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BR112013005141A2 - diazetidinil diamida como inibidores de monoacilglicerol lipase - Google Patents

diazetidinil diamida como inibidores de monoacilglicerol lipase

Info

Publication number
BR112013005141A2
BR112013005141A2 BR112013005141A BR112013005141A BR112013005141A2 BR 112013005141 A2 BR112013005141 A2 BR 112013005141A2 BR 112013005141 A BR112013005141 A BR 112013005141A BR 112013005141 A BR112013005141 A BR 112013005141A BR 112013005141 A2 BR112013005141 A2 BR 112013005141A2
Authority
BR
Brazil
Prior art keywords
diamide
lipase inhibitors
diazetidinyl
monoacylglycerol lipase
compounds
Prior art date
Application number
BR112013005141A
Other languages
English (en)
Inventor
Bin Zhu
Mark J Macielag
Peter J Connolly
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of BR112013005141A2 publication Critical patent/BR112013005141A2/pt

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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/4035—Isoindoles, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/423—Oxazoles condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
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  • Endocrinology (AREA)
  • Reproductive Health (AREA)
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  • Plural Heterocyclic Compounds (AREA)
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Abstract

di-azetidinil diamidea como inibidores de monoacilglicerol lipase. a presente invenção refere-se a compostos, composições e métodos para o tratamento de várias doenças , síndromes, condições e distúrbios incluindo dor. tais compostos são representados pela fórmula (i) a seguir: fórmula (i) em que q e z são aqui definidos.
BR112013005141A 2010-09-03 2011-08-31 diazetidinil diamida como inibidores de monoacilglicerol lipase BR112013005141A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37976410P 2010-09-03 2010-09-03
PCT/US2011/049885 WO2012030907A1 (en) 2010-09-03 2011-08-31 Di-azetidinyl diamide as monoacylglycerol lipase inhibitors

Publications (1)

Publication Number Publication Date
BR112013005141A2 true BR112013005141A2 (pt) 2016-05-10

Family

ID=44645814

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112013005141A BR112013005141A2 (pt) 2010-09-03 2011-08-31 diazetidinil diamida como inibidores de monoacilglicerol lipase

Country Status (12)

Country Link
US (3) US20120058986A1 (pt)
EP (1) EP2611774B1 (pt)
JP (1) JP2013536852A (pt)
KR (1) KR20130101040A (pt)
CN (1) CN103068798A (pt)
AR (1) AR082891A1 (pt)
AU (1) AU2011296068B2 (pt)
BR (1) BR112013005141A2 (pt)
CA (1) CA2809991A1 (pt)
RU (1) RU2013114771A (pt)
TW (1) TW201305132A (pt)
WO (1) WO2012030907A1 (pt)

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