CN102120016B - Method for preparing Sichuan fritillary bulb and fructus momordicae cough relieving tablets - Google Patents
Method for preparing Sichuan fritillary bulb and fructus momordicae cough relieving tablets Download PDFInfo
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Abstract
The invention discloses a method for preparing Sichuan fritillary bulb and fructus momordicae cough relieving tablets, which comprises the following steps of: drying Chinese medicaments, coarsely crushing the Chinese medicaments, performing airflow crushing on Sichuan fritillary bulb for later use, preparing clear paste from fructus momordicae, loquat leaf and platycodon root by using a semi-bionic extraction and ethanol extraction method or a semi-bionic extraction method or an ethanol extraction and water extraction method, and adding the Sichuan fritillary bulb powder, menthol and auxiliary materials to prepare the cough relieving tablets by a conventional method. The cough relieving tablets comprise the following Chinese medicament components in parts by weight: 25 to 60 parts of Sichuan fritillary bulb, 8 to 25 parts of fructus momordicae, 300 to 500 parts of loquat leaf, 80 to 250 parts of platycodon root and 0.2 to 1.2 parts of menthol. After the Chinese medicaments are coarsely crushed in the method, the contact area of the Chinese medicaments and a solvent is increased in the extraction process, so the extraction time is short, the transfer rate is high, the time is saved, the production period is quickened, the energy is saved, the utilization rate of the raw materials is improved, and effective ingredients of the raw medicaments are kept.
Description
Technical field:
The invention belongs to the Chinese medicine preparation technical field, relate to a kind of preparation method of Chuanbei Luohan cough-relieving sheet.
Background technology:
At present, existing treatment cough-relieving medicament adopts Chinese medicine and Western medicine more.Western medicine belongs to chemicals, and multiplex analgesic, the antitussive for the treatment of cough-relieving, antibiotic medicine are main, the less stable of curative effect, and side effect is large, and long-term taking is larger to injury of human, belongs to control table method, can't reach the equilibrium between yin and yang of the person and the effect of radical cure.Adopt the treatment of Chinese medicine prescription, have preferably therapeutic effect.But the Chinese medicinal formulae dosage is large, need to decoct and the medicine of a warm nature, and decocting herb often to exist active ingredient incomplete, also have " thick, black, large " problem, bring inconvenience to the patient.Therefore, people also once developed cough-relieving distillate medicinal water and cough-relieving unguentum.In order to develop the treatment by Chinese herbs advantage, develop more cough-relieving dosage form modern Chinese medicine products, allow Chinese medicine meet the needs of the world, to adapt to the whole mankind's needs.
Chinese patent CNl366942A, application number 01102136.5, nano Chuanbei Luohan cough-relieving preparation medicine and preparation method thereof.This invention is the medicament made from the nano raw material of following weight proportion: 20～55 parts of nano Sichuan fritillary bulb mothers, nanometer is criticized 350～600 parts on a leaf, 80～200 parts of nanometer Radix Platycodoniss, 0.5～3 part of nanometer Mentholum, 8～25 parts of nanometer Fructus Momordicaes.And adopt following method to make:
One of method of above-mentioned each component being made medicine of the present invention is:
1, divide and get each ignorant Chinese crude drug, become the common Chinese decoction pieces according to Preparation process of Chinese Pharmacopoeia version in 2000,
2, divide and get each ignorant common Chinese decoction pieces, be processed into Nano Chinese medicine piece, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20～3,000,000,000 seconds do the change in polarity motion, and the temperature of its microwave extracting is 30～60 ℃, 1～10 hour time;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30～60 ℃, and the time is 3～72 hours, collects in addition volatile material in the Chinese medicine simultaneously;
2. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, effluxvelocity 330～990/ seconds, 30～60 ℃ of temperature, under 0 to the 0.05MPa pressure, with the instantaneous drying of hypersonic velocity jet, namely make Nano Chinese medicine piece.
3, Nano Chinese medicine piece (powder) is prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of this invention medicine method for making is:
1, be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30～60 ℃, 1～10 hour time;
2, above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30～60 ℃, and the time is 3～72 hours, collects in addition volatile material in the Chinese medicine simultaneously;
3, decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, effluxvelocity 330～990 meter per seconds, 30～60 ℃ of temperature, under 0 to the 0.05MPa pressure, with the instantaneous drying of hypersonic velocity jet, get the Chuanbei Luohan cough-relieving preparation nano powder;
4, its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
Described solvent is water or ethanol, and its concentrating under reduced pressure is conventional scheme.
This characteristic feature of an invention is: made drug material has reached nanoscale, common Chuanbei Luohan cough-relieving electuary preparation material is micron or the above particle diameter of millimeter, can only cross 80～120 mesh sieves, the drug material that this invention is made, particle diameter is at 0.1～200nm, the overwhelming majority can be crossed 1200～1500 mesh sieves less than 100nm.Adopt the steps such as microwave extracting, concentrating under reduced pressure, supersonic jet technology spray drying to make.
Another characteristics of this invention are: do not need to add any adjuvant, and rapidly disintegrate of solid preparation, solid is scattered in water, absorbs fully, and bioavailability is high, and the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
Chinese patent CNl634432A, application number 200410088412.1, tendril-leaved fritillary bulb cough-relieving drop pills.This invention is in weight portion (g, kg), according to Bulbus Fritillariae Cirrhosae 2.6%, batch the ratio of leaf 68.2%, the Radix Stemonae 12.2%, Radix Peucedani 7.3%, Radix Platycodonis 4.7%, Cortex Mori 4.9%, Mentholum 1%, get above seven hide some, except Mentholum, all the other Six-elements decoct with water secondary, 2.5h for the first time, 2h for the second time, collecting decoction filters, it is 1.3～1.6 that filtrate is concentrated into density, add Mentholum, be stirred into thick paste and get final product, or thick paste is dry through low-temperature reduced-pressure, pulverize, namely get drug extract dry powder.
The mixture of one or more from the pharmaceutically suitable carrier such as above drug extract adding substrate-Polyethylene Glycol, s6, cyclodextrin, poloxamer, carboxymethyl starch sodium, sodium lauryl sulphate, stearic acid, sodium stearate, glycerin gelatine, Lac, the weight portion meter, drug extract: substrate=1: 1～1: 9.
Preparation method:
1, according to the given ratio of prescription, accurately takes by weighing drug extract and substrate, be placed on while stirring heating in the heating container, until it is for subsequent use to obtain containing the fused solution of drug extract and substrate and/or emulsion and/or suspension;
2, adopt homemade or general pill dripping machine (such as the T2mw-1 type pill dripping machine of Changzheng Tianmin High Science ﹠ Technology Co., Ltd., Beijing's production), and the temperature control system of adjustment pill dripping machine, make the water dropper temperature heating of pill dripping machine and remain on (50～90) ℃, the temperature cooling of condensing agent also remains on (40～-5) ℃;
3, the temperature for the treatment of condensing agent in pill dripping machine water dropper and the condensation column is stable being in 2 step of very wise move during desired state of temperature respectively, fused solution and/or emulsion and/or the suspension that will contain drug extract and substrate, under the state of insulation, place in the water dropper storage vat that drips nine machines, splash in the condensing agent by water dropper.Condensing agent can be any one in liquid paraffin, methyl-silicone oil, the vegetable oil;
4, will be shunk nine taking-ups of dripping of molding by the pill dripping machine outlet, remove the surface condensation agent, be drying to obtain.
This invention is to adopt intermediate water decocting method extraction Effective Component of Chinese Medicine and prepare tendril-leaved fritillary bulb cough-relieving drop pills.
Summary of the invention:
The objective of the invention is: for Chinese medicine prescription " thick, black, large " problem, in order to make things convenient for the patient to take treatment, aim to provide the advantage that a kind for the treatment of by Chinese herbs is effective, safe and reliable, have no side effect, medicament contg is high, taking dose is little, and taking dose is accurate, taking convenience, and be convenient to the modern Chinese medicine product that meets the needs of the world of going out to carry, a kind of preparation method of Chuanbei Luohan cough-relieving sheet is provided.
Technical scheme of the present invention is such:
The preparation method of a kind of Chuanbei Luohan cough-relieving sheet of the present invention, be according to the traditional Chinese medical science to the theory of health preserving with execute and control principle, according to tonify deficiency yin nourishing, clearing away heat and cooling blood, promoting the production of body fluid for nourishing the lung, relieving cough and asthma, activating QI to eliminate phlegm, laxation toxin expelling, deficiency and excess is ruled together and the Traditional Chinese Medicine prescription of giving consideration to both the incidental and fundamental.Adopt modern biological extraction technology, utilize jet mill with former medicine make between the material at high-energy air-flow under room temperature, the drying regime, between material and the gas, between material and the wall physical actions such as mutual collision, friction, shearing, impact, extruding occur, thereby reach the pulverizing purpose, its granularity is little, surface area is large, dissolubility, dispersive property improve, and keep former the effective elements of the medicine.And adopt semi-bionic extraction or the alcohol extraction+water extraction of modern biological extraction, high efficiency extraction effective components of Chinese medicinal.
The present invention is achieved in that
The preparation method of Chuanbei Luohan cough-relieving sheet, comprise first each Chinese medicine is carried out dried, coarse pulverization, after the Bulbus Fritillariae Cirrhosae coarse pulverization, carrying out airflow counter-collision with jet mill pulverizes, for subsequent use, Fructus Momordicae, Folium Eriobotryae and Radix Platycodonis prepare clear paste with semi-bionic extraction+alcohol extracting method or semi-bionic extraction or alcohol extraction+water extraction lixiviate, extracting clear paste later on also can be with the clear paste drying under reduced pressure, pulverize to get drug extract dry powder, then add Bulbus Fritillariae Cirrhosae powder, Mentholum and adjuvant and prepare cough stopping tablet with conventional method, comprise Chinese medicine ingredients and parts by weight by following proportioning:
25～60 parts of Bulbus Fritillariae Cirrhosaes, 8～25 parts of Fructus Momordicaes, 300～500 parts of Folium Eriobotryaes, 80～250 parts of Radix Platycodoniss, 0.2～1.2 part of Mentholum, pharmaceutic adjuvant and medicinal solvent are an amount of;
Above-described pharmaceutic adjuvant comprises filler, correctives and lubricant, and the parts by weight proportioning of filler, correctives and lubricant is 30～50: 3～15: 0.3～0.6.
Above-described filler comprises starch, carboxymethyl starch, sodium carboxymethyl cellulose, dextrin, calcium hydrogen phosphate and other one or more mixture of medicinal filler.
Above-described correctives is white sugar.
Above-described lubricant comprises Polyethylene Glycol, calcium stearate, Pulvis Talci and other one or more mixture of medicinal lubricant.
Above-described medicinal solvent comprises water and one or more mixture of the medicinal alcoholic solvent of organic solvent ethanol, propanol, n-butyl alcohol and methanol commonly used.
Above-described semi-bionic extraction+alcohol extracting method prepares the method for clear paste, will be through Fructus Momordicae, Folium Eriobotryae and the Radix Platycodonis Chinese medicine of coarse pulverization, semi-bionic extraction liquid with 3～8 times of Chinese medicine weight portions decocts 1～2 time, 40～95 ℃ of control temperature, each 0.5～1 hour time, extracting solution merges filtration, the pH value to 6.5 of neutralising extract～7.5, left standstill 8～12 hours, and filtered, filtrate is for subsequent use; The alcoholic solvent that medicinal residues add 3～6 times of Chinese medicine weight portions decocts 1 time, 35～55 ℃ of control temperature, 1～2 hour time, filter the extracting solution that removes slag to get, merge extractive liquid,, alcoholic solvent is reclaimed in distilling under reduced pressure, it is 1.15～1.28 clear paste that decompression dehydration is condensed into relative density, extracts clear paste and also can with clear paste at 65～80 ℃ of drying under reduced pressure, pulverize to such an extent that drug extract dry powder is for subsequent use later on.
Above-described semi-bionic extraction prepares the method for clear paste, will be through Fructus Momordicae, Folium Eriobotryae and the Radix Platycodonis Chinese medicine of coarse pulverization, semi-bionic extraction liquid with 3～8 times of Chinese medicine weight portions decocts 2 times, 40～95 ℃ of control temperature, each 0.5～1 hour time, extracting solution merges filtration, the pH value to 6.5 of neutralising extract～7.5, left standstill 8～12 hours, filter, it is 1.15～1.28 clear paste that concentrating under reduced pressure becomes relative density, extracts clear paste and also can with clear paste at 65～80 ℃ of drying under reduced pressure, pulverize to such an extent that drug extract dry powder is for subsequent use later on.
Above-described semi-bionic extraction liquid refers to the acidic aqueous solution that is made into hydrochloric acid or acetic acid and water also can adopt mixed acid, and the pH value of water solution after acid and water are prepared is 2～5.
Above-described alcohol extraction+water extraction prepares the method for clear paste, will be through Fructus Momordicae, Folium Eriobotryae and the Radix Platycodonis Chinese medicine of coarse pulverization, and the solvent that adds 3～8 times of Chinese medicine weight portions decocts 2 times, 35～55 ℃ of control temperature, each 1～2.5 hour time, filter, remove slag to such an extent that extracting solution is for subsequent use; The aqueous solvent that medicinal residues add 3～6 times of Chinese medicine weight portions decocts 1 time, 40～95 ℃ of control temperature, 1～2 hour time, filter and remove residue gets extracting solution, merge extractive liquid,, be condensed into relative density and be 1.05～1.20 thick clear paste, rear adding organic solvent ethanol is to containing pure weight 50～70%, stir, left standstill 8～12 hours, filter, filtrate is through decompression and solvent recovery, and concentrating under reduced pressure to become relative density be 1.15～1.28 clear paste, extract clear paste and also can with clear paste at 65～80 ℃ of drying under reduced pressure, pulverize to such an extent that drug extract dry powder is for subsequent use later on.
Clear paste or the drug extract dry powder of above-described semi-bionic extraction+alcohol extracting method or semi-bionic extraction or alcohol extraction+water extraction lixiviate preparation, according to Chinese Pharmacopoeia version two-shift system in 2010 agent standard, other makes pill, powder, suppository, granule, capsule, drop pill, aerosol and oral solution.
Below be the pharmacological property that the preparation method of a kind of Chuanbei Luohan cough-relieving sheet of the present invention adopts former medicine:
(1) Bulbus Fritillariae Cirrhosae: Bulbus Fritillariae Cirrhosae (Bulbus Fritillariae Cirrhosae).Bitter, sweet, be slightly cold.Enter lung, heart channel.Have clearing heat and moistening lung, preventing phlegm from forming and stopping coughing, the effect of mass dissipating and swelling eliminating.Be used for lung-heat type cough, the few expectorant of dry cough, deficiency of YIN chronic cough and sputum with blood.
(2) Fructus Momordicae: Fructus Momordicae (Momordica grosvenori Swingle).Fruits nutrition is worth high, is rich in vitamin C, contains 400～500 milligrams in per 100 gram fresh fruits, contains mogroside (esgoside), and other contains fructose, aminoacid, flavone, and its sweet substance is non-sucrose composition, sweet 300 times than sucrose.Cool in nature, sweet in the mouth is returned lung, large intestine channel.Have clearing away heat and cooling blood, the effect of the cough-relieving of promoting the production of body fluid, moistening the lung and resolving phlegm, laxation relieving constipation.Be used for the treatment of phlegm-heat cough, laryngopharynx swelling and pain, flat the body inflammation of choosing, acute gastritis and dryness of the intestine constipation.
(3) Folium Eriobotryae: Folium Eriobotryae (Eriobotrya japonica).Hardship is slightly cold, and returns lung, the stomach warp.Clearing away lung-heat to relieve cough, stopping nausea and vomiting by lowering the adverse flow of QI.Be used for the cough due to lung-heat, QI rising in reverse order dyspnea with rapid respiration, gastropyretic vomiting and hiccup.
(4) Radix Platycodonis: Radix Platycodonis (Platycodon grandiflorus).Bitter in the mouth, suffering, slightly warm in nature enters lung meridian.Has lung qi dispersing, sore-throat relieving, the effect of eliminating phlegm and stopping cough.Be used for cough with copious phlegm, uncomfortable in chest not smooth, laryngopharynx swelling and pain, bronchitis, lung abscess and pleuritis.
(5) Mentholum: Mentholum (Mentholum) claims again menthol, acrid in the mouth, cool in nature.Has dispelling wind, heat clearing away.Be used for anemopyretic cold, headache, conjunctival congestion, laryngopharynx swelling and pain, toothache and skin pruritus.
Advantage of the present invention and good effect:
1, the preparation method of a kind of Chuanbei Luohan cough-relieving sheet of the present invention, overcome Chinese medicine prescription dosage large, need to decoct and the medicine of a warm nature, and decocting herb often exists active ingredient incomplete " thick, black, large " problem, bring convenience to the patient and take and consumption advantage accurately.Brought into play the advantage that treatment by Chinese herbs is effective, safe and reliable, have no side effect, the preparation method of the modern Chinese medicine Chuanbei Luohan cough-relieving flake products that meets the needs of the world is provided, to adapt to human needs to Chinese patent medicine.
2, Chinese medicine increases with the contact area of solvent in extraction process after crushed, so extraction time is short, the rate of transform is high, both saved time, accelerated the production cycle, again energy savings, also improve the utilization rate of raw material, and keep former the effective elements of the medicine, the high efficiency extraction effective components of Chinese medicinal.
Description of drawings:
Fig. 1: be semi-bionic extraction+alcohol extracting method process flow diagram;
Fig. 2: be the semi-bionic extraction process flow diagram;
Fig. 3: be alcohol extraction+water extraction process flow diagram.
The specific embodiment:
Below in conjunction with drawings and Examples, the present invention is described in further detail.
Embodiment 1:
(1) prescription (parts by weight):
55 parts of Bulbus Fritillariae Cirrhosaes, 25 parts of Fructus Momordicaes, 380 parts of Folium Eriobotryaes, 220 parts of Radix Platycodoniss, 1 part of Mentholum.
Adjuvant: 20 parts of sodium carboxymethyl cellulose, 10 parts in dextrin, 10 parts of calcium hydrogen phosphate, 0.4 part of 10 parts of white sugars and calcium stearate.
(2) preparation method:
Fig. 1 is for subsequent use with pulverizing with jet mill after the Bulbus Fritillariae Cirrhosae coarse pulverization, Fructus Momordicae, Folium Eriobotryae and Radix Platycodonis Chinese medicine through coarse pulverization, semi-bionic extraction liquid with 6 times of Chinese medicine weight portions decocts 1 time, 65 ℃ of control temperature, are filtered at 1 hour time, the pH value to 6.8 of neutralising extract, left standstill 8～12 hours, and filtered, filtrate is for subsequent use; The alcohol solvent that medicinal residues add 5 times of Chinese medicine weight portions boils 1 time, 55 ℃ of control temperature, 1 hour time, filter, go medicinal residues to get extracting solution, merge extractive liquid,, distilling under reduced pressure Recycled ethanol solvent, decompression dehydration is condensed into relative density and is 1.28 clear paste, add Bulbus Fritillariae Cirrhosae powder, Mentholum and pharmaceutic adjuvant, mix homogeneously is pulverized drying, tabletting, packing namely get the cough stopping tablet finished product.
Embodiment 2:
(1) prescription (parts by weight):
60 parts of Bulbus Fritillariae Cirrhosaes, 25 parts of Fructus Momordicaes, 320 parts of Folium Eriobotryaes, 200 parts of Radix Platycodoniss, 0.8 part of Mentholum.
Adjuvant: 15 parts of starch, 20 parts in dextrin, 8 parts of white sugars, 0.2 part of 0.3 part of calcium stearate and Pulvis Talci.
(2) preparation method:
Fig. 2 is for subsequent use with pulverizing with jet mill after the coarse pulverization of crude drug Bulbus Fritillariae Cirrhosae first, Fructus Momordicae, Folium Eriobotryae and Radix Platycodonis are through screening, being made into pH value with acetic acid and water after the coarse pulverization is that 5 times of Chinese medicine weight portions of 4.2 semi-bionic extraction liquid decoct 2 times, 68～73 ℃ of control temperature, each 0.7～1 hour time, extracting solution merges filtration, the pH value to 7.2 of neutralising extract left standstill 12 hours, filtered, it is 1.20 clear paste that decompression dehydration is condensed into relative density, extract after the clear paste, clear paste at 70～75 ℃ of drying under reduced pressure, is pulverized to get drug extract dry powder, add Bulbus Fritillariae Cirrhosae powder, Mentholum and pharmaceutic adjuvant, mix homogeneously is pulverized drying, tabletting, packing namely get the cough stopping tablet finished product.
Embodiment 3:
(1) prescription (parts by weight):
55 parts of Bulbus Fritillariae Cirrhosaes, 20 parts of Fructus Momordicaes, 300 parts of Folium Eriobotryaes, 0.8 part of 250 parts of Radix Platycodoniss and Mentholum.
Adjuvant: 30 parts of hydroxypropyl celluloses, 5 parts of Polyethylene Glycol, 6 parts of white sugars, 0.2 part of Polyethylene Glycol, 0.1 part of Pulvis Talci, 3000 parts in 3000 parts of solvent 60% ethanol and water.
(2) preparation method:
Fig. 3 is for subsequent use with pulverizing with jet mill after the coarse pulverization of crude drug Bulbus Fritillariae Cirrhosae, and Fructus Momordicae, Folium Eriobotryae and Radix Platycodonis add ethanol and decoct through screening after the coarse pulverization, 56 ℃ of control temperature, and 0.6 hour time, filter, remove slag to such an extent that the alcohol extraction extracting solution is for subsequent use.Slag is decocted with water, 90 ℃ of control temperature, 1.4 hours time, filter, the water extraction extracting solution removes slag to get.Merge extractive liquid,, Distillation recovery ethanol, then to become relative density be 1.10 thick clear paste to concentrating under reduced pressure, adds ethanol to containing pure weight 60% again, stirs, and left standstill 8 hours, filters.Filtrate is through the decompression recycling ethanol solvent, and decompression dehydration to be condensed into relative density be 1.22 clear paste, clear paste at 80 ℃ of lower drying under reduced pressure, is pulverized to get drug extract dry powder, add Bulbus Fritillariae Cirrhosae powder, Mentholum and pharmaceutic adjuvant, mix homogeneously is pulverized, drying, tabletting, packing namely gets the cough stopping tablet finished product.
Embodiment 4:
(1) prescription (parts by weight):
45 parts of Bulbus Fritillariae Cirrhosaes, 15 parts of Fructus Momordicaes, 435 parts of Folium Eriobotryaes, 0.8 part of 130 parts of Radix Platycodoniss and Mentholum.
Adjuvant: 10 parts of sodium carboxymethyl cellulose, 25 parts of starch, 11 parts of white sugars, 0.4 part of calcium stearate, 100 parts of solvent 70% ethanol, 2600 parts in 3500 parts of n-butyl alcohol and water.
(2) preparation method:
Fig. 3 is for subsequent use with pulverizing with jet mill after the coarse pulverization of crude drug Bulbus Fritillariae Cirrhosae, and Fructus Momordicae, Folium Eriobotryae and Radix Platycodonis decoct with water after the coarse pulverization through screening, 80 ℃ of control temperature, and time 2 h filters, and removes slag to such an extent that the water extraction extracting solution is for subsequent use.Slag is added butanol solution decoct, the control temperature 50 C, 1 hour time, filter, the alcohol extraction extracting solution removes slag to get.Merge extractive liquid,, the Distillation recovery n-butyl alcohol, then to be condensed into relative density be 1.00 thick clear paste to decompression dehydration, adds ethanol to containing pure weight 60% again, stirs, and left standstill 10 hours, filters.Filtrate is through the decompression recycling ethanol solvent, and concentrating under reduced pressure to become relative density be 1.26 clear paste, clear paste at 75 ℃ of lower drying under reduced pressure, is pulverized to get drug extract dry powder, add Bulbus Fritillariae Cirrhosae powder, Mentholum and pharmaceutic adjuvant, mix homogeneously is pulverized, drying, tabletting, packing namely gets the cough stopping tablet finished product.
Claims (4)
1. the preparation method of a Chuanbei Luohan cough-relieving sheet is characterized in that: comprise first each Chinese medicine is carried out dried, coarse pulverization is wherein carried out airflow counter-collision with jet mill after Bulbus Fritillariae Cirrhosae 25～60 weight portion coarse pulverizations and pulverized, and is for subsequent use; Fructus Momordicae 8～25 weight portions, Folium Eriobotryae 300～500 weight portions and Radix Platycodonis 80～250 weight portions prepare clear paste with semi-bionic extraction+alcohol extracting method or semi-bionic extraction or alcohol extraction+water extraction lixiviate, or with the clear paste drying under reduced pressure, pulverize to get drug extract dry powder, then adding Bulbus Fritillariae Cirrhosae powder, Mentholum 0.2～1.2 weight portion and parts by weight proportioning is 30～50: 3～15: adjuvant and the medicinal solvent of 0.3～0.6 filler, correctives and lubricant are an amount of, prepare cough stopping tablet with conventional method;
Described filler comprises starch, carboxymethyl starch, sodium carboxymethyl cellulose, dextrin, calcium hydrogen phosphate and other one or more mixture of medicinal filler;
Described lubricant comprises Polyethylene Glycol, calcium stearate, Pulvis Talci and other one or more mixture of medicinal lubricant;
Described medicinal solvent comprises water and organic solvent ethanol, propanol, n-butyl alcohol and one or more mixture of methanol medicinal solvent commonly used;
Described semi-bionic extraction adopts the semi-bionic extraction liquid of hydrochloric acid or acetic acid and water or its mixed acid and water secure ph 2～5,40～95 ℃ of control temperature, 0.5～1 hour time.
2. the preparation method of Chuanbei Luohan cough-relieving sheet according to claim 1, it is characterized in that: described semi-bionic extraction+alcohol extracting method prepares the method for clear paste, be will be through Fructus Momordicae, Folium Eriobotryae and the Radix Platycodonis Chinese medicine of coarse pulverization, decoct 40～95 ℃ of control temperature 1～2 time with the semi-bionic extraction liquid of 3～8 times of Chinese medicine weight portions, each 0.5～1 hour time, extracting solution merges filtration, and left standstill 8～12 hours the pH value to 6.5 of neutralising extract～7.5, filter, filtrate is for subsequent use; The alcoholic solvent that medicinal residues add 3～6 times of Chinese medicine weight portions decocts 1 time, 35～55 ℃ of control temperature, 1～2 hour time, filter the extracting solution that removes slag to get, merge extractive liquid,, alcoholic solvent is reclaimed in distilling under reduced pressure, it is 1.15～1.28 clear paste that decompression dehydration is condensed into relative density, or with clear paste at 65～80 ℃ of drying under reduced pressure, pulverize to such an extent that drug extract dry powder is for subsequent use.
3. the preparation method of Chuanbei Luohan cough-relieving sheet according to claim 1, it is characterized in that: described semi-bionic extraction prepares the method for clear paste, will be through the Fructus Momordicae of coarse pulverization, Folium Eriobotryae and Radix Platycodonis Chinese medicine, semi-bionic extraction liquid with 3～8 times of Chinese medicine weight portions decocts 2 times, 40～95 ℃ of control temperature, each 0.5～1 hour time, extracting solution merges filtration, the pH value to 6.5 of neutralising extract～7.5, left standstill 8～12 hours, and filtered, it is 1.15～1.28 clear paste that concentrating under reduced pressure becomes relative density, or with clear paste at 65～80 ℃ of drying under reduced pressure, pulverize to such an extent that drug extract dry powder is for subsequent use.
4. the preparation method of Chuanbei Luohan cough-relieving sheet according to claim 1, it is characterized in that: described alcohol extraction+water extraction prepares the method for clear paste, will be through Fructus Momordicae, Folium Eriobotryae and the Radix Platycodonis Chinese medicine of coarse pulverization, the solvent that adds 3～8 times of Chinese medicine weight portions decocts 2 times, 35～55 ℃ of control temperature, each 1～2.5 hour time, filter, remove slag to such an extent that extracting solution is for subsequent use; The aqueous solvent that medicinal residues add 3～6 times of Chinese medicine weight portions decocts 1 time, 40～95 ℃ of control temperature, 1～2 hour time, filter and remove residue gets extracting solution, merge extractive liquid,, be condensed into relative density and be 1.05～1.20 thick clear paste, rear adding organic solvent ethanol is to containing pure weight 50～70%, stir, left standstill 8～12 hours, filter, filtrate is through decompression and solvent recovery, and concentrating under reduced pressure to become relative density be 1.15～1.28 clear paste, or with clear paste at 65～80 ℃ of drying under reduced pressure, pulverize to such an extent that drug extract dry powder is for subsequent use.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2011100424645A CN102120016B (en) | 2011-02-22 | 2011-02-22 | Method for preparing Sichuan fritillary bulb and fructus momordicae cough relieving tablets |
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| CN2011100424645A CN102120016B (en) | 2011-02-22 | 2011-02-22 | Method for preparing Sichuan fritillary bulb and fructus momordicae cough relieving tablets |
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| CN113876878A (en) * | 2020-11-10 | 2022-01-04 | 深圳蔚多科技有限公司 | Herbal formula for promoting production of body fluid and relieving cough and preparation method |
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| CN1366942A (en) * | 2001-01-20 | 2002-09-04 | 杨孟君 | Nano Chuanbei Luohan cough-relieving preparation medicine and preparation method |
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| CN1366942A (en) * | 2001-01-20 | 2002-09-04 | 杨孟君 | Nano Chuanbei Luohan cough-relieving preparation medicine and preparation method |
Non-Patent Citations (3)
| Title |
|---|
| 刘红宁等.含贝母中成药剂型与工艺比较分析.《中成药》.2007,第29卷(第08期),1204-1207. * |
| 卫生部.川贝罗汉止咳冲剂.《卫生部颁药品标准 中药成方制剂第八册》.1993,17. * |
| 杨茉等.半仿生技术在复方中药提取中的应用进展.《时珍国医国药》.2008,第19卷(第08期),1946-1947，第1947页倒数第1段、倒数第3段. * |
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