CN108703782A - Handleset for hemostatic clamp - Google Patents
Handleset for hemostatic clamp Download PDFInfo
- Publication number
- CN108703782A CN108703782A CN201810853702.2A CN201810853702A CN108703782A CN 108703782 A CN108703782 A CN 108703782A CN 201810853702 A CN201810853702 A CN 201810853702A CN 108703782 A CN108703782 A CN 108703782A
- Authority
- CN
- China
- Prior art keywords
- slip ring
- latch
- operating lever
- card slot
- hemostatic clamp
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000002439 hemostatic effect Effects 0.000 title claims abstract description 25
- 210000004872 soft tissue Anatomy 0.000 abstract description 4
- 238000010586 diagram Methods 0.000 description 5
- 230000008520 organization Effects 0.000 description 4
- 230000000694 effects Effects 0.000 description 3
- 240000007643 Phytolacca americana Species 0.000 description 2
- 235000009074 Phytolacca americana Nutrition 0.000 description 2
- 238000001356 surgical procedure Methods 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 230000007704 transition Effects 0.000 description 2
- 206010052428 Wound Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- 238000007373 indentation Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000011017 operating method Methods 0.000 description 1
- 230000000472 traumatic effect Effects 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/122—Clamps or clips, e.g. for the umbilical cord
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/128—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord for applying or removing clamps or clips
- A61B17/1285—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord for applying or removing clamps or clips for minimally invasive surgery
Landscapes
- Health & Medical Sciences (AREA)
- Surgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Vascular Medicine (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Reproductive Health (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Surgical Instruments (AREA)
Abstract
The present invention relates to the hemostatic clamp technical fields of medical instrument,A kind of especially Handleset for hemostatic clamp,Include operating lever with axial slide and the slip ring being slidably arranged in operating lever,Slip ring is for driving drag-line,Latch has been outwardly protruded in operating lever,It is offered on slip ring and the matched card slot of latch,And latch is located at slip ring along the path that operating lever moves,The setting of latch and card slot is cleverly utilized in of the invention its,It realizes when pulling back slip ring using certain pulling force connecting seat being made to be detached with base of the carrier head,Slip ring also crosses the latch in operating lever together,And latch is made to be absorbed in the card slot of slip ring,And then play the role of preventing slip ring from moving forward,So as to avoid because medical staff is to the risk for being exposed to endoceliac notch pull rod and directly poking soft tissue caused by the maloperation of slip ring,Ensure the safety of operation.
Description
Technical field
The present invention relates to medical instrument hemostatic clamp technical fields, especially a kind of Handleset for hemostatic clamp.
Background technology
In clinical medicine, hemostatic clamp is a kind of hemostasis fixture for being imported into using endoscope and being used in body cavity, former
When reason is that hemostatic clamp is reached at destination organization, using the mechanical force of clip, tissue wounds or blood vessel are clamped, are played only
Blood acts on, and after wound healing, collet falls off naturally, and is excreted along alimentary canal, has its traumatic small, anthemorrhagic speed
Soon, few intercurrent disease, it is curative for effect the features such as;
Hemostatic clamp at present on the market is basic as shown in Figure 1, the hemostatic clamp of the type is at the time of surgery, by by medical staff
Slip ring 2 is pulled back, drag-line 3 is made to pull collet 9, so that the closure of collet 9 clamps destination organization, is centainly drawn in drag-line 3
After force effect, the notch pull rod 7 on 3 front end connecting seat 6 of drag-line can be detached with the connector 10 on base of the carrier head 8, to make point
Sharp notch pull rod 7 will be directly exposed in body cavity, however slip ring 2 is remained and be can move freely under current state, therewith
Also security risk is just produced, is embodied in:If medical staff due to maloperation or accidentallys run into slip ring 2 at this time, that
It may result in notch pull rod 7 to forward extend out, the sharp position of its front end indentation, there may will be soft when notch pull rod 7 stretches out
Tissue directly poke, and then cause malpractice.
Invention content
The technical problem to be solved by the present invention is to:In order to solve hemostatic clamp in the prior art be easy because medical staff mistake
Slip ring is operated or accidentally run into, causes the notch pull rod on the connecting seat after being detached with base of the carrier head to forward extend out, leads to notch
Pull rod directly pokes soft tissue, the problem of so as to cause malpractice, now provides a kind of handle group for hemostatic clamp
Part, the Handleset can together be locked when connecting seat is detached with base of the carrier head, safety when improving Clinical practice with this.
The technical solution adopted by the present invention to solve the technical problems is:A kind of Handleset for hemostatic clamp, including
Operating lever with axial slide and the slip ring being slidably arranged in operating lever, the slip ring is for driving drag-line, the operation
Latch has been outwardly protruded on bar, offered on the slip ring with the matched card slot of latch, and latch is located at slip ring along operating lever
On mobile path, when slip ring along operating lever slide backwards on latch thereon it is opposed with card slot when, latch is fallen into card slot, and
Slip ring can be limited to move forward along operating lever.
When being slided backward along operating lever for the ease of slip ring, latch can enter in card slot easily, further, described
Latch is wedge shaped, and the latch has an inclined-plane close to the side of operating lever front end.
Further, the slip ring includes slide core and the shell on the outside of slide core, and the slide core is slidably arranged in operation
In the sliding slot of bar, the shell is set in the outside of operating lever, and the slide core is fixedly connected with the casing, and the card slot is opened in cunning
On core, the latch is located in the sliding slot of operating lever.
The beneficial effects of the invention are as follows:The present invention for hemostatic clamp Handleset its latch and card slot is cleverly utilized
Setting, realize that slip ring also crosses behaviour together when being pulled back slip ring using certain pulling force connecting seat being made to be detached with base of the carrier head
Make the latch on bar, and latch is made to be absorbed in the card slot of slip ring, and then play the role of preventing slip ring from moving forward, to avoid
Because soft tissue is directly poked the endoceliac notch pull rod of being exposed to caused by the maloperation of slip ring by medical staff
Risk, it is ensured that the safety of operation.
Description of the drawings
Present invention will be further explained below with reference to the attached drawings and examples.
Fig. 1 is the schematic diagram of hemostatic clamp in the prior art;
Fig. 2 is schematic diagram of the present invention for the Handleset of hemostatic clamp;
Fig. 3 is the close-up schematic view of A in Fig. 2;
Fig. 4 is schematic diagram of the present invention for its latch of the Handleset of hemostatic clamp and card slot cooperation;
Fig. 5 is the close-up schematic view of B in Fig. 4;
Fig. 6 is schematic diagram when Handleset of the present invention for hemostatic clamp uses;
Fig. 7 is the signal when present invention is detached for notch pull rod under the Handleset use state of hemostatic clamp with connector
Figure.
In figure:1, operating lever, 1-1, sliding slot, 1-11, latch, 1-21, inclined-plane, 2, slip ring, 2-1, shell, 2-2, slide core,
2-21, card slot, 3, drag-line, 4, boost tube, 5, butt tube, 6, connecting seat, 7, notch pull rod, 8, base of the carrier head, 9, collet, 10, even
Fitting.
Specific implementation mode
In conjunction with the accompanying drawings, the present invention is further explained in detail.These attached drawings are simplified schematic diagram, only with
Illustration illustrates the basic structure of the present invention, therefore it only shows the composition relevant to the invention, direction and with reference to (for example,
Upper and lower, left and right, etc.) can be only used for helping the description to the feature in attached drawing.Therefore, it is not adopted in restrictive, sense
With detailed description below, and claimed theme is only limited by appended claims and its equivalent form
Range.
Embodiment 1
As shown in Figure 2-5, a kind of Handleset for hemostatic clamp includes operating lever 1 and cunning with axial slide 1-1
The dynamic slip ring 2 being arranged in operating lever 1, slip ring 2 have outwardly protruded latch 1-11, slip ring 2 for driving drag-line 3 in operating lever 1
On offer with the matched card slot 2-21 of latch 1-11, and latch 1-11 is located at slip ring 2 along the path that operating lever 1 moves,
When slip ring 2 along operating lever 1 slide backwards on latch 1-11 thereon it is opposed with card slot 2-21 when, latch 1-11 falls into card slot 2-21
It is interior, and slip ring 2 can be limited and moved forward along operating lever 1.
Latch 1-11 is wedge shaped, and latch 1-11 has an inclined-plane 1-21, inclined-plane 1-21 tools close to the side of 1 front end of operating lever
Body can be rendered as:Sloped inwardly by the direction of front end to the rear end of operating lever 1, when slip ring 2 is moved backward along operating lever 1, behaviour
The inclined-plane 1-21 for making latch 1-11 on bar 1 can be contacted with slip ring 2 first, and using the transition of inclined-plane 1-21, latch 1-11 will produce
Flexible deformation appropriate makes latch 1-11 be between slip ring 2 and operating lever 1, when slip ring 2 is moved rearwardly into card along operating lever 1
When tooth 1-11 is opposed with slip ring 2, the extruding that latch 1-11 loses slip ring 2 restores to the original state and is trapped in card slot 2-21;And it is current
Under state, slip ring 2 can not be moved forward to push notch pull rod 7, because, when slip ring 2 is moved forward along operating lever 1,
The trailing flank of latch 1-11 can first be contacted with card slot 2-21, due to wedge-shaped latch 1-11 rear side simultaneously slope-less as transition, because
The rear side of this card slot 2-21 can apply the trailing flank of latch 1-11 the active force for making it generate tilting trend, that is to say, that can hinder
Slip ring 2 is hindered to move forward.
Slip ring 2 includes that slide core 2-2 and the shell 2-1 on the outside of slide core 2-2, slide core 2-2 are slidably arranged in operating lever 1
In sliding slot 1-1, shell 2-1 is set in the outside of operating lever 1, and slide core 2-2 is fixedly connected with shell 2-1, and card slot 2-21 is opened in
On slide core 2-2, latch 1-11 is located in the sliding slot 1-1 of operating lever 1, when it is implemented, sliding slot 1-1 is preferably two and difference position
In the both sides of slide core 2-2, same latch 1-11 is preferably also two and is located at two inner walls of 1 upper hopper chute 1-1 of operating lever
On.
As shown in fig. 6, the Handleset for hemostatic clamp in the present embodiment is when in use:The slide core 2-2 of its slip ring 2 is logical
It crosses boost tube 4 and the tail end of drag-line 3 is fixed, the head end of drag-line 3 is fixed by the notch pull rod 7 in butt tube 5 and connecting seat 6,
The gap portions of notch pull rod 7 are stuck on the connector 10 being fixedly connected with collet 9 in base of the carrier head 8;
As shown in fig. 7, operating procedure is as follows in the course of surgery for the hemostatic clamp with the Handleset in the present embodiment:It is first
First collet 9 is imported into body cavity by endoscope, and collet 9 is made to be at endoceliac destination organization, subsequent medical staff
Pull back slip ring 2 along operating lever 1, make drag-line 3 pull collet 9, so as to collet 9 closure destination organization is clamped, drag-line 3 by
To after certain pulling force effect, the notch pull rod 7 on 3 front end connecting seat 6 of drag-line can be detached with the connector 10 on base of the carrier head 8, and
Slip ring 2 can also cross the latch 1-11 in operating lever 1 together, and latch 1-11 is made to be trapped in the card slot 2-21 of slip ring 2, to
Limit is moved to the negative direction of card slot 2-21 using latch 1-11, plays the role of preventing slip ring 2 from moving forward, so as to avoid
Because soft tissue is directly poked the endoceliac notch pull rod 7 that is exposed to caused by the maloperation of slip ring 2 by medical staff
Risk, it is ensured that the safety of operation.
Above-mentioned desirable embodiment according to the present invention is enlightenment, and through the above description, relevant staff is complete
Can various changes and amendments be carried out without departing from the scope of the technological thought of the present invention'.This invention it is technical
Range is not limited to the contents of the specification, it is necessary to determine its technical scope according to right.
Claims (3)
1. a kind of Handleset for hemostatic clamp, includes operating lever (1) with axial slide (1-1) and be slidably arranged in behaviour
Make the slip ring (2) on bar (1), the slip ring (2) is for driving drag-line (3), it is characterised in that:On the operating lever (1) outward
It is protruding with latch (1-11), is offered on the slip ring (2) and latch (1-11) matched card slot (2-21), and latch (1-
11) it is located at slip ring (2) along the mobile path of operating lever (1), when slip ring (2) slides backwards on card thereon along operating lever (1)
When tooth (1-11) is opposed with card slot (2-21), latch (1-11) is fallen into card slot (2-21), and can limit slip ring (2) along operating lever
(1) it moves forward.
2. the Handleset according to claim 1 for hemostatic clamp, it is characterised in that:The latch (1-11) is in wedge
Shape, the latch (1-11) have an inclined-plane (1-21) close to the side of operating lever (1) front end.
3. the Handleset according to claim 1 for hemostatic clamp, it is characterised in that:The slip ring (2) includes slide core
(2-2) and the shell (2-1) on the outside of slide core (2-2), the slide core (2-2) are slidably arranged in the sliding slot (1- of operating lever (1)
1) in, the shell (2-1) is set in the outside of operating lever (1), and the slide core (2-2) is fixedly connected with shell (2-1), described
Card slot (2-21) is opened in slide core (2-2), and the latch (1-11) is located in the sliding slot (1-1) of operating lever (1).
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201810853702.2A CN108703782B (en) | 2018-07-30 | 2018-07-30 | Handle assembly for hemostatic clip |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201810853702.2A CN108703782B (en) | 2018-07-30 | 2018-07-30 | Handle assembly for hemostatic clip |
Publications (2)
Publication Number | Publication Date |
---|---|
CN108703782A true CN108703782A (en) | 2018-10-26 |
CN108703782B CN108703782B (en) | 2024-06-25 |
Family
ID=63875547
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201810853702.2A Active CN108703782B (en) | 2018-07-30 | 2018-07-30 | Handle assembly for hemostatic clip |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN108703782B (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110236613A (en) * | 2019-06-14 | 2019-09-17 | 毛张凡 | Intracavity operation instrument |
CN110664445A (en) * | 2019-11-05 | 2020-01-10 | 江苏唯德康医疗科技有限公司 | Tissue drag hook and medical retractor with same |
US11793535B2 (en) | 2018-03-28 | 2023-10-24 | Zhangfan Mao | Endoluminal surgery device |
Citations (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2000254143A (en) * | 1999-03-08 | 2000-09-19 | Asahi Optical Co Ltd | Hemostasis clip device for endoscope |
JP2005218683A (en) * | 2004-02-06 | 2005-08-18 | Pentax Corp | Operation part of holding forceps for endoscope |
CN1917820A (en) * | 2004-12-07 | 2007-02-21 | 奥林巴斯株式会社 | Insertion apparatus for endoscope |
JP2007125264A (en) * | 2005-11-07 | 2007-05-24 | Pentax Corp | Clip removal instrument for endoscope |
CN201299593Y (en) * | 2008-11-28 | 2009-09-02 | 常州市久虹医疗器械有限公司 | Composite outer tube biopsy forceps |
JP2010183936A (en) * | 2009-02-10 | 2010-08-26 | Fujifilm Corp | Rapid-succession clip processing instrument, clip package, and package for the same |
US20130211432A1 (en) * | 2010-09-22 | 2013-08-15 | FUJIJFILM Corporation | Ligation device and clip unit used therein |
CN104095659A (en) * | 2013-04-10 | 2014-10-15 | 山东威高集团医用高分子制品股份有限公司 | Lockable thumb push-pull slide block biopsy forceps |
CN204581354U (en) * | 2015-03-26 | 2015-08-26 | 中国人民解放军南京军区南京总医院 | A kind of disposable endoscope biopsy forceps |
CN204600544U (en) * | 2015-04-20 | 2015-09-02 | 江苏安特尔医疗科技有限公司 | Locking type disposable endoscope biopsy forceps |
JP2015192724A (en) * | 2014-03-31 | 2015-11-05 | 日本ゼオン株式会社 | Hold releasing device of body tissue holding member |
KR101754026B1 (en) * | 2016-04-29 | 2017-07-04 | 금오공과대학교 산학협력단 | Biopsy forceps for endoscope |
CN206507994U (en) * | 2016-11-28 | 2017-09-22 | 张慧 | A kind of scope tissue hemostatic clamp |
KR101851115B1 (en) * | 2018-01-17 | 2018-05-30 | 최원준 | Endoscope disposable clip treatment device |
CN209018848U (en) * | 2018-07-30 | 2019-06-25 | 江苏唯德康医疗科技有限公司 | Handleset for hemostatic clamp |
-
2018
- 2018-07-30 CN CN201810853702.2A patent/CN108703782B/en active Active
Patent Citations (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2000254143A (en) * | 1999-03-08 | 2000-09-19 | Asahi Optical Co Ltd | Hemostasis clip device for endoscope |
JP2005218683A (en) * | 2004-02-06 | 2005-08-18 | Pentax Corp | Operation part of holding forceps for endoscope |
CN1917820A (en) * | 2004-12-07 | 2007-02-21 | 奥林巴斯株式会社 | Insertion apparatus for endoscope |
JP2007125264A (en) * | 2005-11-07 | 2007-05-24 | Pentax Corp | Clip removal instrument for endoscope |
CN201299593Y (en) * | 2008-11-28 | 2009-09-02 | 常州市久虹医疗器械有限公司 | Composite outer tube biopsy forceps |
JP2010183936A (en) * | 2009-02-10 | 2010-08-26 | Fujifilm Corp | Rapid-succession clip processing instrument, clip package, and package for the same |
US20130211432A1 (en) * | 2010-09-22 | 2013-08-15 | FUJIJFILM Corporation | Ligation device and clip unit used therein |
CN104095659A (en) * | 2013-04-10 | 2014-10-15 | 山东威高集团医用高分子制品股份有限公司 | Lockable thumb push-pull slide block biopsy forceps |
JP2015192724A (en) * | 2014-03-31 | 2015-11-05 | 日本ゼオン株式会社 | Hold releasing device of body tissue holding member |
CN204581354U (en) * | 2015-03-26 | 2015-08-26 | 中国人民解放军南京军区南京总医院 | A kind of disposable endoscope biopsy forceps |
CN204600544U (en) * | 2015-04-20 | 2015-09-02 | 江苏安特尔医疗科技有限公司 | Locking type disposable endoscope biopsy forceps |
KR101754026B1 (en) * | 2016-04-29 | 2017-07-04 | 금오공과대학교 산학협력단 | Biopsy forceps for endoscope |
CN206507994U (en) * | 2016-11-28 | 2017-09-22 | 张慧 | A kind of scope tissue hemostatic clamp |
KR101851115B1 (en) * | 2018-01-17 | 2018-05-30 | 최원준 | Endoscope disposable clip treatment device |
CN209018848U (en) * | 2018-07-30 | 2019-06-25 | 江苏唯德康医疗科技有限公司 | Handleset for hemostatic clamp |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11793535B2 (en) | 2018-03-28 | 2023-10-24 | Zhangfan Mao | Endoluminal surgery device |
CN110236613A (en) * | 2019-06-14 | 2019-09-17 | 毛张凡 | Intracavity operation instrument |
CN110664445A (en) * | 2019-11-05 | 2020-01-10 | 江苏唯德康医疗科技有限公司 | Tissue drag hook and medical retractor with same |
Also Published As
Publication number | Publication date |
---|---|
CN108703782B (en) | 2024-06-25 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP1706040B1 (en) | Implantable graft to close a fistula | |
CN108703782A (en) | Handleset for hemostatic clamp | |
CN103190939B (en) | There is the endoscope operation applicator of clip retention | |
CN107115130B (en) | Double-sliding-groove self-locking hemostatic clamp | |
JP4960257B2 (en) | Delivery system | |
CN209018848U (en) | Handleset for hemostatic clamp | |
CN209884245U (en) | Medical hemostatic clamp | |
EP3967243A1 (en) | A biopsy forceps and a jaw assembly thereof | |
JP7162727B2 (en) | Double-lumen end caps used in quarry baskets and quarry baskets | |
CN110251186A (en) | A kind of chuck structure of endoscope-use tissue folder | |
CN107137119A (en) | A kind of closing clamp and its method for releasing | |
JP2011147551A (en) | Catheter and catheter insertion instrument | |
CN217365980U (en) | Nonmagnetic hemostatic clamp used in cooperation with endoscope | |
CN207755321U (en) | A kind of closing clamp | |
JPS6214811Y2 (en) | ||
CN114699132A (en) | Mechanical releasing device and releasing method for surgical implant | |
CN113262010A (en) | Conveying mechanism of aneurysm plugging device | |
CN207755322U (en) | A kind of release device of closing clamp | |
CN217723574U (en) | Detachable liquid bag magnetic traction device | |
CN221431166U (en) | Automatic ligation device for endoscope polyp | |
CN114983503B (en) | Disposable movable tongue double-arm clamp for full-layer suture | |
CN219538577U (en) | CSVD rat model blood vessel administration assembly | |
JP7154521B2 (en) | local injection needle | |
KR102353604B1 (en) | Hybrid Sphincterotome | |
CN111904591B (en) | Multifunctional scalpel for digestive endoscopy ERCP operation |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
GR01 | Patent grant | ||
GR01 | Patent grant |