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BR0014652A - Fabricação de conjugados de agente terapêutico-poliglutamato - Google Patents

Fabricação de conjugados de agente terapêutico-poliglutamato

Info

Publication number
BR0014652A
BR0014652A BR0014652-8A BR0014652A BR0014652A BR 0014652 A BR0014652 A BR 0014652A BR 0014652 A BR0014652 A BR 0014652A BR 0014652 A BR0014652 A BR 0014652A
Authority
BR
Brazil
Prior art keywords
therapeutic agent
manufacture
conjugates
polyglutamate
polyglutamate conjugates
Prior art date
Application number
BR0014652-8A
Other languages
English (en)
Other versions
BRPI0014652B1 (pt
Inventor
Anil M Kumar
J Peter Klein
Rama Bhatt
Edward Vanter
Original Assignee
Cell Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cell Therapeutics Inc filed Critical Cell Therapeutics Inc
Publication of BR0014652A publication Critical patent/BR0014652A/pt
Publication of BRPI0014652B1 publication Critical patent/BRPI0014652B1/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Polyamides (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Peptides Or Proteins (AREA)

Abstract

"FABRICAçãO DE CONJUGADOS DE AGENTE TERAPêUTICO-POLIGLUTAMATO". A invenção provê novos processos para preparação de conjugados de agente terapêutico e ácido poliglutâmico para desenvolvimento clínico e uso farmacêutico e conjugados de agente terapêutico-ácido poliglutâmico preparados de acordo com estes processos.
BRPI0014652A 1999-10-12 2000-10-12 fabricação de conjugados de agente terapêutico-poliglutamato BRPI0014652B1 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15913599P 1999-10-12 1999-10-12
PCT/US2000/028109 WO2001026693A2 (en) 1999-10-12 2000-10-12 Manufacture of polyglutamate-therapeutic agent conjugates

Publications (2)

Publication Number Publication Date
BR0014652A true BR0014652A (pt) 2003-06-10
BRPI0014652B1 BRPI0014652B1 (pt) 2016-08-09

Family

ID=22571222

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0014652A BRPI0014652B1 (pt) 1999-10-12 2000-10-12 fabricação de conjugados de agente terapêutico-poliglutamato

Country Status (16)

Country Link
US (2) US20020077279A1 (pt)
EP (2) EP1225917A2 (pt)
JP (1) JP2003511423A (pt)
KR (1) KR100821437B1 (pt)
CN (2) CN1607962A (pt)
AU (1) AU781735B2 (pt)
BR (1) BRPI0014652B1 (pt)
CA (1) CA2387611C (pt)
HU (1) HUP0203123A3 (pt)
MX (1) MXPA02003719A (pt)
NO (1) NO20021701L (pt)
NZ (1) NZ529789A (pt)
PL (1) PL354623A1 (pt)
SG (1) SG147286A1 (pt)
WO (1) WO2001026693A2 (pt)
ZA (1) ZA200202695B (pt)

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US7259156B2 (en) 2004-05-20 2007-08-21 Kosan Biosciences Incorporated Geldanamycin compounds and method of use
US8614228B2 (en) 2004-08-11 2013-12-24 Arqule, Inc. Quinone prodrug compositions and methods of use
US7812051B2 (en) 2004-08-11 2010-10-12 Arqule, Inc. Pharmaceutical compositions of β-lapachone and β-lapachone analogs with improved tumor targeting potential
EP1792927B1 (en) 2004-09-22 2013-03-06 Nippon Kayaku Kabushiki Kaisha Novel block copolymer, micelle preparation, and anticancer agent containing the same as active ingredient
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JP5249016B2 (ja) 2006-03-28 2013-07-31 日本化薬株式会社 タキサン類の高分子結合体
CN101448875A (zh) 2006-05-18 2009-06-03 日本化药株式会社 鬼臼毒素类的高分子量结合体
WO2008056596A1 (en) 2006-11-06 2008-05-15 Nippon Kayaku Kabushiki Kaisha Polymeric derivative of nucleic acid metabolic antagonist
US8188222B2 (en) 2006-11-08 2012-05-29 Nippon Kayaku Kabushiki Kaisha High molecular weight derivative of nucleic acid antimetabolite
CN101209350B (zh) * 2006-12-30 2011-09-07 中国人民解放军军事医学科学院毒物药物研究所 以氨基酸为连接子的多聚谷氨酸-药物偶合物
AU2008213576B2 (en) * 2007-02-09 2013-01-17 Enzon Pharmaceuticals, Inc. Treatment of resistant or refractory cancers with multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamptothecin
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AU2008246067B2 (en) 2007-04-30 2011-10-20 Arqule, Inc. Hydroxy sulfonate of quinone compounds and their uses
CN101707869A (zh) * 2007-05-09 2010-05-12 日东电工株式会社 具有多种药物的聚谷氨酸盐结合物和聚谷氨酸盐-氨基酸结合物
EP2155254B1 (en) * 2007-05-09 2012-11-28 Nitto Denko Corporation Polymers conjugated with platinum drugs
JP5341879B2 (ja) * 2007-05-09 2013-11-13 日東電工株式会社 疎水性化合物及びポリアミノ酸複合体を含む組成物
EP2206502B1 (en) 2007-09-28 2018-09-12 Nippon Kayaku Kabushiki Kaisha Polymer conjugate of steroid
EP2262537A1 (en) * 2008-03-06 2010-12-22 Nitto Denko Corporation Polymer paclitaxel conjugates and methods for treating cancer
WO2009116509A1 (ja) 2008-03-18 2009-09-24 日本化薬株式会社 生理活性物質の高分子結合体
US9149540B2 (en) 2008-05-08 2015-10-06 Nippon Kayaku Kabushiki Kaisha Polymer conjugate of folic acid or folic acid derivative
US20100056555A1 (en) * 2008-08-29 2010-03-04 Enzon Pharmaceuticals, Inc. Method of treating ras associated cancer
CN102264396A (zh) 2008-10-07 2011-11-30 瑞沙恩医药公司 Hpma-多西他赛或吉西他滨缀合物及其用途
US20100093935A1 (en) * 2008-10-15 2010-04-15 Nitto Denko Corporation Method of preparing polyglutamate conjugates
CN102215688A (zh) * 2008-10-21 2011-10-12 安龙制药公司 用7-乙基-10-羟基喜树碱的多臂聚合物对神经母细胞瘤的治疗
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CN102686243B (zh) 2009-10-13 2015-02-18 瑞沙恩医药公司 用于抗癌剂递送的聚合物系统
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TW201304805A (zh) 2010-11-17 2013-02-01 Nippon Kayaku Kk 新穎之胞核苷系代謝拮抗劑之高分子衍生物
CN102649810A (zh) * 2011-05-19 2012-08-29 东北林业大学 喜树碱衍生物、其制备方法和用途
US8691284B2 (en) 2011-07-07 2014-04-08 Empire Technology Development Llc Fluorinated block co-polymers
EP2754682B1 (en) 2011-09-11 2017-06-07 Nippon Kayaku Kabushiki Kaisha Method for manufacturing block copolymer
US8383093B1 (en) 2011-11-01 2013-02-26 Serina Therapeutics, Inc. Subcutaneous delivery of poly(oxazoline) conjugates
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CN105143244A (zh) 2013-04-26 2015-12-09 日东电工株式会社 降低多聚阴离子聚合物偶联物中的内毒素
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CN106267227A (zh) * 2016-08-12 2017-01-04 北京蓝贝望生物医药科技股份有限公司 抗肿瘤药物
CN106750272B (zh) * 2016-12-05 2019-05-28 福建卫生职业技术学院 一种水溶性蛇葡萄素聚合物
CN110123748A (zh) * 2019-04-22 2019-08-16 南京师范大学 一种叶酸介导的靶向双载药聚合物胶束及其制备方法和应用
CN113773282A (zh) * 2021-09-22 2021-12-10 无锡紫杉药业有限公司 一种10-乙酰紫杉醇的制备方法

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Also Published As

Publication number Publication date
US7399860B2 (en) 2008-07-15
AU781735B2 (en) 2005-06-09
NZ529789A (en) 2005-04-29
NO20021701L (no) 2002-05-23
KR20020059616A (ko) 2002-07-13
BRPI0014652B1 (pt) 2016-08-09
EP1466627A1 (en) 2004-10-13
HUP0203123A2 (hu) 2003-01-28
CN101507820A (zh) 2009-08-19
ZA200202695B (en) 2004-02-25
SG147286A1 (en) 2008-11-28
PL354623A1 (en) 2004-02-09
US20020077279A1 (en) 2002-06-20
WO2001026693A3 (en) 2001-12-27
CN1607962A (zh) 2005-04-20
HUP0203123A3 (en) 2004-12-28
US20030224971A1 (en) 2003-12-04
JP2003511423A (ja) 2003-03-25
MXPA02003719A (es) 2002-08-30
WO2001026693A2 (en) 2001-04-19
CA2387611A1 (en) 2001-04-19
CA2387611C (en) 2011-03-29
AU1079301A (en) 2001-04-23
EP1225917A2 (en) 2002-07-31
KR100821437B1 (ko) 2008-04-10
NO20021701D0 (no) 2002-04-11

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Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 09/08/2016, OBSERVADAS AS CONDICOES LEGAIS.

B15K Others concerning applications: alteration of classification

Ipc: A61K 47/64 (2017.01)

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time
B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)

Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2483 DE 07-08-2018 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.