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CA2255855A1 - Process to eliminate haemoglobin errors during the determination of albumin - Google Patents

Process to eliminate haemoglobin errors during the determination of albumin

Info

Publication number
CA2255855A1
CA2255855A1 CA002255855A CA2255855A CA2255855A1 CA 2255855 A1 CA2255855 A1 CA 2255855A1 CA 002255855 A CA002255855 A CA 002255855A CA 2255855 A CA2255855 A CA 2255855A CA 2255855 A1 CA2255855 A1 CA 2255855A1
Authority
CA
Canada
Prior art keywords
albumin
present
test wavelength
haemoglobin
eliminate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002255855A
Other languages
French (fr)
Other versions
CA2255855C (en
Inventor
Ralph Weisheit
Barbara Masters
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics GmbH
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19622091A external-priority patent/DE19622091A1/en
Application filed by Individual filed Critical Individual
Publication of CA2255855A1 publication Critical patent/CA2255855A1/en
Application granted granted Critical
Publication of CA2255855C publication Critical patent/CA2255855C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6827—Total protein determination, e.g. albumin in urine
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The invention concerns a method for assaying albumin in a sample containing free hemoglobin by means of optical measurements using at feast two wavelengths, where (a) an adequately strong albumin measuring signal is present at a first test wavelength, (b) with respect to the second test wavelength, (i) no albumin measurement signal is present or (ii) a substantially smaller albumin measurement signal is present compared to that of the first test wavelength, and (c) a comparable strong interference signal is present in the first and in the second test wavelength, said interference signal being time-dependent and having been generated by a reaction of hemoglobin with the assay reagent used to assay the albumin.
CA002255855A 1996-05-31 1997-06-02 Process to eliminate haemoglobin errors during the determination of albumin Expired - Fee Related CA2255855C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DE19622091.2 1996-05-31
DE19622091A DE19622091A1 (en) 1996-05-31 1996-05-31 Accurate measurement of albumin in solution also containing haemoglobin
US4799797P 1997-05-28 1997-05-28
US60/047,997 1997-05-28
PCT/EP1997/002862 WO1997045728A1 (en) 1996-05-31 1997-06-02 Process to eliminate haemoglobin errors during the determination of albumin

Publications (2)

Publication Number Publication Date
CA2255855A1 true CA2255855A1 (en) 1997-12-04
CA2255855C CA2255855C (en) 2005-10-11

Family

ID=26026235

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002255855A Expired - Fee Related CA2255855C (en) 1996-05-31 1997-06-02 Process to eliminate haemoglobin errors during the determination of albumin

Country Status (15)

Country Link
EP (1) EP0906567B1 (en)
JP (1) JP2000512381A (en)
KR (1) KR20000016035A (en)
CN (1) CN1214770A (en)
AT (1) ATE199781T1 (en)
AU (1) AU3171797A (en)
CA (1) CA2255855C (en)
CZ (1) CZ27198A3 (en)
DK (1) DK0906567T3 (en)
ES (1) ES2155690T3 (en)
HU (1) HUP9900723A2 (en)
IL (1) IL127276A0 (en)
NZ (1) NZ332629A (en)
PL (1) PL330221A1 (en)
WO (1) WO1997045728A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19846301A1 (en) 1998-10-08 2000-04-13 Roche Diagnostics Gmbh Optical assay for determining alkaline phosphatase in samples uses specified primary and secondary measurement wavelengths
DE19846300A1 (en) 1998-10-08 2000-04-13 Roche Diagnostics Gmbh Optical assay for determining alkaline phosphatase in samples uses a specified primary measurement wavelength in combination with a rate blank correction
EP2657681A1 (en) * 2012-04-26 2013-10-30 Roche Diagnostics GmbH Improvement of the sensitivity and the dynamic range of photometric assays by generating multiple calibration curves

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6350743A (en) * 1986-08-20 1988-03-03 Hitachi Ltd Analysis of hemolyzed blood specimen
JPH0635982B2 (en) * 1987-01-07 1994-05-11 株式会社島津製作所 Sensitive assay for antigen-antibody reaction
US5284777A (en) * 1991-03-04 1994-02-08 Isolab, Inc. Combined glycated hemoglobin and immunoturbidometric glycated albumin assay from whole blood lysate
JPH07294519A (en) * 1994-03-04 1995-11-10 Kyoto Daiichi Kagaku:Kk Measurement of component in urine
DE4427492A1 (en) * 1994-08-03 1996-02-08 Boehringer Mannheim Gmbh Method for analyzing a medical sample while avoiding interference from hemolysis

Also Published As

Publication number Publication date
EP0906567B1 (en) 2001-03-14
CA2255855C (en) 2005-10-11
EP0906567A1 (en) 1999-04-07
CN1214770A (en) 1999-04-21
DK0906567T3 (en) 2001-04-17
KR20000016035A (en) 2000-03-25
JP2000512381A (en) 2000-09-19
HUP9900723A2 (en) 1999-07-28
IL127276A0 (en) 1999-09-22
AU3171797A (en) 1998-01-05
ES2155690T3 (en) 2001-05-16
NZ332629A (en) 1999-11-29
CZ27198A3 (en) 1998-07-15
WO1997045728A1 (en) 1997-12-04
PL330221A1 (en) 1999-05-10
ATE199781T1 (en) 2001-03-15

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Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed

Effective date: 20140603