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CL2018002703A1 - Agentes de iarn, composiciones y métodos de uso de los mismos para tratar enfermedades asociadas con transtiretina (ttr). (divisional solicitud 201401291) - Google Patents

Agentes de iarn, composiciones y métodos de uso de los mismos para tratar enfermedades asociadas con transtiretina (ttr). (divisional solicitud 201401291)

Info

Publication number
CL2018002703A1
CL2018002703A1 CL2018002703A CL2018002703A CL2018002703A1 CL 2018002703 A1 CL2018002703 A1 CL 2018002703A1 CL 2018002703 A CL2018002703 A CL 2018002703A CL 2018002703 A CL2018002703 A CL 2018002703A CL 2018002703 A1 CL2018002703 A1 CL 2018002703A1
Authority
CL
Chile
Prior art keywords
iarn
agents
ttr
methods
transthyretin
Prior art date
Application number
CL2018002703A
Other languages
English (en)
Inventor
Klaus Charisse
Martin Maier
Tracy Zimmermann
Kallanthottathil G Rajeev
Muthiah Manoharan
Satyanarayana Kuchimanchi
Original Assignee
Alnylam Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48430225&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2018002703(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Alnylam Pharmaceuticals Inc filed Critical Alnylam Pharmaceuticals Inc
Publication of CL2018002703A1 publication Critical patent/CL2018002703A1/es

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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07—ORGANIC CHEMISTRY
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    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
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    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1136—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
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    • C12N2310/00—Structure or type of the nucleic acid
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Abstract

LA PRESENTE INVENCIÓN PROPORCIONA AGENTES DE IARN, POR EJEMPLO, AGENTES DE IARN DE DOBLE HEBRA, QUE SE DIRIGEN AL GEN DE LA TRANSTIRETINA (TTR) Y MÉTODOS PARA UTILIZAR DICHOS AGENTES DE IARN PARA TRATAR O PREVENIR ENFERMEDADES ASOCIADAS A TTR.
CL2018002703A 2011-11-18 2018-09-24 Agentes de iarn, composiciones y métodos de uso de los mismos para tratar enfermedades asociadas con transtiretina (ttr). (divisional solicitud 201401291) CL2018002703A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161561710P 2011-11-18 2011-11-18
US201261615618P 2012-03-26 2012-03-26
US201261680098P 2012-08-06 2012-08-06

Publications (1)

Publication Number Publication Date
CL2018002703A1 true CL2018002703A1 (es) 2018-12-28

Family

ID=48430225

Family Applications (3)

Application Number Title Priority Date Filing Date
CL2014001291A CL2014001291A1 (es) 2011-11-18 2014-05-15 Agentes de iarn de doble hebra; composiciones y metodos de uso de los mismos para tratar enfermedades asociadas con transtiretina (ttr).
CL2014002742A CL2014002742A1 (es) 2011-11-18 2014-10-10 Agentes de iarn, composiciones y métodos de uso de los mismos para tratar enfermedades asociadas con transtiretina (ttr) (divisional de solicitud 1291-2014)
CL2018002703A CL2018002703A1 (es) 2011-11-18 2018-09-24 Agentes de iarn, composiciones y métodos de uso de los mismos para tratar enfermedades asociadas con transtiretina (ttr). (divisional solicitud 201401291)

Family Applications Before (2)

Application Number Title Priority Date Filing Date
CL2014001291A CL2014001291A1 (es) 2011-11-18 2014-05-15 Agentes de iarn de doble hebra; composiciones y metodos de uso de los mismos para tratar enfermedades asociadas con transtiretina (ttr).
CL2014002742A CL2014002742A1 (es) 2011-11-18 2014-10-10 Agentes de iarn, composiciones y métodos de uso de los mismos para tratar enfermedades asociadas con transtiretina (ttr) (divisional de solicitud 1291-2014)

Country Status (37)

Country Link
US (5) US9399775B2 (es)
EP (4) EP3913056A1 (es)
JP (4) JP6165158B2 (es)
KR (4) KR102385013B1 (es)
CN (2) CN108186667B (es)
AR (1) AR088911A1 (es)
AU (4) AU2012340159B2 (es)
BR (1) BR112014011896B1 (es)
CA (1) CA2856243A1 (es)
CL (3) CL2014001291A1 (es)
CO (1) CO7020872A2 (es)
CR (1) CR20140232A (es)
CY (1) CY1123693T1 (es)
DK (1) DK3301177T3 (es)
DO (1) DOP2014000107A (es)
EC (1) ECSP14005606A (es)
ES (1) ES2800065T3 (es)
GT (1) GT201400097A (es)
HK (2) HK1200171A1 (es)
HR (1) HRP20200672T1 (es)
HU (1) HUE048622T2 (es)
IL (6) IL293434B2 (es)
IN (1) IN2014CN03463A (es)
LT (1) LT3301177T (es)
MX (2) MX348575B (es)
MY (1) MY167390A (es)
NI (1) NI201400046A (es)
PE (1) PE20142362A1 (es)
PH (1) PH12014501106A1 (es)
PL (1) PL3301177T3 (es)
PT (1) PT3301177T (es)
RS (1) RS60414B1 (es)
RU (1) RU2678807C2 (es)
SG (2) SG11201402392QA (es)
SI (1) SI3301177T1 (es)
UA (1) UA118649C2 (es)
WO (1) WO2013075035A1 (es)

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