AR070218A1 - COMPUESTOS TRICíCLICOS, SUS PROFÁRMACOS, UNA COMPOSICIoN FARMACÉUTICA QUE LOS COMPRENDE Y SU USO EN LA PRODUCCIoN DE UN MEDICAMENTO PARA EL TRATAMIENTO DE ENFERMEDADES MEDIADAS POR EL RECEPTOR CRF. - Google Patents
COMPUESTOS TRICíCLICOS, SUS PROFÁRMACOS, UNA COMPOSICIoN FARMACÉUTICA QUE LOS COMPRENDE Y SU USO EN LA PRODUCCIoN DE UN MEDICAMENTO PARA EL TRATAMIENTO DE ENFERMEDADES MEDIADAS POR EL RECEPTOR CRF.Info
- Publication number
- AR070218A1 AR070218A1 ARP090100180A ARP090100180A AR070218A1 AR 070218 A1 AR070218 A1 AR 070218A1 AR P090100180 A ARP090100180 A AR P090100180A AR P090100180 A ARP090100180 A AR P090100180A AR 070218 A1 AR070218 A1 AR 070218A1
- Authority
- AR
- Argentina
- Prior art keywords
- optionally substituted
- crf
- nitrogen
- propharms
- mediationed
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Una de sus sales o uno de sus profármacos, que tienen actividad antagonista del receptor CRF y su uso en medicamentos y en composiciones farmacéuticas. Reivindicacion 1 Un compuesto caracterizado por la formula (1'): en donde X es un nitrogeno o CRx (en donde Rx es un hidrogeno o un alquilo C1-9, con la condicion de que, cuando X forma un enlace doble, Rx esté ausente); R1 es (1) un grupo hidrocarbonado opcionalmente sustituido, (2) un acilo, (3) un grupo heterocíclico opcionalmente sustituido, (4) un amino opcionalmente sustituido, (5) nitro, (6) un hidroxi opcionalmente sustituido, (7) un mercapto opcionalmente sustituido, (8) ciano, o (9) halogeno; R2 es (1) un grupo hidrocarbonado opcionalmente sustituido, (2) un acilo, (3) un grupo heterocíclico opcionalmente sustituido, o (4) un amino opcionalmente sustituido con la condicion de que se excluyan metilo, etilo, propilo y metoximetilo; el anillo A es un anillo heterocíclico de 5 a 8 miembros opcionalmente sustituido; y Y1, Y2, e Y3 son cada uno un carbono o un nitrogeno opcionalmente sustituido; excluyendo (i) un compuesto en donde Y1 e Y3 son cada uno un nitrogeno, R1 es amino y es un alquilo opcionalmente sustituido, (ii) 2,4,7-tricloro-9-(4-metilfenil)-6,7,8,9-tetrahidropirimido[2,1-f]purina, (iii) N-acetil-N-(8-acetil-7,8-dihidro-6H-imidazo [2,1-f]purin-4-il)acetamida, y (iv) un compuesto en donde R1 y R2 son cada uno, de modo simultáneo el grupo de formulas (2) o una de sus sales.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US655408P | 2008-01-22 | 2008-01-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR070218A1 true AR070218A1 (es) | 2010-03-25 |
Family
ID=40637104
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP090100180A AR070218A1 (es) | 2008-01-22 | 2009-01-21 | COMPUESTOS TRICíCLICOS, SUS PROFÁRMACOS, UNA COMPOSICIoN FARMACÉUTICA QUE LOS COMPRENDE Y SU USO EN LA PRODUCCIoN DE UN MEDICAMENTO PARA EL TRATAMIENTO DE ENFERMEDADES MEDIADAS POR EL RECEPTOR CRF. |
Country Status (26)
| Country | Link |
|---|---|
| US (2) | US8901141B2 (es) |
| EP (1) | EP2240485B1 (es) |
| JP (1) | JP5431341B2 (es) |
| KR (1) | KR20100130596A (es) |
| CN (1) | CN101981031A (es) |
| AR (1) | AR070218A1 (es) |
| AU (1) | AU2009206936A1 (es) |
| BR (1) | BRPI0907230A2 (es) |
| CA (1) | CA2712347A1 (es) |
| CL (1) | CL2009000116A1 (es) |
| CO (1) | CO6230982A2 (es) |
| CR (1) | CR11636A (es) |
| DO (1) | DOP2010000226A (es) |
| EA (1) | EA201070876A1 (es) |
| EC (1) | ECSP10010414A (es) |
| GE (1) | GEP20125637B (es) |
| IL (1) | IL207074A0 (es) |
| MA (1) | MA32438B1 (es) |
| MX (1) | MX2010008039A (es) |
| NZ (1) | NZ587215A (es) |
| PE (1) | PE20091439A1 (es) |
| SG (1) | SG189803A1 (es) |
| TW (1) | TW200936591A (es) |
| UY (1) | UY31604A1 (es) |
| WO (1) | WO2009093747A1 (es) |
| ZA (1) | ZA201005340B (es) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI370820B (en) * | 2005-04-27 | 2012-08-21 | Takeda Pharmaceutical | Fused heterocyclic compounds |
| RU2011137419A (ru) | 2009-02-11 | 2013-03-20 | Суновион Фармасьютикалз Инк. | Обратные агонисты и антагонисты гистамина н3 и способы их применения |
| CN102686586A (zh) * | 2009-09-11 | 2012-09-19 | 桑诺维恩药品公司 | 组胺h3反相激动剂和拮抗剂及其使用方法 |
| EP2746265B1 (en) | 2011-08-18 | 2015-11-18 | Nippon Shinyaku Co., Ltd. | HETEROCYCLIC DERIVATIVE AS MICROSOMAL PROSTAGLANDIN E SYNTHASE (mPGEs) INHIBITOR |
| EP2825542B1 (en) | 2012-03-16 | 2016-09-14 | Vitae Pharmaceuticals, Inc. | Liver x receptor modulators |
| DK2825541T3 (en) | 2012-03-16 | 2016-10-03 | Vitae Pharmaceuticals Inc | LIVER-X-receptor modulators |
| US10005720B2 (en) | 2013-04-05 | 2018-06-26 | North Carolina Central University | Compounds useful for the treatment of metabolic disorders and synthesis of the same |
| CN103435618B (zh) * | 2013-08-22 | 2016-03-23 | 中国药科大学 | 一种合成稠杂环化合物的方法 |
| JP6580074B2 (ja) * | 2014-05-23 | 2019-09-25 | アクティブ バイオテック エイビー | Ｓ１００阻害薬として有用な新規化合物 |
| CN105859630B (zh) * | 2015-01-22 | 2019-01-18 | 北京大学 | 一种咪唑酮衍生物的合成方法及应用 |
| EP3150604B1 (en) | 2015-10-01 | 2021-07-14 | Idemitsu Kosan Co., Ltd. | Benzimidazolo[1,2-a]benzimidazole carrying benzimidazolo[1,2-a]benzimidazolylyl groups, carbazolyl groups, benzofurane groups or benzothiophene groups for organic light emitting diodes |
| WO2017056055A1 (en) | 2015-10-01 | 2017-04-06 | Idemitsu Kosan Co., Ltd. | Benzimidazolo[1,2-a]benzimidazole carrying triazine groups for organic light emitting diodes |
| WO2018220513A1 (en) * | 2017-05-31 | 2018-12-06 | Alembic Pharmaceuticals Limited | An improved process for preparation of obeticholic acid |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS516993A (en) | 1974-07-05 | 1976-01-20 | Dainippon Pharmaceutical Co | Adeninjudotaino seiho |
| ES2294047T3 (es) * | 2000-12-28 | 2008-04-01 | Ono Pharmaceutical Co., Ltd. | Un compuesto de ciclopenta (d) pirazolo(1,5-a) pirimidina como antagonista del receptor de crf. |
| GB0308208D0 (en) * | 2003-04-09 | 2003-05-14 | Glaxo Group Ltd | Chemical compounds |
| US7872133B2 (en) * | 2003-06-23 | 2011-01-18 | Ono Pharmaceutical Co., Ltd. | Tricyclic heterocycle compound |
| EP2522670A1 (en) * | 2004-04-07 | 2012-11-14 | Takeda Pharmaceutical Company Limited | Heterocyclic CRF receptor antagonists |
| TWI370820B (en) * | 2005-04-27 | 2012-08-21 | Takeda Pharmaceutical | Fused heterocyclic compounds |
| JP2010507664A (ja) | 2006-10-25 | 2010-03-11 | 武田薬品工業株式会社 | ベンズイミダゾール化合物 |
| US8039500B2 (en) | 2006-12-29 | 2011-10-18 | Takeda Pharmaceutical Company Limited | Fused heterocyclic compounds |
| CA2711713A1 (en) * | 2008-01-22 | 2009-07-30 | Boehringer Ingelheim International Gmbh | Substituted amino-benzimidazoles, medicaments comprising said compound, their use and their method of manufacture |
| FR2926556B1 (fr) * | 2008-01-22 | 2010-02-19 | Sanofi Aventis | Derives de carboxamides n-azabicycliques, leur preparation et leur application en therapeutique |
| FR2926554B1 (fr) * | 2008-01-22 | 2010-03-12 | Sanofi Aventis | Derives de carboxamides azabicycliques, leur preparation et leur application en therapeutique |
| JO2797B1 (en) * | 2008-01-22 | 2014-03-15 | ايلي ليلي اند كومباني | Selective opioid receptor antagonist kappa |
-
2009
- 2009-01-21 EA EA201070876A patent/EA201070876A1/ru unknown
- 2009-01-21 CA CA2712347A patent/CA2712347A1/en not_active Abandoned
- 2009-01-21 CN CN2009801105455A patent/CN101981031A/zh active Pending
- 2009-01-21 TW TW098102200A patent/TW200936591A/zh unknown
- 2009-01-21 AU AU2009206936A patent/AU2009206936A1/en not_active Abandoned
- 2009-01-21 UY UY031604A patent/UY31604A1/es not_active Application Discontinuation
- 2009-01-21 GE GEAP200911925A patent/GEP20125637B/en unknown
- 2009-01-21 US US12/863,851 patent/US8901141B2/en not_active Expired - Fee Related
- 2009-01-21 US US12/357,158 patent/US8785460B2/en not_active Expired - Fee Related
- 2009-01-21 NZ NZ587215A patent/NZ587215A/xx not_active IP Right Cessation
- 2009-01-21 EP EP09704168.5A patent/EP2240485B1/en active Active
- 2009-01-21 KR KR1020107018307A patent/KR20100130596A/ko not_active Application Discontinuation
- 2009-01-21 AR ARP090100180A patent/AR070218A1/es not_active Application Discontinuation
- 2009-01-21 PE PE2009000069A patent/PE20091439A1/es not_active Application Discontinuation
- 2009-01-21 JP JP2010528624A patent/JP5431341B2/ja not_active Expired - Fee Related
- 2009-01-21 MX MX2010008039A patent/MX2010008039A/es not_active Application Discontinuation
- 2009-01-21 SG SG2013029723A patent/SG189803A1/en unknown
- 2009-01-21 BR BRPI0907230A patent/BRPI0907230A2/pt not_active IP Right Cessation
- 2009-01-21 CL CL2009000116A patent/CL2009000116A1/es unknown
- 2009-01-21 WO PCT/JP2009/051299 patent/WO2009093747A1/en active Application Filing
-
2010
- 2010-07-18 IL IL207074A patent/IL207074A0/en unknown
- 2010-07-21 DO DO2010000226A patent/DOP2010000226A/es unknown
- 2010-07-27 ZA ZA2010/05340A patent/ZA201005340B/en unknown
- 2010-08-13 MA MA33084A patent/MA32438B1/fr unknown
- 2010-08-18 CR CR11636A patent/CR11636A/es not_active Application Discontinuation
- 2010-08-20 CO CO10102942A patent/CO6230982A2/es active IP Right Grant
- 2010-08-20 EC EC2010010414A patent/ECSP10010414A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2712347A1 (en) | 2009-07-30 |
| US20100298287A1 (en) | 2010-11-25 |
| CL2009000116A1 (es) | 2010-08-27 |
| IL207074A0 (en) | 2010-12-30 |
| SG189803A1 (en) | 2013-05-31 |
| MX2010008039A (es) | 2010-08-10 |
| JP5431341B2 (ja) | 2014-03-05 |
| US8785460B2 (en) | 2014-07-22 |
| DOP2010000226A (es) | 2010-10-15 |
| ZA201005340B (en) | 2011-10-26 |
| UY31604A1 (es) | 2009-08-31 |
| EP2240485A1 (en) | 2010-10-20 |
| TW200936591A (en) | 2009-09-01 |
| WO2009093747A1 (en) | 2009-07-30 |
| US20090186879A1 (en) | 2009-07-23 |
| ECSP10010414A (es) | 2010-09-30 |
| AU2009206936A1 (en) | 2009-07-30 |
| CO6230982A2 (es) | 2010-12-20 |
| KR20100130596A (ko) | 2010-12-13 |
| EP2240485B1 (en) | 2014-10-15 |
| BRPI0907230A2 (pt) | 2019-09-24 |
| PE20091439A1 (es) | 2009-10-19 |
| JP2011509923A (ja) | 2011-03-31 |
| CN101981031A (zh) | 2011-02-23 |
| EA201070876A1 (ru) | 2011-04-29 |
| MA32438B1 (fr) | 2011-07-03 |
| GEP20125637B (en) | 2012-09-10 |
| US8901141B2 (en) | 2014-12-02 |
| NZ587215A (en) | 2012-08-31 |
| CR11636A (es) | 2010-11-04 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR070218A1 (es) | COMPUESTOS TRICíCLICOS, SUS PROFÁRMACOS, UNA COMPOSICIoN FARMACÉUTICA QUE LOS COMPRENDE Y SU USO EN LA PRODUCCIoN DE UN MEDICAMENTO PARA EL TRATAMIENTO DE ENFERMEDADES MEDIADAS POR EL RECEPTOR CRF. | |
| UY31069A1 (es) | Nuevos derivados de imidazoquinola, composiciones conteniendolos, proceso de preparacion y aplicaciones | |
| UY32296A (es) | Nuevos compuestos | |
| ECSP15012804A (es) | Alcoxipirazoles como activadores de guanilato ciclasa soluble | |
| GT201400031A (es) | Derivados de 2-amino-4-(piridin-2-il)-5,6-dihidro-4h-1,3-oxazina y su uso como inhibidores de bace-1 y/o bace-2 | |
| UY32648A (es) | Nuevos derivados de pirimidina y su uso en el tratamiento de enfermedades | |
| CO6382155A2 (es) | Agonistas del receptor gpr120 de arilo y usos de los mismos | |
| ECSP109856A (es) | Derivados de oxadiazol y su uso como potenciadores de los receptores metabotrópicos de glutamato - 842 | |
| NI201002091A (es) | Derivados de isoxazol y su uso como potenciadores de los receptores metabotrópicos de glutamato. | |
| UY32611A (es) | Compuestos de 1-cianoetilheterociclilcarboxamida sustituidos 750 | |
| CL2012000589A1 (es) | Compuestos derivados de pirrolo piridin carboxamidas, inhibidores de jak2; composición farmacéutica que los comprende; uso en el tratamiento de enfermedades mieloproliferativas o cáncer, tales como policitemia vera, trombocitopenia esencial, mieloma múltiple, entre otras. | |
| UY29988A1 (es) | Compuestos de oxazolidinona y su uso como potenciadores del receptor metabotrópico de glutamato | |
| UY33078A (es) | Derivados de imidazoquinolina | |
| UY33458A (es) | Derivados de metoxifenilo heterocíclicamente sustituidos con un grupo oxo, procedimientos para su preparación y uso de los mismos como medicamentos | |
| UY32574A (es) | Antagonistas del receptor cxcr3 | |
| ECSP14013215A (es) | Compuestos novedosos | |
| UY33075A (es) | Derivados de ciclohexano y usos de los mismos | |
| DOP2009000200A (es) | Derivados de 2-amino-5,7-dihidro-6h-pirrolo[3,4-d] pimiridina como inhibidores hsp-90 para tratar el cancer | |
| ECSP099751A (es) | Derivados de 9-(pirazol-3-il)-9h-purin-2-amina y 3-(pirazol-3-il)-3h-imidazo[4,5-b]piridin-5-amina y su uso para el tratamiento del cáncer | |
| BR112012001817B8 (pt) | furazanobenzimidazóis, seu uso, processo de produção e composição farmacêutica | |
| CR10356A (es) | Derivados de 4-benzilphthalazinona 2-sustituidos como antagonistas de histamina h1 y h3 | |
| AR078278A1 (es) | Antagonistas de la tiazol y oxazol hepcidina, composiciones farmaceuticas que los contienen y uso de los mismos para el tratamiento de anemias y enfermedades asociadas a deficiencias de hierro. | |
| ECSP099425A (es) | Derivados de amina y su uso en enfermedades mediadas por el adrenorecetor beta 2 | |
| UY32055A (es) | Derivados sustituidos de la 5-Halo-N2-[sustituido](1-metil-1H-imidazol-4-il)pirimidin-2,-diamina y sus sales farmacéuticamente aceptables, procesos de preparación, composiciones y aplicaciones. | |
| UY32674A (es) | Derivados heterociclicos de la urea y sus metodos de empleo |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |