CN106980026A - Full-automatic chemiluminescence immune analysis detection execution device - Google Patents
Full-automatic chemiluminescence immune analysis detection execution device Download PDFInfo
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- CN106980026A CN106980026A CN201710195758.9A CN201710195758A CN106980026A CN 106980026 A CN106980026 A CN 106980026A CN 201710195758 A CN201710195758 A CN 201710195758A CN 106980026 A CN106980026 A CN 106980026A
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- Prior art keywords
- cup
- reagent
- cup groove
- rotating disk
- automatic chemiluminescence
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- 238000001514 detection method Methods 0.000 title abstract description 22
- 239000003153 chemical reaction reagent Substances 0.000 claims abstract description 46
- 238000003018 immunoassay Methods 0.000 claims abstract description 20
- 239000000758 substrate Substances 0.000 claims abstract description 10
- 238000005259 measurement Methods 0.000 claims abstract description 9
- 230000003287 optical effect Effects 0.000 claims abstract description 9
- 238000005070 sampling Methods 0.000 claims abstract description 9
- 238000003556 assay Methods 0.000 claims description 6
- 238000011534 incubation Methods 0.000 claims description 5
- 230000000975 bioactive effect Effects 0.000 claims description 4
- 239000008187 granular material Substances 0.000 claims description 4
- 239000000463 material Substances 0.000 claims description 4
- 239000011343 solid material Substances 0.000 claims description 4
- 239000003795 chemical substances by application Substances 0.000 claims description 3
- 239000006249 magnetic particle Substances 0.000 claims description 3
- 230000002093 peripheral effect Effects 0.000 claims description 3
- 238000004140 cleaning Methods 0.000 abstract description 2
- 230000005540 biological transmission Effects 0.000 description 3
- NJPPVKZQTLUDBO-UHFFFAOYSA-N novaluron Chemical compound C1=C(Cl)C(OC(F)(F)C(OC(F)(F)F)F)=CC=C1NC(=O)NC(=O)C1=C(F)C=CC=C1F NJPPVKZQTLUDBO-UHFFFAOYSA-N 0.000 description 3
- 238000010586 diagram Methods 0.000 description 2
- 238000012123 point-of-care testing Methods 0.000 description 2
- 230000002596 correlated effect Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 239000007790 solid phase Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/025—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having a carousel or turntable for reaction cells or cuvettes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1004—Cleaning sample transfer devices
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- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
Abstract
The invention provides a full-automatic chemiluminescence immunoassay detection execution device, which can solve the technical problems that the existing full-automatic chemiluminescence immunoassay detection execution device is complex in structure, large in size, high in cost and incapable of realizing bedside rapid detection. It includes reaction cup and reagent cup bear and moving mechanism, sample sampling mechanism, reagent application of sample mechanism, wiper mechanism, incubate mechanism, substrate application of sample mechanism and optical measurement mechanism, its characterized in that: the bearing and moving mechanism of the reagent cup and the reaction cup comprises a rotary disc and a driving mechanism for driving the rotary disc to rotate, reagent cup grooves, reaction cup grooves and sample cup grooves which are all annular and concentrically distributed are formed in the rotary disc, the sample sampling mechanism, the reagent sampling mechanism, the cleaning mechanism, the substrate sampling mechanism and the optical measurement mechanism are sequentially distributed along the periphery of the rotary disc, and the temperature control mechanism is fixed at the bottom of the rotary disc and controls the temperature of the rotary disc.
Description
Technical field
The present invention relates to chemiluminescence immune assay field, and in particular to automatic chemiluminescence immunoassay detection is performed
Device.
Background technology
Existing automatic chemiluminescence immunoassay detects performs device, typically by sample bit of storage, reagent bit of storage,
Sample pipetting volume mechanism, reagent pipetting volume mechanism, incubation reaction mechanism, wiper mechanism, chemiluminescence measuring mechanism, cup transmission mechanism
And computer control system composition, it is characterized in, whole chemiluminescence immune assay process feeds from reaction cup, is loaded, added
Reagent, incubation, cleaning can realize automatic business processing until chemiluminescence is measured, and be operated without artificial, with treating capacity greatly, certainly
The advantages of dynamicization degree is high.But existing detection performs device is that each sample, reagent element are divided into different institutions, needs difference
There is provided, such as liquid reagent and solid phase carrier be not integration, so the complicated of instrument, volume are larger, operating cost compared with
Height, is especially not suitable for small clinical laboratory and bedside quick detection（POCT）Application, the clinical detection of practical application is just
Victory is poor.
The content of the invention
In view of the above-mentioned problems, detecting performs device the invention provides automatic chemiluminescence immunoassay, it can be solved
Existing automatic chemiluminescence immunoassay detection performs device is complicated, volume is larger, cost is high, detection efficiency is low and
The technical problem that sample enters at random can not be realized, bedside quick detection is particularly suitable for use in（POCT）With small clinical laboratory
Using.
Its technical scheme is such：Performs device includes reaction cup and reagent carrying and motion, sample sampler
Structure, reagent pipetting volume mechanism, wiper mechanism, incubation mechanism, substrate sample charging mechanism and optical measurement mechanism, it is characterised in that：It is described
Reagent cup includes opening on the drive mechanism that rotating disk and driving rotating disk rotate, the rotating disk with the carrying of reacting hole cup and motion
Provided with reagent cup groove, reaction cup groove and specimen cup groove annular in shape and be distributed with one heart, the sample sampling mechanism, the examination
Agent sample charging mechanism, the wiper mechanism, the substrate sample charging mechanism and the optical measurement mechanism are successively along the outer of the rotating disk
Week distribution, the temperature control device is fixed on the rotating disk bottom, carries out temperature control to the rotating disk.
Further, the rotating disk is circular or annular, and the reagent cup groove, reaction cup groove and specimen cup groove are along rotating disk
Center is annularly distributed；The reagent cup groove, reaction cup groove are located at the outer ring of the rotating disk, and the specimen cup groove is located at described turn
The inner ring of disk, single reaction cup groove the radially extending along the rotating disk.
Further, sample cell position is arranged with reagent cup groove position, reagent cup groove dislocation position so that reaction cup groove and reagent cup
Groove is not on same radius, and the bar code reading device realized positioned at center of turntable point can read sample automatically to be believed with reagent
Breath.
Further, the reagent cup groove and reaction cup groove are integrated in one.
Further, in the reaction cup groove, the quantity of reaction cup groove is 1 to 3；The quantity of the reagent cup groove is 1
To 6.
Further, reaction cup is provided with the reaction cup groove, the reaction cup endoperidium there are bioactive materials.
Further, it is provided with the reaction cup groove in reaction cup, the reaction cup and is provided with magnetic particle or other forms
Granule solid material, be coated with bioactive materials on the magnetic particle, the granule solid material of the other forms.
Further, the rotating disk can clockwise, rotate counterclockwise.
Further, the center of turntable point is equipped with bar code reading and takes device, and sample can be read automatically and is believed with reagent
Breath.
Further, the chemiluminescence immune assay device also includes useless cup unloading device.
The present invention is by the way that specimen cup groove, reagent cup groove and reaction cup groove are integrated on rotating disk, and sample is sampled
Mechanism, reagent pipetting volume mechanism, wiper mechanism, substrate sample charging mechanism and optical measurement mechanism are entered successively along the peripheral distribution of rotating disk
And the transfer path of each reagent is shortened, the overall integrated level of device is improved, device overall structure has been simplified, has reduced entirety
Volume, reduces cost；Meanwhile, sample sampling mechanism, reagent pipetting volume mechanism, wiper mechanism, incubation mechanism, substrate sample charging mechanism
The detection operation of the different station testing sample on rotating disk is carried out simultaneously with optical measurement mechanism, not interfere with each other, can not only
Effectively shorten the detection stand-by period of each mechanism of sample correspondence, improve detection efficiency, and can be to inoperative station
Specimen cup groove is loaded, and realizes the random entrance of sample, and this kind of random entrance can give and be realized under non-stopped status.
The detection performs device of the present invention, a reagent cup groove and reaction cup groove being integrated in one can be used for a kind of detect
Project implementation；Different reaction cups and reagent strip by loading, can not only simultaneously carry out multiple different to a sample
Immune detection project, and different immune detection projects can be carried out simultaneously to multiple samples, or multiple samples are simultaneously
Carry out the detection of same detection project.
Brief description of the drawings
Fig. 1 includes reagent cup and the carrying of reacting hole cup and the structural representation of motion for the present invention's.
Fig. 2 is the dimensional structure diagram of the automatic chemiluminescence immunoassay performs device of the present invention.
Fig. 3 is the overlooking the structure diagram of the automatic chemiluminescence immunoassay performs device of the present invention.
Embodiment
As shown in Figure 1, Figure 2 and Figure 3, automatic chemiluminescence immunoassay detection performs device, it includes pedestal 90, with
And be supported in the cup transmission mechanism 10 of pedestal 90, sample sampling mechanism 20, reagent pipetting volume mechanism 30, wiper mechanism 40, be incubated
Mechanism, substrate sample charging mechanism 50 and optical measurement mechanism 60, cup transmission mechanism 10 include rotating disk 11 and the driving of annular
Offered on the drive mechanism of turntable rotation, rotating disk along the reagent cup groove, reaction cup that center of turntable is annular in shape and is distributed with one heart
Groove and specimen cup groove 13, sample sampling mechanism 20, reagent pipetting volume mechanism 30, wiper mechanism 40, substrate sample charging mechanism 50 and optics
Measuring mechanism 60 is incubated mechanism and set and be fixed on rotating disk bottom, the entirety of rotating disk 11 is added successively along the peripheral distribution of rotating disk 11
Heat.
Reagent cup groove and reaction cup groove are integrated in one, as shown in figure 12, positioned at the outer ring of rotating disk 11, specimen cup groove 13
Positioned at the inner ring of rotating disk, single the radially extending along rotating disk of cup groove 12, the setting enables to arrange more in limited space
Many reagent cup, reaction cup and specimen cups, improve detection scale, and then further improve detection efficiency.
Chemiluminescence immune assay device also includes bar code reading device 80, and bar code reading device 80 is located at turning for annular
The center of disk 11 is simultaneously supported on pedestal 90, and reagent cup groove and reaction cup groove 12 and the specimen cup groove 13 being integrated in one interlock
Distribution, realizes that the bar code reading device positioned at center of turntable point can read sample and reagent information automatically.
Chemiluminescence immune assay device also includes useless cup unloading device 70, after sample is measured, specimen cup and
Correlated response cup is taken out by useless cup unloading device, to improve the automaticity of device.
Claims (10)
1. automatic chemiluminescence immunoassay detects performs device, it include reaction cup and reagent cup carry and motion,
Sample sampling mechanism, reagent pipetting volume mechanism, wiper mechanism, incubation mechanism, substrate sample charging mechanism and optical measurement mechanism, its feature
It is：The carrying of the reagent cup and reaction cup includes the drive mechanism that rotating disk and driving rotating disk rotate, institute with motion
State and reagent cup groove, reaction cup groove and specimen cup groove annular in shape and be distributed with one heart, the sample sampler are offered on rotating disk
Structure, the reagent pipetting volume mechanism, the wiper mechanism, the substrate sample charging mechanism and the optical measurement mechanism are successively along described
The peripheral distribution of rotating disk, the temperature control device is fixed on the rotating disk bottom, carries out temperature control to the rotating disk.
2. automatic chemiluminescence immunoassay according to claim 1 detects performs device, it is characterised in that：Described turn
Disk is circular or annular, and the reagent cup groove, reaction cup groove and specimen cup groove are annularly distributed along center of turntable.
3. automatic chemiluminescence immunoassay according to claim 2 detects performs device, it is characterised in that：The examination
Agent cup groove, reaction cup groove are located at the outer ring of the rotating disk, and the specimen cup groove is located at the inner ring of the rotating disk, the single reaction
Cup groove radially extending along the rotating disk.
4. automatic chemiluminescence immunoassay according to claim 2 detects performs device, it is characterised in that sample cell
Arranged with reagent cup groove position, reagent cup groove dislocation position position.
5. automatic chemiluminescence immunoassay according to claim 2 detects performs device, it is characterised in that：The examination
Agent cup groove and reaction cup groove are integrated in one.
6. automatic chemiluminescence immunoassay according to claim 5 detects performs device, it is characterised in that：Reaction cup
The quantity of groove is 1 to 3, and the quantity of reagent cup groove is 1 to 6.
7. automatic chemiluminescence immunoassay according to claim 2 detects performs device, it is characterised in that：It is described anti-
Answer and reaction cup is provided with cup groove, the reaction cup endoperidium there are bioactive materials.
8. automatic chemiluminescence immunoassay according to claim 2 detects performs device, it is characterised in that：It is described anti-
Answer and the granule solid material provided with magnetic particle or other forms, the magnetic are provided with reaction cup, the reaction cup in cup groove
Bioactive materials are coated with particulate, the granule solid material of the other forms.
9. automatic chemiluminescence immunoassay according to claim 1 detects performs device, it is characterised in that：Described turn
Disk can clockwise, rotate counterclockwise.
10. automatic chemiluminescence immunoassay according to claim 1 detects performs device, it is characterised in that：It is described
Chemiluminescence immune assay device also includes useless cup unloading device, and the center of turntable point is equipped with bar code reading and takes device.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710195758.9A CN106980026A (en) | 2017-03-29 | 2017-03-29 | Full-automatic chemiluminescence immune analysis detection execution device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710195758.9A CN106980026A (en) | 2017-03-29 | 2017-03-29 | Full-automatic chemiluminescence immune analysis detection execution device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106980026A true CN106980026A (en) | 2017-07-25 |
Family
ID=59339254
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710195758.9A Pending CN106980026A (en) | 2017-03-29 | 2017-03-29 | Full-automatic chemiluminescence immune analysis detection execution device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106980026A (en) |
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107449928A (en) * | 2017-09-12 | 2017-12-08 | 深圳安赛诊断技术有限公司 | A kind of rotating disc type Electrogenerated chemiluminescent immunoassay instrument |
| CN107966578A (en) * | 2017-12-26 | 2018-04-27 | 江苏柯伦迪医疗技术有限公司 | A kind of medical quick biochemical detection system and detection method |
| CN107966579A (en) * | 2017-12-26 | 2018-04-27 | 江苏柯伦迪医疗技术有限公司 | One kind has biochemistry, enzyme is exempted from and chemiluminescence rapid detection system and method |
| CN108469529A (en) * | 2018-06-05 | 2018-08-31 | 深圳天辰医疗科技有限公司 | POCT Full-automatic chemiluminescence immunoassay analysis meters |
| CN108732164A (en) * | 2018-08-07 | 2018-11-02 | 广州万孚生物技术股份有限公司 | Full-automatic chemiluminescence immunoassay analysis meter |
| CN109917145A (en) * | 2017-12-12 | 2019-06-21 | 深圳拓真生物科技有限公司 | Full-automatic chemiluminescence immunoassay analysis meter |
| WO2019127958A1 (en) * | 2017-12-26 | 2019-07-04 | 江苏英诺华医疗技术有限公司 | Medical rapid biochemical detection system and detection method |
| CN110146712A (en) * | 2019-05-27 | 2019-08-20 | 合肥运涛光电科技有限公司 | A kind of miniature rotating disc type Full-automatic luminescent immunoassay system of rotation sampling |
| CN110231472A (en) * | 2018-03-06 | 2019-09-13 | 深圳拓真生物科技有限公司 | A kind of chemical illumination immunity analysis instrument |
| CN110333363A (en) * | 2019-08-16 | 2019-10-15 | 广州阳普医疗科技股份有限公司 | A kind of full-automatic detection apparatus |
| CN110346586A (en) * | 2019-08-16 | 2019-10-18 | 广州阳普医疗科技股份有限公司 | Full-automatic detection apparatus |
| CN111812340A (en) * | 2020-05-29 | 2020-10-23 | 杭州龙鑫科技有限公司 | Temperature raising disc mechanism of full-automatic urine specific protein analyzer |
| CN118243942A (en) * | 2024-05-28 | 2024-06-25 | 宏葵生物（中国）股份有限公司 | Full-automatic chemiluminescence immunoassay instrument for medical laboratory |
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Cited By (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107449928A (en) * | 2017-09-12 | 2017-12-08 | 深圳安赛诊断技术有限公司 | A kind of rotating disc type Electrogenerated chemiluminescent immunoassay instrument |
| CN109917145B (en) * | 2017-12-12 | 2023-06-20 | 深圳拓真生物科技有限公司 | Full-automatic chemiluminescence immunoassay instrument |
| CN109917145A (en) * | 2017-12-12 | 2019-06-21 | 深圳拓真生物科技有限公司 | Full-automatic chemiluminescence immunoassay analysis meter |
| CN107966578A (en) * | 2017-12-26 | 2018-04-27 | 江苏柯伦迪医疗技术有限公司 | A kind of medical quick biochemical detection system and detection method |
| CN107966579A (en) * | 2017-12-26 | 2018-04-27 | 江苏柯伦迪医疗技术有限公司 | One kind has biochemistry, enzyme is exempted from and chemiluminescence rapid detection system and method |
| CN107966578B (en) * | 2017-12-26 | 2024-01-02 | 江苏柯伦迪医疗技术有限公司 | Medical rapid biochemical detection system and detection method |
| WO2019127958A1 (en) * | 2017-12-26 | 2019-07-04 | 江苏英诺华医疗技术有限公司 | Medical rapid biochemical detection system and detection method |
| CN110231472A (en) * | 2018-03-06 | 2019-09-13 | 深圳拓真生物科技有限公司 | A kind of chemical illumination immunity analysis instrument |
| CN108469529A (en) * | 2018-06-05 | 2018-08-31 | 深圳天辰医疗科技有限公司 | POCT Full-automatic chemiluminescence immunoassay analysis meters |
| CN108469529B (en) * | 2018-06-05 | 2024-09-13 | 深圳天辰医疗科技有限公司 | POCT full-automatic chemiluminescence immunoassay instrument |
| CN108732164A (en) * | 2018-08-07 | 2018-11-02 | 广州万孚生物技术股份有限公司 | Full-automatic chemiluminescence immunoassay analysis meter |
| CN108732164B (en) * | 2018-08-07 | 2023-09-29 | 广州万孚生物技术股份有限公司 | Full-automatic chemiluminescence immunoassay instrument |
| CN110146712A (en) * | 2019-05-27 | 2019-08-20 | 合肥运涛光电科技有限公司 | A kind of miniature rotating disc type Full-automatic luminescent immunoassay system of rotation sampling |
| CN110146712B (en) * | 2019-05-27 | 2024-04-19 | 复星诊断科技(合肥)有限公司 | Rotary sampling miniature turntable type full-automatic luminous immunoassay system |
| CN110333363A (en) * | 2019-08-16 | 2019-10-15 | 广州阳普医疗科技股份有限公司 | A kind of full-automatic detection apparatus |
| CN110346586A (en) * | 2019-08-16 | 2019-10-18 | 广州阳普医疗科技股份有限公司 | Full-automatic detection apparatus |
| CN111812340A (en) * | 2020-05-29 | 2020-10-23 | 杭州龙鑫科技有限公司 | Temperature raising disc mechanism of full-automatic urine specific protein analyzer |
| CN118243942A (en) * | 2024-05-28 | 2024-06-25 | 宏葵生物（中国）股份有限公司 | Full-automatic chemiluminescence immunoassay instrument for medical laboratory |
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Application publication date: 20170725 |