|
US348237A
(en)
*
|
|
1886-08-31 |
|
richards |
|
US73627A
(en)
*
|
|
1868-01-21 |
|
Improved paint-compound |
|
US4196265A
(en)
*
|
1977-06-15 |
1980-04-01 |
The Wistar Institute |
Method of producing antibodies
|
|
US4522811A
(en)
*
|
1982-07-08 |
1985-06-11 |
Syntex (U.S.A.) Inc. |
Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
|
|
US4469797A
(en)
*
|
1982-09-23 |
1984-09-04 |
Miles Laboratories, Inc. |
Digoxigenin immunogens, antibodies, labeled conjugates, and related derivatives
|
|
US4737462A
(en)
*
|
1982-10-19 |
1988-04-12 |
Cetus Corporation |
Structural genes, plasmids and transformed cells for producing cysteine depleted muteins of interferon-β
|
|
US4966843A
(en)
*
|
1982-11-01 |
1990-10-30 |
Cetus Corporation |
Expression of interferon genes in Chinese hamster ovary cells
|
|
US4816567A
(en)
*
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
|
KR850004274A
(ko)
|
1983-12-13 |
1985-07-11 |
원본미기재 |
에리트로포이에틴의 제조방법
|
|
US4703008A
(en)
|
1983-12-13 |
1987-10-27 |
Kiren-Amgen, Inc. |
DNA sequences encoding erythropoietin
|
|
NZ210501A
(en)
|
1983-12-13 |
1991-08-27 |
Kirin Amgen Inc |
Erythropoietin produced by procaryotic or eucaryotic expression of an exogenous dna sequence
|
|
US5082658A
(en)
*
|
1984-01-16 |
1992-01-21 |
Genentech, Inc. |
Gamma interferon-interleukin-2 synergism
|
|
EP0158198A1
(de)
|
1984-03-29 |
1985-10-16 |
Takeda Chemical Industries, Ltd. |
DNA und ihre Verwendung
|
|
US5807715A
(en)
*
|
1984-08-27 |
1998-09-15 |
The Board Of Trustees Of The Leland Stanford Junior University |
Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin
|
|
US4667016A
(en)
*
|
1985-06-20 |
1987-05-19 |
Kirin-Amgen, Inc. |
Erythropoietin purification
|
|
US4690915A
(en)
|
1985-08-08 |
1987-09-01 |
The United States Of America As Represented By The Department Of Health And Human Services |
Adoptive immunotherapy as a treatment modality in humans
|
|
US5679543A
(en)
*
|
1985-08-29 |
1997-10-21 |
Genencor International, Inc. |
DNA sequences, vectors and fusion polypeptides to increase secretion of desired polypeptides from filamentous fungi
|
|
US5643565A
(en)
*
|
1985-09-20 |
1997-07-01 |
Chiron Corporation |
Human IL-2 as a vaccine adjuvant
|
|
US4676980A
(en)
*
|
1985-09-23 |
1987-06-30 |
The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Target specific cross-linked heteroantibodies
|
|
US4935233A
(en)
*
|
1985-12-02 |
1990-06-19 |
G. D. Searle And Company |
Covalently linked polypeptide cell modulators
|
|
US5359035A
(en)
*
|
1985-12-21 |
1994-10-25 |
Hoechst Aktiengesellschaft |
Bifunctional proteins including interleukin-2 (IL-2) and granuloctyte macrophage colony stimulating factor (GM-CSF)
|
|
DE3712985A1
(de)
|
1987-04-16 |
1988-11-03 |
Hoechst Ag |
Bifunktionelle proteine
|
|
EP0237019A3
(de)
|
1986-03-14 |
1988-03-09 |
Toray Industries, Inc. |
Konjugiertes Interferon und dessen Herstellung unter Verwendung eines rekombinanten Gens
|
|
US5225539A
(en)
*
|
1986-03-27 |
1993-07-06 |
Medical Research Council |
Recombinant altered antibodies and methods of making altered antibodies
|
|
GB8607679D0
(en)
|
1986-03-27 |
1986-04-30 |
Winter G P |
Recombinant dna product
|
|
DK173067B1
(da)
|
1986-06-27 |
1999-12-13 |
Univ Washington |
Humant erythropoietin-gen, fremgangsmåde til ekspression deraf i transficerede cellelinier, de transficerede cellelinier sa
|
|
US4894227A
(en)
|
1986-08-01 |
1990-01-16 |
Cetus Corporation |
Composition of immunotoxins with interleukin-2
|
|
US4946778A
(en)
*
|
1987-09-21 |
1990-08-07 |
Genex Corporation |
Single polypeptide chain binding molecules
|
|
US5508031A
(en)
*
|
1986-11-21 |
1996-04-16 |
Cetus Oncology Corporation |
Method for treating biological damage using a free-radial scavenger and interleukin-2
|
|
US4732683A
(en)
*
|
1986-12-02 |
1988-03-22 |
Biospectrum, Inc. |
Purification method for alpha interferon
|
|
US5019368A
(en)
*
|
1989-02-23 |
1991-05-28 |
Cancer Biologics, Inc. |
Detection of necrotic malignant tissue and associated therapy
|
|
AU600575B2
(en)
*
|
1987-03-18 |
1990-08-16 |
Sb2, Inc. |
Altered antibodies
|
|
US5258498A
(en)
|
1987-05-21 |
1993-11-02 |
Creative Biomolecules, Inc. |
Polypeptide linkers for production of biosynthetic proteins
|
|
US5091513A
(en)
*
|
1987-05-21 |
1992-02-25 |
Creative Biomolecules, Inc. |
Biosynthetic antibody binding sites
|
|
ATE243754T1
(de)
|
1987-05-21 |
2003-07-15 |
Micromet Ag |
Multifunktionelle proteine mit vorbestimmter zielsetzung
|
|
DE3853740T2
(de)
|
1987-06-10 |
1995-11-09 |
Dana Farber Cancer Inst Inc |
Bifunktionelle Antikörperkonstruktionen und Verfahren zur selektiven Tötung von Zellbeständen.
|
|
US5064646A
(en)
|
1988-08-02 |
1991-11-12 |
The University Of Maryland |
Novel infectious bursal disease virus
|
|
PH26813A
(en)
|
1987-09-02 |
1992-11-05 |
Ciba Geigy Ag |
Conjugates of cytokines with immunoglobulins
|
|
DE3850542T2
(de)
|
1987-09-23 |
1994-11-24 |
Bristol Myers Squibb Co |
Antikörper-Heterokonjugate zur Töting von HIV-infizierten Zellen.
|
|
NZ226414A
(en)
|
1987-10-02 |
1992-07-28 |
Genentech Inc |
Cd4 peptide adhesion variants and their preparation and use
|
|
ZA888978B
(en)
|
1987-12-04 |
1990-07-25 |
Du Pont |
Immobilized interleukin 2 and interleukin 2 containing a carboxylterminal extension
|
|
WO1989006692A1
(en)
*
|
1988-01-12 |
1989-07-27 |
Genentech, Inc. |
Method of treating tumor cells by inhibiting growth factor receptor function
|
|
CA1341588C
(en)
|
1988-01-26 |
2009-01-06 |
Michel Revel |
Human ifn-beta2/i1-6, its purification and use
|
|
US5120525A
(en)
*
|
1988-03-29 |
1992-06-09 |
Immunomedics, Inc. |
Radiolabeled antibody cytotoxic therapy of cancer
|
|
US4975369A
(en)
*
|
1988-04-21 |
1990-12-04 |
Eli Lilly And Company |
Recombinant and chimeric KS1/4 antibodies directed against a human adenocarcinoma antigen
|
|
IT1217724B
(it)
|
1988-05-26 |
1990-03-30 |
Ist Naz Ric Sul Cancro |
Anticorpo monoclonale specifico per una sequenza di fibronettina espressa in cellule trasformate ibridoma secernente tale anticorpo e impiego dell'anticorpo monoclonale per la diagnosi di tumori
|
|
IE62463B1
(en)
|
1988-07-07 |
1995-02-08 |
Res Dev Foundation |
Immunoconjugates for cancer diagnosis and therapy
|
|
US5601819A
(en)
*
|
1988-08-11 |
1997-02-11 |
The General Hospital Corporation |
Bispecific antibodies for selective immune regulation and for selective immune cell binding
|
|
US5457038A
(en)
|
1988-11-10 |
1995-10-10 |
Genetics Institute, Inc. |
Natural killer stimulatory factor
|
|
US5242824A
(en)
|
1988-12-22 |
1993-09-07 |
Oncogen |
Monoclonal antibody to human carcinomas
|
|
US5530101A
(en)
*
|
1988-12-28 |
1996-06-25 |
Protein Design Labs, Inc. |
Humanized immunoglobulins
|
|
US5225538A
(en)
*
|
1989-02-23 |
1993-07-06 |
Genentech, Inc. |
Lymphocyte homing receptor/immunoglobulin fusion proteins
|
|
US5116964A
(en)
*
|
1989-02-23 |
1992-05-26 |
Genentech, Inc. |
Hybrid immunoglobulins
|
|
US5703055A
(en)
*
|
1989-03-21 |
1997-12-30 |
Wisconsin Alumni Research Foundation |
Generation of antibodies through lipid mediated DNA delivery
|
|
US5166322A
(en)
|
1989-04-21 |
1992-11-24 |
Genetics Institute |
Cysteine added variants of interleukin-3 and chemical modifications thereof
|
|
IE63847B1
(en)
|
1989-05-05 |
1995-06-14 |
Res Dev Foundation |
A novel antibody delivery system for biological response modifiers
|
|
US6291158B1
(en)
*
|
1989-05-16 |
2001-09-18 |
Scripps Research Institute |
Method for tapping the immunological repertoire
|
|
US5399346A
(en)
*
|
1989-06-14 |
1995-03-21 |
The United States Of America As Represented By The Department Of Health And Human Services |
Gene therapy
|
|
ATE123065T1
(de)
*
|
1989-07-07 |
1995-06-15 |
Takeda Chemical Industries Ltd |
Proteine und deren herstellung.
|
|
US5073627A
(en)
|
1989-08-22 |
1991-12-17 |
Immunex Corporation |
Fusion proteins comprising GM-CSF and IL-3
|
|
KR100263845B1
(ko)
|
1989-10-13 |
2000-08-16 |
스튜어트 엘.왓트 |
에리트로포이에틴 동형체와 그의 제조방법 및 그를 포함하는제약학적 조성물
|
|
US5856298A
(en)
|
1989-10-13 |
1999-01-05 |
Amgen Inc. |
Erythropoietin isoforms
|
|
DE69034249T2
(de)
|
1989-12-22 |
2008-05-29 |
F. Hoffmann-La Roche Ag |
Monoklonale Antikörper spezifisch für den zytotoxischen Lymphozyten-Reifefaktor
|
|
US5314995A
(en)
|
1990-01-22 |
1994-05-24 |
Oncogen |
Therapeutic interleukin-2-antibody based fusion proteins
|
|
US5349053A
(en)
*
|
1990-06-01 |
1994-09-20 |
Protein Design Labs, Inc. |
Chimeric ligand/immunoglobulin molecules and their uses
|
|
US7253264B1
(en)
|
1990-06-28 |
2007-08-07 |
Sanofi-Arentideutschland GmbH |
Immunoglobulin fusion proteins, their production and use
|
|
US5650150A
(en)
*
|
1990-11-09 |
1997-07-22 |
Gillies; Stephen D. |
Recombinant antibody cytokine fusion proteins
|
|
US5709859A
(en)
*
|
1991-01-24 |
1998-01-20 |
Bristol-Myers Squibb Company |
Mixed specificity fusion proteins
|
|
US6072039A
(en)
|
1991-04-19 |
2000-06-06 |
Rohm And Haas Company |
Hybrid polypeptide comparing a biotinylated avidin binding polypeptide fused to a polypeptide of interest
|
|
DE69233482T2
(de)
|
1991-05-17 |
2006-01-12 |
Merck & Co., Inc. |
Verfahren zur Verminderung der Immunogenität der variablen Antikörperdomänen
|
|
US5199942A
(en)
*
|
1991-06-07 |
1993-04-06 |
Immunex Corporation |
Method for improving autologous transplantation
|
|
CA2116533A1
(en)
|
1991-08-30 |
1993-03-18 |
George J. Todaro |
Hybrid cytokines
|
|
US20020037558A1
(en)
*
|
1991-10-23 |
2002-03-28 |
Kin-Ming Lo |
E.coli produced immunoglobulin constructs
|
|
US6627615B1
(en)
*
|
1991-12-17 |
2003-09-30 |
The Regents Of The University Of California |
Methods and compositions for in vivo gene therapy
|
|
ES2215991T3
(es)
*
|
1992-04-01 |
2004-10-16 |
The Rockefeller University |
Procedimiento para la proliferacion (in vitro) de precursores de celulas dendriticas y su uso para producir inmunogenos.
|
|
DK0615451T3
(da)
*
|
1992-05-26 |
2006-04-24 |
Immunex Corp |
Hidtil ukendt cytokin der binder til CD30
|
|
EP0646178A1
(de)
*
|
1992-06-04 |
1995-04-05 |
The Regents Of The University Of California |
Expression kassette mit im säugetier wirt funktionnellen regulator sequenzen
|
|
US5614184A
(en)
*
|
1992-07-28 |
1997-03-25 |
New England Deaconess Hospital |
Recombinant human erythropoietin mutants and therapeutic methods employing them
|
|
CA2142007C
(en)
*
|
1992-08-11 |
2007-10-30 |
Robert Glen Urban |
Immunomodulatory peptides
|
|
DE4228839A1
(de)
|
1992-08-29 |
1994-03-03 |
Behringwerke Ag |
Verfahren zum Nachweis und zur Bestimmung von Mediatoren
|
|
US5639641A
(en)
*
|
1992-09-09 |
1997-06-17 |
Immunogen Inc. |
Resurfacing of rodent antibodies
|
|
CA2126967A1
(en)
*
|
1992-11-04 |
1994-05-11 |
Anna M. Wu |
Novel antibody construct
|
|
DK0668777T3
(da)
*
|
1992-11-05 |
2007-02-19 |
Sloan Kettering Inst Cancer |
Prostataspecifikt membran-antigen
|
|
US5738849A
(en)
*
|
1992-11-24 |
1998-04-14 |
G. D. Searle & Co. |
Interleukin-3 (IL-3) variant fusion proteins, their recombinant production, and therapeutic compositions comprising them
|
|
US5543297A
(en)
*
|
1992-12-22 |
1996-08-06 |
Merck Frosst Canada, Inc. |
Human cyclooxygenase-2 cDNA and assays for evaluating cyclooxygenase-2 activity
|
|
US6096331A
(en)
|
1993-02-22 |
2000-08-01 |
Vivorx Pharmaceuticals, Inc. |
Methods and compositions useful for administration of chemotherapeutic agents
|
|
US5738852A
(en)
*
|
1993-04-20 |
1998-04-14 |
Solis Therapeutics, Inc. |
Methods of enhancing antigen-specific T cell responses
|
|
US5759551A
(en)
*
|
1993-04-27 |
1998-06-02 |
United Biomedical, Inc. |
Immunogenic LHRH peptide constructs and synthetic universal immune stimulators for vaccines
|
|
HUT73876A
(en)
*
|
1993-04-29 |
1996-10-28 |
Abbott Lab |
Erythropoietin analog compositions and methods
|
|
US5554512A
(en)
*
|
1993-05-24 |
1996-09-10 |
Immunex Corporation |
Ligands for flt3 receptors
|
|
CA2125763C
(en)
*
|
1993-07-02 |
2007-08-28 |
Maurice Kent Gately |
P40 homodimer of interleukin-12
|
|
IL192290A0
(en)
|
1993-08-17 |
2008-12-29 |
Kirin Amgen Inc |
Erythropoietin analogs
|
|
US5639725A
(en)
*
|
1994-04-26 |
1997-06-17 |
Children's Hospital Medical Center Corp. |
Angiostatin protein
|
|
US5837682A
(en)
*
|
1996-03-08 |
1998-11-17 |
The Children's Medical Center Corporation |
Angiostatin fragments and method of use
|
|
NZ285501A
(en)
*
|
1994-04-26 |
1998-02-26 |
Childrens Medical Center |
Plasminogen analogs (angiostatin), endothelial inhibitors, assays and kits
|
|
CU22615A1
(es)
*
|
1994-06-30 |
2000-02-10 |
Centro Inmunologia Molecular |
Procedimiento de obtención de anticuerpos monoclonales murinos menos inmunogénicos. anticuerpos monoclonales obtenidos
|
|
US6429199B1
(en)
*
|
1994-07-15 |
2002-08-06 |
University Of Iowa Research Foundation |
Immunostimulatory nucleic acid molecules for activating dendritic cells
|
|
US6309853B1
(en)
|
1994-08-17 |
2001-10-30 |
The Rockfeller University |
Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeutic uses thereof
|
|
US5888773A
(en)
*
|
1994-08-17 |
1999-03-30 |
The United States Of America As Represented By The Department Of Health And Human Services |
Method of producing single-chain Fv molecules
|
|
US5541087A
(en)
*
|
1994-09-14 |
1996-07-30 |
Fuji Immunopharmaceuticals Corporation |
Expression and export technology of proteins as immunofusins
|
|
DK0706799T3
(da)
|
1994-09-16 |
2002-02-25 |
Merck Patent Gmbh |
Immunkonjugater II
|
|
US6485726B1
(en)
|
1995-01-17 |
2002-11-26 |
The Brigham And Women's Hospital, Inc. |
Receptor specific transepithelial transport of therapeutics
|
|
US6086875A
(en)
*
|
1995-01-17 |
2000-07-11 |
The Brigham And Women's Hospital, Inc. |
Receptor specific transepithelial transport of immunogens
|
|
US5552524A
(en)
*
|
1995-01-31 |
1996-09-03 |
Eli Lilly And Company |
Anti-obesity proteins
|
|
US5691309A
(en)
*
|
1995-01-31 |
1997-11-25 |
Eli Lilly And Company |
Anti-obesity proteins
|
|
US5891680A
(en)
*
|
1995-02-08 |
1999-04-06 |
Whitehead Institute For Biomedical Research |
Bioactive fusion proteins comprising the p35 and p40 subunits of IL-12
|
|
JP3342873B2
(ja)
*
|
1995-03-10 |
2002-11-11 |
ジェネンテク・インコーポレイテッド |
ｇａｓ６による受容体活性化
|
|
US5719266A
(en)
*
|
1995-03-17 |
1998-02-17 |
Eli Lilly And Company |
Anti-obesity proteins
|
|
US6281010B1
(en)
*
|
1995-06-05 |
2001-08-28 |
The Trustees Of The University Of Pennsylvania |
Adenovirus gene therapy vehicle and cell line
|
|
IL122718A0
(en)
*
|
1995-06-30 |
1998-08-16 |
Lilly Co Eli |
Methods for treating diabetes
|
|
US6406689B1
(en)
*
|
1995-10-03 |
2002-06-18 |
Frank W. Falkenberg |
Compositions and methods for treatment of tumors and metastatic diseases
|
|
US5854205A
(en)
*
|
1995-10-23 |
1998-12-29 |
The Children's Medical Center Corporation |
Therapeutic antiangiogenic compositions and methods
|
|
US5723125A
(en)
*
|
1995-12-28 |
1998-03-03 |
Tanox Biosystems, Inc. |
Hybrid with interferon-alpha and an immunoglobulin Fc linked through a non-immunogenic peptide
|
|
US6080409A
(en)
*
|
1995-12-28 |
2000-06-27 |
Dendreon Corporation |
Immunostimulatory method
|
|
US6750334B1
(en)
*
|
1996-02-02 |
2004-06-15 |
Repligen Corporation |
CTLA4-immunoglobulin fusion proteins having modified effector functions and uses therefor
|
|
CA2205757C
(en)
*
|
1996-05-30 |
2006-01-24 |
F. Hoffmann-La Roche Ag |
Pyridazinone derivatives and their use as inhibitors of prostaglandin g/h synthase i and ii(cox i and ii)
|
|
US5922685A
(en)
*
|
1996-06-05 |
1999-07-13 |
Powderject Vaccines, Inc. |
IL-12 gene therapy of tumors
|
|
ATE218143T1
(de)
*
|
1996-09-03 |
2002-06-15 |
Gsf Forschungszentrum Umwelt |
Verwendung bi-und trispezifischer antikörper zur induktion einer tumorimmunität
|
|
US5994104A
(en)
*
|
1996-11-08 |
1999-11-30 |
Royal Free Hospital School Of Medicine |
Interleukin-12 fusion protein
|
|
US6100387A
(en)
*
|
1997-02-28 |
2000-08-08 |
Genetics Institute, Inc. |
Chimeric polypeptides containing chemokine domains
|
|
US6277375B1
(en)
*
|
1997-03-03 |
2001-08-21 |
Board Of Regents, The University Of Texas System |
Immunoglobulin-like domains with increased half-lives
|
|
EP0973550B1
(de)
*
|
1997-04-11 |
2002-10-09 |
G.D. SEARLE & CO. |
Antagonistische anti-avb3 integrin antikörper
|
|
PT970126E
(pt)
*
|
1997-04-14 |
2001-10-30 |
Micromet Ag |
Novo metodo para a producao de receptores de antigenios anti-humanos e suas utilizacoes
|
|
US5873423A
(en)
*
|
1997-07-31 |
1999-02-23 |
Briese Industrial Technologies, Inc. |
Frustum cutting bit arrangement
|
|
EP1037927B1
(de)
|
1997-12-08 |
2004-05-19 |
Lexigen Pharmaceuticals Corp. |
Heterodimäre fusionsproteine zur verwendung für gezielte immuntherapie und allgemeine immunerregung
|
|
US20030105294A1
(en)
|
1998-02-25 |
2003-06-05 |
Stephen Gillies |
Enhancing the circulating half life of antibody-based fusion proteins
|
|
CZ20003767A3
(cs)
*
|
1998-04-15 |
2002-01-16 |
Lexigen Pharmaceuticals Corp. |
Kompozice pro indukci imunitní odpovědi vůči zvolenému typu buňek v organismu savce a její pouľití pro výrobu léčiva
|
|
CZ20003817A3
(cs)
|
1998-04-17 |
2002-08-14 |
Lexigen Pharmaceuticals Corporation |
Léčivo pro indukci cytocidní imunitní odpovědi
|
|
US6284536B1
(en)
|
1998-04-20 |
2001-09-04 |
The Regents Of The University Of California |
Modified immunoglobin molecules and methods for use thereof
|
|
WO1999058662A1
(fr)
|
1998-05-14 |
1999-11-18 |
Merck Patent Gmbh |
Proteine fusionnee
|
|
US6620382B1
(en)
|
1998-05-22 |
2003-09-16 |
Biopheresis Technologies, Llc. |
Method and compositions for treatment of cancers
|
|
US20020142374A1
(en)
|
1998-08-17 |
2002-10-03 |
Michael Gallo |
Generation of modified molecules with increased serum half-lives
|
|
DE69942207D1
(de)
*
|
1998-08-25 |
2010-05-12 |
Merck Patent Gmbh |
Expression und export von angiostatin und endostatin als immunofusins
|
|
US6646113B1
(en)
*
|
1998-09-17 |
2003-11-11 |
The Trustees Of The University Of Pennsylvania |
Nucleic acid molecule encoding human survival of motor neuron-interacting protein 1 (SIP1) deletion mutants
|
|
US6335176B1
(en)
|
1998-10-16 |
2002-01-01 |
Pharmacopeia, Inc. |
Incorporation of phosphorylation sites
|
|
ID30327A
(id)
*
|
1999-01-07 |
2001-11-22 |
Lexigen Pharm Corp |
EKSPRESI DAN EKSPOR PROTEIN-PROTEIN ANTI OBESITAS SEBAGAI PROTEIN-PROTEIN FUSI Fc
|
|
CN100352921C
(zh)
|
1999-05-06 |
2007-12-05 |
威克福雷大学 |
用于鉴定引起免疫反应的抗原的组合物和方法
|
|
US6348192B1
(en)
*
|
1999-05-11 |
2002-02-19 |
Bayer Corporation |
Interleukin-2 mutein expressed from mammalian cells
|
|
WO2000069913A1
(en)
|
1999-05-19 |
2000-11-23 |
Lexigen Pharmaceuticals Corp. |
EXPRESSION AND EXPORT OF INTERFERON-ALPHA PROTEINS AS Fc FUSION PROTEINS
|
|
CZ299516B6
(cs)
|
1999-07-02 |
2008-08-20 |
F. Hoffmann-La Roche Ag |
Konjugát erythropoetinového glykoproteinu, zpusobjeho výroby a použití a farmaceutická kompozice sjeho obsahem
|
|
JO2291B1
(en)
|
1999-07-02 |
2005-09-12 |
اف . هوفمان لاروش ايه جي |
Erythropoietin derivatives
|
|
SK782002A3
(en)
|
1999-07-21 |
2003-08-05 |
Lexigen Pharm Corp |
FC fusion proteins for enhancing the immunogenicity of protein and peptide antigens
|
|
US7067110B1
(en)
|
1999-07-21 |
2006-06-27 |
Emd Lexigen Research Center Corp. |
Fc fusion proteins for enhancing the immunogenicity of protein and peptide antigens
|
|
ATE316982T1
(de)
|
1999-08-09 |
2006-02-15 |
Lexigen Pharm Corp |
Mehrere zytokin-antikörper komplexen
|
|
US20050202538A1
(en)
|
1999-11-12 |
2005-09-15 |
Merck Patent Gmbh |
Fc-erythropoietin fusion protein with improved pharmacokinetics
|
|
CA2391080A1
(en)
|
1999-11-12 |
2001-05-25 |
Merck Patent Gesellschaft Mit Beschraenkter Haftung |
Erythropoietin forms with improved properties
|
|
DE60122286T2
(de)
|
2000-02-11 |
2007-08-02 |
Merck Patent Gmbh |
Steigerung der zirkulierenden halbwertzeit von auf antikörpern basierenden fusionsproteinen
|
|
ES2269361T3
(es)
|
2000-02-24 |
2007-04-01 |
Philogen S.P.A. |
Composiciones y metodos para tratamiento de la angiogenesis en lesiones patologicas.
|
|
US6586398B1
(en)
|
2000-04-07 |
2003-07-01 |
Amgen, Inc. |
Chemically modified novel erythropoietin stimulating protein compositions and methods
|
|
EP1285072A2
(de)
|
2000-05-12 |
2003-02-26 |
Neose Technologies, Inc. |
In vitro fucosylierung von rekombinanten glycoproteinen
|
|
EP1294401B1
(de)
|
2000-06-29 |
2007-08-01 |
EMD Lexigen Research Center Corp. |
Steigerung von durch antikörper-zytokin-fusionsproteine mediierten immunantworten durch eine kombinierte behandlung mit mitteln zur erhöhung der immunzytokinaufnahme
|
|
WO2002057435A2
(en)
*
|
2001-01-18 |
2002-07-25 |
Merck Patent Gmbh |
Bifunctional fusion proteins with glucocerebrosidase activity
|
|
PL362324A1
(en)
*
|
2001-02-19 |
2004-10-18 |
Merck Patent Gmbh |
Artificial fusion proteins with reduced immunogenicity
|
|
ATE400030T1
(de)
*
|
2001-02-19 |
2008-07-15 |
Merck Patent Gmbh |
Methode zur identifizierung von t-zellepitopen und deren anwendung zur herstellung von molekülen mit reduzierter immunogenität
|
|
KR20090010127A
(ko)
|
2001-03-07 |
2009-01-28 |
메르크 파텐트 게엠베하 |
하이브리드 이소타입 항체 부분구조를 포함하는 단백질을 위한 발현 기술
|
|
WO2002079415A2
(en)
|
2001-03-30 |
2002-10-10 |
Lexigen Pharmaceuticals Corp. |
Reducing the immunogenicity of fusion proteins
|
|
BR0209177A
(pt)
|
2001-05-03 |
2004-10-05 |
Merck Patent Gmbh |
Anticorpo especìfico a tumor recombinante e uso do mesmo
|
|
TW544602B
(en)
*
|
2001-08-08 |
2003-08-01 |
Hon Hai Prec Ind Co Ltd |
Delivery notification system
|
|
EP2354791A1
(de)
|
2001-12-04 |
2011-08-10 |
Merck Patent GmbH |
Immunocytokine mit modulierter Selektivität
|
|
BRPI0317376B8
(pt)
|
2002-12-17 |
2021-05-25 |
Merck Patent Gmbh |
proteína de fusão de anticorpo-il2 designada como hu14.18-il2, usos da mesma, vetor e composição farmacêutica
|
|
US20050069521A1
(en)
|
2003-08-28 |
2005-03-31 |
Emd Lexigen Research Center Corp. |
Enhancing the circulating half-life of interleukin-2 proteins
|
|
CN100467488C
(zh)
|
2003-12-30 |
2009-03-11 |
默克专利有限公司 |
Il-7融合蛋白
|
|
WO2005063808A1
(en)
|
2003-12-31 |
2005-07-14 |
Merck Patent Gmbh |
Fc-ERYTHROPOIETIN FUSION PROTEIN WITH IMPROVED PHARMACOKINETICS
|
|
WO2005070967A2
(en)
|
2004-01-22 |
2005-08-04 |
Merck Patent Gmbh |
Anti-cancer antibodies with reduced complement fixation
|
|
US7670595B2
(en)
|
2004-06-28 |
2010-03-02 |
Merck Patent Gmbh |
Fc-interferon-beta fusion proteins
|
|
CN101072793B
(zh)
|
2004-12-09 |
2012-06-20 |
默克专利有限公司 |
具有降低的免疫原性的il-7变体
|
|
US20070104689A1
(en)
|
2005-09-27 |
2007-05-10 |
Merck Patent Gmbh |
Compositions and methods for treating tumors presenting survivin antigens
|
|
ATE555125T1
(de)
|
2005-12-30 |
2012-05-15 |
Merck Patent Gmbh |
Interleukin-12p40-varianten mit verbesserter stabilität
|
|
PL1966244T3
(pl)
|
2005-12-30 |
2012-08-31 |
Merck Patent Gmbh |
Przeciwciała anty-il-6 zapobiegające wiązaniu il-6 skompleksowanego z il-6ralpha do gp130
|
|
EA016429B1
(ru)
|
2005-12-30 |
2012-04-30 |
Мерк Патент Гмбх |
Антитела против cd19 с пониженной иммуногенностью
|
|
JP5474531B2
(ja)
|
2006-03-24 |
2014-04-16 |
メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング |
操作されたヘテロ二量体タンパク質ドメイン
|
|
CA2656700A1
(en)
|
2006-07-06 |
2008-01-10 |
Merck Patent Gesellschaft Mit Beschraenkter Haftung |
Compositions and methods for enhancing the efficacy of il-2 mediated immune responses
|