Nothing Special   »   [go: up one dir, main page]

BRPI0610644B8 - composto e composição farmacêutica que compreende tal composto e um veículo ou diluente farmaceuticamente aceitável. - Google Patents

composto e composição farmacêutica que compreende tal composto e um veículo ou diluente farmaceuticamente aceitável.

Info

Publication number
BRPI0610644B8
BRPI0610644B8 BRPI0610644A BRPI0610644A BRPI0610644B8 BR PI0610644 B8 BRPI0610644 B8 BR PI0610644B8 BR PI0610644 A BRPI0610644 A BR PI0610644A BR PI0610644 A BRPI0610644 A BR PI0610644A BR PI0610644 B8 BRPI0610644 B8 BR PI0610644B8
Authority
BR
Brazil
Prior art keywords
compound
diluent
pharmaceutically acceptable
pharmaceutical composition
acceptable carrier
Prior art date
Application number
BRPI0610644A
Other languages
English (en)
Inventor
J Bergeron Raymond
Original Assignee
Univ Florida
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36676582&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0610644(B8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Univ Florida filed Critical Univ Florida
Publication of BRPI0610644A2 publication Critical patent/BRPI0610644A2/pt
Publication of BRPI0610644B1 publication Critical patent/BRPI0610644B1/pt
Publication of BRPI0610644B8 publication Critical patent/BRPI0610644B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/04—Chelating agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D277/10—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Obesity (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

composto, composição farmacêutica que compreende um carreador ou diluente farmaceuticamente aceitável e o composto, método de tratamento de uma condição patológica, método para reduzir estresse oxidante, método de tratamento de um paciente que padece de enfermidade neoplástica ou uma condição pré-neoplástica. compostos representados pela fórmula estrutural descrita neste contexto, tal como a fórmula estrutural (i), são de utilidade no tratamento de condições tais como sobrecarga de metal, estresse oxidante, e condições neoplásticas e pré-neoplásticas.
BRPI0610644A 2005-04-04 2006-03-22 composto e composição farmacêutica que compreende tal composto e um veículo ou diluente farmaceuticamente aceitável. BRPI0610644B8 (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US66804505P 2005-04-04 2005-04-04
US60/668,045 2005-04-04
US60/668,05 2005-04-04
PCT/US2006/010945 WO2006107626A1 (en) 2005-04-04 2006-03-22 Desferrithiocin polyether analogues

Publications (3)

Publication Number Publication Date
BRPI0610644A2 BRPI0610644A2 (pt) 2010-07-13
BRPI0610644B1 BRPI0610644B1 (pt) 2020-09-29
BRPI0610644B8 true BRPI0610644B8 (pt) 2021-05-25

Family

ID=36676582

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0610644A BRPI0610644B8 (pt) 2005-04-04 2006-03-22 composto e composição farmacêutica que compreende tal composto e um veículo ou diluente farmaceuticamente aceitável.

Country Status (14)

Country Link
US (6) US8278458B2 (pt)
EP (2) EP1866296B1 (pt)
JP (3) JP5202299B2 (pt)
CN (1) CN101189216B (pt)
AU (1) AU2006232929B9 (pt)
BR (1) BRPI0610644B8 (pt)
CA (1) CA2603385C (pt)
CY (1) CY1119002T1 (pt)
DK (2) DK1866296T3 (pt)
ES (2) ES2614086T3 (pt)
MX (1) MX2007012226A (pt)
PL (2) PL3190106T3 (pt)
TR (1) TR201910900T4 (pt)
WO (1) WO2006107626A1 (pt)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6083966A (en) 1998-08-31 2000-07-04 University Of Florida Thiazoline acid derivatives
AU2003270473A1 (en) 2003-09-09 2005-04-27 University Of Florida Desferrithiocin derivatives and their use as iron chelators
DK1866296T3 (en) 2005-04-04 2017-02-13 Univ Florida DESFERRITHIOCINPOLYETHER-ANALOGS
WO2008130395A2 (en) * 2006-12-12 2008-10-30 University Of Florida Desferrithiocin analogue actinide decorporation agents
US8324397B2 (en) * 2007-03-15 2012-12-04 University Of Florida Research Foundation, Inc. Desferrithiocin polyether analogues
MX2011000486A (es) * 2008-07-14 2011-08-03 Ferrokin Biosciences Inc Nuevas sales y polimorfos de análogos de desazadesferritiocin polieter como agentes de quelacion metálicos.
EP2459544A4 (en) * 2009-07-27 2012-12-05 Ferrokin Biosciences Inc DESDAADESFERROTHIOCIN POLYETHERAL ANALOGUE PROGRUGS USING METAL CHLORIDE
CN102574824B (zh) * 2009-08-25 2016-04-27 佛罗里达大学研究基金会 去铁硫辛聚醚类似物及其用途
US20130053387A1 (en) * 2010-05-04 2013-02-28 FerroKin BioScience, Inc. Desazadesferrothiocin and desazadesferrothiocin polyether analogues as metal chelation agents
AR089122A1 (es) 2011-12-09 2014-07-30 Ferrokin Biosciences Inc Formulaciones orales para tratar la sobrecarga de metales
EP2790697B1 (en) 2011-12-16 2019-10-23 University of Florida Research Foundation, Inc. Uses of 4'-desferrithiocin analogs
US9512095B2 (en) 2013-03-15 2016-12-06 Ferrokin Biosciences, Inc. Polymorph forms of desazadesferrithiocin analogs
EP3071201A4 (en) * 2013-11-22 2017-04-26 University of Florida Research Foundation, Inc. Desferrithiocin analogs and uses thereof
SG11201610906XA (en) * 2014-07-18 2017-02-27 Applied Materials Inc Additive manufacturing with laser and plasma
EP3288557A4 (en) * 2015-04-27 2018-11-07 University of Florida Research Foundation, Inc. Metabolically programmed metal chelators and uses thereof
US10982136B2 (en) 2016-02-26 2021-04-20 The Regents Of The University Of California Ligand-sensitized lanthanide nanocrystals as ultraviolet downconverters
KR102480882B1 (ko) 2016-08-05 2022-12-26 아브페로 파마슈티칼스, 인크. 금속-매개 상태를 치료하기 위한 투여 요법
WO2018044812A2 (en) 2016-08-29 2018-03-08 Fred Hutchinson Cancer Research Center Chelating platform for delivery of radionuclides
CA3035966A1 (en) 2016-09-06 2018-03-15 The Regents Of The University Of California Formulations of hydroxypyridonate actinide/lanthanide decorporation agents
EP3520117B1 (en) 2016-09-29 2023-11-08 The Regents of The University of California Separation of metal ions by liquid-liquid extraction

Family Cites Families (94)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3274207A (en) 1966-09-20 Processes for preparing thiazole carboxylic acids
US3809754A (en) 1968-12-31 1974-05-07 Medial De Toledo & Cie Method of treating diseases of the mucous membrane using compounds of a thiazolidine carboxylic acid and pharmaceutical preparations thereof
US3882110A (en) 1969-06-11 1975-05-06 Roussel Uclaf Novel 2-alkyl-5-thiazole-carboxylic acid derivatives
IT1050117B (it) 1969-09-17 1981-03-10 Godo Shusei Kk Metodo per la sintesi dell acido aeruginoico
FR2062120A5 (pt) 1969-10-10 1971-06-25 Messier Fa
FR2141526B1 (pt) 1971-06-14 1975-05-30 Roussel Uclaf
DE2245560A1 (de) 1972-09-16 1974-03-21 Basf Ag Verfahren zur herstellung von 4alkoxycarbonyl-2-thiazolinen
AU528115B2 (en) 1978-04-08 1983-04-14 Santen Pharmaceutical Co. Ltd. Antihypertensive 4-thiazolidine/carboxylic acids
CS205217B1 (cs) 1979-04-05 1981-05-29 Zdenek Vitamvas Dozimetr ionizujícího záření
US4270537A (en) 1979-11-19 1981-06-02 Romaine Richard A Automatic hypodermic syringe
DE3002989A1 (de) 1980-01-29 1981-07-30 Hoechst Ag, 6000 Frankfurt Hydroxyphenyl-thiazol, -thiazolin und -thiazolidin-carbonsaeuren, verfahren zu ihrer herstellung und ihre verwendung zur beeinflussung des kollagenstoffwechsels
JPS5758682A (en) 1980-07-28 1982-04-08 Ciba Geigy Ag Thiazoline derivatives, manufacture and medicinal composition containing same
DE3170401D1 (en) 1980-07-28 1985-06-13 Ciba Geigy Ag Triazoline derivatives and processes for their preparation
JPS5772975A (en) 1980-10-24 1982-05-07 Kureha Chem Ind Co Ltd 2-substituted phenylthiazole derviative, and medicine for peptic ulcer containing said derivative as active component
US4367233A (en) 1981-10-02 1983-01-04 American Home Products Corporation Inhibitors of mammalian collagenase
DE3586683T2 (de) 1984-12-18 1993-04-08 Clark Pharma Dev Antitumorzusammensetzungen enthaltend ein reaktionsprodukt zwischen einem cytotoxischen aldehyd und penicillamin und deren verwendung zur herstellung von arzneimitteln.
US4596556A (en) 1985-03-25 1986-06-24 Bioject, Inc. Hypodermic injection apparatus
HU200177B (en) 1985-06-18 1990-04-28 Biogal Gyogyszergyar Process for producing thiazolidinecarboxylic acids and pharmaceutical compositions comprising such compounds
US4736060A (en) 1985-08-06 1988-04-05 Nippon Rikagakuyakuhin Co., Ltd. Method for optical resolution of DL-cysteine and (R,S)-1-(1-naphthyl) ethylamine
EP0214933A3 (de) 1985-09-03 1989-05-24 Ciba-Geigy Ag Kombinationspräparate zur Behandlung von Malaria
EP0214101A3 (de) 1985-09-03 1989-05-31 Ciba-Geigy Ag Verwendung von Eisen(III)-Chelatoren vom Typ Desferrioxamin B und Desferriferrithiocin zur Behandlung von Malaria
JPS62142168A (ja) 1985-10-16 1987-06-25 Mitsubishi Chem Ind Ltd チアゾ−ル誘導体及びそれを有効成分とするロイコトリエンきつ抗剤
DE3621540A1 (de) 1986-06-27 1988-01-07 Basf Ag Chinolinderivate, verfahren zu ihrer herstellung, diese enthaltende mikrobizide und ihre verwendung zur bekaempfung von bakterien und pilzen
CA1283827C (en) 1986-12-18 1991-05-07 Giorgio Cirelli Appliance for injection of liquid formulations
GB8704027D0 (en) 1987-02-20 1987-03-25 Owen Mumford Ltd Syringe needle combination
US4790824A (en) 1987-06-19 1988-12-13 Bioject, Inc. Non-invasive hypodermic injection device
US4940460A (en) 1987-06-19 1990-07-10 Bioject, Inc. Patient-fillable and non-invasive hypodermic injection device assembly
US4941880A (en) 1987-06-19 1990-07-17 Bioject, Inc. Pre-filled ampule and non-invasive hypodermic injection device assembly
DE3735757A1 (de) 1987-10-22 1989-05-03 Degussa Optisch aktive salze aus einem substituierten thiazolidin-4-carboxylat und 3-chlor-2-hydroxypropyltrimethylammonium, deren herstellung und verwendung
EP0325559B1 (de) 1988-01-20 1993-12-15 Ciba-Geigy Ag Verfahren zur Herstellung von Komplexverbindungen
US5339163A (en) 1988-03-16 1994-08-16 Canon Kabushiki Kaisha Automatic exposure control device using plural image plane detection areas
FR2638359A1 (fr) 1988-11-03 1990-05-04 Tino Dalto Guide de seringue avec reglage de la profondeur de penetration de l'aiguille dans la peau
GB8826035D0 (en) 1988-11-07 1988-12-14 Ici Plc Herbicidal compositions
US5182402A (en) 1988-11-07 1993-01-26 Imperial Chemical Industries Plc Herbicidal compositions
US5106992A (en) 1989-07-28 1992-04-21 E. R. Squibb & Sons, Inc. 3,5-dihydroxypentanoic acid derivatives useful as antihypercholesterolemic agents and method for preparing same
US5312335A (en) 1989-11-09 1994-05-17 Bioject Inc. Needleless hypodermic injection device
US5064413A (en) 1989-11-09 1991-11-12 Bioject, Inc. Needleless hypodermic injection device
US5190521A (en) 1990-08-22 1993-03-02 Tecnol Medical Products, Inc. Apparatus and method for raising a skin wheal and anesthetizing skin
NL9001955A (nl) 1990-09-05 1992-04-01 Cedona Pharm Bv Nieuwe thiazolidinederivaten.
US5393777A (en) 1990-11-15 1995-02-28 State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Oregon Health Sciences University Deferration using anguibactin siderophore
CA2074933C (en) 1990-11-30 2002-12-03 Masatoshi Chihiro Thiazole derivatives as active superoxide radical inhibitors
ES2092580T3 (es) 1990-11-30 1996-12-01 Teijin Ltd Derivado de 2-ariltiazol y composicion farmaceutica que contiene el mismo.
US5527288A (en) 1990-12-13 1996-06-18 Elan Medical Technologies Limited Intradermal drug delivery device and method for intradermal delivery of drugs
FR2677021B1 (fr) 1991-05-31 1993-10-01 Upsa Laboratoires Nouveaux derives de thiazole antagonistes des recepteurs a l'angiotensine ii; leurs procedes de preparation, compositions pharmaceutiques les contenant.
GB9118204D0 (en) 1991-08-23 1991-10-09 Weston Terence E Needle-less injector
SE9102652D0 (sv) 1991-09-13 1991-09-13 Kabi Pharmacia Ab Injection needle arrangement
US5328483A (en) 1992-02-27 1994-07-12 Jacoby Richard M Intradermal injection device with medication and needle guard
US5383851A (en) 1992-07-24 1995-01-24 Bioject Inc. Needleless hypodermic injection device
US5569189A (en) 1992-09-28 1996-10-29 Equidyne Systems, Inc. hypodermic jet injector
US5334144A (en) 1992-10-30 1994-08-02 Becton, Dickinson And Company Single use disposable needleless injector
US5840739A (en) 1992-11-16 1998-11-24 University Of Florida Research Foundation, Inc. Thiazoline acid derivatives
AU5602594A (en) 1992-11-16 1994-06-08 University Of Florida Research Foundation, Inc. 2-(pyrid-2'-yl)-2-thiazoline-4(s)-carboxylic acid derivatives
DE4301356A1 (de) 1993-01-20 1994-07-21 Basf Ag Verfahren zur Herstellung von 2-Alkyl-4-fluormethyl-thiazolcarbonsäure-alkylestern
WO1995024176A1 (en) 1994-03-07 1995-09-14 Bioject, Inc. Ampule filling device
US5466220A (en) 1994-03-08 1995-11-14 Bioject, Inc. Drug vial mixing and transfer device
US5599302A (en) 1995-01-09 1997-02-04 Medi-Ject Corporation Medical injection system and method, gas spring thereof and launching device using gas spring
US5730723A (en) 1995-10-10 1998-03-24 Visionary Medical Products Corporation, Inc. Gas pressured needle-less injection device and method
US5893397A (en) 1996-01-12 1999-04-13 Bioject Inc. Medication vial/syringe liquid-transfer apparatus
GB9607549D0 (en) 1996-04-11 1996-06-12 Weston Medical Ltd Spring-powered dispensing device
FR2749583B1 (fr) 1996-06-07 1998-08-21 Lipha Nouveaux derives de thiazolidine -2,4- dione substitues, leurs procedes d'obtention et les compositions pharmaceutiques en renfermant
US20020049316A1 (en) 1997-04-29 2002-04-25 Halbert Stacie Marie Protease inhibitors
US5993412A (en) 1997-05-19 1999-11-30 Bioject, Inc. Injection apparatus
US6373912B1 (en) 1997-06-16 2002-04-16 Legerity, Inc. Phase-locked loop arrangement with fast lock mode
IT1298087B1 (it) 1998-01-08 1999-12-20 Fiderm S R L Dispositivo per il controllo della profondita' di penetrazione di un ago, in particolare applicabile ad una siringa per iniezioni
TR200002256T2 (tr) * 1998-02-04 2001-03-21 University Of Florida Research Foundation, Inc. Demir celatlama tedavisinde N,N' -BIS(2-Hidroksibenzil) etilendiamin-N, N'diasetik asit içeren farmasötikler.
MA26618A1 (fr) 1998-04-09 2004-12-20 Smithkline Beecham Corp Composes et compositions pharmaceutiques pour le traitement du paludisme
US6147070A (en) 1998-06-05 2000-11-14 Facchini; Francesco Methods and compositions for controlling iron stores to treat and cure disease states
US6083966A (en) 1998-08-31 2000-07-04 University Of Florida Thiazoline acid derivatives
US6159983A (en) 1998-09-18 2000-12-12 University Of Florida Method and composition for treatment of inflammatory bowel disease
AU774956B2 (en) 1998-09-21 2004-07-15 Trustees Of Columbia University In The City Of New York, The Antimalarial agents
US6251927B1 (en) 1999-04-20 2001-06-26 Medinox, Inc. Methods for treatment of sickle cell anemia
DE19948434A1 (de) 1999-10-08 2001-06-07 Gruenenthal Gmbh Substanzbibliothek enthaltend bicyclische Imidazo-5-amine und/oder bicyclische Imidazo-3-amine
US7160855B2 (en) 2002-03-14 2007-01-09 Children's Hospital & Research Center At Oakland Enhancement of iron chelation therapy
US20040044220A1 (en) 2002-08-22 2004-03-04 University Of Florida Antioxidant and radical scavenging activity of synthetic analogs of desferrithiocin
WO2004017959A2 (en) 2002-08-22 2004-03-04 University Of Florida Antioxidant and radical scavenging activity of synthetic analogs of desferrithiocin
EP1667727B1 (en) 2003-09-09 2008-07-09 University of Florida Research Foundation, Inc. Polyamine-metal chelator conjugates
AU2003270473A1 (en) 2003-09-09 2005-04-27 University Of Florida Desferrithiocin derivatives and their use as iron chelators
US20060128805A1 (en) 2004-11-19 2006-06-15 Shah Sudhir V Methods of treating erythropoietin-resistance
DK1866296T3 (en) 2005-04-04 2017-02-13 Univ Florida DESFERRITHIOCINPOLYETHER-ANALOGS
US20080194518A1 (en) 2005-12-23 2008-08-14 MOOKERJEE Pradip Antimicrobial Compositions
CN101129381B (zh) 2006-08-25 2012-02-01 天津和美生物技术有限公司 含β-内酰胺类抗生素和离子螯合剂的抗生素复方
WO2008130395A2 (en) 2006-12-12 2008-10-30 University Of Florida Desferrithiocin analogue actinide decorporation agents
US8324397B2 (en) 2007-03-15 2012-12-04 University Of Florida Research Foundation, Inc. Desferrithiocin polyether analogues
FR2922210A1 (fr) 2007-10-11 2009-04-17 Univ Louis Pasteur Etablisseme Nouveaux composes, preparation et utilisations
MX2011000486A (es) 2008-07-14 2011-08-03 Ferrokin Biosciences Inc Nuevas sales y polimorfos de análogos de desazadesferritiocin polieter como agentes de quelacion metálicos.
PL385765A1 (pl) 2008-07-28 2010-02-01 Maciej Żurek Sposób sterowania łopatą napędową względem kierunku wiatru, zwłaszcza w silniku wiatrowym i wodnym o osi prostopadłej do kierunku wiatru oraz silnik wiatrowy o osi prostopadłej do kierunku wiatru z łopatą napędową sterowaną względem kierunku wiatru
EP2459544A4 (en) 2009-07-27 2012-12-05 Ferrokin Biosciences Inc DESDAADESFERROTHIOCIN POLYETHERAL ANALOGUE PROGRUGS USING METAL CHLORIDE
CN102574824B (zh) 2009-08-25 2016-04-27 佛罗里达大学研究基金会 去铁硫辛聚醚类似物及其用途
US20130053387A1 (en) 2010-05-04 2013-02-28 FerroKin BioScience, Inc. Desazadesferrothiocin and desazadesferrothiocin polyether analogues as metal chelation agents
WO2012027794A2 (en) 2010-09-01 2012-03-08 The Mental Health Research Institute Of Victoria Method of treatment and agents useful for same
US20140323534A1 (en) 2011-12-16 2014-10-30 University Of Florida Research Foundation, Inc. Uses of 3'-desferrithiocin analogs
EP2790697B1 (en) 2011-12-16 2019-10-23 University of Florida Research Foundation, Inc. Uses of 4'-desferrithiocin analogs
WO2014134701A1 (en) 2013-03-07 2014-09-12 Kane Biotech Inc. Antimicrobial-antibiofilm compositions and methods of use thereof
EP3071201A4 (en) 2013-11-22 2017-04-26 University of Florida Research Foundation, Inc. Desferrithiocin analogs and uses thereof

Also Published As

Publication number Publication date
JP2012131814A (ja) 2012-07-12
US20170217912A1 (en) 2017-08-03
TR201910900T4 (tr) 2019-08-21
EP3190106B1 (en) 2019-05-08
CA2603385C (en) 2014-07-15
WO2006107626A1 (en) 2006-10-12
US9994535B2 (en) 2018-06-12
ES2614086T3 (es) 2017-05-29
US20140235680A1 (en) 2014-08-21
US9096553B2 (en) 2015-08-04
PL3190106T3 (pl) 2019-10-31
US8722899B2 (en) 2014-05-13
CA2603385A1 (en) 2006-10-12
JP6178816B2 (ja) 2017-08-09
EP1866296B1 (en) 2016-11-02
EP3190106A1 (en) 2017-07-12
US9567309B2 (en) 2017-02-14
JP2015145403A (ja) 2015-08-13
MX2007012226A (es) 2007-12-10
BRPI0610644B1 (pt) 2020-09-29
JP5771546B2 (ja) 2015-09-02
CN101189216A (zh) 2008-05-28
US20080214630A1 (en) 2008-09-04
JP5202299B2 (ja) 2013-06-05
EP1866296A1 (en) 2007-12-19
AU2006232929B9 (en) 2009-12-17
DK1866296T3 (en) 2017-02-13
BRPI0610644A2 (pt) 2010-07-13
US20130030028A1 (en) 2013-01-31
JP2008536833A (ja) 2008-09-11
PL1866296T3 (pl) 2017-05-31
US8278458B2 (en) 2012-10-02
US20150336911A1 (en) 2015-11-26
DK3190106T3 (da) 2019-07-15
CY1119002T1 (el) 2018-01-10
AU2006232929B2 (en) 2009-11-05
AU2006232929A1 (en) 2006-10-12
CN101189216B (zh) 2011-10-19
ES2732625T3 (es) 2019-11-25
US20180290990A1 (en) 2018-10-11

Similar Documents

Publication Publication Date Title
BRPI0610644B8 (pt) composto e composição farmacêutica que compreende tal composto e um veículo ou diluente farmaceuticamente aceitável.
ATE433447T1 (de) Pyrimiidinverbindungen
BRPI0607455A2 (pt) composto, processo para a preparação do mesmo, uso de um composto, e composição farmacêutica
SE0301010D0 (sv) Novel compounds
SE0301009D0 (sv) Novel compounds
DK1853602T3 (da) Kemiske forbindelser
NO20076059L (no) 2,4-Diamino-pyrimidiner anvendt som aurorainhibitorer
NO20072461L (no) Fremstilling og anvendelse av bifenyl-4-yl-karbonylaminosyre derivater for behandling av fedme
MY142589A (en) Benzimidazole derivatives : preparation and pharmaceutical applications
TW200716606A (en) Chemical compounds
TW200800963A (en) Chemical compounds
MX2007002398A (es) Nuevas composiciones farmaceuticas para el tratamiento de cancer.
WO2008013987A3 (en) N-alkyl substituted piperazinylmethylquinazolinones and azepanylmethylquinazolinones
WO2006089871A3 (en) Diphenylurea derivatives useful as erg channel openers for the treatment of cardiac arrhythmias
NO20064344L (no) Caspaseinhibitorer og anvendelser derav
WO2007076087A3 (en) 3-aryl-substituted quinazolones, and uses thereof
TW200716564A (en) Tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents
EA200600605A1 (ru) Перегруппированные пентанолы, способ их получения и их применение в качестве противовоспалительных средств
TW200738611A (en) 9-Chloro-15-deoxyprostaglandin derivatives, process for their preparation and their use as medicaments
NO20080839L (no) Isotopsubstituerte protonpumpeinhibitorer
PL1831239T3 (pl) Sposób wytwarzania gamma-laktonu kwasu 17-hydroksy-6 beta, 7 beta,15 beta, 16 beta-bismetyleno-17 alpha-pregn-4-en-3-ono-21-karboksylowego i związki pośrednie kluczowe dla tego sposobu
WO2006080043A3 (en) Organic compounds useful for the treatment of alzheimer's disease, their use and method of preparation
CA2585802A1 (en) Industrial process for the preparation of 17-hydroxy-6.beta.,7.beta.;15.beta.,16.beta.-bismethylene-3-oxo-17.alpha.pregn-4-ene-21-carboxylic acid.gamma.-lactone and key-intermediates for this process
WO2007059356A3 (en) Furfurylidene- pyrazolidines and their use as inhibitors of ubiquitin e1
TW200621703A (en) Alkylidene-tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents

Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07E Notice of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B06A Notification to applicant to reply to the report for non-patentability or inadequacy of the application [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 29/09/2020, OBSERVADAS AS CONDICOES LEGAIS.

B16C Correction of notification of the grant

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 22/03/2006 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF