CN106038754A - Medicine composition for preventing and treating cervical cancer and preparation method thereof - Google Patents
Medicine composition for preventing and treating cervical cancer and preparation method thereof Download PDFInfo
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- 206010008342 Cervix carcinoma Diseases 0.000 title claims abstract description 47
- 201000010881 cervical cancer Diseases 0.000 title claims abstract description 45
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 title claims abstract description 44
- 238000002360 preparation method Methods 0.000 title claims abstract description 29
- 239000000203 mixture Substances 0.000 title claims abstract description 25
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- 244000166124 Eucalyptus globulus Species 0.000 claims abstract description 24
- 235000013399 edible fruits Nutrition 0.000 claims abstract description 23
- 241001299296 Lysimachia hemsleyana Species 0.000 claims abstract description 22
- 241001495640 Galium boreale Species 0.000 claims abstract description 21
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 140
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/57—Birds; Materials from birds, e.g. eggs, feathers, egg white, egg yolk or endothelium corneum gigeriae galli
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/51—Gentianaceae (Gentian family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/55—Liquid-liquid separation; Phase separation
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- Health & Medical Sciences (AREA)
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- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
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- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
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Abstract
The invention discloses a medicine composition for preventing and treating cervical cancer and a preparation method thereof. The medicine composition is prepared from the following medicinal raw materials: galium boreale, fruits of eucalyptus globules, lysimachia hemsleyana, crake and centaurium pulchellum according to a proportion. Various preparations can be prepared from the medicine composition according to a conventional preparation process. The medicine composition has a remarkable treatment effect on prevention and treatment of cervical cancer.
Description
Technical field
The invention belongs to technical field of Chinese medicines, particularly relate to a kind of pharmaceutical composition preventing and treating cervical cancer and preparation side thereof
Method.
Background technology
Cervical cancer is the malignant tumor that female sex organ is common, the life of serious harm patient.For a part of cervix uteri
Cancer postoperative patient or find evening, lose surgical engine meeting person, radiotherapy is an important channel in combined therapy of tumour and hands
Section.Radiotherapy, while killing massive tumor cell, also produces infringement in various degree, shows as some merit body
, there is one or more untoward reaction or complication, even results in death in energy obstacle.The chief complaint of chronic radiation disease is relatively
Many, with weak, headache, dizzy, hypomnesis, sleep disorder, emotional, alopecia, loss of appetite, cardiopalmus,
Breathe hard, hyperhidrosis, the enuresis etc..The most again with fatigue and weak, sleep disorder, loss of appetite, dizzy, headache, memory subtracts
The symptom such as move back to occur the earliest.Radiotherapy damage gastrointestinal function person, may occur in which stomachache, have blood in stool, tenesmus, dietary amount lack etc.
Disease.Hemopoietic function of bone marrow is caused damage, occurs bone marrow depression to occur that peripheral blood leucocyte declines, make the radiotherapy can not
Adhere to.And radioactive all untoward reaction, Western medicine is often without special efficacy, and therefore, application Chinese medicine is patient
Reduce misery to be of great practical significance.There is no effective medicine at present.
Carnis Rallus aquaticus: this product is the meat that Rallidae Carnis Rallus aquaticus belongs to animal Carnis Rallus aquaticus Rallus apuaticus (Linnaeus).The four seasons are equal
Can catch, after catching, remove feather and internal organs, take meat.[nature and flavor] sweet in the mouth；Warm in nature.[return through] large intestine channel.[function cures mainly] detoxifies
Parasite killing；Invigorating the spleen and replenishing QI.Main ant fistula；Weakness of the spleen and stomach；Inappetence.[former zoomorphism] Carnis Rallus aquaticus, body is about 30cm.Little；Neck
Long.Upper body feather taupe, band black speckle, head speckle is the most significant.Two wing surfaces are the most grey brown.Lower body brown, two
Axil tool white macula；Crissum is identical with lower tall coverts black and white, plumage end white.Shin plumage is black and has white horizontal speckle.Mouth is dark brown, and lower mouth base portion is relatively
Light.Foot sepia.Record in Chinese medicine voluminous dictionary.
Northern bedstraw: for the herb of Rubiaceae clivers Herba Galii borealis Galium boreale L..Autumn gathers,
Cutting is dried.[nature and flavor] are bitter；Cold.[function cures mainly] heat-clearing and toxic substances removing；Expelling wind and activating blood circulation.Main pneumonia is coughed；Oedema due to nephritis；Lumbago and skelalgia
Bitterly；Women's amenorrhea；Dysmenorrhea；Leukorrhagia；Skin ulcer tinea.[chemical analysis] is containing quintessence oil, Coumarins, flavonoid and anthraquinone analog compound.
[former phytomorph] Herba Galii borealis, perennial vertical herbage, high 20-50cm.Stem has four ribs, has branch, near without hair or joint portion
There is microtriche.4, leaf is verticillate；Stockless；Blade wire lanceolar, long 1-3.5cm, wide 2-4mm, tip is blunt, the wealthy wedge shape of base portion or near
Circle, edge slightly warp.Base goes out 3, arteries and veins, and flash trimming edge has outside microtriche, and two without hair.Cyme top is raw, or forms band at Zhi Ding
The panicle shape of leaf；Hua Mi, little, yellow-white；The long 3-5mm of pedicel；Sepal 4, ellipticity is avette, has thin hair, and tip is short gradually
Point；Stamen 4, with sepal alternate；Ovary is the next, and subsphaeroidal, style 2 splits to nearly base portion.Fruit is spherical, little, black, close white
Glochild.The month at florescence 6-8, really the phase 7-9 month.Record in Chinese medicine voluminous dictionary.
Eucalyptus fruit: this product is the fruit of myrtle Eucalyptus globulus Labill Eucalyptus globulus Labill..Summer or
Gather during fruit maturation in winter, dry.[nature and flavor] acrid in the mouth；Bitter；Slightly warm in nature；Mild toxicity.[function cures mainly] regulates the flow of vital energy；Stomach invigorating；Plant malaria；
Antipruritic.Staple food amasss；Abdominal distention；Malaria；Dermatitis；Tinea skin ulcer.[former phytomorph] Eucalyptus globulus Labill, evergreen megaphanerophyte.Bark dusty blue, toward shape
Peel off；Twig slightly rib.Young tender leaf is to life；Blade is avette, and base portion is heart-shaped, and stockless has white lead；Growth blade keratin, lanceolar,
Falciform, long 15-30cm, wide 1-2cm, there is a gland point on two sides, and the long 1.5-3cm of petiole is the most flat.Hua great, white, footpath about 4cm, Dan Sheng
Or 2-3 consor is in axil；Without bennet or extremely short；Calyx pipe turbination, long 1cm, wide 1.3cm, there are 4 projection corner angle on surface
Projection is closed, by white lead with tubercle；Calyptra is the most flat, and middle part is conical papilla, shorter than calyx pipe, 2 layers, and outer layer smooths, caducous；
Stamen is most, long 8-13mm, multiple row, and filigree is very thin, and is born in the middle part of flower pesticide, and flower pesticide is oval, wealthy ear lobe；Ovary and calyx
Pipe symphysis, the long 7-8mm of style is thick.Capsule hemispherical, has 4 ribs, wide 2-2.5cm, and really edge is flat and wide, and really lobe does not highlights.The really phase
Summer and winter.Record in Chinese medicine voluminous dictionary.
Herba centaurll altaici: this product is Gentianaceae centaurium Centaurium meyeri Druce Centaurium pulchellum Druce
Var.al-taicum (Griseb.) Kitag.et Hara [Erythraea ramosissima var.al-taica
Griseb.;Centaurium meyeri(Bunge) Druce wounded in the battle herb.Gather when blooming, dry.[nature and flavor] are bitter；Property
Cold.[return through] liver；Stomach warp.[function cures mainly] heat-clearing and toxic substances removing.Main hepatitis；Cholecystitis；Have a headache and fever；Toothache；Tonsillitis.[former
Phytomorph] annual herb, high 20～30 centimetres.Stem four prismatic, has branch.Leaf is to life, stockless, lanceolar, length 1.5～2
Centimetre, wide 4～6 millimeters.Flower axil is raw or top is raw, spends more, and calyx 5 splits；Corolla white or lavender, 5 split, and cylindrical fireworks are elongated；Stamen 5,
Flower pesticide Long Circle, Post flowering crimps in the shape of a spiral.The long cylindricality of capsule, florescence 7～JIUYUE.Record in Chinese medicine voluminous dictionary.
Lysimachia hemsleyana: this product is Primulaceae Lysimachia plant Lysimachia hemsleyana Lysimachia hemsleyana
Maxim. herb.Summer gathers, and dries.[nature and flavor] micro-hardship；Cool in nature.[function cures mainly] clearing away heat-damp and promoting diuresis；Stimulate the menstrual flow.Main hepatitis；
Pyelonephritis；Cystitis；Amenorrhea.[chemical analysis] herb is isolated potassium chloride and mixing saccharide, preliminary examination still have flavonoid,
Saponin, glycoside, lactone and organic acid etc. react.[pharmacological action] choleretic effect rat is administered orally 100% Lysimachia hemsleyana and decocts every day
Agent 5m1, in continuous 6 weeks, in the case of general anesthesia acute experiment, compares with matched group, has the effect promoting bile excretion.As
Dosage is relatively low or ophthalmically acceptable phase is short, then act on inconspicuous, and continuous eye decoct is after 2-3 days, and animal feces is thinning, and color becomes sepia,
But do not find intoxicating phenomenon.Rat is without gallbladder, therefore promotes that the excretion of bile is not by strengthening caused by gallbladder contraction.Record in
Medicine voluminous dictionary.
Summary of the invention
It is an object of the invention to overcome the deficiency of background technology, it is provided that a kind of pharmaceutical composition effectively preventing and treating cervical cancer and
Its preparation method.
The present invention adopts the following technical scheme that realization:
Composition and the weight portion of making the crude drug of this pharmaceutical composition preventing and treating cervical cancer be:
Northern bedstraw 306-310 weight portion Eucalyptus fruit 282-288 weight portion Lysimachia hemsleyana 10-14 weight portion Carnis Rallus aquaticus 162-164 weight
Amount part Herba centaurll altaici 60-62 weight portion.
It is preferably used in the pharmaceutical composition preventing and treating cervical cancer, is made up of the crude drug of following weight portion:
Northern bedstraw 308 weight portion Eucalyptus fruit 285 weight portion Lysimachia hemsleyana 12 weight portion Carnis Rallus aquaticus 163 weight portion Herba centaurll altaici 61 weight
Part.
A kind of pharmaceutical composition preventing and treating cervical cancer, it is characterised in that pharmaceutical composition can use the routine side of galenic pharmacy
Method prepares piece agent or capsule or drop pill.
A kind of pharmaceutical composition preventing and treating cervical cancer, it is characterised in that pharmaceutical composition is anti-with what chemical drugs or Chinese medicine formed
Control cervical cancer medicine.
The preparation method of a kind of pharmaceutical composition preventing and treating cervical cancer, it is characterised in that prepare as follows:
The composition of crude drug and weight portion be: northern bedstraw 306-310 weight portion Eucalyptus fruit 282-288 weight portion Lysimachia hemsleyana
10-14 weight portion Carnis Rallus aquaticus 162-164 weight portion Herba centaurll altaici 60-62 weight portion；
Preparation method:
(1) northern bedstraw, Eucalyptus fruit, Lysimachia hemsleyana, Carnis Rallus aquaticus, Herba centaurll altaici are taken by crude drug proportioning, mixing, use weight percent concentration
44% ethanol, as solvent, extracts at 26 DEG C of warm macerating, and extraction time is 28 times, and each extraction time is 28 hours, and each solvent is used
Amount is 53 times of crude drug gross weight, filters, obtains medicinal residues A and extracting solution A, extracting solution A and reclaim ethanol, be concentrated into relative density
1.07, filter, medicinal liquid passes through FU-01 macroporous adsorptive resins, first washes with water, more molten with weight percent concentration 35% ethanol
Liquid eluting FU-01 macroporous adsorptive resins, collection weight percent concentration 35% ethanol elution, recovery ethanol, concentrate drying,
Obtain extract A；
(2) take step (1) medicinal residues A, with weight percent concentration 82% ethanol as solvent, heating and refluxing extraction 15 times, carry every time
The time of taking is 0.1 hour, and each solvent load is 62 times of medicinal residues A weight, filters, obtains medicinal residues B and extracting solution B, and extracting solution B returns
Receiving ethanol, be concentrated into relative density 1.14, filter, medicinal liquid passes through SIP1200 macroporous adsorptive resins, first washes with water, then uses
Weight percent concentration 40.6% ethanol solution eluting SIP1200 macroporous adsorptive resins, collects weight percent concentration 40.6%
Ethanol elution, reclaims ethanol, concentrate drying, obtains extract B；
(3) extract A and extract B are mixed, obtain pharmaceutical composition.
The preparation method of a kind of pharmaceutical composition preventing and treating cervical cancer, it is characterised in that prepare as follows:
The composition of crude drug and weight portion be: northern bedstraw 308 weight portion Eucalyptus fruit 285 weight portion Lysimachia hemsleyana 12 weight portions
Carnis Rallus aquaticus 163 weight portion Herba centaurll altaici 61 weight portion；
Preparation method:
(1) northern bedstraw, Eucalyptus fruit, Lysimachia hemsleyana, Carnis Rallus aquaticus, Herba centaurll altaici are taken by crude drug proportioning, mixing, use weight percent concentration
44% ethanol, as solvent, extracts at 26 DEG C of warm macerating, and extraction time is 28 times, and each extraction time is 28 hours, and each solvent is used
Amount is 53 times of crude drug gross weight, filters, obtains medicinal residues A and extracting solution A, extracting solution A and reclaim ethanol, be concentrated into relative density
1.07, filter, medicinal liquid passes through FU-01 macroporous adsorptive resins, first washes with water, more molten with weight percent concentration 35% ethanol
Liquid eluting FU-01 macroporous adsorptive resins, collection weight percent concentration 35% ethanol elution, recovery ethanol, concentrate drying,
Obtain extract A；
(2) take step (1) medicinal residues A, with weight percent concentration 82% ethanol as solvent, heating and refluxing extraction 15 times, carry every time
The time of taking is 0.1 hour, and each solvent load is 62 times of medicinal residues A weight, filters, obtains medicinal residues B and extracting solution B, and extracting solution B returns
Receiving ethanol, be concentrated into relative density 1.14, filter, medicinal liquid passes through SIP1200 macroporous adsorptive resins, first washes with water, then uses
Weight percent concentration 40.6% ethanol solution eluting SIP1200 macroporous adsorptive resins, collects weight percent concentration 40.6%
Ethanol elution, reclaims ethanol, concentrate drying, obtains extract B；
(3) extract A and extract B are mixed, obtain pharmaceutical composition.
The preparation method of a kind of pharmaceutical composition preventing and treating cervical cancer, it is characterised in that pharmaceutical composition can use preparation
The conventional method learned is prepared as tablet or capsule or drop pill.
A kind of preparation method of the pharmaceutical composition preventing and treating cervical cancer, it is characterised in that pharmaceutical composition and chemical drugs or in
Medicine composition prevents and treats cervical cancer medicine.
It is evident in efficacy that pharmaceutical composition prevents and treats cervical cancer.
Detailed description of the invention
Embodiment 1: pharmaceutical composition preventing and treating cervical cancer and preparation method thereof
Composition and the weight portion of preventing and treating the crude drug of the pharmaceutical composition of cervical cancer be: northern bedstraw 308g Eucalyptus fruit 285g point gland mistake
Road Huang 12g Carnis Rallus aquaticus 163g Herba centaurll altaici 61g；
Preparation method:
(1) northern bedstraw, Eucalyptus fruit, Lysimachia hemsleyana, Carnis Rallus aquaticus, Herba centaurll altaici are taken by crude drug proportioning, mixing, use weight percent concentration
44% ethanol, as solvent, extracts at 26 DEG C of warm macerating, and extraction time is 28 times, and each extraction time is 28 hours, and each solvent is used
Amount is 53 times of crude drug gross weight, filters, obtains medicinal residues A and extracting solution A, extracting solution A and reclaim ethanol, be concentrated into relative density
1.07, filter, medicinal liquid passes through FU-01 macroporous adsorptive resins, first washes with water, more molten with weight percent concentration 35% ethanol
Liquid eluting FU-01 macroporous adsorptive resins, collection weight percent concentration 35% ethanol elution, recovery ethanol, concentrate drying,
Obtain extract A；
(2) take step (1) medicinal residues A, with weight percent concentration 82% ethanol as solvent, heating and refluxing extraction 15 times, carry every time
The time of taking is 0.1 hour, and each solvent load is 62 times of medicinal residues A weight, filters, obtains medicinal residues B and extracting solution B, and extracting solution B returns
Receiving ethanol, be concentrated into relative density 1.14, filter, medicinal liquid passes through SIP1200 macroporous adsorptive resins, first washes with water, then uses
Weight percent concentration 40.6% ethanol solution eluting SIP1200 macroporous adsorptive resins, collects weight percent concentration 40.6%
Ethanol elution, reclaims ethanol, concentrate drying, obtains extract B；
(3) extract A and extract B are mixed, obtain pharmaceutical composition.
Embodiment 2: pharmaceutical composition preventing and treating cervical cancer and preparation method thereof
Composition and the weight portion of preventing and treating the crude drug of the pharmaceutical composition of cervical cancer be: northern bedstraw 306g Eucalyptus fruit 288g point gland mistake
Road Huang 10g Carnis Rallus aquaticus 164g Herba centaurll altaici 60g；
Preparation method:
(1) northern bedstraw, Eucalyptus fruit, Lysimachia hemsleyana, Carnis Rallus aquaticus, Herba centaurll altaici are taken by crude drug proportioning, mixing, use weight percent concentration
44% ethanol, as solvent, extracts at 26 DEG C of warm macerating, and extraction time is 28 times, and each extraction time is 28 hours, and each solvent is used
Amount is 53 times of crude drug gross weight, filters, obtains medicinal residues A and extracting solution A, extracting solution A and reclaim ethanol, be concentrated into relative density
1.07, filter, medicinal liquid passes through FU-01 macroporous adsorptive resins, first washes with water, more molten with weight percent concentration 35% ethanol
Liquid eluting FU-01 macroporous adsorptive resins, collection weight percent concentration 35% ethanol elution, recovery ethanol, concentrate drying,
Obtain extract A；
(2) take step (1) medicinal residues A, with weight percent concentration 82% ethanol as solvent, heating and refluxing extraction 15 times, carry every time
The time of taking is 0.1 hour, and each solvent load is 62 times of medicinal residues A weight, filters, obtains medicinal residues B and extracting solution B, and extracting solution B returns
Receiving ethanol, be concentrated into relative density 1.14, filter, medicinal liquid passes through SIP1200 macroporous adsorptive resins, first washes with water, then uses
Weight percent concentration 40.6% ethanol solution eluting SIP1200 macroporous adsorptive resins, collects weight percent concentration 40.6%
Ethanol elution, reclaims ethanol, concentrate drying, obtains extract B；
(3) extract A and extract B are mixed, obtain pharmaceutical composition.
Embodiment 3: pharmaceutical composition preventing and treating cervical cancer and preparation method thereof
Composition and the weight portion of preventing and treating the crude drug of the pharmaceutical composition of cervical cancer be: northern bedstraw 310g Eucalyptus fruit 282g point gland mistake
Road Huang 14g Carnis Rallus aquaticus 162g Herba centaurll altaici 62g；
Preparation method:
(1) northern bedstraw, Eucalyptus fruit, Lysimachia hemsleyana, Carnis Rallus aquaticus, Herba centaurll altaici are taken by crude drug proportioning, mixing, use weight percent concentration
44% ethanol, as solvent, extracts at 26 DEG C of warm macerating, and extraction time is 28 times, and each extraction time is 28 hours, and each solvent is used
Amount is 53 times of crude drug gross weight, filters, obtains medicinal residues A and extracting solution A, extracting solution A and reclaim ethanol, be concentrated into relative density
1.07, filter, medicinal liquid passes through FU-01 macroporous adsorptive resins, first washes with water, more molten with weight percent concentration 35% ethanol
Liquid eluting FU-01 macroporous adsorptive resins, collection weight percent concentration 35% ethanol elution, recovery ethanol, concentrate drying,
Obtain extract A；
(2) take step (1) medicinal residues A, with weight percent concentration 82% ethanol as solvent, heating and refluxing extraction 15 times, carry every time
The time of taking is 0.1 hour, and each solvent load is 62 times of medicinal residues A weight, filters, obtains medicinal residues B and extracting solution B, and extracting solution B returns
Receiving ethanol, be concentrated into relative density 1.14, filter, medicinal liquid passes through SIP1200 macroporous adsorptive resins, first washes with water, then uses
Weight percent concentration 40.6% ethanol solution eluting SIP1200 macroporous adsorptive resins, collects weight percent concentration 40.6%
Ethanol elution, reclaims ethanol, concentrate drying, obtains extract B；
(3) extract A and extract B are mixed, obtain pharmaceutical composition.
Embodiment 4: the preparation of tablet
Example 1 pharmaceutical composition 79g, adds starch 62g, mixing, pelletizes, be dried, add microcrystalline Cellulose 44g, stearic acid
Magnesium 5g, mixing, it is pressed into 200, obtains medicinal composition tablets.
Embodiment 5: the preparation of capsule
Example 2 pharmaceutical composition 65g, adds starch 59g, mixing, pelletizes, be dried, granulate, add appropriate magnesium stearate,
Mixing, obtains medicament composition capsule by encapsulated 250.
Embodiment 6: the preparation of drop pill
Weigh polyethylene glycol 6000 171g water-bath (80 DEG C) heating and boil molten, add embodiment 3 pharmaceutical composition 11.2g, fully
Stirring, with liquid paraffin as coolant, put in glass tubing (4*80cm), chilling temperature is 6 DEG C, and drip internal-and external diameter is 7.0/
2.0 (mm/mm), drip is 2.2cm away from liquid level, drips fast with 51 every point as optimum condition, blots the cold of drop pill surface with cotton
Solidifying agent, obtains medicament composition dropping pills.
Embodiment 7: prevent and treat the pharmaceutical composition of cervical cancer
Composition and the weight portion of preventing and treating the crude drug of the pharmaceutical composition of cervical cancer be:
Lysimachia hemsleyana 8 weight portion Carnis Rallus aquaticus 180 weight portion Eucalyptus fruit 290 weight portions.
Embodiment 8: prevent and treat the pharmaceutical composition of cervical cancer
Composition and the weight portion of preventing and treating the crude drug of the pharmaceutical composition of cervical cancer be:
Lysimachia hemsleyana 12 weight portion Carnis Rallus aquaticus 150 weight portion Herba centaurll altaici 60 weight portion.
Embodiment 9: prevent and treat the pharmaceutical composition of cervical cancer
Composition and the weight portion of preventing and treating the crude drug of the pharmaceutical composition of cervical cancer be:
Lysimachia hemsleyana 3.5 weight portion Carnis Rallus aquaticus 140 weight portion Herba centaurll altaici 70 weight portion.
Experimental example 1: prevent and treat the experimental study of cervical cancer
1.1 material
1.1.1 medicine
Embodiment 1 pharmaceutical composition, lot number 20110821, concentration 0.7g ml (containing raw medicinal herbs).
1.1.2 object is detected
Selected from the cervical cancer patient of this city tumour hospital, make a definite diagnosis by stages by international alliance of woman Congress of Industrial Organizations (FIGO), case history be IIb with
On, totally 32 example, all confirm through histopathology, wherein squamous carcinoma of the cervix 16 example, adenocarcinoma of the uterine cervix 10 example, cervical gland scale cancer 6 example.
1.2 method
1.2.1 packet is tested
32 example cervical cancer patients are randomly divided into two groups, pharmaceutical composition combination with radiotherapeutic (observation group) 16 example, radiation alone (radiotherapy
Group) 16 examples, the age 29～62 years old, average 41.6 years old.32 example patients are the most unused in first 3 months of observation crosses Radiotherapy chemotherapy person, sees
Amcinonide, medicine influential on hemogram and immunotherapy is disabled during examining.
1.2.2 Therapeutic Method
Combination radiotherapy group, according to patient's concrete condition, arranges radiotherapy amount；Observation group adds while the radiotherapy in the treatment as combination radiotherapy group
Take medicine compositions, oral, a 1.5g, three times a day.Being admitted to hospital to rise next day and start treatment, 20d is 1 course for the treatment of.
1.2.3 detection method empirically room standard method counting peripheral blood leucocyte, platelet change.
1.2.4 statistical method uses χ2Inspection and t inspection.
2 results
2.1 pharmaceutical compositions are on impact about clinical symptoms after radiotherapy patients with cervix carcinoma
The results are shown in Table 1.
About the comparison (n) of clinical symptoms after 1 liang of table group Patients Treated by Radiotherapy
| Packet | n | Loss of appetite | Nausea and vomiting | Abdominal distention is suffered from diarrhoea | Dizzy | Insomnia | Weak |
| Combination radiotherapy group | 16 | 10 | 9 | 7 | 6 | 4 | 8 |
| Observation group | 16 | 4** | 5* | 3** | 0** | 1* | 2** |
Note: compare with combination radiotherapy group, * P < 0.05, * * P < 0.01.
As it can be seen from table 1 observation group's loss of appetite, abdominal distention diarrhoea, dizzy, weak, and the disease such as nausea and vomiting, insomnia
Shape improves, and compares with combination radiotherapy group and all has significant difference (P < 0.05 or P < 0.01), shows that pharmaceutical composition can substantially be alleviated
Side reaction symptom in Patients During Radiotherapy.
2.2 pharmaceutical compositions are on peripheral blood leucocyte after radiotherapy patients with cervix carcinoma and hematoblastic impact
The results are shown in Table 2.
Peripheral blood leucocyte and hematoblastic comparison after 2 liang of table group Patients Treated by Radiotherapy (x ± s, × 109/L)
Note: two groups self are compared,△△P<0.01；Compare after treating with combination radiotherapy group, * P < 0.05.
From table 2 it can be seen that leukocyte and platelet are decreased obviously after combination radiotherapy group treatment, there is significance compared with before treatment
Difference (P < 0.01), after observation group's treatment, leukocyte and platelet also have decline in various degree, but nothing compared with before treatment
Significant difference (P > 0.05), compares leukocyte platelet without significant difference before two groups of treatments, compares leukocyte after two groups of treatments
And platelet has significant difference (P < 0.05).
Result shows, the number that observation group chemotherapy side effect symptom occurs is considerably less than combination radiotherapy group, and two groups are compared and have
Significance and pole significant difference.After combination radiotherapy group treatment, leukocyte and platelet are decreased obviously (P < 0.01), and observation group treats
Rear leukocyte and platelet have declined, but there was no significant difference (P > 0.05) compared with before treatment.Patients During Radiotherapy is described
In, drug application compositions can alleviate the side reaction alleviating radiotherapy.Observation group's hemogram declines very slow, and amplitude is little, bone marrow depression
Relatively light, thus demonstrate pharmaceutical composition and can improve the cervical cancer patient tolerance to radiotherapy, beneficially patient after radiotherapy
Recover, and then improve the life quality of patient.
Claims (8)
1. the pharmaceutical composition preventing and treating cervical cancer, it is characterised in that make composition and the weight of the crude drug of this pharmaceutical composition
Amount part is:
Northern bedstraw 306-310 weight portion Eucalyptus fruit 282-288 weight portion Lysimachia hemsleyana 10-14 weight portion Carnis Rallus aquaticus 162-164 weight
Amount part Herba centaurll altaici 60-62 weight portion.
A kind of pharmaceutical composition preventing and treating cervical cancer, it is characterised in that make this pharmaceutical composition
The composition of crude drug and weight portion be:
Northern bedstraw 308 weight portion Eucalyptus fruit 285 weight portion Lysimachia hemsleyana 12 weight portion Carnis Rallus aquaticus 163 weight portion Herba centaurll altaici 61 weight
Part.
A kind of pharmaceutical composition preventing and treating cervical cancer, it is characterised in that pharmaceutical composition can be adopted
It is prepared as tablet or capsule or drop pill by the conventional method of galenic pharmacy.
A kind of pharmaceutical composition preventing and treating cervical cancer, it is characterised in that pharmaceutical composition and chemistry
What medicine or Chinese medicine formed prevents and treats cervical cancer medicine.
5. the preparation method of the pharmaceutical composition preventing and treating cervical cancer, it is characterised in that prepare as follows:
The composition of crude drug and weight portion be: northern bedstraw 306-310 weight portion Eucalyptus fruit 282-288 weight portion Lysimachia hemsleyana
10-14 weight portion Carnis Rallus aquaticus 162-164 weight portion Herba centaurll altaici 60-62 weight portion；
Preparation method:
(1) northern bedstraw, Eucalyptus fruit, Lysimachia hemsleyana, Carnis Rallus aquaticus, Herba centaurll altaici are taken by crude drug proportioning, mixing, use weight percent concentration
44% ethanol, as solvent, extracts at 26 DEG C of warm macerating, and extraction time is 28 times, and each extraction time is 28 hours, and each solvent is used
Amount is 53 times of crude drug gross weight, filters, obtains medicinal residues A and extracting solution A, extracting solution A and reclaim ethanol, be concentrated into relative density
1.07, filter, medicinal liquid passes through FU-01 macroporous adsorptive resins, first washes with water, more molten with weight percent concentration 35% ethanol
Liquid eluting FU-01 macroporous adsorptive resins, collection weight percent concentration 35% ethanol elution, recovery ethanol, concentrate drying,
Obtain extract A；
(2) take step (1) medicinal residues A, with weight percent concentration 82% ethanol as solvent, heating and refluxing extraction 15 times, carry every time
The time of taking is 0.1 hour, and each solvent load is 62 times of medicinal residues A weight, filters, obtains medicinal residues B and extracting solution B, and extracting solution B returns
Receiving ethanol, be concentrated into relative density 1.14, filter, medicinal liquid passes through SIP1200 macroporous adsorptive resins, first washes with water, then uses
Weight percent concentration 40.6% ethanol solution eluting SIP1200 macroporous adsorptive resins, collects weight percent concentration 40.6%
Ethanol elution, reclaims ethanol, concentrate drying, obtains extract B；
(3) extract A and extract B are mixed, obtain pharmaceutical composition.
The preparation method of a kind of pharmaceutical composition preventing and treating cervical cancer, it is characterised in that by as follows
Prepared by step:
The composition of crude drug and weight portion be: northern bedstraw 308 weight portion Eucalyptus fruit 285 weight portion Lysimachia hemsleyana 12 weight portions
Carnis Rallus aquaticus 163 weight portion Herba centaurll altaici 61 weight portion；
Preparation method:
(1) northern bedstraw, Eucalyptus fruit, Lysimachia hemsleyana, Carnis Rallus aquaticus, Herba centaurll altaici are taken by crude drug proportioning, mixing, use weight percent concentration
44% ethanol, as solvent, extracts at 26 DEG C of warm macerating, and extraction time is 28 times, and each extraction time is 28 hours, and each solvent is used
Amount is 53 times of crude drug gross weight, filters, obtains medicinal residues A and extracting solution A, extracting solution A and reclaim ethanol, be concentrated into relative density
1.07, filter, medicinal liquid passes through FU-01 macroporous adsorptive resins, first washes with water, more molten with weight percent concentration 35% ethanol
Liquid eluting FU-01 macroporous adsorptive resins, collection weight percent concentration 35% ethanol elution, recovery ethanol, concentrate drying,
Obtain extract A；
(2) take step (1) medicinal residues A, with weight percent concentration 82% ethanol as solvent, heating and refluxing extraction 15 times, carry every time
The time of taking is 0.1 hour, and each solvent load is 62 times of medicinal residues A weight, filters, obtains medicinal residues B and extracting solution B, and extracting solution B returns
Receiving ethanol, be concentrated into relative density 1.14, filter, medicinal liquid passes through SIP1200 macroporous adsorptive resins, first washes with water, then uses
Weight percent concentration 40.6% ethanol solution eluting SIP1200 macroporous adsorptive resins, collects weight percent concentration 40.6%
Ethanol elution, reclaims ethanol, concentrate drying, obtains extract B；
(3) extract A and extract B are mixed, obtain pharmaceutical composition.
The preparation method of a kind of pharmaceutical composition preventing and treating cervical cancer, it is characterised in that medicine group
Compound can use the conventional method of galenic pharmacy to be prepared as tablet or capsule or drop pill.
The preparation method of a kind of pharmaceutical composition preventing and treating cervical cancer, it is characterised in that medicine group
Compound prevents and treats cervical cancer medicine with chemical drugs or Chinese medicine composition.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201610501384.4A CN106038754A (en) | 2016-06-30 | 2016-06-30 | Medicine composition for preventing and treating cervical cancer and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610501384.4A CN106038754A (en) | 2016-06-30 | 2016-06-30 | Medicine composition for preventing and treating cervical cancer and preparation method thereof |
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| Publication Number | Publication Date |
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| CN106038754A true CN106038754A (en) | 2016-10-26 |
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ID=57201205
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| Application Number | Title | Priority Date | Filing Date |
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| Country | Link |
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| CN (1) | CN106038754A (en) |
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2016
- 2016-06-30 CN CN201610501384.4A patent/CN106038754A/en not_active Withdrawn
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Application publication date: 20161026 |