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BR0207502A - Compostos, enanciÈmeros, composição farmacêutica, uso de compostos, e, processo para a fabricação de compostos - Google Patents

Compostos, enanciÈmeros, composição farmacêutica, uso de compostos, e, processo para a fabricação de compostos

Info

Publication number
BR0207502A
BR0207502A BR0207502-4A BR0207502A BR0207502A BR 0207502 A BR0207502 A BR 0207502A BR 0207502 A BR0207502 A BR 0207502A BR 0207502 A BR0207502 A BR 0207502A
Authority
BR
Brazil
Prior art keywords
compounds
pharmaceutical composition
medicines
manufacturing
amino acid
Prior art date
Application number
BR0207502-4A
Other languages
English (en)
Inventor
Daniel Obrecht
John Anthony Robinson
Jan Wim Vrijbloed
Original Assignee
Polyphor Ltd
Universitot Z Rich
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Polyphor Ltd, Universitot Z Rich filed Critical Polyphor Ltd
Publication of BR0207502A publication Critical patent/BR0207502A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/047—Simultaneous synthesis of different peptide species; Peptide libraries
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
  • Cosmetics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

"COMPOSTOS, ENANCIÈMEROS, COMPOSIçãO FARMACêUTICA, USO DE COMPOSTOS, E, PROCESSO PARA A FABRICAçãO DE COMPOSTOS". Os peptidomiméticos de <225>-hairpin de padrão fixo das fórmulas gerais (I) e (II) em que Z, Z^ 1^ e Z^ 2^ são cadeias de padrão fixo de 8 a 16 resíduos de <244>-aminoácido que, dependendo de suas posições na cadeia (contados a partir do aminoácido de terminal N) são Gly ou Pro ou de certos tipos que, como os símbolos remanescentes nas fórmulas acima, são definidos na descrição e nas reivindicações e seus sais, tem a propriedade de inibir o desenvolvimento ou matar microorganismos e células cancerígenas. Estes podem ser usados como desinfetantes para gêneros alimentícios, cosméticos, medicamentos ou outros materiais contendo nutrientes ou como medicamentos para tratar ou prevenir infeções ou doenças relacionadas com tais infeções e/ou câncer. Estes peptidomiméticos de <225>-hairpin podem ser fabricados por um processo que está fundamentado em uma estratégia sintética de fase sólida ou de solução mista.
BR0207502-4A 2001-02-23 2002-02-18 Compostos, enanciÈmeros, composição farmacêutica, uso de compostos, e, processo para a fabricação de compostos BR0207502A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP0102072 2001-02-23
PCT/EP2002/001711 WO2002070547A1 (en) 2001-02-23 2002-02-18 Template-fixed peptidomimetics with antimicrobial activity

Publications (1)

Publication Number Publication Date
BR0207502A true BR0207502A (pt) 2004-03-09

Family

ID=8164309

Family Applications (2)

Application Number Title Priority Date Filing Date
BR0207502-4A BR0207502A (pt) 2001-02-23 2002-02-18 Compostos, enanciÈmeros, composição farmacêutica, uso de compostos, e, processo para a fabricação de compostos
BRPI0207502A BRPI0207502B1 (pt) 2001-02-23 2002-02-18 compostos, enanciômeros, composição farmacêutica, uso de compostos, e, processo para a fabricação de compostos

Family Applications After (1)

Application Number Title Priority Date Filing Date
BRPI0207502A BRPI0207502B1 (pt) 2001-02-23 2002-02-18 compostos, enanciômeros, composição farmacêutica, uso de compostos, e, processo para a fabricação de compostos

Country Status (10)

Country Link
US (1) US7253146B2 (pt)
EP (1) EP1363934B1 (pt)
JP (1) JP4310106B2 (pt)
CN (1) CN1255428C (pt)
AU (1) AU2002247724B2 (pt)
BR (2) BR0207502A (pt)
CA (1) CA2439178C (pt)
ES (1) ES2527339T3 (pt)
HK (1) HK1064391A1 (pt)
WO (1) WO2002070547A1 (pt)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1532164B1 (en) * 2002-08-20 2012-09-26 Polyphor Ltd. Template-fixed peptidomimetics with antibacterial activity
US7855179B2 (en) 2002-10-02 2010-12-21 Polyphor Ltd. Template-fixed peptidomimetics with antimicrobial activity
EP1549670B1 (en) * 2002-10-02 2008-04-30 Polyphor Ltd. Template-fixed peptidomimetics with antimicrobial activity
DE60321053D1 (de) 2003-05-02 2008-06-26 Polyphor Ag Matrizenfixierte peptidmimetika als medikamente gegen hiv und krebs
WO2004096839A1 (en) * 2003-05-02 2004-11-11 Polyphor Ag Template-fixed beta-hairpin peptidomimetics with cxcr4 antagonizing activity
ATE457995T1 (de) 2003-06-18 2010-03-15 Tranzyme Pharma Inc Makrozyklische motilin rezeptorantagonisten
DK1689863T3 (da) * 2003-11-15 2014-08-25 Polyphor Ltd Template-fikserede beta-hairpinloopmimetika og deres anvendelse i fag-display
NZ556747A (en) * 2005-02-17 2009-09-25 Polyphor Ltd Template-fixed beta-hairpin peptidomimetics with protease inhibitory acitivity
WO2007079597A1 (en) * 2006-01-16 2007-07-19 Polyphor Ltd. Template - fixed peptidomimetics with antimicrobial activity
CN101668421B (zh) 2006-11-16 2014-05-21 凯制药公司 用于治疗甲状旁腺功能亢进和高钙血症的聚阳离子钙调节肽
US8633163B2 (en) * 2007-01-29 2014-01-21 Polyphor Ltd. Template-fixed peptidomimetics
WO2008095063A1 (en) 2007-01-31 2008-08-07 Dana-Farber Cancer Institute, Inc. Stabilized p53 peptides and uses thereof
ES2349879T3 (es) * 2007-02-28 2011-01-12 Polyphor Ltd. Peptidomiméticos fijados sobre patrón.
KR101623985B1 (ko) 2007-03-28 2016-05-25 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 스티칭된 폴리펩티드
ES2537634T3 (es) 2008-08-08 2015-06-10 Polyphor Ag Peptidomiméticos fijados por plantilla
WO2010060479A1 (en) * 2008-11-26 2010-06-03 Polyphor Ag Template-fixed beta-hairpin peptidomimetics with cxcr4 antagonizing activity
PL2459208T3 (pl) 2009-07-29 2017-05-31 Kai Pharmaceuticals, Inc. Środki lecznicze zmniejszające poziom parathormonu
US8895499B2 (en) 2010-08-05 2014-11-25 Polyphor Ag β-hairpin peptidomimetics
WO2012021875A1 (en) 2010-08-13 2012-02-16 Aileron Therapeutics, Inc. Peptidomimetic macrocycles with triazole linkers
RS55503B1 (sr) 2011-06-08 2017-05-31 Kai Pharmaceuticals Inc Terapijska sredstva za regulisanje fosfora u serumu
CN103842373B (zh) 2011-10-07 2018-12-21 波利弗尔股份公司 模板-固定的肽模拟物作为fpr1的抑制物
CN108929375A (zh) 2011-10-18 2018-12-04 爱勒让治疗公司 拟肽大环化合物
WO2013123267A1 (en) 2012-02-15 2013-08-22 Aileron Therapeutics, Inc. Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles
RU2642299C2 (ru) 2012-02-15 2018-01-24 Эйлерон Терапьютикс, Инк. P53 пептидомиметические макроциклы
DK2882770T3 (en) 2012-08-08 2017-09-18 Polyphor Ag COMBINATIONS WITH A BACKBONE CYCLIZED PEPTID
AU2012387696B2 (en) * 2012-08-15 2017-09-21 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Anti-microbial activity of synthetic peptides
CA2887285A1 (en) 2012-11-01 2014-05-08 Aileron Therapeutics, Inc. Disubstituted amino acids and methods of preparation and use thereof
CN105324390B (zh) * 2013-03-30 2021-10-19 波利弗尔股份公司 β-发夹肽模拟物
KR102279427B1 (ko) * 2013-03-30 2021-07-20 폴리포 리미티드 Beta-헤어핀 펩타이드 모방체
CA2961029A1 (en) 2014-09-24 2016-03-31 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and formulations thereof
SG11201702223UA (en) 2014-09-24 2017-04-27 Aileron Therapeutics Inc Peptidomimetic macrocycles and uses thereof
EP3201219B1 (en) 2014-09-30 2021-11-17 Polyphor Ag Beta-hairpin peptidomimetics
US10259847B2 (en) 2014-09-30 2019-04-16 Polyphor Ag Beta-hairpin peptidomimetics
MX2017011834A (es) 2015-03-20 2018-04-11 Aileron Therapeutics Inc Macrociclos peptidomimeticos y usos de los mismos.
CN107636007A (zh) 2015-03-23 2018-01-26 波利弗尔股份公司 β‑发夹肽模拟物
CA2982869C (en) * 2015-04-09 2021-06-15 Isp Investments Llc Synergistic preservative compositions
US10023613B2 (en) 2015-09-10 2018-07-17 Aileron Therapeutics, Inc. Peptidomimetic macrocycles as modulators of MCL-1
JP7312167B2 (ja) 2017-11-10 2023-07-20 スペクシス アーゲー ベータヘアピンペプチド模倣物
EP4063380A1 (en) * 2021-03-24 2022-09-28 Stichting VU Inhibitors of the wnt signaling pathway and uses thereof
WO2023227771A1 (en) 2022-05-27 2023-11-30 Fundación Privada Instituto De Salud Global Barcelona Cyclic peptides with antibacterial activity against multidrug resistant (mdr) pathogens

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4698327A (en) * 1985-04-25 1987-10-06 Eli Lilly And Company Novel glycopeptide derivatives
US5916872A (en) * 1996-07-24 1999-06-29 Intrabiotics Pharmaceuticals, Inc. Cyclic peptides having broad spectrum antimicrobial activity
US6878804B1 (en) * 1999-08-30 2005-04-12 University Of Zurich Synthesis of template-fixed β-hairpin loop mimetics

Also Published As

Publication number Publication date
US7253146B2 (en) 2007-08-07
CA2439178C (en) 2013-06-04
CA2439178A1 (en) 2002-09-12
AU2002247724B2 (en) 2008-02-07
EP1363934B1 (en) 2014-10-08
US20040171066A1 (en) 2004-09-02
WO2002070547A8 (en) 2003-10-30
JP2004534738A (ja) 2004-11-18
BRPI0207502B1 (pt) 2018-10-09
JP4310106B2 (ja) 2009-08-05
HK1064391A1 (en) 2005-01-28
CN1498225A (zh) 2004-05-19
EP1363934A1 (en) 2003-11-26
ES2527339T3 (es) 2015-01-23
CN1255428C (zh) 2006-05-10
WO2002070547A1 (en) 2002-09-12

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A(S) 6A ANUIDADE(S)

B08G Application fees: restoration [chapter 8.7 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 09/10/2018, OBSERVADAS AS CONDICOES LEGAIS.

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

Free format text: REFERENTE A 18A ANUIDADE.

B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)

Free format text: REFERENTE AO DESPACHO 21.6 PUBLICADO NA RPI 2554 DE 2019-12-17