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CN106661570A8 - 通过与氨甲蝶呤选择偶联的睡美人转座子制备工程化t细胞 - Google Patents

通过与氨甲蝶呤选择偶联的睡美人转座子制备工程化t细胞 Download PDF

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Publication number
CN106661570A8
CN106661570A8 CN201580030815.7A CN201580030815A CN106661570A8 CN 106661570 A8 CN106661570 A8 CN 106661570A8 CN 201580030815 A CN201580030815 A CN 201580030815A CN 106661570 A8 CN106661570 A8 CN 106661570A8
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cell
amethopterin
coupling
sleeping beauty
beauty transposon
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CN106661570B (zh
CN106661570A (zh
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迈克尔·C·延森
苏济·本
娜塔莉·卡切洛夫斯基
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University of Washington
Seattle Childrens Hospital
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University of Washington
Seattle Childrens Hospital
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Abstract

本文描述的发明的方面包括使用具有针对通过病毒或癌症细胞呈现的分子的受体的基因工程化人T细胞，治疗、抑制、改善和/或清除受试者的病毒或癌细胞的方法，其中基因工程化T细胞是使用采用增加浓度的MTX的二级MTX选择分离的。
CN201580030815.7A 2014-04-10 2015-04-08 通过与氨甲蝶呤选择偶联的睡美人转座子制备工程化t细胞 Active CN106661570B (zh)

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US201462058973P 2014-10-02 2014-10-02
US62/058,973 2014-10-02
US201462088363P 2014-12-05 2014-12-05
US62/088,363 2014-12-05
US201462089730P 2014-12-09 2014-12-09
US62/089,730 2014-12-09
US201462090845P 2014-12-11 2014-12-11
US62/090,845 2014-12-11
PCT/US2015/024868 WO2015157386A1 (en) 2014-04-10 2015-04-08 Production of engineered t-cells by sleeping beauty transposon coupled with methotrexate selection

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