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BR112017024534A2 - sistemas de rna-guia/endonuclease cas9 inovadores - Google Patents

sistemas de rna-guia/endonuclease cas9 inovadores

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Publication number
BR112017024534A2
BR112017024534A2 BR112017024534A BR112017024534A BR112017024534A2 BR 112017024534 A2 BR112017024534 A2 BR 112017024534A2 BR 112017024534 A BR112017024534 A BR 112017024534A BR 112017024534 A BR112017024534 A BR 112017024534A BR 112017024534 A2 BR112017024534 A2 BR 112017024534A2
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BR
Brazil
Prior art keywords
innovative
endonuclease systems
genome
dsm
lactobacillus
Prior art date
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BR112017024534A
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English (en)
Inventor
Mark Cigan Andrew
Gasiunas Giedrius
K Young Joshua
Karvelis Tautvydas
Siksnys Virginijus
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Pioneer Hi Bred Int
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Publication date
Application filed by Pioneer Hi Bred Int filed Critical Pioneer Hi Bred Int
Publication of BR112017024534A2 publication Critical patent/BR112017024534A2/pt

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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPRs]
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    • C12N2800/00—Nucleic acids vectors
    • C12N2800/80—Vectors containing sites for inducing double-stranded breaks, e.g. meganuclease restriction sites

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Abstract

trata-se de composições e métodos fornecidos para sistemas de rna-guia/endonuclease cas9 inovadores. os sistemas de endonuclease cas9 tipo ii que se originam de brevibacillus laterosporus, lactobacillus reuteri mlc3, lactobacillus rossiae dsm 15814, pediococcus pentosaceus sl4, lactobacillus nodensis jcm 14932, sulfurospirillum sp. scadc, bifidobacterium thermophilum dsm 20210, loktanella vestfoldensis, sphingomonas sanxanigenens nx02, epilithonimonas tenax dsm 16811, sporocytophaga myxococcoides são descritos no presente documento. a presente revelação também descreve métodos para modificação de genoma de uma sequência-alvo no genoma de uma célula, para edição de gene e para inserção de um polinucleotídeo de interesse no genoma de uma célula.
BR112017024534A 2015-05-15 2016-05-12 sistemas de rna-guia/endonuclease cas9 inovadores BR112017024534A2 (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201562162377P 2015-05-15 2015-05-15
US201562162353P 2015-05-15 2015-05-15
US201562196535P 2015-07-24 2015-07-24
PCT/US2016/032073 WO2016186953A1 (en) 2015-05-15 2016-05-12 Guide rna/cas endonuclease systems

Publications (1)

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BR112017024534A2 true BR112017024534A2 (pt) 2018-07-24

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BR112017024534A BR112017024534A2 (pt) 2015-05-15 2016-05-12 sistemas de rna-guia/endonuclease cas9 inovadores

Country Status (9)

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US (4) US11371050B2 (pt)
EP (2) EP3294878A1 (pt)
KR (2) KR20180002852A (pt)
CN (2) CN107709562A (pt)
AU (3) AU2016263026A1 (pt)
BR (1) BR112017024534A2 (pt)
CA (2) CA2985079A1 (pt)
MX (2) MX2017014560A (pt)
WO (2) WO2016186953A1 (pt)

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