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CL2019000703A1 - Compuestos y métodos para la reducción de la expresión de tau. - Google Patents

Compuestos y métodos para la reducción de la expresión de tau.

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Publication number
CL2019000703A1
CL2019000703A1 CL2019000703A CL2019000703A CL2019000703A1 CL 2019000703 A1 CL2019000703 A1 CL 2019000703A1 CL 2019000703 A CL2019000703 A CL 2019000703A CL 2019000703 A CL2019000703 A CL 2019000703A CL 2019000703 A1 CL2019000703 A1 CL 2019000703A1
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CL
Chile
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methods
compounds
amount
animal
cell
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CL2019000703A
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English (en)
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Holly Kordasiewicz
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Ionis Pharmaceuticals Inc
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Publication of CL2019000703A1 publication Critical patent/CL2019000703A1/es

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Abstract

SE PROPORCIONAN COMPUESTOS, MÉTODOS Y COMPOSICIONES FARMACÉUTICAS PARA REDUCIR LA CANTIDAD O LA ACTIVIDAD DEL ARNM DE TAU EN UNA CÉLULA O ANIMAL, Y EN DETERMINADOS CASOS PARA REDUCIR LA CANTIDAD DE PROTEÍNA TAU EN UNA CÉLULA O ANIMAL. TALES COMPUESTOS, MÉTODOS Y COMPOSICIONES FARMACÉUTICAS SON ÚTILES PARA MEJORAR AL MENOS UN SÍNTOMA DE UNA ENFERMEDAD NEURODEGENERATIVA. DICHOS SÍNTOMAS INCLUYEN PÉRDIDA DE MEMORIA, PÉRDIDA DE LA FUNCIÓN MOTORA Y AUMENTO EN LA CANTIDAD Y/O EL VOLUMEN DE LAS INCLUSIONES NEUROFIBRILARES. DICHAS ENFERMEDADES NEURODEGENERATIVOS INCLUYEN TAUPATÍAS, ENFERMEDAD DE ALZHEIMER, DEMENCIA FRONTOTEMPORAL (FTD), FTDP-17, PARÁLISIS SUPRANUCLEAR PROGRESIVA (PSP), ENCEFALOPATÍA TRAUMÁTICA CRÓNICA (CTE), DEGENERACIÓN GANGLIÓNICA CORTICOBASAL (CBD), EPILEPSIA Y SÍNDROME DE DRAVET.
CL2019000703A 2016-09-29 2019-03-18 Compuestos y métodos para la reducción de la expresión de tau. CL2019000703A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662401723P 2016-09-29 2016-09-29
US201762450469P 2017-01-25 2017-01-25

Publications (1)

Publication Number Publication Date
CL2019000703A1 true CL2019000703A1 (es) 2019-08-09

Family

ID=61760152

Family Applications (2)

Application Number Title Priority Date Filing Date
CL2019000703A CL2019000703A1 (es) 2016-09-29 2019-03-18 Compuestos y métodos para la reducción de la expresión de tau.
CL2020000183A CL2020000183A1 (es) 2016-09-29 2020-01-21 Compuestos y métodos para la reducción de la expresión de tau. (divisional solicitud 201900703)

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CL2020000183A CL2020000183A1 (es) 2016-09-29 2020-01-21 Compuestos y métodos para la reducción de la expresión de tau. (divisional solicitud 201900703)

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US (3) US10407680B2 (es)
EP (2) EP3519572B1 (es)
JP (4) JP6738004B2 (es)
KR (2) KR102286223B1 (es)
CN (2) CN109790543B (es)
AU (3) AU2017336093B2 (es)
BR (2) BR112019003162B1 (es)
CA (1) CA3038891A1 (es)
CL (2) CL2019000703A1 (es)
CO (1) CO2019001385A2 (es)
CR (2) CR20190214A (es)
DK (1) DK3519572T5 (es)
ES (1) ES2963428T3 (es)
FI (1) FI3519572T3 (es)
HR (1) HRP20231606T1 (es)
HU (1) HUE065170T2 (es)
IL (3) IL299615A (es)
JO (1) JOP20190065A1 (es)
LT (1) LT3519572T (es)
MD (1) MD3519572T2 (es)
MX (2) MX2019003633A (es)
NZ (1) NZ750642A (es)
PE (1) PE20190655A1 (es)
PL (1) PL3519572T3 (es)
PT (1) PT3519572T (es)
RS (1) RS64941B1 (es)
SG (1) SG11201901140QA (es)
SI (1) SI3519572T1 (es)
WO (1) WO2018064593A1 (es)
ZA (2) ZA201900920B (es)

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CN105264091B (zh) 2013-03-14 2020-02-28 Ionis制药公司 用于调节tau表达的组合物和方法
TWI772856B (zh) 2013-07-19 2022-08-01 美商百健Ｍａ公司 用於調節τ蛋白表現之組合物
JOP20190065A1 (ar) * 2016-09-29 2019-03-28 Ionis Pharmaceuticals Inc مركبات وطرق لتقليل التعبير عن tau
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KR102585973B1 (ko) 2018-07-03 2023-10-10 에프. 호프만-라 로슈 아게 타우 발현을 조절하기 위한 올리고뉴클레오티드
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EP4312977A1 (en) 2021-04-01 2024-02-07 Biogen MA Inc. Nucleic acid delivery to the central nervous system
TW202317765A (zh) 2021-06-18 2023-05-01 美商Ionis製藥公司 用於降低ｉｆｎａｒ１表現的化合物及方法
WO2023004426A2 (en) * 2021-07-23 2023-01-26 University Of Kentucky Research Foundation Inhibition of neurofibrillary tangles using oligonucleotides against circular rnas from the microtubule associated protein tau (mapt) locus
TW202310854A (zh) * 2021-07-23 2023-03-16 美商百健Ｍａ公司 用於減少ｔａｕ表現之方法

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