CN106173614A - A kind of have compositions increasing bone substance density improving function and preparation method thereof - Google Patents
A kind of have compositions increasing bone substance density improving function and preparation method thereof Download PDFInfo
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Abstract
The present invention relates to a kind of compositions with increase bone substance density improving function and preparation method thereof.Its contained active component is calcium carbonate, Glucosamine sulfate potassium chloride, chondroitin sulfate, phosphopeptide caseinate, Cortex Eucommiae extract, Rhizoma Curcumae Longae extract；The present invention is the most scientifically to be assembled by above-mentioned raw materials, is made into oral formulations, said preparation taking convenience, the experiment proved that have increase bone substance density improving function.
Description
Technical field
The present invention relates to a kind of compositions with increase bone substance density improving function and preparation method thereof, belong to technical field of health care food.
Background technology
Osteoporosis is the skeletal diseases of a kind of general, is characterized in osteopenia, and the fine structure of osseous tissue is destroyed, and makes the fragility of bone increase, the dangerous increase of fracture.It can make the skeleton at any position in addition to head fracture.Due to the aging of world population, even if osteoporosis and osteopenia are also common metabolic osteopathy in developed country.Medical circle will prevent and treat osteoporosis, prevention fracture is placed on position of equal importance with treatment hyperlipidemia, prevention myocardial infarction, treatment hypertension prevention apoplexy.According to incompletely statistics, China's senile osteoporosis disease sickness rate of more than 60 years old is about 59.89%, increases bone density, effectively treatment osteoporosis and has become as the important topic of people's extensive concern.
Osteoporosis is a health problem worldwide, that increasingly attract people's attention.At present the whole world about 200,000,000 people suffers from osteoporosis, its sickness rate leapt to commonly encountered diseases, the 7th of frequently-occurring disease.Current research shows, in the osteoporosis that China is considered as the peculiar disease of old people always, actually the most exists in the Childhood.Up to now, still do not have a kind of safe and effective method to make the skeleton after loosening recover normal bone amount and structure completely, therefore improve people's understanding to osteoporosis danger, understand its pathogenic factors, strengthen early prevention and be particularly important.
Prevent or reduce the generation of primary disease, people except self health consciousness to be strengthened, make great efforts to form good living habit in addition to, take certain intervening measure just to seem the most necessary.Health food has certain health care, and safety is high, can long-term taking, the demand of people's daily health caring can be met again, therefore, exploitation increases the health food of bone density and is with a wide range of applications.This product is increasing while bone density, also can substantially reduce that current sickness rate is high, morbidity crowd is wide, have a strong impact on the risk factor of the bone loss disorders of human health and quality of life, can be greatly enhanced meaning and the value of osteoporosis early prevention.
Summary of the invention
Based on above-mentioned situation, it is an object of the invention to provide a kind of compositions having and increasing bone substance density improving function；Another purpose is to provide the preparation method of above-mentioned composition；Also reside in and provide above-mentioned composition in preparation prevention or to reduce the application in osteoporosis product.
The present invention is achieved by the following technical solutions:
A kind of have the compositions increasing bone substance density improving function, its contained active component is calcium carbonate, Glucosamine sulfate potassium chloride, chondroitin sulfate, phosphopeptide caseinate, Cortex Eucommiae extract, Rhizoma Curcumae Longae extract, by weight, the active component making said composition is: calcium carbonate 10-50 part, Glucosamine sulfate potassium chloride 10-40 part, chondroitin sulfate 1-15 part, phosphopeptide caseinate 0.5-8 part, Cortex Eucommiae extract 5-20 part, Rhizoma Curcumae Longae extract 0.1-5 part；
Preferably, by weight, calcium carbonate 20-30 part, Glucosamine sulfate potassium chloride 18-25 part, chondroitin sulfate 5-10 part, phosphopeptide caseinate 1-4 part, Cortex Eucommiae extract 8-12 part, Rhizoma Curcumae Longae extract 0.5-2 part；
Best of breed is, by weight, and calcium carbonate 25 parts, Glucosamine sulfate potassium chloride 22.5 parts, chondroitin sulfate 7.5 parts, phosphopeptide caseinate 2.5 parts, Cortex Eucommiae extract 10 parts, Rhizoma Curcumae Longae extract 1 part.
Preparation of the present invention is oral formulations；Including: hard capsule, soft capsule, granule, tablet, milk slice, sour milk tablet, colostrum sheet, chewable tablet, honeyed pill, concentration honeyed pill, water-honeyed pill, condensed water honeyed pill, oral liquid, packed medicinal tea, decoction medicinal tea, beverage, powder, saccharide, medicated wine, preserve.
Described preparation in addition to the active ingredient (s, also includes adjuvant.
The preparation technology of described preparation includes: take the calcium carbonate of described weight portion, Glucosamine sulfate potassium chloride, chondroitin sulfate, phosphopeptide caseinate, Cortex Eucommiae extract, Rhizoma Curcumae Longae extract, sieve, mixing, being not added with or add appropriate amount of auxiliary materials, technique makes the preparation accepted on pharmaceutics routinely.
The preparation method of described tablet is: take the calcium carbonate of described weight portion, Glucosamine sulfate potassium chloride, chondroitin sulfate, phosphopeptide caseinate, Cortex Eucommiae extract, Rhizoma Curcumae Longae extract, sieve respectively, add appropriate filler, be sufficiently mixed, pelletize, it is dried, granulate, adds moderate lubrication agent, mixing, tabletting, coating or not coating, obtain tablet.
Wherein, one or more during filler refers to mannitol, starch, pregelatinized Starch, dextrin, lactose, microcrystalline Cellulose, xylitol, sorbitol, erythritol；Preferably microcrystalline cellulose.Lubricant refers to one or more in magnesium stearate, micropowder silica gel, Pulvis Talci；Preferably magnesium stearate.
Consisting of of film coating agent: hypromellose, glycerol triacetate, Ponceau 4R aluminum lake, Brilliant blue aluminum lake, titanium dioxide, Pulvis Talci.
Active component of the present invention is all that commercially available or according to each active component character is prepared from, and such as, Cortex Eucommiae extract, Rhizoma Curcumae Longae extract are prepared obtaining:
Cortex Eucommiae extract: taking the Cortex Eucommiae and add water or the ethanol extraction of variable concentrations, extracting solution concentrate drying obtains crude extract；Or use further decoction and alcohol sedimentation technique, organic solvent extractionprocess, column chromatography, carbon dioxide supercritical extraction method, steam distillation one or more be used in combination suitably refine after extract；Above-mentioned crude extract or extract are Cortex Eucommiae extract；
Preferably preparation method is: taking the Cortex Eucommiae and add 4-20 times amount water or 20-95% ethanol extraction 1-4 time, each 1-3 hour, extracting solution merged, and filtered, filtrate concentration, and drying under reduced pressure is ground into fine powder, is Cortex Eucommiae extract.
Rhizoma Curcumae Longae extract: taking Rhizoma Curcumae Longae and add water or the ethanol extraction of variable concentrations, extracting solution concentrate drying obtains crude extract；Or use further decoction and alcohol sedimentation technique, organic solvent extractionprocess, column chromatography, carbon dioxide supercritical extraction method, steam distillation one or more be used in combination suitably refine after extract；Above-mentioned crude extract or extract are Rhizoma Curcumae Longae extract；
Preferably preparation method is: takes Rhizoma Curcumae Longae and adds 4-20 times amount 20-95% ethanol extraction 1-4 time, each 1-3 hour, and extracting solution merges, and filters, and decompression filtrate recycling ethanol, to without alcohol taste, drying under reduced pressure, is ground into fine powder, is Rhizoma Curcumae Longae extract.
The present composition has the function increasing bone density, for the application in preparation prevention or minimizing osteoporosis or relevant disease product.
The present invention is to analyze osteoporotic producing cause comprehensive, osteoporosis symptoms, the situation of osteoporosis crowd, and with modern pharmacology research as foundation, in conjunction with the functional characteristics prescription of the chemistry and natural product that are currently mainly applied to osteoporotic conditions, each active component is respectively provided with certain raising bone density or helps the effect of calcium absorption.
Calcium growth promoter and metabolism to maintaining human body；Maintain, adjust the regular excitation of N&M；The division of cell；The activation of enzyme；The solidification of blood；The thinking activities of Endocrine Activity and people etc. physiological function is significant.
In the active component of the composition present invention, Maalox Antacid can generate soluble calcium when neutralizing gastric acid is made blood calcium rise by intestinal absorption.Because its calcium content is high, have no side effect, be to use the optimal calcium complement agent the most extensive, calcium content is the highest, effective, price is low.
Glucosamine is a kind of natural amino monosaccharide, is present in human body particularly articular cartilage, is the base substance of synthesizing amino polysaccharide, is also the constituent of proteoglycan in articular cartilage.It can specifically act on articular cartilage, recovers the normal metabolic function of chondrocyte, stimulates chondrocyte to have the proteoglycan of normal multimeric structure, safeguards the morphosis of cartilage matrix；The generation of super oxyradical, collagenase and the phospholipase A2 of suppression damaged cartilage substrate II Collagen Type VI；The synthesis of suppression prostaglandin, protects the various harmful substances destructions to chondrocyte such as 17-hydroxy-11-dehydrocorticosterone, thus delays pathological process and the progression of disease of bone articular degeneration, improve joint motion, alleviating pain.The total trend of glucosamine drug study shows that glucosamine can improve the symptom of osteoarthritis; the metabolic activity promoting articular cartilage is strengthened; the anabolism of collagen, ammonia polyose of candy and other structural protein increases, and protection and reparation tool to articular cartilage are of great significance.
Chondroitin sulfate (CS) sodium salt and D-Glucose amine and D-galactose therapeutic alliance arthritis, can mitigation symptoms, its mechanism can remove a large amount of Na+ absorbed in synovial membrane for CS, promotes that sclerotin increases, and makes the cartilage of destruction recover normally.The CS of natural phosphatidyl ethanol amine derivative on normal articular cartilage surface can protective tissue from damage, and the PECS synthesized is used in damaged part, simulates natural CSPG effect, can suppress the formation of pannus, protects cartilaginous tissue.Chondroitin sulfate can be used for treatment early stage or moderate arthritis and non-evident effect；Illustrate that CS can promote osteoblastic hypertrophy, promote new bone formation, accelerate the process of knitting.Oral CS can alleviate OA pain and improvement knee function, reduces joint erosion progress.CS is naturally occurring composition in connective tissue, it is possible to bound water molecule is used for lubricating and supporting joint, makes joint motion freely.
Phosphopeptide caseinate (CPP) derives from the peptide chain in casein rich in phosphoserine, with calcium iron ion, there is affinity, form soluble complexes, dissolved state is kept in whole small intestine condition, the formation that can delay significantly and stop insoluble phosphate to crystallize, thus increase the absorption of the calcium of small intestinal, ferrum.
The Cortex Eucommiae is the dry bark of the Eucommiaceae plant Cortex Eucommiae, is Chinese famous and precious tonic herb.Its sweet in the mouth, warm in nature.Having liver and kidney tonifying, bone and muscle strengthening, Chong and Ren Meridians regulating, solid through antiabortive effect, cure mainly spinal column ache, foot and knee flaccidity, dribbling urination, uncontrolled urination itches, and vaginal bleeding during pregnancy is intended to fall, frequent fetal movement, hypertension.Modern study finds, the Cortex Eucommiae has rubbish in purged body, strengthens human body cell substance metabolism, prevents muscle skeleton aging, balanced human's blood pressure, decomposer inner cholesterol, reduces body fat, recovers blood vessel elasticity, diuresis heat clearing away, broad-spectrum antiseptic, stimulating central nervous system, improves leukocyte pharmacological action.
Rhizoma Curcumae Longae is the rhizome of zingiberaceous plant Rhizoma Curcumae Longae or Radix Curcumae, and its acrid in the mouth, hardship are warm in nature, enter spleen, Liver Channel.There is removing blood stasis, circulation of qi promoting, stimulate the menstrual flow, effect of pain relieving, cure mainly trusted subordinate's feeling of fullness distending pain, brachialgia, abdominal mass, women's blood stasis amenorrhea, puerperal, the stasis of blood stopped stomachache, injury from falling down, carbuncle.The effects such as modern study shows, Rhizoma Curcumae Longae has blood fat reducing, antitumor, antiinflammatory, resisting pathogenic microbes, reduces blood and plasma viscosity, increases generation and the secretion of bile, promotes gallbladder contraction, antioxidation.
In sum, inventive compound improves bone density with the use of having or helps the theoretical foundation of calcium absorption fully, can improve the human body absorption to calcium, increase bone density, and energy liver and kidney tonifying, blood pressure lowering, blood fat reducing, can be applicable to the diseases such as the loss of male's ossein, osteoporosis.The present invention adds the Cortex Eucommiae, Rhizoma Curcumae Longae while Bone Mineral Density in Male increasing, further liver and kidney tonifying, bone and muscle strengthening, more can benefiting QI for activating blood circulation, reduce " three high " etc., this is the place of creativeness of the present invention, be in the product of existing increase bone density without reference to.Separately showing through pharmacological toxicology research, this compositions is safe and reliable, is improved effect of bone density, with strong points, effective.
The beneficial effect of the present composition is described below by way of experimental example:
Experimental example:
1, main material
Animal: cleaning grade Wistar female rats, body weight 249-299g.
Feedstuff: see " increasing bone substance density improving function experimental technique " preparation in Ministry of Public Health " health food inspection and assessment technique specification " (version in 2003).
Medicine: medicine group 1(prepares according to the embodiment of the present invention 1)；
Medicine group 2(prepares according to the embodiment of the present invention 2)；
Medicine group 3(prepares according to the embodiment of the present invention 3).
2, method and result
First anaesthetize through rats by intraperitoneal injection 50mg/kgBW Nembutal sodium solution, after middle hypogastric region unhairing iodine tincture and ethanol carry out partly sterilised, do about 1cm otch along stomach wall median line and rat is implemented castration operation, extract bilateral ovaries；Separately take one group of rat operation and ibid but do not extract bilateral ovaries, make Sham-operated control group.
Postoperative animal is randomly divided into medicine group 1, medicine group 2, medicine group 3, castration model control group (ovary excision+solvent), positive controls (calcium carbonate) according to body weight；Separately set sham-operation negative control group；Often 10 animal list cages of group are raised.Medicine group gives the corresponding present composition, sham-operation negative control and castration model control group (ovary excision+solvent) by design dosage with 1ml/100gBW per os gavage and gives calcium carbonate with aliquots of deionized water gavage, positive controls (calcium carbonate).All experiments animal all drinks deionized water, weighs weekly once, 12 weeks experimental periods.
Animal feeding is sacrificed by decapitation after 12 weeks, separate right side femur, 105 baking ovens dry to constant weight, weigh bone weight, use bone mineral measuring instrument, measure rat femur midpoint and the bone density of femur distal end, use wet digesting, with Hitachi Z-2000 atomic absorption spectroscopy determination femur calcium content, result is shown in 1-2.
Table
1
The present composition is on rat femur weight and the impact of calcium content of bone
(
±
s)
* compared with castration model control group, P < 0.05
# compared with positive controls, P < 0.05
From table 1, Sham-operated control group compares with castration model control group, and unit femur calcium content is apparently higher than castration model control group, and difference has significance (P < 0.05), and modeling success is described；Medicine group compares with castration model control group, and unit femur calcium content is significantly higher than castration model control group rat (P < 0.05)；Medicine group compares with positive controls, and unit femur calcium content is significantly higher than positive controls rat (P < 0.05).
Table
2
The present composition respectively organizes rat bone density and femur length compares
(
±
SD)
* compared with castration model control group, P < 0.05
# compared with positive controls, P < 0.05
From table 2, medicine group of the present invention compares with castration model control group, and femur distal end bone density value, femur midpoint bone density value are above castration model control group (P < 0.05)；Femur length present composition medicine group and castration model control group comparing difference are without significance；Medicine group of the present invention compares with positive controls, and femur distal end bone density value, femur midpoint bone density value are above positive controls (P < 0.05).
Embodiment of the present invention 4-18 has carried out similar test the most according to the method described above, and result is identical with the above results.
3, conclusion
After the rat oral gavage present composition, compare with castration model control group, unit femur calcium content, femur distal end bone density value, femur midpoint bone density value can be dramatically increased；Comparing with positive controls, also can dramatically increase unit femur calcium content, femur distal end bone density value, femur midpoint bone density value, and difference all has significant (P ＜ 0.05).The prompting present composition has the effect increasing bone substance density improving function.
Specific embodiment
The preparation method of of the present invention compositions is expanded on further by the following examples.
Embodiment 1
Calcium carbonate 250g, Glucosamine sulfate potassium chloride 225g, chondroitin sulfate 75g, phosphopeptide caseinate 25g, Cortex Eucommiae extract 100g, Rhizoma Curcumae Longae extract 10g
Take the calcium carbonate of recipe quantity, Glucosamine sulfate potassium chloride, chondroitin sulfate, phosphopeptide caseinate, Cortex Eucommiae extract, Rhizoma Curcumae Longae extract, cross 80 mesh sieves respectively, add appropriate microcrystalline Cellulose, be sufficiently mixed, ethanol solution is pelletized, it is dried, granulate, adds appropriate magnesium stearate, mixing, tabletting, coating, obtain tablet.
Wherein the consisting of of film coating agent: hypromellose, glycerol triacetate, Ponceau 4R aluminum lake, Brilliant blue aluminum lake, titanium dioxide, Pulvis Talci.
Embodiment 2
Calcium carbonate 100g, Glucosamine sulfate potassium chloride 400g, chondroitin sulfate 10g, phosphopeptide caseinate 80g, Cortex Eucommiae extract 50g, Rhizoma Curcumae Longae extract 50g
Take the calcium carbonate of recipe quantity, Glucosamine sulfate potassium chloride, chondroitin sulfate, phosphopeptide caseinate, Cortex Eucommiae extract, Rhizoma Curcumae Longae extract, cross 80 mesh sieves respectively, add appropriate microcrystalline Cellulose, be sufficiently mixed, ethanol solution is pelletized, it is dried, granulate, adds appropriate magnesium stearate, mixing, tabletting, coating, obtain tablet.
Wherein the consisting of of film coating agent: hypromellose, glycerol triacetate, Ponceau 4R aluminum lake, Brilliant blue aluminum lake, titanium dioxide, Pulvis Talci.
Embodiment 3
Calcium carbonate 500g, Glucosamine sulfate potassium chloride 100g, chondroitin sulfate 150g, phosphopeptide caseinate 5g, Cortex Eucommiae extract 200g, Rhizoma Curcumae Longae extract 1g
Take the calcium carbonate of recipe quantity, Glucosamine sulfate potassium chloride, chondroitin sulfate, phosphopeptide caseinate, Cortex Eucommiae extract, Rhizoma Curcumae Longae extract, cross 80 mesh sieves respectively, add appropriate microcrystalline Cellulose, be sufficiently mixed, ethanol solution is pelletized, it is dried, granulate, adds appropriate magnesium stearate, mixing, tabletting, coating, obtain tablet.
Wherein the consisting of of film coating agent: hypromellose, glycerol triacetate, Ponceau 4R aluminum lake, Brilliant blue aluminum lake, titanium dioxide, Pulvis Talci.
Embodiment 4
Calcium carbonate 200g, Glucosamine sulfate potassium chloride 250g, chondroitin sulfate 50g, phosphopeptide caseinate 40g, Cortex Eucommiae extract 80g, Rhizoma Curcumae Longae extract 20g
Take the calcium carbonate of recipe quantity, Glucosamine sulfate potassium chloride, chondroitin sulfate, phosphopeptide caseinate, Cortex Eucommiae extract, Rhizoma Curcumae Longae extract, sieve respectively, add appropriate dextrin, pregelatinized Starch, be sufficiently mixed, ethanol solution is pelletized, it is dried, granulate, adds appropriate magnesium stearate, mixing, tabletting, coating, obtain tablet.
Wherein the consisting of of film coating agent: hypromellose, glycerol triacetate, Ponceau 4R aluminum lake, Brilliant blue aluminum lake, titanium dioxide, Pulvis Talci.
Embodiment 5
Calcium carbonate 300g, Glucosamine sulfate potassium chloride 180g, chondroitin sulfate 100g, phosphopeptide caseinate 10g, Cortex Eucommiae extract 120g, Rhizoma Curcumae Longae extract 5g
Take the calcium carbonate of recipe quantity, Glucosamine sulfate potassium chloride, chondroitin sulfate, phosphopeptide caseinate, Cortex Eucommiae extract, Rhizoma Curcumae Longae extract, sieve respectively, add appropriate amount of starch, mannitol, be sufficiently mixed, ethanol solution is pelletized, it is dried, granulate, adds appropriate magnesium stearate, mixing, tabletting, coating, obtain tablet.
Wherein the consisting of of film coating agent: hypromellose, glycerol triacetate, Ponceau 4R aluminum lake, Brilliant blue aluminum lake, titanium dioxide, Pulvis Talci.
Embodiment 6
Calcium carbonate 260g, Glucosamine sulfate potassium chloride 200g, chondroitin sulfate 70g, phosphopeptide caseinate 30g, Cortex Eucommiae extract 80g, Rhizoma Curcumae Longae extract 12g
Take the calcium carbonate of recipe quantity, Glucosamine sulfate potassium chloride, chondroitin sulfate, phosphopeptide caseinate, Cortex Eucommiae extract, Rhizoma Curcumae Longae extract, sieve respectively, adding appropriate pregelatinized Starch, lactose, dextrin, be sufficiently mixed, ethanol solution is pelletized, it is dried, granulate, adds appropriate micropowder silica gel, Pulvis Talci, mixing, tabletting, obtains tablet.
Embodiment 7
Calcium carbonate 250g, Glucosamine sulfate potassium chloride 225g, chondroitin sulfate 75g, phosphopeptide caseinate 25g, Cortex Eucommiae extract 100g, Rhizoma Curcumae Longae extract 10g
Take the calcium carbonate of recipe quantity, Glucosamine sulfate potassium chloride, chondroitin sulfate, phosphopeptide caseinate, Cortex Eucommiae extract, Rhizoma Curcumae Longae extract, sieve respectively, add appropriate mannitol, lactose, mixing, alcohol granulation, it is dried, granulate, obtains granule.
Embodiment 8
Calcium carbonate 240g, Glucosamine sulfate potassium chloride 220g, chondroitin sulfate 80g, phosphopeptide caseinate 30g, Cortex Eucommiae extract 110g, Rhizoma Curcumae Longae extract 15g
Take the calcium carbonate of recipe quantity, Glucosamine sulfate potassium chloride, chondroitin sulfate, phosphopeptide caseinate, Cortex Eucommiae extract, Rhizoma Curcumae Longae extract, sieve respectively, add appropriate pregelatinized Starch, aspartame, mixing, adds micropowder silica gel, mixing, pelletizes, it is dried, granulate, obtains granule.
Embodiment 9
Calcium carbonate 150g, Glucosamine sulfate potassium chloride 350g, chondroitin sulfate 20g, phosphopeptide caseinate 70g, Cortex Eucommiae extract 60g, Rhizoma Curcumae Longae extract 40g
Take the calcium carbonate of recipe quantity, Glucosamine sulfate potassium chloride, chondroitin sulfate, phosphopeptide caseinate, Cortex Eucommiae extract, Rhizoma Curcumae Longae extract, sieve respectively, add appropriate mannitol, aspartame, mixing, pelletize, be dried, tabletting, obtain chewable tablet.
Embodiment 10
Calcium carbonate 450g, Glucosamine sulfate potassium chloride 150g, chondroitin sulfate 140g, phosphopeptide caseinate 6g, Cortex Eucommiae extract 150g, Rhizoma Curcumae Longae extract 2g
Taking the calcium carbonate of recipe quantity, Glucosamine sulfate potassium chloride, chondroitin sulfate, phosphopeptide caseinate, Cortex Eucommiae extract, Rhizoma Curcumae Longae extract, sieve respectively, add appropriate amount of auxiliary materials, conventional method makes capsule.
Embodiment 11
Calcium carbonate 220g, Glucosamine sulfate potassium chloride 230g, chondroitin sulfate 60g, phosphopeptide caseinate 40g, Cortex Eucommiae extract 90g, Rhizoma Curcumae Longae extract 11g
Taking the calcium carbonate of recipe quantity, Glucosamine sulfate potassium chloride, chondroitin sulfate, phosphopeptide caseinate, Cortex Eucommiae extract, Rhizoma Curcumae Longae extract, sieve respectively, add appropriate amount of auxiliary materials, conventional method makes milk slice.
Embodiment 12
Calcium carbonate 260g, Glucosamine sulfate potassium chloride 230g, chondroitin sulfate 60g, phosphopeptide caseinate 20g, Cortex Eucommiae extract 90g, Rhizoma Curcumae Longae extract 9g
Taking the calcium carbonate of recipe quantity, Glucosamine sulfate potassium chloride, chondroitin sulfate, phosphopeptide caseinate, Cortex Eucommiae extract, Rhizoma Curcumae Longae extract, sieve respectively, add appropriate amount of auxiliary materials, conventional method makes pill.
Embodiment 13
Calcium carbonate 240g, Glucosamine sulfate potassium chloride 220g, chondroitin sulfate 80g, phosphopeptide caseinate 30g, Cortex Eucommiae extract 110g, Rhizoma Curcumae Longae extract 15g
Taking the calcium carbonate of recipe quantity, Glucosamine sulfate potassium chloride, chondroitin sulfate, phosphopeptide caseinate, Cortex Eucommiae extract, Rhizoma Curcumae Longae extract, sieve respectively, add appropriate amount of auxiliary materials, conventional method makes packed medicinal tea.
Embodiment 14
Calcium carbonate 350g, Glucosamine sulfate potassium chloride 160g, chondroitin sulfate 120g, phosphopeptide caseinate 20g, Cortex Eucommiae extract 150g, Rhizoma Curcumae Longae extract 4g
Taking the calcium carbonate of recipe quantity, Glucosamine sulfate potassium chloride, chondroitin sulfate, phosphopeptide caseinate, Cortex Eucommiae extract, Rhizoma Curcumae Longae extract, sieve respectively, add appropriate amount of auxiliary materials, conventional method makes oral liquid.
Embodiment 15
Calcium carbonate 250g, Glucosamine sulfate potassium chloride 225g, chondroitin sulfate 75g, phosphopeptide caseinate 25g, Cortex Eucommiae extract 100g, Rhizoma Curcumae Longae extract 10g
Take the calcium carbonate of recipe quantity, Glucosamine sulfate potassium chloride, chondroitin sulfate, phosphopeptide caseinate, Cortex Eucommiae extract, Rhizoma Curcumae Longae extract, cross 80 mesh sieves respectively, add appropriate microcrystalline Cellulose, xylitol, be sufficiently mixed, ethanol solution is pelletized, it is dried, granulate, adds appropriate magnesium stearate, mixing, tabletting, coating, obtain tablet.
Wherein the consisting of of film coating agent: hypromellose, glycerol triacetate, Ponceau 4R aluminum lake, Brilliant blue aluminum lake, titanium dioxide, Pulvis Talci.
Embodiment 16
Calcium carbonate 100g, Glucosamine sulfate potassium chloride 400g, chondroitin sulfate 10g, phosphopeptide caseinate 80g, Cortex Eucommiae extract 50g, Rhizoma Curcumae Longae extract 50g
Take the calcium carbonate of recipe quantity, Glucosamine sulfate potassium chloride, chondroitin sulfate, phosphopeptide caseinate, Cortex Eucommiae extract, Rhizoma Curcumae Longae extract, cross 80 mesh sieves respectively, add appropriate sorbitol, erythritol, lactose, be sufficiently mixed, ethanol solution is pelletized, it is dried, granulate, adds appropriate magnesium stearate, mixing, tabletting, coating, obtain tablet.
Wherein the consisting of of film coating agent: hypromellose, glycerol triacetate, Ponceau 4R aluminum lake, Brilliant blue aluminum lake, titanium dioxide, Pulvis Talci.
Embodiment 17
Calcium carbonate 500g, Glucosamine sulfate potassium chloride 100g, chondroitin sulfate 150g, phosphopeptide caseinate 5g, Cortex Eucommiae extract 200g, Rhizoma Curcumae Longae extract 1g
Take the calcium carbonate of recipe quantity, Glucosamine sulfate potassium chloride, chondroitin sulfate, phosphopeptide caseinate, Cortex Eucommiae extract, Rhizoma Curcumae Longae extract, cross 80 mesh sieves respectively, add appropriate microcrystalline Cellulose, sorbitol, be sufficiently mixed, 60% ethanol solution is pelletized, it is dried, granulate, adds appropriate magnesium stearate, mixing, tabletting, coating, obtain tablet.
Embodiment 18
Calcium carbonate 250g, Glucosamine sulfate potassium chloride 225g, chondroitin sulfate 75g, phosphopeptide caseinate 25g, Cortex Eucommiae extract 100g, Rhizoma Curcumae Longae extract 10g
Taking the calcium carbonate of recipe quantity, Glucosamine sulfate potassium chloride, chondroitin sulfate, phosphopeptide caseinate, Cortex Eucommiae extract, Rhizoma Curcumae Longae extract, cross 80 mesh sieves respectively, be sufficiently mixed, ethanol solution is pelletized, it is dried, granulate, adds appropriate magnesium stearate, mixing, tabletting, coating, obtain tablet.
Cortex Eucommiae extract in above example 1-18, Rhizoma Curcumae Longae extract can be prepared obtaining:
Cortex Eucommiae extract: taking the Cortex Eucommiae and add water or the ethanol extraction of variable concentrations, extracting solution concentrate drying obtains crude extract；Or use further decoction and alcohol sedimentation technique, organic solvent extractionprocess, column chromatography, carbon dioxide supercritical extraction method, steam distillation one or more be used in combination suitably refine after extract；Above-mentioned crude extract or extract are Cortex Eucommiae extract；
Preferably preparation method is: taking the Cortex Eucommiae and add 4-20 times amount water or 20-95% ethanol extraction 1-4 time, each 1-3 hour, extracting solution merged, and filtered, and decompression filtrate recycling ethanol, extremely without alcohol taste, drying under reduced pressure, is ground into fine powder, is Cortex Eucommiae extract.
Rhizoma Curcumae Longae extract: taking Rhizoma Curcumae Longae and add water or the ethanol extraction of variable concentrations, extracting solution concentrate drying obtains crude extract；Or use further decoction and alcohol sedimentation technique, organic solvent extractionprocess, column chromatography, carbon dioxide supercritical extraction method, steam distillation one or more be used in combination suitably refine after extract；Above-mentioned crude extract or extract are Rhizoma Curcumae Longae extract；
Preferably preparation method is: takes Rhizoma Curcumae Longae and adds 4-20 times amount 20-95% ethanol extraction 1-4 time, each 1-3 hour, and extracting solution merges, and filters, and decompression filtrate recycling ethanol, to without alcohol taste, drying under reduced pressure, is ground into fine powder, is Rhizoma Curcumae Longae extract.
Or, calcium carbonate, Glucosamine sulfate potassium chloride, chondroitin sulfate, phosphopeptide caseinate, Cortex Eucommiae extract, Rhizoma Curcumae Longae extract are obtained by buying commercially available product.
Claims (11)
1. one kind has the compositions increasing bone substance density improving function, it is characterized in that, it is made up of the component of following weight portion: calcium carbonate 10-50 part, Glucosamine sulfate potassium chloride 10-40 part, chondroitin sulfate 1-15 part, phosphopeptide caseinate 0.5-8 part, Cortex Eucommiae extract 5-20 part, Rhizoma Curcumae Longae extract 0.1-5 part.
Compositions the most according to claim 1, it is characterized in that, it is made up of the component of following weight portion: calcium carbonate 20-30 part, Glucosamine sulfate potassium chloride 18-25 part, chondroitin sulfate 5-10 part, phosphopeptide caseinate 1-4 part, Cortex Eucommiae extract 8-12 part, Rhizoma Curcumae Longae extract 0.5-2 part.
3. the preparation method of compositions described in claim 1 or 2, it is characterised in that it is prepared:
Take the calcium carbonate of described weight portion, Glucosamine sulfate potassium chloride, chondroitin sulfate, phosphopeptide caseinate, Cortex Eucommiae extract, Rhizoma Curcumae Longae extract, sieve, mixing, it is not added with or adds appropriate amount of auxiliary materials, technique makes the preparation accepted on pharmaceutics routinely.
Preparation method the most according to claim 3, it is characterised in that described preparation refers to oral formulations.
Preparation method the most according to claim 4, it is characterised in that described oral formulations refers to tablet, capsule, granule, pill, oral liquid, packed medicinal tea.
Preparation method the most according to claim 3, it is characterised in that tablet is prepared:
Take the calcium carbonate of described weight portion, Glucosamine sulfate potassium chloride, chondroitin sulfate, phosphopeptide caseinate, Cortex Eucommiae extract, Rhizoma Curcumae Longae extract, sieve respectively, add appropriate filler, be sufficiently mixed, pelletize, it is dried, granulate, adds moderate lubrication agent, mixing, tabletting, coating or not coating, obtain tablet.
Preparation method the most according to claim 6, it is characterised in that described filler refers to one or more in mannitol, starch, pregelatinized Starch, dextrin, lactose, microcrystalline Cellulose, xylitol, sorbitol, erythritol；Lubricant refers to one or more in magnesium stearate, micropowder silica gel, Pulvis Talci.
Compositions the most according to claim 1 and 2, it is characterised in that described Cortex Eucommiae extract, Rhizoma Curcumae Longae extract are prepared obtaining:
Cortex Eucommiae extract: taking the Cortex Eucommiae and add water or the ethanol extraction of variable concentrations, extracting solution concentrate drying obtains crude extract；Or use further decoction and alcohol sedimentation technique, organic solvent extractionprocess, column chromatography, carbon dioxide supercritical extraction method, steam distillation one or more be used in combination suitably refine after extract；Above-mentioned crude extract or extract are Cortex Eucommiae extract；
Rhizoma Curcumae Longae extract: taking Rhizoma Curcumae Longae and add water or the ethanol extraction of variable concentrations, extracting solution concentrate drying obtains crude extract；Or use further decoction and alcohol sedimentation technique, organic solvent extractionprocess, column chromatography, carbon dioxide supercritical extraction method, steam distillation one or more be used in combination suitably refine after extract；Above-mentioned crude extract or extract are Rhizoma Curcumae Longae extract.
Compositions the most according to claim 8, it is characterised in that described Cortex Eucommiae extract, Rhizoma Curcumae Longae extract are prepared obtaining:
Cortex Eucommiae extract: taking the Cortex Eucommiae and add 4-20 times amount water or 20-95% ethanol extraction 1-4 time, each 1-3 hour, extracting solution merged, and filtered, and filtrate concentrates, and drying under reduced pressure is ground into fine powder, is Cortex Eucommiae extract；
Rhizoma Curcumae Longae extract: take Rhizoma Curcumae Longae and add 4-20 times amount 20-95% ethanol extraction 1-4 time, each 1-3 hour, extracting solution merged, and filtered, and decompression filtrate recycling ethanol, to without alcohol taste, drying under reduced pressure, is ground into fine powder, is Rhizoma Curcumae Longae extract.
Compositions the most according to claim 1 and 2, it is characterised in that described calcium carbonate, Glucosamine sulfate potassium chloride, chondroitin sulfate, phosphopeptide caseinate, Cortex Eucommiae extract, Rhizoma Curcumae Longae extract all obtain by buying commercially available product.
Compositions described in 11. claim 1 or 2 is for preparing the application in the health food increasing bone density.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN118415341A (en) * | 2024-06-27 | 2024-08-02 | 朗姿赛尔生物科技（广州）有限公司 | Composition for increasing bone mineral density, health food and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101559218A (en) * | 2009-02-16 | 2009-10-21 | 北京因科瑞斯医药科技有限公司 | Composition with function of increasing bone density |
| CN103721242A (en) * | 2014-01-20 | 2014-04-16 | 庞会心 | New application of pharmaceutical composition in prevention or treatment of osteoporosis |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101559218A (en) * | 2009-02-16 | 2009-10-21 | 北京因科瑞斯医药科技有限公司 | Composition with function of increasing bone density |
| CN103721242A (en) * | 2014-01-20 | 2014-04-16 | 庞会心 | New application of pharmaceutical composition in prevention or treatment of osteoporosis |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN118415341A (en) * | 2024-06-27 | 2024-08-02 | 朗姿赛尔生物科技（广州）有限公司 | Composition for increasing bone mineral density, health food and preparation method thereof |
| CN118415341B (en) * | 2024-06-27 | 2024-09-17 | 朗姿赛尔生物科技（广州）有限公司 | Composition for increasing bone mineral density and preparation method thereof |
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