CN107693837B - Preparation and application of antibacterial lubricant for tampon outer tube - Google Patents
Preparation and application of antibacterial lubricant for tampon outer tube Download PDFInfo
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- CN107693837B CN107693837B CN201710979607.2A CN201710979607A CN107693837B CN 107693837 B CN107693837 B CN 107693837B CN 201710979607 A CN201710979607 A CN 201710979607A CN 107693837 B CN107693837 B CN 107693837B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/50—Lubricants; Anti-adhesive agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/18—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing inorganic materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
- A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/452—Lubricants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/62—Encapsulated active agents, e.g. emulsified droplets
- A61L2300/622—Microcapsules
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2420/00—Materials or methods for coatings medical devices
- A61L2420/02—Methods for coating medical devices
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2420/00—Materials or methods for coatings medical devices
- A61L2420/06—Coatings containing a mixture of two or more compounds
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- General Health & Medical Sciences (AREA)
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Abstract
A preparation method of an antibacterial lubricant for a tampon outer tube belongs to the field of preparation of functional sanitary materials. The technical scheme is as follows: mixing antibacterial metal oxide, a small amount of rare earth mineral elements and a complexing agent according to a certain proportion, and then gradually dropwise adding the mixture into an oily system under the stirring condition to form a stable water-in-oil system; reacting in a reaction kettle at the temperature of 120-; the antibacterial lubricant is sprayed on the outer tube of the tampon to facilitate the implantation of the catheter, and has antibacterial effect, thereby effectively overcoming the skin allergy problem of the currently commonly used organic antibacterial agent and the precipitation discoloration problem caused by the inorganic silver ion antibacterial agent. The outer tube microorganisms are removed, the lubricity is improved, the antibacterial function is extremely strong, no stimulation or allergy is caused to a human body, and the antibacterial agent is safe and environment-friendly; especially used as the lubricant of the tampon outer tube, can effectively overcome the worry of the microorganism exceeding the standard of the tampon outer tube at present.
Description
Technical Field
The invention discloses preparation of an antibacterial lubricant and application of the antibacterial lubricant to an outer tube of a catheter type tampon, and belongs to the field of preparation of functional sanitary materials.
Background
The tube tampons are popular with many, european and american women, and 42% in the united states use tampons because they do not interfere with clothing and movement when used. Since asians are used to dislike suppositories, tampons are rarely used in women in asian countries, and in china, only 2% of women use tampons. The main reason is that many women use it for the first time, and it is difficult to implant it correctly in the body due to inexperience or poor smoothness of the plastic catheter wall; secondly, many women consider that the sanitary cotton strip and the plastic conduit wall are not sanitary enough, and worry about infection caused by bacteria introduced into the uterus, so that the chance of infection is increased, and toxic shock syndrome can be caused. The use of an antimicrobial lubricant allows for smooth implantation while eliminating concerns about the introduction of bacteria.
Antimicrobial lubricants have not been much studied, particularly no lubricant specifically targeted for use with the outer tampon tubes of the catheter type. For example, chinese patent 201510214935.4 discloses a method for preparing a lubricant for human body, which comprises mixing polyacrylamide resin with glycerol, propylene glycol and 1, 3-butylene glycol, mixing with water medium, and adding antiseptic, and has good lubricity, no color or odor, mild property, antibacterial and antiinflammatory effects, and all the ingredients can be dissolved in water, and are easy to clean without residue on the skin surface. Chinese patent 201610947042.5 provides a method for preparing a lubricant, wherein under the action of specific contents, a thickener, a lubricant, a humectant, a pH regulator, a preservative and the balance of sterile water are synergistic, so that the lubricant has strong moisture-keeping and moistening effects, also has an antibacterial effect, and has an excellent lubricating effect on gynecological speculum instruments and vagina.
The lubricants are all made of organic antibacterial and anticorrosive materials, have poor heat resistance and certain toxicity, are easy to cause irritation and allergy to skin, and cause bacteria to generate drug resistance to be mutated into super bacteria which are more harmful to human bodies. Although silver-based antibacterial agents have excellent antibacterial performance, the use of nano silver also has disadvantages, which are highlighted by its high price, easy discoloration, silver ion precipitation to produce pigmentation, and silver ion easily causes adverse effects on the environment and human health.
Disclosure of Invention
In order to solve the technical problems, the invention provides a preparation method and application of an antibacterial lubricant which is safe and environment-friendly, has an antibacterial lubricating effect and is used for an outer tube of a tampon, aiming at the defects of the existing antibacterial functional material, especially the field of the antibacterial lubricant. The antibacterial lubricant is particularly suitable for being applied to the outer tube of the catheter type tampon, removes microorganisms in the outer tube, improves the lubricity of the outer tube, has extremely strong antibacterial function, has no any irritation and allergy to human bodies, and is safe and environment-friendly; particularly, the lubricant is used as the lubricant of the tampon outer tube, can effectively overcome the worry of exceeding the standard of the microorganism of the tampon outer tube at present, is particularly suitable for women suffering from gynecological inflammation to use in the physiological period, and is beneficial to further popularization and use of the tampon.
In order to achieve the aim, the technical scheme adopted by the invention comprises the following specific process flows:
firstly, uniformly mixing nano metal oxide with a certain antibacterial effect, a small amount of rare earth mineral elements and a complexing agent according to a certain proportion to form a mixture;
secondly, gradually dripping the mixture into an oily system under the stirring state to form a stable water-in-oil system;
thirdly, placing the water-in-oil system in a heating reaction kettle at the temperature of 120-;
fourthly, cooling the water-in-oil system after reaction;
and fifthly, carrying out centrifugal separation on the cooled water-in-oil system, and removing sediments to obtain the lubricant with the antibacterial effect.
In order to further optimize the technical scheme, the nano metal oxide is colorless and tasteless, has a size of 10-100nm, has a certain antibacterial property and mainly comprises one or more of oxides of zinc, magnesium, calcium, titanium, aluminum, zirconium, barium and strontium.
In order to further optimize the technical scheme, the rare earth mineral elements are soluble rare earth element compounds, have the function of carrying out micro-doping on metal oxides to improve the antibacterial activity, and mainly comprise one or more of lanthanum, cerium, neodymium and bismuth light rare earth element compounds.
In order to further optimize the technical scheme, the complexing agent is a high molecular substance which is safe and environment-friendly to human bodies and comprises one or more of cyclodextrin, amino acid, lecithin, chitin, polyvinylpyrrolidone and polypeptide; the effect is to modify the surface of the doped nano metal oxide and improve the dispersion stability of the doped nano metal oxide in an oily system.
In order to further optimize the technical scheme, the oily system is a substance which has a lubricating effect, is safe and environment-friendly, does not have irritation or allergy to skin, and effectively coats the nano material to form a structure similar to a microcapsule, wherein the structure comprises one or more of polyethylene glycol 200, polyethylene glycol 400, polyethylene glycol 600 and glycerol.
In order to further optimize the technical scheme, the heating reaction kettle is an oil bath kettle, a hydrothermal reaction kettle or a microwave oven.
According to the technical scheme, the antibacterial metal oxide, a small amount of rare earth mineral elements and the complexing agent are mixed in a certain proportion, and are gradually dripped into an oily system under the stirring condition to form a stable water-in-oil system; reacting in a reaction kettle at the temperature of 120 plus 170 ℃ for 30-120min, cooling, and performing centrifugal separation to obtain the lubricant with the antibacterial effect. Compared with the prior art, the antibacterial lubricant provided by the invention has a very strong antibacterial function, does not have any irritation or allergy to a human body, and is safe and environment-friendly; particularly, the lubricant is used as the lubricant of the tampon outer tube, can effectively overcome the worry of exceeding the standard of the microorganism of the tampon outer tube at present, is particularly suitable for women suffering from gynecological inflammation to use in the physiological period, and is beneficial to further popularization and use of the tampon.
In summary, the invention has the following outstanding advantages:
1. the obtained antibacterial lubricant has strong antibacterial function, no irritation or allergy to human body, safety and environmental protection;
2. the obtained antibacterial lubricant is particularly suitable for an outer catheter of a tampon, has good affinity with catheter materials, and improves the lubricity of the catheter;
3. the obtained antibacterial lubricant does not have the problem of silver ion precipitation and discoloration, ensures the long-acting performance of the functions, and greatly widens the application range.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only some embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to the drawings without creative efforts.
Fig. 1 is a diagram illustrating the effect of an antibacterial lubricant for a tampon outer tube before escherichia coli is antibacterial according to the present invention;
fig. 2 is a graph showing the effect of the antibacterial lubricant for the tampon outer tube after the antibacterial action of escherichia coli according to the present invention;
fig. 3 is a graph showing the effect of an antibacterial lubricant for a tampon outer tube before staphylococcus aureus is used for antibacterial;
fig. 4 is a graph showing the effect of the antibacterial lubricant for the tampon outer tube after the antibacterial action of staphylococcus aureus according to the present invention;
FIG. 5 is a transmission electron micrograph of the antibacterial lubricant of example 1 of the present invention.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
The present invention will be described in further detail with reference to examples and specific embodiments.
Example 1:
preparation and application of an antibacterial lubricant for a tampon outer tube are carried out by mixing nano zinc oxide, nano titanium oxide, cerium nitrate and polyvinylpyrrolidone according to the proportion of 1: 0.5: 0.01: 2.5 mol ratio is dispersed in water to prepare 0.01M aqueous dispersion A; gradually dripping 20 ml of the aqueous solution A into 100 ml of glycerol B under the stirring state to obtain a water-in-oil uniform system; reacting in a hydrothermal reaction kettle at 150 ℃ for 30min, cooling, performing centrifugal separation, removing bottom sediment, and obtaining clear liquid which is the antibacterial lubricant.
Referring to the antibacterial diagrams of fig. 1, 2, 3 and 4, the antibacterial lubricant prepared according to the processing method of this example has excellent antibacterial performance. Fig. 5 is a transmission electron micrograph of the antibacterial lubricant according to the present example, in which the metal oxide in the form of clusters is uniformly dispersed and the size of the metal oxide constituting the clusters is about 20 nm.
Example 2:
referring to the attached figure 2, the preparation and application of the antibacterial lubricant for the tampon outer tube are that the nano zinc oxide, the nano titanium oxide, the cerium nitrate and the cyclodextrin are mixed according to the proportion of 1: 0.5: 0.01: 3.5 mol ratio is dispersed in water to prepare 0.02M aqueous dispersion A; gradually dripping 10 ml of the aqueous solution A into 100 ml of polyethylene glycol 400B under the stirring state to obtain a stable water-in-oil system; and (3) placing the mixture into a microwave oven, reacting for 20min at 150 ℃, cooling, performing centrifugal separation, and removing bottom sediment to obtain clear liquid, namely the antibacterial lubricant.
Referring to the antibacterial diagrams of fig. 1, 2, 3 and 4, the antibacterial lubricant prepared according to the processing method of this example has excellent antibacterial performance. Fig. 5 is a transmission electron micrograph of the antibacterial lubricant according to the present example, in which the metal oxide in the form of clusters is uniformly dispersed and the size of the metal oxide constituting the clusters is about 20 nm.
Example 3:
preparation and application of an antibacterial lubricant for a tampon outer tube are carried out by mixing nano zinc oxide, nano magnesium oxide, neodymium nitrate and lecithin according to the weight ratio of 1: 0.5: 0.01: 3.5 mol ratio is dispersed in water to prepare 0.05M aqueous dispersion A; gradually dripping 10 ml of the aqueous solution A into 100 ml of polyethylene glycol 200B under the stirring state to obtain a water-in-oil system; and (3) placing the mixture into a microwave oven, reacting for 30min at 140 ℃, cooling, performing centrifugal separation, and removing bottom sediment to obtain clear liquid, namely the antibacterial lubricant.
Referring to the antibacterial diagrams of fig. 1, 2, 3 and 4, the antibacterial lubricant prepared according to the processing method of this example has excellent antibacterial performance. Fig. 5 is a transmission electron micrograph of the antibacterial lubricant according to the present example, in which the metal oxide in the form of clusters is uniformly dispersed and the size of the metal oxide constituting the clusters is about 20 nm.
The invention aims to explore the preparation of an antibacterial lubricant and the application of the antibacterial lubricant to an outer tube of a catheter type tampon, and overcome the defects of the existing antibacterial lubricant. Mixing antibacterial metal oxide, a small amount of rare earth mineral elements and a complexing agent according to a certain proportion, and gradually dropwise adding the mixture into an oily system under the stirring condition to form a stable water-in-oil system; reacting in a reaction kettle at the temperature of 120-170 ℃ for 20-90min, cooling, and performing centrifugal separation to obtain the lubricant with the antibacterial effect. The antibacterial metal oxide is colorless and tasteless nano metal oxide, has the size within 10-100nm, and mainly comprises one or more of compounds of zinc, magnesium, calcium, titanium, aluminum, zirconium, barium and strontium: the rare earth mineral substance is a soluble rare earth element compound, has the function of improving the antibacterial activity by carrying out micro-doping on metal oxide, and mainly comprises one or more of lanthanum, cerium, neodymium and bismuth light rare earth element compounds; the complexing agent is a safe and environment-friendly high molecular substance and comprises one or more of cyclodextrin, amino acid, lecithin, chitin, polyvinylpyrrolidone and polypeptide: the oily system is a substance which has a lubricating effect, is safe, environment-friendly and has no stimulation to skin, and comprises one or more of polyethylene glycol 200, polyethylene glycol 400, polyethylene glycol 600, glycerol and the like: the reaction kettle can be an oil bath kettle, a hydrothermal reaction kettle, a microwave oven and the like. The obtained antibacterial lubricant has strong antibacterial function, has no stimulation to human body, and is safe and environment-friendly; particularly, the lubricant is used as the lubricant of the tampon outer tube, can effectively overcome the worry of exceeding the standard of the microorganism of the tampon outer tube at present, is particularly suitable for women suffering from gynecological inflammation to use in the physiological period, and is beneficial to further popularization and use of the tampon.
While only the preferred embodiments of the preparation and use of the antimicrobial lubricant for tampon outer tube of the present invention have been described above, it should be understood that various changes and modifications may be made by those skilled in the art without departing from the inventive concept of the present invention, and all such changes and modifications are intended to be within the scope of the present invention.
Claims (6)
1. The preparation method of the antibacterial lubricant for the tampon outer tube is characterized by comprising the following preparation steps:
firstly, uniformly mixing nano metal oxide with a certain antibacterial effect, a small amount of rare earth mineral elements and a complexing agent according to a certain proportion to form a mixture;
secondly, gradually dripping the mixture into an oily system under the stirring state to form a stable water-in-oil system;
thirdly, placing the water-in-oil system in a heating reaction kettle at the temperature of 120-;
fourthly, cooling the water-in-oil system after reaction;
and fifthly, carrying out centrifugal separation on the cooled water-in-oil system, and removing sediments to obtain the lubricant with the antibacterial effect.
2. The preparation of the antibacterial lubricant for the outer tube of the tampon according to claim 1, wherein the nano metal oxide is colorless and odorless, has a size of 10-100nm, has a certain antibacterial property, and comprises one or more of oxides of zinc, magnesium, calcium, titanium, aluminum, zirconium, barium, and strontium.
3. The preparation of the antibacterial lubricant for the tampon outer tube according to claim 1, wherein the rare earth mineral element is a soluble rare earth element compound, which is used for micro-doping metal oxides to improve antibacterial activity, and comprises one or more of lanthanum, cerium, neodymium and bismuth light rare earth element compounds.
4. The preparation method of the antibacterial lubricant for the tampon outer tube according to claim 1, wherein the complexing agent is a polymer substance safe and environment-friendly to human body, and comprises one or more of cyclodextrin, amino acid, lecithin, chitin, polyvinylpyrrolidone and polypeptide; the effect is to modify the surface of the doped nano metal oxide and improve the dispersion stability of the doped nano metal oxide in an oily system.
5. The preparation method of the antibacterial lubricant for the outer tube of the tampon in accordance with claim 1, wherein the oil system is a substance having a lubricating effect, being safe and environmentally friendly, and being non-irritating and non-allergenic to the skin, and the nano-materials are effectively coated to form a microcapsule-like structure comprising one or more of polyethylene glycol 200, polyethylene glycol 400, polyethylene glycol 600 and glycerol.
6. The preparation of the antibacterial lubricant for tampon outer tube according to claim 1, wherein the heating reaction kettle is an oil bath kettle, a hydrothermal reaction kettle or a microwave oven.
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| CN109112838A (en) * | 2018-06-07 | 2019-01-01 | 苏州东展羽绒服饰有限公司 | A kind of preparation method of antibacterial deodorizing nano water-proof natural feather |
| CN118044947B (en) * | 2023-12-26 | 2024-09-20 | 优立美(湖北)科技有限公司 | Sanitary cotton sliver outer catheter frosted tube body and preparation method thereof |
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| CN101569576A (en) * | 2008-05-04 | 2009-11-04 | 吴智尧 | Long-acting type condom with sterilization function and producing method thereof |
| CN107137754A (en) * | 2017-05-02 | 2017-09-08 | 江苏纳盾科技有限公司 | One kind is without precipitation Antimicrobial sanitation cotton, preparation method and application |
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| WO2008136866A2 (en) * | 2006-11-27 | 2008-11-13 | Micropyretics Heaters International, Inc. | Antimicrobal materials and coatings |
| AU2010270723A1 (en) * | 2009-07-06 | 2012-02-09 | Molycorp Minerals Llc | Ceria for use as an antimicrobial barrier and disinfectant in a wound dressing |
| US20110301553A1 (en) * | 2010-06-04 | 2011-12-08 | Smiths Medical Asd, Inc. | Antimicrobial lubricant |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101569576A (en) * | 2008-05-04 | 2009-11-04 | 吴智尧 | Long-acting type condom with sterilization function and producing method thereof |
| CN107137754A (en) * | 2017-05-02 | 2017-09-08 | 江苏纳盾科技有限公司 | One kind is without precipitation Antimicrobial sanitation cotton, preparation method and application |
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