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BR112015021429A2 - compostos antivirais - Google Patents

compostos antivirais

Info

Publication number
BR112015021429A2
BR112015021429A2 BR112015021429A BR112015021429A BR112015021429A2 BR 112015021429 A2 BR112015021429 A2 BR 112015021429A2 BR 112015021429 A BR112015021429 A BR 112015021429A BR 112015021429 A BR112015021429 A BR 112015021429A BR 112015021429 A2 BR112015021429 A2 BR 112015021429A2
Authority
BR
Brazil
Prior art keywords
compounds
antiviral compounds
formula
antiviral
variables
Prior art date
Application number
BR112015021429A
Other languages
English (en)
Inventor
Jiang Nan
Ding Qingjie
James Weikert Robert
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BR112015021429A2 publication Critical patent/BR112015021429A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/14—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Epidemiology (AREA)

Abstract

1/1 resumo compostos antivirais a presente invenção expõe compostos da fórmula i: h nnnhnnhar1n i em que as variáveis na formula i são definidas da forma que se encontra descrita neste contexto. expõem-se também composições farmacêuticas que contêm esses compostos e métodos para a utilização dos compostos da fórmula i na prevenção ou tratamento de infecção por hcv.
BR112015021429A 2013-03-05 2014-02-27 compostos antivirais BR112015021429A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361772924P 2013-03-05 2013-03-05
PCT/EP2014/053780 WO2014135422A1 (en) 2013-03-05 2014-02-27 Antiviral compounds

Publications (1)

Publication Number Publication Date
BR112015021429A2 true BR112015021429A2 (pt) 2017-07-18

Family

ID=50280353

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112015021429A BR112015021429A2 (pt) 2013-03-05 2014-02-27 compostos antivirais

Country Status (11)

Country Link
US (1) US9428469B2 (pt)
EP (1) EP2964637B1 (pt)
JP (1) JP6018715B2 (pt)
KR (1) KR20150114566A (pt)
CN (1) CN105008350B (pt)
BR (1) BR112015021429A2 (pt)
CA (1) CA2900319A1 (pt)
HK (1) HK1216885A1 (pt)
MX (1) MX2015011193A (pt)
RU (1) RU2015136256A (pt)
WO (1) WO2014135422A1 (pt)

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Publication number Priority date Publication date Assignee Title
BR112015020952A2 (pt) * 2013-03-06 2017-07-18 Hoffmann La Roche compostos antivirais
CN106467501B (zh) * 2015-08-18 2018-10-26 中国医学科学院医药生物技术研究所 新型抗病毒化合物
JP6848504B2 (ja) * 2017-02-15 2021-03-24 株式会社村田製作所 二次電池用電解液、二次電池、電池パック、電動車両、電力貯蔵システム、電動工具および電子機器
US11066404B2 (en) 2018-10-11 2021-07-20 Incyte Corporation Dihydropyrido[2,3-d]pyrimidinone compounds as CDK2 inhibitors
US11384083B2 (en) 2019-02-15 2022-07-12 Incyte Corporation Substituted spiro[cyclopropane-1,5′-pyrrolo[2,3-d]pyrimidin]-6′(7′h)-ones as CDK2 inhibitors
CN111621026A (zh) * 2019-02-28 2020-09-04 南京农业大学 一种双功能钴配合物材料的制备方法及其电化学性能应用
WO2020180959A1 (en) 2019-03-05 2020-09-10 Incyte Corporation Pyrazolyl pyrimidinylamine compounds as cdk2 inhibitors
WO2020205560A1 (en) 2019-03-29 2020-10-08 Incyte Corporation Sulfonylamide compounds as cdk2 inhibitors
US11440914B2 (en) 2019-05-01 2022-09-13 Incyte Corporation Tricyclic amine compounds as CDK2 inhibitors
US11447494B2 (en) 2019-05-01 2022-09-20 Incyte Corporation Tricyclic amine compounds as CDK2 inhibitors
WO2021030537A1 (en) 2019-08-14 2021-02-18 Incyte Corporation Imidazolyl pyrimidinylamine compounds as cdk2 inhibitors
JOP20220087A1 (ar) 2019-10-11 2023-01-30 Incyte Corp أمينات ثنائية الحلقة كمثبطات لـ cdk2
EP4125861A4 (en) * 2020-04-03 2024-07-10 Univ California PROTEIN-PROTEIN INTERACTION STABILIZERS
US11981671B2 (en) 2021-06-21 2024-05-14 Incyte Corporation Bicyclic pyrazolyl amines as CDK2 inhibitors
US11976073B2 (en) 2021-12-10 2024-05-07 Incyte Corporation Bicyclic amines as CDK2 inhibitors

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Also Published As

Publication number Publication date
JP2016510046A (ja) 2016-04-04
CA2900319A1 (en) 2014-09-12
EP2964637B1 (en) 2017-04-12
US9428469B2 (en) 2016-08-30
MX2015011193A (es) 2015-11-13
HK1216885A1 (zh) 2016-12-09
US20160009666A1 (en) 2016-01-14
CN105008350A (zh) 2015-10-28
RU2015136256A (ru) 2017-04-10
EP2964637A1 (en) 2016-01-13
WO2014135422A1 (en) 2014-09-12
CN105008350B (zh) 2018-05-08
JP6018715B2 (ja) 2016-11-02
KR20150114566A (ko) 2015-10-12

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Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal acc. article 33 of ipl - extension of time limit for request of examination expired