CN106822206A - It is a kind of to treat pharmaceutical composition of neurodermatitis and preparation method thereof - Google Patents
It is a kind of to treat pharmaceutical composition of neurodermatitis and preparation method thereof Download PDFInfo
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Abstract
Pharmaceutical composition of neurodermatitis and preparation method thereof is treated the invention discloses a kind of, pharmaceutical composition of the present invention is to dislike alkali, bright and beautiful vanilla, Oblongleaf Heterostemma, inulicin, polygalic acid, Corosolic acid as bulk drug with Chinese ephedra, proportioning is formed, routinely various formulations can be made by preparation process, treatment neurodermatitis is evident in efficacy.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicines, more particularly to a kind of pharmaceutical composition for treating neurodermatitis and its preparation
Method.
Background technology
Neurodermatitis, is a kind of common, multiple chronic dermatosis, with skin liver moss also known as lichen simplex chronicus
Sample becomes and acutely itch is characterized, and it is equivalent to the psoriasis or neurodermatitis in traditional Chinese medicine.The cause of disease of neurodermatitis not yet ten
Distinguish one from the other, but with nervous and mental factors have obvious relation, therefore western medical treatment with suit the medicine to the illness alleviate itch based on, orally with
Based on antihistamine drug, severe patient gives sedative hypnotics, outward to based on glucocorticoid medicine, though can respite disease
Feelings, but easily recurrence of being discontinued, and it is repeatedly larger using side effect.
The neurodermatitis doctor trained in Western medicine cause of disease is not very clear and definite, thus it is speculated that it is relevant that it is unbalance with dysfunction of nervous regulation, and traditional Chinese medical science pin
Moxibustion, herbal treatment have the advantages such as clinical efficacy is definite, rapid-action, adverse reaction is smaller, can rapidly alleviate local symptom, promote
Local skin damaged rapid regression；But Chinese medicine acupuncture, herbal treatment also have its weak point:As external preparation name it is lack of standardization,
Preparation technology is immature, without unified preparation for treating standard；Part document lacks the experimental studies such as pharmacology, toxicity without random controls
The problems such as；And tcm therapy treatment neurodermatitis mechanism of action is not yet fully aware of.Therefore, will be by after these are also
Step improves part, particularly acupuncture, Chinese medicine etc. for the research of the therapy mechanism of neurodermatitis and develops effective, safety
Treatment method or medicine, be dept. of dermatology clinical, the goal in research of researcher and direction.
Bright and beautiful vanilla：This product is Melastomataceae brocade vanilla platymiscium brocade vanilla Phyllagathis caualeriei
The herb or root of (Levl.et van.) Guill. [Allomorphia caualerieiLevl. Et van.].Spring, summer adopt
Grass is received, root whole year can be adopted, clean, and chopping is dried.【Nature and flavor】Bitter；It is pungent；It is cold in nature.【Indication】Clearing heat and cooling blood；Profit
It is wet.Main toxic-heat and blood stasis；Under humid tropics；Irregular menstruation；Metrorrhagia due to blood-heat；The hot hemorrhoid blood of intestines；Children's scrotum enlargement.【Former phytomorph】Grass
This, 10-15cm high.Stem is upright or crawls, and raw section by section very nearly meat is close by coarse wool long, four prismatics, generally not branch.Leaf pair
It is raw；Petiole 1.5-9cm long, it is close by coarse wool long；Blade papery, wide avette, oval or circle, the wide anxious point of tip to nearly circle
Shape, base portion is heart-shaped, 6-16cm long, 4.5-14cm wide, and two sides green or sometimes back side aubergine, surface are long thick by thin strigose shape
Hair, the back side only base goes out the coarse wool long that arteries and veins and lateral vein are flattened into；Base goes out arteries and veins 7-9, and surface arteries and veins is smooth, back side arteries and veins protuberance.Umbel,
Basidixed, total bennet 4-17cm long is dilute several without hair by coarse wool long；Bract obovate or nearside lanceolar, by coarse wool, generally only 4
Piece, 1cm is about, or it is longer；Bennet is with calyx by chaff；The prismatic of calyx funnel-form four, sliver is extensively avette；Petal pink is extremely
Purple, top is slightly biased tiltedly, the anxious point of tip；Stamen 4, near isometric, flower pesticide base portion tool tubercle or unobvious, connective is downward in short distance；
Ovary is cup-shaped, tip tool hat.Capsule, tip hat 4 splits, and stretches out persistent calyx, and persistent calyx has 8 longitudinal ribs, carpopodium elongation, by chaff.Flower
Month phase 6-8, the fruiting period 7-9 months.Record in dictionary of medicinal plant.
Oblongleaf Heterostemma：This product is dicotyledon medicine Asclepiadaceae Winged Heterostemma platymiscium Oblongleaf Heterostemma Hetrostemma
The complete stool of oblongifolium Cost..Autumn harvests, and dries.【Nature and flavor】It is slight bitter, sweet；It is flat.【Return through】Liver Channel.【Function master
Control】Lactagogue.Qi and blood stasis after main product；Agalactia.【Former phytomorph】Weak winding liana.Complete stool has milk, and stem is by 2 row
Pubescence.Leaf opposite；Petiole 2-4cm long；Blade Long Circle, dilute ovate Long Circle, 7.5-11cm long, 3.5-4.5cm wide, tip is sharp
Point, basal circular；Per side 5-7 bars, arc rises lateral vein.Umbrella shape shape cyme axillary, 2-3cm long is blossomed 4-5；Calyx 5
Drastic crack, inner face base portion has body of gland about 10；Corolla outside light green, inner face yellow, spoke shape, diameter 1-1.5cm；Corolla splits levies 5,
Cover to the right；Paracorolla five-pointed star aristiform, the every room 1 of massula, square circular, uprightly.Follicle radish fruit wire lanceolar, is up to
12cm, diameter about 1cm, it is tapering to tip.Seed is up to 2cm, about 3mm wide, white thin,tough silk matter kind hair of the seed tool up to 3cm.Flower
Month phase 8-10, the fruiting period 9-12 months.Record in dictionary of medicinal plant.
Chinese ephedra dislikes alkali（Ephedroxane ）：CAS 16251-46-0, molecular formula C11H13NO2, molecular weight 191.23.【Medicine
Reason is acted on】With antiinflammatory action.【Ingredient origin】Ephedraceae ephedra root.
Inulicin（Inulicin）：CAS 33627-41-7, molecular formula C17H24O5, molecular weight 308.37.【Medicine
Reason is acted on】Antiulcer, central nervous excitation agent.【Ingredient origin】Feverfew Inula britannica chinensis, inula lineariifolia, inula Britannica
Capitulum.
Polygalic acid（Polygalacic acid）：CAS 22338-71-2, molecular formula C30H48O6, molecular weight 504.70.
【Ingredient origin】Balloonflower root Platycodon grandiflorum.
Corosolic acid（Corosolic acid）：CAS 4547-24-4, molecular formula C30H48O4, molecular weight 472.70.【Into
Divide source】Red chopsticks Chamaenerion angustifolium [Syn.Epilobium angustifolium], three leaf rat-tails
Careless Salvia trijuga.
4 chemical constitutions of bulk drug：
Polygalic acid（Polygalacic acid）Chinese ephedra dislikes alkali（Ephedroxane ）
Inulicin（Inulicin）Corosolic acid（Corosolic acid）.
The content of the invention
The purpose of the present invention is to overcome the shortcomings of background technology, there is provided a kind of drug regimen of effective treatment neurodermatitis
Thing and preparation method thereof.
The present invention adopts the following technical scheme that realization：
The composition and weight portion for being made the bulk drug of the pharmaceutical composition of the treatment neurodermatitis be：
Chinese ephedra dislikes alkali 25-35 weight portions brocade vanilla 460-480 weight portion Oblongleaf Heterostemma 326-328 weight portion inulicins
8-10 weight portion polygalic acid 4-6 weight portion Corosolic acid 1-2 weight portions.
The pharmaceutical composition for the treatment of neurodermatitis is preferably used in, is made up of the bulk drug of following weight portion：
Chinese ephedra dislikes the weight portion polygala of 327 weight portion inulicin of the weight portion of alkali 30 brocade 470 weight portion Oblongleaf Heterostemma of vanilla 9
The sour weight portion of 5 weight portion Corosolic acid 1.5.
A kind of pharmaceutical composition for treating neurodermatitis, it is characterised in that pharmaceutical composition can be using the normal of galenic pharmacy
Rule method prepares piece agent or capsule or dripping pill.
A kind of pharmaceutical composition for treating neurodermatitis, it is characterised in that pharmaceutical composition is constituted with chemical drugs or Chinese medicine
Treatment neurodermatitis medicine.
A kind of preparation method of the pharmaceutical composition for treating neurodermatitis, it is characterised in that prepare as follows：
The composition and weight portion of bulk drug be：Chinese ephedra dislikes alkali 25-35 weight portions brocade vanilla 460-480 weight portion Oblongleaf Heterostemmas 326-
328 weight portion inulicin 8-10 weight portion polygalic acid 4-6 weight portion Corosolic acid 1-2 weight portions；
Preparation method：
（1）Chinese ephedra is taken by bulk drug proportioning and dislike alkali, bright and beautiful vanilla, Oblongleaf Heterostemma, inulicin, polygalic acid, Corosolic acid, mix
It is even, with the ethanol of weight percent concentration 35% as solvent, taken in 38.5 DEG C of temperature extractions, extraction time is 12 times, when extracting every time
Between be 1.5 hours, each solvent load is 21 times of bulk drug gross weight, filtration, obtains dregs of a decoction A and extract solution A, and extract solution A is returned
Ethanol is received, relative density 1.13 is concentrated into, filtered, liquid is first washed with water, then use weight by H-10 large pore resin absorption columns
The ethanol solution of percent concentration 48% elutes H-10 large pore resin absorption columns, collects the ethanol eluate of weight percent concentration 48%,
Ethanol is reclaimed, concentrate drying obtains final product extract A；
（2）Take step（1）Dregs of a decoction A, with the ethanol of weight percent concentration 54% as solvent, heating and refluxing extraction 12 times is carried every time
The time is taken for 0.1 hour, each solvent load is 18 times of dregs of a decoction A weight, and filtration obtains dregs of a decoction B and extract solution B, and extract solution B is returned
Ethanol is received, relative density 1.09 is concentrated into, filtered, liquid is first washed with water by LKS01 large pore resin absorption columns, then with again
Amount percent concentration 84% ethanol solution wash-out LKS01 large pore resin absorption columns, collect the ethanol elution of weight percent concentration 84%
Liquid, reclaims ethanol, and concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
Preferred a kind of preparation method of the pharmaceutical composition for treating neurodermatitis, it is characterised in that make as follows
It is standby：
The composition and weight portion of bulk drug be：Chinese ephedra dislikes the weight portion of 470 weight portion Oblongleaf Heterostemma of the weight portion of alkali 30 brocade vanilla 327
The weight portion of 9 weight portion polygalic acid of inulicin, 5 weight portion Corosolic acid 1.5；
Preparation method：
（1）Chinese ephedra is taken by bulk drug proportioning and dislike alkali, bright and beautiful vanilla, Oblongleaf Heterostemma, inulicin, polygalic acid, Corosolic acid, mix
It is even, with the ethanol of weight percent concentration 35% as solvent, taken in 38.5 DEG C of temperature extractions, extraction time is 12 times, when extracting every time
Between be 1.5 hours, each solvent load is 21 times of bulk drug gross weight, filtration, obtains dregs of a decoction A and extract solution A, and extract solution A is returned
Ethanol is received, relative density 1.13 is concentrated into, filtered, liquid is first washed with water, then use weight by H-10 large pore resin absorption columns
The ethanol solution of percent concentration 48% elutes H-10 large pore resin absorption columns, collects the ethanol eluate of weight percent concentration 48%,
Ethanol is reclaimed, concentrate drying obtains final product extract A；
（2）Take step（1）Dregs of a decoction A, with the ethanol of weight percent concentration 54% as solvent, heating and refluxing extraction 12 times is carried every time
The time is taken for 0.1 hour, each solvent load is 18 times of dregs of a decoction A weight, and filtration obtains dregs of a decoction B and extract solution B, and extract solution B is returned
Ethanol is received, relative density 1.09 is concentrated into, filtered, liquid is first washed with water by LKS01 large pore resin absorption columns, then with again
Amount percent concentration 84% ethanol solution wash-out LKS01 large pore resin absorption columns, collect the ethanol elution of weight percent concentration 84%
Liquid, reclaims ethanol, and concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
A kind of preparation method of the pharmaceutical composition for treating neurodermatitis, it is characterised in that pharmaceutical composition can be used
The conventional method of galenic pharmacy prepares piece agent or capsule or dripping pill.
A kind of preparation method of the pharmaceutical composition for treating neurodermatitis, it is characterised in that pharmaceutical composition and chemical drugs
Or Chinese medicine composition treatment neurodermatitis medicine.
Medicine composite for curing neurodermatitis is evident in efficacy.
Specific embodiment
Embodiment 1：Treat pharmaceutical composition of neurodermatitis and preparation method thereof
Treat neurodermatitis pharmaceutical composition bulk drug composition and weight portion be：Chinese ephedra dislikes alkali 30g brocade vanillas 470g
Oblongleaf Heterostemma 327g inulicin 9g polygalic acid 5g Corosolic acids 1.5g；
Preparation method：
（1）Chinese ephedra is taken by bulk drug proportioning and dislike alkali, bright and beautiful vanilla, Oblongleaf Heterostemma, inulicin, polygalic acid, Corosolic acid, mix
It is even, with the ethanol of weight percent concentration 35% as solvent, taken in 38.5 DEG C of temperature extractions, extraction time is 12 times, when extracting every time
Between be 1.5 hours, each solvent load is 21 times of bulk drug gross weight, filtration, obtains dregs of a decoction A and extract solution A, and extract solution A is returned
Ethanol is received, relative density 1.13 is concentrated into, filtered, liquid is first washed with water, then use weight by H-10 large pore resin absorption columns
The ethanol solution of percent concentration 48% elutes H-10 large pore resin absorption columns, collects the ethanol eluate of weight percent concentration 48%,
Ethanol is reclaimed, concentrate drying obtains final product extract A；
（2）Take step（1）Dregs of a decoction A, with the ethanol of weight percent concentration 54% as solvent, heating and refluxing extraction 12 times is carried every time
The time is taken for 0.1 hour, each solvent load is 18 times of dregs of a decoction A weight, and filtration obtains dregs of a decoction B and extract solution B, and extract solution B is returned
Ethanol is received, relative density 1.09 is concentrated into, filtered, liquid is first washed with water by LKS01 large pore resin absorption columns, then with again
Amount percent concentration 84% ethanol solution wash-out LKS01 large pore resin absorption columns, collect the ethanol elution of weight percent concentration 84%
Liquid, reclaims ethanol, and concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
Embodiment 2：Treat pharmaceutical composition of neurodermatitis and preparation method thereof
Treat neurodermatitis pharmaceutical composition bulk drug composition and weight portion be：Chinese ephedra dislikes alkali 25g brocade vanillas 480g
Oblongleaf Heterostemma 326g inulicin 10g polygalic acid 4g Corosolic acids 2g；
Preparation method：
（1）Chinese ephedra is taken by bulk drug proportioning and dislike alkali, bright and beautiful vanilla, Oblongleaf Heterostemma, inulicin, polygalic acid, Corosolic acid, mix
It is even, with the ethanol of weight percent concentration 35% as solvent, taken in 38.5 DEG C of temperature extractions, extraction time is 12 times, when extracting every time
Between be 1.5 hours, each solvent load is 21 times of bulk drug gross weight, filtration, obtains dregs of a decoction A and extract solution A, and extract solution A is returned
Ethanol is received, relative density 1.13 is concentrated into, filtered, liquid is first washed with water, then use weight by H-10 large pore resin absorption columns
The ethanol solution of percent concentration 48% elutes H-10 large pore resin absorption columns, collects the ethanol eluate of weight percent concentration 48%,
Ethanol is reclaimed, concentrate drying obtains final product extract A；
（2）Take step（1）Dregs of a decoction A, with the ethanol of weight percent concentration 54% as solvent, heating and refluxing extraction 12 times is carried every time
The time is taken for 0.1 hour, each solvent load is 18 times of dregs of a decoction A weight, and filtration obtains dregs of a decoction B and extract solution B, and extract solution B is returned
Ethanol is received, relative density 1.09 is concentrated into, filtered, liquid is first washed with water by LKS01 large pore resin absorption columns, then with again
Amount percent concentration 84% ethanol solution wash-out LKS01 large pore resin absorption columns, collect the ethanol elution of weight percent concentration 84%
Liquid, reclaims ethanol, and concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
Embodiment 3：Treat pharmaceutical composition of neurodermatitis and preparation method thereof
Treat neurodermatitis pharmaceutical composition bulk drug composition and weight portion be：Chinese ephedra dislikes alkali 35g brocade vanillas 460g
Oblongleaf Heterostemma 328g inulicin 8g polygalic acid 6g Corosolic acids 1g；
Preparation method：
（1）Chinese ephedra is taken by bulk drug proportioning and dislike alkali, bright and beautiful vanilla, Oblongleaf Heterostemma, inulicin, polygalic acid, Corosolic acid, mix
It is even, with the ethanol of weight percent concentration 35% as solvent, taken in 38.5 DEG C of temperature extractions, extraction time is 12 times, when extracting every time
Between be 1.5 hours, each solvent load is 21 times of bulk drug gross weight, filtration, obtains dregs of a decoction A and extract solution A, and extract solution A is returned
Ethanol is received, relative density 1.13 is concentrated into, filtered, liquid is first washed with water, then use weight by H-10 large pore resin absorption columns
The ethanol solution of percent concentration 48% elutes H-10 large pore resin absorption columns, collects the ethanol eluate of weight percent concentration 48%,
Ethanol is reclaimed, concentrate drying obtains final product extract A；
（2）Take step（1）Dregs of a decoction A, with the ethanol of weight percent concentration 54% as solvent, heating and refluxing extraction 12 times is carried every time
The time is taken for 0.1 hour, each solvent load is 18 times of dregs of a decoction A weight, and filtration obtains dregs of a decoction B and extract solution B, and extract solution B is returned
Ethanol is received, relative density 1.09 is concentrated into, filtered, liquid is first washed with water by LKS01 large pore resin absorption columns, then with again
Amount percent concentration 84% ethanol solution wash-out LKS01 large pore resin absorption columns, collect the ethanol elution of weight percent concentration 84%
Liquid, reclaims ethanol, and concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
Embodiment 4：The preparation of tablet
The pharmaceutical composition 238g of Example 1, adds starch 115g, mixes, and granulation is dried, plus microcrystalline cellulose 72g, stearic
Sour magnesium 4g, mixes, and is pressed into 1100, obtains final product medicinal composition tablets.
Embodiment 5：The preparation of capsule
The pharmaceutical composition 443g of Example 2, adds starch 280g, mixes, and granulation is dried, whole grain, adds appropriate stearic acid
Magnesium, mixes, and encapsulated 2000, obtains final product medicament composition capsule.
Embodiment 6：The preparation of dripping pill
Weigh (80 DEG C) heating of Macrogol 6000 120g water-baths and boil molten, add the pharmaceutical composition 10g of embodiment 3, fully stir
Mix uniform, with atoleine as cooling agent, put glass tube（4*80cm）In, chilling temperature is -1 DEG C, and drip internal-and external diameter is 7.0/
2.0 (mm/mm), drip is 2.0cm away from liquid level, and drop speed is optimum condition with every point 40 drop, and the cold of dripping pill surface is blotted with cotton
Solidifying agent, obtains final product medicament composition dropping pills.
Embodiment 7：Treat the pharmaceutical composition of neurodermatitis
Treat neurodermatitis pharmaceutical composition bulk drug composition and weight portion be：
Chinese ephedra dislikes the weight portion of 30 weight portion Corosolic acid of alkali 20 weight portion inulicin, 20 weight portion polygalic acid 10.
Embodiment 8：Treat the pharmaceutical composition of neurodermatitis
Treat neurodermatitis pharmaceutical composition bulk drug composition and weight portion be：
Chinese ephedra dislikes the weight portion of 25 weight portion Corosolic acid of alkali 30 weight portion inulicin, 10 weight portion polygalic acid 12.
Embodiment 9：Treat the pharmaceutical composition of neurodermatitis
Treat neurodermatitis pharmaceutical composition bulk drug composition and weight portion be：
Chinese ephedra dislikes the weight portion of 10 weight portion Corosolic acid of alkali 23 weight portion inulicin, 50 weight portion polygalic acid 8.
Experimental example 1：Treat the experimental study of neurodermatitis
1.1 physical data
This group 40, man 16, female 24；Between age 21-45 Sui；The course of disease -10 years 1 year, average 3.4 years.Wherein, limitation
Neurodermatitis 26, disseminated neurodermatitis 14.There is lichenification in local neurodermatitis, is mainly in neck four
Limb, summer is multiple.Disseminated neurodermatitis skin damaged is widely distributed and disperse, has scratch skin damaged, in paroxysmal itching, night more
More so.
1.2 diagnostic criteria
Skin damaged feature:, to the big papule of mung bean, top is flat, rounded or polygonal, more in light red, yellowish-brown or normal for grain grain
Color of the leather, or have pigmentation, the white scales of skin that peel off can be covered.Distribution often is dispersed in, or intensive is fused into patch, or lichenification.Patch side
Boundary understands, differs in size, and can be circular, similar round or not shaping, and surrounding can also have a small number of isolated flat papules being dispersed in.
Position:It is located at the portions such as after neck and both sides, the fossa cubitalis, nest, stock inner side, tail sacrum and wrist, ankle, other positions can also be sent out more
It is raw.
Local neurodermatitis:Fash is not very extensive or is only limitted to above-mentioned position person.
Generalized neurodermatitis:In addition to above-mentioned position, one of eyelid, scalp, trunk and four limbs portion or big portion affected individual.
2 treatment methods
2.1 Chinese medicine groups
Totally 20, using combination of oral medication（The pharmaceutical composition of embodiment 1）.Each 1.2g, 3 times a day.It is within 4 weeks a treatment
Journey, observes curative effect after 4 weeks, the regulation of feelings will is noted during medication, does not eat pungent, avoids tobacco and wine, preferably wears pure cotton clothes etc..
2.2 control groups
Totally 20, using oral vitamin C 0.3g, 3 times a day；Vitamin B compound 2,3 times a day.It is within 4 weeks a treatment
Journey, points for attention are with Chinese medicine group during curative effect, medication are observed after 4 weeks.
3 treatment results
3.1 criterions of therapeutical effect
Clinical cure:Skin damaged is whole to disappear, and scratchiness disappears, more afterwards in 3 months without recurrence；
It is effective:Skin damaged is most of to disappear, and itch substantially mitigates.
Effectively:Skin damaged partial remission, pruritis make moderate progress；
It is invalid:Skin damaged disappears not substantially, and itch has no that mitigation or clinical symptoms deteriorate on the contrary.
3.2 treatment results
In treatment group 20, cure 10, take a turn for the better（Effective+effectively）8, invalid 2, total effective rate 90.00%.Control group 20
In example, cure 2, take a turn for the better（Effective+effectively）8, invalid 10, total effective rate 50.00%.Through statistics Chi-square Test, two groups
More there is significant difference (P<0.01).It is indicated above, pharmaceutical composition has obvious therapeutic action to neurodermatitis, controls
There is not obvious adverse drug reaction after treatment group and control group medication.
4 medical records are illustrated
King so-and-so, women, 39 years old, workman.Because of nearly 2 years of whole skin itch, inspection was shown in:The multiple gathering papule of whole body, in circle
Shape or polygonal, filbert, surface is coated with the white scales of skin that peel off, the visible scratch of surrounding and scab, is mainly in four limbs, chest and back.Companion
There is bitter taste, stool knot, tongue is red, yellow tongue fur, veins is sliding.Once injection dexamethasone, calcium gluconae before medical, oral Astemizole, open auspicious
It is smooth to wait medicine.Aggravate after menstruation and after the seafood such as fishes and shrimps of taking food, according to symptom and skin damaged situation, be diagnosed as neurodermatitis.Mouthful
Medication compositions（The pharmaceutical composition of embodiment 1）.Each 1.2g, 3 times a day.4 weeks is a course for the treatment of, and curative effect is observed after 4 weeks,
The regulation of feelings will is noted during medication, does not eat pungent, avoid tobacco and wine, wear pure cotton clothes.Treatment January, skin damaged and papule disappear, after half a year
Follow-up, no relapse.
Claims (8)
1. a kind of pharmaceutical composition for treating neurodermatitis, it is characterised in that be made the composition of the bulk drug of the pharmaceutical composition
It is with weight portion：
Chinese ephedra dislikes alkali 25-35 weight portions brocade vanilla 460-480 weight portion Oblongleaf Heterostemma 326-328 weight portion inulicins
8-10 weight portion polygalic acid 4-6 weight portion Corosolic acid 1-2 weight portions.
2. a kind of pharmaceutical composition for treating neurodermatitis according to claim 1, it is characterised in that be made the medicine group
The composition and weight portion of the bulk drug of compound be：
Chinese ephedra dislikes the weight portion polygala of 327 weight portion inulicin of the weight portion of alkali 30 brocade 470 weight portion Oblongleaf Heterostemma of vanilla 9
The sour weight portion of 5 weight portion Corosolic acid 1.5.
3. a kind of pharmaceutical composition for treating neurodermatitis according to claim 1, it is characterised in that pharmaceutical composition can
Piece agent or capsule or dripping pill are prepared with using the conventional method of galenic pharmacy.
4. a kind of pharmaceutical composition for treating neurodermatitis according to claim 1, it is characterised in that pharmaceutical composition with
The treatment neurodermatitis medicine of chemical drugs or Chinese medicine composition.
5. a kind of preparation method of the pharmaceutical composition for treating neurodermatitis, it is characterised in that prepare as follows：
The composition and weight portion of bulk drug be：Chinese ephedra dislikes alkali 25-35 weight portions brocade vanilla 460-480 weight portion Oblongleaf Heterostemmas 326-
328 weight portion inulicin 8-10 weight portion polygalic acid 4-6 weight portion Corosolic acid 1-2 weight portions；
Preparation method：
（1）Chinese ephedra is taken by bulk drug proportioning and dislike alkali, bright and beautiful vanilla, Oblongleaf Heterostemma, inulicin, polygalic acid, Corosolic acid, mix
It is even, with the ethanol of weight percent concentration 35% as solvent, taken in 38.5 DEG C of temperature extractions, extraction time is 12 times, when extracting every time
Between be 1.5 hours, each solvent load is 21 times of bulk drug gross weight, filtration, obtains dregs of a decoction A and extract solution A, and extract solution A is returned
Ethanol is received, relative density 1.13 is concentrated into, filtered, liquid is first washed with water, then use weight by H-10 large pore resin absorption columns
The ethanol solution of percent concentration 48% elutes H-10 large pore resin absorption columns, collects the ethanol eluate of weight percent concentration 48%,
Ethanol is reclaimed, concentrate drying obtains final product extract A；
（2）Take step（1）Dregs of a decoction A, with the ethanol of weight percent concentration 54% as solvent, heating and refluxing extraction 12 times is carried every time
The time is taken for 0.1 hour, each solvent load is 18 times of dregs of a decoction A weight, and filtration obtains dregs of a decoction B and extract solution B, and extract solution B is returned
Ethanol is received, relative density 1.09 is concentrated into, filtered, liquid is first washed with water by LKS01 large pore resin absorption columns, then with again
Amount percent concentration 84% ethanol solution wash-out LKS01 large pore resin absorption columns, collect the ethanol elution of weight percent concentration 84%
Liquid, reclaims ethanol, and concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
6. a kind of preparation method of the pharmaceutical composition for treating neurodermatitis according to claim 5, it is characterised in that press
It is prepared by following steps：
The composition and weight portion of bulk drug be：Chinese ephedra dislikes the weight portion of 470 weight portion Oblongleaf Heterostemma of the weight portion of alkali 30 brocade vanilla 327
The weight portion of 9 weight portion polygalic acid of inulicin, 5 weight portion Corosolic acid 1.5；
Preparation method：
（1）Chinese ephedra is taken by bulk drug proportioning and dislike alkali, bright and beautiful vanilla, Oblongleaf Heterostemma, inulicin, polygalic acid, Corosolic acid, mix
It is even, with the ethanol of weight percent concentration 35% as solvent, taken in 38.5 DEG C of temperature extractions, extraction time is 12 times, when extracting every time
Between be 1.5 hours, each solvent load is 21 times of bulk drug gross weight, filtration, obtains dregs of a decoction A and extract solution A, and extract solution A is returned
Ethanol is received, relative density 1.13 is concentrated into, filtered, liquid is first washed with water, then use weight by H-10 large pore resin absorption columns
The ethanol solution of percent concentration 48% elutes H-10 large pore resin absorption columns, collects the ethanol eluate of weight percent concentration 48%,
Ethanol is reclaimed, concentrate drying obtains final product extract A；
（2）Take step（1）Dregs of a decoction A, with the ethanol of weight percent concentration 54% as solvent, heating and refluxing extraction 12 times is carried every time
The time is taken for 0.1 hour, each solvent load is 18 times of dregs of a decoction A weight, and filtration obtains dregs of a decoction B and extract solution B, and extract solution B is returned
Ethanol is received, relative density 1.09 is concentrated into, filtered, liquid is first washed with water by LKS01 large pore resin absorption columns, then with again
Amount percent concentration 84% ethanol solution wash-out LKS01 large pore resin absorption columns, collect the ethanol elution of weight percent concentration 84%
Liquid, reclaims ethanol, and concentrate drying obtains final product extract B；
（3）Extract A and extract B are mixed, pharmaceutical composition is obtained final product.
7. a kind of preparation method of the pharmaceutical composition for treating neurodermatitis according to claim 5, it is characterised in that medicine
Compositions can prepare piece agent or capsule or dripping pill using the conventional method of galenic pharmacy.
8. a kind of preparation method of the pharmaceutical composition for treating neurodermatitis according to claim 5, it is characterised in that medicine
Compositions and chemical drugs or Chinese medicine composition treatment neurodermatitis medicine.
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| CN201611133193.3A CN106822206A (en) | 2016-12-10 | 2016-12-10 | It is a kind of to treat pharmaceutical composition of neurodermatitis and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019011293A1 (en) * | 2017-07-13 | 2019-01-17 | 华东理工大学 | Saponin compound targeting pd-1 and application thereof |
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2016
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019011293A1 (en) * | 2017-07-13 | 2019-01-17 | 华东理工大学 | Saponin compound targeting pd-1 and application thereof |
| GB2578390A (en) * | 2017-07-13 | 2020-05-06 | Univ East China Science & Tech | Saponin compound targeting PD-1 and application thereof |
| GB2578390B (en) * | 2017-07-13 | 2022-08-31 | Univ East China Science & Tech | Saponin compound targeting PD-1 and application thereof |
| US11464795B2 (en) | 2017-07-13 | 2022-10-11 | East China University Of Science And Technology | Saponin compound targeting PD-1 and application thereof |
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