CN109091631A - The Radix Angelicae Sinensis Astragalus in Treating reagent and preparation method for treating early diabetic nephropathy - Google Patents

Abstract

The invention belongs to the technical field of traditional Chinese medicine preparation, and discloses an angelica and astragalus therapeutic reagent for treating early diabetic nephropathy and a preparation method; 10-15 parts of angelica, 8-11 parts of astragalus, 5-8 parts of poria cocos, 3-5 parts of ginseng and 3 parts of codonopsis pilosula ～6 parts, 7～10 parts of Atractylodes macrocephala, 2～4 parts of corn silk, 6～10 parts of tangerine peel, 10～12 parts of Cimicifuga, 10～13 parts of Bupleurum, 8～10 parts of licorice, 15～20 parts of japonica rice, 12-15 parts of female, 4-8 parts of Ophiopogon japonicus, 11-15 parts of kudzu root, 10-15 parts of rehmannia glutinosa, 9-13 parts of Achyranthes bidentata, 10-15 parts of plantain and 6-10 parts of Chuanxiong. The present invention can replenish blood and activate blood, eliminate troubles and soothe the nerves, protect the kidney, reduce nephron damage, increase renal blood flow, improve creatinine clearance rate, reduce monthly urea nitrogen, and protect the kidney against acute renal failure; it can lower blood sugar and reduce proteinuria ; And reduce the nephrotoxic damage caused by gentamicin.

Description

Angelica Astragalus Therapeutic Reagent and Preparation Method for Treating Early Diabetic Nephropathy

technical field

The invention belongs to the technical field of preparation of traditional Chinese medicines, and in particular relates to an angelica astragali therapeutic reagent for treating early diabetic nephropathy and a preparation method thereof.

Background technique

At present, the existing technology commonly used in the industry is as follows: diabetic nephropathy is one of the most important complications of diabetic patients; if diabetic patients develop diabetic nephropathy in the early stage, symptoms such as proteinuria, edema, high blood pressure, renal insufficiency, and anemia will appear The incidence of diabetic nephropathy in China is also on the rise, and it has become the second cause of end-stage renal disease, second only to various glomerulonephritis; due to its complex metabolic disorders, once it develops into end-stage renal disease , is often more difficult to treat than other kidney diseases, so timely prevention and treatment is of great significance for delaying diabetic nephropathy; the existing antihypertensive treatment, antihypertensive drugs can not be stopped at will, and even more serious phenomenon will appear after stopping the drug, Long-term use of antihypertensive drugs will cause side effects such as general weakness, low muscle tone, abdominal distension, loss of appetite, indigestion, and palpitations; new anti-oxidation treatments require cooperation from all aspects of the body, and the medical expenses are high; existing treatments such as injections Insulin, although diet control can control the development of the disease, it cannot effectively regulate the disease and the body, and there are still hidden dangers of disease development in the long run.

In summary, the problems in the prior art are:

(1) The incidence of diabetes in my country is also on the rise, and it has become the second cause of end-stage renal disease, second only to various glomerulonephritis; due to its complex metabolic disorders, once it develops to the end stage, it will Kidney failure is often more difficult to treat than other kidney diseases, so timely prevention and treatment is of great significance for delaying diabetic nephropathy.

(2) In the existing antihypertensive treatment, antihypertensive drugs cannot be stopped at will, and even more serious symptoms may occur after drug withdrawal. Long-term use of antihypertensive drugs will cause general weakness, low muscle tone, abdominal distension, loss of appetite, Indigestion, heart palpitations and other side effects.

(3) The new anti-oxidation treatment method requires the cooperation of all aspects of the whole body, and the medical expenses are high.

(4) Existing treatment methods such as insulin injection and diet control can control the development of the disease, but they cannot effectively regulate the disease and the body, and there are still hidden dangers of disease development in the long run.

Contents of the invention

Aiming at the problems existing in the prior art, the invention provides an angelica astragalus therapeutic agent for treating early diabetic nephropathy.

The present invention is achieved in this way, the Angelica Astragali therapeutic reagent for treating early diabetic nephropathy consists of 10-15 parts of Angelica, 8-11 parts of Astragalus, 5-8 parts of Poria, 3-5 parts of Ginseng, and 3-6 parts of Codonopsis Codonopsis , 7-10 parts of Atractylodes macrocephala, 2-4 parts of corn silk, 6-10 parts of tangerine peel, 10-12 parts of Cimicifuga, 10-13 parts of Bupleurum, 8-10 parts of licorice, 15-20 parts of japonica rice, 12-12 parts of Anemarrhena 15 parts, 4-8 parts of Ophiopogon japonicus, 11-15 parts of kudzu root, 10-15 parts of Rehmannia glutinosa, 9-13 parts of Achyranthes bidentata, 10-15 parts of plantain, 6-10 parts of Chuanxiong, 8-10 parts of salvia miltiorrhiza and Immortal Grass consists of 7 to 10 parts.

Another object of the present invention is to provide a preparation method of Angelica Astragali therapeutic reagent for the treatment of early diabetic nephropathy comprising the following steps:

Step 1: Preparation of medicine: mix the raw materials according to the weight ratio of the formula, remove impurities from the raw materials, wash them, and place them in a cool and dry place to dry naturally;

Step 2: Frying: Preheat the medicinal frying casserole to 80°C-85°C, put each component in the raw material one by one, fry separately, stir fry with a slow fire until it turns brown, then cool to room temperature, and put each The fried components are stirred and mixed to obtain the mixed fried components;

Step 3: Pulverization: Put the mixed and fried components into a pulverization device for pulverization, pass the pulverized components through a 100-120 mesh sieve, and after 3 times of sieving, take the fine material under the sieve;

Step 4: Sterilization: Place the sieved fine material in a radiation source of 60Co-γ, the radiation intensity is 15kGy, and the radiation dose rate is 3.6kGy/h, and ionizing radiation is carried out to kill bacteria;

Step 5: Subpackage: subpackage the sterilized fine material under sieve into capsules according to a certain weight to obtain the reagent.

Further, the pulverization adopts low-temperature pulverization.

Further, the mass of the fine material in the capsule is 0.25 grams.

Further, the mathematical model of the motor used in the pulverization is:

T _e =μJ(λ _dr i _qs -λ _qr i _ds );

in, is the number of pole pairs, d and q are the static coordinate system, and the mathematical model of the motor on the M and T coordinate system is:

Among them, e represents the parameters on the synchronous speed coordinate system.

Further, the voltage equation of the motor is:

Among them, U _ua , U _va , U _wa are the phase voltages of the three-phase windings, R _a is the resistance of each phase winding; I _ua , I _va , I _wa are the phase currents of the three-phase windings, and ψ _ua , ψ _va , ψ _wa are the three Phase armature winding flux linkage, p=d/dt is a differential operator;

The stator voltage equation of the motor is:

The operating potentials e _A , e _B , and e _C are:

ψ _fu , ψ _fv , ψ _fw are the permanent magnet flux linkages of each pole of the three-phase winding rotor, ψ _fa is the permanent magnet flux, L′ _a is the inductance of the armature winding, and M′ _a is the mutual inductance between the armature windings.

In summary, the advantages and positive effects of the present invention are:

Angelica sinensis, Salvia miltiorrhiza, and Rhizoma chuanxiong in the present invention can nourish blood and activate blood, relieve troubles and calm the nerves, protect the kidneys, reduce nephron damage, increase renal blood flow, improve creatinine clearance, reduce monthly urea nitrogen, and have obvious effects on acute renal failure. Kidney protection; Astragalus, Poria, Ginseng, Codonopsis Atractylodes, Atractylodes macrocephala, Japonica rice, Pueraria root, and Achyranthes bidentata can invigorate qi and invigorate the spleen, protect the kidneys, and can lower blood sugar and proteinuria when used together; corn silk, anemarrhena, plantain It has a diuretic effect, and can reduce the nephrotoxic damage caused by gentamicin, and can reduce urine sugar; the herbs of fairy grass, tangerine peel, cohosh, and licorice can clear away heat and detoxify, soothe the liver and raise yang, and effectively prevent the occurrence of kidney failure.

The present invention can replenish blood and activate blood, eliminate troubles and soothe the nerves, protect the kidney, reduce nephron damage, increase renal blood flow, improve creatinine clearance rate, reduce monthly urea nitrogen, and protect the kidney against acute renal failure; it can lower blood sugar and reduce proteinuria ; and can reduce the nephrotoxicity damage caused by gentamicin, and can reduce urine sugar; the medicines of fairy grass, tangerine peel, cohosh, and licorice can clear away heat and detoxify, soothe the liver and raise yang, effectively prevent the occurrence of renal failure, and have no effect on the use of patients any side effects.

In the preparation process, a low-temperature crushing method is adopted to change the ductile crushing of the traditional Chinese medicine into brittle crushing, so as to reduce the deformation of the particles before crushing, ensure sufficient crushing space and reduce energy consumption.

Description of drawings

Fig. 1 is a flow chart of the preparation of the Angelica Astragali therapeutic reagent for treating early diabetic nephropathy provided by the embodiment of the present invention.

Detailed ways

In order to further understand the content, features and effects of the present invention, the following examples are given, and detailed descriptions are given below with reference to the accompanying drawings.

The structure of the present invention will be described in detail below in conjunction with the accompanying drawings.

The Angelica Astragalus treatment reagent for treating early diabetic nephropathy provided by the embodiments of the present invention consists of 10-15 parts of Angelica sinensis, 8-11 parts of Astragalus membranaceus, 5-8 parts of Poria cocos, 3-5 parts of ginseng, 3-6 parts of Codonopsis pilosula, 7-10 parts of Atractylodes macrocephala, 2-4 parts of corn silk, 6-10 parts of tangerine peel, 10-12 parts of Cimicifuga, 10-13 parts of Bupleurum, 8-10 parts of licorice, 15-20 parts of japonica rice, 12-15 parts of Anemarrhena 4-8 parts of Radix Ophiopogon japonicus, 11-15 parts of Pueraria Radix, 10-15 parts of Rehmannia glutinosa, 9-13 parts of Achyranthes bidentata, 10-15 parts of Plantain, 6-10 parts of Chuanxiong, 8-10 parts of Salvia miltiorrhiza and Shenxian Grass consists of 7-10 parts.

As shown in Figure 1, the preparation method of the Chinese medicine compound reagent for the prevention and treatment of gout provided by the embodiment of the present invention comprises the following steps:

S101: Prepare the medicine: mix the raw materials according to the weight ratio of the formula, remove impurities from the raw materials, wash them, and place them in a cool and dry place to dry naturally;

S102: Frying: Preheat the medicinal frying casserole to 80°C-85°C, put each component in the raw material one by one, fry separately, stir fry with a slow fire until it turns brown, cool to room temperature, and fry each component The components are stirred and mixed to obtain the mixed and fried components;

S103: Pulverization: put the mixed and fried components into a pulverization device for pulverization, pass the pulverized components through a 100-120 mesh sieve, and take the fine material under the sieve after 3 times of sieving;

S104: Sterilization: place the sieved fine material in a 60Co-γ radiation source with a radiation intensity of 15kGy and a radiation dose rate of 3.6kGy/h, and perform ionizing radiation to kill bacteria;

S105: Subpackage: subpackage the sterilized fine material under sieve into capsules according to a certain weight, so as to obtain the reagent.

Further, the pulverization adopts low-temperature pulverization.

Further, the mass of the fine material in the capsule is 0.25 grams.

Further, the mathematical model of the motor used in the pulverization is:

T _e =μJ(λ _dr i _qs -λ _qr i _ds );

in, is the number of pole pairs, d and q are the static coordinate system, and the mathematical model of the motor on the M and T coordinate system is:

Among them, e represents the parameters on the synchronous speed coordinate system.

Further, the voltage equation of the motor is:

Among them, U _ua , U _va , U _wa are the phase voltages of the three-phase windings, R _a is the resistance of each phase winding; I _ua , I _va , I _wa are the phase currents of the three-phase windings, and ψ _ua , ψ _va , ψ _wa are the three Phase armature winding flux linkage, p=d/dt is a differential operator;

The stator voltage equation of the motor is:

The operating potentials e _A , e _B , and e _C are:

ψ _fu , ψ _fv , ψ _fw are the permanent magnet flux linkages of each pole of the three-phase winding rotor, ψ _fa is the permanent magnet flux, L′ _a is the inductance of the armature winding, and M′ _a is the mutual inductance between the armature windings.

The pharmacological action of the present invention will be further described below in conjunction with specific examples.

Angelica: Its root can be used as medicine, which has the effects of nourishing blood and promoting blood circulation, regulating menstruation and relieving pain, moistening dryness and smoothing intestines, anti-cancer, anti-aging and anti-aging, and immunity.

Astragalus: This product is the root of the leguminous plant Astragalus mongolica. Its functions and indications are: tonifying qi and solidifying the surface, detoxifying and expelling pus, diuresis, and promoting muscle growth; used for qi deficiency and fatigue, chronic diarrhea and prolapse of the anus, spontaneous sweating, edema, and prolapse of the genitals , chronic nephritis proteinuria, diabetes, sores that do not heal for a long time.

Poria cocos: inducing diuresis and expelling dampness, invigorating the spleen, calming the mind, used for edema, oliguria, dizziness and palpitation due to phlegm retention, deficiency of the spleen, lack of food, loose stool, restlessness, palpitation and insomnia.

Ginseng: The fleshy root of ginseng is a famous strong tonic. It is suitable for adjusting blood pressure, restoring heart function, neurasthenia and physical weakness.

Codonopsis: It has the effects of invigorating the middle and Qi, invigorating the spleen and lungs. Codonopsis has the functions of enhancing immunity, dilating blood vessels, lowering blood pressure, improving microcirculation, and enhancing hematopoietic function.

Atractylodes: Atractylodes have the effects of strengthening the spleen and nourishing qi, dampness and water, antiperspiration, and tires. It is used for spleen deficiency and food, abdominal distension and diarrhea, sputum dizziness, edema, and self -sweating.

Corn silk: the style and stigma of corn, a grass plant, has the effect of diuretic and swelling, clearing liver and gallbladder.

Tangerine peel: it is the dry ripe fruit peel of Rutaceae plant Tangerine and its cultivars, which is used for distension and fullness in the abdomen, lack of appetite, vomiting and diarrhea, and cough with excessive phlegm.

Cimicifuga: The dry rhizome of Cimicifuga clover, Xing'an Cimicifuga or Cimicifuga sativa of Ranunculaceae. The main effect is to release rash, clear away heat and detoxify, raise sun and lift depression.

Bupleurum: It has the effect of reconciling the exterior and interior, soothing the liver and promoting yang; it is used for cold and fever, alternating cold and heat, malaria, liver depression and stagnation of qi, sternal rib pain, anal prolapse, uterine prolapse, and irregular menstruation.

Licorice root: Slight gas, sweet and special taste, functions mainly for clearing away heat and detoxification, eliminating phlegm and relieving cough, abdominal distension, etc.

Japonica rice: It has the effects of nourishing yin and promoting body fluid, relieving restlessness and quenching thirst, invigorating the spleen and stomach, invigorating the middle Qi, strengthening the intestines and relieving diarrhea.

Anemarrhena: Functions and indications, nourishing yin and reducing fire, moistening dryness and smoothing intestines; treating dysphoria and thirst, bone steam and labor heat, cough due to lung heat, dry stool, dysuria.

Ophiopogon japonicus: Functions and indications: Nourish yin and promote body fluid, moisten the lungs and relieve cough; used for lack of fluid, thirst, dry cough and hemoptysis due to deficiency of yin in the lung and stomach;

Radix Puerariae: Commonly used for superficial syndromes of fever, stiff neck and back pain, opaque measles, fever and thirst, yin deficiency and thirst, heat diarrhea and dysentery, and diarrhea due to spleen deficiency.

Rehmannia glutinosa: It can be used for blood deficiency, chlorosis, dizziness, palpitations, insomnia, irregular menstruation, metrorrhagia, etc. It can also be used for hot flashes, night sweats, nocturnal emission, and thirst due to deficiency of kidney yin.

Huai Achyranthes bidentata: Its functions can nourish the liver and kidney, strengthen the muscles and bones, clear the meridians, and disperse evil blood. It is often used to treat cold and dampness, bone pain in the waist and knees, soreness in the waist and knees, spasms of the limbs, irregular menstrual blood, postpartum blood stasis, abdominal pain, Bleeding, bruises and knee flexion embolism.

Plantain: the whole plant of Plantaineceae plant Plantain and Flat Plantain, sweet in taste and cold in nature. It has the effects of diuresis, clearing away heat, improving eyesight, and eliminating phlegm. It is mainly used to treat obstructed urination, stranguria, leukorrhea, hematuria, jaundice, edema, hot dysentery, diarrhea, epistaxis, red eyes and swelling, sore throat, cough, and skin ulcers. Wait.

Ligusticum Chuanxiong: It is often used to promote blood circulation, expel wind and relieve pain. It has a wide range of functions in promoting blood circulation and removing blood stasis.

Salvia miltiorrhiza: It has the effects of promoting blood circulation and removing blood stasis, clearing the menstrual flow, relieving pain, clearing the heart and relieving restlessness, cooling blood and eliminating carbuncle. It is used for chest pain and heart pain, epigastric and hypochondriac pain, accumulation of lumps in the abdomen, heat arthralgia pain, upset and insomnia, irregular menstruation, dysmenorrhea closed, sores, swelling and pain.

Immortal Grass: It has the effects of regulating blood pressure, lowering blood fat, regulating blood sugar, and promoting uric acid excretion.

Angelica sinensis, Salvia miltiorrhiza, and Rhizoma chuanxiong in the present invention can nourish blood and activate blood, relieve troubles and calm the nerves, protect the kidneys, reduce nephron damage, increase renal blood flow, improve creatinine clearance, reduce monthly urea nitrogen, and have obvious effects on acute renal failure. Kidney protection; Astragalus, Poria, Ginseng, Codonopsis Atractylodes, Atractylodes macrocephala, Japonica rice, Pueraria root, and Achyranthes bidentata can invigorate qi and invigorate the spleen, protect the kidneys, and can lower blood sugar and proteinuria when used together; corn silk, anemarrhena, plantain It has a diuretic effect, and can reduce the nephrotoxic damage caused by gentamicin, and can reduce urine sugar; the herbs of fairy grass, tangerine peel, cohosh, and licorice can clear away heat and detoxify, soothe the liver and raise yang, and effectively prevent the occurrence of kidney failure.

Example 1: 10 parts of angelica, 11 parts of astragalus, 8 parts of Poria cocos, 3 parts of ginseng, 4 parts of codonopsis, 8 parts of Atractylodes macrocephala, 2 parts of corn silk, 6 parts of tangerine peel, 10 parts of cohosh, 10 parts of bupleurum, and 8 parts of licorice , 15 parts of japonica rice, 12 parts of Anemarrhena, 4 parts of Ophiopogon japonicus, 15 parts of kudzu root, 15 parts of Rehmannia glutinosa, 9 parts of Achyranthes bidentata, 15 parts of plantain, 10 parts of Chuanxiong, 10 parts of salvia miltiorrhiza, and 7 parts of fairy grass.

Example 2: 15 parts of angelica, 11 parts of astragalus, 8 parts of poria cocos, 4 parts of ginseng, 6 parts of codonopsis, 7 parts of Atractylodes macrocephala, 4 parts of corn silk, 10 parts of tangerine peel, 12 parts of cohosh, 13 parts of bupleurum, and 10 parts of licorice , 18 parts of japonica rice, 12 parts of Anemarrhena, 8 parts of Ophiopogon japonicus, 15 parts of kudzu root, 15 parts of Rehmannia glutinosa, 13 parts of Achyranthes bidentata, 10 parts of plantain, 6 parts of Chuanxiong, 8 parts of salvia miltiorrhiza, and 8 parts of fairy grass.

Example 3: 12 parts of angelica, 10 parts of astragalus, 6 parts of poria cocos, 4 parts of ginseng, 4 parts of codonopsis, 8 parts of Atractylodes macrocephala, 3 parts of corn silk, 7 parts of tangerine peel, 11 parts of cohosh, 12 parts of bupleurum, and 9 parts of licorice , 16 parts of japonica rice, 14 parts of Anemarrhena, 6 parts of Ophiopogon japonicus, 13 parts of kudzu root, 12 parts of Rehmannia glutinosa, 10 parts of Achyranthes bidentata, 11 parts of plantain, 8 parts of Chuanxiong, 9 parts of salvia miltiorrhiza, and 9 parts of fairy grass.

The above descriptions are only preferred embodiments of the present invention, and are not intended to limit the present invention in any form. Any simple modifications made to the above embodiments according to the technical essence of the present invention, equivalent changes and modifications, all belong to this invention. within the scope of the technical solution of the invention.

Claims (6)

1. The Chinese angelica and astragalus treating agent for treating early diabetic nephropathy is characterized by comprising, by mass, 10-15 parts of Chinese angelica, 8-11 parts of astragalus, 5-8 parts of poria cocos, 3-5 parts of ginseng, 3-6 parts of codonopsis pilosula, 7-10 parts of bighead atractylodes rhizome, 2-4 parts of corn stigma, 6-10 parts of dried orange peel, 10-12 parts of cimicifuga foetida, 10-13 parts of radix bupleuri, 8-10 parts of liquorice, 15-20 parts of polished round-grained rice, 12-15 parts of rhizoma anemarrhenae, 4-8 parts of radix ophiopogonis, 11-15 parts of radix puerariae, 10-15 parts of prepared rehmannia rhizome, 9-13 parts of radix achyranthis bidentatae, 10-15 parts of plantain herb, 6-10 parts of ligusticum wallichii, 8-10 parts of salvia miltiorrhiza and 7-10 parts of shenxiancao.

2. The preparation method of the angelica sinensis and astragalus membranaceus therapeutic agent for treating early diabetic nephropathy according to claim 1, wherein the preparation method of the angelica sinensis and astragalus membranaceus therapeutic agent for treating early diabetic nephropathy comprises the following steps:

the method comprises the following steps: preparing medicines: the raw materials are proportioned according to the weight of the formula, impurities of the raw materials are removed, the raw materials are cleaned and placed in a cool and dry place for natural air drying;

step two: frying: preheating a medicinal stir-frying marmite to 80-85 ℃, then putting each component in the raw materials one by one, independently stir-frying, stir-frying with slow fire until the components become brown, cooling to room temperature, and stirring and mixing all stir-fried components to obtain mixed stir-fried components;

step three: crushing: putting the mixed and fried components into a crushing device for crushing, sieving the crushed components with a 100-120-mesh sieve for 3 times, and taking undersize materials;

step four: and (3) sterilization: placing the sieved fine materials in a 60 Co-gamma radiation source, wherein the radiation intensity is 15kGy, and the radiation dose rate is 3.6kGy/h, and performing ionizing radiation to kill bacteria;

step five: subpackaging: and (3) subpackaging the sterilized fine materials below the sieve into capsules according to a certain weight to obtain the reagent.

3. The process for preparing the angelica and astragalus therapeutic agent for treating early diabetic nephropathy according to claim 2, wherein the pulverization is carried out at a low temperature.

4. The method for preparing the angelica and astragalus therapeutic agent for treating early diabetic nephropathy of claim 2, wherein the mass of the fine materials in the capsule is 0.25 g.

5. The method for preparing the angelica and astragalus treating agent for treating early diabetic nephropathy as claimed in claim 2, wherein the mathematical model of the motor used for pulverization is as follows:

T_e＝μJ(λ_dri_qs-λ_qri_ds)；

wherein,the number of pole pairs is d, q are static coordinate systems, and a motor mathematical model on an M, T coordinate system is as follows:

where e represents a parameter on the synchronous speed coordinate system.

6. The method of claim 5, wherein the voltage equation of the motor is as follows:

wherein, U_ua、U_va、U_waFor three-phase winding phase voltages, R_aResistance for each phase winding; i is_ua、I_va、I_waFor three-phase winding phase current, psi_ua、ψ_va、ψ_waThe magnetic flux linkage is a three-phase armature winding flux linkage, and p ═ d/dt is a differential operator;

the stator voltage equation of the motor is as follows:

operating potential e_A、e_B、e_CComprises the following steps:

ψ_fu、ψ_fv、ψ_fwfor each pole of the permanent magnet linkage, psi, of a three-phase winding rotor_faIs made of permanent magnet flux, L'_aIs inductance of armature winding, M'_aIs the mutual inductance between the armature windings.