CN106387795A - 一种玉竹桑叶蜂王浆含片及生产方法 - Google Patents
一种玉竹桑叶蜂王浆含片及生产方法 Download PDFInfo
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/64—Insects, e.g. bees, wasps or fleas
- A61K35/644—Beeswax; Propolis; Royal jelly; Honey
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
- A61K36/605—Morus (mulberry)
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- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
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Abstract
本发明实施例公开了一种玉竹桑叶蜂王浆含片由下列重量份数的原料制成：天然蜂王浆50份～60份；玉竹水提取物的冻干粉20份～30份；桑叶水提取物的冻干粉10份～20份；甜味剂5份～10份；压片助流剂0.2份～0.6份。制备方法包括：准备天然蜂王浆冻干粉、玉竹水提取物的冻干粉和桑叶水提取物的冻干粉；混合原材料制备玉竹桑叶蜂王浆含片实施本发明实施例，具有如下有益效果：本发明在蜂王浆中添加了玉竹和桑叶，玉竹提取类黄酮物质与桑叶提取物脱氧野尻霉素结合形成一种新物质‑‑洗胰清糖素(cics)，具有降血糖、血脂、血压等作用。使得本发明一种玉竹桑叶蜂王浆含片与纯蜂王浆相比，降血糖功能大大加强。
Description
技术领域
本发明涉及一种保健食品及其生产方法，尤其涉及一种玉竹桑叶蜂王浆含片及生产方法。
背景技术
蜂王浆又名蜂皇浆、蜂乳，蜂王乳，蜂王浆的化学组成很复杂，蜂王浆不但含有高蛋白，并含有维生素B类和乙酰胆碱，脂肪、糖类、维生素A、维生素Bl、维生素B2、丰富的叶酸、泛酸及肌醇。还有类似乙酰胆碱样物质，而且还有多种人体需要的氨基酸和生物激素等。正因为成分复杂，所以蜂王浆的药理作用很强大。
蜂王浆含类胰岛素，能够辅助降低血糖，起到糖尿病辅助治疗的效果。但是单纯的蜂王浆对于血糖的降低效果有限，与此同时，传统的中医药中也包含了许多能够降低血糖的药材。选择合适的药材，采用现在先进的生产工艺，将其中的有效物质提取出来和蜂王浆结合在一起，对于提升蜂王浆降低血糖的功效具有重要意义。
发明内容
本发明实施例所要解决的技术问题在于，针对现在纯蜂王浆降血糖的效果不够理想的情况，提出了一种玉竹桑叶蜂王浆含片及生产方法。
为了解决上述技术问题，本发明实施例提供了一种玉竹桑叶蜂王浆含片及生产方法，该一种玉竹桑叶蜂王浆含片包括：天然蜂王浆50份～60份；玉竹水提取物的冻干粉20份～30份；桑叶水提取物的冻干粉10份～20份；甜味剂5份～10份；压片助流剂0.2份～0.6份。
其中，甜味剂为木糖醇。
其中，压片助流剂为硬脂酸镁。
一种玉竹桑叶蜂王浆含片的生产方法包括一下步骤：(1)以水提取法取得分子量小于5000D的玉竹水提取物的冻干粉，将玉竹粉碎并用纯净水浸泡，同时用低频超声波处理，然后采用冷冻离心法除去固体杂质，取上清液过5000D分子筛，取得分子量为5000D以下的玉竹粉水溶物，冷冻干燥制备玉竹水提取物的冻干粉；(2)按照步骤(1)的方法，用相同的方法取得分子量小于5000D的桑叶水提取物的冻干粉；(3)制备蜂王浆冻干粉；(4)制备玉竹桑叶蜂王浆含片，按照上述的质量分数比例称取天然蜂王浆、玉竹水提取物的冻干粉、桑叶水提取物的冻干粉、甜味剂以及压片助流剂，在沸腾锅中加入纯化水混合均匀加工，冷却干燥后进入压片机压片制得本发明一种玉竹桑叶蜂王浆含片。
其中，在步骤(1)中，离心转速为10000～12000转。
其中，蜂王浆冻干粉、玉竹水提取物的冻干粉以及桑叶水提取物的冻干粉的含水量均应小于5％。
其中，在步骤(4)中，在沸腾锅中混合原材料时1温度需要控制在18℃～23℃，湿度控制在40％～55％。
其中，在步骤(4)中，采用ZP1100压片机进行制片，工艺参数为：转速30～40转/分；工作压力7～15kN；片重0.4～0.6g。
实施本发明实施例，具有如下有益效果：本发明在蜂王浆中添加了玉竹和桑叶，玉竹提取类黄酮物质与桑叶提取物脱氧野尻霉素结合形成一种新物质--洗胰清糖素(cics)，具有降血糖、血脂、血压等作用。使得本发明一种玉竹桑叶蜂王浆含片与纯蜂王浆相比，降血糖功能大大加强。
附图说明
为了更清楚地说明本发明实施例或现有技术中的技术方案，下面将对实施例或现有技术描述中所需要使用的附图作简单地介绍，显而易见地，下面描述中的附图仅仅是本发明的一些实施例，对于本领域普通技术人员来讲，在不付出创造性劳动的前提下，还可以根据这些附图获得其他的附图。
图1是本发明提供的一种玉竹桑叶蜂王浆含片的生产方法的流程图。
具体实施方式
下面将结合本发明实施例中的附图，对本发明实施例中的技术方案进行清楚、完整地描述，显然，所描述的实施例仅仅是本发明一部分实施例，而不是全部的实施例。基于本发明中的实施例，本领域普通技术人员在没有做出创造性劳动前提下所获得的所有其他实施例，都属于本发明保护的范围。
请参见图1，图1是本发明提供的一种玉竹桑叶蜂王浆含片的生产方法的流程图。一种玉竹桑叶蜂王浆含片的生产步骤如下：
在步骤S1中，以水提取法取得分子量小于5000D的玉竹水提取物的冻干粉。
1.将玉竹清洗、除杂，并切割成小块待用。
2.将切割好的玉竹块在常温常压的条件下放置于纯净水中粉碎，然后以低频超声波处理10～40分钟，控制超声提取液的温度在10～40℃。
3.以10000～12000转冷冻离心法除去固体杂质，取上清液。
4.将上清液在1～5℃的环境温度下以5000D分子筛超滤分离，取得分子量为5000D以下的玉竹水溶性物质。
5.将上述玉竹水溶性物质冷冻干燥24～48小时制备含水量低于5％的蜂花粉水提物的冻干粉。
在步骤S2中，以水提取法取得分子量小于5000D的桑叶水提取物的冻干粉。
1.将桑叶清洗、除杂，并切割成小块待用。
2.将切割好的桑叶块在常温常压的条件下放置于纯净水中粉碎，然后以低频超声波处理10～40分钟，控制超声提取液的温度在10～40℃。
3.以10000～12000转冷冻离心法除去固体杂质，取上清液。
4.将上清液在1～5℃的环境温度下以5000D分子筛超滤分离，取得分子量为5000D以下的桑叶水溶性物质。
5.将上述桑叶水溶性物质冷冻干燥24～48小时制备含水量低于5％的蜂花粉水提物的冻干粉。
在步骤S3中，制备蜂王浆冻干粉。
将新鲜蜂王浆与冷冻干燥机中干燥36～48小时，制备含水量小于6％冻干粉。
在步骤S4中，混合原材料，制备玉竹桑叶蜂王浆含片。
1.按照如下的质量分数准备各个原材料：天然蜂王浆50份～60份；玉竹水提取物的冻干粉20份～30份；桑叶水提取物的冻干粉10份～20份；木糖醇5份～10份；硬脂酸镁0.2份～0.6份。
2.保持环境温度为18℃～23℃，湿度控制为40％～55％的情况下，将沸腾锅预热到40～60℃后，先将天然蜂王浆、玉竹水提取物的冻干粉、桑叶水提取物的冻干粉以及木糖醇加入沸腾锅内，打开蠕动泵喷纯化水进行一步制粒。制粒结束后加入硬脂酸镁混合均匀，低温冷却。
3.采用ZP1100压片机进行制片，工艺参数为：转速30～40转/分；工作压力7～15kN；片重0.4～0.6g。
木糖醇在体内新陈代谢不需要胰岛素参与，又不使血糖值升高，并可消除糖尿病人三多(多饮、多尿、多食)，因此是糖尿病人安全的甜味剂。
自古以来，中医就将桑叶作为治疗消渴症(即现代医学的糖尿病)的中药应用于临床，日本古书《吃茶养生记》也记载桑叶有改善“饮水病”(即现代医学的糖尿病)的作用。国内外研究资料证实，生物碱和多糖是桑叶中主要的降血糖成分。
桑叶的降血糖作用是通过两个途径实现的：一是通过生物碱DNJ(1-脱氧野尻霉素)对二糖类分解酶活性产生抑制作用，从而抑制小肠对双糖的吸收，降低食后血糖的高峰值；二是通过桑叶生物碱及桑叶多糖促进β细胞分必胰岛素，而胰岛素可以促进细胞对糖的利用、肝糖原合成以及改善糖代谢，最终达到降血糖的效果。
而玉竹提取类黄酮物质与桑叶提取物脱氧野尻霉素结合形成一种新物质--洗胰清糖素(cics)，进一步提高了降血糖的作用。
洗胰清糖素再和天然蜂王浆混合，蜂王浆中的多种生物酶成分起到了催化作用，进一步提高了降血糖的效果。
实施本发明实施例，具有如下有益效果：本发明在蜂王浆中添加了玉竹和桑叶，玉竹提取类黄酮物质与桑叶提取物脱氧野尻霉素结合形成一种新物质--洗胰清糖素(cics)，具有降血糖、血脂、血压等作用。使得本发明一种玉竹桑叶蜂王浆含片与纯蜂王浆相比，降血糖功能大大加强。
以上所述仅为本发明的较佳实施例而已，并不用以限制本发明，凡在本发明的精神和原则之内，所作的任何修改、等同替换、改进等，均应包含在本发明的保护范围之内。
Claims (8)
1.一种玉竹桑叶蜂王浆含片，其特征是由下列重量份数的原料制成：天然蜂王浆50份～60份；玉竹水提取物的冻干粉20份～30份；桑叶水提取物的冻干粉10份～20份；甜味剂5份～10份；压片助流剂0.2份～0.6份。
2.根据权利要求1所述的一种玉竹桑叶蜂王浆含片，其特征在于，所述甜味剂为木糖醇。
3.根据权利要求1所述的一种玉竹桑叶蜂王浆含片，其特征在于，所述压片助流剂为硬脂酸镁。
4.一种权利要求1所述的玉竹桑叶蜂王浆含片的生产方法，其特征包括一下步骤：
(1)以水提取法取得分子量小于5000D的玉竹水提取物的冻干粉，将玉竹粉碎并用纯净水浸泡，同时用低频超声波处理，然后采用冷冻离心法除去固体杂质，取上清液过5000D分子筛，取得分子量为5000D以下的玉竹粉水溶物，冷冻干燥制备玉竹水提取物的冻干粉；
(2)按照步骤(1)所述的方法，用相同的方法取得分子量小于5000D的桑叶水提取物的冻干粉；
(3)制备蜂王浆冻干粉；
(4)制备玉竹桑叶蜂王浆含片，按照上述的质量分数比例称取天然蜂王浆、玉竹水提取物的冻干粉、桑叶水提取物的冻干粉、甜味剂以及压片助流剂，在沸腾锅中加入纯化水混合均匀加工，冷却干燥后进入压片机压片制得本发明一种玉竹桑叶蜂王浆含片。
5.根据权利要求4所述的一种玉竹桑叶蜂王浆含片的生产方法，其特征在于，在所述步骤(1)中，离心转速为10000～12000转。
6.根据权利要求4所述的一种玉竹桑叶蜂王浆含片的生产方法，其特征在于，所述蜂王浆冻干粉、所述玉竹水提取物的冻干粉以及所述桑叶水提取物的冻干粉的含水量均应小于5％。
7.根据权利要求6所述的一种玉竹桑叶蜂王浆含片的生产方法，其特征在于，在所述步骤(4)中，在所述沸腾锅中混合原材料时1温度需要控制在18℃～23℃，湿度控制在40％～55％。
8.根据权利要求7所述的一种玉竹桑叶蜂王浆含片的生产方法，其特征在于，在所述步骤(4)中，采用ZP1100压片机进行制片，工艺参数为：转速30～40转/分；工作压力7～15kN；片重0.4～0.6g。
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