CN106053121B - Integrate the device of sampling, reaction, detection - Google Patents
Integrate the device of sampling, reaction, detection Download PDFInfo
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- CN106053121B CN106053121B CN201610480687.2A CN201610480687A CN106053121B CN 106053121 B CN106053121 B CN 106053121B CN 201610480687 A CN201610480687 A CN 201610480687A CN 106053121 B CN106053121 B CN 106053121B
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- liquid
- separatnig valve
- sampling
- storage pipe
- liquid storage
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/02—Devices for withdrawing samples
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
- G01N21/78—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Plasma & Fusion (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
The invention discloses two kinds of devices for integrating sampling, reaction, detection, the first device includes liquid storage pipe, liquid separatnig valve, fixinig plate, sampling wiper sub bar and reaction tube, and liquid separatnig valve is equipped with broken needle；Fixinig plate connects sampling wiper sub bar；Liquid separatnig valve is packed into liquid storage tube cavity, and the storage chamber that liquid storage pipe and liquid separatnig valve are formed is provided with solution, and the needle of liquid separatnig valve is located in storage chamber；Fixinig plate is packed into liquid storage pipe, and gap is equipped between liquid separatnig valve, places chemical substance in gap；The open end of liquid storage pipe puts on reaction tube.Second device includes all elements of the first device, simultaneously containing can damaged ampoul tube, the needle of liquid separatnig valve is located at outside storage chamber.Plurality of reagents subregion is placed, is used in mixed way before reaction by the configuration of the present invention is simple, can be continuously finished acquisition, processing, reaction and the detecting step of sample.It can be widely applied to Pathogen test, microculture, biochemical enzyme activity assay, the immunochemistry detection etc. of clinical sample.
Description
Technical field
The present invention relates to chemical devices, more particularly to the device for integrating sampling, reaction, detection.
Background technique
Medical science is related to two parts, i.e. sample acquisition and detection.It samples and detects due to a lack of effective collection
The reaction unit being integrated, the two above steps are carried out separately at present.Meanwhile the confidence level of testing result depend on and
When effectively handle sample, thus integral type integrate sampling, reaction and detection device, can locate in sampling location
Sample is managed, it is not only time saving to be also correspondingly improved accuracy in detection.
The Chinese invention patent of Patent No. ZL200510023792.5 discloses a kind of device of sample collecting and testing, should
In device containing can damaged valve, can the needle of damaged valve be located in reservoir solution.Meanwhile can damaged valve valve body and sampling wiper
Careful pipe is connected (insertion of the front end of sampling swab tubule can the needle and valve body of damaged valve between), forms an entirety.Valve
Before needle does not fracture, liquid cannot be introduced into the inner cavity of sampling swab.The construction of the device leads to that a kind of examination can only be housed in liquid storage pipe
Agent may not apply to the integrated device of plurality of reagents reaction, using there is certain limitation.
Summary of the invention
Integrate sampling, reaction, the device detected the technical problem to be solved in the present invention is that providing, which can be with
Integrated device applied to plurality of reagents reaction.The apparatus structure is simple, easy to operate, can handle sample in sampling location
Product, it is not only time saving to be also correspondingly improved accuracy in detection.
In order to solve the above technical problems, the invention provides the following technical scheme:
In one aspect of the invention, a kind of device for integrating sampling, reaction, detection is provided, which includes: liquid storage
Pipe, liquid separatnig valve, fixinig plate, sampling wiper sub bar, reaction tube；Liquid separatnig valve is equipped with broken needle；Fixinig plate connects sampling wiper
Sub bar；Liquid separatnig valve is packed into liquid storage tube cavity, and the storage chamber that liquid storage pipe and liquid separatnig valve are formed is provided with solution, the needle position of liquid separatnig valve
In in the storage chamber；Fixinig plate is packed into liquid storage pipe, and gap is equipped between liquid separatnig valve, places chemical substance in gap；Storage
The open end of liquid pipe puts on reaction tube.
Preferably, porous membrane is additionally provided in the gap.
Preferably, one end of the sampling wiper sub bar is equipped with aseptic cotton carrier, oese or spiral sampling cone, other end insertion
In the cavity of fixinig plate.
Preferably, the liquid storage pipe is made of clear supple material；The reaction tube is flexible transparent flexible pipe
Body.
Preferably, the tail end of the reaction tube is equipped with the adapter with snap bar, and sets housing pipe sleeve outside adapter；
The adapter cavity is hollow, and snap bar is solid.The snap bar for breaking the adapter of the tail end of disconnected reaction tube, takes out reaction tube
Outer tube, the outer wall of extruding reaction pipe, liquid are flowed out from adapter port, ooze detection after can be used for reactant mixing.
In one aspect of the invention, another device for integrating sampling, reaction, detection is provided, which includes: storage
Liquid pipe, can damaged ampoul tube, liquid separatnig valve, fixinig plate, sampling wiper sub bar, reaction tube；Liquid separatnig valve is equipped with broken needle；Gu
Stator connects sampling wiper sub bar；Liquid separatnig valve is packed into liquid storage bottom of the tube, and the storage chamber that liquid storage pipe and liquid separatnig valve are formed is provided with solution,
The needle of liquid separatnig valve is located at outside the storage chamber；It is described can damaged ampoul tube be preinstalled with chemical substance, and be packed into the storage chamber
It is interior；Fixinig plate is packed into liquid storage pipe, and gap is equipped between liquid separatnig valve, places chemical substance in gap；The open end of liquid storage pipe
Put on reaction tube.
Preferably, porous membrane is additionally provided in the gap.
Preferably, in the sampling wiper sub bar insertion fixinig plate, fixinig plate is packed into liquid storage tube cavity.
Preferably, one end of the sampling wiper sub bar is equipped with aseptic cotton carrier, oese or spiral sampling cone, other end insertion
In the cavity of fixinig plate.
Preferably, the liquid storage pipe is made of clear supple material；The reaction tube is flexible transparent flexible pipe
Body.
Preferably, the tail end of the reaction tube is equipped with the adapter with snap bar, and sets housing pipe sleeve outside adapter；
The adapter cavity is hollow, and snap bar is solid.The snap bar for breaking the adapter of disconnected reaction tube tail end takes out the outer of reaction tube
Casing, the outer wall of extruding reaction pipe, liquid are flowed out from adapter port, ooze detection after can be used for reactant mixing.
It is described can damaged ampoul tube can be one or more, it is preferably several.
It in the gap and filled chemical substance can be liquid in damaged ampoul tube, be also possible to solid.
The first device, liquid separatnig valve in liquid storage pipe are two parts separated with sampling wiper sub bar, are separated between the two
Gap.The advantage in the gap is to play the role of another storage chamber, divides liquid storage pipe inner region to store two simultaneously
Kind or more different reagents.In addition, can also place porous membrane in the gap, powdered chemical reagent is trapped in gap
It is interior, or filter saturated solution before flowing through sampling wiper sub bar, swab handle cavity will not be blocked.And the patent No.
Used in ZL200510023792.5 be linked to be it is whole can damaged valve and sampling swab tubule be unable to reach the effect.
The difference of second device and the first device be to increase can damaged ampoul tube, and the position of the needle of liquid separatnig valve
Set difference.It is located at different in the storage chamber that liquid storage pipe and liquid separatnig valve are formed, second of dress from the needle of the first device liquid separatnig valve
The needle for the liquid separatnig valve in liquid storage pipe set is located at the outside for the storage chamber solution that liquid storage pipe and liquid separatnig valve are formed, while liquid separatnig valve
It is two parts separated with sampling wiper sub bar, there are certain gaps in liquid storage pipe for the two.In addition, liquid separatnig valve and liquid storage pipe
Ampoul tube that can be damaged is placed in the storage chamber of formation, ampoul tube is provided with another chemical substance.The advantage of the design
Be: (1) liquid storage pipe can accommodate at least three kinds of above different reagents and (be placed with No. 1 reactive material in ampoul tube, store up
No. 2 reaction solutions are filled in the storage chamber that liquid pipe and liquid separatnig valve are formed, liquid separatnig valve is packed into liquid storage pipe, and needle is located at liquid storage pipe liquid
Outside body, closed system is formed.Fixinig plate fixed sample swab thin bar, be packed into liquid storage pipe in, and with liquid separatnig valve have it is certain between
Gap is placed with No. 3 reactive materials in gap).It is retained separately especially suitable for needs unstable after mixing, could be mixed before reaction
The reagent of conjunction.(2) needle of liquid separatnig valve is located at the outside of storage chamber solution, gives the space that ampoul tube is placed in storage chamber, together
When not will receive the obstruction of snap bar when racking ampoul tube, avoid and accidentally needle fracture during racking ampoul tube, it is premature
Discharge the liquid in liquid storage pipe.The effect that the device reaches is that patent No. ZL200510023792.5 cannot achieve.
Compared with prior art, the beneficial effects of the present invention are: the configuration of the present invention is simple is given plurality of reagents subregion and is put
The space set remixes use before reaction, can be continuously finished acquisition, processing, reaction and the detecting step of sample, greatly avoid
Sample contamination, it is easy to operate.Apparatus of the present invention can be widely applied to the Pathogen test of clinical sample, microculture, biochemical enzymes
The fields such as activity analysis, immunochemistry detection.
Detailed description of the invention
Fig. 1 is the basic structure schematic diagram of apparatus of the present invention；Wherein, Fig. 1 a is the structural schematic diagram of liquid storage pipe, and Fig. 1 b is
The structural schematic diagram of ampoul tube, Fig. 1 c are the structural schematic diagrams of liquid separatnig valve, and Fig. 1 d is the structural schematic diagram of porous membrane, and Fig. 1 e is
The structural schematic diagram of sampling wiper sub bar fixinig plate, Fig. 1 f are the structural schematic diagrams of sampling wiper sub bar, and Fig. 1 g is the structure of reaction tube
Schematic diagram, Fig. 1 h are the structural schematic diagrams of 1 device of the embodiment of the present invention, and Fig. 1 i is the structural representation of 2 device of the embodiment of the present invention
Figure；
Fig. 2 is that the tail end of reaction tube of the present invention is connected with the apparatus structure schematic diagram (effect: anti-of the adapter with snap bar
Detection is oozed after answering object to mix)；Wherein, Fig. 2 a is the structural schematic diagram of 3 device of embodiment, and Fig. 2 b is the knot of 4 device of embodiment
Structure schematic diagram.
The reference numerals are as follows in figure:
1 is liquid storage pipe, and 2 be ampoul tube, and 3 be ampoul tube lid, and 4 be liquid separatnig valve, and 5 be needle, and 6 be porous membrane, and 7 be sampling
Swab handle fixinig plate, 8 be sampling wiper sub bar, and 9 be sampling wiper sub bar hole, and 10 be reaction tube, and 11 be adapter, and 12 be to fracture
Bar, 13 be outer tube, and A is gap, and B is cotton head.
Specific embodiment:
The present invention is described in detail with reference to the accompanying drawings and examples:
The embodiment of the present invention 1: the chromogenic reaction of enzyme-to-substrate
As shown in figure 1h, 1 device of the present embodiment can be applied to the chromogenic reaction of enzyme-to-substrate.Before reaction, enzyme-to-substrate is needed
It is retained separately, is mixed in reaction.Meanwhile in some cases, unstable under the substrate liquid of certain enzymes is often warm, but it is solid
State (powdered) can stable preservation at normal temperature.At this point, being placed in the storage chamber that liquid separatnig valve 4 and liquid storage pipe 1 are formed slow containing enzyme
Fliud flushing, and liquid separatnig valve 4 then places the corresponding substrate (powdered or solid-state) of enzyme with the gap A of sampling wiper sub bar fixinig plate 7, is used in combination
Porous membrane 6 separates (porous membrane 6 is located in the A of gap, is close to 8 fixinig plate 7 of sampling wiper sub bar, sees Fig. 1 h), prevents substrate from falling
Enter in sampling wiper sub bar 8.In use, the junction of rotation liquid storage pipe 1 and reaction tube 10, takes out sampling wiper sub bar 8 and samples, it will
The cotton head B of sampling wiper sub bar 8 acquires sample.Sample acquisition terminates, and sampling wiper sub bar 8 is turned back to (sampling swab in reaction tube 10
The cotton head B of bar 8 protrudes into the inner cavity of reaction tube 10 and is located at 10 bottom of reaction tube) and entangle firm and screw with liquid storage pipe 1.Break disconnected liquid separatnig valve 4
Needle 5, squeeze 1 outer wall of liquid storage pipe, enzyme buffer liquid flow into liquid separatnig valve 4 valve chamber and sampling wiper sub bar fixinig plate 7 between
It is mixed in gap A with zymolyte, then repeatedly squeezes 1 outer wall of liquid storage pipe, then the enzyme-to-substrate mixed can flow through 8 cavity of sampling wiper sub bar
And it is reacted from the outflow of sampling wiper sub bar hole 9 with the sample contents on cotton head B.
The embodiment of the present invention 2: severe feeding microculture
As shown in figure 1i, 2 device of the present embodiment can be applied to severe feeding microculture.It is supported in clinical detection sample containing severe
Microorganism, such as Neisseria.This quasi-microorganism is more stringent to the environmental requirement for transporting culture, it is desirable that contains in culture environment
The carbon dioxide of 5%-10%.Meanwhile pattern detection terminates, and to avoid sample contamination environment, can add fungicide in the device.
As shown in figure 1i, fungicide is placed in ampoul tube 2, is placed citric acid solution in liquid storage pipe 1, is separated with liquid separatnig valve 4, liquid separatnig valve 4
Powdered sodium carbonate is placed in gap A between sampling wiper sub bar fixinig plate 7, separates that (porous membrane 6 is located at porous membrane 6
In the A of gap, it is close to sampling wiper sub bar fixinig plate 7, sees Fig. 1 i).It is sampled in use, taking out sampling wiper sub bar 8, in retrieval device.
Fracture the needle 5 of liquid separatnig valve 4, squeeze in 1 outer wall of liquid storage pipe release citric acid to gap A with sodium carbonate hybrid reaction therein,
The carbon dioxide of generation is repeatedly squeezed 1 outer wall of liquid storage pipe and is mixed by the cavity of sampling wiper sub bar 8 with sample.Make sample
It is stored in the environment of enough humidity and carbon dioxide, improves the activity of severe feeding microorganism.After reaching test point, taking-up contains sample
This sampling wiper sub bar 8 is coated with culture.Coating terminates, and in 8 retrieval device of sampling wiper sub bar, will rack the release sterilization of ampoul tube 2
Agent, fungicide and swab cotton head B are acted on, and the thallus carried on sample are killed, whole device does not have to sterilization treatment can be reasonable
Disposition.
The embodiment of the present invention 3: sample pre-treatments
As shown in Figure 2 a, 3 device of the present embodiment can be applied to the pre-treatment of similar whole blood sample.As shown in Figure 2 a, liquid
State colloidal gold can be placed in the storage chamber that liquid separatnig valve 4 and liquid storage pipe 1 are formed, between liquid separatnig valve 4 and sampling wiper sub bar fixinig plate 7
Gap A in place cell cracking agent (such as TritonX-100), separate that (porous membrane 6 is located at gap A with porous membrane 6
It is interior, be close to sampling wiper sub bar fixinig plate 7, see Fig. 2 a).In use, rotating out of the junction of liquid storage pipe 1 Yu reaction tube 10, take out
Sampling wiper sub bar 8 samples.Sample acquisition terminates, and sampling wiper sub bar 8 is turned back in reaction tube 10 and entangled firm with liquid storage pipe 1 screws.
Secondly, the needle 5 of disconnected liquid separatnig valve 4 is broken, between release liquid colloidal gold flows through between liquid separatnig valve 4 and sampling wiper sub bar fixinig plate 7
Gap A is reacted with cell cracking agent, repeatedly squeezes 1 outer wall of liquid storage pipe, passes liquid through the cavity of sampling wiper sub bar 8 from sampling wiper
The outflow of sub bar hole 9 is mixed with the sample contents on cotton head B, to handle sample.Sample treatment terminates, and breaks the tail of disconnected reaction tube 10
The snap bar 12 of the adapter 11 at end takes out the outer tube 13 of reaction tube 10, and the outer wall of extruding reaction pipe 10, liquid is from linking
11 port of device oozes, and detects on Test paper card.
The embodiment of the present invention 4: Antigen extraction reagent is prepared
As shown in Figure 2 b, 4 device of the present embodiment can be applied to the two-component reagent that similar acetic acid and sodium nitrite react.
Reaction generates nitrous acid after the mixing of both components.Nitrous acid is that the common extraction A race in microbe diagnosis field is streptococcic anti-
Original reagent, but nitrous acid and unstable need to prepare and utilize in time.Simultaneously as nitrous acid is acidic materials, upper test strips
It needs to adjust pH condition between detection.Therefore, as shown in Figure 2 b, acetic acid can be placed in the storage chamber that liquid separatnig valve 4 and liquid storage pipe 1 are formed
In, acid-base neutralization reagent is placed in ampoul tube 2, and stoppers ampoul tube lid 3.Between liquid separatnig valve 4 and sampling wiper sub bar fixinig plate 7
Gap A in place sodium nitrite, separate that (porous membrane 6 is located in the A of gap, and abutting sampling wiper sub bar is fixed with porous membrane 6
Piece 7, is shown in Fig. 2 b).In use, rotating out of the junction of liquid storage pipe 1 Yu reaction tube 10, takes out sampling wiper sub bar 8 and sample.Sample is adopted
Collection terminates, and sampling wiper sub bar 8 is turned back in reaction tube 10 and entangled firm with liquid storage pipe 1 screws.Secondly, breaking the needle of disconnected liquid separatnig valve 4
5, the gap A that release liquid flows through between liquid separatnig valve 4 and sampling wiper sub bar fixinig plate 7 is reacted with sodium nitrite, repeatedly squeezes storage
1 outer wall of liquid pipe, the cavity for passing liquid through sampling wiper sub bar 8 are mixed from the outflow of sampling wiper sub bar hole 9 and the sample contents on cotton head B
It closes, to extract sample antigen.Finally, discharging acid-base neutralization reagent by broken ampoul tube 2, acid-base neutralization reagent reaches cotton head B's
Position and neutralization reaction product.Extraction terminates, and breaks the snap bar 12 of the adapter 11 of the tail end of disconnected reaction tube 10, takes out reaction tube
10 outer tube 13, the outer wall of extruding reaction pipe 10, liquid are flowed out from 11 port of adapter.It can be in A race streptococcus Test paper
Detection or external small tubes collect antigen on card.
Claims (11)
1. a kind of device for integrating sampling, reaction, detection, which is characterized in that the device includes: liquid storage pipe (1), liquid separatnig valve
(4), fixinig plate (7), sampling wiper sub bar (8), reaction tube (10)；Liquid separatnig valve (4) is equipped with broken needle (5)；Fixinig plate
(7) sampling wiper sub bar (8) are connected；Liquid separatnig valve (4) is packed into liquid storage pipe (1) inner cavity, and what liquid storage pipe (1) and liquid separatnig valve (4) were formed deposits
Storage chamber is provided with solution, and the needle (5) of liquid separatnig valve (4) is located in the storage chamber；Fixinig plate (7) is packed into liquid storage pipe (1), with
It is equipped with gap (A) between liquid separatnig valve (4), chemical substance is placed in gap (A)；The open end of liquid storage pipe (1) puts on reaction tube
(10)；The liquid storage pipe (1) is made of clear supple material.
2. the apparatus according to claim 1, which is characterized in that be additionally provided with porous membrane (6) in the gap (A).
3. the apparatus according to claim 1, it is characterised in that: one end of the sampling wiper sub bar (8) be equipped with aseptic cotton carrier,
Oese or spiral sampling cone, the other end are inserted into the cavity of fixinig plate (7).
4. the apparatus according to claim 1, it is characterised in that: the reaction tube (10) is flexible transparent flexible pipe
Body.
5. the apparatus according to claim 1, it is characterised in that: the tail end of the reaction tube (10) is equipped with band snap bar (12)
Adapter (11), and set outer tube (13) and cover in the outside of adapter (11)；Adapter (11) cavity is hollow, snap bar
It (12) is solid.
6. a kind of device for integrating sampling, reaction, detection, which is characterized in that the device includes: liquid storage pipe (1), can be damaged
Ampoul tube (2), liquid separatnig valve (4), fixinig plate (7), sampling wiper sub bar (8), reaction tube (10)；Liquid separatnig valve (4) is equipped with broken
Needle (5)；Fixinig plate (7) connects sampling wiper sub bar (8)；Liquid separatnig valve (4) be packed into liquid storage pipe (1) inner cavity, liquid storage pipe (1) and divide
The storage chamber that liquid valve (4) is formed is provided with solution, and the needle (5) of liquid separatnig valve (4) is located at outside the storage chamber；It is described damaged to pacify
Small jar pipe (2) is preinstalled with chemical substance, and is packed into the storage chamber；Fixinig plate (7) is packed into liquid storage pipe (1), with liquid separatnig valve (4)
Between be equipped with gap (A), chemical substance is placed in gap (A)；The open end of liquid storage pipe (1) puts on reaction tube (10)；The storage
Liquid pipe (1) is made of clear supple material.
7. device according to claim 6, it is characterised in that: be additionally provided with porous membrane (6) in the gap (A).
8. device according to claim 6, it is characterised in that: one end of the sampling wiper sub bar (8) be equipped with aseptic cotton carrier,
Oese or spiral sampling cone, the other end are inserted into the cavity of fixinig plate (7).
9. device according to claim 6, it is characterised in that: the reaction tube (10) is flexible transparent flexible pipe
Body.
10. device according to claim 6, it is characterised in that: the tail end of the reaction tube (10) is equipped with band snap bar
(12) adapter (11), and set outer tube (13) and cover in adapter (11) outside；Adapter (11) cavity is hollow, fractures
Bar (12) is solid.
11. device according to claim 6, it is characterised in that: it is described can damaged ampoul tube (2) be multiple.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201610480687.2A CN106053121B (en) | 2016-06-27 | 2016-06-27 | Integrate the device of sampling, reaction, detection |
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| CN201610480687.2A CN106053121B (en) | 2016-06-27 | 2016-06-27 | Integrate the device of sampling, reaction, detection |
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| CN106053121B true CN106053121B (en) | 2019-05-03 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107837097A (en) * | 2017-10-24 | 2018-03-27 | 刘永红 | A kind of cotton swab device for being applied to sampling |
| CN112387224B (en) * | 2020-10-30 | 2022-05-13 | 珠海市人民医院 | Anti-sputtering reaction bottle |
| WO2022231537A1 (en) * | 2021-04-30 | 2022-11-03 | Ivd Bi̇yoteknoloji̇ Sanayi̇ Ti̇caret Anoni̇m Şi̇rketi̇ | A tube structure used in molecular diagnostic systems |
| CN116400076B (en) * | 2023-03-07 | 2024-02-23 | 湖北工业大学 | Sampling, reaction and detection integrated device |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4978504A (en) * | 1988-02-09 | 1990-12-18 | Nason Frederic L | Specimen test unit |
| CN100386613C (en) * | 2005-02-03 | 2008-05-07 | 益思美诠生物科技(上海)有限公司 | Sample collecting and testing device |
| TW200712487A (en) * | 2005-08-02 | 2007-04-01 | 3M Innovative Properties Co | Apparatus and method for detecting an analyte |
| CN1806792A (en) * | 2006-01-05 | 2006-07-26 | 长沙楚天科技有限公司 | Dual chambered transfusion bag with built-in pervious barrier |
| CN201476980U (en) * | 2009-08-20 | 2010-05-19 | 苏州浦隆生物有限公司 | Device for sampling and testing |
| CN203490093U (en) * | 2013-08-12 | 2014-03-19 | 深圳华大基因研究院 | Sample collecting device |
| CN203672692U (en) * | 2013-12-27 | 2014-06-25 | 益思美诠生物科技(上海)有限公司 | Sample processing system |
| CN105527257B (en) * | 2014-10-22 | 2019-04-23 | 肖特玻璃科技(苏州)有限公司 | Measure the method and apparatus and application thereof of antibacterial glass |
| CN205826329U (en) * | 2016-06-27 | 2016-12-21 | 益思美诠生物科技(上海)有限公司 | Collection is sampled, reacts, is detected as device integrally |
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