CL2009000116A1 - Compuestos derivados de heterotriciclos sustituidos, antagonistas del receptor crf; sus composiciones farmaceuticas; y uso de dichos compuestos para el tratamiento de trastornos afectivos, depresion, ansiedad y sindrome del colon irritable. - Google Patents
Compuestos derivados de heterotriciclos sustituidos, antagonistas del receptor crf; sus composiciones farmaceuticas; y uso de dichos compuestos para el tratamiento de trastornos afectivos, depresion, ansiedad y sindrome del colon irritable.Info
- Publication number
- CL2009000116A1 CL2009000116A1 CL2009000116A CL2009000116A CL2009000116A1 CL 2009000116 A1 CL2009000116 A1 CL 2009000116A1 CL 2009000116 A CL2009000116 A CL 2009000116A CL 2009000116 A CL2009000116 A CL 2009000116A CL 2009000116 A1 CL2009000116 A1 CL 2009000116A1
- Authority
- CL
- Chile
- Prior art keywords
- compounds
- heterotricycles
- anxiety
- depression
- substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Compuestos derivados de heterotriciclos sustituidos, moduladores del receptor crf; útiles en el tratamiento de los trastornos afectivos, depresión y ansiedad.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US655408P | 2008-01-22 | 2008-01-22 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2009000116A1 true CL2009000116A1 (es) | 2010-08-27 |
Family
ID=40637104
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2009000116A CL2009000116A1 (es) | 2008-01-22 | 2009-01-21 | Compuestos derivados de heterotriciclos sustituidos, antagonistas del receptor crf; sus composiciones farmaceuticas; y uso de dichos compuestos para el tratamiento de trastornos afectivos, depresion, ansiedad y sindrome del colon irritable. |
Country Status (26)
Country | Link |
---|---|
US (2) | US8901141B2 (es) |
EP (1) | EP2240485B1 (es) |
JP (1) | JP5431341B2 (es) |
KR (1) | KR20100130596A (es) |
CN (1) | CN101981031A (es) |
AR (1) | AR070218A1 (es) |
AU (1) | AU2009206936A1 (es) |
BR (1) | BRPI0907230A2 (es) |
CA (1) | CA2712347A1 (es) |
CL (1) | CL2009000116A1 (es) |
CO (1) | CO6230982A2 (es) |
CR (1) | CR11636A (es) |
DO (1) | DOP2010000226A (es) |
EA (1) | EA201070876A1 (es) |
EC (1) | ECSP10010414A (es) |
GE (1) | GEP20125637B (es) |
IL (1) | IL207074A0 (es) |
MA (1) | MA32438B1 (es) |
MX (1) | MX2010008039A (es) |
NZ (1) | NZ587215A (es) |
PE (1) | PE20091439A1 (es) |
SG (1) | SG189803A1 (es) |
TW (1) | TW200936591A (es) |
UY (1) | UY31604A1 (es) |
WO (1) | WO2009093747A1 (es) |
ZA (1) | ZA201005340B (es) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI370820B (en) * | 2005-04-27 | 2012-08-21 | Takeda Pharmaceutical | Fused heterocyclic compounds |
RU2011137419A (ru) | 2009-02-11 | 2013-03-20 | Суновион Фармасьютикалз Инк. | Обратные агонисты и антагонисты гистамина н3 и способы их применения |
CN102686586A (zh) * | 2009-09-11 | 2012-09-19 | 桑诺维恩药品公司 | 组胺h3反相激动剂和拮抗剂及其使用方法 |
EP2746265B1 (en) | 2011-08-18 | 2015-11-18 | Nippon Shinyaku Co., Ltd. | HETEROCYCLIC DERIVATIVE AS MICROSOMAL PROSTAGLANDIN E SYNTHASE (mPGEs) INHIBITOR |
EP2825542B1 (en) | 2012-03-16 | 2016-09-14 | Vitae Pharmaceuticals, Inc. | Liver x receptor modulators |
DK2825541T3 (en) | 2012-03-16 | 2016-10-03 | Vitae Pharmaceuticals Inc | LIVER-X-receptor modulators |
US10005720B2 (en) | 2013-04-05 | 2018-06-26 | North Carolina Central University | Compounds useful for the treatment of metabolic disorders and synthesis of the same |
CN103435618B (zh) * | 2013-08-22 | 2016-03-23 | 中国药科大学 | 一种合成稠杂环化合物的方法 |
JP6580074B2 (ja) * | 2014-05-23 | 2019-09-25 | アクティブ バイオテック エイビー | S100阻害薬として有用な新規化合物 |
CN105859630B (zh) * | 2015-01-22 | 2019-01-18 | 北京大学 | 一种咪唑酮衍生物的合成方法及应用 |
EP3150604B1 (en) | 2015-10-01 | 2021-07-14 | Idemitsu Kosan Co., Ltd. | Benzimidazolo[1,2-a]benzimidazole carrying benzimidazolo[1,2-a]benzimidazolylyl groups, carbazolyl groups, benzofurane groups or benzothiophene groups for organic light emitting diodes |
WO2017056055A1 (en) | 2015-10-01 | 2017-04-06 | Idemitsu Kosan Co., Ltd. | Benzimidazolo[1,2-a]benzimidazole carrying triazine groups for organic light emitting diodes |
WO2018220513A1 (en) * | 2017-05-31 | 2018-12-06 | Alembic Pharmaceuticals Limited | An improved process for preparation of obeticholic acid |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS516993A (en) | 1974-07-05 | 1976-01-20 | Dainippon Pharmaceutical Co | Adeninjudotaino seiho |
ES2294047T3 (es) * | 2000-12-28 | 2008-04-01 | Ono Pharmaceutical Co., Ltd. | Un compuesto de ciclopenta (d) pirazolo(1,5-a) pirimidina como antagonista del receptor de crf. |
GB0308208D0 (en) * | 2003-04-09 | 2003-05-14 | Glaxo Group Ltd | Chemical compounds |
US7872133B2 (en) * | 2003-06-23 | 2011-01-18 | Ono Pharmaceutical Co., Ltd. | Tricyclic heterocycle compound |
EP2522670A1 (en) * | 2004-04-07 | 2012-11-14 | Takeda Pharmaceutical Company Limited | Heterocyclic CRF receptor antagonists |
TWI370820B (en) * | 2005-04-27 | 2012-08-21 | Takeda Pharmaceutical | Fused heterocyclic compounds |
JP2010507664A (ja) | 2006-10-25 | 2010-03-11 | 武田薬品工業株式会社 | ベンズイミダゾール化合物 |
US8039500B2 (en) | 2006-12-29 | 2011-10-18 | Takeda Pharmaceutical Company Limited | Fused heterocyclic compounds |
CA2711713A1 (en) * | 2008-01-22 | 2009-07-30 | Boehringer Ingelheim International Gmbh | Substituted amino-benzimidazoles, medicaments comprising said compound, their use and their method of manufacture |
FR2926556B1 (fr) * | 2008-01-22 | 2010-02-19 | Sanofi Aventis | Derives de carboxamides n-azabicycliques, leur preparation et leur application en therapeutique |
FR2926554B1 (fr) * | 2008-01-22 | 2010-03-12 | Sanofi Aventis | Derives de carboxamides azabicycliques, leur preparation et leur application en therapeutique |
JO2797B1 (en) * | 2008-01-22 | 2014-03-15 | ايلي ليلي اند كومباني | Selective opioid receptor antagonist kappa |
-
2009
- 2009-01-21 EA EA201070876A patent/EA201070876A1/ru unknown
- 2009-01-21 CA CA2712347A patent/CA2712347A1/en not_active Abandoned
- 2009-01-21 CN CN2009801105455A patent/CN101981031A/zh active Pending
- 2009-01-21 TW TW098102200A patent/TW200936591A/zh unknown
- 2009-01-21 AU AU2009206936A patent/AU2009206936A1/en not_active Abandoned
- 2009-01-21 UY UY031604A patent/UY31604A1/es not_active Application Discontinuation
- 2009-01-21 GE GEAP200911925A patent/GEP20125637B/en unknown
- 2009-01-21 US US12/863,851 patent/US8901141B2/en not_active Expired - Fee Related
- 2009-01-21 US US12/357,158 patent/US8785460B2/en not_active Expired - Fee Related
- 2009-01-21 NZ NZ587215A patent/NZ587215A/xx not_active IP Right Cessation
- 2009-01-21 EP EP09704168.5A patent/EP2240485B1/en active Active
- 2009-01-21 KR KR1020107018307A patent/KR20100130596A/ko not_active Application Discontinuation
- 2009-01-21 AR ARP090100180A patent/AR070218A1/es not_active Application Discontinuation
- 2009-01-21 PE PE2009000069A patent/PE20091439A1/es not_active Application Discontinuation
- 2009-01-21 JP JP2010528624A patent/JP5431341B2/ja not_active Expired - Fee Related
- 2009-01-21 MX MX2010008039A patent/MX2010008039A/es not_active Application Discontinuation
- 2009-01-21 SG SG2013029723A patent/SG189803A1/en unknown
- 2009-01-21 BR BRPI0907230A patent/BRPI0907230A2/pt not_active IP Right Cessation
- 2009-01-21 CL CL2009000116A patent/CL2009000116A1/es unknown
- 2009-01-21 WO PCT/JP2009/051299 patent/WO2009093747A1/en active Application Filing
-
2010
- 2010-07-18 IL IL207074A patent/IL207074A0/en unknown
- 2010-07-21 DO DO2010000226A patent/DOP2010000226A/es unknown
- 2010-07-27 ZA ZA2010/05340A patent/ZA201005340B/en unknown
- 2010-08-13 MA MA33084A patent/MA32438B1/fr unknown
- 2010-08-18 CR CR11636A patent/CR11636A/es not_active Application Discontinuation
- 2010-08-20 CO CO10102942A patent/CO6230982A2/es active IP Right Grant
- 2010-08-20 EC EC2010010414A patent/ECSP10010414A/es unknown
Also Published As
Publication number | Publication date |
---|---|
CA2712347A1 (en) | 2009-07-30 |
US20100298287A1 (en) | 2010-11-25 |
IL207074A0 (en) | 2010-12-30 |
SG189803A1 (en) | 2013-05-31 |
MX2010008039A (es) | 2010-08-10 |
AR070218A1 (es) | 2010-03-25 |
JP5431341B2 (ja) | 2014-03-05 |
US8785460B2 (en) | 2014-07-22 |
DOP2010000226A (es) | 2010-10-15 |
ZA201005340B (en) | 2011-10-26 |
UY31604A1 (es) | 2009-08-31 |
EP2240485A1 (en) | 2010-10-20 |
TW200936591A (en) | 2009-09-01 |
WO2009093747A1 (en) | 2009-07-30 |
US20090186879A1 (en) | 2009-07-23 |
ECSP10010414A (es) | 2010-09-30 |
AU2009206936A1 (en) | 2009-07-30 |
CO6230982A2 (es) | 2010-12-20 |
KR20100130596A (ko) | 2010-12-13 |
EP2240485B1 (en) | 2014-10-15 |
BRPI0907230A2 (pt) | 2019-09-24 |
PE20091439A1 (es) | 2009-10-19 |
JP2011509923A (ja) | 2011-03-31 |
CN101981031A (zh) | 2011-02-23 |
EA201070876A1 (ru) | 2011-04-29 |
MA32438B1 (fr) | 2011-07-03 |
GEP20125637B (en) | 2012-09-10 |
US8901141B2 (en) | 2014-12-02 |
NZ587215A (en) | 2012-08-31 |
CR11636A (es) | 2010-11-04 |
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