CN1063042A - The preparation method of Shuanghuanglian aerosol - Google Patents
The preparation method of Shuanghuanglian aerosol Download PDFInfo
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- CN1063042A CN1063042A CN 91100208 CN91100208A CN1063042A CN 1063042 A CN1063042 A CN 1063042A CN 91100208 CN91100208 CN 91100208 CN 91100208 A CN91100208 A CN 91100208A CN 1063042 A CN1063042 A CN 1063042A
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- aerosol
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- phase aerosol
- shuanghuanglian
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Abstract
The present invention is the preparation method of Shuanghuanglian aerosol, belongs to a kind of pharmaceutical preparation technology.The prepared Shuanghuanglian aerosol of the present invention is compared with injection, but has patient's self-administration, does not have the misery of injection.And characteristics such as easy to carry.Compare the directly focus administration of main disease aerosol for the treatment of with tablet with injection for SHUANGHUANLIAN such as respiratory tract infection, acute tonsillitis, viral pneumonias, therefore there is dosage little, characteristics such as curative effect height, instant effect, and for other because coccigenic infection, medicine can directly enter blood circulation and reach the effect identical with the injection administration.
Description
The invention belongs to a kind of pharmaceutical preparation technology.
SHUANGHUANLIAN is a heat and toxic materials clearing away medicine, with Fang Zhongsan flavor medicine name (Flos Lonicerae, Radix Scutellariae, Fructus Forsythiae) name.Its function cures mainly and is the heat-clearing and toxic substances removing anti-inflammation.The above three flavor medicines of pharmacological research proof all have tangible refrigeration function, and multiple coccus and bacillus are had inhibitory action.The various infection and the inflammation that are used for coccus.The modern clinical diseases such as heating that diseases such as upper respiratory tract infection, acute tonsillitis, viral pneumonia cause, chest pain, cough, laryngopharynx swelling and pain that are used for.The main preparation of SHUANGHUANLIAN is injection and injectable powder now, and it is reported that having R﹠D institution is at present studying the SHUANGHUANLIAN tablet, from existing injection and injectable powder, its clinical efficacy highly significant, injection is since approval in 1986 is produced, because effect is in the state that supply falls short of demand significantly all the time, injectable powder is in nineteen ninety approval production, it is on the basis of guaranteeing former injection curative effect, solve the injection long-term storage and can separate out sedimentary shortcoming, therefore can claim the revolution on the 'Shuang Hualian ' history, among the SHUANGHUANLIAN tablet is being studied, but from its formulation characteristic, it can only solve injection, the hardship that the powder pin need be injected, thereby use and become comparatively convenient, its dosage must be bigger than injection, the speed that takes effect does not necessarily have injection fast, and curative effect also must be more inferior than injection.
The objective of the invention is to release the SHUANGHUANLIAN novel form of that a kind of patient of being more suitable for uses, curative effect height, instant effect to society.
Shuanghuanglian aerosol of the present invention comprises two-phase, two kinds of aerosols of three-phase, and wherein the preparation method of two-phase aerosol is:
With the smart powder (can select former powder of shuanghuanglian powder injection or SHUANGHUANLIAN 95% ethanol extraction concentrated solution or the former powder of the spray-dried gained of this liquid for use) of SHUANGHUANLIAN, and cosolvent to add a certain amount of concentration respectively be in the ethanol liquid more than 95%, heating is fully stirred and is made it dissolving, cool after-filtration, filtrate is through after the assay was approved, to the slush moulding vial, by cover valve body charge into a certain amount of dichlorodifluoromethane promptly behind the gland with the filling machine fill.
Wherein the preparation method of three-phase aerosol is:
(can select the smart powder of SHUANGHUANLIAN for use the former powder of shuanghuanglian powder injection or injection stock solution, spray drying gained powder after the cyclodextrin cyclisation is handled) is ground into the following powder of 10um with jet mill or ball mill, medicine and suspending agent SPan-85 added grind well the back in newborn body, colloid mill or the dispersing emulsification machine and add isceon, open machine again and make it to grind well and become slurry.Above-mentioned slurry is crossed 250 order nylon screens.Through being sub-packed in filling machine in the bottle of the aluminum Room after the assay was approved, gland charges into a certain amount of dichlorodifluoromethane promptly by covering valve body.
Its advantage of Shuanghuanglian aerosol that the present invention produces is: but compare patient's self-administration with injection, and easy to carry; Compare with tablet with injection, for the directly disease kitchen range administration of primary symptom aerosol of SHUANGHUANLIAN such as respiratory tract infection, acute tonsillitis, viral pneumonia treatment.Therefore contain advantages such as dosage is little, curative effect is high, instant effect, and for other because coccigenic infection, medicine can directly enter blood circulation by pulmonary and reach the effect identical with the injection administration.
Best implementation method of the present invention, learning from else's experience and being ground into particle diameter by jet mill is smart powder 1000 grams of SHUANGHUANLIAN and 1000 gram SPan-85 below the 10um, with placing colloid mill to grind evenly, adds 6000 gram isceons and grinds to form homogenate.Through be sub-packed in 1000 aluminum Room bottles after the assay was approved with filling machine in, gland and by cover every bottle of valve body charge into 6 the gram dichlorodifluoromethane promptly.
Claims (10)
1, Shuanghuanglian aerosol preparation process, it is characterized in that two-phase aerosol is to finish by operations such as dosing, hydrotropy, filtration, fill, gland, filling propellant, three-phase aerosol be by former powder pulverize, sieve, operation such as batching, suspending, dilution, fill, gland, filling propellant finishes.
2, two-phase aerosol as claimed in claim 1 is characterized in that the raw material (liquid) that dosing is used, and can select the former powder of shuanghuanglian powder injection for use, also can select the SHUANGHUANLIAN concentrated solution (powder) of 95% ethanol extraction for use.
3, two-phase aerosol as claimed in claim 1, the solvent that it is characterized in that dosing are the ethanol of concentration more than 95%, and cosolvent is a propylene glycol.
4, two-phase as claimed in claim 1, three-phase aerosol, when it is characterized in that the content gross weight is 14 grams, every aerosol contains the smart powder amount of SHUANGHUANLIAN and should restrain between～3 grams 0.06.
5, three-phase aerosol according to claim 1 is characterized in that batching use former powder, can select the former powder of shuanghuanglian powder injection for use, also can select SHUANGHUANGLIAN ZHUSHEYE stock solution for use, spray drying gained powder after cyclodextrin is sealed processing.A kind of powder in back can be made into the SHUANGHUANLIAN three-phase aerosol of no bitterness.
6, three-phase aerosol as claimed in claim 1 is characterized in that batching pulverizes its granularity with former powder via which kind of grinding mode and all must reach below the 10um.
7, three-phase aerosol as claimed in claim 1, the suspending agent of usefulness of it is characterized in that adjusting is SPan-85, diluent is an isceon.
8, three-phase aerosol as claimed in claim 1 is characterized in that diluting, the temperature of three process operating system such as fill, gland must be controlled at below 23 ℃.
9, three-phase aerosol as claimed in claim 1 is characterized in that the consumption ratio of diluent isceon and propellant dichlorodifluoromethane should be controlled between 0.43～2.3 to guarantee the stability of suspension.
10, three-phase aerosol as claimed in claim 1 is characterized in that all should taking at the overall process of preparation and all raw material, adjuvants the measure of strict control moisture, and the finished product water content should be controlled at below the 300PPM.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 91100208 CN1063042A (en) | 1991-01-11 | 1991-01-11 | The preparation method of Shuanghuanglian aerosol |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 91100208 CN1063042A (en) | 1991-01-11 | 1991-01-11 | The preparation method of Shuanghuanglian aerosol |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1063042A true CN1063042A (en) | 1992-07-29 |
Family
ID=4904499
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 91100208 Pending CN1063042A (en) | 1991-01-11 | 1991-01-11 | The preparation method of Shuanghuanglian aerosol |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1063042A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004043436A1 (en) * | 2002-11-13 | 2004-05-27 | Fanzi Cong | Medicinal aerosol comprising plant essential oil and its preparation |
| WO2009151300A3 (en) * | 2008-06-13 | 2010-02-04 | Ahn-Gook Pharmaceutical Co., Ltd. | Extract of coptidis rhizoma and use thereof in treating respiratory disease |
| KR100970739B1 (en) | 2008-06-13 | 2010-07-16 | 안국약품 주식회사 | Composition comprising the extract of Coptidis Rhizoma for preventing and treating respiratory organ disease |
-
1991
- 1991-01-11 CN CN 91100208 patent/CN1063042A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004043436A1 (en) * | 2002-11-13 | 2004-05-27 | Fanzi Cong | Medicinal aerosol comprising plant essential oil and its preparation |
| WO2009151300A3 (en) * | 2008-06-13 | 2010-02-04 | Ahn-Gook Pharmaceutical Co., Ltd. | Extract of coptidis rhizoma and use thereof in treating respiratory disease |
| KR100970739B1 (en) | 2008-06-13 | 2010-07-16 | 안국약품 주식회사 | Composition comprising the extract of Coptidis Rhizoma for preventing and treating respiratory organ disease |
| RU2461388C1 (en) * | 2008-06-13 | 2012-09-20 | Ахн-Гоок Фармасьютикал Ко., Лтд. | Extract coptidis rhizoma and its use in treating respiratory disease |
| US8425953B2 (en) | 2008-06-13 | 2013-04-23 | Ahn-Gook Pharmaceutical Co., Ltd. | Extract of Coptidis rhizoma and novel use thereof in treating respiratory disease |
| USRE45524E1 (en) | 2008-06-13 | 2015-05-19 | Ahngook Pharmaceutical Co., Ltd. | Extract of Coptidis rhizoma and novel use thereof in treating respiratory disease |
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| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C01 | Deemed withdrawal of patent application (patent law 1993) | ||
| WD01 | Invention patent application deemed withdrawn after publication |