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BR0309671A - ácidos de piperidinil- e piperazinil-sulfonilmetil hidroxâmicos e seu uso como inibidores de protease - Google Patents

ácidos de piperidinil- e piperazinil-sulfonilmetil hidroxâmicos e seu uso como inibidores de protease

Info

Publication number
BR0309671A
BR0309671A BR0309671-8A BR0309671A BR0309671A BR 0309671 A BR0309671 A BR 0309671A BR 0309671 A BR0309671 A BR 0309671A BR 0309671 A BR0309671 A BR 0309671A
Authority
BR
Brazil
Prior art keywords
hydroxamic acids
piperazinyl
piperidinyl
activity
acids
Prior art date
Application number
BR0309671-8A
Other languages
English (en)
Inventor
Thomas E Barta
Daniel P Becker
Louis J Bedell
Terri L Boehm
David L Brown
Jeffery N Carroll
Yiyuan Chen
Yvette Fobian
John N Freskos
Alan F Gasiecki
Margaret Grapperhaus
Robert M Heintz
Susan L Hockerman
Darren J Kassab
Stephen A Kolodziej
Mark Massa
Joseph Mcdonald
Brent V Mischke
Deborah A Mischke
Patrick B Mullins
Mark Nagy
Monica B Norton
Joseph G Rico
Michelle A Schmidt
Nathan W Stehle
John J Talley
William F Vernier
Clara I Villamill
Lijuan Jane Wang
Thomas A Wynn
Ish Kumar Khanna
Original Assignee
Pharmacia Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Corp filed Critical Pharmacia Corp
Publication of BR0309671A publication Critical patent/BR0309671A/pt

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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
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Abstract

"áCIDOS DE PIPERIDINIL- E PIPERAZINIL-SULFONILMETIL HIDROXâMICOS E SEU USO COMO INIBIDORES DE PROTEASE". Esta invenção refere-se geralmente aos inibidores de proteinase (também conhecida como 'protease'), e, mais particularmente, aos ácidos piperidinil- e piperazinil-sulfonilmetil hidroxâmicos que, entre outras coisas, inibem a atividade de metaloproteinase de matriz (também conhecida como 'metaloprotease de matriz' ou 'MMP') e/ou atividade de agrecanase. Tais ácidos hidroxâmicos geralmente correspondem em estrutura à seguinte fórmula (I), (em que A^ 1^, A^ 2^, Y, E^ 1^, E^ 2^, E^ 3^, e R^ x^ são como definido neste relatório descritivo), e também incluem sais de tais compostos. Esta invenção também se refere às composições de tais ácidos hidroxâmicos, intermediários para a síntese de tais ácidos hidroxâmicos, métodos para preparar tais ácidos hidroxâmicos, e métodos para tratar condições (particularmente condições patológicas) associadas com a atividade MMP e/ou atividade de agrecanase.
BR0309671-8A 2002-04-25 2003-04-25 ácidos de piperidinil- e piperazinil-sulfonilmetil hidroxâmicos e seu uso como inibidores de protease BR0309671A (pt)

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PCT/US2003/013123 WO2003091247A2 (en) 2002-04-25 2003-04-25 Piperidinyl-and piperazinyl-sulfonylmethyl hydroxamic acids and their use as protease inhibitors

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