CN108348568B - 抗炎肽及其用途 - Google Patents
抗炎肽及其用途 Download PDFInfo
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- CN108348568B CN108348568B CN201680051932.6A CN201680051932A CN108348568B CN 108348568 B CN108348568 B CN 108348568B CN 201680051932 A CN201680051932 A CN 201680051932A CN 108348568 B CN108348568 B CN 108348568B
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- peptide
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- arg
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Abstract
本发明公开了一种抗炎肽，其包含选自SEQUENCE ID NO:1‑16的蛋白质的抗炎片段，该抗炎片段的长度为7至37个氨基酸并且具有‑9至+3的电荷；其中c‑末端氨基酸不是半胱氨酸(C)或蛋氨酸(M)，并且n‑末端氨基酸不是半胱氨酸(C)、组氨酸(H)、脯氨酸(P)或苏氨酸(T)。抗炎片段不包含半胱氨酸(C)。抗炎片段来自SEQUENCE ID NO:1‑16的蛋白质的区域，该区域特征在于长度为17至109个氨基酸并且具有‑6至+4的电荷，其中该区域的c‑末端氨基酸不是天冬氨酸(D)、苯丙氨酸(F)、蛋氨酸(M)或色氨酸(W)，且该区域的n‑末端氨基酸不是天冬氨酸(D)、组氨酸(H)、蛋氨酸(M)、脯氨酸(P)或色氨酸(W)。在SEQUENCE ID NO:71‑221中提供了肽的实例。
Description
背景技术
据估计，全世界惊人地有20亿人患有某种类型的炎症(inflammation)。炎症是一个巨大的生物过程并且是我们免疫反应的必要组成部分。炎症反应可以是急性的(短暂的)或慢性的(更持久的)，并且可以发生在身体的几乎每一个部位，无论它是在内部还是外部。此外，有趣的是，无论炎症的起因如何，炎症反应所致的身体内发生的生物学变化在整个身体中是相同的，这意味着不同抗炎剂所具有的减少炎症的模式在身体的所有部位都是相同的。
通常，炎症是一种自然反应，也是使细胞摆脱损伤原因、外来侵袭或清除死亡细胞的必要反应。然而，过度的炎症对人体有很大影响，以及有时会有不利影响。实际上，炎症反应可能具有持久的不良后果，例如组织损伤。在炎症反应期间，身体释放溶酶体酶，其可以破坏组织并且甚至可能导致危及生命的超敏反应。这些病况在外部和内部均可产生持久的影响，在外部发生急性皮疹和湿疹，在体内引发诸如炎性肠病的疾病。因此，维持正常的炎症水平对我们的身心健康是非常重要的，无论是体内还是体外。不幸的是，炎症正在增加。这种增加的主要因素之一来自我们暴露于越来越多的我们身体所不习惯的外部试剂。
当今使用的大多数抗炎治疗是药物。有两种主要类型的抗炎药，皮质类固醇(corticosteroids)和非甾体类抗炎药(NSAID)。这些包括：免疫抑制剂(甲氨蝶呤、环孢素)；特定的生物药物(主要是TNF-α抑制剂，但还包括例如环氧合酶的抑制剂)；细胞毒性药物；和口服类维生素A(阿维A)。此外，还有专门减少皮肤炎症的局部治疗。实例包括乳膏和软膏(主要基于可的松)，和物理治疗，如紫外线辐射。然而，这些药物具有强烈的副作用，例如胃肠毒性和类过敏反应。它们甚至可以将免疫系统抑制到容易受其它疾病和病原体影响的程度。
因此，很明确的是需要确定具有抗炎活性的试剂，其不会免疫抑制和/或引起其它不良副作用。为此，已知一些非常特殊类型的食物可以减少炎症(Kiecolt-Glaser J.K.等人，2010，Middleton E.等人，2000，Chatterjee M.等人，2005)。实际上，这些特殊食物的特定成分是低浓度、隐性或锁住(lock away)的，并且一旦被识别和解锁，就可以按照认可的方式被放大以特异性地靶向炎症，因为我们的身体了解食物的成分并能够很容易地处理这些分子。实际上，这些特定的食物分子可以减少炎症，而不会完全阻断这种免疫系统反应，使身体处于脆弱状态。同样地对于那些对多种食物过敏的人来说，识别和解锁可减少炎症的食物的特定成分将允许这些个体获得他们原本会过敏的食物的抗炎益处。
本发明的目的是克服至少一个上述问题。
发明内容
豌豆基因组编码了超过70,000种不同蛋白质。申请人已经鉴定了这些蛋白质中的七种，其中的每一种均含有一种或多种抗炎片段。同样地，在由水稻基因组(rice genome)编码的超过60,000种蛋白质中，本申请人鉴定了八种蛋白质，其中的每一种均含有一种或多种抗炎片段。当与LPS刺激的人细胞一起孵育时，已证实16种鉴定的蛋白质的抗炎片段具有抗炎活性(图1至19)，不会引起人类细胞活力问题(图20)，并且对人类细胞没有毒性(图21)。从其衍生天然肽的特定植物蛋白质在SEQUENCE ID NO：1-15和353-355中提供，特别是来自在SEQUENCE ID NO：17-69中提供的蛋白质的区域。从其衍生肽的特定豌豆蛋白质在SEQUENCE ID NO：1-5、8和9中提供，而从其衍生肽的特定大米蛋白质(rice protein)在SEQUENCE ID NO：6、7和10-15中提供。这些蛋白质的同源物在SEQUENCE ID NO：222-267中描述。最初在豌豆蛋白质中鉴定的特定肽在SEQUENCE ID NO：71-107和110-111中示出。最初在大米蛋白质中鉴定的特定肽在SEQUENCE ID NO：108-109和112-220中示出。本文提供了本发明的在豌豆和大米蛋白质中鉴定的另外的肽，例如提供在SEQUENCE ID NO：320、331-352和356-424中。本发明的肽涵盖含有或由任何上述肽组成的肽。
EWQINEK(SEQ ID 331)-SEQ ID 7的大米蛋白质的片段
FLPQHTD(SEQ ID 332)-SEQ ID 1的豌豆蛋白质的片段
GPQQYAEWQINEK(SEQ ID 333)-SEQ ID 7的大米蛋白质的片段
PGQLQSFLLSGN(SEQ ID 334)-SEQ ID 1的豌豆蛋白质的片段
PGQLQSFLLSGNQNQQNYLSGF(SEQ ID 335)-SEQ ID 1的豌豆蛋白质的片段
PQQYAEWQ(SEQ ID 336)-SEQ ID 7的大米蛋白质的片段
QLQSFLLSGNQNQQNYLSGFSK(SEQ ID 337)-SEQ ID 1的豌豆蛋白质的片段
QNQQNYLSGFSK(SEQ ID 338)-SEQ ID 1的豌豆蛋白质的片段
QSFLLSGNQNQQ(SEQ ID 339)-sEQ ID 1的豌豆蛋白质的片段
QSFLLSGNQ(SEQ ID 340)-SEQ ID 1的豌豆蛋白质的片段
RGPQQYA(SEQ ID 341)-SEQ ID 7的大米蛋白质的片段
DALEPDNR(SEQ ID 342)-SEQ ID 354的豌豆蛋白质的片段
SEEGYYGEQQQQPGMTR(SEQ ID 343)-SEQ ID 353的大米蛋白质的片段
GYYGEQQQQPGMTR(SEQ ID 344)SEQ ID 353的大米蛋白质的片段
IDGYDTPVEGR(SEQ ID 345)-SEQ ID 15的大米蛋白质的片段
NGVLRPGQL(SEQ ID 346)-SEQ ID 14的大米蛋白质的片段
RHGEWGPSY(SEQ ID 347)
FWM(SEQ ID 348)-SEQ ID 3的豌豆蛋白质的片段
TVFDGVLRPGQL[SEQ ID 349]-SEQ ID 10的大米蛋白质的片段
RLQSQNDQRGEIIHVK[SEQ ID 350]-SEQ ID 10的大米蛋白质的片段
HGPVEMPYTLLYPSSK[SEQ ID 351]-SEQ ID 355的豌豆蛋白质的片段
LDALEPDNR[SEQ ID 352]-SEQ ID 354的豌豆蛋白质的片段
RGPQQYAEWQINE[SEQ ID 320]-SEQ ID 7的大米蛋白质的片段
本发明的肽主要用于使炎症减轻，因此可用于预防或治疗炎性病况和维持哺乳动物的肠道健康。
在第一方面，本发明提供了一肽，其长度通常为3至50个氨基酸，并且包含本文公开的蛋白质的片段，例如选自SEQUENCE ID NO:1-16、349或350或其同源物的片段，或所述肽的变体或片段(以下称“本发明的肽”)。在一个实施方案中，肽或其变体或片段具有生物活性。在一个实施方案中，肽或其变体或片段具有抗炎活性。
在一个实施方案中，本发明的肽包含选自SEQUENCE ID NO:17-220、268-352和356-424的序列。
在一个实施方案中，本发明的肽基本上由选自SEQUENCE ID NO:17-220、268-352和356-424的序列组成。
在一个实施方案中，肽由3-50个氨基酸组成。在一个实施方案中，肽由4-50个氨基酸组成。在一个实施方案中，肽由5-50个氨基酸组成。在一个实施方案中，肽由6-50个氨基酸组成。
在一个实施方案中，所述片段具有7至37个氨基酸和-9至+3之间的电荷。
优选地，c-末端氨基酸不是半胱氨酸(C)或蛋氨酸(M)。
优选地，n-末端氨基酸不是半胱氨酸(C)、组氨酸(H)、脯氨酸(P)或苏氨酸(T)。
优选地，片段的c-末端结构域不含半胱氨酸(C)。
优选地，片段的n-末端结构域不含半胱氨酸(C)。
优选地，片段不含半胱氨酸(C)。
优选地，肽不含半胱氨酸(C)。
优选地，片段来自SEQUENCE ID NO:1-16的蛋白质的区域，该区域由以下特征表征：
-长度为17至109个氨基酸；
-电荷在-6至+4之间；
-c-末端氨基酸不是天冬氨酸(D)、苯丙氨酸(F)、蛋氨酸(M)或色氨酸(W)；
-n-末端氨基酸不是天冬氨酸(D)、组氨酸(H)、蛋氨酸(M)、脯氨酸(P)或色氨酸(W)。
优选地，该区域的c-末端结构域不含色氨酸(W)。
优选地，SEQUENCE ID NO:1-7的蛋白质的区域选自SEQUENCE ID NO:17-33。
优选地，SEQUENCE ID NO:8-16的蛋白质的区域选自SEQUENCE ID NO:34-70。
优选地，SEQUENCE ID NO:1-16的蛋白质的区域选自SEQUENCE ID NO:17-70。
优选地，片段是选自SEQUENCE ID NO:71-221，或片段的变体。
优选地，肽由选自SEQUENCE ID NO:71-221的片段或该片段的变体组成。
优选地，肽由选自SEQUENCE ID NO:71-221的序列组成。
在一个实施方案中，肽包含豌豆蛋白质的片段，其中该片段选自SEQUENCE ID NO:71-107、332、334、335、337-340、342、348和351-352。
在一个实施方案中，肽包含豌豆蛋白质的片段，其中该片段选自SEQUENCE ID NO:71-107、332、334、335、337-340、342、348和351-352。在一个实施方案中，该片段选自339、352、351、93、92、75、76、105。
在一个实施方案中，肽包含大米蛋白质的片段，其中该片段选自SEQUENCE ID NO:108-109、112-220、320、331、333、336、341、343-346、349-350。在一个实施方案中，该片段选自341、144、320、349、350、177、343-346。
在一个实施方案中，肽是经修饰的肽。在一个实施方案中，肽被保护基团修饰。在一个实施方案中，肽被修饰以增加其亲脂性。在一个实施方案中，肽被修饰以增加其半衰期。在一个实施方案中，肽的N-末端或C-末端氨基酸被修饰。在一个实施方案中，肽的N-末端或C-末端氨基酸被保护基修饰。
本发明还提供了包含缀合至结合配偶体(binding partner)的本发明肽的缀合物。在一个实施方案中，本发明的肽被反应基团修饰，该反应基团配置为允许与结合配偶体缀合。
[SEQUENCE ID NO:1(豌豆蛋白质1)]
优选地，肽包含SEQUENCE ID NO:1的蛋白质的生物活性片段，或其同源物，或该蛋白质片段的生物活性变体。
优选地，肽包含SEQUENCE ID NO:1的七个区域之一的生物活性片段，即SEQUENCEID NO:17-23，或该蛋白质片段的生物活性变体。
优选地，肽包含选自SEQUENCE ID NO:71-91或360的生物活性片段，或该蛋白质片段的生物活性变体。
优选地，肽包含SEQUENCE ID NO:17的区域的片段，例如SEQUENCE ID NO:71，或该蛋白质片段的生物活性变体。
优选地，肽包含SEQUENCE ID NO:18的区域的生物活性片段，例如SEQUENCE IDNO:72，或该片段的生物活性变体。
优选地，肽包含SEQUENCE ID NO:19的区域的生物活性片段，例如SEQUENCE IDNO:73或74中的任何一个或二者，或该片段的生物活性变体。
优选地，肽包含SEQUENCE ID NO:20的区域的生物活性片段，例如SEQUENCE IDNO:75或76中的任何一个或二者，或该片段的生物活性变体。
优选地，肽包含SEQUENCE ID NO:21的区域的生物活性片段，例如SEQUENCE IDNO:77-84中的一个或多个或全部，或该片段的生物活性变体。
优选地，肽包含SEQUENCE ID NO:22的区域的生物活性片段，例如SEQUENCE IDNO:85-89中的一个或多个或全部，或该片段的生物活性变体。
优选地，肽包含SEQUENCE ID NO:23的区域的生物活性片段，例如SEQUENCE IDNO:90，或该片段的生物活性变体。
优选地，肽包含SEQUENCE ID NO:91，或该片段的生物活性变体。
本发明还提供了包含本发明的至少一种肽的组合物，所述肽包含SEQUENCE IDNO:1的片段或其同源物。本发明还提供了包含本发明的至少2种，优选为3种，优选为4种，优选为5种，优选为6种，优选为7种，优选为8种，优选为9种或优选为10种肽的组合物，其中的每一种包含SEQUENCE ID NO:1的不同片段或其同源物。优选地，肽或多种肽是生物活性的。优选地，肽或多种肽是抗炎的。优选地，组合物包含本发明的第一肽和本发明的第二肽，所述第一肽包含选自SEQUENCE ID NO:17-23的第一区域的片段，所述第二肽包含选自SEQUENCE ID NO:17-23的第二区域的片段。优选地，组合物包含第一生物活性肽(其包含选自SEQUENCE ID NO:71-91的第一生物活性片段(或该片段的生物活性变体))，和第二生物活性肽(其包含选自SEQUENCE ID NO:71-91的第二生物活性片段(或该片段的生物活性变体))。
豌豆蛋白质1(SEQUENCE ID NO:1)的同源物包括蚕豆(Vicia fabia)、鹰嘴豆(Cicerarietinum)和兵豆(Lens culinaris)同源物(SEQ ID NO:222-224)。
[SEQUENCE ID NO:2(豌豆蛋白质2)]
优选地，肽包含SEQUENCE ID NO:2的蛋白质的生物活性片段，或其同源物。
优选地，肽包含SEQUENCE ID NO:2的两个区域之一的生物活性片段，即SEQUENCEID NO:24或25。
优选地，肽包含SEQUENCE ID NO:24的区域的生物活性片段，例如SEQUENCE IDNO:92，或该片段的生物活性变体。
优选地，肽包含SEQUENCE ID NO:25的区域的生物活性片段，例如SEQUENCE IDNO:93，或该片段的生物活性变体。
本发明还提供了包含本发明的至少一种生物活性肽的组合物，所述肽包含SEQUENCE ID NO:2的生物活性片段或其同源物。本发明还提供了包含本发明的至少两种生物活性肽的组合物，每种肽包含SEQUENCE ID NO:2的不同生物活性片段或其同源物。优选地，组合物包含含有SEQUENCE ID NO 24的区域的生物活性片段的第一生物活性肽和含有SEQUENCE ID NO 25的区域的生物活性片段的第二生物活性肽。优选地，组合物包含含有SEQUENCE ID NO 92的生物活性片段的第一生物活性肽和含有SEQUENCE ID NO 93的生物活性片段的第二生物活性肽。
豌豆蛋白质2(SEQUENCE ID NO:2)的同源物包括兵豆(Lens culinaris)、法国野豌豆(Vicia narbonensis)和大豆(Glycine max)(SEQ ID NO:225-227)。
[SEQUENCE ID NO:3(豌豆蛋白质3)]
优选地，肽包含SEQUENCE ID NO:3的蛋白质的生物活性片段，或其同源物。
优选地，肽包含SEQUENCE ID NO:3的两个区域之一的生物活性片段，即SEQUENCEID NO:26或27。
优选地，肽包含SEQUENCE ID NO:26的区域的生物活性片段，例如SEQUENCE IDNO:94，或该片段的生物活性变体。
优选地，肽包含SEQUENCE ID NO:27的区域的生物活性片段，例如SEQUENCE IDNO:95，或该片段的生物活性变体。
本发明还提供了一种至少包含本发明的生物活性肽的组合物，所述肽包含SEQUENCE ID NO:3的生物活性片段或其同源物。本发明还提供了一种包含本发明的至少两种生物活性肽的组合物，其中每一种肽包含SEQUENCE ID NO:3的不同生物活性片段或其同源物。优选地，组合物包含含有SEQUENCE ID NO 26的区域的生物活性片段的第一肽和含有SEQUENCE ID NO 27的生物活性片段的第二肽。优选地，组合物包含含有SEQUENCE ID NO94的生物活性片段(或该片段的生物活性变体)的第一生物活性肽和包含SEQUENCE ID NO95的生物活性片段(或该片段的生物活性变体)的第二生物活性肽。
豌豆蛋白质3(SEQUENCE ID NO:3)的同源物包括箭筈豌豆(Vicia sativa)、蒺藜苜蓿(Medicago truncatula)和百脉根(Lotus japonicas)(SEQ ID NO:228-230)。
[SEQUENCE ID NO:4(豌豆蛋白质4)]
优选地，肽包含SEQUENCE ID NO:4的蛋白质的生物活性片段，或其同源物。
优选地，肽包含SEQUENCE ID NO:4的五个区域之一的生物活性片段，即SEQUENCEID NO:28-32。优选地，区域是SEQUENCE ID NO:28，优选为SEQUENCE ID NO:29，优选为SEQUENCE ID NO:30，优选为SEQUENCE ID NO:31，优选为SEQUENCE ID NO:32。
优选地，肽包含SEQUENCE ID NO:28的区域的生物活性片段，例如SEQUENCE IDNO:96，或该片段的生物活性变体。
优选地，肽包含SEQUENCE ID NO:29的区域的生物活性片段，例如SEQUENCE IDNO:97-103，或该片段的生物活性变体。
优选地，肽包含SEQUENCE ID NO:30的区域的生物活性片段，例如SEQUENCE IDNO:104，或该片段的生物活性变体。
优选地，肽包含SEQUENCE ID NO:31的区域的生物活性片段，例如SEQUENCE IDNO:105，或该片段的生物活性变体。
优选地，肽包含SEQUENCE ID NO:32的区域的生物活性片段，例如SEQUENCE IDNO:106，或该片段的生物活性变体。
本发明还提供了一种包含本发明的至少一种生物活性肽的组合物，所述肽包含SEQUENCE ID NO:4的生物活性片段或其同源物。本发明还提供了一种包含本发明的至少2种，优选为3种，优选为4种，优选为5种，优选为6种，优选为7种，优选为8种，优选为9种或优选为10种含有SEQUENCE ID NO:4的不同生物活性片段或其同源物的肽的组合物。优选地，组合物包含含有选自SEQUENCE ID NO:28-32的第一区域的生物活性片段的第一肽，和含有选自SEQUENCE ID NO:28-32的第二区域的生物活性片段的第二肽。优选地，组合物包含第一生物活性肽(其包含选自SEQUENCE ID NO:96-106的第一生物活性片段(或该片段的生物活性变体))，和第二生物活性肽(其包含选自SEQUENCE ID NO:96-106的第二生物活性片段(或该片段的生物活性变体))。
豌豆蛋白质4(SEQUENCE ID NO:4)的同源物包括埃塞俄比亚豌豆(Pisumabyssinicum)、山黧豆葵(Lathyrus annuus)和长柔毛野豌豆(Vicia villosa)(SEQ ID231-233)。
[SEQUENCE ID NO:5(豌豆蛋白质5)]
优选地，肽包含SEQUENCE ID NO:5的蛋白质的生物活性片段，或其同源物。
优选地，肽包含SEQUENCE ID NO:5的区域的生物活性片段，即SEQUENCE ID NO 33的区域，例如SEQUENCE ID NO:107，或该片段的生物活性变体。
本发明还提供了一种包含本发明的至少一种生物活性肽的组合物，所述肽包含SEQUENCE ID NO:5的生物活性片段或其同源物。本发明还提供了一种包含本发明的至少两种肽的组合物，其包含SEQUENCE ID NO:5的至少一种生物活性片段或其同源物，例如SEQUENCE ID NO:107。
豌豆蛋白质5(SEQUENCE ID NO:5)的同源物包括蒺藜苜蓿(Medicagotruncatula)、游隼野豌豆(Vicia peregrine)和黄花豌豆(Vicia lutea)(SEQ ID NO:234-236)。
[SEQUENCE ID NO:6(大米蛋白质7-Q6K508)]
优选地，肽包含SEQUENCE ID NO:6的蛋白质的生物活性片段，或其同源物。
优选地，肽包含SEQUENCE ID NO:108的生物活性片段，或该片段的生物活性变体。
本发明还提供了一种包含本发明的至少一种生物活性肽的组合物，所述肽包含SEQUENCE ID NO:6的生物活性片段或其同源物。本发明还提供了一种包含本发明的至少两种肽的组合物，其包含SEQUENCE ID NO:6的至少一种生物活性片段或其同源物，例如SEQUENCE ID NO:108(SP1)。
大米蛋白质7(SEQUENCE ID NO:6)的同源物包括短花药野生稻(Oryzabrachyantha)、燕麦(Avena sativa)和二穗短柄草(Brachypodium distachyon)(SEQ IDNO:237-239)。
[SEQUENCE ID NO:7(大米蛋白质8-Q6K7K6)]
优选地，肽包含SEQUENCE ID NO:7的蛋白质的生物活性片段或其同源物。
优选地，肽包含SEQUENCE ID NO:109(SP2)的生物活性片段，或该片段的生物活性变体。
本发明还提供了一种包含本发明的至少一种生物活性肽的组合物，所述肽包含SEQUENCE ID NO:7的生物活性片段或其同源物。本发明还提供了一种包含本发明的至少两种肽的组合物，其包含SEQUENCE ID NO:7的至少一种生物活性片段或其同源物，例如SEQUENCE ID NO:109(SP2)。
大米蛋白质8(SEQUENCE ID NO:7)的同源物包括粳稻组水稻(Oryza sativaJaponica Group)、籼稻组水稻(Oryza sativa Indica Group)和短花药野生稻(Oryzabrachyantha)(SEQ ID NO:240-242)。
[SEQUENCE ID NO:8(豌豆蛋白质6-P13919)]
优选地，肽包含SEQUENCE ID NO:8的蛋白质的生物活性片段或其同源物。
优选地，肽包含SEQUENCE ID NO:110(SP3)的生物活性片段，或该片段的生物活性变体。
本发明还提供了一种包含本发明的至少一种生物活性肽的组合物，所述肽包含SEQUENCE ID NO:8的生物活性片段或其同源物。本发明还提供了一种包含本发明的至少两种肽的组合物，其包含SEQUENCE ID NO:8的至少一种生物活性片段或其同源物，例如SEQUENCE ID NO:110(SP3)。
豌豆蛋白质8(SEQUENCE ID NO:8)的同源物包括豌豆野生种(Pisum fulvum)、埃塞俄比亚豌豆(Pisum abyssinicum)和长柔毛野豌豆(Vicia villosa)(SEQ ID NO:243-245)。
[SEQUENCE ID NO:9(豌豆蛋白质7-P02855)]
优选地，肽包含SEQUENCE ID NO:9的蛋白质的生物活性片段，或其同源物。
优选地，肽包含SEQUENCE ID NO:111(SP4)的生物活性片段，或该片段的生物活性变体。
本发明还提供了一种包含本发明的至少一种生物活性肽的组合物，所述肽包含SEQUENCE ID NO:9的生物活性片段或其同源物。本发明还提供了一种包含本发明的至少两种肽的组合物，其包含SEQUENCE ID NO:9的至少一种生物活性片段或其同源物，例如SEQUENCE ID NO:111(SP4)。
豌豆蛋白质9(SEQUENCE ID NO:9)的同源物包括硬毛山黧豆(Lathyrushirsutus)、扁荚山黧豆(Lathyrus cicero)、家山黧豆(Lathyrus sativus)(SEQ ID NO:246-248)。
[SEQUENCE ID NO:10(大米蛋白质1-P07728)]
优选地，肽包含SEQUENCE ID NO:10的蛋白质的生物活性片段，或其同源物。
优选地，肽包含SEQUENCE ID NO:10的九个区域之一的片段，即SEQUENCE ID NO:34-42。优选地，该区域是SEQUENCE ID NO:34，优选为SEQUENCE ID NO:35，优选为SEQUENCEID NO:36，优选为SEQUENCE ID NO:37，优选为SEQUENCE ID NO:38，优选为SEQUENCE IDNO:39，优选为SEQUENCE ID NO:40，优选为SEQUENCE ID NO:41，优选为SEQUENCE ID NO:42。
优选地，肽包含SEQUENCE ID NO:34的区域的生物活性片段，例如SEQUENCE IDNO:112或SEQUENCE ID NO:113，或该片段的生物活性变体。
优选地，肽包含SEQUENCE ID NO:35的区域的生物活性片段，例如SEQUENCE IDNO:114，或该片段的生物活性变体。
优选地，肽包含SEQUENCE ID NO:36的区域的生物活性片段，例如SEQUENCE IDNO:115或SEQUENCE ID NO:116，或该片段的生物活性变体。
优选地，肽包含SEQUENCE ID NO:37的区域的生物活性片段，例如SEQUENCE IDNO:117或SEQUENCE ID NO:118，或该片段的生物活性变体。
优选地，肽包含SEQUENCE ID NO:38的区域的生物活性片段，例如SEQUENCE IDNO:119，或该片段的生物活性变体。
优选地，肽包含SEQUENCE ID NO:39的区域的生物活性片段，例如SEQUENCE IDNO:120、121或122，或该片段的生物活性变体。
优选地，肽包含SEQUENCE ID NO:40的区域的生物活性片段，例如SEQUENCE IDNO:123，或该片段的生物活性变体。
优选地，肽包含SEQUENCE ID NO:41的区域的生物活性片段，例如SEQUENCE IDNO:124、125、126、127、128或129，或该片段的生物活性变体。
优选地，肽包含SEQUENCE ID NO:42的区域的片段，例如SEQUENCE ID NO:130、131或132，或该片段的生物活性变体。
本发明还提供了一种包含本发明的至少一种生物活性肽的组合物，所述肽包含SEQUENCE ID NO:10的生物活性片段或其同源物。本发明还提供了一种包含本发明的至少2种，优选为3种，优选为4种，优选为5种，优选为6种，优选为7种，优选为8种，优选为9种或优选为10种肽的组合物，每种肽包含SEQUENCE ID NO:10的不同生物活性片段或其同源物。优选地，组合物包含含有选自SEQUENCE ID NO:34-42的第一区域的生物活性片段的第一肽，和含有选自SEQUENCE ID NO:34-42的第二区域的生物活性片段的第二肽。优选地，组合物包含第一生物活性肽(其包含选自SEQUENCE ID NO:112-132的第一生物活性片段(或该片段的生物活性变体))，和第二生物活性肽(其包含选自SEQUENCE ID NO:112-132的第二生物活性片段(或该片段的生物活性变体))。
大米蛋白质1(SEQUENCE ID NO:10)的同源物包括短花药野生稻(Oryzabrachyantha)和菰(Zizania latifolia)(SEQ ID NO:249-251)。
[SEQUENCE ID NO:11(大米蛋白质2-P07728)]
优选地，肽包含SEQUENCE ID NO:11的蛋白质的生物活性片段，或其同源物。
优选地，肽包含SEQUENCE ID NO:11的四个区域之一的生物活性片段，即SEQUENCEID NO:43-46。优选地，该区域是SEQUENCE ID NO:43，优选为SEQUENCE ID NO:44，优选为SEQUENCE ID NO:45，优选为SEQUENCE ID NO:46。
优选地，肽包含SEQUENCE ID NO:43的区域的生物活性片段，例如SEQUENCE IDNO:133，或该片段的生物活性变体。
优选地，肽包含SEQUENCE ID NO:44的区域的生物活性片段，例如SEQUENCE IDNO:134-137，或该片段的生物活性变体。
优选地，肽包含SEQUENCE ID NO:45的区域的生物活性片段，例如SEQUENCE IDNO:138-144，或该片段的生物活性变体。
优选地，肽包含SEQUENCE ID NO:46的区域的生物活性片段，例如SEQUENCE IDNO:145，或该片段的生物活性变体。
本发明还提供了一种包含本发明的至少一种生物活性肽的组合物，所述肽包含SEQUENCE ID NO:11的生物活性片段或其同源物。本发明还提供了一种包含本发明的至少2种，优选为3种，优选为4种，优选为5种，优选为6种，优选为7种，优选为8种，优选为9种或优选为10种肽的组合物，其中每种肽包含SEQUENCE ID NO:11的生物活性片段或其同源物。优选地，组合物包含含有选自SEQUENCE ID NO:43-46的第一区域的生物活性片段的第一肽，和含有选自SEQUENCE ID NO:43-46的第二区域的生物活性片段的第二肽。优选地，组合物包含第一生物活性肽(其包含选自SEQUENCE ID NO:133-145的第一生物活性片段(或该片段的生物活性变体))，和第二生物活性肽(其包含选自SEQUENCE ID NO:133-145的第二生物活性片段(或该片段的生物活性变体))。
大米蛋白质2(SEQUENCE ID NO:11)的同源物包括籼稻组水稻(Oryza sativaIndica Group)、菰(Zizania latifolia)、燕麦(Avena sativa)(SEQ ID NO:252-254)。
[SEQUENCE ID NO:12(大米蛋白质3-P07730)]
优选地，肽包含SEQUENCE ID NO:12的蛋白质的生物活性片段，或其同源物。
优选地，肽包含SEQUENCE ID NO:12的八个区域之一的生物活性片段，即SEQUENCEID NO:47-54。优选地，该区域是SEQUENCE ID NO:47，优选为SEQUENCE ID NO:48，优选为SEQUENCE ID NO:49，优选为SEQUENCE ID NO:50，优选为SEQUENCE ID NO:51，优选为SEQUENCE ID NO:52，优选为SEQUENCE ID NO:53，优选为SEQUENCE ID NO:54。
优选地，肽包含SEQUENCE ID NO:47的区域的生物活性片段，例如SEQUENCE IDNO:146-150，或该片段的生物活性变体。
优选地，肽包含SEQUENCE ID NO:48的区域的生物活性片段，例如SEQUENCE IDNO:151-157之一，或该片段的生物活性变体。
优选地，肽包含SEQUENCE ID NO:49的区域的生物活性片段，例如SEQUENCE IDNO:158或SEQUENCE ID NO:159之一，或该片段的生物活性变体。
优选地，肽包含SEQUENCE ID NO:50的区域的生物活性片段，例如SEQUENCE IDNO:160-162之一，或该片段的生物活性变体。
优选地，肽包含SEQUENCE ID NO:51的区域的生物活性片段，例如SEQUENCE IDNO:163或164之一，或该片段的生物活性变体。
优选地，肽包含SEQUENCE ID NO:52的区域的生物活性片段，例如SEQUENCE IDNO:165，或该片段的生物活性变体。
优选地，肽包含SEQUENCE ID NO:53的区域的生物活性片段，例如SEQUENCE IDNO:166-171之一，或该片段的生物活性变体。
优选地，肽包含SEQUENCE ID NO:54的区域的生物活性片段，例如SEQUENCE IDNO:172-176之一，或该片段的生物活性变体。
本发明还提供了一种包含本发明的至少一种生物活性肽的组合物，所述肽包含SEQUENCE ID NO:12的生物活性片段或其同源物。本发明还提供了一种包含本发明的至少2种，优选为3种，优选为4种，优选为5种，优选为6种，优选为7种，优选为8种，优选为9种或优选为10种肽的组合物，其中每种肽包含SEQUENCE ID NO:12的生物活性片段或其同源物。优选地，组合物包含含有选自SEQUENCE ID NO:47-54的第一区域的生物活性片段的第一肽，和含有选自SEQUENCE ID NO:47-54的第二区域的生物活性片段的第二肽。优选地，组合物包含第一生物活性肽(其包含选自SEQUENCE ID NO:146-172的第一生物活性片段(或该片段的生物活性变体))，和第二生物活性肽(其包含选自SEQUENCE ID NO:146-172的第二抗炎片段(或该片段的生物活性变体))。
大米蛋白质3(SEQUENCE ID NO:12)的同源物包括短花药野生稻(Oryzabrachyantha)、二穗短柄草(Brochypodium distachyon)(SEQ ID NO:255-257)。
[SEQUENCE ID
NO:13(大米蛋白质4-Q0D7S0)]
优选地，肽包含SEQUENCE ID NO:13的蛋白质的生物活性片段，或其同源物。
优选地，肽包含SEQUENCE ID NO:13的区域的生物活性片段，即SEQUENCE ID NO55，例如SEQUENCE ID NO:177，或该片段的生物活性变体。
本发明还提供了一种包含本发明的至少一种生物活性肽的组合物，所述肽包含SEQUENCE ID NO:13的生物活性片段或其同源物。本发明还提供了一种包含本发明的至少两种肽的组合物，其中的至少一种肽包含SEQUENCE ID NO:13的生物活性片段或其同源物，例如SEQUENCE ID NO:177，或该片段的生物活性变体。
大米蛋白质4(SEQUENCE ID NO:13)的同源物包括籼稻组水稻(Oryza sativaIndica Group)、菰(Zizania latifolia)、燕麦(Avena sativa)(SEQ ID NO:252-254)。
[SEQUENCEIDNO:14(大米蛋白质5-P14614)]
优选地，肽包含SEQUENCE ID NO:14的蛋白质的片段，或其同源物。
优选地，肽包含SEQUENCE ID NO:14的七个区域之一的生物活性片段，即SEQUENCEID NO:56-62。优选地，该区域是SEQUENCE ID NO:56，优选为SEQUENCE ID NO:57，优选为SEQUENCE ID NO:58，优选为SEQUENCE ID NO:59，优选为SEQUENCE ID NO:60，优选为SEQUENCE ID NO:61，优选为SEQUENCE ID NO:62。
优选地，肽包含SEQUENCE ID NO:56的区域的生物活性片段，例如SEQUENCE IDNO:178-180之一，或该片段的生物活性变体。
优选地，肽包含SEQUENCE ID NO:57的区域的生物活性片段，例如SEQUENCE IDNO:181-182之一，或该片段的生物活性变体。
优选地，肽包含SEQUENCE ID NO:58的区域的生物活性片段，例如SEQUENCE IDNO:183，或该片段的生物活性变体。
优选地，肽包含SEQUENCE ID NO:59的区域的生物活性片段，例如SEQUENCE IDNO:184-190之一，或该片段的生物活性变体。
优选地，肽包含SEQUENCE ID NO:60的区域的生物活性片段，例如SEQUENCE IDNO:191，或该片段的生物活性变体。
优选地，肽包含SEQUENCE ID NO:61的区域的生物活性片段，例如SEQUENCE IDNO:192-195之一，或该片段的生物活性变体。
优选地，肽包含SEQUENCE ID NO:62的区域的生物活性片段，例如SEQUENCE IDNO:196-197之一，或该片段的生物活性变体。
本发明还提供了一种包含本发明的至少一种生物活性肽的组合物，所述肽包含SEQUENCE ID NO:14的生物活性片段或其同源物。本发明还提供了一种包含本发明的至少2种，优选为3种，优选为4种，优选为5种，优选为6种，优选为7种，优选为8种，优选为9种或优选为10种肽的组合物，其中每种肽包含SEQUENCE ID NO:14的生物活性片段或其同源物。优选地，组合物包含含有选自SEQUENCE ID NO:56-62的第一区域的生物活性片段的第一肽，和含有选自SEQUENCE ID NO:56-62的第二区域的生物活性片段的第二肽。优选地，组合物包含第一生物活性肽(其包含选自SEQUENCE ID NO:178-197的第一生物活性片段(或该片段的生物活性变体))，和第二生物活性肽(其包含选自SEQUENCE ID NO:178-197的第二生物活性片段(或该片段的生物活性变体))。
大米蛋白质5(SEQUENCE ID NO:14)的同源物包括粳稻组水稻(Oryza sativaJaponica Group)、二穗短柄草(Brochypodium distachyon)(SEQ ID NO:261-263)。
[SEQUENCEIDNO:15(大米蛋白质6-Q0DEV5)]
优选地，肽包含SEQUENCE ID NO:15的蛋白质的生物活性片段，或其同源物。
优选地，肽包含SEQUENCE ID NO:15的七个区域之一的生物活性片段，即SEQUENCEID NO:63-67。优选地，该区域是SEQUENCE ID NO:63，优选为SEQUENCE ID NO:64，优选为SEQUENCE ID NO:65，优选为SEQUENCE ID NO:66，优选为SEQUENCE ID NO:67。
优选地，肽包含SEQUENCE ID NO:63的区域的片段，例如SEQUENCE ID NO:198-200之一，或该片段的生物活性变体。
优选地，肽包含SEQUENCE ID NO:64的区域的片段，例如SEQUENCE ID NO:201-203之一，或该片段的生物活性变体。
优选地，肽包含SEQUENCE ID NO:65的区域的片段，例如SEQUENCE ID NO:204，或该片段的生物活性变体。
优选地，肽包含SEQUENCE ID NO:66的区域的片段，例如SEQUENCE ID NO:205-208之一，或该片段的生物活性变体。
优选地，肽包含SEQUENCE ID NO:67的区域的片段，例如SEQUENCE ID NO:209-215之一，或该片段的生物活性变体。
优选地，肽包含SEQUENCE ID NO:68的区域的片段，例如SEQUENCE ID NO:216-219之一，或该片段的生物活性变体。
优选地，肽包含SEQUENCE ID NO:69的区域的片段，例如SEQUENCE ID NO:220，或该片段的生物活性变体。
本发明还提供了一种包含本发明的至少一种生物活性肽的组合物，所述肽包含SEQUENCE ID NO：15的生物活性片段或其同源物。本发明还提供了一种包含本发明的至少2种，优选为3种，优选为4种，优选为5种，优选为6种，优选为7种，优选为8种，优选为9种，或优选为10种肽的组合物，其中每种肽包含SEQUENCE ID NO：15的生物活性片段或其同源物。优选地，组合物包含含有选自SEQUENCE ID NO：63-69的第一区域的生物活性片段的第一肽，和含有选自SEQUENCE ID NO：63-69的第二区域的生物活性片段的第二肽。优选地，组合物包含第一生物活性肽(其包含选自SEQUENCE ID NO：198-220的第一生物活性片段(或该片段的生物活性变体))，和第二生物活性肽(其包含选自SEQUENCE ID NO：198-220的第二生物活性片段(或该片段的生物活性变体))。
大米蛋白质6(SEQUENCE ID NO：15)的同源物包括普通野生稻(Oryzarufipogon)、药用野生稻(Oryza officinaliS)、青稞(Hordeum vulgare subSp.vulgare)(SEQ ID NO：264-266)。
[SEQUENCE ID NO：16(细菌蛋白质1-P0C1U8)]
优选地，肽包含SEQUENCE IDNO：16的蛋白质的生物活性片段，或其同源物。
优选地，肽包含SEQUENCE ID NO：16的区域的生物活性片段，即SEQUENCE ID NO70的区域。通常，肽是SEQUENCE ID NO 221，或该片段的生物活性变体。
本发明还提供了一种包含本发明的至少一种生物活性肽的组合物，所述肽包含SEQUENCE ID NO：16的生物活性片段或其同源物。本发明还提供了一种包含本发明的至少两种肽的组合物，其中的至少一种肽包含SEQUENCE ID NO：16的片段或其同源物，例如SEQUENCE ID NO：212，或该片段的生物活性变体。
细菌蛋白质1(SEQUENCE IDNO：16)的同源物包括：
＞gi|580560623|gb|EVF84961.1|谷氨酰内肽酶 [金黄色葡萄球菌 COAS6020]
＞gi|580687002|gb|EVH10169.1|谷氨酰内肽酶 [金黄色葡萄球菌 UCIM6080]
＞gi|751815683|gb|KIN24957.1|谷氨酰内肽酶 [金黄色葡萄球菌 MRSA_CVM43477]
＞gi|781884797|dbj|BAR08486.1|谷氨酰内肽酶前体 [金黄色葡萄球菌金黄色亚种 1
＞gi| 781887762|dbj|BAR11210.1|谷氨酰内肽酶前体 [金黄色葡萄球菌金黄色亚种]
本发明还提供了包含至少一种且优选为多种本发明的生物活性肽的生物活性组合物，其中本发明的每种肽包含本文所描述的蛋白质的生物活性片段。在一个实施方案中，蛋白质选自SEQUENCE ID NO：1-16。通常，本发明的所述肽或每种肽选自，或包含一生物活性片段，所述生物活性片段选自，SEQUENCE ID NO：71-220，或所述片段的生物活性变体。
在一个实施方案中，组合物包含本发明的肽，所述肽包括选自SEQUENCE ID NO：17-220、268-352和356-424的序列。
在一个实施方案中，组合物包含本发明的肽，所述肽基本上由选自SEQUENCE IDNO:17-220、268-352和356-424的序列组成。
通常，本发明的所述肽或每种肽选自，或包含一生物活性片段，所述生物活性片段选自，SEQUENCE ID NO:71-107和110-111，或所述片段的生物活性变体。
通常，本发明的所述肽或每种肽选自，或包含一抗炎片段，所述抗炎片段选自SEQUENCE ID NO:108-109和112-220，或所述片段的抗炎变体。
在一个实施方案中，本发明的生物活性肽、变体或片段是抗炎的。
优选地，组合物包含本发明的至少两种不同的肽。
优选地，组合物包含本发明的至少三种不同的肽。
优选地，组合物包含本发明的至少四种不同的肽。
优选地，组合物包含本发明的至少五种不同的肽。
优选地，组合物包含本发明的至少六种不同的肽。
优选地，组合物包含本发明的至少七种不同的肽。
优选地，组合物包含本发明的至少八种不同的肽。
优选地，组合物包含本发明的至少九种不同的肽。
优选地，组合物包含本发明的至少十种不同的肽。
在一个实施方案中，本发明包括一种组合物，所述组合物包含SEQUENCE ID NO:71-107和110-111中的一种或多种，或片段的抗炎变体，或抗炎片段和变体的混合物。
在一个实施方案中，组合物包含SEQUENCE ID NO 75、91、92、93、110和111中的至少一种、两种、三种、四种、五种或全部。
在一个实施方案中，组合物包含基本上全部片段SEQUENCE ID NO:71-107和110-111。
在一个实施方案中，本发明包括一种组合物，所述组合物包含SEQUENCE ID NO:108-109和112-220中的一种或多种，或片段的抗炎变体，或抗炎片段和变体的混合物。
在一个实施方案中，组合物包含SEQUENCE ID NO 108、109和144中的至少一种、两种或三种。
在一个实施方案中，本发明的组合物富含分子量小于10KD的肽。在一个实施方案中，组合物几乎没有(depleted of)细胞碎片。
在一个实施方案中，本发明的组合物是粉末。
在一个实施方案中，本发明包括一组合物，其包含SEQUENCE ID NO:108-109和112-220基本上全部的片段，或片段的抗炎变体，或抗炎片段和变体的混合物。
在一个实施方案中，组合物是可食用的(可食的)。在一个实施方案中，组合物是食物或饮料。在一个实施方案中，组合物是个人护理组合物。在一个实施方案中，组合物是药物组合物。在一个实施方案中，组合物是营养补充剂。在一个实施方案中，组合物是固体。在一个实施方案中，组合物是半固体(即，乳膏、凝胶或洗剂)。在一个实施方案中，组合物是液体。
本发明还涉及一种包含本发明的肽的可食产品。优选地，可食产品是人造的。
本发明还涉及一种包含本发明的肽的组合物的可食产品。优选地，可食产品是人造的。
优选地，可食产品是用于人类或动物(哺乳动物)消费的食品。
在一个实施方案中，人造可食产品是饮料。在一个实施方案中，人造可食产品是焙烤产品。在一个实施方案中，人造可食产品是乳制品。在一个实施方案中，人造可食产品是零食产品。在一个实施方案中，人造可食产品是烘烤挤压食品。在一个实施方案中，人造可食产品是奶粉。在一个实施方案中，人造可食产品是婴儿配方产品。在一个实施方案中，人造可食产品是糖果产品。在一个实施方案中，人造可食产品是酸奶。在一个实施方案中，人造可食产品是酸奶饮料。在一个实施方案中，人造可食产品是冰淇淋产品。在一个实施方案中，人造可食产品是冷冻食品。在一个实施方案中，人造可食产品是早餐谷物。在一个实施方案中，人造可食产品是面包。在一个实施方案中，人造可食产品是风味乳饮料。在一个实施方案中，人造可食产品是糖果条。在一个实施方案中，人造可食产品是茶或茶产品。在一个实施方案中，人造可食产品是基础挤压(based extruded)零食产品。在一个实施方案中，人造可食产品是油炸零食产品。在一个实施方案中，人造可食产品是营养补充剂。在一个实施方案中，人造可食产品是运动营养产品。在一个实施方案中，人造可食产品是婴儿食品。在一个实施方案中，人造可食产品是用于免疫功能低下个体的特制食品。在一个实施方案中，人造可食产品是用于老年病人的食品。
本发明还涉及一种包含本发明的肽的人造个人护理组合物。
本发明还涉及一种包含本发明的肽的组合物的人造个人护理组合物。
在一个实施方案中，个人护理组合物是护肤产品。在一个实施方案中，个人护理组合物是护发产品。在一个实施方案中，个人护理组合物是牙膏产品。在一个实施方案中，个人护理组合物是香料产品。在一个实施方案中，个人护理组合物是除臭产品。在一个实施方案中，个人护理组合物是止汗剂产品。在一个实施方案中，个人护理组合物是肥皂。在一个实施方案中，个人护理组合物是液体肥皂。在一个实施方案中，个人护理组合物是乳膏。在一个实施方案中，个人护理组合物是洗剂。在一个实施方案中，个人护理组合物是凝胶。在一个实施方案中，个人护理组合物是粉末。
本发明还涉及一种用于治疗或预防哺乳动物炎症的本发明的肽。
本发明还涉及一种用于治疗或预防哺乳动物炎症的本发明的肽的组合物。
本发明还涉及一种用于治疗或预防哺乳动物炎性紊乱(inflammatory disorder)的本发明的肽。
本发明还涉及一种用于治疗或预防哺乳动物炎性紊乱的本发明的肽的组合物。
在一个实施方案中，炎症是症状性炎症。
在一个实施方案中，炎性紊乱是关节的炎性紊乱。在一个实施方案中，炎性疾病是心血管系统的炎性紊乱。在一个实施方案中，炎性紊乱是自身免疫性疾病。在一个实施方案中，炎性紊乱是肺和气道炎性疾病。在一个实施方案中，炎性紊乱是肠道炎性紊乱。在一个实施方案中，炎性紊乱是皮炎。在一个实施方案中，炎性紊乱是寻常痤疮。在一个实施方案中，炎性紊乱是银屑病。在一个实施方案中，炎性紊乱是类风湿性关节炎。在一个实施方案中，炎性紊乱是心血管疾病。在一个实施方案中，炎性紊乱是动脉粥样硬化。在一个实施方案中，炎性紊乱是I型糖尿病。在一个实施方案中，炎性紊乱是格雷夫斯病(Gravesdisease)。在一个实施方案中，炎性紊乱是格林-巴利病(Guillain-Barre disease)。在一个实施方案中，炎性紊乱是狼疮。在一个实施方案中，炎性紊乱是牛皮癣性关节炎。在一个实施方案中，炎性紊乱是溃疡性结肠炎。在一个实施方案中，炎性紊乱是哮喘。在一个实施方案中，炎性紊乱是囊肿性纤维化。在一个实施方案中，炎性紊乱是COPD。在一个实施方案中，炎性紊乱是肺气肿。在一个实施方案中，炎性紊乱是急性呼吸窘迫综合征。在一个实施方案中，炎性紊乱是结肠炎。在一个实施方案中，炎性紊乱是炎性肠病。
本发明还涉及一种用于治疗或预防哺乳动物的疼痛的本发明的肽。
本发明还涉及一种用于治疗或预防哺乳动物的疼痛的本发明的肽的组合物。
本发明还涉及一种用于治疗或预防哺乳动物的代谢紊乱的本发明的肽。
本发明还涉及一种用于治疗或预防哺乳动物的代谢紊乱的本发明的肽的组合物。
在一个实施方案中，代谢紊乱是前期糖尿病(pre-diabetes)。在一个实施方案中，代谢紊乱是糖尿病。在一个实施方案中，代谢紊乱是1型糖尿病。在一个实施方案中，代谢紊乱是2型糖尿病。在一个实施方案中，代谢紊乱是代谢综合征。在一个实施方案中，代谢紊乱是肥胖。在一个实施方案中，代谢紊乱是糖尿病性血脂异常。在一个实施方案中，代谢紊乱是高脂血症。在一个实施方案中，代谢紊乱是高血压。在一个实施方案中，代谢紊乱是高甘油三酯血症。在一个实施方案中，代谢紊乱是高脂肪酸血症(hyperfattyacidemia)。在一个实施方案中，代谢紊乱是高胆固醇血症。在一个实施方案中，代谢紊乱是高胰岛素血症。在一个实施方案中，代谢紊乱是MODY。
本发明还涉及一种用于维持或恢复哺乳动物的肠道健康的本发明的肽。
本发明还涉及一种用于维持或恢复哺乳动物的肠道健康的本发明的肽的组合物。
本发明还涉及一种用于维持或恢复哺乳动物的肌肉健康(例如，瘦肉组织量)的本发明的肽。
本发明还涉及一种用于维持或恢复哺乳动物的肌肉健康(例如，瘦肉组织量)的本发明的肽的组合物。
本发明还涉及一种包含本发明的肽以及药学上可接受的载体的药物组合物。
本发明还涉及一种药物组合物，其包含本发明的肽的组合物以及药学上可接受的载体。
这样的肽可用于个人护理、补充剂、食品和药物产品以治疗和维持整个身体的健康水平的炎症。本发明满足了对食源性特异性肽和肽组合物的巨大需求，该食源性特异性肽和肽组合物以能够被身体处理而不会完全阻断免疫反应和引起自身免疫问题及其它不希望的副作用的方式减少炎症。本发明最终帮助了20亿炎症患者。
本发明还涉及一种可食产品，例如包含本发明的组合物的食品，例如乳制品或非乳制品、固体食品或饮料、食品添加剂或补充剂。乳制品可以是牛奶、奶酪或酸奶。在一个实施方案中，食品是零食条。食品可以包含任何量的本发明组合物，例如0.1％至30％(w/w)。
本发明的肽以化妆或药学上有效的浓度用于本发明的局部用化妆或药物组合物以达到期望的效果；相对于组合物的总重量，优选形式为0.00000001％(以重量计)至20％(以重量计)；优选为0.000001％(以重量计)至15％(以重量计)，更优选为0.0001％(以重量计)至10％(以重量计)，且甚至更优选为0.0001％(以重量计)至5％(以重量计)。理想地，优选以组合物的约0.00001％w/w至约0.5％w/w[0.1至5000ppm]，且更优选为0.00005w/w至约0.05w/w[0.5至500ppm]，且最优选为约0.0001w/w至约0.01w/w的[1至100ppm]使用本发明的肽。理想地，优选以组合物的约0.0001％w/w至约0.004％w/w使用本发明的肽。
对于本发明的肽的组合物，典型的每日剂量可以是0.2g至100g。
用于食品和食品补充剂(即，可食组合物)的本发明的组合物的剂量将广泛地在0.2-100g/天的范围内。在一个实施方案中，每日剂量为1-10g/天，理想地为约3-8g/天。在一个实施方案中，每日剂量为10-20g/天。在一个实施方案中，每日剂量为20-30g/天。在一个实施方案中，每日剂量为30-40g/天。在一个实施方案中，每日剂量为10-100g/天。在一个实施方案中，每日剂量为约5g/天，理想地为约3-8g/天。在一个实施方案中，剂量为2-1000mg/天/kg体重。在一个实施方案中，剂量为10-500mg/天/kg体重。在一个实施方案中，剂量为10-100mg/天/kg体重。在一个实施方案中，剂量为30-70mg/天/kg体重。用于食品补充剂的本发明的肽的剂量可以是每天或每剂0.00001mg-0.01mg。
食品可以是用于特定医疗目的的食品(FSMP)，其被定义为特殊配制、加工并旨在对在医疗监督下接受治疗的个体的疾病、紊乱或医疗状况进行饮食管理的食品。这些食品旨在用于那些正常食物无法满足其营养需求的人的全部或部分进食(exclusive orpartial feeding)。剂量可以是每天50-500g，这取决于患者的年龄和状况。当作为用于特殊医疗目的的食品或医疗食品施用时，每日剂量可以是每天50-500g。
本发明的肽和组合物还可用于炎症的非治疗性处理。炎症的非治疗性处理的实例包括用于减轻正常的非病理性炎症，例如运动后的肌肉和关节内的炎症。
本发明还提供了包含本发明的肽的局部组合物。应该理解，局部组合物可以包含多种肽、片段和/或变体。在一个实施方案中，局部组合物包含基本上所有的肽。在一个实施方案中，局部组合物包含基本上所有的变体。本发明的局部组合物可以存在于制剂中，所述制剂选自包括乳膏、多重乳液(multiple emulsions)、无水组合物、水分散液、油、乳、香膏、泡沫、洗剂、凝胶、凝胶乳霜、水醇溶液、水乙醇酸溶液、化妆品、个人护理产品、水凝胶、擦剂、血清(sera)、肥皂、扑粉、糊剂、半固体制剂、擦剂、血清(serum)、洗发水、护发素、软膏、任何冲洗剂、滑石、摩丝、粉末剂、喷雾剂、气雾剂、溶液、混悬剂、乳剂、糖浆、酏剂、多糖膜、贴剂、凝胶贴剂、绷带、粘合剂体系、油包水乳剂、水包油乳剂和硅酮乳剂的组。
在本发明的一个实施方案中，乳剂含有脂质或油。乳剂可以是但不限于水包油、油包水、水包油包水和硅酮包水包油(oil-in-water-in-silcone)乳剂。乳剂可以含有保湿剂。乳剂可以含有消泡剂如硅酮。乳剂可以具有任何合适的粘度。乳剂还可含有乳化剂和/或消泡剂。制备乳剂的方法是本领域技术人员已知的。
可将本发明的局部组合物掺入用于施用的医疗器械中。这种器械可以包括但不限于织物、贴片、绷带、计量器、袜子、紧身衣、内衣、敷料、手套、面罩、粘合贴剂、非粘合贴剂、封闭贴剂和微电贴剂或合适的粘合体系。在这样的实施方案中，器械与角质层如皮肤直接接触，从而释放本发明的肽。应该理解，可以本文详述的任何合适的形式掺入局部组合物。例如，本发明的局部组合物或肽可掺入器械中或存在于器械表面上，或者可以是乳膏、凝胶或蜡制剂或本文定义的任何合适的制剂并且掺入到器械中或器械表面上。器械可以适合于粘附或附着到皮肤上。
在一个实施方案中，器械适于释放恒定量的本发明的组合物或肽。应当理解，持续释放系统中所含的组合物的量取决于例如组合物将在何处施用、本发明组合物的释放的动力学和持续时间，以及待治疗和/或待护理的状况、紊乱和/或疾病的性质。器械可以使得组合物由于身体水分、皮肤的pH或体温而通过器械的生物降解，或者通过器械与身体之间的摩擦，而被释放。
在本发明的一个实施方案中，局部组合物还可包含至少一种化妆或药学上可接受的赋形剂。赋形剂可以与功能成分或添加剂互换使用。应该理解，虽然本发明的局部组合物可以单独施用，但它们通常与化妆或药物赋形剂混合施用。化妆或药学上可接受的赋形剂是本领域公知的，并且是可以使用的任何已知的赋形剂，只要其适合于局部施用并且是皮肤病学可接受的而没有不适当毒性(undue toxicity)、不相容性和/或过敏反应。
优选地，包含的任何赋形剂以痕量存在。包含的赋形剂的量将取决于许多因素，包括所用的赋形剂的类型、赋形剂的性质、局部组合物的(多种)组分、局部组合物中的活性成分或肽的量和/或局部组合物的预期用途。任何赋形剂的性质和量不应不可接受地改变本发明的肽的益处。
在本发明的一个实施方案中，赋形剂可以是合适的稀释剂、载体、粘合剂、润滑剂、悬浮剂、包衣剂、防腐剂、稳定剂、染料、载体、增溶剂、碱、润肤剂、乳化剂、香气剂(fragrance)、保湿剂和/或表面活性剂。
合适的稀释剂的实例包括但不限于US2014120131或US2004132667中公开的任何稀释剂。实例包括乙醇、甘油和水。
合适的载体的实例包括但不限于乳糖、淀粉、葡萄糖、甲基纤维素、硬脂酸镁、甘露醇、山梨醇和US2014120131或US2004132667中公开的任何合适的载体。
合适的粘合剂的实例包括但不限于淀粉、明胶、天然糖如葡萄糖、无水乳糖、自由流动乳糖、β-乳糖、玉米甜味剂、天然和合成树胶如阿拉伯胶、黄蓍胶或海藻酸钠、羧甲基纤维素和聚乙二醇以及US2014120131或US2004132667中公开的任何合适的粘合剂。
合适的润滑剂的实例包括但不限于油酸钠、硬脂酸钠、硬脂酸镁、苯甲酸钠、乙酸钠和氯化钠以及US2014120131或US2004132667中公开的任何合适的润滑剂。
载体可以是本领域已知的任何合适的载体或在US2014120131或US2004132667中公开的任何合适的载体。在一些实施方案中，载体可以包括但不限于液体如水、油或表面活性剂，包括石油、动物、植物或合成来源的那些，聚合物，油如花生油、矿物油、蓖麻油、大豆油，醇，聚山梨醇酯，山梨醇酯(sorbitan ester)，醚硫酸盐，硫酸盐，甜菜碱，糖苷，麦芽糖苷，脂肪醇，壬苯醇醚，泊洛沙姆，聚氧乙烯，聚乙二醇，右旋糖，甘油或洋地黄皂苷。应该理解，载体将是皮肤病学可接受的。优选的载体包含乳剂，例如水包油、油包水、水包油包水和硅酮包水包油(oil-in-water-in-silicone)乳剂。乳剂还可含有乳化剂和/或消泡剂。
在本发明的一个实施方案中，局部组合物还可包含一种或多种附加成分。本发明的局部组合物可与一种或多种其它附加试剂连续地、同时地或相继地施用。这种附加成分可以是包含在局部组合物中有益处或者取决于局部组合物的预期用途有益处的那些。附加成分可以是活性的或功能性的或两者皆有。
这种附加成分的实例包括但不限于以下的一种或多种：清洁剂、调节剂、防晒剂、颜料、保湿剂、增稠试剂、胶凝剂、精油、收敛剂、颜料、抗结块剂、消泡剂、粘合剂、添加剂、缓冲剂、络合剂(chelating agent)、外用止痛剂、成膜剂或材料、填充剂、聚合物、乳浊剂、pH调节剂、推进剂、还原剂、螯合剂(sequestrants)、皮肤增白剂和提亮剂、皮肤调理剂、芦荟(aloe vera)、修复剂、舒缓剂、平滑剂、泛酸、处理剂、增稠剂、维生素、着色剂、药物、防腐剂、消泡剂、缓冲剂、收敛剂、聚合物、pH调节剂、除臭剂或任何其它皮肤病学可接受的载体或表面活性剂。
应该理解，列出的附加成分可以提供多于一种益处。本文给出的分类仅仅是为了清楚和方便，并非旨在将附加成分局限于列出的特定应用或类别。
任何附加成分应该适合施用于皮肤而没有不适当的毒性、不相容性和/或过敏反应。
在一些实施方案中，附加成分具有葡萄糖转运活性或者有助于葡萄糖转运活性。在一些实施方案中，附加成分具有抗炎活性或有助于抗炎活性。在一些实施方案中，附加成分具有抗老化活性或有助于抗老化活性。在一些实施方案中，附加成分用于角质层健康和/或发育、皮肤健康和/或发育，和/或肌肉健康、恢复和/或发育。活性剂可以是药理学增强剂。这样的活性剂是已知的并且在市场上可得到。在这样的情况下，本发明的局部组合物可与一种或多种其它活性剂连续地、同时地或相继地施用。
在一些实施方案中，附加成分可以是法尼醇([2E,6E],-3,7,11,-三甲基-2,6,10,十二碳三烯-1-醇)、植烷三醇(3,7,11,15,四甲基十六烷-1,2,3,-三醇)、脱屑活性物、酶、酶抑制剂、酶激活剂、植物提取物和海洋提取物、抗痤疮活性物、抗皱纹或抗萎缩活性物、抗氧化剂/自由基清除剂、络合剂、类黄酮、抗炎剂、消脂剂(anti-cellulite agent)、局部麻醉剂、晒黑活性物、皮肤提亮剂、皮肤修复剂、甜没药醇、抗微生物或抗真菌活性物、防晒活性物、颗粒材料、调理剂、结构化剂、增稠剂。
脱屑活性物可以是增强皮肤外观或皮肤纹理的任何合适的试剂，并且如US2014120131或US2004132667中所公开的。
抗痤疮活性物的实例如US2014120131或US2004132667中所公开的，并包括间苯二酚、水杨酸、红霉素、锌、硫、过氧化苯甲酰。
增稠剂的实例如US2014120131或US2004132667中所公开的，并且包括羧酸聚合物、交联聚丙烯酸酯聚合物、聚丙烯酰胺聚合物、多糖。
调理剂的实例如US2014120131或US2004132667中所公开的，并且包括保湿剂、润肤剂或皮肤调理剂。
结构化剂的实例如US2014120131或US2004132667中所公开的，并包括为组合物提供流变特性并有助于组合物的稳定性的任何试剂。
可以使用任何合适的抗微生物或抗真菌活性物，并且实例如US2014120131或US2004132667中所公开的。这些活性物能够破坏微生物、防止微生物的生长或作用。实例包括但不限于β-内酰胺药物、喹诺酮药物、四环素、红霉素、硫酸链霉素、水杨酸、过氧化苯甲酰。
颗粒材料的实例包括金属氧化物。消脂剂的实例包括黄嘌呤剂。晒黑活性物的实例包括1,3-二羟基-2-丙酮和US2014120131或US2004132667中公开的那些。局部麻醉剂的实例包括苯佐卡因、利多卡因和布比卡因以及US2014120131或US2004132667中公开的那些。
皮肤提亮剂的实例包括本领域已知的任何试剂如曲酸、抗坏血酸和US2014120131或US2004132667中公开的那些。
防晒活性物的实例包括任何合适的有机或无机防晒活性物。实例包括金属氧化物、2-乙基己基-对-甲氧基肉桂酸酯和US2014120131或US2004132667中公开的那些。
皮肤修复剂的实例包括如US2014120131或US2004132667中公开的泛酸。
抗炎剂的实例包括增强皮肤外观、肤色或颜色的任何试剂，并且包括但不限于皮质类固醇、氢化可的松、非非甾体剂如布洛芬和阿司匹林，以及US2014120131或US2004132667中公开的那些。
类黄酮的实例包括黄烷酮、甲氧基黄酮、未取代的查耳酮及其混合物以及US2014120131或US2004132667中公开的那些。
酶的实例包括脂肪酶、蛋白酶、过氧化氢酶、超氧化物歧化酶、淀粉酶、过氧化物酶、葡糖醛酸酶、神经酰胺酶、透明质酸酶。酶抑制剂的实例包括胰蛋白酶抑制剂、BowmannBirk抑制剂、糜蛋白酶抑制剂、植物提取物、类黄酮、槲皮素查耳酮以及US2014120131或US2004132667中公开的那些及其混合物。酶激活剂的实例包括辅酶A、Q10(泛醌)、甘草甜素、小檗碱、白杨素和US2014120131或US2004132667中公开的那些及其混合物。
抗皱纹或抗萎缩活性物的实例包括含硫的D和L氨基酸，特别是N-酰基衍生物如N-乙酰基-L-半胱氨酸、羟基酸、植酸、硫辛酸、溶血磷脂酸、皮肤剥离剂、维生素B3、类维生素A和US2014120131或US2004132667中公开的那些及其混合物。
抗氧化剂/自由基清除剂可以是用于提供防紫外线辐射或其它可能引起皮肤损伤的环境试剂的任何试剂，例如US2014120131或US2004132667中公开的那些。抗氧化剂/自由基清除剂的实例包括抗坏血酸，其盐和衍生物(维生素C)、生育酚及其盐和衍生物(维生素E)、丁基化羟基苯甲酸及其盐、过氧化物、没食子酸和烷基酯、山梨酸、硫辛酸、胺、吡酮酸甜菜碱(lycine pidolate)、精氨酸氧脯氨酸(pilolate)、去甲二氢愈创木酸、生物类黄酮、姜黄素、赖氨酸、蛋氨酸、脯氨酸、超氧化物歧化酶、水飞蓟素、茶提取物及其混合物。
络合剂的实例包括EDTA、NTA、异羟肟酸(hydoxamic acid)、植酸、乳铁蛋白和US2014120131或US2004132667中公开的那些及其混合物。络合剂是指能够通过形成配合物来去除金属离子使得金属离子不能参与化学反应或催化化学反应的试剂。络合剂可用于防止紫外线辐射或可能导致皮肤损伤的其它环境因素。
应该理解，可以添加多种附加成分。附加成分的量可为组合物的重量的约0.001％至约50％，优选为约0.01％至约20％，优选为约0.1％至约10％，约0.5％至约10％，约1％至约5％，优选为组合物的重量的2％。包括的附加成分的量将取决于许多因素，包括使用的附加成分的类型、附加成分的性质、局部组合物的(多种)成分、局部组合物中的活性物或肽的量和/或局部组合物的预期用途。任何附加成分的性质和量不应不可接受地改变本发明的肽的益处。
局部组合物可以是无酒精的。
在本发明的一些实施方案中，除了本发明的肽(还称为组合物的活性物)之外，组合物还包含一种或多种附加活性剂。此外或可替代地，组合物可以与一种或多种其它附加活性剂一起施用。典型的所述附加活性剂仅以痕量存在。在一些实施方案中，组合物中可能不存在附加活性剂。包含的附加活性剂的量将取决于许多因素，包括所用的附加活性剂的类型、附加活性剂的性质、局部组合物的(多种)成分、局部组合物中的活性物或肽的量和/或局部组合物的预期用途。任何附加活性剂的性质和量不应该不可接受地改变本发明的肽的益处。
应该理解，在一种产品中被认为是“活性”成分的成分可能是另一种产品中的“功能”或“赋形剂”成分，反之亦然。还应理解的是，一些成分发挥作为活性成分和作为功能成分或赋形剂成分的双重作用。
附加活性剂的实例包括葡萄糖转运促进药物、皮肤补充剂、皮肤治疗和/或护理剂、抗炎剂、抗老化剂、细胞生长促进剂和药理学增强剂。这些试剂是本领域熟知的，并且可以理解，可以使用任何合适的附加活性剂。用于治疗和/或护理皮肤的附加活性剂可包括胶原蛋白合成剂、类维生素A、去角质剂、消脂剂、弹性蛋白酶抑制剂、黑素合成刺激或抑制剂、自晒黑剂、抗老化剂、抗微生物剂、抗真菌剂、抑真菌剂、杀菌剂和修复剂。活性剂还包括抗炎剂。
任何附加活性剂应该适合施用于皮肤而没有不适当毒性、不相容性和/或过敏反应。
应当理解，本文给出的分类仅仅是为了清楚和方便，并非旨在将附加成分、赋形剂或活性物局限于列出的特定应用或类别。
在特别优选的实施方案中，本发明的方法和用途包括将本发明的肽或组合物与一种或多种其它活性剂(例如，市场上可获得的现有生长促进药或药理学增强剂)组合施用。在这种情况下，本发明的化合物可与一种或多种其它活性剂连续地、同时地或相继地施用。
本发明的效果通过将本文所述的本发明的局部组合物局部应用或施用至需要治疗或护理的人、动物或患者来实现。局部递送优选意指递送至角质层如皮肤、头发和/或指甲，但还可以意指递送至衬有上皮细胞的体腔，例如肺或气道、胃肠道、颊腔。效果可以局限于皮肤表面或可以在皮肤内或两者的组合。
以化妆(cosmetically)或药学上有效的量施用本发明的局部组合物。换言之，以无毒但足以提供期望效果的量。应该理解，本领域技术人员将能够确定施用本发明的局部组合物的合适剂量，而无需过多的实验。可替代地，医师将根据特定状况、待治疗或护理的疾病或病症以及个体的年龄、体重和/或健康状况来确定最适合于患者的实际剂量。这将取决于多种因素，包括所采用的具体化合物的活性、该化合物的代谢稳定性和作用时间长度、年龄、体重、一般健康状况、性别、饮食、施用方式和时间、排泄速率、药物组合、特定病况的严重程度以及正在接受治疗的个体。当然，可以有更高或更低剂量范围是合适的个别情况，并且这也在本发明的范围内。例如，可以0.01至50mg/kg体重，例如0.1至30mg/kg，更优选为0.1至20mg/kg体重，更优选为0.1至10mg/kg体重，优选为0.1至5mg/kg体重的剂量施用组合物。在一个示例性实施方案中，10至300mg/天或更优选为10至150mg/天的一个或多个剂量将施用给患者。量和频率最适合于目的。根据每个受试者的需要，应用或施用的频率可以变化很大，并且推荐的应用或施用范围从每月一次到每天十次，优选为每周一次到每天四次，更优选为从每周三次到每天三次，甚至更优选为每天一次或两次。
在优选的实施方案中，提供了局部组合物的重复使用。
可通过但不限于摩擦或按摩到待治疗或护理的角质组织、皮肤或身体区域中应用局部组合物。在一些实施方案中，组合物留在身体的区域上或不从身体的区域去除。在其它实施方案中，在一段时间之后，例如但不限于约2分钟至60分钟、约5分钟至约30分钟，优选为约10分钟至约20分钟之后去除组合物。应用后可立即去除组合物。在本发明的一些实施方案中，可通过获得本发明的组合物和/或肽的更大渗透的方法而将本发明的组合物应用于待治疗的区域，例如但不限于离子电渗法、超声波导入、电穿孔、微电贴片、机械压力、渗透压梯度、闭塞性治疗、借助于压力的微注射或无针注射如通过氧分压注射，或其任何组合。
本发明的肽以化妆或药学上有效的浓度用于本发明的局部用化妆或药物组合物以达到期望的效果；相对于组合物的总重量，优选形式为0.00000001％(以重量计)至20％(以重量计)；优选为0.000001％(以重量计)至15％(以重量计)，更优选为0.0001％(以重量计)至10％(以重量计)，且甚至更优选为0.0001％(以重量计)至5％(以重量计)。
在本发明的一些实施方案中，组合物可以经由以下的任一来递送：脂质体、混合脂质体、油质体、泡囊(niosome)、醇质体、微胶囊、胶囊、大胶囊、纳米胶囊、纳米结构化脂质载体、海绵、环糊精、囊泡、胶束、表面活性剂的混合胶束、表面活性剂-磷脂混合胶束、微球、球、脂质球、颗粒、纳米球、纳米颗粒、微粒、固体纳米颗粒以及微乳液包括具有反胶束的内部结构的油包水微乳液和纳米乳液微球、微颗粒。
多种方法可用于制备脂质体。参见例如，Szoka等人，Ann.Rev.Biophys.Bioeng.9:467(1980)，美国专利号4,186,183、4,217,344、4,235,871、4,261,975、4,485,054、4,501,728、4,774,085、4,837,028、4,235,871、4,261,975、4,485,054、4,501,728、4,774,085、4,837,028、4,946,787、PCT公开号WO 91/17424，Deamer&Bangham、Biochim.Biophys.Acta443:629-634(1976)；Fraley,等人，PNAS 76:3348-3352(1979)；Hope等人，Biochim.Biophys.Acta 812:55-65(1985)；Mayer等人，Biochim.Biophys.Acta 858:161-168(1986)；Williams等人，PNAS 85:242-246(1988)；Liposomes(Ostro(编辑),1983,第1章)；Hope等人，Chem.Phys.Lip.40:89(1986)；Gregoriadis,Liposome Technology(1984)and Lasic,Liposomes:from Physics to Applications(1993))。合适的方法包括例如，超声处理、挤出、高压/均质化、微流化、洗涤剂透析、钙诱导的小脂质体载体的融合和醚融合方法，全部都是本领域熟知的。
这些递送系统可以适合于实现本发明的化合物和/或肽的更大渗透。这可以改善药代动力学和药效学性质。递送系统可以是持续释放系统，其中本发明的化合物或肽在一段时间内逐渐释放并且优选地在一段时间内具有恒定的释放速率。通过本领域已知的方法制备递送系统。包含在持续释放系统中的肽的量将取决于组合物将被递送到何处和释放的持续时间以及待治疗或护理的状况、疾病和/或紊乱的类型。
本发明的局部组合物可以在人类或兽医学中供人类或动物使用。
本发明的局部组合物可以用于药物、个人护理和/或化妆用途。
组合物可用于治疗或护理皮肤的任何疾病、紊乱或状况，包括但不限于银屑病、皮炎、过敏性皮炎、湿疹、海绵层水肿、水肿、皮肤癌、溃疡、痤疮、疤痕、蜂窝织炎、弹性组织变性、角化病、红斑痤疮、静脉曲张、炎性疾病。
局部组合物可用于治疗或护理可见的老化迹象，包括但不限于皱纹、妊娠纹和黑眼圈、干燥、细纹、老年斑、红色斑点、皮肤下垂以及由日晒引起的状况包括晒伤、应激、污染和/饮食。局部组合物也可以用于延缓、减缓或抑制皮肤或老化的发生。可通过医疗器械如本文所述的石膏或贴剂施用组合物。
局部组合物可用于治疗或护理哺乳动物的伤口。在另一个实施方案中，局部组合物用于治疗或预防特征在于受损的上皮细胞或组织，和/或受损的真皮或上皮细胞或组织的疾病或状况。疾病可能是但不限于癌症和创伤。
局部组合物可用于治疗或护理任何肌肉状况，以改善哺乳动物的肌肉状态、通常在锻炼之后促进肌肉的恢复、维持或恢复哺乳动物的肌肉健康(例如，瘦肉组织量)、增强体能表现、治疗或预防特征在于嗜睡或低能量水平的疾病或状况。
局部组合物可用于促进组织生长、促进上皮组织生长、促进皮肤生长、促进器官生长、促进生物体生长。皮肤可以具有正常病理和/或异常病理。
局部组合物也可以用于治疗或护理任何炎性紊乱。
本发明的其它方面涉及一种药物组合物，其包含与一种或多种的药学上可接受的稀释剂、赋形剂或载体混合的本发明的肽或本发明的肽的组合物。尽管本发明的肽和组合物可以单独施用，但它们通常与药物载体、赋形剂或稀释剂混合施用，特别是对于人类治疗。药物组合物可以在人类或兽医学中供人类或动物使用。用于本文所述的各种不同形式的药物组合物的这种合适的赋形剂的实例可在AWade和PJ Weller编辑的“Handbook ofPharmaceutical Excipients”,第2版,(1994)中找到。特别地，用于局部递送的制剂在David Osborne和Antonio Aman,Taylor&Francis编辑的Topical drug deliveryformulations(局部药物递送制剂)中进行了描述，其全部内容通过引用并入本文。用于治疗用途的可接受的载体或稀释剂是制药领域熟知的，并且在例如，Remington'sPharmaceutical Sciences,Mack Publishing Co.(A.R.Gennaro编辑，1985)中进行了描述。合适的载体的实例包括乳糖、淀粉、葡萄糖、甲基纤维素、硬脂酸镁、甘露醇、山梨醇等。合适的稀释剂的实例包括乙醇、甘油和水。药物载体、赋形剂或稀释剂的选择可以根据预期的施用途径和标准药学实践进行选择。药物组合物可以包含作为载体、赋形剂或稀释剂的，或除载体、赋形剂或稀释剂之外的，任何合适的粘合剂、润滑剂、悬浮剂、包衣剂、增溶剂。合适的粘合剂的实例包括淀粉、明胶、天然糖如葡萄糖、无水乳糖、自由流动乳糖、β-乳糖、玉米甜味剂、天然和合成树胶如阿拉伯胶、黄蓍胶或海藻酸钠、羧甲基纤维素和聚乙二醇。合适的润滑剂的实例包括油酸钠、硬脂酸钠、硬脂酸镁、苯甲酸钠、乙酸钠、氯化钠等。可以在药物组合物中提供防腐剂、稳定剂、染料和甚至调味剂。防腐剂的实例包括苯甲酸钠、山梨酸和对羟基苯甲酸的酯。还可以使用抗氧化剂和悬浮剂。
本发明的肽或组合物可适用于局部、口服、直肠、肠胃外、肌内、腹膜内、动脉内、支气管内、皮下、皮内、静脉内、鼻、阴道、颊或舌下施用途径。对于口服给药，特殊用途由压缩片剂、丸剂、片剂、凝胶剂、滴剂和胶囊剂组成。优选地，这些组合物每剂含有1-250mg，且更优选为10-100mg的活性成分。其它施用形式包括可静脉内、动脉内、皮下、皮内、腹膜内或肌内注射的溶液剂或乳剂，并且由无菌或可灭菌的溶液制备。本发明的药物组合物也可以是栓剂、阴道环、子宫托、悬浮剂、乳剂、洗剂、软膏剂、乳膏剂、凝胶剂、喷雾剂、溶液剂或扑粉剂的形式。本发明的组合物可以配制用于局部递送。局部递送通常意指递送至皮肤，但还可以意指递送至衬有上皮细胞的体腔，例如肺或气道、胃肠道、颊腔。特别地，用于局部递送的制剂在David Osborne和Antonio Aman,Taylor&Francis编辑的Topical drug deliveryformulations(局部药物递送制剂)中进行了描述，其全部内容通过引用并入本文。用于递送到气道的组合物或制剂在O'Riordan等人的(Respir Care,2002,Nov.47)、EP2050437、WO2005023290、US2010098660和US20070053845中进行了描述。用于将活性剂递送至回肠特别是近端回肠的组合物和制剂包括微粒和微胶囊，其中活性剂被包封在由聚合物或乳蛋白形成的保护基质内，该保护基质耐酸但易于溶解在回肠的更碱性的环境中。在EP1072600.2和EP13171757.1中描述了这种递送系统的实例。经皮给药的替代方法是通过使用皮肤贴剂。例如，可将活性成分掺入到由聚乙二醇或液体石蜡的含水乳液组成的乳膏中。还可以将活性成分以1至10％重量的浓度掺入到由白蜡或白软石蜡基质以及可能需要的稳定剂和防腐剂组成的软膏剂中。
可注射形式每剂可包含10-1000mg，优选为10-250mg的活性成分。
可以单位剂型(unit dosage)形式，即以含有单位剂量或多个或亚单位的单位剂量的分离部分(discrete portion)的形式配制组合物。
本领域普通技术人员可以容易地确定待施用给主体的本发明组合物之一的合适剂量，而无需过多的实验。通常，医生将确定最适合于个体患者的实际剂量，并且这将取决于多种因素，包括所使用的具体化合物的活性、该化合物的代谢稳定性和作用时间长度、年龄、体重、一般健康状况、性别、饮食、施用方式和时间、排泄速率、药物组合、特定状况的严重程度以及正在接受治疗的个体。本文公开的剂量是平均情况的示例。当然可以有个别情况，其中更高或更低的剂量范围是合适的，并且这些也在本发明的范围之内。根据需要，可以0.01至30mg/kg体重，例如0.1至10mg/kg，更优选为0.1至1mg/kg体重的剂量施用试剂。在一个示例性实施方案中，为了治疗炎性疾病，10至300毫克/天或更优选为10至150毫克/天的一个或多个剂量将施用给患者。
在特别优选的实施方案中，本发明的方法和用途包括将本发明的肽或组合物与一种或多种其它活性剂(例如，市场上可获得的现有抗炎药或药理学增强剂)组合施用。在这种情况下，本发明的组合物可与一种或多种其它活性剂连续地、同时地或相继地施用。
在本发明的一个实施方案中，本发明的肽可以以包含所述肽的缀合物的形式施用，并且可以任选地包含连接子和配偶体分子，例如蛋白质如旨在增加体内缀合物的半衰期的抗体分子。在一个实施方案中，所述肽可被修饰以用一个或多个氨基酸替换，其中氨基酸用于连接配偶体分子。例如，为了缀合配偶体分子如PEG分子的目的，可以用赖氨酸残基替换氨基酸。
定义
对于所有目的，本文提到的所有出版物、专利、专利申请和其它参考文献都通过引用全部并入本文，如同每个单独的出版物、专利或专利申请都被具体和单独地指示以通过引用并入并且其内容被完整引用一样。
在本文中使用的情况下，除非另外明确指出，否则以下术语除了在本领域可能具有的任何更宽(或更窄)的含义之外，还旨在具有以下含义：
除非上下文另有要求，否则在本文中单数的使用应理解为包括复数，且反之亦然。关于实体使用的术语“一(a)”或“一(an)”应被理解为是指一个或多个该实体。因此，术语“一(a)”(或“一(an)”)、“一个或多个”和“至少一个”在本文中可互换使用。
如本文所用，术语“包括(comprise)”或其变型如“包括(comprises)”或“包括(comprising)”应被理解为指示包括任何引述的整体(integer)(例如，特征、要素、特性、性质、方法/过程步骤或限制)或整体组(例如，特征、要素、特性、性质、方法/过程步骤或限制)，但不排除任何其它整体或整体组。因此，如本文所用，术语“包括(comprising)”是包含性的或开放性的，并且不排除另外的未提及的整体或方法/过程步骤。
如本文所用，术语“疾病”用于定义损害生理功能并与特定症状相关的任何异常状况。该术语广泛地用于涵盖其中无论病因性质(或实际上是否确定疾病的病因学基础)的生理功能受损的任何紊乱、疾患、异常、病理、生病、病况或综合征。因此，它涵盖了由感染、创伤、损伤、手术、放射消融、中毒或营养缺陷引起的状况。
如本文所用，术语“治疗(treatment)”或“治疗(treating)”是指干预(例如，向主体施用试剂)，其治愈、改善或减轻疾病的症状或消除其病因(或减轻其病因的影响)(例如，减少溶酶体酶的病理水平的积累)。在这种情况下，该术语与术语“治疗(therapy)”同义使用。
此外，术语“治疗(treatment)”或“治疗(treating)”是指干预(例如，向受试者施用试剂)，其预防或延迟疾病的发作或进展或降低(或根除)其在受治疗人群中的发病率。在这种情况下，术语治疗与术语“预防(prophylaxis)”同义使用。
如本文所用，试剂的有效量或治疗有效量定义了与合理的利益/风险比相称的可以施用于主体而没有过度的毒性、刺激性、过敏反应或其它问题或并发症的量，但其足以提供期望的效果，例如表现为主体状况的永久或暂时改善的治疗或预防。该量因主体不同而变化，其取决于个体的年龄和总体状况、施用方式和其它因素。因此，虽然不可能规定确切的有效量，但本领域技术人员能够使用常规实验和背景常识在任何个体情况下确定适当的“有效”量。在这种情况下的治疗性结果包括根除或减轻症状、减轻疼痛或不适、延长存活、改善活动性和临床改善的其它标志。治疗性结果不一定是完全治愈。
术语“哺乳动物”应该理解为是指高等哺乳动物，特别是人类。然而，该术语还包括非哺乳动物，例如鱼。
本文使用的术语“肽”是指通常通过肽键连接的由多至50个氨基酸单体组成的聚合物。肽的长度可以是3至50个氨基酸。肽的长度可以是4至50个氨基酸。肽的长度可以是5至50个氨基酸。肽的长度可以是7至50个氨基酸。作为本发明和用于本发明的肽(包括其片段和变体)可全部或部分地通过化学合成或通过从核酸表达来产生。例如，可以根据本领域已知的充分确认(well-established)的标准液体或优选为固相肽合成方法容易地制备本发明的肽和用于本发明的肽(参见例如，J.M.Stewart和J.D.Young,Solid Phase PeptideSynthesis,第2版，M.Bodanzsky和A.Bodanzsky中的Pierce Chemical Company,Rockford,Illinois(1984),The Practice of Peptide Synthesis,Springer Verlag,New York(1984))。必要时，本发明中使用的任何肽可以被化学修饰以增加它们的稳定性。经化学修饰的肽或肽类似物包括肽的任何功能化学等价物，其特征在于相对于本发明的实践，其在体内或体外的稳定性和/或功效提高。术语肽类似物还是指如本文所描述的肽的任何氨基酸衍生物。可通过包括但不限于侧链的修饰、在肽合成过程中掺入非天然氨基酸和/或其衍生物和使用交联剂以及在肽或其类似物上施加构象约束的其它方法的程序来制备肽类似物。侧链修饰的实例包括氨基的修饰，例如还原烷基化，通过与醛反应，随后用NaBH4还原；用乙酰亚胺酸甲酯酰胺化；用乙酸酐乙酰化；用氰酸酯对氨基进行氨基甲酰化；用2,4,6-三硝基苯磺酸(TNBS)对氨基进行三硝基苄基化；用琥珀酸酐和四氢邻苯二甲酸酐对氨基进行的烷基化；以及用吡哆醛-5'-磷酸酯对赖氨酸进行吡哆化(pyridoxylation)，随后用NABH4还原。精氨酸残基的胍基可以通过与试剂如2,3-丁二酮、苯甲酰甲醛和乙二醛形成杂环缩合产物来修饰。羧基可以通过经由O-酰基异脲形成的碳二亚胺活化，然后随后的衍生化例如到相应的酰胺来修饰。巯基可以通过(多种)方法来修饰，诸如与碘乙酸或碘乙酰胺的羧甲基化；过甲酸氧化成磺基丙氨酸；与其它硫醇化合物形成混合二硫化物；与马来酰亚胺反应；马来酸酐或其它取代的马来酰亚胺；使用4-氯汞苯甲酸、4-氯汞苯磺酸、氯化苯汞、2-氯汞-4-硝基苯酚和其它汞制剂形成汞衍生物；在碱性pH下用氰酸酯进行的氨基甲酰化。色氨酸残基可通过例如用N-溴琥珀酰亚胺来氧化或用2-羟基-5-硝基苄基溴或磺酰卤来对吲哚环进行烷基化来修饰。酪氨酸残基可以通过用四硝基甲烷来硝化以形成3-硝基酪氨酸衍生物来改变。组氨酸残基的咪唑环的修饰可以通过用碘乙酸衍生物进行烷基化或用焦碳酸二乙酯进行N-乙酯基化来完成。在肽合成期间掺入非天然氨基酸和衍生物的实例包括但不限于使用正亮氨酸、4-氨基丁酸、4-氨基-3-羟基-5-苯基戊酸、6-氨基己酸、叔丁基甘氨酸、正缬氨酸、苯基甘氨酸、鸟氨酸、肌氨酸、4-氨基-3-羟基-6-甲基庚酸、2-噻吩基丙氨酸和/或氨基酸的D-异构体。肽结构修饰包括产生包含由D-氨基酸编码的反向序列的逆反肽(retro-inverso peptide)。
“经修饰肽”：在本发明的一个实施方案中，该肽是经修饰肽。术语经修饰肽与术语肽的衍生物可互换使用。经修饰肽包括已经被一个或多个如本文所定义的基团替换的肽。该修饰可以是任何修饰，其提供具有增加的穿透细胞的能力的本发明的肽和/或组合物。该修饰可以是增加本发明的组合物或肽的半衰期的任何修饰。在一个实施方案中，该基团是保护基。保护基可以是N-末端保护基、C-末端保护基或侧链保护基。该肽可具有这些保护基团中的一个或多个。本领域技术人员知道使氨基酸与这些保护基团反应的合适技术。这些基团可以通过本领域已知的制备方法来添加，例如US2014120141的段落[0104]至[0107]中概述的方法。这些基团可能保留在肽上或可能脱除。保护基可以在合成过程中加入。在本发明的一个实施方案中，肽可以被选自以下的基团取代：一个或多个直链或支链、长链或短链、饱和或不饱和，被羟基、氨基、氨基酰基、硫酸根或硫化物基团取代或未取代，具有1至29个碳原子。N-酰基衍生物包括衍生自乙酸、癸酸、月桂酸、肉豆蔻酸、辛酸、棕榈酸、硬脂酸、山嵛酸、亚油酸、亚麻酸、硫辛酸、油酸、异硬脂酸、反油酸、2-乙基己酸(2-ethylhexaneicacid)、椰子油脂肪酸、牛油脂肪酸、硬化牛油脂肪酸、棕榈仁脂肪酸、羊毛脂脂肪酸或类似的酸。这些可以是取代的或未取代的。当被取代时，它们优选被羟基或含硫基团取代，例如但不限于SO3H、SH或S-S。在本发明的一个实施方案中，肽是R1-X-R2。R1和/或R2基团分别与肽序列的氨基末端(N-末端)和羧基末端(C-末端)结合。在一个实施方案中，肽是R1-X。或者，肽是X-R2。优选地，R1是H、C1-4烷基、乙酰基、苯甲酰基或三氟乙酰基。X是本发明的肽；R2是OH或NH2。在一个实施方案中，R1选自由H、非环取代的或未取代的脂肪族基团、取代的或未取代的脂环族、取代的或未取代的杂环基、取代的或未取代的杂芳基烷基、取代的或未取代的芳基、取代的或未取代的芳烷基、叔丁氧基羰基、9-芴基甲氧基羰基(Fmoc)和R5-CO-形成的基团，其中R5选自由H、非环取代的或未取代的脂肪族基团、取代的或未取代的脂环族、取代的或未取代的芳基、取代的或未取代的芳烷基，取代的或未取代的杂环基和取代的或未取代的杂芳基烷基形成的基团；R2选自由-NR3R4、-OR3和-SR3形成的基团，其中R3和R4独立地选自由H、非环取代的或未取代的脂肪族基团、取代的或未取代的脂环族、取代的或未取代的杂环基、取代的或未取代的杂芳基烷基、取代的或未取代的芳基和取代的或未取代的芳烷基形成的基团；并且条件是R1和R2不是α-氨基酸。根据另一个优选的实施方案，R2为-NR3R4、-OR3或-SR3，其中R3和R4独立地选自由以下形成的基团：H、取代的或未取代的C1-C24烷基、取代的或未取代的C2-C24烯基、叔丁氧基羰基、9-芴基甲氧基羰基(Fmoc)、取代的或未取代的C2-C24炔基、取代的或未取代的C3-C24环烷基、取代的或未取代的C5-C24环烯基、取代的或未取代的C8-C24环炔基、取代的或未取代的C6-C30芳基、取代的或未取代的C7-C24芳烷基、3-10元的取代的或未取代的杂环基环，以及2-24个碳原子和1-3个非碳原子的取代或未取代的杂芳基烷基，其中烷基链具有1-6个碳原子。任选地，R3和R4可以通过饱和或不饱和的碳-碳键键合，与氮原子形成环。更优选地，R2是-NR3R4或-OR3，其中R3和R4独立地选自由以下形成的基团：H、取代的或未取代的C1-C24烷基、取代的或未取代的C2-C24烯基、取代的或未取代的C2-C24炔基、取代的或未取代的C3-C10环烷基、取代的或未取代的C6-C15芳基和3-10元的取代的或未取代的杂环基、具有3至10元的环和1至6个碳原子的烷基链的取代的或未取代的杂芳基烷基。更优选地，R3和R4选自由以下形成的基团：H、甲基、乙基、己基、十二烷基或十六烷基。甚至更优选地，R3是H且R4选自由H、甲基、乙基、己基、十二烷基或十六烷基形成的基团。根据甚至更优选的实施方案，R2选自-OH和-NH2。根据本发明的另一个实施方案，R1选自由H、乙酰基、月桂酰基、肉豆蔻酰基或棕榈酰基形成的基团，且R2为-NR3R4或-OR3，其中R3和R4独立地选自H、甲基、乙基、己基、十二烷基和十六烷基，优选地R2是-OH或-NH2。更优选地，R1是乙酰基或棕榈酰基，并且R2是-NH2。在一个优选的实施方案中，酰基与肽的至少一个氨基酸的N-末端键合。在本发明的一个实施方案中，肽被修饰以包含侧链保护基。侧链保护基可以是包括苄基的基团或基于苄基的基团、基于叔丁基的基团、苄氧基-羰基(Z)基团和烯丙氧基羰基(alloc)保护基中的一种或多种。侧链保护基可以衍生自非手性氨基酸如非手性甘氨酸。非手性氨基酸的使用有助于稳定所得的肽，并且还有利于本发明的简易合成路线。优选地，肽还包含经修饰的C-末端，优选为酰胺化的C-末端。非手性残基可以是α-氨基异丁酸(甲基丙氨酸)。应该理解，所使用的特定侧链保护基将取决于肽的序列和所使用的N-末端保护基的类型。
“缀合物”：在本发明的一个实施方案中，肽缀合、连接或融合至结合配偶体，例如一种或多种聚乙二醇聚合物或其它化合物，如分子量增加化合物或亲脂性基团。分子量增加化合物是将所得缀合物的分子量增加通常10％至90％或20％至50％的任何化合物，并且可具有200至20,000，优选为500至10,000的分子量。分子量增加化合物可以是PEG、任何水溶性(两亲性或亲水性)聚合物部分、PEG的均聚物或共聚物、PEG(mPEG)和聚氧乙烯甘油(POG)的单甲基取代的聚合物、聚氨基酸如聚赖氨酸、聚谷氨酸、聚天冬氨酸，特别是L构型的那些，药理学无活性的蛋白质如白蛋白、明胶、脂肪酸、多糖、脂质氨基酸和葡聚糖。聚合物部分可以是直链或支链的，并且其可以具有500至40000Da、5000至10000Da、10000至5000Da的分子量。化合物(结合配偶体)可以是任何合适的细胞穿透化合物，如tat肽、穿膜肽、pep-1。化合物(结合配偶体)可以是抗体分子。化合物(结合配偶体)可以是亲脂性部分或聚合物部分。亲脂性取代基和聚合物取代基是本领域中已知的。亲脂性取代基包括形成酯、磺酰酯、硫酯、酰胺或磺酰胺的一部分的酰基、磺酰基、N原子、O原子或S原子。亲脂性部分可以包括具有4至30个C原子，优选为8至12个C原子的烃链。它可以是线性的或支链的、饱和的或不饱和的。烃链可被进一步取代。它可以是环烷烃或杂环烷烃。该肽可以在N-末端、C-末端或两者处被修饰。聚合物或化合物(结合配偶体)优选与氨基、羧基或硫基连接，并且可以通过任何氨基酸残基的侧链的N-末端或C-末端连接。聚合物或化合物(结合配偶体)可以与任何合适的残基的侧链缀合。聚合物或化合物(结合配偶体)可以通过间隔物缀合。间隔物可以是天然或非天然氨基酸、琥珀酸、赖氨酰、谷氨酰、天门冬氨酰、甘氨酰、β-丙氨酰、γ-氨基丁酰基。聚合物或化合物(结合配偶体)可以通过酯、磺酰酯、硫酯、酰胺、氨基甲酸酯、脲、磺酰胺缀合。本领域技术人员知道制备所述缀合物的合适方法。
“片段”是指蛋白质片段，通常选自SEQUENCE ID NO:1-16和353-355，且特别是选自那些选自SEQUENCE ID NO:17-70的蛋白质的区域。在一个实施方案中，片段的长度通常为3至37个连续的氨基酸。在一个实施方案中，片段的长度通常为5至37个连续的氨基酸。在一个实施方案中，片段的长度通常为5至37个连续的氨基酸。片段通常具有-9至+3的电荷；通常为通常不是半胱氨酸(C)或蛋氨酸(M)的c-末端氨基酸；并且通常为通常不是半胱氨酸(C)、组氨酸(H)、脯氨酸(P)或苏氨酸(T)的n-末端氨基酸。使用Cameselle,J.C.,Ribeiro,J.M.和Sillero,A.(1986).Derivation and use of a formula to calculate the netcharge of acid-base compounds.Its application to amino acids,proteins andnucleotides(推导和使用公式来计算酸碱化合物的净电荷。其应用于氨基酸、蛋白质和核苷酸).Biochem.Educ.14,131-136的方法测定肽、片段或区域的电荷。
应用于肽的术语“天然”意指一肽，其包括(a)植物蛋白质的片段，植物蛋白通常为大米或豌豆蛋白质，或豌豆蛋白质的变体包括小扁豆(lentil)、甜豌豆或鹰嘴豆，或大米蛋白质的变体包括燕麦、草、玉米、野生稻和香蕉，或(b)植物蛋白质的片段的变体，例如植物蛋白质的同源物的片段。本发明的肽或片段可从植物蛋白质中分离或合成制备。
应用于片段的“C-末端结构域”意指片段的c-末端处的前三个氨基酸。
应用于片段的“N-末端结构域”意指片段的n-末端处的最后三个氨基酸。
应用于肽或片段的“生物活性”意指当施用给哺乳动物时具有健康促进作用，例如葡萄糖转运促进、抗细菌、抗炎或促进细胞生长或增殖中的一种或多种。在一个实施方案中，术语“生物活性”意指抗炎。
应用于肽或变体或片段的“葡萄糖转运促进”或“葡萄糖转运促进活性”意指当在以下体外测定中以2μM的浓度使用时，与未处理对照相比，能够增加GLUT4易位至骨骼肌中的肽、变体或片段。在10％的FBS和2μg/ml的杀稻瘟菌素中培养L6-GLUT4myc细胞。使细胞生长48-72小时，然后在24-孔板中在2％的FBS中以每孔15,000个细胞接种，并在实验之前使其分化6至8天。使L6-GLUT4myc细胞血清饥饿3小时，然后分别使用100nM的胰岛素孵育30分钟，或者使用200、20、2.0和0.2μM的SP以及2、1、0.5和0.25mg/ml的肽组合物孵育3小时。基于先前的发现选择3小时的孵育期，该发现确定了使用含有支链氨基酸的二肽孵育3小时增加了L6肌管1中的葡萄糖摄取。为了确定在同一时间点的GLUT4myc易位，将处理交错进行。通过抗体偶联比色测定法测量细胞表面上的myc标记的GLUT4的量。简略地说，在分别使用胰岛素孵育30分钟或用合成肽或肽组合物孵育3小时后，通过使用3％的多聚甲醛(PFA)孵育来固定L6-GLUT4myc细胞。然后，加入0.1M的甘氨酸溶液以淬灭PFA，并用5％的山羊血清阻断细胞。将肌管单层暴露于抗myc抗体，然后使用过氧化物酶缀合的驴抗小鼠IgG孵育。向每个孔中加入1mL的邻苯二胺二盐酸盐(OPD)试剂，并通过加入250μl/孔的3M的HCl终止该反应。为了确定GLUT4易位至细胞表面，使用492nm处的吸光度，在酶标仪上通过分光光度法测定每一条件的测量的等分试样。优选地，与未处理的对照相比，所述肽或片段能够使GLUT4易位增加至少50％(即，GLUT4易位的相对单位增加为1％-1.5％)。
应用于肽或片段的“抗细菌”或“抗细菌活性”意指在以下基于琼脂板的生长抑制测定中能够可见地抑制细菌生长的肽或片段：溶于DMSO中的肽储液＝5mg/mL。将细菌接种物调整至McFarland 0.5标准，并将MHA板擦拭。将空白盘置于板中，并加入10μL的每种化合物(在64μg/mL-最大测试浓度下)。将板在37℃下孵育16-18小时。还进行了适当的对照(DMSO；单独的Mueller-Hinton培养基；以及两种抗生素片-环丙沙星和四环素)。
应用于肽或片段的“抗炎”意指当用100μM的肽或片段处理LPS刺激的J774.2巨噬细胞时，能够显著减少巨噬细胞的TNFα分泌(与未处理的LPS刺激的J774.2巨噬细胞相比)的肽或片段。将J774.2巨噬细胞用100μM的合成肽处理24小时，然后用(A)LPS(10ng/ml)刺激5小时或(B)LPS(10ng/ml)刺激5小时，然后用ATP(5mM)刺激1小时。收集上清液并通过ELISA测定TNFα的水平。
应用于肽或片段的“细胞生长促进”或“细胞生长或增殖促进”意指在以下测定中能够增加使用20μM的肽或片段的溶液处理的人类皮肤的弹性蛋白产生或细胞增殖的肽或片段。从腹部整形手术制备皮肤外植体。将一些外植体用酒精脱脂以获得脱水皮肤。将这些外植体维持在供应商Bioprédic International提供的维持培养基中5天。测试项目每天施用两次，其中每个外植体5μL。在测试结束时，在两个外植体上用MTT实现活力对照，将第三外植体固定在4％的甲醛中用于组织学和细胞染色。对于每次分析(D1和D5)，进行脱脂外植体、用测试项目处理的外植体、DMSO 0.3％对照和水对照的组织学分析。在实验室收到之后，在3小时期间用5μL的酒精将维持培养基中的每个皮肤外植体脱脂。3小时后，将所有皮肤外植体每天用测试项目处理两次，并将它们在37℃±2℃，5％的CO2下孵育1天或5天。在第1天和第5天使用MTT用活力对照实现系统的完整性。由实验室Gredeco实现组织学分析，并由同一实验室实现弹性蛋白和Ki67的免疫染色。由实验室Intertek实现丝聚蛋白的免疫染色。使用免疫过氧化物酶技术两层(ABC试剂盒，Vector Laboratories)进行弹性蛋白(兔单克隆抗体，克隆P15502，LSBio)的检测，并通过AEC(3-氨基-9-乙基咔唑)显示。使用半定量组织学评分评估弹性纤维中的免疫组织化学染色强度。使用抗Ki67抗体通过免疫组织化学分析上皮细胞增殖。使用间接免疫过氧化物酶技术三层进行免疫检测，扩增(DAKO试剂盒)并通过AEC(3-氨基-9-乙基咔唑)显示。对标记细胞(表皮基底层的角质形成细胞)的数量进行计数，并提供基底细胞的总数以计算标记细胞的百分比。用免疫过氧化物酶染色(ABC试剂盒，Fisher)进行丝聚蛋白的特异性染色。相对于溶剂的阴性对照(水或DMSO0.3％)评估表皮中的免疫组织化学标记的强度。
应用于本发明组合物的“富含具有小于10KD的分子量的肽”意指组合物中分子量小于10KD的肽的干重％大于组合物中分子量为10KD或更高的多肽/蛋白质的干重％。
参考蛋白质的“同源物”应被理解为意指来自与参考蛋白质具有至少60％序列同源性的不同植物物种的蛋白质。因此，例如，豌豆蛋白质P13918的同源物包括：
＞gi|137584|sp|P08438.1|VCL_VICFA RecName：完整＝豌豆球蛋白；标志：前体[蚕豆]
＞gi|22057|emb|CAA68559.1|豌豆球蛋白(vicilin)[小蚕豆]＞gi|383931031|gb|AFH56916.1|豌豆球蛋白[蚕豆]
＞gi|502105533|ref|XP_004492829.1|预测的：豌豆球蛋白样亚型X1[鹰嘴豆(Cicer arietinum)]鹰嘴豆(ChickPea)
＞gi|29539109|emb|CAD87730.1|过敏原Len c 1.0101[兵豆(Lens culinaris)]小扁豆(Lentil)
抗炎片段的“变体”应被认为意指具有与抗炎片段基本相同的氨基酸序列的片段，并且其具有如上定义的抗炎活性。因此，例如，该术语应该被认为包括一个或多个氨基酸残基被改变的片段。优选地，这种改变涉及插入、添加、缺失和/或替换5个或更少的氨基酸，更优选为4个或更少，甚至更优选为3个或更少，最优选为仅1或2个氨基酸。设想用天然和经修饰的氨基酸插入、添加和替换。变体可具有保守氨基酸变化，其中被引入的氨基酸在结构上、化学上或功能上类似于被替换的氨基酸。通常，变体具有与亲本抗炎片段至少70％的氨基酸序列同源性，优选为至少80％的序列同源性，更优选为至少90％的序列同源性，并且理想地为至少95％、96％、97％、98％或99％的序列同源性。
在本说明书中，术语“序列同一性”应理解为包含序列同一性和相似性二者，即与参考序列共享70％的序列同一性的变体(或同源物)是其中变体(或同源物)的任何70％的比对残基在整个序列长度上与参考序列中的相应残基相同或是其保守替换的变体(或同源物)。序列同一性是两个不同序列之间完全匹配的字符(character)的量。因此，缺口不计算在内，并且测量与两个序列中较短的一个相关。就“序列同源性”而言，该术语应被理解为意指当变体(或同源物)的比对残基的百分比与参考序列中的相应残基相同或是其保守替换时并且在变体(或同源物)与参考序列共享相同的功能的情况下，与参考序列共享限定的百分比相似性或同一性的变体(或同源物)。该比对和百分比同源性或序列同一性可以使用本领域已知的软件程序来确定，例如，一个比对程序是使用默认参数的BLAST。这些程序的详细信息可以在以下Internet网址获悉：http：//www.ncbi.nlm.nih.gov/blaSt/Blast.cgi。
SEQUENCE ID NO：109的变体(抗炎肽(I_37)
以下提供SEQUENCE ID NO：109(RGPQQYAEWQINEK)的变体，包括具有1、2或3个保守氨基酸替换，1、2至3个非保守氨基酸替换，1-2个氨基酸添加，1、2或3个氨基酸缺失的变体：
一个保守氨基酸替换：
RGPQQYAEWQINER， RGPQQYAEWQINDK， RGPQQFAEWQINEK，
KGPQQYAEWQINEK， RGPEQYAEWQINEK. RGPQEYAEWQINEK，
RGPQQYADWQINEK，RGPQQYAEYQINEK(SEQ ID NO 268275)
两个保守氨基酸替换：
KGPEQYAEWQINEK. KGPQEYAEWQINEK. KGPQQFAEWQINEK，
RGPEQFAEWQINEK， KGPQQYAEWQINER， RGPQQYAEWQINDR，
RGPQQYADWQINDK，RGPQQFAEWQINER(SEQ ID NO 276-283)
三个保守氨基酸替换：
RGPQQYAEWQVNEK， RGPQQFAEWQINEK， KGPQQFAEWQINER，
KGPQQFAEWQVNEK， RGPQQFAEWQVNDK， RGPQQYADWQINDR，
KGPQQYADWQINDK，RGPQQFADYQINEK(SEQ ID NO 284-291)
一个非保守氨基酸替换
RGPQQYARWQINEK， RGPQQYAEWQINEE， HGPQQYAEWQINEK，，
RGPYQYAEWQINEK， RGPQQYMEWQINEK， RGPQQYAEWCINEK，
RGPQPYAEWQINEK(SEQ ID NO 292-298)
两个非保守氨基酸替换
RGGQQYAEWQINED， RGPQQYARWKINEK， RGGQQYAETQINEK，
RGPLQYAEWQNNEK， EGPQQYAEWQINED， RGPQQYAEWQINLL，
RGPQQGGEWQINEK(SEQ ID NO 299-305)
三个非保守氨基酸替换
RGPQQYAEWQIGGG，RGPQQKYEWQINEK， RGPQAQYEWQINEK，
RPHQQYAEWQINEK，RGPQHHHEWQINEK， RGPPQYAPPQINEK，
RGPQCYYEWCINEK，RGPTQYAEGQINEG(SEQ ID NO 306-313)
一个或两个氨基酸添加
RGPQQYAEWQINEKG， RGPQQYAEWQINEKY， RGPQQYAFTEWQINEK，
RGPQSQYAEWQINEKPM，RGPQQYAEWQINEKKK，RRRRGPQQYAEWQINEK(SEQ ID NO 314-319).
术语“变体”通常涵盖本发明的肽的片段。“本发明的肽的片段”或“肽片段”意指具有至少3、4、5、6、7、8、9、10、11、12、13、14、15、16、17、18、19、20、21或22个氨基酸并且通常具有生物活性，例如抗炎活性、细胞生长或增殖促进活性、葡萄糖转运促进活性或抗细菌活性的本发明的肽之一的片段。在一个实施方案中，该片段由至少30％、40％、50％、60％、70％、80％或90％的参考序列(reference Sequence)组成。在SEQUENCE ID NO 320-330中提供了本发明的片段的实例。
RGPQQYAEWQINE，RGPQQYAEWQIN，RGPQQYAEWQI，GPQQYAEWQINEK，PQQYAEWQINEK，QQYAEWQINEK，QQYAEWQI，PQQYAEWQINE，PQQYAEWQIN，RGPQQYA，EWQINEK(SEQ ID NO320-330)
“炎性紊乱”意指影响人类的免疫介导的炎性病况并且通常特征在于一种或多种细胞因子的异常表达(dysregulated expression)。炎性紊乱的实例包括皮肤炎性紊乱、关节炎性紊乱、心血管系统的炎性紊乱、某些自身免疫病、肺和气道炎性紊乱、肠道炎性紊乱。皮肤炎性紊乱的实例包括皮炎，例如特应性皮炎和接触性皮炎、寻常痤疮和银屑病。关节炎性紊乱的实例包括类风湿性关节炎。心血管系统炎性紊乱的实例是心血管疾病和动脉粥样硬化。自身免疫疾病的实例包括1型糖尿病、格雷夫斯病、格林-巴利病、狼疮、银屑病关节炎和溃疡性结肠炎。肺和气道炎性紊乱的实例包括哮喘、囊性纤维化、COPD、肺气肿和急性呼吸窘迫综合征。肠道炎性紊乱的实例包括结肠炎和炎性肠病。其它炎性紊乱包括癌症、枯草热、牙周炎、变态反应、超敏反应、缺血、抑郁症、全身性疾病、感染后炎症和支气管炎。
在本说明书中，术语“代谢紊乱”应被理解为包括前期糖尿病、糖尿病；1型糖尿病；2型糖尿病；代谢综合征；肥胖；糖尿病血脂异常；高脂血症；高血压；高甘油三酯血症；高脂肪酸血症；高胆固醇血症；高胰岛素血症和MODY。
应用于可食产品的“人造”应被理解为意指由人类制造而不存在于自然界中。
“维持或恢复肠道健康”意指减少和/或调节肠道中且更具体地为上皮细胞中的促炎反应。健康的微生物组提供抵御致病病毒和细菌的一定的保护，并且需要它们的存在以引导我们的免疫系统的发展。已经表明，这些细菌可以对人体的应激、生病或年龄的信号作出反应，这些信号可以通过炎症表现出来，并因此开启它们的致病基因并导致或促成疾病。具有减少炎症反应和将炎症反应维持在健康水平的能力，可以帮助维护健康细菌。消化问题包括北美洲的头号健康问题近年来似乎更频繁地出现。维持消化健康的一个方法是维持适当的发炎和肠道菌群。
“维持或恢复肌肉健康”意指帮助保持或恢复运动过程中出现的损伤所引起的哺乳动物肌肉健康。通过减少炎症，肽促进运动过程中的损伤恢复，并减轻肌肉酸痛/疼痛和运动相关的损伤。它们还可以用来减少和防止肌肉痉挛，并允许从肌肉痉挛的较快恢复。痉挛可由躯体应激、心理应激和/或重复性劳损应激造成的。通过减少炎症，肽有助于减少肌肉肌病，并有助于预防哺乳动物的肌肉减少症，促进运动过程中的损伤恢复，并减轻肌肉酸痛/运动相关的疼痛和损伤。它们还可以用来减少和防止肌肉痉挛，并允许从肌肉痉挛快速恢复。痉挛可能是由躯体应激、心理应激和/或重复性压迫损伤应激造成的。通过减少炎症，肽有助于减少肌肉肌病，并有助于预防哺乳动物的肌肉减少症。
在本说明书中，术语“组合物”应被理解为意指由人手工制造的东西，并且不排除天然存在的组合物。示例性的组合物包括食物、饮料、营养补充剂、个人护理组合物和药物组合物。
在本说明书中，应用于肽或片段的清单的术语“基本上全部”应被理解为意指肽或片段的至少60％、70％、80％、90％或95％。
在本说明书中，术语“个人护理组合物”应被理解为意指被配制用于人类清洁或处理人体，特别是皮肤、牙齿、指甲、脚和头发的组合物。实例包括洗发水、护发素、护肤霜和乳液、粉末、牙膏、沐浴露或乳霜、身体乳、除臭剂和止汗剂。
在本说明书中，术语“营养补充剂”应被理解为意指配制用于哺乳动物消化并旨在赋予接受者健康益处的产品。补充剂可以采取任何形式，例如固体、液体或粉末。补充剂的实例包括粉剂、片剂、胶囊剂和饮料。
附图说明
图1至18：本发明的十八种合成肽对THP1细胞中TNF-分泌的作用。在三个板上一式两份地(6孔/条件)准备所有实验。使用Students t检验计算显著性(与对照相比*p<0.05，与对照相比**p<0.01，与对照相比***p<0.001)
图19.用合成肽处理后J774.2巨噬细胞的活力。在进行阿尔玛蓝(alamar blue)测定之前，用100μM的合成肽将J774.2巨噬细胞处理24小时。数据表示为n＝3+/-SEM的平均值。
图20.肽组合物对细胞存活的影响。在进行alamar blue测定之前，用(A)1mg/ml或(B)0.5mg/ml的肽组合物将J774.2巨噬细胞处理24小时。数据显示为(A)n＝1+/-SEM和(B)n＝3+/-SEM。
图21：DMSO载体对来自J774.2巨噬细胞的TNFα和IL-1β分泌的影响。将J774.2巨噬细胞用终浓度为0.3％和1％的DMSO(相当于用于溶解肽的量)处理24小时，并确定刺激后对TNFα和IL-1β的影响。数据表示为n＝3+/-SEM的平均值。(***p<0.001w.r.t LPS)。
图22.本发明的六种肽对来自J774.2巨噬细胞的TNFα和IL-1β分泌的影响。将J774.2巨噬细胞用100μM的合成肽处理24小时，然后用(A)LPS(10ng/ml)刺激5小时或(B)LPS(10ng/ml)刺激5小时，然后用ATP(5mM)刺激1小时。收集上清液并通过ELISA测定(A)TNFα和(B)IL-1β的水平。(***p<0.001w.r.t LPS，**p<0.01w.r.t LPS，*p<0.05，###p<0.001w.r.t.LPS/ATP，##p<0.01w.r.t LPS/ATP和#p<0.05w.r.t LPS/ATP)。孔中的DMSO的最终浓度：SP1-0.3％，SP2-0％，SP3-0.3％，SP4-1％，SP5-1％，SP6-0.3％，阳性对照-0％。数据表示为n＝3+/-SEM的平均值。
图23：本发明的肽组合物对TNFα和IL-1β分泌的影响。将J774.2巨噬细胞用0.5mg/ml的肽组合物处理24小时，然后用(A)LPS(10ng/ml)刺激5小时或(B)LPS(10ng/ml)刺激5小时，然后用ATP(5mM)刺激1小时。收集上清液并通过ELISA测定(A)TNFα和(B)IL-1β的水平。(***p<0.001w.r.t未处理的+LPS，###p<0.001w.r.t.未处理的+LPS/ATP)。数据表示为n＝3+/-SEM的平均值。
图24.合成肽与DMSO载体对TNFα的影响。将J774.2巨噬细胞用100μM的合成肽处理24小时，然后用LPS(10ng/ml)处理5小时。收集上清液并通过ELISA测定TNFα的水平。###p<0.001w.r.t 0.3％DMSO+LPS，##p<0.01w.r.t.0.3％DMSO+LPS，+++p<0.001w.r.t 1％DMSO+LPS，++p<0.01w.r.t 1％DMSO+LPS/ATP)。孔中的DMSO的最终浓度：阳性对照-0％，SP1-0.3％，SP2-0％，SP3-0.3％，SP4-1％，SP5-1％，SP6-0.3％。
图25.在LPS刺激之前，将用本发明的大米肽的组合物(I_2_HR)处理24小时的THP-1分化的巨噬细胞与未处理的细胞比较。与未处理的细胞相比，I_2_HR处理的细胞中的TNF-α分泌减少了92％。在100ug/ml和500ug/ml浓度的I_2_HR下观察到显著的结果，表明I_2_HR的效力。
图26至28.本发明的三种合成肽对THP1细胞中的TNF-分泌的影响。在三个板上一式两份地(6孔/条件)准备所有实验。使用Students t检验计算显著性(与对照相比*p<0.05，与对照相比**p<0.01，与对照相比***p<0.001)。
具体实施方式
实施例1-炎性反应
响应于内毒素如脂多糖(LPS)的刺激，巨噬细胞分泌TNF-α。TNF-α被认为与全身性炎症有关，且TNF-α产生的调节异常被认为与许多疾病有关。Biolegend测定是一种夹心ELISA试剂盒，其被设计用于从细胞培养上清液、血清或血浆中精确定量人TNF-α。
在含有10％的胎牛血清(FCS)、1％的青霉素/链霉素(Pen/strep)、1％的L-谷氨酰胺、100nM的PMA的RPMI中，将THP-1单核细胞以10,000个细胞/孔接种在96孔板中，并在实验之前使其分化72小时。
分化后，分别用100ng/ml、10ng/ml或1ng/ml的合成肽将细胞孵育24小时。
处理后，用10ng/ml的LPS刺激细胞5小时，使用Biolegend测定ELISA试剂盒确定上清液中TNF-α的量。
结果以未处理的对照的百分比形式计算。光密度读数的增加表明更大的量的TNF-α释放到细胞培养物上清液中。
结果提供在图1至21中并总结于下表1中。在三个板上一式两份地(6孔/条件)准备所有实验。使用Student t检验计算显著性(与对照相比*p<0.05，与对照相比**p<0.01，与对照相比***p<0.001)。
表1
| 图号 | SEQ ID | TNF-α减少 |
| 图1 | 339 | 26％ |
| 图2 | 352 | 23％ |
| 图3 | 341 | 21％ |
| 图4 | 351 | 18％ |
| 图5 | 144 | 16％ |
| 图6 | 93 | 14％ |
| 图7 | 320 | 13％ |
| 图8 | 92 | 13％ |
| 图9 | 75 | 11％ |
| 图10 | 76 | 9％ |
| 图11 | 349 | 6％ |
| 图12 | 350 | |
| 图13 | 105 | 9％ |
| 图14 | 177 | |
| 图15 | 345 | 23％ |
| 图16 | 353 | 20％ |
| 图17 | 344 | 20％ |
| 图18 | 346 | 18％ |
| 图26 | 85 | 80％ |
| 图27 | 91 | 80％ |
| 图28 | 420 | 80％ |
实施例2-炎性反应
测定本发明的六种合成肽SP1至SP6(SEQUENCE ID NO：108、109、110、111、85和91)和四种肽组合物对使用细胞系的体外炎性反应的影响。
肽组合物I_1_HR(大米)含有以下肽(通过SEQ ID确定)：116、197、207、112、211、158、201、203、114、183、130、113、182、167、166、152、220、213、215、154、219、218、165、123、185、190、209、181、198、200、147、172、184、124、153、205、115、196、151、161、160、216、210、208、146、133、204、212、206。
肽组合物I_2_HR(大米)含有以下肽(通过SEQ ID确定)：189、177、174、129、176、202、193、195、194、192、182、128、220、127、134、136、135、180、179、178、219、218、145、120、175、190、149、126、187、191、121、122、159、132、162、137、150、186、188、164、118、125、163、157、156、117。
肽组合物E_1_HR(豌豆)含有以下肽(通过SEQ ID确定)：74、76、106、102、101、100、92、96、83、89、90、104、82、75、79、78、77、99、103、72、86、105、94、93、81、97、80、88、85、87、71、107、73、84、98、95。
肽组合物E_2_HR(豌豆)含有本发明的肽的同源物。
用100μM的每种合成肽(Sp)和0.5mg/ml的每种肽组合物处理J774.2小鼠巨噬细胞系，并在使用脂多糖(LPS)作为炎性刺激物诱导炎症后测定对两种促炎症标志物-肿瘤坏死因子α(TNFα)和白细胞介素-1β(IL-1β)的影响。将单因素方差分析与多重比较的dunnet检验一起使用，并将每个平均值与单个对照平均值进行比较。
实施例3-合成肽：细胞活力
首先将合成肽在合适的溶剂中稀释。二甲亚砜(DMSO)是选择用于预测水溶性差的肽的溶剂。每个孔中的DMSO的最终浓度：SP1(1_155_HR)-0.3％、SP2(1_374_HR)-0％、SP3(E_155_HR)-0.3％、SP4(E_54_HR)-1％、SP5(E_41_HR)-1％、SP6(E_788_HR)-0.3％、阳性对照-0％。在进行alamar blue测定之前，首先用100μM的每种SP处理细胞24小时。用任何肽都没有发现活力问题。
实施例4-肽组合物：制备和毒性
通过将pH调节至6-7和无菌过滤来制备肽组合物。测定肽组合物对细胞活力的影响。J774.2巨噬细胞用1mg/ml和0.5mg/ml的每种肽组合物处理、用过氧化氢处理以诱导细胞死亡作为阳性对照，以及用一已知是无毒的肽作为阴性对照。然后，进行alamar blue测定，并且细胞存活在图19中显示为未处理(100％)的百分比。由于1mg/ml的肽损害细胞存活，因而将0.5mg/ml的肽组合物用于进一步测定。
实施例5-炎性标志物
测定DMSO对TNFα和IL-1β分泌的影响。1％的DMSO显著增加TNFα的水平(图3A，***p<0.001w.r.t LPS)，并且在分析肽对TNFα的影响时将其考虑在内。对于DMSO和IL-1β分泌没有观察到显著的效果。
实施例6-炎性反应
用本发明的大米肽的组合物(I_2_HR)处理24小时的THP-1分化的巨噬细胞，然后用LPS刺激，与未处理的细胞进行比较。与未处理的细胞相比，I_2_HR处理的细胞中的TNF-α分泌减少了92％。在100ug/ml和500ug/ml浓度的I_2_HR下观察到显著的结果，表明I_2_HR的效力。
本发明不限于前面描述的实施方案，在不脱离本发明的精神的情况下，其可以在结构和细节上进行改变。
序列信息
豌豆蛋白质1：P13918-1-
MAATTMKASFPLLMLMGISFLASVCVSSRSDPQINPFIFKSNKFQTLFENENGHIRLLQKFDQRSKIFENLQNYRLLEYKSKPHTIFLPQHTDADYILVVLSGKAILTVLKPDDRNSFNLERGDTIKLPAGTIAYLVNRDDNEELRVLDLAIPVNRPGQLQSFLLSGNQNQQNYLSGFSKNILEASFNTDYEEIEKVLLEEHEKETQHRRSLKDKRQQSQEENVIVKLSRGQIEELSKNAKSTSKKSVSSESEPFNLRSRGPIYSNEFGKFFEITPEKNPQLQDLDIFVNSVEIKEGSLLLPHYNSRAIVIVTVNEGKGDFELVGQRNENQQEQRKEDDEEEEQGEEEINKQVQNYKAKLSSGDVFVIPAGHPVAVKASSNLDLLGFGINAENNQRNFLAGDEDNVISQIQRPVKELAFPGSAQEVDRILENQKQSHFADAQPQQRERGSRETRDRLSSV[SEQ ID 1]
区域：253至274-PFNLRSRGPIYSNEFGKFFEIT[SEQ ID 17]
肽：SRGPIYSNEFGK[SEQ ID 71]
区域：110至126-KPDDRNSFNLERGDTIK[SEQ ID 18]
肽：NSFNLER[SEQID 72]
区域：134至160-YLVNRDDNEELRVLDLAIPVNRPGQLQ[SEQ ID 19]
肽：VLDLAIPVNR[SEQ ID 73]
肽：DDNEELR[SEQ ID 74]
区域：331至381-QEQRKEDDEEEEQGEEEINKQVQNYKAKLSSGDVFVIPAGHPVAVKASSNL[SEQID 20]
肽：LSSGDVFVIPAGHPVAVK[SEQ ID 75]
肽：EDDEEEEQGEEEINK[SEQ ID 76]
区域：175至242-SGFSKNILEASFNTDYEEIEKVLLEEHEKETQHRRSLKDKRQQSQEENVIVKLSRGQIEELSKNAKST[SEQ ID 21]
肽：NILEASFNTDYEEIEKVLLEEHEKETQHR[SEQ ID 77]
肽：NILEASFNTDYEEIEKVLLEEHEK[SEQ ID 78]
肽：NILEASFNTDYEEIEK[SEQ ID 79]
肽：RQQSQEENVIVK[SEQ ID 80]
肽：QQSQEENVIVK[SEQ ID 81]
肽：LSRGQIEELSK[SEQ ID 82]
肽：GQIEELSK[SEQ ID 83]
肽：VLLEEHEK[SEQ ID 84]
区域：35至108-PFIFKSNKFQTLFENENGHIRLLQKFDQRSKIFENLQNYRLLEYKSKPHTIFLPQHTDADYILVVLSGKAILTV[SEQ ID 22]
肽：SKPHTIFLPQHTDADYILVVLSGK[SEQ ID 85]
肽：PHTIFLPQHTDADYILVVLSGK[SEQ ID 86]
肽：SNKFQTLFENENGHIR[SEQ ID 87]
肽：SKIFENLQNYR[SEQ ID 88]
肽：IFENLQNYR[SEQ ID 89]
区域：423至450-QEVDRILENQKQSHFADAQPQQRERGSR[SEQ ID 23]
肽：ILENQKQSHFADAQPQQR[SEQ ID 90]
肽PGQLQSFLLSGNQNQQNYLSGFSK[SEQ ID 91]
豌豆蛋白质2：P02856-2-
DRRQELSNENVLVKVSRRQLEELSKNAKSSSRRSVSSESGPFNLRSEDPLYSNNSGKFFELTPEKNQQLQDLDLFVNSVDLKEGSLLLPNYNSRALLVLVLVVNEGKGDFELVGQRNENQGKEN[SEQ ID 2]
区域：53至87-NNSGKFFELTPEKNQQLQDLDLFVNSVDLKEGSLL[SEQ ID 24]
肽：FFELTPEKNQQLQDLDLFVNSVDLK[SEQ ID 92]
区域：14至30-KVSRRQLEELSKNAKSS[SEQ ID 25]
肽：QLEELSK[SEQ ID 93]
豌豆蛋白质3：P15838-3-
MATKLLALSLSFCFLLLGGCFALREQPEQNECQLERLNALEPDNRIESEGGLIETWNPNNKQFRCAGVALSRATLQHNALRRPYYSNAPQEIFIQQGNGYFGMVFPGCPETFEEPQESEQGEGRRYRDRHQKVNRFREGDIIAVPTGIVFWMYNDQDTPVIAVSLTDIRSSNNQLDQMPRRFYLAGNHEQEFLRYQHQQGGKQEQENEGNNIFSGFKRDFLEDAFNVNRHIVDRLQGRNEDEEKGAIVKVKGGLSIISPPEKQARHQRGSRQEEDEDEDEERQPRHQRGSRQEEEEDEDEERQPRHQRRRGEEEEEDKKERRGSQKGKSRRQGDNGLEETVCTAKLRLNIGPSSSPDIYNPEAGRIKTVTSLDLPVLRWLKLSAEHGSLHKNAMFVPHYNLNANSIIYALKGRARLQVVNCNGNTVFDGELEAGRALTVPQNYAVAAKSLSDRFSYVAFKTNDRAGIARLAGTSSVINNLPLDVVAATFNLQRNEARQLKSNNPFKFLVPARQSENRASA[SEQID 3]
区域：267至287-QRGSRQEEDEDEDEERQPRHQ[SEQ ID 26]
肽：QEEDEDEDEER[SEQ ID94]
区域：190至222-QEFLRYQHQQGGKQEQENEGNNIFSGFKRDFLE[SEQ ID 27]
肽：YQHQQGGKQEQENEGNNIFSGFK[SEQ ID 95]
豌豆蛋白质4：Q9M3X6-4-
MATTIKSRFPLLLLLGIIFLASVVCVTYANYDEGSEPRVPAQRERGRQEGEKEEKRHGEWRPSYEKEEDEEEGQRERGRQEGEKEEKRHGEWRPSYEKQEDEEEKQKYRYQREKEDEEEKQKYQYQREKKEQKEVQPGRERWEREEDEEQVDEEWRGSQRREDPEERARLRHREERTKRDRRHQREGEEEERSSESQERRNPFLFKSNKFLTLFENENGHIRLLQRFDKRSDLFENLQNYRLVEYRAKPHTIFLPQHIDADLILVVLSGKAILTVLSPNDRNSYNLERGDTIKLPAGTTSYLVNQDDEEDLRLVDLVIPVNGPGKFEAFDLAKNKNQYLRGFSKNILEASYNTRYETIEKVLLEEQEKDRKRRQQGEETDAIVKVSREQIEELKKLAKSSSKKSLPSEFEPINLRSHKPEYSNKFGKLFEITPEKKYPQLQDLDLFVSCVEINEGALMLPHYNSRAIVVLLVNEGKGNLELLGLKNEQQEREDRKERNNEVQRYEARLSPGDVVIIPAGHPVAITASSNLNLLGFGINAENNERNFLSGSDDNVISQIENPVKELTFPGSVQEINRLIKNQKQSHFANAEPEQKEQGSQGKRSPLSSILGTFY[SEQ ID 4]
区域：284至317-YNLERGDTIKLPAGTTSYLVNQDDEEDLRLVDLV[SEQ ID 28]
肽：GDTIKLPAGTTSYLVNQDDEEDLR[SEQ ID 96]
区域：321至400-
NGPGKFEAFDLAKNKNQYLRGFSKNILEASYNTRYETIEKVLLEEQEKDRKRRQQGEETDAIVKVSREQIEELKKLAKSS[SEQ ID 29]
肽：RQQGEETDAIVK[SEQ ID 97]
肽：VLLEEQEKDRK[SEQ ID 98]
肽：NILEASYNTR[SEQ ID 99]
肽：FEAFDLAK[SEQ ID 100]
肽：EQIEELKK[SEQ ID 101]
肽：EQIEELK[SEQ ID 102]
肽：NKNQYLR[SEQ ID 103]
区域：503至549-RYEARLSPGDVVIIPAGHPVAITASSNLNLLGFGINAENNERNFLSG[SEQ ID30]
肽：LSPGDVVIIPAGHPVAITASSNLNLLGFGINAENNER[SEQ ID 104]
区域：89至112-HGEWRPSYEKQEDEEEKQKYRYQR[SEQ ID 31]
肽：PSYEKQEDEEEKQK[SEQ ID 105]
区域：62至80-PSYEKEEDEEEGQRERGRQ[SEQ ID 32]
肽：EEDEEEGQR[SEQ ID 106]
豌豆蛋白质5：D3VNE1-5-
MAATPIKPLMLLAIAFLASVCVSSRSDQENPFIFKSNRFQTLYENENGHIRLLQKFDKRSKIFENLQNYRLLEYKSKPRTLFLPQYTDADFILVVLSGKATLTVLKSNDRNSFNLERGDTIKLPAGTIAYLANRDDNEDLRVLDLTIPVNKPGQLQSFLLSGTQNQPSLL5GFSKNILEAAFNTNYEEIEKVLLEQQEQEPQHRRSLKDRRQEINEENVIVKVSREQIEELSKNAKSSSKKSVSSESGPFNLRSRNPIYSNKFGKFFEITPEKNQQLQDLDIFVNSVDIKEGSLLLPNYNSRAIVIVTVTEGKGDFELVGQRNENQGKENDKEEEQEEETSKQVQLYRAKLSPGDVFVIPAGHPVAINASSDLNLIGFGINAENNERNFLAGEEDNVISQVERPVKELAFPGSSHEVDRLLKNQKQSYFANAQPLQRE[SEQ ID 5]
肽：75至104-KSKPRTLFLPQYTDADFILVVLSGKATLTV[SEQ ID 33]
肽：TLFLPQYTDADFILVVLSGK[SEQ ID 107]
大米蛋白质7：Q6K508
MATTTSLLSSCLCALLLAPLFSQGVDAWESRQGASRQCRFDRLQAFEPLRKVRSEAGDTE
YFDERNEQFRCAGVFVIRRVIEPQGLVVPRYSNTPALAYIIQGKGYVGLTFPGCPATHQQ
QFQLFEQRQSDQAHKFRDEHQKIHEFRQ6DVVALPASVAHWFYNGGDTPAVVVYVYDIKS
FANQLEPRQKEFLLAGNNQRGQQIFEHSIFQHSGQNIFSGFNTEVLSEALGINTEASKRL
QSQNDQRGDIIRVKHGLQLLKPTLTQRQEEHRQYQQVQYREGQYNGLDENFCTIKARVNI
ENPSRADYYNPRAGRITLLNNQKFPILNLIGMGAARVNLYQNALLSPFWNINAHSVVYII
QGSVRVQVANNQGRSVFNGVLHQGQLLIIPQNHAVIKKAEHNGCQYVAIKTISDPTVSWV
AGKNSILRALPVDVIANAYRISRDEARRLKNNRADEIGPFTPRFPQKSQRGYQFLTEGLS
LIGM [SEQ ID 6]
肽：GYVGLTFPGCPATHQQQFQLFEQR[SEQ ID 108]
大米蛋白质8：Q6K7K6
MASMSTILPLCLGLLLFFQVSMAQFSFGGSPLQSPRGFRGDQDSRHQCRFEHLTALEATH
QQRSEAGFTEYYNIEARNEFRCAGVSVRRLVVESKGLVLPMYANAHKLVYIVQGRGVFGM
ALPGCPETFQSVRSPFEQEVATAGEAQSSIQKMRDEHQQLHQFHQGDVIAVPAGVAHWLY
NNGDSPVVAFTVIDTSNNANQLDPKRREFFLAGKPRSSWQQQSYSYQTEQLSRNQNIFAG
FSPDLLSEALSVSKQTVLRLQGLSDPRGAIIRVENGLQALQPSLQVEPVKEEQTQAYLPT
KQLQPTWLRSGGACGQQNVLDEIMCAFKLRKNIDNPQSSDIFNPHGGRITRANSQNFPIL
NIIQMSATRIVLQNNALLTPHWTVNAHTVMYVTAGQGHIQVVDHRGRSVFDGELHQQQIL
LIPQNFAVVVKARREGFAWVSFKNHNAVDSQIAGKASIL.RALPVDVVANAYRLSREDSR
HVKFNRGDEMAVFAPRRGPQQYAEWQINEK[SEQ ID 7]
肽：RGPQQYAEWQINEK[SEQ ID 109]
豌豆蛋白质6：P13919
MATTIKSRFPLLLLLGIIFLASVVSVTYANYDEGSEPRVPAQRERGRQEGEKEEKRHGEW
RPSYEKEEDEEEGQRERGRQEGEKEEKRHGEWGPSYEKQEDEEEKQKYRYQREKEDEEEK
QKYQYQREKKEQKEVQPGRERWEREEDEEQVDEEWRGSQRREDPEERARLRHREERTKRD
RRHQREGEEEERSSESQERRNPFLFKSNKFLTLFENENGHIRLLQRFDKRSDLFENLQNY
RLVEYRAKPHTIFLPQHIDADLILVVLSGKAILTVLSPNDRNSYNLERGDTIKLPAGTTS
YLVNQDDEEDLRLVDLVIPVNGPGKFEAFDLAKNKNQYLRGFSKNILEASYNTRYETIEK
VLLEEQEKDRKRRQQGEETDAIVKVS[SEQ ID8]
肽：LVDLVIPVNGPGKFEAFDLAK[SEQ ID 110]
豌豆蛋白质7：P02855
MATTIKSRFPLLLLLGIIFLASVVSVTYANYDEGSEPRVPAQRERGRQE6EKEEKRHGEW
RPSYEKEEDEEEGQRERGRQEGEKEEKRHGEWGPSYEKQEDEEEKQKYRYQREKEDEEEK
QKYQYQREKKEQKEVQPGRERWEREEDEEQVDEEWRGSQRREDPEERARLRHREERTKRD
RRHQREGEEEERSSESQERRNPFLFKSNKFLTLFENENGHIRLLQRFDKRSDLFENLQNY
RLVEYRAKPHTIFLPQHIDADLILVVLSGKAILTVLSPNDRNSYNLERGDTIKLPAGTTS
YLVNQDDEEDLRLVDLVIPVNGPGKFEAFDLAKNKNQYLRGFSKNILEASYNTRYETIEK
VLLEEQEKDRKRRQQGEETDAIVKVS[SEQ ID 9]
肽：KNPQLQDLDIFVNYVEIK[SEQ ID 111]
大米蛋白质1：P14323-1-
MASSVFSRFSIYFCVLLLCHGSMAQLFNPSTNPWHSPRQGSFRECRFDRLQAFEPLRKVRSEAGVTEYFDEKNELFQCTGTFVIRRVIQPQGLLVPRYTNIPGVVYIIQGRGSMGLTFPGCPATYQQQFQQFSSQGQSQSQKFRDEHQKIHQFRQGDIVALPAGVAHWFYNDGDAPIVAVYVYDVNNNANQLEPRQKEFLLAGNNNRAQQQQVYGSSIEQHSGQNIFSGFGVEMLSEALGINAVAAKRLQSQNDQRGEIIHVKNGLQLLKPTLTQQQEQAQAQDQYQQVQYSERQQTSSRWNGLEENFCTIKVRVNIENPSRADSYNPRAGRITSVNSQKFPILNLIQMSATRVNLYQNAILSPFWNVNAHSLVYMIQGRSRVQVVSNFGKTVFDGVLRPGQLLIIPQHYAVLKKAEREGCQYIAIKTNANAFVSHLAGKNSVFRALPVDVVANAYRISREQARSLKNNRGEEHGAFTPRFQQQYYPGLSNESESETSE[SEQ ID 10]
区域：138至159-SQSQKFRDEHQKIHQFRQGDIV[SEQ ID 34]
肽：DEHQKIHQFR [SEQ ID112]
肽：FRDEHQK[SEQ ID 113]
区域：336至358-VNSQKFPILNLIQMSATRVNLYQ[SEQ ID 35]
肽：FPILNLIQMSATR[SEQ ID 114]
区域：423至462-YIAIKTNANAFVSHLAGKNSVFRALPVDVVANAYRISREQ[SEQ ID 36]
肽：TNANAFVSHLAGK[SEQ ID 115]
肽：ALPVDVVANAYR[SEQ ID 116]
区域：175至205-APIVAVYVYDVNNNANQLEPRQKEFLLAGNN[SEQ ID 37]
肽：YVYDVNNNANQLEPRQKEFL[SEQ ID 117]
肽：VYVYDVNNNANQLEPRQKEFL[SEQ ID 118]
区域：318至334-ENPSRADSYNPRAGRIT[SEQ ID 38]
肽：ADSYNPR[SEQ ID 119]
区域：265至296-GLQLLKPTLTQQQEQAQAQDQYQQVQYSERQQ[SEQ ID 39]
肽：KPTLTQQQEQAQAQDQ[SEQ ID 120]
肽:QAQAQDQYQQVQY[SEQ ID 121]
肽：QAQDQYQQVQY[SEQ ID 122]
区域：45至62-CRFDRLQAFEPLRKVRSE[SEQ ID 40]
肽：LQAFEPLR[SEQ ID 123]
区域：361至408-ILSPFWNVNAHSLVYMIQGRSRVQVVSNFGKTVFDGVLRPGQLLIIPQ[SEQ ID41]
肽：SRVQVVSNFGK [SEQ ID 124]
肽：WNVNAHSLVY[SEQ ID 125]
肽：NVNAHSLVY[SEQ ID 126]
肽：IQGRSRVQVVSNFGK[SEQ ID 127]
肽：GKTVFDGVLRPGQL[SEQ ID 128]
肽：FGKTVFDGVLRPGQL[SEQ ID 129]
区域：476至499-AFTPRFQQQYYPGLSNESESETSE[SEQ ID 42]
肽：FQQQYYPGLSNESESETSE[SEQ ID 130]
肽：QQYYPGLSN[SEQ ID 131]
肽：QQQYYPGLSN[SEQ ID 132]
大米蛋白质2：P07728-2-
MASINRPIVFFTVCLFLLCNGSLAQQLLGQSTSQWQSSRRGSPRECRFDRLQAFEPIRSVRSQAGTTEFFDVSNEQFQCTGVSVVRRVIEPRGLLLPHYTNGASLVYIIQGRGITGPTFPGCPESYQQQFQQSGQAQLTESQSQSQKFKDEHQKIHRFRQGDVIALPAGVAHWCYNDGEVPVVAIYVTDLNNGANQLDPRQRDFLLAGNKRNPQAYRREVEERSQNIFSGFSTELLSEALGVSSQVARQLQCQNDQRGEIVRVEHGLSLLQPYASLQEQEQGQVQSRERYQEGQYQQSQYGSGCSNGLDETFCTLRVRQNIDNPNRADTYNPRAGRVTNLNTQNFPILSLVQMSAVKVNLYQNALLSPFWNINAHSVVYITQGRARVQVVNNNGKTVFNGELRRGQLLIIPQHYAVVKKAQREGCAYIAFKTNPNSMVSHIAGKSSIFRALPNDVLANAYRISREEAQRLKHNRGDEFGAFTPIQYKSYQDVYNAAESS[SEQ ID 11]
区域：332至362-PRAGRVTNLNTQNFPILSLVQMSAVKVNLYQ[SEQ ID 43]
肽：VTNLNTQNFPILSLVQMSAVK[SEQ ID 133]
区域：375至406-HSVVYITQGRARVQVVNNNGKTVFNGELRRGQ[SEQ ID 44]
肽：ITQGRARVQVVNNNGKTVF[SEQ ID 134]
肽：ITQGRARVQVVNNNGKTVFNGE [SEQ ID 135]
肽：ITQGRARVQVVNNNGKTVFNG[SEQ ID 136]
肽：RVQVVNNNGKTVF[SEQ ID 137]
区域：440至471-HIAGKSSIFRALPNDVLANAYRISREEAQRLK[SEQ ID 45]
肽：RALPNDVLANAYRISREE[SEQ ID 138]
肽：SIFRALPNDVLANAYR[SEQID 139]
肽：SIFRALPNDVLANAY[SEQ ID 140]
肽：SIFRALPNDVLAN[SEQ ID 141]
肽：SSIFRALPNDVLANAYR[SEQ ID 142]
肽：SIFRALPNDVLANAYRISREE[SEQ ID 143]
肽：SIFRALPND[SEQ ID 144]
区域：180至208-VPVVAIYVTDLNNGANQLDPRQRDFLLAG[SEQ ID 46]
肽：IYVVTDLNNGANQLDPRQRD[SEQ ID 145]
大米蛋白质3：P07730-2-
MASINRPIVFFTVCLFLLCDGSLAQQLLGQSTSQWQSSRRGSPRGCRFDRLQAFEPIRSVRSQAGTTEFFDVSNELFQCTGVSVVRRVIEPRGLLLPHYTNGASLVYIIQGRGITGPTFPGCPETYQQQFQQSGQAQLTESQSQSHKFKDEHQKIHRFRQGDVIALPAGVAHWCYNDGEVPVVAIYVTDINNGANQLDPRQRDFLLAGNKRNPQAYRREVEEWSQNIFSGFSTELLSEAFGISNQVARQLQCQNDQRGEIVRVERGLSLLQPYASLQEQEQGQMQSREHYQEGGYQQSQYGSGCPNGLDETFCTMRVRQNIDNPNRADTYNPRAGRVTNLNSQNFPILNLVQMSAVKVNLYQNALLSPFWNINAHSIVYITQGRAQVQVVNNNGKTVFNGELRRGQLLIVPQHYVVVKKAQREGCAYIAFKTNPNSMVSHIAGKSSIFRALPTDVLANAYRISREEAQRLKHNRGDEFGAFTPLQYKSYQDVYNVAESS[SEQ ID 12]
区域：311至362-TFCTMRVRQNIDNPNRADTYNPRAGRVTNLNSQNFPILNLVQMSAVKVNLYQ[SEQ ID 47]
肽：VTNLNSQNFPILNLVQMSAVK[SEQ ID 146]
肽：QNIDNPNR[SEQ ID 147]
肽：ADTYNPR [SEQ ID 148]
肽：NIDNPNRADTYNPRAGRVTNL[SEQ ID149]
肽：RVRQNIDNPNRADTYNPRAGRVTNL[SEQ ID 150]
区域：427至499-
YIAFKTNPNSMVSHIAGKSSIFRALPTDVLANAYRISREEAQRLKHNRGDEFGAFTPLQYKSYQDVYNVAESS[SEQ ID 48]
肽：TNPNSMVSHIAGKSSIFR [SEQ ID 151]
肽：HNRGDEFGAFTPLQYK[SEQ ID 152]
肽：SYQDVYNVAESS[SEQ ID 153]
肽：ISREEAQR[SEQ ID 154]
肽：SIFRALPTDVLANAYRISREE[SEQ ID 155]
肽：YRISREEAQRLKHNRGDEF[SEQ ID 156]
肽：YRISREEAQRLKHNRGDE[SEQ ID 157]
区域：143至178-SQSHKFKDEHQKIHRFRQGDVIALPAGVAHWCYNDG[SEQ ID 49]
肽：FKDEHQKIHR[SEQ ID 158]
肽：QGDVIALPAGVAHW [SEQ ID 159]
区域：381至409-TQGRAQVQVVNNNGKTVFNGELRRGQLLI[SEQ ID 50]
肽：TVFNGELRR[SEQ ID 160]
肽：TVFNGELR[SEQ ID 161]
肽：QVQVVNNNGKTVF[SEQ ID 162]
区域：101至124-NGASLVYIIQGRGITGPTFPGCPE[SEQ ID 51]
肽：YIIQGRGITGPTF[SEQ ID 163]
肽：VYIIQGRGITGPTF[SEQ ID 164]
区域：46至66-CRFDRLQAFEPIRSVRSQAGT[SEQID 52]
肽：LQAFEPIRSVR[SEQ ID 165]
区域：253至292-QNDQRGEIVRVERGLSLLQPYASLQEQEQGQMQSREHYQE[SEQ ID 53]
肽：GLSLLQPYASLQEQEQGQMQSR[SEQ ID 166]
肽：GEIVRVER [SEQ ID 167]
肽：RGLSLLQPYASLQ [SEQ ID 168]
肽：RGLSLLQPYASLQEQ[SEQ ID 169]
肽：RGLSLLQPYASLQEQE[SEQ ID 170]
肽：RGLSLLQPYASLQE [SEQ ID 171]
区域：199至233-PRQRDFLLAGNKRNPQAYRREVEEWSQNIFSGFST[SEQ ID 54]
肽：RNPQAYR [SEQ ID 172]
肽：FLLAGNKRNPQAY[SEQ ID 173]
肽：EVEEWSQNIF[SEQ ID 174]
肽：LAGNKRNPQAYR[SEQ ID 175]
肽：FLLAGNKRNPQA[SEQ ID 176]
大米蛋白质4：Q0D7S0-3-
MASNKVVFSVLLLAVVSVLAATATMAEYHHQDQVVYTPGPLCQPGMGYPMYPLPRCRALVKRQCVGRGTAAAAEQVRRDCCRQLAAVDDSWCRCEAISHMLGGIYRELGAPDVGHPMSEVFRGCRRGDLERAAASLPAFCNVDIPNGGGGVCYWLARSGY[SEQ ID 13]
区域：102至124-GGIYRELGAPDVGHPMSEVFRGC[SEQ ID 55]
肽：ELGAPDVGHPMSE[SEQ ID 177]
大米蛋白质5：P14614-4-
MATIAFSRLSIYFCVLLLCHGSMAQLFGPNVNPWHNPRQGGFRECRFDRLQAFEPLRRVRSEAGVTEYFDEKNEQFQCTGTFVIRRVIEPQGLLVPRYSNTPGMVYIIQGRGSMGLTFPGCPATYQQQFQQFLPEGQSQSQKFRDEHQKIHQFRQGDIVALPAGVAHWFYNEGDAPVVALYVFDLNNNANQLEPRQKEFLLAGNNNREQQMYGRSIEQHSGQNIFSGFNNELLSEALGVNALVAKRLQGQNDQRGEIIRVKNGLKLLRPAFAQQQEQAQQQEQAQAQYQVQYSEEQQPSTRCNGLDENFCTIKARLNIENPSHADTYNPRAGRITRLNSQKFPILNLVQLSATRVNLYQNAILSPFWNVNAHSLVYIVQGHARVQVVSNLGKTVFNGVLRPGQLLIIPQHYVVLKKAEHEGCQYISFKTNANSMVSHLAGKNSIFRAMPVDVIANAYRISREQARSLKNNRGEELGAFTPRYQQQTYPGFSNESENEALE[SEQ ID 14]
区域：372至397-HSLVYIVQGHARVQVVSNLGKTVFNG[SEQ ID 56]
肽：IVQGHARVQVVSNLGK[SEQ ID 178]
肽：IVQGHARVQVVSNL[SEQ ID 179]
肽：IVQGHARVQVVSN[SEQ ID 180]
区域：464至486-ARSLKNNRGEELGAFTPRYQCQT[SEQ ID 57]
肽：NNRGEELGAFTPR[SEQ ID 181]
肽：GEELGAFTPR[SEQ ID 182]
区域：337至359-LNSQKFPILNLVQLSATRVNLYQ[SEQ ID 58]
肽：FPILNLVQLSATR[SEQ ID 183]
区域：210至293-
QMYGRSIEQHSGQNIFSGFNNELLSEALGVNALVAKRLQGQNDQRGEIIRVKNGLKLLRPAFAQQQEQAQQQEQAQAQYQVQYS[SEQ ID 59]
肽：SIEQHSGQNIFSGFNNELLSEALGVNALVAK[SEQ ID 184]
肽：LQGQNDQR[SEQ ID 185]
肽：SGFNNELLSEALGVNALVAK[SEQ ID 186]
肽：PAFAQQQEQAQQQEQAQAQY[SEQID187]
肽：VAKRLQGQNDQRGEI[SEQ ID 188]
肽：ALVAKRLQGQNDQRGEI[SEQID 189]
肽：LQGQNDQRGEIIRISEQ ID 190I
区域：24至47-AQLFGPNVNPWHNPRQGGFRECRF[SEQ ID 60]
肽：PNVNPWHNPRQGGF[SEQ ID 191]
区域：164至186-GVAHWFYNEGDAPVVALYVFDLN[SEQ ID 61]
肽：FYNEGDAPVVALY[SEQ ID 192]
肽：FYNEGDAPVV[SEQ ID 193]
肽：FYNEGDAPVVAL [SEQ ID 194]
肽：FYNEGDAPVVA[SEQ ID 195]
区域：424至463-YISFKTNANSMVSHLAGKNSIFRAMPVDVIANAYRISREQ[SEQ ID 62]
肽：TNANSMVSHLAGK [SEQ ID 196]
肽：AMPVDVIANAYR[SEQ ID 197]
大米蛋白质6：QODEV5-5-
MSALTTSQLATSATGFGIADRSAPSSLLRHGFQGLKPRSPAGGDATSLSVTTSARATPKQQRSVQRGSRRFPSVVVYATGAGMNVVFVGAEMAPWSKTGGLGDVLGGLPPAMAANGHRVMVISPRYDQYKDAWDTSVVAEIKVADRYERVRFFHCYKRGVDRVFIDHPSFLEKVWGKTGEKIYGPDTGVDYKDNQMRFSLLCQAALEAPRILNLNNNPYFKGTYGEDVVFVCNDWHTGPLASYLKNNYQPNGIYRNAKVAFCIHNISYQGRFAFEDYPELNLSERFRSSFDFIDGYDTPVEGRKINWMKAGILEADRVLTVSPYYAEELISGIARGCELDNIMRLTGITGIVNGMDVSEWDPSKDKYITAKYDATTAIEAKALNKEALQAEAGLPVDRKIPLIAFIGRLEEQKGPDVMAAAIPELMQEDVQIVLLGTGKKKFEKLLKSMEEKYPGKVRAVVKFNAPLAHLIMAGADVLAVPSRFEPCGLIQLQGMRYGTPCACASTGGLVDTVIEGKTGFHMGRLSVDCKVVEPSDVKKVAATLKRAIKVVGTPAYEEMVRNCMNQDLSWKGPAKNWENVLLGLGVAGSAPGIEGDEIAPLAKENVAAP[SEQ ID 15]
区域：571至608-KGPAKNWENVLLGLGVAGSAPGIEGDEIAPLAKENVAA[SEQ ID 63]
肽：NWENVLLGLGVAGSAPGIEGDEIAPLAK [SEQ ID 198]
肽：NVLLGLGVAGSAPGIEGDE[SEQ ID 199]
肽：NWENVLLGLGVAGSAPGIEGDEIAPLAK[SEQ ID 200]
区域：458至488-RAVVKFNAPLAHuMAGADVLAVPSRFEPCG[SEQ ID 64]
肽：FNAPLAHLIMAGADVLAVPSR[SEQ ID 201]
肽：FNAPLAHLIM[SEQ ID 202]
肽：FNAPLAHLIMAGADVLAVPSR[SEQ ID 203]
区域：545至566-KRAIKVVGTPAYEEMVRNCMNQ[SEQ ID 65]
肽：VVGTPAYEEMVR[SEQ ID 204]
区域：93至147-APWSKTGGLGDVLGGLPPAMAANGHRVMVISPRYDQYKDAWDTSVVAEIKVADRY[SEQ ID 66]
肽：TGGLGDVLGGLPPAMAANGHR[SEQ ID 205]
肽：YDQYKDAWDTSVVAEIK[SEQ ID 206]
肽：DAWDTSVVAEIK[SEQ ID 207]
肽：VMVISPR[SEQ ID 208]
区域：305至413-
INWMKAGILEADRVLTVSPYYAEELISGIARGCELDNIMRLTGITGIVNGMDVSEWDPSKDKYITAKYDATTAIEAKALNKEALQAEAGLPVDRKIPLIAFIGRLEEQK[SEQ ID 67]
肽：LTGITGIVNGMDVSEWDPSKDK[SEQ ID 209]
肽：VLTVSPYYAEELISGIAR[SEQ ID 210]
肽：EALQAEAGLPVDRK[SEQ ID 211]
肽：YDATTAIEAK[SEQ ID 212]
肽：IPLIAFIGR[SEQ ID 213]
肽：AGILEADR[SEQ ID 214]
肽：IPLIAFIGR[SEQ ID 215]
区域：158至202-RGVDRVFIDHPSFLEKVWGKTGEKIYGPDTGVDYKDNQMRFSLLC[SEQ ID68]
肽：VFIDHPSFLEK[SEQ ID 216]
肽：GPDTGVDYKDNQM[SEQ ID 217]
肽：IYGPDTGVDYKDNQMR[SEQ ID 218]
肽：IYGPDTGVDYK[SEQ ID 219]
区域：206至226-LEAPRILNLNNNPYFKGTYGE[SEQ ID 69]
肽：ILNLNNNPYFK[SEQ ID 220]
蛋白质P02855
肽：KNPQLQDLDI[SEQ ID 356]
蛋白质P07730
肽：GQSTSQVVQSSR[SEQ ID 357]
肽：QSTSQWQSSR[SEQ ID 358]
蛋白质P07728
肽：QSTSQWQSSR(也在P07730中)[SEQ ID 359]
蛋白质P13918
肽：EEEEQGEEEINK[SEQ ID 360]
蛋白质P14323
肽：PSTNPWHSPR[SEQ ID 361]
肽：AQAQDQYQQVQYSE[SEQ ID 362]
肽：SEAGVTEYFDEKNELFQCTGTFVIRR[SEQ ID 363]
肽：QAQAQDQYQQVQYSE[SEQ ID 363]
肽：GSMGLTFPGCPAT(也在P14614中)[SEQ ID 365]
肽：GSMGLTFPGCPATY(也在P14614中)[SEQ ID 366]
蛋白质P14614
肽：LGAFTPRY[SEQ ID 367]
肽：LGAFTPRYQQ[SEQ ID 368]
肽：ALGVNALVAKRLQGQN[SEQ ID 369]
肽：LGAFTPRYQ[SEQ ID 370]
肽：GSMGLTFPGCPAT(也在P14323中)[SEQ ID 371]
肽：GSMGLTFPGCPATY(也在P14323中)[SEQ ID 372]
蛋白质P15838
肽：SNNPFKFLVPARQS[SEQ ID 373]
蛋白质Q6K508
肽：CAGVFVIRR[SEQ ID 374]
蛋白质Q6K7K6
肽：GSPLQSPRGF[SEQ ID 375]
肽：RSSWQQQSY[SEQ ID 376]
肽：SFGGSPLQSPR[SEQ ID 377]
肽：YLPTKQLQPTW[SEQ ID 378]
肽：GKPRSSWQQQ[SEQ ID 379]
肽：FGGSPLQSPRG[SEQ ID 380]
蛋白质Q9M3X6
肽：LNLLGFGINAENNE[SEQ ID 381]
额外的肽[SEQ ID 381-417]
LRGFSK[381]
GALMLPHYN
GALMLPHYNSR
VFDGVLRPG
LQSQND
LQSQNDQRGEI
QSQNDQRGEIIHVK
RGEIIHVK
RLQSQNDQ
RLQSQNDQRG[SEQ ID 390]
RLQSQNDQRGEIIH
MPMP
PMPL
LEPDNR
GIARLAGTSSVIN
RSQNIF
PNSM
GHPM
HPMS
FLPQHTD[SEQ ID 400]
EWQINEK
GPQQYAEWQINEK
PQQYAEWQ
RGPQQYA
HNPR
WHN
WDP
HPSF
PGQLQSFLLSGNQNQQNYLSGF
QLQSFLLSGNQNQQNYLSGFSK[SEQ ID 410]
QSFLLSGNQNQQ
PGQLQSFLLSGN
QSFLLSGNQ
QNQQNYLSGFSK
YLRGF5
PVEMPTLLYP5
RGPQQYAEWQINE[SEQ ID 417]
TVFDGVLRPGQL
LDALEPDNR
RLQSQNDQRGEIIHVK[SEQ ID 420]
VLDLAIPVNRPGQL
HGPVEMPYTLLYPSSK[SEQ ID 422]
GYYGEQQQQPGMTR[SEQ ID 423]蛋白质：P29835-5-大米
SEEGYYGEQQQQPGMTR[SEQ ID 424]蛋白质：P29835-5-大米
蛋白质：P29835-5-大米
MASKVVFFAAALMAAMVAISGAQLSESEMRFRDRQCQREVQDSPLDACRQVLDRQLTGRERFQPMFRRPGALGLRMQCCQQLQDVSRECRCAAIRRMVRSYEESMPMPLEQGWSSSSSEYYGGEGSSSEQGYYGEGSSEEGYYGEQQQQPGMTRVRLTRARQYAAQLPSMCRVEPQQCSIFAAGQY[SEQ ID 353]
蛋白质：P02857-1-豌豆(Pea)
MAKLLALSLSFCFLLLGGCFALREQPQQNECQLERLDALEPDNRIESEGGLIETWNPNNKQFRCAGVALSRATLQRNALRRPYYSNAPQEIFIQQGNGYFGMVFPGCPETFEEPQESEQGEGRRYRDRHQKVNRFREGDIIAVPTGIVFWMYNDQDTPVIAVSLTDIRSSNNQLDQMPRRFYLAGNHEQEFLQYQHQQGGKQEQENEGNNIFSGFKRDYLEDAFNVNRHIVDRLQGRNEDEEKGAIVKVKGGLSIISPPEKQARHQRGSRQEEDEDEEKQPRHQRGSRQEEEEDEDEERQPRHQRRRGEEEEEDKKERGGSQKGKSRRQGDNGLEETVCTAKLRLNIGPSSSPDIYNPEAGRIKTVTSLDLPVLRWLKLSAEHGSLHKNAMFVPHYNLNANSIIYALKGRARLQVVNCNGNTVFDGELEAGRALTVPQNYAVAAKSLSDRFSYVAFKTNDRAGIARLAGTSSVINNLPLDVVAATFNLQRNEARQLKSNNPFKFLVPARESENRASA[SEQ ID354]
蛋白质：P09918-14-豌豆(Pisum sativum)
MFSGVTGILNRGHKIKGTVVLMRKNVLDINSLTTVGGVIGQGFDILGSTVDNLTAFLGRSVSLQLISATKPDATGKGKLGKATFLEGIISSLPTLGAGQSAFKIHFEWDDDMGIPGAFYIKNFMQTEFFLVSLTLDDIPNHGSIYFVCNSWIYNAKHHKIDRIFFANQTYLPSETPAPLVHYREEELNNLRGDGTGERKEWERIYDYDVYNDLGNPDSGENHARPVLGGSETYPYPRRGRTGRKPTRKDPNSESRSDYVYLPRDEAFGHLKSSDFLTYGLKAVSQNVVPALESVFFDLNFTPNEFDSFDEVHGLYEGGIKLPTNILSQISPLPVLKEIFRTDGENTLKYPPPKVIQVSRSGWMTDEEFAREMLAGVNPNVICCLQEFPPRSKLDSQIYGDHTSKISKEHLEPNLEGLTVEEAIQNKKLFLLDHHDSIMPYLRRINSTSTKAYATRTILFLNNNQNLKPLAIELSLPHPQGDEHGAVSYVYQPALEGVESSIWLLAKAYVIVNDSCYHQLVSHWLNTHAVVEPFVIATNRHLSCLHPIYKLLYPHYRDTMNINSLARLSLVNDGGIIEKTFLWGRYSMEMSSKVYKNWVFTEQALPADLIKRGMAIEDPSSPCGVKLVVEDYPYAVDGLEIWAIIKTWVQDYVSLYYTSDEKLRQDSELQAWWKELVEVGHGDKKNEPWWPKMQTREDLIEVCSIVIWTASALHAAVNFGQYSYGGLILNRPTLSRRFMPEKGSAEFEELVKSPQKAYLKTITPKFQTLIDLSVIEILSRHASDELYLGERDNPNWTSDKRALEAFKKFGNKLAEIEKKLTQRNNDEKLRNRHGPVEMPYTLLYPSSKEGLTFRGIPNSISI[SEQ ID 355]
细菌蛋白质1：P0C1U8-5-
MKGKFLKVSSLFVATLTATLVSSPAANALSSKAMDNHPQQTQSSKQQTPKIQKGGNLKPLEQREHANVILPNNDRHQITDTTNGHYAPVTYIQVEAPTGTFIASGVVVGKDTLLTNKHVVDATHGDPHALKAFPSAINQDNYPNGGFTAEQITKYSGEGDLAIVKFSPNEQNKHIGEVVKPATMSNNAETQVNQNITVTGYPGDKPVATMWESKGKITYLKGEAMQYDLSTTGGNSGSPVFNEKNEVIGIHWGGVPNEFNGAVFINENVRNFLKQNIEDIHFANDDQPNNPDNPDNPNNPDNPNNPDEPNNPDNPNNPDNPDNGDNNNSDNPDAA[SEQ ID 16]
区域：92至117-YIQVEAPTGTFIASGVVVGKDTLLTN[SEQ ID 70]
肽：APTGTFIASGVVVGKD[SEQ ID 221]
豌豆蛋白质1(SEQ ID 1)的同源物
＞gi|137584|sp|P08438.1IVCL_VICFA RecName：完整＝豌豆球蛋白：标志：前体[蚕豆]＞gi|22057|emb|CAA68559.1|
豌豆球蛋白[小蚕豆]＞gi|383931031|gb|AFH56916.1I豌豆球蛋白[蚕豆]
MAATTLKDSFPLLTLLGIAFLASVCLSSRSDQDNPFVFESNRFQTLFENENGHIRLLQKFDQHSKLLENLQNYRLLEYKSKPHTIFLPQQTDADFILVVLSGKAILTVLLPNDRNSFSLERGDTIKLPAGTIGYLVNRDDEEDLRVLDLVIPVNRPGEPQSFLLSGNQNQPSILSGFSKNILEASFNTDYKEIEKVLLEEHGKEKYHRRGLKDRRQRGQEENVIVKISRKQIEELNKNAKSSSKKSTSSESEPFNLRSREPIYSNKFGKFFEITPKRNPQLQDLNIFVNYVEINEGSLLLPHYNSRAIVIVTVNEGKGDFELVGQRNENQQGLREEYDEEKEQGEEEIRKQVQNYKAKLSPGDVLVIPAGYPVAIKAS5NLNLVGFGINAENNQRYFLAGEEDNVISQIHKPVKELAFPGSAQEVDTLLENQKQSHFANAQPRERERGSQEIKDHLYSILGSF[SEQ ID 222]
＞gi|502105533|ref|XP_004492829.1|预测的：豌豆球蛋白样亚型X1[鹰嘴豆(cicer arietinum)]鹰嘴豆(ChickPea)
MAIKARFPLLVLLGIVFLASVCAKSDKENPFFFKSNNCQTLFENENGHVRLLQRFDKRSQLFENLQNYRLMEYNSKPHTLFLPQHNDADFILVVLRGRAILTVLNPNDRNTFKLERGDTIKLPAGTIAYLANRDDNEDLRVLDLAIPVNRPGQFQSFSLSGNENQQSYFQGFSKKILEASFNSDYEEIERVLLEEQEQKPEQRRGHKGRQQSQETDVIVKISREQIEELSKNAKSNCKKSVSSESEPFNLRSRSPIYSNRFGNFFEITPEKNPQLKDLDIFVNSVEIKEGSLLLPHFNSRATVILVVNEGKGEVELVGLRNENEQENKKEDEEEEEDRNVQVQRFQSKLSSGDVVVIPASHPFSINASSDLFLLGFGINAQNNQRNFLAGEEDNVISQIQRPVKEVAFPGSAEEVDRLLKNQRQSHFANAQPQQKRKGSQRIRSPF[SEQ ID 223]
＞gi|29539109|emb|CAD87730.1|过敏原Len c1.0101[兵豆(Lens culinaris)]小扁豆(Lentil)
SRSDQENPFIFKSNRFQTIYENENGHIRLLQRFDKRSKIFENLQNYRLLEYKSKPHTIFLPQFTDADFILVVLSGKAILTVLNSNDRNSFNLERGDTIKLPAGTIAYLANRDDNEDLRVLDLAIPVNRPGQLQSFLLSGTQNQPSFLSGFSKNILEAAFNTEYEEIEKVLLEEQEQKSQHRRSLRDKRQEITNEDVIVKVSREQIEELSKNAKSSSKKSVSSESEPFNLRSRNPIYSNKFGKFFEITPEKNPQLQDLDIFVNSVEIKEGSLLLPNYNSRAIVIVTVNEGKGDFELVGQRNENQQEQREENDEEEGQEEETTKQVQRYRARLSPGDVLVIPAGHPVAINASSDLNLIGFGINAKNNQRNFLAGEEDNVISQIQRPVKELAFPGSSREVDRLLTNQKQSHFANAQPLQIE[SEQ ID 224]
豌豆蛋白质2(SEQ ID 2)的同源物
＞gi|29539111|emb|CAD87731.1|过敏原Lenc1.0102[兵豆]
SRSDQENPFIFKSNRFQTIYENENGHIRLLQKFDKRSKIFENLQNYRLLEYKSKPHTLFLPQYTDADFILVVLSGKAVLTVLNSNDRNSFNLERGDTIKLPAGTIAYLANRDDNEDLRVLDLAIPVNNPGQLESFLLSGTQNQPSFLSGFNKSILEAAFNTDYEEIEKVLLEDQEQEPQHRRSLRDRRQEINKENVIVKVSREQIKELSKNAKSSSKKSVSSESEPFNLRSRNPIYSNKFGKFFEITPEKNPQLQDLDIFVNSVEIKEGSLLLPNYNSRAIVIVTVNEGKGYFELVGQRNENQREENDDEEEQEEETSTQVQRYRAKLSPGDVFVVPAGHPVAINASSDLNLIGFGINAKNNQRNFLAGEEDNVISQIQRPVKELAFPGSSREVDRLLTNQKQSHFANAQPLQIE[SEQ ID 225]
＞gi|1297072|emb|CAA96514.1|豌豆球蛋白前体[法国野豌豆]
MAAITMKVSFPLLMLLGISFLASVCVSSRSDQENPFIFKSNKFQTLFENDNGHIRLLQKFDERSKILENLQNYRLLEYKSKPRTIFLPQQTNADFILVVLSGSKAILIVLKPDDRNSFNLERGDTIKLPAGTIAYLVNKDDNEDLRVLDLAIPVNGPDQLQSFLLSGSENQQSILSGFSKSVLEASFNTGYEEIEKVLLEEREKETQHRRSLRDKRQHSQDEDVIVKLSRGQIEELSRNAKSSSKKSVSSESEPFNLRSRNPIYSNKFGKFFEITPEKNPQLQDLDVLVNSVEIKEGSLLLPHYNSRAIVIVTVNDGKGDFEIVGQRNENRQGQRKEDDEEEEQGDENTNTQVQNYKAKLSRGDVFVIPAGHPVSIKASSNLDLLGFGINAKNNQRNFLAGEEDNVISQIDRPVKELAFPGSAQEVDRLLENQKQSHFANAQPQQRERGSHETRDHLSSILDAF[SEQ ID 226]
＞gi|28629838|gb|AAO4S103.1|β-伴大豆球蛋白α’亚基[大豆(Glycine max)]
QYGHVRVLQRFNKRSQQLQNLRDYRILEFNSKPNTLLLPHHADADYLIVILNGTAILTLVNNDDRDSYNLQSGDALRVPAGTTYYVVNPDNDENLRMITLAIPVNKPGRFESFFLSSTQAQQSYLQGFSKNILEASYDTKFEEINKVLFGREEGQQQGEERLQESVIVEISKKQIRELSKHAKSSSRKTISSEDKPFNLRSRDPIYSNKLGKLFEITPEKNPQLRDLDVFLSVVDMNEGALFLPHFNSKAIVVLVINEGEANIELVGIKEQQQRQQQEEQPLEVRKYRAELSEQDIFVIPAGYPVVVNATSDLNFFAFGINAENNQRNFLAGSKDNVISQIPSQVQELAFPGSAKDIENLIKSQSESYFVDAQPQQKEEGNKGRKGPLSSILRAFY[SEQ ID 227]
豌豆蛋白质3(SEQ ID 3)的同源物
＞gi|483449|emb|CAA83677.1|豆球蛋白A[箭筈豌豆(Vicia sativa)]
MAKLLALSLSFCFLLFSSCFALREQSQQNECQLERINALEPDNRIESEGGLIETWNPNNRQFRCARVALSRATLQRNALRRPYYSNAPQEIYIQQGNGYFGMVFPGCPETHEEPQQSEQGEGRRYRDSHQKVNRFREGDIIAVPTGIAFWMYNDQDTPVIAISLTDTGSSNNQLDQMPRRFYLAGNQEQEFLRYQHQQGGKQEQDNDGNNIFSGFKRDFLEDAFNVNRHIVDRLQGRNEDEEKGAIVKVKGGLSIIAPPERQARHERGSRQEEDEDEKEERQPSHHKSRRDEDEDDKEKRHSQKGQSRRQGDNGLEETVCTAKLRANIGSSPSPDIYNPQAGRIKTVTSLDLPVLRWLKLSAEHGSLHKNAMFVPHYNLNANSVIYALKGRARLQVVNCNGNTVFDGELEAGRALTVPQNYAVAAKSLSERFTYVAFKTDDRASIARLAGTSSVIDDLPLDVVAATFNMQRNEARQLKSNNPFKFLVPPRQSEMRASA[SEQ ID 228]
＞gi|657379551|gb|KEH23931.1|豆球蛋白A2[蒺藜苜蓿(Vedicagotruncatula)]
MAKLLALSLSLCFLLFSGCFAIREHQPHQKQQPQQNECQLEQLNALEPDNRIESEGGIIETWNPNNRQFRCAGVALSRCTLQRNSLRRPFYSNAPQEIFIQQGSGYFGMVFPGCPETFEEPQESEQRESRRIRESEQGESRRIRESEQGEGRRFRDSHQKVNRFREGDLIAVPTGTVFWMYNDQDTPVIAVSLIDTGSFQNQLDEMPRRFYLAGNQEQEFLQYQQQQVRGRGEQRRGREQQENEGGNIFSGFKRDFLEDALNVNRHIVDRLQGRNEDEEKGAIVKVRGGLSFVTPPERQSRHQGGSIIEEDEDEEDEWRRPHHQKSRRGEEEERPCRRGQKCERSNGLEETICTARLRQNIGSSSSPDIYNPEAGRIKTVTSFDLPALRWLRLSAEHGTLHRNAMFVPHYNLNANSAIYALRGRARLQVVNCNGNTVFDGELEAGRVLIVPQNFAVAAKSMSDRFQYVSFKTNDNAAIARLAGTQSTLSGVPMDVLAATYNMDRNEARQLKNNNLYKFLVPPRESERRAAA[SEQ ID 229]
＞gi|206712292|emb|CAR78996.1|豆球蛋白贮藏蛋白质5[百脉根]
MAYKLFALSLSFCFLLFGGCFAIRQQSQQQNECQLERLNALKPDNRIESEAGYIETWNPTNNQFRCAGVALSRCTLRRNGLKRPSYSNAPQEIFIQQGSGIFGMIFPGCPETVEEPFESDQQGRRDRHQKVNRFREGDVIAVPPGVVFWMYNEEETPVIAVSLIDTGSYLNQLDQMPRRFYLSGNQEQEFLQYQRQEVRGREEENQGGNIFSGFGGEFLEDALNIDRNIVHKLQGRDEEQDKGAIVRVKGGLSVIIPPERQSHRRGSEEEEDEEEDRPSRHQSRGGSRRNGLEETICTVRLRMNIGKSSSPDIFNPQAGRIKTATGFDFPALRFLKLSAEHGSLNRNAMVVPHYNLNANSIIYALRGRAWIQVVNCKGNRIFDGELEEGQVLIVPQNFVVAARSMSDKFNYVAFKTNDMPTMAKLAGATSEIQAMPLEVIQNAFNLEREQAKQVKFNNRFNFLVPPREQSQRRASA[SEQ ID 230]
豌豆蛋白质4(SEQ ID 4)的同源物
＞gi|164512526IembICAP06312.1I cvc[埃塞俄比亚豌豆(Pisum abyssinicum)]
MATTVESRFPLLLFPGIIFLASVCVTYANYDEGSETRVPGQRERGRQEGEKEEKRHGEWRPSYEKEEDEEEKQKYRYQREKEDEEEKQKYRYQREKKEEKEVQPGRERWEREEDEEQVDEEWRGSQRRQDPEERARLRHREERTKRDRRHKREGEEEERSSESQEQRNPFLFKSNKFLTLFENENGHIRRLQRFDKRSDLFENLQNYRLVEYRAKPHTIFLPQHIDADLILVVLNGKAILTVLSPNDRNSYNLERGDTIKIPAGTTSYLVNQDDEEDLRVVDFVIPVNRPGKFEAFGLSENKNQYLRGFSKNILEASLNTKYETIEKVLLEEQEKKPQQLRDRKRRQQGGERDAIIKVSREQIEELRKLAKSSSKKSLPSEFEPFNLRSHKPEYSNKFGKLFEITPEKKYPQLQDLDILVSCVEINKGALMLPHYNSRAIVVLLVNEGKGNLELLGLKNEQQEREDRKERNNEVQRYEARLSPGDVVIIPAGHPVAISASSNLNLLGFGTNAENNQRNFLSGSDDN[SEQ ID 231]
＞gi|164512538|emb|CAP06318.1| cVc[山黧豆葵(Lathyrus annuus)]
MATTIKSRFPLLLLLGIIFLASVCVTWANYDEGSEPRVPGQRERGRQEGEKEEKRHGEWRPSYEEEYDEGLEPKVPGKRERGRQEGEKEEKRHEEWRPSYEKEEDEEEKQKYNYQREKKEHKEVQPGRERWERKQDEKQVEEDEEPGEEQWRGSKRHEDPEERARLRHREEKTKSYVEDNEETSSKEGRNPFLFKSNKFLTLFENENGHIRRLQRFDERSDIFENLQNYRLVEYRAKPHTMFLPQHIDADLILVVLNGKAILTVLSPNDRNSYNLERGDTVKLPAGTTSYLVNQDDEEDLRVVDLAIPVNRPGKFEAFGLSANKNQYLRGFSKNILEASLNTKYETIEKVLLEERRDQKGRQQGQETNAIVKVSREQIEELRKLAKSSSKKSLLSESEPLNLRSQNPKYSNKFGKFFEITPQKKYPQLQDLDVSISCVEINKGALLLPHYNSRSIGILLVNEGKGNLELVGFKNEQQRQRENEETNKKLQRYEARLSSGDVVVIPEGHPVAISASSNLNLLGFGINAANNQRNFLTGSDDN[SEQ ID 232]
＞gi|164512558|emb|CAP06328.1|cvc长柔野豌豆
MATTIKSRFPVLLLLGIIFLTSVCVTYANYDEGREPSVPGQRERGRQEGEKEEKRHGEWRPSEEDEEEKYKYEEGRVPGQRERGRQEGEKEEKRHGKWRPSEEEDEEEKYRYEEGSEPRGPGQRETGRQEGEKEKQRPEREPSYEKEEDEEEKQKYQYHREKKEQREVRPGRERFERHEDEEQWRGIQRHEDPEERARERYRAEIAKRQVEEEREERDIPHEREQRNPFLFKSNKFQTLFQNENGYIRRLQRFDKRSDLFENLQNYRLVEYRAKPHTIFLPQHIDADLIIVVLSGRAILTVLSPDDRNSYNLERGDTIKLPAGTTSYLVNQDDEEDLRVVDLAIPVNRPGKVESFLLSGNKNQYLRGFSKNILEASFNTNYETIERVLLEEQDKESQQSIGQKRRSQRQETNALVKVSREQLEDLKRLAKSSSQEGLSSQFEPINLRSQNPKYSNKFGKVFEITPEKKYPQLQDLDLFVSSVDIKEGALMLPHYNSRAIVVLLVNEGRGNLELVGLKNEQQEQREKEDEQQERNNQVQRYEARLSPGDVVIIPAGHPVAVRASSDLNLLAFGINAENNQRNFLAGSDDN[SEQ ID 233]
豌豆蛋白质5(SEQ ID 5)的同源物
＞gi|357507721IrefIXP_003624149.1|前豌豆球蛋白(provicilin)[蒺藜苜蓿]＞gi|87162569lgbIABD28364.1|Cupin，RmIC-型
[蒺藜苜蓿]＞gi|355499164|gb|AES80367.1|豌豆球蛋白47kDa蛋白质[蒺藜苜蓿]
MAIKAPFQLLMLLGIFFLASVCVSSRDDRHDQENPFFFNANHFQTLFENENGHIRLLQRFDKRSKIFENLQNYRLLEYHSKPHTLFLPQHNDADFILAVLSGKAILTVLNPDNRNSFNLERGDTIKLPAGSIAYLANRDDNEDLRVLDLAIPVNRPGKFQSFSLSGSQNQQSFFSGFSKNILEAAFNANYEEIERVLIEEHEQEPQHRRGLRKDRRQQSQDSNVIVKVSREQIEELSRHAKSSSRRSGSSESAPFNLRSREPIYSNEFGNFFEITPEKNPQLKDLDILVNYAEIREGSLLLPHFNSRATVIVVVDEGKGEFELVGQRNENQQEQREEDEQQEEERSQQVQRYRARLSPGDVYVIPAGHPTVVSASSDLSLLGFGINAENNERNFLAGEEDNVISQIERPVKEVAFPGSAQDVESLLKNQRQSYFANAQPQQREREEGRSQRQRELISSILGVF[SEQ ID 234]
＞gi|164512560|emb|CAP06329.1|共豌豆球蛋白(convicilin)[游隼野豌豆(Vicia peregrine)]
MATTFKSRFSLLLLLGIIFLAFVCVTCANYDEGSEPRVPGQRERGRQEGEKEEQSRERHPQREPSREKEEDEEEKQKYDEGTEPRVPGQRERGRQEGEKEEQRRERHPGQREPSQEEDEEREESDRRQEGSSKSEEQRNPFLFKSNKFLTLFQNGNGHIRLLQRFDKRSDLFENLQNYRLLEYRAKPHTIFLPQHIDADLILVVLSGRAILTVLSPDDRNSYNLERGDTIKLPAGTTSYPLNQDDEEDLRVVDLAISVNRPGKVESFNLSGNKNQYLRGFSENILEASFNTKYETIEKVLLEEQDKESQQPRGQRLQRQETNALVKVSREQVEELKRLARTSSKKGVSSEFEPFNLRSHGPKYSNKFGKFFEITPEKKYPQLQDLDISVSSVEINEGALFLPHYNSRAIVVVLVDEGKGNLELVGFKNEQQEQREKEDEQEERNKQVQRYEAKLSPGDVVIIPAGHPVAVSASSNLNLLGFGINAENNQRNFLTGSDDN[SEQ ID 235]
＞gi|164512562|emb|CAP06330.1|共豌豆球蛋白[黄花豌豆(Vicia lutea)]
MATTFIKLRFPLLLLLGVILLASVCVTCANYDEGSEPRVPGRPEGEKEEKHRGKLRPSYEKEEDEGEKQRYHYEKKEQKEAQPRREKKEQKEEEKQVEEESRESQRYEDPGERARERYRAEIIKRQVEKEREERDRRHQREGEEEEGSSKSRNPFLFKSNNFLTLFENENGHIRLLQRFDKRSDLFENLQNYRLVEYRAKPHTIFLPQHIDADLILVVLSGKAILTVLSPNNRNSYNLKRGDTIKLPAGTTSYLLNSDDEEDLRMVDLAISVNRPGKVESFNLSGNKNQYLRGFSKNILEASFNTKYETIEKVLLEEQDKESQQSIGQKRISQRQETNALVKVSREQIEEPKRLARSSSRKGVSSEFEPINLRSQRPKYSNKFGKFYEISPEKKYPQLQDLDVSVSSVEINEGALLLPHYNSRAIVTVLVNEGKGNLELIGFQNEQQGQREKEDEQQHERNKQVQRYDARLSSGDVVIIPAGHPVAVSASSNLDLLGFGINAENSQRNFLTGSDDN[SEQ ID236]
大米蛋白质1(SEQ ID 6)的同源物
＞gi|573919041|ref|XP_006647142.1|预测的：谷蛋白型-B4-样[短花药野生稻]
MATTTFSRFSIYFCVLLLCHGSMAQLFSPTLNPWHSSRRGGSRDCRFDRLQAFEPLRRVRSEAGVTEYFDERNEQFQCTGTFVIRRVIEPQGLLVPRYTNTPGVVYIMQGRGSMGLTFPGCPATYQQQFQQFLPEGQSQSQKFRDEHQKIHQFRQGDIVALPAGVAHWFYNEGDTPVVALYVFDINNSANQLEPRQKDFLLAGNNNREQQVYGRSIEKHSGQNIFSGFNHELLSEALGISTLAAKRLQGQNDHRGEIIRVRNGLQLLKPTFTQQQEQAQSQYQVQYSEKQQESTRCNGLDENFCTINARLNIENPSRADTYNPRAGRITHLNNQKFPILNLVQMSATRVNLYQNAILSPYWNVNAHSLVYMVQGHARVQVVSNLGKTVFNSVLRPGQLLIIPQHYVVLKKAEREGCQYIAFKTNANSIVSQLAGKNSILRAMPVDVVANAYRISREQARDLKNNRGEELGAFTPKFEQQSYPGLSNESESEASE[SEQ ID 237]
＞gi|2764800|emb|CAA54153.1| 12s球蛋白[燕麦]
MATTSFPSVLFYSCIFLLYNGSMAQLFGQSFTPWQSSRQGGLKGCKFDRLQAFEPLRQVRSQAGVTEYFDEQNEQFRCTGVFVIRRVIEPQGLLLPQYHNAPGLVYILQGRGYTGLTFPGCPATFQQQFQPFDQAQDQSQSHLKDEHQRVHRFKQGDVIALPAGIVHWGYNDGDAPVVAIYVFDVNNNANQLEPRQKEFLLAGNNKEDQQFGQNIFSGFNIQLLSEALGISQQAAQRIQSQKEQRGEIIRVTQALQFLKPTMSQQELVEHQAYQPIQSQEGQSTQYQVGQSTQYQEGQSTQYQAGQSQDRSFNGLEENFCSLEARQNIGNPKRADTHNPRAGRITRLHGQNFPILNLVQMSATRVNLYQNAILSPFWNINAHSVVYMIQGHAQVQVVNNNGQTVFNDRLRQGQLLIVPQHYVVLKKAEREGCQYISFKTNPNSMVSHIAGKSSILRALPVDVLANAYRISRQEARNLKNNRGQESGVFTPKFTQTSFQPYPEGEDESSLTNKASE[SEQ ID238]
＞gi|357130026|ref|XP_003566659.1|预测的：12S种子贮藏球蛋白1-样[二穗短柄草]
＞gi|357130028|ref|XP_003566660.1|预测的：12S种子贮藏球蛋白1-样[二穗短柄草]
MAHTSFSSVLSYFCIFLLFHGSMAQVPGQGSTWQSPRQGGSRECSFDRLQTIEPLTQVRSQAGLTEYFDEQNEQFRCAGVSVIRRVIEPRGLLLPRYHNTPGLVYILEGSGFVGLAFPGCPETFLEQFQQSRQTQSTLGQSQCQSQSQKLGDVHQRVHQFTQGDVVALPAGVAHWFYNGGDAPVVAVYVFDVNNNANQLEPRQKEFLLAGNYNGVLQSGRNILNGLNAQLLSQAFGINEQTSRIIQNQNDGRGEIVRVEYGLQFLTPVVTQQQQKQPFLPIEPQEGQSSRNGLEENFCSLEPRQNIEDPNRADTYNPRAGSIARLNGQNFPILNLVQMSATRVNLQKNAIVSPFWNINAHSVVYVIQGQASVQVVNNQGRNVFNGLLRRGQLLIIPQNYVVLKKAESEGYQYIAFKTNANSMVSHIAGKNSILRALPVDVIANAYRISRQEAQNLKNNRGEEIGVLTPNFPQSSCQSYPIGDVDSSSTPKAQE[SEQ ID 239]
大米蛋白质2(SEQ ID 7)的同源物
＞gi|222622792|gb|EEE56924.1|假定蛋白质OsJ_06602[粳稻组水稻]
MAQFSFGGSPLQSPRGFRGDQDSRHQCRFEHLTALEATHQQRSEAGFTEYYNIEARNEFRCAGVSVRRLVVESKGLVLPMYANAHKLVYIVQGRGVFGMALPGCPETFQSVRSPFEQEVATAGEAQSSIQKMRDEHQQLHQFHQGDVIAVPAGVAHWLYNNGDSPVVAFTVIDTSNNANQLDPKRREFFLAGKPRSSWQQQSYSYQTEQLSRNQNIFAGFSPDLLSEALSVSKQTVLRLQGLSDPRGAIIRVENGLQALQPSLQVEPVKEEQTQAYLPTKQLQPTWLRSGGACGQQNVLDEIMCAFKLRKNIDNPQSSDIFNPHGGRITRANSQNFPILNIIQMSATRIVLQNNALLTPHWTVNAHTVMYVTAGQGHIQVVDHRGRSVFDGELHQQQILLIPQNFAVVVKARREGFAWVSFKTNHNAVDSQIAGKASILRALPVDVVANAYRLSREDSRHVKFNRGDEMAVFAPRRGPQQYAEWQINEK[SEQ ID 240]
＞gi|218190679|gb|EEC73106.1|假定蛋白质OsI_07091[籼稻组水稻]
MAQFSFGGSPLQSPRGFRGDQDSRHQCRFEHLTALEATHQQRSEAGFTEYYNIEARNEFRCAGVSVRRLVVESKGLVLPMYANAHKLVYIVQGRGVFGMALPGCPETFQSVRSPFEQEVATAGEAQSSMQKMRDEHQQLHQFHQGDVIAVPAGVAHWLYNNGDSPVVAFTVIDTSNNANQLDPKRREFFLAGKPRSSWQQQSYSYQTEQLSRNQNIFAGFNPDLLSEALSVSKQTVLRLQGLSDPRGAIIRVENGLQALQPSLQVEPVKEEQTQAYLPTKQLQPTWSRSGGACGQQNGLDEIMCAFKLRKNIDNPQSSDIFNPHGGRITRANSQNFPILNIIQMSATRIVLQNNALLTPHWTVNAHTVMYVTAGQGRIQVVDHRGRSVFDGELHQQQILLIPQNFAVVVKARREGFAWVSFKTNHNAVDSQIAGKASILRALPVDVVANAYRLSREDSRRVKFNRGDEMAVFAPRRGPQQYAEWQINEK[SEQ ID 241]
＞gi|573922051|ref|XP_006648611.1|预测的：谷蛋白型-A1样[短花药野生稻]
MVDMSIVVPVCLTIFLLSQVCIAQVSFDGSPLYSSRGFRGGSASQQQCRFEHLAALEVTHQEKSEAGSIEYYNTEARDEFRCARVSARRLVIESRGLVLPVYANAHKLLYIVQGRGVFGMALPGCPETFQSVRSAFEMATGDAESSTRKLRDEHQKIHQFRQGDVIAVPPGVAHWLYNNGDSPVVAFSVIDFGNNANQLDPKPREFFLAGKPWGWCQQVQYSYQSEQQSKHQNIFAGFNPDLLAEALSVSRQTAMRLQELNDQRGAIIRVEQGLQLALDPSFQAEQEQEEQPQEYLSSQQQQPTWSQRSGACVQNNGLDEIMCAFKVSKNINSAQSTDIFNPRGGRITRANSQNFPVLNIIQMSATRTVLQNNALLTPHWTVNAHTVMYVTAGQGRIQVVDHRGRTVFDGELRQQQILLIPQNFAVAVKARHEGFSWVSFKTSHNAIDSQIAGKGSILRALPVDVLAKAYMLSREESRTLKYNRADETLVFAPRPEIQLYAESEK[SEQ ID 242]
豌豆蛋白质6(SEQ ID 8)的同源物
＞gi|164512534|emb|CAP06316.1|cvc[豌豆野生种(Pisum fulyum)]
MATTTKSRFPLLLLLGIIFLASVVCVTYANYDEGSEPRVPGRRERGRQEGEKEEKRHGEWRPSYEKEEDEEEGQRERGRQEGEKEEKRHGEWGPSYEKQEDEEEKQKYRYQREKEDEEEKQKYRYQREKKEQKEVQPGRERWEREEDEEHVDEEWRGSQRHEDPEERARLRYREERTKRDRRHQREGEEEERSSESQERRNPFLFKSNKFQTLFENENGHIRLLQRFDKRSDLFENLQNYRLVEYRAKPHTIFLPQHIDADLILVVLSGKAILTVLSPNARNSYNLERGDTIKLPAGTTSYLVNQDDEEDLRLVDLVIPVNGPGKFEAFDLSKNKNQYLRGFSKNILEASYNTKYETIEKVLLEEQEKTDAIVKVSREQIEELRKHAKSSSKKIFPSEFEPINLRNHKPEYSNKFGKLFEITPEKKYPQLQDLDIFVSCVEINEGALMLPHYNSRAIVVLLVNEGKGNLELLGLENEQQEREDRKERNNEVQRYEARLSPGDVVIIPAGHPVAITASSNLNLLAFGINAENNQRNFLSGSDDN[SEQ ID 243]
＞gi|164512526|emb|CAP06312.1| cvc[埃塞俄比亚豌豆]
MATTVESRFPLLLFPGIIFLASVCVTYANYDEGSETRVPGQRERGRQEGEKEEKRHGEWRPSYEKEEDEEEKQKYRYQREKEDEEEKQKYRYQREKKEEKEVQPGRERWEREEDEEQVDEEWRGSQRRQDPEERARLRHREERTKRDRRHKREGEEEERSSESQEQRNPFLFKSNKFLTLFENENGHIRLQRFDKRSDLFENLQNYRLVEYRAKPHTIFLPQHIDADLILVVLNGKAILTVLSPNDRNSYNLERGDTIKIPAGTTSYLVNQQDDEEDLRVVDFVIPVNRPGKFEAFGLSENKNQYLRGFSKNILEASLNTKYETIEKVLLEEQEKKPQQLRDRKRRQQGGERDAIIKVSREQIEELRKLAKSSSKKSLPSEFEPFNLRSHKPEYSNKFGKLFEITPEKKYPQLQDLDILVSCVEINKGALVLPHYNSRAIVVLLVNEGKGNLELLGLKNEQQEREDRKERNNEVQQRYEARLSPGDVVIIPAGHPVAISASSNLNLLGFGTNAENNQRNFLSGSDDN[SEQ ID 244]
＞gi|164512558|emb|CAP06328.1|cVc[长柔野豌豆]
MATTIKSRFPVLLLLGIIFLTSVCVTYANYDEGREPSVPGQRERGRQEGEKEEKRHGEWRPSEEDEEEKYKYEEGRVPGQRERGRQEGEKEEKRHGKWRPSEEEDEEEKYRYEEGSEPRGPGQRETGRQEGEKEKQRPEREPSYEKEEDEEEKQKYQYHREKKEQREVRPGRERFERHEDEEQWRGIQRHEDPEERARERYRAEIAKRQVEEEREERDIPHEREQRNPFLFKSNKFQTLFQNENGYIRRLQRFDKRSDLFENLQNYRLVEYRAKPHTIFLPQHIDADLIIVVLSGRAILTVLSPDDRNSYNLERGDTIKLPAGTTSYLVNQDDEEDLRVVDLAIPVNRPGKVESFLLSGNKNQYLRGFSKNILEASFNTNYETIERVLLEEQDKESQQSIGQKRRSQRQETNALVKVSREQLEDLKRLAKSSSQEGLSSQFEPINLRSQNPKYSNKFGKVFEITPEKKYPQLQDLDLFVSSVDIKEGALMLPHYNSRAIVVLLVNEGRGNLELVGLKNEQQEQREKEDEQQERNNQVQRYEARLSPGDVVIIPAGHPVAVRASSDLNLLAFGINAENNQRNFLAGSDDN[SEQ ID 245]
豌豆蛋白质7(SEQ ID 9)的同源物
＞gi|164512536|emb|CAP06317.1| cvc[硬毛山黧豆]
MAIIIKSRFPLLLLLGIIFLASVCATWANYDEGSEPRVPGQRERGRQEGEKAEKSHEKWRPSYEEEYDEGSEPRVPGKRERGRQEGEKEEKRHGEWRPSHEEEYDEGSEPRVPTHGERGRQEGEKEEKRHEEWRPSYEKEEDEEEKEKYKYQREKKEQKEVQPGREKWERKQDEKHVEEDEDQEEEQWRGSKRREDPEERARLRYREERTKSNVEEETEERRNPFLFKSNKFLTLFENENGHIRRLQRFDERSDIFENLQNYRLVEYKAKPHTMFLPQHIDADLIIVVLNGKAILTVLSPNDRNSYNLERGDTIKLPAGTTSYLVNQDDEEDLRVVDLAIPVNRPGKFEAFGLSANKNQYLRGFSKNILEAFLNTKYETIEKVLLEEQERRDRKGRQQGQETNAIVKVSREQIEELRKLAKSSSKKSLLSESEPINLRSQNPKYSNKFGKLFEITPEKKYPQLQDLDVSISCVEINEGAPLLPHYNSRAIVLLLVNEGKGNLELVGFKNEQQRQRENEERNKKVQRYEARLSPGDVVVIPAGHPVAISASLNLNLVGFGVNAENNQRNFLTGSDDN[SEQ ID 246]
＞gi|164512542|emb|CAP06320.1| cvc[扁荚山黧豆]
MATIIKSRFPLLLLLGIIFLASVCVTLANYDEGSEPRVPAQRERGRQEGEKEEKRHGEWRPSHEKEYDEGSEPRVPGRRERGRQEGEKEEKRHGEWRPSYEKEYDEGSEPRVPGRRERGRQEGEKEEKRHGEWRPSYEKEYDEEEKQKYQYEREKEEQKEVQPGRERWERKEDEEKEEDQWRGSQRHEDPEERARLRYRKERTKKYVEEDTEETSSESQGRRNPFLFKSNKFLTLFENENGYIRRLQRFDERSDIFENLQNYRLVEYRAKPHTIFLPQHIDADLILVILNGKAILTVLSPNDRNSYNLERGDTIKLPAGTTSYLVNEDDEEDLRVVDLVIPVNRPGKFEAFDLNQYLGGFSKSVLEASLNTKYETIEKVLLEEQQKQGQETNAIVKVSREQIEELRKLAKSSSKKSLLSELEPVNLRSHSPKYSNKFGKFFEITPEKKYPQLQDLDVSISCVEINEGALLLPHYNSRAIVVVLVNEGKGNLELLGVQNEDEQQERKERNKEVQRYEARLSPGDVVIIPSGHPVAVSASSNLNLLGFGINAENNQRNFLSGSDDN[SEQ ID 247]
＞gi|164512544IembICAP06321.1I共豌豆球蛋白[家山黧豆]
MATIIKSRFPLLLLLGIIFLASVCVTYANYDEGSEPRVPAQRERGRQEGEKEEKRHGEWRPSSEKEYDEGSEPRVPGRRERGRQEGEKEEKRHGEWRPSYEKEYDEEEKQKYQYEREKKEQKEVEPGRERWERKEDEEKEEDQWRGSQRHEDPEERARLRYRKERTKKYVEEDTEETSSESQGRRNPFLFKSNKFLTLFENENGYIRRLQRFDERSDLFENLQNYRLVEYRAKPHTIFLPQHIDADLILVILNGKAILTVLSPNDRNSYNLERGDTIKLPAGTTSYLVNEDDEEDLRVVDLVIPVNRPGKFEAFDLNQYLGGFSKSVLKASLNTKYETIEKVLLEEQQKQGQETNAIVKVSREQIEELRKLAKSSSKKSLLSELEPVNLRSHSPKYSNKFGKFFEITPEKKYPQLQDLDVSISCVEINEGALLLPHYNSRAIVVLLVNEGKGNLELLGVQDEDEQQERKKRNKEVQRYEARLSPSDVVIIPAGHPVAVSASSNLNLLGFGINAENNERNFLSGSDDN[SEQ ID248]
大米蛋白质3(SEQ ID 10)的同源物
＞gi|573918992|ref|XP_006647120.1|预测的：谷蛋白型-B2-样[短花药野生稻]
MATTVFSRFSTYFCVLLLCHGSMAQLFNPSTNPWHNPRQGSSRECRFDRLQPFEPLRKVRSEAGVTEYFDEKNELFQCTGTFVIRRVIQPQGLLVPRYTNAPGLVYIIQGRGSIGLTFPGCPATYQQQFQQFLPQEQSQSQKFRDEHQKIHQFRQGDIVALPAGVAHWFYNDGDAPVVAVYVYDVKNSANQLEPRQREFLLGGNNMRAQQVYGSSAEQHSRQNIFSGFGVEILSEALGISTVTTKRLQSQNDQRGEIIHVKNGLQFLKPTLTQQQEQAQAQYQEVQYSEQQQTSSRWNGLDENFCTIKARMNIENTSRADTYNPRAGRTTSLNSQKFPILNLVQMSATRVNLYQNAILSTFWNVNAHSLVYTIQGRARVQVVSNFGKTVFDGELRPGQLLIIPQHYVVLKKAQREGFRYIAIKTNANAFVSQLVGKNSVFRSLPVDVIANVYRISREQARSLKNNRGEEHGAFAPRSQQQSYPGFSNQSESETSE[SEQ ID 249]
＞gi|573919041|ref|XP_006647142.1|预测的：谷蛋白型-B4样[短花药野生稻]
MATTFSRFSIYFCVLLLCHGSMAQLFSPTLNPWHSSRRGGSRDCRFDRLQAFEPLRRVRSEAGVTEYFDERNEQFQCTGTFVIRRVIEPQGLLVPRYTNTPGVVYIMQGRGSMGLTFPGCPATYQQQFQQFLPEGQSQSQKFRDEHQKIHQFRQGDIVALPAGVAHWFYNEGDTPVVALYVFDINNSANQLEPRQKDFLLAGNNNREQQVYGRSIEKHSGQNIFSGFNHELLSEALGISTLAAKRLQGQNDHRGEIIRVRNGLQLLKPTFTQQQEQAQSQYQVQYSEKQQESTRCNGLDENFCTINARLNIENPSRADTYNPRAGRITHLNNQKFPILNLVQMSATRVNLYQNAILSPYWNVNAHSLVYMVQGHARVQVVSNLGKTVFNSVLRPGQLLIIPQHYVVLKKAEREGCQYIAFkTNANSIVSQLAGKNSILRAMPVDVVANAYRISREQARDLKNNRGEELGAFTPKFEQQSYPGLSNESESEASE[SEQ ID 2S0]
＞gi|10g894635|gb|ABG47337.1|谷蛋白前体[菰]
MNMATINGPTIFFTVCLFLLCHGSLAQLLGQSTSQWQSSHRGSSRQCRFDRLQAFEPVRSVRSQAGTTEFFDASNELFQCAGVSIVRRIIEPRGLLLPQYTNGATIMYIIQGRGITGQTFPGCPESYQQQFQQSMQAQLTGSQSQSQKFKDEHQKINRFRQGDVIALPAGVAHWCYNDGEVPVVAIYVIDINNAANQLDPRQRDFLLAGNMRSPQAYRREVENQSQNIFSGFSAELLSEALGISTGVARQLQCQNDQRGEIVRVEHGLSLLQPYASLQEQEQKQEQPRERYQVTQHQQSQYGGGCSNGLDETFCAMRIWQNIDNPNLADTYNPRAGRVTNLNSQKFPILNLIQMSAVKVNLYQNALLSPFWNINSHSVVYVTQGCARVQVVNNNGKTVFNGELRRGQLLIIPQHYVVVKKAQREGCAYIAFKTNPNSMVSHIVGKSSIFRALPTDVLANAYRISREDAQRLKHNRGDELGAFTPLQYKSYQDVSSVAASS[SEQ ID 251]
大米蛋白质4(SEQ ID 11)的同源物
＞gi|531874314|gb|AGT59174.1|谷蛋白，部分[籼稻组水稻]
CRFDRLQAFEPIRSVRSQAGTTEFFDVSNEQFQCTGVSAVRRVIEPRGLLLPHYTNGASLVYIIQGRGITGPTFPGCPESYQQQFQQSGQAQLTESQSQSHKFKDEHQKIHRFRQGDVIALPAGVAHWCYNDGEVPVVAIYVTDLNNGANQLDPRQRDFLLAGNKRNPQAYRREVEERSQNIFSGFSTELLSEALGVSSQVARQLQCQNDQRGEIVRVEHGLSLLQPYASLQEQEQGQVQSRERYQEGQYQQSQYGSGCSNGLDETFCTMKVRQNIDNPNRADTYNPRAGRVTNLNTQNFPILNLVQMSAVKVNLYQNALLSPFWNINAHSVVYITQGRARVQVVNNNGKTVFNGELRRGQLLIIPQHYAVVKKAQREGCAYIAFKTNPNSMVSHIAGKSSIFRALPNDVLANAYRISREEAQRLKHNRGDEFGAFTPIQYKSYQDVYNAAESS[SEQ ID 252]
＞gi|109894635|gb|ABG47337.1|谷蛋白前体[菰]
MNMATINGPTIFFTVCLFLLCHGSLAQLLGQSTSQWQSSHRGSSRQCRFDRLQAFEPVRSVRSQAGTTEFFDASNELFQCAGVSIVRRIIEPRGLLLPQYTNGATIMYIIQGRGITGQTFPGCPESYQQQFQQSMQAQLTGSQSQSQKFKDEHQKINRFRQGDVIALPAGVAHWCYNDGEVPVVAIYVIDINNAANQLDPRQRDFLLAGNMRSPQAYRREVENQSQNIFSGFSAELLSEALGISTGVARQLQCQNDQRGEIVRVEHGLSLLQPYASLQEQEQKQEQPRERYQVTQHQQSQYGGGCSNGLDETFCAMRIWQNIDNPNLADTYNPRAGRVTNLNSQKFPILNLIQMSAVKVNLYQNALLSPFWNINSHSVVYVTQGCARVQVVNNNGKTVFNGELRRGQLLIIPQHYVVVKKAQREGCAYIAFKTNPNSMVSHIVGKSSIFRALPTDVLANAYRISREDAQRLKHNRGDELGAFTPLQYKSYQDVSSVAASS[SEQ ID 253]
＞gi|472867|emb|CAA52764.1|11S球蛋白[燕麦]
MATTSFPSMLFYFCIFLLFHGSMAQLFGQSSTPWQSSRQGGLRGCRFDRLQAFEPLRQVRSQAGITEYFDEQNEQFRCTGVSVIRRVIEPQGLVLPQYHNAPALVYILQGRGFTGLTFPGCPATFQQQFQPFDQSQFAQGQRQSQTIKDEHQRVQRFKQGDVVALPAGIVHWCYNDGDAPIVAIYVFDVNNNANQLEPRQKEFLLAGNNKREQQSGNNIFSGLSVQLLSEALGISQQAAQRIQSQNDQRGEIIRVSQGLQFLKPIVSQQVPGEQQVYQPIQTQEGQATQYQVGQSTQYQVGKSTPYQGGQSSQYQAGQSWDQSFNGLEENFCSLEARKNIENPQHADTYNPRAGRITRLNSKNFPILNIVQMSATRVNLYQNAILSPFWNINAHSVIYMIQGHARVQVVNNNGQTVFNDILRRGQLLIVPQHFVVLKKAEREGCQYISFKTNPNSMVSHIAGKSSILRALPIDVLANAYRISRQEARNLKNNRGEEFGAFTPKLTQKGFQSYQDIEEGSSSPVRASE[SEQ ID 254]
大米蛋白质5(SEQ ID 12)的同源物
＞gi|225959|prf||1404367A谷蛋白
MASTNRPIVFFTVCLFLLCDGSLAQQLLGQSTSQWQSSRRGSPRGCRFDRLQAFEPIRSVRSQAGTTEFFDVSNELFQCTGVSVVRRVIEPRGLLLPHYTNGASLVYIIQGRGITGPTFPGCPETYQQQFQQSGQAGLTESQSQSHKFKDEHQKIHRFRQGDVIALPAGVAHWCYNDCEVPVVAIYVTDINNGANQLDPRQRDFLLAGNKRNPQAYRREVEFWSQNIFSGFSTELLSEAFGISNQVARQLQCQNDQKGEIVRVERGLSLLQPYASLQEQEQGQMQSREHYQEGGYQQSQYGSGCPNGLDETFCVNKVRQNIDNPNRADTYNPRAGRVTNLSQNFPILNLVQMSAVKVNLYQNTDTWISMGQEENALLSPFWNINAHSIVYITQGRAQVQVLRRGQLLIVPQHYVVVKKAQREGCAYIAFKTNPNSMVSHIAGKSSIFRALPTDVLANAYRISREEAQRLKHNRGDEFGAFTPLQYKSYQDVYNVAESS[SEQ ID 255]
＞gi|573943558|ref|XP_006654150.1|预测的：谷蛋白型-A3样[短花药野生稻]
MKSSIVFSTICLVLLCHGSLAQLLSQSTSQWQSSRRGSPRQCRFDQLQAFEPIRTVRSQAGVTEFYDVSNELFQCTGVSVVRRVIEPRGLLLPHYSNGATLVYIIQGRGITGPTFPGCPETYQQQFQQSGEAQPFEGQSHKFRDEHQKIHRFRQGDVVALPAGVAHWCYNDGEVPIVAIYVTDIYNSANQLDPRHRDFFLAGNNKVAQQLYRSEARENSKNIFGGFSVELLSEALGISRGVARQLQCQNDQRGEIVRVEHGLALLQPYASVQEQQQEQVQSRDYEQTQYQQKQPQGSCSNGLDETFCTMRLRQNIDNPNLADTYNPKAGRITYLNGQKFPILNLVQMSAVKVNLYQNAVLSPFWNINAHS
VVYITQGRARVQVVNNNGKTVFDGELRQGQLLIIPQHHVVLKKAQREGCSYIALKTNPNSIVSHIAGKNSIFRALPGDVVTNAYRISREEAKRIKHNRGDESGVFAPSHAYRSYQDMSVAA[SEQ ID 256]
＞gi|721641733|ref|XP-010231907.1|预测的：12S种子贮藏球蛋白1样[二穗短柄草]
MAHTSFSSFLSYFCLFLLFHGSMAQVLGQVSTWQSSRQGGSRDCSFDRLQAIEPVTQVRSQAGLTEYFDEQNEQFRCAGVFVIRRVIEPRGLLLPRYHNTPGLVYILQGNGFVGLTFPGCPETFREQFQQFRQTQSTLGQSQCQSQKLGDVHQRVHQFTQGDVVALPTGVAHWIYNGGDAPVVIVYVFDVNNNANQLEPRQKEFLLGGNYNGVLQYGQNIFSGFNAQLLSQAFGINEQTSQRIQNQNDGRGDIIRVDNGLQFLKPVVTQQQPEQPFMPIQHQTGQSSRNGLEENFCSLEPRQNIEDPNRADTYNPRAGSITRLNGQNFPILNLVQMSATRVNLQKNAILSPFWNINAHSVVYVIQGHALVQVVNNQGHNVFNGLLHRGQLLIIPQNYVVLKKAESEGYQYIAFKTNANSMVSHIAGKNSILRALPVDVIANAYRISRQEAQNLKNNRGEETGVLTPNFSQSTCQSYQTEDVQSLRPMSHWSE[SEQ ID 257]
大米蛋白质6(SEQ ID 13)的同源物
＞gi|169244463|gb|ACA50S05.1|种子过敏性蛋白RAG2[粳稻组水稻]
MASNKVVFSALLLIIVSVLAATATMADHHKDQVVYSLGERCQPGMGYPMYSLPRCRAVVKRQCVGHGAPGGAVDEQLRQDCCRQLAAVDDSWCRCSALNHMVGGIYRELGATDVGHPMAXVFPGCRRGDLERAAASLPAFCNVDIPNGTGGVCYWLGYPRTPRTGH[SEQ ID 258]
＞gi|5777592|emb|CAA44001.1|低分子量球蛋白[水稻(Oryzasativa)]
MASNKVVFSALLLIIVSVLRRDGTMADHHKDQVVYSLGERCQPGMGYPMYSLPRCRAVVKRQCVGHGAPGAVDEQLRQDCCRQLAAVDDSWCRCSALNHMVGGIYRELGATDVGHPMAEVFPGCRRGDLERAAASLPAFCNVDIPNGTGGVCYWLGYPRTPRTGH[SEQ ID 259]
＞gi|115471175|ref|NP_001059186.1|Os07g0214600[粳稻组水稻]＞gi|23616954|dbj|BAC20657.1|过敏原RA16[粳稻组水稻]＞gi|113610722|dbj|BAF21100.1|Os07g0214600[粳稻组水稻
]＞gi|125557687|gb|EAZ03223.1|假定蛋白质Osl_25372|籼稻组水稻]
MASNKVVISALLVVVVSVLAATTTMADHHQEQVVYTPGQLCQPGIGYPTYPLPRCRAFVKRQCVAPGTVDEQVRRGCCRQLAAIDSSWCRCDALNHMLRIIYRESGAADAGHPMAEVFRGCRRGDIERAAASLPAFCNVDIPNGVGGVCYWLPGTGY[SEQ ID 260]
大米蛋白质7(SEQ ID 14)的同源物
＞gi|115445309|ref|NP_001046434.1|Os02g0248800[粳稻组水稻]＞gi|37993738|gb|AAR06952.1|谷蛋白B型[粳稻组水稻]＞gi|47497729|dbj|BAD19794.1|谷蛋白B型[粳稻组水稻
]＞gi|113535965|dbj|BAF08348.1|Os02g0248800[粳稻组水稻]＞gi|215768942|dbj|BAH01171.1|未命名蛋白质产物[粳稻组水稻]＞gi|284431772|gb|ADB84627.1|谷蛋白[粳稻组水稻]
MTISVFSRFSIYFCVLLLCNGSMAQLFDPATNQWQTHRQGSFRECRFERLQAFEPLQNVRSEAGVTEYFDETNELFQCTGTFVIRRVIQPQGLLIPRYANTPGMVYIIQGRGSMGLTFPGCPATYQQQSQQFLFQGESQSQKFIDEHQKIHQFRQGDIVVLPTGVAHWFYNDGDTPVVALYVYDINNSANQLEPRHREFLLAGKNNRVQQVYGRSIQQHSGQNIFNGFSVEPLSEALNINTVTTKRLQSQNDQRGEIIHVKNGLQLLKPTLTQRQEQEQAQYQEVQYSEKPQTSSRWNGLEENLCTIKTRLNIENPSRADSYDPRAGRITSLDSQKFPILNIIQMSATRVNLYQNAILTPFWNVNAHSLMYVIRGRARVQVVSNFGKTVFDGVLRPEQLLIIPQNYVVLKKAQHEGCQYIAINTNANAFVSHLAGVDSVFHALPVDVIANAYCISREEARRLKNNRGDEYGPFPPRLQQQIYPEFSNESKGETSE[SEQ ID 261]
＞gi|428674402|gb|AFZ41188.1|谷蛋白，部分[粳稻组水稻]
LLCHGSMAQIFSLGINPWQNPRQGGSRECRFDRLQAFEPLRKVRHEAGVTEYFDEKNEQFQCTGTLVIRRIIEPQGLLLPRYSNTPGLVYIIQGTGVLGLTFPGCPATYQKQFRHFGLEGGSQRQGKKLRDENQKIHQFRQGDVVALPSGIPHWFYNEGDTPVVALFVFDVNNNANQLEPRQKEFLLAGNNIEQQVSNPSINKHSGQNIFNGFNTKLLSEALGVNIEVTRRLQSQNDRRGDIIRVKNGLRLIKPTITQQQEQTQDQYQQIQYHREQRSTSKYNGLDENFCAIRARLNIENPNHADTYNPRAGRITNLNSQKFSILNLVQMSATRVNLYQNAILSPFWNINAHSLVYTIQGRARVQVVSNHGKAVFNGVLRPGQLLIIPQNYVVMKKAELEGFQFIAFKTNPNAMVNHIAGKNSVLRAMPVDVIANAYRISRQEARSLKNNRGEEIGAFTPRYQQQKIHQEYSNPNESETQ[SEQ ID 2G2]
＞gi|226510|prf||1515394A种子贮藏球蛋白
MATRFPSLLFYSCIFLLCNGSMAQLFGQSFTPWQSSRQGGLRGCRFDRLQAFEPLRQVRSQAGITEYFDEQNEQFRCAGVSVIRRVIEPQGLLLPQYHNAPGLVYILQGRGFTGLTFPGCPATFQQQFQPFDQARFAQGQSKSQNLKDEHQRVHHIKQGDVVALPAGIVHWCYNDGDAPIVAVYVFDVNNNANQLEPRQKEFLLAGNNKREQQFGQNIFSGFSVQLLSEALGISQQAAQKIQSQNDQRGEIIRVSQGLQFLKPFVSQQGPVEHQAYQPIQSQQEQSTQYQVGQSPQYQEGQSTQYQSGQSWDQSFNGLEENFCSLEARQNIENPKRADTYNPRAGRITHLNSKNFPTLNLVQMSATRVNLYQNAILSPYWNINAHSVMHMIQGRARVQVVNNHGQTVFNDILRRGQLLIIPQHYVVLKKAEREGCQYISFKTTPNSMVSYIAGKTSILRALPVDVLANAYRISRQESQNLKNNRGEEFGAFTPKFAQTGSQSYQDEGESSSTEKASE[SEQ ID263]
大米蛋白质8(SEQ ID 15)的同源物
＞gi|83375868|gb|ABC17777.1|蜡状[普通野生稻]
MSALTTSQLATSATGFGIADRSAPSSLLRHGFQGLKPRSPAGGDATSLSVTTSARATPKQQRSVQRGSRRFPSVVVYATGAGMNVVFVGAEMAPWSKTGGLGDVLGGLPPAMAANGHRVMVISPRYDQYKDAWDTSVVAEIKVADRYERVRFFHCYKRGVDRVFVDHPSFLEKVWGKTGEKIYGPDTGVDYKDNQMRFSLLCQAPRILNLNNNPYFKGTYGEDVVFVCNDWHTGPLASYLKNNYQPNGIYRNAKVAFCIHNISYQGRFAFEDYPELNLSERFRSSFDFIDGYDTPVEGRKINWMKAGILEADRVLTVSPYYAEELISGIARGCELDNIMRLTGITGIVNGMDVSEWDPSKDKYITAKYDATTAIEAKALNKEALQAEAGLPVDRKIPLIAFIGRLEEQKGPDVMAAAIPELMQEDVQIVLLGTGKKKFEKLLKSMEEKYPGKVRAVVKFNAPLAHLIMAGADVLAVPSRFEPCGLIQLQGMRYGTPCACASTGGLVDTVIEGKTGFHMGRLSVDCKVVEPSDVKKVAATLKRAIKVVGTPAYEEMVRNCMNQDLSWKGPAKNWENVLLGLGVAGSAPGIEGDEIAPLAKENVAAP[SEQ ID 264]
＞gi|297614332|gb|ADI48504.1|糖原合成酶[药用野生稻]
MSALTTSQLATSATGFGIADRSAPSSLLRHGFQGLKPRSPAGGDASSLSVTTSARATPKQQRSVQRGSRRFPSVVVYATGAGMNVVFVGAEM APWSKTGGLGDVLGGLPPAMAANGHRVMVISPRHDQYKDAWDTSVVAEIKVADRYERVRFFHCYKRGVDRVFIDHPSFLEKVWGKTGEKI YGPDTGVDYKDNQMRFSLLCQAALEAPRILNLNNNPYFKGTYGEDVVFVCNDWHTGPLPSYLKNNYQPNGIYRNAKVAFCIHNISYQGRFAF EDYPELNLSERFRSSFDFIDGYDTPVEGRKINWMKAGILESDRVLTVSPYYAEELISGIARGCELDNIMRLTGITGIVNGMDVSEWDPSKDKYIAAKYDATTAIEAKALNKEALQAEAGLPVDRKIPLIAFIGRLEEQKGPDVMAAAIPELMQENVQIVLLGTGKKKFEKLLKSMEEKYPGKVRAVVKF NAPLAHLIMAGADVLAVPSRFEPCGLIQLQGMRYGTPCACASTGGLVDTVIEGKTGFHMGRLSVDCKVVEPSDVQKVATTLKRAIKIVGTPAY NEMVRNCMNQDLSWKGPAKNWENVLLGLGVAGSAPGVEGEEIAPLAKENVAAP[SEQ ID 265]
＞gi|389620054|gb|AFK93486.1|颗粒结合淀粉合成酶[青稞]
MAALATSQLATSGTVLGVTDRFRRPGFQG LRPRNPADAALGMRTIGASAAPKQSRKAHRGSRRCLSVVVRATGSGMNLVFVGAEMAPWS KTGGLGDVLGGLPPAMAANGHRVMVVSPRYDQYKDAWDTSVI5EIKVADEYERVRFFHCYKRGVDRVFIDHPWFLEKVRGKTKEKIYGPDA GTDYEDNQQRFSLLCQAALEAPRILNLNNNPYFSGPYGEDVVFVCNDWHTGLLACYLKSNYQSNGIYRTAKVAFCIHNISYQGRFSFDDFAQL NLPDRFKSSFDFIDGYDKPVEGRKINWMKAGILQADKVLTVSPYYAEELISDEARGCELDNIMRLTGITGIVNGMDVSEWDPTKDKFLAVNYDITTALEAKALNKEALQAEVGLPVDRKVPLVAFIGRLEEQKGPDVMIAAIPEILKEEDVQIILLGTGKKKFEKLLKSMEEKFPGKVRAVVRFNAPLAH QMMAGADLLAVTSRFEPCGLIQLQGMRYGTPCVCASTGGLVDTIVEGKTGFHMGRLSVDCNVVEPADVKKVATTLKRAVKVVGTPAYQEM VKNCMIQDLSWKGPAKNWEDVLLELGVEGSEPGIVGEEIAPLAMENVAAP[SEQ ID 266]
GLUC(金黄色葡萄球菌)蛋白质1(SEQ ID 16)的同源物
＞gi|446599182|ref|WP_000676528.1|谷氨酰内肽酶[金黄色葡萄球菌]＞gi|253729369|gb|EES98098.1|胰蛋白酶[金黄色葡萄球菌金黄色亚种TCH130]＞gi|341844549|gb|EGS85761.1|谷氨酰内肽酶
[金黄色葡萄球菌金黄色亚种21259]＞gi|537390486lgb|AGU61109.1|谷氨酰内肽酶前体
[金黄色葡萄球菌金黄色亚种CN1]＞gi|564714561|gb|ETD14665.1|谷氨酰内肽酶[金黄色葡萄球菌
金黄色亚种KPL1845]＞gi|577466329|gb|EUG79766.1|谷氨酰内肽酶[金黄色葡萄球菌M0139]
＞gi|580560623|gb|EVF84961.1|谷氨酰内肽酶[金黄色葡萄球菌COAS6020]
＞gi|580687002|gb|EVH10169.1|谷氨酰内肽酶[金黄色葡萄球菌UCIM6080]
＞gi|751815683|gb|KIN24957.1|谷氨酰内肽酶[金黄色葡萄球菌MRSA_CVM43477]
＞gi|781884797|dbj|BAR08486.1|谷氨酰内肽酶前体[金黄色葡萄球菌金黄色亚种]
＞gi|781887762|dbj|BAR11210.1|谷氨酰内肽酶前体[金黄色葡萄球菌金黄色亚种]
MKGKFLKVSSLFVATLTTATLVSSPAANALSSKAMDNHPQQSQSSKQQTPKIQKGGNLKPLEQREHANVILPNNDRHQITDTTNGHYAPVTYIQVEAPTGTFIASGVVVGKDTLLTNKHVVDATHGDPHALKAFPSAINQDNYPNGGFTAEQITKYSGEGDLAIVKFSPNEQNKHIGEVVKPATMSNNAETQVNQNITVTGYPGDKPVATMWESKGKITYLKGEAMQYDLSTTGGNSGSPVFNEKNEVIGIHWGGVPNEFNGAVFINENVRNFLKQNIEDIHFANDDQPNNPDNPDNPNNPDNPNNPDEPNNPDNPNNPDNPDNGDNNNSDNPDAA[SEQ ID 267]
序列表
<110> 努里塔斯有限公司
<120> 抗炎肽及其用途
<130> P11683EPDIV1
<140> EP20165063.7
<141> 2016-07-18
<150> 15177013.8
<151> 2015-07-16
<160> 425
<170> PatentIn version 3.5
<210> 1
<211> 459
<212> PRT
<213> 豌豆
<400> 1
Met Ala Ala Thr Thr Met Lys Ala Ser Phe Pro Leu Leu Met Leu Met
1 5 10 15
Gly Ile Ser Phe Leu Ala Ser Val Cys Val Ser Ser Arg Ser Asp Pro
20 25 30
Gln Asn Pro Phe Ile Phe Lys Ser Asn Lys Phe Gln Thr Leu Phe Glu
35 40 45
Asn Glu Asn Gly His Ile Arg Leu Leu Gln Lys Phe Asp Gln Arg Ser
50 55 60
Lys Ile Phe Glu Asn Leu Gln Asn Tyr Arg Leu Leu Glu Tyr Lys Ser
65 70 75 80
Lys Pro His Thr Ile Phe Leu Pro Gln His Thr Asp Ala Asp Tyr Ile
85 90 95
Leu Val Val Leu Ser Gly Lys Ala Ile Leu Thr Val Leu Lys Pro Asp
100 105 110
Asp Arg Asn Ser Phe Asn Leu Glu Arg Gly Asp Thr Ile Lys Leu Pro
115 120 125
Ala Gly Thr Ile Ala Tyr Leu Val Asn Arg Asp Asp Asn Glu Glu Leu
130 135 140
Arg Val Leu Asp Leu Ala Ile Pro Val Asn Arg Pro Gly Gln Leu Gln
145 150 155 160
Ser Phe Leu Leu Ser Gly Asn Gln Asn Gln Gln Asn Tyr Leu Ser Gly
165 170 175
Phe Ser Lys Asn Ile Leu Glu Ala Ser Phe Asn Thr Asp Tyr Glu Glu
180 185 190
Ile Glu Lys Val Leu Leu Glu Glu His Glu Lys Glu Thr Gln His Arg
195 200 205
Arg Ser Leu Lys Asp Lys Arg Gln Gln Ser Gln Glu Glu Asn Val Ile
210 215 220
Val Lys Leu Ser Arg Gly Gln Ile Glu Glu Leu Ser Lys Asn Ala Lys
225 230 235 240
Ser Thr Ser Lys Lys Ser Val Ser Ser Glu Ser Glu Pro Phe Asn Leu
245 250 255
Arg Ser Arg Gly Pro Ile Tyr Ser Asn Glu Phe Gly Lys Phe Phe Glu
260 265 270
Ile Thr Pro Glu Lys Asn Pro Gln Leu Gln Asp Leu Asp Ile Phe Val
275 280 285
Asn Ser Val Glu Ile Lys Glu Gly Ser Leu Leu Leu Pro His Tyr Asn
290 295 300
Ser Arg Ala Ile Val Ile Val Thr Val Asn Glu Gly Lys Gly Asp Phe
305 310 315 320
Glu Leu Val Gly Gln Arg Asn Glu Asn Gln Gln Glu Gln Arg Lys Glu
325 330 335
Asp Asp Glu Glu Glu Glu Gln Gly Glu Glu Glu Ile Asn Lys Gln Val
340 345 350
Gln Asn Tyr Lys Ala Lys Leu Ser Ser Gly Asp Val Phe Val Ile Pro
355 360 365
Ala Gly His Pro Val Ala Val Lys Ala Ser Ser Asn Leu Asp Leu Leu
370 375 380
Gly Phe Gly Ile Asn Ala Glu Asn Asn Gln Arg Asn Phe Leu Ala Gly
385 390 395 400
Asp Glu Asp Asn Val Ile Ser Gln Ile Gln Arg Pro Val Lys Glu Leu
405 410 415
Ala Phe Pro Gly Ser Ala Gln Glu Val Asp Arg Ile Leu Glu Asn Gln
420 425 430
Lys Gln Ser His Phe Ala Asp Ala Gln Pro Gln Gln Arg Glu Arg Gly
435 440 445
Ser Arg Glu Thr Arg Asp Arg Leu Ser Ser Val
450 455
<210> 2
<211> 124
<212> PRT
<213> 豌豆
<400> 2
Asp Arg Arg Gln Glu Leu Ser Asn Glu Asn Val Leu Val Lys Val Ser
1 5 10 15
Arg Arg Gln Leu Glu Glu Leu Ser Lys Asn Ala Lys Ser Ser Ser Arg
20 25 30
Arg Ser Val Ser Ser Glu Ser Gly Pro Phe Asn Leu Arg Ser Glu Asp
35 40 45
Pro Leu Tyr Ser Asn Asn Ser Gly Lys Phe Phe Glu Leu Thr Pro Glu
50 55 60
Lys Asn Gln Gln Leu Gln Asp Leu Asp Leu Phe Val Asn Ser Val Asp
65 70 75 80
Leu Lys Glu Gly Ser Leu Leu Leu Pro Asn Tyr Asn Ser Arg Ala Leu
85 90 95
Leu Val Leu Val Leu Val Val Asn Glu Gly Lys Gly Asp Phe Glu Leu
100 105 110
Val Gly Gln Arg Asn Glu Asn Gln Gly Lys Glu Asn
115 120
<210> 3
<211> 520
<212> PRT
<213> 豌豆
<400> 3
Met Ala Thr Lys Leu Leu Ala Leu Ser Leu Ser Phe Cys Phe Leu Leu
1 5 10 15
Leu Gly Gly Cys Phe Ala Leu Arg Glu Gln Pro Glu Gln Asn Glu Cys
20 25 30
Gln Leu Glu Arg Leu Asn Ala Leu Glu Pro Asp Asn Arg Ile Glu Ser
35 40 45
Glu Gly Gly Leu Ile Glu Thr Trp Asn Pro Asn Asn Lys Gln Phe Arg
50 55 60
Cys Ala Gly Val Ala Leu Ser Arg Ala Thr Leu Gln His Asn Ala Leu
65 70 75 80
Arg Arg Pro Tyr Tyr Ser Asn Ala Pro Gln Glu Ile Phe Ile Gln Gln
85 90 95
Gly Asn Gly Tyr Phe Gly Met Val Phe Pro Gly Cys Pro Glu Thr Phe
100 105 110
Glu Glu Pro Gln Glu Ser Glu Gln Gly Glu Gly Arg Arg Tyr Arg Asp
115 120 125
Arg His Gln Lys Val Asn Arg Phe Arg Glu Gly Asp Ile Ile Ala Val
130 135 140
Pro Thr Gly Ile Val Phe Trp Met Tyr Asn Asp Gln Asp Thr Pro Val
145 150 155 160
Ile Ala Val Ser Leu Thr Asp Ile Arg Ser Ser Asn Asn Gln Leu Asp
165 170 175
Gln Met Pro Arg Arg Phe Tyr Leu Ala Gly Asn His Glu Gln Glu Phe
180 185 190
Leu Arg Tyr Gln His Gln Gln Gly Gly Lys Gln Glu Gln Glu Asn Glu
195 200 205
Gly Asn Asn Ile Phe Ser Gly Phe Lys Arg Asp Phe Leu Glu Asp Ala
210 215 220
Phe Asn Val Asn Arg His Ile Val Asp Arg Leu Gln Gly Arg Asn Glu
225 230 235 240
Asp Glu Glu Lys Gly Ala Ile Val Lys Val Lys Gly Gly Leu Ser Ile
245 250 255
Ile Ser Pro Pro Glu Lys Gln Ala Arg His Gln Arg Gly Ser Arg Gln
260 265 270
Glu Glu Asp Glu Asp Glu Asp Glu Glu Arg Gln Pro Arg His Gln Arg
275 280 285
Gly Ser Arg Gln Glu Glu Glu Glu Asp Glu Asp Glu Glu Arg Gln Pro
290 295 300
Arg His Gln Arg Arg Arg Gly Glu Glu Glu Glu Glu Asp Lys Lys Glu
305 310 315 320
Arg Arg Gly Ser Gln Lys Gly Lys Ser Arg Arg Gln Gly Asp Asn Gly
325 330 335
Leu Glu Glu Thr Val Cys Thr Ala Lys Leu Arg Leu Asn Ile Gly Pro
340 345 350
Ser Ser Ser Pro Asp Ile Tyr Asn Pro Glu Ala Gly Arg Ile Lys Thr
355 360 365
Val Thr Ser Leu Asp Leu Pro Val Leu Arg Trp Leu Lys Leu Ser Ala
370 375 380
Glu His Gly Ser Leu His Lys Asn Ala Met Phe Val Pro His Tyr Asn
385 390 395 400
Leu Asn Ala Asn Ser Ile Ile Tyr Ala Leu Lys Gly Arg Ala Arg Leu
405 410 415
Gln Val Val Asn Cys Asn Gly Asn Thr Val Phe Asp Gly Glu Leu Glu
420 425 430
Ala Gly Arg Ala Leu Thr Val Pro Gln Asn Tyr Ala Val Ala Ala Lys
435 440 445
Ser Leu Ser Asp Arg Phe Ser Tyr Val Ala Phe Lys Thr Asn Asp Arg
450 455 460
Ala Gly Ile Ala Arg Leu Ala Gly Thr Ser Ser Val Ile Asn Asn Leu
465 470 475 480
Pro Leu Asp Val Val Ala Ala Thr Phe Asn Leu Gln Arg Asn Glu Ala
485 490 495
Arg Gln Leu Lys Ser Asn Asn Pro Phe Lys Phe Leu Val Pro Ala Arg
500 505 510
Gln Ser Glu Asn Arg Ala Ser Ala
515 520
<210> 4
<211> 613
<212> PRT
<213> 豌豆
<400> 4
Met Ala Thr Thr Ile Lys Ser Arg Phe Pro Leu Leu Leu Leu Leu Gly
1 5 10 15
Ile Ile Phe Leu Ala Ser Val Val Cys Val Thr Tyr Ala Asn Tyr Asp
20 25 30
Glu Gly Ser Glu Pro Arg Val Pro Ala Gln Arg Glu Arg Gly Arg Gln
35 40 45
Glu Gly Glu Lys Glu Glu Lys Arg His Gly Glu Trp Arg Pro Ser Tyr
50 55 60
Glu Lys Glu Glu Asp Glu Glu Glu Gly Gln Arg Glu Arg Gly Arg Gln
65 70 75 80
Glu Gly Glu Lys Glu Glu Lys Arg His Gly Glu Trp Arg Pro Ser Tyr
85 90 95
Glu Lys Gln Glu Asp Glu Glu Glu Lys Gln Lys Tyr Arg Tyr Gln Arg
100 105 110
Glu Lys Glu Asp Glu Glu Glu Lys Gln Lys Tyr Gln Tyr Gln Arg Glu
115 120 125
Lys Lys Glu Gln Lys Glu Val Gln Pro Gly Arg Glu Arg Trp Glu Arg
130 135 140
Glu Glu Asp Glu Glu Gln Val Asp Glu Glu Trp Arg Gly Ser Gln Arg
145 150 155 160
Arg Glu Asp Pro Glu Glu Arg Ala Arg Leu Arg His Arg Glu Glu Arg
165 170 175
Thr Lys Arg Asp Arg Arg His Gln Arg Glu Gly Glu Glu Glu Glu Arg
180 185 190
Ser Ser Glu Ser Gln Glu Arg Arg Asn Pro Phe Leu Phe Lys Ser Asn
195 200 205
Lys Phe Leu Thr Leu Phe Glu Asn Glu Asn Gly His Ile Arg Leu Leu
210 215 220
Gln Arg Phe Asp Lys Arg Ser Asp Leu Phe Glu Asn Leu Gln Asn Tyr
225 230 235 240
Arg Leu Val Glu Tyr Arg Ala Lys Pro His Thr Ile Phe Leu Pro Gln
245 250 255
His Ile Asp Ala Asp Leu Ile Leu Val Val Leu Ser Gly Lys Ala Ile
260 265 270
Leu Thr Val Leu Ser Pro Asn Asp Arg Asn Ser Tyr Asn Leu Glu Arg
275 280 285
Gly Asp Thr Ile Lys Leu Pro Ala Gly Thr Thr Ser Tyr Leu Val Asn
290 295 300
Gln Asp Asp Glu Glu Asp Leu Arg Leu Val Asp Leu Val Ile Pro Val
305 310 315 320
Asn Gly Pro Gly Lys Phe Glu Ala Phe Asp Leu Ala Lys Asn Lys Asn
325 330 335
Gln Tyr Leu Arg Gly Phe Ser Lys Asn Ile Leu Glu Ala Ser Tyr Asn
340 345 350
Thr Arg Tyr Glu Thr Ile Glu Lys Val Leu Leu Glu Glu Gln Glu Lys
355 360 365
Asp Arg Lys Arg Arg Gln Gln Gly Glu Glu Thr Asp Ala Ile Val Lys
370 375 380
Val Ser Arg Glu Gln Ile Glu Glu Leu Lys Lys Leu Ala Lys Ser Ser
385 390 395 400
Ser Lys Lys Ser Leu Pro Ser Glu Phe Glu Pro Ile Asn Leu Arg Ser
405 410 415
His Lys Pro Glu Tyr Ser Asn Lys Phe Gly Lys Leu Phe Glu Ile Thr
420 425 430
Pro Glu Lys Lys Tyr Pro Gln Leu Gln Asp Leu Asp Leu Phe Val Ser
435 440 445
Cys Val Glu Ile Asn Glu Gly Ala Leu Met Leu Pro His Tyr Asn Ser
450 455 460
Arg Ala Ile Val Val Leu Leu Val Asn Glu Gly Lys Gly Asn Leu Glu
465 470 475 480
Leu Leu Gly Leu Lys Asn Glu Gln Gln Glu Arg Glu Asp Arg Lys Glu
485 490 495
Arg Asn Asn Glu Val Gln Arg Tyr Glu Ala Arg Leu Ser Pro Gly Asp
500 505 510
Val Val Ile Ile Pro Ala Gly His Pro Val Ala Ile Thr Ala Ser Ser
515 520 525
Asn Leu Asn Leu Leu Gly Phe Gly Ile Asn Ala Glu Asn Asn Glu Arg
530 535 540
Asn Phe Leu Ser Gly Ser Asp Asp Asn Val Ile Ser Gln Ile Glu Asn
545 550 555 560
Pro Val Lys Glu Leu Thr Phe Pro Gly Ser Val Gln Glu Ile Asn Arg
565 570 575
Leu Ile Lys Asn Gln Lys Gln Ser His Phe Ala Asn Ala Glu Pro Glu
580 585 590
Gln Lys Glu Gln Gly Ser Gln Gly Lys Arg Ser Pro Leu Ser Ser Ile
595 600 605
Leu Gly Thr Phe Tyr
610
<210> 5
<211> 438
<212> PRT
<213> 豌豆
<400> 5
Met Ala Ala Thr Pro Ile Lys Pro Leu Met Leu Leu Ala Ile Ala Phe
1 5 10 15
Leu Ala Ser Val Cys Val Ser Ser Arg Ser Asp Gln Glu Asn Pro Phe
20 25 30
Ile Phe Lys Ser Asn Arg Phe Gln Thr Leu Tyr Glu Asn Glu Asn Gly
35 40 45
His Ile Arg Leu Leu Gln Lys Phe Asp Lys Arg Ser Lys Ile Phe Glu
50 55 60
Asn Leu Gln Asn Tyr Arg Leu Leu Glu Tyr Lys Ser Lys Pro Arg Thr
65 70 75 80
Leu Phe Leu Pro Gln Tyr Thr Asp Ala Asp Phe Ile Leu Val Val Leu
85 90 95
Ser Gly Lys Ala Thr Leu Thr Val Leu Lys Ser Asn Asp Arg Asn Ser
100 105 110
Phe Asn Leu Glu Arg Gly Asp Thr Ile Lys Leu Pro Ala Gly Thr Ile
115 120 125
Ala Tyr Leu Ala Asn Arg Asp Asp Asn Glu Asp Leu Arg Val Leu Asp
130 135 140
Leu Thr Ile Pro Val Asn Lys Pro Gly Gln Leu Gln Ser Phe Leu Leu
145 150 155 160
Ser Gly Thr Gln Asn Gln Pro Ser Leu Leu Ser Gly Phe Ser Lys Asn
165 170 175
Ile Leu Glu Ala Ala Phe Asn Thr Asn Tyr Glu Glu Ile Glu Lys Val
180 185 190
Leu Leu Glu Gln Gln Glu Gln Glu Pro Gln His Arg Arg Ser Leu Lys
195 200 205
Asp Arg Arg Gln Glu Ile Asn Glu Glu Asn Val Ile Val Lys Val Ser
210 215 220
Arg Glu Gln Ile Glu Glu Leu Ser Lys Asn Ala Lys Ser Ser Ser Lys
225 230 235 240
Lys Ser Val Ser Ser Glu Ser Gly Pro Phe Asn Leu Arg Ser Arg Asn
245 250 255
Pro Ile Tyr Ser Asn Lys Phe Gly Lys Phe Phe Glu Ile Thr Pro Glu
260 265 270
Lys Asn Gln Gln Leu Gln Asp Leu Asp Ile Phe Val Asn Ser Val Asp
275 280 285
Ile Lys Glu Gly Ser Leu Leu Leu Pro Asn Tyr Asn Ser Arg Ala Ile
290 295 300
Val Ile Val Thr Val Thr Glu Gly Lys Gly Asp Phe Glu Leu Val Gly
305 310 315 320
Gln Arg Asn Glu Asn Gln Gly Lys Glu Asn Asp Lys Glu Glu Glu Gln
325 330 335
Glu Glu Glu Thr Ser Lys Gln Val Gln Leu Tyr Arg Ala Lys Leu Ser
340 345 350
Pro Gly Asp Val Phe Val Ile Pro Ala Gly His Pro Val Ala Ile Asn
355 360 365
Ala Ser Ser Asp Leu Asn Leu Ile Gly Phe Gly Ile Asn Ala Glu Asn
370 375 380
Asn Glu Arg Asn Phe Leu Ala Gly Glu Glu Asp Asn Val Ile Ser Gln
385 390 395 400
Val Glu Arg Pro Val Lys Glu Leu Ala Phe Pro Gly Ser Ser His Glu
405 410 415
Val Asp Arg Leu Leu Lys Asn Gln Lys Gln Ser Tyr Phe Ala Asn Ala
420 425 430
Gln Pro Leu Gln Arg Glu
435
<210> 6
<211> 484
<212> PRT
<213> 水稻
<400> 6
Met Ala Thr Thr Thr Ser Leu Leu Ser Ser Cys Leu Cys Ala Leu Leu
1 5 10 15
Leu Ala Pro Leu Phe Ser Gln Gly Val Asp Ala Trp Glu Ser Arg Gln
20 25 30
Gly Ala Ser Arg Gln Cys Arg Phe Asp Arg Leu Gln Ala Phe Glu Pro
35 40 45
Leu Arg Lys Val Arg Ser Glu Ala Gly Asp Thr Glu Tyr Phe Asp Glu
50 55 60
Arg Asn Glu Gln Phe Arg Cys Ala Gly Val Phe Val Ile Arg Arg Val
65 70 75 80
Ile Glu Pro Gln Gly Leu Val Val Pro Arg Tyr Ser Asn Thr Pro Ala
85 90 95
Leu Ala Tyr Ile Ile Gln Gly Lys Gly Tyr Val Gly Leu Thr Phe Pro
100 105 110
Gly Cys Pro Ala Thr His Gln Gln Gln Phe Gln Leu Phe Glu Gln Arg
115 120 125
Gln Ser Asp Gln Ala His Lys Phe Arg Asp Glu His Gln Lys Ile His
130 135 140
Glu Phe Arg Gln Gly Asp Val Val Ala Leu Pro Ala Ser Val Ala His
145 150 155 160
Trp Phe Tyr Asn Gly Gly Asp Thr Pro Ala Val Val Val Tyr Val Tyr
165 170 175
Asp Ile Lys Ser Phe Ala Asn Gln Leu Glu Pro Arg Gln Lys Glu Phe
180 185 190
Leu Leu Ala Gly Asn Asn Gln Arg Gly Gln Gln Ile Phe Glu His Ser
195 200 205
Ile Phe Gln His Ser Gly Gln Asn Ile Phe Ser Gly Phe Asn Thr Glu
210 215 220
Val Leu Ser Glu Ala Leu Gly Ile Asn Thr Glu Ala Ser Lys Arg Leu
225 230 235 240
Gln Ser Gln Asn Asp Gln Arg Gly Asp Ile Ile Arg Val Lys His Gly
245 250 255
Leu Gln Leu Leu Lys Pro Thr Leu Thr Gln Arg Gln Glu Glu His Arg
260 265 270
Gln Tyr Gln Gln Val Gln Tyr Arg Glu Gly Gln Tyr Asn Gly Leu Asp
275 280 285
Glu Asn Phe Cys Thr Ile Lys Ala Arg Val Asn Ile Glu Asn Pro Ser
290 295 300
Arg Ala Asp Tyr Tyr Asn Pro Arg Ala Gly Arg Ile Thr Leu Leu Asn
305 310 315 320
Asn Gln Lys Phe Pro Ile Leu Asn Leu Ile Gly Met Gly Ala Ala Arg
325 330 335
Val Asn Leu Tyr Gln Asn Ala Leu Leu Ser Pro Phe Trp Asn Ile Asn
340 345 350
Ala His Ser Val Val Tyr Ile Ile Gln Gly Ser Val Arg Val Gln Val
355 360 365
Ala Asn Asn Gln Gly Arg Ser Val Phe Asn Gly Val Leu His Gln Gly
370 375 380
Gln Leu Leu Ile Ile Pro Gln Asn His Ala Val Ile Lys Lys Ala Glu
385 390 395 400
His Asn Gly Cys Gln Tyr Val Ala Ile Lys Thr Ile Ser Asp Pro Thr
405 410 415
Val Ser Trp Val Ala Gly Lys Asn Ser Ile Leu Arg Ala Leu Pro Val
420 425 430
Asp Val Ile Ala Asn Ala Tyr Arg Ile Ser Arg Asp Glu Ala Arg Arg
435 440 445
Leu Lys Asn Asn Arg Ala Asp Glu Ile Gly Pro Phe Thr Pro Arg Phe
450 455 460
Pro Gln Lys Ser Gln Arg Gly Tyr Gln Phe Leu Thr Glu Gly Leu Ser
465 470 475 480
Leu Ile Gly Met
<210> 7
<211> 510
<212> PRT
<213> 水稻
<400> 7
Met Ala Ser Met Ser Thr Ile Leu Pro Leu Cys Leu Gly Leu Leu Leu
1 5 10 15
Phe Phe Gln Val Ser Met Ala Gln Phe Ser Phe Gly Gly Ser Pro Leu
20 25 30
Gln Ser Pro Arg Gly Phe Arg Gly Asp Gln Asp Ser Arg His Gln Cys
35 40 45
Arg Phe Glu His Leu Thr Ala Leu Glu Ala Thr His Gln Gln Arg Ser
50 55 60
Glu Ala Gly Phe Thr Glu Tyr Tyr Asn Ile Glu Ala Arg Asn Glu Phe
65 70 75 80
Arg Cys Ala Gly Val Ser Val Arg Arg Leu Val Val Glu Ser Lys Gly
85 90 95
Leu Val Leu Pro Met Tyr Ala Asn Ala His Lys Leu Val Tyr Ile Val
100 105 110
Gln Gly Arg Gly Val Phe Gly Met Ala Leu Pro Gly Cys Pro Glu Thr
115 120 125
Phe Gln Ser Val Arg Ser Pro Phe Glu Gln Glu Val Ala Thr Ala Gly
130 135 140
Glu Ala Gln Ser Ser Ile Gln Lys Met Arg Asp Glu His Gln Gln Leu
145 150 155 160
His Gln Phe His Gln Gly Asp Val Ile Ala Val Pro Ala Gly Val Ala
165 170 175
His Trp Leu Tyr Asn Asn Gly Asp Ser Pro Val Val Ala Phe Thr Val
180 185 190
Ile Asp Thr Ser Asn Asn Ala Asn Gln Leu Asp Pro Lys Arg Arg Glu
195 200 205
Phe Phe Leu Ala Gly Lys Pro Arg Ser Ser Trp Gln Gln Gln Ser Tyr
210 215 220
Ser Tyr Gln Thr Glu Gln Leu Ser Arg Asn Gln Asn Ile Phe Ala Gly
225 230 235 240
Phe Ser Pro Asp Leu Leu Ser Glu Ala Leu Ser Val Ser Lys Gln Thr
245 250 255
Val Leu Arg Leu Gln Gly Leu Ser Asp Pro Arg Gly Ala Ile Ile Arg
260 265 270
Val Glu Asn Gly Leu Gln Ala Leu Gln Pro Ser Leu Gln Val Glu Pro
275 280 285
Val Lys Glu Glu Gln Thr Gln Ala Tyr Leu Pro Thr Lys Gln Leu Gln
290 295 300
Pro Thr Trp Leu Arg Ser Gly Gly Ala Cys Gly Gln Gln Asn Val Leu
305 310 315 320
Asp Glu Ile Met Cys Ala Phe Lys Leu Arg Lys Asn Ile Asp Asn Pro
325 330 335
Gln Ser Ser Asp Ile Phe Asn Pro His Gly Gly Arg Ile Thr Arg Ala
340 345 350
Asn Ser Gln Asn Phe Pro Ile Leu Asn Ile Ile Gln Met Ser Ala Thr
355 360 365
Arg Ile Val Leu Gln Asn Asn Ala Leu Leu Thr Pro His Trp Thr Val
370 375 380
Asn Ala His Thr Val Met Tyr Val Thr Ala Gly Gln Gly His Ile Gln
385 390 395 400
Val Val Asp His Arg Gly Arg Ser Val Phe Asp Gly Glu Leu His Gln
405 410 415
Gln Gln Ile Leu Leu Ile Pro Gln Asn Phe Ala Val Val Val Lys Ala
420 425 430
Arg Arg Glu Gly Phe Ala Trp Val Ser Phe Lys Thr Asn His Asn Ala
435 440 445
Val Asp Ser Gln Ile Ala Gly Lys Ala Ser Ile Leu Arg Ala Leu Pro
450 455 460
Val Asp Val Val Ala Asn Ala Tyr Arg Leu Ser Arg Glu Asp Ser Arg
465 470 475 480
His Val Lys Phe Asn Arg Gly Asp Glu Met Ala Val Phe Ala Pro Arg
485 490 495
Arg Gly Pro Gln Gln Tyr Ala Glu Trp Gln Ile Asn Glu Lys
500 505 510
<210> 8
<211> 386
<212> PRT
<213> 豌豆
<400> 8
Met Ala Thr Thr Ile Lys Ser Arg Phe Pro Leu Leu Leu Leu Leu Gly
1 5 10 15
Ile Ile Phe Leu Ala Ser Val Val Ser Val Thr Tyr Ala Asn Tyr Asp
20 25 30
Glu Gly Ser Glu Pro Arg Val Pro Ala Gln Arg Glu Arg Gly Arg Gln
35 40 45
Glu Gly Glu Lys Glu Glu Lys Arg His Gly Glu Trp Arg Pro Ser Tyr
50 55 60
Glu Lys Glu Glu Asp Glu Glu Glu Gly Gln Arg Glu Arg Gly Arg Gln
65 70 75 80
Glu Gly Glu Lys Glu Glu Lys Arg His Gly Glu Trp Gly Pro Ser Tyr
85 90 95
Glu Lys Gln Glu Asp Glu Glu Glu Lys Gln Lys Tyr Arg Tyr Gln Arg
100 105 110
Glu Lys Glu Asp Glu Glu Glu Lys Gln Lys Tyr Gln Tyr Gln Arg Glu
115 120 125
Lys Lys Glu Gln Lys Glu Val Gln Pro Gly Arg Glu Arg Trp Glu Arg
130 135 140
Glu Glu Asp Glu Glu Gln Val Asp Glu Glu Trp Arg Gly Ser Gln Arg
145 150 155 160
Arg Glu Asp Pro Glu Glu Arg Ala Arg Leu Arg His Arg Glu Glu Arg
165 170 175
Thr Lys Arg Asp Arg Arg His Gln Arg Glu Gly Glu Glu Glu Glu Arg
180 185 190
Ser Ser Glu Ser Gln Glu Arg Arg Asn Pro Phe Leu Phe Lys Ser Asn
195 200 205
Lys Phe Leu Thr Leu Phe Glu Asn Glu Asn Gly His Ile Arg Leu Leu
210 215 220
Gln Arg Phe Asp Lys Arg Ser Asp Leu Phe Glu Asn Leu Gln Asn Tyr
225 230 235 240
Arg Leu Val Glu Tyr Arg Ala Lys Pro His Thr Ile Phe Leu Pro Gln
245 250 255
His Ile Asp Ala Asp Leu Ile Leu Val Val Leu Ser Gly Lys Ala Ile
260 265 270
Leu Thr Val Leu Ser Pro Asn Asp Arg Asn Ser Tyr Asn Leu Glu Arg
275 280 285
Gly Asp Thr Ile Lys Leu Pro Ala Gly Thr Thr Ser Tyr Leu Val Asn
290 295 300
Gln Asp Asp Glu Glu Asp Leu Arg Leu Val Asp Leu Val Ile Pro Val
305 310 315 320
Asn Gly Pro Gly Lys Phe Glu Ala Phe Asp Leu Ala Lys Asn Lys Asn
325 330 335
Gln Tyr Leu Arg Gly Phe Ser Lys Asn Ile Leu Glu Ala Ser Tyr Asn
340 345 350
Thr Arg Tyr Glu Thr Ile Glu Lys Val Leu Leu Glu Glu Gln Glu Lys
355 360 365
Asp Arg Lys Arg Arg Gln Gln Gly Glu Glu Thr Asp Ala Ile Val Lys
370 375 380
Val Ser
385
<210> 9
<211> 386
<212> PRT
<213> 豌豆
<400> 9
Met Ala Thr Thr Ile Lys Ser Arg Phe Pro Leu Leu Leu Leu Leu Gly
1 5 10 15
Ile Ile Phe Leu Ala Ser Val Val Ser Val Thr Tyr Ala Asn Tyr Asp
20 25 30
Glu Gly Ser Glu Pro Arg Val Pro Ala Gln Arg Glu Arg Gly Arg Gln
35 40 45
Glu Gly Glu Lys Glu Glu Lys Arg His Gly Glu Trp Arg Pro Ser Tyr
50 55 60
Glu Lys Glu Glu Asp Glu Glu Glu Gly Gln Arg Glu Arg Gly Arg Gln
65 70 75 80
Glu Gly Glu Lys Glu Glu Lys Arg His Gly Glu Trp Gly Pro Ser Tyr
85 90 95
Glu Lys Gln Glu Asp Glu Glu Glu Lys Gln Lys Tyr Arg Tyr Gln Arg
100 105 110
Glu Lys Glu Asp Glu Glu Glu Lys Gln Lys Tyr Gln Tyr Gln Arg Glu
115 120 125
Lys Lys Glu Gln Lys Glu Val Gln Pro Gly Arg Glu Arg Trp Glu Arg
130 135 140
Glu Glu Asp Glu Glu Gln Val Asp Glu Glu Trp Arg Gly Ser Gln Arg
145 150 155 160
Arg Glu Asp Pro Glu Glu Arg Ala Arg Leu Arg His Arg Glu Glu Arg
165 170 175
Thr Lys Arg Asp Arg Arg His Gln Arg Glu Gly Glu Glu Glu Glu Arg
180 185 190
Ser Ser Glu Ser Gln Glu Arg Arg Asn Pro Phe Leu Phe Lys Ser Asn
195 200 205
Lys Phe Leu Thr Leu Phe Glu Asn Glu Asn Gly His Ile Arg Leu Leu
210 215 220
Gln Arg Phe Asp Lys Arg Ser Asp Leu Phe Glu Asn Leu Gln Asn Tyr
225 230 235 240
Arg Leu Val Glu Tyr Arg Ala Lys Pro His Thr Ile Phe Leu Pro Gln
245 250 255
His Ile Asp Ala Asp Leu Ile Leu Val Val Leu Ser Gly Lys Ala Ile
260 265 270
Leu Thr Val Leu Ser Pro Asn Asp Arg Asn Ser Tyr Asn Leu Glu Arg
275 280 285
Gly Asp Thr Ile Lys Leu Pro Ala Gly Thr Thr Ser Tyr Leu Val Asn
290 295 300
Gln Asp Asp Glu Glu Asp Leu Arg Leu Val Asp Leu Val Ile Pro Val
305 310 315 320
Asn Gly Pro Gly Lys Phe Glu Ala Phe Asp Leu Ala Lys Asn Lys Asn
325 330 335
Gln Tyr Leu Arg Gly Phe Ser Lys Asn Ile Leu Glu Ala Ser Tyr Asn
340 345 350
Thr Arg Tyr Glu Thr Ile Glu Lys Val Leu Leu Glu Glu Gln Glu Lys
355 360 365
Asp Arg Lys Arg Arg Gln Gln Gly Glu Glu Thr Asp Ala Ile Val Lys
370 375 380
Val Ser
385
<210> 10
<211> 499
<212> PRT
<213> 水稻
<400> 10
Met Ala Ser Ser Val Phe Ser Arg Phe Ser Ile Tyr Phe Cys Val Leu
1 5 10 15
Leu Leu Cys His Gly Ser Met Ala Gln Leu Phe Asn Pro Ser Thr Asn
20 25 30
Pro Trp His Ser Pro Arg Gln Gly Ser Phe Arg Glu Cys Arg Phe Asp
35 40 45
Arg Leu Gln Ala Phe Glu Pro Leu Arg Lys Val Arg Ser Glu Ala Gly
50 55 60
Val Thr Glu Tyr Phe Asp Glu Lys Asn Glu Leu Phe Gln Cys Thr Gly
65 70 75 80
Thr Phe Val Ile Arg Arg Val Ile Gln Pro Gln Gly Leu Leu Val Pro
85 90 95
Arg Tyr Thr Asn Ile Pro Gly Val Val Tyr Ile Ile Gln Gly Arg Gly
100 105 110
Ser Met Gly Leu Thr Phe Pro Gly Cys Pro Ala Thr Tyr Gln Gln Gln
115 120 125
Phe Gln Gln Phe Ser Ser Gln Gly Gln Ser Gln Ser Gln Lys Phe Arg
130 135 140
Asp Glu His Gln Lys Ile His Gln Phe Arg Gln Gly Asp Ile Val Ala
145 150 155 160
Leu Pro Ala Gly Val Ala His Trp Phe Tyr Asn Asp Gly Asp Ala Pro
165 170 175
Ile Val Ala Val Tyr Val Tyr Asp Val Asn Asn Asn Ala Asn Gln Leu
180 185 190
Glu Pro Arg Gln Lys Glu Phe Leu Leu Ala Gly Asn Asn Asn Arg Ala
195 200 205
Gln Gln Gln Gln Val Tyr Gly Ser Ser Ile Glu Gln His Ser Gly Gln
210 215 220
Asn Ile Phe Ser Gly Phe Gly Val Glu Met Leu Ser Glu Ala Leu Gly
225 230 235 240
Ile Asn Ala Val Ala Ala Lys Arg Leu Gln Ser Gln Asn Asp Gln Arg
245 250 255
Gly Glu Ile Ile His Val Lys Asn Gly Leu Gln Leu Leu Lys Pro Thr
260 265 270
Leu Thr Gln Gln Gln Glu Gln Ala Gln Ala Gln Asp Gln Tyr Gln Gln
275 280 285
Val Gln Tyr Ser Glu Arg Gln Gln Thr Ser Ser Arg Trp Asn Gly Leu
290 295 300
Glu Glu Asn Phe Cys Thr Ile Lys Val Arg Val Asn Ile Glu Asn Pro
305 310 315 320
Ser Arg Ala Asp Ser Tyr Asn Pro Arg Ala Gly Arg Ile Thr Ser Val
325 330 335
Asn Ser Gln Lys Phe Pro Ile Leu Asn Leu Ile Gln Met Ser Ala Thr
340 345 350
Arg Val Asn Leu Tyr Gln Asn Ala Ile Leu Ser Pro Phe Trp Asn Val
355 360 365
Asn Ala His Ser Leu Val Tyr Met Ile Gln Gly Arg Ser Arg Val Gln
370 375 380
Val Val Ser Asn Phe Gly Lys Thr Val Phe Asp Gly Val Leu Arg Pro
385 390 395 400
Gly Gln Leu Leu Ile Ile Pro Gln His Tyr Ala Val Leu Lys Lys Ala
405 410 415
Glu Arg Glu Gly Cys Gln Tyr Ile Ala Ile Lys Thr Asn Ala Asn Ala
420 425 430
Phe Val Ser His Leu Ala Gly Lys Asn Ser Val Phe Arg Ala Leu Pro
435 440 445
Val Asp Val Val Ala Asn Ala Tyr Arg Ile Ser Arg Glu Gln Ala Arg
450 455 460
Ser Leu Lys Asn Asn Arg Gly Glu Glu His Gly Ala Phe Thr Pro Arg
465 470 475 480
Phe Gln Gln Gln Tyr Tyr Pro Gly Leu Ser Asn Glu Ser Glu Ser Glu
485 490 495
Thr Ser Glu
<210> 11
<211> 499
<212> PRT
<213> 水稻
<400> 11
Met Ala Ser Ile Asn Arg Pro Ile Val Phe Phe Thr Val Cys Leu Phe
1 5 10 15
Leu Leu Cys Asn Gly Ser Leu Ala Gln Gln Leu Leu Gly Gln Ser Thr
20 25 30
Ser Gln Trp Gln Ser Ser Arg Arg Gly Ser Pro Arg Glu Cys Arg Phe
35 40 45
Asp Arg Leu Gln Ala Phe Glu Pro Ile Arg Ser Val Arg Ser Gln Ala
50 55 60
Gly Thr Thr Glu Phe Phe Asp Val Ser Asn Glu Gln Phe Gln Cys Thr
65 70 75 80
Gly Val Ser Val Val Arg Arg Val Ile Glu Pro Arg Gly Leu Leu Leu
85 90 95
Pro His Tyr Thr Asn Gly Ala Ser Leu Val Tyr Ile Ile Gln Gly Arg
100 105 110
Gly Ile Thr Gly Pro Thr Phe Pro Gly Cys Pro Glu Ser Tyr Gln Gln
115 120 125
Gln Phe Gln Gln Ser Gly Gln Ala Gln Leu Thr Glu Ser Gln Ser Gln
130 135 140
Ser Gln Lys Phe Lys Asp Glu His Gln Lys Ile His Arg Phe Arg Gln
145 150 155 160
Gly Asp Val Ile Ala Leu Pro Ala Gly Val Ala His Trp Cys Tyr Asn
165 170 175
Asp Gly Glu Val Pro Val Val Ala Ile Tyr Val Thr Asp Leu Asn Asn
180 185 190
Gly Ala Asn Gln Leu Asp Pro Arg Gln Arg Asp Phe Leu Leu Ala Gly
195 200 205
Asn Lys Arg Asn Pro Gln Ala Tyr Arg Arg Glu Val Glu Glu Arg Ser
210 215 220
Gln Asn Ile Phe Ser Gly Phe Ser Thr Glu Leu Leu Ser Glu Ala Leu
225 230 235 240
Gly Val Ser Ser Gln Val Ala Arg Gln Leu Gln Cys Gln Asn Asp Gln
245 250 255
Arg Gly Glu Ile Val Arg Val Glu His Gly Leu Ser Leu Leu Gln Pro
260 265 270
Tyr Ala Ser Leu Gln Glu Gln Glu Gln Gly Gln Val Gln Ser Arg Glu
275 280 285
Arg Tyr Gln Glu Gly Gln Tyr Gln Gln Ser Gln Tyr Gly Ser Gly Cys
290 295 300
Ser Asn Gly Leu Asp Glu Thr Phe Cys Thr Leu Arg Val Arg Gln Asn
305 310 315 320
Ile Asp Asn Pro Asn Arg Ala Asp Thr Tyr Asn Pro Arg Ala Gly Arg
325 330 335
Val Thr Asn Leu Asn Thr Gln Asn Phe Pro Ile Leu Ser Leu Val Gln
340 345 350
Met Ser Ala Val Lys Val Asn Leu Tyr Gln Asn Ala Leu Leu Ser Pro
355 360 365
Phe Trp Asn Ile Asn Ala His Ser Val Val Tyr Ile Thr Gln Gly Arg
370 375 380
Ala Arg Val Gln Val Val Asn Asn Asn Gly Lys Thr Val Phe Asn Gly
385 390 395 400
Glu Leu Arg Arg Gly Gln Leu Leu Ile Ile Pro Gln His Tyr Ala Val
405 410 415
Val Lys Lys Ala Gln Arg Glu Gly Cys Ala Tyr Ile Ala Phe Lys Thr
420 425 430
Asn Pro Asn Ser Met Val Ser His Ile Ala Gly Lys Ser Ser Ile Phe
435 440 445
Arg Ala Leu Pro Asn Asp Val Leu Ala Asn Ala Tyr Arg Ile Ser Arg
450 455 460
Glu Glu Ala Gln Arg Leu Lys His Asn Arg Gly Asp Glu Phe Gly Ala
465 470 475 480
Phe Thr Pro Ile Gln Tyr Lys Ser Tyr Gln Asp Val Tyr Asn Ala Ala
485 490 495
Glu Ser Ser
<210> 12
<211> 499
<212> PRT
<213> 水稻
<400> 12
Met Ala Ser Ile Asn Arg Pro Ile Val Phe Phe Thr Val Cys Leu Phe
1 5 10 15
Leu Leu Cys Asp Gly Ser Leu Ala Gln Gln Leu Leu Gly Gln Ser Thr
20 25 30
Ser Gln Trp Gln Ser Ser Arg Arg Gly Ser Pro Arg Gly Cys Arg Phe
35 40 45
Asp Arg Leu Gln Ala Phe Glu Pro Ile Arg Ser Val Arg Ser Gln Ala
50 55 60
Gly Thr Thr Glu Phe Phe Asp Val Ser Asn Glu Leu Phe Gln Cys Thr
65 70 75 80
Gly Val Ser Val Val Arg Arg Val Ile Glu Pro Arg Gly Leu Leu Leu
85 90 95
Pro His Tyr Thr Asn Gly Ala Ser Leu Val Tyr Ile Ile Gln Gly Arg
100 105 110
Gly Ile Thr Gly Pro Thr Phe Pro Gly Cys Pro Glu Thr Tyr Gln Gln
115 120 125
Gln Phe Gln Gln Ser Gly Gln Ala Gln Leu Thr Glu Ser Gln Ser Gln
130 135 140
Ser His Lys Phe Lys Asp Glu His Gln Lys Ile His Arg Phe Arg Gln
145 150 155 160
Gly Asp Val Ile Ala Leu Pro Ala Gly Val Ala His Trp Cys Tyr Asn
165 170 175
Asp Gly Glu Val Pro Val Val Ala Ile Tyr Val Thr Asp Ile Asn Asn
180 185 190
Gly Ala Asn Gln Leu Asp Pro Arg Gln Arg Asp Phe Leu Leu Ala Gly
195 200 205
Asn Lys Arg Asn Pro Gln Ala Tyr Arg Arg Glu Val Glu Glu Trp Ser
210 215 220
Gln Asn Ile Phe Ser Gly Phe Ser Thr Glu Leu Leu Ser Glu Ala Phe
225 230 235 240
Gly Ile Ser Asn Gln Val Ala Arg Gln Leu Gln Cys Gln Asn Asp Gln
245 250 255
Arg Gly Glu Ile Val Arg Val Glu Arg Gly Leu Ser Leu Leu Gln Pro
260 265 270
Tyr Ala Ser Leu Gln Glu Gln Glu Gln Gly Gln Met Gln Ser Arg Glu
275 280 285
His Tyr Gln Glu Gly Gly Tyr Gln Gln Ser Gln Tyr Gly Ser Gly Cys
290 295 300
Pro Asn Gly Leu Asp Glu Thr Phe Cys Thr Met Arg Val Arg Gln Asn
305 310 315 320
Ile Asp Asn Pro Asn Arg Ala Asp Thr Tyr Asn Pro Arg Ala Gly Arg
325 330 335
Val Thr Asn Leu Asn Ser Gln Asn Phe Pro Ile Leu Asn Leu Val Gln
340 345 350
Met Ser Ala Val Lys Val Asn Leu Tyr Gln Asn Ala Leu Leu Ser Pro
355 360 365
Phe Trp Asn Ile Asn Ala His Ser Ile Val Tyr Ile Thr Gln Gly Arg
370 375 380
Ala Gln Val Gln Val Val Asn Asn Asn Gly Lys Thr Val Phe Asn Gly
385 390 395 400
Glu Leu Arg Arg Gly Gln Leu Leu Ile Val Pro Gln His Tyr Val Val
405 410 415
Val Lys Lys Ala Gln Arg Glu Gly Cys Ala Tyr Ile Ala Phe Lys Thr
420 425 430
Asn Pro Asn Ser Met Val Ser His Ile Ala Gly Lys Ser Ser Ile Phe
435 440 445
Arg Ala Leu Pro Thr Asp Val Leu Ala Asn Ala Tyr Arg Ile Ser Arg
450 455 460
Glu Glu Ala Gln Arg Leu Lys His Asn Arg Gly Asp Glu Phe Gly Ala
465 470 475 480
Phe Thr Pro Leu Gln Tyr Lys Ser Tyr Gln Asp Val Tyr Asn Val Ala
485 490 495
Glu Ser Ser
<210> 13
<211> 160
<212> PRT
<213> 水稻
<400> 13
Met Ala Ser Asn Lys Val Val Phe Ser Val Leu Leu Leu Ala Val Val
1 5 10 15
Ser Val Leu Ala Ala Thr Ala Thr Met Ala Glu Tyr His His Gln Asp
20 25 30
Gln Val Val Tyr Thr Pro Gly Pro Leu Cys Gln Pro Gly Met Gly Tyr
35 40 45
Pro Met Tyr Pro Leu Pro Arg Cys Arg Ala Leu Val Lys Arg Gln Cys
50 55 60
Val Gly Arg Gly Thr Ala Ala Ala Ala Glu Gln Val Arg Arg Asp Cys
65 70 75 80
Cys Arg Gln Leu Ala Ala Val Asp Asp Ser Trp Cys Arg Cys Glu Ala
85 90 95
Ile Ser His Met Leu Gly Gly Ile Tyr Arg Glu Leu Gly Ala Pro Asp
100 105 110
Val Gly His Pro Met Ser Glu Val Phe Arg Gly Cys Arg Arg Gly Asp
115 120 125
Leu Glu Arg Ala Ala Ala Ser Leu Pro Ala Phe Cys Asn Val Asp Ile
130 135 140
Pro Asn Gly Gly Gly Gly Val Cys Tyr Trp Leu Ala Arg Ser Gly Tyr
145 150 155 160
<210> 14
<211> 500
<212> PRT
<213> 水稻
<400> 14
Met Ala Thr Ile Ala Phe Ser Arg Leu Ser Ile Tyr Phe Cys Val Leu
1 5 10 15
Leu Leu Cys His Gly Ser Met Ala Gln Leu Phe Gly Pro Asn Val Asn
20 25 30
Pro Trp His Asn Pro Arg Gln Gly Gly Phe Arg Glu Cys Arg Phe Asp
35 40 45
Arg Leu Gln Ala Phe Glu Pro Leu Arg Arg Val Arg Ser Glu Ala Gly
50 55 60
Val Thr Glu Tyr Phe Asp Glu Lys Asn Glu Gln Phe Gln Cys Thr Gly
65 70 75 80
Thr Phe Val Ile Arg Arg Val Ile Glu Pro Gln Gly Leu Leu Val Pro
85 90 95
Arg Tyr Ser Asn Thr Pro Gly Met Val Tyr Ile Ile Gln Gly Arg Gly
100 105 110
Ser Met Gly Leu Thr Phe Pro Gly Cys Pro Ala Thr Tyr Gln Gln Gln
115 120 125
Phe Gln Gln Phe Leu Pro Glu Gly Gln Ser Gln Ser Gln Lys Phe Arg
130 135 140
Asp Glu His Gln Lys Ile His Gln Phe Arg Gln Gly Asp Ile Val Ala
145 150 155 160
Leu Pro Ala Gly Val Ala His Trp Phe Tyr Asn Glu Gly Asp Ala Pro
165 170 175
Val Val Ala Leu Tyr Val Phe Asp Leu Asn Asn Asn Ala Asn Gln Leu
180 185 190
Glu Pro Arg Gln Lys Glu Phe Leu Leu Ala Gly Asn Asn Asn Arg Glu
195 200 205
Gln Gln Met Tyr Gly Arg Ser Ile Glu Gln His Ser Gly Gln Asn Ile
210 215 220
Phe Ser Gly Phe Asn Asn Glu Leu Leu Ser Glu Ala Leu Gly Val Asn
225 230 235 240
Ala Leu Val Ala Lys Arg Leu Gln Gly Gln Asn Asp Gln Arg Gly Glu
245 250 255
Ile Ile Arg Val Lys Asn Gly Leu Lys Leu Leu Arg Pro Ala Phe Ala
260 265 270
Gln Gln Gln Glu Gln Ala Gln Gln Gln Glu Gln Ala Gln Ala Gln Tyr
275 280 285
Gln Val Gln Tyr Ser Glu Glu Gln Gln Pro Ser Thr Arg Cys Asn Gly
290 295 300
Leu Asp Glu Asn Phe Cys Thr Ile Lys Ala Arg Leu Asn Ile Glu Asn
305 310 315 320
Pro Ser His Ala Asp Thr Tyr Asn Pro Arg Ala Gly Arg Ile Thr Arg
325 330 335
Leu Asn Ser Gln Lys Phe Pro Ile Leu Asn Leu Val Gln Leu Ser Ala
340 345 350
Thr Arg Val Asn Leu Tyr Gln Asn Ala Ile Leu Ser Pro Phe Trp Asn
355 360 365
Val Asn Ala His Ser Leu Val Tyr Ile Val Gln Gly His Ala Arg Val
370 375 380
Gln Val Val Ser Asn Leu Gly Lys Thr Val Phe Asn Gly Val Leu Arg
385 390 395 400
Pro Gly Gln Leu Leu Ile Ile Pro Gln His Tyr Val Val Leu Lys Lys
405 410 415
Ala Glu His Glu Gly Cys Gln Tyr Ile Ser Phe Lys Thr Asn Ala Asn
420 425 430
Ser Met Val Ser His Leu Ala Gly Lys Asn Ser Ile Phe Arg Ala Met
435 440 445
Pro Val Asp Val Ile Ala Asn Ala Tyr Arg Ile Ser Arg Glu Gln Ala
450 455 460
Arg Ser Leu Lys Asn Asn Arg Gly Glu Glu Leu Gly Ala Phe Thr Pro
465 470 475 480
Arg Tyr Gln Gln Gln Thr Tyr Pro Gly Phe Ser Asn Glu Ser Glu Asn
485 490 495
Glu Ala Leu Glu
500
<210> 15
<211> 609
<212> PRT
<213> 水稻
<400> 15
Met Ser Ala Leu Thr Thr Ser Gln Leu Ala Thr Ser Ala Thr Gly Phe
1 5 10 15
Gly Ile Ala Asp Arg Ser Ala Pro Ser Ser Leu Leu Arg His Gly Phe
20 25 30
Gln Gly Leu Lys Pro Arg Ser Pro Ala Gly Gly Asp Ala Thr Ser Leu
35 40 45
Ser Val Thr Thr Ser Ala Arg Ala Thr Pro Lys Gln Gln Arg Ser Val
50 55 60
Gln Arg Gly Ser Arg Arg Phe Pro Ser Val Val Val Tyr Ala Thr Gly
65 70 75 80
Ala Gly Met Asn Val Val Phe Val Gly Ala Glu Met Ala Pro Trp Ser
85 90 95
Lys Thr Gly Gly Leu Gly Asp Val Leu Gly Gly Leu Pro Pro Ala Met
100 105 110
Ala Ala Asn Gly His Arg Val Met Val Ile Ser Pro Arg Tyr Asp Gln
115 120 125
Tyr Lys Asp Ala Trp Asp Thr Ser Val Val Ala Glu Ile Lys Val Ala
130 135 140
Asp Arg Tyr Glu Arg Val Arg Phe Phe His Cys Tyr Lys Arg Gly Val
145 150 155 160
Asp Arg Val Phe Ile Asp His Pro Ser Phe Leu Glu Lys Val Trp Gly
165 170 175
Lys Thr Gly Glu Lys Ile Tyr Gly Pro Asp Thr Gly Val Asp Tyr Lys
180 185 190
Asp Asn Gln Met Arg Phe Ser Leu Leu Cys Gln Ala Ala Leu Glu Ala
195 200 205
Pro Arg Ile Leu Asn Leu Asn Asn Asn Pro Tyr Phe Lys Gly Thr Tyr
210 215 220
Gly Glu Asp Val Val Phe Val Cys Asn Asp Trp His Thr Gly Pro Leu
225 230 235 240
Ala Ser Tyr Leu Lys Asn Asn Tyr Gln Pro Asn Gly Ile Tyr Arg Asn
245 250 255
Ala Lys Val Ala Phe Cys Ile His Asn Ile Ser Tyr Gln Gly Arg Phe
260 265 270
Ala Phe Glu Asp Tyr Pro Glu Leu Asn Leu Ser Glu Arg Phe Arg Ser
275 280 285
Ser Phe Asp Phe Ile Asp Gly Tyr Asp Thr Pro Val Glu Gly Arg Lys
290 295 300
Ile Asn Trp Met Lys Ala Gly Ile Leu Glu Ala Asp Arg Val Leu Thr
305 310 315 320
Val Ser Pro Tyr Tyr Ala Glu Glu Leu Ile Ser Gly Ile Ala Arg Gly
325 330 335
Cys Glu Leu Asp Asn Ile Met Arg Leu Thr Gly Ile Thr Gly Ile Val
340 345 350
Asn Gly Met Asp Val Ser Glu Trp Asp Pro Ser Lys Asp Lys Tyr Ile
355 360 365
Thr Ala Lys Tyr Asp Ala Thr Thr Ala Ile Glu Ala Lys Ala Leu Asn
370 375 380
Lys Glu Ala Leu Gln Ala Glu Ala Gly Leu Pro Val Asp Arg Lys Ile
385 390 395 400
Pro Leu Ile Ala Phe Ile Gly Arg Leu Glu Glu Gln Lys Gly Pro Asp
405 410 415
Val Met Ala Ala Ala Ile Pro Glu Leu Met Gln Glu Asp Val Gln Ile
420 425 430
Val Leu Leu Gly Thr Gly Lys Lys Lys Phe Glu Lys Leu Leu Lys Ser
435 440 445
Met Glu Glu Lys Tyr Pro Gly Lys Val Arg Ala Val Val Lys Phe Asn
450 455 460
Ala Pro Leu Ala His Leu Ile Met Ala Gly Ala Asp Val Leu Ala Val
465 470 475 480
Pro Ser Arg Phe Glu Pro Cys Gly Leu Ile Gln Leu Gln Gly Met Arg
485 490 495
Tyr Gly Thr Pro Cys Ala Cys Ala Ser Thr Gly Gly Leu Val Asp Thr
500 505 510
Val Ile Glu Gly Lys Thr Gly Phe His Met Gly Arg Leu Ser Val Asp
515 520 525
Cys Lys Val Val Glu Pro Ser Asp Val Lys Lys Val Ala Ala Thr Leu
530 535 540
Lys Arg Ala Ile Lys Val Val Gly Thr Pro Ala Tyr Glu Glu Met Val
545 550 555 560
Arg Asn Cys Met Asn Gln Asp Leu Ser Trp Lys Gly Pro Ala Lys Asn
565 570 575
Trp Glu Asn Val Leu Leu Gly Leu Gly Val Ala Gly Ser Ala Pro Gly
580 585 590
Ile Glu Gly Asp Glu Ile Ala Pro Leu Ala Lys Glu Asn Val Ala Ala
595 600 605
Pro
<210> 16
<211> 336
<212> PRT
<213> 金黄色葡萄球菌
<400> 16
Met Lys Gly Lys Phe Leu Lys Val Ser Ser Leu Phe Val Ala Thr Leu
1 5 10 15
Thr Thr Ala Thr Leu Val Ser Ser Pro Ala Ala Asn Ala Leu Ser Ser
20 25 30
Lys Ala Met Asp Asn His Pro Gln Gln Thr Gln Ser Ser Lys Gln Gln
35 40 45
Thr Pro Lys Ile Gln Lys Gly Gly Asn Leu Lys Pro Leu Glu Gln Arg
50 55 60
Glu His Ala Asn Val Ile Leu Pro Asn Asn Asp Arg His Gln Ile Thr
65 70 75 80
Asp Thr Thr Asn Gly His Tyr Ala Pro Val Thr Tyr Ile Gln Val Glu
85 90 95
Ala Pro Thr Gly Thr Phe Ile Ala Ser Gly Val Val Val Gly Lys Asp
100 105 110
Thr Leu Leu Thr Asn Lys His Val Val Asp Ala Thr His Gly Asp Pro
115 120 125
His Ala Leu Lys Ala Phe Pro Ser Ala Ile Asn Gln Asp Asn Tyr Pro
130 135 140
Asn Gly Gly Phe Thr Ala Glu Gln Ile Thr Lys Tyr Ser Gly Glu Gly
145 150 155 160
Asp Leu Ala Ile Val Lys Phe Ser Pro Asn Glu Gln Asn Lys His Ile
165 170 175
Gly Glu Val Val Lys Pro Ala Thr Met Ser Asn Asn Ala Glu Thr Gln
180 185 190
Val Asn Gln Asn Ile Thr Val Thr Gly Tyr Pro Gly Asp Lys Pro Val
195 200 205
Ala Thr Met Trp Glu Ser Lys Gly Lys Ile Thr Tyr Leu Lys Gly Glu
210 215 220
Ala Met Gln Tyr Asp Leu Ser Thr Thr Gly Gly Asn Ser Gly Ser Pro
225 230 235 240
Val Phe Asn Glu Lys Asn Glu Val Ile Gly Ile His Trp Gly Gly Val
245 250 255
Pro Asn Glu Phe Asn Gly Ala Val Phe Ile Asn Glu Asn Val Arg Asn
260 265 270
Phe Leu Lys Gln Asn Ile Glu Asp Ile His Phe Ala Asn Asp Asp Gln
275 280 285
Pro Asn Asn Pro Asp Asn Pro Asp Asn Pro Asn Asn Pro Asp Asn Pro
290 295 300
Asn Asn Pro Asp Glu Pro Asn Asn Pro Asp Asn Pro Asn Asn Pro Asp
305 310 315 320
Asn Pro Asp Asn Gly Asp Asn Asn Asn Ser Asp Asn Pro Asp Ala Ala
325 330 335
<210> 17
<211> 22
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 1的片段
<400> 17
Pro Phe Asn Leu Arg Ser Arg Gly Pro Ile Tyr Ser Asn Glu Phe Gly
1 5 10 15
Lys Phe Phe Glu Ile Thr
20
<210> 18
<211> 17
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 1的片段
<400> 18
Lys Pro Asp Asp Arg Asn Ser Phe Asn Leu Glu Arg Gly Asp Thr Ile
1 5 10 15
Lys
<210> 19
<211> 27
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 1的片段
<400> 19
Tyr Leu Val Asn Arg Asp Asp Asn Glu Glu Leu Arg Val Leu Asp Leu
1 5 10 15
Ala Ile Pro Val Asn Arg Pro Gly Gln Leu Gln
20 25
<210> 20
<211> 51
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 1的片段
<400> 20
Gln Glu Gln Arg Lys Glu Asp Asp Glu Glu Glu Glu Gln Gly Glu Glu
1 5 10 15
Glu Ile Asn Lys Gln Val Gln Asn Tyr Lys Ala Lys Leu Ser Ser Gly
20 25 30
Asp Val Phe Val Ile Pro Ala Gly His Pro Val Ala Val Lys Ala Ser
35 40 45
Ser Asn Leu
50
<210> 21
<211> 68
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 1的片段
<400> 21
Ser Gly Phe Ser Lys Asn Ile Leu Glu Ala Ser Phe Asn Thr Asp Tyr
1 5 10 15
Glu Glu Ile Glu Lys Val Leu Leu Glu Glu His Glu Lys Glu Thr Gln
20 25 30
His Arg Arg Ser Leu Lys Asp Lys Arg Gln Gln Ser Gln Glu Glu Asn
35 40 45
Val Ile Val Lys Leu Ser Arg Gly Gln Ile Glu Glu Leu Ser Lys Asn
50 55 60
Ala Lys Ser Thr
65
<210> 22
<211> 74
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 1的片段
<400> 22
Pro Phe Ile Phe Lys Ser Asn Lys Phe Gln Thr Leu Phe Glu Asn Glu
1 5 10 15
Asn Gly His Ile Arg Leu Leu Gln Lys Phe Asp Gln Arg Ser Lys Ile
20 25 30
Phe Glu Asn Leu Gln Asn Tyr Arg Leu Leu Glu Tyr Lys Ser Lys Pro
35 40 45
His Thr Ile Phe Leu Pro Gln His Thr Asp Ala Asp Tyr Ile Leu Val
50 55 60
Val Leu Ser Gly Lys Ala Ile Leu Thr Val
65 70
<210> 23
<211> 28
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 1的片段
<400> 23
Gln Glu Val Asp Arg Ile Leu Glu Asn Gln Lys Gln Ser His Phe Ala
1 5 10 15
Asp Ala Gln Pro Gln Gln Arg Glu Arg Gly Ser Arg
20 25
<210> 24
<211> 35
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 2的片段
<400> 24
Asn Asn Ser Gly Lys Phe Phe Glu Leu Thr Pro Glu Lys Asn Gln Gln
1 5 10 15
Leu Gln Asp Leu Asp Leu Phe Val Asn Ser Val Asp Leu Lys Glu Gly
20 25 30
Ser Leu Leu
35
<210> 25
<211> 17
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 2的片段
<400> 25
Lys Val Ser Arg Arg Gln Leu Glu Glu Leu Ser Lys Asn Ala Lys Ser
1 5 10 15
Ser
<210> 26
<211> 21
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 3的片段
<400> 26
Gln Arg Gly Ser Arg Gln Glu Glu Asp Glu Asp Glu Asp Glu Glu Arg
1 5 10 15
Gln Pro Arg His Gln
20
<210> 27
<211> 33
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 3的片段
<400> 27
Gln Glu Phe Leu Arg Tyr Gln His Gln Gln Gly Gly Lys Gln Glu Gln
1 5 10 15
Glu Asn Glu Gly Asn Asn Ile Phe Ser Gly Phe Lys Arg Asp Phe Leu
20 25 30
Glu
<210> 28
<211> 34
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 4的片段
<400> 28
Tyr Asn Leu Glu Arg Gly Asp Thr Ile Lys Leu Pro Ala Gly Thr Thr
1 5 10 15
Ser Tyr Leu Val Asn Gln Asp Asp Glu Glu Asp Leu Arg Leu Val Asp
20 25 30
Leu Val
<210> 29
<211> 80
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 4的片段
<400> 29
Asn Gly Pro Gly Lys Phe Glu Ala Phe Asp Leu Ala Lys Asn Lys Asn
1 5 10 15
Gln Tyr Leu Arg Gly Phe Ser Lys Asn Ile Leu Glu Ala Ser Tyr Asn
20 25 30
Thr Arg Tyr Glu Thr Ile Glu Lys Val Leu Leu Glu Glu Gln Glu Lys
35 40 45
Asp Arg Lys Arg Arg Gln Gln Gly Glu Glu Thr Asp Ala Ile Val Lys
50 55 60
Val Ser Arg Glu Gln Ile Glu Glu Leu Lys Lys Leu Ala Lys Ser Ser
65 70 75 80
<210> 30
<211> 47
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 4的片段
<400> 30
Arg Tyr Glu Ala Arg Leu Ser Pro Gly Asp Val Val Ile Ile Pro Ala
1 5 10 15
Gly His Pro Val Ala Ile Thr Ala Ser Ser Asn Leu Asn Leu Leu Gly
20 25 30
Phe Gly Ile Asn Ala Glu Asn Asn Glu Arg Asn Phe Leu Ser Gly
35 40 45
<210> 31
<211> 24
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 4的片段
<400> 31
His Gly Glu Trp Arg Pro Ser Tyr Glu Lys Gln Glu Asp Glu Glu Glu
1 5 10 15
Lys Gln Lys Tyr Arg Tyr Gln Arg
20
<210> 32
<211> 19
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 4的片段
<400> 32
Pro Ser Tyr Glu Lys Glu Glu Asp Glu Glu Glu Gly Gln Arg Glu Arg
1 5 10 15
Gly Arg Gln
<210> 33
<211> 30
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 4的片段
<400> 33
Lys Ser Lys Pro Arg Thr Leu Phe Leu Pro Gln Tyr Thr Asp Ala Asp
1 5 10 15
Phe Ile Leu Val Val Leu Ser Gly Lys Ala Thr Leu Thr Val
20 25 30
<210> 34
<211> 22
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 10的片段
<400> 34
Ser Gln Ser Gln Lys Phe Arg Asp Glu His Gln Lys Ile His Gln Phe
1 5 10 15
Arg Gln Gly Asp Ile Val
20
<210> 35
<211> 23
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 10的片段
<400> 35
Val Asn Ser Gln Lys Phe Pro Ile Leu Asn Leu Ile Gln Met Ser Ala
1 5 10 15
Thr Arg Val Asn Leu Tyr Gln
20
<210> 36
<211> 40
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 10的片段
<400> 36
Tyr Ile Ala Ile Lys Thr Asn Ala Asn Ala Phe Val Ser His Leu Ala
1 5 10 15
Gly Lys Asn Ser Val Phe Arg Ala Leu Pro Val Asp Val Val Ala Asn
20 25 30
Ala Tyr Arg Ile Ser Arg Glu Gln
35 40
<210> 37
<211> 31
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 10的片段
<400> 37
Ala Pro Ile Val Ala Val Tyr Val Tyr Asp Val Asn Asn Asn Ala Asn
1 5 10 15
Gln Leu Glu Pro Arg Gln Lys Glu Phe Leu Leu Ala Gly Asn Asn
20 25 30
<210> 38
<211> 17
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 10的片段
<400> 38
Glu Asn Pro Ser Arg Ala Asp Ser Tyr Asn Pro Arg Ala Gly Arg Ile
1 5 10 15
Thr
<210> 39
<211> 32
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 10的片段
<400> 39
Gly Leu Gln Leu Leu Lys Pro Thr Leu Thr Gln Gln Gln Glu Gln Ala
1 5 10 15
Gln Ala Gln Asp Gln Tyr Gln Gln Val Gln Tyr Ser Glu Arg Gln Gln
20 25 30
<210> 40
<211> 18
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 10的片段
<400> 40
Cys Arg Phe Asp Arg Leu Gln Ala Phe Glu Pro Leu Arg Lys Val Arg
1 5 10 15
Ser Glu
<210> 41
<211> 48
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 10的片段
<400> 41
Ile Leu Ser Pro Phe Trp Asn Val Asn Ala His Ser Leu Val Tyr Met
1 5 10 15
Ile Gln Gly Arg Ser Arg Val Gln Val Val Ser Asn Phe Gly Lys Thr
20 25 30
Val Phe Asp Gly Val Leu Arg Pro Gly Gln Leu Leu Ile Ile Pro Gln
35 40 45
<210> 42
<211> 24
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 10的片段
<400> 42
Ala Phe Thr Pro Arg Phe Gln Gln Gln Tyr Tyr Pro Gly Leu Ser Asn
1 5 10 15
Glu Ser Glu Ser Glu Thr Ser Glu
20
<210> 43
<211> 31
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 11的片段
<400> 43
Pro Arg Ala Gly Arg Val Thr Asn Leu Asn Thr Gln Asn Phe Pro Ile
1 5 10 15
Leu Ser Leu Val Gln Met Ser Ala Val Lys Val Asn Leu Tyr Gln
20 25 30
<210> 44
<211> 32
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 11的片段
<400> 44
His Ser Val Val Tyr Ile Thr Gln Gly Arg Ala Arg Val Gln Val Val
1 5 10 15
Asn Asn Asn Gly Lys Thr Val Phe Asn Gly Glu Leu Arg Arg Gly Gln
20 25 30
<210> 45
<211> 32
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 11的片段
<400> 45
His Ile Ala Gly Lys Ser Ser Ile Phe Arg Ala Leu Pro Asn Asp Val
1 5 10 15
Leu Ala Asn Ala Tyr Arg Ile Ser Arg Glu Glu Ala Gln Arg Leu Lys
20 25 30
<210> 46
<211> 29
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 11的片段
<400> 46
Val Pro Val Val Ala Ile Tyr Val Thr Asp Leu Asn Asn Gly Ala Asn
1 5 10 15
Gln Leu Asp Pro Arg Gln Arg Asp Phe Leu Leu Ala Gly
20 25
<210> 47
<211> 52
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 12的片段
<400> 47
Thr Phe Cys Thr Met Arg Val Arg Gln Asn Ile Asp Asn Pro Asn Arg
1 5 10 15
Ala Asp Thr Tyr Asn Pro Arg Ala Gly Arg Val Thr Asn Leu Asn Ser
20 25 30
Gln Asn Phe Pro Ile Leu Asn Leu Val Gln Met Ser Ala Val Lys Val
35 40 45
Asn Leu Tyr Gln
50
<210> 48
<211> 73
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 12的片段
<400> 48
Tyr Ile Ala Phe Lys Thr Asn Pro Asn Ser Met Val Ser His Ile Ala
1 5 10 15
Gly Lys Ser Ser Ile Phe Arg Ala Leu Pro Thr Asp Val Leu Ala Asn
20 25 30
Ala Tyr Arg Ile Ser Arg Glu Glu Ala Gln Arg Leu Lys His Asn Arg
35 40 45
Gly Asp Glu Phe Gly Ala Phe Thr Pro Leu Gln Tyr Lys Ser Tyr Gln
50 55 60
Asp Val Tyr Asn Val Ala Glu Ser Ser
65 70
<210> 49
<211> 36
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 12的片段
<400> 49
Ser Gln Ser His Lys Phe Lys Asp Glu His Gln Lys Ile His Arg Phe
1 5 10 15
Arg Gln Gly Asp Val Ile Ala Leu Pro Ala Gly Val Ala His Trp Cys
20 25 30
Tyr Asn Asp Gly
35
<210> 50
<211> 29
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 12的片段
<400> 50
Thr Gln Gly Arg Ala Gln Val Gln Val Val Asn Asn Asn Gly Lys Thr
1 5 10 15
Val Phe Asn Gly Glu Leu Arg Arg Gly Gln Leu Leu Ile
20 25
<210> 51
<211> 24
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 12的片段
<400> 51
Asn Gly Ala Ser Leu Val Tyr Ile Ile Gln Gly Arg Gly Ile Thr Gly
1 5 10 15
Pro Thr Phe Pro Gly Cys Pro Glu
20
<210> 52
<211> 21
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 12的片段
<400> 52
Cys Arg Phe Asp Arg Leu Gln Ala Phe Glu Pro Ile Arg Ser Val Arg
1 5 10 15
Ser Gln Ala Gly Thr
20
<210> 53
<211> 40
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 12的片段
<400> 53
Gln Asn Asp Gln Arg Gly Glu Ile Val Arg Val Glu Arg Gly Leu Ser
1 5 10 15
Leu Leu Gln Pro Tyr Ala Ser Leu Gln Glu Gln Glu Gln Gly Gln Met
20 25 30
Gln Ser Arg Glu His Tyr Gln Glu
35 40
<210> 54
<211> 35
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 12的片段
<400> 54
Pro Arg Gln Arg Asp Phe Leu Leu Ala Gly Asn Lys Arg Asn Pro Gln
1 5 10 15
Ala Tyr Arg Arg Glu Val Glu Glu Trp Ser Gln Asn Ile Phe Ser Gly
20 25 30
Phe Ser Thr
35
<210> 55
<211> 23
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 13的片段
<400> 55
Gly Gly Ile Tyr Arg Glu Leu Gly Ala Pro Asp Val Gly His Pro Met
1 5 10 15
Ser Glu Val Phe Arg Gly Cys
20
<210> 56
<211> 26
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 14的片段
<400> 56
His Ser Leu Val Tyr Ile Val Gln Gly His Ala Arg Val Gln Val Val
1 5 10 15
Ser Asn Leu Gly Lys Thr Val Phe Asn Gly
20 25
<210> 57
<211> 23
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 14的片段
<400> 57
Ala Arg Ser Leu Lys Asn Asn Arg Gly Glu Glu Leu Gly Ala Phe Thr
1 5 10 15
Pro Arg Tyr Gln Gln Gln Thr
20
<210> 58
<211> 23
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 14的片段
<400> 58
Leu Asn Ser Gln Lys Phe Pro Ile Leu Asn Leu Val Gln Leu Ser Ala
1 5 10 15
Thr Arg Val Asn Leu Tyr Gln
20
<210> 59
<211> 84
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 14的片段
<400> 59
Gln Met Tyr Gly Arg Ser Ile Glu Gln His Ser Gly Gln Asn Ile Phe
1 5 10 15
Ser Gly Phe Asn Asn Glu Leu Leu Ser Glu Ala Leu Gly Val Asn Ala
20 25 30
Leu Val Ala Lys Arg Leu Gln Gly Gln Asn Asp Gln Arg Gly Glu Ile
35 40 45
Ile Arg Val Lys Asn Gly Leu Lys Leu Leu Arg Pro Ala Phe Ala Gln
50 55 60
Gln Gln Glu Gln Ala Gln Gln Gln Glu Gln Ala Gln Ala Gln Tyr Gln
65 70 75 80
Val Gln Tyr Ser
<210> 60
<211> 24
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 14的片段
<400> 60
Ala Gln Leu Phe Gly Pro Asn Val Asn Pro Trp His Asn Pro Arg Gln
1 5 10 15
Gly Gly Phe Arg Glu Cys Arg Phe
20
<210> 61
<211> 23
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 14的片段
<400> 61
Gly Val Ala His Trp Phe Tyr Asn Glu Gly Asp Ala Pro Val Val Ala
1 5 10 15
Leu Tyr Val Phe Asp Leu Asn
20
<210> 62
<211> 40
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 14的片段
<400> 62
Tyr Ile Ser Phe Lys Thr Asn Ala Asn Ser Met Val Ser His Leu Ala
1 5 10 15
Gly Lys Asn Ser Ile Phe Arg Ala Met Pro Val Asp Val Ile Ala Asn
20 25 30
Ala Tyr Arg Ile Ser Arg Glu Gln
35 40
<210> 63
<211> 38
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 15的片段
<400> 63
Lys Gly Pro Ala Lys Asn Trp Glu Asn Val Leu Leu Gly Leu Gly Val
1 5 10 15
Ala Gly Ser Ala Pro Gly Ile Glu Gly Asp Glu Ile Ala Pro Leu Ala
20 25 30
Lys Glu Asn Val Ala Ala
35
<210> 64
<211> 31
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 15的片段
<400> 64
Arg Ala Val Val Lys Phe Asn Ala Pro Leu Ala His Leu Ile Met Ala
1 5 10 15
Gly Ala Asp Val Leu Ala Val Pro Ser Arg Phe Glu Pro Cys Gly
20 25 30
<210> 65
<211> 22
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 15的片段
<400> 65
Lys Arg Ala Ile Lys Val Val Gly Thr Pro Ala Tyr Glu Glu Met Val
1 5 10 15
Arg Asn Cys Met Asn Gln
20
<210> 66
<211> 55
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 15的片段
<400> 66
Ala Pro Trp Ser Lys Thr Gly Gly Leu Gly Asp Val Leu Gly Gly Leu
1 5 10 15
Pro Pro Ala Met Ala Ala Asn Gly His Arg Val Met Val Ile Ser Pro
20 25 30
Arg Tyr Asp Gln Tyr Lys Asp Ala Trp Asp Thr Ser Val Val Ala Glu
35 40 45
Ile Lys Val Ala Asp Arg Tyr
50 55
<210> 67
<211> 109
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 15的片段
<400> 67
Ile Asn Trp Met Lys Ala Gly Ile Leu Glu Ala Asp Arg Val Leu Thr
1 5 10 15
Val Ser Pro Tyr Tyr Ala Glu Glu Leu Ile Ser Gly Ile Ala Arg Gly
20 25 30
Cys Glu Leu Asp Asn Ile Met Arg Leu Thr Gly Ile Thr Gly Ile Val
35 40 45
Asn Gly Met Asp Val Ser Glu Trp Asp Pro Ser Lys Asp Lys Tyr Ile
50 55 60
Thr Ala Lys Tyr Asp Ala Thr Thr Ala Ile Glu Ala Lys Ala Leu Asn
65 70 75 80
Lys Glu Ala Leu Gln Ala Glu Ala Gly Leu Pro Val Asp Arg Lys Ile
85 90 95
Pro Leu Ile Ala Phe Ile Gly Arg Leu Glu Glu Gln Lys
100 105
<210> 68
<211> 45
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 15的片段
<400> 68
Arg Gly Val Asp Arg Val Phe Ile Asp His Pro Ser Phe Leu Glu Lys
1 5 10 15
Val Trp Gly Lys Thr Gly Glu Lys Ile Tyr Gly Pro Asp Thr Gly Val
20 25 30
Asp Tyr Lys Asp Asn Gln Met Arg Phe Ser Leu Leu Cys
35 40 45
<210> 69
<211> 21
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 15的片段
<400> 69
Leu Glu Ala Pro Arg Ile Leu Asn Leu Asn Asn Asn Pro Tyr Phe Lys
1 5 10 15
Gly Thr Tyr Gly Glu
20
<210> 70
<211> 26
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 16的片段
<400> 70
Tyr Ile Gln Val Glu Ala Pro Thr Gly Thr Phe Ile Ala Ser Gly Val
1 5 10 15
Val Val Gly Lys Asp Thr Leu Leu Thr Asn
20 25
<210> 71
<211> 12
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 1的片段
<400> 71
Ser Arg Gly Pro Ile Tyr Ser Asn Glu Phe Gly Lys
1 5 10
<210> 72
<211> 7
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 1的片段
<400> 72
Asn Ser Phe Asn Leu Glu Arg
1 5
<210> 73
<211> 10
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 1的片段
<400> 73
Val Leu Asp Leu Ala Ile Pro Val Asn Arg
1 5 10
<210> 74
<211> 7
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 1的片段
<400> 74
Asp Asp Asn Glu Glu Leu Arg
1 5
<210> 75
<211> 18
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 1的片段
<400> 75
Leu Ser Ser Gly Asp Val Phe Val Ile Pro Ala Gly His Pro Val Ala
1 5 10 15
Val Lys
<210> 76
<211> 15
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 1的片段
<400> 76
Glu Asp Asp Glu Glu Glu Glu Gln Gly Glu Glu Glu Ile Asn Lys
1 5 10 15
<210> 77
<211> 29
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 1的片段
<400> 77
Asn Ile Leu Glu Ala Ser Phe Asn Thr Asp Tyr Glu Glu Ile Glu Lys
1 5 10 15
Val Leu Leu Glu Glu His Glu Lys Glu Thr Gln His Arg
20 25
<210> 78
<211> 24
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 1的片段
<400> 78
Asn Ile Leu Glu Ala Ser Phe Asn Thr Asp Tyr Glu Glu Ile Glu Lys
1 5 10 15
Val Leu Leu Glu Glu His Glu Lys
20
<210> 79
<211> 16
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 1的片段
<400> 79
Asn Ile Leu Glu Ala Ser Phe Asn Thr Asp Tyr Glu Glu Ile Glu Lys
1 5 10 15
<210> 80
<211> 12
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 1的片段
<400> 80
Arg Gln Gln Ser Gln Glu Glu Asn Val Ile Val Lys
1 5 10
<210> 81
<211> 11
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 1的片段
<400> 81
Gln Gln Ser Gln Glu Glu Asn Val Ile Val Lys
1 5 10
<210> 82
<211> 11
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 1的片段
<400> 82
Leu Ser Arg Gly Gln Ile Glu Glu Leu Ser Lys
1 5 10
<210> 83
<211> 8
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 1的片段
<400> 83
Gly Gln Ile Glu Glu Leu Ser Lys
1 5
<210> 84
<211> 8
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 1的片段
<400> 84
Val Leu Leu Glu Glu His Glu Lys
1 5
<210> 85
<211> 24
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 1的片段
<400> 85
Ser Lys Pro His Thr Ile Phe Leu Pro Gln His Thr Asp Ala Asp Tyr
1 5 10 15
Ile Leu Val Val Leu Ser Gly Lys
20
<210> 86
<211> 22
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 1的片段
<400> 86
Pro His Thr Ile Phe Leu Pro Gln His Thr Asp Ala Asp Tyr Ile Leu
1 5 10 15
Val Val Leu Ser Gly Lys
20
<210> 87
<211> 16
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 1的片段
<400> 87
Ser Asn Lys Phe Gln Thr Leu Phe Glu Asn Glu Asn Gly His Ile Arg
1 5 10 15
<210> 88
<211> 11
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 1的片段
<400> 88
Ser Lys Ile Phe Glu Asn Leu Gln Asn Tyr Arg
1 5 10
<210> 89
<211> 9
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 1的片段
<400> 89
Ile Phe Glu Asn Leu Gln Asn Tyr Arg
1 5
<210> 90
<211> 18
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 1的片段
<400> 90
Ile Leu Glu Asn Gln Lys Gln Ser His Phe Ala Asp Ala Gln Pro Gln
1 5 10 15
Gln Arg
<210> 91
<211> 24
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 1的片段
<400> 91
Pro Gly Gln Leu Gln Ser Phe Leu Leu Ser Gly Asn Gln Asn Gln Gln
1 5 10 15
Asn Tyr Leu Ser Gly Phe Ser Lys
20
<210> 92
<211> 25
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 2的片段
<400> 92
Phe Phe Glu Leu Thr Pro Glu Lys Asn Gln Gln Leu Gln Asp Leu Asp
1 5 10 15
Leu Phe Val Asn Ser Val Asp Leu Lys
20 25
<210> 93
<211> 7
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 2的片段
<400> 93
Gln Leu Glu Glu Leu Ser Lys
1 5
<210> 94
<211> 11
<212> PRT
<213> 人工序列
<220>
<223> SE QID 3的片段
<400> 94
Gln Glu Glu Asp Glu Asp Glu Asp Glu Glu Arg
1 5 10
<210> 95
<211> 23
<212> PRT
<213> 人工序列
<220>
<223> SEQ 3的片段
<400> 95
Tyr Gln His Gln Gln Gly Gly Lys Gln Glu Gln Glu Asn Glu Gly Asn
1 5 10 15
Asn Ile Phe Ser Gly Phe Lys
20
<210> 96
<211> 24
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 4的片段
<400> 96
Gly Asp Thr Ile Lys Leu Pro Ala Gly Thr Thr Ser Tyr Leu Val Asn
1 5 10 15
Gln Asp Asp Glu Glu Asp Leu Arg
20
<210> 97
<211> 12
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 4的片段
<400> 97
Arg Gln Gln Gly Glu Glu Thr Asp Ala Ile Val Lys
1 5 10
<210> 98
<211> 11
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 4的片段
<400> 98
Val Leu Leu Glu Glu Gln Glu Lys Asp Arg Lys
1 5 10
<210> 99
<211> 10
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 4的片段
<400> 99
Asn Ile Leu Glu Ala Ser Tyr Asn Thr Arg
1 5 10
<210> 100
<211> 8
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 4的片段
<400> 100
Phe Glu Ala Phe Asp Leu Ala Lys
1 5
<210> 101
<211> 8
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 4的片段
<400> 101
Glu Gln Ile Glu Glu Leu Lys Lys
1 5
<210> 102
<211> 7
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 4的片段
<400> 102
Glu Gln Ile Glu Glu Leu Lys
1 5
<210> 103
<211> 7
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 4的片段
<400> 103
Asn Lys Asn Gln Tyr Leu Arg
1 5
<210> 104
<211> 37
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 4的片段
<400> 104
Leu Ser Pro Gly Asp Val Val Ile Ile Pro Ala Gly His Pro Val Ala
1 5 10 15
Ile Thr Ala Ser Ser Asn Leu Asn Leu Leu Gly Phe Gly Ile Asn Ala
20 25 30
Glu Asn Asn Glu Arg
35
<210> 105
<211> 14
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 4的片段
<400> 105
Pro Ser Tyr Glu Lys Gln Glu Asp Glu Glu Glu Lys Gln Lys
1 5 10
<210> 106
<211> 9
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 4的片段
<400> 106
Glu Glu Asp Glu Glu Glu Gly Gln Arg
1 5
<210> 107
<211> 20
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 5的片段
<400> 107
Thr Leu Phe Leu Pro Gln Tyr Thr Asp Ala Asp Phe Ile Leu Val Val
1 5 10 15
Leu Ser Gly Lys
20
<210> 108
<211> 24
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 6的片段
<400> 108
Gly Tyr Val Gly Leu Thr Phe Pro Gly Cys Pro Ala Thr His Gln Gln
1 5 10 15
Gln Phe Gln Leu Phe Glu Gln Arg
20
<210> 109
<211> 14
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 7的片段
<400> 109
Arg Gly Pro Gln Gln Tyr Ala Glu Trp Gln Ile Asn Glu Lys
1 5 10
<210> 110
<211> 21
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 8的片段
<400> 110
Leu Val Asp Leu Val Ile Pro Val Asn Gly Pro Gly Lys Phe Glu Ala
1 5 10 15
Phe Asp Leu Ala Lys
20
<210> 111
<211> 18
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 9的片段
<400> 111
Lys Asn Pro Gln Leu Gln Asp Leu Asp Ile Phe Val Asn Tyr Val Glu
1 5 10 15
Ile Lys
<210> 112
<211> 10
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 10的片段
<400> 112
Asp Glu His Gln Lys Ile His Gln Phe Arg
1 5 10
<210> 113
<211> 7
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 10的片段
<400> 113
Phe Arg Asp Glu His Gln Lys
1 5
<210> 114
<211> 13
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 10的片段
<400> 114
Phe Pro Ile Leu Asn Leu Ile Gln Met Ser Ala Thr Arg
1 5 10
<210> 115
<211> 13
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 10的片段
<400> 115
Thr Asn Ala Asn Ala Phe Val Ser His Leu Ala Gly Lys
1 5 10
<210> 116
<211> 12
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 10的片段
<400> 116
Ala Leu Pro Val Asp Val Val Ala Asn Ala Tyr Arg
1 5 10
<210> 117
<211> 20
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 10的片段
<400> 117
Tyr Val Tyr Asp Val Asn Asn Asn Ala Asn Gln Leu Glu Pro Arg Gln
1 5 10 15
Lys Glu Phe Leu
20
<210> 118
<211> 21
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 10的片段
<400> 118
Val Tyr Val Tyr Asp Val Asn Asn Asn Ala Asn Gln Leu Glu Pro Arg
1 5 10 15
Gln Lys Glu Phe Leu
20
<210> 119
<211> 7
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 10的片段
<400> 119
Ala Asp Ser Tyr Asn Pro Arg
1 5
<210> 120
<211> 16
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 10的片段
<400> 120
Lys Pro Thr Leu Thr Gln Gln Gln Glu Gln Ala Gln Ala Gln Asp Gln
1 5 10 15
<210> 121
<211> 13
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 10的片段
<400> 121
Gln Ala Gln Ala Gln Asp Gln Tyr Gln Gln Val Gln Tyr
1 5 10
<210> 122
<211> 11
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 10的片段
<400> 122
Gln Ala Gln Asp Gln Tyr Gln Gln Val Gln Tyr
1 5 10
<210> 123
<211> 8
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 10的片段
<400> 123
Leu Gln Ala Phe Glu Pro Leu Arg
1 5
<210> 124
<211> 11
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 10的片段
<400> 124
Ser Arg Val Gln Val Val Ser Asn Phe Gly Lys
1 5 10
<210> 125
<211> 10
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 10的片段
<400> 125
Trp Asn Val Asn Ala His Ser Leu Val Tyr
1 5 10
<210> 126
<211> 9
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 10的片段
<400> 126
Asn Val Asn Ala His Ser Leu Val Tyr
1 5
<210> 127
<211> 15
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 10的片段
<400> 127
Ile Gln Gly Arg Ser Arg Val Gln Val Val Ser Asn Phe Gly Lys
1 5 10 15
<210> 128
<211> 14
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 10的片段
<400> 128
Gly Lys Thr Val Phe Asp Gly Val Leu Arg Pro Gly Gln Leu
1 5 10
<210> 129
<211> 15
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 10的片段
<400> 129
Phe Gly Lys Thr Val Phe Asp Gly Val Leu Arg Pro Gly Gln Leu
1 5 10 15
<210> 130
<211> 19
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 10的片段
<400> 130
Phe Gln Gln Gln Tyr Tyr Pro Gly Leu Ser Asn Glu Ser Glu Ser Glu
1 5 10 15
Thr Ser Glu
<210> 131
<211> 9
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 10的片段
<400> 131
Gln Gln Tyr Tyr Pro Gly Leu Ser Asn
1 5
<210> 132
<211> 10
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 10的片段
<400> 132
Gln Gln Gln Tyr Tyr Pro Gly Leu Ser Asn
1 5 10
<210> 133
<211> 21
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 11的片段
<400> 133
Val Thr Asn Leu Asn Thr Gln Asn Phe Pro Ile Leu Ser Leu Val Gln
1 5 10 15
Met Ser Ala Val Lys
20
<210> 134
<211> 19
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 11的片段
<400> 134
Ile Thr Gln Gly Arg Ala Arg Val Gln Val Val Asn Asn Asn Gly Lys
1 5 10 15
Thr Val Phe
<210> 135
<211> 22
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 11的片段
<400> 135
Ile Thr Gln Gly Arg Ala Arg Val Gln Val Val Asn Asn Asn Gly Lys
1 5 10 15
Thr Val Phe Asn Gly Glu
20
<210> 136
<211> 21
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 11的片段
<400> 136
Ile Thr Gln Gly Arg Ala Arg Val Gln Val Val Asn Asn Asn Gly Lys
1 5 10 15
Thr Val Phe Asn Gly
20
<210> 137
<211> 13
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 11的片段
<400> 137
Arg Val Gln Val Val Asn Asn Asn Gly Lys Thr Val Phe
1 5 10
<210> 138
<211> 18
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 11的片段
<400> 138
Arg Ala Leu Pro Asn Asp Val Leu Ala Asn Ala Tyr Arg Ile Ser Arg
1 5 10 15
Glu Glu
<210> 139
<211> 16
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 11的片段
<400> 139
Ser Ile Phe Arg Ala Leu Pro Asn Asp Val Leu Ala Asn Ala Tyr Arg
1 5 10 15
<210> 140
<211> 15
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 11的片段
<400> 140
Ser Ile Phe Arg Ala Leu Pro Asn Asp Val Leu Ala Asn Ala Tyr
1 5 10 15
<210> 141
<211> 13
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 11的片段
<400> 141
Ser Ile Phe Arg Ala Leu Pro Asn Asp Val Leu Ala Asn
1 5 10
<210> 142
<211> 17
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 11的片段
<400> 142
Ser Ser Ile Phe Arg Ala Leu Pro Asn Asp Val Leu Ala Asn Ala Tyr
1 5 10 15
Arg
<210> 143
<211> 21
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 11的片段
<400> 143
Ser Ile Phe Arg Ala Leu Pro Asn Asp Val Leu Ala Asn Ala Tyr Arg
1 5 10 15
Ile Ser Arg Glu Glu
20
<210> 144
<211> 9
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 11的片段
<400> 144
Ser Ile Phe Arg Ala Leu Pro Asn Asp
1 5
<210> 145
<211> 19
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 11的片段
<400> 145
Ile Tyr Val Thr Asp Leu Asn Asn Gly Ala Asn Gln Leu Asp Pro Arg
1 5 10 15
Gln Arg Asp
<210> 146
<211> 21
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 12的片段
<400> 146
Val Thr Asn Leu Asn Ser Gln Asn Phe Pro Ile Leu Asn Leu Val Gln
1 5 10 15
Met Ser Ala Val Lys
20
<210> 147
<211> 8
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 12的片段
<400> 147
Gln Asn Ile Asp Asn Pro Asn Arg
1 5
<210> 148
<211> 7
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 12的片段
<400> 148
Ala Asp Thr Tyr Asn Pro Arg
1 5
<210> 149
<211> 21
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 12的片段
<400> 149
Asn Ile Asp Asn Pro Asn Arg Ala Asp Thr Tyr Asn Pro Arg Ala Gly
1 5 10 15
Arg Val Thr Asn Leu
20
<210> 150
<211> 25
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 12的片段
<400> 150
Arg Val Arg Gln Asn Ile Asp Asn Pro Asn Arg Ala Asp Thr Tyr Asn
1 5 10 15
Pro Arg Ala Gly Arg Val Thr Asn Leu
20 25
<210> 151
<211> 18
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 12的片段
<400> 151
Thr Asn Pro Asn Ser Met Val Ser His Ile Ala Gly Lys Ser Ser Ile
1 5 10 15
Phe Arg
<210> 152
<211> 16
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 12的片段
<400> 152
His Asn Arg Gly Asp Glu Phe Gly Ala Phe Thr Pro Leu Gln Tyr Lys
1 5 10 15
<210> 153
<211> 12
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 12的片段
<400> 153
Ser Tyr Gln Asp Val Tyr Asn Val Ala Glu Ser Ser
1 5 10
<210> 154
<211> 8
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 12的片段
<400> 154
Ile Ser Arg Glu Glu Ala Gln Arg
1 5
<210> 155
<211> 21
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 12的片段
<400> 155
Ser Ile Phe Arg Ala Leu Pro Thr Asp Val Leu Ala Asn Ala Tyr Arg
1 5 10 15
Ile Ser Arg Glu Glu
20
<210> 156
<211> 19
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 12的片段
<400> 156
Tyr Arg Ile Ser Arg Glu Glu Ala Gln Arg Leu Lys His Asn Arg Gly
1 5 10 15
Asp Glu Phe
<210> 157
<211> 18
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 12的片段
<400> 157
Tyr Arg Ile Ser Arg Glu Glu Ala Gln Arg Leu Lys His Asn Arg Gly
1 5 10 15
Asp Glu
<210> 158
<211> 10
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 12的片段
<400> 158
Phe Lys Asp Glu His Gln Lys Ile His Arg
1 5 10
<210> 159
<211> 14
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 12的片段
<400> 159
Gln Gly Asp Val Ile Ala Leu Pro Ala Gly Val Ala His Trp
1 5 10
<210> 160
<211> 9
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 12的片段
<400> 160
Thr Val Phe Asn Gly Glu Leu Arg Arg
1 5
<210> 161
<211> 8
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 12的片段
<400> 161
Thr Val Phe Asn Gly Glu Leu Arg
1 5
<210> 162
<211> 13
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 12的片段
<400> 162
Gln Val Gln Val Val Asn Asn Asn Gly Lys Thr Val Phe
1 5 10
<210> 163
<211> 13
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 12的片段
<400> 163
Tyr Ile Ile Gln Gly Arg Gly Ile Thr Gly Pro Thr Phe
1 5 10
<210> 164
<211> 14
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 12的片段
<400> 164
Val Tyr Ile Ile Gln Gly Arg Gly Ile Thr Gly Pro Thr Phe
1 5 10
<210> 165
<211> 11
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 12的片段
<400> 165
Leu Gln Ala Phe Glu Pro Ile Arg Ser Val Arg
1 5 10
<210> 166
<211> 22
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 12的片段
<400> 166
Gly Leu Ser Leu Leu Gln Pro Tyr Ala Ser Leu Gln Glu Gln Glu Gln
1 5 10 15
Gly Gln Met Gln Ser Arg
20
<210> 167
<211> 8
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 12的片段
<400> 167
Gly Glu Ile Val Arg Val Glu Arg
1 5
<210> 168
<211> 13
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 12的片段
<400> 168
Arg Gly Leu Ser Leu Leu Gln Pro Tyr Ala Ser Leu Gln
1 5 10
<210> 169
<211> 15
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 12的片段
<400> 169
Arg Gly Leu Ser Leu Leu Gln Pro Tyr Ala Ser Leu Gln Glu Gln
1 5 10 15
<210> 170
<211> 16
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 12的片段
<400> 170
Arg Gly Leu Ser Leu Leu Gln Pro Tyr Ala Ser Leu Gln Glu Gln Glu
1 5 10 15
<210> 171
<211> 14
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 12的片段
<400> 171
Arg Gly Leu Ser Leu Leu Gln Pro Tyr Ala Ser Leu Gln Glu
1 5 10
<210> 172
<211> 7
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 12的片段
<400> 172
Arg Asn Pro Gln Ala Tyr Arg
1 5
<210> 173
<211> 13
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 12的片段
<400> 173
Phe Leu Leu Ala Gly Asn Lys Arg Asn Pro Gln Ala Tyr
1 5 10
<210> 174
<211> 10
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 12的片段
<400> 174
Glu Val Glu Glu Trp Ser Gln Asn Ile Phe
1 5 10
<210> 175
<211> 12
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 12的片段
<400> 175
Leu Ala Gly Asn Lys Arg Asn Pro Gln Ala Tyr Arg
1 5 10
<210> 176
<211> 12
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 12的片段
<400> 176
Phe Leu Leu Ala Gly Asn Lys Arg Asn Pro Gln Ala
1 5 10
<210> 177
<211> 13
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 13的片段
<400> 177
Glu Leu Gly Ala Pro Asp Val Gly His Pro Met Ser Glu
1 5 10
<210> 178
<211> 16
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 14的片段
<400> 178
Ile Val Gln Gly His Ala Arg Val Gln Val Val Ser Asn Leu Gly Lys
1 5 10 15
<210> 179
<211> 14
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 14的片段
<400> 179
Ile Val Gln Gly His Ala Arg Val Gln Val Val Ser Asn Leu
1 5 10
<210> 180
<211> 13
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 14的片段
<400> 180
Ile Val Gln Gly His Ala Arg Val Gln Val Val Ser Asn
1 5 10
<210> 181
<211> 13
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 14的片段
<400> 181
Asn Asn Arg Gly Glu Glu Leu Gly Ala Phe Thr Pro Arg
1 5 10
<210> 182
<211> 10
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 14的片段
<400> 182
Gly Glu Glu Leu Gly Ala Phe Thr Pro Arg
1 5 10
<210> 183
<211> 13
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 14的片段
<400> 183
Phe Pro Ile Leu Asn Leu Val Gln Leu Ser Ala Thr Arg
1 5 10
<210> 184
<211> 31
<212> PRT
<213> 人工序列
<220>
<223> SE QID 14的片段
<400> 184
Ser Ile Glu Gln His Ser Gly Gln Asn Ile Phe Ser Gly Phe Asn Asn
1 5 10 15
Glu Leu Leu Ser Glu Ala Leu Gly Val Asn Ala Leu Val Ala Lys
20 25 30
<210> 185
<211> 8
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 14的片段
<400> 185
Leu Gln Gly Gln Asn Asp Gln Arg
1 5
<210> 186
<211> 20
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 14的片段
<400> 186
Ser Gly Phe Asn Asn Glu Leu Leu Ser Glu Ala Leu Gly Val Asn Ala
1 5 10 15
Leu Val Ala Lys
20
<210> 187
<211> 20
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 14的片段
<400> 187
Pro Ala Phe Ala Gln Gln Gln Glu Gln Ala Gln Gln Gln Glu Gln Ala
1 5 10 15
Gln Ala Gln Tyr
20
<210> 188
<211> 15
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 14的片段
<400> 188
Val Ala Lys Arg Leu Gln Gly Gln Asn Asp Gln Arg Gly Glu Ile
1 5 10 15
<210> 189
<211> 17
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 14的片段
<400> 189
Ala Leu Val Ala Lys Arg Leu Gln Gly Gln Asn Asp Gln Arg Gly Glu
1 5 10 15
Ile
<210> 190
<211> 13
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 14的片段
<400> 190
Leu Gln Gly Gln Asn Asp Gln Arg Gly Glu Ile Ile Arg
1 5 10
<210> 191
<211> 14
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 14的片段
<400> 191
Pro Asn Val Asn Pro Trp His Asn Pro Arg Gln Gly Gly Phe
1 5 10
<210> 192
<211> 13
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 14的片段
<400> 192
Phe Tyr Asn Glu Gly Asp Ala Pro Val Val Ala Leu Tyr
1 5 10
<210> 193
<211> 10
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 14的片段
<400> 193
Phe Tyr Asn Glu Gly Asp Ala Pro Val Val
1 5 10
<210> 194
<211> 12
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 14的片段
<400> 194
Phe Tyr Asn Glu Gly Asp Ala Pro Val Val Ala Leu
1 5 10
<210> 195
<211> 11
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 14的片段
<400> 195
Phe Tyr Asn Glu Gly Asp Ala Pro Val Val Ala
1 5 10
<210> 196
<211> 13
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 14的片段
<400> 196
Thr Asn Ala Asn Ser Met Val Ser His Leu Ala Gly Lys
1 5 10
<210> 197
<211> 12
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 14的片段
<400> 197
Ala Met Pro Val Asp Val Ile Ala Asn Ala Tyr Arg
1 5 10
<210> 198
<211> 28
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 15的片段
<400> 198
Asn Trp Glu Asn Val Leu Leu Gly Leu Gly Val Ala Gly Ser Ala Pro
1 5 10 15
Gly Ile Glu Gly Asp Glu Ile Ala Pro Leu Ala Lys
20 25
<210> 199
<211> 19
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 15的片段
<400> 199
Asn Val Leu Leu Gly Leu Gly Val Ala Gly Ser Ala Pro Gly Ile Glu
1 5 10 15
Gly Asp Glu
<210> 200
<211> 28
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 15的片段
<400> 200
Asn Trp Glu Asn Val Leu Leu Gly Leu Gly Val Ala Gly Ser Ala Pro
1 5 10 15
Gly Ile Glu Gly Asp Glu Ile Ala Pro Leu Ala Lys
20 25
<210> 201
<211> 21
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 15的片段
<400> 201
Phe Asn Ala Pro Leu Ala His Leu Ile Met Ala Gly Ala Asp Val Leu
1 5 10 15
Ala Val Pro Ser Arg
20
<210> 202
<211> 10
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 15的片段
<400> 202
Phe Asn Ala Pro Leu Ala His Leu Ile Met
1 5 10
<210> 203
<211> 21
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 15的片段
<400> 203
Phe Asn Ala Pro Leu Ala His Leu Ile Met Ala Gly Ala Asp Val Leu
1 5 10 15
Ala Val Pro Ser Arg
20
<210> 204
<211> 12
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 15的片段
<400> 204
Val Val Gly Thr Pro Ala Tyr Glu Glu Met Val Arg
1 5 10
<210> 205
<211> 21
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 15的片段
<400> 205
Thr Gly Gly Leu Gly Asp Val Leu Gly Gly Leu Pro Pro Ala Met Ala
1 5 10 15
Ala Asn Gly His Arg
20
<210> 206
<211> 17
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 15的片段
<400> 206
Tyr Asp Gln Tyr Lys Asp Ala Trp Asp Thr Ser Val Val Ala Glu Ile
1 5 10 15
Lys
<210> 207
<211> 12
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 15的片段
<400> 207
Asp Ala Trp Asp Thr Ser Val Val Ala Glu Ile Lys
1 5 10
<210> 208
<211> 7
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 15的片段
<400> 208
Val Met Val Ile Ser Pro Arg
1 5
<210> 209
<211> 22
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 15的片段
<400> 209
Leu Thr Gly Ile Thr Gly Ile Val Asn Gly Met Asp Val Ser Glu Trp
1 5 10 15
Asp Pro Ser Lys Asp Lys
20
<210> 210
<211> 18
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 15的片段
<400> 210
Val Leu Thr Val Ser Pro Tyr Tyr Ala Glu Glu Leu Ile Ser Gly Ile
1 5 10 15
Ala Arg
<210> 211
<211> 14
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 15的片段
<400> 211
Glu Ala Leu Gln Ala Glu Ala Gly Leu Pro Val Asp Arg Lys
1 5 10
<210> 212
<211> 10
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 15的片段
<400> 212
Tyr Asp Ala Thr Thr Ala Ile Glu Ala Lys
1 5 10
<210> 213
<211> 9
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 15的片段
<400> 213
Ile Pro Leu Ile Ala Phe Ile Gly Arg
1 5
<210> 214
<211> 8
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 15的片段
<400> 214
Ala Gly Ile Leu Glu Ala Asp Arg
1 5
<210> 215
<211> 9
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 15的片段
<400> 215
Ile Pro Leu Ile Ala Phe Ile Gly Arg
1 5
<210> 216
<211> 11
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 15的片段
<400> 216
Val Phe Ile Asp His Pro Ser Phe Leu Glu Lys
1 5 10
<210> 217
<211> 13
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 15的片段
<400> 217
Gly Pro Asp Thr Gly Val Asp Tyr Lys Asp Asn Gln Met
1 5 10
<210> 218
<211> 16
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 15的片段
<400> 218
Ile Tyr Gly Pro Asp Thr Gly Val Asp Tyr Lys Asp Asn Gln Met Arg
1 5 10 15
<210> 219
<211> 11
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 15的片段
<400> 219
Ile Tyr Gly Pro Asp Thr Gly Val Asp Tyr Lys
1 5 10
<210> 220
<211> 11
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 15的片段
<400> 220
Ile Leu Asn Leu Asn Asn Asn Pro Tyr Phe Lys
1 5 10
<210> 221
<211> 16
<212> PRT
<213> 人工序列
<220>
<223> SEQ ID 16的片段
<400> 221
Ala Pro Thr Gly Thr Phe Ile Ala Ser Gly Val Val Val Gly Lys Asp
1 5 10 15
<210> 222
<211> 463
<212> PRT
<213> 蚕豆
<400> 222
Met Ala Ala Thr Thr Leu Lys Asp Ser Phe Pro Leu Leu Thr Leu Leu
1 5 10 15
Gly Ile Ala Phe Leu Ala Ser Val Cys Leu Ser Ser Arg Ser Asp Gln
20 25 30
Asp Asn Pro Phe Val Phe Glu Ser Asn Arg Phe Gln Thr Leu Phe Glu
35 40 45
Asn Glu Asn Gly His Ile Arg Leu Leu Gln Lys Phe Asp Gln His Ser
50 55 60
Lys Leu Leu Glu Asn Leu Gln Asn Tyr Arg Leu Leu Glu Tyr Lys Ser
65 70 75 80
Lys Pro His Thr Ile Phe Leu Pro Gln Gln Thr Asp Ala Asp Phe Ile
85 90 95
Leu Val Val Leu Ser Gly Lys Ala Ile Leu Thr Val Leu Leu Pro Asn
100 105 110
Asp Arg Asn Ser Phe Ser Leu Glu Arg Gly Asp Thr Ile Lys Leu Pro
115 120 125
Ala Gly Thr Ile Gly Tyr Leu Val Asn Arg Asp Asp Glu Glu Asp Leu
130 135 140
Arg Val Leu Asp Leu Val Ile Pro Val Asn Arg Pro Gly Glu Pro Gln
145 150 155 160
Ser Phe Leu Leu Ser Gly Asn Gln Asn Gln Pro Ser Ile Leu Ser Gly
165 170 175
Phe Ser Lys Asn Ile Leu Glu Ala Ser Phe Asn Thr Asp Tyr Lys Glu
180 185 190
Ile Glu Lys Val Leu Leu Glu Glu His Gly Lys Glu Lys Tyr His Arg
195 200 205
Arg Gly Leu Lys Asp Arg Arg Gln Arg Gly Gln Glu Glu Asn Val Ile
210 215 220
Val Lys Ile Ser Arg Lys Gln Ile Glu Glu Leu Asn Lys Asn Ala Lys
225 230 235 240
Ser Ser Ser Lys Lys Ser Thr Ser Ser Glu Ser Glu Pro Phe Asn Leu
245 250 255
Arg Ser Arg Glu Pro Ile Tyr Ser Asn Lys Phe Gly Lys Phe Phe Glu
260 265 270
Ile Thr Pro Lys Arg Asn Pro Gln Leu Gln Asp Leu Asn Ile Phe Val
275 280 285
Asn Tyr Val Glu Ile Asn Glu Gly Ser Leu Leu Leu Pro His Tyr Asn
290 295 300
Ser Arg Ala Ile Val Ile Val Thr Val Asn Glu Gly Lys Gly Asp Phe
305 310 315 320
Glu Leu Val Gly Gln Arg Asn Glu Asn Gln Gln Gly Leu Arg Glu Glu
325 330 335
Tyr Asp Glu Glu Lys Glu Gln Gly Glu Glu Glu Ile Arg Lys Gln Val
340 345 350
Gln Asn Tyr Lys Ala Lys Leu Ser Pro Gly Asp Val Leu Val Ile Pro
355 360 365
Ala Gly Tyr Pro Val Ala Ile Lys Ala Ser Ser Asn Leu Asn Leu Val
370 375 380
Gly Phe Gly Ile Asn Ala Glu Asn Asn Gln Arg Tyr Phe Leu Ala Gly
385 390 395 400
Glu Glu Asp Asn Val Ile Ser Gln Ile His Lys Pro Val Lys Glu Leu
405 410 415
Ala Phe Pro Gly Ser Ala Gln Glu Val Asp Thr Leu Leu Glu Asn Gln
420 425 430
Lys Gln Ser His Phe Ala Asn Ala Gln Pro Arg Glu Arg Glu Arg Gly
435 440 445
Ser Gln Glu Ile Lys Asp His Leu Tyr Ser Ile Leu Gly Ser Phe
450 455 460
<210> 223
<211> 446
<212> PRT
<213> 鹰嘴豆
<400> 223
Met Ala Ile Lys Ala Arg Phe Pro Leu Leu Val Leu Leu Gly Ile Val
1 5 10 15
Phe Leu Ala Ser Val Cys Ala Lys Ser Asp Lys Glu Asn Pro Phe Phe
20 25 30
Phe Lys Ser Asn Asn Cys Gln Thr Leu Phe Glu Asn Glu Asn Gly His
35 40 45
Val Arg Leu Leu Gln Arg Phe Asp Lys Arg Ser Gln Leu Phe Glu Asn
50 55 60
Leu Gln Asn Tyr Arg Leu Met Glu Tyr Asn Ser Lys Pro His Thr Leu
65 70 75 80
Phe Leu Pro Gln His Asn Asp Ala Asp Phe Ile Leu Val Val Leu Arg
85 90 95
Gly Arg Ala Ile Leu Thr Val Leu Asn Pro Asn Asp Arg Asn Thr Phe
100 105 110
Lys Leu Glu Arg Gly Asp Thr Ile Lys Leu Pro Ala Gly Thr Ile Ala
115 120 125
Tyr Leu Ala Asn Arg Asp Asp Asn Glu Asp Leu Arg Val Leu Asp Leu
130 135 140
Ala Ile Pro Val Asn Arg Pro Gly Gln Phe Gln Ser Phe Ser Leu Ser
145 150 155 160
Gly Asn Glu Asn Gln Gln Ser Tyr Phe Gln Gly Phe Ser Lys Lys Ile
165 170 175
Leu Glu Ala Ser Phe Asn Ser Asp Tyr Glu Glu Ile Glu Arg Val Leu
180 185 190
Leu Glu Glu Gln Glu Gln Lys Pro Glu Gln Arg Arg Gly His Lys Gly
195 200 205
Arg Gln Gln Ser Gln Glu Thr Asp Val Ile Val Lys Ile Ser Arg Glu
210 215 220
Gln Ile Glu Glu Leu Ser Lys Asn Ala Lys Ser Asn Cys Lys Lys Ser
225 230 235 240
Val Ser Ser Glu Ser Glu Pro Phe Asn Leu Arg Ser Arg Ser Pro Ile
245 250 255
Tyr Ser Asn Arg Phe Gly Asn Phe Phe Glu Ile Thr Pro Glu Lys Asn
260 265 270
Pro Gln Leu Lys Asp Leu Asp Ile Phe Val Asn Ser Val Glu Ile Lys
275 280 285
Glu Gly Ser Leu Leu Leu Pro His Phe Asn Ser Arg Ala Thr Val Ile
290 295 300
Leu Val Val Asn Glu Gly Lys Gly Glu Val Glu Leu Val Gly Leu Arg
305 310 315 320
Asn Glu Asn Glu Gln Glu Asn Lys Lys Glu Asp Glu Glu Glu Glu Glu
325 330 335
Asp Arg Asn Val Gln Val Gln Arg Phe Gln Ser Lys Leu Ser Ser Gly
340 345 350
Asp Val Val Val Ile Pro Ala Ser His Pro Phe Ser Ile Asn Ala Ser
355 360 365
Ser Asp Leu Phe Leu Leu Gly Phe Gly Ile Asn Ala Gln Asn Asn Gln
370 375 380
Arg Asn Phe Leu Ala Gly Glu Glu Asp Asn Val Ile Ser Gln Ile Gln
385 390 395 400
Arg Pro Val Lys Glu Val Ala Phe Pro Gly Ser Ala Glu Glu Val Asp
405 410 415
Arg Leu Leu Lys Asn Gln Arg Gln Ser His Phe Ala Asn Ala Gln Pro
420 425 430
Gln Gln Lys Arg Lys Gly Ser Gln Arg Ile Arg Ser Pro Phe
435 440 445
<210> 224
<211> 418
<212> PRT
<213> 兵豆
<400> 224
Ser Arg Ser Asp Gln Glu Asn Pro Phe Ile Phe Lys Ser Asn Arg Phe
1 5 10 15
Gln Thr Ile Tyr Glu Asn Glu Asn Gly His Ile Arg Leu Leu Gln Arg
20 25 30
Phe Asp Lys Arg Ser Lys Ile Phe Glu Asn Leu Gln Asn Tyr Arg Leu
35 40 45
Leu Glu Tyr Lys Ser Lys Pro His Thr Ile Phe Leu Pro Gln Phe Thr
50 55 60
Asp Ala Asp Phe Ile Leu Val Val Leu Ser Gly Lys Ala Ile Leu Thr
65 70 75 80
Val Leu Asn Ser Asn Asp Arg Asn Ser Phe Asn Leu Glu Arg Gly Asp
85 90 95
Thr Ile Lys Leu Pro Ala Gly Thr Ile Ala Tyr Leu Ala Asn Arg Asp
100 105 110
Asp Asn Glu Asp Leu Arg Val Leu Asp Leu Ala Ile Pro Val Asn Arg
115 120 125
Pro Gly Gln Leu Gln Ser Phe Leu Leu Ser Gly Thr Gln Asn Gln Pro
130 135 140
Ser Phe Leu Ser Gly Phe Ser Lys Asn Ile Leu Glu Ala Ala Phe Asn
145 150 155 160
Thr Glu Tyr Glu Glu Ile Glu Lys Val Leu Leu Glu Glu Gln Glu Gln
165 170 175
Lys Ser Gln His Arg Arg Ser Leu Arg Asp Lys Arg Gln Glu Ile Thr
180 185 190
Asn Glu Asp Val Ile Val Lys Val Ser Arg Glu Gln Ile Glu Glu Leu
195 200 205
Ser Lys Asn Ala Lys Ser Ser Ser Lys Lys Ser Val Ser Ser Glu Ser
210 215 220
Glu Pro Phe Asn Leu Arg Ser Arg Asn Pro Ile Tyr Ser Asn Lys Phe
225 230 235 240
Gly Lys Phe Phe Glu Ile Thr Pro Glu Lys Asn Pro Gln Leu Gln Asp
245 250 255
Leu Asp Ile Phe Val Asn Ser Val Glu Ile Lys Glu Gly Ser Leu Leu
260 265 270
Leu Pro Asn Tyr Asn Ser Arg Ala Ile Val Ile Val Thr Val Asn Glu
275 280 285
Gly Lys Gly Asp Phe Glu Leu Val Gly Gln Arg Asn Glu Asn Gln Gln
290 295 300
Glu Gln Arg Glu Glu Asn Asp Glu Glu Glu Gly Gln Glu Glu Glu Thr
305 310 315 320
Thr Lys Gln Val Gln Arg Tyr Arg Ala Arg Leu Ser Pro Gly Asp Val
325 330 335
Leu Val Ile Pro Ala Gly His Pro Val Ala Ile Asn Ala Ser Ser Asp
340 345 350
Leu Asn Leu Ile Gly Phe Gly Ile Asn Ala Lys Asn Asn Gln Arg Asn
355 360 365
Phe Leu Ala Gly Glu Glu Asp Asn Val Ile Ser Gln Ile Gln Arg Pro
370 375 380
Val Lys Glu Leu Ala Phe Pro Gly Ser Ser Arg Glu Val Asp Arg Leu
385 390 395 400
Leu Thr Asn Gln Lys Gln Ser His Phe Ala Asn Ala Gln Pro Leu Gln
405 410 415
Ile Glu
<210> 225
<211> 415
<212> PRT
<213> 兵豆
<400> 225
Ser Arg Ser Asp Gln Glu Asn Pro Phe Ile Phe Lys Ser Asn Arg Phe
1 5 10 15
Gln Thr Ile Tyr Glu Asn Glu Asn Gly His Ile Arg Leu Leu Gln Lys
20 25 30
Phe Asp Lys Arg Ser Lys Ile Phe Glu Asn Leu Gln Asn Tyr Arg Leu
35 40 45
Leu Glu Tyr Lys Ser Lys Pro His Thr Leu Phe Leu Pro Gln Tyr Thr
50 55 60
Asp Ala Asp Phe Ile Leu Val Val Leu Ser Gly Lys Ala Val Leu Thr
65 70 75 80
Val Leu Asn Ser Asn Asp Arg Asn Ser Phe Asn Leu Glu Arg Gly Asp
85 90 95
Thr Ile Lys Leu Pro Ala Gly Thr Ile Ala Tyr Leu Ala Asn Arg Asp
100 105 110
Asp Asn Glu Asp Leu Arg Val Leu Asp Leu Ala Ile Pro Val Asn Asn
115 120 125
Pro Gly Gln Leu Glu Ser Phe Leu Leu Ser Gly Thr Gln Asn Gln Pro
130 135 140
Ser Phe Leu Ser Gly Phe Asn Lys Ser Ile Leu Glu Ala Ala Phe Asn
145 150 155 160
Thr Asp Tyr Glu Glu Ile Glu Lys Val Leu Leu Glu Asp Gln Glu Gln
165 170 175
Glu Pro Gln His Arg Arg Ser Leu Arg Asp Arg Arg Gln Glu Ile Asn
180 185 190
Lys Glu Asn Val Ile Val Lys Val Ser Arg Glu Gln Ile Lys Glu Leu
195 200 205
Ser Lys Asn Ala Lys Ser Ser Ser Lys Lys Ser Val Ser Ser Glu Ser
210 215 220
Glu Pro Phe Asn Leu Arg Ser Arg Asn Pro Ile Tyr Ser Asn Lys Phe
225 230 235 240
Gly Lys Phe Phe Glu Ile Thr Pro Glu Lys Asn Pro Gln Leu Gln Asp
245 250 255
Leu Asp Ile Phe Val Asn Ser Val Glu Ile Lys Glu Gly Ser Leu Leu
260 265 270
Leu Pro Asn Tyr Asn Ser Arg Ala Ile Val Ile Val Thr Val Asn Glu
275 280 285
Gly Lys Gly Tyr Phe Glu Leu Val Gly Gln Arg Asn Glu Asn Gln Arg
290 295 300
Glu Glu Asn Asp Asp Glu Glu Glu Gln Glu Glu Glu Thr Ser Thr Gln
305 310 315 320
Val Gln Arg Tyr Arg Ala Lys Leu Ser Pro Gly Asp Val Phe Val Val
325 330 335
Pro Ala Gly His Pro Val Ala Ile Asn Ala Ser Ser Asp Leu Asn Leu
340 345 350
Ile Gly Phe Gly Ile Asn Ala Lys Asn Asn Gln Arg Asn Phe Leu Ala
355 360 365
Gly Glu Glu Asp Asn Val Ile Ser Gln Ile Gln Arg Pro Val Lys Glu
370 375 380
Leu Ala Phe Pro Gly Ser Ser Arg Glu Val Asp Arg Leu Leu Thr Asn
385 390 395 400
Gln Lys Gln Ser His Phe Ala Asn Ala Gln Pro Leu Gln Ile Glu
405 410 415
<210> 226
<211> 463
<212> PRT
<213> 法国野豌豆
<400> 226
Met Ala Ala Ile Thr Met Lys Val Ser Phe Pro Leu Leu Met Leu Leu
1 5 10 15
Gly Ile Ser Phe Leu Ala Ser Val Cys Val Ser Ser Arg Ser Asp Gln
20 25 30
Glu Asn Pro Phe Ile Phe Lys Ser Asn Lys Phe Gln Thr Leu Phe Glu
35 40 45
Asn Asp Asn Gly His Ile Arg Leu Leu Gln Lys Phe Asp Glu Arg Ser
50 55 60
Lys Ile Leu Glu Asn Leu Gln Asn Tyr Arg Leu Leu Glu Tyr Lys Ser
65 70 75 80
Lys Pro Arg Thr Ile Phe Leu Pro Gln Gln Thr Asn Ala Asp Phe Ile
85 90 95
Leu Val Val Leu Ser Gly Lys Ala Ile Leu Thr Val Leu Lys Pro Asp
100 105 110
Asp Arg Asn Ser Phe Asn Leu Glu Arg Gly Asp Thr Ile Lys Leu Pro
115 120 125
Ala Gly Thr Ile Ala Tyr Leu Val Asn Lys Asp Asp Asn Glu Asp Leu
130 135 140
Arg Val Leu Asp Leu Ala Ile Pro Val Asn Gly Pro Asp Gln Leu Gln
145 150 155 160
Ser Phe Leu Leu Ser Gly Ser Glu Asn Gln Gln Ser Ile Leu Ser Gly
165 170 175
Phe Ser Lys Ser Val Leu Glu Ala Ser Phe Asn Thr Gly Tyr Glu Glu
180 185 190
Ile Glu Lys Val Leu Leu Glu Glu Arg Glu Lys Glu Thr Gln His Arg
195 200 205
Arg Ser Leu Arg Asp Lys Arg Gln His Ser Gln Asp Glu Asp Val Ile
210 215 220
Val Lys Leu Ser Arg Gly Gln Ile Glu Glu Leu Ser Arg Asn Ala Lys
225 230 235 240
Ser Ser Ser Lys Lys Ser Val Ser Ser Glu Ser Glu Pro Phe Asn Leu
245 250 255
Arg Ser Arg Asn Pro Ile Tyr Ser Asn Lys Phe Gly Lys Phe Phe Glu
260 265 270
Ile Thr Pro Glu Lys Asn Pro Gln Leu Gln Asp Leu Asp Val Leu Val
275 280 285
Asn Ser Val Glu Ile Lys Glu Gly Ser Leu Leu Leu Pro His Tyr Asn
290 295 300
Ser Arg Ala Ile Val Ile Val Thr Val Asn Asp Gly Lys Gly Asp Phe
305 310 315 320
Glu Ile Val Gly Gln Arg Asn Glu Asn Arg Gln Gly Gln Arg Lys Glu
325 330 335
Asp Asp Glu Glu Glu Glu Gln Gly Asp Glu Asn Thr Asn Thr Gln Val
340 345 350
Gln Asn Tyr Lys Ala Lys Leu Ser Arg Gly Asp Val Phe Val Ile Pro
355 360 365
Ala Gly His Pro Val Ser Ile Lys Ala Ser Ser Asn Leu Asp Leu Leu
370 375 380
Gly Phe Gly Ile Asn Ala Lys Asn Asn Gln Arg Asn Phe Leu Ala Gly
385 390 395 400
Glu Glu Asp Asn Val Ile Ser Gln Ile Asp Arg Pro Val Lys Glu Leu
405 410 415
Ala Phe Pro Gly Ser Ala Gln Glu Val Asp Arg Leu Leu Glu Asn Gln
420 425 430
Lys Gln Ser His Phe Ala Asn Ala Gln Pro Gln Gln Arg Glu Arg Gly
435 440 445
Ser His Glu Thr Arg Asp His Leu Ser Ser Ile Leu Asp Ala Phe
450 455 460
<210> 227
<211> 396
<212> PRT
<213> 大豆
<400> 227
Gln Tyr Gly His Val Arg Val Leu Gln Arg Phe Asn Lys Arg Ser Gln
1 5 10 15
Gln Leu Gln Asn Leu Arg Asp Tyr Arg Ile Leu Glu Phe Asn Ser Lys
20 25 30
Pro Asn Thr Leu Leu Leu Pro His His Ala Asp Ala Asp Tyr Leu Ile
35 40 45
Val Ile Leu Asn Gly Thr Ala Ile Leu Thr Leu Val Asn Asn Asp Asp
50 55 60
Arg Asp Ser Tyr Asn Leu Gln Ser Gly Asp Ala Leu Arg Val Pro Ala
65 70 75 80
Gly Thr Thr Tyr Tyr Val Val Asn Pro Asp Asn Asp Glu Asn Leu Arg
85 90 95
Met Ile Thr Leu Ala Ile Pro Val Asn Lys Pro Gly Arg Phe Glu Ser
100 105 110
Phe Phe Leu Ser Ser Thr Gln Ala Gln Gln Ser Tyr Leu Gln Gly Phe
115 120 125
Ser Lys Asn Ile Leu Glu Ala Ser Tyr Asp Thr Lys Phe Glu Glu Ile
130 135 140
Asn Lys Val Leu Phe Gly Arg Glu Glu Gly Gln Gln Gln Gly Glu Glu
145 150 155 160
Arg Leu Gln Glu Ser Val Ile Val Glu Ile Ser Lys Lys Gln Ile Arg
165 170 175
Glu Leu Ser Lys His Ala Lys Ser Ser Ser Arg Lys Thr Ile Ser Ser
180 185 190
Glu Asp Lys Pro Phe Asn Leu Arg Ser Arg Asp Pro Ile Tyr Ser Asn
195 200 205
Lys Leu Gly Lys Leu Phe Glu Ile Thr Pro Glu Lys Asn Pro Gln Leu
210 215 220
Arg Asp Leu Asp Val Phe Leu Ser Val Val Asp Met Asn Glu Gly Ala
225 230 235 240
Leu Phe Leu Pro His Phe Asn Ser Lys Ala Ile Val Val Leu Val Ile
245 250 255
Asn Glu Gly Glu Ala Asn Ile Glu Leu Val Gly Ile Lys Glu Gln Gln
260 265 270
Gln Arg Gln Gln Gln Glu Glu Gln Pro Leu Glu Val Arg Lys Tyr Arg
275 280 285
Ala Glu Leu Ser Glu Gln Asp Ile Phe Val Ile Pro Ala Gly Tyr Pro
290 295 300
Val Val Val Asn Ala Thr Ser Asp Leu Asn Phe Phe Ala Phe Gly Ile
305 310 315 320
Asn Ala Glu Asn Asn Gln Arg Asn Phe Leu Ala Gly Ser Lys Asp Asn
325 330 335
Val Ile Ser Gln Ile Pro Ser Gln Val Gln Glu Leu Ala Phe Pro Gly
340 345 350
Ser Ala Lys Asp Ile Glu Asn Leu Ile Lys Ser Gln Ser Glu Ser Tyr
355 360 365
Phe Val Asp Ala Gln Pro Gln Gln Lys Glu Glu Gly Asn Lys Gly Arg
370 375 380
Lys Gly Pro Leu Ser Ser Ile Leu Arg Ala Phe Tyr
385 390 395
<210> 228
<211> 498
<212> PRT
<213> 箭筈豌豆
<400> 228
Met Ala Lys Leu Leu Ala Leu Ser Leu Ser Phe Cys Phe Leu Leu Phe
1 5 10 15
Ser Ser Cys Phe Ala Leu Arg Glu Gln Ser Gln Gln Asn Glu Cys Gln
20 25 30
Leu Glu Arg Ile Asn Ala Leu Glu Pro Asp Asn Arg Ile Glu Ser Glu
35 40 45
Gly Gly Leu Ile Glu Thr Trp Asn Pro Asn Asn Arg Gln Phe Arg Cys
50 55 60
Ala Arg Val Ala Leu Ser Arg Ala Thr Leu Gln Arg Asn Ala Leu Arg
65 70 75 80
Arg Pro Tyr Tyr Ser Asn Ala Pro Gln Glu Ile Tyr Ile Gln Gln Gly
85 90 95
Asn Gly Tyr Phe Gly Met Val Phe Pro Gly Cys Pro Glu Thr His Glu
100 105 110
Glu Pro Gln Gln Ser Glu Gln Gly Glu Gly Arg Arg Tyr Arg Asp Ser
115 120 125
His Gln Lys Val Asn Arg Phe Arg Glu Gly Asp Ile Ile Ala Val Pro
130 135 140
Thr Gly Ile Ala Phe Trp Met Tyr Asn Asp Gln Asp Thr Pro Val Ile
145 150 155 160
Ala Ile Ser Leu Thr Asp Thr Gly Ser Ser Asn Asn Gln Leu Asp Gln
165 170 175
Met Pro Arg Arg Phe Tyr Leu Ala Gly Asn Gln Glu Gln Glu Phe Leu
180 185 190
Arg Tyr Gln His Gln Gln Gly Gly Lys Gln Glu Gln Asp Asn Asp Gly
195 200 205
Asn Asn Ile Phe Ser Gly Phe Lys Arg Asp Phe Leu Glu Asp Ala Phe
210 215 220
Asn Val Asn Arg His Ile Val Asp Arg Leu Gln Gly Arg Asn Glu Asp
225 230 235 240
Glu Glu Lys Gly Ala Ile Val Lys Val Lys Gly Gly Leu Ser Ile Ile
245 250 255
Ala Pro Pro Glu Arg Gln Ala Arg His Glu Arg Gly Ser Arg Gln Glu
260 265 270
Glu Asp Glu Asp Glu Lys Glu Glu Arg Gln Pro Ser His His Lys Ser
275 280 285
Arg Arg Asp Glu Asp Glu Asp Asp Lys Glu Lys Arg His Ser Gln Lys
290 295 300
Gly Gln Ser Arg Arg Gln Gly Asp Asn Gly Leu Glu Glu Thr Val Cys
305 310 315 320
Thr Ala Lys Leu Arg Ala Asn Ile Gly Ser Ser Pro Ser Pro Asp Ile
325 330 335
Tyr Asn Pro Gln Ala Gly Arg Ile Lys Thr Val Thr Ser Leu Asp Leu
340 345 350
Pro Val Leu Arg Trp Leu Lys Leu Ser Ala Glu His Gly Ser Leu His
355 360 365
Lys Asn Ala Met Phe Val Pro His Tyr Asn Leu Asn Ala Asn Ser Val
370 375 380
Ile Tyr Ala Leu Lys Gly Arg Ala Arg Leu Gln Val Val Asn Cys Asn
385 390 395 400
Gly Asn Thr Val Phe Asp Gly Glu Leu Glu Ala Gly Arg Ala Leu Thr
405 410 415
Val Pro Gln Asn Tyr Ala Val Ala Ala Lys Ser Leu Ser Glu Arg Phe
420 425 430
Thr Tyr Val Ala Phe Lys Thr Asp Asp Arg Ala Ser Ile Ala Arg Leu
435 440 445
Ala Gly Thr Ser Ser Val Ile Asp Asp Leu Pro Leu Asp Val Val Ala
450 455 460
Ala Thr Phe Asn Met Gln Arg Asn Glu Ala Arg Gln Leu Lys Ser Asn
465 470 475 480
Asn Pro Phe Lys Phe Leu Val Pro Pro Arg Gln Ser Glu Met Arg Ala
485 490 495
Ser Ala
<210> 229
<211> 531
<212> PRT
<213> 蒺藜苜蓿
<400> 229
Met Ala Lys Leu Leu Ala Leu Ser Leu Ser Leu Cys Phe Leu Leu Phe
1 5 10 15
Ser Gly Cys Phe Ala Ile Arg Glu His Gln Pro His Gln Lys Gln Gln
20 25 30
Pro Gln Gln Asn Glu Cys Gln Leu Glu Gln Leu Asn Ala Leu Glu Pro
35 40 45
Asp Asn Arg Ile Glu Ser Glu Gly Gly Ile Ile Glu Thr Trp Asn Pro
50 55 60
Asn Asn Arg Gln Phe Arg Cys Ala Gly Val Ala Leu Ser Arg Cys Thr
65 70 75 80
Leu Gln Arg Asn Ser Leu Arg Arg Pro Phe Tyr Ser Asn Ala Pro Gln
85 90 95
Glu Ile Phe Ile Gln Gln Gly Ser Gly Tyr Phe Gly Met Val Phe Pro
100 105 110
Gly Cys Pro Glu Thr Phe Glu Glu Pro Gln Glu Ser Glu Gln Arg Glu
115 120 125
Ser Arg Arg Ile Arg Glu Ser Glu Gln Gly Glu Ser Arg Arg Ile Arg
130 135 140
Glu Ser Glu Gln Gly Glu Gly Arg Arg Phe Arg Asp Ser His Gln Lys
145 150 155 160
Val Asn Arg Phe Arg Glu Gly Asp Leu Ile Ala Val Pro Thr Gly Thr
165 170 175
Val Phe Trp Met Tyr Asn Asp Gln Asp Thr Pro Val Ile Ala Val Ser
180 185 190
Leu Ile Asp Thr Gly Ser Phe Gln Asn Gln Leu Asp Glu Met Pro Arg
195 200 205
Arg Phe Tyr Leu Ala Gly Asn Gln Glu Gln Glu Phe Leu Gln Tyr Gln
210 215 220
Gln Gln Gln Val Arg Gly Arg Gly Glu Gln Arg Arg Gly Arg Glu Gln
225 230 235 240
Gln Glu Asn Glu Gly Gly Asn Ile Phe Ser Gly Phe Lys Arg Asp Phe
245 250 255
Leu Glu Asp Ala Leu Asn Val Asn Arg His Ile Val Asp Arg Leu Gln
260 265 270
Gly Arg Asn Glu Asp Glu Glu Lys Gly Ala Ile Val Lys Val Arg Gly
275 280 285
Gly Leu Ser Phe Val Thr Pro Pro Glu Arg Gln Ser Arg His Gln Gly
290 295 300
Gly Ser Ile Ile Glu Glu Asp Glu Asp Glu Glu Asp Glu Trp Arg Arg
305 310 315 320
Pro His His Gln Lys Ser Arg Arg Gly Glu Glu Glu Glu Arg Pro Cys
325 330 335
Arg Arg Gly Gln Lys Cys Glu Arg Ser Asn Gly Leu Glu Glu Thr Ile
340 345 350
Cys Thr Ala Arg Leu Arg Gln Asn Ile Gly Ser Ser Ser Ser Pro Asp
355 360 365
Ile Tyr Asn Pro Glu Ala Gly Arg Ile Lys Thr Val Thr Ser Phe Asp
370 375 380
Leu Pro Ala Leu Arg Trp Leu Arg Leu Ser Ala Glu His Gly Thr Leu
385 390 395 400
His Arg Asn Ala Met Phe Val Pro His Tyr Asn Leu Asn Ala Asn Ser
405 410 415
Ala Ile Tyr Ala Leu Arg Gly Arg Ala Arg Leu Gln Val Val Asn Cys
420 425 430
Asn Gly Asn Thr Val Phe Asp Gly Glu Leu Glu Ala Gly Arg Val Leu
435 440 445
Ile Val Pro Gln Asn Phe Ala Val Ala Ala Lys Ser Met Ser Asp Arg
450 455 460
Phe Gln Tyr Val Ser Phe Lys Thr Asn Asp Asn Ala Ala Ile Ala Arg
465 470 475 480
Leu Ala Gly Thr Gln Ser Thr Leu Ser Gly Val Pro Met Asp Val Leu
485 490 495
Ala Ala Thr Tyr Asn Met Asp Arg Asn Glu Ala Arg Gln Leu Lys Asn
500 505 510
Asn Asn Leu Tyr Lys Phe Leu Val Pro Pro Arg Glu Ser Glu Arg Arg
515 520 525
Ala Ala Ala
530
<210> 230
<211> 476
<212> PRT
<213> 百脉根
<400> 230
Met Ala Tyr Lys Leu Phe Ala Leu Ser Leu Ser Phe Cys Phe Leu Leu
1 5 10 15
Phe Gly Gly Cys Phe Ala Ile Arg Gln Gln Ser Gln Gln Gln Asn Glu
20 25 30
Cys Gln Leu Glu Arg Leu Asn Ala Leu Lys Pro Asp Asn Arg Ile Glu
35 40 45
Ser Glu Ala Gly Tyr Ile Glu Thr Trp Asn Pro Thr Asn Asn Gln Phe
50 55 60
Arg Cys Ala Gly Val Ala Leu Ser Arg Cys Thr Leu Arg Arg Asn Gly
65 70 75 80
Leu Lys Arg Pro Ser Tyr Ser Asn Ala Pro Gln Glu Ile Phe Ile Gln
85 90 95
Gln Gly Ser Gly Ile Phe Gly Met Ile Phe Pro Gly Cys Pro Glu Thr
100 105 110
Val Glu Glu Pro Phe Glu Ser Asp Gln Gln Gly Arg Arg Asp Arg His
115 120 125
Gln Lys Val Asn Arg Phe Arg Glu Gly Asp Val Ile Ala Val Pro Pro
130 135 140
Gly Val Val Phe Trp Met Tyr Asn Glu Glu Glu Thr Pro Val Ile Ala
145 150 155 160
Val Ser Leu Ile Asp Thr Gly Ser Tyr Leu Asn Gln Leu Asp Gln Met
165 170 175
Pro Arg Arg Phe Tyr Leu Ser Gly Asn Gln Glu Gln Glu Phe Leu Gln
180 185 190
Tyr Gln Arg Gln Glu Val Arg Gly Arg Glu Glu Glu Asn Gln Gly Gly
195 200 205
Asn Ile Phe Ser Gly Phe Gly Gly Glu Phe Leu Glu Asp Ala Leu Asn
210 215 220
Ile Asp Arg Asn Ile Val His Lys Leu Gln Gly Arg Asp Glu Glu Gln
225 230 235 240
Asp Lys Gly Ala Ile Val Arg Val Lys Gly Gly Leu Ser Val Ile Thr
245 250 255
Pro Pro Glu Arg Gln Ser His Arg Arg Gly Ser Glu Glu Glu Glu Asp
260 265 270
Glu Glu Glu Asp Arg Pro Ser Arg His Gln Ser Arg Gly Gly Ser Arg
275 280 285
Arg Asn Gly Leu Glu Glu Thr Ile Cys Thr Val Arg Leu Arg Met Asn
290 295 300
Ile Gly Lys Ser Ser Ser Pro Asp Ile Phe Asn Pro Gln Ala Gly Arg
305 310 315 320
Ile Lys Thr Ala Thr Gly Phe Asp Phe Pro Ala Leu Arg Phe Leu Lys
325 330 335
Leu Ser Ala Glu His Gly Ser Leu Asn Arg Asn Ala Met Val Val Pro
340 345 350
His Tyr Asn Leu Asn Ala Asn Ser Ile Ile Tyr Ala Leu Arg Gly Arg
355 360 365
Ala Trp Ile Gln Val Val Asn Cys Lys Gly Asn Arg Ile Phe Asp Gly
370 375 380
Glu Leu Glu Glu Gly Gln Val Leu Ile Val Pro Gln Asn Phe Val Val
385 390 395 400
Ala Ala Arg Ser Met Ser Asp Lys Phe Asn Tyr Val Ala Phe Lys Thr
405 410 415
Asn Asp Met Pro Thr Met Ala Lys Leu Ala Gly Ala Thr Ser Glu Ile
420 425 430
Gln Ala Met Pro Leu Glu Val Ile Gln Asn Ala Phe Asn Leu Glu Arg
435 440 445
Glu Gln Ala Lys Gln Val Lys Phe Asn Asn Arg Phe Asn Phe Leu Val
450 455 460
Pro Pro Arg Glu Gln Ser Gln Arg Arg Ala Ser Ala
465 470 475
<210> 231
<211> 526
<212> PRT
<213> 埃塞俄比亚豌豆
<400> 231
Met Ala Thr Thr Val Glu Ser Arg Phe Pro Leu Leu Leu Phe Pro Gly
1 5 10 15
Ile Ile Phe Leu Ala Ser Val Cys Val Thr Tyr Ala Asn Tyr Asp Glu
20 25 30
Gly Ser Glu Thr Arg Val Pro Gly Gln Arg Glu Arg Gly Arg Gln Glu
35 40 45
Gly Glu Lys Glu Glu Lys Arg His Gly Glu Trp Arg Pro Ser Tyr Glu
50 55 60
Lys Glu Glu Asp Glu Glu Glu Lys Gln Lys Tyr Arg Tyr Gln Arg Glu
65 70 75 80
Lys Glu Asp Glu Glu Glu Lys Gln Lys Tyr Arg Tyr Gln Arg Glu Lys
85 90 95
Lys Glu Glu Lys Glu Val Gln Pro Gly Arg Glu Arg Trp Glu Arg Glu
100 105 110
Glu Asp Glu Glu Gln Val Asp Glu Glu Trp Arg Gly Ser Gln Arg Arg
115 120 125
Gln Asp Pro Glu Glu Arg Ala Arg Leu Arg His Arg Glu Glu Arg Thr
130 135 140
Lys Arg Asp Arg Arg His Lys Arg Glu Gly Glu Glu Glu Glu Arg Ser
145 150 155 160
Ser Glu Ser Gln Glu Gln Arg Asn Pro Phe Leu Phe Lys Ser Asn Lys
165 170 175
Phe Leu Thr Leu Phe Glu Asn Glu Asn Gly His Ile Arg Arg Leu Gln
180 185 190
Arg Phe Asp Lys Arg Ser Asp Leu Phe Glu Asn Leu Gln Asn Tyr Arg
195 200 205
Leu Val Glu Tyr Arg Ala Lys Pro His Thr Ile Phe Leu Pro Gln His
210 215 220
Ile Asp Ala Asp Leu Ile Leu Val Val Leu Asn Gly Lys Ala Ile Leu
225 230 235 240
Thr Val Leu Ser Pro Asn Asp Arg Asn Ser Tyr Asn Leu Glu Arg Gly
245 250 255
Asp Thr Ile Lys Ile Pro Ala Gly Thr Thr Ser Tyr Leu Val Asn Gln
260 265 270
Asp Asp Glu Glu Asp Leu Arg Val Val Asp Phe Val Ile Pro Val Asn
275 280 285
Arg Pro Gly Lys Phe Glu Ala Phe Gly Leu Ser Glu Asn Lys Asn Gln
290 295 300
Tyr Leu Arg Gly Phe Ser Lys Asn Ile Leu Glu Ala Ser Leu Asn Thr
305 310 315 320
Lys Tyr Glu Thr Ile Glu Lys Val Leu Leu Glu Glu Gln Glu Lys Lys
325 330 335
Pro Gln Gln Leu Arg Asp Arg Lys Arg Arg Gln Gln Gly Gly Glu Arg
340 345 350
Asp Ala Ile Ile Lys Val Ser Arg Glu Gln Ile Glu Glu Leu Arg Lys
355 360 365
Leu Ala Lys Ser Ser Ser Lys Lys Ser Leu Pro Ser Glu Phe Glu Pro
370 375 380
Phe Asn Leu Arg Ser His Lys Pro Glu Tyr Ser Asn Lys Phe Gly Lys
385 390 395 400
Leu Phe Glu Ile Thr Pro Glu Lys Lys Tyr Pro Gln Leu Gln Asp Leu
405 410 415
Asp Ile Leu Val Ser Cys Val Glu Ile Asn Lys Gly Ala Leu Met Leu
420 425 430
Pro His Tyr Asn Ser Arg Ala Ile Val Val Leu Leu Val Asn Glu Gly
435 440 445
Lys Gly Asn Leu Glu Leu Leu Gly Leu Lys Asn Glu Gln Gln Glu Arg
450 455 460
Glu Asp Arg Lys Glu Arg Asn Asn Glu Val Gln Arg Tyr Glu Ala Arg
465 470 475 480
Leu Ser Pro Gly Asp Val Val Ile Ile Pro Ala Gly His Pro Val Ala
485 490 495
Ile Ser Ala Ser Ser Asn Leu Asn Leu Leu Gly Phe Gly Thr Asn Ala
500 505 510
Glu Asn Asn Gln Arg Asn Phe Leu Ser Gly Ser Asp Asp Asn
515 520 525
<210> 232
<211> 541
<212> PRT
<213> 山黧豆葵
<400> 232
Met Ala Thr Thr Ile Lys Ser Arg Phe Pro Leu Leu Leu Leu Leu Gly
1 5 10 15
Ile Ile Phe Leu Ala Ser Val Cys Val Thr Trp Ala Asn Tyr Asp Glu
20 25 30
Gly Ser Glu Pro Arg Val Pro Gly Gln Arg Glu Arg Gly Arg Gln Glu
35 40 45
Gly Glu Lys Glu Glu Lys Arg His Gly Glu Trp Arg Pro Ser Tyr Glu
50 55 60
Glu Glu Tyr Asp Glu Gly Leu Glu Pro Lys Val Pro Gly Lys Arg Glu
65 70 75 80
Arg Gly Arg Gln Glu Gly Glu Lys Glu Glu Lys Arg His Glu Glu Trp
85 90 95
Arg Pro Ser Tyr Glu Lys Glu Glu Asp Glu Glu Glu Lys Gln Lys Tyr
100 105 110
Asn Tyr Gln Arg Glu Lys Lys Glu His Lys Glu Val Gln Pro Gly Arg
115 120 125
Glu Arg Trp Glu Arg Lys Gln Asp Glu Lys Gln Val Glu Glu Asp Glu
130 135 140
Glu Pro Gly Glu Glu Gln Trp Arg Gly Ser Lys Arg His Glu Asp Pro
145 150 155 160
Glu Glu Arg Ala Arg Leu Arg His Arg Glu Glu Lys Thr Lys Ser Tyr
165 170 175
Val Glu Asp Asn Glu Glu Thr Ser Ser Lys Glu Gly Arg Asn Pro Phe
180 185 190
Leu Phe Lys Ser Asn Lys Phe Leu Thr Leu Phe Glu Asn Glu Asn Gly
195 200 205
His Ile Arg Arg Leu Gln Arg Phe Asp Glu Arg Ser Asp Ile Phe Glu
210 215 220
Asn Leu Gln Asn Tyr Arg Leu Val Glu Tyr Arg Ala Lys Pro His Thr
225 230 235 240
Met Phe Leu Pro Gln His Ile Asp Ala Asp Leu Ile Leu Val Val Leu
245 250 255
Asn Gly Lys Ala Ile Leu Thr Val Leu Ser Pro Asn Asp Arg Asn Ser
260 265 270
Tyr Asn Leu Glu Arg Gly Asp Thr Val Lys Leu Pro Ala Gly Thr Thr
275 280 285
Ser Tyr Leu Val Asn Gln Asp Asp Glu Glu Asp Leu Arg Val Val Asp
290 295 300
Leu Ala Ile Pro Val Asn Arg Pro Gly Lys Phe Glu Ala Phe Gly Leu
305 310 315 320
Ser Ala Asn Lys Asn Gln Tyr Leu Arg Gly Phe Ser Lys Asn Ile Leu
325 330 335
Glu Ala Ser Leu Asn Thr Lys Tyr Glu Thr Ile Glu Lys Val Leu Leu
340 345 350
Glu Glu Arg Arg Asp Gln Lys Gly Arg Gln Gln Gly Gln Glu Thr Asn
355 360 365
Ala Ile Val Lys Val Ser Arg Glu Gln Ile Glu Glu Leu Arg Lys Leu
370 375 380
Ala Lys Ser Ser Ser Lys Lys Ser Leu Leu Ser Glu Ser Glu Pro Leu
385 390 395 400
Asn Leu Arg Ser Gln Asn Pro Lys Tyr Ser Asn Lys Phe Gly Lys Phe
405 410 415
Phe Glu Ile Thr Pro Gln Lys Lys Tyr Pro Gln Leu Gln Asp Leu Asp
420 425 430
Val Ser Ile Ser Cys Val Glu Ile Asn Lys Gly Ala Leu Leu Leu Pro
435 440 445
His Tyr Asn Ser Arg Ser Ile Gly Ile Leu Leu Val Asn Glu Gly Lys
450 455 460
Gly Asn Leu Glu Leu Val Gly Phe Lys Asn Glu Gln Gln Arg Gln Arg
465 470 475 480
Glu Asn Glu Glu Thr Asn Lys Lys Leu Gln Arg Tyr Glu Ala Arg Leu
485 490 495
Ser Ser Gly Asp Val Val Val Ile Pro Glu Gly His Pro Val Ala Ile
500 505 510
Ser Ala Ser Ser Asn Leu Asn Leu Leu Gly Phe Gly Ile Asn Ala Ala
515 520 525
Asn Asn Gln Arg Asn Phe Leu Thr Gly Ser Asp Asp Asn
530 535 540
<210> 233
<211> 589
<212> PRT
<213> 长柔野豌豆
<400> 233
Met Ala Thr Thr Ile Lys Ser Arg Phe Pro Val Leu Leu Leu Leu Gly
1 5 10 15
Ile Ile Phe Leu Thr Ser Val Cys Val Thr Tyr Ala Asn Tyr Asp Glu
20 25 30
Gly Arg Glu Pro Ser Val Pro Gly Gln Arg Glu Arg Gly Arg Gln Glu
35 40 45
Gly Glu Lys Glu Glu Lys Arg His Gly Glu Trp Arg Pro Ser Glu Glu
50 55 60
Asp Glu Glu Glu Lys Tyr Lys Tyr Glu Glu Gly Arg Val Pro Gly Gln
65 70 75 80
Arg Glu Arg Gly Arg Gln Glu Gly Glu Lys Glu Glu Lys Arg His Gly
85 90 95
Lys Trp Arg Pro Ser Glu Glu Glu Asp Glu Glu Glu Lys Tyr Arg Tyr
100 105 110
Glu Glu Gly Ser Glu Pro Arg Gly Pro Gly Gln Arg Glu Thr Gly Arg
115 120 125
Gln Glu Gly Glu Lys Glu Lys Gln Arg Pro Glu Arg Glu Pro Ser Tyr
130 135 140
Glu Lys Glu Glu Asp Glu Glu Glu Lys Gln Lys Tyr Gln Tyr His Arg
145 150 155 160
Glu Lys Lys Glu Gln Arg Glu Val Arg Pro Gly Arg Glu Arg Phe Glu
165 170 175
Arg His Glu Asp Glu Glu Gln Trp Arg Gly Ile Gln Arg His Glu Asp
180 185 190
Pro Glu Glu Arg Ala Arg Glu Arg Tyr Arg Ala Glu Ile Ala Lys Arg
195 200 205
Gln Val Glu Glu Glu Arg Glu Glu Arg Asp Ile Pro His Glu Arg Glu
210 215 220
Gln Arg Asn Pro Phe Leu Phe Lys Ser Asn Lys Phe Gln Thr Leu Phe
225 230 235 240
Gln Asn Glu Asn Gly Tyr Ile Arg Arg Leu Gln Arg Phe Asp Lys Arg
245 250 255
Ser Asp Leu Phe Glu Asn Leu Gln Asn Tyr Arg Leu Val Glu Tyr Arg
260 265 270
Ala Lys Pro His Thr Ile Phe Leu Pro Gln His Ile Asp Ala Asp Leu
275 280 285
Ile Ile Val Val Leu Ser Gly Arg Ala Ile Leu Thr Val Leu Ser Pro
290 295 300
Asp Asp Arg Asn Ser Tyr Asn Leu Glu Arg Gly Asp Thr Ile Lys Leu
305 310 315 320
Pro Ala Gly Thr Thr Ser Tyr Leu Val Asn Gln Asp Asp Glu Glu Asp
325 330 335
Leu Arg Val Val Asp Leu Ala Ile Pro Val Asn Arg Pro Gly Lys Val
340 345 350
Glu Ser Phe Leu Leu Ser Gly Asn Lys Asn Gln Tyr Leu Arg Gly Phe
355 360 365
Ser Lys Asn Ile Leu Glu Ala Ser Phe Asn Thr Asn Tyr Glu Thr Ile
370 375 380
Glu Arg Val Leu Leu Glu Glu Gln Asp Lys Glu Ser Gln Gln Ser Ile
385 390 395 400
Gly Gln Lys Arg Arg Ser Gln Arg Gln Glu Thr Asn Ala Leu Val Lys
405 410 415
Val Ser Arg Glu Gln Leu Glu Asp Leu Lys Arg Leu Ala Lys Ser Ser
420 425 430
Ser Gln Glu Gly Leu Ser Ser Gln Phe Glu Pro Ile Asn Leu Arg Ser
435 440 445
Gln Asn Pro Lys Tyr Ser Asn Lys Phe Gly Lys Val Phe Glu Ile Thr
450 455 460
Pro Glu Lys Lys Tyr Pro Gln Leu Gln Asp Leu Asp Leu Phe Val Ser
465 470 475 480
Ser Val Asp Ile Lys Glu Gly Ala Leu Met Leu Pro His Tyr Asn Ser
485 490 495
Arg Ala Ile Val Val Leu Leu Val Asn Glu Gly Arg Gly Asn Leu Glu
500 505 510
Leu Val Gly Leu Lys Asn Glu Gln Gln Glu Gln Arg Glu Lys Glu Asp
515 520 525
Glu Gln Gln Glu Arg Asn Asn Gln Val Gln Arg Tyr Glu Ala Arg Leu
530 535 540
Ser Pro Gly Asp Val Val Ile Ile Pro Ala Gly His Pro Val Ala Val
545 550 555 560
Arg Ala Ser Ser Asp Leu Asn Leu Leu Ala Phe Gly Ile Asn Ala Glu
565 570 575
Asn Asn Gln Arg Asn Phe Leu Ala Gly Ser Asp Asp Asn
580 585
<210> 234
<211> 463
<212> PRT
<213> 蒺藜苜蓿
<400> 234
Met Ala Ile Lys Ala Pro Phe Gln Leu Leu Met Leu Leu Gly Ile Phe
1 5 10 15
Phe Leu Ala Ser Val Cys Val Ser Ser Arg Asp Asp Arg His Asp Gln
20 25 30
Glu Asn Pro Phe Phe Phe Asn Ala Asn His Phe Gln Thr Leu Phe Glu
35 40 45
Asn Glu Asn Gly His Ile Arg Leu Leu Gln Arg Phe Asp Lys Arg Ser
50 55 60
Lys Ile Phe Glu Asn Leu Gln Asn Tyr Arg Leu Leu Glu Tyr His Ser
65 70 75 80
Lys Pro His Thr Leu Phe Leu Pro Gln His Asn Asp Ala Asp Phe Ile
85 90 95
Leu Ala Val Leu Ser Gly Lys Ala Ile Leu Thr Val Leu Asn Pro Asp
100 105 110
Asn Arg Asn Ser Phe Asn Leu Glu Arg Gly Asp Thr Ile Lys Leu Pro
115 120 125
Ala Gly Ser Ile Ala Tyr Leu Ala Asn Arg Asp Asp Asn Glu Asp Leu
130 135 140
Arg Val Leu Asp Leu Ala Ile Pro Val Asn Arg Pro Gly Lys Phe Gln
145 150 155 160
Ser Phe Ser Leu Ser Gly Ser Gln Asn Gln Gln Ser Phe Phe Ser Gly
165 170 175
Phe Ser Lys Asn Ile Leu Glu Ala Ala Phe Asn Ala Asn Tyr Glu Glu
180 185 190
Ile Glu Arg Val Leu Ile Glu Glu His Glu Gln Glu Pro Gln His Arg
195 200 205
Arg Gly Leu Arg Lys Asp Arg Arg Gln Gln Ser Gln Asp Ser Asn Val
210 215 220
Ile Val Lys Val Ser Arg Glu Gln Ile Glu Glu Leu Ser Arg His Ala
225 230 235 240
Lys Ser Ser Ser Arg Arg Ser Gly Ser Ser Glu Ser Ala Pro Phe Asn
245 250 255
Leu Arg Ser Arg Glu Pro Ile Tyr Ser Asn Glu Phe Gly Asn Phe Phe
260 265 270
Glu Ile Thr Pro Glu Lys Asn Pro Gln Leu Lys Asp Leu Asp Ile Leu
275 280 285
Val Asn Tyr Ala Glu Ile Arg Glu Gly Ser Leu Leu Leu Pro His Phe
290 295 300
Asn Ser Arg Ala Thr Val Ile Val Val Val Asp Glu Gly Lys Gly Glu
305 310 315 320
Phe Glu Leu Val Gly Gln Arg Asn Glu Asn Gln Gln Glu Gln Arg Glu
325 330 335
Glu Asp Glu Gln Gln Glu Glu Glu Arg Ser Gln Gln Val Gln Arg Tyr
340 345 350
Arg Ala Arg Leu Ser Pro Gly Asp Val Tyr Val Ile Pro Ala Gly His
355 360 365
Pro Thr Val Val Ser Ala Ser Ser Asp Leu Ser Leu Leu Gly Phe Gly
370 375 380
Ile Asn Ala Glu Asn Asn Glu Arg Asn Phe Leu Ala Gly Glu Glu Asp
385 390 395 400
Asn Val Ile Ser Gln Ile Glu Arg Pro Val Lys Glu Val Ala Phe Pro
405 410 415
Gly Ser Ala Gln Asp Val Glu Ser Leu Leu Lys Asn Gln Arg Gln Ser
420 425 430
Tyr Phe Ala Asn Ala Gln Pro Gln Gln Arg Glu Arg Glu Glu Gly Arg
435 440 445
Ser Gln Arg Gln Arg Glu Leu Ile Ser Ser Ile Leu Gly Val Phe
450 455 460
<210> 235
<211> 499
<212> PRT
<213> 游隼野豌豆
<400> 235
Met Ala Thr Thr Phe Lys Ser Arg Phe Ser Leu Leu Leu Leu Leu Gly
1 5 10 15
Ile Ile Phe Leu Ala Phe Val Cys Val Thr Cys Ala Asn Tyr Asp Glu
20 25 30
Gly Ser Glu Pro Arg Val Pro Gly Gln Arg Glu Arg Gly Arg Gln Glu
35 40 45
Gly Glu Lys Glu Glu Gln Ser Arg Glu Arg His Pro Gln Arg Glu Pro
50 55 60
Ser Arg Glu Lys Glu Glu Asp Glu Glu Glu Lys Gln Lys Tyr Asp Glu
65 70 75 80
Gly Thr Glu Pro Arg Val Pro Gly Gln Arg Glu Arg Gly Arg Gln Glu
85 90 95
Gly Glu Lys Glu Glu Gln Arg Arg Glu Arg His Pro Gly Gln Arg Glu
100 105 110
Pro Ser Gln Glu Glu Asp Glu Glu Arg Glu Glu Ser Asp Arg Arg Gln
115 120 125
Glu Gly Ser Ser Lys Ser Glu Glu Gln Arg Asn Pro Phe Leu Phe Lys
130 135 140
Ser Asn Lys Phe Leu Thr Leu Phe Gln Asn Gly Asn Gly His Ile Arg
145 150 155 160
Leu Leu Gln Arg Phe Asp Lys Arg Ser Asp Leu Phe Glu Asn Leu Gln
165 170 175
Asn Tyr Arg Leu Leu Glu Tyr Arg Ala Lys Pro His Thr Ile Phe Leu
180 185 190
Pro Gln His Ile Asp Ala Asp Leu Ile Leu Val Val Leu Ser Gly Arg
195 200 205
Ala Ile Leu Thr Val Leu Ser Pro Asp Asp Arg Asn Ser Tyr Asn Leu
210 215 220
Glu Arg Gly Asp Thr Ile Lys Leu Pro Ala Gly Thr Thr Ser Tyr Pro
225 230 235 240
Leu Asn Gln Asp Asp Glu Glu Asp Leu Arg Val Val Asp Leu Ala Ile
245 250 255
Ser Val Asn Arg Pro Gly Lys Val Glu Ser Phe Asn Leu Ser Gly Asn
260 265 270
Lys Asn Gln Tyr Leu Arg Gly Phe Ser Glu Asn Ile Leu Glu Ala Ser
275 280 285
Phe Asn Thr Lys Tyr Glu Thr Ile Glu Lys Val Leu Leu Glu Glu Gln
290 295 300
Asp Lys Glu Ser Gln Gln Pro Arg Gly Gln Arg Leu Gln Arg Gln Glu
305 310 315 320
Thr Asn Ala Leu Val Lys Val Ser Arg Glu Gln Val Glu Glu Leu Lys
325 330 335
Arg Leu Ala Arg Thr Ser Ser Lys Lys Gly Val Ser Ser Glu Phe Glu
340 345 350
Pro Phe Asn Leu Arg Ser His Gly Pro Lys Tyr Ser Asn Lys Phe Gly
355 360 365
Lys Phe Phe Glu Ile Thr Pro Glu Lys Lys Tyr Pro Gln Leu Gln Asp
370 375 380
Leu Asp Ile Ser Val Ser Ser Val Glu Ile Asn Glu Gly Ala Leu Phe
385 390 395 400
Leu Pro His Tyr Asn Ser Arg Ala Ile Val Val Val Leu Val Asp Glu
405 410 415
Gly Lys Gly Asn Leu Glu Leu Val Gly Phe Lys Asn Glu Gln Gln Glu
420 425 430
Gln Arg Glu Lys Glu Asp Glu Gln Glu Glu Arg Asn Lys Gln Val Gln
435 440 445
Arg Tyr Glu Ala Lys Leu Ser Pro Gly Asp Val Val Ile Ile Pro Ala
450 455 460
Gly His Pro Val Ala Val Ser Ala Ser Ser Asn Leu Asn Leu Leu Gly
465 470 475 480
Phe Gly Ile Asn Ala Glu Asn Asn Gln Arg Asn Phe Leu Thr Gly Ser
485 490 495
Asp Asp Asn
<210> 236
<211> 515
<212> PRT
<213> 黄花豌豆
<400> 236
Met Ala Thr Thr Ile Lys Leu Arg Phe Pro Leu Leu Leu Leu Leu Gly
1 5 10 15
Val Ile Leu Leu Ala Ser Val Cys Val Thr Cys Ala Asn Tyr Asp Glu
20 25 30
Gly Ser Glu Pro Arg Val Pro Gly Arg Pro Glu Gly Glu Lys Glu Glu
35 40 45
Lys His Arg Gly Lys Leu Arg Pro Ser Tyr Glu Lys Glu Glu Asp Glu
50 55 60
Gly Glu Lys Gln Arg Tyr His Tyr Glu Lys Lys Glu Gln Lys Glu Ala
65 70 75 80
Gln Pro Arg Arg Glu Lys Lys Glu Gln Lys Glu Glu Glu Lys Gln Val
85 90 95
Glu Glu Glu Ser Arg Glu Ser Gln Arg Tyr Glu Asp Pro Gly Glu Arg
100 105 110
Ala Arg Glu Arg Tyr Arg Ala Glu Ile Ile Lys Arg Gln Val Glu Lys
115 120 125
Glu Arg Glu Glu Arg Asp Arg Arg His Gln Arg Glu Gly Glu Glu Glu
130 135 140
Glu Gly Ser Ser Lys Ser Arg Asn Pro Phe Leu Phe Lys Ser Asn Asn
145 150 155 160
Phe Leu Thr Leu Phe Glu Asn Glu Asn Gly His Ile Arg Leu Leu Gln
165 170 175
Arg Phe Asp Lys Arg Ser Asp Leu Phe Glu Asn Leu Gln Asn Tyr Arg
180 185 190
Leu Val Glu Tyr Arg Ala Lys Pro His Thr Ile Phe Leu Pro Gln His
195 200 205
Ile Asp Ala Asp Leu Ile Leu Val Val Leu Ser Gly Lys Ala Ile Leu
210 215 220
Thr Val Leu Ser Pro Asn Asn Arg Asn Ser Tyr Asn Leu Lys Arg Gly
225 230 235 240
Asp Thr Ile Lys Leu Pro Ala Gly Thr Thr Ser Tyr Leu Leu Asn Ser
245 250 255
Asp Asp Glu Glu Asp Leu Arg Met Val Asp Leu Ala Ile Ser Val Asn
260 265 270
Arg Pro Gly Lys Val Glu Ser Phe Asn Leu Ser Gly Asn Lys Asn Gln
275 280 285
Tyr Leu Arg Gly Phe Ser Lys Asn Ile Leu Glu Ala Ser Phe Asn Thr
290 295 300
Lys Tyr Glu Thr Ile Glu Lys Val Leu Leu Glu Glu Gln Asp Lys Glu
305 310 315 320
Ser Gln Gln Ser Ile Gly Gln Lys Arg Ile Ser Gln Arg Gln Glu Thr
325 330 335
Asn Ala Leu Val Lys Val Ser Arg Glu Gln Ile Glu Glu Pro Lys Arg
340 345 350
Leu Ala Arg Ser Ser Ser Arg Lys Gly Val Ser Ser Glu Phe Glu Pro
355 360 365
Ile Asn Leu Arg Ser Gln Arg Pro Lys Tyr Ser Asn Lys Phe Gly Lys
370 375 380
Phe Tyr Glu Ile Ser Pro Glu Lys Lys Tyr Pro Gln Leu Gln Asp Leu
385 390 395 400
Asp Val Ser Val Ser Ser Val Glu Ile Asn Glu Gly Ala Leu Leu Leu
405 410 415
Pro His Tyr Asn Ser Arg Ala Ile Val Thr Val Leu Val Asn Glu Gly
420 425 430
Lys Gly Asn Leu Glu Leu Ile Gly Phe Gln Asn Glu Gln Gln Gly Gln
435 440 445
Arg Glu Lys Glu Asp Glu Gln Gln His Glu Arg Asn Lys Gln Val Gln
450 455 460
Arg Tyr Asp Ala Arg Leu Ser Ser Gly Asp Val Val Ile Ile Pro Ala
465 470 475 480
Gly His Pro Val Ala Val Ser Ala Ser Ser Asn Leu Asp Leu Leu Gly
485 490 495
Phe Gly Ile Asn Ala Glu Asn Ser Gln Arg Asn Phe Leu Thr Gly Ser
500 505 510
Asp Asp Asn
515
<210> 237
<211> 494
<212> PRT
<213> 短花药野生稻
<400> 237
Met Ala Thr Thr Thr Phe Ser Arg Phe Ser Ile Tyr Phe Cys Val Leu
1 5 10 15
Leu Leu Cys His Gly Ser Met Ala Gln Leu Phe Ser Pro Thr Leu Asn
20 25 30
Pro Trp His Ser Ser Arg Arg Gly Gly Ser Arg Asp Cys Arg Phe Asp
35 40 45
Arg Leu Gln Ala Phe Glu Pro Leu Arg Arg Val Arg Ser Glu Ala Gly
50 55 60
Val Thr Glu Tyr Phe Asp Glu Arg Asn Glu Gln Phe Gln Cys Thr Gly
65 70 75 80
Thr Phe Val Ile Arg Arg Val Ile Glu Pro Gln Gly Leu Leu Val Pro
85 90 95
Arg Tyr Thr Asn Thr Pro Gly Val Val Tyr Ile Met Gln Gly Arg Gly
100 105 110
Ser Met Gly Leu Thr Phe Pro Gly Cys Pro Ala Thr Tyr Gln Gln Gln
115 120 125
Phe Gln Gln Phe Leu Pro Glu Gly Gln Ser Gln Ser Gln Lys Phe Arg
130 135 140
Asp Glu His Gln Lys Ile His Gln Phe Arg Gln Gly Asp Ile Val Ala
145 150 155 160
Leu Pro Ala Gly Val Ala His Trp Phe Tyr Asn Glu Gly Asp Thr Pro
165 170 175
Val Val Ala Leu Tyr Val Phe Asp Ile Asn Asn Ser Ala Asn Gln Leu
180 185 190
Glu Pro Arg Gln Lys Asp Phe Leu Leu Ala Gly Asn Asn Asn Arg Glu
195 200 205
Gln Gln Val Tyr Gly Arg Ser Ile Glu Lys His Ser Gly Gln Asn Ile
210 215 220
Phe Ser Gly Phe Asn His Glu Leu Leu Ser Glu Ala Leu Gly Ile Ser
225 230 235 240
Thr Leu Ala Ala Lys Arg Leu Gln Gly Gln Asn Asp His Arg Gly Glu
245 250 255
Ile Ile Arg Val Arg Asn Gly Leu Gln Leu Leu Lys Pro Thr Phe Thr
260 265 270
Gln Gln Gln Glu Gln Ala Gln Ser Gln Tyr Gln Val Gln Tyr Ser Glu
275 280 285
Lys Gln Gln Glu Ser Thr Arg Cys Asn Gly Leu Asp Glu Asn Phe Cys
290 295 300
Thr Ile Asn Ala Arg Leu Asn Ile Glu Asn Pro Ser Arg Ala Asp Thr
305 310 315 320
Tyr Asn Pro Arg Ala Gly Arg Ile Thr His Leu Asn Asn Gln Lys Phe
325 330 335
Pro Ile Leu Asn Leu Val Gln Met Ser Ala Thr Arg Val Asn Leu Tyr
340 345 350
Gln Asn Ala Ile Leu Ser Pro Tyr Trp Asn Val Asn Ala His Ser Leu
355 360 365
Val Tyr Met Val Gln Gly His Ala Arg Val Gln Val Val Ser Asn Leu
370 375 380
Gly Lys Thr Val Phe Asn Ser Val Leu Arg Pro Gly Gln Leu Leu Ile
385 390 395 400
Ile Pro Gln His Tyr Val Val Leu Lys Lys Ala Glu Arg Glu Gly Cys
405 410 415
Gln Tyr Ile Ala Phe Lys Thr Asn Ala Asn Ser Ile Val Ser Gln Leu
420 425 430
Ala Gly Lys Asn Ser Ile Leu Arg Ala Met Pro Val Asp Val Val Ala
435 440 445
Asn Ala Tyr Arg Ile Ser Arg Glu Gln Ala Arg Asp Leu Lys Asn Asn
450 455 460
Arg Gly Glu Glu Leu Gly Ala Phe Thr Pro Lys Phe Glu Gln Gln Ser
465 470 475 480
Tyr Pro Gly Leu Ser Asn Glu Ser Glu Ser Glu Ala Ser Glu
485 490
<210> 238
<211> 515
<212> PRT
<213> 燕麦
<400> 238
Met Ala Thr Thr Ser Phe Pro Ser Val Leu Phe Tyr Ser Cys Ile Phe
1 5 10 15
Leu Leu Tyr Asn Gly Ser Met Ala Gln Leu Phe Gly Gln Ser Phe Thr
20 25 30
Pro Trp Gln Ser Ser Arg Gln Gly Gly Leu Lys Gly Cys Lys Phe Asp
35 40 45
Arg Leu Gln Ala Phe Glu Pro Leu Arg Gln Val Arg Ser Gln Ala Gly
50 55 60
Val Thr Glu Tyr Phe Asp Glu Gln Asn Glu Gln Phe Arg Cys Thr Gly
65 70 75 80
Val Phe Val Ile Arg Arg Val Ile Glu Pro Gln Gly Leu Leu Leu Pro
85 90 95
Gln Tyr His Asn Ala Pro Gly Leu Val Tyr Ile Leu Gln Gly Arg Gly
100 105 110
Tyr Thr Gly Leu Thr Phe Pro Gly Cys Pro Ala Thr Phe Gln Gln Gln
115 120 125
Phe Gln Pro Phe Asp Gln Ala Gln Asp Gln Ser Gln Ser His Leu Lys
130 135 140
Asp Glu His Gln Arg Val His Arg Phe Lys Gln Gly Asp Val Ile Ala
145 150 155 160
Leu Pro Ala Gly Ile Val His Trp Gly Tyr Asn Asp Gly Asp Ala Pro
165 170 175
Val Val Ala Ile Tyr Val Phe Asp Val Asn Asn Asn Ala Asn Gln Leu
180 185 190
Glu Pro Arg Gln Lys Glu Phe Leu Leu Ala Gly Asn Asn Lys Glu Asp
195 200 205
Gln Gln Phe Gly Gln Asn Ile Phe Ser Gly Phe Asn Ile Gln Leu Leu
210 215 220
Ser Glu Ala Leu Gly Ile Ser Gln Gln Ala Ala Gln Arg Ile Gln Ser
225 230 235 240
Gln Lys Glu Gln Arg Gly Glu Ile Ile Arg Val Thr Gln Ala Leu Gln
245 250 255
Phe Leu Lys Pro Thr Met Ser Gln Gln Glu Leu Val Glu His Gln Ala
260 265 270
Tyr Gln Pro Ile Gln Ser Gln Glu Gly Gln Ser Thr Gln Tyr Gln Val
275 280 285
Gly Gln Ser Thr Gln Tyr Gln Glu Gly Gln Ser Thr Gln Tyr Gln Ala
290 295 300
Gly Gln Ser Gln Asp Arg Ser Phe Asn Gly Leu Glu Glu Asn Phe Cys
305 310 315 320
Ser Leu Glu Ala Arg Gln Asn Ile Gly Asn Pro Lys Arg Ala Asp Thr
325 330 335
His Asn Pro Arg Ala Gly Arg Ile Thr Arg Leu His Gly Gln Asn Phe
340 345 350
Pro Ile Leu Asn Leu Val Gln Met Ser Ala Thr Arg Val Asn Leu Tyr
355 360 365
Gln Asn Ala Ile Leu Ser Pro Phe Trp Asn Ile Asn Ala His Ser Val
370 375 380
Val Tyr Met Ile Gln Gly His Ala Gln Val Gln Val Val Asn Asn Asn
385 390 395 400
Gly Gln Thr Val Phe Asn Asp Arg Leu Arg Gln Gly Gln Leu Leu Ile
405 410 415
Val Pro Gln His Tyr Val Val Leu Lys Lys Ala Glu Arg Glu Gly Cys
420 425 430
Gln Tyr Ile Ser Phe Lys Thr Asn Pro Asn Ser Met Val Ser His Ile
435 440 445
Ala Gly Lys Ser Ser Ile Leu Arg Ala Leu Pro Val Asp Val Leu Ala
450 455 460
Asn Ala Tyr Arg Ile Ser Arg Gln Glu Ala Arg Asn Leu Lys Asn Asn
465 470 475 480
Arg Gly Gln Glu Ser Gly Val Phe Thr Pro Lys Phe Thr Gln Thr Ser
485 490 495
Phe Gln Pro Tyr Pro Glu Gly Glu Asp Glu Ser Ser Leu Thr Asn Lys
500 505 510
Ala Ser Glu
515
<210> 239
<211> 493
<212> PRT
<213> 二穗短柄草
<400> 239
Met Ala His Thr Ser Phe Ser Ser Val Leu Ser Tyr Phe Cys Ile Phe
1 5 10 15
Leu Leu Phe His Gly Ser Met Ala Gln Val Pro Gly Gln Gly Ser Thr
20 25 30
Trp Gln Ser Pro Arg Gln Gly Gly Ser Arg Glu Cys Ser Phe Asp Arg
35 40 45
Leu Gln Thr Ile Glu Pro Leu Thr Gln Val Arg Ser Gln Ala Gly Leu
50 55 60
Thr Glu Tyr Phe Asp Glu Gln Asn Glu Gln Phe Arg Cys Ala Gly Val
65 70 75 80
Ser Val Ile Arg Arg Val Ile Glu Pro Arg Gly Leu Leu Leu Pro Arg
85 90 95
Tyr His Asn Thr Pro Gly Leu Val Tyr Ile Leu Glu Gly Ser Gly Phe
100 105 110
Val Gly Leu Ala Phe Pro Gly Cys Pro Glu Thr Phe Leu Glu Gln Phe
115 120 125
Gln Gln Ser Arg Gln Thr Gln Ser Thr Leu Gly Gln Ser Gln Cys Gln
130 135 140
Ser Gln Ser Gln Lys Leu Gly Asp Val His Gln Arg Val His Gln Phe
145 150 155 160
Thr Gln Gly Asp Val Val Ala Leu Pro Ala Gly Val Ala His Trp Phe
165 170 175
Tyr Asn Gly Gly Asp Ala Pro Val Val Ala Val Tyr Val Phe Asp Val
180 185 190
Asn Asn Asn Ala Asn Gln Leu Glu Pro Arg Gln Lys Glu Phe Leu Leu
195 200 205
Ala Gly Asn Tyr Asn Gly Val Leu Gln Ser Gly Arg Asn Ile Leu Asn
210 215 220
Gly Leu Asn Ala Gln Leu Leu Ser Gln Ala Phe Gly Ile Asn Glu Gln
225 230 235 240
Thr Ser Arg Ile Ile Gln Asn Gln Asn Asp Gly Arg Gly Glu Ile Val
245 250 255
Arg Val Glu Tyr Gly Leu Gln Phe Leu Thr Pro Val Val Thr Gln Gln
260 265 270
Gln Gln Lys Gln Pro Phe Leu Pro Ile Glu Pro Gln Glu Gly Gln Ser
275 280 285
Ser Arg Asn Gly Leu Glu Glu Asn Phe Cys Ser Leu Glu Pro Arg Gln
290 295 300
Asn Ile Glu Asp Pro Asn Arg Ala Asp Thr Tyr Asn Pro Arg Ala Gly
305 310 315 320
Ser Ile Ala Arg Leu Asn Gly Gln Asn Phe Pro Ile Leu Asn Leu Val
325 330 335
Gln Met Ser Ala Thr Arg Val Asn Leu Gln Lys Asn Ala Ile Val Ser
340 345 350
Pro Phe Trp Asn Ile Asn Ala His Ser Val Val Tyr Val Ile Gln Gly
355 360 365
Gln Ala Ser Val Gln Val Val Asn Asn Gln Gly Arg Asn Val Phe Asn
370 375 380
Gly Leu Leu Arg Arg Gly Gln Leu Leu Ile Ile Pro Gln Asn Tyr Val
385 390 395 400
Val Leu Lys Lys Ala Glu Ser Glu Gly Tyr Gln Tyr Ile Ala Phe Lys
405 410 415
Thr Asn Ala Asn Ser Met Val Ser His Ile Ala Gly Lys Asn Ser Ile
420 425 430
Leu Arg Ala Leu Pro Val Asp Val Ile Ala Asn Ala Tyr Arg Ile Ser
435 440 445
Arg Gln Glu Ala Gln Asn Leu Lys Asn Asn Arg Gly Glu Glu Ile Gly
450 455 460
Val Leu Thr Pro Asn Phe Pro Gln Ser Ser Cys Gln Ser Tyr Pro Ile
465 470 475 480
Gly Asp Val Asp Ser Ser Ser Thr Pro Lys Ala Gln Glu
485 490
<210> 240
<211> 489
<212> PRT
<213> 水稻
<400> 240
Met Ala Gln Phe Ser Phe Gly Gly Ser Pro Leu Gln Ser Pro Arg Gly
1 5 10 15
Phe Arg Gly Asp Gln Asp Ser Arg His Gln Cys Arg Phe Glu His Leu
20 25 30
Thr Ala Leu Glu Ala Thr His Gln Gln Arg Ser Glu Ala Gly Phe Thr
35 40 45
Glu Tyr Tyr Asn Ile Glu Ala Arg Asn Glu Phe Arg Cys Ala Gly Val
50 55 60
Ser Val Arg Arg Leu Val Val Glu Ser Lys Gly Leu Val Leu Pro Met
65 70 75 80
Tyr Ala Asn Ala His Lys Leu Val Tyr Ile Val Gln Gly Arg Gly Val
85 90 95
Phe Gly Met Ala Leu Pro Gly Cys Pro Glu Thr Phe Gln Ser Val Arg
100 105 110
Ser Pro Phe Glu Gln Glu Val Ala Thr Ala Gly Glu Ala Gln Ser Ser
115 120 125
Ile Gln Lys Met Arg Asp Glu His Gln Gln Leu His Gln Phe His Gln
130 135 140
Gly Asp Val Ile Ala Val Pro Ala Gly Val Ala His Trp Leu Tyr Asn
145 150 155 160
Asn Gly Asp Ser Pro Val Val Ala Phe Thr Val Ile Asp Thr Ser Asn
165 170 175
Asn Ala Asn Gln Leu Asp Pro Lys Arg Arg Glu Phe Phe Leu Ala Gly
180 185 190
Lys Pro Arg Ser Ser Trp Gln Gln Gln Ser Tyr Ser Tyr Gln Thr Glu
195 200 205
Gln Leu Ser Arg Asn Gln Asn Ile Phe Ala Gly Phe Ser Pro Asp Leu
210 215 220
Leu Ser Glu Ala Leu Ser Val Ser Lys Gln Thr Val Leu Arg Leu Gln
225 230 235 240
Gly Leu Ser Asp Pro Arg Gly Ala Ile Ile Arg Val Glu Asn Gly Leu
245 250 255
Gln Ala Leu Gln Pro Ser Leu Gln Val Glu Pro Val Lys Glu Glu Gln
260 265 270
Thr Gln Ala Tyr Leu Pro Thr Lys Gln Leu Gln Pro Thr Trp Leu Arg
275 280 285
Ser Gly Gly Ala Cys Gly Gln Gln Asn Val Leu Asp Glu Ile Met Cys
290 295 300
Ala Phe Lys Leu Arg Lys Asn Ile Asp Asn Pro Gln Ser Ser Asp Ile
305 310 315 320
Phe Asn Pro His Gly Gly Arg Ile Thr Arg Ala Asn Ser Gln Asn Phe
325 330 335
Pro Ile Leu Asn Ile Ile Gln Met Ser Ala Thr Arg Ile Val Leu Gln
340 345 350
Asn Asn Ala Leu Leu Thr Pro His Trp Thr Val Asn Ala His Thr Val
355 360 365
Met Tyr Val Thr Ala Gly Gln Gly His Ile Gln Val Val Asp His Arg
370 375 380
Gly Arg Ser Val Phe Asp Gly Glu Leu His Gln Gln Gln Ile Leu Leu
385 390 395 400
Ile Pro Gln Asn Phe Ala Val Val Val Lys Ala Arg Arg Glu Gly Phe
405 410 415
Ala Trp Val Ser Phe Lys Thr Asn His Asn Ala Val Asp Ser Gln Ile
420 425 430
Ala Gly Lys Ala Ser Ile Leu Arg Ala Leu Pro Val Asp Val Val Ala
435 440 445
Asn Ala Tyr Arg Leu Ser Arg Glu Asp Ser Arg His Val Lys Phe Asn
450 455 460
Arg Gly Asp Glu Met Ala Val Phe Ala Pro Arg Arg Gly Pro Gln Gln
465 470 475 480
Tyr Ala Glu Trp Gln Ile Asn Glu Lys
485
<210> 241
<211> 489
<212> PRT
<213> 水稻
<400> 241
Met Ala Gln Phe Ser Phe Gly Gly Ser Pro Leu Gln Ser Pro Arg Gly
1 5 10 15
Phe Arg Gly Asp Gln Asp Ser Arg His Gln Cys Arg Phe Glu His Leu
20 25 30
Thr Ala Leu Glu Ala Thr His Gln Gln Arg Ser Glu Ala Gly Phe Thr
35 40 45
Glu Tyr Tyr Asn Ile Glu Ala Arg Asn Glu Phe Arg Cys Ala Gly Val
50 55 60
Ser Val Arg Arg Leu Val Val Glu Ser Lys Gly Leu Val Leu Pro Met
65 70 75 80
Tyr Ala Asn Ala His Lys Leu Val Tyr Ile Val Gln Gly Arg Gly Val
85 90 95
Phe Gly Met Ala Leu Pro Gly Cys Pro Glu Thr Phe Gln Ser Val Arg
100 105 110
Ser Pro Phe Glu Gln Glu Val Ala Thr Ala Gly Glu Ala Gln Ser Ser
115 120 125
Met Gln Lys Met Arg Asp Glu His Gln Gln Leu His Gln Phe His Gln
130 135 140
Gly Asp Val Ile Ala Val Pro Ala Gly Val Ala His Trp Leu Tyr Asn
145 150 155 160
Asn Gly Asp Ser Pro Val Val Ala Phe Thr Val Ile Asp Thr Ser Asn
165 170 175
Asn Ala Asn Gln Leu Asp Pro Lys Arg Arg Glu Phe Phe Leu Ala Gly
180 185 190
Lys Pro Arg Ser Ser Trp Gln Gln Gln Ser Tyr Ser Tyr Gln Thr Glu
195 200 205
Gln Leu Ser Arg Asn Gln Asn Ile Phe Ala Gly Phe Asn Pro Asp Leu
210 215 220
Leu Ser Glu Ala Leu Ser Val Ser Lys Gln Thr Val Leu Arg Leu Gln
225 230 235 240
Gly Leu Ser Asp Pro Arg Gly Ala Ile Ile Arg Val Glu Asn Gly Leu
245 250 255
Gln Ala Leu Gln Pro Ser Leu Gln Val Glu Pro Val Lys Glu Glu Gln
260 265 270
Thr Gln Ala Tyr Leu Pro Thr Lys Gln Leu Gln Pro Thr Trp Ser Arg
275 280 285
Ser Gly Gly Ala Cys Gly Gln Gln Asn Gly Leu Asp Glu Ile Met Cys
290 295 300
Ala Phe Lys Leu Arg Lys Asn Ile Asp Asn Pro Gln Ser Ser Asp Ile
305 310 315 320
Phe Asn Pro His Gly Gly Arg Ile Thr Arg Ala Asn Ser Gln Asn Phe
325 330 335
Pro Ile Leu Asn Ile Ile Gln Met Ser Ala Thr Arg Ile Val Leu Gln
340 345 350
Asn Asn Ala Leu Leu Thr Pro His Trp Thr Val Asn Ala His Thr Val
355 360 365
Met Tyr Val Thr Ala Gly Gln Gly Arg Ile Gln Val Val Asp His Arg
370 375 380
Gly Arg Ser Val Phe Asp Gly Glu Leu His Gln Gln Gln Ile Leu Leu
385 390 395 400
Ile Pro Gln Asn Phe Ala Val Val Val Lys Ala Arg Arg Glu Gly Phe
405 410 415
Ala Trp Val Ser Phe Lys Thr Asn His Asn Ala Val Asp Ser Gln Ile
420 425 430
Ala Gly Lys Ala Ser Ile Leu Arg Ala Leu Pro Val Asp Val Val Ala
435 440 445
Asn Ala Tyr Arg Leu Ser Arg Glu Asp Ser Arg Arg Val Lys Phe Asn
450 455 460
Arg Gly Asp Glu Met Ala Val Phe Ala Pro Arg Arg Gly Pro Gln Gln
465 470 475 480
Tyr Ala Glu Trp Gln Ile Asn Glu Lys
485
<210> 242
<211> 504
<212> PRT
<213> 短花药野生稻
<400> 242
Met Val Asp Met Ser Ile Val Val Pro Val Cys Leu Thr Ile Phe Leu
1 5 10 15
Leu Ser Gln Val Cys Ile Ala Gln Val Ser Phe Asp Gly Ser Pro Leu
20 25 30
Tyr Ser Ser Arg Gly Phe Arg Gly Gly Ser Ala Ser Gln Gln Gln Cys
35 40 45
Arg Phe Glu His Leu Ala Ala Leu Glu Val Thr His Gln Glu Lys Ser
50 55 60
Glu Ala Gly Ser Ile Glu Tyr Tyr Asn Thr Glu Ala Arg Asp Glu Phe
65 70 75 80
Arg Cys Ala Arg Val Ser Ala Arg Arg Leu Val Ile Glu Ser Arg Gly
85 90 95
Leu Val Leu Pro Val Tyr Ala Asn Ala His Lys Leu Leu Tyr Ile Val
100 105 110
Gln Gly Arg Gly Val Phe Gly Met Ala Leu Pro Gly Cys Pro Glu Thr
115 120 125
Phe Gln Ser Val Arg Ser Ala Phe Glu Met Ala Thr Gly Asp Ala Glu
130 135 140
Ser Ser Thr Arg Lys Leu Arg Asp Glu His Gln Lys Ile His Gln Phe
145 150 155 160
Arg Gln Gly Asp Val Ile Ala Val Pro Pro Gly Val Ala His Trp Leu
165 170 175
Tyr Asn Asn Gly Asp Ser Pro Val Val Ala Phe Ser Val Ile Asp Phe
180 185 190
Gly Asn Asn Ala Asn Gln Leu Asp Pro Lys Pro Arg Glu Phe Phe Leu
195 200 205
Ala Gly Lys Pro Trp Gly Trp Gln Gln Val Gln Tyr Ser Tyr Gln Ser
210 215 220
Glu Gln Gln Ser Lys His Gln Asn Ile Phe Ala Gly Phe Asn Pro Asp
225 230 235 240
Leu Leu Ala Glu Ala Leu Ser Val Ser Arg Gln Thr Ala Met Arg Leu
245 250 255
Gln Glu Leu Asn Asp Gln Arg Gly Ala Ile Ile Arg Val Glu Gln Gly
260 265 270
Leu Gln Leu Ala Leu Asp Pro Ser Phe Gln Ala Glu Gln Glu Gln Glu
275 280 285
Glu Gln Pro Gln Glu Tyr Leu Ser Ser Gln Gln Gln Gln Pro Thr Trp
290 295 300
Ser Gln Arg Ser Gly Ala Cys Val Gln Asn Asn Gly Leu Asp Glu Ile
305 310 315 320
Met Cys Ala Phe Lys Val Ser Lys Asn Ile Asn Ser Ala Gln Ser Thr
325 330 335
Asp Ile Phe Asn Pro Arg Gly Gly Arg Ile Thr Arg Ala Asn Ser Gln
340 345 350
Asn Phe Pro Val Leu Asn Ile Ile Gln Met Ser Ala Thr Arg Thr Val
355 360 365
Leu Gln Asn Asn Ala Leu Leu Thr Pro His Trp Thr Val Asn Ala His
370 375 380
Thr Val Met Tyr Val Thr Ala Gly Gln Gly Arg Ile Gln Val Val Asp
385 390 395 400
His Arg Gly Arg Thr Val Phe Asp Gly Glu Leu Arg Gln Gln Gln Ile
405 410 415
Leu Leu Ile Pro Gln Asn Phe Ala Val Ala Val Lys Ala Arg His Glu
420 425 430
Gly Phe Ser Trp Val Ser Phe Lys Thr Ser His Asn Ala Ile Asp Ser
435 440 445
Gln Ile Ala Gly Lys Gly Ser Ile Leu Arg Ala Leu Pro Val Asp Val
450 455 460
Leu Ala Lys Ala Tyr Met Leu Ser Arg Glu Glu Ser Arg Thr Leu Lys
465 470 475 480
Tyr Asn Arg Ala Asp Glu Thr Leu Val Phe Ala Pro Arg Pro Glu Ile
485 490 495
Gln Leu Tyr Ala Glu Ser Glu Lys
500
<210> 243
<211> 543
<212> PRT
<213> 豌豆野生种
<400> 243
Met Ala Thr Thr Thr Lys Ser Arg Phe Pro Leu Leu Leu Leu Leu Gly
1 5 10 15
Ile Ile Phe Leu Ala Ser Val Val Cys Val Thr Tyr Ala Asn Tyr Asp
20 25 30
Glu Gly Ser Glu Pro Arg Val Pro Gly Arg Arg Glu Arg Gly Arg Gln
35 40 45
Glu Gly Glu Lys Glu Glu Lys Arg His Gly Glu Trp Arg Pro Ser Tyr
50 55 60
Glu Lys Glu Glu Asp Glu Glu Glu Gly Gln Arg Glu Arg Gly Arg Gln
65 70 75 80
Glu Gly Glu Lys Glu Glu Lys Arg His Gly Glu Trp Gly Pro Ser Tyr
85 90 95
Glu Lys Gln Glu Asp Glu Glu Glu Lys Gln Lys Tyr Arg Tyr Gln Arg
100 105 110
Glu Lys Glu Asp Glu Glu Glu Lys Gln Lys Tyr Arg Tyr Gln Arg Glu
115 120 125
Lys Lys Glu Gln Lys Glu Val Gln Pro Gly Arg Glu Arg Trp Glu Arg
130 135 140
Glu Glu Asp Glu Glu His Val Asp Glu Glu Trp Arg Gly Ser Gln Arg
145 150 155 160
His Glu Asp Pro Glu Glu Arg Ala Arg Leu Arg Tyr Arg Glu Glu Arg
165 170 175
Thr Lys Arg Asp Arg Arg His Gln Arg Glu Gly Glu Glu Glu Glu Arg
180 185 190
Ser Ser Glu Ser Gln Glu Arg Arg Asn Pro Phe Leu Phe Lys Ser Asn
195 200 205
Lys Phe Gln Thr Leu Phe Glu Asn Glu Asn Gly His Ile Arg Leu Leu
210 215 220
Gln Arg Phe Asp Lys Arg Ser Asp Leu Phe Glu Asn Leu Gln Asn Tyr
225 230 235 240
Arg Leu Val Glu Tyr Arg Ala Lys Pro His Thr Ile Phe Leu Pro Gln
245 250 255
His Ile Asp Ala Asp Leu Ile Leu Val Val Leu Ser Gly Lys Ala Ile
260 265 270
Leu Thr Val Leu Ser Pro Asn Ala Arg Asn Ser Tyr Asn Leu Glu Arg
275 280 285
Gly Asp Thr Ile Lys Leu Pro Ala Gly Thr Thr Ser Tyr Leu Val Asn
290 295 300
Gln Asp Asp Glu Glu Asp Leu Arg Leu Val Asp Leu Val Ile Pro Val
305 310 315 320
Asn Gly Pro Gly Lys Phe Glu Ala Phe Asp Leu Ser Lys Asn Lys Asn
325 330 335
Gln Tyr Leu Arg Gly Phe Ser Lys Asn Ile Leu Glu Ala Ser Tyr Asn
340 345 350
Thr Lys Tyr Glu Thr Ile Glu Lys Val Leu Leu Glu Glu Gln Glu Lys
355 360 365
Thr Asp Ala Ile Val Lys Val Ser Arg Glu Gln Ile Glu Glu Leu Arg
370 375 380
Lys His Ala Lys Ser Ser Ser Lys Lys Ile Phe Pro Ser Glu Phe Glu
385 390 395 400
Pro Ile Asn Leu Arg Asn His Lys Pro Glu Tyr Ser Asn Lys Phe Gly
405 410 415
Lys Leu Phe Glu Ile Thr Pro Glu Lys Lys Tyr Pro Gln Leu Gln Asp
420 425 430
Leu Asp Ile Phe Val Ser Cys Val Glu Ile Asn Glu Gly Ala Leu Met
435 440 445
Leu Pro His Tyr Asn Ser Arg Ala Ile Val Val Leu Leu Val Asn Glu
450 455 460
Gly Lys Gly Asn Leu Glu Leu Leu Gly Leu Glu Asn Glu Gln Gln Glu
465 470 475 480
Arg Glu Asp Arg Lys Glu Arg Asn Asn Glu Val Gln Arg Tyr Glu Ala
485 490 495
Arg Leu Ser Pro Gly Asp Val Val Ile Ile Pro Ala Gly His Pro Val
500 505 510
Ala Ile Thr Ala Ser Ser Asn Leu Asn Leu Leu Ala Phe Gly Ile Asn
515 520 525
Ala Glu Asn Asn Gln Arg Asn Phe Leu Ser Gly Ser Asp Asp Asn
530 535 540
<210> 244
<211> 526
<212> PRT
<213> 埃塞俄比亚豌豆
<400> 244
Met Ala Thr Thr Val Glu Ser Arg Phe Pro Leu Leu Leu Phe Pro Gly
1 5 10 15
Ile Ile Phe Leu Ala Ser Val Cys Val Thr Tyr Ala Asn Tyr Asp Glu
20 25 30
Gly Ser Glu Thr Arg Val Pro Gly Gln Arg Glu Arg Gly Arg Gln Glu
35 40 45
Gly Glu Lys Glu Glu Lys Arg His Gly Glu Trp Arg Pro Ser Tyr Glu
50 55 60
Lys Glu Glu Asp Glu Glu Glu Lys Gln Lys Tyr Arg Tyr Gln Arg Glu
65 70 75 80
Lys Glu Asp Glu Glu Glu Lys Gln Lys Tyr Arg Tyr Gln Arg Glu Lys
85 90 95
Lys Glu Glu Lys Glu Val Gln Pro Gly Arg Glu Arg Trp Glu Arg Glu
100 105 110
Glu Asp Glu Glu Gln Val Asp Glu Glu Trp Arg Gly Ser Gln Arg Arg
115 120 125
Gln Asp Pro Glu Glu Arg Ala Arg Leu Arg His Arg Glu Glu Arg Thr
130 135 140
Lys Arg Asp Arg Arg His Lys Arg Glu Gly Glu Glu Glu Glu Arg Ser
145 150 155 160
Ser Glu Ser Gln Glu Gln Arg Asn Pro Phe Leu Phe Lys Ser Asn Lys
165 170 175
Phe Leu Thr Leu Phe Glu Asn Glu Asn Gly His Ile Arg Arg Leu Gln
180 185 190
Arg Phe Asp Lys Arg Ser Asp Leu Phe Glu Asn Leu Gln Asn Tyr Arg
195 200 205
Leu Val Glu Tyr Arg Ala Lys Pro His Thr Ile Phe Leu Pro Gln His
210 215 220
Ile Asp Ala Asp Leu Ile Leu Val Val Leu Asn Gly Lys Ala Ile Leu
225 230 235 240
Thr Val Leu Ser Pro Asn Asp Arg Asn Ser Tyr Asn Leu Glu Arg Gly
245 250 255
Asp Thr Ile Lys Ile Pro Ala Gly Thr Thr Ser Tyr Leu Val Asn Gln
260 265 270
Asp Asp Glu Glu Asp Leu Arg Val Val Asp Phe Val Ile Pro Val Asn
275 280 285
Arg Pro Gly Lys Phe Glu Ala Phe Gly Leu Ser Glu Asn Lys Asn Gln
290 295 300
Tyr Leu Arg Gly Phe Ser Lys Asn Ile Leu Glu Ala Ser Leu Asn Thr
305 310 315 320
Lys Tyr Glu Thr Ile Glu Lys Val Leu Leu Glu Glu Gln Glu Lys Lys
325 330 335
Pro Gln Gln Leu Arg Asp Arg Lys Arg Arg Gln Gln Gly Gly Glu Arg
340 345 350
Asp Ala Ile Ile Lys Val Ser Arg Glu Gln Ile Glu Glu Leu Arg Lys
355 360 365
Leu Ala Lys Ser Ser Ser Lys Lys Ser Leu Pro Ser Glu Phe Glu Pro
370 375 380
Phe Asn Leu Arg Ser His Lys Pro Glu Tyr Ser Asn Lys Phe Gly Lys
385 390 395 400
Leu Phe Glu Ile Thr Pro Glu Lys Lys Tyr Pro Gln Leu Gln Asp Leu
405 410 415
Asp Ile Leu Val Ser Cys Val Glu Ile Asn Lys Gly Ala Leu Met Leu
420 425 430
Pro His Tyr Asn Ser Arg Ala Ile Val Val Leu Leu Val Asn Glu Gly
435 440 445
Lys Gly Asn Leu Glu Leu Leu Gly Leu Lys Asn Glu Gln Gln Glu Arg
450 455 460
Glu Asp Arg Lys Glu Arg Asn Asn Glu Val Gln Arg Tyr Glu Ala Arg
465 470 475 480
Leu Ser Pro Gly Asp Val Val Ile Ile Pro Ala Gly His Pro Val Ala
485 490 495
Ile Ser Ala Ser Ser Asn Leu Asn Leu Leu Gly Phe Gly Thr Asn Ala
500 505 510
Glu Asn Asn Gln Arg Asn Phe Leu Ser Gly Ser Asp Asp Asn
515 520 525
<210> 245
<211> 589
<212> PRT
<213> 长柔毛野豌豆
<400> 245
Met Ala Thr Thr Ile Lys Ser Arg Phe Pro Val Leu Leu Leu Leu Gly
1 5 10 15
Ile Ile Phe Leu Thr Ser Val Cys Val Thr Tyr Ala Asn Tyr Asp Glu
20 25 30
Gly Arg Glu Pro Ser Val Pro Gly Gln Arg Glu Arg Gly Arg Gln Glu
35 40 45
Gly Glu Lys Glu Glu Lys Arg His Gly Glu Trp Arg Pro Ser Glu Glu
50 55 60
Asp Glu Glu Glu Lys Tyr Lys Tyr Glu Glu Gly Arg Val Pro Gly Gln
65 70 75 80
Arg Glu Arg Gly Arg Gln Glu Gly Glu Lys Glu Glu Lys Arg His Gly
85 90 95
Lys Trp Arg Pro Ser Glu Glu Glu Asp Glu Glu Glu Lys Tyr Arg Tyr
100 105 110
Glu Glu Gly Ser Glu Pro Arg Gly Pro Gly Gln Arg Glu Thr Gly Arg
115 120 125
Gln Glu Gly Glu Lys Glu Lys Gln Arg Pro Glu Arg Glu Pro Ser Tyr
130 135 140
Glu Lys Glu Glu Asp Glu Glu Glu Lys Gln Lys Tyr Gln Tyr His Arg
145 150 155 160
Glu Lys Lys Glu Gln Arg Glu Val Arg Pro Gly Arg Glu Arg Phe Glu
165 170 175
Arg His Glu Asp Glu Glu Gln Trp Arg Gly Ile Gln Arg His Glu Asp
180 185 190
Pro Glu Glu Arg Ala Arg Glu Arg Tyr Arg Ala Glu Ile Ala Lys Arg
195 200 205
Gln Val Glu Glu Glu Arg Glu Glu Arg Asp Ile Pro His Glu Arg Glu
210 215 220
Gln Arg Asn Pro Phe Leu Phe Lys Ser Asn Lys Phe Gln Thr Leu Phe
225 230 235 240
Gln Asn Glu Asn Gly Tyr Ile Arg Arg Leu Gln Arg Phe Asp Lys Arg
245 250 255
Ser Asp Leu Phe Glu Asn Leu Gln Asn Tyr Arg Leu Val Glu Tyr Arg
260 265 270
Ala Lys Pro His Thr Ile Phe Leu Pro Gln His Ile Asp Ala Asp Leu
275 280 285
Ile Ile Val Val Leu Ser Gly Arg Ala Ile Leu Thr Val Leu Ser Pro
290 295 300
Asp Asp Arg Asn Ser Tyr Asn Leu Glu Arg Gly Asp Thr Ile Lys Leu
305 310 315 320
Pro Ala Gly Thr Thr Ser Tyr Leu Val Asn Gln Asp Asp Glu Glu Asp
325 330 335
Leu Arg Val Val Asp Leu Ala Ile Pro Val Asn Arg Pro Gly Lys Val
340 345 350
Glu Ser Phe Leu Leu Ser Gly Asn Lys Asn Gln Tyr Leu Arg Gly Phe
355 360 365
Ser Lys Asn Ile Leu Glu Ala Ser Phe Asn Thr Asn Tyr Glu Thr Ile
370 375 380
Glu Arg Val Leu Leu Glu Glu Gln Asp Lys Glu Ser Gln Gln Ser Ile
385 390 395 400
Gly Gln Lys Arg Arg Ser Gln Arg Gln Glu Thr Asn Ala Leu Val Lys
405 410 415
Val Ser Arg Glu Gln Leu Glu Asp Leu Lys Arg Leu Ala Lys Ser Ser
420 425 430
Ser Gln Glu Gly Leu Ser Ser Gln Phe Glu Pro Ile Asn Leu Arg Ser
435 440 445
Gln Asn Pro Lys Tyr Ser Asn Lys Phe Gly Lys Val Phe Glu Ile Thr
450 455 460
Pro Glu Lys Lys Tyr Pro Gln Leu Gln Asp Leu Asp Leu Phe Val Ser
465 470 475 480
Ser Val Asp Ile Lys Glu Gly Ala Leu Met Leu Pro His Tyr Asn Ser
485 490 495
Arg Ala Ile Val Val Leu Leu Val Asn Glu Gly Arg Gly Asn Leu Glu
500 505 510
Leu Val Gly Leu Lys Asn Glu Gln Gln Glu Gln Arg Glu Lys Glu Asp
515 520 525
Glu Gln Gln Glu Arg Asn Asn Gln Val Gln Arg Tyr Glu Ala Arg Leu
530 535 540
Ser Pro Gly Asp Val Val Ile Ile Pro Ala Gly His Pro Val Ala Val
545 550 555 560
Arg Ala Ser Ser Asp Leu Asn Leu Leu Ala Phe Gly Ile Asn Ala Glu
565 570 575
Asn Asn Gln Arg Asn Phe Leu Ala Gly Ser Asp Asp Asn
580 585
<210> 246
<211> 576
<212> PRT
<213> 硬毛山黧豆
<400> 246
Met Ala Ile Ile Ile Lys Ser Arg Phe Pro Leu Leu Leu Leu Leu Gly
1 5 10 15
Ile Ile Phe Leu Ala Ser Val Cys Ala Thr Trp Ala Asn Tyr Asp Glu
20 25 30
Gly Ser Glu Pro Arg Val Pro Gly Gln Arg Glu Arg Gly Arg Gln Glu
35 40 45
Gly Glu Lys Ala Glu Lys Ser His Glu Lys Trp Arg Pro Ser Tyr Glu
50 55 60
Glu Glu Tyr Asp Glu Gly Ser Glu Pro Arg Val Pro Gly Lys Arg Glu
65 70 75 80
Arg Gly Arg Gln Glu Gly Glu Lys Glu Glu Lys Arg His Gly Glu Trp
85 90 95
Arg Pro Ser His Glu Glu Glu Tyr Asp Glu Gly Ser Glu Pro Arg Val
100 105 110
Pro Thr His Gly Glu Arg Gly Arg Gln Glu Gly Glu Lys Glu Glu Lys
115 120 125
Arg His Glu Glu Trp Arg Pro Ser Tyr Glu Lys Glu Glu Asp Glu Glu
130 135 140
Glu Lys Glu Lys Tyr Lys Tyr Gln Arg Glu Lys Lys Glu Gln Lys Glu
145 150 155 160
Val Gln Pro Gly Arg Glu Lys Trp Glu Arg Lys Gln Asp Glu Lys His
165 170 175
Val Glu Glu Asp Glu Asp Gln Glu Glu Glu Gln Trp Arg Gly Ser Lys
180 185 190
Arg Arg Glu Asp Pro Glu Glu Arg Ala Arg Leu Arg Tyr Arg Glu Glu
195 200 205
Arg Thr Lys Ser Asn Val Glu Glu Glu Thr Glu Glu Arg Arg Asn Pro
210 215 220
Phe Leu Phe Lys Ser Asn Lys Phe Leu Thr Leu Phe Glu Asn Glu Asn
225 230 235 240
Gly His Ile Arg Arg Leu Gln Arg Phe Asp Glu Arg Ser Asp Ile Phe
245 250 255
Glu Asn Leu Gln Asn Tyr Arg Leu Val Glu Tyr Lys Ala Lys Pro His
260 265 270
Thr Met Phe Leu Pro Gln His Ile Asp Ala Asp Leu Ile Ile Val Val
275 280 285
Leu Asn Gly Lys Ala Ile Leu Thr Val Leu Ser Pro Asn Asp Arg Asn
290 295 300
Ser Tyr Asn Leu Glu Arg Gly Asp Thr Ile Lys Leu Pro Ala Gly Thr
305 310 315 320
Thr Ser Tyr Leu Val Asn Gln Asp Asp Glu Glu Asp Leu Arg Val Val
325 330 335
Asp Leu Ala Ile Pro Val Asn Arg Pro Gly Lys Phe Glu Ala Phe Gly
340 345 350
Leu Ser Ala Asn Lys Asn Gln Tyr Leu Arg Gly Phe Ser Lys Asn Ile
355 360 365
Leu Glu Ala Phe Leu Asn Thr Lys Tyr Glu Thr Ile Glu Lys Val Leu
370 375 380
Leu Glu Glu Gln Glu Arg Arg Asp Arg Lys Gly Arg Gln Gln Gly Gln
385 390 395 400
Glu Thr Asn Ala Ile Val Lys Val Ser Arg Glu Gln Ile Glu Glu Leu
405 410 415
Arg Lys Leu Ala Lys Ser Ser Ser Lys Lys Ser Leu Leu Ser Glu Ser
420 425 430
Glu Pro Ile Asn Leu Arg Ser Gln Asn Pro Lys Tyr Ser Asn Lys Phe
435 440 445
Gly Lys Leu Phe Glu Ile Thr Pro Glu Lys Lys Tyr Pro Gln Leu Gln
450 455 460
Asp Leu Asp Val Ser Ile Ser Cys Val Glu Ile Asn Glu Gly Ala Pro
465 470 475 480
Leu Leu Pro His Tyr Asn Ser Arg Ala Ile Val Leu Leu Leu Val Asn
485 490 495
Glu Gly Lys Gly Asn Leu Glu Leu Val Gly Phe Lys Asn Glu Gln Gln
500 505 510
Arg Gln Arg Glu Asn Glu Glu Arg Asn Lys Lys Val Gln Arg Tyr Glu
515 520 525
Ala Arg Leu Ser Pro Gly Asp Val Val Val Ile Pro Ala Gly His Pro
530 535 540
Val Ala Ile Ser Ala Ser Leu Asn Leu Asn Leu Val Gly Phe Gly Val
545 550 555 560
Asn Ala Glu Asn Asn Gln Arg Asn Phe Leu Thr Gly Ser Asp Asp Asn
565 570 575
<210> 247
<211> 564
<212> PRT
<213> 扁荚山黧豆
<400> 247
Met Ala Thr Ile Ile Lys Ser Arg Phe Pro Leu Leu Leu Leu Leu Gly
1 5 10 15
Ile Ile Phe Leu Ala Ser Val Cys Val Thr Leu Ala Asn Tyr Asp Glu
20 25 30
Gly Ser Glu Pro Arg Val Pro Ala Gln Arg Glu Arg Gly Arg Gln Glu
35 40 45
Gly Glu Lys Glu Glu Lys Arg His Gly Glu Trp Arg Pro Ser His Glu
50 55 60
Lys Glu Tyr Asp Glu Gly Ser Glu Pro Arg Val Pro Gly Arg Arg Glu
65 70 75 80
Arg Gly Arg Gln Glu Gly Glu Lys Glu Glu Lys Arg His Gly Glu Trp
85 90 95
Arg Pro Ser Tyr Glu Lys Glu Tyr Asp Glu Gly Ser Glu Pro Arg Val
100 105 110
Pro Gly Arg Arg Glu Arg Gly Arg Gln Glu Gly Glu Lys Glu Glu Lys
115 120 125
Arg His Gly Glu Trp Arg Pro Ser Tyr Glu Lys Glu Tyr Asp Glu Glu
130 135 140
Glu Lys Gln Lys Tyr Gln Tyr Glu Arg Glu Lys Glu Glu Gln Lys Glu
145 150 155 160
Val Gln Pro Gly Arg Glu Arg Trp Glu Arg Lys Glu Asp Glu Glu Lys
165 170 175
Glu Glu Asp Gln Trp Arg Gly Ser Gln Arg His Glu Asp Pro Glu Glu
180 185 190
Arg Ala Arg Leu Arg Tyr Arg Lys Glu Arg Thr Lys Lys Tyr Val Glu
195 200 205
Glu Asp Thr Glu Glu Thr Ser Ser Glu Ser Gln Gly Arg Arg Asn Pro
210 215 220
Phe Leu Phe Lys Ser Asn Lys Phe Leu Thr Leu Phe Glu Asn Glu Asn
225 230 235 240
Gly Tyr Ile Arg Arg Leu Gln Arg Phe Asp Glu Arg Ser Asp Ile Phe
245 250 255
Glu Asn Leu Gln Asn Tyr Arg Leu Val Glu Tyr Arg Ala Lys Pro His
260 265 270
Thr Ile Phe Leu Pro Gln His Ile Asp Ala Asp Leu Ile Leu Val Ile
275 280 285
Leu Asn Gly Lys Ala Ile Leu Thr Val Leu Ser Pro Asn Asp Arg Asn
290 295 300
Ser Tyr Asn Leu Glu Arg Gly Asp Thr Ile Lys Leu Pro Ala Gly Thr
305 310 315 320
Thr Ser Tyr Leu Val Asn Glu Asp Asp Glu Glu Asp Leu Arg Val Val
325 330 335
Asp Leu Val Ile Pro Val Asn Arg Pro Gly Lys Phe Glu Ala Phe Asp
340 345 350
Leu Asn Gln Tyr Leu Gly Gly Phe Ser Lys Ser Val Leu Glu Ala Ser
355 360 365
Leu Asn Thr Lys Tyr Glu Thr Ile Glu Lys Val Leu Leu Glu Glu Gln
370 375 380
Gln Lys Gln Gly Gln Glu Thr Asn Ala Ile Val Lys Val Ser Arg Glu
385 390 395 400
Gln Ile Glu Glu Leu Arg Lys Leu Ala Lys Ser Ser Ser Lys Lys Ser
405 410 415
Leu Leu Ser Glu Leu Glu Pro Val Asn Leu Arg Ser His Ser Pro Lys
420 425 430
Tyr Ser Asn Lys Phe Gly Lys Phe Phe Glu Ile Thr Pro Glu Lys Lys
435 440 445
Tyr Pro Gln Leu Gln Asp Leu Asp Val Ser Ile Ser Cys Val Glu Ile
450 455 460
Asn Glu Gly Ala Leu Leu Leu Pro His Tyr Asn Ser Arg Ala Ile Val
465 470 475 480
Val Val Leu Val Asn Glu Gly Lys Gly Asn Leu Glu Leu Leu Gly Val
485 490 495
Gln Asn Glu Asp Glu Gln Gln Glu Arg Lys Glu Arg Asn Lys Glu Val
500 505 510
Gln Arg Tyr Glu Ala Arg Leu Ser Pro Gly Asp Val Val Ile Ile Pro
515 520 525
Ser Gly His Pro Val Ala Val Ser Ala Ser Ser Asn Leu Asn Leu Leu
530 535 540
Gly Phe Gly Ile Asn Ala Glu Asn Asn Gln Arg Asn Phe Leu Ser Gly
545 550 555 560
Ser Asp Asp Asn
<210> 248
<211> 527
<212> PRT
<213> 家山黧豆
<400> 248
Met Ala Thr Ile Ile Lys Ser Arg Phe Pro Leu Leu Leu Leu Leu Gly
1 5 10 15
Ile Ile Phe Leu Ala Ser Val Cys Val Thr Tyr Ala Asn Tyr Asp Glu
20 25 30
Gly Ser Glu Pro Arg Val Pro Ala Gln Arg Glu Arg Gly Arg Gln Glu
35 40 45
Gly Glu Lys Glu Glu Lys Arg His Gly Glu Trp Arg Pro Ser Ser Glu
50 55 60
Lys Glu Tyr Asp Glu Gly Ser Glu Pro Arg Val Pro Gly Arg Arg Glu
65 70 75 80
Arg Gly Arg Gln Glu Gly Glu Lys Glu Glu Lys Arg His Gly Glu Trp
85 90 95
Arg Pro Ser Tyr Glu Lys Glu Tyr Asp Glu Glu Glu Lys Gln Lys Tyr
100 105 110
Gln Tyr Glu Arg Glu Lys Lys Glu Gln Lys Glu Val Glu Pro Gly Arg
115 120 125
Glu Arg Trp Glu Arg Lys Glu Asp Glu Glu Lys Glu Glu Asp Gln Trp
130 135 140
Arg Gly Ser Gln Arg His Glu Asp Pro Glu Glu Arg Ala Arg Leu Arg
145 150 155 160
Tyr Arg Lys Glu Arg Thr Lys Lys Tyr Val Glu Glu Asp Thr Glu Glu
165 170 175
Thr Ser Ser Glu Ser Gln Gly Arg Arg Asn Pro Phe Leu Phe Lys Ser
180 185 190
Asn Lys Phe Leu Thr Leu Phe Glu Asn Glu Asn Gly Tyr Ile Arg Arg
195 200 205
Leu Gln Arg Phe Asp Glu Arg Ser Asp Leu Phe Glu Asn Leu Gln Asn
210 215 220
Tyr Arg Leu Val Glu Tyr Arg Ala Lys Pro His Thr Ile Phe Leu Pro
225 230 235 240
Gln His Ile Asp Ala Asp Leu Ile Leu Val Ile Leu Asn Gly Lys Ala
245 250 255
Ile Leu Thr Val Leu Ser Pro Asn Asp Arg Asn Ser Tyr Asn Leu Glu
260 265 270
Arg Gly Asp Thr Ile Lys Leu Pro Ala Gly Thr Thr Ser Tyr Leu Val
275 280 285
Asn Glu Asp Asp Glu Glu Asp Leu Arg Val Val Asp Leu Val Ile Pro
290 295 300
Val Asn Arg Pro Gly Lys Phe Glu Ala Phe Asp Leu Asn Gln Tyr Leu
305 310 315 320
Gly Gly Phe Ser Lys Ser Val Leu Lys Ala Ser Leu Asn Thr Lys Tyr
325 330 335
Glu Thr Ile Glu Lys Val Leu Leu Glu Glu Gln Gln Lys Gln Gly Gln
340 345 350
Glu Thr Asn Ala Ile Val Lys Val Ser Arg Glu Gln Ile Glu Glu Leu
355 360 365
Arg Lys Leu Ala Lys Ser Ser Ser Lys Lys Ser Leu Leu Ser Glu Leu
370 375 380
Glu Pro Val Asn Leu Arg Ser His Ser Pro Lys Tyr Ser Asn Lys Phe
385 390 395 400
Gly Lys Phe Phe Glu Ile Thr Pro Glu Lys Lys Tyr Pro Gln Leu Gln
405 410 415
Asp Leu Asp Val Ser Ile Ser Cys Val Glu Ile Asn Glu Gly Ala Leu
420 425 430
Leu Leu Pro His Tyr Asn Ser Arg Ala Ile Val Val Leu Leu Val Asn
435 440 445
Glu Gly Lys Gly Asn Leu Glu Leu Leu Gly Val Gln Asp Glu Asp Glu
450 455 460
Gln Gln Glu Arg Lys Lys Arg Asn Lys Glu Val Gln Arg Tyr Glu Ala
465 470 475 480
Arg Leu Ser Pro Ser Asp Val Val Ile Ile Pro Ala Gly His Pro Val
485 490 495
Ala Val Ser Ala Ser Ser Asn Leu Asn Leu Leu Gly Phe Gly Ile Asn
500 505 510
Ala Glu Asn Asn Glu Arg Asn Phe Leu Ser Gly Ser Asp Asp Asn
515 520 525
<210> 249
<211> 495
<212> PRT
<213> 短花药野生稻
<400> 249
Met Ala Thr Thr Val Phe Ser Arg Phe Ser Thr Tyr Phe Cys Val Leu
1 5 10 15
Leu Leu Cys His Gly Ser Met Ala Gln Leu Phe Asn Pro Ser Thr Asn
20 25 30
Pro Trp His Asn Pro Arg Gln Gly Ser Ser Arg Glu Cys Arg Phe Asp
35 40 45
Arg Leu Gln Pro Phe Glu Pro Leu Arg Lys Val Arg Ser Glu Ala Gly
50 55 60
Val Thr Glu Tyr Phe Asp Glu Lys Asn Glu Leu Phe Gln Cys Thr Gly
65 70 75 80
Thr Phe Val Ile Arg Arg Val Ile Gln Pro Gln Gly Leu Leu Val Pro
85 90 95
Arg Tyr Thr Asn Ala Pro Gly Leu Val Tyr Ile Ile Gln Gly Arg Gly
100 105 110
Ser Ile Gly Leu Thr Phe Pro Gly Cys Pro Ala Thr Tyr Gln Gln Gln
115 120 125
Phe Gln Gln Phe Leu Pro Gln Glu Gln Ser Gln Ser Gln Lys Phe Arg
130 135 140
Asp Glu His Gln Lys Ile His Gln Phe Arg Gln Gly Asp Ile Val Ala
145 150 155 160
Leu Pro Ala Gly Val Ala His Trp Phe Tyr Asn Asp Gly Asp Ala Pro
165 170 175
Val Val Ala Val Tyr Val Tyr Asp Val Lys Asn Ser Ala Asn Gln Leu
180 185 190
Glu Pro Arg Gln Arg Glu Phe Leu Leu Gly Gly Asn Asn Met Arg Ala
195 200 205
Gln Gln Val Tyr Gly Ser Ser Ala Glu Gln His Ser Arg Gln Asn Ile
210 215 220
Phe Ser Gly Phe Gly Val Glu Ile Leu Ser Glu Ala Leu Gly Ile Ser
225 230 235 240
Thr Val Thr Thr Lys Arg Leu Gln Ser Gln Asn Asp Gln Arg Gly Glu
245 250 255
Ile Ile His Val Lys Asn Gly Leu Gln Phe Leu Lys Pro Thr Leu Thr
260 265 270
Gln Gln Gln Glu Gln Ala Gln Ala Gln Tyr Gln Glu Val Gln Tyr Ser
275 280 285
Glu Gln Gln Gln Thr Ser Ser Arg Trp Asn Gly Leu Asp Glu Asn Phe
290 295 300
Cys Thr Ile Lys Ala Arg Met Asn Ile Glu Asn Thr Ser Arg Ala Asp
305 310 315 320
Thr Tyr Asn Pro Arg Ala Gly Arg Thr Thr Ser Leu Asn Ser Gln Lys
325 330 335
Phe Pro Ile Leu Asn Leu Val Gln Met Ser Ala Thr Arg Val Asn Leu
340 345 350
Tyr Gln Asn Ala Ile Leu Ser Thr Phe Trp Asn Val Asn Ala His Ser
355 360 365
Leu Val Tyr Thr Ile Gln Gly Arg Ala Arg Val Gln Val Val Ser Asn
370 375 380
Phe Gly Lys Thr Val Phe Asp Gly Glu Leu Arg Pro Gly Gln Leu Leu
385 390 395 400
Ile Ile Pro Gln His Tyr Val Val Leu Lys Lys Ala Gln Arg Glu Gly
405 410 415
Phe Arg Tyr Ile Ala Ile Lys Thr Asn Ala Asn Ala Phe Val Ser Gln
420 425 430
Leu Val Gly Lys Asn Ser Val Phe Arg Ser Leu Pro Val Asp Val Ile
435 440 445
Ala Asn Val Tyr Arg Ile Ser Arg Glu Gln Ala Arg Ser Leu Lys Asn
450 455 460
Asn Arg Gly Glu Glu His Gly Ala Phe Ala Pro Arg Ser Gln Gln Gln
465 470 475 480
Ser Tyr Pro Gly Phe Ser Asn Gln Ser Glu Ser Glu Thr Ser Glu
485 490 495
<210> 250
<211> 494
<212> PRT
<213> 短花药野生稻
<400> 250
Met Ala Thr Thr Thr Phe Ser Arg Phe Ser Ile Tyr Phe Cys Val Leu
1 5 10 15
Leu Leu Cys His Gly Ser Met Ala Gln Leu Phe Ser Pro Thr Leu Asn
20 25 30
Pro Trp His Ser Ser Arg Arg Gly Gly Ser Arg Asp Cys Arg Phe Asp
35 40 45
Arg Leu Gln Ala Phe Glu Pro Leu Arg Arg Val Arg Ser Glu Ala Gly
50 55 60
Val Thr Glu Tyr Phe Asp Glu Arg Asn Glu Gln Phe Gln Cys Thr Gly
65 70 75 80
Thr Phe Val Ile Arg Arg Val Ile Glu Pro Gln Gly Leu Leu Val Pro
85 90 95
Arg Tyr Thr Asn Thr Pro Gly Val Val Tyr Ile Met Gln Gly Arg Gly
100 105 110
Ser Met Gly Leu Thr Phe Pro Gly Cys Pro Ala Thr Tyr Gln Gln Gln
115 120 125
Phe Gln Gln Phe Leu Pro Glu Gly Gln Ser Gln Ser Gln Lys Phe Arg
130 135 140
Asp Glu His Gln Lys Ile His Gln Phe Arg Gln Gly Asp Ile Val Ala
145 150 155 160
Leu Pro Ala Gly Val Ala His Trp Phe Tyr Asn Glu Gly Asp Thr Pro
165 170 175
Val Val Ala Leu Tyr Val Phe Asp Ile Asn Asn Ser Ala Asn Gln Leu
180 185 190
Glu Pro Arg Gln Lys Asp Phe Leu Leu Ala Gly Asn Asn Asn Arg Glu
195 200 205
Gln Gln Val Tyr Gly Arg Ser Ile Glu Lys His Ser Gly Gln Asn Ile
210 215 220
Phe Ser Gly Phe Asn His Glu Leu Leu Ser Glu Ala Leu Gly Ile Ser
225 230 235 240
Thr Leu Ala Ala Lys Arg Leu Gln Gly Gln Asn Asp His Arg Gly Glu
245 250 255
Ile Ile Arg Val Arg Asn Gly Leu Gln Leu Leu Lys Pro Thr Phe Thr
260 265 270
Gln Gln Gln Glu Gln Ala Gln Ser Gln Tyr Gln Val Gln Tyr Ser Glu
275 280 285
Lys Gln Gln Glu Ser Thr Arg Cys Asn Gly Leu Asp Glu Asn Phe Cys
290 295 300
Thr Ile Asn Ala Arg Leu Asn Ile Glu Asn Pro Ser Arg Ala Asp Thr
305 310 315 320
Tyr Asn Pro Arg Ala Gly Arg Ile Thr His Leu Asn Asn Gln Lys Phe
325 330 335
Pro Ile Leu Asn Leu Val Gln Met Ser Ala Thr Arg Val Asn Leu Tyr
340 345 350
Gln Asn Ala Ile Leu Ser Pro Tyr Trp Asn Val Asn Ala His Ser Leu
355 360 365
Val Tyr Met Val Gln Gly His Ala Arg Val Gln Val Val Ser Asn Leu
370 375 380
Gly Lys Thr Val Phe Asn Ser Val Leu Arg Pro Gly Gln Leu Leu Ile
385 390 395 400
Ile Pro Gln His Tyr Val Val Leu Lys Lys Ala Glu Arg Glu Gly Cys
405 410 415
Gln Tyr Ile Ala Phe Lys Thr Asn Ala Asn Ser Ile Val Ser Gln Leu
420 425 430
Ala Gly Lys Asn Ser Ile Leu Arg Ala Met Pro Val Asp Val Val Ala
435 440 445
Asn Ala Tyr Arg Ile Ser Arg Glu Gln Ala Arg Asp Leu Lys Asn Asn
450 455 460
Arg Gly Glu Glu Leu Gly Ala Phe Thr Pro Lys Phe Glu Gln Gln Ser
465 470 475 480
Tyr Pro Gly Leu Ser Asn Glu Ser Glu Ser Glu Ala Ser Glu
485 490
<210> 251
<211> 500
<212> PRT
<213> 菰
<400> 251
Met Asn Met Ala Thr Ile Asn Gly Pro Thr Ile Phe Phe Thr Val Cys
1 5 10 15
Leu Phe Leu Leu Cys His Gly Ser Leu Ala Gln Leu Leu Gly Gln Ser
20 25 30
Thr Ser Gln Trp Gln Ser Ser His Arg Gly Ser Ser Arg Gln Cys Arg
35 40 45
Phe Asp Arg Leu Gln Ala Phe Glu Pro Val Arg Ser Val Arg Ser Gln
50 55 60
Ala Gly Thr Thr Glu Phe Phe Asp Ala Ser Asn Glu Leu Phe Gln Cys
65 70 75 80
Ala Gly Val Ser Ile Val Arg Arg Ile Ile Glu Pro Arg Gly Leu Leu
85 90 95
Leu Pro Gln Tyr Thr Asn Gly Ala Thr Ile Met Tyr Ile Ile Gln Gly
100 105 110
Arg Gly Ile Thr Gly Gln Thr Phe Pro Gly Cys Pro Glu Ser Tyr Gln
115 120 125
Gln Gln Phe Gln Gln Ser Met Gln Ala Gln Leu Thr Gly Ser Gln Ser
130 135 140
Gln Ser Gln Lys Phe Lys Asp Glu His Gln Lys Ile Asn Arg Phe Arg
145 150 155 160
Gln Gly Asp Val Ile Ala Leu Pro Ala Gly Val Ala His Trp Cys Tyr
165 170 175
Asn Asp Gly Glu Val Pro Val Val Ala Ile Tyr Val Ile Asp Ile Asn
180 185 190
Asn Ala Ala Asn Gln Leu Asp Pro Arg Gln Arg Asp Phe Leu Leu Ala
195 200 205
Gly Asn Met Arg Ser Pro Gln Ala Tyr Arg Arg Glu Val Glu Asn Gln
210 215 220
Ser Gln Asn Ile Phe Ser Gly Phe Ser Ala Glu Leu Leu Ser Glu Ala
225 230 235 240
Leu Gly Ile Ser Thr Gly Val Ala Arg Gln Leu Gln Cys Gln Asn Asp
245 250 255
Gln Arg Gly Glu Ile Val Arg Val Glu His Gly Leu Ser Leu Leu Gln
260 265 270
Pro Tyr Ala Ser Leu Gln Glu Gln Glu Gln Lys Gln Glu Gln Pro Arg
275 280 285
Glu Arg Tyr Gln Val Thr Gln His Gln Gln Ser Gln Tyr Gly Gly Gly
290 295 300
Cys Ser Asn Gly Leu Asp Glu Thr Phe Cys Ala Met Arg Ile Trp Gln
305 310 315 320
Asn Ile Asp Asn Pro Asn Leu Ala Asp Thr Tyr Asn Pro Arg Ala Gly
325 330 335
Arg Val Thr Asn Leu Asn Ser Gln Lys Phe Pro Ile Leu Asn Leu Ile
340 345 350
Gln Met Ser Ala Val Lys Val Asn Leu Tyr Gln Asn Ala Leu Leu Ser
355 360 365
Pro Phe Trp Asn Ile Asn Ser His Ser Val Val Tyr Val Thr Gln Gly
370 375 380
Cys Ala Arg Val Gln Val Val Asn Asn Asn Gly Lys Thr Val Phe Asn
385 390 395 400
Gly Glu Leu Arg Arg Gly Gln Leu Leu Ile Ile Pro Gln His Tyr Val
405 410 415
Val Val Lys Lys Ala Gln Arg Glu Gly Cys Ala Tyr Ile Ala Phe Lys
420 425 430
Thr Asn Pro Asn Ser Met Val Ser His Ile Val Gly Lys Ser Ser Ile
435 440 445
Phe Arg Ala Leu Pro Thr Asp Val Leu Ala Asn Ala Tyr Arg Ile Ser
450 455 460
Arg Glu Asp Ala Gln Arg Leu Lys His Asn Arg Gly Asp Glu Leu Gly
465 470 475 480
Ala Phe Thr Pro Leu Gln Tyr Lys Ser Tyr Gln Asp Val Ser Ser Val
485 490 495
Ala Ala Ser Ser
500
<210> 252
<211> 454
<212> PRT
<213> 水稻
<400> 252
Cys Arg Phe Asp Arg Leu Gln Ala Phe Glu Pro Ile Arg Ser Val Arg
1 5 10 15
Ser Gln Ala Gly Thr Thr Glu Phe Phe Asp Val Ser Asn Glu Gln Phe
20 25 30
Gln Cys Thr Gly Val Ser Ala Val Arg Arg Val Ile Glu Pro Arg Gly
35 40 45
Leu Leu Leu Pro His Tyr Thr Asn Gly Ala Ser Leu Val Tyr Ile Ile
50 55 60
Gln Gly Arg Gly Ile Thr Gly Pro Thr Phe Pro Gly Cys Pro Glu Ser
65 70 75 80
Tyr Gln Gln Gln Phe Gln Gln Ser Gly Gln Ala Gln Leu Thr Glu Ser
85 90 95
Gln Ser Gln Ser His Lys Phe Lys Asp Glu His Gln Lys Ile His Arg
100 105 110
Phe Arg Gln Gly Asp Val Ile Ala Leu Pro Ala Gly Val Ala His Trp
115 120 125
Cys Tyr Asn Asp Gly Glu Val Pro Val Val Ala Ile Tyr Val Thr Asp
130 135 140
Leu Asn Asn Gly Ala Asn Gln Leu Asp Pro Arg Gln Arg Asp Phe Leu
145 150 155 160
Leu Ala Gly Asn Lys Arg Asn Pro Gln Ala Tyr Arg Arg Glu Val Glu
165 170 175
Glu Arg Ser Gln Asn Ile Phe Ser Gly Phe Ser Thr Glu Leu Leu Ser
180 185 190
Glu Ala Leu Gly Val Ser Ser Gln Val Ala Arg Gln Leu Gln Cys Gln
195 200 205
Asn Asp Gln Arg Gly Glu Ile Val Arg Val Glu His Gly Leu Ser Leu
210 215 220
Leu Gln Pro Tyr Ala Ser Leu Gln Glu Gln Glu Gln Gly Gln Val Gln
225 230 235 240
Ser Arg Glu Arg Tyr Gln Glu Gly Gln Tyr Gln Gln Ser Gln Tyr Gly
245 250 255
Ser Gly Cys Ser Asn Gly Leu Asp Glu Thr Phe Cys Thr Met Lys Val
260 265 270
Arg Gln Asn Ile Asp Asn Pro Asn Arg Ala Asp Thr Tyr Asn Pro Arg
275 280 285
Ala Gly Arg Val Thr Asn Leu Asn Thr Gln Asn Phe Pro Ile Leu Asn
290 295 300
Leu Val Gln Met Ser Ala Val Lys Val Asn Leu Tyr Gln Asn Ala Leu
305 310 315 320
Leu Ser Pro Phe Trp Asn Ile Asn Ala His Ser Val Val Tyr Ile Thr
325 330 335
Gln Gly Arg Ala Arg Val Gln Val Val Asn Asn Asn Gly Lys Thr Val
340 345 350
Phe Asn Gly Glu Leu Arg Arg Gly Gln Leu Leu Ile Ile Pro Gln His
355 360 365
Tyr Ala Val Val Lys Lys Ala Gln Arg Glu Gly Cys Ala Tyr Ile Ala
370 375 380
Phe Lys Thr Asn Pro Asn Ser Met Val Ser His Ile Ala Gly Lys Ser
385 390 395 400
Ser Ile Phe Arg Ala Leu Pro Asn Asp Val Leu Ala Asn Ala Tyr Arg
405 410 415
Ile Ser Arg Glu Glu Ala Gln Arg Leu Lys His Asn Arg Gly Asp Glu
420 425 430
Phe Gly Ala Phe Thr Pro Ile Gln Tyr Lys Ser Tyr Gln Asp Val Tyr
435 440 445
Asn Ala Ala Glu Ser Ser
450
<210> 253
<211> 500
<212> PRT
<213> 菰
<400> 253
Met Asn Met Ala Thr Ile Asn Gly Pro Thr Ile Phe Phe Thr Val Cys
1 5 10 15
Leu Phe Leu Leu Cys His Gly Ser Leu Ala Gln Leu Leu Gly Gln Ser
20 25 30
Thr Ser Gln Trp Gln Ser Ser His Arg Gly Ser Ser Arg Gln Cys Arg
35 40 45
Phe Asp Arg Leu Gln Ala Phe Glu Pro Val Arg Ser Val Arg Ser Gln
50 55 60
Ala Gly Thr Thr Glu Phe Phe Asp Ala Ser Asn Glu Leu Phe Gln Cys
65 70 75 80
Ala Gly Val Ser Ile Val Arg Arg Ile Ile Glu Pro Arg Gly Leu Leu
85 90 95
Leu Pro Gln Tyr Thr Asn Gly Ala Thr Ile Met Tyr Ile Ile Gln Gly
100 105 110
Arg Gly Ile Thr Gly Gln Thr Phe Pro Gly Cys Pro Glu Ser Tyr Gln
115 120 125
Gln Gln Phe Gln Gln Ser Met Gln Ala Gln Leu Thr Gly Ser Gln Ser
130 135 140
Gln Ser Gln Lys Phe Lys Asp Glu His Gln Lys Ile Asn Arg Phe Arg
145 150 155 160
Gln Gly Asp Val Ile Ala Leu Pro Ala Gly Val Ala His Trp Cys Tyr
165 170 175
Asn Asp Gly Glu Val Pro Val Val Ala Ile Tyr Val Ile Asp Ile Asn
180 185 190
Asn Ala Ala Asn Gln Leu Asp Pro Arg Gln Arg Asp Phe Leu Leu Ala
195 200 205
Gly Asn Met Arg Ser Pro Gln Ala Tyr Arg Arg Glu Val Glu Asn Gln
210 215 220
Ser Gln Asn Ile Phe Ser Gly Phe Ser Ala Glu Leu Leu Ser Glu Ala
225 230 235 240
Leu Gly Ile Ser Thr Gly Val Ala Arg Gln Leu Gln Cys Gln Asn Asp
245 250 255
Gln Arg Gly Glu Ile Val Arg Val Glu His Gly Leu Ser Leu Leu Gln
260 265 270
Pro Tyr Ala Ser Leu Gln Glu Gln Glu Gln Lys Gln Glu Gln Pro Arg
275 280 285
Glu Arg Tyr Gln Val Thr Gln His Gln Gln Ser Gln Tyr Gly Gly Gly
290 295 300
Cys Ser Asn Gly Leu Asp Glu Thr Phe Cys Ala Met Arg Ile Trp Gln
305 310 315 320
Asn Ile Asp Asn Pro Asn Leu Ala Asp Thr Tyr Asn Pro Arg Ala Gly
325 330 335
Arg Val Thr Asn Leu Asn Ser Gln Lys Phe Pro Ile Leu Asn Leu Ile
340 345 350
Gln Met Ser Ala Val Lys Val Asn Leu Tyr Gln Asn Ala Leu Leu Ser
355 360 365
Pro Phe Trp Asn Ile Asn Ser His Ser Val Val Tyr Val Thr Gln Gly
370 375 380
Cys Ala Arg Val Gln Val Val Asn Asn Asn Gly Lys Thr Val Phe Asn
385 390 395 400
Gly Glu Leu Arg Arg Gly Gln Leu Leu Ile Ile Pro Gln His Tyr Val
405 410 415
Val Val Lys Lys Ala Gln Arg Glu Gly Cys Ala Tyr Ile Ala Phe Lys
420 425 430
Thr Asn Pro Asn Ser Met Val Ser His Ile Val Gly Lys Ser Ser Ile
435 440 445
Phe Arg Ala Leu Pro Thr Asp Val Leu Ala Asn Ala Tyr Arg Ile Ser
450 455 460
Arg Glu Asp Ala Gln Arg Leu Lys His Asn Arg Gly Asp Glu Leu Gly
465 470 475 480
Ala Phe Thr Pro Leu Gln Tyr Lys Ser Tyr Gln Asp Val Ser Ser Val
485 490 495
Ala Ala Ser Ser
500
<210> 254
<211> 527
<212> PRT
<213> 燕麦
<400> 254
Met Ala Thr Thr Ser Phe Pro Ser Met Leu Phe Tyr Phe Cys Ile Phe
1 5 10 15
Leu Leu Phe His Gly Ser Met Ala Gln Leu Phe Gly Gln Ser Ser Thr
20 25 30
Pro Trp Gln Ser Ser Arg Gln Gly Gly Leu Arg Gly Cys Arg Phe Asp
35 40 45
Arg Leu Gln Ala Phe Glu Pro Leu Arg Gln Val Arg Ser Gln Ala Gly
50 55 60
Ile Thr Glu Tyr Phe Asp Glu Gln Asn Glu Gln Phe Arg Cys Thr Gly
65 70 75 80
Val Ser Val Ile Arg Arg Val Ile Glu Pro Gln Gly Leu Val Leu Pro
85 90 95
Gln Tyr His Asn Ala Pro Ala Leu Val Tyr Ile Leu Gln Gly Arg Gly
100 105 110
Phe Thr Gly Leu Thr Phe Pro Gly Cys Pro Ala Thr Phe Gln Gln Gln
115 120 125
Phe Gln Pro Phe Asp Gln Ser Gln Phe Ala Gln Gly Gln Arg Gln Ser
130 135 140
Gln Thr Ile Lys Asp Glu His Gln Arg Val Gln Arg Phe Lys Gln Gly
145 150 155 160
Asp Val Val Ala Leu Pro Ala Gly Ile Val His Trp Cys Tyr Asn Asp
165 170 175
Gly Asp Ala Pro Ile Val Ala Ile Tyr Val Phe Asp Val Asn Asn Asn
180 185 190
Ala Asn Gln Leu Glu Pro Arg Gln Lys Glu Phe Leu Leu Ala Gly Asn
195 200 205
Asn Lys Arg Glu Gln Gln Ser Gly Asn Asn Ile Phe Ser Gly Leu Ser
210 215 220
Val Gln Leu Leu Ser Glu Ala Leu Gly Ile Ser Gln Gln Ala Ala Gln
225 230 235 240
Arg Ile Gln Ser Gln Asn Asp Gln Arg Gly Glu Ile Ile Arg Val Ser
245 250 255
Gln Gly Leu Gln Phe Leu Lys Pro Ile Val Ser Gln Gln Val Pro Gly
260 265 270
Glu Gln Gln Val Tyr Gln Pro Ile Gln Thr Gln Glu Gly Gln Ala Thr
275 280 285
Gln Tyr Gln Val Gly Gln Ser Thr Gln Tyr Gln Val Gly Lys Ser Thr
290 295 300
Pro Tyr Gln Gly Gly Gln Ser Ser Gln Tyr Gln Ala Gly Gln Ser Trp
305 310 315 320
Asp Gln Ser Phe Asn Gly Leu Glu Glu Asn Phe Cys Ser Leu Glu Ala
325 330 335
Arg Lys Asn Ile Glu Asn Pro Gln His Ala Asp Thr Tyr Asn Pro Arg
340 345 350
Ala Gly Arg Ile Thr Arg Leu Asn Ser Lys Asn Phe Pro Ile Leu Asn
355 360 365
Ile Val Gln Met Ser Ala Thr Arg Val Asn Leu Tyr Gln Asn Ala Ile
370 375 380
Leu Ser Pro Phe Trp Asn Ile Asn Ala His Ser Val Ile Tyr Met Ile
385 390 395 400
Gln Gly His Ala Arg Val Gln Val Val Asn Asn Asn Gly Gln Thr Val
405 410 415
Phe Asn Asp Ile Leu Arg Arg Gly Gln Leu Leu Ile Val Pro Gln His
420 425 430
Phe Val Val Leu Lys Lys Ala Glu Arg Glu Gly Cys Gln Tyr Ile Ser
435 440 445
Phe Lys Thr Asn Pro Asn Ser Met Val Ser His Ile Ala Gly Lys Ser
450 455 460
Ser Ile Leu Arg Ala Leu Pro Ile Asp Val Leu Ala Asn Ala Tyr Arg
465 470 475 480
Ile Ser Arg Gln Glu Ala Arg Asn Leu Lys Asn Asn Arg Gly Glu Glu
485 490 495
Phe Gly Ala Phe Thr Pro Lys Leu Thr Gln Lys Gly Phe Gln Ser Tyr
500 505 510
Gln Asp Ile Glu Glu Gly Ser Ser Ser Pro Val Arg Ala Ser Glu
515 520 525
<210> 255
<211> 498
<212> PRT
<213> 水稻
<400> 255
Met Ala Ser Thr Asn Arg Pro Ile Val Phe Phe Thr Val Cys Leu Phe
1 5 10 15
Leu Leu Cys Asp Gly Ser Leu Ala Gln Gln Leu Leu Gly Gln Ser Thr
20 25 30
Ser Gln Trp Gln Ser Ser Arg Arg Gly Ser Pro Arg Gly Cys Arg Phe
35 40 45
Asp Arg Leu Gln Ala Phe Glu Pro Ile Arg Ser Val Arg Ser Gln Ala
50 55 60
Gly Thr Thr Glu Phe Phe Asp Val Ser Asn Glu Leu Phe Gln Cys Thr
65 70 75 80
Gly Val Ser Val Val Arg Arg Val Ile Glu Pro Arg Gly Leu Leu Leu
85 90 95
Pro His Tyr Thr Asn Gly Ala Ser Leu Val Tyr Ile Ile Gln Gly Arg
100 105 110
Gly Ile Thr Gly Pro Thr Phe Pro Gly Cys Pro Glu Thr Tyr Gln Gln
115 120 125
Gln Phe Gln Gln Ser Gly Gln Ala Gly Leu Thr Glu Ser Gln Ser Gln
130 135 140
Ser His Lys Phe Lys Asp Glu His Gln Lys Ile His Arg Phe Arg Gln
145 150 155 160
Gly Asp Val Ile Ala Leu Pro Ala Gly Val Ala His Trp Cys Tyr Asn
165 170 175
Asp Cys Glu Val Pro Val Val Ala Ile Tyr Val Thr Asp Ile Asn Asn
180 185 190
Gly Ala Asn Gln Leu Asp Pro Arg Gln Arg Asp Phe Leu Leu Ala Gly
195 200 205
Asn Lys Arg Asn Pro Gln Ala Tyr Arg Arg Glu Val Glu Glu Trp Ser
210 215 220
Gln Asn Ile Phe Ser Gly Phe Ser Thr Glu Leu Leu Ser Glu Ala Phe
225 230 235 240
Gly Ile Ser Asn Gln Val Ala Arg Gln Leu Gln Cys Gln Asn Asp Gln
245 250 255
Lys Gly Glu Ile Val Arg Val Glu Arg Gly Leu Ser Leu Leu Gln Pro
260 265 270
Tyr Ala Ser Leu Gln Glu Gln Glu Gln Gly Gln Met Gln Ser Arg Glu
275 280 285
His Tyr Gln Glu Gly Gly Tyr Gln Gln Ser Gln Tyr Gly Ser Gly Cys
290 295 300
Pro Asn Gly Leu Asp Glu Thr Phe Cys Val Asn Lys Val Arg Gln Asn
305 310 315 320
Ile Asp Asn Pro Asn Arg Ala Asp Thr Tyr Asn Pro Arg Ala Gly Arg
325 330 335
Val Thr Asn Leu Ser Gln Asn Phe Pro Ile Leu Asn Leu Val Gln Met
340 345 350
Ser Ala Val Lys Val Asn Leu Tyr Gln Asn Thr Asp Thr Trp Ile Ser
355 360 365
Met Gly Gln Glu Glu Asn Ala Leu Leu Ser Pro Phe Trp Asn Ile Asn
370 375 380
Ala His Ser Ile Val Tyr Ile Thr Gln Gly Arg Ala Gln Val Gln Val
385 390 395 400
Leu Arg Arg Gly Gln Leu Leu Ile Val Pro Gln His Tyr Val Val Val
405 410 415
Lys Lys Ala Gln Arg Glu Gly Cys Ala Tyr Ile Ala Phe Lys Thr Asn
420 425 430
Pro Asn Ser Met Val Ser His Ile Ala Gly Lys Ser Ser Ile Phe Arg
435 440 445
Ala Leu Pro Thr Asp Val Leu Ala Asn Ala Tyr Arg Ile Ser Arg Glu
450 455 460
Glu Ala Gln Arg Leu Lys His Asn Arg Gly Asp Glu Phe Gly Ala Phe
465 470 475 480
Thr Pro Leu Gln Tyr Lys Ser Tyr Gln Asp Val Tyr Asn Val Ala Glu
485 490 495
Ser Ser
<210> 256
<211> 491
<212> PRT
<213> 短花药野生稻
<400> 256
Met Lys Ser Ser Ile Val Phe Ser Thr Ile Cys Leu Val Leu Leu Cys
1 5 10 15
His Gly Ser Leu Ala Gln Leu Leu Ser Gln Ser Thr Ser Gln Trp Gln
20 25 30
Ser Ser Arg Arg Gly Ser Pro Arg Gln Cys Arg Phe Asp Gln Leu Gln
35 40 45
Ala Phe Glu Pro Ile Arg Thr Val Arg Ser Gln Ala Gly Val Thr Glu
50 55 60
Phe Tyr Asp Val Ser Asn Glu Leu Phe Gln Cys Thr Gly Val Ser Val
65 70 75 80
Val Arg Arg Val Ile Glu Pro Arg Gly Leu Leu Leu Pro His Tyr Ser
85 90 95
Asn Gly Ala Thr Leu Val Tyr Ile Ile Gln Gly Arg Gly Ile Thr Gly
100 105 110
Pro Thr Phe Pro Gly Cys Pro Glu Thr Tyr Gln Gln Gln Phe Gln Gln
115 120 125
Ser Gly Glu Ala Gln Pro Phe Glu Gly Gln Ser His Lys Phe Arg Asp
130 135 140
Glu His Gln Lys Ile His Arg Phe Arg Gln Gly Asp Val Val Ala Leu
145 150 155 160
Pro Ala Gly Val Ala His Trp Cys Tyr Asn Asp Gly Glu Val Pro Ile
165 170 175
Val Ala Ile Tyr Val Thr Asp Ile Tyr Asn Ser Ala Asn Gln Leu Asp
180 185 190
Pro Arg His Arg Asp Phe Phe Leu Ala Gly Asn Asn Lys Val Ala Gln
195 200 205
Gln Leu Tyr Arg Ser Glu Ala Arg Glu Asn Ser Lys Asn Ile Phe Gly
210 215 220
Gly Phe Ser Val Glu Leu Leu Ser Glu Ala Leu Gly Ile Ser Arg Gly
225 230 235 240
Val Ala Arg Gln Leu Gln Cys Gln Asn Asp Gln Arg Gly Glu Ile Val
245 250 255
Arg Val Glu His Gly Leu Ala Leu Leu Gln Pro Tyr Ala Ser Val Gln
260 265 270
Glu Gln Gln Gln Glu Gln Val Gln Ser Arg Asp Tyr Glu Gln Thr Gln
275 280 285
Tyr Gln Gln Lys Gln Pro Gln Gly Ser Cys Ser Asn Gly Leu Asp Glu
290 295 300
Thr Phe Cys Thr Met Arg Leu Arg Gln Asn Ile Asp Asn Pro Asn Leu
305 310 315 320
Ala Asp Thr Tyr Asn Pro Lys Ala Gly Arg Ile Thr Tyr Leu Asn Gly
325 330 335
Gln Lys Phe Pro Ile Leu Asn Leu Val Gln Met Ser Ala Val Lys Val
340 345 350
Asn Leu Tyr Gln Asn Ala Val Leu Ser Pro Phe Trp Asn Ile Asn Ala
355 360 365
His Ser Val Val Tyr Ile Thr Gln Gly Arg Ala Arg Val Gln Val Val
370 375 380
Asn Asn Asn Gly Lys Thr Val Phe Asp Gly Glu Leu Arg Gln Gly Gln
385 390 395 400
Leu Leu Ile Ile Pro Gln His His Val Val Leu Lys Lys Ala Gln Arg
405 410 415
Glu Gly Cys Ser Tyr Ile Ala Leu Lys Thr Asn Pro Asn Ser Ile Val
420 425 430
Ser His Ile Ala Gly Lys Asn Ser Ile Phe Arg Ala Leu Pro Gly Asp
435 440 445
Val Val Thr Asn Ala Tyr Arg Ile Ser Arg Glu Glu Ala Lys Arg Ile
450 455 460
Lys His Asn Arg Gly Asp Glu Ser Gly Val Phe Ala Pro Ser His Ala
465 470 475 480
Tyr Arg Ser Tyr Gln Asp Met Ser Val Ala Ala
485 490
<210> 257
<211> 492
<212> PRT
<213> 二穗短柄草
<400> 257
Met Ala His Thr Ser Phe Ser Ser Phe Leu Ser Tyr Phe Cys Leu Phe
1 5 10 15
Leu Leu Phe His Gly Ser Met Ala Gln Val Leu Gly Gln Val Ser Thr
20 25 30
Trp Gln Ser Ser Arg Gln Gly Gly Ser Arg Asp Cys Ser Phe Asp Arg
35 40 45
Leu Gln Ala Ile Glu Pro Val Thr Gln Val Arg Ser Gln Ala Gly Leu
50 55 60
Thr Glu Tyr Phe Asp Glu Gln Asn Glu Gln Phe Arg Cys Ala Gly Val
65 70 75 80
Phe Val Ile Arg Arg Val Ile Glu Pro Arg Gly Leu Leu Leu Pro Arg
85 90 95
Tyr His Asn Thr Pro Gly Leu Val Tyr Ile Leu Gln Gly Asn Gly Phe
100 105 110
Val Gly Leu Thr Phe Pro Gly Cys Pro Glu Thr Phe Arg Glu Gln Phe
115 120 125
Gln Gln Phe Arg Gln Thr Gln Ser Thr Leu Gly Gln Ser Gln Cys Gln
130 135 140
Ser Gln Lys Leu Gly Asp Val His Gln Arg Val His Gln Phe Thr Gln
145 150 155 160
Gly Asp Val Val Ala Leu Pro Thr Gly Val Ala His Trp Ile Tyr Asn
165 170 175
Gly Gly Asp Ala Pro Val Val Ile Val Tyr Val Phe Asp Val Asn Asn
180 185 190
Asn Ala Asn Gln Leu Glu Pro Arg Gln Lys Glu Phe Leu Leu Gly Gly
195 200 205
Asn Tyr Asn Gly Val Leu Gln Tyr Gly Gln Asn Ile Phe Ser Gly Phe
210 215 220
Asn Ala Gln Leu Leu Ser Gln Ala Phe Gly Ile Asn Glu Gln Thr Ser
225 230 235 240
Gln Arg Ile Gln Asn Gln Asn Asp Gly Arg Gly Asp Ile Ile Arg Val
245 250 255
Asp Asn Gly Leu Gln Phe Leu Lys Pro Val Val Thr Gln Gln Gln Pro
260 265 270
Glu Gln Pro Phe Met Pro Ile Gln His Gln Thr Gly Gln Ser Ser Arg
275 280 285
Asn Gly Leu Glu Glu Asn Phe Cys Ser Leu Glu Pro Arg Gln Asn Ile
290 295 300
Glu Asp Pro Asn Arg Ala Asp Thr Tyr Asn Pro Arg Ala Gly Ser Ile
305 310 315 320
Thr Arg Leu Asn Gly Gln Asn Phe Pro Ile Leu Asn Leu Val Gln Met
325 330 335
Ser Ala Thr Arg Val Asn Leu Gln Lys Asn Ala Ile Leu Ser Pro Phe
340 345 350
Trp Asn Ile Asn Ala His Ser Val Val Tyr Val Ile Gln Gly His Ala
355 360 365
Leu Val Gln Val Val Asn Asn Gln Gly His Asn Val Phe Asn Gly Leu
370 375 380
Leu His Arg Gly Gln Leu Leu Ile Ile Pro Gln Asn Tyr Val Val Leu
385 390 395 400
Lys Lys Ala Glu Ser Glu Gly Tyr Gln Tyr Ile Ala Phe Lys Thr Asn
405 410 415
Ala Asn Ser Met Val Ser His Ile Ala Gly Lys Asn Ser Ile Leu Arg
420 425 430
Ala Leu Pro Val Asp Val Ile Ala Asn Ala Tyr Arg Ile Ser Arg Gln
435 440 445
Glu Ala Gln Asn Leu Lys Asn Asn Arg Gly Glu Glu Thr Gly Val Leu
450 455 460
Thr Pro Asn Phe Ser Gln Ser Thr Cys Gln Ser Tyr Gln Thr Glu Asp
465 470 475 480
Val Gln Ser Leu Arg Pro Met Ser His Trp Ser Glu
485 490
<210> 258
<211> 166
<212> PRT
<213> 水稻
<220>
<221> 各种特征
<222> (120)..(120)
<223> Xaa 可以是任何天然存在的氨基酸
<400> 258
Met Ala Ser Asn Lys Val Val Phe Ser Ala Leu Leu Leu Ile Ile Val
1 5 10 15
Ser Val Leu Ala Ala Thr Ala Thr Met Ala Asp His His Lys Asp Gln
20 25 30
Val Val Tyr Ser Leu Gly Glu Arg Cys Gln Pro Gly Met Gly Tyr Pro
35 40 45
Met Tyr Ser Leu Pro Arg Cys Arg Ala Val Val Lys Arg Gln Cys Val
50 55 60
Gly His Gly Ala Pro Gly Gly Ala Val Asp Glu Gln Leu Arg Gln Asp
65 70 75 80
Cys Cys Arg Gln Leu Ala Ala Val Asp Asp Ser Trp Cys Arg Cys Ser
85 90 95
Ala Leu Asn His Met Val Gly Gly Ile Tyr Arg Glu Leu Gly Ala Thr
100 105 110
Asp Val Gly His Pro Met Ala Xaa Val Phe Pro Gly Cys Arg Arg Gly
115 120 125
Asp Leu Glu Arg Ala Ala Ala Ser Leu Pro Ala Phe Cys Asn Val Asp
130 135 140
Ile Pro Asn Gly Thr Gly Gly Val Cys Tyr Trp Leu Gly Tyr Pro Arg
145 150 155 160
Thr Pro Arg Thr Gly His
165
<210> 259
<211> 165
<212> PRT
<213> 水稻
<400> 259
Met Ala Ser Asn Lys Val Val Phe Ser Ala Leu Leu Leu Ile Ile Val
1 5 10 15
Ser Val Leu Arg Arg Asp Gly Thr Met Ala Asp His His Lys Asp Gln
20 25 30
Val Val Tyr Ser Leu Gly Glu Arg Cys Gln Pro Gly Met Gly Tyr Pro
35 40 45
Met Tyr Ser Leu Pro Arg Cys Arg Ala Val Val Lys Arg Gln Cys Val
50 55 60
Gly His Gly Ala Pro Gly Ala Val Asp Glu Gln Leu Arg Gln Asp Cys
65 70 75 80
Cys Arg Gln Leu Ala Ala Val Asp Asp Ser Trp Cys Arg Cys Ser Ala
85 90 95
Leu Asn His Met Val Gly Gly Ile Tyr Arg Glu Leu Gly Ala Thr Asp
100 105 110
Val Gly His Pro Met Ala Glu Val Phe Pro Gly Cys Arg Arg Gly Asp
115 120 125
Leu Glu Arg Ala Ala Ala Ser Leu Pro Ala Phe Cys Asn Val Asp Ile
130 135 140
Pro Asn Gly Thr Gly Gly Val Cys Tyr Trp Leu Gly Tyr Pro Arg Thr
145 150 155 160
Pro Arg Thr Gly His
165
<210> 260
<211> 157
<212> PRT
<213> 水稻
<400> 260
Met Ala Ser Asn Lys Val Val Ile Ser Ala Leu Leu Val Val Val Val
1 5 10 15
Ser Val Leu Ala Ala Thr Thr Thr Met Ala Asp His His Gln Glu Gln
20 25 30
Val Val Tyr Thr Pro Gly Gln Leu Cys Gln Pro Gly Ile Gly Tyr Pro
35 40 45
Thr Tyr Pro Leu Pro Arg Cys Arg Ala Phe Val Lys Arg Gln Cys Val
50 55 60
Ala Pro Gly Thr Val Asp Glu Gln Val Arg Arg Gly Cys Cys Arg Gln
65 70 75 80
Leu Ala Ala Ile Asp Ser Ser Trp Cys Arg Cys Asp Ala Leu Asn His
85 90 95
Met Leu Arg Ile Ile Tyr Arg Glu Ser Gly Ala Ala Asp Ala Gly His
100 105 110
Pro Met Ala Glu Val Phe Arg Gly Cys Arg Arg Gly Asp Ile Glu Arg
115 120 125
Ala Ala Ala Ser Leu Pro Ala Phe Cys Asn Val Asp Ile Pro Asn Gly
130 135 140
Val Gly Gly Val Cys Tyr Trp Leu Pro Gly Thr Gly Tyr
145 150 155
<210> 261
<211> 495
<212> PRT
<213> 水稻
<400> 261
Met Thr Ile Ser Val Phe Ser Arg Phe Ser Ile Tyr Phe Cys Val Leu
1 5 10 15
Leu Leu Cys Asn Gly Ser Met Ala Gln Leu Phe Asp Pro Ala Thr Asn
20 25 30
Gln Trp Gln Thr His Arg Gln Gly Ser Phe Arg Glu Cys Arg Phe Glu
35 40 45
Arg Leu Gln Ala Phe Glu Pro Leu Gln Asn Val Arg Ser Glu Ala Gly
50 55 60
Val Thr Glu Tyr Phe Asp Glu Thr Asn Glu Leu Phe Gln Cys Thr Gly
65 70 75 80
Thr Phe Val Ile Arg Arg Val Ile Gln Pro Gln Gly Leu Leu Ile Pro
85 90 95
Arg Tyr Ala Asn Thr Pro Gly Met Val Tyr Ile Ile Gln Gly Arg Gly
100 105 110
Ser Met Gly Leu Thr Phe Pro Gly Cys Pro Ala Thr Tyr Gln Gln Gln
115 120 125
Ser Gln Gln Phe Leu Phe Gln Gly Glu Ser Gln Ser Gln Lys Phe Ile
130 135 140
Asp Glu His Gln Lys Ile His Gln Phe Arg Gln Gly Asp Ile Val Val
145 150 155 160
Leu Pro Thr Gly Val Ala His Trp Phe Tyr Asn Asp Gly Asp Thr Pro
165 170 175
Val Val Ala Leu Tyr Val Tyr Asp Ile Asn Asn Ser Ala Asn Gln Leu
180 185 190
Glu Pro Arg His Arg Glu Phe Leu Leu Ala Gly Lys Asn Asn Arg Val
195 200 205
Gln Gln Val Tyr Gly Arg Ser Ile Gln Gln His Ser Gly Gln Asn Ile
210 215 220
Phe Asn Gly Phe Ser Val Glu Pro Leu Ser Glu Ala Leu Asn Ile Asn
225 230 235 240
Thr Val Thr Thr Lys Arg Leu Gln Ser Gln Asn Asp Gln Arg Gly Glu
245 250 255
Ile Ile His Val Lys Asn Gly Leu Gln Leu Leu Lys Pro Thr Leu Thr
260 265 270
Gln Arg Gln Glu Gln Glu Gln Ala Gln Tyr Gln Glu Val Gln Tyr Ser
275 280 285
Glu Lys Pro Gln Thr Ser Ser Arg Trp Asn Gly Leu Glu Glu Asn Leu
290 295 300
Cys Thr Ile Lys Thr Arg Leu Asn Ile Glu Asn Pro Ser Arg Ala Asp
305 310 315 320
Ser Tyr Asp Pro Arg Ala Gly Arg Ile Thr Ser Leu Asp Ser Gln Lys
325 330 335
Phe Pro Ile Leu Asn Ile Ile Gln Met Ser Ala Thr Arg Val Asn Leu
340 345 350
Tyr Gln Asn Ala Ile Leu Thr Pro Phe Trp Asn Val Asn Ala His Ser
355 360 365
Leu Met Tyr Val Ile Arg Gly Arg Ala Arg Val Gln Val Val Ser Asn
370 375 380
Phe Gly Lys Thr Val Phe Asp Gly Val Leu Arg Pro Glu Gln Leu Leu
385 390 395 400
Ile Ile Pro Gln Asn Tyr Val Val Leu Lys Lys Ala Gln His Glu Gly
405 410 415
Cys Gln Tyr Ile Ala Ile Asn Thr Asn Ala Asn Ala Phe Val Ser His
420 425 430
Leu Ala Gly Val Asp Ser Val Phe His Ala Leu Pro Val Asp Val Ile
435 440 445
Ala Asn Ala Tyr Cys Ile Ser Arg Glu Glu Ala Arg Arg Leu Lys Asn
450 455 460
Asn Arg Gly Asp Glu Tyr Gly Pro Phe Pro Pro Arg Leu Gln Gln Gln
465 470 475 480
Ile Tyr Pro Glu Phe Ser Asn Glu Ser Lys Gly Glu Thr Ser Glu
485 490 495
<210> 262
<211> 480
<212> PRT
<213> 水稻
<400> 262
Leu Leu Cys His Gly Ser Met Ala Gln Ile Phe Ser Leu Gly Ile Asn
1 5 10 15
Pro Trp Gln Asn Pro Arg Gln Gly Gly Ser Arg Glu Cys Arg Phe Asp
20 25 30
Arg Leu Gln Ala Phe Glu Pro Leu Arg Lys Val Arg His Glu Ala Gly
35 40 45
Val Thr Glu Tyr Phe Asp Glu Lys Asn Glu Gln Phe Gln Cys Thr Gly
50 55 60
Thr Leu Val Ile Arg Arg Ile Ile Glu Pro Gln Gly Leu Leu Leu Pro
65 70 75 80
Arg Tyr Ser Asn Thr Pro Gly Leu Val Tyr Ile Ile Gln Gly Thr Gly
85 90 95
Val Leu Gly Leu Thr Phe Pro Gly Cys Pro Ala Thr Tyr Gln Lys Gln
100 105 110
Phe Arg His Phe Gly Leu Glu Gly Gly Ser Gln Arg Gln Gly Lys Lys
115 120 125
Leu Arg Asp Glu Asn Gln Lys Ile His Gln Phe Arg Gln Gly Asp Val
130 135 140
Val Ala Leu Pro Ser Gly Ile Pro His Trp Phe Tyr Asn Glu Gly Asp
145 150 155 160
Thr Pro Val Val Ala Leu Phe Val Phe Asp Val Asn Asn Asn Ala Asn
165 170 175
Gln Leu Glu Pro Arg Gln Lys Glu Phe Leu Leu Ala Gly Asn Asn Ile
180 185 190
Glu Gln Gln Val Ser Asn Pro Ser Ile Asn Lys His Ser Gly Gln Asn
195 200 205
Ile Phe Asn Gly Phe Asn Thr Lys Leu Leu Ser Glu Ala Leu Gly Val
210 215 220
Asn Ile Glu Val Thr Arg Arg Leu Gln Ser Gln Asn Asp Arg Arg Gly
225 230 235 240
Asp Ile Ile Arg Val Lys Asn Gly Leu Arg Leu Ile Lys Pro Thr Ile
245 250 255
Thr Gln Gln Gln Glu Gln Thr Gln Asp Gln Tyr Gln Gln Ile Gln Tyr
260 265 270
His Arg Glu Gln Arg Ser Thr Ser Lys Tyr Asn Gly Leu Asp Glu Asn
275 280 285
Phe Cys Ala Ile Arg Ala Arg Leu Asn Ile Glu Asn Pro Asn His Ala
290 295 300
Asp Thr Tyr Asn Pro Arg Ala Gly Arg Ile Thr Asn Leu Asn Ser Gln
305 310 315 320
Lys Phe Ser Ile Leu Asn Leu Val Gln Met Ser Ala Thr Arg Val Asn
325 330 335
Leu Tyr Gln Asn Ala Ile Leu Ser Pro Phe Trp Asn Ile Asn Ala His
340 345 350
Ser Leu Val Tyr Thr Ile Gln Gly Arg Ala Arg Val Gln Val Val Ser
355 360 365
Asn His Gly Lys Ala Val Phe Asn Gly Val Leu Arg Pro Gly Gln Leu
370 375 380
Leu Ile Ile Pro Gln Asn Tyr Val Val Met Lys Lys Ala Glu Leu Glu
385 390 395 400
Gly Phe Gln Phe Ile Ala Phe Lys Thr Asn Pro Asn Ala Met Val Asn
405 410 415
His Ile Ala Gly Lys Asn Ser Val Leu Arg Ala Met Pro Val Asp Val
420 425 430
Ile Ala Asn Ala Tyr Arg Ile Ser Arg Gln Glu Ala Arg Ser Leu Lys
435 440 445
Asn Asn Arg Gly Glu Glu Ile Gly Ala Phe Thr Pro Arg Tyr Gln Gln
450 455 460
Gln Lys Ile His Gln Glu Tyr Ser Asn Pro Asn Glu Ser Glu Thr Gln
465 470 475 480
<210> 263
<211> 518
<212> PRT
<213> 燕麦
<400> 263
Met Ala Thr Thr Arg Phe Pro Ser Leu Leu Phe Tyr Ser Cys Ile Phe
1 5 10 15
Leu Leu Cys Asn Gly Ser Met Ala Gln Leu Phe Gly Gln Ser Phe Thr
20 25 30
Pro Trp Gln Ser Ser Arg Gln Gly Gly Leu Arg Gly Cys Arg Phe Asp
35 40 45
Arg Leu Gln Ala Phe Glu Pro Leu Arg Gln Val Arg Ser Gln Ala Gly
50 55 60
Ile Thr Glu Tyr Phe Asp Glu Gln Asn Glu Gln Phe Arg Cys Ala Gly
65 70 75 80
Val Ser Val Ile Arg Arg Val Ile Glu Pro Gln Gly Leu Leu Leu Pro
85 90 95
Gln Tyr His Asn Ala Pro Gly Leu Val Tyr Ile Leu Gln Gly Arg Gly
100 105 110
Phe Thr Gly Leu Thr Phe Pro Gly Cys Pro Ala Thr Phe Gln Gln Gln
115 120 125
Phe Gln Pro Phe Asp Gln Ala Arg Phe Ala Gln Gly Gln Ser Lys Ser
130 135 140
Gln Asn Leu Lys Asp Glu His Gln Arg Val His His Ile Lys Gln Gly
145 150 155 160
Asp Val Val Ala Leu Pro Ala Gly Ile Val His Trp Cys Tyr Asn Asp
165 170 175
Gly Asp Ala Pro Ile Val Ala Val Tyr Val Phe Asp Val Asn Asn Asn
180 185 190
Ala Asn Gln Leu Glu Pro Arg Gln Lys Glu Phe Leu Leu Ala Gly Asn
195 200 205
Asn Lys Arg Glu Gln Gln Phe Gly Gln Asn Ile Phe Ser Gly Phe Ser
210 215 220
Val Gln Leu Leu Ser Glu Ala Leu Gly Ile Ser Gln Gln Ala Ala Gln
225 230 235 240
Lys Ile Gln Ser Gln Asn Asp Gln Arg Gly Glu Ile Ile Arg Val Ser
245 250 255
Gln Gly Leu Gln Phe Leu Lys Pro Phe Val Ser Gln Gln Gly Pro Val
260 265 270
Glu His Gln Ala Tyr Gln Pro Ile Gln Ser Gln Gln Glu Gln Ser Thr
275 280 285
Gln Tyr Gln Val Gly Gln Ser Pro Gln Tyr Gln Glu Gly Gln Ser Thr
290 295 300
Gln Tyr Gln Ser Gly Gln Ser Trp Asp Gln Ser Phe Asn Gly Leu Glu
305 310 315 320
Glu Asn Phe Cys Ser Leu Glu Ala Arg Gln Asn Ile Glu Asn Pro Lys
325 330 335
Arg Ala Asp Thr Tyr Asn Pro Arg Ala Gly Arg Ile Thr His Leu Asn
340 345 350
Ser Lys Asn Phe Pro Thr Leu Asn Leu Val Gln Met Ser Ala Thr Arg
355 360 365
Val Asn Leu Tyr Gln Asn Ala Ile Leu Ser Pro Tyr Trp Asn Ile Asn
370 375 380
Ala His Ser Val Met His Met Ile Gln Gly Arg Ala Arg Val Gln Val
385 390 395 400
Val Asn Asn His Gly Gln Thr Val Phe Asn Asp Ile Leu Arg Arg Gly
405 410 415
Gln Leu Leu Ile Ile Pro Gln His Tyr Val Val Leu Lys Lys Ala Glu
420 425 430
Arg Glu Gly Cys Gln Tyr Ile Ser Phe Lys Thr Thr Pro Asn Ser Met
435 440 445
Val Ser Tyr Ile Ala Gly Lys Thr Ser Ile Leu Arg Ala Leu Pro Val
450 455 460
Asp Val Leu Ala Asn Ala Tyr Arg Ile Ser Arg Gln Glu Ser Gln Asn
465 470 475 480
Leu Lys Asn Asn Arg Gly Glu Glu Phe Gly Ala Phe Thr Pro Lys Phe
485 490 495
Ala Gln Thr Gly Ser Gln Ser Tyr Gln Asp Glu Gly Glu Ser Ser Ser
500 505 510
Thr Glu Lys Ala Ser Glu
515
<210> 264
<211> 605
<212> PRT
<213> 普通野生稻
<400> 264
Met Ser Ala Leu Thr Thr Ser Gln Leu Ala Thr Ser Ala Thr Gly Phe
1 5 10 15
Gly Ile Ala Asp Arg Ser Ala Pro Ser Ser Leu Leu Arg His Gly Phe
20 25 30
Gln Gly Leu Lys Pro Arg Ser Pro Ala Gly Gly Asp Ala Thr Ser Leu
35 40 45
Ser Val Thr Thr Ser Ala Arg Ala Thr Pro Lys Gln Gln Arg Ser Val
50 55 60
Gln Arg Gly Ser Arg Arg Phe Pro Ser Val Val Val Tyr Ala Thr Gly
65 70 75 80
Ala Gly Met Asn Val Val Phe Val Gly Ala Glu Met Ala Pro Trp Ser
85 90 95
Lys Thr Gly Gly Leu Gly Asp Val Leu Gly Gly Leu Pro Pro Ala Met
100 105 110
Ala Ala Asn Gly His Arg Val Met Val Ile Ser Pro Arg Tyr Asp Gln
115 120 125
Tyr Lys Asp Ala Trp Asp Thr Ser Val Val Ala Glu Ile Lys Val Ala
130 135 140
Asp Arg Tyr Glu Arg Val Arg Phe Phe His Cys Tyr Lys Arg Gly Val
145 150 155 160
Asp Arg Val Phe Val Asp His Pro Ser Phe Leu Glu Lys Val Trp Gly
165 170 175
Lys Thr Gly Glu Lys Ile Tyr Gly Pro Asp Thr Gly Val Asp Tyr Lys
180 185 190
Asp Asn Gln Met Arg Phe Ser Leu Leu Cys Gln Ala Pro Arg Ile Leu
195 200 205
Asn Leu Asn Asn Asn Pro Tyr Phe Lys Gly Thr Tyr Gly Glu Asp Val
210 215 220
Val Phe Val Cys Asn Asp Trp His Thr Gly Pro Leu Ala Ser Tyr Leu
225 230 235 240
Lys Asn Asn Tyr Gln Pro Asn Gly Ile Tyr Arg Asn Ala Lys Val Ala
245 250 255
Phe Cys Ile His Asn Ile Ser Tyr Gln Gly Arg Phe Ala Phe Glu Asp
260 265 270
Tyr Pro Glu Leu Asn Leu Ser Glu Arg Phe Arg Ser Ser Phe Asp Phe
275 280 285
Ile Asp Gly Tyr Asp Thr Pro Val Glu Gly Arg Lys Ile Asn Trp Met
290 295 300
Lys Ala Gly Ile Leu Glu Ala Asp Arg Val Leu Thr Val Ser Pro Tyr
305 310 315 320
Tyr Ala Glu Glu Leu Ile Ser Gly Ile Ala Arg Gly Cys Glu Leu Asp
325 330 335
Asn Ile Met Arg Leu Thr Gly Ile Thr Gly Ile Val Asn Gly Met Asp
340 345 350
Val Ser Glu Trp Asp Pro Ser Lys Asp Lys Tyr Ile Thr Ala Lys Tyr
355 360 365
Asp Ala Thr Thr Ala Ile Glu Ala Lys Ala Leu Asn Lys Glu Ala Leu
370 375 380
Gln Ala Glu Ala Gly Leu Pro Val Asp Arg Lys Ile Pro Leu Ile Ala
385 390 395 400
Phe Ile Gly Arg Leu Glu Glu Gln Lys Gly Pro Asp Val Met Ala Ala
405 410 415
Ala Ile Pro Glu Leu Met Gln Glu Asp Val Gln Ile Val Leu Leu Gly
420 425 430
Thr Gly Lys Lys Lys Phe Glu Lys Leu Leu Lys Ser Met Glu Glu Lys
435 440 445
Tyr Pro Gly Lys Val Arg Ala Val Val Lys Phe Asn Ala Pro Leu Ala
450 455 460
His Leu Ile Met Ala Gly Ala Asp Val Leu Ala Val Pro Ser Arg Phe
465 470 475 480
Glu Pro Cys Gly Leu Ile Gln Leu Gln Gly Met Arg Tyr Gly Thr Pro
485 490 495
Cys Ala Cys Ala Ser Thr Gly Gly Leu Val Asp Thr Val Ile Glu Gly
500 505 510
Lys Thr Gly Phe His Met Gly Arg Leu Ser Val Asp Cys Lys Val Val
515 520 525
Glu Pro Ser Asp Val Lys Lys Val Ala Ala Thr Leu Lys Arg Ala Ile
530 535 540
Lys Val Val Gly Thr Pro Ala Tyr Glu Glu Met Val Arg Asn Cys Met
545 550 555 560
Asn Gln Asp Leu Ser Trp Lys Gly Pro Ala Lys Asn Trp Glu Asn Val
565 570 575
Leu Leu Gly Leu Gly Val Ala Gly Ser Ala Pro Gly Ile Glu Gly Asp
580 585 590
Glu Ile Ala Pro Leu Ala Lys Glu Asn Val Ala Ala Pro
595 600 605
<210> 265
<211> 609
<212> PRT
<213> 药用野生稻
<400> 265
Met Ser Ala Leu Thr Thr Ser Gln Leu Ala Thr Ser Ala Thr Gly Phe
1 5 10 15
Gly Ile Ala Asp Arg Ser Ala Pro Ser Ser Leu Leu Arg His Gly Phe
20 25 30
Gln Gly Leu Lys Pro Arg Ser Pro Ala Gly Gly Asp Ala Ser Ser Leu
35 40 45
Ser Val Thr Thr Ser Ala Arg Ala Thr Pro Lys Gln Gln Arg Ser Val
50 55 60
Gln Arg Gly Ser Arg Arg Phe Pro Ser Val Val Val Tyr Ala Thr Gly
65 70 75 80
Ala Gly Met Asn Val Val Phe Val Gly Ala Glu Met Ala Pro Trp Ser
85 90 95
Lys Thr Gly Gly Leu Gly Asp Val Leu Gly Gly Leu Pro Pro Ala Met
100 105 110
Ala Ala Asn Gly His Arg Val Met Val Ile Ser Pro Arg His Asp Gln
115 120 125
Tyr Lys Asp Ala Trp Asp Thr Ser Val Val Ala Glu Ile Lys Val Ala
130 135 140
Asp Arg Tyr Glu Arg Val Arg Phe Phe His Cys Tyr Lys Arg Gly Val
145 150 155 160
Asp Arg Val Phe Ile Asp His Pro Ser Phe Leu Glu Lys Val Trp Gly
165 170 175
Lys Thr Gly Glu Lys Ile Tyr Gly Pro Asp Thr Gly Val Asp Tyr Lys
180 185 190
Asp Asn Gln Met Arg Phe Ser Leu Leu Cys Gln Ala Ala Leu Glu Ala
195 200 205
Pro Arg Ile Leu Asn Leu Asn Asn Asn Pro Tyr Phe Lys Gly Thr Tyr
210 215 220
Gly Glu Asp Val Val Phe Val Cys Asn Asp Trp His Thr Gly Pro Leu
225 230 235 240
Pro Ser Tyr Leu Lys Asn Asn Tyr Gln Pro Asn Gly Ile Tyr Arg Asn
245 250 255
Ala Lys Val Ala Phe Cys Ile His Asn Ile Ser Tyr Gln Gly Arg Phe
260 265 270
Ala Phe Glu Asp Tyr Pro Glu Leu Asn Leu Ser Glu Arg Phe Arg Ser
275 280 285
Ser Phe Asp Phe Ile Asp Gly Tyr Asp Thr Pro Val Glu Gly Arg Lys
290 295 300
Ile Asn Trp Met Lys Ala Gly Ile Leu Glu Ser Asp Arg Val Leu Thr
305 310 315 320
Val Ser Pro Tyr Tyr Ala Glu Glu Leu Ile Ser Gly Ile Ala Arg Gly
325 330 335
Cys Glu Leu Asp Asn Ile Met Arg Leu Thr Gly Ile Thr Gly Ile Val
340 345 350
Asn Gly Met Asp Val Ser Glu Trp Asp Pro Ser Lys Asp Lys Tyr Ile
355 360 365
Ala Ala Lys Tyr Asp Ala Thr Thr Ala Ile Glu Ala Lys Ala Leu Asn
370 375 380
Lys Glu Ala Leu Gln Ala Glu Ala Gly Leu Pro Val Asp Arg Lys Ile
385 390 395 400
Pro Leu Ile Ala Phe Ile Gly Arg Leu Glu Glu Gln Lys Gly Pro Asp
405 410 415
Val Met Ala Ala Ala Ile Pro Glu Leu Met Gln Glu Asn Val Gln Ile
420 425 430
Val Leu Leu Gly Thr Gly Lys Lys Lys Phe Glu Lys Leu Leu Lys Ser
435 440 445
Met Glu Glu Lys Tyr Pro Gly Lys Val Arg Ala Val Val Lys Phe Asn
450 455 460
Ala Pro Leu Ala His Leu Ile Met Ala Gly Ala Asp Val Leu Ala Val
465 470 475 480
Pro Ser Arg Phe Glu Pro Cys Gly Leu Ile Gln Leu Gln Gly Met Arg
485 490 495
Tyr Gly Thr Pro Cys Ala Cys Ala Ser Thr Gly Gly Leu Val Asp Thr
500 505 510
Val Ile Glu Gly Lys Thr Gly Phe His Met Gly Arg Leu Ser Val Asp
515 520 525
Cys Lys Val Val Glu Pro Ser Asp Val Gln Lys Val Ala Thr Thr Leu
530 535 540
Lys Arg Ala Ile Lys Ile Val Gly Thr Pro Ala Tyr Asn Glu Met Val
545 550 555 560
Arg Asn Cys Met Asn Gln Asp Leu Ser Trp Lys Gly Pro Ala Lys Asn
565 570 575
Trp Glu Asn Val Leu Leu Gly Leu Gly Val Ala Gly Ser Ala Pro Gly
580 585 590
Val Glu Gly Glu Glu Ile Ala Pro Leu Ala Lys Glu Asn Val Ala Ala
595 600 605
Pro
<210> 266
<211> 603
<212> PRT
<213> 青稞
<400> 266
Met Ala Ala Leu Ala Thr Ser Gln Leu Ala Thr Ser Gly Thr Val Leu
1 5 10 15
Gly Val Thr Asp Arg Phe Arg Arg Pro Gly Phe Gln Gly Leu Arg Pro
20 25 30
Arg Asn Pro Ala Asp Ala Ala Leu Gly Met Arg Thr Ile Gly Ala Ser
35 40 45
Ala Ala Pro Lys Gln Ser Arg Lys Ala His Arg Gly Ser Arg Arg Cys
50 55 60
Leu Ser Val Val Val Arg Ala Thr Gly Ser Gly Met Asn Leu Val Phe
65 70 75 80
Val Gly Ala Glu Met Ala Pro Trp Ser Lys Thr Gly Gly Leu Gly Asp
85 90 95
Val Leu Gly Gly Leu Pro Pro Ala Met Ala Ala Asn Gly His Arg Val
100 105 110
Met Val Val Ser Pro Arg Tyr Asp Gln Tyr Lys Asp Ala Trp Asp Thr
115 120 125
Ser Val Ile Ser Glu Ile Lys Val Ala Asp Glu Tyr Glu Arg Val Arg
130 135 140
Phe Phe His Cys Tyr Lys Arg Gly Val Asp Arg Val Phe Ile Asp His
145 150 155 160
Pro Trp Phe Leu Glu Lys Val Arg Gly Lys Thr Lys Glu Lys Ile Tyr
165 170 175
Gly Pro Asp Ala Gly Thr Asp Tyr Glu Asp Asn Gln Gln Arg Phe Ser
180 185 190
Leu Leu Cys Gln Ala Ala Leu Glu Ala Pro Arg Ile Leu Asn Leu Asn
195 200 205
Asn Asn Pro Tyr Phe Ser Gly Pro Tyr Gly Glu Asp Val Val Phe Val
210 215 220
Cys Asn Asp Trp His Thr Gly Leu Leu Ala Cys Tyr Leu Lys Ser Asn
225 230 235 240
Tyr Gln Ser Asn Gly Ile Tyr Arg Thr Ala Lys Val Ala Phe Cys Ile
245 250 255
His Asn Ile Ser Tyr Gln Gly Arg Phe Ser Phe Asp Asp Phe Ala Gln
260 265 270
Leu Asn Leu Pro Asp Arg Phe Lys Ser Ser Phe Asp Phe Ile Asp Gly
275 280 285
Tyr Asp Lys Pro Val Glu Gly Arg Lys Ile Asn Trp Met Lys Ala Gly
290 295 300
Ile Leu Gln Ala Asp Lys Val Leu Thr Val Ser Pro Tyr Tyr Ala Glu
305 310 315 320
Glu Leu Ile Ser Asp Glu Ala Arg Gly Cys Glu Leu Asp Asn Ile Met
325 330 335
Arg Leu Thr Gly Ile Thr Gly Ile Val Asn Gly Met Asp Val Ser Glu
340 345 350
Trp Asp Pro Thr Lys Asp Lys Phe Leu Ala Val Asn Tyr Asp Ile Thr
355 360 365
Thr Ala Leu Glu Ala Lys Ala Leu Asn Lys Glu Ala Leu Gln Ala Glu
370 375 380
Val Gly Leu Pro Val Asp Arg Lys Val Pro Leu Val Ala Phe Ile Gly
385 390 395 400
Arg Leu Glu Glu Gln Lys Gly Pro Asp Val Met Ile Ala Ala Ile Pro
405 410 415
Glu Ile Leu Lys Glu Glu Asp Val Gln Ile Ile Leu Leu Gly Thr Gly
420 425 430
Lys Lys Lys Phe Glu Lys Leu Leu Lys Ser Met Glu Glu Lys Phe Pro
435 440 445
Gly Lys Val Arg Ala Val Val Arg Phe Asn Ala Pro Leu Ala His Gln
450 455 460
Met Met Ala Gly Ala Asp Leu Leu Ala Val Thr Ser Arg Phe Glu Pro
465 470 475 480
Cys Gly Leu Ile Gln Leu Gln Gly Met Arg Tyr Gly Thr Pro Cys Val
485 490 495
Cys Ala Ser Thr Gly Gly Leu Val Asp Thr Ile Val Glu Gly Lys Thr
500 505 510
Gly Phe His Met Gly Arg Leu Ser Val Asp Cys Asn Val Val Glu Pro
515 520 525
Ala Asp Val Lys Lys Val Ala Thr Thr Leu Lys Arg Ala Val Lys Val
530 535 540
Val Gly Thr Pro Ala Tyr Gln Glu Met Val Lys Asn Cys Met Ile Gln
545 550 555 560
Asp Leu Ser Trp Lys Gly Pro Ala Lys Asn Trp Glu Asp Val Leu Leu
565 570 575
Glu Leu Gly Val Glu Gly Ser Glu Pro Gly Ile Val Gly Glu Glu Ile
580 585 590
Ala Pro Leu Ala Met Glu Asn Val Ala Ala Pro
595 600
<210> 267
<211> 336
<212> PRT
<213> 金黄色酿脓葡萄球菌
<400> 267
Met Lys Gly Lys Phe Leu Lys Val Ser Ser Leu Phe Val Ala Thr Leu
1 5 10 15
Thr Thr Ala Thr Leu Val Ser Ser Pro Ala Ala Asn Ala Leu Ser Ser
20 25 30
Lys Ala Met Asp Asn His Pro Gln Gln Ser Gln Ser Ser Lys Gln Gln
35 40 45
Thr Pro Lys Ile Gln Lys Gly Gly Asn Leu Lys Pro Leu Glu Gln Arg
50 55 60
Glu His Ala Asn Val Ile Leu Pro Asn Asn Asp Arg His Gln Ile Thr
65 70 75 80
Asp Thr Thr Asn Gly His Tyr Ala Pro Val Thr Tyr Ile Gln Val Glu
85 90 95
Ala Pro Thr Gly Thr Phe Ile Ala Ser Gly Val Val Val Gly Lys Asp
100 105 110
Thr Leu Leu Thr Asn Lys His Val Val Asp Ala Thr His Gly Asp Pro
115 120 125
His Ala Leu Lys Ala Phe Pro Ser Ala Ile Asn Gln Asp Asn Tyr Pro
130 135 140
Asn Gly Gly Phe Thr Ala Glu Gln Ile Thr Lys Tyr Ser Gly Glu Gly
145 150 155 160
Asp Leu Ala Ile Val Lys Phe Ser Pro Asn Glu Gln Asn Lys His Ile
165 170 175
Gly Glu Val Val Lys Pro Ala Thr Met Ser Asn Asn Ala Glu Thr Gln
180 185 190
Val Asn Gln Asn Ile Thr Val Thr Gly Tyr Pro Gly Asp Lys Pro Val
195 200 205
Ala Thr Met Trp Glu Ser Lys Gly Lys Ile Thr Tyr Leu Lys Gly Glu
210 215 220
Ala Met Gln Tyr Asp Leu Ser Thr Thr Gly Gly Asn Ser Gly Ser Pro
225 230 235 240
Val Phe Asn Glu Lys Asn Glu Val Ile Gly Ile His Trp Gly Gly Val
245 250 255
Pro Asn Glu Phe Asn Gly Ala Val Phe Ile Asn Glu Asn Val Arg Asn
260 265 270
Phe Leu Lys Gln Asn Ile Glu Asp Ile His Phe Ala Asn Asp Asp Gln
275 280 285
Pro Asn Asn Pro Asp Asn Pro Asp Asn Pro Asn Asn Pro Asp Asn Pro
290 295 300
Asn Asn Pro Asp Glu Pro Asn Asn Pro Asp Asn Pro Asn Asn Pro Asp
305 310 315 320
Asn Pro Asp Asn Gly Asp Asn Asn Asn Ser Asp Asn Pro Asp Ala Ala
325 330 335
<210> 268
<211> 14
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 268
Arg Gly Pro Gln Gln Tyr Ala Glu Trp Gln Ile Asn Glu Arg
1 5 10
<210> 269
<211> 14
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 269
Arg Gly Pro Gln Gln Tyr Ala Glu Trp Gln Ile Asn Asp Lys
1 5 10
<210> 270
<211> 14
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 270
Arg Gly Pro Gln Gln Phe Ala Glu Trp Gln Ile Asn Glu Lys
1 5 10
<210> 271
<211> 14
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 271
Lys Gly Pro Gln Gln Tyr Ala Glu Trp Gln Ile Asn Glu Lys
1 5 10
<210> 272
<211> 14
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 272
Arg Gly Pro Glu Gln Tyr Ala Glu Trp Gln Ile Asn Glu Lys
1 5 10
<210> 273
<211> 14
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 273
Arg Gly Pro Gln Glu Tyr Ala Glu Trp Gln Ile Asn Glu Lys
1 5 10
<210> 274
<211> 14
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 274
Arg Gly Pro Gln Gln Tyr Ala Asp Trp Gln Ile Asn Glu Lys
1 5 10
<210> 275
<211> 14
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 275
Arg Gly Pro Gln Gln Tyr Ala Glu Tyr Gln Ile Asn Glu Lys
1 5 10
<210> 276
<211> 14
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 276
Lys Gly Pro Glu Gln Tyr Ala Glu Trp Gln Ile Asn Glu Lys
1 5 10
<210> 277
<211> 14
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 277
Lys Gly Pro Gln Glu Tyr Ala Glu Trp Gln Ile Asn Glu Lys
1 5 10
<210> 278
<211> 14
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 278
Lys Gly Pro Gln Gln Phe Ala Glu Trp Gln Ile Asn Glu Lys
1 5 10
<210> 279
<211> 14
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 279
Arg Gly Pro Glu Gln Phe Ala Glu Trp Gln Ile Asn Glu Lys
1 5 10
<210> 280
<211> 14
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 280
Lys Gly Pro Gln Gln Tyr Ala Glu Trp Gln Ile Asn Glu Arg
1 5 10
<210> 281
<211> 14
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 281
Arg Gly Pro Gln Gln Tyr Ala Glu Trp Gln Ile Asn Asp Arg
1 5 10
<210> 282
<211> 14
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 282
Arg Gly Pro Gln Gln Tyr Ala Asp Trp Gln Ile Asn Asp Lys
1 5 10
<210> 283
<211> 14
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 283
Arg Gly Pro Gln Gln Phe Ala Glu Trp Gln Ile Asn Glu Arg
1 5 10
<210> 284
<211> 14
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 284
Arg Gly Pro Gln Gln Tyr Ala Glu Trp Gln Val Asn Glu Lys
1 5 10
<210> 285
<211> 14
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 285
Arg Gly Pro Gln Gln Phe Ala Glu Trp Gln Ile Asn Glu Lys
1 5 10
<210> 286
<211> 14
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 286
Lys Gly Pro Gln Gln Phe Ala Glu Trp Gln Ile Asn Glu Arg
1 5 10
<210> 287
<211> 14
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 287
Lys Gly Pro Gln Gln Phe Ala Glu Trp Gln Val Asn Glu Lys
1 5 10
<210> 288
<211> 14
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 288
Arg Gly Pro Gln Gln Phe Ala Glu Trp Gln Val Asn Asp Lys
1 5 10
<210> 289
<211> 14
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 289
Arg Gly Pro Gln Gln Tyr Ala Asp Trp Gln Ile Asn Asp Arg
1 5 10
<210> 290
<211> 14
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 290
Lys Gly Pro Gln Gln Tyr Ala Asp Trp Gln Ile Asn Asp Lys
1 5 10
<210> 291
<211> 14
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 291
Arg Gly Pro Gln Gln Phe Ala Asp Tyr Gln Ile Asn Glu Lys
1 5 10
<210> 292
<211> 14
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 292
Arg Gly Pro Gln Gln Tyr Ala Arg Trp Gln Ile Asn Glu Lys
1 5 10
<210> 293
<211> 14
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 293
Arg Gly Pro Gln Gln Tyr Ala Glu Trp Gln Ile Asn Glu Glu
1 5 10
<210> 294
<211> 14
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 294
His Gly Pro Gln Gln Tyr Ala Glu Trp Gln Ile Asn Glu Lys
1 5 10
<210> 295
<211> 14
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 295
Arg Gly Pro Tyr Gln Tyr Ala Glu Trp Gln Ile Asn Glu Lys
1 5 10
<210> 296
<211> 14
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 296
Arg Gly Pro Gln Gln Tyr Met Glu Trp Gln Ile Asn Glu Lys
1 5 10
<210> 297
<211> 14
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 297
Arg Gly Pro Gln Gln Tyr Ala Glu Trp Cys Ile Asn Glu Lys
1 5 10
<210> 298
<211> 14
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 298
Arg Gly Pro Gln Pro Tyr Ala Glu Trp Gln Ile Asn Glu Lys
1 5 10
<210> 299
<211> 14
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 299
Arg Gly Gly Gln Gln Tyr Ala Glu Trp Gln Ile Asn Glu Asp
1 5 10
<210> 300
<211> 14
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 300
Arg Gly Pro Gln Gln Tyr Ala Arg Trp Lys Ile Asn Glu Lys
1 5 10
<210> 301
<211> 14
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 301
Arg Gly Gly Gln Gln Tyr Ala Glu Thr Gln Ile Asn Glu Lys
1 5 10
<210> 302
<211> 14
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 302
Arg Gly Pro Leu Gln Tyr Ala Glu Trp Gln Asn Asn Glu Lys
1 5 10
<210> 303
<211> 14
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 303
Glu Gly Pro Gln Gln Tyr Ala Glu Trp Gln Ile Asn Glu Asp
1 5 10
<210> 304
<211> 14
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 304
Arg Gly Pro Gln Gln Tyr Ala Glu Trp Gln Ile Asn Leu Leu
1 5 10
<210> 305
<211> 14
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 305
Arg Gly Pro Gln Gln Gly Gly Glu Trp Gln Ile Asn Glu Lys
1 5 10
<210> 306
<211> 14
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 306
Arg Gly Pro Gln Gln Tyr Ala Glu Trp Gln Ile Gly Gly Gly
1 5 10
<210> 307
<211> 14
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 307
Arg Gly Pro Gln Gln Lys Tyr Glu Trp Gln Ile Asn Glu Lys
1 5 10
<210> 308
<211> 14
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 308
Arg Gly Pro Gln Ala Gln Tyr Glu Trp Gln Ile Asn Glu Lys
1 5 10
<210> 309
<211> 14
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 309
Arg Pro His Gln Gln Tyr Ala Glu Trp Gln Ile Asn Glu Lys
1 5 10
<210> 310
<211> 14
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 310
Arg Gly Pro Gln His His His Glu Trp Gln Ile Asn Glu Lys
1 5 10
<210> 311
<211> 14
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 311
Arg Gly Pro Pro Gln Tyr Ala Pro Pro Gln Ile Asn Glu Lys
1 5 10
<210> 312
<211> 14
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 312
Arg Gly Pro Gln Cys Tyr Tyr Glu Trp Cys Ile Asn Glu Lys
1 5 10
<210> 313
<211> 14
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 313
Arg Gly Pro Thr Gln Tyr Ala Glu Gly Gln Ile Asn Glu Gly
1 5 10
<210> 314
<211> 15
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 314
Arg Gly Pro Gln Gln Tyr Ala Glu Trp Gln Ile Asn Glu Lys Gly
1 5 10 15
<210> 315
<211> 15
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 315
Arg Gly Pro Gln Gln Tyr Ala Glu Trp Gln Ile Asn Glu Lys Tyr
1 5 10 15
<210> 316
<211> 16
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 316
Arg Gly Pro Gln Gln Tyr Ala Phe Thr Glu Trp Gln Ile Asn Glu Lys
1 5 10 15
<210> 317
<211> 17
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 317
Arg Gly Pro Gln Ser Gln Tyr Ala Glu Trp Gln Ile Asn Glu Lys Pro
1 5 10 15
Met
<210> 318
<211> 16
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 318
Arg Gly Pro Gln Gln Tyr Ala Glu Trp Gln Ile Asn Glu Lys Lys Lys
1 5 10 15
<210> 319
<211> 17
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 319
Arg Arg Arg Arg Gly Pro Gln Gln Tyr Ala Glu Trp Gln Ile Asn Glu
1 5 10 15
Lys
<210> 320
<211> 13
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 320
Arg Gly Pro Gln Gln Tyr Ala Glu Trp Gln Ile Asn Glu
1 5 10
<210> 321
<211> 12
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 321
Arg Gly Pro Gln Gln Tyr Ala Glu Trp Gln Ile Asn
1 5 10
<210> 322
<211> 11
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 322
Arg Gly Pro Gln Gln Tyr Ala Glu Trp Gln Ile
1 5 10
<210> 323
<211> 13
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 323
Gly Pro Gln Gln Tyr Ala Glu Trp Gln Ile Asn Glu Lys
1 5 10
<210> 324
<211> 12
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 324
Pro Gln Gln Tyr Ala Glu Trp Gln Ile Asn Glu Lys
1 5 10
<210> 325
<211> 11
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 325
Gln Gln Tyr Ala Glu Trp Gln Ile Asn Glu Lys
1 5 10
<210> 326
<211> 8
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 326
Gln Gln Tyr Ala Glu Trp Gln Ile
1 5
<210> 327
<211> 11
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 327
Pro Gln Gln Tyr Ala Glu Trp Gln Ile Asn Glu
1 5 10
<210> 328
<211> 10
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 328
Pro Gln Gln Tyr Ala Glu Trp Gln Ile Asn
1 5 10
<210> 329
<211> 7
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 329
Arg Gly Pro Gln Gln Tyr Ala
1 5
<210> 330
<211> 7
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 330
Glu Trp Gln Ile Asn Glu Lys
1 5
<210> 331
<211> 7
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 331
Glu Trp Gln Ile Asn Glu Lys
1 5
<210> 332
<211> 7
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 332
Phe Leu Pro Gln His Thr Asp
1 5
<210> 333
<211> 13
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 333
Gly Pro Gln Gln Tyr Ala Glu Trp Gln Ile Asn Glu Lys
1 5 10
<210> 334
<211> 12
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 334
Pro Gly Gln Leu Gln Ser Phe Leu Leu Ser Gly Asn
1 5 10
<210> 335
<211> 22
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 335
Pro Gly Gln Leu Gln Ser Phe Leu Leu Ser Gly Asn Gln Asn Gln Gln
1 5 10 15
Asn Tyr Leu Ser Gly Phe
20
<210> 336
<211> 8
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 336
Pro Gln Gln Tyr Ala Glu Trp Gln
1 5
<210> 337
<211> 22
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 337
Gln Leu Gln Ser Phe Leu Leu Ser Gly Asn Gln Asn Gln Gln Asn Tyr
1 5 10 15
Leu Ser Gly Phe Ser Lys
20
<210> 338
<211> 12
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 338
Gln Asn Gln Gln Asn Tyr Leu Ser Gly Phe Ser Lys
1 5 10
<210> 339
<211> 12
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 339
Gln Ser Phe Leu Leu Ser Gly Asn Gln Asn Gln Gln
1 5 10
<210> 340
<211> 9
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 340
Gln Ser Phe Leu Leu Ser Gly Asn Gln
1 5
<210> 341
<211> 7
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 341
Arg Gly Pro Gln Gln Tyr Ala
1 5
<210> 342
<211> 8
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 342
Asp Ala Leu Glu Pro Asp Asn Arg
1 5
<210> 343
<211> 17
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 343
Ser Glu Glu Gly Tyr Tyr Gly Glu Gln Gln Gln Gln Pro Gly Met Thr
1 5 10 15
Arg
<210> 344
<211> 14
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 344
Gly Tyr Tyr Gly Glu Gln Gln Gln Gln Pro Gly Met Thr Arg
1 5 10
<210> 345
<211> 11
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 345
Ile Asp Gly Tyr Asp Thr Pro Val Glu Gly Arg
1 5 10
<210> 346
<211> 9
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 346
Asn Gly Val Leu Arg Pro Gly Gln Leu
1 5
<210> 347
<211> 9
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 347
Arg His Gly Glu Trp Gly Pro Ser Tyr
1 5
<210> 348
<211> 4
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 348
Phe Trp Met Ala
1
<210> 349
<211> 12
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 349
Thr Val Phe Asp Gly Val Leu Arg Pro Gly Gln Leu
1 5 10
<210> 350
<211> 16
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 350
Arg Leu Gln Ser Gln Asn Asp Gln Arg Gly Glu Ile Ile His Val Lys
1 5 10 15
<210> 351
<211> 16
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 351
His Gly Pro Val Glu Met Pro Tyr Thr Leu Leu Tyr Pro Ser Ser Lys
1 5 10 15
<210> 352
<211> 9
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 352
Leu Asp Ala Leu Glu Pro Asp Asn Arg
1 5
<210> 353
<211> 186
<212> PRT
<213> 水稻
<400> 353
Met Ala Ser Lys Val Val Phe Phe Ala Ala Ala Leu Met Ala Ala Met
1 5 10 15
Val Ala Ile Ser Gly Ala Gln Leu Ser Glu Ser Glu Met Arg Phe Arg
20 25 30
Asp Arg Gln Cys Gln Arg Glu Val Gln Asp Ser Pro Leu Asp Ala Cys
35 40 45
Arg Gln Val Leu Asp Arg Gln Leu Thr Gly Arg Glu Arg Phe Gln Pro
50 55 60
Met Phe Arg Arg Pro Gly Ala Leu Gly Leu Arg Met Gln Cys Cys Gln
65 70 75 80
Gln Leu Gln Asp Val Ser Arg Glu Cys Arg Cys Ala Ala Ile Arg Arg
85 90 95
Met Val Arg Ser Tyr Glu Glu Ser Met Pro Met Pro Leu Glu Gln Gly
100 105 110
Trp Ser Ser Ser Ser Ser Glu Tyr Tyr Gly Gly Glu Gly Ser Ser Ser
115 120 125
Glu Gln Gly Tyr Tyr Gly Glu Gly Ser Ser Glu Glu Gly Tyr Tyr Gly
130 135 140
Glu Gln Gln Gln Gln Pro Gly Met Thr Arg Val Arg Leu Thr Arg Ala
145 150 155 160
Arg Gln Tyr Ala Ala Gln Leu Pro Ser Met Cys Arg Val Glu Pro Gln
165 170 175
Gln Cys Ser Ile Phe Ala Ala Gly Gln Tyr
180 185
<210> 354
<211> 517
<212> PRT
<213> 豌豆
<400> 354
Met Ala Lys Leu Leu Ala Leu Ser Leu Ser Phe Cys Phe Leu Leu Leu
1 5 10 15
Gly Gly Cys Phe Ala Leu Arg Glu Gln Pro Gln Gln Asn Glu Cys Gln
20 25 30
Leu Glu Arg Leu Asp Ala Leu Glu Pro Asp Asn Arg Ile Glu Ser Glu
35 40 45
Gly Gly Leu Ile Glu Thr Trp Asn Pro Asn Asn Lys Gln Phe Arg Cys
50 55 60
Ala Gly Val Ala Leu Ser Arg Ala Thr Leu Gln Arg Asn Ala Leu Arg
65 70 75 80
Arg Pro Tyr Tyr Ser Asn Ala Pro Gln Glu Ile Phe Ile Gln Gln Gly
85 90 95
Asn Gly Tyr Phe Gly Met Val Phe Pro Gly Cys Pro Glu Thr Phe Glu
100 105 110
Glu Pro Gln Glu Ser Glu Gln Gly Glu Gly Arg Arg Tyr Arg Asp Arg
115 120 125
His Gln Lys Val Asn Arg Phe Arg Glu Gly Asp Ile Ile Ala Val Pro
130 135 140
Thr Gly Ile Val Phe Trp Met Tyr Asn Asp Gln Asp Thr Pro Val Ile
145 150 155 160
Ala Val Ser Leu Thr Asp Ile Arg Ser Ser Asn Asn Gln Leu Asp Gln
165 170 175
Met Pro Arg Arg Phe Tyr Leu Ala Gly Asn His Glu Gln Glu Phe Leu
180 185 190
Gln Tyr Gln His Gln Gln Gly Gly Lys Gln Glu Gln Glu Asn Glu Gly
195 200 205
Asn Asn Ile Phe Ser Gly Phe Lys Arg Asp Tyr Leu Glu Asp Ala Phe
210 215 220
Asn Val Asn Arg His Ile Val Asp Arg Leu Gln Gly Arg Asn Glu Asp
225 230 235 240
Glu Glu Lys Gly Ala Ile Val Lys Val Lys Gly Gly Leu Ser Ile Ile
245 250 255
Ser Pro Pro Glu Lys Gln Ala Arg His Gln Arg Gly Ser Arg Gln Glu
260 265 270
Glu Asp Glu Asp Glu Glu Lys Gln Pro Arg His Gln Arg Gly Ser Arg
275 280 285
Gln Glu Glu Glu Glu Asp Glu Asp Glu Glu Arg Gln Pro Arg His Gln
290 295 300
Arg Arg Arg Gly Glu Glu Glu Glu Glu Asp Lys Lys Glu Arg Gly Gly
305 310 315 320
Ser Gln Lys Gly Lys Ser Arg Arg Gln Gly Asp Asn Gly Leu Glu Glu
325 330 335
Thr Val Cys Thr Ala Lys Leu Arg Leu Asn Ile Gly Pro Ser Ser Ser
340 345 350
Pro Asp Ile Tyr Asn Pro Glu Ala Gly Arg Ile Lys Thr Val Thr Ser
355 360 365
Leu Asp Leu Pro Val Leu Arg Trp Leu Lys Leu Ser Ala Glu His Gly
370 375 380
Ser Leu His Lys Asn Ala Met Phe Val Pro His Tyr Asn Leu Asn Ala
385 390 395 400
Asn Ser Ile Ile Tyr Ala Leu Lys Gly Arg Ala Arg Leu Gln Val Val
405 410 415
Asn Cys Asn Gly Asn Thr Val Phe Asp Gly Glu Leu Glu Ala Gly Arg
420 425 430
Ala Leu Thr Val Pro Gln Asn Tyr Ala Val Ala Ala Lys Ser Leu Ser
435 440 445
Asp Arg Phe Ser Tyr Val Ala Phe Lys Thr Asn Asp Arg Ala Gly Ile
450 455 460
Ala Arg Leu Ala Gly Thr Ser Ser Val Ile Asn Asn Leu Pro Leu Asp
465 470 475 480
Val Val Ala Ala Thr Phe Asn Leu Gln Arg Asn Glu Ala Arg Gln Leu
485 490 495
Lys Ser Asn Asn Pro Phe Lys Phe Leu Val Pro Ala Arg Glu Ser Glu
500 505 510
Asn Arg Ala Ser Ala
515
<210> 355
<211> 861
<212> PRT
<213> 豌豆
<400> 355
Met Phe Ser Gly Val Thr Gly Ile Leu Asn Arg Gly His Lys Ile Lys
1 5 10 15
Gly Thr Val Val Leu Met Arg Lys Asn Val Leu Asp Ile Asn Ser Leu
20 25 30
Thr Thr Val Gly Gly Val Ile Gly Gln Gly Phe Asp Ile Leu Gly Ser
35 40 45
Thr Val Asp Asn Leu Thr Ala Phe Leu Gly Arg Ser Val Ser Leu Gln
50 55 60
Leu Ile Ser Ala Thr Lys Pro Asp Ala Thr Gly Lys Gly Lys Leu Gly
65 70 75 80
Lys Ala Thr Phe Leu Glu Gly Ile Ile Ser Ser Leu Pro Thr Leu Gly
85 90 95
Ala Gly Gln Ser Ala Phe Lys Ile His Phe Glu Trp Asp Asp Asp Met
100 105 110
Gly Ile Pro Gly Ala Phe Tyr Ile Lys Asn Phe Met Gln Thr Glu Phe
115 120 125
Phe Leu Val Ser Leu Thr Leu Asp Asp Ile Pro Asn His Gly Ser Ile
130 135 140
Tyr Phe Val Cys Asn Ser Trp Ile Tyr Asn Ala Lys His His Lys Ile
145 150 155 160
Asp Arg Ile Phe Phe Ala Asn Gln Thr Tyr Leu Pro Ser Glu Thr Pro
165 170 175
Ala Pro Leu Val His Tyr Arg Glu Glu Glu Leu Asn Asn Leu Arg Gly
180 185 190
Asp Gly Thr Gly Glu Arg Lys Glu Trp Glu Arg Ile Tyr Asp Tyr Asp
195 200 205
Val Tyr Asn Asp Leu Gly Asn Pro Asp Ser Gly Glu Asn His Ala Arg
210 215 220
Pro Val Leu Gly Gly Ser Glu Thr Tyr Pro Tyr Pro Arg Arg Gly Arg
225 230 235 240
Thr Gly Arg Lys Pro Thr Arg Lys Asp Pro Asn Ser Glu Ser Arg Ser
245 250 255
Asp Tyr Val Tyr Leu Pro Arg Asp Glu Ala Phe Gly His Leu Lys Ser
260 265 270
Ser Asp Phe Leu Thr Tyr Gly Leu Lys Ala Val Ser Gln Asn Val Val
275 280 285
Pro Ala Leu Glu Ser Val Phe Phe Asp Leu Asn Phe Thr Pro Asn Glu
290 295 300
Phe Asp Ser Phe Asp Glu Val His Gly Leu Tyr Glu Gly Gly Ile Lys
305 310 315 320
Leu Pro Thr Asn Ile Leu Ser Gln Ile Ser Pro Leu Pro Val Leu Lys
325 330 335
Glu Ile Phe Arg Thr Asp Gly Glu Asn Thr Leu Lys Tyr Pro Pro Pro
340 345 350
Lys Val Ile Gln Val Ser Arg Ser Gly Trp Met Thr Asp Glu Glu Phe
355 360 365
Ala Arg Glu Met Leu Ala Gly Val Asn Pro Asn Val Ile Cys Cys Leu
370 375 380
Gln Glu Phe Pro Pro Arg Ser Lys Leu Asp Ser Gln Ile Tyr Gly Asp
385 390 395 400
His Thr Ser Lys Ile Ser Lys Glu His Leu Glu Pro Asn Leu Glu Gly
405 410 415
Leu Thr Val Glu Glu Ala Ile Gln Asn Lys Lys Leu Phe Leu Leu Asp
420 425 430
His His Asp Ser Ile Met Pro Tyr Leu Arg Arg Ile Asn Ser Thr Ser
435 440 445
Thr Lys Ala Tyr Ala Thr Arg Thr Ile Leu Phe Leu Asn Asn Asn Gln
450 455 460
Asn Leu Lys Pro Leu Ala Ile Glu Leu Ser Leu Pro His Pro Gln Gly
465 470 475 480
Asp Glu His Gly Ala Val Ser Tyr Val Tyr Gln Pro Ala Leu Glu Gly
485 490 495
Val Glu Ser Ser Ile Trp Leu Leu Ala Lys Ala Tyr Val Ile Val Asn
500 505 510
Asp Ser Cys Tyr His Gln Leu Val Ser His Trp Leu Asn Thr His Ala
515 520 525
Val Val Glu Pro Phe Val Ile Ala Thr Asn Arg His Leu Ser Cys Leu
530 535 540
His Pro Ile Tyr Lys Leu Leu Tyr Pro His Tyr Arg Asp Thr Met Asn
545 550 555 560
Ile Asn Ser Leu Ala Arg Leu Ser Leu Val Asn Asp Gly Gly Ile Ile
565 570 575
Glu Lys Thr Phe Leu Trp Gly Arg Tyr Ser Met Glu Met Ser Ser Lys
580 585 590
Val Tyr Lys Asn Trp Val Phe Thr Glu Gln Ala Leu Pro Ala Asp Leu
595 600 605
Ile Lys Arg Gly Met Ala Ile Glu Asp Pro Ser Ser Pro Cys Gly Val
610 615 620
Lys Leu Val Val Glu Asp Tyr Pro Tyr Ala Val Asp Gly Leu Glu Ile
625 630 635 640
Trp Ala Ile Ile Lys Thr Trp Val Gln Asp Tyr Val Ser Leu Tyr Tyr
645 650 655
Thr Ser Asp Glu Lys Leu Arg Gln Asp Ser Glu Leu Gln Ala Trp Trp
660 665 670
Lys Glu Leu Val Glu Val Gly His Gly Asp Lys Lys Asn Glu Pro Trp
675 680 685
Trp Pro Lys Met Gln Thr Arg Glu Asp Leu Ile Glu Val Cys Ser Ile
690 695 700
Val Ile Trp Thr Ala Ser Ala Leu His Ala Ala Val Asn Phe Gly Gln
705 710 715 720
Tyr Ser Tyr Gly Gly Leu Ile Leu Asn Arg Pro Thr Leu Ser Arg Arg
725 730 735
Phe Met Pro Glu Lys Gly Ser Ala Glu Phe Glu Glu Leu Val Lys Ser
740 745 750
Pro Gln Lys Ala Tyr Leu Lys Thr Ile Thr Pro Lys Phe Gln Thr Leu
755 760 765
Ile Asp Leu Ser Val Ile Glu Ile Leu Ser Arg His Ala Ser Asp Glu
770 775 780
Leu Tyr Leu Gly Glu Arg Asp Asn Pro Asn Trp Thr Ser Asp Lys Arg
785 790 795 800
Ala Leu Glu Ala Phe Lys Lys Phe Gly Asn Lys Leu Ala Glu Ile Glu
805 810 815
Lys Lys Leu Thr Gln Arg Asn Asn Asp Glu Lys Leu Arg Asn Arg His
820 825 830
Gly Pro Val Glu Met Pro Tyr Thr Leu Leu Tyr Pro Ser Ser Lys Glu
835 840 845
Gly Leu Thr Phe Arg Gly Ile Pro Asn Ser Ile Ser Ile
850 855 860
<210> 356
<211> 10
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 356
Lys Asn Pro Gln Leu Gln Asp Leu Asp Ile
1 5 10
<210> 357
<211> 11
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 357
Gly Gln Ser Thr Ser Gln Trp Gln Ser Ser Arg
1 5 10
<210> 358
<211> 10
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 358
Gln Ser Thr Ser Gln Trp Gln Ser Ser Arg
1 5 10
<210> 359
<211> 10
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 359
Gln Ser Thr Ser Gln Trp Gln Ser Ser Arg
1 5 10
<210> 360
<211> 12
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 360
Glu Glu Glu Glu Gln Gly Glu Glu Glu Ile Asn Lys
1 5 10
<210> 361
<211> 10
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 361
Pro Ser Thr Asn Pro Trp His Ser Pro Arg
1 5 10
<210> 362
<211> 14
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 362
Ala Gln Ala Gln Asp Gln Tyr Gln Gln Val Gln Tyr Ser Glu
1 5 10
<210> 363
<211> 26
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 363
Ser Glu Ala Gly Val Thr Glu Tyr Phe Asp Glu Lys Asn Glu Leu Phe
1 5 10 15
Gln Cys Thr Gly Thr Phe Val Ile Arg Arg
20 25
<210> 364
<211> 15
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 364
Gln Ala Gln Ala Gln Asp Gln Tyr Gln Gln Val Gln Tyr Ser Glu
1 5 10 15
<210> 365
<211> 13
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 365
Gly Ser Met Gly Leu Thr Phe Pro Gly Cys Pro Ala Thr
1 5 10
<210> 366
<211> 14
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 366
Gly Ser Met Gly Leu Thr Phe Pro Gly Cys Pro Ala Thr Tyr
1 5 10
<210> 367
<211> 8
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 367
Leu Gly Ala Phe Thr Pro Arg Tyr
1 5
<210> 368
<211> 10
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 368
Leu Gly Ala Phe Thr Pro Arg Tyr Gln Gln
1 5 10
<210> 369
<211> 16
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 369
Ala Leu Gly Val Asn Ala Leu Val Ala Lys Arg Leu Gln Gly Gln Asn
1 5 10 15
<210> 370
<211> 9
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 370
Leu Gly Ala Phe Thr Pro Arg Tyr Gln
1 5
<210> 371
<211> 13
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 371
Gly Ser Met Gly Leu Thr Phe Pro Gly Cys Pro Ala Thr
1 5 10
<210> 372
<211> 14
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 372
Gly Ser Met Gly Leu Thr Phe Pro Gly Cys Pro Ala Thr Tyr
1 5 10
<210> 373
<211> 14
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 373
Ser Asn Asn Pro Phe Lys Phe Leu Val Pro Ala Arg Gln Ser
1 5 10
<210> 374
<211> 9
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 374
Cys Ala Gly Val Phe Val Ile Arg Arg
1 5
<210> 375
<211> 10
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 375
Gly Ser Pro Leu Gln Ser Pro Arg Gly Phe
1 5 10
<210> 376
<211> 9
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 376
Arg Ser Ser Trp Gln Gln Gln Ser Tyr
1 5
<210> 377
<211> 11
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 377
Ser Phe Gly Gly Ser Pro Leu Gln Ser Pro Arg
1 5 10
<210> 378
<211> 11
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 378
Tyr Leu Pro Thr Lys Gln Leu Gln Pro Thr Trp
1 5 10
<210> 379
<211> 10
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 379
Gly Lys Pro Arg Ser Ser Trp Gln Gln Gln
1 5 10
<210> 380
<211> 11
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 380
Phe Gly Gly Ser Pro Leu Gln Ser Pro Arg Gly
1 5 10
<210> 381
<211> 14
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 381
Leu Asn Leu Leu Gly Phe Gly Ile Asn Ala Glu Asn Asn Glu
1 5 10
<210> 382
<211> 9
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 382
Gly Ala Leu Met Leu Pro His Tyr Asn
1 5
<210> 383
<211> 11
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 383
Gly Ala Leu Met Leu Pro His Tyr Asn Ser Arg
1 5 10
<210> 384
<211> 9
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 384
Val Phe Asp Gly Val Leu Arg Pro Gly
1 5
<210> 385
<211> 6
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 385
Leu Gln Ser Gln Asn Asp
1 5
<210> 386
<211> 11
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 386
Leu Gln Ser Gln Asn Asp Gln Arg Gly Glu Ile
1 5 10
<210> 387
<211> 14
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 387
Gln Ser Gln Asn Asp Gln Arg Gly Glu Ile Ile His Val Lys
1 5 10
<210> 388
<211> 8
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 388
Arg Gly Glu Ile Ile His Val Lys
1 5
<210> 389
<211> 8
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 389
Arg Leu Gln Ser Gln Asn Asp Gln
1 5
<210> 390
<211> 10
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 390
Arg Leu Gln Ser Gln Asn Asp Gln Arg Gly
1 5 10
<210> 391
<211> 14
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 391
Arg Leu Gln Ser Gln Asn Asp Gln Arg Gly Glu Ile Ile His
1 5 10
<210> 392
<211> 4
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 392
Met Pro Met Pro
1
<210> 393
<211> 4
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 393
Pro Met Pro Leu
1
<210> 394
<211> 6
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 394
Leu Glu Pro Asp Asn Arg
1 5
<210> 395
<211> 13
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 395
Gly Ile Ala Arg Leu Ala Gly Thr Ser Ser Val Ile Asn
1 5 10
<210> 396
<211> 6
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 396
Arg Ser Gln Asn Ile Phe
1 5
<210> 397
<211> 4
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 397
Pro Asn Ser Met
1
<210> 398
<211> 4
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 398
Gly His Pro Met
1
<210> 399
<211> 4
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 399
His Pro Met Ser
1
<210> 400
<211> 7
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 400
Phe Leu Pro Gln His Thr Asp
1 5
<210> 401
<211> 7
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 401
Glu Trp Gln Ile Asn Glu Lys
1 5
<210> 402
<211> 13
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 402
Gly Pro Gln Gln Tyr Ala Glu Trp Gln Ile Asn Glu Lys
1 5 10
<210> 403
<211> 8
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 403
Pro Gln Gln Tyr Ala Glu Trp Gln
1 5
<210> 404
<211> 7
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 404
Arg Gly Pro Gln Gln Tyr Ala
1 5
<210> 405
<211> 4
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 405
His Asn Pro Arg
1
<210> 406
<211> 0
<212> PRT
<213> 人工序列
<220>
<223> 空
<400> 406
<210> 407
<211> 0
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 407
<210> 408
<211> 4
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 408
His Pro Ser Phe
1
<210> 409
<211> 22
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 409
Pro Gly Gln Leu Gln Ser Phe Leu Leu Ser Gly Asn Gln Asn Gln Gln
1 5 10 15
Asn Tyr Leu Ser Gly Phe
20
<210> 410
<211> 22
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 410
Gln Leu Gln Ser Phe Leu Leu Ser Gly Asn Gln Asn Gln Gln Asn Tyr
1 5 10 15
Leu Ser Gly Phe Ser Lys
20
<210> 411
<211> 12
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 411
Gln Ser Phe Leu Leu Ser Gly Asn Gln Asn Gln Gln
1 5 10
<210> 412
<211> 12
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 412
Pro Gly Gln Leu Gln Ser Phe Leu Leu Ser Gly Asn
1 5 10
<210> 413
<211> 9
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 413
Gln Ser Phe Leu Leu Ser Gly Asn Gln
1 5
<210> 414
<211> 12
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 414
Gln Asn Gln Gln Asn Tyr Leu Ser Gly Phe Ser Lys
1 5 10
<210> 415
<211> 6
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 415
Tyr Leu Arg Gly Phe Ser
1 5
<210> 416
<211> 11
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 416
Pro Val Glu Met Pro Thr Leu Leu Tyr Pro Ser
1 5 10
<210> 417
<211> 13
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 417
Arg Gly Pro Gln Gln Tyr Ala Glu Trp Gln Ile Asn Glu
1 5 10
<210> 418
<211> 12
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 418
Thr Val Phe Asp Gly Val Leu Arg Pro Gly Gln Leu
1 5 10
<210> 419
<211> 9
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 419
Leu Asp Ala Leu Glu Pro Asp Asn Arg
1 5
<210> 420
<211> 16
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 420
Arg Leu Gln Ser Gln Asn Asp Gln Arg Gly Glu Ile Ile His Val Lys
1 5 10 15
<210> 421
<211> 14
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 421
Val Leu Asp Leu Ala Ile Pro Val Asn Arg Pro Gly Gln Leu
1 5 10
<210> 422
<211> 16
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 422
His Gly Pro Val Glu Met Pro Tyr Thr Leu Leu Tyr Pro Ser Ser Lys
1 5 10 15
<210> 423
<211> 14
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 423
Gly Tyr Tyr Gly Glu Gln Gln Gln Gln Pro Gly Met Thr Arg
1 5 10
<210> 424
<211> 17
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 424
Ser Glu Glu Gly Tyr Tyr Gly Glu Gln Gln Gln Gln Pro Gly Met Thr
1 5 10 15
Arg
<210> 425
<211> 6
<212> PRT
<213> 人工序列
<220>
<223> 肽
<400> 425
Leu Arg Gly Phe Ser Lys
1 5
Claims (20)
1.一种肽，其具有至多50个氨基酸并包含SEQUENCE ID NO:343或344。
2.根据权利要求1所述的肽，其由SEQUENCE ID NO: 343或SEQUENCE ID NO: 344组成。
3.根据权利要求1所述的肽，其具有至多37个连续的氨基酸。
4.权利要求2或3所述的肽的抗炎变体，与权利要求2或3所述的肽相比，其具有1至2个氨基酸改变，其中所述氨基酸改变或每个氨基酸改变选自氨基酸的插入、添加、缺失、替换。
5.根据权利要求4所述的抗炎变体，与权利要求2或3所述的肽相比，其具有1个氨基酸改变。
6.根据权利要求4-5中任一项所述的抗炎变体，其中所述改变是缺失。
7.一种经修饰肽，其为根据权利要求1-3中任一项所述的肽或权利要求4-6中任一项所述的抗炎变体。
8.根据权利要求7所述的经修饰肽，其中修饰使肽具有增加的穿透细胞的能力、增加的半衰期或增加的亲脂性。
9.根据权利要求7或8所述的经修饰肽，所述经修饰肽通过(a) 掺入保护基团，(b) 掺入非天然氨基酸，(c) 掺入侧链修饰而被修饰。
10.一种组合物，其包含一种或多种根据权利要求1至3中任一项所述的肽，或权利要求4-6中任一项所述的抗炎变体，或权利要求7-9中任一项所述的经修饰肽。
11.根据权利要求10所述的并且包含SEQUENCE ID NO:343或SEQUENCE ID NO:344的组合物。
12.根据权利要求10或11所述的组合物，其中所述组合物是粉末。
13.根据权利要求10或11所述的组合物，其配制用于局部施用。
14.一种食品或饮料、营养补充剂、个人护理组合物或药物组合物，其包含权利要求10至12中任一项所述的组合物。
15.一种个人护理组合物或化妆品组合物，其包含权利要求10至13中任一项所述的组合物。
16.根据权利要求15所述的个人护理组合物或化妆品组合物，其中所述组合物是洗发水。
17.权利要求1至3中任一项所述的肽，或权利要求4-6中任一项所述的抗炎变体，或权利要求7-9中任一项所述的经修饰肽在制备用于预防或抑制哺乳动物的炎症的药物中的用途。
18.权利要求1至3中任一项所述的肽，或权利要求4-6中任一项所述的抗炎变体，或权利要求7-9中任一项所述的经修饰肽在制备用于维持哺乳动物的肠道健康的药物中的用途。
19.根据权利要求1至3中任一项所述的肽，或权利要求4-6中任一项所述的抗炎变体，或权利要求7-9中任一项所述的经修饰肽，其用于治疗或预防哺乳动物的炎症或炎性病症的方法中。
20.权利要求19所用的肽，其中所述炎性病症选自皮肤炎性病症、关节炎性病症、心血管系统炎性病症、肺或气道炎性病症和肠道炎性病症。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111590603.8A CN114835784A (zh) | 2015-07-16 | 2016-07-18 | 抗炎肽及其用途 |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15177013.8A EP3118215A1 (en) | 2015-07-16 | 2015-07-16 | Anti-inflammatory peptides, and uses thereof |
| EP15177013.8 | 2015-07-16 | ||
| EP15177017.9A EP3118216A1 (en) | 2015-07-16 | 2015-07-16 | Cellular growth and proliferation promoting peptides, and uses thereof |
| EP15177017.9 | 2015-07-16 | ||
| PCT/EP2016/067090 WO2017009484A1 (en) | 2015-07-16 | 2016-07-18 | Anti-inflammatory peptides, and uses thereof |
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| Application Number | Title | Priority Date | Filing Date |
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| CN202111590603.8A Division CN114835784A (zh) | 2015-07-16 | 2016-07-18 | 抗炎肽及其用途 |
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| Publication Number | Publication Date |
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| CN108348568A CN108348568A (zh) | 2018-07-31 |
| CN108348568B true CN108348568B (zh) | 2021-12-28 |
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| CN201680051932.6A Active CN108348568B (zh) | 2015-07-16 | 2016-07-18 | 抗炎肽及其用途 |
| CN202111590603.8A Pending CN114835784A (zh) | 2015-07-16 | 2016-07-18 | 抗炎肽及其用途 |
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| Country | Link |
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| US (4) | US10463591B2 (zh) |
| EP (3) | EP3954700A1 (zh) |
| JP (3) | JP2018523703A (zh) |
| KR (3) | KR102307260B1 (zh) |
| CN (2) | CN108348568B (zh) |
| AU (2) | AU2016293129B2 (zh) |
| BR (1) | BR112018000660A2 (zh) |
| CA (1) | CA2992378A1 (zh) |
| DK (1) | DK3322430T3 (zh) |
| ES (1) | ES2806989T3 (zh) |
| MX (2) | MX2018000697A (zh) |
| WO (1) | WO2017009484A1 (zh) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3548058B1 (en) * | 2016-12-05 | 2022-06-22 | Nuritas Limited | Compositions comprising peptide wkdeagkplvk |
| KR102354916B1 (ko) * | 2020-02-11 | 2022-01-26 | 주식회사 쓰리빅스 | 신규 펩타이드 3ps_i014 및 이의 용도 |
| FR3114744B1 (fr) | 2020-10-02 | 2024-01-05 | Basf Beauty Care Solutions France Sas | Nouvelle utilisation d’un peptide pour améliorer le confort de la peau et/ou des muqueuses et/ou l’apparence des phanères |
| EP4265630A1 (en) * | 2020-12-16 | 2023-10-25 | Ajou University Industry-Academic Cooperation Foundation | Anti-inflammatory peptide for preventing or treating atopic dermatitis |
| CN114478702B (zh) * | 2022-04-06 | 2023-12-12 | 中南林业科技大学 | 一种米糠来源短肽及其在治疗皮肤损伤中的应用 |
| CN116253782B (zh) * | 2022-09-08 | 2024-06-04 | 浙江大学 | 一种广谱抗菌肽ktr及其应用 |
| CN116375828B (zh) * | 2022-09-08 | 2024-06-04 | 浙江大学 | 一种具有抗菌活性的抗菌肽kta及其应用 |
| FR3141066A1 (fr) * | 2022-10-24 | 2024-04-26 | Basf Beauty Care Solutions France Sas | Nouvelle utilisation d’un peptide pour améliorer la matrice extracellulaire du derme de la peau et/ou des muqueuses |
| CN116491631B (zh) * | 2023-05-26 | 2024-06-25 | 青岛农业大学 | 一种预制菜红烧肉及其制备方法 |
| CN117736271B (zh) * | 2023-06-29 | 2024-08-09 | 长沙理工大学 | 一种米渣蛋白源免疫活性肽及其应用 |
| CN117986337B (zh) * | 2024-02-02 | 2024-08-16 | 杭州御寿生物科技有限公司 | 一种提高免疫力的益生菌组合物以及在治疗疾病中的应用 |
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