BRPI1009447A2 - métodos de purificação de proteínas imunofarmacêuticas modulares pequenas - Google Patents

métodos de purificação de proteínas imunofarmacêuticas modulares pequenas

Info

Publication number: BRPI1009447A2
Authority: BR; Brazil
Prior art keywords: protein purification; purification methods; small modular; modular immunopharmaceutical; immunopharmaceutical protein
Prior art date: 2009-03-11

Application number

BRPI1009447A

Other languages

English (en)

Inventor

Aaron Noyes

Christopher Gallo

Daniel Lacasse

James Edward Booth

Jason Cormier

Shujun Sun

Original Assignee

Wyeth Llc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2009-03-11

Filing date

2010-03-11

Publication date

2016-03-01

2010-03-11 Application filed by Wyeth Llc filed Critical Wyeth Llc

2016-03-01 Publication of BRPI1009447A2 publication Critical patent/BRPI1009447A2/pt

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/18—Ion-exchange chromatography
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Life Sciences & Earth Sciences (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Analytical Chemistry (AREA)
Immunology (AREA)
Engineering & Computer Science (AREA)
Water Supply & Treatment (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

BRPI1009447A 2009-03-11 2010-03-11 métodos de purificação de proteínas imunofarmacêuticas modulares pequenas BRPI1009447A2 (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US15934709P	2009-03-11	2009-03-11
PCT/US2010/026931 WO2010147686A2 (en)	2009-03-11	2010-03-11	Methods of purifying small modular immunopharmaceutical proteins

Publications (1)

Publication Number	Publication Date
BRPI1009447A2 true BRPI1009447A2 (pt)	2016-03-01

Family

ID=43012630

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI1009447A BRPI1009447A2 (pt)	2009-03-11	2010-03-11	métodos de purificação de proteínas imunofarmacêuticas modulares pequenas

Country Status (11)

Country	Link
US (1)	US20120141497A1 (pt)
EP (1)	EP2406274A2 (pt)
JP (1)	JP2010209068A (pt)
KR (1)	KR20110139216A (pt)
CN (1)	CN102395597A (pt)
AU (1)	AU2010260476A1 (pt)
BR (1)	BRPI1009447A2 (pt)
CA (1)	CA2751000A1 (pt)
IL (1)	IL215082A0 (pt)
RU (1)	RU2011137030A (pt)
WO (1)	WO2010147686A2 (pt)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
MX2012004711A (es) *	2009-10-20	2012-05-23	Abbott Lab	Aislamiento y purificacion de los anticuerpos anti-il-13 al usar cromatografia de afinidad con proteina a.
SG182553A1 (en) *	2010-01-22	2012-08-30	Boehringer Ingelheim Int	Chromatographic method for purifying fc-containing proteins
WO2011156073A1 (en) *	2010-06-08	2011-12-15	Millipore Corporation	Removal of protein aggregates from biopharmaceutical preparations using calcium phosphate salts
AR082963A1 (es)	2010-09-17	2013-01-23	Sumitomo Chemical Co	Composicion para aerosol de control de plagas
EP2627425A4 (en) *	2010-10-11	2014-11-05	Abbvie Inc	METHODS OF PURIFYING PROTEINS
JP6096774B2 (ja) *	2011-08-12	2017-03-15	キアゲンゲゼルシャフトミットベシュレンクテルハフツング	核酸を単離するための方法
CN102492040B (zh) *	2011-12-29	2014-06-25	嘉和生物药业有限公司	一种抗her2或/和抗her3抗体蛋白的纯化方法
CN105051204B (zh)	2012-11-16	2023-07-21	波赛伊达治疗学股份有限公司	位点特异性酶和使用方法
CN102993266B (zh) *	2012-11-30	2019-08-23	广州白云山拜迪生物医药有限公司	一种融合蛋白的纯化和复性方法
JP6457479B2 (ja)	2013-03-14	2019-01-23	アムジエン・インコーポレーテツド	漏出したアフィニティ精製リガンドの除去
CN109627284A (zh) *	2013-03-15	2019-04-16	建新公司	用于生物过程监控的生物治疗剂的基于亲和力的分析纯化
JP2017518082A (ja) *	2014-06-17	2017-07-06	ポセイダセラピューティクス，インコーポレイテッド	ゲノム中の特異的遺伝子座にタンパク質を指向させるための方法およびその使用
EP3180027A4 (en) *	2014-08-15	2018-01-10	Oncomed Pharmaceuticals, Inc.	Rspo1 binding agents and uses thereof
KR102441637B1 (ko)	2014-12-15	2022-09-07	메르크 파텐트 게엠베하	미정제 용액으로부터의 표적 분자 포획
CN104693303B (zh) *	2015-02-28	2018-03-13	苏州金盟生物技术有限公司	一种蛋白制品中的核酸去除方法
AU2016278226B2 (en)	2015-06-17	2021-08-12	Poseida Therapeutics, Inc.	Compositions and methods for directing proteins to specific loci in the genome
JP2019108274A (ja) *	2016-04-18	2019-07-04	昭和電工株式会社	タンパク質凝集体の除去方法
EP3519070A4 (en) *	2016-09-29	2020-05-06	Bio-Rad Laboratories, Inc.	AGAROSE-FILLED CERAMIC APATITE
US11155575B2 (en)	2018-03-21	2021-10-26	Waters Technologies Corporation	Non-antibody high-affinity-based sample preparation, sorbent, devices and methods
WO2020125757A1 (en) *	2018-12-21	2020-06-25	Wuxi Biologics (Shanghai) Co., Ltd.	A method for improving aggregate removal by protein a chromatography
US20220314142A1 (en) *	2019-07-01	2022-10-06	Pfizer Inc.	Improvements to wash solutions for protein a chromatography in an antibody purification process
EP4041312A4 (en)	2019-10-10	2023-12-20	Kodiak Sciences Inc.	METHOD FOR TREATING AN EYE DISORDER
BR112022013481A2 (pt) *	2020-01-08	2022-09-13	Regeneron Pharma	Uso de aminoácidos para aumentar o sinal em análises espectro de massa
CN114901671B (zh) *	2020-01-20	2024-02-20	上海药明生物技术有限公司	用于亲和层析的新的清洗缓冲溶液
AU2023217074A1 (en) *	2022-02-10	2024-08-15	Kodiak Sciences Inc.	Methods of purifying a product
CN115894604B (zh) *	2022-12-16	2024-01-23	康日百奥生物科技(苏州)有限公司	重组蛋白澄清纯化方法
CN116120392B (zh) *	2023-04-18	2023-08-01	上海健士拜生物科技有限公司	聚体蛋白的纯化方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7829084B2 (en)	2001-01-17	2010-11-09	Trubion Pharmaceuticals, Inc.	Binding constructs and methods for use thereof
US20030133939A1 (en)	2001-01-17	2003-07-17	Genecraft, Inc.	Binding domain-immunoglobulin fusion proteins
PL364623A1 (en)	2001-01-17	2004-12-13	Trubion Pharmaceuticals, Inc.	Binding domain-immunoglobulin fusion proteins
US7754208B2 (en)	2001-01-17	2010-07-13	Trubion Pharmaceuticals, Inc.	Binding domain-immunoglobulin fusion proteins
US20040058445A1 (en)	2001-04-26	2004-03-25	Ledbetter Jeffrey Alan	Activation of tumor-reactive lymphocytes via antibodies or genes recognizing CD3 or 4-1BB
EP3095793B1 (en)	2003-07-28	2020-03-25	Genentech, Inc.	Reducing protein a leaching during protein a affinity chromatography
RU2409591C2 (ru) *	2003-10-27	2011-01-20	Вайет	Удаление агрегатов с высокой молекулярной массой путем хроматографии на гидроксиапатитах
NZ565173A (en) *	2005-07-25	2012-01-12	Emergent Product Dev Seattle	Single dose use of CD20 scFv for rheumatoid arthritis
BRPI0716597A2 (pt)	2006-09-08	2013-10-08	Wyeth Corp	Método para o isolamento de um produto; produto preparado pelo método; método para o isolamento de um anticorpo; método para reduzir a turvação de um eluído compreendendo em produto; e método para reduzir a turvação e impurezas de um eluído compreendendo um produto
AU2007308145A1 (en) *	2006-10-12	2008-04-17	Wyeth	Modification of ionic strength in antibody-solutions to reduce opalescence/aggregates
US7846434B2 (en) *	2006-10-24	2010-12-07	Trubion Pharmaceuticals, Inc.	Materials and methods for improved immunoglycoproteins
CN101842389A (zh)	2007-06-12	2010-09-22	惠氏有限责任公司	抗cd20治疗组合物和方法
AU2009314311B2 (en) *	2008-10-29	2013-01-10	Ablynx N.V.	Methods for purification of single domain antigen binding molecules

2010
- 2010-03-11 BR BRPI1009447A patent/BRPI1009447A2/pt not_active IP Right Cessation
- 2010-03-11 US US13/255,650 patent/US20120141497A1/en not_active Abandoned
- 2010-03-11 WO PCT/US2010/026931 patent/WO2010147686A2/en active Application Filing
- 2010-03-11 EP EP10755014A patent/EP2406274A2/en not_active Withdrawn
- 2010-03-11 AU AU2010260476A patent/AU2010260476A1/en not_active Abandoned
- 2010-03-11 KR KR1020117021247A patent/KR20110139216A/ko not_active Application Discontinuation
- 2010-03-11 CN CN2010800115236A patent/CN102395597A/zh active Pending
- 2010-03-11 JP JP2010054170A patent/JP2010209068A/ja not_active Withdrawn
- 2010-03-11 CA CA2751000A patent/CA2751000A1/en not_active Abandoned
- 2010-03-11 RU RU2011137030/10A patent/RU2011137030A/ru unknown
2011
- 2011-09-11 IL IL215082A patent/IL215082A0/en unknown

Also Published As

Publication number	Publication date
CA2751000A1 (en)	2010-12-23
KR20110139216A (ko)	2011-12-28
IL215082A0 (en)	2011-11-30
EP2406274A2 (en)	2012-01-18
JP2010209068A (ja)	2010-09-24
US20120141497A1 (en)	2012-06-07
WO2010147686A3 (en)	2011-02-24
CN102395597A (zh)	2012-03-28
RU2011137030A (ru)	2013-04-20
AU2010260476A1 (en)	2011-10-13
WO2010147686A2 (en)	2010-12-23

Publication	Publication Date	Title
BRPI1009447A2 (pt)	2016-03-01	métodos de purificação de proteínas imunofarmacêuticas modulares pequenas
HK1246330A1 (zh)	2018-09-07	蛋白質純化
HRP20181357T1 (hr)	2018-10-19	Novi postupci pročišćavanja proteina
BRPI1012605A2 (pt)	2016-03-22	método de limpeza
SMT201500142B (it)	2015-09-07	Procedimento per la purificazione di proteine
BR112012005146A2 (pt)	2018-01-23	fotobiorreator
BRPI1015220A2 (pt)	2016-10-25	purificador de água
EP2519536A4 (en)	2013-06-05	PROTEIN PURIFICATION BY ION EXCHANGE
DK2307543T3 (da)	2015-08-31	Forbedret proteinekspressionssystem
DK2273004T3 (da)	2013-03-18	Rensesystem
BR112012004402A2 (pt)	2016-11-16	glicosilação de proteína
BR212012009026U2 (pt)	2015-11-17	escova de dentes
BRPI1009018A2 (pt)	2015-12-01	fotobiorreator
EP2519537A4 (en)	2013-07-10	CLEANING PROTEINS
BRPI0922716A2 (pt)	2016-11-01	purificação de polipeptídeo
FI20105919A0 (fi)	2010-08-31	Menetelmä veden puhdistamiseksi
BRPI1010121A2 (pt)	2017-01-31	método de tratamento biológico
BRPI1015272A2 (pt)	2015-08-25	Fermentação
FR2946103B1 (fr)	2013-03-01	Support modulaire
IL229383A0 (en)	2014-01-30	A process for purifying protein with a low acidity level
FI20096202A0 (fi)	2009-11-19	Biologinen regeneraatti
BRPI0920524A2 (pt)	2015-12-22	método de purificação
BRPI1006155A2 (pt)	2016-02-23	purificador de água
DK2424661T3 (da)	2021-03-08	Zeolit y
FI20095795A0 (fi)	2009-07-17	Menetelmä biologiseen puhdistamiseen

Legal Events

Date	Code	Title	Description
2016-09-13	B08F	Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]	Free format text: REFERENTE AS 4A, 5A E 6A ANUIDADES.
2017-01-10	B08K	Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]	Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2384 DE 13-09-2016 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.
2021-06-01	B350	Update of information on the portal [chapter 15.35 patent gazette]