Nothing Special   »   [go: up one dir, main page]

CL2023001556A1 - Proteínas de unión a il-7 y su uso en tratamientos médicos - Google Patents

Proteínas de unión a il-7 y su uso en tratamientos médicos

Info

Publication number
CL2023001556A1
CL2023001556A1 CL2023001556A CL2023001556A CL2023001556A1 CL 2023001556 A1 CL2023001556 A1 CL 2023001556A1 CL 2023001556 A CL2023001556 A CL 2023001556A CL 2023001556 A CL2023001556 A CL 2023001556A CL 2023001556 A1 CL2023001556 A1 CL 2023001556A1
Authority
CL
Chile
Prior art keywords
binding proteins
medical treatments
treatments
medical
interleukin
Prior art date
Application number
CL2023001556A
Other languages
English (en)
Inventor
BOUMA Gerben
Thomas Coulstock Edward
Dixon David
hopley Stephanie
Peter Lewis Alan
Lynn NEISEN Jessica
Original Assignee
Glaxosmithkline Ip Dev Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxosmithkline Ip Dev Ltd filed Critical Glaxosmithkline Ip Dev Ltd
Publication of CL2023001556A1 publication Critical patent/CL2023001556A1/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244Interleukins [IL]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75Agonist effect on antigen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

En el presente documento se proporcionan proteínas de unión a interleucina 7 (IL-7), composiciones farmacéuticas y su uso en el tratamiento o prevención de una enfermedad o afección.
CL2023001556A 2020-12-02 2023-05-31 Proteínas de unión a il-7 y su uso en tratamientos médicos CL2023001556A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US202063120564P 2020-12-02 2020-12-02

Publications (1)

Publication Number Publication Date
CL2023001556A1 true CL2023001556A1 (es) 2023-11-10

Family

ID=78844686

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2023001556A CL2023001556A1 (es) 2020-12-02 2023-05-31 Proteínas de unión a il-7 y su uso en tratamientos médicos

Country Status (14)

Country Link
US (2) US11802150B2 (es)
EP (1) EP4255928A1 (es)
JP (1) JP2023551935A (es)
KR (1) KR20230098288A (es)
CN (1) CN116547002A (es)
AR (1) AR124286A1 (es)
AU (1) AU2021391493A1 (es)
CA (1) CA3199648A1 (es)
CL (1) CL2023001556A1 (es)
CO (1) CO2023007851A2 (es)
IL (1) IL303134A (es)
MX (1) MX2023006294A (es)
TW (1) TWI821804B (es)
WO (1) WO2022117526A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR129445A1 (es) * 2022-05-27 2024-08-28 Glaxosmithkline Ip Dev Ltd USO DE PROTEÍNAS DE UNIÓN A TNF-a Y PROTEÍNAS DE UNIÓN A IL-7 EN EL TRATAMIENTO MÉDICO

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57106673A (en) 1980-12-24 1982-07-02 Chugai Pharmaceut Co Ltd Dibenzo(b,f)(1,4)oxazepin derivative
GB8607679D0 (en) 1986-03-27 1986-04-30 Winter G P Recombinant dna product
JP3101690B2 (ja) 1987-03-18 2000-10-23 エス・ビィ・2・インコーポレイテッド 変性抗体の、または変性抗体に関する改良
IL127127A0 (en) 1998-11-18 1999-09-22 Peptor Ltd Small functional units of antibody heavy chain variable regions
US6737056B1 (en) 1999-01-15 2004-05-18 Genentech, Inc. Polypeptide variants with altered effector function
US7504256B1 (en) 1999-10-19 2009-03-17 Kyowa Hakko Kogyo Co., Ltd. Process for producing polypeptide
US20050053973A1 (en) 2001-04-26 2005-03-10 Avidia Research Institute Novel proteins with targeted binding
US20050089932A1 (en) 2001-04-26 2005-04-28 Avidia Research Institute Novel proteins with targeted binding
EP2180044A1 (en) 2001-08-03 2010-04-28 GlycArt Biotechnology AG Antibody glycosylation variants having increased anti-body-dependent cellular cytotoxicity
CA2499816C (en) 2002-09-27 2013-07-30 Xencor, Inc. Optimized fc variants and methods for their generation
US7355008B2 (en) 2003-01-09 2008-04-08 Macrogenics, Inc. Identification and engineering of antibodies with variant Fc regions and methods of using same
CA2543360A1 (en) 2003-10-24 2005-05-06 Joost A. Kolkman Ldl receptor class a and egf domain monomers and multimers
JP2008512353A (ja) 2004-07-21 2008-04-24 グライコフィ, インコーポレイテッド 主にGlcNAc2Man3GlcNAc2グリコフォームを含むイムノグロブリン
TW201018482A (en) 2008-08-08 2010-05-16 Glaxo Wellcome Mfg Pte Ltd Novel treatment
PT2506871T (pt) 2009-11-30 2016-11-07 Janssen Biotech Inc Mutantes de fc de anticorpos com funções efetoras inutilizadas

Also Published As

Publication number Publication date
CO2023007851A2 (es) 2023-06-30
AU2021391493A1 (en) 2023-06-08
AR124286A1 (es) 2023-03-15
JP2023551935A (ja) 2023-12-13
US11802150B2 (en) 2023-10-31
US20240025988A1 (en) 2024-01-25
KR20230098288A (ko) 2023-07-03
MX2023006294A (es) 2023-06-13
AU2021391493A9 (en) 2024-05-23
WO2022117526A1 (en) 2022-06-09
IL303134A (en) 2023-07-01
TW202237183A (zh) 2022-10-01
CN116547002A (zh) 2023-08-04
US12122828B2 (en) 2024-10-22
CA3199648A1 (en) 2022-06-09
US20220169717A1 (en) 2022-06-02
TWI821804B (zh) 2023-11-11
EP4255928A1 (en) 2023-10-11

Similar Documents

Publication Publication Date Title
CO2020009625A2 (es) Inhibidor de fap
CY1118519T1 (el) Συνθεση τετρακυκλινων και αναλογων αυτων
CY1118006T1 (el) Χρηση γαλακτοβακιλλων για την αγωγη ιικων λοιμωξεων
CY1126152T1 (el) Ενωσεις-αναστολεις της rip1 και μεθοδοι παρασκευης και χρησης αυτων
CY1107467T1 (el) Χρηση οξεογονων υδρογονοτροφων στελεχων για την προληψη ή την αγωγη πεπτικων διαταραχων
CY1125104T1 (el) Συνθεσεις φλαγελλινης entrecoccus για χρηση στη θεραπεια
MX2020008208A (es) Agentes de unión a fibroblastos y uso de estos.
CA3155883A1 (en) BUCCO-DENTAL CARE COMPOSITIONS BASED ON BETA ACID OF HOPS AND AMINO ACID
WO2022167816A3 (en) Antibodies
MX2023003677A (es) Inhibidores de hidroxiesteroide 17beta- deshidrogenasa 13 (hsd17b13) y usos de estos.
ECSP066805A (es) Compuestos silinano como inhibidores de cisteína proteasa
AR122380A1 (es) Uso de inhibidores de sglt-2 para la prevención y/o tratamiento de enfermedades cardíacas en felinos
MX2023003678A (es) Inhibidores de hidroxiesteroide 17beta- deshidrogenasa 13 (hsd17b13) y usos de estos.
BR112021015751A2 (pt) Vetores de terapia genética para tratamento da doença de danon
AU2018326364A1 (en) Methods of enhancing and/or stabilizing cardiac function in patients with Fabry disease
MX2022005547A (es) Derivados terapeuticos de interleucina-22.
CO2023013050A2 (es) Composiciones de psilocibina, métodos para prepararlas y métodos de uso de estas
CL2021000924A1 (es) Uso de reboxetina para el tratamiento de narcolepsia
CO2023007851A2 (es) Proteínas de unión a il-7 y su uso en tratamientos médicos
CR20220374A (es) Métodos de tratamiento de la esplenomegalia
MX2023009971A (es) Composicion farmaceutica que contiene anticuerpo anti-tslp.
ECSP045397A (es) 6-ALQUILIDEN-PENEMS BICÍCLICOS COMO INHIBIDORES DE LAS b-LACTAMASAS
WO2021004958A3 (en) Compositions comprising bacterial strains
EA202091112A1 (ru) Сокристаллы, фармацевтические композиции на их основе и способы лечения, предусматривающие их применение
BR112023000229A2 (pt) Composto, composição farmacêutica, e, peptídeo