CN104688999A - Chinese herbal preparation for immunity enhancement - Google Patents

Abstract

The invention discloses a Chinese herbal preparation for immunity enhancement; in raw materials, longleaf luckyweed flowers, fiveleaf akebia fruits, herba cistanche, lotus plumules, longan aril, salvia miltiorrhiza and rhizoma cyperi are adopted as principal herbs and ministerial herbs for regulating qi and blood, clearing away the heart-fire to relieve restlessness, regulating vital energy to dispel melancholy, harmonizing stomach to aid digestion and nourishing the five internal organs; frankincense, hawthorn, honey-fried licorice root, platycladi seed, barbados aloe, ginseng flower and cordyceps sinensis are adopted as adjuvant herbs for strengthening the functions of the principal herbs and ministerial herbs, promoting qi circulation to remove stagnation from spleen and stomach, nourishing qi and blood, strengthening tendons and bones, tonifying heart and spleen and nourishing the blood and tranquilization; and the herbs are combined to powerfully treat hypoimmunity caused by kidney essence deficiency and dual depletion of qi and blood.

Description

A kind of Chinese medicine preparation improving immunity

Technical field

The present invention relates to the medicinal preparation containing deriving from plant, animal or raw mineral materials, particularly a kind of Chinese medicine preparation improving immunity and preparation method thereof.

Background technology

Immunity is the defense mechanism of human body self, is human bioequivalence and any foreign body (virus, antibacterial etc.) eliminating external intrusion.Process is old and feeble, damage, the ability of mutant cell and virus infected cell in the own cells of dead, degeneration and identification and handling body.Immunology Today is thought, immunity is the physiological reaction of human bioequivalence and eliminating " dissident ".

The health of hypoimmunity is easy to infected or cancer stricken, and immunity is extraordinary also can produce insalubrious result, as caused anaphylaxis, autoimmune disease etc.

A variety of causes makes immune system normally can not play protective effect, and in the case, very easily cause the infection such as antibacterial, virus, fungus, therefore hypoimmunity the most directly shows is exactly liable to illness.Because of often ill, increased the weight of the consumption of body, thus generally have a delicate constitution, the reduction of malnutrition, lethargy, fatigue and weak, appetite, the performance such as sleep disorder.Sick, having an injection to take medicine just gets married that normal potluck is at every turn sick all will could be recovered for a long time, and usually recurrent exerbation.If things go on like this can cause health and intelligent development bad, also easily bring out major disease, should be supplemented some when hypoimmunity containing the high food of zinc, selenium and protein more, effectively can improve immunity of organisms, enhancing immunity.

Underlying causes is that hypoimmunity or immunity are unsound.When immune function of human body imbalance, or when immune system is unsound, following point will recurrent exerbation: flu recurrent exerbation, tonsillitis recurrent exerbation, asthma recurrent exerbation, bronchitis recurrent exerbation, pneumonia recurrent exerbation, diarrhoea recurrent exerbation, so necessarily can't neglect.

The method of current raising immunity is confined to give nutrition, and from food, community's energy improves immunity; Take exercises raising immunity, but it is helpful to prevention to improve immunity to absorb energy from food, to regulating the patient of hypoimmunity not have help, therefore research and development are a kind of absorbs soon, and the oral formulations of the enhancing raising immunity of instant effect is necessary.

Summary of the invention

Technical problem to be solved by this invention is, provides that a kind of formula is simple, processing technology is easy, and the little and convenient drug administration of toxic and side effects, medicament is easy to manufacture, new drug with low cost.The present invention has QI and blood regulating, clear away heart-fire relieving restlessness, regulate the flow of vital energy resolving depression, stomach function regulating is aid digestion, supports effects of the five internal organs, mainly for the sub-health population with hypoimmunity, effectively can take into account the discomfort that whole body is relevant while improving promoting extremities blood circulation, improve the quality of life of patient.The present invention adopts the Chinese crude drug of different properties, has carried out scientific compatibility, and can reach desirable therapeutic effect, safety, processing technology is easy, and toxic and side effects is little, and convenient drug administration, medicament is easy to manufacture, with low cost.

For solving the problems of the technologies described above, the invention provides a kind of Chinese medicine preparation improving immunity, its crude drug be with Flos Spatholirionis longifolii, Fructus Akebiae, Herba Cistanches, Plumula Nelumbinis, Arillus Longan, Radix Salviae Miltiorrhizae, the Rhizoma Cyperi medicine QI and blood regulating that is the monarch and his subjects, clear away heart-fire relieving restlessness, regulate the flow of vital energy resolving depression, stomach function regulating is aid digestion, support the five internal organs; With Olibanum, Fructus Crataegi, Radix Glycyrrhizae Preparata, Semen Platycladi, Aloe, Flos Ginseng, Radix Ginseng Rubra, the medicine of Cordyceps for assisting a ruler in governing a country, strengthen effect of monarch-minister drug, promoting the circulation of QI to alleviate the stagnation in middle-JIAO, nourishing qi and blood, strengthening the tendons and bones, invigorating the heart and spleen, nourishing blood to tranquillize the mind, all medicines share the hypoimmunity caused for deficiency of kidney-essence, deficiency of both QI and blood strong therapeutical effect.

The property of medicine and the pharmacology of medicine selected by the present invention are respectively:

Flos Spatholirionis longifolii:

[nature and flavor] are puckery, cool.

Effect of [function cures mainly] Flos Spatholirionis longifolii is QI and blood regulating, pain relieving, and treatment menoxenia, nervous headache and constipation, have toxin expelling effect.

Fructus Akebiae:

[function cures mainly] pathogenic fire purging row water, promoting blood circulation.For hot urination, stranguria with turbid discharge, edema, irritable feverish sensation in the chest, sore throat pharyngalgia, inflexible pain all over, women's amenorrhea, galactostasis.

Herba Cistanches:

[nature and flavor] are warm in nature, sweet in the mouth, salty;

[effect] supports the five internal organs, reinforcing YIN-essence, beneficial vital essence.

Arillus Longan:

[nature and flavor] are warm in nature, and taste is sweet.

[function cures mainly] invigorating the heart and spleen, nourishing blood to tranquillize the mind.For insufficiency of vital energy and blood, severe palpitation, forgetful insomnia, blood deficiency and yellow complexion.

Radix Salviae Miltiorrhizae:

[meridian distribution of property and flavor] is bitter, is slightly cold.GUIXIN, Liver Channel.

[function cures mainly] stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, clear away heart-fire relieving restlessness.For menoxenia, amenorrhea dysmenorrhea, lump in the abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia; Hepatosplenomegaly, angina pectoris." book on Chinese herbal medicine justice ": Radix Salviae Miltiorrhizae, being slightly cold of " herbal classic " meaning, TAO Hong-Jing has doubted it by mistake, and Miao's secondary alcohol also doubts it, and stupid to a stone is transform tepor into." herbal classic ": main trusted subordinate's pathogen, borborygmus are faint as leaked water, and cold and heat gather; Broken disease, except abdominal mass, stops stuffy sensation with restlessness, QI invigorating." WU Pu Bencao ": control cardiac and abdominal pain." not Lu ": nourish blood, remove trusted subordinate's obstinate disease stagnation of QI, stiffness along the spinal column, foot numbness; Except wind, Xing stays heat, takes sharp people for a long time.TAO Hong-Jing: stain beverage it, treat migratory arthralgia." property of medicine opinion ": control flaccidity of the lower limbs, pain numbness, main attacked by pestiferous factors; Control stomachache, gas is done sound ring and is shouted." Japan hanako materia medica ": sedate of reposing, tonneau GUAN-pulse.Control cold and hot labor, arthralgia, extremity are unsuccessful; Evacuation of pus pain relieving, granulation promoting is put on flesh; Broken stagnated blood, mends new hemopoietic; Peaceful tire, fall stillborn fetus; Under hemostasis metrorrhagia and leukorrhagia, adjust married woman's passages through which vital energy circulates irregular, blood evil thought is tired of; Malignant boil scabies, wart is gone to live in the household of one's in-laws on getting married toxic swelling, erysipelas; Headache, acute conjunctivitis, hot temperature is mad vexed." the southern regions of the Yunnan Province book on Chinese herbal medicine ": reinforcing the heart sedate, calming heart and tranquilizing mind.Control forgetful palpitation with a distress feeling, palpitation with fear is insomnia." detailed outline ": invigorate blood circulation, logical percardium.Control colic." choosing of Yunnan Chinese herbal medicine ": promoting blood circulation to remove blood stasis, sedation-analgesia.Control menoxenia, dysmenorrhea, rheumatic arthralgia, metrorrhagia, spit blood, mastitis, carbuncle.

Olibanum: regulating QI, invigorates blood circulation, and pain relieving chases after poison.Antibacterial, restrain, flatulence of dispelling, promote wound scab, promote cytoactive, profit digestion, diuresis, calmness, benefit body, sharp uterus, control wound.

Rhizoma Cyperi:

[nature and flavor] pungent micro-hardship is sweet, flat.

[function cures mainly] regulates the flow of vital energy resolving depression, menstruction regulating and pain relieving.For stagnation of QI due to depression of the liver, breast, the side of body, abdominal distention, dyspepsia, menoxenia, amenorrhea dysmenorrhea, colic of cold type is suffered from abdominal pain, distending pain of the breast.

Radix Glycyrrhizae Preparata:

[meridian distribution of property and flavor] sweet in the mouth, flat; GUIXIN, lung, spleen, stomach warp.

[function cures mainly] spleen reinforcing stomach function regulating, Yiqi and vein recovery.For weakness of the spleen and stomach, fatigue and weakness, severe palpitation, irregularly intermittent and regularly intermittent pulse, can separate Radix Aconiti Lateralis Preparata poison.

Plumula Nelumbinis:

[nature and flavor] are bitter, cold, nontoxic;

[effect] clears away heart-fire, and reduces phlegm and internal heat, hemostasis, arresting seminal emission.Control vexed, thirsty, spit blood, seminal emission, conjunctival congestion and swelling pain." book on Chinese herbal medicine is new again ": clearing away heart-fire, suppressing the hyperactive liver fire, lung-fire, falls in purgation of spleen excess fire.Relieve summer heat relieving restlessness, promoting the production of body fluid to quench thirst, controls order redness.

Fructus Crataegi:

[nature and flavor] sour in the mouth, sweet, slightly warm in nature.

[function cures mainly] appetite-stimulating indigestion-relieving, change stagnant removing food stagnancy, promoting blood circulation to remove blood stasis, circulation of qi promoting of reducing phlegm.For meat stagnant long-pending, lump in the abdomen, abdominal distention feeling of fullness, stasis blocking stomachache, phlegm retention, have loose bowels, discharging fresh blood stool etc.

Semen Platycladi:

[nature and flavor]: sweet, flat.GUIXIN, kidney, large intestine channel.

[function cures mainly]: tranquilizing by nourishing the heart, loosening bowel to relieve constipation.For restlessness of asrhenia type and insomnia, severe palpitation, the diseases such as dryness of the intestine constipation.

Aloe: the Pharmacopoeia of the People's Republic of China (version one in 2000) say in this way nature and flavor with return through: bitter, cold; Return liver, stomach, large intestine channel; Function with cure mainly: removing heat from the liver, relieving constipation; For constipation, infantile malnutrition, infantile convulsion; External treatment exudative dermatitis.Compendium of Material Medica says nature and flavor in this way: bitter, cold, nontoxic; Cure mainly: hot blast is unhappy, steam between septum pectorale, improving eyesight relieving palpitation, children epilepsy infantile convulsion, treat five kinds of child malnutrition, kill three worms and the sick skin ulcer fistula of hemorrhoid, separate Fructus Crotonis poison."The Chinese material medica, concentrated herbal medicine of the Chinese material medica will aloe health care function summarized as: (1) drainage, namely runchang purge;Diction of adjusting human body's immunity;(3) resistance to swelling nodule;(4) to protect the liver;5] stomach damage resistance;[6] antibacterial;Once the repair tissue damage;Being supplied to the protection of the skin.Hardship, cold.Return liver, stomach, large intestine channel.Functions and indications: drainage, namely runchang purge;Adjust immunity;Resistance to swelling nodule;To protect the liver;Gastric damage resistance;Antibacterial;Repair tissue damage;The protection of the skin.

Flos Ginseng:

[nature and flavor]: bitterness Hui Tian, have the pungent sweet taste of Radix Ginseng.

[function]: supplement vitality of human body, regain one's strength, strengthens body immunity.

Radix Ginseng Rubra:

[meridian distribution of property and flavor] sweet, micro-hardship, temperature, returns spleen, lung, heart channel;

[function cures mainly] strongly invigorating primordial QI, multiple arteries and veins takes off admittedly, nourishing qi to stop.For weak body and prostration, cold extremities faint pulse, QI failing to control blood, metrostaxis; Heart failure, cardiogenic shock.

Cordyceps:

[nature and flavor] sweet in the mouth, property is put down.

[function] have nourishing YIN and moistening the lung, the kidney invigoratingthe effect of tonifying YANG, so can adjust as nourishing the lung and kidney, hemostasis and phlegm, guarantor's lung, change dysentery, stop that consumptive disease is coughed etc. the food mended.Cordycep includes cordycepic acid.Vitamin B12, fat, albumendeng.Cordyceps property is sweet, wen Ping, nontoxic, be famous strengthening by means of tonics medicine, conventional meat boiled dinner, has the effect that tonify deficiency is healthy and strong.Be applicable to treatment insufficiency of lung-QI and deficiency of both the lung and kidney, pulmonary tuberculosisdeng caused by spitting of blood or sputum mixed with blood, cough.Breathe hard, night sweat etc., right suffer from a deficiency of the kidneysexual impotence, waist knee joint ache etc. also have good curative effect, the excellent tonic product of the person that is also oldaged physically weak.

A kind of Chinese medicine preparation improving immunity, it is characterized in that, in described Chinese medicine preparation, the ratio of weight and number of various crude drug is: Flos Spatholirionis longifolii 5-10 part, Fructus Akebiae 5-10 part, Herba Cistanches 5-10 part, Plumula Nelumbinis 5-10 part, Arillus Longan 5-10 part, Radix Salviae Miltiorrhizae 5-10 part, Rhizoma Cyperi 5-10 part, Olibanum 5-10 part, Fructus Crataegi 5-10 part, Radix Glycyrrhizae Preparata 5-10 part, Semen Platycladi 5-10 part, Aloe 5-10 part, Flos Ginseng 5-10 part, Radix Ginseng Rubra 5-10 part, Cordyceps 5-10 part.

A kind of Chinese medicine preparation improving immunity, it is characterized in that, in described Chinese medicine preparation, the ratio of weight and number of various crude drug is: Flos Spatholirionis longifolii 6-8 part, Fructus Akebiae 6-8 part, Herba Cistanches 6-8 part, Plumula Nelumbinis 6-8 part, Arillus Longan 6-8 part, Radix Salviae Miltiorrhizae 6-8 part, Rhizoma Cyperi 6-8 part, Olibanum 6-8 part, Fructus Crataegi 6-8 part, Radix Glycyrrhizae Preparata 6-8 part, Semen Platycladi 6-8 part, Aloe 6-8 part, Flos Ginseng 6-8 part, Radix Ginseng Rubra 6-8 part, Cordyceps 6-8 part.

A kind of Chinese medicine preparation improving immunity, it is characterized in that, in described Chinese medicine preparation, the ratio of weight and number of various crude drug is: Flos Spatholirionis longifolii 7 parts, Fructus Akebiae 7 parts, Herba Cistanches 7 parts, Plumula Nelumbinis 7 parts, Arillus Longan 7 parts, Radix Salviae Miltiorrhizae 7 parts, Rhizoma Cyperi 7 parts, Olibanum 7 parts, Fructus Crataegi 7 parts, Radix Glycyrrhizae Preparata 7 parts, Semen Platycladi 7 parts, Aloe 7 parts, Flos Ginseng 7 parts, Radix Ginseng Rubra 7 parts, Cordyceps 7 parts.

Improve a preparation method for the Chinese medicine preparation of immunity, it is characterized in that: described Chinese medicine preparation dosage form is that the preparation method of capsule comprises:

Step a, puts into 10 times of water gagings by formula proportion by crude drug, heating and refluxing extraction 3 times, each 45 minutes ~ 1 hour, is merged by 3 extracting solution and leaves standstill;

Step b, by above-mentioned decompression filtrate recycling ethanol and to be concentrated into liquor strength be 0.4g crude drug/mL, after sucking filtration, when the relative density of filtrate is about 20 DEG C 1.06; Above-mentioned filtrate is the macroporous adsorptive resins of 10L through volume, first uses deionized water or the distilled water eluting of 10 times of resin column volumes, then uses 95% ethanol elution of 5 times of resin column volumes, collects ethanol elution, removes solvent, obtains raw material medicated powder, incapsulate.

Detailed description of the invention:

Embodiment 1, formula: Flos Spatholirionis longifolii 5g, Fructus Akebiae 5g, Herba Cistanches 5g, Plumula Nelumbinis 5g, Arillus Longan 5g, Radix Salviae Miltiorrhizae 5g, Rhizoma Cyperi 5g, Olibanum 5g, Fructus Crataegi 5g, Radix Glycyrrhizae Preparata 5g, Semen Platycladi 5g, Aloe 5g, Flos Ginseng 5g, Radix Ginseng Rubra 5g, Cordyceps 5g.

Preparation method comprises:

Step a, puts into 10 times of water gagings by formula proportion by crude drug, heating and refluxing extraction 3 times, each 45 minutes ~ 1 hour, is merged by 3 extracting solution and leaves standstill;

Step b, by above-mentioned decompression filtrate recycling ethanol and to be concentrated into liquor strength be 0.4g crude drug/mL, after sucking filtration, when the relative density of filtrate is about 20 DEG C 1.06; Above-mentioned filtrate is the macroporous adsorptive resins of 10L through volume, first uses deionized water or the distilled water eluting of 10 times of resin column volumes, then uses 95% ethanol elution of 5 times of resin column volumes, collects ethanol elution, removes solvent, obtains raw material medicated powder, incapsulate.

Usage and consumption: every day three times, one time four, warm water delivery service one week is a course for the treatment of.

Treatment model case:

Patient, female, 15 years old, middle school student, usually caught a cold, and all can catch a cold season every month throughout the year, symptom differs, and delays school work, start a course for the treatment of of oral Traditional Chinese medicine preparation capsule of the present invention one to period of changing according to the season, and within 1 year, did not catch a cold once.

Embodiment 2, formula: Flos Spatholirionis longifolii 6g, Fructus Akebiae 6g, Herba Cistanches 6g, Plumula Nelumbinis 6g, Arillus Longan 6g, Radix Salviae Miltiorrhizae 6g, Rhizoma Cyperi 6g, Olibanum 6g, Fructus Crataegi 6g, Radix Glycyrrhizae Preparata 6g, Semen Platycladi 6g, Aloe 6g, Flos Ginseng 6g, Radix Ginseng Rubra 6g, Cordyceps 6g.

Preparation method comprises:

Step a, puts into 10 times of water gagings by formula proportion by crude drug, heating and refluxing extraction 3 times, each 45 minutes ~ 1 hour, is merged by 3 extracting solution and leaves standstill;

Step b, by above-mentioned decompression filtrate recycling ethanol and to be concentrated into liquor strength be 0.4g crude drug/mL, after sucking filtration, when the relative density of filtrate is about 20 DEG C 1.06; Above-mentioned filtrate is the macroporous adsorptive resins of 10L through volume, first uses deionized water or the distilled water eluting of 10 times of resin column volumes, then uses 95% ethanol elution of 5 times of resin column volumes, collects ethanol elution, removes solvent, obtains raw material medicated powder, incapsulate.

Usage and consumption: every day three times, one time four, warm water delivery service one week is a course for the treatment of.

Treatment model case:

Sex: man, the age: 52 years old, has a delicate constitution, hypoimmunity, and poor appetite, can't have dinner, after two courses for the treatment of of oral invention formulation, recovers normal, does not recur so far.

Embodiment 3, formula: Flos Spatholirionis longifolii 7g, Fructus Akebiae 7g, Herba Cistanches 7g, Plumula Nelumbinis 7g, Arillus Longan 7g, Radix Salviae Miltiorrhizae 7g, Rhizoma Cyperi 7g, Olibanum 7g, Fructus Crataegi 7g, Radix Glycyrrhizae Preparata 7g, Semen Platycladi 7g, Aloe 7g, Flos Ginseng 7g, Radix Ginseng Rubra 7g, Cordyceps 7g.

Preparation method comprises:

Step a, puts into 10 times of water gagings by formula proportion by crude drug, heating and refluxing extraction 3 times, each 45 minutes ~ 1 hour, is merged by 3 extracting solution and leaves standstill;

Step b, by above-mentioned decompression filtrate recycling ethanol and to be concentrated into liquor strength be 0.4g crude drug/mL, after sucking filtration, when the relative density of filtrate is about 20 DEG C 1.06; Above-mentioned filtrate is the macroporous adsorptive resins of 10L through volume, first uses deionized water or the distilled water eluting of 10 times of resin column volumes, then uses 95% ethanol elution of 5 times of resin column volumes, collects ethanol elution, removes solvent, obtains raw material medicated powder, incapsulate.

Usage and consumption: every day three times, one time four, warm water delivery service one week is a course for the treatment of.

Treatment model case: patient marquis so-and-so, women, 28 years old.In bank's work after graduating from university, bright and new beautiful before people, but bank's promotion pressure is very large, usually have a sleepless night, one to evening, lies on a bed and how also cannot sleep peacefully, almost every day is all panda eye, goes to work with large eye pouch, and work also often has and makes mistakes, poor appetite, can't have dinner, and oral Chinese medicine preparation of the present invention the symptom course for the treatment of is obviously improved, sleep is good, the mental status has been got well, after consolidated again a course for the treatment of, so far not recurrence.

Embodiment 4, formula: Flos Spatholirionis longifolii 8g, Fructus Akebiae 8g, Herba Cistanches 8g, Plumula Nelumbinis 8g, Arillus Longan 8g, Radix Salviae Miltiorrhizae 8g, Rhizoma Cyperi 8g, Olibanum 8g, Fructus Crataegi 8g, Radix Glycyrrhizae Preparata 8g, Semen Platycladi 8g, Aloe 8g, Flos Ginseng 8g, Radix Ginseng Rubra 8g, Cordyceps 8g.

Preparation method comprises:

Step a, puts into 10 times of water gagings by formula proportion by crude drug, heating and refluxing extraction 3 times, each 45 minutes ~ 1 hour, is merged by 3 extracting solution and leaves standstill;

Step b, by above-mentioned decompression filtrate recycling ethanol and to be concentrated into liquor strength be 0.4g crude drug/mL, after sucking filtration, when the relative density of filtrate is about 20 DEG C 1.06; Above-mentioned filtrate is the macroporous adsorptive resins of 10L through volume, first uses deionized water or the distilled water eluting of 10 times of resin column volumes, then uses 95% ethanol elution of 5 times of resin column volumes, collects ethanol elution, removes solvent, obtains raw material medicated powder, incapsulate.

Usage and consumption: every day three times, one time four, warm water delivery service one week is a course for the treatment of.

Treatment model case: female Hao patient women, 37 years old, driving school staff, feel fatigue throughout the year, weak, forgetful, brain is usually felt to swell, slice, thin piece brain does not have any problem yet to have gone to hospital to clap, doctor allows and has a good rest, and treatment: oral Chinese medicine preparation of the present invention, treats patient's transference cure after 15 days, after consolidate one month again, do not recur so far.

Embodiment 5, formula:

Flos Spatholirionis longifolii 10g, Fructus Akebiae 10g, Herba Cistanches 10g, Plumula Nelumbinis 10g, Arillus Longan 10g, Radix Salviae Miltiorrhizae 10g, Rhizoma Cyperi 10g, Olibanum 10g, Fructus Crataegi 10g, Radix Glycyrrhizae Preparata 10g, Semen Platycladi 10g, Aloe 10g, Flos Ginseng 10g, Radix Ginseng Rubra 10g, Cordyceps 10g.

Preparation method comprises:

Step a, puts into 10 times of water gagings by formula proportion by crude drug, heating and refluxing extraction 3 times, each 45 minutes ~ 1 hour, is merged by 3 extracting solution and leaves standstill;

Step b, by above-mentioned decompression filtrate recycling ethanol and to be concentrated into liquor strength be 0.4g crude drug/mL, after sucking filtration, when the relative density of filtrate is about 20 DEG C 1.06; Above-mentioned filtrate is the macroporous adsorptive resins of 10L through volume, first uses deionized water or the distilled water eluting of 10 times of resin column volumes, then uses 95% ethanol elution of 5 times of resin column volumes, collects ethanol elution, removes solvent, obtains raw material medicated powder, incapsulate.

Usage and consumption: every day three times, one time four, warm water delivery service one week is a course for the treatment of.

Model case: Zhang, 66 years old, is diagnosed as poor sleeping quality, poor appetite, fatigue and weak, and oral Chinese medicine preparation of the present invention 20 days symptoms are obviously improved, after consolidated again one month, rehabilitation, does not recur so far.

Pharmacological toxicity is tested

1, acute toxicity test

Application mice carries out acute toxicity testing and shows: Mouse oral gavage Chinese medicine preparation of the present invention, under 488.8g crude drug/kg dosage, after administration, mice occurs that light activity reduces, 1 hours recovers normal, Continuous Observation 7 days after administration, none animal dead, its overall health of patients, diet, take the photograph water, urine and body weight increase all normal, experimental result shows: the maximum dosage-feeding of Mouse oral gavage Traditional Chinese medicine preparation capsule agent of the present invention is 488.8g crude drug/kg/d (LD 50 > 488.8g crude drug/kg).Chinese medicine preparation clinical application every day total amount of the present invention is 0.1g crude drug/kg/d; By weighing machine, the dosis tolerata of mouse stomach Chinese medicine preparation of the present invention is 4888 times of clinical patient.Point out this medicine acute toxicity low, clinical drug safety.

2, long term toxicity test

Select SD rat, give the Chinese medicine preparation of the present invention of variable concentrations (18.0,6.0,2.0g crude drug/kg), every day gavage once, continuous 90 days, within after last administration 24 hours, respectively group is alive kills 1/2 animal (male and female half and half), and all the other 1/2 animals continue observations 2 weeks rear living and kill.Duration of test observes outward appearance, general behavior, food ration, the body weight change of animal, within after administration 90 days, within 2 weeks, carries out the index checking such as hematology's (RBC, HB, reticulocyte, PLT, CT, WBC and classification) and blood biochemical (AST, ALT, ALP, Glu, BUN, Crea, TP, T.BIL, ALB, CHOL), urine biochemistry, organ coefficient, histopathology with drug withdrawal.Result of the test shows: invention formulation is good at high, medium and low dosage treated animal general state, and outward appearance sign, behavioral activity, food-intake and body weight increase change all without exception; Three dosage groups and matched group hematological examination, blood biochemical analysis, urine biochemical analysis all in normal range, without significant difference between group; Each group of main organs histopathological examination shows no obvious abnormalities.These parameters drug withdrawal also had no change after 2 weeks.This test dosage is respectively 180,60,20 times of clinical medicine dose, rat is had no significant effect in high, medium and low three dosage (18.0,6.0,2.0g crude drug/kg) administration in continuous 90 days according to result of the test Chinese medicine preparation of the present invention, without clear and definite toxicity target organ and sensitive indicator, convalescent period observation also has no retardance toxic reaction, points out the dose safety of Chinese medicine preparation clinical practice of the present invention higher.

3, animal local excitation test:

The allergic reaction on guinea pigs of invention formulation and capsule Rat-rectum medication irritation test.Result shows: skin anaphylactic test, high dose group 0.8g (medicated powder)/kg, low dose group 0.1g (medicated powder)/kg, be equivalent to 20 times, 2.5 times that intend clinical people's consumption [0.04g (medicated powder)/kg] respectively, through percutaneous drug delivery, be showed no animal and produce allergy; Rectal application irritation test high dose group 5.0g (medicated powder)/kg, low dose group 3.2g (medicated powder)/kg, be equivalent to 125,80 times that intend clinical people's consumption respectively, mucous membrane of rectum is observed all without phenomenons such as hyperemia, edema in official hour, histopathologic examination compares no significant difference with blank group, have no and occur obvious irritative response, often organize its overall health of patients of Some Animals of retention, body weight, breathing, circulation, central nervous system and extremity are movable, equal Non Apparent Abnormality reaction.

Clinical data

1 object and method

1.1 subject patient 200 examples, are divided into matched group 5O example at random, man 35 example, female 15 example, treatment group 150 example, man 90 example, female 60 example, two groups of ages all 18-80 year between.

1.2 diagnostic criterias are with reference to clinical manifestation:

Have a delicate constitution, malnutrition, lethargy, fatigue and weak, appetite reduce, sleep disorder.

1.3 Therapeutic Method treatment groups: take capsule of the present invention, natural gift three times are taken, 4 tablets/time, seven days courses for the treatment of.

Matched group: transfusion: liquid of glucose, oral multi-vitamin;

1.4 efficacy assessment standards (1) clinical recovery: clinical symptoms, sign disappear, functional activity recovers normal, checks that indices recovers.

(2) effective: symptom obviously alleviates.(3) effective: symptom alleviates slightly.(4) invalid: clinical symptoms, sign are without change.

I.5 statistical procedures uses SPSS 12.0 software to carry out statistical analysis, and ask that mean compares employing one factor analysis of variance for each group, group is asked and compared employing between two.Inspection.P<0.05 is that difference has significance.

2 results

Matched group recovery from illness 22 example, accounts for 44%; Effective 11 examples, account for 22%; Effective 8 examples, account for 16%; No effect 9, accounts for 18%, total effective rate 82%.Treatment group recovery from illness 98 example, accounts for 65.33%; Effective 32 examples, account for 21.33%; Effective 15 examples, account for 10%; Invalid 5 examples, account for 3.33%.Total effective rate accounts for 96.66%.Significance (P<O.05) is had through checking two groups of differences.

All above-mentioned this intellectual properties of primary enforcement, not setting restriction this new product of other forms of enforcement and/or new method.Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar implementation status.But all modifications or transformation belong to the right of reservation based on new product of the present invention.

The above is only preferred embodiment of the present invention, and be not restriction the present invention being made to other form, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the Equivalent embodiments of equivalent variations.But everyly do not depart from technical solution of the present invention content, any simple modification, equivalent variations and the remodeling done above embodiment according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.

Claims (4)

1. one kind is improved the Chinese medicine preparation of immunity, it is characterized in that, in described Chinese medicine preparation, the ratio of weight and number of various crude drug is: Flos Spatholirionis longifolii 5-10 part, Fructus Akebiae 5-10 part, Herba Cistanches 5-10 part, Plumula Nelumbinis 5-10 part, Arillus Longan 5-10 part, Radix Salviae Miltiorrhizae 5-10 part, Rhizoma Cyperi 5-10 part, Olibanum 5-10 part, Fructus Crataegi 5-10 part, Radix Glycyrrhizae Preparata 5-10 part, Semen Platycladi 5-10 part, Aloe 5-10 part, Flos Ginseng 5-10 part, Radix Ginseng Rubra 5-10 part, Cordyceps 5-10 part.

2. a kind of Chinese medicine preparation improving immunity according to claim 1, it is characterized in that, in described Chinese medicine preparation, the ratio of weight and number of various crude drug is: Flos Spatholirionis longifolii 6-8 part, Fructus Akebiae 6-8 part, Herba Cistanches 6-8 part, Plumula Nelumbinis 6-8 part, Arillus Longan 6-8 part, Radix Salviae Miltiorrhizae 6-8 part, Rhizoma Cyperi 6-8 part, Olibanum 6-8 part, Fructus Crataegi 6-8 part, Radix Glycyrrhizae Preparata 6-8 part, Semen Platycladi 6-8 part, Aloe 6-8 part, Flos Ginseng 6-8 part, Radix Ginseng Rubra 6-8 part, Cordyceps 6-8 part.

3. a kind of Chinese medicine preparation improving immunity according to claim 1, it is characterized in that, in described Chinese medicine preparation, the ratio of weight and number of various crude drug is: Flos Spatholirionis longifolii 7 parts, Fructus Akebiae 7 parts, Herba Cistanches 7 parts, Plumula Nelumbinis 7 parts, Arillus Longan 7 parts, Radix Salviae Miltiorrhizae 7 parts, Rhizoma Cyperi 7 parts, Olibanum 7 parts, Fructus Crataegi 7 parts, Radix Glycyrrhizae Preparata 7 parts, Semen Platycladi 7 parts, Aloe 7 parts, Flos Ginseng 7 parts, Radix Ginseng Rubra 7 parts, Cordyceps 7 parts.

4. a kind of preparation method improving the Chinese medicine preparation of immunity according to claim 1-3 any one, is characterized in that: described Chinese medicine preparation dosage form is that the preparation method of capsule comprises:

Step a, puts into 10 times of water gagings by formula proportion by crude drug, heating and refluxing extraction 3 times, each 45 minutes ~ 1 hour, is merged by 3 extracting solution and leaves standstill;

Step b, by above-mentioned decompression filtrate recycling ethanol and to be concentrated into liquor strength be 0.4g crude drug/mL, after sucking filtration, when the relative density of filtrate is about 20 DEG C 1.06; Above-mentioned filtrate is the macroporous adsorptive resins of 10L through volume, first uses deionized water or the distilled water eluting of 10 times of resin column volumes, then uses 95% ethanol elution of 5 times of resin column volumes, collects ethanol elution, removes solvent, obtains raw material medicated powder, incapsulate.