CN108567854A - Join Ling oral liquid and preparation method thereof - Google Patents
Join Ling oral liquid and preparation method thereof Download PDFInfo
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- A61K36/484—Glycyrrhiza (licorice)
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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Abstract
Seed ginseng Ling oral liquid of the invention and preparation method thereof, belongs to technical field of traditional Chinese medicines；It is prepared by the raw material of following weight：22 27 parts of Radix Notoginseng, 18 23 parts of American Ginseng, 26 32 parts of ganoderma lucidum, 35 45 parts of matrimony vine, 24 parts of sika deer velvet antler, 7 12 parts of Radix Astragali, 7 12 parts of Radix Glycyrrhizae；The present invention joins Ling oral liquid, and preparation method is simple, fully takes into account the abundant extraction of various drug ingedients in composition, immunity of organisms can effectively be enhanced, and present composition compatibility is reasonable, each raw material used has played synergistic effect, and drug activity is substantially better than each single raw material.
Description
Technical field
Seed ginseng Ling oral liquid of the invention and preparation method thereof, belongs to technical field of traditional Chinese medicines.
Background technology
Immunity is the defense mechanism of human body itself, is that human bioequivalence and any foreign matter of the external intrusion of elimination are (viral, thin
Bacterium etc.)；It handles aging, damage, death, the own cells of denaturation and identification and processing vivo mutations cell and virus infection is thin
The ability of born of the same parents.The body of hypoimmunity easily incurs the infection such as bacterium, virus, fungi, therefore hypoimmunity is most direct
Performance is exactly liable to illness.
The human body of health has natural resistance to bacterium and virus, only the feelings of functional disturbance occurs in human organ
Under condition, bacterium or virus could invade and cause to fall ill.Therefore improving immunity of human body itself could be constantly to antiviral
Invasion.And effectively Chinese medicine composition has the effect of allomeric function state of adjustment body, raising immunity of organisms.
Invention content
Overcome the deficiencies in the prior art of the present invention, it is a kind of with raising human immunity the technical problem to be solved is that providing
Ginseng Ling oral liquid of power and preparation method thereof.
In order to solve the above technical problems, the technical solution adopted in the present invention is：One seed ginseng Ling oral liquid, by following weight
The raw material of part proportioning is prepared：22-27 parts of Radix Notoginseng, 18-23 parts of American Ginseng, 26-32 parts of ganoderma lucidum, 35-45 parts of matrimony vine, sika deer
It is 2-4 parts fine and soft, 7-12 parts of Radix Astragali, 7-12 parts of Radix Glycyrrhizae.
Preferably, it is prepared by the raw material of following weight：25 parts of Radix Notoginseng, 20 parts of American Ginseng, 30 parts of ganoderma lucidum,
40 parts of matrimony vine, 3 parts of sika deer velvet antler, 10 parts of Radix Astragali, 10 parts of Radix Glycyrrhizae.
The pharmacological property of each raw material is as follows in the present invention：
Radix Notoginseng：Also known as it is invaluable, enrich blood first, the ginseng with tonifying Qi first, taste is most precious person in Chinese medicine also with work(.
For Araliaceae herbaceos perennial, sweet in flavor, slight bitter is warm-natured, and principle active component is notoginsenoside, has hemostasis stasis, disappears
The effect of swollen analgesic therapy.
American Ginseng：Belong to Araliaceae Panax, belong to one kind of ginseng, is the drug of first choice of qi-tonifying health-care, sweet in flavor, slight bitter,
It is cold in nature, containing there are many ginsenoside, volatile oil, carbohydrate, amino acid and inorganic elements etc., can anti anoxia, it is antifatigue, enhance machine
The adaptability and immune function of body, can anti-arrhythmia, adjust blood pressure, effectively enhance nervous centralis, can beneficial lung yin, clearly
The fire of deficiency type promotes the production of body fluid to quench thirst.
Ganoderma lucidum：Chemical composition mainly has a triterpene compound, polysaccharide, ucleosides, alkaloids, amino acid polypeptide class,
Inorganic elements, aliphatic acid etc..Polysaccharide is one of bioactive substance of ganoderma lucidum, has antitumor, immunological regulation, hypoglycemic, drop
Blood fat, anti-oxidant and anti-aging effect.
Radix Astragali：Property sweet tepor, be tonifying Qi good medicine, stress qi-restoratives, main component is glycoside, flavonoids, polysaccharide, amino acid
Deng with solid table, liver protection diuresis, decompression antibacterial, anti-aging, resisting stress, enhancing body's immunity.
Radix Glycyrrhizae：Belong to pulse family, gas is micro-, sweet and special, and main component has glycyrrhizic acid, liquiritin etc., glycyrrhizin and Huang
Letones are most important physiological activators in Radix Glycyrrhizae, have the effect of clearing heat and detoxicating, expelling phlegm and arresting coughing.
Matrimony vine：Main component is glycine betaine, and atropine, hyoscyamine, wolfberry pigment etc., wherein polysaccharides are in matrimony vine
Most important active constituent is a kind of water-soluble polysaccharide, and there is antifatigue, antitumor, anti-aging, radioresistance, liver protection to promote to exempt from
The effect of epidemic disease.
Sika deer velvet antler：To mend marrow, kidney yang is helped, strengthening the bones and muscles effect and famous, the salty temperature of property sugariness have abundant amino
Acid, vitamin and trace element, health-care effect are very high.
A method of ginseng Ling oral liquid is prepared, is included the following steps：
(1) ultrasonic lixiviating effective components-total saposins after taking the Radix Notoginseng of weight, American Ginseng to crush；It will crush first
The weight ratio of Radix Notoginseng afterwards, American Ginseng petroleum ether and extracting n-butyl alcohol, liquid material used is 33:1, petroleum ether and n-butanol used
Concentration be 49.5%, the volume ratio of petroleum ether and n-butanol used is 1:1；Then again with a concentration of 70% EtOH Sonicate
Extraction, ultrasonic time are 28min/ times, and ultrasonic extraction 2 times, ultrasonic temperature is 50 DEG C, obtains saponin(e dry cream；
(2) ganoderma lucidum of weight, sika deer velvet antler, matrimony vine, Radix Astragali, licorice medicinal materials, through crushing using a concentration of are taken
The weight ratio of 99.5% petroleum ether, liquid material used is 25:1, it impregnates grease removal for 24 hours, is then extracted with sevage reagents to remove
Albumen, is eventually adding a concentration of 75% ethyl alcohol, alcohol precipitation ultrasound lixiviating effective components-total starches, and the weight ratio of liquid material used is
25:1, the volume ratio of ethyl alcohol used and sevage reagents is 1：1, ultrasonic temperature is 75 DEG C, and ultrasonic time is 30min/ times, is surpassed
Sound extracts 2 times, obtains polysaccharide extraction liquid；
(3) the saponin(e dry cream obtained by step (1) is mixed with the polysaccharide extraction liquid obtained by step (2), is concentrated into liquid-solid ratio
It is 1.2:When 1, clarified solution is obtained with sedimentation separation method；
(4) into clarified solution obtained by step (3), addition flavouring agent joins Ling oral liquid to obtain the final product；The flavouring agent is by following weight
The raw material composition of part proportioning：1 part of citric acid, 25 parts of honey, 35 parts of xylitol；
The prepared Ling oral liquid relative density of joining of step (4) is 1.17, PH 4.5, general flavone 1.13%, and total reducing sugar is
14.23%, the clarification of product sepia, uniform color is consistent, palatable free from extraneous odour.
Sevage reagents described in step (2) are chloroform and a concentration of 99% n-butanol is 5 by volume：1 mixing institute
.
Compared with prior art the invention has the advantages that.
The present invention joins Ling oral liquid, and preparation method is simple, fully takes into account fully carrying for various drug ingedients in composition
It takes, can effectively enhance immunity of organisms, and present composition compatibility is reasonable, each raw material used has played synergistic effect, medicine
Effect activity is substantially better than each single raw material.
Specific implementation mode
Below in conjunction with specific embodiment, the invention will be further described.
Embodiment 1
One seed ginseng Ling oral liquid, is prepared by the raw material of following weight：22 parts of Radix Notoginseng, 23 parts of American Ginseng, spirit
26 parts of sesame, 45 parts of matrimony vine, 2 parts of sika deer velvet antler, 12 parts of Radix Astragali, 7 parts of Radix Glycyrrhizae.
A method of ginseng Ling oral liquid is prepared, is included the following steps：
(1) ultrasonic lixiviating effective components-total saposins after taking the Radix Notoginseng of weight, American Ginseng to crush；It will crush first
Radix Notoginseng afterwards, American Ginseng petroleum ether and extracting n-butyl alcohol, the solid weight ratio of liquid used are 33:1, petroleum ether and n-butanol used
Concentration be 49.5%, the volume ratio of petroleum ether and n-butanol used is 1:1；Then again with a concentration of 70% EtOH Sonicate
Extraction, ultrasonic time are 28min/ times, and ultrasonic extraction 2 times, ultrasonic temperature is 50 DEG C, obtains saponin(e dry cream；
(2) ganoderma lucidum of weight, sika deer velvet antler, matrimony vine, Radix Astragali, licorice medicinal materials, through crushing using a concentration of are taken
99.5% petroleum ether, the solid weight ratio of liquid used are 25:1, it impregnates grease removal for 24 hours, is then extracted with sevage reagents to remove
Albumen, is eventually adding a concentration of 75% ethyl alcohol, alcohol precipitation ultrasound lixiviating effective components-total starches, and the solid weight ratio of liquid used is
25:1, the volume ratio of ethyl alcohol used and sevage reagents is 1：1, ultrasonic temperature is 75 DEG C, and ultrasonic time is 30min/ times, is surpassed
Sound extracts 2 times, obtains polysaccharide extraction liquid；The sevage reagents are chloroform and a concentration of 99% n-butanol is 5 by volume：
1 mixing gained；
(3) the saponin(e dry cream obtained by step (1) is mixed with the polysaccharide extraction liquid obtained by step (2), is concentrated into liquid-solid ratio
It is 1.2:When 1, clarified solution is obtained with sedimentation separation method；
(4) into clarified solution obtained by step (3), addition flavouring agent joins Ling oral liquid to obtain the final product；The flavouring agent is by following weight
The raw material composition of part proportioning：1 part of citric acid, 25 parts of honey, 35 parts of xylitol；
Prepared ginseng Ling oral liquid relative density be 1.17, PH 4.5, general flavone 1.13%, total reducing sugar 14.23%,
Product sepia is clarified, and uniform color is consistent, palatable free from extraneous odour.
Embodiment 2
One seed ginseng Ling oral liquid, is prepared by the raw material of following weight：27 parts of Radix Notoginseng, 18 parts of American Ginseng, spirit
32 parts of sesame, 35 parts of matrimony vine, 4 parts of sika deer velvet antler, 7 parts of Radix Astragali, 12 parts of Radix Glycyrrhizae.
A method of ginseng Ling oral liquid being prepared, with embodiment 1.
Embodiment 3
One seed ginseng Ling oral liquid, is prepared by the raw material of following weight：25 parts of Radix Notoginseng, 20 parts of American Ginseng, spirit
30 parts of sesame, 40 parts of matrimony vine, 3 parts of sika deer velvet antler, 10 parts of Radix Astragali, 10 parts of Radix Glycyrrhizae.
A method of ginseng Ling oral liquid being prepared, with embodiment 1.
Test example
The effect of to examine the present invention to improve immunity, test mouse.
Test example 1, influence experiment of the present composition to mouse immune organ thymus gland, spleen weight.
Mouse (14~18g) 40 is taken, is randomly divided into 4 groups, blank control group and treatment group.Treatment group is given respectively to implement
Ginseng Ling oral liquid prepared by example 1,2,3；Blank control group gives isometric physiological saline.It is 0.2ml/ to give volume
10g, 1 times/day of gavage, continuous gavage 10 days, the next day after last gavage put to death mouse, weigh, take spleen, thymus gland, liver
Claim weight in wet base, using the ratio between weight (mg) and weight (g) of thymus gland or spleen as thymus gland or spleen index.
Test result：
Join influence of the Ling oral liquid to mouse thymus index and spleen index
Note：The * P ＜ 0.05 compared with blank group, * * P ＜ 0.01.
As seen from the above table, the ginseng Ling oral liquid of three embodiments of the invention can improve the spleen index of mouse and thymus gland refers to
There are pole significant difference in number, treatment group three compared with the control group；One treatment group two for the treatment of group significant difference compared with the control group
It is different.
Test example 2, ConA inducing mouse Splenic vein hemodynamics experiment (mtt assay)
Gavage and grouping are sterile to each group mouse that spleen, splenocyte suspension processed is taken to be trained completely with RPMI1640 with test example 1
Nutrient solution adjusts a concentration of 3*10 of splenocyte9A/L carries out lymphproliferation response according to mtt assay in program, finally in 752 purples
It is outer see at spectrophotometer 570nm wavelength survey its absorbance value (A), calculate ConA+ and each holes ConA- absorbance.Each dosage
Group result carry out variance analysis compared with blank control group.As a result it see the table below：
Note：Compared with the control group, * P ＜ 0.05, * * P ＜ 0.01
As seen from the above table, the ginseng Ling oral liquid prepared by embodiment 1-3 has significant difference (P compared with the control group<
0.05), illustrate that present invention ginseng Ling oral liquid can promote ConA inducing mouse Splenic vein hemodynamics.
The present invention can be summarized with others without prejudice to the concrete form of the spirit or essential characteristics of the present invention.Therefore, nothing
By from the point of view of which point, the embodiment above of the invention can only all be considered the description of the invention and cannot limit invention,
Claims indicate the scope of the present invention, and above-mentioned explanation does not point out the scope of the present invention, therefore, with the present invention
The comparable meaning and scope of claims in any variation, be all considered as being included within the scope of the claims.
Claims (4)
1. a seed ginseng Ling oral liquid, which is characterized in that be prepared by the raw material of following weight：22-27 parts of Radix Notoginseng, west
18-23 parts of American ginseng, 26-32 parts of ganoderma lucidum, 35-45 parts of matrimony vine, 2-4 parts of sika deer velvet antler, 7-12 parts of Radix Astragali, 7-12 parts of Radix Glycyrrhizae.
2. ginseng Ling oral liquid according to claim 1, which is characterized in that by the raw material preparation of following weight
At：25 parts of Radix Notoginseng, 20 parts of American Ginseng, 30 parts of ganoderma lucidum, 40 parts of matrimony vine, 3 parts of sika deer velvet antler, 10 parts of Radix Astragali, 10 parts of Radix Glycyrrhizae.
3. a kind of method preparing ginseng Ling oral liquid as described in claim 1, which is characterized in that include the following steps：
(1) ultrasonic lixiviating effective components-total saposins after taking the Radix Notoginseng of weight, American Ginseng to crush；It first will be after crushing
The weight ratio of Radix Notoginseng, American Ginseng petroleum ether and extracting n-butyl alcohol, liquid material used is 33:1, petroleum ether and n-butanol used it is dense
Degree is 49.5%, and the volume ratio of petroleum ether and n-butanol used is 1:1；Then it is soaked again with a concentration of 70% EtOH Sonicate
It carries, ultrasonic time is 28min/ times, and ultrasonic extraction 2 times, ultrasonic temperature is 50 DEG C, obtains saponin(e dry cream；
(2) ganoderma lucidum of weight, sika deer velvet antler, matrimony vine, Radix Astragali, licorice medicinal materials, through crushing using a concentration of 99.5% are taken
Petroleum ether, the weight ratio of liquid material used is 25:1, it impregnates grease removal for 24 hours, is then extracted to remove deproteinized, most with sevage reagents
A concentration of 75% ethyl alcohol is added afterwards, the weight ratio of alcohol precipitation ultrasound lixiviating effective components-total starches, liquid material used is 25:1, institute
It is 1 with the volume ratio of ethyl alcohol and sevage reagents：1, ultrasonic temperature is 75 DEG C, and ultrasonic time is 30min/ times, ultrasonic extraction 2
It is secondary, obtain polysaccharide extraction liquid；
(3) the saponin(e dry cream obtained by step (1) is mixed with the polysaccharide extraction liquid obtained by step (2), being concentrated into liquid-solid ratio is
1.2:When 1, clarified solution is obtained with sedimentation separation method；
(4) into clarified solution obtained by step (3), addition flavouring agent joins Ling oral liquid to obtain the final product；The flavouring agent is matched by following parts by weight
The raw material of ratio forms：1 part of citric acid, 25 parts of honey, 35 parts of xylitol；
The prepared Ling oral liquid relative density of joining of step (4) is 1.17, PH 4.5, general flavone 1.13%, and total reducing sugar is
14.23%, the clarification of product sepia, uniform color is consistent, palatable free from extraneous odour.
4. a kind of method preparing ginseng Ling oral liquid according to claim 3, which is characterized in that described in step (2)
Sevage reagents are chloroform and a concentration of 99% n-butanol is 5 by volume：1 mixing gained.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111991474A (en) * | 2020-09-07 | 2020-11-27 | 深圳市桦健量子生物科技有限公司 | Lucid ganoderma oral liquid and preparation method thereof |
| CN113186065A (en) * | 2021-04-26 | 2021-07-30 | 吉林大清鹿苑保健科技有限公司 | Health wine for enhancing immunity and preparation method thereof |
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| CN101385772A (en) * | 2008-01-09 | 2009-03-18 | 姜宝库 | Effervescence tablets for increasing natural immunity |
| CN101664185A (en) * | 2009-09-07 | 2010-03-10 | 北京同仁堂健康药业股份有限公司 | Food and medicament for enhancing immunity and relieving physical fatigue and preparation method |
| CN101816355A (en) * | 2010-02-22 | 2010-09-01 | 李宏良 | Anti-fatigue alternative tea and preparation method thereof |
| CN104055935A (en) * | 2014-07-08 | 2014-09-24 | 朱正来 | Traditional Chinese medicine composition for improving immunity in synergetic mode |
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2017
- 2017-10-11 CN CN201710941478.8A patent/CN108567854A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101385772A (en) * | 2008-01-09 | 2009-03-18 | 姜宝库 | Effervescence tablets for increasing natural immunity |
| CN101664185A (en) * | 2009-09-07 | 2010-03-10 | 北京同仁堂健康药业股份有限公司 | Food and medicament for enhancing immunity and relieving physical fatigue and preparation method |
| CN101816355A (en) * | 2010-02-22 | 2010-09-01 | 李宏良 | Anti-fatigue alternative tea and preparation method thereof |
| CN104055935A (en) * | 2014-07-08 | 2014-09-24 | 朱正来 | Traditional Chinese medicine composition for improving immunity in synergetic mode |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111991474A (en) * | 2020-09-07 | 2020-11-27 | 深圳市桦健量子生物科技有限公司 | Lucid ganoderma oral liquid and preparation method thereof |
| CN113186065A (en) * | 2021-04-26 | 2021-07-30 | 吉林大清鹿苑保健科技有限公司 | Health wine for enhancing immunity and preparation method thereof |
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