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CN105434897A - Chinese herbal medicine composition for treating lumbar disc herniation and preparation method thereof - Google Patents

Chinese herbal medicine composition for treating lumbar disc herniation and preparation method thereof Download PDF

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Publication number
CN105434897A
CN105434897A CN201510923650.8A CN201510923650A CN105434897A CN 105434897 A CN105434897 A CN 105434897A CN 201510923650 A CN201510923650 A CN 201510923650A CN 105434897 A CN105434897 A CN 105434897A
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parts
radix
medicine composition
preparation
chinese herbal
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王斌胜
李岩
郑秋生
丁宝刚
于晓飞
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Binzhou Medical College
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Binzhou Medical College
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/58Reptiles
    • A61K35/583Snakes; Lizards, e.g. chameleons
    • AHUMAN NECESSITIES
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    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/32Bones; Osteocytes; Osteoblasts; Tendons; Tenocytes; Teeth; Odontoblasts; Cartilage; Chondrocytes; Synovial membrane
    • AHUMAN NECESSITIES
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K36/185Magnoliopsida (dicotyledons)
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    • A61K36/25Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/254Acanthopanax or Eleutherococcus
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/25Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
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    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/286Carthamus (distaff thistle)
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    • A61K36/34Campanulaceae (Bellflower family)
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481Astragalus (milkvetch)
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    • A61K36/185Magnoliopsida (dicotyledons)
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    • A61K36/67Piperaceae (Pepper family), e.g. Jamaican pepper or kava
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    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/71Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH

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Abstract

The invention discloses a Chinese herbal medicine composition for treating lumbar disc herniation and a preparation method thereof. The preparation method comprises weighing 30 parts of garter snake, 30 parts of radix astragali, 10 parts of safflower, 30 parts of wolfberry, 100 parts of rhizoma drynariae, 30 parts of cassia twig, 100 parts of Schizophragma integrifolium, 20 parts of deer-horn gelatin, 50 parts of suberect spatholobus stem, 100 parts of pilose asiabell root, 50 parts of radix angelicae sinensis, 20 parts of cortex acanthopanacis, 20 parts of pseudo-ginseng, 20 parts of pawpaw, 20 parts of gastrodia elata, 20 parts of white ginseng, 20 parts of clematis root and 50 parts of kadsura pepper stem, weighing liquor with alcoholic strength of 45-55 degrees and immersing the materials in the liquor according to a mass ratio of 1: 5000, wherein the safflower is packaged individually, then the packaged safflower and other Chinese herbal medicines are immersed together and are stood for two weeks and the safflower is taken out. The Chinese herbal medicine composition solves the problem that the prior art produces large operation wounds, has no definite non-operative treatment effects, has a high recurrence rate and a complex drug preparation process and causes patient intolerance to a drug smell.

Description

A kind of herbal composite for the treatment of prolapse of lumbar intervertebral disc and preparation method thereof
Technical field
The invention belongs to Chinese medicinal composition preparation technical field, relate to a kind of herbal composite for the treatment of prolapse of lumbar intervertebral disc and preparation method thereof.
Background technology
Prolapse of lumbar intervertebral disc (lumbardischerniation, LDH, to dash forward disease hereinafter referred to as waist) be a kind of common clinical, frequently-occurring disease, be one of modal cause of disease of lumbago and skelalgia, the treatment of current prolapse of lumbar intervertebral disc can be divided into non-operative treatment and operative therapy substantially.In operative therapy, the operation of Wicresoft's MED and open surgery are the technology of two kinds of comparative maturities, there is the shortcomings such as hemorrhage many, wound is large, spinal column Sagittal balance is destroyed in exploitation operation, and postoperative patient complication is many, slow [the DattaG of rehabilitation, GnanalinghamKK, PetersonD, etal.Backpainanddisabilityafterlumbarlaminectomy:isthere arelationshiptomuscleretraction [J] .Neurosurgery, 2004,54 (6): 1413-20, discussion1420.]; Now comparatively ripe percutaneous intervertebral foramina technology (PTED) then has that instrument and equipment requirement is accurate, technology grasp comparatively difficulty, increase medical worker's radiation exposure, thoroughly cannot extract the shortcoming [LeglandE such as the higher disc tissue in position, HoppeE.Dischemiation-inducedsciatica:medicalorsurgicaltr eatment [J] .Spine, 2008,15 (3): 285-293.].Non-surgical treatment comprises acupuncture and moxibustion treatment, traction treatment, PLDD, the intradiscal electrothermal treatment, intervertebral disc Ozone ablation art and Inferior turbinate hypertrophy therapy etc.Most patient can be eased through non-operative treatment or improve, its main theory and clinical foundation are heavily absorption after intervertebral disk hernia and reduce [ChangYJ, Hsieh, AlanH, etal.Effectivenessoffourconservativetreatmentsforsubactu telowbackpain [J] Spine, 2002,27 (11): 1142-1149], except Damage of cauda nerve continues the patient that increases the weight of, the LDH of first attack all should take non-operative treatment as first-selection.[Zhu Guowen, treatment of lumbar disc herniation progress [J] Zhejiang combination of Chinese and Western medicine magazine, 2015,25 (5): 522-525] according to statistics the prolapse of lumbar intervertebral disc of about 85-90% patient through actively suitable non-operative treatment all can obtain comparatively satisfied recovery [Nan Dengkun. rehabilitation medicine [M]. the 3rd edition: People's Health Publisher publishes, 2005.284].And research display Chinese medicine decoction in recent years takes the degree of the reaction that can reduce inflammation orally, shorten inflammatory phase and the formation alleviating connective tissue, promote the recovery of degenerated nerve fibers, reduce increasing of glial cell and gtelatinous fibre, lessen scar formation to the extruding of surrounding tissue to reach lenitive object [Tang Fuyu, Huang Chengjun, Xu Min, Chinese medicine Deng prolapse of lumbar intervertebral disc is in progress [J]. Chinese orthopedics and traumatology of Chinese medicine magazine, 2009,17 (5): 68-69.].Intervertebral disc prolapse belongs to the category of Chinese medical ' arthralgia syndrome ', " lumbago and skelalgia ", its morbidity is main and suffer from a deficiency of the kidney, cold-damp is invaded, lumbar strain is closely related, cold-damp of suffering from a deficiency of the kidney phlegm stagnation in collateral is its main pathogenesis, and suffering from a deficiency of the kidney [Luo Min. the progress [J] of integrative therapy lumbago and skelalgia. TCM clinical study, 2014,6 (13): 145-147.].Prolapse of lumbar intervertebral disc be the course of disease long, be easy to the chronic disease that recurs, therefore Chinese medicine for oral administration treatment also having boil medicine take time and effort, the bitter patient of flavour of a drug is difficult to the shortcomings such as tolerance.
Summary of the invention
The object of this invention is to provide a kind of herbal composite for the treatment of prolapse of lumbar intervertebral disc, solve that the operation wound that exists in prior art is large, non-operative treatment uncertain therapeutic efficacy is cut, easily recur, medicament prepares the problem that loaded down with trivial details and patient can not tolerate medicament abnormal smells from the patient.
The technical solution adopted in the present invention is, a kind of herbal composite for the treatment of prolapse of lumbar intervertebral disc, comprises following component according to weight portion: Zaocys 30 parts, the Radix Astragali 30 parts, 10 parts, Flos Carthami, Fructus Lycii 30 parts, Rhizoma Drynariae 100 parts, Ramulus Cinnamomi 30 parts, Cortex schizophragmatis integrifolii radicis 100 parts, Colla cornus cervi 20 parts, Caulis Spatholobi 50 parts, Radix Codonopsis 100 parts, Radix Angelicae Sinensis 50 parts, Cortex Acanthopancis 20 parts, 20 parts, Radix Notoginseng, Fructus Chaenomelis 20 parts, 20 parts, Rhizoma Gastrodiae, Radix Ginseng 20 parts, Radix Clematidis 20 parts, Caulis Piperis Kadsurae 50 parts.
Another technical scheme of the present invention is, a kind of preparation method for the treatment of the herbal composite of prolapse of lumbar intervertebral disc, comprises the following steps:
Step 1, weighing: weigh following component according to mass parts: Zaocys 30 parts, the Radix Astragali 30 parts, 10 parts, Flos Carthami, Fructus Lycii 30 parts, Rhizoma Drynariae 100 parts, Ramulus Cinnamomi 30 parts, Cortex schizophragmatis integrifolii radicis 100 parts, Colla cornus cervi 20 parts, Caulis Spatholobi 50 parts, Radix Codonopsis 100 parts, Radix Angelicae Sinensis 50 parts, Cortex Acanthopancis 20 parts, 20 parts, Radix Notoginseng, Fructus Chaenomelis 20 parts, 20 parts, Rhizoma Gastrodiae, Radix Ginseng 20 parts, Radix Clematidis 20 parts, Caulis Piperis Kadsurae 50 parts;
Step 2, weighing alcoholic strength are the Chinese liquor of 45-55 degree, and wherein, every part of medicine in step 1 and the mass ratio of Chinese liquor are 1:5000;
Step 3, with step 2 measure Chinese liquor concoct soak above-mentioned each component, wherein Flos Carthami list bag, then with his medicine total immersion, leave standstill 2 weeks, taking-up Flos Carthami, to obtain final product.
The invention has the beneficial effects as follows compared with the existing Therapeutic Method of intervertebral disc prolapse, the present invention has the following advantages: 1. treat conveniently: the present invention selects the Chinese liquor of 45-55 degree, for the mixture of second alcohol and water, ethanol is organic solvent, through 2 weeks infuses, effective ingredient in Chinese medicine composition can better be extracted, and therefore patient only needs the Liquor infusion 50ml of twice oral Chinese medicine composition every day; 2. medicament is easy to prepare: soaked 2 weeks disposable for this Chinese medicine composition to add in about 50 degree Chinese liquor; 3. stable curative effect: have multiple blood circulation promoting and blood stasis dispelling, cold relieving dredging collateral Chinese medicine in this Chinese medicine composition, effectively can alleviate the inflammatory reaction degree that caused by prolapse of lumbar intervertebral disc and the extruding to surrounding tissue, thus effective alleviating pain; There is in this Chinese medicine composition the multiple Chinese medicine nourished blood of tonifying Qi of the kidney, by tonification healthy energy, reduce the probability of palindromia; Therefore it is outstanding to take this Chinese medicine composition curative effect, not easily recurs.Preclinical result of study show, 50 routine lumbar intervertebral disc patients fully recover 16 example, effective 19 example, effective 12 example, invalid 3 example, total effective rate reaches 94%.
Detailed description of the invention
The invention provides a kind of herbal composite for the treatment of prolapse of lumbar intervertebral disc, comprise following component according to weight portion: Zaocys 30 parts, the Radix Astragali 30 parts, 10 parts, Flos Carthami, Fructus Lycii 30 parts, Rhizoma Drynariae 100 parts, Ramulus Cinnamomi 30 parts, Cortex schizophragmatis integrifolii radicis 100 parts, Colla cornus cervi 20 parts, Caulis Spatholobi 50 parts, Radix Codonopsis 100 parts, Radix Angelicae Sinensis 50 parts, Cortex Acanthopancis 20 parts, 20 parts, Radix Notoginseng, Fructus Chaenomelis 20 parts, 20 parts, Rhizoma Gastrodiae, Radix Ginseng 20 parts, Radix Clematidis 20 parts, Caulis Piperis Kadsurae 50 parts.
Each component span optimizes gained in clinical middle summary for many years, and in this scope, value is fixed, and curative effect is reliable and stable, not easily recurs; Be greater than this scope and may occur certain side effect in clinical practice, as gastrointestinal irritation, hepatorenal damage etc.; Be less than this scope, then curative effect can be caused to reduce.
The present invention also provides a kind of preparation method for the treatment of the herbal composite of prolapse of lumbar intervertebral disc, comprises the following steps:
Step 1, weighing: weigh following component according to mass parts: Zaocys 30 parts, the Radix Astragali 30 parts, 10 parts, Flos Carthami, Fructus Lycii 30 parts, Rhizoma Drynariae 100 parts, Ramulus Cinnamomi 30 parts, Cortex schizophragmatis integrifolii radicis 100 parts, Colla cornus cervi 20 parts, Caulis Spatholobi 50 parts, Radix Codonopsis 100 parts, Radix Angelicae Sinensis 50 parts, Cortex Acanthopancis 20 parts, 20 parts, Radix Notoginseng, Fructus Chaenomelis 20 parts, 20 parts, Rhizoma Gastrodiae, Radix Ginseng 20 parts, Radix Clematidis 20 parts, Caulis Piperis Kadsurae 50 parts.
Step 2, weighing alcoholic strength are the Chinese liquor of 45-55 degree, and wherein, every part of medicine in step 1 and the mass ratio of Chinese liquor are 1:5000;
Step 3, with step 2 measure Chinese liquor and concoct and soak above-mentioned each component, wherein Flos Carthami list bag, then with his medicine total immersion, leave standstill 2 weeks, take out Flos Carthami, prepare and treat the herbal composite of prolapse of lumbar intervertebral disc.
Clinic Case
Father inventor, in JIUYUE, 08 is because working accidentally, occurs lumbago, is radiated to below right knee joint, hurt like hell, walk upright 30 meters and namely can not adhere to, lumbago outbreak was that hunchback bends over nearly 90 degree less than 2 months.November is diagnosed as prolapse of lumbar intervertebral disc to Yantai Traditional Chinese Medical-science (TCM) Hospital, and CT shows waist 4,5 annuler bulge.Then start to take traditional Chinese medical science compositions of the present invention, after 1 week, pain is alleviated gradually, and total pain relief after 3 weeks, also can walk upright.Take this Chinese medicine composition two course for the treatment of then altogether, adhere to every year taking two courses for the treatment of so far afterwards.In 7 years that take this Chinese medicine composition, not there is lumbago and skelalgia, and feel muscle power enhancing.
There is violent left side lower limb pain in October, 10 in mother inventor, in radioactivity, takes action limited, and local village doctor examines as sciatica, gives anti-inflammatory analgesic class Drug therapy, can only alleviating pain, can not stop recurrent pain.Then see a doctor to Yantai Traditional Chinese Medical-science (TCM) Hospital, CT shows lumbar vertebra severe lumbar stenosis, waist 4,5 intervertebral disk hernia.Hospital's suggestion operative treatment, easily recurs the suggestion that do not undergo surgery because fearing in postoperative complication and the state of an illness.After starting to take Chinese medicine composition of the present invention in October, 10, pain alleviates gradually, total pain relief after 3 weeks, adheres to every year taking two courses for the treatment of so far afterwards.In 5 years that take this Chinese medicine composition, not there is lumbago and skelalgia, and feel muscle power enhancing.The coronary heart diseases and angina pectoris attack times suffered from for many years also reduces gradually.
Zhao, old women, 14 year autumn occurred that left side hip connected and thigh pain, because of handicapped, senile gonarthritis recurrence for many years, takes two courses for the treatment of of Chinese medicine composition of the present invention, hip, huckle, the gonalgia are all alleviated, and readme muscle power is also better than in the past.
Above patient takes this Chinese medicine composition, does not occur toxic and side effects and untoward reaction.

Claims (2)

1. treat a herbal composite for prolapse of lumbar intervertebral disc, it is characterized in that, comprise following component according to weight portion: Zaocys 30 parts, the Radix Astragali 30 parts, 10 parts, Flos Carthami, Fructus Lycii 30 parts, Rhizoma Drynariae 100 parts, Ramulus Cinnamomi 30 parts, Cortex schizophragmatis integrifolii radicis 100 parts, Colla cornus cervi 20 parts, Caulis Spatholobi 50 parts, Radix Codonopsis 100 parts, Radix Angelicae Sinensis 50 parts, Cortex Acanthopancis 20 parts, 20 parts, Radix Notoginseng, Fructus Chaenomelis 20 parts, 20 parts, Rhizoma Gastrodiae, Radix Ginseng 20 parts, Radix Clematidis 20 parts, Caulis Piperis Kadsurae 50 parts.
2. treat a preparation method for the herbal composite of prolapse of lumbar intervertebral disc, it is characterized in that, comprise the following steps:
Step 1, weighing: weigh following component according to mass parts: Zaocys 30 parts, the Radix Astragali 30 parts, 10 parts, Flos Carthami, Fructus Lycii 30 parts, Rhizoma Drynariae 100 parts, Ramulus Cinnamomi 30 parts, Cortex schizophragmatis integrifolii radicis 100 parts, Colla cornus cervi 20 parts, Caulis Spatholobi 50 parts, Radix Codonopsis 100 parts, Radix Angelicae Sinensis 50 parts, Cortex Acanthopancis 20 parts, 20 parts, Radix Notoginseng, Fructus Chaenomelis 20 parts, 20 parts, Rhizoma Gastrodiae, Radix Ginseng 20 parts, Radix Clematidis 20 parts, Caulis Piperis Kadsurae 50 parts;
Step 2, weighing alcoholic strength are the Chinese liquor of 45-55 degree, and wherein, every part of medicine in step 1 and the mass ratio of Chinese liquor are 1:5000;
Step 3, with step 2 measure Chinese liquor concoct soak above-mentioned each component, wherein Flos Carthami list bag, then with his medicine total immersion, leave standstill 2 weeks, taking-up Flos Carthami, to obtain final product.
CN201510923650.8A 2015-12-12 2015-12-12 Chinese herbal medicine composition for treating lumbar disc herniation and preparation method thereof Pending CN105434897A (en)

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* Cited by examiner, † Cited by third party
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CN109528909A (en) * 2019-01-14 2019-03-29 浴康中医保健养生(江苏)有限公司 It is a kind of for treating the external drug of protrusion of lumber intervertebral disc and spinal canal stenosis

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Publication number Priority date Publication date Assignee Title
CN102579652A (en) * 2012-03-22 2012-07-18 桂林天和药业股份有限公司 Medicine for treating lumbar disc herniation and preparation method thereof
CN102600327A (en) * 2012-03-06 2012-07-25 爨新德 Ostealgia treating capsule

Patent Citations (2)

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Publication number Priority date Publication date Assignee Title
CN102600327A (en) * 2012-03-06 2012-07-25 爨新德 Ostealgia treating capsule
CN102579652A (en) * 2012-03-22 2012-07-18 桂林天和药业股份有限公司 Medicine for treating lumbar disc herniation and preparation method thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109528909A (en) * 2019-01-14 2019-03-29 浴康中医保健养生(江苏)有限公司 It is a kind of for treating the external drug of protrusion of lumber intervertebral disc and spinal canal stenosis

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Application publication date: 20160330