BRPI9809391B8 - processo para a produção de um receptor de antígeno anti-humano, anticorpo humano e composição farmacêutica - Google Patents
processo para a produção de um receptor de antígeno anti-humano, anticorpo humano e composição farmacêuticaInfo
- Publication number
- BRPI9809391B8 BRPI9809391B8 BRPI9809391A BR9809391A BRPI9809391B8 BR PI9809391 B8 BRPI9809391 B8 BR PI9809391B8 BR PI9809391 A BRPI9809391 A BR PI9809391A BR 9809391 A BR9809391 A BR 9809391A BR PI9809391 B8 BRPI9809391 B8 BR PI9809391B8
- Authority
- BR
- Brazil
- Prior art keywords
- human
- receptors
- producing
- chains
- antigen
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 5
- 102000006306 Antigen Receptors Human genes 0.000 title abstract 3
- 108010083359 Antigen Receptors Proteins 0.000 title abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 102000005962 receptors Human genes 0.000 abstract 5
- 108020003175 receptors Proteins 0.000 abstract 5
- 239000000427 antigen Substances 0.000 abstract 4
- 102000036639 antigens Human genes 0.000 abstract 4
- 108091007433 antigens Proteins 0.000 abstract 4
- 241000282412 Homo Species 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 210000004027 cell Anatomy 0.000 abstract 2
- 230000002163 immunogen Effects 0.000 abstract 2
- 230000005847 immunogenicity Effects 0.000 abstract 2
- 101150084967 EPCAM gene Proteins 0.000 abstract 1
- 102000012745 Immunoglobulin Subunits Human genes 0.000 abstract 1
- 108010079585 Immunoglobulin Subunits Proteins 0.000 abstract 1
- 210000003719 b-lymphocyte Anatomy 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 229940127121 immunoconjugate Drugs 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Steroid Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
patente de invenção: <b>"processo para a produção de receptores de antígenos anti-humanos e usos dos mesmos"<d>. descreve-se um processo para produção de um receptor de antígeno anti-humano que é de baixa imunogenicidade ou não-imunogênico em seres humanos, compreendendo as etapas de seleção de uma combinação de cadeias de imunoglobulina vh e vl, em que pelo menos a dita cadeia vh é derivada de linfócitos b humanos maduros essencialmente não-iniciados ou de células b humanas essencialmente anérgicas e a dita cadeia vl é derivada de um repertório de células b humanas naturais, as ditas cadeias sendo expressadas a partir de um vetor recombinante e usando um sistema de exposição 'in vitro', para ligação em um antígeno de ser humano. além do mais, são proporcionados receptores que são de baixa imunogenicidade ou não-imunogênicos em seres humanos e direcionados para os antígenos de seres humanos, os ditos receptores sendo obtensíveis pelo processo da invenção. os ditos receptores são, de preferência, anticorpos ou fragmentos deles ou imunoconjugados compreendendo as cadeias vh/vl do dito anticorpo. em particular, os receptores são descritos direcionados para os antígenos de tumor de seres humanos, de preferência, para o antígeno 17-1a de tumor de ser humano, também conhecido como epcam, egp ou ga 733-2. finalmente, são proporcionados os kits úteis para a condução do processo da invenção e as composições farmacêuticas compreendendo os receptores mencionados acima.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP97106109 | 1997-04-14 | ||
| PCT/EP1998/002180 WO1998046645A2 (en) | 1997-04-14 | 1998-04-14 | Method for the production of antihuman antigen receptors and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BR9809391A BR9809391A (pt) | 2000-06-13 |
| BRPI9809391B1 BRPI9809391B1 (pt) | 2016-03-15 |
| BRPI9809391B8 true BRPI9809391B8 (pt) | 2021-05-25 |
Family
ID=8226694
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI9809391A BRPI9809391B8 (pt) | 1997-04-14 | 1998-04-14 | processo para a produção de um receptor de antígeno anti-humano, anticorpo humano e composição farmacêutica |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US7227002B1 (pt) |
| EP (1) | EP0970126B1 (pt) |
| JP (1) | JP3876002B2 (pt) |
| KR (2) | KR100516133B1 (pt) |
| CN (1) | CN100387621C (pt) |
| AT (1) | ATE200679T1 (pt) |
| AU (1) | AU742045B2 (pt) |
| BR (1) | BRPI9809391B8 (pt) |
| CA (1) | CA2286879C (pt) |
| CU (1) | CU23268A3 (pt) |
| CZ (1) | CZ294425B6 (pt) |
| DE (1) | DE69800716T2 (pt) |
| DK (1) | DK0970126T3 (pt) |
| ES (1) | ES2172149T3 (pt) |
| GR (1) | GR3036229T3 (pt) |
| HK (1) | HK1026911A1 (pt) |
| HU (1) | HU221818B1 (pt) |
| IL (2) | IL132062A0 (pt) |
| NO (1) | NO315904B1 (pt) |
| PL (1) | PL193780B1 (pt) |
| PT (1) | PT970126E (pt) |
| RU (1) | RU2224766C2 (pt) |
| SI (1) | SI0970126T1 (pt) |
| TR (1) | TR199902553T2 (pt) |
| WO (1) | WO1998046645A2 (pt) |
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| US6150584A (en) * | 1990-01-12 | 2000-11-21 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
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| EP0873363B1 (en) * | 1995-06-14 | 2010-10-06 | The Regents of The University of California | High affinity human antibodies to tumor antigens |
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