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BR112013008355A2 - formas cristalinas do sal de sódio de ácido (4-{4-[5-(6-trifluorometil-piridin-3-ilamino)-piridin-2-il]-fenil}-ciclo-hexil)-acético - Google Patents

formas cristalinas do sal de sódio de ácido (4-{4-[5-(6-trifluorometil-piridin-3-ilamino)-piridin-2-il]-fenil}-ciclo-hexil)-acético

Info

Publication number
BR112013008355A2
BR112013008355A2 BR112013008355A BR112013008355A BR112013008355A2 BR 112013008355 A2 BR112013008355 A2 BR 112013008355A2 BR 112013008355 A BR112013008355 A BR 112013008355A BR 112013008355 A BR112013008355 A BR 112013008355A BR 112013008355 A2 BR112013008355 A2 BR 112013008355A2
Authority
BR
Brazil
Prior art keywords
pyridin
crystalline forms
ylamino
trifluoromethyl
cyclohexyl
Prior art date
Application number
BR112013008355A
Other languages
English (en)
Inventor
Edwin Bernard Villhauer
Jessica Liang
Mahavir Prashad
Michael J Girgis
Paul Allen Sutton
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44802409&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR112013008355(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of BR112013008355A2 publication Critical patent/BR112013008355A2/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

formas cristalinas do sal de sódio de ácido (4-{4-[5-(6-trifluorometil-piridin-3-ilamino)-piridin-2-il]-fenil}-ciclo-hexil)-acético. a presente invenção refere-se a novas formas cristalinas de ácido (4-{4-[5-(6-trifluorometil-piridin-3-ilamino)-piridin-2-il]-fenil}-ciclo-hexil)-acético, sódio, e seu uso no tratamento ou prevenção de uma condição ou um distúrbio associado com a atividade de dgat1 em animais, particularmente, seres humanos. ela também se refere aos processos para fazer tais novas formas cristalinas.
BR112013008355A 2010-10-07 2011-10-05 formas cristalinas do sal de sódio de ácido (4-{4-[5-(6-trifluorometil-piridin-3-ilamino)-piridin-2-il]-fenil}-ciclo-hexil)-acético BR112013008355A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US39088810P 2010-10-07 2010-10-07
PCT/US2011/054841 WO2012047948A1 (en) 2010-10-07 2011-10-05 New crystalline forms of the sodium salt of (4- {4- [5- ( 6 - trifluoromethyl - pyridin- 3 - ylamino ) - pyridin- 2 -yl] -phenyl} - cyclohexyl) -acetic acid

Publications (1)

Publication Number Publication Date
BR112013008355A2 true BR112013008355A2 (pt) 2016-06-14

Family

ID=44802409

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112013008355A BR112013008355A2 (pt) 2010-10-07 2011-10-05 formas cristalinas do sal de sódio de ácido (4-{4-[5-(6-trifluorometil-piridin-3-ilamino)-piridin-2-il]-fenil}-ciclo-hexil)-acético

Country Status (25)

Country Link
US (2) US8829194B2 (pt)
EP (2) EP2625172B1 (pt)
JP (1) JP6093703B2 (pt)
KR (2) KR20130115277A (pt)
CN (1) CN103153981B (pt)
AR (1) AR083317A1 (pt)
AU (1) AU2011312185B2 (pt)
BR (1) BR112013008355A2 (pt)
CA (1) CA2813736C (pt)
CL (1) CL2013000929A1 (pt)
CO (1) CO6710909A2 (pt)
EC (1) ECSP13012608A (pt)
ES (2) ES2618411T3 (pt)
GT (1) GT201300089A (pt)
IL (1) IL225532A0 (pt)
MA (1) MA34645B1 (pt)
MX (1) MX2013003835A (pt)
NZ (1) NZ608557A (pt)
PE (1) PE20140337A1 (pt)
PL (2) PL2781516T3 (pt)
PT (2) PT2625172T (pt)
RU (1) RU2612556C2 (pt)
SG (1) SG188586A1 (pt)
TW (1) TW201217360A (pt)
WO (1) WO2012047948A1 (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112013008355A2 (pt) * 2010-10-07 2016-06-14 Novartis Ag formas cristalinas do sal de sódio de ácido (4-{4-[5-(6-trifluorometil-piridin-3-ilamino)-piridin-2-il]-fenil}-ciclo-hexil)-acético
MX2014002141A (es) * 2011-09-12 2014-03-31 Hoffmann La Roche Carboxamidas de n-(5-cicloalquil - o 5-heterociclil-)-piridin-3-il o.
KR20150013194A (ko) 2012-04-27 2015-02-04 노파르티스 아게 시클릭 브리지헤드 에테르 dgat1 억제제
WO2013163508A1 (en) * 2012-04-27 2013-10-31 Novartis Ag Tetrahydropyran dgat1 inhibitors
WO2013169648A1 (en) * 2012-05-07 2013-11-14 Novartis Ag Pharmaceutical combinations comprising a dgat1 inhibtor and a triglyceride lowering drug
KR101646716B1 (ko) 2016-02-15 2016-08-08 서성환 조립식 나선계단용 스페이서 및 이를 이용한 조립식 나선계단
CN113194959A (zh) * 2018-12-20 2021-07-30 默沙东公司 Nrtti化合物的新型结晶形式

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200303742A (en) 2001-11-21 2003-09-16 Novartis Ag Organic compounds
US7652061B2 (en) 2003-05-20 2010-01-26 Novartis A.G. N-acyl nitrogen heterocycles as ligands of peroxisome proliferator-activated receptors
WO2005097085A1 (en) 2004-04-08 2005-10-20 Micro Nutrient, Llc Nutrient system for individualized responsive dosing regimens
CN101415683B (zh) * 2006-03-31 2013-07-17 诺瓦提斯公司 新化合物
US20100016387A1 (en) * 2006-12-11 2010-01-21 Avirup Bose Method of treatment
BR112013008355A2 (pt) * 2010-10-07 2016-06-14 Novartis Ag formas cristalinas do sal de sódio de ácido (4-{4-[5-(6-trifluorometil-piridin-3-ilamino)-piridin-2-il]-fenil}-ciclo-hexil)-acético

Also Published As

Publication number Publication date
TW201217360A (en) 2012-05-01
KR20180011337A (ko) 2018-01-31
EP2781516A2 (en) 2014-09-24
KR101900652B1 (ko) 2018-09-19
AU2011312185B2 (en) 2015-07-02
AU2011312185A1 (en) 2013-04-04
CA2813736A1 (en) 2012-04-12
RU2013120549A (ru) 2014-11-20
CA2813736C (en) 2020-03-24
US20140343102A1 (en) 2014-11-20
PT2781516T (pt) 2017-03-15
US20130184311A1 (en) 2013-07-18
ES2618411T3 (es) 2017-06-21
SG188586A1 (en) 2013-04-30
CO6710909A2 (es) 2013-07-15
CN103153981A (zh) 2013-06-12
PL2781516T3 (pl) 2017-05-31
JP6093703B2 (ja) 2017-03-08
EP2781516A3 (en) 2014-10-15
WO2012047948A1 (en) 2012-04-12
EP2625172B1 (en) 2016-12-07
RU2612556C2 (ru) 2017-03-09
PT2625172T (pt) 2017-03-10
NZ608557A (en) 2015-02-27
MX2013003835A (es) 2013-06-28
IL225532A0 (en) 2013-06-27
KR20130115277A (ko) 2013-10-21
US8829194B2 (en) 2014-09-09
JP2013539755A (ja) 2013-10-28
CN103153981B (zh) 2017-10-10
ECSP13012608A (es) 2013-07-31
PL2625172T3 (pl) 2017-07-31
PE20140337A1 (es) 2014-03-13
AR083317A1 (es) 2013-02-13
ES2618426T3 (es) 2017-06-21
GT201300089A (es) 2014-12-30
EP2625172A1 (en) 2013-08-14
EP2781516B1 (en) 2016-12-07
CL2013000929A1 (es) 2013-09-27
MA34645B1 (fr) 2013-11-02

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