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BR112016029510A2 - métodos para a preparação de um composto, e, composto intermediário. - Google Patents

métodos para a preparação de um composto, e, composto intermediário.

Info

Publication number
BR112016029510A2
BR112016029510A2 BR112016029510A BR112016029510A BR112016029510A2 BR 112016029510 A2 BR112016029510 A2 BR 112016029510A2 BR 112016029510 A BR112016029510 A BR 112016029510A BR 112016029510 A BR112016029510 A BR 112016029510A BR 112016029510 A2 BR112016029510 A2 BR 112016029510A2
Authority
BR
Brazil
Prior art keywords
compound
methods
preparing
intermediate compound
compounds
Prior art date
Application number
BR112016029510A
Other languages
English (en)
Inventor
Faldt André
METZLER Bjørn
Original Assignee
Leo Pharma As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Leo Pharma As filed Critical Leo Pharma As
Publication of BR112016029510A2 publication Critical patent/BR112016029510A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

a presente invenção refere-se a novos métodos para a preparação de compostos heterocíclicos de 1,3-benzodioxol e intermediários para o mesmo. os compostos são úteis como inibidores de pde4.
BR112016029510A 2014-06-23 2015-06-22 métodos para a preparação de um composto, e, composto intermediário. BR112016029510A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14173397 2014-06-23
PCT/EP2015/063942 WO2015197534A2 (en) 2014-06-23 2015-06-22 Methods for the preparation of 1,3-benzodioxole heterocyclic compounds

Publications (1)

Publication Number Publication Date
BR112016029510A2 true BR112016029510A2 (pt) 2017-08-22

Family

ID=50980952

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112016029510A BR112016029510A2 (pt) 2014-06-23 2015-06-22 métodos para a preparação de um composto, e, composto intermediário.

Country Status (18)

Country Link
US (1) US9908894B2 (pt)
EP (1) EP3157930B1 (pt)
JP (1) JP6785666B2 (pt)
KR (1) KR20170016894A (pt)
CN (1) CN106459081B (pt)
AU (1) AU2015279428B2 (pt)
BR (1) BR112016029510A2 (pt)
CA (1) CA2953284A1 (pt)
DK (1) DK3157930T3 (pt)
ES (1) ES2702451T3 (pt)
IL (1) IL249336A0 (pt)
MX (1) MX2016016378A (pt)
PL (1) PL3157930T3 (pt)
PT (1) PT3157930T (pt)
RU (1) RU2697251C2 (pt)
TW (1) TW201613934A (pt)
WO (1) WO2015197534A2 (pt)
ZA (1) ZA201608442B (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114085234A (zh) 2015-12-18 2022-02-25 联合疗法公司 用于制备1,3-苯并间二氧杂环戊烯杂环化合物的方法
KR102676384B1 (ko) * 2017-06-20 2024-06-20 유니온 테라퓨틱스 에이/에스 1,3-벤조디옥솔 헤테로시클릭 화합물의 제조방법
ES2935615T3 (es) 2017-12-15 2023-03-08 Union Therapeutics As Azetidina dihidrotienopiridinas sustituidas y su uso como inhibidores de la fosfodiesterasa
USD914676S1 (en) 2018-05-11 2021-03-30 Samsung Electronics Co., Ltd. Notebook computer
EA202191955A1 (ru) 2019-01-15 2021-10-07 Юнион Терапьютикс А/С Таблетированные составы с модифицированным высвобождением, содержащие ингибиторы фосфодиэстеразы
AU2022245186A1 (en) 2021-03-22 2023-10-05 UNION therapeutics A/S Treatment of hidradenitis suppurativa with orismilast
GB202205715D0 (en) 2022-04-19 2022-06-01 Union Therapeutics As Treatment of neutrophilic dermatoses

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6514996B2 (en) * 1995-05-19 2003-02-04 Kyowa Hakko Kogyo Co., Ltd. Derivatives of benzofuran or benzodioxole
ATE325110T1 (de) * 1995-05-19 2006-06-15 Kyowa Hakko Kogyo Kk Sauerstoff enthaltende heterocyclische verbindungen
DE10205274A1 (de) * 2002-02-08 2003-08-21 Boehringer Ingelheim Pharma Neue Arzneimittelkompositionen enthaltend neben Anticholinergika heterocyclische Verbindungen
JPWO2004005276A1 (ja) * 2002-07-03 2005-11-04 協和醗酵工業株式会社 １，３−ベンゾジオキソール−２−スピロシクロアルカン誘導体の製造法
CN101490004B (zh) * 2006-07-14 2012-01-11 奇斯药制品公司 作为磷酸二酯酶抑制剂的1-苯基-2-吡啶基烯基醇的衍生物
BRPI0721113A2 (pt) * 2006-12-22 2014-10-07 Leo Pharma As Composto, composição farmacêutica, uso de um composto, e, método para prevenir, tratar ou melhorar doenças ou condições dérmicas ou distúrbios
ZA200905371B (en) * 2007-02-28 2010-10-27 Leo Pharma As Novel phosphodiesterase Inhibitors
RU2495043C2 (ru) 2007-02-28 2013-10-10 Лео Фарма А/С Новые ингибиторы фосфодиэстераз
EP2585469B1 (en) * 2010-06-24 2016-05-25 Leo Pharma A/S Benzodioxole or benzodioxepine heterocyclic compounds as phosphodiesterase inhibitors
WO2014096018A1 (en) * 2012-12-19 2014-06-26 Leo Pharma A/S Methods for the preparation of substituted acetophenones
CN114085234A (zh) * 2015-12-18 2022-02-25 联合疗法公司 用于制备1,3-苯并间二氧杂环戊烯杂环化合物的方法

Also Published As

Publication number Publication date
TW201613934A (en) 2016-04-16
ES2702451T3 (es) 2019-03-01
PL3157930T3 (pl) 2019-04-30
US9908894B2 (en) 2018-03-06
EP3157930B1 (en) 2018-10-17
CN106459081B (zh) 2019-09-10
CA2953284A1 (en) 2015-12-30
RU2017101808A (ru) 2018-07-27
MX2016016378A (es) 2017-10-16
JP6785666B2 (ja) 2020-11-18
CN106459081A (zh) 2017-02-22
AU2015279428B2 (en) 2018-02-15
JP2017520547A (ja) 2017-07-27
RU2697251C2 (ru) 2019-08-13
WO2015197534A2 (en) 2015-12-30
DK3157930T3 (en) 2019-01-21
WO2015197534A3 (en) 2016-03-17
RU2017101808A3 (pt) 2019-01-22
EP3157930A2 (en) 2017-04-26
US20170137438A1 (en) 2017-05-18
ZA201608442B (en) 2018-05-30
AU2015279428A1 (en) 2017-01-05
PT3157930T (pt) 2018-12-24
KR20170016894A (ko) 2017-02-14
IL249336A0 (en) 2017-02-28

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Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 5A ANUIDADE.

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2594 DE 24-09-2020 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.