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CN105535486A - Medicine for treating liver depression and qi stagnation type postpartum hypogalactia and preparation method thereof - Google Patents

Medicine for treating liver depression and qi stagnation type postpartum hypogalactia and preparation method thereof Download PDF

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Publication number
CN105535486A
CN105535486A CN201610001369.3A CN201610001369A CN105535486A CN 105535486 A CN105535486 A CN 105535486A CN 201610001369 A CN201610001369 A CN 201610001369A CN 105535486 A CN105535486 A CN 105535486A
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radix
medicine
herba
rhizoma
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许文
吕明云
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Jinan Situo Xinyuan Pharmaceutical Technology Co Ltd
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Jinan Situo Xinyuan Pharmaceutical Technology Co Ltd
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    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/898—Orchidaceae (Orchid family)
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    • A61K36/18—Magnoliophyta (angiosperms)
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Abstract

The invention discloses a medicine for treating liver depression and qi stagnation type postpartum hypogalactia and a preparation method thereof. The medicine is prepared from pericarpium citri reticulatae viride, lychee seeds, rhizoma cyperi, fructus citri sarcodactylis, fructus citri, flos rosae rugosae, dried buds of prunus mume Sieb. et Zucc., semen aesculi, herba aristolochiae, rhizoma corydalis decumbentis, herba leonuri, herba lycopi, caulis spatholobi, cowherb seeds, valerian roots, cortex albiziae, radix codonopsis, radix astragali, rhizoma dioscoreae, rhodiola rosea, fructus hippophae, herb of twoflower micromeria, lily, radix ophiopogonis and herb of goodyera kwangtungensis. The medicine has the advantages that the main purposes of relieving the depressed liver and activating collaterals for promoting lactation are achieved based on the theory of traditional Chinese medicine, and the medicine is mainly used for treating liver depression and qi stagnation type postpartum hypogalactia and is capable of taking effect fast, definite in treatment effect, high in safety, free of toxic and side effects and capable of ensuring that relapse is not likely to occur.

Description

For the medicine and preparation method thereof of caused by hepatic stagnation qi stagnation hypogalactia in puerperal
This case is divisional application, and the denomination of invention of original application is: for the pharmaceutical composition and preparation method thereof of caused by hepatic stagnation qi stagnation hypogalactia in puerperal, the applying date of original application is: 2014-05-12, and the application number of original application is: 201410195317.5.
Technical field
The present invention relates to pharmaceutical technology, particularly relate to a kind of for puerperal caused by hepatic stagnation qi stagnation hypogalactia medicine and preparation method.
Background technology
Puerpera when suckling milk very less or completely without, enough even can feeding infant person, be called puerperal hypogalactia.Degree and the situation of hypogalactia are different: lack during the beginning suckling had, later slightly many but still inadequate; Have completely without milk, can not breast be fed completely; The normal suckling had, high heat or seven emotions are crossed extremely suddenly, and milk is suddenly few, is not enough to feeding infant.
Clinical symptoms: mostly occur 2-3 days puerperal in two weeks.Galactopoiesis, except closely related with development of breast, sucks stimulation when depending on suckling to a great extent.In addition, closely related with the nutrition of puerpera, sleep, health status and emotion.
Chinese medicine is thought, between age of sucking, puerpera's milk very less or completely without, be called " hypogalactia ", also known as " galactozemia " or " hypogalactia ".Common typing has deficient qi and blood and stagnation of QI due to depression of the liver.Weak type of qi and blood: ferritic deficient qi and blood, multiple because of consumption gas of losing blood when producing, deficiency of qi and blood, or weakness of the spleen and stomach, insufficiency of generating and transforming QI and blood, so that being difficult of deficient qi and blood is newborn, then puerperal milk very less or completely without.Caused by hepatic stagnation qi stagnation: the damaged by excess of seven emotions of depression, or puerperal without hesitation, liver is lost bar and reaches, functional activity of QI being not smooth, disorder of QI and blood, so that passages through which vital energy circulates is not smooth, hinders milk to run, thus hypogalactia.Wherein, the main syndromes of caused by hepatic stagnation qi stagnation is: puerperal, milk was puckery few, dense thick, or agalactia, the hard pain of mammary swelling, depressed emotion, and breast side of body feeling of distension and oppression, inappetence, or slight fever, body of the tongue is normal, yellow and thin fur, stringy and thready pulse or stringy and rapid pulse.
Breast milk is baby development the most natural, the safest, most complete unique natural food.It contains the nutritious and antibody needed for baby development, particularly breast milk contains the fat of 50 percent, except supply baby body heat, also meet the fat (structure of brain 60 percent comes from fat) needed for baby's brain development; Abundant calcium and phosphorus can make the long height of baby strengthen again; Immunoglobulin can effectively prevent and protect baby to avoid the generation of infection and chronic disease; Than have to can suppress intestinal pathogenic bacteria hypertrophy and help digest by Summing Factor oligosaccharide.In addition, intimate contact and the paternity of feeding breast milk can stimulate baby's brain and mental development, feed breast milk simultaneously and can promote mother's uterine contraction again, keep good stature, so feeding breast milk is have very large benefit to baby and mother.
But western medical treatment puerperal hypogalactia, still lacks clinical treatment medicine effectively at present, Chinese medicine have accumulated abundant clinical experience and therapy theory in control puerperal hypogalactia.Clinical market has had the Chinese Traditional Medicines of multiple control puerperal hypogalactia, but, clinical symptoms, the sign different according to patient, different individual body constitution, existing Chinese Traditional Medicines are also not enough to the demand meeting clinical market, and this just needs production one can for specific clinical manifestation, specific clinical disease typing, carry out magnetic target therapy, the significant new drug of clinical efficacy.
Summary of the invention
Technical problem to be solved by this invention is, there is provided a kind of and be used for the treatment of medicine of caused by hepatic stagnation qi stagnation hypogalactia in puerperal and preparation method thereof, this medicine is based on dispersing the stagnated live-QI to relieve the stagnation of QI, active lactogenesis, and treatment caused by hepatic stagnation qi stagnation hypogalactia in puerperal has the advantage that rapid-action, determined curative effect, safety are high, have no side effect and not easily recur.
In order to solve the problems of the technologies described above, the invention provides a kind of medicine being used for the treatment of caused by hepatic stagnation qi stagnation hypogalactia in puerperal, wherein, following raw medicinal material is comprised: Pericarpium Citri Reticulatae Viride, Semen Litchi, Rhizoma Cyperi, Fructus Citri Sarcodactylis, Fructus Citri, Flos Rosae Rugosae, FLOS MUME, Semen Aesculi, Herba Aristolochiae, Rhizoma Corydalis Decumbentis, Herba Leonuri, Herba Lycopi, Caulis Spatholobi, Semen Vaccariae, Rhizoma et radix valerianae, Cortex Albiziae, Radix Codonopsis, the Radix Astragali, Rhizoma Dioscoreae, Radix Rhodiolae, Fructus Hippophae, Herba Micromeriae Biflorae, Bulbus Lilii, Radix Ophiopogonis and Oxyria sinensis Hemsl..
In described medicine, the parts by weight of each raw medicinal material are preferably: Pericarpium Citri Reticulatae Viride 10-20 weight portion, Semen Litchi 10-20 weight portion, Rhizoma Cyperi 15-25 weight portion, Fructus Citri Sarcodactylis 10-20 weight portion, Fructus Citri 10-20 weight portion, Flos Rosae Rugosae 10-20 weight portion, FLOS MUME 10-20 weight portion, Semen Aesculi 15-25 weight portion, Herba Aristolochiae 10-20 weight portion, Rhizoma Corydalis Decumbentis 10-15 weight portion, Herba Leonuri 15-25 weight portion, Herba Lycopi 15-25 weight portion, Caulis Spatholobi 10-20 weight portion, Semen Vaccariae 5-15 weight portion, Rhizoma et radix valerianae 10-20 weight portion, Cortex Albiziae 10-20 weight portion, Radix Codonopsis 10-20 weight portion, Radix Astragali 15-25 weight portion, Rhizoma Dioscoreae 15-25 weight portion, Radix Rhodiolae 5-10 weight portion, Fructus Hippophae 10-20 weight portion, Herba Micromeriae Biflorae 10-20 weight portion, Bulbus Lilii 15-25 weight portion, Radix Ophiopogonis 10-20 weight portion and Oxyria sinensis Hemsl. 10-20 weight portion.
In described medicine, the parts by weight of each raw medicinal material also can be preferably: Pericarpium Citri Reticulatae Viride 15 weight portion, Semen Litchi 16 weight portion, Rhizoma Cyperi 21 weight portion, Fructus Citri Sarcodactylis 15 weight portion, Fructus Citri 15 weight portion, Flos Rosae Rugosae 15 weight portion, FLOS MUME 13 weight portion, Semen Aesculi 17 weight portion, Herba Aristolochiae 14 weight portion, Rhizoma Corydalis Decumbentis 12 weight portion, Herba Leonuri 20 weight portion, Herba Lycopi 19 weight portion, Caulis Spatholobi 15 weight portion, Semen Vaccariae 8 weight portion, Rhizoma et radix valerianae 15 weight portion, Cortex Albiziae 12 weight portion, Radix Codonopsis 16 weight portion, the Radix Astragali 20 weight portion, Rhizoma Dioscoreae 20 weight portion, Radix Rhodiolae 7 weight portion, Fructus Hippophae 15 weight portion, Herba Micromeriae Biflorae 15 weight portion, Bulbus Lilii 21 weight portion, Radix Ophiopogonis 15 weight portion and Oxyria sinensis Hemsl. 15 weight portion.
Described medicine also comprises: Rhizoma alpiniae pumilae, volume stem knotweed, Radix Oryzae Glutinosae, Folium Fumicis Dentati and Herba Hemisteptae Lyratae.
In described medicine, the parts by weight of each raw medicinal material are preferably: Pericarpium Citri Reticulatae Viride 10-20 weight portion, Semen Litchi 10-20 weight portion, Rhizoma Cyperi 15-25 weight portion, Fructus Citri Sarcodactylis 10-20 weight portion, Fructus Citri 10-20 weight portion, Flos Rosae Rugosae 10-20 weight portion, FLOS MUME 10-20 weight portion, Semen Aesculi 15-25 weight portion, Herba Aristolochiae 10-20 weight portion, Rhizoma Corydalis Decumbentis 10-15 weight portion, Herba Leonuri 15-25 weight portion, Herba Lycopi 15-25 weight portion, Caulis Spatholobi 10-20 weight portion, Semen Vaccariae 5-15 weight portion, Rhizoma et radix valerianae 10-20 weight portion, Cortex Albiziae 10-20 weight portion, Radix Codonopsis 10-20 weight portion, Radix Astragali 15-25 weight portion, Rhizoma Dioscoreae 15-25 weight portion, Radix Rhodiolae 5-10 weight portion, Fructus Hippophae 10-20 weight portion, Herba Micromeriae Biflorae 10-20 weight portion, Bulbus Lilii 15-25 weight portion, Radix Ophiopogonis 10-20 weight portion, Oxyria sinensis Hemsl. 10-20 weight portion, Rhizoma alpiniae pumilae 10-20 weight portion, volume stem knotweed 15-25 weight portion, Radix Oryzae Glutinosae 10-20 weight portion, Folium Fumicis Dentati 10-20 weight portion and Herba Hemisteptae Lyratae 15-25 weight portion.
In described medicine, the parts by weight of each raw medicinal material can also be preferably: Pericarpium Citri Reticulatae Viride 15 weight portion, Semen Litchi 16 weight portion, Rhizoma Cyperi 21 weight portion, Fructus Citri Sarcodactylis 15 weight portion, Fructus Citri 15 weight portion, Flos Rosae Rugosae 15 weight portion, FLOS MUME 13 weight portion, Semen Aesculi 17 weight portion, Herba Aristolochiae 14 weight portion, Rhizoma Corydalis Decumbentis 12 weight portion, Herba Leonuri 20 weight portion, Herba Lycopi 19 weight portion, Caulis Spatholobi 15 weight portion, Semen Vaccariae 8 weight portion, Rhizoma et radix valerianae 15 weight portion, Cortex Albiziae 12 weight portion, Radix Codonopsis 16 weight portion, the Radix Astragali 20 weight portion, Rhizoma Dioscoreae 20 weight portion, Radix Rhodiolae 7 weight portion, Fructus Hippophae 15 weight portion, Herba Micromeriae Biflorae 15 weight portion, Bulbus Lilii 21 weight portion, Radix Ophiopogonis 15 weight portion, Oxyria sinensis Hemsl. 15 weight portion, Rhizoma alpiniae pumilae 15 weight portion, volume stem knotweed 21 weight portion, Radix Oryzae Glutinosae 15 weight portion, Folium Fumicis Dentati 15 weight portion and Herba Hemisteptae Lyratae 19 weight portion.
In order to better realize foregoing invention object, present invention also offers a kind of preparation method being used for the treatment of the medicine of caused by hepatic stagnation qi stagnation hypogalactia in puerperal, the dosage form of described medicine is tablet, and described preparation method comprises the following steps:
The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 4 ~ 5 times is the ethanol of 85% ~ 90%, reflux 2 ~ 4 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 90% ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 2 ~ 3 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 2 ~ 3 hours, pulverize, sieve, obtain 300 order ~ 400 object micropowders;
3rd step, by the micropowders that second step obtains, add relative to the microcrystalline Cellulose of its quality 0.1 ~ 0.3 times, 0.15 ~ 0.3 times of lactose, the starch of 0.2 ~ 0.35 times, sieve, mix homogeneously, granulate, drying, adds relative to micropowders quality 0.025 ~ 0.04 times of magnesium stearate, granulate, tabletting, makes.
When the dosage form of described medicine is injection, described preparation method comprises the following steps:
The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 0.1 ~ 10 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 95%;
Second step, adding relative to the determining alcohol of the quality 3 ~ 5 times of described mixed powder in the mixed powder that the first step obtains is the ethanol of 85% ~ 95%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 24 ~ 36 hours under the condition of 5 DEG C ~ 10 DEG C, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, concentrated and dry, and put into super micron mill pulverizing 40 ~ 60 minutes at this, the micron particles of acquisition 0.1 ~ 10 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,
3rd step, gets mixed powder 10g ~ 20g that second step obtains, adds propylene glycol 30g ~ 50g, add 200ml water for injection, stirs and makes it dissolve, inject water to 1000ml further, then add 1g ~ 1.5g needle-use activated carbon, fully stir 30 ~ 50 minutes; Decarbonization filtering; With 0.22 ~ 0.24 μm of filtering with microporous membrane; Lyophilization obtains sterilized powder, subpackage embedding.
When the dosage form of described medicine is liniment, described preparation method comprises the following steps:
Step one: first described raw medicinal material is ground into coarse powder, then pulverizes further, cross 100 mesh sieves, the enable fine powder amount by 100 mesh sieves at least reaches 40%, collects and obtains fine powder a by the fine powder of 100 mesh sieves;
Step 2: the coarse powder not by 100 mesh sieves is dropped into multi-function extractor and extracts twice, first time adds weight portion 8-10 times amount soak by water 1-3 hour, and second time adds weight portion 6-10 times amount soak by water 1-3 hour, merges twice decocting liquid, filters to get filtrate; The heating of gained filtrate is concentrated into pasty state, and after putting into the oven dry of 80 DEG C, baking oven, room temperature cools, and grinds to form fine powder b;
Step 3: call in glycerol after being mixed with fine powder b by fine powder a and make liniment.
The invention has the beneficial effects as follows: medicine of the present invention, utilize the theory of Chinese medical science that China is traditional, based on dispersing the stagnated live-QI to relieve the stagnation of QI, active lactogenesis, cure mainly caused by hepatic stagnation qi stagnation hypogalactia in puerperal, there is the advantage that rapid-action, determined curative effect, safety are high, have no side effect and not easily recur.
Detailed description of the invention
The invention provides a kind of medicine being used for the treatment of caused by hepatic stagnation qi stagnation hypogalactia in puerperal, wherein, following raw medicinal material is comprised: Pericarpium Citri Reticulatae Viride, Semen Litchi, Rhizoma Cyperi, Fructus Citri Sarcodactylis, Fructus Citri, Flos Rosae Rugosae, FLOS MUME, Semen Aesculi, Herba Aristolochiae, Rhizoma Corydalis Decumbentis, Herba Leonuri, Herba Lycopi, Caulis Spatholobi, Semen Vaccariae, Rhizoma et radix valerianae, Cortex Albiziae, Radix Codonopsis, the Radix Astragali, Rhizoma Dioscoreae, Radix Rhodiolae, Fructus Hippophae, Herba Micromeriae Biflorae, Bulbus Lilii, Radix Ophiopogonis and Oxyria sinensis Hemsl.; Preferably, described medicine also comprises: Rhizoma alpiniae pumilae, volume stem knotweed, Radix Oryzae Glutinosae, Folium Fumicis Dentati and Herba Hemisteptae Lyratae.
The pharmacological property of above-mentioned raw materials medical material is as follows:
Pericarpium Citri Reticulatae Viride: nature and flavor toil, temperature.Enter liver, gallbladder, stomach warp.Can soothing the liver dispelling the stagnated QI, removing food stagnancyization stagnant.For costa sternales gastral cavity distending pain, acute mastitis, colic, stagnation of QI due to dyspepsia.Modern pharmacology experimentation shows: Pericarpium Citri Reticulatae Viride injection can reduce the tonic contraction of isolated guinea pig stomach, intestinal, gallbladder and Mouse Uterus, and makes smooth muscle of bladder excited.The gallbladder contraction that the guinea pig in vitro stomach caused acetylcholine, intestinal and rabbit cause at body pipe smooth muscle and carbachol, has significant spasmolysis.The rabbit that the guinea pig in vitro intestinal cause histamine and physostigmine salicylate cause, in body intestinal tonic contraction, has significant inhibitory action.The Mouse Uterus tonic contraction that pituitrin causes can be resisted.To the hormesis of Cavia porcellus at body bladder and Rabbit thoracic aorta, mainly through excited adrenergic α receptor, and more weak than norepinephrine to aortal excitation.The energy perfusion flow that significantly Eff ect in Guinea Pigs lung causes because of histamine reduces, and can remove the spasm effect of histamine to bronchus chain.Also significantly can increase the bile flow of rat, and biliary tract tension force is increased.
Semen Litchi: sweet, puckery, temperature.Return liver, stomach warp.Essentials of Matea Medica: " enter Liver and kidney, loose stagnant gas, wards off cold-evil, control gastric abscess, married woman's vim and vigour pain." Compendium of Material Medica: " the loose stagnant gas of row, controls swelling of the scrotum pain due to disorder of QI, married woman's vim and vigour pain." cold-dispelling pain-relieving, promoting QI to circulate and dispersing the agglomeration of the pathogens.For colic of cold type pain due to disorder of QI, painful and swollen testis, heart peratodynia, hernia, the long-pending stomachache of the women's Qi stagnation stasis of blood.This thing is given the mouse subcutaneous injection (60-400mg/kg) of hungry 22 hours, blood glucose can be made to decline, and liver glycogen content also significantly reduces.
Rhizoma Cyperi: the pungent micro-hardship of nature and flavor is sweet, flat.Enter liver, tri-jiao channel.Compendium of Material Medica is said: " gas of Rhizoma Cyperi is flat and do not tremble with fear, fragrant and can alter, and how pungent its taste is can fall apart, and micro-hardship can be fallen, micro-sweet energy with "." Amplification on Materia Medica addendum ": " Rhizoma Cyperi, must soak with urine of baby boys, all vim and vigour medicines must with it, cause edema caused by disorder of QI and hemopoietic, the justice of this Yin grows while yang is generating is also." resolving depression of can regulating the flow of vital energy; Menstruction regulating and pain relieving; Antiabortive.Main distending pain over the hypochondrium; Mammary swelling is educated; Hernia pain; Menoxenia; Gastral cavity abdomen feeling of fullness pain; Belch acid regurgitation, vomiting and nausea; Abdominal pain during menstruation; Bleeding not during menses; Frequent fetal movement.For stagnation of QI due to depression of the liver, breast, the side of body, abdominal distention, dyspepsia, breast gastral cavity painful abdominal mass is vexed, and colic of cold type is suffered from abdominal pain, distending pain of the breast, menoxenia, amenorrhea dysmenorrhea.Ethanol extraction does not affect epinephrine and acetylcholine to the effect of blood pressure, but can the effect of part blocks histamine.5% Rhizoma Cyperi fluid extract is to the isolated uterine of the animals such as Cavia porcellus, rabbit, cat and dog, and no matter oneself pregnant or unpregnancy, has inhibitory action, makes that its contractility weakens, muscular tension reduces.
Fructus Citri Sarcodactylis: pungent, bitter, sour, temperature; Return liver, spleen, lung meridian." the southern regions of the Yunnan Province book on Chinese herbal medicine ": " Fructus Citri Sarcodactylis disappears cold syndrome of the stomach expectorant, controls gastric qi pain, the only cold pain in face, and middle circulation of qi promoting for tonifying liver warming the stomach, anti-nausea." " book on Chinese herbal medicine is new again ": " control gas soothing liver-QI, stomach function regulating reduces phlegm, and removing mass controls dysphagia and regurgitation, eliminating mass abdominal mass scrofula." liver-smoothing, qi-regulating, and stomach and alleviating pain.For stagnation of liver-QI and stomach-QI, distending pain in the chest and hypochondrium, gastral cavilty feeling of fullness, lack of appetite is vomitted.Limettin contained by this product shrinks guinea-pig isolated trachea caused by histamine, has antagonism; Show there is certain antiallergic activity in the isolated ileum segments in guinea pigs of Ovum Gallus domesticus album sensitization and isolated tracheal test.This product ethanol extract has obvious inhibitory action to rat, rabbits infestines, and intravenous administration also has same inhibitory action to anesthetized cat, rabbit at body intestinal tube.Fructus Citri Sarcodactylis ethanol extract significantly can increase the coronary flow of guinea pig isolated heart and improve the hypoxia-bearing capability of mice; Protective effect is had to the myocardial ischemia that rat causes because of pituitrin.
Fructus Citri: acrid in the mouth, sweet, nontoxic." explaining abstruseness of the canon of materia medica ": " gas of the reason part of the body cavity above the diaphragm housing the heart and lungs, preventing or arresting vomiting is inverse, feed, spleen invigorating." " book on Chinese herbal medicine is new again ": " suppressing the hyperactive liver Shu Yu, reason lung qi, stimulate the menstrual flow diuretic, controls waist beriberi." function depressed liver-energy dispersing and QI regulating, the chest stuffiness relieving reduces phlegm, dehumidifying and in.Cure mainly the therapeutic method to keep the adverse QI flowing downwards, except mind expectorant water.Boil wine to drink, control mental disorder cough.Decoct water, control pain due to disorder of QI under the heart.Root leaf is skin-deep same.These product are pungent can manage it loose, and the catharsis of bitter energy, enters Liver Channel and can unclog and readjust irritability and pain relieving.The strongly fragrant distending pain in the chest and hypochondrium for the treatment of the liver, gas perfume (or spice) is amusing, and pungent row hardship is let out, and enters taste with promoting the circulation of QI to alleviate the stagnation in middle-JIAO.With the abdominal distention controlling stagnation of QI in spleen and stomach, bitter dry the falling of these product is let out with preventing phlegm from forming and stopping coughing, and pungent row enters lung and the chest stuffiness relieving of regulating the flow of vital energy.With controlling abundant expectoration, cough, uncomfortable in chest etc.Hesperidin contained by these product to Cavia porcellus for want of vitamin C and cause eyes bulbar conjunctiva intravascular cells cohesion and capillary resistance reduce be improved effect, the cohesion of horse blood cell can be reduced.Hesperidin has prevention cold injury and suppresses the aldehyde reductase effect of rat lens.Obacunone has the effect strengthening isolated rabbit intestinal tension force and amplitude.
Flos Rosae Rugosae: warm in nature, sweet and slightly bitter taste, returns liver spleen channel.Supplementary Amplifications of the Compendium of Materia Medica: " and blood, promoting the circulation of blood, regulates the flow of vital energy.Control migratory arthralgia." " book on Chinese herbal medicine is new again ": " the strongly fragrant gas of soothing liver-QI gallbladder, spleen invigorating pathogenic fire reducing.Control cold type of pain in abdomen, gastral cavilty is long-pending cold, and holding concurrently can removing blood stasis." promoting the circulation of QI, promoting the circulation of blood, control migratory arthralgia, loose tired pain relieving.Flos Rosae Rugosae and Herb have convergence, can be used for woman in menstrual period too much, and leucorrhea with red and white discharge and enteritis, dysentery, the red half of intestinal are hemorrhage.To regulate the flow of vital energy resolving depression and blood dissipating blood stasis.Cure mainly stomachache due to hyperactive liver-QI attacking the stomach, new lingering pathogenic wind numbness, spitting of blood of spitting blood, menoxenia, leucorrhea with red and white discharge, dysentery, acute mastitis, toxic swelling.Containing 300 various chemical components in Flos Rosae Rugosae, as the alcohol of fragrance, aldehyde, fatty acid, phenol and containing the oil of essence and fat, to wake up stomach with easing the affected liver in normal food Flos Rosae Rugosae goods, have a respite and invigorate blood circulation, looks improving and the skin nourishing, make us refreshing refreshing.
FLOS MUME: sour and astringent, flat.Return liver, stomach, lung meridian.Supplementary Amplifications of the Compendium of Materia Medica: " " all sorts of flowers mirror ": powder for improving appetite is evil, and food of cooking congee, help the gas of sun clearly to rise, distillation point tea, promoting the production of body fluid to quench thirst, expelling summer-heat is washed tired." soothing liver-QI, stomach function regulating, reduces phlegm.Control globus hystericus, stomachache due to hyperactive liver-QI attacking the stomach, inappetence, dizzy, scrofula.Stomachache due to hyperactive liver-QI attacking the stomach.The circulation of qi promoting of this product fragrance enters liver stomach, and energy dispersing the stagnated live-QI to relieve the stagnation of QI, is amusing, regulating the flow of Qi and the middle Jiao.The distending pain over the hypochondrium for the treatment of stagnation of liver-QI and stomach-QI, gastral cavity abdomen feeling of fullness, belch is indigestion and loss of appetite, can with the compatibility such as Radix Bupleuri, Fructus Citri Sarcodactylis, Rhizoma Cyperi.Globus hystericus.The circulation of qi promoting of this product fragrance, dissipating phlegm and resolving masses.
Semen Aesculi: warm in nature, sweet in the mouth.Return liver, stomach warp.Regulating the flow of QI to ease the stomach, and stomach and alleviating pain., gastralgia vexed for breast abdominal distention.This product can dispersing the stagnated live-QI to relieve the stagnation of QI with row stagnant, again can regulating the flow of QI to ease the stomach with stomach function regulating.The card such as hypochondriac pain uncomfortable in chest, abdominal distention for the treatment of stagnation of liver-QI and stomach-QI, the normal and compatibility such as Fructus Akebiae, Fructus Citri Sarcodactylis; If control premenstrual distending pain of the breast, can be equal to Fructus Liquidambaris, Rhizoma Cyperi, Radix Curcumae and use.Aescin has protective effect to the cerebral edema that tin triethyl sulfate (Trietyistannous-sulfate) causes, the edema that leaf Saponin can suppress rat to cause due to heat injury.Semen Aesculi Total saponin through different dosing by way of all having the effect of anti-mouse acute decompression hypoxia.
Herba Aristolochiae: bitter, temperature; Enter liver,spleen,kidney warp." Bencao Tujing ": " Xie Fenglao.Herba Ephedrae then cures the wound cold diaphoresis, with Radix Et Rhizoma Rhei with taking gas." " book on Chinese herbal medicine is new again ": " removing heat from blood and promoting blood circulation, removes wind dampness removing, walks meridians, doublely controls the swollen pain of waist lower limb." circulation of qi promoting removing dampness, promoting blood circulation and stopping pain.Treat for stomachache, colicky, edema during pregnancy, puerperal, vim and vigour were suffered from abdominal pain, rheumatalgia.Promoting flow of QI and blood, pain relieving, diuresis.Edema during pregnancy, breast is suffered from abdominal pain, colic, rheumatalgia.Herba Aristolochiae, gas is invigorated blood circulation, and controls the medicine of all pains also.The gas of the person, suitable then peaceful, the inverse then vexed work of pain.As Young " side of directing at " Herba Aristolochiae controls the brachialgia of expectorant note, gas stays colic, and abdominal mass is gathered, and renal mass is suffered from abdominal pain, and puerperal, vim and vigour were suffered from abdominal pain, and he is as edema during pregnancy, edema over the face tachypnea, man's wind labor, and chronic cough is not healed, and knows and controls it with this medicine, peace of invariably getting into bed.Gai Weiqi is good at popular vim and vigour therefore also.See book discuss and cure mainly, only belong to the diseases such as pregnant edema during pregnancy, stomachache, wind consumptive disease, in his disease then not and here.Its reason controlled i.e., also only because bitter in the mouth master is in catharsis, warm in nature being led to lives, therefore passage of invigorating blood circulation, and makes water without unfavorable, and wind removes invariably, blood work invariably, and pain to be controlled therefore also all invariably with swollen.
Rhizoma Corydalis Decumbentis: bitter, micro-pungent, temperature.Return Liver Channel." national Chinese herbal medicine compilation ": " wind-damp dispelling, blood pressure lowering.Cure mainly rheumatic arthritis, lumbar muscle strain, hypertension, cerebrovas-cularaccident causes hemiplegia." function promoting blood circulation to remove obstruction in the collateral, promoting the circulation of QI to relieve pain.For apoplectic hemiplegia, injury from falling down, rheumatic arthritis, sciatica.Rhizoma Corydalis Decumbentis alkaloid can make anesthetized dog brain and lower extremity blood flow amount increase, and vascular resistance lowers (all there were significant differences through statistical procedures), and blood pressure slightly declines, and points out it to have the effect of expansion of cerebral vascular and lower limb vascular.1% summer is large to add in 15ml smooth muscle solution intestinal tube Rythmic contractions characteristic without injection 0.3ml and strengthens, and tension force strengthens, or even spasmodic contraction, points out and has excitation to rat isolated smooth muscle.For sciatica, rheumatic arthritis, fracture and sprain, poliomyelitis etc., have pain relieving, detumescence, alleviate ankylosis, promote suffering limb functional rehabilitation, the effects such as accelerating union of bone fracture.
Herba Leonuri: bitter in the mouth, pungent, cold nature, enters liver, pericardium channel, Tang Materia Medica: " apply fourth to swell, take juice and make fourth toxic swelling internal diabetes; Descend dead fetus in the uterus again, feeling of distension and oppression after main product; All assorted poison swell, and red trip etc. are swollen; Extracting juice such as bean drips in ear, main Ting ear; Middle a poisonous snake mentioned in ancient books snake venom, applies it." there is promoting blood flow to regulate menstruation, inducing diuresis to remove edema, the effect of heat-clearing and toxic substances removing, for the menoxenia caused by blood stasis, dysmenorrhea, amenorrhea, puerperal abdonimal pain or lochiorrhea, edema, dysuria, traumatic injury, the cards such as sore and toxic.Effective ingredient is Herba Leonuri element (Leonurin), take orally and can distend the blood vessels and make blood pressure drops, and have the adrenolytic effect of a word used in person's names, arteriosclerotic and neuropathic hypertension can be controlled, the frequency of uterus movement can be increased again, for puerperal promotes uterotonic, and cause effectively languisher to long-term metrorrhagia, leonurine solution has curariform action mask to frog neuromuscular specimen; There is diuresis to anesthetized rabbit intravenous injection, during high concentration, can haemolysis be caused. Herba Leonuri has remarkable therapeutic effect to the acute renal failure of Canis familiaris L. ischemic-type initial phase.
Herba Lycopi: bitter, pungent, tepor; Return liver, spleen channel.Effect blood circulation promoting and blood stasis dispelling, inducing diuresis to remove edema.Cure mainly blood stasis amenorrhea, stimulate the menstrual flow, lump in the abdomen, the stagnant stomachache of the stasis of blood in puerperal, body and face edema, injury from falling down, incised wound, sore and toxic, edema, ascites (edema of congestion retardance, the mutual resistance of the water stasis of blood is especially suitable).Containing volatile oil, glycoside, tannin and resin; Also containing flavonoid, phenols. aminoacid, organic acid, Saponin, various saccharides.
Caulis Spatholobi: nature and flavor are bitter, sweet, temperature.Return liver, kidney channel.Can relaxing muscles and tendons to promote blood circulation; Nourishing blood for regulating menstruation.Main numb hand and foot; Quadriplegia; Rheumatic arthralgia; Women has through uncomfortable; Dysmenorrhea; Amenorrhea.Function: enrich blood, invigorates blood circulation, dredging collateral.For menoxenia, blood deficiency and yellow complexion, paralysis and numbness, rheumatic arthralgia.This product is containing formoononetin, ononin, prunusetin., A Fuluomoxin, cajinin, licochalcone, isoliquiritigenin, tetrahydroxy chalcone derivative, Daidezin, 7-hydroxy-11,12-(methylenedioxy)coumestan, 9-O-methoxyl group coumestrol, 3,7-dihydroxy-6-melonia flavonol, epicatechin, protocatechuic acid, freidelin-3b-alcohol, b-sitosterol, daucosterol and 7-ketone group-b-sitosterol.Pharmacological action: to the effect of hemopoietic system; To the effect of blood coagulation, fibrinolytic; Suppress heart and the effect of reducing blood pressure; Antitumaous effect; To the adjustment of lipid metabolism.
Semen Vaccariae: bitter is flat; Return liver, stomach warp." book on Chinese herbal medicine newly organized ": " Semen Vaccariae, its property is very anxious, descending and do not go up passerby also.Inverse and the upper punch person of all diseases with can fall, therefore can rely on to make it use as minister also.But its property is overrun, should be for a long time unsuitable temporarily, can not know again yet.Or ask: Semen Vaccariae can stimulating milk secretion, be also can be up thing also.Not knowing that breast can not descend and purgation, is descending after all, but not also up.Upper Jiao has can descend person, all can descend logical, non-only row in the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels not all right in the part of the body cavity above the diaphragm housing the heart and lungs also." can promoting the circulation of blood regulating menstruation, reducing swelling and alleviating pain, lactogenesis of invigorating blood circulation, expedite the emergence of stimulating milk secretion, thymus dredging in puerperal.For blood stasis amenorrhea, dysmenorrhea, difficult labour; Lack of lactation after delivery, acute mastitis swells and ache; Pyretic stranguria, stranguria with blood, stranguria caused by urinary stone.Semen Vaccariae has antiearly pregnancy, Antiimplantation Action, also has regulation of physiological functions, affects the effect of internal metabolism.Also have report to think, Semen Vaccariae decoct has contraction to Isolated Rat Uterus; Its ethanol extract effect is especially strong.
Rhizoma et radix valerianae: pungent, sweet, warm; GUIXIN, Liver Channel." Traditional Chinese Medicine in Sichuan will ": " control cranial nerve and the heart, stomach is weak, the not normal and urine of chronic forms collapses." control irritability, stomach is weak, lumbago, menoxenia, traumatic injury.Apply its effect of calming the nerves and can be used for the treatment disease such as malaise, cardiopalmus dreaminess, can with the compatibility such as Semen Ziziphi Spinosae, Cortex Albiziae, Caulis Polygoni Multiflori; Another with Radix Salviae Miltiorrhizae, Herba Leonuri, Herba Lycopi, the same use of Flos Carthami, can be used to the disease for the treatment of abdominal pain in menstruation, soreness of the waist and knees, bone fracture and injury.Rhizoma et radix valerianae has quelling to act on to central nervous system, can stabilize nerve when excited, then can help to refresh when fatigue.Rhizoma et radix valerianae epoxy three ester contained by Rhizoma et radix valerianae root can help to alleviate spasm and pain, contributes to relaxing neuropathic dyspepsia, stomach spasm or enteritis.Total alkaloids in Rhizoma et radix valerianae has antibacterial action, especially can resist the infection that gram-positive bacterium is caused.The pink flowers Rhizoma et radix valerianae of Rhizoma et radix valerianae can relieving insomnia, sleep disorder, flurried, anxiety neurosis and other disorder, also can relax one's muscles simultaneously, make environment oil recover stable state.
Cortex Albiziae: sweet, flat; Enter the heart, Liver Channel." Japan hanako materia medica ": " soft extracts, subduing inflammation reuniting the fractured tendons and bones." Shennong's Herbal: " Herba Albiziae, sweet in the mouth is put down.Main settling five organs, sharp will, makes us happy carefree ... raw mountain valley." administration of antiallergic Cortex Albiziae decoct rat oral gavage can suppress its peritoneal mast cells retting conditions, in vitro tests also has similar effect.Cortex Albiziae decoct can obviously suppress antigen (horse serum) to the sensitization process of rat and antibody generation process.Cortex Albiziae is the bark of leguminous plant Herba Albiziae, Cortex Albiziae another name close confused skin, night platform skin, Herba Albiziae veneer, Cortex Albiziae has resolving depression of calming the nerves, the effect of eliminating carbuncle of invigorating blood circulation, Cortex Albiziae have treatment irritability, melancholy, sleeplessness, inside and outside carbuncle and ulcer, traumatic injury effect.
Radix Codonopsis: property is put down, sweet in the mouth, micro-acid; Return spleen, lung meridian.Invigorating the spleen and replenishing QI, spleen invigorating lung benefiting.For deficiency of the spleen and lung, cardiopalmus of breathing hard, anorexia and loose stool, dyspnea due to deficiency is coughed, and interior-heat is quenched one's thirst.These product are clinical conventional Qi-tonifying drug, function invigorating the spleen to benefit the lung, and effect person of modern times joins and is more weak, is applicable to various deficiency of vital energy deficiency person.Contained saponin, inulin, Alkaloid, starch etc. have strong effect in various degree to human body multi viscera, can improve the adaptability of human body.Have antiulcer, can increase intestinal tension force, regulate stomach motion, in the intestines and stomach coordinating preparation, reuse the intestines and stomach regulation of mental activities agent of Radix Codonopsis to chronic diarrhea, ulcerative colitis, antral gastritis, chronic atrophic gastritis etc. quite have effect.In addition, these product are the normal and eliminating evil medicine compatibility such as diaphoretic medicine, cathartic drug also, and the card that the dominations of pathogen such as deficiency of qi and blood are weakened body resistance for deficiency of vital energy diseases caused by exogenous pathogenic factor or interior-excess accumulation of heat, with strengthening vital QI to eliminate pathogenic factors, makes to attack heresy and healthy energy is not hindered.
The Radix Astragali: sweet, tepor; Return lung, spleen, liver, kidney channel.Essentials of Matea Medica: " Radix Astragali, life consolidating superficial resistance losslessly can be sent out, and have antiperspirant to stop; Process with invigorating middle warmer, beneficial vigour, strong taste.Hemopoietic, granulation promoting, evacuation of pus expelling the toxic substance from the body with tonic, carbuncle sore panacea.Variola does not rise, and yang deficiency should it without hot person." " book on Chinese herbal medicine justice ": " replenishing vital QI with drugs of warm nature taste, all middle gas is depressed, and spleen soil is weak, and the person of sinking is the most suitable for clearing heat in QI system for the Radix Astragali, soil in tonification.Its skin goes directly the skin table muscle of people, and solid protection defends sun, and enriching table point, is its speciality, so all diseases of exterior deficiency, and the most refreshing agent." function consolidating superficial resistance arresting sweating, inducing diuresis to remove edema, the evacuation of pus of holder skin ulcer, regulating fluid apssage.The Radix Astragali makes contractile ability strengthen, and can improve the blood circulation of whole body, can coronary artery dilator, Renal vascular and Rhizoma Bistortae peripheral vessel, make cutaneous circulation vigorous; The nonspecific immunity power of body can be improved, protect the liver and fall hypoglycemic effect, have inhibitory action to staphylococcus, blood dissolubility streptococcus, Diplococcus pneumoniae, dysentery bacterium etc.The Radix Astragali can appreciable impact splenocyte Information Conduction, realizes immunoregulation effect.Can be used for hypertension, ischemic heart desease, acute glomerulonephritis, gastric ulcer, psoriasis, diabetes, osteoporosis." Bencao Jingshu ": " the real table of function, person does not use pathogenic factor in the exterior; Can help gas, QI excess person does not use; Can interiorly fill in, tonifying for the deficiency, chest and diaphragm is gas-tight asks, the intestines and stomach has stagnant person not use; Energy YANG invigorating, overabundance of YANG leading to deficiency of YIN person avoids it; Part of the body cavity above the diaphragm housing the heart and lungs intenseness of heat, part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels deficiency and coldness person avoids it; The many anger of patient, disharmony in liver-QI person do not take; Variola blood system heat is notably forbidden.”
Rhizoma Dioscoreae: sweet in the mouth, property is put down, enter lung, spleen, kidney channel, there is strengthening the spleen and tonifying the lung, stomach reinforcing the kidney invigorating, benefit of reinforcing the kidney essence, hearing-improing and eyesight improving, help the five internal organs, bone and muscle strengthening, long will are calmed the nerves, effect of life lengthening, cure mainly that weakness of the spleen and stomach, lassitude, inappetence, chronic diarrhea and dysentery, insufficiency of lung-QI are dry, phlegm dyspnea cough, kidney qi loss, soreness of the waist and knees, lower limb flaccidity be weak, the red card such as swollen, fat of frequent micturition of quenching one's thirst, premature ejaculation of passing out semen, leukorrhagia nebulousurine, skin.Rhizoma Dioscoreae (parched with bran) spleen reinforcing stomach invigorating.For insufficiency of the spleen lack of appetite, loose stool of having loose bowels, leukorrhagia.This product yin nourishing can help wet, contain fullness in the epigastrium and abdomen so wet or have stagnant, person is unsuitable excess pathogen.Need to remind everybody, edible Rhizoma Dioscoreae generally without obvious contraindication, but has astriction because of it, thus catch a cold, constipation due to dry stool person and the intestines and stomach person of stagnating avoid use.
Radix Rhodiolae: sweet is bitter, flat; Return lung, heart channel.Radix Rhodiolae is the dry root welding technology of crassulaceae plants Radix Rhodiolae, and effect of Radix Rhodiolae and effect are can the kidney invigorating, regulate the flow of vital energy and nourish blood, and has promoting blood circulation and hemostasis, clearing away lung-heat to relieve cough, antipyretic, and the effect under leukorrhagia stopping, the side effect of Radix Rhodiolae does not temporarily find.Radix Rhodiolae energy improving water flood, blood-enriching and blood-promoting circulation, anti-cerebral anoxia, resisting fatigue, promoting blood circulation and hemostasis, clearing away lung-heat to relieve cough, change become silted up detumescence, antipyreticly to bring down a fever, nourish the effects such as vigour; Be used for the treatment of traumatic injury and burn and scald outward.Research points out that Oxidation is in a lot of advancing of disease process, plays very important role, such as cancer, cardiovascular diseases, diabetes, nerve degeneration and rheumatoid arthritis etc.In traditional medicine, Radix Rhodiolae is also for treating diabetes.Regarding assay utilizes mouse to make object, and test Radix Rhodiolae is movable to controlling the glycemic index of type-II diabetes, ferment and some antioxidative.
Fructus Hippophae: Fructus Hippophae and oil have very high medical value, can reduce cholesterol, and allevating angina pectoris shows effect, and prevents and treats the effect of coronary atherosclerotic heart disease in addition; Have and eliminate the phlegm, cough-relieving, relieving asthma and treat the effect of chronic tracheitis; Can gastric duodenal ulcer and dyspepsia etc. be treated, evident in efficacy to diseases such as chronic superficial gastritis, atrophic gastritis, colitis; Good therapeutical effect is had to burn, scald, cutter burning, cold injury; Good therapeutic effect is had to cervical erosion.Containing 7 kinds of Endospermum chinense Benth. materials such as isorhamnetin and glucoside, Quercetin, nimbecetin in sea buckthorn fruit, there is cough-relieving, the usefulness of eliminating the phlegm, expanding coronary vasodilator, reducing cholesterol of relievining asthma, be usually used in treating ischemic heart desease, 94% is reached to treatment angina pectoris effective percentage.In Fructus Hippophae, SOD active component enriches, and every gram of sea-buchthorn fresh fruit SOD content reaches 2746.0 enzyme units, and its content is 4 times of Radix Ginseng.It can block the free radical because substance in vivo peroxidating produces, and the generation of this free radical and human senility, disease is closely related.
Herba Micromeriae Biflorae: pungent, temperature.Function cures mainly: expelling pathogenic wind from the body surface, and warming middle-JIAO dehumidifies.For cold cough, stomachache, acute gastroenteritis, dyspepsia, abdominal distention, stomachache, colicky, prevention dysentery.
Bulbus Lilii: Bulbus Lilii is except containing protein 21.29%, fat 12.43%, reducing sugar 11.47%, starch 1.61%, and calcium, phosphorus, ferrum, every hectogram is containing outside the nutrients such as 1.443 milligrams of vitamin Bs, 21.2 milligrams of vitamin Cs, also containing some special nutritional labelings, as multiple alkaloids such as colchicine.These composition comprehensive functions, in human body, not only have the merit of good nutritious tonifying, but also to dry in autumn and multiple Seasonal diseases that is that cause has certain preventive and therapeutic effect.The traditional Chinese medical science is said fresh Bulbus Lilii has tranquilizing by nourishing the heart, effect of nourishing the lung to arrest cough, weakling is after being ill highly profitable.
Radix Ophiopogonis: sweet, the micro-hardship of property, is slightly cold; GUIXIN, lung, stomach warp.Have YIN nourishing and the production of body fluid promoting, effect that lung moistening clears away heart-fire, can be used for sore throat pharyngalgia, Tianjin wound is thirsty, and interior-heat is quenched one's thirst, vexed insomnia, dryness of the intestine constipation etc.Clear the moon of supporting lung stomach goes heart use more, and YIN nourishing clears away heart-fire the use that connects with the heart more.These product are sweet cold clear and rich, and be apt to control deficiency of stomach-Yin, dry tongue is thirsty, indigestion and loss of appetite not hungry card such as grade.In addition, also availablely deficiency of YIN dryness of the intestine is controlled, constipation person.Modern study shows, can improve immunologic function Radix Ophiopogonis, various bacteria be had to inhibitory action, can strengthen pituitary adrenal system function, improve organism adaptation ability.Radix Ophiopogonis joins Radix Adenophorae (Radix Glehniae), and lung stomach is ruled together, and has the cool stomach of lung heat clearing, the good effectiveness of YIN nourishing and the production of body fluid promoting, for the few expectorant of the dry cough caused by lung-dryness syndrome due to deficiency of YIN or thermal burn lung yin, and the diseases such as dry laryngopharynx.Medication is noted: all Deficiency and coldness of spleen and stomach are had loose bowels, and stomach has phlegm retention turbid damp and sudden and violent sense cough due to wind and cold person all to avoid to take Radix Ophiopogonis.
Oxyria sinensis Hemsl.: light is cool.Function cures mainly: moistening the lung and resolving phlegm.Cure mainly pulmonary tuberculosis, cough due to lung-heat.
Rhizoma alpiniae pumilae: pungent, temperature.Function cures mainly: relieving cough and asthma, dispersing cold for relieving pain, except rheumatism, separates sore.For wind and cold cough with asthma, peratodynia, Fengshi Guanjie pain, falls and damages blood stasis stagnation, menoxenia, innominate toxic swelling.
Volume stem knotweed: pungent; Warm in nature.Function cures mainly: strengthening the spleen to promote digestion.Main dyspepsia; Diarrhoea.
Radix Oryzae Glutinosae: sweet is flat.Function cures mainly: yin nourishing, hidroschesis, stomach invigorating.For spontaneous perspiration, night sweat, hepatitis.
Folium Fumicis Dentati: bitter; Cold in nature.There is heat-clearing and toxic substances removing; Effect of killing parasites for relieving itching, cures mainly acute mastitis; Sore swollen toxin; Scabies.
Herba Hemisteptae Lyratae: pungent, flat.Function cures mainly: dispersing swelling and dissipating binds, heat-clearing and toxic substances removing.For mastitis, cervical lymphadenitis, carbuncle furuncle, rubella pruritus.
In described medicine, the parts by weight of each raw medicinal material are preferably: Pericarpium Citri Reticulatae Viride 10-20 weight portion, Semen Litchi 10-20 weight portion, Rhizoma Cyperi 15-25 weight portion, Fructus Citri Sarcodactylis 10-20 weight portion, Fructus Citri 10-20 weight portion, Flos Rosae Rugosae 10-20 weight portion, FLOS MUME 10-20 weight portion, Semen Aesculi 15-25 weight portion, Herba Aristolochiae 10-20 weight portion, Rhizoma Corydalis Decumbentis 10-15 weight portion, Herba Leonuri 15-25 weight portion, Herba Lycopi 15-25 weight portion, Caulis Spatholobi 10-20 weight portion, Semen Vaccariae 5-15 weight portion, Rhizoma et radix valerianae 10-20 weight portion, Cortex Albiziae 10-20 weight portion, Radix Codonopsis 10-20 weight portion, Radix Astragali 15-25 weight portion, Rhizoma Dioscoreae 15-25 weight portion, Radix Rhodiolae 5-10 weight portion, Fructus Hippophae 10-20 weight portion, Herba Micromeriae Biflorae 10-20 weight portion, Bulbus Lilii 15-25 weight portion, Radix Ophiopogonis 10-20 weight portion and Oxyria sinensis Hemsl. 10-20 weight portion.
In described medicine, the parts by weight of each raw medicinal material also can be preferably: Pericarpium Citri Reticulatae Viride 15 weight portion, Semen Litchi 16 weight portion, Rhizoma Cyperi 21 weight portion, Fructus Citri Sarcodactylis 15 weight portion, Fructus Citri 15 weight portion, Flos Rosae Rugosae 15 weight portion, FLOS MUME 13 weight portion, Semen Aesculi 17 weight portion, Herba Aristolochiae 14 weight portion, Rhizoma Corydalis Decumbentis 12 weight portion, Herba Leonuri 20 weight portion, Herba Lycopi 19 weight portion, Caulis Spatholobi 15 weight portion, Semen Vaccariae 8 weight portion, Rhizoma et radix valerianae 15 weight portion, Cortex Albiziae 12 weight portion, Radix Codonopsis 16 weight portion, the Radix Astragali 20 weight portion, Rhizoma Dioscoreae 20 weight portion, Radix Rhodiolae 7 weight portion, Fructus Hippophae 15 weight portion, Herba Micromeriae Biflorae 15 weight portion, Bulbus Lilii 21 weight portion, Radix Ophiopogonis 15 weight portion and Oxyria sinensis Hemsl. 15 weight portion.
In described medicine, the parts by weight of each raw medicinal material can be preferably again: Pericarpium Citri Reticulatae Viride 10-20 weight portion, Semen Litchi 10-20 weight portion, Rhizoma Cyperi 15-25 weight portion, Fructus Citri Sarcodactylis 10-20 weight portion, Fructus Citri 10-20 weight portion, Flos Rosae Rugosae 10-20 weight portion, FLOS MUME 10-20 weight portion, Semen Aesculi 15-25 weight portion, Herba Aristolochiae 10-20 weight portion, Rhizoma Corydalis Decumbentis 10-15 weight portion, Herba Leonuri 15-25 weight portion, Herba Lycopi 15-25 weight portion, Caulis Spatholobi 10-20 weight portion, Semen Vaccariae 5-15 weight portion, Rhizoma et radix valerianae 10-20 weight portion, Cortex Albiziae 10-20 weight portion, Radix Codonopsis 10-20 weight portion, Radix Astragali 15-25 weight portion, Rhizoma Dioscoreae 15-25 weight portion, Radix Rhodiolae 5-10 weight portion, Fructus Hippophae 10-20 weight portion, Herba Micromeriae Biflorae 10-20 weight portion, Bulbus Lilii 15-25 weight portion, Radix Ophiopogonis 10-20 weight portion, Oxyria sinensis Hemsl. 10-20 weight portion, Rhizoma alpiniae pumilae 10-20 weight portion, volume stem knotweed 15-25 weight portion, Radix Oryzae Glutinosae 10-20 weight portion, Folium Fumicis Dentati 10-20 weight portion and Herba Hemisteptae Lyratae 15-25 weight portion.
In described medicine, the parts by weight of each raw medicinal material can also be preferably: Pericarpium Citri Reticulatae Viride 15 weight portion, Semen Litchi 16 weight portion, Rhizoma Cyperi 21 weight portion, Fructus Citri Sarcodactylis 15 weight portion, Fructus Citri 15 weight portion, Flos Rosae Rugosae 15 weight portion, FLOS MUME 13 weight portion, Semen Aesculi 17 weight portion, Herba Aristolochiae 14 weight portion, Rhizoma Corydalis Decumbentis 12 weight portion, Herba Leonuri 20 weight portion, Herba Lycopi 19 weight portion, Caulis Spatholobi 15 weight portion, Semen Vaccariae 8 weight portion, Rhizoma et radix valerianae 15 weight portion, Cortex Albiziae 12 weight portion, Radix Codonopsis 16 weight portion, the Radix Astragali 20 weight portion, Rhizoma Dioscoreae 20 weight portion, Radix Rhodiolae 7 weight portion, Fructus Hippophae 15 weight portion, Herba Micromeriae Biflorae 15 weight portion, Bulbus Lilii 21 weight portion, Radix Ophiopogonis 15 weight portion, Oxyria sinensis Hemsl. 15 weight portion, Rhizoma alpiniae pumilae 15 weight portion, volume stem knotweed 21 weight portion, Radix Oryzae Glutinosae 15 weight portion, Folium Fumicis Dentati 15 weight portion and Herba Hemisteptae Lyratae 19 weight portion.
When the dosage form of medicine is tablet, described preparation method comprises the following steps:
The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 4 ~ 5 times is the ethanol of 85% ~ 90%, reflux 2 ~ 4 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 90% ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 2 ~ 3 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 2 ~ 3 hours, pulverize, sieve, obtain 300 order ~ 400 object micropowders;
3rd step, by the micropowders that second step obtains, add relative to the microcrystalline Cellulose of its quality 0.1 ~ 0.3 times, 0.15 ~ 0.3 times of lactose, the starch of 0.2 ~ 0.35 times, sieve, mix homogeneously, granulate, drying, adds relative to micropowders quality 0.025 ~ 0.04 times of magnesium stearate, granulate, tabletting, makes.
When the dosage form of medicine is injection, described preparation method comprises the following steps:
The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 0.1 ~ 10 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 95%;
Second step, adding relative to the determining alcohol of the quality 3 ~ 5 times of described mixed powder in the mixed powder that the first step obtains is the ethanol of 85% ~ 95%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 24 ~ 36 hours under the condition of 5 DEG C ~ 10 DEG C, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, concentrated and dry, and put into super micron mill pulverizing 40 ~ 60 minutes at this, the micron particles of acquisition 0.1 ~ 10 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,
3rd step, gets mixed powder 10g ~ 20g that second step obtains, adds propylene glycol 30g ~ 50g, add 200ml water for injection, stirs and makes it dissolve, inject water to 1000ml further, then add 1g ~ 1.5g needle-use activated carbon, fully stir 30 ~ 50 minutes; Decarbonization filtering; With 0.22 ~ 0.24 μm of filtering with microporous membrane; Lyophilization obtains sterilized powder, subpackage embedding.
When the dosage form of medicine is liniment, described preparation method comprises the following steps:
Step one: first described raw medicinal material is ground into coarse powder, then pulverizes further, cross 100 mesh sieves, the enable fine powder amount by 100 mesh sieves at least reaches 40%, collects and obtains fine powder a by the fine powder of 100 mesh sieves;
Step 2: the coarse powder not by 100 mesh sieves is dropped into multi-function extractor and extracts twice, first time adds weight portion 8-10 times amount soak by water 1-3 hour, and second time adds weight portion 6-10 times amount soak by water 1-3 hour, merges twice decocting liquid, filters to get filtrate; The heating of gained filtrate is concentrated into pasty state, and after putting into the oven dry of 80 DEG C, baking oven, room temperature cools, and grinds to form fine powder b;
Step 3: call in glycerol after being mixed with fine powder b by fine powder a and make liniment.
Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.
Embodiment 1 tablet
Embodiments provide a kind of medicine being used for the treatment of caused by hepatic stagnation qi stagnation hypogalactia in puerperal, the parts by weight of its each raw medicinal material are: Pericarpium Citri Reticulatae Viride 15 weight portion, Semen Litchi 16 weight portion, Rhizoma Cyperi 21 weight portion, Fructus Citri Sarcodactylis 15 weight portion, Fructus Citri 15 weight portion, Flos Rosae Rugosae 15 weight portion, FLOS MUME 13 weight portion, Semen Aesculi 17 weight portion, Herba Aristolochiae 14 weight portion, Rhizoma Corydalis Decumbentis 12 weight portion, Herba Leonuri 20 weight portion, Herba Lycopi 19 weight portion, Caulis Spatholobi 15 weight portion, Semen Vaccariae 8 weight portion, Rhizoma et radix valerianae 15 weight portion, Cortex Albiziae 12 weight portion, Radix Codonopsis 16 weight portion, the Radix Astragali 20 weight portion, Rhizoma Dioscoreae 20 weight portion, Radix Rhodiolae 7 weight portion, Fructus Hippophae 15 weight portion, Herba Micromeriae Biflorae 15 weight portion, Bulbus Lilii 21 weight portion, Radix Ophiopogonis 15 weight portion and Oxyria sinensis Hemsl. 15 weight portion.
Its preparation method comprises the following steps:
The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 4 times is the ethanol of 85%, reflux 3 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 90% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 2 times again, reflux 2 hours, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 2.5 hours, pulverize, sieve, obtain 350 object micropowders;
3rd step, by the micropowders that second step obtains, adds relative to the microcrystalline Cellulose of its quality 0.2 times, 0.2 times of lactose, the starch of 0.25 times, sieves, mix homogeneously, granulates, dry, adds relative to micropowders quality 0.03 times of magnesium stearate, granulate, tabletting, makes.
Embodiment 2 injection
Embodiments provide a kind of medicine being used for the treatment of caused by hepatic stagnation qi stagnation hypogalactia in puerperal, the parts by weight of its each raw medicinal material are: Pericarpium Citri Reticulatae Viride 15 weight portion, Semen Litchi 16 weight portion, Rhizoma Cyperi 21 weight portion, Fructus Citri Sarcodactylis 15 weight portion, Fructus Citri 15 weight portion, Flos Rosae Rugosae 15 weight portion, FLOS MUME 13 weight portion, Semen Aesculi 17 weight portion, Herba Aristolochiae 14 weight portion, Rhizoma Corydalis Decumbentis 12 weight portion, Herba Leonuri 20 weight portion, Herba Lycopi 19 weight portion, Caulis Spatholobi 15 weight portion, Semen Vaccariae 8 weight portion, Rhizoma et radix valerianae 15 weight portion, Cortex Albiziae 12 weight portion, Radix Codonopsis 16 weight portion, the Radix Astragali 20 weight portion, Rhizoma Dioscoreae 20 weight portion, Radix Rhodiolae 7 weight portion, Fructus Hippophae 15 weight portion, Herba Micromeriae Biflorae 15 weight portion, Bulbus Lilii 21 weight portion, Radix Ophiopogonis 15 weight portion, Oxyria sinensis Hemsl. 15 weight portion, Rhizoma alpiniae pumilae 15 weight portion, volume stem knotweed 21 weight portion, Radix Oryzae Glutinosae 15 weight portion, Folium Fumicis Dentati 15 weight portion and Herba Hemisteptae Lyratae 19 weight portion.
Its preparation method comprises the following steps:
The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 0.1 ~ 10 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 95%;
Second step, adding relative to the determining alcohol of the quality 4 times of described mixed powder in the mixed powder that the first step obtains is the ethanol of 90%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 30 hours under the condition of 8 DEG C, adopt percolation with the speed of 1ml per minute slowly percolation, collect percolate, concentrated and dry, and put into super micron mill pulverizing 50 minutes at this, the micron particles of acquisition 0.1 ~ 10 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,
3rd step, gets the mixed powder 15g that second step obtains, adds propylene glycol 40g, add 200ml water for injection, stirs and makes it dissolve, inject water to 1000ml further, then add 1g needle-use activated carbon, fully stirs 40 minutes; Decarbonization filtering; With 0.23 μm of filtering with microporous membrane; Lyophilization obtains sterilized powder, subpackage embedding.
Embodiment 3 liniment
Embodiments provide a kind of medicine being used for the treatment of caused by hepatic stagnation qi stagnation hypogalactia in puerperal, the parts by weight of its each raw medicinal material are: Pericarpium Citri Reticulatae Viride 10-20 weight portion, Semen Litchi 10-20 weight portion, Rhizoma Cyperi 15-25 weight portion, Fructus Citri Sarcodactylis 10-20 weight portion, Fructus Citri 10-20 weight portion, Flos Rosae Rugosae 10-20 weight portion, FLOS MUME 10-20 weight portion, Semen Aesculi 15-25 weight portion, Herba Aristolochiae 10-20 weight portion, Rhizoma Corydalis Decumbentis 10-15 weight portion, Herba Leonuri 15-25 weight portion, Herba Lycopi 15-25 weight portion, Caulis Spatholobi 10-20 weight portion, Semen Vaccariae 5-15 weight portion, Rhizoma et radix valerianae 10-20 weight portion, Cortex Albiziae 10-20 weight portion, Radix Codonopsis 10-20 weight portion, Radix Astragali 15-25 weight portion, Rhizoma Dioscoreae 15-25 weight portion, Radix Rhodiolae 5-10 weight portion, Fructus Hippophae 10-20 weight portion, Herba Micromeriae Biflorae 10-20 weight portion, Bulbus Lilii 15-25 weight portion, Radix Ophiopogonis 10-20 weight portion and Oxyria sinensis Hemsl. 10-20 weight portion.
Its preparation method comprises the following steps:
Step one: first described raw medicinal material is ground into coarse powder, then pulverizes further, cross 100 mesh sieves, the enable fine powder amount by 100 mesh sieves at least reaches 40%, collects and obtains fine powder a by the fine powder of 100 mesh sieves;
Step 2: the coarse powder not by 100 mesh sieves is dropped into multi-function extractor and extracts twice, first time adds weight portion 9 times amount soak by water 2 hours, and second time adds weight portion 7 times amount soak by water 2 hours, merges twice decocting liquid, filters to get filtrate; The heating of gained filtrate is concentrated into pasty state, and after putting into the oven dry of 80 DEG C, baking oven, room temperature cools, and grinds to form fine powder b;
Step 3: call in glycerol after being mixed with fine powder b by fine powder a and make liniment.
Toxicity test
1, animal selects cleaning grade kunming mice 40, male and female half and half, body weight 18 ~ 22g; Laboratory observation 1 week, before each administration, fasting 4h, can't help water.By above cleaning grade kunming mice laboratory observation 1 week, the cleaning grade kunming mice of clinical observation result health is divided into two groups at random, often organizes 20 (male and female half and half).Wherein one group is set as experimental group, and another group is set as matched group.Mouse tail vein injection, experimental group, with successive administration in maximum (former) concentration of the injection of the embodiment of the present invention 2 and maximum volume 24h 3 times, gives 0.6ml/20g(Mouse Weight) medicine, matched group is to the injection normal saline of same volume.Weigh the weight of animals before administration and observe feed intake and drinking-water situation; After administration, every day weighs the weight of animals, feed intake and undue toxicity's symptom at same time, Continuous Observation 14d.By the observation of 14d, do not have undue toxicity to react appearance, do not occur yet animal dead phenomenon, body weight change does not have notable difference (P > 0.05), illustrates that this injection does not have a significant effect to experiment mice body weight.
2, apply NIH mice 40, SPF level, male and female half and half, body weight 18 ~ 22g, carries out acute toxicity test.Mice is divided into two groups at random, often organizes 20, i.e. matched group and administration group, fasting 12 hours before experiment; The tablet dissolved prepared by embodiments of the invention 1 is in water, (concentration is 6.58g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg(and unit dosage form is 32.9 crude drugs/kg), matched group gives normal saline, administration in a day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Mouse oral gavage tablet LD50>32.9 crude drug/kg of the present invention, every day, maximum dosage-feeding was 65.8 crude drugs/kg/ day.Chinese medicine clinical application amount of the present invention be 4.4g crude drug/day/people, adult body weight in 60KG, average dosage is 0.073g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight is in 20g) oral administration gavage Chinese medicine of the present invention is 901 times of quantity.Therefore tablet acute toxicity of the present invention is low, clinical drug safety.
3, the tablet that contains of the embodiment of the present invention 1 is pressed 7.81,18.34 and 40.11g crude drug/kg continuous use 12 weeks (1.0ml/100g body weight to mice, every day 2 times) and drug withdrawal after 4 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of Chinese medicine preparation of the present invention to mice all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 12 weeks and drug withdrawal are after 4 weeks, and Organs of Mice is all without obviously changing.Illustrate that Chinese medicine preparation of the present invention is little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.
4, SD rat 20, male and female half and half, body weight 90g ~ 180g, the liniment embodiment of the present invention 3 obtained percutaneous smears 5000mg/kg body weight dose, observe 15 days, do not find obvious poisoning symptom, without dead, animal gross anatomy no abnormality seen, judges that these product are to the nontoxic level in the true border of rat acute percutaneous toxicity.
5, get healthy albino guinea-pig 18, body weight 250-300g, male and female dual-purpose, reject both sides dorsal body setae before test, every side 3 × 3cm, is divided into test group, blank group (substrate) and positive controls at random.Positive controls DNFB, sensitization 1% concentration, excites and uses 0.1% concentration.The liniment 0.1g getting the embodiment of the present invention 3 is applied to unhairing district, back, the next day 1 time, totally 3 times.In latter 14 days of last contact, at back, the same area smeared this product 0.1g, at once observes after removing medicine after 6h, and in 24,48,72h observes with or without anaphylaxis.Blank group and positive controls excite by same method and contact and observe.Result of the test: namely positive controls animal skin occurs localized erythema and slight edema in sensitization after 1 hour, within 24 hours, symptoms of allergic increases the weight of, and have scleroma to be formed, sensitization rate is 100%, all there is not any symptoms of allergic in test group and blank treated animal skin, sensitization rate is 0%.
Clinical trial
Case selection: fetch come from obstetrics of the court puerpera 150 example puerperal caused by hepatic stagnation qi stagnation hypogalactia patient, age 29-41 year, cesarean 86 example, spontaneous labor 64 example, 3 days-1 month puerperal milk very less or completely without, have following symptom in various degree: milk is dense thick, or agalactia, the hard pain of mammary swelling, depressed emotion, breast side of body feeling of distension and oppression, inappetence, or slight fever, body of the tongue is normal, yellow and thin fur, stringy and thready pulse or stringy and rapid pulse.150 routine patients are divided into three groups at random, often organize 50 examples.
Therapeutic Method:
Embodiment group 1: the tablet taking the embodiment of the present invention 1, every day twice, each three, takes 3-7 days continuously;
Embodiment group 2: the injection using the embodiment of the present invention 2, once a day, each 50mg/kg, every day is no more than 4g, uses 3-7 continuously;
Matched group: take Os Sus domestica Fructus Lycopersici esculenti medicated porridge, every day twice, uses 3-7 days continuously.
Criterion of therapeutical effect: recovery from illness: galactopoiesis is normal, the normal suckling of energy; Effective: galactopoiesis increases, or galactopoiesis is normal, but the few nursing not of amount; Invalid: galactopoiesis is without change; Wherein, effective percentage is the percentage ratio that recovery from illness number and significant figure sum account for sum.
Therapeutic outcome:
See table 1 and table 2, as can be seen from Table 1, adopt Drug therapy caused by hepatic stagnation qi stagnation in puerperal hypogalactia of the present invention, relative to traditional Dietotherapy method in curative effect, there is significant improvement; As can be seen from Table 2, adopt Drug therapy caused by hepatic stagnation qi stagnation in puerperal hypogalactia of the present invention, relative to traditional Dietotherapy method, treatment the course for the treatment of on significantly shorten.
The each experimental group of table 1 treats Clinical efficacy comparison example after 3-7 days respectively
Group Number of cases Cure Effectively Invalid Effective percentage 12-->
Embodiment group 1 50 27 20 3 94%
Embodiment group 2 50 29 19 2 96%
Matched group 50 17 19 14 72%
Cure after each experimental group of table 2 treats 3-7 days respectively and efficiently individual quantity and time comparative example (%)
Group Number of cases 1-3 days 3-5 days 6-7 days
Embodiment group 1 47 4（8.5%） 25（53.2%） 18（38.3%）
Embodiment group 2 48 6（12.5%） 26（54.2%） 16（33.3%）
Matched group 36 2（5.6%） 9（25.0%） 25（69.4%）
According to the clinical statistics in above table, medicine provided by the invention have rapid-action, effective percentage is high, determined curative effect, safety are high, the advantage that has no side effect.
Model case 1: grandson, 27 years old, spontaneous labor, body constitution is relatively become thin, 3 days puerperal agalactia, the hard pain of mammary swelling, depressed emotion, breast the side of body feeling of distension and oppression, inappetence, yellow and thin fur, stringy and thready pulse.Through inquiry household, grandson's goodwill as between spouses is got along well, antenatal quarrel.Disease belongs to caused by hepatic stagnation qi stagnation hypogalactia in puerperal.Use the injection of the embodiment of the present invention 2 to carry out treating and with the use of the liniment of the embodiment of the present invention 3, injection once a day, each 50mg/kg, every day is no more than 4g, and every day smeared breast three times by liniment, use continuously 2 days effective afterwards, continual cure 2 days, recovery from illness, follows up a case by regular visits to and does not recur half a year.
Model case 2: Liu, 34 years old, cesarean, breast was few, because worrying that hypogalactia affects child and grows, with anxiety.The hard pain of mammary swelling, depressed emotion, breast side of body feeling of distension and oppression, slight fever, body of the tongue is normal, yellow and thin fur, wiry and frequent pulse.Disease belongs to caused by hepatic stagnation qi stagnation hypogalactia in puerperal.Use the tablet of the embodiment of the present invention 1 to treat, every day twice, each three, take 4 days continuously effectively, continue to take recovery from illness in 2 days, galactopoiesis is normal, and the normal suckling of energy, follows up a case by regular visits to and do not recur half a year.
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.

Claims (6)

1. be used for the treatment of the medicine of caused by hepatic stagnation qi stagnation hypogalactia in puerperal, it is characterized in that, described medicine comprises following raw medicinal material: Pericarpium Citri Reticulatae Viride, Semen Litchi, Rhizoma Cyperi, Fructus Citri Sarcodactylis, Fructus Citri, Flos Rosae Rugosae, FLOS MUME, Semen Aesculi, Herba Aristolochiae, Rhizoma Corydalis Decumbentis, Herba Leonuri, Herba Lycopi, Caulis Spatholobi, Semen Vaccariae, Rhizoma et radix valerianae, Cortex Albiziae, Radix Codonopsis, the Radix Astragali, Rhizoma Dioscoreae, Radix Rhodiolae, Fructus Hippophae, Herba Micromeriae Biflorae, Bulbus Lilii, Radix Ophiopogonis, Oxyria sinensis Hemsl., Rhizoma alpiniae pumilae, volume stem knotweed, Radix Oryzae Glutinosae, Folium Fumicis Dentati and Herba Hemisteptae Lyratae.
2. the medicine being used for the treatment of caused by hepatic stagnation qi stagnation hypogalactia in puerperal according to claim 1, is characterized in that, in described medicine, the parts by weight of each raw medicinal material are: Pericarpium Citri Reticulatae Viride 10-20 weight portion, Semen Litchi 10-20 weight portion, Rhizoma Cyperi 15-25 weight portion, Fructus Citri Sarcodactylis 10-20 weight portion, Fructus Citri 10-20 weight portion, Flos Rosae Rugosae 10-20 weight portion, FLOS MUME 10-20 weight portion, Semen Aesculi 15-25 weight portion, Herba Aristolochiae 10-20 weight portion, Rhizoma Corydalis Decumbentis 10-15 weight portion, Herba Leonuri 15-25 weight portion, Herba Lycopi 15-25 weight portion, Caulis Spatholobi 10-20 weight portion, Semen Vaccariae 5-15 weight portion, Rhizoma et radix valerianae 10-20 weight portion, Cortex Albiziae 10-20 weight portion, Radix Codonopsis 10-20 weight portion, Radix Astragali 15-25 weight portion, Rhizoma Dioscoreae 15-25 weight portion, Radix Rhodiolae 5-10 weight portion, Fructus Hippophae 10-20 weight portion, Herba Micromeriae Biflorae 10-20 weight portion, Bulbus Lilii 15-25 weight portion, Radix Ophiopogonis 10-20 weight portion, Oxyria sinensis Hemsl. 10-20 weight portion, Rhizoma alpiniae pumilae 10-20 weight portion, volume stem knotweed 15-25 weight portion, Radix Oryzae Glutinosae 10-20 weight portion, Folium Fumicis Dentati 10-20 weight portion and Herba Hemisteptae Lyratae 15-25 weight portion.
3. the medicine being used for the treatment of caused by hepatic stagnation qi stagnation hypogalactia in puerperal according to claim 1 and 2, it is characterized in that, in described medicine, the parts by weight of each raw medicinal material are: Pericarpium Citri Reticulatae Viride 15 weight portion, Semen Litchi 16 weight portion, Rhizoma Cyperi 21 weight portion, Fructus Citri Sarcodactylis 15 weight portion, Fructus Citri 15 weight portion, Flos Rosae Rugosae 15 weight portion, FLOS MUME 13 weight portion, Semen Aesculi 17 weight portion, Herba Aristolochiae 14 weight portion, Rhizoma Corydalis Decumbentis 12 weight portion, Herba Leonuri 20 weight portion, Herba Lycopi 19 weight portion, Caulis Spatholobi 15 weight portion, Semen Vaccariae 8 weight portion, Rhizoma et radix valerianae 15 weight portion, Cortex Albiziae 12 weight portion, Radix Codonopsis 16 weight portion, the Radix Astragali 20 weight portion, Rhizoma Dioscoreae 20 weight portion, Radix Rhodiolae 7 weight portion, Fructus Hippophae 15 weight portion, Herba Micromeriae Biflorae 15 weight portion, Bulbus Lilii 21 weight portion, Radix Ophiopogonis 15 weight portion, Oxyria sinensis Hemsl. 15 weight portion, Rhizoma alpiniae pumilae 15 weight portion, volume stem knotweed 21 weight portion, Radix Oryzae Glutinosae 15 weight portion, Folium Fumicis Dentati 15 weight portion and Herba Hemisteptae Lyratae 19 weight portion.
4. the preparation method being used for the treatment of the medicine of caused by hepatic stagnation qi stagnation hypogalactia in puerperal according to any one of claim 1-3, is characterized in that, the dosage form of described medicine is tablet, and described preparation method comprises the following steps:
The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 4 ~ 5 times is the ethanol of 85% ~ 90%, reflux 2 ~ 4 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 90% ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 2 ~ 3 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 2 ~ 3 hours, pulverize, sieve, obtain 300 order ~ 400 object micropowders;
3rd step, by the micropowders that second step obtains, add relative to the microcrystalline Cellulose of its quality 0.1 ~ 0.3 times, 0.15 ~ 0.3 times of lactose, the starch of 0.2 ~ 0.35 times, sieve, mix homogeneously, granulate, drying, adds relative to micropowders quality 0.025 ~ 0.04 times of magnesium stearate, granulate, tabletting, makes.
5. the preparation method of medicine for caused by hepatic stagnation qi stagnation hypogalactia in puerperal according to any one of claim 1-4, it is characterized in that, the dosage form of described medicine is injection, and described preparation method comprises the following steps:
The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 0.1 ~ 10 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 95%;
Second step, adding relative to the determining alcohol of the quality 3 ~ 5 times of described mixed powder in the mixed powder that the first step obtains is the ethanol of 85% ~ 95%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 24 ~ 36 hours under the condition of 5 DEG C ~ 10 DEG C, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, concentrated and dry, and put into super micron mill pulverizing 40 ~ 60 minutes at this, the micron particles of acquisition 0.1 ~ 10 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,
3rd step, gets mixed powder 10g ~ 20g that second step obtains, adds propylene glycol 30g ~ 50g, add 200ml water for injection, stirs and makes it dissolve, inject water to 1000ml further, then add 1g ~ 1.5g needle-use activated carbon, fully stir 30 ~ 50 minutes; Decarbonization filtering; With 0.22 ~ 0.24 μm of filtering with microporous membrane; Lyophilization obtains sterilized powder, subpackage embedding.
6. the preparation method of medicine for caused by hepatic stagnation qi stagnation hypogalactia in puerperal according to any one of claim 1-5, it is characterized in that, the dosage form of described medicine is liniment, and described preparation method comprises the following steps:
Step one: first described raw medicinal material is ground into coarse powder, then pulverizes further, cross 100 mesh sieves, the enable fine powder amount by 100 mesh sieves at least reaches 40%, collects and obtains fine powder a by the fine powder of 100 mesh sieves;
Step 2: the coarse powder not by 100 mesh sieves is dropped into multi-function extractor and extracts twice, first time adds weight portion 8-10 times amount soak by water 1-3 hour, and second time adds weight portion 6-10 times amount soak by water 1-3 hour, merges twice decocting liquid, filters to get filtrate; The heating of gained filtrate is concentrated into pasty state, and after putting into the oven dry of 80 DEG C, baking oven, room temperature cools, and grinds to form fine powder b;
Step 3: call in glycerol after being mixed with fine powder b by fine powder a and make liniment.
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