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BR0013613A - Preparação farmaceuticamente estável de oxaliplatina para administração parenteral - Google Patents

Preparação farmaceuticamente estável de oxaliplatina para administração parenteral

Info

Publication number
BR0013613A
BR0013613A BR0013613-1A BR0013613A BR0013613A BR 0013613 A BR0013613 A BR 0013613A BR 0013613 A BR0013613 A BR 0013613A BR 0013613 A BR0013613 A BR 0013613A
Authority
BR
Brazil
Prior art keywords
parenteral administration
oxaliplatin
pharmaceutically stable
preparation
stable preparation
Prior art date
Application number
BR0013613-1A
Other languages
English (en)
Other versions
BRPI0013613B8 (pt
BR0013613B1 (pt
Inventor
Houssam Ibrahim
Martine Bayssas
Henri Pourrat
Christine Deuschel
Original Assignee
Debiopharm Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Debiopharm Sa filed Critical Debiopharm Sa
Publication of BR0013613A publication Critical patent/BR0013613A/pt
Publication of BR0013613B1 publication Critical patent/BR0013613B1/pt
Publication of BRPI0013613B8 publication Critical patent/BRPI0013613B8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/243—Platinum; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Dermatology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Abstract

Patente de Invenção para "PREPARAçãO FARMACEUTICAMENTE ESTáVEL DE OXALIPLATINA PARA ADMINISTRAçãO PARENTERAL". A invenção se refere a uma preparação farmaceuticamente estável de oxaliplatina para administração parenteral, a oxaliplatina estando em uma solução clara e incolor, em um precipitado livre, após ser preservada para uma duração farmaceuticamente aceitável. Na referida preparação, a oxaliplatina está contida em uma solução em um solvente em uma concentração de pelo menos 7 mg/ml e o solvente compreende uma quantidade suficiente de pelo menos um derivado hidroxilado selecionado dentre 1,2-propanodiol, glicerol, maltitol, sacarose e inositol. A invenção também se refere a um método para preparar a referida solução.
BRPI0013613A 1999-08-30 2000-08-30 composição farmacêuticamente estável de oxaliplatina para administração parenteral. BRPI0013613B8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15135799P 1999-08-30 1999-08-30
PCT/CH2000/000462 WO2001015691A1 (fr) 1999-08-30 2000-08-30 Preparation pharmaceutique stable d'oxaliplatine pour administration par voie parenterale

Publications (3)

Publication Number Publication Date
BR0013613A true BR0013613A (pt) 2002-05-14
BR0013613B1 BR0013613B1 (pt) 2013-05-28
BRPI0013613B8 BRPI0013613B8 (pt) 2021-05-25

Family

ID=22538394

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0013613A BRPI0013613B8 (pt) 1999-08-30 2000-08-30 composição farmacêuticamente estável de oxaliplatina para administração parenteral.

Country Status (19)

Country Link
EP (1) EP1207875B1 (pt)
JP (1) JP4890711B2 (pt)
KR (1) KR100688217B1 (pt)
CN (1) CN1170533C (pt)
AT (1) ATE249825T1 (pt)
AU (1) AU768169B2 (pt)
BR (1) BRPI0013613B8 (pt)
CA (1) CA2382389C (pt)
CZ (1) CZ298581B6 (pt)
DE (1) DE60005376T2 (pt)
DK (1) DK1207875T3 (pt)
ES (1) ES2206288T3 (pt)
HK (1) HK1048266B (pt)
MX (1) MXPA02002266A (pt)
PT (1) PT1207875E (pt)
RU (1) RU2252022C2 (pt)
UA (1) UA71985C2 (pt)
WO (1) WO2001015691A1 (pt)
ZA (1) ZA200200800B (pt)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002223013A1 (en) * 2000-12-12 2002-06-24 Debiopharm S.A. Pharmaceutical oxaliplatinum preparation for parenteral administration and method for obtaining same
TWI236486B (en) * 2001-10-10 2005-07-21 Mitsui Chemicals Inc Crosslinkable aromatic resin having protonic acid group, and ion conductive polymer membrane, binder and fuel cell using the resin
US6476068B1 (en) 2001-12-06 2002-11-05 Pharmacia Italia, S.P.A. Platinum derivative pharmaceutical formulations
DE10314377A1 (de) * 2003-03-28 2004-10-07 Stada Arzneimittel Ag Gebrauchsfertige Oxaliplatin-Lösungen
JP2007504098A (ja) * 2003-08-28 2007-03-01 メイン・ファーマ・リミテッド 酸を含むオキサリプラチン製剤
CZ300795B6 (cs) * 2003-09-02 2009-08-12 Pliva-Lachema A. S. Farmaceutická kompozice a zpusob její výroby
WO2005051966A1 (en) 2003-11-25 2005-06-09 Platco Technologies (Proprietary) Limited Platinum(ii) complexes, preparation and use
ATE431828T1 (de) 2004-09-01 2009-06-15 Platco Technologies Proprietar Herstellung von platin(ii)-komplexen
DE102004052877B4 (de) 2004-11-02 2008-06-19 Ebewe Pharma Ges.M.B.H. Nfg.Kg Stabile wässrige Formulierungen eines Platin-Derivats
CN1311818C (zh) * 2004-11-22 2007-04-25 山东蓝金生物工程有限公司 一种抗实体肿瘤的药物组合物
JP2006248978A (ja) 2005-03-10 2006-09-21 Mebiopharm Co Ltd 新規なリポソーム製剤
WO2007029268A2 (en) * 2005-09-05 2007-03-15 Dabur Pharma Limited Stable oxaliplatin formulation
MX2008009774A (es) 2006-01-30 2008-10-17 Platco Technologies Proprietar Preparacion de complejos de platino (ii).
CZ300665B6 (cs) * 2007-01-22 2009-07-15 Pliva-Lachema A. S. Sterilní kapalná farmaceutická kompozice a zpusob její výroby
CZ300664B6 (cs) * 2007-01-22 2009-07-15 Pliva-Lachema A. S. Sterilní kapalná farmaceutická kompozice a zpusob její výroby
KR200449655Y1 (ko) * 2009-11-20 2010-07-28 김명환 보조손잡이캡이 부설된 밀폐형 접이식 우산
US8263578B2 (en) 2010-03-18 2012-09-11 Innopharma, Inc. Stable bortezomib formulations
AU2011227083B2 (en) 2010-03-18 2013-07-18 Innopharma, Inc. Stable bortezomib formulations
CN102670526B (zh) * 2012-05-10 2013-12-04 南京臣功制药股份有限公司 奥沙利铂冻干粉针剂及其制备方法
JP5314790B1 (ja) * 2012-07-09 2013-10-16 東和薬品株式会社 オキサリプラチン含有医薬組成物

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU5416394A (en) * 1992-11-24 1994-06-22 Debiopharm S.A. Cisplatinum/oxaliplatinum combination
US5455270A (en) * 1993-08-11 1995-10-03 Bristol-Myers Squibb Co. Stabilized solutions of platinum(II) antitumor agents
AU2989695A (en) * 1994-08-08 2000-03-07 Debiopharm S.A. Pharmaceutically stable oxaliplatinum preparation
ATE338553T1 (de) * 1997-03-07 2006-09-15 Sanofi Aventis Us Llc Antitumorkombination aus 3-amino-1,2,4- benzotriazine 1,4-dioxid/paclitaxel/platin
JP3774043B2 (ja) * 1997-09-12 2006-05-10 彰 辻 悪性腫瘍診断剤
GB9804013D0 (en) * 1998-02-25 1998-04-22 Sanofi Sa Formulations

Also Published As

Publication number Publication date
RU2252022C2 (ru) 2005-05-20
HK1048266A1 (en) 2003-03-28
ZA200200800B (en) 2003-06-25
JP4890711B2 (ja) 2012-03-07
ATE249825T1 (de) 2003-10-15
EP1207875A1 (fr) 2002-05-29
BRPI0013613B8 (pt) 2021-05-25
CA2382389A1 (fr) 2001-03-08
CA2382389C (fr) 2010-06-29
PT1207875E (pt) 2004-02-27
EP1207875B1 (fr) 2003-09-17
CN1371278A (zh) 2002-09-25
JP2003508436A (ja) 2003-03-04
KR100688217B1 (ko) 2007-02-28
DE60005376D1 (de) 2003-10-23
HK1048266B (zh) 2005-04-01
AU768169B2 (en) 2003-12-04
DE60005376T2 (de) 2004-07-01
AU6553000A (en) 2001-03-26
BR0013613B1 (pt) 2013-05-28
CZ298581B6 (cs) 2007-11-14
DK1207875T3 (da) 2004-01-19
WO2001015691A1 (fr) 2001-03-08
CN1170533C (zh) 2004-10-13
MXPA02002266A (es) 2003-08-20
UA71985C2 (uk) 2005-01-17
ES2206288T3 (es) 2004-05-16
KR20020033782A (ko) 2002-05-07
CZ2002291A3 (cs) 2002-10-16

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Legal Events

Date Code Title Description
B25G Requested change of headquarter approved

Owner name: DEBIOPHARM S.A. (CH)

Free format text: ALTERADA A SEDE DO TITULAR CONFORME REQUERIDO NA PETICAO NO 020040016032/RJ DE 10/12/2004.

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B15K Others concerning applications: alteration of classification

Free format text: ALTERADO DA INT. CL: A61K 31/282; A61K 33/24; A61K 9/08; A61K 31/55; A61K 47/10; A61K 47/22; A61K 47/26.

Ipc: A61K 31/282 (2009.01), A61K 33/24 (2009.01), A61K

B07B Technical examination (opinion): publication cancelled [chapter 7.2 patent gazette]

Free format text: REFERENTE A RPI 2005 DE 09/06/2009.

B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B09X Republication of the decision to grant [chapter 9.1.3 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 28/05/2013, OBSERVADAS AS CONDICOES LEGAIS.

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 30/08/2000 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF

B21A Patent or certificate of addition expired [chapter 21.1 patent gazette]

Free format text: PATENTE EXTINTA EM 30/08/2020