BRPI0716477A2 - Derivados heteroarila como inibidores de quinase protéica - Google Patents

Derivados heteroarila como inibidores de quinase protéica

Info

Publication number: BRPI0716477A2
Authority: BR; Brazil
Prior art keywords: heteroaril; derivatives; protein kinase; kinase inhibitors; inhibitors
Prior art date: 2006-09-06

Application number

BRPI0716477-7A2A

Other languages

English (en)

Inventor

Konrad Honold

Wolfgang Schaefer

Stefan Scheiblich

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-09-06

Filing date

2007-09-04

Publication date

2014-03-18

2007-09-04 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2014-03-18 Publication of BRPI0716477A2 publication Critical patent/BRPI0716477A2/pt

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Pain & Pain Management (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Rheumatology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

BRPI0716477-7A2A 2006-09-06 2007-09-04 Derivados heteroarila como inibidores de quinase protéica BRPI0716477A2 (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP06018627		2006-09-06
PCT/EP2007/007691 WO2008028617A1 (en)	2006-09-06	2007-09-04	Heteroaryl derivatives as protein kinase inhibitors

Publications (1)

Publication Number	Publication Date
BRPI0716477A2 true BRPI0716477A2 (pt)	2014-03-18

Family

ID=37668072

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI0716477-7A2A BRPI0716477A2 (pt)	2006-09-06	2007-09-04	Derivados heteroarila como inibidores de quinase protéica

Country Status (11)

Country	Link
US (1)	US8067599B2 (pt)
EP (1)	EP2064213A1 (pt)
JP (1)	JP2010502660A (pt)
KR (1)	KR101104666B1 (pt)
CN (1)	CN101511828A (pt)
AU (1)	AU2007294149A1 (pt)
BR (1)	BRPI0716477A2 (pt)
CA (1)	CA2662031A1 (pt)
IL (1)	IL196554A0 (pt)
MX (1)	MX2009002010A (pt)
WO (1)	WO2008028617A1 (pt)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU2007294149A1 (en)	2006-09-06	2008-03-13	F. Hoffmann-La Roche Ag	Heteroaryl derivatives as protein kinase inhibitors
WO2008144253A1 (en) *	2007-05-14	2008-11-27	Irm Llc	Protein kinase inhibitors and methods for using thereof
EP2265608A2 (en)	2008-02-29	2010-12-29	Array Biopharma, Inc.	Raf inhibitor compounds and methods of use thereof
JP2011513332A (ja)	2008-02-29	2011-04-28	アレイバイオファーマ、インコーポレイテッド	癌の治療のためのｒａｆ阻害剤としてのｎ−（６−アミノピリジン−３−イル）−３−（スルホンアミド）ベンズアミド誘導体
ES2400202T3 (es)	2008-02-29	2013-04-08	Array Biopharma, Inc.	Inhibidores de RAF de pirazol[3,4-B]piridina
EP2265609B1 (en) *	2008-02-29	2012-09-05	Array Biopharma, Inc.	Imdizo [4. 5-b] pyridine derivatives used as raf inhibitors
KR100970670B1 (ko)	2008-04-22	2010-07-15	계명대학교 산학협력단	세포증식 억제제로서 유용한 벤즈아미드 유도체 및 그제조방법
FR2941948B1 (fr) *	2009-02-12	2013-04-05	Nova Decision	Derives d'azaindoles en tant qu'inhibiteur des proteines kinases abl et src
EP2470532A1 (en) *	2009-08-28	2012-07-04	Array Biopharma, Inc.	1h-pyrazolo [ 3, 4-b]pyridine compounds for inhibiting raf kinase
WO2011025940A1 (en)	2009-08-28	2011-03-03	Array Biopharma Inc.	Raf inhibitor compounds and methods of use thereof
JP2013503190A (ja)	2009-08-28	2013-01-31	アレイバイオファーマ、インコーポレイテッド	Ｒａｆ阻害化合物およびその使用方法
CN102858754A (zh)	2009-08-28	2013-01-02	阵列生物制药公司	Raf抑制剂化合物及其使用方法
JP2013503193A (ja)	2009-08-28	2013-01-31	ジェネンテック，インコーポレイテッド	Ｒａｆ阻害剤化合物およびその使用方法
CA2771893A1 (en) *	2009-08-28	2011-03-03	Array Biopharma Inc.	Raf inhibitor compounds and methods of use thereof
US8883819B2 (en) *	2011-09-01	2014-11-11	Irm Llc	Bicyclic heterocycle derivatives for the treatment of pulmonary arterial hypertension
FR2984325A1 (fr) *	2011-12-14	2013-06-21	Sanofi Sa	Derives de pyrazolopyridine, leur procede de preparation et leur application en therapeutique
US10138235B2 (en)	2011-12-14	2018-11-27	Sanofi	Pyrazolopyridine derivatives, preparation process therefor and therapeutic use thereof
ES2588775T3 (es)	2011-12-31	2016-11-04	Beigene, Ltd.	Compuestos tricíclicos fusionados como inhibidores de cinasa raf
CN102659778A (zh) *	2012-03-22	2012-09-12	盛世泰科生物医药技术(苏州)有限公司	6-氨基-2-甲基-3H-咪唑并[4,5-b]吡啶的合成新工艺
FR3000493A1 (fr) *	2012-12-28	2014-07-04	Oribase Pharma	Nouveaux inhibiteurs de proteines kinases
FR3000492B1 (fr) *	2012-12-28	2015-09-11	Oribase Pharma	Nouveaux derives azaindole en tant qu'inhibiteurs multikinases
FR3000494B1 (fr) *	2012-12-28	2015-08-21	Oribase Pharma	Nouveaux derives d'azaindoles en tant qu'inhibiteurs de proteines kinases
JP6423372B2 (ja)	2013-02-28	2018-11-14	ブリストル−マイヤーズスクイブカンパニーＢｒｉｓｔｏｌ−ＭｙｅｒｓＳｑｕｉｂｂＣｏｍｐａｎｙ	強力なｒｏｃｋ１およびｒｏｃｋ２阻害剤としてのフェニルピラゾール誘導体
TW201444798A (zh)	2013-02-28	2014-12-01	必治妥美雅史谷比公司	作爲強效ｒｏｃｋ１及ｒｏｃｋ２抑制劑之苯基吡唑衍生物
MX362582B (es)	2013-06-28	2019-01-24	Beigene Ltd	Compuestos triciclicos fusionados de urea como inhibidores de raf quinasa y/o dimero de raf quinasa.
JP6380862B2 (ja)	2013-06-28	2018-08-29	ベイジーンリミテッド	複数種類のキナーゼの阻害剤としての縮合三環式アミド系化合物
AU2016249814B2 (en)	2015-04-17	2019-03-07	Corteva Agriscience Llc	Molecules having pesticidal utility, and intermediates, composition, and processes, related thereto
CN108701171B (zh) *	2015-10-22	2022-06-10	马古苏托科技大学	在通过抑制cyp17a1和cyp19a1治疗癌症中具有应用的药效团、化合物和方法
TWI758313B (zh)	2016-10-12	2022-03-21	美商陶氏農業科學公司	一種用於製備(1r,3r)-及(1s,3s)-2,2-二鹵基-3-(經取代之苯基)環丙烷甲酸的方法
RU2021133039A (ru)	2016-10-12	2021-12-02	ДАУ АГРОСАЙЕНСИЗ ЭлЭлСи	Молекулы, применимые в качестве пестицидов, и связанные с ними промежуточные продукты, композиции и способы
WO2019162458A1 (en) *	2018-02-23	2019-08-29	Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V.	Novel inhibitors of bacterial glutaminyl cyclases for use in the treatment of periodontal and related diseases

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1294713A2 (en) *	2000-06-27	2003-03-26	Genelabs Technologies, Inc.	Compounds possessing antibacterial, antifungal or antitumor activity
TWI276631B (en)	2002-09-12	2007-03-21	Avanir Pharmaceuticals	Phenyl-aza-benzimidazole compounds for modulating IgE and inhibiting cellular proliferation
GB0330043D0 (en)	2003-12-24	2004-01-28	Pharmacia Italia Spa	Pyrrolo [2,3-b] pyridine derivatives active as kinase inhibitors process for their preparation and pharmaceutical compositions comprising them
WO2006066914A2 (en)	2004-12-23	2006-06-29	F. Hoffmann-La Roche Ag	Carbamate substituted imidazo- and pyrrolo-pyridines as protein kinase inhibitors
CN101087787A (zh) *	2004-12-23	2007-12-12	霍夫曼-拉罗奇有限公司	苯甲酰胺衍生物，它们的制备及作为药剂的应用
ATE499372T1 (de) *	2005-07-29	2011-03-15	Hoffmann La Roche	Azabenzimidalzolderivate, ihre herstellung und ihre verwendung als antikrebsmittel
AU2007294149A1 (en)	2006-09-06	2008-03-13	F. Hoffmann-La Roche Ag	Heteroaryl derivatives as protein kinase inhibitors

2007
- 2007-09-04 AU AU2007294149A patent/AU2007294149A1/en not_active Abandoned
- 2007-09-04 CN CNA2007800326413A patent/CN101511828A/zh active Pending
- 2007-09-04 CA CA002662031A patent/CA2662031A1/en not_active Abandoned
- 2007-09-04 KR KR1020097004677A patent/KR101104666B1/ko not_active IP Right Cessation
- 2007-09-04 MX MX2009002010A patent/MX2009002010A/es active IP Right Grant
- 2007-09-04 EP EP07802106A patent/EP2064213A1/en not_active Withdrawn
- 2007-09-04 BR BRPI0716477-7A2A patent/BRPI0716477A2/pt not_active IP Right Cessation
- 2007-09-04 US US12/374,682 patent/US8067599B2/en not_active Expired - Fee Related
- 2007-09-04 JP JP2009527045A patent/JP2010502660A/ja active Pending
- 2007-09-04 WO PCT/EP2007/007691 patent/WO2008028617A1/en active Application Filing
2009
- 2009-01-15 IL IL196554A patent/IL196554A0/en unknown

Also Published As

Publication number	Publication date
CA2662031A1 (en)	2008-03-13
US20090318428A1 (en)	2009-12-24
IL196554A0 (en)	2009-11-18
CN101511828A (zh)	2009-08-19
EP2064213A1 (en)	2009-06-03
JP2010502660A (ja)	2010-01-28
KR101104666B1 (ko)	2012-01-13
MX2009002010A (es)	2009-03-05
WO2008028617A1 (en)	2008-03-13
KR20090038487A (ko)	2009-04-20
US8067599B2 (en)	2011-11-29
AU2007294149A1 (en)	2008-03-13

Publication	Publication Date	Title
BRPI0716477A2 (pt)	2014-03-18	Derivados heteroarila como inibidores de quinase protéica
CY2019009I2 (el)	2019-11-27	Αναστολεις πρωτεϊνικων κινασων
BRPI0719991A2 (pt)	2014-03-18	Derivados de di-hidropiridina úteis como inibidores de proteína cinase
BRPI0910668A2 (pt)	2019-09-24	inibidores de proteína quinases
BRPI0719797A2 (pt)	2017-10-24	compostos e composições como inibidores de proteína cinase
ATE479434T1 (de)	2010-09-15	Als protein-kinase-inhibitoren nutzbare dyhydrodiazepine
BRPI0911228A2 (pt)	2017-05-30	compostos e composições como inibidores de proteínas quinase
BRPI0918846A2 (pt)	2019-09-24	inibidores de cinase heterocíclica
BRPI0920239A2 (pt)	2019-09-24	compostos heterocíclicos como inibidores de proteínas quinases
BRPI0820544A2 (pt)	2015-06-16	4-pirazolil-n-arilpirimidin-2-aminas e pirazolil-n-heteroarilpirimidin-2-aminas como inibidores de janus cinase
BRPI0714291A2 (pt)	2014-10-21	Derivados de [4,5']bipirimidinil-6-4'-diamina como inibidores de proteína cinase
BRPI0913879A2 (pt)	2019-09-24	fenilpirazinonas como inibidores de quinase
BRPI0811065A2 (pt)	2014-12-02	Indazóis 5-heteroaril substituídos como inibidores de quinase
ATE475662T1 (de)	2010-08-15	Dihydropyrazolopyrimidinonderivate
BRPI0920135A2 (pt)	2019-09-24	imidazopiridazinacarbonitrilos úteis como inibidores de quinase
ATE483711T1 (de)	2010-10-15	Spiroindolinonderivate
BRPI0716781A2 (pt)	2014-11-18	Inibidores da quinase
ATE488505T1 (de)	2010-12-15	Kinasehemmer auf hydantoinbasis
ATE469905T1 (de)	2010-06-15	Pyridopyrimidinonderivate
ATE512135T1 (de)	2011-06-15	Spiroindolinonderivate
ATE506358T1 (de)	2011-05-15	2-benzylpyridazinonderivate als met-kinasehemmer
DK2035394T3 (da)	2009-10-05	2-pyrazincarboxamidderivater
BRPI0719389A2 (pt)	2014-10-07	Derivados de hidantoína utilizados como inibidores de mmp
CR10879A (es)	2009-08-05	Cyclized derivatives as eg-5 inhibitors
BRPI0720547A2 (pt)	2014-05-06	Inibidores de metaloprotease derivada de heterocíclico

Legal Events

Date	Code	Title	Description
2014-08-26	B08L	Patent application lapsed because of non payment of annual fee [chapter 8.12 patent gazette]	Free format text: REFERENTE AO NAO RECOLHIMENTO DAS 6A E 7A ANUIDADES.
2020-11-10	B08I	Publication cancelled [chapter 8.9 patent gazette]	Free format text: ANULADA A PUBLICACAO CODIGO 8.12 NA RPI NO 2277 DE 26/08/2014 POR TER SIDO INDEVIDA.
2020-11-17	B08F	Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]	Free format text: REFERENTE AS 6A, 7A, 8A, 9A, 10A, 11A, 12A E 13A ANUIDADES.
2021-03-09	B08K	Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]	Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2602 DE 17-11-2020 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.