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CA3005766A1 - Antagonistes de tlr7/8 polycyliques et leur utilisation dans le traitement de maladies immunes - Google Patents

Antagonistes de tlr7/8 polycyliques et leur utilisation dans le traitement de maladies immunes Download PDF

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Publication number
CA3005766A1
CA3005766A1 CA3005766A CA3005766A CA3005766A1 CA 3005766 A1 CA3005766 A1 CA 3005766A1 CA 3005766 A CA3005766 A CA 3005766A CA 3005766 A CA3005766 A CA 3005766A CA 3005766 A1 CA3005766 A1 CA 3005766A1
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compound
ring
chemical structure
disease
nrc
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Brian A. Sherer
Nadia Brugger
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Merck Patent GmbH
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Merck Patent GmbH
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Publication of CA3005766A1 publication Critical patent/CA3005766A1/fr
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/541—Non-condensed thiazines containing further heterocyclic rings
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    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
    • C07D241/40—Benzopyrazines
    • C07D241/42—Benzopyrazines with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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Abstract

L'invention concerne des composés de formule (I) et des compositions pharmaceutiquement acceptables de ceux-ci, servant d'antagonistes du récepteur de type Toll 7/8. Dans la formule (I), le cycle A est aryle ou hétéroaryle; le cycle B est aryle ou hétéroaryle; et X est C(R4)2, O, NR4, S, S(R4), ou S(R4)2.
CA3005766A 2015-12-17 2016-12-16 Antagonistes de tlr7/8 polycyliques et leur utilisation dans le traitement de maladies immunes Pending CA3005766A1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562268765P 2015-12-17 2015-12-17
US62/268,765 2015-12-17
US201662353603P 2016-06-23 2016-06-23
US62/353,603 2016-06-23
PCT/US2016/067112 WO2017106607A1 (fr) 2015-12-17 2016-12-16 Antagonistes de tlr7/8 polycyliques et leur utilisation dans le traitement de maladies immunes

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CA3005766A1 true CA3005766A1 (fr) 2017-06-22

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US (6) US10399957B2 (fr)
EP (3) EP3390389B1 (fr)
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KR (1) KR20180094939A (fr)
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AU (3) AU2016371014B2 (fr)
CA (1) CA3005766A1 (fr)
CL (1) CL2018001624A1 (fr)
DK (1) DK3889145T3 (fr)
ES (2) ES2981114T3 (fr)
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UA (1) UA124802C2 (fr)
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Families Citing this family (94)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3005766A1 (fr) 2015-12-17 2017-06-22 Merck Patent Gmbh Antagonistes de tlr7/8 polycyliques et leur utilisation dans le traitement de maladies immunes
TWI808055B (zh) 2016-05-11 2023-07-11 美商滬亞生物國際有限公司 Hdac 抑制劑與 pd-1 抑制劑之組合治療
TWI794171B (zh) 2016-05-11 2023-03-01 美商滬亞生物國際有限公司 Ｈｄａｃ抑制劑與ｐｄ-ｌ１抑制劑之組合治療
KR20210134838A (ko) 2016-07-14 2021-11-10 크리네틱스 파마슈티칼스, 인크. 소마토스타틴 조절제 및 그의 용도
CN109563075B (zh) * 2016-08-08 2022-09-30 默克专利股份公司 Tlr7/8拮抗剂及其用途
CA3040143A1 (fr) 2016-10-14 2018-04-19 Precision Biosciences, Inc. Meganucleases modifiees specifiques de sequences de reconnaissance dans le genome du virus de l'hepatite b
EP3538513A1 (fr) * 2016-11-11 2019-09-18 Dynavax Technologies Corporation Composés antagonistes du récepteur de type toll et leurs méthodes d'utilisation
DK3655401T3 (da) * 2017-07-18 2023-10-30 Merck Patent Gmbh Tlr7/8-antagonister og anvendelser deraf
CN111542515B (zh) * 2017-10-30 2023-12-05 科罗拉多州立大学董事会法人团体 Toll样受体8(tlr8)特异性拮抗剂及其制备方法和用途
RU2020123151A (ru) * 2017-12-19 2022-01-20 Мерк Патент Гмбх Антагонисты tlr7/8 и их применение
EP3728282B1 (fr) 2017-12-20 2023-11-22 Institute of Organic Chemistry and Biochemistry ASCR, V.V.I. Dinucléotides 2'3' cycliques ayant une liaison phosphonate activant la protéine adaptatrice de sting
AU2018392213B2 (en) 2017-12-20 2021-03-04 Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. 3'3' cyclic dinucleotides with phosphonate bond activating the STING adaptor protein
WO2019155042A1 (fr) 2018-02-12 2019-08-15 F. Hoffmann-La Roche Ag Nouveaux composés et dérivés de sulfone pour le traitement et la prophylaxie d'une infection virale
CN111788204B (zh) 2018-02-26 2023-05-05 吉利德科学公司 作为hbv复制抑制剂的取代吡咯嗪化合物
US10870691B2 (en) 2018-04-05 2020-12-22 Gilead Sciences, Inc. Antibodies and fragments thereof that bind hepatitis B virus protein X
TWI833744B (zh) 2018-04-06 2024-03-01 捷克科學院有機化學與生物化學研究所 3'3'-環二核苷酸
TWI818007B (zh) 2018-04-06 2023-10-11 捷克科學院有機化學與生物化學研究所 2'3'-環二核苷酸
TW202005654A (zh) 2018-04-06 2020-02-01 捷克科學院有機化學與生物化學研究所 ２，２，─環二核苷酸
TW201945388A (zh) 2018-04-12 2019-12-01 美商精密生物科學公司 對b型肝炎病毒基因體中之識別序列具有特異性之最佳化之經工程化巨核酸酶
TW202014193A (zh) 2018-05-03 2020-04-16 捷克科學院有機化學與生物化學研究所 包含碳環核苷酸之2’3’－環二核苷酸
AU2019280728A1 (en) * 2018-06-05 2020-11-12 F. Hoffmann-La Roche Ag Tetrahydro-1 H-pyrazino[2,1 -ajisoindolylquinoline compounds for the treatment of autoimmune disease
JP7434186B2 (ja) * 2018-06-12 2024-02-20 エフ． ホフマン－ラ ロシュ アーゲー 自己免疫疾患の処置のための新規のヘテロアリールヘテロシクリル化合物
CN112585134A (zh) * 2018-06-13 2021-03-30 豪夫迈·罗氏有限公司 用于治疗自身免疫性疾病的吡啶基杂环基化合物
BR112020026681A2 (pt) 2018-06-27 2021-04-06 Bristol-Myers Squibb Company Compostos naftiridinona substituídos úteis como ativadores de célula t
FI3814347T3 (fi) 2018-06-27 2023-06-12 Bristol Myers Squibb Co Naftyridinoniyhdisteitä, jotka ovat käyttökelpoisia t-solun aktivoijina
EP3818052A1 (fr) * 2018-07-06 2021-05-12 Gilead Sciences, Inc. Composés hétérocycliques thérapeutiques
US20220363667A1 (en) * 2018-07-17 2022-11-17 Nippon Chemiphar Co., Ltd. T-type calcium channel blocker
WO2020020800A1 (fr) * 2018-07-23 2020-01-30 F. Hoffmann-La Roche Ag Nouveaux composés de pipérazine pour le traitement d'une maladie auto-immune
BR122023023308A2 (pt) * 2018-07-31 2024-02-20 Merck Patent Gmbh Antagonistas tlr7/8, seus usos, composição farmacêutica, e kit
WO2020028097A1 (fr) 2018-08-01 2020-02-06 Gilead Sciences, Inc. Formes solides d'acide (r)-11-(méthoxyméthyl)-12-(3-méthoxypropoxy)-3,3-diméthyl-8-0 x0-2,3,8,13b-tétrahydro-1h-pyrido[2,1-a] pyrrolo[1,2-c]phtalazine-7-carboxylique
JP2021535144A (ja) 2018-08-28 2021-12-16 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft 自己免疫疾患を治療するための新規のピロリジニルアミド化合物
CN112638908A (zh) * 2018-09-04 2021-04-09 豪夫迈·罗氏有限公司 用于治疗自身免疫性疾病的苯并噻唑类化合物
CN112654618A (zh) 2018-09-06 2021-04-13 豪夫迈·罗氏有限公司 用于治疗自身免疫性疾病的新型环脒化合物
CN112654620B (zh) * 2018-09-06 2023-08-04 豪夫迈·罗氏有限公司 用于治疗自身免疫性疾病的新型吡唑并吡啶化合物
US20210253575A1 (en) * 2018-09-07 2021-08-19 Hoffmann-La Roche Inc. Pyrrolidine amine compounds for the treatment of autoimmune disease
US20220112187A1 (en) * 2018-09-11 2022-04-14 Hoffmann-La Roche Inc. Pyrazolopyridine amine compounds for the treatment of autoimmune disease
EP3623369B1 (fr) 2018-09-12 2023-10-25 F. Hoffmann-La Roche AG Nouveaux composés de morpholinyle amine pour le traitement des maladies auto-immunes
US20210395239A1 (en) * 2018-09-27 2021-12-23 Hoffmann-La Roche Inc. Heterocyclyl compounds for the treatment of autoimmune disease
MX2021005047A (es) 2018-10-31 2021-09-08 Gilead Sciences Inc Compuestos de 6-azabenzimidazol sustituidos como inhibidores de hpk1.
CN109516925B (zh) * 2018-10-31 2021-07-16 陕西慧康生物科技有限责任公司 一种谷氨酸-1-甲酯-5-叔丁酯的合成方法
TW202136261A (zh) 2018-10-31 2021-10-01 美商基利科學股份有限公司 經取代之6-氮雜苯并咪唑化合物
EP3877388B1 (fr) * 2018-11-09 2023-07-26 F. Hoffmann-La Roche AG Dérivés de 5-[6-[[3-(4,5,6,7-tetrahydropyrazolo[4,3-c]pyridin-1-yl)azétidin-1-yl]méthyl]morpholin-4-yl]quinoline-8-carbonitrile et composés similaires en tant qu'antagonistes tlr7-9 pour le traitement de lupus erythematosus systèmique
CN109369571A (zh) * 2018-12-04 2019-02-22 无锡市赛乐新材料科技有限公司 一种含氟取代的7-溴-4-醛基苯并噻二唑及其合成方法
US10689360B1 (en) * 2019-01-30 2020-06-23 Insilico Medicine Ip Limited TLR inhibitors
US11807622B2 (en) 2019-01-30 2023-11-07 Insilico Medicine Ip Limited TLR 9 inhibitors
US11008303B2 (en) 2019-01-30 2021-05-18 Insilico Medicine Ip Limited TLR 9 inhibitors
JP7350871B2 (ja) 2019-03-07 2023-09-26 インスティチュート オブ オーガニック ケミストリー アンド バイオケミストリー エーエスシーアール，ヴイ．ヴイ．アイ． ２’３’－環状ジヌクレオチドおよびそのプロドラッグ
US11766447B2 (en) 2019-03-07 2023-09-26 Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. 3′3′-cyclic dinucleotide analogue comprising a cyclopentanyl modified nucleotide as sting modulator
CA3129011C (fr) 2019-03-07 2023-12-19 Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. Dinucleotides 3'3'-cycliques et leurs promedicaments
JP2022081710A (ja) * 2019-03-29 2022-06-01 ユーティアイ リミテッド パートナーシップ 関節リウマチを治療するためのｔ型カルシウムチャネル阻害剤の使用
EP3950059A4 (fr) * 2019-03-29 2023-01-11 Nippon Chemiphar Co., Ltd. Utilisation de bloqueur des canaux calciques de type t servant au traitement du prurit
AU2020272467A1 (en) * 2019-04-09 2021-10-14 F. Hoffmann-La Roche Ag Hexahydro-1H-pyrazino(1,2-a)pyrazine compounds for the treatment of autoimmune disease
TWI751517B (zh) 2019-04-17 2022-01-01 美商基利科學股份有限公司 類鐸受體調節劑之固體形式
TW202210480A (zh) 2019-04-17 2022-03-16 美商基利科學股份有限公司 類鐸受體調節劑之固體形式
WO2020237025A1 (fr) 2019-05-23 2020-11-26 Gilead Sciences, Inc. Exo-méthylène-oxindoles substitués qui sont des inhibiteurs de hpk1/map4k1
CN112094224B (zh) * 2019-06-18 2022-08-26 浙江医药股份有限公司新昌制药厂 一种带保护基的3-取代-5-氨基哌啶的制备方法
WO2021034804A1 (fr) 2019-08-19 2021-02-25 Gilead Sciences, Inc. Formulations pharmaceutiques de ténofovir alafénamide
CN112430208A (zh) * 2019-08-26 2021-03-02 东莞市东阳光仿制药研发有限公司 一种pf-06651600中间体的制备方法
AR119821A1 (es) 2019-08-28 2022-01-12 Bristol Myers Squibb Co Compuestos de piridopirimidinonilo sustituidos útiles como activadores de células t
EP4028125A1 (fr) * 2019-09-10 2022-07-20 F. Hoffmann-La Roche AG Nouveaux composés de quinoléine pour le traitement d'une maladie auto-immune
EP4031539A1 (fr) 2019-09-16 2022-07-27 F. Hoffmann-La Roche AG Composés de pipéridinyl amine pour le traitement d'une maladie auto-immune
AU2020357502A1 (en) 2019-09-30 2022-05-19 Gilead Sciences, Inc. HBV vaccines and methods treating HBV
CA3158150A1 (fr) 2019-10-18 2021-04-22 The Regents Of The University Of California Derives de 3-phenylsulfonyl-quinoleine en tant qu'agents pour le traitement de troubles des vaisseaux sanguins pathogenes
CN114599652B (zh) * 2019-10-31 2024-07-12 豪夫迈·罗氏有限公司 用于治疗自身免疫性疾病的氢吡嗪并[1,2-d][1,4]二氮杂䓬化合物
EP4058452A1 (fr) * 2019-11-12 2022-09-21 F. Hoffmann-La Roche AG Composés d'hydropyrazino[1,2-b]isoquinoline pour le traitement d'une maladie auto-immune
US20230002415A1 (en) * 2019-11-20 2023-01-05 Hoffmann-La Roche Inc. Spiro(isobenzofuranazetidine) compounds for the treatment of autoimmune disease
BR112022009856A2 (pt) * 2019-11-26 2022-08-02 Hoffmann La Roche Compostos de 1,8-naftiridin-2-ona para o tratamento de doença autoimune
KR20220122637A (ko) 2019-11-28 2022-09-02 바이엘 악티엔게젤샤프트 면역 활성화를 위한 dgk알파 억제제로서의 치환된 아미노퀴놀론
US20230022297A1 (en) * 2019-12-03 2023-01-26 Hoffmann-La Roche Inc. HYDROPYRIDO[1,2-a]PYRAZINE COMPOUNDS FOR THE TREATMENT OF AUTOIMMUNE DISEASE
WO2021113765A1 (fr) 2019-12-06 2021-06-10 Precision Biosciences, Inc. Méganucléases modifiées optimisées ayant une spécificité pour une séquence de reconnaissance dans un génome du virus de l'hépatite b
EP4077322A1 (fr) 2019-12-18 2022-10-26 Intervet International B.V. Composés anthelminthiques comprenant une structure d'azaindoles
AR120823A1 (es) 2019-12-23 2022-03-23 Bristol Myers Squibb Co Compuestos bicíclicos sustituidos útiles como activadores de células t
CN115605493A (zh) 2020-03-20 2023-01-13 吉利德科学公司（Us） 4′-c-取代的-2-卤代-2′-脱氧腺苷核苷的前药及其制备和使用方法
CA3177685A1 (fr) * 2020-05-14 2021-11-18 Julie A. Demartino Antagonistes de tlr7/8 pour le traitement d'infections a coronavirus
US20230301981A1 (en) * 2020-06-15 2023-09-28 Merck Patent Gmbh Tlr7/8 antagonists and uses thereof
US20240350492A1 (en) 2020-07-10 2024-10-24 Ting Therapeutics Llc Methods for the Prevention and Treatment of Hearing Loss
TW202214632A (zh) * 2020-07-27 2022-04-16 大陸商江蘇恆瑞醫藥股份有限公司 吲哚稠環類衍生物、其製備方法及其在醫藥上的應用
WO2022028389A1 (fr) * 2020-08-03 2022-02-10 江苏恒瑞医药股份有限公司 Dérivé tricyclique fusionné, son procédé de préparation et son utilisation pharmaceutique
CN114057754B (zh) * 2020-08-07 2023-05-16 江苏恒瑞医药股份有限公司 含氮桥环类衍生物、其制备方法及其在医药上的应用
CA3191084A1 (fr) 2020-09-09 2022-03-17 Gerald Burke Formulations d'un modulateur de somatostatine
WO2022067462A1 (fr) * 2020-09-29 2022-04-07 Beigene (Beijing) Co., Ltd. Procédé de préparation d'inhibiteurs de kras g12c
MX2023006193A (es) 2020-11-26 2023-06-09 Jiangsu Hengrui Pharmaceuticals Co Ltd Compuesto triciclico fusionado, metodo de preparacion y aplicacion del mismo en medicina.
KR102513463B1 (ko) * 2020-11-26 2023-03-29 주식회사 에스앤케이테라퓨틱스 엔도솜 톨-유사 수용체를 제어하는 신규 소분자 화합물 및 이를 이용한 자가면역질환 치료제
WO2022194237A1 (fr) * 2021-03-18 2022-09-22 成都百裕制药股份有限公司 Dérivé de quinoléine et son application dans la préparation d'un médicament auto-immun
PE20240919A1 (es) 2021-04-16 2024-04-30 Gilead Sciences Inc Compuestos de tienopirrol
EP4337223A1 (fr) 2021-05-13 2024-03-20 Gilead Sciences, Inc. Combinaison d'un composé de modulation de tlr8 et agent thérapeutique anti-arnsi de vhb
CA3222277A1 (fr) 2021-06-23 2022-12-29 Gilead Sciences, Inc. Composes modulant les diacylglycerol kinases
WO2022271659A1 (fr) 2021-06-23 2022-12-29 Gilead Sciences, Inc. Composés modulant les diacylglycérol kinases
IL309378A (en) 2021-06-23 2024-02-01 Gilead Sciences Inc DIACYLGLYERCOL KINASE MODULATING COMPOUNDS
CA3222595A1 (fr) 2021-06-23 2022-12-29 Gilead Sciences, Inc. Composes de modulation de la diacylglycerol kinase
KR20240056747A (ko) 2021-09-10 2024-04-30 길리애드 사이언시즈, 인코포레이티드 티에노피롤 화합물
CN115160296B (zh) * 2022-08-08 2024-05-28 西安市第五医院 一种n-取代喹啉-4-胺类化合物及其制备、药物组合物和应用
CN115650881A (zh) * 2022-09-06 2023-01-31 浙江医药股份有限公司新昌制药厂 一种利用微反应器合成喹诺酮类化合物中间体的工艺方法
WO2024153063A1 (fr) * 2023-01-18 2024-07-25 苏州科睿思制药有限公司 Forme cristalline d'enpatoran, son procédé de préparation et son utilisation

Family Cites Families (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1020252A (en) * 1911-04-26 1912-03-12 Arthur H Bell Brooder.
US1016829A (en) * 1911-05-19 1912-02-06 Abraham Hurwitz Device for setting pallet-jewels.
US1227293A (en) * 1914-04-10 1917-05-22 Charles H Morison Safety-catch for cuff-buttons.
US1271680A (en) * 1918-01-15 1918-07-09 Emanuel W Dunn Heater.
US1367747A (en) * 1919-05-07 1921-02-08 George B Keplinger Bath-brush
DE812911C (de) 1945-03-12 1951-09-06 Rhone Poulenc Sa Verfahren zur Herstellung von neuen substituierten Derivaten des Piperidins
CH578535A5 (en) 1973-05-11 1976-08-13 Ciba Geigy Ag Quinoline-3-carboxylic acid derivs - with e.g. analgesic, antinociceptive, antiinflammatory and antiallergic props
US4933447A (en) * 1987-09-24 1990-06-12 Ss Pharmaceutical Co., Ltd. Quinoline derivatives
FR2798656B1 (fr) 1999-09-17 2004-12-17 Aventis Pharma Sa Derives de la quinolyl propyl piperidine, leur preparation et les compositions qui les contiennent
WO2003042208A1 (fr) 2001-11-14 2003-05-22 Merck Patent Gmbh Derives de pyrazole utilises en tant que produits psychopharmaceutiques
GB0206033D0 (en) 2002-03-14 2002-04-24 Pfizer Ltd Compounds useful in therapy
WO2003105850A1 (fr) 2002-06-18 2003-12-24 Abbott Laboratories 2-aminoquinolines servant d'antagonistes de recepteur de l'hormone de concentration de melanine
NZ538713A (en) 2002-08-12 2007-01-26 Takeda Chemical Industries Ltd Fused benzene derivative and use
JP2006508113A (ja) 2002-11-12 2006-03-09 ファイザー・プロダクツ・インク キノリン誘導体
GB0227240D0 (en) 2002-11-21 2002-12-31 Glaxo Group Ltd Compounds
GB0229281D0 (en) * 2002-12-16 2003-01-22 Novartis Ag Organic compounds
US20050124625A1 (en) * 2003-10-21 2005-06-09 Salvati Mark E. Piperazine derivatives and their use as modulators of nuclear hormone receptor function
EP1726584A4 (fr) 2004-03-15 2009-05-13 Kyowa Hakko Kirin Co Ltd Derive de 2-aminoquinazoline
US20060211752A1 (en) 2004-03-16 2006-09-21 Kohn Leonard D Use of phenylmethimazoles, methimazole derivatives, and tautomeric cyclic thiones for the treatment of autoimmune/inflammatory diseases associated with toll-like receptor overexpression
AU2005247405A1 (en) 2004-05-17 2005-12-08 Acadia Pharmaceuticals Inc. Androgen receptor modulators and method of treating disease using the same
US20070004679A1 (en) 2004-05-17 2007-01-04 Nathalie Schlienger Androgen receptor modulators and methods of treating disease using the same
CN101023083A (zh) * 2004-07-23 2007-08-22 田边制药株式会社 含氮的稠合双环化合物
EP1772454A4 (fr) * 2004-07-23 2009-02-25 Mitsubishi Tanabe Pharma Corp Composé bicyclique azoté
US20090264415A2 (en) * 2004-12-30 2009-10-22 Steven De Jonghe Pyrido(3,2-d)pyrimidines and pharmaceutical compositions useful for medical treatment
GB0510810D0 (en) 2005-05-26 2005-06-29 Novartis Ag Organic compounds
GB0526042D0 (en) 2005-12-21 2006-02-01 Syngenta Participations Ag Chemical compounds
WO2007097289A1 (fr) 2006-02-20 2007-08-30 Takeda Pharmaceutical Company Limited Nouvelle substance pharmaceutique
BRPI0715888B1 (pt) * 2006-08-23 2021-11-03 Kudos Pharmaceuticals Limited Composto ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica, e, uso de um composto
EP1903038A1 (fr) * 2006-09-07 2008-03-26 Bayer Schering Pharma Aktiengesellschaft Dérivés N-(1-hetaryl-piperidine-4-yl)-(het)arylamide utilisées comme modulateurs du recepteur EP2
WO2008037681A1 (fr) 2006-09-26 2008-04-03 Glaxo Group Limited Dérivés de quinolinone 5-{2-[4-(2-méthyl-5-quinolinyl)-l-pipéridinyl] éthyl} utilisés comme modulateurs du récepteur 5ht1a pour le traitement des disfonctionnements sexuels, des anomalies cognitives, des troubles psychotiques, de l'anxiété, de la dépressi
CL2008001002A1 (es) 2007-04-11 2008-10-17 Actelion Pharmaceuticals Ltd Compuestos derivados de oxazolidinona; composicion farmaceutica que comprende a dichos compuestos; y su uso para preparar un medicamento para tratar una infeccion bacteriana.
PT2164825E (pt) 2007-06-05 2014-06-24 Sanofi Sa Derivados de di(hetero)arilciclo-hexano, sua preparação, sua utilização e composições farmacêuticas compreendendo os mesmos
US20110237600A1 (en) 2008-05-12 2011-09-29 Amnestix, Inc. Compounds for improving learning and memory
JP2011526931A (ja) 2008-07-03 2011-10-20 エグゼリクシス， インコーポレイテッド Ｃｄｋモジュレーター
US8735424B2 (en) * 2008-09-02 2014-05-27 Novartis Ag Bicyclic kinase inhibitors
EP2352732B1 (fr) 2008-12-01 2013-02-20 Merck Patent GmbH PYRIDO[4,3-d]PYRIMIDINES 2,5-DIAMINO-SUBSTITUÉES EN TANT QU'INHIBITEURS D'AUTOTAXINE CONTRE LE CANCER
US8729088B2 (en) 2009-02-11 2014-05-20 The Regents Of The University Of California Toll-like receptor modulators and treatment of diseases
ES2432070T3 (es) * 2009-02-24 2013-11-29 Respiratorius Ab Diazaheteroarilos broncodilatadores novedosos
CA2768236C (fr) 2009-07-16 2018-05-22 Mallinckrodt Llc (+)-morphinanes en tant qu'antagonistes du recepteur de type toll 9 et utilisations therapeutiques de celles-ci
US20120214803A1 (en) * 2011-02-18 2012-08-23 Vifor (International) Ag Novel Sulfonaminoquinoline Hepcidin Antagonists
WO2013060881A1 (fr) 2011-10-27 2013-05-02 Vereniging Voor Christelijk Hoger Onderwijs, Wetenschappelijk Onderzoek En Patientenzorg Pyridopyrimidines et leur utilisation thérapeutique
WO2014086453A1 (fr) 2012-12-07 2014-06-12 Merck Patent Gmbh Composés azahétérobicycliques
RU2708395C2 (ru) 2013-06-26 2019-12-06 Эббви Инк. Первичные карбоксамиды в качестве ингибиторов bтk
TWI529171B (zh) * 2013-07-29 2016-04-11 赫孚孟拉羅股份公司 １，７－萘啶衍生物
CN105682661B (zh) 2013-08-23 2020-03-27 润新生物公司 某些化学实体、组合物和方法
HUE048706T2 (hu) 2013-10-14 2020-08-28 Eisai R&D Man Co Ltd Szelektíven szubsztituált kinolin-vegyületek
JP6483666B2 (ja) * 2013-10-14 2019-03-13 エーザイ・アール・アンド・ディー・マネジメント株式会社 選択的に置換されたキノリン化合物
CN104557913B (zh) 2013-10-28 2017-02-08 上海汇伦生命科技有限公司 吡啶并嘧啶类化合物，其制备方法和用途
JP2016540013A (ja) * 2013-12-13 2016-12-22 武田薬品工業株式会社 Ｔｌｒ阻害剤としてのピロロ［３，２−ｃ］ピリジン誘導体
ES2663622T3 (es) 2013-12-17 2018-04-16 Pfizer Inc. Novedosas 1H-pirrolo[2,3-b]piridinas 3,4-disustituidas y 7H-pirrolo[2,3-c]piridacinas 4,5-disustituidas como inhibidores de LRRK2
CN106536523A (zh) 2014-02-05 2017-03-22 斯特里奥肯公司 西他列汀的权宜合成
CN104945377A (zh) 2014-03-24 2015-09-30 南京明德新药研发股份有限公司 作为smo抑制剂的喹啉衍生物
US9938292B2 (en) 2014-03-24 2018-04-10 Guangdong Zhongsheng Pharmaceutical Co., Ltd Quinoline derivatives as SMO inhibitors
DK3134402T3 (da) 2014-04-22 2020-07-20 Hoffmann La Roche 4-amino-imidazoquinolinforbindelser
GB201411236D0 (en) 2014-06-25 2014-08-06 Takeda Pharmaceutical Novel compounds
RU2719446C2 (ru) 2014-11-03 2020-04-17 Айомет Фарма Лтд Фармацевтическое соединение
UY36390A (es) 2014-11-05 2016-06-01 Flexus Biosciences Inc Compuestos moduladores de la enzima indolamina 2,3-dioxigenasa (ido), sus métodos de síntesis y composiciones farmacéuticas que los contienen
WO2016087593A1 (fr) 2014-12-05 2016-06-09 Syngenta Participations Ag Nouvelles quinolinylamidines fongicides
MA41169A (fr) 2014-12-17 2017-10-24 Acraf Composés antibactériens à large spectre d'activité
US10167270B2 (en) 2015-07-01 2019-01-01 Northwestern University Substituted quinazoline compounds and uses thereof for modulating glucocerebrosidase activity
WO2017031427A1 (fr) 2015-08-19 2017-02-23 3-V Biosciences, Inc. Composés et procédés d'inhibition de mtor
CA3005766A1 (fr) 2015-12-17 2017-06-22 Merck Patent Gmbh Antagonistes de tlr7/8 polycyliques et leur utilisation dans le traitement de maladies immunes
CN109563075B (zh) 2016-08-08 2022-09-30 默克专利股份公司 Tlr7/8拮抗剂及其用途
DK3655401T3 (da) 2017-07-18 2023-10-30 Merck Patent Gmbh Tlr7/8-antagonister og anvendelser deraf
RU2020123151A (ru) 2017-12-19 2022-01-20 Мерк Патент Гмбх Антагонисты tlr7/8 и их применение
BR122023023308A2 (pt) * 2018-07-31 2024-02-20 Merck Patent Gmbh Antagonistas tlr7/8, seus usos, composição farmacêutica, e kit

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