BG103540A - Производни на 6-фенилпиридил-2-амин полезни като nоs инхибитори - Google Patents

Производни на 6-фенилпиридил-2-амин полезни като nоs инхибитори Download PDF

Info

Publication number: BG103540A
Authority: BG; Bulgaria
Prior art keywords: phenyl; alkyl; disease; ylamine; pyridin
Prior art date: 1996-12-06

Application number

BG103540A

Other languages

Bulgarian (bg)

English (en)

Inventor

John Lowe

Original Assignee

Pfizer Inc.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-12-06

Filing date

1999-06-30

Publication date

2000-12-29

1999-06-30 Application filed by Pfizer Inc. filed Critical Pfizer Inc.

2000-12-29 Publication of BG103540A publication Critical patent/BG103540A/bg

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/73—Unsubstituted amino or imino radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
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- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
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- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Diabetes (AREA)
Pain & Pain Management (AREA)
Pulmonology (AREA)
Ophthalmology & Optometry (AREA)
Psychiatry (AREA)
Hematology (AREA)
Rheumatology (AREA)
Psychology (AREA)
Cardiology (AREA)
Addiction (AREA)
Heart & Thoracic Surgery (AREA)
Obesity (AREA)
Hospice & Palliative Care (AREA)
Endocrinology (AREA)
Emergency Medicine (AREA)
Immunology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Urology & Nephrology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyridine Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

BG103540A 1996-12-06 1999-06-30 Производни на 6-фенилпиридил-2-амин полезни като nоs инхибитори BG103540A (bg)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US3279396P	1996-12-06	1996-12-06
PCT/IB1997/001446 WO1998024766A1 (en)	1996-12-06	1997-11-17	6-phenylpyridyl-2-amine derivatives useful as nos inhibitors

Publications (1)

Publication Number	Publication Date
BG103540A true BG103540A (bg)	2000-12-29

Family

ID=21866837

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BG103540A BG103540A (bg)	1996-12-06	1999-06-30	Производни на 6-фенилпиридил-2-амин полезни като nоs инхибитори

Country Status (42)

Country	Link
US (3)	US6235750B1 (cs)
EP (1)	EP0946512B1 (cs)
JP (2)	JP3604399B2 (cs)
KR (1)	KR100360633B1 (cs)
CN (1)	CN1117077C (cs)
AP (1)	AP848A (cs)
AR (1)	AR010331A1 (cs)
AT (1)	ATE251612T1 (cs)
AU (2)	AU4791797A (cs)
BG (1)	BG103540A (cs)
BR (1)	BR9714381A (cs)
CA (1)	CA2273479C (cs)
CZ (1)	CZ293863B6 (cs)
DE (1)	DE69725465T2 (cs)
DK (1)	DK0946512T3 (cs)
DZ (1)	DZ2361A1 (cs)
EA (1)	EA002907B1 (cs)
ES (1)	ES2206691T3 (cs)
HN (2)	HN1997000027A (cs)
HR (1)	HRP970664A2 (cs)
HU (1)	HUP0001848A3 (cs)
ID (1)	ID19056A (cs)
IL (1)	IL130111A0 (cs)
IS (1)	IS5053A (cs)
MA (1)	MA26453A1 (cs)
NO (1)	NO313517B1 (cs)
NZ (1)	NZ335733A (cs)
OA (1)	OA11123A (cs)
PA (1)	PA8442201A1 (cs)
PE (1)	PE46499A1 (cs)
PL (1)	PL333918A1 (cs)
PT (1)	PT946512E (cs)
SI (1)	SI0946512T1 (cs)
SK (1)	SK70899A3 (cs)
TN (1)	TNSN97198A1 (cs)
TR (1)	TR199901259T2 (cs)
TW (1)	TW491840B (cs)
UA (1)	UA59379C2 (cs)
UY (1)	UY24799A1 (cs)
WO (1)	WO1998024766A1 (cs)
YU (1)	YU25399A (cs)
ZA (1)	ZA9710906B (cs)

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CN1546470A (zh) *	1996-03-29	2004-11-17	��ҩ��޹�˾	6-苯基吡啶-2-基胺衍生物及其药物组合物
US20010049379A1 (en)	1997-08-27	2001-12-06	Lowe John Adams	2-aminopyridines containing fused ring substituents
HN1998000118A (es) *	1997-08-27	1999-02-09	Pfizer Prod Inc	2 - aminopiridinas que contienen sustituyentes de anillos condensados.
HN1998000125A (es) *	1997-08-28	1999-02-09	Pfizer Prod Inc	2-aminopiridinas con sustituyentes alcoxi ramificados
FR2780971B1 (fr) *	1998-07-08	2001-09-28	Sod Conseils Rech Applic	Nouveaux derives de 2-aminopyridines, leur application en tant que medicaments et compositions pharmaceutiques les contenant
FR2791674A1 (fr) *	1999-04-02	2000-10-06	Sod Conseils Rech Applic	Nouveaux derives de 2-aminopyridines, leur utilisation en tant que medicaments et compositions pharmaceutiques les contenant
AR019190A1 (es) *	1998-07-08	2001-12-26	Sod Conseils Rech Applic	Derivados de 2-aminopiridinas, productos intermedios para su preparacion, medicamentos y composiciones farmaceuticas que los contienen y su uso para preparar medicamentos
TR200401803T2 (tr) *	1998-08-11	2004-11-22	Pfizer Products Inc.	NOS önleyicileri için yeni farmasötik kullanımlar.
US7115557B2 (en)	1998-09-25	2006-10-03	Sciaticon Ab	Use of certain drugs for treating nerve root injury
SE9803710L (sv)	1998-09-25	2000-03-26	A & Science Invest Ab	Användning av vissa substanser för behandling av nervrotsskador
CZ20013036A3 (cs)	1999-02-25	2002-03-13	Pfizer Products Inc.	2-aminopyridiny obsahující jako substituenty kondenzované kruhové skupiny
MXPA01013452A (es) *	1999-07-23	2002-07-02	Shionogi & Co	Inhibodores de diferenciacion th2.
FR2804429B1 (fr) *	2000-01-31	2003-05-09	Adir	Nouveaux derives de 4-sulfonamides piperidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
AU2002303264A1 (en) *	2001-04-09	2002-10-21	Bristol-Myers Squibb Company	Fused heterocyclic inhibitors of factor xa
US20030045449A1 (en) *	2001-08-15	2003-03-06	Pfizer, Inc.	Pharmaceutical combinations for the treatment of neurodegenerative diseases
CA2522323C (en) *	2003-04-14	2009-09-15	Pfizer Products Inc.	3-azabicyclo[3.2.1]octane derivatives as opioid receptor ligands
CN1295216C (zh) *	2003-07-04	2007-01-17	中国人民解放军军事医学科学院毒物药物研究所	吲哚酮类衍生物及其用于制备抗肿瘤药物的用途
CA2598484A1 (en) *	2005-02-21	2006-08-24	Proximagen Ltd.	Inhibition or treatment of dyskinesia
WO2006105795A1 (en) *	2005-04-08	2006-10-12	Leo Pharma A/S	Novel indolinone derivatives
US8633175B2 (en)	2006-08-09	2014-01-21	Glaxosmithkline Llc	Compounds as antagonists or inverse agonists at opioid receptors
CL2008001671A1 (es)	2007-06-08	2009-07-17	Janssen Pharmaceutica Nv	Compuestos derivados de piperidina/piperazina inhibidores de dgat1, composicion farmaceutica que los comprende; y su uso en el tratamiento de enfermedades metabolicas especialmente diabetes.
US8835437B2 (en)	2007-06-08	2014-09-16	Janssen Pharmaceutica N.V.	Piperidine/piperazine derivatives
JO2972B1 (en)	2007-06-08	2016-03-15	جانسين فارماسوتيكا ان. في	Piperidine / piperazine derivatives
WO2008148851A1 (en)	2007-06-08	2008-12-11	Janssen Pharmaceutica N.V.	Piperidine/piperazine derivatives
JP5579170B2 (ja)	2008-06-05	2014-08-27	ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ	Ｄｇａｔ阻害剤とｐｐａｒ作動薬を含有する薬剤組み合わせ物
UA105182C2 (ru)	2008-07-03	2014-04-25	Ньюрексон, Інк.	Бензоксазины, бензотиазины и родственные соединения, которые имеют ингибирующую nos активность
EP2404902A1 (en) *	2009-03-05	2012-01-11	Shionogi&Co., Ltd.	Piperidine and pyrrolidine derivatives having npy y5 receptor antagonism
US11013844B2 (en) *	2014-11-20	2021-05-25	City Of Hope	Treatment device for plasma virus inactivation
CN118384166A (zh)	2016-08-12	2024-07-26	阿西纳斯公司	用于调节激酶级联的联芳组合物和方法
BR112020005489A2 (pt)	2017-09-22	2020-09-24	Jubilant Epipad Llc,	composto da fórmula (i), composto de fórmula (ii), composto de fórmula (iii), processo de preparação de compostos de fórmula (i), processo de preparação de compostos de fórmula (ii), processo de preparação de compostos de fórmula (iii), composição farmacêutica, método para inibir uma ou mais famílias pad em uma célula, método para tratar uma afeção mediada por um ou mais pads, utilização do composto, método para o tratamento e/ou prevenção de uma afeção mediada por um ou mais distúrbios da família pad, método para o tratamento de artrite reumatoide e método de tratamento de câncer
SG11202003463XA (en)	2017-10-18	2020-05-28	Jubilant Epipad LLC	Imidazo-pyridine compounds as pad inhibitors
EP3707135A1 (en)	2017-11-06	2020-09-16	Jubilant Prodel LLC	Pyrimidine derivatives as inhibitors of pd1/pd-l1 activation
IL274762B2 (en)	2017-11-24	2023-10-01	Jubilant Episcribe Llc	Novel heterocyclic compounds as prmt5 inhibitors
CA3093527A1 (en)	2018-03-13	2019-09-19	Jubilant Prodel LLC	Bicyclic compounds as inhibitors of pd1/pd-l1 interaction/activation
US20220267269A1 (en) *	2019-06-14	2022-08-25	Srx Cardio, Llc	Compounds for the modulation of proprotein convertase subtilisin/kexin type 9 (pcsk9)
US12115154B2 (en) *	2020-12-16	2024-10-15	Srx Cardio, Llc	Compounds for the modulation of proprotein convertase subtilisin/kexin type 9 (PCSK9)

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WO1992014780A1 (en)	1991-02-19	1992-09-03	Akzo N.V.	Stabilized carbon monoxide-olefin copolymers
AU5704594A (en) *	1992-12-18	1994-07-19	Wellcome Foundation Limited, The	Pyrimidine, pyridine, pteridinone and indazole derivatives as enzyme inhibitors
US5621004A (en)	1994-06-03	1997-04-15	Robert W. Dunn	Method for treating emesis
WO1996018616A1 (en) *	1994-12-12	1996-06-20	Merck & Co., Inc.	Substituted 2-aminopyridines as inhibitors of nitric oxide synthase
CN1546470A (zh) *	1996-03-29	2004-11-17	��ҩ��޹�˾	6-苯基吡啶-2-基胺衍生物及其药物组合物
US6093743A (en)	1998-06-23	2000-07-25	Medinox Inc.	Therapeutic methods employing disulfide derivatives of dithiocarbamates and compositions useful therefor

1997
- 1997-02-18 HN HN1997000027A patent/HN1997000027A/es unknown
- 1997-11-17 AT AT97910587T patent/ATE251612T1/de not_active IP Right Cessation
- 1997-11-17 CN CN97180350A patent/CN1117077C/zh not_active Expired - Fee Related
- 1997-11-17 CA CA002273479A patent/CA2273479C/en not_active Expired - Fee Related
- 1997-11-17 PL PL97333918A patent/PL333918A1/xx unknown
- 1997-11-17 EP EP97910587A patent/EP0946512B1/en not_active Expired - Lifetime
- 1997-11-17 UA UA99063103A patent/UA59379C2/uk unknown
- 1997-11-17 DE DE69725465T patent/DE69725465T2/de not_active Expired - Fee Related
- 1997-11-17 WO PCT/IB1997/001446 patent/WO1998024766A1/en active IP Right Grant
- 1997-11-17 BR BR9714381-2A patent/BR9714381A/pt not_active Application Discontinuation
- 1997-11-17 ES ES97910587T patent/ES2206691T3/es not_active Expired - Lifetime
- 1997-11-17 CZ CZ19992017A patent/CZ293863B6/cs not_active IP Right Cessation
- 1997-11-17 PT PT97910587T patent/PT946512E/pt unknown
- 1997-11-17 HU HU0001848A patent/HUP0001848A3/hu unknown
- 1997-11-17 JP JP52539798A patent/JP3604399B2/ja not_active Expired - Fee Related
- 1997-11-17 TR TR1999/01259T patent/TR199901259T2/xx unknown
- 1997-11-17 SK SK708-99A patent/SK70899A3/sk unknown
- 1997-11-17 NZ NZ335733A patent/NZ335733A/xx unknown
- 1997-11-17 DK DK97910587T patent/DK0946512T3/da active
- 1997-11-17 IL IL13011197A patent/IL130111A0/xx unknown
- 1997-11-17 AU AU47917/97A patent/AU4791797A/en not_active Abandoned
- 1997-11-17 YU YU25399A patent/YU25399A/sh unknown
- 1997-11-17 EA EA199900448A patent/EA002907B1/ru not_active IP Right Cessation
- 1997-11-17 KR KR1019997004981A patent/KR100360633B1/ko not_active IP Right Cessation
- 1997-11-17 SI SI9730597T patent/SI0946512T1/xx unknown
- 1997-11-18 HN HN1997000149A patent/HN1997000149A/es unknown
- 1997-11-22 TW TW086117501A patent/TW491840B/zh active
- 1997-12-01 PE PE1997001080A patent/PE46499A1/es not_active Application Discontinuation
- 1997-12-03 DZ DZ970211A patent/DZ2361A1/xx active
- 1997-12-03 TN TNTNSN97198A patent/TNSN97198A1/fr unknown
- 1997-12-03 MA MA24884A patent/MA26453A1/fr unknown
- 1997-12-03 UY UY24799A patent/UY24799A1/es unknown
- 1997-12-04 ZA ZA9710906A patent/ZA9710906B/xx unknown
- 1997-12-04 PA PA19978442201A patent/PA8442201A1/es unknown
- 1997-12-04 AP APAP/P/1997/001156A patent/AP848A/en active
- 1997-12-04 HR HR60/032,793A patent/HRP970664A2/hr not_active Application Discontinuation
- 1997-12-04 AR ARP970105713A patent/AR010331A1/es not_active Application Discontinuation
- 1997-12-05 ID IDP973838A patent/ID19056A/id unknown
1999
- 1999-05-18 IS IS5053A patent/IS5053A/is unknown
- 1999-06-01 OA OA9900115A patent/OA11123A/en unknown
- 1999-06-03 US US09/325,480 patent/US6235750B1/en not_active Expired - Fee Related
- 1999-06-04 NO NO19992725A patent/NO313517B1/no unknown
- 1999-06-30 BG BG103540A patent/BG103540A/bg unknown
2001
- 2001-03-08 US US09/802,086 patent/US20020032191A1/en not_active Abandoned
- 2001-09-13 AU AU72050/01A patent/AU766080B2/en not_active Ceased
- 2001-09-27 US US09/965,564 patent/US20020103227A1/en not_active Abandoned
2004
- 2004-06-24 JP JP2004186311A patent/JP2005170924A/ja active Pending

Also Published As

Publication number	Publication date
CN1239952A (zh)	1999-12-29
TNSN97198A1 (fr)	2005-03-15
AP848A (en)	2000-06-09
PE46499A1 (es)	1999-05-12
IS5053A (is)	1999-05-18
HRP970664A2 (en)	1998-10-31
JP2000505814A (ja)	2000-05-16
DZ2361A1 (fr)	2002-12-28
HUP0001848A2 (hu)	2001-04-28
CZ293863B6 (cs)	2004-08-18
CZ201799A3 (cs)	2000-07-12
ES2206691T3 (es)	2004-05-16
ID19056A (id)	1998-06-11
HUP0001848A3 (en)	2002-03-28
CN1117077C (zh)	2003-08-06
PA8442201A1 (es)	2000-05-24
ATE251612T1 (de)	2003-10-15
US6235750B1 (en)	2001-05-22
US20020103227A1 (en)	2002-08-01
IL130111A0 (en)	2000-06-01
CA2273479A1 (en)	1998-06-11
EA199900448A1 (ru)	2000-02-28
MA26453A1 (fr)	2004-12-20
NO992725L (no)	1999-06-04
DK0946512T3 (da)	2004-01-12
DE69725465D1 (de)	2003-11-13
UY24799A1 (es)	2001-08-27
YU25399A (sh)	2001-07-10
CA2273479C (en)	2006-02-07
AU7205001A (en)	2001-11-15
ZA9710906B (en)	1999-06-09
PL333918A1 (en)	2000-01-31
TW491840B (en)	2002-06-21
BR9714381A (pt)	2000-05-02
NO992725D0 (no)	1999-06-04
US20020032191A1 (en)	2002-03-14
JP3604399B2 (ja)	2004-12-22
AR010331A1 (es)	2000-06-07
NZ335733A (en)	2001-01-26
KR100360633B1 (ko)	2002-11-13
HN1997000027A (es)	1997-06-05
EP0946512B1 (en)	2003-10-08
HN1997000149A (es)	1997-12-26
PT946512E (pt)	2004-01-30
EA002907B1 (ru)	2002-10-31
JP2005170924A (ja)	2005-06-30
UA59379C2 (uk)	2003-09-15
DE69725465T2 (de)	2004-05-06
SI0946512T1 (en)	2004-04-30
AP9701156A0 (en)	1998-01-31
KR20000057413A (ko)	2000-09-15
WO1998024766A1 (en)	1998-06-11
NO313517B1 (no)	2002-10-14
OA11123A (en)	2003-04-07
TR199901259T2 (xx)	1999-08-23
EP0946512A1 (en)	1999-10-06
SK70899A3 (en)	2002-04-04
AU766080B2 (en)	2003-10-09
AU4791797A (en)	1998-06-29

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