BR112017009701A2 - composto e métodos para a preparação de um composto - Google Patents
composto e métodos para a preparação de um compostoInfo
- Publication number
- BR112017009701A2 BR112017009701A2 BR112017009701-0A BR112017009701A BR112017009701A2 BR 112017009701 A2 BR112017009701 A2 BR 112017009701A2 BR 112017009701 A BR112017009701 A BR 112017009701A BR 112017009701 A2 BR112017009701 A2 BR 112017009701A2
- Authority
- BR
- Brazil
- Prior art keywords
- compound
- formula
- preparation
- present
- methods
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/02—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B31/00—Reduction in general
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
- C07C233/04—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C233/07—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/12—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups
- C07C233/15—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
- C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
- C07D207/277—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
a presente invenção se refere aos compostos de fórmula i, incluindo todos os estereoisômeros e seus sais, em que q1, q2 e r são conforme definidos na presente invenção. a presente invenção também se refere a um método para a preparação de um composto de fórmula i, que compreende o contato de um composto de fórmula ii com um composto de fórmula iii, opcionalmente na presença de um catalisador ou de uma base para a formação de um composto de fórmula i. a presente invenção ainda se refere a um método para a preparação de um composto de fórmula iv, que compreende a ciclização redutiva de um composto de fórmula i na presença de um agente de redução.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462088971P | 2014-12-08 | 2014-12-08 | |
| US62/088,971 | 2014-12-08 | ||
| PCT/US2015/063101 WO2016094117A1 (en) | 2014-12-08 | 2015-12-01 | 3-oxo-3-(arylamino)propanoates, a process for their preparation, and their use in preparing pyrrolidinones |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BR112017009701A2 true BR112017009701A2 (pt) | 2018-02-20 |
| BR112017009701B1 BR112017009701B1 (pt) | 2021-09-08 |
Family
ID=54782892
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112017009701-0A BR112017009701B1 (pt) | 2014-12-08 | 2015-12-01 | Composto e métodos de preparação de compostos |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US10227286B2 (pt) |
| EP (1) | EP3230264B1 (pt) |
| JP (1) | JP6611816B2 (pt) |
| KR (1) | KR102542215B1 (pt) |
| CN (1) | CN107001260B (pt) |
| AR (1) | AR102939A1 (pt) |
| AU (1) | AU2015361018B2 (pt) |
| BR (1) | BR112017009701B1 (pt) |
| ES (1) | ES2759267T3 (pt) |
| HU (1) | HUE047582T2 (pt) |
| IL (1) | IL252637A (pt) |
| MX (1) | MX2017007087A (pt) |
| PL (1) | PL3230264T3 (pt) |
| RU (1) | RU2712831C2 (pt) |
| SG (1) | SG11201702924WA (pt) |
| TW (1) | TWI694982B (pt) |
| WO (1) | WO2016094117A1 (pt) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUE059730T2 (hu) | 2013-12-03 | 2022-12-28 | Fmc Corp | Pirrolidinon herbicidek |
| US11589583B2 (en) * | 2013-12-03 | 2023-02-28 | Fmc Corporation | Pyrrolidinones herbicides |
| EP3164386B1 (en) | 2014-07-02 | 2020-10-07 | FMC Corporation | Piperidinone herbicides |
| EP3280709B1 (en) | 2015-04-10 | 2021-05-26 | FMC Corporation | Substituted cyclic amides as herbicides |
| CN107531658B (zh) | 2015-04-27 | 2021-07-27 | Fmc公司 | 作为除草剂的丁内酯 |
| CA2980643C (en) | 2015-05-12 | 2023-10-17 | E I Du Pont De Nemours And Company | Aryl substituted bicyclic compounds as herbicides |
| US10906873B2 (en) | 2015-05-29 | 2021-02-02 | Fmc Corporation | Substituted cyclic amides as herbicides |
| CA2983759A1 (en) | 2015-06-02 | 2016-12-08 | E I Du Pont De Nemours And Company | Substituted cyclic amides and their use as herbicides |
| EP3328836B1 (en) | 2015-07-31 | 2021-03-24 | FMC Corporation | Cyclic n-carboxamide compounds useful as herbicides |
| GB201617050D0 (en) | 2016-10-07 | 2016-11-23 | Syngenta Participations Ag | Herbicidal mixtures |
| AU2017378640B2 (en) | 2016-12-21 | 2022-03-03 | Fmc Corporation | Nitrone herbicides |
| CN110691516B (zh) | 2017-03-21 | 2022-10-28 | Fmc公司 | 吡咯烷酮及其制备方法 |
| BR112019019551A2 (pt) | 2017-03-21 | 2020-04-22 | Fmc Corp | mistura, e, método para controlar o crescimento de vegetação indesejada |
| WO2018177837A1 (de) | 2017-03-30 | 2018-10-04 | Bayer Aktiengesellschaft | 4-cyclopentyl- und 4-cyclopropyl-2-oxopyrrolidin-3-carboxami d-derivate und verwandte verbindungen als herbizide pflanzenschutzmittel |
| WO2018177836A1 (de) | 2017-03-30 | 2018-10-04 | Bayer Aktiengesellschaft | N-cyclopropyl-2-oxopyrrolidin-3-carboxamid-derivate und verwandte verbindungen als herbizide pflanzenschutzmittel |
| AR111967A1 (es) | 2017-05-30 | 2019-09-04 | Fmc Corp | Amidas herbicidas |
| AR111839A1 (es) | 2017-05-30 | 2019-08-21 | Fmc Corp | Lactamas 3-sustituidas herbicidas |
| WO2019025156A1 (de) | 2017-08-03 | 2019-02-07 | Bayer Aktiengesellschaft | Substituierte pyrrolidinone sowie deren salze und ihre verwendung als herbizide wirkstoffe |
| GB201819747D0 (en) | 2018-12-04 | 2019-01-16 | Syngenta Participations Ag | Herbicidal compositions |
| EP3923724B1 (en) | 2019-02-15 | 2023-07-26 | Syngenta Crop Protection AG | Herbicidal compositions |
Family Cites Families (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1262277B (de) | 1962-12-05 | 1968-03-07 | Basf Ag | Verfahren zur Herstellung von Pyrrolidonen |
| US3741989A (en) | 1970-10-27 | 1973-06-26 | Abbott Lab | Lactonic acetals |
| JPS5356288A (en) | 1976-10-30 | 1978-05-22 | Matsushita Electric Works Ltd | Preparation of phenolic resin |
| JPS5488114A (en) | 1977-12-26 | 1979-07-13 | Fuji Photo Film Co Ltd | Manufacturing device for photograph seal |
| US4594094A (en) | 1983-04-04 | 1986-06-10 | Shell Oil Company | Oxacycloalkane-alpha-(thio)carboxylic acid derivatives and use as plant growth regulators and herbicides |
| US4874422A (en) * | 1988-12-27 | 1989-10-17 | Ici Americas Inc. | 1-Phenyl-3-carboxyamidopyrrolidones and their use as herbicides |
| JP3487669B2 (ja) | 1995-03-28 | 2004-01-19 | 積水化学工業株式会社 | 不飽和ポリエステル樹脂組成物 |
| AU5195999A (en) | 1998-08-11 | 2000-03-06 | Takeda Chemical Industries Ltd. | Cyclic amide compounds, process for producing the same, intermediates thereof and herbicides |
| JP4351909B2 (ja) | 2001-10-08 | 2009-10-28 | ユセベ ファルマ ソシエテ アノニム | 薬剤を調製するための、２−オキソ−１−ピロリジン誘導体の使用 |
| AU2003268184A1 (en) | 2002-08-23 | 2004-03-11 | Chiron Corporation | Pyrrole based inhibitors of glycogen synthase kinase 3 |
| WO2004037787A1 (de) * | 2002-10-18 | 2004-05-06 | Basf Aktiengesellschaft | 1-phenylpyrrolidin-2-on-3-carboxamide |
| WO2004046081A1 (en) | 2002-11-15 | 2004-06-03 | Dna Link, Inc. | Beta-nitrostyrene compound and telomerase inhibitor having an anticancer activity |
| US7205318B2 (en) | 2003-03-18 | 2007-04-17 | Bristol-Myers Squibb Company | Lactam-containing cyclic diamines and derivatives as a factor Xa inhibitors |
| KR100890696B1 (ko) | 2005-01-28 | 2009-03-26 | 아이알엠 엘엘씨 | 아릴 피롤리돈의 합성 |
| US20070123508A1 (en) | 2005-05-27 | 2007-05-31 | Roger Olsson | PAR2-modulating compounds and their use |
| US8293926B2 (en) | 2005-12-09 | 2012-10-23 | Sumitomo Chemical Company, Limited | Method of producing optically active 4-amino-3-substituted phenylbutanoic acid |
| ES2304220B1 (es) | 2007-03-02 | 2009-09-11 | Universidad De Zaragoza | Composicion para el tratamiento de enfermedades infecciosas. |
| EP2065380A1 (en) | 2007-08-22 | 2009-06-03 | F.Hoffmann-La Roche Ag | Pyridoneamide derivatives as focal adhesion kinase (FAK) inhibitors and their use for the treatment of cancer |
| CN101412711A (zh) | 2007-10-15 | 2009-04-22 | 上海恒瑞医药有限公司 | 氨基甲酸酯类衍生物及其在医药上的应用 |
| JP5549592B2 (ja) | 2008-09-02 | 2014-07-16 | 日産化学工業株式会社 | オルト置換ハロアルキルスルホンアニリド誘導体及び除草剤 |
| EP2363390A4 (en) | 2008-11-04 | 2012-06-13 | Teijin Pharma Ltd | DERIVATIVE LACTAM OF VITAMIN D3 |
| WO2010094678A1 (en) * | 2009-02-23 | 2010-08-26 | F. Hoffmann-La Roche Ag | Novel ortho-aminoamides for the treatment of cancer |
| CN101747252A (zh) * | 2009-12-28 | 2010-06-23 | 嘉兴宜博生物医药科技有限公司 | R构诺普利兰的合成方法 |
| DK2603513T3 (da) | 2010-08-10 | 2020-06-15 | Takeda Pharmaceuticals Co | Heterocyklisk forbindelse og anvendelse deraf som AMPA-receptorpositiv allosterisk modulator |
| US8946216B2 (en) | 2010-09-01 | 2015-02-03 | Merck Sharp & Dohme Corp. | Indazole derivatives useful as ERK inhibitors |
| US9562055B2 (en) | 2011-05-13 | 2017-02-07 | Array Biopharma Inc. | Pyrrolidinyl urea, pyrrolidinyl thiourea and pyrrolidinyl guanidine compounds as TrkA kinase inhibitors |
| CN102531918B (zh) | 2012-01-18 | 2013-10-02 | 安阳工学院 | 一种对映纯对称反式二烷基环己胺的合成方法 |
| KR20130142477A (ko) | 2012-06-19 | 2013-12-30 | 순천향대학교 산학협력단 | 키랄 나이트로사이클로프로판 유도체의 제조방법 |
| WO2014065413A1 (ja) * | 2012-10-26 | 2014-05-01 | 日本たばこ産業株式会社 | トリアゾール・イソオキサゾール化合物およびその医薬用途 |
| HUE059730T2 (hu) | 2013-12-03 | 2022-12-28 | Fmc Corp | Pirrolidinon herbicidek |
| GB201321743D0 (en) | 2013-12-09 | 2014-01-22 | Ucb Pharma Sa | Therapeutic agents |
| RU2555370C1 (ru) | 2014-02-12 | 2015-07-10 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Самарский государственный технический университет" | Способ энантиоселективного синтеза диэтил[3-метил-(1s)-(нитрометил)бутил]малоната формулы i |
| EP3164386B1 (en) | 2014-07-02 | 2020-10-07 | FMC Corporation | Piperidinone herbicides |
| EP3280709B1 (en) | 2015-04-10 | 2021-05-26 | FMC Corporation | Substituted cyclic amides as herbicides |
| CN107531658B (zh) | 2015-04-27 | 2021-07-27 | Fmc公司 | 作为除草剂的丁内酯 |
| CA2980643C (en) | 2015-05-12 | 2023-10-17 | E I Du Pont De Nemours And Company | Aryl substituted bicyclic compounds as herbicides |
| US10906873B2 (en) | 2015-05-29 | 2021-02-02 | Fmc Corporation | Substituted cyclic amides as herbicides |
| CA2983759A1 (en) * | 2015-06-02 | 2016-12-08 | E I Du Pont De Nemours And Company | Substituted cyclic amides and their use as herbicides |
| EP3328836B1 (en) | 2015-07-31 | 2021-03-24 | FMC Corporation | Cyclic n-carboxamide compounds useful as herbicides |
| AU2017378640B2 (en) | 2016-12-21 | 2022-03-03 | Fmc Corporation | Nitrone herbicides |
| BR112019019551A2 (pt) | 2017-03-21 | 2020-04-22 | Fmc Corp | mistura, e, método para controlar o crescimento de vegetação indesejada |
| CN110691516B (zh) | 2017-03-21 | 2022-10-28 | Fmc公司 | 吡咯烷酮及其制备方法 |
-
2015
- 2015-12-01 EP EP15805092.2A patent/EP3230264B1/en active Active
- 2015-12-01 US US15/533,448 patent/US10227286B2/en active Active
- 2015-12-01 SG SG11201702924WA patent/SG11201702924WA/en unknown
- 2015-12-01 AU AU2015361018A patent/AU2015361018B2/en active Active
- 2015-12-01 PL PL15805092T patent/PL3230264T3/pl unknown
- 2015-12-01 KR KR1020177018406A patent/KR102542215B1/ko active IP Right Grant
- 2015-12-01 JP JP2017548361A patent/JP6611816B2/ja active Active
- 2015-12-01 RU RU2017123114A patent/RU2712831C2/ru active
- 2015-12-01 WO PCT/US2015/063101 patent/WO2016094117A1/en active Application Filing
- 2015-12-01 ES ES15805092T patent/ES2759267T3/es active Active
- 2015-12-01 MX MX2017007087A patent/MX2017007087A/es unknown
- 2015-12-01 BR BR112017009701-0A patent/BR112017009701B1/pt active IP Right Grant
- 2015-12-01 CN CN201580065080.1A patent/CN107001260B/zh active Active
- 2015-12-01 HU HUE15805092A patent/HUE047582T2/hu unknown
- 2015-12-04 TW TW104140692A patent/TWI694982B/zh active
- 2015-12-04 AR ARP150103996A patent/AR102939A1/es active IP Right Grant
-
2017
- 2017-06-04 IL IL252637A patent/IL252637A/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| TWI694982B (zh) | 2020-06-01 |
| SG11201702924WA (en) | 2017-05-30 |
| PL3230264T3 (pl) | 2020-03-31 |
| RU2017123114A3 (pt) | 2019-07-17 |
| ES2759267T3 (es) | 2020-05-08 |
| IL252637A0 (en) | 2017-07-31 |
| US20180057442A1 (en) | 2018-03-01 |
| EP3230264A1 (en) | 2017-10-18 |
| AU2015361018B2 (en) | 2020-01-16 |
| AU2015361018A1 (en) | 2017-04-27 |
| CN107001260A (zh) | 2017-08-01 |
| RU2017123114A (ru) | 2019-01-11 |
| IL252637A (en) | 2017-11-30 |
| KR20170090491A (ko) | 2017-08-07 |
| HUE047582T2 (hu) | 2020-05-28 |
| CN107001260B (zh) | 2020-11-10 |
| EP3230264B1 (en) | 2019-09-11 |
| JP2017538785A (ja) | 2017-12-28 |
| KR102542215B1 (ko) | 2023-06-12 |
| TW201632497A (zh) | 2016-09-16 |
| AR102939A1 (es) | 2017-04-05 |
| JP6611816B2 (ja) | 2019-11-27 |
| RU2712831C2 (ru) | 2020-02-03 |
| MX2017007087A (es) | 2017-09-05 |
| BR112017009701B1 (pt) | 2021-09-08 |
| US10227286B2 (en) | 2019-03-12 |
| WO2016094117A1 (en) | 2016-06-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BR112017009701A2 (pt) | composto e métodos para a preparação de um composto | |
| BR112017010354B8 (pt) | Compostos de triazolopirimidina, seu uso, e composição farmacêutica | |
| BR112017010893A2 (pt) | análogos de ácidos biliares como agonistas de fxr/tgr5 e métodos de uso dos mesmos | |
| BR112016025132A2 (pt) | compostos polifluorados agindo como inibidores de tirosina quinase de bruton | |
| CY1121602T1 (el) | Συνθεση της κοπανλισιμπης και του διυδροχλωρικου αλατος της | |
| EA201692219A1 (ru) | Способы получения противовирусных соединений | |
| BR112016029612A2 (pt) | compostos de di-hidroisoquinolinona substituídos | |
| ECSP15045801A (es) | Inhibidores de la phd de 6(5hidroxi1hpirazol1il)nicotinamida | |
| EA201691272A1 (ru) | Тетрагидропиридопиразины в качестве модуляторов gpr6 | |
| BR112017026132A2 (pt) | piridinas substituídas e métodos de uso | |
| BR112016029333A2 (pt) | síntese de compostos de carbamoilpiridona policíclico | |
| BR112016021282A8 (pt) | processos para a preparação de compostos antifúngicos e os referidos compostos | |
| EA201791058A1 (ru) | Морфолин- и 1,4-оксазепан-амиды в качестве агонистов соматостатинового рецептора подтипа 4 (sstr4) | |
| BR112018010140A8 (pt) | compostos de fórmula, composição, utilização de um composto de fórmula, método para o combate de fungos fitopatogênicos e semente | |
| BR112017028322A2 (pt) | compostos, processo para a produção de compostos i, para a produção de compostos ii dos compostos iii e para a produção de compostos iii, compostos intermediários v e utilização dos compostos i | |
| BR112016018851A8 (pt) | processo para fornecer um composto de fórmula (iv) | |
| BR112017011980A2 (pt) | composto, composição farmacêutica, e, método para tratar uma infecção bacteriana. | |
| UY36204A (es) | Derivados de insoindolina. | |
| BR112017000821A2 (pt) | novos compostos de pirimidina substituída. | |
| EA201790982A1 (ru) | Синтез копанлисиба и его дигидрохлорида | |
| BR112018010316A2 (pt) | compostos de fórmula, composição, utilização de um composto de fórmula, método para o combate de fungos fitopatogênicos e semente | |
| BR112018006545A2 (pt) | ?composto, composição farmacêutica, combinação, uso de um composto, e, método para tratamento de uma doença ou condição? | |
| BR112017015116A2 (pt) | derivados de (r)-2-metil-piperazina como moduladores do receptor cxcr3 | |
| BR112016029510A2 (pt) | métodos para a preparação de um composto, e, composto intermediário. | |
| BR112016022749A2 (pt) | compostos de azole substituído por amido como inibidores de tnks1 e/ou tnks2 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B25A | Requested transfer of rights approved |
Owner name: FMC CORPORATION (US) |
|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 3A ANUIDADE. |
|
| B08G | Application fees: restoration [chapter 8.7 patent gazette] | ||
| B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B350 | Update of information on the portal [chapter 15.35 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 01/12/2015, OBSERVADAS AS CONDICOES LEGAIS. |