CN109157229A - A kind of continuous artery blood glucose monitoring device and its control method - Google Patents
A kind of continuous artery blood glucose monitoring device and its control method Download PDFInfo
- Publication number
- CN109157229A CN109157229A CN201810695494.8A CN201810695494A CN109157229A CN 109157229 A CN109157229 A CN 109157229A CN 201810695494 A CN201810695494 A CN 201810695494A CN 109157229 A CN109157229 A CN 109157229A
- Authority
- CN
- China
- Prior art keywords
- blood
- blood glucose
- glucose meter
- test paper
- syringe
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000004369 blood Anatomy 0.000 title claims abstract description 210
- 239000008280 blood Substances 0.000 title claims abstract description 207
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 title claims abstract description 120
- 239000008103 glucose Substances 0.000 title claims abstract description 120
- 210000001367 artery Anatomy 0.000 title claims abstract description 33
- 238000000034 method Methods 0.000 title claims abstract description 23
- 238000012806 monitoring device Methods 0.000 title claims abstract description 23
- 230000004872 arterial blood pressure Effects 0.000 claims abstract description 27
- 238000012544 monitoring process Methods 0.000 claims abstract description 24
- 239000007788 liquid Substances 0.000 claims abstract description 21
- 150000003839 salts Chemical class 0.000 claims abstract description 18
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 18
- 238000002627 tracheal intubation Methods 0.000 claims abstract description 14
- 239000003146 anticoagulant agent Substances 0.000 claims abstract description 12
- 229940127219 anticoagulant drug Drugs 0.000 claims abstract description 12
- 238000009530 blood pressure measurement Methods 0.000 claims abstract description 10
- 230000000694 effects Effects 0.000 claims abstract description 4
- 238000012360 testing method Methods 0.000 claims description 57
- 239000002775 capsule Substances 0.000 claims description 10
- 230000010354 integration Effects 0.000 claims description 10
- 230000004044 response Effects 0.000 claims description 8
- 239000007924 injection Substances 0.000 claims description 7
- 238000002347 injection Methods 0.000 claims description 7
- 238000004820 blood count Methods 0.000 claims description 6
- 238000010241 blood sampling Methods 0.000 claims description 6
- 241000490229 Eucephalus Species 0.000 claims description 5
- 238000001514 detection method Methods 0.000 claims description 5
- 238000010521 absorption reaction Methods 0.000 claims description 4
- 230000009471 action Effects 0.000 claims description 4
- 239000000284 extract Substances 0.000 claims description 4
- 238000000605 extraction Methods 0.000 claims description 4
- 239000002184 metal Substances 0.000 claims description 4
- 239000002504 physiological saline solution Substances 0.000 claims description 3
- 239000013589 supplement Substances 0.000 claims description 2
- 238000007689 inspection Methods 0.000 abstract description 2
- 230000008569 process Effects 0.000 abstract description 2
- 238000004886 process control Methods 0.000 abstract description 2
- 230000000630 rising effect Effects 0.000 abstract description 2
- 201000001421 hyperglycemia Diseases 0.000 description 7
- 238000004891 communication Methods 0.000 description 5
- 230000008859 change Effects 0.000 description 4
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 4
- 238000005259 measurement Methods 0.000 description 4
- 206010012601 diabetes mellitus Diseases 0.000 description 3
- 238000010586 diagram Methods 0.000 description 3
- 208000013016 Hypoglycemia Diseases 0.000 description 2
- 102000004877 Insulin Human genes 0.000 description 2
- 108090001061 Insulin Proteins 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000001802 infusion Methods 0.000 description 2
- 229940125396 insulin Drugs 0.000 description 2
- 230000010412 perfusion Effects 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 238000007920 subcutaneous administration Methods 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 210000003462 vein Anatomy 0.000 description 2
- 208000030090 Acute Disease Diseases 0.000 description 1
- QCDFBFJGMNKBDO-UHFFFAOYSA-N Clioquinol Chemical compound C1=CN=C2C(O)=C(I)C=C(Cl)C2=C1 QCDFBFJGMNKBDO-UHFFFAOYSA-N 0.000 description 1
- 208000028399 Critical Illness Diseases 0.000 description 1
- 108010015776 Glucose oxidase Proteins 0.000 description 1
- 239000004366 Glucose oxidase Substances 0.000 description 1
- 208000001953 Hypotension Diseases 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 210000001736 capillary Anatomy 0.000 description 1
- 239000000701 coagulant Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 210000003722 extracellular fluid Anatomy 0.000 description 1
- 229940116332 glucose oxidase Drugs 0.000 description 1
- 235000019420 glucose oxidase Nutrition 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 230000002641 glycemic effect Effects 0.000 description 1
- 230000002218 hypoglycaemic effect Effects 0.000 description 1
- 230000002631 hypothermal effect Effects 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- YWXYYJSYQOXTPL-SLPGGIOYSA-N isosorbide mononitrate Chemical compound [O-][N+](=O)O[C@@H]1CO[C@@H]2[C@@H](O)CO[C@@H]21 YWXYYJSYQOXTPL-SLPGGIOYSA-N 0.000 description 1
- 208000012866 low blood pressure Diseases 0.000 description 1
- 230000000116 mitigating effect Effects 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 210000002321 radial artery Anatomy 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 230000001502 supplementing effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 239000002550 vasoactive agent Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/157—Devices characterised by integrated means for measuring characteristics of blood
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
Abstract
The invention discloses a kind of continuous artery blood glucose monitoring device and its control methods, belong to the technical field of medical sanitary apparatus and method, borrow the threeway of original arterial pressure measurement patient monitor, pressure pipe, take blood mouth, the devices such as arterial intubation, the on-off of corresponding intrument is carried out using the several groups conducting wire of the continuous artery blood glucose meter of process control, switch, closure, clamping, the movement such as rotation, so that sequentially realizing the truncation of the anticoagulant salt water of arterial pressure measurement process, program-controlled integral collecting syringe draws the program-controlled rising that the liquid in arterial intubation realizes blood face, electrical clip sub-folder takes small-sized integrated acquisition syringe to realize blood collection and inspection, and various data are recorded by blood glucose meter, storage and analytic function, outwardly transmit and realize simultaneously the functions such as alarm, the workload of medical staff can greatly be mitigated, simultaneously Improve the precision and effect of blood sugar monitoring.Thinking of the present invention is exquisite, modularization is good, it is anti-interference it is strong, at low cost, be easy it is program-controlled realize, function easily extend, blood sugar monitoring precision height.
Description
Technical field
The invention belongs to the technical fields more particularly to a kind of continuous artery blood sugar monitoring of medical sanitary apparatus and method to set
Standby and its control method.
Background technique
Normal blood glucose level is necessary to body maintains physiological function, however under Severe acute disease state, Bing Renyou
, often there is the blood glucose rise of transience, referred to as stress hyperglycemia, stress hyperglycemia in, islet function obstacle critical in the state of an illness
Being defined as blood glucose rise in the case where acute illness is more than 11.1mmol/L.Studies have shown that the incidence of patient's ICU hyperglycemia
Up to 8O%.It may be that ICU complications of patients undergoing incidence and the death rate are raised most that generally acknowledged viewpoint, which is stress hyperglycemia, now
Big risk factor (reference: McDonnell ME, Umpierrez GE. Insulin therapy for the
management of hyperglycemia in hospitalized patients.Endocrinol Metab Clin
North Am. 2012 Mar;41 (1): 175-201.).Therefore, Critical Ill Patient itself Clinical changes (disease severity,
The change of nutritional support, application of cortin etc.) dosage that need to frequently adjust insulin, now clinically still between tip
Based on disconnected monitoring blood glucose, and the blood glucose value for being interrupted some time point of monitoring can not embody true different blood glucose levels, more
It is difficult to find asymptomatic hyperglycemia and hypoglycemia, so glycemic control cannot be instructed well.
In recent years, continuity dynamic blood sugar monitoring system (CGM) came out, and different from conventional method, it is to pass through heeling-in
Subcutaneous glucose oxidase pop one's head in measurement interstitial fluid concentration of glucose to reflect blood glucose level indirectly, can be continuously real
When monitor blood glucose level.Be initially designed for diabetes patient, though have proven to have in diabetic good accurate
Property, but its some aspects is not suitable for Critical Ill Patient, the generally existing tissue edema of Critical Ill Patient, hypothermia, low blood pressure,
The factors such as vasoactive agent application are possible to influence the diffusion of glucose between tissue and blood, and then influence monitoring device
Accuracy.Chinese Dynamic Blood Glucose Monitoring clinical application guide (reference: China of diabetology branch of Chinese Medical Association dynamic glucose
Monitoring clinical application guide version in ' 2012 ' [J] China diabetes magazine, 2012, (10): 582-590.) it points out based on accurate
Property and safety in terms of evidence-based medical limitation, wouldn't recommend to adopt merely in intensive care unit (ICU) or operating room
Blood sugar monitoring is carried out with real-time CGM technology.(the reference: Rijkenberg S, van Steen SC et al. of correlative study data
Accuracy and reliability of a subcutaneous continuous glucose monitoring
device in critically ill patients. J Clin Monit Comput. 2017 Dec 7.doi:
[10.1007/s10877-017-0086-z. Epub ahead of print]) display, urgent patient's randomised controlled trials result
Show that the accuracy of CGM does not reach expected standard requirements.Therefore, CGM is not appropriate for for urgent patient.It is domestic at present
Noninvasive and minimally invasive blood glucose monitoring device is unable to satisfy high-precision and requirement of real-time (reference: Li Hang, infrared Non-invasive detection blood glucose meter
Study [D], University of Electronic Science and Technology's master thesis, Chengdu, 2016.), and do not meet the non-length that patient ICU uses
Phase detection, the continuous monitoring device of high-precision blood glucose.American Media refers within 2018, and apple bioengineer " secret team " is
The sensor made a Noninvasive for Apple Watch, can carry out continuous monitoring to blood glucose level, this method belong to nothing
Wound detection, precision, real-time etc. are largely also all difficult to meet the high real-time of Critical Ill Patient, high-precision spy
It is different to require.
It is artery, vein, capillary that blood sugar monitoring, which samples priority,.For implementing the critical of invasive intravascular monitoring
All blood samples of patient should be derived from artery, cannot obtain arterial blood person, should leave and take venous samples, and capillary blood sample (needle point method) is surveyed
Result inaccuracy is measured, use should be avoided.Hair can be used in the patient that invasive intravascular monitoring relatively need not be gently carried out for the state of an illness
Thin blood vessel blood sample (needle point method).When the ICU Patients of Intensive Care Unit state of an illness is critical, there is arterial pressure monitoring device, be more than oar
Arterial intubation.Therefore using the invasive device of radial artery detaining tube, the monitoring of blood glucose is carried out.
Summary of the invention
The technical problem to be solved by the present invention is to provide a kind of continuous artery blood glucose in view of the defects existing in the prior art
Monitoring device and its control method.
The present invention uses following technical scheme to solve above-mentioned technical problem
A kind of continuous artery blood glucose monitoring device measures patient monitor, conducting wire, motor switch, one comprising blood glucose meter, arterial pressure
Change acquisition syringe, electronic clip, rotary electric bracket, blood sugar test paper;
Wherein, blood glucose meter is acted by polygon control survey motor switch and electronic clip, for realizing integral collecting injection
The specific position and specific action of device;
Blood glucose meter carries out automation blood sugar monitoring by rotary electric bracket, for the circulation access of blood sugar test test paper, telecommunications
Number extraction, blood sugar test paper update;
Blood glucose meter measures patient monitor with arterial pressure by wired or wireless method and connect, and by motor switch, realizes defeated
Conducting and truncation liquid in hydraulic solenoid.
As a kind of further preferred scheme of continuous artery blood glucose monitoring device of the present invention, blood glucose meter can be controlled manually
System and programming, and it controls variable and is embodied by sports apparatus.
As a kind of further preferred scheme of continuous artery blood glucose monitoring device of the present invention, the integral collecting injection
Device includes rubber capsule, holding position cylinder and hollow metal needle, for realizing contact pin, injection, absorption, instillation liquid.
As a kind of further preferred scheme of continuous artery blood glucose monitoring device of the present invention, for realizing integral collecting
The specific position and specific action of syringe are specific as follows: blood glucose meter realizes integral collecting by the electronic clip of polygon control survey
Syringe specific position clamping, draw liquid, discharge liquid and abandon a series of circulate operations of collector.
As a kind of further preferred scheme of continuous artery blood glucose monitoring device of the present invention, for blood sugar test test paper
Circulation access, the extraction of electric signal, the update of blood sugar test paper are specific as follows: blood glucose meter is driven by control rotary electric bracket
The rotation of test paper turntable, to constantly update test paper, while can pass through conducting wire for the detection effect of the blood blood glucose of test paper
Blood glucose meter is passed to show.
A kind of control method based on continuous artery blood glucose monitoring device, it is characterised in that: specifically comprise the following steps:
A: connection arterial pressure measurement patient monitor, continuous artery blood glucose meter and various stationary fixtures, electric fixture, motor switch
Deng;The blood sugar test period is set, and starts timing and starts;
B: reaching time-count cycle, and arterial pressure measures patient monitor work stoppage, and the timing time automatic clear of blood glucose meter starts again
Secondary timing;
C: blood glucose meter controls motor switch movement, and anticoagulant salt water or physiological saline is prevented to flow down;
D: blood glucose meter pilot opens electronic clip, and certain liquid is extracted from pressure pipe, guarantees taking the blood mouth can to obtain
Obtain pure new blood;
E: blood glucose meter controls rotary electric bracket and clamps integral collecting syringe in pickup area, and adopts integration sucking blood area
Collection syringe is pierced into the blood sampling device draw blood for taking blood mouth, and control rotary electric bracket rotates to blood count area, integration is adopted
Collect the blood that syringe is drawn to squeeze out, is added dropwise to the test paper blood glucose response area of test paper turntable, the electric current after blood glucose response passes through examination
The electrode district and conducting wire of paper are transmitted to blood glucose meter and show, record, storing, counting and trend prediction, and as desired by logical
Letter form is sent to user and reminds and alert;
D: blood glucose meter control rotary electric bracket rotates to aster area, abandons integral collecting syringe, meanwhile, it is controlled in blood glucose meter
The control rotary electric bracket that test paper processed updates extracts used test paper before this, and is recycled at new test paper;
E: blood glucose meter passes through the integral collecting syringe of the electronic clip extruding large of polygon control survey, its internal liquid is discharged
To pressure pipe, and opening motor switch is connected upper and lower salt water, and supplements salt water to arterial intubation with certain speed.Blood glucose meter
Break-off, arterial pressure, which measures patient monitor work, to be continued.
F: before the time to blood sugar monitoring time, arterial pressure monitor is worked normally.To the blood sugar monitoring time, then
It is recycled from b step to step e, carries out blood sugar monitoring process.
6. the control method of continuous artery blood glucose monitoring device according to claim 6, it is characterised in that: one
The capacity for changing acquisition syringe is directly proportional to the amount of the required acquisition reached or injecting blood, and can disposably reach,
Amount blood volume as needed for blood sugar test paper of small-sized integral collecting syringe volume and practical draw blood directly determines, greatly
The volume of type integral collecting syringe can be set according to following method:
V=n*L* π * r*r,
Wherein, r is the radius of the inner tube of pressure pipe;π is pi;L is arterial intubation to the distance taken at blood mouth;N is length
Coefficient generally takes 1.5;V is the volume for the liquid that integration acquisition syringe needs to extract inside pressure pipe.
The invention adopts the above technical scheme compared with prior art, has following technical effect that
The method of the invention borrows the threeway of original arterial pressure measurement patient monitor, pressure pipe, takes blood mouth, arterial intubation etc.
Device, using the several groups conducting wire of the continuous artery blood glucose meter of process control carry out the on-off of corresponding intrument, switch, closure, clamping,
The movement such as rotation, so that sequentially realizing that truncation, the program-controlled integration of the anticoagulant salt water of arterial pressure measurement process or physiological saline are adopted
Collection syringe draws the liquid in arterial intubation and realizes that the program-controlled rising of blood face, electrical clip sub-folder take small-sized integrated acquisition to infuse
Emitter realizes blood collection and inspection, record, analysis, storage etc.;
The present invention is not only capable of dynamic monitoring patient blood glucose's value of continuous cycles, and is able to carry out and automatically records, alarms
Etc. various additional functions;Simultaneously, additionally it is possible to greatly alleviate the workload of medical staff, improve medical staff and (especially face
Severe patient situation is such as: emergency treatment or the ward ICU) medical care efficiency and task performance, allow medical staff the field of needs more
It plays a role well;
Thinking of the present invention is exquisite, modularization is good, it is anti-interference it is strong, at low cost, be easy program-controlled realization, have good utilization and extention latent
Power;
The present invention be it is a kind of provide the automation equipment of continuous artery blood glucose measurement for clinical urgent patient, it is dynamic that patient can be monitored
The dynamic change of arteries and veins blood glucose can adjust corresponding parameter according to the needs of the state of an illness within a certain period of time, alarming line is arranged, for doctor
Raw clinical decision provides accurate foundation.Meanwhile the dynamic change figure based on its artery blood glucose realized, it can find in time low
Blood glucose and hyperglycemia, and give intervene in time.Further, it is also possible to which mitigating nurse is repeated as many times measurement blood when patient's state of an illness is critical
Sugar had both reduced the incidence that needle is stabbed, and can also greatly mitigate the workload of medical staff, to guarantee that nurse can rob in time
Other urgent patients are rescued, do not influence the time of measuring requirement of blood glucose, do not influence doctor's decision made to glucose variation.
Detailed description of the invention
Fig. 1 is continuous artery blood glucose meter monitoring method schematic diagram;
Fig. 2 is integral collecting syringe schematic diagram;
Fig. 3 is test paper schematic diagram.
Specific embodiment
Technical solution of the present invention is described in further detail with reference to the accompanying drawing:
As shown in Figure 1, the technical solution of invention is described in detail with reference to the accompanying drawing:
1 in figure, pressure sensor that 2,3 three parts are arterial pressure monitor is to patient monitor display portion: wherein 1 is artery
Pressure measurement patient monitor;2 be pressure sensor interface cable;3 be pressure sensor;
4 in figure, 5,6 three parts be anticoagulant salt water and perfusion tube and valve portion: wherein 4 be valve;5 be minim pipette;6 are
Anticoagulant salt water;
It 7,8,9,10,11 is infusion pressure pipe in figure, infusion tee switch, perfusion tube take blood mouth, arterial intubation part: wherein 7
For threeway a;8 be threeway b;9 be pressure pipe;10 be mouth of sucking blood;11 be arterial intubation;
12,13 be two parts of motor switch on conducting wire a and conducting wire in figure: wherein 12 be motor switch;13 conducting wire a.
14,15,16,17 be conducting wire b and the electronic clip of polygon control survey, integral collecting syringe and fixing clamp in figure
Tool: where 14 be special integral collecting syringe, referred to as integral collecting syringe or integral collecting injection
Device includes the hollow metal needle of a rubber capsule part, the holding position b cylinder, c.[explanation: being the integration of big model at threeway b8
Integral collecting syringe 14 is acquired, the liquid of several milliliters of magnitudes can be extracted];15 be clamping integral collecting syringe rubber
The electronic clip of hide glue capsule;16 be conducting wire b;17 fixation to be clamped to holding position cylinder in the middle part of integral collecting syringe
Fixture;
18,19,20,21,22,23,24,25 be to carry out periodical automation collection and drop takes the rotating device portion of blood in figure
Point: where 18 be the electronic clip [explanation: this place automation collection for clamping integrated integral collecting syringe rubber capsule
Be at blood ting model integral collecting integral collecting syringe 14 it is small, can extract tens arrive a few hectolambda magnitudes liquid
Body];19 be the electronic clip for clamping holding position cylinder in the middle part of integrated integral collecting syringe;20 be to provide electronic clip 18
With 19 conducting wire c;21 be can be that electrical clip 18 and 19 provides the rotary electric bracket a of electronic rotation function;22 be electronic
Clip 18 and electronic clip 19 clamp the pickup area of integrated integral collecting syringe;23 be electronic clip 18 and electronic clip
19 clamp the area of sucking blood that integrated integral collecting syringe extract blood;24 press from both sides for electronic clip 18 and electronic clip 19
Integrated integral collecting syringe is taken to carry out the blood count area that discharge blood carries out blood count;25 be electronic clip 18 and electronic clip
19 abandon or give up the aster area of integrated integral collecting syringe;
In figure 26,27,28,29 for automatic operation blood sugar test paper and its turntable rotary electric bracket, carry out blood sugar test and
The part of display: where 26 be conducting wire d;27 be the test paper turntable of blood sugar test paper, thereon comprising multiple mounted blood glucose examinations
Paper, convenient for the blood sugar test in later period, and blood sugar test paper uniformly passes through 26 conducting wire d and is connected with 29 continuous artery blood glucose meters;28 are
The rotary electric bracket b of 27 test paper turntables of automatic rotation;29 be continuous artery blood glucose meter, and abbreviation blood glucose meter, which can
Pass through interface, 13 conducting wire a of operation, programming and control, 16 conducting wire b, 20 conducting wire c, 26 conducting wire d and 21 rotary electric bracket a, 27
Rotary electric bracket b's acts relative to inductive switch or rotation etc..[explanation, all conducting wires of this paper are characterize data stream
It controls, under actual conditions, wired mode communication control may be implemented, also can according to need with communication control and reality
It is existing]
30 be blood glucose meter test paper, including a blood glucose response area part and b electrode district part in figure.It is wherein more on 27 test paper turntables
The electrode district part of a blood glucose meter test paper is connect by 26 conducting wire d with 29 blood glucose meters, to measure the blood glucose value in blood.
The above-mentioned course of work is as follows:
Step 1: [initial and work]: connecting all equipment and device according to Fig. 1, including arterial pressure measures 1 He of patient monitor
Continuous artery blood glucose meter 29 and various stationary fixtures 17 and electric fixture 15 etc., are in working condition, set blood glucose meter pair
The blood sugar test period of patient be N minutes (such as: 5 minutes) once, blood glucose meter timing starts, and arterial pressure measures patient monitor 1
It works normally.Arterial pressure measures in patient monitor normal work, and anticoagulant salt water is with certain speed injection minim pipette 5 and pressure pipe
9, the pressure in pipe is converted electric signal by pressure sensor 3, is transferred to arterial pressure prison by pressure sensor interface cable 2
Protect real-time display in instrument.
Step 2: [N minutes periods]: after reaching N minutes, blood glucose meter notifies artery by wired or wireless communication link
Pressure measurement patient monitor work stoppage, the timing time automatic clear of blood glucose meter, and the timing again since 0.
Step 3: [shutting off] blood glucose meter 29 controls motor switch 12 by pilot a13.Motor switch 12 is controlled to close
Threeway a7 prevents anticoagulant salt water from flowing down.At this point, the arterial pressure data of the pressure sensor 3 of measurement blood pressure remain unchanged.
Step 4: 29 pilot b16 of [reflux] blood glucose meter, the electronic clip 15 initially closed is opened, by large size
Number integral collecting syringe 14 rubber capsule elastic force, certain liquid is extracted from pressure pipe.It needs to illustrate
It is that the operation must guarantee that the blood liquid level in arterial intubation rises, and the interface of blood and anticoagulant salt water should be located at
It takes between blood mouth 10 and threeway b8, guarantees that pure new blood can be obtained when taking the blood sampling device of blood mouth 10 to take blood.
Step 5: [pickup]: blood glucose meter 29 controls rotary electric bracket a21, goes at pickup area 22, orderly stores at this
The integral collecting syringe 14 of many ting models is small, i.e., integral collecting syringe 14 is small.Blood glucose meter passes through conducting wire c20
It controls electronic clip 18 and the clamping integral collecting syringe 14 of electronic clip 19 is small.Electronic clip 19 clamps the one of pickup area 22
Bodyization acquires the small holding position cylinder b of syringe 14.Electronic clip 18 clamps the small upper end of integral collecting syringe 14 simultaneously
Rubber capsule a allows it to exclude internal gas, for preparing for subsequent absorption blood.
Step 6: [sucking blood]: blood glucose meter 29 controls rotary electric bracket a21, rotates to suck blood and area 23 and stops operating.And
Electronic clip 19 and electronic clip 18 are controlled by conducting wire c20.Electronic clip 19 and electronic clip 18 are in clamping integral collecting
The blood sampling device rubber cap taken at blood mouth 10, blood and pressure below blood sampling device rubber cap are pierced into while syringe 14
The blood of pipe communicates.After piercing, electronic clip 18 unclamps, and is inhaled by the elastic force of the small rubber capsule of integral collecting syringe 14
Take blood;After draw blood, electronic clip 19 is pulled out from the blood sampling device rubber cap in area of sucking blood by integral collecting syringe 14 is small
Out.
Step 7: [blood count]: blood glucose meter 29 controls rotary electric bracket a21, rotates to blood count area 24 and stops operating.Blood
Sugared instrument 29 controls rotary electric bracket b28, by rotation or circulator (this place is rotation test paper turntable 27), by test paper 30
Blood glucose response area a is gone to below the small hollow metal needle of integral collecting syringe 14, waits blood.Blood glucose meter 29 passes through conducting wire
C20 control electronic clip 18 clamp integral collecting syringe 14 it is small on rubber capsule, integral collecting syringe 14 is small
The blood of middle absorption squeezes out, and can just be added dropwise to the 30 blood glucose response area a of test paper being distributed on test paper turntable 27, after blood glucose response
Electric current by the electrode district and conducting wire d26 of test paper 30 be transmitted to blood glucose meter 29 display, record, storage, statistics and trend it is pre-
It surveys, and the intelligent communication self-contained by blood glucose meter, is sent to user and reminds and alert].
Step 8: [aster]: blood glucose meter 29 controls rotary electric bracket a21, rotates to aster area 25, and pass through conducting wire
C20 controls electronic clip 18 and electronic clip 19 unclamps, and it is small to abandon integral collecting syringe 14, and stop operating, wait into
Enter next cycle period.Blood glucose meter 29 controls rotary electric bracket b28, used test paper 30 before this is extracted, so that the test paper
Electrode district be detached from conducting wire d (26), wait enter next cycle period.If [test paper of test paper turntable is all extracted, then is needed
It is loaded test paper, is disposably loaded test paper turntable complete]
Step 9: [sending stream]: blood glucose meter 29 controls electronic clip 15 by conducting wire b16, squeezes integral collecting syringe 14
Rubber capsule, so that its internal liquid is discharged into pressure pipe 9, so that anticoagulant salt water and blood are passed through arterial intubation 11
Blood is returned to, while anticoagulant salt water is washed away and taken at blood mouth 10.Blood glucose meter 29 opens motor switch 12 by conducting wire a13, makes threeway
The salt water up and down of a7 is connected, and continues anticoagulant salt water 6 supplementing salt water to arterial intubation 11 with certain speed.At the same time,
Blood glucose meter notifies arterial pressure to measure patient monitor work and continue by wired or wireless communication link, and pressure sensor 3 continues
It works normally, and passes the signal in arterial pressure measurement patient monitor 1 and show.
Step 10: [measuring again]: not arriving N minutes, then continue the arterial pressure monitor course of work.If arriving N minutes, turn
To second step, the course of work circulation of blood glucose meter 29 is carried out from second step to step 9.
Claims (7)
1. a kind of continuous artery blood glucose monitoring device, it is characterised in that: comprising blood glucose meter, arterial pressure measurement patient monitor, conducting wire,
Motor switch, integral collecting syringe, electronic clip, rotary electric bracket, blood sugar test paper;
Wherein, blood glucose meter is acted by polygon control survey motor switch and electronic clip, for realizing integral collecting injection
The specific position and specific action of device;
Blood glucose meter carries out automation blood sugar monitoring by rotary electric bracket, for the circulation access of blood sugar test test paper, telecommunications
Number extraction, blood sugar test paper update;
Blood glucose meter measures patient monitor with arterial pressure by wired or wireless method and connect, and by motor switch, realizes defeated
Conducting and truncation liquid in hydraulic solenoid.
2. a kind of continuous artery blood glucose monitoring device according to claim 1, it is characterised in that: blood glucose meter can carry out manually
Control and programming, and it controls variable and is embodied by sports apparatus.
3. a kind of continuous artery blood glucose monitoring device according to claim 1, it is characterised in that: the integral collecting note
Emitter includes rubber capsule, holding position cylinder and hollow metal needle, for realizing contact pin, injection, absorption, instillation liquid.
4. a kind of continuous artery blood glucose monitoring device according to claim 1, it is characterised in that: adopted for realizing integration
Specific position and the specific action for collecting syringe are specific as follows: blood glucose meter realizes that integration is adopted by the electronic clip of polygon control survey
Collection syringe specific position clamping, draw liquid, discharge liquid and abandon a series of circulate operations of collector.
5. a kind of continuous artery blood glucose monitoring device according to claim 1, it is characterised in that: be used for blood sugar test test paper
Circulation access, the extraction of electric signal, the update of blood sugar test paper it is specific as follows: blood glucose meter passes through control rotary electric bracket, band
Dynamic test paper turntable rotation, to constantly update test paper, while can be by the detection effect of the blood blood glucose of test paper, by leading
Line passes to blood glucose meter and shows.
6. a kind of control method based on the continuous artery blood glucose monitoring device described in claim 1 to 5, it is characterised in that: tool
Body includes the following steps:
A: connection arterial pressure measurement patient monitor, continuous artery blood glucose meter and various stationary fixtures, electric fixture, motor switch
Deng;The blood sugar test period is set, and starts timing and starts;
B: reaching time-count cycle, and arterial pressure measures patient monitor work stoppage, and the timing time automatic clear of blood glucose meter starts again
Secondary timing;
C: blood glucose meter controls motor switch movement, and anticoagulant salt water or physiological saline is prevented to flow down;
D: blood glucose meter pilot opens electronic clip, and certain liquid is extracted from pressure pipe, guarantees taking the blood mouth can to obtain
Obtain pure new blood;
E: blood glucose meter controls rotary electric bracket and clamps integral collecting syringe in pickup area, and adopts integration sucking blood area
Collection syringe is pierced into the blood sampling device draw blood for taking blood mouth, and control rotary electric bracket rotates to blood count area, integration is adopted
Collect the blood that syringe is drawn to squeeze out, is added dropwise to the test paper blood glucose response area of test paper turntable, the electric current after blood glucose response passes through examination
The electrode district and conducting wire of paper are transmitted to blood glucose meter and show, record, storing, counting and trend prediction, and as desired by logical
Letter form is sent to user and reminds and alert;
D: blood glucose meter control rotary electric bracket rotates to aster area, abandons integral collecting syringe, meanwhile, it is controlled in blood glucose meter
The control rotary electric bracket that test paper processed updates extracts used test paper before this, and is recycled at new test paper;
E: blood glucose meter passes through the integral collecting syringe of the electronic clip extruding large of polygon control survey, its internal liquid is discharged
To pressure pipe, and opening motor switch is connected upper and lower salt water, and supplements salt water to arterial intubation with certain speed;
Blood glucose meter break-off, arterial pressure, which measures patient monitor work, to be continued;
F: before the time to blood sugar monitoring time, arterial pressure monitor is worked normally;
It to the blood sugar monitoring time, is then recycled from b step to step e, carries out blood sugar monitoring process.
7. the control method of continuous artery blood glucose monitoring device according to claim 6, it is characterised in that: integral collecting
The capacity of syringe is directly proportional to the amount of the required acquisition reached or injecting blood, and can disposably reach, small-sized
Integral collecting syringe volume and amount blood volume as needed for blood sugar test paper of practical draw blood directly determine, large-scale one
The volume for changing acquisition syringe can be set according to following method:
V=n*L* π * r*r,
Wherein, r is the radius of the inner tube of pressure pipe;π is pi;L is arterial intubation to the distance taken at blood mouth;N is length
Coefficient generally takes 1.5;V is the volume for the liquid that integration acquisition syringe needs to extract inside pressure pipe.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201810695494.8A CN109157229B (en) | 2018-06-29 | 2018-06-29 | Continuous arterial blood glucose monitoring equipment and control method thereof |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201810695494.8A CN109157229B (en) | 2018-06-29 | 2018-06-29 | Continuous arterial blood glucose monitoring equipment and control method thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
CN109157229A true CN109157229A (en) | 2019-01-08 |
CN109157229B CN109157229B (en) | 2024-03-29 |
Family
ID=64897434
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201810695494.8A Active CN109157229B (en) | 2018-06-29 | 2018-06-29 | Continuous arterial blood glucose monitoring equipment and control method thereof |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN109157229B (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112494023A (en) * | 2019-09-16 | 2021-03-16 | 深圳市惠心诺科技有限公司 | Closed invasive blood pressure monitoring equipment with blood sampling function |
CN113116348A (en) * | 2021-03-02 | 2021-07-16 | 天津大学 | Continuous arterial blood detection device |
Citations (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1991012036A1 (en) * | 1990-02-06 | 1991-08-22 | Friedhelm Beyersdorf | Reperfusion device |
EP0461207A1 (en) * | 1989-08-11 | 1991-12-18 | Palti Yoram Prof | System for monitoring and controlling blood glucose. |
JPH07213604A (en) * | 1994-02-04 | 1995-08-15 | Yoshihiko Suzuki | Controller of blood sugar value |
US5687718A (en) * | 1994-07-09 | 1997-11-18 | Hewlett-Packard Company | Device for continuously detecting blood parameters |
US5971941A (en) * | 1997-12-04 | 1999-10-26 | Hewlett-Packard Company | Integrated system and method for sampling blood and analysis |
EP1048310A2 (en) * | 1999-04-26 | 2000-11-02 | Becton Dickinson and Company | Integrated system including medication delivery pen, blood monitoring device, and lancer |
US20030055323A1 (en) * | 2001-09-19 | 2003-03-20 | Choi Soo Bong | Portable automatic insulin syringe device with blood sugar measuring function |
WO2003051427A1 (en) * | 2001-12-18 | 2003-06-26 | Jms Co.,Ltd. | Automatic apparatus for blood dialyis and priming method using the apparatus |
WO2007002209A2 (en) * | 2005-06-20 | 2007-01-04 | Glucon, Inc. | Blood parameter testing system |
US20070015285A1 (en) * | 1999-04-02 | 2007-01-18 | Inverness Medical Switzerland Gmbh/Unipath | Test methods, devices and test kits |
US20070179435A1 (en) * | 2005-12-21 | 2007-08-02 | Braig James R | Analyte detection system with periodic sample draw and body fluid analyzer |
WO2007149980A2 (en) * | 2006-06-21 | 2007-12-27 | C K Dalebout Enterprise Llc | Systems, methods, and devices for sampling bodily fluid |
US20090099507A1 (en) * | 2005-10-26 | 2009-04-16 | Variak | Device for Automatic Regulation of the Concentration of Glucose in the Blood of a Diabetes Patient |
US20100094113A1 (en) * | 2008-10-09 | 2010-04-15 | Mark Ries Robinson | Hemodynamic monitoring during automated measurement of blood constituents |
US20100137778A1 (en) * | 2008-12-02 | 2010-06-03 | Kislaya Kunjan | Automated Blood Sampler and Analyzer |
US20100168535A1 (en) * | 2006-04-12 | 2010-07-01 | Mark Ries Robinson | Methods and apparatuses related to blood analyte measurement system |
KR20110128548A (en) * | 2010-05-24 | 2011-11-30 | 대전보건대학 산학협력단 | One coding blood glucose tester and blood glucose management system using the same |
CN102406972A (en) * | 2011-09-26 | 2012-04-11 | 肖俊涛 | Medical quantitative infusion device |
CN102762148A (en) * | 2010-02-16 | 2012-10-31 | 崔仁相 | Blood glucose measuring system, strip receiving apparatus, strip storage apparatus and automatic blood collecting apparatus |
WO2013092969A2 (en) * | 2011-12-22 | 2013-06-27 | Universite Joseph Fourier - Grenoble 1 | Method and device for monitoring blood pressure measurement by arterial catheterization of a patient |
CN103519830A (en) * | 2013-07-29 | 2014-01-22 | 吴洪磊 | Blood collection device used during invasive artery monitoring |
WO2014088581A1 (en) * | 2012-12-06 | 2014-06-12 | Bd Technologies | Multifunctional glucose monitoring system and method of using the same |
WO2015069872A2 (en) * | 2013-11-08 | 2015-05-14 | The Board Of Trustees Of The University Of Illinois | Personal glucose meters for detection and quantification of enzymes and metabolites based on coenzyme detection |
CN107049431A (en) * | 2016-12-30 | 2017-08-18 | 西安中科微光影像技术有限公司 | A kind of automatic puncturing robot |
CN107616799A (en) * | 2016-07-14 | 2018-01-23 | 陈治宇 | A kind of blood glucose on-line real time monitoring system |
-
2018
- 2018-06-29 CN CN201810695494.8A patent/CN109157229B/en active Active
Patent Citations (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0461207A1 (en) * | 1989-08-11 | 1991-12-18 | Palti Yoram Prof | System for monitoring and controlling blood glucose. |
WO1991012036A1 (en) * | 1990-02-06 | 1991-08-22 | Friedhelm Beyersdorf | Reperfusion device |
JPH07213604A (en) * | 1994-02-04 | 1995-08-15 | Yoshihiko Suzuki | Controller of blood sugar value |
US5687718A (en) * | 1994-07-09 | 1997-11-18 | Hewlett-Packard Company | Device for continuously detecting blood parameters |
US5971941A (en) * | 1997-12-04 | 1999-10-26 | Hewlett-Packard Company | Integrated system and method for sampling blood and analysis |
US20070015285A1 (en) * | 1999-04-02 | 2007-01-18 | Inverness Medical Switzerland Gmbh/Unipath | Test methods, devices and test kits |
EP1048310A2 (en) * | 1999-04-26 | 2000-11-02 | Becton Dickinson and Company | Integrated system including medication delivery pen, blood monitoring device, and lancer |
US20030055323A1 (en) * | 2001-09-19 | 2003-03-20 | Choi Soo Bong | Portable automatic insulin syringe device with blood sugar measuring function |
WO2003051427A1 (en) * | 2001-12-18 | 2003-06-26 | Jms Co.,Ltd. | Automatic apparatus for blood dialyis and priming method using the apparatus |
WO2007002209A2 (en) * | 2005-06-20 | 2007-01-04 | Glucon, Inc. | Blood parameter testing system |
US20090099507A1 (en) * | 2005-10-26 | 2009-04-16 | Variak | Device for Automatic Regulation of the Concentration of Glucose in the Blood of a Diabetes Patient |
US20070179435A1 (en) * | 2005-12-21 | 2007-08-02 | Braig James R | Analyte detection system with periodic sample draw and body fluid analyzer |
US20100168535A1 (en) * | 2006-04-12 | 2010-07-01 | Mark Ries Robinson | Methods and apparatuses related to blood analyte measurement system |
WO2007149980A2 (en) * | 2006-06-21 | 2007-12-27 | C K Dalebout Enterprise Llc | Systems, methods, and devices for sampling bodily fluid |
US20100094113A1 (en) * | 2008-10-09 | 2010-04-15 | Mark Ries Robinson | Hemodynamic monitoring during automated measurement of blood constituents |
US20100137778A1 (en) * | 2008-12-02 | 2010-06-03 | Kislaya Kunjan | Automated Blood Sampler and Analyzer |
CN102762148A (en) * | 2010-02-16 | 2012-10-31 | 崔仁相 | Blood glucose measuring system, strip receiving apparatus, strip storage apparatus and automatic blood collecting apparatus |
KR20110128548A (en) * | 2010-05-24 | 2011-11-30 | 대전보건대학 산학협력단 | One coding blood glucose tester and blood glucose management system using the same |
CN102406972A (en) * | 2011-09-26 | 2012-04-11 | 肖俊涛 | Medical quantitative infusion device |
WO2013092969A2 (en) * | 2011-12-22 | 2013-06-27 | Universite Joseph Fourier - Grenoble 1 | Method and device for monitoring blood pressure measurement by arterial catheterization of a patient |
WO2014088581A1 (en) * | 2012-12-06 | 2014-06-12 | Bd Technologies | Multifunctional glucose monitoring system and method of using the same |
CN103519830A (en) * | 2013-07-29 | 2014-01-22 | 吴洪磊 | Blood collection device used during invasive artery monitoring |
WO2015069872A2 (en) * | 2013-11-08 | 2015-05-14 | The Board Of Trustees Of The University Of Illinois | Personal glucose meters for detection and quantification of enzymes and metabolites based on coenzyme detection |
CN107616799A (en) * | 2016-07-14 | 2018-01-23 | 陈治宇 | A kind of blood glucose on-line real time monitoring system |
CN107049431A (en) * | 2016-12-30 | 2017-08-18 | 西安中科微光影像技术有限公司 | A kind of automatic puncturing robot |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112494023A (en) * | 2019-09-16 | 2021-03-16 | 深圳市惠心诺科技有限公司 | Closed invasive blood pressure monitoring equipment with blood sampling function |
CN113116348A (en) * | 2021-03-02 | 2021-07-16 | 天津大学 | Continuous arterial blood detection device |
Also Published As
Publication number | Publication date |
---|---|
CN109157229B (en) | 2024-03-29 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US4573968A (en) | Infusion and blood chemistry monitoring system | |
US7162290B1 (en) | Method and apparatus for blood glucose testing from a reversible infusion line | |
CN102138800B (en) | Piston type portable detection system for blood of human body | |
CN109157229A (en) | A kind of continuous artery blood glucose monitoring device and its control method | |
CN102894981B (en) | Continuous high-precision detecting instrument for blood glucose concentration of human body based on trace blood sampling | |
CN212282416U (en) | Automatic pulse type injection device for injection of arterial intervention chemotherapy drugs | |
CN112138247A (en) | Gate-controlled radiography injection device and injection method | |
CN102160777B (en) | Body fluid bioinformation fiber dynamic testing system | |
CN113144332B (en) | Intelligent injection device and method for monitoring blood sugar and insulin concentration on line | |
CN205549084U (en) | Split type blood drainage ware of drawing blood of multichannel | |
CN209153645U (en) | A kind of continuous artery blood glucose monitoring device | |
CN112494023A (en) | Closed invasive blood pressure monitoring equipment with blood sampling function | |
CN217611041U (en) | Invasive blood pressure sensor with blood storage bypass | |
CN212879318U (en) | Artery blood gas fixed acquisition device under artery pulsation guide | |
CN211292935U (en) | Blood sugar continuous monitoring system | |
CN205144575U (en) | Radial artery blood sampling device | |
CN220025051U (en) | Arterial blood sugar monitoring device | |
CN204708861U (en) | A kind of safety arteriovenous blood-taking device | |
CN209529144U (en) | Venous blood sample collection needle and blood sampling group set | |
CN106963398B (en) | Intelligent vacuum blood sampling assembly | |
CN211155837U (en) | Remaining needle with blood sampling function | |
CN112642018B (en) | Blood sugar detection device matched with venous indwelling needle and detection method thereof | |
CN206729894U (en) | A kind of artery aids in blood-taking device | |
CN204500724U (en) | A kind of can the remaining needle of Real-time Collection blood or administration | |
CN204971211U (en) | A monitoring devices that is used for hemodialysis treatment in -process internal fistula to bleed |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
GR01 | Patent grant | ||
GR01 | Patent grant |