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AU5337499A - Low adenosine anti-sense oligonucleotide agent, composition, kit and treatments - Google Patents

Low adenosine anti-sense oligonucleotide agent, composition, kit and treatments Download PDF

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AU5337499A
AU5337499A AU53374/99A AU5337499A AU5337499A AU 5337499 A AU5337499 A AU 5337499A AU 53374/99 A AU53374/99 A AU 53374/99A AU 5337499 A AU5337499 A AU 5337499A AU 5337499 A AU5337499 A AU 5337499A
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Jonathan W. Nyce
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East Carolina University
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    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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Description

WO 00/09525 PCT/US99/17712 EPI-109 LOW ADENOSINE ANTI-SENSE OLIGONUCLEOTIDE AGENT, COMPOSITION, KIT & TREATMENTS BACKGROUND OF THE INVENTION Field of the Invention This application relates to an agent comprising anti-sense oligonucleotides of low or no adenosine content. These agents are suitable for the treatment of diseases associated with inflamfation, impaired airways, including lung disease and diseases whose secondary effects afflict the lungs of a subject. Examples of these diseases are allergies, asthma, impeded respiration, pain, cystic fibrosis, and- cancers such as leukemias, e.g. colon cancer, and the like. The present agent may be administered prophylactically or therapeutically in conjunction with other therapies, or may be utilized as a substitute for therapies that have significant, negative side effects. Background of the Invention Respiratory ailments, associated with a variety of diseases and conditions, are extremely common in the general population, and more so in certain ethnic groups, such as African Americans. In some cases they are accompanied by inflammation, which aggravates the condition of the lungs. Asthma, for example, is one of the most common diseases in industrialized countries. In the United States it accounts for about 1 % of all health care costs. An alarming increase in both the prevalence and mortality of asthma over the past decade has been reported, and asthma is predicted to be the preeminent occupational lung disease in the next decade. While the increasing mortality of asthma in industrialized countries could be attributable to the increased reliance upon beta agonists in the treatment of this disease, the underlying causes of asthma remain poorly understood. Anti-sense oligonucleotides have received considerable theoretical consideration as potential useful pharmacological agents in human disease. Their practical application in actual models of human disease, however, has been somewhat elusive. One important impediment to their effective application has been a difficulty in finding an appropriate route of administration to deliver them to their site of action. Many in vivo experiments were conducted by administering anti-sense oligonucleotides directly to specific regions of the brain. These applications, however, necessarily have limited clinical utility due to their invasive nature. The systemic administration of anti-sense oligonucleotides also presents significant problems, not the least being an inherent difficulty in targeting disease-involved tissues. In contrast, the lung is an excellent target for the direct administration of anti-sense oligonucleotides, and provides a non-invasive and a tissue-specific route. The delivery of anti-sense agents to the lung has been relatively undeveloped. Adenosine may constitute an important mediator in the lung for various diseases, including bronchial asthma. Its potential role was suggested by the finding that asthmatics respond favorably to aerosolized adenosine with marked bronchoconstriction whereas normal individuals do not. An asthmatic rabbit animal model, the dust mite allergic rabbit model for human asthma, responded in a similar fashion to aerosolized adenosine with marked bronchoconstriction whereas non-asthmatic rabbits showed no response. More recent work with this animal model suggested that adenosine-induced bronchoconstriction and bronchial hyperresponsiveness in asthma may be mediated primarily through the stimulation of adenosine receptors. Adenosine has also been shown to cause adverse effects, including death, when administered therapeutically for other diseases and conditions in subjects with previously undiagnosed hyper reactive airways. A handful of medicaments have been available for the treatment of respiratory diseases and conditions, although in general they all have limitations. Theophylline, an important drug in the treatment of asthma, is a known adenosine receptor antagonist which was reported to eliminate adenosine-mediated bronchoconstriction in asthmatic rabbits. A selective adenosine A, receptor antagonist, 8-cyclopentyl-1, 3-dipropylxanthine (DPCPX) was also reported to inhibit adenosine-mediated bronchoconstriction and bronchial hyperresponsiveness in allergic rabbits. The therapeutic and preventative applications of currently available adenosine A, receptor-specific antagonists are, nevertheless, limited by their toxicity. Theophylline, for example, has been widely used in the treatment of asthma, but is associated with frequent, significant toxicity resulting from its narrow therapeutic dose range. DPCPX is far too toxic to be useful clinically. The fact that, despite decades of extensive research, no specific adenosine receptor antagonist is available for clinical use attests to the general toxicity of these agents. Anti-sense oligonucleotides have received considerable theoretical consideration for their potential use as WO 00/09525 PCTIUS99/17712 2 pharmacological agents in human disease. Finding practical and effective applications of these agents in actual models of human disease, however, have been few and far between, particularly because they had to be administered in large doses. Another important consideration in the pharmacologic application of these molecules is their route of administration. Many in vivo applications have involved the direct administration of anti-sense oligonucleotides to limited regions of the brain. Such applications, however, have limited clinical utility due to their invasive nature. The systemic administration of anti-sense oligonucleotides as pharmacological agents has been found to have also significant problems, not the least of which being a difficulty in targeting disease-involved tissues. That is, the necessary dilution of the anti-sense oligonucleotide in the circulatory system makes extremely difficult to attain a therapeutic dose at the target tissue by intravenous or oral administration. The bioavailability of orally administered anti-sense oligonucleotides is very low, of the order of less than about 5%. There are presently no effective therapies for treating these ailments, or at least no therapies which are effective and devoid of significant detrimental side effects. Accordingly, there is still a need for an agent for the treatment of ailments afflicting the lung airways, including respiratory problems and inflammation, which is highly effective and producing minimal, or entirely devoid of, side effects. SUMMARY OF THE INVENTION This invention relates to an agent which comprises an oligonucleotide (oligo) consisting essentially of less than about 15% adenosine (A), which is selected from the group consisting of anti-sense oligonucleotides to mRNAs corresponding to target genes, to genomic flanking regions selected from the group consisting of intron and exon borders, such as the 5' end, the 3' end and the juxta-section between coding and non-coding regions, and to all segments of mRNAs encoding polypeptides associated with ailments afflicting lung airways, combinations thereof, pharmaceutically acceptable salts thereof, and mixtures thereof. The mRNA(s), for example, encode polypeptide(s) such as transcription factors, stimulating and activating factors, interleukins, interleukin receptors, chemokines, chemokine receptors, endogenously produced specific and non-specific enzymes, immunoglobulins, antibody receptors, central nervous system (CNS) and peripheral nervous and non nervous system receptors, CNS and peripheral nervous and non-nervous system peptide transmitters, adhesion molecules, defensines, growth factors, vasoactive peptides and receptors, and binding proteins; or those mRNA which correspond to an oncogene. The agents is are provided in the form of specific compositions and formulations, with a carrier, and optionally with other therapeutic agents and additives which are typically used for administration by a specific route, e.g. into the respiratory system. The agent is also provided as a capsule or cartridge, and in the form of a kit. This agent is suitable for the treatment of diseases and conditions associated with impaired respiration and inflammation, including lung diseases, ailments and conditions that have a negative effect on the lungs of a subject. Examples of diseases and conditions, which may be treated preventively, prophylactically and therapeutically with the agent of this invention, are pulmonary vasoconstriction, inflammation, allergies, asthma, impeded respiration, respiratory distress syndrome, pain, cystic fibrosis, pulmonary hypertension, pulmonary vasoconstriction, emphysema, chronic obstructive pulmonary disease (COPD), and cancers such as leukemias, lymphomas, carcinomas, and the like, e.g. colon cancer, breast cancer, lung cancer, pancreatic cancer, hepatocellular carcinoma, kidney cancer, melanoma, hepatic metastases, etc., as well as all types of cancers which may metastasize or have metastasized to the lung(s), including breast and prostate cancer. The present agent(s) is (are) also suitable for administration before, during and after other treatments, including radiation, chemotherapy, antibody therapy, phototherapy and cancer, and other types of surgery. Alternatively, the present agent may be effectively administered preventively, prophylactically or therapeutically, and in conjunction with other therapies, or by itself for conditions without known therapies or as a substitute for therapies that have significant negative side effects. The composition of this invention may be administered by transdermal or systemic routes, including by, but not exclusively, oral, intracavitary, intranasal, intraanal, intravaginal, transdermal, intradermal, intrabuccal, intravenous, subcutaneous, intramuscular, intratumor, intraglandular, by inhalation, intraarterial, intravascular in general, into the ear, intracranial, intrathecal, intraorgan including via a shunt to, for example, the liver or other organs, by implantation and intraocular administration to a human or any other animal, including vertebrates, such as mammals. In a preferred embodiment, the present agents are administered directly into the respiratory WO 00/09525 PCT/US99/17712 3 system of a subject, so that the agent has direct access to the lungs, in an amount effective to reduce or inhibit the effect in the lung of the targeted diseases or conditions. Also part of this invention is a method of producing an anti-sense oligonucleotide consisting essentially of less than about 15% adenosine (A), by selecting a target including genes, genomic flanking regions, RNAs and polypeptide associated with an ailment afflicting the lung airways, obtaining the sequence of a mRNA(s) corresponding to the target gene(s) and/or their genomic flanking region(s) and/or the juxta-membrane regions thereof, and mRNA(s) encoding the target polypeptide(s), selecting at least one segment of the mRNA(s), and synthesizing one or more anti-sense oligonucleotide(s) to the selected mRNA segment(s), and substituting, if necessary, a universal base(s) for one or more A to reduce the proportion of A present in the oligonucleotide to less than 15%. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS This invention arose from a desire by the inventor to improve on his own prior discovery that anti-sense oligonucleotides (oligos) may be utilized therapeutically in the treatment of diseases or conditions which impair respiration, cause inflammation, constrict bronchial tissue or the lung airways, or otherwise impede normal breathing. The inventor reasoned that he could improve on his prior discovery that anti-sense oligos targeted to genes associated with such ailments could effectively treat and prevent the effects and symptomatology of such disease(s) or condition(s). The present invention is premised on the recent discovery by the inventor that oligonucleotides are metabolized in vivo to their deoxynucleotides. In the case of adenosine (A)-containing oligonucleotides, there is break down with release of deoxyadenosine which, in turn, activates adenosine receptors causing bronchoconstriction, inflammation and the like. The present technology relies on the design of anti-sense oligos targeted to mRNAs associated with ailments involving lung airway pathology(ies), and on their modification to reduce the occurrence of undesirable side effects caused by their release of adenosine upon breakdown, while preserving their activity and efficacy for their intended purpose. In this manner, the inventor targets a specific gene to design one or more anti-sense oligonucleotide(s) (oligos) that selectively bind(s) to the corresponding mRNA, and then reduces, if necessary, their content of adenosine via substitution with universal base or an adenosine analog incapable of activating adenosine A, A2b or A 3 receptors. Based on his prior experience in the field, the inventor reasoned that in addition to Adownregulating@ specific genes, he could increase the effect of the agent(s) administered by either selecting segments of RNA that are devoid, or have a low content, of thymidine (T) or, alternatively, substitute one or more adenosine(s) present in the designed oligonucleotide(s) with other nucleotide bases, so called universal bases, which bind to thymidine but lack the ability to activate adenosine receptors and otherwise exercise the constricting effect of adenosine in the lungs, etc. Given that adenosine (A) is a nucleotide base complementary to thymidine (T), when a T appears in the RNA, the anti-sense oligo will have an A at the same position. For consistency's sake, all RNAs and oligonucleotides are represented in this patent by a single strand in the 5' to 3' direction, when read from left to right, although their complementary sequence(s) is (are) also encompassed within the four corners of the invention. In addition, all nucleotide bases and amino acids are represented utilizing the recommendations of the IUPAC-IUB Biochemical Nomenclature Commission, or by the known 3-letter code (for amino acids). The method of the present invention may be used to treat ailments associated with reduced airway function in a subject, whatever its cause. The adenosine content of the anti-sense agent(s) of the invention have a reduced A content to prevent its liberation upon in vivo degradation of the agent(s). Examples of airway diseases that may be treated by the method of the present invention include cystic fibrosis, asthma, pulmonary hypertension and vasoconstriction, chronic obstructive pulmonary disease (COPD), chronic bronchitis, respiratory distress syndrome, lung cancer and lung metastatic cancers and other airway diseases, including those with inflammatory response. Anti-sense oligos to the adenosine A 1 , A2a, A2b, and A 3 receptors, CCR3 (chemokine receptors), bradykinin 2B, CAM (vascular cell adhesion molecule), and eosinophil receptors, among others, have been shown to be effective in down-regulating the expression of their genes. Some of these act to alleviate the symptoms or reduce respiratory ailments and/or inflammation, for example, by Adown regulation@ of the adenosine A 1 , A2a, A2b, and/or A 3 receptors and CCR3, bradykinin 2B, VCAM (vascular cell adhesion molecule) and eosinophil receptors. These agents are preferably administered directly into the respiratory system, e.g., by WO 00/09525 PCT/US99/17712 EPI-109 4 inhalation or other means, so that they may reach the lungs without widespread systemic dissemination. This permits the use of substantially lower doses of the agent of the invention as compared with those administered by the prior art, systemically or by other generalized routes and, consequently, reduce undesirable side effects resulting from the agent's widespread distribution in the body. The agent(s) of this invention has (have) been shown to reduce the amount of receptor protein expressed by the tissue. These agents, thus, rather than merely interacting with their targets, e.g. a receptor, lower the number of target proteins that other drugs may interact with. In this manner, the present agent(s) afford(s) extremely high efficacy with low toxicity. The adenosine receptors discussed above are mere examples of the high power of the inventor's technology. In fact, a large number of genes may be targeted in a similar manner by the present agent(s), to reduce or down-regulate protein expression. By means of example, if the target disease or condition is one associated with impeded or reduced breathing, bronchoconstriction, chronic bronchitis, pulmonary bronchoconstriction and/or hypertension, chronic obstructive pulmonary disease (COPD), allergy, asthma, cystic fibrosis, respiratory distress syndrome, cancers, which either directly or by metastasis afflict the lung, the present method may be applied to a list of potential target mRNAs, which includes the targets listed in Table 1 below, among others. Table 1: Pulmonary Disease or Condition (Asthma/Inflammation) Targets Nf6B Transcription Factor lnterleukin-8 Receptor (IL-8R) Interleukin-5 Receptor (IL-5R) lnterleukin-4 Receptor (IL-4R) Interleukin-3 Receptor (IL-3R) Interleukin-1beta (IL-Ibeta) Interleukin- 1P Receptor (IL- Ibeta R) Eotaxin Tryptase Major Basic Protein p2-adrenergic Receptor Kinase Endothelin Receptor A Endothelin Receptor B Preproendothelin Bradykinin B2 Receptor (B2BR) IgE (High Affinity Receptor) Interleukin-1 (IL-1) Interleukin I Receptor (IL-i R) Interleukin-9 (IL-9) Interleukin-9 Receptor (IL-9 R) Interleukin- 11 (IL-11) Interleukin- II Receptor (IL-li R) Inducible Nitric Oxide Synthase Cyclooxygenase (COX) Intracellular Adhesion Molecule 1 (ICAM-1) Vascular Cellular Adhesion Molecule (VCAM) Rantes Endothelial Leukocyte Adhesion Molecule (ELAM-1) Cyclooxygenase-2 (COX-2) GM-CSF, Endothelin-1 Monocyte Activating Factor Neutrophil Chemotactic Factor Neutrophil Elastase Defensin 1,2,3 Muscarinic Acetylcholine Receptors Platelet Activating Factor Tumor Necrosis Factor a 5-lipoxygenase Phosphodiesterase IV Substance P Substance P Receptor Histamine Receptor Chymase CCR-1 CC Chemokine Receptor Interleukin-2 (IL-2) Interleukin-4 (IL-4) Interleukin-12 (IL-12) Interleukin-5 (IL-5) Interleukin-6 (IL-6) Interleukin-7 (IL-7) Interleukin-8 (IL-8) Interleukin-12 Receptor (IL-i2R) Interleukin-7 Receptor (IL-7R) Interleukin-1 (IL-1) Interleukin-14 Receptor (IL-14R) Interleukin- 14 CCR-2 CC Chemokine Receptor CCR-3 CC Chemokine Receptor CCR-4 CC Chemokine Receptor CCR-5 CC Chemokine Receptor Prostanoid Receptors GATA-3 Transcription Factor Neutrophil Adherence Receptor MAP Kinase Interleukin-15 (IL-15) Interleukin-15 Receptor (IL-i5R) Interleukin-11 (IL-11) Interleukin-II Receptor (IL- 1R) NFAT Transcription Factors STAT 4 MIP-la MCP-2 MCP-3 MCP-4 Cyclophillin (A, B, etc.) Phospholipase A2 Basic Fibroblast Growth Factor Metalloprotetase WO 00/09525 PCT/US99/17712 EPI-109 5 CSBP/p38 MAP Kinase Tryptase Receptor PDG2 Interleukin-3 (IL-3) Interleukin-10 (IL-10) Cyclosporin A - Binding Protein FK506-Binding Protein a4pl Selectin Fibronectin a4P7 Selectin cMad CAM-1 LFA-1 (CD1 la/CD18) PECAM-1 LFA-1 Selectin C3bi PSGL-1 E-Selectin P-Selectin CD-34 L-Selectin p150,95 Mac-i (CD1lb/CD18) Fucosyl transferase VLA-4 CD-18/CD11a CDI1b/CD18 ICAM2 and ICAM3 C5a CCR3 (Eotaxin Receptor) CCR1, CCR2, CCR4, CCR5 LTB-4 AP-1 Transcription Factor Protein kinase C Cysteinyl Leukotriene Receptor Tachykinnen Receptors (tach R) 1KB Kinase 1 & 2 Interleukin-2 Receptor (IL-2R) (e.g., Substance P, NK-i & NK-3 Receptors) STAT 6 c-mas NF-Interleukin-6 (NF-IL-6) interleukin-10 Receptor (IL-i R) Interleukin-3 (IL-3) Interleukin-2 Receptor (IL-2R) Interleukin- 13 (IL-13) Interleukin- 12 Receptor (IL- 2R) Interleukin-14 (IL-14) Interieukin-6 Receptor (IL-6R) Interleukin-16 (IL-16) Interleukin-13 Receptor (IL-13R) Medullasin Interleukin-16 Receptor (IL-i6R) Adenosine A, Receptor (A, R) Tryptase-I Adenosine A,, Receptor (A2b R) Adenosine A 3 Receptor (A 3 R) p Tryptase Adenosine A, Receptor (A2. R) IgE Receptor 0 Subunit (IgE R P) Fc-epsilon receptor CD23 antigen IgE Receptor a Subunit (IgE R a) IgE Receptor Fc Epsilon Receptor (IgERFc R) Substance P Receptor Histidine decarboxylase Tryptase- 1 Prostaglandin D Synthase Eosinophil Cationic Protein Eosinophil Derived Neurotoxin Eosinophil Peroxidase Endothelial Nitric Oxide Synthase Endothelial Monocyte Activating Factor Neutrophil Oxidase Factor Cathepsin G Macrophage Inflammatory Protein-i- Interleukin-8 Receptor a Subunit (IL-8 R a) Alpha/Rantes Receptor Substance P Endothelin Receptor ET-B Endothelin ETA Receptor Examples of other targets are 5-lipoxygenase, a-Rantes receptor, Cathepsin G, CCR-1 CC Chemokine receptor, CCR-i CC Chemok(e receptor, CCCR-5 CC Chemokine receptor,, CD-s) -CD1a, c-Mas, Endothelial Nitric Oxide Synthase, Endothelial receptor ET-B, Endothelin 1, Eosinophil Cationic Proetin, Eosinophil Derived Neurotoxin, Fc-e receptor (CD 23 Antigen), Histidine Decarboxylase, Interleukin 10 (IL 10), IL-10 receptor, IL-i1 receptor, IL-i2, IL-i2 receptor, IL-13, IL-13 receptor, IL-14 and its receptor, IL-i and its receptor, IL-16 and its receptor, IL-6 and its receptor, IL-7 and its receptor, Intracellular Adhesion Molecule -2 (ICAM-2), ICAM-3, Meduliasin, Neurokinin-3 receptor (NK-3 R), Neutrophil Oxidase Factor, Platelet Activating Factor receptor, Prostag(andin D Synthase, Protein Kinase c, P-Selectin Glycoprotein Ligand T (PSGL-1), Tryptase Activated receptor, IL-2 and its receptor, IL-3 and its receptor, IL-4 and its receptor, IL and its receptor, IL-8 and its receptor, IL-9 and its receptor, Intracellular adhesion Molecule-i, Leukocyte Adhesion Glycoprotein, Leukotriene C-4 Synthase, Major Basic Protein, MCP-3, Monocyte Asctuating Factor, Muscarinic Acetylcholine receptors, Neurokinin- Receptor, Neutrophil Chemotactic Factor, Neutrophil Elastase, NfKB, Phosphodiesterase IV. Prostaglandin Receptor, P-selectin, Rantes, Stat-i, Stat-2, Stat-3, Substance P and its receptor, Tryptase, Tumor Necrosis Factor A, Vascular Cellular Adhesion Molecule, AP- Transcription Factor, Basic Fibroblast Growth Factor, C5a, CCR-2 CC Chemokine Receptor, CSBP-p38 MAP Kinase, WO 00/09525 PCT/US99/17712 EPI-109 6 Cyclooxygenase-2 (COX-2), Cyclophilin (A, B, C, and the rest), Cyclosporin A Binding Protein, Cysteinyl Leukotriene Receptor, E-Selectin, Fibronectin, Fusosyl Transferase, GATAS-3 Transcription Factor, Granulocyte-Macrophage Stimulating Factor (GM-CSF), Histamine Receptor, IKB Kinase 1 and 2, nterleukin 7, L-Selectin, Mac-i (CD11b and CD18), Mad CAM-1, Map Kinase, MCP-4, Metalloproteinase, MIP-la, Neutrophil Adherence Receptors, NFAT Transcription Factors, NF-Interleukin-6 (NF-IL-6), Pecam 1,Phospholipase A2, Prostanoid Receptors, Stat-4, Stat-6, VLA-4, and others. The oligos of this invention may be obtained by first selecting fragments of a target nucleic acid having at least 4 contiguous nucleic acids selected from the group consisting of G and C, and then obtaining a first oligonucleotide 4 to 60 nucleotides long which comprises the selected fragment and has a C and G nucleic acid content of up to and including about 15%. The latter step may be conducted by obtaining a second oligonucleotide 4 to 60 nucleotides long comprising a sequence which is anti-sense to the selected fragment, the second oligonucleotide having an adenosine base content of up to and including about 15%. This method may also comprise, when the selected fragment comprises at least one thymidine base, substituting an adenosine base in the corresponding nucleotide of the anti-sense fragment with a universal base selected from the group consisting of heteroaromatic bases which bind to a thymidine base but have antagonist activity and less than about 0.3 of the adenosine base agonist activity at the adenosine A,, A2b and A, receptors, and heteroaromatic bases which have no activity or have an agonist activity at the adenosine A2. receptor. The analogue heteroaromatic bases may be selected from all pyrimidines and purines, which may be substituted by 0, halo, NH 2 , SH, SO, SO2, SO 3 , COOH and branched and fused primary and secondary amino, alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, alkoxy, alkenoxy, acyl, cycloacyl, arylacyl, alkynoxy, cycloalkoxy, aroyl, arylthio, arylsulfoxyl, halocycloalkyl, alkylcycloalkyl, alkenylcycloalkyl, alkynylcycloalkyl, haloaryl, alkylaryl, alkenylaryl, alkynylaryl, arylalkyl, arylalkenyl, arylalkynyl, arylcycloalkyl, which may be further substituted by 0, halo,
NH
2 , primary, secondary and tertiary amine, SH, SO, SO 2 , SO3, cycloalkyl, heterocycloalkyl and heteroaryl. The pyrimidines and purines may be substituted at all positions as is known in the art, but preferred are those which are substituted at positions 1, 2, 3, 4, 7 and/or 8. More preferred are pyrimidines and purines such as theophylline, caffeine, dyphylline, etophylline, acephylline piperazine, bamifylline, enprofylline and xantine having the chemical formula 0 M I I I S C N 0 C wherein R 1 and R 2 are independently H, alkyl, alkenyl or alkynyl and R 3 is H, aryl, dicycloalkyl, dicycloalkenyl, dicycloalkynyl, cycloalkyl, cycloalkenyl, cycloalkynyl, 0-cycloalkyl, 0-cycloalkenyl, 0-cycloalkynyl, NH 2 alkylamino-ketoxyalkyloxy-aryl, mono and dialkylaminoalkyl-N-alkylamino-SO 2 aryl, among others. The inventor reduced the adenosine content of the anti-sense oligos corresponding to the thymidines (T) present in the target RNA to less than about 15%, or fully eliminated A from the oligonucleotide sequence as a means for preventing their breakdown products from freeing adenosine into the lung tissue environment and, thereby, aggravating the subject's ailment and/or countering the beneficial effect of the administered agent. By means of example, the Nf6B transcription factor may be selected as a target, and its mRNA or DNA searched for low thymidine (T) or desthymidine (desT) fragments. Only desT segments of the mRNA or DNA are selected which, in turn, will produce desA anti-sense as their complementary strand. When a number of RNA desT segments are found, the sequence of the anti-sense segments may be deduced. Typically, about 10 to 30 and even larger numbers of desA anti-sense sequences may be obtained. These anti-sense sequences may include some or all desA anti-sense oligonucleotide sequences corresponding to desT segments of the mRNA of the target, such as anyone of those shown in Table 1 above or Table 2 below. When this occurs, the anti-sense oligonucleotides found are said to be 100% A-free. For each of the original desA anti-sense oligonucleotide sequences corresponding to the target gene, e.g. the NF6B transcription factor, typically about 10 to 30 sequences WO 00/09525 PCT/US99/17712 EPI-109 7 may be found within the target gene or RNA which have a low content of thymidine (RNA). In accordance with this invention, the selected fragment sequences may also contain a small number of thymidine (RNA) nucleotides within the secondary or tertiary or quaternary sequences. In some cases, a large adenosine content may suffice to render the anti-sense oligonucleotide less active or even inactive against the target. In accordance with this invention, these so called A non-fully desA sequences may preferably have a content of adenosine of less than about 15%, more preferably less than about 10%, and still more preferably less than 5%, and some even less than 2% adenosine. In some instances a higher content of adenosine is acceptable and the oligonucleotides are still active, particularly where the adenosine nucleotide may be Afixed@ or replaced with a AUniversal@ base that may base-pair with similar or equal affinity to two or more of the four nucleotide present in natural DNA: A, G, C, and T. A universal base is defined in this patent as any compound, more commonly an adenosine analogue, having the capacity to hybridize to thymidine, preferably having substantially reduced, or substantially lacking, ability to bind adenosine receptors. Alternatively, adenosine analogs which do not activate adenosine receptors, such as the adenosine A 1 , A 2 and/or A, receptors, most preferably A, receptors, may be used. One example of a universal base is a-deoxyribofuranosol-(5-nitroindole), and an artisan will know how to select others. This Afixing@ step generates a further novel sequence, different from the one found in nature, that permits the anti sense oligonucleotide to bind, preferably equally well, with the target RNA. An example of a universal base is 2 deoxyribosyl-(5-nitroindole). Other examples of universal bases are 3-nitropyrrole-2'-deoxynucleoside, 5-nitro indole, 2-deoxyribosyl-(5-nitroindole), 2-deoxyribofuranosyl-(5-nitroindole), 2'-deoxyinosine, 2' deoxynebularine, 6H, 8H-3,4-dihydropyrimido [4,5-c] oxazine-7-one and 2-amino-6-methoxyaminopurine. In addition to the above, Universal bases which may be substituted for any other base although with somewhat reduced hybridization potential, include 3-nitropyrrole 2'-deoxynucleoside 2-deoxyribofuranosyl-(5-nitroindole), 2'-deoxyinosine and 2'-deoxynebularine (Glen Research, Sterling, VA). More specific mismatch repairs may be made using "P' nucleotide, 6H, 8H-3, 4-dihydropyrimido[4,5-c] [1,2] oxazin-7-one, which base pairs with either guanine (G) or adenine (A) and "K" nucleotide, 2-amino-6-methoxyaminopurine, which base pairs with either cytidine (C) or thymidine (T), among others. Others which are known in the art are also suitable. See, for example, Loakes, D. and Brown, D. M., Nucl .Acids Res. 22:4039-4043 (1994); Ohtsuka, E. et al., J. Biol. Chem.260(5):2605-2608 (1985); Lin, P.K.T. and Brown, D. M., Nucleic Acids Res. 20(19):5149-5152 (1992; Nichols, R. et al., Nature 369(6480): 492-493 (1994); Rahmon , M. S. and Humayun, N. Z., Mutation Research 377 (2): 263-8 (1997); Amosova, 0., et al., Nucleic Acids Res. 25 (!0): 1930-1934 (1997); Loakes D. & Brown, D. M., Nucleic Acids Res. 22 (20): 4039-4043 (1994), the entire sections relating to universal bases and their preparation and use in nucleic acid binding is inceorporated herein by reference. When non-fully desT sequences are found in the naturally occurring target, they typically are selected so that about 1 to 3 universal base substitutions will suffice to obtain a 100% AdesA@ anti-sense oligonucleotide. Thus, the present method provides either anti-sense oligonucleotides to different targets which are low in, or devoid of, A content, as well as anti-sense oligonucleotides where one or more adenosine nucleotides, e. g. about 1 to 3, or more, may be Afixed@ by replacement with a AUniversal@ base. Universal bases are known in the art and need not be listed herein. An artisan will know which bases may act as universal bases, and replace them for A. The present approach to the design of anti-sense oligonucleotide approach is also applicable to a variety of other diseases or conditions, including other inflammatory diseases, such as cystic fibrosis, chronic obstructive pulmonary disease, chronic bronchitis, pulmonary hypertension, cancers, including those which metastasize to the lung, such as breast cancer, colon cancer, respiratory distress syndrome, prostate cancer, pancreatic cancer, kidney cancer, lymphomas, melanomas, hepatocellular carcinomas, etc. As used herein, the term "treat" or "treating" asthma or other respiratory and inflammatory conditions or diseases refers to a treatment which decreases the likelihood that the subject administered such treatment will manifest symptoms of a respiratory or inflammatory lung disease or other lung conditions. The term "down regulate" refers to inducing a decrease in production, secretion or availability (and thus a decrease in concentration) of the targeted intracellular protein. The present invention is concerned primarily with the treatment of vertebrates, and within this group, of mammals, including human and non-human simians, wild and domesticated animals, marine and land animals, household pets, and zoo animals, for example, felines, canines, equines, pachiderms, cetaceans, and still more preferably to human subjects. One particularly suitable application of this technology is for veterinary purposes, WO 00/09525 PCT/US99/17712 EPI-109 8 and includes all types of small and large animals in the care of a veterinarian, including wild animals, marine animals, household animals, zoo animals, and the like. Targeted genes and proteins are preferably mammalian, and the sequences targeted are preferably of the same species as the subject being treated. Although in many instances, targets of a different species are also suitable, particularly those segments of the target RNA or gene that display greater than about 45% homology, preferably greater than about 85% homology, still more preferably greater than about 95% homology, with the recipient's sequence. A preferable group of agents is composed of des-A anti-sense oligos. Another preferred group is composed of non-fully desA oligonucleotides, where one or more adenosine bases are replaced with universal bases. The terms "anti-sense" oligonucleotides generally refers to small, synthetic oligonucleotides, resembling single-stranded DNA, which in this patent are applied to the inhibition of gene expression by inhibition of a target messenger RNA (mRNA). See, Milligan, J. F. et al., J. Med. Chem. 36(14), 1923-1937 (1993), the relevant portion of which is hereby incorporated in its entirety by reference. The present agents inhibit gene expression of target genes, such as those of the adenosine A, A2a, A 2 b, or A, receptors, CCR3 (chemical receptor 320, also known as the eotaxin receptor), VCAM (vascular cell adhesion molecule), eonophil receptor, bradykinin 2B receptor, and many others listed in Table 1 above. This is generally attained by hybridization of the anti-sense oligonucleotides to coding (sense) sequences of a targeted messenger RNA (mRNA), as is known in the art. The exogenously administered agents of the invention decrease the levels of mRNA and protein encoded by the target gene and/or cause changes in the growth characteristics or shapes of the thus treated cells. See, Milligan et al. (1993); Helene, C. and Toulme, J. Biochim. Biophys. Acta 1049, 99-125 (1990); Cohen, J. S. D., Ed., Oligodeoxynucleotides as Anti-sense Inhibitors of Gene Expression; CRC Press: Boca Raton, FL (1987), the relevant portion of which is hereby incorporated in its entirety by reference. As used herein, "anti-sense oligonucleotide" is generally a short sequence of synthetic nucleotide that (1) hybridizes to any segment of a mRNA encoding a targeted protein under appropriate hybridization conditions, and which (2) upon hybridization causes a decrease in gene expression of the targeted protein. The terms Ades-adenosine@ (desA) and Ades-thymidine@ (desT) refer to oligonucleotides substantially lacking either adenosine (desA) or thymidine (desT). In some instances, the des T sequences are naturally occurring, and in others they may result from substitution of an undesirable nucleotide (A) by another one lacking its undesirable activity. In the present context, the substitution is generally accomplished by substitution of A with a Auniversal base@, as is known in the art. The mRNA sequence of the targeted protein may be derived from the nucleotide sequence of the gene expressing the protein. For example, the sequence of the genomic human adenosine A, receptor and that of the rat and human adenosine A, receptors are known. See, US Pat. No. 5,320,962; Zhou, F., et al., Proc. Nat'l Acad. Sci. (USA) 89 :7432 (1992); Jacobson, M.A., et al., U.K. Pat. Apple. No. 9304582.1. The sequence of the adenosine A,, receptor gene is also known. See, Salvatore, C. A., Luneau, C. J., Johnson, R. G. and Jacobson, M., Genomics (1995), the relevant portion of which is hereby incorporated in its entirety by reference. The sequences of many of the exemplary target genes are also known. See, GenBank, NIH. The sequences of those genes whose sequences are not yet available may be obtained by isolating the target segments applying technology known in the art. Once the sequence of the gene, its RNA and/or the protein are known, an anti-sense oligonucleotides may be produced according to this invention as described above to reduce the production of the targeted protein in accordance with standard techniques. In one aspect of this invention, the anti-sense oligonucleotide has a sequence which specifically binds to a portion or segment of an mRNA molecule which encodes a protein associated with a disease or condition associated with impeded breathing, lung inflammation, airway obstruction, bronchitis, and the like. One effect of this binding is to reduce or even prevent the translation of the corresponding mRNA and, thereby, reduce the available amount of target protein in the subject's lung. In one preferred embodiment of this invention, the phosphodiester residues of the anti-sense oligonucleotide are modified or substituted. Chemical analogs of oligonucleotides with modified or substituted phosphodiester residues, e.g., to the methylphosphonate, the phosphotriester, the phosphorothioate, the phosphorodithioate, or the phosphoramidate, which increase the in vivo stability of the oligonucleotide are particularly preferred. The naturally occurring phosphodiester linkages of oligonucleotides are susceptible to some degree of degradation by cellular nucleases. Many of the residues proposed herein, on the contrary, are highly resistant to nuclease degradation. See Milligan et al., and Cohen, J. S. D., supra. In another preferred WO 00/09525 PCT/US99/17712 EPI-109 9 embodiment of the invention, the oligonucleotides may be protected from degradation by adding a "3'-end cap" by which nuclease-resistant linkages are substituted for phosphodiester linkages at the 3' end of the oligonucleotide. See, Tidd, D. M. and Warenius, H.M., Be. J. Cancer 60: 343-350 (1989); Shaw, J.P. et al., Nucleic Acids Res. 19: 747-750 (1991), the relevant section of which are incorporated in their entireties herein by reference. Phosphoramidates, phosphorothioates, and methylphosphonate linkages all function adequately in this manner for the purposes of this invention. The more extensive the modification of the phosphodiester backbone the more stable the resulting agent, and in many instances the higher their RNA affinity and cellular permeation. See Milligan, et al., supra. Thus, the number of residues which may be modified or substituted will vary depending on the need, target, and route of administration, and may be from I to all the residues, to any number in between. Many different methods for replacing the entire phosphodiester backbone with novel linkages are known. See, Millikan et al, supra. Preferred backbone analogue residues include phosphorothioate, methylphosphonate, phosphotriester, thioformacetal, phosphorodithioate, phosphoramidate, formacetal boranophosphate, 3'-thioformacetal, 5'-thioether, carbonate, 5'-N-carbamate, sulfate, sulfonate, sulfamate, sulfonamide, sulfone, sulfite., 2'-0 methyl, sulfoxide, sulfide, hydroxylamine, methylene(methylimino) (MMI), and methyleneoxy(methylimino) (MOMI) residues. Phosphorothioate and methylphosphonate-modified oligonucleotides are particularly preferred due to their availability through automated oligonucleotide synthesis. See, Millikan et al, supra. Where appropriate, the agent of this invention may be administered in the form of their pharmaceutically acceptable salts, or as a mixture of the anti-sense oligonucleotide and its salt. In another embodiment of this invention, a mixture of different anti-sense oligonucleotides or their pharmaceutically acceptable slats is administered. The agents of this invention have the capacity to attenuate the expression of one target mRNA and/or to enhance or attenuate the activity of one pathway. By means of example, the present method may be practiced by identifying all possible deoxyribonucleotide segments which are low in thymidine (T) or deoxynucleotide segments low in adenosine (A) of about 7 or more mononucleotides, preferably up to about 60 mononucleotides, more preferably about 10 to about 36 mononucleotides, and still more preferably about 12 to about 21 mononucleotides, in a target mRNA or a gene, respectively. This may be attained by searching for mononucleotide segments within a target sequence which are low in, or lack thymidine (RNA), a nucleotide which is complementary to adenosine, or that are low in adenosine (gene), that are 7 or more nucleotides long. In most cases, this search typically results in about 10 to 30 such sequences, I. e. naturally lacking or having less than about 40% adenosine, anti-sense oligonucleotides of varying lengths for a typical target mRNA of average length, i. e., about 1800 nucleotides long. Those with high content of T or A, respectively, may be fixed by substitution of a universal base for one or more As. The agent(s) of this invention may be of any suitable length, including but not limited to, about 7 to about 60 nucleotides long, preferably about 12 to about 45, more preferably up to about 30 nucleotides long, and still more preferably up to about 21, although they may be of other lengths as well, depending on the particular target and the mode of delivery. The agent(s) of the invention may be directed to any and all segments of a target RNA. One preferred group of agent(s) includes those directed to an mRNA region containing a junction between an intron and an exon. Where the agent is directed to an intron/exon junction, it may either entirely overlie the junction or it may be sufficiently close to the junction to inhibit the splicing-out of the intervening exon during processing of precursor mRNA to mature mRNA, e.g. with the 3' or 5' terminus of the anti-sense oligonucleotide being positioned within about, for example, within about 2 to 10, preferably about 3 to 5, nucleotide of the intron/exon junction. Also preferred are anti-sense oligonucleotides which overlap the initiation codon, and those near the 5' and 3' termini of the coding region. Table 2 below provides a selected number of targets to which the agents of the invention are effectively applied. Others, however, may also be targeted.
WO 00/09525 PCT/US99/17712 EPI-109 10 Table 2:Cancer Targets Transforming Therapy Oncogenes Targets ras thymidylate synthetase src thymidylate synthetase myc dihydrofolate reductase bcl-2 thymidine kinase deoxycytidine kinase ribonucleotide reductase A group of preferred targets for the treatment of cancer are genes associated with any of different types of cancers, or those generally known to be associated with malignancies, whether they are regulatory or involved in the production of RNA and/or proteins. Examples are transforming oncogenes, including, but not limited to, ras, src, myc, and bcl-2, among others. Other targets are those to which present cancer chemotherapeutic agents are directed to, such as various enzymes, primarily, although not exclusively, thymidylate synthetase, dihydrofolate reductase, thymidine kinase, deoxycytidine kinase, ribonucleotide reductase, and the like. The present technology is particularly useful in the treatment of cancer ailments given that traditional cancer therapies are fraught with the unresolved problem of selectively killing cancer cells while preserving normal living cells from the devastating effects of treatments such as chemotherapy, radiotherapy, and the like. The present technology provides the ability of selectively attenuating or enhancing a desired pathway or target. This approach provides a significant advantage over standard treatments of cancer because it permits the selection of a pathway, including primary, secondary and possibly tertiary targets, which are not generally expressed simultaneously in normal cells. Thus, the present agent may be administered to a subject to cause a selective increase in toxicity within tumor cells that, for instance, express all three targets while normal cells that may expresses only one or two of the targets will be significantly less affected or even spared. A group of preferred targets for the treatment of cancers are genes associated with different types of cancers, or those generally known to be associated with malignancies, whether they are regulatory or involved in the production of RNA and/or proteins. Examples are transforming oncogenes, including, but not limited to, ras, src, myc, and bcl-2, among others. Other targets are those to which present cancer chemotherapeutic agents are directed to, such as various enzymes, primarily, although not exclusively, thymidylate synthetase, dihydrofolate reductase, thymidine kinase, deoxycytidine kinase, ribonucleotide reductase, and the like. In one embodiment, at least one of the mRNAs to which the MTA oligo of the invention is targeted encodes a protein such as transcription factors, stimulating and activating factors, intracellular and extracellular receptors and peptide transmitters in general, interleukins, interleukin receptors, chemokines, chemokine receptors, endogenously produced specific and non-specific enzymes, immunoglobulins, antibody receptors, central nervous system (CNS) and peripheral nervous and non-nervous system receptors, CNS and peripheral nervous and non-nervous system peptide transmitters, adhesion molecules, defensines, growth factors, vasoactive peptides and receptors, and binding proteins, among others; or the mRNA is corresponding to an oncogene and other genes associated with various diseases or conditions. Examples of target proteins are eotaxin, major basic protein, preproendothelin, eosinophil cationic protein, P-selectin, STAT 4, MIP-la, MCP-2, MCP-3, MCP-4, STAT 6, c-mas, NF-IL-6, cyclophillins, PDG2, cyclosporin A-binding protein, FK5-binding protein, fibronectin, LFA-1 (CDlla/CD18), PECAM-1, C3bi, PSGL-1,CD-34, substance P, p150,95, Mac-1 (CDllb/CD18), VLA-4, CD-18/CDlla, CDllb/CD18, C5a, CCR1, CCR2, CCR4, CCR5, and LTB-4, among others. Others are, however, suitable, as well. In another embodiment, at least one of the mRNAs to which the MTA oligo is targeted encodes intracellular and extracellular receptors and peptide transmitters such as sympathomimetic receptors, parasympathetic receptors, GABA receptors, adenosine receptors, bradykinin receptors, insulin receptors, glucagon receptors, prostaglandin receptors, thyroid receptors, androgen receptors, anabolic receptors, estrogen receptors, progesterone receptors, receptors associated with the coagulation cascade, adenohypophyseal receptors, WO 00/09525 PCT/US99/17712 EPI-109 11 adenohypophyseal peptide transmitters, and histamine receptors (HisR), among others. However others are also contemplated. The encoded sympathomimetic receptors and parasympathomimetic receptors include acetylcholinesterase receptors (AcChaseR) acetylcholine receptors (AcChR), atropine receptors, muscarinic receptors, epinephrine receptors (EpiR), dopamine receptors (DOPAR), and norepinephrine receptors (NEpiR), among others. Further examples of encoded receptors are adenosine A, receptor, adenosine A 2 B receptor, adenosine A, receptor, endothelin receptor A, endothellin receptor B, IgE high affinity receptor, muscarinic acetylcholine receptors, substance P receptor, histamine receptor, CCR-1 CC chemokine receptor, CCR-2 CC chemokine receptor, CCR-3 CC chemokine receptor (Eotaxin Receptor), interleukin-1p receptor (IL-1pR), interleukin-1 receptor (IL-IR), interleukin-Ip receptor (IL-lpR), interleukin-3 receptor (IL-3R), CCR-4 CC chemokine receptor, cysteinyl leukotriene receptors, prostanoid receptors, GATA-3 transcription factor receptor, interleukin-1 receptor (IL-1R), interleukin-4 receptor (IL-4R), interleukin-5 receptor (IL-5R), interleukin-8 receptor (IL-8R), interleukin-9 receptor (IL-9R), interleukin-11 receptor (IL-11R), bradykinin B2 receptor, sympathomimetic receptors, parasympathomimetic receptors, GABA receptors, adenosine receptors, bradykinin receptors, insulin receptors, glucagon receptors, prostaglandin receptors, thyroid receptors, androgen receptors, anabolic receptors, estrogen receptors, progesterone receptors, receptors associated with the coagulation cascade, adenohypophyseal receptors, and histamine receptors (HisR). Others are also contemplated even though not listed herein. The encoded enzymes for development of the MTA oligos of the invention include synthetases, kinases, oxidases, phosphatases, reductases, polysaccharide, triglyceride, and protein hydrolases, esterases, elastases, and , polysaccharide, triglyceride, lipid, and protein synthases, among others. Examples of target enzymes are tryptase, inducible nitric oxide synthase, cyclooxygenase (Cox), MAP kinase, eosinophil peroxidase, p2 adrenergic receptor kinase, leukotriene c-4 synthase, 5-lipooxygenase, phosphodiesterase IV, metalloproteinase, tryptase, CSBP/p38 MAP kinase, neutrophil elastase, phospholipase A2, cyclooxygenase 2 (Cox-2), fucosyl transferase, chymase, protein kinase C, thymidylate synthetase, dihydrofolate reductase, thymidine kinase, deoxycytidine kinase, and ribonucleotide reductase, among others. Any enzyme associated with a disease or condition , however, is suitable as a target for this invention. Suitable encoded factors for application of this invention are, among others, Nf6B transcription factor, granulocyte macrophage colony stimulating factor (GM-CSF), AP-1 transcription factor, GATA-3 transcription factor, monocyte activating factor, neutrophil chemotactic factor, granulocyte/macrophage colony-stimulating factor (G-CSF), NFAT transcription factors, platelet activating factor, tumor necrosis factor a (TNF a), and basic fibroblast growth factor (BFGF). Additional factors are also within the invention even though not specifically mentioned. Suitable adhesion molecules for use with this invention include intracellular adhesion molecules 1 (ICAM-1), 2 (ICAM-2) and 3 (ICAM-3), vascular cellular adhesion molecule (VCAM), endothelial leukocyte adhesion molecule-1 (ELAM-1), neutrophil adherence receptor, mad CAM-1, and the like. Other known and unknown factors (at this time) may also be targeted herein. Among the cytokines, lymphokines and chemokines preferred are interleukin-1 (IL-1), interleukin-1p (IL-I)interleukin-3 (IL-3), interleukin-4 (IL-4), interleukin-5 (IL-5), interleukin-8 (IL-8), interleukin-9 (IL-9), interleukin-1l (IL-i1),CCR-5 CC chemokine, and Rantes. Others, however, may also be targeted, as they are known to be involved in specific diseases or conditions to be treated, or for their generic activities, such as inflammation. Examples of defensins for the practice of this invention are defensin 1, defensin 2, and defensin 3, and of selectins are ax4pl selectin, a4p7 selectin, LFA-1 selectin, E-selectin, P-selectin, and L-selectin. Examples of oncogenes, although not an all inclusive list, are ras, src, myc, and bcl-2. Others, however, are also suitable for use with this invention. In another preferred embodiment, the composition and formulations further comprise one or more surfactants. Suitable surfactants or surfactant components for enhancing the uptake of the anti-sense oligonucleotides of the invention include synthetic and natural as well as full and truncated forms of surfactant protein A, surfactant protein B, surfactant protein C, surfactant protein D and surfactant Protein E, di-saturated phosphatidylcholine (other than dipalmitoyl), dipalmitoylphosphatidylcholine, phosphatidylcholine, phosphatidylglycerol, phosphatidylinositol, phosphatidylethanolamine, phosphatidylserine; phosphatidic acid, WO 00/09525 PCT/US99/17712 EPI-109 12 ubiquinones, lysophosphatidylethanolamine, lysophosphatidylcholine, palmitoyl-lysophosphatidylcholine, dehydroepiandrosterone, dolichols, sulfatidic acid, glycerol-3-phosphate, dihydroxyacetone phosphate, glycerol, glycero-3-phosphocholine, dihydroxyacetone, palmitate, cytidine diphosphate (CDP) diacylglycerol, CDP choline, choline, choline phosphate; as well as natural and artificial lamelar bodies which are the natural carrier vehicles for the components of surfactant, omega-3 fatty acids, polyenic acid, polyenoic acid, lecithin, palmitinic acid, non-ionic block copolymers of ethylene or propylene oxides, polyoxypropylene, monomeric and polymeric, polyoxyethylene, monomeric and polymeric, poly (vinyl amine) with dextran and/or alkanoyl side chains, Brij 35, Triton X-100 and synthetic surfactants ALEC, Exosurf, Survan and Atovaquone, among others. However, others may also be employed. These surfactants may be useed either as single or part of a multiple component surfactant in a formulation, or as covalently bound additions to the 5' and/or 3' ends ofthe anti-sense oligonucleotides (oligos). The agents administered in accordance with this invention are preferably designed to be anti-sense to target genes and/or mRNAs related in origin to the species to which it is to be administered. When treating humans, the agents are preferably designed to be anti-sense to a human gene or RNA. The agents of the invention encompass oligonucleotides which are anti-sense to naturally occurring DNA and/or RNA sequences, fragments thereof of up to a length of one (1) base less than the targeted sequence, preferably at least about 7 nucleotides long, oligos having only over about 0.02%, more preferably over about 0.1%, still more preferably over about 1%, and even more preferably over about 4% adenosine nucleotides, and up to about 30%, more preferably up to about 15%, still more preferably up to about 10% and even more preferably up to about 5%, adenosine nucleotide, or lacking adenosine altogether, and oligos in which one or more of the adenosine nucleotides have been replaced with so-called universal bases, which may pair up with thymidine nucleotides but fail to substantially trigger adenosine receptor activity. Examples of human sequences and fragments, which are not limiting, of anti-sense oligonucleotide of the invention are the following fragments as well as shorter segments of the fragments and of the full gene or mRNA coding sequences, exons and intron-exon junctions encompassing preferably 7, 10, 15, 18 to 21, 24, 27, 30, n-l nucleotides for each sequence, where n is the sequence's total number of nucleotides. These fragments may be selected from any portion of the longer oligo, for example, from the middle, 5'- end, 3'- end or starting at any other site of the original sequence. Of particular importance are fragments of low adenosine nucleotide content, that is, those fragments containing less than or about 30%, preferably less than or about 15%, more preferably less than or about 10%, and even more preferably less than or about 5%, and most preferably those devoid of adenosine nucleotide, either by choice or by replacement with a universal base in accordance with this invention. The agent of the invention includes as a most preferred group sequences and their fragments where one or more adenosines present in the sequence have been replaced by a universal base (B), as exemplified here. Similarly, also encompassed are all shorter fragments of the B-containing fragments designed by substitution of B(s) for adenosine(s) (A(s)) contained in the sequences, fragments thereof or segments thereof, as described above. A limited list of sequences and fragments is provided below. Some of the examples of anti-sense oligonucleotide sequence fragments target the initiation codon of the respective gene, and in some cases adenosine is substituted with a universal base adenosine analogue denoted as "B", which lacks ability to bind to the adenosine A, and/or A 3 receptors. In fact, such replacement nucleotide acts as a "spacer". In fact, in all examples provided, whether it is an A. or a B written in, either one of these may be substituted. In fact, what this means is that if an A is present A denotes adenosine or any universal base which may substitute for it, and id B is written in it also signifies adenosine or any universal base. Many of the examples shown below provide one such sequence and many fragments overlapping the initiation codon, preferably wherein the number of nucleotides n is about 7, about 10, about 12, about 15, about 18, about 21 and up to about 28, about 35, about 40, about 50, about 60. It may also be generally said that for the exemplary sequences B is adenosine or a universal base as well as an adenosine A2a receptor agonist, or adenosine Al, A2b or A3 receptor antagonist. Human Receptor-related Antisense Polvnucleotide 5'-GGCGGCCTGG AAAGCTGAGA TGGAGGGCGG CATGGCGGGC ACAGGCTGGG C TGCrillCT TTCTGGGCC TCTGTGGTCT GTITITCT GGCCCTGCTG GGGCGCTCTC CGCCGCCCGC CTGGCTCCCG GBGCCCBTGB TGGGCBTGCC GTGGTTCTG CCCTCCTTG GCTGCCGTGC CCGCTCCCCG GCCTCCTGGC GGGTGGCCGT TGGGCCCGTG TTCCCCTGGG GCCTGGGGCT CCCTTCTCTC GCCCT7CT7G CTGGGCCTCT GCTGCTGCTG GTGCTGTGGC CCCCGTACA CCGAGGAGCC CATGATGGGC ATGCCACAGA CGACAGGCGT BCBCCGBGGB GCCCBTGBTG GGCBTGCCBC BGBCGBCBGG C GGC GCC GTG CCG CGT CTT GGT GGC GGC GG GTT CGC GCC CGC GCG GGG CCC CTC CGG TCC GTT CGC GCC CGC GCG GGG CCC WO 00/09525 PCT/US99/17712 EPI-109 13 CTC CGG TCC CGG GTC GGG GCC CCC CGC GGC C GCC TCG GGG CTG GGG CGC TGG TGG CCG GG CCG CGC CTC CGC CTG CCG CTr CTG GCT GGG CCC CGG GCG CCC CCT CCC CTC TrG CTC GGG TCC CCG TG ACA GCG CGT CCT GTG TCT CCA GCA GCA TGG CCG GGC CAG CTG GGC CCC BCB GCG CGT CCT GTG TCT CCB GCB GCB TGG CCG GGC CBG CTG GGC CCC ACA GAG CAG TGC TGT TGT TGG GCA TCT TGC CTT CCC AGG G BCB GBG CB TGC TGT TGT TGG' GCB TCT TGC CTT CCC BGG GCC CTT TTC TGG TGG GGT GGT GCT GTT GTT GGG CTT TCT TCT GTT CCC BCB GBG CBG TGC TGT TGT TGG GCB TCT TGC CTr CCC BGG GCC CTT TTC TGG TGG GGT GGT GCT GTT GTT GGG C TIT CTT CTG TTC CC TTT CCC CTG GGT CIT CC CTC CTG CTC TTT TTT C ATT TGC TCT CCT ATT ACT TTC TGT GTC CAT 'IT TTC ATT AAC CGA GCT GT BTT TGC TCT CCT BTT BCT TTC TGT GTC CBT TTT TTC BTF BBC CGB GCT GT GCC TGT GTC TGT CCT CCT GCT TCG TTC CTC TCG TTC CTG CTT GGT GCC CTT GCC G GTC CTG CTC CTC CGG GCT GTG G GTC GTG GCC CTG GCT CCG GCT GGT GGG CTC CCC TGG CCT TCG CTG GCT GGC GOC GTG C GGG TCT TGC TCT GGG CCT GGC TGT GGC CGT GGT TGG GGG TCT TC GCT GCC TCC GTT TGG GTG GC TCT CTG AAT ATT GAC CTT CCT CCA TGG CGG TCC TGC TTG GAT TCT CCC GA TCT CTG BBT BTT GBC CTT CCT CCB TGG CGG TCC TGC TTG GBT TCT CCC GB GCC TT CCT GGT TCT CTT GTT GTT TTT GGG GTT TGG CTT ACA GTA GAG TAG GGG ATT CCA TGG CAG GAG CCA TCT TCT TCA TGG ACT CC TTC AAG GAG ACC TTA GGT TTC TGA GGG ACT GCT AAC ACG CCA TCT GGA GC BCB GTB GBG TBG GGG BTT CCB TGG CBG GBG CCB TCT TCT TCB TGG BCT CC TTC BBG GBG BCC TTB GGT TTC TGB GGG BCT GCT BBC BCG CCB TCT GGB GC GTT GTT TTT GGG GTT TGG CTT GCC TTT CCT GGT TCT CTT BCB GTB GBG TBG GGG BT CCB TGG CBG GBG CCB TCT TCT TCB TGG BCT CC TTC BBG GBG BCC TTB GGT TTC TGB GGG BCT GCT BBC BCG CCB TCT GGB GC GCC TGT GTC TGT CCT CCT GCT TCG TTC CTC TCG TTC CTG CTT GGT GCC CTT GCC G GTC CTG CTC CTC CGG GCT GTG G GTC CTC GCC CTG GCT CCG GCT GGT GGG CTC CCC TGG CCT TCG CTG GCT GGC GOC GTG C CCC BGB BCG BGB CCC GGB CCG BCB GGC CGT GGT TGG GGG TCT TC GCT GCC TCC GTT TGG GTG GC GAT CTC TGA ATA TFGA CCT TCC ATG GCG GTC CTG CTT GGA GBT CTC TGB BTB TTGB CCT TCC BTG GCG GTC CTG CTT GGB TCT GGG GTG TCC TGG CCT TCG TGG TTC CTC TTC CTT CGT TG CCG TCC GCG GGG GCC CCC GGG CCT GGC TGC GCT CCT GCC CCG CCT CTT TCC CGG GCT CTT GCG CTG GGG GGT GCT CC CGT GTG TTT GCG CCC TC CTC CTG GTC GCG CTT GTC GTT TTG GGG CCG GCT TG CCC GCC TCC CGG CGC CTG GCC CGG CC TTC CTG GGC TGC GTG CGC GTT CTG TTC TC TTC CTG GCT CTG GGG TGT CCT GGC CTT CGT GGT TCC TCT TCC TTC GTT TGC CGT CCG CGG GGG CCC CCG GGC CT GGC TGC GCT CCT GCC CCG CCT CTT TCC CGG GCT CTT GCG CTG GGG GGT GCT CCC GTG TGT TTG CGC CCT CCT CCT GGT CGC GCT TGT CGT TIT GG GGC CGG CIT TGC CCG CCT CCC GGC GCC TGG CCC GGC CTT CCT GGG CTG CGT GCG CGT TCT GTT CTT CTT CCT GGC GCA GGA GAC AGG GCA GGG CGA TCA GGA GCA GCG TGA GCC AAA GGA GGA CCA TCG GGA ACG CAG CTC CGG AAC GCA GGA CAG AGG TGC CGC BGG BGB CBG GGC BGG GCGBTC BGG BGC BGC GTG BGC CBB BGG BGG BCC BTC GGG BBC GCB GCT CCG GBB CGC BGG BCB GBG GTG CC TCT GCC CTG TCC GCC GGC TCT TCG GTG GCT CGG CCC CGC TCC TTG TCT TGC CGC GGG TTG GTT CCT GGG CCT GGT TCT TGC GGG CGT 'TC GGT CTG CTG GCT GGT CTG GGC CCG CGG TGC GOC GGG TGG CTT GCT GTT CTG CCT GGG CTC TCC CCT CTC CTC CTT TTC TCC CTT CCT CTG TCT TGC CTC CTT CCT CTG GGT CCT CTT GGC CTG GGC GCT CTT CCC CTC GGG CGG CTG CGG GCG CTC GTG CTG CCT GGT CCG CTC CCT GGG GGT GCT CCT TCC CIT TCC CCG CTC GTG GGG TTT GCG GGG CTG GGC TGC CCT GGG GGG TCT GGG CCT TTT GGG GTC GGC TGG CTG CTG CTT CGG GCC GCC TGG GCT TCC CTG TGC CCC TTT CCT CTG CTG GGT CCC CCT CCC GTT CCA AGC TGC ACC GCA CAG ACC GGC GCT ACA GGA CAG AGC CAG GCA AGC ACC CAT GGG GAT CCA GGC CCA GCT GTT CCB BGC TGC BCC GCB CBG BCC GGC GCT BCB GGB CBG BGC CBG GCB BGC BCC CBT GGG GBT CCB GGC CCB GCT G CTCAGTGGCC CCCAAAAGGA TGAGTAATAC ATGCGCCACG ATGATCATAT CCTTTTTACT ATGAGGCCGT GTCTGTCGTG TCTTTCCTTT GCTCTTGGTG TGTCTTTGCT GTGCCCTGCC TCTCTGCCCG TGTCTGTCGT GTCTTTCCTT TGCTCTTGGT GTGTCTTTGC TGTGCCCTGC CTCTCTGCC CGTGTCTGTC GTGTCTTTCC TITGCTCTTG GTGTGTCTTT GCTGTGCCCT GCCTCTCTGC GGGGGTGGCT TCCTGCCGCG TCTCTGGGCC GTCCCGTCCC TCGGCCCCGC GCCGCGCTCG GCTCCTCTCC CTCTGGCCCG GCTCGGGGCG GGGCGGGGCG GTGGGCGGGC GGCGCTGCCC TGCGCGCGGC GCTGGCCCCT GCTGGCCGTC GGCTGCGCGC TGCTGGCTGC CCTGCTGGCC GCGCCGGGGC CTGTCCGCCT CTGCGGGCGC TGTCTCCTGG CTTGTCTTCC GGCTCTTCTG CTGGGGTGGG GCTGGGCGGC CGGCCCGGTG CTGGGGCTCC TCGGGGGGGG GGGCTCTTCC GGGCTGTCTC CCTCCGGGGC GGGGGTTTCT GGCCGTGGGG GTCTTGCCTG GCCTCCGGGC TCCTGCTTGT CTTGCCTTCC TTCTITGGTC GGTTGTGGCT CGGGGCTCCG TGGGTCCCTG GCGCCCGTTT GTGTTTTGTC TTTTCCCCTG GCGTCCCTGT GCCCCTCTCC TCTCCTTCCT CTGCTTCTCG CTCTCCTTTG TGGGGCCCTC CCTGCTGCTC TTGGTTTTGG GCTTITTTTC TCTTCCTCCT TTTTCGTGCG TGGGCCTCC GCACGCCTCT TGCCACCTCC TGCGCAGGGC AGCGCCTTGG GGCCAGCGCC GCTCCCGGCG CGGCCAGCAG GGCAGCCAGC AGCGCGCAGC CGACGGCCAG CATGCTTCCT CCTCGGCTAC CACTCCATGG TCCCGCAGAG GCGGACAGGC GCBCGCCTC TTGCCBCCTC CTGCGCBGGG CBGCGCCTTG GGGCCBGCGC CGCTCCCGGC GCGGCCBGCB GGGCBGCCBG CBGCGCGCBG CCGBCGGCCB GCBTGCTTCC TCCTCGGCTB CCBCTCCBTG GTCCCGCBGB GGCGGBCBGG C GCTGCCCGGC GGGGTGTGCG CTTGGCGCTC CCGTGCTCGG 'TCTCTGTCT CCCGGTCCCC CTTGCCTGGC GTCTCGGGCC TTCGTCCTCT TCCTCTTCTT CCTTCCGCTC CGTGGGGGCT GCTiTGGTGGG GGCCTGTGCCT CGGGGTCCCG GGGCTTCTGG CCCTTGCCGT TCATGGTGGC TAGGTGGGGC GTTCBTGGTG GCTBGGTGGG GC GGG GTG GGT BGG CCG TGT CTG GGGGTT GGC CBT GTT GGT TGC CTCT TGG TGG TGC GCC GGG CGCG TCT TGG CTT TCT TCT CCT TCG GGC CCT CGG GCC GGT GCT TGT GGGCT CCT CCC GGG CGG CCT CCC CGG GCG GGG GCT TCT TGGCG CTG GCG GGG GGG CCT CCTGCT CTG TGG CTG GGC GTT CCT TGG TGT TCT GGG TGGTGG CGG GCG TGG TGG CCT CTG TGGGGG CCC GCG GCT GCB GGG GTTG CCT GTC TGC TTC GTCCTT TGC GCT CCC GGG CCG CCGGG GTG GGT AGG CCG TGT CTG GGGGTT GGC CAT GTT GGT TGC CGGG CCC GCG GCT GCA GGG G ACAGGGGCTG TAATCTTCATC WO 00/09525 PCT/US99/17712 EPI-109 14 TGCAGGTGGC ATGCCAGTGA AATTTAGATC ATCAAAATCC CACATCTGTG GATCTGTAAT ATTTGACATG TCCTCTTCAG TTCAGCAAT GGTT7GATCT AACTGAAGCA CCGGCCAGGB CBGGGGCTGT BBTCTTCBTC TGCBGGTGGC BTGCCBGTGB BBTTBGBTC BTCBBBBTCC CBCBTCTGTG GBTCTGTBBT BTTTGBCBTG TCCTCTTCBG TTTCBGCBB TGGTTTGBTC TBBCTGBBGC BCCGGCCBGG TGGCTCGGTG CTTCTGCCCC TGTTGTTGCG GCGCTCGGTT GGTGTGGCCC CTGTGGTGCT TCGTTTCCCC CrCTFTCTCT TrGTTCGGGG GTCTTGTGG CGGGCTGCTT GTCTCGTTCC GCCCTGTCGG GCGGGAAGCC TCTCTCCTCT CCCCAGATC CGCGACAGGC CGCAGGCAAG AACCAGCGCA ACCAGGGCGC GTCCGCACAG ACTTGGAGGC GGCTGCATGC TGCTACCTGC TCCAGAAGCG TCCGGTGGCC GCCGCGCC CTGTCGGGCG GGBBGCCTCT CTCCTCTCCC CBGBTCCGCG BCBGGCCGCB GGCBBGBBCC BGCGCBBCCB GGGCGCGTCC GCBCBGBCTT GGBGGCGGCT GCBTGCTGCT BCCTGCTCGGGCG GGBBGCCTCCG GTGGCCGCCG CGCGTCCGGT GGCCGCCGCG CCTCTCTCCT CTCCCCGTGG CCCTGTCGGG CGGGTCCTGC CGTCCTGTCT CCTTTTCTTT TGCTGTCTTG TCTTCCCGTC TCTGCT GTCTGTCCTC CCCGTCTCCT CCCACTGCTT CTCCCGGGGG CTTCCCCGGC TTCGGGTGGC CGGTGTCCCG GGCTCCGGCG CGGCGGCGGC TTCGGCTGCG GGTGGGTGGC GCGGGCTGCC GGGTCCGCGC GGCGCCTGGG CCCTTGTGCT GcI TIrGCT TGTTCCGTTC TGGCTGCTCC GGTCTGTGTT GTGGTTGTTT TGTTTCTTCT TGGGTGTGGG CCTTGCGGTT TTGGCTGTGG GCCCTTGGG GCCTTGGCTT CTGGCTCGTC TGTCCTCCCC GTCTCCTCCC ACTGCTFCT CCCGGGGGCT TCCCCGGCTT CGGGTGGCCG GTGTCCCGGG CTCCGGCGCG GCGGCGGCTT CGGCTGCGGG TGGGTGGCGC GGGCTGCCGG GTCCGCGCGG CGCCTGGGCC CTTGTGCTGC TFITGCTTG TTCCGTTCTG GCTGCTCCGG TCTGTGTTGT GGTTGTITTG TCTrCTTG GGTGTGGGCC TTGCGGT GGCTGTGGGC CCTTTGGGGC CTTGGCTTCT GGCTCCAT CCACATGATT GCTTAGATTT GTGCTGTATC TCTCAGGATT ATCACTGATT ACACATCCAA CCAGTGCCAG CCAAAAGGAT GCCCTGAGGC AAAGGGTITC CATCTTGAGG CAAATTTGAG GACBTCCBC BTGBTTGCTT BGBTTTGTGC TGTBTCTCTC BGGBTTBTCB CTGBTTBCBC BTCCBBCCBG TGCCBGCCBB BBGGBTGCCC TGBGGCBBBG GGTTTCCBTC TTGBGGCBBB TTTGBGGBGGGCTBBGBT GBTCCBCBTC BCTBCCBCGT TGCCCBCCBC BGBGGTCBCC BCBBTGBCCG TGTBGGCBGC TGCCCBBBGG BCBBTGCC BGGCTGGTTG CBCGBBCTGB TGGGTTCCG BGGTGTTBGT GGBGBTGTTT GGGGBGBGGT CTGBGTCCBC CGGGBGGBCG TTBTCCBTT CGBBGCTBGG CGGTBBBGCC CTBCTBTCTG TBCBCBBCCC CCCTCTGCBG CBGBGTCCTG TCGTGGCGCC TGGGGCTCBG GGTCCGGGC TAAGATGATC CACATCACTA CCACGTTGCC CACCACAGAG GTCACCACAA TGACCGTGTA GGCAGCTGCC CAAAGGACAA TTGCCAGGC TGGTTGCACG AACTGATTGG GTrCCGAGGT GTTAGTGGAG ATGTITGGGG AGAGGTCTGA GTCCACCGGG AGGACGTTAT CCATTTCGAA GCTAGGCGGT AAAGCCCTAC TATCTGTACA CAACCCCCCT CTGCAGCAGA GTCCTGTCGT GGCGCCTGGG GCTCAGGGTC CGTCCTGTCG TGGCGCCTGG GGCTCTTCTT TTGTGGGCTC TTTGGTGGCT GTGGCTGTGG TCTCTGTGGT TGCTGCCCTG GGTCTGGGGG TGTGGCCTTG GGGCCGTCCT CTGGCTCCTC CTCGTGGGCC CCC GGTGBCBTTG BGCBTGTCGG CGCGGTCCCG TTBBGBGTGG GCCCGCCAGC CCAGCCACTC CACTTGGGGG CGGGTGGCCA GCACGAACAG CACCCAGAGG AAGGGGGGCG GCCCAGAAGG GCAGCCCGCA GGCCAGGATC AGGTCTGCTG CGGCCGGAGA TAATGGCATT CACCACGCGG CGGCCCAGCG CACGCCGCGC ATCCGGCCCG GGTTCTGACC TGCAGCCCCC GTCTCCTrGG CATrCCTGGG CCCCAGTCAC TCCTCTCCCT GCCCCCCTTG CTGGGGCAGG GACGGGGTG BCBTTGBGCB TGTCGGCGCG GTCCCGTTBB GBGTGGGCCC GCCAGCCCAG CCACTCCACT TGGGGGCGGG TGGCCAGCAC GAACAGCACC CAGAGGAAGG GGGGCGGCCC AGAAGGGCAG CCCGCAGGCC AGGATCAGGT CTGCTGCGGC CGGAGATAAT GGCATTCACC ACGCGGCGGC CCAGCGCACG CCGCGCATCC GGCCCGGGTT CTGACCTGCA GCCCCCGTCT CCTTGGCATT CCTGGGCCCC AGTCACTCCT CTCCCTGCCC CCCTTGCTGG GGCAGGGACG GCCGTGTTGT CBGTGGTGCT GCCCGTTTGB GGTBTGGCGC TCCBCCBBTT CCCTTTTCTC CTTGTTTTCC GTTTCTCTTG CCGTCTGTGG TT ATGCCGCCCT CCATCTCAGC TTICCAGGCC GCCTACATCG GCATCGAGGT GCTCATCGCC CTGGTCTCTG TGCCCGGGAA CGTGCTGGTG ATCTGGGCGG TGAAGGTGAA CCAGGCGCTG CGGGATGCCA CCTTCTGCTT CATCGTCTCG CTGGCGGTGG CTGATGTGGC CGTGGGTGCC CTGGTCATCC CCCTCGCCAT CCTCATCAAC ATTGGGCCAC AGACCTACTT CCACACCTGC CTCATGGTTG CCTGTCCGGT CCTCATCCTC ACCCAGAGCT CCATCCTGGC CCTGCTGGCA ATTGCTGTGG ACCGCTACCT CCGGGTCAAG ATCCCTCTCC GGTACAAGAT GGTGGTGACC CCCCGGAGGG CGGCGGTGGC CATAGCCGGC TGCTGGATCC TCTCCTTCGT GGTGGGACTG CCCCTATGT TTGGCTGGAA CAATCTGAGT GCGGTGGAGC GGGCCTGGGC AGCCAACGGC AGCATGGGGG AGCCCGTGAT CAAGTGCGAG TTCGAGAAGG TCATCAGCAT GGAGTACATG GTCTACTTCA ACTrCTTTGT GTGGGTGCTG CCCCCGCTTC TCCTCATGGT CCTCATCTAC CTGGAGGTCT TCTACCTAAT CCGCAAGCAG CTCAACAAGA AGGTGTCGGC CTCCTCCGGC GACCCGCAGA AGTACTATGG GAAGGAGCTG AAGATCGCCA AGTCGCTGGC CCTCATCCTC TTCCTCTTTG CCCTCAGCTG GCTGCCT'G CACATCCTCA ACTGCATCAC CCTCTTCTGC CCGTCCTGCC ACAAGCCCAG CATCCTTACC TACATTGCCA TCTTCCTCAC GCACGGCAAC TCGGCCATGA ACCCCATFGT CTATGCCTTC CGCATCCAGA AGTTCCGCGT CACCTTCCTF AAGATTTGGA ATGACCATTT CCGCTGCCAG CCTGCACCTC CCATTGACGA GGATCTCCCA GAAGAGAGGC CTGATGACTA G ATGAGTGTCA GAAGTGTGAA GGGTGCCTGT TCTGAATCCC AGAGCCTCCT CTCCCTCTGT GAGGCTGGCA GGTGAGGAAG GGTFTAACCT CACTGGAAGG AATCCCTGGA GCTAGCGGCT GCTGAAGGCG TCGAGGTGTG GGGGCACTTG GACAGAACAG TCAGGCAGCC GGGAGCTCTG CCAGCTTTGG TGACCTTGGG CCGGGCTGGG AGCGCTGCGG CGGGAGCCGG AGGACTATGA GCTGCCGCGC GTrGTCCAGA GCCCAGCCCA GCCCTACGCG CGCGGCCCGG AGCTCTGTTC CCTGGAACT TGGGCACTGC CTCTGGGACC CCTGCCGGCC AGCAGGCAGG ATGGTGCTrG CCTCGTGCCC CTTGGTGCCC GTCTGCTGAT GTGCCCAGCC TGTGCCCGCC ATGCCGCCCT CCATCTCAGC TTTCCAGGCC GCCTACATCG GCATCGAGGT GCTCATCGCC CTGGTCTCTG TGCCCGGGAA CGTGCTGGTG ATCTGGGCGG TGAAGGTGAA CCAGGCGCTG CGGGATGCCA CCTrCTGCTT CATCGTGTCG CTGGCGGTGG CTGATGTGGC CGTGGGTGCC CTGGTCATCC CCCTCGCCAT CCTCATCAAC ATTGGGCCAC AGACCTACTT CCACACCTGC CTCATGGTTG CCTGTCCGGT CCTCATCCTC ACCCAGAGCT CCATCCTGGC CCTGCTGGCA ATTGCTGTGG ACCGCTACCT WO 00/09525 PCTIUS99/17712 EPI-109 15 CCGGGTCAAG ATCCCTCTCC GGTACAAGAT GGTGGTGACC CCCCGGAGGG CGGCGGTGGC CATAGCCGGC TGCTGGATCC TCTCCTTCGT GGTGGGACTG ACCCCTATGT TTGGCTGGAA CAATCTGAGT GCGGTGGAGC GGGCCTGGGC AGCCAACGGC AGCATGGGGG AGCCCGTGAT CAAGTGCGAG TrCGAGAAGG TCATCAGCAT GGAGTACATG GTCTACTTCA ACTTCTTGT GTGGGTGCTG CCCCCGCTTC TCCTCATGGT CCTCATCTAC CTGGAGGTCT TCTACCTAAT CCGCAAGCAG CTCAACAAGA AGGTGTCGGC CTCCTCCGGC GACCCGCAGA AGTACTATGG GAAGGAGCTG AAGATCGCCA AGTCGCTGGC CCTCATCCTC TTCCTCTG CCCTCAGCTG GCTGCCTTTG CACATCCTCA ACTGCATCAC CCTCTTCTGC CCGTCCTGCC ACAAGCCCAG CATCCTTACC TACATTGCCA TCTTCCTCAC GCACGGCAAC TCGGCCATGA ACCCCATTGT CTATGCCTTC CGCATCCAGA AGTTCCGCGT CACCTTCCTT AAGATTGGA ATGACCATTT CCGCTGCCAG CCTGCACCTC CCATTGACGA GGATCTCCCA GAAGAGAGGC CTGATGACTA GACCCCGCCT TCCGCTCCCA CCAGCCCACA TCCAGTGGGG TCTCAGTCCA GTCCTCACAT GCCCGCTGTC CCAGGGGTCT CCCTGAGCCT GCCCCAGCTG GGCTGTTGGC TGGGGGCATG GGGGAGGCTC TGAAGAGATA CCCACAGAGT GTGGTCCCTC CACTAGGAGT TAACTACCCT ACACCTCTGG GCCCTGCAGG AGGCCTGGGA GGGCAAGGGT CCTACGGAGG GACCAGGTGT CTAGAGGCAA CAGTGTTCTG AGCCCCCACC TGCCTGACCA TCCCATGAGC AGTCCAGCGC TTCAGGGCTG GGCAGGTCCT GGGGAGGCTG AGACTGCAGA GGAGCCACCT GGGCTGGGAG AAGGTGCTTG GGCTTCTGCG GTGAGGCAGG GGAGTCTGCT TGTCTTAGAT GTrGGTGGTG CAGCCCCAGG ACCAAGCTTA AGGAGAGGAG AGCATCTGCT CTGAGACGGA TGGAAGGAGA GAGGTTGAGG ATGCACTGGC CTGTrCTGTA GGAGAGACTG GCCAGAGGCA GCTAAGGGGC AGGAATCAAG GAGCCTCCGT TCCCACCTCT GAGGACTCTG GACCCCAGGC CATACCAGGT GCTAGGGTGC CTGCTCTCCT TGCCCTGGGC CAGCCCAGGA TTGTACGTGG GAGAGGCAGA AAGGGTAGGT TCAGTAATCA TTTCTGATGA TTTGCTGGAG TGCTGGCTCC ACGCCCTGGG GAGTGAGCTT GGTGCGGTAG GTGCTGGCCT CAAACAGCCA CGAGGTGGTA GCTCTGAGCC CTCCTTCTTG CCCTGAGCTT TCCGGGGAGG AGCCTGGAGT GTAATTACCT GTCATCTGGG CCACCAGCTC CACTGGCCCC CGTTGCCGGG CCTGGACTGT CCTAGGTGAC CCCATCTCTG CTGCTTCTGG GCCTGATGGA GAGGAGAACA CTAGACATGC CAACTCGGGA GCATTCTGCC TGCCTGGGAA CGGGGTGGAC GAGGGAGTGT CTGTAAGGAC TCAGTGTTGA CTGTAGGCGC CCCTGGGGTG GGTTAGCAG GCTGCAGCAG GCAGAGGAGG AGTACCCCCC TGAGAGCATG TGGGGGAAGG CCTTGCTGTC ATGTGAATCC CTCAATACCC CTAGTATCTG GCTGGGTTIT CAGGGGCTT GGAAGCTCTG TTGCAGGTGT CCGGGGGTCT AGGACTTTAG GGATCTGGGA TCTGGGGAAG GACCAACCCA TGCCCTGCCA AGCCTGGAGC CCCTGTGTTG GGGGGCAAGG TGGGGGAGCC TGGAGCCCCT GTGTGGGAGG GCGAGGCGGG GGAGCCTGGA GCCCCTGTGT GGGAGGGCGA GGCGGGGGAT CCTGGAGCCC CTGTGTCGGG GGGCGAGGGA GGGGAGGTGG CCGTCGGTTG ACCITCTGAA CATGAGTGTC AACTCCAGGA CTTGCTTCCA AGCCCTTCCC TCTGTrGGAA ATTGGGTGTG CCCTGGCTCC CAAGGGAGGC CCATGTGACT AATAAAAAAC TGTGAACCCT CGCATTTGTG TTTTAATAAA AGAATCTGGA AGATAAATAG TCTTGAAGAG AGACAAAGGA AGGAAAATTT AAATCCTrAG ATrCAAGCAG AAGAATTCCA TGTGGAAGGT TTGGGTTGTT GTTGTTGTTG TrTGGTGTGT TTI=GTTT TTITGTTTTT TGTTTr TGAGATGGAG TCTCGCTGTG TTACCGGGAG CGACAGAGCC GCACGGCCGA GTCGAGTCCC AGCCAGCTAC CATCCCTCTG GAGCTTACCG GCCGGCCTTG GCTTCCCCAG GAATCCCTGG AGCTAGCGGC TGCTGAAGGC GTCGAGGTGT GGGGGCACTT GGACAGAACA GTCAGGCAGC CGGGAGCTCT GCCAGCTTTG GTGACCTTGG GTGCTTGCCT CGTGCCCCTT GGTGCCCGTC TGCTGATGTG CCCAGCCTGT GCCCGCCATG CCGCCCTCCA TCTCAGCTTT CCAGGCCGCC TACATCGGCA TCGAGGTGCT CATCGCCCTG GTCTCTGTGC CCGGGAACGT GCTGGTGATC TGGGCGGTGA AGGTGAACCA GGCGCTGCGG GATGCCACCT TCTGCTTCAT CGTGTCGCTG GCGGTGGCTG ATGTGGCCGT GGGTGCCCTG GTCATCCCCC TCGCCATCCT CATCAACATT GGGCCACAGA CCTACTTCCA CACCTGCCTC ATGGTTGCCT GTCCGGTCCT CATCCTCACC CAGAGCTCCA TCCTGGCCCT GCTGGCAATT GCTGTGGACC GCTACCTCCG GGTCAAGATC CCTCTCCGGT ACAAGATGGT GGTGACCCCC CGGAGGGCGG CGGTGGCCAT AGCCGGCTGC TGGATCCTCT CCTFCGTGGT GGGACTGACC CCTATGTTTG GCTGGAACAA TCTGAGTGCG GTGGAGCGGG CCTGGGCAGC CAACGGCAGC ATGGGGGAGC CCGTGATCAA GTGCGAGTTC GAGAAGGTCA TCAGCATGGA GTACATGGTC TACTTCAACT TCTTTGTGTG GGTGCTGCCC CCGCTTCTCC TCATGGTCCT CATCTACCTG GAGGTCTTCT ACCTAATCCG CAAGCAGCTC AACAAGAAGG TGTCGGCCTC CTCCGGCGAC CCGCAGAAGT ACTATGGGAA GGAGCTGAAG ATCGCCAAGT CGCTGGCCCT CATCCTCTTC CTCTTTGCCC TCAGCTGGCT GCCTTGCAC ATCCTCAACT GCATCACCCT CTTCTGCCCG TCCTGCCACA AGCCCAGCAT CCTTACCTAC ATTGCCATCT TCCTCACGCA CGGCAACTCG GCCATGAACC CCATTGTCTA TGCCTTCCGC ATCCAGAAGT TCCGCGTCAC CTTCCTTAAG ATGGAATG ACCATTCCG CTGCCAGCCT GCACCTCCCA TTGACGAGGA TCTCCCAGAA GAGAGGCCTG ATGACTAGAC CCCGCCTTCC GCTCCCACCG CCCACATCCA GTGGGGTCTC AGTCCAGTCC TCACATGCCC GCTGTCCCAG GGGTCTCCCT GAGCCTGCCC CAGCTGGGCT GTTGGCTGGG GGCATGGGGG AGGCTCTGAA GAGATACCCA CAGAGTGTGG TCCCTCCACT AGGAGTTAAC TACCCTACAC CTCTGGGCCC TGCAGGAGGC CTGGGAGGGC AAGGGTCCTA CGGAGGGACC AGGTGTCTAG AGGCAACAGT GTTCTGAGCC CCCACCTGCC TGACCATCCC ATGAGCAGTC CAGAGCTTCA GGGCTGGGCA GGTCCTGGGG AGGCTGAGAC TGCAGAGGAG CCACCTGGGC TGGGAGAAGG TGCTTGGGCT TCTGCGGTGA GGCAGGGGAG TCTGCTTGTC TTAGATGTTG GTGGTGCAGC CCCAGGACCA AGCTTAAGGA GAGGAGAGCA TCTGCTCTGA GACGGATGGA AGGAGAGAGG TTGAGGATGC ACTGGCCTGT TCTGTAGGAG AGACTGGCCA GA CCCAGCCCCG AGGCTCAGAA GCGGCAGGCG GAGGCGCGGT CCGGGCGCTA TGGCCATGCC CGGCGGGTCT CACGCGGCTG CCCCTCGCCC GGCGCGCCTT CGGTAGGGGG CGCCCGGGGC CCAGCTGGCC CGGCCATGCT GCTGGAGACA CAGGACGCGC TGTACGTGGC GCTGGAGCTG GTCATCGCCG CGCTTTCGGT GGCGGGCAAC GTGCTGGTGT GCGCCGCGGT GGGCACGGCG AACACTCTGC AGACGCCCAC CAACTACTTC CTGGTGTCCC TGGCTGCGGC CGACGTGGCC GTGGGGCTCT TCGCCATCCC CTTTGCCATC ACCATCAGCC TGGGCTTCTG CACTGACTTC TACGGCTGCC TCTTCCTCGC CTGCTTCGTG CTGGTGCTCA CGCAGAGCTC CATCTTCAGC CTTCTGGCCG TGGCAGTCGA CAGATACCTG GCCATCTGTG TCCCGCTCAG GTATAAAAGT TTGGTCACGG GGACCCGAGC AAGAGGGGTC ATTGCTGTCC TCTGGGTCCT TGCCTTTGGC ATCGGATTGA CTCCATTCCT GGGGTGGAAC AGTAAAGACA GTGCCACCAA CAACTGCACA WO 00/09525 PCTIUS99/1 7712 EPI-109 16 GAACCCTGGG ATGGAACCAC GAATGAAAGC TGCTGCCTTG TGAAGTGTCT CTTGAGAAT GTGGTCCCCA TGAGCTACAT GGTATATIC AA'IFCI=G GGTGTGTTCT GCCCCCACTG C17ATAATGC TGGTGATCTA CA'TrAAGATC TrCCTGGTGG CCTGCAGGCA G=TCAGCGC ACTGAGCTGA TGGACCACTC GAGGACCACC CTCCAGCGGG AGATCCATGC AGCCAAGTCA CTGGCCATGA rrGTGGGGAT T=GCCCTG TGCTGGTTAC CTGTGCATGC TGTTAACTGT GTCACTC1T TCCAGCCAGC TCAGGGTAAA AATAAGCCCA AGTGGGCAAT GAATATGGCC A'FrCTITCTGT CACATGCCAA TTCAcflTGTC AATCCCATTG TCTATGCTTA CCGGAACCGA GAC'=CCGcT7 ACACTFFCA CAAAATTATC TCCAGGTATC 'FrCrCTGCCA AGCAGATGTC AAGAGTGGGA ATGGTCAGGC TGGGGTACAG CCTGCTCTCG GTGTGGGCCT ATGATGTAGG CTCTCGCCTC TTCCAGGAGA AGATACAAAT CCACAAGAAA CAAAGAGGAC ACGGCTGGYI7 'FFCATrGTGA AAGATAGCTA CACCTCACAA GGAAATGGAC TGCCTCTCTTr GAGCACT7CC CTGGAGCTAC CACGTATCTA GCTAATATGT ATGTGTCAGT AGTAGCACCA AGGATTGACA AATATATI1A TGATCTATrC AGCTGCT=~ ACTGTGTGGA TTATGCCAAC AGCT7GAATG GATTCTAACA GACTCT=G TI1T1AAAAG TCTGCCFIGT TTATGGTGGA AAATrACTGA AACTATITA CTGTGAAACA GTGTGAACTA TFATAATGCA AATACTIT= AACTTAGAGG CAATGGAAAA ATAAAAGTTG ACTGTACTAA AAATGTATAC TlG1TGCCAG GAAGGTGACC TCAAAAATTA AAAGTATAAT TATTCGGCCG GGCATGGTGG CTCACACCTG TANFrCCAGC AC=rGGGAG GCCAAGGCAG GCGGATCACG AGGTCAGGAG 7rCAAAACCA GCCTGTCCAA TATAGTG GGGCAA'TTG YrAGTFATCC GCCGCCACCA AGACGCGGCA CGGCGCCTrGG ACCGGAGGGG CCCCGCGCGG GCGCGAACTI TGGGCTCGGG CGAGTGGGTG GTGCTCCGCC CAGCCCGAGA CGGGCGGGCG CGCGGGCCAA TGGGTGCCGC CTCTrGGCCG CGGGGGGCCC CGACCCGTGG GTCCCGGCCA CCAGCGCCCC AGCCCCGAGG CTCAGAAGCG GCAGGCGGAG GCGCGGTCCG GGCGCTATGG CCATGCCCGG CGGGTCTCAC GCGGCTGCCC CTCGCCCGGC GCGCCT7CGG TAGGGGGCGC CCGGGGCCCA GCTGGCCCGG CCATGCTGCT GGAGACACAG GACGCGCTGT ACGTGGCGCT GGAGCTGGTC ATCGCCGCGC TTTCGGTGGC GGGCAACGTG CTGGTGTGCG CCGCGGTGGG CACGGCGAAC ACTCTGCAGA CGCCCACCAA CTACITCCTG GTGTCCCTGG CTGCGGCCGA CGTGGCCGTG GGGCTCT7CG CCATCCCCTI' TGCCATCACC ATCAGCCTGG GCTGCAC TGAC FFCTAC GGCTGCCTCT TCCTCGCCTG C'FrCGTGCTG GTGCTCACGC AGAGCTCCAT C=CAGCC'F CTGGCCGTGG CAGTCGACAG ATACCTGGCC ATCTGTGTCC CGCTCAGGTA TAAAAGTIG GTCACGGGGA CCCGAGCAAG AGGGGTCA'IT GCTGTCCTCT GGGTCCTTGC CTIGGCATC GGATTGACTC CAT7CCTGGG GTGGAACAGT AAAGACAGTG CCACCAACAA CTGCACAGAA CCCTGGGATG GAACCACGAA TGAAAGCTGC TGCCTTGTGA AGTGTCTCTIT TGAGAATGTG GTCCCCATGA GCTACATGGT ATATTrCAAT r=IGGGT GTGTI'CTGCC CCCACTGCT ATAATGCTGG TGATCTACAT TAAGATCTC CTGGTGGCCT GCAGGCAGCT TCAGCGCACT GAGCTGATGG ACCACTCGAG GACCACCCTC CAGCGGGAGA TCCATGCAGC CAAGTCACTG GCCATGATrG TGGGGA=II TGCCCTGTGC TGGTTACCTG TGCATGCTGT TAACTGTGTC ACTCTTTCC AGCCAGCTCA GGGTAAAAAT AAGCCCAAGT GGGCAATGAA TATGGCCATT CTTCTGTCAC ATGCCAAT7C AG~FrGTCAAT CCCATrGTCT ATGC17ACCG GAACCGAGAC TTCCGCTACA CITTCACAA AATrATCTCC AGGTATCTC TCTGCCAAGC AGATGTCAAG AGTGGGAATG GTCAGGC1TGG GGTACAGCCT GCTCTCGGTG TGGGCCTATG ATCTAGGCrC TCGCCTCT7C CAGGAGAAGA TACAAATCCA CAAGAAACAA AGAGGACACG GCTGGTFFC ATI7GTGAAAG ATAGCTACAC CTCACAAGGA AATGGACTGC CTrCTCT7GAG CACTCCCTG GAGCTACCAC GTATCTAGCT AATATGTATG TGTCAGTAGT AGGCTCCAAG GATI'GACAAA TATA'T7ATG ATCTATrCAG CTGC'II1AC TGTGTGGATT ATGCCAACAG CTTGAATGGA FrCTAACAGA CTC7TFGTT 'IMrAAAAGTC TGCC rGTr ATGGTGGAAA ATTACTGAAA CTA'mACT GTGAAACAGT GTGAACTAT7 ATAATGCAAA TACTfITAA CT7AGAGGCA ATGGAAAAAT AAAAGT7GAC TGTACTAAAA ATG GAATTCCCAG ATGGGCAGAG GTGGCTGGGC TGGTGACCCT AAGTGTGTCT CCTGCC'=A TTCTCTCTAG TGGGTrATTC M~CATGTGG TATI1GCCT ACAGCATGCT GTGT7GGAC ACAAACCCCT TTCCTGGYTf TCTCTGACCC AGC7GAGATG GACTGATTCC AAAAGAACTC ACCTATGTAC TGGGGTAGGG GAGGGAGGGT TI1TGCAGT ATrAACTAA GGTrCAAAGA GTGCTATATA GTGAGAAAGG CTIIT' ITIrTI TITITGGCA GAGTGCTGCC TCCTAGAAAT TrCTCTTGGT AACTTCCTrC TCTGAAGCAC AGATAAAGAA AACAATTACA GTAGAAACAT TTATGAGGGA CACATTGGAG GCCGATGAAG C7=hCAAGT TCCAGCAGTG CAGGGATGTG GGCAGAACTG ACATrGGAAA ATACTAGAAT GATGGAAATT CAGflGGAGA GGACTGCCCT ITFAATGTC TGGGGAGTCT GCTCAGGGAG AAATGACAAG TCrGGCGGGG ACAAGTATGG GA=TGGTAA GACTTGGATC AACTTGGGAT ACAGGGTGGG GGTCGGGAGT GGAATCAATG AATGATGCCA GAGCAGATCA ACTAACAAGA GGACCCTGAT GAGCCCCAGG CAGAGGCGTC TCCCTrATGC CCCACTCTGA AGTG T7GTF AGTAAACACC AGAACGCCAT TGT7GTTACT GCTGAATFP ATITGGGCT GTACATA'IM AGATGCTI'AA GGTAAAAATG ATAAAGCCCTr CAAGCCACTG TGTGGGTT7G GGTCCAAGTG TTCC=CTG CTGCCTCTCT AACACGCCTG GTrAAAATAA TCCC'=GGA TGGTGCTGAG AAGCACCTGA ACCAAGTGGG TCCCCAAATA ACAATGGCGT GCAAGTGTCT GGTTCCCAGA AGTrGGTGAC TAGGTAAGCA GGTTCAGGGA GAGGGGGCTG ATrCCCAGAC AGTCGCCTGT TCCTGCGGGG ATGGGGCTGA GGCTTGGGGA ATGTGGGCAG GAGGATATGC CA=~GAT7C TGTTGCACAC GTrCT1TCC crrcirG TATGTCTGGT CA'ITCTGCTA TTrCTGTCGIr CCTCACATAG GTTGGACATF GGCCGGCTGC CAGCATAAGT GCCAGTGTGA =F~GCTAGG TGTGAGCTGA GAAAGAGAGG TGGAGGCTAA GCAGGTGTGA TGCTITCTCAG AGGTGCTGAG TflTGCCCT TCTGAGCAGG GAATCTTGC TTATCCCT= GACCAAGGAT CTFGCTGCA AAGGCTGGGT ATCGGCTGTG CTCAGCAAAG CGTCAACTCG TGCAAGAACT TAGCAGGAAT AGTTCTGGCT AAGG'17AGGA GGCTGCCACC AAAGTCTCTI' TIGTTCCT CTGCTTr]CC CG'ITGCCTC CTATCATGA GATCTI1TG CTAAGCTGGC AGAAAGA'FrG CATAGTCAGT GcTrCCAGCT CTGCTCCCAC CTGATCCTGC ACTGTCCTCT GGTCCCTGAA TGAATGAACT CTGATACCCA ATCTGTCTC GAGCCT]~cTC TATGCCACTC ATGGCTCCTC 'TCTGCFCT7 TCCATCITI TGCTGAGAGT TCTGAGCTCT GTACICCTC Y[GGCCCATC TCAC'ICCTG AAACACCCCT GAAGAGGGTr GC'IrATC=G ATGGAACTCA AAAAGCCAAA AAGCTGCAGG CAGAGGCGT GAGGACATCT GT7GGGGAA CTAAGAGCAG CAGCAC1TC AGATTCAGTC CATATAGAGC TGTCCTACAG CAT!TCTGGAA ACT'rGAGGAT GTGCGGTGCA TAAAGGGGCT GGAAGTGACC CACCTGTGAT GAGCCCITTC TAAGGAGAAG GGITICCAAG WO 00/09525 PCTIUS99/1 7712 EPI-109 17 AGATCACCCC ACCAGAAAAG GGTAGGAATG AGCAAGTTGG GAA=TIAGA CTGTCACTGC ACATGGACCT CTGGGAAGAC GTCTGGCGAG AGCTAGGCCC ACTGGCCCTA CAGACGGATC FrGCTGGCTC ACCTGTCCCT GTGGAGGTTC CCCTGGGAAG GCAAGATGCC CAACAACAGC ACTGCTCTGT CA'FrGGCCAA TGTTACCTAC ATCACCATGG AAATITCAT TGGACTCTGC GCCATAGTGG GCAACGTGCT GGTCATCTGC GTGGTCAAGC TGAACCCCAG CCTGCAGACC ACCACCTFICT ATF-TCAT7GT CTCTCTAGCC CTGGCTGACA 'PTGCTGTTGG GGTGCTGGTC ATGCC'TIGG CCATI'GTTGT CAGCCTGGGC ATCACAATCC ACTTCTACAG CTGCCTFF ATGACflGCC TACTGCTrAT CTTACCCAC GCCTCCATCA TGTC=TGCT GGCCATCGCT GTGGACCGAT ACTTGCGGGT CAAGCTTACC GTCAGGTAGC CTGCGGCGTG GGGTGGGCAG CAATrGAGcJC AGCTGGGAAA TGAGGCTACA AAGCCAGAGC CTGCTGAATFT 'FrA'I=GGA CTGTACATAT TI7AGATG=T AAGGTAAAAA TGATAAAGCC CTCAAGCCAC TGTGTGGGT-r GGGTCCAAGT GTFTCCTrGCT GCTGCCTCTC TAACACGCCT GGTTAAAATA ATCCCT=GG ATGGTGCTGA GAAGCACCTG AACCAAGTGG GTCCCCAAAT AACTATGGCG TGCAAGTGTC TGGTTCCCAG AAGITGGTGA CTAGGTAAGC GACTCAGGGA GAGGGGCTGA TFTCCCAGACA GTCGCCTGTT CCTGCTGGGA TGGGGCTGAG GCYTGGGGAA TGTGGGCAGG AGGATATGCC A'I=GAT7CT GT7GCACACG TTC'r=CCC 'ITrCTGT ATGTCTGGTC ATTICTGCTAT TCTGTCGTrC CTCACATAGG TTGGACATrG GCCGGCTGCC AGCATAAGTG CCAGTGTGAT T17GCTAGGG TGTGAGCTGA GAAAGAGAGG TGGAGGCTAA GCAGGTGTGA TGCTrCTCAG AGGTGCTGAG TITTGCCCT TCTGAGCAGG GAATC=rGC TrATCCCIT GACCAAGGAT CTI7GCTCCA AAGGCTGGGT ATCGGCTGTG CTCAGCAAAG CGTCAACTCG TGCAAGAACT TAGCAGGAAT AGTTCTGGCr AAGGTTAGGA GGCTGCCACC AAAGTCr= I=fGTrCCT CTGCT~rCTCC CGTITGCCTC CTFATCATGA GATCTTTG CTAAGCTGGC AGAAAGATTG CATAATCAGT GCTICCAGCT CCGCTCCCAC CTGATCCTGC ACTGTCCTCT GGTCCCTGAA TGAATGAACT CTGATACCCA ATCTTGTCTC GAGCCTFCTC TATGCCACTC ATGGCTCCTC rrCTGCTCrT TCCATC'T TGCTGAGAGT TACTGAGCTC TGTACTrCCT C'FrGGCCCAT CTCA=TCCT GAAACACCCC TGAAGAGGGT TG=TATC-TT GATGGAACTC AAAAAGCCAA AAAGCTGCAG GCAGAGGCGT TGAGGACATC TGTTTrGGGGA ACTAAGAGCA GCAGCACTT CAGATTCAGT CCATATAGAG CTGTCCTACA GCA117CTGGA AACTFIGAGGA TGTGCGGTGC ATAAAGGGGC TGGAAc3TGAC CCACCTGTGA TGAGCCC1T CTAAGGAGAA GGGIMCCAA GAGATCACCC CACCAGAAAA GGGTAGGAAT GAGCAAG'FrG GGAATTAG ACTGTCACTG CACATGGACC TCTGGGAAGA CGTCTGGCGA GAGCTAGGCC CACTGGCCCT ACAGACGGAT CTGCTGGCT CACCTGTCCC TGTGGAGGTT CCCCTGGGAA GGCAAGATGC CCAACAACAG CACTGCTCTG CGAATTCGGG GGACATCTGT TTGGGGAACT AAGAGCAGCA GCACI=CAG ATrCAGTCCA TATAGAGCTG TCCTACAGCA TT'CTGGAAAC TT7GAGGATGT GCGGTGCATA AACGGGCTGG AAGTGACCCA CCTGTGATGA GCCCI=CTA AGGAGAAGGG 'ITTCCAAGAG ATCACCCCAC CAGAAAAGGG TAGGAATGAG CAAGUrGGGA AT1TAGACT GTCACTGCAC ATGGACCTCT GGGAAGACGT CTrGGCGAGAG CTAGGCCCAC TGGCCCTACA GACGGATCTT GCTGGCTCAC CTGTCCCTGT GGAGGTTCCC CTGGGAAGGC AAGATGCCCA ACAACAGCAC TGCTCTGTCA 'FrGGCCAATG 'FrACCTACAT CACCATGGAA ATI=CATrG GACTCTGCGC CATAGTGGGC AACGTGCTGG TCATCTGCGT GGTCAAGCTG AACCCCAGCC TGCAGACCAC CACCT17CTAT TrCA~rGTCT CTCTAGCCCT GGCTGACATT GCTGTI'GGGG TGCTGGTCAT GCCTIGGCC ATfGTTGTCA GCCTGGGCAT CACAATCCAC 7rCTACAGCT GCCTITAT GACTGCCTA CTGCTI'ATCT TrACCCACGC CTCCATCATG TC=TGCTGG CCATCGCTGT GGACCGATAC PTGCGGGTCA AGCTrACCGT CAGATACAAG AGGGTCACCA CTCACAGAAG AATATGGCTG GCCCTGGGCC ITrGCTGGCT GGTGTCA'FFC CTGGTGGGAT TGACCCCCAT GTTGGCTGG AACATGAAAC TGACCTCAGA GTACCACAGA AATGTCACCT TCCTTrCATG CCAA'Tr7G r TCCGTCATGA GGATGGACTA CATGGTATAC TTCAGCTTCC TCACCTGGAT TFCATCCCC CTGGTrGTCA TGTGCGCCAT CTATCT~rGAC ATCYT1ACA TCArrCGGAA CAAACTCAGT CTGAACT7AT CTAACTCCAA AGAGACAGGT GCA=TIATG GACGGGAG'IT CAAGACGGCT AAGTCCT7GT TTCTGGTCT 'ITCTTG'F~r GCTCTGTCAT GGCTGCCTI' ATCTCTCATC AACTGCATCA TCTAC1TAA TGGTGAGGTA CCACAGCTTG TGCTGTACAT GGG3CATCCTG CTGTCCCATG CCAACTCCAT GATGAACCCT ATCGTCrATG CCTATAAAAT AAAGAAG'FrC AAGGAAACCTr ACCTITIGAT CCTCAAAGCC TGTGTGGTCT GCCATCCCTC TGATrTn'G GACACAAGCA TTGAGAAGAA TTCTGAGTAG 7rATCCATCA GAGATGACTC TGTCTCKI1TG ACCT7CAGAT TCCCCATCAA CAAACACTTG AGGGCCTGTA TGCCTGGGCC AAGGGAYIT TACATCCTTG ATTA=TCCA CTGAGGTGGG AGCATCTCCA GTGCTCCCCA ATTATATCTC CCCCACTCCA CTACTCTCTT CCTCCAC'TC ArT[CCTr TGTCCT1CT CTCTAA'ITrCA GTGTITGGA GGCCTGACT GGGGACAACG TA-frAT7GAT ATTATrGTCT GrrCCrC 7rCCCAATAG AAGAATAAGT CATGGAGCCT GAAGGGTGCC TAGTTGACTI ACTGACAAAA GGCTCTAGTT GGGCTGAACA TGTGTGTGGT GGTGACTCAT 'FICCATGCCA TTGTGGAATT GAGCAGAGAA CCTGCTCTCG GAGGATGCCT AGGAGATGTT GGGAACAGAA GAAATAAACT GAGMIIAAGG GGGACTFAAA CTGCTGAAT!? C CAGATrCACA AACTGCAGGA CTGGGCAGGG AGCAGACAGT GAGCAAACGC CAGCAGGGCT GCTGTGAATT TGTGTAAGGA TTGAGGGACA G'FrGC'I=C AGCATGGGCC CAGGAATGCC AAGGAGACAT CTATGCACGA CCTrGGGAAA TGAG'TTGATG TCTCCGGTAA AACACCGGAG ACTAA'FrCCT GCCCTGCCCA A=IrGCAGG GAGCATGGCT GTGAGGATGG GGTGAACTCA CGCACAGCCA AGGACTCCAA AATCACAACA GCA'I1ACTGT TC'FrAITI'GC TGCCACACCT GAGCCAGCCT GCTCCTrCCC AGGAGTGGAG GAGGCCTGGG GGGAGGGAGA GGAGTGACTG AGCT'TCCCTC CCGTGTGTrC TCCGTCCCTG CCCCAGCAAG ACAACTTAGA TCTCCAGGAG AACTGCCATC CAGCITGGT GCAATGGCTG AGTGCACAAG TGAGTTG'FrG CCCTGGGTTT CTFFAATCTA TTCAGCTAGA ACT=GAAGG ACAANITF GCAT'TAATAA AGGTTAAGCC CTGAGGGGTC CCTGATAACA ACCTGGAGAC CAGGATIIA TGGCTCCCCT CACTGATGGA CAAGGAGGTC TGTGCCAAAG AAGAATCCAA TAAGCACATA 'FrGAGCACTr GCTGTATATG CAGTA FTGAG CACTGTAGGC AAGACCCAAG AAAGAGAAGG AGCCATCTCC ATCTTGAAGG AACTCAAAGA CTCAAGTGGG AACGACTGGG CACTGCCACC ACCAGAAAGC TGTrCGACGA GACGGTCGAG CAGGGTGCTG TGGGTGATAT GGACAGCAGA AGGGGGAGAC CAAGG'FrCCA GCTCAACCAA TAACTA'ITGC ACAACCACCT GTCCCTGCCT CAGTrCC= TTFATGTAACA TGAAGTCG'Vf GTGAGGGTI'A AAGGCAGTAA CAGGTATAAA GTACTTAGAA AAGCAAAGGG TGCTACGTAC ATGTGAGGCA TCATI'ACGCA GACGTAACTG GGATATG'II WO 00/09525 PCT/US99/17712 EPI-109 18 ACTATAAGGA AAAGACACTG AGGTCTAGAA ATAGCTCCGT GGAGCAGAAT CAGTATTGGG AGCCGGTGGC GGTGTGAAGC ACCAGTGTCT GGCACACAGT AGGTGCTCAT TGGCTCCC7F CCACCTGTCA TTCCCACCAC CCTGAGGCCC CAACCGCCAC ACACACAGGA GCATTTGGAG AGAAGGCCAT GTCTTCAAAG TCTGATGT GATGAGGCAG AGGAAGATAT TTCTAATCGG TCTGCCCAG AGGATCACAG TGCTGAGACC CCCCACCACC AGCCGGTACC TGGGAAGGGG GAGAGTGCAG GCCTGCTCAG GGACTGTTCC TGTCTCAGCA ACCAAGGGAT TGTTCCTGTC AATCAATGGT TrATTGGAAG GTGGCCCAGT ATGAGCCCTA GAAGAGTGTG AAAAGGAATG GCAATGGTGT TCACCATCGG CAGTGCCAGG GCAGCACTCA TTCACTTGAT AAATGAATAT TTATTAGCTG GTTGGAGAGC TAGAACCTGG AGAGCTAGAA CCTGGAGAAC TAGAACCTGG AGGGCTAGAA CCTGGAGAGG CTAGAACCAA GAAGGGCTAG AACCTGGAGG GGCTAGAACC TAGAGAAGCT AAAACCTGAG CTAGAAGCTG GAGGACTAGA ACCTGGAGGG CTGGAATCTG AAGGGCTAGA ACCTGGAGGG CTGGAATCTG GAGAGCTAGA ACCTGGAGGG CTAGAACCTG GAGGGCTAGA ACCTAGAAGG GCTAGAACCT GGAGGGCTGG AATCTGGAGA GCTAGAACCT GGAGGGCTAG AACCTGGAGG GCTAGAACCT AGAAGGGCTA GAACCTGGAG GGCTAGAACC TGGCAGGTrA GAACCTAGAA GGGCTAGAAC CTGGAGAGCC AGAACCTGGA GGGCTAGAAC CTGGAAGGGC TAGAACCTGT AGAGCTAGAA CATGGAGAGC TAGAACCCGG CAGGCTAGAA CCTGGCAAGC TAGAACCTGG AGGGAATGAA CCTGGAGGGC TAGAACCTGG AGAATGAGAA AAATTACAT GGCAAAGAGC CCATAAATCC TGACCAATCC AACTCTGAAT TAAAGCAA AAGCGTGAAA AAAAAGATTC CCTCCTTACC CCCAACCCAC TClTIT 1CC CACCACCCAC TCTCCTCTGC CTCAGTAAGT ATCTGGAGGA AGAAAACAGG TGAAAGAAGA AGTAAAAACC ATTAGTATT AGTATTAGAA TGAAGTCAAA CTGTGCCACA CATGGTGAAT GAAAAAAAAA AAAAAGAGGC TGTGTTTGT CACACAGGGC AGTCATTCAG CACCAGAGCA CGTGATGGTC TGAGACTCTC TTAGGAGCAG AGCTCTGCCG CAATGGCCAT GTGGGGATCC ACACCTGGTC TGAGGGGCAA CTGAGTCTGC GGGAGAAGAG CGGCCCTATG CATGGTGTAG ATGCCCTGAT AAAGAACATC TGTCCTGTGA AAGACTCAAT GAGCTGTTAT GTTGTAAACA GGAAGCATT CACATCCAAA CGAGAAAATC ATGTAAACAT GTGTCTfTC TGTAGAGCAT AATAAATGGA TGAGGTTIT GCAAAAAAAA AAAAAAAAA ATGCCGCCCT CCATCTCAGC 'TCCAGGCC GCCTACATCG GCATCGAGGT GCTCATCGCC CTGGTCTCTG TGCCCGGGAA CGTGCTGGTG ATCTGGGCGG TGAAGGTGAA CCAGGCGCTG CGGGATGCCA CCTTCTGCTT CATCGTCTCG CTGGCGGTGG CTGATGTGGC CGTGGGTGCC CTGGTCATCC CCCTCGCCAT CCTCATCAAC ATTGGGCCAC AGACCTACTr CCACACCTGC CTCATGGTTG CCTGTCCGGT CCTCATCCTC ACCCAGAGCT CCATCCTGGC CCTGCTGGCA ATTGCTGTGG ACCGCTACCT CCGGGTCAAG ATCCCTCTCC GGTACAAGAT GGTGGTGACC CCCCGGAGGG CGGCGGTGGC CATAGCCGGC TGCTGGATCC TCTCCTTCGT GGTGGGACTG ACCCCTATGT TrGGCTGGAA CAATCTGAGT GCGGTGGAGC GGGCCTGGGC AGCCAACGGC AGCATGGGGG AGCCCGTGAT CAAGTGCGAG TTCGAGAAGG TCATCAGCAT GGAGTACATG GTCTACTTCA ACTTCTTTGT GTGGGTGCTG CCCCCGCTTC TCCTCATGGT CCTCATCTAC CTGGAGGTCT TCTACCTAAT CCGCAAGCAG CTCAACAAGA AGGTGTCGGC CTCCTCCGGC GACCCGCAGA AGTACTATGG GAAGGAGCTG AAGATCGCCA AGTCGCTGGC CCTCATCCTC TTICCTCTTTG CCCTCAGCTG GCTGCCTTG CACATCCTCA ACTGCATCAC CCTCTTCTGC CCGTCCTGCC ACAAGCCCAG CATCCTTACC TACATTGCCA TCTTCCTCAC GCACGGCAAC TCGGCCATGA ACCCCATTGT CTATGCCTTC CGCATCCAGA AGTTCCGCGT CACCTTCCTT AAGATTTGGA ATGACCATT CCGCTGCCAG CCTGCACCTC CCATTGACGA GGATCTCCCA GAAGAGAGGC CTGATGACTA G ATGAGTGTCA GAAGTGTGAA GGGTGCCTGT TCTGAATCCC AGAGCCTCCT CTCCCTCTGT GAGGCTGGCA GGTGAGGAAG GGTTTAACCT CACTGGAAGG AATCCCTGGA GCTAGCGGCT GCTGAAGGCG TCGAGGTGTG GGGGCACTTG GACAGAACAG TCAGGCAGCC GGGAGCTCTG CCAGCTTGG TGACCTTGGG CCGGGCTGGG AGCGCTGCGG CGGGAGCCGG AGGACTATGA GCTGCCGCGC GTTGTCCAGA GCCCAGCCCA GCCCTACGCG CGCGGCCCGG AGCTCTGTTC CCTGGAACTT TGGGCACTGC CTCTGGGACC CCTGCCGGCC AGCAGGCAGG ATGGTGCTTG CCTCGTGCCC CTTGGTGCCC GTCTGCTGAT GTGCCCAGCC TGTGCCCGCC ATGCCGCCCT CCATCTCAGC TTTCCAGGCC GCCTACATCG GCATCGAGGT GCTCATCGCC CTGGTCTCTG TGCCCGGGAA CGTGCTGGTG ATCTGGGCGG TGAAGGTGAA CCAGGCGCTG CGGGATGCCA CCTTCTGCTT CATCGTGTCG CTGGCGGTGG CTGATGTGGC CGTGGGTGCC CTGGTCATCC CCCTCGCCAT CCTCATCAAC ATTGGGCCAC AGACCTAC'TT CCACACCTGC CTCATGGTTG CCTGTCCGGT CCTCATCCTC ACCCAGAGCT CCATCCTGGC CCTGCTGGCA ATTGCTGTGG ACCGCTACCT CCGGGTCAAG ATCCCTCTCC GGTACAAGAT GGTGGTGACC CCCCGGAGGG CGGCGGTGGC CATAGCCGGC TGCTGGATCC TCTCCTTCGT GGTGGGACTG ACCCCTATGT TTGGCTGGAA CAATCTGAGT GCGGTGGAGC GGGCCTGGGC AGCCAACGGC AGCATGGGGG AGCCCGTGAT CAAGTGCGAG TTCGAGAAGG TCATCAGCAT GGAGTACATG GTCTACTTCA ACTTCTTTGT GTGGGTGCTG CCCCCGCTTC TCCTCATGGT CCTCATCTAC CTGGAGGTCT TCTACCTAAT CCGCAAGCAG CTCAACAAGA AGGTGTCGGC CTCCTCCGGC GACCCGCAGA AGTACTATGG GAAGGAGCTG AAGATCGCCA AGTCGCTGGC CCTCATCCTC TFCCTCTG CCCTCAGCTG GCTGCCTTTG CACATCCTCA ACTGCATCAC CCTCTTCTGC CCGTCCTGCC ACAAGCCCAG CATCCTrACC TACATTGCCA TCTTCCTCAC GCACGGCAAC TCGGCCATGA ACCCCATTGT CTATGCCTTC CGCATCCAGA AGTTCCGCGT CACCTTCCTT AAGATTTGGA ATGACCATTT CCGCTGCCAG CCTGCACCTC CCATTGACGA GGATCTCCCA GAAGAGAGGC CTGATGACTA GACCCCGCCT TCCGCTCCCA CCAGCCCACA TCCAGTGGGG TCTCAGTCCA. GTCCTCACAT GCCCGCTGTC CCAGGGGTCT CCCTGAGCCT GCCCCAGCTG GGCTGTTGGC TGGGGGCATG GGGGAGGCTC TGAAGAGATA CCCACAGAGT GTGGTCCCTC CACTAGGAGT TAACTACCCT ACACCTCTGG GCCCTGCAGG AGGCCTGGGA GGGCAAGGGT CCTACGGAGG GACCAGGTGT CTAGAGGCAA CAGTGTTCTG AGCCCCCACC TGCCTGACCA TCCCATGAGC AGTCCAGCGC TTCAGGGCTG GGCAGGTCCT GGGGAGGCTG AGACTGCAGA GGAGCCACCT GGGCTGGGAG AAGGTGCTTG GGCTTCTGCG GTGAGGCAGG GGAGTCTGCT TGTCTTAGAT GTTGGTGGTG CAGCCCCAGG ACCAAGCTTA AGGAGAGGAG AGCATCTGCT CTGAGACGGA TGGAAGGAGA GAGGTTGAGG ATGCACTGGC CTGTTCTGTA GGAGAGACTG GCCAGAGGCA GCTAAGGGGC AGGAATCAAG GAGCCTCCGT TCCCACCTCT GAGGACTCTG GACCCCAGGC CATACCAGGT GCTAGGGTGC CTGCTCTCCT TGCCCTGGGC CAGCCCAGGA TTGTACGTGG GAGAGGCAGA AAGGGTAGGT TCAGTAATCA 'TrCTGATGA TTGCTGGAG TGCTGGCTCC ACGCCCTGGG GAGTGAGCTT GGTGCGGTAG GTGCTGGCCT CAAACAGCCA WO 00/09525 PCT/US99/17712 EPI-109 19 CGAGGTGGTA GCTCTGAGCC CTCCI1'CTTG CCCTGAGCTT TCCGGGGAGG AGCCTGGAGT GTAATTACCT GTCATCTGGG CCACCAGCTC CACTGGCCCC CGTTGCCGGG CCTGGACTGT CCTAGGTGAC CCCATCTCTG CTGCTTCTGG GCCTGATGGA GAGGAGAACA CTAGACATGC CAACTCGGGA GCATTCTGCC TGCCTGGGAA CGGGGTGGAC GAGGGAGTGT CTGTAAGGAC TCAGTGTTGA CTGTAGGCGC CCCTGGGGTG GGTTAGCAG GCTGCAGCAG GCAGAGGAGG AGTACCCCCC TGAGAGCATG TGGGGGAAGG CC'FrGCTGTC ATGTGAATCC CTCAATACCC CTAGTATCTG GCTGGG=F~ CAGGGGC'T GGAAGCTCTG TTGCAGGTGT CCGGGGGTCT AGGA=T1AG GGATCTGGGA TCTGGGGAAG GACCAACCCA TGCCCTGCCA AGCCFGGAGC CCCTGTG F7G GGG3GGCAAGG TGGGGGAGCC TGGAGCCCCT GTGTGGGAGG GCGAGGCGGG GGAGCCTGGA GCCCCTGTGT GGGAGGGCGA GGCGGGGGAT CCTGGAGCCC CTGTGTCGGG GGGCGAGGGA GGGGAGGTGG CCGTCGGTI'G ACCTI'CTGAA CATGAGTGTC AACTCCAGGA CTTGCTTCCA AGCCC=CCC TCTGTTGGAA ATTGGGTGTG CCCTGGCTCC CAAGGGAGGC CCATGTGACT AATAAAAAAC TGTGAACCCT CGCATTTGTG T1TAATAAA AGAATCTGGA AGATAAATAG TCTTGAAGAG AGACAAAGGA AGGAAAATF7 AAATCCT7AG ATrCAAGCAG AAGAA ITCCA TGTGGAAGGT TrGGGTrGIT G'rrGT7GTrG TITGGTGTGT TFITG=I TT7G TIT TGTITITFI TGAGATGGAG TCTCGCTGTG TTACCGGGAG CGACAGAGCC GCACGGCCGA GTCGAGTCCC AGCCAGCTAC CATCCCTCTG GAGCTrACCG GCCGGCCTI'G GCTTCCCCAG GAATCCCTGG AGCTAGCGGC TGCTGAAGGC GTCGAGGTGT GGGGGCACTI GGACAGAACA GTCAGGCAGC CGGGAGCTCT GCCAGCI=G GTGACC'FFGG GTGCTGCCT CGTGCCCCTT GGTGCCCGTC TGCTGATGTG CCCAGCCTGT GCCCGCCATG CCGCCCTCCA TCTCAGC1T CCAGGCCGCC TACATCGGCA TCGAGGTGCT CATCGCCCTG GTCTCTGTGC CCGGGAACGT GCTGGTGATC TGGGCGGTGA AGGTGAACCA GGCGCTGCGG GATGCCACCT TCTGCTTCAT CGTGTCGCTG GCGGTGGCTG ATGTGGCCGT GGGTGCCCTG GTCATCCCCC TCGCCATCCT CATCAACATT GGGCCACAGA CCTACTCCA CACCTGCCTC ATGGITGCCT GTCCGGTCCT CATCCTCACC CAGAGCTCCA TCCTGGCCCT GCTGGCAA'FI GCTGTGGACC GCTACCTCCG GGTCAAGATC CCTCTCCGGT ACAAGATGGT GGTGACCCCC CGGAGGGCGG CGGTGGCCAT AGCCGGCTGC TGGATCCTCT CCYCGTGGT GGGACTGACC CCTATG'IMG GCTGGAACAA TCTGAGTGCG GTGGAGCGGG CCTGGGCAGC CAACGGCAGC ATGGGGGAGC CCGTGATCAA GTGCGAGTTC GAGAAGGTCA TCAGCATGGA GTACATGGTC TACTICAACT T=IIGTGTG GGTGCTGCCC CCGC'PCTCC TCATGGTCCT CATCTACCTG GAGGTCTTCT ACCTAATCCG CAAGCAGCTC AACAAGAAGG TGTCGGCCTC CTCCGGCGAC CCGCAGAAGT ACTATGGGAA GGAGCTGAAG ATCGCCAAGT CGCTGGCCCT CATCCTM~C CTCT=GCCC TCAGCTGGCT GCCITGCAC ATCCTCAACT GCATCACCCT CTrCTGCCCG TCCTGCCACA AGCCCAGCAT CCTTACCTAC ATTGCCATCT TCCTCACGCA CGGCAACTCG GCCATGAACC CCArGTCTA TGCCTCCGC ATCCAGAAGT TCCGCGTCAC CT7CCTTAAG AT-GGAATG ACCAMrCCG CrGCCAGCCr GCACCTCCCA TlrGACGAGGA TCTCCCAGAA GAGAGGCCTG ATGACTAGAC CCCGCCTCC GCTCCCACCG CCCACATCCA GTGGGGTCTC AGTCCAGTCC TCACATGCCC GCTGTCCCAG GGGTCrCCCT GAGCCTGCCC CAGCTGGGCT GT7GGCTGGG GGCATGGGGG AGGCTCTGAA GAGATACCCA CAGAGTGTGG TCCCTCCACT AGGAG'FrAAC TACCCTACAC CTCTGGGCCC TGCAGGAGGC CTGGGAGGGC AAGGGTCCTA CGGAGGGACC AGGTGTCTAG AGGCAACAGT GrCTGAGCC CCCACCTGCC TGACCATCCC ATGAGCAGTC CAGAGCTrCA GGGCTrGGGCA GGTCCTGGGG AGGCTGAGAC TGCAGAGGAG CCACCTGGGC TGGGAGAAGG TGCTGGGcT TCTGCGGTGA GGCAGGGGAG TCTGCYFGTC TTAGATGTTG GTGGTGCAGC CCCAGGACCA AGCTTAAGGA GAGGAGAGCA TCTGCTCTGA GACGGATGGA AGGAGAGAGG YrGAGGATGC ACTGGCUI7iT TCTGTAGGAG AGACTGGCCA GA CCCAGCCCCG AGGCTCAGAA GCGGCAGGCG GAGGCGCGGT CCGGGCGCTA TGGCCATGCC CGGCGGGTCT CACGCGGCTG CCCCTCGCCC GGCGCGCCT7 CGGTAGGGGG CGCCCGGGGC CCAGCTGGCC CGGCCATGCT GCTGGAGACA CAGGACGCGC TGTACGTGGC GCTGGAGCTG GTCATCGCCG CGCTFCGGT GGCGGGCAAC GTGCTGGTGT GCGCCGCGGT GGGCACGGCG AACACTCTGC AGACGCCCAC CAACTACTC CTGGTGTCCC TGGCTGCGGC CGACGTGGCC GTGGGGCTCT TCGCCATCCC C'=GCCATC ACCATCAGCC TGGGCTTCTG CACTGAC'IC TACGGCTGCC TCTTCCTCGC CTGCTCGTG CTGGTGCTCA CGCAGAGCTC CATCTrCAGC CTTCrGGCCG TGGCAGTCGA CAGATACCTG GCCATCTGTG TCCCGCTCAG GTATAAAAGT TTGGTCACGG GGACCCGAGC AAGAGGGGTC ATTGCTGTCC TCTGGGTCCT TGCC1TGGC ATCGGATrGA CTCCAT7CCT GGGGTGGAAC AGTAAAGACA GTGCCACCAA CAACTGCACA GAACCCTrGGG ATGGAACCAC GAATGAAAGC TGCTGCC=G TGAAGTGTCT C'TGAGAAT GTGGTCCCCA TGAGCTACAT GGTATATITC AA=IrC=G GGTGTGTTCT GCCCCCACTG C FrATAATGC TGGTGATCTA CATTAAGATC TTCCTGGTGG CCTGCAGGCA GCT-rCAGCGC ACTGAGCTGA TGGACCACTC GAGGACCACC CTCCAGCGGG AGATCCATGC AGCCAAGTCA CTGGCCATGA TGTGGGGAT =1~GCCCTG TGCTGGTTAC CTGTGCATGC TGYI7AACTGT GTCACTCT= TCCAGCCAGC TCAGGGTAAA AATAAGCCCA AGTGGGCAAT GAATATGGCC A'ITCT7CTGT CACATGCCAA T7CAGTTGTC AATCCCATrG TCTATGCTrA CCGGAACCGA GA=TCCGCT ACACTI=CA CAAAAT7ATC TCCAGGTATC TTCTCTGCCA AGCAGATGTC AAGAGTGGGA ATGGTCAGGC TGGGGTACAG CCTGCTCTCG GTGTGGGCCT ATGATCTAGG CTCTCGCCTC TrCCAGGAGA AGATACAAAT CCACAAGAAA CAAAGAGGAC ACGGCTGGTT TTCMTrGTGA AAGATAGCTA CACCTCACAA GGAAATGGAC TGCCTCTCT GAGCAC=CC CTGGAGCTAC CACGTATCTA GCTAATATGT ATGTGTCAGT AGTAGCACCA AGGATTGACA AATATA1TTA TGATCrTA TC AGCTGC7TI ACTGTGTGGA TrATGCCAAC AGC'TrGAATG GAT7CTAACA GACTCTI'G 7IITAAAAG TCTGCCTIGT TFATGGTGGA AAA'1TACTGA AACTATITA CTGTGAAACA GTGTGAACTA T-fATAATGCA AATAC'r AACTTAGAGG CAATGGAAAA ATAAAAGTrG ACTGTACTAA AAATGTATAC TGT7GCCAG GAAGGTGACC TCAAAAAT7A AAAGTATAAT TATTCGGCCG GGCATGGTGG CTCACACCTG TAA7rCCAGC AUI=GGGAG GCCAAGGCAG GCGGATCACG AGGTCAGGAG T7CAAAACCA GCCTGTCCAA TATAGTG GGGCAAMG 'FFAG'frATCC GCCGCCACCA AGACGCGGCA CGGCGCCTGG ACCGGAGGGG CCCCGCGCGG GCGCGAAC'I TGGGCTCGGG CGAGTGGGTG GTGCTCCGCC CAGCCCGAGA CGGGCGGGCG CGCGGGCCAA TGGGTGCCGC CTCYrGGCCG CGGGGGGCCC CGACCCGTGG GTCCCGGCCA CCAGCGCCCC AGCCCCGAGG CTCAGAAGCG GCAGGCGGAG GCGCGGTCCG GGCGCTATGG CCATGCCCGG CGGGTCTCAC GCGGCTGCCC CTCGCCCGGC GCGC=TCGG TAGGGGGCGC CCGGGGCCCA GCTGGCCCGG WO 00/09525 PCT/US99/1 7712 EPI-109 20 CCATGCTGCT GGAGACACAG GACGCGCTGT ACGTGGCGCT GGAGCTGGTC ATCGCCGCGC TrTCGGTGGC GGGCAACGTG CTGGTGTGCG CCGCGGTGGG CACGGCGAAC ACTCTGCAGA CGCCCACCAA CTAC=CCTG GTGTCCCTGG CTGCGGCCGA CGTGGCCGTG GGGCTCTCG CCATCCCCTI' TGCCATCACC ATCAGCCTGG GCTTCTGCAC TGACTCTAC GGCTGC~FCT TCCTCGCCTG CTTCGTGCTG GTGCTCACGC AGAGCTCCAT C=CAGCCTT CTGGCCGTGG CAGTCGACAG ATACCTGGCC ATCTGTGTCC CGCTCAGGTA TAAAAGTF7G GTCACGGGGA CCCGAGCAAG AGGGGTCAT GCTGTCCTCT GGGTCCTrGC C'FTrGGCATC GGAT7GACrC CATFCCTGGG GTGGAACAGT AAAGACAGTG CCACCAACAA CTGCACAGAA CCCTGGGATG GAACCACGAA TGAAAGCTGC TGC=IGTGA AGTGTCTCTT TGAGAATGTG GTCCCCATGA GCTACATGGT ATAMTCAAT 'FTrGGGT GTGTTrCTGCC CCCACTGCTI ATAATGCTGG TGATCTACAT TAAGATCTIC CTGGTGGCCT GCAGGCAGCT TCAGCGCACT GAGCTGATGG ACCACTCGAG GACCACCCTC CAGCGGGAGA TCCATGCAGC CAAGTCACTG GCCATGAUIG TGGGGNF1T TGCCCTGTGC TGGTTACCTG TGCATGCTGT TAACTGTGTC ACTCTI=CC AGCCAGCTCA GGGTAAAAAT AAGCCCAAGT GGGCAATGAA TATGGCCA'Fr CFrCTGTCAC ATGCCAATTIC AG TrGTCAAT CCCATrGTCT ATGCTTACCG GAACCGAGAC T7CCGCTACA CTITCACAA AATTATCTCC AGGTATC1TC TCTGCCAAGC AGATGTCAAG AGTGGGAATG GTCAGGCTGG GGTACAGCCT GCTCTCGGTG TGGGCCTATG ATCTAGGCTC TCGCCrCITC CAGGAGAAGA TACAAATCCA CAAGAAACAA AGAGGACACG GCTGGTITC ATTGTGAAAG ATAGCTACAC CTCACAAGGA AATGGACTGC CTCTCTGAG CACTTrCCCTG GAGCTACCAC GTATCTAGCT AATATGTATG TGTCAGTAGT AGGCTCCAAG GATTGACAAA TATATI7rATG ATCTATITCAG CTGCTITAC TGTGTGGAT7 ATGCCAACAG CT7GAATGGA 'T7CTAACAGA CTCTITGT7 M~AAAAGTC TGCCTGM~ ATGGTGGAAA AT7ACTGAAA CTAT1TACT GTGAAACAGT GTGAACTATT ATAATGCAAA TAC'IrIAA CTrAGAGGCA ATGGAAAAAT AAAAGTTGAC TGTACTAAAA ATG GAA'FrCCCAG ATGGGCAGAG GTGGCTGGGC TGGTGACCCT AAGTGTGTCT CCTGCCITA T-rCTCTCTAG TGGGYFTATTC TrCATGTGG TATCTI'GCCT ACAGGATGCT GTGTTTGGAC ACAAACCCCT TTC=TGGT7 TCTCTGACCC AGCTGAGATG GACTGATICC AAAAGAACTC ACCTATGTAC TGGGGTAGGG GAGGGAGGGT TTGCAGT AT1TAACTAA GGT7CAAAGA GTGCTATATA GTGAGAAAGG CTTCTITT TF1FFITIT TITITGGCA GAGTGCTGCC TCCTAGAAAT 'rT7CT=GGT AACCC TCTGAAGCAC AGATAAAGAA AACAA'ITACA GTAGAAACAT 7rATGAGGGA CACA'FGGAG GCCGATGAAG CTITCAAGT TCCAGCAGTG CAGGGATGTG GGCAGAACTG ACATrGGAAA ATACTAGAAT GATGGAAAT7 CAGTTGGAGA GGACTGCCCT 'IIAATGTC TGGGGAGTCT GCTCAGGGAG AAATGACAAG TCTGGCGGGG ACAAGTATGG GATI17GGTAA GACTTGGATC AA=TGGGAT ACAGGGTGGG GGTCGGGAGT GGAATCAATG AATGATGCCA GAGCAGATCA ACTAACAAGA GGACCCTGAT GAGCCCCAGG CAGAGGCGTC TCCCTTATGC CCCACTCTGA AGTG1TGT7 AGTAAACACC AGAACGCCAT TGTrGTrACT GCTGAATIT AF1TGGGCT GTACATA'IT AGATGCTTAA GGTAAAAATG ATAAAGCCCT CAAGCCACTG TGTGGG=FG GGTCCAAGTG TTCCTTCTG CTGCCTCTCT AACACGCCTG GTrAAAATAA TCC='~GGA TGGTGCTGAG AAGCACCTGA ACCAAGTGGG TCCCCAAATA ACAATGGCGT GCAAGTGTCTr GGT7CCCAGA AGT7GGTGAC TAGGTAAGCA GCITCAGGGA GAGGGGGCTG ATTCCCAGAC AGTCGCCTGT TCCTGCGGGG ATGGGGCTGA GGCTTGGGGA ATGTGGGCAG GAGGATATGC CATTFGATTC TGTTGCACAC GT7CFTMCC CY=1TCTG TATGTCTGGT CATTCTGCTA T[CTGTCG7F CCTCACATAG GT7GGACATr GGCCGGCTGC CAGCATAAGT GCCAGTGTGA T=rGCTAGG TGTGAGCTGA GAAAGAGAGG TGGAGGCTAA GCAGGTGTGA TGCTrCTCAG AGGTGCTGAG TITIGCCCT TCTFGAGCAGG GAATC1TGC TFTATCCCTI GACCAAGGAT CTTGCTGCA AAGGCTGGGT ATCGGCTGTG CTCAGCAAAG CGTCAACTCG TGCAAGAACT TAGCAGGAAT AGTF7cTGGCT AAGGTTAGGA GGCTGCCACC AAAGTCTCTI =TTFCCT CTG=1CTCC CGTITGCCTC CTIATCATGA GATCTITPG CTAAGCTGGC AGAAAGATfG CATAGTCAGT G=TCCAGCT CTGCTCCCAC CTGATCCTGC ACTGTCCTCT GGTCCCTGAA TGAATGAACT CTGATACCCA AT=~GTCTC GAGC= ICTC TATGCCACTC ATGGCTCCTC 7FCTGCTCTT TCCATCTIT TGCTGAGAGT TCTGAGCTCT GTACT-rCCTC TrGGCCCATC TCACTCCTG AAACACCCCT GAAGAGGGTT GCTrATCTG ATGGAACTCA AAAAGCCAAA AAGCTGCAGG CAGAGGCGTr GAGGACATCT GMTGGGGAA CTAAGAGCAG CAGCAC'IIC AGATTCAGTC CATATAGAGC TGTCCTACAG CA F7CrGGAA A=TGAGGAT GTGCGGTGCA TAAAGGGGCT GGAAGTGACC CACCTGTGAT GAGCC=CrT TAAGGAGAAG GGTFECCAAG AGATCACCCC ACCAGAAAAG GGTAGGAATG AGCAAGTTGG GAATITAGA CTGTCACTGC ACATGGACCT CTGGGAAGAC GTCTGGCGAG AGCTAGGCCC ACTGGCCCTA CAGACGGATC FrGCTGGCTC ACCTGTCCCT GTGGAGGTFC CCCT7GGGAAG GCAAGATGCC CAACAACAGC ACTGCTCTGT CATrGGCCAA TGTTACCTAC ATCACCATGG AAA=IICAT TGGACTrCTGC GCCATAGTGG GCAACGTGCT GGTCATCTGC GTGGTCAAGC TGAACCCCAG CCTGCAGACC ACCACC'FFCT AMTCAT7GT CTCTCTAGCC CTGGCTGACA T[GCTGTTGG GGTGCTGGTC ATGCCTTGG CCATTGTrGT CAGCCTGGGC ATCACAATCC A=TCTACAG CTGCCTFI= ATGACTTGCC TACTG=IAT CIIACCCAC GCCTCCATCA TGTCCTTGCT GGCCATCGCT GTGGACCGAT ACTI'GCGGGT CAAGCTTACC GTCAGGTAGC CTGCGGCGTG GGGTGGGCAG CAATTGAGGC AGCTGGGAAA TGAGGCTACA AAGCCAGAGCS CTGCTGAA T 'rrATIGGA CTGTACATAT 77AGATGCIT AAGGTAAAAA TGATAAAGCC CTCAAGCCAC TGTGTGGG'FF GGGTCCAAGT GrrCC=GCT GCTGCCTCTC TAACACGCCT GGTrAAAATA ATCCC=fGG ATGGTGCTGA GAAGCACCTG AACCAAGTGG GTCCCCAAAT AACTATGGCG TGCAAGTGTC TGGTrCCCAG AAGTTGGTGA CTAGGTAAGC GACTCAGGGA GAGGGGCTGA TTCCCAGACA GTCGCCTGPT CCTGCTGGGA TGGGGCTGAG GCTrGGGGAA TGTGGGCAGG AGGATATGCC ATTGA'TCT GTlGCACACG TrC'nTCCC TTCrCGT ATGTCTGGTC A'ITCTGCTAT TCTGTCGTF7C CTCACATAGG 77GGACATTG GCCGGCTGCC AGCATAAGTG CCAGTGTGAT TIGCTAGGG TGTGAGCTGA GAAAGAGAGG TGGAGGCTAA GCAGGTGTGA TGCTrCTCAG AGGTGCTGAG 'FTI1GCCCT TCTGAGCAGG GAAT='TGC TTATCCCFF GACCAAGGAT CTIGCTCCA AAGGCTGGGT ATCGGCTGTG CTCAGCAAAG CGTCAACTCG TGCAAGAACT TAGCAGGAAT AGTrCTGGCT AAGGTTAGGA GGCTGCCACC AAAGTCT=T =IIGTTCCT CTGCTrCTCC CG'I1rGCCTC =TATCATGA GATCITr=G CTAAGCTGGC AGAAAGATrG CATAATCAGT GCTT1CCAGCT CCGCTCCCAC CTGATCCTGC ACTGTCCTCT GGTCCCTGAA TGAATGAACT CTGATACCCA ATC'IGTCTC GAGCCTICTC WO 00/09525 PCTIUS99/17712 EPI-109 21 TATGCCACTC ATGGCTCCTC TTCTGCTCTT TCCATCTTTT TGCTGAGAGT TACTGAGCTC TGTACTTCCT CTTGGCCCAT CTCACTTCCT GAAACACCCC TGAAGAGGGT TGCTTATCT7 GATGGAACTC AAAAAGCCAA AAAGCTGCAG GCAGAGGCGT TGAGGACATC TGTTTGGGGA ACTAAGAGCA GCAGCACT CAGATTCAGT CCATATAGAG CTGTCCTACA GCATTCTGGA AACTTGAGGA TGTGCGGTGC ATAAAGGGGC TGGAAGTGAC CCACCTGTGA TGAGCCCTTT CTAAGGAGAA GGGTTTCCAA GAGATCACCC CACCAGAAAA GGGTAGGAAT GAGCAAGTTG GGAATTITAG ACTGTCACTG CACATGGACC TCTGGGAAGA CGTCTGGCGA GAGCTAGGCC CACTGGCCCT ACAGACGGAT CTTGCTGGCT CACCTGTCCC TGTGGAGGTT CCCCTGGGAA GGCAAGATGC CCAACAACAG CACTGCTCTG CGAATTCGGG GGACATCTGT TTGGGGAACT AAGAGCAGCA GCACTTTCAG ATTCAGTCCA TATAGAGCTG TCCTACAGCA TTCTGGAAAC TTGAGGATGT GCGGTGCATA AACGGGCTGG AAGTGACCCA CCTGTGATGA GCCCTTTCTA AGGAGAAGGG TTTCCAAGAG ATCACCCCAC CAGAAAAGGG TAGGAATGAG CAAGTTGGGA ATTAGACT GTCACTGCAC ATGGACCTCT GGGAAGACGT CTGGCGAGAG CTAGGCCCAC TGGCCCTACA GACGGATCTT GCTGGCTCAC CTGTCCCTGT GGAGGTTCCC CTGGGAAGGC AAGATGCCCA ACAACAGCAC TGCTCTGTCA TTGGCCAATG TTACCTACAT CACCATGGAA ATTTTCATTG GACTCTGCGC CATAGTGGGC AACGTGCTGG TCATCTGCGT GGTCAAGCTG AACCCCAGCC TGCAGACCAC CACCTrCTAT TTCATTGTCT CTCTAGCCCT GGCTGACATT GCTGTTGGGG TGCTGGTCAT GCCTTTGGCC ATfGTTGTCA GCCTGGGCAT CACAATCCAC TrCTACAGCT GCCTTAT GACTTGCCTA CTGCTTATCT TTACCCACGC CTCCATCATG TCCTTGCTGG CCATCGCTGT GGACCGATAC TTGCGGGTCA AGCTTACCGT CAGATACAAG AGGGTCACCA CTCACAGAAG AATATGGCTG GCCCTGGGCC TTTGCTGGCT GGTGTCATTC CTGGTGGGAT TGACCCCCAT GTTTGGCTGG AACATGAAAC TGACCTCAGA GTACCACAGA AATGTCACCT TCCTTCATG CCAATITGTT TCCGTCATGA GGATGGACTA CATGGTATAC TTCAGCTTCC TCACCTGGAT TTTCATCCCC CTGGTTGTCA TGTGCGCCAT CTATCTTGAC ATCFTTACA TCATTCGGAA CAAACTCAGT CTGAACTTAT CTAACTCCAA AGAGACAGGT GCATTTTATG GACGGGAGTT CAAGACGGCT AAGTCCTTGT TTCTGGTTCT TTTCTTGTTT GCTCTGTCAT GGCTGCCTTT ATCTCTCATC AACTGCATCA TCTACTTTAA TGGTGAGGTA CCACAGCTTG TGCTGTACAT GGGCATCCTG CTGTCCCATG CCAACTCCAT GATGAACCCT ATCGTCTATG CCTATAAAAT AAAGAAGTTC AAGGAAACCT ACCIT11GAT CCTCAAAGCC TGTGTGGTCT GCCATCCCTC TGATTCTTTG GACACAAGCA TTGAGAAGAA TTCTGAGTAG TTATCCATCA GAGATGACTC TGTCTCATTG ACCTTCAGAT TCCCCATCAA CAAACACTTG AGGGCCTGTA TGCCTGGGCC AAGGGATT TACATCCTrG ATTACTTCCA CTGAGGTGGG AGCATCTCCA GTGCTCCCCA ATTATATCTC CCCCACTCCA CTACTCTCTT CCTCCACTTC ATITTCCTT TGTCCTCT CTCTAATTCA GTGTTTGGA GGCCTGACTT GGGGACAACG TATTATTGAT ATTATTGTCT G'-11-CCTrC TTCCCAATAG AAGAATAAGT CATGGAGCCT GAAGGGTGCC TAGTTGACTT ACTGACAAAA GGCTCTAGTT GGGCTGAACA TGTGTGTGGT GGTGACTCAT TTCCATGCCA TTGTGGAATT GAGCAGAGAA CCTGCTCTCG GAGGATGCCT AGGAGATGTT GGGAACAGAA GAAATAAACT GAGTTTAAGG GGGACTTAAA CTGCTGAATT C AAATGATAGA CCGTCAATAA TTTGTFAAAT GCUITCTAAA ATGAATGCTT TAAGCCGGGT GCAGTGCCTC ACATCTGTAA TCCCAGCACT TTGGAGCCGA GCGGGTGGAT TGTGTGAGGT CAGGAGTTCG AGACCAACCT GGCCAACATG GCAAAACCTC ACTCTCTACC AAAAATACAA AAATTAGCCA GGCATGGTGG CAGGCACCTG TGATCCCAGC TACTCAGGAG GCTGAGACAG GAGAATCGCT TGAACCCGGG AGGCAAGGTT GCAGTGAGCC AAGATTACGC CATrGTACTC CAGCCTGGGT GACAGAGAGA GACTCCGTCT CAAAAAAAAA AAAAAAAAAA AAAAAATTAC GCTTCAAACA CATGATCTCT CACCACTGTTr GAATTTCTT TCTATGAGCC CAGGAGGGCC TCTCAGAGAG GAAAGCTCCT AGGTCTTCCT TTCCCTCTGC AAACTCCCTG CCTTGAAGGT TCAGAAGGAC TGTGCGTGCT CGTTGCATCC TTGCAAGTG TCCAAACCCT GATCCCAGCT GTGCTTAGGG GTTCCTGCAA ACCTTTTCCA GGTGTFAATT ACCTCCCACT TCATCCTG TTTACCAACT CAGCITil G TTTTAGTGTG TTTGAATTCC CTGAACTGAC CGTTGTCTGA TCTCCACCTC CCAACTGAAT TAGGGGAGCT GGGCTTCTGG AAACCCAGGT GCCGGGTGTT GCAGAGTGGC TGAAAGCTGG GATGTGGCAG ATCCGTGGCT ACATTCATGC ACACACACAC ACCCACATAC CCACACATGC ACACACACAC ACACACCCGC ACTCACACAC TTGGACATGC ATAGACCACA GCTTTCCACA CCCTTCCTAG ACAGGGGTCA CTTGGTATCC TGGAGAGAGT GTGAAGTCCT GGAATGGAAA GAGGGGGGAT TAAGCCCCAC CTCTAGCCAT GGGACTGAGA CAAGTCACCA CCAACCCATC TGCGCCTTGT TTACCTCCTC TGTGAGGCAA GCACAGAGCC CATGCCTGCC CCCCTGGATG GGAGTGATGT GAAACTTGAA GGGCGGTCAG AGCAAGGGTC GGGAATGGAA GGCCCTTGGG AAAAAAGGCC CTTCAACTA GGGGCACAGA GGAGGCCCTG GGCTGAGAAC TTGACAGCAC CTTGTAAT'TG GTAAGCCAAG CCCGAAGGGA CTGGAAATAC TCAGATGTGT CTGTCTCCCT TATTAGGrC AAAGTCCCTC AAGACCCTGT CTCCATCACA GTGCTCCAGT CCAGACCCCT CCTCTGAGCT CCAGACCCTG CTGGACCCAA CCAGCCCTAT GGGGTCGCAT CCCCACCTGC CTGGAATTCT CCAAAGAACC TCCCCTTAA CAGTTCCAGC CTTTAACAGT TCCAGTCTAA ACACATGACC TTCTCCTCT AAATCAGCCC CCCATCTCTG CCTTGCAGG AGATGGAAGC CATGACACCT GCCTCGCCCC TGTCCTCACC CCATCCATGT CCAATCAAGC ACTAGGCATG TCAGGTrTAC CCTCTAAACT CCTCTGGAAT CCAGTCTCTC AGTCTCCATC ATCCCAGGTC GAAGCTAATG GGCTAACTGG TCCTTGCTTC CACTCTACCC CCACTGCAGT CCTGACTrCC TGAGCAGCAG CCAGGGCCTA ATCGATATTC ACACCAAGCG CCAACCTGAC TGAGATATCC TCCTGCACCA TCATCCCTCC ACCCTGTTTA GTTCTGCTCA CCCTCAGTGT TCTCATCAAT AATCCACTCC CCTCACAGGC GCGTTGGGA CCCCATGTTC TATGCTCTCA CAGGACCTTT TGCTTGATTT TTCACTGTAC TTAGGTCAGT TTGCAGTTAT TAAGTGACTG AGCAATGTCT GGCTTCTCCA GTAGACTGTC AGCTCCTAGC CATTGTATAC CTAGCACCGC TGTGTGGGAG CACGTGACAA ACGTCCAGTG AGTCAGGGAC TCAGCAGTCT CCATTTCTCC GCCCTGCTGG AGAATGCGTG TATTTGGCAA TCCCCAGCCC CTGTGCCATC TAACCATCTT TTCTTCTCTG TTCAGCCCAG GTGTGGCCTC ACTCACATCC CACTCTGAGT CCAAATGTTC TCTCCCTGGA AGATATCAAT GTTTCTGTCT GTTCGTGAGG ACTCCGTGCC CACCACGGCC TCTTTCAGGT GAGTCAAAGG GATTCCTCAG TTCACTAGTT AGGGGAGGTG GGCAGACACC CTGGAGAACT CCCTGGAAAG CTCAACTCTC ATGCCCCGGA CAACAGTTGA AGGAACCATG GTGATGTTAA GCCCAAAGAC AAAACCTCTC AGGTGTCCAA GTCCCTGTTG GAATCTTGGG AGCAGAGGGA ATG'TCTGTG GTCTAGAGGA AGAGGGGCTC AGGGAGGAGA AGGGCACATT CCTGGTTGTT ATATGTTCT ATCTATCCCA WO 00/09525 PCT/US99/17712 EPI-109 22 GATGAACTTG GAAGTGAAGG GAAGAGAGTr AAACATTAAA GTAAATACCC AGTGGATCAG ACAGCAATGT GCCAGATTGC CTTGGAAACA AAATATCTCC AACACATGGC TGACATTTGG TGGGAGATCA GAACACCCTA AAGAGAGAAT TTAAGGGGAG GGGGAGGAGG ACCTGAGCCA GAGTAGAAGC AGAGGATAGG GAGATCTGTT CTTGGGGACA GCAnTGCAA GAAACAAGGC TGAGGGGTCC ACTCCAACCT CTCCACCCTG CTGCAGGTGC TGCCTATGAT GAAGATGAGC AGATGGCCAT CTCAGCTGGG GCCACAGTGC ACTGGACCTA TAGTTTCCAA TTCCGCACTC AGCAGGCATC TTrCTGATGA TCCGATGGCT TCTCAGAGCC AGGGATGGGC CAGGATCCAT CCCCTTGGCT ACTGTCTTGC TGAGAAATTT ATAAGCAGCA TCTGGTGCTA TACTTGGTC TCTAGTGAGT TAGCTCATGA AAGATGATAG ACTCTCCAAG CCAGGGGTAT GCAGGAAATG GGTTTTCTGT AGCTACAGAA ATGGGGTTGA GGGTTGGACC AAGGGACTAC CCAGGGGAAG TCTTACCTTC AGAGGACTCT GGAAAGGAGG CTGCAAGTIT TCATGGGTCA AGAATTCAGA GCCCAGTAGA GACAGCTTAT CTCTGTTCCA AGATGTCTGG GGCCTTGGTT GGAAGATTCA AAGGCTAGGA AACCAGGAGC CACCAAAAGC GTAACTGGGG CCAGAGGATC CACTTCAAG GTGGCAAGTT GGTTCCCCCC ATGTGGCTGC TTGAGTATCC TCACATGGCG GCTCACATCC TTCCAAGTAA GCAATGCAAA AGGCCAAGAA AGATGCTGCA AAGATGTrAT GACCTAGCCT CAGAAATCAC ACACCATCCC TGCCACCATT AGTAAGAAGT CCAGCCCACG TCCAGGAGAA GAGGAAGCAG ATTCCTCCTr TTGAAATGAA GAATATCAAG TAATTCGGGG GGCATATGAA AGCCACCACA CACCACAGGG ATCTIT11AG AGCATACTTC TTATACCATC ACTGTAGTTC CTTAAGACTC AGGGGCAAAG CCTCACTTCC TTAGCACCCA GTGAAGACCA CGCTTACTCC CTCACTCAAC CTCTTGCTAC TTCCCACCTC TCCTGTCCAA CATCTAGTGT CACTTCCAG AACATACCAA CAGCTTCCCC AGTTCTGTGC CTCTGCTCAG GCTGTTCCCC CTGCCTGGTC CACTTGTCCT CCTTCTTGTC CGGTCAAAAT GCTrCTTATC CTTCAAGACC CAGCTCTAGA GTCACCTCCA ACCCCTTACC CACCAGCCCC CTCTCCAAGT CTGTGTCCCA CAACCCCCCT GCTCCCTCCA GGGCACCCTC CACCCTCTGG GCCACAGTTG TCAGGAGTCA GGCAGGGCAG GGGCCGGGTG GTGTCTTCTT TGTGTTCTTG CACTCAGGGC AGAGCTCAGC ACAGAGCAGA CGCTCAAAAA ACATTTAAAG GATAGAAGCA TTGATTTGTG GGTCCCCCAG TCTGGCTCCA GGATGCCAGC CAGCTGCTCC TAGAAGCAAA CGGACTTC CTGGGAAATC CCAGAGGTGA TGATCAGTAA TCTCTCCCGT GACTCGTAGT TCAGCTCTTC CTCCATGAGC CTGACTATCA GTGGACCTTC CAGAAAGAGC CCCTTTTCCT TCTCTCACCC ACAGCACAGG GCACTGGGAA AATGCCCAAT GAGTCCTGCC TCTGGGTTGT GCITGGACT TTTCAGTGTG TCTCGCATCC ACTCTTCAAC TTGAATGTTG CAACAGCCAT GAAAAAAGAA ATGCAAAGCG ATTCAGGATG AGAGCAATAC CCTACTCCAA AGAAGGCAAC ATAGAAGCTC AGAGAGATCA AGCAATTTGC CCAAGACCAC ACAGCTAGGA GTGGAACTCA TGGCTGTCCA AGCCCCATGC CTCTGCTGAA GGTAGAGATG AATTACAGCA ACAAGTCTAG AAAGGTGCCT GCCCTATGGT CTGTGAGTCT TGCCTAAGAA TGAAAGAGGA GCCAGTGGGT TAAAGATGAG GTCACCAACA ACGGTGGTGT TGGAGTTTAC CACTGATAAT AAGGGTGCAA AATGTAAATT ACTAATG'TTT ATTGAGCCTA GTGCAGTGCG TGGGGCATTr TGCACATTGT CTCTGATCCC TATGACAACC CTGAGAGGTA GTGGTTAA CTGCCATGTT ACAGGTGAGG TCATTGTGGT TCAAGGACGT TAAGTAACTT CCCCAGCGTG ACACGGCTTA TAAGTAAGGC AGCCAGGATG TGAACCCAGT AGGACTATCT GGCTGCAAAG TCCCCACCCC CCTCGCCATC TGTATCCTCC AATCACTTCA GTGCTITGCT GCATAGAAGG TAACGGAAAT CACGATGCCA CAGACTGTCC AGGAAGACAG AAACTAGGCA GATGGGCTGG CCATGGTCTC CAAGCCAGAC TGGAATCTCC AGGTCTGGAA TGATATCATT TTCTCITIT AATAAATTAA CTCACCCACC ACACGGCTT GAGAGGCTCA AAGTTGACCA ACTCCCTTGG GAGGGCCCCG GTTGATAAGG AAGGAACGTG AATCCTCCCA TCACGGAAGC T'rCAAGGAGG TCAAGGGTCC AACACTTGAG A'TTGTTAGTG CTGTTGGTGG ATACTGGCCA AGGAAATATC CCAGTGGAGC CTCGAGATGA AGAACATGAG GCCCCCGTTT AGAACCAAGG ATCAGAGGGG GCTCTGTAAG ACCCAGGGGA GTCAGGTGCA CTGGAGCGCG GGCATGCAGA AAACAGCCTG AGCTCCACCT CGGCTTCTCC TTGTCCTGGC TGGTTGTCCT TAACCCCTGT CTCCTTCTGG ACCAG'I ii GTCCTTCCCT TGTGACCGCT GAGGGGTAAC AGCCTCTTTC CACTTCTTT CAGCGCCGAC ATGCTCAATG TCACCTTGCA AGGGCCCACT CTTAACGGGA CCTTTGCCCA GAGCAAATGC CCCCAAGTGG AGTGGCTGGG CTGGCTCAAC ACCATCCAGC CCCCCTTCCT CTGGGTGCTG TTCGTGCTGG CCACCCTAGA GAACATCTTT GTCCTCAGCG TC7TCTGCCT GCACAAGAGC AGCTGCACGG TGGCAGAGAT CTACCTGGGG AACCTGGCCG CAGCAGACCT GATCCTGGCC TGCGGGCTGC CCTTCTGGGC CATCACCATC TCCAACAACT TCGACTGGCT CTTTGGGGAG ACGCTCTGCC GCGTGGTGAA TGCCATTATC TCCATGAACC TGTACAGCAG CATCTGTTTC CTGATGCTGG TGAGCATCGA CCGCTACCTG GCCCTGGTGA AAACCATGTC CATGGGCCGG ATGCGCGGCG TGCGCTGGGC CAAGCTCTAC AGCTTGGTGA TCTGGGGGTG TACGCTGCTC CTGAGCTCAC CCATGCTGGT GTTCCGGACC ATGAAGGAGT ACAGCGATGA GGGCCACAAC GTCACCGCTT GTGTCATCAG CTACCCATCC CTCATCTGGG AAGTGTTCAC CAACATGCTC CTGAATGTCG TGGGCTTCCT GCTGCCCCTG AGTGTCATCA CCTTCTGCAC GATGCAGATC ATGCAGGTGC TGCGGAACAA CGAGATGCAG AAGTTCAAGG AGATCCAGAC GGAGAGGAGG GCCACGGTGC TAGTCCTGGT TGTGCTGCTG CTATTCATCA TCTGCTGGCT GCCCTTCCAG ATCAGCACCT TCCTGGATAC GCTGCATCGC CTCGGCATCC TCTCCAGCTG CCAGGACGAG CGCATCATCG ATGTAATCAC ACAGATCGCC TCCTTCATGG CCTACAGCAA CAGCTGCCTC AACCCACTGG TGTACGTGAT CGTGGGCAAG CGCTTCCGAA AGAAGTCTTG GGAGGTGTAC CAGGGAGTGT GCCAGAAAGG GGGCTGCAGG TCAGAACCCA TTCAGATGGA GAACTCCATG GGCACACTGC GGACCTCCAT CTCCGTGGAA CGCCAGATTC ACAAACTGCA GGACTGGGCA GGGAGCAGAC AGTGAGCAAA CGCCAGCAGG GCTGCTGTGA AT'TTGTGTAA GGATTGAGGG ACAGTTGCTT TTCAGCATGG GCCCAGGAAT GCCAAGGAGA CATCTATGCA CGACCTTGGG AAATGAGTTG ATGTCTCCGG TAAAACACCG GAGACTAATr CCTGCCCTGC CCAATTTTGC AGGGAGCATG GCTGTGAGGA TGGGGTGAAC TCACGCACAG CCAAGGACTC CAAAATCACA ACAGCATTAC TGTTCTTATf TGCTGCCACA CCTGAGCCAG CCTGCTCCTT CCCAGGAGTG GAGGAGGCCT GGGGGCAGGG AGAGGAGTGA CTGAGCTrCC CTCCCGTGTG TTCTCCGTCC CTGCCCCAGC AAGACAACTT AGATCTCCAG GAGAACTGCC ATCCAGCTT GGTGCAATGG CTGAGTGCAC AAGTGAGTTG TTGCCCTGGG TTCTTTAAT CTATTCAGCT AGAACTITGA AGGACAATT CTT GCATTAA TAAAGGTTAA GCCCTGAGGG GTCCCTGATA ACAACCTGGA GACCAGGATT TrATGGCTCC CCTCACTGAT GGACAAGGAG GTCTGTGCCA AAGAAGAATC CAATAAGCAC ATATTGAGCA CTTGCTGTAT ATGCAGTATT GAGCACTGTA GGCAAGAGGG AAGAAAGAGA AGGAGCCATC WO 00/09525 PCT/US99/1 7712 EPI-109 23 TCCATCTTGA AGGAACTCAA AGACTCAAGT GGGAACGACT GGGCACTGCC ACCACCAGAA AGCTGT .rCGA TGAGACGGTC GAGCAGGGTG CTGTGGGTGA TATGGACAGC AGAAGGGGGA GCCAGG FrCC AGCTCACCAA TACTATFGCA CACCACC2TGT CCTGCCTC GCCC'T7CAAA GATGAGCTGT TCCCGCCGCC ACTCCAGCTC TGGCT7CTGG GCTCCGAGGA GGGGTGGGGA CGGTGGTGAC GGTGGGGACA TCAGGCTGCC CCGCAGTACC AGGGAGCGAC TGAAGTGCCC ATGCCGCTIG CTCCGGAGAA GGTGGGTGCC GGGCAGGGGC TGCTCCAGCC GCCTCACCTC TGCTGGGAGG ACAAACTGTC CCAGCACAGA GGGAGGGAGG GAGGGCAGGC AGCGGGGAGA AGTT7CCCTG TGGTCGTGGG GAGIT GAGCTCrrCA ATA=IIAGT GAAAGCTATA GATGAGGCTC CATAGGGGAT AAAGCACAGA CACACC'fT CAGAGGGCTT GTGGACTCTG GGCAGCCTGT CCATAGACCT CTGTCCCCAA CTGGCAAGTC AGGAAACTCC AGATTAAGGA GCCCCAATGT GGTrGAACAG CCAGGTGCAC AGATGAGTCA ACCACACAGC CAGGCCAGGG AGGGCC=CA CTCAAGAGCC TACAGCCAGT TCACAGCCAA GCCAGGGCTA GCGCCAGGCC ACCCATAAAC TGATCTGAGA CTCTGT1TCC CTGTCTCCAT GATGATGGGA TCAGGCTrGA T7GCTGG'Tr GTAGGC'ITGT TATGAATCAA GTCACAGGGA AGAGGAGCTG ATGGGCTGGG GGGACGTCCT CTGGCCCTCC TGTCTCTrCC CCAGATCCAC TGGGCCCACT CTTATCTG'FF CTCTrCTGAA GGAAGGGTTF TAAGGC17CA AAAAAAAATG TITGAAAGT CCCTGCCCTI7 TCCAGCTCCT ACCGTCTCAG CCCTGGGAGT GTAAAGTGCT GCAGATAGT[ AGTAAGTCT7 TGAGCAAAAC TGAGAAAGCC AGCCTGAGCC flGACATGGG AGAAACCTCC GCCATACATC TCCGAAGAAA CGGCCGCGTG TCTCAGGGGA GCGCAAACAC CCGTACCCAG GAAACAGGAC AGCTTCTGCC ACTGTCGCCC TTGGGAGCCG TACGTGGCAT GACAAAGAAA TCCCAGGACT CCGCCTGCCC ACCTGGCCAC CCTCTGTTA CAC=TCCGC GTAAACGCCC ACTGn7IACA TCCAAAACTC AGACACAAAA TAACCACCTC AAGAAGATAA ATAATGATAA GAAATAAATG TrACGCGAGG CAAAnTr CACATGGGGC TTCCCAGGCC ACTIGTGGT CAGCCGGGAG GGACGTT1T GCCGTCCCAC GACTCCAACG GGCAGCCGGG CCTACGCAAA CATGGAAATC TrCCAAGAGC CTCCCTGGCC CCCAGGGCTC AGAGGGTGGC AGAGCGGAGA GCGAAGGTGG CCGCAGCCT CCCGGCCCCA CAGCCAGCCT GGCTCCAGCT GGGCAGGAGT GCAGAGCTCA GCTGGAGGCG AGGGGGAAGT GCCCAGGAGG CTGATGACAT CACTACCCAG CCCTI'CAAAG ATGAGCTG~r CCCGCCGCCA CTCCAGCTCT GGCTT, CTGGG CTCCGAGGAG GGGTGGGGAC GGTGGTGACG GTGGGGACAT CAGGCTGCCC CGCAGTACCA GGGAGCGACT GAAGTGCCCA TGCCGCT-rGC TCCGGAGAAG GTGGGTGCCG GGCAGGGGCT GCTCCAGCCG CCTCACCTCT GCTGGGAGGA CAAACTGTCC CAGCACAGAG GGAGGGAGGG AGGGCAGGCA GCGGGGAGAA GTTTCCCTGT GGTCGTGGGG AG'TGGGAAA AGTTCCCTC CTTCCGGAGG GAGG CAGATTCACA AACTGCAGGA CTGGGCAGGG AGCAGACAGT GAGCAAACGC CAGCAGGGCT GCTGTGAATr TGTGTAAGGA TTGAGGGACA GTTGCT=TC AGCATGGGCC CAGGAATGCC AAGGAGACAT CTATGCACGA CCITGGGAAA TGAGTTGATG TCTCCGGTAA AACACCGGAG ACTAATrCCT GCCCTGCCCA ATITGCAGG GAGCATGGCT GTGAGGATGG GGTGAACTCA CGCACAGCCA AGGACTCCAA AATCACAACA GCATrACTGT TCTrA1GC TGCCACACCT GAGCCAGCCT GCTCC~rCCC AGGAGTGGAG GAGGCCTGGG GGGAGGGAGA GGAGTGACTG AGCTITCCCTC CCGTGTG FTC TCCGTCCCTG CCCCAGCAAG ACAACTTAGA TCTCCAGGAG AACTGCCATC CAG=1IGGT GCAATGGCTG AGTGCACAAG TGAG'rG'T7G CCCTGGGTT =1TAATCTA T7CAGCTAGA AC'TIGAAGG ACAAMTT GCATTAATAA AGGTTAAGCC CTGAGGGGTC CCTGATAACA ACCTGGAGAC CAGGA=IIA TGGCTCCCCT CACTGATGGA CAAGGAGGTC TGTGCCAAAG AAGAATCCAA TAAGCACATA 17-GAGCACTT GCTGTATATG CAGTAT7GAG CACTGTAGGC AAGACCCAAG AAAGAGAAGG AGCCATCTCC AT=TGAAGG AACTCAAAGA CTCAAGTGGG AACGACTGGG CACTGCCACC ACCAGAAAGC TGTTCGACGA GACGGTCGAG CAGGGTGCTG TGGGTGATAT GGACAGCAGA AGGGGGAGAC CAAGGTrCCA GCTCAACCAA TAACTAITGC ACAACCACCT GTCCCTGCCT CAGTTCCC'Fr TTATGTAACA TGAAGTCGT GTGAGGGTTA AAGGCAGTAA CAGGTATAAA GTACTIAGAA AAGCAAAGGG TGCTACGTAC ATGTGAGGCA TCATACGCA GACGTAACTG GGATATGTFI7 ACTATAAGGA AAAGACACTG AGGTCTAGAA ATAGCTCCGT GGAGCAGAAT CAGTATTGGG AGCCGGTGGC GGTGTGAAGC ACCAGTGTCT GGCACACAGT AGGTGCTCAT TGGCTCCC= CCACCTGTCA FTCCCACCAC CCTGAGGCCC CAACCGCCAC ACACACAGGA GCATT GGAG AGAAGGCCAT GTCICAAAG TCTGAT1T7GT GATGAGGCAG AGGAAGATAT TrCTAATCGG TCTTGCCCAG AGGATCACAG TGCTGAGACC CCCCACCACC AGCCGGTACC TGGGAAGGGG GAGAGTGCAG GCCTGCTCAG GGACTG'I17CC TGTCTCAGCA ACCAAGGGAT TG FFCCTGTC AATCAATGGT TTATrGGAAG GTGGCCCAGT ATGAGCCCTA GAAGAGTGTG AAAAGGAATG GCAATGGTGT TCACCATCGG CAGTGCCAGG GCAGCACTCA T7CACTITGAT AAATGAATAT 'FrATrAGCTG G'ITGGAGAGC TAGA A=cGG AGAGCTAGAA CCTGGAGAAC TAGAACCTGG AGGGCTAGAA CCTGGAGAGG CTAGAACCAA GAAGGGCTAG AACCTGGAGG GGCTAGAACC TAGAGAAGCT AAAACCTGAG CTAGAAGCTG GAGGACTAGA ACCTGGAGGG CTGGAATCTG AAGGGCTAGA ACCTGGAGGG CTGGAATCTG GAGAGCTAGA ACCTGGAGGG CTAGAACCTG GAGGGCTAGA ACCTAGAAGG GCTAGAACCT GGAGGGCTGG AATCTGGAGA GCTAGAACCT GGAGGGCTAG AACCTGGAGG GCTAGAACCT AGAAGGGCTA GAACCTGGAG GGCTAGAACC TGGCAGGTFA GAACCTAGAA GGGCTAGAAC CTGGAGAGCC AGAACCTGGA GGGCTAGAAC CTGGAAGGGC TAGAACCTGT AGAGCTAGAA CATGGAGAGC TAGAACCCGG CAGGCTAGAA CCTGGCAAGC TAGAACCTGG AGGGAATGAA CCTGGAGGGC TAGAACCTGG AGAATGAGAA AAATI]ACAT GGCAAAGAGC CCATAAATCC TGACCAATCC AACTCTGAAT 'ITAAAGCAA AAGCGTGAAA AAAAAGAFI7C CCTCCTACC CCCAACCCAC TCTITITCC CACCACCCAC TCTCCTCTGC CTCAGTAAGT ATCTGGAGGA AGAAAACAGG TGAAAGAAGA AGTAAAAACC ATTTAGTATFT AGTATTAGAA TGAAGTCAAA CTGTGCCACA CATGGTGAAT GAAAAAAAAA AAAAAGAGGC TGTG=IIGT CACACAGGGC AGTCATI'CAG CACCAGAGCA CGTGATGGTC TGAGACTCTC 'FIAGGAGCAG AGCTCTGCCG CAATGGCCAT GTGGGGATCC ACACCTGGTC TGAGGGGCAA CTGAGTCTGC GGGAGAAGAG CGGCCCTATG CATGGTGTAG ATGCCCTGAT AAAGAACATC TGTCCTGTGA AAGACTCAAT GAGCrGTTAT G'FrGTAAACA GGAAGCAT17 CACATCCAAA CGAGAAAATC ATGTAAACAT GTGTC1TC TGTAGAGCAT AATAAATGGA TGAGG'TV= GCAAAAAAAA AAAAAAAAA AAATGATAGA CCGTCAATAA TIGTfAAAT GCFT'ITAAA ATGAATGC'= TAAGCCGGGT GCAGTGCCTC ACATCTGTAA TCCCAGCACT TTGGAGCCGA GCGGGTGGAT TGTGTGAGGT CAGGAGTrCG AGACCAACCT GGCCAACATG GCAAAACCTC ACTCTCrACC AAAAATACAA AAA'AGCCA GGCATGGTGG WO 00/09525 PCTIUS99/1 7712 EPI-109 24 CAGGCACCTG TGATCCCAGC TACTCAGGAG GCTGAGACAG GAGAATCGCT TGAACCCGGG AGGCAAGG FT GCAGTGAGCC AAGA'FrACGC CA TGTACTC CAGCCTGGGT GACAGAGAGA GACTCCGTCT CAAAAAAAAA AAAAAAAAAA AAAAAAITAC GCT7CAAACA CATGATCTCT CACCACTG17 GAA=I1CTT TCTATGAGCC CAGGAGGGCC TCTCAGAGAG GAAAGCTCCT AGGTCTrCCTr TTCCCTCTGC AAACTCCCTG CCrTGAAGGT TCAGAAGGAC TGTGCGTGCT CGTGCATCC TGCAAGTG TCCAAACCCT GATCCCAGCT GTGUCTAGGG GTrCCTrGCAA ACCT1TCCA GGTGTrAA'rr ACCTCCCACT TCA ITCCTG TrACCAACT CAGCTIT=G TITTAGTGTG MTGAATTCC CTGAACTGAC CGTTGTCTGA TCTCCACCTC CCAACTGAAT TAGGGGAGCT GGGCTCTGG AAACCCAGGT GCCGGGTGTF GCAGAGTGGC TGAAAGCTGG GATGTGGCAG ATCCGTGGCT ACATTCATGC ACACACACAC ACCCACATAC CCACACATGC ACACACACAC ACACACCCGC ACTCACACAC TTFGGACATGC ATAGACCACA GC'TCCACA CC=TCCTAG ACAGGGGTCA CTGGTATCC TGGAGAGAGT GTGAAGTCCT GGAATGGAAA GAGGGGGGAT TAAGCCCCAC CTCTAGCCAT GGGACTGAGA CAAGTCACCA CCAACCCATC TGCGCCTGT TTACCTCCTC TGTGAGGCAA GCACAGAGCC CATGCCTGCC CCCCTGGATG GGAGTGATGT GAAACTI'GAA GGGCGGTCAG AGCAAGGGTC GGGAATGGAA GGCCCT7GGG AAAAAAGGCC CI=CAACTA GGGGCACAGA GGAGGCCCTG GGCTGAGAAC TTGACAGCAC CTTGTAAFITG GTAAGCCAAG CCCGAAGGGA CTGGAAATAC TCAGATGTGT CTGTCTCCCT TA TAGGTTC AAAGTCCCTC AAGACCCTGT CTCCATCACA GTGCTCCAGT CCAGACCCCT CCTCTGAGCT CCAGACCCTG CTGGACCCAA CCAGCCCTAT GGGGTCGCAT CCCCACCTGC CTGGAATTCT CCAAAGAACC TCCCCT=AA CAGT-TCCAGC CF-rTAACAGT TCCAGTCTAA ACACATGACC TTrCTCCTCT AAATCAGCCC CCCATCTCTG CCI=GCAGG AGATGGAAGC CATGACACCT GCCTCGCCCC TGTCCTCACC CCATCCATGT CCAATCAAGC ACTAGGCATG TCAGGTITAC CCTCTAAACT CCTCTGGAAT CCAGTCTCTC AGTCTCCATC ATCCCAGGTC GAAGCTAATG GGCTAACTGG TCCT[GCT1TC CACTCTACCC CCACTGCAGT CCTGACTCC TGAGCAGCAG CCAGGGCCTA ATCGATA~rC ACACCAAGCG CCAACCTGAC TGAGATATCC TCCTGCACCA TCATCCCTCC ACCCTGITIA GT[CTGCTCA CCCTCAGTGT TCTCATCAAT AATCCACTCC CCTCACAGGC GCG'ITTGGGA CCCCATGTTC TATGCTCTCA CAGGACCFI TGC7GATT TFICACTGTAC TTAGGTCAGT TI'GCAGflAT TAAGTGACTG AGCAATGTCT GGCYCTCCA GTAGACTGTC AGCTCCTAGC CATFGTATAC CTAGCACCGC TGTGTGGGAG CACGTGACAA ACGTCCAGTG AGTCAGGGAC TCAGCAGTCT CCA=flCTCC GCCCTGCTGG AGAATGCGTG TA=~GGCAA TCCCCAGCCC CTGTGCCATC TAACCATCT rC7CTG TTCAGCCCAG GTGTGGCCTC ACTCACATCC CACTCTGAGT CCAAATGflC TCTCCCTGGA AGATATCAAT GMPCTGTCT GTrTCGTGAGG ACTCCGTGCC CACCACGGCC TCTITCAGGT GAGTCAAAGG GATI'CCTCAG TT1CACTAGT[ AGGGGAGGTG GGCAGACACC CTGGAGAACT CCCTGGAAAG CTCAACTCTC ATGCCCCGGA CAACAGTTGA AGGAACCATG GTGATG17AA GCCCAAAGAC AAAACCTCTC AGGTGTCCAA GTCCCTGTrG GAATCT17GGG AGCAGAGGGA ATG'TCTGTG GTCTAGAGGA AGAGGGGCTC AGGGAGGAGA AGGGCACATr CCTGGT7GT17 ATATGITTCT ATCTATCCCA GATGAACTG GAAGTGAAGG GAAGAGAG7 AAACATFAAA GTAAATACCC AGTGGATCAG ACAGCAATGT GCCAGAT7GC CTGGAAACA AAATATCTCC AACACATGGC TGACA TTGG TGGGAGATCA GAACACCCTA AAGAGAGAAT TTAAGGGGAG GGGGAGGAGG ACCTGAGCCA GAGTAGAAGC AGAGGATAGG GAGATCTGTT CTGGGGACA GCATTTGCAA GAAACAAGGC TGAGGGGTCC ACTCCAACCT CTCCACCCTG CTGCAGGTGC TGCCTATGAT GAAGATGAGC AGATGGCCAT CTCAGCTGGG GCCACAGTGC ACTGGACCTA TAGT77CCAA T-TCCGCACTC AGCAGGCATC 'FITCTGATGA TCCGATGGCT TCTCAGAGCC AGGGATGGGC CAGGATCCAT CCCCTTGGCT ACTGTCT-rGC TGAGAAATTr ATAAGCAGCA TCTGGTGCTA TA=TIGGTC TCTAGTGAGT TAGCTCATGA AAGATGATAG ACTCTCCAAG CCAGGGGTAT GCAGGAAATG GGTITCTGT AGCTACAGAA ATGGGG'FGA GGGTTrGGACC AAGGGACTAC CCAGGGGAAG TC17ACCTTC AGAGGACTCT GGAAAGGAGG CTGCAAGTT TCATGGGTCA AGAAFTCAGA GCCCAGTAGA GACAGCTrAT CTCTGITrCCA AGATGTCTGG GGCCTTGGrr GGAAGAT7CA AAGGCTAGGA AACCAGGAGC CACCAAAAGC GTAACTGGGG CCAGAGGATC CACTrCAAG GTGGCAAGTT GG'FTCCCCCC ATGTGGCTGC TTGAGTATCC TCACATGGCG GCTCACATCC TTCCAAGTAA GCAATGCAAA AGGCCAAGAA AGATGCTGCA AAGATG'FrAT GACCTAGCCT CAGAAATCAC ACACCATCCC TGCCACCAT[ AGTAAGAAGT CCAGCCCACG TCCAGGAGAA GAGGAAGCAG ATTCCTCCT TrGAAATGAA GAATATCAAG TAATTCGGGG GGCATATGAA AGCCACCACA CACCACAGGG ATCTITFAG AGCATAC=C TlATACCATC ACTGTAGTTC C'FAAGACTC AGGGGCAAAG CCTCACT7CC TTAGCACCCA GTGAAGACCA CGCTTACTCC CTCACTCAAC CTCTGCTAC ITrCCCACCTC TCCTGTCCAA CATCTAGTGT CA=TICCAG AACATACCAA CAGCTTCCCC AGTrCTGTGC CTCTGCTCAG GCTG'PrCCCC CTGCCTGGTC CACTGTCCT CCT7CFIGTC CGGTCAAAAT GCT7~ATC CT-rCAAGACC CAGCTCTAGA GTCACCTCCA ACCCCTTACC CACCAGCCCC CTCTCCAAGT CTGTGTCCCA CAACCCCCCT GCTCCCTCCA GGGCACCCTC CACCCTCTGG GCCACAGTTG TCAGGAGTCA GGCAGGGCAG GGGCCGGGTG GTGTCTrCT-r TGTGT7rrG CACTCAGGGC AGAGCTCAGC ACAGAGCAGA CGCTCAAAAA ACATTTAAAG GATAGAAGCA TTGATI7rGTG GGTCCCCCAG TCTGGCTCCA GGATGCCAGC CAGCTGCTCC TAGAAGCAAA CGGACTITC CTGGGAAATC CCAGAGGTGA TGATCAGTAA TCTCTCCCGT GACTCGTAGT TCAGCTC'1C CTCCATGAGC CTGACTATCA GTGGACC'FC CAGAAAGAGC CCCfT=CCT TCTCTCACCC ACAGCACAGG GCACTGGGAA AATGCCCAAT GAGTCCTGCC TCTGGG'TGT GCT1TTGGACT TT7CAGTGTG TCTCGCATCC ACTCTCAAC TTGAATGTrG CAACAGCCAT GAAAAAAGAA ATGCAAAGCG ATTCAGGATG AGAGCAATAC CCTACTCCAA AGAAGGCAAC ATAGAAGCTC AGAGAGATCA AGCAA T1rGC CCAAGACCAC ACAGCTAGGA GTGGAACTCA TGGCTGTCCA AGCCCCATGC CTCTGCTGAA GGTAGAGATG AA ITACAGCA ACAAGTCTAG AAAGGTGCCT GCCCTATGGT CTGTGAGTCT TGCCTAAGAA TGAAAGAGGA GCCAGTGGGT TAAAGATGAG GTCACCAACA ACGGTGGTGT TGGAGT-I7AC CACTGATAAT AAGGGTGCAA AATGTAAA FF ACTAATGTTT ATTGAGCCTA GTGCAGTGCG TGGGGCA=FI TGCACATlGT CTCTGATCCC TATGACAACC CTGAGAGGTA GTGGTITAA CTGCCATGIT ACAGGTGAGG TCATrGTGGT TCAAGGACGT TAAGTAACTT CCCCAGCGTG ACACGGCTTA TAAGTAAGGC AGCCAGGATG TGAACCCAGT AGGACTATCT GGCTGCAAAG TCCCCACCCC CCTCGCCATC TGTATCCTCC AATCACTCA GTGCTFGCT GCATAGAAGG TAACGGAAAT CACGATGCCA CAGACTGTCC AGGAAGACAG AAACTAGGCA GATGGGCTGG CCATGGTCTC WO 00/09525 PCT/US99/17712 25 CAAGCCAGAC TGGAATCTCC AGGTCTGGAA TGATATCATT TTTCTCrT AATAAATTAA CTCACCCACC ACACGGCTTT GAGAGGCTCA AAGTTGACCA ACTCCCTTGG GAGGGCCCCG G'TTGATAAGG AAGGAACGTG AATCCTCCCA TCACGGAAGC TTCAAGGAGG TCAAGGGTCC AACACTrGAG ATTGTTAGTG CTGTTGGTGG ATACTGGCCA AGGAAATATC CCAGTGGAGC CTCGAGATGA AGAACATGAG GCCCCCGTTT AGAACCAAGG ATCAGAGGGG GCTCTGTAAG ACCCAGGGGA GTCAGGTGCA CTGGAGCGCG GGCATGCAGA AAACAGCCTG AGCTCCACCT CGGCTCTCC TTGTCCTGGC TGGTTGTCCT TAACCCCTGT CTCCTTCTGG ACCAGT1-1 GTCCTTCCCT TGTGACCGCT GAGGGGTAAC AGCCTCTTC CACTTCIT CAGCGCCGAC ATGCTCAATG TCACCTTGCA AGGGCCCACT CTTAACGGGA CCTTTGCCCA GAGCAAATGC CCCCAAGTGG AGTGGCTGGG CTGGCTCAAC ACCATCCAGC CCCCCTTCCT CTGGGTGCTG TTCGTGCTGG CCACCCTAGA GAACATCTTT GTCCTCAGCG TCTTCTGCCT GCACAAGAGC AGCTGCACGG TGGCAGAGAT CTACCTGGGG AACCTGGCCG CAGCAGACCT GATCCTGGCC TGCGGGCTGC CCTTCTGGGC CATCACCATC TCCAACAACT TCGACTGGCT CTTTGGGGAG ACGCTCTGCC GCGTGGTGAA TGCCATTATC TCCATGAACC TGTACAGCAG CATCTGTTTC CTGATGCTGG TGAGCATCGA CCGCTACCTG GCCCTGGTGA AAACCATGTC CATGGGCCGG ATGCGCGGCG TGCGCTGGGC CAAGCTCTAC AGCTTGGTGA TCTGGGGGTG TACGCTGCTC CTGAGCTCAC CCATGCTGGT GTTCCGGACC ATGAAGGAGT ACAGCGATGA GGGCCACAAC GTCACCGCTT GTGTCATCAG CTACCCATCC CTCATCTGGG AAGTGTTCAC CAACATGCTC CTGAATGTCG TGGGCTTCCT GCTGCCCCTG AGTGTCATCA CCTTCTGCAC GATGCAGATC ATGCAGGTGC TGCGGAACAA CGAGATGCAG AAGTTCAAGG AGATCCAGAC GGAGAGGAGG GCCACGGTGC TAGTCCTGGT TGTGCTGCTG CTATTCATCA TCTGCTGGCT GCCCTTCCAG ATCAGCACCT TCCTGGATAC GCTGCATCGC CTCGGCATCC TCTCCAGCTG CCAGGACGAG CGCATCATCG ATGTAATCAC ACAGATCGCC TCCTTCATGG CCTACAGCAA CAGCTGCCTC AACCCACTGG TGTACGTGAT CGTGGGCAAG CGCTTCCGAA AGAAGTCTTG GGAGGTGTAC CAGGGAGTGT GCCAGAAAGG GGGCTGCAGG TCAGAACCCA TTCAGATGGA GAACTCCATG GGCACACTGC GGACCTCCAT CTCCGTGGAA CGCCAGATTC ACAAACTGCA GGACTGGGCA GGGAGCAGAC AGTGAGCAAA CGCCAGCAGG GCTGCTGTGA ATTTGTGTAA GGATTGAGGG ACAGTTGCTTr TTCAGCATGG GCCCAGGAAT GCCAAGGAGA CATCTATGCA CGACCTTGGG AAATGAGTrG ATGTCTCCGG TAAAACACCG GAGACTAATT CCTGCCCTGC CCAATTTGC AGGGAGCATG GCTGTGAGGA TGGGGTGAAC TCACGCACAG CCAAGGACTC CAAAATCACA ACAGCATTAC TGTTCTTATT TGCTGCCACA CCTGAGCCAG CCTGCTCCTT CCCAGGAGTG GAGGAGGCCT GGGGGCAGGG AGAGGAGTGA CTGAGCTTCC CTCCCGTGTG TTCTCCGTCC CTGCCCCAGC AAGACAACT AGATCTCCAG GAGAACTGCC ATCCAGCTTT GGTGCAATGG CTGAGTGCAC AAGTGAGTTG TTGCCCTGGG TTTCTTTAAT CTATTCAGCT AGAACTGA AGGACAATTT CTTGCATTAA TAAAGGFAA GCCCTGAGGG GTCCCTGATA ACAACCTGGA GACCAGGAT7 TTATGGCTCC CCTCACTGAT GGACAAGGAG GTCTGTGCCA AAGAAGAATC CAATAAGCAC ATATTGAGCA CTTGCTGTAT ATGCAGTATT GAGCACTGTA GGCAAGAGGG AAGAAAGAGA AGGAGCCATC TCCATCTTGA AGGAACTCAA AGACTCAAGT GGGAACGACT GGGCACTGCC ACCACCAGAA AGCTGTTCGA TGAGACGGTC GAGCAGGGTG CTGTGGGTGA TATGGACAGC AGAAGGGGGA GCCAGGTTCC AGCTCACCAA TACTATTGCA CACCACCTGT CCTGCCTC CTGCAGAAAA CAGCCTGAGC TCCACCTCGG CTTCTCCTTG CCCTGGCTGG TTGTCCTTAA CCCCTGTCTC CTTCTGGACC AGTlITIGTC CTTCCCTTGT GACCCTGAGG GGTAACAGCC TCTTliCCAC TTTCTTTCAG CGCCGACATG CTCAATGTCA CCTTGCAAGG GCCCACTCTT AACGGGACCT TTGCCCAGAG CAAATGCCCC CAAGTGGAGT GGCTGGGCTG GCTCAACACC ATCCAGCCCC CCTCCTCTG GGTGCTGTTC GTGCTGGCCA CCCTAGAGAA CATCTTTGTC CTCAGCGTCT TCTGCCTGCA CAAGAGCAGC TGCACGGTGG CAGAGATCTA CCTGGGGAAC CTGGCCGCAG CAGACCTGAT CCTGGCCTGC GGGCTGCCCT TCTGGGCCAT CACCATCTCC AACAACTTCG ACTGGCTCTT TGGGGAGACG CTCTGCCGCG TGGTGAATGC CATTATCTCC ATGAACCTGT ACAGCAGCAT CTGTTTCCTG ATGCTGGTGA GCATCGACCG CTACCTGGCC CTGGTGAAAA CCATGTCCAT GGGCCGGATG CGCGGCGTGC GCTGGGCCAA GCTCTACAGC TTGGTGATCT GGGGGTGTAC GCTGCTCCTG AGCTCACCCA TGCTGGTGTT CCGGACCATG AAGGAGTACA GCGATGAGGG CCACAACGTC ACCGCTTGTG TCATCAGCTA CCCATCCCTC ATCTGGGAAG TGTTCACCAA CATGCTCCTG AATGTCGTGG GCTTCCTGCT GCCCCTGAGT GTCATCACCT TCTGCACGAT GCAGATCATG CAGGTGCTGC GGAACAACGA GATGCAGAAG TTCAAGGAGA TCCAGACGGA GAGGAGGGCC ACGGTGCTAG TCCTGGTTGT GCTGCTGCTA TTCATCATCT GCTGGCTGCC CTTCCAGATC AGCACCTTCC TGGATACGCT GCATCGCCTC GGCATCCTCT CCAGCTGCCA GGACGAGCGC ATCATCGATG TAATCACACA GATCGCCTCC TrCATGGCCT ACAGCAACAG CTGCCTCAAC CCACTGGTGT ACGTGATCGT GGGCAAGCGC TTCCGAAAGA AGTCTTGGGA GGTGTACCAG GGAGTGTGCC AGAAAGGGGG CTGCAGGTCA GAACCCATTC AGATGGAGAA CTCCATGGGC ACACTGCGGA CCTCCATCTC CGTGGAACGC CAGATTCACA AACTGCAGGA CTGGGCAGGG AGCAGACAGT GAGCAAACGC CAGCAGGGCT GCTGTGAATT TGTGTAAGGA TTGAGGGACA GTTGCTTC AGCATGGGCC CAGGAATGCC AAGGAGACAT CTATGCACGA CCT7GGGAAA TGAGTTGATG TCTCCGGTAA AACACCGGAG ACTAATTCCT GNCCTGCCCA ATTGCAGG GAGCATGGCT GTGAGGATGG GGTGAACTCA CGCACAGCCA AGGACTCCAA AATCACAACA GCATTACTGT TCTTATTTGC TGCCACACCT GAGCCAGCCT GCTCCTTCCC AGGAGTGGAG GAGGCCTGGG GGCAGGGAGA GGAGTGACTG AGCTTCCCTC CCGTGTGTTC TCCGTCCCTG CCCCAGCAAG ACAACTTAGA TCTCCAGGAG AACTGCCATC CAGCTTTGGT GCAATGGCrG AGTGCACAAG TGAGTrGTG CCCTGGGTTT CTTTAATCTA TrCAGCTAGA ACTTTGAAGG ACAATTCTT GCATTAATAA AGGTTAAGCC CTGAGGGGTC CCTGATAACA ACCTGGAGAC CAGGATTA TGGCTCCCCT CACTGATGGA CAAGGGAGGT CTGTGCCAAA GAAGAATCCA ATAAGCACAT ATTGAGCACT TGCTGTATAT GCAGTATTGA GCACTGTAGG CAAGAGGGAA GAAAGAGAAG GAGCCATCTC CATCTTGAAG GAACTCAAAG ACTCAAGTGG GAACGACTGG CACTGCCACC ACCAGAAAGC TGTTCGACGA GACGGTCGAG CAGGGTGCTG TGGGTGATAT GGACAGCAGA AGGGGGAGAC CAAGGTTCCA GCTCAACCAA TAACTATrGC ACAACCACCT GTCCCTGCCT CAGTrCCCTC 7CTGTAACA TGAAGTCGTT GTGAGGGTTA AAGGCAGTAA CAGGTATAAA GTACTAGAA AAGCAAAGGG TGCTACGTAC ATGTGAGGCA TCATTACGCA GACGTAACTG GGATATGTTT ACTATAAGGA AAAGACACTG AGGTCTAGA TGATCCTATC ACAACCTGAG AGTAGTTIT ACTCCATTA CAGGTGAGGT CATTGTGGTT CAAGGACGTT WO 00/09525 PCT/US99/17712 EPI-109 26 AAGTAACTTC CCCAGCTCAC ACGGCTTATA AGTAAGGCAG CCAGGATGTG AACCCAGTAG GACTATCTGG CTGCAAAGTC CCCACCCTCC CTCGCCATCT GTATCCTCCA ATCATCTTCA GTGCTTTGCT GATAGAAGGT ACGGAAATAC GATGCCACAG ACTGTCCAGG AAGACAGAAA CTAGGCAGAT GGGCTGGCCA TGGTCTCCAA GCCAGACTGG AATCTCCAGG TCTGGAATGA TATCATT CTC1ThIAAT AAATTAACTC ACCCACCACA CGGCTTGAG AGGCTCAAAG GTGACCAACT CCCTTGGGAG GGCCCCGGTT GATAAGGAAG GAATGTGAAT CCTCCCATCA CGGAAGCTTC AAGGAGGTCA AGGGTCCAAC ACTTGAGATT GTTAGTGCTG TTGGTGGATA CTGCAGAATA TCCAGTGGAG CCTCAGATGA AGAACATGAG GCCCCGTMTA GATCCAAGGA TCAGAGGGGG CTCTGTAAGA CCCAGGGGAG TCAGGTGCAC TGGAGCGCGG GCTGCAGAAA ACAGCCTGAG CTCCACCTCG GCTrCTCCTT GCCCTGGCTG GTTGTCCTTA ACCCCTGTCT CCTTCTGGAC CAGTITGT CCTTCCCTTG TGACCTGAGG GGTAACAGCC TCTTTTCCAC TTTCTTTCAG CGCCGACATG CTCAATGTCA CCTTGCAAGG GCCCACTCTT AACGGGACCT TTGCCCAGAG CAAATGCCCC CAAGTGGAGT GGCTGGGCTG GCTCAACACC ATCCAGCCCC CCTTCCTCTG GGTGCTGTTC GTGCTGGCCA CCCTAGAGAA CATCTTTGTC CTCAGCGTCT TCTGCCTGCA CAAGAGCAGC TGCACGGTGG CAGAGATCTA CCTGGGGAAC CTGGCCGCAG CAGACCTGAT CCTGGCCTGC GGGCTGCCCT TCTGGGCCAT CACCATCTCC AACAACTTCG ACTGGCTCTT TGGGGAGACG CTCTGCCGCG TGGTGAATGC CAT7ATCTCC ATGAACCTGT ACAGCAGCAT CTGTTTCCTG ATGCTGGTGA GCATCGACCG CTACCTGGCC CTGGTGAAAA CCATGTCCAT GGGCCGGATG CGCGGCGTGC GCTGGGCCAA GCTCTACAGC TTGGTGATCT GGGGGTGTAC GCTGCTCCTG AGCTCACCCA TGCTGGTGTT CCGGACCATG AAGGAGTACA GCGATGAGGG CCACAACGTC ACCGCTTGTG TCATCAGCTA CCCATCCCTC ATCTGGGAAG TGTFCACCAA CATGCTCCTG AATGTCGTGG GCTTCCTGCT GCCCCTGAGT GTCATCACCT TCTGCACGAT GCAGATCATG CAGGTGCTGC GGAACAACGA GATGCAGAAG TTCAAGGAGA TCCAGACGGA GAGGAGGGCC ACGGTGCTAG TCCTGGT7GT GCTGCTGCTA TTCATCATCT GCTGGCTGCC CTTCCAGATC AGCACCTTCC TGGATACGCT GCATCGCCTC GGCATCCTCT CCAGCTGCCA GGACGAGCGC ATCATCGATG TAATCACACA GATCGCCTCC TTCATGGCCT ACAGCAACAG CTGCCTCAAC CCACTGGTGT ACGTGATCGT GGGCAAGCGC TTCCGAAAGA AGTCTrGGGA GGTGTACCAG GGAGTGTGCC AGAAAGGGGG CTGCAGGTCA GAACCCATTC AGATGGAGAA CTCCATGGGC ACACTGCGGA CCTCCATCTC CGTGGAACGC CAGATTCACA AACTGCAGGA CTGGGCAGGG AGCAGACAGT GAGCAAACGC CAGCAGGGCT GCTGTGAATT TGTGTAAGGA TTGAGGGACA GTTGCITTC AGCATGGGCC CAGGAATGCC AAGGAGACAT CTATGCACGA CCTTGGGAAA TGAGTGTTGA TGTCTCCGGT AAAACACCGG AGACTAATTC CTGCCCTGCC CAATTTTCGA GGGAGCATGG CTGTGAGGAT GGGGTGAACT CACGCACAGC CAAGGACTCC AAAATCACAA CAGCATTACT GTrCTTAT GCTGCCACAC CTGAGCCAGC CTGCTCCTTC CCAGGAGTGG AGGAGGCCTG GGGGAGGGAG AGGAGTGACT GAGCTTCCCT CCCGTGTGTT CTCCGTCCCT GCCCCAGCAA GACAACTTAG ATCTCCAGGA GAACTGCCAT CCACGTTTGG TGCAATGGCT GAGTGCACAA GTGAGTTGTT GCCCTGGGTT TCTTTAATCT ATCAGCTAGA ACTTTGAAGG ACAATTTCTr GCATTAATAA AGGTTAAGCC CTGAGGGGTC CCTTGATAAC AACCTGGAGA CCAGGATT ATGGCTCCCC TCACTGATGG ACAAGGAGGT CTGTGCCAAA GAAGAATCAA TAAGCACATA TGAGCAC1C TGTATATCAG TATTGAGCAC TGTAGGCA ATGTTCTCTC CCTGGAAGAT ATCAATGTTT CTGTCTGT' GTGAGGACTC CGTGCCCACC ACGGCCTCTT TCAGCGCCGA CATGCTCAAT GTCACCTTGC AAGGGCCCAC TCTTAACGGG ACCTTTGCCC AGAGCAAATG CCCCCAAGTG GAGTGGCTGG GCTGGCTCAA CACCATCCAG CCCCCCTTCC TCTGGGTGCT GTTCGTGCTG GCCACCCTAG AGAACATCTT TGTCCTCAGC GTCTTCTGCC TGCACAAGAG CAGCTGCACG GTGGCAGAGA TCTACCTGGG GAACCTGGCC GCAGCAGACC TGATCCTGGC CTGCGGGCTG CCCTTCTGGG CCATCACCAT CTCCAACAAC TTCGACTGGC TC1TTGGGGA GACGCTCTGC CGCGTGGTGA ATGCCATTAT CTCCATGAAC CTGTACAGCA GCATCTGTTT CCTGATGCTG GTGAGCATCG ACCGCTACCT GGCCCTGGTG AAAACCATGT CCATGGGCCG GATGCGCGGC GTGCGCTGGG CCAAGCTCTA CAGCTTGGTG ATCTGGGGGT GTACGCTGCT CCTGAGCTCA CCCATGCTGG TGTTCCGGAC CATGAAGGAG TACAGCGATG AGGGCCACAA CGTCACCGCT TGTGTCATCA GCTACCCATC CCTCATCTGG GAAGTGTrCA CCAACATGCT CCTGAATGTC GTGGGCTTCC TGCTGCCCCT GAGTGTCATC ACCTTCTGCA CGATGCAGAT CATGCAGGTG CTGCGGAACA ACGAGATGCA GAAGTTCAAG GAGATCCAGA CGGAGAGGAG GGCCACGGTG CTAGTCCTGG TTGTGCTGCT GCTATTCATC ATCTGCTGGC TGCCCTTCCA GATCAGCACC TTCCTGGATA CGCTGCATCG CCTCGGCATC CTCTCCAGCT GCCAGGACGA GCGCATCATC GATGTAATCA CACAGATCGC CTCCTTCATG GCCTACAGCA ACAGCTGCCT CAACCCACTG GTGTACGTGA TCGTGGGCAA GCGCTTCCGA AAGAAGTCT GGGAGGTGTA CCAGGGAGTG TGCCAGAAAG GGGGCTGCAG GTCAGAACCC ATTCAGATGG AGAACTCCAT GGGCACACTG CGGACCTCCA TCTCCGTGGA ACGCCAGATr CACAAACTGC AGGACTGGGC AGGGAGCAGA CAGTGAGCAA ACGCCAGCAG GGCTGCTGTG AATTGTGTA AGGATTGAGG GACAGTTGCT T ATGTTCTCTC CCTGGAAGAT ATCAATGTTT CTGTCTGTTC GTGAGGACTC CGTGCCCACC ACGGCCTCTT TCAGCGCCGA CATGCTCAAT GTCACCTTGC AAGGGCCCAC TCTTAACGGG ACCTTTGCCC AGAGCAAATG CCCCCAAGTG GAGTGGCTGG GCTGGCTCAA CACCATCCAG CCCCCCTTCC TCTGGGTGCT GTTCGTGCTG GCCACCCTAG AGAACATCTT TGTCCTCAGC GTCTTCTGCC TGCACAAGAG CAGCTGCACG GTGGCAGAGA TCTACCTGGG GAACCTGGCC GCAGCAGACC TGATCCTGGC CTGCGGGCTG CCC'TTCTGGG CCATCACCAT CTCCAACAAC TTCGACTGGC TCTTGGGGA GACGCTCTGC CGCGTGGTGA ATGCCATTAT CTCCATGAAC CTGTACAGCA GCATCTGTTT CCTGATGCTG GTGAGCATCG ACCGCTACCT GGCCCTGGTG AAAACCATGT CCATGGGCCG GATGCGCGGC GTGCGCTGGG CCAAGCTCTA CAGCTTGGTG ATCTGGGGGT GTACGCTGCT CCTGAGCTCA CCCATGCTGG TGTTCCGGAC CATGAAGGAG TACAGCGATG AGGGCCACAA CGTCACCGCT TGTGTCATCA GCTACCCATC CCTCATCTGG GAAGTGTTCA CCAACATGCT CCTGAATGTC GTGGGCTTCC TGCTGCCCCT GAGTGTCATC ACCTTCTGCA CGATGCAGAT CATGCAGGTG CTGCGGAACA ACGAGATGCA GAAGTTCAAG GAGATCCAGA CGGAGAGGAG GGCCACGGTG CTAGTCCTGG TTGTGCTGCT GCTATTCATC ATCTGCTGGC TGCCCTTCCA GATCAGCACC TrCCTGGATA CGCTGCATCG CCTCGGCATC CTCTCCAGCT GCCAGGACGA GCGCATCATC GATGTAATCA CACAGATCGC CTCCTTCATG GCCTACAGCA ACAGCTGCCT CAACCCACTG GTGTACGTGA TCGTGGGCAA GCGCTTCCGA AAGAAGTCTT GGGAGGTGTA CCAGGGAGTG TGCCAGAAAG GGGGCTGCAG GTCAGAACCC WO 00/09525 PCT/US99/17712 27 ATTCAGATGG AGAACTCCAT GGGCACACTG CGGACCTCCA TCTCCGTGGA ACGCCAGATT CACAAACTGC AGGACTGGGC AGGGAGCAGA CAGTGAGCAA ACGCCAGCAG GGCTGCTGTG AATTTGTGTA AGGATTGAGG GACAGTTGCT T GCCCTrCAAA GATGAGCTGT TCCCGCCGCC ACTCCAGCTC TGGCTTCTGG GCTCCGAGGA GGGGTGGGGA CGGTGGGGAC ATCAGGCTGC CCCGCAGTAC CAGGGAGCGA CTGAAGTGCC CATGCCGCTT GCTCCGGAGA AGGTGGGTGC CGGGCAGGGG CTGCTCCAGC CGCCTCACCT CTGCTGGGAG GACAAACTGT CCCAGCACAG AGGGAGGGAG GGAGGGCAGG CAGCGGGGAG AAGT-TCCCT GTGGTCGTGG GGAGTT GCCCTTCAAA GATGAGCTGT TCCCGCCGCC ACTCCAGCTC TGGCTTCTGG GCTCCGAGGA GGGGTGGGGA CGGTGGTGAC GGTGGGGACA TCAGGCTGCC CCGCAGTACC AGGGAGCGAC TGAAGTGCCC ATGCCGCTTG CTCCGGAGAA GGTGGGTGCC GGGCAGGGGC TGCTCCAGCC GCCTCACCTC TGCTGGGAGG ACAAACTGTC CCAGCACAGA GGGAGGGAGG GAGGGCAGGC AGCGGGGAGA AGTTTCCCTG TGGTCGTGGG GAGTr GAGCTCTTCA ATATTTAGT GAAAGCTATA GATGAGGCTC CATAGGGGAT AAAGCACAGA CACACC1111 CAGAGGGCTT GTGGACTCTG GGCAGCCTGT CCATAGACCT CTGTCCCCAA CTGGCAAGTC AGGAAACTCC AGATTAAGGA GCCCCAATGT GGTTGAACAG CCAGGTGCAC AGATGAGTCA ACCACACAGC CAGGCCAGGG AGGGCCTTCA CTCAAGAGCC TACAGCCAGT TCACAGCCAA GCCAGGGCTA GCGCCAGGCC ACCCATAAAC TGATCTGAGA CTCTGTTCC CTGTCTCCAT GATGATGGGA TCAGGCTTGA TrGCTGGTTT GTAGGCTTGT TATGAATCAA GTCACAGGGA AGAGGAGCTG ATGGGCTGGG GGGACGTCCT CTGGCCCTCC TGTCTCTTCC CCAGATCCAC TGGGCCCACT CTTATCTGTT CTCTTCTGAA GGAAGGGTTT TAAGGCTTCA AAAAAAAATG =TTTGAAAGT CCCTGCCCTT TCCAGCTCCT ACCGTCTCAG CCCTGGGAGT GTAAAGTGCT GCAGATAGTT AGTAAGTCTT TGAGCAAAAC TGAGAAAGCC AGCCTGAGCC TTGACATGGG AGAAACCTCC GCCATACATC TCCGAAGAAA CGGCCGCGTG TCTCAGGGGA GCGCAAACAC CCGTACCCAG GAAACAGGAC AGCTTCTGCC ACTGTCGCCC TTGGGAGCCG TACGTGGCAT GACAAAGAAA TCCCAGGACT CCGCCTGCCC ACCTGGCCAC CCTCTGTTTA CACCTTCCGC GTAAACGCCC ACTGTTTACA TCCAAAACTC AGACACAAAA TAACCACCTC AAGAAGATAA ATAATGATAA GAAATAAATG TTACGCGAGG CAAATTrATr CACATGGGGC TTCCCAGGCC ACTTTGTGGT CAGCCGGGAG GGACGTTTTT GCCGTCCCAC GACTCCAACG GGCAGCCGGG CCTACGCAAA CATGGAAATC TTCCAAGAGC CTCCCTGGCC CCCAGGGCTC AGAGGGTGGC AGAGCGGAGA GCGAAGGTGG CCGCAGCCTT CCCGGCCCCA CAGCCAGCCT GGCTCCAGCT GGGCAGGAGT GCAGAGCTCA GCTGGAGGCG AGGGGGAAGT GCCCAGGAGG CTGATGACAT CACTACCCAG CCCTTCAAAG ATGAGCTGTT CCCGCCGCCA CTCCAGCTCT GGCTTCTGGG CTCCGAGGAG GGGTGGGGAC GGTGGTGACG GTGGGGACAT CAGGCTGCCC CGCAGTACCA GGGAGCGACT GAAGTGCCCA TGCCGCTTGC TCCGGAGAAG GTGGGTGCCG GGCAGGGGCT GCTCCAGCCG CCTCACCTCT GCTGGGAGGA CAAACTGTCC CAGCACAGAG GGAGGGAGGG AGGGCAGGCA GCGGGGAGAA GTTTCCCTGT GGTCGTGGGG AGTrGGGAAA AGTTCCCTTC CTTCCGGAGG GAGG CAGATTCACA AACTGCAGGA CTGGGCAGGG AGCAGACAGT GAGCAAACGC CAGCAGGGCT GCTGTGAATT TGTGTAAGGA T7GAGGGACA GTTGCI iC AGCATGGGCC CAGGAATGCC AAGGAGACAT CTATGCACGA CCTTGGGAAA TGAGTrGATG TCTCCGGTAA AACACCGGAG ACTAATTCCT GCCCTGCCCA ATTTTGCAGG GAGCATGGCT GTGAGGATGG GGTGAACTCA CGCACAGCCA AGGACTCCAA AATCACAACA GCATrACTGT TCATITGC TGCCACACCT GAGCCAGCCT GCTCCTTCCC AGGAGTGGAG GAGGCCTGGG GGGAGGGAGA GGAGTGACTG AGCTTCCCTC CCGTGTGTTC TCCGTCCCTG CCCCAGCAAG ACAACTTAGA TCTCCAGGAG AACTGCCATC CAGCITGGT GCAATGGCTG AGTGCACAAG TGAGTrGTTG CCCTGGGT CTTTAATCTA TTCAGCTAGA ACTTGAAGG ACAATTTCTT GCATTAATAA AGGTTAAGCC CTGAGGGGTC CCTGATAACA ACCTGGAGAC CAGGATTTTA TGGCTCCCCT CACTGATGGA CAAGGAGGTC TGTGCCAAAG AAGAATCCAA TAAGCACATA TTGAGCACTT GCTGTATATG CAGTATTGAG CACTGTAGGC AAGACCCAAG AAAGAGAAGG AGCCATCTCC ATCTTGAAGG AACTCAAAGA CTCAAGTGGG AACGACTGGG CACTGCCACC ACCAGAAAGC TGTTCGACGA GACGGTCGAG CAGGGTGCTG TGGGTGATAT GGACAGCAGA AGGGGGAGAC CAAGGTTCCA GCTCAACCAA TAACTATTGC ACAACCACCT GTCCCTGCCT CAGTTCCCTT TTATGTAACA TGAAGTCGTT GTGAGGGTTA AAGGCAGTAA CAGGTATAAA GTACTrAGAA AAGCAAAGGG TGCTACGTAC ATGTGAGGCA TCATTACGCA GACGTAACTG GGATATGTTT ACTATAAGGA AAAGACACTG AGGTCTAGAA ATAGCTCCGT GGAGCAGAAT CAGTATTGGG AGCCGGTGGC GGTGTGAAGC ACCAGTGTCT GGCACACAGT AGGTGCTCAT TGGCTCCCTT CCACCTGTCA TTCCCACCAC CCTGAGGCCC CAACCGCCAC ACACACAGGA GCATTTGGAG AGAAGGCCAT GTCTTCAAAG TCTGATGT GATGAGGCAG AGGAAGATAT TTCTAATCGG TCTTGCCCAG AGGATCACAG TGCTGAGACC CCCCACCACC AGCCGGTACC TGGGAAGGGG GAGAGTGCAG GCCTGCTCAG GGACTGTrCC TGTCTCAGCA ACCAAGGGAT TGTTCCTGTC AATCAATGGT TTATTGGAAG GTGGCCCAGT ATGAGCCCTA GAAGAGTGTG AAAAGGAATG GCAATGGTGT TCACCATCGG CAGTGCCAGG GCAGCACTCA TTCACTTGAT AAATGAATAT TTATTAGCTG GTTGGAGAGC TAGAACCTGG AGAGCTAGAA CCTGGAGAAC TAGAACCTGG AGGGCTAGAA CCTGGAGAGG CTAGAACCAA GAAGGGCTAG AACCTGGAGG GGCTAGAACC TAGAGAAGCT AAAACCTGAG CTAGAAGCTG GAGGACTAGA ACCTGGAGGG CTGGAATCTG AAGGGCTAGA ACCTGGAGGG CTGGAATCTG GAGAGCTAGA ACCTGGAGGG CTAGAACCTG GAGGGCTAGA ACCTAGAAGG GCTAGAACCT GGAGGGCTGG AATCTGGAGA GCTAGAACCT GGAGGGCTAG AACCTGGAGG GCTAGAACCT AGAAGGGCTA GAACCTGGAG GGCTAGAACC TGGCAGGTTA GAACCTAGAA GGGCTAGAAC CTGGAGAGCC AGAACCTGGA GGGCTAGAAC CTGGAAGGGC TAGAACCTGT AGAGCTAGAA CATGGAGAGC TAGAACCCGG CAGGCTAGAA CCTGGCAAGC TAGAACCTGG AGGGAATGAA CCTGGAGGGC TAGAACCTGG AGAATGAGAA AAATTTACAT GGCAAAGAGC CCATAAATCC TGACCAATCC AACTCTGAAT 7TAAAGCAA AAGCGTGAAA AAAAAGATTC CCTCCTTACC CCCAACCCAC TCT-Ti CC CACCACCCAC TCTCCTCTGC CTCAGTAAGT ATCTGGAGGA AGAAAACAGG TGAAAGAAGA AGTAAAAACC ATMTAGTATT AGTATrAGAA TGAAGTCAAA CTGTGCCACA CATGGTGAAT GAAAAAAAAA AAAAAGAGGC TGTGTITTGT CACACAGGGC AGTCATTCAG CACCAGAGCA CGTGATGGTC TGAGACTCTC TTAGGAGCAG AGCTCTGCCG CAATGGCCAT GTGGGGATCC ACACCTGGTC TGAGGGGCAA CTGAGTCTGC GGGAGAAGAG CGGCCCTATG CATGGTGTAG ATGCCCTGAT AAAGAACATC TGTCCTGTGA AAGACTCAAT GAGCTGTTAT GTTGTAAACA GGAAGCATTT CACATCCAAA CGAGAAAATC ATGTAAACAT WO 00/09525 PCT/US99/1 7712 EPI-109 28 GTGTCTFIC TGTAGAGCAT AATAAATGGA TGAGG7flT GCAAAAAAAA AAAAAAAAA AAATGATAGA CCGTCAATAA TITGTTAAAT GC7IJ=AAA ATGAATGC2Fr TAAGCCGGGT GCAGTGCCTC ACATCTGTAA TCCCAGCACT rrGGAGCCGA GCGGGTGGAT TGTGTGAGGT CAGGAG~rCG AGACCAACCT GGCCAACATG GCAAAACCTC ACTCTCTACC AAAAATACAA AAATTAGCCA GGCATGGTGG CAGGCACCTG TGATCCCAGC TACTCAGGAG GCTGAGACAG GAGAATCGCT TGAACCCGGG AGGCAAGGTT GCAGTGAGCC AAGATTACGC CATTGTACTC CAGCCTGGGT GACAGAGAGA GACTCCGTCT CAAAAAAAAA AAAAAAAAAA AAAAAATI7AC G=rCAAACA CATGATCTCT CACCACTGTT GAA7==r'I TCTATGAGCC CAGGAGGGCC TCTCAGAGAG GAAAGCTrCCT AGGTCrrCCT 'FrCCCTCTGC AAACrCCCTG CCTTGAAGGT TCAGAAGGAC TGTGCGTGCT CGTFGCATCC '1TGCAAGTG TCCAAACCCT GATCCCAGCT GTGCT[AGGG G'rrCCTGCAA ACCTITCCA GGTGTrAATr ACCTCCCACT TCATICCTG TTTACCAACT CAGCTITG =IIAGTGTG 'I1rGAATrCC CTGAACTGAC CGTTGTCTGA TCTCCACCTC CCAACTGAAT TAGGGGAGCT GGGCTTCTGG AAACCCAGGT GCCGGGTGTl GCAGAGTGGC TGAAAGCTGG GATGTGGCAG ATCCGTGGCT ACA'ITCATGC ACACACACAC ACCCACATAC CCACACATGC ACACACACAC ACACACCCGC ACTCACACAC TrGGACATGC ATAGACCACA GCI=CCACA CCCTTCCTAG ACAGGGGTCA CTrGGTATCC TGGAGAGAGT GTGAAGTCCT GGAATGGAAA GAGGGGGGAT TAAGCCCCAC CTCTAGCCAT GGGACTGAGA CAAGTCACCA CCAACCCATC TGCGCCT7GT TFACCTCCTC TGTGAGGCAA GCACAGAGCC CATGCCTGCC CCCCTGGATG GGAGTGATGT GAAACTTGAA GGGCGGTCAG AGCAAGGGTC GGGAATGGAA GGCCCTTGGG AAAAAAGGCC CITCAACTA GGGGCACAGA GGAGGCCCTG GGCTGAGAAC TrGACAGCAC =TGTAIT7G GTAAGCCAAG CCCGAAGGGA CTGGAAATAC TCAGATGTGT CTGTCTCCCT TATTAGGTrC AAAGTCCCTC AAGACCCTGT CTCCATCACA GTGCTCCAGT CCAGACCCCT CCTCTGAGCT CCAGACCCTG CTGGACCCAA CCAGCCCTAT GGGGTCGCAT CCCCACCTGC CTGGAATTCT CCAAAGAACC TCCCC1TAA CAGTTCCAGC ='TAACAGT TCCAGTCTAA ACACATGACC =TCTCCTCT AAATCAGCCC CCCATCTCTG CCTTGCAGG AGATGGAAGC CATGACACCT GCCTCGCCCC TGTCCTCACC CCATCCATGT CCAATCAAGC ACTAGGCATG TCAGG=rAC CCTCTAAACT CCTCTGGAAT CCAGTCTCTC AGTCTCCATC ATCCCAGGTC GAAGCTAATG GGCTAACTGG TCCTGCT-rC CACTCTACCC CCACTGCAGT CCTGACT7CC TGAGCAGCAG CCAGGGCCTA ATCGATATrC ACACCAAGCG CCAACCTGAC TGAGATATCC TCCTGCACCA TCATCCCTCC ACCCTGTI'A GTI'CTGCTCA CCCTCAGTGT TCTCATCAAT AATCCACTCC CCTCACAGGC GCGT7GGGA CCCCATGTrC TATGCTCTCA CAGGACCTF TG=TGAMT T-TCACTGTAC 'FIAGGTCAGT 'FrGCAGTrAT TAAGTGACTG AGCAATGTCT GG=TCTCCA GTAGACTGTC AGCTCCTAGC CAYTGTATAC CTAGCACCGC TGTGTGGGAG CACGTGACAA ACGTCCAGTG AGTCAGGGAC TCAGCAGTCT CCATI17CTCC GCCCTGCTGG AGAATGCGTG TA'TrGGCAA TCCCCAGCCC CTGTGCCATC TAACCATCT 7r=TCTCTG 17CAGCCCAG GTGTGGCCTC ACTCACATCC CACTCTGAGT CCAAATGF[C TCTCCCTGGA AGATATCAAT GTICTGTCT GITCGTGAGG ACTCCGTGCC CACCACGGCC T='~CAGGT GAGTCAAAGG GATTCCTCAG T7CACTAGF7 AGGGGAGGTG GGCAGACACC CTGGAGAACT CCCTGGAAAG CTCAACITC ATGCCCCGGA CAACAGTTGA AGGAACCATG GTGATGTrAA GCCCAAAGAC AAAACCTCTC AGGTGTCCAA GTCCCTGT7G GAATCF1GGG AGCAGAGGGA ATGTW1rGTG GTCTAGAGGA AGAGGGGCrC AGGGAGGAGA AGGGCACATT CCTGGTrGUT ATATG'I=CT ATCTATCCCA GATGAACTrG GAAGTGAAGG GAAGAGAGTT AAACA'FrAAA GTAAATACCC AGTGGATCAG ACAGCAATGT GCCAGATTGC =TGGAAACA AAATATCTCC AACACATGGC TGACATI1GG TGGGAGATCA GAACACCCTA AAGAGAGAAT TTAAGGGGAG GGGGAGGAGG ACCTGAGCCA GAGTAGAAGC AGAGGATAGG GAGATCTGTT CTIGGGGACA GCATIGCAA GAAACAAGGC TGAGGGGTCC ACTCCAACCT CTCCACCCTG CTGCAGGTGC TGCCTATGAT GAAGATGAGC AGATGGCCAT CTCAGCTGGG GCCACAGTGC ACTGGACCTA TAGrTCCAA TrCCGCACTC AGCAGGCATC 7TrCTGATGA TCCGATGGCT TCTCAGAGCC AGGGATGGGC CAGGATCCAT CCCCTGGCT ACTGTCFTGC TGAGAAAITT7 ATAAGCAGCA TCTGGTGCTA TACTTGGTC TCTAGTGAGT TAGCTCATGA AAGATGATAG ACTCTCCAAG CCAGGGGTAT GCAGGAAATG GGT1TCTGT AGC-rACAGAA ATGGGGTTGA GGGTTGGACC AAGGGACTAC CCAGGGGAAG TCT]TACCTTC AGAGGACTCT GGAAAGGAGG CTGCAAGTI7 TCATGGGTCA AGAA'FrCAGA GCCCAGTAGA GACAGCTTAT CTCTGT'TCCA AGATGTCTGG GGCCTTGGTT GGAAGA17CA AAGGCTAGGA AACCAGGAGC CACCAAAAGC GTAACTGGGG CCAGAGGATC CACTICAAG GTGGCAAGfl GGTrCCCCCC ATGTGGCTGC TI'GAGTATCC TCACATGGCG GCTCACATCC 7rCCAAGTAA GCAATGCAAA AGGCCAAGAA AGATGCTGCA AAGATGTTAT GACCTAGCCT CAGAAATCAC ACACCATCCC TGCCACCATT AGTAAGAAGT CCAGCCCACG TCCAGGAGAA GAGGAAGCAG ATTCCTC= T ITGAAATGAA GAATATCAAG TAAT7CGGGG GGCATATGAA AGCCACCACA CACCACAGGG ATC'TI=AG AGCATACTTC Y[ATACCATC ACTGTAGTrC CTTAAGACTC AGGGGCAAAG CCTCACT7CC 7rAGCACCCA GTGAAGACCA CGCITACTCC CTCACTCAAC CTCTI'GCTAC T'TCCCACCTC TCCTGTCCAA CATCTAGTGT CA=r~CCAG AACATACCAA CAG=TCCCC AG~rCTGTGC CTCTGCTCAG GCTGT7CCCC CTGCCTGGTC CACTTGT0CT C==C~GTC CGGTCAAAAT G==CTATC CTTCAAGACC CAGCTCTAGA GTCACCTCCA ACCCCTrACC CACCAGCCCC CTCTCCAAGT CTGTGTCCCA CAACCCCCCT GCTCCCTCCA GGGCACCCTC CACCCTCTGG GCCACAGTTG TCAGGAGTCA GGCAGGGCAG GGGCCGGGTG GTGTCTTCT7 TGTGTr=TG CACTCAGGGC AGAGCTCAGC ACAGAGCAGA CGCTCAAAAA ACAFIAAAG GATAGAAGCA TrGA'I=GTG GGTCCCCCAG TCTGGCTCCA GGATGCCAGC CAGCTGCTCC TAGAAGCAAA CGGACTTIC CTGGGAAATC CCAGAGGTGA TGATCAGTAA TCTCTCCCGT GACTCGTAGT TCAGCT=TC CTCCATGAGC CTGACTATCA GTGGAC=TC CAGAAAGAGC CCC7IMCCT TCTCTCACCC ACAGCACAGG GCACTGGGAA AATGCCCAAT GAGTCCTGCC TCTGGGTFGT GCI=GGACT n7~CAGTGTG TCTCGCATCC ACTCrrCAAC TTIGAATGTrG CAACAGCCAT GAAAAAAGAA ATGCAAAGCG ATTCAGGATG AGAGCAATAC CCTACTCCAA AGAAGGCAAC ATAGAAGCTC AGAGAGATCA AGCAA'IMGC CCAAGACCAC ACAGCTAGGA GTGGAACTCA TGGCTGTCCA AGCCCCATGC CTCTGCTGAA GGTAGAGATG AAT7ACAGCA ACAAGTCTAG AAAGGTGCCT GCCCTATGGT CTGTGAGTCT TGCCTAAGAA TGAAAGAGGA GCCAGTGGGT TAAAGATGAG GTCACCAACA ACGGTGGTGT TGGAG TrAC CACTGATAAT AAGGGTGCAA AATGTAAA'IT ACTAATGTITT ATrGAGCCTA GTGCAGTGCG TGGGGCATIT TGCACATTGT CTCTGATCCC TATGACAACC WO 00/09525 PCT/US99/1 7712 EPI-109 29 CTGAGAGGTA GTGG'TF[AA CTGCCATGTT ACAGGTGAGG TCATTGTGGT TCAAGGACGT TAAGTAACTr CCCCAGCGTG ACACGGCflA TAAGTAAGGC AGCCAGGATG TGAACCCAGT AGGACTATCT GGCTGCAAAG TCCCCACCCC CCTCGCCATC TGTATCCTCC kATCACTCA GTG='~GCT GCATAGAAGG TAACGGAAAT CACGATGCCA CAGACTGTCC AGGAAGACAG AAACTAGGCA GATGGGC TGG CCATGGTCTC CAAGCCAGAC TGGAATCTCC AGGTCTGGAA TGATATCATT =ICTCflT AATAAA TAA CTCACCCACC ACACGGC1TI GAGAGGCTCA AAGrrGACCA ACTCCCT7GG GAGGGCCCCG GT7GATAAGG AAGGAACGTG AATCCTCCCA TCACGGAAGC 'FFCAAGGAGG TCAAGGGTCC AACACTI7GAG ATTGTTAGTG CTGTTGGTGG ATACTGGCCA AGGAAATATC CCAGTGGAGC CTCGAGATGA AGAACATGAG GCCCCCGTr7 AGAACCAAGG ATCAGAGGGG GCTCTGTAAG ACCCAGGGGA GTCAGGTGCA CTGGAGCGCG GGCATGCAGA AAACAGCCTG AGCTCCACCT CGGCTL'CTCC TTrGTCCTGGC TGGTrGTCCT TAACCCCTGT CTCCTTCTGG ACCAGT1T= GTCCITCCCT TGTGACCGCT GAGGGGTAAC AGCCTC'TrC CAcCT r CAGCGCCGAC ATGCTCAATG TCACCTGCA AGGGCCCACT CTAACGGGA CCMTGCCCA GAGCAAATGC CCCCAAGTGG AGTGGCTGGG CTGGCTCAAC ACCATCCAGC CCCCCTFCCT CTGGGTGCTG TTCGTGCTGG CCACCCTAGA GAACATCF= GTCCTCAGCG T=TCTGCCT GCACAAGAGC AGCTGCACGG TGGCAGAGAT CTACCTGGGG AACCTGGCCG CAGCAGACCT GATCCTGGCC TGCGGGCTGC CCTTCTGGGC CATCACCATC TCCAACAACT TCGACTGGCT C=~GGGGAG ACGCTCTGCC GCGTGGTGAA TGCCATTATC TCCATGAACC TGTACAGCAG CATCTGTIT7C CTGATGCTGG TGAGCATCGA CCGCTACCTG GCCCTGGTGA AAACCATGTC CATGGGCCGG ATGCGCGGCG TGCGCTGGGC CAAGCTCTAC AGCT7GGTGA TCTGGGGGTG TACGCTGCTC CTGAGCTCAC CCATGCTGGT G1TCCGGACC ATGAAGGAGT ACAGCGATGA GGGCCACAAC GTCACCG=T GTGTCATCAG CTACCCATCC CTCATCTGGG AAGTGTTCAC CAACATGCTC CTGAATGTCG TGGGCTCCT GCTGCCCCTG AGTGTCATCA CCTrCTGCAC GATGCAGATC ATGCAGGTGC TGCGGAACAA CGAGATGCAG AAGT'FCAAGG AGATCCAGAC GGAGAGGAGG GCCACGGTGC TAGTCCTGGT TGTGCTGCTG CTAY7CATCA TCTGCTGGCT GCCCTTCCAG ATCAGCACCT TCCTGGATAC GCTGCATCGC CTCGGCATCC TCTCCAGCTG CCAGGACGAG CGCATCATCG ATGTAATCAC ACAGATCGCC TC=TCATGG CCTACAGCAA CAGCTGCCTC AACCCACTGG TGTACGTGAT CGTGGGCAAG CGCTTCCGAA AGAAGTC'ITG GGAGGTGTAC CAGGGAGTGT GCCAGAAAGG GGGCTGCAGG TCAGAACCCA 'FrCAGATGGA GAACTCCATG GGCACACTGC GGACCTCCAT CTCCGTGGAA CGCCAGATrC ACAAACTGCA GGACTGGGCA GGGAGCAGAC AGTGAGCAAA CGCCAGCAGG GCTGCTGTGA ATTTGTGTAA GGATITGAGGG ACAG'TGCTT TrCAGCATGG GCCCAGGAAT GCCAAGGAGA CATCTATGCA CGACCTGGG AAATGAGI1'G ATGTCTCCGG TAAAACACCG GAGACTAAYI' CCTGCCCTGC CCAATIIGC AGGGAGCATG GCTGTGAGGA TGGGGTGAAC TCACGCACAG CCAAGGACTC CAAAATCACA ACAGCATTAC TGrrCTrAT'r TGCTGCCACA CCTGAGCCAG CCTGCTCCT CCCAGGAGTG GAGGAGGCCT GGGGGCAGGG AGAGGAGTGA CTGAGCTCC CTCCCGTGTG TrCTCCGTCC CTGCCCCAGC AAGACAACTT AGATCTCCAG GAGAACTGCC ATCCAGC1T GGTGCAATGG CTGAGTGCAC AAGTGAGTTG T-FGCCCTGGG 1TrCMAAT CTAT17CAGCT AGAACM~GA AGGACAAM~ CffGCA'FrAA TAAAGGTTAA GCCCTGAGGG GTCCCTGATA ACAACCTGGA GACCAGGATT 'FrATGGCTCC CCTCACTGAT GGACAAGGAG GTCTGTGCCA AAGAAGAATC CAATAAGCAC ATATGAGCA CTrGCTGTAT ATGCAGTATr GAGCACTGTA GGCAAGAGGG AAGAAAGAGA AGGAGCCATC TCCATCTGA AGGAACTCAA AGACTCAAGT GGGAACGACT GGGCACTGCC ACCACCAGAA AGCTGTTCGA TGAGACGGTC GAGCAGGGTG CTGTGGGTGA TATGGACAGC AGAAGGGGGA GCCAGGTFTCC AcJCTCACCAA TACTATI'GCA CACCACCTGT CCTGCCTC CTGCAGAAAA CAGCCTGAGC TCCACCTCGG CTrCTCCTrG CCCTGGCTGG TJTGTCCTL'AA CCCCTGTCTC CTTCTGGACC AGTTITGTC CTTrCC=rGT GACCCTGAGG GGTAACAGCC TCYITCCAC TIT7CMTCAG CGCCGACATG CTCAATGTCA CCTTGCAAGG GCCCACTC'F[ AACGGGACCT FrGCCCAGAG CAAATGCCCC CAAGTGGAGT GGCTGGGCTG GCTCAACACC ATCCAGCCCC CCYTCCTCTG GGTGCTGI'TC GTGCTGGCCA CCCTAGAGAA CATCMFGTC CTCAGCGTCT TCTGCCTGCA CAAGAGCAGC TGCACGGTGG CAGAGATCTA CCTGGGGAAC CTGGCCGCAG CAGACCTGAT CCTGGCCTGC GGGCTGCCCT TCTGGGCCAT CACCATCTCC AACAACTrFCG ACTGGCT=T TGGGGAGACG CTCTGCCGCG TGGTGAATGC CATTATCTCC ATGAACCTGT ACAGCAGCAT CTG=TCCTG ATGCTGGTGA GCATCGACCG CTACCTGGCC CTGGTGAAAA CCATGTCCAT GGGCCGGATG CGCGGCGTGC GCTGGGCCAA GCTCTACAGC TT1GGTGATCT GGGGGTGTAC GCTGCTCCTG AGCTCACCCA TGCTGGTGTI' CCGGACCATG AAGGAGTACA GCGATGAGGG CCACAACGTC ACCGCTGTG TCATCAGCTA CCCATCCCTC ATCTGGGAAG TGTlCACCAA CATGCTCCTG AATGTCGTGG G=TCCTGCT GCCCCTGAGT GTCATCACCT TCTGCACGAT GCAGATCATG CAGGTGCTGC GGAACAACGA GATGCAGAAG TrCAAGGAGA TCCAGACGGA GAGGAGGGCC ACGGTGCTAG TCCTGGTITGT GCTGCTGCTA ITCATCATCT GCTGGCTGCC CTICCAGATC AGCACC=CC TGGATACGCT GCATCGCCTC GGCATCCTCT CCAGCTGCCA GGACGAGCGC ATCATCGATG TAATCACACA GATCGCCTCC TTCATGGCCT ACAGCAACAG CTGCCTCAAC CCACTGGTGT ACGTGATCGT GGGCAAGCGC 'TCCGAAAGA AGT=~GGGA GGTGTACCAG GGAGTGTGCC AGAAAGGGGG CTGCAGGTCA GAACCCATTC AGATGGAGAA CTCCATGGGC ACACTGCGGA CCTCCATCTC CGTGGAACGC CAGAITCACA AACTGCAGGA CTGGGCAGGG AGCAGACAGT GAGCAAACGC CAGCAGGGCT GCTGTGAATF TGTGTAAGGA TTGAGGGACA G'ITGCT=TC AGCATGGGCC CAGGAATGCC AAGGAGACAT CrATGCACGA CCT7GGGAAA TGAGTTGATG TCTCCGGTAA AACACCGGAG ACTAAT~rCCT GNCCTrGCCCA AYITGCAGG GAGCATGGCT G3TGAGGATGG GGTGAACTCA CGCACAGCCA AGGACTCCAA AATCACAACA GCATTACTrGT TCTTrATIGC TGCCACACCT GAGCCAGCCT GCTCC'ICCC AGGAGTGGAG GAGGCCTGGG GGCAGGGAGA GGAGTGACTG AGCTTCCCTC CCGTGTGrC TCCGTCCCTG CCCCAGCAAG ACAACTTAGA TCTCCAGGAG AACTGCCATC CAGCMTGGT GCAATGGCTG AGTGCACAAG TGAGTTG17G CCCTGGGTIT7 CIAATCTA TTCAGCTAGA AC=hNAAGG ACAAT1~cITT GCATTAATAA. AGc3TTAAGCC CTGAGGGGTC CCTGATAACA ACCTGGAGAC CAGGA=I~A TGGCTCCCCT CACTGATGGA CAAGGGAGGT CTGTGCCAAA GAAGAATCCA ATAAGCACAT ATTGAGCACT TGCTGTATAT GCAGTA7TGA GCACTGTAGG CAAGAGGGAA GAAAGAGAAG GAGCCATCTC CATCT-TGAAG GAACTCAAAG ACTCAAGTGG GAACGACTGG CACTGCCACC ACCAGAAAGC TGT-TCGACGA GACGGTCGAG CAGGGTGCTG TGGGTGATAT GGACAGCAGA AGGGGGAGAC CAAGGTTCCA WO 00/09525 PCT/US99/17712 EPI-109 30 GCTCAACCAA TAACTATTGC ACAACCACCT GTCCCTGCCT CAGTTCCCTC TfCTGTAACA TGAAGTCGTT GTGAGGGTTA AAGGCAGTAA CAGGTATAAA GTACTTAGAA AAGCAAAGGG TGCTACGTAC ATGTGAGGCA TCATTACGCA GACGTAACTG GGATATGTTT ACTATAAGGA AAAGACACTG AGGTCTAGA TGATCCTATC ACAACCTGAG AGTAGT-I i ACTCCATTTA CAGGTGAGGT CATrGTGGTT CAAGGACGT[ AAGTAACTTC CCCAGCTCAC ACGGCTTATA AGTAAGGCAG CCAGGATGTG AACCCAGTAG GACTATCTGG CTGCAAAGTC CCCACCCTCC CTCGCCATCT GTATCCTCCA ATCATCTTCA GTGCTTTGCT GATAGAAGGT ACGGAAATAC GATGCCACAG ACTGTCCAGG AAGACAGAAA CTAGGCAGAT GGGCTGGCCA TGGTCTCCAA GCCAGACTGG AATCTCCAGG TCTGGAATGA TATCATTr CTCTh-1AAT AAATrAACTC ACCCACCACA CGGCTTGAG AGGCTCAAAG GTGACCAACT CCCTTGGGAG GGCCCCGGTT GATAAGGAAG GAATGTGAAT CCTCCCATCA CGGAAGCT7C AAGGAGGTCA AGGGTCCAAC ACTTGAGATT GTTAGTGCTG TTGGTGGATA CTGCAGAATA TCCAGTGGAG CCTCAGATGA AGAACATGAG GCCCCGITA GATCCAAGGA TCAGAGGGGG CTCTGTAAGA CCCAGGGGAG TCAGGTGCAC TGGAGCGCGG GCTGCAGAAA ACAGCCTGAG CTCCACCTCG GCTTCTCCTT GCCCTGGCTG GTTGTCCTTA ACCCCTGTCT CCTTCTGGAC CAGTTTGT CCTTCCCTTG TGACCTGAGG GGTAACAGCC TC1111CCAC TTrCTrTCAG CGCCGACATG CTCAATGTCA CCTTGCAAGG GCCCACTTT AACGGGACCT TTGCCCAGAG CAAATGCCCC CAAGTGGAGT GGCTGGGCTG GCTCAACACC ATCCAGCCCC CCTTCCTCTG GGTGCTGTTC GTGCTGGCCA CCCTAGAGAA CATCTGTC CTCAGCGTCT TCTGCCTGCA CAAGAGCAGC TGCACGGTGG CAGAGATCTA CCTGGGGAAC CTGGCCGCAG CAGACCTGAT CCTGGCCTGC GGGCTGCCCT TCTGGGCCAT CACCATCTCC AACAACTTCG ACTGGCTCTr TGGGGAGACG CTCTGCCGCG TGGTGAATGC CATTATCTCC ATGAACCTGT ACAGCAGCAT CTGTTTCCTG ATGCTGGTGA GCATCGACCG CTACCTGGCC CTGGTGAAAA CCATGTCCAT GGGCCGGATG CGCGGCGTGC GCTGGGCCAA GCTCTACAGC TTGGTGATCT GGGGGTGTAC GCTGCTCCTG AGCTCACCCA TGCTGGTGTT CCGGACCATG AAGGAGTACA GCGATGAGGG CCACAACGTC ACCGCTTGTG TCATCAGCTA CCCATCCCTC ATCTGGGAAG TGTrCACCAA CATGCTCCTG AATGTCGTGG GCTTCCTGCT GCCCCTGAGT GTCATCACCT TCTGCACGAT GCAGATCATG CAGGTGCTGC GGAACAACGA GATGCAGAAG TTCAAGGAGA TCCAGACGGA GAGGAGGGCC ACGGTGCTAG TCCTGGTGT GCTGCTGCTA TTCATCATCT GCTGGCTGCC CTTCCAGATC AGCACCTTCC TGGATACGCT GCATCGCCTC GGCATCCTCT CCAGCTGCCA GGACGAGCGC ATCATCGATG TAATCACACA GATCGCCTCC TTCATGGCCT ACAGCAACAG CTGCCTCAAC CCACTGGTGT ACGTGATCGT GGGCAAGCGC TTCCGAAAGA AGTCTTGGGA GGTGTACCAG GGAGTGTGCC AGAAAGGGGG CTGCAGGTCA GAACCCATTC AGATGGAGAA CTCCATGGGC ACACTGCGGA CCTCCATCTC CGTGGAACGC CAGATTCACA AACTGCAGGA CTGGGCAGGG AGCAGACAGT GAGCAAACGC CAGCAGGGCT GCTGTGAATT TGTGTAAGGA TTGAGGGACA GTTGCTTFTC AGCATGGGCC CAGGAATGCC AAGGAGACAT CTATGCACGA CCTTGGGAAA TGAGTGTTGA TGTCTCCGGT AAAACACCGG AGACTAATrC CTGCCCTGCC CAATTTTCGA GGGAGCATGG CTGTGAGGAT GGGGTGAACT CACGCACAGC CAAGGACTCC AAAATCACAA CAGCATTACT GTCT'A1TTT GCTGCCACAC CTGAGCCAGC CTGCTCCTTC CCAGGAGTGG AGGAGGCCTG GGGGAGGGAG AGGAGTGACT GAGCTTCCCT CCCGTGTGTT CTCCGTCCCT GCCCCAGCAA GACAACTTAG ATCTCCAGGA GAACTGCCAT CCACGTTTGG TGCAATGGCT GAGTGCACAA GTGAGTTGTT GCCCTGGGTT TCTTAATCT ATCAGCTAGA ACTrTGAAGG ACAATTCTT GCATTAATAA AGGTTAAGCC CTGAGGGGTC CCTTGATAAC AACCTGGAGA CCAGGATT ATGGCTCCCC TCACTGATGG ACAAGGAGGT CTGTGCCAAA GAAGAATCAA TAAGCACATA TGAGCACTTC TGTATATCAG TATTGAGCAC TGTAGGCA ATGTTCTCTC CCTGGAAGAT ATCAATGTTT CTGTCTGTTT GTGAGGACTC CGTGCCCACC ACGGCCTCTT TCAGCGCCGA CATGCTCAAT GTCACCTTGC AAGGGCCCAC TCTTAACGGG ACCTGCCC AGAGCAAATG CCCCCAAGTG GAGTGGCTGG GCTGGCTCAA CACCATCCAG CCCCCCTTCC TCTGGGTGCT GTTCGTGCTG GCCACCCTAG AGAACATCTr TGTCCTCAGC GTCTTCTGCC TGCACAAGAG CAGCTGCACG GTGGCAGAGA TCTACCTGGG GAACCTGGCC GCAGCAGACC TGATCCTGGC CTGCGGGCTG CCCTTCTGGG CCATCACCAT CTCCAACAAC TTCGACTGGC TCTTTGGGGA GACGCTCTGC CGCGTGGTGA ATGCCATTAT CTCCATGAAC CTGTACAGCA GCATCTGTTT CCTGATGCTG GTGAGCATCG ACCGCTACCT GGCCCTGGTG AAAACCATGT CCATGGGCCG GATGCGCGGC GTGCGCTGGG CCAAGCTCTA CAGCTTGGTG ATCTGGGGGT GTACGCTGCT CCTGAGCTCA CCCATGCTGG TGTTCCGGAC CATGAAGGAG TACAGCGATG AGGGCCACAA CGTCACCGCT TGTGTCATCA GCTACCCATC CCTCATCTGG GAAGTGTTCA CCAACATGCT CCTGAATGTC GTGGGCTTCC TGCTGCCCCT GAGTGTCATC ACCTTCTGCA CGATGCAGAT CATGCAGGTG CTGCGGAACA ACGAGATGCA GAAGTTrCAAG GAGATCCAGA CGGAGAGGAG GGCCACGGTG CTAGTCCTGG TTGTGCTGCT GCTATTCATC ATCTGCTGGC TGCCCTTCCA GATCAGCACC TTCCTGGATA CGCTGCATCG CCTCGGCATC CTCTCCAGCT GCCAGGACGA GCGCATCATC GATGTAATCA CACAGATCGC CTCCTCATG GCCTACAGCA ACAGCTGCCT CAACCCACTG GTGTACGTGA TCGTGGGCAA GCGCTTCCGA AAGAAGTCTT GGGAGGTGTA CCAGGGAGTG TGCCAGAAAG GGGGCTGCAG GTCAGAACCC ATTCAGATGG AGAACTCCAT GGGCACACTG CGGACCTCCA TCTCCGTGGA ACGCCAGATT CACAAACTGC AGGACTGGGC AGGGAGCAGA CAGTGAGCAA ACGCCAGCAG GGCTGCTGTG AATTTGTGTA AGGATTGAGG GACAGTTGCT T ATGTTCTCTC CCTGGAAGAT ATCAATGTTT CTGTCTGTTC GTGAGGACTC CGTGCCCACC ACGGCCTCTT TCAGCGCCGA CATGCTCAAT GTCACCTTGC AAGGGCCCAC TCTrAACGGG ACCTTGCCC AGAGCAAATG CCCCCAAGTG GAGTGGCTGG GCTGGCTCAA CACCATCCAG CCCCCCTTCC TCTGGGTGCT GTTCGTGCTG GCCACCCTAG AGAACATCTT TGTCCTCAGC GTCTTCTGCC TGCACAAGAG CAGCTGCACG GTGGCAGAGA TCTACCTGGG GAACCTGGCC GCAGCAGACC TGATCCTGGC CTGCGGGCTG CCCTCTGGG CCATCACCAT CTCCAACAAC TTCGACTGGC TCTTTGGGGA GACGCTCTGC CGCGTGGTGA ATGCCATTAT CTCCATGAAC CTGTACAGCA GCATCTGTT CCTGATGCTG GTGAGCATCG ACCGCTACCT GGCCCTGGTG AAAACCATGT CCATGGGCCG GATGCGCGGC GTGCGCTGGG CCAAGCTCTA CAGCTTGGTG ATCTGGGGGT GTACGCTGCT CCTGAGCTCA CCCATGCTGG TGTrCCGGAC CATGAAGGAG TACAGCGATG AGGGCCACAA CGTCACCGCT TGTGTCATCA GCTACCCATC CCTCATCTGG GAAGTGTTCA CCAACATGCT CCTGAATGTC GTGGGCTTCC TGCTGCCCCT GAGTGTCATC ACCTTCTGCA CGATGCAGAT CATGCAGGTG CTGCGGAACA ACGAGATGCA GAAGTTCAAG GAGATCCAGA CGGAGAGGAG WO 00/09525 PCT/US99/17712 EPI-109 31 GGCCACGGTG CTAGTCCTGG TTGTGCTGCT GCTATTCATC ATCTGCTGGC TGCCCTTCCA GATCAGCACC TTCCTGGATA CGCTGCATCG CCTCGGCATC CTCTCCAGCT GCCAGGACGA GCGCATCATC GATGTAATCA CACAGATCGC CTCCTTCATG GCCTACAGCA ACAGCTGCCT CAACCCACTG GTGTACGTGA TCGTGGGCAA GCGCTTCCGA AAGAAGTCTT GGGAGGTGTA CCAGGGAGTG TGCCAGAAAG GGGGCTGCAG GTCAGAACCC ATTCAGATGG AGAACTCCAT GGGCACACTG CGGACCTCCA TCTCCGTGGA ACGCCAGATT CACAAACTGC AGGACTGGGC AGGGAGCAGA CAGTGAGCAA ACGCCAGCAG GGCTGCTGTG AATTTGTGTA AGGATTGAGG GACAGTrGCT T GCCCTTCAAA GATGAGCTGT TCCCGCCGCC ACTCCAGCTC TGGCTTCTGG GCTCCGAGGA GGGGTGGGGA CGGTGGGGAC ATCAGGCTGC CCCGCAGTAC CAGGGAGCGA CTGAAGTGCC CATGCCGCTT GCTCCGGAGA AGGTGGGTGC CGGGCAGGGG CTGCTCCAGC CGCCTCACCT CTGCTGGGAG GACAAACTGT CCCAGCACAG AGGGAGGGAG GGAGGGCAGG CAGCGGGGAG AAGTTTCCCT GTGGTCGTGG GGAGTT GCCCTTCAAA GATGAGCTGT TCCCGCCGCC ACTCCAGCTC TGGCTTCTGG GCTCCGAGGA GGGGTGGGGA CGGTGGTGAC GGTGGGGACA TCAGGCTGCC CCGCAGTACC AGGGAGCGAC TGAAGTGCCC ATGCCGCTTG CTCCGGAGAA GGTGGGTGCC GGGCAGGGGC TGCTCCAGCC GCCTCACCTC TGCTGGGAGG ACAAACTGTC CCAGCACAGA GGGAGGGAGG GAGGGCAGGC AGCGGGGAGA AGTTTCCCTG TGGTCGTGGG GAGTT GAGCTCTTCA ATATITTAGT GAAAGCTATA GATGAGGCTC CATAGGGGAT AAAGCACAGA CACACCTTT CAGAGGGCTT GTGGACTCTG GGCAGCCTGT CCATAGACCT CTGTCCCCAA CTGGCAAGTC AGGAAACTCC AGATTAAGGA GCCCCAATGT GGTTGAACAG CCAGGTGCAC AGATGAGTCA ACCACACAGC CAGGCCAGGG AGGGCCTTCA CTCAAGAGCC TACAGCCAGT TCACAGCCAA GCCAGGGCTA GCGCCAGGCC ACCCATAAAC TGATCTGAGA CTCTGTTTCC CTGTCTCCAT GATGATGGGA TCAGGCTTGA TrGCTGGTTT GTAGGCTTGT TATGAATCAA GTCACAGGGA AGAGGAGCTG ATGGGCTGGG GGGACGTCCT CTGGCCCTCC TGTCTCTTCC CCAGATCCAC TGGGCCCACT CTTATCTGTT CTCTTCTGAA GGAAGGGTTT TAAGGCTTCA AAAAAAAATG =TFTGAAAGT CCCTGCCCTT TCCAGCTCCT ACCGTCTCAG CCCTGGGAGT GTAAAGTGCT GCAGATAGTT AGTAAGTCTr TGAGCAAAAC TGAGAAAGCC AGCCTGAGCC TTGACATGGG AGAAACCTCC GCCATACATC TCCGAAGAAA CGGCCGCGTG TCTCAGGGGA GCGCAAACAC CCGTACCCAG GAAACAGGAC AGCTTCTGCC ACTGTCGCCC TTGGGAGCCG TACGTGGCAT GACAAAGAAA TCCCAGGACT CCGCCTGCCC ACCTGGCCAC CCTCTGTTA CACCTTCCGC GTAAACGCCC ACTGTTTACA TCCAAAACTC AGACACAAAA TAACCACCTC AAGAAGATAA ATAATGATAA GAAATAAATG TTACGCGAGG CAAATTATT CACATGGGGC T7CCCAGGCC ACTTTGTGGT CAGCCGGGAG GGACGTIT"T GCCGTCCCAC GACTCCAACG GGCAGCCGGG CCTACGCAAA CATGGAAATC TTCCAAGAGC CTCCCTGGCC CCCAGGGCTC AGAGGGTGGC AGAGCGGAGA GCGAAGGTGG CCGCAGCCTT CCCGGCCCCA CAGCCAGCCT GGCTCCAGCT GGGCAGGAGT GCAGAGCTCA GCTGGAGGCG AGGGGGAAGT GCCCAGGAGG CTGATGACAT CACTACCCAG CCCTTCAAAG ATGAGCTGTr CCCGCCGCCA CTCCAGCTCT GGCTTCTGGG CTCCGAGGAG GGGTGGGGAC GGTGGTGACG GTGGGGACAT CAGGCTGCCC CGCAGTACCA GGGAGCGACT GAAGTGCCCA TGCCGCTTGC TCCGGAGAAG GTGGGTGCCG GGCAGGGGCT GCTCCAGCCG CCTCACCTCT GCTGGGAGGA CAAACTGTCC CAGCACAGAG GGAGGGAGGG AGGGCAGGCA GCGGGGAGAA GTTTCCCTGT GGTCGTGGGG AGTTGGGAAA AGTTCCCTTC CTTCCGGAGG GAGG GAATrCGGGA AAAAGTGAAG GTGTAAAAGC AGCACAAGTG CAATAAGAGA TATITCCTCA AATTTGCCTC AAGATGGAAA CCCTTTGCCT CAGGGCATCC TTTTGGCTGG CACTGGTTGG ATGTGTAATC AGTGATAATC CTGAGAGATA CAGCACAAAT CTAAGCAATC ATGTGGATGA 1TI7CACCACT TTTCGTGGCA CAGAGCTCAG CTTCCTGGTT ACCACTCATC AACCCACTAA TTGGTCCTA CCCAGCAATG GCTCAATGCA CAACTATTGC CCACAGCAGA CTAAAATTAC TTCAGCTTTC AAATACATrA ACACTGTGAT ATCTTGTACT ATTCATCG TGGGAATGGT GGGGAATGCA ACTCTGCTCA GGATCATTTA CCAGAACAAA TGTATGAGGA ATGGCCCCAA CGCGCTGATA GCCAGTCTTG CCCTTGGAGA CCTTATCTAT GTGGTCATTG ATCTCCCTAT CAATGTATTT AAGCTGCTGG CTGGGCGCTG GCCITGAT CACAATGACT TTGGCGTATT TCTTGCAAG CTGTTCCCCT TTGCAGAA GTCCTCGGTG GGGATCACCG TCCTCAACCT CTGCGCTCTT AGTGT-FGACA GGTACAGAGC AGTTGCCTCC TGGAGTCGTG TTCAGGGAAT TGGGATrCCT TrGGTAACTG CCATTGAAAT TGTCTCCATC TGGATCCTGT CCTATCCT GGCCATTCCT GAAGCGATTG GCTTCGTCAT GGTACCCITr GAATATAGGG GTGAACAGCA TAAAACCTGT ATGCTCAATG CCACATCAAA ATTCATGGAG TTCTACCAAG ATGTAAAGGA CTGGTGGCTC TTCGGGTTCT ATTCTGTAT GCCCT7GGTG TGCACTGCGA TCTCTACAC CCTCATGACT TGTGAGATGT TGAACAGAAG GAATGGCAGC TTGAGAATTG CCCTCAGTGA ACATCTTAAG CAGCGTCGAG AAGTGGCAAA AACAGTTC TGCTTGGTTG TAAiTliiGC TCTTGCTGG TrCCCTCTTC ATTTAAGCCG TATATTGAAG AAAACTGTGT ATAACGAGAT GGACAAGAAC CGATGTGAAT TACTAG'TT CTTACTGCTC ATGGATTACA TCGGTATTAA CTrGGCAACC ATGAATTCAT GTATAAACCC CATAGCTCTG TATITTGTGA GCAAGAAATT TAAAAATTGT TTCCAGTCAT GCCTCTGCTG CTGCTGTTAC CAGTCCAAAA GTCTGATGAC CTCGGTCCCC ATGAACGGAA CAAGCATCCA GTGGAAGAAC CACGATCAAA ACAACCACAA CACAGACCGG AGCAGCCATA AGGACAGCAT GAACTGACCA CCCTTAGAAG CACTCCTCGG TACTCCCATA ATCCTCTCGG AGAAAAAAAT CACAAGGCAA CTGTGAGTCC GGGAATCTCT TCTCTGATCC TTCTCCTFA ATTCACTCCC ACACCCAAGA AGAAATGCTr TCCAAAACCG CAAGGGTAGA CTGGTTATC CACCCACAAC ATCTACGAAT CGTACTTCTT TAATTGATCT AATTTACATA TTCTGCGTGT TGTATTCAGC ACTAAAAAAT GGTGGGAGCT GGGGGAGAAT GAAGACTGTT AAATGAAACC AGAAGGATAT TTACTACTTT TGCATGAAAA TAGAGCTTC AAGTACATGG CTAGCTITTA TGGCAGTTCT GGTGAATGTT CAATGGGAAC TGGTCACCAT GAAACTTTAG AGATTAACGA CAAGATTC TACITFIT1 AAGTGATTTT TTGTCCTTC AGCCAAACAC AATATGGGCT CAAGTCACTT TTATTrGAAA TGTCATGG TGCCAGTATC CCGAATTC GCCACCATGG AAACCCTTTG CCTCAGGGCA TCCTITTGGC TGGCACTGGT TGGATGTGTA ATCAGTGATA ATCCTGAGAG ATACAGCACA AATCTAAGCA ATCATGTGGA TGATTTCACC ACTTCGTG GCACAGAGCT CAGCTTCCTG GTTACCACTC ATCAACCCAC TAATTGGTC CTACCCAGCA ATGGCTCAAT GCACAACTAT TGCCCACAGC AGACTAAAAT TACTTCAGCT TTCAAATACA TTAACACTGT GATATCTTGT ACTATTCA TCGTGGGAAT GGTGGGGAAT GCAACTCTGC TCAGGATCAT TTACCAGAAC AAATGTATGA GGAATGGCCC CAACGCGCTG ATAGCCAGTC TTGCCCT7GG AGACCTTATC TATGTGGTCA WO 00/09525 PCT/US99/17712 EPI-109 32 TTGATCTCCC TATCAATGTA TTTAAGCTGC TGGCTGGGCG CTGGCCTTTT GATCACAATG ACTTrGGCGT ATTTCITGC AAGCTGTTCC CCTrTGCA GAAGTCCTCG GTGGGGATCA CCGTCCTCAA CCTCTGCGCT CTTAGTGTTG ACAGGTACAG AGCAGTGCC TCCTGGAGTC GTGTrCAGGG AATTGGGATT CCTGGTAA CTGCCATTGA AATTGCCTCC ATCTGGATCC TGTCCT=TAT CCTGGCCATT CCTGAAGCGA TTGGCTTCGT CATGGTACCC TTGAATATA GGGGTGGACA GCATAAAACC TGTATGCTCA ATGCCACATC AAAATTCATG GAGTTCTACC AAGATGTAAA GGACTGGTGG CTCTTCGGGT TCTATTTCTG TATGCCCTTG GTGTGCACTG CGATCTCTA CACCCTCATG ACTGGTGAGA TGTTGAACAG AAGGAATGGC AGCTTGAGAA TTGCCCTCAG TGAACATCTT AAGCAGCGTC GAGAAGTGGC AAAAACAGTT TrCTGCTTGG TTGTAATTTT TGCTCTTTGC TGGTTCCCTC TTCAITAAG CCGTATATTG AAGAAAACTG TGTATAACGA GATGGACAAG AACCGATGTG AATTACTAG TTCTTACTG CTCATGGATT ACATCGGTAT TAACTTGGCA ACCATGAATT CATGTATAAA CCCCATAGCT CTGTATTTG TGAGCAAGAA ATTTAAAAAT TGTTCCAGT CATGCCTCTG CTGCTGCTGT TACCAGTCCA AAAGTCTGAT GACCTCGGTC CCCATGAACG GAACAAGCAT CCAGTGGAAG AACCACGATC AAAACAACCA CAACACAGAC CGGAGCAGCC ATAAGGACAG CATGAACTGA CCACCCTTAG AAGCACTCCT GAATTCGGGA AAAAGTGAAG GTGTAAAAGC AGCACAAGTG CAATAAGAGA TATTTCCTCA AATTGCCTC AAGATGGAAA CCCTTTGCCT CAGGGCATCC 11TrGGCTGG CACTGGTTGG ATGTGTAATC AGTGATAATC CTGAGAGATA CAGCACAAAT CTAAGCAATC ATGTGGATGA TTTCACCACT 'TTTCGTGGCA CAGAGCTCAG CTTCCTGGTT ACCACTCATC AACCCACTAA TTTGGTCCTA CCCAGCAATG GCTCAATGCA CAACTATTGC CCACAGCAGA CTAAAATTAC TTCAGCTC AAATACATTA ACACTGTGAT ATCTTGTACT AITTTCATCG TGGGAATGGT GGGGAATGCA ACTCTGCTCA GGATCATTTA CCAGAACAAA TGTATGAGGA ATGGCCCCAA CGCGCTGATA GCCAGTCTTG CCCTTGGAGA CCTTATCTAT GTGGTCATTG ATCTCCCTAT CAATGTATTT AAGCTGCTGG CTGGGCGCTG GCCTTTTGAT CACAATGACT TTGGCGTATT TCTTGCAAG CTGTTCCCCT FTGCAGAA GTCCTCGGTG GGGATCACCG TCCTCAACCT CTGCGCTCTT AGTGTTGACA GGTACAGAGC AGTTGCCTCC TGGAGTCGTG TTCAGGGAAT TGGGATTCCT TrGGTAACTG CCATTGAAAT TGTCTCCATC TGGATCCTGT CCTTTATCCT GGCCATTCCT GAAGCGATTG GCTTCGTCAT GGTACCCIT GAATATAGGG GTGAACAGCA TAAAACCTGT ATGCTCAATG CCACATCAAA ATTCATGGAG TTCTACCAAG ATGTAAAGGA CTGGTGGCTC TTCGGGTTCT AT1CTGTAT GCCCTTGGTG TGCACTGCGA TCTTCTACAC CCTCATGACT TGTGAGATGT TGAACAGAAG GAATGGCAGC TTGAGAATTG CCCTCAGTGA ACATCTTAAG CAGCGTCGAG AAGTGGCAAA AACAGTTTC TGCTTGGTTG TAAI1T11GC TCT1TGCTGG TrCCCTCTTC ATAAGCCG TATATTGAAG AAAACTGTGT ATAACGAGAT GGACAAGAAC CGATGTGAAT TACTrAGTT CTTACTGCTC ATGGATTACA TCGGTATTAA CTTGGCAACC ATGAATTCAT GTATAAACCC CATAGCTCTG TATITTGTGA GCAAGAAATT TAAAAATTGT TTCCAGTCAT GCCTCTGCTG CTGCTGTTAC CAGTCCAAAA GTCTGATGAC CTCGGTCCCC ATGAACGGAA CAAGCATCCA GTGGAAGAAC CACGATCAAA ACAACCACAA CACAGACCGG AGCAGCCATA AGGACAGCAT GAACTGACCA CCCTTAGAAG CACTCCTCGG TACTCCCATA ATCCTCTCGG AGAAAAAAAT CACAAGGCAA CTGTGAGTCC GGGAATCTCT TCTCTGATCC TTCTTCCTTA ATTCACTCCC ACACCCAAGA AGAAATGCTT TCCAAAACCG CAAGGGTAGA CTGGTTTATC CACCCACAAC ATCTACGAAT CGTACT=T TAATTGATCT AATTTACATA TTCTGCGTGT TGTATrCAGC ACTAAAAAAT GGTGGGAGCT GGGGGAGAAT GAAGACTGTT AAATGAAACC AGAAGGATAT TTACTACTT TGCATGAAAA TAGAGCTTTC AAGTACATGG CTAGCITIA TGGCAGTTrCT GGTGAATGTT CAATGGGAAC TGGTCACCAT GAAACTTTAG AGATTAACGA CAAGA'TTC TACTITTTT' AAGTGATT TTTGTCCTTC AGCCAAACAC AATATGGGCT CAAGTCACTT rATTTGAAA TGTCATTTGG TGCCAGTATC CCGAATTC AACAAGAAAA GCGTITGGTAG CTCTGGTGAA TCCCAAAAGA ATGTGGCAGT TGCTAGCCAT GCTCCTGAAT ATGTATAAAC AGTACATCAT ATGACTAAGA GT'fTGACTTA GGGGTTAGAT TFrATGTGTT TGAACCCCAA ATTAGTTATT TAATAGTTGG CACCCCAAAA CAAGTTACTT AACCTCACTA AGGTTCAGTT TTCCTGTTTA TAAAATGTAG ATAGTGATAG TATGTACT ATAGGATTAT TGTGAAAAAT AAATGAAATA TCAGATAT TTAGGATAAC ACCTGGCATA TGTTTGGTAT TCAGAATTAG TTGCTGCTGT TTATTCTGC TCTCCCTTGC ATCCCACTT TCTAAGTTGT AAACTAAATA GTTGTACACA GATTGACAGA TTAAGAAAGG CTTGTGATTG TGCTAGACCT ATGCCTATGC CTCTGTCTCA CCAGATTCCA GGTGTATATG TGGAGGTGGG ATAGGGAGTG GAGTAAGTGG GTAAATATTA AATTGCCCAG TTGGGCACCA TCCTGAATAT TATCTCTAAA GAAAGAAGCA AAACCAGGCA CAGCTGATGG GTTAACCAGA TATGATACAG AAAACAT'1TC CTTCTGCT TTGGTTTTAA GCCTATATTT GAAGCCTTAG ATCTCTCCAG CACAGTAAGC ACCAGGAGTC CATGAAGAAG ATG GATCTTCATG TGGAATGACT GGTTTCATTC AATAGACTTA ATTCAGCAGT CTGTGGGGAA GAGCAAGGTA TGATAGAATG GTTCCTCAAG TGCTTCAGAT GTGAAGTGGG TTrAAATATA CTGTCCCTGT CTrCTTCAGA GTFTTGGTAA AGATAAAATA GGACACTCAT TTAAAAGCAA TCTTTGCAAA TGACAAGCCA CTATAGACAT TAATAGAGTT 'TrCATTTCCA GTATTATCAT TAATATCAGA TCCTGGAAGA AGGTTGAGCC TTGACCTAGA GCAAAAAAAC AGAAGAATTA GTAAAGGAAT CCTGGAGAAA GCCCCTGCTG TGTATTTAAA GGAGAAAGGG AGATCATGTT GGGAAATTAT AATATTAAAA GTAAACAAAA GCTAGGAAGT AAAATAAAAT AAATrATATG GCCTAGATCC CCATAAGTAA TGG'TTAACT TCTGCCTTCC TGTGTTCTGA GCCAGATTAG GGCACAGTAG AGAAAGAGGA GTCTCTGAAA ATGTTTCCAA TTTCGCTGGT. CAGACAGCGG ATCATCAGTG AATCAGATGA AAATTTGTGG ATTTATGCAC TAACTGATCA GCAGGAAATT AAACAAGAAA AGCGTTGGTA GCTCTGGTGA ATCCCAAAAG AATTTGGCAG T7GCTAGCCA TGCTCCTGAA TATGTATAAA CAGTACATCA TATGACTAAG AGTTTGACTT AGGGGTTAGA TTTTATGTGT TTGAACCCCA AATTAGTTAT TTAATAGTTG GCACCCCAAA ACAAGTTACT TAACCTCACT AAGATTCAGT TTTCCTGTTT ATAAAATGTA GATAGTGATA GTATGTACTT TATAGGATTA TTGTGAAAAA TAAATGAAAT ATCAGATTTA TTTAGGATAA CACCTGGCAT ATGTTTGGTA TTCAGTAATT AGTTGCTGCT Gli1ATTCT GCTCTCCCTT GCATCCCACT TTTCTAAGTT GTAAACTAAA TAGTTGTACA CAGATTGACA GATTAAGAAA GGCTTGTGAT TGTGCTAGAC CTATGCCTCT CTCTCACCAG ATTCCAGGTG TATATGTGGA GGTGGGATAG GGAGTGGAGT AAGTGGGTAA ATATTAAATT GCCCAGTTGG GCACCATCCT GAATATTATC TCTAAAGAAA GAAGCAAAAC CAGGCACAGC TGATGGGT7A ACCAGATATG ATACAGAAAA CATTTCCTTC TGCTTTGG TTTTAAGCCT ATAT'TTGAAG WO 00/09525 PCT/US99/17712 EPI-109 33 CCTTAGATCT CTCCAGCACA GTAAGCACCA GGAGTCCATG AAGAAGATGG CTCCTGCCAT GGAATCCCCT ACTCTACTGT GTGTAGCCTT ACTGTTCTTC GGTAAGTAGA GATTCAATTA CCCCTCCCAG GGAGGCCCAA ATGAATTTGG GGAGCAGCTG GGGTAGGAAC CTTTACTGTG GGTGGTGACT TTTTCTAGGA CATGTGCAAA CTATTGGGCA TTTCCCAGGG ACTCTGTAGT GGAGCCAAGC TAGAAAGCAG AGGCAAGTGG GCTGAGCAAC ACCTAAGGAG GAAGCCAGAC TGAAAGCTTG GTTCCTrGCA TTGCTCTGG CATCTTCCAG AGTGCAAATT TCCTACCAAG GTAATGAGGG TAGAGGAGAG AAAGAAGCTC TTTCTTCCCC TGATTCTCAT TCCTGAAAAG ACGGTTGGTC CTTAAAATTC CATGGATGTA GATCTTATCC CCACACCCAG ATTCTAGTCC TCTGGAGATA AAGAAGACTG CTGGACACTA ATGTATCCTC TCTGGACTTT TGCAGCTCCA GATGGCGTGT TAGCAGGTGA GTCCTCTGTT CTTGTTCCCT TGGTGTATCA ACATGTCTGG GCATTGCT CCTCTCACTA TTCTTCGT CCCATCACTT CTGCTTCTA ATGAGCATGA ATCTGTTCCT TGGCCAGACT ACTTTCCCTC TCCACCTTGC CTTGTCTTTC TTTTTCCC TGATTCATTG CATTCTCTCA AGTCATTCTC TCCTCTGTT TAGTCAATAA CCATGTCTGT TGCACATATA CATGTCTCAT TCTCTCTCCT AGACACTG GCATGATCTC GCTCAATAAT TACATTATTA T7ATTATTGC CATTTATAA TTGAGGATGC TGAAACTCAG TGATTTTCTG GTGGTTACAT GGCTAAGGAA CTGGATCA ACGTAAGTTC CTTGGATCTA AGTCCAGTTC TCTTCTGACT ATATCACCCT ITGTTATCA CCATGTATCT ACTTCITTGG TCTCTGTTCA AA TGCACT ACATCCCCTT GTTCCAGGAA GCCATTCAAG ACTGACTTTC TTAGTGCCTC TCACTACTTT CTGGAACTGA CATATGTTTT TCACTCTGTA TATACTTACA ATTAAATAGT CATAAATATT CAGAGCTTGG AGAAACCTTA TArTCATCC AGTCCAGTAA ATTTATCCAT CCATAATTCA CTCATTCATT CACATAATAA ATATTAATG TAACAATGGT TGAACATGGC AGACAGTGTT TCTACCTCAA AAGAGATFGC AGTCCTCATT TACAGATACT GAATTGAAAT TAACAGAAGT AGAGTGAGTC AGCTCAAATC ACATAGTGAA TTGGTTTCTT TG1TTAAA TCTCCTGCAT ATGTGTCCTG TCTTCTCCC TGTGTTGGGC GTTCCCTGGG GCACCAATAC TAATTCTCC TTCCCCTAGA AATCAAAACA GGGTCTTATC ACCAACAGAA TAAGGACAGG TTGACCACTG ATTGTCAGAA TATTGCTTCG TTTGTACTTT TAAGCCTAGA CAGTTCAA TGACTT11 TCTCTCTACA TGTCTTTTCA TATTTATC T'TCTGAAGT CCCTCAGAAA CCTAAGGTCT CCTTGAACCC TCCATGGAAT AGAATATA AAGGAGAGAA TGTGACTCTT ACATGTAATG GGAACAATIT CTTTGAAGTC AGTTCCACCA AATGGTTCCA CAATGGCAGC CTTTCAGAAG AGACAAATTC AAGTTTGAAT ATTGTGAATG CCAAATTTGA AGACAGTGGA GAATACAAAT GTCAGCACCA ACAAGTTAAT GAGAGTGAAC CTGTGTACCT GGAAGTCTTC AGTGGTAAGT TCCAGGGATA TGGAAATACA GATCTCTCAT GTGAGGGATG GCTCATCTGA AGATGGGAAA AAACAGGTTA TTCCAAGGGT TAGGACACCA GAGTGGGATT CAAGGCCTCT CA1TI11AAG ACCCCTGCAT TGGCTGGGCA CAGTGGCTCA CGCCTGTAAT CCCAGCACTT TGGGAGGCTG AGGCAGGTGG ATCACGAGGT CAGGAGATCG AGACCATCCG GCTAACATGG TGAAACCCCA TCTCTGCTAA AAAATATATA TATATAAAAT TAGCCGGGCG TAGTGGTGGG CACCTGTAGT CCCAGGTACT CGGGAGGCTG AGGCAGGAGA ATGGTGTGAA CCCAGGAGGT GGAGGTTGCA GTGAGCTGAG ATCACGCCAC TGCCCTCCAG CCTGGGCTAC AGAGCAAGAC TCCGTCTCAA AAAATAAATA AATAAATAAA AAAGACCCCT GCATCTCTTT TCTTCTACCC CCTrCCCTTr TGATTACTTG TATGCCTTCT TTCAATATTC TAGTCATCTC TCAATATAT TCCTCCACCC TATTTTCCTC TATCTITCT GCCTAGATTC AGGTATATAT TATGTGGTCA AACAGCATGA CATATATGTG AACATTTCAA AGAGCTGTGT ATCTGGAATA GGATCAAAAG GTTTGACTTA AAGTTTGCT CTGCATAATC CATATGGCAG GACCTGAATA TTAGGTTGTA CTCTTCGTTA TGAAACATAT CTGGGTACAT TTCCTTATGT CCTCTGTTGT TACTTAAGAA CACATATTTC ATGCTTGTTT CA111-1ATC ACTCCTACTG CCAACAAATA GCATAGCATG CTTAGGCACA TGTGGCTTAA TTAGCAAATG TrGAATAAAC AAATTAATGA TTTTGAATAG TGACCAATAG GTCTC111TA TACTCTATAT TTTTCTCTTG AGTGAAAAAA AATGTTTCAA CCTCCATATG TAAATTCCAA ACACAAACTA AAGCAATGTA GAATAGCTTC TTTATTCCCT GGAGTAGGT-T CTAGAGAAGT CCTAAAGGAT TGGTCCTAAA TTAATTATGC TTATTATGCT AGCGATATTT CCTCAAAA TTCTCCTA ATGAATGCTT TAATTT ACAAAAGCAT TAACCATAGA ATGTGATTCT TGTCTTTCAC TGACTCA1A GTGACAAATA TGTTGAGT ACCTACCAAC TCCTAAGTAT TGCTACCAAC TCCTAAATAC TGTGTTGGGC ATTCAGAATA GAATGTAGAA CTAGACAGGG TCCCTGACTT CTTGGAGCAC AGAGCAGTAT GGGAAGAGGA CATTAAATAA AGAATTACAT AAGTAATTAA TTTAAATTAT ACATGTTG AAGAAGTTTT 1T1GACAA CTATAATTAA CACTAGAACT GGGAAGTwTTC TATAAGGTAA GAGAGGACAA AATAGACACT CTCCTAAGCT AAAATTCCCA AGAAAGACTG TTTATITCC CCTAACTAAC TAGAACTAGC AACAGAAGAT CTGAAAGGAA TTCTGGCTT CAAGTGTTCC ATGTATGGAC TCATCAGGGA GGTCCGAGAG GCFTGTGGC CCCAGACTGA CTTTTCAGGA GGGGAAAGGA TTTATCAATA CACAAGACAG GCTCTAAGCA TTATITTGTG CCCTAAAA ATCCACTA TGAGCCAAAA AGTGAGTTAA TGATAATrCA TAGTCTGA CACATGCTCT ATGCGTGGCT CTCTITCTC TATTCATTCT CTCTCTCTTC ATTTATTGTT AAATAAATAA TGTAATGAAT GTTCTTCAGA CTGGCTGCTC CTTCAGGCCT CTGCTGAGGT GGTGATGGAG GGCCAGCCCC TCTTCCTCAG GTGCCATGGT TGGAGGAACT GGGATGTGTA CAAGGTGATC TATTATAAGG ATGGTGAAGC TCTCAAGTAC TGGTATGAGA ACCACAACAT CTCCATTACA AATGCCACAG TTGAAGACAG TGGAACCTAC TACTGTACGG GCAAAGTGTG GCAGCTGGAC TATGAGTCTG AGCCCCTCAA CATTACTGTA ATAAAAGGTG AGTTGGTAAA GGAAAGGAAA AGCATCCATA GCAGGGGAAG GAAGAGAGAA CTTCTGAGCC TGAGCAGTTG CAGCTrGTAG AAGGGGGGCA CCTGTGATAC ACTGGAAAGC CTACCAGACT TGCAATGAGG AGACCTGGGT GATAGTATAT ATCTCAATCT CTGTTCAAA GCCTTGACTT GTTAAATGGT GATAGTAATA CCTGCTTGCA CTATGAAATT TTATGAAGA TTAATGTGGT AATATTTGTG AAATGACTTT GTAAACTGTT AAGCACTACC CAAGCATAAC AGATTGTGAT TACTATTG ATCTCAAAGT CATCTGTTGC TCCTGGGGGA ACACTTATAT TTATCAAATT GAAAAAAAGT TTCAAAGTTG AATGAAGAAA GGATATAAAG AGCTTGAGGA GCCCATTCCA GCTTAGGAGG GCTGGGAAAG GAAACCAGCA AGTCAGTAAG CTGTGTGCCT GTGTATTGAG GGAGGAGGGA ATGGACTTGA TATGGAGAGG GTAGGGAGGT GGACTGCCTC TATGGCCTGT AAGAAAAACT GCTCTCTCCA AACTCTTAT AAGAGAGGGA GCCTGTGAAG TATTCACT TGAAGGAGAA AGTTAGACTT TTCCTTCACA CACTTGTAC ATAATAATGT TTAAAAAAGC ATGAGGTCAA AATACATAAT TAAGTCCTAG CAGTTCTCTG TTAACTAATT TGAGACTGAA GTGCTATGTA CTTGTCTCTA GGCTTCCAGT ATCTTCATCT GTAAAACAGA ATAITGGTC TAGATrCCAT WO 00/09525 PCTIUS99/17712 EPI-109 34 TAGAATCATT TGATAACTTA AAAAATATAT TGATGCTCAT GTCTCATTTC TTGAGArrCT GATrrAA'FrG G'TTGGGGTG CAGCCTGGGT ATACGTATIT TTCATAGGTC 'TrCACATAA TGGTAATGGG TAGCCAATAT TGAGAATCAC TTGTCTAGGT GATCI=AAA TGATI17CTGG ATGTAATATr CTGAGGCTCT ATAAMTGAG ACTAATCACA AAAATCGGTA CAGMTATAA ACAGACTAAC AGAACCACAA AATAATAGAA 'FrGcAAGGCA AMTAACTAG TGCAA T7CT TCAT1TGCC TAACAGGCAT GTAAGAAATG ATGAIrGA'Tr GAGTAATAGG CA FrGATGAC CCCTGTCCTC ACI=GTCCC =IICCACCC CTAATrATA TGTGAATrCT GGTCTTGTCA 'IMCGAATAA GGGGTIATC TTTCCTATrG TCTCCCCTC TGGGCACGGC ACACTGGCTA CTGGAGTTrAA GAGGAAATGC TrAGGACTCC CTGTGGCTCC AGGGAGCACC AACAGAGCAA CTCAACCTAG TG FrAATCTG AGTG=E1CT CTGTGCTrCT GGATGCCACA TCACGCTAAA AATGAAGGAC AAAGCTTGGT C'IrcCT=A GGGAGGATGA AACTCTGAAC CTCATI=r~C AGTITCCCAAG ATGAATI7ATG 'TrTCTCATrG CATCTGTGTT CCACTACAGC TCCGCGTGAG AAGTACTGGC TACAA'Trr TATCCCAT17G TTGGTGGTGA rrCTGTI-rGC TGTGGACACA GGATrATA TCTCAACTCA GCAGCAGGTC ACATITCTCT TGAAGATTAA GAGAACCAGG AAAGGCTTCA GACTrCTGAA CCCACATCCT AAGCCAAACC CCAAAAACAA CTGATATAAT TACTCAAGAA ATATTT7GCAA CATTAGT=~ n7~CCAGCAT CAGCAAT7GC TACTCAATTG TCAAACACAG C11TGCAATAT ACATAGAAAC GTCTGTGCTC AAGGATITAT AGAAATGCT CATrAAACTG AGTGAAACTG GTTA.AGTGGC ATGTAATAGT AAGTGCTCAA ITAACA'17GG FFGAATAAAT GAGAGAATGA ATAGATMCAT TT1ATTAGCAT T-FGTAAAAGA GATGT7CAAT TTCAATAAAA TAAATATAAA ACCATGTAAC AGAATGCTTC TGAGTATFCA AGGC'IGCTA G'TTGTTTGT TrGT=TCTA CTAAAGGCAA GGACCATGAA GTTCTAGA1T GGAAATGTCC TCTCTGACT ATTGCAAGTG CGATCTAGGA ATGAAAAGAC ATAGGAGGAT GCCAGTGAGG TGGATCAM T FATGCTTCT TCTTCAGC'Fr ACTAAATATG AA='~CAGT T=~GGCAGA ATCAGGGACA GTCTCAAGAC ATAGGACTCT CAGGATGAAG TAGAGTCCAG GA'FrCCTCTG TGATTG=FT GCCCCTCCCA AATrrATATC 'FrGAAC=AT GTCTGTATC TT!ATACAGC ACCTGAACCA AGCA=IrGG AGAAATTCCA GCTAATAATA ATAACCAAAA CCTCGGCTC TGAAAACAGT CCAGGACTGA ATAAGATCTT GGGCAAAAGA ACTAGACAGT TrGrTAT T~rCCCTIC ATFIATGTC TTCATCATAG TCATTGGAGG CTCAT~CTrC TTGTCATGGA GTAAATGGGA 'FrAAAG'rrC TACTAAGAGT CTCCAGCATC CTCCACCTGT CTACCACCGA GCATGGGCCT ATA'T7GAAG CC'rAGATCT CTCCAGCACA GTAAGCACCA GGAGTCCATG AAGAAGATGG CTCCTGCCAT GGAATCCCCT ACTCTACTGT GTGTAGCC'FF ACTGTT=C GCTCCAGATG GCGTGTTAGC AGTCCCI'CAG AAACCTAAGG TCTCC=GAA CCCTCCATGG AATAGAATAT TTAAAGGAGA GAATGTGACT CTACATGTA ATGGGAACAA TIT7CIGAA GTCAGflCCA CCAAATGGTr CCACAATGGC AGC='~CAG AAGAGACAAA FCAAG1TIG AATATTGTGA ATGCCAAAT TGAAGACAGT GGAGAATACA AATGTCAGCA CCAACAAGTT AATGAGAGTG AACCTrGTGTA CCTGGAAGTC TTCAGTGACT GGCTGCTCCT TCAGGCCTCT GCTGAGGTGG TGATGGAGGG CCAGCCCCTC TFFCCTCAGGT GCCATGGTTG GAGGAACTGG GATGTGTACA AGGTGATCTA TTATAAGGAT GGTGAAGCTC TCAAGTACTG GTATGAGAAC CACAACATCT CCATTACAAA TGCCACAGT7 GAAGACAGTG GAACCTACTA CTGTACGGGC AAAGTGTGGC AGCTGGACTA TGAGTCTGAG CCCCTrCAACA flACTGTAAT AAAAGCTCCG CGTGAGAAGT ACTGGCTACA ATITITATC CCATFTGT7GG TGGTGAT7CT G ITGCTGTG GACACAGGAT TATITATCTC AACTCAGCAG CAGGTCACAT TTCTCTrGAA GA'FrAAGAGA ACCAGGAAAG GCTrCAGACT TCTGAACCCA CATCCTAAGC CAAACCCCAA AAACAACTGA TATAATTACT CAAGAAATAT TTGCAACATT AGITFMrC CAGCATCAGC AA'FrGCTACT CAAITGTCAA ACACAGCTTG CAATATACAT AGAAACGTCT GTGCTCAAGG A'I=ATAGAA ATGC'FrCAT'T AAACTGAGTG AAACTGGTTA AGTGGCATGT AATAGTAAGT GCTCAAFI'AA CATTIGG'ITGA ATAAATGAGA GAATGAATAG ATTCATIrAT TAGCAMTGT AAAAGAGATG TrCAAITrCA ATAAAATAAA TATAAAACCA TGTAACAGAA TG=TCTGAG TAAAAAAAAA AAAAAAAAAA AAAAAAAA TCTCAATATA ATAATATTCT 'FfATTCCTGG ACAGCTCGGT TAATGAAAAA ATGGACACAG AAAGTAATAG GAGAGCAAAT CT7GCTCTCC CACAGGAGCC TrCCAGTGTG CCTGCATFTG AAGTC=GGA AATATCTCCC CAGGAAGTAT CTTCAGGCAG ACTATTGAAG TCGGCCTCAT CCCCACCACT GCATACATGG CITGACAGT[r TGAAAAAAGA GCAGGAGTrC CTGGGGGTAA CACAAATTCT GACTGCTATG ATATGCC'fl GTI=GGAAC AGTrGTCTGC TCTGTACTTG ATA'IMCACA CATFIGAGGGA GACATT CATCATIAA AGCAGGT7AT CCATrCTGGG GAGCCATATr TTITCTAT7 TCTGGAATGT TGTCAATITAT ATCTGAAAGG AGAAATGCAA CATATCTGGT GAGAGGAAGC CTGGGAGCAA ACACTGCCAG CAGCATAGCT GGGGGAACGG GAATTACCAT CCTGATCATC AACCTGAAGA AGAGCTTGGC CTATATCCAC ATCCACAGT7 GCCAGAAATr T1TGAGACC AAGTG=T1A TGG=TCCT7 TrCCACTGAA ATrGTAGTGA TGATGCTG'Fr TCTCACCATT CTGGGACTTG GTAGTGCTGT GTCACTCACA ATCTGTGGAG CTGGGGAAGA ACTCAAAGGA AACAAGG FrC CAGAGGATCG TG'TrATGAA GAA77AAACA TATA7FCAGC TACTF[ACAGT GAGTrGGAAG ACCCAGGGGA AATGTCTCCT CCCATTGAI7 TATAAGAATC ACGTGTCCAG AACACTCTGA 7rCACAGCCA AGGATCCAGA AGGCCAAGGT =~GTrAAGG GGCTACTGGA AAAA1TICTA TTCTCTCCAC AGCCTGCTGG =~l AAGCTI=CA AAGGTGCAAT TGGATAAC17 CTGCCATGAG AAATGGCTGA A TGGGACAC AAGTGGGGAC AATTCCAGAA GAAGGGCACA TCTCTICT TTCTGCAGTT CTIT7CTCACC 17rCAACTC CTACTAAAAT GTCTCAT1T CAGGTTCTGT AAATCCTGCT AGTCTCAGGC AAAAT7ATGC TCCAGGAGTC TCAAATFC, TATI-CATA TFAGTCTIA MTAGTAGAC TITCTCAA'FI YFCTATTCAT CACAAGTAAA AGCCTGTrGA T=TAATCAG CCAAGAAACT TATCTGTCTG GCAAATGACT TATGTATAAA GAGAATCATC AATGTCATGA GGTAACCCAT TrCAACTGCC TATTCAGAGC ATGCAGTAAG AGGAAATCCA CCAAGTCTCA ATATAATAAT Ar17=ATr CCTGGACAGC TCGGTTAATG AAAAAATGGA CACAGAAAGT AATAGGAGAG CAAATCT7GC TCTCCCACAG GAGCCTrCCA GGTAGGTACA AGGTATrA'Fr TI=CTACC CTCAGTCACT TGTGGCAGGG GAAGTCATAG TCACGGTGCT TAGGAGATGA AACTIATTG ATIT7AGGCAT GGATCCATCT AGTrAATTA ATATA17GGG TATGAGGAAG CTACTTGCTG TA='~CCAT GTGGTTCT CTCCCTGGAG AGGAACA'Tr7 TTACTCAGCT TGCAAACTGG AAATAGAMY TCTCACATFIA GAAGCTCATr I17CTGGGTAT GAGACAGGAG AGT7CATACT GTGTATGTAG ATCTCTGGCT TCTGGGTCTG ACATGTGCTG AGGGACACAT ATCCTTCACA CATGCrI=A TAAATA=~G ATAAAGTAAC CTGC==IG A FrGGTCTI ATAATCCATA AGCTGTGGGA TGCTICTCTG WO 00/09525 PCT/US99/17712 EPI-109 35 AAGATGAAAA TAGTAATAGA GTCCCATCTA GCTA FTCAAA GCCATrrCC-rr CATTGTATrC TGTGCACATG AAGiTGGGGT 'ITGTTACTGA CAAAATATAT TCAGATACAT TTCTATGTTA AAAGGATTGT GAGATGCATA GGTAAATGTG TI1AT1ICA GTITACT7G TCAACATAGA TGAATGAGAA AGAACTTGAA AGTAACACTG GATFAAGAAT AGGAAANTTT GGCATGGATT TTGCTCCATT T7GTCCCATC TAATCACI17G GATAGTGTTC AGGTGTrCTI' GGTCAGTTAC TTGGATGCTC TGAGCT17AG 'IMCTTGGTG AYI'ACAATGA AGAMTGAAT TACAGGATGG C1TGAAAAA ATAAACAAAA CTCCCC1TC TGTCTGTCGA GAATGTrGCA CAGGGAGT-rA CAGAATG~rC TCATGACTGA ATFrGCIT=A AATIT7CACAG TGTGCCTGCA T1GAAGTCT TGGAAATATC TCCCCAGGAA GTATCTrCAG GCAGACTATT GAAGTCGGCC TCATCCCCAC CACTGCATAC ATGGCTGACA GTT1GAAAA AAGAGCAGGA GI7CCTGGGG GTGAGTGAGC CTCCTCCAAC ITTTGAVITAGA GTAAGGGTlG GGTCTAGAAA AGAATAT7GA GTTGCATCAA CTGTTCCC AC~rGGA ITC ATGAGAGGTG TTAGGTCCT7 TAAAAAACAT GGTAGATAAA GAGTTGACAC TAACTGGGTC CTFIGGGAA GAGCCAGAAG CA~T7CCTCA TAAAGAC7= AAA'ITGCTAG GACGAGAATG GCCAACAGGA GTGAAGGAfl CATAACTFA TCTJACTA GATGTAAAGA ACAATTACTG ATGT7CAACA TGACTACATA CATAAAGGCG CATGGAGAAA AGTATTGGCC TTCCATGCAT TAGGTAGTGC TTGTATCAAT TCTATAGTG G~rAGGGTAT CCTGGAAAAT CTACGTGTG GATCAT17~CT CAGGACAGTC TAGGACACTA ACGCAG=IC TCATG TT7GG CT7CTArrAT TAAAAAATGA TACAATCTCG GGAAAATFF TITGATITC ATGAAATTCA TGTGTT=C TATAGGTAAC ACAAATTCTG ACTGCTATGA TATGC=1IG 'FF=GGAACA GTTGTCTGCT CTGTACTTGA TATTrCACAC ATrGAGGGAG ACAT1T1TC ATCA ITAAA GCAGGT7ATC CA'TTCTGGGG AGCCATATI7 GTGAGTATAT ATCTATAATT GT'CTGAAA TAACACTGAA CATAGGYF= TCTCT=CTC AGATCTAACC AGTTGMTAT TCCCAGTATT AAGATGATAT TTATAA'FrCT TAATrATAAA TATATGTGAG CATATATAAC ATAGATATGC TCATTAACAA CAACAAAAGA TrCITITAC AAYJTAACGGT GGGT-rAAACA TTFTAGCCCAC AGITIATCC CATGAGAAAC CTGAATCTAA TACAAGTTAA ATGACTTGCC TAAGGGCCAC TTGACTAATA GTAA'FFGAAC CTAAAC=fC AGAATCCAAC TCCAGGAACA TACTTCTAGC ACTATI'CATC AATAAAGTTA TATGATAAAT ACATACAACT 'FFATCTGTCA ACTAAAAATA ACAACAGAGG CTGGGCATGG TGGCTCACAC CCGTAATCCC AGCACTrTGG GAGGCTGAGG CAGGTGGATC ACCTGAGGTC AGGAGTTTGA GACCAGCCTG ACCAACATGG TGAAACCTCA TCTCTACTAA ATATAAAAAA TlAGCTGAGT GTGATAGTGC ATACCTGTAA TCCAGCTACT TAAGAGGCTG AGGCAGGAGG =~G'T7GAA CCTGGAAGGC AGAGGTTGCA GTGAGCTGAG ATrGTGCCAT TGCACTCCAG CCTGGGCAAT AAGTGCGAAC TCTGTCrCAA AATAATAATA ATAATAATAG AAAATAAAGT TGT=rCATG AAAAATGAGG AAAGAGATTG CTGGGGTGAG AAACATTAAG ATCAATGGGC ATATGGTGAC =TCTATGCC CTAGAAACTC T1TANGGTA '!ITCTCCTG GTATCTCT= TACNCATCGT TCTATCTGGA AAAATAGGTG GATGAGTGAG ATAATAACGG TATATACIT TrAAAGGTCT AATTGACATA TATAAATTGC AAGTATTFCA GATGTCAA Fr TGCTAACC= GACACACATA GACACACATG AAAACATCAC CACATwrAATA CAATGTATGT ATCCATCAT7 CCAAAAGCTT CCCTGTGTAT CITGTAACT CITCTTCCT CCCTCCACTC CT7GTCCTCT CGTrCCCAAG AAAACATTGA TCTGCTCCT GTGAATATAA ATrAACTTAC ATflT=AGA GCTTATATA AGTATGTTCT CTTACTGTr TGTCTTCCIT CGCTGCACAG T-rATITrrGAG AT7CTTCAAG 7rT= =l~ ATATCGATAC TTCATrCACA AGAATATATr TTAAT7CTAG ACTATGTCAC A F7GAC1TG TCGTCTGCTA AATC=TAGT GCTCAGATGA C=GTTrCAGG ACTCTCCTTG AACCTGTACC TCTGITrANAT TGAAAC7rGT CTCTACTGTC 7mTFr7C AAACACAGCT TATPAGGTGT CTCTCAACCC ATCAAACNCA CAATCTGAGT CTTAGGAGA 'FrGCTGAA T'F7GTGCTAT TGACTTATAT NTATATNAAA TNTGTAAATG 'IMGGTAAAA ATATCATCAT GTACNTITC ATAATrACGC TATNTNCACA TGATATATGT CAGACTCTGG AAATATGCAT GCCACAGACA CGTGTTTCT7 GCCTAAAGGG GCTGATGGAA GACNCACATA CNAATAGACG KITGCAGTAG AATGAGAGTG GTGGTCTAAN CAGTACATGT CCTGATGrrG CTCGGACAGT TACTACNCCA AGAGTACCCC CTGCATTGTC AGGG'FrAGCA TCTCCTGGAA GCCTCATGTA AATGAAGAAT 7rCATGCTCC ATCCAGGACC TAATGAATAA GAATCTGCAT M~AGCAAGA CCCTCATATG ATTCATATAC ACTITITF 'FTIflTTA GATGGAGTCT CACTCTTGTC GCCCAGGCTG GAGTGCAATG GCATGATCT-r GGCTCACTGC AACCrCTGCC TCCCGGGTTC AAGTGAT'TCT CCTGTCTCAG CCTCCCTAGT AGCTGGGACT ACAGGTGCAT GCCACAGTGG CTGGCTAAfl 'IMGTATITT TAGTAGAGAC AGGG'T17CAC CATITGGTC AGGCTGGTCT TGAACTCATG ACCTCCGGTG AT-rCCCCCGC CTCGGCT7CC CAAAGTGCTrG GGATTACAGA CATGAGCCAC CACACCCGCC 'FrATrCGTAT ACNCATrrAA T7CTGAGAAG CACTCTATAG AAAATAAGAA TAAGAAAATA TTrGGGCTCAC AGGTGACATT AATAAGTAAC TT7ATCGAGT ACCCCAAATT 'ITACCTATGT 'ITGGAAGATG GGGTTAAAAG GACACATTGA AAACAAGAAC TCATTGTGGC FTTITTCC TCCIT=GA ACAGTITCT A'ITTCTGGAA TGT7GTCAAT TATATCTGAA AGGAGAAATG CAACATATCT GGTGAGTwrGC CCGMTCTGT =TTGTCCAT CCTTGAAAAG ATAAGAAGAA CAGAGTITA AGAGTCTrAA GGGAAACACA T='~GTCTC CTATA'ITACT TGTGAATGTG GATATATGAT TIrGTrTCAA TCTATITGT GTCCTAAGGC TI1TGCAAC AGAAGTrGGA TATATCATTA GAAACATAAA 7rGTACCA77 TAACATACAT GAAGTI17ATG MFACCTTGA CG'rTCTrCTA AAAAGTGTCC TACACCGGCA 'TTGTCCTTGT AGGCATAITC ACATGATCAA ATAAAATAAT TAGTITCAA TTAAGGAGAA TA'T1'GAGGA AAGACCGTAC GTGT7CATGT GGTTCCTGAA GGCAGTCCAG TGAGAAAGTA ATATATGCTJ? CATTAAACAA TGCGGACATr TTCAGGGMf7 CCC'fTrAA CCAAAAT=G GAAGCAATGT GGAATTTACT GGATGCATCC AGCCCTGAAA TGAAGATAGG 'I=ATrGAAT GTGCCAGCAA GTGCAGGCCC AGGTCTGAGT GT CTCAT]7 KITATCAGGT GAGAGGAAGC CTGGGAGCAA ACACTGCCAG CAGCATAGCT GGGGGAACGG GAATTACCAT CCTGATCATC AACCTGAAGA AGAGC'FGGC CTATATCCAC ATCCACAGT-r GCCAGAAAITr =1IGAGACC AAGTGCITA TGGCTTCCT7 71rCCACTGTA TGTATTFIT '1GTGTGGG AAGACTAAGA 7ITCTGGGTCC TAATGTAAGT AAGAAGCCCT CTTCTCCTGT TCCATGAACA CCATCG'FP CTGTAACTTC TATTACACAG TATAGTGGTT CrGTAAGTTC ACACAGCCCA GGGAGATGCT GGCTGCCCAC TCCCCTCAAC CCAGGCAAAT TCCTCGGGGT TAAAGTrATC TACTGCAAGT GACGATCTCT GGG'TI=rCT GTGCCTGTGT 'FrGTGTGTGT GTGTGTGTGT GTGTGTGTGT GTATGTGTCA CT=AAAAGG ACTGGTCAGA TGGTAGGGAG ATGAAAACAG GAGATGCTAT AAGAAAATAA ACT-I=GGGG CGAATACCAA TGTGACT=1 TITGTIGTC A'Ir7GT-rGCT GTTCAATAGG WO 00/09525 PCT/US99/17712 EPI-109 36 AAATTGTAGT GATGATGCTG TTTCTCACCA TTCTGGGACT TGGTAGTGCT GTGTCACTCA CAATCTGTGG AGCTGGGGAA GAACTCAAAG GAAACAAGGT AGATAGAAGC CCGATATAAA ATCTTGAATG ACAGGYAAC GAATTGGAGC TATTCCTT AAAATATGGC CTGGG1111C TGAAACATTT CTrCCAGAAA ATAGTTrCTC CAAGTTAT TACTTGGTT TACAAATCTC ACATTAAAT CACATTAT ACCATAAGTA GCACACATTT CATAATATTC CTCTGAATGA GGGTTGGGAT AATAGGACTG ATATGTTAGA AATGCCTTAA AGTGTGTGGA GCATGAGAGA TGGATGTACA GAAGGCTTGT GAGGAAACCA CCCAGGTATC TGGCCTTGTT TTCTGCCCCA GAACTAGCCG CCTATTCCTG TTTCTGTTTT ATTCCTTTGT TTCTTGACTT TTCCTTTCCA ACTTGCTCTA AAACCTCAGT TTTCTTTCCT TrCTGATTCA TGACTACCAA ATGTrTCAC TTGCCTCACC CGTCCATTAC ACCTTTGATA AGAACCACCA GACCTTGTGC TCATGTACTT GCCCATGTCT GATGGAAGAA ACATACTCTC TCCATCTGTC CACTTTCCTG AGGCATTCAA GTCTAGCCAC CTTTAAAAT CACTCTCCTC CAGGCTGGGC ACGGTGTCAC GCCTGTAATC TCAGCACT GTGAGGCTGA GGAGGGCGGA TCACTTGAAG TCAGGAGTTC AAAACCAGCC TGGCCAAATG GCAAAACCAA ATCTTCTTCA ATTATAACCA AATCTTAAAC CAAATCTCTA CTAAAAAATA CAACAAAACA AAACAACAAC AACAAAAACA GAAAAGGAAA CATTAGCCCA GCGTGGTGGC AGGTACCTGA GGTTCCAGAT ACTTGGGAGG CTGAAGCAGG AGAATCGCTT GAGCCCAAGA GATGGAGGTT GCAGTGAGCC GAGATCATGC CACTGCACCA CAGCCAGGGT GACAGAGCCA TACTCCCAG CACATTGGGA GGCCAAAGCT GAAGAATAAT TTGAGGTGAG GAITGGAGA CCAGCCTGGC CAACATGGTG AAACTCCGTC TGTACTAAAA ATATAAAACT TAGTGGGGCA TGGGGGCACA CACCTGTAAT TTCAGCTACT TAGGAGGCTG AGGCAGGAGA ATTGCTTGAA CCCGGGAGGC GGAAGTTGCA GTGAGCCAAG ATCGTGGCCA CTGCACTCCA GCCTGGGTGA CATAGTGAGA TTCTGTCTCA AAAAAAATAA AAGAAATTTA AAAAATCACT CTCTTCCAAA GATAGATAAA TAAGACAGCA GATATACTAA GGAATAACCT CACCAACTTG TCATTGACTG ACATGATTTC ITFTGGCCCA CTTGGCCAGC TAGTCTGGTT TGGTTTTCTG GAAATGAAAG AAATAATCAG AGTTTAATGA CAGAGAGCGT GAGACCCAGA AAGACAAAAG TAGATGAGGT AAGTCTCTTG AGCGAGACTT CTAGGGATGG GAAATTGTG GTGATTGATA TGAAATGATT TTTCCCTTAT CAGGTTCCAG AGGATCGTGT TTATGAAGAA TTAAACATAT ATTCAGCTAC TTACAGTGAG TTGGAAGACC CAGGGGAAAT GTCTCCTCCC ATTGATTrAT AAGAATCACG TGTCCAGAAC ACTCTGATTC ACAGCCAAGG ATCCAGAAGG CCAAGGTTTT GTTAAGGGGC TACTGGAAAA ATTCTATrC TCTCCACAGC CTGCTGGTTT TACATTAGAT TTATTCGCCT GATAAGAATA =TITGTTTCT GCTGCTTCTG TCCACCTTAA TATGCTCCTT CTATTTGTAG ATATGATAGA CTCCTATTTT TCTTGTTA TATTATGACC ACACACATCT CTGCTGGAAA GTCAACATGT AGTAAGCAAG ATTTAACTGT TTGATTATAA CTGTGCAAAT ACAGAAAAAA AGAAGGCTGG CTGAAAGTTG AGTTAAACTT TGACAGTTTG ATAATATTTG GTTCTTAGGG 1TT1111111 TTTTAGCATT CTTAATAGTT ACAGTrGGGC ATGATTGTA CCATCCACCC ATACCCACAC AGTCACAGTC ACACACACAT ATGTATTACT TACACTATAT ATAACTTCCT ATGCAAATAT T7TACCACCA GTCAATAATA CA1T111GCC AAGACATGAA GTTTTATAAA GATCTGTATA ATTGCCTGAA TCACCAGCAC ATTCACTGAC ATGATATTAT TTGCAGATTG ACAAGTAGGA AGTGGGGAAC TITATTAAG TrACTCGTTG TCTGGGGAGG TAAATAGGTT AAAAACAGGG AAATTATAAG TGCAGAGATT AACATTTCAC AAATGTTTAG TGAAACATr GTGAAAAAAG AAGACTAAAT TAAGACCTGA GCTGAAATAA AGTGACGTGG AAATGGAAAT AATGGTTATA TCTAAAACAT GTAGAAAAAG AGTAACTGGT AGAT=TTGTT AACAAATrAA AGAATAAAGT TAGACAAGCA ACTGGTTGAC TAATACATTA AGCGTITGAG TCTAAGATGA AAGGAGAACA CTGGTTATGT TGATAGAATG ATAAAAAGGG TCGGGCGCGG AGGCTCACGC CTGTAATCCC AGCCCTTTGG GAGGCCGAGG TGGGCAGATC ACGAAGTCAG TAGTTGAGA CCAGCCTGGC CAACATAGTG AAACCCCGTC TCTACTAAAA ATACAAAAAA AAAATTAGCT GGGTGTGGTG GCAGTCACCT GTAGTCCCAG CTACTFGGGA GGATGAGGCA GGAGAATCGC T7GAACCTGG GAGGCGGAGG TTGCAGTGAG CCGAGATCGC ACCAGTGCAC TCCAGCCTTG GTGACAATGG GAGACTCCAT CTCAAAAAAA AAAAAAAAAA AAAAAAGATA AAAAGTCAGA AATCTGAAAA GTGGAGGAAG AGTACAAATA GACCTAAATT AAGTCTCATT FTGGCTTT GATTGGGG AGACAAAGGG AAATGCAGCC ATAGAGGGCC TGATGACATC CAATACATGA GTTCTGGTAA AGATAAAATT TGATACACGG TTTGGTGTCA TTATAAGAGA AATCATTATT AAATGAAGCA AGTTAACACT CTAAGAGAAT TATIliGAGA TAGAAGTGAA GCTAAGCTAA ACTTCACATG CCTATAATTG GAGGGAAAAA CTAAGGATAA AATCTAGCCT AGAAGATACA ATAATTAGTC ATAAACATGC ATTGTGAAAC TGTAGAGAGC AGGTAGCCCA AAATAGAGAA AGATTAGATA AAGAGAAAAT AAGTATCCAT CAGAGACAGT ATCTCTAGGC TrGGGCAAGA GAAAAGTCCA CAGTGATAAG CAACTCCACC TAAGGCATGA ATATGCGGCA GAGAAAACAG CAATAGTGAA TGAATGCAAA AGGTGCTGAG CAAATrCCAC ACATGAGTAT TGTGCATGAG TAAATGAATA AAACATTTGC AAAGACCTT AGAGAAAGAG AATGGGAGCA TATGTGCGAA ATAAGATAGT TGATTATGAA TAGAAGGTAG TGAAGAAAAG CAAGCTAAGA AAAAATTCTG TATAAAAG AAGGAAAAGA TAGTATGT TAGCCTA AGTATAAGAG TCCTACAGAT GGACTGAAAA AAATCAGTCT GAGAGTATTA GTCACAATTA ATGAAATAAT TACATTAT GTATrGAGGA TGCCAAGATT AAAAGGTGAC AGGTAGATGT TAATMTCCCT AGATTGTGAA AGTGATCACG ACAATCACAC AACAAATAAT TAAGTGACTT GGTATGCTTT ATTTAATTGT AGGGCCTGAG GTTCCATT CTCATTC TAAAATACAA TTTTGTTTCT CCAAATTGA CAGCAGAATA AAAACCCTAC CCTTTCACTG TGTATCATGC TAAGCTGCAT CTCTACTCTT GATCATCTGT AGGTATTAAT CACATCACTT CCATGGCATG GATGTTCACA TACAGACTCT TAACCCTGGT TTACCAGGAC CTCTAGGAGT GGATCCAATC TATATCTTA CAGTTGTATA GTATATGATA TCTCITAT TTCACTCAAT TTATATTfC ATCATTGACT ACATATTCT TATACACAAC ACACAATTA TGAAIT 1 CTCAAGATCA TrCTGAGAGT TGCCCCACCC TACCTGCCTT TTATAGTACG CCCACCTCAG GCAGACACAG AGCACAATGC TGGGGTTCTC TTCACACTAT CACTGCCCCA AATTGTCT CTAAATTTCA ACTCAATGT CATCTCTCC ATGAAGACCA CTGAATGAAC ACCTITCAT CCAGCCTTAA TTTCTTGCTC CATAACTACT CTATCCCACG ATGCAGTATT GTATCATTAA TTATTAGTGT GCTTGTGACC TCCTTATGTA TTCTCAATTA CCTGTATTG TGCAATAAAT TGGAATAATG TAACTrGATT TCTTATCTGT GTTTGTGTFG GCATGCAAGA TTTAGGTACT TATCAAGATA ATGGGGAATT AAGGCATCAA TAAAATGATG CCAAAGACCA AGAGCAGTT CTGAAGTCCT CCTTTTCATC AGCTCTTTAT CAAACAGAAC ACTCTATAAA CAACCCATAG CCAGAAAACA GGATGTAGGA ACAATCACCA GCACACTCTA TAAACAACCC ATAGCCAGAA WO 00/09525 PCT/US99/17712 EPI-109 37 AACAGAATGT AAGGACAATC ACCAGCCATC TTGTCAAT AATTGATGGA ATAGAGTTGA AAGGAACTGG AGCATGAGTC ATATTTGACC AGTCAGTCCT CACTCTTATT TACTTGCTAT GTAAACTTGA GAAAGCTTTT TTCTCTGT GAACCTCAGG TTTACATCT GAAAATGAGA AAITTGGAAC AAAAGATTCC TAACTGGTCT TTCTGTrCCC ATATTCTGTG ATITTCAAT ATTTAGGATT TTTGGTAATC ACAATTACTT AGTTrGTGGT TGAGATAGCA ACACGAATCA GAACTATTTG GTGGACATAT TTTCAAAGGA GTAGCTCTCC ACTGGGTA AAGAAGTGAT GCNGGTCGTG GTGGCTCACG CCTGTAATCC CAGCACTTTA GGGAGGCCAA GGCGGGTGGA TCACGAGGTC AGGAGATCGA GACCATCCTG GCTAACACGG TGAAACCCCG TCTCTACTAA AAAATACAAA AAATTAGCCA GGCGTGGTGG CGGGCGCCTG TAGTCCCACG TACTCGGGAG GCTGAGGCAG GAGAATGGCA TGAACCAGGG AGGCGGAGCT TGCCGTGAGC CGAGATAGCG CCACTGCAGT CCCTCCTGGG CAAAAGAGCA AGACTGCGTC TCAAAAAAAA AAAAAAAAAA AAAAAAAGAA GTGTGTGGAG TAGCAGGACA CCTGCAACAA TAATATTT CTAAATCCCT CTGAAAAATG CTAATCAAAG GGTTTTC CTAAAAATTG TCTTAGAAAT AAAATTTCCC CTTTGGGAGA CCGAGGCTGG CAGATCACGA GGTCAGGAGA TAGAGACCAC GGTGAAACCC CGTCTCTACT AAAAATACTA AAAATTAGCC GGGGNGTGGT GGTGGGTACA CCTGTAGTCC CAGCTACTTG GAGGCTGAGG CTGGAGAATC ACGTGAAC GCCACGTGCT GCTGGGTCTC AGTCCTCCAC TTCCCGTGTC CTCTGGAAGT TGTCAGGAGC AATGTTGCGC TTGTACGTGT TGGTAATGGG AGTTTCTGCC 'TCACCCTrC AGCCTGCGGC ACACACAGGG GCTGCCAGAA GCTGCCGGTT TCGTGGGAGG CATTACAAGC GGGAGTTCAG GCTGGAAGGG GAGCCTGTAG CCCTGAGGTG CCCCCAGGTG CCCTACTGGT TGTGGGCCTC TGTCAGCCCC CGCATCAACC TGACATGGCA TAAAAATGAC TCTGCTAGGA CGGTCCCAGG AGAAGAAGAG ACACGGATGT GGGCCCAGGA CGGTGCTCTG TGGCTTCTGC CAGCCTTGCA GGAGGACTCT GGCACCTACG TCTGCACTAC TAGAAATGCT TCTTACTGTG ACAAAATGTC CATTGAGCTC AGAGlTilTG AGAATACAGA TGCTCCTG CCGTTCATCT CATACCCGCA AATTAACC FTGTCAACCT CTGGGGTATT AGTATGCCCT GACCTGAGTG AATTCACCCG TGACAAAACT GACGTGAAGA TTCAATGGTA CAAGGATTCT CTTCTTGG ATAAAGACAA TGAGAAATT CTAAGTGTGA GGGGGACCAC TCACTTACTC GTACACGATG TGGCCCTGGA AGATGCTGGC TATTACCGCT GTGTCCTGAC ATTTGCCCAT GAAGGCCAGC AATACAACAT CACTAGGAGT ATTGAGCTAC GCATCAAGAA AAAAAAAGAA GAGACCATTC CTGTGATCAT TTCCCCCCTC AAGACCATAT CAGCTTCTCT GGGGTCAAGA CTGACAATCC CGTGTAAGGT GTTTCTGGGA ACCGGCACAC CCTTAACCAC CATGCTGTGG TGGACGGCCA ATGACACCCA CATAGAGAGC GCCTACCCGG GAGGCCGCGT GACCGAGGGG CCACGCCAGG AATATTCAGA AAATAATGAG AACTACATTG AAGTGCCATF GAITI-11GAT CCTGTCACAA GAGAGGATTT GCACATGGAT TTTAAATGTG TTGTCCATAA TACCCTGAGT TTTCAGACAC TACGCACCAC AGTCAAGGAA GCCTCCTCCA CGTTCTCCTG GGGCATTGTG CTGGCCCCAC TCACTGGC CTTCTTGGTT TGGGGGGAA TATGGATGCA CAGACGGTGC AAACACAGAA CTGGAAAAGC AGATGGTCTG ACTGTGCTAT GGCCTCATCA TCAAGACT CAATCCTATC CCAAGTGAAA TAAATGGAAT GAAATAATTC AAACACAAAA AAAAAAAAAA AAAAAAAA GCCGGAGCCG ACTCGGAGCG CGCGGCGCGG CCGGGAGGAG CCGAGCGCGC CGGGCGCGGC GTGGGGGCGC CGGCTGCCCC GCGCGCCCAG GGAGCGGCAG GAATGTGACA ATCGCGCGCC CGCACCGTAG CACTCCTCGC TCGGCTCCTA GGGCTCTCGC CCTCTGAGCT GAGCCGGGTT CCGCCCGGGC TGGGATCCCA TCACCCTCCA CGGCCGTCCG TCCAGGTAGA CGCACCCTCT GAAGATGGTG ACTCCCTCCT GAGAAGCTGG ACCCCTTGGT AAAAGACAAG GCCTTCTCCA AGAAGAATAT GAAAGTGTTA CTCAGACTTA TTTGTTTCAT AGCTCTACTG ATTTCTTCTC TGGAGGCTGA TAAATGCAAG GAACGTGAAG AAAAAATAAT TTAGTGTCA TCTGCAAATG AAATTGATGT TCGTCCCTGT CCTCTTAACC CAAATGAACA CAAAGGCACT ATAACTTGGT ATAAAGATGA CAGCAAGACA CCTGTATCTA CAGAACAAGC CTCCAGGATT CATCAACACA AAGAGAAACT TTGGTTTGTT CCTGCTAAGG TGGAGGATTC AGGACATTAC TATTGCGTGG TAAGAAATTC ATCTTACTGC CTCAGAATTA AAATAAGTGC AAAATTGTG GAGAATGAGC CTAACTTATG TTATAATGCA CAAGCCATAT TTAAGCAGAA ACTACCCGTT GCAGGAGACG GAGGACTTGT GTGCCCTTAT ATGGAGTT TTAAAAATGA AAATAATGAG TTACCTAAAT TACAGTGGTA TAAGGATTGC AAACCTCTAC TTCTTGACAA TATACACTTT AGTGGAGTCA AAGATAGGCT CATCGTGATG AATGTGGCTG AAAAGCATAG AGGGAACTAT ACTTGTCATG CATCCTACAC ATACTGGGC AAGCAATATC CTATTACCCG GGTAATAGAA TTTATTACTC TAGAGGAAAA CAAACCCACA AGGCCTGTGA TTGTGAGCCC AGCTAATGAG ACAATGGAAG TAGACTTGGG ATCCCAGATA CAATTGATCT GTAATGTCAC CGGCCAGTTG AGTGACATTG CTTACTGGAA GTGGAATGGG TCAGTAATTG ATGAAGATGA CCCAGTGCTA GGGGAAGACT ATTACAGTGT GGAAAATCCT GCAAACAAAA GAAGGAGTAC CCTCATCACA GTGCTTAATA TATCGGAAAT TGAAAGTAGA TITTATAAAC ATCCATTTAC CTGT=TTGCC AAGAATACAC ATGGTATAGA TGCAGCATAT ATCCAGTTAA TATATCCAGT CACTAATTTC CAGAAGCACA TGATTGGTAT ATGTGTCACG TTGACAGTCA TAATTGTGTG TTCTG'TTC ATCTATAAAA TCTTCAAGAT TGACATTGTG C1TTGGTACA GGGATTCCTG CTATGATT CTCCCAATAA AAGCTTCAGA TGGAAAGACC TATGACGCAT ATATACTGTA TCCAAAGACT GTTGGGGAAG GGTCTACCTC TGACTGTGAT A1I11GTGT TTAAAGTCTT GCCTGAGGTC TTGGAAAAAC AGTGTGGATA TAAGCTGTTC ATTTATGGAA GGGATGACTA CGTTGGGGAA GACATTGTrG AGGTCATTAA TGAAAACGTA AAGAAAAGCA GAAGACTGAT TATCATTTA GTCAGAGAAA CATCAGGCTT CAGCTGGCTG GGTGGTTCAT CTGAAGAGCA AATAGCCATG TATAATGCTC TTGTTCAGGA TGGAATTAAA GTTGTCCTGC TTGAGCTGGA GAAAATCCAA GACTATGAGA AAATGCCAGA ATCGATTAAA TTCATTAAGC AGAAACATGG GGCTATCCGC TGGTCAGGGG ACTTTACACA GGGACCACAG TCTGCAAAGA CAAGGTTCTG GAAGAATGTC AGGTACCACA TGCCAGTCCA GCGACGGTCA CCTTCATCTA AACACCAGTT ACTGTCACCA GCCACTAAGG AGAAACTGCA AAGAGAGGCT CACGTGCCTC TCGGGTAGCA TGGAGAAGTT GCCAAGAGTT CTTTAGGTGC CTCCTGTCTT ATGGCGTTGC AGGCCAGGTT ATGCCTCATG CTGACTrGCA GAGTTCATGG AATGTAACTA TATCATCCTT TATCCCTGAG GTCACCAGGA ATCAGG-3'(SEQ.ID NO:2409) Human Enzyme-related Antisense Polvnucleotide 5'-CTT GCT CCT GGG GGC CTC CTG GTC CCT CTG GCT G TT CCC GGC CCT GGB CTG GGG CBG GGG CCG CGT BGG CGC WO 00/09525 PCT/US99/17712 EPI-109 38 GGC TCG CCB GGB CGG GCB GCG CCB GCB GCB GCB GGC TCB GCB TCC TGG CCB CGG BBT TCC GGT GTG CGG GGC CTG GTG CC CCr GGG CCT CGG GTG CTG CCT GT GCG CTG CCr TCT TCT CCT GG GTC CTC GCC GGG GCC CTT GCT GCC CTG GCT GT GCC CTG GGG GTC TGG Gn CGG CTG T CCC CBG CBG GBC CBG TCC CBT CCB CBG CGT GTG BTG BGT BGC CBT TCT CCT GCB GCC GBG GGG CGC GGG CGB GCB TCG C TT GGG CT TTC TCC TTT GGT T TGB GCG CCB GGB CCG CGC BCB GCB GCB GGG CGC GGG CGB GCB TCG CBG CGG CGG GCB GGG GGGCTCCCGC CGCGBGBGGT TBTGGGCTCC CBGGBCCBCC CGCBCCGCGC GGBCGTTTBC BTTCGCCBCG CBGTGCGCGG CCGBCBTGBC GBBGTTGGGC GCBBTCBGGG TGGCGCCGCB GBBGTGGCCT CCGCGCBGCT GCBGGGBCBC CBTGBBGGGC CBCGCGTGGG GCCGCGCTCG CCGGCCCCCC BCBBTCTCCG BGGCCBGCGC GGTGCCCCCC BGCBGCBBGG CCGGCBGGBC BCBGGCGBGG BGBCBCGCGB GTCGGCGGCC GBGGGTCBTG GTGGGGCTGG GGCTCCGGGG TCTCTGCCCC TCCGTGCTGG TGGGGCTGGG GCTCCGGGG TCTCTGCCCC TCCGTGCCGC GTGGGGCCGC GCTCGCCGGC CCCCCCCTGC CGGGTGGGCT CCCGCCGCGC GCCGGCCTGC CGGCCCCTCG TGGGTCCTGC TGGCCGGGTC CGGGTCCCGG GGGTGGGGCG CGBGTCGGCG GCCGBGGGTC CCCTCCBCBT CTGCTCTGBC CTGCTGGBCT CTGGBTCTGB BGBTBCGCCB TGTBGGGGCG GGBGTGGGGC CTGCTCTCCC GGCCTCCGBT GBTCTCCCCT GCCTCBGCCC CBGTGGGTBG GBGBBBGGCC BGCBGBBGCB GGBGTGGCTG CBTCTTCCT GGTGGGGCCT GCTCTCCCGG CCTCCGTGTG TTGCTGGGTG TTCCCGTC TCTGGTCTGC CTTCGGGGGT CGT CCGGGGCTGC BGCBBCCTCB TCBGCTCTTG CCTGGBGTGG CTCBGCCTGG GCCTGCBGGG CCBCCBGGBG BBTGGCBGCB BGGBTGGCGB GGGTCCTCBT GGCTGGGGTC BCBGBTCCTC TBGCTBGGCB GGGTGBCCBG BGBGGGC GGG TCC TCB TGG CTG GGG GCC TGG GCC TGC BGG GCC GCT CT GCC TGG BGT GGC TC GCC CBG BGT CT CCC TGG T CGCTGCBBTC TGCTCCGGGG CTGCBGCBBC CTCBTCBGCTC TTGCCTGGBGTG GCTCBGCCTGG GCCTGCBGGG CCBCCBGGBGB BTGGCBGCBBG GBTGGCGBGGG TCCTCBTGGC TGGGGTCBCCT GGBGGBGGGB GBGCBGGGGG TCCTCBTGGC TGGGGTCCCT CTCTCCCGTC CT CGG TIT CCT TTG CGG TC nTG GCC CGG GCT CCG GGT G CCC GCC CGC CCG CCG GCC GCC GC CCC GCC GGG CTG TCC CCG CCC CGC CCC GGC CCG GGG CGC GGG GG CGG CCC TCC CGC CCC TC GG GCC GGC GCG GGC GTC GG CCG CTC GCG CCT GGG GTT CCC TCT CCT CCC CCT GTG C GCC TGC CTC TG CTC TTCTGC GTC CGC TGC CTT CTC CC arC TCC TCG GCC GTT GCC TGT GC TGT CCG TCC TGT CGC CCT TCC GTG GTG C TGT TGT CTC TC TGC CCT C GGT GTG CTG GTG CTG GTG GTG GTG CCT CTG CCC GTG CTC GCCCTG CCT GGG CTG GCC TCT TCG GGT GTG GCT TTG GGG CTC TCT TGG TTG CCC TTT C CTC GTG GTG CCT CTC CTC CCT GGC TTG GTC GT TGT CTG GGG TGG TGC TCC TCT CCC TTT CCC TGC TGG CCO T7 OCCT GTT TTC TGT CT CCT CT TC CTC CTG TT CTC CGT TTG GCT TGC TGC TTG CGG GGC TGT CTC C CTT GCC CCT GTG GGC TT CCC TGG TCC GGT CT CTC CTT GGG GGT C GCC CT CTT GGT GGG CTGGCT CGT CTG TCT TTT TCC TTC C TGG GGG TGG CCG TTG TGG GCG GTG TGG TCC GCC T TGC CTC TGC TGG TCT TTC CTCGGTBGBC GCGCTCGBBC TCGGGTGGGC CGGTGGTGBG CGGCGGCGBCB CGCGGBBGGC CCTGCGCGCC GBGBTCBCCTG CBGGGBGBBG TBGGCTTGCB GCBGGBCTCC CBGGBGGGTG BCBGCBGCCB GTBGBGCTBC CTCGTCCTTC BTGGTBCCGT CGGTGTGGTG GCBCGGGCTG TGTGTGBBGG CGBGCTGGGC CCCGTCTGCT GCTCCTCGTG CCGCCTCGTC CTTCA TGG TA CCGTCGGTGT GGTGGCCTCG GGTGGGCCGG TGGTGGGGCG CGCGCGCTCG CGTGGCTCCG GCTCTTCTT CCCGGCTCCGT CGGCCCGGGG GCCTTGGTCT CCCTCGTCCT TCBTGGTBCC G BCCGGCGGBG CCGCCBGGGT GGBCTGGGBG TGGGTCTC CCCGCCGTC TCBCCCBCCG CGCTGBGCTC BGCGCCTBBG BCTGCTGrT CTGGBGCTCC TTGGCBBGCC BCBBBCBGCB GBGBGBBBBT CBTGBGCBBB TBBTCCBTTC TGBBBBBBBG GGBTCBBBBB CCTCCCGTTC CCCGTCGCC TGGCGCGCGC TGCGGGTTCC TCGTGGGTTT CTCCCCGCCG nCTCCGGTC TGTnGCCTIT GTGGGCTTCT TGTCTlIi iG GCTGT7T- TCCTGCTTGG CGTC'ITITCC T'TTCTTGTG CTCGGTGTG GGTCCGCTGG TCCITTGCCC TGTGTGTTTC TGCTGCCCGT TCGCCTGGCG CGCGCTGCGG GTTCCTCGTG GGTTCTCCC CGCCGTrCTC CGGTCTGTrG CCITTGTGGG CTTCnGTCT =ITTGGCTGT TICGCCTG CTTGGCGTCT 'TTCCTCT TTGTGCTCGG TTGTGGGTCC GCTGGTCCT TGCCCTGTGT GTCTGCTG GGBGCTGBTB CTGCBGAT CBGBGGGBBG BBCCCTGBTB CrCBCCBGCT TCBGCTCTGG BGCBCBBGBG BBBGBGCBGC BGGGGGBGBG GBBGBBGCBG CBTCTCCCB GBGBGGCTGC CTGBGCBBBT GCTGGliTC CTTCCBGTC TTGGGTB TBBCTCCCBG BBGGCBBGBG BGGGGCBBGG CGi CTTC TCTCGCTGGT TTTCCTTCC TGGCAGTGGG TGGGGGTGGG GGTGGGGTGG CCCnG CCTGGGGGTG TCCTCTTGCT CTGGGCTTT CTCCCClT CCTTCCTGTC TG ITlCCTG GGGCTCTCCT CTGTCTCTGT GTCCTGCCC TGGCCCTCTT CCCTCTCCTG TCTCCTGTCC CTGTGTTCCG CCCGTCTTCC CTCTCCTGAC CTCClrrrCC TCCGCTGGGT GGGGCCCTGC CTGrCTCTG CTCCCTGGCT TGGGGTrCT TCTGTGTGTC TTCTTCCTCT GTrGGCTGGC T'TCTrCCTC TTTGTCTTC CTGGGTGCCC CTTCTTCCTn TCTTGGGTCC TTGGTGCTG GGCTGGG GCGTCTTGGG GTGCBGGGCC CBTCCTGCTG CGCCTGGGCG CTGCTGTGCG TCCGTCTGCT GGGGGGCCGG GGTGGCTGGG CCCTGCTGC CGCACGACCC CGGGCCGACC CGAGGCTCGG GGGGCTGTGT TCGOCOCTO OTOOOCTTO occcararoo oooarooon TCCTGCTGCG CCTGGGCGCT GGCGTCTTGG GGTGCGGGGC CGGGGGGCCG GGGGGCCGCT GTTCGTGGGC CTGGGGGTGC CTGTGGCTGC CGGTTGCCCC GGTTGGTGGC GCCGTCCTGC TGCCGGTCGT TGGCTGGGTC CCCCCGCCCG TTCCTGGGG TCCGCGTGGG GTGCTCCGGT TCCTCGTGCC GCTGCTGCCT TGTCTTCCG GCCGTGGCGG CGTGGTGGTC CGCCCCCCCT GGCCCTGC TCGGGGTCTG GCTGGTrGCC GGTGCCCTG GCGGCGGTa TCTTCCTGGT GGCTCTGGGC CCGGCCGGTC TCGGGCGTCT CGTGTTCGCT CTTGTGCTGT TCGGGCCGCT CCTnCCTCTr CCGCCGCCGC CGCTCCCCGC CCGCTCGTCG CCCTGGCCCG GCarCCrCCT GGCCGCTGTC TCGGGCGGCG GCCTrGGCGC TCCGTTGGG GCTGCCTCTG GCGCTCCGG CCCTCGGCCT GGGCGCTCTC TCCGCCrGT GCTGGTGGCC CTCGTGGGCC CCTCCTGGCC TCCGGTGTCC TGTGGTCCCC CGGCTGGTGG CCGGGCCGGT TGGGCGGGCG TGGGCGCCGG CGGGTCCTCC GGGCTGCCCT TCTCCGCCGG GGGTCCCGCG CrCCTGCTGT TCCCTGGGCT CCTGCCTC TCTCCTGGGT GGGTGCTGGG TGCCGGGGTC TCCGGGCTG CCCCGCGCTG CTGGGCGTTC TGCGGTCTTG GGGTGTCTG TGGCCCCGCT CGTGTCGCCC TCCGTCGCCC GTCGCCGGCC TCGTCCCCTC CTGGGTGCGC GGCGGGCTGG TCCTGGCGTT TTGCTCCnC CrGGGCGTCT TGGGGTGCBG GGCCCBTCCT GCTGCGCCTG GGCGCTGCTG TGCGTCCGTC TGCTGGGGGG CCGGGGTGGC TGGGCCCrGC TnGCCGCACG ACCCCGGGCC GACCCGAGGC TCGGGGGGCT GTGrrCTGGC GCTGGTGGGC TTGGGCCCCT CTGGGGGCTG GGTTCCTGC TGCGCCTGGG CGCTGGCGTC TTGGGGTGCG GGGCCGGGGG GCCGGGGGGC CGCTGTrCGT GGGCCTGGGG GTGCCTGTGG CTGCCGGTTG CCCCGGTGG TGGCGCCGTC CTGCTGCCGG TCGTGGCTG GGTCCCCCCG CCCGTTTCCT GGGGTCCGCG TGGGGTGCTC CGGTTCCTCG TGCCGCTGCT GCCTTGTC TCCGGCCGTG GCGGCGTGGT GGTCCGCCCC CCCTGGCCTT CTGCTCGGGG TCTGGCTGGT TGCCGGTGCC CTTGGCGGCG GTCTTCTTCC TGGTGGCTCT GGGCCCGGCC GGTCTCGGGC GTCTCGTGTT CGCTCTTGTG CTGTrCCGGC CGCTCCTTCC TCTTCCGCCG CCGCCGCTCC CCGCCCGCTC GTCGCCCTGG CCCGGCCTCC TCCTGGCCGC TGTCTCGGGC GGCGGCCTTG GCGCTCCGTT TGGGGCTGCC TCTGGCGCTT CCGGCCCTCG GCCTGGGCGC TCTC=fCCGC CTGTGCTGGT GGCCCTCGTG GGCCCCrCCT GGCCTCCGGT GTCCTGTGGT CCCCCGGCTG GTGGCCGGGC CGGTTGGGCG GGCGTGGGCG CCGGCGGGTC CTCCGGGCTG WO 00/09525 PCTIUS99/17712 EPI-109 39 CCCTI'CTCCG CCGGGGGTCC CGCGCTCCTG CTGTTCCCTG GGCTCTrCTG CCTCTCTrCCT GGGTGGGTGC TGdGTGCCGG GGTCTrCCGGG CTTGCCCCGC GCTGCTGGGC GT7CTGCGGT CI1TGGGGTrG TCTGTGGCCC CGCTCGTGTC GCCCTCCGTC GCCCGTCGCC GGCCTCGTCC CCTCCTGGGT GCGCGGCGGG CTGGTCCTGG CG'TITGCTC CTTCCTGG CTGCCCCBGT TITGBTCCT CBCBTGCCGT GGGGBGGBCB BTGGCTGCCT CCCCGGGGTr TCTGCTGCT[ GCTGCT7CTF TCCCGTCTCC crcrCCC GTCTCCTTP TGCCTCMTG GGT7CCTGTr G=ICTGGCC TGCTTGGTGG CGGCT~rGTGC GTCCTCTrC TCTTrCTTG GGTCTCCGCT TC TCGTCCTG CCTITCCTG TCTCTGTCGC GCCGTrCCTC CTCCGGCGTC CTrCCTGCCCT GTGCTGTTG CCTCGGGTGG TGCGGGTCCC GGTGCTCCCC CGGCGGGCCG GCTGGT7GCC TGGGCCTGTC TGGTGGGGTG TGGGGCCGCT GGGTTGGGGG TGTGGTGGGC TCTFCTGTGG CCTGTGGGGC TG3TrGGTGTC TCTrGTGGGCG TGTGCTGGGT CT'rGGGGC'rr CCTCC=TGT GCTGGGTGCG GCCTCCCCGC CCCCCTrCTG GGCCGGTGGC CTFGGCTCCTT GTGGGCGCTr CTGGCTCT7G CCCTGTCCM CTrCGCCTCG TGGCTFGCTGG GCTGC GCCGCCGCCG CCAAGATGGC GGACCTGGAG GCGGTGCTGG CCGACGTGAG CTACCTGATG GCCATGGAGA AGAGCAAGGC CACGCCGGCC GCGCGCGCCA GCAAGAAGAT ACTGCTGCCC GAGCCCAGCA TCCGCAGTGT CATGCAGAAG TACCTGGAGG ACCGGGGCGA GGTGACCMI GAGAAGATCTr T7CCCAGAA GCTGGGGTAC CTGCrTrCC GAGAC'rrCTG CCTGAACCAC CTGGAGGAGG CCAGGCCCT7 GGTGGAATTC TATGAGGAGA TCAAGAAGTA CGAGAAGCTG GAGACGGAGG AGGAGCGTGT GGCCCGCAGC CGGGAGATCT TCGACTCATA CATCATGAAG GAGCTGCTGG CCTGC TCGCA TCCC TTCTCG AAGAGTGCCA CTGAGCATGT CCAAGGCCAC CTGGGGAAGA AGCAGGTGCC TCCGGATCTC TTCCAGCCAT ACATCGAAGA GA'IMGTCAA AACCTCCGAG GGGACGTGTT CCAGAAATTC ATTGAGAGCG ATAAGTTCAC ACGG=fTGC CAGTc3GAAGA ATGTGGAGCT CAACATCCAC CTGACCATGA ATGACTTCAG CGTGCATCGC ATCAtI'GGGC GCGGGGGCTT TGGCGAGGTC TATGGGTGCC GGAAGGCTGA CACAGGCAAG ATGTACGCCA TGAAGTGCCT GGACAAAAAG CGCATCAAGA TGAAGCAGGG GGAGACCCTG GCCCTGAACG AGCGCATCAT GCTCTCGCTC GTCAGCACTG GGGACTGCCC ATrCAITGTC TGCATGTCAT ACGCGT7CCA CACGCCAGAC AAGCTCAGCT TCATCCTGGA CCTCATGAAC GGTGGGGACC TGCACTACCA CCTCTCCCAG CACGGGGTCT TCTCAGAGGC TGACATGCGC TrCTATGCGG CCGAGATCAT CCTGGGCCTG GAGCACATGC ACAACCGCYr CGTGGTCTAC CGGGACCTGA AGCCAGCCAA CATCCTTCTG GACGAGCATG GCCACGTGCG GATCTCGGAC CTGGGCCTGG CCTGTGA=T CTCCAAGAAG AAGCCCCATG CCAGCGTGGG CACCCACGGG TACATGGCTC CGGAGGTCCT GCAGAAGGGC GTGGCCTACG ACAGCAGTGC CGACTGGTTC TCTCTGGGGT GCATGCTC= CAAGTTGCTG CGGGGGCACA GCCCCTCCG GCAGCACAAG ACCAAAGACA AGCATGAGAT CGACCGCATG ACGCTGACGA TGGCCGTGGA GCTGCCCGAC TCCTTCTCCC CTGAACTACG CTCCCTGCTG GAGGGGTTGC TGCAGAGGGA TGTCAACCGG AGATTGGGCTr GCCTGGGCCG AGGGGCTCAG GAGGTGAAAG AGAGCCCCTr TTCCGCTCC CTGGACTGGC AGATGGTCT CTTGCAGAAG TACCCTCCCC CGCTGATCCC CCCACGAGGG GAGGTGAACG CGGCCGACGC =TCGACATT GGCTC=TCG ATGAGGAGGA CACAAAAGGA ATCAAGTTAC TGGACAGTGA TCAGGAGCTC TACCGCAACT TCCCCCTCAC CATCTCGGAG CGGTGGCAGC AGGAGGTGGC AGAGACTGTC T-rCGACACCA TCAACGCTGA GACAGACCGG CTGGAGGCTC GCAAGAAAGC CAAGAACAAG CAGCTGGGCC ATGAGGAAGA CTACGCCCTG GGCAAGGACT GCATCATGCA TGGCTACATG TCCAAGATGG GCAACCCCT CCTGACCCAG TGGCAGCGGC GGTACTrCTA CCTGrrCCCC AACCGCCTCG AGTGGCGGGG CGAGGGCGAG GCCCCGCAGA GCCTGCTGAC CATGGAGGAG ATCCAGTCGG TGGAGGAGAC GCAGATCAAG GAGCGCAAGT GCCTGCTCCT CAAGATCCGC GGTGGGAAAC AG'rrCATI= GCAGTGCGAT AGCGACCCTG AGCTGGTGCA GTGGAAGAAG GAGCTGCGCG ACGCCTACCG CGAGGCCCAG CAGCTGGTGC AGCGGGTGCC CAAGATGAAG AACAAGCCGC GCTCGCCCGT GGTGGAGCTG AGCAAGGTGC CGCTrGGTCCA GCGCGGCAGT GCCAACGGCC TCTGACCCGC CCACCCGCCT CCAGGAAGCT ACCTGGAGGA GGTGAcITCT AGCGGATGAG TAGGAGTTGT CCACGGAGGA AGGTACACAG AAGGGC=CC AGGCCCAGGA AACAGCAGAG GCACAGAAGT GAGAATGGGT GGGTGAGT7G GTGGGGAAAC TCCAGGTGCA GAGGATGGTA GCGAAACAAA CTGGAGCATr AAGGTCCAAG TCCTCCAAGA T=1TGAC17G CAGAYTAAGG AGT=GTrTCA CCTAATCTGC 1GGGCAGA GTGTGGTGAG TCCTAGAGAC CCCTC TAGGT CTCTCCTCTC AGTAGCCCCA GAAGGCCTGG AGAGCTGC77 CTGGGTGCCA AGCAGGCAGT GACTCCATCA GATCTAGATT TGGGAAAAGC ATCCCTGGTC AGGGCCTGCA TCAGGGCAGT GGCTGGCCAT GAGGACCCTG AGAAGTAGAC AGArrCACGG AGATrCTCAG GAGGCCAGAC AGGAGACTAT GGTGACAAAT TAGATTAGAG AAGGGGAGAG AATGAAGGAG CAGTTGGGGT AAAAGAAAAC TGAGGCTGAC ATGGGTATAT GGGTGGCGAG TGACTCACCA CCCACTGAGA GGAGAACCTC ACAAGCTCTG ACATGCTCTG GTrCCAGGT7 CTGTI'GGGGC TGATCCAAGA TGGTAGCCTA GAGGTGCACA GAGATGGGGG C=TGCTTG CAAAAGGATG CTGGCTGCTG GCCCACAGCA TGGTAATGAG AM~GAGCTr TATGTGCCCA GGGCTGGGAG GAGGGTCCTG TCACTTGAA AGCAAAGAGA GGCTCTAGAG AGGGGCATGT TGAGATAGGA ATGCTGC=T GAGACACCTG GC'=CCCCA CTCTGGGTGG CTCTCAGCAG GGTGGG T7C CCCTGCCAGG CAGCACTGAA CCTCTGTGCG =ICCGGCTG GGAGAGTIT TACCGTAACT ACATGTGGAA CCATCCTGAA GGAACATCTG GATGGGATGG GGTACAGGGA AGGGAGCTGC CAAGAGTGCT GGCCAGGGAC CTGGGTCTAT GAGCTGGTTG GGGGGTGGGG T'TGGGTGCAG GGTAC17GAT CC TGAGTGGG C=TCTGCGG CCAGGAYFGG TTCTAGAGTA GGAGGGGTGG GATCGGGGAT GGGGGAAGCC TGTAACTGCG CTGCAGTrGT CAGGTCCCAG GTTCTGGGTG ACCTACTAAG GATFCTGGGT CCAGTGTGGG TCCCAGGTTA GACGTCCTAG TCCTGAGTCC GTGTCCACAG TTCTGGGTGT TGAGTCTAGG ACAGTGATCT GGAGTrGACA GTCCAATCTA GGTC TGAGTC CTGACCCCAA GTCTAGAGYr CAGGGTCATG GTAGTAGCCT AGGGTCAGAA TCAAGGflGG GGTCAGTAAC CAGGATGGGA TCGAGGTCAT GGTCCAAAAT CTGGATCTGG GGACCTGTTG GGGGTCTGAG GTGAGTGTCG CAGTCTGGGT ATGGCGTrGG AGACCCAGGG CTGTGATCTG AGGTCATGGT TAGAGTCTCA GGTGGTGGGC CAAGGTTTGA GTCTGGGGTC CTG'TMGGAG TCTGGTGTCA GGTCGTGGAC TGCGTCCAAG GTCAGGGAGT CCGGGGTTAT AGCCAGGGTC TGAGATGAAA GTCCCAGATG GTG'TCAGAG GTCTGAATCT GTGTCTrGGT GAGCGTCCAG GFTCCCTGTG ATCACG=~G GTGTCAGGGC TGCGGCCCGA CTGGGGAGCC TGGGATCCAG AGATGTGACC CGAGG1TGTG GTCAGAGAAT GGGTCTCGGG TCGTCTrCGT GCCGGGTCCC TGTCGTGTTC CAGGCCCGGG TCTCCGTCCA GCATCGAGGG CCGAGGTCAC GGCCAGGGTC TGAGCCCGCG GTCGCAGGTC TGGTTCGGGG TCAGATTCCG CGCGGCCTCC AGGGGGCGCC GTCGCCGCCC GGCTCGGCCC CTCGCGGGCT CGCrGGCGTIT GTGCGCGGCA GGCGGGGCCG GAGGCGGCGG CGGCTrCCGGG GGCGCGGGCC GGGCGGCGGC GGCGGCGGCG CCCCGACTGC AGTCCCGGCG GGAGCGGAGC GCGAAGCGCG GGGCCGGGCC CGGAGCCGGC GCCATGGGGC GGCGCCGCCT GTGAGCGGCG GCGAGCGGAG CCGCGGGCGC CGAGCAGGGC CAGGCGGGAG CGTCGGCGCC CGAGGCCGAG CGAGCCGCGG CCGGGCCGGG CCGAGCGCCG AGCGAGCAGG AGCGGCGGCG GCGGCGGCGG CGGCGGGAGG AGGCAGCGCC GCCGCCAAGA TGGCGGACCT GGAGGCGGTG CTGGCCGACG TGAGCTACCT GATGGCCATG GAGAAGAGCA AGGCCACGCC GGCCGCGCGC GCCAGCAAGA AGATACTGCT GCCCGAGCCC AGGTGAGGAG AAGCT TCCCAGTrAA TACATAATCA ATATGCAArr TATTAATACA TCTCTCCATG TCCACTCCCC CTGTATCTrG CCAT7CTrGA CCTGCATITC CATCCTCCTT ACCTTCCCTA GAGGCCAACT CATI=CMI GAAAAACCTG GCATrrCCCA GAAAAAAAAG TGAAGGGCTG GGAGCTGTCC GTrGTCCTGA 'FTGCTCCCT CTGCCCTrGC TrCCAAATGT GGTFGGAAAG AAGCACTAFT GAAAAATCCC WO 00/09525 PCTIUS99/17712 EPI-109 40 TAAACGCACC CCTGCAGGGT TGGCTCTACC CTGTAGCCAT GGACACATGC TGTTGATACC ACCTGCCTCA TGAdTcrCAC ATAA ITrGCC C=ICACACT ATCTACCCCA TCAGC=IAC CAAAACCATA CCTGCATCCT GGGCAGCATC TGCCCrCAA GAGACTAAGG AATCTC=TG CAACCAAGAA TGACTAGACC AATGAGACAC CC1IAAGGC CCCAGCACAA TATAGAAATC CCACAATATG GTAATCCCAG TAAGGAGCTA TCAAGCCAT7 GCAGGACCAT CTAGAATACA ACTAGAGTAT AGTTCC AATCCAGGAA CTATACTCTA ACAGCTTGGC TCACAGGAAC CAGAAGTGAA GATGATGAGG ATCAGGGCTG AGCCTGTGAG CACCAGCTCC ACCACTGACA CCAACCACAG ATrFAAACAAG CATC=GTGG ACCCCTGGGA TGGAAAGAAT AGTrG'rrGCC TT1ATCAACCT CCCCCACAGC CCACACAGAA AAGATAAAAT CATCATGGCT ACAGTGTTAC AGAAGATGAT GACCCAAGGA GTAGGCCTGC CTGAGTGAAT GCTGAGAGTG ATAATGGGAG CAGTAGCATC TCAGAGACTA CAGCAGAAAC CATCCACATA AAGAGC7TG CCCAAACTJA TGATAAAGGG CACCCTCAGA GACTCTCCCT AC1TAATAT TAGCCCATTG CAGAAATGGT GAGTGGAAAG AGAAATCTIA GGAAGAACCC =TAAAAAAG CAAAATG=T TTTAGG'1rG TGCTGAAGAG CCTGGAAAAG AAATAAGGAC ACACACGCTG AGAAATCTC CTCCTGCCCC AACACTGGGA TAATCTCCAA GGATCTCTCC ATATCTCA7 CTCCTGGATA CACTGTCCAC TCAGAAATAT TGTGCAGAGT GCAGTAATTC AAAAGTGAGC TAYrGTGTTA GGAGTGAAGG CAAGAGTATC GTAAAATAAA TCAAA1TrGA AATGAATTCT CTAAATTGC TIATAGATG TTAATGTAA GCCAGCAGCT ATTAAACGAT AAACCT-rAAA 'FCGAGAAAA ACTTGGTCAT TCAGAAACTA TAGAAACAGG CAGGACTAT TGCGAGGGCA AAC.ACAGAGT GAGCTCCAGC CTGCTrCAGG AAAATCTGCC AGTGCCATGA AGGATGTACT CTGTCTGCTC CACTGCACTA CTGCTCAGTA TGAGCCCATG CCATCAGCTG TCCCTGACCC ACAGGAG17C 71TAGAAGAG ACTGGTCAAC AAAAGMTCT AGGGTG=F~ ATACCTGCCA ACTCGAGGGT TAAAACAAGT TGCATAGAAA TGCTCAATCA AGAAAGACAC AGTCATTACT CAGAGAATAA TAAACAGCCT GGCAGCACAT GAATGAATAG AAAAAAGATG TTACATGCAA AGCATGAAAT AACCAAAT7C CATAACAGAT GTIAATCTGT AATGTG TTA GGAGAAT 1TA GAGGAAGTAT AAGATTrATT c'IrrCATCAA AAAAATrATA GCCAATGAGG ATATATCTAT CAATrATCCA TCAAGTGGTG ATATGGCAGC ACAAGGTAAA ACACAAAGGA ATAAAACCAA CGTMATTAA GAACCAATCA TGTGGCAT"17 CACAYrGAGC ATCATAMhA ATrCTGAAAA AAATCCT7GT ACTGTATCAT T=TCATATT 7rATGGATGC AGTAACTAAG GCTGAGAACT TTAAAAT1T TCCTAAG7TC AGACACATAG CTAAGTGGCA GAACCAAGAT TCAAACTCAC CCCATCTAAC TGCAGAGCAA ACTGCATGCC TrAAATGTCA AAGTGAATAC TAGCACAGT7 AATACAATGT TTGGAAACTC AGAGAAGGAA TGATCCCTCT GCATrATAGT TACTAAGGAA TCATTGCCAT TArAAATG CCAGTGCTIC TACATCAGGC CCAAAT=~C TGTCCTACTA ACTGTGAATC AAGACTGAT TCAACCTCTA CTTGAGTATC TGCCGCAATG AGAAATCACT TACCTCCACT AACCACACAT TTATITATA ACAACAGATr GTTAGTAAGT CC1TCTTAT ACATACTCAA CAGCTGCTTC CCAAGATGCT GTAGGA'17AT GTCTAGAGTC AAACTAGCCA GAAGCAATGT CCAAAATACA CCATAACACT GTGCAGCAAA GGTCCTACTA CCACTTG'FI GGCCCAAACA 'TrCTAGGCAG CACTGGATAT CTGAATCATC AATrATIT7CC ACAAACACTG ACCCCTCTAC CAGTCACCCT CACTAGAAGA ATTAATrCCA CATGATAATA GCTCCCTCAT GTTACTCCCT TCTAAGTCAA ATTGTACACC CCT=ATCTFG ATrAACAGAG TCTAAGTCAC ATGACCTAAA TGCAAGAGAA CTGGGAATGG ACGT7GTGG A'FrCrAC=~ AGTAAGGCAA AGTTATCATTr GGGAATTCCT CTAATACAGG AAGGGTGT7C CAGAGACA'FF AAGGAGCCAT ATAAATGGAA AATGTCCACT ACAATCCATC ACTTGGTITGC CCCACATCAA CATTCATTCT T'T7GCCACAC FAAAGTrC CAAGAACAAA AAITATCCCA CTGAACATAA TC1TACTAT CTI=ATATA AAGGAAAAT-f AGACTGACT CAGCAGAACT GAAATAACCC AGCTCTAACA GTTAVFCT TrAAC17CAA GTACTGTGTC TCTAGGTGAT ACCTGCTCCA ACAATAGTr GGTCACA'IM TCAAT17GAT ATrCTCTAGT CTCCCAACTT GATAACTGTA CCCTAAACCA TAAAGTTCAC TACCAACATG CrATATATAA AATAACCAAA GGGGGAAGAA GAAAGAGAAA AAGGAAAT~r CTrAAAATAC ACAGGTATAC ATATGACAAA GCAAAGAAGG AAATGTGAGC AGATAGTGCA GTCCTCGTTr CTGAAATrGG TCCCCTGACT GGGGCTATAC CTATrCCATT TCCTCACCCT CAGCCAGGCA GGTGGAGCAA AAACTrAAGT =TGGTGGAT CTGAATCTTG ATGCTGTGGA GCTGTC=AC TAGCCCCAGA CTACCTGCCT CTCAA TrCT AA'TTATATCA GTGAAAGCAA ACAGCI=GA 'ITTrAAG CCTCTGATIT7 TrGGTCTAA CTGATGTAAG ACCACAAGGA CAAGAGTI7CT CCAGCTCCGG AF[CTCTrCT G'FrC7T'AA TGGTGAAATG CCCGAGAGAA GAGTTGCCAA ='~GGCAAA TAAAAAATAC AGGATTCCAG TTAAAT7CAA A'ITrAGATAA ACAACAA'TT 'IAGTATrA GTGTGTCCCA TTCAATAMr GGACATACTT AACTAAAAAA TGA'TFGTTG TFCATCTGAA ATACAAAMT AACTGGGCAT TCTGAATATT CTCTGGCAAC CCCCGAGAGA GTGAAGAAAG TGGTACAAGG ACACITAAGA AGACCAGAT7 TGAAAAGACA FTACGGATGT GMTAAATGT CTTAT7CTAG AGAGAGT71AG AGCTGTAGGT AGAACTIGGG AAAT-7AAGT7 AAAAGCAGAC ACAGAGACCT GGCCAATATA TACTAAGGAG TGGATCACTC TGGTCACAAG CCCAACCTGA GACCAAGGGC ATAGTGAGAT GATITGGGAA AGGCACIAT ACACTACTCA TCCCCGTCTT TGAACTAAAT GCCT1rATAAA TCTCCAAGAG AAATGACAGT CCACCATGTG GACTGCI=C TGTAAGTCCA GGGAAAATAA AAGCTATGTG =~GAAACCC A=ICTGATA 'FrATAAGGTG TGTGATCTI GTCATGTrAA TGGGTCTGAG TATCAATrCT ACAATrGTAA AGTGACAGTA ATGGTGTGTC CCCAGGTTGT TGTGGAAAGC TrGATrCTrA ATGCAACAGT AGGAAACCCC AGCCTCTCTG GAGCAAACAC CCTrCTACAT CITACTTCC CCTGCACATT GGCAGGACTC TATrCCTCTA TITrCrCTCTA GTGCTAGAGC AGAAAGGGAC CrrGA'I=GA TATCAGGAAA ATCTA=~CT GAACCATAAG CTATGATAGC TGAn7AAAA AATTGACrAT CATGACATGA TAATGATCAT AATGGTAATA CATA ITGATA GGGTTGCCGT GAAAGTAATA ATATATCTAA GAGT7GTGAC AATATATGAT ACGCCTAGAC TCTCAGAAAA TGCTAATTCC AATCCCAATT GCTCITGCA TAAAGTTCTG TCCTAGGGTC TGTTCT=C CCACATCTAC CCTC=TGGA TCTCT=TCT GTCTITCA TGTGGT7CAG AGGAGGAGAG AGATCCAGGT CAATGTI= CAAATTACAA GGAATTATCA TrFAAATGGG GAAGAAGCTC AAGTITGAC GTGTAGTGGA A F7GGAGTGG AGTGGAGTGG AATGGAAACT AACAGGAAGA CACTGCACAT GGTAAGATA AAGAT7G'TrT CCTGAAACCT TrAATT17GTG CTrACATACT CACACATACA TATGTGCATG CACTGGGACT CTGCAATATG CA Tr7CTGAC TATGGAACAT AGCCATAAAA GTC=rGCAC TGAACG~ITCA GTGGGCCTI CACAAGCTGC CCTAATFGGG AAAGAAAAAC ATGGTCCCTC CA'ITCCTGC CCCCAACTCC AGAAAAGTCA CCATAGTrGA GGGTACATCT GAGAAGCCAG CACTTGGGAG ITCAGGGCTC AAGTFCCTT CTAGAAAAAC ACTGGGTGAT TCTAGGGGAA C~rCCGATCA GAAACAGCCA A77CAGAGTG AGAGAAGAAA ACGTGACCAT GCAGTI'CCTG TGGTrACCAG CCTGCCCCT CTCTrGCC= CTGGGAGTrA TAAAACCCAA GACTGGAAAG GAAAACCAGC A'rGCTCAG GCAGCCTCTC TGGGAAGATG CTG=~CT7C CTCTCCCCCT GCTGCTC3T CTCTrGTGCT CCAGAGCTGA AGCrGGTGAG TATCAGGG Fr CTTCCCTCTG AAATCTGCAG TATCAGCTCC TGAAACAAAG ATGT11AGTC TGAAATAGCT GACTCCTAAA CAGGGTrCCA AGATCTCTCT TCAAGAGTCC CACAGAGGAA AITCCACnT GGGATGTGTG CCACCCCACC CCCACCCCCA CCCACTGCCA TTCTCTACAG CCTAGGACAC CCCCAGGAAC AAGGAA'1C ACCTCAAT7G TAGAAAAGCC CAGAGCAAGT GGAAGGAAAp. GGGGTATCCC CAGGAAAACA GACATGTCCT CTTAATCI7C TGAGCATCAG GGCTACCCAT TACI=GTGA CT=CTCACT CTGTGACCAT GCTCAAGAGC TATGGAGAAA TCTAAAACAG GAACCTGGAC AGTGGGTCCT ACACAGAGAC AGAGGAGAGT GGGCCAGGGC AAGGTGGGAG TGGGAGAAGT CTGAGATGAA AACATCAGAA TGGAGCAGAG GCAAGAATGA GA I=CACCT GGGAGGTTAT GGGTGGGGAA AGATACGAAA TACAGGAGAC WO 00/09525 PCT/US99/17712 EPI-109 41 AGGAGAGGGA AGATGGGCGG AACACAGGGT GAGAATGAGA TTCCAGGGAA GCCTAGCTCA GCTTTAACCC AATTTGTCCA TTCATTGGAG AGAGTATCTA TGGCCGTGTT CAAACCCTGG GGTGCTCTGT TCCAGGGGAG ATCATCGGGG GCACAGAATG CAAGCCACAT TCCCGCCCCT ACATGGCCTA CCTGGAAATT GTAACTrCCA ACGGTCCCTC AAAATTTTGT GGTGGTTCC TTATAAGACG GAACTTGTG CTGACGGCTG CTCATTGTGC AGGAAGGTGA GACAACAGGG TCTATTTATC TCCAAATGGG AGATGAACAA CCAGAGTAGC ATCCAGGAAT ACACCTGCAC TGGGGACTGA AGAGGGGGTC CTGGGTCTTG TCAACTITCA GGAGAGGGAA GACTTGGGC TGAAAGACTT TAGTCTGTGT TTGAATAGTT CCTTGAGCCT CAGTCACTGA GCTAAGCTCC CTTCGGAGGA AAAGGAGGTC CTGTCCGAAG GTCCCTCTTG TTGCAGTAGC ACCCCTCACC CCTACCCAAC TCAAGACACA CGGCTCACTT TrCAGGGCCC CACCCAGTCT CAGGGCCACT TCCTCTATGG CCFTTCAAG AACACTGGCT CTAGTTCTCA GGGTCCTGAA CCCATCATTT TATGGGAGCA GAGAACAGGT CTACATAAGA CCCCCACTTT CCCGTTAA CTGATATCTC CTGCTTCAGG GGCTGGCCCT CATGCAGGGT TCCCTGAATT AGGAAGTGTG AACCCTGTCC CCTGAGTCCT CCCTGGCCTG TTCAGTCCCC AGCAATTCCA GGGGTCGTAG AAATTGTGTC TGTTTCCTGA GAAAGCTCTT TCATGAGTTA AGCCTGAGCC CTCAAATGCC ACAAGTGGCC CATGAAAAGG GAGATGGGTA GAGTCCGGCN ACCCAGTGAC AGAGTTAGT CCTCmTCT CAGAATGAGC TCACCTCAGA AGAAACCCCA AGCCATCACT GTCGCCTCCT TTTCCTrCCT TCTTCCTCAC AGCAGGTCTA TAACAGTCAC CCTTGGAGCC CATAACATAA CAGAGGAAGA AGACACATGG CAGAAGCTTG AGGTTATAAA GCAATTCCGT CATCCAAAAT ATAACACTTC TACTCTTCAC CACGATATCA TGTTACTAAA GGTGACAACA CCTCTCTTCT CCCTTTCCAC TTCCCATTCT CCTAAGCTTC TCCTTCAGGT CCTCATTGCC CTGAATT CTrAGGACTT GGCTATAACA TGAAGCTACT CACCCTGTCC CTCCCTGATC ACCTCCAACT GTCCAGAGCC CATTTCGAGG ACTGACAGTC CTCATrCCC TTCACAGTTG AAGGAGAAAG CCAGCCTGAC CCTGGCTGTG GGGACACTCC CCTTCCCATC ACAATTCAAC TTTGTCCCAC CTGGGAGAAT GTGCCGGGTG GCTGGCTGGG GAAGAACAGG TGTGTTGAAG CCGGGCTCAG ACACTCTGCA AGAGGTGAAG CTGAGACTCA TGGATCCCCA GGCCTGCAGC CACTTCAGAG ACTTTGACCA CAATCTTCAG CTGTGTGTGG GCAATCCCAG GAAGACAAAA TCTGCATTTA AGGTGATCCT CCAACTAGGT TTCCTCTCCA AAACTCACTG TTCAGGGACC TGAATGCTCT TAGAAGGAGA TGGGGTCAGC AGGTTGTCAG TCAGGTGACA GGGTGAGCAT CACAGGAATT GCTGTCCTCC CGTGGTCCAA GACAGCCTCT GACCATCCAT TCCAGTCTAC TGCACTGGGG GCATGGGGTG ACTGTGGAGA ATGTGGATGA CGGTCCCAAG AAAGGAAGAA GGGGCATCAG AACTAGATGT ATAAGTGAGG AGCTCCACCT CCTGGGTCTG ACTTTAGGTC TCACTGTGAC TCCAAGCTGG CTGGCAGACA GGAGTGGAGG ACTTCCCGGG CTCACCTTCT TCTCTCTCTC CTCCCCCTAC AGGGAGACTC TGGGGGCCCT CTTCTGTGTG CTGGGGTGGC CCAGGGCATC GTATCCTATG GACGGTCGGA TGCAAAGCCC CCTGCTGTCT TCACCCGAAT CTCCCATTAC CGGCCCTGGA TCAACCAGAT CCTGCAGGCA AATTAATCCT GGATCCTGAG CCAGCCTGAA GGGAAGCTGG AACTGGACCT TAGCAGCAAA GTGTGTGCAA CTCATTCTGG TTCTACCCT GGTTCCCTCA GCCACAACCC TAAGCCTCCA AGAGGTCTCC TACAGGTAAC AGAACTTCA ATAAACTTCA GTGAAGACAC AGCTTCTAGT CGTGAGTGTG TGTCCCTCTC TGCTGCTCTC TTCTCCTGCA CATGTGACCT GATTCCCAGC CCAAGCACCA AGGA CACCGCTCCT GTCAGCCAAC AAATATCCAT TGAGCGACAC CTGTGTCCCA GGTGCTGCTC TGGGCCCTGG GAGAAGTGCA TCAGTGGGCT TGGTAGTAGA GGGTAGGGAT GGAGTGAAGG GTAGGCAGGA AGAATGTCCC CAGGCTGGTA GGAGGTGGGG TGGGGGG'TT CAGTCTCAAA ACTCCCATGA AAACCAGAGA GAAGTCAG AACTCCACCC AAGAGGCTGG GTTTCTAGGG CCCAGAGCTG CCCTCCCCCA CCCTAGAATG GGCTATAAAA GTCCCTTCCC AGCTACGTCC AGAGAAGAGC TGGAGGAAGT GAGAGGTCGG CTGGGGGTCC TCAAAGTGAG AGGGGAGCAG AGGATCCTCC CGTGCAGGCT GTGGATGTCA CTCACTTCCC AGCTGGTGAA GCCTCGCTGC AGAGATGCAT CTGCTCCCAG CCCTGGCAGG GGTCCTGGCC ACACTCGTCC TCGCCCAGCC CTGTGAGGGC ACTGACCCAG GTAATAGTCC CCTAGACAGG CAAGGAGGAG GGAGGGGAAA TGGAAGGGGA AGCACTTGGG TCITGGAGGG GGTCTTGTGG CTTGCTGAAC CCTGAGTCCC CATCTCTTTG AACAGCCTCC CCTGGGGCAG TGGAGACCTC GGTCCTGCGA GACTGCATAG CAGAGGCCAA GTTGCTGGTG GATGCTGCCT ACAATTGGAC CCAGAAGAGG TGGACTTGGG TCTGGGGGCT GCATGGGCCT GGGAGGATCA GT TAATACCTTG TGGGGTCAGG GAGCCCATGT CCCGTGCTGA TGTTATTTCC CCACCAGGTC CGGGCTGTCT CCAACCAGAT TGTGCGCTTC CCCAATGAGA GACTGACCTC CGACCGTGGC CGAGCCCTCA TGTTCATGCA GTGGGGCCAG TTCATTGACC ATGACCTGGA CTTCTCCCCG GAGTCCCCGG CCAGAGTGGC CTTCACTGCA GGCGTTGACT GTGAGAGGAC CTGCGCCCAG CTGCCCCCCT GCTTCCCAT CAAGGTACCT ACCCTCAGCC AATCTCCCAT GCCCTTGTGT GGCCTCCCCC AAAGGCAAGG TGCTGGGGGT GGGGATCTGG AAGACTGGAG CACCATCCTT AAGGAGCTGC CTGTGGAGCT AGGGTATGAG ACAGAGACAC AAG CACTGTCTCC TCTTCCATCT CAGATCCCAC CCAATGACCC CCGCATCAAG AACCAGCGTG ACTGCATCCC TTTCTTCCGC TCGGCACCCT CATGCCCCCA AAACAAGAAC AGAGTCCGCA ACCAGATCAA CGCGCTCACC TCCTTGTGG ACGCCAGCAT GGTGTATGGC AGTGAGGTCT CCCTCTCGCT GCGGCTCCGC AACCGGACCA ACTACCTGGG GCTGCTGGCC ATCAACCAGC GCTTTCAAGA CAACGGCCGG GCCCTGCTGC CCTTCGACAA CCTGCACGAT GACCCCTGTC TCCTCACCAA CCGCTCGGCG CGCATCCCCT GCTTCCTGGC AGGTCAGACA GGGAGGAAGG TGGTGTCTTC CCAGGAAACA GCCATCCCTG GGGTCCCAAC TGGGAAGCAA TGGTGGGATG TGGTGAAGGT ACATGG1TTG GGACCTCAGT ATTAGGCACA CCATAAGCAT GGATCTGTGC AC TGAAGAGATG GAGGTCCAGT GAGGGCCAGG AGTITGGCCC ACCCCGTCTC TCCCATCCCC AGCCCTGGGT CTACCCTGGT AGAAAGACAT TTCTCTGGGA AAGGCTGCAG TAAATCTGAG CTTGGGGT TCAAGGTGAC ACCCGATCAA CGGAAACCCC CAAACTGGCA GCCATGCACA CCCTCTITAT GCGAGAGCAC AACCGGCTGG CCACCGAGCT GAGACGCCTG AATCCCCGGT GGAATGGAGA CAAACTGTAC AATGAGGCTC GGAAGATCAT GGGGGCCATG GTCCAGGTAA GGAGCTCTGC ATCCCAGCAT CCCCC CTTTGTATCT CCACCCACCA ATAGTAAATT AATGTTGTCA CAITTGACGT GATGACAATA AAGAATATGT CTGAGCCACC CTTTGAAAAG GCAAGGGTAT GGGTGAGTAG CCTCTGGGGA ATGTTCCTCC TGTCTTCCCT TCCAGATCAT CACCTACCGA GACTTCTGC CCCTGGTTCT GGGCAAGGCC CGGGCCAGGA GAACCCTGGG GCACTACAGG GGGTACTGCT CCAATGTGGA CCCACGGGTG GCCAATGTCT TCACCCTGGC CTrCCGCTTT GGCCACACAA TGCTCCAGCC CTTCATGTTC CGCTTGGACA GTCAGTACCG GGCCTCCGCA CCCAACTCGC ATGTCCCACT TAGCTCTGCC TTCTITGCCA GCTGGCGGAT CGTGTATGAA GGTGACCAGG TITTCCAGGG GGCAAATGGG GGTGAGGGTG GGGAGCATGC CCTCCCCTAG GTGG TCCAGCTGCT TCATGTCTCT CCAGAACTCT GTTTCCTGAC AAACGTTACT AACATACCCG ACTGGCTTGT CCAGCTCTGG GCTAGCTTGG CATCATGTGA TAACCCAAGT AGCTTCCCAG AGGCTGGTCC AATCTGTGCT GCTCACATTC CCTGCCACCA GGGGGCATCG ACCCCATCCT CCGGGGCCTC ATGGCCACCC CTGCCAAGCT GAACCGTCAG GATGCCATGT TAGTGGATGA GCTCCGGGAC CGGCTGTTTC GGCAAGTGAG GAGGATTGGG CTGGACCTGG CAGCTCTCAA CATGCAACGA AGCCGGGACC ACGGCCTTCC AGGTGAGGGG GCTGTCCACC TCTTCTCCCA GCTGCTCG GGCCAGGCTG CTCAAGGGGT TCTGGGAAGA CCCTGGTACC CGACTGCCTG GTAGGTTCTG GTGGCAGAAA CGAGGTGTTT TCACCAAAAG ACAGCGCAAG GCCCTGAGCA GAA'TTCCTT GTCTCGAATT ATATGTGACA ATACCGGTAT CACCACGGTT TCAAGGGACA TCTTCAGAGC CAACATCTAC CCTCGGGGCT TTGTGAACTG CAGCCGTATC CCCAGGTTGA ACCTATCAGC CTGGCGAGGG ACATGAGGCT TCTGCAGGTA AGGGGAGGCC ACCTCCAGCA CCCTGGGCTG GTTAAGCCTC WO 00/09525 PCTIUS99/17712 ACATCCT'rCC CTGGATGGAT GGCTGAGTCC T=TAGGTCT CTAAGCAGAG AAAACAGAAC flGTCACTAG GTACT=T1C CAAGTGG=T CCCAATGTGC TAGTIrCTGG GCTGACAGTC AATTCCAGGC CCTAGGAC Fr TGGGGGGAAA TITAGGAGCAT CCAACTA GAATTCCGTG GCCAGGACCC CTGCCAGGGC ACTGACCCAG CCTCCCCTGG GGCAGTGGAG ACCTCGGTCC TGCGAGACTG CATAGCAGAG GCCAAGTrGC TGGTGGATGC TGCCTACAAT TGGACCCAGA AGAGCATCAA GCAGCGGCT7 CGCAGCGGTT CAGCCAGCCC CATGGACCTC CTGTCCTACT TCAAACAACC GGTAGCAGCC ACCAGGACAG rGTrCGGGC CGCAGATTAT ATGCATGTGG C'mGGGGCTr GC=GAAGAG AAGTTACAAC CCCAGCGGTC CGGACCCTC ATTGTCACTG ATGTGCTAAC AGAACCACAG CTGCGGCTGC TGTCCCAGGC CAGTGGCTGT GCTCTCCGGG ACCAGGCCGA GCGCTGCAGC GACAAGTACC GCACCATCAC TGGACGGTGC AACAACAAGA GGAGACC=T GCTAGGGGCC TCCAACCAGG CTCTGGCTCG CTGGCTGCCC GCCGAGTATG AGGATGGGCT GTCGCTCCCC TrCGGCTGGA CCCCCAGCAG GAGGCGCAAT GGCTrCCTrC TCCCTCTT7GT CCGGGCTGTC TCCAACCAGA 'FrGTc3CGC= CCCCAATGAG AGACTGACCT CCGACCGTGG CCGAGCCCTC ATGTTCATGC AGTGGGGCCA GT-rCAT-rGAC CATGACCTGG A=TCTCCCC GGAGTCCCCG GCCAGAGTGG CCTICACTGC AGGCGTrGAC TGTGAGAGGA CCTGCGCCCA GCTGCCCCCC TGC=hCCCA TCAAGATCCC ACCCAATGAC CCCCGCATCA AGAACCAGCG TGACTGCATC CCTTC'ICC GCTCGGCACC CTCATGCCCC CAAAACAAGA ACAGAGTCCG CAACCAGATC AACGCGCTCA CCTCCT=GT GGACGCCAGC ATGGTGTATG GCAGTGAGGT CTCCCTCTCG CTGCGGCTCC GCAACCGGAC CAACTACCTG GGGCTGCTGG CCATCAACCA GCGCTTCAA GACAACGGCC GGGCCCTGCT GCCCITrCGAC AACCTGCACG ATGACCCCTG TCTCCTCACC AACCGCTCGG CGCGCATCCC CTGCTTCCTG GCAGGTGACA CCCGATCAAC GGAAACCCCC AAACTGGCAG CCATGCACAC CCT=~lATG CGAGAGCACA ACCGGCTGGC CACCGAGCTG AGACGCCTGA ATCCCCGGTG GAATGGAGAC AAACTGTACA ATGAGGCTCG GAAGATCATG GGGGCCATGG TCCAGATCAT CACCTACCGA GA~cTTCGC CCCTGGTTCT GGGCAAGGCC CGGGCCAGGA GAACCCTGGG GCACTACAGG GGGTACTGCT CCAATGTGGA CCCACGGGTG GCCAATGTCT TCACCCTGGC C=CCGC7FT GGCCACACAA TGCTCCAGCC CT7CATGTC CGCTI'GGACA GTCAGTACCG GGCCTCCGCA CCCAACTCGC ATGTCCCACT TAGCTCTGCC TTCTIGCCA GCTGGCGGAT CGTGTATGAA GGGGGCATCG ACCCCATCCT CCGGGGCCTC ATGGCCACCC CTGCCAAGCT GAACCGTCAG GATGCCATGT TAGTGGATGA GCTCCGGGAC CGGCTGTIC GGCAAGTGAG GAGGATTGGG CTGGACCTGG CAGCTCTCAA CATGCAACGA AGCCGGGACC ACGGCCTTCC AGGGTACAAT GCTTGGAGGC G=1CTGTGG GCTCTCCCAG CCCCGGAATT TGGCACAGCT TAGCCGGGTG CTGAAAAACC AGGACTrGGC AAGGAAGTTC CTGAATrGT ATGGAACACC TGACAACA'F[ GACATCTGGA TlGGGGCCAT CGCTGAGCCT CFFIGCCGG GGGCTCGAGT GGGGCCTC'F CTGGCT-rGTC TGTrCGAGAA CCAGTCAGA AGAGCCGAGA CGGAGACAGG TTCTGGTGGC AGAACGAGGT G'T=rCACCA AAGACAGCGC AAGGCCCTGA GCAGAATI'C CIGTCTCGA ATTATATGTG ACAATACCGG TATCACCACG G=FCAAGGG ACAT=TCAG AGCCAACATC TACCCTCGGG GCTIGTGAA CTGCAGCCGT ATCCCCAGGT TGAACCTATC AGCCTGGCGA GGGACATGAG GCTTCTGCAG GAGTCTATCC CAAGTCTCCA ACTIIGGAG ACAAGGGGAA GGGGAGGACC ATGAGGCTGC C'FGTCTCCC TGGAGCAAGT GCAGGCTCGT GACGCTTCTG CTGGCTACAG CTCAGAGCTG GGTTCCCCAG CCAGGAGTGA AGGCTGGGGG CTCCTATCAG CAATGGACCT TCCGCCT17GG GAGCCTCTTA GGTATTAGGC TATGAATCAG CGCCACGTGC AAAGGCTrGG GAGCCAAGCC ATGTGGTCTr GCACCCCAGG CAAGAAAAGT CAGCTGGAGG GTTTACAGCA CTTCTACTG TICCCAGCC CTCCCTCCCC TCCCTCACCA TGACTAAGAG ACCACTCGGT CCTAGCCTCC AGACACCCCA CAATACTCCT CTGAGCCTGA GGCCAGGCAG CATGCTCTGC TT1CTACCAAT AAAGCACTGC CGGAATTC CATATGTATG GGAATACTGT ATITCAGGCA TrATAAGGAA TGAAATTATA GGCCGGGCAT TGTGGCTAAC CCTrGTAATC CTAGCACTJT GAGAGGCTGA AGTGGGCAGA TCACTTGAGC TIFCAGAGTrC GAGACCAGCA TGGACAACAT GGTGAAACCC AGTCTCTACC AAAAACACAA AAATATrAGC TGGGTGTGGT GGTGCATGCC TGTAGTCCCA GCTACTCAGG AGGCTGAGGT GGGAGGATCG CTrGAGCCTG GGAGGCAGAA G'TrGCAATGA GCAGAGATCG TGCCACTCCG CTCCAGTCTr GGTGACAGAA TGAGACTCCA TCTCAAAAAT AAATAAATAA ATAAATAAAA TAAATGAAAT GAAATTATAA GAAATrACCA CT=~CATG TAAGAAGTGA TCATICCAT TATAAGGGAA GGAA=~AAT CCTACCTGCC ATrCCACCAA AGCTrACCTA GTGCTAAACG ATGAGGTGTT AGTAAGACCA ACATCTCAGA GGCCTCTCTG TGCCAATAGC C'ITCCTTCCT TrCCCTrCCA AAAACCTCAA GTGACTAGTT CAGAGGCCTG TCTGGAATAA TGGCATCATC TAATATCACT GGCC'ITCTGG AACCTGGGCA TMTCCAGTG TG'rrCCATAC TGTCAATATr CCCCCAGCTr CCTGGACTCC TGTCACAAGC TGGAAAAGTG AGAGGATGGA CAGGGATrAA CCAGAGAGCT CCCTGCTGAG GAAAAAATCT CCCAGATGCT GAAAGTGAGG CCATGTGGCT TGGCCAAATA AAACCTGGCT CCGTGGTGCC TCTGTCTfAG CAGCCACCCT GCTGATGAAC TGCCACCTrG GAC1TGGGAC CAGAAAGAGG TGGGTTGGGT GAAGAGGCAC CACACAGAGT GATGTAACAG CAAGATCAGG TCACCCACAG GCCCTGGCAG TCACAGTCAT AAATrAGCTA ACTGTACACA AGCTGGGGAC ACTCCCTrFG GAAACCAAAA AAAAAAAAAA AAAAAAGAGA CCMIATGCA AAAACAACTC TCTGGATGGC ATGGGGTGAG TATAAATACT TCTrGGCTGC CAGTGTGTrC ATAAC'TffGT AGCGAGTCGA AAACTGAGGC TCCGGCCGCA GAGAACTCAG CCTCATrCCT GCTTTAAAAT CTCTCGGCCA CC'ITGATGA GGGGACTGGG CAG TCTAGA CAGTCCCGAA GTFCTCAAGG CACAGGTCTC rTCCTGGTI GACTGTCCTT ACCCCGGGGA GGCAGTGCAG CCAGCTGCAA GGTGAG'ITGC C CATATGTATG GGAATACTGT AT'ICAGGCA ITATAAGGAA TGAAATTATA GGCCGGGCAT TGTGGCTAAC CCTTGTAATC CTAGCACT1T GAGAGGCTGA AGTGGGCAGA TCACTrGAGC TrCAGAG17C GAGACCAGCA TGGACAACAT GGTGAAACCC AGTCTCTACC AAAAACACAA AAATATFAGC TGGGTGTGGT GGTGCATGCC TGTAGTCCCA GCTACTCAGG AGGCTGAGGT GGGAGGATCG CTI'GAGCCTG GGAGGCAGAA GTrGCAATGA GCAGAGATCG TGCCACTCCG CTCCAGTCTr GGTGACAGAA TGAGACTCCA TCTCAAAAAT AAATAAATAA ATAAATAAAA TAAATGAAAT GAAATTATAA GAAATrACCA C'TTMCATG TAAGAAGTGA TCATICCAT TATAAGGGAA GGAA'ITrAAT CCTACCTGCC ATTCCACCAA AGCTrACCTA GTGCTAAAGG ATGAGGTGTT AGTAAGACCA ACATCTCAGA GGCCTCTCTG TGCCAATAGC CTrCCTrCCT TTCCC TCCA AAAACCTCAA GTGACTAG17 CAGAGGCCTG TCTGGAATAA TGGCATCATC TAATATCACT GGCCTCTGG AACCTGGGCA T1TJCCAGTG TGITrCCATAC TGTCAATATI7 CCCCCAGCTT CCTGGACTCC TGTCACAAGC TGGAAAAGTG AGAGGATGGA CAGGGA1TAA CCAGAGAGCT CCCTGCTGAG GAAAAAATCT CCCAGATGCT GAAAGTGAGG CCATGTGGCT TGGCCAAATA AAACCTGGCT CCGTGGTGCC TCTGTC ITAG CAGCCACCCT GCTGATGAAC TGCCACCTTG GACTTGGGAC CAGAAAGAGG TGGG ITGGGT GAAGAGGCAC CACACAGAGT GATGTAACAG CAAGATCAGG TCACCCACAG GCCCTGGCAG TCACAGTCAT AAA ITAGCTA ACTGTACACA AGCTGGGGAC ACTCCC1TJG GAAACCAAAA AAAAAAAAAA AAAAAAGAGA CC I1ATGCA AAAACAACTC TCTGGATGGC ATGGGGTGAG TATAAATACT TCT~rGGCTGC CAGTGTGTrC ATAAC IMGT AGCGAGTCGA AAACTGAGGC TCCGGCCGCA GAGAACTCAG CCTCA TCCT WO 00/09525 PCT/US99/1 7712 hpI-1 09 43 GCTIAAAAT CTCTCGGCCA CCMTGATGA GGGGACTGGG CAGTrCTAGA CAGTCCCGAA GTrCTCAAGG CACAGGTCTC TTCCTGG=~ GACTGTCCTr ACCCCGGGGA GGCAGTGCAG CCAGCTGCAA GGTGAGTrGC C CTGCITAAA ATCT~JrCGGC CACC1TGAT GAGGGGACTG GGCAGTrCTA GACAGTCCCG AAGTrCTCAA GGCACAGGTC TCT~rCCTGGT TTGACTGTCC rrACCCCGGG GAGGCAGTGC AGCCAGCTGC AAGCCCCACA GTGAAGAACA TCTGAGCrCA AATCCAGATA AGTGACATAA GTGACCTGCT TTGTAAAGCC ATAGAGATGG CCTGTCCTTG GAAATTcTG T-rCAAGACCA AATTCCACCA GTATGCAATG AATGGGGAAA AAGACATCAA CAACAATGTG GAGAAAGCCC CCFGTGCCAC CTCCAGTCCA GTGACACAGG ATGACCTTCA GTATCACAAC CTCAGCAAGC AGCAGAATGA GTCCCCGCAG CCCCTCGTGG AGACGGGAAA GAAGTCTCCA GAATCTCTGG TCAAGCTGGA TGCAACCCCA T7GTCCTCCC CACGGCATGT GAGGATCAAA AACTGGGGCA GCGGGATGAC =TCCAAGAC ACA=~CACC ATAAGGCCAA AGGGATITA ACTrGCAGGT CCAAATCT7G CCTGGGGTCC A'FrATGACTC CCAAAAGI7 GACCAGAGGA CCCAGGGACA AGCCTACCCC TCCAGATGAG =TCTACCTC AAGCTATCGA ATT1GTCAAC CAATATFACG GCTCCTrCAA AGAGGCAAAA ATAGAGGAAC ATCTGGCCAG GGTGGAAGCG GTAACAAAGG AGATAGAAAC AACAGGAACC TACCAACTGA CGGGAGATGA GCTCATCTTC GCCACCAAGC AGGCCTGGCG CAATGCCCCA CGCTGCATTrG GGAGGATCCA GTGGTCCAAC CTGCAGGTCT TCGATGCCCG CAGCTGTrCC ACTGCCCGGG AAATGTITGA ACACATCTGC AGACACGTGC GTTACTCCAC CAACAATGGC AACATCAGGT CGGCCATCAC CGTGTrCCCC CAGCGGAGTG ATGGCAAGCA CGACT7CCGG GTGTGGAATG CTCAGCTCAT CCGCTATGCT GGCTACCAGA TGCCAGATGG CAGCATCAGA GGGGACCCTG CCAACGTGGA ATTCACTCAG CTGTGCATCG ACCTGGGCTG GAAGCCCAAG TACGGCCGCT TCGATGTGGT CCCCCTGGTC CTGCAGGCCA ATGGCCGTGA CCCTGAGCTC TF7CGAAATCC CACCTGACCT TGTGCTTGAG GTGGCCATGG AACATCCCAA ATACGAGTGG =~CGGGAAC TGGAGCTAAA GTGGTACGCC CTGCGTGCAG TGGCCAACAT GCTGCITGAG GTGGGCGGCC TGGAG TCCC AGGGTGCCCC TTCAATGGCT GGTACATGGG CACAGAGATC GGAGTCCGGG ACYTCTGTGA CGTCCAGCGC TACAACATCC TGGAGGAAGT GGGCAGGAGA ATGGGCCTGG AAACGCACAA GCTGGCCTCG CTCTGGAAAG ACCAGGCTGT CGTTGAGATC AACATrGCTG TGATCCATAG TITCAGAAG CAGAATGTGA CCATCATGGA CCACCACTCG GCTGCAGAAT CCTCATGAA GTACATGCAG AATGAATACC GGTCCCGTGG GGGCTGCCCG GCAGACTGGA MFGGCTGGT CCCTCCCATG TCTGGGAGCA TCACCCCCGT G'IMCACCAG GAGATGCTGA ACTACGTCCT GTCCCCTFC TACTACTATC AGGTAGAGGC CTGGAAAACC CATGTCTGGC AGGACGAGAA GCGGAGACCC AAGAGAAGAG AGAT7CCA'FT GAAAGTC'rTG GTCAAAGCTG TGCTC'=GC CTGTATGCTG ATGCGCAAGA CAATGGCGTC CCGAGTCAGA GTCACCATCC TCTPGCGAC AGAGACAGGA AAATCAGAGG CGCTGGCCTG GGACCTGGGG GC=TATrCA GCTGTGCCTT CAACCCCAAG G'ITGTCTGCA TGGATAAGTA CAGGCTGAGC TGCCTGGAGG AGGAACGGCT GCTGT7GGTG GTGACCAGTA CG1T7GGCAA TGGAGACTGC CCTGGCAATG GAGAGAAACr GAAGAAATCG CTCTTCATGC TGAAAGAGCT CAACAACAAA TCAGGTACG CTGTG TTGG CCTCGGCTCC AGCATGTACC CrCGGTTCTG CGCC1TGCT CATGACATTG ATCAGAAGCT GTCCCACCTG GGGGCCTCTC AGCTCACCCC GATGGGAGAA GGGGATGAGC TCAGTGGGCA GGAGGACGCC TTCCGCAGCT GGGCCGTGCA AACC=CAAG GCAGCCTGTG AGACG=fGA TGTCCGAGGC AAACAGCACA TTCAGATCCC CAAGCTCTAC ACCTCCAATG TGACCTGGGA CCCGCACCAC TACAGGCrCG TGCAGGACTC ACAGC='~G GACCTCAGCA AAGCCCTCAG CAGCATGCAT GCCAAGAACG TGT7CACCAT GAGGCTCAAA TCTCGGCAGA ATCTACAAAG TCCGACATCC AGCCGTGCCA CCATCCTGGT GGAACTCTCC TGTGAGGATG GCCAAGGCCT GAACTACCTG CCGGGGGAGC ACC'ITGGGGT 'rTGCCCAGGC AACCAGCCGG CCCTGGTCCA AGGCATCCTG GAGCGAGTGG TGGATGGCCC CACACCCCAC CAGACAGTGC GCCTGGAGGA CCTGGATGAG AGTGGCAGCT ACrGGGTCAG TGACAAGAGG CTGCCCCCCT GCTCACTCAG CCAGGCCCTC ACCTACTCCC CGGACATCAC CACACCCCCA ACCCAGCTGC TGCTCCAAAA GCTG1GCCCAG GTGGCCACAG AAGAGCCTGA GAGACAGAGG CTGGAGGCCC TGTGCCAGCC CTCAGAGTAC AGCAAGTGGA AGT7CACCAA CAGCCCCACA T7CCTGGAGG TGCTAGAGGA GTTCCCGTCC CTGCGGGTGT CTGCTGGCT CCTGC1TCC CAGCTCCCCA ITrCTGAAGCC CAGGTTCTAC TCCATCAGCT CCTCCCGGGA TCACACGCCC ACGGAGATCC ACCTGACTGT GGCCGTGGTC ACCTACCACA CCGGAGATGG CCAGGGTCCC CTGCACCACG GTGTCTGCAG CACATGGCTC AACAGCCTGA AGCCCCAAGA CCCAGTGCCC TGC1TGTGC GGAATGCCAG CGCCTTCCAC CTCCCCGAGG ATCCCTCCCA TCCITGCATC CTCATCGGGC CTGGCACAGG CATCGTGCCC TrCCGCAGT7 TCTGGCAGCA ACGGCTCCAT GACTCCCAGC ACAAGGGAGT GCGGGGAGGC CGCATGACCT TGGTGTITGG GTGCCGCCGC CCAGATGAGG ACCACATCTA CCAGGAGGAG ATGCTGGAGA TGGCCCAGAA GGGGGTGCTG CATGCGGTGC ACACAGCCTA TrCCCGCCTG CCT7GGCAAGC CCAAGGTCTA TGTrCAGGAC ATCCTGCGGC AGCAGCTGGC CAGCGAGGTG CTCCGTGTGC TCCACAAGGA GCCAGGCCAC CTCTATGT'1T GCGGGGATGT GCGCATGGCC CGGGACGTGG CCCACACCCT GAAGCAGCTG GTGGCTGCCA AGCTGAAATT GAATGAGGAG CAGGTCGAGG ACTAMITCI TCAGCTCAAG AGCCAGAAGC GCTATCACGA AGATATCTI'C GGTGCTGTAT FrCCTACGA GGCGAAGAAG GACAGGGTGG CGGTGCAGCC CAGCAGCCTG GAGATGTCAG CGCTCTGAGG GCCTACAGGA GGGGT-rAAAG CTGCCGGCAC AGAACT7AAG GATGGAGCCA GCTCrGCAT-r ATCTGAGGTC ACAGGGCCTG GGGAGATGGA GGAAAGTGAT ATCCCCCAGC CTCAAGTCTT ATICCTCAA CG'rTGCTCCC CATCAAGCCC MTACT7GAC CTCCTAACAA GTAGCACCCT GGATTGATCG GAGCCTrCCTC TCTCAAACTG GGGCCTCCCT GGTCCMTGG AGACAAAATC TTAAATGCCA GGCCTGGCGA GTGGGTGAAA GATGGAACI1T GCTGCTGAGT GCACCAC7TC AAGTGACCAC CAGGAGGTGC TATCGCACCA CTGTGTA'I7r AACTGCCTTG TGTACAGTTA ITTATGCCTC TGTAT11FAAA AAACTAACAC CCAGTCTGTT CCCCATGGCC A=TGGGTCT TCCCTGTATG ATrCCITGAT GGAGATA=F ACATGAATTG CA=1TA=F TAATC GAATTCCCAC TCTGCTGCCT GCrCCAGCAG ACGGACGCAC AGTAACATGG GCAACTTGAA GAGCGTGGCC CAGGAGCCTG GGCCACCCTG CGGCCTGGGG CTGGGGCTGG GCCTTGGGCT GTGCGGCAAG CAGGGCCCAG CCACCCCGGC CCCTGAGCCC AGCCGGGCCC CAGCATCCCT ACTCCCACCA GCGCCAGAAC ACAGCCCCCC GAGCTCCCCG CTAACCCAGC CCCCAGAGGG GCCCAAGTrC CCTCGTGTGA AGAACTGGGA GGTGGGGAGC ATCACCTATG ACACCCTCAG CGCCCAGGCG CAGCAGGATG GGCCCTGCAC CCCAAGACGC TGCCrGGG~T CCCTGGTATT TCCACGGAAA CTACAGGGCC GGCCCTCCCC CGGCCCCCCG GCCCCTGAGC AGCTGCTGAG TCAGGCCCGG GACTTCATCA ACCAGTACTA CAGCTCCATT AAGAGGAGCG GCTCCCAGGC CCACGAACAG CGGCT1rCAAG AGGTGGAAGC CGAGGTGGCA GCCACAGGCA CCTACCAGCT TAGGGAGAGC GAGCTGGTGT TCGGGGCTAA GCAGGCCTGG CGCAACGCTC CCCGCTGCGT GGGCCGGATC CAGTGGGGGA AGCTGCAGGT GITCGATGCC CGGGACTGCA GGTCTGCACA GGAAATG7C ACCTACATCT GCAACCACAT CAAGTATGCC ACCAACCGGG GCAACCTCG CTCGGCCATC ACAGTGTTrCC CGCAGCGCTG CCCTrGGCCGA GGAGACTrCC GAATCTGGAA CAGCCAGCTG GTGCGCTACG CGGGCTACCG GCAGCAGGAC GGCTCTGTGC GGGGGGACCC AGCCAACGTG GAGATCACCG AGCTCTGCAT TCAGCACGGC TGGACCCCAG GAAACGGTCG CT7CGACGTG CTGCCCCTGC TGCTGCAGGC CCCAGATGAG CCCCCAGAAC TcTICCTCT GCCCCCCGAG CTGGTC=TG AGGTGCCCCT GGAGCACCCC ACGCTGGAGT GGTITGCAGC CCTGGGCCTG CGCTGGTACG CCCTCCCGGC AGTGTCCAAC ATGCTGCTGG AAATrGGGGG CCTGGAGTTC CCCGCAGCCC CCT7CAGTGG CTGGTACATG AGCACTGAGA TCGGCACGAG GAACCrGTGT GACCCTCACC GCTACAACAT CCTGGAGGAT GTGGCTGTCT GCATGGACCT GGATACCCGG WO 00/09525 PCTIUS99/17712 EeI-109 44 ACCACCTCGT CCCTGTGGAA AGACAAGGCA GCAGTGGAAA TCAACGTGGC CGTGCTGCAC AGTTACCAGC TAGCCAAAGT CACCATCGTG GACCACCACG CCGCCACGGC CTC'TCATG AAGCACCTGG AGAATGAGCA GAAGGCCAGG GGGGGCTGCC CTGCAGACTG GGCCTGGATC GTGCCCCCCA TCTCGGGCAG CCTCACTCCT GYTTCCATC AGGAGATGGT CAACTATTTC CTGTCCCCGG CCTrCCGCTA CCAGCCAGAC CCCTGGAAGG GGAGTGCCGC CAAGGGCACC GGCATCACCA GGAAGAAGAC CTTAAAGAA GTGGCCAACG CCGTGAAGAT CTCCGCCTCG CTCATGGGCA CGGTGATGGC GAAGCGAGTG AAGGCGACAA TCCTGTATGG CrCCGAGACC GGCCGGGCCC AGAGCTACGC ACAGCAGCTG GGGAGACTCT TCCGGAAGGC TTTTGATCCC CGGGTCCTGT GTATGGATGA GTATGACGTG GTGTCCCTCG AACACGAGAC GCTGGTGCTG GTGGTAACCA GCACAT1TGG GAATGGGGAT CCCCCGGAGA ATGGAGAGAG CTTTGCAGCT GCCCTGATGG AGATGTCCGG CCCCTACAAC AGCTCCCCTC GGCCGGAACA GCACAAGAGT TATAAGATCC GCTTCAACAG CATCTCCTGC TCAGACCCAC TGGTGTCCTC TTGGCGGCGG AAGAGGAAGG AGTCCAGTAA CACAGACAGT GCAGGGGCCC TGGGCACCCT CAGGTTCTGT GTGTTCGGGC TCGGCTCCCG GGCATACCCC CACTTCTGCG CCTTGCTCG TGCCGTGGAC ACACGGCTGG AGGAACTGGG CGGGGAGCGG CTGCTGCAGC TGGGCCAGGG CGACGAGCTG TGCGGCCAGG AGGAGGCCTT CCGAGGCTGG GCCCAGGCTG CCTTCCAGGC CGCCTGTGAG ACCTTCTGTG TGGGAGAGGA TGCCAAGGCC GCCGCCCGAG ACATCTTCAG CCCCAAACGG AGCTGGAAGC GCCAGAGGTA CCGGCTGAGC GCCCAGGCCG AGGGCCTGCA GTTGCTGCCA GGTCTGATCC ACGTGCACAG GCGGAAGATG TTCCAGGCTA CAATCCGCTC AGTGGAAAAC CTGCAAAGCA GCAAGTCCAC GAGGGCCACC ATCCTGGTGC GCCTGGACAC CGGAGGCCAG GAGGGGCTGC AGTACCAGCC GGGGGACCAC ATAGGTGTCT GCCCGCCCAA CCGGCCCGGC CTTGTGGAGG CGCTGCTGAG CCGCGTGGAG GACCCGCCGG CGCCCACTGA GCCCGTGGCA GTAGAGCAGC TGGAGAAGGG CAGCCCTGGT GGCCCTCCCC CCGGCTGGGT GCGGGACCCC CGGCTGCCCC CGTGCACGCT GCGCCAGGCT CTCACCTTCT TCCTGGACAT CACCTCCCCA CCCAGCCCTC AGCTC'TGCG GCTGCTCAGC ACCTTGGCAG AAGAGCCCAG GGAACAGCAG GAGCTGGAGG CCCTCAGCCA GGATCCCCGA CGCTACGAGG AGTGGAAGTG GTTCCGCTGC CCCACGCTGC TGGAGGTGCT GGAGCAGTTC CCGTCGGTGG CGCTGCCTGC CCCACTGCTC CTCACCCAGC TGCCTCTGCT CCAGCCCCGG TACTACTCAG TCAGCTCGGC ACCCAGCACC CACCCAGGAG AGATCCACCT CACTGTAGCT GTGCTGGCAT ACAGGACTCA GGATGGGCTG GGCCCCCTGC ACTATGGAGT CTGCTCCACG TGGCTAAGCC AGCTCAAGCC CGGAGACCCT GTGCCCTGCT TCATCCGGGG GGCTCCCTCC TTCCGGCTGC CACCCGATCC CAGCTTGCCC TGCATCCTGG TGGGTCCAGG CACTGGCAITT GCCCCCTCC GGGGATTCTG GCAGGAGCGG CTGCATGACA TTGAGAGCAA AGGGCTGCAG CCCACTCCCA TGACTTGGT GTTCGGCTGC CGATGCTCCC AACTTGACCA TCTCTACCGC GACGAGGTGC AGAACGCCCA GCAGCGCGGG GTGTFTGGCC GAGTCCTCAC CGCCTTCTCC CGGGAACCTG ACAACCCCAA GACCTACGTG CAGGACATCC TGAGGACGGA GCTGGCTGCG GAGGTGCACC GCGTGCTGTG CCTCGAGCGG GGCCACATGT TTGTCTGCGG CGATGTTACC ATGGCAACCA ACGTCCTGCA GACCGTGCAG CGCATCCTGG CGACGGAGGG CGACATGGAG CTGGACGAGG CCGGCGACGT CATCGGCGTG CTGCGGGATC AGCAACGCTA CCACGAAGAC ATI'CGGGC TCACGCTGCG CACCCAGGAG GTGACAAGCC GCATACGCAC CCAGAGC'T TCCTTGCAGG AGCGTCAGTT GCGGGGCGCA GTGCCCTGGG CGTTCGACCC TCCCGGCTCA GACACCAACA GCCCCTGAGA GCCGCCTGGC TCCCTrCC AGTTCCGGGA GAGCGGCTGC CCGACTCAGG TCCGCCCGAC CAGGATCAGC CCCGCTCCTC CCCTCITTGAG GTGGTGCCTT CTCACATCTG TCCAGAGGCT GCAAGGATTC AGCATTATTC CTCCAGGAAG GAGCAAAACG CCTCTTCC CTCTCTAGGC CTGTrGCCTC GGGCCTGGGT CCGCC'AAT CTGGAAGGCC CCTCCCAGCA GCGGTACCCC AGGGCCTACT GCCACCCGCT TCCTGTTTCT TAGTCCGAAT GTTAGATTCC TCTTGCCTCT CTCAGGAGTA TCTTACCTGT AAAGTCTAAT CTCTAAATCA AGTATTTATF ATFGAAGATT TACCATAAGG GACTGTGCCA GATGTTAGGA GAACTACTAA AGTGCCTACC CCAGCTC-3' (SEQ. ID NO:2410) Human Factor Related Anti-sense Oligonucleotide 5'-CCT CCT TCC TGG TCT GTC TGC CBG BCB BBT TTG GGB BGT GBB CBG TTT TGG BBC CBT GTT TCC CBG TCT CTG BGC TGT GGC GCC CTG CTG CrC TTT CTG CT TCC CTT GGT GGG TTG GGC C GCT GGT TGT TCT GGG GTr C TTG CTG CCC CTT CTG TCC C TGT TTG CTG GTG TCT GCG C CCC CBB CBG BBG BBG CBG BCB BBT TG GGB BGT GBB CBG TTT TGG BBC CBT GTT TCC TGT GCG CTC GGC CTG GTC CCG G GGG TCT CCT CTT GTT GTT GC TTG CGC CTC CTG CTG GGG GT CC CTC TGT TCT TGT TIT GGG GGC GGG CCC GGC CGT TGT CTT G GTT TGG GGG TTT CCG TTG GGG TTC TCC TGG CCC GGG CCT TGC CC GGC CGT GGT CCC GGC TTC GTTCCT GTC TCC GTC TCG GCT CTT CTG GGG CCT TGC GCT GTC T1 GGT G GCB CCG TCC BGT GBT GGT GCG GTB CTT GTC GCT GCB GCG CTC GGC CTG GTC CCG GBG BGC GCG CGG GCC GGG GGC TGC TGG G GGT TGG CCC GGG GTG CCC C GCC GCT GGG TGC CCT CGT CCT CTG CGG TC GTG TCT CCT GGC TCT GGT TCC CC GCT GCG CCC GTT GTC CTC TGG GGT GGC CTT C GCT CCC GGG TCT GGT TCT TGT GT TGG GGG TCC CF TT GGG CCT GTT GT GGC GTG GCT TGT GTG TC GGT TTC TGC CCT GTC CTC CGG CGT CCC CGG BGC CTC CCC GGG GCB GGB TGB CTT TG BGG GGG BCB CBG BTG TCT GGG CBT TGC CBG GTC CTG GGB BCB GBG CCC CGB GCB GGB CCB GGB GTG CGG GCB GCG CGG GCC GGG GGC TGC TGG GBG CCB TBG CGB GGC TGB G CCT CTT TITC TGT TTT TCC C CTC TGC CT TGT TG GGT TCG CTT CCT TTC TGC TTC TTC C CTG TGT CTC CTG TCT CCG CTT TIT TCr TC GTC TTIT GTTGTO 2TC TCT TCC TG CTG BGC BBG BTB TCT BGB TTC TGG GGT GGT CTC GBT TTT BBBB GCT TGB GBB GCT GCB BBC BTT BTC CBB BGT BTB TTM GBG GCT CCB BGG BTC BCG BCC BTC TTC CCB GGC BTT TTB BGT TGC TGT CGT BBG TGB GBG CTG BGB GBB BCT GTG BBG CBB TCB TGB CTT CBB GBG TTC Tr TCB CCC GTT CIT GGC TTC TTC TGT C CGT TGG CT CTC GIT GTC CC TGT GGG CT CTC GTT GTC CC CCC 'TC GGG GGC TGG TGG GGC CGT CCr TGC CTG CTG G GTT CTT GGC TTC TTC TGT CCG T TGG CTT CTC GT GTC CC TGT GGG CT CTC GT' GTC CC CCC TTC GGG GGC TGG TGG GGC CGT CCT TGC CTG CTG G Tr TCT CTT TCG CTT TCT TTT CGT CTC CTG TTC CTC C=T TT TTG CrG TTT TTI CTC CT= CTT CTC TCC TTT CTT TTC T TCT CTT TCG CIT TCT TTT CGT CTC CrG TIC CTC CTT TT TTG CTG TTT TTT CTC CTT CTT CTC TCC TTT CIT TC CTC TGT CIT GTT CTG GTC CTT CGT GGG GCT CTG TGT CGC GTG G GTG CGG CCG TGG CC GGC GGB CCB GGB GTT GGB GCB GGB GCB GGB CGG GCB GGC GGC TCB TGT TTG GBT CGG CBG GBG GCB CrC CTC TGG TTG GCT TCC T7C GCC GGC BCB TGC TBG CBG GBB GBB CBG BGG GGG BBG CBG TG GGB GGT GBG BCC CBT TBB TBG GTG TCG B TCCCTGTTIC CCCCCTTTCG TTCTGCGTTT GCCTFIGGCG 11ITlITTIT GTTTTCTCTC TCCGTCTC TTCTCCCCT GTGGGBBTTT CTGTGGGGBT GGCBTBCBCG TBGGCBGCTC CBBGBGCTBG CBBBCTCBBB TGCBGBBGCB TCCTCBTGGC TCTGBBBCGG TGGGAATTTC TGTGGGGBTG GCATACACGT AGGCAGCTCC AAGAGCTAGC AAACTCAAAT GCAGAAGCATC CTCATGGCTC TGAAACG GGGGGTGGCT TCCTGCCGCG TCTCrGGGCC GTCCCGTCCC TCGGCCCCGC GCCGCGCTCG GCTCCrCTCC CTCTGGCCCG GCTCGGGGCG GGGCGGGGCG GTGGGCGGGC GGCGCTGCCC TGCGCGCGGC GCTGGCCCCT GCTGGCCGTC GGCTGCGCGC TGCTGGCTGC CCTGCTGGCC GCGCCGGGGC CTGTCCGCCT CTGCGGGCGC TGTCTCCTGG CTTGTCTTCC GGCTCTTCTG CTGGGGTGGG GCTGGGCGGC WO 00/09525 PCT/US99/17712 izI-109 45 CGGCCCGGTG CTGGGGCTCC TCGGGGGGGG GGGCTCTTCC GGGCTGTCTC CCTCCGGGGC GGGGGTTTCT GGCCGTGGGG GTCTTGCCTG GCCTCCGGGC TCCTGCTTGT CTTGCCTTCC TTCTCTGGTC GGTTGTGGCT CGGGGCTCCG TGGGTCCCTG GCGCCCGTTT GTGTTTTGTC TTTTCCCCTG GCGTCCCTGT GCCCCTCTCC TCTCCTTCCT CTGCTTCTCG CTCTCCTTTG TGGGGCCCTC CCTGCTGCTC TTGGTTTTGG GC111TITC TCTTCCTCCT TTTTCGTGCG TGGGCCTCC GCACGCCTCT TGCCACCTCC TGCGCAGGGC AGCGCCTTGG GGCCAGCGCC GCTCCCGGCG CGGCCAGCAG GGCAGCCAGC AGCGCGCAGC CGACGGCCAG CATGCTTCCT CCTCGGCTAC CACTCCATGG TCCCGCAGAG GCGGACAGGC GCBCGCCTC TTGCCBCCTC CTGCGCBGGG CBGCGCCTTG GGGCCBGCGC CGCTCCCGGC GCGGCCBGCB GGGCBGCCBG CBGCGCGCBG CCGBCGGCCB GCBTGCTTCC TCCTCGGCTB CCBCTCCBTG GTCCCGCBGB GGCGGBCBGG C GGGGTGGBBB GGTTTGGBGT BTGTCTTTBT GCBCTGBCBT CTBBGTTCTT TBGCBCTCCT TGGCBBBBCT GCBCCTTCBC BCBGBGCTGC BGBBBTCBGG BBGGCTGCCB BGBGBGCCBC GGCCBGCTTG GBBGTCBTGT TrBCBCBCBG TGBGBTGGTT CCTTCCGGGC TTGTGTGCTC TGCTGTCTCT TGGTTCCTTC CGGTGGTTTC TTCCTGGCTC TTGTCCTTTC TCTTGG CCCT TGGC CGGGBGTGGG GGTCCTGGBC GGCBCTGBBG GCBTCCBGGG CTCCCTTCCB GTCCTTCTTG TCCGCTGCCB GCBCCCCTTC BTTCCBGBGG CTGBTGGCCT CCBCCBGGGB CBTGBTrBGG TBGBBBCTBG GBGGCCGGCC TCCBCCBGGG BCBTGGTCCT TCTTGTCCGC TGCCTCTCTG GGGTTTCGG TCTGGGTGGG CTTTCCTCCT GGGGCTGCTG CTGGGCTCTT CIT1TGTTT CTGGCCTGGT GCTCTCTCGT GCCCTTTCCC TTGGGTGTCT TGTTTT1GTG GCCTCCBCCB GGGBCBTG GTCTTTGTTT CTGGGCTCGT GCCCCBTCCC GGCTTCTCTC TGGTTCCGTC CTCTGTGGTG TITGGCCCTG CTTCCTTITG CCTGTTGAGG GGGCAGCAGT TGGGCCCCAA AGGCCCTCTC GTT'CACCTTC TGGCACGGAGTT GCATCCCCATA GTCAAACTCT GTGGTCGTGT CATAGTCCTC TGTGGTGTTT GGAGTMTCCA TCCCGGCTTC TCTCTGGTTC CAAGGGAGB GGGGGCBGCB GTTGGGCCCC BBBGGCCCTC TCGTTCBCCT TCTGGCBCGG BGTTGCBTCC CCBTBGTCBB BCTCTGTGGT CGTGTCBTBG TCCTCTGTGG TGTTTGGBGT TTCCBTCCCG GCTTCTCTCT GGTTCCBBGG GB GGGCBCGGGG CBGTGGGCGG GCBBTGTBGG CBBBGCBGCB GGGTGTGGTG TCCGBGGBBT BTGGGGBGGC BGBTGCBGGB GCGCBGBGGG CBGTBGCBBT GBGGBTGBCB GCGBGGCGTG CCGCGGBGBC CTTCBTGGTB CCTGTGGBGB GGCTGTCGGB GGGGGTGTGG TGTCCGCTTG GCGGTTCTTT CGGGTGTTITC TTCTCTGGGT TGGCCTGCTG CTCGTCGTGGT CGCTCCGCTC CCGGGTT'CGT CTCGCTCTGT CGCCCCTTCC TTCCTTGTCG TGTTCCTCCC TTCCTTGCCT CT GBTGTTGTT BCCBBBGCBT CBBGBBTBGC TTT'GCTBTCT BBGGBTCBCB TTTBGBCBTB GGBBBBCGCT GTBGGTCBGBB BGBTGTGCTT BCCTTCBCBC BGBGCTGCBG BBBTCBGGBBGG CTGCCBBGBGBG CCBCGGCCBGC TTGGBGTCBT GTTTBCBCBC BGTGBGGTGC TCCGGTGGCT TTTTGCTTGT GTGCTCTGCT GTCTCTG TTC CTTCCGGTGG TTTCTTCCTG GCTCTTGTCC TTTCTCTTGG CCCTTGGCCC CTTGBGCBGG BBGCTCTGGG GCBGGGBGCT GGCBGGGCCC BGGGGGGTGG CTTCCTGCBC TGTCCBGBGT GCBCTGTGCC BCBGCBGCBG CTGCBGGGCC BTCBGCTTCB TGGGGCTCTG GGTGGCBGGT CCBGCCBTGG GTCTGGGTGG GGCTGGGCTG CBGGCTCCGG GCGGTCCBGCCBTGGGTCTG GGGGCTGGG CTGCBGGCTC CGGGCGGGCG GGTGCGGGCT GCGTGCTGGG GGCTGCCCCG CAGGCCCTGC GGTCCBGCCB TGGGTCTGGG GGCTGGGCTG CBGGCTCCGG GCGGGCGGGT GCGGGCTGCG TGCTGGGGGC TGCCCCGCAG GCCCTGC GCBCCGCCTG GBGCCCTGGG GCCCCCCTGT CTTCTTGGGG BGCGCCTCCT CGGCCBGCTC CBCGTCCCGG BTCBTGCTTT CBGTGCTCBT GGTGTCCTT CCBGGGGBGB GBGGGGCTGG TCCTCTGCTG TCCTTGCTGG TGCTCBTGGT GTCCTTTCCG CCCTGGGGCC CCCCTGTCTT CTTGGGGCCT CTTCCCTCTG GGGGCCGTCT CTCTCCCTCT CTTGCGTCTC TCTCTTTCTC TCTCTCTCTT CCCCTTTCCC GCTCTTTCTG TCTCGGTGTC TGGTT!TCTC TCTCCGCTGG CTGCCTGTCT GGCCTGCGCT CTTGGCCTGT GCTGTTCCTC CTCCGGTTCC TGTCCTCTCT GTCTGTCGCC CCCTCTGGGG TCTCCCTCTG GGTGGTGGTC TTGTTGCTTG GGCTGGGCTC CGTGTCTCCB GTGCTCBTGG TGTCCGCTGB GGGBGCGTCT GCTGGCGCTG GTCCTCTGCTGTC CTTGCTGGTG CTCBTGGTGT CCTTTCCGCC CTGGGGCCCC CCTGTCTTCT TGGGGCCTCT TCCCTCTGGG GGCCGTCTC TCTCCCTCTC TTGCGTCTCT CTCTTTCTCT C!'CTCTCTTC CCCTTTCCCG CTCTTTCTGT CTCGGTGTCT GGTTTTCTCT CTCCGCTGGC TGCCTGTCTG GCCTGCGCTC TTGGCCTGTG CTGTTCCTCC TCCGGTTCCT GTCCTCTCTG TCTGTCGCCC CCTCTGGGGT CTCCCTCTGG CGTGGTGGTC TTGTTGCTT'G GGCTGGGCTC CGTGTCTCCB GTGCTCBTGG TGTCCGCTGB GGGBGCGTCT GCTGGC CTGCTGBGGC TTGGGTCTCC GGGCGBTTCT CTGCBGBBGB TGCTCBBBGG GCTCCGGCBG TTCCTCCTTG BTCTGGTCGCT GTCGTBCCBG TCGGBCCBGT BBTTCBGBTC BTCBTTGGCT CCTBTTCIT CTGCBBBCBG CTGBGTGGBG BCBBGBBBBB BGBCTGCCBB GGCCBCGBGG BTTTTCBTGT TGGBTITGC GBCGGBCBGT CCCGCGGGGT GCTGAGTTTC TCTGGTTCCT CCGBGCGCBC GTGGTCGCTC CGCGTITCTC TGGTTCCTCC GGTCCCGCGG GGTGCTGTCT GGTCGCTGTC GTGGCTTGGG TCTCCGGGCG GTTTCCTTCC TTITCCGC CGGCCCTTCT CACTGGAGGC ACCGGGCAGT CCTCCATGGG AGGGTTGGGC TTGGCCGGGG CTGCCCGGTG CCTCCTCTTG GCTGGTCCCT CGTTGTCCTT GGGCCCCGC TCCCGCTGCT CGGCCTCCGT GTTCTTTGGC CTCTTGCT'CC GCCTGCTGTC TTGTCCCGTC CCCTCCTCGC TT'GCGTTTCC CTCTTCCTTG TCTTCCAGGC CTTCCTCCGC TrCCGCTGCT GGGGCCCGCG CCGGGGGGGC GCTCGGCTCC GCGGCTITCCT CCCCGGCTGG GGGGTCCTGG TCTCCGGGGC CTGCGGCTCG CGGGCTCGGG GCTGCGTGCG CCGCGCGCGG CGTCCGCGGT GGGTGGCGCT GTCCCGCCGT GGTGTGTCTC CGTTCTCGTC CTGCGCCGTC CTGGTCTGCC CGTGGGGTCC TGGGCGTGGT GGGGGGCGTC TGGTGCCTCG TCTGCCCCGT GGGGCTTCGG GCTCGGGGCT GTTCGTCCCC CCTGCCGCTC TGTGGCCTCC GGGGCTCCTC GTTTTCGCTG CTTCGGGTGT CCTTCTCGGC GTGTGGCCCC GGGTCCCGGC CCTGCTGGGC TGGGCGGGGT CGCTGCCCTG GGCTTCTGGC CCGTCTGGTT GTCTGTCGGT GCTTGTCTCG GGTTTCTGGC CTCTGTGCTG GGCGCTTCTC TGCCTCCTGC TCCGCCCTCC TGGTGGCTCG GCTGGGGGTG CCCGTGCGGG GGTGGGTGTG GGGTGTTTTC GGGGTCCTCC CCTTCCC GTT TCA TCT TGG CTT TAT CCTCT CCC CTT GTT CCT CCC CTCT CCT GCT CTG GRG TCT CCT C TTC CCT CCC TCC CCT GCC GTG TTG TCT GTG GGT GTC GTT TCG CTC TTG TTG CCC TGG GCC CTT CCC TGC TGG GGG GGA GTT TCA TCT TGG GTT TCB TCT TGG CTT TBT CCTCT CCC CTT GTT CCT CCC CTCT CCT GCT CTG GRG TCT CCT C TTC CCT CCC TCC CCT GCC GTG TTG TCT GTG GGT GTC GTT TCG CTC TTG TTG CCC TGG GCC CT! CCC TGC TGG GGG GGB GTT TCB TCT TGG GGG GGB GTT TCB TCT TGG CTT T CCGTGTTGTC BGTGGTGCTG CCCGTTTGBG GTBTGGCGCT CCBCCBBTTC CCTTTTCTCC TTGTTTTCCG TTTCTCTTGC CGTCTGTGGT T GCTCAGCCTC CAAAGGAGCC AGCCTCTCCC CAGTTCCTGA AATCCTGAGT GTTGCCTGCC AGTCGCCATG AGAACTTCCT ACCTTCTGCT GTITACTCTC TGCTTACTTT TGTCTGAGAT GGCCTCAGGT GGTAACTTTC TCACAGGCCT TGGCCACAGA TCTGATCATT ACAATTGCGT CAGCAGTGGA GGGCAATGTC TCTATTCTGC CTGCCCGATC TTTACCAAAA TTCAAGGCAC CTGTTACAGA GGGAAGGCCA AGTGCTGCAA GTGAGCTGGG AGTGACCAGA AGAAATGACG CAGAAGTGAA ATGAAC1TT TATAAGCATT CITTAATAA AGGAAAATTG CTI'TTGAAGT AT ATCCITTTAAG TCAATGGACT TTGCATCAGT CACACCATCT TTTGTTACTT TGGACTTCCC CAGCTATGTT CAATAATTAC TGTTCTTCCC TTGGGCCCCA TTGTAATGGC TACAGCCTCG ACAAAAAGTC TACACTTTGA AGCATTAAGG CTCGGACATC AGCACCAAAT TTTACATCTT TACCATCACT TCAAGTGAGG TGAGGAGCCA GTAGCCTGGA CACTGGTCTC ATCTGGTGAA AGACTGTGGG TAATGGAAGC ATTTCTGTGG GGTGCTGGCA GGACATGTGC ATGGCGAGGC AGGTCATCAG WO 00/09525 PCT/US99/17712 EPI-109 46 CAGCAAGTGA GAGCTGCCTC TTAC=CTA AAGGTGACAT AGCAAATATA CAAAAAAAAA TAAATAAATT ATTAATTTAG GTAGAGCACA TAAAGGCTTr ATTTCATATT CCATTTCTCT GTATGCTTTC TrCACCAGGA AGAAATAGTT TTAGTGTCAG GAATGAATGA GTCTGCCCCT CAATTCCAGC CTGCTCAACA CACAAGGAAA CAAAGCCCrG ACAATCAGAG TGACTCCCTG GTGACTAAGC TCCCAGTCCT GGATGCATAT TTGTTAGCA GTTCTGACAG CATTTGACCC AGCCCTCTCT CTGCATATCC CATCAGAACC TTLITIT TFFI-ITCTT TGAGACTGAG TCTTGCTCTG TCGGAAGCGA CTCCTGTGCC TCAGCCTCCC AAATACCTGG AATTATAGGC GTAAGCCATC ATGCCTGGCT AA'T IITIGTA 17iTCATGG AGATGGGGTT TTGCCATGTT GGTCAAATTG GTCTCACACT CCTGACCTCA TGTGATCCAC CTGCCTCAGC CTCCCAAACT GCTGGGATGA CAGGTGTAAG CCACCATGCT AGGCTCAGAA ATTCCTIT ATAAAAATGT CATTAAGGAT CTTGGCTGCA CAATATCGTT ACCAGCTTCC TTTAAATCCA CTTCTGGCCT GCCAGGAATC AGGTTCTTCA GAACCTGACA ITPTAAATGA AGAGGTCAGG CAGTTCATGA GGAAAGCCTC ATTGTCCCCA TGTCTCTGTC ACTGCTGCAC CCCTGAGACA TCACAGACAT GGACACTGGG GCCTGCTTGT TTCTCAAACT GCCCTTAGAT CGAAAGAGGG AGGAACCAGG ATGAATGCCA CTCATTTCC CAAGAAAGGC CCTCTCCTGA GTGCCCGGGA TGGGGCTCTG TCCATTGCCT GGGGCCGCCA ATTGCTACTC TGGGTTACGG AGGAAGGACA GGGTCCTGAG AGACACCAGA GACCTCACAC AGCCCTGAAA ACATGGGGCT CCTTCATAAG TG'TTCCCAT CACCAACAGG GAGACCACGT GGAGGCCTTG CAGCCCCACT CGGTGCTTCT CCACCAAATC CCAAGGGCAG TGACGCTGAC GTCTGTGGAA AGCAGAGAAA GCCCTGGCTC CCAAAGCCCT GAAGTCCCTG TGGAGCTGAC ATTCCCTGAG TGACGGTGTG AATGGAAGGA ACTCAAGTGC GGGTGGTAGG CCACCTCCTG GCCCAGGCCT GGGTGAACTC TGAGGGGACA CATGTAGTCA CAATCCCATC CTCCCATTCT CCTTCTCAGA GGAAGGAAGT GGGCATCCAT CTGCCTCATC TCTCTCCCGT GGGGAAGATG GGGAG'ITCA GGGGAACT CACATAAATT TCACCAGCTC AGATCTCCTG TGAGGATGGG GCCCACCATG CTCCCGGTGC TGCCAGAGGC CCTGAGCCCC TCCCAGGGTC CCTGGG'TTG AGCCAGCCCT GTATCATCCC CAGGAGCTGA ATGTCAGAGC AATGGATAGA ATTAGATGGA AAGAGCTCTC AA'TTGACCT GAGACTGTCC CCAGATACTC AGGAAAAACA GGACGTCGCA CAGAGTGGGC AGCAGGTGAG TGGCAGGTTA TAGGTCCTGA GTTGAGTI GTTCTCACGT GAGACAGACC CAGCCCCTCA CTCCATTCAC ACACTGGGTT TTAAATGGTG CAAGATAGGA GCAATICT GGTCCCAAGA GCAGGAGGAA GGGA=ITiCT GGGGTTTCCT GAGTCCAGAT TTGCATAAGA TCTCCTGAGT GTGCATGTr CTGAGGAC CATTCTCTGA CTCACCAGGT AAGTGGCTGA ATTCTAACCT CTGTAATGAG CATTGCACCC AATACCAGTT CTGAACTCTA CCTGGTGACC AGGGACCAGG ACCTTATAA GGTGGAAGGC TTGATGTCCT CCCCAGACTC AGCTCCTGGT GAAGCTCCCA GCCATCAGCC ATGAGGGTCT TGTATCTCCT CTTCTCGTTC CTCTTCATAT TCCTGATGCC TCTTCCAGGT GAGATGGGCC AGGGAAATAG GAGGGTTGGC CAAATGGAAG AATGGCGTAG AAGTTCTCTG TCTCCTCTCA TrCCCCTCCA CCTATCTCTC CCTCATCCCT CTCTCTCCTT CCTCTCTCTG TGTGTCCCCT CCATCCTITi CTCCTGCTTC TCTCTCTTCT TCCCTCTCTC TC'nTITrCT GTCTCTIT TTCCTCTCTC CCTAGAGCAT GTC=TCTTT CTrCTCTTT CCTIrCTrCT ACCCACACTT TTAGACTGAA TGCCCTATTT AATTGAACAA AGCATTGCTIT CCTTCAATAG AAAAGGAGTr TGAGAACCCA ATGGACACCT CACTCGTTCT TCTAAGCCAA TATGAAGGAG CCCAGTAGCT TGTAAATATC ATCTCTTCAC TGCTTTCCAT GCTACAACTG CTGAGACTAT GGTTGAAACC TGTrAGGTGA CIT-ITAAAT AAAAGGCAGA AATITTGATT TTATCTAAAG AAAGTAGTAT AGAATGTCAT TITCTAAATT TTTATATT7A AAGGGTAGAT ACTGCAACCT AGAGAATTCC AGATAATCTT AAGGCCCAGC CTATACTGTG AGAACTACTG CAGCAAGACA CTCTGCCTCC AGGACTITC TGATCAGAGG CCCTGAGAAC AGTCCCTGCC ACTAGGCCAC TGCAGGTTCA CAGGACAGGG TACAGCCCAT TGAAACCTAC T7TTAAACCT GGATGCCTAA CCTTCATlT CTCCTTGATA TTATGAAAAT AAAATAAAAA CCATGAAAGG ATAAAAGAGG GAGAGTGGAA GGGAAGGATG GAGAAAGGGA AAAAGAAAAT TTGAGAGTAA ATCCTAAAAC AATTAATCTA ATAGATATCA TCTTGTGAAA TCCTCATITT ACCAATCTTA TTATGAGTC CTGGGTTG TGAGAACAAT GGGGTTCTGA GAGGCACCAG AGACCTCATG TTTTCCAAAA CCTAGAACAG TATAATGAAG GAAGGCGGGG AGGCAGGGAG GCAGGGAGGC AGGGAGGCAG GGAGGCGGGC AGGTGGGGAG GGAGGGACGG AAGGAGGGAG GGAGGGAGGG AGGGAGGGAG GGAGGGATAA AAAAAGAAGA ATGAGGTTGA AACCAGGACT TAGATATTAG AAACAAGCCA TTACAAAATT TATTTCTATG GTTAATrGTG GTTTTCAACT GTAAGTTACT TGGTGTTAAT TTCCTATTAA ACAATTTCAG TAAGTTGCAT CT1TI iATCC CATCTCAGGT CAAATACTTA ACAGACTAAA TGATTTGAAA AAGCAAAAGT TTACTGGCTT GTGTGTGTrA AAATGGAGGT ATGGTGGCTT TGATATTATC TTCTTGTGGT GGAGCTGAAT TCACAAGAGA TCGTrGCTGA GCTCCTACCA GACCCCACCT GGAGGCCCCA GTCACTCAGG AGAGATCAGG GTCTCACA ATCAGGTTCT ACAAAAATAA ACATCCCCCC AACCACAGCA GTGCCAGTTT CCATGTCAGA AACTTAGATC CAAATGACTG ACTCGCGTCT CATTATCATG ATGGAAAAGC CCAGGCTTGA GAAAGAAGCC CGCTGCGGAT TTACTCAAGG CGATACTGAC ACAGGGTITG TGTITTCCA ACATGAG'TT TGAGTTCT7A CACGCTGTTT GCTCUi1T-G TGTGTITII CCCTGTTAGG TGTTGGT GGTATAGGCG ATCCTGTTAC CTGCCTTAAG AGTGGAGCCA TATGTCATCC AGTCTTGC CCTAGAAGGT ATAAACAAAT TGGCACCTGT GGTCTCCCTG GAACAAAATG CTGCAAAAAG CCATGAGGAG GCCAAGAAGC TGCTGTGGCT GATGCGGATT CAGAAAGGGC TCCCTCATCA GAGACGTGCG ACATGTAAAC CAAATTAAAC TATGGTGTCC AAAGATACGC AATCTTTATC CTAGTAATTG TGGTCATTGG GTGATGTrGG TTTGGGCAGG CCATCTCTAA TATCCTTGAA ACACCYFITT CTGCTCTCCA GGAAGGGGTC AGGGCTGCCA CAGCGGGGCT TGGAGTGCTT TCCAGGGTCA CAGGCATCTG TATTCTTGG ATTCCTrGAC CTTCCCCATT TATTCCCGGC ATITTCCTAA AACGTGTGCT TTGCTCCTCC TGCATCCTCC CCTTGCATGC CCTCACCTAC CCCACATCTT CCCTAAAAAA AGCAAGCCCA ACTCAAAGAC CAGTTCCCTC ATGGAATCAT AGTGGATCTG CCAAGGGAGG GGATGCCCAG TCCTCTGTTC TTCACAAGAC TCCCTTCTTC TGGCTAAGGT TTCTTATGCA ATTAT CTGCAGTGGT AAAAAGATrC TATATCTGCT GITGATGAA TGCAGCACCC ACTAGCCACA TAGTGCTCGT GAGCACTTGC AATGCGGCTA GGGTGATTTC AATTAACCTA AAAGAGAACA GCCACAGGGA GCATGTGGCT GCCATATTGG ATGGTGCTGC TGAGAACA AAATGAGAGA AATGAAGCCT CTATTTACCT TGGTTGGCGG AACACATTGA AGGGACTCTG TATTGATACC AGGCTTCAAA CTTGGGAAG TGTACTGGCC AACTTAAACA CATCCACAGG AGAATGAAGA GGTTTGGGAA GGGACCAGAA ACCAGGCATT GAGGACAATG AGAAGAGTTT TTCAAAAGTG GAATrACTGC AAAAAGTGGA AAAATAGCCT TTGGATGGAA GTTACTGATG AGACAATTTC CATCGGTGTG AAAGCCATCT TTCCAACAGA GATCTGCAAC ATGAGAATGT ACTGTCTCCT AGGGTAGCGA TGGCCTCTTG TATrAGTCCG CTCAGGCTAC CAGATTrATC GTTTAAACTG CCCATAAACA GACCAGGCAG TAAACAAC AGAAATTTAT TrCCTCGCAG TCCTGGAGGC AGGAAGTCTG CGATCAAGGT GGAAGCAGGG TTGGCTTCTT CTCAGGTGTC TGTCCT7GGC TGGTAGATGA CCGCCGCCTC CCTGGGTCCT CACATGGTCT TTCCTCTGTG TGTGTCTGTC CCAATCTCT CTTATAAGGA TGCAAGTCTT ATGGATCAGA GCACACCCCA ATGACCGTGT TTAACTTGAA TCACCTTT AAAGITTCTC TCTCCAAATA CAATCACCTC CTGAGGCACT GTTAGGGCTT CGACACAGGA ATTUCTITCC TAGGGGATTC AGTTCAGTCC AAAACGCCTA CCAGTGGAGA CTrGCAACAT GGCGGCCTGC TGGTCCCTCG CCAGGAATAT CACAGGCGAC TGTTCCCTGT TGCATGGAAT AGAAGGCTAT TCCAGAGTAC TGTCTCTATT TATCAGATCT GGGATACTGG GAGAAGGGCA AAATAAAGTC CAAGTAGAAA AAAAAACTAT GAAAGTA GAGAGTAACC ATAATTTCAG CCCGATGTGA AACGATCCTA GATTTCAGCT GAAATAGTGA TGTGGGAAGT WO 00/09525 PCT/US99/1 7712 EPI-109 47 GAGGGGGCCG GGATTCAAGG CAGAGGGAAC AGCGTAACTG AAGGCATGGA AGGAGGGAAG TGTAGGCTGT G'T7GAAGAG TGGCAGCTGC FCCACA TT CTAAAACACA GGATGTGATT TTGGGGTGTG TTGAGACAAG GCAGAAAACT TGITITGGAAA AATAAC'FrGA A'TCCCTGCA CAn7TAAAAT CTCTCAGCAG AAGAAAACCC CACTCAGAAC CCCACTGT-rC ATTCCTTGGC TrGTA'IMGG SCACAGCTGG CATAGCCCCA GACTGAGTAA GCTCTTCAGA CACCTCATJT CATGAGTAGC CCCAAAGATC AATCATGGGC CAAIT7G GAAGAGAAGA CTCTCCGGTG 3TIGCAGTT A'ITrGTrCTG C17CGCGAG ATGTrCTCAA ATCGTrGCAG CTACAAGCCA TGAGTCTGAA GTGTIGTGT TCCCTCCTTA CAGGTGGTAA C1TCTCACA GGCCTTGGCC ACAGATCTGA TCATTACAAT TGCGTCAGCA GTGGAGGGCA ATGTCTCTAT TCTGCCTGCC CGATCI=AC CAAAAT7CAA GGCACCTGTF17 ACAGAGGGAA GGCCAAGTGC TGCAAGTGAG CTGAGAGTGA CCAGAAGAAA TGACGCAGAA GTGAAATGAA C'ITX=ATAA GCATCrrr AATAAAGGAA AATTGCT=F GAAGTATACC TCCT=GGGC CAAAATGAAT CTrGTGTCTC AATTrGGAAGA GGTAAAGAAG TAGGGGGrrA GGGTGCATGG GTTGGAACGT GAGACAGGTC GAACCACAAA GCCTGCCTGG AAAAGGGGAG TGACGTCCTA GGCrrCAGTG ATGTCACCTC CACMTGT-FT GATCCACAAA CCAACAGGTG ACTGA=1~G GTCAGCTCAG CCTCCAAAGG AGCCAGCCTC TCCCCAGTT1C CTGAAATCCT GAGTGTTGCC TGCCAGTCGC CATGAGAACT TCCTACC1TC TGCTG'I=AC TCTCTGCTTA CTITGTCTG AGATGGCCTC AGGTGGTAAC MI~CTCACAG GCCTrrGGCCA CAGATCTGAT CATrACAA'Fr GCGTCAGCAG TGGAGGGCAA TGTCTCTATT CTGCCTGCCC GATC1TACC AAAATTCAAG GCACCTG'FrA CAGAGGGAAG GCCAAGTGCT GCAAGTGAGC TGGGAGTGAC CAGAAGAAAT GACGCAGAAG TGAAATGAAC TT? GAAT7CACAT TICTCACCTI TFGATGTA'IT AAGAAAGTAT GGAGAAATAT ATCCTCTATC AAATIICAT GCCTrCAATA A2TMCTAA'T CATCAGTCAG TG1TTICCA TCCTITACTG TGATGATGCC C1TC11CCA AAC'FThCA TFIGCATCAGA GATGATGTIA CCAAT17CTI TGTCTCCATIT TGCAGAAAT? GTAGCAACCT GTGCAATrTC 'FICAGGTITG GTCACAGGTFI TAGACTGCTI? ITIAAG ITCA GCAATTACAG CATCAACAGC TAACATCACA CCTCTCIGA 'rIrCCACTGG ATIAGCACCT TI'GCTAACCT TCTGGAAGGC T7ATTrGGAA ATAGAGCATA CCAGTACAGC AGCAGTGATA GTGCCATCCC CCAGTCTCTC CAFFFGTGFT ATrrGGCAACA TCTIGGACAA G'FITAGCTCC AATGCT1TIA TATFIATCCT FIAAGTCAAT TGACTITGCA TCAGTCACAC CATCTITGT TACTIGGGA CTICCCCAGC TATGTTCAAT AATFIACTG'T CTTCC=IIG GCCCCATTGT AATGGCTACA GCATCGACAA AAAGTCTACA CTIGAAGCA TIAAGGCTCA GACATCAGCA CCAAA=1IA CATC'TIACC ATCACTFTCAA GTGAGGTGAG GAGCCAGTAG CCTGGACACT GGTCTCATCT GGTGAAAGAC TGTGGGTAAT GGAAGCMTT CTGTGGGGTG GTGGCAGGAC ATGTGCATGG TGAGGCAGGT CATCAGCAGC AAGTGAGAGC TGCCTCTIAC TFI7CTAAAGG TGACATAGCA AGTATACAAA AAAAAATAAA ATATTAAMI AGGCAGAGCA CATAAAGGCT YI7AMIICATA TrCCA'TrCT CTGTATG=I TCT-rCACCAG GAAGAAATAG TITIAGTGTC AGGAATGAAT GAGTCTGCCC CTCAATICCA GCCTGCTCAG CACACAAGGA AACAAAGCCC TGACAATCAG AGTGACTCCC TGGTGACTAA GCTrCCAGTCC TGGATGCATA 'TTGITIAGC AGTrCTGACA GCATCTGACC CAGCCCTCTC 'I1rGCATACC CCACCAGAAC CTICrflFI TTIMTTC TnTGAGACTG AGTCTwGCTC TGTCGGAAGC GA'TCCCGTG CCTCAGCCTC CCAAATACCT GGAATI'ATAG GCGTAAGCCA TCATGCCTGG CTAA'TTTG TAITXTICAT GGAGATGGGG TIIGCCATG 'I1GGTCAAAT TGGTCTCACA CTCCTGACCT CATGTGATCC ACCTGCCTCA GCCTCCCAAA GTGCTGGGAT GACAGGTGTA AGCCACCATG CTAGGCTCAG AAAMrCC~r 'ITATAAAAAT GTCA'FrAAGG ATCTI7GGCTG CACAATATCG 7TACCAGCYI? CC'TJAAATC CACCTCTGGC CTGCCAGGAA TCAGGGTIcT TCAGAACCTG ACATrAAA TGAAGAGGTC AGGCAGGTCA TGAGGAAAGC CTCA'I7GTCC CCATGTCTCT GTCACTGCTG CACCCCTGAG ACATCACAGA CATGGACACT GGGGCCTGCT TG'FrrCTCAA ACTGCCCTTrA GATCGAAAGA GGGAGGAACC AGGATGAATG CCACTCATTTr TCCCAAGAAA GGCCCTCTCC TGAGTGCCCG GGATGGGGCT CTGTCCAITG CCTGGGGCCG CCAATI7GCTA CTCTGGG'I1A CGGAAGAAGG ACAGGGTCCT GAGAGACACC AGAGACCTCA CACAGCCCTG AAAACATGGG GCTCCTFCAT AAGTG'TTrCC CATCACCAAC AGGGAGACCA CGTGGAGGCC TTGCAGCCCT ACTCGGTGCT TCTCCACCAA ATCCCAAGGG CAGTGACGCT GACGTCTGTG GAAAGCAGAG AAAGCCCTGG CTCCCAAAGC CCTGAAGTCC TGTGGAGCTG ACA FICCCTG AGTGACGGTG TGAATGGAAG GAACTCAAGT GCGGGTGGTA GGCCACCTCC TGGCCCAGGC CTGGGTGAAC TCTGAGGGGA CACATGTAGT CACAATCCCA TCCTCCCA'rT CTC=TCTCA GAGGAAGGAA GTGGGCATCC ATCTGCCTCA TCTCTCTCCC GTGGGGAAGA TGGGGAGFFI? CAGGGGAACT TI'CACATAAA ]TICACCAGC TCAGATCTCC TGTGAGGATG GGGCCCACCA TGCTCCCGGT GCTGCCAGAG GCCCTGAGCC CCTCCAGGGT CCCTGGGIMT GAGCCAGCCC TGTATCATCC CCAGGAGCTG AATGTCCGAA CAATGGATAG AATTAGATGG AAAGAGCTCT CAA'ITGGCC TGAGACTGTC CCCAGATACT CAGGAAAAAC AGGACGTCGC ACAGAGTGGG CAGCAGGTGA GTGGCAGGTT ATAGGTCCTG AGrrr7GAY~r TGTICTCACG TGAGACAGAC CCAGCCCCTC ACTCCATTCA CACACTGGGT TFIAAATGGT GCAAGATAGG AGGAA=1IC TGGTCCCAAG AGCAGGAGGA AGGGATITIC TGGGGnTICC TGAGTCCAGA TI'GCATAAG ATCTCCTGAG TGTGCATI7GT TCTIGAGGA CCA'FrCTCTG ACTCACCAGG TAAGTGGCTG AATI'CTAACC TCTGTAATGA GCA'ITGCACC CAATACCAGT TCTGAACTCT ACCTGGTGAC CAGGGACCAG GAC=i~ATA AGGTGGAAGG CTIGATGTCC TCCCCAGACT CAGCTCCTGG TGAAGCTCCC AGCCATCAGC CATGAGGGTC TTGTATCTCC TCI'CTCG IT CCTCTTCATA TICCTGATGC CTC= CCAGG TGAGATGGGC CAGGGAAATA GGAGGGTrGG CCAAATGGAA GAATGGCGTA GAAGTI'CTCT GTCTCCTCTC A FICCCCTCC ACCTATCTCT CCCTCATCCC TCTCTCTCCT TCCTCrCTCT GTGTGTCCCC TCCATC=II TCTCCTGC'FI' CTCTCTCTTC TICCCTCTCTr CTCMT1II CTGTC7 CT ITICCTCTC TCCCTAGAGC ATGTCWICT Tr=ITCTCT TFrCC1TCTr CTACCCACAC ?II1AGACTG AGTAGACTGA ATGCCCTATT TAATTGAACC AAGCATI'GCT TCCTICAATA GAAAAGGAGT TTGAGAACCC AATGGACAAC TCACCGFIC TI'CTAAGCCA ATATGAAGGA GCCCAGTAGT rrIGTAAATAT CATCCTICA CTGCITCCA TGCTACAACT GCTGAGACTA TGGTITGAAAC VIGTTAGGTG ACITITAAA TAAAAGGCAG AAA1T=GAT ITIATCTAAA GAAAGTAGTA TAGAATGTCA TTPCTAAAT =IrATA'FTr AAAGAGTAGA TACTGCAACC TAGAGAATIC CAGATAATCT TAAGGCCCAG CCTATACTGT GAGAACTACT GCAGCAGACA CTCTGCCCCC AGGACTITC TGATCAGAGG CCCTGAGAAC AGTCCCTGCC ACTAGGCCAC TGCAGGTTCA CAGGACAGGG ACAGCCCA'IT GAAACCAACT ?TTrAAACCTG GATGCCTAAC =~CA=TC. TCCTI'GATAT TATGAAAATA AAATAAAAAC CATGAAAGGA TAAAAGAGGG AGAGTGGAAG GGAAGGATGG AGAAAGGGAA AAAGAAAATT TGAGAGTAAA TCCTAAAACA ATTIAATCTAA TAGATATCAT CTTGTGAAAT CCTCATIIA CCAATCTIAT 7TATGAGTCC TGGG=TGT GAGAACAATG GGGTCTGAG AGGCACCAGA GACCTCATAT T"ITCCAAAAC CTAGAACAGT ATAATGAAGG AAGGAGGGAA GGAGGGAGGG AGGGAGGGAA GGAGGGAAGG AGGGAGGGAG GGAGGGAAAC AAAAAGAAGA ATGAGGTIGA AACCAGGACT TAGATATITAG AAACAAGCCA TIACAAAATT TAT17CTATG G TAATFIGTG GTITCAACT GTAAGTrACT TGGTGTTIAAT TICCTATTAA ACAA'TT7CAG TAAG'ITGCAT CTITITIATC CCATCTCAGA TCAAATACTI? AACAGACTAA ATGNITTTGAA AAAGCAAAAG 1TIACTGGCT TGTGTGTGFI AAAATGGAGG TATGGTGGCT TFIGATAT-rAT CT1GTGG TGGAGCTGAA TTCACAAGAG ATCGTrGCTG AGCTCCTGCC AGACCCCACC TGGAGGCCCC AGTCACTCAG GAGAGATCAG GGTCITCAC AATCAGGTTC TACAAAAATA AACATCCCCC AAACCACAGC AGTGCCAGTI' TCCATGTCAG AAACTTAGAT CCAAATGACT GACTCGCGTC TCA7TATCAT GATGGAAAAG CCCAGGC'rG WO 00/09525 PCTIUS99/1 7712 EPI-109 48 AGAAAGAAGC CCGCTGCGGA =~ACTCAAG GCGATACTGA CACAGGG'IT GTG I1TCC AACATGAG'T TGAGT1TC'fl ACACGCTGTT TGCTC'TIT GTGTG'ITIT TCCCTGTTAG GTGTTGG TGGTATAGGC GATCCTGTTA CCTGCCTrAA GAGTGGAGCC ATATGTCATC CAGTCTIG CCCTAGAAGG TATAAACAAA TITGGCACCTG TGGTCTCCCT GGAACAAAAT GCTGCAAAAA GCCATGAGGA GGCCAAGAAG CTGCTGTGGC TGATGCGGAT TCAGAAAGGG CTCCCTCATC AGAGACGTGC GACATGTAAA CCAAATTAAA CTATGGTGTC CAAAGATACG CAATCTIAT CCTAGTAAT~r GTGGTCATTG GGTGATG TrG G=~GGGCAG GCCATCTCTA ATATCCflGA AACACCTIT TCTGCTCTCC AGGAAGGGGT CAGGGCTGCC ACAGCGGGGC T'rGGAGTGC GAATTCCCTG TAAGCCCTGT TACAGGGGCT GCACCCCAGA TACAACCTGA CCTGTGTCCA AGGCGGGCAA CTCAACCCTT AGATATTGAA TGGGTCCCAT GGCACCAATG CTTAAACACC AGCAGCCCTC ACAACCACAG ATCGTG I I AAGGATGAGG AGGTAGITrC CTGGATGCAC AGGCTCAAT CCAAATGGGC TCATGACGCC GCAGCACACA CCCAGTCTGC AGCCTGAAGA GTTGGAGCAT TGCATTCACA GAAAGCATCC AGACATGATC ATGGGCTCAG GGATACACCT GTrCTCCGAT GTGTACCAGT GAAGGATGGA AACTCCTATG CCTCCCAGAA AGCACCACTC AAGC'IfGC TGAATGCTrC TCTGAAGGCC CACAAGGCTG AGAGGCTGTG CAACACCAGC AGTAAAGTGA ATGCCCAGAC TCCCACCTCC ==CFGGGT GGCCATCTGG AAAGGCCACT CCCACCCTGA TGGCTAATGC CTCAGACCAG ~TT=GGCCC AGATGATCCT AGACAATTGT 'FAAGCTrAA ACTGTI7CATTr GGCCAAGCAA ACAGGTGATA GTACCTCTGG GGAACCACAT GCCGCGTGTA CATCCAGATC TCAGGAGAAC CCAAAAATGT CTGT7CCACA TAGCAACAGA AGCCCAGGTA GCACTCAGTC TCACCTGGGT GTI7C1TCCAAC ATCCCAGCTC AGCCAAATGG CTICATTAG TTTTATGGT TAGACCCCAG GTCCTCGGGA CACTGCT=A GAAACACATT CCAAATCCTC CTCTGTGTGC AGGTGGCATr CCTATCCCAA TCTCTTGCA GGGCGTATAC TGTGATACGC AGCCAGGCTG TCCCAGAGGC CTAAATATF CCC'ITGGTGC AGGTAGTrCA GCTTAGCCAC AGCCAATGCA TCACAGGGTC AACTGTG'rrA GGAGCCA77G AGAATCCATA GTTGG'FrGCT GCCTGGGCCT GGCCAGGGCT GACCAAGGTA GATGAGAGGT TCCTCTGTGG AGTTCTACTr TAACCTCACC 'FrCCCACCAA ATFITCTCAAC TGTCCTrGCC ACCACAATTA TITAATGGAC CCAACAGAAA GTAACCCCGG AAATT1AGGAC ACCTCATCCC AAAAGACC117 TAAATAGGGG AAGTCCAC1T GTGCACGGCT G~rCCTTGCT ATAGAAGACC TGGGACAGAG GACTGCTGTC TGCCCTCTCT GGTCACCCTG CCTAGCTAGA GGATCTGTAA GTACTACAAA ACTrAAACT TACACTGAGT =~CATCAT7 GAAGCTATGC CTCCAATCTG ACCTCTGACT GTGGGGCCGC CCCAGAGGGA CCCAGCGGGT GAATCCCTGC TAGGAACGTC TGTCCGGACC TCTGGTGACT GCTGGGGACG ATGGCTICCA GCTAACTTAA TAGAGAAACT CAAGCAG=r C=~CTAAAT ACACATGTCA CATGTCCTGG TTGACATGTC CAGTAAGAAG ACTATCACAG GTCI=GGAA CA'FFCTIG AGAGAAACCT A'I=AGGTCC 'FrGGTCTGTT MFCAATCAG G17GTF7GAT TI=GCTA'Fr GAGTTGTTrGG AATrCCTrAT GTATTCAGAT A=TGCCCCT TCTGCCATGT AGGTTTGCA AATA=IICT CTCA=ICT GGG7FATCTT T'TCACTCGGT TGATTGM~C C1TGCTGTG CAGATGC'T AGCGTI7AAAT GAAGCCACAC T7GTCTAMT TCCCrI=AT TGCCTGTGCC 'I=GGTGTCA TAGCCAAGAA ATCATTACCT ACATCAATGT CAAAAGC1T ATCCTCTAT ACACT-rCTAG TAG1TT7ATGG TITCAGT7GT TACA'TrAGG TITCAATTC ATTCTGAG F7 GATGrrCCTA CATGGTGTGA GATAAAGA77 TAAATACATA CATATATAAA ATCATGAGGT AGTGTACACT ATAAATATAC AA'FrGTrAAT TG17ACTCAA GTCTAAGTAG AGGTGGAAAT AATAAACTI7 C7T=lrA CT1TAAACCAC TCTGTGTCAC TGAGCTGATr TCACC1TAG CCTGATAAAA TCATTGTCCT CTCCACCCTG ATTCCTACAG GAGACTACTC ACCCCATAAC CTCAAAAACC TCTTCATGAG GATGGTAAGT CACCTGAATC CTGAAGTGAA FrACTCGCTA T7CCA'T7GGA ACTCATATAG GACACCAGAA TCTAGACCTC CAGAGAACAG CAGGACCCAT C=CAGAAAA TAAGAAGCAT TrGTTCCCTG AGCCTGTI'GA ATCAAAGTGC AA TTCTAT-r C'TTrGGAA TGTrAAAAAG TGAATCATAA TA=TAAGCA GGTGAACCCA CGAGTAACAT AGCAGGGTCT TTCTrGTCAT TAT7AGCTCC AACCTAGCAC AGACATrAAA GGTACAGATG TATACTAGCA TGAAACTGGG AGAACAGGAG CATTCGAGCA ACCIGAGAC CAATGGGCCT CTCTrATAAA ATGCACACCT CCTCTCACTG AGATTGAGGA AGGM1CTTG TCTCCGAGCC TrCTCCCAGT AGAGCTATAA ATCCAGGCTG GCTCCTCCCT CCCCACACAG CTGCTCCTGC TCTCCCTCCT CCAGGTGACC CCAGCCATGA GGACCCTCGC CATCCTrGCT GCCATrCTCC TGGTGGCCCT GCAGGCCCAG GCTGAGCCAC TCCAGGCAAG AGCTGATGAG GTI7GCTGCAG CCCCGGAGCA GATrGCAGCG GACATCCCAG AAGTGGTTGT T7CC=FGCA TGGGACGAAA GCTITGGCTCC AAAGCATCCA GGTGAGAGAG GCAGGCATGC AGAGCTGCTA AGTCTAGAGG GAAGGACGGG AGAGAGGITC CAGAGI7GGG TCTCAGCAGT CTATGTCACT GAGGTGGCTT CACTAGAAT CTCTGGGCAT TGA=IICTC ATCTAGAAAT TGAACAGAGA GCCAAATAAA CCTGAGAAAC 'FrTA'TrCTC CAAAGA=~G ATT1CCAAGAA ACATC7GTGA AA17CACTAA G'IMAAGATA TGAAGAGACA GACTAGTTAT T7CTGGATCT AAACAAGTAG AC'TAGTrGT AAAGAGAACA TITACTCTA TCTACAGAAG AGC'IIAAA AACTGCAGCC AAGCCTGAGG GTAAGTTCAG GTGTGTGTGT GATGGGGCAG GAATGCAAAA ATGAGAGCAA AGGAGAATGA GTCTCAAATTF CTGTGTGACA AGCACTGCTC TGCGTG 1TA 'F[CCTATCGA CTGAGGT7GT TCGTG3CTACC GGCTGCAATG CAGCCAGCAT CACCTGTCAG CTAGCATGTG AC=CCCCGA GATI7=lT CACCCACT GCTAACTCCA TACTCAATI CTCATGCTCT CCCTGTCCCA GGCTCAAGGA AAAACATGGA CTG~ATF1GC AGAATACCAG CGTGCAflGC AGGAGAACGT CGCTATGGAA CCTGCATCTA CCAGGGAAGA CTCrGGGCAT TCTGCTGCTG AGCT7GCAGA AAAAGAAAAA TGAGCTCAAA ATIT7GCTG AGAGCTACAG GGAATrGCTA TTACTCCTGT ACCTh7CTGCT CAA=ICMT TCCTCATCTC AAATAAATGC CTrGTrACAA GA TCTGTG 'I77CCACCTC ITAATGTGT GATATGTGTC TGTGTCAAGA CACTrGGGAT ACACGTACCA AAACGCAAAA TCAAATIT GAACAATATA CCTACCT7GC TATAGAAGAC CTGGGACAGA GGACTGCTGT CTGCCCTCTC TGGTCACCCT GCCTAGCTAG AGGATCTGTG ACCCCAGCCA TGAGGACCCT CGCCATCCTT GCTGCCArrC TCCTGGTGGC CCTGCAGGCC CAGGCTGAGC CACTCCAGGC AAGAGCTGAT GAGGTTGCTG CAGCCCCGGA GCAGATTGCA GCGGACATCC CAGAAGTGGT TGTI'CCCY[ GCATGGGACG AAAGCTTGGC TCCAAAGCAT CCAGGCTCAA GGAAAAACAT GGACTGCTAT TGCAGAATAC CAGCGTGCAT TGCAGGAGAA CGTCGCTATG GAACCTGCAT CTACCAGGGA AGACTCTGGG CATTrCTGCTG CTGAGCTGC AGAAAAAGAA AAATGAGCTC AAAATrTGCT ITGAGAGCTA CAGGGAA F7G CTATlACTCC TGTACCTCT GCTCAA'ITC =T~ GATCAAAA77TT-fIACC7TT ATGCA'ITTGA TATATAAATA AGTATATAAA TGCACACACA GACACAGCAA TGATGGTGAA CAGTCT7CAT ACAATI'ATAT GGATGAATCT CATAAAATGC TGAGTTAAAG AAATCAGACC AAAGAACATA TACTGAAAGA 'ITCTCTCTAT ATACAAAG317 CAAAAATAGG TGGACCAATT CATGGTGGTG TTAGAAATCA GAAGAGAGGC TACC1TGTG GGGAGGGGAC AGT17AATGC CCAGAAGCGG TAAATAAGGA ATCCTCTGGG GAGTGGTAAT GATCTGGATG CTGGCTACAG GATGTGTTGG T7GTAAAAAT GCATTEIT ATATCTAGCT TITCCATGT GTATATI7ATA CrTCAAAGAA G F7CAGTTAA TAAT7CTCA TGTCACTGTA GAGTAGCTCA GTTAGCCCCA GCAAGCCTCT GGCT'TAATCT TG'IflACCT TAAGCCATCA GTCATITACA AGTAGGAAAA TCACAGGGA AAGTrAGAGT ATAAAATCCA GAATGAAGGT rACTGGGTA AGAGTCTCTC CATITCCAA AGCCCGT17A =IICTGATFF CCAGTTCTTA AGAAGTCTCA GCATTGTGTC TITICATGT AT=TACAAG AAGACAGCAT GTGCT7CTAA CACCTGATAC ATTGTATCTA CCAGCAC=G GTAAACAGAA AAGAACCACA TFTW11GT AGGAGAAAT7 TGGTGCCTAT 'rCCTACCAG GCACCAATAA GTGGGACCAA TAGGTGGGAT TAAAGATACA GTAGAAAGTA =I~AAAACT-r GCCAGGGGGC AATAGTCTGA AAATAAGTAA ATTGGTGCTA WO 00/09525 PCT/US99/17712 EPI-109 49 TAGAATGGAA GTTACAGGCT TCTTTCTIT TTCCCACAAG ATCTGCTCCT TGAGCCCCTA GAGACTTTTC TGTCTGTrAC TGTITCTTCA TTCCTCATCT GCAGAGCCAG CCCTGAGAAG TGCAGACCAA AGCCAGGGAA GGCTCTGCAA AGATGTACAA ATGGAAGTCA CCTTAATAAC CTCTGACTGC TGCGCATAAT ACATTrCACT CAAAAGAGGG GTTAAACAAT GGAACAGAAT ACAGAGGCCA GAAATAATGC TGAACACTGA CAACCATCTG ATC=TGACA AAATCCACAA AAACAAGCAA TGGAGAAAGG ACTCCCTATT CCATAATGGT GCTGGGATAA CTGTCTAGCT ATATACAGAA GATTGAACCT GGGCCCCTTC CTTACATCAT ATACAAAAAA TAACTCAAGA TGGAGTAAAG ACTTAAATCT AAAACCAAAC ACTATAAAAA CCCTGGAAGA TAGCCTGGGA AATACCATTC TGGACATAGG ACCTGGCAAA GACTTCATGA CAAGACACCA AAAGCAATAG CAACAAAAAC CAAATTGACT AATGAAACTA ATGAAACTCT TFAGTTGTAC AACAGATAGT TTATCTGTAC AACAAAATAA ACTATCAACA GAGTAAACAA CCTACAGAAT GGAAAAATTT TTTGCAAACT ATGCATCTGA CAAAGGTCTA ATATCCAGAA TCTATAAGGA ATTTAAACAA ATTTACAAGC AAAAAAATGA CCTCATTAAA AAGTGGGCAA AGGACATGAA CAGATGCMTT TCAAAATAAG ACATTCACAC ATCCAACAAC CATATGAAAA GATGTTTAAC ATCACTAATC ATTAGAGGAA TACAAATCAA AAGCATAATA AGATACCATC TAATACCAGT AGGAATGACT ACTATTAAAA AGTCAGACAA TAACAGATGC TGGTGAAGGT TGTGGAGAAA AGGGAATGTT TATGCACTGC TAGTGGGAAT GTAAACTAGT TCAGCCATTG TGGAAGAGAG TGTGGTGAT7 CCTCAAAGAA TGTAAAACCG AACTGCCT CAATCCAGCA ATCCCATTAT TGGATATACA CCAAAAGGAA TAGAAATTGT TTI7ACCGTAA AGGCGCATGC ATGCATATGT TCATTACAGC ACTATTTACG ATAGCAAAGA CATGGAATCG TCTAAATGCC CATCAGTGGT AGACTAGCTA AAAAAAAAAA AATGTGGTAC ATATACATCA CAGAATAGTA TGCAGCCATA AAAATGAACA AGATCATCAT GTCCTTTGCA GCAACATGGA TGTAGTTGGA GGCCATTATC CTAAGCAAAT TAATGCAGGA ACAGAAAGCC AAATACCACA TGTTCTCATT TATAAGTGAC AGCTAAATAT TGAGTACACA TGGACACAAA GAAGGGAACA ATAGACATGG GACCTACTTG AGAATAGAGG GTGGGAGGAG GGTGAGGATC AAAAAGTACC CATAGGACAC TGTGCTTATT ACCTGGGTGA TGAAATAATT TGCACACCAA ACCCCTGTGA CACACAATTT ACCTATATAG AAAACCTGTG CATGTACCCC TGAACCTAAA AGTTAATGGT GGGGGGGTGG GGTTAAGCTA CTTTGTGGTA TAAATCTGAG CATTCATATT AAAATAAAAT ATTACCTCA TTAGAGTAAT TAACATTAT TAAGCAAAGA GCCAAGTACC TTACACACAT GATGTTAAT CTCACAATGA TCTTTAATCT CATAACAACC GTCCATTGTA TGTACATATG TGGAAATTGA GCCTTGGAGA GATTAAATGC ATGGGGCATG CCAITGACT AGAAACTGGA AGCATCAGGA TTTAAACTCA GTTCTGAATG GTTTTGTAGG CTGTTT TCCACATTAT AGCATGGCCT GCCATGAAGA ACAGGTCCTT TCTGGTGTTT GTCTTGTTTG GTTTAAGTGA AGCAAATATT TATTTAAATA TTCAAGATAT GCTGTTAAAT TTACTCAA AAATTTGAGT ACAGTATGGA TCTTCTGAAG CCAAATAACT CTrATTCAAT GCTTAGTTGA GAAATTTAT GGAGTAGTTC TCAATTTA TGTAGTTCCA CTGCAAAGGT AAGTCTTATG GAAAGATTCA CTGTAATT TITrCCTCAT T7GGACATCA GCTTTTTCTT TTCCTCAGAC CCGCTGAAAG ATAATTA AAATAAAAAC CTTGlITITA TATCAAGTGG GGACAITlIl TCCAAATGAA AACCGTGTAT TCATTTTATA TGATAAAATC AATGTTATTA ITITIAAAAT TTTGATAA AAATCATTAA AAATAAATTr TCAGATATTA CCTGAAATTC TACCATCCAG AGATAATAGT GCTTAAAGAT TTGATATATA GACACACACA CATATATACA TATATATCAT CCTAAACTTC TTTGTATAAA TGTATATAAA GTTTAATA AAAACTAGGA GATTAATGCC C=TTGAATGA AAATAAATAC AATGTGTATG CTTAACATC TTGCCTAC TTATAACAT TTATCACAGC AGTCATGAGA TAATGATA CATGGTCATT GTfAGTAAGC TAATAGCTAA GTGCATGAAC TCTGGAGCTA GCCTCCCTGG ATTAATCC CAGATCTGTC ACTGACCAGC TGAGCAATAC TAGGTAAATT GCTCTTGTTC CTTAGTTTCT TCATCTGTAA AATAGAGATA AAAATAATAT CCACCTCATA GGATTGGTGT GAGCATTAAA TGAGCATACG TATGTAGGCC ACTTAACAAC AATGCCTTCA CATACTGAAC ACAAATATAC GAGCTGTFGT CTTATTGGGC TCATGTITIT CCTACCACTA AGCCGCATGC ATGCAAGGAC CATGTTGGTr TTGTrCCACA TTGCATCCCC AACCTGGTAT ACAGTGTGCA TTCAATAGTT GTrGACTATT ATTACTAGTG GCATTAACA AATATCTGTT AAATGAGTGA AGAAATACCC ATACTGCA AGTGTGTCTA ATATTGATGG CATAATGGGG GAAACTCAAA CTCTGGAGTC AAACAGGT TAAAACCTrA TTCCCTCATC CTCAGTTATT GACGiTl1T1 TTTTGGCAGG TGTGTGTGTG GGACAACTTA TTGAACT1i CTGAATTTCC AGCTTCGCAT ATATAAAATA GAGATAGTGA TTCATTCTrG CAATGTATGG ATTGAGACA ATTGTGTAAG TTTATCAATA AATAGTAGCT ATTTGTAT AAGTATTACA TATAATATCC AGGCCACTGC TTTGCATAAC CCAAAAGGGG CACCATTCAT GCAGAATACA ACATAAATGG TGTCCCTGGA GCAGTGCAGT ATAGGAACCC TGAGGGGACC TACAGTATAC T=TATAGTTC ATAGATTACA AATTATCCCT TTATCAGAGT CTCTCAAGGT TGGATGTATT TGAGGTCCAT AAGAGCAATT TAGGATTAAC AGTAGCTGCA GAAACCATCT GCAGTGATAT TCTCATITA AATCCGCGGG AAAGAAGACA GCTATAAACT TGGGACCTGG GTTTAAGCAT TTAAATGCC AAGTTCACCA TTTTCTAAAA CACAACAAAT ACCCAGTGAG AGAGGGAGAA GGGAAGTAAA TGCCTCTGAA TAAGCAAGTT AATGTCAGTA GTTGTACTGT ATGCATATTG ATGAACAATA GAGGAACCAA TGTCCAATCA GATGAGCAGG ATATTTGGCA ATAACAAGTT GCCTTGAGG AAAAATGATT TTCTTGGCAA GTTCTTTATC AGCATTACAA AGCTAAAAGC TACGCTTATC ATCACTTATA CTAGCATACC CTGTTGTGCA AATGCTGTCT GTGTTGCAT CTGCTATTGT TGATGCCTGG TGCATGAATC AGGACTCCAG CCCACAAGTT TTCCCAGAAC TTCTTATGG CCATCATCTT TAAGTGTCTG GTGAACAGTC ATAGTTTGGT ACACAAAAGG GTCAACCTGG GGGATGGCTA GGGTTTGACT CAGTCGTTAC ATTrCAATAG AGCAGGAAGG GGAAATGGTG GCCTGTAACC TCAGGGAATT TTGCCAGTTG GTCCACCCCA CTCTCTCTCT CCTGCTCTGA GGAAGTGGCA CAGCCTAGAA CAGCACCACA GGTGAGAGAA ATGCAAACCC TAACCAGAGA AGCAGACTCT TTGCCAGTAG TAATAGTTCA GGACCACCAC CAGCTTAT TAAAATITr AATAACACTC AAGTATrGGC AGAAAGAAAT AATCTTGGGT TAACTATAAC TAGAATATTG ACTCTTCCTC TGTGGAAGAA TCAGCCAATC ACATTGTIT ACATCAGTTC CCCTGAAGAA GAAAAATACA CTGATGTTGC AGCAAGACAA ATTTAAGCTA GATGTAAATA ACTTCCTTTA GCCTGTAATG CTAGGCTAAT TACATATTGG AACTAITr TCAGGGAAGA ATTGTGTAGG GTTTCAGGGA AGAATTCTGA AGAAAATATA GAGCTGAAAT GATCTTGCAG CTCACTGAAA CTGCAGGGTT TAGATCCACA CTGATACTCG TTCTATTATC ACTGTAATGA AGGCTGATGG AATAAGTAAA AATGTTTGT ATTAGTATGT TTACACTT ATTrGCAAGG CATAAATAGG TTAGGTTTG ATCTTAATTT AATTCTAACA TGTATrGTGC ACAAGCTGTG AGCAGTTTTC AGGAGTTAGG TATCTGGCCA TGACTGATTT TTCAGGAGTT AATCATCTGG TAGAAGGGTC ATACACAATA GGAAGATGTG TGTGACAGGT TGTGATCATT ACTATAATCA CACAGAGAGC TGTAGAATTT TAGGCTGGCA GGGTGGCTCA CGCCTGTAAT CCCAGCACTT TGGGAGGCCA AGGCAGGCGG ATCAAGAGGT CAGGAGATGG AGACCATCCT GGCTAACACG GTGAAACCCC GTCTGTACTA AAAATACAAA AAAAAAAAAA AGCCAGGCGT GGTGGTGGGC GCCTGTAGTC CCAGCTACTT GGGAGGCTGA GGCAGGAGAA TGGCGTGAAC CCGGGAGGTG GAGCTTGCAG TGAGCCGAGA TCGCATCACT GCAATCCAAC CTGGGCGACA GAGGGAGACT CAGTCTCAAA AAAAAAAAAA AAAAAAAGTC ATGTTAGATC CAGAGGGGTA GCAACTGGGG CTGGGCTGTC AGTCAACTCA GTCAACTCAG TCAACTCTGC TCCCCCACAG GAGATGCCAG TGATGCATTT TCATGGCCAA CATTGTCAGT CAGCATCATT GAATTACTCC TGATATAGA GACACAGCTG CAAACGATTC CCCATTAAAT ATGATGT7C TTGCAATGTT TGGAAGGTAC TCCTfTTAG TAAGGGAAAT CCCCTCTTCT GGCTTGCTGA AAGITiTC TTCCATTTT AAAAATCGTG AATTCCT TGCAATATTG AGGTGGTTAT ATGGTTCTC TTCTCTAATC TGTTAATATG GTGATTTAAT GGTTAGAAAT WO 00/09525 PCTIUS99/17712 EPI-109 50 TTTCTAATGT AAATTCCACT CATATTGCAG AAATAAACCT AAACTGAGCA TGAGGCTATA 1TITITT GCTTCTATAT TTGGTTGCTA TACAGTATTA TGTTTAAGAT TTGTTCACAT ATA717GTGA ATGGGATTGG ACTATITIC CTTCTTGCCG ATTTATCT GGITITrAAA TTAAGGATAT TTTAGACTTA TGAAATATT GGCAAACAAT CCTITGGCAAG TAATIT111G GGGAAT'ITGT TTGGCTATT TTGAGTATTA CCCAATATAT TMTAATTAAG TTATrCTrAA TGTTCTTA ATTAAAAAAA TTACCTACTC TAGAGATATT CTTTATGTAC TCCAGATTTT GTCTATTTAT ACCALTTC 'ITITICCTC GATGAGTGTC ATAGATGTTC ATCTATITI TrATCTTCTT TGATCTTCTC TTATTCCTTG TTT'CTATTAA CTTCTGAAGT TTATTATT CIT111ICCA CTTCCTTATG GTMTATTCTT TCAATTITC TCTAACTTCT TAAGTTGGGT GTTTAA'TT TAGCTTGCTT TGCUITirTA GGATAAGCAT TAAAACTACA AATTTTCCTT GTTATrCTTT TGCTGCACCC CAAATTGTTG ATATITCTAT TGTCTAATTT CTATTCAATT AGAATACTTT AAAGTTTCTT TTTGGFTITT AAAAACTAAC TTITAAATT GACAAATAAA AATTGTGTAT ATTTAT7GTG CACAGCATAT GGCTGAAA TATATGTACA TrGTGGAATG GCTAAATA GCTTATTAAT GTATGCATTA TCTCACATAC TFATCATTTT TTGTGGTGAG AGCTATGTGA CT1TTGAACT TATGAGTTAT TTAAATATTT TTAAATTATT AAGCATATrG GGATITTAAG TAATTTACCT TTATTATT AACTTATAAC AAGTAGAACA GTTAACCTGT ATGATTCTAC ATCATTGAAA TTTATTGACA TTGCTrCAT AGTCTATTAT ATGGTCTACT TTTGTTCATG TFrACATCTGT AGTAGAATTG GCTAATAGTT GAGTAAAGTA CACATATGTC TATGAAATCA AGTGTAATCC AGAGAAAAAG AGAAATTTAC TGAATATATT GTTCTAGGTG CTATTATATG TTGTCATGTT TAATCCTCAC CACAATTGTA TGAGGCAGCC ATAATTAATT CCACITTACA CATGAGGAGC CTGAGGGTTA AAAAAAAAGC TAGCTCTACT ATTTGTAAAG AATGAAGCAA AGATACAAAT GAAGGCCCAC ATATCCTATA ACTAGATATT TAAGCATT AATTCAAGCT TTAAAACTGC TAAATAAAAT GTGCTCCAAT TTCTATATTG ACAGACATAC CTTCCTAATG AGCTGGGGTT CGAATTTAGA AATCTTGAT GCTTCAGAGT CCACACTGAA ATGTGGAGGC ACATAGTGAG TTGGTCCCCA GCCTTCAGTC CACCCACCTT CTCTTTACTA AATCACCTTT CACATACATG TATGAACACC CCAGCCTCCA AGTCCAAACC CTAAACAAAA TGGGACACCC TTGTGCATAC ACAGAGACAC AGCCCATCCT CAGGAAAACC TGGAAAAGTC CATACAAGTr CTGGAAGCAA GCTTGGGACG GTTTCAGTAG TGTGGTCTAT AAGGGAGGCC TCAGAAGACA GGTTTCTTA ATTCTGTGAA CTTCTCCCAC AGTAGAAAGG GTGCTGGAGG AGGGTCAGAG TGAGGACTTC TAAAGCATGG GTCCTGAGTA GGGGCCACTC TTGCCCAAGT CTAAGAAGGG TACTAGAATA GCACACTACT ACTAGATACT AGAACCCAGA TACAAGCACA GGTCTTCTGA AATTAATAAT AATAATAACT ATTACCATTA TrATACCAGT AGCTGTCATT TATTTAGTGC TTATrATTTrG CCAGTCACTG TTCTAAATTC TTTACATGTA TTATACAACT GCCATATAAC TGCCATATGA GGGATGTACC CTCATTGTCA CCATTTACC GATGAGAAAA CTGGCATAAA ACGTTTAAGT AACTTGTCCA AGT7ACAGAG CTAGTGAAG CCACAATGTT GCTCAAT-FG CTCTCAAACT TCAAAGGGAT GGGAAGGACA CCTAAGTCAT AGAGTCTA AGAATCAGAG CTAGAAGGAA TCTTAGATGT TATCTAGTCA GCCTCCTCCC ATTACAGTCC AAGAGAAGAT GGCCCTGAGT TACTTGTAGC TATITTGCA TGTGAATTGC AAGTGAATAT ACATTCTACT GAAGATAAAA GATATTTAAA GATATCGCTG GATATAGGAA CAGTGGTITT AAATCTCTAG GCTTAACTT TTCTCAGAAC AAGAAATCCT TTGGTT AATCTATATG CACATCTGTA TITCTCAA TTATCGGGTA GTAAAATATA ACTTCTTC TGTAATATTT TAACTA ATGAGTGTrC CTCATAATAG AAAAGTTGG AAACCATTGC TATGGGTATA TACTTTCTAA AGGGATAGTA AITrCTCTAG AATATrCATT TAATGCTCCA GAAGTAATTA GCACAATrGT GCAAGTCTGT GCATCATCAA CTATACATTC TGCCTGTA CTCCAAATCC ACATGAAACT GATTATACAG TCAAAGGCGA GCCCAGTGGA GAGGCATTTT TGGAGACTTC CTGGTACATT GAGACAGGGT CGGCCAGTCT GCGTTAGGGT CTTGGTCAAA ACTGCATC TGAAACTAAA CTCAGATTGC TCTrT AA GGGGTCAGAA CTGATTCAAA TCTACATTTT TAAAAGCCTT AGATGTGGGG Ci1T1CCTAT TCCCAGTCTC CGCTATTGGT CTTTGTGAAT CCACAGGCAA TGGCCACA TCCTTGACTC TCTCTTATAT TAAGAATTAA ACAGCTAAGT TCATGCAGAG GAAATATAAC AAAGGAGGGA CTTTCCTACA AGATCTTTGA AAAATGGAAC ATTGCATAA GTCATATA GCCAGAACTG TTGTITATA TTTCCTTC TGAATACT GTTACACCTC CTCCCAGCCA ACCCCCCCCC TCCCTGACCC CAACTAGTCA GAGACCAAAG CCTTCACAAT GGTTTACACT TGAACCTTCC TGGCCCCACC CTCATCATCA CGCCTGAATA ATTACATT'CA CTGACTGGTC TCCCCTGCTT CCGTTTATCT CCACTCCTAA ACCCTCTGAC ACCTTAATCT TCCCAGAATA CCATTGTGAT CCTGTTCCAC TCTTGCTCAA GTTCCCAG AAACTAGAGT ACAAACTA TAAGCTTTAG AGTTGAAAGC CACTCTATCT CTTTCATC CCCAGGTCTC TGCCAAGGCA GTATAACCTG TCCAACATCT CTAACTTCAA TACCTTTGTC TTAGATACTA GACTCTCCTC CTGGTTTCTA ATTAAACCTG ATCTAGGATC TAATTGCC TCTGAAT7CT GTTGCCCTT GCCAAGTGAT CTCTTCCTCC TCTGAGCCGC AGCATCTCTG AGCTTGCACA CTTAGCATAG CCATAGCACA CACAGCCTTA GCTTGCAGTT CAGGGTGTTT ACCT7CCCTC CCCTTCCAGA TGCTGGATCC CCAGGGATAG GAACTCTGCC CTTATGTGTC CATAGCCCCT GGTAGTATGT CTTGCAGTCG TACAT=TCA GCAAATGTTr AATTGGTTAA TTGAAGACAA CTGTCCCATG CCTTAAGCCT CTCIT1TGC TAAACATGCC TGTGTCCT GTCATTGAAC AACTATITTG ATCTATITC TTCCTGACAT AGGGGTCAGT TCCGAGGATG CTGAAATCAA GAGACATAGC TTATTCTCTC AAAATTGCTT TCAAGAGTGA TTTGTrGTG AATTGAGAAC TGGCTGCCTA CTITTGGACT ACCCACTTCA GCAAGAGTGT TTGAAACCAA ATCTATTCTA AGTAATTTT TATTCCCTTT TCTCTATGGC ATTAGACACA CAGCTCTITT AAACTACCTr TCGTTATCTA TTAAACAGAC ATTCAGTAAC TCTATAGACA CTGTCTAGCT ATATGAACTT AGACAAACTA ATATCTCTGA GCTTCAGIT CTTAAAATIT AAAATGAGGA CAATACCATC TATGGCCGGG GATrAAATGC TATGAGGAAT GTAAACCAGA TGTCAGGTAC CATCTCTCTA AAATCCAGAT AAAATGAATT AAAAATACTG GCCGCAAACC CTCTCTAAGA GTTCTCAAAA TTCTCAGAGA GCTTAAT=T CATGCTCACC ATAGCACCGA TTCTITCTA AATATITTGT TTCTACCAAA ATATGTC CCAATITTGC C'TTATGGC TATTTCTTCA TATCCAC=fT CCCAAACTAA AGAAGCAGCC CCTTCACCTT AAACTCCTCC TTCAAAGCAA CCTAAATACA GGTCTGGGTT TGTATTCCTA GTGGGATGTT ACAGAGGTTA GTGTGATGCA GAGGAGGAGT CATGCTGT AAATCCATAC TAGTCCCCAG AGGCCAGGCT GCTTCTGCCA CCCCTACCCC TCCCGCCACA GAGCTCTTCA GCTTCTCACA TTTCTAGTTC TTCTCTCTCT ACTITCATTA CCTTCTCTCT 11TITIT-1 CTTCTCATGT GCTCACGGGA GCAGAGAAAA TTAACTCCTC TAAGTTCT TAACACAGAG TGCCTTAATT ACATATTACT ATTGTTTGAG TrCCTGCCAA CACTACGTCT GTAGGGTCAC ACCTGCTATA TTAGAGGCTT ATCAAAAAAA GATAGCTC TCCTAAAAAG GGATITGGAT GCCTACTAAG ATAACTGGAT GCCAAGATAA GTITAACCTA ACAAACTTTA TTATTTAT TATTATTA'T ATTAGAGATA GGTACTrAT CTGTCACCCA GACTGCAGTG CAGGGATGCA ATAATAGCTC ACTGCAGCCT CAAAGTCCTG AGTTCATGCA ATCCTTCTGC TTCAGCTCCC TGAGTAGCTA GGACTACAGG CATATGCTAC TCTGCCCAGC TACTTAAA AAAATAATrA GGGATGGGGT CTTGTTGTAT TGCCCAGGCT CGTCTCAAAC TTCTGGTTTC AAGCAATCCT CCTGCCTTTT ACCTCCCTAA TTGTTGGAGT TACAGGCATG AGCCACAGCA CTCAACCAAG ATTTAAAAAC TTTTAAAAGA AATCACATTA CTACTGTrA TCATCATTAT GGTTACTACC AGTGTTAAAA CAATTGGTAT TGAAAACACC ACTACCAGAT CAAGCTTCAA ACCAAGATGT CAAGTAAATA TTATTGTCAG ACCTCTGAGC CCAAGCCTGC AGGTATACAC CCAGATGGCC TGAAGCAAGT GAAGAATCAC AAAAGAACTG AAAATGGCCG GTTCCTGCCT TAACTGATGA CATTCCACCA TTGTGATTTG TTCCTGCCCC ACCTGACTG AGGGATTAAC CTTGTGAAAT TCCTCCCCT GGCTCAGAAG CTCCCCGACT WO 00/09525 PCT/US99/1 7712 EPI-109 51 GAGTACCTTG TGACCCCCAC CCCTGCCCAC AAGTGAAAAA CCCCCFIGA CTGTAA'If CCACTACCCA CCCAAATCC7 ATAAAACAGC CTCACCCCTA TCTCCCTTCG CTGACTCTCT TITCAGACTC AACCTGCCTG CACCTAGGTG ATTCAAAAGC TFrAT'TGCTC ACACAAAGCC TGTrGGTGG TCTCTTCACA CAGACCATGT GACAM1TGGT GCCGTAACTC AGATCGGGGA ACCTCCCT7G GGAGATCAGT CCCCTGTCAT CCTGCTC1T GCTCCATGAG AAAGATCCAC CTATGACCTC TGGTCCTCAG ACCAACCAGC CCAAGGAACA TCTCACCAAT TrrAAATI'GG GTAAGTGGCC TCIT1TACT CTCTTCTCCA GCCTCTCTCA CTATCCCTCA ACATC'=CT CC7TCAATC ITGGCACCAC GCT[CAATCT CTCCCITrCCC TTAAMTCAG TTCcrrrTr TITTCTGGTAG AGACAGAGGA AACGTGTrCT ATCTGTGAAC CCAAAACTCC AGCACTGGTC ATGGAC117GG AAAGACAGTC TTCCCT7GAT GTI17AATCAC TGCAGGGATG CCTGCCTGAT TATTCACCCA CATTrCAGAG CTGTCTGATC ACTGCAGGGA CGCCrGCCTG GATCCTrCAC CTTAGTGGCA AGTACCACrr TGCCTGGGTG GCAAGCACCA CCTCTCCTGG GGGGCAAGCA CCACCTCTCC TGGGGGGCAA GTACCCCCCA ACCCCTrCTC TCCATGTCTC CACCCTCTCT TCTCTGGGCT TGCCTCC ACTATGGGCC ACQT7CCACC CTCCATTCCT cCICrCTC CCTTAGCCTG TGTTCTCAAG AACTrAAAAC CTCTTCAACT CACGTCTGAC CTAAAACCTA AATGCCTFAC T 1TCTTCTGC AATACCGCTr GACCCCAATA CAAACTCAAC AATGGUrCCA AATAGCCTGA AAACGGCACT TTCAA TrCT CCATCCCACA AGATCTAAAT AATFTQ1X1TC GTAAAATGGA CAAATGGTCT GAGGTGCCTG ACATCTGGGC A FTC=fAC ACGTCGGTCC CTCCCTAGTC TCTGTrCCCA ATGCAACTCA TCCCAAATCC TCCYrCFrC CCTCCTGCCT GTCCCCTCAG TCCCAACCCC AAGTGTCGCT GAGTc=rCC AATCTTCCTT TTCTACITGAC CCATCTGACC TCTCCCCrCT TCCCCAGACT GCTCCTCCTC AGGTCGCTCC CCGCCAGGCT GAATCAGGCT CCAA'11CT7C CTCAGCGTCC GCTCCTCCAC CCTATAATCC F7CTATCACC TCCCCTCCTC ACACCTGGTC CAGcTTACAG ITrrCATrCTG TGACTAGCCC TCCCCCACCT GCCCAACAAT T7CCTCTAA AGAGGTGGCT GGAGCTAAAG GCATAGTCAA GGTTAATGCT CCTI=CTr TATCCAACCT CTCCCATCTC AGTTAGTATT TAGGCTITI TTCATCAAAT ATGAATACCT AGCCCACTCC ATGGCTCAIT TGGCAGCAAC TCCTAGACAT =TACAGCCT TGGACCCAGA GGGGCCAGAA GGTCAT=TA TrCTCAATAT GCA=I1ATT ACCCAATCCA CTCCCAACAT TAGAAAAAGC TCCAAAAGTr AGACTCCGGC CCTCAAACCC CACAACAGGA CITrAATFAAC =~GCC=CA AAGCGTACAA TAATAGAGTA GAGGCAGCCA AGTAGCAACA TA'TIN2CTGAG 'FrGCAAfl7CC 7rGCCTCCAC TGTGAGAGAA ACCCCAGCCA CATCTCCAGT ACACAAGAAC T7CAAAATGC CTAAGCCACA GTGGTCAAGC ATI'CCTACAG GACCTCCTCC ATCAGGATCT TG=TCAAGT GCCAGAAATC TGGCCACTGG GCCAAGGAAT GCCCTCAGCC TGGGATTCCT CCTAAGCCAT G'FrCCATCTG TGTGGGACCC CACTGGAAAT CGGACTGTCC AACTTGCCCA GCACCCACTC CCAGAGCCCC TGGAACTCTG GCCCAAGGCT CTCTGACTGA CTCC7TCCCA GATCTT=G GCflAGTGGC TGAAGACTGA TGCTGCCTGA TCGCCTCAGA AGCCTCCTGG ACCATCACAG ATGCT=IGG TAACTCTTAC AGTGGAGGGT AAGTCCGTCC CCT-rCTTAAT CAATGCAGAG GCTACCCACT CCACATTACC TrCTCrrCAA GGTCCTG'T7 CCCTIGTCTr CATAAATGT7 GTGGGTA77G ATGGCCAGGC rCTAAACCC =TAAAACTC CCCAACTCTG GTGCCGAMF AAACAACAFTr CIT=ATACA =FCIT1TA GTTATCCCCA CCTGCCCAGT TCCCT7ATFA GGCTGAGACA =IIAACCAA ATTA'TGCT TCCCTGACTA TTCCTGGACT ACAGCCACAT CTCATrGCTG CCCrCrCC CAACCCAAAA GTGGCAACTC CTIGCCACT TCCTCTCATA TCCCCCTACC 'FrAACCCACA GGTATGGGAC ACCTCTACTC CCTCCCTGGC AACAAATCAC ACCCTCNI1TA CTATCCCATT AAAACCTAAT CACCCrrACC TGGGTCAACG CCAGTATCCC ATCCCACAAC AGGCTITAAA GGGATTAAAG CCTGUTATCA =TGCCTGT-r ACAACATGTC CTI=AAAGC C1TGTAAACTC TC=~ACAAT TCCCCCAn7T TACCTGTCCA AAAACTGGAC ATGCC=TACA GG TrAG1TCA GGATCTGTGC CTrATCAACC AAA FrGT=~ GCCTATCCAC GCCATGGTGC CAAACCCATA TACTCTCCTA TCCTCAATAC CTCCCTCCAA AACCCCTCCA TAACC=TAT TCTGTTCTGG ATCTCAAAAC ATG==TCI TACrATrCAT 17GCACCCT CATCCCAGCC TCIrCUCACT 7rCAC=GGA CTGACCCTGA CACCCATCAG CCTCAGCAAC 17ACCTGGGC TGTACTGCCG CAAGGCTrCA TGGACAGCCC CCATTACCTC AGTCAACCCA AATITTCT TCATCCAT7A CCTATCCAGG CATAGTTCT7 CATGAAAACA CACGTGCTCT CCCTGCTGAT CATGTCCAGC TAATCTCCCC AACCCCAGGA CTGGCAAATT GAC=rACTC ACATGCCCCA AATCAGGACA CTAAAGTACC TCTTGGTCTG GGTAGACACT TTCACTGGAT AGGTAGATGC C=rCCCACA GGGCCTAAGA AGGCCACCGT GGTCATITCT TCC=TCTGT CAGACATAAT TC=TGGMF GGCCTCCCA CCTCTATACA GTCTGATAAT GGACAAGCCT TFIACTAGTCA AAGCACGCAA GCAGMICTC AGGCTCTrGG TATrCAGTGA AAC=~CATA CCCCTrACCG TCCTCAATCC TTAGGAAAGG TAGAACTGAT TAATGGTCTrTTYAAAAACAC ACCTCACCAA GCTCAGCCTC CAA=TAAAA AGGACTGGAC AGTACITA CCACTGCCA TTCTCAGAAT TCGGGCCTGT CCTCGAAATG CTrACAAGGTA CAGCCCA IT AAGA7rCTGT ATGGACGCTC C7T=ATFfA GGCCCCAGTC TCATI1CCAGA CACCAGCCCA AC'TGAACTG TGCCCCAAAA ACTGTCATC CCTACAATCT TCTGTCTAGT CATACTrCCTA TTCACCATTC TCAACTACTF GTAAATGCCC TGCCCTT TACAGTGCTG A'IMATAC'rr TTCCTCCAAA CCATCATAAC TGATATCTCC TGG=IIACC TCAAACCGCC ACCMTAAGT CTCTCrrAAA GTGGATAGAA GATCT'rCAGT GACAAGGTAC ACTCCAATAC T17CACCCTA ATAAAGCCCT A'Tr=ACT 'TTATA17CA CTCTTAT7CT TGTrCCCAT-r =TATGCCAC TCTCTACCTC TCCCCAGCTA TCTCCACCAC ACTATCAATC TCACTCACTC TCTCCTAGCC AITTcTAATC C=r1TAAC AAACAATrGC TGG='~ACA ATrCTCI I CCTCCAAAAT CACCGAGTCC TCAA'1TACT CACTGCTAAA AAAGGGGACT CTGCATA'IM T7AAATGAAG AGTGTGT= TF7ACCTAAAT CAATCTGGCC TGGTATATGA CAACATAAAA AAAACTCAAG GATAGAGCCA AAAACCTGC CAACCAAGCA AGTAATI7ATG CTGAACCCCC TTGGGCACTC TAATTAGATG TCCTGGGT7C TCCCGATTCT TAATCCTIA ATACCTG='Fr7rCTCCTrr CTTATGCAGA C=TGTGTCT TCCATT7AGT 77CTCAATTC ATACAAAACC GTATCCAGGC CATCACCAAT CATCTATAC GACAAATGTr 7rAAGGGAGG AGACCACCCC TCATATTGTC ITATGCCCAA 'TTCTGCCTC CAAAGAAAGA AGTAAAAATG AAAAGGCAGA AATGAAATCC ACAGGCAGAC AGCCTGATGC CACACCCTGG GCCTGGTGGT TAAGATCAAC CCCTGACCTA ATCAGTTATG TrATCTATAG ATTACAGACA 'TTGTATGGAA AAGCACTGTG AAAATCCCTG TCTGT7CTG 'TCCTCTAAT TACCAGTACA CGCAGCCCCT AGTCATGTAC CCCCTGCTFTG CTCCCCCTGC TFrGCTCAATC AGTCATGACC CTCTCACGCA GACCCCCTTA GAGTTGTAAG CC=TAAGAG GAAAAGGAAT TG'TCACTCG GAGAGCTCGG TTFGAGAC ATGAGTCTTG CCAATGCTCC CAGCTGAATA AAGCCCTrCC rrcrrrACT CAGTGTCTGA GGGGTITGT CrGTGT=TG TCCTGCTACA GTMTCATCTA ACAACCCCAT AATATCACCC CTACCACAA AATCTrCrr CAGCTTAATC TCTCCCACTC TAGG'ITCTCA CGCCACCCCT AATCCTGCTC GAAGCAGCCC TGAGAAACAT CGCCCGTTAT CTCTCCACAC CACCCCCAAA AAT1TCACT GCCCCAACAC TIACCACTA =FCGT1TA 7TfFCTTAT TAATATAAGA AGATAGAAAT GTCAGGCCTC TGAGCCCAAG CCTGCACGTA TACATCCACA TGGCCTGAAG CAAGTGAAGA ATCACAAAAG AAGTGAAAAT GGCTGGTrCC TGCCTrrAACT GATGATA'frC CACCATTGTG A'IT~rCCT GCGCCACCTT GACTGAGGGA TTAACCTTGT GAAA FrCCT7 CCC~rGGCTC AGAAGCTCCC CCACTGAGCA CCTTGTGACC CCCACCCCTA CCCACAAGTG AAAAACCCCC FrrGACTGTA A=IICCACT ACCCACCCAA ATCCTATAAA ACAGCCCCAC CCCATCTCCC 'ITTGCTGACT CTATITIGG ACTCAGCCCA CCTGCACCCA GGTGATTCAA AAGC'ITCATT GCTCACACAA AGCCTGIT7G GTGGTCTCTT CACACCGACA CGCGTGATAA T7A77ATA7T ACTITAACT AAAACCC1T CAGAGTCTCG CAGGGAAGGC TGTATATATC WO 00/09525 PCT/US99/17712 EPI-109 52 TCATAAAATG TTGGGGCCCA CTGGATCAGA CAAGGCCACA AAGGCCAAAG GGAAGTAAAG ATCTCATTAT TTCTCCTAAT AATTTCCCTG TCCTGTCA TAAATGGTGG GTAGGCTGTT ATGGTGATGG CAGATTTTCT TTCCATAAAA TGTCCATAAT AGGACATTTG AACAGAAGGG AAAAATCAAA TTGCTGAAGT TGAAAGAGGG CAATGCAAAG AAC'TGGAG AAAGAACTGT ACAGAGAAGT CAACTGGCAG ATGGGAGGAA GTTTAAGGGG AAAAATATAG ATGTCTAAAG AATACAT1TA TrCATTCC ACAGTGCAAT TTGGACAAGA AGCCTCTTTC TrGCTrCTTT CTATTCTCAT TAAATCATTA GAGCTCAAGC AATCCTTCTG CCTCAGCTTC CCGACTAGCT AGGACTACAG GTATGTGCTA CTATGCCCAG CTAAT1TIT1 AAAAATTAGA TTTAATTTG GTGAACTATT TCTGTAGGAA ACTACAATAA TACAGCCCAG GCACATTGAT CTTGGGTGAA CAAATCAGAA GGAATGAATA ATTCTGTGT7 CCTGGGACTC TGACAATTTC ATGAACTTGG TACTCTGAGT AAAGCATAGG AGGAGT7ATT TCATAAAATG TGGAGCACAA TCATGTGACA AAGATAATGG GATCCCCATT TCATAAATAA ATCTGAAGTT CAGAGAGAGT AACAACTGGC CAGGGTCACA TCACGGAGAC AGAGGCAGGG TTCCCACTGA TGCCTCTGAC TCCCTGTCCC AGGCCCTTCC TCCTCCCGCA AGCAGAAGTG CAGGGGGCAG AGCTGACCCT GTGCAGTGAA AATCTGAGGG CTGAGTTCCT ATTGGAACAC AAGTGAAAGA CTTCCTGGCT TCTAATCTCA GGATAAGGAC TCAGAGCTCC ATCTGTTCCA GCCTTAGGAT AAGAACCAGA ATCTTACACC ATGAAAGCAT GAAAGGTAAG ATTTGAGTGA GGAAAAAAAA AAAAAAAGTC TGTGTITCAG ATTCAGTTCA CAAAGCAGTT TCATACTTAA GGTACCATCA CAATAACCCT GTGGGGTAAG CAAGGCAAAT TrCATFCTTG TTTATGGGC ATAGGAAGTA AGTCTCAGGG AGGTTAAGAC CAAGGTTCT GGAGAATT ATATrATGAA TCTTGATTTA TGGGATTACT ATTATGTAAT TCCTAAGATC ATATAGGAAT CCTAGAGCTT GAATATAGAA C ATTI1 AAATCTATAT ACATCATAAT TACAAGGAGT AGTGTCCATT TGGGTTCCTT GGCCCTGATG TGTTAGTGGA ATAAACATITT TrGTCAGGGT TGCCATGTGT GTCTGTGCAC GTGTGCACTG TACACCTCCA GGGGATGTAC CCTAAACCAC ATGAATGTGA TTGCACATC CAAGATTTAC AGTGTACTAT AGGGAGAATC TTTTGCAACA GC11TGCTA TAATACAGAA TCTGAGATGT CTTTGAGAAA GAAAAGTGTA ATCATTACCA AAAAATTATr CTCATAATGT GTGCAAATTT GTATGAAATC TATATTGGCC ATGGGACAAG GAGGTATT17C CAGCTAGCTT CTGAAAGGGC TCTATTCTCT CATAAGAAT7 CAGCTGTTGA CATTAGGTGA TATCTGCCCA GGTCATCAGA TGCCATAGAG AAAGAGGGTT TGCTGAAACT TATATCAGCA GTGCACTGTA TGCTCTTTCT GATTTATTTG AACATfCATT TATTGAGTGT CAAGTAATGC ACTAGATACT CCAGGGATCT GACACAAACT CTGCCCTGAA GGAGCATGTA ATCTCACTGG GGAGAAAACA AAACATATGA TAATCAAA ATAACAAACT AGGCAAACTA GTTAACACTT AAAAAGCAGG CTTATrCAA ATGCAAAATT GCATGTTACA GGGTAACCTT TCAGTAAGAA GCCAGGAAGA GGAGCTCATC ATGGGTrGGA FAGTAAAGG ACTAGTTATA AAAGAAGTGG TGGGGTTGAG GGAGGCCTGA GATGAAATTT AAAGAATATG TAGAATCTAG GTAAGTGGAT AAAAGGTCTG GGGGCAGGGG AAAGGAGAGC ATTTCATTGT GAATCAAGGA ATTTCTCCAC CTGTTTTAAC TCTCCATAT GACATCAAAG AGATGTCACT TGCAGCTAGC ATTTCAGTGA TGTTTCTTA CTAATAATAT CGTGATAAAA GAAACATTGA CTATAAGAAA TAGGAATGGG TCTCATAAAA GGAAACAGCA AAACCCCCAA ACTAAAAAAC AGCGCAGGCT ATITCTCTCT TCTCTCCTT TGCTTGGCAC TCATGAGATG CTAGGTGTGG AAGTCAGCCA ACTGAAAAAG AGAGGTGGCT GAAGAAGGTG GGGAGGCTGA AGCCAGTAA ATAGGATGGT CCAATTCACA GACGGCGAGG CTACAGTGCA AATAGGACTC TTCAACTTG AGCAGGACCC CATrACTTCA CTGGAGTTAG AAAGAAAGGA GAGCGTAGAC 71-ITrGAACT T7CTATAAGA GTGTACCTCC ACAGTATACA GAAGACGACG TGAAATTFGA TCTGCAAGAA AACTGAGTCC ATATTCACAT ATGTATCAAA TTGCACTTC ATTAGAAGT GTCTGTCATC AAGTACAGCA CTGAATTGAA ACTGAAAACA AGAGTCAAGA AAGAGCAAAG TCAGCCATCT TTATATTCCA CATGAATCCT TTCCCTAT GGTCTTATTT GTTTCTCCTC AGAAAAGACA AAAAGCTGAG CTGTATAAAC ACCTGTGGGC TGGGGGTTGA GGGATAAATG AGGGGCGAAA TGGAAGCTGA AGGAACTGTT GGTCAGGTAG AAATCTTCCC AGATGCACTG AAGGAAACAC ACTTCATGTT TGACGTAGGA GGTGCCACCA CACAAAACGT TTCATGGAAG GATTTAAAGG ATCTCATGAT TTTAGTATT CCAAGAATTT TCTTCACCA AGGGCGAT AATATGGGTC ATrCATACTG AAAGAAAAAC AAAAGATAAT AAGAGTTTAA AAATTGCAAA ACTTGGAGTG TTAGTAGTAA AGGTAAATAT TCATTAGAGA TGAGAAGAGG AGCAAGGAAA TGCTTTCAGC TGGAAATCTC AGACAAGAGG CCAGGCTTTA GGAACCTCTG AAGATGAACA AATGTAAGCA AACCCTAGTA GCAGCACTTC TCAGATTTC ATGTGCTTAC CACTCAGAGA TGGTGTTAAA ATGCAGACTC TGATTCAGTA GGTCTGAGTG GAGCCTGAGA TTCTGCACCC CTAACAAGCT CTTTAGTGAT GCTTATGCCA CTGGCGCACA GACCCCACTr GGAGAAATT TTGTGGTGCA TACGGTCTT GTCTCCAGAT CTAATGAGTC TGAAGGACAG TGTAGATGA 1T111AAAT TTATGTTTAT TTrAATTTAA TTTAATTTAA TATTATT TATITATT TGAGATGGAG TCTCACTCTG TTGCCCAGTC CGGAGTGCAG TGGCACGGAG GCAGCTCATG CAACCACGGC CTCCTGGGTT CAAGCGATTC TTCCGCCTCA ACTTCCTGAG TAGCTGGGAA TACAGGCACG TGCCAGCACA CCCAGCTAAT TGTATTT TTAGTAGAGA TGGGGTTCA CCACArTGGC CAAGCTAATC TCAAACTCCT GACCTCATGA TCCACCTGCC ACGGCCTCCG AAAGTGCTGG GATTACAGGC GTGAGCCACC GAGCCCAGCT GTAGATTGAT TTTGAGCAGT GGAAAGTCAA GGAATTAGAA GGCATGCTTA AATGGAAAGT GAAATrGGAG AAAATTTAAA CTCATGAAAT AGTGGTGGTT ATAAACTCGT GATAAATTAT ATCCTGGGAT ATAATTAAT GAGATGGTAA CACATIfAGT TrAAAGAAAT AAGTGACACT 1TTIGTGT GACACAACTG TCTTATTCTr GGAAAGGACA AGGAGAGAAT GAAATATGGT ATGTCTTCAC AGCACCTTC AAAGGGAGAA CCAGATTCTG AGGAGCTGGT CTCATGATGA ACTGTCAGGG TAAACCACAG T7CAGCAGCT GCAAATGTGC TGCCAAAAT AGAGACAAAA AAATGTTTCT GAAAACAAAA TTCACATAT GCCCTCCTCT GAGGTTGGCA TCATATCTTC CTGTGTATCT TGGGTGTAGC TTCrATCCTG CCAGAATTTA GACAGTAGAA ACCAAATGAG GTGATAAACA GAGTCATTTT GCAGAAGAGT CAAAATAACC CAGCAAGAAA TGAAACCACA AATGCCCAAG GAGTCATTCA TTCACCATTC AAAAGCTAAT AGAAATGAAC ACAAACTACT ATGAAAATrC ACCCAAGAAC TTAAAAAAAA AAAAAAAGGC TCATGGTGTT TAGTGTGATA GTATrCAT TACCTTTGAC TTGTTCTAAA AACACACCAT ACTTCTACCC CACCCTTCCT CAGTGCCGTC ACACAATGGT TCAGTGTGA AAAAAAAAAC CACGTTACTG GAAAAGGAGG GTGCCTGGGA CTTGCCACTC TAAGCTGGTA GTCAAGGGTC TTGAGTTCTA AAAGCATACG CGTTAAGAGC ATGATTCCTG GATCCAAATG AGTATGGATC TCAGCATTGC CATTATTGT GACCTCAGGC TATTTTATTT CTCTGTGCCT GTTTCTITAT CAGTAATGAA GATGTTCATA GACCCTTCTC CCACAGACTT AAAGGCATAT TTCATGAT AAGACATGTA AACCATTCAT AACAGTATAC AACATGGAAT TAATA TGA TAAAGGTTTA TGAT7ATTGT AACTAACTCT GTCACTTGCT CAAGGCCTAT AGAAAACTTA CTTAATTAGT TCAACTACAA AAAGAGTTTG AATGTGATAT CCACCAAGAT CATATTCAGA CCTAGAATTC TGTGATTCTF ATGAATrAAT ACAGCCTTGG TCAATAAATG AGAGCTGGGC AAATAATTCT TCTITGCTAG GCCTCTAG ACCATCTGGT GAAGCATTCA AGACTTATGT TATTGGGGCC AGCCTrCCTF TCCAACTTCA ACTCCACAAC TCCTCAATAA GCCATGGGCT CAAGAAAGTT CTGCTCAGTG GCCCCTGAAA AATGCTCA TAGTCTCACT ACCATACCAC TGCTTACACA ATTFCCTTCC TACAGACTGC CTrCCTTCC TGCITITCTC CATATACCTA AATCCTATCT ATTCTTCATA AGCAACCTTC TTATAACAT ITTCTATAAC CACCAAGCCA AATGACCTT TCCTTCTTAA ATATAGCACC CATTGGCCAT TACCATGCTC TGCCTTGTAT TITCTGATT rTTTCTTTC TATATTCCTG TCTTAACTCC CCAGCTAGGT AATAAT=TC CTGAAATCAG GGACCAGGCT GACTCCTCT GCTGTCTCAA GAAAGCTTAG CAGTCCAA CACAAAAATG TTCAATAAAC AACTATTAAT TGACTGATTA TAAAAAATCA WO 00/09525 PCT/US99/17712 EPI-109 53 GTGAACCATT AAACTTAATA TAGCAAMFG CTAGCATGG TAATTAGCTT 'I17GCTAATA 'FrCT-rCCAGC CAGTCTCTCC TCCTGTGCCT CAAGGACATC TT1AAAAAAAA AAAATCTAGT TGATCTG=T CCATCTAGTG GCAATTAAAA CAGGTGGTI'C CGGTAGCCAG AAAACAGCTC TGGGTAGAT7 GTGCCAGAAA ATAC'=CAC TCAGTAGGTG CGAGMTGAA AGAAATCrTC ACATCTGTGG G TrCCTGCC ACAGACATAG GGAGACCAGC CCAGAGAAAG AAGCC1TCC TCACTAGACT CCA'I=GCAC TAGTAAAGAG AAGACAGAGT AATTAAAAAG AATAAAAAGA ACCTCCACTG ATCGTACATC CTCATCCAGT TACCCTCC CCACTTCTCC TTCACAGCCA AACATITTAA AAGAGATGAC TGCTGTTCT GTCTCTA=~ TCTCATCCTC AGTAATGCTC AATG = GGC CGTCTGACCT CTGTCTIGAT GTCTGCACTG CAAATAGTCT CCCCACTGAC ACC=TGTFTG CATCCAGGGG ATA=TACTG GTTCTCTTGG CAATGTIGA AACCGTTCCC C1= =11GT 'TCCT7GGCA TrCATrACCC CACACTCI Ir CTCCTCrrTCC 117CTCCCTGC CTGGCAACAT CT=CATI CTC1TCCCT TAGGTGACTI' A'TAGATAAT GATGT~rCCTC TGGCTCCCAT ACTCTCTCCC AGGTCCTC11 CCA~rC=AA AGCACTCACA CCCTCCCTGG ATGATAGTAC CCACTCCTGA GATGGCAGT7 ACCTCCTGAA ATGTGAGGGA CCCAAATCCA CT-TCTCCTGC CATAGCCTCT GTGC=rGGA TAGGTCCAAT GAGCCACAGT GAATGATGTG CATACACCCA AAGCTCAGTA CAAAACTGAA CCCATGATCT TTACCTCCAA AACCTCTCAT TC'IIATGT TCCCTrCTCA GAAGTAAACA GGACrACCAT CCGCCAGTI7 CCAGGTGAGA AAGATGATAA T7GAT7CTT CTCTCTCACT TITAGCCAAT TAACAGACAC AT-FCAGT7AA TATCACCTCC T=IATI17CA TGAACCCATT CTACTACTA GTTCCCTAGA CAGGCGCCAT CGG=ITAAT CTAATAACrG CAAATGCCTC CAAAACAAGT CT=11GAAT CCAGGCTCAC CTGTCTCCCA CACTrGCCAT ACTGCTCTGC AGGGTGACCT TATAAGATGC CAGAGGTAAG GCTACTCACT G'1TAAACCC C'TIAGTGAT ATCCCAAAAG ACCTCAAGAT AAAGCCCATA TCACATGGCT TATACATTAG M~ATGATCT GG=TCTGGT GCCTCA=II TCCCCACTT T7CC1TGCA TTCTAAGCAA TGGCCCATAC TAAGTFITGTG ATTGGTAGGA TGGT7GCCCA AACCAGCATC CAATCCCTC AGAAATCATC TCA=~CA'IT TCTAGCAT TAAAGGAAGC TCAGITGTCC AGCTGGGTAC TGAATATGTC ACCAAAGTCC TCCTICATA G=FATITA C'F[AAACTCT CCTTCCTAAA A17CCAGAGC AAGTCACTAA ACCCTAGATA CTGAGAAATA TFFCCATC rrCAMrCTG CCAGGTGGGC CATCAAC1T CACATGTCTG CATCTrCCTCC CACTGTGCTA TTrCTCCAGT AGAAGAAATr TGAG=~CAA GACCAAACTG AAAAATAC= GCCTCCTTGG GGAAGCTGTA GGTAGAA'FIC ATGCTCCCTA TCTI7rCCCAC ATFFCTGAAG GACAATGCCT GTTAGAGCAA TTGAATGCAA ATAGTCAATT GAATAAGCAT TTA FrCAM~ CTCAATAAGT GCTGTFCAA 'FrGAATA'IM CTTAAATAAT ATAT11TAAGA ACAAGAAGAA CACACCACAA TG7IF=AAC CCTCAGAAAA AATrCTGAGG TAATCAGAAA AATCTCCCTT TACATAAACT GCCC1TICT AATAGGGATT ACTrGTTCGT TCATrCA'ITC A'FrCAGCTCC ACTAGCACCA AAAAGCACAG CTCTGAAAGG AAGCTAGTAG ATTI'ATCACC 77ATCTGGTC ATTTGGATGA GGACCCCAGG TAAATAAACT ACTATGGGGT TAATGTGTCT AGCTAGAGCA GGAAGTAACT TAAGGAAGTA GAGAATGAAT CAGCAGATGT GGAAACTCCT CGCCACTAAT AAAA=TACC TrCTCT[GGA TI7CTTGCCT GAAAATAGAA AATAGAGAAA AGGCAT7AGC AAAAAT7AGA CAAT7AAAG 'FTMCAAGT AAGGGAGAAG GAAGACTCCC ACTCTCAAAA CTGTCT=TG AAGTATAI17A GGTATI7rGTT AGGTGGACCC TATCTGTGTC AAAGGAGA11 TGAGGAACTG G=~AATAAA CAGTGGTAGA CACTAATACA GAACAGACAT GTrGATGCAG ATGCCTCCTG AGGTrCCATT CCA I1CTCCG TGCTACTCAA GAAGACAGAA 25441 TrGCTAAATT GCCTGGTGGC AAGACCCAAT ATGTCCAT7C AAGTGMTAT CCCTrCCCAA TCTGCCATCT CATCCTACCT GCAGATr=T CC=TGAGGG ACAGCTGCTA ATACTGTAAA ACTATGTGCC ATTACAGCTC ACAGCATCAT CTCTATGAGA ATCCACAAGA GAA ITCACT TrGGT=TGT TGGTAGGAAT TGTGCAGCCT CATCTGAGTA ACTAATGTGT TATCTA CAAACACAAG GAATATCACA TGGTTCTCCT TFfGACrGGCT GTAAGGAAAC TCAGAGCTAG ATCTGAGACC CTCTCCTACC AAGTATATAA AA=T1GTGA CATACNFI= TGTGCCATAA =~CAACCMr GGTTCCAAAT GATI=rGTA CCCTAAGTI7 AAA ITGGC7TTCVrflTTIT fT GTA CTCAATAAAA CATCAAGCTC ATTA TAT7 GCGAAGAGCG AAACAACAAA GCcTTCCACAG CGTGGAAGGG GACCCGAGTG GGTrGCCCAA ATTGGCTTCT 7IrCTrACT =1TAATTAA T1T7AAMTG CTATACTGAA CACA=FTGT ACTGTFrCTCA CATrCTTM GAAAAAAGCA GAATATAAAT AAGTAGATAA CTrAAAAAAA ACTCITGAG CAGAAAGAAT CA'IMGGGAG GCAATATAIT TCAGTGGCTG TAAAGTGGCA 'TTCTAGAATC ATCCTACCCA GGTGAAAGCC CTA=IIGCC ACCTGTAGTG TAGTGTGTAT TFIGAACAGCT ACn7~CTI= CTAAACTACA AM=CTCAT CTGF1TAAAGA GGCATAATAA TTGTATCATC CTCAITGGGT TGATAAAATA AAATATCC AAGTATrTAG FrCAGGTCCT AGCACGTAGA CAGTGTI'GCA TrACTGFI= AATCCM~AA AGTATrAAAG ACTACTAMf GAAATCI I I I CTAAAAT TCAGCCTGCT GATGACCAAG TGCACTGAG CAGGGGGAAT CAAATCTGAA 'ITAAMIICAG AT7CTGG'FrA GC=CACATA AATATIT1 TT AGGGATGA TGAACCTAAC AGCAATAGAT GAGTAAGAAT CTG~rCCTAC TGAGAGAGTT TCAT1TGAA GAAAAAGGAA CTAAGGGGGC ATGTGTTCAG MICATGCCC TGGTCTAACC CTGTGTGTTG GTTCTGGTGG GAAATrCTrC CAACCGAGGA AAAAACCAGT TCACAAATCT GAAGACCAGT GATITAGAA GATGTATCTG GACTGGAGTC TAATCTCTGA CTCTGGGTCC TGCTGATATG GTATI=GA GA'Tr7GGCCT AAAACATCAT TGCCCTGGTT TC=~AM~A CCAAACAGGG CCAATGGTAG TGACTAATCA GAAAATGATA ATGCCTGGTG CACAAAATGT GTCTAGATGA GCCCATGCAC AAGGACACAT GT[CTGGAA CTGTrCCTrA TrCC1TCCT AAAAGAAAGG AGGGAAAGTC TCCATACTAA GACTACTAGG GCAGGGGACA AAGTGCTAGA GTCAGAAGAT TCATCTGAGG ACAGAAGAAT AGGGGTGAAG GCTCTAGTCA C'ICAT7GGC TACCATGCTC TAAATAGTrA CCTGTGCCCT TTICTAACT ATTAGAACCC AAAAAGCCTA TAAATrCTCT CTCTCTCTCT CTCTCTCTCT GTGTATATAT ATACATATAC ACACACACAT AGACACACAC ACACACCTAA ACACACACAT AGAGATITAT GAC7rI=AC FI=ATCCTI GTAAATGCCA T-FAACTATAT MTGTCTTAG A'IMAGCCTG GGAATGTAGC CATTATI7CT ACCATrGCCT CCATAGGAAA AATACTC7rC ATGT1TAAA GGACCAACCT ACAACTAAAA TCMIGGAAA GCAGAATCAT TrGTAAGrrG GTGAAAATGG AAGATGTTGT TI7ATAAATG AAGAC'IrI TFTITITIT TIGAGACA GGGCCTCACT CT'GTrGTGGA GTGCAGTGGT GCTGTCATGG CT7ACTGCAG CCTTGACCTC CTGGGTFCAA GTGATCCTCC CACCTCAGTC TCCTGGGTAG CTGGGACTAC ATGTGCATGC TACCATGCCT GACTAATIT TTGTArTT GTAGAGATGT GGTTTCGCCA TGTTGCCCAG GCTGGTCITG AACTCGTGGG CTCAAGTAAT CCTCCTGCCT CAGCCTCCAA AAGTGCTGGG ATTAGAGGTG ACAGCCAAGG TGCCTGGCCC ACAGATGAAG ACTA'TI7AAT GTTATCTEAA AGATACCCTA AGCTrCCTAC CAAGCCAGTG ATC71TGGG GCTrCTGT1T TC'ITrTGG CATAACTGTA ACTAGCCTAA CTGCCCGT7A TCTGTICCT G'TTrGCCCCA CACTGATTCC CACAGCAGTr TFCAAG FrAT CGGTI7GAGA TCTITGTACAG AAATGACTCC AAGGTAAAAA AT7AAAAAC AACCCCTCTA ATITrAC CCTGCTAT AAAACAGCCT TAGCCAGCTA ACCCCTCACT ACATGCAAAT GAGT17GAT7 CTATrC1IT GATrCTACAA ACA=TT~fA AAAGATT=A GAATTCGGAA ATAAATAGCT TCCTT~AA GGTGACTAC AGCCCCAAAG TCCTTAAAAT TATfl'AGACA ATAGCCACCT TATCCCAGGG GGCAGTGTGT AATAACCCAC CCTGTrCrCT ATCCGTCAGT TCTGCCATCA TCGCCCAAGG TAGGAAGAAA GACAGGACAA CCGGGGTCAA GATGAAGT CTCAATGGAA AGAATAATCA GTGG17GGAG AAAACTGTCA TrCTrCTr GCCTAATGC AGTACTGAT ACTATACT AGTACTGTAT AGTAC=AGT ACTGTATAAT ACTATAAGAT AGTGAGA'FfC AATCAGCACA GAAT1TrCTAA TAGCAAGGGC AGAGACATF TAACTGCTCA GTGCTCTCAG G'F1ATACATA GCTAATGAAG TTCTrGCATA WO 00/09525 PCT/US99/17712 hP'-109 54 TCAACAATCC CCACCCCCCT CACACACTTT GTCTTTCTGG ATTGGTTAGA AAACTTACCT AGCGCCCACT ATTCTCAAAT TTAAATGAAA GATAAGATCA GAGTGGCACG CAATTAGGGA CTGATAAATA ATATTGT AATTGCCAGT GTAAATGGAC AGGGGGCAAC CTTACATAC CATATTCAGT GAACAGAATA CGTACTAACT AATGATGG AAGGAAAATT AAAATGACAA TCAACTGAGC CCACAGAAAG GCAACACAGA GCAGTTGGTT AGCAATTGTT TCGAGATCAT CCCTGAACTT GAAACAGGTA TATCTT1- 1-1TIT1T1 TTGAGACAGA GTCTCACTCT GTCACCAGGC TGGAGTGCAA TGGTGCGGTC TCAGCTCACT GCAACCTCCG CCTCCCGGGT TCAAGTGATT CTTCTGTCTC AGCCTCCCGA GTAGCTGGGA TrACAGGTGC CCGCCACCAC GCCTGGCTAA TITGTATT TTTAGTAGAG ACAGGGTTTC ACCATGTTGG CCAGGCTGGT CTTGAACTGC TGAGCTCATG ATCCGCCCGC CTCGGCCTCC CAAAGTGCTG GGATTACAGG CATGAGCCAC CACACCTGGC CAAAACAGGT ATATCTTAAA AGCTGCCCAA TGTCCATGAA TGTTACAGCC TFGAATGGTT CTTCCAGGTG AGTTTGGCCA AATGTGGCAC CATACACCCA AGGCCTGCTG CAGGCTAGTG GGTTGCTCAC ACTAAAGC TGAGACACAC TCATGCCTTA AGGTAAAGGG AGTGATAATC TGGGCAGCAG ATGTTAACTT CTCAAGGCAG TCCTCCTTCT C1T1CCTCT CCAGTGACGG ATGGTTGGAA AGCATATATG GTGCATGG TTAGAGCTGT GGCCTTGGTG AATAGATACT TGGGAGAATA CATGGGAATT TCTCCCAGGG TrAATGCAAT GCCCATGTGT TGGGAACCAG GTGACTC7TG AAGAGGTCAG GTATTTGGGA GCAGTGCCTT GAAACCTTAG TGGACATTAG ACCCACTTCC TAGTGGAATT GTAGCATTGA AATCCAAGGC ATGTAGGCTC TTAGAGGACA GAGATAGTGT GTCATITIT CAGAATTAAT TAAGAGCAGG CCAGGCGTGG TGGCTCACAC CTGTAATCCA AGCCCTTTGG GAGGCCAAGG CAGGCAGATC ACGAGGTCAG GAGATCGAGA CCACTCTGGC TAACACAGTG AAACCCCGTG TCTACTAAAA ATACAAAAAA TTAGCTGGGC ATGGTGGCAC GCTCCTGTAG TCCCAGCTAC TTGGGAGGCT GAGGTGGGAG AATAGCTTGA ACCCAGAAGG CGGAGGTTGC AGTGAGCTGA AATTGCACCA CTGCACTCTA GCCTGGTGAC AGAGTGAGGC TCTGTCTCAA AAAAAAAAAA GTATTAAAGA ATTACATAAG AGCAAAGAAC CATTAGAATA TCTCACTrAG TTGTrATCAG CCTAGCAAGC TGCCTTGAAG GTAATAGACA ITITIAAAAG TTATCAGAT GAAAAGCGAA AATCAGCCAA CCTGTITTAA TGAAGGTGTG TCCTGGGCTG ATTTACATGT CTCCAGGGAC TGATGGCTCT AGAATGTAAA GCTTGGCATC CTGCTTGTGT TGAATCTATC ACATTTAATT TCCTGTGGGT TTCT1111 TCTITIC ACTTTAAAGT TGTGTTCTT TCATGTGAAG TTAAACTCAC ATACCTTI TTAATCTCCT TGCCAGCCAA ATGATAAATG CCAACCCAGA GAATGCAGTA ACCATGACTG CCACTGGAAT GAAGAGGGGG TTATAATCAC CCTCCTrAAT CATTGAGAAA C11 IGTCCA ATTCTGAAAG AGAAATCAGT AAGGCACATA GCATGAGACC ACCAGCATTA TTTCCTTAGT CTATCTCATG ATATTTGACT TTCCTCC TTACATCTCC CAGTAGTAGC CCATTTGATG CCATTTGACA GATGAGGAAA CTGGCATGGG AAGGCCCCTG ATGAGTCTAC AGCATAGGCA AAGACTGGAC CAGCCTTGCT AGTCTAATGC CTACAGAATC TCAATGCCCA GATTTGTGGT TCATAGAGTr CCTGAAAATG CACCTAAAAA TGTTGGCAAG AATGGTCATC GTTGTATTA GCTCCATGGA CTTGTTCAAT GACTGGAACT CTGAAACACA GAGAAGAGCT AAAAGCCTAA TACAACTTCA GGAAAAATAA AAGCCAATGA TCTGAACTGG ATAATTCACC AGTCAAAGGA AATCATTAAT GCTTTTACTT TAAAGCAGTT GTGCAAAAAT AAGCACTTGA 7111ACATG CCAAGGACCT GCACTAATTT CTTTCCAATG CAGTAGTTAC CACTrCCCTC TACTTCCTTC ACGAATAAGT AAAAGGGCAT G'TTTAGAGAT ACTCTTGTAA GTGTAAACTA AGTTCATTG GGAGCCTCTA TGAAAATA CTGGTATAAA AAAAAATCTG TCTCCTGATA CTAACATG AAGGAATCTA CTITITIACA TATrGGCAGA GGGTCTGATT CTATCCTTAG TTCTrCCCAT TACTTTGATG AACCiTICA AGGTGAITG ATCCCCACAC CCAAATATAT GATTGAGAGA AGGCTCAAGT TCCCAGGAGC TCCAGACAGA AGGTACCTGT TGGCTTGATG AAGATGAGGA GGAAATGAAC ACTAGCTAGG CCTTAAAGGG AAATGTCTCT GATAGGCCTA ATACACAGTC CTCTGCTAAA GGCCTCCCTG CCTCTCTCTG CTCATCCACT CTACTCCCTG GCCCTGGGCA CGCAGCACAC AGAGATCAGC ATTTCTGACA GCTTCTGTAG ATCCTACCAT TTAAAGACTT TTGTCATCCA TGCAGATAGT CTCAGGAGCA GACACAGGTA GCTATTCTTT CACATGCTAG CTTAACATGC ATrTGCTTA GCACCTATTG CCAGGCACTG TGTCAGGTGG AGGGTATACA AAGATGAACA AGACATGATT CTTCTCATAT ACAGATAGAT TrTGGAGGCA TTAGCTTAGT GATGATTCAG GAGTATCCAT TATTGGGGA AGTAGGTGGT CA1AGTGAC Ci IrACAGG CATTTCAATG GGCTAACAGA GATGTrAGAT TGTAGTGGAA TAGAAGAATG GGTAAAAAGT AAATCAGTGA GTTCAGATT TAGGAGTTAA GATGGCAAGA GGTGAGAACA AAAAAAGGAA ATGATTGTCA TTAAAGGAGG AGGAAAGACC AGCCAAAGAT TTACAGTGA GTTAAGCATA CAAATTTATr TCTAGGCCAC ATATTCTTAG CAAAACAACA TGTAAATGTT TATGTATGTC TTrCCTCATA TCTGCTCATC CATCAGCTCC ATCGTTAAGA TITTCAGTTTT CCAGGACAAA CTTACTCACT TTGACATATT GGACTAGGAT TTGACCAGAT TCCAGATGAT TCACAAATGG TTTCTTCTT CCCAATTAAC TCAGTTCCTT CTGAGCAGAT GAAGGTACAT GCAGAGGTAA AGCTGAAGCT GGCCAGGGGA TGGCTACAGT TCATGATCCC CAAATCTGGT GCTGATAGAG GCTCACACTG AATCACTTCA ATGAAAAAGA AAAAAAAAAA AAAGACAAAA CAGTATTTCT GAGTAGAGAC CCTCCCTTGA GCAAAGGAT7 TTTAGCCAAA GCTGCCTGAC TACATTACTT GTGATATTGC TTCCAGGCTT TAITTCTrG AGAATGATGG TGGGTGGTGA ATGAGAGATG AAGGCAAGGA AGCATTGAAA GCTGTGGGGA GAGGAGTAGC TACTCCAGGC TGCTGCCCTA GCTAAGGTGA CCCTCCCCTT CTGCTGGAAG TACCATGCCA TATGGCCTCT GCATCAAGGG CTCTTATGGG ATATTCTCAG AGAATCTCTG CCGTTTCATC TGTTCTGATA TCTACCCAAG CATlilGAAA AACATCCCAA TTCACTGAAG CAAGTCCAAC TTCCGTAAAT TCCAGTAGGT GGGTTGACAG T=TATAATT TCAATAAGGG ATTITGATAG CACTTCTAAG AATTAAACTA CTTAAACTAA TGCATCAGGA GCATACTTGT AGAAAAGTTA ACCAAAACTT CGTAAGTTCA GATGACATTG GTCTCCC ATATGGAGAT AAGGTTGGCA GTTAAAAATG AAAAAAAAAA AAAAACCTAC CTTA'TTCAA ACTTGAAAAG ATCAAGAGAT TGTGlTI-iG TIT11CAGTT GTTATfCTCC TAAAAGTTA TGCATGAGGA AAAGTAAAAG TGAT=AAG AATAAGCCAA ATAAAACAAC CAAGAAAGAC CTCCACTACC CTGGGAAGGA AACTGGTTGG TATTAAGTAG GACACCACAT AAAACAGGTG TTATTGAGAG GAGAAGAACC AAAATGTAAC TGAGGTTCAA CAAGACATrA TTTATGCAAT GGCAATGAGA AAAATAAAAA ACACAGTATA ACCATGCTGT ATTGCTATAA GTCATGTTAC ACACTGGGAG ATGGCTTCAG GGGTATGG TTTTACT TTGTITGGGA GGTil-1CAA AAAAAITTAG TTAGAATAAG TCCTTTGAGA AACATCACAG TAGGTTAAAC AAAGTTAGGT TAAATTAGGC TCCTAAGTTT GACTTCTCAG CAAACTTCTA CTGAATGTTC TGACTGTAAG CCCAGGATTG CATGACAAAA CCTCTAGTCT GAAGT7ACTC ACCTTGACAG GTTGGTTCTG GAGATGACCA GTTCCAAAT GGTCCACAGG TGGMCTTC AATCCCAGTT AAGTGTTC CTCAGAGCA GCTGAAGGCA CACTGTGAGC TGAAGCTGAA GTTTCCCAAA GGGTGAGTAC AGTCCATGGT ACCCAGCTCT GGGGCCTCCA AAGGCTCACA CTGAATCACT TCAATAGGGA AAGAAACAGT ATGGGGAAGA GTTAAGAGGA ACTGACGCCT GGA'TTTGAAT CCTAGCCCTG CCACTTGATA ACCATGTGCC TTAAACAAG GTTACTTGAA CCCTCCAACT TCAGTCTT CATCTATATA AGAGGAATAA TGAAATTGTG TTATCTAT CAAATTGATA TGGAAACTAA ATGTAATTCA ATTAGCATAA GTCAAGGACC TTAGAACAAA GCCTGACTCA TCAGAAATTC TAAGTAAACA TTAGCTAGTC TTCATATrAT TATCTTCAGC ATTATCTGTA GTGAGAATCC TTAAAGCCAA ATAGGTGTAA CTGGGAATGA CCAGCTTAGT CGGGAAATAA CTATCACATC AGAGCCCCTG AGTCTACTAG AGTATTGGGA GCAAGATGTT CAGAGAAAGA GTGGGTCTCC ATAATAAGCC TTCTTGCAA GGAGAGAATA TAAAAGTCTA GGAAGCAT'17 TGACCTCAAT TCTGTCTTCT ATTCTAGCTC AGTTCCAGAA T11AACTCT 'TTGATTTTG ACAACCCTCT CCAGAAACTG TATCTATTTC CCTGTTCTGA WO 00/09525 PCTJUS99/1 7712 xrI-IU9 55 3TGGTGGTAC AATAGGTAAA T-rrAAGACTr GGAAATCAAA G T=CACAT M~AGACCCT GCCATGCCAT TTAIJTAAACA GTACAAC'= CATGTCTrAT TCCTCATCTG TCAAA'IMAA GCCA'ITATrG CTACCTrFGCT CTAGAGACTT CAAGGAAGAA TGGACTCAAG GAATCAGAAG AATITIGTA 'TrTGGAAACT ATATGAGATG AGAITFAGGGA GAAACATGGG AACTAAGAGA AAATGTrATC TT1TCAT7 GAM~AAAGA GTAT~rTTA TATATCAAG1C ATTACTCTGG GGCTTrGAAGA G=TAGAMI CACCCTGTAG GACAAAATGG TAGGTAGAAA UTAATGGGTG GATlGTCATG TATGTGTGAT GTGTITAAT TGC=T1AAT TGATCAGTCT CCCTGTAGTA TGAATAATGT ATI7GAGGGG AGCTAATIA AAATTGTGGA ACTCATCTAA TAAACTATrG CAAGAATCTA GAAGAAAGAT AATGACGGCA ATGGTAGTAG AGTTGACAAG TGGAAGACAA A31TAGAAAAA CACTAAGTrG TAAAAATTGG TAGAATGTTA CCCTGCATAA ATGTrGGGGG AcGrTAAGAGA GTCTCATACC AGGGTGCCCA TGTAAATGGT GA FrCCACAT ACTGAGATAA GAAATACGAA GAGAAAAGCT GACTGGGAAC AATTGGT1T ATAGTCTIT AAACATCCCA AAGGACATCC TrAGCATAT7 TGAGITCAGA GCTGGAGATA GGC=ATCAG TCCAAAGATC ACATAGA'TI7 GTGAGTCCcJC AAAAGTCAGT AAGnhrGACC AAAGGATACA TGTAGATTAG AGTCAGAAGA GCAATATACA AAAGACAAAA GCTGAGAAAT TATAGTAGTT TATGGTCCTG GATAAGTGCT CATGAAGGAT CTCAGGAGAA ATGATCACAG GTAGAAAGAA TGAGAAAAGA GTGATATGAG AGAAACCAAG ACAAAGAAAA GTAAAATGIT AAAAATGAGT GAAATAGGCA TACCAATAAT TAAAAATGAG TAAAATAGGC ATACCAATAA CATAAGGGTr AAAAAATAGA GTrCAAAAAT GGGGTGAGGG TAAAGTATTA GGAAGGAGTC ATGGCCCAGG GATCAAGTGA AATGAGTTAG ATCTATAGAT CTA TCAGT TGGTrGACAT TTAAATGTAT IT7GGT1TA A'TTTA~r G=~ACAAAC ATrGCr'FF TAAAAAATTFA AATTGTCCAA TTCAAT7CAG GCrCACAAGC AAGTGCCTCA TATATACAGG CATIGTGG ATCCCAAAGA TGCAATGATA AATAGGACAC TTACTGATCT CAAGAAGMT TCAGTACCAG AGGAGACGGA CAAGTGAACA GATGAC=CA ACATAAGTGG GAGAAATGAG GAAGAAATAT GTGGAGCTAT CAGAACTAAG AAAGCTrCCT AGAAGAAACT GTCTIGAAC AATGT=TAA AGATGACATG ITITTGGCC ATGTGCAAAA TGAGAGAGAA GGCCACCAGC AAAGTCAGTG TGCTACAGAG CACATGTG'rr AAGTGTGGAG AACTGCAAGA AGGAAAGGAA CTACTAGAAG GAAAAAGCAA GATACI=CT GGGTAACTCA GCCTCCTAAT GATAAATGGC ATAG'TrTCTT CCAGACCTrA GAGIT7CAAT TAATCTAACA AGCTCATTAG ATCGTGAGCT TC'IGAGAGC GGGAATCTAC CATGCTAATT CCTrATGGTA ACCCTGACAG CT1TATCCC AACACTGTGC TTCTTGTGGT ACTCAAAAAG ACTIGTrGAG AAGTGAGTCG AAACT]7CATG CTGAC=ATG AAATCTIAC GGAAAGGTAA CAATATrGTG AAAGCAGAGC =TCTGATCA AAACT'TCCCA TrCTCAGAG TGGCTAGTAT CA'TTGT7C CAACCAGCT CATGATAAGC TATAATGATT CCTGTGA=T TACCTAAGAA GAAGCAAAGA AAGGAAAGAG ACTTACCAAA CTGACACTGG GGCCCATAGT ACCCCACATC ACAGT[GCAG GTGTAA FTAT TGATGA T1C TACACArrFC7 CCATGGCCAC TGCATGACCA GGGCTGGCAA GAAGCT=AA GGAGGTCAGA AAAAAAATAT TrAATGTGA rTACATI=A GTACTCAAAG TCAIMrF= AGACATAGAT AACCT=TGT CTGAGATGAT TTAAATAATC AGGAAAGGT-f TAIMGTAAA TTCATAGCAT AAAAATCATA TGCTAAAAT7 M11ACGTATA AAATACACTA AGCATATAGT CATAGGCA Fr TATI1G='~ TGGAATGAAA TrACCAATAC TAATATTCTG TAACACT7AT AGGAAACTrA GTGGCATACC TTGAAACTCT TGAAATTACT TGITI=AAT GAGTGAGAAG G~FrAAATGAT GACCTGACCT CAATCAMC TGCATGCAAT TAT1=GG CAATCC=l~ C'TATAGAA ATCAAAGATr AAAAAGTCCA AATITGCTAA AACGGTAGAG TCCAATIAT AAGAGACCAA ATTAACTATG G~rCATTATrr AAAACATCAC T7GGAAAATG CTGGCTGT-17 TGGAATTGTA GAAGA=IrA CAGAAATATT CATACACCAA AGATAGTGCA ATTrATAT AAAATTATAT AAGGTTAGAC CAAGAAGGAA GCACGCAGCA CCACACTCTC TACTrCACAA TGTGAAAACT GAGGTGATGT GAGCCTAAGT F7CCAACTGG CCCCAGCTGT CAGCTTCTCC TCCCCTGCCT TATrATCAAA GGCACTGATr GTCTAGCTCT TCCT7CTGTAC T7CCTACGTA GATCTATCAT 'T1GATGTAA CTrTGAMPAG GGGTATAGCT T'IrGTGCACA GGGACAAATC T7ACACACCA AAAATrCT7A GGAGTGACAC GATGCAAGAT TATATAGAGG GCTAGATGTA FITAGAATG AACCAGAAGC TGT7CTCATC CCCCCACCTr TCCATGGGGT AAATCTGAGT ATIXcTIlAA CCGTGGCCCT TCCTGAGTCT GAGGCAGCAT AGCCGT=TG TCACTCCCTA CCTGTGTAAC AGAGGGCTGC CT=AGMTG TGGCAGGCGT CATCGTTCCA TPGCCTGCA TC-=GM~C TCTrGATATA GATCTCCACG CAGTCCTCCT TG~rcTrC= GTrG'FrGGGC TCACCATCTC CCCAGTrCTC TGCTTCTrCA GTAAGAGATT TGTTGGTTCC CACCCACGTC CATAT7CCTC CTATCT7CCG GATTrCCTATC CAGTAGTAAG AACGACTGAA AGGCAGAGTC TI7CTCCAGAT ACTCAATrTC CGCCTTG'Tr TGTATGGCAA CTAAATCTGT GTAAITGTCT CGGCAGAATC TTCTAGCCCT 'TGCCAGTTC ATGGG'TI= CAGAATAATG GTAAGTCCAG CAGTCGGTTC CATGATGTGC CAGGAAATCT GCAAGACATC AGTGTGACCT ATGCAGACTr ACATAATGTT ACAGCTAAAA AGAACCTAGC ACTACTCCAG GCTGAGCTAG ACACYAGAG ATGAGGAAAC AGAGCCTAAG AGTGTATGTG ACCATCTCAG GATCACAGAA TAGTrG'ITG CAGA'ITrGAA GTAGAACCTA GACCTrCTGG CTTGAATATA AGATGCTIT ATCTAAGGTr CTAT'ITGAAA CAAATITAGT GGTITCTAG G'TI7A1TrC TrATTAATT 1TCTCAAA AT~TCAG GTGAAATIA ACCAACATAT T-JTAGACATI' CATA=TICT TTF1TGTA GCTGTrAATG A FFrACAACT AAT7ACCGTG TAATATCATA TAACTATACA AM~ACGTAT AC7IITAAT CCTGGAATCA 71TCITGAAG GCCAACACAT ATGTACCTAT GGGAGAAGCA TAATAAGGAC AGGAAGAACA GTGACATACT TITAAGTAAC CTCTI IIACA TAAAAAACAT TrA1TrAC CATAGGAAGA ACrGCTTCTG GAAAAGCCCA ATATACCACT CAACTCTrAT ATATCTAACT GTATAATIT TAAAAAGAAC AA'IMACAAA GCCAAATGGT ATAGGATTAT GAAATTCAT7 AGATCATGTr CTATACACAA AGAGACTCAA CTGATGATGT TrAATAAACA TATGGACCCA TCAAATATGA GGG=1IGAA GATATCTAAT TAAACACATA ATTACACAAT GACTrCATAA TAATATATGG CATTCTAAGC ATGGTATGAT CTACATGAAT CACTAMIAA TACAGTAAAG AAACAGATAT AATTGATGGT AAAGAGCATC ATAAAATAAA CATI=GAAC AGAGTI=GA ATGAGCA17C CACTAGAATG CAAGTrCTAA GAGGGAAAAA ACrGTTGTGT CCACTGCTGT ATCC'ITAGTG CCTAGCATAA AMTCACACA 'FrGTAGGGAC TCAGAAAATA CCTG'17GTAT GAAAAGAGCA CTAAG1T7CT ATGTGACACA GTGCAGACAT GGCATAAGGA ATGTGTGAAC GGGAGAGT7A GCATGTI7GC TGGCTAGAG CTGAAAATCC AGGCTAGGGA GAAAGAAGAC ArrAGM~AC ITAGGAAATG AAAAACCAAG T7CAAAGCTA TrGCTGGAGA GTCTTCAAGA ATCAGATATA AAATTTGTCA CAACAATGGG AGAAGGACCA AAAAATGATA AACCCCCGTC CCT-rAATAAG CTCGTATTGT AA~rGTAGAA ATGACATTAA TGTACACTGA ACTATGAATA AAAAATAGAA AATGAGGTGC TAAATAT17G GTACAGATTG TAAGTACCT AACAGAGATT TCT7AA FTAA CAT7ATTCCT 'ITATAATTrGA GGGATI=GT GGGGTTATTG GGA'ITGAAC TCTACAGCAT GGGCTAT7AT AGGTTAAAAA TAGTGTTCAG GAGTFCTGG GGAAGAACTA AAGGTAAGAA GAAAAGAGAT G'IMACAGAA GGGATAGAAT TAACAGCTCT GTGAAATAAT 'I=CCCTrAG ACTATGTATA ACTAGTGGAT A IMAAGAAA AATGAATATA AGTAAAATAG ACTTAGCGAT ATATAAATAT CATAACATAC CACAACAGAG CAT7GTCCAC CCCCACAACT TGAAGATGT7 CCATAAGTCC CTCTGGGTGC TCTGACATTT CCATGGAAAT ATCTGCAAAT GAAATACAAA ATrATATfA GATGTATACT CTAAACCAC ACAT'17ATAG CCTTT7GAGGT GGTGGTACA ACTCAA TAATCAGAAT AAAACACATA TGTCTACTAA CCCTGTCTGA GGTAACAGGT TTCTCAGACA TAGATGAAAA ATFEACTI'CAA A TrrACATCA GAACTGATGC ACAG'ITGT =FGTrCTAT 'ITrAT7i=A CGCI=AGTC TCAAGTTGCT AATCGGTACT GCCCTGAATT =ITCTATGG TTrGGTAA'7 ITTrATACCTG CTI=CTGCT GAGCTATTAG ATAAAACTAT TFTAATATI7A CTATGTATAT WO 00/09525 PCTIUS99/1 7712 Let-1 09 56 'TTAAAGT ATTGTTGCTG C'IAATTAAC TA117GATGCT TATATrAAT GTI7ATAGCCT CACTCTI'GAT CATAATGGGT CAATGCCTCA AATACCTAAA AAAAAAAAAA AT1TAGATAGC CAGACACCAG GAAAGAAAAG TAT'11C'fl17 TAATAAAA AGAAATACCT rI=GAGCAA CTGAAATGAC AAAGTCACAA A TTCCTGCA CACCTAAAA TATACTAAT GTAAATGACG AGTTAATGGG TGCAGCACAC CAACATGGCA CATGTATACA TGTGTGACAA ACCTGTATGT TGTGCACATG TACCCTAGAA CTTAAAGTAT AATITAAAA AAAflCTATC TTCCAAAGCA TATCACT7CT CAGGTAGACA CAGTGTI17AT TGCAAAAGAT CTGA ITCAA TAGTAT1CT TCAAGAGTCT CCCCAGAGAC AAAGTCAAGA AGAGGAAATC AGCATATCTG AGAAGAAAGA I1rCAGGATC ACTflT1TG AGGGTCTGAG AAAATGTIA GMITCTATAT TAYIAAAAC CAGAATTGAA ATGGGGTGAT TCCTATCCT'r GCCACCTGCC TCTACAACCC CAAGAG TTC TATCTGAGCA TCTAAACGTC TITAGGCTG AAAGGCTCAC CATGGCTIG CTrGGTCCTr CTCTAGTTCT TCTGCAGCCC ATTGAGCCTC 17GAC=AGC ACAAGGGTCT CAGGTCCT7G CCCAAAGGGA GTGTGCTGTG CTGCAGGTAG ACrGCACTGA ATGTCAACAG AAAGCCrTGC n7=~~CAT TTCrCTAACC CAGTCTCACA TCCTCCTCCT CCTCCC=Tf TCCCTCCCCT TCCTCCTGCA C=CTC=rC CTCTICCCC ACCC=TICC TAGACTGGCC TCTATTGCCT CCCACTGAGA CAAAAATGAA CTGCTGATCA GAAAGTAATG TGACTAGATr CTC-rrCCr TCCCTCC1T CTATCCTCC flCCAFrCTC CTATGCATCT YrCCrrACCC TCCTCCTCCT TCACTCATTG TTGrrGCTGT T==C~CCT CrrC'II=~C CTCCTGCrCC TCTrCTTCTA CTTG~rcrrG 'FrC-rGTI= TG'T7GGTTC TrG FrCTCCT CfCCTCC'Fr CTCTCTCTCC TCCTrCCTCCT TCI=CCAC CACCCTCCCC TATC'TITC ATAAATGCTA AACTAACTr TGGCTACCTG TGGTAAATGG CCCT7GGAAA TrGCAAATAC TACAAATCAA AACTGCAnI7 CAGACATA7 TATGATGT7 GCAAAACTTrC AGTAGAGCTA AGCAGTGGAC T7GACTCGTr TCGG FrCC' CACCTCCGTC T'17CCTTGCT CACCACCTAG TGGACGTCCT TGTTAGTGGC ACI7CCTGAA GTTAACCCCT GAAGAGAGCC CATGcTcTCT AGCI=TCAC CGTGTAGGTI' TGGGAGCCTA CAAGTACCT TAATA FrCTr GGACTATAAA ATGAGATGGT TTrATAAGAC TGCATGTGAA A'F1AGGACCC ATATGATGAA GGACAATAAA AAGGAAGACC CACTGATGTG AGTCAATGAG TCAAATGCAA ATCAGATI7rG CATITAGG AAAATAATAA TAACAACAAC AAAAACTCTG AAGCTCAGCG CCCCATATn7 AT7ATATTGT T-rAATCFIA TAACAGCTCT CTGCTATAGA TATGATTA'Fr ATCCCCA'ITC TAAAGAGTCT CAAAGAGG'Fr AAGAAACAAA TTCAAAAACT AGCGAAAGAC AAGAAATAAC TAAGATCAGA GCAGAACCAT AGGAGGTAGA GACACGAAAA AGCCTITCAAA AAATCAATAA ATCCAGGAGC TGCA=IIGA AAAGATrAAC AAAATAGATG GACCACTAGC TAGACTAATA AGAAAGAAGA ATCAATAGAC ACAATAAAAA ATGGTAAAGG GGATATrACC ACTGATCCCG TAGAAATACA AACTACCATC AGAGATTACT ATAAACATCT 'TTACACAAAT AAACTAGAAA ATCTAGAAGA AATGGATAAA 77CCTGGACA CATACACCCT CCCAAGACTA AACCAGGAAG AAGTCAAATC CCTGAATAGA CTAATAACAA GTTCTGAAAT TAAGGCAGCA ATTAATAGCC TACCAACTAA AAAAAGCCCA GGACCAGATG GATrCACAGC CAAAT7CTAC CAGAGGTACA AAGAGGTGCT GGTACCATTC CTCTGAAAC TATTCCAGAG AATAGAAAAA GAGGAACTCC TCCCTCACTC ATIIATGAG GCCAGCATCA TCCTGATACT AAAACCTGGC AGAGACACAA CAAAAAAAGA AAAT'ITCAGG CCAATATCCC TGATGAACAT CATrGCGAAA ATACTCAATA AAATACGGCA AACTGAATCC AGCAGCACAT CAAAAAGCT7 ATCAACCACA ATCAAGTTGG CICATCCCT GGAATGCAAG GCTGG'TrCAA CATACACAAA TCAATAAACA GAATCCATrA CGTAAACAGA ACCAATCACA AAAACCACGT GATTATCTCA ATAGATGCAG AAAAGGCCTr GGATAAAATT CAACACCCCT TCATGCTAAA AACTCTCAAT AAACTAGGTA TTGATGGAAC GTATCTCAAA ATAATAAGAG CTAMhATGA CAAACCCACA GCCAATAGCA TACTGAATGG GCAAAAACTG AAAGCG F7CC C1TAAAAAC TGGCACAAGA CAAGTATGCC TCTCrCACCA CrCCrGTrCA ACATAGTA T GGAAGT7CTG GCCAGGGCAA TCAGGCAAGA GAAAGAAATA AAGTGTATFC AAATAGAAGA GAGGAAGTCA AATTGTGTCT GTIGCAGAT GACATGA'ITG TATA'IT7AGA AAATCCCAIT GTCTCAGCCC AAAATCTCCT' TAAACTGATC AGCAA=TCA GCAAAGTCTC AGGTTACAAA ATCAATGTGA AAAAATCACA AGAAT7CCT7A TACAGCAATA ATAGACAAAC AGAGAGCCAA ATCATGAGTG AACTCCCAT7 CACGATTGCT ACAAAGAGAA TAAAATACCT AGGAATCCAA CTTACAAGGA ATGTGAAGGA CCTAflCAAG GAGAACTACA AACCACTGCT CAAGGAAATA AGAGAGGACA CAAATGAATG GAAAAACATr CCATGCTCAT GGGTAGGAAG AATCAATATC ATGAAAATGA CCATACTGCC CAAGGTAAT7 TATAGATTCA GTGCTATCCC CATCAAGCTA CTACTGACTIT TICACAGA ATTAGAAAAA AACTACTPA AATFCATAT GGAACCAAAA AAGAGCT7GT ATAGCCAAGA CAATCCTAAG CAAAAAGAAC AAAGCTGGAG GCATCATGCT ACCTGAUTC AAACTATACT ACAAGGCTAT AGTAACCAAA ACAGCATGGT GCTGGTACAA AAACAGATAT ATGGACCAAC GGAACAGAAC AGAGGCATCA GAAATAACAC CACACATCTA CAACCATCTG ATCTIGACA AAGCTGACAA AAAGAAGCAA FI7GGGAAAGG ATI'CCCCATT TAATAAATGA TGTTGGGAAA ACTGGCTAGC CATATGCAGA AAACTGAAAC TGGATCCCTT CCFACACCT TATATAAAAA TITAACTCAAG ATGGATrAAA GACTAAATG GAAGACCTAA AACCATAAAA A'T7CTAGGAG AAAACCTAGG CAATACCAT7 CAGGACGTAG GTATGGGCAA AGACTCATG ACTAAAACAC CAAAAGCAAC AGCAACAAAA GCCAAAA'ITG ACAAATGGGA TCTAATTAAA CTAAAGAGCT TCTGCACAGT AGAAAAAAAA AAACTATCAT CAAAGTGAAC AGGAAACCTA CAGAATGGGA GAAAA'TTM GCAATCTAT7 CACCTGACAA AGGGCTAATA TCCAAAATCT ACAAGAAACT TAAACAAATT TACAAGAAAA AACAAACAAC ACCATCAAAA AGTGAGTGAA GGATATGAAC AGATGCT7CT CAAAAGAAGA AGTMATGCA GTCAACAAAC ATATGAAAAA AAGCTCATCA TCACTGGTCA TTAGAGAAAT GCAAATCAAA ACCACAATGA GATGCCATCT CATGCCAGTT AGAATGGCGA 'I1AT[AAAAA GTCAGGAAAC AACAGATGCT GGAGAGGATG TGGAGAAATA AGAATGCTT T'TACAGTGTT GGTGGAAGTG TAAATrAGTT CAATCATTGT GGAAGACAAT GTGGCGA T7 CTCAAGGATC TATAACTAGA AAAACCA'IM GACCCAGCAA TCCCATTACT GGGTATATAC CCAAAGGATr ATAAATCATT CTACGATAAA GACACATGCA CA=TATG T TATrGAGGCA CTATTCACAA CAGCAAAGAG T7GGAACCAA CCCAAATGCC CACCAATGAT AAACTGGATA AAGATGATGT GGCACATATA CATCATGGAA TACTATACAG CCATAAAAAA GGATGAGTTC ATGTCC'TG CAGGGACATG GATGAAGCTG GAAACCGTCA TTCTCAGCAA ACTAACACTG GAACAGAAAA CCAAACATrA CCCAT7CTCA CTCATAAGTG GGAGTrGAAC AATGAGAACA CATGGACACA GGGAGGGGAA CATCACACAC TGGGGCATGT CAGGGGATGT GGGGCTAGGG GAGGAACAGC ATTAGGAGAA ATACCTAATG TAGATGACAG GTTGATGAAT GCAGCAAACC ACCATGGCAC ATGTATACCT ATGTAACAAA CCTGCACGTr CTGCTCATGT ATCCCAGAAA 'ITAAAGTATA An7~AAAAAA AG'IMAAAAA AAGAAAGTTG CCT-rAGTCAC ATAACTAGTA AGAGACATGG T-FGGGAA'ITT GAACAGAGGC CAATCAGTTC CAAATCCATG CTCTGATCA TTAAGCTGAA =~ATGGCAG GAACT=GGAA GACATGGTAA AATGGGGAAA AACGTGGAGC CAGGGAGACT TGTGAAAGTG CCAGTGCTCC CACTATACCC TGAAAGAAGT ATCTAGACTr AC7TT1CT AAGTCCTCTC CTCTAATrCT CTrCAATCTCT CTCTCrTr CTCTAAGAGA TGGGAATGCT GCTCTGTCAC TCAGGCTAGA GTGCAGTGGT GCGATCATAG CTCATrGCAC TCAAGGAATC CTAGGGTCTA GTGCCCCITC TCCCTCAGCC TCCCATGTAG CTAAGACTAC AGGCACATGC CCCAACCCTC GACTAAT1T TIrAITTI= ATITIGTAG AGACAGGATC TCACTATGTr GCTCAGGCTG TAATFCTGTC TGAAGCT7G TCCAATCAGG CTICAGCCA CACCAATTCC CTGAGACTGC TCTCACCAAG GTCCTACACT TCACTAACAC AAACAGCCTA TT(7CCATCC TCATC~rACT TCACCAGGGA GCTCCTGGTr ITCCrCCTAC TTCACTGGCT A'1TCICTG TATCATGTGT TGA'TTCTCCC TCATCTCCCC AACCTCCAAA CCCTTGGAGT ACTCCAGAGA TCACCGC1T GCTCTCTGT GTCTAACCTC WO 00/09525 PCT/US99/1 7712 tvi-109 57 ACTAAC'FrGG TGGTCCAATT CACACTCTI'G ACT=GAATA CCATTTAAAT GCGAACGAAT TCTAAA FTCT GTACAACCAG AACCATTCTC CTGTAGCCAA ATGCCTACTC AACATCTCCA TCCCCAAACA AMT=AGTTG ITCAATAAGC CTCTCATAfl TI1ACATATCC CAAACTGAAC TrCTGAATI1 CTCCTCCAAT CTGTAGGGCT CTCCCACAG CC'I=CCATC TCAGTGGAT7 ATAACTCCAT CCrCCAG'rr ACTCAGACCA AAACTIGG AGTTAACTGA GACACCTCTC TITIT1T=CA CAAGTCATAT CCAATGTGTC AACAAA=FT GGTAGTGGAA ATATTGCGGG ATITITAAG AAATCAGAGA GACCGATGGG GTT CAGGAGG ATAMTATTA TTTAGGTGCA CTGGCCAAGT CAGAY[AACA TCCAAAGGAC TGAGCCCTGA ACAAAGAG'Fr AAGTTACCTr TTAAGCATTT TGTGGGGTGG GAGAGAGGGG TATCTGTGCA GGGGGAAGCA TACTACAGAA GTGAGAAATA AAGACAGTTA TrCAATTAAT TGAGACATGC ATTACATCAT TTCTTACTP TCAAGAAGAA ACATGTI=G CGACT7GAGT FTATCTGTCT AGTGACCT7G CAGCTGCACA GCTAGAGAAA CAGGGTC'I7C ACAATGCCTG GGAAAGGAGG AGAGGTAAGT CTCACTAGCC ACAGAAAAAC AGGCAGTTAA T1TAAAGG GCTCCAGCTC M~CTC'=C TCAGGGGGAG FrGGGr1TG T7ACATACAA CTGAGTrCC GC117ACACAT TATMA'T CT=AA17C CTGTrCCAAA AGAAGCCAGA TACAAAAGGT TACATGTT1GT CTGATTCCAT UTATATGAAA CATATAGAAG AGGTAAATCC ATAGAGACAG AAAGTAGAT[ AGAGGTTCCC AGGGGCTGAG GAAGAAATGG GGACTAACTG CTTATAGGGT ACAGAGTTI C=CTGATAA AAATAT1T7G GAACTAGATA GACA=T1GT TAGGCCATTC TTGCATrGTT ATAAAGAA17 ACCTGAGACT TGGTAAT7A TAAAGAAAAG ATG'TrAATT GGC0rACACT TCTGCAAGCT TITACAGGAAG CATGGTGCCG ATATCTGCTC AGCTICTGGT AAGGCCTCAG GAAGCT7ACA ATCATGGCAG AAGGTGAAAG GGGAGCAGGC ATATCACATA GCAAAAGCAG GAGCAAGAGA GGGATGTGGG GAGGTGACAG TCACTIIAA ACAGCCAGAT C17GTGAGAA CTCATTCACT ATCATGAAGA CAGTACCAAG AGGATGGTAC TAAATCATTC ATGAGAAACC CCACCCTCAT GATCAAATCA CCTCCCACCA GGCCCCACCT CCAACACTGG GGATTACAAT 'ITGACATGAG ATr7GAGTGA GAACACGGAT CCAAACCATA TCAGAGATGG TGGTTATACA ATGCGATAAA CGTCACTGGA T-rGTACA=T TAAGATGGTr G=FTATG17 GTGTGAACTT CACCrCAATA AAAAAAAATA ITIAATGTAC ATTCAGCCAA AAGAAGATIT GGAATAGGAA AGGTCATGGA GATATAT7AA CAGCCATTG ATGGGTGGTA AGGAAAAGAG TGGT~rATrAG ACTGTITGT GGCCCTCAAA AGGTAGAACT AGATCGAGT GGTGAGCATT ATAAAACCAT CACAAAACCC TGGAGAGAGG ACCCAGTGCT GAAGAACCGT ITGCCTGCCA TGAGACATGA GGGAAGTACC AGTGAATGCC ATTGAAAGCA GCATCCCTGG GTCCAAGGGA TGGTCAAAGG ACCACTACCC AACCCTrCCC TAGCCTACGC CTCCATFTACA GATGACCGCA AGA=TTFr GCTCATGCT GCCAACCAAG GCTGCACTCA CTGCAGYTGC TATCAG'IMA TCATGGGTAA AAGGAATGTG CAGTAGAGAA CTAACTAACT GCCCACCTAC CTCCACAATC CTATCAGGAC AAATCACCAT GGCTCACATT TC=TACA77 TGGCATGTAA GCCCCTCTTA CTGTCTGTCA TCTATCTCCT ACACAGTTCA CCTAAACTGT TCTCTCCTGA CCCAAC=~G ATTTCATCC CAAATG=TC =TGCCATCT CTGGGA'FECC TGTCTrCACC ATCACCAAAC TCCCCTCAAT CTTCCAGM~ CCTGTCAAA CrI=CTCCT ACCTCCrrGC TTTGTCATTA GCCCGACTGC CTCCCTAGGA CATCAC=CC CCTGCAGATC TCTCAAGATG ACAATA FIA TI'CTCCACAC AGCACATACT TCAGGGTTGG AAGGCAGGGG CAATCT7CTC CTTTATAATG AGTGCCTC7T ATATATGIM A'FrCATCTGC CCTCT'rGTAA AACACACACA CACACACACA CAAAGAAGAA ATAAAATAAC TCTGCIC= TGAAGCTrGT GACACTGAGA TAAACCATCT CACTGTCCTC ATTGTAGTGA CCTCTCAACT CCTCATGCAA GAT-GGC1T GGCACCTAGT TCCTGATCTT CUITCCCTG TAAGCACTTC TCATAGTCT7 ACGGGACTTC ACCATCCATG GCACAACCAA TACCACAGCC CAGATCCTCA GCTCTCCAAT GACA=IrCC TCCACTAGAC TTGAGCTACC TCCTCCCTA GGCACAGCCT CAACCTCGAC AACACCTAAG ACTGTACCGT CTCTAAAGTC ACATGTFCAA ACACTTCACT C'=AACCAC TGTCTCCTAT TCT7GCAAGT GTATITGCTCA AGTATCTCAT TGCAATGC= TrTACrA C~rCATTGAA CCTCCAGGCC A'rrAAACATr TCCT1TC TAACCATCAG Gn71CTCCT[ ACTrG ITGT TTGTrA'Tr GTI7T'T= nrrrrrr 'IGAGACAG GGTCTCACTC TG'ITGCCCAG GCTGGAGTGC AGTGGTATGA TCTCGGCTCA CTGCAGCCTC CATCI'CCCTG GFTCAAGTGA TTCTCATGTC TCAGCCTCCC GAGTAGCTGG GACTACAGGT GCATGCCACT ACGCCTGGCT AAGATITGT A7rITTFA GAGAAGGGGT TITGCCATGT TGGCCAAGCT GGTCTCGAAC TCCTAACCTC AGGTGATCCA CCTGCCTCAG CCTCCCAAAG TGC7GAGATr ATAGGCATGA GCCACTATGC CCCACCTGGT 7rCTCCTTAT FrAMTCAAG TCTATGCTGC ACTATTAAAA CTGCCTrGAC AAAAATrATA ATAGTGAGAA AArATGACA GTGAAAGAGA TCTGAAATAA TCAACCCCCA TCTTGCCT' ACCTCCAGA CTGCCCTrAA TAATTCCTGA GCTrGGGCCA AGCTATC'= GGCAGAAA'F[ TAG'ITTATAG TIAAATGAT AATAGCCCY CTCCAAAACT AAACTGCC= TGTAAAACTA ATAAAAGACC ACCAATGAAA GGTTAGGAGG ATGAGAGGAG CCTGAATrCT GCTAAGGTGT AGATGTAAAC AATTACCAAC TGTTA'rCCG GAGGTCACAA GATTGCAAC ATCGCCAA~r ACTCCTGCAG ATAACAGCAC TATCATAGAA TCTGAT7GGC CTI=GAGAT GTCTPTCAG ATTCTTACAT TTCAACTGGT GGCTCTACCT GGACCCATCA ACAAGTCCTG TGGCTCCACC CAGAAGCAGA CT7AACATGC ACAAGGACCA ]TICCACAC CGCTATGAT7 GCATCCCAAC CAATCAGCAG CAACCATrCC TCTGCCTGCC AAATTATCCT TGAAAAATCT TAGCCIrAGA AT1TGGGGG AGGCTGATI1 CAGTAATAAC AAAACCCCGG TCTCCCATI-T GGCTGGCTCT GCATGAATTA AATrCTPCT CTATTGCAGT TCCCATCFrG ATAAATCACC 'T7ATCTGGG CAGCAAACAA AAGGAACCCA 'I1GGACAGTT ACACTGTrGG CAGATATATC TrGCTFCCAA AATrGGATTT 'TG'Tr7AATG AATTTA17CT GTI=C=GA TA'ITACAAC TGTGAATGT7 GTGTCTGAAT TcrC'TIATT TCT7GTTGAA AAGAACTATA TTGC'TACAGC CAGTACATAC AGATGGATAG CTAATTACTC AACACGGGGG GATGTGACCA TCACCGCACT GTGCAAATGA ATGI1'ACCCA T7GTCCACT 7rCCCAAACT ACATAGTGTT ATATGGTATA TGACCCAATC AACGGTGGCA AAGCTCCAGA AATACCACAT AGACATCAGG GACACI=AA ACTAATCAGC CTATAGTCCT I=fCAGTAA 'ITrCCAAACC TGGTrGTGCA TCCAAATCAC TrGGTAACAT TAAAAAAACA AAAAAATATA CACGCAACAT TCGCTCCCAA TCCTACTGAA TCAGAATATr TTGGGT7GGT TCAGGAACAT TCAGGAGTrr 'TCAGGGTCC AAGGT-17ATA TAAmITGAGG TCTCTCTFG AGAAAAGGAA CGTAAAAGCG TC=GC'TT ATAGATCMA CAAAGATGTA YFACCATGTA AACACATrCC TAGGACCCAG GCCCTrGTAA TTrAAAGGTr TATCTAAGTA ATGGGCCCTG AAGC'JAATr 'FrCAT7ATCT TCAGGGCAAA TTACCTGTGG GTTAGGGTFr AGGAATATAT CTCTCTGTGT ATGTGTGTGC ACA'ITAGCAT GTACGCTrGT GTGGA TTM T~fT7IT 'ITrr=~C TUAGACAGAG TCTCGCTCTG TCGCCAGGCT GGAGTGCAGT GGCGTGATCT CTGCTCACTG CAAACTCCGC CTCCCAGGCT CAAGCGA'TC -VrCTGCCTCA GCCTCT-rGAG TAGCTGGGAC TATAGGCACG CACCACTATG CCCAGCTAAT rr=GTATrT 'FrAGTAGAGT TGGGGn7~CG CCATGITrGGC CAGGATGGTC TTGATCrCT-' GACCTCGTGA TCCACCCGCC TCCACCTCCC AAAGTGCTGG GAITACAGGC GTGAGTCACC ATGCCCAGCA CTGTGTGGA TGTITAAGC TCCCAGGTGA GTGAATACAA AACTAGATCT 'TCCCTTCTG TAG CATCTGT ACTGT,1rACT CTATGCATCT CAATA TIT TCFITAGTA TC=CT VrCTCTCr]7A TrACMCCTC TFGTGCTA Fr 'IACACCTC CTITITAAA AAATTITC CCT1TA7rT CTATTGACCT 'FrAGCCCTCA CAATGATTCC TACAAGCCCC A'T7rGTAA ATGGGGATTG AAATAATTGC TGGACITTG AGAGATAGAT ATA'rTAAA'Fr GCAAACTGGC AGTAGTGGGG GCAGTrGATA CATAACTAGG =IIAAAGTC TAGCCIT7CTG AGACCACTCA FrCCAMFGT GAAAAGTGAT TCTA=TT A'rrATGAGCC AAAATATGCA TrCATTCACC CATGCATTGA 'TrAT7CA'T CAATAAATAT TTG7FGGATG TCCACTCTGT ATCAGGAATG TGCTAGGTFrC TGGGAATACA WO 00/09525 PCTIUS99/1 7712 EPI-109 58 GCAATGAACA AGGTAA I= TCCCTACCCC TAAGGAACTr AGAGTMAGT GGGGAAGACA GACATTAAAC AAACAATFGT GCAAGTAATA ATCTATAA~r A=fATrACA ATTAAAGGAA GGAAGAGACA TATGGATTAT GAGGGCAFA AAGAGGAGAC CTAGTGTAAG TAGCCAGTTrC TCGTGAAGGG ACATGTAT7A GTrGGAGTTC TCCAGAGAAA CAGAACCAAT GGTGTGTGTG TGTGTGTGTG CGTGTGTGCG TGTGTGTG7T GGGGTGTGGG GGTGTGGTAT rT=lATAGA AATTGTCTCA CACAATrATG GAAGCTGAGA AGTCCCATGG CCTGCTGTCT ACGAGCTGAG AACCAGGAAA GCCAGTGGAA TA=TCAAAG TCdAAAGGCC CTGGAACCAA GAGTGCCAGT GTTGGAAGGC AGGAGAAGAT GGGTGTCCCA GC'TrAAAAAG ACAGTGAATr CACTC1TTT GCTCTACATA GGGCCTCAAT GGGTrGGATC ATGGCCACCC ACATTGGTGA AGGCAATCCT C'IAGTCTAC CAA TAAATA CTAATCrCTr TGGAAATACT CTCACAGACA CACTGAGAAA TAATGTITA TCAGGGTGAT AGAAATCITC TGGAG17AAA CAATGGTGAT AGCTGTACAA TCACATACAT 1TrAAAGGG TGCGTITAT GGAAAGTGAG TITATCTAA ATAAAATITC TAAGAAAGAG ACTAACACA GAGATAAACA TAAGCACA7T TATTGTCAAC CI=ATAGTG FI'ATGTCAAA TAGGTCTGAC ATAAGCJTAA ATAAATATAT ACITAAAAA TFATAAAATA TITAAGTTA TAAT17AAAA TTCTCAATAA AACTCAAACA CAAACCACAC TGGTA=rCA CACAGCTAAT TrCTAATGCA GTFI1ACATAA ATA'I=ACAA CACTrAAACA A ITCAAAGA AAATAACACT GTA ITCCATA CATAGCCTGA TCACAGTAGT TGTTCTCTCT TA'TrCCCAG AGTTMCTG CCCC1TAAA AGAACCTCTG CTGITCTGAT CCTTATCACA TCTCTGTIT GACTGTrGGC 'ITrGT-rGTTG CCAGTGF1CA GCCAGAACTT CTCTGAAACT 'IrmTCAA CACATG~1rAA GT7AATGGAA GTGTAGGAGA G=ITGAT7C TCACACTCCT CAAGGCTAGA GCAGCTIGG CAATlACTGA CTGAGAA Ir TTCA F7GCCA GTGATCAACT GAAAACTGGA GATrC=1IG GAATrGTrAA ATCTGCI1rAT AAATAAACAT AAATGC77GC TCACACAGGC ATI7CCTCTCT TCCAGAGCAC CCTAACATAC AGAAGAAAAC AAATAGGGAA TAACTATTAG ACATCTrCAT TCGT-rAAAAA TCTACCAGAT GACTC'fT]A CATGGTGAGT T7CTAITrGTG AA1TFAAAAT CTTCCATAAT ATACAAGAAT TATGTI7ACA TATCATATCT GACAAACATC MIIGTAGGAA TGCAAAGCAC ATCCATCIT CTGTATrCT7 TTCCAACAAA GACATTCATA AAAT7ATACC TTGTGTGfl TGCA=IIATG CTITATTAG rrCAAAACGT TTGGCCTCAT GGAAGTITF CATCGTGGAA ACCACATATT TCTGAAAAAA TATCTGACAA TATACAAACC 'FrCCAT7CAG 7II=ACTCT CCAATTCTAC CATGTITCA AAAAACAACT GTAGTAAAAA CACTCAGAAC TTT7AT7CTGG TFTAACATCAT GC=TGCTAG GGGACAATAG n7~CCC'I= TGAAATAAAT TrAAAACAGA TGTAACATAA 'I1rGT7AATA AACAATGAGG GGGTAATCTA GAATAAGTAA C'T=ACCAT ATCATAGTTG ACAGCA'TTFA CAAG'TTI AAGTCCCTAC CACACTTGTA TTGAATGAAG AAGTATGGAA GATrATAATA TATTCAATGC AAGTAAAAAT ATCACAATCC 'FAAGAACTC 'TAAGAAGC ACTGAATCCC ATAGGGATGA AAGTGATTAA ATTGTGCATA GTAACCCTCG CACAGAGCAT TCAGTAGGAT 'FFGCACCATrT AACAACCCTC CATGCA'I=G CCTGTGGGCA TTCAACATCT GTCATflT1 TAAGTTATAA TATflIAGT CATTrITIC CrCTAAACTC TGGATAA11A ITrATrCATrC TTATGACAGC AACTGTGTAA TCAGCTGTCG AAACACTGTG AAGGGCAAAA GAAAGAAAGC CACAAAATAT TGTGM~CTG TGCCAAGA Tr TFACAGCGAG CAAGGGAGAG TrAGAAAAGG AAflCGAGA TI1CAGAGTC 'FrGGTCrC'IT CACCTTGCT TGGAAGAAAA TATCC'=CC CTTCATTAGC CAACAC 7rGATCCTGA GAGTAGGAAA GGGAACACTG AGTC]TICA GTTGAAGGCC GTCCI1TGCCT GCTGGA=IT GATCTATTGA AGTGGTGATG GGTG'rrGCGG 71TTCAGCCAT AAAGGCATCT GGCATAGTAG GCAAGAAGGG CCAGAGACCC GAGGAGAGTF ATCTGTCTCT GTrAACTTCA GTGTATCCCT CTAGTrCCCC AGATGCACCT GTITCTGTAA ATATAAACAT GCATGTCATC AGAACACT7A ATATrCTGCA TACTGATCAT GACAACAAAA TGTACCTrCT AACACAGACA CTCTCACTAG GATAGACCAT GTAGGAACAT CGAATrCTAT TCAGTrAGGA CAGTGATGAT GTCTACATAT TATACCTCTG TCAAAACCTA CAGAATATAC AACACAGCAC AGAGTGAATT CrAATGTAGC CTGTGGACAT TAATGAATAA TAATGTATCA ATAT'TGGCCC ATCAG'ITGTA ACACTATAT AAGATGTrAA TAACAGGGGG AAT7GAAGGG GTGGTGGGGA GATATGTTGG AACT='~GT GCT=CTGCT CAA'T]TCT GTAAACT7AA AACCGCACAC ACAAAAAAAG 'ITATI=AAT '-MTAAAAA GTATTCAGAG GGACTTGACC YTCCAAATT CrCTCAAAGC AGGTCGGAGT AGTTAAGAAC ACAAA1TFA GAACCAGACT GCCAGAGI7r GAATCCTGGC TACACCAMT ACTAG='TG AGAITCAGA CAATTAC'Fr AAC'FrCTCTG TCTCATITC TTCATCTGTG TGATAAGAAA TAAAGTAACA GGCCAGGCCC AGTGGCTCAC GCCTGTAATC CCAGCAC1T GAGAGGCCAA GGCGGGTGGA TCAGGAG FrC AAGATCAGCC TGGCCAACAT GACGAAAAAA TACAAAATCT CTACTAAAAA TACAAAAATT AGCTGGGTGT GGTGGCAGGC ACCTGTAATC CCAGCTACTC AGGAGGCTGA GGCAGGAGAA TGC=GAAC GCAGGAGGTG GAGGTTGCAG TGAGCCAAGA TCATGCCACT GCACTCCAGT CTAGGCAACA GAATGAGACT CCATCTCAAA A'ITAAAAAAA AAAAAAGTAA AAAGAAAAGA TAAGAAATAT AGTACCAGCC CCTATCTCAG AGU7CCTAGC TrAGAAAAAT TCCCAGAATA TAATAAGTGC AATGTAAGGG TCAGCTATCT TCATFATrAT TATCTATCAT AAATGAAATF ACACAATAAA GCTAGATCCG T7=TCCT CTCCTTCTAC AAAAAATAAA GCAACTI7rCC AGAACAATAC CCAGGTGATG A'IMCTCCCC TGCTCCCTCC CTAAGATATr GGCAAG'ITG GAGGG~rCAA GGAGAAACAG AGCATGTAGA GAAGATACCT CTCTCATAAC CA'ITGTGAT TrACAAGTCT TACCTGATFC TT=GAACTr AAAGGATGTA AGAAGGCIT TGGTAGCTrC CATCrGATrC AAGG='TGG CAGCTGCTGT GGAATACATG AGAACACTAG GTAAAGCACT GTC-VCCAAC ATGAAGAGAG AAAAATATGT GGAATGTTCA ATGGCATGCT rGTATAAGA ATGCAACrrA CCTGGCAGGA ACAAAMICT TrGCTGCAAA AGAAAAGACA AACAACCATr AATTCAGA~T AAATGAC'= TAAGGATATA 'TrAAATCCAG ATACAATATG ACTTAATTCA TCAAGTG ITG CAAACTCGAT GCTTCAGGGC CTCTGTAATA ATCAGAGCAC AAGCATGGCT CTGTGGCATC TAGGGTAAAA TGCAAAGTGC ACAGCCATCC AAAGGGCATA GCAGC17CCT AATGCCAGCA AATAGCTACG GGGTCATCT GCCCAATTCA GCTCCCAAT7 TTCATGAGA AGTCCAAAGT C=AA'IMAA ATGTGAGATr TCCTAT1TG TAAACGTCAG AACTrAACrC AAAAATGTTT TAAGTACTC7 TAAACATGTA AGCCAAACAA ACCATGAGTG TAGTCAGATG TGCTTCCATA TTCCTTATGA GAGACTCrCA AA'IMAAGCC TGTACTCCAA ATAAATCTCC 7rAGGAAGAA TITATCCAT '1TCCTTAGA GTGCTCATCA TGGCAGITFCC ATTGCACAAT TCCGGGAGGC ATCATATAAT TCAACATGAA TAGCACCCCC TGGAGTTGTA CAATATrAGG CACGACTAAC A7FITATTT CCTGAAACAC TT7CCCACACT GAGT7GTACT ACTAACTC TT FC~rAATAC 7TCTGCTTAA ITFATACTGCA =1TATCCAG ATrTCTAATT1A TITGMIAAAT CAGTAAGCAA GACCATGACT TATCAATGAG AAAGAAATGT ATITCAAAA ACATI=GA AGTACAUrCA TAAAC11TCCT CACC'=CCG TAAGCA'TrTC CGAAGCCAGA GGAGAAATGG TGCTAATGTC AGGAGGGAGA GTCCAGCAGC AGAAAGTCCA GCTACCAAGG GAATGTrGGA CTCAGTGGGA GCTAAGGAAG TAAGAGACGA AGAAAGGTCA TGAGGAAGAA TTGATGTrAA AGTCTCTCCG TCCTGTCCCT 'ITGGCCTIT TTCTGTACAT TCATTACTAG GAGCAGAAGA GCTATCTAGT 'F[AATACAAG AAGCAGAGAT GTGGCATTAC AGGCC=rGA GATCTGCTCC AAGCCACCIT TGAAGCTATT TCCACCATrG GCAGGCAGAA CTCTAACTTG CCAAGCTCGT TCACAATACC ACACCACACC 'I1GGTTAATA AACACTGCAC TFTGCFGCTC TCT~rGcTcC ACTCCCTC7 GTI=CCAT7 TCCCCITCT CCTCrCCTCT CTCTGTCTCC 'ITTCCAGT TGTCAGAAT-f CTACCCT CATCAACATG CAAC17CTGT 'TI=CTCTA TCCCCATACA ACTTAATATT CACAACTTGT CAACCTGGGC GAAC'=CTG G'IMGGATAT AATGAATAGT TGA~rACTGT AACAAGATAG CTCCCCC'= TTCTITAA TCACCAGACA ACCACCATCA ATCAATGCAT CACCTrCACA GGTAGGTAGC AGGCCAGACC AGTGTCCTGT GGCTCCACAT GTCCGAGCTG CAGAGCCATr WO 00/09525 PCT/US99/17712 EPI-109 59 GAGCGTCCAT CCTTCAGGAC AGGCGAACTT GCACACAGTG CCAAACACGG GCTCCCCACT GCAGCTCATG TTGATCTTTC CCGGAACTGC CAGGCTTGAA CATTTTACCA CTGCAAATGT TAGGTACACA GGCAGAGTTT CAGAAAAATC TACTGGAAAA CTTCCAAAAC TTGCTrAAAA GTCAACAATG AATGTAAAGT GTAAGCGCTA CTrAGTTTTC AGCATGTAGG AAATTAGGAC CAAACCCCTT TGGGGCAATC TAGGTTCAGA AAC'TATGA AGTATTTGAC CTGTACCCTA AAAAAGTCTG CACTCAATTC TACCTTGGCA GGAAGGAACC TCTTCTGTCC ATTGTCCCTG AGATGTGCAC TCAAGTrGAG TTGATCCATG TAArCAAAT CCCTCCTCAC AGCTGAAGGC ACAAGAGGAC TTGTAGGTGA ATrCTCCAAT AGGGGAATGA GCACACCTCA CCAAACCCTT CGGGGGCTGG TGGACAGCAT CGCATCTCAC AGCTGGAACA CACGAGAGAG CACTAGAA GTTTGTTTGC ATCTCCAGCA ATACGT'TTCC CAAGGTAACC AAGTTCCCAA GCTCTTCAAT AGTTCTIT11 ATCTTAAAAT AAAATAAAAA CAAAGACTGT ACCTTCACAT GTGGGCTTCT CGTTGTCCCA CTCCCCTGTG GGGCCACATT GGAGCCTIT GGATCCCTTC AACACAAAAC CCTGCTCACA GGAGAACTCA CAGCTGGACC CATAACGGAA ACTGCCAGAA GCACTAGGAA GACAATTCAT GTAGCCTCGC TCGGGGTTGG ACAAGGCTGT GCACTGGAAA GCTGAGACAT CAAAATGATG GTCAGAAAAT ATTGCAGTGG AACTAGAGAG TACTTGGCGT TTGTTGAGTG AACCCAGTTC ATTCAAGCAA CACTTGGAGA ACTGAAGATT CITTATAATr CCCTGGACAA ATGGGAAGAT GGCTGTGTTT TCTTGAATT TCAGCCCCCT CACTGATCAT GGCACTAATT AAAAGACTAA TTAATCAGAA CATTAGTTCC TGAGCACTGT TCTTCTAACA CACAAAATAA ATTATGGTCC AAGGAAAGAT TTCACGCAGT CTGAGGACAA CATATGGGTC ATGGATGT ATAGATGGTG CCAAAAAGAA AGAAAAGAAA GCACCCCTAT AAAATGTC TGT=TTGCAG TTGGTTITr GTGTTATGTT TTGCTACTGG AAATCATTCT GTGCTGGCTT TGGCTAGGAC AAGGCCAGTG CCTGATAGTA AAAACTGCTT GTTCAATA TCCTTGCTCT CACITAAAG TGAATTAAAA TTTACTGCTT ATATATGCAT CAATACTATC TCTGTAGCTG ACACCATGCT TGAAACAGTC TCATCACTGC TAATTATGAG CCATTTCAGA AGACAGGTGT GATGAGAGTT TTACATTCAA ATCATGTTCT CATTATrCTG CITICCGAAT TTCTAATAT GATTCCTTA GATTAAGAAT TCTGTCTATT CCATGCTAAT GTCTACAAAG TITTATCAGC ACATCACAGT TAAAAAAAAA CAGCAAAGAA TrCATrCTTA ACACATATGA TCCTCCCT GGCCAAACAT TAGTITCIT1 AAATGAATCT CAAAGATACG AGGGTTGCTC ATCAAATCTG AT17CTATAG TTAAAGTGGG TATTGGTTTT 1T1liTCACT GTCCAAGT GAAGATGGTT GTTCTTTAAG AAAGTATAAA TCGAAGGATC TCAAGCTTAC CTTCACAAAC TGGGATTTGC TGTGTCCACT GCCCTTGAGT GGTGCATTCA ACCTGGGCTG GTCCCTGCAA CATGAAGCCT TCCTCACAGG TGAAGTTGCA GGATGA'TTTG AAGGTGAACT CTCCAGCAGG GGAATGGCTG CACCTCACAG AGCCATTCTG AGGCTGGCGG ACGGCCCTGC ATGTCACAGC TGTAACAAAT ATACGCATTG ATATTAGCAC GGCCTAGAAT TAGCTTGCCC ATTTCCAGTA TGGGTTGAGA GAAAGAATGT TCACAGTAAG TCTCCATGTG GAACAACTCT ACCTTTACAC GTTGGCTTCT CGTTGTCCCA ATTCCCAGAT GAGGTACACT GAAGGCTCTG GGCTCCCATT AGTTCAAATC CTTCTTCACA GTCAAATGTA CAGGTTGTGT TCCATGGGAA GCTTCCAGGG ITTGGAAAC ATTCCACGAA CCCATTGGCT GGATTIGTCA CAGCATCACA CTCAACCACT GAGGATTTA AAGAGCACCA TGAATTAC AGAAGAATGA TCTITTCACT TCCTATGAG CTGGGTGCCT AACAGAGTGA GGAAGCTGCC TTCAAAGGGT AGATCCCAAA GTCCTATGTC AATTCTTAGG GACATGCACA GCCAGAATAA AAGCITAT TCTrTICAT GGATATTmTA TCLITCTGA 'TTCCACITT GCCTATGCTG AGTGGTCTCT AATCTATGTT ATCATTTACG TGAGGTAAAA ATTT7AAAAAA AATAGATTCC AGATrAGGAG TTATGACTAG TACTGACATA CGTAGGCTAT TCATTTATT TAGCCCATCA GAGCCTGAAG AACTGATIT TCTlTFTG GCCTCTGGTT CAGAAAGATA AAATTAAGAG AGAAAAAGAG ATACTAAGAC TGCTrGACTA TCATGGTCTT AAGTTAGTCC CATGGCTTGG AAAAGTTAAA CAGGGAAACA AGATGAGAAA TCCATTGAGA TTTCTAGAGC TTTATTGTT TATGGTCTCC CTTACAAATC ACCAGAGCCT CAGAAACACC CATTTCAAGC ATAGAATAAA AAAACCTCTC TCAACCCAAG CAGGTACTGG GTrGGCAATA TACATTGGCT GAGAGAACAA ATTGTATTAA AAACAAAAAC AAAAAAAAAA CTTTCCCTGA AGTITTGAAA ATGTAAGTTG AATCAAAAAA CAGAAGCAAT GAGGGATGAG TTACAGAACG TTCTGTGCAT TCTCAGAGGG ATTTACCATT GCAGGCTGGA ATAGGAGCAC TCCATTCTCC AGAGGACATA CACTGCATGG TCTCCATGCT GCTTGGCAGG TAACCCCTAT CACAGCTGAT AGAGCAGGAA GAATTGTAGC TGAAGTTCC CAGTGGGTGA CTGCAAACCA GGCTTCCATG CTCAGGGGAT TCCAGGGCTG TACAGTTCAC AACTGAAAAA GAAACCCAAA TCAGTTCTGC TCATCTCTCA CCTTAACAG ATAAGAACAC TGGAAACTAG AACTACAGTT TGGTT=TT TITITITAGT TTAAAAAT ATAAAATTTC TAATGGAATT TGTAAAATTG ACTGTAATTC TACCCCTITI CTI1rATTCA AGAAAATGCT GATCCATAAC AACAACAACA AAAAAGCAGT GATGACAACC ATAAAAAAGA AATATTGAGT GATATGGGGA GAGTAGTGTA ATTGTGTT7A CCTCAAAACT GTTCAAATTA TATGAACAAA CACAGCAAAC TTAGGTACCA CAACAAATTT CTTGTTACTT TTCTCACAAC TGCTAAAAAT ACTACAGTAA GCTTCCAACC AGGATGAGAA CCATTCACAA AGCTATATTT CAAATTTAAG TACTAGAATA CATTACAAAT ITTAAAACCC TAATGCTGCA CTGTCTACTA TAGTAGCCAC TATCTGTGTG GCTACTCAAA TTrAAACTTG AATTCGTTGA AATCAAATAA CAITAAAAT TCAGTTCCTC AGTGTCACCA GCCACATTTC AAGTACTCAA TAACCACATG TGGCTCATAG GTACACACTG GAAAACACAG CTATGGAACA TTTCCATTAT CACAAAAGCT CTACTGCACA ACGCTGTGCT AAGGAATCTT GGAGAGAAGC TCATCTAACT CTCTTAATGT ACAAATTTAG GAACTGAGAC CTCATTTCAT TCAAGTGACT TGCTCCATGC TACACGGCTA GTCATTACAG AGCCAGAGGC CAGAGCATGA ACCAAGATAC CCTGGACTCT GTAACTCACT CATTCTACT GCAACGTCTT GTTACCACCT AGATGAGGTG AGTACATGTT CCTCGCAGGG ACACAGAATT ACAGTTTATT GAATGTGTCC TGTGTGCCAG GCACCATGTA ACCATGAGCC TATGAAGTTC ACACTATTAT TATCCTCATT TTACAATGAG AAAACTGACA TAGAGAGTTA AACTATCTTG TCAAGGTGCC AAAATAAATA ACTGGTGAAT CTAGGACTCA AACCCAGCAG GGTCTGACTT CATAGTCTCA GCTCACGATC ACCATATGAC ACCATCTGCA CCAGGGAAGG GAAGGCATGC AGACCTGACT CTAATGCCAG CTAGGACGTG AGATGGTGCT ACCATCTCAA GTGAAGAAAG AGGCAAGAAC CAGACTTACT TTGCTCACAC TTGAGTCCAC TGAAGCCAGG GTCACACTTG CAAGTGTAAT TATTGATGGT CTCTACACAT TCACCGTGGC CACTGCAGGA TGTATTGGTA CAGGCAGCTA CGGAAAATAC AAAGCATGAT GAGGAGGACT ATTACTGTGC TrATACTGAG TGCCTTTGAT TAGAATCA ACAGTGTGCA ACAGAGACAT CAGCAGTCCT ACAGAGTGCC ATAGACTTTA ACTGAAGTGT TTTACAAAGT TCCAAATCTG AGTCAGGC CCACCTATCC TAAACCTTGA TGCTAATGTA TAGCTGTGGC TGGCACCTAC CGTAGAAAAT TrACTTCTTC ACAAACTCTG AAGACAGTrC CCCTACCACA AATAAACAAG TAATTAAAAT ATGTATrGTG TGTGTGCATT TTTATATGTA AAGAACTACA TATTTGCCTA CAGTATTTAT ATATATTA TATATATACA TACACACATA TATGTGTGTA TATGTGTGTA TGTATATATA TAAAATGTAT ATAAATGCTG TAGGCTATAT ATATATACAC ACACACATAT ATGTGTGTGT GTATATATGT GTGTGTGTGT ATATATATAC ATATCCACAT ATrCTTGCCC ACAT7CACAC AAAACAGCAA AAGAGAGAAA CTAGCAGT TAAACAGAAT CITIGGAAC ATAAAATGAC CACAATAGAG AGCAGT1111 GCATGCTGTA AATTGCCAA GATGCCCACA CACTGAAACT ACCTCCCACT GCTGCCGCAA ACTCCCTACC TGTGTAGCAT AGGGCAAGCT TCTTCTTGCT GCACCTCTCA TCATTCCACA TGCCCACATC 7icCTCTC TrGATGTAGA TCTCCACGCA GTCCTCATCT TTITGCCTAT TGTTGGGTTC ACCTGGAGCC CAGTTCTTGG CTTCTTCTGT CAGAGG1TC TGGGTTCCTA CCCAGACCCA CACAT7GTTG ACTTCTGA TTCCAATCCA GTAATAACTT GGTGAATAGC TCAATATGGA GTAGGTAC TCAATCTCTT CTTTG=FTTG AATTGCAACC AGGTGTGTGT ACC=TTGCTG ACAATAAGCA CTGGCCTCAT WO 00/09525 PCT/US99/1 7712 EPI-109 60 CATAAGTCAT AGCTrCCGTG GAGGTGT-rGT AAGACCAGGC TCCACTCTCT T-rAATGAGAA GCACTAGTGG GAGAAAAAGA AAAGAAATGG TAGAGTITGG TACTGTrGTG GYFFTAACTCT GACAACTGTG CTIT1TTG T=TAT=FF GGCAATGTT7 GTGACATGGC CCAGACTIT CTCATCITI CAAAAGTAAG AAGTACGTAT GAAGAAACAG CGAC FFKFTG MFATCTCTT T7GTGACTGC CACCCACTAG GTAC=~ATC CACACTCACT CACAACATTA TAGTATACCC A=T1GTAGT AGAATAATAA TCAGAATAAC TAAGCThrAT TGAGCACTA GTATGCACCA AGAAGCACTG TATGAGGTAC MF1CCATGAA CCATGCTATT GAATCCTCAC AATGCATCTG GGAAATAGGT CAflATGATC CACA=WAC A=~AAGGAA AGGGAGACAC CAAGAGGTAA AGTAAATGAC CCCAAGCCCA GGGAAGAACA CATrGCAGGT AGAGGTCAAG GATGCTGCCA GATATCCTGT GCAGGACAGC CCCAGACAAG CAAGGATAT7 TCAGTCTGAA ATATCTATAG TGCGAGAATG AGAAATCITrG GTCTAATGGC ACTGACTTAC CCAAAGTGAG AGCTGAGAGA AACTGTGAAG CAATCATGAC 'FCAAGAGT7 C=r~CACCC AAAGGTrrAG GCTrGAAATA CTFCCTGGG GAGATAAAAC ACAAAATGAA 7rAAAGAAGG AAATCGTGGG TAGCTAGflA CAT7ATTCTA CCATGATGTT TAAGGCAGCA TCCTAAGATT TTGGGCAAAG GACACTAGTG CAATAATCTr TATI1CAGAG TTTAATCAAA TAAATAAACA AAWIAAGA CI=CATTAT TTAGGTCAAA GAGAAAAGAC AGG=IrAGC TACAATACAA TAAGAGC17G TACAGATGTG GT1TAT-rA GAAGGC=rr TGCATATCTG TG=ITCATGG CCCGAGGCTG CCCT-rATAAA GCGT7CTGCA CTTACCGTI TGGGAAGCAG TF7GflCAAAC ACAGGATCTC TCAGGTGGGT ATCACTGCTG CCTCITGTCTC AGGTCAGTAT AGGAG=IrG ATGTGAAGTC AGCCAAGAAC AGCTGAACAC TACT7CGGCT GAGGCCC'TI TATAGGAGGG ATTGCTTCCT GTGAATAATA GGAGGATATT GTCCACATCC AGTAAAGAGG AAATCCCCAA TGGCATCCAA AAAC=rCCC GGGAATATCC ACGATGCI1TA AAATTACAAT GATGTCAGAA ACTCTrGTCTC TTGAAGCTAC TTCACCT=G TCCATGCC~r TATATCGTAT ATGCAATIT ATTAATATGA CAAAAATGCA TGAFITTAA T7ATAATAAC ATAAAGTCTA TGTCTTAAA AAc3TrGTAAA ACTIGCTTG TTAGTAGTGT CTCTCATGTA GTrGTGGTAG TAAT7AGAAT TI1CAGAAACA GAAGGAAACC AAGAATAGGT TrGTCATCCA TAGTCTACTA CCrrCAAT~r CrCATTCATA GCTGTGGATA ACCAATCACT ACTCATIT TCTTCCTIT TCACCTGCCA A'ITCAACATA nI7AACATGC ACTGTCTCAC AGAGGAATGA CTCACAAGGT AGATATITAAT C1CAGA'IT TGCACGGCAG TTATGCCTAA ATITAAAATAT TATCTAAAAA TAATATCTAA CACTCAAATG GTTAAAATAA TGCCTrArr TAAAAAAAGA AAAATGGGAA ATAGATA'FTr ACATCTGGGA AAGT~rCATG GMT~r'rCAG TGAAAAAAAT AAAAAGGAGG CCAGGCACAG TGGCTCACGC CTGTAATCCC ACCACTPGG GAGGCCGAGG CAGGCGGATC ACCTGAGGCC GGGAG'TTCAA GACCAGCCTG ACCAACATGG AGAAACGCCA TCTCTACTAA AAATACAAAA TT1AGCTGGGC ATGGTGGCGC ATGCCTGTAA TCCCAGCTAC TCGGGAGGCT GAGGCAGGAG AATCGCTrGA ACCCGGGAAG TGGAGG1TGC AGTGAGCCAA GATCACGCCA GTGCACTCCA GCCTGGGAAA CGAGTGAAAC TCTGTCTTAA AAAAAAAAAA AAAAAAAGAA AAGAAAAGAA AAAAAATAAA ACGGAAAACT ATATATATAT ATTTAAT7GG TCAAAA=I~ GM~AAAATTr =~GAAATGT TAATGTGCAA AGAATAAAAA 'FrCTTCCACA ATGTFrAACAG TGACTAACTC TGGATGGCAG GATTGGGAT AA TflATA TCCT7CATTA TTA=r~CAG GATF1AAAG 'FI-f-TICAA 'ITCCCITF 71rCACC1T ATAGTAACAA GAATACAGTr TAAAGAAACT TGTCTCTAGG CCAGGCATGA TGGCTCATGC CTGTAATCCC AGCACTIGG GAGGCTGAGG TGGGTGGATC ACcTGAGGTC AGGAGTTCCA GACCAGCGTG GCCAATATGG TGAAACCCTG TCTCTACTAA AAATACAAAA A7AGCCGGG GTGTAGTGGC GCATGCCTGT AATCCCAGCT ACTGGGGAGC CTGATGCAAG AGAATCGCT-r GAACCCAGGA GGCAGAGG'Fr GCAGTGAGCT GAAATCACAC CAT7GCACTC CAGCCTGGGC GACAGAGCAA GACTrCCATCT CAAAAAAAAA GAAAAAAAGA AAAAGAAAAG AAAAGAAATT TG1TrCCAAA TGCAACAGAA GGAGATGTAT GTGGTATCCT ATATTCCTGC T=TCATTT GACATT1CT7 CTGGGTGA17 GTATACA'TC CCCATCTCTG CATCT7ACCC TATCTAAATG ATGGTAACAG TAAATGGGGA TCATI=AAT TTCCATAT7C TGTAGGTIT CAGAGCTCAA GTCAAGCTAA TATCTATAT CTACAGCCI TCAAAATAGG AGGTCTATCT AAAAATGTAC TGTCAGCAGA CCTGAACGAG TAGTGGTAAA AGCCTCGT7 TrTC=TAC 7TGTrAGCAC TGGTCTICT GTGT-rCATAA AGATGTCAAG ACCCAAAAAA AAAACAAGAA AAGAGAAGAA AAATTCCAAA AAAGACAACT GATlAGAAAA AAATAACTA ATT1AACGAAT T71AAT1TCAAC CCCTATCAAA AAGCATAGAA 'ITAITCCCT CCACCITACC ACTCTCTTAC ATGATCCAGA TACTGACATr ATTCCAATTC TTTATCCCAC =~ACT7AGC TCAATGTGGT TGTrTGC-1rCA ATAAAT7CAG AAGAGTAATC ACTCATATAG TG=TATrA GA=IAGGG CAGAATGTCA AG~FIGGG'TA ATACAT7ATC TGTATGTA7T 'FFAT1TIAA TAAAGTATGA ATACATAATC TGCTATF= AAAAAGCATG GTCAAATGTA TAGAGTAGCC AAAT=~AAA AAACAATIT7A T=7CGATAT CAATAAAGTA CCTAATAATT ATATTGCTAA TAGAAATFTAG TCGTTAACAT CCCTAGATAA CTAACT=AT TArrGCGAAT =IICATAAC TAAG'IMATA G'IMATCTCT TCCCC3ITT AAAATTAG11T CAAAGATATC TAAAAATAGC CCCAGTGGTG ATGAAGITIC TATFIACT7 ACATATATAT GTCCTGGACC CCCAATTATA ATCTCTAACA TITATTGAGT GC17ACTATG TGCCAGGCCA TAT7CTGAGC A'ITI7rGTATG rrCACCTA'IT GATrAT7CAA TCCGTACAAC AGCCTATGAA ATAGGTACTC CTAYEATCCC CATITIACAG ATGAGGAAAT TGAGAATCTG GGGAT=TAT CTCATrCAAA AGCACAGAGC TAAGGGTrGA AACCAGGCAG ITGATATCCA GAGCCCACTC C=TACCTGC TACTCCAAAC CATGA'IMCT M~GT7GTTA TGCCCCGAGA 'FFCCTrGTTC TACCCAAGT-r TCCTGTACTC TrC=GCCCT CTrCTTCCTG AGACATCCT7 GACCATCACA GCTCTCCACT GAGATAACTG TGTCCTGGGT TCTGAGACAT GGGGGCTGGA AGGGACCCCA GGGACAGTGA GCAGTAGGGA GAGGATGCAG TGAGAACAGA CCCTGGATCC CCGGTGCATA GGCAGGGAGA AAGTGGACAA AGGAAAAAAC AAGCAAGGCA GGTGGAGCCA TGCCTAGGTA AAGTTGATCC CTAAGCCACA GTTCCCAGAA GT7CCTGATT CAAAAGCAAA 1TICTCTAA GGTCAAAGGG CAAACTGATl ATTCTAAA'Fr CTAAACTGAT TAF=CTAAA TrGAGAAAGC TCAGGGAGA GATCCCAATA TTCGAAGGAT AAGAGAAATG AGGAGTGGAA GAGATAGGTG AGTAACAGTA ACTIAAATGT AGACTATATA TAATATATAA TATATGTAGA GTATATATAT ATAATTACAA TATA'ITATAT ATGTGGAATA TATATATrAT TTATATATAT rrATATATTT TATATATATA GATAITITA TAFITATAT ATAAATATAG ATAT=AT A=FTATATA TAAATATAGA TA'nT=ATA TATA FTATAT ATAAATATAT GTAAAATACT GTGAAAGAAG AATAGAATCT TGAGACCTCA AATrCACTAT GCCAAAGGGA AAGT-fAAGCT TGGGAAATGA GTCATGCAAA AACTGC=TC CTrirrCC CAAATACCTG TAATICACATG='lACFI AT=TATATA AAATGTAGAT GTACTrGAGCA TGAGATCCAT GCATAMT7C CCTCTAGTCC CTCTIT=A CATGTAAAGT GTAGACTCAC TGAGTGTrAC AGAGCCTGC CACAATGTAA ACA=TGTCT CAJTGCCAAC CCATC'=CG 1T7AT=CT TCCCCTCCTG =TGCTC1T CCCCTCTAAA GATGGAAG Fr CCCAAAACTC TCTJGGAAA AAGCGCAGGT CACAGATCCT ACAGTGAMr GTGMhC'= TACCTGGGAC AAAATAAACC TCTAATCTGT TGAGATATGC 'FrCAGT7ACT =IrGGMrA CAATATGTAC ATGTATGTAT ATAA'T1'ATA TGTATATAAT ATATGTACTT GTI=AACCA GAGGTATGPT ATTCAAAATC CAflCATCCT TACAATTACC TGCATTCTCC CACAGTATTT TCTGTGTCCC TGCCCCCGAG GT7GTCACTG CAAATCAGGT ACATGGATAC TGGGAGCTGA TGGGCTCCCC TCTGGCTACC TGGGCTGCTG AAGGGGCCAT AGACAGACCC AG=T~CCTC TCGTGGAGAG GCCCTGGGCC AGCGCTrGCGT GGGAGTGGGA TTACAACCAG ACTATAGCT7 CTTrCACCTGC TI1TCCTAT CAGGATrTCA TAAGAGGCAA TTGG 717rTTGAGGGTG GGGGCAAATC AGGGGGAG'FF GAAGAGGAAA T7GGGTAAGA 'TTrGAATAGT TGGGCATGTr GAATATrATG AATATCATCT CCCT=TCAA ATAATCCAAA WO 00/09525 PCT/US99/17712 EPI-109 61 ATATACCCCC AAGAAACAGG CTGATTAGAG GTGCTTCAAG GCTCCACTGA ATCTCCCAAG CTCTGAAGAT GTAGCTAGCT GTTACCGGAT TGCCGGTT CAAGCCTCGC CTCACATGGA CCCTCTTGGC AGTTTCTCGC ATGGGGGAAG CATCCGCTAC ATAGATGGGA ATGAAAAGAG GAAAGAAGAC GGTGCAAACT CAGGCACACC CCGGTGTCTG CCACCAGTGC TATTTAATCT CTGAGGTGTC ACCCTTCCTG GCTTTATTGT CTCTTCCTGG AAGTCTCTTG TCCTCTCCTC CACACCCTTT AATCAGGCAT CAAAGACTTr AACCAGTTTT GCTGTGTGCC CAGGCCCACT CATTCTCACT 'TTATGGCAA AGGGAGTGGG AGACAGAGAG ATAGCCAGAA AGAAGAGATT GGGGACCCCA AGACAAATGT TAGAATTTA ACCAAGGCCA CCCTGTGGAC AGGAGATTAT TGGGTTTAGT GGAAAGCAGC ACTGGCCACA ACCACACGTG GCAAAAGCAT CTATCGAGGA GTGAAGTTAT ATTTGGTGAA TGTGACCGGG AAGCAGGGGC AGTGGTGTCC TCCTGCCTTC CTGAGGCACT CTGTTCCCTT ACCTCTGCGA AGGCTTATTT TACCCCTGAG TGCTTAGTTT TGAAAGCCTT AGTTCCCTCT CTCCCATAAA AAAGCTCTAC TCTGCTAACA TCTAAGTTAC CTTTGCAGAG TCTTAGGTAG AGGGAGGAAA TCCCAATAAA GATTCCACCC TATCTGCAAA ATACAAACAT GGTATTrCTT GCATTCCCAA AATrGTGAAA GAAAATGTGT ATCACCACAG TAGAGAATGG CA'ITIT IGT TTGATCAAAA CCTAAATATA TTTGATGAAA ATGTGTCTGG TrCTAAGTTT ATTrCCCAGA AAGCCATGTT TACTCACTrG GAA'TTATAG ACATCTTATA ATATCTGAGT CGAGTAGGAG CTCCGGGCTC TACCTCACTC TTTCTCCCA CACCCAGGGG GAAGTGTAGG GTTCTCAGAC TTTAGAATAA AGAGGAATCA CCTGGACAAC TCACCTAAAA TGCACATCTT CAGGTCTCAT ACTCAGAGGC TCTGACTCAA CAGGTCTGGG TGGCGCCCAA GAATTTGGGC TTTAAATGAG TATCTCAGAT GATTCTAATA CAGAATGTGT AAGATGACCA GATCCTATCA CACTTAGATG TATTGGCCTA GGGCCACCTA ACTTGGAGAA AATGTTAGTA AGACCCCGTG GTTGGTGCTC AGCTATAGGT ACCAGAATTT TGATCAAAAT T7ACTATCAT TGTGACACTT CTCTTCGGAA CTGGAAGGCC AGAACCCCAC TTGTAAAGTG CTGGGAAAAT ACAAGGAAAA TTAGGGTGA GTAGCATT GAATTCTTAC ACATGGAAAG TAAATGTATA AGAAT7CT'A CCAATAAAAA AAAAGCAAGA GAGAATAGCT GCTAAAGAAT TAACACAAAT ATGTATATAT TAGTIATTCT CITITCTCCT CTGATTCCAG AGGACTTTGT AATTCCACTA ATrCTTCTTG AGCTTCCAGG ATGATCTGAG ACTTGAATTT TTCATGTGCT TTGCTTCC TATTrGGCAG CATCTTATCT TGAAGTTTCC GCTTTCTGCT TGGGGACCTA AAAACTAACT AATGGGAATT TCTTCAAAAT GAGCAAACTC TGGTGAATTC CCAAAGCGGA AGAAACAAGT GAGGATCGGG CTGGTTAATr AAGAGAACTT TrCCTGAATG TAGCCAGACT GTTTGCCGAC TGTTGTTAAC ATGAGGGAAG AAATACCCCT GGAFTAGA AGAGCCCCT GTGTTC CTTGGCCATT TGTGCTGCTT GTTGTAAG TCAGAAATTT CCTGAAGGAC TATTATTAGC TTTGTTCTCA CGTCAGAAAA CTTCTGCTCT GGCCACTTTT AAACATATAA CTTGGATT ACTGTATTAG AAAATGTAAC AATTACAGAC AGCACTAAAA GGACACCAAA GGGCAAAGAA AATGGGTAAC 71i TIT-CT TCCCCAAATC TAAAATAGGT GATTTTGGAG AAGTAGGAGA AAAACCTGGA 1TITCTAGAT CTCTTTAGAG CTCAACAACT GATATAGTTA ATTATGTAAG TCTTTGATAT TTGGAAATGA TTGGATTAAC CGGATAACAA TGAATATTTA AATACAGTGA TTrGGCCAGG AGCAGTGGCT CATGCCTGTA ATCCCAGCAT TTGGGGAGGC TGAGGCGGGT GGATCACCTA AGGCCGGGAG TTCCAGACCA GCCTGGCCAA CATGGTGAAA CCCCATCTCT ACTAAAAATA CAAAATTAGC CAGGCGTGGT GGTGCAAGAC TGTAATCCCA GCAACTCGGG AGGCTGAGGC AGGAGAATTG CTTGAACCCG GGAGGCAGAG GTTGCAGTGA GCCAAGATCA CGCCATTGCA CTCCAGCCTG GGCAACAAGA GCGAAATTCC ATCTCAATAA ATAAATAAAT AAATACAGTG ATTTAACACA AGAGATTrCT ATTCACACT AATGAGCTCT GTCACTGGGG CAAGCTTT TGCCTCATTA AGTCTCAGAT TTCCCGAGAG CTrATTATT TATACCAAGA GTGCTACT ACCGTCTCTG CTAGCTGTGA CATAATATGA CAAAAGGTAT AAATATGGGA AAAGGCACTA ATTTATATCA AAGCGTTCTT CGTIT-lCCT TGCTGTGAAG TITITAGCTA ATAATTCATA AGAATATACC ATATTTAGAG TGTTTACTAT GCATGGGCCT GGCACTTCAC ATACATTGCT TCTTACAAAT TTrACAAAGT GAAAGGTAGA TATTAATCTC ATITTATGGA GGACAAGATA GAGATCTGGA GAGGTTACAT AACT7GCCAG TGTrTCA GTTAATAAAT GGTAGGGTGG AGATTCAATC TGTGTTACTC TAAAGTCCGT GTCC1TI11A TrGGCTCCAT GCCTACTCAG ATAAATCT CAGCAGGGAA GTAAACCTTA GTFTACAT GAGAAAATGT TACAGCAGCC TTCTCGGCTT CCTTTACCCC CATCCCAGTT TCACGAGCTT AGTGCCTTAG ATCGGGTTCC TTTAGAAGCA GACCTCGAAA TAAGGATGTG GGTGCCAGTC ATTrATTGAA AAGATGATCC CAAGAAAGCC TAGTAGGAGA GTGAGGAAGT GAGATGGGGA AAGGAAGAAA CTCCACAAGA AGTGTGTTAA TAAGCAGGTT ACCGCTGTGG GCAGCCATGG GGCTCAGCTG CACTAACAAA CTCTGTCTAG TACAGAAAAC CTCAGGGTCT CCCCAAGGAG GGGCAAGAAG TCTGCCTAGG GTATATATCC GCCAACTCAG TCACTGGCTG AGAGCTGATC CTGGGAGGGC ATGGTTAATT CCTCTGCACT TTCAAGTGGA TTCCTGTGGT CAGAAAAAGC CCTCTACAAT GAATTCCAGA TGCTTGTATT TAAATCTGAC ATGATCTGAA TGCTGTGTTG GGACAGGGTG GGCGTTATTA GTTCTGTC ATTACTGTAA CAGATrACTA CAAACCTGAT GGCTGCAAAC AACACATATT TATTATGTCA TAGTTTGTGT GGGTCAGAAG TACAGGTTAG CTCAACTAGT TTCTCTGCTC TAGGTCAC ATTGCCAATA TCAAGGTGTC ATCCAGTTGG GCTCTrCTTG GGAGGCTTGG GGATGAATCC ACTTCAAGC TCATTCAGAT TGTTGGCAGA ATCCAGTTCC TrGTGGTTGC AGGACCAAGG TCCCTGT7GC CTTGCTGGCT GTTGGCCAGG AGTCATTCTT AGCTrCTAGA GACTACCTGT ACTCTCTGAC TCGTGTCTCC ACTrCACCTT TCAAACCAGC AGCGGCTAGT CGAGTCCCTC TCTrCAAATG TCTCCAACTG TGCCTTCACC TCATTTCTCC TCTGTGTACC ATGTCTGCCT CTACTGCTTG TAAGGGCTCA TGGGATTACA TTGGATTTAT TCAATCCAGG ATAATCTCCA TATTAAGG CTAGCTGACT AGTGATCTTA ATTCCATCTA CAAAGTCCCT TCCAATAGTA CTGTATTAGT CCATTCAT GCTACTGATA AAGACATACC CAAGACTGGG CAATTCACAA AAGAAAGAGG TTAATTAGA TTTACAGTTC CACATGGCTG GGGAAGCCTC ACAATCATGG CAGAAGTCAA GGAAGAGCAA GTCATGTCTT ACATAGATGG CAGCAGGCAA AGAGAGAGAG CTrGTGCAGG GAACTCCTCT TTAAAACC ATCAGATCTC ATAATACTTA TTCACTATCA CAAGAACAGC ATGGGAAAGT CTTGCCCCCA TGATTCAATT ACTCCCACCA GGTCCCTCCC ACAACATGCA GGAATrCAAG ATGAGATTrG TGTGGGGACA CAGCCAAACC ATATCAAGTA CCTAGATTCA TGTGATTA AACAACCAGG GAGCAGAAAT CTTCAGGAGT GGGGGGCATC TTTAGAATTC TGCCCACCAA GGCTGGGCGC GGTGGCTCAC ACCTGTAATC CCAGCACTT GGGAGGCCAA GGTGGGTGGA TCATGAGGTC AAGAGATCGA GACCACCCTG GCCATGGTGA AACCCCATT CTACTAAAAA TACAAAAATT AGCCAGGTAT GGTGGTGGGC ACCTGTAGTC CCAGCTACTC AGGAGGCTGA GGTAGGAGAA TCACTTGAAC CCAGGAAGCG GAGGTTGCAG TGAGCCAAGA TTGCGCCGCT GCACTCCAGC CTGGGAGACA GAGCAAGACT GTCTCAAAAA AAAAGAATTC TGCCCATCAT AGTAGGCTGT CCTACAGAGA CATAACCCAG GAATTAGGTG AATGGCTAAC CTAAATTAGC ACTGTGATGT GITCTGAC TTGGTCCTTA TAGCTCCTCT GCTTAGATGT GGAACTAATC CATGAATGCA AGGGTTTGTC TAGAGTTTA AGTGGGAGTT AAATATCCAA AGTACAGGAG ATATTATGGG TGCCTCATCC ATGTCCCCTT GGCATTTATC TTCTTGGAT AACCCAACTC TATTAGTTTT TATATCTCAC TTGTTCCTAT ACTCTGTGAA CTGATGTCCC ATAAATAGAC ATTTCATITr GCCAGTCTTC TTGAACAATA ATTACGATTA TTAATCTAGC AGTTATCATF AATTGGCCAC TrCACATTAG ACACAGCACT TAGGACTTAA GAATACCATG TCATTTGATC ATCATAATAT GGTCAGGAAT TAAGTATTGC TATCCAAATT TTACAAAGAA GGCACTGAGG GTTAGAGTTT AAATAACTTG CTTAAGATGT CATAGCCTGT AAGTGACAAA ACTAGGACTC AAATACAGGT CCATCTGACT CCAAAGTCTA TGTTCTTGGC TACCACACTG CCTCTCCTAC AAGTGACCTG TGGTTITACT ACTATATTCA CACTCTACTA ACTTACCAT CTCCCATGAG TCTGTCTAGA GGAGGGCACA WO 00/09525 PCT/US99/1 7712 EPI-109 62 CACAGCACAG AAAACACATG AATGCAAAAT AAGGAAGGGC CTACT=ACTA CACAGAGCCA 'rTCTAATACC TGATGn7TGC TCTAATCCAG TITACTAT7 AATrAGTrGC TGGTGCCCAA GTITIACTG AGAAATGGGG ATAA'IrGG AAGTCATAAT GATGCC'ICT TCTCATAGGG TATIAM~ GTTGTrGTAT CTCCAGGCCC CAACACAGCC TGGCTI=AG TAAATGATCA AAAATACCTG FrGAATGAAT AAATGGAGTC ACCTGAAACA TGTTAAACAT T7G1TCATGT GTCCTAATCG TGGAITTCAG GATAGTAAGC ATCCTAAAAG GAAAGCATGC ACACTGTrCT TGCTACAT~rA A TrCTCACA ATATAAAAAA AGAAAAGCAT GTGAAAAAAG CTGCCAGCCG C-TGTGTCTCC TAATATCAAA CTGAGCACAG ATATGGAGAA GCTAAGGGAG AGGGATGATG GGCCATGCCT CTAACCTCAT CATGGCAAAA GTCCTGGGGG TCAGACCCGA GGAGAGCAGG AAGTGTC = TGAGGGATAC ATTCCACAG TGGAAATAAT GAGACTrAAA TAAATATTAT ATACACAGTr CAACTGT1T1 TATGTGTAAA GGTAGTAGGT TI17CACAGTA AGGAAGCACTr TCTTITIT 'TrrGnI7GAG ACAGAGTCTC GCTCTGTCTC CCAGCCTGGA GTACAGTGGT GCTATCTCGG CTCACTGCAA TCTCTGCCTC CTGGA FrCAA GTGATrCTCC TGCCTCAGCC TCCCGAGTAG CTGGGACAAC AGGTGTGTGC CATTACACCT GGCTAATTT TGTATTITA GCAGAGATGC GGTTrCACCA TGUGGCCAG GCTGATCTCG AACTCCTGAC CTCAGGTGT7 CTGCCCGCCT CTGCCTCCCA ATc3TGCTGGG ATIACAGGCA TGAGCCACTG CACTCACCAA GCACTTrCTAC TGATAGCAT7 TACAAACCCT TC7TAGAATA TFrAAAAATT CTAAGAGAAG AGTAAATTGA GCCTICCCAA CTAATACTAG GAGGT7ATAA C=~CATACC AAAACTGGAC AATGC11GCA CAAAAGAAGG AAGCCAATGA GGCCACCTAG AAGGAAGACT GGGCAT7GGG CCCAGTGAGT CCTGGAAACC TCATCTGTGC CAGCCACCCC GGCATGGCCT GTATGAGTGG ATGAGGGTGA CTrGTCCACA GACAATAGCC ATCTAGCTGT GATAAAGGAG TCAAGGTAGT CAGCTGCATC TCT=CACCT GT7GCCAAT GTTACACAGG TTGAAAAGCT AAGGIMATG TAAAGCAAGC ATCAAAGATG ATGAAATGAT CAACCTGACA ATGAGTACTA TGCTGCATTG TCCAGAAAGG AACTGTGGAA GA1T=GGGC TG3AA=TCAA AACAGAA'IM CCTCACTCTrC TGGATGT-rGG CTFACTGGC CTTGATGTI7 CAGAGGTGGT GCC1TGTGT TGTTGAACAA TGTTGAT1T GGAGAGAAAA CAGAGTrGAA AAACCCACAA GTCATTCCCT GGGGAGTA FT ACCGGAATAC AGAGGATAAT 'PTCAGCAAGC CAGCAAGGCC TCATCTCTGC TI7CTAATAGA TAGGAAGAAA GGAAGAGAGG AACAATAC= ITTAAGAAG CTCAGCT=A TCGCCTTATC TCATAGAAAG ATGCCTCCAG TCTGTCTGGC TAAAGGTAAT TGGCATGGGA AAGTC1TAT CTGTGArTCT AACAAGTGGA ATGIMCCCT TCATTAAGAG AGCCTGTCT GG=~GGGGA AATGAAACAC ITT'CTCCGAT ATGAGTGGGC TGTAACCCCT GCTACTAAAT ACTCAGAAGA AATAAGGCGG TTGTGGAGCA GTCAGGAATG AGTCACTGC CTCCCTGGAA TATTCAGAAA ACTGAATCAA AAGTACA'ITC TTCTGGGnF7 TCTTAGTCTA ATAGACTAAG GGTCTCTACT FrG'ITAAATT TCTGGGAAAC AGCATAGAAT GGGAGAAAAA ACTGGTCACT GTAGTCATGC AAATCTGCAA AACAAACAAA AAAGTCTGGG TA'FrGCTGCT AACTAGCTAT GTGACCTTAA GCAAGGTArT7 AACTCTCTCT GAATI7CAGG Tr=TCATCT GTI7AAATAGC ATATCTGTAA AATGGGAATT A'II1CATAT CATAATGCTG TAGC=rAAA AAATAAAATA AAATGGATGA GATAATCAGA ATrAAAGAGC CTGGGATATA TAGTFTAATAT ATAGCAGCAT GTAAAGATCC TGTTAGAAAT GCTAATITA CAGTTAACCA TTTGGAGATG ATCCGCCAAA GCTGCTAGTG TAGAGGCAAC TGAGAArTG CCTGTCCIC AGAATATGAA TAAATAACTG TCAATGATGT CTCAAGCCTA GAAAAACCTA TCCATCTGGA TGGGTGGGAA ATITCTAGGC TAGTATrGAG AAGCCCAM~ =TGGGAAAT AGGTCCTGGA CTGAGTGAAG GAAAAGAAAC AGTAAAACCC ATGGTAAAGC AGCAAGGCTC TCTAGAGGCT CTGGAGAGGA TGAATrGAAT TCTAGAAGAT GAAGTAGGGA AGACGCMTA Cc=rTIGTG AAATGGATTC AAAGATTCAA AGACCT7CGG GAATCTCCAA TrGTATAAAT GGCACCATAG CTGTATGTTC CATGGAACAC TAC=CCCAG AGATGCCCAG TGAAAAAAGA ATGCCACAGT CAAATAAGTr TGGAAACACT CCAITrATGTG GCCACCTCCT TGAAGACTCT AATGCACATT AGCATGTrAA ACAGTC1GA GAAGTCCTGC AGAGCAGAAA 'ITGCTrCACA TCTGCTAAGC CGGCAG'IMC CCAATATACT TGAT7ATGGA TAGTTITC CTTACAACAC CArrCTCTGA TATGCTrCCA ATGACATGAA ATAAATATAT ATGCATGAGG TrCTTCATrA GGGCATACT7 T17AATAGAA AATATTGAGA ATAATCTAAA TATAAATGCA CAGCATTAC C'TTTCTGCA TAAACTATAT ACAGGCATAC C~rGGAGATA CTATGGGM~ GGT7CCCACA ATATCTCCAA AACCACA FrC GGTITATGA CCACTGCCAT AAAACCAGCC ACATGAAMT 'Tr7GGTrrCC CAATGTATAT CAAAGTTACA TTTACTAT ACCATAGTCT ATTATATATA CAATAGCA'Fr ATATCTAAAA AACAACGTAA ACACCTrAAT TTIAAGGCTGT GGCTGGTTTG A=rTCTACC CAGACCACTA AAA=l~CTT CATATCAGCA ATAAGGCTGT TrCACTICT TACTA'ITT TGTGATAGCA CFI=C=T C=~CAAGAA 7=TIC='~ CTATrCACAA TFrG1GAT ACAAGAGGAC TAGA=TAG =TATCTCAG FI1TAAGGTGT rITACA~rGTr AGCTAAAAAT GCTAATGATC ATCTGAGACT TCAGCAAGTC ATAATCTIT7 GCTGGTGGAA GGTCTTGCCT CAGTGTrGAT GTCTGCTGAC TGGGTGGC'Fr TGGCAAITIC TTAAAGTAAG ACAACAATCA AG'FIGACAT ATCAATTGAC CCT7CCTGTC ATAAATGATr TITITTCT CTGTAGCCTG CAATGCTCT TGATAGCAT T7ACCCACAG TAGAATITC AAAATTGGAG TCAATCCTP CAAACTCTGG TGCTGFI=A TCAACTAAGT 'FFATGGAGTA TFrAGAAATCC =TGT7GTCA MTCAACAAT GTITCACACCA TCTTCCCCAG GAGTATA'ITC TACCTCAAGA AACCAC1TIC M~GCTCATC TATAAGAAGC AGCTCCTCAT CCACTAAAGT TrTATCCTGA GAT7GCAACA AT7CAGT7AC ATCT7CAGGC TCTACTTCTA AT~cTAG FTC T='1GCTGTr TCTATCTCAT TTGTGCTrAC MTCTCCGCT GAAGTCTGA ACCCC17AAA GTCACTCATG AGGGTTGGAA TCAAcCTT= ACAAACTCCT GTI'GATGTFIG ATATI=GAC CTGCTCCCAT GA'ITCATGGG TA'T~CT7AAT GGCATCTAGA ATGGTGAACG =FTCAGAAG GTXTCAGT-T GGC'=GCCC GGATCCATCA GACGAATCCC TATCTATGGA AGC1TATAGAT TTATAAAATG TA'IMCTIT I7GTGGGGG CATAGCGTCT CACCCTGTCA CCCAACCTGG AATGCAGTGG CACAGTCATA ACTCACTGAA GACrCAAACT CCTGGGCTCA AGTGATrC1 CCACCT-rGGC CTCCCAAAAC ACTGGAT7AC AAGCT7GAGC CACTGTGTCT AGCCCAAAAT GTATATCATA ACTAATGAGG CTrGAAAGTC AAAGTGACTC CrTGATCCAT GGGCTACAGA ATGGACGCTG GGT7ACCAGA CATGAAAACA ATACTCATCT CCTCATACAT CTCCTTCAGA GCTCCTGGGT GAGCAGGCCC AT7GTCAAAT GAGCAGTAGT ATCTTGAAAG AAATTTr TCTGAGCAGT AGATCTCCAC AGTGGACT7A AAATAGTCAG TAAACTATGC TGTAAACAGA AGTGCTGTCA TCCAAGCTCT G'TTTCCAC TGATAGGGCA AAAGCAGAGT AGA'rFGGCA TAATTJC'rCTA GGGCCTrAGG AT7MTGGAA TGGCAAATTG AGCATTGGCT TCAACTI rr T f ITrITMGAG ACAGAGT=T GGTCTGTCAC CCAGGCTGGA GTGCAGTGGT GCAATCTCGG CCCACTGCAA GCTCTGCCTC CTAGGTrCAC ACCATI'CTCC TGCCTCTGCC TCCTGAGTAG CTGGGACTAC AGGCACCCGC CACCATGCCC GGCTAA1TI 'rGTATI=A GTACAGACGG GG=TCGCCA TGTI'AGCCAG GATGGTCTCG ATCTCCTGAC CTCGTGATCC ACCCGCCTCG GCCTCCCAAA GTGCTGGGAT TACAGGCGTG AGCCACAGCG CCCAG3CCTGT =TCAACTrA AAGTCGCCAG CTGTGTTAGC CTCTAATAAG AGAGTCTGCC TGTCCMICA AGC1TGAAG CCAGGCATCA TTCTCTrCTC TAGCTATGAA AAT=TAGAT AGCATCTTCT CCCAATAGGA AGCCATT TATGCCCTAA AAATCTGTCG TF7GGTGTAG CCACCTTCAT CATrGATCT7 ACCTAGATCC GCTGGATAAC 7rACCACAGT GTCTACATCA TITACFCTGC FrCACCTrGC ACT1TATGT TATGGGGATG GCTC=TTCC TCTAACCTCA TAAACTAACC TCCACTAGCC TCACATT= CrI=ACAGC TTCCTCGCCT CTCTCAGAGT TCACAGAA'IT GAAGAATGTr GGGC=~GGA TACA='~G GT7FAAGGGA ATGCTGTGGC TGG'ITrGA'F' 'TTCTATCCAG AACACTAAAA CTTCAT ATCAGCAATA AGACTGM~C AC'==1AC TATIT=GT GATAGCACTr FrCCI=CCT TCAAGAA717 r TC=CTA WO 00/09525 PCTIUS99/17712 EPI-109 63 'FrCACAA'T GACCGTITGA TATGAGAGGC CTAGATPTA GCCAATCTCA GTPACACCA TGCC'T=~C ACTAAGCTTC ATCA'ITAG C17=FA=fl AAAGTAAGAT GTGTGACCCT TCC=FCATT TGAACACTTA CATGATGATG CCTGGM~CA AAGCTrGAAA GGACAGGCAG ACTCTCTrAT TAGGGGCTAA CACAGCTGGC GAC=F~AAG 'FrGAAGCCAA TGCTCAA TT7 GCCATTAGAA GCCA'ITGTAG GGTrAATTAA 'FTrGCCTAAT TrTAATAT-rA TGGTGTCTCA GGGAATAAGG AGGCCTGAGT AGAGGGAGGG AGATGGGGAA ACAGCCAGTC ATCAGAGCAC ACACAACATT TATCAATTAA GT-I7ATCACC TrGAGGGCAC AGGTCATGAT AC'ITCAAAAC AATTACAATA ATAAAATAAA AAATCATTGA TCGCAGATCA CCATAACAGA TATAATGATA ATGAAAAATT TGAAGTAT7G TGAGAATTAC CAAAACGTGA CACACAGACA CAAAGTGAGC ACATGTCAT-r GGAAAAGTGG TGCTGATAGA CTTACTCAT GCAGGGTTGC CACAAATACT CAATCTGTAA AAAATTCAAT TATCTACATA GTACCATAAA AACAAGGTAT ACCTG'I=AT ATAATCAAGA CCAACAGAAC CCTAGAGAAA ATAGCTCACT CCCTAGCTCG GAGACAT7CT AACCAACATA CAC'FrACC= TC'Tr=GCT GTGTACAGAA FECAAATCCC TGTCTCAGCA AAATTGCAAA GTATCAAATG TCATGTCCAT CTAATACTCA AAACTGCAAA TGTTAAGTCT TGTAAGCCCA GAGACCACTG TATATACAAG TG FrGCTATA AGCATITAGTT1 CTCTCCAAA GAAAATAGTC CACTTGGTAG AAACAAACAA AAAGAAAAAA AAAGAAAGAA AAAACATI1 TTACAAGAAG ATTCAGTC7C 'FrACCTACAT AAGCAAAAAT ATGAGATGT'T CTCTTATCAT =TICCATCT ATCTATAAT CI=GGTGCT GACTrAGACA CTCATITCC T-TTGTACG TGACCATGTA AAAGTrCAAG TCAAGAAAAA CTTGTITGA CAIT]WI= GCTGAGTGAT GGGTCCCTAA AAGAAA'TTTG GC'T]GCT TGAAAAGTTC AGCATGATAT TGTGTGAAT7 TTCATGGCT AATGATFIT AGAACAGTITG TGATGTGTr AGGTGTITA AGAATATGAA GCATFCAGTG G'I=AAGTrG GTTGU'ATAA AATGAAAGAA TATGAAGGAA AGCCTCTG TCTTAGAACA CACTGATI7CA CAAATAAGCA GCTrVCTCA AAATG ITGTA A'ITACAAAAA TJTCCAAGGCA AATATAATAA ACTCCTTGTC GGTGCTATGT CTAGAAACTr AACAGCCCCA AAGAAAGTCC TGACAAGGCA AAAAATATAT ATATATATAC AAATrGTGGA AGCAGGGTGT TGAAAGAAGA ATAAAGACTA TATAAGGACA AACTGTAA AAGGGAGGGT ATCC=GAAA GCTTGACACT TGACTC'TIT GACGAGGCTG AGGGAAAACA CTCAG'TTrCA TAGATTGCTG GTACGGATGT AAAATAGTGA CATCCCTATA GAGAGGAA'IT TGGCAATATC TAGCAAAAGT GCTTATGCAT T7ATT=G ACCTAGTAAT CCCGCTTCTA GGATTAGTGG TGAAGATACA CCTCAACAAT AAAAATATAT ATACATTAGG 7rAFrAGTTA TGGTIAATT FITAATAGCA AAATATIAA AACAACCTAC ATGAACAAAT AGGAGAC=A CTGAATAAAC TATGGTATAT CTGTACAATA AAGTGCAATI' CACTTATGTT GTTrAAT17GT TCCAAAAATC CAGAGCCAAA GAGTA=TGT TATGCTCTCT 'FrAGTATAAG AAAGGGGAAA TAAGATATGT GTGCATCTGT 'FrATTGT GAAAATAAGT ACAGAAAGGA TAAGTAAGAA ACTAGTAAAA CTAG'7ATCT CCTAGTGTTA GTAGAAATAG AATGAAAGTG AATTAGGC-17 CMTGAGTAT ATG'IMATAT ATAGTITGA CTI=GAA'Fr ATGTTTATGT 'ITACATAGTC AAAAATATAA A'FJAATCAAC AGAAATAACA AAAAAAGAAG AAATCACAAG C=~AAAA'Fr TAATACAAAC AGAAATAATT GAATCTAACA GTATATCAAA GTGATAACGT AAACTCAGAA GAAAAAAACA TAATCCAACA TACCAGTGGA ACACAATATT CTAACTGTAT ACATTCAGTG GT'rATAGTCT AAGGACAAGA AAAATTGCAA AAATATCT7G AAC'TAGCT TGTAGGA'ITT TTAYTGGTAG CAATACTAAT GTACTAATTC TGAAATrAAT GTTCGTGTAT TATAGAATrG AGTAAATGAA TAAATATGTT GATGTTTFG GGAACTAAAA 'FrATCATTCT GGGAGTAGAG AAATATAAAT ATGGACTrGG CAAATGAAAC AAAGACCTGC AGAGAGATAA CCATATAAAC TCATrA=FT AAAAAITATA AGTGTCCTAG CTCTGTTACr GAAAAGGCCT AGATTCAATC TTATCI1GAT AGACAGGAGG GCACCCC1T CTCAGAACAT GGMI1CCAAA TGCCATTCTC CATTAAAAGG AACAAGGTCT TCTFGGAGAA AAGACTGATT CTAGGTCTGG ATTAGGTAAA GTACAACG'Fr AGTCTGGAAT 'Tr=GCTGA ATCAGAAGTA AGAAAGTGCT CAAAAACATG GGAACATGTC ACAAACACAC GTGAGGCAAC TTGAATCCTC ACTGGCCATA MFAGGACAA TCGAGCATCA AAAAAAAAAA AAATGTTGAG AATAATGGAT TCTAACACTr AAAACAAAAA ATAATCCATA GCCCACAGAA GGGGAAGAGA GGGGGAGCTC 'TA'IACAG ATGAATATCA AATAGCAAAG ACAGAAGAAA TGACAGAA'Fr AGAGAAACAT CATITGCAA AACACCACTG TAATAATCAA rrCAGGCAAG TATTATFAAT GGATGTATI'A CTATrGCGTA AAACCAGTTG GGGAACAGGA TATI7CATACA GTCTGAAGGT GTCACCCTAA ACATAACTTA 'ITACAAGTGG AAAATGGTGC CT=ACAATG AAGAAATCTA GCAGAAACCA T=TAATCTA GTGATCAAAC TrAGTATCAC CAATAATGGA TCATACTGAG TCATGTGTCT CCTAATATGA TGCACCAGGA AGGATGCAAC GTCATGAACG 'FrGTATrCTT T7GTATTCAA CAGACCACCC AGGGTAAAGG CAG~C'IrC ACT7ACTAAT CAGAATTGTIT GG1TrAAFF CAT1TGGAT MFAAGATT7 CTTAC'=CT TGTCAGCTCA GAAATITATT TAAGATGAT7 'TrATCTIT AY7CAATACT 7rAGCTTGGA GAACCATTCA GAGTITCTAA CTCAT7GTAT TGCCAAAAAT AGAAAACAGC ATGGIT]TCT TFrGAAAATGT CTAACITAA AGTrACTTGT GTGTGTCACT CAGATTCACA TAGCTIT GCCTAGTAAT GTAGTATCAT GTGGCAAGGC TATAAAAATG TrACAATCT 1TrATrr7AAT ATGACTCTITG AGAGI=A7T CTAAGGAAAT AATTGAATAG TAACAAAACA CTATTAACAC AAAGCATAGC AAITGA=~ GGGCAACCAA ACACTGGAAA CAACCTAAAT GTCCATTACA GGAATCA Tr ATGAAGCAAA CACTAAAATA MIArrGTGA AGATTATGAG AACATAGAAG ACAGT1TATGA GAGTAAATF GAAAACCTGA ACACAAAACT TACATATACTr CCAATrGTAA CTTATAAAAA ATACC3TGCAT ATAAGGATAA AACAGTACAA ACAAAAAAAT AG'FrGCG'rrA GATlGGTAGA A'FATGGCTC C'ITGCTGT CT7AATITI TCCI=rACA TI=GATACA T-rATIAAT =ITAATI=A AAATTCAAAA GAAnITGCCA CTCATCI=G CCACTrCAAG GAAAAAAGAA ATGTGT7CGA lTArrCTGTT CTTAGTATAG TT=GGCAAT TTCCTCACGT GTAAAAAGAG AATACTATTA ATAATITCAG TATCTATAAG ACAATATAAA A'FrAAAGAAT CTAGCCCAGT AACTGGTACA TGGAACGTAA TTAATAAATC A'ITATGGACT T1TITCTCA CACCCAAGTA GGGAGGAATC AGTGGTCCCC TAGAGGCCCA GTGTAGAGGT GGCAGCACCA ATCCCTAGGG GAGAAGATCT TGGTGATGAT AATTCCTGAG CAGACAGTTA GCTGAGAAT'T CAAGAGCAGA AAAGTAAGAA AGAAACAACT TCTTGCTAAC ACCT=CCAC CCACGTFTCC CTG~rCTGT7 GTACTCTGCT TACCCI=CA TGGATGGAGG CAGAGGAAAG AGAACCAAGT TrGCTC'FrAG TCATrCACTA TGT7GMIAA TCTGCCTTCC ATC1T1CTTA TCAGTrCAAA T7AGAATGTA GACCTGAATT TAAATCCCCG TTCTGTCAGT TATAATGTGA CCCTAGACAA AACACA'FrCT CTGAACCTCA GAGAACATTC Y[CATrGTA GAATGGGAAG A'ITAATCTAT A'ITCCAC=G GATGGCAAGT C'flTATAAA CT=ATAACC TAAACATGTG TGAGTrGCT.A GTATCATTAT GTTGGTAAAG TTATTCTGAG ATATGATAAC AGAACTGTF TGTCTAACTC CACTAGCATG G FrCAGGTr AGAGAGTGTG GAATrAAAAG GCITATCCT CAAATATGAC FTAAATCCGA TfFFCTCAT CCACTTCCT CCACAAACAA ATCCTCAGGA AATGACAAAC =TACATGGT TAAACATCAG =ITT'1AG TCITGACAT CCACATGGTr AAATCATACA TTI'GAAAACT GCrrATA'I= GTGTFTGTCTA TGTCTAAAT7 GAAAAGACTr ATFGAGGAAT AGAAGACTAC ACAThI1CA GCAAACACTG CACGTrTGC AGAA=~CCC CAGGCACCAG TCTCCAGGAA ITATrGGCT ACTAACAATA CTAAGATATG GATGAATGAG GAAATCAAAA TGGAGATCI GCAAGT1TG TGAGAATGGG TGAATGGTCC AAATGAAGAG ATAAGTTGTG AAATA'ITAGT ACAAGTAAAA ATTIA=IACA ATGAAAGACA =ITGTCAAT AGCTATGAGA AT1TACCAT TGACCCAGAA AI7CCA'I=C TTCTCAGA AATACCCACG TAGGTATACA TATAAAAAGT TA17CATTAC AGTATCG'FI TTCATAGGAA AAAGI=rAA AAATCAGAAG CTATCTAAAC TATGGTATAT CTAGGTCATA GAAATCAAAT GACTAAAAAT GTTAATATAA GCATATGTTT TTAAA'FrAAC TrGGCTTGGG TCTrCAGCAA AATTGGCTTC T17AACAT7GC ACTCCAGAGT WO 00/09525 PCTIUS99/17712 EPI-109 64 TAGACTTACC CACTCAGTCA CTTATCATGC AGGAGCAGAC TCCTAATACC ACATATCATA GAGCAGAGTA GGACACAGGT TCTCTGCAGG CAGGCAAATC CCAAAGAGAA GGGAGGAAAG GGCTGAGACA CTGCATGGTC AATTTCTTCT GAACTCTGCA ATGTACGGAG GTGGACAGTG TCCACAAAGA TTGCTCCCCT GGACCCACCA TCATAATAAC ACAACGGCTT TGT=TTGTT TTGT1I11GT TI-1GACAC GGAGTITGC TCTTGTTGTC CAGGCTGGAG TGCAATGGTG TGATCTCGAC TCACCACAAC CTCCACTTCC TGGGTTCAAG TGATTCTCCT GCCTCAGCCT CCTGAGTGGA TGGGATTACA GGCATGCACC ACCATGCCCA GCTAATTTTG TA'ITilAGT AGAGACGAGG TTCTCCACG TTGGCCAGGC TGGTCTCAAA CTCTTAACCT CAGGTGATCC ACCCGTCTTG GCCTCCCAAA GTGCTGCGAT TACAGGTGTG AGCCACCGCG CCCAGCCCAC AATGGCCTT TGTTTACATC TCTAGTGCAG CACTCATTTC ATGTTCTTTC AAGAAGAATA CATATTrCAT CIT111ATT TATACAGCAA TTAGCACAGT GCCTGGCATA AGGAAAATGA TCATTAAAAG CTGGGTGAAA AACCTAATAA AGCTACTGAG GATAGGAACT GCAGACCAGC ATGGAAAGAA AACTATGAGC CAGATATTGA CATCATCCTG AAAGGCAGAA GATAGTAT AGGCAAGAAG TATGCT11iG GAATATAGAA AATCTGGATT ATGATAAGAA AAGAATCATA TTTGTCTTAT CTTACCTACT CACTTCTCAG TTCCACATGT TTCTGAGGCT GTTTGTCCTT ACTTTCTT CTGTITATC CACTCTTCT GTTCTT7AGA TTGGATCATT CCTATTGAGC TGACATCAAG TrAACTGACC ITilATTG TCCAAACTGC TGTTAAATGC ATCCAGTGAA 1TITAACTT TATATAGTAT ATC=il-AGT CCTAGAAT CCACATGAGT TTTTAAGTT TCCATTTCTC TGCTGAGATC TCCTATTTGT TCATTCATTA TGACCATATT TTCTCTACA TrATTGAGCA TAATTATAAC AGCTCTTCTA AAATTCTTGT CTGCACATTC TAACACCTGA ATTATTCTGG GGTCAGTCTC TGTTACATTG CCTTATTACA AAAACAGTAT AAGTCACATT GCCTTGTC TTAATATGCA AAATGATT TGATTGCAGA CTAGACATTT TGAATTAAAC ATTATAGAGA TTCTGGATTC TCGAGAGAGT ATTGACTTGT TTTCCATC AGGCAGGTAA CTTGACTGGA CTCAAACTCC AAACTCTAGG TCCTCTGTAA TGGGCAACTG CAGTAATCT TGTTTAGTTC TTTAAGACTT ATTGGCCAGG CACGGGGGCT CATGCCTGCA ATCCCAGCAC TGTGGGAGGC CAAGGTGGGA GGATCACCTG AGGTCAGGAG TTCGAGACCA GCCTGGCCCA CATGGTGAAA CCCTGCCTCT ACTAAAAATA CAAAAATTAG CCGGGTGTGG TGGTGGGCGC CTGTAGTCCC AGCTACTCAG AAGGCTAAGG CAGAAGAATC ACTTGAACCT GGAAGGCAGA GGTTGCAGTG AGCCGAGATT GTGCCACTAT ACTCCAGCCT GGGTGACAAA AGCGAGACTC CCTCTCAAAA AAAAATTAT TGGCACTGCT TGGCATCTGC TATGAATACA TGAAGTTCAT GGGTCAGCTA TAGATCTGGG CACGTTATAC ACAGAATTTG GGTCTCCCTT TCTCTGGATT TCTCC'IT1-C TGGATCTT TTCTCATT CCAGCAGCTG TGGTTGCCCT AAACTCGGTC CTCTGTTTCT TTACGGCAGT AAGATT7GGG AACTTTAGG TTACCTGC CTCTCAGACA AAATAAAAAA TAATTCAT CTTGATGCTA CTCCTTTCTT CCAGATGTAG ACACCTCTCT AATTTCCAGT TGCtTIAT TGCTCTCCAG AGTCTAAAGA TTATCATTGT TTTCTGTGGG AGAGTTGGTC TGATAAAAAC TACTCCCCCA AAACTGGAAG CTGGAAGCTT GTAATTATGA ATAGACTTTG AGTAGTATTC T7CTTTGGAA AAGGAITA ACTACTCCCT ATGTACTTCT TTA1TTCCTG lTiT1CTCAT CCGTAATCTT TTTATITTCA TACTTCCTAA GTCAGACAAT TTTCCTACTT GAAGATTCAG TGACTGCTAT CAAATGACCC CCATAT7ACT AAATACAATA TCCCCAACTG CATATAAA AAGAAAATTT ACTGTTTATT AGTAAACAAT GTTGTAGAAT AGTAAAATAT TGCTGGGCTT TGGAGCCAGA TAATCAAGGT TAGAATCCCA GATTCTAACT TACTAGCTGG TGTATTAGTC CTCTCATG CTGCTAATAA AGACATACCC CAGACTGGGA GACTGGGTAA TTTATGAAGA AAAGAGGTTT AATTGACTCA CAGTCAGCA TGGCTGGGGA GGCCTTAGGA AACTTACAGT CATGGTGGCA GCAAGGAGAA GTTCCAAGCA AAGAGGGAAA AGCCCCTTAT AAAACCATCT GATCTTATGA GAACTCACTC ACTATCACGA GAACAGCATG AGGGTAACTG CCCTCACGTf TAATTACCTT CCACCAGTTC CCCCCCATGA CACATGGGGA TTATGAAAGC TATAATrCAA GATGAGAT GGGTGGAGAA ATAGCCAAAC CATATAATTC CACCCCTGGC CCCTCTCAAA TCTCATGTCC TCACATTTCA AAACTCAATC ATGCCCTCCC AACTGTCCCC CAAGGTCTTA ACTCATTCCA GCATTAAGTC AAAAATCCAA GTTCAAAGTC TCATCTGAGA CAAGGCAAGT CCCTTCTGCC TATGAGCCTA TAAAATCAAA AGCATGTTAG TTACTTCCTA GATACAGTGG GGGTACAGGC GTTGGGTAAA TACACTGATT CCAAATGGGA GAAATTGCCA AAACAAAAGA GTTACAGACC CCATGCAAGT CCAAAACCCA ATAGGGCAGT CATTAACATT AAAGTTCCAA AATGATCTCC TTTGACTTCA TGTCTCACAT CCAGGTCACA CTGATGCAAG AGGTGGGCTT CCAATGGCCT TGGGCAGCTC TGCCCCTGTG GCTTTGCAGG GTATAGCCTG CTTCCTGTTT GC1ITTCAC AGGCTGACAT TGAGTGTCTG TGGCTITTCC ATGAGTATGG TGCAAGCTGT TGGTGGATTT ACCATTCTGG GGTCTGGGCC AGGTGCAGTG GCTCATGCCT GTAATCCCAG CACTTTGGGA GGCTGAGGTG GGGGATCACA AGGTCAGGAG ATCGAGACCA TCCTGGCTAA CACGGTAAAA CCCAGTCTCT GCTTAAAAAA TACAAAAAAT TAGCCAGGCG TGGTGGTGGG TGCCTGTAGT CCCAGATACT TGGGAGGCTG AGGCAGGAGA ATGGCGTGAA CCCAGGAGGT GGAGCTTGCA GCGAGCTGAG ATTGTGCCAC TGCACTCCAG CCTGGGCGAC AGAGCAAGAC TCCATCAAAA AAAAAAACAA AAAAACCATT CTGGGGTCTG GAGAATGGTA GCCCTTACAG CACCACCAGG CAGTGCCCCA GTGGGGACTC TGTGTGGGGG CTCTGACCCC ACATTTCCCT TCTGCACGGC CCTAGTAGAG GTTCTCCATG AGGGTTCTAC CCCTGCAGCA AACTTCTGCC TGGACATCCA GGCATTTCCA TACATCCTCG GAAATCTAAG CCGCGGAGGT TCCCAAACTT CAATrCTTGA CTCCTGTGCA CCCACAGGCT CAATACCACA TGTAAGCCAC CAATGCTTGG TCAGGGCTTG AACCCTCTGA AGCAATGGCC TGAGCTGTAC GTTGACACCT TTTAGCCTAG ACATCTAGGA CACAGGGCAC CATGACCCGA AGCTTCATAA AGTGGGAGGG CCTTGGGACT AGCTGAGGAA ACCATTTIC CATCCTAGGC CTCCAGGCCT GTGATGGGAA GGGCAGCCAT GAAGGTGCCT GACATGCCCT GGAGACGTT TCCCCATrGT CTTGGTAACT AACATTCAGC TCCGTGTGCA GCACCAACTT ACTTATGCAA ATTCTGTCA CTGGT1TGAA TTTCTCCCCA GAAAACAGGA 7111C=I1 CTATTGCATC ATCATGCTGC AAATTTTCAA ACTTTATGC TATGCTTCCT GTTGAAGACT TTGCGGCTTA GAAA=TCTT CCCCCAGATA CCCAAAATTA TCTCTCTCAA GTTCAAAGTT CCACAGATAT CTAGGGGACA AAATGTTGCC AGTCTCTTTG CATAGCAAGA GTGACCTA CTCCAGTTCC CAACAAGTTT CTCATCTCCA TATGAGACCA TCTCAGCTTG GACTTAGTrG TCCATGTTAC TATCAACAT T7TGGTCAAAG CCATTCAACA AGTCTCTATG AAGTT1TCAAA CTTCCCCATG TTTCCTGTC TTCTAATAGC CCTCCAAATT TTTCCAACCT CTGTCTGTTA CCCAGTTCTA AAGTCACTTC TACATTG GGTATCTTTA CAGCAGTGGC ACTCCCCATG GTACTAATTT ACTGTATTAG TCTGTTCTCA TGCTGCTAAT AAAGACTTAC TCGAGACTGG GTAATTTATA, AAGAACAGAG GTTCAACTGG CTCACAGTTC AGCATGGCTG GGAGGCCTCA GGAAACTTAC AAACATGGTG GCAGCAAAGA GAAGTTCCAA GCAAAGAGGG AAAAGCCCCT TATAAAACCA TCAGATCTTG TGAGAATTCA CTATCATGAA AATAGCATGA GGGTAACTGC CCCCATGATT AATTTACCTC CCACAGGGTC CCTCCCATGA CAGGTGGGGA TTATGGGAAC TACAATTCAA GATGAGAT GGGTGGGGAC ACAGCCATAC CATGCCAGCT AGAGAGCCTT AAGAAAGTCA CCTAATCTCC ACAAATAAAA GGTCCTAT TTGTTCAACA AAAATAATGA CACCCCTT ATGGGATTTC TGTGAGGACA AATGATAACT AACATAGCCT TGCATAGTGT CTGGCACAAA ATAGCTACTC AAAAAATAAT AGAAACAACA TTTAAAAAAT GTAGACTTA ITlT-AGAG TTTATGTAC AAAGCAAAAT TGAGCAGAAT GTACAGAGAG TCCGTATA GCACTCCCTA CCCCCAAGCA CAGATAGCCT CCCCCAGTAT CAGCATCCCG CACCAGAGTG GTACATTTAT TATAACTGAT GAATCTATAT TGACGTGTCA TTTTCATCCA AAATCCATAG TTTATATTAG GGATGCCTCT TGGTGTTGTA CCTTCTATGG GTTTTGACAA ATGTATAATG ACATGTATTC ACCATTACAG TATCATAAAG AATAGTTTCA CTGTCCTAAA AATCTGAT CTTCTTCCTA TTCATCACTC WO 00/09525 PCT/US99/1 77-12 EPI-109 65 CCTCCCCATTr AATCCCTGAC AACTACTGCT AATITCCTG TCTCCATTGT 'IMGTC=r CCTGAATGTC ATATAG T~rA AATATACAGT ATGTAGGAT7 TTCAAACTGG 'T'7A TrCAC TTAGTAATAT GCA'TrrGATG TrCTCCATA TCITTCAAA GCT7CATAGT TCAATA1TA TAGAATrGAA TAATATTCCA TTGTCTGGAT GTACTACAGT rFrATGTATTC AT7CACCTAT CAAAGAACAC CTGGTTGCT TCCAAGTrrC AACAATCATG AGTAAAGCTG CTATAAACAT CTATGTACAT GTIT1TIGT GAAT7GAACA =IfCAGCT7 7TTAGCTCC A TCCTAGGA GTGCAATTGC TGGATTGTAT GATAAGGGTA TGTrAGTGT TGTAAGAAAC TGCCACGCTC TFTCCTAACTG GATGTACTGT 'IMGCAn7CT CACCAGCAAT GAAAGAGT7C CTGTTGCTCC ACATACTCAC CAGCATITGG TGTCGTCAAT GTITGAGCA ATAGCAT1T GATCTAACI TrCCTAGGTA TTCrTrGA AGGAAATAAT ATGACAGATA ATAGAGAAAG GATATACGAG GACAG TTCTG TCCI=ATI17 ATAGTCCATC ATI1AATGAA GGACTCTGTC CACACTTGGT ATI=AACT CTGATCCTCC TCTCCCATGA ACTCTGACAA TCTCCTAAAT CCCTGTI'GCT GGCACACATG GTTGTGTATC AGGCCCCCTG TGGTCTGTCT GAAGCATGGC TTTTF= ThITTIT= ~fTTMGAG ACGGAGTCTC GCTCTGTCGC CCAGGCTGGA GTGCAGTGGC GCGATCTCGG CTCACTGCAA GCTCCGCCTC CCGGGTI'CAC GCCATTCTCC TGCCTCAGCC TCCCGAGTAG CTGGGACTAC AGGCGCCCGC CACCACGCCT GGCrAA=FT TTGTATflT AGTAGAGGCG GGGTrCACT GTGTFAGCCA GGATGGTCTC GATCTCCTGA CC~rGTGATC CGCCCGCCTC TGCCTCCCAA AGTGCTGGGA TTACAGGCGT GAGCCACCGC GCCCGGCCTT TITrTITT ITfrlIT= 1T1GAGATGG AGTCTGTCAC TCTGTCACCC AGGCTGGTGC AGTGATGCAA TCITGGCTCA CTACAACCTC CATC1TCAG GITICAAGTGA TrTCTGCCACC TCAGCCTCCC AAGTACCTGG GATrACAGGT GCCCGCCACC ACACCCAGCT A TITITGT AITI=AGTA GAGACGTAGT T7CACCATGT TGGCCAGGCT GGTCTCA'ITC CTGACCTTGA GTGATCCACC TGCCTIGGCC TCCCAAAGTG CTGGGAT7AC AGGCATGGGT CATCACATGT GGCCTGAAGC ATGACTGTTG CTPAATCAT ATGAAATACT GCTCTGTATT G'FrATCTATT TGAAATGCCA CACCTCCTGA GCTAAAT7GC AAGCTITAT GGAGCACAAA CCATA'ITAT ATATA~rAGC ATGATACCAT GACACATATC AAAAGCTGT7 ATATATrGTT ACGTGAATITG A~r='~CTC AGTFTAAGAGG ACCTCTGTAG TAGCAC ATACCG'TAA FTITCA'ITr TGTGCCCAGC CCCTACTCTG TGAAAAATGA AATGAATCCT GTrATCATIIr CCCTCCCAGG CCITICTCC 'PTGTGGACAA TGTGTGGCTC AAGAGAAAAT TCAGTCAGTA AAn7ITrGFCA GTGCACAAAC TC1TATCAC CTCTCACTGT TCTCAAGTGA GATAGAACAG AACATCCATC CAGTGTC=A CAAA'ITGTCT GGTATATAGT AGGCACTCAA TAAATGTIT TTGAATAAAT GCATACATGA ATCCTATTCC TATATATAGT ATGGTAGACA GATCATrGAT ACCCAAAGAT GCCCAAATGC TGATCCCCAG AACTTGTGAA TATG~FrACAT T-FCATGTCAA AAGGGACTI GCTAATGTGA 'FAAGGATrC AGACC=TGG ATTGTAAGAT TATCCCGGAT TAACCAGGGC CAATCTAATC ACATGAGACC TrAAAAAAGC AGAAAACATJ? TCCCAGCTGG GT-rAGAGAGA GATGAGACAG AGTAAAAAGG AAAGAGA'ITC AGGGCATGAA AATGACTCTA CCCACTGTrG CTGGC'=GA AGATAGAGGA ACTAGGCCAC AAAACAAGGA GTATGAGTGG CCT-rAAGAAA TAGGAAAAAG CCCTCATCTG ACAGCCAGCT AGAAAGCAGT CCTCTGACCA CAAGAAAT7G GATTCrGCCA ACCACTCAAA TGAGCAAGGA AATGGATI'CT CCCCTAGAAC CrCCAGAAAG GAACACAGCT CTlGTAATGCC TrGA FTAG CCAGGTGAGA CCTGMTCAG ACTITGACC TATGGAAATA TAAGATAATA AAGTIT7ATT GTATGCTGCT AAATI7rGCGG TAG TrATrA CTGAAGCAAT GGAAAGCCAA TACAGACAGA ATATACAGAG AGAAAGAGAA TGAGTTC1T CCTGATAATT TGTAAATATT TGGGT=TCA CTGGACAAGC T7CACAGAGG ATrCACTGGT TCCCTAGCAA ACCAGCATGT CCAGTCCTGC AGCCTCC=~ TCTTAGGCCC AGCATATGTC AGCTGTGTGC ATAGAAAAAT CAAAGCAGGA CCCTGAGTAG 7TGGAAAGAA AAGATGGT-FG GAAATGGGTT GCACTrCAAG TGAGGAAACA AGAGGTAGGA GACCGGCATC TCTTCTCAT ATGTCCCAGG CTGACTC=G TGAGTrrGT"1r TCCCTTGGAG GCTATCGATG ACAGTCACAG TAACCTGATG GAACCTGGAT CATGATGAAA GAAGTAAGTG TCAATGGCTC CGACTrCCAA GGACTCTGAT GTCCCACAGC ACTAGCTAAA CAAAGCCAGT TGGAAATGAG CT-rAAATGGG GAATTTCCTG AATATATTCC CTATTGTFAG GAAGCCAGGT TGGCTrCCTT GCCTACAA'rr ATGCCAAGCA GTCACACTAT AGAGTCCCTA GGGACATGAT AT7AAGTGAT TCTITAACA CAAACAACTT AATAATCATr TATACTAATA GCAAAACGGC CAACGGCTGA TA77CCACT7 GAAGTAGAAT TGGCTATCCA ACTGGAAGAG AAGACAGGAA GACGTGATCT CCAGGGAGCC ACTAAAAGGA TTGGCACCrG CCTCTGGAT'T CCCCT=TCC TFrATAnTACC TCTCAGCACT GGCAGGCC17 TA'I=CAGGA TACAGT17CA CAAGTAT7AT GTCACGTCTC TGAGAATTAT GrrGGTAGAT A'I=GCTCCT CTGGCCAGAA AGACCTAGT7 TGGAGTCTGG AGTCATGAAG GTGACATACA TGTAGCTAGT GACATAAGTG TAGCTAGTAA AAATAGTGAG TAATGGCCCT GAAATTCTAT TGAATGCCCA AAGTGCTGAC CAGGAACAAG CATGCTCTAG =TATCTCAC AAGGAACITFG ACAA=F~CT TCAAAAATCC TAGTAGCTAA GA'ITCTrAG TAACAAAGCC ACTAAGGCAC AAT7ATGATT AA=TGACCC TTAGGTGACT 'ITAAGGACT ATTCTATAAA ATATTACAAC TAATAGTGGA TCCAAGCCAG CACACTCTGC TATATAAGAT TAATrGACAG TGTCCACACT GGTAAAATAA GTrGMTCAT AAATACATTA GAATrCA'M GCACTICTA CACAGCCCCA AGTCCAGAAC M~CCCCAGA ATAGGTCTAT G=T1GCAAT CTGCTACTCC ATACAGAGAT T7GAG ITCAC TTGGCAA=T AGTGCTG=T ATATGTGACC AGTTAGTCTG TITACT-rAT CTATGCCTrA AACATACTA TACTrACTAA CTCCAAGATG CCTGGTCTCA AC'FrGACAAA AATACCCCAA G'FrGGGAAAT CCTrATGTGA ATATGTAGAT AGTCACAAFT GCTGGTGAT GATGATCTGT CTITCCTGT AMrGAGAAA ATGGAGATAA AATGGACCAA TCCAAATAAT GGA'ITAAACA TGGGAATAGG TGAGAGAGAG AGAGGAATAC ATGGTGGCTC TCAGTGTCTG GCrrAGGCAG TAAACACTI CG7I'AATAAA GACGGAAAAT AAAAAAGGAA TAATTGGTGT CTAGGGGAAA ATAATGAGCT CAAGTITAA CACTCTGAGT TCCCGGATGT GAGACATCCA GGCGCA'TA TCCAAGAGGC AGTTGGAAGC AACG'TCCGG AGCTrAGGAG AGAGGCATGA CCAAAAGCTG GTGGGACTGT GAAAAGGTAT GGCCA FrCTG GAAAACTGTr TGGCAGTITC TrAGAAAAT7 AAACATGTAC TAACAACCCA GCAATTGTAC TC'ITGAGCAT ITrGTCCCAGA TAAATGAAAA AAAAAAAAAG CATTITIT ACACAAAAAC ATATACATGA AAGTTCATAG AAGTG~rA Fr CATAAAAAAC TGGAAAAAAC TGAGATGTCT TFA'ITGAGTG AATGCTrAGG CAAACGGTGG TCTATCCATA CAATGGAAT7 ATGCTrAGCA ATAAAGAGAA AAGAACT'F GATACATGCA ATAACACAGA TGAATCTCAA AGGAATTAAT GCTGAGTGGG AAAAAAAGCA CATCTCAAAA TGGTATATAC TGTACTAT17 TATIACTA ACATITAAA AATAGCAAAA TCATAGAGAT GGAGAACAGA YFAATGGGTA CTGTGTITG GGATGGGGAG TGAGAAAAGG GTAAGGTGTA AATATAAAGG GGTAGCACAA AAGAGCCTG TGGTTGAAGG ATrC7ATGTC 'ITGGTrGTAG TCGTGAT7GC AGGAATCTAC ATGTGATAAA AT7GTATGGG TCTACATACG CATACACACA AGAGCATATA AAACTGGTGA CATGTGAAGA AGCTCCGCAC ATTGTGCCAA CATCAGTATC GTAGTr7CAA TATCAGACTA CAGTTATACA AAACATTGTC AT7GAGGGAA ACTGGGTAAA GGGAACACAG GACATIGGC ATATATITF GCAA FITCCT GTGAATCCGT AA'ITATIAA AAATAACAGA TATACTACAT ATCAAAAATT TAATGTCATA AAGT7GATGA G ITTACCTAG TGGATAG=~ TGTTAATATC TGCTATAAGA CTACTGAAAA TGACAG F7AT GCAAGTATAA GCTCAGAGAA CI=CCrCCC CCTTCGTAAA TGAAATGAGC AAAAGAAATG AAACAGGAAA GGCAAGCAGT ACTGAAAACA GGGAAGGGCT C17CCCCATA TAACTATATC TGCGAC=CA ACAGCTATTC ATCCAGAAAC ACAGCCTC= GCGCTAAGAG GAAACTIGG ATAACAATAT GTITCACTC TCCAAGAGAG AAAATGGATA GATTAATI= TAAGAAAAAA AAAAAAACCT CACCAAITTC ATGJrGTGGC '1TGCAC=tI AATCCCAGCT ACCTACAAGG CTGAGGTGAG AGGCTrACTT GAGCCCAGGA GTTCAAGGCT GCAATGAGCT WO 00/09525 PCTIUS99/1 7712 EPI-109 66 ATGATTGATr GTGCTATCGC ACTCCAACCT GGAGTACTAA GCTAAGAGCT AAGAACACAG CTGAGAGCGG AGAAGAAACA AACAAATCTG ACCAATAACC CCCACTCCCC TCATTIACT GGAGTGAGCT GAGACTGCTG GCAAACATGG CC'=GACCT AGCCTGAACT GTAGCAAAAG TCATCAGATA TI=CCACC AATCAACAGA CAGAAGTGGG GAGAAAACAA TCGTAGTrCA TAACTACAAC AAGCAGATAA ACGAAGGCCA TGGTGAGGGA TGGAAGACAT TGTGATATAT CAAAGGCAGG CTCATrTAAA ACTCAACCCA AATrCCAAAC AAAATATATA ATTGAATATG TATTAATGCC AAAGGAGCTT GAGTGAGCTT TAGCACAAAC CCCGCCCTCC AGCCCCCACC CAAAAAAATC AC1TCTGTTCT CTCCCCATTC TITGATAGGC ATACTTGCTG TICrTCACA GCCAAGGTAC AGAGGGGACT TAGAGGAACT AGAACTCTAA TACACTGCTA GCAGGAATGT AAAATGAAGC ATCTACTrCA GAAAACCATr 'FrATCAGMF CTAGAAAGTT AAACATAGAC CCACCATGCA GCCCAGCCAC TCTACTCCTA AGTA'IMACA CAAGAGAAAT GAAAACGTGT CCCCACACAG TrGTATTrAA AGGTGATGGT TAGCCTTGTG TGTCAACTrG GCTAGGCTAT AATACCCAGT TACTGAATCA AATAGTAATC TAGGTGCATC TGTGAAGGTA TITGTAGAT GTGG11rAACA GCTACAATCT GTTGACTTCA AGTAAAGGAG A'FrGCTCT7G ATAGTATGGG TGGGCTTCAT CCAATCAATI' GAAGGCCTI'A AGAGCAAAAA GTAAGGM~C CCGGAGAGAA AGAAATrCTG CCTCAAGACT GCAGCCTCAA CTCCTGCCTG AGTI1rCCAGT CAGCCAGCCA GCCTAAAGAT 'ITGCTAGGCA TlATAATCAC ATCAGCTAAT TrCTrAAAAT AAACCTCTI ATATATATTG ATACAATGAA TGGTTATAGC AGCCTTAfr GTAATAGCCA CAAACTGGAA ACAACCTAAA TGTCCPTCAA TAAGTGAATA CATAAACAAA 'ITGTGGTATA TCCACAA=~ TTACGCAGCA GTAAAAAGGA ATAAATGGTI' GAATAAGGAA TAAACACATA ACAAGGATGA ACCIAAAAC CGTAAGGCTG AATGGAAAAA GTCAGACAAA ACTAATACAT ACTGAATAAT TCCA FfATA TfGAAGTTCT AGAAAATGAG GACTAAC~rA TAGTAACAAA AAGCAGAAAA ATITGCCCA CTGGTGATGG AGGGGGCGCA GGTA'ITGTAG AGTATCTGAG AAAGGACAAC TGGATAAAAG GGGGCACAAG AAAACITIG AGGGTGATTG ATATGTrCAT TATCT7GTGG CATGGMIICA TAGGTGCATA CATATGTCAA AACATCAAGT TATACAC1T TAAAATGTTC AGTTACTGT ATATCTKI1rA TAC=CAGTA GAGAGGAAGG AAGAAAGTGG GCAGGGTGGG GGAGAGGAAA GGAAACGAGG GAGGAAAGGC CCTAATAGGA AGGATITGG AGT1TAGA IT TrAAAATGAT AAAGGATGTT TGACACTCTA GGCATATGAC GAATATAGGA TrTATGAGTCC ACAAAAACCA CCAGGAAGTC ATGTATGTr7 ATACTI=AA GTGAAGGATC AGTGGATrAT CAACTCCCTA ATGCI=GCC TCTCTATGAC TGGCTGCTGT CCTrCTCATC CCAATACTCC TrCCAAAGCC C=TGCTTAA ATGTAAGCCT TCTTCCTCC MTCAACACA TCCTGCAITC CGTGACAAAA TAAG=IrCC flAAACAGAA TGTACAGCAT AATI71GTA CAATI'AAAAA ThIIGGCCA GGTGTGATGA CTCATGCCTG TAATCCCAGC AA'ITGGGAG GCCGAGATGT GTGGA'ITACC TGAGGTCAGG AGTTCGAGAC CAGCCTGGCC AACATGGTGA AACCCTGTCT CTACTAAAAA TACAAAAATFI AGCTGAGTGT AGTGTGGCAG GTACCTGTAA TCCCAGCTAC TCAGGAAGCT GAGGCAGGAG AATCGCT7GA ACCTGGGAGG TGGAGGTTGC TGTGAGCAGA GATCAGACTA 7FGCATTCTA GGCTAGGAGA CAGAGTGAGA CTCGGTCCCC AAAAAAAAAC ACATITITI TI7AATGMIC CTCMVGCCT GTAGGAAAAA GGCTCTGACT CCTTAGCCTG GGCATCAGAG cTCTATCTAA ATGGACTIA ACCTGA'II GTGGCACTAA YTCCAT7GCA GTACTTGTCC GCTCACTGGC CTGTGCCTCT CTGCCACTAT T=TGGAATA ATGTCCTCTC TCCATCT7GT TTACTCAACT ATATCCAACC TCTAAGGCTG TGCTCCTACA AAGCCTCCCC TGGCTACTrC AGCCCACAGA GATAInrAAC TGCTCTGCAG TTCAGGACAT TCTTCTGACT C'=AAATCA CNITrACT7A TATATGATCT TGTGATATI TGTTGACG TGMTACT= AA=TCTTC CATAACCTAT TCATTCAACA AACTCAACAA TTAMIATTA AATGCCAAGT TAGAAAAATA TrATTGAMT TATATAGATT1 ATAGATATGT T1TGAAA II1 ATITGGCAAT CTGCAAGTAG AAAAATAATT ATAATGTGGT ATATCTGTGA TAGAAGTATf AGTGCAGAGA CCATGGGGAA CATAATCCAG CCTGGAAGTT CAGGAGAGAT ACGTGGAAGA AAGGACGTCA GAGCCTF=T CCTACAGGCA TGGAAGAAAC ATTAAAAAAA ATITFIT1T] 7rGAGATGGA GTCTCACTCT GTCTCCCAGC V1TAGACTGTG GTGGTGCGAT CTCTGCTCAC TGCAACCTCT GTCTCCCGGG TTCAAGTGAT TCTCCTGCCT CAGC'ITCCCA AGTAGCTGGG ATTACAGGTA CCTGCCACAC ATGGATGATA AATATGATCA TA'ITTG TTCTI=CCr CCTCAGT7GT CTrCCCTGAA GAAAGGAATG CCTITATAG ATGACAAACT CCCATTCTCA AGAACAAGGA T1TFGACCA ATITAAT7A ATCAGATGTC TGGC1TGAC CTAGAAACAC AGTCACGAAA CTTGGTGA17 AGAGACCAAT TCCCAAACAT GAGCAMTCT TAGGAAACAC AGTAAAGATC TGAGAGACCC AAGAGCAGAA GGGCGAGAAA CCAAAAGCCA TCAG1TTGCA TAGGAAACAC CTTG717AGC CTAATCITI TA7II=ATr ACTCTATTAG TCACTACAAC TAFI=CTGA TrGCTATGGT GATAGATGGT TTAAAACAAG CCTTCATI'AA GAAT7GTCAC ACCATGGTCT CAGTCAAAAA CACCAACA F7 'IATTGGTA 'FrGACAAT7A TGGGAATATC CAAT17CCAAG AAGACAAGGA GACCTCTGAA CTICTAAAT GAAGACTCCA ATCTTCCTGA TCTGATGGGA AGCAGCTTGG CAAGATTACC AACCACCACC ACAGAGAGTG GACTCTAAGC TAAGACTrAA AAGATAAGTA GAAATTATCC AGGTAAAGAT GTGTACAGAG AAGGAAGTAC ATCCAGGGGA AAAGAACAAT ACGTGCAAAA GTACGGAAAT GGTAAAAAGT AATACTACAT AGTCAAAGCC AAGCAGAGTrT CAGAAGGGAT CTGGTGGTGA AAAATACGGC TAGAGAAAGC AGCAAGGATT GGCITCTAAA ACCTATGTAG TATCTTGGAC CT-rACCCTAA ATGTAATGAG AAGC~rCTAA AGAATCITC AMTATTCAT TCATrGAACA AATA2TIGA GGCITCTGT GAAGAACATC ATTCTAAGTA GTAAAGATAC AGCAGTGAAT AGGACACATA AAATCCTAGA TCTCACAGAA TTGACATTCC AGAGAGGGAA AGGTAGACAA TAAATACATA AACAAATCAT TrAACAAGAT GA'IMCAGAC AATGGTACGT ACTGTGAAAA AAATGAAACA AGGTAATGGA CAGCGAAAAG GCACTGGAAG GAAGCCTGCT TACCTIGCA TGGT7AGAAA AGATCTCTCT AAGAAAGAGA CCACATGTGA GCTGCGACCT GAAGGATACC GAGAAGCTAG GTGTGCAAAG ATGTGGGGAC AGAACFI=G GACTGAATAG CAAATACAAA TGCCCTGGG TGCAAGC1T GCCrG~ITCAA GGACCAAAAA GAAGGCCAGT GTGCCTGCAG CATACTAAGC ACAGAGGAAA ACACTG TAT ATGCTGAGAT TGGAATlATA AGTAGAGCCA GATAATATAG TCTCTATAG GTCATAATAA GGCAACCAGA l=rAFCCA AGAGGA-mA AAAATCACTG GAGG=1IGC ACTAGGGTGA GAGGTGTGAT TrGTATFF AAAAGATAAT TCTGGAGAAT TAACTATAAT GAGGTAGGAG TAAACTAAGT TAGGGGCTAT ITCAGTGGCT CAGACAAGAG ATAATGGTAG CTTAGACTAG GATAGTAGTC GTAGAAATAA ATAAAAGTGG CACTCTACTr TGGGGGTAGA GTCTATAATA GGMI1GGMfl ATGGATCATA TATGAGAGTA AAAAAAAGAA AATAAATTAA TAATGGTrCC TAGGIMGTA CCTGAGCAAC TGAATAAATG GGTGCTGTGA ATTGAGATAA AGGAGATTGA GAATCACAGG =T1GI1TG CAAAT1FAA'11 TTGAGAGGCT TATTAGACAT CCCAGTGGAG AMIICAGGTG AGTGGAGCCC ATTGAAAGGT AAGGGACAGG GTCAGGTGTG GTAGGTCAGG CCTGTGATCC CAGGA=F1G GAAGGCCAAG GCAGACAGAT CAGTrGAGCT CAGGAG T~rG AGACCAGCCT GGGCAACATG GGAAAACCCT GTCTCTACAA AATATGCAAA ATA'FrACCTG GGCATGGTGG CATATGACTG TGGTCCAAGC CAC17GGGGG GCTGAGATGG GAGGATCACT TGAGTACAGG AGGCGGAGGT TGCAGTGAGC CAAGATCTCG CCACTGCAAA CCAGCMrAGG TGACAGAGTG AGAACCTGTC TCAATAAATA AATAAGAAAC GTAAGGGAAA AGGAAATTAA TCTGATCATT GGCAAATGCA TAGTA'IMAA AGCCAGGGGA GTAGATGAGA TACTCAAAGT AGGTGAAGAT AAGGAGGCAA TGAAGGCCTA GGACTCTGGT GTACATIAG ATGGTI'ATAA GAGGAATAGA AACTGGCAAA ATAAGTAACA CTGAGCACCC AATGAGGTGG AGAGGAAAGC CAGGAGATGA AGCATCATAG AAGGCAAGAG AAGAAGGGTG TCAAAGAGGC GAGGCAGTCA TCAAC'ICTG GGCAGTCAAA TAATATAAGG ACAGAAAAGT GACCATT1GGA ITI'GGAAATA TGATGAGCAC FITGAGTGGA GTGTTGAGAC AGAAGACCAA 'ITAGAGTAGA WO 00/09525 PCT/US99/1 7712 bpl-109 67 TrGAGGAGAT AACGAGAAAT GAGAAAATGT AACCTGCAAG CACAGACAAT TCTrGAGAGA CTITCTGTG AAAGGAAACA GACACAGAGT CTTAGCATGT CTTGTCFIC TATGGGAAAT GTAAATAG~r TGAGATCAGG GATAGTA FF TA TrCTGCTIT TrGTACCTC TACATTACCT AGCATAGAGC TAGCTAATGT GCACTTAAGT ATGTTCTCAA 'TTrATCGC CTGAATGACT GGATGGGTGA AAGAATGGAT GGATGGATGG ATGGATGGAT GGAAGGATGG ATGGATGGAT GGAAGACIC TGAM~GCCA AGAAGAGGAT ACTGGTAGCA GAAATAAAAA CAGCACTGGA GAAAGAAGAG nI7AGA=f~ TAT1~T=GXG TGTCAG FrAG ACAGGAAAGT AAGACATTAG AAGAGTCC11? AGATAAMA TGTAATTGTT CACTT1AGGAT =IIAAATGT GATCACTGAT ATTGGACATG TlCCAGTGA AGCA T1TG GTG'ITCACT GG'TGAAGTT AATAACTGTA AAANFFnITC CCGYI7CAGGA CAGAAAAACA GAAAACTTGA AGCTCCTATT AGAAAGTITCA AGATTCTCTG GGGflCI1AG GA'1ACTGT TCCCAAAACT CTGTCAAGAA CAAGAAAATG ACCTGTATAC T-rAACTGGTC TAGGCAACAG TGGAAAGACA AT7CTCAGAG AAGA'T7GTT TTAAGAAGAC ACI=CCATA Gc3AATCAAAC AATAGCITC AGTGACTAAC ATGGTAAGAC ACAGGGTGTr AGCTCI=CC 'FrCCAACCTC ATGGCTGTTG TACCTTACCT TFFCGACCCCG TGTTCCTGAA ATrGTTAAAT TCATAAAC7T ACCAAGGACT AACCAGCCTC TGGGGAATTG CTGTATACTT AGCAAACT7A CAATGGACAT ATFITATAAGC CATAATGATA ACTGACTAAT AGGAAATACC CTCAACTGAA AATGAGAGAT CATCA'TGC AAATGAGTTC CCTTGCCCAG GCAACTACTG GGGAAAATGT CATGCAAGCA AAATTAATCT 7rGAAATCCT CCTIICCAT 'FTTGTGTC TFTCCTITCC ATAGGCACCA GAAATATCAT GGTGCCTGGA TCTCATCTCT ACAGAAAAAA AAAGTGAT GATAAACTGA n7TATA~rGT GTCCAAATGT GATTGTATFT TCAAAGATAA CCTAAGGGGA GAATGCTGTC TGGCCCAACA GCAGGCTCTC GACTrCATTr CAGACACTGT GGCCAATGGC TGGGAAACAG GTATGAACAG TAGG T7CTG AGTCCCCTGG AAFTAflCCA FITATGTAGC CACCTCCATG ACAGGAAGCC TCCCTACTCT TACT7CCCAG TTrTrCATr CATGGCACCA GGTTGCAGAT TAAAAM~GC TCAGTGACCT TTTATCTAAT AATGTGTTAC C'TT=CTCT TAAAAAGTAC AAGGGACAAA TGCTCATGGT ATACiT=lAG GAGAT7GTGG CTCTCTAITA ACAGTA'TrA TFCAACAAAC A'TFTAFTGAG CAITIATATG TGCATCATGC TAGGGACTGG AACCTAGTAA GTGTAGCACA TATrA'IMCA TAATCCTC ACAACAAACC CATGAGGTlG GTITATGAT CCCAATTIT CAGAAGAAGA AACTGATATr CAGAACCAGT TAACTAACTG GT7CAAGGTC ATGCAATrC TAAGATACAG AACCAAGAGT CAAAGACATG A=F~AAACC AAAGCTIT= CTGCTACTCC ACAI7GCTrC CCTAGGTGAG ATCTGAGGCA 'TCCGCGAAA AGAGAAGGGT CATAAAGCCA AGGGAAGACA AGCTrAGGAA AAAAAAGGGA AATGTCCTAA ATAAACAGCT 'FrCCTA'FTrA CCAGAAACCA CTAGTITAAA AATATAATGG GAAAAATCCT ATTCAC=rA ACAATGTFTAA AAAAAAAAAA GATAGAAGAA ACATAGGGAT AAAC'ITAACA CA'TTFGTAGG ATATGTAAAG AAACTAAAAG ATGTTAATAA TGGCCTAAAG AAAAAAAAAC 'FrACATGTAT GGGGAGATAG ACCATC'IAC TGGATTCTAA TA'I=AATAG TCTAGGTGT7 CCAT7CTCA CCAAA'ITAAT GTATACATr AATACAATGT CAAACGAAAT ATCTTAGGAA TrGCT-rACAA ATTGTCAGAT AATTACAAAG TI7rACCTGGG AAATATAAGC ATATATGAAG AGTGAATGGG ACCCCACCAC TCCCCCCAAA ACAAAAAAGG TCTGAAAAGG ACAGAAATCA AGGAGAGTCT TGCCTGCCAG ATACAAAATT CTATrATAAA GGTGTATrGA TGAAAACAAT TTAATACTAG TGTAGCAATA GGCAGCAAAG CAATGAAACA GCATAAAAAG ACCAGAACTA TACCTAATFA TGATGAAGAT TrAAGGTATG ATAAACATGA CATAATrCAA ATCAGCAGAA A'TTGGCATAG ATAGGGTrAA GACAAATAGC TAATCATFAG AGGGGAGGAA GGAAAGGAGG GAGGATAAAA TTAGG~rCCT GCCT1CATCT TACATTAAAA TAAATTCCAG ATGTATTACA 'IT1AAA'1fI TTAAAAAAA GAAACCACAA AATAC'TGAA GAAAATATAA GTTGTTATAT AGTCTITGA TGGGAA=rr TT1TFIC AGAGACAGGG TCTTGCTCTG TCACCTAGCC TAGAGTGCAA TGGCATGATC ATGGCTCACT GCAGCCTI'GA ACTCCTGGGC TCAAGTGATC CTCCCAGCTC AGCCCCCCAG GTAGCAGGAA CTACAGGCAT GCGACACCCC ATCCAACTA 'ITFI=AT7 717GTAGAGA CAGGGGTCTT GCI=GMTC CCAGGCTI'AT CTCGAA=TC TGCCTTCAAG CACCTCAGCC TCCCAAAGAG CTGGGCTGAT GGGACA'TrT TTAACATAGT GCCACATTAC CATAAATGAA AAGCTrGTAA AATACTAAT MTAAAACTA ATATATATCA GAAATTA TAAACAAAGT TAAAAAGCAA ACACAAAAAA FIGTAGCAC TTATGACAAA TATATGTATA TATATGAATA CAAAAAGAGC C1TACAAAA CAGTAAGAAA ACAATGAATA CTCCCAATGG AGTATTCAAA ACTAAACTGC TAAAAGCAAT TCAAAACAAA AAACATAAAC TATGCATATA TGTATGTGAA AAAGTITAAC CTTATCAAAG AAGTAAACTC TCAAAGAAAT AAACATCAAA TAAGGAAATA GCCTITCCC ACAAATAACC AAAATCTGTA AGAATACTGA GCTGCGAATG TFITCAGAAAA AAAAAAAAAT CATACACCTA GTTCGGCATG TAATTAATAT AGATCAGAAC ACT=AAAAA TA'FITATAGG CCAGGCACGG TGGCTCATGC CTATAATCCC AGCA='~GG GAGGCCAAGG CGGGTGGATC ACCTGAAGTC AGGAGTTGA GACCATCCTG ACCAACATGG TGAAACCCTG TCTCTACTAA AAATACAAAA ACTAGCCAGG CATGTTGGCG TATGCTGGTA ATCCTGGCTA CTCGGGAGGC TGAGGCAGGA GAATITGCYI'G AACCCAGGAG GTGGAGGTTG CAGTGAGCTG ACATT1GTGCC ACTGTACTCC AGCCTGGGCA ACAAGAGCAA AACTCTGTCT CAAAAAATAA TAATAAATAA AAATAAAATA TTTATATACT CTGACCCATC AA T7GTCCA GCATAATrAG GCATGTGTAC AAGGG'IMAC ACACAAGAAT GCCTMTTGCA ATATTGUIT TAATGCTAAA AAAAATrGGG GAAAATGCTr TAAAAATATA GATTAAGACT GTACA'11GTG GTACAGTCAT ATAATCAATA GTATACAGCT ATITTA'1Tr TrCAGCCACT GTCCAAAATA TAGCCTGGCC TAACAACA17 CTGTrAGGAT ACGCAAGCAC CGTGAGGAGA TCAGCrATAA AGTATCAGTG 'I=CACACCA CTGCTCCTI GCTAATAACC "T7CAATGGCT TITAAAGAAG TAAAAAACAA AGGCAAAA F[ CCTrAGTCAG CCCTlAAGAC TCTC7TrfAC TTAGCTCAAA CTACCC FI= CAACAACACT GCCCTAACCA GGATGAGTTT InrGCCCCCC TGGAGTACAT TCAGCC=rC CTTATCAAAC CTTCCTIAA ATAAGTATCT TCTCCAGGAC CAC=CACT7 TCT7CCCCAA T'1TAGCA'I= TCTATATCTC CAGGCCTACC TCTATAAAGC CTGTCCTAAC CACTCAAACC CTAGC'TTT CTCTGAACTG CTAGAAATAT TITCTCTCA TTGGCCA IT AGGTAAAAAG GTflTACTG IAT-rACCT ACTCAATAAA AA= =T~F =IrGAGACA AGGTCT7ACT CTGTCGCCTA GAATGGGGGG AAGTGGTGTG ATCACAACTC ACTGCAG=~ CTACCTCCCA GCTCAACAGT CCTCCCACCT CAGCCTAGTG AGTAGCTGTG ACTACAGGCA TGTGCCACCA TACCCCACTA CT!TICAT17 TrrA'TTr GTGAGATGGA ATCTCACTAT G TACCCAGG CTGGTCTGCT GATCTCAAfl GATCCTCCCA CTGTGGCCTC CCAAAATGCT GGGAI7ACAG GCATGAGCCA CAATATCTGG CCCCAGTAAG CTITAAGGC CATTAACATG AGGAACAGTG TTC]TT1ACAC TA7MTATCA GCTAGGGC= TGCATGGAGT AGGAG'IMAG TAAATGCGGT TGATGGGTTA ATCAATGTGT GAAAATATTC AGAGCCACCA AAAACAGATA TTATGTCTAT TCTCATCAAC AATCAAAA'Fr GAGTAAACAG CCA=IrCTA ATACAGGAAA CCACAAAACA TTGAATGGTG ACATTAAAAA ATCCCCCAG CAGGAGCCAA CCAATTIT CATCCTGATC CAAGTTAGCA AACTGCAAAA GATAGGAAGC ACTAATGAGT GGAAAITGA GTAGAAGCAT T7C7TATGAA GGCTGTCTTG ACTGGATCAC ATflTAT7G CTGTTGGAGG TGCCAAATGT GTGTG7I17AT GCTAATCCTC CACCTCAGGC AACACACAGT CAAGGATCCT ACCAAGTGTT7 ACCGTCAAGT GTCTGT7GGC AGCTCAAGGC CCCAGCGT7G T7CCCTrGCA CTAGGGAAAA GACATATrCC AGGTACAAGT ACTCCCAC'IT TGATGCTACA GAGGAGTT1GC TGAAC'T!GT GTCAflAATC TCT=~CG'Fr AGATCCCAAC CCTG'TI7AAA TCCCACTATC TGCCTACTCT GGGT=TCAC CAA'I=ACTA GATCATAGTT GGAGAAAATC TACAAAGCCT TGCTCCC'IT AGATTAAAC AGGTCTCCGT T-rAAATTTAG AATTGCTAAC TTCAAGCGGG CCCTTATGCG ACAGTATGCC TGTCAGTCAT ACTACAMFC CTCAA'F7CCA TrCATGTGAC TGCTCCATAC CCTrCCCTCT CTCTI'CATAC WO 00/09525 PCTIUS99/1 77-12 bI'I-109 68 TACTATTATC TC'ITCCCCCC TCCCTCA'= TAACTGATG ATCT1TGTITC CTAT1rCTCT GAGAAAATAG AAGCCATCAA AAGAGAGTI CCACAAACTC CTACTGCCT ATCTAGCCCT GTACCATATA CT=GCATFF7 CCTCTCATTA CCATGGATGT ACTGCCTATC TGTGC=CTA TCTAAGGCTA ACCCTCCAC 17CAGTT=G AATATIATCA GCTCTACCA ACTCAAGGCC A FTGCTCTAG CAATTCTCTC AT7CTCTCTC A=M~r~CC ATCAAGTIT CCT=CTFC AAT-FAACAGA GTAGCTCCTA AAGGGAAAAA AAAGTCTCT 'IITCAATGC TCATCATCAC TGGCCATCAG AGAAATGCAA ATCAAAACCA CAATGAGATA TCATCTCACA CCAGTrAGAA TGGCAATCAT TAAAAAGTCA GGAAACAACA GGTGCTGGAG AGc3ATGTGGA GAAATAGGAA CACTI=ACA CTGT7GGTGC1 GACTGTAAAC TAGflCAACC ATTrGTGGAAG ACAGTGTGGC GATTCCTCAG GGATCTAGAA TTAGAAATAC CA'ITGACCC AGCCATCCCA YrACTGGGTA TATACCCAAA GGATTATAAA CAATGCTGCT ATAAAGACAC ATGCACACGT ATG 1TATrG TGGCACTACT CACAATAGCA AAGACTrGGA ACCAACCCAA ACGTCCAACA ATGATAGACT GGATrAAGAA AATGTGGCAC ATATACACCA TGGAATACTA TGCAGCCATA AAAAATGATG AGT7CATGTC CTIGTAGGG ACATGGAGGA AGCTGGAAAC CATCACTCTC AGCAAACTAT CACAAGGACA AAAAACCAAA CACTGCATGT TCTCACTCAT AGGTGGGAAT TGAACAATGA GAACACTTGG ACACAGGAAG1 GGGAACATCA CCCACTGGGG CCTGT7GTGG GATGAGGGGA GTGGGGAGGG ATAGCAT7AG GAGATATACC TAATGTTAAA TGATGAGrrA ATGGGTGCAG CACACCAACA TAGCACATGT ATACATATGT AACAAACCTG CACGTTGTGC ACATGTACCC TAAAA=TAA AGTATAATAA AAAAATATAT ATATATATAT AAAACAACTA AAAATAAATC TTCTTITCT GCAGGATCAG TCCATCACCA CACACACAGG CTGTGTIIA TG TGTTCCC CAGCTTAAGA GATCGTTCTC CAGATCCCAC TGCTCCTTCC AGTrGTCACC TCAGTTCTCC AC7FCTITP GCTGATAAAC TACTCTAACT AGTrACATAT GATCTGTC CCCAGGTCCC CTCCCTCAGT TG=IGcAAC ATAATCAMT ATATCA'ITA TCATITCAC TCTAATrGCA CAACCAAAAA CTCCCTITP =IJAGATGG AGTCTCACTC TGTCACCTAG GCTGGAGTGC AGTGGCATGA TCTCGGCTCA CTCCAACCTC CGCCTCACGG GTTCAAGTGA TCCCCCTGCC 'I1AGCCTCCT GAATAGCTGG GArrATACAC ATGCACCACC ACACCTGGCT AAT7GC1TG TI=GITrTG TGTGTGTGTG TGT1TIT1T 'TTFIGGA CAGAGTCTCA CTCTGT7GCC CAGGCTAGAC TGCAGTGGCA TGATCTCAGC TCACTGCAAC CTCCACCTCC TGGGTTCAAG CGATT1CTCCT GCCTCAGCCT CCCGAGTAGC TGGGACTACA GGCATGCACC ACCATGCCAG GCTAATI= TTGTATITC AGTAGAGACC AGGTCACC ATGTrGGTCA GGCTGGTCT GAACTCCTGA CCTCAAATGA TCTGCGCACC TGGACCTCCC AAAGTGCTGG GATTACAGAC TTGAGCTACT GCGCCGGGCT ATI=GTGTT IrrAGTAAAG ACGGGGM~C ACCATGT7GT CCAGGCTGGT CTCAAACTCC TGACCTCAAG TGATCCGCTC GCCTCAGGCC CTCAAAGTGC TGGGATrACA GGAGTGAGCC ACCATGCCTG GCCATAAAAC TGCCC'I=GT TAATATGACT GTI'GGCCTGC ACAT7GTCAA ATCCAGTGGC AT-rCATCrA CTCGGCCAAC CTACGGCA'Fr TGACACTrGTC TGTCI=CCT TCTGTTCCTC TATCTG'IMC CAGTATACTG GCCTGGC1T C7II=ACCT CTI=ATATG CTCT7CCAGT CTCAGGCTCC T7TGGGGATT TGAAGGTATG TFrGCATI=G CTAT-rCAATG AATAATGACA AGTAATGATC ACFI7AAGACA TEAAGTGGTC AGTTCCITA CTAGGATAAA AATAA=FTC F7CCCAACAT GGGGCATAT7 CCA'IMCCAG TCTGACTGT7 CTGTGTAATC ITrrGTATrCC TrGGCAGCCC GTI=ATATC AGTrCATCTA CTGTGCAGGA AATTrGGACAA ACATrTGCAC TGGTATAACC AAATACAGTT GAACTITGG CTTGACTCTr AGCTGAACTC ACCAAAAATA A'I~rGTAA GAGACTGAGA CGTCTACGAG TAGGTITTC AGAATrAGTA AACATAAATC AAGGATACAC AGGTAGA717r GAATTCAGA TAAACAACAA ATACIT=T AGTATGTCTA CTGAAATATr TGTATCTTAT CTGGCAATTC TACCTGGTAC AGAACTAATC CATCTC=G AAAGATCTfG ACTCTGTAAT AAGTr(C'I I G GTGATGGAAG GGAGGTA IM CrGTAATrAG AGTCACTGTC 'ITCCTCCCAG TITITATCC TGGCCCAGAT CTGCAATGAA CACACGACAG AATCCAGGGG GGATGAAGAT GGGTGCT=G CAGGAAAAAA AAATTAAAAA CATCTGAAAA AGCTITGTA CTAAAAGAAT GTGATCTAAA AAAGAAAGCA GGAGAACTI CTGTCTGCAC TITACATCAG AACAACCTG GCGTCTAGAA GCTGTGCCCT GTGGGAAGTG GTGGTGCT7G GTAAGAGATG CCAGGACCAG TGGTACCCAC TGGGAGCACT GCCAATACCC AGCAAGGAGC ATGGGTGCAC AGTAAGGCAT TGCACTGTGA TFCAGCATAA AATAACAATA AGGGAACGTC ACGGAGAAAA GGCCAGACTr CC1TGMTA GAATGTGGGA AATGTCTrCT GAAAAATGGT AGTAAAAAAG CATGCTTGGA TGGTCCACTC CAGGCAAAAC TGACTAATCG GGGGTCAGGG ATACAACCCC TGCATCATAT GTT7GTCT GTGGGCTGA CATGAGGTTC ACTGTGACCA CTGTGG'1A ACCCCATAGT CTCCTGGAAA TACAGCCAGG TCAAGAGAGC TCCACATAAA ACATAATCAA AAAAATAAAC TCAAGTITCC ACTGATCAGC =TICACAAC TC-FATCC= TCACTAAC7rr TGGAGCAAGA 7ITGAGAA'Fr GGATGGCTAT 7rGAGGGCTA 1T1CTGCGCT 'ITAGTrCAAT GI=rGTCT FrC'TrA GAGAACTATG GFTITTAT7 ATAMFACAC MTAAGT7CT AGGGTACATG TGCACAACGT GCAGA T7GT TACACAGGTA TAAATGTGCC ATGTTIGG'FM GCTGCACCCA TCAACTCGTC A'IMACATrA GGTATrCC CTAATGCTAT CCCTCCCCCA GTCCCCCACC CCCCGACAGG CCCTGGTGTG TGATGITCCC CT7CCTGTGT CCAAGTGTTC TG~ITATGTG ATAGATTACG MT7rGATT TGTGTATG Tr GAACCAGCCT TGCATCACAG TCACITGC= ACAAGAAACA AACACTrCAC AGATGGATCA TTATGTGTGA TAAGTGAAAT CCAAGGAMT ATGCTCAGAG GTGGGCTTAA CAGGTAGGAA GAGCAGTATT TTCC-17CAAC CATGAGTGTA TGCAGGTIT TCFIr=r TTI7GAGATGG AGTCTCACTC TI=ACCCAG GCTGGCGCGC AGTGGTGCGA TCT7GGCTCA CTGTAACCTC TGCCACCTGG GTTCAAGCAA. TrC'rCCTGCC TCAGCCTCCC AAGTGGCTGG GA'ITACAGGC ACCTGCCACT GTCTCCGGCT AA TITGTC ITITAGTAG AGATGGGGTT TCACCAT=~ GGCCAGC=7 GTCTrGAACT CCTGACCTCA TGAATCATCC 'rCTCAGCCT CCCAAAGTGC TGGGATI'ACA GGCATGAGCC ACTGCGCCCA GCCCACAGGT ITICAAAGA CTAAACTAA AAAAAAAAAA AAAATITCCC AATGAAATAT AAAACTAAAG TGCTAAACTG TGATAGACTG =IrACAAGA ATGCCAGTTr TCACAAGTGT CTATAGAACA TGTAA'IMAG ATAGGTAAGA TGAAA=FTG ATAATAMTG ATGGCAAATT TAAACAGGTA TACAACAAAA ATAAAAT7CT AAGCCCCTCA ACCAACTGAA TGGACTCCTI CTCTCAGCCA AAGGAATACC AAAGTAAACC TGAAAAACTA G=rGGCCA GGATTGGGGG TAGGTGGGGG AAGCCCAACA TGACTCATrA 7r(CTCTCCTC CCITGGAAT TCAGGCACAA CTGAATGTCA GCATI'GACAC TAAAACACAG ATCTAAGAC TGACAAGCCA GACTCITGT AGCAGAGAGC CAGGCCCTGG AAGAAATCAA G TA'IIAT CCCAAAAAAT A'I7C1TGA TATATI=CA AATGGCCCTG CAAAGCTGTC TCTGTGGGG AAAATTGACA TGCTGTACAG AATTTCC17C TCTTCCAAG TfI=ACTGA TCCAGGAGAG ATTAACTAA GAGGCTAGCA TGTTITIT 7FITI=lT TGAGGCGGAG T=~GCTCTG T-rGCCCAGGC TGGAGTGCAG TGGCGTGATC TCAGCTCACT GCAACC'FrCG CCTCCCGGGT TCAAGCGA17 CTCCTGCCTC AGCfrCCCGA GTAGCTGGGA 7TACAGATCC ATGCCACTAT GCCCAGCTAA I I I IGTATT 1TIGTAGAG ACAGGGTC ACCATGT7GG CCAGGCTAGT AT7GAACTCC TGACCTCGTG ATCCGCCCAC CTCGGCCTCC CAAAGTGCTG GCATTACAGG CGTGAGCCAC CGTGCCCAGC ACAAGACATr TACCGTCTAT TCTCTCrGAA. GCTACrATCT AGAGGCTTCA TCAACATAAT AAGACCCTrG GTCTCCACAA. CTCCT7ATCT TATCCTATTA GTTTCTACTG ATTCCAGGTC M~AGATAAT AACAACTCT7 TCAACCAATI' GCCAATCAGA AAGTVFIGA ATCCACCTAT GACTTAAAAG CCCCACTCCT TCAAGTrATC CCGCC1TCT GGACTGAACC AATGTACACC TATATGTGT TGATGGATAT CTGCCTGTAA C=CCATTCC CCTAAAATGT ATAACATCAA GCTGTAACCC AACCACCTITG GGCACATG IT TTCAGGAACT CATGAGACTG TGTTGCAGAC CTTGGTCACT CATA IMGGC TCACAGTAAA ==C'~AAA TA77GTATAG AG'LMGGCTr T1TCATTGA WO 00/09525 PCTIUS99/1 7712 EPI-109 69 CACAGGAAAA ATAAAGAAT7 GGAAGGTCT[ TCATCAGTCA CTGAGCCAGC TrCATATCTG ACTGAGGTCA TACAGnrCAG TGAMGTAG CTIGCTACT TAGAT7GCTA TCCATrATCT AGAAGCATCA GGATCACGTG GGACCTATTG GAAATGCAGA C'=CCTCCT AGAACCCAGG ACCI7GGAAT A ITCTTGGCA CATAGTAGGT GCTCAATACA TATTGAACTC CTAGGTGCAA 'FrCA FrAATrT CATGAATrAA TGAAT7AACA CGCTCTCAAA GTITAGTGCT TI=CACAGA CTAGTCTIC TGCCTCTTAA GCACTCAGCT CACCACGCTT CCAGTCTCAC TCCCCTATTA GTCTGATTAA AATCTG=TA CATGTGAGTC TGAGATCAAG TGYrATCTCT TCTGAGAAGT CTCCCTCAC TGGCCCAAAG GAATTTCTCC TCTA'I=rAG CACTGTCCCA GT7GACTTGT CATTATTCTA GTCTTI=CA TA7FAGTfGT T1TCATATA TATG77ArrA AGGAAACTAG TCAT'1TCCCC TAATAGAACA AAAT-rGCTGG CCTIGGGGT TGGCAATGGA GGGGAG3GCTC rrCITGAAAA GGGGGAAGAG TGTrCTCCTA ATATT=CT TACGAGAM ATGTTGCTCA TCTFAGCCT 17AGTCCCCC ATTGCCTGCC TACAGTITGGC AGAGACCATC TG FrCTCTCA CTGTCAGGAA CTGTCTCAAT T=TGAAG Fr CAGAGTCAAA AAAGAAGCAA G=hICCTAG CTTITGATC AACTITCAAA G=IrAC~rC CAMrGAAAA T1TACTAAGT CACCAGGAGA TGGMTATAC TGAGAAATAT CCACTCATAC TCTrCCTCTT CAAC'=CTrT CCATATACAC CCTAU7ACAG GGATATAGTC TITACTC7ATA GCTCAAAAGG ATGACCCTAT CAGAAACCTG CACAGTATGT AAAACATTCT CACCAGAGGT TCACTGTGT ATICCACCC TAGAATGGAA GCTCTACAAA AGCACAGAAT GTATCA=rr AAC=fAGAT TCTATITCA CACCCAGTGC TTGACACATG ATrGAAG T AATATI7AF7 TATCAAGTGA T-rGTIAAA ATCATGACTC ACTCAACAAA GflATAAGAA TAAGAATAGT GT7ACAGAAT TGGTATACAC AAGCTGACCA TAATCAACAC ACCTATrATC ATITITTGC GACAGGTTCT CGCTGTCTCA CCCTGGCTGG AGTGGAGTGG CATGACCACG GTTCACTGCA GGTIT7GAACT TCCAGGCTCA AGCAATCCTC CCACCTFCAGC CTCCCACATA GCTGAGCCCA CAGGTGTGTG CCACCATGTC CAGCTAA=T T~rAA17CT7 TGTAGAGACA GGGTCACCCT ATGTTGCCCA AGCTGGTCIr GAACTCCT7G GCTAGAGAGA TCCTCCCTCC AAGGTCCCCC AAAATGCTGG GATCTCAGGC AAGAGCCACC ATGCCTGGCC ATAATCAATA CACI1TAAG AATGCTAGAA TGTTATATCA GATGCATACT TCAGCACTAT CTCAAGCAAA CTGGGGTGTG GGTrATTCTA CATATAAAGT TCAGCAGTGT TGT-rCCACAG TCCCAAACTC CAACrGAGGT CAAATGTAGG GTGCAGCAAG GTCACTGGGG GTGTCATCAA GGGCCTCrCC TrGCACTCT7 GCCAACCCTG T TTGATT GTCTCTACCA CCATGAGTCA CCAGCAATCT CCCACAGTCA =~GTT7AAA AGTTCACAAG TAT7GTGTGA ATTGCAGGCA ACCC=TGAC TCCCTGATrG CCTGGTCTTC TTCCT7GGGC TCTACCATIT 7VFTICCCCA GCACTCITC TGCTGCTCTA AATITAA IT CATGCAAT-FC CATATGTGr TCTCTATCAT TCITCATCTC 'F1TCCTCTCC CTrCCATCCA ATFFGTTTG TCTGT'17GCT TGCTTG=TG CTAATACA 'FITCTCTI1 TCTGAGAAGG =~GAGTCCA AAACTCTCAG T-rACCTG'rrG 7rCTG T1CC CGTrAGTrAA TCTCCGAACC TTCATAAA'FF AAATCTGACA AAGTCCCCTG ACTAACAAAG GAAATGCACA AGTCACAGTA AAAGGGGCAC ACACAGAACA CAAATAGACC CAGGGTC=h TCTGTrCATC ACTCAG= TIT ATAGGAGA TCCAGGAGAA ATGAAGTGGA AAGGGAAGTG TGITrGAGTTA CTATACAACA CAAGAGTAAA CI=CTTATA AGTGGTAA Fr 7TIACA GGAATAATrG AAAATGGAAA T7ACCTCTC TACTCATAGT AAGTACTCAG TGCGTTCTTG ATGGGATGAG AATGTG=TG AGCI=AGTG TAAGcICAGAA TrCTGTrTAG TCTGCCAGTA rrGGAGAAAA ATAAAACACA AAGGGACTGA CATGTAGGAA GTGGCACCTG GGAGGGTCTrC AATrCTTrCCT ATrACAAAAA TGCCCCAGAG AAATAAAAAG =FGTGTACA TGTTGAGATG GGAGAGT7CT CTGGCCCCCC TCGCAGGATG TGTGACAGTG GGGTGGCTC-r CTGCTGCGCC ACCATGAGCT CAAACCCCTC ATAGGAGGGG GAGCACACAG GCAGGAAGGT GCAGGAGCTG GGCGAGCTCT TT1GGGCTCTG GCCCCGTGGT A~TGTCTAGA GGTGGGTGCC TGCAACTCCT GAAAGCCCAA GTGGGCATGT Gfl7ACAGTGC AVIXTICAG CITGCTGTC TGCAGCFTAA GCGTFAACCA GCTCAGMTC ITCrhGGTAC CCAGGTCCT7 GTCrGGCATC CAGGAAGAAT CAGGTTACAC ATGGACTTGA AGGATGAATG TGGGAGTIT ATGGAGTGGT GGAGGTGGCT CTCAGTGGGA TGGATGGGGA GCTGGAAGGG GGATGGAGTG GGAAGATGAT ATTCTCCTGG AGMTGGCTG TCCAGCAGCC GATCTCCTCT CCAGTCGTCC CCAGCCTCTC GACGTTCAGA TGCTCcrTTT CTCTC=CTrc CTGCCATGCT GTFCTGCCGT TCATCTGCCT GTOXCTCTCT GGAGCCrGGA ATI17GGGGTI' TATATGGTAC ACAATAAGGG GCATGGCAGG CCAAAAGGGA ACT7ITAGG TGCAAAAAAC AGGAATGCCT CT7CTCACTr AGGGCTATAG AT1TCAGGC flGAAGGTGG GGCCTIACC AGCGAACCTG TATrCCV1TG TCTCCTGTGC ATATCAATGT AATCAAATAC TGGGCTGATC CAGGATGT77 CITAGACCA AITATGGGTA AAATAATF17A CATTCAGG F7 'IATATIG CT1TGTCAT 'TCIT1AA GCAATCATGT AAAATATCTA TACGACAGTA ATAGATGATA GCGAACCTAA TTAAAATTAC CAGAAAC=A AGAATCTCTA ATGAT'I1CAA CTGTAACTAA GG'FrA'IMCT C1TATGTTG AACAATGTFG GGAGATAAGA CACAAGAGTr TCTGAAGTAT TrCAGAAACA CAAAGAGGGA GGTTATATAA ATAATATIT 'ICCTACTr TGGGAAAATG AAAGCTAGTC ACAAAG'ITAA ACGAGTGGT'r ATITAATAT 77AAAATACA GGCT7GGATG TATITCCTGT TAAAGAAAAT AAAATGCAGA ATA FTCAAAA CGTCTGACCA CCCrrCTAAG AAAATGCATC TCTGAGGTAT TTICCTTAG AAGTITATTGT AAAAATCCTG GAGAAGCTTG AACACAGCAA AGCAAACAGG ATGCAGAGT7 TAATCTGTGG AAAGC17AGG GAAGAAAAGC AAATCATTAA AAATAGGTCT TCCrCTGAAG ATI=AAAA CGCAAAGAGG GTGGAATAGC AATGATAATA AAAAAGCTGG CATAGAGAGT GGCACAA'17 GCTGTGCCAC TGAGCTGACT GGATGTGTrC TGAAMTCTA GGCA F7AGTG TACC1TCCA CACGCATTCT CCCTTAAAA AAAATGCCCA CACACTGAAT AC'TflTCA TGCAATIT7AA AATAAGCGCA CCATCTAGTr TACAGAAATT CACTAGAAGT TAT17ATCCT AAAATAGCAG AGATCTAGAA GAATITGAG CTCTAGGACA =FTAGACAC ACAGAAAGAA GAATCTGGAC AAGTCTGAC CAGACATGAC AGAATAGAAA 71TCI=rCC TATI7ATCTC TITGAATAAA AYITCAGGA T=TACAGTG GACAAGT17G TTATCTACAC A7rGTGAAGC ACATTGAITT CTCCTCTGTA GCCTTAGGAA GATCTGAGAG GTGACTGAGC TGAT7GAATG ATCCGTGACC GCTCTACTGG GACCAGTAGT AGAACTIAC TGGTGGAGAC CTGCTGGAGG n7IGAGAGCA GACITGAAA AT7ACTAGAG CTACACAGAT ACTGTGTGGC TAACTGGATr ATG IMAGAG GCI=CAGAA CTATGCTGCT GCTGCTGCAG TGTAGCCAGG ACGCACAGAG AACATCTAAG GCTC~rGAAT GGGGCGATAG GGACAGA'1 CAGCAGCCAT CTGACTrCAG TGCTCAT1T GATGC'TT7CC CTGCAGGGTG CAGTGTGCAG TGTGCAGTGT GCAGTGGTGG GAGGCTCACA CAGGAATACT TGC'FCTGTA GCCCTAAT1 CCGGTTCAAA CTCTGCATTC ACCTGACAG ATTCTFCCT TGGCCAAAAT 7rAGT'TAGGC T7CTGGGCTT TCTC'ITATGC CCACCTGCAG ACTITIGGT AAAATCCAGT TT-rAGTAAAG AGCTCTGCTA AGTCAGMXr GCAAGAATCC CCACCTCAAA AGTCACTATC TCccTccCTG GTAGTGTCTG GCTTGTC11TC AGCGAGAATT CTATrAGG'rr CTGTTAGATFT AGAATCCTCC FrACCCTITGA TGCTCCTCT TAGTATTT TCATCCACTG ACTCCTTGAC CCACCIGCT CCTCGGCTAT AAA77CCCAC ITGCCCATAC TCTGCAGYrA AGACTA=1I CTCCCCACTA CTGCAAAATC CCATTGCCAT GGTCCCTATA CTATCTCAAT GGTAATGAAT AAAGTCTGCC ITrACCATGCT T7AACAAGTA ACATTGAACC A'r=CT TrAACAATCT GCTGCACAAT GAGATrACTA AAACI=AT7 CCATITGCC ATGCTGGATG TCCTCAATGG AATGGCT=T1 GTGAGCACCA AATCA'ITGTG AGAAGGAAAA CCCATCTCT ACAGCCCCCT GTAACGTGAT GTATG77ACA TGTGATGTAT G'ITACATAGT 'TTTTTICAT G17GATCACT T1TGCCCAT TI7CCTATAT CTTATCAGT7 GGAAGACTGT GGAAG=TGT AGTACTAAGC CACAAGATGA CTAAGAAGAG 7FGAAAGGGC AAGTGGGGCT AAAAACAGAT TIrG1TrTGAC ITACCCCACC A F7CCCCCTA TCATGGGGCT GAATCTGCCT GGAGGAAGGA GCATCTIAT CTIGTACTG TGAACCACAC WO 00/09525 PCT/US99/1 7712 EPI-109 70 AGTCTAGCAG CAGCACAGCC AAGGCACT1rG GGG7TITCATG AGACTAAGTA CATGCAAT-rC TATTGTAAAG GCTrAAAATA TATACAACTG ACCCI17GAAC AACATGAATT TGAATrGCAT GGTCAGTrAT ACGCAGMTTr TcTrCCACCT CTGCCACCCC TGAGACAGTA AGATCAATCA ATCCTCTTCC TCCTACTCCT CAGTCTACrC AAAGATACF GAAGTCTACT TGAAGATGAC AAGCACAAAG ACA'ITrATGA TGATCCA=T CCACITAGTG AATAGTAAAT ATG=ICTC TCCTCCTAA 'Tr=AACA CTrCTC TCTAGCITAA 'IMATrGTrA AGAATACAAT CTATAATACA TATGACATAC AAAATATGTC YI7AGITGACT GTTrATGTFA TCTGTAAGGC TrCAGGTCAA GAGTATGCTA 'rrAGTGG~FrA AG=JCGAG GAGTCAAAAG GTGTATGTGG AC1TCAACT GCAGGGGGGT GGGCACCCCT GCCCCCATGT TGTrCAAGGG TCAAC1TAC TGCCAAAGGC AAGCCT=AC ATCCACTI= TCCATCCCAT CAGTAAATGG AAAAAGATAG CTACAGTATC CCTGCGTCAA ATCrfTI T TGCAGATCA CAAATTGGCC ACTCACMTG CTCTGTGAGG GGTAAAATGC CCCACT=CT TFIAGTAATAT TrAAGTrAGA TAATAMIAA GTITATAAAGT TGTrCTIGT AATCGTTAAT TGTAATIT ACATAGTrrC MIICAAACAG AAATAGCATF7 TTrGTrAGAT AACCTCCCGT ATAGATGATG AAACTCCI= TAAGGGCTAT CTGAATITA A FrCCTrGAA AAGGCAGAAA TrGGATAGcT AGTAGTCATA AATGTACTGT GGCTFCCCCC AACCATCTGG GCTATATAGA AGCTGCATCC 'ITGGACTGCA GTAGAGGAGT CT7ACAAAGC ACAGAGCAAC TrCTCTCCTG GG~rGCGCTA GTTATGATGG CAA'ITAAA TGTGTAC'= TACCCAAAGA AAATCCT1TAT TATCAACAAT CACAATGCCA TCATAACCAT GGTATAAAAA AITrCAAAATG TCCCAGCTGA AGTGGAGGCA AAGACTCAAG TTCATGGAGT CAGAGTI'CC TrGCTATTCC TCTT1TCAA ATGACCATI1T AGTAAGCACC TGAAGAAAAT ACTATGGACG GCA'TrGAAAA GTGAAGATAG GTI7AATCTT CTCGAAAATC TAATrCTCCA GATGAAACGC TGACACTTAT CCACCCCACA GACCCTATAG CAGATGTGTC ACTGGCCATC ACATIGACA CAGAGAAGTC ATAACTCAGT CAGCACAGAG ACA'1CCAT GAGTT7CTGA ACCATGGACA GAACGTCGTC TGTGGGACAT GAAAACTGGA A=~AGAGGA CAGGCACATC TGAGAAATGG GCAGIMAAA GGCAGAACAT AGCACATATG TGAC7GGGT17 T7AGAAGCAA ATTTACAAGA CGCACTCTTC T7CATCCTAA ATAATCTGCA ACCAAAGCT CCAAAAAAGA CAA=IIAGGA ATGCAGAGGT GAGGAGTAGG GAGGGGAATG GGATGAGAGA GAGTGGAGAT TAATGGTGGG CAGAGCGAGG 'TTAGAACTT AGTGG'TT7CT TCAGGTI'CTG AACTGAAAT-r TGTATACTGT AAAGGCACAA ACACCATIT TAACAAAAGT GAGCAGGACT TCCTATCTGG TI'CAGAAAAT AGGTGAATAA ATAGTACGAA 'FrATrAAAAA TAATAATTTC CACTIATACA TAGGAAACT7 GATAGGAACC ATGATAAATG CITAACTCTr AATCT1TCAAG GAACTCTGCT AGGGATATAA TATTATAAAT CTGTITGC AGATGGAGAA ATF1GAA=11 AACCCAAGTT ATCATAACCC TrAAATGA77 AAATGATACT GTTACATGAG AAAGCTGCGT ATCTGTIrTCC TGGATfGTA GCCATAA=T GTGTCTCAAG TCCC7I=GC TGCCAGCTAT CTTGGGTAGG TGTGTrCCCT TrGGGCTGTT TGATACCCCC ACATrTATCT TITFIIrfC TC7TIITG TFGAGAGAGT CITCCCTGT TGCCTAGGCT GGAGGGCAAT GGCGCGATCT CGGCTCACTG CAACCTCCGC CTCCTGGGfl CAAGTGCTrC TCACGA17CT C=GTCCCAG CCTCTCTAAT AGC1rCGGATr ACTGGCATGC ACCACCACGC CCACCTAAMT TrGTATITI AGTAGACAAG GGGTITCTCC ATGT7GGTCA GGGTGGTCTC AAACTCCTGA CCTCAGGTGA TCTGCCTGCC 'FrGGCCTCCC AAAGTGCTGG GATTACAGGT GTGAGCCACC ATGCCTGGCC CCAAATIT7AT CT'17AATGCC CCAAATTATC TAG'rrCCCAT GACTrGGGC'I CTG='~GAT CCTTCTGCA CTTGCTGGAC CCTCTCCCTG GGAAATGAGA T7GTGTCC7G AGCCCCTAGT TAGAGGCTAT GTCTCrGCTG TCCTGAATG GGCCTCCTGG ATGAGACCTC ATrFAAAAGTC TAAT7CTMT GGAGAAT17GA GAGATACCTA TTrGTCTCAA AATCATrGAA ACCAATTAAT GTATTATGAG CCTCTATCCA GTGATI17GTA CCTCAATFCC CCAATCCAGC TGTCAAGGCC AA'ITGTrCT ACCTrTACCTA GTAGGTAAGT CTGGAAT7GT AGCTGTGGCA T'I=CAGTAA TGGTACTCTA GG'TrAGCAGT CCCCAAC=T ITTrGGCACCA GGGACCAGTT TrGTGGAAGA CAATTCC ATGAAGGGCT GGGCAGGGGA GTGG'IMCAG GATGAAACTG 7rCCACCTCA GATCATCAGG CATFAGATrC TCACAAGGAG TGCGCAAGCT AGATCCCTCA CACATGCAGT TCACAATAGG GTGTGCACTC CCATGAGAAT CTAACACCGC TGCT7GATCTG ACAGGAGACA GAGCTCAGGC AGTAATACTC ATITGCCTrAC CGCTCACCTC CTGCCGTGCA GCTCAGTI'CC TAACAGGCCA CGGACCAGTA CTGGTCCACG GCGCAGGCAT CAGGGACCCC TGTI'GCTAGG TATAAGCATC TGGCTGCTGC ATGTC77CTG TGTAGCTACA TCTGTATGTG TATCTGATGA GATATAAATT ATTFGATTAT AAAT7AC'= CTTCATATTA GAGTTGTGAA TGAGTATCAC ATATAATTAT ACATAAACTA GGAATATGCT TIIAATAAT GTATATAAGT AAGT1T7C=T AACTATGACT 'PTCATCTTAG CGTAGTAAGA GGGTGCTAAG AAATATTrGT GATGAAAATA GGCAT'TGGTA GAGTTGAGAC CACTGGGTGA TGAAAGAGTG TAAAGATIT AAAGCCTICA GATGCTGGFF CAAGGTGAGA AATGTGA'I1G GGAGCAAATC AATTAACTTC 7FGAAGT=T ATAGGGCAGT TATGAATACT TAATGTTAAC ATATGTAAAG CTCT7CTGCC CTGTATACAG TAAATGCTAG 'FAGCTA'rrA TGATCACTAC TAAAATGGGG ATGACATAAA CCTCATAAGG TI=AAGTAT TATGCAAGAT ACTATACAAA GTCCAGTAAA TATCACATrC AAT-rGAATCC ATGATGTCCG ATI7ATIAG CTACTTCCAA GAGAGAAAAA AATGCTGTCA G=IIACTGT TCTTATAGAG AGCAAGGCAG ATCCCAAT7C CCAATGTGGT AACGTGAAAA ITT=GCATT TGAATCAACA AAACAC=rC TCC= =~r CCTACTAT AACAACTGGT AAGTCTATAC TCCCCCAAAT CTGGAATTCT CC1TCTrAT TCFITTCCT CCTACCAAGA CCGCAGGATC TITACTTGG CTATAAGGGG TAAACCTCAA GTAGTACAAG T1'CTC]TGTAT TACTTTATA CTCTGTCACA GATTCCCTT17 GT'17CCTCAT CTCCATGTGA A FrAGTrAA ATTCTCAGCA T7CTGATCCT TACTATACAA GGTAAATGAA TATAAAAACA AAACGAAACA AAAACCTCT7 CCrA'IMACA TAAGGCCCCA ACCTAATA T TAGTGATATA TATrAATGTG AACAAGGAAC TAACGAAGAC TGGGAAGAAA T7CACAGACT TGAGAGAAGA AATGGCAGGA MTCCTGGGA ACAA'I=CAT GTAACGTCAA AGGTGGTAAA AGGTCAAATA GAATGAAGAT GGAGAATACC GGAT1TCTr ACAAAATGAT TTCCCAGGAG ATCTCATCAA ATGCACGAGG ATACCTTCTC AG'ITrCACCT AGTGAGTAAA AGACTGGTAA CATAGCTCAC TFACAAT7G GATAAACAAA ACTAAACAAA CAACATCAAA AM~CAGAAA AAATAATAGC AAAACAGAAA TCAAACACTC AAAT1TIGG TCCTrCTGTF TATrCA FIT TGGATACTCA GTGAATGT7A ATTAACCAGG AAACTrAAAA GTTAT'1TCAA TTATGAACCT CTrCAATCCT TCATCAATrA TITGAGTAT TCTGGTCTTA AAAACATCTC TITCT7CrAC AAACTrCTGA AAGAGATGAA CACCTCCACC TACACCAAAA TAATGTGCTT TGCTGGCCAA AAGTACACGT CCA7IITAC 'FIAACAGTCT AAGGAAAGTC TGGTGCAAAT TACTATAATA ATCTGGGTTG TAAATGGnrT CTGAGGTGAG AATGAGATCA TA=T1ACAA AAAGTFITC ACTACTTAGT ACAAGCTrAC AAAACTCAGA CCACTCACCA GAAAAAAATC GGCAM~ATA TAGTTGTGF] ACTI=GG'Fr TCCTGCATCT IM7CACATCT GGCTCA'IMA CATCA=r~C TrCATC'ITCC AAAGTGGAGT TAGCTACTAC ATTAGGTAAG GTTACTTCAT CAATCACCAT ACTGTFATAA TC'TrGAAAGT GAATr'T7 GGACCCTCCC T7GAATGCAG TTATACCTAG TAAACCTGAT CCACAACCAA GATCCAAGAC TITITCCCA GCAAATI7rCA CT=GGCCT7 TGTGAAATAA GCCAGGAGGT CAAAGGTACA 17CCCAGA'T7 TTAAGCCTC CCTCATAAAC ACCTGTAATC AGATCAGAGT GAGAAGAAAA GCITITGAA ACTATGTIT CTCCAGGGAA GTT1CTCF1C AACAAGATGG TI=CACTAC TGATAACTA ACATGCTGGA AACCTGGTAA TGrrCTATG A=I~A=h CTAACATCIT C'T1AAATCT 'I1AGGCATAG CATGCT=TI GGCAGCI'CTC AAGGAGGGCT GTITCCATG TGGCTCCAAG TTC=TGAAC TGCTGGCTGC ACTGAGTGGA CTGTCTGTGT =~GAGAGGG AGCTGCATTT TCCATlGACT TATGITCCCA CAAGTGATCC TGAGGCAAGT CAAATI'G'ITC TGCAGAACAT MrCTGTCCC TCTC17CTCC 'FIrTGAC'rr TCTGAGACTG ACAGCTC'TI TGAGGAATCC WO 00/09525 PCT[US99/17712 EPI-109 71 AGGGTCAAAG CTCCATCTCT AATGGGTGTT AATTrCA=IT CCAGATGGTC 'FrCTATAGTG AAATTAAACT GAAAGGTCAT CCTCflATTA AATGCACACA AT=T1AAAT TCAGATrCTT CAACTrCTGG ATAGAA'TrTG ATGATACACA CAAATCTGCC TCAATTATTC AATTAGTIT GTTGGGCCCA A1TCTCTI AGCAGCTTAT ACATGGTAAC AAATAT1TAG AGATATICC AAATGACTT TTAGACGTCT YFGGTCCTCT TITCCAAGCAG CTCTGGAAAG AAAAAAAAAA AAAAAAGAAA GAAAATGATG A'ITAAAGCAA AATGGCACAT TFICACTAAAG TGTAATATTA AACAGCCACC CCCACCCCTC CCTGTCCCAC CATACAGCTG CTTCTI'A AAAAG'ITGTG GGGAAGAGAG AGAGATAAGA GA'I7GcGACA CTCATACACA CCTrAAGGGT TCCAAAGTGG GAGAAGAAAA TCAACTATAA AAACAAACAG AAGAACAACA GCAACCACCA CCACTACCAC CTGGACAAAC ATAAAGTCCA AGATATTCAG ACAGGACAGC CTAGCTACTT GCTGTCT=C AGCTGTCTTG ATTTGTGTCC AACCATATrC ACCCCCTAAG CTrCCAGAAT AACTTCACTr CTGTC'ITA CAGAAGAGGT GCAGTA1TI A=~GGTAA GTCAGCGTCC CrrAAAAAC ATGCATAGGT ATGGCCTGGT GTGTGTAAAT TCATCCAAGA CTICACTCCA AACATITAGT CGAGAACAGC AGCCCTAAGT GTATAGAAGT GGGGGTAATr TGGCAATAAT TAGTAAAGAC TAATTCGGTG GCAGAGCAAA CGCAAACTAG GGCACTGCAG TAGTFGGAG AGACCTGTAG AAATAAGAAG CAAC'I=ATT GAGAATC FTC TATCTACTGC GCTAGACACT ATACCATCTG CCTCAATIT CACAGTTCTG GCAAGTGGGA TCTTGTTCC C'=ATACAA GATTrACAAT T'FGGGGGAGA GGCGGGTCAC CCAGTCCCGC GGCTAGGAAC GCGCCTCFI CCTCTCCCAT CACGCTGCAA GGCTTFGGAGT CAcflCCGGC TGCAGGTCCC GGAACAAATC CGACCCCAGA AGTGGGGACT TCTGGCCCTC ACCTCCCCAT TrGAATGTAA TGITTrACAGT GATCCAGACC TGGGGATGCT TG=TCCCGA CGTGTCCTGG GATCGCGCTr CTGAAAAAGC TCACCTCACA ACGCCTCCTC CGGACC]TAAA TCGCGCACCA GTGAGTCGAG TCCTCCAGGG GCTAGAGAAG CCCGACITC TTCCGGCCT TGAGGGACCC GGGCTCACCA AGAAACCAGC CGCCCTCCTC TCTATGGT1T7 TGGAGCCGGC GGAGAGCGCG CAAGGGT7GG CGGGACTGCG AGTfTCCGGT CTGGGC1TG GCGGGTCTGG T'FTGAAGCTC TCCTGFIGA CGAAAGTATG TCTCAGGAAG GTGCGGTCCC AGCTAGCGCG GTTCCCCTGG AAGAAT7AAG TAGCTGGCCA GAGGAGCTAT GCCGCCGGGA ACTGCCGTCC GTCCTGCCCC GACTCCTCAT ATC=rCC'rT GGTTGTCACT TCTACCTAGA GAAGGGTGTG GGCGGGTCGC GAACC'=CT CT~rCTGTCCC TTCAGACCCA CCGCCAGGCT GGG FIATATI' ACCGCGGCCT GAACCCCCTC T=rCI=GT CAGTGAGTGG GATGAAAAGT GAGGGACTGG AGGGGAAGCG ACAACCGTGG TAGAITIAAG TAAGGCT=G GCCCTGGAAA GCCTCGCGGA CGTGTTCTGA CCCAAGGTT TAGCAGTGGA TGTGGCGTFFI TC'FrCCA'ITC C'FrC1CAG 'T]TICTGTA CTCGTTGC7T GCAATTAAc3T GTAAATACTI' TTGCTAGTGG ATAATGGGGG AGGCAAGGAC TGAGACCTGC GGTATGACGA TAGCTCTGGC TCTTAATAGT TTGAGGTAAA GCGAGATACT CTGAGCflT GTCTCCCGTA AAAAGGGTGG TGAATATGAA TAAGGGCI= CT7AGCGTrA TAAGAATTAA AGGGCATAGT TCTGTGGTGT GAAATCT'1TA AAAGATGF1rC AGTAAATAAA AATGA=IIC CTCCTTCCCC TCTCAGACCT CT11T-rflC T=rTCTr 'TTTGAC AAG'TCTCAC TCCTCTCACC CAGGCTGGAG TC3TCTGAA AGAGTrcTh7C CG=TF7 GT TGG=TFCAA CTGTTGGATT TGAGGCGCT? AGCGCCTrCT TCGTCCGGGT GCAGCACA'T CTrGATrGGT CTCATGC=T TGTGGTTGTA AATGTGCCTG GAATCCTAGC C1TCATGGT AAACCATATG TATATGTATC ~fT=CACAA CATI1GAGCC CAGC=~ATA CAATTACACT CAAAAGAAAA AAAGTAACCT TCACITGAGA GAATCTCAAT ACTGCACAAA TATTGTGCAG CTAAAGCCCT ATGTAATCAC ATAGAAGTCA TrCACCTAGG CATTAGCAAA ATCTCAGAAG GTGCCAAAGC CCCCITT= AGTIrGTG TAGGTACAGA ACTGCCGTCT TCAAGGAG~r TCAACTTGAA AACAAATAGC CACCCTCAAA ACAT7CAAAA ACACTrAAAC TGCGTGCATA ATGTGTGTGA GACATGGTGT TAGGCITGG GAGAACAGAG ACACGGAACG TGAT'rCCTCT T=TCCCCAC AAGCT-rATAG AGAGACTrCA TFTAAGTTGAA AGTCAACAT7 CCCACCTAGC TIGCACTTC AAACGACATA TCAAAAAAG CCCAAACTrC CTCTAGTI= =TCATCT73A GTAAATGG T TCACAAACTG AAACCTrGAA TCCrCTCTGT CTCACACACC CGATCAGTAA GflCTKI1TGT TTCTGATTCC AAACTATGTC T7GAATCAAT CCG1ATCT CCATCCTCAT TGCTACCACT CTGATTCCAA ACCCTATCA CCrCTCACTT GGAGTATTAA TAG1T1rCCT GMTCTrACTC ATAA~rCATT ATTCCAAAAA AG~rAAGAGG GGAAAAACAT AGATCTCGTC AMICCC1T TrAAACCACT TrACCT1CAA GGTI'CCAGGT GATCTAAGCC T7GCCCT7CT CTCATACCTA GTrAATTAAC TACACTCTGT TCATGAATAC ATTAGGCTCA CCTACCTCAA GATC'rI IIrG CTCAGCCTGA Tr7GTrCTCT CAGCCTITG CATAT=CAT GFITATGTCT TGGCCCAAAT GTCACT'rCCT TAGAGGGGCT TVFCAGAGC CTTCAATCTT AGGCAGTTCC CCCAAACGCA GTCTTACACT TGTATCACAT TGGCCTGTTC AGTITCTAA AAAGCACATT ACCATFAAAA GAAATGCTCT TG=FGCIT GTATATITC CA=~CTACA CA'FrATG'FrG CAAAGTTCAT AAAGGCAGGA TGTFFGATII =TCACAGCG FFACCCTCAG CACCTAGAAC AGTGCCTGAC ACATAGTAAG CAT7CATTAA AGGGCTAAAA ATMTTTCATG T1TAAAAAT ACTTGGGAGT CTAA'FrAGAC AATACTIf TTCAGC'ITAA TGGTAGTAT7 TF7AGM~CAC TA=FTAACA AATGAAAAAT TGCAATAAA TCTACAATGC CArrACCCCC CAAAATC1T TTCATGTIT GCA=I~ACG TATrA'ITC CAGGCCTTAC CTGCATGTCT GCATAATCAT AACTGACTAA TITGGAACA GCTGGTAAF[ A'FrGAGCT TACTGAAATr =IrCATGAG GCCAA1TCTA CCCTACTGAA CTCAAATI17G AGTTAATGAT GACCTCATI1 TGATIX3CTGC TGTAAAAAAT AAGATTTFCGG AAGAGGAATG AATT1CTrGTA TTACTGTGGT AGGACTATGG GTTTr c3G'1TGT 'FrGFIGAG ACGGAGTCTC ACCCTGTCAC CCAG~1c7GGA GTGCAGTGGT GCGATCTCAG CTCACAGCAG CCAGGTrCAA GTGA7rCTCC 'FrCCTCAGCC TCCCGAGTAG CTGAGA'FrAC AGGCACGTGC CACCATGCCC GGCTAATTF TrGTATCTF AGTAGAGATG G'TTCACCAT GTTGGCCAGG CTGGTCTCGA ACTCCTGACC TCGTGATCCG CCTGCCTCAG CCTCCCAAAG TGCTGGGACT ACAGGCGTGA GCCACCGTGC CCGGCCGGGT TATTCA=I~ TC'IATrAAC ATF71TGAT GATTCT7ATG GTG'TGTTAC AGTAAAACAT 7rCTAACAAT TATTCTAACA ATTATnCTTG ATGGTGTATA TGAAGAA'1 ATrGTCGTGT A'I=GTAAGC TGCTATGTGC AGAAGAAI7r CAGTCAAATA AAGYTGGTAA GATAGGTATG TAAGTAATAT GAAAAAAGAT AGAAGGTGAT GAGTGACTrA GGTATAAATl AAGTACAATA GAAATGTTGA GGAAAGAAAA AM~CTTGTA ATAGAAATCG GAAGTACAAA CTGGGCATGG TGGTGTGCAT CTCTAATCCC AGCTCCTTrGA GAGGU1TGGTA TGGGAGGATC AC'TIrAGCCC AGGAGCT7GA GGCTGCAGTG AGGTGTGATC ATGTCACCGC ACTCCATCCT GGGTGACAGC AAGACCGTCT CTCT1TF FTTTGA GACGGAGTCT CGCCTATGCT GGAGTGCAAT GGCGCGATCT TGGCTCACTG CAACCrCTGC CTCCCAGTI1 CAAGTGATrC TCCTGCCTCA GCCTCCTGAG CAGCTGGGAT TACAGGTGTG CGCCACCATG CCCAGCTAAT TA1TIGTAT TITAAGTAGA GACGGGTTCT CACCATACTG GCCAGGCTGG TCI17CAACTC CTGACCTCrr G7TCGCCCAT CTAGGTCTCC CAAAGTGCTG GGATFACAGG TGTGAGCCAC CCCAC'ITGGC CCCGAGCGAG ACCCTCTCTC TAAAAAAAAA TAAATAAATA AATCATAAAC CTGTGGATTA TTGTAGCATI7 GYITCTCATC TGTCAAAAAT A=flCATGAC TATGCATAGT T7GAAAAGGC AAG'ITGTCC CTGGGCAATT TTCAAAATAT T7CTIAATG TGTITCACA ATAC7GThrA CCTAATAAAT CTrAAG=Ir TAAAAGCAAA A'TFAAGCCAG TAAM1GAGT CCAATrCCAA TCcrTATGA GTCATTGCTT AAA'I=CAAA AGGGTT=AT TFTTTA GGn7IT7CT GAGTAATGAA TACCCTAT-rA CTATGATACT AGTATCTTCC TrAATrATCC TACTCATTGT CTCAACA'ITC TGACAGTITGG ATTGAGCATA 'FrCGTAAGTA AAATrGTI= AACTGTATGA TGTA='~GA TGTI'AAGGTC CGAGTCCCCA CATACCTCGG TAGATGTGTT C'ITACAGTTI TGTA'FrCCCT TGAAATGTAA CTGTTCTCTA TGT]TACAGCC =IATAACCT TCAGTTACTr GAAATGAACA AA'FrCATTCA AATrCCAGCA WO 00/09525 PCT/US99/17712 1tii-109 72 c'rAAAAGTT 'PTAAATTACA TI=GGATAA ATACCAAAGT GTITGTTGA TGATGTATGT ATAAACAAAT TGTAAATA TT AAACGTFrAGT TGTTACGA Fr AGACCTATAT AAAACATGAT ATGCAGTCTA CTGAATAGCT ATCAGCCTCT AACATGMTA GTGTCA'TA GAAAATGCTT TCTAAATFGC CAAAAGCTGA TTGTCTAGGT GATAACAAAT T7ACCATTG GAGGAAGTFG Ac=rCTCAT TICATGTCT TCATCAGTCT TACTIGATGA GATTCATTCT TCTAGTCAGA AGAGAG TF7A GACTGCTCAG TI7rACTCATA =F~GAGTFrA GCIrAT T7AGAGTTCA CTGGTTGTG GAATAYI'CAT TrATAA'ITG AATCZTACG'rr GTGTAATGGG ACCTAA=T1 T-i=Ccrr G7rnTFrG GAGTCTCGTT TITGTCACCCA GGFGGAGTG CAGTGGCGTG AT=TIGCTC ACTGCAACCT CCAC M CCA GGTFCAGGTG ATTCTCCTGC CTCAGTCTCC CAAGTAGCTG GGAYI'ACAGG CATGCT'TCAC CACGCCTGGC TAA'TI=GT ATFITAGTA GAGATGGGGT 'FrCACCATGT TGGCCAGGCT GGTCTCAAAA CTCCTGAGCT CAAGTGATCC TCCTGCCT7G GCCTCCATAA GTGCTGGGAT TACAGGCGTG AGCCGCTGAG CCTGGCCCCA GAITTG'I TG=1TGTr TCAAGACAAG ATCTrCACTCT A'TGCCCAGG CTGGAGAGCA GTAGTGCGAT CATAGOrCAC TGCAGCCTGA ACTCCTGGGT TCAAGCTA11 CTCCTGCCTC CATCITCTAA AGTGCTGTGA TTACAGGTCT GAGCCATGAT GCTTGGCCTG TGTrrGTr TG 1TGTI GGGGGACAGG GTC=Gcrr GTCACCAAAA CTGGAGTGTA GTGGTGCGAA CATAGCTAGC TCACTGCAGC CTCCATCTCC CACGCTCAAG CAATCCTCTC ACCTCAGCCT TCCAAGTAGC TGAGACCGCA GGTGCGTGCT ACCATGCGTG GCTAA'TITC TA'ITATATA MTATT=T GGTAGACATG AGGTC=GTC ATG FITCCCA GGTGGTC1T AACTCCTGGG CTCAGACAGT CCTCCCGCCT CAGCCACCCA AAGTGrGGG ATTACAGGCG TGAGCCACCA TGCGTGGCAT AA'TIT!Tr AAGTAAATTA TITITIATC 17GAGTATAG AAGTGATCA TGT[CATrGT GGAAAATATG AAACATATAG AAAAACAGAA AAGATTACAA AACATCTAAT CTGAAATGGT TAAGAITIG ATGAGAACAG TCTCATCTrCA TTCCGTATA flCCTGCCAG C~rATCCATC ATTCT7CGTA CATGn1TATC TACATTAAAA TTrGGTG'rrAT A=IIGGAAA C'TTGTnr AACTACATTG TGAACAYI= TCATG=IIA AAATGTCA FF TrAATGATGG CAGATCCTAT TCAATAGATG TACACACACC TAM7rAACTG GTCCACAA'Fr GTTGGATATG TAGGTCGTFI CCTTCTCTC FfT1Trf[ ITTrGGCTA CTA=TAATA G'TICTCTGT ATAGAATGTG GTATI=GAA AGTGTATCAA GCT=AGATT GGTAGTATTC TTGCATITAA TAAAGGGCAG TGGCC'=GT TGACTGACAT GACAATA=T T7ATAAAATT TGFI'A'ITGC 'ITACAGAAA TITGAAAAT TATrGTAGAA ATGTIT1AC CTCATATGAA CCACCTGACA TTGGAACAGA C=CTC ACAAGTGTTA CCAAAGGTAT AATACTATTA CCTGAAAATA CATGTrFATAA GGAATCTAGC CTCAGTCTA GATGA'F17AT TATTAA'T7AT GGCTCTCTI T7CTAATATA TCAAATATAT TCAAAATAAA AATAAcIGAGT AAGTAGATCT CATGTGAGAC TATAATGGTG TTAGTGTGAT CATFIAGGCAG T7AAAAACTG 17ACAGGCTG GGCACGGTGG CTCATGCCTG TAATCCCAGC TCTCTGAGAG GCTGAGGTGG GCAGATCATC TGAGGTCAGG AGITCGAGAC CACCCATGGT CAACATGATG AAACCTCGTC TCTACTAAAA GTACAAAAAA TTAGCTGGAC ATGGTGGCAG GTGCCTGTAA TCCCAGCTAC TTGGGAGACT GAGACAGGAG AATTGCTTGA GCGTGGGAGG CGGAGGFI'GC A FrGAGTCAA GATCGTGCCA 'FrGCACTCCA GCCTGGGCAA TAAGAGCGAT GCTCCGTCTC AAAAAAAAAA AAAAAAAAAA AAGAACT7AT A=F~CAGAT TGTGTGGTrC C1TACTAAC TGAATTrAAA 'FrAnI7GTAG TCAAITIAA ATGCTCT7GT A=~AAAGC CACTGTACTC CAGCCTGGGT GACAGAGTGA AACC=rAAT TCAAAAAAAA AAAAAAAAAA AAGAAAAGCT GGAATATTGG CAAAATCAAG TAACTAAGAG AAAACATrAA ATTCACAGAA TACATATT1A CAT1TAGAT ATATATGGTA TATGITTCT CTGAAAAGCA CAAGCATACC rTr=GTTr TAAATGGAGG GAACTAAAGA TA=1TGGTG CCAAAATGAA ACA FrATG TAA17AATCT C'FATrGAAA TGGGTIfCTA A='~AGCTr TGAATCGTAA TC1TCAAAT TTCrrGTACT CATAGTCACT TGATGATrCT CTATCTGAAA TAITFTrAG AAMT11CT TGACCACCAG AAAAAGATTC AACTGTTACA TAGATGAAAA TGGATGI17GA GTGTTAACAG GCCTATGGGA AACAGTATr TCITAGCTA CA77GTATI1G 17GACTGTGT TGCTATTCTr ATAATGTTA GGTCAMAA ArrGTrAGAA AGATCCAAGT ATTAAGATCT AGGGTGGCTA AC'IrCACA GACAAAAAGC 'rTG'IMGTAA GGTCA TITAC TATACC=~A ATrCAGGAAG GTrAGCFITGA ATTGGGTCAA AAGGAAACTG G~rAGAAAAT AAGTGAGTAG TGAATAGGCG A'FrCAGTGCA AATI'CCTI7CC AGAAAATACC =TGTAAATG ACTGTATGAA TGTGGATrCT TCAAGACAGT CAAAT17ATT GTGCGAAAGT AATACTIA I-rTTGCAT CTCTAAAACA TGAACTIGA GTGATTIT AAAAAAAflG ATGCTATTAA ATAGATrCAA ACCATAGAAA TGGAAAATAA A'IMCTGT1Tr GGGGCT1TG GGGGGA'ITAT GIGTAAAAA TACCITICT CTGTA=IrG TGCTrAATTA GGTACAATTG TTAAGCTAGA TGATAGCCTG TGGATG'ITAC TAGTGCAAAA TCAAATIATC GTATrGTG'Fr TTCTCTGTAA AG1TFGTCT TGTCTITCT AGTGATTCT C'ITATTCCTG 1ATTA=F GATFFG=Ir TACAGACTGT GAAATTA'rrC GATGACATGA TGTATGAATT AACCAGTCAA GCCAGAGGAC TGTCAAGCCA AAAMIIGGAA ATCCAGACCA CTCTAAGGAA TATITACAA GTAAGTCAAA TGTATTAGAA AGCAGGAGAG AGAGGGAGCT TAAAGAATGT CAAAATflT ATACTGATAC TGATITAGCTA TGTAT~A TGTAATGGCC TAATG7TGGA ATTAAATITA TAGAATFTAAA GACGTGAATA TAGAAACATG AATTCTGAAT AATAAACTCT TATAAGAAGA GAAGTCATCA AGCTAGCTGA CCCTACCTGT ATITCAAGG ATATGTGTGG AACACCTGCC ATGTG1TIG AAGTTT7GTGT TAGTATTCTA AATGGCTAGA CAGT7GTrCC AGTAM~GTA G'FrGATAG ACTAAAGUrC TGTGAAAAGA GGAAGAGACT GTG=ITGTT CATTGCTGTA 'ITGTAGCAC CCAGCATGCT GACTAATACC 'fTTCAGTGC ACAAAAAATA TATTCTAAGT GAAATITCCT TCCTrAT7CA CAGACAATGG TGCAGCTC'r AGGAGCTCTC ACAGGATGTG TTCAGCATAT CTGTGCCACA CAGGAATCCA TCATI=GGA AAATATrCAG AGTCTCCCCT CCTCAGTCCT TCATATAATr AAAAGCACAT TrGTGCA'rrG TAAGGTGAGT AAAGGTCTAA TrATACITG AATGGTATAT AATCAATGTG CATAGGGGCT GAGTAAAATA ATGT'1rGTAT AAGATTIAC ATITAGTCT ATATTATTGA AATAAAC'TI TCCATAGAAT AAAGAACATG TAAGTAAATA AT7GTrTGCAA AAAAAGTGGT 'FrTAAGGAAG TCATTAAAAG TGGCTI=hG GGG~TIT=A G=ITATCTT A'IMCCCCTC TATAAAGAAA GAAGTTAA GAA'ITIGTGT TGAGACAGAC ACAGGGATCC TGAAATAGT7 ATGTCATGTr GCATTGACCA ATATTCAATT ACCA117ATGA flAGATGTCA GAAC=CCTr 'ITATAAAGGA AAG'TAATCC 'TrA1TAGTC CATCTCTACA TGCCAGAGGT AGC=TGAGG CACAAAAGCT TGCCTAGAAT TrATGGGTCA CAGACAGTr7 TAATATTGCT AT-PTGTTGGG CGAATGAAAA TCACTAGTTA ATITAATACCT CTCTTGCTG ATAGGATGCT AAAAATGTCA CGCACCTGGC CTAATGTrAC C~TIT=AG TTCTGTAMf GCAAGATCAT GGAAGTCAGA AATAATATI' TATACATGCT TGCATCTCTF GAAGCACACT ATA'ITTAATG GATGITrCACT AAACAATGAA TGAATATGTG AT7CAGTAAA 'IMATGATCT CTAATAGTAT GAATJ7AAAGT AAATTrGGCT C~rGAG='~ GATITGTFF 1rrCCTCATT7 TrrATrATC CGTAATCAGA ATAGTGAATC TGTGTATrCT GGGTG'1TAC ACCTAGTITC AGACC'ICTC CAGGCTIT TCAAGGAGGC CTATrCTCT7 CAAAAGCAGT TAATGGAACT GCTGGACATG G7FI7GCATGG ACCCTITAGT AGATGACAAT GATGATA=T TGAATATGGT AATAGGTGAG TGAAGAAAAC 'FIrCTG=~A GTATATGGTG ACTATAAATC ATGTATCAAT TAAAATrGTC TCTAATGATT CATGT1WT~ TCT~rACTAAT TATGCAT[AA AAT1TGATfrA AAT=TACCA AATAAA FTI TAAT=TGAA ATITGGAAT7 TGTAAAATI1 AITIGGGTA CCTrAACCTA GA'ITGCGTA T'F7AGTrACT GTAAMhCTC CACAATGATT AACTTATATA AC1TATAAT CTCTGAGGTT GTCCATATTC AGAGACAATA A=r~CACAT 7I1rTAACC ATAACTGATA TrGAGATGCA G'IMATA=I C=ICCAGAA TACATATAAA TACGTGCATA TGTGTATGTA AATATGTCTA TTCTCATATA CATATI7ATAA TGAAATAACT CAI=rACAT WO 00/09525 PCT/US99/1 7712 EPI-109 73 GTGATGCACT TrATACTAGT T7ATTT=AT 'ITA=iAT TTTGAGA CAGAGTCTCA CTGTGTAGCC CAGGCTGGAG TGCAGTGGCA CAATCTCGGC TCACTrGCAAC CTCGCCTCCC GGACTrCAAGC GA~FFCTCCTG CCTCAGCCTC ATGAGTAGCT GGGATrATAG GCGTCCGCCA CCACACCTGG CTAATFITG TATIT1AGT AGAGACAGGG MTCACCGTG T-rGGCCAGGC TGGTCTGAA CTCCTGACC T CAGGTAATCC ACCTGCCTCA GCCTrCCCAAA GTGCTGGGAT TACAGGCATG AGCCACCGTG CCCAGCCAAT ACTAGM~AT 'TFFAAAGAA TTGCTGGTCG TAACACACTT CA'rrGAITT ATCACTCA IT AATOGATI'AT GAACAAGAGT 7FGAAAAACA ATATAAAGGC AAAGn7TGCA 'I1CAAAACTT TGGTATAAAG AGAGTAAGTT GGTITGTGC AGTGTATCAG GCACCTGT7G CTrCTGCAACA CACCACCTCA AAATCTrAITT ATTCACTATr TAITATICA TGATITCTGTG AGTCTGCAGT TTAGGGTGGG ATGTCC TGAG ACAAC1TCT CTGATCCACC TGGGGCACTA GCTCACCCAT GTGACT7CAG TGAC'FrCA'rr CACATCTGGC TGT7GGCAGA GGCAGAAGTA C=GAGAAAG CCATGTGCAT CATCCAGCAG GTTCACCCTA TCTCAGATAC CTGATGCCAG TGG1T~CAGG G'T1CTAAGA GTAGCAAAAG TGTGAGCAGG TCGC TGTGTG CTAGCAC'TTr TCAAG'T7CT GCTrGCC'IA ATrArrAT TGTCCCCCGG GCCACAGCAG GTCATAGCGT T~rAGCCCAGA GTCAUrGTAG AAAAGTGTGG ATrCACAAAG GGCAGTCATr GTGGCCATITr ATAAATAA TCTACCACAG ACTGAGTAAA AGCCT7GCAT GAATACCATG GATAT-fAA'Tr TGAATTCTFC CiTXTAGAT nI7CMrCCT TAGCAAT~rG TI=GTCA'rT 'ITGGA ITAGA ATTATATCTG TAGAATA'IT CAGrATAAT AGGGTACAAC TITATTCCA CTGAACATCT TJ7AGTI=AT TrAGGTCATC TGGTAGGTAT AAACTTCAGA AGTTAATATr CAATA IMAT AAAAACCATT AACAAGTGTG ACACIAAAT AGn7TAAATA A'TTTGA CACAAC TGT7 TCCAAG'FrGT GTTACGTAT7T FAA'FrCAAT CAAATGTTGA AA FrGTrCAG TAGATAGMT TAA17ATAGG AGAAACTCAC CCCCATGACA 'TFGGATGTC T7AAAAGT~rC TGTAT='~ C1TGCAGTT ATFCATTCTr TAT7GGATAT CTGCTCTGT7 ATTTCCAGTA TGGACCATGC AT-I'CATGCC AATACTTGGA AGTrATAAT TAAGTAAGTT TG'ITGTrAT 'TTMAC'IT7 AGAAAATG =IrCCATAT TCCCCAATCT TAATrA'ITCA TGATrT=A GATTGCAMT AAAACA'IFI GTGTGAAT7r AATGT-TCACT GACACTGCTG TCTGATAATC CAGATATTCT ACATGTAGCT CTCAAGCCAA ATFGGACTTC 'IMACCCTrGT GGCC TCTAAA ATTAAAAAAA ATGTTC'rrCC TAG'ITAGCTA GTACTrCAGA AATAATGGGC CATGGGCCAG ACrAGAACT AACCA7= CTrCTGCTAC TGTTG2TFAA CCAGCTATCA AGTATCCTAT TTCTAGGATr AGATAAAT7G ATAACTATAA 'ITAAAACTGA ATATAATC TT FCA17AGGT ACTITAAGT TGT7CACACT TAA'FrCCAr TGTACAGTAA =ITAA=~r CTGAAACTGA AGCA=FTAA AGGGTCACCA GGGATAGTGC CTGTAGCA1T CATCAGATTC 'FrAGGGGTGA GAGGAGATGT GGTTGAGATG TAAAAATGGT TAAGAATATC TACITIATAC ACATACATAA AACATITAAAG GTCAGTGTAT TTCAGGTCT TAGGTAC'= T=TGTACTA CCAGGACATT AAG77GCCAT TCAGTGGT~rA AGAGTGTrGC CTGGGAGCTG TATCACATGT GCTTAAATCC ATT17GAAA TCAT1TrACTC CTTCTGAGCC CTTGGGCTAT TTGGTTAAT7 TCTrCTGAACG flAGT7GCT CATCTGAAAA TGGAAATAAT AATAGCAACT TCT~rGACAGG GTTATAGTGA GAA FrGAGTrr CATCACTGTG AAATGCTTAG AAATGTGCAT GACACATAGT TAATACTCAA GGAA'ITAGCC ACATCACTAT CATCATCACT GATrATC'FC CACTCTTACC CTCT=CCAGT TCA7ITCTG CCCAGCAGAA TGATC'TITA AAAAGTAAAT CAGATCATGT TACTCTAT17G CT-rGAAGTCr ATCCCATITG AT7AAGAATA ACAACCTrAAT CC TCTGTGGA TGCTGCCTrCC FrCACCAGCC TGTCTrCATGC TGCTCTrCCCT ACTrrAGT-r CCTCAAACAT ACCAAACTCT CCTGTCCCAG AGTCITTCG TGG T1TCC ATCTGCCTAG GATGC TTCTC TCTCCTA IT TGTGTAC=T GCTrAAC TCCT GCIACTGTC TTTCAGT7Tr CAGCTrAAGA GTFATATCT CATGATAACA TTCnITGATA TCCTTACCCT AAGAUTAAGT TAGATrGATA TCCTACCCT AAGAATAAGT TAGA'T7AGGT CTrCTCTA'ITG TAGCACCTrA GACTCTGTCA ITrGACAAAT CACAGCCCTA ATrAATTA17 CT]7AAAA'TrA 'ITAACA~rC TCTCTCATGC TAGACCACAA G'IMCATGCA GGTAAGGCGG AGAUrGTGTC CATTG'IG ACCCCMTGT CTCCAGGGCC TGGTAGAATG CCTCATACAT AGTAAGAATr CAATTAATAT 'IMACACAGA C1AAAAAATrA GCAACTTAT7 TAAACAAATA TAACTGCT7C AGAGGTAAAC TGGGCACATC 'FrAGIT7ATAT TATGTGATAT ATGATGCMT TrGATrGTr YITAAATGT TCTACAAGGT AGATATrGT7 AGAGGTCCTA AG'TAC~rGA TGTGTTACTT GTGGTGAIT7G TATrCTITC 'ITITrAFCA TTTAGGCAGA GCC'TrAAGCA CCAGTCCATA ATAAAAAGCC AGTTGAAACA CAAAGATATA A'ITACTAGCT TGTGTGAAGA CATT71TTC TCC=CCA'rr C17GTTTACA GTTAGCTGAG CAGATGACAC AGTCAGATGC ACAGGTAAAA 'IMGGGCTAA TAGCA'ITFA AACAGCAACT CT-TATTCT TI'GGCAG'F[A GTAAATCTCA I=GAATGTC TGGGTCAGTC TA'ITAAGAG GAT-=AA'Fr TA1TCA717~ GGGTGT1TT YITGATCTG TGGGATTATT TATATCCCAT AATTACTIT CACCCAGAGC A'FIGTAT7AG ATTCCTAACT GCTGTCATTG CCTCTGGGGT CTGCCTGGCT CCCTCMTGC TTGGTAACTG GTTGGTCACA GCA FrCTI1CT CAGAATCC= TCATITCTMT CTGCATGAGA ACAAAAA'T7C TITG77CAT AITTTGTATAA GATCTGATAT AGCTGCAATC AATCTTGCAT TITCTTCA CCAACGCA'IT GCGAC='TA GGGATACAAG TATGMTGTG CATGTATATG TATGTATCAG TCFXTAAAT TrGATATAGT CATACA ITG 'TI=ATI= GAAAAGTTAG AGTGTTGAAT TGGTATCCCA 'TrTATGAAAC A'TATATTCTF AAAAA'I=GT AGTACGATTA T7GGGAATTA TAACTrCA'T7 TCCTGTAACA CTGTTATACA TAGTACC'IM TGCTTCAGA CTAGCCC~rCA ATITAMTA ACTATAGTAG TCCTAAATrA TAAGATFAAT AGTACTCAGG ACCTAACAGT TATATGTCAT 1rGTITT=~ TTITGAG ATGGCGTCTC ACTCTGTCAC CCAAGcTGGA GTGCAGTGGT ATGAC=~GG CTCACTGCAG CCTCTrGCCTC ACGGG'I1CAA GGGATCGflC TGCCTAGCC TCCTGAGTAG CrGGGA'ITAT AGGCGCCTGC CACCACGCCT GGCTAATI= 'TAGTAGAG ACGGGG'ITrC GCCATGTTGG CCAGGCTGGT CTrCGAACTCC TGACCTCAGG TGGTCCACCC GC=TGGCCT CCCAAAGTGC TGGGATrACA GGTGTGAGCC ACCGCGCCCA GCCTATATGT AATAA I I I IA ATGGGACCAT GAATTGAATA nITCT7CCTr GAATAGCAAT GACATAGCCC MTCTATTGT ACATCTGCAA GCTGATACAG GGAATrCCTT TGTACCTrGCG CT=~CCCTG CCAGTCAGCT ATGGGGGTGA AAGTGTAGGG GTrCATCCAA GTCCTAAAAC TGGTAGCAAC TCC TAGGGCA GGGCTGATCT GGAAGGACAG ACCCTAGGGG AGGGTGGAAC 'ITAAAAAGA AGTTCTGAAG GTAGTAAGAA GGAAATGAGG AGTAGTGTrA GGAAGGGGCT AACTTI=C T~cTTGCT7C TCTrrITAT CTCACCTrGCC CCTCCCCTIG TATCCCTTC T TCCIr=CC =TICC=lT TrGTCCTCAC 7rCATrCGTG CATC=TTCT GATTCCTCTT ACC-17GCTAA AAGGAGAAGT TrG1TGGGT ATCCTATATC AATGGCAGGA AGG'TGTI CT7C1T1ACC 'ITTATCCTAT Ac3ATrCATAT TCTCAACACC AACCTrCCTCC TITICAG'IT TCCTITTTTGC FrCTCTTGAC ACCACAGAGT T7GCAGCTAG TACT7GGAGA GGAAAATTAA ACAGAGATAC TI1XGACCAAG AGTAAGATGA AGAAAGTCTrA AACAACAGTA TAGTCTATAG TGGCAAGAGA GAGTATGGGG GCTGMTAGC CAGGGTGGCT GTACATAAAG TATATCTI'CA G'IMATATAA ACTGCTrATA GATGGAAATC AGAAAA'TrA AA FrTCT=A ACTGTCCAAG AAAAT'C TCA 7FITITCAAA 'ITGGGACTG ATAAATGTGA CCAGT-fCTGC 17ACTGTCCA 'FrGCCTGAAA TGGAGCI=G AGGTGGACTG TATAATITCT TCAATCTTAA CTrCCAAATrC TGATCAGCGA CGCCCTCTGC TGTTCACTAT TAATATI7AT T7ACCAATCA AAGTAAAGTA TwTGAAGTFI CCTGGCAGT7 rCAC'IMGT GTITAGTCC A'IMAGGCTG CTATAACAAA ATCCCIrTAAA CTGGGTAAGG GATATAAAT ATTAGAAA'Fr TATCTCTCAC AGTrCTGGAA GCTGGGAAGC CCAATATCAA GGCACCAGTA GA'T7GGTGT CTAACGAGGG TGTGCCGTCT GCTCAAAAA TGGCCCCTG 'FrGCTGCATC CTCACTTAGT GCAAGGGGCA AGACAGCTCC C'FCAACCrC =F~ATAAGG GCACTrATGT CA'TrCATGAG GGCAGAGCCC TCATGA=~A ATCA=~CCC CAAAGGCCCC WO 00/09525 PCT/US99/1 7712 EPI-109 74 ACCTC'ITAAT AGTATCACAT TGGGTGTrAG GTGTCTGGGA GGACACCAAT CrTCAAGCCA TATCATCTCA CI17GGAAAAA AGTCAAAATA AAACCAGTAG A'TrAATrAA TATTACACTA TTTATAGAAG CATGTGATGT ATCA'ITFCC GTA FrAAT~ CCTGGGGTTFG CCGTAACAAG TTACCACAAA CTAGGTGGCT TAAAACAATA GAAT1Tr CTCTCACATT TcTAGAGGCA GAAGTTFCACA GTGTGTCAAT AGGGCCATGT TCrCTGGAAG GC1TAGGGG AGAATATATTr TCATATCTF crAGcr CTCGGTGTCA CTGGCAATCC ITAGC'ACT 'rrGGC=CT GTGTCITCAC ATCATCTI= TATAAGAACA CCAGTGATAG TGATrAAGGG CATACCTrAC M~AATATGA CCTCATCTTA ACTAAT7ATG T=rCAATAA CCCTATTCC AAATAAGGCC ACA'ITCTGAA GTAT7GGGAG T7AGAACTFA AAGCTIT=G GGAGGGACAC AGTTCAACCC ATAACAACCC CTAAAATCGA TA ITATrCT CAATrAAGTC TTGAAATrGG ITCAAAAAG AGAATATTCT ATrAGAG=~ TFAATGTATA G=ITAACAT ATAGT=~ AGCCCCCAAT 'mT~rr T7Trrrr TflTIITLT 7FT=GAGAC GGAGTCTCGC TCTGTCGCCC AGGCCGGACT GCGGACTGCA GTGGCGCAAT CTCGGCTCAC TGCAAGCTCC GCT~rCCCGGG TTCACGCCAT TCCCCTGCcTr CAGCCTCCCG AGTAGCTGGG ACTACAGGCG CCTGCCACCG CGCCCGGCTA ATTITIGT A TITTAGTA GAGACGGGGT TrCACCI17GT TAGCCAGGAT GGTCTCGATC TCCTGACCTC ATGATCCACC CGCCTCGGCC TCCCAAAGTG CTGGGATTAC AGGCGTGAGC CACCGCGCCC GGCCTGCCCC CAATTAM1A GTI=CTAT AAACAGGGAA ATITAnITGT GTGGCCCrTA GAACTAATTT AATICCACr CTrAA ICCTA CI12ATG1TI7A TATAATGCTr T7AGAAATF GTA'rAT7CA GAAAATAAAC ATATACTATT GTATCTG77G CCTACACTA GAT=IAT7G CCTGCTATAT 'TAAA IrA TrAGTATIT AA7I7GT1TA T7AAAGAAAG AATGTGCCTG TAATCTCAGC AC'IrGAGA GGCCAAGGCA GAAGGATTGC 'rGAGCCCAG GAGTITGAGA CCAGACTGAG CAACACAGGG AGACCCCCAT CTCTACAAAA AATAAAAAAA TrCTCCAGGC CTCATGGCAC ATACCTGTAG TTCTAGTTAC TTGGGAGACT GGGGTGGGAG GATGCATTGA GCCCAGGAGA TrGAcIGCTGC AGTGAGCCAT GATCAGGCCA CTGTACTCCA GC~rGGACAA CAGAGTGAGA G=TGTCrAG ATAGATAGAT AGATAGATAA TCTAAATAGA TAATAGACAG ATTATCTAAA TAGATAATAG ACAGATTATC TAAATAGATA ATAGACAGAT TATCTAAATA GATAATAGAC AGATTATCTA AATAGATAAT AGACAGATTA TC17AAATAGA TAATAGACAG ATTATCTATC TAAATAGATA ATAGAT7ATC TAAATAGATA ATAGATAGAT AGATrAGATA GATAGATAGA TAGATAGAGC TTGGACAACA GAGTGAGAGC CTGTCTAGAT AGATAGAAAC AAAGAAAGAA AGAAAGAATG GTGCTCATAT TT7AAAGCAT TGAAAAATGG TCT7CCTTGC TTATATTACC CACACCTrCT 'TGTTGGCAT TAAGATGCAA ACTIGTI AAACAGTI7GA GTAAATCAAA GATGGGACTG 'I1AAGTrTAFT TGTGTrAT-F ACCTGCT1T TGAAAATGTA AAAATAAAAC TCTAGGTT-rA A'ITAGTAGTA TGCTATr7AG TAATGAAGTA AAGCTAGAGG CTrCGAACAA ATCTIGTGTA AMFCCTCTr GAATGAGAGA GAAAAM~AA AGTAAGCAAA CAAATAAGTr GTGTGTCACC ACTCATTCAG TCATTrAACA AGTATFrCCA GAGTA=TAT TCTGTGCCAG GAAATGTrGT AGGTGCCCTC AACAACTrAG AGTCTAGCCT GAGACACAAG TAAGTAGGTA AT7AT7ATAG AATGGTATGA TCTIGGAGG ACTGGGTA1TF GGCTGGCTCA TGGGAGTACA AGATAGGTAC CCAGTGATGA AGTCAGGAAA GGTI7CT7AT GGTGATATGA TGACGTCTAT GCTGATTATA AGGTCAGTGT AGAATAAACT TTGTGCTIT AAAMhGCAT AGCACTGTAT TAGAGAGITC ATCTTCAAAA TAATCGAAAA GGCTGAGTGT GGTGACCCAT GGCTGTAATC CCAGCACTI GGGAGGCCGA GGTGGGCAGA 'rTGCTrGAGC TAGGAGUTCG AGACCAGGCTr GGCCAACATG GTGAAACCCC GTCTCTACTA AAAATACAAA AATrAGCCAG GAGTGATGGT GCGCACCTGT AATGCCAGCT ACTrGGGAGG CTGAGGCAGG AGGATCACTT GAACCCAGGA GGTGGAGGTr GAAGTAAGCC GAGGTCATGC CACTGCACTC CAGCCTGGGC AACAGAGTGA GACTCCATCT CAAAAAAAAA AAAAATGATC AAAGAAAGGT GAA=IICAT CrACCCTATI7 TCTGCTGAGG AAAATGGACT ATITCAAAT AT=TAATA AGGGTCAAAA TGAGGGATC GCA'TTIC AAGTITATG A'TAITTAA CTGTGGAAC AAAAATAAAC CAGAAACCAC CACCTCTCAC GCCAAAGCTC ACACC'ITCAG CCTCCAACAT GAAGGTCTCC GCAGCAC17TC TGTGGCTGCT GCTCATAGCA GCTGCCTTCA GCCCCCAGGG GCTCGcTGGG CCAGCTrCTG TCCCAACCAC CTGCrGCF= AACCTGGCCA ATAGGAAGAT ACCCCTrCAG CGACTAGAGA GCTACAGGAG AATCACCAGT GGCAAATGTC CCCAGAAAGC TGTGATCTrC AAGACCAAAC TGGCCAAGGA TATCTrGTGCC GACCCCAAGA AGAAGTGGGT GCAGGA'I7CC ATGAAGTATC TGGACCAAAA ATCTCCAACT CCAAAGCCAT AAATAATCAC CATITIGAA ACCAAACCAG AGCCTGAGTG TrGCCTAA'Fr TGT=VCCCT TCTrACAATG CATTCTGAGG TAACCTCA'IT ATCAGTCCAA AGGGCATGGG TInrATrATA TATATATATA 'rMT =~ AAAAAAAAAC GTATTGCATT TAA'T17ATT7G AGGCI=AAA ACT1TATCCTC CATGAATATC AGTrATIT AAACTGTAAA GC1TGTGCA GATT=AC CCCCTGGGAG CCCCAA'T7CG ATCCCCTGTC ACGTGTGGGC AATGTTCCCC CTCTCCrCTC 7FCCTCCCTG GAATCTGTA AAGGTCCTGG CAAAGATGAT CAGTATGAAA ATGTCA'FrGT TCTTGTGAAC CCAAAGTGTG ACTCATTAAA TGGAAGTAAA TGTTG=IFA GGAATAC ATGAAGGTCT CCGCAGCACT TCTGTGGCTG CTGCTCATAG CAGCTGCCTT CAGCCCCCAG GGGCTCGVITG GGCCAGC-I7C TGTCCCAACC ACCTGCTGCT TTAACCTGGC CAATAGGAAG ATACCCCTJ7C AGCGACTAGA GAGCTACAGG AGAATCACCA GTGGCAAATG TCCCCAGAAA GCTGTGATCT TCAAGACCAA ACTGGCCAAG GATATCTGTG CCGACCCCAA GAAGAAGTGG GTGCAGGA17 CCATGAAGTA TCTGGACCAA AAATCTCCAA C7CCAAAGCC ATAA CCACATATTC CCCTCCT1T CCAAGGCAAG ATCCAGATGG ATTAAAAAAT GTACCAAGTC CCTCCTACTA GC=GCCTCT CTCTGTTCT GCTrGACTTC CTAGGATCTG GAATCTGGTC AGCAATCAGG AATCCCTTCA TCGTGACCCC CGCATGGGCA AAGGCTrCCC TGGAATCTCC CACACTGTCT GCTCCCTATA AAAGGCAGGC AGATGGGCCA GAGGAGCAGA GAGGCTGAGA CCAACCCAGA AACCACCACC TCTCACGCCA AAGCTCACAC CTCAGCCTC CAACATGAAG GTCTCCGCAG CACTCTGTG GCTGCTGCTC ATAGCAGCTG CCTrCAGCCC CCAGGGGCTC GCTGGGCCAG GTAAGCCCCC CAACTCCIA CAGGAAAGGT AAGGTAACCA CCTCCAGGCT ACTAGGTCAG CAAGAATCT TACAGACTCA CTGCAAA'rrC TCCATITGAA AAATAGGGAA ACAGG=IIG TGGGTGGACA AGAAATGCCT CAACCGTCAC ATCCAGTCAC TGGAAGAGCC AGAACTAGAA AGCTCCCGAG TCT1TCCCC ACATTCAAGA GGGCCGCTGG GTGCATCCT ACCCAGCTAT CCTrACAGTG T'17GGGAATG GGGAATGGCT CTGTCrrACT GTGGGCATGG TGGGCAT1T TGGCAGTGGG AGAGAAGGAA AATCTGT7GA FrAGAAGCTC AGTATGTTAA FTCGACTCCA GGACAGCFI CAGAGACAGT GGCTAAGAGA AGAACGAGGT CCCAGGGGAT C~TMGAGGT GACTI'A1T1 GACACTC1T GGGAAAGTrA TCTAGGAGAT TrGT7CCATA ACTCATITC CCATACTCTG GTGACAAATT TACTGAGTGT ATCGGTCCCA CTGAGCCAGT GCATAGCATG GTAACAAACA GTrCTAAAYr ATCAATGACT TAACAGAATT AACTAAATFA ACAAAAGTTA CI=CTCACT TGTACTAAAT ATCTATAATG TATGGGCTCA GGCTrGCA =F~ATACTC AGGATrCTAG ACTGATGGAG AAGUrGCCAT GTGGGGGAAC ArrGATGGAT ACTGTGATAA AGCAGAAGAA AGCTCTCAGG AGTCTGCAT AGGCAATGCA CTGTGGCTCA AAAATGACAC CCATCAC1T GTCTrCC=CT TTA17GATCA AAACTAATTA ATGCCTCCAA CCAAACAAAA GTGGCCAAGA AATGCAAGTC TACCIGTGT CTCAAAACAG AGGATGGAGA ATA'TrTGGTG AAAATTACCA TGACCATCAC ATGGCCACGT AGGTC1TAT AATGACAGAG CTAGCATG TCACATTGAC CAAGCI=GT CCATACACTC TACAGTAATG ATGAGTCCTC AGTGCACAGG GGAGGATGCT GAAGACACAG GACAGCATCC TCCAGACACA TAAGACTrCA GAGCAGAGGG ATTCTCCCTC CACCTCTCGC AATCC'IGC =TCrCCTAA CTTCC1TAC AAAGTCATGC 17GGAAATGT CTATGTATCA TCATGTGGCT CATTITIC TCTG FTCA717 TITCCCC AAAATrCAGC TTCTGTCCCA ACCACCTGCT GCT=AACCT GGCCAATAGG WO 00/09525 PCT/US99/17712 tpi-U9 75 AAGATACCCC TTCAGCGACT AGAGAGCTAC AGGAGAATCA CCAGTGGCAA ATGTCCCCAG AAAGCTGTGA TGTAAGTAAA TAAAGTI'CAC CCTCCCCTAG ACAAAAAAAT AATGTCrAGG GCACAGAGTC AAGAACTGTG GGAGTCATAG ACTCTGATAG MTGACCTCT ATGGTCCAAT TCATTAA'Tr TCACAAGTGA GTGTTCACTC CCAGCTCCCT GCCTGGGAGA T'TGCTGTAGT CATATCAATT TCTI'CAAGTC AAGAGCAAAG ATGG=FTAC TGGGCCTTA AGAGCAGCAA CTAACCCAAG AGTCTCATCC 'FrCCTCCrCT CCGTAGCAAC C=r~GTCCA GGGGCAGATG GTCCTAAAT A ITAGGGTC AAATGGGCAG AA TI17CAAA AACAATCCT CCAATrGCAT CCrGATrCTC CCCACAGCTT CAAGACCAAA CTGGCCAAGG ATATCTGTGC CGACCCCAAG AAGAAGTGGG TGCAGGAT7C CATGAAGTAT CTGGACCAAA AATCTCCAAC TCCAAAGCCA TAAATAATCA CCATITIGA AACCAAACCA GAGCCTGAGT GTTGCCTAAT rG'TrCCC T7CTrACAAT GCATTCTGAG GTAACCTCAT TATCAGTCCA AAGGGCATGG GTITrFAT ATATATATAT ATATATI1T =FTAAAAAA AAACGTATTG CAM~AA TT ATrGAGGCTT TAAAACTTAT CCTCCATGAA TATCAGTT1AT TITAAACTG TAAAGCITG TGCAGAT7CT TTACCCCCTG GGAGCCCCAA TTCGATCCCC TGTCACGTGT GGGCAATGTr CCCCCTCTCC TCTCTTCCTC CCTGGAATCT TGTAAAGGTC CTGGCAAAGA TGATCAGTAT GAAAATGTCA TTGTTCTI7GT GAACCCAAAG TGTGACTCAT TAAATGGAAG TAATGT7GTT T-rAGGAATAC ATAAAGTATG TGCATA=II ATTATAGTCA CTAGTrGTAA 'TTITGTG GGAAATCCAC ACTGAGCTGA GGGGG GCCAGGTCGC TGTI'GGTCCA CGCCGCCCGT CGCGCCGCCC GCCCGCTCAG CGTCCGCCGC CGCCATGGGA GGCCGGAGCC GAGCCGGGGT CGGGCAGCAG CAGGGACCCC CCAGAGGCGG GGCCTGTGGG ACCGCTATGG GCGTGGAGAT CGAGACCATC TCCCCCGGAG ACGGAAGGAC ATrCCCCAAG AAGGGCCAAA CGTGTGTGGT GCACTACACA GGAATGCTCC AAAATGGGAA GAAGM]GAT TCATCCAGAG ACAGAAACAA AC=T1CAAG 'ITCAGAAT7G GCAAACAGGA AGTCATCAAA GG=1IGAAG AGGGTGCAGC CCAGATGAGC TTGGGGCAGA GGGCGAAGCT GACCTGCACC CCTGATGTGG CATATGGAGC CACGGGCCAC CCCGGTGTCA TCCCTCCCAA TGCCACCCTC ATCT=GACG TGGAGCTGCT CAACT7AGAG TGAAGGCAGG AAGGAACTCA AGGTGGCTGG AGATGGCTGC TGCTCACCCT CCTAGCCTGC TCTGCCACTG GGACGGCTCC TGCTITGGG GCTCT~rGATC AGTGTGCTAA CCTCACTGCC TCATGGCATC ATCCAT7CTrC TCTGCCCAAG TTGCTCTGTA TGTGTTCGTC AGTGTTCATG CGAA'r=C'1G =TGAGGAAA CTTCGGT1TGC AGA'FrGAAGC A=ICAGG~Fr GTGCA=IIG TGTGATGCAT GTAGTAGCCT TTCCTGATGA CAGAACACAG ATCT=TT~I CGCACAATCT ACACTGCCT ACCTTCA=T AAACCACACA CACAAGGTGC TCAGACATGA AATGTACATG GCGTACCGTA CACAGAGGGA CTGAGCCAG T7rACCTTGC TGTCAC'=C TCTCTrATAA ATIrT!GF1AG CTGCTCACTT AAACAATGTC CTCT=GAGA AAATGTAAAA TAAAGGCTCT GTG=TGACA GAATrCGGGC CGCCGCCAGG TCGCTGTFGG TCCACGCCGC CCGTCGCGCC GCCCGCCCGC TCAGCGTCCG CCGCCGCCAT GGGAGTGCAG GTGGAAACCA TCTCCCCAGG AGACGGGCGC ACCTTCCCCA AGCGCGGCCA GACCTGCGTG GTGCACTACA CCGGGATGCT TGAAGATGGA AAGAAA'IMG IT7CCTCCCG GGACAGAAAC AAGCCCT=A AGTrrATGCT AGGCAAGCAG GAGGTGATCC GAGGCTGGGA AGAAGGGGT7 GCCCAGATGA GTGTGGGTCA GAGAGCCAAA M~ACTATAT CTCCAGA'TrA TGCCTATGGT GCCACTGGGC ACCCAGGCAT CATCCCACCA CATGCCACTC TCGTCTTCGA TGTGGAGCTT CTAAAACTGG AATGACAGGA ATGGCCTCCT CCC11AGCrC CCTGT7CTrG GATCTGCCAT GGAGGGATCT GGTGCCTCCA GACATGTGCA CATGAGTCCA TATGGAGCTI' TFCCTGATGT TCCACTCCAC ITGTATAGA CATCTrGCCCT GACTGAATGT GTTCTGTCAC TCAGCT=GC 'rCCGACACC TCTGTTCCT C=CCCCI= CTCCTCGTAT GTGTG'1AC CTAAACTATA TGCCATAAAC CTCAAGTTAT TCATF=ATI' rTT CAT ITGGGGTGA AGA FrCAG~r TCAGTC'I= GGATATAGGT TTCCAATTAA GTACATGGTC AAGTATTAAC AGCACAAGTG GTAGGTTAAC ATrAGAATAG GAATTrGGTGT TGGGGGGGGG G=~GCAAGA ATATI=ATT TrAATIr'I GGATGAAAT7 FTrATCTA'IT ATATATrAAA CA FFCTGCT GCTGCGCTGC AAAGCCATAG CAGAMrGAG GCGCTGTTGA GGACTGAATI7 ACTCTCCAAG TTIGAGAGATG TC'=GGGT7 AAATrAAAAG CCCTACCTAA AACTGAGGTG GGGATGGGGA GAGCC1TGC CTCCACCAT7 CCCACCCACC CTCCCCTTAA ACCCTCTGCC TTGAAAGTA GATCATGTTC ACTGCAATGC TGGACACTAC AGGTATCTGT CCCTGGGCCA GCAGGGACCT CTGAAGCCTT CIGTGGCC TTTmrrrr T'rCATCCTGT GG'IFICTA ATGGACTIC AGGAA=F~G TAATCTCATA ACI=CCAAG CTCCACCACT TCCTAAATCT TAAGAACI= AATGACAGT TrCAATTGAA GGTGCTGTr7 GTAGACI1FAA CACCCAGTGA AAGCCCAGCC ATCATGACAA ATCCTrGAAT crTrTCT=AA GAAAATGATG CTGGTCATCG CAGC'FrCAGC ATCTCCTGTT 'I=GATGCT TGGCTCCCTC TGCTGATCTC AG=~CCTGG CTITCCTCC CTCAGCCCCT TCTCACCCCT T7rGCTGTCCT GTGTAGTGAT T'TGGTGAGAA ATCGT7GCTG CACC=TCCC CCAGCACCAT 'FrATGAGTCT CAAGTITAT TATTGCAATA AAAGTGCTT ATGCCCGAAT TC GCCGCCGCCA TGGGAGTGCA GGTGGAAACC ATCTCCCCAG GAGACGGGCG CACCTI'CCCC AAGCGCGGCC AGACCTGCGT GGTGCACTAC ACCGGGATGC TTGAAGATGG AAAGAAATM GATrCCTCCC GGGACAGAAA CAAGCCC'= AAGMIIATGC TAGGCAAGCA GGAGGTGATC CGAGGCTGGG AAGAAGGGGT TGCCCAGATG AGTGTGGGTC AGAGAGCCAA ACTGACTATA TCTCCAGAT7 ATGCCTATGG TGCCACTGGG CACCCAGGCA TCATCCCACC ACATGCCACT CTCGTC77CG ATGTGGAGCT TCTAAAACTG GAATGACAGG AATGGCCTCC TCCCT-rAGCT CCCTGTTC1T GGATCTGCCR TGGAGGGATC TGGTGCCTCC AGACATGTGC ACATGARTCC ATATGGAGCT TCCTGATG TrCCACTCCA CTTGTATAG ACATCTGCCC TGACTGAATG TGTrCTGTCA CTCAG='~G CTICCGACAC CTCTGT'17CC TC'1rCCCCT7 TCTCCTCGTA TGTGTGTTFA CCTAAACTAT ATGCCATAAA CCTCAAGTrA T7CA AAGCTTCTAC CCTAGTCTGG TGCTACACT7 ACATrGCITA CATCCAAGTG TGGTTAMIC TGTGGCTCCT GTTATAACTA ITATAGCACC AGGTCTATGA CCAGGAGAAT TAGACTGGCA TTAAATCAGA ATAAGAGAT7 T7GCACCTGC AATAGACCTT ATGACACCTA ACCAACCCCA TrAITTACAA TTAAACAGG3A ACAGAGGGAA TAC1TATCC AACTCACACA AGCTGTI]C CTCCCAGATC CATGC'T1T TGCG ITY ATITITAGA GATGGGGGCT TCACTATG17 GCCCACACTG GACTAAAACT CTGGGCCTCA AGTGATTGTC CTGCCTCAGC CTCCrGAATA GCTGGGACTA CAGGGGCATG CCATCACACC TAGTTCAT17 CCTCTATITA AAATATACAT GGCTrAAACT CCAACTGGGA ACCCAAAACA 'FICATIGCT AAGAGTCTGG TGTTCTACCA CCTGAACTAG GCTGGCCACA GGAATTATAA AAGCTGAGAA ATrCITAAT AATAGTAACC AGGCAACATC AflGAAGGCT CATATGTAAA AATCCATGCC TTCC1TCTC CCAATCTrCCA TrCCCAAACT TAGCCACTGG T7CTGGCTGA GGCCTI'ACGC ATACCTCCCG GGGCTrGCAC ACACCTT~Y CTACAGAAGA CACACC11GG GCATATCCTA CAGAAGACCA GGCTTrCTC TGGTCCT7GG TAGAGGGCTA CF=ACTGTA ACAGGGCCAG GGTGGAGAGT TCTCTCCTGA AGCTCCATCC CCTCTATAGG AAATGTGT7FG ACAATATI7CA GAAGAGTAAG AGGATCAAGA CT=1TGTG CTCAAATACC ACTGTTCTCT TCTCTACCCT GCCCTAACCA GGAGCTrGTC ACCCCAAACT CTGAGGTGAT TTATGCCT'TA ATCAAGCAAA CTTCCCTCTT CAGAAAAGAT GGCTCA'F= CCCTCAAAAG 'TGCCAGGAG CTGCCAAGTA T]rC7GCCAAT TCACCCTGGA GCACAATCAA CAAATTCAGC CAGAACACAA CTACAGCTAC TATTAGAACT AT7ATA17A ATAAATrCCT CTCCAAATCT AGCCCCTTGA CTCGGATf7 CACGATIWI CCCTrCCTCC TAGAAA=TG ATAAG2T1rCC CGCGCTTCCC TFITCTAAG ACTACATG'T TGTCATCT7A TAAAGCAAAG GGGTGAATAA ATGAACCAAA TCAATAACTT CTGGAATATC TGCAAACAAC AATAATATCA GCTATGCCAT CTICACTAT 'IrrAGCCAGT ATCGAGTTGA ATGAACATAG AAAAATACAA AACTGAATrC rrCCCTGTAA A'FrCCCCG~r TITGACGACGC ACTTGTAGCC ACGTAGCCAC GCCTACTAA GACAAUTACA WO 00/09525 PCT/US99/17712 EPI-109 76 AAAGGCGAAG AAGACTGACT CAGGCTTAAG CTGCCAGCCA GAGAGGGAGT CAITICATTG GCG'I=GAGT CAGCAAAGGT A I1XTCCTCA CATCTCTGGC TATTAAAGTA T1TCTGT7G TrGTTCT CTTGGCTr3T 'T7CTCTCAC ATrTGCCTTCT CTAAAGCTAC AGTCTCTCCr TTCTITCIT GTCCCTCCCT GG TffGGTAT GTGACCTAGA ATTACAGTCA GA=rCAGAA AATGATITCTC TCNI=rGCT GATAAGGACT GA11rCG=11 ACTGAGGGAC GGCAGAACTA GMTCCTATG AGGGCATGGG TGAATACAAC TGAGGCTTCT CATGGGAGGG AATCTCTACT ATCCAAAATl ATTAGGAGAA AATTGAAAAT 'rTCCAACrCT GTCTCTCTCT TACCTCTGTG TAAGGCAAAT ACCITAITC7 TGTGGTG'TTr flGTAACCTC TrCAAACTI CATTGATTGA ATGCCTG~rC TGGCAATACA 7rAGGTTGGG CACATAAGGA ATACCAACAT AAATAAAACA TTCTAAAAGA AGTITACGAT CTrAATAAAGG AGACAGGTAC ATAGCAAACT AATTCAAAGG AGCTAGAAGA TGGAGAAAAT GCTGAATGTG GACTAAGTCA 'FrCAACAAAG TITCAGGAA GCACAAAGAG GAGGGGCTCC CCTCACAGAT ATCTGGATrA GAGGCTGGCT GAGCTGATGG TGGCTGGTGT TCTCTGTTGC AGAAGTCAAG ATGGCCAAAG TTCCAGACAT GT]TGAAGAC CTGAAGAACT GTFACAGGTA AGGAATAAGA MFATCTCT7 GTGATTFAAT GAGGGTITCA AGGCTCACCA GAATCCAGCT AGGCATAACA GTG3GCCAGCA TGGGGGCAGG CCGGCAGAGG ITrGTAGAGAT GTGTACTAGT CCTGAAGTCA GAGCAGG'rrC AGAGAAGACC CAGAAAAACT AAGCATTCAG CATGTTAAAC TGAGATI'ACA TFGGCAGGGA GACCGCCAT7T 'TAGAAAAAT TA 1ITGAG GTCTGCTGAG CCCTACATGA ATATCAGCAT CAACTTAGAC ACAGCCTCTG TTGAGATCAC ATGCCCTGAT ATAAGAATGG G =ACTGG TCCAT7CTCA GGAAAACTrG ATCTCATTCA GGAACAGGAA ATGGCTCCAC AGCAAGCTGG GCATGTGAAC TCACATATGC AGGCAAATCT CACTCAGATG TAGAAGAAAG GTAAATGAAC ACAAAGATAA AAYI7ACGGAA CATATTAAAC TAACATGATG =~CCA'rrAT CTGTAGTAAA TACTAACACA AACTAGGCTG TCAAAAT1T GCCTGGATAT TMACTAAGT ATAAA11ATG AAATCTG1Tr TAGTGAATAC ATGAAAGTAA TGTGTAACAT ATAATCTATT TGGTTAAAAT AAAAAGGAAG TGCUFCAAAA CCT=CITT1T CTCTAAAGGA GCTfAACATT CTTCCCTGAA CT7CAATTAA AGCTCTIrCAA TTrGT-rAGCC AAGTCCAATT T17ACAGATA AAGCACAGGT AAAGCTCAAA GCCTGTCTI'G ATGACTACTA ATrCCAGA'rr AGTAAGATAT GAATTACTCT ACCTATGTGT ATGTGTAGAA GTCCTTAAAT TCAAAGATG ACAGTAATGG CCATGTGTAT GTGTGTGACC CACAACTATC ATGGTCAT-TA AAGTACATTG GCCAGAGACC ACATGAAATA ACAACAAT-fA CATTCTCATC ATCTT= GACAGTGAAA ATGAAGAAGA CAGT7CCTCC A7rGATCATC TGTCTCTGAA TCAGGTAAGC AAATGACTGT AAITrCTCATG GGACTGCTAT TCTTACACAG TGG1TIT7C ATCCAAAGAG AACAGCAATG ACTGAATCT TAAATAC'T1 TGTFIACCC TCACTAGAGA TCCAGAGACC TGTCTFCAT TATAAGTGAG ACCAGCTGCC TCTCTAAACT AATAGTI'GAT GTGCATTGGC TTCTCCCAGA ACAGAGCAGA ACTATCCCAA ATCCCTGAGA ACTGGAGTCT CCTGGGGCAG GCT7CATCAG GATGTTAG~r ATGCCATCCT GAGAAAGCCC CGCAGGCCGC T7CACCAGGT GTCTGTCTCC TAACGTGATG TGT7GTGGTr GTCTTCTCTG ACACCAGCAT CAGAGGTTAG AGAAAGTCTC CAAACATGAA GCTGAGAGAG AGGAAGCAAG CCAGCTGAAA GTGAGAAGTC TACAGCCACT CATCAATCTG TGYrATFGTG TrGGAGACC ACAAATAGAC ACTATAAGTA CTGCCTAGTA TGTCTTCAGT ACTGGC1TA AAAGCTGTCC CCAAAGGAGT AI=CTAAAA TATFIGAGC ATTGTrAAGC AGATflIAA CCTCCTGAGA GGGAACTAAT TGGAAAGCTA CCACTCACTA CAATCATrGT TAACCTA'TI7 AGTTACAACA TCTCArfTI GAGCATGCAA ATAAATGAAA AAGTCrrCCT AAAAAAATCA TC7IITATC CTGGAAGGAG GAAGGAAGGT GAGACAAAAG GGAGAGAGGG AGGGAAGCCT AATGAAACAC CAGTrACCTA AGACCAGAAT GGAGATCCTC CTCACTACCT CTGTrGAATA CAGCACCTAC TGAAAGAACT TrCAT'rCCCT GACCATGAAC AGCCTCTCAG CT7rTGTI= CCC7CAC AGAAATCCTr CTATCATGTA AGCTATGGCC CACTCCATGA AGGCTGCATG GATCAATCTG TGTCTCTGAG TATCTCTGAA ACCTCTAAAA CATCCAAGCT TACCTTCAAG GAGAGCATGG TGGTAGTAGC AACCAACGGG AAGGT7CTGA AGAAGAGACG GT-rGAGTI17A AGCCAATCCA TCACTGATGA TGACCTGGAG GCCATCGCCA ATGACTCAGA GGAAGGTAAG GGGTCAAGCA CAATAATATC TrrCT=rAC AGTIIAAGC AAGTAGGGAC AGTAGAATI7r AGGGGAAAAT TAAACGTGGA GTCAGAATAA CAAGAAGACA ACCAAGCAfl AGTCTGGTAA CTATACAGAG GAAAA7FAAT =ITATCCT7 CTCCAGGAGG GAGAAATGAG CAGTGGCCTG AATCGAGAAT ACTrGcTCAC AGCCATrATT TCTFAGCCAT ATrGTAAAGG TCGTGTGACT 'FrAGCC=r CAGGAGAAAG CAGTAATAAG ACCACTTACG AGCTATGTrC CTCTCATACT AACTATGCCT CCTGGTCAT GTrACATAAT CTITCGTGA 'FrCAGTrTCC TCTACTGTAA AATGGAGATA ATCAGAATCC CCCACTCATI' GGAT7GTFGT AAAGATI'AAG AGTCTCAGGC 'F=ACAGACT GAGCTAGCTG GGCCCTCCTG ACTGTrATAA AGA'FrAAATG AGTCAACATC CCCTAACTTC TGGACTAGAA TAATGTCTGG TACAAAGTAA GCACCCAATA AATGflAGCT ATFIACTATCA TrATrATTAT TA=I~ATT7 r~fmT=G AGATGGAGTC TGGCTCTGTC ACCCAGGCTG GAGTGCAGTG GCACAATCTC GGCTCACTGC AAGCTCTGCC TCCTGGGTTC ATGCCATFCT CCTGCCTCAG CCTCCCGAGT AAGCTGGGAA TACAGGCACC CGCCACTGYI' CCCGGCTAAT T1TGTAT7 TTTAGTAGAG ACGGAGfTT7C ACCGTGGTCT CCATCTCCTC GTGATCCACC CACCIGGCC TCCCAAAGTG CCGGGATTAC AGGCGTGAGC CACCGCGCCC GGCCTATTAT TATrA~rA'Fr ACTACTACTA CTACCTATAT GAATACTACC AGCAATACTA AT7ATrAAT GACTGGATTA TGTCTAAACC TCACAAGAAT CCTACCTCT CA=~ACAT AAAAGGAAAC TAAGCTCATr GAGATAGGTA AACTGCCCAA TGGCATACAT CTGTAAGTGG GAGAGCCTCA AATCTAATTC AG'ITCTACCT GAGTAAAAAA ATCATGG 1T CTCCTCCATC C=1TACTGT ACAAGCCTCC ACATGAACTA TAAACCCAAT ATrCCTG1T TTAAGATAAT ACCTAAGCAA TAACGCATGT TCACCTAGAA GG7TrAAAA TGTAACAAAA TATAAGAAAA TAAAAATCAC TCATATCGTC AGTGAGAGTT TACTACTGCC AGCACTATGG TATG I=CCT TAAAATC7T GCTATACACA TACCTACATG TGAACAAATA TGTCTAACAT CAAGACCACA CTA ITTACAA C1TATATCC AGCT1TT11 AC77AGCAAT GTATTGAGGA CAT1TAGAG TGCCCGTIT TCACCATI'AT AAGCAATGCA ACAATGAACA TCTGTATAAA TAAATATrCA '1CTCTCAC CC=rA'IC =TAGAATAT A'ITCCTAGAA GTAGAATrC CCAGAGCCAT GAGGATIGT GACGCTATTG ATATGTGCCA =TGCACTrC TCTGTGACAT ATATAATTAT '1IAATGCA TTCATTIT TCTCAGAGTG CATTCGTI17G AAAACATAGA CGGGAAATAC TGGTAGTCTr CCT~rGTCAGT TAGAAACACC CAAACAATGA AAAATGAAAA AGTrGCACAA ATAGTCTCTA AAAACAATGA AACTATTGCC TGAGGAAT7G AAGTTrAAAA AGAAGCACAT AAGCAACAAC AAGGATAATC CTAGAAAACC AGTTCTGCTG ACTGGGTGAT TTCACTTCTC =fGCT'TCCT CATCTGGATT GGAATATrCC TAATACCCCC TCCAGAACTA =I~CCCTGT 7rGTACTAGA CTGTGTATAT CATCTGTGTT TGTACATAGA CATrAATCTG CACTTGTGAT CATGG=1IA GAAATCATCA AGCCTAGGTC ATCACCTI= AGC=CCTGA GCAATGTGAA ATACAAC=f ATGAGGATCA TCAAATACGA AT7CATCCTG AATGACGCCC TCAATCAAAG TATAAF1rCGA GCCAATGATC AGTACCTCAC GGCTGtTGCA TTACATAATC TGGATGAAGC AGGTACATTA AAATGGCACC AGACA 1TCT GTCATCCTCC CCTrCC1CA TTTACTTA~r TATTrA'IMC AAT=IICTG CTGCAAAAA ACATACCTCT TCAGAGTTCT GGG~rGCACA ATrCTTCCAG AATAGCTTGA AGCACAGCAC CCCCATAAAA ATCCCAAGCC AGGGCAGAAG GTTCAACTAA ATCTGGAAGT TCCACAAGAG AGAAGMTCC TATCT=GAG AGTAAAGGGT TGTGCACAAA GCTAGCTGAT GTACTACCTC TIGGTr TCAGACA ITC TTACCCTCAA TITAAAACT GAGGAAACTG TCAGACATAT TAAATGATT ACTCAGA'TTT ACCCAGAAGC CAATGAAGAA CAATCACTCT CC1TAAAAA GTCTGTTGAT CAAACTCACA AGTAACACCA AACCAGGAAG ATC TTA TCTCTGATAA CATAITGTG AGGCAAAACC TCCAATAAGC TACAAATATG GCTTAAAGGA WO 00/09525 PCT/US99/17712 EPI-109 77 TGAAGTTTAG TGTCCAAAAA CTITATCAC ACACATCCAA TITTCATGGC GGACATGTTT TAGTTTCAAC AGTATACATA T=TTCAAAGG TCCAGAGAGG CAAT=TGCA ATAAACAAGC AAGACLTT CTGATTGGAT GCACTTCAGC TAACATGCTT TCAACTCTAC ATACAAAT TATTTTGTGT TCTATTC TACTTAATAT TATTTCTGCA ATITTCCCAA TATTGACATC GTGTATGTAT TTGCCATT TAATATCACT AGACAATTCA ATCAGGTTGC TACGTTGGTC CCGGGTI ACTCTAAATA GCTTGATTGC AAATATCTTT GTATATATTA TrGTITITrC TCCTATCTTG TAATCTTT GAGCACATCC CAAAGAGGAA TGCCTAGATC AATGGGCACA AATAATTTGA CAGCTCTTAT TAAACATTAT TCTGTAAGTA AAAACTGAAC TAC'I1iCAG TATCACTAGC AACATATGAG TGTATCAGCT TCCTAAACCC CTCCATGTTA GGTCATTATG AACTTATGAT CTAACAAATT ACAGGGTCTT ATCCCACTAA TGAAATTATA AGAGATTCAA CACTTATTCA GCCCCGAAGG ATTCATTCAA CGTAGAAAAT TCTAAGAACA TrAACCAAGT ATITACCTGC CTAGTGAGTG TGGAAGACAT TGTGAAGGAC ACAAAGATGT ATAGAATTCC ATTrCCTGACT TCCAGGTATT TACACCATAG GTGGGGACCT AACTACACAC ACACACACAC ACACACACAC ACACACACAC ACCATGCACA CACAATCTAC ATCAACACTT GATMTATAC AAATACAATG AATTrACTTT CTITTGGTT CTTCTCTTCA CCAGTGAAAT TTGACATGGG TGCTTATAAG TCATCAAAGG ATGATGCTAA AATrACCGTG ATTCTAAGAA TCTCAAAAAC TCAATrGTAT GTGACTGCCC AAGATGAAGA CCAACCAGTG CTGCTGAAGG TCAGTTGTCC TTTGTCTCCA ACTTACCTTC ATTACATCT CATATGTTG TAAATAAGCC CAATAGGCAG ACACCTCTAA CAAGGTGACA CTGTCCTC17 TCCTTCCTAC CACAGCCCCC ACCTACCCAC CCCACTCCCA TTGATTCCAG AGGCGTGCCT AGGCAGGATC TATGAGAAAA TATAACAGAG AGTAAGAGGA AAATTACCTT CTCTIT CCTCCCTG CCTGACCITA TTCACCTCCC ATCCCAGAGC ATCCATTTAT TCCATTGATC 'TACTGACA TCTATTATCT GACCTACACA ATACTAGACA TTAGGACAAT GTGGCCTGCC TCCAAGAAAC TCAAATAAGC CAACTGAGAT CAGAGAGGAT TAATCACCTG CCAATGGGCA CAAAGCAACA AGCTGGGAGC CAAGTCCCAA AATGGGGCCT GCTGCTTCCA GTTCCCCTCT CTCTGCATTG ATGTCAGCAT TATCCTTCGT CCCAGTCCTG TCTCCACTAC CACTCCCC CTCAAACACA CACACACACA ACAGCCTTAG ATGTTTTCTC CACTGATAAG TAGGTGACTC AATTTGTAAG TATATAATCC AAGACCTTCT ATTCCCAAGT AGAATTTATG TGCCTGCCTG TGCTIT-CTA CCTGGATCAA GTGATGTCTA CAGAGTAGGG CAGTAGCTTC ATTCATGAAC TCATTCAACA AGCATTATTC ACTGAGAGCC TTGTA'mTT CAGGCATAGT GCCAACAGCA GTGTGGACAG TGGTGCATCA AAGCCTCTAG TCTCATAGAA CTTAGTCTTC TGGAGGATAT GGAAAACAGA CAACCCAAAC AACCAACAAA AGAGCAAGAT GCTGCAAAAA AAAAAAAAAT GAATAGGGTG CTAAGATAGA GAAAAGTGGG AGAGTGCTAT TTAGACAAAG TGGTAAAAAC AAAGCCCCTT GTGAGATGAG AGCTGCCGAC AGAGGGGGCG GGTCATGGTT GTGGGTFITi GGGTAGGACA TTCAGAGGAG GGGGCGGGTC GTGGTTGTGG G'IT ITIGGGT AGGACATTCA GAGGAGGGGG CGGGTCGTGG TTGTGGGTTT TTGGGTAGGA CATTCAGAGG AGGGGGCGGG TCGTGGTTGT GGGIT1IrGG GTAGGACATT CAGAGGAGGG GGCGGGTCGT GGTTGTGGGT TTTGGGACA TTCAGAGGAG TCTGAATGCA CCCAGGCCTA CAACTTCAAG ATGGTAAAGG ACAGCTCCAA GGATCAGAAG AAGCATTCT GGAACTGGGG CATTGAGA AGGAGGAAAA ATATGCAGAG ACTAGTGCTT GCAGAGCTTG CATTTGGATT TCATTTGAGG TACAATGAAA ACCCATTAAT GGGTTTCACA CAGTGCAATG GCCTGACCTC ACTTATATTT CCTAAAATAG AAAACAGATC AGAAGGAAGG CAATAGAGAA GCAGAAAGTC CAATGAGGAG GTTTCACAGC AGTCATGGGG GTGGGGTAAG GAAAAGAAGT GGAAAGAAAC AGACAGAATT GGGTTATATT TTGGAGATAG AACCAACAGA AGGAAGAGGA GAAACAACAT TTACTGAGAA GGGAAAAAGT AGGAGAGGAA TAGGTTTGGG AAATAAATCC TGCTGACATT GGAAACCCCA AGGAAGCCTC AAAAGTATAT TTACTTGCTr TAGATAAA AGAATAGGAA AGAAGCATCT CAACTTGGAA TTTGAAATCT ATi1TICCAT AAAAGTATTG TTAAATrCTA CTCATACTCA CAAGAAAAGT ACATTCTAAA GAGTATATTG AAAGAGTTTA CTGATATACT TAGGAATT GTGTGTATGT GTGTGTGTGT ATGTGTGTGT GTGTGTTAA CCTTCAATrG TTGACTTAAA TACTGAGATA AATGTCATCT AAATGCTAAA TTGATTTCCC AAAGGTATGA TTTGTTCACT TGGAGATCAA AATGTITAGG GGGCTTAGAA TCACTGTAGT GCTCAGATT GATGCAAAAT GTCTTAGGCC TATGTrGAAG GCAGGACAGA AACAATG1TT CCCTCCTACC TGCCTGGATA CAGTAAGATA CTAGTGTCAC TGACAATCTT CATAACTAAT TTAGATCTCT CTCCAATCAA CTAAGGAAAT CAACTCTTAT TAATAGACTG GGCCACACAT CTACTAGGCA TGTAATAAAT GCTTGCTGAA TGAACAAATG AATGAAGAGC CTATAGCATC ATGTTACAGC CATAGTCCTA AAGTGGTGTT TCTCATGAAG GCCAAATGCT AAGGGATTGA GCTTCAGTCC TITITCTAAC ATCTTGTTCT CTAACAGAAT TCT CTIT TCTTCATAGG AGATGCCTGA GATACCCAAA ACCATCACAG GTAGTGAGAC CAACCTCCTC TTCrCTGGG AAACTCACGG CACTAAGAAC TATTTCACAT CAGTTGCCCA TCCAAACTTG ATTATTGCCA CAAAGCAAGA CTACTGGGTG TGCTTGGCAG GGGGGCCACC CTCTATCACT GACTTTCAGA TACTGGAAAA CCAGGCGTAG GTCTGGAGTC TCACTTGTCT CACTTGTGCA GTGTTGACAG TTCATATGTA CCATGTACAT GAAGAAGCTA AATCCTTTAC TGTTAGTCAT TTGCTGAGCA TGTACTGAGC CTTGTAATfC TAAATGAATG TACACTCT TTGTAAGAGT GGAACCAACA CTAACATATA ATGTTGTTAT TTAAAGAACA CCCTATATTT TGCATAGTAC CAATCATIT AATTATTATT CTTCATAACA ATTTTAGGAG GACCAGAGCT ACTGACTATG GCTACCAAAA AGACTCTACC CATATTACAG ATGGGCAAAT TAAGGCATAA GAAAACTAAG AAATATGCAC AATAGCAGTT GAAACAAGAA GCCACAGACC TAGGATTTCA TGATCATT TCAACTGTTT GCCT7CTGCT TTTAAGTrGC TGATGAACTC TTAATCAAAT AGCATAAGTT TCTGGGACCT CAGTITTATC ATiTTCAAAA TGGAGGGAAT AATACCTAAG CCTTCCTGCC GCAACAGTTT TITATGCTAA TCAGGGAGGT CATTGGTA AAATACTTCT CGAAGCCGAG CCTCAAGATG AAGGCAAAGC ACGAAATGTT AFI1-rAAT TATTATTTAT ATATGTAIT ATAAATATAT TTAAGATAAT TATAATATAC TATAMTTATG GGAACCCCTT CATCCTCTGA GTGTGACCAG GCATCCTCCA CAATAGCAGA CAGTGTTC TGGGATAAGT AAG'TGATT TCATTAATAC AGGGCATT GGTCCAAGTT GTGCTTATCC CATAGCCAGG AAACTCTGCA TTCTAGTACT TGGGAGACCT GTAATCATAT AATAAATGTA CATTAA1TAC CTTGAGCCAG TAATrGGTCC GATCTTTGAC TCITITGCCA TTAAACTAC CTGGGCATTC TTGT1TCATT CAATTCCACC TGCAATCAAG TCCTACAAGC TAAAATTAGA TGAACTCAAC TTTGACAACC ATGAGACCAC TGTTATCAAA ACTTTCTIT CTGGAATGTA ATCAATGTTT CTTCTAGGTT CTAAAAATrG TGATCAGACC ATAATGTTAC ATTATTATCA ACAATAGTGA TTGATAGAGT GTTATCAGTC ATAACTAAAT AAAGCTrGCA ACAAAATTCT CTGACACATA GTTATTCATT GCCTTAATCA TTATTTACT GCATGGTAAT TAGGGACAAA TGGTAAATGT TTACATAAAT AATTGTATTT AGTGTTACTT TATAAAATCA AACCAAGATT TTATAT1ThT TTCTCCrCTT TGTTAGCTGC CAGTATGCAT AAATGGCATT AAGAATGATA ATATTTCCGG GTTCACTAA AGCTCATATT ACACATACAC AAAACATGTG TTCCCATCTT TATACAAACT CACACATACA GAGCTACATT AAAAACAACT AATAGGCCAG GCACGGTGGC TCAGACCTGT AATCCCAGCA CTTGGGAGG ACCAACCTCT TCGAGGCACA AGGCACAACA GGCTGCTCTG GGATTCTCTT CAGCCAATCT TCATTGCTCA AGTGTCTGAA GCAGCCATGG CAGAAGTACC TGAGCTCGCC AGTGAAATGA TGGCTrA'1A CAGTGGCAAT GAGGATGACT TGTTCTTGA AGCTGATGGC CCTAAACAGA TGAAGTGCTC CTrCCAGGAC CTGGACCTCT GCCCTCTGGA TGGCGGCATC CAGCTACGAA TCTCCGACCA CCACTACAGC AAGGGCTTCA GGCAGGCCGC GTCAGTTGTT GTGGCCATGG ACAAGCTGAG GAAGATGCTG GTTCCCTGCC CACAGACC=F CCAGGAGAAT GACCTGAGCA CCTTCTTTCC CTTCATCTT GAAGAAGAAC CTATCT7T CGACACATGG GATAACGAGG CTTATGTGCA CGATGCACCT GTACGATCAC TGAACTGCAC WO 00/09525 PCT/US99/1 7712 ti-109 78 GCTCCGGGAC TCACAGCAAA AAAGCTrGcIT GATGTCTGGT CCATATGAAC TGAAAGCTCT CCACCTCCAG GGACAGGATA TGGAGCAACA AGTGGTGTrC TCCATGTCCT TTGTACAAGG AGAAGAAAGT AATGACAAAA TACCTGTGGC CTrGGGCCrC AAGGAAAAGA ATCTGTACCT GTCCTGCGTG TTGAAAGATG ATAAGCCCAC TCTACAGCTG GAGAGTGTAG ATCCCAAAAA TTACCCAAAG AAGAAGATGG AAAAGCGATr TGTCTCAAC AAGATAGAAA TCAATAACAA GCTGGAA'IM GAGTCTGCCC AGTrCCCCAA CTGGTACATC AGCAC(7TCTC AAGCAGAAAA CATGCCCGTC T7CCTGGGAG GGACCAAAGG CGGCCAGGAT ATAACTGACT TCACCATGCA A TrGTGTCT TCCTAAAGAG AGCTGTACCC AGAGAGTCCT GTGCTGAATG TGGACrCAAT CCCTAGGGCT GGCAGAAAGG GAACAGAAAG GTITGAGT ACGGCTATAG CCTGGAC'= CCTGTrGTCT ACACCAATGC CCAACTGCCT GCCTAGGGT AGTGCTAAGA GGATCTCCTG TCCATCAGCC AGGACAGTCA GCTCTCTCCT TI'CAGGGCCA ATCCCCAGCC CITITG7A GCCAGGCCTC TCTCACCTCT CCTACTCACT TAAAGCCCGC CTGACAGAAA CCACGGCCAC ATfTGGT'rCT AAGAAACCCT CTGTCATTCG CTCCCACATr CTGATGAGCA ACCGC'TrCCC TAIMA'TrA rrr7A'IGTr TGTTGTI= ATTCATrGGT CTAAM~AT7 CAAAGGGGGC AAGAAGTAGC AGTGTCTGTA AAAGAGCCTA GTITAATA GCTATGGAAT CAATrCAA'T TGGACTGGTG TGCTCTC'= AAATCAAGTC C'=AATTAA GACTGAAAAT ATATAAGCTC AGATTATTrA AATGGGAATA TI7ATAAATG AGCAAATATC ATACTGTrCA ATGGTrCTGA AATAAACTTC TCTGAAG AGAAAGAAAG AGAGAGAGAA AGAAAAGAAA GAGGAAGGAA GGAAGGAAGG AAGAAAGACA GGCTCTGAGG AAGGTGGCAG T7CCTACAAC GGGAGAACCA GTGGTrAATT TGCAAAGTGG ATCCTGTGGA GGCANNCAGA GGAGTCCCCT AGGCCACCCA GACAGGGC T7 AGCTATCT GCAGGCCAGA CACCAAATT17 CAGGAGGGCT CAGTGTrAGG AATGGATTAT GGCTrATCAA A'rrCACAGGA AACTAACATG T[GAACAGCT 1TrAGATITC CTGTGGAAAA TATAACTrAC TAAAGATGGA GTI7CTI7GTGA CTGACTCCTG ATATCAAGAT ACTGGGAGCC AAATTAAAAA TCAGAAGGCT GCTrGGAGAG CAAGTCCATG AAATGCTCT1 TCCCACAG TAGAACCTAT TlCCCTCGTG TCTCAAATAC flGCACAGAG GCTCACTCCC TrGGATAATG CAGAGCGAGC ACGATACCTG GCACATACTA ATT17GAATAA AATGCTGTCA AATrCCCATT CACCCAT7CA AGCAGCAAAC TCTATCTCAC CTGAATGTAC ATGCCAGGCA CTGTGCTAGA CTTGGCTCAA AAAGATrCA G'ITCCTGGA GGAACCAGGA GGGCAAGG~r TCAACTCAGT GCTATAAGAA GTGUrACAGG CTGGACACGG TGGCTCACGC CTGTAATCCC AACAM~GGG AGGCCGAGGC GGGCAGATCA CAAGGTCAGG AGATCGAGAC CATCCTGGCT AACATGGTGA AACCCTGTCT CTACTAAAAA TACAAAAAAT TAGCCGGGCG 77GGCGGCAG GTGCCTGTAG TCCCAGCTGC TGGGGAGGCT GAGGCAGGAG AATGGTGTGA ACCCGGGAGG CGGAACTGC AGGGGGCCGA GATCGTGCCA CTGCACTCCA GCCTGGGCGA CAGAGTGAGA CTCTGTCTCA AAAAAAAAAA AAAAGTGTTA TGATGCAGAC CTGTCAAAGA GGCAAAGGAG GGTG'I1CcTA CACTCCAGGC ACTGTrTCATA ACCTGGACTC TCA'ITCATC TACAAATGGA GGGCTCCCCT GGGCAGATCC CTGGAGCAGG CACT1GCTG GTGTCTCGGT TAAAGAGAAA CTGATAACTC FrGGTA~rAC CAAGAGATAG AGTCTCAGAT GGATATTCTT ACAGAAACAA TATTCCCACT rT7CAGAG'Fr CACCAAAAAA TCATMTAGG CAGAGCTCAT CTGGCATTGA TCTGGT7CAT CCATGAGAIT GGCTAGGGTA ACAGCACCTG GTCTTGCAGG GTTGTGTGAG =TATCTCCA GGGTrGCCCC AACTCCGTCA GGAGCCTGAA CCCTGCATAC CGTATGT7CT CTGCCCCAGC CAAGAAAGGT CAA=mCTC CTCAGAGGCT CCTGCAAT7G ACAGAGAGCT CCCGAGGCAG AGAACAGCAC CCAAGGTAGA GACCCACACC CTCAATACAG ACAGGGAGGG CTATTGGCCC FrCATTGTAC CCA'I7rATCC ATCTGTAAGT GGGAAGATTC CTAAACITAA GTACAAAGAA GTGAATGAAG AAAAGTATGT GCATGTATAA ATCTGTGTGT CT'rCCAC1T GTCCCACATA TACTAAATI AAACATTCT7 CTAACGTGGG AAAATCCAGT A'I1TTAATGT GGACATCAAC TGCACAACGA TrGTCAGGAA AACAATGCAT ATTGCATGG TGATACATT GCAAAATGTG TCATAGTIT7G CTACTC=~G CCCT'rCCATG AACCAGAGAA FrATCTCAGT TTATTAGTCC CCTCCCGTAA GAAGCT7CCA CCAATACTCT 'rrCCCcr C=ITAA=~ GATTGTGAAA TCAGGTATTC AACAGAGAAA TTFCrCAGCC TCCTACTCT GC1TrTGAAA GCTATAAAAA CAGCGAGGGA GAAACTGGCA GATACCAAAC CTCTCGAGG CACAAGGCAC AACAGGCTGC TCTGGGATrC TCT7CAGCCA ATM~CAFFG CTCAAGTATG ACI=AATCT TCCTTACAAC TAGGTGCTAA GGGAGTCTCT CTGTCTCTCT GCCTC'=GT GTGTATGCAT ATrCTCrCTC TCTCTCTCTT TCTICTCTG TCTCTCCTCT CCTTCCTCTC TGCCTCCTCT CTCAGCIT= TGCAAAAATG CCAGGTGTAA TATAATGCTr ATGACTCGGG AAATATrCTG GGAATGGATA CTGCTTATCT AACAGCTGAC ACCCTAAAGG T-rAGTGTCAA AGCCTCTGCT CCAGCTCTCC TAGCCAATAC A FrGCTAGT7 GGGGTI17GGT 'FfAGCAAATG C=ITCTCTA GACCCAAAGG A=~CT=T~ CACACATTCA TTCA'ITACT CAGAGATCAT rrTrGCAT GACTGCCATG CACTGGATGC TGAGAGAAAT CACACATGAA CGTAGCCGTC ATGGGGAAGT CACTCATIT CTCC1T!TA CACAGGTGTC TGAAGCAGCC ATGGCAGAAG TACCTGAGCT CGCCAGTGAA ATGATGGC'I7 AT7ACAGGTC AGTGGAGACG CTGAGACCAG TAACATGAGC AGGTCTCCTC =TCAAGAGT AGAGTGTTAT CTGTGCTGG AGACCAGATT TI'CCCCTAA ATTGCCTCT7 TCAGTGGCAA ACAGGGTGCC AAGTAAATCT GA'IMAAAGA CTA=WCCC ATTACAAGTC CCTCCAGCCT TGGGACCTGG AGGVITATCCA GATGTG'ITGT TGCAAGGGCT TCCTGCAGAG GCAAATGGGG AGAAAAGATT CCAAGCCCAC AATACAAGGA ATCCC1TGC AAAGTGTGGC TTGGAGGGAG AGGGAGAGCTr CAGAT1TAG CTGACTCTGC TGGGCTAGAG GTTAGGCCTC AAGATCCAAC AGGGAGCACC AGGGTGCCCA CCTGCCAGGC CTAGAATCTG CCT~rCTGGAC TG FrCTGCGC ATATCACTGT GAAA=FGCC AGGTGT1TrCA GGCAGC1TG AGAGGCAGGC TGTITGCAGT T1C=ATGAA CAGTCAAGTC FTGTACACAG GGAAGGAAAA ATAAACCTGT 17AGAAGACA TAATTGAGAC ATGTCCCTGT T1TAl7ACA GTGGCAATGA GGATGACTITG rITJTGAAG CTGATGGCCC TAAACAGATG AAGGTAAGAC TATGGG'T7A ACTCCCAACC CAAGGAAGGG CTCTAACACA GGGAAAGCTC AAAGAAGGGA G'ITCTGGGCC ACTTGATGC CATGGTAT17 TG=TAGAA AGACT=AAC CTCTrCCAGT GAGACACAGG CTGCACCACT TGCTGACCTG GCCACTTGGT CATCATATCA CCACAGTCAC TCACTAACGT TGGTGGTGGT GGCCACACTr GGTGGTGACA GGGGAGGAGT AGTGATAATG TTCCCATIC ATAGTAGGAA GACAACCAAG TCTTCAACAT AAA'TGATr ATCCT'TAA GAGATGGATT CAGCCTATGC CAATCACTTFG AGTTAAACTC TGAAACCAAG AGATGATcTr GAGAACTAAC ATATGTCTAC CCC71TGAG TAGAATAG~Fr I=GCTACC TGGGGTGAAG C=ATAACAA CAAGACATAG ATGATATAAA CAAAAAGATG AATrGAGACT TGAAAGAAAA CCA'ITCAM~ GCTGTT7GAC CfGACAAGT CATFIACCC GCITGGACC TCATCTGAAA AATAAAGGGC TGAGCTGGAT GATCTCTGAG ATrCCAGCAT CCTGCAACCT CCAGTrCTGA AATATFICA GTTGTAGCTA AGGGCAMFG GGCAGCAAAT GGTCAT=I CAGACTCATC CFACAAAGA GCCATGTTAT AT7CCTGCTG TCCCrGT TTATATGAT GCTCAGTAGC C~rCCTAGGT GCCCAGCCAT CAGCCTAGCT AGGTCAGT7G TGCAGGT7GG AGGCAGCCAC 7T=CTCTGG =-~ATI=A 'rrCCAGT-frG TGATAGCCTC CCCTAGCCTC ATAATCCAGT CCTCAATCTT GTTAAAAACA TATT=1TA GAAG=hrAA GACTGGCATA ACTrCTrGGC TGCAGCTGTG GGAGGAGCCC AT7GGMTGT CTGCCTGGCC TPGCCCCCC ATTGCCTCTT CCAGCAG=T GGCTCTGCTC CAGGCAGGAA AT~cTcrCCT GCTCAACTF C1TIGTGCA CTACAGGTC TC'TAACTG TCTICAAGC CTTGAACCA 17ATCAGCCT TAAGGCAACC TCAGTGAAGC C7rAATACGG AG=TCTCTG AATAAGAGGA AAGTGGTAAC AT 1TCACAAA AAGTACTCTC ACAGGKT~G CAGAATGCCT ATGAGACAGT G77ATGAAAA AGGAAAAAAA AGAACAG1TGT AGAAAAKFFG AATACF7GCT GAGTGAGCAT AGGTGAATGG AAAATGTrAT GGTCATCTGC ATGAAAAAGC AAATCATAGT GTGACAGCAT TAGGGATACA AAAAGATATA WO 00/09525 PCT/US99/17712 tri-OY 79 GAGAAGGTAT ACATGTATGG TGTAGGTGGG GCATGTACAA AAAGATGACA AGTAGAATCG GGA'F~rA'rrC TAAAGAATAG CCTGTAAGGT GTCCAGAAGC CACA~rCTAG TCI-rGAGTCT GCCTCTACCT GCTGTGTGCC CT7GAGTACA CCCYIAACCT CCTTGAGCTF CAGAGAGGGA TAATCTTTT ATITATI A=A=NT~ G~m'TGrIT G=T'G=II GTIATGAG ACAGAGTCTC ACTCTGTrGC CCAGGCTGGA GTGCAGTGGT ACAATCT7GG CTTACTGCAT CCTCCACCTC CTGAGTrCAA GCGA'FrCTCC TCC7CAGTC TCCTGAATAG CTAGGATrAC AGGTGCACCC CACCACACCC AGCTAA=I1 TGTArTrA GTAGAGAAG3G GGTITCGCCA TGTTGGCCAG GCTGGT1TG AAGTCCTGAC CTAAATGATT CATCCACCTC GGCT7CCCAA AGTGCTGGGA T7ACAGGCAT GAGCCACCAC GCCTGGCCCA GAGAGGGATG ATC'TAGAA GCTCGGGA'IT C1TCAAGCC =T~CCrCCT CTCTGAGCTF7 TCTACTCTCT GATGTCAAAG CATGGTI'CCT GGCAGGACCA CCTCACCAGG CTCCCTCCCT CGCTCTCTCC GCAGTGCTCC T7CCAGGACC TGGACCTCTG CCCTCTGGAT GGCGGCATCC AGCTACGAAT CTCCGACCAC CACTACAGCA AGGGCTTCAG GCAGGCCGCG TCAGT-fGITG TGGCCATGGA CAAGCTGAGG AAGATGCTGG TrCCCTGCCC ACAGACCT'rC CAGGAGAATG ACCTGAGCAC CrmCCC TTCATCTFG AAGAAGGTAG TTAGCCAAGA GCAGGCAGTA GATCTCCACT TGTGTCCTCT TGGAAGTCAT CAAGCCCCAG CCAACTCAAT TCCCCCAGAG CCAAAGCCCT TTAAAGGTAG AAGGCCCAGC GGGGAGACAA AACAAAGAAG GCTGGAAACC AAAGCAATCA TCT=T~AGT GGAAACrATT CTTAAAGAAG ATCTGATGG CTACTGACAT TFrGCAACTCC CTCACTCT= CTCAG1GGGCC 'ITTCACTTAC A'ITGTCACCA GAGGTTCGTA ACCTCCCTGT GGGCTAGTGT TATGACCATC ACCA=I]AC CTAAGTAGCT CTGTTGCTCG GCCACAGTGA GCAGTAATAG ACCTGAAGCT GGAACCCATG TCTAATAGTG TCAGGTCCAG TG'FrCTrAGC CACCCCACTC CCAGCT7CAT CCCTACTGGT G17GTCATCA GACITGACC G3TATATGCTC AGGTGTCCTC CAAGAAATCA AATITGCCA CCTCGCCTCA CGAGGCCTGC CCTrCTGATT TTATACCTAA ACAACATGTG CTCCACA'TrT CAGAACCTAT CTTCTrCGAC ACATGGGATA ACGAGGCTTA TGTGCACGAT GCACCTGTAC GATCACTGAA CTGCACGCTC CGGGACTCAC AGCAAAAAAG CTGGTGATG TCTGGTCCAT ATGAACTGAA AGCTCTCCAC CTCCAGGGAC AGGATATGGA GCAACAAGGT AAATGGAAAC ATCCTGGTI CCCTGCCTGG CCTCCTGGCA G=TGCTAAT TCTCCATG'T TI'AAACAAAG TAGAAAGTTA AMrAAGGCA AATGATCAAC ACAAGTGAAA AAAAATAUTA AAAAGGAATA TACAAA=rr GGTCCTAGAA ATGGCACATr TGATTGCACT GGCCAGTGCA TITGTTAACA GGAGTGTGAC CCTGAGAAAT TAGACGGCTC AAGCACTCCC AGGACCATGT CCACCCAAGT CTCTGGGCA TAGTGCAGTG TCAATrC'FrC CACAATATGG GGTCATI'GA TGGACATGGC CTAACTGCCT GTGGGrCTC TC'FCCTG'rr GT-rGAGGCTG AAACAAGAGT GCTGGAGCGA TAATGTGTCC ATCCCCCTCC CCAGTCTrCC CCCCTrGCCC CAACATCCGT CCCACCCAAT GCCAGGTGGT TCCTITGTAGG GAAATITAC CGCCCAGCAG GAACTTATAT CTCTCCGCTG TAACGGGCAA AAG'TTrCAAG TGCGGTGAAC CCATCATrAG CTGTGGTGAT CTGCCTGGCA TCGTGCCACA GTAGCCAAAG CCTCTGCACA GGAGTGTGGG CAACTAAGGC TGCTGAC1T GAAGGACAGC CTCACTCAGG GGGAAGCTAT TTGCTCTCAG CCAGGCCAAG AAAATCCTGT TrC=rGGAA TCGGGTAGTA AGAGTGATCC CAGGGCCTCC AATrGACACT GCTGTGACTG AGGAAGATCA AAATGAGTGT CTCT='~GG AGCCAcI=C CCAGCTCAGC CTCTCCTCTC CCAGTI17CTT CCCATGGGCT ACTCrCTGTT CCTGAAACAG TrCTGGTGCC TGAT1T7CrGG CAGAAGTACA GCT7CACCTC rrrC=rCC TTCCACATTG ATCAAGTITGT TCCGCTCCTG TGGATGGGCA CATrGCCAGC CAGTGACACA ATGGCTTCCT TCCTrCCT7rC CrrCAGCATr TAAAATGTAG ACCCTCC ATTCrCCG3Tr CCTACTGCTA TGAGGCTCTG AGAAACCCTC AGGCCI I IGA GGGGAAACCC TAAATCAACA AAATGACCCT GCTA ITGTCT GTGAGAAGTC AAGT7ATCCT GTGTCTI'AGG CCAAGGAACC TCACTGTGGG TITCCCACAGA GGCTACCAAT TACATGTATC CTACTCTCGG GGCTAGGGGT TGGGGTGACC CTGCATGCTG TGTCCCTAAC CACAAGACCC CCTTITCT TCAGTGGTGT TCTCCATGTC C=rGTACAA GGAGAAGAAA GTAATGACAA AATACCTGTG GCCTrGGGCC TCAAGGAAAA GAATCTGTAC CTGTCCTGCG TGTTGAAAGA TGATAAGCCC ACTCTACAGC TGGAGGTAAG TGAATGCTAT GGAATGAAGC CCTTCTCAGC CTCCTGCTAC CACTA7rCC CAGACAATrC AC=CrCCC CGCCCCCATC CCrAGGAAAA GCTGGGAACA GGTCTATTG ACAAG=1FG CATTAATGTA AATAAATITA ACATAA=II TAACTGCGTG CAACCITCAA TCCTGCTGCA GAAAATTAAA TCAFIIGCC GATG'ITATTA TGTCCTACCA TAGITACAAC CCCAACAGAT TATATATrGT TAGGGCTGCT CTCA'TrGAT AGACACCTTG GGAAATAGAT GACTTAAAGG GTCCCAT7AT CACGTCCACT CCACTCCCAA AATCACCACC ACTATCACCT CCAGC=rCT CAGCAAAAGC TI7CATTI7CCA AGTTGATGTC ATTCTAGGAC CATAAGGAAA AATACAATAA AAAGCCCCTG GAAACTAGGT A=rCAAGAA GCTCTAGC'Fr AAYITCACC CCCCCAAAAA AAAAAAATTIC TCACCTACAT TATGCTCCTC AGCATT7GGC ACTAAG=fl AGAAAAGAAG AAGGGCTCTr TTAATAATCA CACAGAAAGT TGGGGGCCCA GT7ACAACTC AGGAGTCTGG CTCCTGATCA TGTGACCTGC TCGTCAG'Tf CCTF7CTGGC CAACCCAAAG AACAT=1JC CCATAGGCAT C1TGTCCCT TGCCCCACAA AAATIr=CT 'FrCT=rrCG CTGCAGAGTG TAGATCCCAA AAATTACCCA AAGAAGAAGA TGGAAAAGCG AT'1rGTCTTC AACAAGATAG AAATCAATAA CAAGCTGGAA TTGAGTCTG CCCAGTrCCC CAACTGGTAC ATCAGCACCT CTCAAGCAGA AAACATGCCC GTCfl'CCTGG GAGGGACCAA AGGCGGCCAG GATATAACTG ACTMCACCAT GCAATTITGTG TCTCCTAAA GAGAGCTGTA CCCAGAGAGT CCTGTGCTGA ATGTGGACTC AATCCCTAGG GCTGGCAGAA AGGGAACAGA AAGGTFI1G AGTACGGCTA TAGCCTGGAC MICCTGTrG TCTACACCAA TGCCCAACTG CCTGCCT7AG GGTAGTGCTA AGAGGATCTC CTGTCCATCA GCCAGGACAG TCAGCTCTCT CC=rCAGGG CCAATCCCCA GCCCTITGT TGAGCCAGGC CTCTCTCACC TCTCCTACTC AC=AAAGCC CGCCTGACAG AAACCACGGC CACATI17GGT TCTAAGAAAC CCTCTGTCAT TCGCTCCCAC A TCTGATGA GCAACCGCT CCCTATT7AT TTATI7ATI7 GMI1GT11GT 'T7GATTCAT TGGTCTAATr TATTCAAAGG GGGCAAGAAG TAGCAGTGTC TGTAAAAGAG CCTAGTTr AATAGCTATG GAATCAATTC AA'I=GGACT GGTGTGCTCT CTTAAATCA AGTCCITAA TITAAGACTGA AAATATATAA GCTCAGATI'A ITT7AAATGGG AATATTATA AATGAGCAAA TATCATACTG TTCAATGGTr CTGAAATAAA CTTCACTrGAA GAAAAAAAAA AAAGGGTCTC TCCTGATCAT TGACTGTCTG GAFrGACACT GACAGTAAGC AAACAGGCTG TGAGAGTTCT TGGGACTAAG CCCACTCCTC AT7GCTGAGT GCTGCAAGTA CCTAGAAATA TCCIGGCCA CCGAAGACTA TCCTCCTCAC CCATCCCCT TKTCGTTG TTCAACAGAA GGATATTCAG TGCACATCTG GAACAGGATC AGCTGAAGCA CTGCAGGGAG TCAGGACTGG TAGTAACAGC TACCATGATI7 TATCTATCAA TGCACCAAAC ATCTGTTGAG CAAGCGCTAT GTACTAGGAG CTGGGAGTAC AGAGATGAGA ACAGTCACAA GTCCCTCCTC AGATAGGAGA GGCAGCTAGT TATAAGCAGA ACAAGGTAAC ATGACAAGTA GAGTAAGATA GAAGAACGAA GAGGAGTAGC CAGGAAGGAG GGAGGAGAAC GACATAAGAA TCAAGCCTAA AGGGATAAAC AGAAGA'IMC CACACATGGG CTGGGCCAAT TGGGTGTCGG TrACGCCTGT AATCCCAGCA CT=GGGTGG CAGGGGCAGA AAGATCGCTT GAGCCCAGGA GTrCAAGACC AGCCTGGGCA ACATAGTGAG ACTCCCATCT CTACAAAAAA TAAATAAATA AATAAAACAA TCAGCCAGGC ATGCTGGCAT GCACCTGTAG TCCTAGCTAC T7GGGAAGCT GACACTGGAG GAT7GCT'TGA GCCCAGAAGT TCAAGACTGC AGTGAGCTTA TCCG FrGACC TGCAGGTCGA C ACAAAC=rF TCGAGGCAAA AGGCAAAAAA GGCTGCTCTG GGA77CT=~ CAGCCAATCT TCAATGCTCA AGTGTCTGAA GCAGCCATGG CAGAAGTACC TAAGCTCGCC AGTGAAATGA TGGCTTATTA CAGTGGCAAT GAGGATGACT TG 'Tr=GA AGCTGATGGC CCTAAACAGA TGAAGTGCTC C=1CCAGGAC CTGGACCTCT GCCCTCTGGA TGGCGGCATC CAGCTACGAA TCTCCGACCA WO 00/09525 PCT/US99/17712 EPI-109 80 CCACTACAGC AAGGGCTTCA GGCAGGCCGC GTCAGTTGTT GTGGCCATGG ACAAGCTGAG GAAGATGCTG GTTCCCTGCC CACAGACCTr CCAGGAGAAT GACCTGAGCA CCTrCTTTCC CTTCATCTTT GAAGAAGAAC CTATCTTCTT CGACACATGG GATAACGAGG CTTATGTGCA CGATGCACCT GTACGATCAC TGAACTGCAC GCTCCGGGAC TCACAGCAAA AAAGCTTGGT GATGTCTGGT CCATATGAAC TGAAAGCTCT CCACCTCCAG GGACAGGATA TGGAGCAACA AGTGGTGTTC TCCATGTCCT TTGTACAAGG AGAAGAAAGT AATGACAAAA TACCTGTGGC CTTGGGCCTC AAGGAAAAGA ATCTGTACCT GTCCTGCGTG TTGAAAGATG ATAAGCCCAC TCTACAGCTG GAGAGTGTAG ATCCCAAAAA TTACCCAAAG AAGAAGATGG AAAAGCGATT TGTCTTCAAC AAGATAGAAA TCAATAACAA GCTGGAATTT GAGTCTGCCC AGTTCCCCAA CTGGTACATC AGCACCTCTC AAGCAGAAAA CATGCCCGTC TTCCTGGGAG GGACCAAAGG CGGCCAGGAT ATAACTGACT TCACCATGCA ATTTGTGTCT TCCTAAAGAG AGCTGTACCC AGAGAGTCCT GTGCTGAATG TGGACTCAAT CCCTAGGGCT GGCAGAAAGG GAACAGAAAG GTITr GAGT ACGGCTATAG CCTGGACTTT CCTGTTGTCT ACACCAATGC CCAACTGCCT GCCTTAGGGT AGTGCTAAGA GGATCTCCTG TCCATCAGCC AGGACAGTCA GCTCTCTCCT TTCAGGGCCA ATCCCAGCCC TTTTGTrGAG CCAGGCCTCT CTCACCTCTC CTACTCACTT AAAGCCCGCC TGACAGAAAC CAGGCCACAT TTTGGTTCTA AGAAACCCTC CTCTGTCATT CGCTCCCACA TrCTGATGAG CAACCGCTTC CCTATTTATT TATTTATTTG TTTGTTTGT7 T TGATTCATT GGTCTAATTr ATTCAAAGGG GGCAAGAAGT AGCAGTGTCT GTAAAAGAGC CTAGTTTTTA ATAGCTATGG AATCAATTCA ATTTGGACTG GTGTGCTCTC TTTAAATCAA GTCCTTTAAT TAAGACTGAA AATATATAAG CTCAGATTAT TTAAATGGGA ATATTTATAA ATGAGCAAAT ATCATACTGT TCAATGGTTC TCAAATAAAC TTCACT CTGGCAGGAG TAGCAGCTGC CCCTTGGCGC GACTGCTGGA GCCGCGAACT AGAGAAACAC AGACACGCCT CATAGAGCAA CGGCGTCTCT CGGAGCGTGG AGCCCGCCAA GCTCGAGCTG AGCTTTCGCT TGCCGTCCAC CACTGCCCAC ACTGTCGTTT GCTGCCATCG CAGACCTGCT GCTGACTTCC ATCCCTCTGG ATCCGGCAAG GGCCTGCGAT TTTGACAATG TCAAGATTTA CCGTATATCC CTGTTTGTTT GGATACACCA GTGACGTCCA CTTCTAGAAG ACAAAGTTAT ATTACTTAAA CAACCAAAGA TATGAAACTA TCCATGAAGA ACAATATTAT CAATACACAG CAGTCTITIG TAACCATGCC CAATGTGATT GTACCAGATA TTGAAAAGGA AATACGAAGG ATGGAAAATG GAGCATGCAG CTCCTTITTCT GAGGATGATG ACAGTGCCTC TACATCTGAA GAATCAGAGA ATGAAAACCC TCATGCAAGG GGTTCCTTTA GTTATAAGTC ACTCAGAAAG GGAGGACCAT CACAGAGGGA GCAGTACCTG CCTGGTGCCA TTGCCATTTT TAATGTGAAC AACAGCGACA ATAAGGACCA GGAACCAGAA GAAAAAAAGA AAAAGAAAAA AGAAAAGAAG AGCAAGTCAG ATGATAAAAA CGAAAATAAA AACGACCCAA AGAAGAAGAT GGAAAAGCGA ATGGCCAAAG TTCCAGACAT GTTrGAAGAC CTGAAGAACT GTTACAGTGA AAATGAAGAA GACAGTTCCT CCATTGATCA TCTGTCTCTG AATCAGAAAT CCTTCTATCA TGTAAGCTAT GGCCCACTCC ATGAAGGCTG CATGGATCAA TCTGTGTCTC TGAGTATCTC TGAAACCTCT AAAACATCCA AGCTTACCTT CAAGGAGAGC ATGGTGGTAG TAGCAACCAA CGGGAAGGTT CTGAAGAAGA GACGGTTGAG TTTAAGCCAA TCCATCACTG ATGATGACCT GGAGGCCATC GCCAATGACT CAGAGGAAGA AATCATCAAG CCTAGGTCAG CACCTTTTAG CTTCCTGAGC AATGTGAAAT ACAACTTTAT GAGGATCATC AAATACGAAT TCATCCTGAA TGACGCCCTC AATCAAAGTA TAATTCGAGC CAATGATCAG TACCTCACGG CTGCTGCATT ACATAATCTG GATGAAGCAG TGAAATTTGA CATGGGTGCT TATAAGTCAT CAAAGGATGA TGCTAAAATT ACCGTGATTC TAAGAATCTC AAAAACTCAA TTGTATGTGA CTGCCCAAGA TGAAGACCAA CCAGTGCTGC TGAAGGAGAT GCCTGAGATA CCCAAAACCA TCACAGGTAG TGAGACCAAC CTCCTCTTCT TCTGGGAAAC TCACGGCACT AAGAACTATT TCACATCAGT TGCCCATCCA AACTTGTTTA TTGCCACAAA GCAAGACTAC TGGGTGTGCT TGGCAGGGGG GCCACCCTCT ATCACTGACT TTCAGATACT GGAAAACCAG GCGTAGGTCT GGAGTCTCAC TTGTCTCACT TGTGCAGTGT TGACAGTTCA TATGTACCAT GTACATGAAG AAGCTAAATC CTTTACTGTT AGTCATTTGC TGAGCATGTA CTGAGCCTTG TAATTCTAAA TGAATGTTTA CACTCTTTGT AAGAGTGGAA CCAACACTAA CATATAATGT TGTTATTTAA AGAACACCCT ATATTTTGCA TAGTACCAAT CATTTTAATT ATTATTCTTC ATAACAATTT TAGGAGGACC AGAGCTACTG ACTATGGCTA CCAAAAAGAC TCTACCCATA TTACAGATGG GCAAATTAAG GCATAAGAAA ACTAAGAAAT ATGCACAATA GCAGTTGAAA CAAGAAGCCA CAGACCTAGG ATTTCATGAT TTCATTTCAA CTGTITGCCT TCTGCTTTTA AGTTGCTGAT GAACTCTTAA TCAAATAGCA TAAGTTTCTG GGACCTCAGT TTTATCATTT TCAAAATGGA GGGAATAATA CCTAAGCCTT CCTGCCGCAA CAGTTTTTTA TGCTAATCAG GGAGGTCATT TTGGTAAAAT ACTTCTCGAA GCCGAGCCTC AAGATGAAGG CAAAGCACGA AATGTTATTT TTTAATTATT ATTTATATAT GTATTTATAA ATATATTTAA GATAATTATA ATATACTATA TTTATGGGAA CCCCTTCATC CTCTGAGTGT GACCAGGCAT CCTCCACAAT AGCAGACAGT GTTTTCTGGG ATAAGTAAGT TTGA'TrCAT TAATACAGGG CATTTTGGTC CAAGTTGTGC TTATCCCATA GCCAGGAAAC TCTGCATTCT AGTACTTGGG AGACCTGTAA TCATATAATA AATGTACATT AATTACCTTG AGCCAGTAAT TGGTCCGATC TTTGACTCTT TTGCCATTAA ACTTACCTGG GCATTCTTGT TTCATTCAAT TCCACCTGCA ATCAAGTCCT ACAAGCTAAA ATTAGATGAA CTCAACTTTG ACAACCATAG ACCACTGTTA TCAAAACFTT CTITrCTGGA ATGTAATCAA TGTTTCTTCT AGGTTCTAAA AATTGTGATC AGACCATAAT GTTACATTAT TATCAACAAT AGTGATTGAT AGAGTGTTAT CAGTCATAAC TAAATAAAGC TTGCAAGTGA GGGAGTCATT TCATTGGCGT TTGAGTCAGC AAAGAAGTCA AG AGCTGCCAGC CAGAGAGGGA GTCA'TTCAT TGGCGTr'GA GTCAGCAAAG AAGTCAAGAT GGCCAAAGTT CCAGACATGT TTGAAGACCT GAAGAACTGT TACAGTGAAA ATGAAGAAGA CAGTTCCTCC ATTGATCATC TGTCTCTGAA TCAGAAATCC TTCTATCATG TAAGCTATGG CCCACTCCAT GAAGGCTGCA TGGATCAATC TGTGTCTCTG AGTATCTCTG AAACCTCTAA AACATCCAAG CTTACCTTCA AGGAGAGCAT GGTGGTAGTA GCAACCAACG GGAAGGTTCT GAAGAAGAGA CGGTTGAGTT TAAGCCAATC CATCACTGAT GATGACCTGG AGGCCATCGC CAATGACTCA GAGGAAGAAA TCATCAAGCC TAGGTCATCA CCTTTTAGCT TCCTGAGCAA TGTGAAATAC AACTTTATGA GGATCATCAA ATACGAATTC ATCCTGAATG ACGCCCTCAA TCAAAGTATA ATTCGAGCCA ATGATCAGTA CCTCACGGCT GCTGCATTAC ATAATCTGGA TGAAGCAGTG AAATTTGACA TGGGTGCTTA TAAGTCATCA AAGGATGATG CTAAAATTAC CGTGATTCTA AGAATCTCAA AAACTCAATT GTATGTGACT GCCCAAGATG AAGACCAACC AGTGCTGCTG AAGGAGATGC CTGAGATACC CAAAACCATC ACAGGTAGTG AGACCAACCT CCTCTTCTTC TGGGAAACTC ACGGCACTAA GAACTATTTC ACATCAGTTG CCCATCCAAA CTTGTTTATT GCCACAAAGC AAGACTACTG GGTGTGCTTG GCAGGGGGGC CACCCTCTAT CACTGACTIT CAGATACTGG AAAACCAGGC GTAGGTCTGG AGTCTCACTT GTCTCACTTG TGCAGTGTTG ACAGTTCATA TGTACCATGT ACATGAAGAA GCTAAATCCT TTACTGTTAG TCATTTGCTG AGCATGTACT GAGCCTTGTA ATTCTAAATG AATGTTTACA CTCTTTGTAA GAGTGGAACC AACACTAACA TATAATGTTG TTATTTAAAG AACACCCTAT ATTTTGCATA GTACCAATCA TTTTAATTAT TATTCTTCAT AACAATTTTA GGAGGACCAG AGCTACTGAC TATGGCTACC AAAAAGACTC TACCCATATT ACAGATGGGC AAATTAAGGC ATAAGAAAAC TAAGAAATAT GCACAATAGC AGTCGAAACA AGAAGCCACA GACCTAGGAT TTCATGATFT CATTTCAACT GTTTGCCTTC TGCiTTTAAG TTGCTGATGA ACTCTTAATC AAATAGCATA AGTICTGGG ACCTCAGTTT TATCATTTTC AAAATGGAGG GAATAATACC TAAGCCTTCC TGCCGCAACA GT1T1TiATG CTAATCAGGG AGGTCATITT GGTAAAATAC TTCTCGAAGC CGAGCCTCAA GATGAAGGCA AAGCACGAAA TGTTATTTTT TAATTATTAT TTATATATGT ATTTATAAAT ATATrTAAGA WO 00/09525 PCT/US99/1 7712 EFI-109 81 TAATrATAAT ATACTATATT TATGGGAACC CC'TrCATCCT CTGAGTGTGA CCAGGCATCC TCCACAATAG CAGACAGTGT 'TCTGGGAT AAGTAAG IT7 GAMrCATrA ATACAGGGCA TI=GGTCCA AG'rrGTGCT7 ATCCCATAGC CAGGAAACTC TGCATI'CTAG TACTrGGGAG ACCTGTAATC ATATAATAAA TGTACATTAA TrACCTrGAG CCAGTAAF1G GTCCGATCIT TGACTCTIT GCCATTAAAC ITFACCTGGGC AT7CTrG'ITT CATTCAATTC CACCTGCAAT CAAGTCCTAC AAGCTAAAAT TAGATGAACT CAACI=GAC AACCATGAGA CCACTGflAT CAAAAC1TC TITCTGGAA TGTAATCAAT G'iTcT-rCrA GGTrCTAAAA ATTGTGATCA GACCATAATG T7ACATTATT ATCAACAATA GTGA'ITGATA GAGTGTTATC AGTCATAACT AAATAAAGCT TGCAACAAAA T7CTCTG GCTCAGGGCA CATGCCTCCC CTCCCCAGGC CGCGGCCCAG CTGACCCTCG GGGCTCCCCC GGCAGCGGAC AGGGAAGGGT TAAAGGCCCC CGGCTCCCTG CCCCCTGCCC TGGGGAACCC CTGGCCCTGT GGGGACATGA ACTGTGTT7G CCGCCTGGTC CTGGTCGTGC TGAGCCTGTG GCCAGATACA GCTGTCGCCC CTGGGCCACC ACCTGGCCCC CCTCGAGIT CCCCAGACCC TCGGGCCGAG CrGGACAGCA CCGTGCTCCT GACCCGCTCT CTCCTGGCGG ACACGCGGCA GCTGGCTGCA CAGCTGAGGG ACAAATTCCC AGCTGACGGG GACCACAACC TGGATTCCCT GCCCACCCTG GCCATGAGTG CGGGGGCACT GGGAGCTCTA CAGCTCCCAG GTGTGCTGAC AAGGCTGCGA GCGGACCTAC TGTCCTACCT GCGGCACGTG CAGTGGCTGC GCCGGGCAGG TGGCTCTTCC CTGAAGACCC TGGAGCCCGA GCTGGGCACC CTGCAGGCCC GACTGGACCG GCTGCTGCGC CGGCTGCAGC TCCTGATGTC CCGCCTGGCC CTGCCCCAGC CACCCCCGGA CCCGCCGGCG CCCCCGCTGG CGCCCCCCTC CTCAGCCTGG GGGGGCATCA GGGCCGCCCA CGCCATCCTG GGGGGGCTGC ACCTGACACT TGACTGGGCC GTGAGGGGAC TGCTGCTGCT GAAGACTCGG CTGTGACCCG GGGCCCAAAG CCACCACCGT CCT7CCAAAG CCAGATCTTA M~AT=A'IT TATrrTCAGTA CTGGGGGCGA AACAGCCAGG TGATCCCCCC GCCA17ATCT CCCCCTAGTT AGAGACAGTC =TCCGTGAG GCC7GGGGGA CATCTGTGCC TTA'ITATAC 'FrATrTA'T7 CAGGAGCAGG GGTGGGAGGC AGGTGGACTC CTGGGTCCCC GAGGAGGAGG GGACTGGGGT CCCGGATTCT TGGGTCTCCA AGAAGTCTGT CCACAGAC17 CTGCCCTGGC TCT7CCCCAT CrrAGGCCTGG GCAGGAACAT ATATrA'IA IMAAGCAAT TACT1TCAT GTTGGGGTGG GGACGGAGGG GAAAGGGAAG CCTGGGTIT TGTACAAAAA TGTGAGAAAC =TIGTGAGA CAGAGAACAG GGAATTAAAT GTGTCATACA TATCC CAGCTGCGGC ATCCTCTGTC TCAGAGTCT7 GGTGTCTCTG TrCcrCCC CTCGGGGTCT CCCTGGGTCT CCCCAAGTCC CTCCTGCTGT CrCCTCCCG CTCTCTGATC TCTGACTCCC AGAACCTCTC CCTCTGTCTC CAGGGCTGCC CCTCTGATCC TC'=GCrrC TCTGGTGTGT CTCTCTGGCT GCCTCCATCT CTGTGGATCT CCGTCTCCCT GTCTCTGTCT CAGTCTGTCC TCACTCTGT GTGTGTGTGT GTCTCTCTCT CTCTCTCTCC rFICCCTIrCCA CTCCCTCT7C CTCCTGCCTC CACCTCTCCA GGCCCCTGTC TrGTCCCTCC GTCCGGC=T TCTCTGCCT TCCGTCCTCC TGCCTCCCCA TCTCTCTCTG CTAGTCCTGT CCAGCCGGAC CCCCACCCAC AGTCGGGCCC CAGCGCTrGA GCCTGAGTGT CTGCTCCGGC CCGTGGAGGT GGAGGGAGGG GACGCCAATG ACCTCACCAG CCCCTCTCCG ACCACCCCCC CC'=CCCT r CAACTFI CCAACI=rC C1I'CCGTGCC CTCCTCCGAG CGCGGCGGCG TGAGCCCTGC AAGGCAGCCG CTCCGTCTGA ATGGAAAAGG CAGGCAGGGA GGGTGAGTCA GGATGTGTCA GGCCGGCCCT CCCCTGCCGC CTGCCCCCCG CCCGCCCGCC CCAGGCCCCC TATATAACCC CCCAGGCGTC CACACTCCCT CACTGCCGCG GGCCCTGCTG CTCAGGGCAC ATGCCTCCCC TCCCCAGCCG CGGGCCCAGC TGACCCTCGG GGCTCCCCCG GCAGCGGACA GGGAAGGGTT AAAGGCCCCC GGCTCCCTGC CCCCTGCCCT GGGGAACCCC TGGCCCTGTG GGGACATGAA CTGTAAGTTG GTTCATGGGG AGGGTGGAGG GGACAGGGAG GCAGGGAGGA GAGGGACCCA CGGCGGGGGT GGGAGCAGAC CCCGCTGAGT CGCACAGAGA GGGACCCGGA GACAGGCAGC CGGGGAGGAG AGCAGCTTCG GAGACAGGAG GCGGCGGAGG AGATGGGCAG AGAGAGACAC AGACAGGAGC GGATGGAGGC AGCCAATCAG AGGCGCCGCA GGAGGGACGG GCCAGACAGG GCCCGAGAGG AGCGAGACGC GAGACCGAGC AGGGGCAGGG ACGCAGGGAC TGGTGCCGGG AGGGAGGTGA CCCCCATCGA CCCAGGCCCC AGGGAGCCCG CGGGGACCGG GAGACTCCCT GGGATTCCGG CAGAGAGGCT CCGGAGGGAA ACTGAGGCAG GGTCCGCGGA GAGCGGAGCA AGCCAGGGAG TAGCGACCCC AGCCGGGGGG AGGAGAGAGA CTGGGCGCCG GGGGAAAGCG GGGAGAGCCG GGCAGATGCG GCCGACGGAG GCGCGGACAG ACCGACGGCT GGCGGGCCCG GGGGGCGGGC TGGGGGTGTG CGAGGCGCGG GCGGCCGGGG AGCGCTGA'Fr GGCTGGCGGG TGGCCGGGTG GGCGGGGCGG CCGGGGTGGG CTGCGGGGAG CGAGCTCCGG ACCCCCGCGC CCCCGGCGCC CCCCGCGCCC CCCGCCGCCA GCTCTCCCGC TCCCGGCGCC CGGCCGGGCC ATGGCTCTGC CCCTCTCCGC CCAGGTGCGC TGCGGCCCGG G=CTTGCCG CCCACCCGGC GGGCTCCTGG GAGGGCGTCT AAGGGGTCTC CCGTGGGAGA GGTCCGTGTC TCCCGGACTC CGTCVITGGGC =FTGGCTCC TTCCCCTGCT CCCAGCCAGC TCGGGCTCCC GCGGCCCGGG GAGGGGGCAG G~rCTGGCCT GTGCCTCCCC CACCATCCGC GCCCCGGGGC CCAGATTCCG GCGTCCGGGG GCGGACGGGA GACGCCCGGG CCGCGTCTGC TCCGACGGGC GGGGCAGCCA GAGCCAGGGA GGGAGAGGGA AGCCCGCCTG GCCCTGCGAC CTGCCCGCGG GCGTTCCACC CTGGGACTTA AGACCTCCAG CTCCATCCTC CCTAAGGCCG GGAGTCCAGG CCCCAGACCC TCCTCCCCGA GACCCAGGAG TCCAGACCCC AGGCCITCCT CCCTCAGACC TAGGAGTCCA GGCCCCCAGC CTCTCCTCCC TCAGACCCAG GAGGAGTCCA GACCCCAG17 CCTCCTCCCT CAGACCCGGG AGTCCAGCCC AGGCCCTCCTr CTCTCAGACC CGGAGTCCAG CCTGAGCTCT CTGCCTTATC CTGCCCCCAG GTGTfGCCG CCTGGTCCTG GTCGTGCTrGA GCCTGTGGCC AGATACAGCT GTCGCCCCTG GGCCACCACC TGGCCCCCcT CGAGTICCC CAGACCCTCG GGCCGAGCTG GACAGCACCG TGCTCCTGAC CCGCTCTCTC CTGGCGGACA CGCGGCAGCT GGCTGCACAG CrGGTAGGAG AGACTGGGCT GGGGCCAGCA CAGGAGTGAG AGGCAGAGAG GAACGGAGAG GAGTCTGCGG GCAGCCACTT GGAGGGGTTC TGGGCTCTCA GGTGGCAGAG TGAGGGAGGG GAAGAGTTGG GGGCCTGGCG TGGGGGATGG AGGGAGCCCC GAGGCTGGGC AGGGGCCACC TCACAGcTI TTCCCTGCC AGAGGGACAA ATTCCCAGCT GACGGGGACC ACAACCTGGA TTCCCTGCCC ACCCTGGCCA TGAGTGCAGG GGCACTGGGA GCTCTACAGG TAAGGGCAAG GGAGTGGGCT GGGGACAAGG TGGGAGGCAG GCAGTGAAGG GGGCGGGGAG GATGAGGGGC ACTGGTCGGG TGrrCTCTGA TGTCCCGGCTr CTATCCCCAG CTCCCAGGTG TGCTGACAAG GCTGCGAGCG GACCrACTGT CCTACCTGCG GCACGTGCAG TGGCTGCGCC GGGCAGGTGG CTCTTCCCTG AAGACCCTGG AGCCCGAGCT GGGCACCCTG CAGGCCCGAC TGGACCGGCT GCTGCGCCGG CTGCAGCTCC TGGTATGTCC TGGCCCCAAG ACCTGACACC CCAGACCCCC ACCCCTGGCC CCAAAATCCT GTGGCCTGAG TCCTGAAGC CTGAGACCCC AGACCCGAGT GCAACAGCCC CGCTCTGAGA CCCTGACACC CTAACAGCCC GCTCTGAGAC CCTGACACCG TAACAGCCCC GCTCTGAGAC CCTGACCCTA ACAGTCCTGC TCTGAGACCC TGACCCTGCA GTCCCAAGAT CCTGTGGCCC TGAGACCCTG AGGCCCTAGA CCCCCAAATC CTGCCCAGAA ACTrCAAA~r CTCACCCAAG ACCCTFGAGAC TCCATCATCC ATGACCTCAA AGTCCCCAGA TCCCAGCCCC TAAGACCCAA GACCCCATCC TGAAGCCCAA AGCCTTGAGA ATTCAAATCC TCACCTCAAG ACITGGAGAC CCTGGCCCCA TGACAITrGAA AACCATGGAC CTGGCCAGGC GTGGTGGCTC ACGCCTGTAA TCCCAGCACT T7GGGAGGCC GAGGCAAGTG GATCACCTGA GGTCGGGAGT TCAAGACCAG CCAGACCAAC ATGGTGAAAC CCTGTCTCTA CTAAAAATAC AAAATTAGCC AGGCGTGGTG GTGCATGCCT GTAATCCCAG CTA=TGGGA GGCTGAGGCA GGAGAATCGC ITrGAACCTGG GAGGCGGAGG TlGCAGTGAG CCGAGATCGC ACCATrACAC TCCAGCCTGG GCAACAAGAG CAAAACTCCC TCTCTCTCAA AAAAAAAAAA AAAAAAAAAA AAGAAGGAAA AGAAAACCAT GGACC7CCAG ACCCTGAGAC WO 00/09525 PCTIUS99/17712 EPI-109 82 CCCAGGCCCC AGCCCTrGAGA TCCTGACATC TTAAAGATCC CAGGCCCTAA GATACAAGAC C7rGACCCAA AGCCAGCCTF GGGACCCTGG CTGTACAAAC CCAAGAC~rC CAGGACCTAG ACCCCGAGCC CTGAGGCCCT ATGTCTCACT CCCAACATCG AAAACCCTGA CACCTCAGAT CCTGAGCCTG CGCCTGTACG ACTCCAAGAC CCTCACTTCC AAAGCCAGGC CCAAAGCCCT GAGACCAGAA GACTrCAAAC CCTGGTrCTr GGGCCTAACT CCAAAGACCC TGGATCTCAA ATITCCAACTT CTAGCTrCTGA GACTCCAGCC CTCACCCATG AGFI7CCTGAA CTTGAACCCA GAGACCCCAT CTCTAAGACTr TCAGCCTrGA GATCCAGGGC CTGACCCTAG ACTCGAGCCC ACAGACCTCA GATACTGTCT GTAAAACCCC AGCTCTGGTG GGGAGCAGTG GCTCACTCCT GTAATCCCAA GGCAGGGGAG GCCAAGGCAG AAGGACCTCT TGAGGCCATG AGTrGAGAC AGCCTGGGCA GCATAGCAAG ACTCTGTXTrC rrAA'rrA'rA 7rA7rAT7AT TA'fTr=GG AGACAGAGTC TCGCGCTCTG 1TGCCCAGGC TAGAGTGCAA TGGTGCCAT' TCGGCTGCT GGAACCTCCG CCTCCTGGGC TCAAGCGATT CTCCTGCCTC AGCCTCCTGA GTAGCTGGGA CTrCAGGTGC ACACTGCCAC ACCCGGATAA TflTTTGTA TrrAGTAcA CACAGGGn71 CACCGTGTrG CCCAGGCTGG TCACAAACTC CTGAGCTCAG GCCATCCGCC CGCCTCGGCC TCCCAAAGCG CTGGGATAAC AGGCGTGACG CCGCGCCTGG CTTCTTAATr GTTCTAACAG CAGCGACAAC AACAAAAACC CAGCTCTGAG ATTCCAGCCC CGGCGACTCT AACAGTCCCA GGCCCGATCC CTCACCTAGA ACCGAGATGC CAGCCCTGAC TCCACAGACT TCACCCCCAA CCCCCACACT CAGCTCTGGA AGCCCGTCCT GACTCCAGCC TCCATI=CG GAACCCCACA GCCTGAAGAG CTCCCGGCCT AAACACTTCA CCCCACGCGC CACAGTCCCC CTGTGAATAT GCAGCCCCGA 'ITCAGCTGCA GCTCCACAGC ACCCCTGCCC TGCACCCCCG CTGCACCCCC TACCTGTGAC TCACCTCTCT CCTrCTCCCCA CAGATGTCCC GCCTGGCCCT GCCCCAGCCA CCCCCGGACC CGCCGGCGCC CCCGCTGGCG CCCCCCTCCT CAGCCTGGGG GGGCATCAGG GCCGCCCACG CCATCCTGGG GGGGCTGCAC CTGACACT~rG ACTGGGCCGT GAGGGGACTG CTGCTGCTGA AGACTCGGCT GTGACCCGGG GCCCAAAGCC ACCACCGTCC TrCCAAAGCC AGAT=TAT'r TA'I=AM~A 1TCAGTACr GGGGGCGAAA CAGCCAGGTG ATCCCCCCGC CAT7ATCTCC CCCTAGTFAG AGACAGTCCT TCCGTGAGGC CTGGGGGGCA TCTGTGCCTr ATITATACT A71rAITCA GGAGCAGGGG TGGGAGGCAG GTGGACTCCT GGGTCCCCGA GGAGGAGGGG ACTGGGGTCC CGGAt~T'r~G GGTCTCCAAG AAGTCTGTCC ACAGACT~rCT GCCCTGGCTC TrCCCCATCT AGGCCTGGGC AGGAACATAT ATrATTATT TAAGCAATI'A CTITTrCATGT TGGGGTGGGG ACGGAGGGGA AAGGGAAGCC TGGG'IFIG TACAAAAATG TGAGAAACCT TTGTGAGACA GAGAACAGGG AAT7AAATGT GTCATACATA TCCACTrGAG Gc3CGA'IMGT CTGAGAGCTG GGGCTGGATG CTTGGGTAAC TGGGGCAGGG CAGGTGGAGG GGAGACCTCC ATTCAGGTGG AGGTCCCGAG TGGGCGGGGC AGCGACTGGG AGATGGGTCG GTCACCCAGA CAGCTCTGTG GAGGCAGGGT CTGAGCC1TG CCTGGGGCCC CGCACTGCAT AGGGCCGM~ GT-rrGrrIr TGAGATGGAG TCTCGCTCTG T'GCCTAGGC TGGAGTGCAG TGAGGCAATC TAAGGTCACT GCAACCTCCA CCTCCCGGGT TCAAGCAATr CTCCTGCCTC AGCCTCCCGA 'FFAGCTGGGA TCACAGGTGT GCACCACCAT GCCCAGCTAA T7ATTrA=r cTTGTATr n7TAGTAGAG ACAGGG ITIC ACCATGT7GG CCAGGCTGGT TrCGAACTCC TGACCTCAGG TGATCCTCCT GCCTCGGCCT CCCAAAGTGC TGGGATrACA GGTGTGAGCC ACCACACCTG ACCCATAGGT CTTCAATAAA TATITAATGG AAcGTTrCCAC AAGTCACCCT GTGATCAACA GTACCCGTAT GGGACAAAGC TGCAAGGTCA AGATGGTrCA TrATGGCTGT GTFCACCATA GCAAACTGGA AACAATCTAG ATATCCAACA GTGAGGG ITA AGCAACATGG TGCATCTGTG GATAGAACGC CACCCAGCCG CCCGGAGCAG GGACTGTCAT TCAGGGAGGC TAAGGAGAGA GGCT-TGCTrG GGATATAGAA AGATATCCTG ACATrGGCCA GGCATGGTGG CTCACGCCTG TAATCCrGGC ACT=GGGAG GACGAAGCGA GTGGATCACT GAAGTCCAAG AG TTGAGAC CGGCCTGCGA GACATGGCAA AACCCTGTCT CAAAAAAGAA AGAATGATGT CCTGACATGA AACAGCAGGC TACAAAACCA CTGCATGCrG TGATCCCAAT ITrGTGTrrr TC'=CTATA TATGGATrAA AACAAAAATC CTAAAGGGAA ATACGCCAAA ATGTI7GACAA TGACTGTCTC CAGGTCAAAG GAGAGAGGTG GGATTGTGGG TGACI=rAA TGTGTATGAT TGTCTGTATT TrACAGAA F7 TCTGCCATGA CTGTGTATI7 TGCATGACAC A=FTAAAAA TAATAAACAC TATIAGA ATAACAGAAT ATCAGCCTCC TCCTCTCCAA AAATAAGCCC TCAGGAGGGG ACAAAGTTGA CCGCTGATTG AGCCTGTCAG GGCTGTGCAC-3' (SEQ. ID NO:2411) Human Adenosine A, Receptor Nucleic Acid and Antisense Oli~onucleotide Fragments 5'-ATGCCGCCCT CCATCtCAGC TFICCAGGCC GCCTACATCG GCATCGAGGT GCTCATCGCC CTGGTCTCTG TGCCCGGGAA CGTGCTGGTG ATCTGGGCGG TGAAGGTGAA CCAGGCGCTG CGGGATGCCA CCYI~CTG=T CATCGTCTCG CTGGCGGTGG CTGATGTGGC CGTGGGTGCC CTGGTCATCC CCCTCGCCAT CCTCATCAAC ATTGGGCCAC AGACCTA=T CCACACCTGC CTCATGGTTG CCTGTCCGGT CCTCATCCTC ACCCAGAGCT CCATCCTGGC CCTGCTGGCA ATrGCTGTGG ACCGCTACCT CCGGGTCAAG ATCCCTCTCC GGTACAAGAT GGTGGTGACC CCCCGGAGGG CGGCGGTGGC CATAGCCGGC TGCTGGATCC TCTCCT7CGT GGTGGGACTG CCCCTATGT fl7GGCTGGAA CAATCTGAGT GCGGTGGAGC GGGCCTGGGC AGCCAACGGC AGCATGGGGG AGCCCGTGAT CAAGTGCGAG F7CGAGAAGG TCATCAGCAT GGAGTACATG GTCTACT7CA ACT7=1TGT GTGGGTGCTG CCCCCGCTC TCC7CATGGT CCTCATCTAC CTGGAGGTCT TCTACCTAAT CCGCAAGCAG CTCAACAAGA AGGTGTCGGC CTCCTCCGGC GACCCGCAGA AGTACTATGG GAAGGAGCTG AAGATCGCCA AGTCGCTGGC CCTCATCCTC TrCCTCI=G CCCI'CAGCTG GCTGCC1TG CACATCCTCA ACTGCATCAC CCTCTTCTGC CCGTCCTGCC ACAAGCCCAG CATC=TACC TACATTGCCA T=TCCTCAC GCACGGCAAC TCGGCCATGA ACCCCATrGT CTATGCCTTC CGCATCCAGA AGTrCCGCGT CACC17CCP AAGAIMGGA ATGACCAMr CCGCTGCCAG CCTGCACCTC CCAITGACGA GGATCTCCCA GAAGAGAGGC CTGATGACTA G ATGAGTGTCA GAAGTGTGAA GGGTGCCTGT TCTGAATCCC AGAGCCTCCT CTCCCTCTGT GAGGCTGGCA GGTGAGGAAG GG717rAACCT CACTGGAAGG AATCCCTGGA GCTAGCGGCT GCTGAAGGCG TCGAGGTGTG GGGGCACTTG GACAGAACAG TCAGGCAGCC GGGAGCTCTG CCAGC1TGG TGACCfI'GGG CCGGGCTGGG AGCGCTGCGG CGGGAGCCGG AGGACTATGA GCTGCCGCGC GTrGTCCAGA GCCCAGCCCA GCCCTACGCG CGCGGCCCGG AGCTCTGTTC CCTGGAACTT TGGGCACTGC CTCTGGGACC CCrGCCGGCC AGCAGGCAGG ATGGTG=TG CCTCGTGCCC CTI'GGTGCCC GTCTGCrGAT GTGCCCAGCC TGTGCCCGCC ATGCCGCCCT CCATCTCAGC TTCCAGGCC GCCTACATCG GCATCGAGGT GCTCATCGCC CTGGTCTCTG TGCCCGGGAA CG3TGCTGGTG ATCTGGGCGG TGAAGGTGAA CCAGGCGCTG CGGGATGCCA CCTTCTGC= CATCGTGTCG CTGGCGGTGG CTGATGTGGC CGTGGGTGCC CTGGTCATCC CCCTCGCCAT CCTCATCAAC ATrGGGCCAC AGACCTACTT CCACACCTGC CTCATGGTTG CCTGTCCGGT CCTCATCCTC ACCCAGAGCT CCATCCTGGC CCrGCTGG1CA ATrGCrGTGG ACCGCTAC~r CCGGGTCAAG ATCCCTCTCC GGTACAAGAT GGTGGTGACC CCCCGGAGGG CGGCGGTGGC CATAGCCGGC TGCTGGATCC TCTCCTTCGT GGTGGGACTG ACCCCTATGT TrGGCTGGAA CAATCTGAGT GCGGTGGAGC GGGCCTGGGC AGCCAACGGC AGCATGGGGG AGCCCGTGAT CAAGTGCGAG TI7CGAGAAGG TCATCAGCAT GGAGTACATG GTCTACT7CA AC=1GT GTGGGTGCTG CCCCCGC'ITC TCCTCATGGT CCTCATCTAC CTGGAGGTCT TCTACCTAAT CCGCAAGCAG CTCAACAAGA AGGTGTCGGC CTC~TCCGGC GACCCGCAGA AGTACTATGG GAAGGAGCTG AAGATCGCCA AGTCGCTGGC CCTCATCCTC TrCCT=rrG CCCTCAGCTG GCTGCCT=G CACATCCTCA ACTGCATCAC CC7T'TrCTGC CCGTCCTGCC ACAAGCCCAG CATCCTACC TACATTGCCA TCT7CCTCAC GCACGGCAAC TCGGCCATGA WO 00/09525 PCT/US99/17712 EPI-109 83 ACCCCATrGT CTATGCCTTC CGCATCCAGA AGTTCCGCGT CACCTTCCTT AAGATTTGGA ATGACCATTT CCGCTGCCAG CCTGCACCTC CCATTGACGA GGATCTCCCA GAAGAGAGGC CTGATGACTA GACCCCGCCT TCCGCTCCCA CCAGCCCACA TCCAGTGGGG TCTCAGTCCA GTCCTCACAT GCCCGCTGTC CCAGGGGTCT CCCTGAGCCT GCCCCAGCTG GGCTGTTGGC TGGGGGCATG GGGGAGGCTC TGAAGAGATA CCCACAGAGT GTGGTCCCTC CACTAGGAGT TAACTACCCT ACACCTCTGG GCCCTGCAGG AGGCCTGGGA GGGCAAGGGT CCTACGGAGG GACCAGGTGT CTAGAGGCAA CAGTGTTCTG AGCCCCCACC TGCCTGACCA TCCCATGAGC AGTCCAGCGC TTCAGGGCTG GGCAGGTCCT GGGGAGGCTG AGACTGCAGA GGAGCCACCT GGGCTGGGAG AAGGTGCTTG GGCTTCTGCG GTGAGGCAGG GGAGTCTGCT TGTCTTAGAT GTTGGTGGTG CAGCCCCAGG ACCAAGCTrA AGGAGAGGAG AGCATCTGCT CTGAGACGGA TGGAAGGAGA GAGGTTGAGG ATGCACTGGC CTGTrCTGTA GGAGAGACTG GCCAGAGGCA GCTAAGGGGC AGGAATCAAG GAGCCTCCGT TCCCACCTCT GAGGACTCTG GACCCCAGGC CATACCAGGT GCTAGGGTGC CTGCTCTCCT TGCCCTGGGC CAGCCCAGGA TTGTACGTGG GAGAGGCAGA AAGGGTAGGT TCAGTAATCA TTTCTGATGA TTrGCTGGAG TGCTGGCTCC ACGCCCTGGG GAGTGAGCTT GGTGCGGTAG GTGCTGGCCT CAAACAGCCA CGAGGTGGTA GCTCTGAGCC CTCCTTCTTG CCCTGAGCTT TCCGGGGAGG AGCCTGGAGT GTAATTACCT GTCATCTGGG CCACCAGCTC CACTGGCCCC CGTTGCCGGG CCTGGACTGT CCTAGGTGAC CCCATCTCTG CTGCT7CTGG GCCTGATGGA GAGGAGAACA CTAGACATGC CAACTCGGGA GCATTCTGCC TGCCTGGGAA CGGGGTGGAC GAGGGAGTGT CTGTAAGGAC TCAGTGTTGA CTGTAGGCGC CCCTGGGGTG GGTTTAGCAG GCTGCAGCAG GCAGAGGAGG AGTACCCCCC TGAGAGCATG TGGGGGAAGG CCTTGCTGTC ATGTGAATCC CTCAATACCC CTAGTATCTG GCTGGGTTTT CAGGGGCTTT GGAAGCTCTG TTGCAGGTGT CCGGGGGTCT AGGACTTTAG GGATCTGGGA TCTGGGGAAG GACCAACCCA TGCCCTGCCA AGCCTGGAGC CCCTGTGTTG GGGGGCAAGG TGGGGGAGCC TGGAGCCCCT GTGTGGGAGG GCGAGGCGGG GGAGCCTGGA GCCCCTGTGT GGGAGGGCGA GGCGGGGGAT CCTGGAGCCC CTGTGTCGGG GGGCGAGGGA GGGGAGGTGG CCGTCGGTTG ACCTTCTGAA CATGAGTGTC AACTCCAGGA CTTGCTTCCA AGCCCTTCCC TCTGTTGGAA ATTGGGTGTG CCCTGGCTCC CAAGGGAGGC CCATGTGACT AATAAAAAAC TGTGAACCCT CGCAT17GTG TI iAATAAA AGAATCTGGA AGATAAATAG TCTTGAAGAG AGACAAAGGA AGGAAAATTT AAATCCTTAG ATTCAAGCAG AAGAATTCCA TGTGGAAGGT TTGGGTTGTT GTTGTTGTTG 'TTTGGTGTGT T-TGTT TTTGTITTT TGTFITFITT TGAGATGGAG TCTCGCTGTG TTACCGGGAG CGACAGAGCC GCACGGCCGA GTCGAGTCCC AGCCAGCTAC CATCCCTCTG GAGCTTACCG GCCGGCCTTG GCTTCCCCAG GAATCCCTGG AGCTAGCGGC TGCTGAAGGC GTCGAGGTGT GGGGGCACTT GGACAGAACA GTCAGGCAGC CGGGAGCTCT GCCAGCTTTG GTGACCTTGG GTGCTTGCCT CGTGCCCCTT GGTGCCCGTC TGCTGATGTG CCCAGCCTGT GCCCGCCATG CCGCCCTCCA TCTCAGCTTT CCAGGCCGCC TACATCGGCA TCGAGGTGCT CATCGCCCTG GTCTCTGTGC CCGGGAACGT GCTGGTGATC TGGGCGGTGA AGGTGAACCA GGCGCTGCGG GATGCCACCT TCTGCTTCAT CGTGTCGCTG GCGGTGGCTG ATGTGGCCGT GGGTGCCCTG GTCATCCCCC TCGCCATCCT CATCAACATT GGGCCACAGA CCTACTTCCA CACCTGCCTC ATGGTTGCCT GTCCGGTCCT CATCCTCACC CAGAGCTCCA TCCTGGCCCT GCTGGCAATT GCTGTGGACC GCTACCTCCG GGTCAAGATC CCTCTCCGGT ACAAGATGGT GGTGACCCCC CGGAGGGCGG CGGTGGCCAT AGCCGGCTGC TGGATCCTCT CCTTCGTGGT GGGACTGACC CCTATGTTTG GCTGGAACAA TCTGAGTGCG GTGGAGCGGG CCTGGGCAGC CAACGGCAGC ATGGGGGAGC CCGTGATCAA GTGCGAGTTC GAGAAGGTCA TCAGCATGGA GTACATGGTC TACTTCAACT TCTTTGTGTG GGTGCTGCCC CCGCTTCTCC TCATGGTCCT CATCTACCTG GAGGTCTTCT ACCTAATCCG CAAGCAGCTC AACAAGAAGG TGTCGGCCTC CTCCGGCGAC CCGCAGAAGT ACTATGGGAA GGAGCTGAAG ATCGCCAAGT CGCTGGCCCT CATCCTCTTC CTCTTTGCCC TCAGCTGGCT GCCTTTGCAC ATCCTCAACT GCATCACCCT CTTCTGCCCG TCCTGCCACA AGCCCAGCAT CCTTACCTAC ATTGCCATCT TCCTCACGCA CGGCAACTCG GCCATGAACC CCATTGTCTA TGCCTTCCGC ATCCAGAAGT TCCGCGTCAC CTTCCT-AAG ATTTGGAATG ACCATTTCCG CTGCCAGCCT GCACCTCCCA TTGACGAGGA TCTCCCAGAA GAGAGGCCTG ATGACTAGAC CCCGCCTTCC GCTCCCACCG CCCACATCCA GTGGGGTCTC AGTCCAGTCC TCACATGCCC GCTGTCCCAG GGGTCTCCCT GAGCCTGCCC CAGCTGGGCT GTTGGCTGGG GGCATGGGGG AGGCTCTGAA GAGATACCCA CAGAGTGTGG TCCCTCCACT AGGAGTTAAC TACCCTACAC CTCTGGGCCC TGCAGGAGGC CTGGGAGGGC AAGGGTCCTA CGGAGGGACC AGGTGTCTAG AGGCAACAGT GTTCTGAGCC CCCACCTGCC TGACCATCCC ATGAGCAGTC CAGAGCTTCA GGGCTGGGCA GGTCCTGGGG AGGCTGAGAC TGCAGAGGAG CCACCTGGGC TGGGAGAAGG TGCTTGGGCT TCTGCGGTGA GGCAGGGGAG TCTGCTTGTC TTAGATGTTG GTGGTGCAGC CCCAGGACCA AGCTTAAGGA GAGGAGAGCA TCTGCTCTGA GACGGATGGA AGGAGAGAGG TTGAGGATGC ACTGGCCTGT TCTGTAGGAG AGACTGGCCA GA GAT GGA GGG CGG CAT GGC GGG G CGG GTC GCC GG GGC GGG CBC BGG C GGC GGG CBC GC GGC CTG G GGB GGG CGG C GBT GGB GGG GG CTG GGC GC GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC ATGCCGCCCT CCATCTCAGC TrTCCAGGCC GCCTACATCG GCATCGAGGT GCTCATCGCC CTGGTCTCTG TGCCCGGGAA CGTGCTGGTG ATCTGGGCGG TGAAGGTGAA CCAGGCGCTG CGGGATGCCA CCTTCTGCTT CATCGTCTCG CTGGCGGTGG CTGATGTGGC CGTGGGTGCC CTGGTCATCC CCCTCGCCAT CCTCATCAAC ATTGGGCCAC AGACCTACTT CCACACCTGC CTCATGGTTG CCTGTCCGGT CCTCATCCTC ACCCAGAGCT CCATCCTGGC CCTGCTGGCA ATTGCTGTGG ACCGCTACCT CCGGGTCAAG ATCCCTCTCC GGTACAAGAT GGTGGTGACC CCCCGGAGGG CGGCGGTGGC CATAGCCGGC TGCTGGATCC TCTCCTTCGT GGTGGGACTG ACCCCTATGT TTGGCTGGAA CAATCTGAGT GCGGTGGAGC GGGCCTGGGC AGCCAACGGC AGCATGGGGG AGCCCGTGAT CAAGTGCGAG TTCGAGAAGG TCATCAGCAT GGAGTACATG GTCTACTTCA ACTTCTTTGT GTGGGTGCTG CCCCCGCTTC TCCTCATGGT CCTCATCTAC CTGGAGGTCT TCTACCTAAT CCGCAAGCAG CTCAACAAGA AGGTGTCGGC CTCCTCCGGC GACCCGCAGA AGTACTATGG GAAGGAGCTG AAGATCGCCA AGTCGCTGGC CCTCATCCTC TTCCTCTITG CCCTCAGCTG GCTGCCTTTG CACATCCTCA ACTGCATCAC CCTCTTCTGC CCGTCCTGCC ACAAGCCCAG CATCCTTACC TACATTGCCA TCTTCCTCAC GCACGGCAAC TCGGCCATGA ACCCCATTGT CTATGCCTTC CGCATCCAGA AGTTCCGCGT CACCTrCCTT AAGATTTGGA ATGACCAT CCGCTGCCAG CCTGCACCTC CCATTGACGA GGATCTCCCA GAAGAGAGGC CTGATGACTA G ATGAGTGTCA GAAGTGTGAA GGGTGCCTGT TCTGAATCCC AGAGCCTCCT CTCCCTCTGT GAGGCTGGCA GGTGAGGAAG GGTTTAACCT CACTGGAAGG AATCCCTGGA GCTAGCGGCT GCTGAAGGCG TCGAGGTGTG GGGGCACTTG GACAGAACAG TCAGGCAGCC GGGAGCTCTG CCAGCTTTGG TGACCTTGGG CCGGGCTGGG AGCGCTGCGG CGGGAGCCGG AGGACTATGA GCTGCCGCGC GTTGTCCAGA GCCCAGCCCA GCCCTACGCG CGCGGCCCGG AGCTCTGTTC CCTGGAACTT TGGGCACTGC CTCTGGGACC CCTGCCGGCC AGCAGGCAGG ATGGTGCTTG CCTCGTGCCC CTTGGTGCCC GTCTGCTGAT GTGCCCAGCC TGTGCCCGCC ATGCCGCCCT CCATCTCAGC TTCCAGGCC GCCTACATCG GCATCGAGGT GCTCATCGCC CTGGTCTCTG TGCCCGGGAA CGTGCTGGTG ATCTGGGCGG TGAAGGTGAA CCAGGCGCTG CGGGATGCCA CCTTCTGCTT CATCGTGTCG CTGGCGGTGG CTGATGTGGC CGTGGGTGCC CTGGTCATCC CCCTCGCCAT CCTCATCAAC ATTGGGCCAC AGACCTACTT CCACACCTGC CTCATGGTTG CCTGTCCGGT CCTCATCCTC ACCCAGAGCT CCATCCTGGC CCTGCTGGCA ATTGCTGTGG ACCGCTACCT CCGGGTCAAG ATCCCTCTCC GGTACAAGAT GGTGGTGACC CCCCGGAGGG CGGCGGTGGC WO 00/09525 PCT/US99/17712 EPI-109 84 CATAGCCGGC TGCTGGATCC TCTCCTTCGT GGTGGGACTG ACCCCTATGT TTGGCTGGAA CAATCTGAGT GCGGTGGAGC GGGCCTGGGC AGCCAACGGC AGCATGGGGG AGCCCGTGAT CAAGTGCGAG TTCGAGAAGG TCATCAGCAT GGAGTACATG GTCTACTrCA A=CTTTGT GTGGGTGCTG CCCCCGCTTC TCCTCATGGT CCTCATCTAC CTGGAGGTCT TCTACCTAAT CCGCAAGCAG CTCAACAAGA AGGTGTCGGC CTCCTCCGGC GACCCGCAGA AGTACTATGG GAAGGAGCTG AAGATCGCCA AGTCGCTGGC CCTCATCCTC TTCCTCTTTG CCCTCAGCTG GCTGCCTTG CACATCCTCA ACTGCATCAC CCTCTTCTGC CCGTCCTGCC ACAAGCCCAG CATCCTTACC TACATTGCCA TCTrCCTCAC GCACGGCAAC TCGGCCATGA ACCCCATTGT CTATGCCTTC CGCATCCAGA AGTTCCGCGT CACCTTCCTT AAGATTTGGA ATGACCATTT CCGCTGCCAG CCTGCACCTC CCATTGACGA GGATCTCCCA GAAGAGAGGC CTGATGACTA GACCCCGCCT TCCGCTCCCA CCAGCCCACA TCCAGTGGGG TCTCAGTCCA GTCCTCACAT GCCCGCTGTC CCAGGGGTCT CCCTGAGCCT GCCCCAGCTG GGCTGTTGGC TGGGGGCATG GGGGAGGCTC TGAAGAGATA CCCACAGAGT GTGGTCCCTC CACTAGGAGT TAACTACCCT ACACCTCTGG GCCCTGCAGG AGGCCTGGGA GGGCAAGGGT CCTACGGAGG GACCAGGTGT CTAGAGGCAA CAGTGTTCTG AGCCCCCACC TGCCTGACCA TCCCATGAGC AGTCCAGCGC TTCAGGGCTG GGCAGGTCCT GGGGAGGCTG AGACTGCAGA GGAGCCACCT GGGCTGGGAG AAGGTGCTrG GGCTTCTGCG GTGAGGCAGG GGAGTCTGCT TGTCTrAGAT GTTGGTGGTG CAGCCCCAGG ACCAAGCTTA AGGAGAGGAG AGCATCTGCT CTGAGACGGA TGGAAGGAGA GAGGTTGAGG ATGCACTGGC CTGTTCTGTA GGAGAGACTG GCCAGAGGCA GCTAAGGGGC AGGAATCAAG GAGCCTCCGT TCCCACCTCT GAGGACTCTG GACCCCAGGC CATACCAGGT GCTAGGGTGC CTGCTCTCCT TGCCCTGGGC CAGCCCAGGA TTGTACGTGG GAGAGGCAGA AAGGGTAGGT TCAGTAATCA TTTCTGATGA ITTGCTGGAG TGCTGGCTCC ACGCCCTGGG GAGTGAGCTT GGTGCGGTAG GTGCTGGCCT CAAACAGCCA CGAGGTGGTA GCTCTGAGCC CTCCTTCTTG CCCTGAGCTT TCCGGGGAGG AGCCTGGAGT GTAATTACCT GTCATCTGGG CCACCAGCTC CACTGGCCCC CGTT'GCCGGG CCTGGACTGT CCTAGGTGAC CCCATCTCTG CTGCTTCTGG GCCTGATGGA GAGGAGAACA CTAGACATGC CAACTCGGGA GCATTCTGCC TGCCTGGGAA CGGGGTGGAC GAGGGAGTGT CTGTAAGGAC TCAGTGTTGA CTGTAGGCGC CCCTGGGGTG GGTTTAGCAG GCTGCAGCAG GCAGAGGAGG AGTACCCCCC TGAGAGCATG TGGGGGAAGG CCTTGCTGTC ATGTGAATCC CTCAATACCC CTAGTATCTG GCTGGGTTTT CAGGGGCTTT GGAAGCTCTG TTGCAGGTGT CCGGGGGTCT AGGACTAG GGATCTGGGA TCTGGGGAAG GACCAACCCA TGCCCTGCCA AGCCTGGAGC CCCTGTGTTG GGGGGCAAGG TGGGGGAGCC TGGAGCCCCT GTGTGGGAGG GCGAGGCGGG GGAGCCTGGA GCCCCTGTGT GGGAGGGCGA GGCGGGGGAT CCTGGAGCCC CTGTGTCGGG GGGCGAGGGA GGGGAGGTGG CCGTCGGTTG ACCTTCTGAA CATGAGTGTC AACTCCAGGA CTrGCTTCCA AGCCCTTCCC TCTGTTGGAA ATTGGGTGTG CCCTGGCTCC CAAGGGAGGC CCATGTGACT AATAAAAAAC TGTGAACCCT CGCATTrGTG TTTTAATAAA AGAATCTGGA AGATAAATAG TCTTGAAGAG AGACAAAGGA AGGAAAATTT AAATCCTTAG ATTCAAGCAG AAGAATTCCA TGTGGAAGGT TTGGGTTGTT GTTGTTGTTG TTTGGTGTGT TTTTGTT TTTGTITr1 TGTI111 TGAGATGGAG TCTCGCTGTG TTACCGGGAG CGACAGAGCC GCACGGCCGA GTCGAGTCCC AGCCAGCTAC CATCCCTCTG GAGCTTACCG GCCGGCCTTG GCTTCCCCAG GAATCCCTGG AGCTAGCGGC TGCTGAAGGC GTCGAGGTGT GGGGGCACTT GGACAGAACA GTCAGGCAGC CGGGAGCTCT GCCAGCTTG GTGACCTTGG GTGCTTGCCT CGTGCCCCTT GGTGCCCGTC TGCTGATGTG CCCAGCCTGT GCCCGCCATG CCGCCCTCCA TCTCAGCTT CCAGGCCGCC TACATCGGCA TCGAGGTGCT CATCGCCCTG GTCTCTGTGC CCGGGAACGT GCTGGTGATC TGGGCGGTGA AGGTGAACCA GGCGCTGCGG GATGCCACCT TCTGCTTCAT CGTGTCGCTG GCGGTGGCTG ATGTGGCCGT GGGTGCCCTG GTCATCCCCC TCGCCATCCT CATCAACATT GGGCCACAGA CCTACT7CCA CACCTGCCTC ATGGTTGCCT GTCCGGTCCT CATCCTCACC CAGAGCTCCA TCCTGGCCCT GCTGGCAATT GCTGTGGACC GCTACCTCCG GGTCAAGATC CCTCTCCGGT ACAAGATGGT GGTGACCCCC CGGAGGGCGG CGGTGGCCAT AGCCGGCTGC TGGATCCTCT CCTTCGTGGT GGGACTGACC CCTATGTTTG GCTGGAACAA TCTGAGTGCG GTGGAGCGGG CCTGGGCAGC CAACGGCAGC ATGGGGGAGC CCGTGATCAA GTGCGAGTTC GAGAAGGTCA TCAGCATGGA GTACATGGTC TACTTCAACT TCTTGTGTG GGTGCTGCCC CCGCTTCTCC TCATGGTCCT CATCTACCTG GAGGTCTTCT ACCTAATCCG CAAGCAGCTC AACAAGAAGG TGTCGGCCTC CTCCGGCGAC CCGCAGAAGT ACTATGGGAA GGAGCTGAAG ATCGCCAAGT CGCTGGCCCT CATCCTCTT'C CTCTGCCC TCAGCTGGCT GCCTGCAC ATCCTCAACT GCATCACCCT CTTCTGCCCG TCCTGCCACA AGCCCAGCAT CCTTACCTAC ATTGCCATCT TCCTCACGCA CGGCAACTCG GCCATGAACC CCATTGTCTA TGCCTTCCGC ATCCAGAAGT TCCGCGTCAC CTTCCTTAAG ATTTGGAATG ACCATTTCCG CTGCCAGCCT GCACCTCCCA TTGACGAGGA TCTCCCAGAA GAGAGGCCTG ATGACTAGAC CCCGCCTTCC GCTCCCACCG CCCACATCCA GTGGGGTCTC AGTCCAGTCC TCACATGCCC GCTGTCCCAG GGGTCTCCCT GAGCCTGCCC CAGCTGGGCT GTTGGCTGGG GGCATGGGGG AGGCTCTGAA GAGATACCCA CAGAGTGTGG TCCCTCCACT AGGAGTTAAC TACCCTACAC CTCTGGGCCC TGCAGGAGGC CTGGGAGGGC AAGGGTCCTA CGGAGGGACC AGGTGTCTAG AGGCAACAGT GTTCTGAGCC CCCACCTGCC TGACCATCCC ATGAGCAGTC CAGAGCTTCA GGGCTGGGCA GGTCCTGGGG AGGCTGAGAC TGCAGAGGAG CCACCTGGGC TGGGAGAAGG TGCTTGGGCT TCTGCGGTGA GGCAGGGGAG TCTGCTTGTC TTAGATGTTG GTGGTGCAGC CCCAGGACCA AGCTTAAGGA GAGGAGAGCA TCTGCTCTGA GACGGATGGA AGGAGAGAGG TTGAGGATGC ACTGGCCTGT TCTGTAGGAG AGACTGGCCA GA -3'(FRAG.NO:_)(SEQ.NO:2423) 5'-CGCATTTGTG TITTAATAAA AGAATCTGGA AGATAAATAG TCTTGAAGAG AGACAAAGGA AGGAAAATTT AAATCCTTAG ATTCAAGCAG AAGAATTCCA TGTGGAAGGT TrGGGTTGTr GTIGTTGTTG TTTGGTGTGT IT=GTT 'TTGIT1I TG1TIT I TGAGATGGAG TCTCGCTGTG TTACCGGGAG CGACAGAGCC GCACGGCCGA GTCGAGTCCC AGCCAGCTAC CATCCCTCTG GAGCTTACCG GCCGGCCTTG GCTTCCCCAG GAATCCCTGG AGCTAGCGGC TGCTGAAGGC GTCGAGGTGT GGGGGCACTT GGACAGAACA GTCAGGCAGC CGGGAGCTCT GCCAGCTG GTGACCTTGG GTGCTTGCCT CGTGCCCCTT GGTGCCCGTC TGCTGATGTG CCCAGCCTGT GCCCGCCATG CCGCCCTCCA TCTCAGCTTT CCAGGCCGCC TACATCGGCA TCGAGGTGCT CATCGCCCTG GTCTCTGTGC CCGGGAACGT GCTGGTGATC TGGGCGGTGA AGGTGAACCA GGCGCTGCGG GATGCCACCT TCTGCTTCAT CGTGTCGCTG GCGGTGGCTG ATGTGGCCGT GGGTGCCCTG GTCATCCCCC TCGCCATCCT CATCAACATT GGGCCACAGA CCTACrTCCA CACCTGCCTC ATGGTTGCCT GTCCGGTCCT CATCCTCACC CAGAGCTCCA TCCTGGCCCT GCTGGCAATT GCTGTGGACC GCTACCTCCG GGTCAAGATC CCTCTCCGGT ACAAGATGGT GGTGACCCCC CGGAGGGCGG CGGTGGCCAT AGCCGGCTGC TGGATCCTCT CCTTCGTGGT GGGACTGACC CCTATGITTG GCTGGAACAA TCTGAGTGCG GTGGAGCGGG CCTGGGCAGC CAACGGCAGC ATGGGGGAGC CCGTGATCAA GTGCGAGTTC GAGAAGGTCA TCAGCATGGA GTACATGGTC TACTTCAACT TCTTTGTGTG GGTGCTGCCC CCGCTTCTCC TCATGGTCCT CATCTACCTG GAGGTCTTCT ACCTAATCCG CAAGCAGCTC AACAAGAAGG TGTCGGCCTC CTCCGGCGAC CCGCAGAAGT ACTATGGGAA GGAGCTGAAG ATCGCCAAGT CGCTGGCCCT CATCCTCTTC CTCTGCCC TCAGCTGGCT GCCTTTGCAC ATCCTCAACT GCATCACCCT CTTCTGCCCG TCCTGCCACA AGCCCAGCAT CCTTACCTAC ATTGCCATCT TCCTCACGCA CGGCAACTCG GCCATGAACC CCATTGTCTA TGCCTTCCGC ATCCAGAAGT TCCGCGTCAC CTTCCTTAAG ATTTGGAATG ACCATTICCG CTGCCAGCCT GCACCTCCCA TTGACGAGGA TCTCCCAGAA GAGAGGCCTG ATGACTAGAC CCCGCCTTCC WO 00/09525 PCT/US99/17712 EPI-109 85 GCTCCCACCG CCCACATCCA GTGGGGTCTC AGTCCAGTCC TCACATGCCC GCTGTCCCAG GGGTCTCCCT GAGCCTGCCC CAGCTGGGCT GTTGGCTGGG GGCATGGGGG AGGCTCTGAA GAGATACCCA CAGAGTGTGG TCCCTCCACT AGGAGTTAAC TACCCTACAC CTCTGGGCCC TGCAGGAGGC CTGGGAGGGC AAGGGTCCTA CGGAGGGACC AGGTGTCTAG AGGCAACAGT GTTCTGAGCC CCCACCTGCC TGACCATCCC ATGAGCAGTC CAGAGCTrCA GGGCTGGGCA GGTCCTGGGG AGGCTGAGAC TGCAGAGGAG CCACCTGGGC TGGGAGAAGG TGCTTGGGCT TCTGCGGTGA GGCAGGGGAG TCTGCTTGTC TTAGATGTTG GTGGTGCAGC CCCAGGACCA AGCTTAAGGA GAGGAGAGCA TCTGCTCTGA GACGGATGGA AGGAGAGAGG TTGAGGATGC ACTGGCCTGT TCTGTAGGAG AGACTGGCCA GA -3' (FRAG. NO:_)(SEQ. ID NO: 2434) 5'- ATGAGTGTCA GAAGTGTGAA GGGTGCCTGT TCTGAATCCC AGAGCCTCCT CTCCCTCTGT GAGGCTGGCA GGTGAGGAAG GGTTAACCT CACTGGAAGG AATCCCTGGA GCTAGCGGCT GCTGAAGGCG TCGAGGTGTG GGGGCACTTG GACAGAACAG TCAGGCAGCC GGGAGCTCTG CCAGCITGG TGACCTTGGG CCGGGCTGGG AGCGCTGCGG CGGGAGCCGG AGGACTATGA GCTGCCGCGC GTTGTCCAGA GCCCAGCCCA GCCCTACGCG CGCGGCCCGG AGCTCTGTrC CCTGGAACTT TGGGCACTGC CTCTGGGACC CCTGCCGGCC AGCAGGCAGG ATGGTGCTTG CCTCGTGCCC CTTGGTGCCC GTCTGCTGAT GTGCCCAGCC TGTGCCCGCC ATGCCGCCCT CCATCTCAGC TTTCCAGGCC GCCTACATCG GCATCGAGGT GCTCATCGCC CTGGTCTCTG TGCCCGGGAA CGTGCTGGTG ATCTGGGCGG TGAAGGTGAA CCAGGCGCTG CGGGATGCCA CCTTCTGCTT CATCGTGTCG CTGGCGGTGG CTGATGTGGC CGTGGGTGCC CTGGTCATCC CCCTCGCCAT CCTCATCAAC ATTGGGCCAC AGACCTACTT CCACACCTGC CTCATGGTTG CCTGTCCGGT CCTCATCCTC ACCCAGAGCT CCATCCTGGC CCTGCTGGCA ATTGCTGTGG ACCGCTACCT CCGGGTCAAG ATCCCTCTCC GGTACAAGAT GGTGGTGACC CCCCGGAGGG CGGCGGTGGC CATAGCCGGC TGCTGGATCC TCTCCTTCGT GGTGGGACTG ACCCCTATGT TrGGCTGGAA CAATCTGAGT GCGGTGGAGC GGGCCTGGGC AGCCAACGGC AGCATGGGGG AGCCCGTGAT CAAGTGCGAG TTCGAGAAGG TCATCAGCAT GGAGTACATG GTCTACTTCA ACTrCTGT GTGGGTGCTG CCCCCGCTTC TCCTCATGGT CCTCATCTAC CTGGAGGTCT TCTACCTAAT CCGCAAGCAG CTCAACAAGA AGGTGTCGGC CTCCTCCGGC GACCCGCAGA AGTACTATGG GAAGGAGCTG AAGATCGCCA AGTCGCTGGC CCTCATCCTC TTCCTCTTTG CCCTCAGCTG GCTGCCTTG CACATCCTCA ACTGCATCAC CCTCTTCTGC CCGTCCTGCC ACAAGCCCAG CATCCTTACC TACATTGCCA TCTTCCTCAC GCACGGCAAC TCGGCCATGA ACCCCATTGT CTATGCCTTC CGCATCCAGA AGTTCCGCGT CACCTTCCTT AAGATTTGGA ATGACCATTT CCGCTGCCAG CCTGCACCTC CCATTGACGA GGATCTCCCA GAAGAGAGGC CTGATGACTA GACCCCGCCT TCCGCTCCCA CCAGCCCACA TCCAGTGGGG TCTCAGTCCA GTCCTCACAT GCCCGCTGTC CCAGGGGTCT CCCTGAGCCT GCCCCAGCTG GGCTGTTGGC TGGGGGCATG GGGGAGGCTC TGAAGAGATA CCCACAGAGT GTGGTCCCTC CACTAGGAGT TAACTACCCT ACACCTCTGG GCCCTGCAGG AGGCCTGGGA GGGCAAGGGT CCTACGGAGG GACCAGGTGT CTAGAGGCAA CAGTGTTCTG AGCCCCCACC TGCCTGACCA TCCCATGAGC AGTCCAGCGC TTCAGGGCTG GGCAGGTCCT GGGGAGGCTG AGACTGCAGA GGAGCCACCT GGGCTGGGAG AAGGTGCTTG GGCTTCTGCG GTGAGGCAGG GGAGTCTGCT TGTCTTAGAT GTTGGTGGTG CAGCCCCAGG ACCAAGCTrA AGGAGAGGAG AGCATCTGCT CTGAGACGGA TGGAAGGAGA GAGGT7GAGG ATGCACTGGC CTGTTCTGTA GGAGAGACTG GCCAGAGGCA GCTAAGGGGC AGGAATCAAG GAGCCTCCGT TCCCACCTCT GAGGACTCTG GACCCCAGGC CATACCAGGT GCTAGGGTGC CTGCTCTCCT TGCCCTGGGC CAGCCCAGGA TTGTACGTGG GAGAGGCAGA AAGGGTAGGT TCAGTAATCA TTrCTGATGA TTGCTGGAG TGCTGGCTCC ACGCCCTGGG GAGTGAGCTT GGTGCGGTAG GTGCTGGCCT CAAACAGCCA CGAGGTGGTA GCTCTGAGCC CTCCTTCTTG CCCTGAGCTT TCCGGGGAGG AGCCTGGAGT GTAATTACCT GTCATCTGGG CCACCAGCTC CACTGGCCCC CGTTGCCGGG CCTGGACTGT CCTAGGTGAC CCCATCTCTG CTGCTTCTGG GCCTGATGGA GAGGAGAACA CTAGACATGC CAACTCGGGA GCATTCTGCC TGCCTGGGAA CGGGGTGGAC GAGGGAGTGT CTGTAAGGAC TCAGTGTTGA CTGTAGGCGC CCCTGGGGTG GGTTAGCAG GCTGCAGCAG GCAGAGGAGG AGTACCCCCC TGAGAGCATG TGGGGGAAGG CCTTGCTGTC ATGTGAATCC CTCAATACCC CTAGTATCTG GCTGGGTT CAGGGGC1T' GGAAGCTCTG TTGCAGGTGT CCGGGGGTCT AGGAC'ITTAG GGATCTGGGA TCTGGGGAAG GACCAACCCA TGCCCTGCCA AGCCTGGAGC CCCTGTGTTG GGGGGCAAGG TGGGGGAGCC TGGAGCCCCT GTGTGGGAGG GCGAGGCGGG GGAGCCTGGA GCCCCTGTGT GGGAGGGCGA GGCGGGGGAT CCTGGAGCCC CTGTGTCGGG GGGCGAGGGA GGGGAGGTGG CCGTCGGTTG ACCTTCTGAA CATGAGTGTC AACTCCAGGA CTTGCTTCCA AGCCCTTCCC TCTGTTGGAA ATTGGGTGTG CCCTGGCTCC CAAGGGAGGC CCATGTGACT AATAAAAAAC TGTGAACCCT -3' (FRAG. NO:_)(SEQ. ID NO: 2433) 5'- ATGCCGCCCT CCATCTCAGC TCCAGGCC GCCTACATCG GCATCGAGGT GCTCATCGCC CTGGTCTCTG TGCCCGGGAA CGTGCTGGTG ATCTGGGCGG TGAAGGTGAA CCAGGCGCTG CGGGATGCCA CCTTCTGCTT CATCGTCTCG CTGGCGGTGG CTGATGTGGC CGTGGGTGCC CTGGTCATCC CCCTCGCCAT CCTCATCAAC ATTGGGCCAC AGACCTACTT CCACACCTGC CTCATGGTTG CCTGTCCGGT CCTCATCCTC ACCCAGAGCT CCATCCTGGC CCTGCTGGCA ATTGCTGTGG ACCGCTACCT CCGGGTCAAG ATCCCTCTCC GGTACAAGAT GGTGGTGACC CCCCGGAGGG CGGCGGTGGC CATAGCCGGC TGCTGGATCC TCTCCTTCGT GGTGGGACTG ACCCCTATGT TTGGCTGGAA CAATCTGAGT GCGGTGGAGC GGGCCTGGGC AGCCAACGGC AGCATGGGGG AGCCCGTGAT CAAGTGCGAG TTCGAGAAGG TCATCAGCAT GGAGTACATG GTCTACTTCA ACTrC'TTGT GTGGGTGCTG CCCCCGCTTC TCCTCATGGT CCTCATCTAC CTGGAGGTCT TCTACCTAAT CCGCAAGCAG CTCAACAAGA AGGTGTCGGC CTCCTCCGGC GACCCGCAGA AGTACTATGG GAAGGAGCTG AAGATCGCCA AGTCGCTGGC CCTCATCCTC TTCCTCTTG CCCTCAGCTG GCTGCCTITG CACATCCTCA ACTGCATCAC CCTCTTCTGC CCGTCCTGCC ACAAGCCCAG CATCCTTACC TACATTGCCA TCTTCCTCAC GCACGGCAAC TCGGCCATGA ACCCCATTGT CTATGCCTC CGCATCCAGA AGTTCCGCGT CACCTTCCTT AAGATTGGA ATGACCATTT CCGCTGCCAG CCTGCACCTC CCATTGACGA GGATCTCCCA GAAGAGAGGC CTGATGACTA G -3' (FRAG. NO:_)(SEQ. ID NO: 2432) 5'-CGCAT1TGTG TTTTAATAAA AGAATCTGGA AGATAAATAG TCTTGAAGAG AGACAAAGGA AGGAAAATTT AAATCCTrAG ATTCAAGCAG AAGAATTCCA TGTGGAAGGT TTGGGTTGTT GTGTTGTTG TTTGGTGTGT =ITrGTTT TTTGT TI TGT1"TIT TGAGATGGAG TCTCGCTGTG TTACCGGGAG CGACAGAGCC GCACGGCCGA GTCGAGTCCC AGCCAGCTAC CATCCCTCTG GAGCTTACCG GCCGGCCTG GCTTCCCCAG GAATCCCTGG AGCTAGCGGC TGCTGAAGGC GTCGAGGTGT GGGGGCACTT GGACAGAACA GTCAGGCAGC CGGGAGCTCT GCCAGCTG GTGACCTTGG GTGCTTGCCT CGTGCCCCTT GGTGCCCGTC TGCTGATGTG CCCAGCCTGT GCCCGCCATG CCGCCCTCCA TCTCAGCTTT CCAGGCCGCC TACATCGGCA TCGAGGTGCT CATCGCCCTG GTCTCTGTGC CCGGGAACGT GCTGGTGATC TGGGCGGTGA AGGTGAACCA GGCGCTGCGG GATGCCACCT TCTGCTTCAT CGTGTCGCTG GCGGTGGCTG ATGTGGCCGT GGGTGCCCTG GTCATCCCCC TCGCCATCCT CATCAACATT GGGCCACAGA CCTACTTCCA CACCTGCCTC ATGGTTGCCT GTCCGGTCCT CATCCTCACC CAGAGCTCCA TCCTGGCCCT GCTGGCAATT GCTGTGGACC GCTACCTCCG GGTCAAGATC CCTCTCCGGT ACAAGATGGT GGTGACCCCC CGGAGGGCGG CGGTGGCCAT AGCCGGCTGC TGGATCCTCT CCTTCGTGGT GGGACTGACC CCTATGTTrG GCTGGAACAA TCTGAGTGCG GTGGAGCGGG CCTGGGCAGC CAACGGCAGC ATGGGGGAGC CCGTGATCAA GTGCGAGTTC WO 00/09525 PCTIUS99/17712 EPI-109 86 GAGAAGGTCA TCAGCATGGA GTACATGGTC TACTTCAACT TCTTTGTGTG GGTGCTGCCC CCGCTTCTCC TCATGGTCCT CATCTACCTG GAGGTCTTCT ACCTAATCCG CAAGCAGCTC AACAAGAAGG TGTCGGCCTC CTCCGGCGAC CCGCAGAAGT ACTATGGGAA GGAGCTGAAG ATCGCCAAGT CGCTGGCCCT CATCCTCTTC CTCTTGCCC TCAGCTGGCT GCCTTTGCAC ATCCTCAACT GCATCACCCT CTTCTGCCCG TCCTGCCACA AGCCCAGCAT CCTTACCTAC ATTGCCATCT TCCTCACGCA CGGCAACTCG GCCATGAACC CCATTGTCTA TGCCTTCCGC ATCCAGAAGT TCCGCGTCAC CTFCCTTAAG ATTTGGAATG ACCATTCCG CTGCCAGCCT GCACCTCCCA TTGACGAGGA TCTCCCAGAA GAGAGGCCTG ATGACTAGAC CCCGCCTTCC GCTCCCACCG CCCACATCCA GTGGGGTCTC AGTCCAGTCC TCACATGCCC GCTGTCCCAG GGGTCTCCCT GAGCCTGCCC CAGCTGGGCT GTTGGCTGGG GGCATGGGGG AGGCTCTGAA GAGATACCCA CAGAGTGTGG TCCCTCCACT AGGAGTTAAC TACCCTACAC CTCTGGGCCC TGCAGGAGGC CTGGGAGGGC AAGGGTCCTA CGGAGGGACC AGGTGTCTAG AGGCAACAGT GTTCTGAGCC CCCACCTGCC TGACCATCCC ATGAGCAGTC CAGAGCTrCA GGGCTGGGCA GGTCCTGGGG AGGCTGAGAC TGCAGAGGAG CCACCTGGGC TGGGAGAAGG TGCTTGGGCT TCTGCGGTGA GGCAGGGGAG TCTGCTTGTC TTAGATGTTG GTGGTGCAGC CCCAGGACCA AGCTTAAGGA GAGGAGAGCA TCTGCTCTGA GACGGATGGA AGGAGAGAGG TTGAGGATGC ACTGGCCTGT TCTGTAGGAG AGACTGGCCA GA -3' (FRAG. NO:_)(SEQ. ID NO: 2422) 5'-ATGAGTGTCA GAAGTGTGAA GGGTGCCTGT TCTGAATCCC AGAGCCTCCT CTCCCTCTGT GAGGCTGGCA GGTGAGGAAG GGTTrAACCT CACTGGAAGG AATCCCTGGA GCTAGCGGCT GCTGAAGGCG TCGAGGTGTG GGGGCACTTG GACAGAACAG TCAGGCAGCC GGGAGCTCTG CCAGCTTTGG TGACCTTGGG CCGGGCTGGG AGCGCTGCGG CGGGAGCCGG AGGACTATGA GCTGCCGCGC GTTGTCCAGA GCCCAGCCCA GCCCTACGCG CGCGGCCCGG AGCTCTGTTC CCTGGAACTT TGGGCACTGC CTCTGGGACC CCTGCCGGCC AGCAGGCAGG ATGGTGCTTG CCTCGTGCCC CTTGGTGCCC GTCTGCTGAT GTGCCCAGCC TGTGCCCGCC ATGCCGCCCT CCATCTCAGC TTTCCAGGCC GCCTACATCG GCATCGAGGT GCTCATCGCC CTGGTCTCTG TGCCCGGGAA CGTGCTGGTG ATCTGGGCGG TGAAGGTGAA CCAGGCGCTG CGGGATGCCA CCTTCTGCTT CATCGTGTCG CTGGCGGTGG CTGATGTGGC CGTGGGTGCC CTGGTCATCC CCCTCGCCAT CCTCATCAAC ATTGGGCCAC AGACCTACTT CCACACCTGC CTCATGGTTG CCTGTCCGGT CCTCATCCTC ACCCAGAGCT CCATCCTGGC CCTGCTGGCA ATTGCTGTGG ACCGCTACCT CCGGGTCAAG ATCCCTCTCC GGTACAAGAT GGTGGTGACC CCCCGGAGGG CGGCGGTGGC CATAGCCGGC TGCTGGATCC TCTCCTTCGT GGTGGGACTG ACCCCTATGT TTGGCTGGAA CAATCTGAGT GCGGTGGAGC GGGCCTGGGC AGCCAACGGC AGCATGGGGG AGCCCGTGAT CAAGTGCGAG TTCGAGAAGG TCATCAGCAT GGAGTACATG GTCTACTTCA ACTT=CTTGT GTGGGTGCTG CCCCCGCTTC TCCTCATGGT CCTCATCTAC CTGGAGGTCT TCTACCTAAT CCGCAAGCAG CTCAACAAGA AGGTGTCGGC CTCCTCCGGC GACCCGCAGA AGTACTATGG GAAGGAGCTG AAGATCGCCA AGTCGCTGGC CCTCATCCTC T7CCTCTTG CCCTCAGCTG GCTGCCTTG CACATCCTCA ACTGCATCAC CCTCTTCTGC CCGTCCTGCC ACAAGCCCAG CATCCTTACC TACATrGCCA TCTTCCTCAC GCACGGCAAC TCGGCCATGA ACCCCATTGT CTATGCCTTC CGCATCCAGA AGTTCCGCGT CACCTTCCTT AAGATTTGGA ATGACCATIT CCGCTGCCAG CCTGCACCTC CCATTGACGA GGATCTCCCA GAAGAGAGGC CTGATGACTA GACCCCGCCT TCCGCTCCCA CCAGCCCACA TCCAGTGGGG TCTCAGTCCA GTCCTCACAT GCCCGCTGTC CCAGGGGTCT CCCTGAGCCT GCCCCAGCTG GGCTGTTGGC TGGGGGCATG GGGGAGGCTC TGAAGAGATA CCCACAGAGT GTGGTCCCTC CACTAGGAGT TAACTACCCT ACACCTCTGG GCCCTGCAGG AGGCCTGGGA GGGCAAGGGT CCTACGGAGG GACCAGGTGT CTAGAGGCAA CAGTGTTCTG AGCCCCCACC TGCCTGACCA TCCCATGAGC AGTCCAGCGC TTCAGGGCTG GGCAGGTCCT GGGGAGGCTG AGACTGCAGA GGAGCCACCT GGGCTGGGAG AAGGTGCT7G GGCT7CTGCG GTGAGGCAGG GGAGTCTGCT TGTCTrAGAT GTTGGTGGTG CAGCCCCAGG ACCAAGCTTA AGGAGAGGAG AGCATCTGCT CTGAGACGGA TGGAAGGAGA GAGGTTGAGG ATGCACTGGC CTGTTCTGTA GGAGAGACTG GCCAGAGGCA GCTAAGGGGC AGGAATCAAG GAGCCTCCGT TCCCACCTCT GAGGACTCTG GACCCCAGGC CATACCAGGT GCTAGGGTGC CTGCTCTCCT TGCCCTGGGC CAGCCCAGGA TTGTACGTGG GAGAGGCAGA AAGGGTAGGT TCAGTAATCA TTTCTGATGA TTTGCTGGAG TGCTGGCTCC ACGCCCTGGG GAGTGAGCTT GGTGCGGTAG GTGCTGGCCT CAAACAGCCA CGAGGTGGTA GCTCTGAGCC CTCCTTCTTG CCCTGAGCTT TCCGGGGAGG AGCCTGGAGT GTAATTACCT GTCATCTGGG CCACCAGCTC CACTGGCCCC CGTTGCCGGG CCTGGACTGT CCTAGGTGAC CCCATCTCTG CTGCTTCTGG GCCTGATGGA GAGGAGAACA CTAGACATGC CAACTCGGGA GCATTCTGCC TGCCTGGGAA CGGGGTGGAC GAGGGAGTGT CTGTAAGGAC TCAGTGTTGA CTGTAGGCGC CCCTGGGGTG GGTTTAGCAG GCTGCAGCAG GCAGAGGAGG AGTACCCCCC TGAGAGCATG TGGGGGAAGG CCTTGCTGTC ATGTGAATCC CTCAATACCC CTAGTATCTG GCTGGGTTTT CAGGGGCTTT GGAAGCTCTG TrGCAGGTGT CCGGGGGTCT AGGACTITAG GGATCTGGGA TCTGGGGAAG GACCAACCCA TGCCCTGCCA AGCCTGGAGC CCCTGTGTTG GGGGGCAAGG TGGGGGAGCC TGGAGCCCCT GTGTGGGAGG GCGAGGCGGG GGAGCCTGGA GCCCCTGTGT GGGAGGGCGA GGCGGGGGAT CCTGGAGCCC CTGTGTCGGG GGGCGAGGGA GGGGAGGTGG CCGTCGGTTG ACCTTCTGAA CATGAGTGTC AACTCCAGGA CTTGTCCA AGCCCTCCC TCTGTUGGAA ATTGGGTGTG CCCTGGCTCC CAAGGGAGGC CCATGTGACT AATAAAAAAC TGTGAACCCT -3' (FRAG. NO:_) (SEQ. ID NO: 2421) 5'-ATGCCGCCCT CCATCTCAGC TTTCCAGGCC GCCTACATCG GCATCGAGGT GCTCATCGCC CTGGTCTCTG TGCCCGGGAA CGTGCTGGTG ATCTGGGCGG TGAAGGTGAA CCAGGCGCTG CGGGATGCCA CCTTCTGCTT CATCGTCTCG CTGGCGGTGG CTGATGTGGC CGTGGGTGCC CTGGTCATCC CCCTCGCCAT CCTCATCAAC ATTGGGCCAC AGACCTACTT CCACACCTGC CTCATGGT7G CCTGTCCGGT CCTCATCCTC ACCCAGAGCT CCATCCTGGC CCTGCTGGCA ATTGCTGTGG ACCGCTACCT CCGGGTCAAG ATCCCTCTCC GGTACAAGAT GGTGGTGACC CCCCGGAGGG CGGCGGTGGC CATAGCCGGC TGCTGGATCC TCTCCTTCGT GGTGGGACTG CCCCTATGT TTGGCTGGAA CAATCTGAGT GCGGTGGAGC GGGCCTGGGC AGCCAACGGC AGCATGGGGG AGCCCGTGAT CAAGTGCGAG TTCGAGAAGG TCATCAGCAT GGAGTACATG GTCTACTTCA ACTTCITTGT GTGGGTGCTG CCCCCGCTTC TCCTCATGGT CCTCATCTAC CTGGAGGTCT TCTACCTAAT CCGCAAGCAG CTCAACAAGA AGGTGTCGGC CTCCTCCGGC GACCCGCAGA AGTACTATGG GAAGGAGCTG AAGATCGCCA AGTCGCTGGC CCTCATCCTC TrCCTCTG CCCTCAGCTG GCTGCCTG CACATCCTCA ACTGCATCAC CCTCTTCTGC CCGTCCTGCC ACAAGCCCAG CATCCTTACC TACATTGCCA TCTCCTCAC GCACGGCAAC TCGGCCATGA ACCCCATTGT CTATGCCTTC CGCATCCAGA AGTTCCGCGT CACCTTCCT AAGATGGA ATGACCATTT CCGCTGCCAG CCTGCACCTC CCATTGACGA GGATCTCCCA GAAGAGAGGC CTGATGACTA G (FRAG NO: _) (SEQ. ID NO: 2420) 5'-GAT GGA GGG CGG CAT GGC GGG-3' (FRAG. NO: 1657) (SEQ ID NO:1670) 5'-G CGG GTC GCC GG-3' (FRAG. NO: 1658) (SEQ ID NO:1671) 5'-GGC GGG CBC BGG C-3' (FRAG. NO: 1659) (SEQ ID NO:1672) 5'-GGC GGG CBC-3' (FRAG. NO: 1660) (SEQ ID NO:1673) 5'-GC GGC CTG G-3' (FRAG. NO: 1661) (SEQ ID NO:1674) 5'-GGB GGG CGG C-3' (FRAG. NO: 1662) (SEQ ID NO:1675) WO 00/09525 PCT/US99/17712 tii-U9 87 5'-GBT GGB GGG-3' (FRAG. NO: 1663) (SEQ ID NO:1676) 5-GG CTG GGC-3' (FRAG. NO: 1664) (SEQ ID NO:1677) 5'-GC GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (FRAG.1) (SEQ. ID NO: 11) 5'-C GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (FRAG 2) (SEQ. ID NO: 12) 5'-GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (FRAG 3) (SEQ. ID NO: 13) 5'-GC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (FRAG 4) (SEQ. ID NO: 14) 5'-C CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (FRAG 5) (SEQ. ID NO: 15) 5'-CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (FRAG 6) (SEQ. ID NO: 16) 5'-TG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (FRAG 7) (SEQ. ID NO: 17) 5'-G GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (FRAG 8) (SEQ. ID NO: 18) 5'-GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (FRAG 9) (SEQ. ID NO: 19) 5'-AA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (FRAG 10) (SEQ. ID NO: 20) 5'-A AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' FRAGG 11) (SEQ. ID NO: 21) 5'-AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (FRAG 12) (SEQ. ID NO: 22) 5'-GC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (FRAG 13) (SEQ. ID NO: 23) 5'-C TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (FRAG 14) (SEQ. ID NO: 24) 5'-TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' FRAGG 15) (SEQ. ID NO: 25) 5'-GA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (FRAG 16) (SEQ. ID NO: 26) 5'-A GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' FRAGG 17) (SEQ. ID NO: 27) 5'-GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' FRAGG 18) (SEQ. ID NO: 28) 5'-AT GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (FRAG 19) (SEQ. ID NO: 29) 5'-T GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (FRAG 20) (SEQ. ID NO: 30) 5'-GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' FRAGG 21) (SEQ. ID NO: 31) 5'-GA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' FRAGG 22) (SEQ. ID NO: 32) 5'-A GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' FRAGG 23) (SEQ. ID NO: 33) 5'-GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (FRAG 24) (SEQ. ID NO: 34) 5'-GG CGG CAT GGC GGG CAC AGG CTG GGC-3' (FRAG 25) (SEQ. ID NO: 35) 5'-G CGG CAT GGC GGG CAC AGG CTG GGC-3' (FRAG 26) (SEQ. ID NO: 36) 5'-CGG CAT GGC GGG CAC AGG CTG GGC-3' FRAGG 27) (SEQ. ID NO: 37) 5'-GG CAT GGC GGG CAC AGG CTG GGC-3' (FRAG 28) (SEQ. ID NO: 38) 5'-G CAT GGC GGG CAC AGG CTG GGC-3' (FRAG 29) (SEQ. ID NO: 39) 5'-CAT GGC GGG CAC AGG CTG GGC-3' (FRAG 30) (SEQ. ID NO: 40) 5'-AT GGC GGG CAC AGG CTG GGC-3' (FRAG 31) (SEQ. ID NO: 41) 5'-T GGC GGG CAC AGG CTG GGC-3' FRAGG 32) (SEQ. ID NO: 42) 5'-GGC GGG CAC AGG CTG GGC-3' (FRAG 33) (SEQ. ID NO: 43) 5'-GC GGG CAC AGG CTG GGC-3' (FRAG 34) (SEQ. ID NO: 44) 5'-C GGG CAC AGG CTG GGC-3' (FRAG 35) (SEQ. ID NO: 45) 5'-GGG CAC AGG CTG GGC-3' FRAGG 36) (SEQ. ID NO: 46) 5'-GG CAC AGG CTG GGC-3' (FRAG 37) (SEQ. ID NO: 47) 5'-G CAC AGG CTG GGC-3' (FRAG 38) (SEQ. ID NO: 48) 5'-CAC AGG CTG GGC-3' (FRAG 39) (SEQ. ID NO: 49) 5'-AC AGG CTG GGC-3' (FRAG 40) (SEQ. ID NO: 50) 5-C AGG CTG GGC-3' FRAGG 41) (SEQ. ID NO: 51) 5 -AGG CTG GGC-3' (FRAG 42) (SEQ. ID NO: 52) 5 -GGC GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (FRAG 43) (SEQ. ID NO: 53) 5 -GGC GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GG-3' (FRAG 44) (SEQ. ID NO: 54) 5'-GGC GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG G-3' FRAGG 45) (SEQ. ID NO: 55) 5'-GGC GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG -3' FRAGG 46) (SEQ. ID NO: 56) 5'-GGC GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CT-3' (FRAG 47) (SEQ. ID NO: 57) 5'-GGC GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG C-3' FRAGG 48) (SEQ. ID NO: 58) 5'-GGC GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG -3' (FRAG 49) (SEQ. ID NO: 59) 5'-GGC GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AG-3' (FRAG 50) (SEQ. ID NO: 60) 5'-GGC GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC A-3' FRAGG 51) (SEQ. ID NO: 61) 5'-GGC GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC-3' FRAGG 52) (SEQ. ID NO: 62) 5'-GGC GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CA-3' FRAGG 53) (SEQ. ID NO: 63) 5'-GGC GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG C-3' (FRAG 54) (SEQ. ID NO: 64) 5'-GGC GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG -3' FRAGG 55) (SEQ. ID NO: 65) 5'-GGC GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GG-3' (FRAG 56) (SEQ. ID NO: 66) 5'-GGC GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC G-3'(FRAG 57) (SEQ. ID NO: 67) 5'-GGC GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC -3' FRAGG 58) (SEQ. ID NO: 68) 5'-GGC GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GG -3' FRAGG 59) (SEQ. ID NO: 69) 5'-GGC GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT G -3' (FRAG 60) (SEQ. ID NO: 70) 5'-GGC GGC CrG GAA AGC TGA GAT GGA GGG CGG CAT -3' FRAGG 61) (SEQ. ID NO: 71) 5'-GGC GGC CTG GAA AGC TGA GAT GGA GGG CGG CA-3' FRAGG 62) (SEQ. ID NO: 72) 5'-GGC GGC CTG GAA AGC TGA GAT GGA GGG CGG C-3' FRAGG 63) (SEQ. ID NO: 73) 5'-GGC GGC CTG GAA AGC TGA GAT GGA GGG CGG -3' FRAGG 64) (SEQ. ID NO: 74) 5'-GGC GGC CTG GAA AGC TGA GAT GGA GGG CG -3' (FRAG 65) (SEQ. ID NO: 75) 5'-GGC GGC CTG GAA AGC TGA GAT GGA GGG C -3' (FRAG 66) (SEQ. ID NO: 76) 5'-GGC GGC CTG GAA AGC TGA GAT GGA GGG -3' (FRAG 67) (SEQ. ID NO: 77) WO 00/09525 PCT/US99/17712 EPI-109 88 5'-GGC GGC CTG GAA AGC TGA GAT GGA GG -3' (FRAG 68) (SEQ. ID NO: 78) 5'-GGC GGC CTG GAA AGC TGA GAT GGA G -3' (FRAG 69) (SEQ. ID NO: 79) 5'-GGC GGC CTG GAA AGC TGA GAT GGA -3' (FRAG 70) (SEQ. ID NO: 80) 5'-GGC GGC CTG GAA AGC TGA GAT GG -3' (FRAG 71) (SEQ. ID NO: 81) 5'-GGC GGC CTG GAA AGC TGA GAT G -3' (FRAG 72) (SEQ. ID NO: 82) 5'-GGC GGC CTG GAA AGC TGA GAT -3' (FRAG 73) (SEQ. ID NO: 83) 5'-GGC GGC CTG GAA AGC TGA GA-3' FRAGG 74) (SEQ. ID NO: 84) 5'-GGC GGC CTG GAA AGC TGA G-3' (FRAG 75) (SEQ. ID NO: 85) 5'-GGC GGC CTG GAA AGC TGA-3' FRAGG 76) (SEQ. ID NO: 86) 5'-GGC GGC CTG GAA AGC TG-3' FRAGG 77) (SEQ. ID NO: 87) 5'-GGC GGC CTG GAA AGC T-3' FRAGG 78) (SEQ. ID NO: 88) 5'-GGC GGC CTG GAA AGC-3' (FRAG 79) (SEQ. ID NO: 89) 5'-GGC GGC CTG GAA AG-3' (FRAG 80) (SEQ. ID NO: 90) 5'-GGC GGC CTG GAA A-3' FRAGG 81) (SEQ. ID NO: 91) 5'-GGC GGC CTG GAA-3' (FRAG 82) (SEQ. ID NO: 92) 5'-GGC GGC CTG GA-3' (FRAG 83) (SEQ. ID NO: 93) 5'-GGC GGC CTG G-3' (FRAG 84) (SEQ. ID NO: 94) 5'-GC GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' FRAGG 85) (SEQ. ID NO: 95) 5'-GC GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GG-3' FRAGG 86) (SEQ. ID NO: 96) 5'-GC GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG G-3' FRAGG 87) (SEQ. ID NO: 97) 5'-GC GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG -3' (FRAG 88) (SEQ. ID NO: 98) 5'-GC GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CT-3' (FRAG 89) (SEQ. ID NO: 99) 5'-GC GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG C-3' (FRAG 90) (SEQ. ID NO: 100) 5'-GC GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG -3' FRAGG 91) (SEQ. ID NO: 101) 5'-GC GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AG-3' (FRAG 92) (SEQ. ID NO: 102) 5'-GC GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC A-3' (FRAG 93) (SEQ. ID NO: 103) 5'-GC GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC-3' FRAGG 94) (SEQ. ID NO: 104) 5'-GC GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CA-3' FRAGG 95) (SEQ. ID NO: 105) 5'-GC GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG C-3' FRAGG 96) (SEQ. ID NO: 106) 5'-GC GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG -3' FRAGG 97) (SEQ. ID NO: 107) 5'-GC GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GG-3' FRAGG 98) (SEQ. ID NO: 108) 5'-GC GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC G-3' (FRAG 99) (SEQ. ID NO: 109) 5'-GC GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC -3' FRAGG 100) (SEQ. ID NO: 110) 5'-GC GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GG -3' FRAGG 101) (SEQ. ID NO: 111) 5'-GC GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT G -3' FRAGG 102) (SEQ. ID NO: 112) 5'-GC GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT -3' FRAGG 103) (SEQ. ID NO: 113) 5'-GC GGC CTG GAA AGC TGA GAT GGA GGG CGG CA-3' FRAGG 104) (SEQ. ID NO: 114) 5'-GC GGC CTG GAA AGC TGA GAT GGA GGG CGG C-3' FRAGG 105) (SEQ. ID NO: 115) 5'-GC GGC CTG GAA AGC TGA GAT GGA GGG CGG -3' FRAGG 106) (SEQ. ID NO: 116) 5'-GC GGC CTG GAA AGC TGA GAT GGA GGG CG -3' FRAGG 107) (SEQ. ID NO: 117) 5'-GC GGC CTG GAA AGC TGA GAT GGA GGG C -3' FRAGG 108) (SEQ. ID NO: 118) 5'-GC GGC CTG GAA AGC TGA GAT GGA GGG -3' FRAGG 109) (SEQ. ID NO: 119) 5'-GC GGC CTG GAA AGC TGA GAT GGA GG -3' FRAGG 110) (SEQ. ID NO: 120) 5'-GC GGC CTG GAA AGC TGA GAT GGA G -3' FRAGG 111) (SEQ. ID NO: 121) 5'-GC GGC CTG GAA AGC TGA GAT GGA -3' FRAGG 112) (SEQ. ID NO: 122) 5'-GC GGC CTG GAA AGC TGA GAT GG -3' FRAGG 113) (SEQ. ID NO: 123) 5'-GC GGC CTG GAA AGC TGA GAT G -3' FRAGG 114) (SEQ. ID NO: 124) 5'-GC GGC CTG GAA AGC TGA GAT -3' (FRAG 115) (SEQ. ID NO: 125) 5'-GC GGC CTG GAA AGC TGA GA-3' FRAGG 116) (SEQ. ID NO: 126) 5'-GC GGC CTG GAA AGC TGA G-3' FRAGG 117) (SEQ. ID NO: 127) 5'-GC GGC CTG GAA AGC TGA-3' FRAGG 118) (SEQ. ID NO: 128) 5'-GC GGC CTG GAA AGC TG-3' FRAGG 119) (SEQ. ID NO: 129) 5'-GC GGC CTG GAA AGC T-3' FRAGG 120) (SEQ. ID NO: 130) 5'-GC GGC CTG GAA AGC-3' FRAGG 121) (SEQ. ID NO: 131) 5'-GC GGC CTG GAA AG-3' FRAGG 122) (SEQ. ID NO: 132) 5'-GC GGC CTG GAA A-3' FRAGG 123) (SEQ. ID NO: 133) 5'-GC GGC CTG GAA-3' FRAGG 124) (SEQ. ID NO: 134) 5'-GC GGC CTG GA-3' FRAGG 125) (SEQ. ID NO: 135) 5'-C GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' FRAGG 126) (SEQ. ID NO: 136) 5'-C GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CrG GG-3' FRAGG 127) (SEQ. ID NO: 137) 5'-C GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG G-3' FRAGG 128) (SEQ. ID NO: 138) 5'-C GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG -3' FRAGG 129) (SEQ. ID NO: 139) 5'-C GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CT-3' FRAGG 130) (SEQ. ID NO: 140) 5'-C GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG C-3' FRAGG 131) (SEQ. ID NO: 141) 5'-C GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG -3' FRAGG 132) (SEQ. ID NO: 142) 5'-C GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AG-3' FRAGG 133) (SEQ. ID NO: 143) 5'-C GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC A-3' FRAGG 134) (SEQ. ID NO: 144) 5'-C GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC-3' FRAGG 135) (SEQ. ID NO: 145) 5'-C GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CA-3' FRAGG 136) (SEQ. ID NO: 146) WO 00/09525 PCT/US99/17712 iel-109 89 5'-C GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG C-3' (FRAG 137) (SEQ. ID NO: 147) 5'-C GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG -3' (FRAG 138) (SEQ. ID NO: 148) 5'-C GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GG-3' (FRAG 139) (SEQ. ID NO: 149) 5'-C GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC G-3' (FRAG 140) (SEQ. ID NO: 150) 5'-C GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC -3' (FRAG 141) (SEQ. ID NO: 151) 5'-C GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GG -3' (FRAG 142) (SEQ. ID NO: 152) 5'-C GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT G -3' (FRA 143) (SEQ. ID NO: 153) 5'-C GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT -3' (FRAG 144) (SEQ. ID NO: 154) 5'-C GGC CTG GAA AGC TGA GAT GGA GGG CGG CA-3' (FRAG 145) (SEQ. ID NO: 155) 5'-C GGC CTG GAA AGC TGA GAT GGA GGG CGG C-3' (FRAG 146) (SEQ. ID NO: 156) 5'-C GGC CTG GAA AGC TGA GAT GGA GGG CGG -3' (FRAG 147) (SEQ. ID NO: 157) 5'-C GGC CTG GAA AGC TGA GAT GGA GGG CG -3' (FRAG 148) (SEQ. ID NO: 158) 5'-C GGC CTG GAA AGC TGA GAT GGA GGG C -3' (FRAG 148) (SEQ. ID NO: 159) 5'-C GGC CTG GAA AGC TGA GAT GGA GGG -3' (FRAG 150) (SEQ. ID NO: 160) 5'-C GGC CTG GAA AGC TGA GAT GGA GG -3' (FRAG 151) (SEQ. ID NO: 161) 5'-C GGC CTG GAA AGC TGA GAT GGA G -3' (FRAG 152) (SEQ. ID NO: 162) 5'-C GGC CTG GAA AGC TGA GAT GGA -3' (FRAG 153) (SEQ. ID NO: 163) 5'-C GGC CTG GAA AGC TGA GAT GG -3' (FRAG 154) (SEQ. ID NO: 164) 5'-C GGC CTG GAA AGC TGA GAT G -3' (FRAG 155) (SEQ. ID NO: 165) 5'-C GGC CTG GAA AGC TGA GAT -3' (FRAG 156) (SEQ. ID NO: 166) 5'-C GGC CTG GAA AGC TGA GA-3' FRAGG 157) (SEQ. ID NO: 167) 5'-C GGC CTG GAA AGC TGA G-3' (FRAG 158) (SEQ. ID NO: 168) 5'-C GGC CTG GAA AGC TGA-3' FRAGG 159) (SEQ. ID NO: 169) 5'-C GGC CTG GAA AGC TG-3' FRAGG 160) (SEQ. ID NO: 170) 5'-C GGC CTG GAA AGC T-3' (FRAG 161) (SEQ. ID NO: 171) 5'-C GGC CTG GAA AGC-3' (FRAG 162) (SEQ. ID NO: 172) 5'-C GGC CTG GAA AG-3' (FRAG 163) (SEQ. ID NO: 173) 5'-C GGC CTG GAA A-3' (FRAG 164) (SEQ. ID NO: 174) 5'-C GGC CTG GAA-3' (FRAG 165) (SEQ. ID NO: 175) 5'- GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (FRAG 166) (SEQ. ID NO: 176) 5'- GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GG-3' (FRAG 167) (SEQ. ID NO: 177) 5'- GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG G-3' (FRAG 168) (SEQ. ID NO: 178) 5'- GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG -3' (FRAG 169) (SEQ. ID NO: 179) 5'- GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CT-3' (FRAG 170) (SEQ. ID NO: 180) 5'- GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG C-3' (FRAG 171) (SEQ. ID NO: 181) 5'- GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG -3' (FRAG 172) (SEQ. ID NO: 182) 5'- GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AG-3' (FRAG 173) (SEQ. ID NO: 183) 5'- GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC A-3' FRAGG 174) (SEQ. ID NO: 184) 5'- GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC-3' (FRAG 175) (SEQ. ID NO: 185) 5'- GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CA-3' FRAGG 176) (SEQ. ID NO: 186) 5'- GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG C-3' (FRAG 177) (SEQ. ID NO: 187) 5'- GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG -3' FRAGG 178) (SEQ. ID NO: 188) 5'- GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GG-3' (FRAG 179) (SEQ. ID NO: 189) 5'- GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC G-3' (FRAG 180) (SEQ. ID NO: 190) 5'- GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC -3' FRAGG 181) (SEQ. ID NO: 191) 5'- GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GG -3' FRAGG 182) (SEQ. ID NO: 192) 5'- GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT G -3' (FRAG 183) (SEQ. ID NO: 193) 5'- GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT -3' (FRAG 184) (SEQ. ID NO: 194) 5'- GGC CTG GAA AGC TGA GAT GGA GGG CGG CA-3' (FRAG 185) (SEQ. ID NO: 195) 5'- GGC CTG GAA AGC TGA GAT GGA GGG CGG C-3' (FRAG 186) (SEQ. ID NO: 196) 5'- GGC CTG GAA AGC TGA GAT GGA GGG CGG -3' (FRAG 187) (SEQ. ID NO: 197) 5'- GGC CTG GAA AGC TGA GAT GGA GGG CG -3' (FRAG 188) (SEQ. ID NO: 198) 5'- GGC CTG GAA AGC TGA GAT GGA GGG C -3' (FRAG 189) (SEQ. ID NO: 199) 5'- GGC CTG GAA AGC TGA GAT GGA GGG -3' (FRAG 190) (SEQ. ID NO: 200) 5'- GGC CTG GAA AGC TGA GAT GGA GG -3' (FRAG 191) (SEQ. ID NO: 201) 5'- GGC CTG GAA AGC TGA GAT GGA G -3' (FRAG 192) (SEQ. ID NO: 202) 5'- GGC CTG GAA AGC TGA GAT GGA -3' (FRAG 193) (SEQ. ID NO: 203) 5'- GGC CTG GAA AGC TGA GAT GG -3' (FRAG 194) (SEQ. ID NO: 204) 5'- GGC CTG GAA AGC TGA GAT G -3' (FRAG 195) (SEQ. ID NO: 205) 5'- GGC CTG GAA AGC TGA GAT -3' (FRAG 196) (SEQ. ID NO: 206) 5'- GGC CTG GAA AGC TGA GA-3' (FRAG 197) (SEQ. ID NO: 207) 5'- GGC CTG GAA AGC TGA G-3' (FRAG 198) (SEQ. ID NO: 208) 5'- GGC CTG GAA AGC TGA-3' (FRAG 199) (SEQ. ID NO: 209) 5'- GGC CTG GAA AGC TG-3' FRAGG 200 (SEQ. ID NO: 210) 5'- GGC CTG GAA AGC T-3' (FRAG 201) (SEQ. ID NO: 211) 5'- GGC CTG GAA AGC-3' FRAGG 202) (SEQ. ID NO: 212) 5'- GGC CrG GAA AG-3' (FRAG 203) (SEQ. ID NO: 213) 5- GGC CTG GAA A-3' (FRAG 204) (SEQ. ID NO: 214) 5'- GC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (FRAG 205) (SEQ. ID NO: 215) WO 00/09525 PCT/US99/17712 EPI-109 90 5'- GC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GG-3' (FRAG 206) (SEQ. ID NO: 216) 5'- GC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG G-3' FRAGG 207) (SEQ. ID NO: 217) 5'- GC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG -3' FRAGG 208) (SEQ. ID NO: 218) 5'- GC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CT-3' (FRAG 209) (SEQ. ID NO: 219) 5'- GC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG C-3' FRAGG 210) (SEQ. ID NO: 220) 5'- GC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG -3' FRAGG 211) (SEQ. ID NO: 221) 5'- GC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AG-3' FRAGG 212) (SEQ. ID NO: 222) 5'- GC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC A-3' FRAGG 213) (SEQ. ID NO: 223) 5'- GC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC-3' FRAGG 214) (SEQ. ID NO: 224) 5'- GC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CA-3' FRAGG 215) (SEQ. ID NO: 225) 5'- GC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG C-3' FRAGG 216) (SEQ. ID NO: 226) 5'- GC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG -3' FRAGG 217) (SEQ. ID NO: 227) 5'- GC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GG-3' FRAGG 218) (SEQ. ID NO: 228) 5'- GC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC G-3' FRAGG 219) (SEQ. ID NO: 229) 5'- GC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC -3' FRAGG 220) (SEQ. ID NO: 230) 5'- GC CTG GAA AGC TGA GAT GGA GGG CGG CAT GG -3' FRAGG 221) (SEQ. ID NO: 231) 5'- GC CTG GAA AGC TGA GAT GGA GGG CGG CAT G -3' FRAGG 222) (SEQ. ID NO: 232) 5'- GC CTG GAA AGC TGA GAT GGA GGG CGG CAT -3' FRAGG 223) (SEQ. ID NO: 233) 5'- GC CTG GAA AGC TGA GAT GGA GGG CGG CA-3' FRAGG 224) (SEQ. ID NO: 234) 5'- GC CTG GAA AGC TGA GAT GGA GGG CGG C-3' FRAGG 225) (SEQ. ID NO: 235) 5'- GC CTG GAA AGC TGA GAT GGA GGG CGG -3' FRAGG 226) (SEQ. ID NO: 236) 5'- GC CTG GAA AGC TGA GAT GGA GGG CG -3' FRAGG 227) (SEQ. ID NO: 237) 5'- GC CTG GAA AGC TGA GAT GGA GGG C -3' FRAGG 228) (SEQ. ID NO: 238) 5'- GC CTG GAA AGC TGA GAT GGA GGG -3' FRAGG 229) (SEQ. ID NO: 239) 5'- GC CTG GAA AGC TGA GAT GGA GG -3' FRAGG 230) (SEQ. ID NO: 240) 5'- GC CTG GAA AGC TGA GAT GGA G -3' FRAGG 231) (SEQ. ID NO: 241) 5'- GC CTG GAA AGC TGA GAT GGA -3' FRAGG 232) (SEQ. ID NO: 242) 5'- GC CTG GAA AGC TGA GAT GG -3' FRAGG 233) (SEQ. ID NO: 243) 5'- GC CTG GAA AGC TGA GAT G -3' FRAGG 234) (SEQ. ID NO: 244) 5'- GC CTG GAA AGC TGA GAT -3' FRAGG 235) (SEQ. ID NO: 245) 5'- GC CTG GAA AGC TGA GA-3' FRAGG 236) (SEQ. ID NO: 246) 5'- GC CTG GAA AGC TGA G-3' FRAGG 237) (SEQ. ID NO: 247) 5'- GC CTG GAA AGC TGA-3' FRAGG 238) (SEQ. ID NO: 248) 5'- GC CTG GAA AGC TG-3' FRAGG 239) (SEQ. ID NO: 249) 5'- GC CTG GAA AGC T-3' FRAGG 240) (SEQ. ID NO: 250) 5'- GC CTG GAA AGC-3' FRAGG 241) (SEQ. ID NO: 251) 5'- GC CTG GAA AG-3' FRAGG 242) (SEQ. ID NO: 252) 5'- C CTG GAA AGC TGA GAT GG A GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' FRAGG 243) (SEQ. ID NO: 253) 5'- C CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GG-3' FRAGG 244) (SEQ. ID NO: 254) 5'- C CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG G-3' FRAGG 245) (SEQ. ID NO: 255) 5'- C CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG -3' FRAGG 246) (SEQ. ID NO: 256) 5'- C CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CT-3' FRAGG 247) (SEQ. ID NO: 257) 5'- C CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG C-3' FRAGG 248) (SEQ. ID NO: 258) 5'- C CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG -3' FRAGG 249) (SEQ. ID NO: 259) 5'- C CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AG-3' FRAGG 250) (SEQ. ID NO: 260) 5'- C CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC A-3' FRAGG 251) (SEQ. ID NO: 261) 5'- C CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC-3' FRAGG 252) (SEQ. ID NO: 262) 5'- C CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CA-3' FRAGG 253) (SEQ. ID NO: 263) 5'- C CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG C-3' FRAGG 254) (SEQ. ID NO: 264) 5'- C CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG -3' FRAGG 255) (SEQ. ID NO: 265) 5'- C CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GG-3' FRAGG 256) (SEQ. ID NO: 266) 5'- C CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC G-3' FRAGG 257) (SEQ. ID NO: 267) 5'- C CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC -3' FRAGG 258) (SEQ. ID NO: 268) 5'- C CTG GAA AGC TGA GAT GGA GGG CGG CAT GG -3' FRAGG 259) (SEQ. ID NO: 269) 5'- C CTG GAA AGC TGA GAT GGA GGG CGG CAT G -3' FRAGG 260) (SEQ. ID NO: 270) 5'- C CTG GAA AGC TGA GAT GGA GGG CGG CAT -3' FRAGG 261) (SEQ. ID NO: 271) 5'- C CTG GAA AGC TGA GAT GGA GGG CGG CA-3' FRAGG 262) (SEQ. ID NO: 272) 5'- C CTG GAA AGC TGA GAT GGA GGG CGG C-3' FRAGG 263) (SEQ. ID NO: 273) 5'- C CTG GAA AGC TGA GAT GGA GGG CGG -3' FRAGG 264) (SEQ. ID NO: 274) 5'- C CTG GAA AGC TGA GAT GGA GGG CG -3' FRAGG 265) (SEQ. ID NO: 275) 5'- C CTG GAA AGC TGA GAT GGA GGG C -3' FRAGG 266) (SEQ. ID NO: 276) 5'- C CTG GAA AGC TGA GAT GGA GGG -3' FRAGG 267) (SEQ. ID NO: 277) 5'- C CTG GAA AGC TGA GAT GGA GG -3' FRAGG 268) (SEQ. ID NO: 278) 5'- C CTG GAA AGC TGA GAT GGA G -3' FRAGG 269) (SEQ. ID NO: 279) 5'- C CTG GAA AGC TGA GAT GGA -3' FRAGG 270) (SEQ. ID NO: 280) 5'- C CrG GAA AGC TGA GAT GG -3' FRAGG 271) (SEQ. ID NO: 281) 5'- C CTG GAA AGC TGA GAT G -3' FRAGG 272) (SEQ. ID NO: 282) 5'- C CTG GAA AGC TGA GAT -3' FRAGG 273) (SEQ. ID NO: 283) 5'- C CTG GAA AGC TGA GA-3' FRAGG 274) (SEQ. ID NO: 284) WO 00/09525 PCT/US99/17712 EPI-109 91 5'- C CTG GAA AGC TGA G-3' (FRAG 275) (SEQ. ID NO: 285) 5'- C CTG GAA AGC TGA-3' (FRAG 276) (SEQ. ID NO: 286) 5'- C CTG GAA AGC TG-3' (FRAG 277) (SEQ. ID NO: 287) 5'- C CTG GAA AGC T-3' (FRAG 278) (SEQ. ID NO: 288) 5'- C CTG GAA AGC-3' (FRAG 279) (SEQ. ID NO: 289) 5'- CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (FRAG 280) (SEQ. ID NO: 290) 5'- CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GG-3' (FRAG 281) (SEQ. ID NO: 291) 5'- CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG G-3' (FRAG 282) (SEQ. ID NO: 292) 5'- CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG -3' (FRAG 283) (SEQ. ID NO: 293) 5'- CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CT-3' (FRAG 284) (SEQ. ID NO: 294) 5'- CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG C-3' (FRAG 285) (SEQ. ID NO: 295) 5'- CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG -3' (FRAG 286) (SEQ. ID NO: 296) 5'- CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AG-3' (FRAG 287) (SEQ. ID NO: 297) 5'- CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC A-3' (FRAG 288) (SEQ. ID NO: 298) 5'- CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC-3' (FRAG 289) (SEQ. ID NO: 299) 5'- CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CA-3' (FRAG 290) (SEQ. ID NO: 300) 5'- CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG C-3' (FRAG 291) (SEQ. ID NO: 301) 5'- CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG -3' (FRAG 292) (SEQ. ID NO: 302) 5'- CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GG-3' FRAGG 293) (SEQ. ID NO: 303) 5'- CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC G-3' (FRAG 294) (SEQ. ID NO: 304) 5'- CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC -3' (FRAG 295) (SEQ. ID NO: 305) 5'- CTG GAA AGC TGA GAT GGA GGG CGG CAT GG -3' (FRAG 296) (SEQ. ID NO: 306) 5'- CTG GAA AGC TGA GAT GGA GGG CGG CAT G -3' (FRAG 297) (SEQ. ID NO: 307) 5'- CTG GAA AGC TGA GAT GGA GGG CGG CAT -3' (FRAG 298) (SEQ. ID NO: 308) 5'- CTG GAA AGC TGA GAT GGA GGG CGG CA-3' (FRAG 299) (SEQ. ID NO: 309) 5'- CTG GAA AGC TGA GAT GGA GGG CGG C-3' (FRAG 300) (SEQ. ID NO: 310) 5'- CTG GAA AGC TGA GAT GGA GGG CGG -3' (FRAG 301) (SEQ. ID NO: 311) 5'- CTG GAA AGC TGA GAT GGA GGG CG -3' (FRAG 302) (SEQ. ID NO: 312) 5'- CTG GAA AGC TGA GAT GGA GGG C -3' (FRAG 303) (SEQ. ID NO: 313) 5'- CTG GAA AGC TGA GAT GGA GGG -3' (FRAG 304) (SEQ. ID NO: 314) 5'- CTG GAA AGC TGA GAT GGA GG -3' (FRAG 305) (SEQ. ID NO: 315) 5'- CTG GAA AGC TGA GAT GGA G -3' (FRAG 306) (SEQ. ID NO: 316) 5'- CTG GAA AGC TGA GAT GGA -3' (FRAG 307) (SEQ. ID NO: 317) 5'- CTG GAA AGC TGA GAT GG -3' (FRAG 308) (SEQ. ID NO: 318) 5'- CTG GAA AGC TGA GAT G -3' (FRAG 309) (SEQ. ID NO: 319) 5'- CTG GAA AGC TGA GAT -3' (FRAG 310) (SEQ. ID NO: 320) 5'- CTG GAA AGC TGA GA-3' (FRAG 311) (SEQ. ID NO: 321) 5'- CTG GAA AGC TGA G-3' FRAGG 312) (SEQ. ID NO: 322) 5'- CTG GAA AGC TGA-3' (FRAG 313) (SEQ. ID NO: 323) 5'- CTG GAA AGC TG-3' (FRAG 314) (SEQ. ID NO: 324) 5'- CTG GAA AGC T-3' (FRAG 315) (SEQ. ID NO: 325) 5'- TG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' FRAGG 316) (SEQ. ID NO: 326) 5'- TG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GG-3' (FRAG 317) (SEQ. ID NO: 327) 5'- TG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG G-3' FRAGG 318) (SEQ. ID NO: 328) 5'- TG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG -3' (FRAG 319) (SEQ. ID NO: 329) 5'- TG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CT-3' (FRAG 320) (SEQ. ID NO: 330) 5'- TG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG C-3' (FRAG 321) (SEQ. ID NO: 331) 5'- TG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG -3' (FRAG 322) (SEQ. ID NO: 332) 5'- TG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AG-3' (FRAG 323) (SEQ. ID NO: 333) 5'- TG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC A-3' (FRAG 324) (SEQ. ID NO: 334) 5'- TG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC-3' (FRAG 325) (SEQ. ID NO: 335) 5'- TG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CA-3' (FRAG 326) (SEQ. ID NO: 336) 5'- TG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG C-3' (FRAG 327) (SEQ. ID NO: 337) 5'- TG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG -3' (FRAG 328) (SEQ. ID NO: 338) 5'- TG GAA AGC TGA GAT GGA GGG CGG CAT GGC GG-3' (FRAG 329) (SEQ. ID NO: 339) 5'- TG GAA AGC TGA GAT GGA GGG CGG CAT GGC G-3' (FRAG 330) (SEQ. ID NO: 340) 5'- TG GAA AGC TGA GAT GGA GGG CGG CAT GGC -3' (FRAG 331) (SEQ. ID NO: 341) 5'- TG GAA AGC TGA GAT GGA GGG CGG CAT GG -3' (FRAG 332) (SEQ. ID NO: 342) 5'- TG GAA AGC TGA GAT GGA GGG CGG CAT G -3' (FRAG 333) (SEQ. ID NO: 343) 5'- TG GAA AGC TGA GAT GGA GGG CGG CAT -3' FRAGG 334) (SEQ. ID NO: 344) 5'- TG GAA AGC TGA GAT GGA GGG CGG CA-3' (FRAG 335) (SEQ. ID NO: 345) 5'- TG GAA AGC TGA GAT GGA GGG CGG C-3' (FRAG 336) (SEQ. ID NO: 346) 5'- TG GAA AGC TGA GAT GGA GGG CGG -3' (FRAG 337) (SEQ. ID NO: 347) 5'- TG GAA AGC TGA GAT GGA GGG CG -3' (FRAG 338) (SEQ. ID NO: 348) 5'- TG GAA AGC TGA GAT GGA GGG C -3' FRAGG 339) (SEQ. ID NO: 349) 5'- TG GAA AGC TGA GAT GGA GGG -3' FRAGG 340) (SEQ. ID NO: 350) 5'- TG GAA AGC TGA GAT GGA GG -3' (FRAG 341) (SEQ. ID NO: 351) 5'- TG GAA AGC TGA GAT GGA G -3' (FRAG 342) (SEQ. ID NO: 352) 5'- TG GAA AGC TGA GAT GGA -3' (FRAG 343) (SEQ. ID NO: 353) WO 00/09525 PCT/US99/17712 EPI-109 92 5'- TG GAA AGC TGA GAT GG -3' (FRAG 344) (SEQ. ID NO: 354) 5'- TG GAA AGC TGA GAT G -3' (FRAG 345) (SEQ. ID NO: 355) 5'- TG GAA AGC TGA GAT -3' (FRAG 346) (SEQ. ID NO: 356) 5'- TG GAA AGC TGA GA-3' (FRAG 347) (SEQ. ID NO: 357) 5'- TG GAA AGC TGA G-3' FRAGG 348) (SEQ. ID NO: 358) 5'- TG GAA AGC TGA-3' FRAGG 349) (SEQ. ID NO: 359) 5'- TG GAA AGC TG-3' (FRAG 350) (SEQ. ID NO: 360) 5'- G GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' FRAGG 351) (SEQ. ID NO: 361) 5'- G GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GG-3' (FRAG 352) (SEQ. ID NO: 362) 5'- G GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG G-3' FRAGG 353) (SEQ. ID NO: 363) 5'- G GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG -3' (FRAG 354) (SEQ. ID NO: 364) 5'- G GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CT-3' (FRAG 355) (SEQ. ID NO: 365) 5'- G GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG C-3' (FRAG 356) (SEQ. ID NO: 366) 5'- G GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG -3' (FRAG 357) (SEQ. ID NO: 367) 5'- G GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AG-3' FRAGG 358) (SEQ. ID NO: 368) 5'- G GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC A-3' (FRAG 359) (SEQ. ID NO: 369) 5'- G GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC-3' FRAGG 360) (SEQ. ID NO: 370) 5'- G GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CA-3' (FRAG 361) (SEQ. ID NO: 371) 5'- G GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG C-3' (FRAG 362) (SEQ. ID NO: 372) 5'- G GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG -3' (FRAG 363) (SEQ. ID NO: 373) 5'- G GAA AGC TGA GAT GGA GGG CGG CAT GGC GG-3' (FRAG 364) (SEQ. ID NO: 374) 5'- G GAA AGC TGA GAT GGA GGG CGG CAT GGC G-3' FRAGG 365) (SEQ. ID NO: 375) 5'- G GAA AGC TGA GAT GGA GGG CGG CAT GGC -3' FRAGG 366) (SEQ. ID NO: 376) 5'- G GAA AGC TGA GAT GGA GGG CGG CAT GG -3' (FRAG 367) (SEQ. ID NO: 377) 5'- G GAA AGC TGA GAT GGA GGG CGG CAT G -3' (FRAG 368) (SEQ. ID NO: 378) 5'- G GAA AGC TGA GAT GGA GGG CGG CAT -3' FRAGG 369) (SEQ. ID NO: 379) 5'- G GAA AGC TGA GAT GGA GGG CGG CA-3' FRAGG 370) (SEQ. ID NO: 380) 5'- G GAA AGC TGA GAT GGA GGG CGG C-3' FRAGG 371) (SEQ. ID NO: 381) 5'- G GAA AGC TGA GAT GGA GGG CGG -3' FRAGG 372) (SEQ. ID NO: 382) 5'- G GAA AGC TGA GAT GGA GGG CG -3' FRAGG 373) (SEQ. ID NO: 383) 5'- G GAA AGC TGA GAT GGA GGG C -3' FRAGG 374) (SEQ. ID NO: 384) 5'- G GAA AGC TGA GAT GGA GGG -3' FRAGG 375) (SEQ. ID NO: 385) 5'- G GAA AGC TGA GAT GGA GG -3' (FRAG 376) (SEQ. ID NO: 386) 5'- G GAA AGC TGA GAT GGA G -3' (FRAG 377) (SEQ. ID NO: 387) 5'- G GAA AGC TGA GAT GGA -3' (FRAG 378) (SEQ. ID NO: 388) 5'- G GAA AGC TGA GAT GG -3' FRAGG 379) (SEQ. ID NO: 389) 5'- G GAA AGC TGA GAT G -3' (FRAG 380) (SEQ. ID NO: 390) 5'- G GAA AGC TGA GAT -3' (FRAG 381) (SEQ. ID NO: 391) 5'- G GAA AGC TGA GA-3' (FRAG 382) (SEQ. ID NO: 392) 5'- G GAA AGC TGA G-3' FRAGG 383) (SEQ. ID NO: 393) 5'- G GAA AGC TGA-3' (FRAG 384) (SEQ. ID NO: 394) 5'- GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (FRAG 385) (SEQ. ID NO: 395) 5'- GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GG-3' FRAGG 386) (SEQ. ID NO: 396) 5'- GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG G-3' FRAGG 387) (SEQ. ID NO: 397) 5'- GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG -3' FRAGG 388) (SEQ. ID NO: 398) 5'- GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CT-3' FRAGG 389) (SEQ. ID NO: 399) 5'- GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG C-3' FRAGG 390) (SEQ. ID NO: 400) 5'- GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG -3' (FRAG 391) (SEQ. ID NO: 401) 5'- GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AG-3' (FRAG 392) (SEQ. ID NO: 402) 5'- GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC A-3' FRAGG 393) (SEQ. ID NO: 403) 5'- GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC-3' FRAGG 394) (SEQ. ID NO: 404) 5'- GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CA-3' (FRAG 395) (SEQ. ID NO: 405) 5'- GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG C-3' FRAGG 396) (SEQ. ID NO: 406) 5'- GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG -3' FRAGG 397) (SEQ. ID NO: 407) 5'- GAA AGC TGA GAT GGA GGG CGG CAT GGC GG-3' (FRAG 398) (SEQ. ID NO: 408) 5'- GAA AGC TGA GAT GGA GGG CGG CAT GGC G-3' (FRAG 399) (SEQ. ID NO: 409) 5'- GAA AGC TGA GAT GGA GGG CGG CAT GGC -3' (FRAG 400) (SEQ. ID NO: 410) 5'- GAA AGC TGA GAT GGA GGG CGG CAT GG -3' (FRAG 401) (SEQ. ID NO: 411) 5'- GAA AGC TGA GAT GGA GGG CGG CAT G -3' FRAGG 402) (SEQ. ID NO: 412) 5'- GAA AGC TGA GAT GGA GGG CGG CAT -3' (FRAG 403) (SEQ. ID NO: 413) 5'- GAA AGC TGA GAT GGA GGG CGG CA-3' FRAGG 404) (SEQ. ID NO: 414) 5'- GAA AGC TGA GAT GGA GGG CGG C-3' (FRAG 405) (SEQ. ID NO: 415) 5'- GAA AGC TGA GAT GGA GGG CGG -3' (FRAG 406) (SEQ. ID NO: 416) 5'- GAA AGC TGA GAT GGA GGG CG -3' (FRAG 407) (SEQ. ID NO: 417) 5'- GAA AGC TGA GAT GGA GGG C -3' (FRAG 408) (SEQ. ID NO: 418) 5'- GAA AGC TGA GAT GGA GGG -3' FRAGG 409) (SEQ. ID NO: 419) 5'- GAA AGC TGA GAT GGA GG -3' (FRAG 410) (SEQ. ID NO: 420) 5'- GAA AGC TGA GAT GGA G -3' FRAGG 411) (SEQ. ID NO: 421) 5'- GAA AGC TGA GAT GGA -3' (FRAG 412) (SEQ. ID NO: 422) WO 00/09525 PCT/US99/17712 EPI-109 93 5'- GAA AGC TGA GAT GG -3' (FRAG 413) (SEQ. ID NO: 423) 5'- GAA AGC TGA GAT G -3' (FRAG 414) (SEQ. ID NO: 424) 5'- GAA AGC TGA GAT -3' (FRAG 415) (SEQ. ID NO: 425) 5'- GAA AGC TGA GA-3' (FRAG 416) (SEQ. ID NO: 426) 5'- GAA AGC TGA G-3' (FRAG 417) (SEQ. ID NO: 427) 5'- AA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (FRAG 418) (SEQ. ID NO: 428) 5'- AA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GG-3' (FRAG 419) (SEQ. ID NO: 429) 5'- AA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG G-3' (FRAG 420) (SEQ. ID NO: 430) 5'- AA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG -3' (FRAG 421) (SEQ. ID NO: 431) 5'- AA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CT-3' (FRAG 422) (SEQ. ID NO: 432) 5'- AA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG C-3' (FRAG 423) (SEQ. ID NO: 433) 5'- AA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG -3'(FRAG 424) (SEQ. ID NO: 434) 5'- AA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AG-3' (FRAG 425) (SEQ. ID NO: 435) 5'- AA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC A-3' (FRAG 426) (SEQ. ID NO: 436) 5'- AA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC-3' (FRAG 427) (SEQ. ID NO: 437) 5'- AA AGC TGA GAT GGA GGG CGG CAT GGC GGG CA-3' (FRAG 428) (SEQ. ID NO: 438) 5'- AA AGC TGA GAT GGA GGG CGG CAT GGC GGG C-3' (FRAG 429) (SEQ. ID NO: 439) 5'- AA AGC TGA GAT GGA GGG CGG CAT GGC GGG -3' (FRAG 430) (SEQ. ID NO: 440) 5'- AA AGC TGA GAT GGA GGG CGG CAT GGC GG-3' (FRAG 431) (SEQ. ID NO: 441) 5'- AA AGC TGA GAT GGA GGG CGG CAT GGC G-3' (FRAG 432) (SEQ. ID NO: 442) 5'- AA AGC TGA GAT GGA GGG CGG CAT GGC -3' (FRAG 433) (SEQ. ID NO: 443) 5'- AA AGC TGA GAT GGA GGG CGG CAT GG -3' (FRAG 434) (SEQ. ID NO: 444) 5'- AA AGC TGA GAT GGA GGG CGG CAT G -3' FRAGG 435) (SEQ. ID NO: 445) 5'- AA AGC TGA GAT GGA GGG CGG CAT -3' (FRAG 436) (SEQ. ID NO: 446) 5'- AA AGC TGA GAT GGA GGG CGG CA-3' (FRAG 437) (SEQ. ID NO: 447) 5'- AA AGC TGA GAT GGA GGG CGG C-3' (FRAG 438) (SEQ. ID NO: 448) 5'- AA AGC TGA GAT GGA GGG CGG -3' (FRAG 439) (SEQ. ID NO: 449) 5'- AA AGC TGA GAT GGA GGG CG -3' (FRAG 440) (SEQ. ID NO: 450) 5'- AA AGC TGA GAT GGA GGG C -3' (FRAG 441) (SEQ. ID NO: 451) 5'- AA AGC TGA GAT GGA GGG -3' (FRAG 442) (SEQ. ID NO: 452) 5'- AA AGC TGA GAT GGA GG -3' (FRAG 443) (SEQ. ID NO: 453) 5'- AA AGC TGA GAT GGA G -3' (FRAG 444) (SEQ. ID NO: 454) 5'- AA AGC TGA GAT GGA -3' (FRAG 445) (SEQ. ID NO: 455) 5'- AA AGC TGA GAT GG -3' (FRAG 446) (SEQ. ID NO: 456) 5'- AA AGC TGA GAT G -3' (FRAG 447) (SEQ. ID NO: 457) 5'- AA AGC TGA GAT -3' (FRAG 448) (SEQ. ID NO: 458) 5'- AA AGC TGA GA-3' (FRAG 449) (SEQ. ID NO: 459) 5'- A AGC TGA GAT GGA GGG CG G CAT GGC GGG CAC AGG CTG GGC-3' (FRAG 450) (SEQ. ID NO: 460) 5'- A AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GG-3' (FRAG 451) (SEQ. ID NO: 461) 5'- A AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG G-3' (FRAG 452) (SEQ. ID NO: 462) 5'- A AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG -3' (FRAG 453) (SEQ. ID NO: 463) 5'- A AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CT-3' (FRAG 454) (SEQ. ID NO: 464) 5'- A AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG C-3' (FRAG 455) (SEQ. ID NO: 465) 5'- A AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG -3' FRAGG 456) (SEQ. ID NO: 466) 5'- A AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AG-3' (FRAG 457) (SEQ. ID NO: 467) 5'- A AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC A-3' (FRAG 458) (SEQ. ID NO: 468) 5'- A AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC-3' (FRAG 459) (SEQ. ID NO: 469) 5'- A AGC TGA GAT GGA GGG CGG CAT GGC GGG CA-3' (FRAG 460) (SEQ. ID NO: 470) 5'- A AGC TGA GAT GGA GGG CGG CAT GGC GGG C-3' (FRAG 461) (SEQ. ID NO: 471) 5'- A AGC TGA GAT GGA GGG CGG CAT GGC GGG -3' (FRAG 462) (SEQ. ID NO: 472) 5'- A AGC TGA GAT GGA GGG CGG CAT GGC GG-3' (FRAG 463) (SEQ. ID NO: 473) 5'- A AGC TGA GAT GGA GGG CGG CAT GGC G-3' (FRAG 464) (SEQ. ID NO: 474) 5'- A AGC TGA GAT GGA GGG CGG CAT GGC -3' (FRAG 465) (SEQ. ID NO: 475) 5'- A AGC TGA GAT GGA GGG CGG CAT GG -3' (FRAG 466) (SEQ. ID NO: 476) 5'- A AGC TGA GAT GGA GGG CGG CAT G -3' FRAGG 467) (SEQ. ID NO: 477) 5'- A AGC TGA GAT GGA GGG CGG CAT -3' (FRAG 468) (SEQ. ID NO: 478) 5'- A AGC TGA GAT GGA GGG CGG CA-3' (FRAG 469) (SEQ. ID NO: 479) 5'- A AGC TGA GAT GGA GGG CGG C-3' (FRAG 470) (SEQ. ID NO: 480) 5'- A AGC TGA GAT GGA GGG CGG -3' (FRAG 471) (SEQ. ID NO: 481) 5'- A AGC TGA GAT GGA GGG CG -3' (FRAG 472) (SEQ. ID NO: 482) 5'- A AGC TGA GAT GGA GGG C -3' (FRAG 473) (SEQ. ID NO: 483) 5'- A AGC TGA GAT GGA GGG -3' (FRAG 474) (SEQ. ID NO: 484) 5'- A AGC TGA GAT GGA GG -3' (FRAG 475) (SEQ. ID NO: 485) 5'- A AGC TGA GAT GGA G -3' (FRAG 476) (SEQ. ID NO: 486) 5'- A AGC TGA GAT GGA -3' (FRAG 477) (SEQ. ID NO: 487) 5'- A AGC TGA GAT GG -3' (FRAG 478) (SEQ. ID NO: 488) 5'- A AGC TGA GAT G -3' (FRAG 479) (SEQ. ID NO: 489) 5'- A AGC TGA GAT -3' (FRAG 480) (SEQ. ID NO: 490) 5'- AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (FRAG 481) (SEQ. ID NO: 491) WO 00/09525 PCTIUS99/17712 EPI-109 94 5'- AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GG-3' (FRAG 482) (SEQ. ID NO: 492) 5'- AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG G-3' (FRAG 483) (SEQ. ID NO: 493) 5'- AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG -3' (FRAG 484) (SEQ. ID NO: 494) 5'- AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CT-3' (FRAG 485) (SEQ. ID NO: 495) 5'- AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG C-3' (FRAG 486) (SEQ. ID NO: 496) 5'- AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG -3' (FRAG 487) (SEQ. ID NO: 497) 5'- AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AG-3' (FRAG 488) (SEQ. ID NO: 498) 5'- AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC A-3' (FRAG 489) (SEQ. ID NO: 499) 5'- AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC-3' (FRAG 490) (SEQ. ID NO: 500) 5'- AGC TGA GAT GGA GGG CGG CAT GGC GGG CA-3' (FRAG 491) (SEQ. ID NO: 501) 5'- AGC TGA GAT GGA GGG CGG CAT GGC GGG C-3' (FRAG 492) (SEQ. ID NO: 502) 5'- AGC TGA GAT GGA GGG CGG CAT GGC GGG -3' (FRAG 493) (SEQ. ID NO: 503) 5'- AGC TGA GAT GGA GGG CGG CAT GGC GG-3' (FRAG 494) (SEQ. ID NO: 504) 5'- AGC TGA GAT GGA GGG CGG CAT GGC G-3' (FRAG 495) (SEQ. ID NO: 505) 5'- AGC TGA GAT GGA GGG CGG CAT GGC -3' (FRAG 496) (SEQ. ID NO: 506) 5'- AGC TGA GAT GGA GGG CGG CAT GG -3' (FRAG 497) (SEQ. ID NO: 507) 5'- AGC TGA GAT GGA GGG CGG CAT G -3' (FRAG 498) (SEQ. ID NO: 508) 5'- AGC TGA GAT GGA GGG CGG CAT -3' (FRAG 499) (SEQ. ID NO: 509) 5'- AGC TGA GAT GGA GGG CGG CA-3' (FRAG 500) (SEQ. ID NO: 510) 5'- AGC TGA GAT GGA GGG CGG C-3' (FRAG 501) (SEQ. ID NO: 511) 5'- AGC TGA GAT GGA GGG CGG -3' (FRAG 502) (SEQ. ID NO: 512) 5'- AGC TGA GAT GGA GGG CG -3' (FRAG 503) (SEQ. ID NO: 513) 5'- AGC TGA GAT GGA GGG C -3' (FRAG 504) (SEQ. ID NO: 514) 5'- AGC TGA GAT GGA GGG -3' (FRAG 505) (SEQ. ID NO: 515) 5'- AGC TGA GAT GGA GG -3' FRAGG 506) (SEQ. ID NO: 516) 5'- AGC TGA GAT GGA G -3' (FRAG 507) (SEQ. ID NO: 517) 5'- AGC TGA GAT GGA -3' (FRAG 508) (SEQ. ID NO: 518) 5'- AGC TGA GAT GG -3' (FRAG 509) (SEQ. ID NO: 519) 5'- AGC TGA GAT G -3' (FRAG 510) (SEQ. ID NO: 520) 5'- GC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' FRAGG 511) (SEQ. ID NO: 521) 5'- GC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GG-3' (FRAG 512) (SEQ. ID NO: 522) 5'- GC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG G-3' FRAGG 513) (SEQ. ID NO: 523) 5'- GC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG -3' (FRAG 514) (SEQ. ID NO: 524) 5'- GC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CT-3' FRAGG 515) (SEQ. ID NO: 525) 5'- GC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG C-3' (FRAG 516) (SEQ. ID NO: 526) 5'- GC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG -3' FRAGG 517) (SEQ. ID NO: 527) 5'- GC TGA GAT GGA GGG CGG CAT GGC GGG CAC AG-3' (FRAG 518) (SEQ. ID NO: 528) 5'- GC TGA GAT GGA GGG CGG CAT GGC GGG CAC A-3' FRAGG 519) (SEQ. ID NO: 529) 5'- GC TGA GAT GGA GGG CGG CAT GGC GGG CAC-3' FRAGG 520) (SEQ. ID NO: 530) 5'- GC TGA GAT GGA GGG CGG CAT GGC GGG CA-3' (FRAG 521) (SEQ. ID NO: 531) 5'- GC TGA GAT GGA GGG CGG CAT GGC GGG C-3' (FRAG 522) (SEQ. ID NO: 532) 5'- GC TGA GAT GGA GGG CGG CAT GGC GGG -3' FRAGG 523) (SEQ. ID NO: 533) 5'- GC TGA GAT GGA GGG CGG CAT GGC GG-3' FRAGG 524) (SEQ. ID NO: 534) 5'- GC TGA GAT GGA GGG CGG CAT GGC G-3' (FRAG 525) (SEQ. ID NO: 535) 5'- GC TGA GAT GGA GGG CGG CAT GGC -3' (FRAG 526) (SEQ. ID NO: 536) 5'- GC TGA GAT GGA GGG CGG CAT GG -3' FRAGG 527) (SEQ. ID NO: 537) 5'- GC TGA GAT GGA GGG CGG CAT G -3' (FRAG 528) (SEQ. ID NO: 538) 5'- GC TGA GAT GGA GGG CGG CAT -3' (FRAG 529) (SEQ. ID NO: 539) 5'- GC TGA GAT GGA GGG CGG CA-3' (FRAG 530) (SEQ. ID NO: 540) 5'- GC TGA GAT GGA GGG CGG C-3' FRAGG 531) (SEQ. ID NO: 541) 5'- GC TGA GAT GGA GGG CGG -3' FRAGG 532) (SEQ. ID NO: 542) 5'- GC TGA GAT GGA GGG CG -3' (FRAG 533) (SEQ. ID NO: 543) 5'- GC TGA GAT GGA GGG C -3' FRAGG 534) (SEQ. ID NO: 544) 5'- GC TGA GAT GGA GGG -3' FRAGG 535) (SEQ. ID NO: 545) 5'- GC TGA GAT GGA GG -3' (FRAG 536) (SEQ. ID NO: 546) 5'- GC TGA GAT GGA G -3' (FRAG 537) (SEQ. ID NO: 547) 5'- GC TGA GAT GGA -3' (FRAG 538) (SEQ. ID NO: 548) 5'- GC TGA GAT GG -3' (FRAG 539) (SEQ. ID NO: 549) 5'- C TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (FRAG 540) (SEQ. ID NO: 550) 5'- C TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GG-3' FRAGG 541) (SEQ. ID NO: 551) 5'- C TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG G-3' (FRAG 542) (SEQ. ID NO: 552) 5'- C TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG -3' (FRAG 543) (SEQ. ID NO: 553) 5'- C TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CT-3' (FRAG 544) (SEQ. ID NO: 554) 5'- C TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG C-3' (FRAG 545) (SEQ. ID NO: 555) 5'- C TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG -3' (FRAG 546) (SEQ. ID NO: 556) 5'- C TGA GAT GGA GGG CGG CAT GGC GGG CAC AG-3' (FRAG 547) (SEQ. ID NO: 557) 5'- C TGA GAT GGA GGG CGG CAT GGC GGG CAC A-3' (FRAG 548) (SEQ. ID NO: 558) 5'- C TGA GAT GGA GGG CGG CAT GGC GGG CAC-3' FRAGG 549) (SEQ. ID NO: 559) 5'- C TGA GAT GGA GGG CGG CAT GGC GGG CA-3' (FRAG 550) (SEQ. ID NO: 560) WO 00/09525 PCT/US99/17712 EPI-109 95 5*- C TGA GAT GGA GGG CGG CAT GGC GGG C-3' (FRAG 551) (SEQ. ID NO: 561) 5'- C TGA GAT GGA GGG CGG CAT GGC GGG -3' FRAGG 552) (SEQ. ID NO: 562) 5'- C TGA GAT GGA GGG CGG CAT GGC GG-3' (FRAG 553) (SEQ. ID NO: 563) 5'- C TGA GAT GGA GGG CGG CAT GGC G-3' (FRAG 554) (SEQ. ID NO: 564) 5'- C TGA GAT GGA GGG CGG CAT GGC -3' (FRAG 555) (SEQ. ID NO: 565) 5'- C TGA GAT GGA GGG CGG CAT GG -3' (FRAG 556) (SEQ. ID NO: 566) 5'- C TGA GAT GGA GGG CGG CAT G -3' (FRAG 557) (SEQ. ID NO: 567) 5'- C TGA GAT GGA GGG CGG CAT -3' (FRAG 558) (SEQ. ID NO: 568) 5'- C TGA GAT GGA GGG CGG CA-3' (FRAG 559) (SEQ. ID NO: 569) 5'- C TGA GAT GGA GGG CGG C-3' (FRAG 560) (SEQ. ID NO: 570) 5'- C TGA GAT GGA GGG CGG -3' (FRAG 561) (SEQ. ID NO: 571) 5'- C TGA GAT GGA GGG CG -3' (FRAG 562) (SEQ. ID NO: 572) 5'- C TGA GAT GGA GGG C -3' (FRAG 563) (SEQ. ID NO: 573) 5'- C TGA GAT GGA GGG -3' (FRAG 564) (SEQ. ID NO: 574) 5'- C TGA GAT GGA GG -3' (FRAG 565) (SEQ. ID NO: 575) 5'- C TGA GAT GGA G -3' (FRAG 566) (SEQ. ID NO: 576) 5'- C TGA GAT GGA -3' FRAGG 567) (SEQ. ID NO: 577) 5'- TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' FRAGG 568) (SEQ. ID NO: 578) 5'- TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GG-3' FRAGG 569) (SEQ. ID NO: 579) 5'- TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG G-3' FRAGG 570) (SEQ. ID NO: 580) 5'- TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG -3' FRAGG 571) (SEQ. ID NO: 581) 5'- TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CT-3' (FRAG 572) (SEQ. ID NO: 582) 5'- TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG C-3' (FRAG 573) (SEQ. ID NO: 583) 5'- TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG -3' (FRAG 574) (SEQ. ID NO: 584) 5'- TGA GAT GGA GGG CGG CAT GGC GGG CAC AG-3' FRAGG 575) (SEQ. ID NO: 585) 5'- TGA GAT GGA GGG CGG CAT GGC GGG CAC A-3' (FRAG 576) (SEQ. ID NO: 586) 5'- TGA GAT GGA GGG CGG CAT GGC GGG CAC-3' FRAGG 577) (SEQ. ID NO: 587) 5'- TGA GAT GGA GGG CGG CAT GGC GGG CA-3' (FRAG 578) (SEQ. ID NO: 588) 5'- TGA GAT GGA GGG CGG CAT GGC GGG C-3' FRAGG 579) (SEQ. ID NO: 589) 5'- TGA GAT GGA GGG CGG CAT GGC GGG -3' (FRAG 580) (SEQ. ID NO: 590) 5'- TGA GAT GGA GGG CGG CAT GGC GG-3' FRAGG 581) (SEQ. ID NO: 591) 5'- TGA GAT GGA GGG CGG CAT GGC G-3' FRAGG 582) (SEQ. ID NO: 592) 5'- TGA GAT GGA GGG CGG CAT GGC -3' FRAGG 583) (SEQ. ID NO: 593) 5'- TGA GAT GGA GGG CGG CAT GG -3' FRAGG 584) (SEQ. ID NO: 594) 5'- TGA GAT GGA GGG CGG CAT G -3' FRAGG 585) (SEQ. ID NO: 595) 5'- TGA GAT GGA GGG CGG CAT -3' (FRAG 586) (SEQ. ID NO: 596) 5'- TGA GAT GGA GGG CGG CA-3' (FRAG 587) (SEQ. ID NO: 597) 5'- TGA GAT GGA GGG CGG C-3' FRAGG 588) (SEQ. ID NO: 598) 5'- TGA GAT GGA GGG CGG -3' FRAGG 589) (SEQ. ID NO: 599) 5'- TGA GAT GGA GGG CG -3' (FRAG 590) (SEQ. ID NO: 600) 5'- TGA GAT GGA GGG C -3' FRAGG 591) (SEQ. ID NO: 601) 5'- TGA GAT GGA GGG -3' FRAGG 592) (SEQ. ID NO: 602) 5'- TGA GAT GGA GG -3' FRAGG 593) (SEQ. ID NO: 603) 5'- TGA GAT GGA G -3' (FRAG 594) (SEQ. ID NO: 604) 5'- GA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' FRAGG 595) (SEQ. ID NO: 605) 5'- GA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GG-3' (FRAG 596) (SEQ. ID NO: 606) 5'- GA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG G-3' (FRAG 597) (SEQ. ID NO: 607) 5'- GA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG -3' (FRAG 598) (SEQ. ID NO: 608) 5'- GA GAT GGA GGG CGG CAT GGC GGG CAC AGG CT-3' (FRAG 599) (SEQ. ID NO: 609) 5'- GA GAT GGA GGG CGG CAT GGC GGG CAC AGG C-3' (FRAG 600) (SEQ. ID NO: 610) 5'- GA GAT GGA GGG CGG CAT GGC GGG CAC AGG -3' (FRAG 601) (SEQ. ID NO: 611) 5'- GA GAT GGA GGG CGG CAT GGC GGG CAC AG-3' FRAGG 602) (SEQ. ID NO: 612) 5'- GA GAT GGA GGG CGG CAT GGC GGG CAC A-3' FRAGG 603) (SEQ. ID NO: 613) 5'- GA GAT GGA GGG CGG CAT GGC GGG CAC-3' FRAGG 604) (SEQ. ID NO: 614) 5'- GA GAT GGA GGG CGG CAT GGC GGG CA-3' FRAGG 605) (SEQ. ID NO: 615) 5'- GA GAT GGA GGG CGG CAT GGC GGG C-3' FRAGG 606) (SEQ. ID NO: 616) 5'- GA GAT GGA GGG CGG CAT GGC GGG -3' FRAGG 607) (SEQ. ID NO: 617) 5'- GA GAT GGA GGG CGG CAT GGC GG-3' FRAGG 608) (SEQ. ID NO: 618) 5'- GA GAT GGA GGG CGG CAT GGC G-3' (FRAG 609) (SEQ. ID NO: 619) 5'- GA GAT GGA GGG CGG CAT GGC -3' (FRAG 610) (SEQ. ID NO: 620) 5'- GA GAT GGA GGG CGG CAT GG -3' (FRAG 611) (SEQ. ID NO: 621) 5'- GA GAT GGA GGG CGG CAT G -3' (FRAG 612) (SEQ. ID NO: 622) 5'- GA GAT GGA GGG CGG CAT -3' (FRAG 613) (SEQ. ID NO: 623) 5'- GA GAT GGA GGG CGG CA-3' (FRAG 614) (SEQ. ID NO: 624) 5'- GA GAT GGA GGG CGG C-3' (FRAG 615) (SEQ. ID NO: 625) 5'- GA GAT GGA GGG CGG -3' (FRAG 616) (SEQ. ID NO: 626) 5'- GA GAT GGA GGG CG -3' FRAGG 617) (SEQ. ID NO: 627) 5'- GA GAT GGA GGG C -3' FRAGG 618) (SEQ. ID NO: 628) 5'- GA GAT GGA GGG -3' (FRAG 619) (SEQ. ID NO: 629) WO 00/09525 PCT/US99/17712 EPI-109 96 5'- GA GAT GGA GG -3' (FRAG 620) (SEQ. ID NO: 630) 5'- A GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (FRAG 621) (SEQ. ID NO: 631) 5'- A GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GG-3' (FRAG 622) (SEQ. ID NO: 632) 5'- A GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG G-3' (FRAG 623) (SEQ. ID NO: 633) 5'- A GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG -3' (FRAG 624) (SEQ. ID NO: 634) 5'- A GAT GGA GGG CGG CAT GGC GGG CAC AGG CT-3' (FRAG 625) (SEQ. ID NO: 635) 5'- A GAT GGA GGG CGG CAT GGC GGG CAC AGG C-3' (FRAG 626) (SEQ. ID NO: 636) 5'- A GAT GGA GGG CGG CAT GGC GGG CAC AGG -3' (FRAG 627) (SEQ. ID NO: 637) 5'- A GAT GGA GGG CGG CAT GGC GGG CAC AG-3' (FRAG 628) (SEQ. ID NO: 638) 5'- A GAT GGA GGG CGG CAT GGC GGG CAC A-3' (FRAG 629) (SEQ. ID NO: 639) 5'- A GAT GGA GGG CGG CAT GGC GGG CAC-3' (FRAG 630) (SEQ. ID NO: 640) 5'- A GAT GGA GGG CGG CAT GGC GGG CA-3' (FRAG 631) (SEQ. ID NO: 641) 5'- A GAT GGA GGG CGG CAT GGC GGG C-3' (FRAG 632) (SEQ. ID NO: 642) 5'- A GAT GGA GGG CGG CAT GGC GGG -3' (FRAG 633) (SEQ. ID NO: 643) 5'- A GAT GGA GGG CGG CAT GGC GG-3' (FRAG 634) (SEQ. ID NO: 644) 5'- A GAT GGA GGG CGG CAT GGC G-3' (FRAG 635) (SEQ. ID NO: 645) 5'- A GAT GGA GGG CGG CAT GGC -3' (FRAG 636) (SEQ. ID NO: 646) 5'- A GAT GGA GGG CGG CAT GG -3' (FRAG 637) (SEQ. ID NO: 647) 5'- A GAT GGA GGG CGG CAT G -3' (FRAG 638) (SEQ. ID NO: 648) 5'- A GAT GGA GGG CGG CAT -3' (FRAG 639) (SEQ. ID NO: 649) 5'- A GAT GGA GGG CGG CA-3' (FRAG 640) (SEQ. ID NO: 650) 5'- A GAT GGA GGG CGG C-3' (FRAG 641) (SEQ. ID NO: 651) 5'- A GAT GGA GGG CGG -3' (FRAG 642) (SEQ. ID NO: 652) 5'- A GAT GGA GGG CG -3' (FRAG 643) (SEQ. ID NO: 653) 5'- A GAT GGA GGG C -3' (FRAG 644) (SEQ. ID NO: 654) 5'- A GAT GGA GGG -3' (FRAG 645) (SEQ. ID NO: 655) 5'- GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (FRAG 646) (SEQ. ID NO: 656) 5'- GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GG-3' (FRAG 647) (SEQ. ID NO: 657) 5'- GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG G-3' (FRAG 648) (SEQ. ID NO: 658) 5'- GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG -3' FRAGG 6) (SEQ. ID NO: 659) 5'- GAT GGA GGG CGG CAT GGC GGG CAC AGG CT-3' FRAGG 650) (SEQ. ID NO: 660) 5'- GAT GGA GGG CGG CAT GGC GGG CAC AGG C-3' (FRAG 651) (SEQ. ID NO: 661) 5'- GAT GGA GGG CGG CAT GGC GGG CAC AGG -3' FRAGG 652) (SEQ. ID NO: 662) 5'- GAT GGA GGG CGG CAT GGC GGG CAC AG-3' FRAGG 653) (SEQ. ID NO: 663) 5'- GAT GGA GGG CGG CAT GGC GGG CAC A-3' FRAGG 654) (SEQ. ID NO: 664) 5'- GAT GGA GGG CGG CAT GGC GGG CAC-3' (FRAG 655) (SEQ. ID NO: 665) 5'- GAT GGA GGG CGG CAT GGC GGG CA-3' (FRAG 656) (SEQ. ID NO: 666) 5'- GAT GGA GGG CGG CAT GGC GGG C-3' (FRAG 657) (SEQ. ID NO: 667) 5'- GAT GGA GGG CGG CAT GGC GGG -3' (FRAG 658) (SEQ. ID NO: 668) 5'- GAT GGA GGG CGG CAT GGC GG-3' (FRAG 659) (SEQ. ID NO: 669) 5'- GAT GGA GGG CGG CAT GGC G-3' (FRAG 660) (SEQ. ID NO: 670) 5'- GAT GGA GGG CGG CAT GGC -3' (FRAG 661) (SEQ. ID NO: 671) 5'- GAT GGA GGG CGG CAT GG -3' FRAGG 662) (SEQ. ID NO: 672) 5'- GAT GGA GGG CGG CAT G -3' FRAGG 663) (SEQ. ID NO: 673) 5'- GAT GGA GGG CGG CAT -3' (FRAG 664) (SEQ. ID NO: 674) 5'- GAT GGA GGG CGG CA-3' (FRAG 665) (SEQ. ID NO: 675) 5'- GAT GGA GGG CGG C-3' (FRAG 666) (SEQ. ID NO: 676) 5'- GAT GGA GGG CGG -3' (FRAG 667) (SEQ. ID NO: 677) 5'- GAT GGA GGG CG -3' (FRAG 668) (SEQ. ID NO: 678) 5'- GAT GGA GGG C -3' (FRAG 669) (SEQ. ID NO: 679) 5'- AT GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (FRAG 670) (SEQ. ID NO: 680) 5'- AT GGA GGG CGG CAT GGC GGG CAC AGG CTG GG-3' FRAGG 671) (SEQ. ID NO: 681) 5'- AT GGA GGG CGG CAT GGC GGG CAC AGG CTG G-3' (FRAG 672) (SEQ. ID NO: 682) 5'- AT GGA GGG CGG CAT GGC GGG CAC AGG CTG -3' (FRAG 673) (SEQ. ID NO: 683) 5'- AT GGA GGG CGG CAT GGC GGG CAC AGG CT-3' (FRAG 674) (SEQ. ID NO: 684) 5'- AT GGA GGG CGG CAT GGC GGG CAC AGG C-3' (FRAG 675) (SEQ. ID NO: 685) 5'- AT GGA GGG CGG CAT GGC GGG CAC AGG -3' (FRAG 676) (SEQ. ID NO: 686) 5'- AT GGA GGG CGG CAT GGC GGG CAC AG-3' (FRAG 677) (SEQ. ID NO: 687) 5'- AT GGA GGG CGG CAT GGC GGG CAC A-3' (FRAG 678) (SEQ. ID NO: 688) 5'- AT GGA GGG CGG CAT GGC GGG CAC-3' (FRAG 679) (SEQ. ID NO: 689) 5'- AT GGA GGG CGG CAT GGC GGG CA-3' (FRAG 680) (SEQ. ID NO: 690) 5'- AT GGA GGG CGG CAT GGC GGG C-3' FRAGG 681) (SEQ. ID NO: 691) 5'- AT GGA GGG CGG CAT GGC GGG -3' (FRAG 682) (SEQ. ID NO: 692) 5'- AT GGA GGG CGG CAT GGC GG-3' FRAGG 683) (SEQ. ID NO: 693) 5'- AT GGA GGG CGG CAT GGC G-3' (FRAG 684) (SEQ. ID NO: 694) 5'- AT GGA GGG CGG CAT GGC -3' (FRAG 685) (SEQ. ID NO: 695) 5'- AT GGA GGG CGG CAT GG -3' FRAGG 686) (SEQ. ID NO: 696) 5- AT GGA GGG CGG CAT G -3' (FRAG 687) (SEQ. ID NO: 697) 5'- AT GGA GGG CGG CAT -3' (FRAG 688) (SEQ. ID NO: 698) WO 00/09525 PCT/US99/17712 EPI-109 97 5'- AT GGA GGG CGG CA-3' (FRAG 689) (SEQ. ID NO: 699) 5'- AT GGA GGG CGG C-3' (FRAG 690) (SEQ. ID NO: 700) 5'- AT GGA GGG CGG -3' (FRAG 691) (SEQ. ID NO: 701) 5'- AT GGA GGG CG -3' FRAGG 692) (SEQ. ID NO: 702) 5'- T GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' FRAGG 693) (SEQ. ID NO: 703) 5'- T GGA GGG CGG CAT GGC GGG CAC AGG CTG GG-3' (FRAG 694) (SEQ. ID NO: 704) 5'- T GGA GGG CGG CAT GGC GGG CAC AGG CTG G-3' (FRAG 695) (SEQ. ID NO: 705) 5'- T GGA GGG CGG CAT GGC GGG CAC AGG CTG -3' (FRAG 696) (SEQ. ID NO: 706) 5'- T GGA GGG CGG CAT GGC GGG CAC AGG CT-3' (FRAG 697) (SEQ. ID NO: 707) 5'- T GGA GGG CGG CAT GGC GGG CAC AGG C-3' FRAGG 698) (SEQ. ID NO: 708) 5'- T GGA GGG CGG CAT GGC GGG CAC AGG -3' FRAGG 699) (SEQ. ID NO: 709) 5'- T GGA GGG CGG CAT GGC GGG CAC AG-3' FRAGG 700) (SEQ. ID NO: 710) 5'- T GGA GGG CGG CAT GGC GGG CAC A-3' FRAGG 701) (SEQ. ID NO: 711) 5'- T GGA GGG CGG CAT GGC GGG CAC-3' FRAGG 702) (SEQ. ID NO: 712) 5'- T GGA GGG CGG CAT GGC GGG CA-3' FRAGG 703) (SEQ. ID NO: 713) 5'- T GGA GGG CGG CAT GGC GGG C-3' FRAGG 704) (SEQ. ID NO: 714) 5'- T GGA GGG CGG CAT GGC GGG -3' FRAGG 705) (SEQ. ID NO: 715) 5'- T GGA GGG CGG CAT GGC GG-3' (FRAG 706) (SEQ. ID NO: 716) 5'- T GGA GGG CGG CAT GGC G-3' FRAGG 707) (SEQ. ID NO: 717) 5'- T GGA GGG CGG CAT GGC -3' FRAGG 708) (SEQ. ID NO: 718) 5'- T GGA GGG CGG CAT GG -3' FRAGG 709) (SEQ. ID NO: 719) 5'- T GGA GGG CGG CAT G -3' FRAGG 710) (SEQ. ID NO: 720) 5'- T GGA GGG CGG CAT -3' FRAGG 711) (SEQ. ID NO: 721) 5'- T GGA GGG CGG CA-3' FRAGG 712) (SEQ. ID NO: 722) 5'- T GGA GGG CGG C-3' FRAGG 713) (SEQ. ID NO: 723) 5'- T GGA GGG CGG -3' FRAGG 714) (SEQ. ID NO: 724) 5'- GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' FRAGG 715) (SEQ. ID NO: 725) 5'- GGA GGG CGG CAT GGC GGG CAC AGG CTG GG-3' FRAGG 716) (SEQ. ID NO: 726) 5'- GGA GGG CGG CAT GGC GGG CAC AGG CTG G-3' FRAGG 717) (SEQ. ID NO: 727) 5'- GGA GGG CGG CAT GGC GGG CAC AGG CTG -3' FRAGG 718) (SEQ. ID NO: 728) 5'- GGA GGG CGG CAT GGC GGG CAC AGG CT-3' FRAGG 719) (SEQ. ID NO: 729) 5'- GGA GGG CGG CAT GGC GGG CAC AGG C-3' FRAGG 720) (SEQ. ID NO: 730) 5'- GGA GGG CGG CAT GGC GGG CAC AGG -3' FRAGG 721) (SEQ. ID NO: 731) 5'- GGA GGG CGG CAT GGC GGG CAC AG-3' FRAGG 722) (SEQ. ID NO: 732) 5'- GGA GGG CGG CAT GGC GGG CAC A-3' FRAGG 723) (SEQ. ID NO: 733) 5'- GGA GGG CGG CAT GGC GGG CAC-3' FRAGG 724) (SEQ. ID NO: 734) 5'- GGA GGG CGG CAT GGC GGG CA-3' FRAGG 725) (SEQ. ID NO: 735) 5'- GGA GGG CGG CAT GGC GGG C-3' FRAGG 726) (SEQ. ID NO: 736) 5'- GGA GGG CGG CAT GGC GGG -3' FRAGG 727) (SEQ. ID NO: 737) 5'- GGA GGG CGG CAT GGC GG-3' FRAGG 728) (SEQ. ID NO: 738) 5'- GGA GGG CGG CAT GGC G-3' FRAGG 729) (SEQ. ID NO: 739) 5'- GGA GGG CGG CAT GGC -3' FRAGG 730) (SEQ. ID NO: 740) 5'- GGA GGG CGG CAT GG -3' FRAGG 731) (SEQ. ID NO: 741) 5'- GGA GGG CGG CAT G -3' FRAGG 732) (SEQ. ID NO: 742) 5'- GGA GGG CGG CAT -3' FRAGG 733) (SEQ. ID NO: 743) 5'- GGA GGG CGG CA-3' FRAGG 734) (SEQ. ID NO: 744) 5'- GGA GGG CGG C-3' FRAGG 735) (SEQ. ID NO: 745) 5'- GA GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' FRAGG 736) (SEQ. ID NO: 746) 5'- GA GGG CGG CAT GGC GGG CAC AGG CTG GG-3' FRAGG 737) (SEQ. ID NO: 747) 5'- GA GGG CGG CAT GGC GGG CAC AGG CTG G-3' FRAGG 738) (SEQ. ID NO: 748) 5'- GA GGG CGG CAT GGC GGG CAC AGG CTG -3' FRAGG 739) (SEQ. ID NO: 749) 5'- GA GGG CGG CAT GGC GGG CAC AGG CT-3' FRAGG 740) (SEQ. ID NO: 750) 5'- GA GGG CGG CAT GGC GGG CAC AGG C-3' FRAGG 741) (SEQ. ID NO: 751) 5'- GA GGG CGG CAT GGC GGG CAC AGG -3' FRAGG 742) (SEQ. ID NO: 752) 5'- GA GGG CGG CAT GGC GGG CAC AG-3' FRAGG 743) (SEQ. ID NO: 753) 5'- GA GGG CGG CAT GGC GGG CAC A-3' FRAGG 744) (SEQ. ID NO: 754) 5'- GA GGG CGG CAT GGC GGG CAC-3' FRAGG 745) (SEQ. ID NO: 755) 5'- GA GGG CGG CAT GGC GGG CA-3' FRAGG 746) (SEQ. ID NO: 756) 5'- GA GGG CGG CAT GGC GGG C-3' FRAGG 747) (SEQ. ID NO: 757) 5'- GA GGG CGG CAT GGC GGG -3' FRAGG 748) (SEQ. ID NO: 758) 5'- GA GGG CGG CAT GGC GG-3' FRAGG 749) (SEQ. ID NO: 759) 5'- GA GGG CGG CAT GGC G-3' FRAGG 750) (SEQ. ID NO: 760) 5'- GA GGG CGG CAT GGC -3' FRAGG 751) (SEQ. ID NO: 761) 5'- GA GGG CGG CAT GG -3' FRAGG 752) (SEQ. ID NO: 762) 5'- GA GGG CGG CAT G -3' FRAGG 753) (SEQ. ID NO: 763) 5'- GA GGG CGG CAT -3' FRAGG 754) (SEQ. ID NO: 764) 5'- GA GGG CGG CA-3' FRAGG 755) (SEQ. ID NO: 765) 5'- A GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' FRAGG 756) (SEQ. ID NO: 766) 5'- A GGG CGG CAT GGC GGG CAC AGG CTG GG-3' FRAGG 757) (SEQ. ID NO: 767) WO 00/09525 PCT/US99/17712 EPI-109 98 5'- A GGG CGG CAT GGC GGG CAC AGG CTG G-3' (FRAG 758) (SEQ. ID NO: 768) 5'- A GGG CGG CAT GGC GGG CAC AGG CTG -3' (FRAG 759) (SEQ. ID NO: 769) 5'- A GGG CGG CAT GGC GGG CAC AGG CT-3' (FRAG 760) (SEQ. ID NO: 770) 5'- A GGG CGG CAT GGC GGG CAC AGG C-3' (FRAG 761) (SEQ. ID NO: 771) 5'- A GGG CGG CAT GGC GGG CAC AGG -3' (FRAG 762) (SEQ. ID NO: 772) 5'- A GGG CGG CAT GGC GGG CAC AG-3' (FRAG 763) (SEQ. ID NO: 773) 5'- A GGG CGG CAT GGC GGG CAC A-3' (FRAG 764) (SEQ. ID NO: 774) 5'- A GGG CGG CAT GGC GGG CAC-3' (FRAG 765) (SEQ. ID NO: 775) 5'- A GGG CGG CAT GGC GGG CA-3' (FRAG 766) (SEQ. ID NO: 776) 5'- A GGG CGG CAT GGC GGG C-3' (FRAG 767) (SEQ. ID NO: 777) 5'- A GGG CGG CAT GGC GGG -3' (FRAG 768) (SEQ. ID NO: 778) 5'- A GGG CGG CAT GGC GG-3' (FRAG 769) (SEQ. ID NO: 779) 5'- A GGG CGG CAT GGC G-3' (FRAG 770) (SEQ. ID NO: 780) 5'- A GGG CGG CAT GGC -3' (FRAG 771) (SEQ. ID NO: 781) 5'- A GGG CGG CAT GG -3' (FRAG 772) (SEQ. ID NO: 782) 5'- A GGG CGG CAT G -3' (FRAG 773) (SEQ. ID NO: 783) 5'- A GGG CGG CAT -3' (FRAG 774) (SEQ. ID NO: 784) 5'- GGG CGG CAT GGC GGG CAC AGG CTG GGC-3' (FRAG 775) (SEQ. ID NO: 785) 5'- GGG CGG CAT GGC GGG CAC AGG CTG GG-3' (FRAG 776) (SEQ. ID NO: 786) 5'- GGG CGG CAT GGC GGG CAC AGG CrG G-3' (FRAG 777) (SEQ. ID NO: 787) 5'- GGG CGG CAT GGC GGG CAC AGG CTG -3' (FRAG 778) (SEQ. ID NO: 788) 5'- GGG CGG CAT GGC GGG CAC AGG CT-3' (FRAG 779) (SEQ. ID NO: 789) 5'- GGG CGG CAT GGC GGG CAC AGG C-3' (FRAG 780) (SEQ. ID NO: 790) 5'- GGG CGG CAT GGC GGG CAC AGG -3' (FRAG 781) (SEQ. ID NO: 791) 5'- GGG CGG CAT GGC GGG CAC AG-3' (FRAG 782) (SEQ. ID NO: 792) 5'- GGG CGG CAT GGC GGG CAC A-3' (FRAG 783) (SEQ. ID NO: 793) 5'- GGG CGG CAT GGC GGG CAC-3' (FRAG 784) (SEQ. ID NO: 794) 5'- GGG CGG CAT GGC GGG CA-3' (FRAG 785) (SEQ. ID NO: 795) 5'- GGG CGG CAT GGC GGG C-3' (FRAG 786) (SEQ. ID NO: 796) 5'- GGG CGG CAT GGC GGG -3' (FRAG 787) (SEQ. ID NO: 797) 5'- GGG CGG CAT GGC GG-3' (FRAG 788) (SEQ. ID NO: 798) 5'- GGG CGG CAT GGC G-3' FRAGG 789) (SEQ. ID NO: 799) 5'- GGG CGG CAT GGC -3' (FRAG 790) (SEQ. ID NO: 800) 5'- GGG CGG CAT GG -3' (FRAG 791) (SEQ. ID NO: 801) 5'- GGG CGG CAT G -3' (FRAG 792) (SEQ. ID NO: 802) 5'- GG CGG CAT GGC GGG CAC AG G CTG GGC-3' (FRAG 793) (SEQ. ID NO: 803) 5'- GG CGG CAT GGC GGG CAC AGG CTG GG-3' (FRAG 794) (SEQ. ID NO: 804) 5'- GG CGG CAT GGC GGG CAC AGG CTG G-3' (FRAG 795) (SEQ. ID NO: 805) 5'- GG CGG CAT GGC GGG CAC AGG CTG -3' (FRAG 796) (SEQ. ID NO: 806) 5'- GG CGG CAT GGC GGG CAC AGG CT-3' (FRAG 797) (SEQ. ID NO: 807) 5'- GG CGG CAT GGC GGG CAC AGG C-3' (FRAG 798) (SEQ. ID NO: 808) 5'- GG CGG CAT GGC GGG CAC AGG -3' (FRAG 799) (SEQ. ID NO: 809) 5'- GG CGG CAT GGC GGG CAC AG-3' (FRAG 800) (SEQ. ID NO: 810) 5'- GG CGG CAT GGC GGG CAC A-3' (FRAG 801) (SEQ. ID NO: 811) 5'- GG CGG CAT GGC GGG CAC-3' (FRAG 802) (SEQ. ID NO: 812) 5'- GG CGG CAT GGC GGG CA-3' (FRAG 803) (SEQ. ID NO: 813) 5'- GG CGG CAT GGC GGG C-3' (FRAG 804) (SEQ. ID NO: 814) 5'- GG CGG CAT GGC GGG -3' (FRAG 805) (SEQ. ID NO: 815) 5'- GG CGG CAT GGC GG-3' (FRAG 806) (SEQ. ID NO: 816) 5'- GG CGG CAT GGC G-3' (FRAG 807) (SEQ. ID NO: 817) 5'- GG CGG CAT GGC -3' (FRAG 808) (SEQ. ID NO: 818) 5'- GG CGG CAT GG -3' (FRAG 809) (SEQ. ID NO: 819) 5'- G CGG CAT GGC GGG CAC AGG CTG GGC-3' (FRAG 810) (SEQ. ID NO: 820) 5'- G CGG CAT GGC GGG CAC AGG CTG GG-3' FRAGG 811) (SEQ. ID NO: 821) 5'- G CGG CAT GGC GGG CAC AGG CTG G-3' (FRAG 812) (SEQ. ID NO: 822) 5'- G CGG CAT GGC GGG CAC AGG CTG -3' (FRAG 813) (SEQ. ID NO: 823) 5'- G CGG CAT GGC GGG CAC AGG CT-3' (FRAG 814) (SEQ. ID NO: 824) 5'- G CGG CAT GGC GGG CAC AGG C-3' (FRAG 815) (SEQ. ID NO: 825) 5'- G CGG CAT GGC GGG CAC AGG -3' (FRAG 816) (SEQ. ID NO: 826) 5'- G CGG CAT GGC GGG CAC AG-3' (FRAG 817) (SEQ. ID NO: 827) 5'- G CGG CAT GGC GGG CAC A-3' (FRAG 818) (SEQ. ID NO: 828) 5'- G CGG CAT GGC GGG CAC-3' (FRAG 819) (SEQ. ID NO: 829) 5'- G CGG CAT GGC GGG CA-3' (FRAG 820) (SEQ. ID NO: 830) 5'- G CGG CAT GGC GGG C-3' (FRAG 821) (SEQ. ID NO: 831) 5'- G CGG CAT GGC GGG -3' (FRAG 822) (SEQ. ID NO: 832) 5'- G CGG CAT GGC GG-3' (FRAG 823) (SEQ. ID NO: 833) 5'- G CGG CAT GGC G-3' (FRAG 824) (SEQ. ID NO: 834) 5'- G CGG CAT GGC -3' (FRAG 825) (SEQ. ID NO: 835) 5'- CGG CAT GGC GGG CAC AGG CTG GGC-3' (FRAG 826) (SEQ. ID NO: 836) WO 00/09525 PCT/US99/17712 EPI-109 99 5'- CGG CAT GGC GGG CAC AGG CTG GG-3' (FRAG 827) (SEQ. ID NO: 837) 5'- CGG CAT GGC GGG CAC AGG CTG G-3' (FRAG 828) (SEQ. ID NO: 838) 5'- CGG CAT GGC GGG CAC AGG CTG -3' (FRAG 829) (SEQ. ID NO: 839) 5'- CGG CAT GGC GGG CAC AGG CT-3' (FRAG 830) (SEQ. ID NO: 840) 5'- CGG CAT GGC GGG CAC AGG C-3' (FRAG 831) (SEQ. ID NO: 841) 5'- CGG CAT GGC GGG CAC AGG -3' (FRAG 832) (SEQ. ID NO: 842) 5'- CGG CAT GGC GGG CAC AG-3' (FRAG 833) (SEQ. ID NO: 843) 5'- CGG CAT GGC GGG CAC A-3' (FRAG 834) (SEQ. ID NO: 844) 5'- CGG CAT GGC GGG CAC-3' (FRAG 835) (SEQ. ID NO: 845) 5'- CGG CAT GGC GGG CA-3' (FRAG 836) (SEQ. ID NO: 846) 5'- CGG CAT GGC GGG C-3' (FRAG 837) (SEQ. ID NO: 847) 5'- CGG CAT GGC GGG -3' (FRAG 838) (SEQ. ID NO: 848) 5'- CGG CAT GGC GG-3' (FRAG 839) (SEQ. ID NO: 849) 5'- CGG CAT GGC G-3' (FRAG 840) (SEQ. ID NO: 850) 5'- GG CAT GGC GGG CAC AGG C TG GGC-3' (FRAG 841) (SEQ. ID NO: 851) 5'- GG CAT GGC GGG CAC AGG CTG GG-3' (FRAG 842) (SEQ. ID NO: 852) 5'- GG CAT GGC GGG CAC AGG CTG G-3' (FRAG 843) (SEQ. ID NO: 853) 5'- GG CAT GGC GGG CAC AGG CTG -3' (FRAG 844) (SEQ. ID NO: 854) 5'- GG CAT GGC GGG CAC AGG CT-3' (FRAG 845) (SEQ. ID NO: 855) 5'- GG CAT GGC GGG CAC AGG C-3' (FRAG 846) (SEQ. ID NO: 856) 5'- GG CAT GGC GGG CAC AGG -3' (FRAG 847) (SEQ. ID NO: 857) 5'- GG CAT GGC GGG CAC AG-3' (FRAG 848) (SEQ. ID NO: 858) 5'- GG CAT GGC GGG CAC A-3' FRAGG 849) (SEQ. ID NO: 859) 5'- GG CAT GGC GGG CAC-3' (FRAG 850) (SEQ. ID NO: 860) 5'- GG CAT GGC GGG CA-3' (FRAG 851) (SEQ. ID NO: 861) 5'- GG CAT GGC GGG C-3' (FRAG 852) (SEQ. ID NO: 862) 5'- GG CAT GGC GGG -3' (FRAG 853) (SEQ. ID NO: 863) 5'- GG CAT GGC GG-3' (FRAG 854) (SEQ. ID NO: 864) 5'- G CAT GGC GGG CAC AGG CTG GGC-3' (FRAG 855) (SEQ. ID NO: 865) 5'- G CAT GGC GGG CAC AGG CTG GG-3' (FRAG 856) (SEQ. ID NO: 866) 5'- G CAT GGC GGG CAC AGG CTG G-3' (FRAG 857) (SEQ. ID NO: 867) 5'- G CAT GGC GGG CAC AGG CTG -3' (FRAG 858) (SEQ. ID NO: 868) 5'- G CAT GGC GGG CAC AGG CT-3' (FRAG 859) (SEQ. ID NO: 869) 5'- G CAT GGC GGG CAC AGG C-3' (FRAG 860) (SEQ. ID NO: 870) 5'- G CAT GGC GGG CAC AGG -3' (FRAG 861) (SEQ. ID NO: 871) 5'- G CAT GGC GGG CAC AG-3' (FRAG 862) (SEQ. ID NO: 872) 5'- G CAT GGC GGG CAC A-3' (FRAG 863) (SEQ. ID NO: 873) 5'- G CAT GGC GGG CAC-3' (FRAG 864) (SEQ. ID NO: 874) 5'- G CAT GGC GGG CA-3' (FRAG 865) (SEQ. ID NO: 875) 5'- G CAT GGC GGG C-3' (FRAG 866) (SEQ. ID NO: 876) 5'- G CAT GGC GGG -3' (FRAG 867) (SEQ. ID NO: 877) 5'- CAT GGC GGG CAC AGG CTG GGC-3' (FRAG 868) (SEQ. ID NO: 878) 5'- CAT GGC GGG CAC AGG CTG GG-3' (FRAG 869) (SEQ. ID NO: 879) 5'- CAT GGC GGG CAC AGG CTG G-3' (FRAG 870) (SEQ. ID NO: 880) 5'- CAT GGC GGG CAC AGG CTG -3' (FRAG 871) (SEQ. ID NO: 881) 5'- CAT GGC GGG CAC AGG CT-3' (FRAG 872) (SEQ. ID NO: 882) 5'- CAT GGC GGG CAC AGG C-3' (FRAG 873) (SEQ. ID NO: 883) 5'- CAT GGC GGG CAC AGG -3' (FRAG 874) (SEQ. ID NO: 884) 5'- CAT GGC GGG CAC AG-3' (FRAG 875) (SEQ. ID NO: 885) 5'- CAT GGC GGG CAC A-3' (FRAG 876) (SEQ. ID NO: 886) 5'- CAT GGC GGG CAC-3' (FRAG 877) (SEQ. ID NO: 887) 5'- CAT GGC GGG CA-3' (FRAG 878) (SEQ. ID NO: 888) 5'- CAT GGC GGG C-3' (FRAG 879) (SEQ. ID NO: 889) 5- AT GGC GGG CAC AGG CTG GGC-3' (FRAG 880) (SEQ. ID NO: 890) 5'- AT GGC GGG CAC AGG CTG GG-3' (FRAG 881) (SEQ. ID NO: 891) 5'- AT GGC GGG CAC AGG CTG G-3' FRAGG 882) (SEQ. ID NO: 892) 5'- AT GGC GGG CAC AGG CTG -3' (FRAG 883) (SEQ. ID NO: 893) 5'- AT GGC GGG CAC AGG CT-3' (FRAG 884) (SEQ. ID NO: 894) 5'- AT GGC GGG CAC AGG C-3' (FRAG 885) (SEQ. ID NO: 895) 5'- AT GGC GGG CAC AGG -3' (FRAG 886) (SEQ. ID NO: 896) 5'- AT GGC GGG CAC AG-3' FRAGG 887) (SEQ. ID NO: 897) 5- AT GGC GGG CAC A-3' FRAGG 888) (SEQ. ID NO: 898) 5'- AT GGC GGG CAC-3' FRAGG 889) (SEQ. ID NO: 899) 5'- AT GGC GGG CA-3' FRAGG 890) (SEQ. ID NO: 900) 5'- T GGC GGG CAC AGG CTG GGC-3' (FRAG 891) (SEQ. ID NO: 901) 5'- T GGC GGG CAC AGG CTG GG-3' (FRAG 892) (SEQ. ID NO: 902) 5'- T GGC GGG CAC AGG CTG G-3' (FRAG 893) (SEQ. ID NO: 903) 5'- T GGC GGG CAC AGG CTG -3' (FRAG 894) (SEQ. ID NO: 904) 5'- T GGC GGG CAC AGG CT-3' FRAGG 895) (SEQ. ID NO: 905) WO 00/09525 PCT/US99/17712 EPI-109 100 5'- T GGC GGG CAC AGG C-3' (FRAG 896) (SEQ. ID NO: 906) 5'- T GGC GGG CAC AGG -3' (FRAG 897) (SEQ. ID NO: 907) 5'- T GGC GGG CAC AG-3' (FRAG 898) (SEQ. ID NO: 908) 5'- T GGC GGG CAC A-3' (FRAG 899) (SEQ. ID NO: 909) 5'- T GGC GGG CAC-3' (FRAG 900) (SEQ. ID NO: 910) 5'- GGC GGG CAC AGG CTG GGC-3' (FRAG 901) (SEQ. ID NO: 911) 5'- GGC GGG CAC AGG CTG GG-3' (FRAG 902) (SEQ. ID NO: 912) 5'- GGC GGG CAC AGG CTG G-3' (FRAG 903) (SEQ. ID NO: 913) 5'- GGC GGG CAC AGG CTG -3' (FRAG 904) (SEQ. ID NO: 914) 5'- GGC GGG CAC AGG CT-3' (FRAG 905) (SEQ. ID NO: 915) 5'- GGC GGG CAC AGG C-3' (FRAG 906) (SEQ. ID NO: 916) 5'- GGC GGG CAC AGG -3' (FRAG 907) (SEQ. ID NO: 917) 5'- GGC GGG CAC AG-3' (FRAG 908) (SEQ. ID NO: 918) 5'- GGC GGG CAC A-3' (FRAG 909) (SEQ. ID NO: 919) 5'- GC GGG CAC AGG CTG GGC-3' (FRAG 910) (SEQ. ID NO: 920) 5'- GC GGG CAC AGG CTG GG-3' (FRAG 911) (SEQ. ID NO: 921) 5'- GC GGG CAC AGG CTG G-3' (FRAG 912) (SEQ. ID NO: 922) 5'- GC GGG CAC AGG CTG -3' (FRAG 913) (SEQ. ID NO: 923) 5'- GC GGG CAC AGG CT-3' (FRAG 914) (SEQ. ID NO: 924) 5'- GC GGG CAC AGG C-3' (FRAG 915) (SEQ. ID NO: 925) 5'- GC GGG CAC AGG -3' (FRAG 916) (SEQ. ID NO: 926) 5'- GC GGG CAC AG-3' (FRAG 917) (SEQ. ID NO: 927) 5'- C GGG CAC AGG CTG GGC-3' (FRAG 918) (SEQ. ID NO: 928) 5'- GGG CAC AGG CTG GG-3' (FRAG 919) (SEQ. ID NO: 929) 5'- C GGG CAC AGG CTG G-3' (FRAG 920) (SEQ. ID NO: 930) 5'- C GGG CAC AGG CTG -3' (FRAG 921) (SEQ. ID NO: 931) 5'- C GGG CAC AGG CT-3' (FRAG 922) (SEQ. ID NO: 932) 5'- C GGG CAC AGG C-3' (FRAG 923) (SEQ. ID NO: 933) 5'- C GGG CAC AGG -3' (FRAG 924) (SEQ. ID NO: 934) 5'- GGG CAC AGG CTG GGC-3' (FRAG 925) (SEQ. ID NO: 935) 5'- GGG CAC AGG CTG GG-3' (FRAG 926) (SEQ. ID NO: 936) 5'- GGG CAC AGG CTG G-3' (FRAG 927) (SEQ. ID NO: 937) 5'- GGG CAC AGG CTG -3' (FRAG 928) (SEQ. ID NO: 938) 5'- GGG CAC AGG CT-3' (FRAG 929) (SEQ. ID NO: 939) 5'- GGG CAC AGG C-3' (FRAG 930) (SEQ. ID NO: 940) 5'- GG CAC AGG CTG GGC-3' (FRAG 931) (SEQ. ID NO: 941) 5'- GG CAC AGG CTG GG-3' (FRAG 932) (SEQ. ID NO: 942) 5'- GG CAC AGG CTG G-3' (FRAG 933) (SEQ. ID NO: 943) 5'-GG CAC AGG CTG -3' (FRAG 934) (SEQ. ID NO: 944) 5'- GG CAC AGG Cr-3' (FRAG 935) (SEQ. ID NO: 945) 5'-G CAC AGG CTG GGC-3' (FRAG 936) (SEQ. ID NO: 946) 5'-G CAC AGG CTG GG-3' (FRAG 937) (SEQ. ID NO: 947) 5'-G CAC AGG CTG G-3' (FRAG 938) (SEQ. ID NO: 948) 5'-G CAC AGG CTG -3' (FRAG 939) (SEQ. ID NO: 949) 5'-CAC AGG CTG GGC-3' (FRAG 940) (SEQ. ID NO: 950) 5'-CAC AGG CTG GG-3' (FRAG 941) (SEQ. ID NO: 951) 5'-CAC AGG CrG G-3' (FRAG 942) (SEQ. ID NO: 952) 5'-AC AGG CrG GGC-3' (FRAG 943) (SEQ. ID NO: 953) 5'-AC AGG CrG GG-3' (FRAG 944) (SEQ. ID NO: 954) 5-C AGG CTG GGC-3' (FRAG 945) (SEQ. ID NO: 955) 5'-TTT TCC TTC CTT TGT CTC TCT TC (FRAG 946) (SEQ. ID NO: 956) 5'-GCT CCC GGC TGC CTG (FRAG 947) (SEQ. ID NO: 957) 5'-CTC GGC CGT GCG GCT CrG TCG CTC CCG GT (FRAG 948) (SEQ. ID NO: 958) 5'-CCG CCG CCC TCC GGG GGG TC (FRAG 949) (SEQ. ID NO: 959) 5'-TGC TGC CGT TGG CTG CCC (FRAG 950) (SEQ. ID NO: 960) 5'-CTT CTG CGG GTC GCC GG (FRAG 951) (SEQ. ID NO: 961) 5'-TGC TGG GCT TGT GGC (FRAG 952) (SEQ. ID NO: 962) 5'-GGC CTC TCT TCT GGG (FRAG 953) (SEQ. ID NO: 963) 5'-CCT GGT CCC TCC GT (FRAG 954) (SEQ. ID NO: 964) 5'-GGT GGC TCC TCT GC (FRAG 955) (SEQ. ID NO: 965) 5'-GCT TGG TCC TGG GGC TGC (FRAG 956) (SEQ. ID NO: 966) 5'-TGC TCT CCr CTC CTT (FRAG 957) (SEQ. ID NO: 967) Human Adenosine A2a Receptor Nucleic Acid and Antisense Oligonucleotide Fragments 5'-TGC TI TCT TT CTG GGC CTC TGT GGT Cr6 TT TT TCT G GCC CTG CTG GGG CGC TCT CC GCC GCC CGC CTG GCT CCC GGB GCC CBT GBT GGG CBT GCC GTG GTT CTT GCC CTC CTT TGG CTG CCG TGC CCG CTC CCC GGC CTC CTG GCG GGT GGC CGT TG GGC CCG TGT TCC CCT GGG -GCC TGG GGC TCC CTT CTC TC GCC CTT CTT GCT GGG CCT C TGC TGC TGC TGG TGC TGT GGC CCC C GTA CAC CGA GGA GCC CAT GAT GGG CAT GCC ACA GAC GAC AGG C GTB CBC CGB GGB GCC CBT GBT GGG CBT GCC BCB GBC GBC BGG C-3' (FRAG. NO. 1665) (SEQ. ID NO:1678) 5'-CTG GGC CTC-3' (FRAG 1666) (SEQ. ID NO: 1679) WO 00/09525 PCT/US99/17712 EPI-109 101 5'-GCC GCC CGC CTG-3' (FRAG 1667) (SEQ. ID NO: 1680) 5'-GC CCG CTC CCC GGC-3' (FRAG 1668) (SEQ. ID NO: 1681) 5'-CBCCGBGGBGCCC-3' (FRAG 1669) (SEQ. ID NO: 1682) 5'-TGC TTT TCT TIT CTG GGC CTC-3' (FRAG 958) (SEQ. ID NO: 968) 5'-TGT GGT CTG TTT TT TCr G-3' (FRAG 959) (SEQ. ID NO: 969) 5'-GCC CTG CTG GGG CGC TCT CC-3' (FRAG 960) (SEQ. ID NO: 970) 5'-GCC GCC CGC CTG GCT CCC-3' (FRAG 961) (SEQ. ID NO: 971) 5'-GGB GCC CBT GBT GGG CBT GCC-3' (FRAG 962) (SEQ. ID NO: 972) 5'-GTG GTT CTT GCC C CTT TGG CrG-3' (FRAG 963) (SEQ. ID NO: 973) 5'-CCG TGC CCG CTC CCC GGC-3' (FRAG 964) (SEQ. ID NO: 974) 5'-CTC CTG GCG GGT GGC CGT TG-3' (FRAG 965) (SEQ. ID NO: 975) 5'-GGC CCG TGT TCC CCT GGG-3' (FRAG 966) (SEQ. ID NO: 976) 5'-GCC TGG GGC TCC CTT CTC TC-3' (FRAG 967) (SEQ. ID NO: 977) 5'-GCC CIT CIT GCT GGG CCT C-3 (FRAG 968) (SEQ. ID NO: 978) 5'-TGC TGC TGC TGG TGC TGT GGC CCC C-3' (FRAG 969) (SEQ. ID NO: 979) 5'-GTACACCGAGGAGCCCATGATGGGCATGCCACAGACGACAGGC-3' (FRAG 970) (SEQ. ID NO: 980) 5'-GTBCBCCGBGGBGCCCBTGBTGGGCBTGCCBCBGBcGBCBGGC-3' (FRAG 971) (SEQ. ID NO: 981) Human Adenosine A2b Receptor Nucleic Acid and Antisense Oligonucleotide Fra2ments 5'-GGC GCC GTG CCG CGT CTT GGT GGC GGC GG GTT CGC GCC CGC GCG GGG CCC CTC CGG TCC GTT CGC GCC CGC GCG GGG CCC CTC CGG TCC CGG GTC GGG GCC CCC CGC GGC C GCC TCG GGG CTG GGG CGC TGG TGG CCG GG CCG CGC CTC CGC CTG CCG CTT CTG GCT GGG CCC CGG GCG CCC CCT CCC CTC TrG CTC GGG TCC CCG TG ACA GCG CGT CCT GTG TCT CCA GCA GCA TGG CCG GGC CAG CTG GGC CCC BCB GCG CGT CCT GTG TCT CCB GCB GCB TGG CCG GGC CBG CTG GGC CCC CCCAGCCCCG AGGCTCAGAA GCGGCAGGCG GAGGCGCGGT CCGGGCGCTA TGGCCATGCC CGGCGGGTCT CACGCGGCTG CCCCTCGCCC GGCGCGCCTT CGGTAGGGGG CGCCCGGGGC CCAGCTGGCC CGGCCATGCT GCTGGAGACA CAGGACGCGC TGTACGTGGC GCTGGAGCTG GTCATCGCCG CGCTTCGGT GGCGGGCAAC GTGCTGGTGT GCGCCGCGGT GGGCACGGCG AACACTCTGC AGACGCCCAC CAACTACTTC CTGGTGTCCC TGGCTGCGGC CGACGTGGCC GTGGGGCTCT TCGCCATCCC CTTGCCATC ACCATCAGCC TGGGCTG CACTGACTC TACGGCTGCC TcrrCCTCGC CTGCTTCGTG CTGGTGCTCA CGCAGAGCTC CATCTTCAGC CTTCTGGCCG TGGCAGTCGA CAGATACCTG GCCATCTGTG TCCCGCTCAG GTATAAAAGT TrGGTCACGG GGACCCGAGC AAGAGGGGTC ATrGCTGTCC TCTGGGTCCT TGCCTTTGGC ATCGGATTGA CTCCATTCCT GGGGTGGAAC AGTAAAGACA GTGCCACCAA CAACTGCACA GAACCCTGGG ATGGAACCAC GAATGAAAGC TGCTGCCTTG TGAAGTGTCT CTTTGAGAAT GTGGTCCCCA TGAGCTACAT GGTATATTTC AAITCTTTG GGTGTGT7CT GCCCCCACTG CTTATAATGC TGGTGATCTA CATTAAGATC TTCCTGGTGG CCTGCAGGCA GCTCAGCGC ACTGAGCTGA TGGACCACTC GAGGACCACC CTCCAGCGGG AGATCCATGC AGCCAAGTCA CTGGCCATGA TTGTGGGGAT TTTTGCCCTG TGCTGGTTAC CTGTGCATGC TGTAACTGT GTCACTCTT TCCAGCCAGC TCAGGGTAAA AATAAGCCCA AGTGGGCAAT GAATATGGCC ATTCTTCTGT CACATGCCAA TTCAGTTGTC AATCCCATTG TCTATGCTTA CCGGAACCGA GACTTCCGCT ACACI i-CA CAAAATTATC TCCAGGTATC TTCrCTGCCA AGCAGATGTC AAGAGTGGGA ATGGTCAGGC TGGGGTACAG CCTGCTCTCG GTGTGGGCCT ATGATCTAGG CTCTCGCCTC TITCCAGGAGA AGATACAAAT CCACAAGAAA CAAAGAGGAC ACGGCTGGTT TTCATTGTGA AAGATAGCTA CACCTCACAA GGAAATGGAC TGCCrCTCTT GAGCACT'TCC CTGGAGCTAC CACGTATCTA GCTAATATGT ATGTGTCAGT AGTAGCACCA AGGATTGACA AATATATTTA TGATCTATTC AGCTGCIT1r ACTGTGTGGA TrATGCCAAC AGCTTGAATG GATTCTAACA GACTCT1-1G 7TiliAAAAG TCCCTTGT TTATGGTGGA AAATTACTGA AACTATTA CTGTGAAACA GTGTGAACTA TTATAATGCA AATACITI1- AACTTAGAGG CAATGGAAAA ATAAAAGITG ACTGTACTAA AAATGTATAC TTGTTGCCAG GAAGGTGACC TCAAAAATTA AAAGTATAAT TATrCGGCCG GGCATGGTGG CTCACACCTG TAATTCCAGC ACTTTGGGAG GCCAAGGCAG GCGGATCACG AGGTCAGGAG TTCAAAACCA GCCTGTCCAA TATAGTG GGGCAATTTG TTAGTTATCC GCCGCCACCA AGACGCGGCA CGGCGCCTGG ACCGGAGGGG CCCCGCGCGG GCGCGAACTr TGGGCTCGGG CGAGTGGGTG GTGCTCCGCC CAGCCCGAGA CGGGCGGGCG CGCGGGCCAA TGGGTGCCGC CTCTGGCCG CGGGGGGCCC CGACCCGTGG GTCCCGGCCA CCAGCGCCCC AGCCCCGAGG CTCAGAAGCG GCAGGCGGAG GCGCGGTCCG GGCGCTATGG CCATGCCCGG CGGGTCTCAC GCGGCTGCCC CTCGCCCGGC GCGCCTTCGG TAGGGGGCGC CCGGGGCCCA GCTGGCCCGG CCATGCTGCT GGAGACACAG GACGCGCTGT ACGTGGCGCT GGAGCTGGTC ATCGCCGCGC TTrCGGTGGC GGGCAACGTG CTGGTGTGCG CCGCGGTGGG CACGGCGAAC ACTCTGCAGA CGCCCACCAA CTACTrCCTG GTGTCCCTGG CTGCGGCCGA CGTGGCCGTG GGGCTCTrCG CCATCCCCTr TGCCATCACC ATCAGCCTGG GCrrCTGCAC TGACTrAC GGCTGCCTCr TCCTCGCCTG CrTCGTGCTG GTGCTCACGC AGAGCTCCAT CTTCAGCCTT CTGGCCGTGG CAGTCGACAG ATACCTGGCC ATCTGTGTCC CGCrCAGGTA TAAAAGTITTG GTCACGGGGA CCCGAGCAAG AGGGGTCATT GCTGTCCTCT GGGTCCTTGC CTTTGGCATC GGATTGACTC CATCCTGGG GTGGAACAGT AAAGACAGTG CCACCAACAA CTGCACAGAA CCCTGGGATG GAACCACGAA TGAAAGCTGC TGCCTTGTGA AGTGTCTCTT TGAGAATGTG GTCCCCATGA GCTACATGGT ATATCAAT TTCTTGGGT GTGTTCTGCC CCCACTGCTT ATAATGCTGG TGATCTACAT TAAGATC1TC CTGGTGGCCT GCAGGCAGCT TCAGCGCACT GAGCTGATGG ACCACTCGAG GACCACCCTC CAGCGGGAGA TCCATGCAGC CAAGTCACTG GCCATGATTG TGGGGATT1TT TGCCCrGTGC TGGTTACCTG TGCATGCTGT TAACTGTGTC ACTT1TCC AGCCAGCTCA GGGTAAAAAT AAGCCCAAGT GGGCAATGAA TATGGCCATT CTTCTGTCAC ATGCCAATTC AGTTGTCAAT CCCATTGTCT ATGCTTACCG GAACCGAGAC TTCCGCTACA CIT-CACAA AATrATCTCC AGGTATCTTC TCTGCCAAGC AGATGTCAAG AGTGGGAATG GTCAGGCTGG GGTACAGCCT GCTCrCGGTG TGGGCCTATG ATCTAGGCTC TCGCCrCTTC CAGGAGAAGA TACAAATCCA CAAGAAACAA AGAGGACACG GCTGGTTTTC ATTGTGAAAG ATAGCTACAC CTCACAAGGA AATGGACTGC CTCTCTTGAG CACTrCCCTG GAGCTACCAC GTATCTAGCT AATATGTATG TGTCAGTAGT AGGCrCCAAG GATTGACAAA TATAT'TATG ATCTATTCAG CTGCTTTTAC TGTGTGGATT ATGCCAACAG CTTGAATGGA TrCTAACAGA CTCIT1TGT TTTAAAAGTC TGCCTTGTTT ATGGTGGAAA ATTACTGAAA CTArTTTACT GTGAAACAGT GTGAACTArT ATAATGCAAA TACITITAA CTTAGAGGCA ATGGAAAAAT AAAAGTTGAC TGTACTAAAA WO 00/09525 PCTIUS99/1 7712 EPI-109 102 ATG CCCAGCCCCG AGGCTCAGAA GCGGCAGGCG GAGGCGCGGT CCGGGCGCTA TGGCCATGCC CGGCGGGTCT CACGCGGCTG CCCCTCGCCC GGCGCGC=r CGGTAGGGGG CGCCCGGGGC CCAGCTGGCC CGGCCATGCT GCTGGAGACA CAGGACGCGC TGTACGTGGC GCTGGAGCTG GTCATCGCCG CGC'IrCGGT GGCGGGCAAC GTGCTGGTGT GCGCCGCGGT GGGCACGGCG AACACTCTGC AGACGCCCAC CAACTACMC CTGGTGTCCC TGGCTGCGGC CGACGTGGCC GTGGGGCTCT TCGCCATCCC C'TIGCCATC ACCATCAGCC TGGGCTrCTG CACTGACTTC TACGGCTGCC TCTTCCTCGC CTGCTTCGTG CTGGTGCTCA CGCAGAGCTC CATCTrCAGC =TCTGGCCG TGGCAGTCGA CAGATACCTG GCCATCTGTG TCCCGCTCAG GTATAAAAGT 7-rGGTCACGG GGACCCGAGC AAGAGGGGTC A'ITGCTGTCC TCTGGGTCCT TGCCIT1GGC ATCGGArrGA C7CCATTCCT GGGGTGGAAC AGTAAAGACA GTGCCACCAA CAACTGCACA GAACCCTGGG ATGGAACCAC GAATGAAAGC TGCTGCCT'TG TGAAGTGTCT =TTGAGAAT GTGGTCCCCA TGAGCTACAT GGTATMT7C AATrrITrG GGTGTGTTCT GCCCCCACTG CTTATAATGC TGGTGATCTA CATTAAGATC TFTCCTGGTGG CCTGCAGGCA GCTCAGCGC ACTGAGCTGA TGGACCACTC GAGGACCACC CTCCAGCGGG AGATCCATGC AGCCAAGTCA CTGGCCATGA TTGTGGGGAT TITGCCC7G TGCTGGTTAC CTGTGCATGC TGTrAACTGT GTCACTCTI TCCAGCCAGC TCAGGGTAAA AATAAGCCCA AGTGGGCAAT GAATATGGCC ATTCTTCTGT CACATGCCAA T7CAGTTGTC AATCCCATTG TCTATGC117A CCGGAACCGA GACTITCCGCT ACACT1TCA CAAAATTATC TCCAGGTATC TTCTCTGCCA AGCAGATGTC AAGAGTGGc3A ATGGTCAGGC TGGGGTACAG CCTGCTCTCG GTGTGGGCCT ATGATCTAGG CTCTCGCCTC TrCCAGGAGA AGATACAAAT CCACAAGAAA CAAAGAGGAC ACGGCTGG'17 rrCATTGTGA AAGATAGCTA CACCTCACAA GGAAATGGAC TGCCTCTrCTT GAGCACT-rCC CTGGAGCTAC CACGTATCTA GCTAATATGT ATGTGTCAGT AGTAGCACCA AGGATTGACA AATATA TTA TGATCTATTC AGCTGC'I= ACTGTGTGGA TTATGCCAAC AG=fGAATG GATTrAACA GACT~TITG 'TITAAAAG TCTGCCTrGT TTATGGTGGA AAA7FACTGA AACTATITA CTGTGAAACA GTGTGAACTA 'ITATAATGCA AATACrrP AACTrAGAGG CAATGGAAAA ATAAAAGT-rG ACTGTACTAA AAATGTATAC TTGflGCCAG GAAGGTGACC TCAAAAATrA AAAGTATAAT TATTCGGCCG GGCATGGTGG CTCACACCTG TAATTCCAGC ACTTGGGAG GCCAAGGCAG GCGGATCACG AGGTCAGGAG FTCAAAACCA GCCTGTCCAA TATAGTG GGGCAAM~G 'FrAGTrATCC GCCGCCACCA AGACGCGGCA CGGCGCCTGG ACCGGAGGGG CCCCGCGCGG GCGCGAACT TGGGCTCGGG CGAGTGGGTG GTGCTCCGCC CAGCCCGAGA CGGGCGGGCG CG3CGGGCCAA TGGGTGCCGC CTC'rrGGCCG CGGGGGGCCC CGACCCGTGG GTCCCGGCCA CCAGCGCCCC AGCCCCGAGG CTCAGAAGCG GCAGGCGGAG GCGCGGTCCG GGCGCTATGG CCATGCCCGG CGGGTCTCAC GCGGCTGCCC CTCGCCCGGC GCGC=TCGG TAGGGGGCGC CCGGGGCCCA GCTGGCCCGG CCATGCTGCT GGAGACACAG GACGCGCTGT ACGTGGCGCT GGAGCTGGTC ATCGCCGCGC 7FrTCGGTGGC GGGCAACGTG CTGGTGTGCG CCGCGGTGGG CACGGCGAAC ACTCTGCAGA CGCCCACCAA CTACTCCTG GTGTCCCTGG CTGCGGCCGA CGTGGCCGTG GGGCTCTTCG CCATCCCCFI TGCCATCACC ATCAGCCTGG GCrGCAC TGACTTCTAC GGCTGCCTCT TCCTCGCCTG CTrCGTGCTG GTGCTCACGC AGAGCTCCAT C'FCAGCCr CTGGCCGTGG CAGTCGACAG ATACCTGGCC ATCTGTGTCC CGCTCAGGTA TAAAAGMrfG GTCACGGGGA CCCGAGCAAG AGGGGTCATT GCTGTCCTCT GGGTCCTIGC CTT=GGCATC GGATrGACTC CATTCCTGGG GTGGAACAGT AAAGACAGTG CCACCAACAA CTGCACAGAA CCCTGGGATG GAACCACGAA TGAAAGCTGC TGCCTTGTGA AGTGTCTcrr TGAGAATGTG GTCCCCATGA GCTACATGGT ATA'TrTCAAT T~T=GGGT GTGTrCTGCC CCCACTGCTr ATAATGCTGG TGATCTACAT TAAGATCTTC CTGGTGGCCT GCAGGCAGCT TCAGCGCACr GAGCTFGATGG ACCACTCGAG GACCACCCTC CAGCGGGAGA TCCATGCAGC CAAGTCACTG GCCATGATrG TGGGGA7TT TGCCCTGTGC TGG TrACCTG TGCATGCTGT TAACTGTGTC ACrCTITCC AGCCAGCTCA GGGTAAAAAT AAGCCCAAGT GGGCAATGAA TATGGCCATr C'ICTGTCAC ATGCCAAUrC AGTTGTCAAT CCCATTGTCT ATGCMACCG GAACCGAGAC TTCCGCTACA CTITCACAA AATTATCTCC AGGTATCTTC TCTGCCAAGC AGATGTCAAG AGTGGGAATG GTCAGGCTGG GGTACAGCCT GCrCTCGGTG TGGGCCTATG ATCTAGGCTC TCGCCT=TC CAGGAGAAGA TACAAATCCA CAAGAAACAA AGAGGACACG GCTGGTITC ATrGTGAAAcI ATAGCTACAC CTCACAAGGA AATGGACTGC C7CTCTFGAG CACTCCCTG GAGCTACCAC GTATCTAGCT AATATGTATG TGTCAGTAGT AGGCTCCAAG GATrGACAAA TATA=TATG ATCTATI'CAG CTGCT1TAC TGTGTGGAT7 ATGCCAACAG CTTGAATGGA rCTAACAGA CTCrrrT' ITAAAAGTC TGCCTTG'I-r ATGGTGGAAA ATTACTGAAA CTATITACT GTGAAACAGT GTGAACTAT7 ATAATGCAAA TACTI=AA =TAGAGGCA ATGGAAAAAT AAAAG F7GAC TGTACTAAAA ATG -3- (FRAG. NO: 1670) (SEQ. ID NO:1683) 5'- GGGCAA'IMG T1-AGT7ATCC GCCGCCACCA AGACGCGGCA CGGCGCCTGG ACCGGAGGGG CCCCGCGCGG GCGCGAACT TGGGCTCGG3G CGAGTGGGTG GTGCTCCGCC CAGCCCGAGA CGGGCGGGCG CGCGGGCCAA TGGGTGCCGC CTCITGGCCG CGGGGGGCCC CGACCCGTGG GTCCCGGCCA CCAGCGCCCC AGCCCCGAGG CTCAGAAGCG GCAGGCGGAG GCGCGGTCCG GGCGCTATGG CCATGCCCGG CGGGTCTCAC GCGGCTGCCC CTCGCCCGGC GCGCCTITCGG TAGGGGGCGC CCGGGGCCCA GCTGGCCCGG CCATGCTGCT GGAGACACAG GACGCGCTGT ACGTGGCGCT GGAGCTGGTC ATCGCCGCGC F~rCGGTGGC GGGCAACGTG CTGGTGTGCG CCGCGGTGGG CACGGCGAAC ACTGTGCAGA CGCCCACCAA CTACTTCCTG GTGTCCCrGG CTGCGGCCGA CGTGGCCGTG GGGCTCTTCG CCATCCC=r TGCCATCACC ATCAGCCTGG GCT-FCTGCAC TGACTTrCTAC GGCTGCCTCT TCCTCGCCTG CTTCGTGCTG GTGCTCACGC AGAGCTCCAT CTITCAGCCTT CTGGCCGTGG CAGTCGACAG ATACCTGGCC ATCTGTGTCC CGCTCAGGTA TAAAAG'ITG GTCACGGGGA CCCGAGCAAG AGGGGTCAT7 GCrGTCCTCT GGGTCCTTGC CITGGCATC GGATTGACTC CATTCCTGGG GTGGAACAGT AAAGACAGTG CCACCAACAA CTGCACAGAA CCCTGGGATG GAACCACGAA TGAAAGCTGC TGCCTrGTGA AGTGTCTCTI TGAGAATGTG GTCCCCATGA GCTACATGGT ATATI17CAAT 'I1CI=GGGT GTGTTCTGCC CCCACTGCTT ATAATGCTGG TGATCTACAT TAAGATCTrC CTGGTGGCCT GCAGGCAGCT TCAGCGCACT GAGCTGATGG ACCACTCGAG GACCACCCTC CAGCGGGAGA TCCATGCAGC CAAGTCACTG GCCATGATTrG TGGGGA'Ir TGCCCTGTGC TGGTTACCTG TGCATGCTGT TAACTGTGTC ACTCTITCC AGCCAGCTCA GGGTAAAAAT AAGCCCAAGT GGGCAATGAA TATGGCCATT CTGTCAC ATGCCAATITC AGTITGTCAAT CCCATrGTCT ATGCTTACCG GAACCGAGAC TTCCGCTACA CTITCACAA AAflATCTCC AGGTATCT7C TCTGCCAAGC AGATGTCAAG AGTGGGAATG GTCAGGCTGG GGTACAGCC7 GCTCTCGGTG TGGGCCTATG ATCTAGGCTC TCGCCTCTTC CAGGAGAAGA TACAAATCCA CAAGAAACAA AGAGGACACG GCTGGT1TC AT7GTGAAAG ATAGCrACAC CTCACAAGGA AATGGACTGC CTCTCTTGAG CACTI'CCCTG GAGCTACCAC GTATCTAGCT AATATGTATG TGTCAGTAGT AGGCTCCAAG GATrGACAAA TATA'IMATG ATCTATrCAG CTGCI=rAC TGTGTGGATT ATGCCAACAG CTrGAATGGA TTCTAACAGA CTrCITGTT TTTAAAAGTC TGCCTGM7 ATGGTGGAAA ATITACTGAAA CTATITACT GTGAAACAGT GTGAACrT F ATAATGCAAA TAC1TITAA CTFAGAGGCA ATGGAAAAAT AAAAG ITGAC TGTACTAAAA ATG -3' (FRAG. NO:_) (SEQ. ID WO 00/09525 PCT/US99/17712 EPI-109 103 NO:2436) 5'- CCCAGCCCCG AGGCTCAGAA GCGGCAGGCG GAGGCGCGGT CCGGGCGCTA TGGCCATGCC CGGCGGGTCT CACGCGGCTG CCCCTCGCCC GGCGCGCCTT CGGTAGGGGG CGCCCGGGGC CCAGCTGGCC CGGCCATGCT GCTGGAGACA CAGGACGCGC TGTACGTGGC GCTGGAGCTG GTCATCGCCG CGCTTTCGGT GGCGGGCAAC GTGCTGGTGT GCGCCGCGGT GGGCACGGCG AACACTCTGC AGACGCCCAC CAACTACTTC CTGGTGTCCC TGGCTGCGGC CGACGTGGCC GTGGGGCTCT TCGCCATCCC CTTTGCCATC ACCATCAGCC TGGGCTTCTG CACTGACTTC TACGGCTGCC TCTTCCTCGC CTGCTTCGTG CTGGTGCTCA CGCAGAGCTC CATCTTCAGC CTTCTGGCCG TGGCAGTCGA CAGATACCTG GCCATCTGTG TCCCGCTCAG GTATAAAAGT TTGGTCACGG GGACCCGAGC AAGAGGGGTC ATTGCTGTCC TCTGGGTCCT TGCC=GGC ATCGGATTGA CTCCATTCCT GGGGTGGAAC AGTAAAGACA GTGCCACCAA CAACTGCACA GAACCCTGGG ATGGAACCAC GAATGAAAGC TGCTGCCTTG TGAAGTGTCT CTGAGAAT GTGGTCCCCA TGAGCTACAT GGTATATTTC AA=TTC G GGTGTGTrCT GCCCCCACTG CTTATAATGC TGGTGATCTA CATTAAGATC TTCCTGGTGG CCTGCAGGCA GCTTCAGCGC ACTGAGCTGA TGGACCACTC GAGGACCACC CTCCAGCGGG AGATCCATGC AGCCAAGTCA CTGGCCATGA TTGTGGGGAT TTTTGCCCTG TGCTGGTTAC CTGTGCATGC TGTTAACTGT GTCACTC1 TCCAGCCAGC TCAGGGTAAA AATAAGCCCA AGTGGGCAAT GAATATGGCC ATTCTTCTGT CACATGCCAA TTCAGTTGTC AATCCCATTG TCTATGCTTA CCGGAACCGA GACTTCCGCT ACACTiliCA CAAAATTATC TCCAGGTATC TrCTCTGCCA AGCAGATGTC AAGAGTGGGA ATGGTCAGGC TGGGGTACAG CCTGCTCTCG GTGTGGGCCT ATGATCTAGG CTCTCGCCTC TrCCAGGAGA AGATACAAAT CCACAAGAAA CAAAGAGGAC ACGGCTGGTT TTCATTGTGA AAGATAGCTA CACCTCACAA GGAAATGGAC TGCCTCTCTT GAGCACTTCC CTGGAGCTAC CACGTATCTA GCTAATATGT ATGTGTCAGT AGTAGCACCA AGGATTGACA AATATA'TA TGATCTATTC AGCTGCTT ACTGTGTGGA TTATGCCAAC AGCTTGAATG GATTCTAACA GACTCI iiG TTAAAAG TCTGCCTTGT TrATGGTGGA AAATTACTGA AACTATTITA CTGTGAAACA GTGTGAACTA TTATAATGCA AATAC'IT11I AACTTAGAGG CAATGGAAAA ATAAAAGTTG ACTGTACTAA AAATGTATAC TrGrGCCAG GAAGGTGACC TCAAAAATTA AAAGTATAAT TATTCGGCCG GGCATGGTGG CTCACACCTG TAATrCCAGC ACTTTGGGAG GCCAAGGCAG GCGGATCACG AGGTCAGGAG TTCAAAACCA GCCTGTCCAA TATAGTG -3' (FRAG. NO:_) (SEQ. ID NO:2435) 5'- GGGCAATTTG TrAGTrATCC GCCGCCACCA AGACGCGGCA CGGCGCCTGG ACCGGAGGGG CCCCGCGCGG GCGCGAACTT TGGGCTCGGG CGAGTGGGTG GTGCTCCGCC CAGCCCGAGA CGGGCGGGCG CGCGGGCCAA TGGGTGCCGC CTCTTGGCCG CGGGGGGCCC CGACCCGTGG GTCCCGGCCA CCAGCGCCCC AGCCCCGAGG CTCAGAAGCG GCAGGCGGAG GCGCGGTCCG GGCGCTATGG CCATGCCCGG CGGGTCTCAC GCGGCTGCCC CTCGCCCGGC GCGCCTTCGG TAGGGGGCGC CCGGGGCCCA GCTGGCCCGG CCATGCTGCT GGAGACACAG GACGCGCTGT ACGTGGCGCT GGAGCTGGTC ATCGCCGCGC TTTCGGTGGC GGGCAACGTG CTGGTGTGCG CCGCGGTGGG CACGGCGAAC ACTCTGCAGA CGCCCACCAA CTACTTCCTG GTGTCCCTGG CTGCGGCCGA CGTGGCCGTG GGGCTCTTCG CCATCCCCTT TGCCATCACC ATCAGCCTGG GCTTCTGCAC TGACTTCTAC GGCTGCCTCT TCCTCGCCTG CT7CGTGCTG GTGCTCACGC AGAGCTCCAT CTTCAGCCTT CTGGCCGTGG CAGTCGACAG ATACCTGGCC ATCTGTGTCC CGCTCAGGTA TAAAAGTTTG GTCACGGGGA CCCGAGCAAG AGGGGTCATT GCTGTCCTCT GGGTCCTTGC CTTTGGCATC GGATTGACTC CATTCCTGGG GTGGAACAGT AAAGACAGTG CCACCAACAA CTGCACAGAA CCCTGGGATG GAACCACGAA TGAAAGCTGC TGCCTTGTGA AGTGTCTCTT TGAGAATGTG GTCCCCATGA GCTACATGGT ATAITCAAT TTCITGGGT GTG'TTCTGCC CCCACTGCTT ATAATGCTGG TGATCTACAT TAAGATCTTC CTGGTGGCCT GCAGGCAGCT TCAGCGCACT GAGCTGATGG ACCACTCGAG GACCACCCTC CAGCGGGAGA TCCATGCAGC CAAGTCACTG GCCATGATTG TGGGGATTI TGCCCTGTGC TGGTTACCTG TGCATGCTGT TAACTGTGTC ACTCTTTTCC AGCCAGCTCA GGGTAAAAAT AAGCCCAAGT GGGCAATGAA TATGGCCATT CTTCTGTCAC ATGCCAATTC AGTTGTCAAT CCCATTGTCT ATGCTTACCG GAACCGAGAC TTCCGCTACA C7I-rCACAA AATTATCTCC AGGTATCTTC TCTGCCAAGC AGATGTCAAG AGTGGGAATG GTCAGGCTGG GGTACAGCCT GCTCTCGGTG TGGGCCTATG ATCTAGGCTC TCGCCTCTTC CAGGAGAAGA TACAAATCCA CAAGAAACAA AGAGGACACG GCTGGTITTC ATTGTGAAAG ATAGCTACAC CTCACAAGGA AATGGACTGC CTCTCTTGAG CACTTCCCTG GAGCTACCAC GTATCTAGCT AATATGTATG TGTCAGTAGT AGGCTCCAAG GATTGACAAA TATATATG ATCTATTCAG CTGCUTITAC TGTGTGGATT ATGCCAACAG CTTGAATGGA TrCTAACAGA CTC-TG'TT TTAAAAGTC TGCCTTGT ATGGTGGAAA ATTACTGAAA CTATITTACT GTGAAACAGT GTGAACTATT ATAATGCAAA TACTITrAA CTTAGAGGCA ATGGAAAAAT AAAAGTTGAC TGTACTAAAA ATG -3' (FRAG. NO:_) (SEQ. ID NO:2425) 5'-CCCAGCCCCG AGGCTCAGAA GCGGCAGGCG GAGGCGCGGT CCGGGCGCTA TGGCCATGCC CGGCGGGTCT CACGCGGCTG CCCCTCGCCC GGCGCGCCTT CGGTAGGGGG CGCCCGGGGC CCAGCTGGCC CGGCCATGCT GCTGGAGACA CAGGACGCGC TGTACGTGGC GCTGGAGCTG GTCATCGCCG CGCTCGGT GGCGGGCAAC GTGCTGGTGT GCGCCGCGGT GGGCACGGCG AACACTCTGC AGACGCCCAC CAACTACTTC CTGGTGTCCC TGGCTGCGGC CGACGTGGCC GTGGGGCTCT TCGCCATCCC CTTGCCATC ACCATCAGCC TGGGCTTCTG CACTGACTTC TACGGCTGCC TCTTCCTCGC CTGCTTCGTG CTGGTGCTCA CGCAGAGCTC CATCTTCAGC CTTCTGGCCG TGGCAGTCGA CAGATACCTG GCCATCTGTG TCCCGCTCAG GTATAAAAGT TTGGTCACGG GGACCCGAGC AAGAGGGGTC ATTGCTGTCC TCTGGGTCCT TGCC1TiGGC ATCGGATTGA CTCCATTCCT GGGGTGGAAC AGTAAAGACA GTGCCACCAA CAACTGCACA GAACCCTGGG ATGGAACCAC GAATGAAAGC TGCTGCCTTG TGAAGTGTCT CTGAGAAT GTGGTCCCCA TGAGCTACAT GGTATATC AATTCTTTG GGTGTGTTCT GCCCCCACTG CTTATAATGC TGGTGATCTA CATTAAGATC TTCCTGGTGG CCTGCAGGCA GCTTCAGCGC ACTGAGCTGA TGGACCACTC GAGGACCACC CTCCAGCGGG AGATCCATGC AGCCAAGTCA CTGGCCATGA TTGTGGGGAT TTITGCCCTG TGCTGGTrAC CTGTGCATGC TGTrAACTGT GTCACTCTTT TCCAGCCAGC TCAGGGTAAA AATAAGCCCA AGTGGGCAAT GAATATGGCC ATTCTTCTGT CACATGCCAA TTCAGTTGTC AATCCCATTG TCTATGCTTA CCGGAACCGA GAC1TTCCGCT ACACTil1CA CAAAATTATC TCCAGGTATC rCTCTGCCA AGCAGATGTC AAGAGTGGGA ATGGTCAGGC TGGGGTACAG CCTGCTCTCG GTGTGGGCCT ATGATCTAGG CTCTCGCCTC TTCCAGGAGA AGATACAAAT CCACAAGAAA CAAAGAGGAC ACGGCTGGTT TTCATrGTGA AAGATAGCTA CACCTCACAA GGAAATGGAC TGCCTCrCTr GAGCACTTCC CTGGAGCTAC CACGTATCTA GCTAATATGT ATGTGTCAGT AGTAGCACCA AGGATTGACA AATATATT7A TGATCTATTC AGCTGCTTTT ACTGTGTGGA TTATGCCAAC AGCTTGAATG GATTCTAACA GACTCT11G TTIAAAAG TCTGCCTTGT TTATGGTGGA AAATrACTGA AACTATTTTA CTGTGAAACA GTGTGAACTA TTATAATGCA AATAC1II1T AACTAGAGG CAATGGAAAA ATAAAAGTTG ACTGTACTAA AAATGTATAC TTGT7TGCCAG GAAGGTGACC TCAAAAATTA AAAGTATAAT TATTCGGCCG WO 00/09525 PCT/US99/17712 EPI-109 104 GGCATGGTGG CTCACACCTG TAATTCCAGC ACTTGGGAG GCCAAGGCAG GCGGATCACG AGGTCAGGAG TTCAAAACCA GCCTGTCCAA TATAGTG (FRAG. NO: _) (SEQ. ID NO: 2424) 5'-GCGCGTCCTG-3' (FRAG. NO: 1671) (SEQ. ID NO:1684) 5'-GCT GGG CCC CGG-3' (FRAG. NO: 1672) (SEQ. ID NO:1685) 5'-CGG GTC GGG GCC CCC C-3' (FRAG. NO: 1673) (SEQ. ID NO:1686) 5'- CGC GCC CGC G-3' (FRAG. NO: 1674) (SEQ. ID NO:1687) 5'-GGC GCC GTG CCG CGT CM GGT GGC GGC GG-3' (FRAG 972) (SEQ. ID NO: 982) 5'-GTr CGC GCC CGC GCG GGG CCC CTC CGG TCC-3' (FRAG 973) (SEQ. ID NO: 983) 5'-GTT CGC GCC CGC GCG GGG CCC CTC CGG TCC-3' (FRAG 974) (SEQ. ID NO: 984) 5'-CGG GTC GGG GCC CCC CGC GGC C-3' (FRAG 975) (SEQ. ID NO: 985) 5'-GCC TCG GGG CTG GGG CGC TGG TGG CCG GG-3' (FRAG 976) (SEQ. ID NO: 986) 5'-CCG CGC CTC CGC CTG CCG CTT CTG-3' (FRAG 977) (SEQ. ID NO: 987) 5'-GCT GGG CCC CGG GCG CCC CCT-3' (FRAG 978) (SEQ. ID NO: 988) 5'-CCC CTC TTG CTC GGG TCC CCG TG-3' (FRAG 979) (SEQ. ID NO: 989) 5'-ACAGCGCGTCCTGTGTCTCCAGCAGCATGGCCGGGCCAGCTGGGCCCC-3' (FRAG 980) (SEQ. ID NO: 990) 5'-BCBGCGCGTCCTGTGTCTCCBGCBGCBTGGCCGGGCCBGCTGGGCCCC-3' (FRAG 981) (SEQ. ID NO: 991) Human Adenosine A3 Receptor Nucleic Acid and Antisense Oligonucleotide Fragments 5'-ACA GAG CAG TGC TGT TGT TGG GCA TCT TGC CTT CCC AGG G BCB GBG CB TGC TGT TGT TGG GCB TCT TGC CTr CCC BGG GCC CTT TTC TGG TGG GGT GOT GCT GTT GTT GGG CTT TCT TCT GT CCC BCB GBG CBG TGC TGT TGT TGG GCB TCT TGC CT CCC BGG GCC CIT TTC TGG TGG GGT GOT GCT GTT GTT GGG C TT CTT CTG TTC CC GAATTCCCAG ATGGGCAGAG GTGGCTGGGC TGGTGACCCT AAGTGTGTCT CCTGCCTA TTCTCTCTAG TGGGTTATTC TTTCATGTGG TATCTTGCCT ACAGCATGCT GTGTTGGAC ACAAACCCCT TTCCTTGGTr TCTCTGACCC AGCTGAGATG GACTGATTCC AAAAGAACTC ACCTATGTAC TGGGGTAGGG GAGGGAGGGT 7ITI GCAGT ATTTAACTAA GGTTCAAAGA GTGCTATATA GTGAGAAAGG CTTT=r T-FITITFi i I rOGGCA GAGTGCTGCC TCCTAGAAAT TrCTCTTGGT AAC'TTCCFTC TCTGAAGCAC AGATAAAGAA AACAATTACA GTAGAAACAT TTATGAGGGA CACATTGGAG GCCGATGAAG CTITTCAAGT TCCAGCAGTG CAGGGATGTG GGCAGAACTG ACATTGGAAA ATACTAGAAT GATGGAAATT CAGTTGGAGA GGACTGCCCT T=TAATGTC TGGGGAGTCT GCTCAGGGAG AAATGACAAG TCTGGCGGGG ACAAGTATGG GATTGGTAA GACTTGGATC AACTrGGGAT ACAGGGTGGG GGTCGGGAGT GGAATCAATG AATGATGCCA GAGCAGATCA ACTAACAAGA GGACCCTGAT GAGCCCCAGG CAGAGGCGTC TCCCTTATGC CCCACTCTGA AGTGTTGTT AGTAAACACC AGAACGCCAT TGTTGTTACT GCTGAATT ATTGGGCT GTACATATTT AGATGCTTAA GGTAAAAATG ATAAAGCCCT CAAGCCACTG TGTGGGTTG GGTCCAAGTG TTCCTTCTTG CTGCCTCTCT AACACGCCTG GTTAAAATAA TCCCGTGA TGGTGCTGAG AAGCACCTGA ACCAAGTGGG TCCCCAAATA ACAATGGCGT GCAAGTGTCT GGTTCCCAGA AGTTGGTGAC TAGGTAAGCA GCTTCAGGGA GAGGGGGCTG ATTCCCAGAC AGTCGCCTGT TCCTGCGGGG ATGGGGCTGA GGCTTGGGGA ATGTGGGCAG GAGGATATGC CATTTGATTC TGTrGCACAC GTTC ITTCC CTTCTTTCTG TATGTCTGGT CATTCTGCTA TTCTGTCGTT CCTCACATAG GTTGGACATT GGCCGGCTGC CAGCATAAGT GCCAGTGTGA TTTGCTAGG TGTGAGCTGA GAAAGAGAGG TGGAGGCTAA GCAGGTGTGA TGCTTCTCAG AGGTGCTGAG 1TrIGCCCT TCTGAGCAGG GAATCGTTTC TTATCCCT GACCAAGGAT CTTGCTGCA AAGGCTGGGT ATCGGCTGTG CTCAGCAAAG CGTCAACTCG TGCAAGAACT TAGCAGGAAT AGTTCTGGCT AAGGTTAGGA GGCTGCCACC AAAGTCTCTT TTGTTCCT CTGCTTCTCC CG'TTTGCCTC CTTATCATGA GATCTITFMG CTAAGCTGGC AGAAAGATTG CATAGTCAGT GCTTCCAGCT CTGCTCCCAC CTGATCCTGC ACTGTCCTCT GGTCCCTGAA TGAATGAACT CTGATACCCA ATCTTGTCTC GAGCCTTCTC TATGCCACTC ATGGCTCCTC TTCTGCTCTT TCCATCT1TT TGCTGAGAGT TCTGAGCTCT GTACTCCTC TTGGCCCATC TCACTTCCTG AAACACCCCT GAAGAGGGTT GCTTATCTTG ATGGAACTCA AAAAGCCAAA AAGCTGCAGG CAGAGGCGTT GAGGACATCT GTTGGGGAA CTAAGAGCAG CAGCACTTTC AGATTCAGTC CATATAGAGC TGTCCTACAG CATTCTGGAA ACTTGAGGAT GTGCGGTGCA TAAAGGGGCT GGAAGTGACC CACCTGTGAT GAGCCCTITC TAAGGAGAAG GGTTTCCAAG AGATCACCCC ACCAGAAAAG GGTAGGAATG AGCAAGTTGG GAATTTTAGA CTGTCACTGC ACATGGACCT CTGGGAAGAC GTCTGGCGAG AGCTAGGCCC ACTGGCCCTA CAGACGGATC TTGCTGGCTC ACCTGTCCCT GTGGAGGTTC CCCTGGGAAG GCAAGATGCC CAACAACAGC ACTGCTCTGT CATTGGCCAA TGTTACCTAC ATCACCATGG AAA'TTTCAT TGGACTCTGC GCCATAGTGG GCAACGTGCT GGTCATCTGC GTGGTCAAGC TGAACCCCAG CCTGCAGACC ACCACCrrCT ATCATTGT CTCTCTAGCC CTGGCTGACA TTGCTGTTGG GGTGCTGGTC ATGCCTITGG CCATTGTTGT CAGCCTGGGC ATCACAATCC ACTTCTACAG CTGCCTIr ATGACTTGCC TACTGCTTAT CITACCCAC GCCTCCATCA TGTCCTTGCT GGCCATCGCT GTGGACCGAT ACTTGCGGGT CAAGCTTACC GTCAGGTAGC CTGCGGCGTG GGGTGGGCAG CAATTGAGGC AGCTGGGAAA TGAGGCTACA AAGCCAGAGC CTGCTGAATT TTATITTGGA CTGTACATAT TTAGATGC=T AAGGTAAAAA TGATAAAGCC CTCAAGCCAC TGTGTGGGTT GGGTCCAAGT GT'TCCTrGCT GCTGCCTCTC TAACACGCCT GGTTAAAATA ATCCCTTGG ATGGTGCTGA GAAGCACCTG AACCAAGTGG GTCCCCAAAT AACTATGGCG TGCAAGTGTC TGGTTCCCAG AAGTTGGTGA CTAGGTAAGC GACTCAGGGA GAGGGGCTGA TTCCCAGACA GTCGCCTGTT CCTGCTGGGA TGGGGCTGAG GCTTGGGGAA TGTGGGCAGG AGGATATGCC ATTTGATTCT GTTGCACACG TTCTITTCCC TTCTTTCTGT ATGTCTGGTC ATTCTGCTAT TCTGTCGTTC CTCACATAGG TTGGACATTG GCCGGCTGCC AGCATAAGTG CCAGTGTGAT TTTGCTAGGG TGTGAGCTGA GAAAGAGAGG TGGAGGCTAA GCAGGTGTGA TGCTTCTCAG AGGTGCTGAG ITITrGCCCT TCTGAGCAGG GAATCTTTGC TTATCCCTTT GACCAAGGAT CTTTGCTCCA AAGGCTGGGT ATCGGCTGTG CTCAGCAAAG CGTCAACTCG TGCAAGAACT TAGCAGGAAT AGTTCTGGCT AAGGTTAGGA GGCTGCCACC AAAGTCTCT ITTGTTCCT CTGCTTCTCC CGTTTGCCTC CTTATCATGA GATCITITrG CTAAGCTGGC AGAAAGATTG CATAATCAGT GCTTCCAGCT CCGCTCCCAC CTGATCCTGC ACTGTCCTCT GGTCCCTGAA TGAATGAACT CTGATACCCA ATCTGTCTC GAGCC=TCTC TATGCCACTC ATGGCTCCTC TTCTGCTCTT TCCATCTT TGCTGAGAGT TACTGAGCTC TGTACTTCCT CITGGCCCAT CTCACTTCCT GAAACACCCC TGAAGAGGGT TGCTTATCTT GATGGAACTC AAAAAGCCAA AAAGCTGCAG GCAGAGGCGT TGAGGACATC TGTTTGGGGA ACTAAGAGCA GCAGCACTT CAGATTCAGT CCATATAGAG CTGTCCTACA GCATTCTGGA AACTGAGGA TGTGCGGTGC ATAAAGGGGC TGGAAGTGAC CCACCTGTGA TGAGCCCT CTAAGGAGAA GGGTTTCCAA GAGATCACCC CACCAGAAAA GGGTAGGAAT GAGCAAGTTG GGAATlTTAG WO 00/09525 PCTfUS99/1 7712 EPI-109 105 ACTGTCACTG CACATGGACC TCTGGGAAGA CGTCTGGCGA GAGCTAGGCC CACTGGCCCT ACAGACGGAT CTTGCTGGCT CACCTGTCCC TGTGGAGGF1 CCCCTGGGAA GGCAAGATGC CCAACAACAG CACTGCTCTG CGAATFCGGG GGACATCTGT TrGGGGAACT AAGAGCAGCA GCAC=hCAG ATTCAGTCCA TATAGAGCTG TCCTACAGCA TrCTGGAAAC FrGAGGATGT GCGGTGCATA AACGGGCTGG AAGTGACCCA CCTGTGATGA GCCCITCTA AGGAGAAGGG I17CCAAGAG ATCACCCCAC CAGAAAAGGG TAGGAATGAG CAAGTTGGGA A1TrAGACT GTCACTGCAC ATGGACCTCr GGGAAGACGT CTGGCGAGAG CTAGGCCCAC TGGCCCTACA GACGGATCTr GCTGGCTCAC CTGTCCCTGT GGAGGT7CCC CTGGGAAGGC AAGATGCCCA ACAACAGCAC TGCTCTGTCA TrGGCCAATG TrACCTACAT CACCATGGAA ATI=CATrG GACTCTGCGC CATAGTGGGC AACGTGCTGG TCATCTrGCGT GGTCAAGCTG AACCCCAGCC TGCAGACCAC CACC'ICTAT TTCATTGTCT CTCTAGCCCT GGCTrGACAT'T GCTGTrGGGG TGCTGGTCAT GCC1TGGCC ATTG'rTGTCA GCCTGGGCAT CACAATCCAC TrCTACAGCT GCCTIT=AT GACrTGCCTA CTGCTrATCT TrACCCACGC CTCCATCATG TCCTGCTGG CCATCGCTGT GGACCGATAC 7rGCGGGTCA AGCTIACCGT CAGATACAAG AGGGTCACCA CTCACAGAAG AATATGGCTG GCCCTGGGCC T1TrGCTGGCT GGTGTCATTC CTGGTGGGAT TGACCCCCAT GTIT7GGCTGG AACATGAAAC TGACCTCAGA GTACCACAGA AATGTCACCT TCC'TICATG CCAAMhGT17 TCCGTCATGA GGATGGACTA CATGGTATAC 'ITCAGC'rCC TCACCTGGAT 'IMCATCCCC CTGGTTGTCA TGTGCGCCAT CTATCTTGAC ATCFITACA TCATTCGGAA CAAACTCAGT CTGAACTrAT CTAACTCCAA AGAGACAGGT GCAT1TATG GACGGGAGTT CAAGACGGCT AAGTCC17GT FTCTGGTTC7T rcTrG'IM GCTCTGTCAT GGCTGCCTT ATCTCTCATC AACTGCATCA TCrACTIAA TGGTGAGGTA CCACAGC11TG TGCTGTACAT GGGCATCCTG CTGTCCCATG CCAACTCCAT GATcIAACCCT ATCGTCTATG CCTATAAAAT AAAGAAGUC AAGGAAACCT ACCTI=GAT CCTCAAAGCC TGTGTGGTCT GCCATCCCTC TGATrC1TG GACACAAGCA TTGAGAAGAA TTCTGAGTAG TTATCCATCA GAGATGACTC TGTCTCATTG ACC=CAGAT TCCCCATCAA CAAACAC17G AGGGCCTGTA TGCCTGGGCC AAGGGA'II1 TACATCCTG ATTACI'rCCA CTGAGGTGGG AGCATUITCCA GTGCTCCCCA ATFATATCTC CCCCACTCCA CTACTCrCTr CCTCCA=~C ArrrfC=r TGTC=IICT CTCTAMTrCA GTGTITGGA GGCCTGAVIT GGGGACAACG TATlATFJMAT ATrATTGTCT GT1TCCTIC 17CCCAATAG AAGAATAAGT CATGGAGCCT GAAGGGTGCC TAGT7GACTT ACTGACAAAA GGCTCTAGTT GGGCTGAACA TGTGTGTGGT GGTGACTCAT TTCCATGCCA T7GTGGAAT-r GAGCAGAGAA CCTGCTCTCG GAGGATGCCT AGGAGATGTT GGGAACAGAA GAAATAAACT GAGTI1AAGG GGGACTTAAA CTGCTGAATr C GAATrCCCAG ATGGGCAGAG GTGGCTGGGC TGGTGACCCT AAGTGTGTCT CCTGCC1T1A TTCTCTCTAG TGGGTrATrC 1CATGTGG TATCrrGCCT ACAGCATGCT GTGM~GGAC ACAAACCCCr TTCCTTGG T TCTCTGACCC AGCTGAGATG GACTGAT7CC AAAAGAACTC ACCTATGTAC TGGGGTAGGG GAGGGAGGGT 'TITTGCAGT An7TAACTAA GGTCAAAGA GTGCTATATA GTGAGAAAGG CTrVIrflT 7ITITIITI1 TITh=GGCA GAGTGCTGCC TCCTAGAAAT TrCrCrrGGT AACflTCCT17C TCTGAAGCAC AGATAAAGAA AACAATrACA GTAGAAACAT T7ATGAGGGA CACAT7GGAG GCCGATGAAG CTIT~CAAGT TCCAGCAGTG CAGGGATGTG GGCAGAACTG ACATTGGAAA ATACTAGAAT GATGGAAATT CAGTTGGAGA GGACTGCCCI2 FIAATGTC TGGGGAGTCT GCTCAGGGAG AAATGACAAG TCTGGCGGGG ACAAGTATGG GA'1GGTAA GACT7GGATC AACTrGGGAT ACAGGGTGGG GGTCGGGAGT GGAATCAATG AATGATGCCA GAGCAGATCA ACTAACAAGA GGACCCTGAT GAGCCCCAGG CAGAGGCGTC TCCGT17ATGC CCCACTCTGA AGTGTT7GTT AGTAAACACC AGAACGCCAT TGTTGT'TACT GCTGAATIT ATITJGGGCT GTACATA'IM AGATG=TAA GGTAAAAATG ATAAAGCCCT CAAGCCACTG TGTGGG'FIG GGTCCAAGTG 'FrCCrTrCrG CTGCCTCTCT AACACGCCTG GTTAAAATAA TCC=~lGGA TGGTGCTGAG AAGCACCTGA ACCAAGTGGG TCCCCAAATA ACAATGGCGT GCAAGTGTCT GGTTCCCAGA AGTrGGTGAC TAGGTAAGCA GCTCAGGGA GAGGGGGCTG ATrCCCAGAC AGTCGCCTGT TCCTGCGGGG ATGGGGCTGA GGCTTGGGGA ATGTGGGCAG GAGGATATGC CAn7GAflC TGTTGCACAC GTTC=r~CC CT=1TCTG TATGT~TGGT CA17CTrGCTA TrCTGTCGTr CCTCACATAG G F7GGACAT7 GGCCGGCTGC CAGCATAAGT GCCAGTGTGA TITGCTAGG TGTGAGCTGA GAAAGAGAGG TGGAGGCTAA GCAGGTGTGA TGC7rCTCAG AGGTGCTGAG 7flTGCCCT TCTGAGCAGG GAATCMrGC TTATCCCIT GACCAAGGAT CTTGCTGCA AAGGCTGGGT ATCGGCTGTG CTCAGCAAAG CGTCAACTCG TGCAAGAACT TAGCAGGAAT AGTrCTGGCT AAGGT7AGGA GGCTGCCACC AAAGTCTC= =FTGT7CCT CTGCTCC CGTn7GCCTC CTIATCATGA GATCrITG CTAAGCTGGC AGAAAGATTG CATAGTCAGT GCITCCAGCT CTGCTCCCAC CTGATCCTGC ACTGTCCrCr GGTCCCTGAA TGAATGAACT CTGATACCCA ATC'flGTCTC GAGCCTrCrC TATGCCACTC ATGGCTCCTC 'FCTGCTCIT TCCATCITI TGCTGAGAGT TCrGAGCTCT GTACTTCCTC TTGGCCCATC TCACTrCCTG AAACACCCCT GAAGAGGGT7 GCTFATCTTG ATGGAAC1rCA AAAAGCCAAA AAGCTGCAGG CAGAGGCG~f GAGGACATCT GM~GGGGAA CTAAGAGCAG CAGCAC1TC AGATCAGTC CATATAGAGC TGTCCTACAG CATFCTGGAA ACTTGAGGAT GTGCGGTGCA TAAAGGGGCT GGAAGTGACC CACCTGTGAT GAGCC=IIC TAAGGAGAAG GG717CCAAG AGATCACCCC ACCAGAAAAG GGTAGGAATG AGCAAGTTGG GAA=rAGA CTGTCACTGC ACATGGACCT CTGGGAAGAC GTCrGGCGAG AGCTAGGCCC ACTGGCCCTA CAGACGGATC 'rGCTGGCTC ACCTGTCCCT GTGGAGGT7C CCCTGGGAAG GCAAGATGCC CAACAACAGC ACTGCrCTGT CATTGGCCAA TGTrACCTAC ATCACCATGG AAATITCAT TGGACTCTGC GCCATAGTGG GCAACGTGCT GGTCATCTGC GTGGTCAAGC TGAACCCCAG CCTGCAGACC ACCACCrrCT A=~CATTGT CTCTCTAGCC CTGGCTrGACA TTGCTG'ITGG GGTGCTGGTC ATGCCT=GG CCAT-rGTrGT CAGCCTGGGC ATCACAATCC ACCACAG CTGCCTIT ATGACTTGCC TACTGCTrAT CI=ACCCAC GCCTCCATCA TGTCCTTGCT GGCCATCGCT GTGGACCGAT ACTrGCGGGT CAAGC'ITACC GTCAGGTAGC CTGCGGCGTG GGGTGGGCAG CAATrGAGGC AGCTGGGAAA TGAGGCTACA AAGCCAGAGC CTGCTGAATr 'FTrTGGA CTGTACATAT TrAGATGCT17 AAGGTAAAAA TGATAAAGCC CTCAAGCCAC TGTGTGGGTF[ GGGTCCAAGT GT7CC17GCT GCTGCCTCTC TAACACGCCT GGTTAAAATA ATCCCITGG ATGGTGCTGA GAAGCACCTG AACCAAGTGG GTCCCCAAAT AACTATGGCG TGCAAGTGTC TGG'TrCCCAG AAGT7GGTGA CTAGGTAAGC GACTCAGGGA GAGGGGCrGA TTCCCAGACA GTCGCCTGTT1 CCTGCTGGGA TGGGGCTGAG GCTTGGGGAA TGTGGGCAGG AGGATATGCC ATTrGAT7r GTrGCACACG TrCTI=CCC TrTrTrGT ATGTCTGGTC ATrCTGC-TAT TCTGTCGTTC CTCACATAGG TlGGACATTG GCCGGCTGCC AGCATAAGTG CCAGTGTGAT TIT7GCTAGGG TGTGAGCTGA GAAAGAGAGG TGGAGGCTAA GCAGGTGTGA TGCTTCTCAG AGGTGCTGAG TI=rGCCCT TCTGAGCAGG GAAT='~GC FrATCCCTIIr GACCAAGGAT C1TGCTCCA AAGGCTGGGT ATCGGCTGTG CTCAGCAAAG CGTCAACTCG TGCAAGAACr TAGCAGGAAT AGflCTGGCT AAGGTTAGGA GGCTGCCACC AAAGTCTC= rrrrTrCCT CTGCTrCTCC CG'IMGCCTC CTrATCATGA GATCT1TG CTAAGCTGGC AGAAAGAT7G CATAATCAGT GCTFCCAGCT CCGCTCCCAC CTFGATCCTGC ACTGTCCTCr GGTCCCTGAA TGAATGAACT CTGATACCCA ATCTTGTCTC GAGCCTTCTC TATGCCACTC ATGGCTCCTC TTCTGCTrCTr TCCATCT1T TGCTGAGAGT WO 00/09525 PCT/US99/17712 EPI-109 106 TACTGAGCTC TGTACTTCCT CTTGGCCCAT CTCACTTCCT GAAACACCCC TGAAGAGGGT TGCTTATCTT GATGGAACTC AAAAAGCCAA AAAGCTGCAG GCAGAGGCGT TGAGGACATC TGMGGGGA ACTAAGAGCA GCAGCACTTT CAGATTCAGT CCATATAGAG CTGTCCTACA GCATrCTGGA AACTTGAGGA TGTGCGGTGC ATAAAGGGGC TGGAAGTGAC CCACCTGTGA TGAGCCCT CTAAGGAGAA GGGTTTCCAA GAGATCACCC CACCAGAAAA GGGTAGGAAT GAGCAAGTTG GGAATAG ACTGTCACTG CACATGGACC TCTGGGAAGA CGTCTGGCGA GAGCTAGGCC CACTGGCCCT ACAGACGGAT CTTGCTGGCT CACCTGTCCC TGTGGAGGTr CCCCTGGGAA GGCAAGATGC CCAACAACAG CACTGCTCTG CGAATrCGGG GGACATCTGT TTGGGGAACT AAGAGCAGCA GCACTTTCAG ATTCAGTCCA TATAGAGCTG TCCTACAGCA TTCTGGAAAC TTGAGGATGT GCGGTGCATA AACGGGCTGG AAGTGACCCA CCTGTGATGA GCCCTCTA AGGAGAAGGG TTTCCAAGAG ATCACCCCAC CAGAAAAGGG TAGGAATGAG CAAGTrGGGA ATAGACT GTCACTGCAC ATGGACCTCT GGGAAGACGT CTGGCGAGAG CTAGGCCCAC TGGCCCTACA GACGGATCTT GCTGGCTCAC CTGTCCCTGT GGAGGTTCCC CTGGGAAGGC AAGATGCCCA ACAACAGCAC TGCTCTGTCA TTGGCCAATG TTACCTACAT CACCATGGAA ATTTTCATTG GACTCTGCGC CATAGTGGGC AACGTGCTGG TCATCTGCGT GGTCAAGCTG AACCCCAGCC TGCAGACCAC CACCTrCTAT TTCATTGTCT CTCTAGCCCT GGCTGACATT GCTGTTGGGG TGCTGGTCAT GCC'TGGCC ATTGTTGTCA GCCTGGGCAT CACAATCCAC TTCTACAGCT GCCITITIAT GACTTGCCTA CTGCTTATCT TTACCCACGC CTCCATCATG TCCTTGCTGG CCATCGCTGT GGACCGATAC TTGCGGGTCA AGCTTACCGT CAGATACAAG AGGGTCACCA CTCACAGAAG AATATGGCTG GCCCTGGGCC TTTGCTGGCT GGTGTCATTC CTGGTGGGAT TGACCCCCAT GTTTGGCTGG AACATGAAAC TGACCTCAGA GTACCACAGA AATGTCACCT TCCTTTCATG CCAATTTGTT TCCGTCATGA GGATGGACTA CATGGTATAC TTCAGCTTCC TCACCTGGAT TTTCATCCCC CTGGTTGTCA TGTGCGCCAT CTATCTGAC ATCTi-ACA TCATTCGGAA CAAACTCAGT CTGAACTTAT CTAACTCCAA AGAGACAGGT GCATTTATG GACGGGAGTT CAAGACGGCT AAGTCCTTGT TCTGGTTCT 'TrCTrGTTT GCTCTGTCAT GGCTGCCTTT ATCTCTCATC AACTGCATCA TCTACTAA TGGTGAGGTA CCACAGCTT7G TGCTGTACAT GGGCATCCTG CTGTCCCATG CCAACTCCAT GATGAACCCT ATCGTCTATG CCTATAAAAT AAAGAAGTTC AAGGAAACCT ACCTTITGAT CCTCAAAGCC TGTGTGGTCT GCCATCCCTC TGATTCTTTG GACACAAGCA TTGAGAAGAA TTCTGAGTAG TTATCCATCA GAGATGACTC TGTCTCATTG ACCTTCAGAT TCCCCATCAA CAAACACTTG AGGGCCTGTA TGCCTGGGCC AAGGGATTIT TACATCCTTG ATTACTTCCA CTGAGGTGGG AGCATCTCCA GTGCTCCCCA ATTATATCTC CCCCACTCCA CTACTCTCTT CCTCCACTTC A TITCCTT TGTCCTTCT CTCTAATTCA GTGTTTGGA GGCCrGACTT GGGGACAACG TA'TATTGAT ATTATTGTCT G'I irCCTTC TTCCCAATAG AAGAATAAGT CATGGAGCCT GAAGGGTGCC TAGTTGACTT ACTGACAAAA GGCTCTAGTT GGGCTGAACA TGTGTGTGGT GGTGACTCAT TTCCATGCCA TTGTGGAATT GAGCAGAGAA CCTGCrCTCG GAGGATGCCT AGGAGATGTT GGGAACAGAA GAAATAAACT GAGTTTAAGG GGGACTTAAA CTGCTGAATT C -3' (FRAG. NO:1675) (SEQ. ID NO:1688) 5'- CGAATrCGGG GGACATCTGT TTGGGGAACT AAGAGCAGCA GCACTTTCAG ATTCAGTCCA TATAGAGCTG TCCTACAGCA TTCTGGAAAC TTGAGGATGT GCGGTGCATA AACGGGCTGG AAGTGACCCA CCTGTGATGA GCCCTTTCTA AGGAGAAGGG TTTCCAAGAG ATCACCCCAC CAGAAAAGGG TAGGAATGAG CAAGTTGGGA ATITTAGACT GTCACTGCAC ATGGACCTCT GGGAAGACGT CTGGCGAGAG CTAGGCCCAC TGGCCCTACA GACGGATCTT GCTGGCTCAC CTGTCCCTGT GGAGGTTCCC CTGGGAAGGC AAGATGCCCA ACAACAGCAC TGCTCTGTCA TTGGCCAATG TTACCTACAT CACCATGGAA ATTTCATTG GACTCTGCGC CATAGTGGGC AACGTGCTGG TCATCTGCGT GGTCAAGCTG AACCCCAGCC TGCAGACCAC CACCTTCTAT TrCATrGTCT CTCTAGCCCT GGCTGACATT GCTGTTGGGG TGCTGGTCAT GCCTGGCC ATrGTTGTCA GCCTGGGCAT CACAATCCAC TTCTACAGCT GCCT111TAT GACTTGCCTA CTGCTITATCT TTACCCACGC CTCCATCATG TCCTTGCTGG CCATCGCTGT GGACCGATAC TTGCGGGTCA AGCTTACCGT CAGATACAAG AGGGTCACCA CTCACAGAAG AATATGGCTG GCCCTGGGCC TTTGCTGGCT GGTGTCATTC CTGGTGGGAT TGACCCCCAT GTTTGGCTGG AACATGAAAC TGACCTCAGA GTACCACAGA AATGTCACCT TCCTTTCATG CCAATTTGTT TCCGTCATGA GGATGGACTA CATGGTATAC TTCAGCTTCC TCACCTGGAT TTTCATCCCC CTGGTTGTCA TGTGCGCCAT CTATCTTGAC ATCTI iACA TCATTCGGAA CAAACTCAGT CTGAACTTAT CTAACTCCAA AGAGACAGGT GCATTATG GACGGGAGTT CAAGACGGCT AAGTCCTTGT TTCTGGTTCT TTTCTTGTIT GCTCTGTCAT GGCTGCCTTT ATCTCTCATC AACTGCATCA TCTACTTAA TGGTGAGGTA CCACAGCTTG TGCTGTACAT GGGCATCCTG CTGTCCCATG CCAACTCCAT GATGAACCCT ATCGTCTATG CCTATAAAAT AAAGAAGTTC AAGGAAACCT ACCT=TGAT CCTCAAAGCC TGTGTGGTCT GCCATCCCTC TGATTCTTTG GACACAAGCA TTGAGAAGAA TTCTGAGTAG TTATCCATCA GAGATGACTC TGTCTCATTG ACCTTCAGAT TCCCCATCAA CAAACACTTG AGGGCCTGTA TGCCTGGGCC AAGGGATT TACATCCTTG ATTACTTCCA CTGAGGTGGG AGCATCTCCA GTGCTCCCCA ATTATATCTC CCCCACTCCA CTACTCTC CCTCCACTTC ATTTCCTT TGTCCTTTCT CTCTAATTCA GTGITTGGA GGCCTGACTT GGGGACAACG TATTAT7GAT ATTATTGTCT GTITTCCTTC TTCCCAATAG AAGAATAAGT CATGGAGCCT GAAGGGTGCC TAGTTGACTT ACTGACAAAA GGCTCTAGTT GGGCTGAACA TGTGTGTGGT GGTGACTCAT TTCCATGCCA TTGTGGAATT GAGCAGAGAA CCTGCTCTCG GAGGATGCCT AGGAGATGTT GGGAACAGAA GAAATAAACT GAGTTTAAGG GGGACTrAAA CTGCTGAATT C -3' (FRAG. NO:_) (SEQ. ID NO:2439) 5'- CTGCTGAATT TTAT1TTGGA CTGTACATAT TTAGATGCTT AAGGTAAAAA TGATAAAGCC CTCAAGCCAC TGTGTGGGTT GGGTCCAAGT GTTCCTTGCT GCTGCCTCTC TAACACGCCT GGTTAAAATA ATCCCTGG ATGGTGCTGA GAAGCACCTG AACCAAGTGG GTCCCCAAAT AACTATGGCG TGCAAGTGTC TGGTTCCCAG AAGTTGGTGA CTAGGTAAGC GACTCAGGGA GAGGGGCTGA TTCCCAGACA GTCGCCTGTT CCTGCTGGGA TGGGGCTGAG GCTTGGGGAA TGTGGGCAGG AGGATATGCC ATGATTCT GT7GCACACG TTUITITCCC TTCTTTCTGT ATGTCTGGTC ATTCTGCTAT TCTGTCGTTC CTCACATAGG TTGGACATTG GCCGGCTGCC AGCATAAGTG CCAGTGTGAT TGCTAGGG TGTGAGCTGA GAAAGAGAGG TGGAGGCTAA GCAGGTGTGA TGCTTCTCAG AGGTGCTGAG TTF-1GCCCT TCTGAGCAGG GAATCTTGC TrATCCC'TT GACCAAGGAT CTGCTCCA AAGGCTGGGT ATCGGCTGTG CTCAGCAAAG CGTCAACTCG TGCAAGAACT TAGCAGGAAT AGTrCTGGCT AAGGTTAGGA GGCTGCCACC AAAGTCTCTT TTGTrCCT CTGCTTCTCC CGTTTGCCTC CTTATCATGA GATC'I-iirG CTAAGCTGGC AGAAAGATTG CATAATCAGT GCTTCCAGCT CCGCTCCCAC CTGATCCTGC ACTGTCCTCT GGTCCCTGAA TGAATGAACT CTGATACCCA ATCTTGTCTC GAGCCTTCTC TATGCCACTC ATGGCTCCTC TTCTGCTCT TCCATCTTTT TGCTGAGAGT TACTGAGCTC TGTACTTCCT CTTGGCCCAT CTCACTTCCT GAAACACCCC TGAAGAGGGT TGCTTATCTT GATGGAACTC AAAAAGCCAA AAAGCTGCAG GCAGAGGCGT TGAGGACATC TGTTGGGGA ACTAAGAGCA GCAGCACTT WO 00/09525 PCT/US99/17712 EPI-109 107 CAGATTCAGT CCATATAGAG CTGTCCTACA GCATrCTGGA AACTTGAGGA TGTGCGGTGC ATAAAGGGGC TGGAAGTGAC CCACCTGTGA TGAGCCCTT CTAAGGAGAA GGGITTCCAA GAGATCACCC CACCAGAAAA GGGTAGGAAT GAGCAAGTTG GGAATTTTAG ACTGTCACTG CACATGGACC TCTGGGAAGA CGTCTGGCGA GAGCTAGGCC CACTGGCCCT ACAGACGGAT CTTGCTGGCT CACCTGTCCC TGTGGAGGTT CCCCTGGGAA GGCAAGATGC CCAACAACAG CACTGCTCTG -3' FRAGG. NO:-) (SEQ. ID NO:2438) 5'- GAATrCCCAG ATGGGCAGAG GTGGCTGGGC TGGTGACCCT AAGTGTGTCT CCTGCCTA TTCTCTCTAG TGGGT'TATTC ITCATGTGG TATCTTGCCT ACAGCATGCT GTGTTTGGAC ACAAACCCCT TTCCTTGGTT TCTCTGACCC AGCTGAGATG GACTGATTCC AAAAGAACTC ACCTATGTAC TGGGGTAGGG GAGGGAGGGT T1GCAGT ATTTAACTAA GGTTCAAAGA GTGCTATATA GTGAGAAAGG CrrCITi1r T1TI1111 TTrGGCA GAGTGCTGCC TCCTAGAAAT TTCTCTTGGT AACTTCCTTC TCTGAAGCAC AGATAAAGAA AACAATTACA GTAGAAACAT TTATGAGGGA CACATTGGAG GCCGATGAAG CTTTTCAAGT TCCAGCAGTG CAGGGATGTG GGCAGAACTG ACATTGGAAA ATACTAGAAT GATGGAAATT CAGTTGGAGA GGACTGCCCT TT-11AATGTC TGGGGAGTCT GCTCAGGGAG AAATGACAAG TCTGGCGGGG ACAAGTATGG GATrTGGTAA GACTTGGATC AACTTGGGAT ACAGGGTGGG GGTCGGGAGT GGAATCAATG AATGATGCCA GAGCAGATCA ACTAACAAGA GGACCCTGAT GAGCCCCAGG CAGAGGCGTC TCCCTTATGC CCCACTCTGA AGTGTGTT AGTAAACACC AGAACGCCAT TGTTGTTACT GCTGAATT ATTTTGGGCT GTACATATTT AGATGCTTAA GGTAAAAATG ATAAAGCCCT CAAGCCACTG TGTGGGTTTG GGTCCAAGTG TTCCTTCTTG CTGCCTCTCT AACACGCCTG GTTAAAATAA TCCC=TTGGA TGGTGCTGAG AAGCACCTGA ACCAAGTGGG TCCCCAAATA ACAATGGCGT GCAAGTGTCT GGTTCCCAGA AGTTGGTGAC TAGGTAAGCA GCTTCAGGGA GAGGGGGCTG ATTCCCAGAC AGTCGCCTGT TCCTGCGGGG ATGGGGCTGA GGCTTGGGGA ATGTGGGCAG GAGGATATGC CATGATTC TGTTGCACAC GTrC1111CC CTTCTTCTG TATGTCTGGT CATTCTGCTA TTCTGTCGTT CCTCACATAG GTTGGACATT GGCCGGCTGC CAGCATAAGT GCCAGTGTGA TGCTAGG TGTGAGCTGA GAAAGAGAGG TGGAGGCTAA GCAGGTGTGA TGCTrTCAG AGGTGCTGAG 1ITTGCCCT TCTGAGCAGG GAATCTGC TTATCCCTT GACCAAGGAT CTTTGCTGCA AAGGCTGGGT ATCGGCTGTG CTCAGCAAAG CGTCAACTCG TGCAAGAACT TAGCAGGAAT AGTTCTGGCT AAGGTTAGGA GGCTGCCACC AAAGTCTCTT TTTGTTCCT CTGCTTCTCC CGTTTGCCTC CTTATCATGA GATCITIT=G CTAAGCTGGC AGAAAGAT7G CATAGTCAGT GCTTCCAGCT CTGCTCCCAC CTGATCCTGC ACTGTCCTCT GGTCCCTGAA TGAATGAACT CTGATACCCA ATCTTGTCTC GAGCCTTCTC TATGCCACTC ATGGCTCCTC TTCTGCTCTT TCCATCTTIT TGCTGAGAGT TCTGAGCTCT GTACTTCCTC TTGGCCCATC TCACTTCCTG AAACACCCCT GAAGAGGGTT GCTTATCTTG ATGGAACTCA AAAAGCCAAA AAGCTGCAGG CAGAGGCGTT GAGGACATCT GTTTGGGGAA CTAAGAGCAG CAGCACTC AGATTCAGTC CATATAGAGC TGTCCTACAG CATTCTGGAA ACTTGAGGAT GTGCGGTGCA TAAAGGGGCT GGAAGTGACC CACCTGTGAT GAGCCCTITC TAAGGAGAAG GGTT7CCAAG AGATCACCCC ACCAGAAAAG GGTAGGAATG AGCAAGTTGG GAATAGA CTGTCACTGC ACATGGACCT CTGGGAAGAC GTCTGGCGAG AGCTAGGCCC ACTGGCCCTA CAGACGGATC TTGCTGGCTC ACCTGTCCCT GTGGAGGTTC CCCTGGGAAG GCAAGATGCC CAACAACAGC ACTGCTCTGT CATTGGCCAA TGTTACCTAC ATCACCATGG AAA1111CAT TGGACTCTGC GCCATAGTGG GCAACGTGCT GGTCATCTGC GTGGTCAAGC TGAACCCCAG CCTGCAGACC ACCACCTTCT AThTCATTGT CTCTCTAGCC CTGGCTGACA TTGCTGTTGG GGTGCTGGTC ATGCCTTGG CCATTGTTGT CAGCCTGGGC ATCACAATCC ACTTCTACAG CTGCCITIT ATGACTGCC TACTGCTTAT C'TACCCAC GCCTCCATCA TGTCCTTGCT GGCCATCGCT GTGGACCGAT ACTTGCGGGT CAAGCTTACC GTCAGGTAGC CTGCGGCGTG GGGTGGGCAG CAATTGAGGC AGCTGGGAAA TGAGGCTACA AAGCCAGAGC -3' (FRAG. NO:_) (SEQ. ID NO:2437) 5'-CGAATrCGGG GGACATCTGT TTGGGGAACT AAGAGCAGCA GCACTTCAG ATTCAGTCCA TATAGAGCTG TCCTACAGCA TrCTGGAAAC TTGAGGATGT GCGGTGCATA AACGGGCTGG AAGTGACCCA CCTGTGATGA GCCCTTTCTA AGGAGAAGGG TTTCCAAGAG ATCACCCCAC CAGAAAAGGG TAGGAATGAG CAAGTTGGGA ATTTAGACT GTCACTGCAC ATGGACCTCT GGGAAGACGT CTGGCGAGAG CTAGGCCCAC TGGCCCTACA GACGGATCTT GCTGGCTCAC CTGTCCCTGT GGAGGTTCCC CTGGGAAGGC AAGATGCCCA ACAACAGCAC TGCTCTGTCA TTGGCCAATG TTACCTACAT CACCATGGAA ATTTCATTG GACTCTGCGC CATAGTGGGC AACGTGCTGG TCATCTGCGT GGTCAAGCTG AACCCCAGCC TGCAGACCAC CACCTTCTAT TTCATrGTCT CTCTAGCCCT GGCTGACATT GCTGTTGGGG TGCTGGTCAT GCCTGGCC ATTGTTGTCA GCCTGGGCAT CACAATCCAC TTCTACAGCT GCC'IT-IrAT GACTTGCCTA CTGCTTATCT T'TACCCACGC CTCCATCATG TCCTTGCTGG CCATCGCTGT GGACCGATAC TTGCGGGTCA AGCTTACCGT CAGATACAAG AGGGTCACCA CTCACAGAAG AATATGGCTG GCCCTGGGCC TTTGCTGGCT GGTGTCATTC CTGGTGGGAT TGACCCCCAT GTTTGGCTGG AACATGAAAC TGACCTCAGA GTACCACAGA AATGTCACCT TCCT'CATG CCAA1TTGTT TCCGTCATGA GGATGGACTA CATGGTATAC TrCAGCTTCC TCACCTGGAT TTCATCCCC CTGGTTGTCA TGTGCGCCAT CTATCTTGAC ATC1111ACA TCATTCGGAA CAAACTCAGT CTGAACTrAT CTAACTCCAA AGAGACAGGT GCATTTATG GACGGGAGTT CAAGACGGCT AAGTCCTrGT TTCTGGTCT TCTTGT GCTCTGTCAT GGCTGCCTTT ATCTCTCATC AACTGCATCA TCTACTTAA TGGTGAGGTA CCACAGCTTG TGCTGTACAT GGGCATCCTG CTGTCCCATG CCAACTCCAT GATGAACCCT ATCGTCTATG CCTATAAAAT AAAGAAGTrC AAGGAAACCT ACCTTTGAT CCTCAAAGCC TGTGTGGTCT GCCATCCCTC TGATTCTrG GACACAAGCA TTGAGAAGAA TTCTGAGTAG TTATCCATCA GAGATGACTC TGTCTCATTG ACCTTCAGAT TCCCCATCAA CAAACACTTG AGGGCCTGTA TGCCTGGGCC AAGGGATrT TACATCCTTG ATTACTTCCA CTGAGGTGGG AGCATCTCCA GTGCTCCCCA ATTATATCTC CCCCACTCCA CTACTCTCTT CCTCCACTTC ATTCCTT TGTCCTTCT CTCTAATTCA GTGTTTGGA GGCCTGACTT GGGGACAACG TATTATTGAT ATTATTGTCT GTTCCTTC TTCCCAATAG AAGAATAAGT CATGGAGCCT GAAGGGTGCC TAGTTGACTT ACTGACAAAA GGCTCTAGTT GGGCTGAACA TGTGTGTGGT GGTGACTCAT TTCCATGCCA TTGTGGAATT GAGCAGAGAA CCTGCTCTCG GAGGATGCCT AGGAGATGT[ GGGAACAGAA GAAATAAACT GAGTTAAGG GGGACTTAAA CTGCTGAATT C -3' (FRAG. NO:_) (SEQ. ID NO:2427) 5'-CTGCTGAATr TTATTGGA CTGTACATAT TrAGATGCTT AAGGTAAAAA TGATAAAGCC CTCAAGCCAC TGTGTGGGTT GGGTCCAAGT GTTCCTTGCT GCTGCCTCTC TAACACGCCT GGTTAAAATA ATCCCTTGG ATGGTGCTGA GAAGCACCTG AACCAAGTGG GTCCCCAAAT AACTATGGCG TGCAAGTGTC TGGTTCCCAG AAGTTGGTGA CTAGGTAAGC GACTCAGGGA GAGGGGCTGA TTCCCAGACA GTCGCCTGTF CCTGCTGGGA TGGGGCTGAG GCTTGGGGAA TGTGGGCAGG AGGATATGCC ATGATTCT GTTGCACACG TTCTTTTCCC TTCTTCTGT ATGTCTGGTC ATTCTGCTAT TCTGTCGTTC CTCACATAGG TTGGACATTG GCCGGCTGCC AGCATAAGTG CCAGTGTGAT TrGCTAGGG TGTGAGCTGA GAAAGAGAGG TGGAGGCTAA WO 00/09525 PCT/US99/17712 EPI-109 108 GCAGGTGTGA TGCTTCTCAG AGGTGCTGAG 1ITTTGCCCT TCTGAGCAGG GAATCTTGC TTATCCCT GACCAAGGAT CTTTGCTCCA AAGGCTGGGT ATCGGCTGTG CTCAGCAAAG CGTCAACTCG TGCAAGAACT TAGCAGGAAT AGTTCTGGCT AAGGTrAGGA GGCTGCCACC AAAGTCTCTT TTTTGTTCCT CTGCTTCTCC CGTTTGCCTC CTTATCATGA GATCTITITG CTAAGCTGGC AGAAAGATTG CATAATCAGT GCTTCCAGCT CCGCTCCCAC CTGATCCTGC ACTGTCCTCT GGTCCCTGAA TGAATGAACT CTGATACCCA ATCTTGTCTC GAGCCTTCTC TATGCCACTC ATGGCTCCTC TTCTGCTCTT TCCATCTIT TGCTGAGAGT TACTGAGCTC TGTACTTCCT CTTGGCCCAT CTCACTTCCT GAAACACCCC TGAAGAGGGT TGCTTATCTT GATGGAACTC AAAAAGCCAA AAAGCTGCAG GCAGAGGCGT TGAGGACATC TGTTTGGGGA ACTAAGAGCA GCAGCACTTT CAGATTCAGT CCATATAGAG CTGTCCTACA GCA'TTCTGGA AACTTGAGGA TGTGCGGTGC ATAAAGGGGC TGGAAGTGAC CCACCTGTGA TGAGCCCTTT CTAAGGAGAA GGGTITCCAA GAGATCACCC CACCAGAAAA GGGTAGGAAT GAGCAAGTTG GGAATTTTAG ACTGTCACTG CACATGGACC TCTGGGAAGA CGTCTGGCGA GAGCTAGGCC CACTGGCCCT ACAGACGGAT CTTGCTGGCT CACCTGTCCC TGTGGAGGTT CCCCTGGGAA GGCAAGATGC CCAACAACAG CACTGCTCTG-3' (FRAG. NO:-) (SEQ. ID NO:2426) 5'-GAATTCCCAG ATGGGCAGAG GTGGCTGGGC TGGTGACCCT AAGTGTGTCT CCTGCCTTTA TrCTCTCTAG TGGGTTATTC TTTCATGTGG TATCTTGCCT ACAGCATGCT GTGITGGAC ACAAACCCCT TTCCTTGGTT TCTCTGACCC AGCTGAGATG GACTGATTCC AAAAGAACTC ACCTATGTAC TGGGGTAGGG GAGGGAGGGT 1T1ITTGCAGT ATTTAACTAA GGTTCAAAGA GTGCTATATA GTGAGAAAGG CTTCITIT iTITITITIT 1TITGGCA GAGTGCTGCC TCCTAGAAAT TTCTCTTGGT AACTTCCTTC TCTGAAGCAC AGATAAAGAA AACAATTACA GTAGAAACAT T TATGAGGGA CACATTGGAG GCCGATGAAG CTTTTCAAGT TCCAGCAGTG CAGGGATGTG GGCAGAACTG ACATTGGAAA ATACTAGAAT GATGGAAATT CAGTTGGAGA GGACTGCCCT TT1AATGTC TGGGGAGTCT GCTCAGGGAG AAATGACAAG TCTGGCGGGG ACAAGTATGG GATTTGGTAA GACTTGGATC AACTTGGGAT ACAGGGTGGG GGTCGGGAGT GGAATCAATG AATGATGCCA GAGCAGATCA ACTAACAAGA GGACCCTGAT GAGCCCCAGG CAGAGGCGTC TCCCTTATGC CCCACTCTGA AGTGTTTGTT AGTAAACACC AGAACGCCAT TGTTGTTACT GCTGAATlr ATTTTGGGCT GTACATATTT AGATGCTTAA GGTAAAAATG ATAAAGCCCT CAAGCCACTG TGTGGGTTG GGTCCAAGTG TTCCTTCTTG CTGCCTCTCT AACACGCCTG GTTAAAATAA TCCCTTTGGA TGGTGCTGAG AAGCACCTGA ACCAAGTGGG TCCCCAAATA ACAATGGCGT GCAAGTGTCT GGTTCCCAGA AGTTGGTGAC TAGGTAAGCA GCTTCAGGGA GAGGGGGCTG ATTCCCAGAC AGTCGCCTGT TCCTGCGGGG ATGGGGCTGA GGCTTGGGGA ATGTGGGCAG GAGGATATGC CATTTGATTC TGTTGCACAC GTTCTITTCC CTTCTTTCTG TATGTCTGGT CATTCTGCTA TITCTGTCGTT CCTCACATAG GTTGGACATT GGCCGGCTGC CAGCATAAGT GCCAGTGTGA TTITGCTAGG TGTGAGCTGA GAAAGAGAGG TGGAGGCTAA GCAGGTGTGA TGCTTCTCAG AGGTGCTGAG ITlT lGCCCT TCTGAGCAGG GAATCTTTGC TTATCCCTTT GACCAAGGAT CTTTGCTGCA AAGGCTGGGT ATCGGCTGTG CTCAGCAAAG CGTCAACTCG TGCAAGAACT TAGCAGGAAT AGTTCTGGCT AAGGTTAGGA GGCTGCCACC AAAGTCTCTT TTITGTTCCT CTGCTTCTCC CGTTTGCCTC CTTATCATGA GATCITITG CTAAGCTGGC AGAAAGATTG CATAGTCAGT GCTTCCAGCT CTGCTCCCAC CTGATCCTGC ACTGTCCTCT GGTCCCTGAA TGAATGAACT CTGATACCCA ATCTTGTCTC GAGCCTTCTC TATGCCACTC ATGGCTCCTC TTCTGCTCIT TCCATCTITT TGCTGAGAGT TCTGAGCTCT GTACTTCCTC TTGGCCCATC TCACTTCCTG AAACACCCCT GAAGAGGGTT GCTTATCTTG ATGGAACTCA AAAAGCCAAA AAGCTGCAGG CAGAGGCGTT GAGGACATCT GTTTGGGGAA CTAAGAGCAG CAGCACTTTC AGATTCAGTC CATATAGAGC TGTCCTACAG CATTCTGGAA ACTTGAGGAT GTGCGGTGCA TAAAGGGGCT GGAAGTGACC CACCTGTGAT GAGCCCTTTC TAAGGAGAAG GGTTTCCAAG AGATCACCCC ACCAGAAAAG GGTAGGAATG AGCAAGTTGG GAATTTTAGA CTGTCACTGC ACATGGACCT CTGGGAAGAC GTCTGGCGAG AGCTAGGCCC ACTGGCCCTA CAGACGGATC TTGCTGGCTC ACCTGTCCCT GTGGAGGTTC CCCTGGGAAG GCAAGATGCC CAACAACAGC ACTGCTCTGT CATTGGCCAA TGTTACCTAC ATCACCATGG AAATTITCAT TGGACTCTGC GCCATAGTGG GCAACGTGCT GGTCATCTGC GTGGTCAAGC TGAACCCCAG CCTGCAGACC ACCACCTTCT ATTTCATTGT CTCTCTAGCC CTGGCTGACA TTGCTGTTGG GGTGCTGGTC ATGCCTTTGG CCATTGTTGT CAGCCTGGGC ATCACAATCC ACTTCTACAG CTGCC'T11 ATGACTTGCC TACTGCTTAT CTTTACCCAC GCCTCCATCA TGTCCTTGCT GGCCATCGCT GTGGACCGAT ACTTGCGGGT CAAGCTTACC GTCAGGTAGC CTGCGGCGTG GGGTGGGCAG CAATTGAGGC AGCTGGGAAA TGAGGCTACA AAGCCAGAGC-3' (FRAG. NO:_) (SEQ. ID NO:2425) 5'-GBG CB TGC-3' (FRAG. NO:1676) (SEQ. ID NO:1689) 5'-TTG TTG GGC-3' (FRAG. NO:1677) (SEQ. ID NO:1690) 5'-TGC CTT CCC BGG G-3' (FRAG. NO:1678) (SEQ. ID NO:1691) 5'-GTT GTT GGG CAT CTT GCC-3' (FRAG. NO:1679) (SEQ ID NO:3) 5'-GTG GGC CTA GCT CTC GCC-3' (GRAG. NO:1680) (SEQ ID NO:5) 5'-ACA GAG CA TGC TGT TGT TGG GCA TCT TGC CTT CCC AGG G-3' (FRAG 982) (SEQ. ID NO: 992) 5'-BCB GBG CB TGC TGT TGT TGG GCB TCT TGC CTT CCC BGG G-3' (FRAG 983) (SEQ. ID NO: 993) 5'-CCC T TCT GGT GGG GTG-3' (FRAG 984) (SEQ. ID NO: 994) 5'-GTG CTG TTG TTG GGC-3' (FRAG 985) (SEQ. ID NO: 995) 5'-T CIT CTG TTC CC-3 (FRAG 986) (SEQ. ID NO: 996) 5'-CCC TT TCT GGT GGG GTG-3' (FRAG 987) (SEQ. ID NO: 997) 5'-GTG CTG TTG TTG GGC-3' (FRAG 988) (SEQ. ID NO: 998) 5'-TTT CT CTG TTC CC-3' (FRAG 989) (SEQ. ID NO: 999) Human IRE Receptor 0 Nucleic Acid and Antisense Oligonucleotide Fragments 5'-TTT CCC CTG GGT CTT CC CTC CTG CTC TTT TTT C ATT TGC TCT CCT ATr ACT TTC TGT GTC CAT TTT TTC ATT AAC CGA GCT GT BTT TGC TCT CCT BTT BCT TTC TGT GTC CBT liT TTC BTT BBC CGB GCT GT-3' (FRAG. NO:1681) (SEQ. ID NO:1692) 5'-CCC CTG GG-3' (FRAG. NO:1682) (SEQ. ID NO:1693) 5'-GCTCTCCTBTT-3' (FRAG. NO:1683) (SEQ. ID NO:1694) 5'-CBTTBBCCGBGCTG-3' (FRAG. NO:1684) (SEQ. ID NO:1695) 5'-TTT CCC CTG GGT CTT CC-3' (FRAG 990) (SEQ. ID NO: 1000) 5'-CTC CTG CTC liT lT C-3' (FRAG 991) (SEQ. ID NO: 1001) WO 00/09525 PCTIUS99/17712 EPI-109 109 ATGCTCTCCTATTACITCTGTGTCCATTTCATTAACCGAGCTGT (FRAG 992) (SEQ. ID NO: 1002) BTTTGCTCTCCTBTTBCTTCTGTGTCCBTr CBTTBBCCGBGCTGT (FRAG 993) (SEQ. ID NO: 1003) Human Fc-c Receptor CD23 Antigen (IgE Receptor) Nucleic Acid and Antisense Oligonucleotide Fragments 5'-GCC TGT GTC TGT CCT CCT GCT TCG TTC CTC TCG TT1C CTG CTT GGT GCC CTT GCC G GTC CTG CTC CTC CGG GCT GTG G GTC GTG GCC CTG GCT CCG GCT GGT GGG CTC CCC TGG CCT TCG CTG GCT GGC GGC GTG C GGG TCT TGC TCT GGG CCT GGC TGT GGC CGT GGT TGG GGG TCT TC GCT GCC TCC GTT TGG GTG GC TCT CTG AAT ATT GAC CTT CCT CCA TGG CGG TCC TGC TTG GAT TCT CCC GA TCT CTG BBT BTT GBC CTT CCT CCB TGG CGG TCC TGC TTG GBT TCT CCC GB-3' (FRAG 1685) (SEQ. ID NO:1696) 5'-GT CCT CCT-3' (FRAG 1686) (SEQ. ID NO: 1697) 5'-TGT GTC TGT CCT CC-3' (FRAG 1687) (SEQ. ID NO: 1698) 5'-GTG GCC CTG GC-3' (FRAG 1688) (SEQ. ID NO: 1699) 5'-CGT GGT TGG GG-3' (FRAG 1689) (SEQ. ID NO: 1700) 5'-TCT CTG BBT BTT GBC C-3' (FRAG1690) (SEQ. ID NO:1701) 5'-GCC TGT GTC TGT CCT CCT-3' (FRAG 994) (SEQ. ID NO: 1004) 5'-GCT TCG TTC CTC TCG TTC-3' (FRAG 995) (SEQ. ID NO:1005) 5'-CTG CTT GGT GCC CTT GCC G-3' (FRAG 996) (SEQ. ID NO: 1006) 5'-GTC CTG CTC CTC CGG GCT GTG G-3' (FRAG 997) (SEQ. ID NO: 1007) 5'-GTC GTG GCC CrG GCT CCG GCT GGT GGG CTC CCC TGG-3' (FRAG 998) (SEQ. ID NO: 1008) 5'-CCT TCG CTG GCT GGC GGC GTG C-3' (FRAG 999) (SEQ. ID NO: 1009) 5'-GGG TCT TGC TCT GGG CCT GGC TGT-3' (FRAG 1000) (SEQ. ID NO: 1010) 5'-GGC CGT GGT TGG GGG TCT TC-3' (FRAG 1001) (SEQ. ID NO: 1011) 5'-GCT GCC TCC GTT TGG GTG GC (FRAG 1002) (SEQ. ID NO: 1012) 5'-TCT CTG AAT ATT GAC CTT CCT CCA TGG CGG TCC TGC TTG GAT TCT CCC GA (FRAG 1003) (SEQ. ID NO: 1013) 5'-TCT CTG BBT BTT GBC CTT CCT CCB TGG CGG TCC TGC TTG GBT TCT CCC GB (FRAG 1004) (SEQ. ID NO: 1014) Human IgE Receptor a Subunit Nucleic Acid and Antisense Oligonucleotide Fragments 5'- GCC TTT CCT GGT TC CIT MGTT GTT ' GGG GTT TGG CTT ACA GTA GAG TAG GGG ATT CCA TGG CAG GAG CCA TCT TCT TCA TGG ACT CC TrC AAG GAG ACC TTA GGT TTC TGA GGG ACT GCT AAC ACG CCA TCT GGA GC BCB GTB GBG TBG GGG BTT CCB TGG CBG GBG CCB TCT TCT TCB TGG BCT CC TTC BBG GBG BCC TTB GGT TTC TGB GGG BCT GCT BBC BCG CCB TCT GGB GC GTT GTT TTT GGG GTT TGG CTT GCC TTT CCT GGT TCT CTT BCB GTB GBG TBG GGG BTT CCB TGG CBG GBG CCB TCT TCT TCB TGG BCT CC TTC BBG GBG BCC TTB GGT TTC TGB GGG BCT GCT BBC BCG CCB TCT GGB GC-3' (FRAG. NO: 1691) (SEQ. ID NO:1702) 5'- TGG BCT CC -3' (FRAG. NO: 1692) (SEQ. ID NO:1703) 5'-CCB TCT GGB-3' (FRAG. NO: 1693) (SEQ. ID NO:1704) 5'-CT GCT BBC BCG-3' (FRAG. NO: 1694) (SEQ. ID NO:1705) 5'-GTT TTT GGG GTT TG-3' (FRAG. NO: 1695) (SEQ. ID NO:1706) 5'-GCC TT CCT GGT TCT CTT GTT GTT TIT 666 GTT TGG CTT-3' (FRAG. NO:1005) (SEQ. ID NO:1015) 5'-ACAGTAGAGTAGGGGATCCATGGCAGGAGCCATCTTCTTCATGGACTCC-3' (FRAG. NO:1006) (SEQ. ID NO:1016) 5'-TTC AAG GAG ACC TTA GGT TTC TGA GGG ACT GCT AAC ACG CCA TCT GGA GC-3' (FRAG. NO:1007) (SEQ. ID NO:1017) 5'-BCB GTB GBG TBG GGG BTT CCB TGG CBG GBG CCB TCT TCT TCB TGG BCT CC TTC BBG GBG BCC TTB GGT TTC TGB GGG-3' (FRAG. NO:1008) (SEQ. ID NO:1018) 5'-BCT GCT BBC BCG CCB TCT GGB GC-3' (FRAG. NO:1009) (SEQ. ID NO:1019) 5'-GTT GTT TTT G6 GT TGG CTT-3' (FRAG. NO:1010) (SEQ. ID NO:1020) 5'-GCC TTT CCT GGT TCT CTr-3' (FRAG. NO:1011) (SEQ. ID NO:1021) 5 '-BCBGTBGBGTBGGGGBTTCCBTGGCBGGBGCCBTCTTCITCBTGGBCTCC-3' (FRAG. NO:1012) (SEQ. ID NO:1022) 5'-TTC BBG GBG BCC TFB GGT TTC TGB GGG BCT GCT BBC BCG CCB TCT GGB GC-3' (FRAG. NO:1013) (SEQ. ID NO> 1023) Human IgE Receptor (Fc Epsilon R) Nucleic Acid and Antisense Oligonucleotide Fragments 5'-GCC TGT GTC TGT CCT CCT GCT TCG TTC CTC TCG TTC CTG CTT GGT GCC CTT GCC G GTC CTG CTC CTC CGG GCT GTG G GTC CTC GCC CTG GCT CCG GCT GGT GGG CTC CCC TGG CCT TCG CTG GCT GGC GGC GTG C CCC BGB BCG BGB CCC GGB CCG BCB GGC CGT GGT TGG GGG TCT TC GCT GCC TCC GTT TGG GTG GC GAT CTC TGA ATA TTGA CCT TCC ATG GCG GTC CTG CTT GGA GBT CTC TGB BTB TTGB CCT TCC BTG GCG GTC CTG CTT GGB-3' (FRAG: 1696) (SEQ. ID NO:1707) 5'-TCG TTC CTC TCG-3' (FRAG: 1697) (SEQ. ID NO:1708) 5'-BGB BCG BGB C-3' (FRAG: 1698) (SEQ. ID NO:1709) 5'-TGB BTB TTGB-3' (FRAG: 1699) (SEQ. ID NO:1710) 5'-GCC TGT GTC TGT CCT CCT-3' (FRAG. NO:1014) (SEQ. ID NO:1024) 5'-GCT TCG TTC CTC TCG TTC-3' (FRAG. NO:1015)(SEQ. ID NO:1025) 5'-CTG CTT GGT GCC CTT GCC G-3' (FRAG. NO:1016)(SEQ. ID NO:1026) 5'-GTC CTG CTC CTC CGG GCT GTG G-3' (FRAG. NO:1017)(SEQ. ID NO:1027) 5'-GTC CTC GCC CTG GCT CCG GCT GGT GGG CTC CCC TGG-3' (FRAG. NO:1018) (SEQ. ID NO:1028) 5'-CCT TCG CTG GCT GGC GGC GTG C-3' (FRAG. NO:1019) (SEQ. ID NO:1029) 5'-CCC BGB BCG BGB CCC GGB CCG BCB-3' (FRAG. NO:1020) (SEQ. ID NO:1030) 5'-GGC CGT GGT TGG GGG TCT TC-3' (FRAG. NO:1021) (SEQ. ID NO:1031) 5'-GCT GCC TCC GTT TGG GTG GC-3' (FRAG. NO:1022) (SEQ. ID NO:1032) 5'-GBT CTC TGB BTB TTGB CCT TCC BTG GCG GTC CTG CTT GGB-3' (FRAG. NO:1023) (SEQ. ID NO:1033) WO 00/09525 PCT/US99/1 7712 EPI-109 110 Human High Affinity IgE Receptor Oligonucleotide Fragments 5'-AACAAGAAAA GCGTrGGTAG CTCTGGTGAA TCCCAAAAGA ATGTGGCAGT TGCTAGCCAT GCTCCTGAAT ATGTATAAAC AGTACATCAT ATGACTAAGA G'1GACrrA GGGGTTAGAT Tf7ATGTGT7 TGAACCCCAA ATI1AGT7AT7 TAATAGTFFGG CACCCCAAAA CAAGTTACTr AACCTCACTA AGGTrCAGTT TTCCTGTITA TAAAATGTAG ATAGTGATAG TATGTACT= ATAGGATrAT TGTGAAAAAT AAATGAAATA TCAGATTTAT rAGGATAAC ACCTGGCATA TGn1TGGTAT TCAGAATTAG TTGCTGCTGT 71TATTCTGC TCTCCCTTrGC ATCCCAC'TI TCTAAGTrGT AAACTAAATA GTrGTACACA GA'I7GACAGA TTAAGAAAGG CTTGTGATTG TGCTAGACCT ATGCCTATGC CTCTGTCTCA CCAGAT7CCA GGTG3TATATG TGGAGGTGGG ATAGGGAGTG GAGTAAGTGG GTAAATATFA AAT7GCCCAG 7rGGGCACCA TCCTGAATAT TATCTCTAAA GAAAGAAGCA AAACCAGGCA CAGCTGATGG GTTAACCAGA TATGATACAG AAAACAMIIC C=CTGC'= TTGGTI=AA GCCTATA'ITT GAAGCCTrAG ATCTCTCCAG CACAGTAAGC ACCAGGAGTC CATGAAGAAG ATG GAT=TCATG TGGAATGACT GG'I=CATT-C AATAGACTTA AT7CAGCAGT CTGTGGGGAA GAGCAAGGTA TGATAGAATG G'TrCCTCAAG TGCTICAGAT GTGAAGTGGG M~AAATATA CTGTCCCTGT C=c=CAGA GT=~GGTAA AGATAAAATA GGACACTCAT TrAAAAGCAA TC'=GCAAA TGACAAGCCA CTATAGACAT TAATAGAG~r TTCA T7CCA GTAT7ATCAT TAATATCAGA TCCTGGAAGA AGGTTGAGCC TTGACCTAGA GCAAAAAAAC AGAAGAAT7A GTAAAGGAAT CCTGGAGAAA GCCCCTGCTG TGTAM~AAA GGAGAAAGGG AGATCATGYFT GGGAAATTAT AATAT7AAAA GTAAACAAAA GCTAGGAAGT AAAATAAAAT AAATrATATG GCCTAGATCC CCATAAGTAA TGGnITAACT TCTGCCTTCC TGTGTrCTGA GCCAGAT7AG GGCACAGTAG AGAAAGAGGA GTCTCTGAAA ATGYITCCAA TrTCGCTGGT CAGACAGCGG ATCATCAGTG AATCAGATGA AAAMTGTGG AMIIATGCAC TAACTGATCA GCAGGAAATT AAACAAGAAA AGCG~rGGTA GCTCTGGTGA ATCCCAAAAG AAT7GGCAG F1GCTAGCCA TGCTCCTGAA TATGTATAAA CAGTACATCA TATGACTAAG AG'IMGACTr AGGGGTFAGA TIIATGTGT TTGAACCCCA AAT7AGT17AT TTAATAGTTG GCACCCCAAA ACAAGTrACT TAACCTCACT AAGAT7CAGT TITCcTGTT ATAAAATGTA GATAGTGATA GTATGTAC'F TATAGGATI7A 'FrGTGAAAAA TAAATGAAAT ATCAGATTTA '1TAGGATAA CACCTGGCAT ATG'IMGcTA 'I1CAGTAAT7 AG~rGCTGCT GT7ATTCT GCTCTCCCTT GCATCCCACT 'I7rCTAAGIT7 GTAAACTAAA TAGTITGTACA CAGATrGACA GATlAAGAAA GGCTTGTGAT TGTGCTAGAC CTATGCCTCT CTCTCACCAG ATTCCAGGTG TATATGTGGA GGTGGGATAG GGAGTGGAGT AAGTGGGTAA ATA'FrAAA'IT GCCCAGTTGG GCACCATCCT GAATATFATC TCTAAAGAAA GAAGCAAAAC CAGGCACAGC TGATGGGT[A ACCAGATATG ATACAGAAAA CKTr1CC TGC3T1TGG TITAAGCCT ATA'I7rGAAG CCITAGATCT CTCCAGCACA GTAAGCACCA GGAGTCCATG AAGAAGATGG CTCCTGCCAT GGAATCCCCT ACTCTACTGT GTGTAGCCTIT ACTGTr=TC GGTAAGTAGA GATTCAATTA CCCCTCCCAG GGAGGCCCAA ATGAA717GG GGAGCAGCTG GGGTAGGAAC ='~ACTGTG GGTGGTGACT TMTCrAGGA CATGTGCAAA CTAT7GGGCA MICCCAGGG ACTCTGTAGT GGAGCCAAGC TAGAAAGCAG AGGCAAGTGG GCTGAGCAAC ACCTAAGGAG GAAGCCAGAC TGAAAGCTrG GT7CCrrGCA 1TT7GCTCTGG CAT=~CCAG AGTGCAAATr TCCTACCAAG GTAATGAGGG TAGAGGAGAG AAAGAAGCTC ==c~CCCC TGATTCTCAT TCCTGAAAAG ACGGT-rGGTC CTITAAAA F7C CATGGATGTA GATCTTATCC CCACACCCAG ATrCTAGTCC TCTGGAGATA AAGAAGACTG CTGGACACTA ATGTATCCTC TCTGGACTT TGCAGCTCCA GATGGCGTGT TAGCAGGTGA GTCCTCTG'Fr CTrGTTCCCT TGGTGTATCA ACATGTCTGG GCATTGCTI CCTCTCACTA 'f==~CGT CCCATCACTT CTGCT=CTA ATGAGCATGA ATCTGT7CCT TGGCCAGACT A=TCCCTC TCCACCTTGC MIGTC'=C TIrI=CCC TGATTCAT7G CAT7rCTCA AGTCATTCTC TCCTCTGTI TAGTCAATAA CCATGTCTGT TGCACATATA CATGTCTCAT TCTCTCTCCT AGACACTIG GCATGATCTC GCTCAATAAT TACAITAUTA T'rAT7ATrGC CATITATAA 'FrGAGGATGC TGAAACTCAG TGATITCTG GTGGTTACAT GGCTAAGGAA CTGGATITCA ACGTAAG FTC CTTGGATCTA AGTCCAGflC TCTCGACT ATATCACCCT T7GIATCA CCATGTATCT AC=C'=GG TCrCTGTrCA AAT'1TGCACT ACATCCCC= GTTCCAGGAA GCCATTCAAG ACTGACYIC 7TAGTGCCTC TCACTACT= CTGGAACTGA CATATG=~T TCACTCrGTA TATACTTACA A'I1TAAATAGT CATAAATATTr CAGAGCTGG AGAAACCTTA TATrCATCC AGTCCAGTAA A'FrrATCCAT CCATAAT[7CA CTCAT7CATT CACATAATAA ATA'TI7AATG TAACAATGGT TGAACATGGC AGACAGTGrT7 TCTACCTCAA AAGAGAT17GC AGTCCTCATr TACAGATACT GAATTGAAAT TAACAGAAGT AGAGTGAGTC AGCTCAAATC ACATAGTGAA 'FrGGTrr7rI TGT1TTAAA TCTCCTGCAT ATGTGTCCTG TCTFCTCCC TGTGTTGGGC GTrCCCTGGG GCACCAATAC TAAITCTCC TrCCCCTAGA AATCAAAACA GGGTCTTATC ACCAACAGAA TAAGGACAGG TI7GACCACTG AJFTGTCAGAA TATrGCTTCG 'TTGTAC=r TAAGCCTAGA CAGTITCAA TGAC1TrIT TCTCTCTACA TGTCTITCA TA1T1TATC TTCTrGAAGT CCCTCAGAAA CCTAAGGTCT CCT7GAACCC TCCATGGAAT AGAATATI7rA AAGGAGAGAA TGTGACTCTT ACATGTAATG GGAACAATT C1TGAAGTC AGTrCCACCA AATGGT7CCA CAATGGCAGC C=rCAGAAG AGACAAATTC AAGTIGAAT ATrGTGAATG CCAAAT7GA AGACAGTGGA GAATACAAAT GTCAGCACCA ACAAGTTAAT GAGAGTGAAC CTGTGTACCT GGAAGTCITC AGTGGTAAGT TCCAGGGATA TGGAAATACA GATCTCTCAT GTGAGGGATG GCTCATCTGA AGATGGGAAA AAACAGGTTA 'ITCCAAGGGT TAGGACACCA GAGTGGGA'T CAAGGCCTCT CATIT=AAG ACCCCTGCAT TGGCTGGGCA CAGTGGCTCA CGCCTGTAAT CCCAGCACTT TGGGAGGCTG AGGCAGGTGG ATCACGAGGT CAGGAGATCG AGACCATCCG GCTAACATGG TGAAACCCCA TCrCrGCTAA AAAATATATA TATATAAAAT TAGCCGGGCG TAGTGGTGGG CACCTGTAGT CCCAGGTACT CGGGAGGCTG AGGCAGGAGA ATGGTGTGAA CCCAGGAGGT GGAGGTTGCA GTGAGCTGAG ATCACGCCAC TGCCCTCCAG CCTGGGCTAC AGAGCAAGAC TCCGTCTCAA AAAATAAATA AATAAATAAA AAAGACCCCT GCATCTCTT TCT7CTACCC CCTTCC='~ TGAT7ACTTG TATGCCTTCT TTCAATA F7C TAGTCATCTC TCAATATTAT TCCTCCACCC TA=hCCTC TATCIT1CT GCCTAGATTC AGGTATATAT TATGTGGTCA AACAGCATGA CATATATGTG AACAITT7CAA AGAGCTGTGT ATCTGGAATA GGATCAAAAG Gn7~GACTrA AAGT1TGCT CTGCATAATC CATATGGCAG GACCTGAATA TrAGGTTGTA CT=TCG~rA TGAAACATAT CTGGGTACAT TTCCTTATGT CCTCTGT7GT TAC7FAAGAA CACATAITITC ATGMIGMT CATIT=ATC ACTCCTACTG CCAACAAATA GCATAGCATG C17AGGCACA TGTGGCTTAA 'FrAGCAAATG 'TTGAATAAAC AAATrAATGA =ITGAATAG TGACCAATAG GTCTCT1TTA TACTCTATAT 1TICTCT-rG AGTGAAAAAA AATG71TCAA CCTCCATATG TAAAT7CCAA ACACAAACTA AAGCAATGTA GAATAGCTTC ITCCCTr GGAGTAGG'Fr CTAGAGAAGT CCTAAAGGAT TGGTCCTAAA T7AATrATGC TFATTATGCT AGCGATATI CCI=CAAAA 'ITCrCCI=A ATGAATGCT 'IMAATTM ACAAAAGCAT TAACCATAGA ATGTGA'TC TGTCTTrCAC TGACTCATTA GTGACAAATA 'FITGTFGAGT ACCTACCAAC TCCTAAGTAT TGCTACCAAC TCCTAAATAC TGTGTTGGGC ATrCAGAATA GAATGTAGAA CTAGACAGGG TCCCTGACIT CT7GGAGCAC AGAGCAGTAT GGGAAGAGGA CATTAAATAA AGAATTACAT AAGTAAT[AA ~TAAATrAT ACATG=IIG AAGAAGTI= TITFGACAA CTATAATTAA CACTAGAACT GGGAAGTI7C TATAAGGTAA GAGAGGACAA AATAGACACT CTCCTAAGCT AAAATI'CCCA AGAAAGACTG T~A I=CC CCTAACTAAC TAGAACTAGC AACAGAAGAT CTGAAAGGAA TITCTGG='~ CAAGTGTTCC ATGTATGGAC TCATCAGGGA GGTCCGAGAG GCTTGTGGC CCCAGACTGA UlI I ICAGGA GGGGAAAGGA 1TATCAATA WO 00/09525 PCT/US99/1 7712 EPI-10911 CACAAGACAG GCTCTAAGCA TITA=fGTG CCC1TTAAAA ATCCA=rrA TGAGCCAAAA AGTGAGTTAA TGATAATrCA TAG2TT'CTGA CACATGCTCT ATGCGTGGCT CTCT1TCTC TATrCATTCT CTCTrCrC A ITATTGtT AAATAAATAA TGTAATGAAT GTrCTrCAGA CTGGCTGCTC CTTCAGGCCT CTGCTGAGGT GGTGATGGAG GGCCAGCCCC TCTCCTCAG GTGCCATGGT TGGAGGAACT GGGATGTGTA CAAGGTGATC TATrATAAGG ATGGTGAAGC TCTCAAGTAC TGGTATGAGA ACCACAACAT CTCCAUrACA AATGCCACAG T7GAAGACAG TGGAACCTAC TACTGTACGG GCAAAGTGTG GCAGCTGGAC TATGAGTCTG AGCCCCTCAA CA'ITACTGTA ATAAAAGGTG AGrrGGTAAA GGAAAGGAAA AGCATCCATA GCAGGGGAAG GAAGAGAGAA CT7CTGAGCC TGAGCAGTrG CAGCTrGTAG AAGGGGGGCA CCTGTGATAC ACTcIGAAAGC CTACCAGACT TGCAATGAGG AGACCTGGGT GATAGTATAT ATCTCAATCT CTGMfCAAA GCCTTGACTT GTrAAATGGT GATAGTAATA CCTGCTTGCA CTATGAAAYr TTrATGAAGA TITAATGTGGT AATAT7GTG AAATGAC1T GTAAACTGTT AAGCACTACC CAAGCATAAC AGATrGTGAT TACTATMTG ATCTCAAAGT CATCTGTFGC TCCTGGGGGA ACAC=ATAT TrATCAAATr GAAAAAAAGT 7FrCAAAG11?G AATGAAGAAA GGATATAAAG AGCTIGAGGA GCCCA1TCCA GC'ITAGGAGG GCTGGGAAAG GAAACCAGCA AGTCAGTAAG CTGTGTGCCT GTGTAITGAG GGAGGAGGGA ATGGACTTGA TATGGAGAGG GTAGGGAGGT GGACTGCCTC TATGGCCTGT AAGAAAAACT GCTCTCTCCA AACTr=AT AAGAGAGGGA GCCTGTGAAG TATTCACTI TGAAGGAGAA AG FI2AGAC= TTCCTTrCACA CACITGTAC ATAATAATGT TAAAAAAGC ATGAGGTCAA AATACATAAT TAAGTCCTAG CAGTTCTCTG -frAACTAA'IT TGAGACTGAA GTGCTATGTA C=GTCTCTA GGCTTCCAGT ATCTFCATCT GTAAAACAGA ATA'ITTGGTC TAGATrCCAT TAGAATCA'IT TGATAACTTA AAAAATATAT TGATGCTCAT GTGTCATrC ITGAGATrCT GA TrTAATFrG GnI7GGGGTG CAGCCTGGGT ATACGTATTr TTFCATAGGTC MTCACATAA TGGTAATGGG TAGCCAATAT TGAGAATCAC TTGTCTAGGT GATC'=AAA TGA'ITrCTGG ATGTAATATT CTGAGGCTCT ATANITTTGAG ACTAATCACA AAAATCGGTA CAGMI~ATAA ACAGACTAAC AGAACCACAA AATAATAGAA rTGGAAGGCA A'IMAAC7AG TGCAATFr7CT TCAT1TGCC TAACAGGCAT GTAAGAAATG ATGATTGATT GAGTAATAGG CAT7GATGAC CCCTGTCCTC AC'=GTCCC CF=CCACCC CT[AATTATA TGTGAAT7CT GGTCTTGTCA TITCGAATAA GGGGTT7ATC '1CCTA1-rG TCTCCCCTC TGGGCACGGC ACACTGGCTA CTGGAGTFAA GAGGAAATGC TTAGGACTCC CTGTGGCTCC AGGGAGCACC AACAGAGCAA CTCAACCTAG TG~rAATCTG AGTGTTICT CTGTGCITCT GGATGCCACA TCACGCTAAA AATGAAGGAC AAAGCTTGGT CTICTCTrA GGGAGGATGA AACTCTGAAC CTCATITC AGTTCCCAAG ATGAATTATG '1CTCATrG CATCTGTGTT7 CCACTACAGC TCCGCGTGAG AAGTACTGGC TACAATL= TATCCCATrG TrGGTGGTGA T-FCTG~TT7GC TGTGGACACA GGATrAMrA TCTCAACTCA GCAGCAGGTC ACATITCTCT TGAAGATTAA GAGAACCAGG AAAGGCT7CA GACTTCTGAA CCCACATCCT AAGCCAAACC CCAAAAACAA CTGATATAAT TACTCAAGAA ATATI1GCAA CATrAG=II 'ITCCAGCAT CAGCAAT7GC TACTCAATrG TCAAACACAG =TGCAATAT ACATAGAAAC GTCTGTGCTC AAGGATITAT AGAAATGCT'r CATTAAACTG AGTGAAACTG G FTAAGTGGC ATGTAATAGT AAGTGCTCAA TITAACATrGG 'I1GAATAAAT GAGAGAATGA ATAGA ITCAT TTATTAGCAT 77FGTAAAAGA GATGTrCAAT TrCAATAAAA TAAATATAAA ACCATGTAAC AGAATGCTTC TGAGTATrCA AGGCTTGCTrA GTTG'TIGT F7GT=CTA CTAAAGGCAA GGACCATGAA GTTCTAGATIT GGAAATGTCC TCTCTrGACT AUrGCAAGTG CGATCTAGGA ATGAAAAGAC ATAGGAGGAT GCCAGTGAGG TGGATCA'ITr 7rATG=~CT TCTCAGC'Ir ACTAAATATG AACTICAGT TCTrGGCAGA ATCAGGGACA GTCTCAAGAC ATAGGACTCT CAGGATGAAG TAGAGTCCAG GATrCCTCTG TGATTG=I~ GCCCCTCCCA AA ITATATC TFGAACT7AT GTCT1rGTATC T'IrATACAGC ACCTGAACCA AGCATITGG AGAAATrCCA GCTAATAATA ATAACCAAAA CCTTCGGCTC TGAAAACAGT CCAGGACTGA ATAAGATCTr GGGCAAAAGA ACTAGACAGT TrGGTrAT TITCC='~C ATITATGTC TrCATCATAG TCAT7GGAGG CTCA7TCTTC TTGTCATGGA GTAAATGGGA 7rAAAGT7C TACTAAGAGT CTCCAGCATC CTCCACCTGT CTACCACCGA GCATGGGCCT ATA=IIGAAG CCTrAGATCT CTCCAGCACA GTAAGCACCA GGAGTCCATG AAGAAGATGG CTCCTGCCAT GGAATCCCCT ACTCTACrGT GTGTAGCCTT ACTGTrTMC GCTCCAGATG GCGTGTrAGC AGTCCCTCAG AAACCTAAGG TCTCCTTGAA CCCTCCATGG AATAGAATAT TTAAAGGAGA GAATGTGACT CTACATGTA ATGGGAACAA 'IrCI=GAA GTCAGTTCCA CCAAATGGT7 CCACAATGGC AGC='~CAG AAGAGACAAA TrCAAG'TrG AATATrGTGA ATGCCAAATr TGAAGACAGT GGAGAATACA AATGTCAGCA CCAACAAGTr AATGAGAGTG AACCTGTGTA CCTGGAAGTC TrCAGTGACT GGCTGCTCCT TCAGGCCTCT GCTGAGGTGG TGATGGAGGG CCAGCCCCTC TI'CCTCAGGT GCCATGGTTG GAGGAACTGG GATGTGTACA AGGTGATCTA TTATAAGGAT GGTGAAGCTC TCAAGTACTG GTATGAGAAC CACAACATCT CCATI1ACAAA TGCCACAGTT GAAGACAGTG GAACCTACTA CTGTACGGGC AAAGTGTGGC AGCTGGACTA TGAGTCTGAG CCCCTCAACA FrACTGTAAT AAAAGCTCCG CGTGAGAAGT ACTGGCTACA A~IrrATC CCAT7GTTGG TGGTGA'rTCT GTT7GCTGTG GACACAGGAT TA'IMATCTrC AACTCAGCAG CAGGTCACAT TTrCTTGAA GATTAAGAGA ACCAGGAAAG GC1TCAGACT TCTGAACCCA CATCCTAAGC CAAACCCCAA AAACAACTGA TATAATTACT CAAGAAATAT ITGCAACATIT AGTITITIC CAGCATCAGC AATTGCTACT CAATrGTCAA ACACAGCT7G CAATATACAT AGAAACGTCT GTGCTCAAGG A'TrATAGAA ATGC1CATT AAACTGAGTG AAACTGGrI'A AGTGGCATGT AATAGTAAGT GCTCAA FrAA CATTGGTFGA ATAAATGAGA GAATGAATAG ATrCA'I=AT TAGCATITGT AAAAGAGATG TTrCAATrCA ATAAAATAAA TATAAAACCA TGTAACAGAA TGCTTCTGAG TAAAAAAAAA AAAAAAAAAA AAAAAAAA TCTCAATATA ATAATAT7CT 7rAT7CCTGG ACAGCTCGGT TAATGAAAAA ATGGACACAG AAAGTAATAG GAGAGCAAAT CTTGCTCTCC CACAGGAGCC TrCCAGTGTG CCTGCKTG AAGTCrrGGA AATATCTCCC CAGGAAGTAT C'ITCAGGCAG ACTAT1TGAAG TCGGCCTCAT CCCCACCACT GCATACATGG CTGACAG'IM TGAAAAAAGA GCAGGAGT7C CTGGGGGTAA CACAAATTCT GACTGCTATG ATATGCC1T G=IGGAAC AGTTGTCrGC TCTGTACTrG ATAI7CACA CA17GAGGGA GACATTIT CATCA IMAA AGCAGGT7AT CCATTCTGGG GAGCCATATr 1T]TCTAT7 TCTGGAATGT TGTCAATTAT ATCTGAAAGG AGAAATGCAA CATATCTGGT GAGAGGAAGC CTGGGAGCAA ACACTGCCAG CAGCATAGCT GGGGGAACGG GAATTACCAT CCTGATCATC AACCTGAAGA AGAGC77GGC CTATATCCAC ATCCACAGTT GCCAGAAATT =1TGAGACC AAGTG='TA TGGCTFCCTT TTCCACTGAA ATrGTAGTGA TGATGCrGTT TCTCACCA Fr CTGGGA~TTG GTAGTGCTGT GTCACTCACA ATCTGTGGAG CTGGGGAAGA ACTCAAAGGA AACAAGGT7C CAGAGGATCG TG'IMATGAA GAATTAAACA TATATrCAGC TACTlACAGT GAG77GGAAG ACCCAGGGGA AATGTCTCCT CCCATrGATr TATAAGAATC ACGTGTCCAG AACACTCTGA 'ITCACAGCCA AGGATCCAGA AGGCCAAGGT CTTGTTAAGG GGCTACTGGA AAAA'I7rCTA 7rCTCTCCAC AGCCTGCTGG =IP AAGC'r=CA AAGGTGCAAT TGGATAACTT CTGCCATGAG AAATGGCTGA A17GGGACAC AAGTGGGGAC AATI1CCAGAA GAAGGGCACA TTCrrrC= TrCTGCAGT7 C'IrTCACC TTCTCAACTC CTACTAAAAT GTCTCATIT CAGGT7CTGT AAATCCTGCT AGTCTCAGGC AAAATTATGC TCCAGGAGTC TCAAAI=rC TTA'IMCATA TrAGTC'=A 'rMAGTAGAC TrCTCAMTr TrCTAT7CAT CACAAGTAAA AGCCTGTTGA TC'TAATCAG CCAAGAAACT TATCTGTCTG GCAAATGACT TATGTATAAA GAGAATCATC AATGTCATGA GGTAACCCAT TTCAACTGCC TAT7CAGAGC ATGCAGTAAG AGGAAATCCA CCAAGTCTCA ATATAATAAT AITr=A~r CCTGGACAGC TCGGTrAATG AAAAAATGGA CACAGAAAGT AATAGGAGAG CAAATC=GC WO 00/09525 PCT/US99/1 7712 tYi-109 112 TCTCCCACAG GAGCM~CCA GGTAGGTACA AGGTATTA'Fr TIThCTACC CTCAGTCACT TGTGGCAGGG GAAGTCATAG TCACGGTGCT TAGGAGATGA AAC=ATrTG A TrAGGCAT GGATCCATCT AGTTrAATTA ATATATTGGG TATGAGGAAG CTAC'TrGCTG TAC1TCCAT GTGG FTCTCT CTCCCTGGAG AGciAACAI7r TTACTCAGCT TGCAAACTGG AAATAGATTT TCTCACATTA GAAGCTCA'PT 7rCTGGGTAT GAGACAGGAG AGTTCATACT GTGTATGTAG ATCTCTGGCT TCTGGGTCTG ACATGTGCTG AGGGACACAT ATCCT7CACA CATGCT1TA TAAATACTTG ATAAAGTAAC CTG=~CTTG Ai7GGTCIT ATAATCCATA AGCTGTGGGA TGC~T7CT~G AAGATGAAAA TAGTAATAGA GTCCCATCTA GCTNI1TCAAA GCCATrCCTT CATTGTATTC TGTGCACATG AAGT'rGGGGT FrGTTACTGA CAAAATATAT TCAGATACAT flCTATGTrA AAAGGATTGT GAGATGCATA GGTAAATGTG 'IMAITrCA GTITACTrG TCAACATAGA TGAATGAGAA AGAACTTGAA AGTAACACTG GATI'AAGAAT AGGAAAATFr GGCATGGAT7 TrGCTCCA'Tr TrGTCCCATC TAATCACTrG GATAGTGT~rC AGGTG FrCIT GGTCAGT'rAC rTGGATGCT'C TGAGCITAG =TCTTGGTG ATFTACAATGA AGATTrGAAT TACAGGATGG CTPGAAAAA ATAAACAAAA CTCCCCITC TGTCTGTCGA GAATGTTGCA CAGGGAGTFTA CAGAATG'T7C TCATGACTGA A'FrGCTI=A AA I=CACAG TGTGCCTrGCA T1TGAAGTCT TGGAAATATC TCCCCAGGAA GTAT=TCAG GCAGACTATT GAAGTCGGCC TCATCCCCAC CACTGCATAC ATGGCTGACA GTI=GAAAA AAGAGCAGGA GTTCCTGGGG GTGAGTGAGC CTCCTCCAAC TTrGACTAGA GTAAGGGTTG GGTCTAGAAA AGAATATFGA GTrGCATCAA CTG IICCC ACTGGATTC ATGAGAGGTG TTAGGTCCT'r TAAAAAACAT GGTAGATAAA GAGTI'GACAC TAACTGGGTC CTITGGGAA GAGCCAGAAG CA=TCCTCA TAAAGAC'r AAATGCT7AG GACGAGAATG GCCAACAGGA GTGAAGGAT CATAACT1A TC=rA=~A GATGTAAAGA ACAA FrACTG ATGTrCAACA TGACTACATA CATAAAGGCG CATGGAGAAA AGTAflrGGCC TTCCATGCAT TAGGTAGTGC T7GTATCAAT TCTrATAGTG GCTAGGGTAT CCTGGAAAAT =TACGTGTG GATCATrCT CAGGACAGTC TAGGACACTA ACGCAGTTrC TCATGT-17GG CT1CTATrAT TAAAAAATGA TACAATCTCG GGAAAATIT T11XA=FC ATGAAAT'TCA TGTG'TI=C TATAGGTAAC ACAAATTCTG ACTGCTATGA TATGCC'lI I G TITGGAACA GTTGTCTGCT CTGTACTTGA TATTCACAC AT7GAGGGAG ACA'TITI1C ATCA=~AAA GCAGGT7ATC CATTCTGGGG AGCCATATT7 GTGAGTATAT ATCTATAATT GTITCTGAAA TAACACTGAA CATAGGTIT TCT='~CTC AGATCTAACC AGrGT'17AT TCCCAGTA77 AAGATGATAT TTATAAT-rCT TAATrATAAA TATATGTGAG CATATATAAC ATAGATATGC TCATTAACAA CAACAAAAGA TrCTITIAC AATTAACGGT GGG'ITAAACA 'ITAGCCCAC AG=ITATCC CATGAGAAAC CTGAATCTAA TACAAGTTAA ATGACTFGCC TAAGGGCCAC TTGACTAATA GTAATTGAAC CTAAAC1TC AGAATCCAAC TCCAGGAACA TAC'FCTAGC ACTAT[CATC AATAAAGTA TATGATAAAT ACATACAACT T-rATCTGTCA ACTAAAAATA ACAACAGAGG CTGGGCATGG TGGCTCACAC CCGTAATCCC AGCACIIGG GAGGCTGAGG CAGGTGGATC ACCTGAGGTC AGGAG'ITTGA GACCAGCCTG ACCAACATGG TGAAACCTCA TCTCTACTAA ATATAAAAAA TTAGCTGAGT GTGATAGTGC ATACCTGTAA TCCAGCTACT TAAGAGGCTG AGGCAGGAGG CTTG'I-rGAA CCTGGAAGGC AGAGGTFrGCA GTGAGCTGAG ATrGTGCCAT TGCACTCCAG CCTGGGCAAT AAGTGCGAAC TCTGTCTCAA AATAATAATA ATAATAATAG AAAATAAAGT TGTCTrCATG AAAAATGAGG AAAGAGATTG CTGGGGTGAG AAACATTAAG ATCAATGGGC ATATGGTGAC CTCTATGCC CrAGAAACTC TIJANGGTA =1ICTCCTG GTATCTCIT TACNCATCGT TCTATCTGGA AAAATAGGTG GATGAGTGAG ATAATAACGG TATATAC'TI TrAAAGGTCT AA'ITGACATA TATAAATrGC AAGTAnITCA GATGTCAAT7 TGCTAACCTT GACACACATA GACACACATG AAAACATCAC CACA'ITAATA CAATGTATGT ATCCATCA F[ CCAAAAGC= CCCTGTGTAT CTIGTAACT CI=CTrTCCT CCCTCCACTC =TGTCCTCT CGTrCCCAAG AAAACATTGA TCTGCITCCT GTGAATATAA ATTAAC1TAC ATTAGA GCT'ITATATA AGTATGTrCT CITACTGTr TGTCTrCCTT CGCTGCACAG TTAT1TGAG ATTcT~rCAAG IT==rl~ ATATCGATAC FrCATTCACA AGAATATATT 17AATrCTAG ACTATGTCAC ATTGA=TTG TCGTCTGCTA AATCC11rAGT GCTCAGATGA =~GTrCAGG ACTCTCCTG AACCTGTACC TCTGTrANAT TGAAAC1TGT CTCTACTGTC r-I=rAMC AAACACAGCT TATrAGGTGT CTCT-CAACCC ATCAAACNCA CAATCTGAGT CTTAGGAGA 11'GCTGAA T1TGTGCTAT TGACTI'ATAT NTATATNAAA TNTGTAAATG TT7GGTAAAA ATATCATCAT GTACN'T=rC ATAATrACGC TATNTNCACA TGATATATGT CAGACTCTGG AAATATGCAT GCCACAGACA CGTG'TrC7r GCCTAAAGGG GCTGATGGAA GACNCACATA CNAATAGACG ATrGCAGTAG AATGAGAGTG GTGGTCTAAN CAGTACATGT CCTGATGflG CTCGGACAGT TACTACNCCA AGAGTACCCC CTGCATrGTC AGGGPTAGCA TCTCCTGGAA GCCTCATGTA AATGAAGAAT 'FrCATGCTCC ATCCAGGACC TAATGAATAA GAATCTGCAT 71TAGCAAGA CCCTCATATG ATTCATATAC ACTTITFF TTITFl=A GATGGAGTCT CACTrCTrGTC GCCCAGGCTG GAGTGCAATG GCATGATCTI' GGCTCACTGC AACCTCTGCC TCCCGGGTTC AAGTGATrCT CCTGTCTCAG CCTCCCTAGT AGCTGGGACT ACAGGTGCAT GCCACAGTGG CTGGCTAATT T"ITGTAT1T TAGTAGAGAC AGGG'IMCAC CATITGGTC AGGCTGGTCT TGAACTCATG ACCTCCGGTG ATrCCCCCGC CTCGGCTCC CAAAGTGCTG GGA'TTACAGA CATGAGCCAC CACACCCGCC TTATTCGTAT ACNCAnflAA TTCTGAGAAG CACTCTATAG AAAATAAGAA TAAGAAAATA TrGGGCTCAC AGGTGACATT AATAAGTAAC TIATCGAGT ACCCCAAATT TTACCTATGT TrGGAAGATG GGGT'rAAAAG GACACATTGA AAACAAGAAC TCATrGTGGC FTTMCC TCC1I-rGA ACAGTITCT ATf7CTGGAA TGTTGTCAAT TATATCTGAA AGGAGAAATG CAACATATCT GGTGAGTrGC CCGnI7CTGT C1TGTCCAT CCTrGAAAAG ATAAGAAGAA CAGAG=I~A AGAGTCTAA GGGAAACACA TC'TGTCTC CTATATTACT TGTGAATGTG GATATATGAT MrGnFICAA TCTATTTGT GTCCTAAGGC 'mTGCAAC AGAAG~FrGGA TATATCATX'A GAAACATAAA TrGTACCAT7 TAACATACAT GAAGTITATG 'ITrACCTrGA CGTrCT7CTA AAAAGTGTCC TACACCGGCA TTGTC=TGT AGGCATAFTC ACATGATCAA ATAAAATAAT TAG=ITCAA TTAAGGAGAA TATrTGAGGA AAGACCGTAC GTGTTCATGT GGTrrCCTGAA GGCAGTCCAG TGAGAAAGTA ATATATGCY7 CATTAAACAA TGCGGACATT 'rTCAGGG=T CCCTITIAA CCAAAA'ITTG GAAGCAATGT GGAAMIACT GGATGCATCC AGCCCTGAAA TGAAGATAGG 'I=ATrGAAT GTGCCAGCAA GTGCAGGCCC AGGTCTGAGT GTrCTTCAT7 APTATCAGGT GAGAGGAAGC CTGGGAGCAA ACACTGCCAG CAGCATAGCT GGGGGAACGG GAATTACCAT CCTGATCATC AACCTGAAGA AGAGCTTGGC CTATATCCAC ATCCACAGTT GCCAGAAATT ITTGAGACC AAGTGCTIA TGGCTTC T rCCACTGTA TGTATTT 'I=GTGTGGG AAGACTAAGA I1CTGGGTCC TAATGTAAGT AAGAAGCCCT CTTCTCCTGT TCCATGAACA CCATCCTIT CTGTAA=TC TATTrACACAG TATAGTGGT7 CTGTAAGTrC ACACAGCCCA GGGAGATGCT GGCTGCCCAC TCCCCTCAAC CCAGGCAAAT TCCTCGGGGT TAAAGT7ATC TACTGCAAGT GACGATCTCT GGGTTMr GTGCCTGTGT TTGTGTGTGT GTGTGTGTGT GTGTGTGTGT GTATGTGTCA C1TAAAAGG ACTGGTCAGA TGGTAGGGAG ATGAAAACAG GAGATGCTAT AAGAAAATAA AC'T1TGGGG CGAATACCAA TGTGACTCI TnTGTTrGTC ATrGTrGCT GTrCAATAGG AAATTfGTAGT GATGATGCTG 'ITI'CTCACCA TrFCTGGGACT TGGTAGTGCT GTGTCACTCA CAATCTGTGG AGCTGGGGAA GAACTCAAAG GAAACAAGGT AGATAGAAGC CCGATATAAA ATC=GAATG ACAGGTrAAC GAAT7GGAGC rATTCCTr AAAATATGGC CTGGGT1TC TGAAACA=l~ CTI'CCAGAAA ATAGTIT7CTC CAAGTI=AT TACTITGGIT TACAAATCTC ACATTTAAAT CACAITIAT ACCATAAGTA GCACACATrr CATAATA7]?C CTCTGAATGA GGGTI1GGGAT AATAGGACTG ATATG ITAGA AATGCCTTAA AGTGTGTGGA GCATGAGAGA TGGATGTACA WO 00/09525 PCT/US99/17712 EPI-109 113 GAAGGCTTGT GAGGAAACCA CCCAGGTATC TGGCCTTGTT T7CTGCCCCA GAACTAGCCG CCTATrCCTG mTCTGTrT ATTCCTTGT TTCTTGACTT TTCCTTTCCA ACTTGCTCTA AAACCTCAGT TTTCTCCT TTCTGATTCA TGACTACCAA ATGT=TTCAC TTGCCTCACC CGTCCATTAC ACCTGATA AGAACCACCA GACCTTGTGC TCATGTACTT GCCCATGTCT GATGGAAGAA ACATACTCTC TCCATCTGTC CACTTCCTG AGGCATTCAA GTCTAGCCAC CTITTAAAAT CACTCTCCTC CAGGCTGGGC ACGGTGTCAC GCCTGTAATC TCAGCACTTT GTGAGGCTGA GGAGGGCGGA TCACTTGAAG TCAGGAGTTC AAAACCAGCC TGGCCAAATG GCAAAACCAA ATCTTCTTCA ATTATAACCA AATCTTAAAC CAAATCTCTA CTAAAAAATA CAACAAAACA AAACAACAAC AACAAAAACA GAAAAGGAAA CATTAGCCCA GCGTGGTGGC AGGTACCTGA GGT7CCAGAT ACTTGGGAGG CTGAAGCAGG AGAATCGCTT GAGCCCAAGA GATGGAGGTT GCAGTGAGCC GAGATCATGC CACTGCACCA CAGCCAGGGT GACAGAGCCA TACTTCCCAG CACATTGGGA GGCCAAAGCT GAAGAATAAT TTGAGGTGAG GATGGAGA CCAGCCTGGC CAACATGGTG AAACTCCGTC TGTACTAAAA ATATAAAACT TAGTGGGGCA TGGGGGCACA CACCTGTAAT TTCAGCTACT TAGGAGGCTG AGGCAGGAGA ATTGCTl'GAA CCCGGGAGGC GGAAGTrGCA GTGAGCCAAG ATCGTGGCCA CTGCACTCCA GCCTGGGTGA CATAGTGAGA TTCTGTCTCA AAAAAAATAA AAGAAATTTA AAAAATCACT CTCTTCCAAA GATAGATAAA TAAGACAGCA GATATACTAA GGAATAACCT CACCAACTTG TCATTGACTG ACATGATC TTGGCCCA CTTGGCCAGC TAGTCTGGTT TGGTTCTG GAAATGAAAG AAATAATCAG AGTTTAATGA CAGAGAGCGT GAGACCCAGA AAGACAAAAG TAGATGAGGT AAGTCTCTTG AGCGAGACTT CTAGGGATGG GAAATTGTG GTGATTGATA TGAAATGATT TTTCCCTTAT CAGGTTCCAG AGGATCGTGT TrATGAAGAA TTAAACATAT ATTCAGCTAC TrACAGTGAG TTGGAAGACC CAGGGGAAAT GTCTCCTCCC ATTGATTrAT AAGAATCACG TGTCCAGAAC ACTCTGATTC ACAGCCAAGG ATCCAGAAGG CCAAGGTT GTTAAGGGGC TACTGGAAAA ATCTATTC TCTCCACAGC CTGCTGGT'TT TACATTAGAT TTATTCGCCT GATAAGAATA TFTIGTTTCT GCTGCTCTG TCCACCTTAA TATGCTCCT7 CTATTTGTAG ATATGATAGA CTCCTATTT TCTTGTTTA TATTATGACC ACACACATCT CTGCTGGAAA GTCAACATGT AGTAAGCAAG ATTTAACTGT TTGATTATAA CTGTGCAAAT ACAGAAAAAA AGAAGGCTGG CTGAAAGTTG AGTTAAACTT TGACAGTTTG ATAATATTMG GTTCTrAGGG TTI11 TTTTAGCATr CTTAATAGTT ACAGTTGGGC ATGATTTGTA CCATCCACCC ATACCCACAC AGTCACAGTC ACACACACAT ATGTATTACT TACACTATAT ATAACTTCCT ATGCAAATAT TTTACCACCA GTCAATAATA CAIT1liGCC AAGACATGAA G1111ATAAA GATCTGTATA ATTGCCTGAA TCACCAGCAC ATTCACTGAC ATGATATTAT TTGCAGATTG ACAAGTAGGA AGTGGGGAAC TATTAAG TTACTCGTTG TCTGGGGAGG TAAATAGGTr AAAAACAGGG AAATTATAAG TGCAGAGATT AACATTTCAC AAATGTTTAG TGAAACATTT GTGAAAAAAG AAGACTAAAT TAAGACCTGA GCTGAAATAA AGTGACGTGG AAATGGAAAT AATGGTTATA TCTAAAACAT GTAGAAAAAG AGTAACTGGT AGATTGTT AACAAATTAA AGAATAAAGT TAGACAAGCA ACTGGTTGAC TAATACATTA AGCGTTTGAG TCTAAGATGA AAGGAGAACA CTGGTTATGT TGATAGAATG ATAAAAAGGG TCGGGCGCGG AGGCTCACGC CTGTAATCCC AGCCCT=TGG GAGGCCGAGG TGGGCAGATC ACGAAGTCAG TAGTITTGAGA CCAGCCTGGC CAACATAGTG AAACCCCGTC TCTACTAAAA ATACAAAAAA AAAATrAGCT GGGTGTGGTG GCAGTCACCT GTAGTCCCAG CTACTTGGGA GGATGAGGCA GGAGAATCGC TTGAACCTGG GAGGCGGAGG TTGCAGTGAG CCGAGATCGC ACCAGTGCAC TCCAGCCTTG GTGACAATGG GAGACTCCAT CTCAAAAAAA AAAAAAAAAA AAAAAAGATA AAAAGTCAGA AATCTGAAAA GTGGAGGAAG AGTACAAATA GACCTAAATT AAGTCTCATr TTGGCTT GATTGGGG AGACAAAGGG AAATGCAGCC ATAGAGGGCC TGATGACATC CAATACATGA GTTCTGGTAA AGATAAAATT TGATACACGG TTTGGTGTCA TTATAAGAGA AATCATTATT AAATGAAGCA AGTTAACACT CTAAGAGAAT TAl-11-GAGA TAGAAGTGAA GCTAAGCTAA ACTTCACATG CCTATAATTG GAGGGAAAAA CTAAGGATAA AATCTAGCCT AGAAGATACA ATAATTAGTC ATAAACATGC ATTGTGAAAC TGTAGAGAGC AGGTAGCCCA AAATAGAGAA AGATTAGATA AAGAGAAAAT AAGTATCCAT CAGAGACAGT ATCTCTAGGC TTGGGCAAGA GAAAAGTCCA CAGTGATAAG CAACTCCACC TAAGGCATGA ATATGCGGCA GAGAAAACAG CAATAGTGAA TGAATGCAAA AGGTGCTGAG CAAATTCCAC ACATGAGTAT TGTGCATGAG TAAATGAATA AAACATTTGC AAAGACCTTT AGAGAAAGAG AATGGGAGCA TATGTGCGAA ATAAGATAGT TGATrATGAA TAGAAGGTAG TGAAGAAAAG CAAGCTAAGA AAAAATrCTG TTTATAAAAG AAGGAAAAGA TAGTTTATGT TTAGCCTA AGTATAAGAG TCCTACAGAT GGACTGAAAA AAATCAGTCT GAGAGTATTA GTCACAATTA ATGAAATAAT TACATITrAT GTATTGAGGA TGCCAAGATT AAAAGGTGAC AGGTAGATGT TAATTTCCCT AGATTGTGAA AGTGATCACG ACAATCACAC AACAAATAAT TAAGTGACTT GGTATGCTTT ATTTAATTGT AGGGCCTGAG GTTTTCCATT CTCATITiTC TAAAATACAA TTFGTTrCT CCAAATTGA CAGCAGAATA AAAACCCTAC CCTTTCACTG TGTATCATGC TAAGCTGCAT CTCTACTCTT GATCATCTGT AGGTATTAAT CACATCACTT CCATGGCATG GATGTTCACA TACAGACTCT TAACCCTGGT TTACCAGGAC CTCTAGGAGT GGATCCAATC TATATCTA CAGTTGTATA GTATATGATA TCTC1111AT TTCACTCAAT TrATAITITC ATCATTGACT ACATATTTCT TATACACAAC ACACAATTA TGAATITrT CTCAAGATCA TTCTGAGAGT TGCCCCACCC TACCTGCCTT TTATAGTACG CCCACCTCAG GCAGACACAG AGCACAATGC TGGGGTTCTC TTCACACTAT CACTGCCCCA AATGTCTT CTAAATTTCA ACTTCAATGT CATCTTCTCC ATGAAGACCA CTGAATGAAC ACC111ICAT CCAGCCTTAA T'CTrGCTC CATAACTACT CTATCCCACG ATGCAGTATT GTATCATTAA TTATTAGTGT GCTTGTGACC TCCTTATGTA TTCTCAATrA CCTGTATMTG TGCAATAAAT TGGAATAATG TAACTTGATI TCTTATCTGT GTTTGTGTTG GCATGCAAGA TTTAGGTACT TATCAAGATA ATGGGGAATT AAGGCATCAA TAAAATGATG CCAAAGACCA AGAGCAGTT CTGAAGTCCT CC'I rMCATC AGCTCTTTAT CAAACAGAAC ACTCTATAAA CAACCCATAG CCAGAAAACA GGATGTAGGA ACAATCACCA GCACACTCTA TAAACAACCC ATAGCCAGAA AACAGAATGT AAGGACAATC ACCAGCCATC TTTTGTCAAT AATTGATGGA ATAGAGTTGA AAGGAACTGG AGCATGAGTC ATATMTGACC AGTCAGTCCT CACTCTTATT TACTTGCTAT GTAAACTTGA GAAAGCITT TrCTCTGT GAACCTCAGG TTACATCT GAAAATGAGA AA'TTGGAAC AAAAGATTCC TAACTGGTCT TTCTGTTCCC ATATTCTGTG A7TITICAAT ATTAGGAT ITTTGGTAATC ACAATTACTF AGThTGTGGT TGAGATAGCA ACACGAATCA GAACTATTTG GTGGACATAT TTTCAAAGGA GTAGCTCTCC ACTTTGGGTA AAGAAGTGAT GCNGGTCGTG GTGGCTCACG CCTGTAATCC CAGCACTTTA GGGAGGCCAA GGCGGGTGGA TCACGAGGTC AGGAGATCGA GACCATCCTG GCTAACACGG TGAAACCCCG TCTCTACTAA AAAATACAAA AAATTAGCCA GGCGTGGTGG CGGGCGCCTG TAGTCCCACG TACTCGGGAG GCTGAGGCAG GAGAATGGCA TGAACCAGGG AGGCGGAGCT TGCCGTGAGC CGAGATAGCG CCACTGCAGT CCCTCCTGGG CAAAAGAGCA AGACTGCGTC TCAAAAAAAA AAAAAAAAAA AAAAAAAGAA GTGTGTGGAG TAGCAGGACA CCTGCAACAA TAATATTTTT CTAAATCCCT CTGAAAAATG CTAATCAAAG GGTITITTC CTAAAAATTG TCTTAGAAAT AAAATTTCCC CTTGGGAGA CCGAGGCTGG CAGATCACGA GGTCAGGAGA TAGAGACCAC GGTGAAACCC CGTCTCTACT AAAAATACTA AAAATFAGCC GGGGNGTGGT GGTGGGTACA CCTGTAGTCC CAGCTACTTG GAGGCTGAGG CTGGAGAATC ACGTGAAC-3' (FRAG. NO:_)(SEQ. ID NO:2505) WO 00/09525 PCT/US99/1 7712 hPI-109 114 5'-AACAAGAAAA GCG7FGGTAG CTCTGGTGAA TCCCAAAAGA ATGTGGCAGT TGCTAGCCAT GCTCCTGAAT ATGTATAAAC AGTACATCAT ATGACTAAGA GTTTGACTTA GGGcYITAGAT '1TATGTGrFr TGAACCCCAA ATTAGTrATrr TAATAGUTGG CACCCCAAAA CAAGTTA=T AACCTCACTA AGGTTCAGT TrCCTGMIA TAAAATGTAG ATAGTGATAG TATGTACITT ATAGGATrAT TGTGAAAAAT AAATGAAATA TCAGATrAT TFrAGGATAAC ACCrGGCATA TG'I=GGTAT TCAGAAT7AG TrGCTGCTGT IMATTCrGC TCTCCCITGC ATCCCACTrr TCrAAGflGT AAACTAAATA GTrGTACACA GATrGACAGA ITAAGAAAGG CTGTGATrG TGCTAGACCT ATGCCTATGC CTCTGTCTCA CCAGATTCCA GGTGTATATG TGGAGGTGGG ATAGGGAGTG GAGTAAGTGG GTAAATKI1rA AATrGCCCAG T7GGGCACCA TCCTGAATAT TATCTCTAAA GAAAGAAGCA AAACCAGGCA CAGCTGATGG G~rAACCAGA TATGATACAG AAAACA I1rC CITCTGCTrr7 rrGGTM~AA GCCTATAT GAAGCCrTAG ATCTCTrCCAG CACAGTAAGC ACCAGGAGTC CATGAAGAAG ATG-3' (FRAG. NO:_)(SEQ. ID NO:2500) 5'-GATCTrCATG TGGAATGACT GG77rCAT7C AATAGACTTA ATTCAGCAGT CTGTGGGGAA GAGCAAGGTA TGATAGAATG GTTCCTCAAG TG=rCAGAT GTGAAGTGGG TT7AAATATA CTGTCCCTGT CT7CTTCAGA GT1TGGTAA AGATAAAATA GGACACTCAT TTAAAAGCAA T='~GCAAA TGACAAGCCA CTATAGACAT TAATAGAG Fr TrCA'1CCA GTATTATCAT TAATATCAGA TCCTGGAAGA AGGT-rGAGCC TrGACCTAGA GCAAAAAAAC AGAAGAA FfA GTAAAGGAAT CCTGGAGAAA GCCCCTGCTG TGTA'IMAAA GGAGAAAGGG AGATCATG FT GGGAAATTAT AATA11TAAAA GTAAACAAAA GCTAGGAAGT AAAATAAAAT AAATrATATG GCCTAGATCC CCATAAGTAA TGG Tr7AACT TCTGCCITCC TGTGT1XTGA GCCAGATTAG GGCACAGTAG AGAAAGAGGA GTCTCTGAAA ATG I=CCAA ITTCGCTGGT CAGACAGCGG ATCATCAGTG AATCAGATGA AAA7TFGTGG A'ITATGCAC TAACTGATCA GCAGGAAATT AAACAAGAAA AGCGTrGGTA GCTCTGGTGA ATCCCAAAAG AA'TrTGGCAG 'FrGCTAGCCA TGCTCCTGAA TATGTATAAA CAGTACATCA TATGACTAAG AGTTGAC77 AGGGGTrAGA 'ITFTTATGTGT TTGAACCCCA AAT[AGTTAT TTAATAG1TG GCACCCCAAA ACAAGT7ACT TAACCrCACT AAGAITCAGT =FCCTGTT7 ATAAAATGTA GATAGTGATA GTATGTA=T TATAGGATTA TrGTGAAAAA TAAATGAAAT ATCAGAMIIA 'ITAGGATAA CACCTGGCAT ATG'IMGGTA 'PTCAGTAATr AGI1TGCTGCT GTrTATTCT GCTCTCCCTT GCATCCCACT m17CTAAGrr GTAAACTAAA TAGTrGTACA CAGATTGACA GA'FAAGAAA GGCT-rGTGAT TGTGCTAGAC CTATGCCTCT CTCTCACCAG AT7CCAGGTG TATATGTGGA GGTGGGATAG GGAGTGGAGT AAGTGGGTAA ATATrAAATT GCCCAGU'GG GCACCATCCT GAATATrATC TCTAAAGAAA GAAGCAAAAC CAGGCACAGC TGATGGG'FrA ACCAGATATG ATACAGAAAA CATTrCCTrC TGCrTITGG TITAAGCCT ATAMGAAG CCTAGATCT CTCCAGCACA GTAAGCACCA GGAGTCCATG AAGAAGATGG CTCCTGCCAT GGAATCCCCT ACTCTACTGT GTGTAGC=T ACTGTTMC GGTAACITAGA GA F7CAAT-rA CCCCTCCCAG GGAGGCCCAA ATGAA'1GG GGAGCAGCTG GGGTAGGAAC C1TACTGTG GGTGGTGACT =T~AGGA CATGTGCAAA CTATTGGGCA TITCCCAGGG ACTCTGTAGT GGAGCCAAGC TAGAAAGCAG AGGCAAGTGG GCrGAGCAAC ACCTAAGGAG GAAGCCAGAC TGAAAG=TG GTTCC17GCA MTGCTCTGG CATCTrCCAG AGTGCAAAT7 TCCTACCAAG GTAATGAGGG TAGAGGAGAG AAAGAAGCTC TI7TTCCCC TGATTCTCAT TCCTGAAAAG ACGGT1'GGTC CTTAAAATTC CATGGATGTA GATCTrATCC CCACACCCAG ATTCTAGTCC TCTGGAGATA AAGAAGACTG CTGGACACTA ATGTATCCTC TCTGGAC'T TGCAGCT7CCA GATGGCGTGT TAGCAGGTGA GTCCTCTG FF CrrGrTCCcT TGGTGTATCA ACATGTCTGG GCATrGCTF CCTCTCACTA TI=CTTrCGT CCCATCA=T CTGCITCTA ATGAGCATGA ATCTGTTCCT TGGCCAGACT AC1TCCCTC TCCACCT7GC CTrGTC'=C TTITCCC TGATrCAFrG CATrCrCrCA AGTCATTCTC TCCTCTGMI TAGTCAATAA CCATGTCTGT TGCACATATA CATGTCTCAT TCTCTCTCCT AGACA=IIG GCATGATCTC GCTCAATAAT TACATTATTA TrAT-rAT7GC CATT=ATAA 'FrGAGGATGC TGAAACrCAG TGATITCTG GTGGTTACAT GGCTAAGGAA CTGGATICA ACGTAAGYrC C17GGATCTA AGTCCAGTTC TCT7CTGACT ATATCACCCT TrGT7ATCA CCATGTATCT AC=rT=GG TCTCTGTI7CA AAMfGCACT ACATCCCCT GTTCCAGGAA GCCATI'CAAG ACTGACC TTAGTGCCTC TCACTACTT CTGGAACTGA CATATGI=r TCACTCTGTA TATACTTACA ATTAAATAGT CATAAATA'Fr CAGAGCTITGG AGAAACCTrA TA'ITCATCC AGTCCAGTAA AITT7ATCCAT CCATAAT7CA CTCA FTCATF CACATAATAA ATATTTAATG TAACAATGGT TGAACATGGC AGACAGTGT7 TCTACCTCAA AAGAGATrGC AGTCCJTCATT TACAGATACT GAATrGAAAT TAACAGAAGT AGAGTGAGTC AGCTCAAATC ACATAGTGAA 'rrGG'ITT TGTIT1AAA TCTCCTGCAT ATGTGTCCTG TCTICTCCC TGTGTTGGGC GTTCCCTGGG GCACCAATAC TAATITCTCC T-fCCCCTAGA AATCAAAACA GGGTCTrATC ACCAACAGAA TAAGGACAGG TTGACCACTG A ITGTCAGAA TATTGCT7CG TJTGTAC'= TAAGCCTAGA CAG=T1CAA TGACTITIT TCrCTCTACA TGTC=flCA TA TITATC F7CTTGAAGT CCCTrCAGAAA CCTAAGGTCT CCTGAACCC TCCATGGAAT AGAATATIA AAGGAGAGAA TGTGACTCT ACATGTAATG GGAACAATT17 CFGAAGTC AG'ITCCACCA AATGGTTCCA CAATGGCAGC =TICAGAAG AGACAAATTC AAGnI7GAAT ATrGTGAATG CCAAAT-1TGA AGACAGTGGA GAATACAAAT GTCAGCACCA ACAAGTTAAT GAGAGTGAAC CTGTGTACCT GGAAGT=TC AGTGGTAAGT TCCAGGGATA TGGAAATACA GATCTCTCAT GTGAGGGATG GCTCATCTGA AGATGGGAAA AAACAGG'ITA TTCCAAGGGT TAGGACACCA GAGTGGGA17 CAAGGCCTCT CATFITAAG ACCCCTGCAT TGGCTGGGCA CAGTGGCTCA CGCCTGTAAT CCCAGCACTT TGGGAGGCTG AGGCAGGTGG ATCACGAGGT CAGGAGATCG AGACCATCCG GCTAACATGG TGAAACCCCA TCTCTGCTAA AAAATATATA TATATAAAAT TAGCCGGGCG TAGTGGTGGG CACCTGTAGT CCCAGGTACT CGGGAGGCTG AGGCAGGAGA ATGGTGTGAA CCCAGGAGGT GGAGGTTGCA GTGAGCTGAG ATCACGCCAC TGCCCTCCAG CCTGGGCTAC AGAGCAAGAC TCCGTCTCAA AAAATAAATA AATAAATAAA AAAGACCCCT GCATCTCTIT TCTTCTACCC CCTCCC'= TGATlAC1TG TATGCC~rCT 7TCAATATrC TAGTCATCTC TCAATAT7AT TCCTCCACCC TATITCCTFC TATC'IICT GCCTAGATTrC AGGTATATAT TATGTGGTCA AACAGCATGA CATATATGTG AACA'IMCAA AGAGCTGTGT ATCTGGAATA GGATCAAAAG GTTTGACMA AAGTITGCT CTGCATAATC CATATGGCAG GACCTGAATA TAGGTrGTA CTC'FrCGTrA TGAAACATAT CTGGGTACAT TTCCT7ATGT CCTCTrGTTGT TACTTAAGAA CACATAITC ATGC=GTTr CA'TrATC AGTCCTACTrG CCAACAAATA GCATAGCATG CTrAGGCACA TGTGGCTTAA 7TAGCAAATG 'rGAATAAAC AAATrAATGA IT=GAATAG TGACCAATAG GTCTCTITIA TACTCTATAT TIrCTYG AGTGAAAAAA AATGMF1CAA CCTCCATATG WO 00/09525 PCT/US99/17712 bpi-109 115 TAAATTCCAA ACACAAACTA AAGCAATGTA c3AATAGC'FrC TI[AT7CCCT GGAGTAGGFT CTAGAGAAGT CCTAAAGGAT TGGTCCTAAA TITAAUrATGC 'FrATrATGCT AGCGATA'I= CC=rCAAAA TTCTCC1TA ATGAATGCTI' TTTAATPI= ACAAAAGCAT TAACCATAGA ATGTGATrCT TGTCITCAC TGACTCA ITA GTGACAAATA IT7TTGAGT ACCTACCAAC TCCTAAGTAT TGCTACCAAC TCCTAAATAC TGTGTTGGGC A FCAGAATA GAATGTAGAA CTAGACAGGG TCCCTGACT =TGGAGCAC AGAGCAGTAT GGGAAGAGGA CATrAAATAA AGAA17ACAT AAGTAATTAA TnTAAATrAT ACATG=I1G AAGAAG=V~ TITGACAA CTATAAT7AA CACTAGAACT GGGAAGM~C TATAAGGTAA GAGAGGACAA AATAGACACT C1rCCTAAGCT AAAATTCCCA AGAAAGACTG 'ITrATICC CCTAACTAAC TAGAACTAGC AACAGAAGAT CTGAAAGGAA 'FrCTGGCT= CAAGTGTrCC ATGTATGGAC TCATCAGGGA GGTCCGAGAG GCT=GTGGC CCCAGACTGA CTITCAGGA GGGGAAAGGA TITATCAATA CACAAGACAG GCTCTAAGCA 'FrArIGTG CCC'IIAAAA ATCCAC'=A TGAGCCAAAA AGTGAGTTAA TGATAATrCA TAGTI1XTGA CACATGCTCT ATGCGTGGCT CTC'IICTC TATTCATTCT CTC]TCTICTT A'ITTATrTT AAATAAATAA TGTAATGAAT G~~TFCAGA CTGGCTGCTC CTTCAGGCC7 CTGCTGAGGT GGTGATGGAG GGCCAGCCCC TCTTCCTCAG GTGCCATGGT TGGAGGAACT GGGATGTGTA CAAGGTGATC TATATAAGG ATGGTGAAGC TCTCAAGTAC TGGTATGAGA ACCACAACAT CTCCA17ACA AATGCCACAG 77GAAGACAG TGGAACCTAC TAC'rGTACGG GCAAAGTGTG GCAGCTGGAC TATGAGTCTG AGCCCCTCAA CATTACTGTA ATAAAAGGTG AGT7GGTAAA GGAAAGGAAA AGCATCCATA GCAGGGGAAG GAAGAGAGAA CTICTGAGCC TGAGCAGTTG CAGC=rcTAG AAGGGGGGCA CCTGTGATAC ACTGGAAAGC CTACCAGACT TGCAATGAGG AGACCTGGGT GATAGTATAT ATCTCAATCT CTGTT~rCAAA GCCTTGACT7 GTTAAATGGT GATAGTAATA CCTGCTTGCA CTATGAAA'Fr 'IMATGAAGA 'FrAATGTGGT AATATI7rGTG AAATGACMF GTAAACTGTT AAGCACTACC CAAGCATAAC AGA'FGTGAT TACTATITG ATCTCAAAGT CATCTG'FrGC TCCTGGGGGA ACACTATAT TTATCAAATT GAAAAAAAGT T-rCAAAGTTG AATGAAGAAA GGATATAAAG AGCTI'GAGGA GCCCATrCCA GCYAGGAGG GCTGGGAAAG GAAACCAGCA AGTCAGTAAG CTGTGTGCCT GTGTATTGAG GGAGGAGGGA ATGGACTIGA TATGGAGAGG GTAGGGAGGT GGACTGCCTC TATGGCCTGT AAGAAAAACT GCTCTCTCCA AACTCTIAT AAGAGAGGGA GCCTGTGAAG TA'ITCAC1TT TGAAGGAGAA AG'VrAGACTI' ITC=~CACA CAC=~GTAC ATAATAATGT T[AAAAAAGC ATGAGGTCAA AATACATAAT TAAGTCCTAG CAGTTCTCTG FAACTAAFT TGAGACTGAA GTGCTATGTA =TGTCTCTA GG=TCCAGT ATCTTrCATCT GTAAAACAGA ATATITGGTC TAGATTCCAT TAGAATCATT TGATAACTTA AAAAATATAT TGATGCTCAT GTCTCATTC TTGAGATTCT GA=IAA17G GM~GGGGTG CAGCCTGGGT ATACGTA'1T FTCATAGGTC MrCACATAA TGGTAATGGG TAGCCAATAT TGAGAATCAC 'TGTCTAGGT GATCT=AAA TGA'Tr7CTGG ATGTAATATT1 CTGAGGCTCT ATAA'IMGAG ACTAATCACA AAAATCGGTA CAGTIATAA ACAGACTAAC AGAACCACAA AATAATAGAA TFGGAAGGCA ATIrAACTAG TGCAAMIICT TCA=mGCC TAACAGGCAT GTAAGAAATG ATGATTGAT7 GAGTAATAGG CAT7GATGAC CCCTGTCCTC AC'=GTCCC Cf1CCACCC CT[AATrATA TGTGAATTCT GGTCTTGTCA TITCGAATAA GGGGnI7ATC TTCCTATrG TCTCCCCTC TGGGCACGGC ACACTGGCTA CTGGAGTrAA GAGGAAATGC TTAGGACTrCC CTGTGGCTCC AGGGAGCACC AACAGAGCAA CrCAACCTAG TGTTAATCTG AGTG2TICT CTGTGC'rrCT GGATGCCACA TCACGCTAAA AATGAAGGAC AAAGC'rGGT CTICTCTrA GGGAGGATGA AACTCTGAAC CTCMTFIC AGT7CCCAAG ATGAAT[ATG TT7CTCAT7G CATCTGTGTF CCACTACAGC TCCGCGTGAG AAGTACTGGC TACAATTr TATCCCA7FG TrGGTGGTGA 'ITCTG TFGC TGTGGACACA GGATrATI7rA TCTCAACTCA GCAGCAGGTC ACA'TTTCTCT TGAAGATTAA GAGAACCAGG AAAGGCTTCA GA=TCTGAA CCCACATCCT AAGCCAAACC CCAAAAACAA CTGATATAAT TACTCAAGAA ATAnhrGCAA CATrAGTTF 'ITCCAGCAT CAGCAATTGC TACTCAAflG TCAAACACAG CTIGCAATAT ACATAGAAAC GTCTGTGCTC AAGGATI7AT AGAAATGC= CAFTAAACTG AGTGAAACTG GTTAAGTGGC ATGTAATAGT AAGTGCTCAA T'rAACATGG 'FrGAATAAAT GAGAGAATGA ATAGATTCAT 'FrATrAGCAT TTGTAAAAGA GATGTTCAAT TITCAATAAAA TAAATATAAA ACCATGTAAC AGAATG=TC TGAGTATTCA AGGCTTGCTA GTlr7G'IGT TTG'F=CTA CTAAAGGCAA GGACCATGAA GTTCTAGA'1r GGAAATGTCC TCTCTFGACT A'TrGCAAGTG CGATCTAGGA ATGAAAAGAC ATAGGAGGAT GCCAGTGAGG TGGATCAYTT 'FATGC'FCT TC=CAGC'F ACTAAATATG AACTTICAGT TCflGGCAGA ATCAGGGACA GTCTCAAGAC ATAGGACTCT CAGGATGAAG TAGAGTCCAG GATTCCTCTG TGATrGTIT GCCCCTCCCA AAMTATATC TTGAACT'rAT GT=TGTATC =~ATACAGC ACCTGAACCA AGCAT1TGG AGAAATTCCA GCTAATAATA ATAACCAAAA C=TCGGCTC TGAAAACAGT CCAGGACTGA ATAAGAT=T GGGCAAAAGA ACTAGACAGT 'FF7GGTI1AT 'FFICCCC A'IhATGTC TfTCATCATAG TCA~rGGAGG CTCATrC-ITC TGTCATGGA GTAAATGGGA 'ITAAAGTTC-3' (FRAG. NO: )(SEQ. ID NO:2501) 5'-TACTAAGAGT CTCCAGCATC CTCCACCTGT CTACCACCGA GCATGGGCCT ATA'IMGAAG CCTTAGATCT CTCCAGCACA GTAAGCACCA GGAGTCCATG AAGAAGATGG CTCCTGCCAT GGAATCCCCT ACTCTACTGT GTGTAGCCT'T ACTGT~cTITC GCTCCAGATG GCGTGTTAGC AGTCCCTCAG AAACCTAAGG TCTCCrrGAA CCCTCCATGG AATAGAATAT 'TTAAAGGAGA GAATGTGACT =TACATGTA ATGGGAACAA TrTTIGAA GTCAGTTCCA CCAAATGGFF CCACAATGGC AGCCITCAG AAGAGACAAA TTCAAGTG AATATrGTGA ATGCCAAAT7 TGAAGACAGT GGAGAATACA AATGTCAGCA CCAACAAG'Fr AATGAGAGTG AACCTGTGTA CCTGGAAGTC TTCAGTGACT GGCTGCTCCT TCAGGCCTCT GCTGAGGTGG TGATGGAGGG CCAGCCCCTC TrCCTCAGGT GCCATGGTTG GAGGAACTGG GATGTGTACA AGGTGATCTA 'FTATAAGGAT GGTGAAGCTC TCAAGTACTG GTATGAGAAC CACAACATCT CCAT7ACAAA TGCCACAGrI' GAAGACAGTG GAACCTACTA CTGTACGGGC AAAGTGTGGC AGCTGGACTA TGAGTCTGAG CCCCTCAACA FrA=TTAAT AAAAGCTCCG CGTGAGAAGT ACTGGCTACA ATTITATC CCATTGTTGG TGGTGATTCT GTTGCTGTG GACACAGGAT TA1TTATCTrC AACTCAGCAG CAGGTCACAT 7TCTCTTGAA GA'ITAAGAGA ACCAGGAAAG GC=CAGACT TCTGAACCCA CATCCTAAGC CAAACCCCAA AAACAACTGA TATAAT7ACT CAAGAAATAT TTGCAACAFF AGTITITIC CAGCATCAGC AATTGCTACT CAATTGTCAA ACACAGCT7G CAATATACAT AGAAACGTCT GTGCTCAAGG ATFMATAGAA ATG=~CA IT AAACTGAGTG AAACTGG'rrA AGTGGCATGT AATAGTAAGT GCTCAA17AA CA ITGGTTGA ATAAATGAGA GAATGAATAG ATTWATTFTAT TAGCA'IMGT AAAAGAGATG T'TCAATI1CA ATAAAATAAA TATAAAACCA TGTAACAGAA TG=~CTGAG TAAAAAAAAA AAAAAAAAAA AAAAAAAA- WO 00/09525 PCT/US99/17712 EPI-109 116 3' (FRAG. NO: ) (SEQ. ID NO:2502) 5'-TCTCAATATA ATAATATTCT TTATTCCTGG ACAGCTCGGT TAATGAAAAA ATGGACACAG AAAGTAATAG GAGAGCAAAT CTTGCTCTCC CACAGGAGCC TTCCAGTGTG CCTGCATTTG AAGTCTTGGA AATATCTCCC CAGGAAGTAT CTTCAGGCAG ACTATTGAAG TCGGCCTCAT CCCCACCACT GCATACATGG CTGACAGTT TGAAAAAAGA GCAGGAGTTC CTGGGGGTAA CACAAATTCT GACTGCTATG ATATGCCTT GTTGGAAC AGTTGTCTGC TCTGTACTTG ATAT1TCACA CATTGAGGGA GACATIr111 CATCATTTAA AGCAGGTTAT CCATTCTGGG GAGCCATATT TITFCTATT TCTGGAATGT TGTCAATTAT ATCTGAAAGG AGAAATGCAA CATATCTGGT GAGAGGAAGC CTGGGAGCAA ACACTGCCAG CAGCATAGCT GGGGGAACGG GAATTACCAT CCTGATCATC AACCTGAAGA AGAGCTrGGC CTATATCCAC ATCCACAGTT GCCAGAAATT TGAGACC AAGTGCTTTA TGGCTTCCTT TTCCACTGAA ATTGTAGTGA TGATGCTGT7 TCTCACCATT CTGGGACTTG GTAGTGCTGT GTCACTCACA ATCTGTGGAG CTGGGGAAGA ACTCAAAGGA AACAAGGTTC CAGAGGATCG TGTITATGAA GAATTAAACA TATATTCAGC TACTTACAGT GAGTTGGAAG ACCCAGGGGA AATGTCTCCT CCCATTGATT TATAAGAATC ACGTGTCCAG AACACTCTGA TTCACAGCCA AGGATCCAGA AGGCCAAGGT CTTGTrAAGG GGCTACTGGA AAAATTCTA TTCTCTCCAC AGCCTGCTGG TT-3' (FRAG. NO: )(SEQ. ID NO: 2503) 5'-AAGCTTTTCA AAGGTGCAAT TGGATAACTT CTGCCATGAG AAATGGCTGA ATTGGGACAC AAGTGGGGAC AATrCCAGAA GAAGGGCACA TCTCTCTT TTCTGCAGTT CTTTCTCACC TTCTCAACTC CTACTAAAAT GTCTCATITT CAGGTTCTGT AAATCCTGCT AGTCTCAGGC AAAATTATGC TCCAGGAGTC TCAAATTC TTATTTCATA TrAGTCTA TTTAGTAGAC TTCTCAATTT TrCTATTCAT CACAAGTAAA AGCCTGTrGA TCTTAATCAG CCAAGAAACT TATCTGTCTG GCAAATGACT TATGTATAAA GAGAATCATC AATGTCATGA GGTAACCCAT TTCAACTGCC TATTCAGAGC ATGCAGTAAG AGGAAATCCA CCAAGTCTCA ATATAATAAT ATrCTATT CCTGGACAGC TCGGTrAATG AAAAAATGGA CACAGAAAGT AATAGGAGAG CAAATCVTGC TCTCCCACAG GAGCCTTCCA GGTAGGTACA AGGTATTAT7 7ITrirCTACC CTCAGTCACT TGTGGCAGGG GAAGTCATAG TCACGGTGCT TAGGAGATGA AACTTTATTG ATTTAGGCAT GGATCCATCT AGTTrAATTA ATATATTGGG TATGAGGAAG CTACTTGCTG TACTTTCCAT GTGGTTCTCT CTCCCTGGAG AGGAACATTT TTACTCAGCT TGCAAACTGG AAATAGATT TCTCACATTA GAAGCTCATT TTCTGGGTAT GAGACAGGAG AGTTCATACT GTGTATGTAG ATCTCTGGCT TCTGGGTCTG ACATGTGCTG AGGGACACAT ATCCTTCACA CATGCTTTA TAAATACTTG ATAAAGTAAC CTGCTTCTTG ATTGGTCT ATAATCCATA AGCTGTGGGA TGCTTCTCTG AAGATGAAAA TAGTAATAGA GTCCCATCTA GCTATTCAAA GCCATrCCTT CATTGTATTC TGTGCACATG AAGTTGGGGT TTGTTACTGA CAAAATATAT TCAGATACAT TTCTATGTTA AAAGGATTGT GAGATGCATA GGTAAATGTG TTAT1TTCA GTTACTTG TCAACATAGA TGAATGAGAA AGAACTTGAA AGTAACACTG GATTAAGAAT AGGAAAAF=T GGCATGGATT TTGCTCCATT TTGTCCCATC TAATCACTTG GATAGTGTTC AGGTGTTCTT GGTCAGTTAC TTGGATGCTC TGAGCTTTAG TTTCTTGGTG ATTACAATGA AGATTTGAAT TACAGGATGG CTTTGAAAAA ATAAACAAAA CTCCCC=TTC TGTCTGTCGA GAATGTTGCA CAGGGAGTTA CAGAATGTTC TCATGACTGA ATTGCITTA AAMTTCACAG TGTGCCTGCA TTGAAGTCT TGGAAATATC TCCCCAGGAA GTATCTTCAG GCAGACTATT GAAGTCGGCC TCATCCCCAC CACTGCATAC ATGGCTGACA GT111GAAAA AAGAGCAGGA GTTCCTGGGG GTGAGTGAGC CTCCTCCAAC TGACTAGA GTAAGGGTTG GGTCTAGAAA AGAATATTGA GTrGCATCAA CTGTTTTCCC ACTTGGATTC ATGAGAGGTG TrAGGTCCTT TAAAAAACAT GGTAGATAAA GAGTTGACAC TAACTGGGTC C1Ii GGGAA GAGCCAGAAG CAITTCCTCA TAAAGACT AAATTGCTAG GACGAGAATG GCCAACAGGA GTGAAGGATf CATAACTA TCTTACTrA GATGTAAAGA ACAATTACTG ATGTTCAACA TGACTACATA CATAAAGGCG CATGGAGAAA AGTATTGGCC TTCCATGCAT TAGGTAGTGC TTGTATCAAT TCTTATAGTG GCTAGGGTAT CCTGGAAAAT CTTACGTGTG GATCATTTCT CAGGACAGTC TAGGACACTA ACGCAGTTTC TCATGTTTGG CTTCTATTAT TAAAAAATGA TACAATCTCG GGAAAATITr TTTGATTTTC ATGAAATTCA TGTGTFTC TATAGGTAAC ACAAATTCTG ACTGCTATGA TATGCCTTTG TTTTGGAACA GTTGTCTGCT CTGTACTTGA TATTCACAC ATTGAGGGAG ACAITTC ATCATTTAAA GCAGGTTATC CATrCTGGGG AGCCATATTT GTGAGTATAT ATCTATAATT GTTTCTGAAA TAACACTGAA CATAGGTTTT TCTCTCTC AGATCTAACC AGTrGTTTAT TCCCAGTATT AAGATGATAT TrATAATrCT TAATTATAAA TATATGTGAG CATATATAAC ATAGATATGC TCATTAACAA CAACAAAAGA TTCT1I1-AC AATTAACGGT GGGTTAAACA TTTAGCCCAC AGTITTATCC CATGAGAAAC CTGAATCTAA TACAAGTrAA ATGACTTGCC TAAGGGCCAC TrGACTAATA GTAATTGAAC CTAAACITTC AGAATCCAAC TCCAGGAACA TACTTCTAGC ACTATTCATC AATAAAGTTA TATGATAAAT ACATACAACT TTATCTGTCA ACTAAAAATA ACAACAGAGG CTGGGCATGG TGGCTCACAC CCGTAATCCC AGCACTTGG GAGGCTGAGG CAGGTGGATC ACCTGAGGTC AGGAGTGA GACCAGCCTG ACCAACATGG TGAAACCTCA TCTCTACTAA ATATAAAAAA TTAGCTGAGT GTGATAGTGC ATACCTGTAA TCCAGCTACT TAAGAGGCTG AGGCAGGAGG CTTGTTTGAA CCTGGAAGGC AGAGGTrGCA GTGAGCTGAG ATrGTGCCAT TGCACTCCAG CCTGGGCAAT AAGTGCGAAC TCTGTCTCAA AATAATAATA ATAATAATAG AAAATAAAGT TGTCTTCATG AAAAATGAGG AAAGAGATTG CTGGGGTGAG AAACATTAAG ATCAATGGGC ATATGGTGAC CTTCTATGCC CTAGAAACTC TITTANGGTA TCTCCTG GTATCTCIT TACNCATCGT TCTATCTGGA AAAATAGGTG GATGAGTGAG ATAATAACGG TATATACTT TTAAAGGTCT AATTGACATA TATAAATTGC AAGTATTTCA GATGTCAATT TGCTAACC=T GACACACATA GACACACATG AAAACATCAC CACATTAATA CAATGTATGT ATCCATCATT CCAAAAGCTT CCCTGTGTAT CTTTGTAACT CTTTCFTCCT CCCTCCACTC CTTGTCCTCT CGTTCCCAAG AAAACATTGA TCTGC7CCT GTGAATATAA ATTAACT7AC AITlTTAGA GCTATATA AGTATGTTCT CTTTACTGTT TGTCTTCCTT CGCTGCACAG TrA=TlTGAG AT=TCAAG TM1CTT ATATCGATAC TTCATCACA AGAATATATT TTAATTCTAG ACTATGTCAC ATTGACTG TCGTCTGCTA AATCCT7AGT GCTCAGATGA CTTGTTCAGG ACTCTCCTTG AACCTGTACC TCTGTTANAT TGAAACTTGT CTCTACTGTC 7ITITAITTC AAACACAGCT TATTAGGTGT CTCTCAACCC ATCAAACNCA CAATCTGAGT CTAGGAGA TTGCTTTGAA TGTGCTAT TGACTTATAT NTATATNAAA TNTGTAAATG TTTGGTAAAA ATATCATCAT GTACNCTTC ATAATTACGC TATNTNCACA TGATATATGT CAGACTCTGG AAATATGCAT GCCACAGACA CGTGTTTCTT GCCTAAAGGG GCTGATGGAA GACNCACATA CNAATAGACG ATTGCAGTAG AATGAGAGTG GTGGTCTAAN CAGTACATGT CCTGATGTTG CTCGGACAGT TACTACNCCA AGAGTACCCC CTGCATTGTC AGGGTTAGCA TCTCCTGGAA GCCTCATGTA AATGAAGAAT TTCATGCTCC ATCCAGGACC TAATGAATAA GAATCTGCAT TTTAGCAAGA CCCTCATATG ATTCATATAC ACLI1T1T11 TITITfTITA GATGGAGTCT CACTCTTGTC GCCCAGGCTG GAGTGCAATG GCATGATCTT GGCTCACTGC AACCTCTGCC TCCCGGGTTC AAGTGATTCT CCTGTCTCAG CCTCCCTAGT AGCTGGGACT ACAGGTGCAT GCCACAGTGG CTGGCTAATT TTTGTATTT TAGTAGAGAC AGGGTTTCAC CATTTTGGTC AGGCTGGTCT TGAACTCATG ACCTCCGGTG ATTCCCCCGC CTCGGCTTCC CAAAGTGCTG GGATTACAGA CATGAGCCAC CACACCCGCC TTATTCGTAT ACNCATTTAA TTCTGAGAAG CACTCTATAG AAAATAAGAA TAAGAAAATA TTGGGCTCAC AGGTGACATT AATAAGTAAC TTTATCGAGT ACCCCAAATT TTACCTATGT TTGGAAGATG GGGTrAAAAG GACACATTGA AAACAAGAAC TCATTGTGGC ITITTCC TCCTTGA WO 00/09525 PCT/US99/17712 EPI-109 117 ACAG=IrCT ATI1CTGGAA TGTTrGTCAAT TATATCTGAA AGGAGAAATG CAACATATCT GGTGAGT-rGC CCfG=rCTcIT =T1GTCCAT CCT-rGAAAAG ATAAGAAGAA CAGAGTI=A AGAGTCTrAA GGGAAACACA TCTTGTCTC CTATATTACT TGTGAATGTG GATATATGAT M~G=TCAA TCTATITGT GTCCTAAGGC FTTGCAAC AGAAGTTGGA TATATCATrA GAAACATAAA TTGTACCA'Fr TAACATACAT GAAGTI1ATG TTrAC=TGA CG~FFC1CTA AAAAGTGTCC TACACCGGCA 'TrGTCCTFGT AGGCATAFI'C ACATGATCAA ATAAAATAAT TAGT1TCAA 7FAAGGAGAA TA'IMGAGGA AAGACCGTAC GTG TrCATGT GGTI'CCTGAA GGCAGTCCAG TGAGAAAGTA ATATATGCTT CATTAAACAA TGCGGACAT7 TTCAGGG1T7 CCCTV1TAA CCAAAAMrG GAAGCAATGT GGAATACT GGATGCATCC AGCCCTGAAA TGAAGATAGG 'IMATrGAAT GTGCCAGCAA GTGCAGGCCC AGGTCTGAGT G TrCATT ATI'ATCAGGT GAGAGGAAGC CTGGGAGCAA ACACTGCCAG CAGCATAGCT GGGGGAACGG GAATTACCAT CCTGATCATC AACCTGAAGA AGAGCIGGC CTATATCCAC ATCCACAGTr GCCAGAAATTr =ITGAGACC AAGTGC'IA TGGCTrCMT TCCACTGTA TGTATTIT =IGTGTGGG AAGACTAAGA T-rCTGGGTCC TAATGTAAGT AAGAAGCCCT CIrCTCCTGT TCCATGAACA CCATCCT1T CTGTAA=TC TAT7ACACAG TATAGTGGTT CTGTAAGT-7C ACACAGCCCA GGGAGATGCT GGCTGCCCAC TCCCCTCAAC CCAGGCAAAT TCCTCGGGGT TAAAGTrATC TACTGCAAGT GACGATCTCT GGGTTCT GTGCCTGTGT TrGTGTGTGT GTGTGTGTGT GTGTGTGTGT GTATGTGTCA C=lAAAAGG ACTGGTCAGA TGGTAGGGAG ATGAAAACAG GAGATGCTAT AAGAAAATAA ACTITGGGG CGAATACCAA TGTGACTCTI MIIG1TGTC A'ITGTTGCT GTfCAATAGG AAATrGTAGT GATGATGCTG 'ITCTCACCA TTCTGGGACT TGGTAGTGCT GTGTCACTCA CAATCTGTGG AGCTGGGGAA GAACTCAAAG GAAACAAGGT AGATAGAAGC CCGATATAAA ATCT7GAATG ACAGGTTAAC GAATTGGAGC 'I=AlrCCTT AAAATATGGC CTGGGTITC TGAAACA=~ =~CCAGAAA ATAG'ITCTC CAAG=r~AT TA=1'GG TF TACAAATCTC ACATI17AAAT CACATITAT ACCATAAGTA GCACACA=I CATAATATTC CTCTGAATGA GGGT-rGGGAT AATAGGACTG ATATGT17AGA AATGCCTTAA AGTGTGTGGA GCATGAGAGA TGGATGTACA GAAGGCTrGT GAGGAAACCA CCCAGGTATC TGGCCTrGTT TrCTGCCCCA GAACTAGCCG CCTKFTTCCTG TITCTGTTI ATTCC=rGT Tr=~GACTr 'FrCCI=CCA A=TGCTCTA AAACCTCAGT 'TrC=CCT 'TCTGATTCA TGACTACCAA ATGFITCAC FGCCTCACC CGTCCATrAC AC=T1GATA AGAACCACCA GACCTTGTGC TCATGTACT7I GCCCATGTCT GATGGAAGAA ACATACTCTC TCCATCTGTC CACT1TCCTG AGGCATTCAA GTCTAGCCAC CTITAAAAT CACTCTCCTC CAGGCTGGGC ACGGTGTCAC GCCTGTAATC TCAGCAC'T GTGAGGCTGA GGAGGGCGGA TCACTTGAAG TCAGGAGTTC AAAACCAGCC TGGCCAAATG GCAAAACCAA ATCTTC'TCA ATTATAACCA AATCTrAAAC CAAATCTCTA CTAAAAAATA CAACAAAACA AAACAACAAC AACAAAAACA GAAAAGGAAA CATTAGCCCA GCGTGGTGGC AGGTACCTGA GGITCCAGAT ACTI7GGGAGG CTGAAGCAGG AGAATCGCTT GAGCCCAAGA GATGGAGGT-F GCAGTGAGCC GAGATCATGC CACTGCACCA CAGCCAGGGT GACAGAGCCA TACTrCCCAG CACAT7GGGA GGCCAAAGCT GAAGAATAAT TTGAGGTGAG GAI=GGAGA CCAGCCTGGC CAACATGGTG AAACTCCGTC TGTACTAAAA ATATAAAACT TAGTGGGGCA TGGGGGCACA CACCTGTAAT TT1CAGCTACT TAGGAGGCTG AGGCAGGAGA ATTGCTTGAA CCCGGGAGGC GGAAGTrGCA GTGAGCCAAG ATCGTGGCCA CTGCACTCCA GCCTGGGTGA CATAG1TGAGA TCrGTCTCA AAAAAAATAA AAGAAA'ITA AAAAATCACT CTCTTCCAAA GATAGATAAA TAAGACAGCA GATATACTAA GGAATAACCT CACCAACTrG TCAT7GACTG ACATGATIC Tr=GGCCCA CT17GGCCAGC TAGTCTGG~r TGG=FTCTG GAAATGAAAG AAATAATCAG AGT7TAATGA CAGAGAGCGT GAGACCCAGA AAGACAAAAG TAGATGAGGT AAGTCTC'ITG AGCGAGACTI CTAGGGATGG GAAAI=GTG GTGATTGATA TGAAATGATr 'I=CCCrTAT CAGGTTCCAG AGGATCGTGT 'ITATGAAGAA T-rAAACATAT ATrCAGCTAC TrACAGTGAG TTGGAAGACC CAGGGGAAAT GTCTCCTCCC A~rGATR'AT AAGAATCACG TGTCCAGAAC ACTCTGATTC ACAGCCAAGG ATCCAGAAGG CCAAGGTIT GTTAAGGGGC TACTGGAAAA A'I=CTATrC TCrCCACAGC CTGCTGGTI TACATrAGAT TrAT7CGCCT GATAAGAATA =FTG=ICT GCTGCTCTG TCCACCI17AA TATGCTC=1 CTA'17GTAG ATATGATAGA CTCCTATIT7 TCYrG=ITA TATrATGACC ACACACATCT CTGCTGGAAA GTCAACATGT AGTAAGCAAG ATrAACTGT TT'GATrATAA CTGTGCAAAT ACAGAAAAAA AGAAGGCTGG CTGAAAGTTG AGTTAAAC1T TGACAG'IMG ATAATAnITG GTTCTTAGGG 'FTITITlr =ITAGCATT CTTAATAGTr ACAGT7GGGC ATGATrGTA CCATCCACCC ATACCCACAC AGTCACAGTC ACACACACAT ATGTATrACT TACACTATAT ATAACTI'CCT ATGCAAATAT T17ACCACCA GTCAATAATA CATTTIGCC AAGACATGAA GTITATAAA GATCTGTATA ATI'GCCTGAA TCACCAGCAC ATTCACTGAC ATGATATT1AT TTGCAGA'FrG ACAAGTAGGA AGTGGGGAAC 1TFATTAAG 77ACTCG'FrG TCTGGGGAGG TAAATAGGTF AAAAACAGGG AAA'ITATAAG TGCAGAGATr AACAITTCAC AAATGTFIAG TGAAACATr GTGAAAAAAG AAGACTAAAT TAAGACCTGA GCTGAAATAA AGTGACGTGG AAATGGAAAT AATGGTITATA TCTAAAACAT GTAGAAAAAG AGTAACTGGT AGATI=GTr AACAAA'FrAA AGAATAAAGT TAGACAAGCA ACTGGTrGAC TAATACAT~rA AGCG TTGAG TCTAAGATGA AAGGAGAACA CTGG17ATGT TGATAGAATG ATAAAAAGGG TCGGGCGCGG AGGCTCACGC CTGTAATCCC AGCCC'TGG GAGGCCGAGG TGGGCAGATC ACGAAGTCAG TAG7I1rGAGA CCAGCCTGGC CAACATAGTG AAACCCCGTC TCTACTAAAA ATACAAAAAA AAAATTAGCT GGGTGTGGTG GCAGTCACCT GTAGTCCCAG CTACTrGGGA GGATGAGGCA GGAGAATCGC UTGAACCTGG GAGGCGGAGG TTGCAGTGAG CCGAGATCGC ACCAGTGCAC TCCAGCCTTG GTGACAATGG GAGACTCCAT C7CAAAAAAA AAAAAAAAAA AAAAAAGATA AAAAGTCAGA AATCTGAAAA GTGGAGGAAG AGTACAAATA GACCTAAAT[ AAGTCTCATT =I~GGC1T GATITGGGG AGACAAAGGG AAATGCAGCC ATAGAGGGCC TGATGACATC CAATACATGA GTrCTGGTAA AGATAAAAT7 TGATACACGG 7TGGTGTCA 'FrATAAGAGA AATCAT7AT7 AAATGAAGCA AGTTAACACT CTAAGAGAAT TATITGAGA TAGAAGTGAA GCTAAGCTAA ACTTCACATG CCTATAATTG GAGGGAAAAA CTAAGGATAA AATCTAGCCT AGAAGATACA ATAATrAGTC ATAAACATGC ATTGTGAAAC TGTAGAGAGC AGGTAGCCCA AAATAGAGAA AGATI'AGATA AAGAGAAAAT AAGTATCCAT CAGAGACAGT ATCTCTAGGC TlGGGCAAGA GAAAAGTCCA CAGTGATAAG CAACTCCACC TAAGGCATGA ATATGCGGCA GAGAAAACAG CAATAGTGAA TGAATGCAAA AGGTGCTGAG CAAAT'rCCAC ACATGAGTAT TGTGCATGAG TAAATGAATA AAACA1TrGC AAAGACC'= AGAGAAAGAG AATGGGAGCA TATGTGCGAA ATAAGATAGT TGA'FrATGAA TAGAAGGTAG TGAAGAAAAG CAAGCTAAGA AAAAATrCTG ITATAAAAG AAGGAAAAdA TAGT[fATGT TITAGCCTA AGTATAAGAG TCCTACAGAT GGACTGAAAA AAATCAGTCT GAGAGTA'IA GTCACAATTA ATGAAATAAT TACATITAT GTATTGAGGA TGCCAAGAT~r AAAAGGTGAC AGGTAGATGT TAA'TTrCCCT AGATTGTGAA AGTGATCACG ACAATCACAC AACAAATAAT TAAGTGACTT GGTATGCI= A=TAATTGT AGGGCCTGAG GTITCCAT7 CTCATTIC TAAAATACAA 'IrGnTrCT CCAAATJTGA CAGCAGAATA AAAACCCTAC CC'TTCACTG TGTATCATGC TAAGCTGCAT CTCTACTCTT GATCATCTGT AGGTATTAAT CACATCACT CCATGGCATG GATGflCACA TACAGACTCT TAACCCTGGT TlACCAGGAC CTCTAGGAGT GGATCCAATC TATATOITA CAGTTGTATA GTATATGATA TCTCTITAT TTCACTCAAT 'VrATA=F~C ATCAITrGACT ACATAITCT TATACACAAC ACACAA1TTrA TGAATITIT CTCAAGATCA TrCTGAGAGT TGCCCCACCC TACCTGCCTT TTATAGTACG CCCACCTCAG GCAGACACAG AGCACAATGC TGGGGTI'CTC 7FCACACTAT CACTGCCCCA AATTGTC'TI CTAAA=TCA ACTI'CAATGT CATCTCTCC ATGAAGACCA WO 00/09525 PCTIUS99/17712 EPI-109 118 CTGAATGAAC ACCTTCAT CCAGCCTTAA TTTCTTGCTC CATAACTACT CTATCCCACG ATGCAGTATT GTATCATTAA TTATT1AGTGT GCTGTGACC TCCTTATGTA TTCTCAATTA CCTGTATTG TGCAATAAAT TGGAATAATG TAACTTGATT TCTrATCTGT GTGTGTrG GCATGCAAGA TTTAGGTACT TATCAAGATA ATGGGGAATT AAGGCATCAA TAAAATGATG CCAAAGACCA AGAGCAGT=r CTGAAGTCCT CCTTTTCATC AGCTCTTTAT CAAACAGAAC ACTCTATAAA CAACCCATAG CCAGAAAACA GGATGTAGGA ACAATCACCA GCACACTCTA TAAACAACCC ATAGCCAGAA AACAGAATGT AAGGACAATC ACCAGCCATC TTTTGTCAAT AATTGATGGA ATAGAGTTGA AAGGAACTGG AGCATGAGTC ATATTTGACC AGTCAGTCCT CACTCTTATr TACTTGCTAT GTAAACTTGA GAAAGCrT= TTCTCTTGT GAACCTCAGG =TTTACATCT GAAAATGAGA AATTTGGAAC AAAAGATTCC TAACTGGTCT TTCTGTTCCC ATATTCTGTG AT1TTTCAAT ATTTAGGATr TTTGGTAATC ACAATTACTT AGTGTGGT TGAGATAGCA ACACGAATCA GAACTATTTG GTGGACATAT TTCAAAGGA GTAGCTCTCC ACTGGGTA AAGAAGTGAT GCNGGTCGTG GTGGCTCACG CCTGTAATCC CAGCACTTTA GGGAGGCCAA GGCGGGTGGA TCACGAGGTC AGGAGATCGA GACCATCCTG GCTAACACGG TGAAACCCCG TCTCTACTAA AAAATACAAA AAATTAGCCA GGCGTGGTGG CGGGCGCCTG TAGTCCCACG TACTCGGGAG GCTGAGGCAG GAGAATGGCA TGAACCAGGG AGGCGGAGCT TGCCGTGAGC CGAGATAGCG CCACTGCAGT CCCTCCTGGG CAAAAGAGCA AGACTGCGTC TCAAAAAAAA AAAAAAAAAA AAAAAAAGAA GTGTGTGGAG TAGCAGGACA CCTGCAACAA TAATATIri CTAAATCCCT CTGAAAAATG CTAATCAAAG GG'ITIT ITC CTAAAAATTG TCTTAGAAAT AAAATTTCCC CTITGGGAGA CCGAGGCTGG CAGATCACGA GGTCAGGAGA TAGAGACCAC GGTGAAACCC CGTCTCTACT AAAAATACTA AAAATTAGCC GGGGNGTGGT GGTGGGTACA CCTGTAGTCC CAGCTACG GAGGCTGAGG CTGGAGAATC ACGTGAAC-3' (FRAG. NO:_)(SEQ. ID NO:2504) Human Histidine Decarboxvlase Nucleic Acid and Antisense Oligonucleotide Fragments 5'-TCT CCC TTG GGC TCT GGC TCC TrC TC TCT CTC TCC CTC TCT CTC TGT CGC CTC CGC CCT GGC TGC TGG GGT GGT GGT GC T TGT TCr TCC TTG CTG CC GCC CCG CTG CT GTC T TC CTC G CTC TGT CCC TCT CTC TCT GTB CTC CTC BGG CTC CBT CBT CTC CCT TGG GC-3' (FRAG. NO:1700) (SEQ. ID NO:1711) 5'-GGC TCT GGC (FRAG. NO:1701) (SEQ. ID NO: 1712) 5'-CCC TTG G (FRAG. NO:1702) (SEQ. ID NO: 1713) 5'- TT TGT TCr TCC (FRAG. NO:1703) (SEQ. ID NO: 1714) 5'- TCT CCC TTG GGC TCT GGC TCC TTC TC-3' (FRAG. NO:1024) (SEQ. ID NO: 1034) 5'- TCT CTC TCC CTC TCT CTC TGT -3' (FRAG. NO:1025) (SEQ. ID NO:1035) 5'- CGC CTC CGC CCT GGC TGC TGG GGT GGT GGT GC-3' (FRAG. NO:1026) (SEQ. ID NO:1036) 5'- TIT TGT TCT TCC TTG CTG CC-3' (FRAG. NO:1027) (SEQ. ID NO:1037) 5'- GCC CCG CTG CTT GTC T TC CTC G-3' (FRAG. NO:1028) (SEQ. ID NO:1038) 5'-CTC TGT CCC TCT CTC TCT GTB CTC CTC BGG CTC CBT CBT CrC CCT TGG GC (FRAG. NO:1029) (SEQ. ID NO:1039) Human Beta Tryptase Nucleic Acid and Antisense Oligonucleotide Fragments 5'-CTT GCT CCT GGG GGC CTC CTG GTC CCT CCG GGT G1T CCC GGC GGG CCT GGC CTG GGG CBG GGG CCG CGT BGG CGC GGC TCG CCB GGB CGG GCB GCG CCB GCB GCB GCB GBT TCB GCB TCC TGG-3' (FRAG. NO:1704) (SEQ. ID NO: 1715) 5'- GCT CCT GGG GGC CT-3' (FRAG. NO:1705) (SEQ. ID NO: 1716) 5'-CGT BGG CGC-3' (FRAG. NO:1706) (SEQ. ID NO: 1717) 5'-T GGC CTG GGG-3' (FRAG. NO:1707) (SEQ. ID NO: 1718) 5'-CTT GCT CCT GGG GGC CTC CTG-3' (FRAG. NO:1030) (SEQ. ID NO:1040) 5'-GTC CCT CCG GGT GTT CCC GGC-3' (FRAG. NO:1031) (SEQ. ID NO:1041) 5'-GGG CCT GGC CTG GGG CBG GGG CCG CGT BGG CGC GGC TCG CCB GGB CGG GCB GCG CCB GCB GCB GCB GBT TCB GCB TCC TGG-3' (FRAG. NO:1032) (SEQ. ID NO:1042) Human Trvptase-I Nucleic Acid and Antisense Oligonucleotide Fragments 5'-CTT GCT CCT GGG GGC CTC CTG GTC CCT CTG GCT G TT CCC GGC CCT GGB CTG GGG CBG GGG CCG CGT BGG CGC GGC TCG CCB GGB CGG GCB GCG CCB GCB GCB GCB GGC TCB GCB TCC TGG CCB CGG BBT TCC-3' (FRAG. NO: 1708) (SEQ. ID NO:1719) 5'-CT CCT GGG GGC CTC CG-3' (FRAG. NO:1709) (SEQ. ID NO:1720) 5'-B TCC TGG CCB CGG BBT TCC -3' (FRAG. NO:1710) (SEQ. ID NO:1721) 5'-GTC CCT C-3' (FRAG. NO:1711) (SEQ. ID NO:1722) 5'-CTT GCT CCT GGG GGC CTC CTG-3' (FRAG. NO:1033) (SEQ. ID NO:1043) 5'-GTC CCT CTG GCT G TT CCC GGC-3' (FRAG. NO:1034) (SEQ. ID NO:1044) 5'-CCT GGB CTG GGG CBG GGG CCG CGT BGG CGC GGC TCG CCB GGB CGG GCB GCG CCB GCB GCB GCB GGC TCB GCB TCC TGG CCB CGG BBT TCC -3' (FRAG. NO:1035) (SEQ. ID NO:1045) Human Prostaglandin D Svnthase Nucleic Acid and Antisense Oligonucleotide Fragments 5'-GGT GTG CGG GGC CrG GTG CC CCT GGG CCT CGG GTG CTG CCT GT GCG CTG CCT TCT TCT CCT GG GTC CTC GCC GGG GCC CTT GCT GCC CTG GCT GT GCC CTG GGG GTC TGG GTT CGG CTG T CCC CBG CBG GBC CBG TCC CBT CCB CBG CGT GTG BTG BGT BGC CBT TCT CCT GCB GCC GBG-3' (FRAG. NO:1712) (SEQ. ID NO:1723) 5'-T TCT CCTGCB GCC GBG -3' (FRAG. NO:1713) (SEQ. ID NO:1724) 5'-CTT GCT GCC CTG GCT GT-3' (FRAG. NO:1714) (SEQ. ID NO:1725) 5'- TCT TCT CCT GG-3' (FRAG. NO:1715) (SEQ. ID NO:1726) 5'-GGT GTG CGG GGC CTG GTG CC-3' (FRAG. NO:1036) (SEQ. ID NO:1046) 5'-CCT GGG CCT CGG GTG CTG CCT GT-3' (FRAG. NO:1037) (SEQ. ID NO:1047) 5'-GCG CTG CCT TCT TCT CCT GG-3' (FRAG. NO:1038) (SEQ. ID NO:1048) 5'-GTC CTC GCC GGG GCC CTT GCT GCC CTG GCT GT-3' (FRAG. NO:1039) (SEQ. ID NO:1049) 5'-GCC CTG GGG GTC TGG GTT CGG CTG T-3' (FRAG. NO:1040) (SEQ. ID NO:1050) 5'-CCC CBG CBG GBC CBG TCC CBT CCB CBG CGT GTG BTG BGT BGC CBT TCT CCT GCB GCC GBG -3' WO 00/09525 PCTIUS99/17712 EPI-109 119 (FRAG. NO:1041) (SEQ. ID NO:1051) Human Cvclooxygenase-2 Nucleic Acid and Antisense Oligonucleotide Fragments 5'-GGG CGC GGG CGB GCB TCG C TTT GGG CTT TTC TCC TTT GGT T TGB GCG CCB GGB CCG CGC BCB GCB GCB GGG CGC GGG CGB GCB TCG CBG CGG CGG GCB GGG-3' (FRAG. NO: 1716) (SEQ. ID NO:1727) 5'-G GCB GGG -3' (FRAG. NO: 1717) (SEQ. ID NO: 1728) 5'-TCC TIT! GGT T-3' (FRAG. NO:1718) (SEQ. ID NO:1729) 5'- GGG CGC GGG CGB GCB TCG C-3' (FRAG. NO:1042) (SEQ. ID NO:1052) 5'- TTT GGG CTT TTC TCC TIT GGT T-3' (FRAG. NO:1043) (SEQ. ID NO:1053) 5'-TGB GCG CCB GGB CCG CGC BCB GCB GCB GGG CGC GGG CGB GCB TCG CBG CGG CGG GCB GGG -3' (FRAG. NO:1044) (SEQ. ID NO:1054) Human Eosinophil Cationic Protein Nucleic Acid and Antisense Oligonucleotide Fragments 5'-CCT CCT TCC TGG TCT GTC TGC CBG BCB BBT 'TG GGB BGT GBB CBG TIT TGG BBC CBT GTT TCC CBG TCT CTG BGC TGT GGC-3' (FRAG. NO: 1719) (SEQ. ID NO: 1730) 5'-TTC TCC TTT GGT T-3' (FRAG. NO:1720) (SEQ. ID NO: 1731) 5'-T TTC TCC TTT GGT T-3' (FRAG. NO:1721) (SEQ. ID NO:1732) 5'- GGG CGC GGG CGB GCB TCG C-3' (FRAG. NO:1042) (SEQ. ID NO:1052) 5'- T GGG CTT TTC TCC TIT GGT T-3' (FRAG. NO:1043) (SEQ. ID NO:1053) 5'-TGB GCG CCB GGB CCG CGC BCB GCB GCB GGG CGC GGG CGB GCB TCG CBG CGG CGG GCB GGG -3' (FRAG. NO:1044) (SEQ. ID NO:1054) Human Eosinophil Derived Neurotoxin Nucleic Acid and Antisense Oligonucleotide Fragments 5'-GCC CTG CTG CTC TTT aG CT TCC CTT' GGT GGG TTG GGC C GCT GGT TGT TCT GGG GTT C TTG CTG CCC CTr CTG TCC C TGT TTG CTG GTG TCT GCG C 5'- CCC CBB CBG BBG BBG CBG BCB BBT TTG GGB BGT GBB CBG TTT TGG BBC CBT GTT TCC TGT-3' (FRAG. NO: 1722) (SEQ. ID NO: 1733) 5'-TTC CTG T-3' (FRAG. NO:1723) (SEQ. ID NO: 1734) 5'-CTC TT CTG CT-3' (FRAG. NO: 1724) (SEQ. ID NO:1735) 5'-CCC CTT CTG TCC C-3' (FRAG. NO:1725) (SEQ. ID NO: 1736) 5'- GCC CTG CTG CTC IT! CTG C-3' (FRAG. NO:1047) (SEQ. ID NO:1057) 5'- TCC CTT GGT GGG TFTG GGC C-3' (FRAG. NO: 1048) (SEQ. ID NO:1058) 5'- GCT GGT TGT TCa GGG GTT C-3' (FRAG. NO:1049) (SEQ. ID NO:1059) 5'- TTG CTG CCC CTT CTG TCC C-3' (FRAG. NO:1050) (SEQ. ID NO:1060) 5'- TGT TTG CTG GTG TCT GCG C -3' (FRAG. NO:1051) (SEQ. ID NO:1061) 5'- CCC CBB CBG BBG BBG CBG BCB BBT TTG GGB BGT GBB CBG T! TGG BBC CBT GTT TCC TGT-3' (FRAG. NO:1052) (SEQ. ID NO:1062) Human Eosinophil Peroxidase Nucleic Acid and Antisense Oligonucleotide Fragments 5'-GCG CTC GGC CTG GTC CCG G GGG TCT CCT C GTT GTT GC TTG CGC CTC CTG CTG GGG GT CC CTC TGT TCT TGT TTT GGG GGC GGG CCC GGC CGT TGT CTT G GTT TGG GGG TFT CCG TTG GGG TTC TCC TGG CCC GGG CCT TGC CC GGC CGT GGT CCC GGC TTC GTTCCT GTC TCC GTC TCG GCT CTT CTG GGG CCT TGC GCT GTC TTT GGT G 5'-GCB CCG TCC BGT GBT GGT GCG GTB CTT GTC GCT GCB GCG CTC GGC CTG GTC CCG GBG BGC CACCGCTCCT GTCAGCCAAC AAATATCCAT TGAGCGACAC CTGTGTCCCA GGTGCTGCTC TGGGCCCTGG GAGAAGTGCA TCAGTGGGCT TGGTAGTAGA GGGTAGGGAT GGAGTGAAGG GTAGGCAGGA AGAATGTCCC CAGGCTGGTA GGAGGTGGGG TG66GGGTTT CAGTCTCAAA ACTCCCATGA AAACCAGAGA GAAGTITCAG AACTCCACCC AAGAGGCTGG GTTCTAGGG CCCAGAGCTG CCCTCCCCCA CCCTAGAATG GGCTATAAAA GTCCCTTCCC AGCTACGTCC AGAGAAGAGC TGGAGGAAGT GAGAGGTCGG CTGGGGGTCC TCAAAGTGAG AGGGGAGCAG AGGATCCCC CGTGCAGGCT GTGGATGTCA CTCACTTCCC AGCTGGTGAA GCCTCGCTGC AGAGATGCAT CTGCTCCCAG CCCTGGCAGG GGTCCTGGCC ACACTCGTCC TCGCCCAGCC CTGTGAGGGC ACTGACCCAG GTAATAGTCC CCTAGACAGG CAAGGAGGAG GGAGGGGAAA TGGAAGGGGA AGCACTTGGG TCTGGAGGG GGTCTTGTGG CTTGCTGAAC CCTGAGTCCC CATCTCTG AACAGCCTCC CCTGGGGCAG TGGAGACCTC GGTCCTGCGA GACTGCATAG CAGAGGCCAA GTTGCTGGTG GATGCTGCCT ACAATTGGAC CCAGAAGAGG TGGACTT!GGG TCTGGGGGCT GCATGGGCCT GGGAGGATCA GT TAATACCTTG TGGGGTCAGG GAGCCCATGT CCCGTGCTGA TGTTATTTCC CCACCAGGTC CGGGCTGTCT CCAACCAGAT TGTGCGCTTC CCCAATGAGA GACTGACCTC CGACCGTGGC CGAGCCCTCA TGTTCATGCA GTGGGGCCAG TTCATTGACC ATGACCTGGA CTCTCCCCG GAGTCCCCGG CCAGAGTGGC CTTCACTGCA GGCGTTGACT GTGAGAGGAC CTGCGCCCAG CTGCCCCCCT GCTTTCCCAT CAAGGTACCT ACCCTCAGCC AATCTCCCAT GCCCTTGTGT GGCCTCCCCC AAAGGCAAGG TGCTGGGGGT GGGGATCTGG AAGACTGGAG CACCATCCTT AAGGAGCTGC CTGTGGAGCT AGGGTATGAG ACAGAGACAC AAG CACTGTCTCC TCTTCCATCT CAGATCCCAC CCAATGACCC CCGCATCAAG AACCAGCGTG ACTGCATCCC TTTCTTCCGC TCGGCACCCT CATGCCCCCA AAACAAGAAC AGAGTCCGCA ACCAGATCAA CGCGCTCACC TCCTTTGTGG ACGCCAGCAT GGTGTATGGC AGTGAGGTCT CCCTCTCGCT GCGGCTCCGC AACCGGACCA ACTACCTGGG GCTGCTGGCC ATCAACCAGC GCTTTCAAGA CAACGGCCGG GCCCTGCTGC CCITTCGACAA CCTGCACGAT GACCCCTGTC TCCTCACCAA CCGCTCGGCG CGCATCCCCT GCTTCCTGGC AGGTCAGACA GGGAGGAAGG TGGTGTCTTC CCAGGAAACA GCCATCCCTG GGGTCCCAAC TGGGAAGCAA TGGTGGGATG TGGTGAAGGT ACATGGTTTG GGACCTCAGT ATTAGGCACA CCATAAGCAT GGATCTGTGC AC TGAAGAGATG GAGGTCCAGT GAGGGCCAGG AGTTTGGCCC ACCCCGTCTC TCCCATCCCC AGCCCTGGGT CTACCCTGGT AGAAAGACAT TTCTCTGGGA AAGGCTGCAG TAAATCTGAG CTTGGGGTTT TCAAGGTGAC ACCCGATCAA CGGAAACCCC CAAACTGGCA GCCATGCACA CCCTCTAT GCGAGAGCAC AACCGGCTGG CCACCGAGCT GAGACGCCTG AATCCCCGGT GGAATGGAGA CAAACGTAC AATGAGGCTC GGAAGATCAT GGGGGCCATG GTCCAGGTAA GGAGCTCTGC ATCCCAGCAT CCCCC CTTTGTATCT CCACCCACCA ATAGTAAATTr AATGTTGTCA CATTTGACGT GATGACAATA AAGAATATGT CTGAGCCACC CTTTGAAAAG GCAAGGGTAT GGGTGAGTAG CCTCTGGGGA ATGTTCCTCC TGTCTCCCT TCCAGATCAT CACCTACCGA GACTTTCTGC CCCTGGTCT GGGCAAGGCC CGGGCCAGGA GAACCCTGGG GCACTACAGG GGGTACTGCT CCAATGTGGA CCCACGGGTG GCCAATGTCT TCACCCTGGC WO 00/09525 PCT/US99/1 7712 EPI-1 09 120 CTrCCGCIT GGCCACACAA TGCTCCAGCC CTTCATGTTC CGCTTGGACA GTCAGTACCG GGCCTCCGCA CCCAACTCGC ATGTCCCACT TAGCTCTrGCC T-rCVGCCA GCTGGCGGAT CGTGTATGAA GGTGACCAGG =1rCCAGGG GGCAAATGGG GGTGAGGGTG GGGAGCATGC CCTCCCCTAG GTGG TCCAGCTGCT TCATGTCTCT CCAGAACTCT GIT~CCTGAC AAACGTTACT AACATACCCG ACTGGCT-rGT CCAGCTCTGG GCTAGCTTGG CATCATGTGA TAACCCAAGT AGCITrCCCAG AGGCTGGTCC AATCTGTGCT GCTCACAT-fC CCTGCCACCA GGGGGCATCG ACCCCATCCT CCGGGGCCTC ATGGCCACCC CTGCCAAGCT GAACCGTCAG GATGCCATGT TAGTGGATGA GCTCCGGGAC CGG1CTGM~C GGCAAGTGAG GAGGATrGGG CTGGACCTGG CAGCTCTCAA CATGCAACGA AGCCGGGACC ACGGCCTTCC AGGTGAGGGG GCTGTCCACC TC=CTCCCA GC1TGCTCG GGCCAGGCTG CTCAAGGGGT TCTGGGAAGA CCCTGGTACC CGACTGCCTG GTAGGTTCTG GTGGCAGAAA CGAGGTGTI TCACCAAAAG ACAGCGCAAG GCCCTrGAGCA GAATJCC17 GTCTCGAAT , ATATGTGACA ATACCGGTAT CACCACGGT'r TCAAGGGACA TC17CAGAGC CAACATCTAC CCTCGGGGCT TrGTGAACTG CAGCCGTATC CCCAGGrrGA ACCTATCAGC CTGGCGAGGG ACATGAGGCT TCTGCAGGTA AGGGGAGGCC ACCTCCAGCA CCCTGGGCTG G'ITAAGCCTC ACATCCTTCC CTGGATGGAT GGCTGAGTCC TCTTAGGTCT CTAAGCAGAG AAAACAGAAC 7rGTCACTAG GTAcTCC CAAGTGGCTT CCCAATGTGC TAG'I=CT3G GCTGACAGTC AATrCCAGGC CCTAGGACT7 TGGGGGGAAA TrAGGAGCAT CCAACTA GAAT7CCGTG GCCAGGACCC CTGCCAGGGC ACTGACCCAG CCTCCCCTGG GGCAGTGGAG ACCTCGGTCC TGCGAGACTG CATAGCAGAG GCCAAG'FrGC TGGTGGATGC TGCCTACAAT TGGACCCAGA AGAGCATCAA GCAGCGGCIT r CGCAGCGGTT CAGCCAGCCC CATGGACCTC CTGTCCTACT TCAAACAACC GGTAGCAGCC ACCAGGACAG FrG~rCGGGC CGCAGATTAT ATGCATGTGG CITGGGGCT GCIrGAAGAG AAG'rrACAAC CCCAGCGGTC CGGACC=TC AT-rGTCACTG ATGTGCTAAC AGAACCACAG CTGCGGCTGC TGTCCCAGGC CAGTGGCTGT GCTCTCCGGG ACCAGGCCGA GCGCTGCAGC GACAAGTACC GCACCATCAC TGGACGGTGC AACAACAAGA GGAGACCC= GCTAGGGGCC TCCAACCAGG CTCTGGCTCG CTGGCTGCCC GCCGAGTATG AGGATGGGCT GTCGCTCCCC TrCGGCTGGA CCCCCAGCAG GAGGCGCAAT GG=ICC TCCCTCTrGT CCGGGCTGTC TCCAACCAGA UFGTGCGCTT CCCCAATGAG AGACTGACCT CCGACCGTGG CCGAGCCCTC ATG'ITCATGC AGTGGGGCCA GTFrCA'rrGAC CATGACCTGG ACTTCTCCCC GGAGTCCCCG GCCAGAGTGG CCTJTCACTGC AGGCG'TTGAC TGTGAGAGGA CCTGCGCCCA GCTGCCCCCC TG=rrCCCA TCAAGATCCC ACCCAATGAC CCCCGCATCA AGAACCAGCG TGACTGCATC CC1TCTCC GCTCGGCACC CTCATGCCCC CAAAACAAGA ACAGAGTCCG CAACCAGATC AACGCGCTCA CCTCC1TGT GGACGCCAGC ATGGTGTATG GCAGTGAGGT CTCCCTCTCG CTGCGGCTCC GCAACCGGAC CAACTACCTG GGGCTGCTGG CCATCAACCA GCGCTFCAA GACAACGGCC GGGCCCTGCT GCCC'ICGAC AACCTGCACG ATGACCC~rG TCTCCTCACC AACCGCTCGG CGCGCATCCC CTGCTCCTG GCAGGTGACA CCCGATCAAC GGAAACCCCC AAACTGGCAG CCATGCACAC CCTC1TATG CGAGAGCACA ACCGGCTGGC CACCGAGCTG AGACGCCTGA ATCCCCGGTG GAATGGAGAC AAACTGTACA ATGAGGCTCG GAAGATCATG GGGGCCATGG TCCAGATCAT CACCTACCGA GAC1TCTGC CCCTGGTFCT GGGCAAGGCC CGGGCCAGGA GAACCCrGGG GCACTACAGG GGGTACrGCT CCAATGTGGA CCCACGGGTG GCCAATGTCT TCACCCTGGC C'ICCGCII GGCCACACAA TGCTCCAGCC C=CATGT7C CGCTI'GGACA GTCAGTACCG GGCCTCCGCA CCCAACTCGC ATGTCCCACT TAGCTCTGCC TrC=rGCCA GCTGGCGGAT CGTGTATGAA GGGGGCATCG ACCCCATCCT CCGGGGCCTC ATGGCCACCC CTGCCAAGCT GAACCGTCAG GATGCCATGT TAGTGGATGA GCTCCGGGAC CGGCTGITC GGCAAGTGAG GAGGATTGGG CTGGACCTGG CAGCTCTCAA CATGCAACGA AGCCGGGACC ACGGCcTrCC AGGGTACAAT GCTGGAGGC G=TCTGTGG GCTCTCCCAG CCCCGGAATT TGGCACAGCT TAGCCGGGTG CTGAAAAACC AGGACI'TGGC AAGGAAGTrC CTGAMT=GT ATGGAACACC TGACAACAT7 GACATCTGGA 1TGGGGCCAT CGCTGAGCCT CTITGCCGG GGGCTCGAGT GGGGCCTCTT CTGGC1TGTC TGT7CGAGAA CCAGTTCAGA AGAGCCGAGA CGGAGACAGG TrCTGGTGGC AGAACGAGGT GFTrCACCA AAGACAGCGC AAGGCCCTGA GCAGAATrC CTrGTCTCGA ATTATATGTG ACAATACCGG TATCACCACG GrTrCAAGGG ACATCITCAG AGCCAACATC TACCCTCGGG GCTIGTGAA CTGCAGCCGT ATCCCCAGGT TGAACCTATC AGCCTGGCGA GGGACATGAG GCTCTGCAG GAGTCTATCC CAAGTCTCCA ACTIMGGAG ACAAGGGGAA GGGGAGGACC ATGAGGCTGC CT7GTCTCCC TGGAGCAAGT GCAGGCTCGT GACGC,1rCTG CTGGCTACAG CTCAGAGCTG GGTTCCCCAG CCAGGAGTGA AGGCTGGGGG CTCCTATCAG CAATGGACCT TCCGCCTTGG GAGCCTCrA GGTAT7AGGC TATGAATCAG CGCCACGTGC AAAGGCTGG GAGCCAAGCC ATGTGGTCTI' GCACCCCAGG CAAGAAAAGT CAGCTGGAGG GTrTACAGCA C1TCTACTG TTCCCAGCC CTCCCTCCCC TCCCTCACCA TGACTAAGAG ACCACTCGGT CCTAGCCTCC AGACACCCCA CAATACTCCT CTGAGCCTGA GGCCAGGCAG CATGCTCTGC TTCTACCAAT AAAGCACTGC CGGAATTC-3' (FRAG. NO: 1726) (SEQ. ID NO: 1737) 5'-CACCGCTCCT GTCAGCCAAC AAATATCCAT TGAGCGACAC CTGTGTCCCA GGTGCTGCTC TGGGCCCTGG GAGAAGTGCA TCAGTGGGCTr TGGTAGTAGA GGGTAGGGAT GGAGTGAAGG GTAGGCAGGA AGAATGTCCC CAGGCTGGTA GGAGGTGGGG TGGGGGGTI7 CAGTCTCAAA ACTCCCATGA AAACCAGAGA GAAG17ICAG AACITCCACCC AAGAGGCTrGG GMCTAGGG CCCAGAGCTG CCCTCCCCCA CCCTAGAATG GGCTATAAAA GTCCCFI'CCC AGCTACGTCC AGAGAAGAGC TGGAGGAAGT GAGAGGTCGG CTGGGGGTCC TCAAAGTGAG AGGGGAGCAG AGGATCCTCC CGTGCAGGCT GTGGATGTCA CTCACTlCCC AGCTGGTGAA GCCTCGCrGC AGAGATGCAT CTGCTCCCAG CCCTGGCAGG GGTCCTGGCC ACACTCGTCC TCGCCCAGCC CTGTGAGGGC ACTGACCCAG GTAATAGTCC CCTAGACAGG CAAGGAGGAG GGAGGGGAAA TGGAAGGGGA AGCACTTGGG TCTI7GGAGGG GGTCTTGTGG CTrGCTGAAC CCTGAGTCCC CATCTC1TG AACAGCCTCC CCTGGGGCAG TGGAGACCTC GGTCCTGCGA GACTGCATAG CAGAGGCCAA GTlGCTGGTG GATGCTGCCT ACAAT7GGAC CCAGAAGAGG TGGACTTGGG TCTGGGGGCT GCATGGGCCT GGGAGGATCA GT-3' (FRAG. NO:_)(SEQ. ID NO:2483) 5'-TAATACCT'G TGGGGTCAGG GAGCCCATGT CCCGTGCTGA TGTTAITCC CCACCAGGTC CGGGCTGTCT CCAACCAGAT TGTGCGCTTC CCCAATGAGA GACTGACCTC CGACCGTGGC CGAGCCCTCA TGTrCATGCA GTGGGGCCAG TITCATTGACC ATGACCTGGA CTrCTCCCCG GAGTCCCCGG CCAGAGTGGC C=CACTGCA GGCGTTGACT GTGAGAGGAC CTGCGCCCAG CTGCCCCCC.T GC3TCCCAT CAAGGTACCT ACCCTCAGCC AATCTCCCAT GCCCTTGTGT GGCCTCCCCC AAAGGCAAGG TGCTGGGGGT GGGGATCTGG AAGACTGGAG CACCATCCTr AAGGAGCTGC CTGTGGAGCT AGGGTATGAG ACAGAGACAC AAG-3 (FRAG.NO:_)(SEQ.ID NO:2484) 5'-CACrGTCTCC TCTTCCATCT CAGATCCCAC CCAATGACCC CCGCATCAAG AACCAGCGTG ACTGCATCCC ==CTCCGC TCGGCACCCT CATGCCCCCA AAACAAGAAC AGAGTCCGCA ACCAGATCAA CGCGCTCACC TCCTEGTGG ACGCCAGCAT GGTGTATGGC AGTGAGGTCT CCCTCTCGCT GCGGCTCCGC AACCGGACCA ACTACCTGGG GCTGCTGGCC ATCAACCAGC GCFICAAGA CAACGGCCGG GCCCTGCTGC CCTTCGACAA CCTGCACGAT GACCCCTGTC TCCTCACCAA CCGCTCGGCG CGCATCCCCT GCTTCCTGGC AGGTCAGACA GGGAGGAAGG TGGTGTCITC CCAGGAAACA GCCATCCCTG GGGTCCCAAC TGGGAAGCAA TGGTGGGATG TGGTGAAGGT ACATGGITIG GGACCTCAGT ATTAGGCACA CCATAAGCAT GGATCTGTGC AC-3' (FRAG.NO:_)(SEQ.ID NO:2485) WO 00/09525 PCT/US99/17712 EPI-109 121 5'-TGAAGAGATG GAGGTCCAGT GAGGGCCAGG AGTTTGGCCC ACCCCGTCTC TCCCATCCCC AGCCCTGGGT CTACCCTGGT AGAAAGACAT TTCTCTGGGA AAGGCTGCAG TAAATCTGAG CTTGGGGTTT TCAAGGTGAC ACCCGATCAA CGGAAACCCC CAAACTGGCA GCCATGCACA CCCTCTAT GCGAGAGCAC AACCGGCTGG CCACCGAGCT GAGACGCCTG AATCCCCGGT GGAATGGAGA CAAACTGTAC AATGAGGCTC GGAAGATCAT GGGGGCCATG GTCCAGGTAA GGAGCTCTGC ATCCCAGCAT CCCCC-3' (FRAG.NO:_)(SEQ.IDNO:2486) 5'-CTTTGTATCT CCACCCACCA ATAGTAAATT AATGTGTCA CATTTGACGT GATGACAATA AAGAATATGT CTGAGCCACC CTTGAAAAG GCAAGGGTAT GGGTGAGTAG CCTCTGGGGA ATGTTCCTCC TGTCTTCCCT TCCAGATCAT CACCTACCGA GACTTTCTGC CCCTGGTTCT GGGCAAGGCC CGGGCCAGGA GAACCCTGGG GCACTACAGG GGGTACTGCT CCAATGTGGA CCCACGGGTG GCCAATGTCT TCACCCTGGC CTTCCGCT GGCCACACAA TGCTCCAGCC CTTCATGTTC CGCTTGGACA GTCAGTACCG GGCCTCCGCA CCCAACTCGC ATGTCCCACT TAGCTCTGCC TrTCTTGCCA GCTGGCGGAT CGTGTATGAA GGTGACCAGG 1I ICCAGGG GGCAAATGGG GGTGAGGGTG GGGAGCATGC CCTCCCCTAG GTGG-3' (FRAG.NO:_)(SEQ.ID NO:2487) 5'-TCCAGCTGCT TCATGTCTCT CCAGAACTCT GTTTCCTGAC AAACGTTACT AACATACCCG ACTGGCTTGT CCAGCTCTGG GCTAGCTTGG CATCATGTGA TAACCCAAGT AGCTTCCCAG AGGCTGGTCC AATCTGTGCT GCTCACATTC CCTGCCACCA GGGGGCATCG ACCCCATCCT CCGGGGCCTC ATGGCCACCC CTGCCAAGCT GAACCGTCAG GATGCCATGT TAGTGGATGA GCTCCGGGAC CGGCTGTTC GGCAAGTGAG GAGGATTGGG CTGGACCTGG CAGCTCTCAA CATGCAACGA AGCCGGGACC ACGGCCTTCC AGGTGAGGGG GCTGTCCACC TCTTCTCCCA GCTTTGCTCG GGCCAGGCTG CTCAAGGGGT TCTGGGAAGA CCCTGGTACC-3' (FRAG.NO:_)(SEQ.ID NO:3488) 5'-CGACTGCCTG GTAGGTTCTG GTGGCAGAAA CGAGGTGTTT TCACCAAAAG ACAGCGCAAG GCCCTGAGCA GAATCCTT GTCTCGAATT ATATGTGACA ATACCGGTAT CACCACGGTT TCAAGGGACA TCTTCAGAGC CAACATCTAC CCTCGGGGCT TTGTGAACTG CAGCCGTATC CCCAGGTTGA ACCTATCAGC CTGGCGAGGG ACATGAGGCT TCTGCAGGTA AGGGGAGGCC ACCTCCAGCA CCCTGGGCTG GTTAAGCCTC ACATCCTTCC CTGGATGGAT GGCTGAGTCC TCTTAGGTCT CTAAGCAGAG AAAACAGAAC TTGTCACTAG GTACTCTC CAAGTGGCTT CCCAATGTGC TAGTCTGG GCTGACAGTC AATTCCAGGC CCTAGGACTT TGGGGGGAAA TTAGGAGCAT CCAACTA-3' (FRAG.NO:_)(SEQ.ID NO:2489) 5'-GAATTCCGTG GCCAGGACCC CTGCCAGGGC ACTGACCCAG CCTCCCCTGG GGCAGTGGAG ACCTCGGTCC TGCGAGACTG CATAGCAGAG GCCAAGTTGC TGGTGGATGC TGCCTACAAT TGGACCCAGA AGAGCATCAA GCAGCGGCTT CGCAGCGGTT CAGCCAGCCC CATGGACCTC CTGTCCTACT TCAAACAACC GGTAGCAGCC ACCAGGACAG TTGTTCGGGC CGCAGATTAT ATGCATGTGG CTTGGGGCT GCTTGAAGAG AAGTTACAAC CCCAGCGGTC CGGACCCTTC ATTGTCACTG ATGTGCTAAC AGAACCACAG CTGCGGCTGC TGTCCCAGGC CAGTGGCTGT GCTCTCCGGG ACCAGGCCGA GCGCTGCAGC GACAAGTACC GCACCATCAC TGGACGGTGC AACAACAAGA GGAGACCCTT GCTAGGGGCC TCCAACCAGG CTCTGGCTCG CTGGCTGCCC GCCGAGTATG AGGATGGGCT GTCGCTCCCC TTCGGCTGGA CCCCCAGCAG GAGGCGCAAT GGCTTCCTTC TCCCTCTTGT CCGGGCTGTC TCCAACCAGA TTGTGCGCTT CCCCAATGAG AGACTGACCT CCGACCGTGG CCGAGCCCTC ATGTTCATGC AGTGGGGCCA GTTCATTGAC CATGACCTGG ACTTCTCCCC GGAGTCCCCG GCCAGAGTGG CCTTCACTGC AGGCGTTGAC TGTGAGAGGA CCTGCGCCCA GCTGCCCCCC TGCTTTCCCA TCAAGATCCC ACCCAATGAC CCCCGCATCA AGAACCAGCG TGACTGCATC CCTCTrCC GCTCGGCACC CTCATGCCCC CAAAACAAGA ACAGAGTCCG CAACCAGATC AACGCGCTCA CCTCCTTTGT GGACGCCAGC ATGGTGTATG GCAGTGAGGT CTCCCTCTCG CTGCGGCTCC GCAACCGGAC CAACTACCTG GGGCTGCTGG CCATCAACCA GCGCTCAA GACAACGGCC GGGCCCTGCT GCCCTTCGAC AACCTGCACG ATGACCCCTG TCTCCTCACC AACCGCTCGG CGCGCATCCC CTGCTCCTG GCAGGTGACA CCCGATCAAC GGAAACCCCC AAACTGGCAG CCATGCACAC CCTCTTATG CGAGAGCACA ACCGGCTGGC CACCGAGCTG AGACGCCTGA ATCCCCGGTG GAATGGAGAC AAACTGTACA ATGAGGCTCG GAAGATCATG GGGGCCATGG TCCAGATCAT CACCTACCGA GACTTCTGC CCCTGGTTCT GGGCAAGGCC CGGGCCAGGA GAACCCTGGG GCACTACAGG GGGTACTGCT CCAATGTGGA CCCACGGGTG GCCAATGTCT TCACCCTGGC CTTCCGCTTT GGCCACACAA TGCTCCAGCC CTTCATGTTC CGCTrGGACA GTCAGTACCG GGCCTCCGCA CCCAACTCGC ATGTCCCACT TAGCTCTGCC TTCTTTGCCA GCTGGCGGAT CGTGTATGAA GGGGGCATCG ACCCCATCCT CCGGGGCCTC ATGGCCACCC CTGCCAAGCT GAACCGTCAG GATGCCATGT TAGTGGATGA GCTCCGGGAC CGGCTGTTC GGCAAGTGAG GAGGATTGGG CTGGACCTGG CAGCTCTCAA CATGCAACGA AGCCGGGACC ACGGCCTTCC AGGGTACAAT GCTTGGAGGC GCTrCTGTGG GCTCTCCCAG CCCCGGAATT TGGCACAGCT TAGCCGGGTG CTGAAAAACC AGGACTTGGC AAGGAAGTTC CTGAATTGT ATGGAACACC TGACAACATT GACATCTGGA TTGGGGCCAT CGCTGAGCCT C1111GCCGG GGGCTCGAGT GGGGCCTCTT CTGGCTTGTC TGTTCGAGAA CCAGTTCAGA AGAGCCGAGA CGGAGACAGG TTCTGGTGGC AGAACGAGGT GTTTCACCA AAGACAGCGC AAGGCCCTGA GCAGAATTC CTTGTCTCGA ATTATATGTG ACAATACCGG TATCACCACG GTCAAGGG ACATCTTCAG AGCCAACATC TACCCTCGGG GCTTTGTGAA CTGCAGCCGT ATCCCCAGGT TGAACCTATC AGCCTGGCGA GGGACATGAG GCTTCTGCAG GAGTCTATCC CAAGTCTCCA AC1TTTGGAG ACAAGGGGAA GGGGAGGACC ATGAGGCTGC CTTGTCTCCC TGGAGCAAGT GCAGGCTCGT GACGCTTCTG CTGGCTACAG CTCAGAGCTG GGTTCCCCAG CCAGGAGTGA AGGCTGGGGG CTCCTATCAG CAATGGACCT TCCGCCTTGG GAGCCTCTTA GGTATTAGGC TATGAATCAG CGCCACGTGC AAAGGCTTGG GAGCCAAGCC ATGTGGTCTT GCACCCCAGG CAAGAAAAGT CAGCTGGAGG GTTTACAGCA CTTTCTACTG 'TTCCCAGCC CTCCCTCCCC TCCCTCACCA TGACTAAGAG ACCACTCGGT CCTAGCCTCC AGACACCCCA CAATACTCCT CTGAGCCTGA GGCCAGGCAG CATGCTCTGC TTCTACCAAT AAAGCACTGC CGGAATrC-3' (FRAG.NO: ) (SEQ.ID no:2490) 5'-TC GGC CTG GTC CCG G-3' (FRAG. NO: 1727) (SEQ. ID NO:1738) 5'-TGG GGG T1T CCG TTG-3' (FRAG. NO: 1728) (SEQ. ID NO: 1739) 5'-TG GTC CCG GBG BGC -3' (FRAG. NO: 1729) (SEQ. ID NO: 1740) 5'-GCG CTC GGC CTG GTC CCG G-3' (FRAG. NO:1053) (SEQ. ID NO:1063) 5'-GGG TCT CCT CTT GTT GTT GC-3' (FRAG. NO:1054) (SEQ. ID NO:1064) 5'- TTG CGC CTC CTG CTG GGG GT CC-3' (FRAG. NO:1055) (SEQ. ID NO:1065) 5'-CTC TGT TCT TGT TT GGG GGC-3' (FRAG. NO:1056) (SEQ. ID NO:1066) 5'-GGG CCC GGC CGT TGT CU G-3' (FRAG. NO:1057) (SEQ. ID NO:1067) 5'-GTT TGG GGG TT CCG TTG-3' (FRAG. NO:1058) (SEQ. ID NO:1068) 5'-GGG TTC TCC TGG CCC GGG CCT TGC CC-3' (FRAG. NO:1059)(SEQ. ID NO:1069) 5'-GGC CGT GGT CCC GGC TTC GTT GC-3' (FRAG. NO:1060) (SEQ. ID NO:1070) 5'-CCT GTC TCC GTC TCG GCT CTT CTG-3' (FRAG. NO:1061) (SEQ. ID NO:1071) WO 00/09525 PCT/US99/17712 EPI-109 122 5'-GGG CCT TGC GCT GTC TTT GGT G-3' (FRAG. NO:1062) (SEQ. ID NO:1072) 5'-GCB CCG TCC BGT GBT GGT GCG GTB CTT GTC GCT GCB GCG CTC GGC CTG GTC CCG GBG BGC -3' (FRAG. NO:1063) (SEQ. ID NO:1073) Human Intercellular Adhesion Molecule-1 (ICAM-1) Nucleic Acid and Antisense Oligonucleotide Lragments 5'-GCG CGG GCC GGG GGC TGC TGG G GGT TGG CCC GGG GTG CCC C GCC GCT GGG TGC CCT CGT CCT CTG CGG TC GTG TCT CCT GGC TCT GGT TCC CC GCT GCG CCC GTT GTC CTC TGG GGT GGC CTT C GCT CCC GGG TCT GGT TCT TGT GT TGG GGG TCC CTT TT GGG CCT GTT GT GGC GTG GCT TGT GTG TTC GGT TTC TGC CCT GTC CTC CGG CGT CCC CGG BGC CTC CCC GGG GCB GGB TGB CTT TTG BGG GGG BCB CBG BTG TCT GGG CBT TGC CBG GTC CTG GGB BCB GBG CCC CGB GCB GGB CCB GGB GTG CGG GCB GCG CGG GCC GGG GGC TGC TGG GBG CCB TBG CGB GGC TGB G-3' (FRAG. NO: 1730) (SEQ. ID NO: 1741) 5'-GGG GGC TGC TGG G-3' (FRAG. NO: 1731) (SEQ. ID NO:1742) 5'-T GTC CTC CGG CGT CCC-3' (FRAG. NO:1732) (SEQ. ID NO:1743) 5'-G CCB TBG CGB GGC TGB G-3' (FRAG. NO: 1733) (SEQ. ID NO: 1744) 5'-CTC TGG GGT GGC CT' C-3' (FRAG. NO:1734) (SEQ. ID NO:1745) 5'-GCG CGG GCC GGG GGC TGC TOG G-3' (FRAG. NO:1064) (SEQ. ID NO:1074) 5'-GGT TGG CCC GGG GTG CCC C-3' (FRAG. NO:1065) (SEQ. ID NO:1075) 5'-GCC GCT GGG TGC CCT CGT CCT CTG CGG TC-3' (FRAG. NO:1066) (SEQ. ID NO:1076) 5'-GTG TCT CCT GGC TCT GGT TCC CC-3' (FRAG. NO:1067) (SEQ. ID NO:1077) 5'-GCT GCG CCC GTT GTC CTC TGG GGT GGC CTT C-3' (FRAG. NO:1068) (SEQ. ID NO:1078) 5'-GCT CCC GGG TCT GGT TCT TGT GT-3' (FRAG. NO:1069) (SEQ. ID NO:1079) 5'-TGG GGG TCC CTT TTT GGG CCT GTT GT-3' (FRAG. NO:1070) (SEQ. ID NO:1080) 5'-GGC GTG GCT TGT GTG TTC GGT TTC-3' (FRAG. NO:1071) (SEQ. ID NO:1081) 5'-TGC CCT GTC CTC CGG CGT CCC-3' (FRAG. NO:1072) (SEQ. ID NO:1082) 5'- CGG BGC CTC CCC GGG GCB GGB TGB CTT TTG BGG GGG BCB CBG BTG TCT GGG CBT TGC CBG GTC CTG GGB BCB GBG CCC CGB GCB GGB CCB GGB GTG CGG GCB GCG CGG GCC GGG GGC TGC TGG GBG CCB TBG CGB GGC TGB G-3' (FRAG. NO:1073) (SEQ. ID NO:1083) Human Vascular Cell Adhesion Molecule 1 (VCAM-1) Nucleic Acid and Oligonucleotide Fragments 5'-CCT CTT TTC TGT T TCC C CTC TGC CTT TGT TG GGT TCG CTr CCT TTC TGC TTC TTC C CTG TGT CTC CTG TCT CCG CTT TTT TCT TC GTC TT GTT GTT TTC TCT TCC TG CTG BGC BBG BTB TCT BGB TTC TGG GGT GGT CTC GBT TTT BBBB GCT TGB GBB GCT GCB BBC BTT BTC CBB BGT BTB TTT GBG GCT CCB BGG BTC BCG BCC BTC TTC CCB GGC BTT TTB BGT TGC TGT CGT-3' (FRAG. NO: 1735) (SEQ. ID NO: 1746) 5'-C TGT CGT-3' (FRAG. NO:1736) (SEQ. ID NO:1747) 5'-TGC TTC TTC C-3' (FRAG. NO:1737) (SEQ. ID NO:1748) HSVCAM1AS1: 5'-CCT CTT TTC TGT 'IT TCC C-3' (FRAG. NO:1074) (SEQ. ID NO:1084) HSVCAM1AS2: 5'-CTC TGC CT] TGT TTG GGT TCG-3' (FRAG. NO:1075) (SEQ. ID NO:1085) HSVCAM1AS3: 5'-CTT CCT TTC TGC TTC TTC C-3' (FRAG. NO:1076) (SEQ. ID NO:1086) HSVCAMlAS4: 5'-CTG TGT CTC CTG TCT CCG CTT TTT TCT TC-3' (FRAG. NO:1077) (SEQ. ID NO:1087) HSVCAM1AS5: 5'-GTC 'T GTT GTT TTC TCT TCC TTG-3' (FRAG. NO:1078) (SEQ. ID NO:1088) CTG BGC BBG BTB TCT BGB TTC TGG GGT GGT CTC GBT TTT BBBB GCT TGB GBB GCT GCB BBC BTT BTC CBB BGT BTB T=T GBG GCT CCB BGG BTC BCG BCC BTC TTC CCB GGC BTT TTB BGT TGC TGT CGT (FRAG. NO:1079) (SEQ. ID NO:1089) Human Endothelial Leukocyte Adhesion MoleculejELAM-1) Nucleic Acid and Antisense Oligonucleotide Fragments 5'-BBG TGB GBG CTG BGB GBB BCT GTG BBG CBB TCB TGB CTT CBB GBG TTC TTT TCB CCC GTT CTT GGC TTC TTC TGT C CGT TGG CTT CTC GTT GTC CC TGT GGG CTT CTC GTT GTC CC CCC TTC GGG GGC TGG TGG GGC CGT CCT TGC CTG CTG G GTT CT GGC TTC TTC TGT CCG T TGG CTT CTC GTT GTC CC TGT GGG CTT CTC GTT GTC CC CCC TTC GGG GGC TGG TGG GGC CGT CCT TGC CTG CTG G CCTGAGACAG AGGCAGCAGT GATACCCACC TGAGAGATCC TGTGTTTGAA CAACTGCTTC CCAAAACGGA AAGTATITCA AGCCTAAACC TTTGGGTGAA AAGAACTCTT GAAGTCATGA TTGCTrCACA GTTTCTCTCA GCTCTCACTT TGGTGCTCT CATTAAAGAG AGTGGAGCCT GGTCTTACAA CACCTCCACG GAAGCTATGA CTTATGATGA GGCCAGTGCT TATTGTCAGC AAAGGTACAC ACACCTGGTT GCAATTCAAA ACAAAGAAGA GATTGAGTAC CTAAACTCCA TATTGAGCTA 'TCACCAAGT TATTACTGGA TTGGAATCAG AAAAGTCAAC AATGTGTGGG TCTGGGTAGG AACCCAGAAA CCTCTGACAG AAGAAGCCAA GAACTGGGCT CCAGGTGAAC CCAACAATAG GCAAAAAGAT GAGGACTGCG TGGAGATCTA CATCAAGAGA GAAAAAGATG TGGGCATGTG GAATGATGAG AGGTGCAGCA AGAAGAAGCT TGCCCTATGC TACACAGCTG CCTGTACCAA TACATCCTGC AGTGGCCACG GTGAATGTGT AGAGACCATC AATAATTACA CTTGCAAGTG TGACCCTGGC TTCAGTGGAC TCAAGTGTGA GCAAATTGTG AACTGTACAG CCCTGGAATC CCCTGAGCAT GGAAGCCTGG TTTGCAGTCA CCCACTGGGA AACTTCAGCT ACAATTCTTC CTGCTCTATC AGCTGTGATA GGGGTTACCT GCCAAGCAGC ATGGAGACCA TGCAGTGTAT GTCCTCTGGA GAATGGAGTG CTCCTATTCC AGCCTGCAAT GTGGTTGAGT GTGATGCTGT GACAAATCCA GCCAATGGGT TCGTGGAATG TTTCCAAAAC CCTGGAAGCT TCCCATGGAA CACAACCTGT ACATTGACT GTGAAGAAGG A'1TTGAACTA ATGGGAGCCC AGAGCCTTCA GTGTACCTCA TCTGGGAATT GGGACAACGA GAAGCCAACG TGTAAAGCTG TGACATGCAG GGCCGTCCGC CAGCCTCAGA ATGGCTCTGT GAGGTGCAGC CATTCCCCTG CTGGAGAGTT CACCTTCAAA TCATCCTGCA ACTTCACCTG TGAGGAAGGC TTCATGTTGC AGGGACCAGC CCAGGTTGAA TGCACCACTC AAGGGCAGTG GACACAGCAA ATCCCAGTTT GTGAAGCTTT CCAGTGCACA GCCTTGTCCA ACCCCGAGCG AGGCTACATG AATTGTCTTC CTAGTGCTTC TGGCAGTTTC CGTTATGGGT CCAGCTGTGA GTTCTCCTGT GAGCAGGGTT TTGTGTTGAA GGGATCCAAA AGGCTCCAAT GTGGCCCCAC AGGGGAGTGG GACAACGAGA AGCCCACATG TGAAGCTGTG AGATGCGATG CTGTCCACCA GCCCCCGAAG GGTTTGGTGA GGTGTGCTCA TTCCCCTATT GGAGAATTCA CCTACAAGTC CTCTTGTGCC TTCAGCTGTG AGGAGGGATT TGAATTATAT GGATCAACTC AACTTGAGTG CACATCTCAG GGACAATGGA CAGAAGAGGT TCCTTCCTGC CAAGTGGTAA AATGT]CAAG CCTGGCAGTT CCGGGAAAGA TCAACATGAG CTGCAGTGGG GAGCCCGTGT WO 00/09525 PCT/US99/17712 EPI-109 123 TTGGCACTGT GTGCAAGTTC GCCTGTCCTG AAGGATGGAC GCTCAATGGC TCTGCAGCTC GGACATGTGG AGCCACAGGA CACTGGTCTG GCCTGCTACC TACCTGTGAA GCTCCCACTG AGTCCAACAT TCCCTTGGTA GCTGGACT CTGCTGCTGG ACTCTCCCTC CTGACATTAG CACCATTTCT CCTCTGGCTT CGGAAATGCT TACGGAAAGC AAAGAAATTT GTTCCTGCCA GCAGCTGCCA AAGCCTTGAA TCAGACGGAA GCTACCAAAA GCCTTCTrAC ATCCTTTAAG TTCAAAAGAA TCAGAAACAG GTGCATCTGG GGAACTAGAG GGATACACTG AAGTTAACAG AGACAGATAA CTCTCCTCGG GTCTCTGGCC CTTCTTGCCT ACTATGCCAG ATGCCTITAT GGCTGAAACC GCAACACCCA TCACCACTTC AATAGATCAA AGTCCAGCAG GCAAGGACGG CCTITCAACTG AAAAGACTCA GTGTTCCCTT TCCTACTCTC AGGATCAAGA AAGTGTrGGC TAATGAAGGG AAAGGATATT TTCTTCCAAG CAAAGGTGAA GAGACCAAGA CTCTGAAATC TCAGAATTCC TITTCTAACT CTCCCTTGCT CGCTGTAAAA TCTTGGCACA GAAACACAAT ATTGTGGC TTTCTTCTT TTGCCCTTCA CAGTGTTTCG ACAGCTGATT ACACAGTTGC TGTCATAAGA ATGAATAATA ATTATCCAGA GTAGAGGA AAAAAATGAC TAAAAATATT ATAACTTAAA AAAATGACAG ATGTTGAATG CCCACAGGCA AATGCATGGA GGGTTGTTAA TGGTGCAAAT CCTACTGAAT GCTCTGTGCG AGGGTrACTA TGCACAA'TT AATCAC=TTC ATCCCTATGG GATTCAGTGC TTCTTAAAGA GTTCTTAAGG ATTGTGATAT ITTACTrGC ATTGAATATA TTATAATCTT CCATAC'TCT TCATTCAATA CAAGTGTGGT AGGGACTTAA AAAACTTGTA AATGCTGTCA ACTATGATAT GGTAAAAGTT ACTTATTCTA GATTACCCCC TCATTGITTTA TTAACAAATT ATGTTACATC TGTTTTAAAT TTA TTCAAA AAGGGAAACT ATTGTCCCCT AGCAAGGCAT GATGTTAACC AGAATAAAGT TCTGAGTGTr TTTACTACAG T'rGTITITrG AAAACATGGT AGAATTGGAG AGTAAAAACT GAATGGAAGG TTTGTATATT GTCAGATATr TTTCAGAAA TATGTGGTTT CCACGATGAA AAACTTCCAT GAGGCCAAAC GTTTTGAACT AATAAAAGCA TAAATGCAAA CACACAAAGG TATAATTTTA TGAATGTCTT TGTTGGAAAA GAATACAGAA AGATGGATGT GCTTrGCATr CCTACAAAGA TGTTTGTCAG ATGTGATATG TAAACATAAT TCTTGTATAT TATGGAAGAT TTTAAATTCA CAATAGAAAC TCACCATGTA AAAGAGTCAT CTGGTAGATT TTTAACGAAT GAAGATGTCT AATAGTTATr CCCTATMTGT TTTCTTCTGT ATGTTAGGGT GCTCTGGAAG AGAGGAATGC CTGTGTGAGC AAGCATTTAT GATTATAT AAGCAGATTT AACAATrCCA AAGGAATCTC CAGTCAG TTGATCACTG GCAATGAAAA ATTCTCAGTC AGTAATTGCC AAAGCTGCTC TAGCCTTGAG GAGTGTGAGA ATCAAAACTC TCCTACACTT CCATrAACT AGCATGTGTT GAAAAAAAAA GTTTCAGAGA AGTTCTGGCT GAACACTGGC AACGACAAAG CCAACAGTCA AAACAGAGAT GTGATAAGGA TCAGAACAGC AGAGGTTCTT TTAAAGGGGC AGAAAAACTC TGGGAAATAA GAGAGAACAA CTACTGTGAT CAGGCTATGT ATGGAATACA GTGTTATT CTTTGAAATT GTTTAAGTGT TGTAAATATT TATGTAAACT GCATTAGAAA TTAGCTGTGT GAAATACCAG TGTGGTTTGT GTfTGAGT'TT TArTGAGAAT TTTFAAATTAT AACTTAAAAT ATTTTATAAT TTTAAAGTA TATATATT TAAGCTTATG TCAGACCTAT TTGACATAAC ACTATAAAGG TTGACAATAA ATGTGCTTAT GTTT GATCAAAATT TTrACCrATT ATGCATITGA TATATAAATA AGTATATAAA TGCACACACA GACACAGCAA TGATGGTGAA CAGTCTTCAT ACAATTATAT GGATGAATCT CATAAAATGC TGAGTTAAAG AAATCAGACC AAAGAACATA TACTGAAAGA TTCTCTCTAT ATACAAAGTr CAAAAATAGG TGGACCAATr CATGGTGGTG TTAGAAATCA GAAGAGAGGC TACCTTTGTG GGGAGGGGAC AGTTTAATGC CCAGAAGCGG TAAATAAGGA ATCCTCTGGG GAGTGGTAAT GATCTGGATG CTGGCTACAG GATGTGTTGG TTGTAAAAAT GCA-FITITTT ATATCTAGCT TTTCCATGT GTATATTATA CTTCAAAGAA GTTCAGTTAA TAATT7CTCA TGTCACTGTA GAGTAGCTCA GTTAGCCCCA GCAAGCCTCT GGCTTAATCT TGTTACCT TAAGCCATCA GTCAITACA AGTAGGAAAA T7CACAGGGA AAGTTAGAGT ATAAAATCCA GAATGAAGGT TTACTGGGTA AGAGTCTCTC CAT=TTCCAA AGCCCGTTTA TTTCTTGATT CCAGTTCTTA AGAAGTCTCA GCATTGTGTC TITI=CATGT ATCTTACAAG AAGACAGCAT GTGCTTCTAA CACCTGATAC ATTGTATCTA CCAGCACTTG GTAAACAGAA AAGAACCACA -ITTMCTTGT AGGAGAAATT TGGTGCCTAT TTCCTACCAG GCACCAATAA GTGGGACCAA TAGGTGGGAT TAAAGATACA GTAGAAAGTA TTAAAACTT GCCAGGGGGC AATAGTCTGA AAATAAGTAA ATrGGTGCTA TAGAATGGAA GTTACAGGCT TCTTr 1- TTCCCACAAG ATCTGCTCCT TGAGCCCCTA GAGAClTIC TGTCTGTTAC TGTTTCTTCA TTCCTCATCT GCAGAGCCAG CCCTGAGAAG TGCAGACCAA AGCCAGGGAA GGCTCTGCAA AGATGTACAA ATGGAAGTCA CCTTAATAAC CTCTGACTGC TGCGCATAAT ACATTCACT CAAAAGAGGG GTTAAACAAT GGAACAGAAT ACAGAGGCCA GAAATAATGC TGAACACTGA CAACCATCTG ATCTTGACA AAATCCACAA AAACAAGCAA TGGAGAAAGG ACTCCCTATT CCATAATGGT GCTGGGATAA CTGTCTAGCT ATATACAGAA GATTGAACCT GGGCCCCTTC CTTACATCAT ATACAAAAAA TAACTCAAGA TGGAGTAAAG ACTrAAATCT AAAACCAAAC ACTATAAAAA CCCTGGAAGA TAGCCTGGGA AATACCATTC TGGACATAGG ACCTGGCAAA GACTTCATGA CAAGACACCA AAAGCAATAG CAACAAAAAC CAAATTGACT AATGAAACTA ATGAAACTCT TTAGTTGTAC AACAGATAGT TTATCTGTAC AACAAAATAA ACTATCAACA GAGTAAACAA CCTACAGAAT GGAAAAATITT ITGCAAACT ATGCATCTGA CAAAGGTCTA ATATCCAGAA TCTATAAGGA ATTrAAACAA ATTTACAAGC AAAAAAATGA CCTCATTAAA AAGTGGGCAA AGGACATGAA CAGATGCT TCAAAATAAG ACATTCACAC ATCCAACAAC CATATGAAAA GATGTTAAC ATCACTAATC ATTAGAGGAA TACAAATCAA AAGCATAATA AGATACCATC TAATACCAGT AGGAATGACT ACTATTAAAA AGTCAGACAA TAACAGATGC TGGTGAAGGT TGTGGAGAAA AGGGAATGTT TATGCACTGC TAGTGGGAAT GTAAACTAGT TCAGCCATTG TGGAAGAGAG TGTGGTGATT CCTCAAAGAA TGTAAAACCG AACTGCCTTT CAATCCAGCA ATCCCATTAT TGGATATACA CCAAAAGGAA TAGAAATTGT TTTACCGTAA AGGCGCATGC ATGCATATGT TCATTACAGC ACTATTrACG ATAGCAAAGA CATGGAATCG TCTAAATGCC CATCAGTGGT AGACTAGCTA AAAAAAAAAA AATGTGGTAC ATATACATCA CAGAATAGTA TGCAGCCATA AAAATGAACA AGATCATCAT GTCCTGCA GCAACATGGA TGTAGTrGGA GGCCATrATC CTAAGCAAAT TAATGCAGGA ACAGAAAGCC AAATACCACA TGTTCTCATT TATAAGTGAC AGCTAAATAT TGAGTACACA TGGACACAAA GAAGGGAACA ATAGACATGG GACCTACTTG AGAATAGAGG GTGGGAGGAG GGTGAGGATC AAAAAGTACC CATAGGACAC TGTGCTTATT ACCTGGGTGA TGAAATAATT TGCACACCAA ACCCCTGTGA CACACAATTT ACCTATATAG AAAACCTGTG CATGTACCCC TGAACCTAAA AGTTAATGGT GGGGGGGTGG GGTTAAGCTA CTTGTGGTA TAAATCTGAG CATTCATATT AAAATAAAAT ATTTACCTCA TrAGAGTAAT TAACATTTAT TAAGCAAAGA GCCAAGTACC TrACACACAT GATGTAAT CTCACAATGA TCTTTAATCT CATAACAACC GTCCATTGTA TGTACATATG TGGAAATTGA GCCTGGAGA GATTAAATGC ATGGGGCATG CCATT7GACT AGAAACTGGA AGCATCAGGA TTAAACTCA GTTCTGAATG GTTTGTAGG CTTTGTTT TCCACATTAT AGCATGGCCT GCCATGAAGA ACAGGTCCTT TCTGGTGTT GTCTTG'TG GTTAAGTGA AGCAAATATT TATAAATA TTCAAGATAT GCTGTTAAAT TTACTCAA AAAT'1TGAGT ACAGTATGGA TCTTCTGAAG CCAAATAACT CTTATTCAAT GCTTAGTTGA GAAATTAT GGAGTAGTTC TCAA'IillA TGTAGTTCCA CTGCAAAGGT AAGTCTTATG GAAAGATTCA CTGTAATTTT TTTCCTCAT TTGGACATCA GCrIiCTT TrCCTCAGAC CCGCTGAAAG ATAA1T1TiA AAATAAAAAC CTTTi A TATCAAGTGG GGACATTT TCCAAATGAA AACCGTGTAT TCATTTTATA TGATAAAATC AATGTTATTA TfTAAAAT TTTGATTFAA AAATCATTAA AAATAAATTT TCAGATATTA CCTGAAATTC TACCATCCAG AGATAATAGT GCTTAAAGAT TTGATATATA GACACACACA CATATATACA TATATATCAT CCTAAACTTC TTTGTATAAA TGTATATAAA GTTAATA AAAACTAGGA GATTAATGCC WO 00/09525 PCT/US99/17712 EPI-1 09 124 CT=GAATGA AAATAAATAC AATGTGTATG CI=AACATC TrGCCT=AC T'17ATAACAT TTATCACAGC AGTCATGAGA TAATGATIA CATGGTCATT G~rAGTAAGC TAATAGCTAA GTGCATGAAC TCTGGAGCTA GCCTCCCTGG AITIAATCC CAGATCTGTC ACTGACCAGC TGAGCAATAC TAGGTAAATT GCTCTTG3TTC CTrAG'IMCT TCATCTGTAA AATAGAGATA AAAATAATAT CCACCTCATA GGATTGGTGT GAGCK11TAAA TGAGCATACG TATGTAGGCC ACTTAACAAC AATGCC~rCA CATACTGAAC ACAAATATAC GAGCTGTFFGT CTTATrGGGC TCATG'TI= CCTACCACTA AGCCGCATGC ATGCAAGGAC CATGTTGG'I1 'TGTTCCACA T7GCATCCCC AACCTGGTAT ACAGTGTGCA TCAATAGTT GTrGACTArI' AITrACTAGTG GCAYITAACA AATATCTG~r AAATGAGTGA AGAAATACCC AYTACTGCA AGTGTGTCTA ATIT7GATGG CATAATGGGG GAAACTCAAA CTCTGGAGTC AAACAGG'IM TAAAACCTrA 'FrCCCTCATC CTCAGT7A Ff GACGTT =FTGGCAGG TGTGTGTGTG GGACAACT7A T-rGAAC'fT CTGAAM~CC AGC'ITCGCAT ATATAAAATA GAGATAGTGA 717CArTC'rrG CAATGTATGG ATIGAGACA A'FrGTGTAAG 'ITrATCAATA AATAGTAGCT AT=ITGTAT AAGTATTACA TATAATATCC AGGCCACTGC 'TTrGCATAAC CCAAAAGGGG CACCATFCAT GCAGAATACA ACATAAATGG TGTCCCTGGA GCAGTGCAGT ATAGGAACCC TGAGGGGACC TACAGTATAC 7TATAGT-rC ATAGA17ACA AA FrATCCCT TTATCAGAGT CTCTCAAGGT TGGATGTAT'r TGAGGTCCAT AAGAGCAA~r TAGGATrAAC AGTAGCTGCA GAAACCATCT GCAGTGATAT TcTCATITA AATCCGCGGG AAAGAAGACA GCTATAAACT TGGGACCTGG G717AAGCAT MIIAAATGCC AAG'17CACCA YITCTAAAA CACAACAAAT ACCCAGTGAG AGAGGGAGAA GGGAAGTAAA TGCCTCTGAA TAAGCAAGT7 AATGTCAGTA GTTGTACTGT ATGCATATTG ATGAACAATA GAGGAACCAA TGTCCAATCA GATGAGCAGG ATATITGGCA ATAACAAGTT GCCT=GAGG AAAAATGA'Fr TrC7rGGCAA GTT='~ATC AGCATrACAA AGCTAAAAGC TACGCTATC ATCACTTATA CTAGCATACC CTGT7GTGCA AATGCTGTCT GTGTGCAT CTGCTATTGT TGATGCCTGG TGCATGAATC AGGACTCCAG CCCACAAG7F FFCCCAGAAC TT7CT7ATGG CCATCAT=T TAAGTGTCTG GTGAACAGTC ATAGM~GGT ACACAAAAGG GTCAACCTGG GGGATGGCTA GGG ITTGACT CAGTCGTrAC ATITCAATAG AGCAGGAAGG GGAAATGGTG GCCTGTAACC TCAGGGAAT7 T-rGCCAGT'TG GTCCACCCCA CTCTCTCTCT CCTGCTCTGA GGAAGTGGCA CAGCCTAGAA CAGCACCACA GGTGAGAGAA ATGCAAACCC TAACCAGAGA AGCAGACTCT TrGCCAGTAG TAATAGrrCA GGACCACCAC CAGCTMAT TAAAATT= AATAACACTC AAGTAT7GGC AGAAAGAAAT AATCTGGGT TAACTATAAC TAGAATAT7G ACTCITCCTC TGTGGAAGAA TCAGCCAATC ACAIT7G~r7 ACATCAGTTC CCCTGAAGAA GAAAAATACA CTGATGTlGC AGCAAGACAA ATFAAGCTA GATGTAAATA AC=CCA GCCTGTAATG CTAGGCTAAT TACATA'ITGG AACTA T1T TCAGGGAAGA A'FrGTGTAGG G'ITCAGGGA AGAATTCTGA AGAAAATATA GAGCTGAAAT GAT=~GCAG CTCACTGAAA CTGCAGGGTT TAGATCCACA CTGATACTCG TTCTATTATC ACTGTAATGA AGGCTGATGG AATAAGTAAA AATGTIIGT ATTAGTATGT =IrACACTT ATITGCAAGG CATAAATAGG TTAGGTI=G ATCTFAA TT AAT7CTAACA TGTATGTGC ACAAGCTGTG AGCAGTITC AGGAGTTAGG TATCTGGCCA TGACTGAMT T7CAGGAGTT AATCATCTGG TAGAAGGGTC ATACACAATA GGAAGATGTG TGTGACAGGT TGTGATCATT ACTATAATCA CACAGAGAGC TGTAGAA'1T TAGGCTGGCA GGGTGGCTCA CGCCTGTAAT CCCAGCACT TGGGAGGCCA AGGCAGGCGG ATCAAGAGGT CAGGAGATGG AGACCATCCT GGCTAACACG GTGAAACCCC GTCTGTACTA AAAATACAAJ\ AAAAAAAAAA AGCCAGGCGT GGTGGTGGGC GCCTGTAGTC CCAGCTAC= GGGAGGCTGA GGCAGGAGAA TGGCGTGAAC CCGGGAGGTG GAGCTTGCAG TGAGCCGAGA TCGCATCACT GCAATCCAAC CTGGGCGACA GAGGGAGACT CAGTCTCAAA AAAAAAAAAA AAAAAAAGTC ATGTTAGATC CAGAGGGGTA GCAACTGGGG CTGGGCTGTC AGTCAACTCA GTCAACTCAG TCAACTCTGC TCCCCCACAG GAGATGCCAG TGATGCAM TCATGGCCAA CATITGTCAGT CAGCATCAITF GAAITACTCC TGA'ITATAGA GACACAGCTG CAAACGATTC CCCAT7AAAT ATGATG TTC TFGCAATGT7 TGGAAGGTAC TCC'rITAG TAAGGGAAAT CCCCTCTI7CT GG=~GCTGA AAGFITI=C FI1CCA=1P AAAAATCGTG AATrCCF1T TGCAATATTG AGGTGGrrAT ATGGM~CTC T7CTCTAATC TGTTAATATG GTGA M AAT GGTlAGAAAT MTAATGT AAATrCCACT CATAT7GCAG AAATAAACCT AAACTGAGCA TGAGGCTATA 7f1TTAT GCTCTATAT TrFGGT'rGCTA TACAGTATTA TGTTAAGAT TTGTrCACAT ATA'IrrGTGA ATGGGATrGG ACTATITC =TCT'TGCCG A7FI=ATCT GGTITAAA TTAAGGATAT 'IMAGAC17A TGAAATATr GGCAAACAAT CC=GGCAAG TAATITMTG GGGAAT1T7GT TITGGCTArr TTGAGTA FFA CCCAATATAT Tr7AATTrAAG 'FrA rCFTAA TG=FTCT7A ATTAAAAAAA 7rACCTACTC TAGAGATATT CI=ATGTAC TCCAGATIT GTCTA'IMAT ACCACI=C TPTF=CCTC GATGAGTGTC ATAGATGUTC ATCTA'TT 7rATCTI7T= TGATCTITCTC 'FrATITCCT7G T"I7CTATTAA CrGAAGT rrTA=~TT CTTT1TCCA CTTCC17ATG G1TAT7CTT TCAATIT=C TCTAACTTCT TAAGTTGGGT GMTAAITI TAG C=GC'rr TGC'mII II A GGATAAGCAT TAAAACTACA AATI=CCTT GTTATFCTI TGCTGCACCC CAAAYrGTFG ATAM~CTAT TGTCTAATI CTAT7CAA'rr AGAATAC'= AAAGTITCTI' 'T1GG'TTM AAAAACTAAC TTIM AAA'Fr GACAAATAAA AATTGTGTAT ATMATTGTG CACAGCATAT GGC=rGAAA TATATGTACA T7GTGGAATG GCrAAA'IMA GCT7ATTAAT GTATGCA11A TCTCACATAC rrATCA=1T TTGTGGTGAG AGCTATGTGA CTIIGAACT TATGAGTTAT 'FrAAATATIT TTAAATrAT'T AAGCATATrG GGATITAAG TAAMTACCT tITAT7ATr AACYTATAAC AAGTAGAACA G FTAACCTGT ATGATTCTAC ATCAT7GAAA TI7ATrGACA TIT7GCF7CAT AGTCTAflAT ATGGTCTACT MT FCATG TI7ACATCTGT AGTAGAATTG GCTAATAG~r GAGTAAAGTA CACATATGTC TATGAAATCA AGTGTAATCC AGAGAAAAAG AGAAA'IMAC TGAATATATT GTTrCTAGGTG CTAT7ATATG TTGTCATGTT TAATCCTCAC CACAATI'GTA TGAGGCAGCC ATAATTAATT CCA=ITACA CATGAGGAGC CrGAGGG FrA AAAAAAAAGC TAGCTCTACT A1TITGTAAAG AATGAAGCAA AGATACAAAT GAAGGCCCAC ATATCCTATA ACTAGATA IT TAAGCATFF AATTCAAGCT TTAAAACTGC TAAATAAAAT GTGCTCCAAT TTCTATATTG ACAGACATAC C=CCTAATG AGCTGGGG Fr CGAA TrAGA AATCTIGAT G=TCAGAGT CCACACTGAA ATGTGGAGGC ACATAGTGAG T7GGTCCCCA GCCTTCAGTC CACCCACC= CTCT=ACTA AATCACC1T CACATACATG TATGAACACC CCAGCCTrCCA AGTCCAAACC CTAAACAAAA TGGGACACCC TrGTGCATAC ACAGAGACAC AGCCCATCCT CAGGAAAACC TGGAAAAGTC CATACAAGTT CTGGAAGCAA GCTTGGGACG G~FrCAGTAG TGTGGTCTAT AAGGGAGGCC TCAGAAGACA GGTI=CT7A ATTCTGTGAA CTCTCCCAC AGTAGAAAGG GTGCTGGAGG AGGGTCAGAG TGAGGACTTC TAAAGCATGG GTCCTGAGTA GGGGCCACTC TTGCCCAAGT CTAAGAAGGG TACTAGAATA GCACACTACT ACTAGATACT AGAACCCAGA TACAAGCACA GGTCTCTGA AATrAATAAT AATAATAACT ATTACCATTA TTATACCAGT AGCTGTCA*TF TAM~AGTGC TrATT'FG CCAGTCACTG TTCTAAAT7C MIJACATGTA TTATACAACT GCCATATAAC TGCCATATGA GGGATGTACC CTCATTGTCA CCA'II1ACC GATGAGAAAA CTGGCATAAA ACGTI1AAGT AAC=GTCCA AG7TACAGAG CTrAGTGAAG CCACAATGT7 GCTCAA'TrG CTCTCAAACT TCAAAGGGAT GGGAAGGACA CCTAAGTCAT AGAGTC'=A AGAATCAGAG CTAGAAGGAA TCTAGATGT TATCTAGTCA GCCTCCTCCC ATrACAGTCC AAGAGAAGAT GGCCCTGAGT TACTrGTAGC TA7m=GCA TGTGAATTGC AAGTGAATAT ACAT7CTACT GAAGATAAAA GATATrAAA GATATCGCTG GATATAGGAA CAGTGGT=f AAATCTCTAG GC'IMAAC= TrCTCAGAAC AAGAAATCCT T=rGG=F~ AATCTATATG CACATCTGTA TI1CTCAA 'VrATCGGGTA GTAAAATATA AC'TrrMC TGTAATAM T'1rAACT7A ATGAGTGTTC WO 00/09525 PCT/US99/1 7712 kzpl-109 125 CTCATAATAG AAAAG TTGG AAACCATTGC TATGGGTATA TACF=CTAA AGGGATAGTA A'TTrC1rCTAG AATAT7CAFT TAATGCTCCA GAAGTAAPTrA GCACAATrGT GCAAGTCTGT GCATCATCAA CTATACAT7C TGCCTGTITA CTCCAAATCC ACATGAAACT GATFATACAG TCAAAGGCGA GCCCAGTGGA GAGGCA I= TGGAGACTTC CTGGTACATT GAGACAGGGT CGGCCAGTCT GCG FrAGGGT CTrGGTCAAA ACTGCAMTC TGAAACTAAA CTCAGATTGC TI17CF1]AA GGGGTCAGAA CTGATTCAAA TCTACATTT TAAAAGCCTr AGATGTGGGG C1TICCTAT TCCCAGTCTC CGCTAT-rGGT cITtrGTGAAT CCACAGGCAA 717GGCCACA TCCTrGACTC TCTCTFATAT TAAGAA77AA ACAGCTAAGT TCATGCAGAG GAAATATAAC AAAGGAGGGA CTICCTACA AGATC1TGA AAAATGGAAC A TrGCATAA GTCATATFrA GCCAGAACTG TTGTI=ATA =IrCC'TrC TGAATACTr GT7ACACCTC CTCCCAGCCA ACCCCCCCCC TCCCTGACCC CAACTAGTCA GAGACCAAAG CC~rCACAAT GGTrACACT TGAACCITCC TGGCCCCACC CTCATCATCA CGCCTGAATA ATTACA'FrCA CTGACTGGTC TCCCCTGCTT CCGMTATCT CCACTCCTAA ACCCTCTGAC ACCTrAATCT TCCCAGAATA CCATTGTGAT CCTGrrFCCAC TCT'rGCTCAA GTTICCCAG AAACTAGAGT ACAAAC'TJA TAAG='~AG AGTFGAAAGC CACTCTATcCT =ITCATC CCCAGGTCTC TGCCAAGGCA GTATAACCTG TCCAACATCT CTAACTTCAA TACC'IrcTC TTAGATACTA GACTCTCCTC CTGGTrITCTA ATTAAACCTG ATCTAGGATC TAATITGCC TCTGAATrCT GTFGCCCTF GCCAAGTGAT CTcrrCc7CC TCTGAGCCGC AGCATCTrCTG AGCTrGCACA CTTAGCATAG CCATAGCACA CACAGCCTrA GCTfGCAGTr CAGGGTGTI7 ACCT'rCCCTC CCCTFCCAGA TGCTGGATCC CCAGGGATAG GAACT~TGCC CTFIATGTGTC CATAGCCCCT GGTAGTATGT CT7GCAGTCG TACATI=CA GCAAATGTI7f AATrGG FTAA TTGAAGACAA CTGTCCCATG CcTrAAGCCT CTCTT=GC TAAACATGCC TGTGTCCIT GTCA FTGAAC AACTrATIG ATCTATITC TTCCTGACAT AGGGGTCAGT TCCGAGGATG CTGAAATCAA GAGACATAGC TrATrCTCTC AAAAT7GCT TCAAGAGTGA =1~GTTGTG AA7TGAGAAC TGGCTGCCTA CTFFGGACT ACCCACTTCA GCAAGAGTGT TrGAAACCAA ATCTAT-rCTA AGTAATITT TA-I-CCC1T TCTCTATGGC ATTAGACACA CAGGCITIT AAACTACCTT TCGT-TATCTA TTAAACAGAC ATTCAGTAAC TCTATAGACA CTGTCTAGCT ATATGAACTTr AGACAAACTA ATATCTCTGA GC~rCAG'FI CTTAAAAMTr AAAATGAGGA CAATACCATC TATGGCCGGG GATrAAATGC TATGAGGAAT GTAAACCAGA TGTCAGGTAC CATCTCTCTA AAATCCAGAT AAAATGAATT AAAAATACTG GCCGCAAACC CTCTCTAAGA GTrCTCAAAA TTCTCAGAGA GCTTAATIT CATGCTCACC ATAGCACCGA T7=CTA AATA=IFGT 'FFCTACCAAA ATAT=TGTC CCAA=IFGC C'FTFATGGC TATrrC'FCA TATCCA=rr CCCAAACTAA AGAAGCAGCC CCTCAC=T AAACTCCTCC 'FrCAAAGCAA CCTAAATACA GGTCTGGGTT TGTATrCCTA GTGGGATGTT ACAGAGGTTA GTGTGATGCA GAGGAGGAGT CATGCTG'T AAATCCATAC TAGTCCCCAG AGGCCAGGCT GCTTCTGCCA CCCCTACCCC TCCCGCCACA GAGCTCTrCA GC=CTCACA 'I1rCTAGTTC TTCTCTCTCT ACFICAITA CCTrCTCTCT 'FITITIr CTrCTCATGT GCTCACGGGA GCAGAGAAAA TTAACTCCTC TAAGT1TCT TAACACAGAG TGCCTTAA17 ACATA'ITACT ATTGITr7GAG TTCCTGCCAA CACTACGTCT GTAGGGTCAC ACCTGCTATA TI'AGAGGCTI' ATCAAAAAAA GATAGC1=C TCCTAAAAAG GGATI7GGAT GCCT7ACTAAG ATAACTGGAT GCCAAGATAA GTTAACCTA ACAAACI=A T[ATTA'FrAT TATTAT7ATr ATTAGAGATA GGTACTATr CTGTCACCCA GACTGCAGTG CAGGGATGCA ATAATAGCTC ACTGCAGCCT CAAAGTCCTG AGTrCATGCA ATCCICTGC TrCAGCTCCC TGAGTAGCTA GGACTACAGG CATATGCTAC TCTGCCCAGC TACTITAAA AAAATAA'ITA GGGATGGGGT =TGTFGTAT TGCCCAGGCT CGTCTCAAAC 17CTGGTITC AAGCAATCCT CCTGCCTITT ACCTCCCTAA TrGTrGGAGT TACAGGCATG AGCCACAGCA CTCAACCAAG AM~AAAAAC =h1AAAAGA AATCACA'ITA CTTACTGTrA TCATCATrAT GGT7ACTACC AGTGTTAAAA CAATTGGTAT TGAAAACACC ACTACCAGAT CAAGCTCAA ACCAAGATGT CAAGTAAATA TrITGTCAG ACCTCTGAGC CCAAGCCTGC AGGTATACAC CCAGATGGCC TGAAGCAAGT GAAGAATCAC AAAAGAACTG AAAATGGCCG GTFTCCTGCCT TAACTGATGA CA1TCCACCA ITGTGATITG T7CC1TGCCCC ACCTrGACTG AGGGAT7AAC CTTGTGAAAT TCCTCCCCT GGCTCAGAAG CTCCCCGACT GAGTACCTTG TGACCCCCAC CCCTGCCCAC AAGTGAAAAA CCCC=rrGA CTGTAAITI CCACTACCCA CCCAAATCCr ATAAAACAGC CTCACCCCTA TCTCCMTCG CTGACTCTCT T17CAGACTC AACCTrGCCTG CACCTAGGTG ATTCAAAAGC 'I1rAT7GCTC ACACAAAGCC TGTTTGGTGG TCTCTrCACA CAGACCATGT GACAMrGGT GCCGTAACTC AGATCGGGGA ACCTCCCTG GGAGATCAGT CCCCTGTCAT CCTGCTCTP GCTCCATGAG AAAGATCCAC CTATGACCTC TGGTCCTCAG ACCAACCAGC CCAAGGAACA TCTCACCAAT 'ITrAAATrGG GTAAGTGGCC TCITMTACT CTCTTCTCCA GCCTCTCTCA CTATCCCTCA ACATCI IICT CCTT7CAATC rTGGCACCAC GCTFTCAATCT CTCCCT]CCC TTAA717CAG 'FFCCTIC =TCTGGTAG AGACAGAGGA AACGTGTTCT ATCTGTGAAC CCAAAACTCC AGCACTGGTC ATGGACT7GG AAAGACAGTC TTCCCT-rGAT GITAATCAC TGCAGGGATG CCTGCCTGAT TATrCACCCA CA'TTCAGAG CTGTCTGATC ACTGCAGGGA CGCCTGCCTG GATCCTrCAC CTAGTGGCA AGTACCACTT TGCCTGGGTG GCAAGCACCA CCTCTCCTGG GGGGCAAGCA CCACCTCTCC TGGGGGGCAA GTACCCCCCA ACCCCTTCTC TCCATGTCTC CACCCTCTCT TCTCTGGGCT TGCCTCCTTC ACTATGGGCC ACCTrCCACC CTCCATI1CCT CCCTPTCTC CCT-7AGCCTG TGTTCTCAAG AAC1I7AAAAC CTCTTCAACT CACGTCTGAC CTAAAACCTA AATGCCTTAC 1TCCTGC AATACCGCTr GACCCCAATA CAAACTCAAC AATGGU7CCA AATAGCCTGA AAACGGCACT TTCAATn7CT CCATCCCACA AGATCTAAAT AATrC'ITGTC GTAAAATGGA CAAATGGTCT GAGGTGCCTG ACATCTGGGC ATrCr=rAC ACGTCGGTCC CTCCCTAGTC TCTGTrCCCA ATGCAACTCA TCCCAAATCC TCC17=I~C CCTCCTGCCT GTCCCCTCAG TCCCAACCCC AAGTGTCGCT GAGTC1TCC AATC17CC1 T-rCTACTGAC CCATCTGACC TCTCCCCTCT TCCCCAGACT GCTCCTCCTC AGGTCGCTCC CCGCCAGGCT GAATCAGGCr CCAA~rCTrC CTCAGCGTCC GCTCCTCCAC CCTATAATCC flCTATCACC TCCCCTCCTC ACACCTGGTC CAGCTACAG ITJCATTCTG TGACTAGCCC TCCCCCACCT GCCCAACAAT 7rCCTC7rAA AGAGGTGGCT GGAGCTAAAG GCATAGTCAA GGTTAATGCT CCTri=CT-r TATCCAACCT CTCCCATCTC AGTTAGTATT TAGGCTITI T7CATCAAAT ATGAATACCT AGCCCACTCC ATGGCTCAT7 TGGCAGCAAC TCCTAGACAT 'IMACAGCCT TGGACCCAGA GGGGCCAGAA GGTCATCTTA TrCTCAATAT GCATTA T ACCCAATCCA CTCCCAACAT TAGAAAAAGC TCCAAAAG F7 AGACTCCGGC CCTCAAACCC CACAACAGGA CTrrAATTAAC CTTGCCTTCA AAGCGTACAA TAATAGAGTA GAGGCAGCCA AGTAGCAACA TATTCTGAG TrGCAATrCC 'rTGCCTCCAC TGTGAGAGAA ACCCCAGCCA CATCTCCAGT ACACAAGAAC FrCAAAATGC CTAAGCCACA GTGGTCAAGC ATrTCCTACAG GACCTCCTCC ATCAGGATCT TGCT7CAAGT GCCAGAAATC TGGCCACTGG GCCAAGGAAT GCCCTCAGCC TGGGATTCCT CCTAAGCCAT GTTCCATCTG TGTGGGACCC CACTGGAAAT CGGACTGTCC AACTTGCCCA GCACCCACTC CCAGAGCCCC TGGAACTCTG GCCCAAGGCT CTCTGACTGA CTCCICCCA GATCI=~G GCTTAGTGGC TGAAGACTGA TGCTGCCTGA TCGCCTCAGA AGCCTCCTGG ACCATCACAG ATGCTI'GG TAACTCT7AC AGTGGAGGGT AAGTCCGTCC CCTTCTrAAT CAATGCAGAG GCTACCCACT CCACAT[ACC TTCTCrrCAA GGTCCTGTI' CCC'GTCT7 CATAAATGTF GTGGGTATTG ATGGCCAGGC TTCTAAACCC CTTAAAACTC CCCAACTCTG GTGCCGAM~ AAACAACATT CTI=ATACA CT7CTITTA GTTATCCCCA CCTGCCCAGT TCCCTTA'ITA GGCTGAGACA 'FITAACCAA ATATrGCT TCCCTGACTA 'CCTGGACT ACAGCCACAT CTCATTGCTG CCC~r=~CC CAACCCAAAA GTGGCAACTC CTTGCCACT TCCTCTCATA WO 00/09525 PCT/US99/1 7712 EPI-109 126 TCCCCCTACC TTAACCCACA GGTATGGGAC ACCTCTACTC CCTCCCTGGC AACAAATCAC ACCCrCATIA CTATCCCATT AAAACCTAAT CACCCTrACC TGGGTCAACG CCAGTATCCC ATCCCACAAC AGGCTT7AAA GGGAYX'AAAG CCTGTTATCA CTrGCCTG~r ACAACATGTC CITIAAAGC CTGTAAACTC TC=TACAAT TCCCCCA Trr TACCTGTCCA AAAACTGGAC ATGCCTTACA GGTAGTTCA GGATCTGTGC =TATCAACC AAATrGTCM GCCTATCCAC GCCATGGTGC CAAACCCATA TACTCTCCTA TCCTCAATAC CTCCCTCCAA AACCCCTCCA TAACCCT7AT TCTGTFCTGG ATCTCAAAAC ATGCTT TACTATTCAT T7GCACCCT CATCCCAGCC TCTCTTCACT TTCACT7GGA CTGACCCTGA CACCCATCAG CCTCAGCAAC TTACCTGGGC TGTACTGCCG CAAGGCTICA TGGACAGCCC CCA'FLACCTC AGTCAACCCA AAT7CfCT TCATCCATTA CCTATCCAGG CATAGT7CT CATGAAAACA CACGTGCTCT CCCTGCTGAT CATGTCCAGC TAATCTCCCC AACCCCAGGA CTGGCAAATT GA=IIACTC ACATGCCCCA AATCAGGACA CTAAAGTACC TCTGGTCTG GGTAGACACT 'FrCACTGGAT AGGTAGATGC =I!CCCACA GGGCCTAAGA AGGCCACCGT GGTCA'ITCT TCCCI1X1rGT CAGACATAAT TCM~GG IT GGC=TCCCA CCTCTATACA GTC1TGATAAT GGACAAGCCT F7ACTAGTCA AAGCACGCAA GCAGTICTC AGGCTC=GG TATTCAGTGA AACCTrCATA CCCCrrACCG TCCTCAATCC 17AGGAAAGG TAGAACTGAT TAATGGTCTr TTAAAAACAC ACCTCACCAA GCTCAGCCTC CAACTTAAAA AGGACTGGAC AGTACITA CCA=TGCCA TTCTCAGAAT TCGGGCCTGT CCTCGAAATG CTACAAGGTA CAGCCCA'ITr AAGAT7CrGT ATGGACGCTC CITITTFA GGCCCCAGTC TCATTCCAGA CACCAGCCCA A=~GAACTG TGCCCCAAAA ACITGTCATC CCTACAATCT TCTGTCTAGT CATACTCCTA F7CACCATTC TCAACTA=T GTAAATGCCC TGCCCTTf TACAGTGCTG ATTTATA=T TTCCTCCAAA CCATCATAAC TGATATCTCC TGG=FTACC TCAAACCGCC ACCCTrAAGT CTCTCTAAA GTGGATAGAA GATCTrCAGT GACAAGGTAC ACTCCAATAC TITCACCCTA ATAAAGCCCT ATrC=1ACT TT7ATATTCA CTCTrATTCT TGTF7CCCATT CTATGCCAC TCTCTACCTC TCCCCAGCTA TCTCCACCAC ACTATCAATC TCACTCACTC TCTCCTAGCC AMTrAATC CT~r=AAC AAACAAT7GC TGGC=rACA ATCTC'= CCTCCAAAAT CACCGAGTCC TCAAInrACI' CACTGCTAAA. AAAGGGGACT CTGCATATT TTAAATGAAG AGTGTTGTrr T7ACCTAAAT CAATCTGGCC TGGTATATGA CAACATAAAA AAAACTCAAG GATAGAGCCA AAAACCTrGC CAACCAAGCA AGTAATT1ATG CTGAACCCCC TTGGGCACTC TAATTAGATG TCCTGGG'ITC TCCCGA'TrCT TAATCCTIA ATACCTGTI' TrCTCC'FrCT =TATGCAGA CCTTGTGTCT TCCNITTrAGT 7TCTCAATTC ATACAAAACC GTATCCAGGC CATCACCAAT CATTCTATAC GACAAATGTr YrAAGGGAGG AGACCACCCC TCATAITFGTC TTATGCCCAA TT17CTGCCTC CAAAGAAAGA AGTAAAAATG AAAAGGCAGA AATGAAATCC ACAGGCAGAC AGCCTGATGC CACACCCTGG GCCTGGTGGT TAAGATCAAC CCCTGACCTA ATCAGTTATG T7ATCTATAG A'FrACAGACA TGTATGGAA AAGCACTGTG AAAATCCCTG T=TGTTCTG 11'CCTCTAAT TACCAGTACA CGCAGCCCCT AGTCATGTAC CCCCTGC= G CTCCCCCTGC T7GCTCAATC AGTCATGACC CTCTCACGCA GACCCCCTTA GAGT7GTAAG CCCTrAAGAG GAAAAGGAAT TGTTCACTCG GAGAGCTCGG TTMIGAGAC ATGAGTC1TG CCAATGCTCC CAGCTGAATA AAGCC=TCC TTF=AACT CAGTGTCTGA GGGGTITGT CTGTGTCTTG TCCTGCTACA GTTTCATCTA ACAACCCCAT AATATCACCC CTI7ACCACAA AATCUrCCT7 CAGCTTAATC TCTCCCACTC TAGGTTCTCA CGCCACCCCT AATCCTGCTC GAAGCAGCCC TGAGAAACAT CGCCCGTrAT CTCTCCACAC CACCCCCAAA AAITICACT GCCCCAACAC TTACCACTA TrCGTITA 1I11CTAT TAATATAAGA AGATAGAAAT GTCAGGCCTC TGAGCCCAAG CCTGCACGTA TACATCCACA TGGCCTGAAG CAAGTGAAGA ATCACAAAAG AAGTGAAAAT GGCTGGTTCC TGCCTTAACT GATGATA'ITC CACCAT7GTG AMTGTrCCT GCGCCACCTr GACTGAGGGA T-rAACCT'rGT GAAATTCC11T CCCCTGGCTC AGAAGCTCCC CCACTGAGCA CCTTGTGACC CCCACCCCTA CCCACAAGTG AAAAACCCCC 7TFGACTGTA A=I~CCACT ACCCACCCAA ATCCTATAAA ACAGCCCCAC CCCATCTCCC TTTGCTGACT CTA'TTGG ACTCAGCCCA CCTGCACCCA GGTGATTCAA. AAGCTTCATr GCTCACACAA AGCCTGITTG GTGGTCTCfl CACACCGACA CGCGTGATAA. 'TA FrATA~r ACF=~AACT AAAACCCT= CAGAGTCTCG CAGGGAAGGC TGTATATATC TCATAAAATG T7GGGGCCCA CTGGATCAGA CAAGGCCACA AAGGCCAAAG GGAAGTAAAG ATCTCATrAT TTCT7CCTAAT AATrT7CCCTG TCC=rGTCA TAAATGGTGG GTAGGCTGFIT ATGGTGATGG CAGATITCT 17CCATAAAA TGTCCATAAT AGGACATFJ7G AACAGAAGGG AAAAATCAAA T7GC7GAAGT TGAAAGAGGG CAATGCAAAG AA=T1GGAG AAAGAACTGT ACAGAGAAGT CAACTGGCAG ATGGGAGGAA GITr1AAGGGG AAAAATATAG ATGTCTAAAG AATACA'IMA TTCA1TfCC ACAGTGCAAT TTGGACAAGA AGCCTCTIC 'FTGCTrT= CTATrCTCAT TAAATCA7FA GAGCTCAAGC AATCCTTCTG CCTCAGC'FfC CCGACTAGCT AGGACTACAG GTATGTGCTA CTATGCCCAG CTAATT= AAAAATI'AGA 'F=AA Tr7G GTGAACTATr TCTGTAGGAA ACTACAATAA TACAGCCCAG GCACAF7GAT =TGGGTGAA CAAATCAGAA GGAATGAATA ATrCTGTG F~ CCTGGGACTC TGACAATTC ATGAAC17GG TACTCTGAGT AAAGCATAGG AGGAG'rrA'Fr TCATAAAATG TGGAGCACAA TCATGTGACA AAGATAATGG GATCCCCATT TCATAAATAA ATCTGAAG'rr CAGAGAGAGT AACAACTGGC CAGGGTCACA TCACGGAGAC AGAGGCAGGG 7TCCCACTGA TGCCTCTGAC TCCCTGTCCC AGGCC=~CC TCCTCCCGCA AGCAGAAGTG CAGGGGGCAG AGCTGACCCT GTGCAGTGAA AATCTGAGGG CTGAGflCCT ATTGGAACAC AAGTGAAAGA CTCCTGGCT TCTAATCTCA GGATAAGGAC TCAGAGCTCC ATCrTr1CCA GCCTI7AGGAT AAGAACCAGA ATCTI'ACACC ATGAAAGCAT GAAAGGTAAG AMGAGTGA GGAAAAAAAA AAAAAAAGTC TGTGTITCAG A FTCAGY17CA CAAAGCAGTJ? TCATAC=AA GGTACCATCA CAATAACCCT GTGGGGTAAG CAAGGCAAAT TrCA'rrCTrG TITATGGGC ATAGGAAGTA AGTCTCAGGG AGGTTAAGAC CAAGGTITCT GGAGAATIT ATATI'ATGAA TCTrGATTrA TGGGATrACT A'ITATGTAAT TCCTAAGATC ATATAGGAAT CCTAGAGC= GAATATAGAA =T1AT=lT AAATCTATAT ACATCATAAT TACAAGGAGT AGTGTCCATr TGGGTTCCT7 GGCCCTGATG TGTTAGTGGA ATAAACATI1 T7GTCAGGGT TGCCATGTGT GTCTGTGCAC GTGTGCACTG TACACCTCCA GGGGATGTAC CCTAAACCAC ATGAATGTGA 'IMGCACATC CAAGAMIAC AGTGTACTAT AGGGAGAATC ITFGCAACA GCTIIGCTA TAATACAGAA TCTGAGATGT CTFGAGAAA GAAAAGTGTA ATCATrACCA AAAAATTAT7 CTCATAATGT GTGCAAAr GTATGAAATC TATATrGGCC ATGGGACAAG GAGGTAT17C CAGCTAGCT1T CTGAAAGGGC TCTrATTCTCT CATAAGAATr CAGC7T7GA CA'FrAGGTGA TATCTGCCCA GGTCATCAGA TGCCATAGAG AAAGAGGGTT TGCTGAAACTr TATATCAGCA GTGCACTGTA TGCT=TF GAMTAM~G AACATrCATT TA'TGAGTGT CAAGTAATGC ACTAGATACT CCAGGGATCT GACACAAACT CTGCCCTGAA. GGAGCATGTA ATCTCACTGG GGAGAAAACA AAACATATGA TAATIrCAAA ATAACAAACT AGGCAAACTA GTTAACACTr AAAAAGCAGG CIAITrCAA ATGCAAAATT GCATGTFACA GGGTAACCTT TCAGTAAGAA GCCAGGAAGA GGAGCTCATC ATGGG'TGGA 'TrAGTAAAGG ACTAGTTATA AAAGAAGTGG TGGGGT7GAG GGAGGCCTGA GATGAAA'IM AAAGAATATG TAGAATCTAG GTAAGTGGAT AAAAGGTCTG GGGGCAGGGG AAAGGAGAGC A'TrCA'ITGT GAATCAAGGA KITTC-CCAC CTGTITAAC TCTCCATAT GACATCAAAG AGATGTCACT TGCAGCTAGC A'T1CAGTGA TGT==TA CTAATAATAT CGTGATAAAA GAAACATrGA CTATAAGAAA TAGGAATGGG TCTCATAAAA GGAAACAGCA AAACCCCCAA ACTAAAAAAC AGCGCAGGCT A'TTrCTCTCT TCTCTC=~1 TG=IGGCAC TCATGAGATG CTAGGTGTGG AAGTCAGCCA ACTGAAAAAG AGAGGTGGCT GAAGAAGGTG GGGAGGCTGA AGCCAGT[AA ATAGGATGGT CCAA7I1CACA GACGGCGAGG CTACAGTGCA AATAGGACTC TTTCAACTTG AGCAGGACCC WO 00/09525 PCT/US99/17712 EPI-109 127 CATTACTTCA CTGGAGTTAG AAAGAAAGGA GAGCGTAGAC TTITGAACT TTCTATAAGA GTGTACCTCC AcAGTATACA GAAGACGACG TGAAAMTrGA TCTGCAAGAA AACTGAGTCC ATAT1'CACAT ATGTATCAAA 'I=GCACTC A'IMAGAAGT GTCTGTCATC AAGTACAGCA CTGAATFGAA ACTGAAAACA AGAGTCAAGA AAGAGCAAAG TCAGCCATCT TITATA'ITCCA CATGAATCCT FCC='~AT GGTCITIT GTTFCTCCTC AGAAAAGACA AAAAGCTGAG CTGTATAAAC ACCTGTGGGC TGGGGGTGA GGGATAAATG AGGGGCGAAA TGGAAGCTGA AGGAACTGTTr GGTCAGGTAG AAATC'ICCC AGATGCACTG AAGGAAACAC ACTrCATGTT TGACGTAGGA GGTGCCACCA CACAAAACGT TTCATGGAAG GA 1TAAAGG ATCTCATGAT =fIAGTATF CCAAGAA F1T TCTTCACCA AGGGCGAT AATATGGGTC ATTCATACTG AAAGAAAAAC AAAAGATAAT AAGAGMrAA AAA~rGCAAA ACTrGGAGTG 'FrAGTAGTAA AGGTAAATAT TCA FrAGAGA TGAGAAGAGG AGCAAGGAAA TGCTTCAGC TGGAAATCTC AGACAAGAGG CCAGGCTFA GGAACCTCTG AAGATGAACA AATGTAAGCA AACCCTAGTA GCAGCACTTC TCAGA'ITC ATGTGC=AC CACTCAGAGA TGGTGTrAAA ATGCAGACTC TGATTCAGTA GGTCTGAGTG GAGCCTGAGA T-fCrGCACCC CTAACAAGCT CI=AGTGAT GCTTATGCCA CTGGCGCACA GACCCCAC'IT GGAGAAATIT TITGTGGTGCA TACGGTCT= GTC7CCAGAT CTAATGAGTC TGAAGGACAG TGTAGA117GA TT=AAAT YrATG'IMAT 'ITrAAMrAA 717rAATI-AA 'TrAAT7r TATATIT TGAGATGGAG TCTCACT~rG 'T7GCCCAGTC CGGAGTGCAG TGGCACGGAG GCAGCTCATG CAACCACGGC CTCCTGGGTT CAAGCGATrC T7CCGCCTCA ACflCCTGAG TAGCTGGGAA TACAGGCACG TGCCAGCACA CCCAGCTAAT T=rGTA'rrr TTAGTAGAGA TGGGGTFF7CA CCACATTGGC CAAGCTAATC TCAAACTCCT GACCTCATGA TCCACCTGCC ACGGCCTCCG AAAGTGCTGG GATTACAGGC GTGAGCCACC GAGCCCAGCT GTAGATTGAT ITIGAGCAGT GGAAAGTCAA GGAAT7AGAA GGCATG=~A AATGGAAAGT GAAATFTGGAG AAAA'1AAA CTCATGAAAT AGTGGTGGTT ATAAACTCGT GATAAATTAT ATCCTGGGAT ATAA ITAAT GAGATGGTAA CACATI17AGT T[AAAGAAAT AAGTGACACT TTflTGTGT GACACAACTG TCTTATTCYT GGAAAGGACA AGGAGAGAAT GAAATATGGT ATGTCTTCAC AGCACCTFC AAAGGGAGAA CCAGA'ITCTG AGGAGCTGGT CTCATGATGA ACTGTCAGGG TAAACCACAG TT1CAGCAGCT GCAAATGTGC 7rGCCAAAAT AGAGACAAAA AAATGTTCT GAAAACAAAA T-17CACATAT GCCCTCCTCT GAGGTFGGCA TCATAT=TC CTGTGTATCT TGGGTGTAGC TTCTATCCTG CCAGAA'I=A GACAGTAGAA ACCAAATGAG GTGATAAACA GAGTCATIT GCAGAAGAGT CAAAATAACC CAGCAAGAAA TGAAACCACA AATGCCCAAG GAGTCATCA TPTCACCATFC AAAAGCTAAT AGAAATGAAC ACAAACTACT ATGAAAAT7C ACCCAAGAAC TI7AAAAAAAA AAAAAAAGGC TCATGGTGTI' TAGTGTGATA GTATTCA1T TACC'ITGAC TrT'TCTAAA AACACACCAT AC FTCTACCC CACCCT7CCT CAGTGCCGTC ACACAATGGT 'FrCAGTGTGA AAAAAAAAAC CACGTTACTG GAAAAGGAGG GTGCCTGGGA CT.FGCCACTC TAAGCTGGTA GTCAAGGGTC 'FrGAGTTCTA AAAGCATACG CGTTAAGAGC ATGATTCCTG GATCCAAATG AGTATGGATC TCAGCATTGC CATATrGT GACCTCAGGC TATITAMF CTCTGTGCCT GM=C'TAT CAGTAATGAA GATGTrCATA GACCCTTCTC CCACAGAC= AAAGGCATAT TrCATGA'ITr AAGACATGTA AACCATI'CAT AACAGTATAC AACATGGAAT TAATATrTGA TAAAGG'ITA TGAflKI1TGT AACTAACTCT GTCACTTGCT CAAGGCCTAT AGAAAACTT1A C7rAAITrAGT TCAACTACAA AAAGAGTI7G AATGTGATAT CCACCAAGAT CATATTCAGA CCTAGAATrC TGTGA'rCTlr ATGAATrAAT ACAGCC17~GG TCAATAAATG AGAGCTGGGC AAATAA'rrCT TCT1TGCTAG GCCT1T7CTAG ACCATCTGGT GAAGCAT7CA AGACTATGT TAT7GGGGCC AGCCTrCCTT TCCAACTTCA ACTCCACAAC TCCTCAATAA GCCATGGGCT CAAGAAAGTT CTGCTCAGTG GCCCCTGAAA AATGC1TCA TAGTCTCACT ACCATACCAC TGCTrACACA AI7CCTrCC TACAGACTGC =C=r~rCC TGCTT=CTC CATATACCTA AATCCTATCT AUrCITCATA AGCAACCT7C I17ATAACAT TPTCTATAAC CACCAAGCCA AATGACC'= TCCTrCTTAA ATATAGCACC CATTGGCCAT TACCATGCTC TGCCTTGTAT =F~CTGATT Tirr=rC TATATTCCTG TCTrAACTCC CCAGCTAGGT AATAATI=C CTGAAATCAG GGACCAGGCT GACTCCTCIT GCTGTCTCAA GAAAGCTAG CAGMTCCAA CACAAAAATG TFCAATAAAC AACTATTAAT TGACTGAT7A TAAAAAATCA GTGAACCATr AAACTTAATA TAGCAA'ITG C'FAGCATGG TAATrAGCTT 'Tr7GCTAATA 117C=CCAGC CAGTCTCTCC TCCTGTGCCT CAAGGACATC TI'AAAAAAAA AAAATCTAGT TGATCTGCTT CCATCTAGTG GCAATrAAAA CAGGTGGflC CGGTAGCCAG AAAACAGCTC TGGGTAGATT GTGCCAGAAA ATAC1TCAC TCAGTAGGTG CGAG'TrFGAA AGAAATCTTC ACATCTGTGG GTTTCCTGCC ACAGACATAG GGAGACCAGC CCAGAGAAAG AAGCCT=CC TCACTAGACT CCAMFIGCAC TAGTAAAGAG AAGACAGAGT AAT7AAAAAG AATAAAAAGA ACCTCCACTG ATCGTACATC CTCATCCAGT TACCCCTGCC CCACTFCTCC TrCACAGCCA AACATIIAA AAGAGATGAC TGC17GTTCT GTCTCTACTI' TCTCATCCTC AGTAATGCTC AATGCTGGC CGTCTGACCT CTGTCTGAT GTCTGCACTG CAAATAGTCT CCCCACTGAC ACCCUTGFFG CATCCAGGGG ATACTIACTG G TTCCTrGG CAATGTrGA AACCGTTCCC CTrCI=GT TTCcYI'GGCA TrCA17ACCC CACACTC1T CTCCT=rCC ITCTCCCTGC CTGGCAACAT C'F=CAM~ CTC1TCCCT TAGGTGACTT ATrAGATAAT GATGTrCCTC TGGCTCCCAT ACTCTCTCCC AGGTCCTCT7 CCAT7CTTAA AGCACTCACA CCCTCCCTGG ATGATAGTAC CCACTCCTGA GATGGCAGT[ ACCTCCTGAA ATGTGAGGGA CCCAAATCCA C2FCTCCTGC CATAGCCTCT GTGC1TGGA TAGGTCCAAT GAGCCACAGT GAATGATGTG CATACACCCA AAGCTCAGTA CAAAACTGAA CCCATGATCT TrACCTCCAA AACCTCTCAT TCT1TATGT TCCCTTCTCA GAAGTAAACA GGACTACCAT CCGCCAGTIT7 CCAGGTGAGA AAGATGATAA TITGATT= CTCTCTCACT TITAGCCAAT TAACAGACAC AT7CAG~rAA TATCACCTCC TCTrA TTCA TGAACCCATT] CTTACTACTA GTrCCCTAGA CAGGCGCCAT CGGTITAAT CTAATAACTG CAAATGCCTC CAAAACAAGT CT=I1GAAT CCAGGCTCAC CTGTCTCCCA CACTTGCCAT ACTGCTCTGC AGGGTGACCT TATAAGATGC CAGAGGTAAG GCTACTCACT G ITAAACCC CITAGTGAT ATCCCAAAAG ACCTCAAGAT AAAGCCCATA TCACATGGCT TATACATTAG I1ATGATCT GGCT~CTGGT GCCrCA'I= TCCCCACTIT7 7rCCTGCA TrCTAAGCAA TGGCCCATAC TAAGTGTG A~rGG1TAGGA TGGTrGCCCA AACCAGCATC CAATCCCTFC AGAAATCATC TCACTTCATT TCTAGCATI17 TAAAGGAAGC TCAGTTGTCC AGCTGGGTAC TGAATATGTC ACCAAAGTCC TCC FICATA G'TTrArTA CTTAAACTCT CC=CCTAAA ATTCCAGAGC AAGTCACTAA ACCCTAGATA CTGAGAAATA FTrCCATC TTCAITCTG CCAGGTGGGC CATCAACT= CACATGTCTG CATCTCCTCC CACTGTGCTA TITrCTCCAGT AGAAGAAAF7 TGAGCITCAA GACCAAACTG AAAAATAC'I GCCTCCTrGG GGAAGCTGTA GGTAGAATC ATGCTCCCTA TC1TCCCAC ATMrCTGAAG GACAATGCCT G FrAGAGCAA TTGAATGCAA ATAGTCAAT7 GAATAAGCAT 'ITATrCAT7r CTCAATAAGT GCTTGT[CAA 'FrGAATAT1Tr CTTAAATAAT ATATI1AAGA ACAAGAAGAA CACACCACAA TGTI=AAC CCTCAGAAAA AATTCTGAGG TAATCAGAAA AATCTCCCTr TACATAAACT GCCCTI=CT AATAGGGATT ACTTGTTCGT TCATTCA'FrC A FTCAGCTCC ACTAGCACCA AAAAGCACAG CTCTGAAAGG AAGCTAGTAG A'TrATCACC TrATCTGGTC AT1TGGATGA GGACCCCAGG TAAATAAACT ACTATGGGGT TAATGTGTCT AGCTAGAGCA GGAAGTAACT TAAGGAAGTA GAGAATGAAT CAGCAGATGT GGAAACTCCT CGCCACTAAT AAAAC'rrACC F7CTCTGGA 1TrT]TGCCT GAAAATAGAA AATAGAGAAA AGGCAflAGC AAAAATTAGA CAAITAAAG ITTTCAAGT AAGGGAGAAG GAAGACTCCC ACTCTCAAAA CTGTCTTG AAGTATATTA GGTA'F~rGT-r AGGTGGACCC TATCTGTGTC AAAGGAGAfl TGAGGAACTG GCTrAATAAA CAGTGGTAGA CACTAATACA GAACAGACAT GT7GATGCAG ATGCCTCCTG AGGTTCCA7r WO 00/09525 PCTIUS99/1 7712 EPI-109 128 CCATTCTCCG TGCTACTCAA GAAGACAGAA 25441 'FrGCTAAATF[ GCCTGGTGGC AAGACCCAAT ATGTCCAT7C AAGTGT11TAT CCCTTCCCAA TCTGCCATCT CATCCTACCT GCAGATrCTr CCC=GAGGG ACAGCTGCTA ATACTGTAAA ACTATGTGCC ATTACAGCTC ACAGCATCAT CTC1rATGAGA ATCCACAAGA GAAMICACT FrGGTCTrGT TGGTAGGAAT TGTGCAGCCT CATCTGAGTA ACTAATGTGT =F~ATCTrA CAAACACAAG GAATATCACA TGGT7CTCCT 'FrGACTGGCT GTAAGGAAAC TCAGAGCTAG ATCTGAGACC CTCTCCTACC AAGTATATAA AACI=GTGA CATACAY1T TGTGCCATAA C'rrCAACCTr GGTrCCAAAT GATT1TGTA CCCTAAGTTr AAATITGGCT TrC'fTT T1TF1TGTA CTCAATAAAA CATCAAGCTC A'Ir7A'11Tr GCGAAGAGCG AAACAACAAA G=ICCACAG CGTGGAAGGG GACCCGAGTG GGTrGCCCAA ATrTGGC=CT ==TCTACT VI=AA1rAA TT=AA7TTG CTATACTGAA CACAT=GT ACTGTTCTCA CA'ITCIr GAAAAAAGCA GAATATAAAT AAGTAGATAA CTTAAAAAAA ACTC1TGAG CAGAAAGAAT CAMGGGAG GCAATATATr TCAGTGGCTG TAAAGTGGCA TI7CTAGAATC ATCCTACCCA GGTGAAAGCC CTA=IrGCC ACCTGTAGTG TAGTGTGTAT TT1GAACAGCT AC=rCI II CTAAACTACA A 1TCMCAT CTGTrAAAGA GGCATAATAA TrGTATCATC CTCATTGGGT TGATAAAATA AAATAMTCC AAGTATTTAG TTCAGGTCCT AGCACGTAGA CAGTGITrGCA TrACrGT1T AATCCT1AA AGTA FrAAAG ACTACTATT17 GAAATCT1T CTrCTAAAAT TCAGCCTGCT GATGACCAAG TGCACT7GAG CAGGGGGAAT CAAATCTGAA YTAAT71CAG AT-rCTGG FrA GCTTCACATA AATA 1T11TT FAGGGATGA TGAACCTAAC AGCAATAGAT GAGTAAGAAT CTGTrCCTAC TGAGAGAG Fr TCATITIGAA GAAAAAGGAA CTAAGGGGGC ATGTGTrCAG ITCATGCCC TGGTCTAACC CTGTGTG'ITG GTrCTGGTGG GAAATrCTrC CAACCGAGGA AAAAACCAGT TCACAAATCT GAAGACCAGT GA=mAGAA GATGTATCTrG GACTGGAGTC TAATCTCTGA CTCTGGGTCC TGCTGATATG GTA FIT1GA GA=~GGCCT AAAACATCAT TGCCCTGGTr TCCTTATTrA CCAAACAGGG CCAATGGTAG TGACTAATCA GAAAATGATA ATGCCTGGTG CACAAAATGT GTCTAGATGA GCCCATGCAC AAGGACACAT G'IMCTGGAA CTGTF7CCTrA 'ITC='~CCT AAAAGAAAGG AGGGAAAGTC TCCATACTAA GACTACTAGG GCAGGGGACA AAGTGCTAGA GTCAGAAGAT TCATCTGAGG ACAGAAGAAT AGGGGTGAAG GCTCTAGTCA CT7CAT7GGC TACCATGCTC TAAATAGTTA CCTGTGCCCT TITCTAACT A17AGAACCC AAAAAGCCTA TAAAT7CTCT CTCTCTCTCT CTCTCTCTCT GTGTATATAT ATACATATAC ACACACACAT AGACACACAC ACACACCTAA ACACACACAT AGAGAMTAT GACTITIAC 'FTMATC=~ GTAAATGCCA TTAACTATAT 'TITGTCTTAG AM~AGCCTG GGAATGTAGC CATTAT1rCT ACCATTGCCT CCATAGGAAA AATACT=TC ATGT1TAAA GGACCAACCT ACAACTAAAA TC1TGGAAA GCAGAATCAT 77GTAAGYF7G GTGAAAATGG AAGATGflGT Tr7ATAAATG AAGAC1TIT rTrM7= TI7GAGACA GGGCCTCACT CTGTTrGTGGA GTGCAGTGGT GCTGTCATGG CTTACTGCAG CcTrGACCTC CTGGGTTCAA GTGATCCTCC CACCTCAGTC TCCTGGGTAG CTGGGACTAC ATGTGCATGC TACCATGCCT GACTAA=II TTGTATI=f GTAGAGATGT GGTTCGCCA TGTrGCCCAG GCTGGTCTG AACTCGTGGG CTCAAGTAAT CCTC~TGCCT CAGCCTCCAA AAGTGCTGGG ATTAGAGGTG ACAGCCAAGG TGCCTGGCCC ACAGATGAAG ACTATT17AAT GTrATCTrAA AGATACCCTA AG=~CCTAC CAAGCCAGTG ATCT1TGGG GCTITCTGTIT7 TC1TGTTGG CATAACrGTA ACTAGCCTAA CTGCCCGTrA TCTGTTCCT GT-17GCCCCA CACTGATTCC CACAGCAGT7 'FCAAG FrAT CGG'TTGAGA TCITGTACAG AAATGACTCC AAGGTAAAAA AMTAAAAAC AACCCCTCTA A'TTTAC CCT-FGCT7AT AAAACAGCCT TAGCCAGCTA ACCCCTCACT ACATGCAAAT GAGM~GATT CTA'ITCI= GATTrACAA. ACACrrATrA AAAGATITA GAAT-rCGGAA ATAAATAGCT TC=TATFAA GGTGACTTAC AGCCCCAAAG TCCTrAAAAT TATI1AGACA ATAGCCACCT TATCCCAGGG GGCAGTGTGT AATAACCCAC CCTGTrCTCT ATCCGTCAGT T~GCCATCA TCGCCCAAGG TAGGAAGAAA GACAGGACAA CCGGGGTCAA. GA1GAAGT CTCAATGGAA AGAATAATCA GTGGTrGGAG AAAACTGTCA TTrrCncri GCCTAATGC AGTACTI7GAT ACTTATA=~ AGTACTGTAT AGTACT-FAGT ACTGTATAAT ACTATAAGAT AGTGAGATrC AATCAGCACA GAAMTICAA TAGCAAGGGC AGAGACA'Tr TAACTGCTCA GTGCTCTCAG GUTATACATA GCTAATGAAG T7=TGCATA TCAACAATCC CCACCCCCCT CACACA= T GTCT=CTGG ATGGTUAGA AAACT7ACCT AGCGCCCACT ATrCTCAAAT 'FrAAATGAAA GATAAGATCA GAGTGGCACG CAAT7AGGGA CTGATAAATA ATAT1T1GT AATTGCCAGT GTAAATGGAC AGGGGGCAAC CI=ACATAC CATA'ITCAGT GAACAGAATA CGTACTAACT AATI1GATGG AAGGAAAATT AAAATGACAA TCAACTGAGC CCACAGAAAG GCAACACAGA GCAGTTGGTI' AGCAA FrGT TCGAGATCAT CCCTGAACTr GAAACAGGTA TATC1T-= 7M-ITITITT GAGACAGA GTCTCACTCT GTCACCAGGC TGGAGTGCAA TGGTGCGGTC TCAGCTCACT GCAACCTCCG CCTCCCGGGT TCAAGTGATr CrGTCTC AGCCTCCCGA GTAGCTGGGA 'FrACAGGTGC CCGCCACCAC GCCTfGGCTAA 'n1TGTATT 1TTAGTAGAG ACAGGG ITrC ACCATG TTGG CCAGGCTGGT =TGAACTGC TGAGCTCATG ATCCGCCCGC CTCGGCCTCC CAAAGTGCTG GGATI'ACAGG CATGAGCCAC CACACCTGGC CAAAACAGGT ATAT=TAAA AGCTGCCCAA TGTCCATGAA TGTFACAGCC TTGAATGGTr CTTCCAGGTG AGTTGGCCA AATGTGGCAC CATACACCCA AGGCCTGCTG CAGGCTAGTG GGYFrGCTCAC ACITAAAGC TGAGACACAC TCATGCCT-rA AGGTAAAGGG AGTGATAATC TGGGCAGCAG ATGTFAAC1T CTCAAGGCAG TCCTCCT7CT CTITCCTCT CCAGTGACGG ATGGTrGGAA. AGCATATATG GTGCATTrGG 'FrAGAGCTGT GGCCTFGGTG AATAGATACT TGGGAGAATA CATGGGAATT TCTCCCAGcIG TrAATGCAAT GCCCATGTGT TGGGAACCAG GTGACTCT-rG AAGAGGTCAG GTATMGGGA GCAGTGCCTT GAAACCTTAG TGGACATTAG ACCCACT17CC TAGTGGAATr GTAGCATTGA AATCCAAGGC ATGTAGGCTC T17AGAGGACA GAGATAGTGT GTCA'TITPT CAGAATTAAT TAAGAGCAGG CCAGGCGTGG TGGCTCACAC CTGTAATCCA AGCCC'=GG GAGGCCAAGG CAGGCAGATC ACGAGGTCAG GAGATCGAGA CCACTCTGGC TAACACAGTG AAACCCCGTG TCTACTAAAA ATACAAAAAA T7AGCTGGGC ATGGTGGCAC GCTCCTGTAG TCCCAGCTAC TFGGGAGGCT GAGGTGGGAG AATAGCTrGA ACCCAGAAGG CGGAGG FrGC AGTGAGCTGA AATrGCACCA CTGCACTCTA GCGTGGTGAC AGAGTGAGGC TCTGTCTCAA. AAAAAAAAAA GTATTAAAGA ATTACATAAG AGCAAAGAAC CAITAGAATA TCTCACTTAG TrGTfATCAG CCTAGCAAGC TGCCTTGAAG GTAATAGACA ITI=AAAAG 'TrATCAGAT GAAAAGCGAA AATCAGCCAA CCTGTI=AA TGAAGGTGTG TCCTGGGCTG ATrACATGT CTCCAGGGAC TGATGGCTCT AGAATGTAAA GCTrGGCATC CTGCTTGTGT TGAATCTATC ACAFI1AATr TCCTGTGGGT T7CTTT= '1rCITTC ACTTAAAGT TGTGTrC1T TCATGTGAAG rrAAACTCAC ATACC7111 T]TAATCTCCT TGCCAGCCAA ATGATAAATG CCAACCCAGA GAATGCAGTA ACCATGACTG CCACTGGAAT GAAGAGGGGG TrATAATCAC CCTCCFrAAT CATrGAGAAA CTT1GTCCA ATTrGAAAG AGAAATCAGT AAGGCACATA GCATGAGACC ACCAGCATTA 'FICCTrAGT CTATCTCATG ATAnrTGACT TflTCCTCC T7ACATCTCC CAGTAGTAGC CCAMTGATG CCA=TGACA GATGAGGAAA CTGGCATGGG AAGGCCCCTG ATGAGTCTAC AGCATAGGCA AAGACTGGAC CAGCCFGCT AGTCTAATGC CTACAGAATC TCAATGCCCA GAMTGTGGT TCATAGAGTT CCTGAAAATG CACCTAAAAA TG'ITGGCAAG AATGGTCATC GTrGTAn1TA GCTCCATGGA =TGT7CAAT GACTGGAACT CTGAAACACA GAGAAGAGCT AAAAGCCTAA TACAACTTCA GGAAAAATAA AAGCCAATGA TCTGAACTGG ATAATTCACC AGTCAAAGGA AATCATI'AAT GCTITACT TAAAGCAGrF GTGCAAAAAT AAGCACFGA TIT=ACATG CCAAGGACCT GCACTAATTr CTFCCAATG CAGTAGTTAC CACIrCCCTC TAC=CC'FrC ACGAATAAGT AAAAGGGCAT GMIIAGAGAT ACTC'=GTAA GTGTAAACTA AGTrCATFTTG GGAGCCTCTA WO 00/09525 PCT/US99/1 7712 EPI-109 129 'TGAAAATA CTGGTATAAA AAAAAATCTG TCTCCTGATA CTAACATITG AAGGAATCTA CTITITACA TA1rGGCAGA GGGTCTGAITF CTATCCTTAG TT=~CCCAT TACITGATG AACCTITCA AGGTGATITG ATCCCCACAC CCAAATATAT GATrGAGAGA AGGCTCAAGT TCCCAGGAGC TCCAGACAGA AGGTACCTGT TGGCTTGATG AAGATGAGGA GGAAATGAAC ACTAGCTAGG CCTrAAAGGG AAATGTCTCT GATAGGCCTA ATACACAGTC CTCTGCTAAA GGCCTCCCTG CCTCTCTCTG CTCATCCACT CTACTCCCTG GCCCTGGGCA CGCAGCACAC AGAGATCAGC ATIrCTGACA GCTCTGTAG ATCCTACCAT TTAAAGACI1 TrGTCATCCA TGCAGATAGT CTCAGGAGCA GACACAGGTA GCTATTCITI CACATGCTAG CTAACATGC ATMGC'rrrA ciCACCTA'FrG CCAGGCACTG TGTCAGGTGG AGGGTATACA AAGATGAACA AGACATGAT7 CTTCTCATAT ACAGATAGAT M~GGAGGCA rrAGCTTAGT GATGATTCAG GAGTATCCAT TAT~rGGGGA AGTAGGTGGT CATTAGTGAC CTITACAGG CATFTCAATG GGCTAACAGA GATGTIAGAT TGTAGTGGAA TAGAAGAATG GGTAAAAAGT AAATCAGTGA G7TCAGAMrI TAGGAGTTAA GATGGCAAGA GGTGAGAACA AAAAAAGGAA ATGATTGTCA TrAAAGGAGG AGGAAAGACC AGCCAAAGAT T7ACAGTGA GTTAAGCATA CAAAT'I1ATr TCTAGGCCAC ATATrCTTAG CAAAACAACA TGTAAATGYT TATGTATGTC TITCCTCATA TCTGCTCATC CATCAGCTCC ATCG I1AAGA 'MCAGT=f CCAGGACAAA C'ITACTCACT TTGACATATT GGACTAGGAT TTGACCAGAT TCCAGATGAT TCACAAATGG rrrCrrcr CCCAATrAAC TCAG TCCTT CTGAGCAGAT GAAGGTACAT GCAGAGGTAA AGCTGAAGCT GGCCAGGGGA TGGCTACAGT TCATGATCCC CAAATCTGGT GCTGATAGAG GCTCACACrG AATCACTTCA ATGAAAAAGA AAAAAAAAAA AAAGACAAAA CAGTATICT GAGTAGAGAC CCTCCCTTGA GCAAAGGATr TTAGCCAAA GC7GCCTGAC TACATTACT7 GTGATATTGC 'ITCCAGGCTI TA=TTG AGAATGATGG TGGGTGGTGA ATGAGAGATG AAGGCAAGGA AGCATTGAAA GCTGTGGGGA GAGGAGTAGC TACTCCAGGC TGCTGCCCTA GCTAAGGTGA CCCTCCCCrT CTGCTGGAAG TACCATGCCA TATGGCCTCT GCATCAAGGG CTCTrATGGG ATATTCTCAG AGAATCTCTG CCGTITCATC TGFI7CTGATA TCTACCCAAG CATITGAAA AACATCCCAA 'TFCACTGAAG CAAGTCCAAC TTCCGTAAAT TCCAGTAGGT GGGTrGACAG rI=ATAATT TCAATAAGGG A'TrTGATAG CACTTCTAAG AATTAAACTA CTTAAACTAA TGCATCAGGA GCATACrrGT AGAAAAG17A ACCAAAACIT CGTAAGTT7CA GATGACATrG G'IICTCCC ATATGGAGAT AAGGTTGGCA GTTAAAAATG AAAAAAAAAA AAAAACCTAC CTA=ICAA ACT7GAAAAG ATCAAGAGAT TGTG7II=G rFT]CAGTT1 G FTATTCTCC TAAAAGM~A TGCATGAGGA AAAGTAAAAG TGAT1TAAG AATAAGCCAA ATAAAACAAC CAAGAAAGAC CTCCACTACC CTGGGAAGGA AACTGGT7GG TATTAAGTAG GACACCACAT AAAACAGGTG TTATTGAGAG GAGAAGAACC AAAATGTAAC TGAGGTTCAA CAAGACATTA 7FITATGCAAT GGCAATGAGA AAAATAAAAA ACACAGTATA ACCATGCTGT AT7GCTATAA GTCATGITAC ACACTGGGAG ATGGCITCAG GGGTA'ITrGG 7FITA='~ 'rGMrGGGA GGTrrCAA AAAAAIT7AG T7AGAATAAG TCCTIGAGA AACATCACAG TAGGTTAAAC AAAGT1rAGGT TAAATrAGGC TCCTAAG'ITr GACT-rCTCAG CAAACflCTA CTGAATG~rC TGACTGTAAG CCCAGGATTG CATGACAAAA CCTCTAGTCT GAAGTFIACTC ACCTTrGACAG GTT1GGTCTG GAGATGACCA G=TCCAAAT GGTCCACAGG TGG'IT]X1rC AATCCCAGTr AAG'1GTrC CTCAGAGCA GCTGAAGGCA CACTGTGAGC TGAAGCTGAA GMTCCCAAA GGGTGAGTAC AGTCCATGGT ACCCAGCTCT GGGGCCTCCA AAGGCTCACA CTGAATCACT TCAATAGGGA AAGAAACAGT ATGGGGAAGA G17AAGAGGA ACTGACGCCT GGATrTGAAT CCTAGCCCTG CCACTTGATA ACCATGTGCC 'TT7AAACAAG GTrACTrGAA CCCTCCAACT TCAG'TrCIT CATCTATATA AGAGGAATAA TGAAATTGTG T-rAT=T1AT CAAAUrGATA TGGAAACTAA ATGTAATrCA A'ITAGCATAA GTCAAGGACC TrAGAACAAA GCCTGACrCA TCAGAAATrC TAAGTAAACA T7AGCTAGTC rrCATATTAT TATCT=CAGC A'ITATCTGTA GTGAGAATCC TFAAAGCCAA ATAGGTGTAA CTGGGAATGA CCAGCITAGT CGGGAAATAA CTATCACATC AGAGCCCCTG AGTCTACTAG AGTATTGGGA GCAAGATG Fr CAGAGAAAGA GTGGGTCTCC ATAATAAGCC 7TCTITGCAA GGAGAGAATA TAAAAGTCTA GGAAGCAITI TGACCTCAAT TCTGTC'ITCT ATrCTAGCTC AG~rCCAGAA T=VAACTCT TT7GAT=FG ACAACCCTCT CCAGAAACTG TATCTA1TIC CCTGTTCTGA TTGGTGGTAC AATAGGTAAA TFFEAAGACT GGAAATCAAA GTITCACAT TwF7AGACCCT GCCATGCCAT TTAGTAAACA GTACAACI= CATGTCTTAT TCCTCATCTG TCAAA ITAA GCCATTAT7G CTACCT7GCT CTAGAGACT7 CAAGGAAGAA TGGACTCAAG GAATCAGAAG AATTI=GTA TTGGAAACT ATATGAGATG AGATTIAGGGA GAAACATGGG AACTAAGAGA AAATGTrATC FTTrCATT GATTAAAGA GTATCTAT-FA TATATCAAGC ATTACTCTGG GGCTGAAGA GCTTAGATT7 CACCCTGTAG GACAAAATGG TAGGTAGAAA TTAATGGGTG GAT7GTCATG TATGTGTGAT GTG=FTAAT TGCTITAAT TGATCAGTCT CCCTGTAGTA TGAATAATGT AMGAGGGG AGCTAATTTA AAA'FrGTGGA ACTCATCTAA TAAACTATTG CAAGAATCTA GAAGAAAGAT AATGACGGCA ATGGTAGTAG AGT7GACAAG TGGAAGACAA ATTAGAAAAA CACTAAGTTG TAAAAATrGG TAGAATG ITA CCCTGCATAA ATGTTGGGGG AGTTAAGAGA GTCTCATACC AGGGTGCCCA TGTAAATGGT GAT7CCACAT ACTGAGATAA GAAATACGAA GAGAAAAGCT GACTGGGAAC AATrGG=m ATAGTCT1T AAACATCCCA AAGGACATCC T7AGCATATF TGAGTTCAGA GCTGGAGATA GGC=ATCAG TCCAAAGATC ACATAGAFT GTGAGTCCGC AAAAGTCAGT AAGMIJGACC AAAGGATACA TGTAGATrAG AGTCAGAAGA GCAATATACA AAAGACAAAA GCTGAGAAAT TATAGTAGTT TATGGTCCTG GATAAGTGCT CATGAAGGAT CTCAGGAGAA ATGATCACAG GTAGAAAGAA TGAGAAAAGA GTGATATGAG AGAAACCAAG ACAAAGAAAA GTAAAATGTI' AAAAATGAGT GAAATAGGCA TACCAATAAT TAAAAATGAG TAAAATAGGC ATACCAATAA CATAAGGGTw7 AAAAAATAGA GTCAAAAAT GGGGTGAGGG TAAAGTATrA GGAAGGAGTC ATGGCCCAGG GATCAAGTGA AATGAGTrAG ATCTATAGAT CTATI1CAGT TGGTTGACAT 'I1AAATGTAT MIGGT1TA ATrr=ATT GTTACAAAC ATrGC'rn= TAAAAAATTA AATTGTCCAA 'FrCAAnrCAG GCTCACAAGC AAGTGCCTCA TATATACAGG CATITGTGG ATCCCAAAGA TGCAATGATA AATAGGACAC 'rACTGATCT CAAGAAG71r TCAGTACCAG AGGAGACGGA CAAGTGAACA GATGACTrCA ACATAAGTGG GAGAAATGAG GAAGAAATAT GTGGAGCTAT CAGAACTAAG AAAGCTrCCT AGAAGAAACT GTCITGAAC AATGTCTrAA AGATGACATG TITITGGCC ATGTGCAAAA TGAGAGAGAA GGCCACCAGC AAAGTCAGTG TGCTACAGAG CACATGTG17 AAGTGTGGAG AACTGCAAGA AGGAAAGGAA CTACTAGAAG GAAAAAGCAA GATACTT17CT GGGTAACTCA GCCTCCTAAT GATAAATGGC ATAGn'IT CCAGACCTA GAGTTCTAAT TAATCTAACA AGCTCATTAG ATCGTGAGCT TCTGAGAGC GGGAATCTAC CATGCTAATT CCTrATGGTA ACCCTGACAG CT1TATCCC AACACTGTGC TTCTrGTGGT ACTCAAAAAG AC'FrG'rrGAG AAGTGAGTCG AAACTTCATG CTGACTTATG AAATC'=AC GGAAAGGTAA CAATATrGTG AAAGCAGAGC 'TrCTGATCA AAACTI'CCCA T~CTCAGAG TGGCTAGTAT CATITGT7C CAACCAGCT7 CATGATAAGC TATAATGA F7 CCTGTGACT TACCTAAGAA GAAGCAAAGA AAGGAAAGAG ACTTACCAAA CTGACACTGG GGCCCATAGT ACCCCACATC ACAGTTGCAG GTGTAAFrAT TGATGAT17C TACACATTCT CCATGGCCAC TGCATGACCA GGGCTGGCAA GAAGCIIAA GGAGGTCAGA AAAAAAATAT TTAATGTGA TTACA'II1A GTACTCAAAG TCA ITVT AGACATAGAT AACCITGT CTGAGATGAT TTrAAATAATC AGGAAAGGT7 TA'T1rGTAAA TTCATAGCAT AAAAATCATA TGCTAAAATI' TIACGTATA AAATACACTA AGCATATAGT CATAGGCAFI TA'T1TGCF1 TGGAATGAAA TTACCAATAC TAATATTCTG TAACACTrAT AGGAAACTIA GTGGCATACC FTGAAACTCT TGAAATTACT TGTITIAAT GAGTGAGAAG G'ITAAATGAT GACCTGACCT CAATCAFF1C TGCATGCAAT TATTCIGG CAATCCCIT WO 00/09525 PCTIUS99/1 77-12 EPI-109 130 C'=ATAGAA ATCAAAGATT AAAAAGTCCA AAT'GCTAA AACG1GTAGAG TCCANITTrAT AAGAGACCAA ATTAACTATG GrrCATrATr AAAACATCAC TTGGAAAATG CTGGCTGT~ TGGAAUrGTA GAAGA II1A CAGAAATA Fr CATACACCAA AGATAGTGCA A'T1TATAT AAAATTATAT AAGGTrAGAC CAAGAAGGAA GCACGCAGCA CCACACTCTC TACTTCACAA TGTGAAAACT GAGGTGATGT GAGCCTAAGT 'FrCCAACTGG CCCCAGCTGT CAGCTrCTCC TCCCCTGCCT TAT7ATCAAA GGCACTGAT-f GTCTAGCTCT TCCTCTGTAC TTCCTACGTA GiATCTATCAT MTGATGTAA CrrGA'IMAG GGGTATAGCT MFIGTGCACA GGGACAAATC TTACACACCA AAAAUTCTTA GGAGTGACAC GATGCAAGAT TATATAGAGG GCTAGATGTA TI=AGAATG AACCAGAAGC TGTrCTCATC CCCCCACCTT TCCATGGGGT AAATCTGAGT ATTCTCITrAA CCGTGGCCCT TCCTGAGTCT GAGGCAGCAT AGCCGT=~G TCACTCCCTA CCTGTGTAAC AGAGGGCTGC VI=AG TI'7G TGGCAGGCGT CATCGTrCCA M~GCCrGCA TC1TGMTC TC11GATATA GATCTCCACG CAGTCCTCCT TGTTCTTCTT GrrcrrrGGGC TCACCATCTC CCCAGTrCTC TGCTTCTTCA GTAAGAGATT TGTTGGTTCC CACCCACGTC CATATTCGTC CTATCTrCCG GAT1TCCTATC CAGTAGTAAG AACGACTGAA AGGCAGAGTC TTCTCCAGAT ACTCAAT1TrC CGCCTTGMI TGTATGGCAA CTAAATCTGT GTAATTGTCT CGGCAGAATC TFrCTAGCCCT 'FrGCCAG FrC ATGGG TI= CAGAATAATG GTAAGTCCAG CAGTCGGTT1C CATGATGTGC CAGGAAATCTr GCAAGACATC AGTGTGACCT ATGCAGACTr ACATAATG117 ACAGCTAAAA AGAACCTAGC ACTACTCCAG GCTGAGCTAG ACACTTAGAG ATGAGGAAAC AGAGCCTAAG AGTGTATGTG ACCATCTCAG GATCACAGAA TAGT~TTMG CAGAM1GAA GTAGAACCTA GACCT7CTGG CTGAATATA AGATGCT1= ATCTAAGGTI' CTATTTGAAA CAAAITAGT GGTFICTAG GTTATIC T17ATTAA T1 ITCTCAAA ATrA'IMCAG GTGAAA'ITA ACCAACATAT FIAGACArr CATA==CT TITITGTA GCTGTI'AATG ATIT7ACAACT AATTACCGTG TAATATCATA TAACTATACA AMTACGTAT ACT1TFAAT CCTGGAATCA =TCTGAAG GCCAACACAT ATGTACCTAT GGGAGAAGCA TAATAAGGAC AGGAAGAACA GTGACATACT TAAGTAAC CTCTITACA TAAAAAACAT ITrATTIAC CATAGGAAGA ACTGCT'rCTG GAAAAGCCCA ATATACCACT CAACTCIAT ATATCTAACT GTATAAT=T TAAAAAGAAC AA Tr7ACAAA GCCAAATGGT ATAGGA17AT GAAATTCATr AGATCATG'IT CTATACACAA AGAGACTCAA CTGATGATGT 17AATAAACA TATGGACCCA TCAAATATGA GGG=~rGAA GATATCTAAT TAAACACATA A'ITACACAAT GACTCATAA TAATATATGG CATTCTAAGC ATGGTATGAT CTACATGAAT CACTA'1AA TACAGTAAAG AAACAGATAT AATTGATGGT AAAGAGCATC ATAAAATAAA CATI=GAAC AGAG'ITIGA ATGAGCATI7C CACTAGAATG CAAGT7CTAA GAGGGAAAAA ACTGTITGTGT CCACTGCTGT ATCCTTAGTG CCTAGCATAA ATTrCACACA T7GTAGGGAC TCAGAAAATA CCTGT7GTAT GAAAAGAGCA CTAAGMCTT ATGTGACACA GTGCAGACAT GGCATAAGGA ATGTGTGAAC GGGAGAG77A GCATGTTTGC TTGGCTAGAG CTGAAAATCC AGGCTAGGGA GAAAGAAGAC ArTAGTIAC TTAGGAAATG AAAAACCAAG TFCAAAGCTA 7GCTGGAGA GTCT7CAAGA ATCAGATATA AAA'I7rGTCA CAACAATGGG AGAAGGACCA AAAAATGATA AACCCCCGTC CCTAATAAG CTCGTAT7GT AATTGTAGAA ATGACATrAA TGTACACTGA ACTATGAATA AAAAATAGAA AATGAGGTGC TAAATA'IMG GTACAGAT7G TAAGTACCTT AACAGAGATF7 TCT[AA TFAA CA'ITATrCCrT 'TATAATTGA GGGAI=rGT GGGGTTAITG GGAMTGAAC TCTACAGCAT GGGCTA17AT AGGTTAAAAA TAGTGTTCAG GAGTITCTGG GGAAGAACTA AAGGTAAGAA GAAAAGAGAT GnI7ACAGAA GGGATAGAAT TAACAGCTCT GTGAAATAAT TTTCCCTAG ACTATGTATA ACTAGTGGAT A'1TrAAGAAA AATGAATATA AGTAAAATAG ACTTAGCGAT ATATAAATAT CATAACATAC CACAACAGAG CATrGTCCAC CCCCACAACT TGAAGATGI1 CCATAAGTCC CTCTGGGTGC TCTGACA ITr CCATGGAAAT ATCTGCAAAT GAAATACAAA ATTATAMIA GATGTATACT CTAAACCAC ACATT17ATAG C='TGAGGT GGTGCT7ACA ACI=CTrTAA TAATCAGAAT AAAACACATA TGTCTACTAA CCCTGTCTGA GGTAACAGGT 'TrCTCAGACA TAGATGAAAA A'TACTrCAA A'IMACATCA GAACTGATGC ACAGT1TGT 'ITGTrCTAT 'IMAI=A CGCI=AGTC TCAAGTTGCT AATCGGTACT GCCCTGAATIT TITCTATGG '1TrGGTAAT7 'IMATACCTG CTITCTGCT GAGCTATrAG ATAAAACTAT TAATATIA CTATGTATAT TITTAAAGT ATTGTTGCTG CFFAATTAAC TAT7GATGCT TATA'ITrAAT cYTrATAGCCT CAcTCTGAT CATAATGGGT CAATGCCTCA AATACCTAAA AAAAAAAAAA AT7AGATAGC CAGACACCAG GAAAGAAAAG TA'TThTIT MI]AATAAAA AGAAATACCT I=rGAGCAA CTGAAATGAC AAAGTCACAA A'Ir7CCTGCA CACCT7AAAA TATACTrAAT GTAAATGACG AGT7AATGGG TGCAGCACAC CAACATGGCA CATGTATACA TGTGTGACAA ACCTGTATGT TGTGCACATG TACCCTAGAA CTAAAGTAT AATITAAAA AAATITCTATC TTCCAAAGCA TATCAC'ITCT CAGGTAGACA CAGTG'ITrAT TGCAAAAGAT CTGATTTCAA TAGTATT7CT TCAAGAGTCT CCCCAGAGAC AAAGTCAAGA AGAGGAAATC AGCATATCTG AGAAGAAAGA TT1TCAGGATC ACrTTTG AGGGTCTGAG AAAATGTTTA G'I=CTATAT TAIT]AAAAC CAGAATTGAA ATGGGGTGAT TCCTATCC'Fr GCCACCTGCC TCTACAACCC CAAGAG'T~rC TATCTGAGCA TCTAAACGTC TITAGGCTG AAAGGCTCAC CATGGC'=G CTTGGTCCT CTrCTAGTrCT TCTGCAGCCC A'ITGAGCCTC TTGACTTAGC ACAAGGGTCT CAGGTCCTTrG CCCAAAGGGA GTGTGCTGTG CTGCAGGTAG ACTGCACTGA ATGTCAACAG AAAGCCTrGC T1TrCI=CAT TIX1rCTAACC CAGTCTCACA TCCTCCTCCT CCTCCCC'TI TCCCTCCCCT TCCTCCrGCA =~CTC'IMC CTCI=CCCC ACCCCI=CC TAGACTGGCC TCTATrGCCT CCCACTGAGA CAAAAATGAA CTGCTGATCA GAAAGTAATG TGACTAGAT~r CTCTCTrTCCT TCCCTCCI= CTATCC'ITCC TrCCA'TrCTC CTATGCATCT TrCCTACCC TCCTCCTCCT TCACTCATTG rrGTrGCTGT TCT7CT7CCT CTrC'TI=C CTCCTGCTCC TCT'TCTCTA CITGTrCTTG 'Tr=G=l TG'IMGG'rrC T7GflCrCCT CTTCCTCCTr CTCTCTCTCC TCCTCCTCCT TCT=lCCAC CACCCTCCCC TATC'TITIC ATAAATGCTA AACTAACTCT TGGCTACCTG TGGTAAATGG CCCT7GGAAA TTGCAAATAC TACAAATCAA AACTGCA'IM CAGACATATT TATGATG'IM GCAAAACTFC AGTAGAGCTA AGCAGTGGAC TTGACTCGTT TCGG'TCCIT CACCTCCGTC 'ITCCTrGCT CACCACCTAG TGGACGTCCT TGTTAGTGGC ACTCCTGAA GTTAACCCCT GAAGAGAGCC CATGCTCTCT AGCTITCAC CGTGTAGGTT TGGGAGCCTA CAAGTACC'I TAATATrC= GGACTATAAA ATGAGATGGT 'IMATAAGAC TGCATGTGAA A'FTAGGACCC ATATGATGAA GGACAATAAA AAGGAAGACC CACTGATGTG AGTCAATGAG TCAAATGCAA ATCAGA'Tr7G CA'II=AGG AAAATAATAA TAACAACAAC AAAAACTCTG AAGCTCAGCG CCCCATA'M A'FATATTGT TTAATCTI17A TAACAGCTCT CTGCTATAGA TATGATTATT ATCCCCA'ITC TAAAGAGTCT CAAAGAGGFTr AAGAAACAAA TTCAAAAACT AGCGAAAGAC AAGAAATAAC TAAGATCAGA GCAGAACCAT AGGAGGTAGA GACACGAAAA AGC=TCAAA AAATCAATAA ATCCAGGAGC TGCA'IIGA AAAGATTAAC AAAATAGATG GACCACTAGC TAGACTAATA AGAAAGAAGA ATCAATAGAC ACAATAAAAA ATGGTAAAGG GGATATrACC ACTGATCCCG TAGAAATACA AACTACCATC AGAGA~rACT ATAAACATCT 'ITACACAAAT AAACTAGAAA ATCTAGAAGA AATGGATAAA TTCCTGGACA CATACACCCT CCCAAGACTA AACCAGGAAG AAGTCAAATC CCTGAATAGA CTAATAACAA GTTCTGAAAT TAAGGCAGCA ATJTAATAGCC TACCAACTAA AAAAAGCCCA GGACCAGATG GA~rCACAGC CAAAT7CTAC CAGAGGTACA AAGAGGTGCT GGTACCATTC CT7CTGAAAC TATTCCAGAG AATAGAAAAA GAGGAACTCC TCCCTCACTC A=F~ATGAG GCCAGCATCA TCCTGATACT AAAACCTGGC AGAGACACAA CAAAAAAAGA AAA'TCAGG CCAATATCCC TGATGAACAT CA ITGCGAAA ATACTCAATA AAATACGGCA AACTGAATCC AGCAGCACAT CAAAAAGCT ATCAACCACA ATCAAGTTrGG CTCATCCCT GGAATGCAAG GCTGc3TrCAA CATACACAAA TCAATAAACA WO 00/09525 PCT/US99/1 7712 EeN-I 09 131 GAATCCATrA CGTAAACAGA ACCAATCACA AAAACCACGT GA'F[ATCTCA ATAGATGCAG AAAAGGCCTT GGATAAAAYF CAACACCCCT TCATGCTAAA AACTCTCAAT AAACTAGGTA TTGATGGAAC GTATCTCAAA ATAATAAGAG CTAM~ATGA CAAACCCACA GCCAATAGCA TACTGAATGG GCAAAAACTG AAAGCG FrCC CT=AAAAAC TGGCACAAGA CAAGTATGCC TCTCTCACCA CTCCTG'FrCA ACATAGTAT7 GGAAGTrCTG GCCAGGGCAA TCAGGCAAGA GAAAGAAATA AAGTGTATrC AAATAGAAGA GAGGAAGTCA AATTGTGTCT G ITGCAGAT GACATGATFG TATAITT7AGA AAATCCCATr GTCTCAGCCC AAAATCTCCT TAAACTGATC AGCAACTTCA GCAAAGTCTC AGGTTACAAA ATCAATGTGA AAAAATCACA AGAAMTCCTA TACAGCAATA ATAGACAAAC AGAGAGCCAA ATCATGAGTG AACTCCCATT CACGA'FrGCT ACAAAGAGAA TAAAATACCT AGGAATCCAA CTTACAAGGA ATGTGAAGGA CCTAT7CAAG GAGAACrACA AACCACTGCT CAAGGAAATA AGAGAGGACA CAAATGAATG GAAAAACAT-r CCATGCTCAT GGGTAGGAAG AATCAATATC ATGAAAATGA CCATACTGCC CAAGGTAAT7 TATAGATFCA GTGCTATCCC CATCAAGCTA CTACTGACTT ITICACAGA ATTAGAAAAA AACTAC=rA AAITI7CATAT GGAACCAAAA AAGAGCTTGT ATAGCCAAGA CAATCCTAAG CAAAAAGAAC AAAGCTGGAG GCATCATGCT ACCTGACTrC AAACTATACT ACAAGGCTAT AGTAACCAAA ACAGCATGGT GCTGGTACAA AAACAGATAT ATGGACCAAC GGAACAGAAC AGAGGCATCA GAAATAACAC CACACATCTA CAACCATCTG ATCITGACA AAGCTGACAA AAAGAAGCAA 77GGGAAAGG A ITCCCCA F[ TAATAAATGA TG~rGGGAAA ACTGGCTAGC CATATGCAGA AAACTGAAAC TGGATCCCT[r CC'I7ACACa TATATAAAAA TrAACTCAAG ATGGATTAAA GACTTAAATG GAAGACCTAA AACCATAAAA ATTCTAGGAG AAAACCTAGG CAATACCAT7 CAGGACGTAG GTATGGGCAA AGACTrCATG ACTAAAACAC CAAAAGCAAC AGCAACAAAA GCCAAAATIXI ACAAATGGGA TCTAATrAAA CTAAAGAGCT TCTGCACAGT AGAAAAAAAA AAACTATCAT CAAAGTGAAC AGGAAACCTA CAGAATGGGA GAAAATFVF GCAATCTATr CACCTGACAA AGGGCTAATA TCCAAAATCT ACAAGAAACT TAAACAAAITr TACAAGAAAA AACAAACAAC ACCATCAAAA AGTGAGTGAA GGATATGAAC AGATGCTIrCT CAAAAGAAGA AGTrATGCA GTCAACAAAC ATATGAAAAA AAGCTCATCA TCACTGGTCA TfAGAGAAAT GCAAATCAAA ACCACAATGA GATGCCATCT CATGCCAGT AGAATGGCGA FrATTAAAAA GTCAGGAAAC AACAGATGCT GGAGAGGATG TGGAGAAATA AGAATGCT1 TFrACAGTGT'r GGTGGAAGTG TAAATrAGrr CAATCATTGT GGAAGACAAT GTGGCGATT17 CTCAAGGATC TATAACTAGA AAAACCATr GACCCAGCAA TCCCA'ITACT GGGTATATAC CCAAAGGAfl ATAAATCATr CTACGATAAA GACACATGCA CACTATGTTr TA ITGAGGCA CTATTCACAA CAGCAAAGAG T7GGAACCAA CCCAAATGCC CACCAATGAT AAACTGGATA AAGATGATGT GGCACATATA CATCATGGAA TACTATACAG CCATAAAAAA GGATGAGTrC ATGTCCITG CAGGGACATG GATGAAGCTG GAAACCGTCA TTCTCAGCAA ACTAACACTG GAACAGAAAA CCAAACATTA CCCAflrCTCA CTCATAAGTG GGAGTTGAAC AATGAGAACA CATGGACACA GGGAGGGGAA CATCACACAC TGGGGCATGT CAGGGGATGT GGGGCTAGGG GAGGAACAGC ATrAGGAGAA ATACCTAATG TAGATGACAG G7FGATGAAT GCAGCAAACC ACCATGGCAC ATGTATACCT ATGTAACAAA CCTGCACGFTr CTGCTCATGT ATCCCAGAAA 117AAAGTATA AITTAAAAAA AGMTAAAAA AAGAAAGTrG CCTAGTCAC ATAACTAGTA AGAGACATGG TTGGGAATI7 GAACAGAGGC CAATCAGT17C CAAATCCATG CTCTFGATCA 'FrAAGCTGAA CTATGGCAG GAACT-rGGAA GACATGGTAA AATGGGGAAA AACGTGGAGC CAGGGAGACT TGTGAAAGTG CCAGTGCTCC CACTATACCC TGAAAGAAGT ATCTAGACTr ACFITITCT AAGTCCTCTC CTCTAAflCT CTCAATcTcTr CTCTCTCFI CTCTAAGAGA TGGGAATGCT GCTCTrGTCAC TCAGGCTAGA GTGCAGTGGT GCGATCATAG CTCA17GCAC TCAAGGAATC CTAGGGTCTA GTGCCCCTrC TCCCTCAGCC TCCCATGTAG CTAAGACTAC AGGCACATGC CCCAACCCTC GACTAA'1h TA'TIr ATI=GTAG AGACAGGATC TCA~rATGT7 GCTCAGGCTG TAAflCTGTC 'TTGAAGCTG TCCAATCAGG C1TCAGCCA CACCAATFTCC CTGAGACTGC TCTCACCAAG GTCCTACACT TCACTAACAC AAACAGCCTA 'TrCTCCATCC TCATCT7ACT TCACCAGGGA GCTCCTGGT FrCCTCCTAC FrCACTGGCT AT7rrcTTG TATCATGTGT TGATTrCTCCC TCATCTCCCC AACCTCCAAA CCCTTGGAGT ACTCCAGAGA TCACCGCIT GCTCTTCTGT GTCTAACCTC ACTAACT'rGG TGGTCCAATT CACACTCFG ACTIGAATA CCAMIIAAAT GCGAACGAAT TCTAAATrCT GTACAACCAG AACCATrCTC CTGTAGCCAA ATGCCTACTC AACATCTCCA TCCCCAAACA AAITIAG117G TrCAATAAGC CTCTCATA17 TTACATATCC CAAACTGAAC 'FrCTGAATr CTCCI'CCAAT CTGTAGGGCT CTrCCCACAG CC1TCCATC TCAGTGGATr ATAACTCCAT CCrrCCAGrr ACTCAGACCA AAACT=rGG AGTTAACTGA GACACCTCTC TI1TTCA CAAGTCATAT CCAATGTGTC AACAAA1TF7 GGTAGTGGAA ATATrGCGGG AETIrAAG AAATCAGAGA GACCGATGGG GTTCAGGAGG ATAITIATTA ITFAGGTGCA CTGGCCAAGT CAGATAACA TCCAAAGGAC TGAGCCCTGA ACAAAGAGT7 AAGTT]ACCT7 FI7AAGCAMT TGTGGGGTGG GAGAGAGGGG TATCTGTGCA GGGGGAAGCA TACTACAGAA GTGAGAAATA AAGACAGTTA 'CAA~rAAT TGAGACATGC ATTACATCAT 'FrCTTACTI TCAAGAAGAA ACATGrT=G CGAC=GAGT 'ITATCTGTCT AGTGAC=TG CAGCTGCACA GCTAGAGAAA CAGGGTCTT1C ACAATGCCTG GGAAAGGAGG AGAGGTAAGT CTCACTAGCC ACAGAAAAAC AGGCAGT-rAA ITTAAAGG GCTCCAGCTC 1TFCTC'=C TCAGGGGGAG 7FGGGTF=G 'rTACATACAA CTGAGICC GCTTACACAT TA=~AATI1r CFI=AArrC CTG'ITCCAAA AGAAGCCAGA TACAAAAGGT TACATGflGT CTGATTCCAT FrATATGAAA CATATAGAAG AGGTAAATCC ATAGAGACAG AAAGTAGATr AGAGGTTCCC AGGGGCTGAG GAAGAAATGG GGACTAACrG C=IATAGGGT ACAGAGTIT CT7CrGATAA AAATATITG GAACTAGATA GACATITGT TAGGCCATTC 'FrGCA'FrGT7 ATAAAGAA'T ACCTGAGACT TGGTAATITA TAAAGAAAAG ATG1TAATT GGCYFACACT TCTGCAAGCT TrACAGGAAG CATGGTGCCG ATATCTGCTC AGCTICTGGT AAGGCCTCAG GAAG=fACA ATCATGGCAG AAGGTGAAAG GGGAGCAGGC ATATCACATA GCAAAAGCAG GAGCAAGAGA GGGATGTGGG GAGGTGACAG TCACTI=AA ACAGCCAGAT C=GTGAGAA CTCAT7CACT ATCATGAAGA CAGTACCAAG AGGATGGTAC TAAATCAT7C ATGAGAAACC CCACCCTCAT GATCAAATCA CCTCCCACCA GGCCCCACCT CCAACACTGG GGATTACAAT TTGACATGAG A7F17GAGTGA GAACACGGAT CCAAACCATA TCAGAGATGG TGGT7ATACA ATGCGATAAA CGTCACTGGA T7GTACACTI TAAGATGG Fr GTITATGTr GTGTGAA=T CACCTCAATA AAAAAAAATA 'ITrAATGTAC AflCAGCCAA AAGAAGAMT GGAATAGGAA AGGTCATGGA GATATATTAA CAGCCAMTG ATGGGTGGTA AGGAAAAGAG TGGTITATTAG ACTG7TIGT GGCCCTCAAA AGGTAGAACT AGATCGAGTT GGTGAGCATr ATAAAACCAT CACAAAACCC TGGAGAGAGG ACCCAGTGCT GAAGAACCGT TTGCCrGCCA TGAGACATGA GGGAAGTACC AGTGAATGCC ATTGAAAGCA GCATCCCTGG GTCCAAGGGA TGGTCAAAGG ACCACTACCC AACCC17CCC TAGCCTACGC CTCCATrACA GATGACCGCA AGAITTA'I GCTCA'TFGCT GCCAACCAAG GCTGCACTCA CTGCAGTTGC TATCAG'TI'A TCATGGGTAA AAGGAATGTG CAGTAGAGAA CTAACTAACT GCCCACCTAC CTCCACAATC CTATCAGGAC AAATCACCAT GGCTCACA17 TCMTACAF] TGGCATGTAA GCCCCTCTTA CTGTCTGTCA TCTrATCTCCT ACACAGTrCA CCTAAACTGT TCTCTCCTGA CCCAACcTG AT1T7CATCC CAAATGCTTC CTTGCCATCT CTGGGATTCC TGTCT~rCACC ATCACCAAAC TCCCCTCAAT CTTCCAGMF CCTGT-rCAAA CTITCTCCT ACCTCCTTGC TrTGTCA'rA GCCCGACTGC CrCCCTAGGA CATCACTTCC CCTGCAGATC TCTCAAGATG ACAATATTTA TTCTCCACAC AGCACATACT TCAGGGITGG AAGGCAGGGG CAATCTCTC CITATAATG AGTGCCTC= ATATATGIM AT~rCATCTGC CCT=GTAA AACACACACA CACACACACA CAAAGAAGAA ATAAAATAAC TCTG=TCT TGAAGCTGT GACACTGAGA WO 00/09525 PCT/US99/17712 EPI-109 132 TAAACCATCT CACTGTCCTC ATI'GTAGTGA CCTCTCAACT CCTCATGCAA GA'FIGGC'TI GGCACCTAGT TCc-TGATcTT C=T1CCCTG TAAGCACTTC TCATAGTC'Fr ACGGGACTTC ACCATCCATG GCACAACCAA TACCACAGCC CAGATCCTCA GCTCTCCAAT GACA=1~CC TCCACTAGAC 'ITGAGCTACC TCCTTCCCTA GGCACAGCCT CAACCTCGAC AACACCTAAG ACTGTACCGT CTCTAAAGTC ACATGTFCAA ACACTrCACr C'F=AACCAC TGTCTCCTAT TCTI7GCAAGT GTATrGCTCA AGTATCTCAT TGCAATGCT TrAC'rCTA CCTCATTGAA CCTCCAGGCC A'FrAAACATr TCCTrA'TTC TAACCATCAG GTITCTCCTT ACTGTI1GT TrGTPT7ArI G'MCITMI Tn-TMTT ITGAGACAG GGTCTCACTC TGTTGCCCAG GCTGGAGTGC AGTGGTATGA TCTCGGCTCA CTGCAGCCTC CATCTCCCTG GTTCAAGTGA 'FrCTCATGTC TCAGCCTCCC GAGTAGCTGG GACTACAGGT GCATGCCACT ACGCCTGGCT AAGAT1TGT A7I1TATTA GAGAAGGGGT 'TrTGCCATGT TGGCCAAGCT GGTCTCGAAC TCCTAACCTC AGGTGATCCA CCTGCCTCAG CCTCCCAAAG TGCTGAGATT ATAGGCATGA GCCACTATGC CCCACCTGGT 'FrCTCCTTAT TTAITFCAAG TCTATGCTGC ACTATFAAAA CTGCCTTGAC AAAAATTATA ATAGTGAGAA AATTATGACA c3TGAAAGAGA TCTGAAATAA TCAACCCCCA TCTI'GCCI ACCTlCCAGA CTGCCCTTAA TAATTCCTGA GC'17GGGCCA AGCTATCTr GGCAGAAATT TAGMrATAG TMAAATGAT AATAGCCCTT CTCCAAAACT AAACTGCC= TGTAAAACTA ATAAAAGACC ACCAATGAAA GGTTAGGAGG ATGAGAGGAG CCTGAATTCT GCTAAGGTGT AGATGTAAAC AATI'ACCAAC TGTI'AUCCG GAGGTCACAA GA717GCAAC ATCGCCAAT'T ACTCGTGCAG ATAACAGCAC TATCATAGAA TCTGATrGGC CT=~GAGAT GTCTITCAG ATTCTTACAT 7rCAACTGGT GGCTCTACCT GGACCCATCA ACAAGTCCTG TGGCTCCACC CAGAAGCAGA CTTAACATGC ACAAGGACCA t=FCCACAC CGCTATGAT7 GCATCCCAAC CAATCAGCAG CAACCATrCC TCTGCCTGCC AAATTATCCTr TGAAAAATCT TAGCCTAGA Ar1TGGGGG AGGCTGATT CAGTAATAAC AAAACCCCGG TCTCCCAM GGCTGGCTCT GCATGAATrA AATTrCf CTATrGCAGT TCCCATCTITG ATAAATCACC InrATCTGGG CAGCAAACAA AAGGAACCCA TrGGACAG'T ACACTG FrGG CAGATATATC TrGC'ICCAA AATTGGA T T17GM~AATG AAT~rATrCT G=ITCTTGA TATIACAAC TGTGAATGTT GTGTCTGAAT TcTC'ITTf TC'G'T7GAA AAGAACTATA TrGCTACAGC CAGTACATAC AGATGGATAG CTAATrACTC AACACGGGGG GATGTG1ACCA TCACCGCACT GTGCAAATGA ATGT7ACCCA TTGTCCACT7 TFTCCCAAACT ACATAGTGTr ATATGGTATA TGACCCAATC AACGGTGGCA AAGCTCCAGA AATACCACAT AGACATCAGG GACACITAA ACTAATCAGC CTATAGTCCT T1TCAGTAA TFCCAAACC TGG'FrGTGCA TCCAAATCAC TTGGTAACAT TAAAAAAACA AAAAAATATA CACGCAACAT TCGCTCCCAA TCCTACTGAA TCAGAATATr TTGGGTTGGT TCAGGAACAT TCAGGAGTrT TrCAGGGTCC AAGG'T7ATA TAATITGAGG TCT1CT=G AGAAAAGGAA CGTAAAAGCG TCTGCT=T ATAGATCTrA CAAAGATGTA TTACCATGTA AACACATrCC TAGGACCCAG GCCCTTGTAA TTTAAAGG'Fr TATCTAAGTA ATGGGCCCTG AAGCTAA'T 7rCATTATCT TCAGGGCAAA TTACCTGTGG GTTAGGGrT AGGAATATAT CTCTCTGTGT ATGTGTGTGC ACATI7AGCAT GTACGCTIGT GTGGArTr 7ITIFIrT= TfTTT C TGAGACAGAG TCTCGCTCTG TCGCCAGGCT GGAGTGCAGT GGCGTGATCT CTGCTCACTG CAAACTCCGC CTCCAGGCT CAAGCGA'FrC T7CTGCCTCA GCCTCT7GAG TAGCTGGGAC TATAGGCACG CACCACTATG CCCAGCTAAT FI=GTAT1T TrAGTAGAGT TGGGGMFCG CCATG'FrGGC CAGGATGGTC 'rFGATCTCr GACCTCGTGA TCCACCCGCC TCCACCTCCC AAAGTGCTGG GAY7ACAGGC GTGAGTCACC ATGCCCAGCA CTTGTGTGGA TGITI1AAGC TCCCAGGTGA GTGAATACAA AACTAGATCT TCCCTrCTG TAGCATCTGT ACTGTI1ACT CTATGCATCT CAATATr=r TC'IIAGTA TC = CCTr CTCTCTFA T7ACT-rCCTC TrGTGCTATT M~ACACCTC CITIMrAAA AAATI1TC CCITIAnIT CTATTGACCT 'f7AGCCCTCA CAATGATrCC TACAAGCCCC ATTTCTGTAA ATGGGGATrG AAATAA1TGC TGGACTITG AGAGATAGAT ATATrAAATr GCAAACTGGC AGTAGTGGGG GCAGTrGATA CATAACTAGG =IFAAAGTC TAGCCTTCTG AGACCACTCA FrCCATrGT GAAAAGTGAT TCTACTTCT7 ATTATGAGCC AAAATATGCA TTCATTCACC CATGCAT7GA =TAT7CAT7 CAATAAATAT TrG'ITGGATG TCCACTCTGT ATCAGGAATG TGCTAGGTTC TGGGAATACA GCAATGAACA AGGTAA'T TCCCTACCCC TAAGGAAC'F AGAGM~AGT GGGGAAGACA GACATrAAAC AAACANFIXIT GCAAGTAATA ATCTATAAT7 A=TATrACA ATTAAAGGAA GGAAGAGACA TATGGA'FrAT GAGGGCATrA AAGAGGAGAC CTAGTGTAAG TAGCCAG'FrC TCGTGAAGGG ACATGTATTA GTTGGAGTTC TCCAGAGAAA CAGAACCAAT GGTGTGTGTG TGTGTGTGTG CGTGTGTGCG TGTGTGTGTI' GGGGTGTGGG GGTGTGGTAT 7TTATAGA AATrGTCTCA CACAATTATG GAAGCTGAGA AGTCCCATGG CCTGCTGTCT ACGAGCTGAG AACCAGGAAA GCCAGTGGAA TACTTCAAAG TCCAAAGGCC CTGGAACCAA GAGTGCCAGT GTTGGAAGGC AGGAGAAGAT GGGTGTCCCA GC~rAAAAAG ACAGTGAA'Fr CACTCTI= GCTCTACATA GGGCCTCAAT GGGTFGGATC ATGGCCACCC ACATTGGTGA AGGCAATCCT CTrAGTCTAC CAATITAAATA CTAATCTCTT TGGAAATACT CTCACAGACA CACTGAGAAA TAATG=I1A TCAGGGTGAT AGAAATC=C TGGAGTrAAA CAATGGTGAT AGCTGTACAA TCACATACAT TIMAAAGGG TGCG=IrAT GGAAAGTGAG YITATCTAA ATAAAA'ITC TAAGAAAGAG A=~AACACA GAGATAAACA TAAGCACATr TAT17GTCAAC C'=ATAGTG 'FrATGTCAAA TAGGTCTGAC ATAAGC'ITAA ATAAATATAT A=WIAAAAA TrATAAAATA ITFAAGrrA TAAMAAAA F7CTCAATAA AACTCAAACA CAAACCACAC TGGTA T7CA CACAGCTAAT TTCTAATGCA G'ITACATAA ATA'ITACAA CACTrAAACA A ITCAAAGA AAATAACACT GTATrCCATA CATAGCCTGA TCACAGTAGT TGT17CTCTCT TArTCCCAG AG TITCTG CCCCTFAAA AGAACCTCTG CTGTTCTGAT C=TATCACA TCTCTGT1T GACTGTI'GGC n7~GTrGT7G CCAGTG FFCA GCCAGAACT7 CTCTGAAACT TTTrTCAA CACATGCTAA G'TrAATGGAA GTGTAGGAGA G=F~GA'FrC TCACACTCCT CAAGGCTAGA GCAGC1TGG CAATTACTGA CTGAGAAMTTT'rCATGCCA GTGATCAACT GAAAACTGGA GATTrCCFG GAAT7GITAA ATCTGCTTAT AAATAAACAT AAATG=~GC TCACACAGGC A'TCCTCTCT TCCAGAGCAC CCTAACATAC AGAAGAAAAC AAATAGGGAA TAACTAITrAG ACATCTrCAT TCGTrAAAAA TCTACCAGAT GACTCTITA CATGGTGAGT FICTAUrGTG AA'I1AAAAT CICCATAAT ATACAAGAAT TATGTT"TACA TATCATATCT GACAAACATC 'TGTAGGAA TGCAAAGCAC ATCCATCT= CTGTATTCTr TTCCAACAAA GACATTCATA AAAT7ATACC MTGTGTGTr TGCAnI7ATG CiTIAlTAG TTCAAAACGT TTGGCCTCAT GGAAGTITI CATCGTGGAA ACCACATAT7 TCTGAAAAAA TATCTGACAA TATACAAACC TrCCAT7CA G 7I=fACTCT CCAATTCTAC CATGTI=CA AAAAACAACT GTAGTAAAAA CACTCAGAAC IMATFrTGG 'ITAACATCAT GC=TGCTAG GGGACAATAG T1TrCCCTF= TGAAATAAAT 'FrAAAACAGA TGTAACATAA 'FITGTFAATA AACAATGAGG GGGTAATCTA GAATAAGTAA CT=ACCAT ATCATAG17G ACAGCAT17A CAAG'TTT AAGTCCCTAC CACACITGTA TTGAATGAAG AAGTATGGAA GATTATAATA TAYrCAATGC AAGTAAAAAT ATCACAATCC 'ITAAGAACTC 'TrAAGAAGC ACTGAATCCC ATAGGGATGA AAGTGAITrAA ATTGTGCATA GTAACCCTCG CACAGAGCAT TCAGTAGGAT TITGCACCAT7 AACAACCCTC CATGCAT7TG CCTGTGGGCA 7TCAACATCT GTCATITT TAAGTTATAA TA7FTIAGT CATITrC CTCTAAACTC TGGATAA'FrA TrA1TCATFC TATGACAGC AACTGTGTAA TCAGCTGTCG AAACACTGTG AAGGGCAAAA GAAAGAAAGC CACAAAATAT TGTG T7CTG TGCCAAGAIT TTACAGCGAG CAAGGGAGAG ITAGAAAAGG AAT7CrGAGA T-17CAGAGTC YITGGTCTCT CAC='~GCT TGGAAGAAAA TATCCTICC C1CA'ITAGC CAACA=CC T-TGATCCTGA GAGTAGGAAA GGGAACACTG AGTCTITCA G'FrGAAGGCC GTCC=GCCT GCTGGACTI GATCTATrGA WO 00/09525 PCTIUS99/1 7712 HPI-109 133 AGTGGTGATG GGTGTrGCGG T-CAGCCAT AAAGGCATCT GGCATAGTAG GCAAGAAGGG CCAGAGACCC GAGGAGAG TT ATCTGTCTCT GTTAACTrCA GTGTATCCCT CTAGTrCCCC AGATGCACCT GT1T7CTGTAA ATATAAACAT GCATGTCATC AGAACACITA ATATCTGCA TACTGATCAT GACAACAAAA TGTAC=~CT AACACAGACA CTCTCACTAG GATAGACCAT GTAGGAACAT CGAATrCTAT TCAGTTAGGA CAGTGATGAT GTCTACATAT TATACCTCTG TCAAAACCTA CAGAATATAC AACACAGCAC AGAGTGAAr CTAATGTAGC CTGTGGACAT TAATGAATAA TAATGTATCA ATATTGGCCC ATCAG'=GTA ACACTAATAT AAGATG'ITAA TAACAGGGGG AATTGAAGGG GTGGTGGGGA GATATG~rGG AACT=WGT GCTI7CGCT CAATTCT GTAAA=TAA AACCGCACAC ACAAAAAAAG TTATI=AAT TflTAAAAA GTATTCAGAG GGACTGACC 'Tr7CCAAATr CTCTCAAAGC AGGTCGGAGT AGTrAAGAAC ACAAA'rrA GAACCAGACT GCCAGAG T1 GAATCCTGGC TACACCACTr ACTAGC'=G AGA TrCAGA CAA'ITrACTr AA=TCTCTG TCTCATITC TTCATCTGTG TGATAAGAAA TAAAGTAACA GGCCAGGCCC AGTGGCTCAC GCCTGTAATC CCAGCACTI GAGAGGCCAA GGCGGGTGGA TCAGGAGTrC AAGATCAGCC TGGCCAACAT GACGAAAAAA TACAAAATCT CTACTAAAAA TACAAAAATT AGCTGGGTGT GGTGGCAGGC ACCTGTAATC CCAGCTACTC AGGAGGCTGA GGCAGGAGAA TrGCTTGAAC GCAGGAGGTG GAGGT7GCAG TGAGCCAAGA TCATGCCACT GCACTCCAGT CTAGGCAACA GAATGAGACT CCATCTCAAA ATITAAAAAAA AAAAAAGTAA AAAGAAAAGA TAAGAAATAT AGTACCAGCC CCTATCTCAG AG FTCCTAGC T7AGAAAAAT TCCCAGAATA TAATAAGTGC AATGTAAGGG TCAGCTATCT TCATTA1-rAT TATCTATCAT AAATGAAATI' ACACAATAAA GCTAGATCCG 1TTCTTCCT CTCC11TCTAC AAAAAATAAA GCAACT=CC AGAACAATAC CCAGGTGATG A'IMCTCCCC TGCTCCCrCC CTAAGATAT7 GGCAAGTITG GAGGGTTCAA GGAGAAACAG AGCATGTAGA GAAGATACCT CTCTCATAAC CAT117GTGAT 7rACAAGTCT TACCTGA11C =FTGAACT-r AAAGGATGTA AGAAGGCT= TGGTAGCTTC CATCTGA FFC AAGG=11GG CAGCTGCTGT GGAATACATG AGAACACTAG GTAAAGCACT GTC~rCCAAC ATGAAGAGAG AAAAATATGT GGAATG'I1CA ATGGCATGCT TTGTATAAGA ATGCAACT'FA CCTGGCAGGA ACAAA1T]TCT 17GCTGCAAA AGAAAAGACA AACAACCATT AATTCAGACT AAATGACTlITI TAAGGATATA 'FrAAATCCAG ATACAATATG ACTTAATrCA TCAAGTGITG CAAACTCGAT G=TCAGGGC CTCTGTAATA ATCAGAGCAC AAGCATGGCT CTGTGGCATC TAGGGTAAAA TGCAAAGTGC ACAGCCATCC AAAGGGCATA GCAGCTTCCT AATGCCAGCA AATAGCTACG GGGTCATCT GCCCAATTCA GCTCCCAATT 'IMCATGAGA AGTCCAAAGT CT-rAAITrAA ATGTGAGATr TCCTATTTG TAAACGTCAG AACTITAACTC AAAAATG'IT TAAGTACTCT TAAACATGTA AGCCAAACAA ACCATGAGTG TAGTCAGATG TGCTTCCATA T-rCC'=ATGA GAGACTCTCA AAMPAAGCC TGTACTCCAA ATAAATCTCC 7TAGGAAGAA =F~ATCCAT 'FFICCrrAGA GTGCTCATCA TGGCAGTrCC ATrGCACAAT TCCGGGAGGC ATCATATAAT TCAACATGAA TAGCACCCCC TGGAG'I1GTA CAATATTAGG CACGACTAAC A'TIT1AIT CCTGAAACAC TrCCCACACT GAGTTGTACT ACTAACTCTr T7CTTAATAC 7rCTGMTAA TTATACTGCA =F~ATCCAG ATTrCTAATTA TTG=TAAAT CAGTAAGCAA GACCATGACT TATCAATGAG AAAGAAATGT ATI=CAAAA ACATTI=GA AGTACAITCA TAAACrrCCT CACC'=CCG TAAGCKITTrC CGAAGCCAGA GGAGAAATGG TGCTAATGTC AGGAGGGAGA GTCCAGCAGC AGAAAGTCCA GCTACCAAGG GAATGTrGGA CTCAGTGGGA GCTAAGGAAG TAAGAGACGA AGAAAGGTCA TGAGGAAGAA ITGATGTrAA AGTCTCTCCG TCCTGTCCCT TrGGCC'I7r TrCTGTACAT TCATrACTAG GAGCAGAAGA GCTATCTAGT T7AATACAAG AAGCAGAGAT GTGGCATTAC AGGCCTTGA GATCTGCTCC AAGCCACCTT TGAAGCTA'IT TCCACCAT7G GCAGGCAGAA CTCTAA=rG CCAAGCTCGT TCACAATACC ACACCACACC TTGGTrAATA AACACTGCAC 117GCFIXICTC T=TGCrCTC AC7CCCTC= GTITCCATT TCCC=T'CT CCTCTCCTCT CTCTGTCTCC TI1TCCAGT TGTCAGAAfl CTACCC CATCAACATG CAACTrCTGT 'TI=rCTCTA TCCCCATACA ACTTAATA F7 CACAACTI1GT CAACCTGGGC GAAC'=CTG G'ITGGATAT AATGAATAGT TGATrACTGT AACAAGATAG CTCCCrr TrII=AA TCACCAGACA ACCACCATCA ATCAATGCAT CACCITCACA GGTAGGTAGC AGGCCAGACC AGTGTCCTGT GGCTCCACAT GTCCGAGCTG CAGAGCCATT GAGCGTCCAT Ccr=CAGGAC AGGCGAACT7 GCACACAGTG CCAAACACGG GCTCCCCACT GCAGCTCATG T7GATC1T7C CCGGAACTGC CAGGCTrGAA CATITACCA CTGCAAATGT TAGGTACACA GGCAGAGTI7r CAGAAAAATC TACTGGAAAA CTCCAAAAC rrGCTTAAAA GTCAACAATG AATGTAAAGT GTAAGCGCTA CTTAGTIC AGCATGTAGG AAATTAGGAC CAAACCCCTT TGGGGCAATC TAGGTTCAGA AAC1TATGA AGTA TTGAC CTGTACCCTA AAAAAGTCTG CACTCAKI1?C TACCTGGCA GGAAGGAACC TCTCTGTCC ATTGTCCCTG AGATGTGCAC TCAAG'FrGAG 'ITGATCCATG TAA'FrCAAAT CCCTCCTCAC AGCTGAAGGC ACAAGAGGAC 'FGTAGGTGA ATTCTCCAAT AGGGGAATGA GCACACCTCA CCAAACCCTr CGGGGGCTGG TGGACAGCAT CGCATCTCAC AGCTGGAACA CACGAGAGAG CACTTTAGAA G'I=G'IGC ATCTCCAGCA ATACG TCC CAAGGTAACC AAGTTCCCAA GC=CAAT AGTrCIr= ATCTrAAAAT AAAATAAAAA CAAAGACTGT ACCTrCACAT GTGGGCTrCT CGTTGTCCCA CTCCCCTGTG GGGCCACATr GGAGCCTIT GGATCCCTC AACACAAAAC CCTGCTCACA GGAGAACTCA CAGCTGGACC CATAACGGAA ACTGCCAGAA GCACTAGGAA GACAAT7CAT GTAGCCTCGC TCGGGGTrGG ACAAGGCTGT GCACTGGAAA GCTGAGACAT CAAAATGATG GTCAGAAAAT ATTGCAGTGG AACTAGAGAG TACTTGGCGT 77GTTGAGTG AACCCAGTFC A FrCAAGCAA CA=TGGAGA ACTGAAGAT7 CTIATAATr CCCTGGACAA ATGGGAAGAT GGCTGTGTIT TC'=GAATr TCAGCCCCCT CACTGATCAT GGCACTAATT AAAAGACTAA TTAATCAGAA CATrAGTrCC TGAGCACTGT T=ICTAACA CACAAAATAA A FfATGGTCC AAGGAAAGAT TFrCACGCAGT CTGAGGACAA CATATGGGTC ATGGATGTI7 ATAGATGGTG CCAAAAAGAA AGAAAAGAAA GCACCCCTAT AAAATIGTC TG=T1GCAG T"IGG= GTGTATGTr TTGCTACTGG AAATCAT7CT GTGCTGGCT TGGCTAGGAC AAGGCCAGTG CCTGATAGTA AAAACTGCTT GTT=CAATA TCCTGCrCT CACTIAAAG TGAATTAAAA TT7ACTGCFT ATATATG CAT CAATACTATC TCTGTAGCTG ACACCATGCT TGAAACAGTC TCATCACTGC TAATTATGAG CCA FICAGA AGACAGGTGT GATGAGAGTT TrACA17CAA ATCATGT7CT CATTAT7CTG CTICCGAAT 'TCTAATAT GATTC=ITA GATTAAGAAT TCTGTCTAT7 CCATGCTAAT GTCTACAAAG TITATCAGC ACATCACAGT TAAAAAAAAA CAGCAAAGAA T7CATr=~A ACACATATGA TCCI=CCCT GGCCAAACAT TAGTrC-1T AAATGAATCT CAAAGATACG AGGGTTGCTC ATCAAATCTG A TCrATAG TITAAAGTGGG TA'FrGG=Ir TI-I=CACT GTCCAAG IT GAAGATGGTr GTrCI=AAG AAAGTATAAA TCGAAGGATC TCAAGCTTrAC C17CACAAAC TGGGATrGC TGTGTCCACT GCCCTF7GAGT GGTGCAFCA ACCTGGGCTG GTCCCTGCAA CATGAAGCCT TCCTCACAGG TGAAGTrGCA GGATGAMTG AAGGTGAACT CTCCAGCAGG GGAATGGCTG CACCTCACAG AGCCAT7CTG AGGCTGGCGG ACGGCCCTGC ATGTCACAGC TGTAACAAAT ATACGCAflG ATATI7AGCAC GGCCTAGAAT TAGCTGCCC ATIrCCAGTA TGGGTTGAGA GAAAGAATGT TCACAGTAAG TCTCCATGTG GAACAACTCT AC=F1ACAC G~rGGCTTCT CGTrGTCCCA AT7CCCAGAT GAGGTACACT GAAGGCTCTG GGCTCCCATr AGT7CAAATC CT7CITCACA GTCAAATGTA CAGGTTGTGT TCCATGGGAA G=TCCAGGG T1TGGAAAC A'ITCCACGAA CCCATTGGCT GGA'IMGTCA CAGCATCACA CTCAACCACT GAGGATI=A AAGAGCACCA TGANFI=AC AGAAGAATGA TCT1TCACT TCCTATITGAG CTGGGTGCCT AACAGAGTGA GGAAGCTGCC TrCAAAGGGT AGATCCCAAA GTCCTATGTC AA'FrCTAGG GACATGCACA GCCAGAATAA AAGC=ITAT TC1T1TCAT GGATATTCTA TCTITCTGA 'TrCCA=TI GCCTATGCTG AGTGGTCTCT WO 00/09525 PCT/US99/1 7712 EPI-109 134 AATCTATGTT ATCATACG TGAGGTAAAA AMFAAAAAA AATAGAT7CC AGATTAGGAG 17ATGACTAG TACTGACATA CGTAGGCTAT TCA'IMA'I TAGCCCATCA GAGCCTGAAG AACTGA'II TCTITTIG GCCTCTGGTT CAGAAAGATA AAAITAAGAG AGAAAAAGAG ATACTAAGAC TGC-I7GACTA TCATGGTCTT AAGTTAGTCC CATGGC'ITGG AAAAGTTAAA CAGGGAAACA AGATGAGAAA TCCAflGAGA 'I7rCTAGAGC MArrGrTr TATGGTCTCC CTTACAAATC ACCAGAGCCT CAGAAACACC CA'1CAAGC ATAGAATAAA AAAACCTCTC TCAACCCAAG CAGGTACTGG G'ITGGCAATA TACATTGGCT GAGAGAACAA A'I1GTATITAA AAACAAAAAC AAAAAAAAAA =TICCCTGA AGTITGAAA ATGTAAGTI7G AATCAAAAAA CAGAAGCAAT GAGGGATGAG TTACAGAACG T7CTGTGCAT TCTCAGAGGG ATITACCATF7 GCAGGCTGGA ATAGGAGCAC TCCATTCTCC AGAGGACATA CACTGCATGG TCTCCATGCT G=rGGCAGG TAACCCCTAT CACAGCTGAT AGAGCAGGAA GAATFGTAGC TGAAG'IMCC CAGTGGGTGA CTGCAAACCA GG=~CCATG CTCAGGGGAT TCCAGGGCTG TACAG7TCAC AACTGAAAAA GAAACCCAAA TCAGT7CTGC TCATCTCTCA CC'=AACAG ATAAGAACAC TGGAAACTAG AACTACAGTT TGGITMT TTIAGT TTAAAAA'IT ATAAAA ITTC TAATGGAATT TGTAAAATTG ACTGTAAT7C TACCCCTIT C'TrATrCA AGAAAATGCT GATCCATAAC AACAACAACA AAAAAGCAGT GATGACAACC ATAAAAAAGA AATATrGAGT GATATGGGGA GAGTAGTGTA ATrGTGTI17A CCTCAAAACT GTrCAAAT-A TATGAACAAA CACAGCAAAC TrAGGTACCA CAACAAAT1T =rG'rrA= T CTCACAAC TGCTAAAAAT ACTACAGTAA G=rCCAACC AGGATGAGAA CCATrCACAA AGCTATATF17 CAAA 1TrAAG TACTAGAATA CATrACAAAT MrAAAACCC TAATG~rGCA CTGTCTACTA TAGTAGCCAC TATCTGTGTG GCTACTrCAAA =TAAA=~G AAYrCGTTGA AATCAAATAA CA'TAAAAT TCAGTrCCTC AGTGTCACCA GCCACA~IrrC AAGTACTCAA TAACCACATG TGGCTCATAG GTACACACTG GAAAACACAG CTATGGAACA MTCCATTAT CACAAAAGCT CTACTGCACA ACGCI'GTGCT AAGGAATCTT GGAGAGAAGC TCATCTAACT C1rCT]AATGT ACAAAT]TAG GAACTGAGAC C7CAMICAT TCAAGTGACT TGCTCCATGC TACACGGCTA GTCA17ACAG AGCCAGAGGC CAGAGCATGA ACCAAGATAC CCTGGACTCT GTAACTCACr CAMC-TrACT GCAACGTCTr GTTACCACCT AGATGAGGTG AGTACATGI1r CCTCGCAGGG ACACAGAA'Fr ACAGTT7A Fr GAATGTGTCC TGTGTGCCAG GCACCATGTA ACCATGAGCC TATGAAGT7C ACACTATrAT TATCCTCATT VIrACAATGAG AAAACTGACA TAGAGAGTTA AACTATCTIG TCAAGGTGCC AAAATAAATA ACTGGTGAAT CTAGGACTCA AACCCAGCAG GGTCTGAC'Fr CATAGTCTCA GCTCACGATC ACCATATGAC ACCATCTGCA CCAGGGAAGG GAAGGCATGC AGACCTGACT CTAATGCCAG CTAGGACGTG AGATGGTGCT ACCATCTCAA GTGAAGAAAG AGGCAAGAAC CAGACTrACT TGCTCACAC T-TGAGTCCAC TGAAGCCAGG GTCACA=TIG CAAGTGTAAT TATTGATGGT CTCTACACAT TCACCGTGGC CACTGCAGGA TGTATTGGTA CAGGCAGCTA CGGAAAATAC AAAGCATGAT GAGGAGGACT ATrACTGTGC TTATACTGAG TGCC1TGAT 'TTAGAATCA ACAGTGTGCA ACAGAGACAT CAGCAGTCCT ACAGAGTGCC ATAGA=i~A ACTGAAGTGT =I~ACAAAGT TCCAAATCTG AGITTCAGGC CCACCTATCC TAAACCITGA TGCTAATGTA TAGCTGTGGC TGGCACCTAC CGTAGAAAAT TFrAMCTTrC ACAAACTCTG AAGACAG~rC CCCTACCACA AATAAACAAG TAATTAAAAT ATGTATrGTG TGTGTGCATT =I~ATATGTA AAGAACTACA TATIGCCTA CAGTAT117AT ATATATIIA TATATATACA TACACACATA TATGTGTGTA TATGTGTGTA TGTATATATA TAAAATGTAT ATAAATGCTG TAGGCTATAT ATATATACAC ACACACATAT ATGTGTGTGT GTATATATGT GTGTGTGTGT ATATATATAC ATATCCACAT ATlCTGCCC ACATTCACAC AAAACAGCAA AAGAGAGAAA C'=AGCAGT TAAACAGAAT CTITGGAAC ATAAAATGAC CACAATAGAG AGCAG1TI= GCATGCTGTA AAM~GCCAA GATGCCCACA CACTGAAACT ACCTCCCACT GCTGCCGCAA ACTCCCTACC TGTGTAGCAT AGGGCAAGCT TCT7Cl7GCT GCACCTCTCA TCATrCCACA TGCCCACATC TITFCTCTC TTGATGTAGA TCTCCACGCA GTCCTCATCT TITGCCTAT TGT7GGGTTC ACCTGGAGCC CAGT1XT1rGG CT7CTTCTGT CAGAGGMrC TGGGTTCCTA CCCAGACCCA CACATTGTTG ACT=~CTGA T7CCAATCCA GTAATAACTr GGTGAATAGC TCAATATGGA GITrrAGGTAC TCAATCTCT CTGTT1G AATTGCAACC AGGTGTGTGT ACC'=GCTG ACAATAAGCA CTGGCCTCAT CATAAGTCAT AGCTrCCGTG GAGGTG~rGT AAGACCAGGC TCCACTCTCT TFAATGAGAA GCACTAGTGG GAGAAAAAGA AAAGAAATGG TAGAG'IMGG TACTG'FTGTG GITr1AACTCT GACAACTGTG CT1TAT7G TCTITATI= GGCAATGTIT GTGACATGGC CCAGACTIT CTCATCT!T CAAAAGTAAG AAGTACGTAT GAAGAAACAG CGACTTAT7G 'FrATCTCTT TTGTGACTGC CACCCACTAG GTACCITATC CACACTCACT CACAACATTA TAGTATACCC NFITGTAGT AGAATAATAA TCAGAATAAC TAAGC1TAT TGAGCACTTA GTATGCACCA AGAAGCACTG TATGAGGTAC TITTCCATGAA CCATGCTAT GAATCCTCAC AATGCATCTG GGAAATAGGT CAFTATGATC CACAC'=AC ACTTAAGGAA AGGGAGACAC CAAGAGGTAA AGTAAATGAC CCCAAGCCCA GGGAAGAACA CATTGCAGGT AGAGGTCAAG GATGCTGCCA GATATCCTGT GCAGGACAGC CCCAGACAAG CAAGGATA7 TCAGTCTGAA ATATCTATAG TGCGAGAATG AGAAATCrrG GTCTAATGGC ACTGACITAC CCAAAGTGAG AGCTGAGAGA AACTGTGAAG CAATCATGAC T7CAAGAGT CTIT7CACCC AAAGGITTFAG G=TGAAATA C1TCCTGGG GAGATAAAAC ACAAAATGAA 'ITAAAGAAGG AAATCGTGGG TAGCTAGTrA CAT7AUrCTA CCATGATGTr TAAGGCAGCA TCCTAAGA7T 7rGGGCAAAG GACACTAGTG CAATAATCT7 TATTrCAGAG n7~AATCAAA TAAATAAACA AATITAAGA C1TCATTAT ITFAGGTCAAA GAGAAAAGAC AGG=ITAGC TACAATACAA TAAGAGCTTG TACAGATGTG GTITIA77A GAAGGCC1T TGCATATCTG TGM~CATGG CCCGAGGCTG CCCT7ATAAA GCGTrCTGCA CT1TACCG'TT7 TGGGAAGCAG TrGPTCAAAC ACAGGATCTC TCAGGTGGGT ATCACTGCTG CCTCTGTCTC AGGTCAGTAT AGGAGTITG ATGTGAAGTC AGCCAAGAAC AGCTGAACAC TAC'ITCGGCT GAGGCCCTI TATAGGAGGG AITGCTrCCT GTGAATAATA GGAGGATATT GTCCACATCC AGTAAAGAGG AAATCCCCAA TGGCATCCAA AAACTFCCC GGGAATATCC ACGATGCTTA AAATI7ACAAT GATGTCAGAA ACTCTGTCTC TrGAAGCTAC TTCACC'=G TCCATGCCT7 TATATCGTAT ATGCAATI= A'FrAATATGA CAAAAATGCA TGA'TITIAA 'TrATAATAAC ATAAAGTCTA TGTCTTAAA AAGT7GTAAA A='IGCTTG TFAGTAGTGT CTCTCATGTA GT7GTGGTAG TAAT7AGAAT 'FrCAGAAACA GAAGGAAACC AAGAATAGGT TTGTCATCCA TAGTCTACTA C=TCAA71-r CTCAT7CATA GCTGTGGATA ACCAATCACT ACTCA TI1 TcTrCCTIT TCACCTGCCA A7rCAACATA T1TAACATGC ACTGTCTCAC AGAGGAATGA CTCACAAGGT AGATATTAAT CT7CAGATI TGCACGGCAG 'FrATGCCTA.A ATTAAAATAT TATCTAAAAA TAATATCTAA CACTCAAATG GTTAAAATAA TGCC'ITATIT TAAAAAAAGA AAAATGGGAA ATAGATATr ACATCTGGGA AAGTI7CATG GMIG7FCAG TGAAAAAAAT AAAAAGGAGG CCAGGCACAG TGGCTCACGC CTGTAATCCC ACCACTTGG GAGGCCGAGG CAGGCGGATC ACCTGAGGCC GGGAGT7CAA GACCAGCCTG ACCAACATGG AGAAACGCCA TCTCTACTAA AAATACAAAA T7AGCTGGGC ATGGTGGCGC ATGCCTGTAA TCCCAGCTAC TCGGGAGGCT GAGGCAGGAG AATCGCTGA ACCCGGGAAG TGGAGG7FGC AGTGAGCCAA GATCACGCCA GTGCACTCCA GCCTGGGAAA CGAGTGAAAC TCTGTCI7AA AAAAAAAAAA AAAAAAAGAA AAGAAAAGAA AAAAAATAAA ACGGAAAACT ATATATATAT ATJT7AATTGG TCAAAAT1T GrrrAAAATr TIGAAATGT TAATGTGCAA AGAATAAAAA 'T=CCACA ATGT7AACAG TGACTAACTC TGGATGGCAG GATTGGGAT AKTI=ATA TC=TCATTA TTATI=CAG GN1TFAAAG TITFITCAA =I]CCCfl= n7~CAC=i~ ATAGTAACAA GAATACAGTr TAAAGAAACT TGTCTCTAGG CCAGGCATGA TGGCTCATGC CTGTAATCCC AGCACTTGG GAGGCTGAGG TGGGTGGATC ACCTGAGGTC AGGAGTTCCA WO 00/09525 PCT/US99/17712 EPI-109 135 GACCAGCGTG GCCAATATGG TGAAACCCTG TCTCTACTAA AAATACAAAA ATTAGCCGGG GTGTAGTGGC GCATGCCTGT AATCCCAGCT ACTGGGGAGC CTGATGCAAG AGAATCGCTT GAACCCAGGA GGCAGAGGTT GCAGTGAGCT GAAATCACAC CATrGCACTC CAGCCTGGGC GACAGAGCAA GACTCCATCT CAAAAAAAAA GAAAAAAAGA AAAAGAAAAG AAAAGAAATT TGTTTCCAAA TGCAACAGAA GGAGATGTAT GTGGTATCCT ATATTCCTGC TCTTCAT=TT GACATTCTT CTGGGTGATT GTATACATTC CCCATCTCTG CATCTTACCC TATCTAAATG ATGGTAACAG TAAATGGGGA TCATTAAT TTCCATATrC TGTAGG7TT CAGAGCTCAA GTCAAGCTAA TATTCTATAT CTACAGCCTT TCAAAATAGG AGGTCTATCT AAAAATGTAC TGTCAGCAGA CCTGAACGAG TAGTGGTAAA AGCCTCGTT TTCCTTAC TTGTTAGCAC TGGTCTCT GTGTTCATAA AGATGTCAAG ACCCAAAAAA AAAACAAGAA AAGAGAAGAA AAA7TCCAAA AAAGACAACT GATTAGAAAA AAATAACTTA ATrAACGAAT TTAATTCAAC CCCTATCAAA AAGCATAGAA TTTATTCCCT CCACCTTACC ACTCTCTTAC ATGATCCAGA TACTGACATr ATTCCAATTC TATCCCAC TTACTTAGC TCAATGTGGT TGTrGCTTCA ATAAATTCAG AAGAGTAATC ACTCATATAG TGTTATTTA GAT1TTAGGG CAGAATGTCA AGTrGGGTTA ATACATTATC TGTATGTATr TTAT1Ti-AA TAAAGTATGA ATACATAATC TGCTA-ITr AAAAAGCATG GTCAAATGTA TAGAGTAGCC AAATCTTAAA AAACAATTTA TCTTCGATAT CAATAAAGTA CCTAATAATT ATATTGCTAA TAGAAATTAG TCGTrAACAT CCCTAGATAA CTAACTTTAT TATrGCGAAT TTCATAAC TAAGTTTATA GTATCTCT TCCCCTT AAAATTAGTT CAAAGATATC TAAAAATAGC CCCAGTGGTG ATGAAGTTTC TATTTTACTT ACATATATAT GTCCTGGACC CCCAATTATA ATCTCTAACA TTTATTGAGT GCTrACTATG TGCCAGGCCA TATrCTGAGC ATTTGTATG TTCACCTATT GATTATTCAA TCCGTACAAC AGCCTATGAA ATAGGTACTC CTATTATCCC CATITTACAG ATGAGGAAAT TGAGAATCTG GGGAT=TTAT CTCATTCAAA AGCACAGAGC TAAGGGTTGA AACCAGGCAG TTGATATCCA GAGCCCACTC CCTTACCTGC TACTCCAAAC CATGATTTCT TTGITGTTTA TGCCCCGAGA TTCCTTGTTC TACCCAAGTT TCCTGTACTC TTCTrGCCCT CTTCTTCCTG AGACATCCTT GACCATCACA GCTCTCCACT GAGATAACTG TGTCCTGGGT TCTGAGACAT GGGGGCTGGA AGGGACCCCA GGGACAGTGA GCAGTAGGGA GAGGATGCAG TGAGAACAGA CCCTGGATCC CCGGTGCATA GGCAGGGAGA AAGTGGACAA AGGAAAAAAC AAGCAAGGCA GGTGGAGCCA TGCCTAGGTA AAGTTGATCC CTAAGCCACA GTTCCCAGAA GTTCCTGATT CAAAAGCAAA TTCTCTAA GGTCAAAGGG CAAACTGATT ATTCTAAATT CTAAACTGAT TATTrCTAAA TTGAGAAAGC TTCAGGGAGA GATCCCAATA TTCGAAGGAT AAGAGAAATG AGGAGTGGAA GAGATAGGTG AGTAACAGTA ACTTAAATGT AGACTATATA TAATATATAA TATATGTAGA GTATATATAT ATAATTACAA TATATTATAT ATGTGGAATA TATATATTAT TTATATATAT TTATATATTT TATATATATA GATATITTA TATTI'TATAT ATAAATATAG ATATIllAT ATTTATATA TAAATATAGA TA'ITT-ATA TATATrATAT ATAAATATAT GTAAAATACT GTGAAAGAAG AATAGAATCT TGAGACCTCA AATTCACTAT GCCAAAGGGA AAGTTAAGCT TGGGAAATGA GTCATGCAAA AACTGCCTTC CTTTGTTCC CAAATACCTG TAAMTTCACA TGCTTACTTT ATCTTATATA AAATGTAGAT GTACTGAGCA TGAGATCCAT GCATAATTC CCTCTAGTCC CTrTTrA CATGTAAAGT GTAGACTCAC TGAGTGTTAC AGAGCCTTGC CACAATGTAA ACAC1TGTCT CATrGCCAAC CCATCTCG TTATlCT TCCCCTCCTG CTTGCTCTTT CCCCTCTAAA GATGGAAGTT CCCAAAACTC TCTTTGGAAA AAGCGCAGGT CACAGATCCT ACAGTGATTT GTGTTTCTTT TACCTGGGAC AAAATAAACC TCTAATCTGT TGAGATATGC TFCAGTTACT TGGTTTA CAATATGTAC ATGTATGTAT ATAATTTATA TGTATATAAT ATATGTACTT GTAACCA GAGGTATGTT ATTCAAAATC CATTCATCCT TACAATTACC TGCATTCTCC CACAGTATTT TCTGTGTCCC TGCCCCCGAG GTTGTCACTG CAAATCAGGT ACATGGATAC TGGGAGCTGA TGGGCTCCCC TCTGGCTACC TGGGCTGCTG AAGGGGCCAT AGACAGACCC AGCTCCTC TCGTGGAGAG GCCCTGGGCC AGCGCTGCGT GGGAGTGGGA TTACAACCAG ACTATAGCTT CTTCACCTGC TITICCTAT CAGGATTTCA TAAGAGGCAA TTGCTTGTTT TTTGAGGGTG GGGGCAAATC AGGGGGAGTT GAAGAGGAAA TTGGGTAAGA TTrGAATAGT TGGGCATGTT GAATATTATG AATATCATCT CCCTCTTCAA ATAATCCAAA ATATACCCCC AAGAAACAGG CTGATTAGAG GTGCTTCAAG GCTCCACTGA ATCTCCCAAG CTCTGAAGAT GTAGCTAGCT GTTACCGGAT TGCCGGITI CAAGCCTCGC CTCACATGGA CCCTCTTGGC AGTTTCTCGC ATGGGGGAAG CATCCGCTAC ATAGATGGGA ATGAAAAGAG GAAAGAAGAC GGTGCAAACT CAGGCACACC CCGGTGTCTG CCACCAGTGC TA1TTAATCT CTGAGGTGTC ACCCTTCCTG GCTATTGT CTCTTCCTGG AAGTCTCTTG TCCTCTCCTC CACACCCTTf AATCAGGCAT CAAAGACTTT AACCAGTTT GCTGTGTGCC CAGGCCCACT CATTCTCACT TTATGGCAA AGGGAGTGGG AGACAGAGAG ATAGCCAGAA AGAAGAGATT GGGGACCCCA AGACAAATGT TAGAATTTA ACCAAGGCCA CCCTGTGGAC AGGAGATTAT TGGGMAGT GGAAAGCAGC ACTGGCCACA ACCACACGTG GCAAAAGCAT CTATCGAGGA GTGAAGTTAT ATTTGGTGAA TGTGACCGGG AAGCAGGGGC AGTGGTGTCC TCCTGCCTTC CTGAGGCACT CTGTTCCCTr ACCTCTGCGA AGGCTTATT TACCCCTGAG TGCTAG'TT TGAAAGCCTT AGTTCCCTCT CTCCCATAAA AAAGCTCTAC TCTGCTAACA TCTAAGTTAC CTTGCAGAG TCTTAGGTAG AGGGAGGAAA TCCCAATAAA GATTCCACCC TATCTGCAAA ATACAAACAT GGTATTrCTT GCATTCCCAA AATrGTGAAA GAAAATGTGT ATCACCACAG TAGAGAATGG CA1T1T1GT TTGATCAAAA CCTAAATATA TTGATGAAA ATGTGTCTGG TTCTAAGTTT ATITCCCAGA AAGCCATGTT TACTCACTTG GAATTTATAG ACATCTTATA ATATCTGAGT CGAGTAGGAG CTCCGGGCTC TACCTCACTC TTCTCCCA CACCCAGGGG GAAGTGTAGG GTrCTCAGAC TrAGAATAA AGAGGAATCA CCTGGACAAC TCACCTAAAA TGCACATCTT CAGGTCTCAT ACTCAGAGGC TCTGACTCAA CAGGTCTGGG TGGCGCCCAA GAATGGGC TTTAAATGAG TATCTCAGAT GATTCTAATA CAGAATGTGT AAGATGACCA GATCCTATCA CACTTAGATG TATTGGCCTA GGGCCACCTA ACTTGGAGAA AATGTTAGTA AGACCCCGTG GTTGGTGCTC AGCTATAGGT ACCAGAAIT TGATCAAAAT TTACTATCAT TGTGACACTT CTCTTCGGAA CTGGAAGGCC AGAACCCCAC TTGTAAAGTG CTGGGAAAAT ACAAGGAAAA TTTAGGGTGA GTAGCATT GAATTCTTAC ACATGGAAAG TAAATGTATA AGAATTCTTA CCAATAAAAA AAAAGCAAGA GAGAATAGCT GCTAAAGAAT TAACACAAAT ATGTATATAT TAGTTATTCT CITITCTCCT CTGATTCCAG AGGACTGT AATTCCACTA ATCTTCTTG AGCTTCCAGG ATGATCTGAG ACT7GAATTT TTCATGTGCT TTTGCrCC TATGGCAG CATCTTATCT TGAAGTTrCC GCTTCTGCT TGGGGACCTA AAAACTAACT AATGGGAATT TCTTCAAAAT GAGCAAACTC TGGTGAATTC CCAAAGCGGA AGAAACAAGT GAGGATCGGG CTGGTTAATT AAGAGAACT'r TTCCTGAATG TAGCCAGACT GTGCCGAC TGTTGTTAAC ATGAGGGAAG AAATACCCCT GGATTAGA AGAGCCCCTr GTTTGTTC CTTGGCCATT TGTGCTGCTT GTGTAAG TCAGAAATTT CCTGAAGGAC TATTATTAGC TTTGTTCTCA CGTCAGAAAA CTTCTGCTCT GGCCACTTTT AAACATATAA CTTGGATT ACTGTATTAG AAAATGTAAC AATTACAGAC AGCACTAAAA GGACACCAAA GGGCAAAGAA AATGGGTAAC T11TTCT TCCCCAAATC TAAAATAGGT GATITGGAG AAGTAGGAGA AAAACCTGGA TCTAGAT CTCTAGAG CTCAACAACT GATATAGTTA ATTATGTAAG TCTGATAT TTGGAAATGA TTGGATTAAC CGGATAACAA TGAATATTA AATACAGTGA TTTGGCCAGG AGCAGTGGCT CATGCCTGTA ATCCCAGCAT TTGGGGAGGC TGAGGCGGGT GGATCACCTA AGGCCGGGAG TTCCAGACCA GCCTGGCCAA CATGGTGAAA CCCCATCTCT ACTAAAAATA CAAAATTAGC CAGGCGTGGT GGTGCAAGAC TGTAATCCCA GCAACTCGGG AGGCTGAGGC AGGAGAATTG CTTGAACCCG GGAGGCAGAG GTTGCAGTGA GCCAAGATCA CGCCATrGCA CTCCAGCCTG WO 00/09525 PCT/US99/1 7712 EPI-1 09 136 GGCAACAAGA GCGAAA'I7CC ATCTCAATAA ATAAATAAAT AAATACAGTG ATTAACACA AGAGAMCT ATrCACACT AATGAGCTCT GTCACTGGGG CAAGC TCTT TGCCTCA FrA AGTCTCAGAT ITrCCCGAGAG CrrTAAFr TATACCAAGA GTGCTIACT ACCGTCTCTG CTAGCTGTGA CATAATATGA CAAAAGGTAT AAATATGGGA AAAGGCACTrA AMrATATCA AAGCGTTCTTr CG7TfICCT TGCTGTGAAG TITIAGCTA ATAATrCATA AGAATATACC ATAMTAGAG TGTJTACTAT GCATGGGCCT GGCACTrCAC ATACATTGCT TCTrACAAAT ,1TACAAAGT GAAAGGTAGA TA ITAATCTC KITIATGGA GGACAAGATA GAGATCTGGA GAGGTFACAT AACrTGCCAG TG 1TT=CA GTrAATAAAT GGTAGGGTGG AGATrCAATC TGTGT-FACTC TAA.AGTCCGT GTCC'T]TA Tr1GGCTCCAT GCCTACTCAG A'ITAAATCT CAGCAGGGAA GTAAACCITA GTrACAT GAGAAAATGT TACAGCAGCC 7rCTCGGCrr CCT17ACCCC CATCCCAG'IT TCACGAGCJTr AGTGCCIAG ATCGGGTTCC TrTAGAAGCA GACCTCGAAA TAAGGATGTG GGTGCCAGTC A'ITTAT1TGAA AAGATGATCC CAAGAAAGCC TAGTAGGAGA GTGAGGAAGT GAGATGGGGA AAGGAAGAAA CTCCACAAGA AGTGTGTrAA TAAGCAGGTr ACCGCTGTGG GCAGCCATGG GGCTCAGCTG CACTAACAAA CTCTGTCTAG TACAGAAAAC CTCAGGGTCT CCCCAAGGAG GGGCAAGAAG TCTGCCTAGG GTATATATCC GCCAACTCAG TCACTGGCTG AGAGCTGATC CTGGGAGGGC ATGGTTAA'IT CCTCTGCACT TrCAAGTGGA TrCCTGTGGT CAGAAAAAGC CCTCTACAAT GAATTCCAGA TGCTGTATr TAAATCrGAC ATGATOrGAA TGCTGTGrrG GGACAGGGTG GGCGrrATrA GTITCTGTC AT[ACTGTAA CAGAT-rACTA CAAACCTGAT GGCTGCAAAC AACACATATT TATTATGTCA TAGTTrGTGT GGGTCAGAAG TACAGGTTAG CTCAACTAGT TrCTCTGCTC TAGG 1TCAC ATTGCCAATA TCAAGGTGTC ATCCAGTTGG GCTCT=TG GGAGGCTFGG GGATGAATCC ACI=CAAGC TCATTCAGAT TGTrGGCAGA ATCCAGTrCC 'ITGTGGrrGC AGGACCAAGG TCCCTGTTGC CTIGCTGGCT GTTGGCCAGG AGTCAT7CTT AGCAGA GACTACCTGT ACTCTrCTGAC TCGTGTCTCC A=TCACCT TCAAACCAGC AGCGGCTAGT CGAGTCCCTC TCTrCAAATG TCTCCAACTG TGCCTTCACC TCATrCTCC TCTGTGTACC ATGTCTGCCT CTACTGCT7G TAAGGGC7CA TGGGATFACA TrGGA=~AT TCAATCCAGG ATAATCTCCA TATI=AAGG CTAGCTGACT AGTGATCTrTA ATrCCATCTrA CAAAGTCCCT TCCAATAGTA CTGTATTAGT CCA=fICAT GCTACTGATA AAGACATACC CAAGACTGGG CAATrCACAA AAGAAAGAGG 'IMAATrAGA 'TrTACAGTTC CACATGGCTG GGGAAGCCTC ACAATCATGG CAGAAGTCAA GGAAGAGCAA GTCATGT=T ACATAGATGG CAGCAGGCAA AGAGAGAGAG =TGTGCAGG GAACTCCTCT =F~AAAACC ATCAGATCTC ATAATACT'rA TFICACTATCA CAAGAACAGC ATGGGAAAGT CTIGCCCCCA TGATT7CAA17 ACTCCCACCA GGTCCCTCCC ACAACATGCA GGAATTCAAG ATGAGAT1TG TGTGGGGACA CAGCCAAACC ATATCAAGTA CCTAGArrCA TGTrrGA'rrA AACAACCAGG GAGCAGAAAT CTI7CAGGAGT GGGGGGCATC 'IMAGAATrC TGCCCACCAA GGCTGGGCGC GGTGGCTCAC ACCTGTAATC CCAGCACI= GGGAGGCCAA GGTGGGTGGA TCATGAGGTC AAGAGATCGA GACCACCCTG GCCATGGTGA AACCCCA'TTr CTACTAAAAA TACAAAAATT AGCCAGGTAT GGTGGTGGGC ACCTGTAGTC CCAGCTACTC AGGAGGCTGA GGTAGGAGAA TCACT7GAAC CCAGGAAGCG GAGGTTGCAG TGAGCCAAGA TrGCGCCGCT GCACTCCAGC CTGGGAGACA GAGCAAGACT GTCTCAAAAA AAAAGAATrC TGCCCATCAT AGTAGGCTGT CCTACAGAGA CATAACCCAG GAATrAGGTG AATGGCTAAC CTAAATrFAGC ACTGTGATGT GTITGAC TGGTCCITA TAG CTCCTCT GC'rTAGATGT GGAACTAATC CATGAATGCA AGGGMIGTC TAGAGTI=A AGTGGGAGTr AAATATCCAA AGTACAGGAG ATATTATGGG TGCCTCATCC ATGTCCCCT GGCATIATC '1TrrGGAT AACCCAACTC TATFrAG=II TATATCTCAC TFrGTrCCTAT ACrT1GTGAA CTGATGTCCC ATAAATAGAC ATTCA=Ir GCCAGTCFFC TGAACAATA ATTACGATFA 'ITAATCTAGC AGTWATCATT AAT7GGCCAC TrCACATrAG ACACAGCACT TAGGACTrAA GAATACCATG TCATrGATC ATCATAATAT GGTCAGGAAT TAAGTATTGC TATCCAAAT7 TrACAAAGAA GGCACTGAGG G FrAGAGM~ AAATAACUTG CTTAAGATGT CATAGCCrGT AAGTGACAAA ACTAGGACTC AAATACAGGT CCATCTGACT CCAAAGTCTA TG TCTrGGC TACCACACTG CCTCTCCTAC AAGTGACCTG TGGT1TACT ACTATATTCA CACTCTACTA AC1TACCAT CTCCCATGAG TCTGTCTAGA GGAGGGCACA CACAGCACAG AAAACACATG AATGCAAAAT AAGGAAGGGC CTACTACTA CACAGAGCCA TrCTAATACC TGATG'ITrGC TCTAATCCAG 7I=ACTATr AATTAG F7GC TGGTGCCCAA GT1TACTG AGAAATGGGG ATAATITGG AAGTCATAAT GATGCCTFCT TCTCATAGGG TATI=AMI GTTGITGTAT CTCCAGGCCC CAACACAGCC TGGCT1TAG TAAATGATCA AAAATACCTG 17GAATGAAT AAATGGAGTC ACCTGAAACA TGTrAAACAT 'TG'TCATGT GTCCTAATCG TGGAIT17CAG GATAGTAAGC ATCCTAAAAG GAAAGCATGC ACACTGT7CT TGCTACATTA A TCTCACA ATATAAAAAA AGAAAAGCAT CTGAAAAAAG CTGCCAGCCG CTGTGTCTCC TAATATCAAA CTGAGCACAG ATATGGAGAA GCTAAGGGAG AGGGATGATG GGCCATGCCT CTAACCrCAT CATGGCAAAA GTCCTGGGGG TCAGACCCGA GGAGAGCAGG AAGTGTCI= TGAGGGATAC A T7CCACAG TGGAAATAAT GAGAC1TAAA TAAATATTAT ATACACAGTr CAACTG=IT TATGTGTAAA GGTAGTAGGT TTrCACAGTA AGGAAGCACT TCTmr= '1TrGITGAG ACAGAGTCTC GCTCTGTCTC CCAGCCTGGA GTACAGTGGT GCTATCTCGG CCACTGCAA TCTCTGCCTC CTGGATTCAA GTGAT7CTCC TGCCTCAGCC TCCCGAGTAG CTGGGACAAC AGGTGTGTGC CAT-rACACCT GGCTAAITI TGTA'TI=A GCAGAGATGC GG71TFCACCA TGTrGGCCAG GcTGATCTCG AACTCCTGAC CTCAGGTGT7 CTGCCCGCCT CTGCCTCCCA ATGTGCTGGG A'ITACAGGCA TGAGCCACTG CACTCACCAA GCACTT7CTAC TGATAGCATr TACAAACCCT TC'I7AGAATA 1T7AAAAATr CTAAGAGAAG AGTAAAT7GA GCCTFCCCAA CTAATACTAG GAGGTTATAA CCT-rCATACC AAAACrGGAC AATGCTTGCA CAAAAGAAGG AAGCCAATGA GGCCACCTAG AAGGAAGACT GGGCATTGGG CCCAGTGAGT CCTGGAAACC TCATCTGTGC CAGCCACCCC GGCATGGCCT GTATGAGTGG ATGAGGGTGA CTTGTCCACA GACAATAGCC ATCTAGCTGT GATAAAGGAG TCAAGGTAGT CAGCTGCATC Tc=rCACcr GTrGCCAAT GTTACACAGG TTGAAAAGCT AAGGT17ATG TAAAGCAAGC ATCAAAGATG ATGAAATGAT CAACCTGACA ATGAGTACTA TGCTGCATrG TCCAGAAAGG AACTGTGGAA GATITGGGC TGAA'ITrCAA AACAGAMTT CCTCACTCTC TGGATG'TGG C77AcI=GGC CI=GATGTr CAGAGGTGGT GCCTIGTGT TGT7GAACAA TG~rGATIT GGAGAGAAAA CAGAGT7GAA. AAACCCACAA GTCATrCCCT GGGGAGTA IT ACCGGAATAC AGAGGATAAT ITCAGCAAGC CAGCAAGGCC TCATCTCTGC T7CTAATAGA TAGGAAGAAA GGAAGAGAGG AACAATACTT 1TrAAGAAG CTCAGCTIA TCGCC717ATC TCATAGAAAG ATGCCTCCAG TCTGTCTGGC TAAAGGTAAT TGGCATGGGA AAGTCITAT CrGTGATI7CT AACAAGTGGA ATGMTCCCT TCATTAAGAG AGCCTTGTCT GGCrGGGGA AATGAAACAC '1CTCCGAT ATGAGTGGGC TGTAACCCCTr GCTACTAAAT ACrCAGAAGA AATAAGGCGG TTGTGGAGCA GTCAGGAATG AGTCAC17GC CTCCc7GGAA TATTCAGAAA ACTGAATCAA AAGTACA ITC TTCTGGG Ff TCTAGTCTA ATAGACTAAG GGTCTCTACT TTG1TAAAT7 TCTGGGAAAC AGCATAGAAT GGGAGAAAAA ACTGGTCACT GTAGTCATGC AAATCTGCAA AACAAACAAA AAAGTCTGGG TAT7GCTGCT AACTAGCTAT GTGACCTTAA GCAAGGTAT7 AACTCrCTCT GAATITCAGG TTC'ITCATCT GTrAAATAGC ATATCTGTAA AATGGGAA F7 ATTCATAT CATAATGCTG TAGC1TIfIAAA AAATAAAATA AAATGGATGA GATAATCAGA ATTAAAGAGC CTGGGATATA TAGTrAATAT ATAGCAGCAT GTAAAGATCC TGrrAGAAAT GCTAArI=A CAGrrAACCA ITrGGAGATG ATrCCGCCAAA GCTGCTAGTG TAGAGGCAAC TGAGAAMG CCTGTCC'FC AGAATATGAA TAAATAACTG TCAATGATGT CTCAAGCCTA GAAAAACCTA TCCATCTGGA TGGGTGGc3AA ATITCTAGGC TAGTA~rGAG AAGCCCA IM =~GGGAAAT WO 00/09525 PCT/US99/1 7712 EPI-109 137 AGGTCCTGGA CTGAGTGAAG GAAAAGAAAC AGTAAAACCC ATGGTAAAGC AGCAAGGCTC TCTAGAGGCT CTGGAGAGGA TGAATTGAAT TCTAGAAGAT GAAGTAGGGA AGACGCT=A C=TC=GTG AAATGGATrC AAAGATTCAA AGACCTTCGG GAATCTCCAA TrGTATAAAT GGCACCATAG CTGTATGTrC CATGGAACAC TA=TCCCAG AGATGCCCAG TGAAAAAAGA ATGCCACAGT CAAATAAG~r TGGAAACACT CCATTATGTG GCCACCTCCT TGAAGACTCT AATGCACAT7 AQ~CATGTrAA ACAGTCTTGA GAAGTCCTGC AGAGCAGAAA 17G=TCACA TCTGCTAAGC CGGCAG I17C CCAATATACT TGAUTATGGA TAG1TI-hC =TACAACAC CATTCTCTGA TATGCTTCCA ATGACATGAA ATAAATATAT ATGCATGAGG 'FrCTrCATTA GGGCATAC'Tr 71-AATAGAA AATATTGAGA ATAATCTAAA TATAAATGCA CAGCATITAC CT=~CTGCA TAAACTATAT ACAGGCATAC CTTGGAGATA CTATGGGYIT GG'FrCCCACA ATATC1rCCAA AACCACATTC GG1TIATGA CCACTGCCAT AAAACCAGCC ACATGAAT1 =~GGMICC CAATGTATAT CAAAGTI7ACA 7fT=ACrAT ACCATAGTCT ATrATATATA CAATAGCA IT ATATCTAAAA AACAACGTAA ACACCTTAAT TrAAGGCTGT GGCTGGTT7G ATT=CTACC CAGACCACTA AAA==~CT CATATCAGCA ATAAGGCTGT TTCACITCT TACTA'Tr TGTGATAGCA CFTTCCT= CCTTCAAGAA 'TrCC=r CTATTCACAA 'IMG TT7GAT ACAAGAGGAC TAGATITAG CTrATCTCAG ITAAGGTGT rrACAUrGT7 AGCTAAAAAT GCTAATGATC ATCTGAGACT TCAGCAAGTC ATAATCTI= GCTGGTGGAA GGTCTrGCCT CAGTGTrGAT GTCTGCTGAC TGGGTGGC= TGGCAATTI'C 'PrAAAGTAAG ACAACAATCA AGT'17GACAT ATCAATTGAC CCT7CCTGTC ATAAATGATI' TITIT1TCT CTGTAGCCTG CAATGCTCT7 TGATAGCAT7 TTACCCACAG TAGAA'IrC AAAAT7GGAG TCAATCC1T CAAACTCTGG TGCTGT1TA TCAACTAAGT T7ATGGAGTA TTAGAAATCC C'ITTGTCA '1TCAACAAT GT7CACACCA TCTTCCCCAG GAGTATATTC TACCTCAAGA AACCA='TC 1GCTCATC TATAAGAAGC AGCTCCTCAT CCACTAAAGT 'IMATCCTGA GA~rGCAACA AT7CAG~rAC ATCTrCAGGC TCTAC'ITCTA ATTCTAG17C T='1GCTGTr TCTATCTCAT TrGTGCTTAC 'ITCTCCGCT GAAGT=~GA ACCCCT7AAA GTCACTCATG AGGGTTGGAA TCAACTrCT7 ACAAACTCCT GT7GATG FrG ATATITGAC CTGCTCCCAT GATTCATGGG TATrCTrAAT GGCATCTAGA ATGGTGAACG T1TCAGAAG GTITCAGTT GGCITGCCC GGATCCATCA GACGAATCCC TATCTATGGA AGCTATAGAT TTATAAAATG TA'IMCTI= TIGTGGGGG CATAGCGTCT CACCCTGTCA CCCAACCTGG AATGCAGTGG CACAGTCATA ACTCACTGAA GACTCAAACT CCTGGGCTCA AGTGATTCT CCACCTTGGC CTCCCAAAAC ACTGGATrAC AAGCTTGAGC CACTGTGTCT AGCCCAAAAT GTATATCATA ACTAATGAGG CTGAAAGTC AAAGTGACTC CTFGATCCAT GGGCTACAGA ATGGACGCTG GGTTACCAGA CATGAAAACA ATACTCATCT CCTCATACAT CTCCTICAGA GCTCCTGGGT GAGCAGGCCC ATTGTCAAAT GAGCAGTAGT ATC17GAAAG AAATTT= TCTGAGCAGT AGATCTCCAC AGTGGAC'ITA AAATAGTCAG TAAACTATGC TGTAAACAGA AGTGCTGTCA TCCAAGCTCT GTTCCAC TGATAGGGCA AAAGCAGAGT AGATrGGCA TAA'TCTCTA GGGCCT7AGG A'TI=GGAA TGGCAAAflG AGCA17GGCT TCAACnIITrmTITTr TTTGAG ACAGAGTCTr GGTCTGTCAC CCAGGCTGGA GTGCAGTGGT GCAATCTCGG CCCACTGCAA GCTCTGCCTC CTAGG'rTCAC ACCATrCTCC TGCCTCTGCC TCCTGAGTAG CTGGGACTAC AGGCACCCGC CACCATGCCC GGCTAAT1T ITGTATI=A GTACAGACGG GGTTICGCCA TGTrAGCCAG GATGGTCTCG ATCTCCTGAC CTCGTGATCC ACCCGCCTCG GCCTCCCAAA GTGCTGGGAT TACAGGCGTG AGCCACAGCG CCCAGCCTGT C1TCAAC=A AAGTCGCCAG CTGTG'ITAGC CTCTAATAAG AGAGTCTGCC TGTCC1r7CA AGCT1TGAAG CCAGGCATCA 'FrCTC=CTC TAGCTATGAA AATCMAGAT AGCATCTTCT CCCAATAGGA AGCCA7IIT TATGCCGTAA AAATCTGTCG I=GGTGTAG CCACCITCAT CATrGATCT7 ACCTAGATCC GCTGGATAAC 'TrACCACAGT GTCTACATCA 'ITACTTCTGC TrCACCITGC AC1T=ATGT TATGGGGATG GCTCC'=CC TCTAACCrCA TAAACTAACC TCCACTAGCC TCACATrCTT CTITACAGC 'TrCCTCGCCT CTCTCAGAGT TCACAGAATr GAAGAATGTf GGGC=~GGA TTACAC1TG G'TrrAAGGGA ATGC7GTGGC TGGTTTGATT 7rCrATCCAG AACACTAAAA C1TCTrCAT ATCAGCAATA AGACTGTrrC AcrrcrrC TATITITGT GATAGCAC~r 71'CC1TCCT TCAAGAAM TT rCUICrA T7CACAAT1T7 GACCGTrTGA TATGAGAGGC CTAGATTI7A GCCAATCTCA GiTIACACCA TGCCTITC ACTAAGCTTC ATCATITAG ClTI1TTrT AAAGTAAGAT GTGTGACCCT TCC1TCAT7 TGAACACTTA CATGATGATG CCTGGCI1TCA AAGCTrGAAA GGACAGGCAG ACTCTCT7AT TAGGGGCTAA CACAGCTGGC GACTI=AAG TFGAAGCCAA TGCTCAA1T GCCATTAGAA GCCATTGTAG GG~rAAT7AA TTTGCCTAAT TAATA17A TGGTGTCTCA GGGAATAAGG AGGCCTGAGT AGAGGGAGGG AGATGGGGAA ACAGCCAGTC ATCAGAGCAC ACACAACA'rr TATCAATTAA GT1TATCACC 'TTGAGGGCAC AGGTCATGAT ACrrCAAAAC AATI7ACAATA ATAAAATAAA AAATCA17GA TCGCAGATCA CCATAACAGA TATAATGATA ATGAAAAATT TGAAGTATTG TGAGAATTAC CAAAACGTGA CACACAGACA CAAAGTGAGC ACATGTCATT GGAAAAGTGG TGCTGATAGA CTFACrTCAT GCAGGGT7GC CACAAATACT CAATCTGTAA AAAATrCAAT TATCTACATA GTACCATAAA AACAAGGTAT ACCTGTF17AT ATAATCAAGA CCAACAGAAC CCTAGAGAAA ATAGCTCACT CCCTAGCTCG GAGACA'rCT AACCAACATA CACTTACCI7 TCTrI=GCT GTGTACAGAA 17CAAATCCC TGTCTCAGCA AAA'TrGCAAA GTATCAAATG TCATGTCCAT CTAATACTCA AAACTGCAAA TGTTAAGTCT TGTAAGCCCA GAGACCACTG TATATACAAG TGT17GCTATA AGCAT7AGTF CTTCTCCAAA GAAAATAGTC CA=~GGTAG AAACAAACAA AAAGAAAAAA AAAGAAAGAA AAAACA'ml TITACAAGAAG A'TCAGTCTC TrACCTACAT AAGCAAAAAT ATGAGATGIT CT=~ATCAT =ITCCATCT AT=TATAAT CT=GGTGCT GACTTAGACA CTCAT=CC T-1TGTACG TGACCATGTA AAAGTrCAAG TCAAGAAAAA CTTGTITGA CA'1G=Ir GCTrGAGTGAT GGGTCCCTAA AAGAAA'TT7G GCT=GC'= TGAAAAGTI7C AGCATGATAT TGTGTGAAYr 1TTCATGGCT AATGAT=IT AGAACAGTTG TGATGTGTT AGGTGT1TA AGAATATGAA GCATTCAGTG GT117AAGTTG GTTGTTATAA AATGAAAGAA TATGAAGGAA AGC==CTG TCTAGAACA CACTGATTCA CAAATAAGCA GCTI'CTCrCA AAATG77GTA A FrACAAAAA ITCCAAGGCA AATATAATAA ACTCCTTGTC GGTGCTATGT CTAGAAAC'T7 AACAGCCCCA AAGAAAGTCC TGACAAGGCA AAAAATATAT ATATATATAC AAA'ITGTGGA AGCAGGGTGT TGAAAGAAGA ATAAAGACTA TATAAGGACA AACrG'TnAA AAGGGAGGGT ATCCTIGAAA GCTGACACT TGACTCTIT GACGAGGCTG AGGGAAAACA CTCAGTICA TAGATrGCTG GTACGGATGT AAAATAGTGA CATCCCTATA GAGAGGAATT TGGCAATATC TAGCAAAAGT GC=ATGCAT TTATrT=G ACCTAGTAAT CCCGCTTCTA GGATTAGTGG TGAAGATACA CCTCAACAAT AAAAATATAT ATACATTAGG 'ITATrAGTrA TGGMTAA'17 'Ir7AATAGCA AAATATrAA AACAACCTAC ATGAACAAAT AGGAGACTTA CTGAATAAAC TATGGTATAT CTGTACAATA AAGTGCAAT7 CACTATGT7 G'ITAATGT TCCAAAAATC CAGAGCCAAA GAGTA'IMGT TATGCTCTCT TTAGTATAAG AAAGGGGAAA TAAGATATGT GTGCATCTGT T7ATT1TGT GAAAATAAGT ACAGAAAGGA TAAGTAAGAA ACTAGTAAAA CTAG FrATCT CCTAGTG FTA GTAGAAATAG AATGAAAGTG AATrAGG=r C'=GAGTAT ATGTTATAT ATAGTITGA CITFGAAT7 ATGT'17ATGT TTACATAGTC AAAAATATAA ATTAATCAAC AGAAATAACA AAAAAAGAAG AAATCACAAG C=hAAAA'T TAATACAAAC AGAAATAATT GAATCTAACA GTATATCAAA GTGATAACGT AAACTCAGAA GAAAAAAACA TAATCCAACA TACCAGTGGA ACACAATATT CTAACTGTAT ACATrCAGTG G17ATAGTCT AAGGACAAGA AAAATrGCAA AAATATCTTG AACT=AGCr TGTAGGAT~ 7rATTGGTAG CAATACTAAT GTACTAATrC TGAAATTAAT G7rCGTGTAT TATAGAAT17G AGTAAATGAA TAAATATGTr GATGTTATTG GGAACTAAAA WO 00/09525 PCTIUS99/17712 EPI-109 138 'FrATCATTCT GGGAGTAGAG AAATATAAAT ATGGACTrGG CAAATGAAAC AAAGACCrc3C AGAGAGATAA CCATATAAAC TCAT7ATIT AAAAATTATA AGTGTCCTAG CTCTGTrACT GAAAAGGCCT AGATrCAATC 'rrATCTTGAT AGACAGGAGG GCACCCCTF CTCAGAACAT GG'I=CCAAA TGCCA TCTC CATTAAAAGG AACAAGGTCT TCI17GGAGAA AAGACTGAT7 CTAGGTCTGG ATTAGGTAAA GTACAACGTT AGTCTGGAAT TrCT7GCTGA ATCAGAAGTA AGAAAGTGCT CAAAAACATG GGAACATGTC ACAAACACAC GTGAGGCAAC TrGAATCCTC ACrGGCCATA 'TT7AGGACAA TCGAGCATCA AAAAAAAAAA AAATGT7GAG AATAATGGAT TCTAACACTr AAAACAAAAA ATAATCCATA GCCCACAGAA GGGGAAGAGA GGGGGAGCTC TI7AMIACAG ATGAATATCA AATAGCAAAG ACAGAAGAAA TGACAGAATT AGAGAAACAT CATI=GCAA AACACCACTG TAATAATCAA TCAGGCAAG TA FTATrAAT GGATGTA'ITA CTATlGCGTA AAACCAGTrG GGGAACAGGA TATrCATACA GTCTGAAGGT GTCACCCTAA ACATAACTTA TTACAAGTGG AAAATGGTGC CT=ACAATG AAGAAATCTA GCAGAAACCA TCTTAATCTA GTGATCAAAC TrAGTATCAC CAATAATGGA TCATACTGAG TCATGTGTCT CCTAATATGA TGCACCAGGA AGGATGCAAC GTCATGAACG TTGTA17CTr 'TGTATrCAA CAGACCACCC AGGGTAAAGG CAGC=ICTC AC=ACTAAT CAGAA17GTTr GG'TrTAATT CA1TFGGAT TTTAAGATI C17AC1TCT TGTCAGCTCA GAAA ITTA F7 TAAGATGA FI MIATCI1T ATlCAATACTr 7rAGCTTGGA GAACCATTCA GAGMTCTAA CTCATTGTAT TGCCAAAAAT AGAAAACAGC ATGG'TrTCTr TTGAAAATGT CTAACTTAA AGTTACU7GT GTGTGTCACT CAGATTCACA TAG CITIT GCCTAGTAAT GTAGTATCAT GTGGCAAGGC TATAAAAATG =~ACAATCT 'ITATIAAT ATGACTCI1TG AGAGMT1'T CTAAGGAAAT AATT1GAATAG TAACAAAACA CTATTAACAC AAAGCATAGC AATTTGAT7 GGGCAACCAA ACACTGGAAA CAACCTAAAT GTCCATTACA GGAATCAT ATGAAGCAAA CACTAAAATA 'IMATrGTGA AGAFATGAG AACATAGAAG ACAGTrATGA GAGTAAATT GAAAACCrGA ACACAAAACT TACATATACT CCAATrGTAA CTrATAAAAA ATACGTGCAT ATAAGGATAA AACAGTACAA ACAAAAAAAT AGTrGCG'rrA GAT7GGTAGA ATTATGGCTC CTITGCTGT CTTAATIT TCCTF=ACA =IIGATACA T7ATITAAT 'FrAATT=A AAAT7CAAAA GAA'1TGCCA CTCAT='~G CCACTTCAAG GAAAAAAGAA ATGTGT'CGA 7rATrCrGIT =FAGTATAG =IrGGCAAT TrCCTCACGT GTAAAAAGAG AATACTATrA ATAA'ITCAG TATCTATAAG ACAATATAAA ATFTAAAGAAT CTAGCCCAGT AACrGGTACA TGGAACGTAA TrAATAAATC ATTATGGACT 'IIrTCTCA CACCCAAGTA GGGAGGAATC AGTGGTCCCC TAGAGGCCCA GTGTAGAGGT GGCAGCACCA ATCCCTAGGG GAGAAGATCT TGGTGATGAT AAT-rCCTGAG CAGACAG7rA GCTGAGAATT CAAGAGCAGA AAAGTAAGAA AGAAACAACT TC~rGCTAAC ACC1TCCAC CCACGTICC CTGT7CTGTFT GTACTCTGCT TACCCTTCA TGGATGGAGG CAGAGGAAAG AGAACCAAGT 7TGCTCTTAG TCA'TrCACTA TG'TGMrAA TCTGCCTTCC ATCII=T]A TCAG I1CAAA I1AGAATGTA GACCTGAATT TAAATCCCCG TTCTGTCAGT TATAATGTGA CCCTAGACAA AACACA FrCr CTGAACCTCA GAGAACATTC TrCATMGTA GAATGGGAAG ATFAATCTAT A FrCCACTTG GATGGCAAGT C7ITATAAA CTIATAACC TAAACATGTG TGAGT'rGCTA GTATCATTAT GTTGGTAAAG TFrATrCTGAG ATATGATAAC AGAACTG'I= TGTCTAACTC CACTAGCATG GTrCAGG'Tr AGAGAGTGTG GAATrAAAAG GCITTATCCT CAAATATGAC TrAAATCCGA TTITCTCAT CCA=CTI CCACAAACAA ATCCTCAGGA AATGACAAAC TTrACATGGT TAAACATCAG TI=GM~AG TC1TGACAT CCACATGGTr AAATCATACA TI7GAAAACT GCT7ATAMT GTGTTGTCTA TGTCTAAATr GAAAAGACTr ATTGAGGAAT AGAAGACTAC ACATFITCA GCAAACACTG CACG=FTGC AGAATrrCCC CAGGCACCAG TCTCCAGGAA 'I=AT-rGGCT ACTAACAATA CTAAGATATG GATGAATGAG GAAATCAAAA TGGAGATCTT GCAAG7I=G TGAGAATGGG TGAATGGTCC AAATGAAGAG ATAAG77GTG AAATATTAGT ACAAGTAAAA AT7AM~ACA ATGAAAGACA TITGTCAAT AGCTATGAGA ATITACCAT TGACCCAGAA ATrCCA'TrrC TPCTTCAGA AATACCCACG TAGGTATACA TATAAAAAGT TAflCATrAC AGTATCG Tff TrCATAGGAA AAAGTI=AA AAATCAGAAG CTATCTAAAC TATGGTATAT CTAGGTCATA GAAATCAAAT GACTAAAAAT GTTAATATAA GCATATGTI TrAAATTAAC 17GGCTTGGG T=~CAGCAA AATrGGCT7C 'FrAACATrGC ACTCCAGAGT TAGACTTACC CACTCAGTCA =TATCATGC AGGAGCAGAC TCCTAATACC ACATATCATA GAGCAGAGTA GGACACAGGT TCTCTGCAGG CAGGCAAATC CCAAAGAGAA GGGAGGAAAG GGCTGAGACA CTGCATGGTC AA'ITTCTrCT GAACTCTGCA ATGTACGGAG GTGGACAGTG TCCACAAAGA 'rrGCTCCCCT GGACCCACCA TCATAATAAC ACAACGGCTT TGIIGITT T7GTITGT ITITGACAC GGAG=~lGC TCTTGT7GTC CAGGCTGGAG TGCAATGGTG TGATCTCGAC TCACCACAAC CTCCACTTCC TGGGTTCAAG TGAT7CTCCT GCCTCAGCCT CCTGAGTGGA TGGGAITACA GGCATGCACC ACCATGCCCA GCTAATITG TA'TFIAGT AGAGACGAGG TFICTCCACG 'TTGGCCAGGC TGGTCTCAAA CTCTTAACCT CAGGTGATCC ACCCGTCTG GCCTCCCAAA GTGCTGCGAT TACAGGTGTG AGCCACCGCG CCCAGCCCAC AATGGCCT1 TG'IMACATC TCTAGTGCAG CACTCAITC ATGT~T=C AAGAAGAATA CATAM~CAT CTI=AM~ TATACAGCAA T7AGCACAGT GCCTGGCATA AGGAAAATGA TCATTAAAAG CTGGGTGAAA AACCTAATAA AGCTACTGAG GATAGGAACT GCAGACCAGC ATGGAAAGAA AACTATGAGC CAGATA'ITGA CATCATCCTG AAAGGCAGAA GA'FMAGTAT AGGCAAGAAG TATGC3T=G GAATATAGAA AATCTGGAT7 ATGATAAGAA AAGAATCATA TIT7GTCTAT CT7ACCTACT CA=TCTCAG T7CCACATGT TTCTGAGGCT GTITGTCCT7 A=C1TCF CTGTITATC CACTC1TCT GTFrC'IAGA T7GGATCATr CCTAUTGAGC TGACATCAAG TTAACTGACC 'mATITG TCCAAACTGC TGTrAAATGC ATCCAGTGAA TflTAACTr TATATAGTAT ATCTI=AGT CCTAGANT- CCACATGAGT TFITAAGT7 TCCATI1CTC TGCTGAGATC TCCTATTrGT TCATTCAT~rA TGACCATA'IT T=CTCTACA T7ATTGAGCA TAATTATAAC AGCTCITCTA AAATTCTTGT CTGCACATrC TAACACCTGA ATTATTCTGG GGTCAGTCTC TG7TACA FTG CCTrATrACA AAAACAGTAT AAGTCACA17 GCCrG'ITrC ITrAATATGCA AAATGATI= TGATrGCAGA cTAGACATr TGAATTAAAC ATTATAGAGA TrCTGGATTC TCGAGAGAGT A7FGA=~GT 7TT1CCATC AGGCAGGTAA CTIGACTGGA CTCAAACTCC AAACTCTAGG TCCTCTGTAA TGGGCAACTG CAGTAATCT7 TGT17AG'rrC 'IMAAGACTT ATTGGCCAGG CACGGGGGCT CATGCCTGCA ATCCCAGCAC TGTGGGAGGC CAAGGTGGGA GGATCACCTG AGGTCAGGAG TCGAGACCA GCCTGGCCCA CATGGTGAAA CCCTGCCTCT ACTAAAAATA CAAAAATTAG CCGGGTGTGG TGGTGGGCGC CTGTAGTCCC AGCTACTCAG AAGGCTAAGG CAGAAGAATC AC'ITGAACCT GGAAGGCAGA GGT7GCAGTG AGCCGAGAT7 GTGCCACTAT ACTCCAGCCT GGGTGACAAA AGCGAGACTC CCTCTCAAAA AAAAATITAT TGGCACTGCT TGGCATCTGC TATGAATACA TGAAGTTCAT GGGTCAGCTA TAGATCTGGG CACGT7ATAC ACAGAATITG GGTCTCCCT TCTCTGGATT TCTCCTTC TGGA'T7C'T rrCTCA=F~ CCAGCAGCTG TGGTI'GCCCT AAACTCGGTC CTCTG'1CT TACGGCAGT AAGATGGG AAC1TIAGG =I~ACCTGC CTCTCAGACA AAATAAAAAA TAATITCAT =TGATGCTA CTCCITC= CCAGATGTAG ACACCTCTCT AAM~CCAGT TGCrTrrAT TGCTCTCCAG AGTCTAAAGA T7ATCA TGT 'ITrCTGTGGG AGAGT7GGTC TGATAAAAAC TACTCCCCCA AAACTGGAAG CTGGAAGCT GTAATrATGA ATAGACITG AGTAGTAT7C 'vrCITrGGAA AAGGA=IIA ACTACrCCCT ATGTACICT TrAITrCCTG TITCTCAT CCGTAATCT 'IMA'r=CA TA=rCCTAA GTCAGACAAT 'FMCCTAC= GAAGATlCAG TGACTGCTAT CAAATGACCC CCATATrACT AAATACAATA TCCCCAACTG CAITTATAAA AAGAAAA'1 ACTGFITATT AGTAAACAAT GTrGTAGAAT AGTAAAATAT TGCTGGGC= TGGAGCCAGA TAATCAAGGT TAGAATCCCA GAITCTAACT TACTAGCTGG TGTAflAGTC WO 00/09525 PCTIUS99/1 7712 EPI-109 139 CTICTCATG CTGCTAATAA AGACATACCC CAGACTGGGA GACTGGGTAA TrATGAAGA AAAGAGGTr AATrGACTCA CAGT'FCAGCA TGGCTGGGGA GGCCTTAGGA AACTrACAGT CATGGTGGCA GCAAGGAGAA GTF1CCAAGCA AAGAGGGAAA AGCCCCTTAT AAAACCATCr GATCTTATGA GAACTCACTC ACTATCACGA GAACAGCATG AGGGTAACTG CCCTCACGT7 TAATrACCTI' CCACCAG~rC CCCCCCATGA CACATGGGGA TrATGAAAGC TATAATTCAA GATGAGA Tr GGG TGGAGAA ATAGCCAAAC CATATAA'rrC CACCCCTGGC CCCTCTrCAAA TCTCATGTCC TCACAnITCA AAACTCAATC ATGCCCTCCC AACTGTCCCC CAAGGTCTTA ACTCATrCCA GCATrAAGTC AAAAATCCAA GTTCAAAGTC TCATCTGAGA CAAGGCAAGT CCCT'rCTGCC TATGAGCCTA TAAAATCAAA AGCATGTrAG TTACITCCTA GATACAGTGG GGGTACAGGC GTrGGGTAAA TACACTGATTr CCAAATGGGA GAAATrGCCA AAACAAAAGA GTrACAGACC CCATGCAAGT CCAAAACCCA ATAGGGCAGT CATrAACAT7 AAAGTrCCAA AATGATCTCC 'IMGACTrCA TGTCTCACAT CCAGGTCACA CTGATGCAAG AGGTGGGCT7 CCAATGGCCT TGGGCAGCTC TGCCCCTGTG GC'=GCAGG GTATAGCCTG C ITCCTG1TT GCTIrTCAC AGGC1FGACAT TGAGTGTCTG TGGCTITCC ATGAGTATGG TGCAAGCTGT TGGTGGATIT ACCATTCTGG GGTCTGGGCC AGGTGCAGTG GCTCATGCCT GTAATCCCAG CACITGGGA GGCTGAGGTG GGGGATCACA AGGTCAGGAG ATCGAGACCA TCCTGGCTAA CACGGTAAAA CCCAGTCTCT GCITAAAAAA TACAAAAAAT TAGCCAGGCG TGGTGGTGGG TGCCTGTAGT CCCAGATACT TGGGAGGCTG AGGCAGGAGA ATGGCGTGAA CCCAGGAGGT GGAGCTTGCA GCGAGCTGAG AT~rGTGCCAC TGCACTCCAG CCTGGGCGAC AGAGCAAGAC TCCATCAAAA AAAAAAACAA AAAAACCATT CTGGGGTCTG GAGAATGGTA GCCcTrACAG CACCACCAGG CAGTGCCCCA GTGGGGACTC TGTGTGGGGG CTCTGACCCC ACA'I1CCCT TCTGCACGGC CCTAGTAGAG GTrCTCCATG AGGGITCTAC CCCTGCAGCA AA=TCTGCC TGGACATCCA GGCA'I=CCA TACATCCTCG GAAATCTAAG CCGCGGAGGT TCCCAAACT CAATrTrGA CTC~rGTGCA CCCACAGGCT CAATACCACA TGTAAGCCAC CAATGCTIGG TCAGGGC117G AACCCTCTGA AGCAATGGCC TGAGCTGTAC GTTGACACCT 'IMAGCCTAG ACATCTAGGA CACAGGGCAC CATGACCCGA AGCTCATAA AGTGGGAGGG CCTrGGGACT AGCTGAGGAA ACCATTIC CATCCTAGGC CTCCAGGCCT GTGATGGGAA GGGCAGCCAT GAAGGTGCCT GACATGCCCT GGAGACGT TCCCCATrGT CTTGGTAACT AACATTCAGC TCCGTGTGCA GCACCAACTT7 ACTTATGCAA A TTCTGTCA CTGGTIGAA =FCTCCCCA GAAAACAGGA TrC'I= CTA~rGCATC ATCATGCTGC AAAT1TCAA ACTITATGC TATGCTTCCT GFI7GAAGACT 7rGCGGCTA GAAA 1T7CT CCCCCAGATA CCCAAAATTA TCTCTCTCAA GTTCAAAGTr CCACAGATAT CTAGGGGACA AAATG F7GCC AGTCTCT=G CATAGCAAGA GTGACCTTA CTCCAGTrCC CAACAAGTTT CTCATCTCCA TATGAGACCA TCTCAGCTI'G GACTTAGTrG TCCATGTrfAC TATCAACA'FF TTGGTCAAAG CCATTCAACA AGTCTCTATG AAG'I7rCAAA CTCCCCATG 'IFICCTGTC 17CTAATAGC CCTCCAAA'FF MrCCAACCT CTGTCTG'FrA CCCAGT7CTA AAGTCACT-rC TACA7IT[G GGTATC1TA CAGCAGTGGC ACTCCCCATG GTACTAAT77 ACTGTATT1AG TCTGTTCTCA TGCTGCTAAT AAAGACTrAC TCGAGACTGG GTAA17TATA AAGAACAGAG GTrCAACTGG CTCACAGTFC AGCATGGCTG GGAGGCCrCA GGAAACTTAC AAACATGGTG GCAGCAAAGA GAAGT7CCAA GCAAAGAGGG AAAAGCCCCT TATAAAACCA TCAGATCTrG TGAGAATTCA CTATCATGAA AATAGCATGA GGGTAACTGC CCCCATGAT7 AAMTACCTC CCACAGGGTC CCTCCCATGA CAGGTGGGGA T'TATGGGAAC TACAATTCAA GATGAGAM~ GGGTGGGGAC ACAGCCATAC CATGCCAGCT AGAGAGCCTT AAGAAAGTCA CCTAATCTCC ACAAATAAAA GGMTCCTAT T7GTTCAACA AAAATAATGA CACCCCT1T ATGGGATrC TGTGAGGACA AATGATAACT AACATAGCCT TGCATAGTGT CTGGCACAAA ATAGCTACTC AAAAAATAAT AGAAACAACA TrAAAAAAT GTAGA='~A 'IIhAGAG 'F=ATGTAC AAAGCAAAAT TGAGCAGAAT GTACAGAGAG ITCCGTATA GCACTCCCTA CCCCCAAGCA CAGATAGCCT CCCCCAGTAT CAGCATCCCG CACCAGAGTG GTACA'Tr7AT TATAACTGAT GAATCTATAT TGACGTGTCA TI=CATCCA AAATCCATAG MTATA F7AG GGATGCCTCT TGGTGTTGTA CCTICTATGG GTI=GACAA ATGTATAATG ACATGTATTC ACCATrACAG TATCATAAAG AATAGTT7CA CTGTCCTAAA AAT='~GAT C=rCrA 'ITCATCACTC CCTCCCCATT AATCCCTGAC AACTACTGCT AA=TICCTG TCTCCA17GT TI-TGTCTI= CCTGAATGTC ATATAG'IMA AATATACAGT ATGTAGGA17 TTCAAACTGG TIT'TCAC FrAGTAATAT GCATrTGATG 7rCTrCCATA TC1TICAAA GCT7CATAGT TCAATAT17A TAGAATrGAA TAATATCCA TTrGTCTGGAT GTACTACAGT TATGTAFI7C ATTCACCTAT CAAAGAACAC CTGG~rGCT TCCAAGMVC AACAATCATG AGTAAAGCTG CTATAAACAT CTATGTACAT GTIT1T=GT GAATFGAACA rTTCAG=T T=AGCTCC A~rCCTAGGA GTGCAATTGC TGGATTGTAT GATAAGGGTA TGIT7AGTGT TGTAAGAAAC TGCCACGCTC rCCTAACTG GATGTACTGT MTGCA TCT CACCAGCAAT GAAAGAGT7C CTGTTGCTCC ACATACTCAC CAGCA'ITGG TGTCGTCAAT G=~GAGCA ATAGCA1T= GATCTAACTT 'FrCCTAGGTA 'TCTITIGA AGGAAATAAT ATGACAGATA ATAGAGAAAG GATATACGAG GACAGTTCTG TCC=hAM7~ ATAGTCCATC AMIIAATGAA GGACTCTGTC CACAC'ITGGT A'FI=AACT CTGATCCTCC TCTCCCATGA ACTCTGACAA TCTCCTAAAT CCCTGITrGCT GGCACACATG GTTGTGTATC AGGCCCCCTG TGGTCTGTCT GAAGCATGGC Trr~~rrr rMrl-TI= 'TFTrGAG ACGGAGTCTC GCTCTGTCGC CCAGGCTGGA GTGCAGTGGC GCGATCTCGG CTCACTGCAA GCTCCGCCTC CCGGGFI'CAC GCCATrCTCC TGCCTCAGCC TCCCGAGTAG CTGGGACTAC AGGCGCCCGC CACCACGCCT GGCTAATT 'TGTATIT AGTAGAGGCG GGGnI7CACT GTGTrAGCCA GGATGGTCTC GATCTCCTGA CCTTGTGATC CGCCCGCCTC TGCCTCCCAA AGTGCTGGGA T7ACAGGCGT GAGCCACCGC GCCCGGCC'IT 7Flm-rr'F ~fTTTf= TGAGATGG AGTc17GTCAC TCTGTCACCC AGGCTGGTGC AGTGATGCAA TCT7GGCTCA CTACAACCTC CATC1TCAG GTITCAAGTGA TlrcTGCCACC TCAGCCrCCC AAGTACCTGG GAT-fACAGGT GCCCGCCACC ACACCCAGCT A'mTITMGT ATITAGTA GAGACGTAGT TI1CACCATGT TGGCCAGGCT GGTCTCATTC CTGACCTrGA GTGATCCACC TGCC'IGGCC TCCCAAAGTG CTGGGAT7AC AGGCATGGGT CATCACATGT GGCCTGAAGC ATGACTGTTG Cr=AATCAT ATGAAATACT GCTCTrGTATT GTTATCTATT TGAAATGCCA CACCTCCTGA GCTAAA'ITGC AAGCTI=AT GGAGCACAAA CCATATI1AT ATATATTAGC ATGATACCAT GACACATATC AAAAGC7GT7 ATATATI'GT7 ACGTGAA1TG ATrCTTCTC AG FTAAGAGG ACCTCTGTAG TAGCACC ATACCGTrAA TITICATPT TGTGCCCAGC CCCTACTCTG TGAAAAATGA AATGAATCCT GflATCA7Tr CCCTCCCAGG CC'IrCTCC T7GTGGACAA TGTGTGGCTC AAGAGAAAAT TCAGTCAGTA AATGTTCA GTGCACAAAC TC1TATCAC CTCTCACTGT TCTCAAGTGA GATAGAACAG AACATCCATC CAGTGTCITA CAAATrGTCT GGTATATAGT AGGCACTCAA TAAATGTIT TrGAATAAAT GCATACATGA ATCCTAT7CC TATATATAGT ATGGTAGACA GATCATTGAT ACCCAAAGAT GCCCAAATGC TGATCCCCAG AA=TGTGAA TATGT7ACAT TrCATGTCAA AAGGGAC1T GCTAATGTGA TrAAGGATIC AGACCCT7GG A'TTGTAAGAT TATCCCGGAT TAACCAGGGC CAATCTAATC ACATGAGACC rrAAAAAAGC AGAAAACA F7 TCCCAGCTGG GTTAGAGAGA GATGAGACAG AGTAAAAAGG AAAGAGA'TFC AGGGCATGAA AATGAVITCTA CCCACTGTrG CTGGC'=GA AGATAGAGGA ACTAGGCCAC AAAACAAGGA GTATGAGTGG CCTrAAGAAA TAGGAAAAAG CCCTCATCTG ACAGCCAGCT AGAAAGCAGT CCTCTGACCA CAAGAAAT[G GATTCTGCCA ACCACTCAAA TGAGCAAGGA AATGGAT~cT CCCCTAGAAC CTCCAGAAAG GAACACAGCT CTGTAATGCC 'FrGATI=AG CCAGGTGAGA CCTGTIrCAG ACTI]GACC TATGGAAATA TAAGATAATA AAG=rIATI' GTATGCTGCT AAATIGCGG TAGM~ATTA CTGAAGCAAT GGAAAGCCAA WO 00/09525 PCT/US99/1 7712 EPI-109 140 TACAGACAGA ATATACAGAG AGAAAGAGAA TGAGTrCTI CCTGATAA17 TGTAAATAT-r TGGGTCT-rCA CTGGACAAGC TT~CACAGAGG ATrCACTGGT TCCCTAGCAA ACCAGCATGT CCAGTCCTGC AGCCTCCCTT TcTrAGGCCC AGCATATGTC AGCTGTGTGC ATAGAAAAAT CAAAGCAGGA CCCTGAGTAG TTGGAAAGAA AAGATGGI1G GAAATGGGTT GCACITCAAG TGAGGAAACA AGAGGTAGGA GACCGGCATC TC=rCTCAT ATGTCCCAGG CTGACTC17G TGAGT7GMT TCCCT-rGGAG GCTATCGATG ACAGTCACAG TAACCTGATG GAACCTGGAT CATGATGAAA GAAGTAAGTG TCAATGGCTC CGACrrCCAA GGACrTJGAT GTCCCACAGC ACTAGCTAAA CAAAGCCAGT TGGAAATGAG =~AAATGGG GAATITCCTG AATATATTCC CTATTGTrAG GAAGCCAGGT TGGCTFC=T GCCTACAATr ATGCCAAGCA GTCACACTAT AGAGTCCCTA GGGACATGAT ATlAAGTGAT TCTI=AACA CAAACAACT7 AATAATCAT7 TATACTAATA GCAAAACGGC CAACGGCTGA TA FrCCAC~r GAAGTAGAAT TGGCTATCCA ACTGGAAGAG AAGACAGGAA GACGTGATCT CCAGGGAGCC ACTFAAAAGGA flGGCACCTG CCTCTGGAT7 CCCCTITCC TTATA17ACC TCTCAGCACT GGCAGGCC1T TA IMCAGGA TACAGTICA CAAGTATTAT GTCACGTCTC TGAGAA17AT GT7GGTAGAT A 1TGCTCCT CTGGCCAGAA AGAC~TAGTT TGGAGTCTGG AGTCATGAAG GTGACATACA TGTAGCTAGT GACATAAGTG TAGCTAGTAA AAATAGTGAG TAATGGCCCT GAAATTCTAT TGAATGCCCA AAGTGCTGAC CAGGAACAAG CATGCTCTAG CTrATCTrCAC AAGGAA=TG ACAA=T1I TCAAAAATCC TAGTAGCTAA GATMCTTAG TAACAAAGCC ACTAAGGCAC AAT7rATGA'IT AACTrGACCC 'rTAGGTGACT MrAAGGACT ATrCTATAAA ATATTACAAC TAATAGTGGA TCCAAGCCAG CACACTCTGC TATATAAGAT TAATTGACAG TGTCCACACT GGTAAAATAA GTrGTrTCAT AAATACATTA GAATrCAMI GCACI=CTA CACAGCCCCA AGTCCAGAAC IMCCCCAGA ATAGGTCTAT G=ITGCAAT CTGCTACTCC ATACAGAGAT TrGAGTTCAC TTGGCAAM~ AGTGCTGCTT ATATGTGACC AGTFTAGTCTG T1TACTAT CTATGCCTrA AACATrACTA TACTTACTAA CTCCAAGATG CCTGGTCTCA ACTTGACAAA AATACCCCAA GTrGGGAAAT CCTrATGTGA ATATGTAGAT AGTCACAAT7r GCTGGT7GAT GATGATCTGT C=rCcTGT ATTFGAGAAA ATGGAGATAA AATGGACCAA TCCAAATAAT GGATrAAACA TGGGAATAGG TGAGAGAGAG AGAGGAATAC ATGGTGGCTC TCAGTGTCTG GCTrAGGCAG TAAACACTI CGTTAATAAA GACGGAAAAT AAAAAAGGAA TAATrGGTGT CTAGGGGAAA ATAATGAGCT CAAGTI=AA CACTCTGAGT TCCCGGATGT GAGACATCCA GGCGCATIT7A TCCAAGAGGC AGrrGGAAGC AACGT'rCCGG AG=TAGGAG AGAGGCATGA CCAAAAGCTG GTGGGACTrGT GAAAAGGTAT GGCCAT7CTG GAAAACTGTr TGGCAG717C TFAGAAAATT AAACATGTAC TAACAACCCA GCAATTGTAC TCTTGAGCAT FrGTCCCAGA TAAATGAAAA AAAAAAAAAG CAITITITT ACACAAAAAC ATATACATGA AAGT7CATAG AAGTGUrATT CATAAAAAAC TGGAAAAAAC TGAGATGTCT TrA'ITGAGTG AATGCTrAGG CAAACGGTGG TCTATCCATA CAATGGAAT7 ATGCTAGCA ATAAAGAGAA AAGAACTATr GATACATGCA ATAACACAGA TGAATCTCAA AGGAATTAAT GCTGAGTGGG AAAAAAAGCA CATCTCAAAA TGGTATATAC TGTACTA717 TATI1ACT7A ACA T=AAA AATAGCAAAA TCATAGAGAT GGAGAACAGA TTAATGGGTA CTGTGT=~G GGATGGGGAG TGAGAAAAGG GTAAGGTGTA AATATAAAGG GGTAGCACAA AAGAGCCTrG TGGT7GAAGG ATrCTATGTC TTGG'ITGTAG TCGTGATTGC AGGAATCTAC ATGTGATAAA AflGTATGGG TCTACATACG CATACACACA AGAGCATATA AAACTGGTGA CATGTGAAGA AGCTrCCGCAC AUTGTGCCAA CATCAGTATC CTAGTICAA TATCAGACTA CAGT7ATACA AAACAT7GTC ATTGAGGGAA ACTGGGTAAA GGGAACACAG GACAITrGGC ATATA7TTT GCAAMhCCT GTGAATCCGT AATTA T1AA AAATAACAGA TATACTACAT ATCAAAAAT7 TAATGTCATA AAGTrGATGA G'IMACCTAG TGGATAGCT TGTFAATATC TGCTrATAAGA CTACTGAAAA TGACAGTrAT GCAAGTATAA GCTCAGAGAA C1TCCTCCC C=~CGTAAA TGAAATGAGC AAAAGAAATG AAACAGGAAA GGCAAGCAGT ACTGAAAACA GGGAAGGGCT =~CCCCATA TAACTATATC TGCGACTTCA ACAGCTATTC ATCCAGAAAC ACAGCCTCTr GCGCTAAGAG GAAACTIGG ATAACAATAT GTITCACTC TCCAAGAGAG AAAATGGATA GAT-rAA=IF TAAGAAAAAA AAAAAAACCT CACCAATTTC ATGCTGTGGC TrGCACC'I I AATCCCAGCT ACCTACAAGG CrGAGGTGAG AGGCrrACTT GAGCCCAGGA GTTCAAGGCT GCAATGAGCT ATGATrGATr GTGCTATCGC ACTCCAACCT GGAGTACTAA GCTAAGAGCT AAGAACACAG CTGAGAGCGG AGAAGAAACA AACAAATCI'G ACCAATAACC CCCACTCCCC TCATI=ACT GGAGTGAGCT GAGACrGCTG GCAAACATGG CCT=GACCT AGCCTGAACT GTAGCAAAAG TCATCAGATA TrCCACC AATCAACAGA CAGAAGTGGG GAGAAAACAA TCGTAGT7CA TAACTACAAC AAGCAGATAA ACGAAGGCCA TGGTGAGGGA TGGAAGACAT TGTGATATAT CAAAGGCAGG CTCATITAAA A~rCAACCCA AA F7CCAAAC AAAATATATA ATrGAATATG TAT-rAATGCC AAAGGAGCT GAGTGAGCTT TAGCACAAAC CCCGCCCTCC AGCCCCCACC CAAAAAAATC ACTCTGT7CT CTCCCCATrC M~GATAGGC ATAMTGCTG TI=CTCACA GCCAAGGTAC AGAGGGGACT TAGAGGAACT AGAACTCTAA TACACTGCTA GCAGGAATGT AAAATGAAGC ATCTACTTCA GAAAACCAT7 TTATCAG=~ CTAGAAAGT7 AAACATAGAC CCACCATGCA GCCCAGCCAC TCTACrCCTA AGTAMTACA CAAGAGAAAT GAAAACGTGT CCCCACACAG FrGTATITAA AGGTGATGGT TAGCCITGTG TGTCAACTTG GCTAGGCTAT AATACCCAGT TACTGAATCA AATAGTAATC TAGGTGCATC TGTGAAGGTA 'ITGTAGAT GTGGTITAACA GCTACAATCT GTrGACT7CA AGTAAAGGAG ATrGCTCTTG ATAGTATGGG TGGGCT~rCAT CCAATCAATf GAAGGCCTTA AGAGCAAAAA GTAAGGTF7C CCGGAGAGAA AGAAATrCTG CCTCAAGACT GCAGCCTCAA CTCCTGCCTG AGMTCCAGT CAGCCAGCCA GCCTAAAGAT TTGC"TAGGCA TTATAATCAC ATCAGCTAAT TTCITAAAAT AAACCTUI I ATATATAT17G ATACAATGAA TGGTTATAGC AGCCrTA17 GTAATAGCCA CAAACTGGAA ACAACCTAAA TGTCC7IrCAA TAAGTGAATA CATAAACAAA TTGTGGTATA TCCACAATI TTACGCAGCA GTAAAAAGGA ATAAATGGTr GAATAAGGAA TAAACACATA ACAAGGATGA ACCI1TAAAAC CGTAAGGCTG AATGGAAAAA GTCAGACAAA ACTAATACAT ACTGAATAAT TCCATITATA TTGAAGTTCT AGAAAATGAG GACTAACCTA TAGTAACAAA AAGCAGAAAA ATITGCCCA CTGGTGATGG AGGGGGCGCA GGTA~FrGTAG AGTATCTGAG AAAGGACAAC TGGATAAAAG GGGGCACAAG AAAACTTTG AGGGTGArTG ATATGTrCAT TATCTGTGG CATGG=IICA TAGGTGCATA CATATGTCAA AACATCAAGT TATACAC'I I TAAAATGTFC AG=~ACTGT ATATCTATTA TACTrCAGTA GAGAGGAAGG AAGAAAGTGG GCAGGGTGGG GGAGAGGAAA GGAAACGAGG GAGGAAAGGC CCTAATAGGA AGGAITIGG AG'IMAGATT TFrAAAATGAT AAAGGATG F7 TGACACTCTA GGCATATGAC GAATATAGGA TTATGAGTCC ACAAAAACCA CCAGGAAGTC ATGTATGTF7 ATAC'IIAA GTGAAGGATC AGTGGA'ITAT CAACTCCCTA ATGCI=GCC TCTCTATGAC TGGCTGCTGT CCFCATC CCAATACTCC TrCCAAAGCC CCTGCTrAA ATGTAAGCCT TCTTCCTCC IMCAACACA TCCTGCATTC CGTGACAAAA TAAG1T=CC T7AAACAGAA TGTACAGCAT AT7ATTTGTA CAATrAAAAA 'TrIGGCCA GGTGTGATGA CTCATGCCTG TAATCCCAGC AA717GGGAG GCCGAGATGT GTGGATrACC TGAGGTCAGG AGT7CGAGAC CAGCCTGGCC AACATGGTGA AACCCTGTCT CTACTAAAAA TACAAAAATT AGCTGAGTGT AGTGTGGCAG GTACCTGTAA TCCCAGCTAC TCAGGAAGCT GAGGCAGGAG AATCG=flGA ACCTGGGAGG TGGAGGTTGC TGTGAGCAGA GATCAGACTA 'FrGCATTCTA GGCTAGGAGA CAGAGTGAGA CTCGGTCCCC AAAAAAAAAC ACA7TIT= YrAATG'fC CTCCTTGCCr GTAGGAAAAA GGCTCTGACT CCI'TAGCCTG GGCATCAGAG CTCTATCTAA ATGGA(:lI IA ACCTGATI= GTGGCACTAA 'ITCCATrGCA GTACTrGTCC GCTCACTGGC CTGTGCCTCT CTGCCACTAT TITGGAATA ATGTCCTCTC TCCATCTTGT TTACTCAACT ATATCCAACC TCTAAGGCTG TGCTCCTACA AAGCCTCCCC TGGCTACTTC WO 00/09525 PCT/US99/1 7712 EPI-109 141 AGCCCACAcIA GATA'TrFAAC TGCTCTGCAG 'FrCAGGACAT TCTrCrGACT CTTAAATCA CATr7ACTrA TATATGATCT TGTGATA 1T TTGTrGACG TG'ITrAUI= AA'n=CrrC CATAACCTAT TCATTCAACA AACTCAACAA TFATATFA AATGCCAAGT TAGAAAAATA TrATrGA'1 TATATAGATT ATAGATATGT TFGAAATI= A ITGGCAAT CTGCAAGTAG AAAAATAAT7 ATAATGTGGT ATATCTGTGA TAGAAGTAI1 AGTGCAGAGA CCATGGGGAA CATAATCCAG CCTGGAAGTr CAGGAGAGAT ACGTGGAAGA AAGGACGTCA GAGCCITIT CCTACAGGCA TGGAAGAAAC ATTAAAAAAA AlIIITT T'rGAGATGGA GTCTCACTrT GTCTCCCAGC CTAGACTGTG GTGGTGCGAT CTCTGCTCAC TGCAACCTCT GTCTCCCGGG TrCAAGTGAT TCTCCTGCCT CAGCT7CCCA AGTAGCTGGG ATTACAGGTA CCTGCCACAC ATGGATGATA AATATGATCA TATITCT-G rCn=CC CCTCAGTTGT CTrCCCTGAA GAAAGGAATG CC'IrATAG ATGACAAACT CCCA7TrCCA AGAACAAGGA 7IrIGACCA ATrAAnh7A ATCAGATGTC TGGCTTGAC CTAGAAACAC AGTCACGAAA cITGGTGATr AGAGACCAAT TCCCAAACAT GAGCAMTCT TAGGAAACAC AGTAAAGATC TGAGAGACCC AAGAGCAGAA GGGCGAGAAA CCAAAAGCCA TCAGTTrGCA TAGGAAACAC CTG 1TAGC CTAATC'Ir TArIT1A'n? ACTC7TTfAG TCACTACAAC TATITCTGA TrGCTATGGT GATAGATGGT TrAAAACAAG CC~rCATrAA GAATrGTCAC ACCATGGTCT CAGTCAAAAA CACCAACATrT 1TrATTGGTA TrGACAAT7A TGGGAATATC CAAI7CCAAG AAGACAAGGA GACCTCTrGAA CTICTAAAT GAAGACTCCA ATC=CCTGA TCTGATGGGA AGCAG=FGG CAAGATTACC AACCACCACC ACAGAGAGTG GACTCTAAGC TAAGACTTAA AAGATAAGTA GAAATTATCC AGGTAAAGAT GTGTACAGAG AAGGAAGTAC ATCCAGGGGA AAAGAACAAT ACGTGCAAAA GTACGGAAAT GGTAAAAAGT AATACTACAT AGTCAAAGCC AAGCAGAGTr CAGAAGGGAT CTGGTGGTGA AAAATACGGC TAGAGAAAGC AGCAAGGATT GGCTI'CTAAA ACCTATGTAG TATCTGGAC cTrACCCTAA ATGTAATGAG AAG=~CTAA AGAATCI=C ATI7AT-rCAT TCATrGAACA AATATITGA GGCITCTGT GAAGAACATC ATrCTAAGTA GTAAAGATAC AGCAGTGAAT AGGACACATA AAATCC[AGA TCTCACAGAA F7GACAT7CC AGAGAGGGAA AGGTAGACAA TAAATACATA AACAAATCAT TTAACAAGAT GAT7FCAGAC AATGGTACGT ACTGTGAAAA AAATGAAACA AGGTAATGGA CAGCGAAAAG GCACTGGAAG GAAGCCTGCT TACCT=GCA TGGTrAGAAA AGATCTCTCT AAGAAAGAGA CCACATGTGA GCTGCGACCT GAAGGATACC GAGAAGCTAG GTGTGCAAAG ATGTGGGGAC AGAACTI=G GACTGAATAG CAAATACAAA TGCCCTTGGG TGCAAGC1T GCCTGTrCAA GGACCAAAAA GAAGGCCAGT GTGCCTGCAG CATACTAAGC ACAGAGGAAA ACACTG7rAT ATGCTGAGAT TGGAATrATA AGTAGAGCCA GATAATATAG TCTCTATAG GTCATAATAA GGCAACCAGA =IT'TCCA AGAGGATIA AAAATCACTG GAGG=FTGC ACTAGGGTGA GAGGTGTGAT TI'GTAT7TI AAAAGATAAT TCTGGAGAAT TAACTATAAT GAGGTAGGAG TAAACTAAGT TAGGGGCTAT 17CAGTGGCT CAGACAAGAG ATAATGGTAG CTJ7AGACTAG GATAGTAGTC GTAGAAATAA ATAAAAGTGG CACTCrA=T TGGGGGTAGA GTCTATAATA GGTI1GGMT ATGGATCATA TATGAGAGTA AAAAAAAGAA AATAAA'ITAA TAATGGTTCC TAGGTTrGTA CCTGAGCAAC TGAATAAATG GGTGCTGTGA AT7GAGATAA AGGAGATrGA GAATCACAGG C'=GT=rG CAAATTAATT TTGAGAGGCT TAT7AGACAT CCCAGTGGAG ATTCAGGTG AGTGGAGCCC ATTGAAAGGT AAGGGACAGG GTCAGGTGTG GTAGGTCAGG CCTGTGATCC CAGGACI IIG GAAGGCCAAG GCAGACAGAT CAG'TGAGCT CAGGAGTTG AGACCAGCCT GGGCAACATG GGAAAACCCT GTCTCTACAA AATATGCAAA ATATTACCrG GGCATGGTGG CATATGACTG TGGTCCAAGC CACT~rGGGGG Gc7GAGATGG GAGGATCACT TGAGTACAGG AGGCGGAGGT TGCAGTGAGC CAAGATCTCG CCACTGCAAA CCAGCTTAGG TGACAGAGTG AGAACCTGTC TCAATAAATA AATAAGAAAC GTAAGGGAAA AGGAAATTAA TCrGATCATr GGCAAATGCA TAGTAITrTAA AGCCAGGGGA GTAGATGAGA TACTCAAAGT AGGTGAAGAT AAGGAGGCAA TGAAGGCCTA GGACTCTGGT GTACAT17AG ATGGTrATAA GAGGAATAGA AACTGGCAAA ATAAGTAACA CTGAGCACCC AATGAGGTGG AGAGGAAAGC CAGGAGATGA AGCATCATAG AAGGCAAGAG AAGAAGGGTG TCAAAGAGGC GAGGCAGTCA TCAACTCTG GGCAGTCAAA TAATATAAGG ACAGAAAAGT GACCATrGGA MTGGAAATA TGATGAGCAC TIGAGTGGA GTGTTGAGAC AGAAGACCAA TI7AGAGTAGA TTGAGGAGAT AACGAGAAAT GAGAAAATGT AACCTGCAAG CACAGACAAT TCTGAGAGA CTICTGTG AAAGGAAACA GACACAGAGT =~AGCATGT CT7GTCTTC TATGGGAAAT GTAAATAG Fr TGAGATCAGG GATAGTATI7 TAT7CTGCT7 TFITGTACCTC TACATrACCT AGCATAGAGC TAGCTAATGT GCACT17AAGT ATGTrCTCAA 'TCITATCGC CTGAATGACT GGATGGGTGA AAGAATGGAT GGATGGATGG ATGGATGGAT GGAAGGATGG ATGGATGGAT GGAAGACTI'C TGATITGCCA AGAAGAGGAT ACTGGTAGCA GAAATAAAAA CAGCACTGGA GAAAGAAGAG IT1TAGATIT TATTCTGG TGTCAGTTAG ACAGGAAAGT AAGACATTAG AAGAGTCCTr AGATAAT1TA TGTAAMTGTT CACTTAGGAT 'FTAAATGT GATCACTGAT A'TrGGACATG TTCCTAGTGA AGCATFITG GTG ITCACT GG'FrGAAG'Fr AATAACTGTA AAATTA=IC CCGTTCAGGA CAGAAAAACA GAAAACTTGA AGCTCCTATT AGAAAG TTCA AGA'FrCTCTG GGGTrCTTAG GATITACTGT TCCCAAAACT CTGTCAAGAA CAAGAAAATG ACCTGTATAC TrAACrGGTC TAGGCAACAG TGGAAAGACA A'ITCrCAGAG AAGAMIGT7 TrAAGAAGAC A='~CCATA GGAATCAAAC AATAGC'TIC AGTGACTAAC ATGGTAAGAC ACAGGGTGTT AGCT-7ICC 'ITCCAACCTC ATGGCTG'ITG TACC'IACCT T7CGACCCCG TG TCCTGAA A'ITG77AAAT TCATAAACTT ACCAAGGACT AACCAGCCTC TGGGGAATrG CTGTATACTT AGCAAACTTA CAATGGACAT AMATAAGC CATAATGATA ACTGACTAAT AGGAAATACC CTCAACTGAA AATGAGAGAT CATCAT=GC AAATGAGTTC CCTTGCCCAG GCAACTACTG GGGAAAATGT CATGCAAGCA AAATrAATC7T FGAAATCCT CCTITCCAT 7IITGTGTC TTCCTI=CC ATAGGCACCA GAAATATCAT GGTGCCTGGA TCTCATCTCT ACAGAAAAAA AAAGTGATI1 GATAAACTFGA T7ATATTGT GTCCAAATGT GA17GTAI7r TCAAAGATAA CCTAAGGGGA GAATGCTGTC TGGCCCAACA GCAGGCTCTC GACTrCAITTr CAGACACTGT GGCCAATGGC TGGGAAACAG GTATGAACAG TAGGTTCTG AGTCCCCTGG AATTArCCA 717rATGTAGC CACCTCCATG ACAGGAAGCC TCCCTACrCT TACTTCCCAG ITrrGTrCATT CATGGCACCA GGTTGCAGAT TAAAAMrGC TCAGTGACCT TTATCTAAT AATGTGT'rAC =CrrCrCcr TAAAAAGTAC AAGGGACAAA TGCTCATGGT ATACT1T7AG GAGAflTGTGG CTcTCTATTA ACAGTATT7A TTCAACAAAC AITATTGAG CATIATATG TGCATCATGC TAGGGACTGG AACCTAGTAA GTGTAGCACA TATTA'IMCA T'ITAATCCTC ACAACAAACC CATGAGGTTG G1TTATGAT CCCAA TIT CAGAAGAAGA AACTGATATT CAGAACCAGT TAACTAACTG GTTCAAGGTC ATGCAATITC TAAGATACAG AACCAAGAGT CAAAGACATG A=IAAACC AAAGCITI CTGcTACTCC ACATrGcrrc CCTAGGTGAG ATCTGAGGCA 17CCGCGAAA AGAGAAGGGT CATAAAGCCA AGGGAAGACA AGC'ITAGGAA AAAAAAGGGA AATGTCCTAA ATAAACAGCT TrCCrT'1A CCAGAAACCA CTAG17AAA AATATAATGG GAAAAATCCT ATrCAC=rA ACAATGTrAA AA AAAAAAA GATAGAAGAA ACATAGGGAT AAACTrAACA CA17TGTAGG ATATGTAAAG AAACTAAAAG ATGTTAATAA TGGCCTAAAG AAAAAAAAAC TI'ACATGTAT GGGGAGATAG ACCATMTAC TGGA77CTAA TATI7AATAG TCTAGGTGTT CCAMICTCA CCAAAT7AAT GTATACA IM AATACAATGT CAAACGAAAT ATCI1AGGAA TrG=TACAA A17GTCAGAT AATrACAAAG TI7ACCTGGG AAATATAAGC ATATATGAAG AGTGAATGGG ACCCCACCAC TCCCCCCAAA ACAAAAAAGG TCTGAAAAGG ACAGAAATCA AGGAGAGTCT TGCCTGCCAG ATACAAAAT CTATrATAAA GGTGTATrGA TGAAAACAAT TrAATACTAG TGTAGCAATA GGCAGCAAAG CAATGAAACA GCATAAAAAG ACCAGAACTA TACCTAATTA TGATGAAGAT TrAAGGTATG ATAAACATGA CATAA'FrCAA ATCAGCAGAA WO 00/09525 PCTJUS99/17712 EPI-109 142 ATrGGCATAG ATAGGG FrAA GACAAATAGC TAATCATrAG AGGGGAGGAA GGAAAGGAGG GAGGATAAAA TTAGGTTCCT GCCTTCATCT TACATI'AAAA TAAATrCCAG ATGTATTACA M~AAA I= IMAAAAAAA GAAACCACAA AATACTrGAA GAAAATATAA GTrGTrATAT AGTCTIIGA TGGGAA=Ir 'flTTflC AGAGACAGGG TCT7GCTCTG TCACCTAGCC TAGAGTGCAA TGGCATGATC ATGGCTCACT GCAGCCFI7GA ACTCC!TGGGC TCAAGTGATC CTrCCCAGCTC AGCCCCCCAG GTAGCAGGAA CTACAGGCAT GCGACACCCC ATCCAACTTA 'TITA'Im TrGTAGAGA CAGGGGTCTr GC=~GTT7C CCAGGCTFAT CTCGAACTrC TGCCTTCAAG CACCTCAGCC TCCCAAAGAG CTGGGCTGAT GGGACA=II 17AACATAGT GCCACATFAC CATAAATGAA AAGCTGTAA AATACTAAT7 717AAAACTA ATATATATCA GAAATI1TA TAAACAAAGT TAAAAAGCAA ACACAAAAAA 7rrGTAGCAC TwrATGACAAA TATATGTATA TATATGAATA CAAAAAGAGC CITIACAAAA CAGTAAGAAA ACAATGAATA CTCCCAATGG AGTAT-rCAAA ACTAAACTGC TAAAAGCAAT TCAAAACAAA AAACATAAAC TATGCATATA TGTATGTGAA AAAG IMAAC CTrATCAAAG AAGTAAACTC TCAAAGAAAT AAACATCAAA TAAGGAAATA GCCF1TCCC ACAAATAACC AAAATCTGTA AGAATACTGA GCTGCGAATG =~CAGAAAA AAAAAAAAAT CATACACC]TA GTrCGGCATG TAAITrAATAT AGATCAGAAC A='~AAAAA TA'TTrATAGG CCAGGCACGG TGGCTCATGC CTATAATCCC! AGCAC=IGG c3AGGCCAAGG CGGGTGGATC ACCTGAAGTC AGGAGTTGA GACCATCCTG ACCAACATGG TGAAACCCTG TCTCTACTAA AAATACAAAA ACTrAGCCAGG CATGTrGGCG TATGCTGGTA ATCCTrGGCTA CTCGGGAGGC TGAGGCAGGA GAATrGCTTG AACCCAGGAG GTGGAGGTTG CAGTGAGCTG ACAT7GTGCC ACTrGTACTCC AGCCTrGGGCA ACAAGAGCAA AACTCTGTCI CAAAAAATAA TAATAAATAA AAATAAAATA IMATATACT CTGACCCATC AA'TrGTCCA GCATAAUTAG GCATGTGTAC AAGGG'IMAC ACACAAGAAT GCCTATrGCA ATATTG='~ TAATGCTAAA AAAAATrGGG GAAAATGC TT TAAAAATATA GA'ITAAGACT GTACAT7GTG GTACAGTCAT ATAATCAATA GTATACAGCT ATA17T TwrCAGCCACT GTCCAAAATA TAGCCTGGCC TAACAACIT CTrGT7AGGAT ACGCAAGCAC CGTGAGGAGA TCAGCTATAA AGTATCAGTG I17CACACCA CTGCTCC=I GCTAATAACC TTCAATGGCT 17AAAGAAG TAAAAAACAA AGGCAAAAT7 CCTAGTCAG CCCTTAAGAC TC~rCTGTTAC TITAGCrCAAA CTACCCF1T CAACAACACT GCCCTAACCA GGATGAG'I7r 7I1GCCCCCC TGGAGTACAT TCAGCC'TC CTATCAAAC =CrCcrrr ATAAGTATCT TCTrCCAGGAC CACflCA=fl TC1CCCCAA 'IMAGCA17 TCTATATCTC CAGGCCTACC TCTATAAAGC CTGTCCTAAC CACTrCAAACC CTAGCTT717 CTrCTGAACTG CTAGAAATAT T=~CTCTCA 'FrGGCCAn7~ AGGTAAAAAG GITI=rACTG 'ITTATTACCT ACTCAATAAA AA=C1T TTFGAGACA AGGTCT7ACT CTGTCGCCTA GAATGGGGGG AAGTGGTGTG ATCACAACTC ACTGCAGCIT CTACCTCCCA GCTCAACAGT CCTCCCACCT CAGCCTAGTG AGTAGCTGTG ACTACAGGCA TGTGCCACCA TACCCCACTA CI=rCAT17 TITATTI1 GTGAGATGGA ATCTCACTAT GTTACCCAGG CTGGTC~rGCT GATCTCAAfl GATCCTCCCA CTGTGGCCTC CCAAAATGCT GGGATrACAG GCATGAGCCA CAATATCrGG CCCCAGTAAG CTITAAGGC CATTAACATG AGGAACAGTG Tr=1TACAC TATITATCA GCTAGGGC1T TGCATGGAGT AGGAGTrAG TAAATGCGGT TGATGGGTTA ATCAATGTGT GAAAATATTC AGAGCCACCA AAAACAGATA TTATGTCTAT TCTCATCAAC AATCAAAATT GAGTAAACAG CCATITCTA ATACAGGAAA CCACAAAACA T-rGAATGGTG ACAITAAAAA ATTCCCCCAG CAGGAGCCAA CCAATT1T CATCCTGATC CAAGTrAGCA AACTGCAAAA GATAGGAAGC ACTAATGAGT GGAAA'IMGA GTAGAAGCAT TTCTTATGAA GGCTGTCTTG ACTGGATCAC A'TITATrG CTGTTGGAGG TGCCAAATGT GTGTGTIAT GCTAATCCTC CACCTCAGGC AACACACAGT CAAGGATCCT ACCAAGTGIT ACCGTCAAGT GTCTG ITGGC AGCTCAAGGC CCCAGCGTrG 11rCCCT1'GCA CTAGGGAAAA GACATATTCC AGGTACAAGT ACTCCCACTT TGATGCTrACA GAGGAGTTGC TGAACITGT GTCATrAATC TCTCTrCGTT AGATCCCAAC CCTGTIAAA TCCCACTATC TGCCTACTCT GGGTCUTCAC CAAMACTA GATCATAGTF GGAGAAAATC TACAAAGCCT TGCTCCC=~ AGA'TrTAAAC AGGTCTCCGT TrAAATTTAG AATrGCTAAC TTCAAGCGGG CCCFATGCG ACAGTATGCC TGTCAGTCAT ACTACA T1C CTCAATTCCA TTCATGTGAC TGCTCCATAC CCT-rCCcTCT cT=TCATAC TACTATTATC TM~CCCCCC TCCC7CAM TrAACTGATG ATCTrG=~C CTAT-ffCTCTr GAGAAAATAG AAGCCATCAA AAGAGAGfTT CCACAAACTC CTACTGC=I ATCrAGCCCT GTACCATATA C'TrGCATPT' CCTCTCATTA CCATGGATGT ACTGCCTATC TGTGCTrCTA TCTAAGGCTA ACCC17CCAC TTCAG=ITG AATATFATCA GCTCITACCA ACTCAAGGCC ATTGCTrCTAG CAATTCTCTrC A77rrCCTCTC A'TrrCTrCC ATCAAG11 CCC'TTC AATTAACAGA GTAGCTCCTA AAGGGAAAAA AAAGT=~CT =IPCAATGC TCATCATCAC TGGCCATCAG AGAAATGCAA ATCAAAACCA CAATGAGATA TCATCTCACA CCAGT7AGAA TGGCAATCAT TAAAAAGTCA GGAAACAACA GGTGCTGGAG AGGATGTGGA GAAATAGGAA CACI=ACA CTGTTGGTGG GACTGTAAAC TAGTrCAACC A'FrGTGGAAG ACAGTGTGGC GAT-rCCTrCAG GGATCTAGAA TrAGAAATAC CATTGACCC AGCCATCCCA YJ7ACTGGGTA TATACCCAAA GGAT7ATAAA CAATGCTGCT ATAAAGACAC ATGCACACGT ATGITTTA7rG TGGCACTACT CACAATAGCA AAGACTI'GGA ACCAACCCAA ACGTCCAACA ATGATAGACT GGAT[AAGAA AATGTGGCAC ATATACACCA TGGAATACTA TGCAGCCATA AAAAATGATG AGTTCATGTC CMTGTAGGG ACATGGAGGA AGCTGGAAAC CATCACTCTC AGCAAACTAT CACAAGGACA AAAAACCAAA CACTGCATGT TCTCACTCAT AGGTGGGAAT TGAACAATGA GAACAC'FrGG ACACAGGAAG GGGAACATCA CCCACTGGGG CCTGTIrGTGG GATGAGGGGA GTGGGGAGGG ATAGCATrAG GAGATATACC TAATGT7AAA TGATGAGT7A ATGGGTGCAG CACACCAACA TAGCACATGT ATACATATGT AACAAACCTG CACG FrGTGC ACATGTACCC TAAAACTTAA AGTATAATAA AAAAATATAT ATATATATAT AAAACAACTrA AAAATAAATC 'ITCTFITCT GCAGGATCAG TCCATCACCA CACACACAGG CTGTG=FTA TG T G1TCCC CAGCT7AAGA GATCGTrCrC CAGATCCCAC TGCTCCTTCC AG I1GTCACC TCAGTrCTCC ACTrCTFIT GCTGATAAAC TACTCTAACT AGTTACATAT GATI-rCTGTC CCCAGGTCCC CTCCCTCAGT TG=IIGAAC ATAATCAM] ATATCA ITA TCATITCAC TCTAATrGCA CAACCAAAAA CTCCCITI= TIAGATGG AGTCTrCACTC TGTCACCTAG GCTGGAGTGC AGTGGCATGA TCTCGGCTrCA CTCCAACCTC CGCCTCACGG GTTCAAGTGA TCCCCCX3CC T-FAGCCTCCT GAATAGCTGG GATrATACAC ATGCACCACC ACACCTGGCT AATTGCMTG YT=TGM~G TGTGTGTGTG TGrflT1I TITr=GGA CAGAGTCTCA C7CTGT7GCC CAGGCTAGAC TGCAGTGGCA TGATCTCAGC TCACTGCAAC CTCCACCTCC TGGGTrCAAG CGATrCTCCT GCCTCAGCCT CCCGAGTAGC TGGGACTACA GGCATGCACC ACCATGCCAG GCTAA ITITT IGTA=T1C AGTAGAGA CC AGG=rCACC ATGTTGGTCA GGCTGGTCIT GAACTCCTGA CCTCAAATGA TCTGCGCACC TGGACCTCCC AAAGTGCTGG GATrACAGAC T7GAGCTACT GCGCCGGGCT ATITGTGT7 TW1TAGTAAAG ACGGGG'IMC ACCATGTTGT CCAGGCTrGGT C TCAAACTrCC TGACCTCAAG TGATCCGCTC GCCTrCAGGCC CTCAAAGTGC TGGGATrACA GGAGTGAGCC ACCATGCCTG GCCATAAAAC TGCCC'I=GT TAATATGACT GT7GGCCTGC ACAT7GTCAA ATCCAGTGGC ATTCATCITA CTCGGCCAAC CTACGGCATT TGACACTGTC TGTCTICCT TCTGT7CCTC TATCTrG7ITC CAGTATACTG GCCTGGCTI1 C'TI=ACCT CITIATATG CT=TCCAGT CTCAGGCTrCC TGGGGAT7 TGAAGGTATG TrGCA'r=G CTATTCAATG AATAATGACA AGTAATGATC ACTAAGACA TTAAGTGGTC AGTTCC1TA CTAGGATAAA AATA.A=I~C TTCCCAACAT GGGGCATATT CCA'ITCCAG TC TGACTGTr CTGTGTAATC TT17GTATTCC TTGGCAGCCC CTTIATATC AGTTCATCTA CTGTGCAGGA AATTGGACAA ACATIGCAC TGGTATAACC AAATACAGT7 GAACT=TGG C F7GACT=T AGCTGAACTC WO 00/09525 PCTIUS99/1 7712 MP-109 143 ACCAAAAATA A'IrTGTAA GAGACTGAGA CGTCTACGAG TAGGTIT=C AGAATrAGTA AACATAAATC AAGGATACAC AGGTAGATIT GAA'I=CAGA TAAACAACAA ATACTIT= AGTATGTCTA CTGAAATATT TGTATCT7AT CTGGCAATI7C TACCTGGTAC AGAACTAATC CAT7CCTrG AAAGATCTTG ACTCTGTAAT AAGTrCT7TrG GTGATGGAAG GGAGGTATr7 CTGTAATrAG AGTCACTGTC TTCCTCCCAG TrTFI=ATCC TGGCCCAGAT CTGCAATGAA CACACGACAG AATCCAGGGG GGATGAAGAT GGGTG='~G CAGGAAAAAA AAATTAAAAA CATCTGAAAA AGCTITGTA CTAAAAGAAT GTGATCTAAA AAAGAAAGCA GGAGAACTr CTGTCTGCAC TflACATCAG AACAACCT7G GCGTCTAGAA GCTGTGCCCT GTGGGAAGTG GTGGTGCT'rG GTAAGAGATG CCAGGACCAG TGGTACCCAC TGGGAGCACT GCCAATACCC AGCAAGGAGC ATGGGTGCAC AGTAAGGCAT TGCACTGTGA TTCAGCATAA AATAACAATA AGGGAACGTC ACGGAGAAAA GGCCAGACTr CC'=GTrTA GAATGTGGGA AATGTC=CT GAAAAATGGT AGTAAAAAAG CATGCTrGGA TGGTCCACTC CAGGCAAAAC TGACTAATCG GGGGTCAGGG ATACAACCCC TGCATCATAT GTTTGTITCT GTGGGCTGA CATGAGG'ITC ACTGTGACCA CTGTGGnI7A ACCCCATAGT CTCCTGGAAA TACAGCCAGG TCAAGAGAGC TCCACATAAA ACATAATCAA AAAAATAAAC TCAAG=~CC ACTGATCAGC TI=CACAAC TCTATCCT TCACTAACTT TGGAGCAAGA M~GAGAA~r GGATGGCTAT rrGAGGGCTA TTrrCrGCGCT TrAGTrCAAT G=I~GT7CT TrCTTrATTA GAGAACTATG GT1TITATr ATATFITACAC TnTAAGTrCr AGGGTACATG TGCACAACGT GCAGATTGT TACACAGGTA TAAATGTGCC ATGTTGG=~ GCTGCACCCA TCAACTCGTC ATTACATrA GGTA ITCTC CTAATGCTAT CCCTCCCCCA GTCCCCCACC CCCCGACAG3G CCCTGGTGTG TGATGrCCC CflCCTGTGT CCAAGTGTrC TGTI7rATGTG ATAGATrACG M~ATTGAT7 TGTGTATGIT GAACCAGCCT TGCATCACAG TCACITGCT7 ACAAGAAACA AACACTrCAC AGATGGATCA TTATGTGTGA TAAGTGAAAT CCAAGGATT ATGCTCAGAG GTGGGCTTAA CAGGTAGGAA GAGCAGTATr TrCCFrCAAC CATGAGTGTA TGCAGG=II TCTIrCT 'ITGAGATGG AGTCTCACTC FTACCCAG GCTGGCGCGC AGTGGTGCGA TCT7GGCTCA CTGTAACCTC TGCCACCTGG GT7CAAGCAA T'TCTCCTGCC TCAGCCTCCC AAGTGGCTGG G1AT7ACAGGC ACCTGCCACT GTCTCCGGCT AA7=1GTC 'mTAGTAG AGATGGGG'T TCACCATCT7 GGCCAGCCT GTCTI'GAACT CCTGACCTCA TGAATCATCC 7FrCTCAGCCT CCCAAAGTGC TGGGAflACA GGCATGAGCC ACTGCGCCCA GCCCACAGGT TITCAAAGA CTAAACTTAA AAAAAAAAAA AAAATTCCC AATGAAATAT AAAACTAAAG TGCTAAACTG TGATAGACTG ITIACAAGA ATGCCAG T1 TCACAAGTGT CTATAGAACA TGTAAMAG ATAGGTAAGA TGAAATITG ATAATAMTG ATGGCAAATT TAAACAGGTA TACAACAAAA ATAAAAT~rCT AAGCCCCTCA ACCAACTGAA TGGACTCCTT CTCTCAGCCA AAGGAATACC AAAGTAAACC TGAAAAACTA GTITGGCCA GGA ITGGGGG TAGGTGGGGG AAGCCCAACA TGACTCATTA ITrCTCTCCTC C='~GGAAT TCAGGCACAA CTGAATGTCA GCAT7GACAC TAAAACACAG AT=TAAGAC TGACAAGCCA GACTCT=GT AGCAGAGAGC CAGGCCCTGG AAGAAATCAA GT7A1TFAT CCCAAAAAAT A'ITITGA TATATI=CA AATGGCCCTG CAAAGCTGTC TCITGTGGGG AAAATTGACA TGCTGTACAG AATTTC=TC TCTTCCAAG 7II=ACrGA TCCAGGAGAG A'TT7AACTAA GAGGCrAGCA TGTITTT= 'I~TF~rTGAGGCGGAG TCITGCrC-TG TrGCCCAGGC TGGAGTGCAG TGGCGTGATC TCAGC]TCACT GCAACCTTCG CCTCCCGGGT TCAAGCGATr CTCCTGCCTC AGC=CCCGA GTAGCTGGGA TTACAGATCC ATGCCACTAT GCCCAGCTAA TI=rGTATr =ITGTAGAG ACAGGGTI1C ACCATGTTGG CCAGGCTAGT ATTGAACTCC TGACCTCGTG ATCCGCCCAC CTCGGCCTCC CAAAGTGCTG GCATTACAGG CGTGAGCCAC CGTGCCCAGC ACAAGACATT TACCGTCTAT TCTCTCTGAA GCTACTATCT AGAGGCTTCA TCAACATAAT AAGACCCTrG GTCTCCACAA CTCMTATC1T TATCCTAT7A G'ITrACTG ATTCCAGGTC MTAGATAAT AACAACTCI TCAACCAATr GCCAATCAGA AAGTCI=GA ATCCACCTAT GACTTAAAAG CCCCACTCCT TCAAGT7ATC CCGCCT=CT GGACTGAACC AATGTACACC TrATATGTGT TGATGGATAT CTGCCTGTAA CITCCA'ITCC CCTAAAATGT ATAACATCAA GCTGTAACCC AACCAC=IG GGCACATGTT 'FrCAGGAACT CATGAGACTG TGITrGCAGAC CTrGGTCACT CATA1TGGC TCACAGTAAA CTrC=~AAA TAT17GTATAG AGTITTGGCTr =I~CATrGA CACAGGAAAA ATAAAGAATT GGAAGGTCTI7 TCATCAGTCA CrGAGCCAGC FrCATATCrG ACTGAGGTCA TACAGTrCAG TGA'IMGTAG CTIGCTACT TAGATTGCTA TCCATrATCT AGAAGCATCA GGATCACGTG GGACCTATTG GAAATGCAGA CT=CCTCCT AGAACCCAGG AC=TGGAAT ATrCTrGGCA CATAGTAGGT GCTCAATACA TATTGAACTC CTAGGTGCAA TrCATrAATrr CATGAATTAA TGAAT17AACA CGCTCTCAAA G'1AGTGCT T1TCACAGA CTAGTCTTC TGCCT=TAA GCACTCAGCT CACCACGCTT CCAGTCTCAC TCCCCTATfA GTCTGATrAA AATCTGCTA CATGTGAGTC TGAGATCAAG TGT'rATCTCT TCTGAGAAGT CTCCCTCAC TGGCCCAAAG GAATnTCTCC TCTA'IIAG CACTGTCCCA GTFTGAcIGT CA'FrATTCTA GTCI1ITCA TATTAGTTGT rI=CATATA TATGTI'ATTA AGGAAACTAG TCAMFCCCC TAATAGAACA AAAITrGCTGG CCT1TGGGGT TGGCAATGGA GGGGAGGCT7C 17CTTGAAAA GGGGGAAGAG TGTTCTCCTA ATATITICT TACGAGA'ITr ATGTrGCTCA TCITAGCCT TrAGTCCCCC AT7GCCTGCC TACAG FrGGC AGAGACCATC TGTrCTcTCA CTGTCAGGAA CTGTCTCAAT TCTrGAAGTT CAGAGTCAAA AAAGAAGCAA G=1TCCTAG CTrTIGATC AA=ITCAAA GTITACTTC CA'IMGAAAA 'I=ACTAAGT CACCAGGAGA TGGTrrATAC TGAGAAATAT CCACTCATAC TCT7CCTCT7 CAACTTCIT CCATATACAC CCTATrACAG GGATATAGTC TTACTCTATA GCTCAAAAGG ATGACCCTAT CAGAAACCTG CACAGTATGT AAAACATrCT CACCAGAGGT TCACrrGTGT A1TTCCACCC TAGAATGGAA GCTCTACAAA AGCACAGAAT GTATCA=Ir AA='~AGAT TCTATITCA CACCCAGTGC ITGACACATG X1T7GAAGTT AATATITATr TATCAAGTGA 7rGTI=AAA ATCATGACTC ACTCAACAAA GTTATAAGAA TAAGAATAGT GI1TACAGAAT TGGTATACAC AAGCTGACCA TAATCAACAC ACCTA77ATC ATTIT=GC GACAGGTTCT CGCTGTCTCA CCCTGGCrGG AGTGGAGTGG CATGACCACG GTrCACTGCA GGMTGAACT TCCAGGCTCA AGCAATCCTC CCACCTCAGC CTCCCACATA GCTGAGCCCA CAGGTGTGTG CCACCATGTC CAGCTAAC= nI1AAITCT7 TGTAGAGACA GGGTCACCCT ATGT7GCCCA AGCTGGTCTF GAACTCCITG GCTAGAGAGA TCCTCCCrCC AAGGTCCCCC AAAATGCTGG GATCTCAGGC AAGAGCCACC ATGCCTGGCC ATAATCAATA CACITIAAG AATGCTAGAA TGTrATATCA GATGCATACT TCAGCACTAT CTCAAGCAAA CTGGGGTGTG GGTrATFCTA CATATAAAGT TCAGCAGTGT TGTrCCACAG TCCCAAACTC CAACTGAGGT CAAATGTAGG GTGCAGCAAG GTCACTGGGG CTGTCATCAA GGGCCTCTCC T7GCACT=T GCCAACCCTG 1T7CTGATr GTCTCTACCA CCATGAGTCA CCAGCAATCT CCCACAGTCA C'ITGITTrAAA AGT7CACAAG TATTGTGTGA AT7GCAGGCA ACCCCITGAC TCCCTGATrG CV]TGGTC'I1C 'rCCTrGGGC TCTACCA'TT7 7I1TCCCCA GCACTCT=C TGCTGCTCTA AAT1TAATr CATGCAATTC CATATGTGTT TCTCTATCAT TMrCATCTC =TCCTCTCC M~CCATCCA A=FTG'TrFG TCTGT 1TGCT TGCTTGCTG C'=AATACA T17CTCFlI I TCrGAGAAGG CT~rGAGTCCA AAACTCTCAG 7rACCTGTTG FTCTGTITCC CGTTAGflAA TCrCCGAACC TrCATAAArr AAATCTGACA AAGTCCCCTG ACTAACAAAG GAAATGCACA AGTCACAGTA AAAGGGGCAC ACACAGAACA CAAATAGACC CAGGGTC'= TCTGT7CATC ACTCAGCT= TTATAGGAGA TCCAGGAGAA ATGAAGTGGA AAGGGAAGTG TGITGAGTrFA CTATACAACA CAAGAGTAAA C1TCTrATA AGTGGTAATT TT7TTTACA GGAATAATTG AAAATGGAAA T7ACCTTCTC TACTCATAGT AAGTACTCAG TGCGT7C'17G ATGGGATGAG AATGTG=fG AGC'=AGTG TAAGGCAGAA T7TGMTAG TCTGCCAGTA 7TGGAGAAAA ATAAAACACA AAGGGACTGA CATGTAGGAA GTGGCACCTG GGAGGGTCTC WO 00/09525 PCTIUS99/177-12 trl-WU9 144 AATrCT1TCCT ATTACAAAAA TGCCCCAGAG AAATAAAAAG =TGTGTACA TGTrGAGATG GGAGAGTFFCT CTGG7CCCCCC TCGCAGGATG TGTGACAGTG GGGTGGCTCT CTGCTGCGCC ACCATGAGCT CAAACCCCTC ATAGGAGGGG GAGCACACAG GCAGGAAGGT GCAGGAGCTG GGCGAGCTCT TrGGGCTCTG GCCCCGTGGT ACTGTCTAGA GGTGGGTGCC TGCAACTCCT GAAAGCCCAA GTGGGCATGT GTTACAGTGC ACT='~CAG C'=GCTGTC TGCAGCrTAA GCGTTAACCA GCrCAGT17C TT=~GGTAC CCAGGTCCI7 GTCTGGCATC CAGGAAGAAT CAGGTTACAC ATGGACTTGA AGGATGAATG TGGGAG7IT ATGGAGTGGT GGAGGTGGCT CTCAGTGGGA TGGATGGGGA GCTGGAAGGG GGATGGAGTG GGAAGATGAT ATrCTCCTGG AGM~GGCTG TCCAGCAGCC GATCTCCTCT CCAGTCGTCC CCAGCCTCTC GACGTrCAGA TGCTCCTCT CTCTCC'ITCT CTGCCATGCT GTTCTGCCGT TCATCTGCCT GTCTCTCrCT GGAGCCTGGA AT 1TGGGGTT TATATGGTAC ACAATAAGGG GCATGGCAGG CCAAAAGGGA ACTITIAGG TGCAAAAAAC AGGAATGCCT CTCTCACI AGGGCTATAG A=IICAGGC T'rGAAGGTGG GGCCI=ACC AGCGAACCTG TAMCCCTG TCTCCTGTGC ATATCAATGT AATCAAATAC TGGGCTGATC CAGGATG=T =IIAGACCA ATTATGGGTA AAATAATA CATTCAGGTT 'TrATAMrG CTIT1GTCAT TrCrTrAA GCAATCATGT AAAATATCTA TACGACAGTA ATAGATGATA GCGAACCTAA TrAAAATTAC CAGAAACT17A AGAATCTCTA ATGA'I7rCAA CTGTAACTAA GG FrA TCT CITATG ITG AACAATGTTG GGAGATAAGA CACAAGAGT7 TCTGAAGTAT TTCAGAAACA CAAAGAGGGA GGTTATATAA ATAATA=Ir TTTCCTACrr TGGGAAAATG AAAGCTAGTC ACAAAGTrAA ACGAGTGGYTT ATITAATAT 7rAAAATACA GG=rGGATG TATCCTGT TAAAGAAAAT AAAATGCAGA ATAT7CAAAA CGTCrGACCA CCCT7CTAAG AAAATGCATC TCTGAGGTAT =mCCTrAG AAGTrATrGT AAAAATCCTG GAGAAGCTTG AACACAGCAA AGCAAACAGG ATGCAGAG11T TAATCTGTGG AAAGCITAGG GAAGAAAAGC AAATCATflAA AAATAGGTCT TCCTCTGAAG ATI=rAAAA CGCAAAGAGG GTGGAATAGC AATGATAATA AAAAAGCTGG CATAGAGAGT GGCACAKT1 GCTGTGCCAC TGAGCTGACT GGATGTGT7C TGAA'ITCTA GGCATrAGTG TACC1TCCA CACGCATTCr CCCI=AAAA AAAATGCCCA CACACTGAAT AC'TTrCA TGCAA'TrAA AATAAGCGCA CCATCTAGT7 TACAGAAATI' CACTAGAAGT TA TrATCCT AAAATAGCAG AGATCTAGAA GAATI=GAG CTCTAGGACA =I~AGACAC ACAGAAAGAA GAATCTGGAC AAGTCFTGAC CAGACATGAC AGAATAGAAA '1TCT=CC TATI1ATCTC 'TT7GAATAAA A1TICAGGA TC17ACAGTG GACAAGTrG TTATCTACAC ATTGTGAAGC ACAT7GATIT CTCCTCTGTA GC=TAGGAA GATCTGAGAG GTGACTGAGC TGAT7GAATG ATCCGTGACC GCTCTACTGG GACCAGTAGT AGAACTrAC TGGTGGAGAC CTGCTGGAGG 'TrTGAGAGCA GACI=GAAA ATTACTAGAG CTACACAGAT ACTGTGTGGC TAACrGGATT ATG'IMAGAG GCTICAGAA CTATGCTGCT GCTGCTGCAG TGTAGCCAGG ACGCACAGAG AACATCTrAAG GCTCTGAAT GGGGCGATAG GGACAGATr7 CAGCAGCCAT CTGACT'rCAG TGCTCA'IT GATGCITCC CTGCAGGGTG CAGTGTGCAG TGTGCAGTGT GCAGTGGTGG GAGGCTrCACA CAGGAATACT TGCTTCTGTA GCCCTAAMT CCGGTTCAAA CTCrGCATrC ACCT~rGACAG A T=CCT TGGCCAAAAT TI1AG'ITAGGC 17CTGGGCM TCTCITATGC CCACCTGCAG AC1T1TGGT AAAATCCAGT MFAGTAAAG AGCTCTGCTA AGTCAGTTTA GCAAGAATCC CCACCTCAAA AGTCACTATC TCCCTCCCTG GTAGTGTCTG GCI1rGTCTTC AGCGAGAATI' CTATTAGGTT CrGTrAGATT AGAATCCTCC TrACCCTrGA TGCTTCCTCT TAGTATITI TCATCCACTG ACTCCT7rGAC CCACCTGCT CCTCGGCTAT AAA'1TCCCAC TTGCCCATAC TCTGCAGTrA AGACTATTT7 CTCCCCACTA CTGCAAAATC CCATTGCCAT GGTCCCTATA CTATCTCAAT GGTAATGAAT AAAGTCTGCC T-rACCATGCT T]rAACAAGTA ACATTGAACC AnTTTCT TI1AACAATCT GCTGCACAAT GAGATTACTA AAA=Tr~I CCAT1TGCC ATGCTGGATG TCCTCAATGG AATGGCTCT7 GTGAGCACCA AATCA'ITGTG AGAAGGAAAA CCCATCTCTr ACAGCCCCCr GTAACGTGAT GTATGTTACA TGTGATGTAT GTTACATAGT TITflTCAT GTrGATCACT =IrGCCCAT TICCTrATAT CTTATCAGTT GGAAGACTGT GGAAGTrrGT AGTACTAAGC CACAAGATGA CTAAGAAGAG T7GAAAGGGC AAGTGGGGCT AAAAACAGAT 1TrGn7~GAC ITACCCCACC A'ITCCCCCTA TCATGGGGCT GAATCTGCCT GGAGGAAGGA GCATCITAT CI=GTACTG TGAACCACAC AGTCTAGCAG CAGCACAGCC AAGGCACITG GGGTCATG AGACTAAGTA CATGCAATTC TATrGTAAAG GCTFAAAATA TATACAACTG ACCCTTGAAC AACATGAATT TGAATTGCAT GGTCAGTrAT ACGCAGAT17 TCTTCCACCT CTGCCACCCC TGAGACAGTA AGATCAATCA ATCCTCTrCC TCCTACTCCT CAGTCTACTC AAAGATACTT GAAGTCTACT TGAAGATGAC AAGCACAAAG ACATTrATGA TGATCCACTT CCACTTAGTG AATAGTAAAT ATGTTTCrC ITCCTCCTAA ITITIAACA CTIC=CTC TCTAGMTAA TTTATTGTTA AGAATACAAT CTATAATACA TATGACATAC AAAATATGTC TT7AGY7GAC7 GnrrATGTrA TCTGTAAGGC TrCAGGTCAA GAGTATGCTA TTAGTGGTrA AG=rCGAG GAGTCAAAAG GTGTATGTGG ACITCAACT GCAGGGGGGT GGGCACCCCT GCCCCCATGT TG17CAAGGG TCAA='~AC TGCCAAAGGC AAGCC'=AC ATCCACITI TCCATCCCAT CAGTAAATGG AAAAAGATAG CTACAGTATC CCTGCGTCAA ATCTIT1TF TrGCAGATCA CAAAT7GGCC ACTCACCTTG CTCTGTGAGG GGTAAAATGC CCCACITCT TTAGTAATAT 'FrAAcITTAGA TAATATIAA G'TrATAAAGT TGT-C1TGT AATCGT7AAT TGTAKTIT ACATAGTf7C MrCAAACAG AAATAGCAT7 TT7G7TAGAT AACCITCCCGT ATAGATGATG AAACTCCIT TAAGGGCTAT CTGAATITA ATCTTGAA AAGGCAGAAA TTGGATAGCT AGTAGTCATA AATGTACTGT GGCTTCCCCC AACCATCTGG GCTATATAGA AGCTGCATCC TrGGACTGCA GTAGAGGAGT CTTACAAAGC ACAGAGCAAC TTCTCTCCrG GGTrGCGCTA GT7ATGATGG CAATITAAA TGTGTACTT TACCCAAAGA AAATCCT7AT TATCAACAAT CACAATGCCA TCATAACCAT GGTATAAAAA AT7CAAAATG TCCCAGCTGA AGTGGAGGCA AAGAC-rCAAG TCATGGAGT CAGAGTI1CC TTGCTAflCC TCTrITCAA ATGACCATrF AGTAAGCACC TGiAAGAAAAT AOrATGGACG GCATrGAAAA GTGAAGATAG GMTAATCT CTCGAAAATC TAATI'CTCCA GATGAAACGC TGACACTTAT CCACCCCACA GACCCTATAG CAGATGTGTC ACTGGCCATC ACAM~GACA CAGAGAAGTC ATAACTCAGT CAGCACAGAG ACAT=CCAT GAGTICTGA ACCATGGACA GAACGTCGTC TGTGGGACAT GAAAACTGGA ACTTAGAGGA CAGGCACATC TGAGAAATGG GCAGTITAAA GGCAGAACAT AGCACATATG TGACrGGG'IT T7AGAAGCAA A=IACAAGA CGCACT~TrC T'rCATCCTAA ATAATCTGCA ACCAAAG=T CCAAAAAAGA CAATIAGGA ATGCAGAGGT GAGGAGTAGG GAGGGGAATG GGATGAGAGA GAGTGGAGAT TAATGGTGGG CAcIAGCGAGG TfrAGAACfFr AGTGGTITCT TCAGGTTCTG AACTGAAArr TGTATACTGT AAAGGCACAA ACACCATIT TAACAAAAGT GAGCAGGACT TCCTATCTGG TF7CAGAAAAT AGGTGAATAA ATAGTACGAA TTATrAAAAA TAATAA FITC CACTATACA TAGGAAACT7 GATAGGAACC ATGATAAATG CITAACTCT7 AATMTCAAG GAACTCTGCT AGGGATATAA TATTATAAAT CTTG'IIGC AGATGGAGAA ATTGAATIT AACCCAAGTT ATCATAACCC TFAAATGATr AAATGATACT GTrACATGAG AAAGCTGCGT ATCTGT1CC TGGAMTGTA GCCATAAT,1T GTGTCTCAAG TCCC=ITGC TGCCAGCTAT CrrGGcITAGG TGTGTTCCCrT FGGGCTGTT TGATACCCCC ACA'17IATCT 'I II IIITTC TCTITr=G TrGAGAGAGT =XTCCC7GT TGCCTAGGCT GGAGGGCAAT GGCGCGATCT CGGCTCACTG CAACCTCCGC CrCCTGGGTr CAAGTGCTTC TCACGATTCT CTTGTCCCAG CCTCTCTAAT AGCTCGGATT ACTGGCATGC ACCACCACGC CCACCTAATT 'FrGTAT=r AGTAGACAAG GGGMTCTCC ATG'TGGTCA GGGTGGTCTC AAACTCCTGA CCTCAGGTGA TCTGCCTGCC TrGc3CCTCCC AAAGTGCTGG GATTACAGGT GTGAGCCACC ATGCCTGGCC CCAAA T1AT CFIAATGCC CCAAA7TATC TAGrrCCCAT GACTGGGC= CTGCTTGAT CCI=CTGCA C=GCTGGAC CCTCTCCCTG WO 00/09525 PCT/1US99/1 7712 tri-IU9 145 GGAAATGAGA TGTGTCCTG AGCCCCTAGT TAGAGGCTAT GTCTCTGCTG T7CCTGAATG GGCCTCCTGG ATGAGACCTC ATTAAAAGTC TAAYrCTCTT GGAGAATTGA GAGATACCTA MrGTCTCAA AATCArrGAA ACCAATTAAT GTATrATGAG CCTCTATCCA GTGATITGTA CC1rCAATrCC CCAATCCAGC TGTCAAGGCC AAIT~GTTCT ACCTACCTA GTAGGTAAGT CTGGAATrGT AGCTGTGGCA TI=CAGTAA TGGTACTCTA GGT7AGCAGT CCCCAACC1 'TTrGGCACCA GGGACCAGTr TTGTGGAAGA CAAT"IICC ATGAAGGGCT GGGCAGGGGA GTGGTITCAG GATGAAACTG TTCCACCTCA GATCATCAGG CATTAGA17C TCACAAGGAG TGCGCAAGCT AGATCCCTCA CACATGCAGT TCACAATAGG GTGTGCACTC CCATGAGAAT CTAACACCGC TGCTGATCTG ACAGGAGACA GAGCTCAGGC AGTAATACTC ATIGCCTAC CGCTCACCTC CTGCCGTGCA GCTCAGTYTCC TAACAGGCCA CGGACCAGTA CTGGTCCACG GCGCAGGCAT CAGGGACCCC TGflGCTAGG TATAAGCATC TGGCTGCTGC ATGTCT7CTG TGTAGCTrACA TCTGTATGTG TATCTGATGA GATATAAATT1 A TTGATTAT AAATTACTrT CTFTCATA'T7A GAGTrGTGAA TGAGTATCAC ATATAATTAT ACATAAACTA GGAATATGCT T1TTAATAAT GTATATAAGT AAGTfrCCTT AACTATGACT TTCATCT7AG CGTAGTAAGA GGGTGCTrAAG AAATATITGT GATGAAAATA GGCAT1TGGTA GAGTTGAGAC CACTGGGTGA TGAAAGAGTG TAAAGATIT AAAGCCrTCA GATGCTGGT-r CAAGGTGAGA AATGTGATTG GGAGCAAATC AATrAACTTC T7GAAGTC77 ATAGGGCAGT TATGAATACT TAATGTTAAC ATATGTAAAG CTCTI'CrGCC CrGTATACAG TAAATGCTAG TF7AGCTATTA TGATCACTAC TAAAATGGGG ATGACATAAA CCTCATAAGG TITAAGTAT TATGCAAGAT ACTATACAAA GTCCAGTAAA TATCACATTC AATTGAATCC ATGATGTCCG ATTA1TIAG CTACTTCCAA GAGAGAAAAA AATGCTGTCA GTITACTGT TM~ATAGAG AGCAAGGCAG ATCCCAATTC CCAATGTGGT AACGTGAAAA TMGCAT7 TGAATCAACA AAACA='~C TC= =r~r CCTACTAI7r AACAACTGGT AAGTCTATAC TCCCCCAAAT CTGGAATrCT C==ICIAT TCTIT=CCT CCTACCAAGA CCGCAGGATC I=rACTrGG CTATAAGGGG TAAACCTCAA GTAGTACAAG TrCTrCrGTAT TAC7ITATA CTCTGTCACA GATrCCC'= Gn7TCCTCAT CTCCATGTGA A'ITAGTrAA AT7CCAGCA TF1CTGATCCT TACTATACAA GGTAAATGAA TATAAAAACA AAACGAAACA AAAACCTCTI7 CCTA'IT1ACA TAAGGCCCCA ACCTAATATT TAGTGATATA TAT7AATGTG AACAAGGAAC TAACGAAGAC TGGGAAGAAA TTCACAGACT TGAGAGAAGA AATGGCAGGA T7CCTrGGGA ACAA'TrTCAT GTAACGTCAA AGGTGGTAAA AGGTCAAATA GAATGAAGAT GGAGAATACC GGATCTF ACAAAATGAT fTCCCAGGAG ATUTCATCAA ATGCACGAGG ATACCT17CTC AG'1CACCT AGTGAGTAAA AGAcTGGTAA CATAGCTCAC T7ACAA'IMG GATAAACAAA ACTAAACAAA CAACATCAAA AT1TrCAGAAA AAATAATAGC AAAACAGAAA TCAAACACTC AAATTF=GG TCCTrCrT'T TAM~CATT7 TGGATACTCA GTGAATG17A AI17AACCAGG AAACTTAAAA GTlA=ICAA TTATGAACCT C=CAATCCT TCATCAATrA 1TIGAGTAT TCTGGTCTTA AAAACATCTC MTCTAC AAAC=CTGA AAGAGATGAA CACCTCCACC TACACCAAAA TAATGTGC'IT TGCTGGCCAA AAGTACACGT CCATI=rAC T7AACAGTCT AAGGAAAGTC TGGTGCAAAT TACTATAATA ATCTGGGTTG TAAATGGTI CTGAGGTGAG AATGAGATCA TATI=ACAA AAAGTTIC ACrACTrAGT ACAAGCTrAC AAAACTCAGA CCACTCACCA GAAAAAAATC GGCATI17ATA TAGTFTGTGTT ACTITGGT7 TCCTGCATCT 'T7CACATCT GGCTCATI1A CATCAT1TC TrCATCTTCC AAAGTGGAGT TAGCTACTAC ATTAGGTAAG GTTACTTCAT CAATCACCAT ACTGUTATAA T=~GAAAGT GAAT=T1T GGACCCTCCC TFrGAATGCAG FrATACCrAG TAAACCTGAT CCACAACCAA GATCCAAGAC 1TIT1CCCA GCAAA1CA CTTGGC=T TGTGAAATAA GCCAGGAGGT CAAAGGTACA T7CCCAGATr TI7AAGCCTC CCTCATAAAC ACCTGTAATC AGATCAGAGT GAGAAGAAAA GCFTTTGAA ACTATGTIT CTCCAGGGAA GTTCTCTTC AACAAGATGG TITCACTAC TGATAACTrA ACATGCTGGA AACCTGGTAA TG=CTTATG ACI=ATI= CTAACATcTr CITAAATCT rTAGGCATAG CATGCTC'= GGCAGCTCTC AAGGAGGGCT G=F~CCATG TGGCTCCAAG T7CCTGAAC TGCTGGCTGC ACTGAGTGGA CTGTCTGTGT =TGAGAGGG AGCTGCAT17 TCCATrGACT TATGTlCCCA CAAGTGATCC TGAGGCAAGT CAAATrGTrC TGCAGAACAT TI7CGTCCC TCTC-CCC 'r=GACrr TCTGAGACTG ACAGCT='~ TGAGGAATCC AGGGTCAAAG CTCCATCTCr AATGGGTGT-r AAT7CATIT CCAGATGGTC TCTATAGTG AAATTAAACT GAAAGGTCAT CCTCrTATrA AATGCACACA AT=T1AAAT TCAGA77C1T CAACTCTGG ATAGAA'I=G ATGATACACA CAAATCTGCC TCAA1TAT7C AATTAGTIT GTrGGGCCCA ATTTCT=r AGCAGC'ITAT ACATGGTAAC AAATAT17AG AGATA1TCC AAATGACI 'TrAGACGTC T 'FGGTCCTCT T7CCAAGCAG CTCTGGAAAG AAAAAAAAAA AAAAAAGAAA GAAAATGATG ATrAAAGCAA AATGGCACAT TTCACTAAAG TGTAATATTA AACAGCCACC CCCACCCCTC CCTGTCCCAC CATACAGCTG C1=CTTA AAAAG17GTG GGGAAGAGAG AGAGATAAGA GAM~GGACA CTCATACACA CCTI7AAGGGT TCCAAAGTGG GAGAAGAAAA TCAACTATAA AAACAAACAG AAGAACAACA GCAACCACCA CCACTACCAC CTGGACAAAC ATAAAGTCCA AGATATTCAG ACAGGACAGC CTAGCTACTT GCTGTC1TC AGCTGTCTI'G A'TrrGTGTCC AACCATATTC ACCCCCTAAG CTTCCAGAAT AACITCACYT CTGTCTIIA CAGAAGAGGT GCAGTA=TI AT1TGGTAA GTCAGCGTCC CITAAAAAC ATGCATAGGT ATGGCCTGGT GTGTGTAAAT TCATCCAAGA C'FCACTCCA AACAT117AGT CGAGAACAGC AGCCCTAAGT GTATAGAAGT GGGGGTAATT TGGCAATAAT TAGTAAAGAC TAATrCGGTG GCAGAGCAAA CGCAAACTAG GGCACTGCAG TAGTTTGGAG AGACCTGTAG AAATAAGAAG CAACTTAI7 GAGAAT='1C TATCTACTGC GCTAGACACT ATACCATCTG CC7CAA7MT CACAG77CTG GCAAGTGGGA TCITGTrCC C=rATACAA GA ITACAAT TrGGGGGAGA GGCGGGTCAC CCAGTCCCGC GGCTAGGAAC GCGCCTCTI CCTCTCCCAT CACGCTGCAA GGCTrGGAGT CAcTTCCGGC TGCAGGTCCC GGAACAAATC CGACCCCAGA AGTGGGGACT TCTGGCCCTC ACCTCCCCAT TFGAATGTAA TGTTTACAGT GATCCAGACC TGGGGATGCT TGCTTCCCGA CGTGTCCTGG GATCGCGC= CTGAAAAAGC TCACCTCACA ACGCCTCCTC CGGACCTAAA TCGCGCACCA GTGAGTCGAG TCCTCCAGGG GCTAGAGAAG CCCGACTIC TICCGGCCT TGAGGGACCC GGGCTCACCA AGAAACCAGC CGCCCTCCTC TCTATGG'IT TGGAGCCGGC GGAGAGCGCG CAAGGGrrGG CGGGACTGCG AGTTCCGGT CrGGG=TFG GCGGGTCTGG T~GAAGCTC TCCTGnITGA CGAAAGTATG TCTCAGGAAG GTGCGGTCCC AGCTAGCGCG G~rCCCCTGG AAGAATTAAG TAGCTrGGCCA GAGGAGCTAT GCCGCCGGGA ACTGCCGTCC GTCCTGCCCC GACTCCTCAT ATCCT1rC=T1 GG'rrGTCACT TCTACCTAGA GAAGGGTGTG GGCGGGTCGC GAACCTICT MT~cTGTCCC TTCAGACCCA CCGCCAGGCT GGG1TATATr ACCGCGGCCT GAACCCCCTC TI= =TGT CAGTGAGTGG GATGAAAAGT GAGGGACTGG AGGGGAAGC6 ACAACCGTGG TAGAMTAAG TAAGGC'=G GCCCTGGAAA GCCTCGCGGA CGTG'TCTGA CCCAAGG T~r TAGCAGTGGA TGTGGCGTI7 TCTCCATrC CTTCTTCAG TITITGTA CTCGTG=T GCAATrAAGT GTAAATACTI' 'ITGCTAGTGG ATAATGGGGG AGGCAAGGAC TGAGACCTGC GGTATGACGA TAGCTCTGGC TCTI'AATAGT TTGAGGTAAA GCGAGATACT CTGAGCTIT GTCTCCCGTA AAAAGGGTGG TGAATATGAA TAAGGGCFI CTTAGCGTrA TAAGAATrAA AGGGCATAGT TCTGTGGTGT GAAAT=I1A AAAGATGTTC AGTAAATAAA AATGA'TTC CTCCTTCCCC TCTCAGACCT CTITICTC 'Irr=CTa TfFTfGAC AAGTrCTCAC TCCTCTCACC CAGGCTGGAG TCITCrGAA AGAGIrTTC CGCTrGITGT TGGCI=CAA CTGTrGGAT7 TGAGGCG=T AGCGCCIT7CT TCGTCCGGGT GCAGCACATr CTITGATTGGT CTCATGCCTT TGTGGTTGTA AATGTGCCTG GAATCCTAGC CT=CATGGT AAACCATATG TATATGTATC TITMCACAA CA=TGAGCC CAGCIrATA CAAT7ACACT CAAAAGAAAA AAAGTAACCT TCACTTGAGA GAATC1rCAAT ACTGCACAAA WO 00/09525 PCT/US99/1 7712 TATrGTGCAG CTAAAGCCCT ATGTAATCAC ATAGAAGTCA TTCACCTAGG CAT7AGCAAA ATCTCAGAAG GTGOCAAAGC CCCCITIT AGTITGTG TAGGTACAGA ACTGCCGTCT TCAAGGAGTr TCAACTrGAA AACAAATAGC CACCCTCAAA ACATrCAAAA ACACTrAAAC TGCGTGCATA ATGTGTGTGA GACATGGTGT TAGGCM~GG GAGAACAGAG ACACGGAACG TGATTCCTCT TCrrCCCCAC AAGCrrATAG AGAGAC17CA 'FrAAGTrGAA AGTCAACAT7 CCCACCTAGC 'IMGCACTrC AAACGACATA TrCAAAAAAG CCCAAACITC CTCTAGMIT =TCATCTGA GTAAATGGfl TCACAAACTG3 AAACCT7GAA TCCTCTUIrGT CTCACACACC CGATCAGTAA GTTCTA17GT T7CTGATrCC AAACTATGTC 7rGAATCAAT CCGT7ATCT CCATCCTCAT TGCTACCACT CTGA TrCCAA ACC=~ATCA CCTCrCACI1T GGAGTAI1AA TAG ITI7CCTr GTrCTACTC ATAATTCAT'r A'rrCCAAAAA AGTTAAGAGG GGAAAAACAT AGATCTCGTC A'I=CCCMT TAAACCACT TrAC=rCAA GGTTCCAGGT GATCTAAGCC TTGCCCT7CT CTCATACCTA GTF7AATrAAC TACACTCTGT TCATGAATAC A FJAGGCTCA CCTACCTCAA GATCTMTTG CTCAGCCTGA TTTGTTCTCT CAGCCTG CATATIT7CAT GTTATGTCT TGGCCCAAAT GTCACTTCCT TAGAGGGGCT TFTCAGAGC C1TCAATCTT AGGCAG~rCC CCCAAACGCA GTCTITACACT TGTATCACAT TGGCCTGT'TC AGTITCTAA AAAGCACATT ACCAT7AAAA GAAATGCTCT TGMITGC=T GTATATITIC CACTITCTACA CATlATGTF7G CAAAGTrCAT AAAGGCAGGA TGTTGAT CTITCACAGCG TTACCCTCAG CACCTAGAAC AGTGCCTGAC ACATAGTAAG CAT-fCAT1TAA AGGGCTAAAA ATAMICATG =TAAAAAT ACTI'GGGAGT CTAA'TrAGAC AATACTIMT T7CAGC=AA TGGTAGTA'T TFAGMTCAC TAMTTAACA AATGAAAAAT TrGCAATAAA TCTACAATGC CATTACCCCC CAAAATC= r CATGTI= GCATIT1ACG TATTATITC CAGGCCrAC CTGCATGTCT GCATAATCAT AACTGACTAA TGGAACA GCTGGTAAITF A'IMGAGCTr TACTGAAA'IT TCATGAG GCCAATrCTA CCCTACTGAA CTCAAA ITG AGTlAATGAT GACCTCATI1 TGATTGCTGC TGTAAAAAAT AAGA'IMCGG AAGAGGAATG AATTCTTGTA TTACTGTGGT AGGACTATGG G TIflTT GIT7G TTGT TrGTGAG ACGGAGTCTC ACCCTGTCAC CCAGGCTGGA GTGCAGTGGT GCGATCTCAG CTCACAGCAG CCAGGT~rCAA GTGAT-rCTCC TTCCTCAGCC TCCCGAGTAG CTGAGATI'AC AGGCACGTGC CACCATGCCC GGCTAA=T T F7GTATC'IM AGTAGAGATG GTITCACCAT GTTGGCCAGG CTGGTCTCGA AC7CCTGACC TCGTGATCCG CCTGCCrCAG CCTCCCAAAG TGCTGGGACT ACAGGCGTGA GCCACCGTGC CCGGCCGGGT TAT7CAT TCTUAlFIAAC A~rC'I=GAT GA'TC~rATG GTGTrGTTAC AGTAAAACAT TrCTAACAAT TA FFCTAACA ATTATTCTTG ATGGTGTATA TGAAGAATT17 A17GTCGTGT ATT7GTAAGC TGCTATG3TGC AGAAGAATr CAGTCAAATA AAG~FrGGTAA GATAGGTATG TAAGTAATAT GAAAAAAGAT AGAAGGTGAT GAGTGACTrA GGTATAAATT AAGTACAATA GAAATGTTGA GGAAAGAAAA AMMCTGTA ATAGAAATCG GAAGTACAAA CTGGGCATGG TGGTGTGCAT CTCTAATCCC AGCTCCTrGA GAGGCTGGTA TGGGAGGATC ACI-rAGCCC AGGAGCTGA GGCrGCAGTG AGGTGTGATC ATGTCACCGC ACTCCATCCT GGGTGACAGC AAGACCGT~T CTCTTTM 1TrTTTGA GACGGAGTCT CGCCTATGCT GGAGTGCAAT GGCGCGATCT TGGCTCACTG CAACCTCTGC CTCCCAGTT CAAGTGAT7C TCCTGCCTCA GCCTCCTGAG CAGCTGGGAT TACAGGTGTG CGCCACCATG CCCAGCTAAT TATTrGTAT ITAAGTAGA GACGGGTTCT CACCATACTG GCCAGGCTGG TCTTCAACTC CTGACCT=T GTrCGCCCAT CTAGGTCTCC CAAAGTGCTG GGATTACAGG TGTGAGCCAC CCCACT7GGC CCCGAGCGAG ACCCTCTCTC TAAAAAAAAA TAAATAAATA AATCATAAAC CTGTGGATTA TTGTAGCA17 G'ITCTCATC TGTCAAAAAT ATTCATGAC TATGCATAGT TFGAAAAGGC AAGTTGTCC CTGGGCAAT7 flCAAAATAT T7=T'1AATG TGTCACA ATACTGTFIA CCTAATAAAT CTFAAGT=T TAAAAGCAAA ATTAAGCCAG TAA'I=GAGT CCAATTCCAA TcIrcT1ATGA GTCATTGCT'r AAAMICAAA AGGGTrrAT TTITITA GG'rrGTTCT GAGTAATGAA TACCCTATrA CTATGATACT AGTATCT7CC 'ITAATrATCC TACTCATTGT CTCAACATTC TGACAGTrGG ATTGAGCATA T7CGTAAGTA AAATTG1TM1 AACTGTATGA TGTACTIGA TGTFAAGGTC CGAGTCCCCA CATACCTCGG TAGATGTGT7 =~ACAGT11 TGTAUCCCT TGAAATGTAA CTGTTCTCTA TGTTACAGCC =~ATAACCT TCAGT7AC'Fr GAAATGAACA AATTCATrCA AAT7CCAGCA CTrAAAAGT'r TTAAATrACA 'TITGGATAA ATACCAAAGT GT=TGTrGA TGATGTATGT ATAAACAAAT TGTAAATAT7 AAACGTIAGT TGTTACGATT AGACCTATAT AAAACATGAT ATGCAGTCTA CTGAATAGCT ATCAGCCT'CT AACATG=TA GTGTCATITA GAAAATGCT TCTAAATTGC CAAAAGCTGA ITGTCTAGGT GATAACAAAT TrACCATTrG GAGGAAGTrG ACT!1CTCAT 'TCATGTCT TCATCAGTCT TACT7GATGA GA77CATrCT TCTAGTCAGA AGAGAGiTTrA GACTGCTCAG MTACTCATA 'ITGAGTTA GC=ITCTAT TTAGAGTTCA CTGGTTGTG GAATA'rrCAT TrATAATTG AATCTACGT'T GTGTAATGGG ACCTAATFT 7=TCCM~ G'TITG'1G GAGTCTCG'r TTGTCACCCA GGTTGGAGTG CAGTGGCGTG ATC=IIGCTC ACrGCAACCT CCACCTCCA GGTTCAGGTG ATTCTCCTGC CTCAGTCTCC CAAGTAGCTG GGATFACAGG CATGCTrCAC CACGCCTGGC TAATITGT ATMTTAGTA GAGATGGGGT T7CACCATGT TGGCCAGGCT GGTCTFCAAAA CrCCTGAGCT CAAGTGATCC TCCTGCCTG GCCTCCATAA GTGCTGGGAT TACAGGCGTG AGCCGCTGAG CCTGGCCCCA GAGMT'7~ TGTITGTIT TCAAGACAAG ATCTCACTCT AUTGCCCAGG CTGGAGAGCA GTAGTGCGAT CATAGCTCAC TGCAGCCTGA ACTCCTGGGT TCAAGCTA TF CTCCTGCCTC CATCTITCTAA AGTGCTGTGA TTACAGGTCT GAGCCATGAT GCTrGGCCTG TGTITWGTT TGTITrGrf GGGGGACAGG GTCrrGC=~ GTCACCAAAA CTGGAGTGTA GTGGTGCGAA CATAGCTAGC TCACTGCAGC CTCCATCTCC CACGCTCAAG CAATCCTCTC ACCTCAGCCT TCCAAGTAGC TGAGACCGCA GGTGCGTGCT ACCATGCGTG GCTAAT1TC TA'TrTATATA rrrTrMT GGTAGACATG AGGTCT7GTC ATG'ITCCCA GGTGGTC'IM AACTCCTGGG CTCAGACAGT CCTCCCGCCT CAGCCACCCA AAGTGTTGGG ATrACAGGCG TGAGCCACCA TGCGTGGCAT AATTT1T= AAGTAAATTA mTITTATC TI'GAGTATAG AAGTGATrCA TGTTCATTGT GGAAAATATG AAACATATAG AAAAACAGAA AAGAT7ACAA AACATCTAAT CTGAAATGGT TAAGA TMTG ATGAGAACAG TCTCATCTCA 717CCGTATA TTCCTGCCAG CCTATCCATC AT7CTTCGTA CATGM~ATC TACAT7AAAA T7GGTGTrAT KITFGGAAA C'rG=T AACTACAT7G TGAACAMTI TCATG=ITA AAATGTCA IT ITAATGATGG CAGATCCTAT TCAATAGATG TACACACACC TAT7AACTG GTCCACAATT GTrGGATATG TAGGTCGTI CCTITCTCTC TTTrMT TITTGGCTA CTACTrAATA GMTCTCTGT ATAGAATGTG GTATrTGAA AGTGTATCAA GCMTAGATT GGTAGTATrC TFIGCA'ITAA TAAAGGGCAG TGGCC'IMGT TGACTGACAT GACAATATI TrATAAAATr TGTI7ATI17GC 7TrACAGAAA =1TGAAAAT TA'ITGTAGAA ATGTTAC CTCATATGAA CCACCTGACA TrGGAACAGA C'=CTC ACAAGTGTrA CCAAAGGTAT AATACrATfTA CCTGAAATA CATGT7ATAA GGAATCTAGC CTCAGTCT7A GATGAM~AT TA FTAA17AT GGCTCTC=~ 7rCTAATATA TCAAATATAT TCAAAATAAA AATAAGGAGT AAGTAGATCI' CATGTGAGAC TATAATGGTG TrAGTGTGAT CATTAGGCAG F7AAAAACTG T7ACAGGCTG GGCACGGTGG CTCATGCCTG TAATCCCAGC TCTCTGAGAG GCTGAGGTGG GCAGATCATC TGAGGTCAGG AG17CGAGAC CACCCATGGT CAACATGATG AAACCTCGTC TCTACTAAAA GTACAAAAAA 7rAGCTGGAC ATGGTGGCAG GTGCCTGTAA TCCCAGCTAC TTGGGAGACT GAGACAGGAG AATrGC'FGA GCCTGGGAGG CGGAGGTTGC ATTGAGTCAA GATCGTGCCA 77GCACTCCA GCCTGGGCAA TAAGAGCGAT GCTCCGTCTC AAAAAAAAAA AAAAAAAAAA AAGAA=TAT AITCAGAT TGTGTGGTrC CTrTACTAAC TGAAITTTAAA TTATTTGTAG TCAATrTAA ATGCTCTGT ATM~AAAGC CACTGTACTC CAGCCTGGGT GACAGAGTGA AACCCTTAAT TCAAAAAAAA AAAAAAAAAA WO 00/09525 PCT/US99/1 7712 EPI-1 09 147 AAGAAAAGCT GGAATATrGG CAAAATCAAG TAACTAAGAG AAAACATTAA AT-rCACAGAA TACATTATTA CA FITAGAT ATATATGGTA TATG=IICT CTGAAAAGCA CAAGCATACC 71T1TG Trr TAAATGGAGG GAACTAAAGA TAC'IMGGTG CCAAAATGAA ACATTATTG TAATTAATCT CTrATrGAAA TGGG'ITCTA ACTIAGCTT TGAATCGTAA T=rrCAAAT TrTTGTACr CATAGTCACT TGATGATrCT CTATCTGAAA TA'ITTAG AATTGflCT TGACCACCAG AAAAAGATrC AACTGTrACA TAGATGAAAA TGGATGTrGA GTGTTAACAG GCCTATGGGA AACAGTATI1 TCMIAGCTA CAflGTAflG TTGACTGTGT TGCTA1rC'rr ATAATGMIA GGTCA TI7AA AT7GT-rAGAA AGATCCAAGT A'JTAAGATCT AGGGTGGCTA ACTI=CACA GACAAAAAGC TrGTrrGTAA GGTCA'ITAC TATACCCITA ATrCAc3GAAG GTTAGCT-rGA ATITGGGTCAA AAGGAAACTG GTTAGAAAAT AAGTGAGTAG TGAATAGGCG AITCAGTGCA AAT-rCCT]rCC AGAAAATACC CTGTAAATG ACTGTATGAA TGTGGAT7CT TCAAGACAGT CAAATTTATT GTGCGAAAGT AATACITIA TITITGCAT CTrCTAAAACA TGAAC=rGA GTGMTr AAAAAAATTG ATGCTATTAA ATAGATTCAA ACCATAGAAA TGGAAAATAA AT11CTG'TTT GGGGC'IIG GGGGGATrAT GTrGTAAAAA TACCI1TCT CTGTAT1TG TGCTAAflA GGTACAATrG TrAAGCI'AGA TGATAGCCTG TGGATGT7AC TAGTGCAAAA TCAAATTATC GTATrGTGrr T7CTCrGTAA AGTITGTCT TGTQ1TcT AGTGATTTCT CTrATrCCTG TTrATrrA=r GAMIGTI= TACAGACI'GT GAAATT'rC GATGACATGA TGTATGAATT AACCAGTCAA GCCAGAGGAC TGTCAAGCCA AAATIGGAA ATCCAGACCA CTCTAAGGAA TAT1TACAA GTAAGTCAAA TGTATTAGAA AGCAGGAGAG AGAGGGAGCT TAAAGAATGT CAAAAT=1T ATACTGATAC TGAT~rAGCTA TGTATrCTrA TGTAATGGCC TAATG F7GGA ATrAAAMTA TAGAA'rrAAA GACGTGAATA TAGAAACATG AATrCTGAAT AATAAACTCT TATAAGAAGA GAAGTCATCA AGCTAGCTGA CCCTACCTGT AT1TCAAGG ATATGTGTGG AACACCrGCC ATGTGTITG AAGTr'rGTGT TAGTATTCrA AATGGCTAGA CAG FrGTrCC AGTATTTGTA G'rTCTGATAG ACTAAAGfTrC TGTGAAAAGA GGAAGAGACT GTGI=rGTr CATrGCTGTA =TGTAGCAC CCAGCATGCT GACTAATACC =IrCAGTGC ACAAAAAATA TATTCTAAGT GAAAT=CCT TCCTrATTCA CAGACAATGG TGCAGCTCT7 AGGAGCTCTC ACAGGATGTG TTCAGCATAT CTGTGCCACA CAGGAATCCA TCA FTGGA AAATATTCAG AGTCTCCCCT CCTCAGTCCT TCATATAATT AAAAGCACAT TTGTGCArrG TAAGGTGAGT AAAGGTCTAA TTATACTIT7G AATGGTATAT AATCAATGTG CATAGGGGCT GAGTAAAATA ATGMFGTAT AAGATITAC A=IAGTCT ATATTA17GA AATAAAC'= TCCATAGAAT AAAGAACATG TAAGTAAATA A17GTTGCAA AAAAAGTGGT ITIAAGGAAG TCAITFAAAAG TGGCTTTTG GGG'TT]TA GTI=ATC'Fr ATTrCCCCrC TATAAAGAAA GAAGTITAA GAAMfGTGT TGAGACAGAC ACAGGGATCC TGAAATAGTrT ATGTCATGTT GCATTGACCA ATA FrCAATT ACCATTATGA TAGATGTCA GAACTrCCITr 7rATAAAGGA AAGflAATCC TTA'I=AGTC CATCTCTACA TGCCAGAGGT AGCCTrGAGG CACAAAAGCT TGCCrAGAAT 'FrATGGGTCA CAGACAGTI1 TAATATrGCT A'Tr7GTrGGG CGAATGAAAA TCACTAGTTA ATTAATACCT CTC'TGCTG ATAGGATGCT AAAAATGTCA CGCACCTGGC CTAATGT7AC CCTITITAG TrCTGTAMT GCAAGATCAT GGAAGTCAGA AATAATA1T1T TATACATGCT TGCATCT=T GAAGCACACT ATATrAATG GATG'ITCACT AAACAATGAA TGAATATGTG AYrCAGTAAA ITATGATCT CTAATAGTAT GAAT-FAAAGT AAATTTGGCr CTTGAGC'= GATI1rG= TI~rCTCrCAr TATrrATC CGTAATCAGA ATAGTGAATC TGTGTATTCT GGGTG1TTAC ACCTAGTTTC AGACCTCC CAGGCTrT= TCAAGGAGGC CrTTfCTC77 CAAAAGCAGT TAATGGAACT GCTGGACATG G'I=GCATGG ACCCI=AGT AGATGACAAT GATGATAMT TGAATATGGT AATAGGTGAG TGAAGAAAAC T'1TCTGCTrA GTATATGGTG ACTATAAATC ATGTATCAAT TAAAATrGTC TCTAATGATT CATGTT1AT11 TCTACTAAT TATGCATTAA AATTGA'T7A AATCTTACCA AATAAA TTT TAATCT1rGAA A'ITTGGAATr TGTAAAA'IM ATIT1GGGTA CCTrAACCTA GATI1GCGTA '1AGTTACT GTAA'TrCTC CACAATGATT AACrrATATA ACTIATAAT CTCTGAGGTT GTCCATATTC AGAGACAATA ACTICACAT TITITAACC ATAACTGATA T1rGAGATGCA GTrrATATI1 CCTrCCAGAA TACATATAAA TACGTGCATA TGTGTATGTA AATATGTCTA TTCTCATATA CATA TATAA TGAAATAACT CA=1IACAT GTGATGCACT TTATACTAGT TrNAT=AT MFA 1TAT 'r=TGAGA CAGAGTCTCA CTGTGTAGCC CAGGCTGGAG TGCAGTGGCA CAATCTrCGGC TCACTGCAAC CTCGCCTCCC GGACTCAAGC GATrCTCCTG CCTCAGCCTC ATGAGTAGCT GGGATTATAG GCGTCCGCCA CCACACCTGG CTAATITG TAT=1TAGT AGAGACAGGG 'ITCACCGTG TrGGCCAGGC TGGTCT-rGAA CTCCTGACCT CAGGTAATCC ACCTGCCTCA GCCTCCCAAA GTGCTGGGAT TACAGGCATG AGCCACCGTG CCCAGCCAAT ACTAGT17AT T1TAAAGAA TrGCTGGTCG TAACACACTT CATrrGA=rr ATCACTCA'Fr AATGGA'ITAT GAACAAGAGT rGAAAAACA ATATAAAGGC AAAGnrTGCA TTCAAAACTT TGGTATAAAG AGAGTAAGTI7 GG1TIGTGC AGTGTATCAG GCACCTG7TG CTCTGCAACA CACCACCTCA AAATCTATTT AITCACTATT TATITATTCA TGA'FrCTGTG AGTCrGCAGT TAGGGTGGG ATGTCCTGAG ACAACTFCT CTGATCCACC TGGGGCACTA GCTCACCCAT GTGACTCAG TGACI-rCAT'r CACATCTGGC TGTTGGCAGA GGCAGAAGTA CTrGAGAAAG CCATGTGCAT CATCCAGCAG GTTCACC~TA TCTCAGATAC CTGATGCCAG TGGTITCAGG GTrCTAAGA GTAGCAAAAG TGTGAGCAGG TCGCTrGTGTG CTAGCAC1T TCAAGTTrCT GCITGCCTTA ATITATrAT TGTCCCCCGG GCCACAGCAG GTCATAGCGT 11TAGCCCAGA GTCATTGTAG AAAAGTGTGG A~rCACAAAG GGCAGTCATT GTGGCCATT TTATAAATAA TCTACCACAG ACTGAGTAAA AGCCTrGCAT GAATACCATG GATATTAAFr TGAATr~TrC CFTTIAGAT TT7CF=CCT TAGCAATI1G 71TGTCATF TrGGAT7AGA ATTATATCTG TAGAATA'IT CAGTTATAAT AGGGTACAAC TITATrCCA CTGAACATCT U'AG=IAT TTAGGTCATC TGGTAGGTAT AAAC'ITCAGA AG1TrAATATr CAATAMrAT AAAAACCATr AACAAGTGTG ACACTTAAAT AGITIAAATA ATTC'n=GA CACAACTGTT TCCAAGITGT GTTACGTATr TrAATTCAAT CAAATGT7GA AATrGTTCAG TAGATAGM~ TAATTATAGG AGAAACTCAC CCCCATGACA TI7rGGATGTC TrTAAAAGT7C TGT7ATCW CT=GCAGT~r ArCArrCr TAT7GGATAT CTGCTCrT I ATTrCCAc3TA TGGACCATGC A'TrCATGCC AATACT~rGGA AGTIrATAAT TAAGTAAGT7 TGTTrGTTAT TTMACT rrAGAAAATG T=~CCATAT TCCCCAATCT TAAUrATlCA TGATTCIMfA GATTGCAMI AAAACA'1I1 GTGTGAA'IM AATG'rCACr GACACTGCTG TCrGATAATC CAGATAUTCT ACATGTAGCT CTCAAGCCAA ATTGGACTrC I=ACCCTrGT GGCCTCTAAA ATrAAAAAAA ATGTTCTrCC TAGTrAGCTrA GTACTTCAGA AATAATGGGC CATGGGCCAG ACTAGAACTr AACCACITIT CrrCTGCTAC TGrG A CCAGCTATCA AGTATCCTAT TFCTAGGATT AGATAAATTG ATAACTATAA TTAAAACTGA ATATAATCTT TTCA TrAGGT AC1T1AAGT TGTTCACACT TAATTrCCATT TGTACAGTAA =ITAA=1T CTGAAACTGA AGCAT1TAA AGGGTCACCA GGGATAGTGC CTGTAGCAT7 CATCAGATI'C 7rAGGGGTGA GAGGAGATGT GGT-lGAGATG TAAAAATGGT TAAGAATATC TAC'1TrATAC ACATACATAA AACATTAAAG GTCAGTGTAT 'IMCAGGTCT TAGGTAcI= TCTrGTACTA CCAGGACATT AAG77GCCAT TCAGTGGTTA AGAGTGTTGC CTGGGAGCTG TATCACATGT GCTTAAATCC ATTCrGAAA TCATITACTC =~CTGAGCC CT]7GGGCTAT TTGGT-FAATT TCTCTGAACG rAGrrCr CATCTGAAAA TGGAAATAAT AATAGCAACT TCI1GACAGG GTrATAGTGA GAATrGAGTT CATCACTGTG AAATGCITAG AAATGTGCAT GACACATAGT TAATACTCAA GGAATTAGCC ACATCACTAT CATCATCACT GA FTATCTC CACTC'IACC CTCTrCCAGT TCA=rCTG CCCAGCAGAA TGATMTTIA AAAAGTAAAT CAGATCATGT TACrCTATTG CTTGAAGTCT ATCCCA7TG ATrAAGAATA ACAACCTAAT CCTCTGTGGA TGCTGCCTCC TTCACCAGCC WO 00/09525 PCT/US99/1 7712 EP'I-109 148 TGTCTCATGC TGCTCTCCCT ACTCTTAGTF CCTCAAACAT ACCAAACTCT CCTGTCCCAG AGTCrI=CG TGGTI1TCC ATCTrGCCTAG GATGCTTCTC TCTCCTATr TGTGTACCTT GCTAACTCCT GC=ACTGTC 'TrTCAGTrCT CAGCTrAAGA GTTATATCTT CATGATAACA 'FrCITGATA TCCTrACCCT AAGATTAAGT TAGATTGATA TCCTrACCCT AAGAATAAGT TAGATTAGGT CTCTCTA77G TAGCACCTTA GACTCTGTCA 'FIGACAAAT CACAGCCCTA A FTAATTATT CTTAAAATA 'TTAACATrC TC TCTCATGC TAGACCACAA GT[rCATGCA GGTAAGGCGG AGAITGTGTC CAMTrTrrG ACCCCMTGT CTCCAGGGCC TGGTAGAATG CCTCATACAT AGTAAGAATFT CAATTAATAT TTTACACAGA GAAAAAA'ITA GCAACTrATT TAAACAAATA TAACTGCTC AGAGGTAAAC TGGGCACATC TTAGTTATAT TATGTGATAT ATGATGC'= TTGATTG1Tr TITAAATGT TCTACAAGGT AGATATrGTT AGAGGTCCTA AGTrACTTGA TGTGTrACTT GTGGTGAT7G TATTCTITC TITATTCA ThrAGGCAGA GC=rAAGCA CCAGTCCATA ATAAAAAGCC AGTrGAAACA CAAAGATATA ATTACTAGCTF TGTGTGAAGA CATTCTT1C TCC=CCATr CTGMTACA G'ITAGCTGAG CAGATGACAC AGTCAGATGC ACAGGTAAAA TI1GGGCTAA TAGCA=IIA AACAGCAACT CTTA IICT TrGGCAGT-rA GTAAATCTCA 'I1TGAATGTC TGGGTCAGTC TAIT-AAGAG GA'IrAA'rr TA'1CAMr GGGTGTTI =ITGATCTG TGGGATTT~ TATATCCCAT AA FrACTIT CACCCAGAGC A ITGTATTAG ATrCCTAACT GCTGTCATTG CC~rCTGGGGT CTGCCTGGCT CCCTCMTGC T7GGTAACrG G'ITGGTCACA GCA FrCITCTr CAGAATCCTr TCA TTC=1 CTGCATGAGA ACAAAAATFC =FTGTTCAT AMTGTATAA GATCTGATAT AGCTGCAATC AATCT7GCAT 71ITCT7CA CCAACGCATT GCGACCTPA GGGATACAAG TATGTTTGTG CATGTATATG TATGTATCAG TCTITAAAT ITGATATAGT CATACA=IG 7=1TA=FT GAAAAGTrAG AGTGTrGAAT TGGTATCCCA MIIATGAAAC ATTATATTCT AAAAATrGT AGTACGATTA FTGGGAATrA TAACTCAT~ TCCTrGTAACA CTGTrATACA TAGTACCTT TGC'=CAGA CTAGCCCTCA ATTIATIA ACTATAGTAG TCCTAAATTA TAAGATrAAT AGTACTCAGG ACCTAACAGT TATATGTCAT 17GTmTT= 71Fr=GAG ATGGCGTCTC ACTCTGTCAC CCAAGCTrGGA GTGCAGTGGT ATGAC=rGcJ CTCACTGCAG CCTCTGCCTC ACGGG'ITCAA GGGATCGTTC TGCCTrAGCC TCcTGAGTAG CTGGGA117AT AGGCGCCTGC CACCACGCC~r GGCTAAT1T TTAGTAGAG ACGGGGMIC GCCATGTFIGG CCAGGCTGGT CTCGAACTCC TGACCTCAGG TGGTCCACCC GCCrrGGCCT CCCAAAGTGC TGGGA'ITACA GGTGTGAGCC ACCGCGCCCA GCCTATATGT AATAA=IrA ATGGGACCAT GAATIGAATA TrC7CTr GAATAGCAAT GACATAGCCC CrrCTATrGT ACATCTGCAA GCTGATACAG GGAATTC=~ TGTACCTGCG CTC TTCCCTcJ CCAGTCAGCT ATGGGGGTGA AAGTGTAGGG GTTCATCCAA GTCCTAAAAC TGGTAGCAAC TCCTAGGGCA GGGCTGATCT GGAAGGACAG ACCCTAGGGG AGGGTGGAAC T1rAAAAAGA AG~rCTGAAG GTAGTAAGAA GGAAATGAGG AGTAGTGTrA GGAAGGGGCT AACnl=T1C TTCflGC TCTT-TAT CTCACCTGCC CCTCCCCTG TATCC=~CT TCCI=rCC =1TCC=FT 'ITGTCCTCAC TTCATrCGTG CATCC ITCT GATFrCCTm ACC*TGCTAA AAGGAGAAGT TTGTTFGGGT ATCCTATATC AATGGCAGGA AGGT7GTIT ==C'~ACC 'IMATCCTAT AGATTCATAT TCTCAACACC AACCTCCTCC TTITCAGTr TCCTTCTTGC TTCTC TrGAC ACCACAGAGT 'FrGCAGCTrAG TACTTGGAGA GGAAAATTAA ACAGAGATAC TTGGACCAAG AGTAAGATGA AGAAAGTCTrA AACAACAGTA TAGTCrATAG TGGCAAGAGA GAGTATGGGG GCTGCTTAGC CAGGGTGGCT GTACATAAAG TATATC TTCA G1TT7ATATAA ACTGCTrATA GATGGAAATC AGAAAAMTA AA'TcCI-A ACTGTCCAAG AAAATTCTCA TI1TICAAA T'F7GGGACTG ATAAATGTGA CCAGTrCTGC 'TrACTGTCCA FIGCCTGAAA TGGAGCTIT7G AGGTGGACTG TATAAT~CT TCAATCTAA CTrCCAAATTC TGATCAGCGA CGCCCTCTGC TGrTCACTAT TAATATMAT TfACCAATCA AAGTAAAGTA TrGAAGTI= CCTGGCAGTrTTCACMrGT G=IAGTCC AMTAGGCTG CTATAACAAA ATCCCTrAAA CTGGGTAAGG GATTATAAAT ATrAGAAATr TATCT~CAC AG TrCTGGAA GC TGGGAAGC CCAATATCAA GGCACCAGTA GA7117GGTGT CTAACGAGGG TGTGCCGTCT GCTrCAAAAA TGGCCC=~G TFGCTGCATC CTCAC'ITAGT GCAAGGGGCA AGACAGCTCC CTrCAACCTC TI=ATAAGG GCACTTATGT CATTCATGAG GGCAGAGCCC TCATGACTTA ATCAC77CCC CAAAGGCCCC ACCTCT'TAAT AGTATCACAT TGGGTGTFTAG GTGTCTGGGA GGACACCAAT CTCAAGCCA TATCATCTCA CTTGGAAAAA AGTCAAAATA AAACCAGTAG AMr~AATrAA TATrACACTA T7ATAGAAG CATGTGATGT ATCATrCC1T GTA17AATT CCTGGGGT7G CCGTAACAAG TTACCACAAA CTAGGTGGCT TAAAACAATA GAA=Tr'T CTCTCACATT TCTAGAGGCA GAAGIFrCACA GTGTGTCAAT AGGGCCATGT TCTCTGGAAG GC'IMAGGGG AGAATATATT TCATATCMF CTC 17AGCF~r CTCGGTGTCA CTGc3CAATCC 7rAGCTrACT TrGGC=-CT GTGTCTTCAC ATCATCTI= TATAAGAACA CCAGTGATAG TGATTAAGGG CATACMTAC ITAATATGA CCTCATC=A ACTAA7FATG T=TCAATAA CCCTA=ICC AAATAAGGCC ACATrCTGAA GTATrGGGAG TrAGAAC~rA AAGCTITIG GGAGGGACAC AGT7CAACCC ATAACAACCC CTAAAATCGA TA'TFrATrCT CAAT7AAGTC 7FrGAAAT7GG nF7CAAAAAG AGAATATTCT ATrAGAG'Tr7 TTAATGTATA G7ThAACAT ATAGflTT AGCCCCCAAT ITM77Tr TTIr= T7ITMT TIFIGAGAC GGAGTCTCGC TCTGTCGCCC AGGCCGGACT GCGGACTrGCA GTGGCGCAAT CTCGGCTCAC TGCAAGCTCC GCTCCCGGG TTCACGCCAT TCCCCTGCCT CAGCC TCCCG AGTAGCTGGG ACTACAGGCG CCTGCCACCG CGCCCGGCTA A TITITGT ArTTAGTA GAGACGGGGT TrCACCTTGT TAGCCAGGAT GGTCTrCGATC TCCTGACCTC ATGATCCACC CGCCTrCGGCC TCCCAAAGTG CrGGGATTAC AGGCGTGAGC CACCGCGCCC GGCCTGCCCC CAAT7ATTTA G1TITCTAT AAACAGGGAA ATIATIGT GTGGCCCT7A GAACTAMTT AATICCACT CTAATrCCTA =FATGTFA TATAATGCT7 7rAGAAA'IM GTKF1TAflCA GAAAATAAAC ATATACTrATr GTATCTGTTG CCTACACTA GA=IFA77G CCTFGCTATAT FrAAA'lrA T7AGTATIT AATrG=rrA TTAAAGAAAG AATGTGCC TG TAATCTCAGC ACTITGAGA GGCCAAGGCA GAAGGATTGC 'ITGAGCCCAG GAG'I1rGAGA CCAGACTGAG CAACACAGGG AGACCCCCAT CTCTACAKAAA AATAAAAAAA 'ITCTCCAGGC CTCATGGCAC ATACCTGTAG TrcrAGrrrAC TrGGGAGACT GGGGTGGGAG GATGCAT7GA GCCCAGGAGA 7rGAGGCTGC AGTGAGCCAT GATCAGGCCA CTGTACTCCA GCTrGGACAA CAGAGTGAGA GCTTGTCTAG ATAGATAGAT AGATAGATAA TCTAAATAGA TA:ATAGACAG ATTATCTrAAA TAGATAATAG ACAGATTATC TAAATAGATA ATAGACAGAT TATCTAAATA GATAATAGAC AGATrATCTA AATAGATAAT AGACAGA FA TCTAAATAGA TAATAGACAG AT7ATCTATC TAAATAGATA ATAGAT7ATC TAAATAGATA ATAGATAGAT AGATTAGATA GATAGATAGA TAGATAGAGC FTGGACAACA GAGTGAGAGC CTGTCTAGAT AGATAGAAAC AAAGAAAGAA AGAAAGAATG GTGCTCATAT 7F1TAAAGCAT TGAAAAATGG TCTrCC=GC FTATATrACC CACACCT7CTr T17GT7GGCAT TAAGATGCAA ACrrrrvr AAACAGTTGA GTAAATCAAA GATGGGACTG TTAAGT7ATT TGTGTrA'IM ACCTGCT1TTI TGAAAATGTA AAAATAAAAC TCTAGGTMA ATTAGTAGTA TGCrA TI7AG TAATGAAGTA AAGCTAGAGG CTWCGAACAA ATCTWGTGTA AnhrCCTCT7 GAATGAGAGA GAAAATTTAA AGTAAGCAAA CAAATAAGT7 GTGTGTCACC ACTCAT'rCAG TCA'TrrAACA AGTAMrCCA GAGTACTTAT TCTGTGCCAG GAAATG'TGT AGGTGCCCTrC AACAAC'rAG AGTCTrAGCCT GAGACACAAG TAAGTAGGTA ATTAT7ATAG AATGGTATGA T=I]GGAGG ACTGGGTATr GGC~rGGCTCA TGGGAGTACA AGATAGGTAC CCAGTGATGA AGTCAGGAAA GG1T=TAT GGTGATATGA TGACGTCTAT GCTGATTATA AGGTCAGTGT AGAATAAACT F7GTGCTIT AAATh17GCAT AGCACTGTAT TAGAGAGTTC ATCTJ7CAAAA TAATCGAAAA GGCTrGAGTGT GGTGACCCAT GGCTGTAATC CCAGCACTJ GGGAGGCCGA GGTGGGCAGA TT1G=~GAGC TAGGAG7TCG WO 00/09525 PCT/US99/17712 EPI-109 149 AGACCAGGCT GGCCAACATG GTGAAACCCC GTCTCTACTA AAAATACAAA AATTAGCCAG GAGTGATGGT GCGCACCTGT AATGCCAGCT ACTTGGGAGG CTGAGGCAGG AGGATCACTT GAACCCAGGA GGTGGAGGTT GAAGTAAGCC GAGGTCATGC CACTGCACTC CAGCCTGGGC AACAGAGTGA GACTCCATCT CAAAAAAAAA AAAAATGATC AAAGAAAGGT GAATITTCAT CTACCCTATT TCTGCTGAGG AAAATGGACT ATTITCAAAT Ar1111AATA AGGGTCAAAA TGAGGGATC GCCACCATGG AAACCCTTTG CCTCAGGGCA TCCTIGGC TGGCACTGGT TGGATGTGTA ATCAGTGATA ATCCTGAGAG ATACAGCACA AATCTAAGCA ATCATGTGGA TGATTTCACC ACTTTTCGTG GCACAGAGCT CAGCTTCCTG GTTACCACTC ATCAACCCAC TAATTTGGTC CTACCCAGCA ATGGCTCAAT GCACAACTAT TGCCCACAGC AGACTAAAAT TACTTCAGCT TTCAAATACA TTAACACTGT GATATCTTGT ACTATTCA TCGTGGGAAT GGTGGGGAAT GCAACTCTGC TCAGGATCAT TTACCAGAAC AAATGTATGA GGAATGGCCC CAACGCGCTG ATAGCCAGTC TTGCCCTTGG AGACCTTATC TATGTGGTCA TTGATCTCCC TATCAATGTA TTAAGCTGC TGGCTGGGCG CTGGCCTT GATCACAATG ACTTTGGCGT ATITCTTGC AAGCTGTTCC CCFTI7GCA GAAGTCCTCG GTGGGGATCA CCGTCCTCAA CCTCTGCGCT CTTAGTGTTG ACAGGTACAG AGCAGTTGCC TCCTGGAGTC GTGTTCAGGG AATTGGGATT CCTGGTAA CTGCCATTGA AATrGCCTCC ATCTGGATCC TGTCCTTTAT CCTGGCCATT CCTGAAGCGA TTGGCTTCGT CATGGTACCC TTTGAATATA GGGGTGGACA GCATAAAACC TGTATGCTCA ATGCCACATC AAAATTCATG GAGTTCTACC AAGATGTAAA GGACTGGTGG CTCTTCGGGT TCTATTTCTG TATGCCCTrG GTGTGCACTG CGATCTTCTA CACCCTCATG ACTGGTGAGA TGTTGAACAG AAGGAATGGC AGCTTGAGAA TTGCCCTCAG TGAACATCTT AAGCAGCGTC GAGAAGTGGC AAAAACAGTr TTCTGCTTGG TTGTAATTTT TGCTCTTTGC TGGTTCCCTC TTCA1TTAAG CCGTATATTG AAGAAAACTG TGTATAACGA GATGGACAAG AACCGATGTG AATTACTrAG T7CTTACTG CTCATGGATT ACATCGGTAT TAACTTGGCA ACCATGAATT CATGTATAAA CCCCATAGCT CTGTATTG TGAGCAAGAA ATTTAAAAAT TGTTTCCAGT CATGCCTCTG CTGCTGCTGT TACCAGTCCA AAAGTCTGAT GACCTCGGTC CCCATGAACG GAACAAGCAT CCAGTGGAAG AACCACGATC AAAACAACCA CAACACAGAC CGGAGCAGCC ATAAGGACAG CATGAACTGA CCACCCTAG AAGCACTCCT -3' (FRAG. NO: 1738) (SEQ. ID NO: 1749) 5'-GCCACCATGG AAACCCTG CCTCAGGGCA TCCTITI1GGC TGGCACTGGT TGGATGTGTA ATCAGTGATA ATCCTGAGAG ATACAGCACA AATCTAAGCA ATCATGTGGA TGATTTCACC ACTTTTCGTG GCACAGAGCT CAGCTTCCTG GTTACCACTC ATCAACCCAC TAATTTGGTC CTACCCAGCA ATGGCTCAAT GCACAACTAT TGCCCACAGC AGACTAAAAT TACTTCAGCT TTCAAATACA TrAACACTGT GATATCTTGT ACTATITTCA TCGTGGGAAT GGTGGGGAAT GCAACTCTGC TCAGGATCAT TTACCAGAAC AAATGTATGA GGAATGGCCC CAACGCGCTG ATAGCCAGTC TTGCCCTTGG AGACCTTATC TATGTGGTCA TFGATCTCCC TATCAATGTA TTTAAGCTGC TGGCTGGGCG CTGGCCT1TT GATCACAATG ACTTGGCGT ATTTCTTTGC AAGCTGTTCC CCLIT1TGCA GAAGTCCTCG GTGGGGATCA CCGTCCTCAA CCTCTGCGCT CTTAGTGTTG ACAGGTACAG AGCAGTTGCC TCCTGGAGTC GTGTTCAGGG AATTGGGATT CCTTGGTAA CTGCCATTGA AATTGCCTCC ATCTGGATCC TGTCCTAT CCTGGCCATT CCTGAAGCGA TTGGCTTCGT CATGGTACCC TTTGAATATA GGGGTGGACA GCATAAAACC TGTATGCTCA ATGCCACATC AAAATTCATG GAGTTCTACC AAGATGTAAA GGACTGGTGG CTCTTCGGGT TCTATCTG TATGCCCTTG GTGTGCACTG CGATCTTCTA CACCCTCATG ACTGGTGAGA TGTTGAACAG AAGGAATGGC AGCTTGAGAA TTGCCCTCAG TGAACATCTT AAGCAGCGTC GAGAAGTGGC AAAAACAGTT TTCTGCTTGG TTGTAATT TGCTCTGC TGGTTCCCTC TTCATrTAAG CCGTATATTG AAGAAAACTG TGTATAACGA GATGGACAAG AACCGATGTG AATrACTTAG TTTCTTACTG CTCATGGATT ACATCGGTAT TAACTTGGCA ACCATGAATT CATGTATAAA CCCCATAGCT CTGTATTTTG TGAGCAAGAA ATAAAAAT TGTTTCCAGT CATGCCTCTG CTGCTGCTGT TACCAGTCCA AAAGTCTGAT GACCTCGGTC CCCATGAACG GAACAAGCAT CCAGTGGAAG AACCACGATC AAAACAACCA CAACACAGAC CGGAGCAGCC ATAAGGACAG CATGAACTGA CCACCCTTAG AAGCACTCCT-3' (FRAG. NO: _) (SEQ. ID NO: 2481) 5'-GATCAAAATT TTTACCTATT ATGCATrGA TATATAAATA AGTATATAAA TGCACACACA GACACAGCAA TGATGGTGAA CAGTCTTCAT ACAATTATAT GGATGAATCT CATAAAATGC TGAGTTAAAG AAATCAGACC AAAGAACATA TACTGAAAGA TTCTCTCTAT ATACAAAGTT CAAAAATAGG TGGACCAATT CATGGTGGTG TTAGAAATCA GAAGAGAGGC TACCTTGTG GGGAGGGGAC AGTTTAATGC CCAGAAGCGG TAAATAAGGA ATCCTCTGGG GAGTGGTAAT GATCTGGATG CTGGCTACAG GATGTGTTGG T7GTAAAAAT GCA ITITT ATATCTAGCT TTTTCCATGT GTATATTATA CTTCAAAGAA GTTCAGTTAA TAATTITCTCA TGTCACTGTA GAGTAGCTCA GTTAGCCCCA GCAAGCCTCT GGCTTAATCT TGTTTTACCT TAAGCCATCA GTCATTTACA AGTAGGAAAA TTCACAGGGA AAGTTAGAGT ATAAAATCCA GAATGAAGGT TTACTGGGTA AGAGTCTCTC CATTCCAA AGCCCGTTA =TCTTGATr CCAGTTCTTA AGAAGTCTCA GCATTGTGTC TITI1CATGT ATCTTACAAG AAGACAGCAT GTGCTTCTAA CACCTGATAC ATTGTATCTA CCAGCACTTG GTAAACAGAA AAGAACCACA 1T1TICTTGT AGGAGAAATT TGGTGCCTAT TTCCTACCAG GCACCAATAA GTGGGACCAA TAGGTGGGAT TAAAGATACA GTAGAAAGTA TTAAAACTT GCCAGGGGGC AATAGTCTGA AAATAAGTAA ATTGGTGCTA TAGAATGGAA GTrACAGGCT TCTTTU1111 TTCCCACAAG ATCTGCTCCT TGAGCCCCTA GAGAC1111C TGTCTGTTAC TGTITCTTCA TTCCTCATCT GCAGAGCCAG CCCTGAGAAG TGCAGACCAA AGCCAGGGAA GGCTCTGCAA AGATGTACAA ATGGAAGTCA CCTTAATAAC CTCTGACTGC TGCGCATAAT ACATTCACT CAAAAGAGGG GTrAAACAAT GGAACAGAAT ACAGAGGCCA GAAATAATGC TGAACACTGA CAACCATCTG ATCTTTGACA AAATCCACAA AAACAAGCAA TGGAGAAAGG ACTCCCTATT CCATAATGGT GCTGGGATAA CTGTCTAGCT ATATACAGAA GATTGAACCT GGGCCCCTTC CTTACATCAT ATACAAAAAA TAACTCAAGA TGGAGTAAAG ACTTAAATCT AAAACCAAAC ACTATAAAAA CCCTGGAAGA TAGCCTGGGA AATACCATTC TGGACATAGG ACCTGGCAAA GACTrCATGA CAAGACACCA AAAGCAATAG CAACAAAAAC CAAATTGACT AATGAAACTA ATGAAACTCT TTAGTTGTAC AACAGATAGT TTATCTGTAC AACAAAATAA ACTATCAACA GAGTAAACAA CCTACAGAAT GGAAAAATTT TTTGCAAACT ATGCATCTGA CAAAGGTCTA ATATCCAGAA TCTATAAGGA ATTFAAACAA ATTTACAAGC AAAAAAATGA CCTCATTAAA AAGTGGGCAA AGGACATGAA CAGATGCT TCAAAATAAG ACATTCACAC ATCCAACAAC CATATGAAAA GATGTTTAAC ATCACTAATC ATTAGAGGAA TACAAATCAA AAGCATAATA AGATACCATC TAATACCAGT AGGAATGACT ACTATTAAAA AGTCAGACAA TAACAGATGC TGGTGAAGGT TGTGGAGAAA AGGGAATGr TATGCACTGC TAGTGGGAAT GTAAACTAGT TCAGCCATTG TGGAAGAGAG TGTGGTGATT CCTCAAAGAA TGTAAAACCG AACTGCCT CAATCCAGCA ATCCCATTAT TGGATATACA CCAAAAGGAA TAGAAATTGT T'ACCGTAA AGGCGCATGC ATGCATATGT TCATTACAGC ACTATTTACG ATAGCAAAGA CATGGAATCG TCTAAATGCC CATCAGTGGT AGACTAGCTA AAAAAAAAAA AATGTGGTAC ATATACATCA CAGAATAGTA TGCAGCCATA AAAATGAACA AGATCATCAT GTCCTGCA GCAACATGGA TGTAGTTGGA GGCCATTATC CTAAGCAAAT TAATGCAGGA ACAGAAAGCC AAATACCACA TGTTCTCATT TATAAGTGAC AGCTAAATAT TGAGTACACA TGGACACAAA GAAGGGAACA ATAGACATGG GACCTACTTG AGAATAGAGG GTGGGAGGAG GGTGAGGATC AAAAAGTACC CATAGGACAC TGTGCTTATT ACCTGGGTGA TGAAATAATT TGCACACCAA ACCCCTGTGA CACACAA'TT ACCTATATAG AAAACCTGTG CATGTACCCC TGAACCTAAA AGTTAATGGT GGGGGGGTGG GGTTAAGCTA CTTTGTGGTA TAAATCTGAG CATTCATATT AAAATAAAAT ATACCTCA TTAGAGTAAT TAACATAT TAAGCAAAGA GCCAAGTACC WO 00/09525 PCTIUS99/1 7712 EPI- 109 150 TF7ACACACAT GATG'IMAAT CTCACAATGA TCYIAATCT CATAACAACC GTCCATrGTA TGTACATATG TGGAAATFGA GCCTTGGAGA GAT-rAAATGC ATGGGGCATG CCATTrGACT AGAAACTGGA AGCATCAGGA ITTFAAACTCA GTTCTGAATG GTI=GTAGG C1TGTI TCCACATrAT AGCATGGCCT GCCATGAAGA ACAGGTCCTr TCTGGTGTT GTCTcYG GM~AAGTGA AGCAAATAT7 TAT17AAATA TFrCAAGATAT GCTGTrAAAT 'F=ACTCAA AAATrGAGT ACAGTATGGA TCICTGAAG CCAAATAACT C=AIrCAAT GCITAG~rGA GAAATIIAT GGAGTAG ITC TCAATTITA TGT.AGTTCCA CTGCAAAGGT AAGTCTTATG GAAAGATTCA CTGTAA'Ir =F~CCTCAT TI7GGACATCA GCTITIC'IT 17CCTCAGAC CCGCTGAAAG ATAA'IT1TA AAATAAAAAC C=GTI=rA TATCAAGTGG GGACATITI TCCAAATGAA AACCGTGTAT TCAT'=ATA TGATAAAATC AATG~rATTA TT=AAAAT TTGAnITAA AAATCATTAA AAATAAA'IM TCAGATATTA CCTGAAATrC TACCATCCAG AGATAATAGT GCTrAAAGAT FrGATATATA GACACACACA CATATATACA TATATATCAT CCTAAA=TC TI1GTATAAA TGTATATAAA GTIlTAATA AAAACTAGGA GATTAATGCC CrrGAATGA AAATAAATAC AATGTGTATG CTIAACATC TrGCCT=AC 1TTTATAACAT TTATCACAGC AGTCATGAGA TAATGA'IMA CATGGTCATT GTrAGTAAGC TAATAGCTAA GTGCATGAAC TCTGGAGCTA GCCTCCCTGG ATITAATCC CAGATCTGTC ACTGACCAGC TGAGCAATAC TAGGTAAATr GCTMTGT-rC C17AGMFCT TCATCTGTAA AATAGAGATA AAAATAATAT CCACCTCATA GGATTGGTGT GAGCATTAAA TGAGCATACG TATGTAGGCC ACITAACAAC AATGCCI1CA CATACTGAAC ACAAATATAC GAGCTG F7GT CTrATrGGGC TCATG TTT CCTACCACTA AGCCGCATGC ATGCAAGGAC CATG'ITGG'rr TTGTITCCACA TTGCATCCCC AACCTGGTAT ACAGTGTGCA T7CAATAG F7 GflGACTATT ATTACTAGTG GCAITT1AACA AATATCTG17 AAATGAGTGA AGAAATACCC AMrACTGCA AGTGTGTCTA ATATrGATGG CATAATGGGG GAAACTrCAAA CTCTGGAGTC AAACAGGTrT7 TAAAACC17A TTCCCTCATC CTCAGTATr GACGIT1F TIGGCAGG TGTGTGTGTG GGACAACTTA 'FrGAACI=r CTGAATIT7CC AGCTTCGCAT ATATAAAATA GAGATAGTGA TrCATTCTrG CAATGTATGG A71TGAGACA ATTGTGTAAG M~ATCAATA AATAGTAGCT ATVITGTAT AAGTATI'ACA TATAATATCC AGGCCACTGC TTGCATAAC CCAAAAGGGG CACCATTCAT GCAGAATACA ACATAAATGG TGTCCCTGGA GCAGTGCAGT ATAGGAACCC TGAGGGGACC TACAGTATAC TFFTATAGflC ATAGAT7ACA AATTATCCCT 'FrATCAGAGT CTCTCAAGGT TGGATGTATT TGAGGTCCAT AAGAGCAATT TAGGATTAAC AGTAGCTGCA GAAACCATCT GCAGTGATAT TCTCAT=TA AATCCGCGGG AAAGAAGACA GCTATAAACT TGGGACCTGG GTITAAGCAT M~AAATGCC AAGTrCACCA TITCTAAAA CACAACAAAT ACCCAGTGAG AGAGGGAGAA GGGAAGTAAA TGCCTCTGAA TAAGCAAGT-r AATGTCAGTA GTTGTACTGT ATGCATATJG ATGAACAATA GAGGAACCAA TGTCCAATCA GATGAGCAGG ATATT17GGCA ATAACAAGTT GCC'=GAGG AAAAATGATr TrC=GGCAA GTrCT=ATC AGCAT7ACAA AGCTAAAAGC TACGCTIATC ATCACTrATA CTAGCATACC CTGT'TGTGCA AATGCTGTCT GTcYITGCAT CTGCTATTGT TGATGCCTGG TGCATGAATC AGGACTCCAG CCCACAAGTT TTCCCAGAAC TTCT=ATGG CCATCATCT TAAGTGTCTG GTGAACAGTC ATAGTT7GGT ACACAAAAGG GTCAACCTGG GGGATGGCTA GGGT'ITGACT CAGTCGFI'AC AITICAATAG AGCAGGAAGG GGAAATGGTG GCCTGTAACC TCAGGGAATT TTGCCAGT'TG GTCCACCCCA CTCTCTCTCT CCTGCTCTGA GGAAGTGGCA CAGCCTAGAA CAGCACCACA GGTGAGAGAA ATGCAAACCC TAACCAGAGA AGCAGACTCT TrGCCAGTAG TAATAGTTCA GGACCACCAC CAGCTI=AT TAAAA'TTr AATAACACI'C AAGTATrGGC AGAAAGAAAT AAT=TGGGT TAACTATAAC TAGAATATrG ACT=TCCTC TGTGGAAGAA TCAGCCAATC ACA'IT]GTI17 ACATCAGTTC CCCTGAAGAA GAAAAATACA CTGATGTTGC AGCAAGACAA AIFAAGCTA GATGTAAATA AC'rCCTA GCCTGTAATG CTAGGCTAAT TACATATrGG AACTATI= TCAGGGAAGA ATTGTGTAGG GMTCAGGGA AGAAUrCGA AGAAAATATA GAGCTGAAAT GATCTGCAG CTCACrGAAA CTGCAGGGTT TAGATCCACA CTGATACTCG 'FrCrATrATC ACTGTAATGA AGGCTGATGG AATAAGTAAA AATGTTTGT ATTAGTATGT TI=ACACTr A17TGCAAGG CATAAATAGG TTAGGTITG ATCTrFAATr AATTCTAACA TGTATrGTGC ACAAGCTGTG AGCAG=IIC AGGAGT-rAGG TATCTGGCCA TGACTGAMT 7TCAGGAGTr AATCATCTGG TAGAAGGGTC ATACACAATA GGAAGATGTG TGTGACAGGT TGTGATCAT-T ACTATAATCA CACAGAGAGC TGTAGAAMT TAGGCTGGCA GGGTGGCTCA CGCCTGTAAT CCCAGCACT TGGGAGGCCA AGGCAGGCGG ATCAAGAGGT CAGGAGATGG AGACCATCCT GGCTAACACG GTGAAACCCC GTCTGTACTA AAAATACAAA AAAAAAAAAA AGCCAGGCGT GGTGGTGGGC GCCTGTAGTC CCAGCTACM GGGAGGCTGA GGCAGGAGAA TGGCGTGAAC CCGGGAGGTG GAGCTGCAG TGAGCCGAGA TCGCATCACT GCAATCCAAC CTGGGCGACA GAGGGAGACT CAGTCTCAAA AAAAAAAAAA AAAAAAAGTC ATGTFAGATC CAGAGGGGTA GCAACTGGGG CTGGGCTGTC AGTCAACTCA GTCAAcTCAG TCAACTCTGC TCCCCCACAG GAGATGCCAG TGATGCA'IM TCATGGCCAA CATTGTCAGT CAGCATCATT GAATrACTCC TGAflATAGA GACACAGCTG CAAACGA'ITC CCCATrAAAT ATGATG'T7C TTGCAATc3TT TGGAAGGTAC TCC1TITAG TAAGGGAAAT CCCCTCTTCT GGC=GCTGA AAGTIT1TC 'TrCCATT= AAAAATCGTG AATrCC'IFI TGCAATATTG AGGTGGTTAT ATGGITM'CTC TTCTCTAATC TG17AATATG GTGATTT7AAT GGTTAGAAAT T7CTAATGT AAATI7CCACT CATATITGCAG AAATAAACCT AAACTGAGCA TGAGGCTATA 'FFFFFA2TT GCTTCTATAT 'FrGGTrGCTA TACAGTA11A TGTI17AAGAT TTGTTCACAT ATATTTGTGA ATGGGATTGG ACTAT1TC CTTCTrGCCG ATITATCT GGT=FFAAA TTAAGGATAT 'IMAGACTrA TGAAATA'1 GGCAAACAAT CCTTGGCAAG TAATTITTG GGGAATnTGT 'TGGCTAT7 TTGAGTATTA CCCAATATAT 'IMAATrAAG T7ATTC1TAA TGTITCTTA ATTAAAAAAA TTACCJ7ACTC TAGAGATATT C=rATGTAC TCCAGAT1T GTCTATr7AT ACCACTIC 71TI=CCTC GATGAGTGTC ATAGATGTTC ATCTATrIT 'VrATCTrCTr TGATC17CTC TrArCCrr '1CTATrAA CTCTGAAGT TrATTATI CTFIrTCCA CT7CCTrATG Gn7TATTCT7 TCAA'mIC TCTAACr TAAGTrGGGT G1T7AATIT TAGCTTGCTT TGCITITA GGATAAGCAT TAAAACTACA AA'IICCF GTTA FTT TGCTGCACCC CAAATrGrrG ATA'I=CTAT TGTCTAAMT CTATTCAATT AGAATACIT AAAG1TrCT7 TrGG'ITIT AAAAACTAAC TITIAAATT GACAAATAAA AA'ITGTGTAT AM~AT7GTG CACAGCATAT GG=1IGAAA TATATGTACA T7GTGGAATG GCTAAATrA GCTrATrAAT GTATGCATTA TCTCACATAC TrATCATI= TFTGTGGTGAG AGCTATGTGA C1TIGAACT TATGAGT7AT TrAAATA'1 TrAAATrATT AAGCATATTG GGATITAAG TAA'IMACCT T1TAT1AT7 AACTTATAAC AAGTAGAACA GTTAACCTGT ATGATTCTAC ATCATTGAAA T1TA FrGACA TITGCTTCAT AGTCTATTAT ATGGTCTACT =~GTTCATG TrACATCTGT AGTAGAATTG GCTAATAGTT GAGTAAAGTA CACATATGTC TATGAAATCA AGTGTAATCC AGAGAAAAAG AGAAA=~AC TGAATATATT GTTCTAGGTG CrATTATATG ITrGTCATGTr TAATCCTCAC CACAATTGTA TGAGGCAGCC ATAAflAATF7 CCACMTACA CATGAGGAGC CTGAGGGTTA AAAAAAAAGC TAGCTCTACT ATT7GTAAAG AATGAAGCAA AGATACAAAT GAAGGCCCAC ATATCCTATA ACTAGATAYI' TAAGCATIT7 AATTCAAGCr TrAAAACTGC TAAATAAAAT GTGCTCCAAT TrCTATATrG ACAGACATAC CTTCCTAATG AGCTGGGGTr CGAATIAGA AATCTFGAT GCTrCAGAGT CCACACTGAA ATGTGGAGGC ACATAGTGAG YrGGTCCCCA GCCI7CAGTC CACCCACCT CTC=rACTA AATCAC=T1 CACATACATG TATGAACACC CCAGCCTCCA AGTCCAAACC CTAAACAAAA TG1GGACACCC 7TGTGCATAC ACAGAGACAC AGCCCATCCT CAGGAAAACC TGGAAAAGTC CATACAAGTr CTGGAAGCAA GCTrGGGACG GM~CAGTAG TGTGGTCTAT AAGGGAGGCC TCAGAAGACA GG~IIcITA A I1CTGTGAA CTI7CTCCCAC AGTAGAAAGG GTGCTGGAGG AGGGTCAGAG TGAGGACTTC TAAAGCATGG GTCCTGAGTA GGGGCCACTC TrGCCCAAGT CTAAGAAGGG TACTAGAATA GCACACTACT ACTAGATACT AGAACCCAGA TACAAGCACA GGT=rCTGA AATTAATAAT AATAATAACT AT7ACCAT7A TTATACCAGT AGCTGTCATT TA'ITAGTGC TrATrATrrG CCAGTCACTG 'rTCTAAA'FrC TITACATGTA TrATACAACT GCCATATAAC TGCCATATGA GGGATGTACC CTCArrGTCA CCATM~ACC GATGAGAAA CTGGCATAAA ACG1TrAAGT AACTGTCCA AG'ITACAGAG C FrAGTGAAG CCACAATGTT GCTCAATITG CTCTCAAACT TCAAAGGGAT GGGAAGGACA CCTAAGTCAT AGAGTC'IA AGAATCAGAG CTAGAAGGAA TCITAGATGT TATCTAGTCA GCCTCCTCCC AT7ACAGTCC AAGAGAAGAT GGCCCTGAGT TACTTGTAGC TA1r=GCA WO 00/09525 PCT/LJS99/1 7712 EPI-] 09 151 TGTGAATTGC AAGTGAATAT ACATTCTACT GAAGATAAAA GATAMIAAA GATATCGCTG GATATAGGAA CAdTGGTIT AAATCrTIAG GCMrAAC r CTCAGAAC AAGAAATCCT =IIGGTIT AATCTATATG CACATCTGTA TTCTCAA TTATCGGGTA GTAAAATATA ACITCTIC TGTAATA T7 TIAAC'=A ATGAGTGTTC CTCATAATAG AAAAG'IMGG AAACCA ITGC TATGGGTATA TAC1TCTAA AGGGATAGTA A ITCTCTAG AATATrCAFTr TAATGCTCCA GAAGTAATTA GCACAATTGT GCAAGTCTGT GCATCATCAA CTATACA FrC TGCC'TG'ITrA CTCCAAATCC ACATGAAACT GATTATACAG TCAAAGGCGA GCCCAGTGGA GAGGCATIT TGGAGAC'r7C CTGGTACATT GAGACAGGGT CGGCCAGTCT GCGflAGGGT CT'GGTCAAA ACTGCATT7C TGAAACTAAA CTCAGAT7GC TITCTI=AA GGGGTCAGAA CTGATTCAAA TCTACATI= TAAAAGCCTI7 AGATGTGGGG CITCCTAT TCCCAGTCTC CGCTATTGGT CTFGTGAAT CCACAGGCAA TIGGCCACA TCCTrGACTC TCTCTATAT TAAGAATTAA ACAGCTAAGT TCATGCAGAG GAAATATAAC AAAGGAGGGA C'=CCTACA AGATCT=GA AAAATGGAAC A ITGCATAA GTCATA'I=A GCCAGAACTG TTG'ITITATA 1TICC'1C TGAATACTF GTrACACCTC CTCCCAGCCA ACCCCCCCCC TCCCTGACCC CAACrAGTCA GAGACCAAAG CCTCACAAT GGTITACACT TGAACMTCC TGGCCCCACC CTCATCATCA CGCCTGAATA ATTACA'ITCA CTGACTGGTC TCCCCTGCI CCGTIATcT CCACTCCTAA ACCCTCTGAC ACCTAATCT TCCCAGAATA CCATTGTGAT CCTGTTCCAC TCT7GCTCAA G=I~CCCAG AAACTrAGAGT ACAAA='~A TAAGC'=AG AGT-FGAAAGC CAC7CTATCT CTITICATC CCCAGGTCTC TGCCAAGGCA GTATAACCTG TCCAACATCT CTAACT7CAA TACC1TGTC TTAGATAC[A GACTCTCCTC CTGG=I~CTA ATFIAAACCTG ATCTAGGATC TAAT1TGCC TCTGAATI1CT GTrGCCC1T GCCAAGTGAT CTC'ITCCTCC TCTGAGCCc3C AGCATCTCTG AGCTTGCACA =TAGCATAG CCATAGCACA CACAGCCrrA GCT7GCAG7 CAGGGTGTTT ACC17CCCTC CCCITCCAGA TGCTGGATCC CCAGGGATAG GAACTCTGCC CTrATGTGTC CATAGCCCCT GGTAGTATGT crrGCAGTCG TACATITCA GCAAATGMT AATrGG FrAA TTGAAGACAA CTGTCCCATG CCTrAAGCCT CTCVITIGC TAAACATGCC TGTGTCC' I I GTCATrGAAC AACTATm'G ATCTKITIC T7CCTGACAT AGGGGTCAGT TCCGAGGATG CTGAAATCAA GAGACATAGC TTATTCTCTC AAAAT7GCH= TCAAGAGTGA =FTGTTGTG AATTGAGAAC TGGCTGCCTA C7TTGGACT ACCCACITCA GCAAGAGTGT TTGAAACCAA ATCrATrCTA AGTAA'TIT TATTCCCIT TCTrCTATGGC ATTAGACACA CAGCTCTIT AAACTACCTr TCGT1TATCTrA TTAAACAGAC ATrCAGTAAC TCTATAGiACA CTGTCTAGCT ATATGAACT7 AGACAAACTA ATATCTCTGA G=TCAGTF CTrAAAATr AAAATGAGGA CAATACCATC TATGGCCGGG GA ITAAATGC TATGAGGAAT GTAAACCAGA TGTCAGGTAC CATCTCTCTA AAATCCAGAT AAAATGAATr AAAAATACTG GCCGCAAACC CTCrCTAAGA GF17CTCAAAA TrCTCAGAGA G=~AAFI= CATGCTCACC ATAGCACCGA T=CTrCTA AATA II1GT TTCTACCAAA ATATITGTC CCAA'ITGC C7ITATGGC TA'TrTC1TCA TATCCAC T CCCAAACTAA AGAAGCAGCC CCTrCACCTT AAACTCCTCC rrCAAAGCAA CCTAAATACA GGTCTGGGTT TGTATrCCTA GTGGGATGTT ACAGAGGTTA GTGTGATGCA GAGGAGGAGT CATGCTGTTT AAATCCATAC TAGTCCCCAG AGGCCAGGCT GCTCTGCCA CCCCTACCCC TCCCGCCACA GAGCTCTTCA GCTrCTCACA 717CTAGTITC TrVI'CrCTCT ACTMCATTA C=C-rTCTCT TITMIrfITT =TCTCATGT GCTCACGGGA GCAGAGAAAA T-rAACTCCTC TAAGT=TCT TAACACAGAG TGC=TAA1T ACATAT7ACT AT-TG IGAG TTCCTGCCAA CACTACGTCT GTAGGGTCAC ACCTGCTATA T7AGAGGCTT ATCAAAAAAA GATAGCI=C TCCTAAAAAG GGATT17GGAT GCCTACTAAG ATAACTGGAT GCCAAGATAA G'ITAACCTA ACAAACI=A T7rrATrAT TAT7AT~rAT7 AT-FAGAGATA GGTACTTATr CTGTCACCCA GACTGCAGTG CAGGGATGCA ATAATAGCTC ACTGCAGCCT CAAAGTCCTG AGT7CATGCA ATCCTTCTGC T7CAGCTCCC TGAGTAGCTA GGACTACAGG CATATGCTAC TCTGCCCAGC TACTMIAAA AAAATAATrA GGGATGGGGT =TGT7GTAT TGCCCAGGCT CGTCTCAAAC TrCTGGTT7C AAGCAATCCT CCTGCCTIT ACUI'CCCTAA TrGT7GGAGT TACAGGCATG AGCCACAGCA CTCAACCAAG A'I=AAAAAC TITAAAAGA AATCACATI'A CT'rACTGTrA TCATCATTAT GGTTACTACC AGTGflAAAA CAA'TrGGTAT TGAAAACACC ACTACCAGAT CAAGCTTCAA ACCAAGATGT CAAGTAAATA T7ATTGTCAG ACCTCTGAGC CCAAGCCTGC AGGTATACAC CCAGATGGCC TGAAGCAAGT GAAGAATCAC AAAAGAACTG AAAATGGCCG GTrCCTGCCT TAACTGATGA CATrCCACCA TTGTGA7G TrCCTGCCCC ACCTGACTG AGGGATTAAC CTTGTGAAAT TCCTTCCCCT GGCTCAGAAG CrCCCCGACT GAGTAC=TG TGACCCCCAC CCCTGCCCAC AAGTGAAAAA CCCC='TGA CTGTAA'II= CCACTACCCA CCCAAATCCT ATAAAACAGC CTCACCCCTA TCTCCCTTCG CTGACTCTCT 'TTCAGACTC AACCrGCCTG CACCTAGGTG ATrCAAAAGC IT7ATTGCTC ACACAAAGCC TG'IMGGTGG TCTCTTCACA CAGACCATGT GACATITGGT GCCGTAACTC AGATCGGGGA ACCTCCcTG GGAGATCAGT CCCCTGTCAT CCTGCrCI I GCTCCATGAG AAAGATCCAC CTATGACCTC TGGTCCTCAG ACCAACCAGC CCAAGGAACA TCTCACCAAT InrAAA'FrGG GTAAGTGGCC TCT1ThACT CTCT7CTCCA GCCTCTCTCA CTATCCCTCA ACATCT=CT CCTECAATC 'TrGGCACCAC GC7FCAATCT CTCCCTTCCC TrFAAThrCAG TTC~CTrfl TT~cTGGTAG AGACAGAGGA AACGTGT7CT ATCTGTGAAC CCAAAACTCC AGCACTGGTC ATGGAC'ITGG AAAGACAGTC TITCC=TGAT GMIAATCAC TGCAGGGATG CCTGCCTGAT TArTCACCCA CATrrCAGAG CTGTCTGATC ACTGCAGGGA CGCCTGCCTG GATCCTrCAC CTrTAGTGGCA AGTACCACT TGCCTGGGTG GCAAGCACCA CCTCTCCTGG GGGGCAAGCA CCACCTCTCC TGGGGGGCAA GTACCCCCCA ACCCCMTCTC TCCATGTCTC CACCCTCTCT TCTCTGGGCT TGCCTCCT-rC ACTATGGGCC ACCTTrCCACC CTCCA FrCCT CCCITMCrC CCTTAGCCTG TGTTCTCAAG AACTrAAAAC CTCTTCAACT CACGTCTGAC CTAAAACCTA AATGCCTTAC MTCTCTGC AATACCGCTr GACCCCAATA CAAACTCAAC AATGG'ITCCA AATAGCCTGA AAACGGCACT TTCAAMTrCT CCATCCCACA AGATCTAAAT AATTCTTGTC GTAAAATGGA CAAATGGTCT GAGGTGCCTG ACATCTGGGC AT7CIT=AC ACGTCGGTCC CTCCCTAGTC TC7G77CCCA ATGCAACTCA TCCCAAATCC TCCTrCITC CCTCCTGCCT GTCCCCTCAG TCCCAACCCC AAGTGTCGCT GAGTVITCC AATCTTCCrT TrCTACTGAC CCATCTGACC TCTCCCCTcTr TCCCCAGACT GCTrCCTCCTrC AGGTCGCTCC CCGCCAGGCT GAATCAGGCT CCAA'rrCTTC CTCAGCGTCC GCTCCTCCAC CCTrATAATCC TCTATCACC TCCCCTCCTC ACACC7GGTC CAGC17ACAG MTCA TrCTG TGACTAGCCC TCCCCCACCT GCCCAACAAT TTCCr=~AA AGAGGTGGCT GGAGCTAAAG GCATAGTCAA GG'ITAATGCT CCTITTCTT TATCCAACCT CTCCCATCTC AGTrAGTAT7 TAGGCTflTT TTCATCAAAT ATGAATACCT AGCCCACTCC ATGGCTCATT TGGCAGCAAC TCCTAGACAT TrTACAGCCT TGGACCCAGA GGGGCCAGAA GGTCATC'IA 7rCTCAATAT GCAT1TATT ACCCAATCCA CrCCCAACAT TAGAAAAAGC TCCAAAAG Fr AGACTCCGGC CCTCAAACCC CACAACAGGA CTrAAF7AAC CTrGCCTrCA AAGCGTACAA TAATAGAGTA GAGGCAGCCA AGTAGCAACA TATTrCTGAG 7rGCAATrCC TTGCCTCCAC TGTGAGAGAA ACCCCAGCCA CATCTCCAGT ACACAAGAAC TTCAAAATGC CTAAGCCACA GTGGTCAAGC A'rTCCTACAG GACCTCCTCC ATCAGGATCT TGCTTCAAGT GCCAGAAATC TGGCCACTrGG GCCAAGGAAT GCCCTCAGCC TGGGATTCCT CCTAAGCCAT GTTCCATCTG TGTGGGACCC CACTGGAAAT CGGACTGTCC AACrTGCCCA GCACCCACTC CCAGAGCCCC TGGAACrCTG GCCCAAGGCT CTCTGACTGA CTCCTTCCCA GATCTrCTTG GCYrAGTGGC TGAAGACTGA TGCTGCCTGA TCGCCTCAGA AGCCTCCTrGG ACCATCACAG ATGCTITT1GG TAACrCTAC AGTGGAGGGT AAGTCCGTCC CCTTAAT CAATGCAGAG GCTACCCACT CCACATTACC 'FrCTC17CAA GGTCCTGTIT CC=~GTC'rr CATAAATGTTr GTGGGTAT7G ATGGCCAGGC TrCrAAACCC CTTAAAACTC CCCAACrCTG GTGCCGATr AAACAACAT7 CTF=ATACA =(:ICI I I IA GTrATCCCCA CCTGCCCAGT TCCCTTATrA GGC7GAGACA T1TAACCAA ATrATITGCT TCCCTGACTA 'FrCCTGGACT ACAGCCACAT CTrCATrGCTG CCCrrCrrCC CAACCCAAAA GTGGCAACTC C TGCCACT TCCTCTCATA TCCCCCTACC flAACCCACA GGTATGGGAC ACCTCACTC CCTCCCTGGC AACAAATCAC ACCCrCATFA CTATCCCATT AAAACCTAAT CACCCflTACC TGGGTCAACG CCAGTATCCC ATCCCACAAC AGGCTIAAA GGGATrAAAG CCTGflATCA CTGCCTGTr ACAACATGTC C'ITIAAAGC CTGTAAACTC TC=ACAAT TCCCCCATTf TACCTGTCCA AAAACTGGAC ATGCC117ACA GGTrAG FrCA GGATCTGTGC CTATCAACC AAAT-rGTCT-r GCCTATCCAC GCCATGGTGC CAAACCCATA TACT~rCCTA TCCTCAATAC WO 00/09525 PCT/US99/1 7712 EPI-109 152 CTCCCTCCAA AACCCCTCCA TA.ACCCTrAT TCTGT7CTGG ATCTCAAAAC ATGCTrTrT TACTAflCAT TFrGCACCCT7 CATCCCAGCC TCTCTrCAC T FrCACT[GGA CTGACCCTGA CACCCATCAG CCTCAGCAAC TTrACCTGGGC TGTACTGCCG CAAGGI7CA TGGACAGCCC CCATTACCTC AGTCAACCCA AA'TrCTrCT TCATCCA'ITA CCTATCCAGG CATAG ITCTT CATGAAAACA CACGTGCrCT CCCTGCTGAT CATGTCCAGC TAATCTCCCC AACCCCAGGA CTGGCAAA FT GAC1TACTC ACATGCCCCA AATCAGGACA CTAAAGTACC T=TGGTCTG GGTAGACACT T7CACTGGAT AGGTAGATGC C'=CCCACA GGGCCTAAGA AGGCCACCGT GGTCATTTC7 TCCCTTCTGT CAGACATAAT TCCrrGGM~ GGCCTrCCCA CCTCTATACA GTCTGATAAT GGACAAGCCT TrACTAGTCA AAGCACGCAA GCAGYT7CTC AGGCT=TGG TATTCAGTGA AACCTrCATA CCCCTrACCG TCCTCAATCC 'T7AGGAAAGG TAGAACTGAT TAATGGTCT7 TTAAAAACAC ACCTCACCAA GCTCAGCC CAACTrAAAA AGGACTGGAC AGTAC=ITA CCA=TGCCA TFCTCAGAAT TCGGGCCTGT CCTCGAAATG CTACAAGGTA CAGCCCAM1 AAGATrCTGT ATGGACGCTC CTTITATTA GGCCCCAGTC TCA FrCCAGA CACCAGCCCA A=~GAACTG TGCCCCAAAA ACTrGTCATC CCTACAATCT TCTGTCTAGT CATACTCCTA TI7CACCAflC TCAACTACTT GTAAATGCCC TGCCC TTT TACAGTGCTG A ITATACTT TTCCTCCAAA CCATCATAAC TGATATCTCC TGGTITACC TCAAACCGCC ACCCTTAAcIT CT7CTC17AAA GTGGATAGAA GATCTlCAGT GACAAGGTAC ACTCCAATAC M~CACCCTA ATAAAGCCCT AT'rrrAC T TrATAT7CA CT=TATrCT TGTrCCCA'Fr =TATGCCAC TCTCTACCTC TCCCCAGCTA TCTCCACCAC ACTFATCAATC TCACTCACTC TCTCCTAGCC A FFCTAATC C=='~AAC AAACAA'I7GC TGG='~ACA A7FTTCrTrr CCTCCAAAAT CACCGAGTCC TCAATIACT CACTGCTAAA AAAGGGGACT CTGCATATTT TITAAATGAAG AGTG'I1GTI1' T-rACCTAAAT CAATCTGGCC TGGTATATGA CAACATAAAA AAAACTCAAG GATAGAGCCA AAAACCTrGC CAACCAAGCA AGTAATrATG CTGAACCCCC TTGGGCACTC TAATTAGATG TCCTGGGTrC TCCCGA11TCT TAATCC1TA ATACCTG1T-r 'FrCTCC'ITCT CTTATGCAGA C=TGTGTCT TCCATIAGT T7CTrCAA FTC ATACAAAACC GTATCCAGGC CATCACCAAT CATTCTATAC GACAAATGTT 'ITAAGGGAGG AGACCACCCC TCATAT7GTC T7ATGCCCAA TICTGCCTC CAAAGAAAGA AGTAAAAATG AAAAGGCAGA AATGAAATCC ACAGGCAGAC AGCCTGATGC CACACCCTGG GCCTGGTGGT TAAGATCAAC CCCTGACCTA ATCAGTlATG 'FrATCTATAG AT7ACAGACA TTGTATGGAA AAGCACTGTG AAAATCCCTG TCTITG77CTG TFCCTCTAAT TACCAGTACA CGCAGCCCCT AGTCATGTAC CCCCTGCTTG CTCCCCCTGC TTGCTCAATC AGTCATGACC CTCTCACGCA GACCCCCTTA GAG TGTAAG CCCIAAGAG GAAAAGGAAT TGTI7CACTCG GAGAGCTCGG TTITGAGAC ATGAGTCF1G CCAATGCTCC CAGCTGAATA AAGCCCTCC Tr='~AACT CAGTGTCTGA GGGGrI=GT CTGTGTCTTG TCCTGCTACA GITCATCTA ACAACCCCAT AATATCACCC C=ACCACAA AATCTTCCT CAGCTTAATC TCTCCCACTC TAcIGTrCTCA CGCCACCCCT AATCCTGCTC GAAGCAGCCC TGAGAAACAT CGCCCGTrAT CTCTCCACAC CACCCCCAAA AATITCACT GCCCCAACAC 'I=ACCACTA 'IMCGTIA 'T1TCITAT TAATATAAGA AGATAGAAAT GTCAGGCCTC TGAGCCCAAG C~TGCACGTA TACATCCACA TGGCCTGAAG CAAGTGAAGA ATCACAAAAG AAGTGAAAAT GGCTGGTTCC TGCCrrAACT GATGATATTC CACCAflGTG A1T7GT7CCT GCGCCACCT~r GACTGAGGGA FTAACCT7GT GAAATTCCT7 CCCCTGGCTC AGAAGCTCCC CCACTGAGCA CC=GTGACC CCCACCCCTA CCCACAAGTG AAAAACCCCC 'IMGACTGTA A=ICCACT ACCCACCCAA ATCCTATAAA ACAGCCCCAC CCCATCTCCC TI7GCTGACT CTA'TI=GG ACTCAGCCCA CCTGCACCCA GGTGATTCAA AAG=TCA'Fr GCTCACACAA AGCCTG'IMG GTGGTCTCT7 CACACCGACA CGCGTGATAA TTA17ATATT ACITTAACT AAAACCC'1 CAGAGTCTCG CAGGGAAGGC TGTATATATC TCATAAAATG TrGGGGCCCA CTGGATCAGA CAAGGCCACA AAGGCCAAAG GGAAGTAAAG ATCTCAT7AT 'ITCTCCTAAT AA'T7CCCTG TCCTIGTCA TAAATGGTGG GTAGGCTG'F7 ATGGTGATGG CAGATITCT TrCCATAAAA TGTCCATAAT AGGACAIrG AACAGAAGGG AAAAATCAAA FrGCTGAAGT TGAAAGAGGG CAATGCAAAG AAC'IMGGAG AAAGAACTGT ACAGAGAAGT CAACrGGCAG ATGGGAGGAA GnITAAGGGG AAAAATATAG ATGTCTAAAG AATACA'IMA TCA'IICC ACAGTGCAAT TrGGACAAGA AGCCTCI=C TrGCT=~ CTATFCTCAT TAAATCATFA GAGCTCAAGC AATCCTTrG CCTCAGCIC CCGACTAGCT AGGACTACAG GTATGTGCTA CTATGCCCAG CTAATIT= AAAAATrAGA TITAAMTG GTGAACTA'IT TCTGTAGGAA ACTACAATAA TACAGCCCAG GCACAT7GAT CYI'GGGTGAA CAAATCAGAA GGAATGAATA A'ITCTGTGTT CCTGGGACTC TGACAA=TC ATGAACTTGG TACTCTGAGT AAAGCATAGG AGGAGTrATr TCATAAAATG TGGAGCACAA TCATGTGACA AAGATAATGG GATCCCCATT TCATAAATAA ATCTGAAG'rr CAGAGAGAGT AACAACTGGC CAGGGTCACA TCACGGAGAC AGAGGCAGGG TrCCCACTGA TGCCTCTGAC TCCCTGTCCC AGGCCC1TCC TCCTCCCGCA AGCAGAAGTG CAGGGGGCAG AGCTGACCCT GTGCAGTGAA AATCTGAGGG CTGAG'TCCT AT7GGAACAC AAGTGAAAGA CTCCTGGCT TCTAATCTCA GGATAAGGAC TCAGAGCTCC ATCTGTTCCA GCCTTAGGAT AAGAACCAGA ATCTTACACC ATGAAAGCAT GAAAGGTAAG ATTTGAGTGA GGAAAAAAAA AAAAAAAGTC TGTGIMCAG ATTCAGT7CA CAAAGCAG'IT TCATACTAA GGTACCATCA CAATAACCCT GTGGGGTAAG CAAGGCAAAT 'F[CArrTrG =F~ATGGGC ATAGGAAGTA AGTCTCAGGG AGG7FAAGAC CAAGG'IMCT GGAGAATIT ATAI'ATGAA TCTTGATMA TGGGA'FrACT ATI'ATGTAAT TCCTAAGATC ATATAGGAAT CCTAGAGCT GAATATAGAA CITATITF AAATCTATAT ACATCATAAT TACAAGGAGT AGTGTCCATT TGGGTTCCT7 GGCCCTGATG TGTrAGTGcIA ATAAACAMIT FGTCAGGGT TGCCATGTGT GTCTGTGCAC GTGTGCACTG TACAC~TCCA GGGGATGTAC CCTAAACCAC ATGAATGTGA 'TTrGCACATC CAAGAT'1TAC AGTGTACTAT AGGGAGAATC TITGCAACA GC1TFGCTA TAATACAGAA TCTGAGATGT ='TGAGAAA GAAAAGTGTA ATCATTACCA AAAAATTATr CTCATAATGT GTGCAAA'IM GTATGAAATC TATATTGGCC ATGGGACAAG GAGGTATTTC CAGCTAGCT7 CTGAAAGGGC TCTAT-rCTCT CATAAGAAT7 CAGCTGT7GA CAT7AGGTGA TATCTrGCCCA GGTCATCAGA TGCCATAGAG AAAGAGGGIT TGCTGAAACT TATATCAGCA GTGCAC7GTA TGCTC'=CT GAnI7A ITG AACATTCA17 TATrGAGTGT CAAGTAATGC ACTAGATACTr CCAGGGATCT GACACAAACT CTGCCCTGAA GGAGCATGTA ATCTCACrGG GGAGAAAACA AAACATATGA TAA'IMCAAA ATAACAAACT AGGCAAACTA GnrAACAC'rr AAAAAGCAGG ='~ATTCAA ATGCAAAATr GCATGTTACA GGGTAACCTT TCAGTAAGAA GCCAGGAAGA GGAGCTCATC ATGGGTTGGA TTAGTAAAGG ACrAGTTATA AAAGAAGTGG TGGGGTTGAG GGAGGCCTGA GATGAAATT AAAGAATATG TAGAATCTAG GTAAGTGGAT AAAAGGTCTG GGGGCAGGGG AAAGGAGAGC ATrrCATrGT GAATCAAGGA A'TrTCTCCAC CTGTMTAAC T=TCCATAT GACATCAAAG AGATGTCACT TGCAGCrAGC A'I7rCAGTGA TGTITCTrA CTAATAATAT CGTGATAAAA GAAACATrGA CTATAAGAAA TAGGAATGGG TCTCATAAAA GGAAACAGCA AAACCCCCAA ACTAAAAAAC AGCGCAGGCT A'TWCT7CT TCTCTrCC1 TGCTGGCAC TCATGAGATG CTAGGTGTGG AAGTCAGCCA ACTGAAAAAG AGAGGTGGCT GAAGAAGGTG GGGAGGCTGA AGCCAGTTAA ATAGGATGGT CCAATrFCACA GACGGCGAGG CTACAGTGCA AATAGGACTC 'IrrCAACMG AGCAGGACCC CATrA=TCA CTGGAGT17AG AAAGAAAGGA GAGCGTAGAC 'f=fGAACT 71TCTATAAGA GTGTACCTCC ACAGTATACA GAAGACGACG TGAAATTGA TC7GCAAGAA AACTGAGTCC ATATTCACAT ATGTATCAAA 'ITGCAC'rrC A'ITAGAAGT GTCTGTCATC AAGTACAGCA CTGAATrGAA ACTGAAAACA AGAGTCAAGA AAGAGCAAAG TCAGCCATCT TrATATTCCA CATGAATCCT TrCCCInrAT GGTCTTAT1T7 GTICTCCTC AGAAAAGACA AAAAGCTGAG CTGTATAAAC ACCTGTGGGC TGGGGGTFGA GGGATAAATG AGGGGCGAAA TGGAAGCTGA AGGAACTGITr GGTCAGGTAG AAATCTTrCCC AGATGCACTG AAGGAAACAC ACTrCATGTIT TGACGTAGGA GGTGCCACCA CACAAAACGT TrCATGGAAG GA'FrAAAGG ATCTCATGAT TITAGTAT7 CCAAGAATr TC1TCACCA AGGGCGA7TT AATATGGGTC A17CATACTG AAAGAAAAAC AAAAGATAAT AAGAGTTrAA AAAT7GCAAA ACT[rGGAGTG TrAGTAGTAA AGGTAAATAT TCATrAGAGA TGAGAAGAGG AGCAAGGAAA TG='~CAGC TGGAAATCTC AGACAAGAGG CCAGGC I IA GGAACCTCTG AAGATGAACA AATGTAAGCA AACCCTAGTA GCAGCACTC TCAGATI=C ATGTGCTrAC CACTCAGAGA TGGTGTTAAA ATGCAGACTC TGA F7CAGTA GGTCTGAGTG GAGCCTGAGA T7CTGCACCC CTAACAAGCT CTIAGTGAT GC'FATGCCA CTGGCGCACA GACCCCAC'PT GGAGAAATIT T7GTGGTGCA TACGGTC'= WO 00/09525 PCTIUS99/17712 EPI-109 153 GTCTCCAGAT CTAATGAGTC TGAAGGACAG TGTAGATTGA 11TTTAAAT TTATGTTTAT TTTAATTTAA TTTAAITTAA TTTATTTATT TATTTATTTT TGAGATGGAG TCTCACTCTG TTGCCCAGTC CGGAGTGCAG TGGCACGGAG GCAGCTCATG CAACCACGGC CTCCTGGGTT CAAGCGATTC TTCCGCCTCA ACTTCCTGAG TAGCTGGGAA TACAGGCACG TGCCAGCACA CCCAGCTAAT TTTTGTATTT TTAGTAGAGA TGGGGTTTCA CCACATTGGC CAAGCTAATC TCAAACTCCT GACCTCATGA TCCACCTGCC ACGGCCTCCG AAAGTGCTGG GATTACAGGC GTGAGCCACC GAGCCCAGCT GTAGATTGAT TTTGAGCAGT GGAAAGTCAA GGAATTAGAA GGCATGCTI'A AATGGAAAGT GAAATTGGAG AAAATTTAAA CTCATGAAAT AGTGGTGGTT ATAAACTCGT GATAAATTAT ATCCTGGGAT ATAAITAAT GAGATGGTAA CACATTTAGT TTAAAGAAAT AAGTGACACT TITI-TGTGT GACACAACTG TCTTATTCTT GGAAAGGACA AGGAGAGAAT GAAATATGGT ATGTCTTCAC AGCACCTTTC AAAGGGAGAA CCAGATTCTG AGGAGCTGGT CTCATGATGA ACTGTCAGGG TAAACCACAG TTCAGCAGCT GCAAATGTGC TTGCCAAAAT AGAGACAAAA AAATGTTTCT GAAAACAAAA TTCACATAT GCCCTCCTCT GAGGTrGGCA TCATATCTTC CTGTGTATCT TGGGTGTAGC TTCTATCCTG CCAGAATTTA GACAGTAGAA ACCAAATGAG GTGATAAACA GAGTCATTTT GCAGAAGAGT CAAAATAACC CAGCAAGAAA TGAAACCACA AATGCCCAAG GAGTCATTCA TTCACCATTC AAAAGCTAAT AGAAATGAAC ACAAACTACT ATGAAAATrC ACCCAAGAAC TTAAAAAAAA AAAAAAAGGC TCATGGTGTT TAGTGTGATA GTATTCATIT TACCTTTGAC TTGTrCTAAA AACACACCAT ACTTCTACCC CACCCTTCCT CAGTGCCGTC ACACAATGGT TTCAGTGTGA AAAAAAAAAC CACGTTACTG GAAAAGGAGG GTGCCTGGGA CTTGCCACTC TAAGCTGGTA GTCAAGGGTC TTGAGTrCTA AAAGCATACG CGTTAAGAGC ATGATTCCTG GATCCAAATG AGTATGGATC TCAGCATTGC CATTTATTGT GACCTCAGGC TATTTTATTT CTCTGTGCCT G7TTCTTTAT CAGTAATGAA GATGTTCATA GACCCTTCTC CCACAGACTT AAAGGCATAT TrCATGATTr AAGACATGTA AACCATTCAT AACAGTATAC AACATGGAAT TAATATTTGA TAAAGGTrTA TGATTATTGT AACTAACTCT GTCACTTGCT CAAGGCCTAT AGAAAACTTA CTTAATTAGT TCAACTACAA AAAGAGTrG AATGTGATAT CCACCAAGAT CATATTCAGA CCTAGAATrC TGTGATTCTT ATGAATTAAT ACAGCCTTGG TCAATAAATG AGAGCTGGGC AAATAATTCT TCTTTGCTAG GCCTTTCTAG ACCATCTGGT GAAGCATTCA AGACTTATGT TATTGGGGCC AGCCTTCCTT TCCAACTTCA ACTCCACAAC TCCTCAATAA GCCATGGGCT CAAGAAAGTT CTGCTCAGTG GCCCCTGAAA AATGCTTTCA TAGTCTCACT ACCATACCAC TGCTTACACA ATTTCCTTCC TACAGACTGC CTTCCTTTCC TGC11TTCTC CATATACCTA AATCCTATCT ATTCTTCATA AGCAACCTTC Tl'ATAACAT TTTCTATAAC CACCAAGCCA AATGACCTTT TCCTTCTTAA ATATAGCACC CATTGGCCAT TACCATGCTC TGCCTTGTAT TTTTCTGATT TI1TTCTTTC TATATTCCTG TCTTAACTCC CCAGCTAGGT AATAATTTTC CTGAAATCAG GGACCAGGCT GACTCCTCTT GCTGTCTCAA GAAAGCTTAG CAGTrTCCAA CACAAAAATG TTCAATAAAC AACTATTAAT TGACTGATTA TAAAAAATCA GTGAACCATT AAACTTAATA TAGCAATTTG CTTAGCATGG TAATTAGCTT TTTGCTAATA TTCTTCCAGC CAGTCTCTCC TCCTGTGCCT CAAGGACATC TTAAAAAAAA AAAATCTAGT TGATCTGCTT CCATCTAGTG GCAATTAAAA CAGGTGGTTC CGGTAGCCAG AAAACAGCTC TGGGTAGATT GTGCCAGAAA ATACTTTCAC TCAGTAGGTG CGAGTGAA AGAAATCTTC ACATCTGTGG GTTTCCTGCC ACAGACATAG GGAGACCAGC CCAGAGAAAG AAGCCTTTCC TCACTAGACT CCATTTGCAC TAGTAAAGAG AAGACAGAGT AATTAAAAAG AATAAAAAGA ACCTCCACTG ATCGTACATC CTCATCCAGT TACCCCTGCC CCACTTCTCC TTCACAGCCA AACATTTTAA AAGAGATGAC TGCTTGTTCT GTCTCTACTT TCTCATCCTC AGTAATGCTC AATGCTTGGC CGTCTGACCT CTGTCTTGAT GTCTGCACTG CAAATAGTCT CCCCACTGAC ACCCTTGTTG CATCCAGGGG ATACTrACTG GTTCrCTTGG CAATGTTTGA AACCGTrCCC CTTTCTTTGT TTCCTTGGCA TTCATTACCC CACACTCTTT CTCCTCTTCC TTCTCCCTGC CTGGCAACAT CT1TTCATTT CTCTTTCCCT TAGGTGACTT ATTAGATAAT GATGTTCCTC TGGCTCCCAT ACTCTCTCCC AGGTCCTCTT CCATTCTTAA AGCACTCACA CCCTCCCTGG ATGATAGTAC CCACTCCTGA GATGGCAGTT ACCTCCTGAA ATGTGAGGGA CCCAAATCCA CTTCTCCTGC CATAGCCTCT GTGCTTTGGA TAGGTCCAAT GAGCCACAGT GAATGATGTG CATACACCCA AAGCTCAGTA CAAAACTGAA CCCATGATCT TTACCTCCAA AACCTCTCAT TCTITTATGT TCCCTTCTCA GAAGTAAACA GGACTACCAT CCGCCAGIT CCAGGTGAGA AAGATGATAA TTTGATrCTT CTCTCTCACT TrTAGCCAAT TAACAGACAC ATTCAGTrAA TATCACCTCC TCTTATTTCA TGAACCCATT CTTACTACTA GTTCCCTAGA CAGGCGCCAT CGGTTTTAAT CTAATAACTG CAAATGCCTC CAAAACAAGT CTCTTTGAAT CCAGGCTCAC CTGTCTCCCA CACTTGCCAT ACTGCTCTGC AGGGTGACCT TATAAGATGC CAGAGGTAAG GCTACTCACT GTMTAAACCC CTTTAGTGAT ATCCCAAAAG ACCTCAAGAT AAAGCCCATA TCACATGGCT TATACATTAG TTTATGATCT GGCTTCTGGT GCCTCATTTT TCCCCACTTT TTCCTTTGCA TTCTAAGCAA TGGCCCATAC TAAGTGTG ATTGGTAGGA TGGTTGCCCA AACCAGCATC CAATCCCTTC AGAAATCATC TCACTTCATT TCTAGCATTT TAAAGGAAGC TCAGTTGTCC AGCTGGGTAC TGAATATGTC ACCAAAGTCC TCCTITCATA GTTTATTTTA CTTAAACTCT CCTTCCTAAA ATTCCAGAGC AAGTCACTAA ACCCTAGATA CTGAGAAATA 1TTrCCATC TTCATTTCTG CCAGGTGGGC CATCAACTTT CACATGTCTG CATCTCCTCC CACTGTGCTA TTTCTCCAGT AGAAGAAATT TGAGCTTCAA GACCAAACTG AAAAATACTT GCCTCCTTGG GGAAGCTGTA GGTAGAATTC ATGCTCCCTA TCTTTCCCAC ATTCTGAAG GACAATGCCT GTTAGAGCAA TTGAATGCAA ATAGTCAATT GAATAAGCAT TTATTCATTT CTCAATAAGT GCTTGTTCAA TTGAATATTT CTTAAATAAT ATATTTAAGA ACAAGAAGAA CACACCACAA TGTiTTAAC CCTCAGAAAA AATTCTGAGG TAATCAGAAA AATCTCCCTT TACATAAACT GCCCTITICT AATAGGGATT ACTTGTTCGT TCATTCATTC ATTCAGCTCC ACTAGCACCA AAAAGCACAG CTCTGAAAGG AAGCTAGTAG ATTTATCACC TTATCTGGTC AT'fGGATGA GGACCCCAGG TAAATAAACT ACTATGGGGT TAATGTGTCT AGCTAGAGCA GGAAGTAACT TAAGGAAGTA GAGAATGAAT CAGCAGATGT GGAAACTCCT CGCCACTAAT AAAACTTACC TTCTCTTGGA TTTCTTGCCT GAAAATAGAA AATAGAGAAA AGGCATTAGC AAAAATTAGA CAATTAAAG 1TT11-CAAGT AAGGGAGAAG GAAGACTCCC ACTCTCAAAA CTGTCITITIG AAGTATATTA GGTATTTGTT AGGTGGACCC TATCTGTGTC AAAGGAGATT TGAGGAACTG GCTTAATAAA CAGTGGTAGA CACTAATACA GAACAGACAT GTTGATGCAG ATGCCTCCTG AGGTTCCATT CCATTCTCCG TGCTACTCAA GAAGACAGAA 25441 TTGCTAAATT GCCTGGTGGC AAGACCCAAT ATGTCCATTC AAGTGTTTAT CCCTTCCCAA TCTGCCATCT CATCCTACCT GCAGATTCTT CCCTTGAGGG ACAGCTGCTA ATACTGTAAA ACTATGTGCC ATTACAGCTC ACAGCATCAT CTCTATGAGA ATCCACAAGA GAATTTCACT TTGGTCTTGT TGGTAGGAAT TGTGCAGCCT CATCTGAGTA ACTAATGTGT TITTATCTTA CAAACACAAG GAATATCACA TGGTTCTCCT TTGACTGGCT GTAAGGAAAC TCAGAGCTAG ATCTGAGACC CTCTCCTACC AAGTATATAA AACT1TGTGA CATACATITT TGTGCCATAA CTTCAACCTT GGTTCCAAAT GA'ITITGTA CCCTAAGTTT AAATTGGCT TrCITITT mTITrGTA CTCAATAAAA CATCAAGCTC ATTTATTATT GCGAAGAGCG AAACAACAAA GCTTCCACAG CGTGGAAGGG GACCCGAGTG GGTrGCCCAA ATTGGCTTCT TTTTCTTACT TTTTAATTAA TITTAATTTG CTATACTGAA CACATTTTGT ACTGTTCTCA CATrTT GAAAAAAGCA GAATATAAAT AAGTAGATAA CTTAAAAAAA ACTCTTTGAG CAGAAAGAAT CATTTGGGAG GCAATATATT TCAGTGGCTG TAAAGTGGCA TTCTAGAATC ATCCTACCCA GGTGAAAGCC CTATTTTGCC ACCTGTAGTG TAGTGTGTAT TTGAACAGCT ACTTTUIIIT I CTAAACTACA ATTTCTTCAT CTGTFAAAGA GGCATAATAA TrGTATCATC CTCATTGGGT TGATAAAATA AAATATTTCC AAGTATTTAG TTCAGGTCCT AGCACGTAGA CAGTGTTGCA TTACTGTTTT AATCCTTTAA AGTATTAAAG ACTACTATT GAAATCFTrT CTTCTAAAAT TCAGCCTGCT GATGACCAAG TGCACTTGAG CAGGGGGAAT CAAATCTGAA TTAATCAG ATTCTGG1A GCI TCACATA AATA1T11TT TJAGGGATGA TGAACCTAAC AGCAATAGAT GAGTAAGAAT CTGTTCCTAC TGAGAGAGTT TCATTTTGAA GAAAAAGGAA CTAAGGGGGC ATGTGTTCAG 'TTCATGCCC TGGTCTAACC CTGTGTGTrG GTTCTGGTGG GAAATTCTTC CAACCGAGGA AAAAACCAGT TCACAAATCT GAAGACCAGT GATTTTAGAA GATGTATCTG GACTGGAGTC TAATCTCTGA CTCTGGGTCC TGCTGATATG GTATTTTTGA GA'TrTGGCCT AAAACATCAT TGCCCTGGTT TCCTTATTTA CCAAACAGGG CCAATGGTAG TGACTAATCA GAAAATGATA ATGCCTGGTG CACAAAATGT GTCTAGATGA WO 00/09525 PCT[US99/1 7712 EPI-109 154 GCCCATGCAC AAGGACACAT GMIrGGAA CTGTTC=TA FrCC'=CCT AAAAGAAAGG AGGGAAAGTC TCCATACTAA GACTACTAGG GCAGGGGACA AAGTGCTAGA GTCAGAAGAT TCATCTGAGG ACAGAAGAAT AGGGGTGAAG GCTCTAGTCA CTTCAT7GGC TACCATGCTC TAAATAGTTA CCTGTGCCCT TITCTAACT ATTAGAACCC AAAAAGCCTA TAAATTCTCT CTCTCTCTCT CTCTCTCTCT GTGTATATAT ATACATATAC ACACACACAT AGACACACAC ACACACCTAA ACACACACAT AGAGA'IMAT GAC7n=AC TMTATC=T GTAAATGCCA TrAACTATAT ITIGTCT1AG ATrTAGCCTG GGAATGTAGC CATTATITCT ACCATrGCCT CCATAGGAAA AATACrCTC ATGTI=AAA GGACCAACCT ACAACTAAAA T=rrGGAAA GCAGAATCAT TTGTAAGTTG GTGAAAATGG AAGATGTTGT =~ATAAATG AAGACTTr TfTTr =F~GAGACA GGGCCTCACT CTGTrGTGGA GTGCAGTGGT GCTGTCATGG CTrACTGCAG CCTrGACCTC CTGGGTTCAA GTGATCCTCC CACCTCAGTC TCCTGGGTAG CTGGGACTAC ATGTGCATGC TACCATGCCT GACTAATMT TrGTArnT GTAGAGATGT GGMTCGCCA TGTrGCCCAG GCTGGT=TG AACTCGTGGG CTCAAGTAAT CCTCCTGCCT CAGCCTCCAA AAGTGCTGGG ATTAGAGGTG ACAGCCAAGG TGCCTGGCCC ACAGATGAAG ACTA'I=AAT GT7ATCTTAA AGATACCCTA AGCT7CCTAC CAAGCCAGTG ATCTITGGG GCFG IT TC1TGTTGG CATAACTGTA ACTAGCCTAA CTGCCCGTrA TCTGTrCCT GMrrGCCCCA CACTGA ITCC CACAGCAGTT 'FrCAAGTTAT CGGnF7GAGA TCTrGTACAG AAATGACTCC AAGGTAAAAA ATTTAAAAAC AACCCCTCTA AT~iTITAC C=TG=TAT AAAACAGCCT TAGCCAGCTA ACCCCTCACT ACATGCAAAT GAG7TTTGA F7 CTATTCT=T GATrCTACAA ACAC17ATTA AAAGATI=A GAAITCGGAA ATAAATAGCT TCCTATI7AA GGTGACTT7AC AGCCCCAAAG TCCTrAAAAT TA ITAGACA ATAGCCACCT TATCCCAGGG GGCAGTGTGT AATAACCCAC CCTGTrCTCT ATCCGTCAGT TCTGCCATCA TCGCCCAAGG TAGGAAGAAA GACAGGACAA CCGGGGTCAA GA 1TGAAGT CTCAATGGAA AGAATAATCA GTGG ITGGAG AAAAC1rGTCA TrCCT GCCTTAATGC AGTACrrGAT ACTATACITr AGTACTGTAT AGTACTTAGT ACTGTATAAT ACTATAAGAT AGTGAGA17C AATCAGCACA GAAT=CTAA TAGCAAGGGC AGAGACA FI TAACTGCTCA GTGCTCTCAG GT7ATACATA GCTAATGAAG TTCTTGCATA TCAACAATCC CCACCCCCCT CACACA='T GTC7GG A'FrGGTrAGA AAA=TACCT AGCGCCCACT ATTCTCAAAT rrAAATGAAA GATAAGATCA GAGTGGCACG CAATTAGGGA CTGATAAATA ATA7I1TGT AATrGCCAGT GTAAATGGAC AGGGGGCAAC =TTACATAC CATATrCAGT GAACAGAATA CGTACTAACT AA'ITGATGG AAGGAAAATT AAAATGACAA TCAACTGAGC CCACAGAAAG GCAACACAGA GCAGTTGG'IT AGCAAT7GTr TCGAGATCAT CCCTGAACTr GAAACAGGTA TATC1TIT= 71FF-rrrr TTGAGACAGA GTCTCACTCT GTCACCAGGC TGGAGTGCAA TGGTGCGGTC TCAGCTCACT GCAACCTCCG CCTCCCGGGT TCAAGTGA'FT =TCTGTCTC AGCCTCCCGA GTAGCTGGGA TTACAGGTGC CCGCCACCAC GCCTGGCTAA TITIGTATI' 717AGTAGAG ACAGGG'ITC ACCATGrI'GG CCAGGCTGGT CTTGAACTGC TGAGCTCATG ATCCGCCCGC CTCGGCCTCC CAAAGTGCTG GGATTACAGG CATGAGCCAC CACACCTGGC CAAAACAGGT ATATCT[AAA AGCTGCCCAA TGTCCATGAA TGTTACAGCC 77GAATGGIT =TCCAGGTG AGTIGGCCA AATGTGGCAC CATACACCCA AGGCCTGCTG CAGGCTAGTG GGTJ7GCTCAC ACMPAAAGC TGAGACACAC TCATGCCTrA AGGTAAAGGG AGTGATAATC TGGGCAGCAG ATGTrAACT'T CTCAAGGCAG TCCTCCTTCT CTTICCTCT CCAGTGACGG ATGG FrGGAA AGCATATATG GTGCA1GG TTAGAGCTGT GGCCTGGTG AATAGATACT TGGGAGAATA CATGGGAATr TCTCCCAGGG 'F7AATGCAAT GCCCATGTGT TGGGAACCAG GTGACT=TG AAGAGGTCAG GTATTGGGA GCAGTGC=T GAAACCTTAG TGGACATTAG ACCCACTICC TAGTGGAA17 GTAGCAITrGA AATCCAAGGC ATGTAGGCTC TTAGAGGACA GAGATAGTGT GTCATT=IT CAGAATFAAT TAAGAGCAGG CCAGGCGTGG TGGCTCACAC CTGTAATCCA AGCCC1TGG GAGGCCAAGG CAGGCAGATC ACGAGGTCAG GAGATCGAGA CCACTCTGGC TAACACAGTG AAACCCCGTG TCTACTAAAA ATACAAAAAA TrAGCTGGGC ATGGTGGCAC GCTCCTGTAG TCCCAGCTAC FITGGGAGGCT GAGGTGGGAG AATAGCTrGA ACCCAGAAGG CGGAGGT7GC AGTGAGCTGA AAflGCACCA CTGCACTCTA GCCTGGTGAC AGAGTGAGGC TCTGTCTCAA AAAAAAAAAA GTATTAAAGA ATTACATAAG AGCAAAGAAC CATTAGAATA TCTCAC=AG 7FrG'TATCAG CCTAGCAAGC TGCC'T7GAAG GTAATAGACA T-TTAAAAG T7ATCAGAT GAAAAGCGAA AATCAGCCAA CCTGTITAA TGAAGGTGTG TCCTGGGCTG AM~ACATGT CTCCAGGGAC TGATGGCTCT AGAATGTAAA GCTTGGCATC CTGCrTGTGT TGAATCTATC ACAnITAATT TCCTGTGGGT TITCTFITI= =~CTI=C AC'TIAAAGT TGTG7~TT TCATGTGAAG TFAAACTCAC ATACCIT=F TFAATCTCCT TGCCAGCCAA ATGATAAATG CCAACCCAGA GAATGCAGTA ACCATGACTG CCACTGGAAT GAAGAGGGGG TTATAATCAC CCTCCTFAAT CATrGAGAAA CTI=GTCCA A FFCTGAAAG AGAAATCAGT AAGGCACATA GCATGAGACC ACCAGCATTA TrC=AGT CTATCTCATG ATAT7GACT 1TI=CCTCC 'FTACATCTCC CAGTAGTAGC CCA'ITGATG CCA T7GACA GATGAGGAAA CTGGCATGGG AAGGCCCCTG ATGAGTCTAC AGCATAGGCA AAGACTGGAC CAGCCTTGCT AGT~rAATGC CTACAGAATC TCAATGCCCA GAInrGTGGT TCATAGAGTT CCTGAAAATG CACCTAAAAA TG FfGGCAAG AATGGTCATC GTrGTATrA GCTCCATGGA CIGTTCAAT GACTGGAACT CTGAAACACA GAGAAGAGCT AAAAGCCTAA TACAA=TCA GGAAAAATAA AAGCCAATGA TCTGAACTGG ATAATrCACC AGTCAAAGGA AATCATrAAT GCT=IACT TAAAGCAGTr GTGCAAAAAT AAGCA=TGA TITIACATG CCAAGGACCT GCACTAA=~ C3TCCAATG CAGTAGT7AC CAcrrCCCTC TACT'TCC'ITC ACGAATAAGT AAAAGGGCAT GTTAGAGAT ACTCTrGTAA GTGTAAACTA AGTrCA'ITG GGAGCCTCTA TITGAAAATA CTGGTATAAA AAAAAATCTG TCTCCTGATA CTAACA=TG AAGGAATCTA C1TrTACA TATrGGCAGA GGGTCTGATT cTrATC=TAG TTCTTCCCAT TAC1TGATG AACCT1TTCA AGGTGAn7TG ATCCCCACAC CCAAATATAT GATTGAGAGA AGGCTCAAGT TCCCAGGAGC TCCAGACAGA Ac3GTACCTGT TGGCTTGATG AAGATGAGGA GGAAATGAAC ACTAGCTAGG C=TAAAGGG AAATGTCTCT GATAGGCCTA ATACACAGTC CTCTGCTAAA GGCCTCCCTG CCTCTCTCTG CTCATCCACT CTACTCCCTG GCCCTGGGCA CGCAGCACAC AGAGATCAGC ATITCTGACA GMTCTGTAG ATCCTACCAT F7AAAGACTr TrGTCATCCA TGCAGATAGT C7CAGGAGCA GACACAGGTA GCTATrCTI CACATGCTAG CT17AACATGC ATI7rGC1A GCACCTA'ITG CCAGGCACTG TGTCAG1GTGG AGGGTATACA AAGATGAACA AGACATGATr CITCTCATAT ACAGATAGAT 'TTrGGAGGCA TTAGCTrAGT GATGAT7CAG GAGTATCCAT TAMTGGGGA AGTAGGTGGT CA1TAGTGAC CTITACAGG CA'ITCAATG GGCTAACAGA GATGTrAGAT TGTAGTGGAA TAGAAGAATG GGTAAAAAGT AAATCAGTGA GTTCAGA'IM TAGGAGTTAA GATGGCAAGA GGTGAGAACA AAAAAAGGAA ATGAT7GTCA TTAAAGGAGG AGGAAAGACC AGCCAAAGAT ITACAGTGA GTrTAAGCATA CAAATIATT TCTAGGCCAC ATATFCTrAG CAAAACAACA TGTAAATGTT TATGTATGTC M~CCTCATA TCTGCTCATC CATCAGCTCC ATCGTTAAGA T17CAGTIT CCAGGACAAA CTACTCACT TrGACATATr GGACTAGGAT TITGACCAGAT TCCAGATGAT TCACAAATGG =IT7=rr CCCAATTAAC TCAGTTCCTr CTGAGCAGAT GAAGGTACAT GCAGAGGTAA AGCTGAAGCT GGCCAGGGGA TGGCTACAGT TCATGATCCC CAAATCTGGT GCTGATAGAG GCTCACACTG AATCAC=CA ATGAAAAAGA AAAAAAAAAA AAAGACAAAA CAGTA=TCT GAGTAGAGAC CCTCCCTJGA GCAAAGGATT TI7AGCCAAA GCTGCCTGAC TACA'FrAC' GTGATATTGC FrCCAGGC'I TA=1TCTG AGAATGATGG TGGGTGGTGA ATGAGAGATG AAGGCAAGGA AGCATTGAAA GCTGTGGGGA GAGGAGTAGC TACTCCAGGC TGCTGCCCTA GCTAAGGTGA CCCrCCCcr CTGCTGGAAG TACCATGCCA TATGGCCTCT GCATCAAGGG CTCTFATGGG ATAT7CTCAG AGAATCTCTG CCGTICATC TGTrCTGATA TCTACCCAAG CATITGAAA AACATCCCAA 'FrCACTGAAG CAAGTCCAAC FrCCGTAAAT TCCAGTAGGT GGGTTGACAG TITATAATT TCAATAAGGG ATITGATAG CACITCTAAG AA ITAAACTA CTTAAACTAA TGCATCAGGA GCATACTTGT AGAAAAG'FrA ACCAAAACTr CGTAAGTTCA GATGACATTG GITICTCCC ATATGGAGAT AAGGTrGGCA GTrAAAAATG AAAAAAAAAA AAAAACCTAC C=A'I=CAA ACTrGAAAAG ATCAAGAGAT TGTG TT=G T'IT=CAGT GTrATrCTCC TAAAAG=FA TGCATGAGGA AAAGTAAAAG TGATI=AAG AATAAGCCAA ATAAAACAAC CAAGAAAGAC CTCCACTACC CTGGGAAGGA AACTGGTTGG TArrAAGTAG GACACCACAT AAAACAGGTG TTAT7GAGAG GAGAAGAACC AAAATGTAAC TGAGGTI7CAA CAAGACATrA 'IMATGCAAT GGCAATGAGA AAAATAAAAA ACACAGTATA WO 00/09525 PCT/US99/17712 EPI-109 155 ACCATGCTGT ATTGCTATAA GTCATGTrAC ACACTGGGAG ATGGCTTCAG GGGTATTGG T11AC= T7GTITGGGA GGTITCAA AAAAATI'AG TrAGAATAAG TCCTTGAGA AACATCACAG TAGGTTAAAC AAAGTTAGGT TAAATTAGGC TCCTAAGTT GACTTCTCAG CAAACTTCTA CTGAATGTTC TGACTGTAAG CCCAGGATTG CATGACAAAA CCTCTAGTCT GAAGTTACTC ACCTTGACAG GTTGGTTCTG GAGATGACCA GTTTCCAAAT GGTCCACAGG TGGTTTCTTC AATCCCAGTT AAGTTTGTTC CTTCAGAGCA GCTGAAGGCA CACTGTGAGC TGAAGCTGAA GTTCCCAAA GGGTGAGTAC AGTCCATGGT ACCCAGCTCT GGGGCCTCCA AAGGCTCACA CTGAATCACT TCAATAGGGA AAGAAACAGT ATGGGGAAGA GTTAAGAGGA ACTGACGCCT GGATTGAAT CCTAGCCCTG CCACTTGATA ACCATGTGCC TTTAAACAAG GTTACTTGAA CCCTCCAACT TCAGTTCTT CATCTATATA AGAGGAATAA TGAAATTGTG TTATCTTTAT CAAATTGATA TGGAAACTAA ATGTAATTCA ATTAGCATAA GTCAAGGACC TrAGAACAAA GCCTGACTCA TCAGAAATTC TAAGTAAACA TTAGCTAGTC TTCATATTAT TATCTTCAGC ATTATCTGTA GTGAGAATCC TTAAAGCCAA ATAGGTGTAA CTGGGAATGA CCAGCTTAGT CGGGAAATAA CTATCACATC AGAGCCCCTG AGTCTACTAG AGTATTGGGA GCAAGATGTT CAGAGAAAGA GTGGGTCTCC ATAATAAGCC TTCTTGCAA GGAGAGAATA TAAAAGTCTA GGAAGCATTT TGACCTCAAT TCTGTCTTCT ATTCTAGCTC AGTTCCAGAA T=AACTCT TGATITTG ACAACCCTCT CCAGAAACTG TATCTATTTC CCTGTTCTGA TTGGTGGTAC AATAGGTAAA TTAAGACTT GGAAATCAAA GTITTCACAT TTrAGACCCT GCCATGCCAT TTAGTAAACA GTACAACTTT CATGTCTTAT TCCTCATCTG TCAAATTTAA GCCATTATTG CTACCTrGCT CTAGAGACTT CAAGGAAGAA TGGACTCAAG GAATCAGAAG AA'ITI'rGTA TTTGGAAACT ATATGAGATG AGATTAGGGA GAAACATGGG AACTAAGAGA AAATGTTATC TIT I CATT GATAAAGA GTATCTATTA TATATCAAGC ATTACTCTGG GGCTTGAAGA GCTTAGATTT CACCCTGTAG GACAAAATGG TAGGTAGAAA TrAATGGGTG GATTGTCATG TATGTGTGAT GTGTTAAT TGCIT11AAT TGATCAGTCT CCCTGTAGTA TGAATAATGT ATTTGAGGGG AGCTAATTTA AAATTGTGGA ACTCATCTAA TAAACTATTG CAAGAATCTA GAAGAAAGAT AATGACGGCA ATGGTAGTAG AGTTGACAAG TGGAAGACAA ATTAGAAAAA CACTAAGTTG TAAAAATrGG TAGAATGTTA CCCTGCATAA ATGTTGGGGG AGTTAAGAGA GTCTCATACC AGGGTGCCCA TGTAAATGGT GATTCCACAT ACTGAGATAA GAAATACGAA GAGAAAAGCT GACTGGGAAC AATTGGTT ATAGTCTFF= AAACATCCCA AAGGACATCC TTAGCATATT TGAGTTCAGA GCTGGAGATA GGCTrATCAG TCCAAAGATC ACATAGATTT GTGAGTCCGC AAAAGTCAGT AAGTITGACC AAAGGATACA TGTAGATTAG AGTCAGAAGA GCAATATACA AAAGACAAAA GCTGAGAAAT TATAGTAGTT TATGGTCCTG GATAAGTGCT CATGAAGGAT CTCAGGAGAA ATGATCACAG GTAGAAAGAA TGAGAAAAGA GTGATATGAG AGAAACCAAG ACAAAGAAAA GTAAAATGT7 AAAAATGAGT GAAATAGGCA TACCAATAAT TAAAAATGAG TAAAATAGGC ATACCAATAA CATAAGGGTr AAAAAATAGA GTTCAAAAAT GGGGTGAGGG TAAAGTATTA GGAAGGAGTC ATGGCCCAGG GATCAAGTGA AATGAGTrAG ATCTATAGAT CTATITCAGT TGGTTGACAT TTAAATGTAT TTTGGTTTTA ATTCTTTATT GTTTACAAAC ATTGCTIr TAAAAAATTA AATTGTCCAA TTCAATTCAG GCTCACAAGC AAGTGCCTCA TATATACAGG CAITTGTGG ATCCCAAAGA TGCAATGATA AATAGGACAC TTACTGATCT CAAGAAGTIT TCAGTACCAG AGGAGACGGA CAAGTGAACA GATGAC1TTCA ACATAAGTGG GAGAAATGAG GAAGAAATAT GTGGAGCTAT CAGAACTAAG AAAGCTTCCT AGAAGAAACT GTCTTTGAAC AATGTCITAA AGATGACATG ITITGGCC ATGTGCAAAA TGAGAGAGAA GGCCACCAGC AAAGTCAGTG TGCTACAGAG CACATGTGTT AAGTGTGGAG AACTGCAAGA AGGAAAGGAA CTACTAGAAG GAAAAAGCAA GATACTTTCT GGGTAACTCA GCCTCCTAAT GATAAATGGC ATAGTrTCTT CCAGACCTTA GAGTTCTAAT TAATCTAACA AGCTCATTAG ATCGTGAGCT TCTrGAGAGC GGGAATCTAC CATGCTAATT CCTTATGGTA ACCCTGACAG CITITATCCC AACACTGTGC TTCTTGTGGT ACTCAAAAAG ACTTGTTGAG AAGTGAGTCG AAACTTCATG CTGACTTATG AAATCTTTAC GGAAAGGTAA CAATATTGTG AAAGCAGAGC TTCTGATCA AAACTTCCCA TTTCTCAGAG TGGCTAGTAT CATTGTTC CAACCAGCTT CATGATAAGC TATAATGATT CCTGTGACTF TACCTAAGAA GAAGCAAAGA AAGGAAAGAG ACTrACCAAA CTGACACTGG GGCCCATAGT ACCCCACATC ACAGTTGCAG GTGTAATTAT TGATGATTTC TACACATTCT CCATGGCCAC TGCATGACCA GGGCTGGCAA GAAGCITTAA GGAGGTCAGA AAAAAAATAT TTTAATGTGA TTACAT=TA GTACTCAAAG TCATTTCTTT AGACATAGAT AACCITIGT CTGAGATGAT TrAAATAATC AGGAAAGGTT TATITTGTAAA TTCATAGCAT AAAAATCATA TGCTAAAATT 7TTACGTATA AAATACACTA AGCATATAGT CATAGGCATT TATTTGCTTT TGGAATGAAA TTACCAATAC TAATATrCTG TAACACITAT AGGAAACTTA GTGGCATACC TFGAAACTCT TGAAATTACT TGTITI1iAAT GAGTGAGAAG GTTAAATGAT GACCTGACCT CAATCA'TC TGCATGCAAT TATTTCTTGG CAATCCCTIT CTTATAGAA ATCAAAGATT AAAAAGTCCA AATTGCTAA AACGGTAGAG TCCAAITTAT AAGAGACCAA ATTAACTATG GTTCATTATT AAAACATCAC TTGGAAAATG CTGGCTGTFT TGGAATTGTA GAAGATTTA CAGAAATATT CATACACCAA AGATAGTGCA ATl I iATAT AAAATTATAT AAGGTTAGAC CAAGAAGGAA GCACGCAGCA CCACACTCTC TACTTCACAA TGTGAAAACT GAGGTGATGT GAGCCTAAGT TTCCAACTGG CCCCAGCTGT CAGCTTCTCC TCCCCTGCCT TATTATCAAA GGCACTGATT GTCTAGCTCT TCCTCTGTAC TTCCTACGTA GATCTATCAT TTTGATGTAA CTTGATTTAG GGGTATAGCT TTTGTGCACA GGGACAAATC TTACACACCA AAAATCTrTA GGAGTGACAC GATGCAAGAT TATATAGAGG GCTAGATGTA TTAGAATG AACCAGAAGC TGTTCTCATC CCCCCACCTT TCCATGGGGT AAATCTGAGT ATTCTCT[AA CCGTGGCCCT TCCTGAGTCT GAGGCAGCAT AGCCGTCTrG TCACTCCCTA CCTGTGTAAC AGAGGGCTGC CTTTAGTITG TGGCAGGCGT CATCGTTCCA TTTGCCTGCA TCTFTGTFTC TCTTGATATA GATCTCCACG CAGTCCTCCT TGTTCTrCrf GTTGTTGGGC TCACCATCTC CCCAGTTCTC TGCTTCTrCA GTAAGAGATr TGTTGGTTCC CACCCACGTC CATATTCCTC CTATCTTCCG GATTCCTATC CAGTAGTAAG AACGACTGAA AGGCAGAGTC TTCTCCAGAT ACTCAA1TTC CGCCTTGITT TGTATGGCAA CTAAATCTGT GTAATTGTCT CGGCAGAATC TTCTAGCCCT TTGCCAGTTC ATGGGrTIT CAGAATAATG GTAAGTCCAG CAGTCGGTTC CATGATGTGC CAGGAAATCT GCAAGACATC AGTGTGACCT ATGCAGACTT ACATAATGTT ACAGCTAAAA AGAACCTAGC ACTACTCCAG GCTGAGCTAG ACACTTAGAG ATGAGGAAAC AGAGCCTAAG AGTGTATGTG ACCATCTCAG GATCACAGAA TAGTrGTTG CAGATTTGAA GTAGAACCTA GACCTTCTGG CITGAATATA AGATGCITIT ATCTAAGGTT CTATTrGAAA CAAATTTAGT GGTTTCTAG GTTATTTC TTATTAATTT TTCTCAAA ATTATTCAG GTGAAATTTA ACCAACATAT TTTAGACATr CATATTTCTT TTTCTTTGTA GCTGTTAATG ATTTACAACT AATTACCGTG TAATATCATA TAACTATACA ATTACGTAT ACITITIAAT CCTGGAATCA TTTCTTGAAG GCCAACACAT ATGTACCTAT GGGAGAAGCA TAATAAGGAC AGGAAGAACA GTGACATACT ThrAAGTAAC CTCTIACA TAAAAAACAT TTTAITTTAC CATAGGAAGA ACTGCTTCTG GAAAAGCCCA ATATACCACT CAACTCTTAT ATATCTAACT GTATAATTT TAAAAAGAAC AATTTACAAA GCCAAATGGT ATAGGATTAT GAAATTCATT AGATCATGT7 CTATACACAA AGAGACTCAA CTGATGATGT TTAATAAACA TATGGACCCA TCAAATATGA GGGCFTGAA GATATCTAAT TAAACACATA ATTACACAAT GACTTCATAA TAATATATGG CATTCTAAGC ATGGTATGAT CTACATGAAT CACTATAA TACAGTAAAG AAACAGATAT AATTGATGGT AAAGAGCATC ATAAAATAAA CATTTGAAC AGAGT=TTGA ATGAGCATTC CACTAGAATG CAAGTTCTAA GAGGGAAAAA ACTGTTGTGT CCACTGCTGT ATCCTTAGTG CCTAGCATAA ATTTCACACA TTGTAGGGAC TCAGAAAATA CCTGTTGTAT GAAAAGAGCA CTAAGTTTCT ATGTGACACA GTGCAGACAT GGCATAAGGA ATGTGTGAAC GGGAGAGTTA GCATGTTGC TTGGCTAGAG CTGAAAATCC AGGCTAGGGA GAAAGAAGAC ATTAGITTAC TTAGGAAATG AAAAACCAAG TTCAAAGCTA TTGCTGGAGA GTCTTCAAGA ATCAGATATA AAATTTGTCA CAACAATGGG AGAAGGACCA AAAAATGATA AACCCCCGTC CCTTAATAAG CTCGTATTGT AATTGTAGAA ATGACATTAA TGTACACTGA ACTATGAATA AAAAATAGAA AATGAGGTGC TAAATATTTG GTACAGATTG TAAGTACCTT AACAGAGATT TCTTAATTAA CATTATrCCT TTATAATTGA GGGATTTTGT GGGGTTATTG GGATTTGAAC TCTACAGCAT GGGCTATTAT AGGTTAAAAA TAGTGTTCAG GAGTTTCTGG GGAAGAACTA AAGGTAAGAA GAAAAGAGAT GTTTACAGAA GGGATAGAAT TAACAGCTCr GTGAAATAAT TTTCCCTTAG ACTATGTATA ACTAGTGGAT ATTAAGAAA AATGAATATA WO 00/09525 PCTIUS99/1 77-12 EI'I-109 156 AGTAAAATAG ACTTAGCGAT ATATAAATAT CATAACATAC CACAACAGAG CA FrcTCCAC CCCCACAACT TGAAkGATG'TT CCATAAGTCC CTCTGGGTGC TCTGACATI CCATGGAAAT ATCTGCAAAT GAAATACAAA ATrATA FITA GATGTATACT CT[AAACCAC ACA ITATAG CCTIGAGGT GGTGCTrACA AC'IMCTrAA TAATCAGAAT AAAACACATA TGTCTACTAA CCCTGTCTGA GGTAACAGGT F7CTCAGACA TAGATGAAAA ATrrACTrCAA A FFACATCA GAACTGATGC ACAGTGT 'TTGTrCTAT 'I=A'ITMA CGCTIAGTC TCAAGTrGCT AATCGGTACT GCCCrGAATT ITCrATGG IT1GGTAATT 'ITATACCTG CTCTGCT GAGCTA'ITAG ATAAAACTAT 'ITAATAMTA CTATGTATAT 7TTAAAGT ATITG IGCTG CTTAATTAAC TATTGATGCT TATATrFAAT GTTATAGCCT CACTCTTGAT CATAATGGGT CAATGCCTCA AATACCTAAA AAAAAAAAAA ATTAGATAGC CAGACACCAG GAAAGAAAAG TATI7rCTIM 1TAATAAAA AGAAATACCT TGAGCAA CTGAAATGAC AAAGTCACAA A'IMCCTGCA CACCTAAAA TATACTrAAT GTAAATGACG AGrrAATGGG TGCAGCACAC CAACATGGCA CATGTATACA TGTGTGACAA ACCrGTATGT TGTGCACATG TACCCTAGAA C=AAAGTAT AA'ITTAAAA AAATTCTATC rrCCAAAGCA TATCACICT CAGGTAGACA CAGTG'IMAT TGCAAAAGAT CTGAMhCAA TAGTA'I7rCT TCAAGAGTCT CCCCAGAGAC AAAGTCAAGA AGAGGAAATC AGCATATCFG AGAAGAAAGA 7IrFCAGGATC ACFTI1r=G AGGGTCTGAG AAAATG'ITA GMf7CTATAT TA7AAAAC CAGAAITGAA ATGGGGTGAT TC~TATCC= GCCACCTGCC TCTACAACCC CAAGAGTI7rC TATCTGAGCA TCTAA.ACGTC TAGGCTG AAAGGCrCAC CATGGC'=G CITGGTC=T CTCAG7Crr TCTGCAGCCC ATFGAGCCTC YrGACTrAGC ACAAGGGTCT CAGGTCC'T7G CCCAAAGGGA GTGTGCTGTG CTGCAGGTAG ACTGCACTGA ATGTCAACAG AAAGCCTTGC 'IMC'ICAT TTCTCTAACC CAGTCTCACA TCCTCCTCCT CCTCCCCTI TCCCTCCCCT TCCTCCTGCA MCrrCrMC CTCMTCCCC ACCCCMICC TAGACTGGCC TCTMTTGCCT CCCACTGAGA CAAAAATGAA CTGCTGATCA GAAAGTAATG TGACTAGATT CTCT-TTCCT TCCCrCCM T[UATCCTrCC TTCCATTCTC CTATGCATCT TrCCrrACCC TCCTCCTCCT TCACfCAI1G TTfGTrGV]TGT TC~rTCITCCT CTMITC CTCCTGCTCC TCITCrTCTA crrTc'rr7 yrCrrG'ITr TG1T7GGTrC FrG~rCrCCT CTTCCTCCTr CTCTCTCTCC TCCTCCTCCT TCTITCCAC CACCCTCCCC TATCTITC ATAAATGCTA AACTAACTCT TGGCTACCTG TGGTAAATGG CCCTrGGAAA TTGCAAATAC TACAAATCAA AACTGCA=F CAGACATATr TATGATGTIT7 GCAAAACTC AGTAGAGCTA AGCAGTGGAC TrGACTCGT7 TCGGTrCCTr CACCTCCGTC TICCTT7GCT CACCACCTAG TGGACGTCCT TGT7AGTGGC ACTrCCTGAA GflAACCCCT GAAGAGAGCC CATGCTCTCT AGC'ITTCAC CGTGTAGGT7 TGGGAGCCTA CAAGTACCIT TAATAT7CTr GGACTATAAA ATGAGATGGT TIATAAGAC TGCATGTGAA ATTAGGACCC ATATGATGAA GGACAATAAA AAGGAAGACC CACTGATGTG AGTCAATGAG TCAAATGCAA ATCAGAM~G CATITWAGG AAAATAATAA TAACAACAAC AAAAACTCTG AAGCTCAGCG CCCCATAMT ATTATA-frGT TrAATCTF1A TAACAGCTCT CTGCTATAGA TATGATTATT ATCCCCATrC TAAAGAGTCT CAAAGAGGTT AAGAAACAAA TTCAAAAACT AGCGAAAGAC AAGAAATAAC TAAGATCAGA GCAGAACCAT AGGAGGTAGA GACACGAAAA AGCCTTCAAA AAATCAATAA ATCCAGGAGC TGCATITGA AAAGA'FrAAC AAAATAGATG GACCACTAGC TAGACTAATA AGAAAGAAGA ATCAATAGAC ACAATAAAAA ATGGTAAAGG GGATAITACC ACTGATCCCG TAGAAATACA AACTACCATC AGAGATTACT ATAAACATCT T7ACACAAAT AAACTAGAAA ATCTAGAAGA AATGGATAAA ITCCTGGACA CATACACCCT CCCAAGACTA AACCAGGAAG AAGTCAAATC CCTGAATAGA CTAATAACAA G TCTGAAAT TAAGGCAGCA A17AATAGCC TACCAACTAA AAAAAGCCCA GGACCAGATG GA7rCACAGC CAAATTCTAC CAGAGGTACA AAGAGGTGCT GGTACCATTC CTCTGAAAC TATrCCAGAG AATAGAAAAA GAGGAACTCC TCCCTCACTC ATATGAG GCCAGCATCA TCCTrGATACT AAAACCTGGC AGAGACACAA CAAAAAAAGA AAA'ITrCAGG CCAATATCCC TGATGAACAT CA ITGCGAAA ATA~rCAATA AAATACGGCA AACTGAATCC AGCAGCACAT CAAAAAGCT7 ATCAACCACA ATCAAG17GG CTrCATCCCT GGAATGCAAG GCTGGTFCAA. CATACACAAA TCAATAAACA GAATCCATA CGTAAACAGA ACCAATCACA AAAACCACGT GATrATCTCA ATAGATGCAG AAAAGGCCTT GGATAAAATr CAACACCCCT TCATGCrAAA. AACTCTCAAT AAACTAGGTA TTGATGGAAC GTATCTCAAA ATAATAAGAG CrA ITATGA CAAACCCACA GCCAATAGCA TACTrGAATGG GCAAAAACTG AAAGCGT7CC CMTAAAAAC TGGCACAAGA CAAGTATGCC TCTCTCACCA CTCCTGTCA ACATAGTATT GGAAGTrC7G GCCAGGGCAA. TCAGGCAAGA GAAAGAAATA AAGTGTATrC AAATAGAAGA GAGGAAGTCA AArrGTGTCT GT17GCAGAT GACATGATTG TATATIAGA AAATCCCArr GTCTCAGCCC AAAATCTCCT TAAACTGATC AGCAA=FCA GCAAAGTCTfC AGGT7ACAAA ATCAATGTGA AAAAATCACA AGAATrCCTA TACAGCAATA ATAGACAAAC AGAGAGCCAA ATCATGAGTG AACTCCCATT CACGATTGCT ACAAAGAGAA TAAAATACCT AGGAATCCAA CT7ACAAGGA ATGTGAAGGA CCTATTCAAG GAGAACTACA AACCACTGCT CAAGGAAATA AGAGAGGACA CAAATGAATG GAAAAACATT CCATGCTCAT GGGTAGGAAG AATCAATATC ATGAAAATGA CCATACTGCC CAAGGTAATT TATAGATTCA GTGCTATCCC CATCAAGCTA CTACTGACT 'I=TCACAGA ATTAGAAAA.A AACTACM~A AAM~CATAT GGAACCAAAA AAGAGCT1TGT ATAGCCAAGA CAATCC7AAG CAAAAAGAAC AAAGCTGGAG GCATCATGCT ACCTGACTTC AAACTATACT ACAAGGCTAT AGTAACCAAA ACAGCATGGT GCTGGTACAA AAACAGATAT ATGGACCAAC GGAACAGAAC AGAGGCATCA GAAATAACAC CACACATCTA CAACCATCTG ATCTTGACA AAGCTGACAA AAAGAAGCAA T7GGGAAAGG AITFCCCCA'Fr TAATAAATGA TGrrGGGAAA ACrGGCTAGC CATATGCAGA AAACTGAAAC TGGATCCCT CCITACACCT TATATAAAAA 'FrAACTCAAG ATGGATTAAA GACrrAAATG GAAGACCTAA AACCATAAAA ATTCTAGGAG AAAACCTAGG CAATACCATT CAGGACGTAG GTATGGGCAA AGACTrCATG ACTAAAACAC CAAAAGCAAC AGCAACAAAA GCCAAAATTG ACAAATGGGA TCTAATTAAA CTAAAGAGCT TCTGCACAGT AGAAAAAAAA AAACTATCAT CAAAGTGAAC AGGAAACCTA CAGAATGGGA GAAAATITI GCAATCTATr CACCTGACAA AGGGCTAATA TCCAAAATCT ACAAGAAACT TAAACAAATT TACAAGAAAA AACAAACAAC ACCATCAAAA AGTGAGTGAA GGATATGAAC AGATGCTTCT CAAAAGAAGA AG=ITATGCA GTCAACAAAC ATATGAAAAA AAGCrCATCA TCACTGGTCA TFAGAGAAAT GCAAATCAAA ACCACAATGA GATGCCATCT CATGCCAGF AGAATGGCGA TrA'rrAAAAA GTCAGGAAAC AACAGATGCT GGAGAGGATG TGGAGAAATA AGAATGCM~ T17ACAGTGT7 GGTGGAAGTG TAAATrrAGTrr CAATCATrGT GGAAGACAAT GTGGCGAMT CTCAAGGATC TATAACTAGA AAAACCNT GACCCAGCAA TCCCAT7ACT GGGTATATAC CCAAAGGATr ATAAATCATr CTACGATAAA GACACATGCA CACTTATGTT TATTGAGGCA CTATTCACAA CAGCAAAGAG 1TGGAACCAA CCCAA.ATGCC CACCAATGAT AAACTGGATA AAGATGATGT GGCACATATA CATCATGGAA TACTATACAG CCATAAAAAA GGATGAGTTC ATGTCCITG CAGGGACATG GATGAAGCTG GAAACCGTCA 'TCrCAGCAA ACTAACACTG GAACAGAAAA CCAAACAT7A CCCAT7CTCA CTCATAAGTG GGAGT7GAAC AATGAGAACA CATGGACACA GGGAGGGGAA CATCACACAC TGGGGCATGT CAGGGGATGT GGGGCTAGGG GAGGAACAGC ATFAGGAGAA ATACCTAATG TAGATGACAG GTTGATGAAT GCAGCAAACC ACCATGGCAC ATGTATACCT ATGTAACAAA CC7GCACGTr CTGCTrCATGT ATCCCAGAAA TTAAAGTATA A'ITAAAAAA AG'IMAAAAA AAGAAAGTITG CCTTAGTCAC ATAACTAGTA AGAGACATGG T7GGGAATr GAACAGAGGC CAATCAGTTC CAAATCCATG CT=~GATCA TTAAGCTGAA CTTATGGCAG GAACrGGAA GACATGGTAA AATGGGGAAA AACGTGGAGC CAGGGAGACT TGTGAAAGTG CCAGTGCTCC CACTATACCC TGAAAGAAGT ATCTAGA=T AC 1IIICT AAGTCCTCTC CTCTAATTCT CTCAATCTCT CTCrCTC'rr CTCTAAGAGA TGGGAATGCr GCTCTGTCAC TCAGGCTAGA GTGCAGTGGT GCGATCATAG CTCA F7GCAC TCAAGGAATC CTAGGGTCTA GTGCCCCTrC TCCCrCAGCC TCCCATGTAG CTAAGACTAC AGGCACATGC CCCAACCCTC GACTAATMT TI'ATTT AT=TGTAG AGACAGGATC TCACTATG'IT GCTCAGGCTG TAA'ITCTGTC TTGAAG=TG TCCAATCAGG C'IMCAGCCA CACCAATTCC CTGAGACTGC TCTCACCAAG GTCCTACACT TCACTAACAC AAACAGCCTA TrCTCCATCC TCATcrrACT TCACCAGGGA GCTCCrGG'Fr FCCTCCTAC 7ITCACTGGCT AMCTCTG TATCATGTGT TGATTCTCCC TCATCTrCCCC AACCrCCAAA CCCTTGGAGT ACTCCAGAGA TCACCGCM~ GCTCTCTGT GTCTAACCTC ACTAACTrGG TGGTCCAATT CACACTCTG ACMTGAATA CCAT11TAAAT GCGAACGAAT TCTAAATrCT GTACAACCAG AACCAT7CTC CTGTAGCCAA WO 00/09525 PCT/US99/17712 kEPI-109 157 ATGCCTACTC AACATCTCCA TCCCCAAACA AA=~AG FrG T-rCAATAAGC C1?CTCATATI7 T-rACATATCC CAAACTGAAC TCGAAMh CTCCTCCAAT GTGTAGGGCT CTTCCCACAG CCTICCATC TCAGTGGATT ATAACTCCAT CCTTCCAGT7 ACTCAGACCA AAACT1TGG AGflAACTGA GACACCTCTC TITITITCA CAAGTCATAT CCAATGTGTC AACAAATI= GGTAGTGGAA ATAYrGCGGG A'Tr=AAG AAATCAGAGA GACCGATGGG G FrCAGGAGG ATATITA FA T7TAGGTGCA CTGGCCAAGT CAGATTAACA TCCAAAGGAC TGAGCCCTGA ACAAAGAG1r AAGTI'ACCTr TAAGCAnI7 TGTGGGGTGG GAGAGAGGGG TATCTGTGCA GGGGGAAGCA TACTACAGAA GTGAGAAATA AAGACAGTTA 'FrCAATTAAT TGAGACATGC ATTACATCAT 'FrCT-rACT TCAAGAAGAA ACATG=I~G CGACTTGAGT 'FIATCTGTCT AGTGACCTTrG CAGCTGCACA GCTAGAGAAA CAGGGTCT7C ACAATGCCrG GGAAAGGAGG AGAGGTAAGT CTCACTAGCC ACAGAAAAAC AGGCAGTTAA 'TI=AAAGG GCTCCAGCTC 'I=CTC=fC TCAGGGGGAG TrGGG=FTG FrACATACAA CTGAGM~CC G=rACACAT TAI=rAMTr CITAAYrC CTGTFrCCAAA AGAAGCCAGA TACAAAAGGT TACATG7TGT CTGArrCCAT TTATATGAAA CATATAGAAG AGGTAAATCC ATAGAGACAG AAAc3TAGATT AGAGGT7CCC AGGGGCTGAG GAAGAAATGG GGACTAACTG CT7ATAGGGT ACAGAG7TT CTrCTGATAA AAATAT=TG GAACTAGATA GACATTGT TAGGCCATTC T7GCAUTGTT ATAAAGAA FT ACCTGAGACT TGGTAMTTA TAAAGAAAAG ATG'IMAATr GGCTT1ACACT TCTGCAAGCT TTACAGGAAG CATGGTGCCG ATATCTGCTC AGLTTCTGGT AAGGCCTCAG GAAGCTrACA ATCATGGCAG AAGGTGAAAG GGGAGCAGGC ATATCACATA GCAAAAGCAG GAGCAAGAGA GGGATGTGGG GAGGTGACAG TCACTIIAA ACAGCCAGAT =TGTGAGAA CTCATITCACT ATCATGAAGA CAGTACCAAG AGGATGGTAC TAAATCATTC ATGAGAAACC CCACCCTCAT GATCAAATCA CCTCCCACCA GGCCCCACCT CCAACACTGG GGAT-rACAAT TTGACATGAG A ITGAGTGA GAACACGGAT CCAAACCATA TCAGAGATGG TGGTFATACA ATGCGATAAA CGTCAOTGGA TTGTACACT7 TAAGATGGT7 G=TATGTT GTGTGAACTr CACCTCAATA AAAAAAAATA 'ITrAATGTAC AT7CAGCCAA AAGAAGATI1 GGAATAGGAA AGGTCATGGA GATATAT7AA CAGCCA TTG ATGGGTGGTA AGGAAAAGAG TGGTrATrAG ACTGT1TGT GGCCCFCAAA AGGTAGAACT AGATCGAGTT GGTGAGCAT7 ATAAAACCAT CACAAAACCC TGGAGAGAGG ACCCAGTGCT GAAGAACCGT 'TGCCTGCCA TGAGACATGA GGGAAGTACC AGTGAATGCC ATTGAAAGCA GCATCCCTGG GTCCAAGGGA TGGTCAAAGG ACCACTACCC AACCC'TCCC TAGCCTACGC CrCCATTACA GATGACCGCA AGKIT7A=IT GCTCATrGCT GCCAACCAAG GCTGCACTCA CTGCAGTrGC TATCAGT-17A TCATGGGTAA AAGGAATGTG CAGTAGAGAA CTAACTAACT GCCCACCTAC CTCCACAATC CTATCAGGAC AAATCACCAT GGCTCACAT TCCTTACATT TGGCATGTAA GCCCCTCFA CTGTCTGTCA TCTATCTCCT ACACAGTrCA CCTAAACTGT TCTCTCCTGA CCCAACCTTG ATITCATCC CAAATGCTrC CIGCCATCT CTGGGAflCC TGTCTCACC ATCACCAAAC TCCCCTCAAT =~CCAGMr CCTGTTCAAA C=ICTCCT ACCTCCTIXIC =TGTCA'FrA GCCCGACTGC CTCCCTAGGA CATCACT7CC CCTGCAGATC TCTCAAGATG ACAATA'IMA FTCTCCACAC AGCACATACT TCAGGGT7GG AAGGCAGGGG CAATCTrCTC C=TATAATG AGTGCCTCTT ATATATGTIT ATrCATCTGC CCTCITGTAA AACACACACA CACACACACA CAAAGAAGAA ATAAAATAAC TCTG==CT TGAAGCITrGT GACACTGAGA TAAACCATCT CACTGTCCTC AT7GTAGTGA CCTCTCAACT CCTCATGCAA GArrGG=T- GGCACCTAGT TCCTGATCTT CC1TCCCTG TAAGCACTTC TCATAGTCTr ACGGGAMIC ACCATCCATG GCACAACCAA TACCACAGCC CAGATCCTCA GCTCTCCAAT GACA=T1CC TCCACTAGAC T7GAGCTACC TCCITCCCTA GGCACAGCCT CAACCI'CGAC AACACCTAAG ACTGTACCGT CTCTAAAGTC ACATGTrCAA ACAC'rTCACT CTTAACCAC TGTCTrCCTAT TCTrGCAAGT GTA'I1rGcTCA AGTATCTCAT TGCAATGCTT 'IMACrrCTA CCTCATTGAA CCTCCAGGCC ATTAAACATT TCCTTATFC TAACCATCAG G1T7CCCUr A=~G'ITGT 'rrG'rIA'I GTITCTr1T Trrl-I= TGAGACAG GGTCTCACTC TGTTGCCCAG GCTGGAGTGC AGTGGTATGA TCTCGGCTCA CTGCAGCCTC CATCTCCCTG GTITCAAGTGA T7CTCATGTC TCAGCCTCCC GAGTAGCTGG GACTACAGGT GCATGCCACT ACGCCTGGCT AAGATITGT AT7MTATTA GAGAAGGGGT nITGCCATGT TGGCCAAGCT GGTCTCGAAC TCCTAACCTC AGGTGATCCA CCTGCCTCAG CCTCCCAAAG TGCTGAGATT ATAGGCATGA GCCACTATGC CCCACCTGGT TTrCTCC17AT TrAnITCAAG TCTATGCTGC ACTATrAAAA CTGCCTGAC AAAAA FFATA ATAGTGAGAA AATTATGACA GTGAAAGAGA TCTGAAATAA TCAACCCCCA TCTGCCTF ACCTTCCAGA CTGCCCT7AA TAAT7CCTGA GCTTGGGCCA AGCTATC=f GGCAGAAAT7 TAGI=ATAG 1TIAAATGAT AATAGCCCT CTCCAAAACT AAACTGC=T TGTAAAACTA ATAAAAGACC ACCAATGAAA GG ITAGGAGG ATGAGAGGAG CCTGAATTCT GCTAAGGTGT AGATGTAAAC AATTACCAAC TGT7ATTCCG GAGGTCACAA GA'TGCAAC ATCGCCAATr ACTCCTGCAG ATAACAGCAC TATCATAGAA TCTGATTGGC CT=TGAGAT GTCTITCAG ATTCTACAT TrCAACTGGT GGCTCTACCT GGACCCATCA ACAAGTCCTG TGGCTCCACC CAGAAGCAGA CT7AACATGC ACAAGGACCA =IrCCACAC CGCTATGATT GCATCCCAAC CAATCAGCAG CAACCATTCC TCTGCCTGCC AAMTTATCCT TGAAAAATCT TAGCC=AGA ATITGGGGG AGGCTGATI17 CAGTAATAAC AAAACCCCGG TCTCCCAT-17 GGCTGGCTCT GCATGAATfA AAT~CTFCT CTATFTGCAGT TCCCATCTTG ATAAATCACC TIATCTGGG CAGCAAACAA AAGGAACCCA TrGGACAGTr ACACTGT7GG CAGATATATC TrGcTICCAA AATrGGNT~ T7G=rAATG AA'7TrTCT G==TTGA TATI17ACAAC TGTGAATGF[ GTGTCTGAAT TCTC'TATT TCTTGTFGAA AAGAACTATA 'ITGCTACAGC CAGTACATAC AGATGGATAG CTAArI7ACTC AACACGGGGG GATGTGACCA TCACCGCACT GTGCAAATGA ATGTrACCCA TTGTCCACT- TTCCCAAACT ACATAGTGTr ATATGGTATA TGACCCAATC AACGGTGGCA AAGGTCCAGA AATACCACAT AGACATCAGG GACAC1TAA ACTAATCAGC CTATAGTCCT TITCAGTAA =~CCAAACC TGGTTGTGCA TCCAAATCAC 'TTGGTAACAT TAAAAAAACA AAAAAATATA CACGCAACAT TCGCTCCCAA TCCTACTGAA TCAGAATATT T-rGGGT17GGT TCAGGAACAT TCAGGAGTTT TrCAGGGTCC AAGcYITATA TAMT7GAGG TCTCT=TG AGAAAAGGAA CGTAAAAGCG TCITGCTIT ATAGATC77A CAAAGATGTA TTACCATGTA AACACATTCC TAGGACCCAG GCCCrrGTAA ~TAAAGGTr TATCTAAGTA ATGGGCCCTG AAGCIrAA Fr TTCATTATCT TCAGGGCAAA 'FIACCTGTGG G F7AGGG T1 AGGAATATAT CTCTCTGTGT ATGTGTGTGC ACATTAGCAT GTACG=TGT GTGGA'TTT TTTTIT 7ITI=C TGAGACAGAG TCTCGCTCTG TCGCCAGGCT GGAGTGCAGT GGCGTGATCT CTGCTCACTG CAAACTCCGC CTCCCAGGCT CAAGCGA1TC TCTGCCTCA GCCTCTTGAG TAGCTGGGAC TATAGGCACG CACCACTATG CCCAGCTAAT FI=GTAT17 TTAGTAGAGT TGGGG ITrCG CCATGTrGGC CAGGATGGTC 1TGATCTCTT GACCTCGTGA TCCACCCGCC TCCACCTCCC AAAGTGCTGG GATITACAGGC GTGAGTCACC ATGCCCAGCA CrrGTGTGGA TGTITAAGC TCCCAGGTGA GTGAATACAA AACTAGATCT TrCCCrCTG TAGCATCTGT ACTG=~ACT CTATGCATCT CAATA'LT= TCTI=AGTA TCTICCITT 17CrCTCTTA TTACTTCCTC T7GTGCTATT 'IMACACCTC CI~r=AAA AAA'I7n=C CCT1TA=T CTATTGACCT TTAGCCCTCA CAATGATTCC TACAAGCCCC A'I=CTGTAA ATGGGGATTG AAATAATFGC TGGACTITG AGAGATAGAT ATATrAAATT GCAAACrGGC AGTAGTGGGG GCAG'TrGATA CATAACTAGG 7TFAAAGTC TAGCC'ITCTG AGACCACTCA T'rCCA=IGT GAAAAGTGAT TCTAC=CT7 AT-TATGAGCC AAAATATGCA TrCATTCACC CATGCATrGA =I~AT7CATT CAATAAATAT TTGT7GGATG TCCACTCTGT ATCAGGAATG TGCTAGG'ITC TGGGAATACA GCAATGAACA AGGTAATI= TCCCTACCCC TAAGGAACTT AGAGTAGT GGGGAAGACA GACATrAAAC AAACAATrGT GCAAGTAATA ATCTATAATT A1TA FrACA ATTAAAGGAA GGAAGAGACA TATGGATTAT GAGGGCATrA AAGAGGAGAC CTAGTGTAAG TAGCCAGTTC TCGTGAAGGG ACATGTATrA G~rGGAGT7C TCCAGAGAAA CAGAACCAAT GGTGTGTGTG TGTGTGTGTG CGTGTGTGCG TGTGTGTGTTr GGGGTGTGGG GGTGTGGTAT 7II=ATAGA AATTGTCTCA CACAA'17ATG GAAGCTGAGA AGTCCCATGG CCTGCTGTCT ACGAGCTrGAG AACCAGGAAA GCCAGTGGAA TACTTCAAAG TCCAAAGGCC CTGGAACCAA GAGTGCCAGT GTT7GGAAGGC AGGAGAAGAT GGGTGTCCCA GC'IAAAAAG ACAGTGAATT CACTc'r= GCTCTACATA GGGCCTCAAT GGGTTGGATC ATGGCCACCC ACATTGGTGA AGGCAATCCT CTTAGTCTAC CAATTAAATA CTAATCTCTT TGGAAATACT CTCACAGACA CACTGAGAAA TAATGTI=A TCAGGGTGAT AGAAATC7C TGGAGTrAAA CAATGGTGAT AGCTGTACAA WO 00/09525 PCT[US99/17712 EPI-109 158 TCACATACAT TI=AAAGGG TGCGTrrAT GGAAAGTGAG TI=ATCTAA ATAAAA I=C TAAGAAAGAG ACTTAACACA GAGATAAACA TAAGCACA~r TA'ITGTCAAC CITATAGTG 7rATGTCAAA TAGGTCTGAC ATAAGCITrAA ATAAATATAT AC'=AAAAA TrATAAAATA TITAAGTTA TAA1TIAAAA TTCTCAATAA AACTCAAACA CAAACCACAC TGGTAMTCA CACAGCTAAT TrCTAATGCA G FIACATAA ATA ITACAA CACTrAAACA AITCAAAGA AAATAACACT GTATrCCATA CATAGCCTGA TCACAGTAGT TG~rCTCTCT TA'I=CCCAG AGTIT=CTG CCCCITAAA AGAACCTCTG CTGT1TCrGAT CCFrATCACA TCTCTGTIT GACTG TGGC =~GflGTrG CCAGTGTTCA GCCAGAAC= CTCrGAAACT TMTTICAA CACATGCTAA GTTAATGGAA GTGTAGGAGA GTTIGATTC TCACACTCCT CAAGGCTAGA GCAGC'=GG CAATTACTGA CTGAGAA= rTTCATrGCCA GTGATCAACT GAAAACTGGA GATrCC' I IG GAATrGTTAA ATCTGCTTAT AAATAAACAT AAATGCTTGC TCACACAGGC ATrCCrCTCT TCCAGAGCAC CCTAACATAC AGAAGAAAAC AAATAGGGAA TAACTATrAG ACATcTCAT TCGTrAAAAA T~rACCAGAT GACTCTI=A CATGGTGAc3T TrCTA1TGTG AAnrTAAAAT =ICCATAAT ATACAAGAAT TATG IMACA TATCATATCT GACAAACATC IMGTAGGAA TGCAAAGCAC ATCCATCTIT7 CTGTATTC TT TrCCAACAAA GACA I1CATA AAATTATACC =FGTGTGTr TGCATIATG C'TrATrAG TrCAAAACGT TrGGCCTCAT GGAAGTT= CATCGTGGAA ACCACATATT TCTGAAAAAA TATCTGACAA TATACAAACC TrCCATrCAG TITI1ACTCr CCAATTrCTAC CATGTI=CA AAAAACAACT GTAGTAAAAA CACTCAGAAC MIATTCTGG TTAACATCAT GC=TGCTAG GGGACAATAG 'ITTCCCT!ITIr TGAAATAAAT T-rAAAACAGA TGTAACATAA ITG'rrAATA AACAATGAGG GGGTAATCTA GAATAAGTAA CTI=ACCAT ATCATAGTTG ACAGC~nI7A CAAG'TT AAGTCCCTAC CACACTTrGTA T-rGAATGAAG AAGTATGGAA GATTATAATA TATrCAATGC AAGTAAAAAT ATCACAATCC TAAGAACTC 'IMAAAAGC ACTGAATCCC ATAGGGATGA AAGTGArAA ATrGTGCATA GTAACCCTCG CACAGAGCAT TCAGTAGGAT TrGCACCAT7 AACAACCCTC CATGCATrT7G CCTGTGGGCA T7CAACATCT GTCATITI TAAG FrATAA TATTIAGT CATTTC CTCTAAACTC TGGATAATTA TTA'FrCA'fC TrATGACAGC AACTGTGTAA TCAGCTGTCG AAACACTGTG AAGGGCAAAA GAAAGAAAGC CACAAAATAT TGTG=ITCTG TGCCAAGAT7 TACAGCGAG CAAGGGAGAG TrAGAAAAGG AAT7CTGAGA TnTCAGAGTC TrGGTCrCT[r CACC'=GCT TGGAAGAAAA TATC='TCC C=CATrAGC CAACAcn7TC rrGATCCTGA GAGTAGGAAA GGGAACACTG AGTC1ITCA GT7GAAGGCC GTC=TGCCT GCTGGACT= GATCTATTGA AGTGGTGATG GGTGT7GCGG TICAGCCAT AAAGGCATCT GGCATAGTAG GCAAGAAGGG CCAGAGACCC GAGGAGAGTT ATVIrGTCTCT G FTAACTrCA GTGTATCCCT CTAGTrCCCC AGATGCACCT G1CTGTAA ATATAAACAT GCATGTCATC AGAACACTF7A ATATrCTGCA TACTGATCAT GACAACAAAA TGTACCTCT AACACAGACA CTCTCACTAG GATAGACCAT GTAGGAACAT CGAA17CTAT TCAGTTAGGA CAGTGATGAT GTCTACATAT TATACCTCTG TCAAAACCTA CAGAATATAC AACACAGCAC AGAGTGAATF CTAATGTAGC CTGTGGACAT TAATGAATAA TAATGTATCA ATAT7GGCCC ATCAG1TGTA ACACTAATAT AAGATGT7AA TAACAGGGGG AA'FrGAAGGG GTGGTGGGGA GATATGTTGG AACT=TIGT GCTICTGCT CAATIT=CT GTAAACTTAA AACCGCACAC ACAAAAAAAG T7rAn=AAT IT=~AAAAA GTA'rTCAGAG GGACT7GACC TITCCAAA'rT CTCTCAAAGC AGGTCGGAGT AGT7AAGAAC ACAAAT=A GAACCAGACT GCCAGAG1T GAATCCTGGC TACACCACTF ACTAGC1TG AGATrCAGA CAAMrACTr AACTTCTCrG TCTCATITC TrCATCTGTG TGATAAGAAA TAAAGTAACA GGCCAGGCCC AGTGGCTCAC GCCTGTAATC CCAGCAC=T GAGAGGCCAA GGCGGGTGGA TCAGGAGTTC AAGATCAGCC TGGCCAACAT GACGAAAAAA TACAAAATCT CTACTAAAAA TACAAAATr AGCTGGGTGT GGTGGCAGGC ACCTGTAATC CCAGCTACI'C AGGAGGCTGA GGCAGGAGAA T7G=TGAAC GCAGGAGGTG GAGGT-TGCAG TGAGCCAAGA TCATGCCACT GCACTCCAGT CTAGGCAACA GAATGAGACT CCATCTCAAA ATTAAAAAAA AAAAAAGTAA AAAGAAAAGA TAAGAAATAT AGTACCAGCC CCTATCTCAG AG~rCCTAGC TTAGAAAAAT TCCCAGAATA TAATAAGTGC AATGTAAGGG TCAGCTATCT TCATTATTAT TATCTATCAT AAATGAAATr ACACAATAAA GCTAGATCCG 'IrCI=CCT CTCCT7CTAC AAAAAATAAA GCAACTTCC AGAACAATAC CCAGGTGATG A'IMCTCCCC TGCTCCCrCC CTAAGATATT GGCAAG=TG GAGGG'rTCAA GGAGAAACAG AGCATGTAGA GAAGATACCT CTCTCATAAC CAMrGTGAT T7ACAAGTCT TACCrGATTC IIGAACTT AAAGGATGTA AGAAGGCI= TGGTAGCTrC CATCTGATC AAGGCT=GG CAGCTGCTGT GGAATACATG AGAACACTAG GTAAAGCACT GTCT'TCCAAC ATGAAGAGAG AAAAATATGT GGAATG FrCA ATGGCATGCT TTGTATAAGA ATGCAAC17A CCTGGCAGGA ACAAAMIC TrGCTGCAAA AGAAAAGACA AACAACCATr AAT7CAGACT AAATGAcTI TAAGGATATA TTAAATCCAG ATACAATATG AC F7AATrCA TCAAGTGTrG CAAACTCGAT GCTTCAGGGC CTCTGTAATA ATCAGAGCAC AAGCATGGCT CTGTGGCATC TAGGGTAAAA TGCAAAGTGC ACAGCCATCC AAAGGGCATA GCAGc~rCCT AATGCCAGCA AATAGCrACG GGGTCATCTr GCCCAA'rTCA GCTCCCAAT7 M~CATGAGA AGTCCAAAGT C=AA1TrAA ATGTGAGAT7 TCCTA'r=G TAAACGTCAG AACITAACTC AAAAATGTIT7 TAAGTACTCT TAAACATGTA AGCCAAACAA ACCATGAGTG TAGTCAGATG TGCTTCCATA 'ITCCITrATGA GAGACTCTCA AA TrAAGCC TGTACTCCAA ATAAATCTCC TFAGGAAGAA TITATCCAT TrT7CCT'TAGA GTGCTCATCA TGGCAGT7CC ATrGCACAAT TCCGGGAGGC ATCATATAAT TCAACATGAA TAGCACCCCC TGGAG17GTA CAATATTAGG CACGACTAAC A7n=AnrT CCTGAAACAC TTCCCACACT GAGTrGTACT ACTAACTCT'T T7C1TAATAC 'ITCTGC'ITAA TTATACTGCA 'IrATCCAG ATrCTAATrFA TrGMTAAAT CAGTAAGCAA GACCATGACT TATCAATGAG AAAGAAATGT ATITCAAAA ACATTT7GA AGTACATrCA TAAAC=CCT CACCTT=CCG TAAGCA'1C CGAAGCCAGA GGAGAAATGG TGCTAATGTC AGGAGGGAGA GTCCAGCAGC AGAAAGTCCA GCTACCAAGG GAATGT7GGA CTCAGTGGGA GCTAAGGAAG TAAGAGACGA AGAAAGGTCA TGAGGAAGAA T7GATG'FrAA AGTCTCTCCG TCCTGTCCCI' T7GGCCTIT TTCrGTACAT TCAITACTAG GAGCAGAAGA GCTATCTAGT TTAATACAAG AAGCAGAGAT GTGGCAT7AC AGGCCT=GA GATCTGCTCc AAGCCACCTr TGAAGCTATr TCCACCATTG GCAGGCAGAA CTCTAACTITG CCAAGCTCGT TCACAATACC ACACCACACC TTGGTrAATA AACACTGCAC 77G~TrGCrC TCTrGCTCTC ACTCCCTCT-r GrIMCCATr TCCCC]T7CT CCTCTCCTCT CTCTGTCTCC 7=I~CCAGT TGTCAGAATT CTACCCITTC CATCAACATG CAACTTCTGT 'TrMCTCTA TCCCCATACA ACTrAATA7 CACAACTTGT CAACCTGGGC GAACITCTG GYITGGATAT AATGAATAGT TGATTACTGT AACAAGATAG CTCCCC=T1 'TCT=AA TCACCAGACA ACCACCATCA ATCAATGCAT CACCrrCACA GGTAGGTAGC AGGCCAGACC AGTGTCCTGT GGCrCCACAT GTCCGAGCTG CAGAGCCATr GAGCGTCCAT CCrTCAGGAC AGGCGAACTr GCACACAGTG CCAAACACGG GCrCCCCACT GCAGCTCATG 'ITGATCTIC CCGGAACTGC CAGGC77GAA CAT=TACCA CrGCAAATGT TAGGTACACA GGCAGAG'IM CAGAAAAATC TACTGGAAAA c~irCCAAAAC T7GCT]rAAAA GTCAACAATG AATGTAAAGT GTAAGCGCTA CTTAGT=C AGCATGTAGG AAATrAGGAC CAAACCCCTT TGGGGCAATC TAGG TCAGA AACTIATGA AGTA'IMGAC CTGTACCCTA AAAAAGTCTG CACTCAATTC TACCTTGGCA GGAAGGAACC TCrCTGTCC ATrGTCCCTG AGATGTGCAC TCAAG FrGAG 7rGATCCATG TAATTCAAAT CCCTCCTCAC AGCTGAAGGC ACAAGAGGAC 17GTAGGTGA ATrCTCCAAT AGGGGAATGA GCACACCTCA CCAAACCCTT CGGGGGCTGG TGGACAGCAT CGCATCTCAC AGCTGGAACA CACGAGAGAG CACITAGAA GTrTG'I=GC AT~TCCAGCA ATACG=TCC CAAGGTAACC AAGTrCCCAA GCrCTrCAAT AGTTC1TF= ATCTfAAAAT AAAATAAAAA CAAAGACTGT ACCTrCACAT GTGGGCTCT CGTTGTCCCA CTCCCCTGTG GGGCCACA7 GGAGCCT1T7 GGATCCCI7C AACACAAAAC CC1TGCTCACA GGAGAACTCA CAGCTGGACC CATAACGGAA ACTGCCAGAA GCACTAGGAA GACAATTCAT GTAGCCTCGC TCGGGGTrGG ACAAGGCTGT GCACTGGAAA GCTGAGACAT CAAAATGATG GTCAGAAAAT ATrGCAGTGG AACTAGAGAG TACTGGCGT TTG FTGAGTG AACCCAGT7C ATrCAAGCAA CAC=GGAGA ACTGAAGATT CTrrrATAATr CCCTGGACAA ATGGGAAGAT GGCTGTG=T TC'rITIGAATr TCAGCCCCCT CACTGATCAT GGCACTAATr AAAAGACTAA TTAATCAGAA CA ITAGTTCC TGAGCACTGT TCTTCTAACA CACkAAAATAA ATTATGGTCC AAGGAAAGAT 'FrCACGCAGT CTGAGGACAA CATATGGGTC ATGGATGIT ATAGATGGTG CCAAAAAGAA AGAAAAGAAA GCACCCCTAT AAAA7IrGTC TG=~GCAG T17IGGTITI GTGTrATG Fr WO 00/09525 PCT[US99/17712 EPI-109 159 FIrGCTACTGG AAATCAT7C7 GTGCTGGCTr TGGCTAGGAC AAGGCCAGTG CCTGATAGTA AAAACTGCTr GTITfCAATA TCCT7GCTCT CACTIAAAG TGAATIAAAA M~ACTGCT[ ATATATGCAT CAATACTATC TCTGTAGCTG ACACCATGCT TGAAACAGTC TCATCACTGC TAATTATGAG CCAMrCAGA AGACAGGTGT GATGAGAG T UACATI'CAA ATCATGTrCT CA~FrATTCrG CTICCGAAT 717CTAATAT GA TCCIA GATTAAGAAT TCTGTCrATT CCATGCTAAT GTCTACAAAG TITATCAGC ACATCACAGT TAAAAAAAAA CAGCAAAGAA TrCA'rfCTTA ACACATATGA TCCT=CCCT GGCCAAACAT TAGTrC'IIT AAATGAATCT CAAAGATACG AGGGT7GCTC ATCAAATCTG A TCTATAG TTAAAGTGGG TATTGGT1T TITI=CACT GTCCAAGT17 GAAGATGG'T G FCTrAAG AAAGTATAAA TCGAAGGATC TCAAGCTTAC CTTCACAAAC TGGGATGC TGTGTCCACT GCCCT7GAGT GGTGCArCA ACCTGGGCTG GTCCCTGCAA CATGAAGCCT TCCTCACAGG TGAAG FrGCA GGATGATrG AAGGTGAACT CTCCAGCAGG GGAATGGCTG CACCTCACAG AGCCAT'TCTG AGGCTGGCGG ACGGCCCTGC ATGTCACAGC TGTAACAAAT ATACGCATFG ATATTAGCAC GGCCrAGAAT TAGC'ITGCCC ATITCCAGTA TGGGTTGAGA GAAAGAATGT TCACAGTAAG TCTCCATGTG GAACAACTCT ACCTTTACAC GTTGGCTTCT CGTTGTCCCA A F1CCCAGAT GAGGTACACT GAAGGCTCTG GGCTCCCATT AGTrCAAATC CTTC1CACA GTCAAATGTA CAGGUrGTGT TCCATGGGAA GCTrCCAGGG I=rGGAAAC ATrCCACGAA CCCATrGGCT GGAT'11GTCA CAGCATCACA CTCAACCACT GAGGA=IrA AAGAGCACCA TGAAT=AC AGAAGAATGA TCTITCACT TCCTrATrGAG CTGGTGCCT AACAGAGTGA GGAAGCTGCC TrCAAAGGGT AGATCCCAAA GTCCTATGTC AATrC'rrAGG GACATGCACA GCCAGAATAA AAGCTITAT TCITITCAT GGATATTCTA TGTITCTGA 1TrCCAC1T GCCTATGCTG AGTGGTCTCT AATCTATGTr ATCKITJACG TGAGGTAAAA MT=AAAAAA AATAGATrCC AGAT-rAGGAG TTATGACTAG TACTGACATA CGTAGGCTAT TCA'I1A1TT TAGCCCATCA GAGCCTGAAG AACTGATF= TCT1TrIrG GCCTCTGGTT CAGAAAGATA AAATTAAGAG AGAAAAAGAG ATACTAAGAC TGCTTGACTA TCATGGTCTr AAG'ITAGTCC CATGGCT7GG AAAAG7FAAA CAGGGAAACA AGATGAGAAA TCCATTGAGA TrrAGAGC MIATrGM~ TATGGTCTCC =TACAAATC ACCAGAGCC7 CAGAAACACC CA T7CAAGC ATAGAATAAA AAAACCTCTC TCAACCCAAG CAGGTACTGG G'I1GGCAATA TACATI'GGCT GAGAGAACAA ATTGTA17AA AAACAAAAAC AAAAAAAAAA CXTCCCTGA AG=IGAAA ATGTAAGTrG AATCAAAAAA CAGAAGCAAT GAGGGATGAG TT1ACAGAACG TrCTGTGCAT TCTCAGAGGG A ITTACCA F7 GCAGGCTGGA ATAGGAGCAC TCCATTCTCC AGAGGACATA CACTGCATGG TCTCCATGCT GCTTGGCAGG TAACCCCTAT CACAGCTGAT AGAGCAGGAA GAATrGTAGC TGAAGTTTCC CAGTGGGTGA CTGCAAACCA GGC1TCCATG CTCAGGGGAT TCCAGGGCTG TACAGTrCAC AACTGAAAAA GAAACCCAAA TCAGflCTGC TCATCTCTCA CCT=AACAG ATAAGAACAC TGGAAACTAG AACTACAGTT TGG'TITr TTrAGT T-rAAAAATr ATAAAATT7C TAATGGAA'T TGTAAAATTG ACTGTAA'FrC TACCCC'Ir C=rIAT7CA AGAAAATGCT GATCCATAAC AACAACAACA AAAAAGCAGT GATGACAACC ATAAAAAAGA AATATrGAGT GATATGGGGA GAGTAGTGTA ATrGTGMrA CCTCAAAACT GTrCAAAT7A TATGAACAAA CACAGCAAAC TITAGGTACCA CAACAAA'Tr CTTGTTrAC17 TTCTCACAAC TGCTAAAAAT ACTACAGTAA GCTTCCAACC AGGATGAGAA CCATrCACAA AGCTATAM~ CAAA'TrTAAG TACTAGAATA CATTACAAAT 'IMAAAACCC TAATGCTrGCA CTGTCTACTA TAGTAGCCAC TATCTGTGTG GCTACTCAAA TTrAAACT'rG AA'rrCGTrGA AATCAAATAA CA'TTrAAAAT TCAGTTCCTC AGTGTCACCA GCCACATT7C AAGTACTCAA TAACCACATG TGGCTCATAG GTACACACTG GAAAACACAG CTATGGAACA MTCCATTAT CACAAAAGCT CTACTGCACA ACGCTGTGCT AAGGAATCT7 GGAGAGAAGC TCATCTAACT CT=~AATGT ACAAA'I=AG GAACTGAGAC CTCA'ITCAT TCAAGTGACT TGCTCCATGC TACACGGCTA GTCATTACAG AGCCAGAGGC CAGAGCATGA ACCAAGATAC CCTGGACTCT GTAACTCACT CA'ITrCTACT GCAACGTC= G'rrACCACCT AGATGAGGTG AGTACATGTT CCTCGCAGGG ACACAGAATT ACAGM~AT7 GAATGTGTCC TGTGTGCCAG GCACCATGTA ACCATGAGCC TATGAAGTTC ACAC]TAI7AT TATCCTCATTr TrACAATGAG AAAACTGACA TAGAGAGTTA AACTATCTTG TCAAGGTGCC AAAATAAATA ACTGGTGAAT CTAGGACTCA AACCCAGCAG GGTCTGAC= CATAGTCTCA GCTCACGATC ACCATATGAC ACCATCTGCA CCAGGGAAGG GAAGGCATGC AGACCTGACT CTAATGCCAG CTAGGACGTG AGATGGTGCT ACCATCTCAA GTGAAGAAAG AGGCAAGAAC CAGAMIACT TrGCTCACAC TrGAGTCCAC TGAAGCCAGG GTCACACTrG CAAGTGTAAT TAUTGATGGT CTCTACACAT TCACCGTGGC CACTGCAGGA TGTATTGGTA CAGGCAGCTA CGGAAAATAC AAAGCATGAT GAGGAGGACT AT7ACTGTGC TFATACTGAG TGCCTTGAT MTAGAATCA ACAGTGTGCA ACAGAGACAT CAGCAGTCCT ACAGAGTGCC ATAGACTFA ACTGAAGTGT 7rrACAAAGT TCCAAATCTG AGTTCAGGC CCACCTATCC TAAACCTTGA TGCTAATGTA TAGCTGTGGC TGGCACCTAC CGTAGAAAAT TrACrTCT7C ACAAACTCTG AAGACAGTTC CCCTACCACA AATAAACAAG TAATTAAAAT ATGTAUTGTG TGTGTGCAT7 TIATATGTA AAGAACTACA TMT7GCCTA CAGTATI7AT ATATAtITA TATATATACA TACACACATA TATGTGTGTA TATGTGTGTA TGTATATATA TAAAATGTAT ATAAATGCTG TAGGCTATAT ATATATACAC ACACACATAT ATGTGTGTGT GTATATATGT GTGTGTGTGT ATATATATAC ATATCCACAT ATT=GCCC ACAT-FCACAC AAAACAGCAA AAGAGAGAAA C1TAGCAGT TAAACAGAAT CTI=GGAAC ATAAAATGAC CACAATAGAG AGCAGTTTI GCATGCTGTA AATrGCCAA GATGCCCACA CACTGAAACT ACCTCCCACT GCTGCCGCAA ACTCCCTACC TGTGTAGCAT AGGGCAAGCT TCTTCTTGCT GCACCTCTCA TCATTCCACA TGCCCACATC 'TI=CTCTC TrGATGTAGA TCTCCACGCA GTCCTCATCT TITGCCTAT TGTTGGGT7C ACCTGGAGCC CAGTrCTrGG CTr=TCTGT CAGAGG'I=C TGGG ITCCTA CCCAGACCCA CACATTGT7G ACTI=CTGA T7CCAATCCA GTAATAACTT GGTGAATAGC TCAATATGGA G'I1rAGGTAC TCAATCTCTT CTIG1TIG AATrGCAACC AGGTGTGTGT ACCFIGCTG ACAATAAGCA CTGGCCTCAT CATAAGTCAT AGCT]rCCGTG GAGGTG77GT AAGACCAGGC TCCACTCTCT7 TrAATGAGAA GCACTrAGTGG GAGAAAAAGA AAAGAAATGG TAGAG17GG TACTGTTGTG G'TAACTCT GACAACTGTG C7rIT7FG TCTTATIT= GGCAATGThT GTGACATGGC CCAGAC=IT CrCATUI I I CAAAAGTAAG AAGTACGTAT GAAGAAACAG CGAIT7ATrG MTATCTCF7 TrGTGACTGC CACCCACTAG GTACCTrATC CACACTCACT CACAACATTA TAGTATACCC A=IrGTAGT AGAATAATAA TCAGAATAAC TAAGC=rAT TGAGCACTTA GTATGCACCA AGAAGCACTG TATGAGGTAC 717CCATGAA CCATGCTAT-r GAATCCTCAC AATGCATCTG GGAAATAGGT CATTATGATC CACACTTAC ACTrAAGGAA AGGGAGACAC CAAGAGGTAA AGTAAATGAC CCCAAGCCCA GGGAAGAACA CATFGCAGGT AGAGGTCAAG GATGCTGCCA GATATCCTGT GCAGGACAGC CCCAGACAAG CAAGGATATT TCAGTCTGAA ATATCTATAG TGCGAGAATG AGAAAT=TG GTCTAATGGC ACTGACTTAC CCAAAGTGAG AGCTGAGAGA AACTGTGAAG CAATCATGAC 7rCAAGAGTT CTFICACCC AAAGGTIT7AG GC=GAAATA ='~CCTGGG GAGATAAAAC ACAAAATGAA T[AAAGAAGG AAATCGTGGG TAGCTAGTTA CATrAT7C7A CCATGATG IT TAAGGCAGCA TCCTAAGATT TrGGGCAAAG GACACTAGTG CAATAATCT TATTTCAGAG TI17AATCAAA TAAATAAACA AA=PAAGA CTICATTAT TrAGGTCAAA GAGAAAAGAC AGGTITAGC TACAATACAA TAAGAGCTTG TACAGATGTG GTn=Al7A GAAGGC='T TGCATATCTG TGM~CATGG CCCGAGGCTG CCCTrATAAA GCG'TrCTGCA CYrACCG717 TGGGAAGCAG TrGrrCAAAC ACAGGATCTC TCAGGTGGGT ATCACTGCTG CCTCTGTCTC AGGTCAGTAT AGGAGFI=G ATGTGAAGTC AGCCAAGAAC AGCTGAACAC TACrrCGGCr GAGGCCCTI TATAGGAGGG A TGC'CCT GTGAATAATA GGAGGATATr GTCCACATCC AGTAAAGAGG AAATCCCCAA TGGCATCCAA AAAC'=CCC GGGAATATCC ACGATGCTTA AAATTACAAT GATGTCAGAA ACTCTGTCTC rTGAAGCTAC TTCACC1TG TCCATGCCTr TATATCGTAT ATGCANIT= AT7AATATGA CAAAAATGCA TGATI=AA TTATAATAAC ATAAAGTCTA TGTCT=AAA AAGTrGTAAA ACTIGCT7G 'TrAGTAGTGT CTCTCATGTA GT'TGTGGTAG TAATrAGAAT T7CAGAAACA GAAGGAAACC AAGAATAGGT TITGTCATCCA TAGTCTACTA CCTrCAA'IM CTCA'rrCATA GCrGTGGATA ACCAATCACT ACTCATIT TCT7CCITI TCACCTGCCA AT7CAACATA TPAACATGC ACTGTCTCAC AGAGGAATGA CTCACAAGGT AGATATrAAT CT17CAGATFI7 TGCACGGCAG TFATGCCTAA A ITAAAATAT TATCTAAAAA TAATATCTAA CACTCAAATG GTTAAAATAA TGCC=ATI7 TAAAAAAAGA AAAATGGGAA ATAGATAMT WO 00/09525 PCTIUS99/1 7712 EPI-109 160 ACATCTGGGA AAGTITFCATG G=TGflCAG TGAAAAAAAT AAAAAGGAGG CCAGGCACAG TGGCTCACGC CTGTAATCCC ACCACITGG GAGGCCGAGG CAGGCGGATC ACCTGAGGCC GGGAGTFrCAA GACCAGCCTG ACCAACATGG AGAAACGCCA TCTCTACTAA AAATACAAAA FrAGCTGGGC ATGGTGGCGC ATGCCTGTAA TCCCAGCTAC TCGGGAGGCT GAGGCAGGAG AATCGCTrGA ACCCGGGAAG TGGAGGTrGC AGTGAGCCAA GATCACGCCA GTGCACTCCA GCCrGGGAAA CGAGTGAAAC TCTGTCTrAA AAAAAAAAAA AAAAAAAGAA AAGAAAAGAA AAAAAATAAA ACGGAAAACT ATATATATAT KITJAAT-FGG TCAAAA=II G=TAAAATTr ITFGAAATGT TAATGTGCAA AGAATAAAAA T7CT7CCACA ATGTrAACAG TGACTAACTC TGGATGGCAG GAI=GGGAT AA TITATA TCCTrCATlA TrAT1TCAG GA'II1AAAG TITIrfCAA TTCCCl= TICACCTT ATAGTAACAA GAATACAG~r TAAAGAAACT TGTCTCTAGG CCAGGCATGA TGGCTCATGC CTGTAATCCC AGCAC1TGG GAGGCTGAGG TGGGTGGATC ACCTGAGGTC AGGAGTrCCA GACCAGCGTG GCCAATATGG TGAAACCCTG TCTCTACTAA AAATACAAA ATTAGCCGGG GTGTAGTGGC GCATGCCTGT AATCCCAGCT ACTGGGGAGC CTGATGCAAG AGAATCGCT' GAACCCAGGA GGCAGAGGfl GCAGTGAGCT GAAATCACAC CATrGCACTC CAGCCTGGGC GACAGAGCAA GACTCCATCT CAAAAAAAAA GAAAAAAAGA AAAAGAAAAG AAAAGAAA'I7 TGTIT7CCAAA TGCAACAGAA GGAGATGTAT GTGGTATCCT ATATTCCTGC T=~CA=I~ GACA'Trr= CTGGGTGATT GTATACAT7C CCCATCTCTG CATCTrACCC TATCTAAATG ATGGTAACAG TAAATGGGGA TCATI=AAT TFCCATATTC TGTAGGTTI CAGAGCTCAA GTCAAGCTAA TAT7CTATAT CrACAGCCTr TCAAAATAGG AGGTCTATCT AAAAATGTAC TGTCAGCAGA CCTGAACGAG TAGTGGTAAA AGCCrCGM~ T7CTCI=AC FrGTrAGCAC TGGTCTI7CT GTGTrCATAA AGATGTCAAG ACCCAAAAAA AAAACAAGAA AAGAGAAGAA AAATrCCAAA AAAGACAACT GATrAGAAAA AAATAAMTA ATTAACGAAT 'I1AATlCAAC CCCTATCAAA AAGCATAGAA MTrTCCCT CCACCTTACC ACTCTCTTrAC ATGATCCAGA TACTc3ACATT A~rCCAA77C TITATCCCAC TACTTAGC TCAATGTGGT TG77GCTTCA ATAAAflCAG AAGAGTAATC ACTCATATAG TGMIATI1A GA=I1AGGG CAGAATGTCA AGTTGGGTrA ATACATTATC TGTATGTATT TrKATfAA TAAAGTATGA ATACATAATC TGCTA7FTF AAAAAGCATG GTCAAATGTA TAGAGTAGCC AAATCTTfAAA AAACAAM~A TCrrCGATAT CAATAAAGTA CCTAATAATT ATA'GCTAA TAGAAATTAG TCGTTAACAT CCCTAGATAA CTAACTIAT TATTGCGAAT =FTCATAAC TAAGTIATA GTIT7ATCTCT TCCCCI 1 AAAATTAGTr CAAAGATATC TAAAAATAGC CCCAGTGGTG ATGAAGTITC TATITACT7 ACATATATAT GTCCTGGACC CCCAATrATA ATCTCTAACA =TATrGAGT G=~ACTATG TGCCAGGCCA TA 1TcTGAGC A=rGTATG TI7CACCTA Fr GATTATTCAA TCCGTACAAC AGCCrATGAA ATAGGTACTC CTATrATCCC CAI=rACAG ATGAGGAAAT TGAGAATCTG GGGATITAT CTCATrCAAA AGCACAGAGC TAAGGGTrGA AACCAGGCAG TTGATATCCA GAGCCCACTC C=TACCTGC TACTCCAAAC CATGA=TCT FIGTTG'T7A TGCCCCGAGA TTCCTTC TACCCAAG'T TCCTGTACTC rrcrrCCCT CITCTrCCTG AGACATCCTr GACCATCACA GCTCrCCACT GAGATAACTG TGTCCTGGGT TCTGAGACAT GGGGGCTGGA AGGGACCCCA GGGACAGTGA GCAGTAGGGA GAGGATGCAG TGAGAACAGA CCCFGGATCC CCGGTGCATA GGCAGGGAGA AAGTGGACAA AGGAAAAAAC AAGCAAGGCA GGTGGAGCCA TGCCTAGGTA AAG1TTGATCC CTAAGCCACA GT7CCCAGAA G7rCCTFGATT CAAAAGCAAA =ITCTCTAA GGTCAAAGGG CAAACTGA7T ATTCTAAATT CTAAACTGAT TA TI'CTAAA TTGAGAAAGC 'ITCAGGGAGA GATCCCAATA TTCGAAGGAT AAGAGAAATG AGGAGTGGAA GAGATAGGTG AGTAACAGTA ACTrAAATGT AGACTATATA TAATATATAA TATATGTAGA GTATATATAT ATAA FTACAA TATA'ITATAT ATGTGGAATA TATATATrAT T7ATATATAT TTATATATr TATATATATA GATAITITIA TATITATAT ATAAATATAG ATATITAT AT1TATATA TAAATATAGA TAYT=TATA TATATTATAT ATAAATATAT GTAAAATACT GTGAAAGAAG AATAGAATCT TGAGACCTCA AATTCACTAT GCCAAAGGGA AAGTTAAGCT TGGGAAATGA GTCATGCAAA AACTGCCTC CTITGTTCC CAAATACCTG TAA'IMCACA TGC17AC=- ATC=ATATA AAATGTAGAT GTACTrGAGCA TGAGATCCAT GCATAAMrC CCTCTAGTCC Cr'm A CATGTAAAGT GTAGACTCAC TGAGTGTrAC AGAGCCTTGC CACAATGTAA ACACrGTCI7 CATrGCCAAC CCATCTTCG =A=ITCT TCCCCTCCTG CrrGcCr= CCCCTrCTAAA GATGGAAGTr CCCAAAACTC TCI=GGAAA AAGCGCAGGT CACAGATCCT ACAGTGA IT GTGTTTI TACCTrGGGAC AAAATAAACC TCTAATCTGT TGAGATATGC TTCAGTJ7ACT TITGGM~A CAATATGTAC ATGTATGTAT ATAATT17ATA TGTATATAAT ATATGTACTr GTITAACCA GAGGTATGTr ATTCAAAATC CIT7CATCCT TACAATTACC TGCATTCTCC CACAGTAMT TCTGTGTCCC TGCCCCCGAG GTTGTCACTG CAAATCAGGT ACATGGATAC TGGGAGCTGA TGGGCTCCCC TCTGGCTACC TGGGCTGCTG AAGGGGCCAT AGACAGACCC AG=1ICCTC TCGTGGAGAG GCCCTGGGCC AGCGCTGCGT GGGAGTGGGA TTACAACCAG ACTATAGCTT CTTCACCTGC TITPCCTAT CAGGATITCA TAAGAGGCAA T~rTGGTT 'IMGAGGGTG GGGGCAAATC AGGGGGAGTr GAAGAGGAAA TrGGGTAAGA TIGAATAGT TGGGCATGTT GAATATTATG AATATCATCT CCCTCrrCAA ATAATCCAAA ATATACCCCC AAGAAACAGG CTGATrAGAG GTGCTrCAAG GCTCCACTGA ATCTCCCAAG CTCTGAAGAT GTAGCTAGCT GTTACCGGAT TGCCGGT=r CAAGCCTCGC CTCACATGGA CCCTCTTGGC AGTICTCGC ATGGGGGAAG CATCCGCTAC ATAGATGGGA ATGAAAAGAG GAAAGAAGAC GGTGCAAACT CAGGCACACC CCGGTGTCTG CCACCAGTGC TA'TrFAATCT CTGAGGTGTC ACCCTTCCTG GC1TAl7GT CTCT7CCTGG AAGTCTCITG TCCTCTCCTC CACACCC'= AATCAGGCAT CAAAGACTT AACCAG=II GCTGTGTGCC CAGGCCCACT CA'ITCTCAcT TIATGGCAA AGGGAGTGGG AGACAGAGAG ATAGCCAGAA AGAAGAGAIT GGGGACCCCA AGACAAATGT TAGAATI=A ACCAAGGCCA CCCTGTGGAC AGGAGATTAT TGGGMIAGT GGAAAGCAGC ACTGGCCACA ACCACACGTG GCAAAAGCAT CTATCGAGGA GTGAAGT7AT A=TGGTGAA TGTGACCGGG AAGCAGGGGC AGTGGTGTCC TCCTGCCTTC CTGAGGCACT CTG'TCCCTr ACCTCTGCGA AGGCTA=T TACCCCTGAG TGCT7AGT~r TGAAAGC=T AGUrCCCTCT CTCCCATAAA AAAGCTCrAC TCTGC2AACA TCTAAGT7AC CTITGCAGAG TCITAGGTAG AGGGAGGAAA TCCCAATAAA GAT1TCCACCC TATCTGCAAA ATACAAACAT GGTA==XT GCATrCCCAA AATrGTGAAA GAAAATGTGT ATCACCACAG TAGAGAATGG CATTITGT T7GATCAAAA CCTAAATATA TTTGATGAAA ATGTGTCTGG ITCTAAG'I7I A'ITCCCAGA AAGCCATGT7 TACTCACTTG GAAMrATAG ACATCTrATA ATATCTGAGT CGAGTAGGAG CTCCGGGCTC TACCTCACTC =IrCTCCCA CACCCAGGGG GAAGTGTAGG GTrCTCAGAC TI1AGAATAA AGAGGAATCA CCTGGACAAC TCACCTAAAA TGCACATCITT CAGGTCTCAT ACTCAGAGGC TCTGACTCAA CAGGTCTGGG TGGCGCCCAA GAAM~GGGC '1TAAATGAG TATCTCAGAT GA TCTAATA CAGAATGTGT AAGATGACCA GATCCTATCA CACTTAGATG TATTGGCCTA GGGCCACCTA A='1GGAGAA AATGTrAGTA AGACCCCGTG GrTGGTGCTC AGCTATAGGT ACCAGAAMr TGATCAAAAT TrACTATCAT TGTGACACTI7 CTCITCGGAA CrGGAAGGCC AGAACCCCAC TTGTAAAGTG CTGGGAAAAT ACAAGGAAAA 7ITTAGGGTGA GTAGCATTT GAATTCTrAC ACATGGAAAG TAAATGTATA AGAATTCTTA CCAATAAAAA AAAAGCAAGA GAGAATAGCT GCTAAAGAAT TAACACAAAT ATGTATATAT TAG~rAT7CT CTITT7CTCCT CrGATrCCAG AGGACT=GT AAflCCACTA A'T=CTTG AGCTTCCAGG ATGATCrGAG AC=GAA= T rCATGTGCT TITGCTTCC TA~rrGGCAG CATCTTATCT TGAAGITrCC GC1TCTGCr TGGGGACCTA AAAACTAACT AATGGGAAT7 TCTTCAAAAT GAGCAAACTC TGGTGAATrC CCAAAGCGGA AGAAACAAGT GAGGATCGGG CTGGTFAATT AAGAGAA=T TTCCTGAATG TAGCCAGACT G'ITGCCGAC TG'TrGTTAAC ATGAGGGAAG AAATACCCCT GGATITAGA AGAGCCC=7 G=TTr'TC MTGGCCA17 TGTGCTGCTT G=rGTAAG TCAGAAAMr CCTGAAGGAC TA'ITAT7AGC '1TGTTCTCA CGTCAGAAAA CTrCTGCTCT GGCCACT1T AAACATATAA CTTGGATI= ACTGTATrAG AAAATGTAAC AA ITACAGAC AGCACTAAAA GGACACCAAA GGGCAAAGAA AATGGGTAAC T1i i ii iiCT TCCCCAAATC TAAAATAGGT GATITGGAG AAGTAGGAGA AAAACCTGGA TITCTAGAT CTCI=AGAG CTCAACAACT GATATAG'I1A A'TITATGTAAG TC'=GATAT F7GGAAATGA TrGGATTAAC CGGATAACAA TGAATA'IMA AATACAGTGA TI'GGCCAGG AGCAGTGGCT CATGCCTGTA ATCCCAGCAT 'FrGGGGAGGC TGAGGCGGGT GGATCACCTA AGGCCGGGAG TTCCAGACCA GCCTGGCCAA CATGGTGAAA CCCCATCTCT ACTAAAAATA CAAAA'ITAGC CAGGCGTGGT WO 00/09525 PCT/US99/17712 EPI-109 161 GGTGCAAGAC TGTAATCCCA GCAACTCGGG AGGCTGAGGC AGGAGAA TrG CTfGAACCCG GGAGGCAGAG G ITGCAGTGA GCCAAGATCA CGCCATrGCA CTCCAGCCTG GGCAACAAGA GCGAAATTCC ATCTCAATAA ATAAATAAAT AAATACAGTG A'IMAACACA AGAGATTTCT AnI7CACACT AATGAGCTCT GTCACTGGGG CAAGCTrC'T TGCCTCATrA AGTCTCAGAT TrCCCGAGAG CTrTA'rr TATACCAAGA GTGCTTACT ACCGTCTCTG CTAGCTGTGA CATAATATGA CAAAAGGTAT AAATATGGGA AAAGGCACTA ATITATATCA AAGCGT~TTI' CGn=ThCCT TGCTGTGAAG TfTTAGCTA ATAATTCATA AGAATATACC ATAMTAGAG TGTTTACTAT GCATGGGCCT GGCACTTCAC ATACATrGCT TCTTACAAAT TIACAAAGT GAAAGGTAGA TATTAATCTC A FITATGGA GGACAAGATA GAGATCTGGA GAGGTTACAT AACT7GCCAG TGTTI=CA GTrFAATAAAT GGTAGGGTGG AGATTCAATC TGTGTrACTC TAAAGTCCGT GTCCTTITA flGGCTCCAT GCGTACTCAG A'IMAAATCT CAGCAGGGAA GTAAACCTTA G'IITACAT GAGAAAATGT TACAGCAGCC 11rCTCGGC'1 CCIIACCCC CATCCCAGTr TCACGAGCT AGTGCCTTAG ATCGGGTTCC 'IMAGAAGCA GACCTCGAAA TAAGGATGTG GGTGCCAGTC ATTrATrGAA AAGATGATCC CAAGAAAGCC TAGTAGGAGA GTGAGGAAGT GAGATGGGGA AAGGAAGAAA CTCCACAAGA AGTGTGTrAA TAAGCAGG77 ACCGCTr3TGG GCAGCCATGG GGCTCAGCTG CACTAACAAA CrCTGTCTAG TACAGAAAAC CTCAGGGTCT CCCCAAGGAG GGGCAAGAAG TCTGCCTAGG GTATATATCC GCCAACTCAG TCACTGGCTG AGAGCTGATC CTGGGAGGGC ATGGTTAA'rr CCTCTGCACT TTCAAGTGGA TTCCTGTGGT CAGAAAAAGC CCTrCTACAAT GAATrCCAGA TGCfl7GTAT7 TAAATCTGAC ATGATCTrGAA TGCTGTGTTG GGACAGGGTG GGCGTTATrA G=[rCTGTC ATTAC]TGTAA CAGA17ACTA CAAACCTGAT GGCTGCAAAC AACACATATT TATrATGTCA TAG'I7GT3T GGGTCAGAAG TACAGGTTrAG CTCAACTAGT TI1CTCTGCTC TAGGTICAC ATTGCCAATA TCAAGGTGTC ATCCAGTrGG GCTCTTCTTG GGAGGCTTGG GGATGAATCC ACTTCAAGC TCA117CAGAT TG'ITGGCAGA ATCCAGT7CC 'FrGTGGTTGC AGGACCAAGG TCCCTGTrGC =TGCTGGCT G~rGGCCAGG AGTCAT~T= AGCrAGA GACTACCTGT ACTCTCTGAC TCGTGTCTCC ACTTCACC= TCAAACCAGC AGCGGCTAGT CGAGTCCCTC TCTrCAAATG TCTCCAACTG TGCCTCACC TCA'TrCTCC TCTGTGTACC ATGTCTGCCT CTACTGCT7G TAAGGGCTCA TGGGATTACA TTGGATFFAT TCAATCCAGG ATAATCTCCA TA=rrAAGG CTAGCTGACT AGTGATCTI'A ATFCCATCTA CAAAGTCCCT TCCAATAGTA C7GTAT7AGT CCATr=CAT GCTACTGATA AAGACATACC CAAGACTGGG CAATrCACAA AAGAAAGAGG T7AATFTAGA 71rACAG~rC CACATGGCTG GGGAAGCCTC ACAATCATGG CAGAAGTCAA GGAAGAGCAA GTCATGTCTT ACATAGATGG CAGCAGGCAA AGAGAGAGAG CITGTGCAGG GAACTCCTCT 1T1AAAACC ATCAGATCTC ATAATACTIA 'I1CACTrATCA CAAGAACAGC ATGGGAAAGT CTrGCCCCCA TGATTCAATT ACTCCCACCA GGTCCCTCCC ACAACATGCA GGAATrCAAG ATGAGATTTG TGTGGGGACA CAGCCAAACC ATATCAAGTA CCTAGATTCA TGTrGATTrA AACAACCAGG GAGCAGAAAT ='1CAGGAGT GGGGGGCATC 'FMAGAATF7C TGCCCACCAA GGCTGGGCGC GGTGGCTCAC ACCTGTAATC CCAGCACTI GGGAGGCCAA GGTGGGTGGA TCATGAGGTC AAGAGATCGA GACCACCCTG GCCATGGTGA AACCCCATFI CTACTAAAAA TACAAAAATT AGCCAGGTAT GGTGGTGGGC ACCrGTAGTC CCAGCTACTC AGGAGGCTGA GGTAGGAGAA TCAC=GAAC CCAGGAAGCG GAGGTrGCAG TGAGCCAAGA TrGCGCCGCT GCACTCCAGC CTGGGAGACA GAGCAAGACT GTCTCAAAAA AAAAGAATTC TGCCCATCAT AGTAGGCTGT CCTACAGAGA CATAACCCAG GAAITAGGTG AATGGCTAAC CTAAATrAGC ACTGTGATGT GTTICTGAC TTGGTCCTrA TAGCTCCTCT GCTrAGATGT GGAACTAATC CATGAATGCA AGGG 1TGTC TAGAGTI=A AGTGGGAGTT AAATATCCAA AGTACAGGAG ATATI'ATGGG TGCCTCATCC ATGTCCCMr GGCAITFATC F17cTTGGAT AACCCAACTC TA'FrAG=r~ TATATCTCAC YrGTrCCTAT ACTCTGTGAA CTGATGTCCC ATAAATAGAC AM CATMT GCCAGTCTC TTGAACAATA ATrACGA'rrA TTAATCTAGC AGTTATCATT AATTGGCCAC TTCACA'FrAG ACACAGCACT TAGGACrAA GAATACCATG TCAThrGATC ATCATAATAT GGTCAGGAAT TAAGTATrGC TATCCAAATT 17ACAAAGAA GGCACTGAGG GTrAGAGT AAATAA=IG C77AAGATGT CATAGCCTGT AAGTGACAAA ACTAGGACTC AAATACAGGT CCATCTGACT CCAAAGTCTA TGTTC717GGC TACCACACTG CCTCTCCTAC AAGTGACCTG TGG7ITACT ACTATATrTCA CACTCTACTA A=TIACCAT CTCCCATGAG TCTGTCTAGA GGAGGGCACA CACAGCACAG AAAACACATG AATGCAAAAT AAGGAAGGGC CTA=TACTA CACAGAGCCA TTrAATACC TGATGTITGC TCTAATCCAG 'r=ACTATr AATrAGT-rGC TGGTGCCCAA GTITTACTG AGAAATGGGG ATAATTTGG AAGTCATAAT GATGCCTCT TCTCATAGGG TA'TITAm1 GTFGTTGTAT CTCCAGGCCC CAACACAGCC TGGCrI=AG TAAATGATCA AAAATACCTG TTGAATGAAT AAATGGAGTC ACCTGAAACA TGTITAAACAT TTGT7CATGT GTCCTrAATCG TGGATTCAG GATAGTAAGC ATCCTAAAAG GAAAGCATGC ACACTGT7CT TGCTACATTA MTTCTCACA ATATAAAAAA AGAAAAGCAT CTGAAAAAAG CTGCCAGCCG CTGTGTCTCC TAATATCAAA CTGAGCACAG ATATGGAGAA GCTAAGGGAG AGGGATGATG GGCCATGCCT CTAACCTCAT CATGGCAAAA GTCCTGGGGG TCAGACCCGA GGAGAGCAGG AAGTGTCTI TGAGGGATAC AMICCACAG TGGAAATAAT GAGA=TAAA TAAATA FIAT ATACACAGIT CAACTGTF= TATGTGTAAA GGTAGTAGGT TTICACAGTA AGGAAGCACT TCTTI1TFF= rTrG'I=GAG ACAGAGTCTC GCTCTGTCTC CCAGCCTGGA GTACAGTGGT GCTATCTCGG CTCACTGCAA TCTCTGCCTC CTGGAT'TCAA GTGATTCTCC TGCCTCAGCC TCCCGAGTAG CTGGGACAAC AGGTGTGTGC CATrACACCT GGCTAArI= TGTAITITA GCAGAGATGC GOTCACCA TGTTGGCCAG GCTGATCTCG AACTCCTGAC CTCAGGTGTr CTGCCCGCCT CTGCCTCCCA ATGTGCTGGG A ITACAGGCA TGAGCCACTG CACTCACCAA GCACTTCTAC TGATAGCATr TACAAACCCT TC=AGAATA 'ITAAAAATr CTAAGAGAAG AGTAAA17GA GC=FCCCAA CTAATACTAG GAGGTrATAA C=TCATACC AAAACTGGAC AATGCTGCA CAAAAGAAGG AAGCCAATGA GGCCACCTAG AAGGAAGACT GGGCATTGGG CCCAGTGAGT CCTGGAAACC TCATCTGTGC CAGCCACCCC GGCATGGCCT GTATGAGTGG ATGAGGGTGA CTTGTCCACA GACAATAGCC ATCTAGCTGT GATAAAGGAG TCAAGGTAGT CAGCTGCATC TC1TCACCT GTIGCCAAT GTTACACAGG TrGAAAAGCT AAGGTTATG TAAAGCAAGC ATCAAAGATG ATGAAATGAT CAACCTGACA ATGAGTACTA TGCTGCATrG TCCAGAAAGG AACTGTGGAA GATITGGGC TGAAMTCAA AACAGAA'I7r CCTCACTCTC TGGATGTTGG C'ITA=~GGC C'=GATGTr CAGAGGTGGT GCCITGTGT TGTTGAACAA TGTrGATI= GGAGAGAAAA CAGAGTTGAA AAACCCACAA GTCA 1TCCCT GGGGAGTA Fr ACCGGAATAC AGAGGATAAT TTCAGCAAGC CAGCAAGGCC TCATCTCTGC TrCTAATAGA TAGGAAGAAA GGAAGAGAGG AACAATACTT 7ITAAGAAG CTCAGC1T7A TCGC=rATC TCATAGAAAG ATGCCTCCAG TCTGTCTGGC TAAAGGTAAT TGGCATGGGA AAGTCI=AT CrGTGATrCT AACAAGTGGA ATG'ITCCCT TCATTAAGAG AGCCTrGTCT GGC'ITGGGGA AATGAAACAC nI7CTCCGAT ATGAGTGGGC TGTAACCCCT GCTACTAAAT ACTCAGAAGA AATAAGGCGG IT7GTGGAGCA GTCAGGAATG AGTCACTTGC CTCCCTGGAA TATTCAGAAA ACTGAATCAA AAGTACATI'C T7CTGGGTI TCTTAGTCTA ATAGACTAAG GGTCTCTACT 7rG~rAAAT7 TCTGGGAAAC AGCATAGAAT GGGAGAAAAA ACTGGTCACT GTAGTCATGC AAATCTGCAA AACAAACAAA AAAGTCTGGG TATGCTGCT AACTAGCTAT GTGACCTTAA GCAAGGTATT AACTCTCTCT GAAM~CAGG TrCTTCATCT GTTAAATAGC ATATcTGTAA AATGGGAAT-F A=IICATAT CATAATGCTG TAGCTT]7AAA AAATAAAATA AAATGGATGA GATAATCAGA ATTAAAGAGC CTGGGATATA TAGITAATAT ATAGCAGCAT GTAAAGATCC TGTTAGAAAT GCTAATITA CAGTTAACCA T1IGGAGATG ATCCGCCAAA GCTGCTAGTG TAGAGGCAAC TGAGAATIG CCTGTCC AGAATATGAA TAAATAACTG TCAATGATGT CTCAAGCCTA GAAAAACCTA TCCATCTGGA TGGGTGGGAA ATI7rAGGC TAGTA77GAG AAGCCCA'IT CTGGGAAAT AGGTCCTGGA CTGAGTGAAG GAAAAGAAAC AGTAAAACCC ATGGTAAAGC AGCAAGGCTC TCTAGAGGCT CTGGAGAGGA TGAATTGAAT TCTAGAAGAT GAAGTAGGGA AGACG=IIA CCTTC17GTG AAATGGA7TC AAAGATCAA AGACCTCGG GAATCTCCAA TTGTATAAAT GGCACCATAG CTGTATGTTC CATGGAACAC TA=~CCCAG AGATGCCCAG TGAAAAAAGA ATGCCACAGT CAAATAAGTF[ TGGAAACACT CCATFATGTG GCCACCTCCT TGAAGACTCT AATGCACATr AGCATG'FrAA ACAGTCTGA GAAGTCCTGC AGAGCAGAAA TTG=~CACA TCTGCTAAGC CGGCAG'ITC CCAATATACT TGATTATGGA TAG'II=C CTTACAACAC CATTCTCTGA TATGCICCA ATGACATGAA WO 00/09525 PCT/US99/1 7712 I-109 162 ATAAATATAT ATGCATGAGG 'FrCTrCAMTA GGGCATACTT 'TrFAATAGAA AATATTGAGA ATAATCTAAA TATAAATGCA CAGCATTFAC C1TFCTGCA TAAACTATAT ACAGGCATAC CTFrcGAGATA CTATGGG=T GG3TrCCCACA ATATCTCCAA AACCACATTC GGTI=ATGA CCACTGCCAT AAAACCAGCC ACATGAAT7 ITrG1 ICC CAATGTATAT CAAAGTTACA T=~ACTAT ACCATAGTCTr A'FrATATATA CAATAGCATF1 ATATCTAAAA AACAACGTAA ACACC=AAT TrAAGGCTGT GGCTGG'TrG ATI=CTACC CAGACCACTA AAACF=CTT CATATCAGCA ATAAGGCTGT YrCAC'IMCT TACTA TTT TGTGATAGCA CTI=CCT CCTTCAAGAA 'TrC=rr CTA ITCACAA 'TrGITrGAT ACAAGAGGAC TAGA=IIAG C17ATCTCAG 'ITrAAGGTGT 7rACATrGTT AGCTAAAAAT GCTAATGATC ATCTGAGACT TCAGCAAGTC ATAATCT1T GCTGGTGGAA GGTCTrGCCT CAGTGTTGAT GTCTGCTrGAC TGGGTGGCTI TGGCAATT7C TTAAAGTAAG ACAACAATCA AGMI~GACAT ATCAATrGAC CCTTCCTrGTC ATAAATGATT TFTI17CT CTGTAGCCTG CAATGCTCTT TGATAG3CAT7 TrACCCACAG TAGAAT=TC AAAATTGGAG TCAATCCMT CAAACTCTGG TGCTG=I]A TCAACTAAGT TrATGGAGTA TrAGAAATCC CTTGT-rGTCA TICAACAAT GTrCACACCA TCTCCCCAG GAGTATA'ITC TACCTCAAGA AACCAUIT1C 'IMGCTCATC TATAAGAAGC AGCTCCTCAT CCACTAAAGT M~ATCCTGA GATTGCAACA AFrCAGTrAC ATCTTCAGGC TCTACI1rCTA AtTCTAGTITC T=TGCrGTT TCTATCTCAT U-GTGCTTAC ITCTCCGCT GAAGTC rTGA ACCCCTTrAAA GTCACTrCATG AGGGTrGGAA TCAAC'TCTr ACAAACTCCT GTFTGATG17G ATA=IIGAC CTGCTCCCAT GATTCATGGG TAT7AAT GGCATCTAGA ATGGTGAACG TITCAGAAG GTITCAGTT GGCMIIGCCC GGATCCATCA GACGAATCCC TATCTATGGA AGCTATAGAT TrATAAAATG TATJCTIT TTGTGGGGG CATAGCGTCT CACCCTGTCA CCCAACCTGG AATGCAGTGG CACAGTCATA ACTCACTGAA GACTCAAACT CCTGGGCTCA AGTGAT7=T CCACCT7GGC CTCCCAAAAC ACTGGATTAC AAGCTrGAGC CACTFGTGTCT AGCCCAAAAT GTATATCATA ACTAATGAGG =TGAAAGTC AAAGTGACTC C'F1GATCCAT GGGCTACAGA ATGGACGCTG GGTTACCAGA CATGAAAACA ATACTrCATCT CCTCATACAT CTCC=CAGA GCTrCCTGGGT GAGCAGGCCC ATrGTCAAAT GAGCAGTAGT AT=TGAAAG AAATTIT TCTGAGCAGT AGATCTCCAC AGTGGA=TA AAATAGTCAG TAAACTATGC TGTAAACAGA AGTGCTrGTCA TCCAAGCTCT G7IT=CCAC TGATAGGGCA AAAGCAGAGT AGAMIGGCA TANFI'CTCTA GGGCC117AGG A'mIGGAA TGGCAAATTG AGCATTGGCT TCAACTTIT 11FTI-rIrT TITITI=GAG ACAGAGTC'F GGTCTGTCAC CCAGGCTGGA GTGCAGTGGT GCAATCTCGG CCCACTGCAA GCTCTGCCTC CTAGGTTCAC ACCAT7CTrCC TGCCTCTGCC TCCTGAGTAG CTGGGACTAC AGGCACCCGC CACCATGCCC GGCTAAT=F TTGTArTTA GTACAGACGG GGT17CGCCA TGTTAGCCAG GATGGTCTCG ATCTrCCTGAC CTCGTGATCC ACCCGCCTCG GCCTCCCAAA GTGCTGGGAT TACAGGCGTG AGCCACAGCG CCCAGCCTGT CTrCAACTTA AAGTCGCCAG CTGTGTTAGC CTCTAATAAG AGAGTCTGCC TGTCC=rCA AGCM~GAAG CCAGGCATCA TTCTCTTCTC TAGCTATGAA AATC'7AGAT AGCATCrrCT CCCAATAGGA AGCCATTTT TATGCCCTAA AAATCTGTCG TITTGGTGTAG CCACC=TCAT CATrGAT=r ACCTAGATCC GCTrGGATAAC TTACCACAGT GTCTACATCA TTACTCTGC 'FrCACCTTGC ACT1TATGT TATGGGGATG GCTCC'ITCC TCTAACC TCA TAAACTAACC TCCACTAGCC TCACATTC'I CTTT7ACAGC TTCCTCGCCT CTCTCAGAGT TCACAGAATT GAAGAATG'Fr GGGCC ITGGA 'ITACAC'IMG GTTAAGGGA ATGCITGTGGC TGGM~GAT7 T'rCTATCCAG AACACTAAAA C=TrCAT ATCAGCAATA AGAC~rGT~rC AC1TCTrAC TA I-flTGT GATAGCACT7 TrCCM~CCT TCAAGAA'TM 1rCC=rCTA TTCACAAMT GACCGT~rGA TATGAGAGGC CTAGAT1TA GCCAATCTCA G'IMACACCA TGCCTIT-C ACTAAGC'ITC ATCATITAG CT=ITA I AAAGTAAGAT GTGTGACCCT TCCTI1CAT7 TGAACACTrA CATGATGATG CCTGGC'ITCA AAGCIGAAA GGACAGGCAG ACTCTCT7AT TAGGGGCTAA CACAGCTGGC GACTIT~AAG 'FrGAAGCCAA TGCTCAATTT GCCATTAGAA GCCATTGTAG GG'FrAA'r[AA 717GCCTAAT TFJAATATrA TGGTGTCTCA GGGAATAAGG AGGCCTGAGT AGAGGGAGGG AGATGGGGAA ACAGCCAGTC ATCAGAGCAC ACACAACAT7 TATCAA'ITAA G'ITrATCACC 7rGAGGG1CAC AGGTCATGAT AC=CAAAAC AATTACAATA ATAAAATAAA AAATCATTGA TCGCAGATCA CCATAACAGA TATAATGATA ATGAAAAA F7 TGAAGTATTG TGAGAATrAC CAAAACGTGA CACACAGACA CAAAGTGAGC ACATGTCAT7 GGAAAAGTGG TGCTGATAGA CTA=TCAT GCAGGGTrGC CACAAATACT CAATCTGTAA AAAATTCAAT TATCTACATA GTACCATAAA AACAAGGTAT ACCTGTI1AT ATAATCAAGA CCAACAGAAC CCTAGAGAAA ATAGCTCACT CCCTAGCTCG GAGACA FrCT AACCAACATA CA=TACCTT TCTTIMGCT GTGTACAGAA T7CAAATCCC TGTCTrCAGCA AAATTGCAAA GTATCAAATG TCATGTCCAT CTAATACTCA AAACTGCAAA TGTTAAGTCT TGTAAGCCCA GAGACCACTG TATATACAAG TGTTGCTrATA AGCATTAGrr =~CTCCAAA GAAAATAGTC CACTT7GGTAG AAACAAACAA AAAGAAAAAA AAAGAAAGAA AAAACATFIT TrACAAGAAG A17CAGTCTC 'FrACCTACAT AAGCAAAAAT ATGAGATGTr CTCTrATCAT T1TCCATCT ATCTATAAT CMTGGTGC T GA=~AGACA CTCA=IICC 'FTTGTACG TGACCATGTA AAAGTrCAAG TCAAGAAAAA CT1G=T1GA CA'T~rGT1T GCTGAGTGAT GGGTCCC TAA AAGAAA T1G GCMIGCMT TGAAAAG'FrC AGCATGATAT TGTGTGAAT7 rI-TCATGGCT AATGAT1TF AGAACAG~rG TGATGTGTT7 AGGTGTITA AGAATATGAA GCATrCAGTG GMTAAGT7G GTTG7rATAA AATGAAAGAA TATGAAGGAA AGCCT17CT17G TCTAGAACA CACTrGATrCA CAAATAAGCA GC=CTCTCA AAATGTrGTA ATrACAAAAA TTCCAAGGCA AATATAATAA ACTCCTTGTC GGTGCTATGT CTAGAAACIT AACAGCCCCA AAGAAAGTCC TGACAAGGCA AAAAATATAT ATATATATAC AAATrGTGGA AGCAGGGTGT TGAAAGAAGA ATAAAGACTA TATAAGGACA AACTG1AA AAGGGAGGGT ATCC11?GAAA GCTTGACACT TGACTrCT=T GACGAGGCTG AGGGAAAACA CTCAGTITCA TAGA FTGCTG GTACGGATGT AAAATAGTGA CATCCCTATA GAGAGGAATT TGGCAATATC TAGCAAAAGT GCT7ATGCAT TTATFTCMTG ACCTAGTAAT CCCGCIT7CTA GGATTAGTGG TGAAGATACA CCTCAACAAT AAAAATATAT ATACATrAGG TTA1TAGYFA TGGTI17AATI7 TI7AATAGCA AAATATIAA AACAACCTAC ATGAACAAAT AGGAGACTTA CTGAATAAAC TATGGTATAT CTGTACAATA AAGTGCAATr CACTTATGTT GTrAAMTGT TCCAAAAATC CAGAGCCAAA GAGTAMTGT TATGCTCTCT T17AGTATAAG AAAGGGGAAA TAAGATATGT GTGCATCTGT TTATTITGT GAAAATAAGT ACAGAAAGGA TAAGTAAGAA ACTAGTAAAA CTAGT~rATCT CCTAGTG17A GTAGAAATAG AATGAAAGTG AATTAGGCTI CMIGAGTAT ATGTITATAT ATAG=ITGA CTITGAATTI ATGTI1TATGT TACATAGTC AAAAATATAA A'FrAATCAAC AGAAATAACA AAAAAAGAAG AAATCACAAG CM~AAAA'Tr TAATACAAAC AGAAATAATr GAATCTAACA GTATATCAAA GTGATAACGT AAACTCAGAA GAAAAAAACA TAATCCAACA TACCAGTGGA ACACAATATr CTAACTrGTAT ACATTCAGTG GTrATAGTCT AAGGACAAGA AAAA~rGCAA AAATATCTIG AACM~AGCT TGTAGGA'F17 'rArGGTAG CAATACTAAT GTACTAA'TrC TGAAA'FrAAT GTTCGTGTAT TATAGAATrG AGTAAATGAA TAAATATGTT GATGTTA7TG GGAACTAAAA T1TATCATTCT GGGAGTAGAG AAATATAAAT ATGGACTrGG CAAATGAAAC AAAGACCTGC AGAGAGATAA CCATATAAAC TCAFATTI AAAAATTATA AGTGTCCTAG CTCTGTTACT GAAAAGGCCT AGA17CAATC FTATCTrGAT AGACAGGAGG GCACCCCTIT CTCAGAACAT GG'ITCCAAA TGCCATrCTC CATTAAAAGG AACAAGGTCT TCT7GGAGAA AAGACTGA'IT CTAGGTCTGG ATTAGGTAAA GTACAACGT7 AGTCTGGAAT TCTTGCTGA ATCAGAAGTA AGAAAGTGCT CAAAAACATG GGAACATGTC ACAAACACAC GTGAGGCAAC TTGAATCCTC ACTGGCCATA MTAGGACAA TCGAGCATCA AAAAAAAAAA AAATGITGAG AATAATGGAT TCTAACACT-F AAAACAAAAA ATAATCCATA GCCCACAGAA GGGGAAGAGA GGGGGAGCTC TrA'Tr7ACAG ATGAATATCA AATAGCAAAG ACAGAAGAAA TGACAGAATI' AGAGAAACAT CATI=GCAA AACACCACTG TAATAATCAA TITCAGGCAAG TATTArrFAAT GGATGTAITA CTATrTGCGTA AAACCAGTTG GGGAACAGGA TATrCATACA GTCTGAAGGT GTCACCCTAA ACATAAC ITA TrACAAGTGG AAAATGGTGC C'FMACAATG AAGAAATCTA GCAGAAACCA TCTEAATCTA GTGATCAAAC FrAGTATCAC CAATAATGGA TCATACTrGAG TCATGTGTCT CCTAATATGA TGCACCAGGA AGGATGCAAC GTCATGAACG 'ITGTATrCTI TrGTATrCAA CAGACCACCC AGGGTAAAGG CAGCMTCTC ACTTACTAAT CAGAAT7GTT GGT1TAATT CA1ThGGAT 1AAGA F17 CTTACM~CT TGTCAGCTCA GAAAMTrr TAAGATGAT7 'IMATCT1T ATrCAATACT TTAGC=GGA GAACCATTCA GAGTrCrAA WO 00/09525 PCT/US99/17712 EPI-109 163 CTCATTGTAT TGCCAAAAAT AGAAAACAGC ATGGTTTCTr TrGAAAATGT CTAAC'I=AA AG'I1ACT]GT GTGTGTCACT CAGAUTCACA TAGC'TTF GCCTAGTAAT GTAGTATCAT GTGGCAAGGC TATAAAAATG TrT7ACAATCT rrrA1TAAT ATGACTCTrG AGAG=T7f CTAAGGAAAT AATTGAATAG TAACAAAACA CTATTAACAC AAAGCATAGC AA 1TGA 1T GGGCAACCAA ACACTGGAAA CAACCTAAAT GTCCATrACA GGAATCAT ATGAAGCAAA CACTAAAATA TI1ATrGTGA AGATTATGAG AACATAGAAG ACAG FTATGA GAGTAAMTr GAAAACCTGA ACACAAAACT TACATATACT CCAATTGTAA C1TATAAAAA ATACGTGCAT ATAAGGATAA AACAGTACAA ACAAAAAAAT AGTTGCG'rA GATrGGTAGA ATTATGGCrC CTITGCTGT CTTAA=flT TCCT1TACA TrIGATACA TrAT1]AAT TTAATITA AAA TCAAAA GAATITGCCA CTCATC'=G CCAC=CAAG GAAAAAAGAA ATGTGTrCGA TFA FTCTGT7 =TAGTATAG =mGGCAAT TrCCTCACGT GTAAAAAGAG AATACTrATIA ATAATTFCAG TATCTATAAG ACAATATAAA ATTAAAGAAT CTAGCCCAGT AACTGGTACA TGGAACGTAA TTAATAAATC ATTATGGACT TrI=CTCA CACCCAAGTA GGGAGGAATC AGTGGTCCCC TAGAGGCCCA GTGTAGAGGT GGCAGCACCA ATCCCTAGGG GAGAAGATCT TGGTGATGAT AA'r7CCTGAG CAGACAGTTA GCTGAGAATT CAAGAGCAGA AAAGTAAGAA AGAAACAACT TC'ITGCTAAC ACCTICCAC CCACGTrTCC CTGT7CTGT7 GTACTCTGCT TACCC'TCA TGGATGGAGG CAGAGGAAAG AGAACCAAGT TrGGTCT-rAG TCA FTCACTA TG'rrG'IAA TCTGCCTCC ATCTICTrA TCAGTTCAAA TTAGAATGTA GACCTcIAA'rT TAAATCCCCG TTCTGTCAGT TATAATGTGA CCCTAGACAA AACACA FFCT CTGAACCTCA GAGAACA'FrC TrCAITr7GTA GAATGGGAAG AT7AATCTAT AT7CCACTG GATGGCAAGT C'I!ATAAA CI=ATAACC TAAACATGTG TGAGTTGCTA GTATCATTAT GTTGGTAAAG T-fATTCTGAG ATATGATAAC AGAACTGTTr TGTCTAACTC CACTAGCATG GTrCAGG'IM AGAGAGTGTG GAA'FrAAAAG G=TIATCCT CAAATATGAC 'FrAAATCCGA 1T1TCTCAT CCAC'=CCT CCACAAACAA ATCCTCAGGA AATGACAAAC TACATGGT TAAACATCAG =FTG'IMAG TCTTGACAT CCACATGGTT AAATCATACA YI1GAAAACT GCTTATATI7 GTGTrGTCTA TGTCTAAATT GAAAAGACTr ATTGAGGAAT AGAAGACTAC ACATITICA GCAAACACTG CACG=IIGC AGAATICCC CAGGCACCAG TCTCCAGGAA TTFATTGGCT ACTAACAATA CTAAGATATG GATGAATGAG GAAATCAAAA TGGAGATC'F GCAAG=ITG TGAGAATGGG TGAATGGTCC AAATGAAGAG ATAAGT7GTG AAATATrAGT ACAAGTAAAA AT~TACA ATGAAAGACA TI=GTCAAT AGCTATGAGA A T=ACCAT TGACCCAGAA AT7CCNTTC TTT=CAGA AATACCCACG TAGGTATACA TATAAAAAGT TATTCA'FAC AGTATCG'I7r TrCATAGGAA AAAGTTIAA AAATCAGAAG CTATCTAAAC TATGGTATAT CTAGGTCATA GAAATCAAAT GACTAAAAAT GT1rAATATAA GCATATGTI TT-AAATrAAC 'FrGGCTrGGG TCTrCAGCAA AATTGGC'I1C FrAACAT7GC ACTCCAGAGT TAGACTTACC CACTCAGTCA CTTATCATGC AGGAGCAGAC TCCTAATACC ACATATCATA GAGCAGAGTA GGACACAGGT TCTCTGCAGG CAGGCAAATC CCAAAGAGAA GGGAGGAAAG GGCTGAGACA CTGCATGGTC AATrCTCT GAACTCTGCA ATGTACGGAG GTGGACAGTG TCCACAAAGA TrGCTCCCCT GGACCCACCA TCATAATAAC ACAACGG=~ TG=F~GMP T7GTfIT=GT 'TrrGACAC GGAG=IFGC T=IGTTGTC CAGGCTrGGAG TGCAATGGTG TGATCTCGAC TCACCACAAC CTCCA=~CC TGGGTrCAAG TGATTCTCCT GCCTCAGCCT CCTGAGTGGA TGGGATTACA GGCATGCACC ACCATGCCCA GCTAA1T=G TATFITAGT AGAGACGAGG 'I=CTCCACG F7GGCCAGGC TGGTCTCAAA CTCTrAACCT CAGGTGATCC ACCCGT=TG GCCTCCCAAA GTGCTGCGAT TACAGGTGTG AGCCACCGCG CCCAGCCCAC AATGGCCTI TGMTACATC TCTAGTGCAG CACTCAnI1C ATGTTCT1C AAGAAGAATA CATA'I=CAT C7TI1ATIT TATACAGCAA FrAGCACAGT GCCTGGCATA AGGAAAATGA TCATTAAAAG CTGGGTGAAA AACCTAATAA AGCTACTGAG GATAGGAACT GCAGACCAGC ATGGAAAGAA AACTATGAGC CAGATAT7GA CATCATCCTG AAAGGCAGAA GATTrAGTAT AGGCAAGAAG TATGCTI=G GAATATAGAA AATCTGGATT ATGATAAGAA AAGAATCATA T1TGTC'ITAT CrT7ACCTACT CACTTCTCAG TTCCACATGT 'FrCTGAGGCT GTI7GTCCTr AC=T~ CTGTITATC CACTCITCT GTrTTAGA T7GGATCAI7 CCTATrGAGC TGACATCAAG TTAACTGACC =IFATITG TCCAAACTGC TG'ITAAATGC ATCCAGTGAA 'T=AAC17 TATATAGTAT ATC=1TAGT CCTAGAAMr CCACATGAGT T"=hAAGTT TCCATITCTC TGCTGAGATC TCCTATITGT TCATrCA'ITA TGACCATATT ITCTCTACA T7ATTGAGCA TAATrATAAC AGCTCTrCTA AAATrCTTGT CTGCACAT7C TAACACCTGA ATTA FrCTGG GGTCAGTCTC TGT'TACATTG CCTTATrACA AAAACAGTAT AAGTCACATTF GCCT7GTC T-rAATATGCA AAATGATTI TGAT7GCAGA CTAGACAT7 TGAATTAAAC ATTATAGAGA TrCTGGATTC TCGAGAGAGT ATTGACTTGT 7IT=CCATC AGGCAGGTAA =TGACTGGA CTCAAACTCC AAACTCTAGG TCCTCTGTAA TGGGCAACTG CAGTAATCTT TG'ITrAGTTC 71TTAAGACTT ATTGGCCAGG CACGGGGGCT CATGCCTGCA ATCCCAGCAC TGTGGGAGGC CAAGGTGGGA GGATCACCTG AGGTCAGGAG TCGAGACCA GCCTGGCCCA CATGGTGAAA CCCTGCCTCT ACTAAAAATA CAAAAATTAG CCGGGTGTGG TGGTGGGCGC CTGTAGTCCC AGCTACTCAG AAGGCTAAGG CAGAAGAATC AC17GAACCT GGAAGGCAGA GG'FrGCAGTG AGCCGAGATT GTGCCACTAT ACTCCAGCCT GGGTGACAAA AGCGAGACTC CCTCTCAAAA AAAAATIAT TGGCACTGCT TGGCATCTGC TATGAATACA TGAAGTTCAT GGGTCAGCTA TAGATCTGGG CACGTTATAC ACAGAATTrG GGTCTCCCP TCrCTGGATr TCTCCTITC TGGACT TITCTCATIT CCAGCAGCTG TGGTrGCCCT AAACTCGGTC CTCTGMTCT 'FrACGGCAGT AAGAT1TGGG AACTITAGG TITACCTGC CTCTrCAGACA AAATAAAAAA TAATITCAT CFIGATGCTA CTCC1TCTT CCAGATGTAG ACACCTCTCT AA'ITCCAGT TGCTITAT TGCTCTCCAG AGTCTAAAGA TTATCATrGT 'rCTGTGGG AGAGTTGG3TC TGATAAAAAC TACTCCCCCA AAACTGGAAG CTGGAAG=~ GTAA'ITATGA ATAGACI=G AGTAGTATrC T7=TGGAA AAGGATI=A ACTACTCCCT ATGTAC~rCT flATTTCCTG 7IflCTCAT CCGTAATCTT 'T7ATITCA TACTT7CCTAA GTCAGACAAT MTCCTACTr GAAGATTCAG TGACTGCTAT CAAATGACCC CCATATTACT AAATACAATA TCCCCAACTG CA'1ATAAA AAGAAAAT1T ACTGM~AT-f AGTAAACAAT GTrGTAGAAT AGTAAAATAT TGCTGGGCTr TGGAGCCAGA TAATCAAGGT TAGAATCCCA GATTCTAACT TACTAGCTGG TGTATTAGTC CI=CTCATG CrGCTAATAA AGACATACCC CAGACTGGGA GACTGGGTAA T'ITATGAAGA AAAGAGGMh AA F7GACTCA CAGTrFCAGCA TGGCTGGGGA GGCCITAGGA AAC=ACAGT CATGGTGGCA GCAAGGAGAA GT7CCAAGCA AAGAGGGAAA AGCCCCTIAT AAAACCATCT GATcTTATGA c3AACTCACTC ACTATCACGA GAACAGCATG AGGGTAACTG CCCTCACGTT TAA'TTACC= CCACCAG ITC CCCCCCATGA CACATGGGGA FTATGAAAGC TATAATTCAA GATGAGAT17 GGGTGGAGAA ATAGCCAAAC CATATAATTC CACCCCTGGC CCCTCTCAAA TCTCATGTCC TCACA TrCA AAACTCAATC ATGCCCTCCC AACTGTCCCC CAAGGTCTrA ACTCATTCCA GCATrAAGTC AAAAATCCAA GTrCAAAGTC TCATCTGAGA CAAGGCAAGT CCCTrCTGCC TATGAGCCTA TAAAATCAAA AGCATGTTAG TTAC=CCTA GATACAGTGG GGGTACAGGC GT7GGGTAAA TACACTGATr CCAAATGGGA GAAAT~TGCCA AAACAAAAGA GT7ACAGACC CCATGCAAGT CCAAAACCCA ATAGGGCAGT CATTAACA F7 AAAGTrCCAA AATGATCTCC TIT7GACT7CA TGTCTCACAT CCAGGTCACA CTGATGCAAG AGGTGGGCTT CCAATGGCCT TGGGCAGCTC TGCCCCTGTG GC1TGCAGG GTATAGCCTG CrrGMI GC1r=CAC AGGCTGACAT TGAGTGTCTG TGGCTI=CC ATGAGTATGG TGCAAGCTGT TGGTGGAM~ ACCAT'rCTGG GGTCTGGGCC AGGTGCAGTG GCTCATGCCT GTAATCCCAG CACTIGGGA GGCTGAGGTG GGGGATCACA AGGTCAGGAG ATCGAGACCA TCCTGGCTAA CACGGTAAAA CCCAGTCTCT G=~AAAAAA TACAAAAAAT TAGCCAGGCG TGGTGGTGGG TGCCTGTAGT CCCAGATACT TGGGAGGCTG AGGCAGGAGA ATGGCGTGAA CCCAGGAGGT GGAGCrTGCA GCGAGCTGAG A ITGTGCCAC TGCACTCCAG CCTGGGCGAC AGAGCAAGAC TCCATCAAAA AAAAAAACAA AAAAACCATT CTGGGGTCTG GAGAATGGTA GCCCTTACAG CACCACCAGG CAGTGCCCCA GTGGGGACTC TGTGTGGGGG UCT7GACCCC ACATI7rCCCT TCTGCACGGC CCTAGTAGAG GT7CTCCATG AGGGTTCTAC CCCTGCAGCA AACTCTGCC TGGACATCCA GGCATrCCA TACATCCTCG GAAATCTAAG CCGCGGAGGT TCCCAAACT CAAT'TCTTGA CTCCTGTGCA CCCACAGGCT CAATACCACA TGTAAGCCAC CAATGCTTGG TCAGGGCT7G AACCCTCTGA AGCAATGGCC TGAGCTGTAC G'ITGACACCT TITAGCCTAG ACATCTAGGA CACAGGGCAC CATGACCCGA AGCT7CATAA AGTGGGAGGG CCTTGGGACT AGCTGAGGAA WO 00/09525 PCT/US99/17712 EPI-109 164 ACCATFI=C CATCCTAGGC CTCCAGGCCT GTGATGGGAA GGGCAGCCAT GAAGGTGCCT GACATGCCCT GGAGACGTrT TCCCCArrGT CTTGGTAACT AACATTCAGC TCCGTGTGCA GCACCAACTT AC=ATGCAA ATI1CTGTCA CTGGflTGAA ITCTCCCCA GAAAACAGGA TrrrCT= CTATTGCATC ATCATGCTGC AAAT=rCAA ACTIT1ATGC TATGCFrCCT GTrGAAGACT FGCGG=rA GAAA'ITT CCCCCAGATA CCCAAAATTA TCTCrCTCAA GTTCAAAGflr CCACAGATAT CTAGGGGACA AAATGTTGCC AGTCTCTTG CATAGCAAGA GTGACC'=A CTCCAGT7CC CAACAAGTT CTCATCTCCA TATGAGACCA TCTCAGCTrG GACTTAGTTG TCCATGTTAC TATCAACATr 77GGTCAAAG CCATrCAACA AGTCTCTATG AAGTI1CAAA =TCCCCATG T1TCCrGTC T7CTAATAGC CCTCCAAATT TTCCAACCT CTGTCTGTTA CCCAGTrCTA AAGTCACTTC TACATITIG GGTATCITA CAGCAGTGGC ACTCCCCATG GTACTAMT= ACTGTATTAG TCTGTrCTCA TGCTGCTAAT AAAGACTI'AC TCGAGACTGG GTAATrTATA AAGAACAGAG GTTCAACTGG CTCACAGTFC AGCATGGCTG GGAGGCCTCA GGAAACTTAC AAACATGGTG GCAGCAAAGA GAAGTrCCAA GCAAAGAGGG AAAAGCCCCT TATAAAACCA TCAGATCTTG TGAGAATTCA CTATCATGAA AATAGCATGA GGGTAACTGC CCCCATGA Ff AA'I1ACCTC CCACAGGGTC CCTCCCATGA CAGGTGGGGA TrATGGGAAC TACAATCAA GATGAGA'Tr GGGTGGGGAC ACAGCCATAC CATGCCAGCT AGAGAGCCT AAGAAAG1TCA CCTAATCTCC ACAAATAAAA GGMITCCTAT TTGFCAACA AAAATAATGA CACCCCFIT ATGGGArT'1C TGTGAGGACA AATGATAACT AACATAGCCT TGCATAGTGT CTGGCACAAA ATAGCrACTC AAAAAATAAT AGAAACAACA TTAAAAAAT GTAGACITA TIT1TAGAG =F'TATGTAC AAAGCAAAAT TGAG3CAGAAT GTACAGAGAG TFrCCGTATA GCACTCCCTA CCCCCAAGCA CAGATAGCCT CCCCCAGTAT CAGCATCCCG CACCAGAGTG GTACATI1AT TATAACTGAT GAATCTATAT TGACGTGTCA T1TCATCCA AAATCCATAG 'FrTATATrAG GGATGCCTCT TGGTGTTGTA C=TCTATGG GTrGACAA ATGTATAATG ACATGTATTC ACCATTACAG TATCATAAAG AATAGTIT7CA CTGTCCTAAA AATC'TIGAT CT~C1CCTA TTCATCACTC CCTCCCCATr AATCCCTGAC AACTACTGCT AA=IICCTG TCTCCATTGT YTGTCI=r CCTGAATGTC ATATAG = A AATATACAGT ATGTAGGATT TrCAAACTGG 'I=AMrCAC 'rTAGTAATAT GCATTTGATG rrCTrCCATA TCTITCAAA GCTrCATAGT TCAATATTrA TAGAATTGAA TAATA7TCCA TTGTCTGGAT GTACTACAGT TI7ATGTA'ITC ATITCACCTAT CAAAGAACAC CTGGTI7GCT TCCAAGT=C AACAATCATG AGTAAAGCTG CTATAAACAT CTATGTACAT GTITrTIGT GAATTGAACA =fTCAGCT TITAGCTCC ATFCCTAGGA GTGCAATrTGC TGGATTGTAT GATAAGGGTA TGTTAGTGT TGTAAGAAAC TGCCACGCTC FI'CCTAACTG GATGTA~rGT TFrGCAUT~c CACCAGCAAT GAAAGAG'FFC CTGTrGCTCC ACATACTCAC CAGCA FITGG TGTCGTCAAT GTITGAGCA ATAGCAITI GATCTAACTT TCCTAGGTA TFFC7rEGA AGGAAATAAT ATGACAGATA ATAGAGAAAG GATATACGAG GACAGTI'CTG TCC'=AIT ATAGTCCATC A'FIAATGAA GGACTrGTC CACA=TGGT AITITAACT CTGATCCTCC TCTCCCATGA ACTCTGACAA TCTCCTAAAT CCCTGTGCT GGCACACATG GTTGTGTATC AGGCCCCCTG TGGTCTGTCT GAAGCATGGC TTITIITF 7TIII n-M=TFGAG ACGGAGTCTC GCTCTGTCGC CCAGGCTGGA GTGCAGTGGC GCGATCTCGG CTCACTGCAA GCTCCGCCTC CCGGGFFCAC GCCATrCTCC TGCCTCAGCC TCCCGAGTAG CTGGGACTAC AGGCGCCCGC CACCACGCCT GGCTAATII TrGTATIT AGTAGAGGCG GGGITTCACT GTG'FIAGCCA GGATGGTCTC GATC1rCCFGA CCT7GTGATC CGCCCGCCTC TGCCTCCCAA AGTGCTGGGA TTACAGGCGT GAGCCACCGC GCCCGGCCT TTIT=l ITTTTI =GAGATGG AGTCTGTCAC TCTGTCACCC AGGCTGGTGC AGTGATGCAA TCTrGGCTCA CTACAACCTC CATC'=CAG GTlCAAGTGA TTCTGCCACC TCAGCCTCCC AAGTACCTGG GATI'ACAGGT GCCCGCCACC ACACCCAGCT A'TTITGT ATITIAGTA GAGACGTAGT T7CACCATGT TGGCCAGGCT GGTCTCATFC CTGAC=TGA GTGATCCACC TGCCTGGCC TCCCAAAGTG CTGGGATFAC AGGCATGGGT CATCACATGT GGCCTGAAGC ATGACTGT17G ='TAATCAT ATGAAATACT GCTCTGTATT7 GTI7ATCrATr TGAAATGCCA CACCTCCTGA GCTAAATFGC AAGCITIAT GGAGCACAAA CCATA TTTAT ATATArTAGC ATGATACCAT GACACATATC AAAAGCTGTT ATATATFGT7 ACGTGAATFG ATFCTICrC AGTI'AAGAGG ACCTCTGTAG TAGCAC'TC ATACCGTTAA TITCAMT TGTGCCCAGC CCCTACTCTG TGAAAAATGA AATGAATCCT G~rATCAT' CCCTCCCAGG CCTITCTCC FFGTGGACAA TGTGTGGCTC AAGAGAAAAT TCAGTCAGTA AA=T'rCA GTGCACAAAC TC'TATCAC CTCTCACTGT TCTCAAGTGA GATAGAACAG AACATCCATC CAGTGTcITA CAAATrGTCT GGTATATAGT AGGCACTCAA TAAATG=~T TI7GAATAAAT GCATACATGA ATCCTAITCC TATATATAGT ATGGTAGACA GATCATFGAT ACCCAAAGAT GCCCAAATGC TGATCCCCAG AA=FGTGAA TATGTFACAT 'FFCATGTCAA AAGGGA=rr GCTAATGTGA FFAAGGATFFC AGACCCTGG ATFGTAAGAT TATCCCGGAT TAACCAGGGC CAATCTAATC ACATGAGACC TTAAAAAAGC AGAAAACA1T TCCCAGCTGG GTTAGAGAGA GATGAGACAG AGTAAAAAGG AAAGAGATrC AGGGCATGAA AATGACTCTA CCCACTGT7G CTGGCTTGA AGATAGAGGA ACTAGGCCAC AAAACAAGGA GTATGAGTGG CCTAAGAAA TAGGAAAAAG CCCTCATCTG ACAGCCAGCT AGAAAGCAGT CCTCTGACCA CAAGAAATTG GATTCTGCCA ACCACTCAAA TGAGCAAGGA AATGGATrCT CCCCTAGAAC CTCCAGAAAG GAACACAGCT CTGTAATGCC T-rGAITIAG CCAGGTGAGA CCTGTTCAG AC1T=GACC TATGGAAATA TAAGATAATA AAG'FTIAT[ GTATGCTGCT AAAT7GCGG TAG=T'A CTGAAGCAAT GGAAAGCCAA TACAGACAGA ATATACAGAG AGAAAGAGAA TGAGTFCTI CCTGATAA'IT TGTAAATATfl TGGGTCTrCA CTGGACAAGC TFCACAGAGG ATrCACrGGT TCCCTAGCAA ACCAGCATGT CCAGTCCTGC AGCCTCCCI TCI7AGGCCC AGCATATGTC AGCTGTGTGC ATAGAAAAAT CAAAGCAGGA CCCTGAGTAG TITGGAAAGAA AAGATGGTTG GAAATGGGTT GCACTTCAAG TGAGGAAACA AGAGGTAGGA GACCGGCATC T=IICTCAT ATGTCCCAGG CTGACTCTTG TGAGTTGTI7 TCCCT7GGAG GCTATCGATG ACAGTCACAG TAACCTGATG GAACCTGGAT CATGATGAAA GAAGTAAGTG TCAATGGCTC CGAC=CCAA GGACTCTGAT GTCCCACAGC ACTAGCTAAA CAAAGCCAGT TGGAAATGAG CTTAAATGGG GAATTCCTG AATATATITCC CTATTGTI'AG GAAGCCAGGT TGGCC GCCTACAATT ATGCCAAGCA GTCACACTAT AGAGTCCCTA GGGACATGAT ATTAAGTGAT TC'TrTAACA CAAACAACTT AATAATCAI17 TATACTAATA GCAAAACGGC CAACGGCTGA TATrCCA=T GAAGTAGAAT TGGCTATCCA ACTGGAAGAG AAGACAGGAA GACGTGATCT CCAGGGAGCC ACTAAAAGGA TFGGCACCTG CCTCTGGAT7 CCCCrrrCC TTATATFACC TCTCAGCACT GGCAGGCCTF7 TA TTCAGGA TACAGTTCA CAAGTATTAT GTCACGTCTC TGAGAA FFAT GTFGGTAGAT A ITGCTCCT CTGGCCAGAA AGACCTAGTT TGGAGTCTGG AGTCATGAAG GTGACATACA TGTAGCTAGT GACATAAGTG TAGCTAGTAA AAATAGTGAG TAATGGCCCT GAAATTCTAT TGAATGCCCA AAGTGCTrGAC CAGGAACAAG CATGCTrCTAG =TATCTrCAC AAGGAACTFG ACAAITICr TCAAAAATCC TAGTAGCTAA GATITFCTTAG TAACAAAGCC ACTAAGGCAC AAT-rATGAT7 AACTGACCC TrAGGTGACT I=AAGGACT AITCTATAAA ATA ITACAAC TAATAGTGGA TCCAAGCCAG CACACTCTGC TATATAAGAT TAAT7GACAG TGTCCACACT GGTAAAATAA G1rT1FCAT AAATACATrA GAATrCATfT GCACITCTA CACAGCCCCA AGTCCAGAAC TFCCCCAGA ATAGGTCTAT GTITGCAAT CTGCrACTCC ATACAGAGAT F1'GAGTI'CAC TTGGCAATFr AGTGCTGCT ATATGTGACC AGTFAGTCTG T]TA=TAT CTATGCCITA AACATTACTA TACTTACTAA CTCCAAGATG CCrGGTCTCA AC'TrGACAAA AATACCCCAA GTrGGGAAAT CCITATGTGA ATATGTAGAT AGTCACAA'IT GCTGGTTGAT GATGATCTGT CIf=CCTGT A=~GAGAAA ATGGAGATAA AATGGACCAA TCCAAATAAT GGATTAAACA TGGGAATAGG TGAGAGAGAG AGAGGAATAC ATGGTGGCTC TCAGTGTCTG GCTIAGGCAG TAAACA=11 CGTrAATAAA GACGGAAAAT AAAAAAGGAA TAATTGGTGT CTAGGGGAAA ATAATGAGCT CAAGITIAA CACTCTGAGT TCCCGGATGT GAGACATCCA GGCGCAITrA TCCAAGAGGC AGTI7GGAAGC AACGITCCGG AGGIAGGAG AGAGGCATGA CCAAAAGCTG GTGGGACTGT GAAAAGGTAT GGCCAI7CTG GAAAACTGI17 TGGCAG'TFC T[AGAAAAFF AAACATGTAC TAACAACCCA GCAATrGTAC T=TGAGCAT TrGTCCCAGA TAAATGAAAA AAAAAAAAAG CA'TTlTI ACACAAAAAC ATATACATGA AAGTI'CATAG AAGTGTTrA1T CATAAAAAAC TGGAAAAAAC TGAGATGTCT ITAFT7GAGTG AATGC'ITAGG CAAACGGTGG TCTATCCATA CAATGGAATT ATGC'ITAGCA ATAAAGAGAA AAGAACTAT7 GATACATGCA ATAACACAGA TGAATCTCAA AGGAATTAAT WO 00/09525 PCT/US99/17712 EPI-109 165 GCTGAGTGGG AAAAAAAGCA CATCTCAAAA TGGTATATAC TGTACTAT TATTrACTTA ACATTTTAAA AATAGCAAAA TCATAGAGAT GGAGAACAGA TTAATGGGTA CTGTGTTTTG GGATGGGGAG TGAGAAAAGG GTAAGGTGTA AATATAAAGG GGTAGCACAA AAGAGCCTTG TGGTrGAAGG ATTCTATGTC TTGGTTGTAG TCGTGATTGC AGGAATCTAC ATGTGATAAA ATTGTATGGG TCTACATACG CATACACACA AGAGCATATA AAACTGGTGA CATGTGAAGA AGCTCCGCAC ATTGTGCCAA CATCAGTATC CTAGTTTCAA TATCAGACTA CAGTTATACA AAACATTGTC ATTGAGGGAA ACTGGGTAAA GGGAACACAG GACATTTGGC ATATATTT GCAATTTCCT GTGAATCCGT AATTATAA AAATAACAGA TATACTACAT ATCAAAAATT TAATGTCATA AAGTTGATGA GTrTACCTAG TGGATAGCTT TGTTAATATC TGCTATAAGA CTACTGAAAA TGACAGTTAT GCAAGTATAA GCTCAGAGAA CTTCCTCCC CCTrCGTAAA TGAAATGAGC AAAAGAAATG AAACAGGAAA GGCAAGCAGT ACTGAAAACA GGGAAGGGCT CTTCCCCATA TAACTATATC TGCGACTTCA ACAGCTATTC ATCCAGAAAC ACAGCCTCTT GCGCTAAGAG GAAACTTTGG ATAACAATAT GTCACTC TCCAAGAGAG AAAATGGATA GATTAATTTT TAAGAAAAAA AAAAAAACCT CACCAATTTC ATGCTGTGGC TTGCACCT AATCCCAGCT ACCTACAAGG CTGAGGTGAG AGGCTrACTT GAGCCCAGGA GTTCAAGGCT GCAATGAGCT ATGATTGATT GTGCTATCGC ACTCCAACCT GGAGTACTAA GCTAAGAGCT AAGAACACAG CTGAGAGCGG AGAAGAAACA AACAAATCTG ACCAATAACC CCCACTCCCC TCA'TTACT GGAGTGAGCT GAGACTGCTG GCAAACATGG CCTTTGACCT AGCCTGAACT GTAGCAAAAG TCATCAGATA 'T1Tl CCACC AATCAACAGA CAGAAGTGGG GAGAAAACAA TCGTAGTTCA TAACTACAAC AAGCAGATAA ACGAAGGCCA TGGTGAGGGA TGGAAGACAT TGTGATATAT CAAAGGCAGG CTCATAAA ACTCAACCCA AATrCCAAAC AAAATATATA ATTGAATATG TATTAATGCC AAAGGAGCTT GAGTGAGCTT TAGCACAAAC CCCGCCCTCC AGCCCCCACC CAAAAAAATC ACTCTGTTCT CTCCCCATTC TGATAGGC ATACTTGCTG ITTTCTCACA GCCAAGGTAC AGAGGGGACT TAGAGGAACT AGAACTCTAA TACACTGCTA GCAGGAATGT AAAATGAAGC ATCTACTTCA GAAAACCATT TTATCAGTMT CTAGAAAGTT AAACATAGAC CCACCATGCA GCCCAGCCAC TCTACTCCTA AGTATTACA CAAGAGAAAT GAAAACGTGT CCCCACACAG TTGTATTTAA AGGTGATGGT TAGCCTTGTG TGTCAACTTG GCTAGGCTAT AATACCCAGT TACTGAATCA AATAGTAATC TAGGTGCATC TGTGAAGGTA TTTTGTAGAT GTGGTTAACA GCTACAATCT GTTGACTTCA AGTAAAGGAG ATTGCTCTrG ATAGTATGGG TGGGCTTCAT CCAATCAATT GAAGGCCTTA AGAGCAAAAA GTAAGGTC CCGGAGAGAA AGAAATTCTG CCTCAAGACT GCAGCCTCAA CTCCTGCCTG AGTTTCCAGT CAGCCAGCCA GCCTAAAGAT TTGCTAGGCA TTATAATCAC ATCAGCTAAT TTCT7AAAAT AAACCTCTT ATATATATTG ATACAATGAA TGGTTATAGC AGCCTATT GTAATAGCCA CAAACTGGAA ACAACCTAAA TGTCCTTCAA TAAGTGAATA CATAAACAAA TTGTGGTATA TCCACAATTT TTACGCAGCA GTAAAAAGGA ATAAATGGTT GAATAAGGAA TAAACACATA ACAAGGATGA ACCTTAAAAC CGTAAGGCTG AATGGAAAAA GTCAGACAAA ACTAATACAT ACTGAATAAT TCCATTTATA TTGAAGTTCT AGAAAATGAG GACTAACCTA TAGTAACAAA AAGCAGAAAA ATTTTGCCCA CTGGTGATGG AGGGGGCGCA GGTATTGTAG AGTATCTGAG AAAGGACAAC TGGATAAAAG GGGGCACAAG AAAACTTTTG AGGGTGATTG ATATGTTCAT TATC=TGTGG CATGGTTCA TAGGTGCATA CATATGTCAA AACATCAAGT TATACACT TAAAATG'TC AGTTTACTGT ATATCTATA TACTTCAGTA GAGAGGAAGG AAGAAAGTGG GCAGGGTGGG GGAGAGGAAA GGAAACGAGG GAGGAAAGGC CCTAATAGGA AGGATTTTGG AGTTTAGATT TTAAAATGAT AAAGGATGTT TGACACTCTA GGCATATGAC GAATATAGGA T7ATGAGTCC ACAAAAACCA CCAGGAAGTC ATGTATGTTT ATACTIITIAA GTGAAGGATC AGTGGATTAT CAACTCCCTA ATGCTGCC TCTCTATGAC TGGCTGCTGT CCTTCTCATC CCAATACTCC TTCCAAAGCC CCTTGCTTAA ATGTAAGCCT TCTCCTCC TCAACACA TCCTGCATTC CGTGACAAAA TAAGTI11CC TTAAACAGAA TGTACAGCAT ATTATTGTA CAATTAAAAA TTITTGGCCA GGTGTGATGA CTCATGCCTG TAATCCCAGC AATTTGGGAG GCCGAGATGT GTGGATTACC TGAGGTCAGG AGTTCGAGAC CAGCCTGGCC AACATGGTGA AACCCTGTCT CTACTAAAAA TACAAAAATT AGCTGAGTGT AGTGTGGCAG GTACCTGTAA TCCCAGCTAC TCAGGAAGCT GAGGCAGGAG AATCGCTTGA ACCTGGGAGG TGGAGGTTGC TGTGAGCAGA GATCAGACTA TTGCATrCTA GGCTAGGAGA CAGAGTGAGA CTCGGTCCCC AAAAAAAAAC ACA-TIT1 TTAATGTTTC CTCCTrGCCT GTAGGAAAAA GGCTCTGACT CCTTAGCCTG GGCATCAGAG CTCTATCTAA ATGGACITTA ACCTGATITi GTGGCACTAA TTCCATTGCA GTACTTGTCC GCTCACTGGC CTGTGCCTCT CTGCCACTAT 'TTGGAATA ATGTCCTCTC TCCATCTTGT TTACTCAACT ATATCCAACC TCTAAGGCTG TGCTCCTACA AAGCCTCCCC TGGCTACTTC AGCCCACAGA GATAITTAAC TGCTCTGCAG TTCAGGACAT TCTTCTGACT CTTAAATCA CATTTACTTA TATATGATCT TGTGATATTT TTGTTGACG TGTMTAC=TT AATTCTTC CATAACCTAT TCATTCAACA AACTCAACAA TTAITATTA AATGCCAAGT TAGAAAAATA TTATTGATTT TATATAGATT ATAGATATGT TTGAAATIT ATTGGCAAT CTGCAAGTAG AAAAATAATT ATAATGTGGT ATATCTGTGA TAGAAGTATT AGTGCAGAGA CCATGGGGAA CATAATCCAG CCTGGAAGTT CAGGAGAGAT ACGTGGAAGA AAGGACGTCA GAGCCT'T CCTACAGGCA TGGAAGAAAC ATTAAAAAAA Al-ITITIT1 TTGAGATGGA GTCTCACTCT GTCTCCCAGC CTAGACTGTG GTGGTGCGAT CTCTGCTCAC TGCAACCTCT GTCTCCCGGG TTCAAGTGAT TCTCCTGCCT CAGCTTCCCA AGTAGCTGGG ATrACAGGTA CCTGCCACAC ATGGATGATA AATATGATCA TATCTTG TCITTCCT CCTCAGTTGT CTTCCCTGAA GAAAGGAATG CCITTTATAG ATGACAAACT CCCATTCTCA AGAACAAGGA -TITGACCA ATTAATTTA ATCAGATGTC TGGCTTGAC CTAGAAACAC AGTCACGAAA CTTGGTGATT AGAGACCAAT TCCCAAACAT GAGCATTTCT TAGGAAACAC AGTAAAGATC TGAGAGACCC AAGAGCAGAA GGGCGAGAAA CCAAAAGCCA TCAGTTTGCA TAGGAAACAC CTTGTTTAGC CTAATCITIT TA11111ATT ACTCTATTAG TCACTACAAC TATTTCTGA TFGCrATGGT GATAGATGGT TTAAAACAAG CCT7CATTAA GAATTGTCAC ACCATGGTCT CAGTCAAAAA CACCAACATT TATTGGTA TTGACAATFA TGGGAATATC CAATTCCAAG AAGACAAGGA GACCTCTGAA CTTTCTAAAT GAAGACTCCA ATCTrCCTGA TCTGATGGGA AGCAGCTrGG CAAGATrACC AACCACCACC ACAGAGAGTG GACTCTAAGC TAAGACTTAA AAGATAAGTA GAAATTATCC AGGTAAAGAT GTGTACAGAG AAGGAAGTAC ATCCAGGGGA AAAGAACAAT ACGTGCAAAA GTACGGAAAT GGTAAAAAGT AATACTACAT AGTCAAAGCC AAGCAGAGTF CAGAAGGGAT CTGGTGGTGA AAAATACGGC TAGAGAAAGC AGCAAGGATT GGCTTCTAAA ACCTATGTAG TATCTTGGAC CTTACCCTAA ATGTAATGAG AAGCTrCTAA AGAATCTTTC ATTTATTCAT TCA7TGAACA AATATTGA GGCTCTGT GAAGAACATC ATTCTAAGTA GTAAAGATAC AGCAGTGAAT AGGACACATA AAATCCTAGA TCTCACAGAA TTGACATTCC AGAGAGGGAA AGGTAGACAA TAAATACATA AACAAATCAT TTAACAAGAT GATITCAGAC AATGGTACGT ACTGTGAAAA AAATGAAACA AGGTAATGGA CAGCGAAAAG GCACTGGAAG GAAGCCTGCT TACC=TTGCA TGGTTAGAAA AGATCTCTCT AAGAAAGAGA CCACATGTGA GCTGCGACCT GAAGGATACC GAGAAGCTAG GTGTGCAAAG ATGTGGGGAC AGAACT111G GACTGAATAG CAAATACAAA TGCCCTTGGG TGCAAGCTTT GCCTGTTCAA GGACCAAAAA GAAGGCCAGT GTGCCTGCAG CATACTAAGC ACAGAGGAAA ACACTGTTAT ATGCTGAGAT TGGAATTATA AGTAGAGCCA GATAATATAG TCTCTTATAG GTCATAATAA GGCAACCAGA TTAT7CCA AGAGGATTrA AAAATCACTG GAGGTTTGC ACTAGGGTGA GAGGTGTGAT TTGTATITF- AAAAGATAAT TCTGGAGAAT TAACTATAAT GAGGTAGGAG TAAACTAAGT TAGGGGCTAT TTCAGTGGCT CAGACAAGAG ATAATGGTAG CTTAGACTAG GATAGTAGTC GTAGAAATAA ATAAAAGTGG CACTCTACTT TGGGGGTAGA GTCTATAATA GGTGGTTT ATGGATCATA TATGAGAGTA AAAAAAAGAA AATAAATTAA TAATGGTTCC TAGGTTGTA CCTGAGCAAC TGAATAAATG GGTGCTGTGA ATTGAGATAA AGGAGATTGA GAATCACAGG CTTTGTTG CAAAT7AATT TTGAGAGGCT TATTAGACAT CCCAGTGGAG ATCAGGTG AGTGGAGCCC ATTGAAAGGT AAGGGACAGG GTCAGGTGTG GTAGGTCAGG CCTGTGATCC CAGGACTTTG GAAGGCCAAG GCAGACAGAT CAGTTGAGCT CAGGAGTTrG AGACCAGCCT GGGCAACATG GGAAAACCCT GTCTCTACAA AATATGCAAA ATATTACCTG GGCATGGTGG CATATGACTG TGGTCCAAGC CACTTGGGGG GCTGAGATGG GAGGATCACT TGAGTACAGG AGGCGGAGGT TGCAGTGAGC CAAGATCTCG CCACTGCAAA CCAGCTTAGG TGACAGAGTG AGAACCTGTC TCAATAAATA AATAAGAAAC GTAAGGGAAA AGGAAATTAA TCTGATCATT WO 00/09525 PCT/US99/17712 EPI-1 09 166 GGCAAATGCA TAGTA'T7AA AGCCAGGGGA GTAGATGAGA TACTCAAAGT AGGTGAAGAT AAGGAGGCAA TGAAGGCCTA GGACTCTGGT GTACATIAG ATGGTITATAA GAGGAATAGA AACTGGCAAA ATAAGTAACA CTGAGCACCC AATGAGGTGG AGAGGAAAGC CAGGAGATGA AGCATCATAG AAGGCAAGAG AAGAAGGGTG TCAAAGAGGC GAGGCAGTCA TCAACTITCTG GGCAGTCAAA TAATATAAGG ACAGAAAAGT GACCAITGGA '1TGGAAATA TGATGAGCAC 1TrTGAGTGGA GTGTrGAGAC AGAAGACCAA TTAGAGTAGA 'ITGAGGAGAT AACGAGAAAT GAGAAAATGT AACCTGCAAG CACAGACAAT T=TGAGAGA CTTTCTGTG AAAGGAAACA GACACAGAGT CTI7AGCATGT CTrGTC=rC TATGGGAAAT GTAAATAG Tr TGAGATCAGG GATAGTATF TA FrCTGCT7 TTGTACCTC TACA'11ACCT AGCATAGAGC TAGCTAATGT GCACTrAAGT ATGTTCTCAA 'Fr'I1ATCGC CTGAATGACT GGATGGGTGA AAGAATGGAT GGATGGATG3G ATGGATGGAT GGAAGGATGG ATGGATGGAT GGAAGACTTC TGAMTGCCA AGAAGAGGAT ACTGGTAGCA GAAATAAAAA CAGCACTGGA GAAAGAAGAG TTT7AGA'IT TA'T=GG TGTCAGTTAG ACAGGAAAGT AAGACAT7AG AAGAGTCCTr AGATAAITT1A TGTAATrGTT CACTTAGGAT YITAAATGT GATCACTGAT ATTGGACATG 'TCCTAGTGA AGCATI=G GTGTI17CACT GGTrGAAGTr AATAACTGTA AAAT-fAT1C CCGTI'CAGGA CAGAAAAACA GAAAACTTGA AGCTCCTATr AGAAAG FrCA AGA'ITCTCTG GGGFTT=AG GATI7rACTGT TCCCAAAACT CTGTCAAGAA CAAGAAAATG ACCTGTATAC TTAACTGGTC TAGGCAACAG TGGAAAGACA AUrCTCAGAG AAGATTGT7 TrAAGAAGAC ACTICCATA GGAATCAAAC AATAGC1TC AGTGACTAAC ATGGTAAGAC ACAGGGTGTr AGCTC'1CC T7CCAACCTC ATGGCTG'ITG TACCT7ACCT TTCGACCCCG TGTTCCTGAA A'rGITrAAAT TCATAAAC7 ACCAAGGACT AACCAGCCTC TGGGGAATTrG CTGTATACTT AGCAAAC'ITA CAATGGACAT ATIATAAGC CATAATGATA ACTGACTAAT AGGAAATACC CTCAACTGAA AATGAGAGAT CATCA'T7GC AAATGAGTTC CCTTGCCCAG GCAACTACTG GGGAAAATGT CATGCAAGCA AAA17AATCT TrGAAATC~T CCT=CCAT ~TGTGTC TTCCITFCC ATAGGCACCA GAAATATCAT GGTGCCTGGA TCTCATCTCT ACAGAAAAAA AAAGTGATT GATAAACTGA TrATAITGT GTCCAAATGT GATTGTATIT7 TCAAAGATAA CCTAAGGGGA GAATGCTGTC TGGCCCAACA GCAGGCTCTC GACTrCA'I= CAGACACTGT GGCCAATGGC TGGGAAACAG GTATGAACAG TAGGMTCTG AGTCCCCTGG AATrATrCCA VnrATGTAGC CACCTCCATG ACAGGAAGCC TCCCTACTCT TA=~CCCAG 'ITGTrCATT CATGGCACCA GGT7GCAGAT TAAAA17GC TCAGTGACCT =FATCTAAT AATGTGTrAC CTTCrrCTCT TAAAAAGTAC AAGGGACAAA TGCTCATGGT ATACTIAG GAGATTGTGG CTCTCTA17A ACAGTATA ITFCAACAAAC AMTTGAG CATITATATG TGCATCATGC TAGGGACTGG AACCTAGTAA GTGTAGCACA TATTATITCA 'TAATCCTC ACAACAAACC CATGAGGTTG G=IIATGAT CCCAA TIT= CAGAAGAAGA AACTGATATT CAGAACCAGT TAACTAACTG GTCAAGGTC ATGCAATrC TAAGATACAG AACCAAGAGT CAAAGACATG A'TTAAACC AAAGCT1T= CTGCTACTCC ACATTGC'TrC CCTAGGTGAG ATCTGAGGCA TTCCGCGAAA AGAGAAGGGT CATAAAGCCA AGGGAAGACA AGC17AGGAA AAAAAAGGGA AATGTCCTAA ATAAACAGCT 77CCrA 1TA CCAGAAACCA CTAG'IMAAA AATATAATGG GAAAAATCCT A FTCACTTA ACAATG ITAA AAAAAAAAAA GATAGAAGAA ACATAGGGAT AAA=TAACA CA'ITGTAGG ATATGTAAAG AAACTAAAAG ATG FTAATAA TGGCCTAAAG AAAAAAAAAC 'ITACATGTAT GGGGAGATAG ACCATCTTAC TGGA TCTAA TA=~AATAG TCrAGGTGT7 CCAITCTCA CCAAAT'FAAT GTATACATI AATACAATGT CAAACGAAAT AT=TAGGAA TTGCTACAA ATrGTCAGAT AATTACAAAG TT7ACCTGGG AAATATAAGC ATATATGAAG AGTGAATGGG ACCCCACCAC TCCCCCCAAA ACAAAAAAGG TCTGAAAAGG ACAGAAATCA AGGAGAGTCT TGCCTGCCAG ATACAAAATT CTArTATAAA GGTGTA'T7GA TGAAAACAAT TAATACTAG TGTAGCAATA GGCAGCAAAG CAATGAAACA GCATAAAAAG ACCAGAACTA TACCTAATFA TGATGAAGAT TFAAGGTATG ATAAACATGA CATAAT7CAA ATCAGCAGAA ATTGGCATAG ATAGGGTTAA GACAAATAGC TAATCA17AG AGGGGAGGAA GGAAAGGAGG GAGGATAAAA T7AGGTrCCT GCCTTCATCT TACATTAAAA TAAATrCCAG ATGTATTACA TI7rAAATT 717AAAAAAA GAAACCACAA AATACTGAA GAAAATATAA GT7GTFATAT AGTCFITGA TGGGAA=I~ TfTrTC AGAGACAGGG TCTTGCTCTG TCACCTAGCC TAGAGTGCAA TGGCATGATC ATGGCTCACT GCAGC=~GA ACTCCTGGGC TCAAGTGATC CTCCCAGCTC AGCCCCCCAG GTAGCAGGAA CTACAGGCAT GCGACACCCC ATCCAACTrA rmTrATrr 'I7rGTAGAGA CAGGGGTCT GCTrTTTC CCAGGC'ITAT CTCGAACTC TGCCTTCAAG CACC-TCAGCC TCCCAAAGAG CTGGGCTGAT GGGACATTT TTAACATAGT GCCACATrAC CATAAATGAA AAGCTTGTAA AATACTAATT 'ITTAAAACTA ATATATATCA GAAAITrTA TAAACAAAGT TAAAAAGCAA ACACAAAAAA TTTGTAGCAC 7rATGACAAA TATATGTATA TATATGAATA CAAAAAGAGC CITr1ACAAAA CAGTAAGAAA ACAATGAATA CTCCCAATGG AGTATTCAAA ACTAAACTGC TAAAAGCAAT TCAAAACAAA AAACATAAAC TATGCATATA TGTATGTGAA AAAG T7AAC CTTATCAAAG AAGTAAACTC TCAAAGAAAT AAACATCAAA TAAGGAAATA GCCT1TCCC ACAAATAACC AAAATCTGTA AGAATACTGA GCTGCGAATG T=CAGAAAA AAAAAAAAAT CATACACCTA GTTCGGCATG TAATTfAATAT AGATCAGAAC ACTIAAAAA TA'ITATAGG CCAGGCACGG TGGCTCATGC CTATAATCCC AGCACT]GG GAGGCCAAGG CGGGTGGATC ACCTGAAGTC AGGAGT'7GA GACCATCCTG ACCAACATGG TGAAACCCTG TCTCTACTAA AAATACAAAA ACTAGCCAGG CATG FrGGCG TATGCTGGTA ATCCTGGCTA CTCGGGAGGC TGAGGCAGGA GAAT-FGCTTG AACCCAGGAG GTGGAGGTTG CAGTGAGCTG ACAT7GTGCC ACTGTACTCC AGCCTGGGCA ACAAGAGCAA AACTCTGTCT CAAAAAATAA TAATAAATAA AAATAAAATA ITI7ATATACT CTGACCCATC AATrGTCCA GCATAATTAG GCATGTGTAC AAGGG=~AC ACACAAGAAT GCCTAT7GCA ATATrGCTT TAATGCTAAA AAAAA1TGGG GAAAATG=T TAAAAATATA GATTAAGACT GTACATTGTG GTACAGTCAT ATAATCAATA GTATACAGCT ATrAITr1 CAGCCACT GTCCAAAATA TAGCCTGGCC TAACAACATT CTGT7AGGAT ACGCAAGCAC CGTGAGGAGA TCAGCrATAA AGTATCAGTG M~CACACCA CTGCTC='~ GCTAATAACC TrCAATGGCT TITAAAGAAG TAAAAAACAA AGGCAAAATr CCTTAGTCAG CCCTTAAGAC TCTCTGTrAC ITAGCTCAAA CTACCCITI CAACAACACT GCCCTAACCA GGATGAGTrT ITrGCCCCCC TGGAGTACAT TCAGC='~C CTTATCAAAC C=CTAA ATAAGTATcT TCTCCAGGAC CAC'ITCACTT T=ICCCCAA =IAGCATTr TCTATATCTC CAGGCCrACC TCTATAAAGC CTGTCCrAAC CACTrCAAACC CTAGCTTTI CTCTGAACTG CTAGAAATAT TITCrCTCA ITGGCCAM~ AGGTAAAAAG GITI1ACTG T1TAITACCr ACTrCAATAAA AA= =~CI TITGAGACA AGGTCTACT CTGTCGCCTA GAATGGGGGG AAGTGGTGTG ATCACAACTC ACTGCAGC= CTACCTCCCA GCTCAACAGT CCTCCCACCT CAGCCTAGTG AGTAGCTGTG ACTACAGGCA TGTGCCACCA TACCCCACTA CFTIrCATIT ITATTT GTGAGATGGA ATCTCACTAT GTTACCCAGG CTGGTCTGCT GATCTCAA17 GATCCTCCCA CrGTGGCCTC CCAAAATGCT GGGA'TrACAG GCATGAGCCA CAATATCTGG CCCCAGTAAG CTTT=AAGGC CATrAACATG AGGAACAGTG T7C=TACAC TATITATCA GCTAGGGCTT TGCATGGAGT AGGAGTTTAG TAAATGCGGT TGATGGGTrA ATCAATGTGT GAAAATA'ITC AGAGCCACCA AAAACAGATA TrATGTCTAT TCTCATCAAC AATCAAAA Tr GAGTAAACAG CCATTCTA ATACAGGAAA CCACAAAACA 'ITGAATGGTG ACATTAAAAA ATTCCCCCAG CAGGAGCCAA CCAA TITFI CATCCTGATC CAAG'ITAGCA AACTGCAAAA GATAGGAAGC ACTAATGAGT GGAAA1TTGA GTAGAAGCAT 'TrCTTATGAA GGCGT=~G ACTGGATCAC ATTAT7G CTGTTGGAGG TGCCAAATGT GTGTG'TTrAT GCTAATCCTC CACCTCAGGC AACACACAGT CAAGGATCCT ACCAAGTGTT ACCGTCAAGT GTCTGTTGGC AGCTCAAGGC CCCAGCGTG 'ITCCC'ITGCA CTAGGGAAAA GACATATTCC AGGTACAAGT ACTCCCA=T TGATGCTACA GAGGAGITFGC TGAACITGT GTCAITAATC TCTM~CGIT AGATCCCAAC CCTGn7~AAA TCCCACTATC TGCCTACTCT GGGTCITrCAC CAAM~ACTA GATCATAGTI' GGAGAAAATC TACAAAGCCT TGCTCCCTI AGA=~AAAC AGGTCTCCGT T-rAAAmTAG AA'ITGCTAAC 1TCAAGCGGG CCCTATGCG ACAGTATGCC TGTCAGTCAT ACTACATITC CTCAAYrCCA 'ITCATGTGAC TGCTCCATAC CC'=TCCCTCT CTCTTCATAC TACTA ITATC TCITrCCCCCC TCCCTCA= TTAACTGATG ATCTTG=IC CTATTrCTCTr GAGAAAATAG AAGCCATCAA AAGAGAGTTT CCACAAACTC CTACTGCCTT ATCTAGCCCT GTACCATATA CTIGCA'IT CCTCTCATrA CCATGGATGT ACTGCCTATC TGTGCICTA TCTAAGGCTA ACCCTFCCAC ITCAGITIG WO 00/09525 PCT/US99/1 7712 EPI-109 167 AATATTATCA GCTC~rACCA ACTCAAGGCC ATTGCTCTAG CAATrCTCTC ATrCTCTCTC A==TCTCC ATCAAGTIT CC=r~CTTC AA'ITAACAGA GTAGCTCCTA AAGGGAAAAA AAAGTC=CT =IrCAATGC TCATCATCAC TGGCCATCAG AGAAATGCAA ATCAAAACCA CAATGAGATA TCATCTCACA CCAGT7AGAA TGGCAATCAT TAAAAAGTCA GGAAACAACA GGTGCTGGAG AGGATGTGGA GAAATAGGAA CACTI=ACA CTG F7GGTGG GACTGTAAAC TAGUFCAACC A'ITGTGGAAG ACAGTGTGGC GATTCCTCAG GGATCTAGAA FTAGAAATAC CATfTGACCC AGCCATCCCA TFACTGGGTA TATA:CCCAAA GGATTATAAA CAATGCTGCT ATAAAGACAC ATGCACACGT ATGYTAT-rG TGGCACTACT CACAATAGCA AAGAC~rGGA ACCAACCCAA ACGTCCAACA ATGATAGACT GGATTAAGAA AATGTGGCAC ATATACACCA TGGAATACTA TGCAGCCATA AAAAATGATG AGTTCATGTC CITGTAGGG ACATGGAGGA AGCTGGAAAC CATCACTCTC AGCAAACTAT CACAAGGACA AAAAACCAAA CACTGCATGT TCTCACTCAT AGGTGGGAAT TGAACAATGA GAACACTTGG ACACAGGAAG GGGAACATCA CCCACTGGGG CCTG17GTGG GATGAGGGGA GTGGGGAGGG ATAGCATlAG GAGATATACC TAATGTTAAA TGATGAGTrA ATGGGTGCAG CACACCAACA TAGCACATGT ATACATATGT AACAAACCTG CACGI1TGTGC ACATGTACCC TAAAACTTAA AGTATAATAA AAAAATATAT ATATATATAT AAAACAACTA AAAATAAATC 'rrCITI=CT GCAGGATCAG TCCATCACCA CACACACAGG CTGTG~TrA TGTTGTTCCC CAGCTrAAGA GATCGTrCTC CAGATCCCAC TGCrCCTrCC AGTI7GTCACC TCAGTTCTCC ACTTC1T1T GCTGATAAAC TACTCTAACT AGTTACATAT GATTFCTGTC CCCAGGTCCC CTCCCTCAGT TGTITGAAC ATAATCAMT ATATCATTFA TCA=1ICAC TCTAATTGCA CAACCAAAAA CTCCCr1T =IAGATGG AGTCTCACTC TGTCACCTAG GCTGGAGTGC AGTGGCATGA TCTCGGCTCA CTCCAACCTC CGCCTCACGG GT7CAAGTGA TCCCCCTGCC TTAGCCTCCT GAATAGCTGG GATTATACAC ATGCACCACC ACACCTGGCT AATrGCT=G 7TGn71G TGTGTGTGTG TGTTITITI TTT=GGA CAGAGTCTCA CTCTGTrGCC CAGGCTAGAC TGCAGTGGCA TGATCTCAGC TCACTGCAAC CTCCACCTCC TGGG~rCAAG CGA7rCTCCT GCCTCAGCCT CCCGAGTAGC TGGGACTACA GGCATGCACC ACCATGCCAG GCTAATITI T7GTATITC AGTAGAGACC AGG171CACC ATGTrGGTCA GGCTGGTCTT GAACTCCTGA CCTCAAATGA TCTGCGCACC TGGACCTCCC AAAGTGCTGG GATTACAGAC TTGAGCTACT GCGCCGGGCT KFITGTGT7 1TrAGTAAAG ACGGGG'IMC ACCATGTTGT CCAGGCTGGT CTCAAACTCC TGACCTCAAG TGATCCGCTC GCCTCAGGCC CTCAAAGTGC TGGGA FrACA GGAGTGAGCC ACCATGCCTG GCCATAAAAC TGCCC'IMGT TAATATGACT GTTGGCCTGC ACATTGTCAA ATCCAGTGGC ATTCATCT-FA CTCGGCCAAC CTACGGCATT TGACACTGTC TGTCTTCCT TCTGflTCCTC TATCTGTrTC CAGTATACTG GCCTGGCFF C'TITACCT CTI=ATATG CTCTrCCAGT CTCAGGCTCC 1TGGGGATT TGAAGGTATG 'PTGCATnFIG CTA TCAATG AATAATGACA AGTAATGATC ACTTAAGACA 'FFAAGTGGTC AG'FrCCTA CTAGGATAAA AATAATrTC T7CCCAACAT GGGGCATATT CCAIT1CCAG TCTGACTGT7 CTGTGTAATC MIGTATrCC TrTGGCAGCCC CT1TATATC AG17CATCTA CTGTGCAGGA AATTGGACAA ACA'1GCAC TGGTATAACC AAATACAGTT GAACTrGG C=GACTCTT AGCTGAACTC ACCAAAAATA ATr7CrGTAA GAGACTGAGA CGTCTACGAG TAGGYTT=C AGAATTAGTA AACATAAATC AAGGATACAC AGGTAGATT GAA1TCAGA TAAACAACAA ATACT=r AGTATGTCTA CTGAAATATT TGTATCTTAT CTGGCAATTC TACCTGGTAC AGAACTAATC CATrCTCT7G AAAGATCTTG ACTCTGTAAT AAG~rC'=G GTGATGGAAG GGAGGTATr CTGTAATFAG AGTCACTGTC T7CCTCCCAG 'TTrATCC TGGCCCAGAT CTGCAATGAA CACACGACAG AATCCAGGGG GGATGAAGAT GGGTGCT=G CAGGAAAAAA AAATTAAAAA CATCTGAAAA AGCrI=GTA CTAAAAGAAT GTGATCTAAA AAAGAAAGCA GGAGAACTI CTGTCTGCAC TITACATCAG AACAACCTI'G GCGTCTAGAA GCTGTGCCCT GTGGGAAGTG GTGGTGCT7G GTAAGAGATG CCAGGACCAG TGGTACCCAC TGGGAGCACT GCCAATACCC AGCAAGGAGC ATGGGTGCAC AGTAAGGCAT TGCACTGTGA 117CAGCATAA AATAACAATA AGGGAACGTC ACGGAGAAAA GGCCAGACTr CC1TG'IA GAATGTGGGA AATGTCTrCT GAAAAATGcIT AGTAAAAAAG CATGCTrGGA TGGTCCACTC CAGGCAAAAC TGACTAATCG GGGGTCAGGG ATACAACCCC TGCATCATAT GMTGTrTcT GTrGGGCTGA CATGAGGTTC ACTGTGACCA CTGTGGTTA ACCCCATAGT CTCCTGGAAA TACAGCCAGG TCAAGAGAGC TCCACATAAA ACATAATCAA AAAAATAAAC TCAAGTITCC ACTGATCAGC =IICACAAC TCTFrATCCTr TCA~rAACT TGGAGCAAGA 1TrGAGAATr GGATGGCTAT TrGAGGGCTA TICTGCGCT TIrAGTTCAAT G=GTrTrCT TrCTTrA GAGAACTATG GnTMrATT ATAT'IACAC 'T[FAAG TCT AGGGTACATG TGCACAACGT GCAGATTT7GT TACACAGGTA TAAATGTGCC ATGrrGG'IT GCTGCACCCA TCAACrCGTC AT~rACA'rrA GGTATI1TCrC CTAATGCTAT CCCTCCCCCA GTCCCCCACC CCCCGACAGG CCCTGGTGTG TGATGTTCCC CTCCTGTGT CCAAGTGTTC TG'TrTATGTG ATAGA17ACG TITA'FrGATr TGTGTATGT7 GAACCAGCCT TGCATCACAG TCACTTGCTT ACAAGAAACA AACACT7CAC AGATGGATCA T7ATGTGTGA TAAGTGAAAT CCAAGGATTr ATGCTCAGAG GTGGG=~AA CAGGTAGGAA GAGCAGTATF ITFCMTCAAC CATGAGTGTA TGCAGGTI= TCTIr-IT 'ITGAGATGG AGTCTCACTC TI=ACCCAG GCTGGCGCGC AGTGGTGCGA TC=GGCTCA CTGTAACCTC TGCCACCTGG GTTCAAGCAA TTCTCCTGCC TCAGCCTCCC AAGTGGCTGG GATI'ACAGGC ACCTGCCACT GTCTCCGGCT AAIT1TGTC 'TI=AGTAG AGATGGGGTr TCACCAT=T GGCCAGCCI GT=~GAACT CCTGACCTCA TGAATCATCC TrCTCAGCCT CCCAAAGTGC TGGGATrACA GGCATGAGCC ACTGCGCCCA GCCCACAGGT TTTCAAAGA CTAAACYrAA AAAAAAAAAA AAAATFI1CCC AATGAAATAT AAAACTAAAG TGCTAAACTG TGATAGACTG =IIACAAGA ATGCCAG'IM TCACAAGTGT CTATAGAACA TGTAA'T7AG ATAGGTAAGA TGAAA'TITG ATAATA'ITG ATGGCAAATr TAAACAGGTA TACAACAAAA ATAAAATTCT AAGCCCCTCA ACCAACTGAA TGGACTCCfl CTCTCAGCCA AAGGAATACC AAAGTAAACC TGAAAAACTA GTITGGCCA GGA'ITGGGGG TAGGTGGGGG AAGCCCAACA TGACTCATTA rT~cTCCTC CC1IGGAAT TCAGGCACAA CTi3AATGTCA GCATTGACAC TAAAACACAG ATCTTAAGAC TGACAAGCCA GACTC1TGT AGCAGAGAGC CAGGCCCTGG AAGAAATCAA GTrATT=AT CCCAAAAAAT ATIT1TGA TATA=IICA AATGGCCCTG CAAAGCTGTC TCTrGTGGGG AAAATTGACA TGCTGTACAG AA=1CCTrC TCI=CCAAG TITMACTGA TCCAGGAGAG A1TrAACTAA GAGGCTAGCA TG7MTT1T 'F1TI1TI= TGAGGCGGAG TC-17GCTCTG -17GCCCAGGC TGGAGTGCAG TGGCGTGATC TCAGCTCACT GCAACCTrCG CCTCCCGGGT TCAAGCGATT CTCCTGCCTC AGCTTCCCGA GTAGCTGGGA TTACAGATCC ATGCCACTAT GCCCAGCTAA ITrrGTATr TI=GTAGAG ACAGGG TC ACCATG ITGG CCAGGCTAGT A'ITGAACTCC TGACCTCGTG ATCCGCCCAC CTCGGCCTCC CAAAGTGCTG GCATFACAGG CGTGAGCCAC CGTGCCCAGC ACAAGACAT TACCGTCTAT TCTCTCTGAA GCTACTATCT AGAGGCTrCA TCAACATAAT AAGACCCTTG GTCTCCACAA CTCCTrATCT TATCCTA'FrA G=TCTACTG ATTCCAGGTC rTAGATAAT AACAACT=1 TCAACCAATI7 GCCAATCAGA AAGTCMrGA ATCCACCTAT GAC=AAAAG CCCCACTCCT TCAAGTTATC CCGCC1TCT GGACTGAACC AATGTACACC TrATATGTGT TGATGGATAT CTGC17rGTAA CTCCAT-rCC CCTAAAATGT ATAACATCAA GCTGTAACCC AACCACCTrG GGCACATGT7 TTCAGGAACT CATGAGACTG TGTTGCAGAC C=GGTCACT CATA'IMGGC TCACAGTAAA CT7CTIAAA TATTGTATAG AG'TrGG=~ TI=CAI1GA CACAGGAAAA ATAAAGAATT GGAAGGTC~r TCATCAGTCA CTGAGCCAGC TT1CATATCTG ACTGAGGTCA TACAGTTCAG TGA'I7GTAG CTIGCTACT TAGATrGCTA TCCAT7ATCT AGAAGCATCA GGATCACGTG GGACCTATrG GAAATGCAGA C1TCCTCCT AGAACCCAGG ACCT7GGAAT AT7CTTGGCA CATAGTAGGT GCTCAATACA TATrGAACTC CTAGGTGCAA TrCAT7AA'rT CATGAATTAA TGAATTAACA CGCTCTCAAA GTTFAGTGCT FI=CACAGA CTAGTcI=C TGCCTCTTAA GCACTCAGCT CACCACGCT CCAGTCTCAC TCCCCTNFJ7A GTCTGAITAA AATCTGCrrA CATGTGAGTC TGAGATCAAG TGTTATCTCT TCTGAGAAGT CTrCCCTCAC TGGCCCAAAG GAATI7CTCC TCrATI=AG CACTGTCCCA GT7GACTrGT CATTATITCTA GTCr=CA TATPAG'ITGT =ITCATATA TATGrITAT17A AGGAAACTAG TCATITCCCC TAATAGAACA AAATTGCTGG CCI=GGGGT TGG1CAATGGA GGGGAGGCTC 'FrCT7GAAAA GGGGGAAGAG TGTrCrCCTA ATA'FTTCT TACGAGA FTr ATGTTGCTCA T=11AGCCT TTAGTCCCCC ATTGCCTGCC TACAGTTGGC AGAGACCATC TGTTCTCTCA CTGTCAGGAA CTGTCTCAAT TCTTGAAG'Tr CAGAGTCAAA AAAGAAGCAA WO 00/09525 PCT/US99/1 7712 EPI-109 168 G'IICCTrAG CTCT1 1GATC AAC1TCAAA GTITACTTC CATrGAAAA TTTACTAAGT CACCAGGAGA TGGtl7ATAC TGAGAAATAT CCACTCATAC TCT7CCTCTr CAAC1TCTT CCATATACAC CCTATTACAG GGATATAGTC T7ACrCrATA GCTCAAAAGG ATGACCCTAT CAGAAACCTG CACAGTATGT AAAACA'ITCT CACCAGAGGT TCACTIGTGT ATICCACCC TAGAATGGAA GCTCTACAAA AGCACAGAAT GTATCA FT AACT=AGAT TCTAT1TCA CACCCAGTGC T'TGACACATG A'IMGAAGTr AATAMTr TATCAAGTGA TGTIAAA ATCATGACTC ACTCAACAAA GTrATAAGAA TAAGAATAGT GTrACAGAAT TGGTATACAC AAGCTGACCA TAATCAACAC ACCTATTATC ArMfIIGC GACAGGTrCT CGCTGTCTCA CCCTrGGCTGG AGTGGAGTGG CATGACCACG GTTCACTGCA GGTFIGAACT TCCAGGCTCA AGCAATCCTC CCACCTCAGC CTCCCACATA GCTGAGCCCA CAGGTGTGTG CCACCATGTC CAGCTAA=T ITTAATTCTr TGTAGAGACA GGGTCACCCT ATGT7GCCCA AGCTGGTCT GAACTCCTTG GCTAGAGAGA TCCTCCCTCC AAGGTCCCCC AAAATGCTGG GATCTCAGGC AAGAGCCACC ATGCCTGGCC ATAATCAATA CACITIAAG AATGCTAGAA TGTrATATCA GATGCATACT TCAGCACTAT CTCAAGCAAA CTGGGGTGTG GGTITAT7CTA CATATAAAGT TCAGCAGTGT TGTTCCACAG TCCCAAACTC CAACTGAGGT CAAATGTAGG GTGCAGCAAG GTCACTGGGG CTGTCATCAA GGGCCTCTCC TFTGCACTCTT GCCAACCCTG TI7=FGATF GTCTCTACCA CCATGAGTCA CCAGCAATCT CCCACAGTCA CTrGM~AAA AGT-rCACAAG TATrGTGTGA AflGCAGGCA ACCCCTTGAC TCCCTGA'rTG CCTGGTCT7C TrCC-rrGGGC TCTACCA Tff 7=TCCCCA GCACTCTrC TGC-rGcTcTA AATITAATT CATGCAATTC CATATGTGTT TCTCTATCAT TCTTCATCTC M~CCTCTCC MTCCATCCA ATITG TT7G TCTGTrGCT TGC'ITGCrG CTI1AATACA YT7CTCrI= TCTGAGAAGG CT7GAGTCCA AAACTCTCAG TrACCTGTTG TTCTGTTCC CGTTAGTrAA TCTCCGAACC TrCATAAATT AAATCTGACA AAGTCCCCTG ACTAACAAAG GAAATGCACA AGTCACAGTA AAAGGGGCAC ACACAGAACA CAAATAGACC CAGGGTC'= TCTGTTCATC ACTCAGC'= TFATAGGAGA TCCAGGAGAA ATGAAGTGGA AAGGGAAGTG TGTTGAGFA CTATACAACA CAAGAGTAAA CTTCT7ATA AGTGGTAAIT ~ITITI ACA GGAATAATTG AAAATGGAAA FFACCTTCTC TACTCATAGT AAGTACTCAG TGCGT-rC1TG ATGGGATGAG AATGTG'TrFG AGC1T7AGTG TAAGGCAGAA TrCTGM~AG TCTGCCAGTA T7GGAGAAAA ATAAAACACA AAGGGACTGA CATGTAGGAA GTGGCACCTG GGAGGGTCTC AAT7=ICCT ATrACAAAAA TGCCCCAGAG AAATAAAAAG CTTGTGTACA TGTTGAGATG GGAGAGT7CT CTGGCCCCCC TCGCAGGATG TGTGACAGTG GGGTGGCTCT CTGCTGCGCC ACCATGAGCT CAAACCCCTC ATAGGAGGGG GAGCACACAG GCAGGAAGGT GCAGGAGCTG GGCGAGCTCT 7FGGGCTCTG GCCCCGTGGT ACTGTCTAGA GGTGGGTGCC TGCAACTCCT GAAAGCCCAA GTGGGCATGT GTTACAGTGC ACTCT=CAG ='TGCTGTC TGCAGCTTAA GCGTTAACCA GCTCAGTTrC T7=~GGTAC CCAGGTCCflT GTCTGGCATC CAGGAAGAAT CAGGTFTACAC ATGGACT'rGA AGGATGAATG TGGGAGIT= ATGGAGTGGT GGAGGTGGCT CTCAGTGGGA TGGATGGGGA GCTGGAAGGG GGATGGAGTG GGAAGATGAT AT7CTCCTGG AG'IMGGCTG TCCAGCAGCC GATCTCCTCT CCAGTCGTCC CCAGCCTCTC GACG'rCAGA TGCTCCTCTT CTCTCCTCT CTGCCATGCT GTTCTGCCGT TCATCTGCCT GTCTCTCTCT GGAGCCTGGA ATIGGGGTr TATATGGTAC ACAATAAGGG GCATGGCAGG CCAAAAGGGA ACTITAGG TGCAAAAAAC AGGAATGCCT CTTCTCACTr AGGGCTATAG AT1TCAGGC TrGAAGGTGG GGCC'=ACC AGCGAACCTG TATTrCCCTG TCTCCTGTGC ATATCAATGT AATCAAATAC TGGGCTGATC CAGGATGTTT7 C'TAGACCA ATrATGGGTA AAATAATITA CATTCAGG'Fr TrlATATTG C1TYGTCAT 'ITCTITTAA GCAATCATGT AAAATATCTA TACGACAGTA ATAGATGATA GCGAACCTAA TTAAAATTAC CAGAAACTTA AGAATCrCTA ATGATrT7CAA CTGTAACTAA GGTFATIT7CT CT'ATGTrG AACAATGT7G GGAGATAAGA CACAAGAGTr TCTGAAGTAT TTCAGAAACA CAAAGAGGGA GGTrATATAA ATAATATIT ITCCTA=T TGGGAAAATG AAAGCTAGTC ACAAAGTTAA ACGAGTGGTT ATM~AATAT TrAAAATACA GGCTGGATG TA'IMCCTGT TAAAGAAAAT AAAATGCAGA ATA'ITCAAAA CGTCTGACCA CCCTrCTAAG AAAATGCATC TCTGAGGTAT T1TCCT~rAG AAGTTAT7GT AAAAATCCTG GAGAAGCTTrG AACACAGCAA AGCAAACAGG ATGCAGAGTT TAATCTGTGG AAAGCIAGG GAAGAAAAGC AAATCA I1AA AAATAGGTCT TCCTCTGAAG AITTAAAA CGCAAAGAGG GTGGAATAGC AATGATAATA AAAAAGCTGG CATAGAGAGT GGCACAATIT GCTGTGCCAC TGAGCTGACT GGATGTGTTC TGAATrCTA GGCATrAGTG TACC1TCCA CACGCATTCT CCC'=AAAA AAAATGCCCA CACACTGAAT ACTITITCA TGCAATITAA AATAAGCGCA CCATCTAGrr TACAGAAATr CACTAGAAGT TA'I=ATCCT AAAATAGCAG AGATCTAGAA GAA'ITGAG CTCTAGGACA TI=AGACAC ACAGAAAGAA GAATCTGGAC AAGTCTGAC CAGACATGAC AGAATAGAAA TTT7CTICC TATMATCTC 'TrGAATAAA A=r~CAGGA TCTACAGTG GACAAG IMG TTATCTACAC ATTGTGAAGC ACATrGA'IM CTCCTCTGTA GCCTTAGGAA GATCTGAGAG GTGACTGAGC TGATTGAATG ATCCGTGACC GVITCTACTGG GACCAGTAGT AGAAC'ITAC TGGTGGAGAC CTGCTGGAGG TIT7GAGAGCA GAC1TGAAA ATTACTAGAG CTACACAGAT ACTGTGTGGC TAACTGGATT ATGTITAGAG GC1TCAGAA CTATGCTGCT GCTGCTGCAG TGTAGCCAGG ACGCACAGAG AACATCTAAG GCTC7FGAAT GGGGCGATAG GGACAGAm' CAGCAGCCAT CTGACT7CAG TGCTCATIT GATGCI=CC CTGCAGGGTG CAGTGTGCAG TGTGCAGTGT GCAGTGGTGG GAGGCTCACA CAGGAATACT TGCTICTGTA GCCCTAA'IM CCGGTrCAAA CTCTGCAT7C ACCITrGACAG ATrT=CCT TGGCCAAAAT 'FrAGTTAGGC TTCTGGGCFF TCTMTATGC CCACCTGCAG ACTITIGGT AAAATCCAGT TIAGTAAAG AGCTCTGCTA AGTCAGTrA GCAAGAATCC CCACCTCAAA AGTCACTATC TCCCTCCCTG GTAGTGTCTG GCTrGTCITC AGCGAGAAT7 CTATrAGGTF CTG FrAGATr AGAATCCTrCC 17ACCCTTGA TGCTTCCTCT TAGTA TIT TCATCCACTG ACTCCITGAC CCACCTTGCT CCTCGGCTAT AAATrCCCAC TrGCCCATAC TCTGCAG I1A AGACTATI= CTCCCCACTA CTGCAAAATC CCATTGCCAT GGTCCCTATA CTATCTCAAT GGTAATGAAT AAAGTCrGCC TrACCATGCT T7AACAAGTA ACATTGAACC AITThTCT TIFAACAATCT GCTGCACAAT GAGATTACTA AAACT1TTATT CCAITIGCC ATGCTGGATG TCCTCAATGG AATGGCTCT GTGAGCACCA AATCATrrGTG AGAAGGAAAA CCCATCTCT ACAGCCCCCT GTAACGTGAT GTATGTrACA TGTGATGTAT GTTACATAGT TFTT=CAT GT7GATCACT TITGCCCAT TITCCTATAT CTTATCAGTr GGAAGACTGT GGAAGTIT7GT AGTACTAAGC CACAAGATGA CTAAGAAGAG TrGAAAGGGC AAGTGGGGCT AAAAACAGAT TGIMGAC TTACCCCACC ATI'CCCCCTA TCATGGGGCT GAATCTGCCTr GGAGGAAGGA GCATCTIAT CITGTACTG TGAACCACAC AGTCTAGCAG CAGCACAGCC AAGGCA=TG GGG ITCATG AGACTAAGTA CATGCAATFC TATrGTAAAG GC =AAAATA TATACAACTG ACCCTTGAAC AACATGAAT7 TGAATrTGCAT GGTCAGTrAT ACGCAGA TTr TCITCCACCT CTGCCACCCC TGAGACAGTA AGATCAATCA ATCCTCfl7CC TCCTACTCCT CAGTCTACTC AAAGATACTr GAAGTCrACT TGAAGATGAC AAGCACAAAG ACMT=ATGA TGATCCACTr CCACT7AGTG AATAGTAAAT ATGT1TCTC TrCCTCCTAA TM~AACA CYICTTCTC TCTAGCTTAA n7rA'FrGTrA AGAATACAAT CTATAATACA TATGACATAC AAAATATGTC TTAGTrGACT GrrrATGT7A TCTGTAAGGC TTCAGGTCAA GAGTATGCTA T-rAGTGGTrA AGTITCGAG GAGTCAAAAG GTGTATGTGG ACTPCAACT GCAGGGGGGT GGGCACCCCT GCCCCCATGT TGITCAAGGG TCAACTrTAC TGCCAAAGGC AAGCC'=AC ATCCAC7Tr TCCATCCCAT CAGTAAATGG AAAAAGATAG CTACAGTATC CCTGCGTCAA ATCTTT T rGCAGATCA CAAATrGGCC ACTCACCTrG CTCTGTGAGG GGTAAAATGC CCCAC'=CT ITAGTAATAT TrAAG'TrAGA TAATATrAA GTrATAAAGT TGT7CIGT AATCGTTAAT TGTAATflT ACATAG ITTC MICAAACAG AAATAGCAT7 7GTTAGAT AACCTCCCGT ATAGATGATG AAACTCCTT TAAGGGCTAT CTGAATITA A77CC'rTGAA AAGGCAGAAA TTGGATAGCT AGTAGTCATA AATGTACTGT GGCTrCCCCC AACCATCTGG GCTATATAGA AGCTGCATCC 'ITGGACTGCA GTAGAGGAGT CTI7ACAAAGC ACAGAGCAAC TTCTCTCCTG GGTIrGCGCTA GTrATGATGG CAATM~AAA TGTGTACIT TACCCAAAGA AAATCCrTAT TATCAACAAT CACAATGCCA TCATAACCAT GGTATAAAAA ATTCAAAATG TCCCAGCTGA AGTGGAGGCA AAGACTCAAG TTCATGGAGT CAGAGTTTCC T7rGCTA'rrCC TC r=CAA ATGACCA TTr AGTAAGCACC TGAAGAAAAT ACTATGGACG GCA'ITGAAAA GTGAAGATAG G'ITrAATC= CTCGAAAATC TAATTCTCCA GATGAAACGC TGACACTrAT CCACCCCACA GACCCTATAG CAGATGTGTC ACTGGCCATC ACATrGACA WO 00/09525 PCT/US99/17712 EPI-109 169 CAGAGAAGTC ATAACTCAGT CAGCACAGAG ACAT=TCCAT GAGTTTCTGA ACCATGGACA GAACGTCGTC TGTGGGACAT GAAAACTGGA ACTTAGAGGA CAGGCACATC TGAGAAATGG GCAGTMTAAA GGCAGAACAT AGCACATATG TGACTGGGTT TTAGAAGCAA ATTACAAGA CGCACTCTTC TTCATCCTAA ATAATCTGCA ACCAAAGCTT CCAAAAAAGA CAATTAGGA ATGCAGAGGT GAGGAGTAGG GAGGGGAATG GGATGAGAGA GAGTGGAGAT TAATGGTGGG CAGAGCGAGG ITAGAACTT AGTGGTTCT TCAGGTTCTG AACTGAAATT TGTATACTGT AAAGGCACAA ACACCA TT TAACAAAAGT GAGCAGGACT TCCTATCTGG TTCAGAAAAT AGGTGAATAA ATAGTACGAA TTATrAAAAA TAATAATTC CACTTATACA TAGGAAACTT GATAGGAACC ATGATAAATG CTTAACTCTT AATCTTCAAG GAACTCTGCT AGGGATATAA TATTATAAAT CTTGTTGC AGATGGAGAA ATTGAATTT AACCCAAGTT ATCATAACCC TTAAATGATr AAATGATACT GTTACATGAG AAAGCTGCGT ATCTG'TTCC TGGATTGTA GCCATAATT GTGTCTCAAG TCCC TITGC TGCCAGCTAT CTTGGGTAGG TGTGTTCCCT TTGGGCTGTT TGATACCCCC ACATATCT 'TTTriTC TCITITITIG TTGAGAGAGT CTTTCCCTGT TGCCTAGGCT GGAGGGCAAT GGCGCGATCT CGGCTCACTG CAACCTCCGC CTCCTGGGTT CAAGTGCTTC TCACGATTCT CTTGTCCCAG CCTCTCTAAT AGCTCGGATT ACTGGCATGC ACCACCACGC CCACCTAATT TTGTATFT AGTAGACAAG GGGTCTCC ATGTTGGTCA GGGTGGTCTC AAACTCCTGA CCTCAGGTGA TCTGCCTGCC TrGGCCTCCC AAAGTGCTGG GATTACAGGT GTGAGCCACC ATGCCTGGCC CCAAATTTAT CTTTAATGCC CCAAATTATC TAGTrCCCAT GACTGGGCTT CTGCTrGAT CCTCTGCA CTTGCTGGAC CCTCTCCCTG GGAAATGAGA TTGTGTCCTG AGCCCCTAGT TAGAGGCTAT GTCTCTGCTG TrCCTGAATG GGCCTCCTGG ATGAGACCTC ATTAAAAGTC TAATrCTCTT GGAGAATrGA GAGATACCTA TTTGTCTCAA AATCATrGAA ACCAATTAAT GTATTATGAG CCTCTATCCA GTGATTGTA CCTCAATTCC CCAATCCAGC TGTCAAGGCC AATGTTCT ACCTTACCTA GTAGGTAAGT CTGGAATTGT AGCTGTGGCA T=TTCAGTAA TGGTACTCTA GGTTAGCAGT CCCCAACCTT TTTGGCACCA GGGACCAGTT TTGTGGAAGA CAA'ITITCC ATGAAGGGCT GGGCAGGGGA GTGGTTrCAG GATGAAACTG TrCCACCTCA GATCATCAGG CATrAGATTC TCACAAGGAG TGCGCAAGCT AGATCCCTCA CACATGCAGT TCACAATAGG GTGTGCACTC CCATGAGAAT CTAACACCGC TGCTGATCTG ACAGGAGACA GAGCTCAGGC AGTAATACTC ATTGCCTAC CGCTCACCTC CTGCCGTGCA GCTCAGTTCC TAACAGGCCA CGGACCAGTA CTGGTCCACG GCGCAGGCAT CAGGGACCCC TGTTGCTAGG TATAAGCATC TGGCTGCTGC ATGTCTTCTG TGTAGCTACA TCTGTATGTG TATCTGATGA GATATAAATTr ATGATTAT AAATrACTTT CTTCATATTA GAGTTGTGAA TGAGTATCAC ATATAATTAT ACATAAACTA GGAATATGCT FTTAATAAT GTATATAAGT AAGTCCTT AACTATGACT TTCATCTrAG CGTAGTAAGA GGGTGCTAAG AAATATTTGT GATGAAAATA GGCATTGGTA GAGT'TGAGAC CACTGGGTGA TGAAAGAGTG TAAAGATT AAAGCCTTCA GATGCTGGTT CAAGGTGAGA AATGTGATTG GGAGCAAATC AATTAACTTC TTGAAGTCTT ATAGGGCAGT TATGAATACT TAATGTTAAC ATATGTAAAG CTCTTCTGCC CTGTATACAG TAAATGCTAG TFAGCTATTA TGATCACTAC TAAAATGGGG ATGACATAAA CCTCATAAGG -1T-AAGTAT TATGCAAGAT ACTATACAAA GTCCAGTAAA TATCACATTC AATTGAATCC ATGATGTCCG ATTAITTAG CTACTrCCAA GAGAGAAAAA AATGCTGTCA GTTTTACTGT TCTTATAGAG AGCAAGGCAG ATCCCAATTC CCAATGTGGT AACGTGAAAA -ITITrGCATr TGAATCAACA AAACACTTTC TCCTTTCTTT CCTACTAT AACAACTGGT AAGTCTATAC TCCCCCAAAT CTGGAATTCT CCTCTTAT TCTITilCCT CCTACCAAGA CCGCAGGATC TTTACT7GG CTATAAGGGG TAAACCTCAA GTAGTACAAG TTCTCTGTAT TACTillATA CTCTGTCACA GATTCCC1TT GTTTCCTCAT CTCCATGTGA ATTTAGTrAA ATTCTCAGCA TTCTGATCCT TACTATACAA GGTAAATGAA TATAAAAACA AAACGAAACA AAAACCTCTT CCTATTTACA TAAGGCCCCA ACCTAATATT TAGTGATATA TATTAATGTG AACAAGGAAC TAACGAAGAC TGGGAAGAAA TTCACAGACT TGAGAGAAGA AATGGCAGGA 1TTCCTGGGA ACAATTCAT GTAACGTCAA AGGTGGTAAA AGGTCAAATA GAATGAAGAT GGAGAATACC GGATITTCTT ACAAAATGAT TTCCCAGGAG ATCTCATCAA ATGCACGAGG ATACCTTCTC AGTTTCACCT AGTGAGTAAA AGACTGGTAA CATAGCTCAC TTACAATTTG GATAAACAAA ACTAAACAAA CAACATCAAA ATTTCAGAAA AAATAATAGC AAAACAGAAA TCAAACACTC AAAr11ITGG TCCTTCTGTT TATTCAT7 TGGATACTCA GTGAATGTTA ATTAACCAGG AAACTTAAAA GTTAITTCAA TTATGAACCT CTTCAATCCT TCATCAATrA TTTGAGTAT TCTGGTCTTA AAAACATCTC TTTCTrTCAC AAACITCTGA AAGAGATGAA CACCTCCACC TACACCAAAA TAATGTGCTT TGCTGGCCAA AAGTACACGT CCA'TI1AC TTAACAGTCT AAGGAAAGTC TGGTGCAAAT TACTATAATA ATCTGGGTG TAAATGGTTT CTGAGGTGAG AATGAGATCA TATTTTACAA AAAGITilTC ACTACTTAGT ACAAGCTTAC AAAACTCAGA CCACTCACCA GAAAAAAATC GGCATTTATA TAGTTGTGTr ACTIllGGTT TCCTGCATCT T7CACATCT GGCTCATTTA CATCATi-C TTCATCTTCC AAAGTGGAGT TAGCTACTAC ATTAGGTAAG GTTACTTCAT CAATCACCAT ACTGTrATAA TCTTGAAAGT GAATTTCTT GGACCCTCCC TTGAATGCAG TTATACCTAG TAAACCTGAT CCACAACCAA GATCCAAGAC I1T1-ICCCA GCAAATTTCA C=TGGCCTT TGTGAAATAA GCCAGGAGGT CAAAGGTACA TFCCCAGATT TTTAAGCCTC CCTCATAAAC ACCTGTAATC AGATCAGAGT GAGAAGAAAA GCITI-TGAA ACTATGT=TT CTCCAGGGAA GTTCTCTTC AACAAGATGG TTTCACTAC TGATAACTTA ACATGCTGGA AACCTGGTAA TGTTTCTATG ACTTATTT CTAACATCTT CTTTAAATCT TITAGGCATAG CATGCTCT GGCAGCTCTC AAGGAGGGCT GTTTCCATG TGGCTCCAAG TTCCTTGAAC TGCTGGCTGC ACTGAGTGGA CTGTCTGTGT CTTGAGAGGG AGCTGCAT TCCATTGACT TATGTTCCCA CAAGTGATCC TGAGGCAAGT CAAATTGTTC TGCAGAACAT TTCTGTCCC TCTCTTCTCC TITITGACTT TCTGAGACTG ACAGCTC=TT TGAGGAATCC AGGGTCAAAG CTCCATCTCT AATGGGTGTT AATTCATT CCAGATGGTC TTCTATAGTG AAATTAAACT GAAAGGTCAT CCTCTTATTA AATGCACACA ATCTAAAT TCAGATTCTT CAACTTCTGG ATAGAATTTG ATGATACACA CAAATCTGCC TCAATTATTC AATTAGTT GTTGGGCCCA ATITCTCTTT AGCAGCTTAT ACATGGTAAC AAATATTTAG AGATATITCC AAATGACTT TTAGACGTCT TTGGTCCTCT TTCCAAGCAG CTCTGGAAAG AAAAAAAAAA AAAAAAGAAA GAAAATGATG ATTAAAGCAA AATGGCACAT TTCACTAAAG TGTAATATTA AACAGCCACC CCCACCCCTC CCTGTCCCAC CATACAGCTG CTITCTTA AAAAGTTGTG GGGAAGAGAG AGAGATAAGA GATGGACA CTCATACACA CCTTAAGGGT TCCAAAGTGG GAGAAGAAAA TCAACTATAA AAACAAACAG AAGAACAACA GCAACCACCA CCACTACCAC CTGGACAAAC ATAAAGTCCA AGATAT7CAG ACAGGACAGC CTAGCTACTT GCTGTCTTC AGCTGTCTTG ATrGTGTCC AACCATATrC ACCCCCTAAG CTTCCAGAAT AACTTCACTT CTGTCTiT1A CAGAAGAGGT GCAGTATTIT ATITTGGTAA GTCAGCGTCC CTTAAAAAC ATGCATAGGT ATGGCCTGGT GTGTGTAAAT TCATCCAAGA CTTCACTCCA AACATTrAGT CGAGAACAGC AGCCCTAAGT GTATAGAAGT GGGGGTAATT TGGCAATAAT TAGTAAAGAC TAATTCGGTG GCAGAGCAAA CGCAAACTAG GGCACTGCAG TAGTTTGGAG AGACCTGTAG AAATAAGAAG CAACTATf GAGAATCTTC TATCTACTGC GCTAGACACT ATACCATCTG CCTCAATITT CACAGTTCTG GCAAGTGGGA TCTTTGTTCC CTTTATACAA GATTTACAAT TTGGGGGAGA GGCGGGTCAC CCAGTCCCGC GGCTAGGAAC GCGCCTCT CCTCTCCCAT CACGCTGCAA GGCTTGGAGT CACTTCCGGC TGCAGGTCCC GGAACAAATC CGACCCCAGA AGTGGGGACT TCTGGCCCTC ACCTCCCCAT TTGAATGTAA TGTTTACAGT GATCCAGACC TGGGGATGCT TGCTfCCCGA CGTGTCCTGG GATCGCGCTT CTGAAAAAGC TCACCTCACA ACGCCTCCTC CGGACCTAAA TCGCGCACCA GTGAGTCGAG TCCTCCAGGG GCTAGAGAAG CCCGACTC TCCGGCCT TGAGGGACCC GGGCTCACCA AGAAACCAGC CGCCCTCCTC TCTATGGTTr TGGAGCCGGC GGAGAGCGCG CAAGGGTTGG CGGGACTGCG AGTTTCCGGT CTGGGCTG GCGGGTCTGG TTTGAAGCTC TCCTGITTGA CGAAAGTATG TCTCAGGAAG GTGCGGTCCC AGCTAGCGCG GTTCCCCTGG AAGAATTAAG TAGCTGGCCA GAGGAGCTAT GCCGCCGGGA ACTGCCGTCC GTCCTGCCCC GACTCCTCAT ATCCTTCCTT GGTTGTCACT TCTACCTAGA GAAGGGTGTG GGCGGGTCGC GAACCTCT CTTCTGTCCC TTCAGACCCA CCGCCAGGCT GGGTTATATT ACCGCGGCCT GAACCCCCTC TTTTCTTTGT CAGTGAGTGG GATGAAAAGT GAGGGACTGG AGGGGAAGCG ACAACCGTGG TAGATAAG TAAGGCTG GCCCTGGAAA GCCTCGCGGA CGTGTTCTGA CCCAAGGTFr TAGCAGTGGA TGTGGCGT TCTTCCATTC CTTCTTTCAG TTTCTGTA WO 00/09525 PCT/US99/17712 EPI-109 170 CTCGTrGCTT GCAATTAAGT GTAAATACTr TTGCTAGTGG ATAATGGGGG AGGCAAGGAC TGAGACCTGC GGTATGACGA TAGCTCTGGC TCTrAATAGT TGAGGTAAA GCGAGATACT CTGAGCTIT GTCTCCCGTA AAAAGGGTGG TGAATATGAA TAAGGG=rr CTrAGCGTTA TAAGAATTAA AGGGCATAGT TCTGTGGTGT GAAATCTIA AAAGATGTrC AGTAAATAAA AATGATIT7C CTCCT=CCCC TCTCAGACCT C~irr=Cr TMrCTr 'TITrGAC AAGTTCTCAC TCCTCTCACC CAGGCTGGAG TCI=CTGAA AGAG17=TC CG=TGT7GT TGGC1TCAA CTGTTGGATT TGAGGCGCTT AGCGCCTTCT TCGTCCGGGT GCAGCACATF CT-TGA FrGGT CTCATGCC FT TGTGGrGTA AATGTGCCTG GAATCCTAGC CTICATGGT AAACCATATG TATATGTATC 1TITCACAA CAT I~rGAGCC CAG='~ATA CAATrACACT CAAAAGAAAA AAAGTAACCT TCACTTGAGA GAATCTCAAT A~TGCACAAA TATGTGCAG CTAAAGCCCT ATGTAATCAC ATAGAAGTCA TfrCACCTAGG CATTAGCAAA ATCTCAGAAG GTGCCAAAGC CCCCTflrT AG TI=GTG TAGGTACAGA ACTGCCGTCT TCAAGGAGTr TCAA=~GAA AACAAATAGC CACCCTCAAA ACATrCAAAA ACACTTAAAC TGCGTGCATA ATGTGTGTGA GACATGGTGT TAGGCT=GG GAGAACAGAG ACACGGAACG TGATrCCTCT TCTTCCCCAC AAGC=ATAG AGAGA=~CA TrAAGTrGAA AGTCAACAT'r CCCACCTAGC MFGCACTC AAACGACATA TrCAAAAAAG CCCAAAC=C CTCTAGTIT CITCATCTGA GTAAATGGTF TCACAAACrG AAACCrrGAA TCCTCTCTGT CTCACACACC CGATCAGTAA GTrCTATTGT TrCTGAT7CC AAACTATGTC TTGAATCAAT CCGMTATCT CCATCCrCAT TGCTACCACT CTGA'ITCCAA ACCCTTATCA CCTCTCACTr GGAGTATTAA TAGTrrCCT GT7TCTACTC ATAA TCATT ATTCCAAAAA AGTTAAGAGG GGAAAAACAT AGATCTCGTC A'1TCCCM~ TTAAACCACT T7ACCT7CAA GGTrCCAGGT GATCTAAGCC Tr1GCCCTTCT CTCATACCTA GTTAATrAAC TACACTCT'GT TCATGAATAC ATTAGGCTCA CCTACCTCAA GAT~TrITG CTCAGCCTGA TITG7TrCr CAGCCTITIG CATATITCAT G'I7rATGTCT TGGCCCAAAT GTCAC17CCT TAGAGGGGCT TITCAGAGC CTTCAATCT AGGCAGTTCC CCCAAACGCA GTC'PrACACT TGTATCACAT TGGCCTGT7C AG=ICTAA AAAGCACA1T ACCATrAAAA GAAATGCTCT TGTI'TGC'= GTATA1TrC CA=TCTACA CATTATGTTG CAAAGTrCAT AAAGGCAGGA TGTrGAITI CTTCACAGCG 'FrACCCTCAG CACCTrAGAAC AGTGCCTGAC ACATAGTAAG CA ITCAT[AA AGGGCTAAAA ATAT17CATG 'I=AAAAAT ACT1GGGAGT CTAATTAGAC AATAC'TIT 7rICAGC17AA TGGTAGTAT TTAGC'ITCAC TA 7AACA AATGAAAAAT T7GCAATAAA TCTACAATGC CATTACCCCC CAAAATC TT'CATG'I= GCA'F'TACG TATI7A'I=C CAGGCCTTrAC CTGCATGTCT GCATAATCAT AACTGACTAA =IIGGAACA GCTGGTAATT A'FTrGAGC'IT TACTGAAATT TI=CATGAG GCCAATrCTA CCCTACTGAA CTCAAATITG AGTTAATGAT GACCTCATTT7 TGATTGCTGC TGTAAAAAAT AAGATCGG AAGAGGAATG AATrC'IGTA TITACTGTGGT AGGACTATGG G'TITITr GT~rTG=~GT T7GTTIGAG ACGGAGTCTC ACCCTGTCAC CCAGGCTGGA GTGCAGTGGT GCGATCTCAG CTCACAGCAG CCAGGTTCAA GTGA77CTCC T7CCTCAGCC TCCCGAGTAG CTGAGA17AC AGGCACGTGC CACCATGCCC GGCTAATIT TTGTATC'= AGTAGAGATG G T]7CACCAT GTrGGCCAGG CTGGTCTCGA ACTCCTGACC TCGTGATCCG CCTGCCTCAG CCTCCCAAAG TGCTGGGACT ACAGGCGTGA GCCACCGTGC CCGGCCGGGT TAT7CATIT TCTrATTAAC ATTC1TGAT GA~rCl7ATG GTGrrGT7AC AGTAAAACAT 7rCTAACAAT TATTCTAACA ArArrC-rr ATGGTGTATA TGAAGAATI1 A7TGTCGTGT An7TGTAAGC TGCTATGTGC AGAAGAAT7r CAGTCAAATA AAGTT1GGTAA GATAGGTATG TAAGTAATAT GAAAAAAGAT AGAAGGTGAT GAGTGACTTA GGTATAAATT AAGTACAATA GAAATG'ITGA GGAAAGAAAA ATICT7GTA ATAGAAATCG GAAGTACAAA CTGGGCATGG TGGTGTGCAT CTCTAATCCC AGCTCCT-rGA GAGGCTGGTA TGGGAGGATC AC1TAGCCC AGGAGCTGA GGCTGCAGTG AGGTGTGATC ATGTCACCGC ACTCCATCCT GGGTGACAGC AAGACCGTCT CTCTTI T TrrrI=GA GACGGAGTCT CGCCTATGCT GGAGTGCAAT GGCGCGATCT TGGCTCACTG CAACCTCTGC CTCCCAGTIT7 CAAGTGATTC TCCTGCCTCA GCCTCCTGAG CAGCTGGGAT TACAGGTGTG CGCCACCATG CCCAGCTAAT TATITGTAT TIAAGTAGA GACGGGTTCT CACCATACTG GCCAGGCTrGG TCTTCAACTC CrGACCTCTT GTTCGCCCAT CTAGGTCTCC CAAAGTGCTG GGATFACAGG TGTGAGCCAC CCCACTTGGC CCCGAGCGAG ACCCTCTCTC TAAAAAAAAA TAAATAAATA AATCATAAAC CTGTGGATrA TrGTAGCA F[ GMTCTCATC TGTCAAAAAT A TTCATGAC TATGCATAGT TrGAAAAGGC AAG1TGTCC CTrGGGCAATr TTCAAAATAT T7aIMAATG TGTITCACA ATACTG'IMA CCTAATAAAT CTAAG 1F TAAAAGCAAA A17AAGCCAG TAA'ITGAGT CCAATTCCAA TCTTATGA GTCATrGCT7 AAAT'1rCAAA AGGG=ITAT nTI=fTA GGTITUCT GAGTAATGAA TACCCTA17A CTATGATACT AGTATCTTCC T7AATTATCC TACTCAT7GT CTCAACAT7C TGACAGTTGG ATFGAGCATA TrCGTAAGTA AAAT7GTIT AACTGTATGA TGTACITGA TGTTAAGGTC CGAGTCCCCA CATACCTCGG TAGATGTG17 CTACAGTIT TGTATTCCCT TGAAATGTAA CTGTTCTCTA TGTTACAGCC MrATAACCT TCAGTTA=~ GAAATGAACA AATrCATrCA AA~rCCAGCA C1TAAAAG Fr TFTAAAT7ACA '17GGATAA ATACCAAAGT GTFIGTTGA TGATGTATGT ATAAACAAAT TGTAAATATT AAACG ITAGT TG'TTACGArr AGACCTATAT AAAACATGAT ATGCAGTCTA CTGAATAGCT ATCAGCCTCT AACATG'IMA GTGTCATrA GAAAATG=T TCTAAAFrGC CAAAAGCTGA 'FrGTCTAGGT GATAACAAAT TrACCA M G GAGGAAGTrG ACTICTCAT TTTCATGTCT TCATCAGTCT TACTGATGA GATTCATTCT TCrAGTCAGA AGAGAGM~A GACTGCTCAG TTTACTCATA TI=GAGT-rA GCTI=CTAT TTAGAG FrCA CT7GG TTGTG GAATATrCAT TTATAATrG AATCTACGTr GTGTAATGGG ACCTAATIT 7rn=C=' GTI=G'rrG GAGTCTCGT7 TTGTCACCCA GGTTGGAGTG CAGTGGCGTG ATCT1GCTC ACTGCAACCT CCACCTCCA GG3TTCAGGTG ATTCCTGC CTCAGTCTCC CAAGTAGCTG GGATTACAGG CATGCTTCAC CACGCCTGGC TAATIT=GT ATI=AGTA GAGATGGGGT 17CACCATGT TGGCCAGGCT GGTCTCAAAA CTCCTGAGCT CAAGTGATCC TCCTGCCT7G GCCTCCATAA GTGCTGGGAT TACAGGCGTG AGCCGCTGAG CCTGGCCCCA GAGTrrGTI7 TGTI=G'I TCAAGACAAG ATCTCACTCT AT7GCCCAGG CTGGAGAGCA GTAGTGCGAT CATAGCTCAC TGCAGCCTGA ACTCCTGGGT TCAAGCTATr CTCCTGCCTC CATCTTCTAA AGTGCTGTGA TrACAGGTCT GAGCCATGAT GCT]7GGCCTG TGTrrIGTI TGTrGTr GGGGGACAGG GTCTrGCIT GTCACCAAAA CTGGAGTGTA GTGGTGCGAA CATAGCTAGC TCACTGCAGC CTCCATCTCC CACGCTCAAG CAATCCTCTC ACCTCAGCCT TCCAAGTAGC TGAGACCGCA GGTGCGTGCT ACCATGCGTG GCTAA7TTC TAM~ATATA nl7ATTr GGTAGACATG AGGTCTrGTC ATGT-17CCCA GGTGGT=11 AACTCCTGGG CTCAGACAGT CCTCCCGCCT CAGCCACCCA AAGTGTTGGG ATI'ACAGGCG TGAGCCACCA TGCGTGGCAT AATI-hT= AAGTAAA'ITA TIT1TFATC TITGAGTATAG AAGTGATrCA TGTrCATFGT GGAAAATATG AAACATATAG AAAAACAGAA AAGATTACAA AACATCTAAT CTGAAATGGT TAAGATITG ATGAGAACAG TCTCATCTCA TrICCGTATA TTCCTGCCAG CCTATCCATC ATrcTTCGTA CATGTTTATC TACA TAAAA T7GGTGT7AT A T=GGAAA CnTrrcTrr AACTACATTG TGAACA'n= TCATGTI=A AAATGTCA1T 77AATGATGG CAGATCCTAT TCAATAGATG TACACACACC TA IMAACTG GTCCACAATT GflGGATATG TAGGTCG TT CCIrCTCTC TnTTrlT TTMPGGCTA CTACTAATA GTIT7CTCTGT ATAGAATGTG GTATFIGAA AGTGTATCAA Gu I I AGATT 'GGTAGTATTC TITGCAT-1TAA TAAAGGGCAG TGGCC1TGT TGACTGACAT GACAATAI7Tr I1ATAAAAT1? TGTrA'TrrGC 1ACAGAAA TITGAAAAT TATrGTAGAA ATG'ITTAC GTCATATGAA CCACCTrGACA TrGGAACAGA =Cl rII IC ACAAGTGTrA CCAAAGGTAT AATACTA FrA CCTGAAAATA CATGT7ATAA GGAATCTAGC CTCAGTCT7A GATGAM~AT TATTAATrAT GGCTCTCIT TTCTAATATA TCAAATATAT TCAAAATAAA AATAAGGAGT AAGTAGATCT CATGTGAGAC TATAATGGTG TrAGTGTGAT CATFAGGCAG TTAAAAACTG TrACAGGCTG GGCACGGTGG CTCATGCCTG TAATCCCAGC TCTCTGAGAG GCTGAGGTGG GCAGATCATC TGAGGTCAGG AG'ITCGAGAC CACCCATGGT CAACATGATG AAACCTCGTC TCTACTAAAA GTACAAAAAA FrAGCTGGAC ATGGTGGCAG GTGCCTGTAA TCCCAGCTAC TTGGGAGACT GAGACAGGAG AATrGCIGA GCCTGGGAGG CGGAGGT7GC ATrrGAGTCAA GATCGTGCCA 'ITGCACTCCA GCCTGGGCAA TAAGAGCGAT GCTCCGTCTC AAAAAA AAAAAAAAAA AAGAACTAT A=F~CAGAT TGTGTGGTTC C'=ACTAAC TGAA1TAAA TrAMIGTAG TCAAT1TAA ATGCTCTGT AT=AAAGC CACTGTACTC CAGCCTGGGT GACAGAGTGA WO 00/09525 PCT/US99/1 77-12 EPI-1 09 171 AACCCTAAT TCAAAAAAAA AAAAAAAAAA AAGAAAAGCT GGAATATI7GG CAAAATCAAG TAACTAAGAG AAAACATITAA ATTCACAGAA TACA FrA FA CA=fIAGAT ATATATGGTA TATGT1TCT CTGAAAAGCA CAAGCATACC T7flTG'I TAAATGGAGG GAACTAAAGA TACTMGGTG CCAAAATGAA ACATTA1TG TAATIAATCT CTrATrGAAA TGGGT1TCTA ACITJAG=T TGAATCGTAA TCTICAAAT TrCTTGTACT CATAGTCACT TGATGATrCT CTATCTGAAA TKTTCIAG AAM~GTrCT TGACCACCAG AAAAAGATTC AACTGTTACA TAGATGAAAA TGGATGTTGA GTGTrAACAG GCCTATGGGA AACAGTAT[r TCMFAGCTA CATTGTATTG T7GACTGTGT TGCTATITCTT ATAATGTI1A GGTCA'1AA A'I7T7fAGAA AGATCCAAGT ATTAAGATCT AGGGTGGCTA ACTITCACA GACAAAAAGC TTG=TGTAA GGTCAM1AC TATACCC 17A ATTCAGGAAG GT-rAGCT7GA ATTGGGTCAA AAGGAAACTG GTrAGAAAAT AAGTGAGTAG TGAATAGGCG ArrCAGTGCA AATTCCTTCC AGAAAATACC CT7GTAAATG ACTGTATGAA TGTGGAT7CT TCAAGACAGT CAAA ITATT GTGCGAAAGT AATACTITA TnII=GCAT CTCTAAAACA TGAACM~GA GTGA IT= AAAAAAA'rrG ATGCTAT'TAA ATAGA~rCAA ACCATAGAAA TGGAAAATAA ATITrCTGTTT GGGGCTITG GGGGGAITrAT GTrGTAAAAA TACC=rCT CTGTA=FTG TGC=AATTA GGTACAATrFG 'rrAAGCTAGA TGATAGCCTG TGGATGTrAC TAGTGCAAAA TCAAATTATC GTATTGTGTr F7CTCTGTAA AGTITGTCT TGTCI1TCT AGTGAT7CT CTrATTCCTG 'TrATFA=~ GAM GY1T TACAGACTGT GAAA'FrATTC GATGACATGA TGTATGAATT AACCAGTCAA GCCAGAGGAC TGTCAAGCCA AAA TTGGAA ATCCAGACCA CTCTAAGGAA TMTIACAA GTAAGTCAAA TGTATrAGAA AGGAGGAGAG AGAGGGAGCT TAAAGAATGT CAAAATTIT ATACTGATAC TGATITAGCTA TGTAT7CTA TGTAATGGCC TAATGTTGGA ATTAAATTTA TAGAATTAAA GACGTGAATA TAGAAACATG AATrCTGAAT AATAAACTCT TATAAGAAGA GAAGTCATCA AGCTAGCTGA CCCTACCTrGT ATITCAAGG ATATGTGTGG AACACCTGCC ATGTGTITG AAGTITGTGT TAGTATrCTA AATGGCTrAGA CAGT7GYTCC AGTATT7GTA GT7CTGATAG ACTAAAGTTC TGTGAAAAGA GGAAGAGACT GTG=T7F CA ITGCTGTA TrTGTAGCAC CCAGCATGCT GACTAATACC 'TITCAGTGC ACAAAAAATA TA FrCrAAGT GAAA ITCCT TCCTrATTCA CAGACAATGG TGCAGCTCTT AGGAGCrCTC ACAGGATGTG FrCAGCATAT CTGTGCCACA CAGGAATCCA TCA=I]GGA AAATATTCAG AGTCTCCCCT CCTCAGTCCT TCATATAATT AAAAGCACAT T7GTGCAT7G TAAGGTGAGT AAAGGTCTrAA FrATACFTG AATGGTATAT AATCAATGTG CATAGGGGCT GAGTAAAATA ATGT17GTAT AAGAT1TAC ATITAGTCT ATATTATTGA AATAAAC1T TCCATAGAAT AAAGAACATG TAAGTAAATA ATFGT7GCAA AAAAAGTGGT 'ITAAGGAAG TCATTAAAAG TGGCT'ITG GGGTITTA GTI=ATCTT A ITCCCCTC TATAAAGAAA GAAGTITAA GAATTGTGT TGAGACAGAC ACAGGGATCC TGAAATAG'FF ATGTCATGF GCATTGACCA ATA FrCAATT ACCATrATGA T]?AGATGTCA GAACTTCCTIT TrATAAAGGA AAGT7FAATCC TTA'IMAGTC CATCTCTACA TGCCAGAGGT AGCCTGAGG CACAAAAGCT TGCCTAGAAT 'FrATGGGTCA CAGACAG'IM TAATATrGCT A'ITGTTGGG CGAATGAAAA TCACTAGTFA ATrAATACCT CTCM~GCTG ATAGGATGCT AAAAATGTCA CGCACCTrGGC CTAATGTrAC CCflTITAG 7rCTGTAYT GCAAGATCAT GGAAGTCAGA AATAATATT17 TATACATGCT TGCATCTCTT GAAGCACACT ATA IMAATG GATGTTCACT AAACAATGAA TGAATATGTG ATFCAGTAAA MIIATGATCT CTAATAGTAT GAATrAAAGT AAAMIIGGCT CTTGAGCMT GATIT7GTII TTC TCTCATr 'ITAT1TATC CGTAATCAGA ATAGTGAATC TGTGTATrCT GGGTGT1TAC ACCTAGTI7C AGACCTCTC CAGGCTCTIT TCAAGGAGGC CrATrCTCrr CAAAAGCAGT TAATGGAACT GCTGGACATG GTITGCATGG ACCCMTAGT AGATGACAAT GATGATAMT TGAATATGGT AATAGGTGAG TGAAGAAAAC 'TrTCr A GTATATGGTG ACTATAAATC ATGTATCAAT TAAAATTGTC TCTrAATGA'rr CATGTTAT"I7 TCTTACTAAT TATGCATrAA AATTGA'TTFA AATCTACCA AATAAA=FT TAATC17GAA A ITTGGAATT TGTAAAAM11 ATI=GGGTA CCTTAACCTA GAM~GCGTA ITAGTTACT GTAAMTCTC CACAATGATT AACrrATATA AC=rATAAT CTCTGAGGT7 GTCCATAT7C AGAGACAATA ACM~CACAT ITTTAACC ATAACTGATA 'ITGAGATGCA G'1=TATATTr CCTTCCAGAA TACATATAAA TACGTGCATA TGTGTATGTA AATATGTCTA T7CTCATATA CATATTATAA TGAAATAACT CATITACAT GTGATGCACTr TTATACTAGT FA~TFAT M~A=FTAT TIT1TGAGA CAGAGTCTCA CTGTGTAGCC CAGGCTGGAG TGCAGTGGCA CAATCTCGGC TCACTrGCAAC CTCGCCTCCC GGACTCAAGC GAT-rCTCCTG CCTCAGCCTC ATGAGTAGCT GGGATrATAG GCGTCCGCCA CCACACCTrGG CTAATITIG TA'TI=AGT AGAGACAGGG T7CACCGTG TTGGCCAGGC TGGTCT7GAA CTCCTGACCT CAGGTAATCC ACCTFGCCTCA GCCTCCCAAA GTGCTGGGAT TACAGGCATG AGCCACCGTG CCCAGCCAAT ACTAG'IMAT FI=AAAGAA TTGCTrGGTCG TAACACAC F CATrGAITF ATCACTCATT AATGGAT7AT GAACAAGAGT TTGAAAAACA ATATAAAGGC AAAGMFGCA ITCAAAACTT TGGTATAAAG AGAGTAAGT GGTITGTGC AGTGTATCAG GCACCTGTrG CTCTGCAACA CACCACCTCA AAATCTA'Tr ATTCACTA'rr TA'F=ATTCA TGATTCTGTG AGTCTGCAGT TTAGGGTGGG ATGTCCTGAG ACAACI=CT CTGATCCACC TGGGGCACTA GCTCACCCAT GTGA=TCAG TGACTTCATT CACATCTGGC TGTTGGCAGA GGCAGAAGTA =TGAGAAAG CCATGTGCAT CATCCAGCAG GPTCACCCTA TCTCAGATAC CTGATGCCAG TGGTITCAGG GTwI'CTAAGA GTAGCAAAAG TGTGAGCAGG TCGCTrGTGTG CTAGCAC=r TCAAG'I1rCT GCTGCCTTA A=IrATrAT TGTCCCCCGG GCCACAGCAG GTCATAGCGT TTAGCCCAGA GTCAT7GTAG AAAAGTGTGG A FTCACAAAG GGCAGTCAT7 GTGGCCA IT T7ATAAATAA TCTACCACAG ACTGAGTAAA AGCCITGCAT GAATACCATG GATATrAATT TGAA'ITCTI7C CITITAGAT 'ITIcI=CCT TAGCAAIT7G TITGTCA17 T7GGATrAGA A FFATATCTG TAGAATATIT CAGUTATAAT AGGGTACAAC TITAT7CCA CTGAACATCT TrAGTPTAT TTAGGTCATC TGGTAGGTAT AAAM1CAGA AGT-rAATA IT CAATAITTrAT AAAAACCA77 AACAAGTGTG ACACTAAAT AG'TTAAATA ATTCITPGA CACAACTGTT TCCAAGTFGT G'FACGTATr FrAAT7CAAT CAAATGTTGA AATTGTrCAG TAGATAGMT TAA7TATAGG AGAAACTCAC CCCCATGACA TITGGATGTC T7AAAAGT7C TGTrATCMT CIMGCAGTr ATrCATITT TATrGGATAT CTGCTCTGT7 AMTCCAGTA TGGACCATGC AITI'CATGCC AATACITGGA AGTITATAAT TAAGTAAGT TG1TGTrAT T=TA=~- 'TrAGAAAATG TI=CCATAT TCCCCAATCT TAMT7AITCA TGATTCMTA GATTGCATTT7 AAAACAITI GTGTGAATIT AATGTTCACT GACACTGCTG TCTGATAATC CAGATATTCT ACATGTAGCT CTCAAGCCAA ATTGGA=TC TI17ACCCTGT GGCCTCTAAA ATTAAAAAAA ATGT7C1= CC TAGTTAGCTA GTACTTCAGA AATAATGGGC CATGGGCCAG ACTAGAAC'T7 AACCACTMT CITCTGCTAC TG FrG IAA CCAGCTATCA AGTATCCTAT TrCTAGGAT7 AGATAAAT7G ATAACTATAA 'rTAAAACTrGA ATATAATCTT TITCATrAGGT ACTITAAGT TGTrCACACT TAATrCCATT TGTACAGTAA TITAA=IT CIGAAACTGA AGCA'IIAA AGGGTCACCA GGGATAGTGC CTGTAGCATT CATCAGATrC TrAGGGGTGA GAGGAGATGT GG'FrGAGATG TAAAAATGGT TAAGAATATC TACITATAC ACATACATAA AACATTAAAG GTCAGTGTAT MTCAGGTCTr TAGGTACTIT7 T=~GTACTA CCAGGACATr AAGT7GCCAT TCAGTGGTTA AGAGTGTTGC CTGGGAGCTG TATCACATGT GCT7AAATCC AT1'CTrGAAA TCA=~ACTC C~rCTrGAGCC C TTGGGCTAT 'TGGTTAATr TCTCTGAACG Tr1AGMIGCT CATCTGAAAA TGGAAATAAT AATAGCAACT TCTTGACAGG GTTATAGTGA GAATrGAGTT CATCACTGTG AAATGCTwrAG AAATGTGCAT GACACATAGT TAATACTCAA GGAATTAGCC ACATCACTAT CATCATCACT GATTAT=TC CACTCTTACC CTCTCCAGT TCATITCTG CCCAGCAGAA TGATC'rTA AAAAGTAAAT CAGATCATGT TACTCTA'FrG CTTGAAGTCTr ATCCCAITT7G AYrAAGAATA ACAACCTAAT CCTCTGTGGA TGCTGCCTCC 'TTCACCAGCC TGTCTCATGC TGCTCTCCGT ACTCTTAGT7 CCTCAAACAT ACCAAACTCT CCTGTCCCAG AGTCTITCG TGGITI=CC ATCTGCCTAG GATGCTFCTC TCTCCTA=T TGTGTACCTT GCTAACTCCT GCTTACTGTC 1TCAGTTCT CAGCTFAAGA GYrATAT=T CATGATAACA TrCITIGATA TCCT7ACCCT AAGAYI'AAGT TAGATrGATA TC = ACCCT AAGAATAAGT TAGAITAGGT CTCTCTAT7G TAGCAC=~A GACTCTGTCA TTTGACAAAT CACAGCCCTA ATTAATTATr =TAAAATTA 'IMAACATTC TCTCTCATGC TAGACCACAA GITI7CATGCA GGTAAGGCGG AGATTGTGTC CA'TrGIMG ACCCCI=GT CTCCAGGGCC TGGTAGAATG CCTCATACAT AGTAAGAAITr CAATTFAATAT 'IMrACACAGA GAAAAAATrA GCAAC=ATT TAAACAAATA TAACTGC'FC AGAGGTAAAC TGGGCACATC TTAGTrATAT WO 00/09525 PCTIUS99/1 7712 EPI-109 172 TATGTGATAT ATGATGC T~fTGATTGT1T F=AAATGT TCTACAAGGT AGATATrG'Fr AGAGGTCCTA AGTTAC'ITGA TGTGTTACTT GTGGTGATTG TATrC1TFC Tl=rAFCA TPTAGcICAGA GCCTTAAGCA CCAGTCCATA ATAAAAAGCC AGTTGAAACA CAAAGATATA ATTACTAGCT TGTGTGAAGA CATTCTIMC TCCTCCATT C17T7TACA GTTAGCTGAG CAGATGACAC AGTCAGATGC ACAGGTAAAA TTGGGCTAA TAGCATITA AACAGCAACT C=A=ITCT 77GGCAGTrA GTAAATCTCA 'TrGAATGTC TGGGTCAGTC TAT17AAGAG GATITIAAT[ TATI1CA Tr GGGTGTfl =IIGATCTG TGGGATTAT7 TATATCCCAT AATTACT1T CACCCAGAGC ATTGTA FrAG AT]?CCTAACT GCTGTCATITG CCTCTGGGGT CTGCCTGGCT CCCT=rrGC YTGGTAACTG GTrGGTCACA GCA'rrC TTCT CAGAATCc= TCATTCT1T CTGCATGAGA ACAAAAA'ITC TI=GT7CAT ATrGTATAA GATCTGATAT AGC TGCAATC AATcrrGCAT TITCTTCA CCAACGCAfIr GCGACCMTA GGGATACAAG TATG=~GTG CATGTATATG TATGTATCAG TCTITAAAT flTGATATAGT CATACAMG TTT=AT1 GAAAAGTTAG AGTGUTGAAT TGGTATCCCA nI7ATGAAAC ATTATATrCT AAAAAMGT AGTACGAflA 'FrGGGAA~rA TAACTCATTT TCCTGTAACA C7GTrATACA TAGTACC'IM TGC'IMCAGA CTAGCCCTrCA ATITATTA ACTATAGTAG TCCTAAATrA TAAGATI'AAT AGTACTCAGG ACCTAACAGT TATATGTCAT FTGT1I-= ITITITGAG ATGGCGTCTC ACTCTGTCAC CCAAGCTGGA GTGCAGTGGT ATGACCTI'GG CTrCACTrGCAG Cc]7CTGCCTC ACGGG'ITCAA GGGATCGTTC TGCCT7AGCC TCCTGAGTAG CTGGGATrAT AGGCGCCTGC CACCACGCCT GGCTAMTI TTAGTAGAG ACGGGGTTTrC GCCATGTI'GG CCAGGCTGGT CTCGAACTCC TGACCTCAGG TGGTCCACCC GCCTGGCCT CCCAAAGTGC TGGGA FTACA GGTGTGAGCC ACCGCGCCCA GCCTATATGT AATAATT1A ATGGGACCAT GAATTGAATA TI7TrCCI17 GAATAGCAAT GACATAGCCC C~rCTA F7GT ACATCTGCAA GCTGATACAG GGAATTCCTr TGTACCTGCG CTCTrCCCTG CCAGTCAGCT ATGGGGGTGA AAGTGTAGGG GT'FCATCCAA GTCCTAAAAC TGGTAGCAAC TCCTAGGGCA GGGCTGATCT GGAAGGACAG ACCCTAGGGG AGGGTGGAAC TTrAAAAAGA AGTTCTGAAG GTAGTAAGAA GGAAATGAGG AGTAGTGTrA GGAAGGGGCT AACTITITC 'FrCTTGCTrC TC 1TCTIAT CTCACCTGCC CCTCCCCTrG TATCCC77CT TCCTITICC =TICC=TI TrGTCC TCAC TrCAFrCGTG CATCCTI1CT GATrCC TCTT ACC=GCTAA AAGGAGAAGT T7GMIGGGT ATCCTATATC AATGGCAGGA AGGT7GT1T CTTCT=ACC TTATCCTAT AGATTCATAT TCTCAACACC AACCTCCTCC 'FIT=CAG'IT TCCTTCTrGC FrCT=TGAC ACCACAGAGT Tr7GCAGCTAG TAC1TGGAGA GGAAAA FrAA ACAGAGATAC FrGGACCAAG AGTAAGATGA AGAAAGTCTA AACAACAGTA TAGTCTATAG TGGCAAGAGA GAGTATGGGG GCTGCTAGC CAGGGTGGCT GTACATAAAG TATATCTTCA GTrATATAA ACTGCTwrATA GATGGAAATC AGAAAAMFA AAT7CTCTTA ACTGTCCAAG AAAATTCTCA TFrTCAAA 'TrrGGGACTG ATAAATGTGA CCAGT7CTGC TTACTGTCCA TITGCCTGAAA TGGAGCM~G AGGTGGACTG TATAATFCT TCAATC~rAA CTCCAAA'FrC TGATCAGCGA CGCCCTrCTGC TG'FFCACTAT TAATAITAT FfACCAATCA AAGTAAAGTA TTGAAGTF CCTGGCAGT7 TTCACMrGT G'IIAGTCC A1TAGGCTG CTATAACAAA ATCCCTTAAA CTGGGTAAGG GATT1ATAAAT ATTAGAAArr TATCTCTCAC AGTrCTGGAA GCTGGGAAGC CCAATATCAA GGCACCAGTA GAM~GGTGT CTAACGAGGG TGTGCCGTCT G=TCAAAAA TGGCCC=TG TTGCTrGCATC CTCACTrAGT GCAAGGGGCA AGACAGCTCC CTCAACCTC =FTATAAGG GCACT7ATGT CA'ITCATGAG GGCAGAGCCC TCATGACTTA ATCA=TCCC CAAAGGCCCC ACCrCT-rAAT AGTATCACAT TGGGTGTTAG GTGTCTGGGA GGACACCAAT C~TrCAAGCCA TATCATCTrCA C~rGGAAAAA AGTCAAAATA AAACCAGTAG AMfAA TTAA TAT7ACACTA TTrATAGAAG CATGTGATGT ATCATrCCT GTA'ITAATIT CCTGGGGTFG CCGTAACAAG T7ACCACAAA CTAGGTGGCT TAAAACAATA GAAT1TATr CTCTCACA'rr TCTAGAGGCA GAAG'1rCACA GTGTGTCAAT AGGGCCATGT TCTCTGGAAG GCM~AGGGG AGAATATATI' TCATATCMT CTCTAGCTT CTCGGTGTCA CTGGCAATCC TTAG=TACT TrGGC'IMCT GTGTCTTCAC ATCATC1Th TATAAGAACA CCAGTGATAG TGATrAAGGG CATACCITrAC TTFAATATGA CCTCAT=~A ACTAA'ITATG TCTrCAATAA CCCTATCC AAATAAGGCC ACATTrTGAA GTATTGGGAG TTrAGAACTrA AAGC1TITG GGAGGGACAC AGTFCAACCC ATAACAACCC CTAAAATCGA TAM~A'TCr CAA'I1AAGTC TTGAAATTGG TI7CAAAAAG AGAATATTCT ATrAGAGTT17 TTAATGTATA GTITAACAT ATAG'ITCMT AGCCCCCAAT FIrflTITI TITITITI 'TITITrlTI TITIGAGAC GGAGTCTCGC TCTGTCGCCC AGGCCGGACT GCGGACTGCA GTGGCGCAAT CTrCGGCTCAC TGCAAGCTCC GCTTCCCGGG TrCACGCCAT TCCCCTGCCTr CAGCCTCCCG AGTAGCTGGG ACTACAGGCG CCTGCCACCG CGCCCGGCTA A'TIr=GT A'TTMAGTA GAGACGGGGT TrrCAC=~GT TAGCCAGGAT GGTCTCGATC TCCTGACCTrC ATGATCCACC CGCCTCGGCC TCCCAAAGTG CTGGGATTAC AGGCGTGAGC CACCGCGCCC GGCCTGCCCC CAA FIA'IT[A G 'IT1CTAT AAACAGGGAA ATTAMJGT GTGGCCC'T7A GAACTAA'ITr AA'TrCCACT CTAATTCCTA CTTATG1TA TATAATGCTr T7AGAAAMT GTATTATTCA GAAAATAAAC ATATACTATT GTATCTGTTG CCTACACTA GATITAT7G CCTGCTATAT TTAAA'IIA TTAGTATIT AAT-fGTIA 'ITAAAGAAAG AATGTGCCTG TAATCTCAGC AC=TGAGA GGCCAAGGCA GAAGGAT'rGC T7GAGCCCAG GAGTIGAGA CCAGACTGAG CAACACAGGG AGACCCCCAT CTCTACAAAA AATAAAAAAA TI'CTCCAGGC CTCATGGCAC ATACCTGTAG 'rrCTAGT-TAC 'PTGGGAGACT GGGGTGGGAG GATGCATTGA GCCCAGGAGA TTGAGGCTGC AGTGAGCCAT GATCAGGCCA CTGTACTCCA GCTGGACAA CAGAGTGAGA GCTGTCTAG ATAGATAGAT AGATAGATAA TCTAAATAGA TAATAGACAG ATX'ATCTAAA TAGATAATAG ACAGATTATC TAAATAGATA ATAGACAGAT TATCTAAATA GATAATAGAC AGATrATCTA AATAGATAAT AGACAGATTA TCTAAATAGA TAATAGACAG ATTATCTATC TAAATAGATA ATAGA'ITATC TAAATAGATA ATAGATAGAT AGATrAGATA GATAGATAGA TAGATAGAGC TTGGACAACA GAGTGAGAGC CTGTCTAGAT AGATAGAAAC AAAGAAAGAA AGAAAGAATG GTGCTCATAT TITAAAGCAT TGAAAAATGG TC'TCTTGC TFrATArrACC CACACCTTrCT Tr7GTrGG CAT TAAGATGCAA ACIT1GTI AAACAGT7GA GTAAATCAAA GATGGGACTG TrAAGT7A'Tr TGTGTrA'ITT ACCTGC1T TGAAAATGTA AAAATAAAAC TCTAGG'ITA ATTAGTAGTA TGCTATT7AG TAATGAAGTA AAGCTAGAGG C'ICGAACAA ATCTTGTGTA AT 1TCCTCT GAATGAGAGA GAAAA'TrAA AGTAAGCAAA CAAATAAGTr GTGTGTCACC ACTCATCAG TCAnI7AACA AGTA'ITCCA GAGTAC'IAT TCTGTGCCAG GAAATGT7GT AGGTGCCCTC AACAACTTAG AGTCTAGCCTr GAGACACAAG TAAGTAGGTA ATrATlATAG AATGGTATGA TCMTGGAGG ACTGGGTATr GGCTGGCTCA TGGGAGTACA AGATAGGTAC CCAGTGATGA AGTCAGGAAA GGTI7T11AT GGTGATATGA TGACGTCTAT GC~rGATTATA AGGTCAGTGT AGAATAAACT TrGTGCTIT AAAT1GCAT AGCACTGTAT TAGAGAG'rTC ATCTrCAAAA TAATCGAAAA GGCTGAGTGT GGTGACCCAT GGCTGTAATC CCAGCACMT GGGAGGCCGA GGTGGGCAGA T7GCTrGAGC TAGGAGTTCG AGACCAGGCT GGCCAACATG GTGAAACCCC GTCTCTACTA AAAATACAAA AATTAGCCAG GAGTGATGGT GCGCACCTGT AATGCCAGCT ACTTGGGAGG CTGAGGCAGG AGGATCACTT GAACCCAGGA GGTGGAGGTr GAAGTAAGCC GAGGTCATGC CACTGCACTC CAGCCTGGGC AACAGAGTGA GACTCCATCT CAAAAAAAAA AAAAATGATC AAAGAAAGGT GAA=IICAT CTACCCTATr TCTGCTGAGG AAAATGGACT A=ICAAAT AT1TAATA AGGGTCAAAA tGAGGGATC-3' (FRAG. NO: _) (SEQ. ID NO: 2480) 5'-CCTGAGACAG AGGCAGCAGT GATACCCACC TGAGAGATCC TGTG'1GAA CAACTGCrrC CCAAAACGGA AAGTNTrCA AGCCTAAACC M~GGGTGAA AAGAACTC= GAAGTCATGA TTG=TCACA GTrrcTCTCA GCTCTCACTT TGGTG=CT~ CA'TrAAAGAG AGTGGAGCCT GGTC=ACAA CACCTCCACG GAAGCTFATGA CTATGATGA GGCCAGTGCT TATTGTCAGC AAAGGTACAC ACACCTGGTT GCAATTCAAA ACAAAGAAGA GAT7GAGTAC CTAAACTCCA TA'ITGAGCTA TTCACCAAGT TATTACTrGGA 7rGGAATCAG AAAAGTCAAC AATGTGTGGG TCTGGGTAGG AACCCAGAAA CCTCTGACAG AAGAAGCCAA GAACTGGGCT CCAGGTGAAC CCAACAATAG GCAAAAAGAT GAGGACTGCG TGGAGATCTA CATCAAGAGA GAAAAAGATG TGGGCATGTG GAATGATGAG AGGTGCAGCA AGAAGAAGCT TGCCCTATGC TACACAGCTG CCTGTACCAA TACATCCTrGC AGTGGCCACG GTGAATGTGT AGAGACCATC AATAATrACA CTGCAAGTG TGACCCTGGC TrCAGTGGAC WO 00/09525 PCT/US99/17712 EPI-109 173 TCAAGTGTGA GCAAATTGTG AACTGTACAG CCCTGGAATC CCCTGAGCAT GGAAGCCTGG TTTGCAGTCA CCCACTGGGA AACTTCAGCT ACAATTCTTC CTGCTCTATC AGCTGTGATA GGGGTTACCT GCCAAGCAGC ATGGAGACCA TGCAGTGTAT GTCCTCTGGA GAATGGAGTG CTCCTATTCC AGCCTGCAAT GTGGTTGAGT GTGATGCTGT GACAAATCCA GCCAATGGGT TCGTGGAATG TTTCCAAAAC CCTGGAAGCT TCCCATGGAA CACAACCTGT ACATTGACT GTGAAGAAGG AMGAACTA ATGGGAGCCC AGAGCCTTCA GTGTACCTCA TCTGGGAATT GGGACAACGA GAAGCCAACG TGTAAAGCTG TGACATGCAG GGCCGTCCGC CAGCCTCAGA ATGGCTCTGT GAGGTGCAGC CATTCCCCTG CTGGAGAGT'T CACCTTCAAA TCATCCTGCA ACTTCACCTG TGAGGAAGGC TTCATGTTGC AGGGACCAGC CCAGGTTGAA TGCACCACTC AAGGGCAGTG GACACAGCAA ATCCCAG'T GTGAAGCTT CCAGTGCACA GCCTTGTCCA ACCCCGAGCG AGGCTACATG AATTGTCTTC CTAGTGCTTC TGGCAGTTC CGTTATGGGT CCAGCTGTGA GTTCTCCTGT GAGCAGGGTT TTGTGTTGAA GGGATCCAAA AGGCTCCAAT GTGGCCCCAC AGGGGAGTGG GACAACGAGA AGCCCACATG TGAAGCTGTG AGATGCGATG CTGTCCACCA GCCCCCGAAG GGTTTGGTGA GGTGTGCTCA TTCCCCTATT GGAGAATTCA CCTACAAGTC CTCTTGTGCC TTCAGCTGTG AGGAGGGATT TGAATTATAT GGATCAACTC AACTTGAGTG CACATCTCAG GGACAATGGA CAGAAGAGGT TCCTTCCTGC CAAGTGGTAA AATGTTCAAG CCTGGCAGTT CCGGGAAAGA TCAACATGAG CTGCAGTGGG GAGCCCGTGT TTGGCACTGT GTGCAAGTrC GCCTGTCCTG AAGGATGGAC GCTCAATGGC TCTGCAGCTC GGACATGTGG AGCCACAGGA CACTGGTCTG GCCTGCTACC TACCTGTGAA GCTCCCACTG AGTCCAACAT TCCCTTGGTA GCTGGACM CTGCTGCTGG ACTCTCCCTC CTGACATTAG CACCATTTCT CCTCTGGCTT CGGAAATGCT TACGGAAAGC AAAGAAATIT GTTCCTGCCA GCAGCTGCCA AAGCCTTGAA TCAGACGGAA GCTACCAAAA GCCTCTTAC ATCCTAAG TTCAAAAGAA TCAGAAACAG GTGCATCTGG GGAACTAGAG GGATACACTG AAGTTAACAG AGACAGATAA CTCTCCTCGG GTCTCTGGCC CTTCGCCT ACTATGCCAG ATGCCTTTAT GGCTGAAACC GCAACACCCA TCACCACTrC AATAGATCAA AGTCCAGCAG GCAAGGACGG CCTCAACTG AAAAGACTCA GTGTTCCCTT TCCTACTCTC AGGATCAAGA AAGTGTTGGC TAATGAAGGG AAAGGATATT TTCTCCAAG CAAAGGTGAA GAGACCAAGA CTCTGAAATC TCAGAATTCC TTCTAACT CTCCCTTGCT CGCTGTAAAA TCTTGGCACA GAAACACAAT ATITTGTGGC T'TTC1TTC TTGCCCITCA CAGTGTTCG ACAGCTGATT ACACAGTTGC TGTCATAAGA ATGAATAATA ATTATCCAGA GTTTAGAGGA AAAAAATGAC TAAAAATATT ATAACTAAA AAAATGACAG ATGTTGAATG CCCACAGGCA AATGCATGGA GGGTTGTTAA TGGTGCAAAT CCTACTGAAT GCTCTGTGCG AGGGTTACTA TGCACAATTT AATCACTTTC ATCCCTATGG GATTCAGTGC TTCTTAAAGA GTTCTTAAGG ATTGTGATAT 'TTACTTGC ATTGAATATA TTATAATCTT CCATACTCT TCATCAATA CAAGTGTGGT AGGGACTTAA AAAACTTGTA AATGCTGTCA ACTATGATAT GGTAAAAGTT ACTATCTA GATTACCCCC TCATTGTTTA TTAACAAATT ATGTTACATC TG1111AAAT TTATTTCAAA AAGGGAAACT ATTGTCCCCT AGCAAGGCAT GATGTTAACC AGAATAAAGT TCTGAGTGT TTTACTACAG TTGiT1G AAAACATGGT AGAATTGGAG AGTAAAAACT GAATGGAAGG 'FTGTATATT GTCAGATAT TITTCAGAAA TATGTGGTTT CCACGATGAA AAAC'TCCAT GAGGCCAAAC GTITTGAACT AATAAAAGCA TAAATGCAAA CACACAAAGG TATAATITTA TGAATGTCTT TGTTGGAAAA GAATACAGAA AGATGGATGT GCTTTGCATT CCTACAAAGA TGTTGTCAG ATGTGATATG TAAACATAAT TC7TGTATAT TATGGAAGAT TTTAAATTCA CAATAGAAAC TCACCATGTA AAAGAGTCAT CTGGTAGATT 'TTAACGAAT GAAGATGTCT AATAGTrAT CCCTATTTGT TTTCTCTGT ATGTTAGGGT GCTCTGGAAG AGAGGAATGC CTGTGTGAGC AAGCAMTTAT GMATTTAT AAGCAGATIT AACAATTCCA AAGGAATCTC CAGTTTTCAG TTGATCACTG GCAATGAAAA ATTCTCAGTC AGTAATTGCC AAAGCTGCTC TAGCCT7GAG GAGTGTGAGA ATCAAAACTC TCCTACACT CCATrAACT AGCATGTGTT GAAAAAAAAA GTTTCAGAGA AGTTCTGGCT GAACACTGGC AACGACAAAG CCAACAGTCA AAACAGAGAT GTGATAAGGA TCAGAACAGC AGAGGTTCTT TTAAAGGGGC AGAAAAACTC TGGGAAATAA GAGAGAACAA CTACTGTGAT CAGGCTATGT ATGGAATACA GTGTTA1111 CTGAAATT GTITAAGTGT TGTAAATATT TATGTAAACT GCATFAGAAA TTAGCTGTGT GAAATACCAG TGTGGTTTGT GTFTGAGTIT TATTGAGAAT TITAAATTAT AACTTAAAAT ATTTTATAAT TITTAAAGTA TATATIT7A TAAGCTTATG TCAGACCTAT TTGACATAAC ACTATAAAGG TTGACAATAA ATGTGCTAT GTTT-3' (FRAG. NO: ___) (SEQ. ID NO: 2479) 5'-CCT TGC CTG CTG G-3' (FRAG. NO: 1739) (SEQ. ID NO: 1750) 5'-GTT GTC CC-3' (FRAG. NO: 1740) (SEQ. ID NO:1751) 5'-GTF CT GGC TTC TTC TGT C-3' (FRAG. NO:1080) (SEQ. ID NO:1090) 5'-GGC TGG TGG-3' (FRAG. NO:1083) (SEQ. ID NO:1093) 5'-CGT TGG CT CTC GTT GTC CC-3' (FRAG. NO:1081) (SEQ. ID NO:1091) 5'-TGT GGG CT CTC GTT GTC CC-3' (FRAG. NO:1082) (SEQ. ID NO:1092) 5'-CCC TTC GGG GGC TGG TGG-3' (FRAG. NO:1083) (SEQ. ID NO:1093) 5'-GGC CGT CCT TGC CTG CTG G-3' (FRAG. NO:1084) (SEQ. ID NO:1094) Human P Selectin Fragments 5'-T'IT TCT CIT TCG CTU TCT TTT CGT CTC CTG TTC CTC CIT TT 'FG CTG TTT TTT CTC CTT CTT CTC TCC TIT CU TTC-3' (FRAG. NO: 1741) (SEQ. ID NO: 1752) 5'-TCC TIT CTT TTC-3' (FRAG. NO: 1742) (SEQ. ID NO: 1753) 5'-CTC CIT T-3' (FRAG. NO:1743) (SEQ. ID NO:1754) 5'-TIT TCT CTT TCG CIT TCT' TT CGT CTC CTG TTC CTC CT TT-3' (FRAG. NO:1085) (SEQ. ID NO:1095) 5'-TTG CTG TTT TIT CTC CT CTT CTC TCC TFT CT TTC-3' (FRAG. NO:1086) (SEQ. ID NO:1096) Human Endothelial Monocvte Activating Factor Nucleic Acid and Antisense Oligonucleotide Fragments 5'-TTT TCT CTT TCG CTT TCT TIT CGT CTC CTG TTC CTC CTU TT TTG CTG T'T TTT CTC CTT C CTC TCC TTT CTT TC-3' (FRAG. NO: 1744) (SEQ. ID NO: 1755) 5' -CC TT CT TTC FRAGG. NO: 1745) (SEQ. ID NO: 1756) 5'-CTG TC CTC CU TT-3' (FRAG. NO:1746) (SEQ. ID NO:1757) 5'-TTT TCE CU TCG CTU TCT TT CGT CTC CTG TTC CTC CTU T-3' (FRAG. NO:1087) (SEQ. ID NO:1097) 5'-TTG CTG TTT TTT CTC CTU C CTC TCC TFT CUr TTC-3' (FRAG. NO:1088) (SEQ. ID NO:1098) Human IL3* Nucleic Acid and Antisense Oligonucleotide Fragments 5-CTC TGT CUT GTU CTG GTC CU CGT GGG GCT CEG TGT CGC GTG G GTG CGG CCG TGG CC GGC GGB CCB GGB GTT GGB GCB GGB GCB GGB CGG GCB GGC GGC TCB TGT TTG GBT CGG CBG GBG GCB CTC (FRAG. NO: 1747) (SEQ. ID NO: 1758) 5-G GBG GCB CTC-3' (FRAG. NO: 1748) (SEQ. ID NO: 1759) WO 00/09525 PCTIUS99/17712 EPI-109 174 5'-GT GGG GCT CTG-3' (FRAG. NO:1749) (SEQ. ID NO:1760) HUMIL3AAS1: 5'-CTC TGT CTT GTT CTG GTC CTT CGT GGG GCT CTG-3' (FRAG. NO:1089) (SEQ. ID NO:1099) HUMIL3AAS2: 5'-TGT CGC GTG G GTG CGG CCG TGG CC-3' (FRAG. NO:1090) (SEQ. ID NO:1100) GGC GGB CCB GGB GT' GGB GCB GGB GCB GGB CGG GCB GGC GGC TCB TGT TTG GBT CGG CBG GBG GCB CT.C (FRAG. NO:1091) (SEQ. ID NO:1101) Human IL3 Receptor Nucleic Acid and Antisense Oligonucleotide Fragments 5'-TCT GGG GTG TCC TGG CCT TCG TGG TTC CTC TTC CTT CGT TTG CCG TCC GCG GGG GCC CCC GGG CCT GGC TGC GCT CCT GCC CCG CCT CTT TCC CGG GCT CTT GCG CTG GGG GGT GCT CC CGT GTG TTT GCG CCC TC CTC CTG GTC GCG CTT GTC GTT TTG GGG CCG GCT TTG CCC GCC TCC CGG CGC CTG GCC CGG CC TITC CTG GGC TGC GTG CGC GTT CTG TTC TTC TTC CTG GCT CTG GGG TGT CCT GGC CTT CGT GGT TCC TCT TCC TTC GTT TGC CGT CCG CGG GGG CCC CCG GGC CT GGC TGC GCT CCT GCC CCG CCT CTr TCC CGG GCT CTT GCG CTG GGG GGT GCT CCC GTG TGT TG CGC CCT CCT CCT GGT CGC GCT TGT CGT TTT GG GGC CGG CTT TGC CCG CCT CCC GGC GCC TGG CCC GGC CTT CCT GGG CTG CGT GCG CGT TCT GTT CTT CTT CCT GGC GCA GGA GAC AGG GCA GGG CGA TCA GGA GCA GCG TGA GCC AAA GGA GGA CCA TCG GGA ACG CAG CTC CGG AAC GCA GGA CAG AGG TGC C GC BGG BGB CBG GGC BGG GCG BTC BGG BGC BGC GTG BGC CBB BGG BGG BCC BTC GGG BBC GCB GCT CCG GBB CGC BGG BCB GBG GTG CC-3' (FRAG. NO: 1750) (SEQ. ID NO: 1761) GBG GTG CC-3' (FRAG. NO: 1751) (SEQ. ID NO: 1762) 5'- GCC CCG C-3' (FRAG. NO:1752) (SEQ. ID NO:1763) 5'-TCTGGGGTGTCCTG (FRAG. NO:1092) (SEQ. ID NO:1102) 5'-GCCTTCGTGGTTCC (FRAG. NO:1093) (SEQ. ID NO:1103) 5'-TCTTCCTTCGTTGC (FRAG. NO:1094) (SEQ. ID NO:1104) 5'-CGTCCGCGGGGGCCCCCGGGCCT (FRAG. NO:1095) (SEQ. ID NO:1105) 5'-GGC TGC GCT CCT GCC CCG C (FRAG. NO:1096) (SEQ. ID NO:1106) 5'-CTCTTTCCCGGGCTCTT (FRAG. NO:1097) (SEQ. ID NO:1107) 5'-GCGCTGGGGGGTGCTCC (FRAG. NO:1098) (SEQ. ID NO:1108) 5-CGTGTGTTTGCGCCCTCCTCCTGGTCGC (FRAG. NO:1099) (SEQ. ID NO:1109) 5'-GCTTGTCGTTTGG (FRAG. NO:1100) (SEQ. ID NO:1110) 5'-GGCCGGCTTTGCCCGCCTCCC (FRAG. NO:1101) (SEQ. ID NO:1111) 5'-GGCGCCTGGCCCGGCC (FRAG. NO:1102) (SEQ. ID NO:1112) 5'-TTCCTGGGCTGCGTGCGC (FRAG. NO:1103) (SEQ. ID NO:1113) 5'-GTCTGTTCTTCTTCCTGGC (FRAG. NO:1104) (SEQ. ID NO:1114) 5'-GCB GGB GBC BGG GCB GGG CGB TCB GGB GCB GCG TGB GCC BBB GGB GGB CCB TCG GGB BCG CBG CTC CGG BBC GCB GGB 5'-CBG BGG TGC C (FRAG. NO:1105) (SEQ. ID NO:1115) Human IL-4 Nucleic Acid and Antisense Oligonucleotide Fragments 5'-CTC TGG TTG GCT TCC TTC GCC GGC BCB TGC TBG CBG GBB GBB CBG BGG GGG BBG CBG TTG GGB GGT GBG BCC CBT TBB TBG GTG TCG B-3' (FRAG. NO: 1753) (SEQ. ID NO: 1764) 5'-GCC GGC BCB-3' (FRAG. NO: 1754) (SEQ. ID NO: 1765) 5'-T TCC TTC-3' (FRAG. NO:1755) (SEQ. ID NO:1766) 5'-CTC TGG TG GCT TCC TTC-3' (FRAG. NO:1106) (SEQ. ID NO:1116) 5'-GCCGGCBCBTGCTBGCBGGBBGBBCBGBGGGGGBBGCBGTTGGGBGGTGBGBCCCBTTBBTBGGTGTCGB-3' (FRAG. NO:1107) (SEQ. ID NO:1117) Human IL4 Receptor Nucleic Acid and Antisense Oligonucleotide Fragment 5'-TCT GCC CTG TCC GCC GGC TCT TCG GTG GCT CGG CCC CGC TCC TTG TCT TGC CGC GGG TTG GTT CCT GGG CCT GGT TCT TGC GGG CGT TTC GGT CTG CTG GCT GGT CTG GGC CCG CGG TGC GOC GGG TGG CTT GCT GTT CTG CCT GGG CTC TCC CCT CTC CTC CIT TTC TCC CTr CCT CTG TCT TGC CTC CTT CCT CTG GGT CCT CTT GGC CTG GGC GCT CTT CCC CTC GGG CGG CTG CGG GCG CTC GTG CTG CCT GGT CCG CTC CCT GGG GGT GCT CCT TCC CIT TCC CCG CTC GTG GGG TTT GCG GGG CTG GGC TGC CCT GGG GGG TCT GGG CCT TT GGG GTC GGC TGG CTG CTO CTT CGG GCC GCC TGG GCT TCC CTG TGC CCC TTT CCT CTG CTG GGT CCC CCT CCC GTT CCA AGC TGC ACC GCA CAG ACC GGC GCT ACA GGA CAG AGC CAG GCA AGC ACC CAT GGG GAT CCA GGC CCA GCT GTT CCB BGC TGC BCC GCB CBG BCC GGC GCT BCB GGB CBG BGC CBG GCB BGC BCC CBT GGG GBT CCB GGC CCB GCT G -3' (FRAG. NO: 1756) (SEQ ID NO: 1767) 5'-TCTGCGC-3' (FRAG. NO: 1757) (SEQ ID NO: 1768) 5'-CCT GCT CCT GGGG (FRAG. NO:1758) (SEQ. ID NO:1769) 5'-TCTGCGCGCCCCTGCTCC (FRAG. NO:1108) (SEQ. ID NO:1118) 5'-CGCCCGGCTTCTCT FRAGG. NO:1109) (SEQ. ID NO:1119) 5'-CGTGTGGGCTTCGG (FRAG. NO:1110) (SEQ. ID NO:1120) 5'-CCCCGCGCCTCCGTTGTTCTC FRAGG. NO:1111) (SEQ. ID NO:1121) 5'-TGCTCGCTGGGCTG (FRAG. NO:1112) (SEQ. ID NO:1122) 5'-GGTTCCTGGGGCCCTGGGTTTC (FRAG. NO:1113) (SEQ. ID NO:1123) 5'-TCTGCCGGGTCGTITTC (FRAG. NO:1114) (SEQ. ID NO:1124) 5'-GGGTGCTGGCTGCG (FRAG. NO:1115) (SEQ. ID NO:1125) 5'-CTTGGTGCTGGGGCTCC (FRAG. NO:1116) (SEQ. ID NO:1126) 5'-GGCGGCTGCGGGCTGGGTTGGG (FRAG. NO:1117) (SEQ. ID NO:1127) 5'-CTTGGCTGGTTCCTGGCCTCGGG (FRAG. NO:1118) (SEQ. ID NO:1128) 5'-CCTCCTCCTCCTCCTCGCTCCmlTrClTCCTCT FRAGG. NO:1119) (SEQ. ID NO:1129) 5'-TCCCTGCTGCTCTC (FRAG. NO:1120) (SEQ. ID NO:1130) 5'-TGCCCTCCCTTCCCTCCTGG (FRAG. NO:1121) (SEQ. ID NO:1131) 5'-GGTGCCTCCTTGGGCCCTGC (FRAG. NO:1122) (SEQ. ID NO:1132) 5-GGCTGCTCCTTGCCCC (FRAG. NO:1123) (SEQ. ID NO:1133) WO 00/09525 PCTIUS99/17712 EPI-109 175 5'-CTCTGGGTCGGGCTGGC (FRAG. NO:1124) (SEQ. ID NO:1134) 5'-GGGGCGTCTCTGTGC (FRAG. NO:1125) (SEQ. ID NO:1135) 5'-CTGGCCTGGGTGCC (FRAG. NO:1126) (SEQ. ID NO:1136) 5'-GCCTCTCCTGGGGGGGTGGCTCCCTGTCC (FRAG. NO:1127) (SEQ. ID NO:1137) 5'-CCTITTICCCCCGGCTCC (FRAG. NO:1128) (SEQ. ID NO:1138) 5'-GTGGGGGCTTTGGC (FRAG. NO:1129) (SEQ. ID NO:1139) 5'-GGG GGT CTG TGG CCT GCT CCT GGG G (FRAG. NO:1130) (SEQ. ID NO:1140) 5'-AGGGGTCTGGGGCCCTC (FRAG. NO:1131) (SEQ. ID NO:1141) 5'-TTTTGGGGGTCTGGCTTG (FRAG. NO:1132) (SEQ. ID NO:1142) 5'-GCCTGGCTGCCTTCC (FRAG. NO:1133) (SEQ. ID NO:1143) 5'-GGGGCCTGCCGTGGGGC (FRAG. NO:1134) (SEQ. ID NO:1144) 5'-TGTCCTCTGTTGCTCCCCTT (FRAG. NO:1135) (SEQ. ID NO:1145) 5'-TGCCTGCTGTCTGG (FRAG. NO:1136) (SEQ. ID NO:1146) 5'-GGTrCCCGCCTTCCCT (FRAG. NO:1137) (SEQ. ID NO:1147) 5'-GTT CCC AGA GCT TGC CAC CTG CAG CAG GAC CAG GCA GCT CAC AGG GAA CAG GAG CCC AGA GCA AAG CCA CCC CAT TGG GAG ATG CCA AGG CAC CAG GCT G (FRAG. NO:1138) (SEQ. ID NO:1148) 5'-GTT CCC BGB GCT TGC CBC CTG CBG CBG GBC CBG GCB GCT CBC BGG GBB CBG GBG CCC BGB GCB BBG CCB CCC CBT TGG GBG BTG CCB BGG CBC CBG GCT G-3' (FRAG. NO:1139) (SEQ. ID NO:1149) Human IL5* Nucleic Acid and Antisense Oligonucleotide Fragments 5'-TCCCTGTTTC CCCCCTTTCG TTCTGCGTTT GCCTTTGGCG -11TPTGTTT GTTTTCTCTC TCCGTCTTTC TTCTCCCCT GTGGGBBTTT CTGTGGGGBT GGCBTBCBCG TBGGCBGCTC CBBGBGCTBG CBBBCTCBBB TGCBGBBGCB TCCTCBTGGC TCTGBBBCGG TGGGAATTrC TGTGGGGBTG GCATACACGT AGGCAGCTCC AAGAGCTAGC AAACTCAAAT GCAGAAGCATC CTCATGGCTC TGAAACG-3' (FRAG. NO: 1759) (SEQ. ID NO: 1770) 5'-GCC CCG GG-3' (FRAG. NO: 1760) (SEQ. ID NO: 1771) 5'-G GGT TTC T-3' (FRAG. NO: 1761) (SEQ. ID NO: 1772) 5'-GTG GGG BTG GC-3' (FRAG. NO: 1762) (SEQ. ID NO:1773) 5'-CCB BGB GCT BGC-3' (FRAG. NO: 1763) (SEQ. ID NO: 1774) 5'-TCC CTG TTT CCC CCC TTT-3' (FRAG. NO:1140) (SEQ. ID NO:1150) 5'-CGT TCT GCG TTT GCC TT GGC-3' (FRAG. NO:1141)(SEQ. ID NO:1151) 5'-GTT TT TGT TTG TT TCT-3' (FRAG. NO:1142)(SEQ. ID NO:1152) 5'-CTC TCC GTC TT CTT CTC C-3' (FRAG. NO:1143) (SEQ. ID NO:1153) 5'-CCT CCT GCC TGT GTC CCT GCT CCC C-3' (FRAG. NO:1144) (SEQ. ID NO:1154) 5'-GAG GGT TTC TGG CiT CCT CTC T-3 (FRAG. NO:1145) (SEQ. ID NO:1155) 5'-TGT CTC TCT GTC CTT TTG TT-3' (FRAG. NO:1146) (SEQ. ID NO:1156) 5'-TGT TGT GCG GCC TGG TGC TGC CCT GCC CCG GG-3' (FRAG. NO:1147) (SEQ. ID NO:1157) 5'-GTG GGA ATT TCT GTG GGG BTG GCA TAC ACG TAG GCA GCT CCA AGA GCT AGC AAA CTC AAA TGC AGA AGC ATC CTC ATG GCT CTG AAA CG-3' (FRAG. NO: 1764) (SEQ. ID NO: 1775) 5'-GTG GGB BTT TCT GTG GGG BTG GCB TBC BCG TBG GCB GCT CCB BGB GCT BGC BBB CTC BBB TGC BGB BGC BTC CTC BTG GCT CTG BBB CG-3' (FRAG. NO:1148) (SEQ. ID NO:1158) Human IL-5 Receptor Nucleic Acid and Antisense Oligonucleotide Fragments 5'-CTCAGTGGCC CCCAAAAGGA TGAGTAATAC ATGCGCCACG ATGATCATAT CCITT1ACT ATGAGGCCGT GTCTGTCGTG TCTITCCTTT GCTCTTGGTG TGTCTTTGCT GTGCCCTGCC TCTCTGCCCG TGTCTGTCGT GTCTTTCCTT TGCTCTTGGT GTGTCTTTGC TGTGCCCTGC CTCTCTGCC CGTGTCTGTC GTGTCTTTCC TTTGCTCTTG GTGTGTCTTT GCTGTGCCCT GCCTCTCTGC-3' (FRAG. NO: 1765) (SEQ. ID NO: 1776) 5'-CCG TGT C-3' (FRAG. NO: 1766) (SEQ. ID NO: 1777) 5'-GCCCTGCC-3' (FRAG. NO: 1767) (SEQ. ID NO: 1778) 5'-CCG TGT CTG TCG TGT CT-3' (FRAG. NO:1149) (SEQ. ID NO:1159) 5'-TCCITGCTCTrG-3' (FRAG. NO:1150) (SEQ. ID NO:1160) 5'-GTGTGTCTTTGCTGT-3' (FRAG. NO:1151) (SEQ. ID NO:1161) 5'-GCCCTGCCTCTCTGC-3' (FRAG. NO:1152) (SEQ. ID NO:1162) 5'-CT CBGTGGCCCC CBBBBGGBTG BGTBBTBCBT GCGCCBCGBT GBTCBTBTCC TITTBCTBT GBGG (FRAG. NO: 1768) (SEQ. ID NO: 1779) Human IL-6 Receptor Fragments 5'-GGGGGTGGCT TCCrGCCGCG TCTCTGGGCC GTCCCGTCCC TCGGCCCCGC GCCGCGCTCG GCTCCTCTCC CTCTGGCCCG GCTCGGGGCG GGGCGGGGCG GTGGGCGGGC GGCGCTGCCC TGCGCGCGGC GCTGGCCCCT GCTGGCCGTC GGCTGCGCGC TGCTGGCTGC CCTGCTGGCC GCGCCGGGGC CTGTCCGCCT CTGCGGGCGC TGTCTCCTGG CTTGTCTTCC GGCTCTTCTG CTGGGGTGGG GCTGGGCGGC CGGCCCGGTG CTGGGGCTCC TCGGGGGGGG GGGCTCTTCC GGGCTGTCTC CCTCCGGGGC GGGGGTTTCT GGCCGTGGGG GTCTTGCCTG GCCTCCGGGC TCCTGCTTGT CTTGCCTCC TTCTCTGGTC GGTTGTGGCT CGGGGCTCCG TGGGTCCCTG GCGCCCGTTT GTGTTTTGTC TTTTCCCCTG GCGTCCCTGT GCCCCTCTCC TCTCCTTCCT CTGCITCTCG CTCTCCTTTG TGGGGCCCTC CCTGcTGCTC TTGGTITTGG GCTIT-ITC TCTTCCTCCT TTTTCGTGCG TGGGCCTCCG CACGCCTCTT GCCACCTCCT GCGCAGGGCA GCGCCTTGG GGCCAGCGCC GCTCCCGGCG CGGCCAGCAG GGCAGCCAGC AGCGCGCAGC CGACGGCCAG CATGCTTCCT CCTCGGCTAC CACTCCATGG TCCCGCAGAG GCGGACAGGC GCBCGCCTC TTGCCBCCTC CTGCGCBGGG CBGCGCCTTG GGGCCBGCGC CGCTCCCGGC GCGGCCBGCB GGGCBGCCBG CBGCGCGCBG CCGBCGGCCB GCBTGCTTCC TCCTCGGCTB CCBCTCCBTG GTCCCGCBGB GGCGGBCBGG C-3' (FRAG. NO: 1769) (SEQ. ID NO: 1780) 5'-CCCGGCGC-3' (FRAG. NO:1184) (SEQ. ID NO:1194) 5'-GGCCBGCBGG-3' (FRAG. NO:1186) (SEQ. ID NO:1196) 5'-GCBGCCBGCBGCG-3' (FRAG. NO: 1770) (SEQ. ID NO: 1781) WO 00/09525 PCT/US99/17712 EPI-109 176 5-C GCBGCCGBCGGCC -3' (FRAG. NO: 1771) (SEQ. ID NO: 1782) 5'-GGGGGTGGCTTCCTGCC3'- (FRAG. NO:1153) (SEQ. ID NO:1163) 5'-GCGTCTCTGGGCCGTCCC-3' (FRAG. NO:1154) (SEQ. ID NO:1164) 5'-GTCCCTCGGCCCCGCGCCGCGCTCGGCTCCTCTCCC-3' (FRAG. NO:1155) (SEQ. ID NO:1165) 5'-TCrGGCCCGGCTC-3' (FRAG. NO:1156) (SEQ. ID NO:1166) 5'-GGGGCGGGGCGGGGCGGTGGGCGGGC-3' (FRAG. NO:1157) (SEQ. ID NO:1167) 5'-GGCGCTGCCCTGCGC-3' (FRAG. NO:1158) (SEQ. ID NO:1168) 5'-GCGGCGCTGGCCCC-3' (FRAG. NO:1159) (SEQ. ID NO:1169) 5'-TGCTGGCCGTCGGCTGCGCGCTGCTGGCTGCCCT-3' (FRAG. NO:1160) (SEQ. ID NO:1170) 5'-GCTGGCCGCGCCGGG-3' (FRAG. NO:1161) (SEQ. ID NO:1171) 5'-GCCTGTCCGCCTCTGCGGG-3' (FRAG. NO:1162) (SEQ. ID NO:1172) 5'-CGCTGTCTCCTGGC-3' (FRAG. NO:1163) (SEQ. ID NO:1173) 5'-TTrGTCTTrCCGGCTCT-3' (FRAG. NO:1164) (SEQ. ID NO:1174) 5'-TCTGCTGGGGTGGG-3' (FRAG. NO:1165) (SEQ. ID NO:1175) 5'-GCTGGGCGGCCGGCCCGGT-3' (FRAG. NO:1166) (SEQ. ID NO:1176) 5'-GCTGGGGCTCCTCGGGGGG-3' (FRAG. NO:1167) (SEQ. ID NO:1177) 5'-GGGGGCTCTTCCGG-3' (FRAG. NO:1168) (SEQ. ID NO:1178) 5'-GCTGTCTCCCTCCGGG-3' (FRAG. NO:1169) (SEQ. ID NO:1179) 5'-GCGGGGGTITCTGGCC-3' (FRAG. NO:1170) (SEQ. ID NO:1180) 5'-GTGGGGGTCTTGCC-3' (FRAG. NO:1171) (SEQ. ID NO:1181) 5'-TGGCCTCCGGGCTCC-3' (FRAG. NO:1172) (SEQ. ID NO:1182) 5'-TGCTTGTCTTGCCTCCTTC-3' (FRAG. NO:1173) (SEQ. ID NO:1183) 5'-TCTGGTCGGTTGTGGCTCG-3' (FRAG. NO:1174) (SEQ. ID NO:1184) 5'-GGGCTCCGTGGGTCCCTGGC-3' (FRAG. NO:1175) (SEQ. ID NO:1185) 5'-GCCCGTGTGTTTTGTC-3' (FRAG. NO:1176) (SEQ. ID NO:1186) 5'-nTrCCCCTGGCGT-3' (FRAG. NO:1177) (SEQ. ID NO:1187) 5'-CCCTGTGCCCCTCTCCTCTCCTTCCTCTGCTCTC-3' (FRAG. NO:1178) (SEQ. ID NO:1188) 5'-GCTCTCC=GTGGG-3' (FRAG. NO:1179) (SEQ. ID NO:1189) 5'-GCCCTCCCTGCTGCT-3' (FRAG. NO:1180) (SEQ. ID NO:1190) 5'-CTTGGTTITGGGCT-3' (FRAG. NO:1181) (SEQ. ID NO:1191) 5'-TITITICTCTTCCTCCUTITTC-3' (FRAG. NO:1182) (SEQ. ID NO:1192) 5'-GTGCGTGGGCCTCC-3' (FRAG. NO:1183) (SEQ. ID NO:1193) 5' GCACGCCTCTrGCCACCTCCTGCGCAGGGCAGCGCCTTGGGGCCAGCGCCGCTCCCGGCGCGGCCAGCAGGGCAGCCAGCAGCG CGCAGCCGACGGCCAGCATGCTTCCTCCCGGCTACCACTCCATGGTCCCGCAGAGGCGGACAGGC-3' (FRAG. NO:1185) (SEQ. ID NO:1195) 5' GCBCGCCTCT7GCCBCCTCCTGCGCBGGGCBGCGCCITGGGGCCBGCGCCGCTCCCGGCGCGGCCBGCBGGGCBGCCBGCBGCGC GCBGCCGBCGGCCBGCBTGCTrCCTCCTCGGCTBCCBCTCCBTGGTCCCGCBGBGGCGGBCBGGC-3' (FRAG. NO:1187) (SEQ. ID NO:1197) Human IL-6 Nucleic Acid and Antisense Oligonucleotide Fragments 5--GGGGGTGGCT TCCTGCCGCG TCTCTGGGCC GTCCCGTCCC TCGGCCCCGC GCCGCGCTCG GCTCCTCTCC CTCTGGCCCG GCTCGGGGCG GGGCGGGGCG GTGGGCGGGC GGCGCTGCCC TGCGCGCGGC GCTGGCCCCT GCTGGCCGTC GGCTGCGCGC TGCTGGCTGC CCTGCTGGCC GCGCCGGGGC CTGTCCGCCT CTGCGGGCGC TGTCTCCTGG CTTGTCTTCC GGCTCTTCTG CTGGGGTGGG GCTGGGCGGC CGGCCCGGTG CTGGGGCTCC TCGGGGGGGG GGGCTCTTCC GGGCTGTCTC CCTCCGGGGC GGGGGTITCT GGCCGTGGGG GTCTTGCCTG GCCTCCGGGC TCCTGCTTGT CGCCTrCC TTCTCTGGTC GGTTGTGGCT CGGGGCTCCG TGGGTCCCTG GCGCCCGIT GTGTTGTC TTCCCCTG GCGTCCCTGT GCCCCTCTCC TCTCCTCCT CTGCTTCTCG CTCTCCTITG TGGGGCCCTC CCTGCTGCTC TTGGTTTTGG GCYITIIC TCTTCCTCCT TFTTCGTGCG TGGGCCTCC GCACGCCTCT TGCCACCTCC TGCGCAGGGC AGCGCCTTGG GGCCAGCGCC GCTCCCGGCG CGGCCAGCAG GGCAGCCAGC AGCGCGCAGC CGACGGCCAG CATGCTTCCT CCTCGGCTAC CACTCCATGG TCCCGCAGAG GCGGACAGGC GCBCGCCTC TTGCCBCCTC CTGCGCBGGG CBGCGCCTG GGGCCBGCGC CGCTCCCGGC GCGGCCBGCB GGGCBGCCBG CBGCGCGCBG CCGBCGGCCB GCBTGCTICC TCCTCGGCTB CCBCTCCBTG GTCCCGCBGB GGCGGBCBGG C-3' (FRAG. NO:1772) (SEQ. ID NO:1783) 5'-GGGGCBGG-3' (FRAG. NO:1773) (SEQ. ID NO:1784) 5'-GBBGGCBG CBGGC-3' (FRAG. NO:1774) (SEQ. ID NO:1785) 5'-CCBGGBGCBG CCCC-3' (FRAG. NO:1775) (SEQ. ID NO:1786) 5'-BGGG BGBBGGCBBC-3' (FRAG. NO:1776) (SEQ. ID NO:1787) 5'-GCT TCTCT TCG TTC CCG GTG GGC TCG-3' (FRAG. NO:1188) (SEQ. ID NO:1198) 5'-GTG GCT GTC TGT GTG GGG CGG CT-3' (FRAG. NO:1189) (SEQ. ID NO:1199) 5'-GTG CCT CIT TGC TGC TT C-3' (FRAG. NO:1190) (SEQ. ID NO:1200) 5'-GAT TCT TTG CCT TT TCT GC-3' (FRAG. NO:1191) (SEQ. ID NO:1201) 5'-CTCCTGGGGG TBCTGGGGCB GGGBBGGCBG CBGGCBBCBC CBGGBGCBGC CCCBGGGBGB BGGCBBCTGG BCCGBBGGCG CTTGTGGBGB BGGBGTTCBT BGCTGGGCTC CTGGBGGGGB GBTBGBGC-3' (FRAG. NO:1777) (SEQ. ID NO:1788) Human Monocyte-derived Neutrophil Chemotactic Factor Nucleic Acid and Antisense Oligonucleotide Fragments 5'-GGGGTGGBBB GGTTTGGBGT BTGTCITBT GCBCTGBCBT CTBBGTTCTT TBGCBCTCCT TGGCBBBBCT GCBCCTCBC BCBGBGCTGC BGBBBTCBGG BBGGCTGCCB BGBGBGCCBC GGCCBGCTfG GBBGTCBTGT TTBCBCBCBG TGBGBTGGTT CCTTCCGGGC TrGTGTGCTC TGCTGTCTCT TGGTTCCTTC CGGTGGTTTC ITCCTGGCTC TTGTCCTTTC TCTTGG CCCT TGGC-3' (FRAG. NO:1778) (SEQ. ID NO: 1789) WO 00/09525 PCT/US99/17712 EPI-109 177 5'-GGBGT BTG-3' (FRAG. NO:1779) (SEQ. ID NO: 1790) 5'-GCBCTGBCBT CT-3' (FRAG. NO:1780) (SEQ. ID NO:1791) 5'-CCG GTG G-3' (FRAG. NO:1781) (SEQ. ID NO: 1792) 5'-GG CCC TG GC-3' (FRAG. NO:1782) (SEQ. ID NO: 1793) 5'-GCT TGT GTG CTC TGC TGT CTC T-3' (FRAG. NO:1192) (SEQ. ID NO:1202) 5'-TGG TTC CIT CCG GTG GTT TCT TCC TGG CTC FG TCC T-3' (FRAG. NO:1193) (SEQ. ID NO:1203) 5'-TTC TCT TGG CCC T'G GC-3' (FRAG. NO:1194) (SEQ. ID NO:1204) 5'-GGGGTGGBBB GGTTTGGBGT BTGTCTTBT GCBCTGBCBT CTBBGTTCTT TBGCBCTCCT TGGCBBBBCT GCBCCTTCBC BCBGBGC-3' (FRAG. NO:1783) (SEQ. ID NO: 1794) Human Neutrophil Elastase (Medullasin) Nucleic Acid and Antisense Oligonucleotide Fragments 5'-GGGCTCCCGC CGCGBGBGGT TBTGGGCTCC CBGGBCCBCC CGCBCCGCGC GGBCGTTBC BTTCGCCBCG CBGTGCGCGG CCGBCBTGBC GBBGTTGGGC GCBBTCBGGG TGGCGCCGCB GBBGTGGCCT CCGCGCBGCT GCBGGGBCBC CBTGBBGGGC CBCGCGTGGG GCCGCGCTCG CCGGCCCCCC BCBBTCTCCG BGGCCBGCGC GGTGCCCCCC BGCBGCBBGG CCGGCBGGBC BCBGGCGBGG BGBCBCGCGB GTCGGCGGCC GBGGGTCBTG GTGGGGCTGG GGCTCCGGGG TCTCTGCCCC TCCGTGCTGG TGGGGCTGGG GCTCCGGGG TCTCTGCCCC TCCGTGCCGC GTGGGGCCGC GCTCGCCGGC CCCCCCCTGC CGGGTGGGCT CCCGCCGCGC GCCGGCCTGC CGGCCCCrCG TGGGTCCTGC TGGCCGGGTC CGGGTCCCGG GGGTGGGGCG CGBGTCGGCG GCCGBGGGTC-3' (FRAG. NO:1784) (SEQ. ID NO: 1795) 5'-GG TGG GGC-3' (FRAG. NO:1785) (SEQ. ID NO: 1796) 5'-G GGG CCG -3' (FRAG. NO:1786) (SEQ. ID NO:1797) 5'- GGC CGG GTC CGG G-3' (FRAG. NO:1787) (SEQ. ID NO: 1798) 5'-TGG TGG GGC TGG GGC TCC GGG GTC TCT GCC CCT CCG TGC-3' (FRAG. NO:1195) (SEQ. ID NO:1205) 5'-CGC GTG GGG CCG CGC TCG CCG GCC CCC C-3' (FRAG. NO:1196) (SEQ. ID NO:1206) 5'-CCr GCC GGG TGG GCT CCC GCC GCG-3' (FRAG. NO:1197) (SEQ. ID NO:1207) 5'-CGC CGG CCT GCC GGC CCC TC-3' (FRAG. NO:1198) (SEQ. ID NO:1208) 5'-GTG GGT CCT GCT GGC CGG GTC CGG GTC CCG GGG GTG GGG-3' (FRAG. NO:1199) (SEQ. ID NO:1209) 5'-CGC GBG TCG GCG GCC GBG GGT C-3' (FRAG. NO:1200) (SEQ. ID NO:1210) 5 -GGGCTCCCGC CGCGBGBGGT TBTGGGCTCC CBGGBCCBCC CGCBCCGCGC GGBCGTTTBC BTTCGCCBCG CBGTGCGCGG CCGBCBTGBC GBBGTTGGGC GCBBTCBGGG TGGCGCCGCB GBBGTGGCCT CCGCGCBGCT GCBGGGBCBC CBTGBBGGGC CBCGCGTGGG GCCGCGCTCG CCGGCCCCCC BCBBTCTCCG BGGCCBGCGC GGTGCCCCCC BGCBGCBBGG CCGGCBGGBC BCBGGCGBGG BGBCBCGCGB GTCGGCGGCC GBGGGTCBTG GTGGGGCTGG GGCTCCGGGG TCTCTGCCCC TCCGTGC-3' (FRAG. NO:1788) (SEQ. ID NO: 1799) Human Neutrophil Oxidase Factor Nucleic Acid and Antisense Oligonucleotide Fragments 5'-CGGGBGTGGG GGTCCTGGBC GGCBCTGBBG GCBTCCBGGG CTCCCTTCCB GTCCTTCTTG TCCGCTGCCB GCBCCCCTTC BTTCCBGBGG CTGBTGGCCT CCBCCBGGGB CBTGBTTBGG TBGBBBCTBG GBGGCCGGCC TCCBCCBGGG BCBTGGTCCT TCTGTCCGC TGCCTCTCTG GGGTTTCGG TCTGGGTGGG CTTCCTCCT GGGGCTGCTG CTGGGCTCT TL GTTT CTGGCCTGGT GCTCTCTCGT GCCCTCCC TTGGGTGTCT TGIITI GTG GCCTCCBCCB GGGBCBTG-3' (FRAG. NO:1789) (SEQ. ID NO: 1800) 5'-CGGGBGTGGG GG-3 '(FRAG.NO:1790) (SEQ. ID NO: 1801) 5'-GCCBGCBCCCC-3' (FRAG.NO:1791) (SEQ. ID NO: 1802) 5-C CBC CBG-3' (FRAG.NO:1792) (SEQ. ID NO: 1803) 5'-GGC CTC CBC CBG GGB CBT G-3' (FRAG. NO:1201) (SEQ. ID NO:1211) 5'-GTC CTT CIT GTC CGC TGC C -3' (FRAG. NO:1202) (SEQ. ID NO:1212) 5'-TCT CTG GGG TTT TCG GTC TGG GTG G-3 (FRAG. NO:1203) (SEQ. ID NO:1213) 5'-GCT TTC CTC CTG GGG CTG CTG CTG-3' (FRAG. NO:1204) (SEQ. ID NO:1214) 5'-GGC TCT TCT T' TOT TTC TGG CCT GGT G-3' (FRAG. NO:1205) (SEQ. ID NO:1215) 5'-CTC TCT CGT GCC CIT TCC-3' (FRAG. NO:1206) (SEQ. ID NO:1216) 5'-CIT GGG TT CIT T 'ITT GT-3' (FRAG. NO:1207) (SEQ. ID NO:1217) 5'-GGC CTC CBC CBG GGB CBT G-3' (FRAG. NO:1208) (SEQ. ID NO:1218) 5'-CGGGBGTGGG GGTCCTGGBC GGCBCTGBBG GCBTCCBGGG CTCCCTTCCB GTCCTTCTTG TCCGCTGCCB GCBCCCCTTC BTTCCBGBGG CTGBTGGCCT CCBCCBGGGB CBTGBTTBGG TBGBBBCTBG GBGGCC-3' (FRAG. NO:1793) (SEQ. ID NO: 1804) Human Cathepsin G Nucleic Acid and Antisense Oligonucleotide Fragments 5'-CCCTCCBCBT CTGCTCTGBC CTGCTGGBCT CTGGBTCTGB BGBTBCGCCB TGTBGGGGCG GGBGTGGGGC CTGCTCTCCC GGCCTCCGBT GBTCTCCCCT GCCTCBGCCC CBGTGGGTBG GBGBBBGGCC BGCBGBBGCB GGBGTGGCTG CBTCTTTCCT GGTGGGGCCT GCTCTCCCGG CCTCCGTGTG TTGCTGGGTG TTTTCCCGTC TCTGGTCTGC CTTCGGGGGT CGT-3' (FRAG. NO:1794) (SEQ. ID NO: 1805) 5'-GBBGBTBCGCC-3' (FRAG. NO:1795) (SEQ. ID NO: 1806) 5'-CBGCCCCBG-3' (FRAG. NO:1796) (SEQ. ID NO: 1807) 5'-TCC CGT CTC TGG-3' (FRAG. NO:1797) (SEQ. ID NO: 1808) 5'-GTG GGG CCT GCT CTC CCG GCC TCC G-3' (FRAG. NO:1209) (SEQ. ID NO:1219) 5'-TGT GTT GCT GG GTG TIT TCC CGT CTC TGG-3' (FRAG. NO:1210) (SEQ. ID NO:1220) 5'-TCT GCC 'TC GGG GGT CGT-3' (FRAG. NO:1211) (SEQ. ID NO:1221) 5'-CCCTCCBCBT CTGCTCTGBC CTGCTGGBCT CTGGBTCTGB BGBTBCGCCB TGTBGGGGCG GGBGTGGGGC CTGCTCTCCC GGCCTCCGBT GBTCTCCCCT GCCTCBGCCC CBGTGGGTBG GBGBBBGGCC BGCBGBBGCB GGBGTGGCTG-3' (FRAG. NO:1798) (SEQ. ID NO: 1809) Human Defensin I Nucleic Acid and Antisense Oligonucleotide Fragments 5'-CCGGGGCTGC BGCBBCCTCB TCBGCTCTTG CCTGGBGTGG CTCBGCCTGG GCCTGCBGGG CCBCCBGGBG BBTGGCBGCB BGGBTGGCGB GGGTCCTCBT GGCTGGGGTC BCBGBTCCTC TBGCTBGGCB GGGTGBCCBG BGBGGGC GGG TCC TCB TGG WO 00/09525 PCT/US99/17712 EPI-109 178 CTG GGG GCC TGG GCC TGC BGG GCC GCT CTT GCC TGG BGT GGC TC GCC CBG BGT CTT CCC TGG T GCTCAGCCTC CAAAGGAGCC AGCCTCTCCC CAGTTCCTGA AATCCTGAGT GTTGCCTGCC AGTCGCCATG AGAACTTCCT ACCTTCTGCT GTTACTCTC TGCTTACTTT TGTCTGAGAT GGCCTCAGGT GGTAACTTTC TCACAGGCCT TGGCCACAGA TCTGATCATT ACAATTGCGT CAGCAGTGGA GGGCAATGTC TCTATTCTGC CTGCCCGATC TTTACCAAAA TTCAAGGCAC CTGTTACAGA GGGAAGGCCA AGTGCTGCAA GTGAGCTGGG AGTGACCAGA AGAAATGACG CAGAAGTGAA ATGAACTlTT TATAAGCATT C1111AATAA AGGAAAATTG CTT1GAAGT AT CTGCAGTGGT AAAAAGATTC TATATCTGCT GTTTGATGAA TGCAGCACCC ACTAGCCACA TAGTGCTCGT GAGCACTTGC AATGCGGCTA GGGTGATC AATTAACCTA AAAGAGAACA GCCACAGGGA GCATGTGGCT GCCATATTGG ATGGTGCTGC TTTGAGAACA AAATGAGAGA AATGAAGCCT CTATTTACCT TGGTTGGCGG AACACATTGA AGGGACTCTG TATTGATACC AGGCTTCAAA CTTTGGGAAG TGTACTGGCC AACTTAAACA CATCCACAGG AGAATGAAGA GGTTTGGGAA GGGACCAGAA ACCAGGCATT GAGGACAATG AGAAGAGTTT TTCAAAAGTG GAATTACTGC AAAAAGTGGA AAAATAGCCT TTGGATGGAA GTTACTGATG AGACAATTTC CATCGGTGTG AAAGCCATCT TTCCAACAGA GATCTGCAAC ATGAGAATGT ACTGTCTCCT AGGGTAGCGA TGGCCTCTTG TATTAGTCCG CTCAGGCTAC CAGATTTATC GTTTAAACTG CCCATAAACA GACCAGGCAG TTTAAACAAC AGAAATTTAT TTCCTCGCAG TCCTGGAGGC AGGAAGTCTG CGATCAAGGT GGAAGCAGGG TTGGCTTCTT CTCAGGTGTC TGTCCTTGGC TGGTAGATGA CCGCCGCCTC CCTGGGTCCT CACATGGTCT TTCCTCTGTG TGTGTCTGTC CCAATCTCTT CTTATAAGGA TGCAAGTCTT ATGGATCAGA GCACACCCCA ATGACCGTGT TTAACTTGAA TCACCTCTTT AAAGTTTCTC TCTCCAAATA CAATCACCTC CTGAGGCACT GTTAGGGCTT CGACACAGGA ATTCTTTTCC TAGGGGATTC AGTTCAGTCC AAAACGCCTA CCAGTGGAGA CTTGCAACAT GGCGGCCTGC TGGTCCCTCG CCAGGAATAT CACAGGCGAC TGTTCCCTGT TGCATGGAAT AGAAGGCTAT TCCAGAGTAC TGTCTCTATT TATCAGATCT GGGATACTGG GAGAAGGGCA AAATAAAGTC CAAGTAGAAA AAAAAACTAT GAAAGTITrA GAGAGTAACC ATAATTTCAG CCCGATGTGA AACGATCCTA GATTCAGCT GAAATAGTGA TGTGGGAAGT GAGGGGGCCG GGATTCAAGG CAGAGGGAAC AGCGTAACTG AAGGCATGGA AGGAGGGAAG TGTAGGCTGT GTTTGAAGAG TGGCAGCTGC TTCCACATTT CTAAAACACA GGATGTGATT TTGGGGTGTG TTGAGACAAG GCAGAAAACT TGTTGGAAA AATAACTTGA ATTCCCTGCA CATTTAAAAT CTCTCAGCAG AAGAAAACCC CACTCAGAAC CCCACTGTTC ATTCCTTGGC TTGTATTTGG SCACAGCTGG CATAGCCCCA GACTGAGTAA GCTCTTCAGA CACCTCATTT CATGAGTAGC CCCAAAGATC AATCATGGGC CAATTTCTTG GAAGAGAAGA CTCTCCGGTG TTTTGCAGTT ATTTGTTCTG CTTTCGCGAG ATGTTCTCAA ATCGTTGCAG CTACAAGCCA TGAGTCTGAA GTG-TGTGT TCCCTCCTTA CAGGTGGTAA CTTTCTCACA GGCCTTGGCC ACAGATCTGA TCATTACAAT TGCGTCAGCA GTGGAGGGCA ATGTCTCTAT TCTGCCTGCC CGATCTTTAC CAAAATTCAA GGCACCTGTT ACAGAGGGAA GGCCAAGTGC TGCAAGTGAG CTGAGAGTGA CCAGAAGAAA TGACGCAGAA GTGAAATGAA C1TT1TTATAA GCATTCT T AATAAAGGAA AATrGC-I r GAAGTATACC TCCTTGGGC CAAAATGAAT CTTGTGTCTC AATrGGAAGA GGTAAAGAAG TAGGGGGTrA GGGTGCATGG GTTGGAACGT GAGACAGGTC GAACCACAAA GCCTGCCTGG AAAAGGGGAG TGACGTCCTA GGCTTrCAGTG ATGTCACCTC CACTTTGTTT GATCCACAAA CCAACAGGTG ACTGATTTTG GTCAGCTCAG CCTCCAAAGG AGCCAGCCTC TCCCCAGTTC CTGAAATCCT GAGTGTTGCC TGCCAGTCGC CATGAGAACT TCCTACCTTC TGCTGTTTAC TCTCTGCTTA CT1TiGTCTG AGATGGCCTC AGGTGGTAAC TITCTCACAG GCCTTGGCCA CAGATCTGAT CATTACAATT GCGTCAGCAG TGGAGGGCAA TGTCTCTATT CTGCCTGCCC GATCTTTACC AAAATTCAAG GCACCTGTTA CAGAGGGAAG GCCAAGTGCT GCAAGTGAGC TGGGAGTGAC CAGAAGAAAT GACGCAGAAG TGAAATGAAC TT -3' (FRAG.NO:1799) (SEQ. ID NO: 1810) 5'-GTCAGCTCAG CCTCCAAAGG AGCCAGCCTC TCCCCAGTTC CTGAAATCCT GAGTGTTGCC TGCCAGTCGC CATGAGAACT TCCTACCTTC TGCTGTITAC TCTCTGCTTA C-TTTTGTCTG AGATGGCCTC AGGTGGTAAC TTTCTCACAG GCCTTGGCCA CAGATCTGAT CATTACAATT GCGTCAGCAG TGGAGGGCAA TGTCTCTATT CTGCCTGCCC GATCITTACC AAAATTCAAG GCACCTGTTA CAGAGGGAAG GCCAAGTGCT GCAAGTGAGC TGGGAGTGAC CAGAAGAAAT GACGCAGAAG TGAAATGAAC TT-3' (FRAG.NO:_) (SEQ. ID NO: 2475) 5'-CTGCAGTGGT AAAAAGATTC TATATCTGCT GTTTGATGAA TGCAGCACCC ACTAGCCACA TAGTGCTCGT GAGCACTTGC AATGCGGCTA GGGTGATTTC AATTAACCTA AAAGAGAACA GCCACAGGGA GCATGTGGCT GCCATATTGG ATGGTGCTGC TTTGAGAACA AAATGAGAGA AATGAAGCCT CTATTTACCT TGGTTGGCGG AACACATTGA AGGGACTCTG TATTGATACC AGGCTTCAAA CTTTGGGAAG TGTACTGGCC AACTTAAACA CATCCACAGG AGAATGAAGA GGTTTGGGAA GGGACCAGAA ACCAGGCATT GAGGACAATG AGAAGAGTTT TTCAAAAGTG GAATTACTGC AAAAAGTGGA AAAATAGCCT TTGGATGGAA GTTACTGATG AGACAATC CATCGGTGTG AAAGCCATCT TTCCAACAGA GATCTGCAAC ATGAGAATGT ACTGTCTCCT AGGGTAGCGA TGGCCTCTTG TATTAGTCCG CTCAGGCTAC CAGATTTATC GTAAACTG CCCATAAACA GACCAGGCAG TTTAAACAAC AGAAATTTAT TTCCTCGCAG TCCTGGAGGC AGGAAGTCTG CGATCAAGGT GGAAGCAGGG TTGGCTTCTT CTCAGGTGTC TGTCCTTGGC TGGTAGATGA CCGCCGCCTC CCTGGGTCCT CACATGGTCT TTCCTCTGTG TGTGTCTGTC CCAATCTCTT CTTATAAGGA TGCAAGTCTT ATGGATCAGA GCACACCCCA ATGACCGTGT TTAACTTGAA TCACCTCTTT AAAGTITCTC TCTCCAAATA CAATCACCTC CTGAGGCACT GTTAGGGCTF CGACACAGGA ATrCITITCC TAGGGGATTC AGTTCAGTCC AAAACGCCTA CCAGTGGAGA CTTGCAACAT GGCGGCCTGC TGGTCCCTCG CCAGGAATAT CACAGGCGAC TGTTCCCTGT TGCATGGAAT AGAAGGCTAT TCCAGAGTAC TGTCTCTATT TATCAGATCT GGGATACTGG GAGAAGGGCA AAATAAAGTC CAAGTAGAAA AAAAAACTAT GAAAGTMTA GAGAGTAACC ATAATTTCAG CCCGATGTGA AACGATCCTA GATTTCAGCT GAAATAGTGA TGTGGGAAGT GAGGGGGCCG GGATTCAAGG CAGAGGGAAC AGCGTAACTG AAGGCATGGA AGGAGGGAAG TGTAGGCTGT GTTTGAAGAG TGGCAGCTGC TrCCACATTT CTAAAACACA GGATGTGATT TTGGGGTGTG TTGAGACAAG GCAGAAAACT TGTTGGAAA AATAACTTGA ATTCCCTGCA CATTTAAAAT CTCTCAGCAG AAGAAAACCC CACTCAGAAC CCCACTGTTC ATTCCTTGGC TTGTATTTGG SCACAGCTGG CATAGCCCCA GACTGAGTAA GCTCTTCAGA CACCTCATTT CATGAGTAGC CCCAAAGATC AATCATGGGC CAATTrCTTG GAAGAGAAGA CTCTCCGGTG TTTTGCAGTT ATTTGTTCTG CTTTCGCGAG ATGTTCTCAA ATCGTTGCAG CTACAAGCCA TGAGTCTGAA GTGTTTGTGT TCCCTCCTTA CAGGTGGTAA CTTCTCACA GGCCTTGGCC ACAGATCTGA TCATTACAAT TGCGTCAGCA GTGGAGGGCA ATGTCTCTAT TCTGCCTGCC CGATCTTAC CAAAATTCAA GGCACCTGTT ACAGAGGGAA GGCCAAGTGC TGCAAGTGAG CTGAGAGTGA CCAGAAGAAA TGACGCAGAA GTGAAATGAA CIT1TrATAA GCATTCTIT AATAAAGGAA AATTGCUTIT GAAGTATACC TCCTTTGGGC CAAAATGAAT CTTGTGTCTC AATTGGAAGA GGTAAAGAAG TAGGGGGTTA GGGTGCATGG GTTGGAACGT GAGACAGGTC GAACCACAAA GCCTGCCTGG AAAAGGGGAG TGACGTCCTA GGCTTCAGTG ATGTCACCTC CACTTTM GATCCACAAA CCAACAGGTG ACTGATG-3' (FRAG.NO:_) (SEQ. ID NO: 2474) 5'-GCTCAGCCTC CAAAGGAGCC AGCCTCTCCC CAGTTCCTGA AATCCTGAGT GTTGCCTGCC AGTCGCCATG AGAACTTCCT ACCTTCTGCT GTTTACTCTC TGCTTACTTT TGTCTGAGAT GGCCTCAGGT GGTAACTTTC TCACAGGCCT TGGCCACAGA WO 00/09525 PCTIUS99/17712 EPI-109 179 TCTGATCATr ACAATTGCGT CAGCAGTGGA GGGCAATGTC TCTATTCTGC CTGCCCGATC TTACCAAAA TrCAAGGCAC CTGTTACAGA GGGAAGGCCA AGTGCTGCAA GTGAGCTGGG AGTGACCAGA AGAAATGACG CAGAAGTGAA ATGAACTITT TATAAGCATr CITITAATAA AGGAAAATTG C'ITVITGAAGT AT-3' (FRAG.NO:_) (SEQ. ID NO: 2472) 5-CCGGGGC-3' (FRAG.NO:1800) (SEQ. ID NO: 1811) 5'-GG GCCTGCBGGG CC-3' (FRAG.NO:1801) (SEQ. ID NO: 1812) 5 -GGCBGCB BGG-3' (FRAG.NO:1802) (SEQ. ID NO: 1813) 5-GGG TCC TCB TGG CTG GGG-3' (FRAG. NO:1212) (SEQ. ID NO:1222) 5'-GCC TGG GCC TGC BGG GCC-3' (FRAG. NO:1213) (SEQ. ID NO:1223) 5'-GCT CTT GCC TGG BGT GGC TC-3' (FRAG. NO:1214) (SEQ. ID NO:1224) 5'-GCC CBG BGT CTT CCC TGG T-3' (FRAG. NO:1215) (SEQ. ID NO:1225) 5'-CCGGGGCTGC BGCBBCCTCB TCBGCTCTTG CCTGGBGTGG CTCBGCCTGG GCCTGCBGGG CCBCCBGGBG BBTGGCBGCB BGGBTGGCGB GGGTCCTCBT GGCTGGGGTC BCBGBTCCTC TBGCTBGGCB GGGTGBCCBG BGBGGGC-3' (FRAG.NO:1803) (SEQ. ID NO: 1814) Human Defensin 2 Nucelic Acid and Antisense Oli2onucleotide Fragments 5'-ATCCTTTAAG TCAATGGACT TTGCATCAGT CACACCATCT TTTGTrACTT TGGACTTCCC CAGCTATGTT CAATAATrAC TGTCTTCCC TTGGGCCCCA TTGTAATGGC TACAGCCTCG ACAAAAAGTC TACACT=TGA AGCATTAAGG CTCGGACATC AGCACCAAAT TTTACATCIT TACCATCACT TCAAGTGAGG TGAGGAGCCA GTAGCCTGGA CACTGGTCTC ATCTGGTGAA AGACTGTGGG TAATGGAAGC ATTTCTGTGG GGTGCTGGCA GGACATGTGC ATGGCGAGGC AGGTCATCAG CAGCAAGTGA GAGCTGCCTC TTACTCTA AAGGTGACAT AGCAAATATA CAAAAAAAAA TAAATAAATT ATTAATMTAG GTAGAGCACA TAAAGGCTTT ATTTCATATT CCATTTCTCT GTATGCTTTC TTCACCAGGA AGAAATAGTT TTAGTGTCAG GAATGAATGA GTCTGCCCCT CAATTCCAGC CTGCTCAACA CACAAGGAAA CAAAGCCCTG ACAATCAGAG TGACTCCCTG GTGACTAAGC TCCCAGTCCT GGATGCATAT TTGTTAGCA GTTCTGACAG CA'TTGACCC AGCCCTCTCT CTGCATATCC CATCAGAACC TTCITTTT iTI'CTT' TGAGACTGAG TCTTGCTCTG TCGGAAGCGA CTCCTGTGCC TCAGCCTCCC AAATACCTGG AATTATAGGC GTAAGCCATC ATGCCTGGCT AA1T11GTA TT]TTCATGG AGATGGGGTT TTGCCATGTT GGTCAAATTG GTCTCACACT CCTGACCTCA TGTGATCCAC CTGCCTCAGC CTCCCAAACT GCTGGGATGA CAGGTGTAAG CCACCATGCT AGGCTCAGAA ATTCCIT1 ATAAAAATGT CATTAAGGAT CTTGGCTGCA CAATATCGTT ACCAGCTTCC TTTAAATCCA CTTCTGGCCT GCCAGGAATC AGGTTCTTCA GAACCTGACA TTTTAAATGA AGAGGTCAGG CAGTTCATGA GGAAAGCCTC ATTGTCCCCA TGTCTCTGTC ACTGCTGCAC CCCTGAGACA TCACAGACAT GGACACTGGG GCCTGCTTGT TTCTCAAACT GCCCTTAGAT CGAAAGAGGG AGGAACCAGG ATGAATGCCA CTCATTCC CAAGAAAGGC CCTCTCCTGA GTGCCCGGGA TGGGGCTCTG TCCATTGCCT GGGGCCGCCA ATTGCTACTC TGGGTTACGG AGGAAGGACA GGGTCCTGAG AGACACCAGA GACCTCACAC AGCCCTGAAA ACATGGGGCT CCTTCATAAG TGTTTCCCAT CACCAACAGG GAGACCACGT GGAGGCCTTG CAGCCCCACT CGGTGCT7CT CCACCAAATC CCAAGGGCAG TGACGCTGAC GTCTGTGGAA AGCAGAGAAA GCCCTGGCTC CCAAAGCCCT GAAGTCCCTG TGGAGCTGAC ATTCCCTGAG TGACGGTGTG AATGGAAGGA ACTCAAGTGC GGGTGGTAGG CCACCTCCTG GCCCAGGCCT GGGTGAACTC TGAGGGGACA CATGTAGTCA CAATCCCATC CTCCCATTCT CCTTCTCAGA GGAAGGAAGT GGGCATCCAT CTGCCTCATC TCTCTCCCGT GGGGAAGATG GGGAGTTTCA GGGGAACTIT CACATAAATT TCACCAGCTC AGATCTCCTG TGAGGATGGG GCCCACCATG CTCCCGGTGC TGCCAGAGGC CCTGAGCCCC TCCCAGGGTC CCTGGG'TG AGCCAGCCCT GTATCATCCC CAGGAGCTGA ATGTCAGAGC AATGGATAGA ATTAGATGGA AAGAGCTCTC AATTTGACCT GAGACTGTCC CCAGATACTC AGGAAAAACA GGACGTCGCA CAGAGTGGGC AGCAGGTGAG TGGCAGGTTA TAGGTCCTGA GTTGAG7TT GTTCTCACGT GAGACAGACC CAGCCCCTCA CTCCATTCAC ACACTGGGTT TTAAATGGTG CAAGATAGGA GCAAIT11CT GGTCCCAAGA GCAGGAGGAA GGGATTTTCT GGGGTI7CCT GAGTCCAGAT TTGCATAAGA TCTCCTGAGT GTGCATTGTr CTTGAGGAC CAT7CTCTGA CTCACCAGGT AAGTGGCTGA ATTCTAACCT CTGTAATGAG CATTGCACCC AATACCAGTT CTGAACTCTA CCTGGTGACC AGGGACCAGG ACCTTATAA GGTGGAAGGC TTGATGTCCT CCCCAGACTC AGCTCCTGGT GAAGCTCCCA GCCATCAGCC ATGAGGGTCT TGTATCTCCT CTTCTCGTTC CTCTTCATAT TCCTGATGCC TCTTCCAGGT GAGATGGGCC AGGGAAATAG GAGGGTTGGC CAAATGGAAG AATGGCGTAG AAGTTCTCTG TCTCCTCTCA TTCCCCTCCA CCTATCTCTC CCTCATCCCT CTCTCTCCTT CCTCTCTCTG TGTGTCCCCT CCATCCITIT CTCCTGCTTC TCTCTCTTCT TCCCTCTCTC TCTITICT GTCTTTCTTT TTCCTCTCTC CCTAGAGCAT GTCTTTCTT CTCTCTTT CCTTTCTTCT ACCCACACTr TTAGACTGAA TGCCCTATT AATTGAACAA AGCATTGCTT CCTTCAATAG AAAAGGAGTT TGAGAACCCA ATGGACACCT CACTCGT7CT TCTAAGCCAA TATGAAGGAG CCCAGTAGCT TGTAAATATC ATCTCTTCAC TGCITITCCAT GCTACAACTG CTGAGACTAT GGTrGAAACC TGTTAGGTGA CTiTI1AAAT AAAAGGCAGA AAITI1GATT TTATCTAAAG AAAGTAGTAT AGAATGTCAT TTTCTAAATT TTTATATTTA AAGGGTAGAT ACTGCAACCT AGAGAATTCC AGATAATCTT AAGGCCCAGC CTATACTGTG AGAACTACTG CAGCAAGACA CTCTGCCTCC AGGACITTC TGATCAGAGG CCCTGAGAAC AGTCCCTGCC ACTAGGCCAC TGCAGGT7CA CAGGACAGGG TACAGCCCAT TGAAACCTAC ITTAAACCT GGATGCCTAA CCTTCATTT CTCCTrGATA TTATGAAAAT AAAATAAAAA CCATGAAAGG ATAAAAGAGG GAGAGTGGAA GGGAAGGATG GAGAAAGGGA AAAAGAAAAT TTGAGAGTAA ATCCTAAAAC AATTAATCTA ATAGATATCA TCTTGTGAAA TCCTCATTT ACCAATCTA TTTATGAGTC CTGGGTTTTG TGAGAACAAT GGGGTTCTGA GAGGCACCAG AGACCTCATG -T11CCAAAA CCTAGAACAG TATAATGAAG GAAGGCGGGG AGGCAGGGAG GCAGGGAGGC AGGGAGGCAG GGAGGCGGGC AGGTGGGGAG GGAGGGACGG AAGGAGGGAG GGAGGGAGGG AGGGAGGGAG GGAGGGATAA AAAAAGAAGA ATGAGGTTGA AACCAGGACT TAGATATTAG AAACAAGCCA TTACAAAATT TATTTCTATG GTTAATTGTG GTITTCAACT GTAAGTTACT TGGTGTTAAT 1TCCTATTAA ACAATTTCAG TAAGTTGCAT CTFTTATCC CATCTCAGGT CAAATACTTA ACAGACTAAA TGATTTGAAA AAGCAAAAGT T7ACTGGCTT GTGTGTGTTA AAATGGAGGT ATGGTGGCTT TGATATTATC TCITTGTGGT GGAGCTGAAT TCACAAGAGA TCGTTGCTGA GCTCCTACCA GACCCCACCT GGAGGCCCCA GTCACTCAGG AGAGATCAGG GTCTTTCACA ATCAGGTTCT ACAAAAATAA ACATCCCCCC AACCACAGCA GTGCCAGTTT CCATGTCAGA AACTTAGATC CAAATGACTG ACTCGCGTCT CATTATCATG ATGGAAAAGC CCAGGCT7GA GAAAGAAGCC CGCTGCGGAT TrACTCAAGG CGATACTGAC ACAGGGTTTG TGITITICCA ACATGAGTTT TGAGTTCTTA CACGCTGTTT GCTCIillG TGTG-TITIT CCCTGTTAGG TG-ITITGGT GGTATAGGCG ATCCTGTTAC CTGCCTTAAG AGTGGAGCCA TATGTCATCC AGTCTTTGC CCTAGAAGGT ATAAACAAAT TGGCACCTGT GGTCTCCCTG GAACAAAATG CTGCAAAAAG CCATGAGGAG GCCAAGAAGC TGCTGTGGCT GATGCGGATT CAGAAAGGGC TCCCTCATCA GAGACGTGCG ACATGTAAAC CAAATTAAAC TATGGTGTCC AAAGATACGC AATCTTTATC CTAGTAATTG TGGTCATTGG GTGATGTTGG TTTGGGCAGG CCATCTCTAA TATCCTTGAA ACACCTITTT CTGCTCTCCA GGAAGGGGTC AGGGCTGCCA CAGCGGGGCT TGGAGTGCTT WO 00/09525 PCT/US99/17712 EPI-109 180 TCCAGGGTCA CAGGCATCTG TAT~T=GG A F7CCT1GAC CTTCCCCA1r TA'rCCCGGC A=11CCTAA AACGTGTGCT FfGCrCCTCC TGCATCCTCC CCrrGCATGC CCTCACCTAC CCCACATMT CCCTAAAAAA AGCAAGCCCA ACTCAAAGAC CAGT'rCCCTC ATGGAATCAT AGTGGATCrG CCAAGGGAGG GGATGCCCAG TCCTCTGTTC TrCACAAGAC TCCCTTCTTC TGGCTAAGGT TrCITATGCA A'ITAT GAA ITCACAT F7CTCACC1T TTGATGTA TT AAGAAAGTAT GGAGAAATAT ATCCTCTATC AAA'II1CAT GCCTrCAATA ATCTAATT CATCAGTCAG TG7IITCCA TCC1TACTG TGATGATGCC C'rCCA AACTflMCA TGCATCAGA GATGATG'ITA CCAATrT7~ TGTCTCCA'I1 TGCAGAAArr GTAGCAACCT GTGCAATTC TfTCAGGTIT7G GTCACAGGT~r TAGACTGCTT MIAAG~rCA GCAATFACAG CATCAACAGC TAACATCACA CCTCTCTFGA TTCCACTGG AT7AGCACCT TrGCTAACCT TCTGGAAGGC '17AnrrGGAA ATAGAGCATA CCAGTACAGC AGCAGTGATA GTGCCATCCC CCAGTCTCTC CAMTGTGTT ATTGGCAACA TCTTGGACAA GT-f-AGCTCC AATGCTI=A TATrrATCCT TrAAGTCAAT TGA=ITGCA TCAGTCACAC CATCITIGT TA=TIGGGA CTrCCCCAGC TATGT7CAAT AATTACTGT'r C=CCC1TG GCCCCA~rGT AATGGCTACA GCATCGACAA AAAGTCTACA ='~GAAGCA ITrAAGGCTCA GACATCAGCA CCAAA=IfA CATCI=ACC ATCACTTCAA GTGAGGTGAG GAGCCAGTAG CCTGGACACT GGTCTCATCT GGTGAAAGAC TGTGGGTAAT GGAAGCAT= CTGTGGGGTG GTGGCAGGAC ATGTGCATGG TGAGGCAGGT CATCAGCAGC AAGTGAGAGC TGCCTC'rTAC TrCTAAAGG TGACATAGCA AGTATACAAA AAAAAATAAA ATATFAATIT AGGCAGAGCA CATAAAGGCT 7FTTTCATA T7CCAMCT CTGTATGCTr TCTTCACCAG GAAGAAATAG =ITAGTGTC AGGAATGAAT GAGTCTGCCC CTCAA17CCA GCCTGCTCAG CACACAAGGA AACAAAGCCC TGACAATCAG AGTGACTCCC TGGTGACTAA GCTCCAGTCC TGGATGCATA TFrGMITAGC AGTCTGACA GCATCTGACC CAGCCCTCTC MTGCATACC CCACCAGAAC CTrCCTFT TIrTTTC '1GAGACTG AGTCT7GCTC TGTCGGAJ\GC GATrCCCGTG CCTCAGCCTC CCAAATACCT GGAAT7ATAG GCGTAAGCCA TCATGCCTGG CTAArrrG TATFITCAT GGAGATGGGG TI=GCCATG TrGGTCAAAT TGGTCTCACA CTCCTGACCT CATGTGATCC ACCTGCCTCA GCCTCCCAAA GTGCTGGGAT GACAGGTGTA AGCCACCATG CTAGGCTCAG AAATTTCr~r T7ATAAAAAT GTCAT7AAGG ATCPGGCTG CACAATATCG ITACCAGCTT CCTIAAATC CACCTCTGGC CTGCCAGGAA TCAGGGTTCT TCAGAACCTG ACATI=AAA TGAAGAGGTC AGGCAGGTCA TGAGGAAAGC CTCATTGTCC CCATGTCTCT GTCACTGCTG CACCCCTGAG ACATCACAGA CATGGACACT GGGGCCTGCT TG'TrCTCAA ACTGCCC'FA GATCGAAAGA GGGAGGAACC AGGATGAATG CCACTCA'IM TCCCAAGAAA GGCCCTCTCC TGAGTGCCCG GGATGGGGCT CTGTCCATTG CCTGGGGCCG CCAA77GCTA CTCTGGGTTA CGGAAGAAGG ACAGGGTCCT GAGAGACACC AGAGACC-TCA CACAGCCCTG AAAACATGGG GcCrCAT AAGTGTTTCC CATCACCAAC AGGGAGACCA CGTGGAGGCC TrGCAGCCCT ACTCGGTGCT TCTCCACCAA ATCCCAAGGG CAGTGACGCT GACGTCTGTG GAAAGCAGAG AAAGCCCTGG CTCCCAAAGC CCTGAAGTCC TGTGGAGCTG ACATTCCCTG AGTGACGGTG TGAATGGAAG GAACTCAAGT GCGGGTGGTA GGCCACCTCC TGGCCCAGGC CTGGGTGAAC TCTGAGGGGA CACATGTAGT CACAATCCCA TCCTCCCArr CTCCTrCTCA GAGGAAGGAA GTGGGCATCC ATCTGCCTCA TCTCTCTCCC GTGGGGAAGA TGGGGAG717 CAGGGGAACT TrCACATAAA 7rrCACCAGC TCAGATCTCC TGTGAGGATG GGGCCCACCA TGCTCCCGGT GCTGCCAGAG GCCCTGAGCC CCTCCAGGGT CCCTGGGMIT GAGCCAGCCC TGTATCATCC CCAGGAGCTG AATGTCCGAA CAATGGATAG AArrAGATGG AAAGAGCTCT CAATnTGGCC TGAGACTGTC CCCAGATACT CAGGAAAAAC AGGACGTCGC ACAGAGTGGG CAGCAGGTGA GTGGCAGGTT ATAGGTCCTG AGTITGAGTr TGT7CTCACG TGAGACAGAC CCAGCCCCTC ACTCCAT7CA CACACTGGGT TITAAATGGT GCAAGATAGG AGGAA=IrC TGGTCCCAAG AGCAGGAGGA AGGGATTTC TGGGGTT17CC TGAGTCCAGA TTTGCATAAG ATCTCCTGAG TGTGCATTGT TC1TGAGGA CCATTCTCTG ACTCACCAGG TAAGTGGCTG AATCTAACC TCTGTAATGA GCAT7GCACC CAATACCAGT TCTGAACTCT ACCTGGTGAC CAGGGACCAG GACCT=ATA AGGTGGAAGG =TGATGTCC TCCCCAGACT CAGCrCCTGG TGAAGCTCCC AGCCATCAGC CATGAGGGTC TTGTATCTCC TC~rCTCGTF CCTCTTCATA TrCCTGATGC CTCTTCCAGG TGAGATGGG3C CAGGGAAATA GGAGGGTrGG CCAAATGGAA GAATGGCGTA GAAGTrCTCT GTCTCCTCTC ATI'CCCCTCC ACCTATCTCT CCCTCATCCC TCTCTCTCCT TCCTCTCTCT GTGTGTCCCC TCCATCCIT TCTCCTGC77 CTrCTCTCTFC T-rCCCTCTCT CTCrTTI CTGTCI=CT 'FTICCTCTC TCCCTAGAGC ATGTCTICT 'FrCICTCT TrT=C'r CTACCCACAC TITAGACTG AGTAGACTGA ATGCCCTATT TAA17GAACC AAGCATTGCT TCCTrCAATA GAAAAGGAGT TrGAGAACCC AATGGACAAC TCACTCGTTC T7CTAAGCCA ATATGAAGGA GCCCAGTAGT TTGTAAATAT CATCTC17CA CTGCTICCA TGCTACAACT GCTGAGACTA TGGflGAAAC C-TGTTAGGTG AC'FmAAA TAAAAGGCAG AAA'IIGAT T1rATCTAAA GAAAGTAGTA TAGAATGTCA =I~CTAAAT 'II1ATAT AAAGAGTAGA TACTGCAACC TAGAGAATTC CAGATAATCT TAAGGCCCAG CCTATACTGT GAGAACTACT GCAGCAGACA CTCTGCCCCC AGGACT'=C TGATCAGAGG CCCTGAGAAC AGTCCCTGCC ACTAGGCCAC TGCAGGTTCA CAGGACAGGG ACAGCCCAT7 GAAACCAACT7 ITAAACCTG GATGCCTAAC CTTCAT=C TCCTrGATAT TATGAAAATA AAATAAAAAC CATGAAAGGA TAAAAGAGGG AGAGTGGAAG GGAAGGATGG AGAAAGGGAA AAAGAAAAT-r TGAGAGTAAA TCCTAAAACA A'ITAATCTAA TAGATATCAT CTrGTGAAAT CCrCATrA CCAATCITAT TATGAGTCC TGGGT1TGT GAGAACAATG GGGTTCTGAG AGGCACCAGA GACCTCATAT 717CCAAAAC CTAGAACAGT ATAATGAAGG AAGGAGGGAA GGAGGGAGGG AGGGAGGGAA GGAGGGAAGG AGGGAGGGAG GGAGGGAAAC AAAAAGAAGA ATGAGGT7GA AACCAGGACT TAGATATTAG AAACAAGCCA TTACAAAATr TA'1CTATG GTTAAT7GTG GT1TCAACT GTAAGTrACT TGGTGTrAAT TTCCTATTAA ACAATITCAG TAAGTTGCAT CrlIATC CCATCTCAGA TCAAATACTr AACAGACTAA ATGA'1TGAA AAAGCAAAAG T-frACTGGCT TGTGTGTGTT AAAATGGAGG TATGGTGGCT TTGATAT7AT C==TGTGG TGGAGCTGAA TrCACAAGAG ATCGTTGCTG AGCTCCTGCC AGACCCCACC TGGAGGCCCC AGTCACTCAG GAGAGATCAG GGTC1TCAC AATCAGGTTC TACAAAAATA AACATCCCCC AAACCACAGC AGTGCCAG'IT TCCATGTCAG AAACTTAGAT CCAAATGACT GACTCGCGTC TCA I1ATCAT GATGGAAAAG CCCAGGCTG AGAAAGAAGC CCGCTGCGGA ITTrAGTCAAG GCGATACTGA CACAGGG717r GTGTITTCC AACATGAG~r TrGAGT7CTr ACACGCrGTT TGCTCTT= GTGTGTIT= TCCCTGTTAG GTGTT=GG TGGTATAGGC GATCCTGTTFA CCTGCC=AA GAGTGGAGCC ATATGTCATC CAGTCTITG CCCTAGAAGG TATAAACAAA TTGGCACCTG TGGTCTCCCT GGAACAAAAT GCTGCAAAAA GCCATGAGGA GGCCAAGAAG CTGCTGTGGC TGATGCGGAT TCAGAAAGGG CTCCCTCATC AGAGACGTGC GACATGTAAA CCAAATTAAA CTATGGTGTC CAAAGATACG CAATCT=AT CCTAGTAATT GTGGTCA'FFG GGTGATG~rG G'1GGGCAG GCCATCTCTA ATATCCTTGA AACACC'II TCTGCTCTCC AGGAAGGGGT CAGGGCTGCC ACAGCGGGGC TTGGAGTGC-3' (FRAG. NO:_) (SEQ. ID NO:2473) 5'-GAATrCACAT TTCTCACC17 ITGATGTATr AAGAAAGTAT GGAGAAATAT ATCCTCTATC AAATITCAT GCCTI'CAATA A'I1rCTAAT7 CATCAGTCAG TGrFTICCA TCC'TACTG TGATGATGCC C=rCTCCA AAC'TITICA TTGCATCAGA GATGATGTTA CCAATCTT TGTCTCCA'Fr TGCAGAAATI? GTAGCAACCT GTGCAATC T]?CAGGTI1G GTCACAGGTTr TAGACTGCT7 1TTrAAGTrCA GCAAT[ACAG CATCAACAGC TAACATCACA CCTCTCTrGA ITTCCACTGG AYI7AGCACCT T7GCTAACCT TCTGGAAGGC TrA'TTrGGAA ATAGAGCATA CCAGTACAGC AGCAGTGATA GTGCCATCCC CCAGTCTCTC WO 00/09525 PCT/US99/17712 EPI-109 181 CATTTGTGTT ATTGGCAACA TCTTGGACAA GTTTAGCTCC AATGCTrA TATTATCCT TTAAGTCAAT TGACTTTGCA TCAGTCACAC CATCITiGT TACTTTGGGA CTTCCCCAGC TATGTTCAAT AATTACTGTT CTTCCCTTTG GCCCCATTGT AATGGCTACA GCATCGACAA AAAGTCTACA CTTTGAAGCA TTAAGGCTCA GACATCAGCA CCAAATTA CATCTTTACC ATCACTTCAA GTGAGGTGAG GAGCCAGTAG CCTGGACACT GGTCTCATCT GGTGAAAGAC TGTGGGTAAT GGAAGCAIT CTGTGGGGTG GTGGCAGGAC ATGTGCATGG TGAGGCAGGT CATCAGCAGC AAGTGAGAGC TGCCTCTTAC &TCTAAAGG TGACATAGCA AGTATACAAA AAAAAATAAA ATATTAATTF AGGCAGAGCA CATAAAGGCT TTATCATA TTCCATTTCT CTGTATGCTT TCTTCACCAG GAAGAAATAG TTTTAGTGTC AGGAATGAAT GAGTCTGCCC CTCAATTCCA GCCTGCTCAG CACACAAGGA AACAAAGCCC TGACAATCAG AGTGACTCCC TGGTGACTAA GCTCCAGTCC TGGATGCATA TTTGTTAGC AGTTrCTGACA GCATCTGACC CAGCCCTCTC ITGCATACC CCACCAGAAC CTTCTTTITT TITITITITC TITGAGACTG AGTCTTGCTC TGTCGGAAGC GATTCCCGTG CCTCAGCCTC CCAAATACCT GGAATTATAG GCGTAAGCCA TCATGCCTGG CTAAITlIiG TA-ITITCAT GGAGATGGGG TGCCATG TTGGTCAAAT TGGTCTCACA CTCCTGACCT CATGTGATCC ACCTGCCTCA GCCTCCCAAA GTGCTGGGAT GACAGGTGTA AGCCACCATG CTAGGCTCAG AAATCCTT TTATAAAAAT GTCATTAAGG ATCTTGGCTG CACAATATCG TrACCAGCTT CCTTTAAATC CACCTCTGGC CTGCCAGGAA TCAGGGTTCT TCAGAACCTG ACATITTAAA TGAAGAGGTC AGGCAGGTCA TGAGGAAAGC CTCATTGTCC CCATGTCTCT GTCACTGCTG CACCCCTGAG ACATCACAGA CATGGACACT GGGGCCTGCT TGTITCTCAA ACTGCCCTTA GATCGAAAGA GGGAGGAACC AGGATGAATG CCACTCATTT TCCCAAGAAA GGCCCTCTCC TGAGTGCCCG GGATGGGGCT CTGTCCATTG CCTGGGGCCG CCAATrGCTA CTCTGGGT7A CGGAAGAAGG ACAGGGTCCT GAGAGACACC AGAGACCTCA CACAGCCCTG AAAACATGGG GCTCCTTCAT AAGTGTTCC CATCACCAAC AGGGAGACCA CGTGGAGGCC TTGCAGCCCT ACTCGGTGCT TCTCCACCAA ATCCCAAGGG CAGTGACGCT GACGTCTGTG GAAAGCAGAG AAAGCCCTGG CTCCCAAAGC CCTGAAGTCC TGTGGAGCTG ACATTCCCTG AGTGACGGTG TGAATGGAAG GAACTCAAGT GCGGGTGGTA GGCCACCTCC TGGCCCAGGC CTGGGTGAAC TCTGAGGGGA CACATGTAGT CACAATCCCA TCCTCCCATT CTCCTrCTCA GAGGAAGGAA GTGGGCATCC ATCTGCCTCA TCTCTCTCCC GTGGGGAAGA TGGGGAGTTT CAGGGGAACT TrCACATAAA TTTCACCAGC TCAGATCTCC TGTGAGGATG GGGCCCACCA TGCTCCCGGT GCTGCCAGAG GCCCTGAGCC CCTCCAGGGT CCCTGGGTT GAGCCAGCCC TGTATCATCC CCAGGAGCTG AATGTCCGAA CAATGGATAG AATTAGATGG AAAGAGCTCT CAATTGGCC TGAGACTGTC CCCAGATACT CAGGAAAAAC AGGACGTCGC ACAGAGTGGG CAGCAGGTGA GTGGCAGGTT ATAGGTCCTG AGTrGAGT'F TGTTCTCACG TGAGACAGAC CCAGCCCCTC ACTCCATTCA CACACTGGGT TTTAAATGGT GCAAGATAGG AGGAA'TTC TGGTCCCAAG AGCAGGAGGA AGGGATTC TGGGGFTCC TGAGTCCAGA TTTGCATAAG ATCTCCTGAG TGTGCATTGT TCTTGAGGA CCAT7CTCTG ACTCACCAGG TAAGTGGCTG AATTCTAACC TCTGTAATGA GCATTGCACC CAATACCAGT TCTGAACTCT ACCTGGTGAC CAGGGACCAG GACCTTTATA AGGTGGAAGG CTTGATGTCC TCCCCAGACT CAGCTCCTGG TGAAGCTCCC AGCCATCAGC CATGAGGGTC TTGTATCTCC TCTrCTCGTT CCTCTTCATA TTCCTGATGC CTCTTCCAGG TGAGATGGGC CAGGGAAATA GGAGGGTTGG CCAAATGGAA GAATGGCGTA GAAGTTCTCT GTCTCCTCTC ATTCCCCTCC ACCTATCTCT CCCTCATCCC TCTCTCTCCT TCCTCTCTCT GTGTGTCCCC TCCATCCTT TCTCCTGCTT CTCTCrCTTC TTCCCTCTCT CTCflflT CTGTCTCT =ITICCTCTC TCCCTAGAGC ATGTCTITCT TTCTTTCTCT TrCCTTCTT CTACCCACAC TITTAGACTG AGTAGACTGA ATGCCCTAT7 TAATrGAACC AAGCATTGCT TCCTCAATA GAAAAGGAGT TTGAGAACCC AATGGACAAC TCACTCGTTC TTCTAAGCCA ATATGAAGGA GCCCAGTAGT TTGTAAATAT CATCTCTTCA CTGCTTTCCA TGCTACAACT GCTGAGACTA TGGTTGAAAC CTGTTAGGTG ACTI IAAA TAAAAGGCAG AAATTTTGAT TTATCTAAA GAAAGTAGTA TAGAATGTCA TTCTAAAT TATATTT AAAGAGTAGA TACTGCAACC TAGAGAATTC CAGATAATCT TAAGGCCCAG CCTATACTGT GAGAACTACT GCAGCAGACA CTCTGCCCCC AGGAC1TTTC TGATCAGAGG CCCTGAGAAC AGTCCCTGCC ACTAGGCCAC TGCAGGT7CA CAGGACAGGG ACAGCCCATT GAAACCAACT TTTAAACCTG GATGCCTAAC CTTCATTITC TCCTTGATAT TATGAAAATA AAATAAAAAC CATGAAAGGA TAAAAGAGGG AGAGTGGAAG GGAAGGATGG AGAAAGGGAA AAAGAAAAT7 TGAGAGTAAA TCCTAAAACA ATTAATCTAA TAGATATCAT CTTGTGAAAT CCTCATTTTA CCAATCTTAT TTATGAGTCC TGGGTTTGT GAGAACAATG GGGTTCTGAG AGGCACCAGA GACCTCATAT ITTCCAAAAC CTAGAACAGT ATAATGAAGG AAGGAGGGAA GGAGGGAGGG AGGGAGGGAA GGAGGGAAGG AGGGAGGGAG GGAGGGAAAC AAAAAGAAGA ATGAGGTTGA AACCAGGACT TAGATATTAG AAACAAGCCA TTACAAAATT TATTCTATG GTTAATTGTG GTTTCAACT GTAAGTTACT TGGTGTTAAT TTCCTATTAA ACAATTTCAG TAAGTTGCAT CT11111ATC CCATCTCAGA TCAAATACTT AACAGACTAA ATGATGAA AAAGCAAAAG ITACTGGCT TGTGTGTGTT AAAATGGAGG TATGGTGGCT TTGATATTAT CTTCTTGTGG TGGAGCrGAA TTCACAAGAG ATCGTTGCTG AGCTCCTGCC AGACCCCACC TGGAGGCCCC AGTCACTCAG GAGAGATCAG GGTCTTTCAC AATCAGGTTC TACAAAAATA AACATCCCCC AAACCACAGC AGTGCCAGTT TCCATGTCAG AAACTTAGAT CCAAATGACT GACTCGCGTC TCATTATCAT GATGGAAAAG CCCAGGCTTG AGAAAGAAGC CCGCTGCGGA TTTACTCAAG GCGATACTGA CACAGGGTTT GTG1T111CC AACATGAGTT TTGAGTTCTT ACACGCTGTT TGCTCITI I GTGTGrITI TCCCTGTTAG GTG1TTTiGG TGGTATAGGC GATCCTGTTA CCTGCCTTAA GAGTGGAGCC ATATGTCATC CAGTClITG CCCTAGAAGG TATAAACAAA TTGGCACCTG TGGTCTCCCT GGAACAAAAT GCTGCAAAAA GCCATGAGGA GGCCAAGAAG CTGCTGTGGC TGATGCGGAT TCAGAAAGGG CTCCCTCATC AGAGACGTGC GACATGTAAA CCAAATTAAA CTATGGTGTC CAAAGATACG CAATCTTTAT CCTAGTAATT GTGGTCATTG GGTGATGTTG GTTTGGGCAG GCCATCTCTA ATATCCTTGA AACACCTTTT TCTGCTCTCC AGGAAGGGGT CAGGGCTGCC ACAGCGGGGC TrGGAGTGC-3' (FRAG. NO:__) (SEQ. ID NO:2476) 5'-ATCCTITAAG TCAATGGACT TTGCATCAGT CACACCATCT TTrGTrACTT TGGACTTCCC CAGCTATGTT CAATAATTAC TGTTCTTCCC TTGGGCCCCA TTGTAATGGC TACAGCCTCG ACAAAAAGTC TACACTTGA AGCAT7AAGG CTCGGACATC AGCACCAAAT TTACATC=T TACCATCACT TCAAGTGAGG TGAGGAGCCA GTAGCCTGGA CACTGGTCTC ATCTGGTGAA AGACTGTGGG TAATGGAAGC ATTTCTGTGG GGTGCTGGCA GGACATGTGC ATGGCGAGGC AGGTCATCAG CAGCAAGTGA GAGCTGCCTC TTACITTCTA AAGGTGACAT AGCAAATATA CAAAAAAAAA TAAATAAATT ATTAATTTAG GTAGAGCACA TAAAGGCTT ATTrCATATT CCATITCTCT GTATGCTTTC TTCACCAGGA AGAAATAGTT TTAGTGTCAG GAATGAATGA GTCTGCCCCT CAATTCCAGC CTGCTCAACA CACAAGGAAA CAAAGCCCTG ACAATCAGAG TGACTCCCTG GTGACTAAGC TCCCAGTCCT GGATGCATAT TTGTTTAGCA GTTCTGACAG CATfGACCC AGCCCTCTCT CTGCATATCC CATCAGAACC 7rCITTITT- TT1CT1 TGAGACTGAG TCTTGCTCTG TCGGAAGCGA CTCCTGTGCC TCAGCCTCCC AAATACCTGG AATTATAGGC GTAAGCCATC ATGCCTGGCT AATTGTA TfTTCATGG AGATGGGGTT TTGCCATGTT GGTCAAATTG GTCTCACACT CCTGACCTCA TGTGATCCAC CTGCCTCAGC CTCCCAAACT GCTGGGATGA CAGGTGTAAG CCACCATGCT AGGCTCAGAA A'TCCTITr ATAAAAATGT CATTAAGGAT CTTGGCTGCA CAATATCGTT ACCAGCTTCC TTTAAATCCA CTTCTGGCCT GCCAGGAATC AGGTTCTTCA GAACCTGACA TTTAAATGA AGAGGTCAGG CAGTTCATGA GGAAAGCCTC WO 00/09525 PCT/US99/1 7712 EPI-1 09 182 ATTGTCCCCA TGTCTCTGTC ACTGCTGCAC CCCTGAGACA TCACAGACAT GGACACTGGG GCCTG=TGT TTCTCAAACT GCC=TAGAT CGAAAGAGGG AGGAACCAGG ATGAATGCCA CTCATTCC CAAGAAAGGC CCTCTCCTGA GTGCCCGGGA TGGGGCTCTG TCCATI7GCCT GGGGCCGCCA ATrGCTACTC TGGGT7ACGG AGGAAGGACA GGGTCCTGAG AGACACCAGA GACCTCACAC AGCCCTGAAA ACATGGGGCT CC'ITCATAAG TG'IMCCCAT CACCAACAGG GAGACCACGT GGAGGC=~G CAGCCCCACT CGGTG=TCT CCACCAAATC CCAAGGGCAG TGACGCTGAC GTCTGTGGAA AGCAGAGAAA GCCCTGGCTC CCAAAGCCCT GAAGTCCCTG TGGAGCTGAC AT7CCCTGAG TGACGGTGTG AATGGAAGGA ACTCAAGTGC GGGTGGTAGG CCACCTCCTG GCCCAGGCCT GGGTGAACTC TGAGGGGACA CATGTAGTCA CAATCCCATC CTCCCATrcT CC=CTCAGA GGAAGGAAGT GGGCATCCAT CTGCCTCATC TCTCTCCCGT GGGGAAGATG GGGAGTrCA GGGGAA= T CACATAAA'Fr TCACCAGCTC AGATCTCCTG TGAGGATGGG GCCCACCATG CTCCCGGTGC TGCCAGAGGC CCTGAGCCCC TCCCAGGGTC CCTGGGTTTG AGCCAGCCCT GTATCATCCC CAGGAGCTGA ATGTCAGAGC AATGGATAGA ATTAGATGGA AAGAGCTCTC AATITGACCT GAGACTGTCC CCAGATACTC AGGAAAAACA GGACGTCGCA CAGAGTGGGC AGCAGGTGAG TGGCAGGTTA TAGGTCCTGA GT17GAGIM G'TTCTCACGT GAGACAGACC CAGCCCCTCA CTCCAT~rCAC ACACTGGG IT TTAAATGGTG CAAGATAGGA GCAATITCT GGTCCCAAGA GCAGGAGGAA GGGA II1CT GGGGT7rCCT GAGTCCAGAT TTGCATAAGA TCTCCTGAGT GTGCATrGT-r CITGAGGAC CAT-rCrCTGA CTCACCAGGT AAGTGGCTGA ATTCTAACCT CTGTAATGAG CATTGCACCC AATACCAGT7 CTGAACTCTA CCTGGTGACC AGGGACCAGG AC=T]ATAA GGTGGAAGGC 'ITGATGTCCT CCCCAGACTC AGCTCCTGGT GAAGCTCCCA GCCATCAGCC ATGAGGGTCT TGTATCTCCT CrrcCGTTC CTCTTCATAT TCCTGATGCC TCT-FCCAGGT GAGATGGGCC AGGGAAATAG GAGGGTfGGC CAAATGGAAG AATGGCGTAG AAG~rCTCTG TCTCCTCTCA TCCCCTCCA CCTATCTCTC CCTCATCCCT CTCTCTCCM CCTCTCTCTG TGTGTCCCCT CCATCCTI CTCCTG=TC TCTCTMTCT TCCCTCTCTC TC'TT=CT GTC==CI TTCCTCTCTC CCTAGAG CAT GTc'IT1=C =1ICT=T1 CCTICTrCT ACCCACACTI' IAGACTGAA TGCCCTATrT AATTGAACAA AGCATrGCTT CCTCAATAG AAAAGGAG~r TGAGAACCCA ATGGACACCT CACTCGTTCT TCTAAGCCAA TATGAAGGAG CCCAGTAGCT TGTAAATATC ATCrCTrCAC TGC1TCCAT GCTACAACTG CTGAGACTAT GG'ITGAAACC TGTTAGGTGA CTF1TAAAT AAAAGGCAGA AA=IFGATT FATCTAAAG AAAGTAGTAT AGAATGTCAT M~CTAAATr M~ATAT7A AAGGGTAGAT ACTGCAACCT AGAGAATTCC AGATAATCTr AAGGCCCAGC CTATACTGTG AGAACTACTG CAGCAAGACA CTCTGCCTCC AGGACTITC TGATCAGAGG CCCTGAGAAC AGTCCCTGCC ACTAGGCCAC TGCAGGTTCA CAGGACAGGG TACAGCCCAT TGAAACCTAC T1TAAACCT GGATGCCTAA CC=CAITI CTCCTrGATA 17ATGAAAAT AAAATAAAAA CCATGAAAGG ATAAAAGAGG GAGAGTGGAA GGGAAGGATG GAGAAAGGGA AAAAGAAAAT TTGAGAGTAA ATCCTAAAAC AATrAATCTA ATAGATATCA TC=GTGAAA TCCTCATIT ACCAAT=TA TI7rATGAGTC CTGGGTITG TGAGAACAAT GGGGT~cTGA GAGGCACCAG AGACCTCATG TITCCAAAA CCTAGAACAG TATAATGAAG GAAGGCGGGG AGGCAGGGAG GCAGGGAGGC AGGGAGGCAG GGAGGCGGGC AGGTGGGGAG GGAGGGACGG AAGGAGGGAG GGAGGGAGGG AGGGAGGGAG GGAGGGATAA AAAAAGAAGA ATGAGGTTGA AACCAGGACT TAGATATTAG AAACAAGCCA 7rACAAAA'Fr TATI7rCTATG G'ITAATrGTG GTITCAACT GTAAGTrACT TGGTG ITAAT TrC~rA'I7AA ACAA'IMCAG TAAGTrGCAT CITITATCC CATCTCAGGT CAAATACrrA ACAGACTAAA TGATrT7GAAA AAGCAAAAGT TTACTGGCTr GTGTGTGT7A AAATGGAGGT ATGGTGGCT7 TGATAT7ATC TCTTGTGGT GGAGCTGAAT TCACAAGAGA TCGT7GCTGA GCTCCTACCA GACCCCACCT GGAGGCCCCA GTCACTCAGG AGAGATCAGG GTCTICACA ATCAGGTTCT ACAAAAATAA ACATCCCCCC AACCACAGCA GTGCCAG=T CCATGTCAGA AACTTAGATC CAAATGACTG ACTCGCGTCT CATFTATCATG ATGGAAAAGC CCAGGUI1GA GAAAGAAGCC CGCTGCGGAT TrACTCAAGG CGATACTGAC ACAGGG'IMG TGTTCCA ACATGAG'I= TGAG'T=A CACGCTGTT7 GCrC'mTFG TGTGnTI CCCTGTTAGG TGTITIGGT GGTATAGGCG ATCCTGTrAC CTGCCTAAG AGTGGAGCCA TATGTCATCC AGTCTTTGC CCTAGAAGGT ATAAACAAAT TGGCACCTGT GGTCTCCCTG GAACAAAATG CTGCAAAAAG CCATGAGGAG GCCAAGAAGC TGCTGTGGCT GATGCGGATT CAGAAAGGGC TCCCTCATCA GAGACGTGCG ACATGTAAAC CAAATrAAAC TATGGTGTCC AAAGATACGC AATC1TATC CTAGTAATTG TGGTCATrGG GTGATG'ITGG 'IMGGGCAGG CCATCTCTAA TATCCT7GAA ACACCTF= CTGCTCTCCA GGAAGGGGTC AGGGCTGCCA CAGCGGGGCT TGGAGTG=T TCCAGGGTCA CAGGCATCTG TArTTTGG ATrCCTTGAC CTCCCCATT TATTCCCGGC ATTICCTAA AACGTGTGCT TFTGCTCCTCC TGCATCCTCC C=TGCATGC CCTCACCTAC CCCACATCTT CCCTAAAAAA AGCAAGCCCA ACTCAAAGAC CAGT7CCCTC ATGGAATCAT AGTGGATCTG CCAAGGGAGG GGATGCCCAG TCCTCTGTTFC TTCACAAGAC TCCCrrTrC TGGCTAAGGT TrC7rATGCA ATITAT GAAU-CCCTG TAAGCCCTGT TACAGGGGCT GCACCCCAGA TACAACCTGA CCTGTGTCCA AGGCGGGCAA CTCAACCCTTr AGATATTGAA TGGGTCCCAT GGCACCAATG CTAAACACC AGCAGCCCTC ACAACCACAG ATCGTGTIT AAGGATGAGG AGGTAGTTCT CTGGATGCAC AGGCICAAT CCAAATGGGC TCATGACGCC GCAGCACACA CCCAGTCTGC AGCCTGAAGA GTTGGAGCAT TGCAITCACA GAAAGCATCC AGACATGATC ATGGGCTCAG GGATACACCT GTTCTCCGAT GTGTACCAGT GAAGGATGGA AACTCCTATG CCTCCCAGAA AGCACCACTC AAGC1TTGC TGAATGCT7C TCTGAAGGCC CACAAGGCTG AGAGGCTGTG CAACACCAGC AGTAAAGTGA ATGCCCAGAC TCCCACCTCC ==CTGGGT GGCCATCTGG AAAGGCCACT CCCACCCTGA TGGCTAATGC CTCAGACCAG 'FrCITGGCCC AGATGATCCT AGACAA TGT TTAAGCTrAA ACIrGTfCA117 GGCCAAGCAA ACAGGTGATA GTACCTCTGG GGAACCACAT GCCGCGTGTA CATCCAGATC TCAGGAGAAC CCAAAAATGT CTGTrCCACA TAGCAACAGA AGCCCAGGTA GCACTCAGTC TCACCTGGGT GTTCTCCAAC ATCCCAGCTC AGCCAAATGG CTPCATrAG TTI=ATGGT TAGACCCCAG GTCCTCGGGA CACTGC1TA GAAACACATT CCAAATCCTrC CTCTGTGTGC AGGTGGCATT CCTATCCCAA TCTC1TGCA GGGCGTATAC TGTGATACGC AGCCAGGCTG TCCCAGAGGC =~AAATA'T CCCTrGGTGC AGGTAGTTCA G=TAGCCAC AGCCAATGCA TCACAGGGTC AACTGTGTTA GGAGCCATrG AGAATCCATA G FTGGTTGCT GCCTGGGCCT GGCCAGGGCT GACCAAGGTA GATGAGAGGT TCCTCTGTGG AGTTCTACT TAACCTCACC ITCCCACCAA A'ITrC7CAAC TGTCCTGCC ACCACAATTA TIAATGGAC CCAACAGAAA GTAACCCCGG AAATTAGGAC ACCTCATCCC AAAAGACCT TAAATAGGGG AAGTCCAC'F GTGCACGGCT GCTCCT7GCT ATAGAAGACC TGGGACAGAG GACTGCTGTC TGCCCTCTCT GGTCACCCTG CCTAGCTAGA GGATCTGTAA GTACrACAAA ACT7AAA=~ TACACTGAGT nITCATCATT GAAGCTATGC CTrCCAATCTG ACcI7CTGACT GTGGGGCCGC CCCAGAGGGA CCCAGCGGGT GAATCCCTGC TAGGAACGTC TGTCCGGACC TCTGGTGACT GCTGGGGACG ATGGCTrCCA GCTAACTAA TAGAGAAACT CAAGCAGMI CC=CTAAAT ACACATGTCA CATGTCCTGG 771GACATGTC CAGTAAGAAG ACTATCACAG GTC'I1GGAA CAT7CI=fG AGAGAAACCT AMI]AGGTCC TTGGTCTGTr ITrCAATCAG GT7GT1TGAT =IIGCTATr GAGTrGTrGG AATTCCTrAT GTATTCAGAT A'1TrGCCCCT TC7GCCATGT AGG=1TGCA AATA=HCT CTCA'rIr GGGTrAT= T rCACTCGGT TGA FrG 1C C ITGCTGTG CAGATGCTJ AGCGT'TAAAT GAAGCCACAC TrGTCTA'IM TCCCrM~AT TGCCTGTGCC IT!GGTGTCA TAGCCAAGAA ATCATTACCT ACATCAATGT CAAAAG=II ATCCITCTAT ACACITC-rAG TAGITT7ATGG 'I1FCAGTTGT TACAMJAGG TI=CAATTC A'TTCTGAG'F7 GATGTTCCTA WO 00/09525 PCT/US99/17712 EPI-109 183 CATGGTGTGA GATAAAGATT TAAATACATA CATATATAAA ATCATGAGGT AGTGTACACT ATAAATATAC AATTGTTAAT TGTrACTCAA GTCTAAGTAG AGGTGGAAAT AATAAACTT LTITITITA CTTAAACCAC TCTGTGTCAC TGAGCTGATT TCACCTAG CCTGATAAAA TCATTGTCCT CTCCACCCTG ATTCCTACAG GAGACTACTC ACCCCATAAC CTCAAAAACC TCTTCATGAG GATGGTAAGT CACCTGAATC CTGAAGTGAA TTACTCGCTA TTCCATTGGA ACTCATATAG GACACCAGAA TCTAGACCTC CAGAGAACAG CAGGACCCAT CTTCAGAAAA TAAGAAGCAT TrGTTCCCTG AGCCTGTTGA ATCAAAGTGC AA'TrCTATT CTI11GGAA TGTTAAAAAG TGAATCATAA TAT-TTAAGCA GGTGAACCCA CGAGTAACAT AGCAGGGTCT TrCTTGTCAT TATTAGCTCC AACCTAGCAC AGACATTAAA GGTACAGATG TATACTAGCA TGAAACTGGG AGAACAGGAG CATTCGAGCA ACCTTGAGAC CAATGGGCCT CTCTTATAAA ATGCACACCT CCTCTCACTG AGATTGAGGA AGGTCTTG TCTCCGAGCC TTCTCCCAGT AGAGCTATAA ATCCAGGCTG GCTCCTCCCT CCCCACACAG CTGCTCCTGC TCTCCCTCCT CCAGGTGACC CCAGCCATGA GGACCCTCGC CATCCTTGCT GCCATTCTCC TGGTGGCCCT GCAGGCCCAG GCTGAGCCAC TCCAGGCAAG AGCTGATGAG GTTGCTGCAG CCCCGGAGCA GATTGCAGCG GACATCCCAG AAGTGGTTGT T7CCCTrGCA TGGGACGAAA GCTTGGCTCC AAAGCATCCA GGTGAGAGAG GCAGGCATGC AGAGCTGCTA AGTCTAGAGG GAAGGACGGG AGAGAGGTTC CAGAGTTGGG TCTCAGCAGT CTATGTCACT GAGGTGGCTT CACTTAGAAT CTCTGGGCAT TGATTTTCTC ATCTAGAAAT TGAACAGAGA GCCAAATAAA CCTGAGAAAC TITATCTC CAAAGACTTG ATTCCAAGAA ACATCTGTGA AATTCACTAA GTTTAAGATA TGAAGAGACA GACTAGTTAT TrCTGGATCT AAACAAGTAG ACTTAGTTGT AAAGAGAACA TTACTCTA TCTACAGAAG AGCTITTAAA AACTGCAGCC AAGCCTGAGG GTAAGTTCAG GTGTGTGTGT GATGGGGCAG GAATGCAAAA ATGAGAGCAA AGGAGAATGA GTCTCAAATT CTGTGTGACA AGCACTGCTC TGCGTGTTTA TTCCTATCGA CTGAGGTTGT TCGTGCTACC GGCTGCAATG CAGCCAGCAT CACCTGTCAG CTAGCATGTG ACTTCCCCGA GATTC'il CTTACCCACT GCTAACTCCA TACTCAATTT CTCATGCTCT CCCTGTCCCA GGCTCAAGGA AAAACATGGA CTGCTATTGC AGAATACCAG CGTGCATTGC AGGAGAACGT CGCTATGGAA CCTGCATCTA CCAGGGAAGA CTCTGGGCAT TCTGCTGCTG AGCTTGCAGA AAAAGAAAAA TGAGCTCAAA ATTGCTTTG AGAGCTACAG GGAATTGCTA TTACTCCTGT ACCTTCTGCT CAAT'ITCCTT TCCTCATCTC AAATAAATGC CTTGTTACAA GATTCTGTG TTTCCACCTC TTTAATGTGT GATATGTGTC TGTGTCAAGA CACTTGGGAT ACACGTACCA AAACGCAAAA TCAAA1T11- GAACAATATA-3' (FRAG. NO:_) (SEQ. ID NO:2473) Human Defensin 3 Nucleic Acid and Antisense Oligonucleotide Fragments 5-CGCTGCBBTC TGCTCCGGGG CTGCBGCBBC CTCBTCBGCTC TTGCCTGGBGTG GCTCBGCCTGG GCCTGCBGGG CCBCCBGGBGB BTGGCBGCBBG GBTGGCGBGGG TCCTCBTGGC TGGGGTCBCCT GGBGGBGGGB GBGCBGGGGG TCCTCBTGGC TGGGGTCCCT CTCTCCCGTC CT CCTACCTTGC TATAGAAGAC CTGGGACAGA GGACTGCTGT CTGCCCTCTC TGGTCACCCT GCCTAGCTAG AGGATCTGTG ACCCCAGCCA TGAGGACCCT CGCCATCCTT GCTGCCATTC TCCTGGTGGC CCTGCAGGCC CAGGCTGAGC CACTCCAGGC AAGAGCTGAT GAGGTTGCTG CAGCCCCGGA GCAGATTGCA GCGGACATCC CAGAAGTGGT TGTTCCCTT GCATGGGACG AAAGCT7GGC TCCAAAGCAT CCAGGCTCAA GGAAAAACAT GGACTGCTAT TGCAGAATAC CAGCGTGCAT TGCAGGAGAA CGTCGCTATG GAACCTGCAT CTACCAGGGA AGACTCTGGG CATTCTGCTG CTGAGCTrGC AGAAAAAGAA AAATGAGCTC AAAATTTGCT TTGAGAGCTA CAGGGAATrG CTATTACTCC TGTACCTrCT GCTCAATTTC CT-3' (FRAG. NO:1804) (SEQ. ID NO:1815) 5'-CCTACCTTGC TATAGAAGAC CTGGGACAGA GGACTGCTGT CTGCCCTCTC TGGTCACCCT GCCTAGCTAG AGGATCTGTG ACCCCAGCCA TGAGGACCCT CGCCATCCTT GCTGCCATTC TCCTGGTGGC CCTGCAGGCC CAGGCTGAGC CACTCCAGGC AAGAGCTGAT GAGGTTGCTG CAGCCCCGGA GCAGATrGCA GCGGACATCC CAGAAGTGGT TGTTCCCTr GCATGGGACG AAAGCTTGGC TCCAAAGCAT CCAGGCTCAA GGAAAAACAT GGACTGCTAT TGCAGAATAC CAGCGTGCAT TGCAGGAGAA CGTCGCTATG GAACCTGCAT CTACCAGGGA AGACTCTGGG CATTCTGCTG CTGAGCTTGC AGAAAAAGAA AAATGAGCTC AAAATTTGCT TrGAGAGCTA CAGGGAATTG CTATTACTCC TGTACCTTCT GCTCAATTTC CTT-3' (FRAG. NO:__) (SEQ. ID NO:2478) 5'-GAATTCCCTG TAAGCCCTGT TACAGGGGCT GCACCCCAGA TACAACCTGA CCTGTGTCCA AGGCGGGCAA CTCAACCCTT AGATATTGAA TGGGTCCCAT GGCACCAATG CT[AAACACC AGCAGCCCTC ACAACCACAG ATCGTGTT AAGGATGAGG AGGTAGTTCT CTGGATGCAC AGGCTTCAAT CCAAATGGGC TCATGACGCC GCAGCACACA CCCAGTCTGC AGCCTGAAGA GTTGGAGCAT TGCATTCACA GAAAGCATCC AGACATGATC ATGGGCTCAG GGATACACCT GTTCTCCGAT GTGTACCAGT GAAGGATGGA AACTCCTATG CCTCCCAGAA AGCACCACTC AAGCTITTGC TGAATGCTTC TCTGAAGGCC CACAAGGCTG AGAGGCTGTG CAACACCAGC AGTAAAGTGA ATGCCCAGAC TCCCACCTCC TITCTTGGGT GGCCATCTGG AAAGGCCACT CCCACCCTGA TGGCTAATGC CTCAGACCAG TrCTGGCCC AGATGATCCT AGACAATTGT TFAAGCTrAA ACTGTrCATr GGCCAAGCAA ACAGGTGATA GTACCTCTGG GGAACCACAT GCCGCGTGTA CATCCAGATC TCAGGAGAAC CCAAAAATGT CTGTrCCACA TAGCAACAGA AGCCCAGGTA GCACTCAGTC TCACCTGGGT GTTCTCCAAC ATCCCAGCTC AGCCAAATGG CTTTCATTAG TITITATGGT TAGACCCCAG GTCCTCGGGA CACTGCTTA GAAACACATT CCAAATCCTC CTCTGTGTGC AGGTGGCAT7 CCTATCCCAA TCTCTTGCA GGGCGTATAC TGTGATACGC AGCCAGGCTG TCCCAGAGGC CTTAAATATr CCCTTGGTGC AGGTAGTTCA GCTTAGCCAC AGCCAATGCA TCACAGGGTC AACTGTGTTA GGAGCCATTG AGAATCCATA GTTGGTTGCT GCCTGGGCCT GGCCAGGGCT GACCAAGGTA GATGAGAGGT TCCTCTGTGG AGTTCTACTT TAACCTCACC TrCCCACCAA ATTTCTCAAC TGTCCTTGCC ACCACAATTA TTTAATGGAC CCAACAGAAA GTAACCCCGG AAATTAGGAC ACCTCATCCC AAAAGACCTT TAAATAGGGG AAGTCCACTT GTGCACGGCT GCTCCTTGCT ATAGAAGACC TGGGACAGAG GACTGCTGTC TGCCCTCTCT GGTCACCCTG CCTAGCTAGA GGATCTGTAA GTACTACAAA ACTTAAACTT TACACTGAGT TTTCATCATT GAAGCTATGC CTCCAATCTG ACCTCTGACT GTGGGGCCGC CCCAGAGGGA CCCAGCGGGT GAATCCCTGC TAGGAACGTC TGTCCGGACC TCTGGTGACT GCTGGGGACG ATGGCTTCCA GCTAACTTAA TAGAGAAACT CAAGCAGTTT CCTrCTAAAT ACACATGTCA CATGTCCTGG TTGACATGTC CAGTAAGAAG ACTATCACAG GTCTTGGAA CATTCITTG AGAGAAACCT ATTTAGGTCC TTGGTCrGTT TTTCAATCAG GTTGTMTGAT TTIGCTATT GAGTTGTTGG AATTCCTTAT GTATTCAGAT ATTGCCCCT TCTGCCATGT AGGTTTGCA AATATTTTCT CTCATTCT GGGTTATCTT T7CACTCGGT TGATTGTTC CTTTGCTGTG CAGATGCTTT AGCGTTAAAT GAAGCCACAC TTGTCTAT TCCCITAT TGCCTGTGCC TTTGGTGTCA TAGCCAAGAA ATCATTACCT ACATCAATGT CAAAAGCT ATCCTTCTAT ACACTTCTAG TAGITTATGG TTrCAGTTGT TACATTTAGG TTTTCAATTC ATTCTGAGTF GATGTTCCTA CATGGTGTGA GATAAAGATT TAAATACATA CATATATAAA ATCATGAGGT AGTGTACACT ATAAATATAC AATrGTTAAT TGTTACTCAA GTCTAAGTAG AGGTGGAAAT AATAAACTTT CTITITFTA CTTAAACCAC TCTGTGTCAC TGAGCTGATT TCACCTTTAG CCTGATAAAA TCATTGTCCT CTCCACCCTG ATTCCTACAG GAGACTACTC ACCCCATAAC CTCAAAAACC TCTTCATGAG GATGGTAAGT CACCTGAATC CTGAAGTGAA TTACTCGCTA TTCCATTGGA ACTCATATAG GACACCAGAA TCTAGACCTC CAGAGAACAG CAGGACCCAT WO 00/09525 PCT/US99/17712 EPI-109 184 CTTCAGAAAA TAAGAAGCAT TTGTTCCCTG AGCCTGTTGA ATCAAAGTGC AATT7CTATT CTTGGAA TGTTAAAAAG TGAATCATAA TATTTAAGCA GGTGAACCCA CGAGTAACAT AGCAGGGTCT TTCTTGTCAT TATTAGCTCC AACCTAGCAC AGACATTAAA GGTACAGATG TATACTAGCA TGAAACTGGG AGAACAGGAG CATICGAGCA ACCTTGAGAC CAATGGGCCT CTCTTATAAA ATGCACACCT CCTCTCACTG AGATrGAGGA AGGTTTCTG TCTCCGAGCC TTCTCCCAGT AGAGCTATAA ATCCAGGCTG GCTCCTCCCT CCCCACACAG CTGCTCCTGC TCTCCCTCCT CCAGGTGACC CCAGCCATGA GGACCCTCGC CATCCTTGCT GCCATTCTCC TGGTGGCCCT GCAGGCCCAG GCTGAGCCAC TCCAGGCAAG AGCTGATGAG GTTGCTGCAG CCCCGGAGCA GATTGCAGCG GACATCCCAG AAGTGGTTGT TTCCCT'GCA TGGGACGAAA GCTTGGCTCC AAAGCATCCA GGTGAGAGAG GCAGGCATGC AGAGCTGCTA AGTCTAGAGG GAAGGACGGG AGAGAGGTTC CAGAGTTGGG TCTCAGCAGT CTATGTCACT GAGGTGGCTT CACTTAGAAT CTCTGGGCAT TGATCTC ATCTAGAAAT TGAACAGAGA GCCAAATAAA CCTGAGAAAC TTTATITCTC CAAAGACTTG ATTCCAAGAA ACATCTGTGA AATTCACTAA GTTTAAGATA TGAAGAGACA GACTAGTTAT TTCTGGATCT AAACAAGTAG ACTTAGTTGT AAAGAGAACA T1TTACTCTA TCTACAGAAG AGCTTTTAAA AACTGCAGCC AAGCCTGAGG GTAAGTTCAG GTGTGTGTGT GATGGGGCAG GAATGCAAAA ATGAGAGCAA AGGAGAATGA GTCTCAAATT CTGTGTGACA AGCACTGCTC TGCGTGTMTA TTCCTATCGA CTGAGGTTGT TCGTGCTACC GGCTGCAATG CAGCCAGCAT CACCTGTCAG CTAGCATGTG ACTTCCCCGA GATTCTr CTTACCCACT GCTAACTCCA TACTCAATTT CTCATGCTCT CCCTGTCCCA GGCTCAAGGA AAAACATGGA CTGCTATTGC AGAATACCAG CGTGCATTGC AGGAGAACGT CGCTATGGAA CCTGCATCTA CCAGGGAAGA CTCTGGGCAT TCTGCTGCTG AGCTTGCAGA AAAAGAAAAA TGAGCTCAAA ATTTGCTTTG AGAGCTACAG GGAATTGCTA TTACTCCTGT ACCTTCTGCT CAATTTCCTT TCCTCATCTC AAATAAATGC CTTGTTACAA GATTTCTGTG TCCACCTC TTTAATGTGT GATATGTGTC TGTGTCAAGA CACTTGGGAT ACACGTACCA AAACGCAAAA TCAAAITITr GAACAATATA-3' (FRAG. NO:_) (SEQ. ID NO:2477) 5'-GGCBGCBBGG-3' (FRAG. NO:1805) (SEQ. ID NO:1816) 5'-GG CTG GGG-3' (FRAG. NO:1806) (SEQ. ID NO:1817) 5'-GGGGTCBCC-3' (FRAG. NO:1807) (SEQ. ID NO:1818) 5'-GGG TCC TCB TGG CTG GGG TC-3' (FRAG. NO:1216) (SEQ. ID NO:1226) 5'-CCT CTC TCC CGT CCT-3' (FRAG. NO:1217) (SEQ. ID NO:1227) 5'-CGCTGCBBTC TGCTCCGGGG CTGCBGCBBC CTCBTCBGCTC TTGCCTGGBGTG GCTCBGCCTGG GCCTGCBGGG CCBCCBGGBGB BTGGCBGCBBG GBTGGCGBGGG TCCTCBTGGC TGGGGTCBCCT GGBGGBGGGB GBGCBGG-3' (FRAG. NO:1808) (SEQ. ID NO:1819) Human Macrophage Inflammatory Protein-1-alpha/RANTES Receptor Nucleic Acid and Antisense Oligonucleotide Fragments 5'-GTCTTGTT CTGGGCTCGT GCCCCBTCCC GGCTTCTCTC TGGTTCCGTC CTCTGTGGTG TTTGGCCCTG CTTCCTI 1G CCTGTTGAGG GGGCAGCAGT TGGGCCCCAA AGGCCCTCTC GTTCACCTTC TGGCACGGAGTT GCATCCCCATA GTCAAACTCT GTGGTCGTGT CATAGTCCTC TGTGGTGTTT GGAGTTCCA TCCCGGCTTC TCTCTGGTTC CAAGGGAGB GGGGGCBGCB GTTGGGCCCC BBBGGCCCTC TCGTTCBCCT TCTGGCBCGG BGTTGCBTCC CCBTBGTCBB BCTCTGTGGT CGTGTCBTBG TCCTCTGTGG TG'TTGGBGT TTCCBTCCCG GCTTCTCTCT GGTTCCBBGG GB-3' (FRAG. NO:1809) (SEQ. ID NO:1820) 5'-GGGCC CC-3' (FRAG. NO:1810) (SEQ. ID NO:1821) 5'-GGGGGCBGC-3' (FRAG. NO:1811) (SEQ. ID NO:1822) 5'-CCCGGCTTC-3' (FRAG. NO:1812) (SEQ. ID NO:1823) 5'-GTC TTT GTT TCT GGG CTC GTG CC-3' (FRAG. NO:1218) (SEQ. ID NO:1228) 5'-CCB TCC CGG CTT CTC TCT GGT TCC-3' (FRAG. NO:1219) (SEQ. ID NO:1229) 5'-GTC CTCTGT GGT GTT TGG-3' (FRAG. NO:1220) (SEQ. ID NO:1230) 5'-CCC TGC TTC CIT ITT CCT GTT-3' (FRAG. NO:1221) (SEQ. ID NO:1231) 5'-GAGGGGGCAG CAGTTGGGCC CCAAAGGCCC TCTCGTTCAC CITCTGGCAC GGAGTTGCAT CCCCATAGTC AAACTCTGTG GTCGT-3' (FRAG. NO:1222) (SEQ. ID NO:1232) 5'-GTCATAGTCCTCTGTGTGTTTGGAGTTCCATCCCGGCTTCTCTCTGGTTCCAAGGGA-3'(FRAG. NO:1223)(SEQ.ID NO:1233) 5'-GBGGGGGCBG CBGTTGGGCC CCBBBGGCCC TCTCGTTCBC CTTCTGGCBC GGBGTTGCBT CCCCBTBGTC BBBCTCTGTG GTCGTG-3' (FRAG. NO:1224) (SEQ. ID NO:1234) 5'-TCBTBGTCCTCTGTGGTGT7GGBGTT'CCBTCCCGGCTTCCTGGTTCCBBGGGB-3' (FRAG. NO:1225) (SEQ. ID NO:1235) RANTES Antisense Oligonucleotide Fragments 5'-GGGCBCGGGG CBGTGGGCGG GCBBTGTBGG CBBBGCBGCB GGGTGTGGTG TCCGBGGBBT BTGGGGBGGC BGBTGCBGGB GCGCBGBGGG CBGTBGCBBT GBGGBTGBCB GCGBGGCGTG CCGCGGBGBC CTTCBTGGTB CCTGTGGBGB GGCTGTCGGB GGGGGTGTGG TGTCCGCTTG GCGGTTCTTT CGGGTGTTTC TTCTCTGGGT TGGCCTGCTG CTCGTCGTGGT CGCTCCGCTC CCGGGTTCGT CTCGCTCTGT CGCCCCTCC TCCTTGTCG TGTTCCTCCC TTCCTTGCCT CT-3' (FRAG. NO: 1813) (SEQ. ID NO: 1824) 5'-GGGTTGGC-3' (FRAG. NO: 1814) (SEQ. ID NO: 1825) 5'-CGGGG CBG-3' (FRAG. NO: 1815) (SEQ. ID NO: 1826) 5'-CCCGGGTTCG-3' (FRAG. NO: 1816) (SEQ. ID NO: 1827) 5'-GGGTGTGGTG-3' (FRAG. NO: 1817) (SEQ. ID NO: 1828) 5'-GGGCBCGGGG CBGTGGGCGG GCBBTGTBGG CBBBGCBGCB GGGTGTGGTG TCCGBGGBBT BTGGGGBGGC BGBTGCBGGB GCGC-3' (FRAG. NO:1226) (SEQ. ID NO:1236) 5'-BGBGGGCBGTBGCBBTGBGGBTGBCBGCGBGGCGTGCCGCGGBGBCCTTrCBTGGTBCCTGTGGBGBGGCTGTCGGBGG-3' (FRAG. NO:1227) (SEQ. ID NO:1237) 5'-GGGTGTGGTGTCCGCTTGGCGGTTCTTCGGGTGTTTCCTCTGGGTTGGCCTGCTGCTCGTCGTGGTC-3' (FRAG. NO:1228) (SEQ. ID NO:1238) 5'-GCTCCGCTCCCGGGTTCGTCTCGCTCTGTCGCCCCTTCCCCTTGTCGTGTTCCTCCCCCTTGCCTCT-3' (FRAG. NO:1229) (SEQ. ID NO:1239) 5'-GGGTGTGGTGTCCG-3' (FRAG. NO:1230) (SEQ. ID NO:1240) WO 00/09525 PCT/US99/17712 EPI-109 185 5'-CTTGGCGGTTCTTCGGGTG-3' (FRAG. NO:1231) (SEQ. ID NO:1241) 5'-TTTCTTCTCTGGGTTGGC-3' (FRAG. NO:1232) (SEQ. ID NO:1242) 5'-CTGCTGCTCGTCGTGGTC-3' (FRAG. NO:1233) (SEQ. ID NO:1243) 5'-GCTCCGCTCCCGGGTTC-3' (FRAG. NO:1234) (SEQ. ID NO:1244) 5'-GTCTCGCTCTGTCGCCC-3' (FRAG. NO:1235) (SEQ. ID NO:1245) 5'-CTTCCTTCCTTGTC-3' (FRAG. NO:1236) (SEQ. ID NO:1246) 5'-GTGTTCCTCCCTTCCTTGCCTCT-3' (FRAG. NO:1237) (SEQ. ID NO:1247) 5'-GGGCBCGGGG CBGTGGGCGG GCBBTGTBGG CBBBGCBGCB GGGTGTGGTG TCCGBGGBBT BTGGGGBGGC BGBTGCBGGB GCGCBGBGGG CBGTBGCBBT GBGGBTGBCB GCGBGGCGTG CCGCGGBGBC CTTCBTGGTB CCTGTGGBGB GGCTGTCGGB GG-3' (FRAG. NO:1818) (SEQ. ID NO:1829) Human Muscarinic Acetvlcholine Receptor HM1* Nucleic Acid and Antisense Oligonucleotide Fragments 5'-GCTGCCCGGC GGGGTGTGCG CTTGGCGCTC CCGTGCTCGG TTCTCTGTCT CCCGGTCCCC CTTGCCTGGC GTCTCGGGCC TTCGTCCTCT TCCTCTTCTT CCTTCCGCTC CGTGGGGGCT GCTTGGTGGG GGCCTGTGCCT CGGGGTCCCG GGGCTTCTGG CCCTTGCCGT TCATGGTGGC TAGGTGGGGC GTTCBTGGTG GCTBGGTGGG GC-3' (FRAG. NO:1819) (SEQ. ID NO: 1830) 5'-GGTGGGGC-3' (FRAG. NO:1820) (SEQ. ID NO: 1831) 5'-GCCCGGCGGGG-3' (FRAG. NO:1821) (SEQ. ID NO: 1832) 5'-CGG GGC TTC TGG CCC-3' (FRAG. NO:1822) (SEQ. ID NO: 1833) 5'-GTT CBT GGT GGC TBG GTG GGG C-3' (FRAG. NO:1238) (SEQ. ID NO:1248) 5-GCT GCC CGG CGG GGT GTG CGC TTG GC-3' (FRAG. NO:1239) (SEQ. ID NO:1249) 5'-GCT CCC GTG CTC GGT TCT CTG TCT CCC GGT-3' (FRAG. NO:1240) (SEQ. ID NO:1250) 5'-CCC CCT TTG CCT GGC GTC TCG G-3' (FRAG. NO:1241) (SEQ. ID NO:1251) 5'-GCC TTC GTC CTC TTC CTC TTC TTC CTT CC-3' (FRAG. NO:1242) (SEQ. ED NO:1252) 5'-GCT CCG TGG GGG CTG CTT GGT GGG GGC CTG TGC CTC GGG GTC C-3' (FRAG. NO:1243) (SEQ. ID NO:1253) 5'-CGG GGC TTC TGG CCC TTG CC-3' (FRAG. NO:1244) (SEQ. ID NO:1254) 5-GTT CAT GGT GGC TAG GTG GGG C-3' (FRAG. NO: 1245) (SEQ. ID NO:1255) Human Muscarinic AcetyIcholine Receptor HM3* Nucleic Acid and Antisense Oligonucleotide Fragments 5'-GGG GTG GGT BGG CCG TGT CTG GGGGTT GGC CBT GTT GGT TGC CTCT TGG TGG TGC GCC GGG CGCG TCT TGG CTIT TCT TCT CCT TCG GGC CCT CGG GCC GGT GCT TGT GGGCT CCT CCC GGG CGG CCT CCC CGG GCG GGG GCT TCT TGGCG CTG GCG GGG GGG CCT CCTGCT CTG TGG CTG GGC GTT CCT TGG TGT TCT GGG TGGTGG CGG GCG TGG TGG CCT CTG TGGGGG CCC GCG GCT GCB GGG GTTG CCT GTC TGC TTC GTCCTT TGC GCT CCC GGG CCG CCGGG GTG GGT AGG CCG TGT CTG GGGGTT GGC CAT GTT GGT TGC CGGG CCC GCG GCT GCA GGG G-3' (FRAG. NO:1823) (SEQ. ID NO:1934) 5'-CCC GGG CGG-3' (FRAG. NO:1824) (SEQ. ID NO:1835) 5'-G GCG GGG GGG CC-3' (FRAG. NO:1825) (SEQ. ID NO:1836) 5'-CCC GGG CCG CC-3' (FRAG. NO: 1826) (SEQ. ID NO: 1837) 5'-GG CCG TGT-3' (FRAG. NO:1827) (SEQ. ID NO:1838) 5'-GGG GTG GGT BGG CCG TGT CTG GGG-3' (FRAG. NO:1246) (SEQ. ID NO:1256) 5'-GTT GGC CBT GTT GGT TGC C-3' (FRAG. NO:1247) (SEQ. ID NO:1257) 5'-TCT TGG TGG TGC GCC GGG C-3' (FRAG. NO:1248) (SEQ. ID NO:1258) 5'-GCG TCT TGG CTT TCT TCT CCT TCG GGC CCT CGG GCC GGT GCT TGT GG-3' (FRAG. NO:1249) (SEQ. ID NO:1259) 5'-GCT CCT CCC GGG CGG CCT CCC CGG GCG GGG GCT TCT TG-3' (FRAG. NO:1250) (SEQ. ID NO:1260) 5'-GCG CTG GCG GGG GGG CCT CCT CC-3' (FRAG. NO:1251) (SEQ. ID NO:1261) 5'-GCT CTG TGG CTG GGC GTT CCT TGG TGT TCT GGG TGG C-3' (FRAG. NO:1252) (SEQ. ID NO:1262) 5'-TGG CGG GCG TGG TGG CCT CTG TGG TGG-3' (FRAG. NO:1253) (SEQ. ID NO:1263) 5'-GGG CCC GCG GCT GCB GGG G-3' (FRAG. NO:1254) (SEQ. ID NO:1264) 5'-TTG CCT GTC TGC TTC GTC-3' (FRAG. NO:1255) (SEQ. ID NO:1265) 5'-CTT TGC GCT CCC GGG CCG CC-3' (FRAG. NO:1256) (SEQ. ID NO:1266) 5'-GGG GTG GGT AGG CCG TGT CTG GGG-3' (FRAG. NO:1257) (SEQ. ID NO:1267) 5'-GTT GGC CAT GTT GGT TGC C-3' (FRAG. NO:1258) (SEQ. ID NO:1268) 5'-GGG CCC GCG GCT GCA GGG G-3' (FRAG. NO:1259) (SEQ. ID NO:1269) Human Fibronectin* Antisense Oligonucleotide Fragments 5'-CGG TT CCT TTG CGG TC TTG GCC CGG GCT CCG GGT G CCC GCC CGC CCG CCG GCC GCC GC CCC GCC GGG CTG TCC CCG CCC CGC CCC GGC CCG GGG CGC GGG GG CGG CCC TCC CGC CCC TCT GGGCC GGC GCG GGC GTC GG CCG CTC GCG CCT GGG GTT CCC TCT CCT CCC CCT GTG C GCC TGC CTC TTG CTC TTCTGC GTC CGC TGC CTT CTC CC CTC TCC TCG GCC GTT GCC TGT GC TGT CCG TCC TGT CGC CCT TCC GTG GTG C TGT TGT CTC TTC TGC CCT C GGT GTG CTG GTG CTG GTG GTG GTG CCT CTG CCC GTG CTC GCCCTG CCT GGG CTG GCC TCT TCG GGT GTG GCT TTG GGG CTC TCT TGG TTG CCC TTI CTT CTC GTG GTG CCT CTC CTC CCT GGC TG GTC GT TGT CTG GGG TGG TGC TCC TCT CCC TTT CCC TGC TGG CCG TTT GT CCT GTT TTC TGT CTT CCT CT TTC CTC CTG TTT CTC CGT TTG GCT TGC TOC TTG CGG GGC TGT CTC C CTT GCC CCT GTG GGC TIT CCC TGG TCC GGT CTT CTC CTT GGG GGT C GCC CTT CTT GGT GGG CTGGCT CGT CTG TCT TTT TCC TTC C TGG GGG TGG CCG TTG TGG GCG GTG TGG TCC GCC T TGC CTC TGC TGG TCT ITC-3' (FRAG. NO:1828) (SEQ. ID NO: 1839) 5'-GGCCCGGGC-3' (FRAG. NO:1829) (SEQ. ID NO: 1840) 5'-GCCGGCGCGGGCG-3' (FRAG. NO:1830) (SEQ. ID NO:1841) 5'-GCCTGGGCT'GGCC-3' (FRAG. NO:1831) (SEQ. ID NO: 1842) 5'-GGGGG TGGCCG-3' (FRAG. NO:1832) (SEQ. ID NO: 1843) 5'-GG GGG TGG CCG TTG TGG GCG G-3' (FRAG. NO:1833) (SEQ. ID NO: 1844) 5'-CGG TTT CCT TTG CGG TC-3' (FRAG. NO:1260)(SEQ. ID NO:1270) WO 00/09525 PCTIUS99/17712 EPI-109 186 5'-TTG GCC CGG GCT CCG GGT G-3 (FRAG. NO:1261)(SEQ. ID NO:1271) 5'-CCC GCC CGC CCG CCG GCC GCC GC-3' (FRAG. NO:1262)(SEQ. ID NO:1272) 5'-CCC GCC GGG CTG TCC CCG CCC CGC CCC-3' (FRAG. NO:1263)(SEQ. ID NO:1273) 5'-GGC CCG GGG CGC GGG GG-3' (FRAG. NO:1264)(SEQ. ID NO:1274) 5'-CGG CCC TCC CGC CCC TCT GG-3' (FRAG. NO:1265)(SEQ. ID NO:1275) 5'-GCC GGC GCG GGC GTC GG-3' (FRAG. NO:1266)(SEQ. ID NO:1276) 5'-CCG CTC GCG CCT GGG GTT CCC TCT CCT CCC CCT GTG C-3' (FRAG. NO:1267)(SEQ. ID NO:1277) 5'-GCC TGC CTC TTG CTC 'IC-3' (FRAG. NO:1268)(SEQ. ID NO:1278) 5'-TGC GTC CGC TGC CTT CTC CC-3' (FRAG. NO:1269)(SEQ. ID NO:1279) 5'CTC TCC TCG GCC GTT GCC TGT GC-3' (FRAG. NO:1270)(SEQ. ID NO:1280) 5'-TGT CCG TCC TGT CGC CCT TCC GTG GTG C-3' (FRAG. NO:1271)(SEQ. ID NO:1281) 5'-TGT TGT CTC TTC TGC CCT C-3' (FRAG. NO:1272)(SEQ. ID NO:1282) 5'-GGT GTG CTG GTG CTG GTG GTG GTG-3' (FRAG. NO:1273)(SEQ. ID NO:1283) 5'-CCT CTG CCC GTG CTC GCC-3' (FRAG. NO:1274)(SEQ. ID NO:1284) 5'-CTG CCT GGG CTG GCC TCT TCG GGT-3' (FRAG. NO:1275)(SEQ. ID NO:1285) 5'-GTG GCT TTG GGG CTC TCT TGG TTG CCC TTT-3' (FRAG. NO:1276)(SEQ. ID NO:1286) 5'-CTT CTC GTG GTG CCT CTC CTC CCT GGC TTG GTC GT-3' (FRAG. NO:1277)(SEQ. ID NO:1287) 5'- TGT CTG GGG TGG TGC TCC TCT CCC-3' (FRAG. NO:1278)(SEQ. ID NO:1288) 5'-M CCC TGC TGG CCG T GT-3' (FRAG. NO:1279)(SEQ. ID NO:1289) 5'-CCT GTT TTC TGT CiT CCT CT-3' (FRAG. NO:1280)(SEQ. ID NO:1290) 5'-TTC CTC CTG TT CTC CGT-3' (FRAG. NO:1281)(SEQ. ID NO:1291) 5'-TTG GCT TGC TGC TTG CGG GGC TGT CTC C-3' (FRAG. NO:1282)(SEQ. ID NO:1292) 5'-CTT GCC CCT GTG GGC M CCC-3' (FRAG. NO:1283)(SEQ. ID NO:1293) 5-TGG TCC GGT CT CTC CT GGG GGT C-3' (FRAG. NO:1284)(SEQ. ID NO:1294) 5'-GCC CTT CT GGT GGG CTG-3' (FRAG. NO:1285)(SEQ. ID NO:1295) 5'-GCT CGT CTG TCT TMT TCC TTC C-3' (FRAG. NO:1286)(SEQ. ID NO:1296) 5'-TGG GGG TGG CCG TTG TGG GCG GTG TGG TCC GCC T-3' (FRAG. NO:1287)(SEQ. ID NO:1297) 5'-TGC CTC TGC TGG TCT TTC-3' (FRAG. NO:1288)(SEQ. ID NO:1298) Human Interleukin-1 (IL-1) Nucleic Acid and antisense Oligocnucleotide Fragments 5'-AAGCTTCTAC CCTAGTCTGG TGCTACACTT ACATTGCTTA CATCCAAGTG TGGTTATTTC TGTGGCTCCT GTTATAACTA TTATAGCACC AGGTCTATGA CCAGGAGAAT TAGACrGGCA TTAAATCAGA ATAAGAGATT TTGCACCTGC AATAGACCIT ATGACACCTA ACCAACCCCA TATTTACAA TTAAACAGGA ACAGAGGGAA TACTTTATCC AACTCACACA AGCTGTITC CTCCCAGATC CATGCITIT TGCGTTTATT AITITI1AGA GATGGGGGCT TCACTATGIT GCCCACACTG GACTAAAACT CTGGGCCTCA AGTGATTGTC CTGCCTCAGC CTCCTGAATA GCTGGGACTA CAGGGGCATG CCATCACACC TAGTCATTT CCTCTAMA AAATATACAT GGCTTAAACT CCAACTGGGA ACCCAAAACA TTCATTTGCT AAGAGTCTGG TGTTCTACCA CCTGAACTAG GCTGGCCACA GGAATTATAA AAGCTGAGAA ATTCTAAT AATAGTAACC AGGCAACATC ATTGAAGGCT CATATGTAAA AATCCATGCC TCCTI1TCTC CCAATCTCCA TTCCCAAACT TAGCCACTGG TTCTGGCTGA GGCCTTACGC ATACCTCCCG GGGCTTGCAC ACACCTTCTT CTACAGAAGA CACACCITGG GCATATCCTA CAGAAGACCA GGCTTCTCTC TGGTCCTTGG TAGAGGGCTA CITACTGTA ACAGGGCCAG GGTGGAGAGT TCTCTCCTGA AGCTCCATCC CCTCTATAGG AAATGTGTTG ACAATATTCA GAAGAGTAAG AGGATCAAGA CTTCTITGTG CTCAAATACC ACTGTTCTCT TCTCTACCCT GCCCTAACCA GGAGCTTGTC ACCCCAAACT CTGAGGTGAT TTATGCCTTA ATCAAGCAAA CTTCCCTCIT CAGAAAAGAT GGCTCATT CCCTCAAAAG TTGCCAGGAG CTGCCAAGTA TTCTGCCAAT TCACCCTGGA GCACAATCAA CAAATTCAGC CAGAACACAA CTACAGCTAC TATTAGAACT ATTATTATTA ATAAATTCCT CTCCAAATCT AGCCCCTTGA CTTCGGATTT CACGATTTCT CCCTTCCTCC TAGAAACTTG ATAAGTTTCC CGCGCTTCCC T111CTAAG ACTACATGTT TGTCATCTTA TAAAGCAAAG GGGTGAATAA ATGAACCAAA TCAATAACTT CTGGAATATC TGCAAACAAC AATAATATCA GCTATGCCAT CTTTCACTAT TTTAGCCAGT ATCGAGTTGA ATGAACATAG AAAAATACAA AACTGAATTC TTCCCTGTAA ATTCCCCGTT TTGACGACGC ACTTGTAGCC ACGTAGCCAC GCCTACTTAA GACAATACA AAAGGCGAAG AAGACTGACT CAGGCTTAAG CTGCCAGCCA GAGAGGGAGT CATTCATTG GCGTTTGAGT CAGCAAAGGT ATTGTCCTCA CATCTCTGGC TATTAAAGTA ITTCTGTTG TTGTITTCT CTTTGGCTGT TTTCTCTCAC ATTGCCTTCT CTAAAGCTAC AGTCTCTCCT TTCIT1TCTT GTCCCTCCCT GGTGTGTAT GTGACCTAGA ATTACAGTCA GATTTCAGAA AATGATTCTC TCATTGCT GATAAGGACT GATCGTT ACTGAGGGAC GGCAGAACTA GTTTCCTATG AGGGCATGGG TGAATACAAC TGAGGCTTCT CATGGGAGGG AATCTCTACT ATCCAAAATT ATTAGGAGAA AATTGAAAAT TTCCAACTCT GTCTCTCTCT TACCTCTGTG TAAGGCAAAT ACCTTAITCT TGTGGTGTTT TGTAACCTC TTCAAACTTT CATTGATTGA ATGCCTGTTC TGGCAATACA TITAGGTTGGG CACATAAGGA ATACCAACAT AAATAAAACA TTCTAAAAGA AGTTTACGAT CTAATAAAGG AGACAGGTAC ATAGCAAACT AATTCAAAGG AGCTAGAAGA TGGAGAAAAT GCTGAATGTG GACTAAGTCA TTCAACAAAG 'TITCAGGAA GCACAAAGAG GAGGGGCTCC CCTCACAGAT ATCTGGATTA GAGGCTGGCT GAGCTGATGG TGGCTGGTGT TCTCTGTTGC AGAAGTCAAG ATGGCCAAAG TTCCAGACAT GT'1TGAAGAC CTGAAGAACT GTTACAGGTA AGGAATAAGA TTTATCTCT GTGATTTAAT GAGGGTTTCA AGGCTCACCA GAATCCAGCT AGGCATAACA GTGGCCAGCA TGGGGGCAGG CCGGCAGAGG TTGTAGAGAT GTGTACTAGT CCTGAAGTCA GAGCAGGTTC AGAGAAGACC CAGAAAAACT AAGCATTCAG CATGTTAAAC TGAGATTACA TTGGCAGGGA GACCGCCAT TTAGAAAAAT TAITITIGAG GTCTGCTGAG CCCTACATGA ATATCAGCAT CAACTTAGAC ACAGCCTCTG TTGAGATCAC ATGCCCTGAT ATAAGAATGG GTTACTGG TCCATTCTCA GGAAAACTTG ATCTCATrCA GGAACAGGAA ATGGCTCCAC AGCAAGCTGG GCATGTGAAC TCACATATGC AGGCAAATCT CACTCAGATG TAGAAGAAAG GTAAATGAAC ACAAAGATAA AATTACGGAA CATATTAAAC TAACATGATG TTTCCATTAT CTGTAGTAAA TACTAACACA AACTAGGCTG TCAAAATT GCCTGGATAT TFTACTAAGT ATAAAITATG AAATCTGTIT TAGTGAATAC ATGAAAGTAA TGTGTAACAT ATAATCTATT TGGTTAAAAT AAAAAGGAAG TGCTTCAAAA CCTTTC=TT CTCTAAAGGA GCTTAACATT CTTCCCTGAA CTTCAATTAA AGCTCTTCAA TTTGTTAGCC AAGTCCAATT TTTACAGATA AAGCACAGGT AAAGCTCAAA GCCTGTCTTG ATGACTACTA ATTCCAGATT AGTAAGATAT GAA'1TACTCT ACCTATGTGT ATGTGTAGAA GTCCITAAAT TTCAAAGATG ACAGTAATGG CCATGTGTAT GTGTGTGACC CACAACTATC ATGGTCATTA AAGTACATTG GCCAGAGACC ACATGAAATA ACAACAATTA CATTCTCATC ATCTTATT GACAGTGAAA ATGAAGAAGA CAGTTCCTCC ATTGATCATC WO 00/09525 PCT/US99/17712 EPI-109 187 TGTCTCTGAA TCAGGTAAGC AAATGACTGT AATTCTCATG GGACTGCTAT TCTTACACAG TGGTCTTC ATCCAAAGAG AACAGCAATG ACTTGAATCT TAAATACTTT TGTTACCC TCACTAGAGA TCCAGAGACC TGTCITCAT TATAAGTGAG ACCAGCTGCC TCTCTAAACT AATAGTTGAT GTGCATTGGC TrCTCCCAGA ACAGAGCAGA ACTATCCCAA ATCCCTGAGA ACTGGAGTCT CCTGGGGCAG GCTTCATCAG GATGTTAGTT ATGCCATCCT GAGAAAGCCC CGCAGGCCGC TTCACCAGGT GTCTGTCTCC TAACGTGATG TGTTGTGGTT GTCTTCTCTG ACACCAGCAT CAGAGGTTAG AGAAAGTCTC CAAACATGAA GCTGAGAGAG AGGAAGCAAG CCAGCTGAAA GTGAGAAGTC TACAGCCACT CATCAATCTG TGT'TATTGTG TTTGGAGACC ACAAATAGAC ACTATAAGTA CTGCCTAGTA TGTCTTCAGT ACTGGCTTTA AAAGCTGTCC CCAAAGGAGT ATTTCTAAAA TATTGAGC ATTGTTAAGC AGATTTAA CCTCCTGAGA GGGAACTAAT TGGAAAGCTA CCACTCACTA CAATCATTGT TAACCTAT AGTTACAACA TCTCATTITr GAGCATGCAA ATAAATGAAA AAGTCITCCT AAAAAAATCA TC'IT11ATC CTGGAAGGAG GAAGGAAGGT GAGACAAAAG GGAGAGAGGG AGGGAAGCCT AATGAAACAC CAGTTACCTA AGACCAGAAT GGAGATCCTC CTCACTACCT CTGTTGAATA CAGCACCTAC TGAAAGAACT TrCATTCCCT GACCATGAAC AGCCTCTCAG CTTCTG'TT CCTrCCTCAC AGAAATCCTT CTATCATGTA AGCTATGGCC CACTCCATGA AGGCTGCATG GATCAATCTG TGTCTCTGAG TATCTCTGAA ACCTCTAAAA CATCCAAGCT TACCTTCAAG GAGAGCATGG TGGTAGTAGC AACCAACGGG AAGGTTCTGA AGAAGAGACG GTrGAGTTTA AGCCAATCCA TCACTGATGA TGACCTGGAG GCCATCGCCA ATGACTCAGA GGAAGGTAAG GGGTCAAGCA CAATAATATC TTCITITAC AGTTAAGC AAGTAGGGAC AGTAGAAT17 AGGGGAAAAT TAAACGTGGA GTCAGAATAA CAAGAAGACA ACCAAGCATT AGTCTGGTAA CTATACAGAG GAAAATTAAT TTATCCTT CTCCAGGAGG GAGAAATGAG CAGTGGCCTG AATCGAGAAT ACT7GCTCAC AGCCATTATT TCTTAGCCAT ATTGTAAAGG TCGTGTGACT TTAGCCTIT CAGGAGAAAG CAGTAATAAG ACCACTTACG AGCTATGTTC CTCTCATACT AACTATGCCT CCTTGGTCAT GTrACATAAT CITTCGTGA TTCAGTTrCC TCTACTGTAA AATGGAGATA ATCAGAATCC CCCACTCATT GGATTGTTGT AAAGATTAAG AGTCTCAGGC TMTACAGACT GAGCTAGCTG GGCCCTCCTG ACTGTTATAA AGATTAAATG AGTCAACATC CCCTAACTTC TGGACTAGAA TAATGTCTGG TACAAAGTAA GCACCCAATA AATGTTAGCT ATTACTATCA T7ATTATTAT TA7ITTATT iTITITITG AGATGGAGTC TGGCTCTGTC ACCCAGGCTG GAGTGCAGTG GCACAATCTC GGCTCACTGC AAGCTCTGCC TCCTGGGTTC ATGCCATTCT CCTGCCTCAG CCTCCCGAGT AAGCTGGGAA TACAGGCACC CGCCACTGTT CCCGGCTAAT TTTTGTATr TTAGTAGAG ACGGAGTC ACCGTGGTCT CCATCTCCTC GTGATCCACC CACCTTGGCC TCCCAAAGTG CCGGGATTAC AGGCGTGAGC CACCGCGCCC GGCCTATTAT TATTATTATT ACTACTACTA CTACCTATAT GAATACTACC AGCAATACTA ATTTATTAAT GACTGGATTA TGTCTAAACC TCACAAGAAT CCTACCTTCT CATTTACAT AAAAGGAAAC TAAGCTCATr GAGATAGGTA AACTGCCCAA TGGCATACAT CTGTAAGTGG GAGAGCCTCA AATCTAATTC AGTTCTACCT GAGTAAAAAA ATCATGGTT CTCCTCCATC CCTITACTGT ACAAGCCTCC ACATGAACTA TAAACCCAAT ATrCCTGT TTAAGATAAT ACCTAAGCAA TAACGCATGT TCACCTAGAA GGITAAAA TGTAACAAAA TATAAGAAAA TAAAAATCAC TCATATCGTC AGTGAGAGTT TACTACTGCC AGCACTATGG TATGTCCT TAAAATCTFT GCTATACACA TACCTACATG TGAACAAATA TGTCTAACAT CAAGACCACA CTATTACAA CTTTATATCC AGCIl-CTT ACTTAGCAAT GTATFGAGGA CATITTAGAG TGCCCGTI1T TCACCATTAT AAGCAATGCA ACAATGAACA TCTGTATAAA TAAATATTCA TCTCTCAC CC TATTTC CTTAGAATAT ATTCCTAGAA GTAGAATTTC CCAGAGCCAT GAGGATTTGT GACGCTATTG ATATGTGCCA CTITGCACTC TCTGTGACAT ATATAATTAT TITTAATGCA TTCA1T1T TCTCAGAGTG CATTCGTTTG AAAACATAGA CGGGAAATAC TGGTAGTCTT CCTTGTCAGT TAGAAACACC CAAACAATGA AAAATGAAAA AGTTGCACAA ATAGTCTCTA AAAACAATGA AACTATTGCC TGAGGAATTG AAGTTAAAA AGAAGCACAT AAGCAACAAC AAGGATAATC CTAGAAAACC AGTTCTGCTG ACTGGGTGAT TTCACTTCTC T7TGCTTCCT CATCTGGATT GGAATATTCC TAATACCCCC TCCAGAACTA TTCCCTGT TTGTACTAGA CTGTGTATAT CATCTGTGTT TGTACATAGA CATTAATCTG CACTTGTGAT CATGGTTA GAAATCATCA AGCCTAGGTC ATCACCTITr AGCTTCCTGA GCAATGTGAA ATACAACTTT ATGAGGATCA TCAAATACGA ATTCATCCTG AATGACGCCC TCAATCAAAG TATAATTCGA GCCAATGATC AGTACCTCAC GGCTGCTGCA TTACATAATC TGGATGAAGC AGGTACATTA AAATGGCACC AGACATTTCT GTCATCCTCC CCTCCTCA TACTTATT TATTATTTC AATCTTCTG CTTGCAAAAA ACATACCTCT TCAGAGTTCT GGGTEGCACA ATTCTTCCAG AATAGCTTGA AGCACAGCAC CCCCATAAAA ATCCCAAGCC AGGGCAGAAG GTTCAACTAA ATCTGGAAGT TCCACAAGAG AGAAGTTrCC TATCTGAG AGTAAAGGGT TGTGCACAAA GCTAGCTGAT GTACTACCTC TTTGGTTCTr TCAGACATTC TTACCCTCAA TTTAAAACT GAGGAAACTG TCAGACATAT TAAATGATTT ACTCAGATTT ACCCAGAAGC CAATGAAGAA CAATCACTCT CC'TTAAAAA GTCTGTrGAT CAAACTCACA AGTAACACCA AACCAGGAAG ATC'TATTA TCTCTGATAA CATATTTGTG AGGCAAAACC TCCAATAAGC TACAAATATG GCTTAAAGGA TGAAG'TTAG TGTCCAAAAA CITITATCAC ACACATCCAA TTCATGGC GGACATGT TAGTCAAC AGTATACATA TITTCAAAGG TCCAGAGAGG CAAT=GCA ATAAACAAGC AAGACiTITF CTGATTGGAT GCACTTCAGC TAACATGCTT TCAACTCTAC ATTTACAAAT TAITTGTGT TCTAT1111C TACTTAATAT TAICTGCA AT=TTCCCAA TATGACATC GTGTATGTAT TTGCCAT=TT TAATATCACT AGACAATTCA ATCAGGTTGC TACGTrGGTC CCTTGGGTTT ACTCTAAATA GCTTGATTGC AAATATCT GTATATATTA TrG'1T1-iC TCCTATCTG TAATTTCT GAGCACATCC CAAAGAGGAA TGCCTAGATC AATGGGCACA AATAATTTGA CAGCTCTTAT TAAACATFAT TCTGTAAGTA AAAACTGAAC TACTITICAG TATCACTAGC AACATATGAG TGTATCAGCT TCCTAAACCC CTCCATGTTA GGTCATTATG AACTrATGAT CTAACAAATT ACAGGGTCTT ATCCCACTAA TGAAATTATA AGAGATTCAA CACTTATTCA GCCCCGAAGG ATTCATTCAA CGTAGAAAAT TCTAAGAACA TTAACCAAGT ATTACCTGC CTAGTGAGTG TGGAAGACAT TGTGAAGGAC ACAAAGATGT ATAGAAT7CC ATTCCTGACT TCCAGGTATT TACACCATAG GTGGGGACCT AACTACACAC ACACACACAC ACACACACAC ACACACACAC ACCATGCACA CACAATCTAC ATCAACACTT GAlTTATAC AAATACAATG AATTTACT CIT7IiGGTT CCTCTTCA CCAGTGAAAT TTGACATGGG TGCTrATAAG TCATCAAAGG ATGATGCTAA AATTACCGTG ATTCTAAGAA TCTCAAAAAC TCAATTGTAT GTGACTGCCC AAGATGAAGA CCAACCAGTG CTGCTGAAGG TCAGTTGTCC TGTCTCCA ACTTACCTTC ATACATCT CATATGTTTG TAAATAAGCC 'CAATAGGCAG ACACCTCTAA CAAGGTGACA CTGTCCTCTT TCCTTCCTAC CACAGCCCCC ACCTACCCAC CCCACTCCCA TTGATTCCAG AGGCGTGCCT AGGCAGGATC TATGAGAAAA TATAACAGAG AGTAAGAGGA AAATTACCT7 CTTCTTT CCTTCCCTG CCTGACCTTA TTCACCTCCC ATCCCAGAGC ATCCATTTAT TCCATTGATC TTTACTGACA TCTATTATCT GACCTACACA ATACTAGACA ITAGGACAAT GTGGCCTGCC TCCAAGAAAC TCAAATAAGC CAACTGAGAT CAGAGAGGAT TAATCACCTG CCAATGGGCA CAAAGCAACA AGCTGGGAGC CAAGTCCCAA AATGGGGCCT GCTGCTTCCA GTTCCCCTCT CTCTGCATTG ATGTCAGCAT TATCCTTCGT CCCAGTCCTG TCTCCACTAC CACTTCCCC CTCAAACACA CACACACACA ACAGCCTTAG ATGTTCTC CACTGATAAG TAGGTGACTC AAFGTAAG TATATAATCC AAGACCTTCT ATTCCCAAGT AGAATATG TGCCTGCCTG TGCITITCTA CCTGGATCAA GTGATGTCTA CAGAGTAGGG CAGTAGCTTC ATTCATGAAC TCATTCAACA AGCATATTC ACTGAGAGCC TTGTATT CAGGCATAGT GCCAACAGCA GTGTGGACAG WO 00/09525 PCT/US99/1 7712 EPI-109 188 TGGTGCATCA AAGCCTCTAG TCTCATAGAA CT7AGTCTFC TGGAGGATAT GGAAAACAGA CAACCCAAAC AACCAACAAA AGAGCAAGAT GCTGCAAAAA AAAAAAAAAT GAATAGGGTG CTAAGATAGA GAAAAGTGGG AGAGTGCTAT TTAGACAAAG TGGTAAAAAC AAAGCCCCrr GTGAGATGAG AGCTGCCGAC AGAGGGGGCG GGTCATGGfl GTGGGTT=T GGGTAGGACA TITCAGAGGAG GGGGCGGGTC GTGGTrGTGG GTITIGGGT AGGACATTCA GAGGAGGGGG CGGGTCGTGG T17GTGGG TT'FGGGTAGGA CATT1CAGAGG AGGGGGCGGG TCGTGGT7GT GGGTf=GG GTAGGACAT7 CAGAGGAGGG GGCGGGTCGT GGrTGTGGGT TInrGGGACA TTCAGAGGAG TCTGAATGCA CCCAGGCCTA CAACTrCAAG ATGGTAAAGG ACAGCTCCAA GGATCAGAAG AAGCATT= GGAACTGGGG CA=FTGAGA AGGAGGAAAA ATATGCAGAG ACTAGTGCTT GCAGAGCTrG CA=fGGATr TCAMhGAGG TACAATGAAA ACCCATI1AAT GGGTITCACA CAGTGCAATG GCCTGACCTC ACTTATATr CCTAAAATAG AAAACAGATC AGAAGGAAGG CAATAGAGAA GCAGAAAGTC CAATGAGGAG GTITCACAGC AGTCATGGGG GTGGGGTAAG GAAAAGAAGT GGAAAGAAAC AGACAGAATT GGGTFrATAT TTGGACIATAG AACCAACAGA AGGAAGAGGA GAAACAACAT TTACTGAGAA GGGAAAAAGT AGGAGAGGAA TAGGYTrTGGG AAATAAATCC TGCTGACATT GGAAACCCCA AGGAAGCCTC AAAAGTATAT TFACTrGCTr TAGAMTAAA AGAATAGGAA AGAAGCATCT CAACT]7GGAA M~GAAATCT A'ITTICCAT AAAAGTArITG FrAAATTCTA CTCATACTCA CAAGAAAAGT ACATTCTAAA GAGTATATTG AAAGAGTITA CTGATATACT TAGGAATFI GTGTGTATGT GTGTGTGTGT ATGTGTGTGT GTGTG'TJAA CCT-'CAATT1G 'FrGACTrAAA TACTGAGATA AATGTCATC-I AAATGCTAAA TFrGAT17CCC AAAGGTATGA n1TGTrCACT TGGAGATCAA AATGITJAGG GGGCTTAGAA TCACTGTAGT GCTCAGATI17 GATGCAAAAT GTCTAGGCC TATGTrGAAG GCAGGACAGA AACAATG'TrT CCCTCCTACC TGCCTGGATA CAGTAAG.ATA CTAGTGTCAC TGACAATCTr CATAACTAAT TTAGATCTCT CTCCAATCAA CTAAGGAAAT CAACrCTTAT TAATAGACTG GGCCACACAT CTACTAGGCA rGjTAATAAAT GCT7GCTGAA TGAACAAATG AATGAAGAGC CTATAGCATC ATGITACAGC CATAGTCCTA AAGTGGTGTT TC7.CATGAAG GCCAAATGCT AAGGGArrGA GCT-rCAGTCC TFI=CTAAC ATCTTGTTCT CTAACAGAAT TCTCTrCIT TCT7CATAGG AGATGCCTGA GATACCCAAA ACCATCACAG GTAGTGAGAC CAACCTCCTC 'Tr=CTGGG AAACTCACGG CACTAAGAAC TA'T7CACAT CAGT7GCCCA TCCAAACTTG TIAT[GCCA CAAAGCAAGA CTACTGGGTG TGCT~rGGCAG GGGGGCCACC CTCTATCACT GACI=CAGA TACTGGAAAA CCAGGCGTAG GTCTGGAGTC TCACTI'GTCT CACTGTGCA GTGTTGACAG TrCATATGTA CCATGTACAT GAAGAAGCTA AATCCTIAC TGYFTAGTCAT TTGCTGAGCA TGTACTGAGC CITGTAATrC TAAATGAATG M~ACACTCT TTGTAAGAGT GGAACCAACA CTAACATATA ATGTTGTrAT TTAAAGAACA CCCTATAT17 TGCATAGTAC CAATCA=IT AA'FFATrATT =~CATAACA AITIAGGAG GACCAGAGCT ACTGACTATG GCT-ACCAAAA AGACTCTACC CATATTACAG ATGGGCAAAT TAAGGCATrAA GAAAACTAAG AAATATGCAC AATAGCAGTr GAAACAAGAA GCCACAGACC TAGGA'IMCA TGAMrCATr TCAACTGMT GCCT'GCT 7TAAG FTGC TGATGAACTC ITyAATCAAAkT ACYCATAAGTTf TCTGGGACCT CAGTMTATC ArI'rCAAAA TGGAGGGAAT AATACCTAAG CCT7CCTGCC GCAACAGMr TTrATGCT-AA TCAGGGAGGT CATI=GGTA AAATACTTCT CGAAGCCGAG CCTCAAGATG AAGGCAA-AGC ACGAAATGvTT ATITITAAT TATTATrrAT ATATGTA=, ' ATAAATATAT TTAACGATAAT TATAATATAC TATA'TrATG GGAACCCCTI7 CATCCrCIGA GTGTnACCAG GCATCC[CCA CAATAGCAGA CAGTGTT~rC TGGGATAAGT AAGT17GATT TCATIAATAC AGGGCATITT (3CTCCAAGnI GTGCTTATCC CATAGCCAGG AAACTCTGCA 'ITCrAGTAC-T TGGGAGACCT GTAATCATAT AATAAATGTA CATTAATTAC CrrGAGCCAG TAATrGGTCC GATCT7GAC TCTT1GCCA TTAAACTTAC (7(oGGCA17C TTG7I-rCATr CAAT'rCCACC TGCAATCAAG TCCTACAAGC TAAAATrAGA TGAACTCAAC TT7GACAACC ATGAGACCAC TGTTATCAAA A=TTC=I1 CTGGAATGTA ATCAATGTTTr CTrCT7AGGTT CTAAAAATTG TGATCAGACC ATix.ATGTTAC A'FrA'rATCA ACA.ATAGTGA TTGATAGAGT GITATCAGTC ATFAACT7AAAT AAAGCIrrGCA ACAAAATTCT CTGACACATA G11'ATrCATh7 GICCIT7AATCA rTT.ACT7 GCATGGTAAT TAGGGACAAA TGGTAAATGT TTACATAAAT XATrGTA717 AGTGTTALCT7 TATP-AAATCA AACCAAGA~r TrATA'TFI TTCTCCTCTTF TGTTAGCTGC CAGTALTGCAT AAATGGCA'rT AAGAATGATA ATArl'rCCGG GTTrCAC'FIAA AGCTCATATr ACACATACAC AAAACATGTG TTCCCATCTr TATACAAA(Zr CACACATACA GAGCTACArI' AAAAACAACT AA'IAGGCCAG GCACGGTGGC TCAGACCTGT AATCCCAGCA CTTTGGAGG ACCAACCTCT TCGAGGCACA AGGCACAACA GGCTGCTCTG GGAT'rCTCTr CAGCCAATCT TCATTGCTCA AGTlGTCTCAA (3CAGCCATGG CAGAAGTACC TGAGcrCGCC AGTGAAATGA TGGCT-rATTA CAGTGGCAAT GAGGATGACT T('rCIlTrTGA AGCTGATGGC CCrAAACAGA TGAAGTGCTC CT7CCAGGAC CTGGACCTCT GCCCTCTGGA TGGCGGCATC CAGCTAC:GAA TC-TCCGACCA CCACTACAGC AAGGG=rrCA GGCAGjGCCGC GTCAGTTGTr GTGGCCATGG ACAAGCTGAG GAAGATGCTG CiTTCCCTGCC CACAGACCT7 CCAGGAGAAT GACCTGAGCA CCTCTTCC CTTCATCTI GAAGAAGAAC CTATM.'IC CGACACATCGG GArAACciAGG CTr'ATCTGCA CGATGCACCT GTACGATCAC TGAACTGCAC GCTCCGGGAC TCACAGCAAA AAAGCTTrGrr GATGTCTGGT CCATATGAAC TGAAAGCTCT. CCACCTCCAG GGACAGGATA TGGAGCAACA AGTGGTG1TC TCCATGTCCT TTGTACAAGG AGAAGAAAGT AATGACAAAA TACCTGTGGC CTGGGCCTC AAGGAAAAGA ATCTGTACCT GTCCTGCGTG TTGAAAGATG ATAAG'CCCAC TC7ACAGC%'G GAGAGTGTAG ATCCCAAAAA 7rACCCAAAG AAGAAGAT[GG AAAAGCGAT1 TGTCfTCAAC AAGATAGAAA TCAATAACA Ak GCTiGGAAMT GAGTCTG CCC AG~rCCCCAA CTGCTACATC AGCACC7CITC AAGCAGAAAA CkTI7yCCCGTC T7CCTGGGAG GGACCAAAGG CGGCCAGGAT ATAACTGACT TCACCATGCA ATnTGTGTCT 'rCCTAAAGAG AUjCIGTACCC AGAGAGTCCT GTGCTGAATG TGGA.CTCAAT CCCTAGGGCT GCCAGAAAGG GAACAGAAAG G I I i IGAGT ACC.GC(-tATAG CCTGCGACYP CCTC(;TrGTCT' ACACCAATGC CCAACTrGCCF GCCPTAGGGT AG-TGCTAAGA (IGA rcrCCTG TCCATCAGCC AGGACAGTCA GCTCTCT'CCT- TTCAGGGCCA ATCCCCAGCC CTT=GTTGjA GCCAGGCCTC TCTrCACC-TCT CCrACTCACT TAAAGCCCGC CTGACA'JAAA CCACGGCCAC A'IMGGTrCT AAGJAAACCCT C-TGTCATI'CG CTCCCACA'Fr CTGATGAGCA ACCGCTTCCC T.4TITA'IrA 'FTrAMTT TG1TTG71TT A'I1TCA7rGGT CTAA'IMAr CAAAGGGGGC AACJAAGTAGC AGTGTCTGTA AAAGACICCTA GTI=rAATA GCTATGriAAT CAA TCAA FF TGGACTGGTG TGCTC.T MTT AAATCAAGTC CT1rAATrAA GAC-T(GAAAAT ATATAAGCTC AGAri'ATTTA AATGGGAATA T'.rAAATG AGCAAtiTATC ATACTGTTCA ATGGTTCFGA AATAAACLTC TCTGAAG AGAAAGAAAG AGACGAGAGAA AGAAAAGAAA GAGGAAGGAA GGAAGGAAGG AAGAAAGACA GGCTrCTGAGG AAGGTGGCAG mIICC-..'ACAAC GGGAGAACCA GTGGTrAAT-i TGCAAAGTGG A rCCTrGTGGA GGCANNCAGA GGAGTCCCCT AGGCCACCCA GACALGGGCTT flAGCTATCT GCAGG(.'CAGiA CA(CA.AATTT7 CACGAGGGCT CAGT'JTTAGG AATGGAFFAT GGCTrATCAA AiTCACAGGA AACTAACP.T( 'FIGiAACAGCT.TTrAGA'TrC CTGTGGAAAA TATAAC-rA.C TAAAGATGGA G~rCrCfGTGA CTGACTCCTG ATATCAAGAT ACTrGGGAGCC AAAUTAA.AAA TCP.GAAUiGCr CnfGAGAG CAAGTCCATG AAATGCTCIT7 FTrCCCACAG TAGAACC7AT ITCCCTCGTG TCTC'A.AATAC TTGCACACJAG GCTCACT-CCC TIGGATAATG CAGAGCGAGC AC(3ATACCT7G GCACATACTA AITTGAATAA AATGCTGTCA AATrCCCATT CACCCAT[CA A'ICAGCAAAC TCTATCICAC CTGrAATGTAC ATGCCAGGCA CTG'rGC-TAGiA C'TTG:C CAA AAAGATITCA GTI7CCTGGA GGAA CCAGGA GGGCAAGGT7 T( AACTCAGT GCTAI AAGAA GIGTTACAGiG CTC-GACACOiG TGGCTCACGC CVGfAATCCC AACAIrGGG AGGCCGAGCYC rjGGJCAGATCA CAACGTCAGG WO 00/09525 PCT/US99/1 7712 EPI-109 189 AGATCGAGAC CATCCTGc3CT AACATGGTGA AACCCTGTCT CTACTAAAAA TACAAAAAAT TAGCCGGGCG TrGGCGGCAG GTGCCTGTAG TCCCAGCTGC TGGGGAGGCT GAGGCAGGAG AATGGTGTGA ACCCGGGAGG CGGAACT7GC AGGGGGCCGA GATCGTGCCA CTGCACTCCA GCCTGGGCGA CAGAGTGAGA CTCTGTCTCA AAAAAAAAAA AAAAGTGTTA TGATGCAGAC CTGTCAAAGA GGCAAAGGAG GGTGTrCCTA CACTCCAGGC ACTGT7CATA ACCTGGACTC TCATflCATTC TACAAATGGA GGGCTCCCCT GGGCAGATCC CTGGAGCAGG CAC1TGCTG GTGTCTCGGT TAAAGAGAAA CTGATAACTC T7GGTATrAC CAAGAGATAG AGTCTCAGAT GGATATTCTT ACAGAAACAA TAT7CCCACT TITCAGAGTr CACCAAAAAA TCA=I]AGG CAGAGCTCAT CTGGCATTGA TCTGGTrCAT CCATGAGATr GGCTAGGGTA ACAGCACCTG GTCTTGCAGG GT]TGTGTGAG CTrATCTCCA GGGTrGCCCC AACTCCGTCA GGAGCCTGAA CCCTGCATAC CGTATGTTCT CTFGCCCCAGC CAAGAAAGGT CAATI=CTC CTCAGAGGCT CCrGCAATT1G ACAGAGAGCT CCCGAGGCAG AGAACAGCAC CCAAGGTAGA GACCCACACC CTCAATACAG ACAGGGAGGG CTATrGGCCC TTCATTGTAC CCATIATCC ATCTGTAAGT GGGAAGATTC CTAAACTTAA GTACAAAGAA GTGAATGAAG AAAAGTATGT GCATGTATAA ATCTGTGTGT C=CCAC'= GTCCCACATA TACTAAA'IM AAACATTCTT CTAACGTGGG AAAATCCAGT A'IIAATGT GGACATCAAC TGCACAACGA T~rGTCAGGAA AACAATGCAT A=TGCATGG TGATACAYI GCAAAATGTG TCATAGTG CTACTCCT7G CCCTCCATG AACCAGAGAA 'rTATCrCAGT TITATrAGTCC CCTCCCCTAA GAAGC'rTCCA CCAATACTCT 'rTCCCc= CC'I=AACTT GAT7GTGAAA TCAGGTATTC AACAGAGAAA TTCTCAGCC TCCTAC11CT GC'TITGAAA GCTATAAAAA CAGCGAGGGA GAAACTGGCA GATACCAAAC CTCITrCGAGG CACAAGGCAC AACAGGCTGC TCTGGGAflC T=TCAGCCA ATCTFCATTG CrCAAGTATG ACPTAATCT TCCT7ACAAC TAGGTGCTAA GGGAGTCTCT CTGTCTCTCT GCCTC1TGT GTGTATGCAT ATTCTCTCTC TcrurcrrT TCT=CTCTG TCTCTCCTCT CCT-rCCTCTC TGCCTCCTCT CTCAGCTI= TGCAAAAATG CCAGGTGTAA TATAATGCI ATGACTCGGG AAATA17CTG GGAATGGATA CTGCTrATCT AACAGCTGAC ACCCTAAAGG ITrAGTGTCAA AGCCTCTGCT CCAGCTCTCC TAGCCAATAC ATrGCTAGTr GGGGTGGT TTAGCAAATG CITCTCTA GACCCAAAGG A=C~cr= CACACA7TCA 7rCATTACT CAGAGATCAT T~T=GCAT GACTGCCATG CACTGGATGC TGAGAGAAAT CACACATGAA CGTAGCCGTC ATGGGGAAGT CACrCATIT CTCCT=ITA CACAGGTGTC TGAAGCAGCC ATGGCAGAAG TACCTGAGCT CGCCAGTGAA ATGATGGCT A'I1ACAGGTC AGTGGAGACG CTGAGACCAG TAACATGAGC AGGTCTCCTC M~CAAGAGT AGAGTGTTAT CTGTGCT7GG AGACCAGATIT 7rrCCCCTAA ATTGCCT=f TCAGTGGCAA ACAGGGTGCC AAGTAAATCT GA'ITrAAAGA CTAC1TCCC ATTACAAGTC CCTCCAGCCT TGGGACCTGG AGGCTATCCA GATGTGTTGT TGCAAGGGCT TCCTGCAGAG GCAAATGGGG AGAAAAGAT17 CCAAGCCCAC AATACAAGGA ATCCCI=GC AAAGTGTGGC TrTGGAGGGAG AGGGAGAGCT CAGAT=FAG CTrGACTCrGC TGGGCTAGAG GT7AGGCCTC AAGATCCAAC AGGGAGCACC AGGGTGCCCA CCTGCCAGGC CTAGAATCTG CC717CTGGAC TGTrC7GCGC ATATCACTGT GAAACT7GCC AGGTGTTCA GGCAGCTIG AGAGGCAGGC TG=~GCAGT Tfr=rATGAA CAGTCAAGTC TFGTACACAG GGAAGGAAAA ATAAACCTGT TI'AGAAGACA TAAT-rGAGAC ATGTCCCTGT TITACA GTGGCAATGA GGATGAC=G T7C'TTrGAAG CTGATGGCCC TAAACAGATG AAGGTAAGAC TATGGGTh17A ACTCCCAACC CAAGGAAGGG CTCTAACACA GGGAAAGCrC AAAGAAGGGA GTrCTGGGCC A=1IGATGC CATGGTAMT TG7MTAGAA AGACITAAC CTCTCCAGT GAGACACAGG CTGCACCACT TGCTGACCTG GCCACTTGGT CATCATATCA CCACAGTCAC TCACTAACGT TGGTGGTGGT GGCCACACTr GGTGGTGACA GGGGAGGAGT AGTGATAATG 'I1CCCATI1C ATAGTAGGAA GACAACCAAG TCTTCAACAT AAMArGATr ATCCT1TAA GAGATGGKI17 CAGCCTATGC CAATCACTTG AGTTAAACTC TGAAACCAAG AGATGAT=~ GAGAACTrAAC ATATGTCTrAC CCCTI=GAG TAGAATAG'T TTTGCTACC TGGGGTGAAG CFATAACAA CAAGACATAG ATGATATAAA CAAAAAGATG AATTGAGACT TGAAAGAAAA CCA'rrCACrr GCTG'I=GAC CTGACAAGT CATTACCC GC'=GGACC TCATCTGAAA AATAAAGGGC TGAGCTGGAT GATCTCTGAG ATTCCAGCAT CCTGCAACCT CCAGTTCTGA AATATI=CA GTTGTAGCTA AGGGCAMIG GGCAGCAAAT GGTCA'TTF CAGACTCATC CI1FACAAAGA GCCATGTTAT A'rrCCTGCTG TCCCTIrCTGT 'IMATATGAT GCITCAGTAGC =TCCTAGGT GCCCAGCCAT CAGCCTAGCT AGGTCAGTlG TGCAGGTrGG AGGCAGCCAC 1T=CTCTGG =TIATIA TTCCAGTI7G TGATAGCCTC CCCTAGCCTC ATAATCCAGT CCTCAATCTT GTTAAAAACA TA1TMT=A GAAGTIIAA GACTGGCATA ACTrCT7GGC TGCAGCTGTG GGAGGAGCCC ATI7GGCITGT CTGCCTrGGCC TTTGCCCCCC ATTGCCTCTT CCAGCAGCTT GGCTCTGCTC CAGGCAGGAA A'ITCTCTCCT GCTCAACT= C'ITGTGCA CTITACAGGTC TCTIAACTG TCTICAAGC CTIGAACCA TTATCAGCCT TAAGGCAACC TCAGTGAAGC C=AATACGG AG=~CTCTG AATAAGAGGA AAGTGGTAAC AMCACAAA AAGTACTCTC ACAc3GAMhG CAGAATGCCT ATGAGACAGT G'FrATGAAAA AGGAAAAAAA AGAACAGTGT AGAAAAN11TG AATAC-I7GCT GAGTGAGCAT AGGTGAATGG AAAATGTTAT GGTCATCTGC ATGAAAAAGC AAATCATAGT GTGACAGCAT TAGGGATACA AAAAGATATA GAGAAGGTAT ACATGTATGG TGTAGGTGGG GCATGTACAA AAAGATGACA AGTAGAATCG GGATIA~rC TAAAGAATAG CCTGTAAGGT GTCCAGAAGC CACArrClTAG TCTI'GAGTCT GCCTCTACCT GCTGTGTGCC =TGAGTACA CCCTAACCT CCTGAGC1hT CAGAGAGGGA TAATCTIT A=F~A=I~ AT1TA=IF crirG=r G=FTG=FT GTITATGAG ACAGAGTCTC ACTCTGFIGC CCAGGCTGGA GTGCAGTGGT ACAATC=GG =TACTGCAT CCTCCACCTC CTGAGTTCAA GCGAT~cTCC FrCCTCAGTC TCCTGAATAG CTAGGATrAC AGGTGCACCC CACCACACCC AGCTAA=FT TGTATTIA GTAGAGAAGG GGTIT7CGCCA TGTrGGCCAG GCTGGrrrG AAGTCCTGAC CTAAATGAT7 CATCCACCTC GGCT7CCCAA AGTGCTGGGA TF1ACAGGCAT GAGCCACCAC GCCTGGCCCA GAGAGGGATG ATCITAGAA GCTCGGGATr C'=CAAGCC C'=CCTCCT CTCrGAGCT TCTACTCTCT GATGTCAAAG CATGGTTCCT GGCAGGACCA CCTCACCAGG CTCCCTCCCT CGC7CTCTCC GCAGTGCTCC TrCCAGGACC TGGACCTCTG CCCTCTGGAT GGCGGCATCC AGCTACGAAT CTCCGACCAC CACTACAGCA AGGGCrTCAG GCAGGCCGCG TCAGTrGT7G TGGCCATGGA CAAGCTGAGG AAGATGCTGG3 TTCCCrGCCC ACAGACCTC CAGGAGAATG ACCTGAGCAC Crr=CCC 'FrCATC=rG AAGAAGGTAG TFAGCCAAGA GCAGGCAGTA GATCTCCACT TGTGTCCTCT TGGAAGTCAT CAAGCCCCAG CCAACTCAAT TCCCCCAGAG CCAAAGCCCT T[AAAGGTAG AAGGCCCAGC GGGGAGACAA AACAAAGAAG GCTGGAAACC. AAAGCAATCA TCTCTTAGT GGAAACTATT CT7AAAGAAG ATC17TGATGG CTACTGACAT TGCAACTCC CrCACrCTI CTCAGGGGCC 'T7CACTrAC AT7GTCACCA GAGGTTCGTA ACCTCCO7GT GGGCTAGTGT TATGACCATC ACCATTTAC CTAAGTAGCT CTGTTGCTCG GCCACAGTGA GCAGTAATAG ACCTGAAGCT GGAACCCATG TCTAATAGTG TCAGGTCCAG TGTTCITAGC CACCCCACTC CCAGCT7CAT CCCTACTGGT GTTGTCATCA GAC'=GACC GTATATGCTC AGGTGTCCTC CAAGAAATCA AA'IIGCCA CCTrCGCCTCA CGAGGCCTGC C=CFGA'rr TrATACCTAA ACAACATGTG CTCCACATI1 CAGAACCTAT C'FrCTTCGAC ACATGGGATA ACGAGG=TA TGTGCACGAT GCACCTGTAC GATCACTGAA CTGCACGCrC CGGGACTCAC AGCAAAAAAG CTGGTGATG TCTGGTCCAT ATGAACTGAA AGCTCITCCAC CTCCAGGGAC AGGATATGGA GCAACAAGGT AAATGGAAAC ATCCTGGTr CCCTGCCTGG CCTCCTGGCA G=TGcTAAT TCTCCATGITr TrAAACAAAG TAGAAAGT7A AMrAAGGCA AATGATCAAC ACAAGTGAAA AAAAATATrA AAAAGGAATA TACAAACI= GGTCCTAGAA ATGGCACA'FF TGATTGCACT GGCCAGTGCA 'TIrGTrAACA GGAGTGTGAC CCTGAGAAAT TAGACGGCTC WO 00/09525 PCT/US99/1 7712 tIi-109 190 AAGCACTCCC AGGACCATGT CCACCCAAGT CTCT7GGGCA TAGTGCAGTG TCAATTCTrC CACAATATGG GGcTCATTrGA TGGACATGGC CTAACTGCCT GTGGGTTCTC TCTTCCTGTT GTFGAGGCTG AAACAAGAGT GCTGGAGCGA TAATGTGTCC ATCCCCCTCC CCAGTCTrCC CCCCTTGCCC CAACATCCGT CCCACCCAAT GCCAGGTGGT TCCTTGTAGG GAAA'IIAC CGCCCAGCAG GAACrrATAT CX1TCCG3CrG TAACGGGCAA AAG !TCAAG TGCGGTGAAC CCATCAflAG CTGTGGTGAT CTGCCTGGCA TCGTGCCACA GTAGCCAAAG CCTCTGCACA GGAGTGTGGG CAACTAAGGC TGCTGA='~ GAAGGACAGC CTCACTCAGG GGGAAGCTAT F7GCTCTCAG CCAGGCCAAG AAAATCCTGT 17=I~GGAA TCGGGTAGTA AGAGTGATCC CAGGGCCTCC AA1rGACACT GCTGTGACTG AGGAAGATCA AAATGAGTGT c-CTTT=GG AGCCAC TC CCAGCTCAGC CTCTrCCTCTC CCAGITTCTT CCCATGGGCT ACTCTCTGT7 CCTGAAACAG FTCTGGTGCC TGAM1CrGG CAGAAGTACA GCT'rCACCTC nI7CcI=CC TrCCACAT7G ATCAAG77GT TCCGCTCCTG TGGATGGGCA CArrGCCAGC CAGTGACACA ATGGCICCT TCCrrCCrC CICAGCA77 TAAAATGTAG ACCCrCFnTC ATTCTCCGTT CCTACTGCTA TGAGGCTCTG AGAAACCCTC AGGCC1TGA GGGGAAACCC TAAATCAACA AAATGACCCTr GCTATTGTCT GTGAGAAGTC AAGTrATCCT GTGTCTrAGG CCAAGGAACC TCACTGTGGG TTCCCACAGA GGCTACCAAT TACATGTATC CTACTCTCGG GGCTAGGGGT TGGGGTGACC CTGCATGCTG TGTCCCTAAC CACAAGACCC CCTTC1TCT TCAGTGGTGT TCTCCATGTC C1TGTACAA GGAGAAGAAA GTAATGACAA AATACCTGTG G1C=~GGGCC TCAAGGAAAA GAATCTGTAC CTGTCCTGCG TGTrGAAAGA TGATAAGCCC ACTCTACAGC TGGAGGTAAG TGAATGCTAT GGAATGAAGC CCTCTCAGC CTCCTGCTAC CA=~A'FrCC CAGACAAT'rC ACCTTCTCCC CGCCCCCATC C~rAGGAAAA GCI'GGGAACA GGTO~rAT1rG ACAAGT1TG CATrAATGTA AATAAA IMA ACATAATFI TAACTGCGTG CAACCTI'CAA TCCTGCTGCA GAAAATTAAA TCAT=IGCC GATGTrAITrA TGTCCTACCA TAGTrACAAC CCCAACAGAT TATATATTGT TAGGGCTGCT CTCA'TTrGAT AGACACCFrG GGAAATAGAT GAC11?AAAGG GTCCCA FrAT CACGTCCACT CCACTCCCAA AATCACCACC ACTATCACCT CCAG=CIrT CAGCAAAAGC TrCA'rrTCCA AG'FrGATGTC ATTCTAGGAC CATAAGGAAA AATACAATAA AAAGCCCCTG GAAACTAGGT ACrrCAAGAA GCTCTAGCT AA=hFCACC CCCCCAAAAA AAAAAAATrC TCACCrACAT TATGCTCCTC AGCA ITGGC ACTAAGTIT AGAAAAGAAG AAGGGCTCT TTAATAATCA CACAGAAAGT TGGGGGCCCA GITACAACTC AGGAGTCTGG CrCCTGATCA TGTGACCTGC TCGTCAGMl CCrGGC CAACCCAAAG AACATCI=C CCATAGGCAT C1TGTCCCT TGCCCCACAA AAATrCT7CT 7rCT='TCG CTGCAGAGTG TAGATCCCAA AAATTACCCA AAGAAGAAGA TGGAAAAGCG ATr7GTCT7C AACAAGATAG AAATCAATAA CAAGCTGGAA TTGAGTCTG CCCAGTrCCC CAACTGGTAC ATCAGCACCTr CTCAAGCAGA AAACATGCCC GTCT7CCTGG GAGGGACCAA AGGCGGCCAG GATATAACTG ACTITCACCAT GCAA IT7GTG TC=CCTAAA GAGAGCrGTA CCCAGAGAGT CCTGTGCrGA ATGTGGACTC AATCCCTAGG GCTGGCAGAA AGGGAACAGA AAGG'ITITG AGTACGGCTA TAGCCTGGAC TITCCTGTrG TCTACACCAA TGCCCAACTG CCrGCCrTAG GGTAGTGCTA AGAGGATCTC CTGTCCATCA GCCAGGACAG TCAGCTCT CCT=CAGGG CCAATCCCCA GCCCITIGT TGAGCCAGGC CTCTCTCACC TCTCCTACTC ACrrAAAGCC CGCCTGACAG AAACCACGGC CACAM~GGT TCTAAGAAAC CCTCTGTCAT TCGCTCCCAC ATTCTGATGA GCAACCGCIT CCCTA'IMAT TrATrTA=~ GTITTGTIGT TITFGATCAT TGGTCTAA'Tr TAYrCAAAGG GGGCAAGAAG TAGCAGTGTC TGTAAAAGAG CCTAGTfIT AATAGCrATG GAATCAAT7C AA ITGGACT GGTGTGCTCT =WAAATCA AGTCCTTrAA TrAAGACTGA AAATATATAA GCTCAGA FTA 7ITTAAATGGG AATATI7ATA AATGAGCAAA TATCATACTG 7rCAATGG F7 CTGAAATAAA CTrCACTGAA GAAAAAAAAA AAAGGGTCTC TCCTGATCAT TGACTGTCTG GATTGACACT GACAGTAAGC AAACAGGCTG TGAGAGT7CT TGGGACTAAG CCCACTCCTC A F7GCTGAGT GCTGCAAGTA CCTAGAAATA TCCTrGGCCA CCGAAGACTA TCCTCCTCAC CCATCCCCTIT TA=ICGTTG TrCAACAGAA GGATAT~rCAG TGCACATCTG GAACAGGATC AGCTGAAGCA CTGCAGGGAG TCAGGACrGG TAGTAACAGC TACCATGATr TATCTATCAA TGCACCAAAC ATCTGTTGAG CAAGCGCTAT GTACTAGGAG CTGGGAGTAC AGAGATGAGA ACAGTCACAA GTCCCTCCTC AGATAGGAGA GGCAGCTAGT TATAAGCAGA ACAAGGTAAC ATGACAAGTA GAGTAAGATA GAAGAACGAA GAGGAGTAGC CAGGAAGGAG GGAGGAGAAC GACATAAGAA TCAAGCCTAA AGGGATAAAC AGAAGATI1C CACACATGGG CTGGGCCAAT TGGGTGTCGG TFrACGCCTGT AATCCCAGCA C1TGGGTGG CAGGGGCAGA AAGATCGCIT GAGCCCAGGA GT7CAAGACC AGCCTGGGCA ACATAGTGAG ACTCCCATCT CrACAAAAAA TAAATAAATA AATAAAACAA TCAGCCAGGC ATGCTGGCAT GCACCTGTAG TCCTAGCrAC TrGGGAAGCT GACACTGGAG GATrGCTTGA GCCCAGAAGT TCAAGACTGC AGTGAGCTTA TCCGT7GACC TGCAGGTCGA C ACAAACCI= TCGAGGCAAA AGGCAAAAAA GGCTGCTCTG GGATrCTC= CAGCCAATCT TCAATGCTCA AGTGTCTGAA GCAGCCATGG CAGAAGTACC TAAGCTCGCC AGTGAAATGA TGGCTATTA CAGTGGCAAT GAGGATGACT TGTrC'=GA AGCTGATGGC CCTAAACAGA TGAAGTGCTC CTTrCCAGGAC CTGGACCTCT GCCCTGGA TGGCGGCATC CAGCTrACGAA TCTCCGACCA CCACTACAGC AAGGGCITCA GGCAGGCCGC GTCAGTrGT7 GTGGCCATGG ACAAGCTGAG GAAGATGCTG GTrCCCTGCC CACAGACCT7 CCAGGAGAAT GACCrGAGCA CCITCX=CC CrCATCrI GAAGAAGAAC CTATCIT=C CGACACATGG GATAACGAGG CTTATGTGCA CGATGCACCT GTACGATCAC TGAACTGCAC GCTCCGGGAC TCACAGCAAA AAAGCrrGGT GATGTCTGGT CCATATGAAC TGAAAGCTCT CCACCTCCAG GGACAGGATA TGGAGCAACA AGTGGTG'ITC TCCATGTCCT TTGTACAAGG AGAAGAAAGT AATGACAAAA TACCrGTGGC CT7GGGCCTC AAGGAAAAGA ATCTGTACCT GTCCTGCGTG T7GAAAGATG ATAAGCCCAC TCTACAGCTG GAGAGTGTAG ATCCCAAAAA 7rACCCAAAG AAGAAGATGG AAAAGCGMTT TGTCTCAAC AAGATAGAAA TCAATAACAA GCTGGAATI7r GAGTCTGCCC AGTI'CCCCAA CTGGTACATC AGCACCrCTC AAGCAGAAAA CATGCCCGTC T'TCCTGGGAG GGACCAAAGG CGGCCAGGAT ATAACTGACT TCACCATGCA A1TGTGTCT TCCTAAAGAG AGCTGTACCC AGAGAGTCCT GTGCTGAATG TGGACTCAAT CCCTAGGGCT GGCAGAAAGG GAACAGAAAG GTFITGAGT ACGGCTATAG CCTGGACI= CCTGTrGTCT ACACCAATGC CCAACrGCCT GCCTrAGGGT AGTGCTAAGA GGATcTCCTG TCCATCAGCC AGGACAGTCA GCTCrCTCCT TTCAGGGCCA ATCCCAGCCC TIIG TrGAG CCAGGCCTCT CTCACCTCTC CrFACTCACTT AAAGCCCGCC TGACAGAAAC CAGGCCACAT '1GGITFCTA AGAAACCCTC CTCTGTCATF CGCTCCCACA TrCTGATGAG CAACCGCTrC. CCArATT TATITA1TrG TrrGTTTGTT TrGA~rrCATr GGTCTAAIM ATTCAAAGGG GGCAAGAAGT AGCAGTGTCT GTAAAAGAGC CTAG~TTA ATAGCTATGG AATCAATTCA A'ITrGGACTG GTGTGCTCTC TT-rAAATCAA GTCC=rAAT TAAGACTGAA AATATATAAG CTCAGATTAT 'rTAAATGGGA ATATrATAA ATGAGCAAAT ATCATACTGT TCAATGGTTC TCAAATAAAC T11CACT CTGGCAGGAG TAGCAGCTGC CCCTTGGCGC GACTGCTGGA GCCGCGAACT AGAGAAACAC AGACACGCCT CATAGAGCAA CGGCGTCTCT CGGAGCGTGG AGCCCGCCAA GCTCGAGCTG AGCTTCGCT TGCCGTCCAC CACTGCCCAC ACTGTCGTI GCTGCCATCG CAGACCTGCT GCrGA=~CC ATCCCTCTGG ATCCGGCAAG GGCCTGCGAT MTGACAATG TCAAGA FITA CCGTATATCC CTGTTT GGATACACCA GTGACGTCCA cTrCTAGAAG ACAAAG ITAT A FrACrrAAA CAACCAAAGA TATGAAACTA TCCATGAAGA ACAATA FrAT CAATACACAG CAGTCI=G TAACCATGCC CAATGTGATr GTACCAGATA TTGAAAAGGA AATACGAAGG ATGGAAAATG GAGCATGCAG CTCCTI=CT GAGGATGATG ACAGTGCCT7C TACATCTGAA GAATCAGAGA ATGAAAACCC TCATGCAAGG GG FrCCITA GTrATAAGTC WO 00/09525 PCT/US99/1 7712 EPiI-109 191 ACTCAGAAAG GGAGGACCAT CACAGAGGGA GCAGTACCTG CCTGGTGCCA rrGCCATIT TAATGTGAAC AACAGCGACA ATAAGGACCA GGAACCAGAA GAAAAAAAGA AAAAGAAAAA AGAAAAGAAG AGCAAGTCAG ATGATAAAAA CGAAAATAAA AACGACCCAA AGAAGAAGAT GGAAAAGCGA ATGGCCAAAG 1TCCAGACAT GInrGAAGAC CTGAAGAACT GTTACAGTGA AAATGAAGAA GACAG77CCT CCATrGATCA TCTGTCTCTG AATCAGAAAT CCTCTrATCA TGTAAGCTAT GGCCCACTCC ATGAAGGCTG CATGGATCAA TCTGTGTCTC TGAGTATCTC TGAAACCTCT AAAACATCCA AGCTTACCTTr CAAGGAGAGC ATGGTGGTAG TAGCAACCAA CGGGAAGGT7 CTGAAGAAGA GACGGflrGAG TITAAGCCAA TCCATCACTG ATGATGACCT GGAGGCCATC GCCAATGACT CAGAGGAAGA AATCATCAAG CCTAGGTCAG CACCI1TAG CT'rCC7GAGC AATGTGAAAT ACAAC1TAT GAGGATCATC AAATACGAAT TCATCCTGAA TGACGCCCTC AATCAAAGTA TAAT'rCGAGC CAATGATCAG TACCTCACGG CTGCrGCA~Fr ACATAATCTG GATGAAGCAG TGAAAMTGA CATGGGTGCT TATAAGTCAT CAAAGGATGA TGCTAAAAT ACCGTGATrC TAAGAATCTC AAAAACTCAA UTGTATGTGA CTGCCCAAGA TGAAGACCAA CCAGTGCTGC TGAAGGAGAT GCCTGAGATA CCCAAAACCA TCACAGGTAG TGAGACCAAC CTCCTrcTrCr TCTGGGAAAC TCACGGCACT AAGAACTATT TCACATCAGT TGCCCATCCA AAC'I1G'TIA rrGCCACAAA GCAAGACTAC TGGGTGTGCT TGGCAGGGGG GCCACCCTCT ATCACTGACT TrCAGATACT GGAAAACCAG GCGTAGGTCTr GGAGTCTCAC T'rGTCTCACT TGTGCAGTGT TGACAGT7CA TATGTACCAT GTACATGAAG AAGCTAAATC =TACTGYF AGTCATITGC TGAGCATGTA CTGAGCCFrG TAAUU]rAAA TGAATGTrA CACTCITGT AAGAGTGGAA CCAACACTAA CATATAATGT TGTYrAMTAA AGAACACCCT ATATI=GCA TAGTACCAAT CA=IIAA'rr AT17ATrCVFC ATAACAATI TAGGAGGACC AGAGCTACTG ACTATGGCTA CCAAAAAGAC TCTACCCATA TrACAGATGG GCAAATrAAG GCATAAGAAA ACrAAGAAAT ATGCACAATA GCAGTTGAAA CAAGAAGCCA CAGACC7AGG An7~CATGAT 1TCATICA-A CTGT=GCCT TCTGCrI=A AGTrGCTGAT GAACTCTFAA TCAAATAGCA TAAG71-TCTG GGACCTCAGT MIATCA1T TCAAAATGGA GGGAATAATA CCTAAGC=T CCTGCCGCAA CAGTTFA TGCrAATCAG GGAGGTCATT TTGGTAAAAT ACrCGAA GCCGAGCC~rC AAGATGAAGG CAAAGCACGA AATGTATr 'TrAATrAT7 A'IMATATAT GTATIATAA ATATAMTAA GATAATrATA ATATACTATA 'ITATGGGAA CCCCTrCATC CTCTGAGTGT GACCAGGCAT CCTCCACAAT AGCAGACAGT G=FTICTGGG ATAAGTAAGT TTGAnI7CAT TAATACAGGG CA TTGGTC CAAGITrGTGC 'ITATCCCATA GCCAGGAAAC TCTGCATTCT AGTACT'rGGG AGACCTGTAA TCATATAATA AATGTACA'T AATTACCT7G AGCCAGTAAT TGGTCCGATC MFGACrT'r 'ITGCCA ITAA ACTTACCTGG GCATTCTTGT ITrCAIrCAAT TCCACCTGCA ATCAAGTCCT ACAAGCTAAA ATrAGATGAA CTCAAC1TG ACAACCATAG ACCACTGTTA TCAAAA=II CTITCTGGA ATGTAATCAA TGMTrCr AGGTTCTAAA AAT17GTGATC AGACCATAAT GTrACATI7AT TATCAACAAT AGTGATTGAT AGAGTGrrAT CAGTCATAAC TAAATAAAGC TrGCAAGTGA GGGAGTCATr TCA'ITGGCGT TTGAGTCAGC AAAGAAGTCA AG AGC7GCCAGC CAGAGAGGGA GTCA'T7CAT TGGCG'TrGA GTCAGCAAAG AAGTCAAGAT GGCCAAAGTr CCAGACATGT TrGAAGACCT GAAGAACTGT TACAGTGAAA ATGAAGAAGA CAGTrCCTCC ATrGATCATC TGTCTCTGAA TCAGAAATCC T7CrATCATG TAAGCrATGG CCCACTCCAT GAAGGCTGCA TGGATCAATC TGTGTCTCTG AGTATCTCTG AAACCTCTAA AACATCCAAG CF17ACMI1CA AGGAGAGCAT GGTGGTAGTA GCAACCAACG GGAAGG'TTCT GAAGAAGAGA CGGTTGAGTr TAAGCCAATC CATCACTGAT GATGACCTGG AGGCCATCGC CAATGACTCA GAGGAAGAAA TCATCAAGCC TAGGTCATCA CCFITAGCT TCCTGAGCAA TGTGAAATAC AACT I IATGA GGATCATCAA ATACGAATTC ATCCTGAATG ACGCCCTCAA TCAAAGTATA ATFCGAGCCA ATGATCAGTA CC7CACGGCT GCTGCATTAC ATAATCTGGA TGAAGCAGTG AAAT'rTGACA TGGGTGC17A TAAGTCATCA AAGGATGATG CTAAAATTAC CGTGA IWTA AGAATCTCAA AAACTCAAT7 GTATGTGACT GCCCAAGATG AAGACCAACC AGTGCTGCTG AAGGAGATGC CTGAGATACC CAAAACCATC ACAGGTAGTG AGACCAACCT CCTCTrCTrC TGGGAAACTC ACGGCACTAA GAACTATFIC ACATCAGTrG CCCATCCAAA CT7GMIAT7 GCCACAAAGC AAGACTACTG GGTGTGCTrG GCAGGGGGGC CACCCTCTAT CACTGA=rr CAGATACTGG AAAACCAGGC GTAGGTCTGG AGTCTCACT7 GTCTCACTG TGCAGTGTTG ACAGTTCATA TGTACCATGT ACATGAAGAA GCTAAATCCT T7ACTGTAG TCA'ITGCTG AGCATGTACT GAGCCTrGTA ATTCTAAATG AATG'IMACA CTCTTGTAA GAGTGGAACC AACACTAACA TATAATGTTG TrA1TIrAAAG AACACCCTAT ATITGCATA GTACCAATCA 'ITMAAT7AT TATITCTTCAT AACAA1TTA GGAGGACCAG AGCTACTGAC TATGGCTACC AAAAAGACTC TACCCATAT7 ACAGATGGGC AAATrAAGGC ATAAGAAAAC TAAGAAATAT GCACAATAGC AGTCGAAACA AGAAGCCACA GACCTAGGAT TTICATGA717 CATITCAACT GTTTGCC'F7C TGC1TFAAG TTGCTGATGA ACTCT'TAATC AAATAGCATA AGMrCTGGG ACCTCAGIT TATCATITC AAAATGGAGG GAATAATACC TAAGCCTTCC TGCCGCAACA GT-T1TATG CTAATCAGGG AGGTCATI= GGTAAAATAC 'ITCTCGAAGC CGAGCCTCAA GATGAAGGCA AAGCACGAAA TG FJA TT TAA'FrATTAT ITATATATGT A'T17ATAAAT ATATTTAAGA TAATFATAAT ATACTATATT TATGGGAACC C=TCATCCT CTGAGTGTGA CCAGGCATCC TCCACAATAG CAGACAGTGT ITCTGGGAT AAGTAAGMF GATnTCATFTA ATACAGGGCA T1TGGTCCA AGTFGTGCT7 ATCCCATAGC CAGGAAACTC TGCAT~cTAG TACTTGGGAG ACCTGTAATC ATATAATAAA TGTACATTAA TJTACCITGAG CCAGTAATTG GTCCGATCT7 TGACTC F1T GCCATrAAAC FrACCTGGGC ArCrrTG CATTCAA FrC CACCTGCAAT CAAGTCCTrAC AAGCFAAAAT TAGATGAACT CAACI=GAC AACCATGAGA CCACTGTrAT CAAAAUITC TITCTGGAA TGTAATCAAT G=~CT-rCTA GGTrCTAAAA ATTGTGATCA GACCATAATG 'rrACATrATr ATCAACAATA GTGATTGATA GAGTGT7ATC AGTCATAACT AAATAAAGCT TGCAACAAAA TCICTG-3' (FRAG. NO:_)(SEQ. ID NO:2517) 5'-AAGCrAC CCTAGTCTGG TGCTACACfl ACATTG=TA CATCCAAGTG TGGflrAMTC TGTGGCTCcTr GTrATAACrA T-rATAGCACC AGGTCTrATGA CCAGGAGAAT TAGACTGGCA TrAAATCAGA ATAAGAGATT 7rGCACCTGC AATAGACCI17 ATGACACCTA ACCAACCCCA rrATr7ACAA TTAAACAGGA ACAGAGGGAA TAC1TATCC AACTCACACA AGCTGTI=C CTCCCAGATC CATGC1TIT TGCG'TrATT ATTIAGA GATGGGGGCT TCACTATGTT GCCCACACrG GACTAAAACT CTGGGCCTCA AGTGATrGTC CTGCCTCAGC CTCCTrGAATA GCTGGGACTA CAGGGGCATG CCATCACACC TAGTrCATff CCTrCTAMfA AAATATACAT GGCTTAAACT CCAACTGGGA ACCCAAAACA 'TCAITrGCT AAGAGTCTGG TGTrCTACCA CVrGAACTAG GCTGGCCACA GGAA711ATAA AAGCTGAGAA ATr=ITAAT AATAGTAACC AGGCAACATC ATTGAAGGCT CATATGTAAA AATCCATGCC TrCCTICTC CCAATCTCCA TCCCAAACT TAGCCACTGG 'FrCTGGCTGA GGCCTTACGC ATACCTCCCG GGGCI1rGCAC ACACCTITCIT CTACAGAAGA CACACCTrGG GCATATCCTA CAGAAGACCA GGCTTcrTC TGGTCCTGG TAGAGGGCTA CTITACTGTA ACAGGGCCAG GGTGGAGAGT TCTCTCCTGA AGCTCCATCC CCTCTATAGG AAATGTG'FFG ACAATATTCA GAAGAGTAAG AGGATCAAGA C'ITr=GTG CTCAAATACC ACTG TCTCT TCTCTACCCT GCCCTAACCA GGAGCTTGTC ACCCCAAACT CTGAGGTGAT TTATGCCTA ATCAAGCAAA CTICCCTCI1 CAGAAAAGAT GGCTCA=1I CCCTCAAAAG TTGCCAGGAG CTGCCAAGTA TTCTGCCAAT TCACCCTGGA GCACAATCAA CAAATrCAGC CAGAACACAA CTACAGCTAC TATTAGAACT ATTATrATrA ATAAATTCCT CTCCAAATCT AGCCCCTrGA CTITCGGAITT CACGA'rCT CCCITCCTCC TAGAAACT7G ATAAGTITCC CGCGC'ITCCC FTICrAAG ACTACATG11 TGTCATCTrA WO 00/09525 PCT/US99/17712 tri-m0 192 TAAAGCAAAG GGGTGAATAA ATGAACCAAA TCAATAACTT CTGGAATATC TGCAAACAAC AATAATATCA GCTATGCCAT CTTCACTAT TTTAGCCAGT ATCGAGTTGA ATGAACATAG AAAAATACAA AACTGAATTC TTCCCTGTAA ATTCCCCGTT TTGACGACGC ACTTGTAGCC ACGTAGCCAC GCCTACTTAA GACAATTACA AAAGGCGAAG AAGACTGACT CAGGCTTAAG CTGCCAGCCA GAGAGGGAGT CATTrCATrG GCGTTTGAGT CAGCAAAGGT ATTGTCCTCA CATCTCTGGC TATrAAAGTA TCTGTTG TTGMTTCT CTTGGCTGT TTCTCTCAC ATTGCCTTCT CTAAAGCTAC AGTCTCTCCT TTITrCICTT GTCCCTCCCT GGTGGTAT GTGACCTAGA ATTACAGTCA GATTTCAGAA AATGATTCTC TCATITTGCT GATAAGGACT GATTCGTTTT ACTGAGGGAC GGCAGAACTA GTTTCCTATG AGGGCATGGG TGAATACAAC TGAGGCTTCT CATGGGAGGG AATCTCTACT ATCCAAAATT ATTAGGAGAA AATrGAAAAT TTCCAACTCT GTCTCTCTCT TACCTCTGTG TAAGGCAAAT ACCTTATrCT TGTGGTGTTr TTGTAACCTC TTCAAACTTT CATrGATrGA ATGCCTGTTC TGGCAATACA TTAGGTTGGG CACATAAGGA ATACCAACAT AAATAAAACA TTCTAAAAGA AGTTTACGAT CTAATAAAGG AGACAGGTAC ATAGCAAACT AATTCAAAGG AGCTAGAAGA TGGAGAAAAT GCTGAATGTG GACTAAGTCA TTCAACAAAG T1TTCAGGAA GCACAAAGAG GAGGGGCTCC CCTCACAGAT ATCTGGATTA GAGGCTGGCT GAGCTGATGG TGGCTGGTGT TCTCTGTTGC AGAAGTCAAG ATGGCCAAAG TTCCAGACAT GTTTGAAGAC CTGAAGAACT GTFACAGGTA AGGAATAAGA TTTATCTCTT GTGATTTAAT GAGGGTTTCA AGGCTCACCA GAATCCAGCT AGGCATAACA GTGGCCAGCA TGGGGGCAGG CCGGCAGAGG TTGTAGAGAT GTGTACTAGT CCTGAAGTCA GAGCAGGTTC AGAGAAGACC CAGAAAAACT AAGCATrCAG CATGTTAAAC TGAGATTACA TrGGCAGGGA GACCGCCATr TTAGAAAAAT TATTTGAG GTCTGCTGAG CCCTACATGA ATATCAGCAT CAACTTAGAC ACAGCCTCTG TTGAGATCAC ATGCCCTGAT ATAAGAATGG GTITTACTGG TCCATTCTCA GGAAAACTTG ATCTCATTCA GGAACAGGAA ATGGCTCCAC AGCAAGCTGG GCATGTGAAC TCACATATGC AGGCAAATCT CACTCAGATG TAGAAGAAAG GTAAATGAAC ACAAAGATAA AATTACGGAA CATATTAAAC TAACATGATG TTTCCATTAT CTGTAGTAAA TACTAACACA AACTAGGCTG TCAAAATITT GCCTGGATAT TTTACTAAGT ATAAATTATG AAATCTGTI1T TAGTGAATAC ATGAAAGTAA TGTGTAACAT ATAATCTATT TGGTTAAAAT AAAAAGGAAG TGCTTCAAAA CCTTTIT1 CTCTAAAGGA GCTTAACATT CTTCCCTGAA CTrCAATrAA AGCTCTTrCAA IT17GTrAGCC AAGTCCAATT TTACAGATA AAGCACAGGT AAAGCTCAAA GCCTGTCTTG ATGACTACTA ATTCCAGATr AGTAAGATAT GAATTACTCT ACCTATGTGT ATGTGTAGAA GTCCTTAAAT TTCAAAGATG ACAGTAATGG CCATGTGTAT GTGTGTGACC CACAACTATC ATGGTCATTA AAGTACATTG GCCAGAGACC ACATGAAATA ACAACAATTA CATTCTCATC ATCTTAIT[ GACAGTGAAA ATGAAGAAGA CAGTTCCTCC ATTGATCATC TGTCTCTGAA TCAGGTAAGC AAATGACTGT AATTCTCATG GGACTGCTAT TCTTACACAG TGGTCrrC ATCCAAAGAG AACAGCAATG ACTTGAATCT TAAATACTTT TGTITTACCC TCACTAGAGA TCCAGAGACC TGTCTCAT TATAAGTGAG ACCAGCTGCC TCTCTAAACT AATAGTrGAT GTGCATTGGC TTCTCCCAGA ACAGAGCAGA ACTATCCCAA ATCCCTGAGA ACTGGAGTCT CCTGGGGCAG GCTTCATCAG GATGTTAGTT ATGCCATCCT GAGAAAGCCC CGCAGGCCGC T7CACCAGGT GTCTGTCTCC TAACGTGATG TGTTGTGGTT GTCTTCTCTG ACACCAGCAT CAGAGGTTAG AGAAAGTCTC CAAACATGAA GCTGAGAGAG AGGAAGCAAG CCAGCTGAAA GTGAGAAGTC TACAGCCACT CATCAATCTG TGTTATTGTG TTGGAGACC ACAAATAGAC ACTATAAGTA CTGCCTAGTA TGTCTTCAGT ACTGGCTTTA AAAGCTGTCC CCAAAGGAGT ATITCTAAAA TATITTGAGC ATTGTTAAGC AGAITITIAA CCTCCTGAGA GGGAACTAAT TGGAAAGCTA CCACTCACTA CAATCATTGT TAACCTA Ir AGTTACAACA TCTCATIT GAGCATGCAA ATAAATGAAA AAGTCTTCCT AAAAAAATCA TC11111ATC CTGGAAGGAG GAAGGAAGGT GAGACAAAAG GGAGAGAGGG AGGGAAGCCT AATGAAACAC CAGTTACCTA AGACCAGAAT GGAGATCCTC CTCACTACCT CTGTTGAATA CAGCACCTAC TGAAAGAACT TTCATTCCCT GACCATGAAC AGCCTCTCAG CTTCTGTTT CCTTCCTCAC AGAAATCCTT CTATCATGTA AGCTATGGCC CACTCCATGA AGGCTGCATG GATCAATCTG TGTCTCTGAG TATCTCTGAA ACCTCTAAAA CATCCAAGCT TACCTTCAAG GAGAGCATGG TGGTAGTAGC AACCAACGGG AAGGTTCTGA AGAAGAGACG GTTGAGTTTA AGCCAATCCA TCACTGATGA TGACCTGGAG GCCATCGCCA ATGACTCAGA GGAAGGTAAG GGGTCAAGCA CAATAATATC TCTITTAC AGTTAAGC AAGTAGGGAC AGTAGAATIT AGGGGAAAAT TAAACGTGGA GTCAGAATAA CAAGAAGACA ACCAAGCATT AGTCTGGTAA CTATACAGAG GAAAATTAAT TITTATCCT CTCCAGGAGG GAGAAATGAG CAGTGGCCTG AATCGAGAAT ACTTGCTCAC AGCCATTATT TCTTAGCCAT ATTGTAAAGG TCGTGTGACT TTTAGCCTT CAGGAGAAAG CAGTAATAAG ACCACTTACG AGCTATGTTC CTCTCATACT AACTATGCCT CCTrGGTCAT GTTACATAAT CTITCGTGA TTCAGTTCC TCTACTGTAA AATGGAGATA ATCAGAATCC CCCACTCATr GGATTGTTGT AAAGATTAAG AGTCTCAGGC TTTACAGACT GAGCTAGCTG GGCCCTCCTG ACTGTTATAA AGATTAAATG AGTCAACATC CCCTAACTTC TGGACTAGAA TAATGTCTGG TACAAAGTAA GCACCCAATA AATGTTAGCT ATTACTATCA TTATTATTAT TATITTATTT ITITITTrG AGATGGAGTC TGGCTCTGTC ACCCAGGCTG GAGTGCAGTG GCACAATCTC GGCTCACTGC AAGCTCTGCC TCCTGGGTTC ATGCCATrCT CCTGCCTCAG CCTCCCGAGT AAGCTGGGAA TACAGGCACC CGCCACTGTT CCCGGCTAAT 11T1GTATT TTAGTAGAG ACGGAGTTC ACCGTGGTCT CCATCTCCTC GTGATCCACC CACCTTGGCC TCCCAAAGTG CCGGGATTAC AGGCGTGAGC CACCGCGCCC GGCCTATTAT TATTATTATT ACTACTACTA CTACCTATAT GAATACTACC AGCAATACTA ATATAAT GACTGGATTA TGTCTAAACC TCACAAGAAT CCTACCTTCT CATITTACAT AAAAGGAAAC TAAGCTCATT GAGATAGGTA AACTGCCCAA TGGCATACAT CTGTAAGTGG GAGAGCCTCA AATCTAATTC AGTCTACCT GAGTAAAAAA ATCATGGTTT CTCCTCCATC CCT'ACTGT ACAAGCCTCC ACATGAACTA TAAACCCAAT ATTCCTGTTT TTAAGATAAT ACCTAAGCAA TAACGCATGT TCACCTAGAA GGTITTAAAA TGTAACAAAA TATAAGAAAA TAAAAATCAC TCATATCGTC AGTGAGAGTT TACTACTGCC AGCACTATGG TATGTTCCT TAAAATCT GCTATACACA TACCTACATG TGAACAAATA TGTCTAACAT CAAGACCACA CTA'TACAA CTTATATCC AGC1111CTr ACTTAGCAAT GTATTGAGGA CATTAGAG TGCCCGTT TCACCATTAT AAGCAATGCA ACAATGAACA TCTGTATAAA TAAATATTCA TTTCTCTCAC CCTTATTTC CTTAGAATAT ATTCCTAGAA GTAGAATTC CCAGAGCCAT GAGGATGT GACGCTATTG ATATGTGCCA CTTGCACTC TCTGTGACAT ATATAATTAT TTTAATGCA TTCATTIT11 TCTCAGAGTG CATTCGT'TG AAAACATAGA CGGGAAATAC TGGTAGTCTT CCTTGTCAGT TAGAAACACC CAAACAATGA AAAATGAAAA AGTTGCACAA ATAGTCTCTA AAAACAATGA AACTATTGCC TGAGGAATTG AAGTTTAAAA AGAAGCACAT AAGCAACAAC AAGGATAATC CTAGAAAACC AGTTCTGCTG ACTGGGTGAT TTCACTTCTC TGCTTCCT CATCTGGATT GGAATATTCC TAATACCCCC TCCAGAACTA TTTCCCTGT TTGTACTAGA CTGTGTATAT CATCTGTGTT TGTACATAGA CATTAATCTG CACTTGTGAT CATGGTTTTA GAAATCATCA AGCCTAGGTC ATCACCT AGCITTCCTGA GCAATGTGAA ATACAAC=T ATGAGGATCA TCAAATACGA ATTCATCCTG AATGACGCCC TCAATCAAAG TATAATTCGA GCCAATGATC AGTACCTCAC GGCTGCTGCA TTACATAATC TGGATGAAGC AGGTACATTA AAATGGCACC AGACATTCT GTCATCCTCC CCTCCITTCA TTACTTrATT TAITA'TTTC AATCTTCTG CTTGCAAAAA ACATACCTCT TCAGAGTTCT GGGTTGCACA ATTCTrCCAG AATAGCTTGA AGCACAGCAC CCCCATAAAA ATCCCAAGCC AGGGCAGAAG GTTCAACTAA ATCTGGAAGT TCCACAAGAG AGAAGTTCC TATCIT=GAG AGTAAAGGGT TGTGCACAAA GCTAGCTGAT GTACTACCTC TTGGTTCTT WO 00/09525 PCT/US99/1 77-12 EPI-109 193 TCAGACATTC T7ACCCTCAA 'FTrAAAACT GAGGAAACTG TCAGACATAT TAAATGAn7T ACTCAGATI1 ACCCAGAAGC CAATGAAGAA CAATCACTC~T CC'TAAAAA GTCTGTrGAT CAAACTCACA AGTAACACCA AACCAGGAAG ATC'ITA TCTCTGATAA CATA'r=GTG AGGCAAAACC TCCAATAAGC TACAAATATG GC=AAAGGA TGAAGTI1AG TGTCCAAAAA CITIATCAC ACACATCCAA T=FCATGGC GGACATGTrT TAG'ITrCAAC AGTATACATA TITCAAAGG TCCAGAGAGG CAA'1rGCA ATAAACAAGC AAGACIT'T CTrGAUGGAT GCACTI'CAGC TAACATGCrT TCAACTCTAC ATIACAAAT TATITGTGT TCTATIT=C TAc=AATAT TAMTGCA ATTICCCAA TATrGACATC GTGTATGTAT TTGCCAT1T TAATATCACT AGACAAflCA ATCAGGTrGC TACGTrGGTC CcrGGGTIIr ACTCTAAATA G=FGATTGC AAATATCI= GTATATAT7A rrGITITFC TCCrATCTG TAA ITC1T GAGCACATCC CAAAGAGGAA TGCCTAGATC AATGGGCACA AATAAn7~GA CAGCTCT7AT TAAACATTAT TCTGTAAGTA AAAACTrGAAC TACTX=CAG TATCACTAGC AACATATGAG TGTATCAGCT TCCTAAACCC CTCCATGTTA GGTCATrATG AACTATGAT CTAACAAA Fr ACAGGGTCTF ATCCCACTAA TGAAATTATA AGAGA17CAA CACTTATTCA GCCCCGAAGG A~rrCATrCAA CGTAGAAAAT TCTAAGAACA TTAACCAAGT A7TJ7ACCTGC CrAGTGAGTG TGGAAGACAT TGTGAAGGAC ACAAAGATGT ATAGAATrCC AITCCTGACT TCCAGGTATT TACACCATAG GTGGGGACCT AACTACACAC ACACACACAC ACACACACAC ACACACACAC ACCATGCACA CACAATCTAC ATCAACAC'Fr GATITATAC AAATACAATG AA=IA=FI CTITIGGT7 =~CTCTTCA CCAGTGAAAT TTGACATGGG TGC11ATAAG TCATCAAAGG ATGATGCTAA AATFACCGTG AT-rC7AAGAA TCTCAAAAAC TCAAT7GTAT GTGACTGCCC AAGATGAAGA CCAACCAGTG CTGCTGAAGG TCAGTrGTCC MrGTCTCCA A=TACCTTC A=IACATCT CATATG'TrTG TAAATAAGCC CAATAGGCAG ACACCTCTAA CAAGGTGACA CTGTCCTCT TCCTCCTAC CACAGCCCCC ACCTACCCAC CCCACTCCCA TTGATTCCAG AGGCGTGCCT AGGCAGGATC TATGAGAAAA TATAACAGAG AGTAAGAGGA AAAT7ACCTF7 Cr'T CC'=CCCTrG CCTGACCTTA TTCACCTCCC ATCCCAGAGC ATCCA'ITAT TCCAT7GATC TITACTGACA TCTAT7ATCT GACCTACACA ATACTAGACA TJ7AGGACAAT GTGCICCTGCC TCCAAGAAAC TCAAATAAGC CAACTGAGAT CAGAGAGGAT TAATCACCTG CCAATGGGCA CAAAGCAACA AGCTGGGAGC CAAGTCCCAA AATGGGGCCT GCTGCICCA G'FFCCCCTCT CTCrGCATTG ATGTCAGCAT TATCCTrCGT CCCAGTCCTG TCTCCACTAC CA=IJCCCC CTCAAACACA CACACACACA ACAGCCTAG ATGTITCTC CACTGATAAG TAGGTGA~rC AA'ITGTAAG TATATAATCC AAGACCTCT ATTCCCAAGT AGAATITATG TGCCTGCCTG TGCTI=CTA CCTGGATCAA GTGATGT~rA CAGAGTAGGG CAGTAGCC ATCATGAAC TCATTCAACA AGCATrATrC ACTGAGAGCC TTGTA CAGGCATAGT GCCAACAGCA GTGTGGACAG TGGTGCATCA AAGCCTCrAG TCTCATAGAA CTAGTCTC TGGAGGATAT GGAAAACAGA CAACCCAAAC AACCAACAAA AGAGCAAGAT GCTGCAAAAA AAAAAAAAAT GAATAGGGTG CTAAGATAGA GAAAAGTGGG AGAGTGCTAT TTAGACAAAG TGGTAAAAAC AAAGCCCCTr GTGAGATGAG AGCTGCCGAC AGAGGGGGCG GGTCATGGT'T GTGGG'ITIT GGGTAGGACA FrCAGAGGAG GGGGCGGGTC GTGGTTGTGG GrrITGGGT AGGACAT7CA GAGGAGGGGG CGGGTCGTGG TTGTGGG=1 TI7GGGTAGGA CA ITCAGAGG AGGGGGCGGG TCGTGGT7GT GGG TIT=GG GTAGGACA'rr CAGAGGAGGG GGCGGGTCGT GGTI'GTGGGT TIGGGACA TTCAGAGGAG TCTGAATGCA CCCAGGCCTA CAACTrCAAG ATGGTAAAGG ACAGCTCCAA GGATCAGAAG AAGCATrCT GGAACTGGGG CATITGAGA AGGAGGAAAA ATATGCAGAG ACTAGTG=T GCAGAGCTrG CATTTGGATr TCKITT1GAGG TACAATGAAA ACCCATTAAT GGG'TrCACA CAGTGCAATG GCCTGACCTC AC11ATA'I= CCTAAAATAG AAAACAGATC AGAAGGAAGG CAATAGAGAA GCAGAAAGTC CAATGAGGAG GTTCACAGC AGTCATGGGG GTGGGGTAAG GAAAAGAAGT GGAAAGAAAC AGACAGAATT GGG FTATAT7 T7GGAGATAG AACCAACAGA AGGAAGAGGA GAAACAACAT T-fACTGAGAA GGGAAAAAGT AGGAGAGGAA TAGG'FITGGG AAATAAATCC TGCTGACAT7 GGAAACCCCA AGGAAGCCrC AAAAGTATAT TTACTTGCT TAGK111TAAA AGAATAGGAA AGAAGCATCT CAACT]GGAA 'TTrGAAATCT ATflTCCAT AAAAGTATTG TTAAATTCTA CTCATACTCA CAAGAAAAGT ACATIXTAAA GAGTATATFG AAAGAGTITA CTGATATACT TAGGAXITI GTGTGTATGT GTGTGTGTGT ATGTGTGTGT GTGTGTIAA CCTTCAATTG TrGA=IAAA TACTGAGATA AATGTCATCT AAATGCTAAA TTGA1TCCC AAAGGTATGA MTGTrCACT TGGAGATCAA AATG FMAGG GGGC=AGAA TCAGTGTAGT GCTCAGAI7r GATGCAAAAT GT=~AGGCC TATGT7GAAG GCAGGACAGA AACAATGTI CCCTCCTACC TGCCTGGATA CAGTAAGATA CTAGTGTCAC TGACAATCT7 CATAACTAAT I1TAGATCrCT CTCCAATCAA CTAAGGAAAT CAACTCTTAT TAATAGACTG GGCCACACAT CTACTAGGCA TGTAATAAAT GCTrGCTGAA TGAACAAATG AATGAAGAGC CTATAGCATC ATGT7ACAGC CATAGTCCTA AAGTGGTGT7 TCTCATGAAG GCCAAATGCr AAGGGA'FFGA GC1CAGTCC ITITCTAAC ATCTGTTCT CTAACAGAAT TCTCT=1T T=TCATAGG AGATGCCTGA GATACCCAAA ACCATCACAG GTAGTGAGAC CAACCTCCTC T=CTGGG AAACTCACGG CACTAAGAAC TATTICACAT CAGT-TGCCCA TCCAAAQTG 'I=ATrGCCA CAAAGCAAGA CTACrGGGTG TGCTTGGCAG GGGGGCCACC CrCTATCACT GAC=rCAGA TACTGGAAAA CCAGGCGTAG GTCTGGAGTC TCACTTGTCT CACTTGTGCA GTGTrGACAG 7rCATATGTA CCATGTACAT GAAGAAGCTA AATCC'ITrAC TGTrAGTCAT TlGCTGAGCA TGTACTGAGC CTTGTAATTC TAAATGAATG n7IACACTCr TTGTAAGAGT GGAACCAACA CTAACATATA ATGTrGT7AT TTAAAGAACA CCCTATAIT TGCATAGTAC CAATCATTT AAT7ATrAT7 =~CATAACA A=FTAGGAG GACCAGAGCT ACTGACTATG GCTACCAAAA AGACTCTACC CATATTACAG ATGGGCAAAT TAAGGCATAA GAAAACTAAG AAATATGCAC AATAGCAGl GAAACAAGAA GCCACAGACC TAGGA'T7CA TGAM~CAT7 TCAACTGInr GCCTCTGCT MIAAGTrGC TGATGAACTC TTAATCAAAT AGCATAAGTT TCrGGGACUr CAG=1IATC A=IICAAAA TGGAGGGAAT AATACCTAAG C=TCCTGCC GCAACAGTI =~ATGCTFAA TCAGGGAGGT CA=flGGTA AAATACrrCT CGAAGCCGAG CCTCAAGATG AAGGCAAAGC ACGAAATGfl ATrAAT TATTAM~AT ATATGTA=h ATAAATATAT TrAAGATAAT TATAATATAC TATAMTATG GGAACCCCFr CATCCTCTGA GTGTGACCAG GCATCCTrCCA CAATAGCAGA CAGTGT1TC TGGGATAAGT AAG'I7rGATr TCAT]7AATAC AGGGCATI= GGTCCAAGFIT GTGCTTATCC CATAGCCAGG AAACTCTGCA TTCTAGTACT TGGGAGACCT GTAATCATAT AATAAATGTA CATTAATrAC CTGAGCCAG TAATrGGTCC GATC'IMGAC TC~rTGCCA T7AAAC1TAC CTGGGCATrC TrGMrCATr CAATrCCACC TGCAATCAAG TCCTACAAGC TAAAATTAGA TGAACTCAAC 'IMGACAACC ATGAGACCAC TGTrATCAAA A=C'Ir F CTGGAATGTA ATCAATGTI CTTCTAGGTF CTAAAAATI'G TGATCAGACC ATAATGTrAC AYrATrATCA ACAATAGTGA TrGATAGAGT GTTATCAGTC ATAACTAAAT AAAGCTrGCA ACAAAATflCT CTGACACATA GT7ATrCA'r GC=TAATCA TrATITACT GCATGGTAAT TAGGGACAAA TGGTAAATGT TrACATAAAT AATrGTA=~ AGTGT7ACTT TATAAAATCA AACCAAGAT7 TTATA II= T7CTCCTC~r TGTTAGCTGC CAGTATGCAT AAATGGCAI7 AAGAATGATA ATA'I7rCCGG G FrCACT7AA AGCTCATA IT ACACATACAC AAAACATGTG T7CCCATCT TATACAAACT CACACATACA GAGCTACAIT AAAAACAACTr AATAGGCCAG GCACGGTGGC TCAGACCTGT AATCCCAGCA C1TGGGAGG- 3' (FRAG. NO: _) (SEQ. ID NO:2510) 5'-ACCAACCTrCT TCGAGGCACA AGGCACAACA GGCTGCTCTG GGATTCTCTf CAGCCAATCT TCATI'GCTCA AGTGTCTGAA GCAGCCATGG CAGAAGTACC TGAGCTCGCC AGTGAAATGA TGG=TT1A CAGTGGCAAT GAGGATGACT TGTTC=~GA WO 00/09525 PCT/US99/1 7712 EPI-1 09 194 AGCTGATGGC CCTAAACAGA TGAAGTGCTC CTITCCAGGAC CTGGACCTCT GCCCTCTGGA TGGCGGCATC CAGCTACGAA TCTCCGACCA CCACTACAGC AAGGGCTTCA GGCAGGCCGC GTCAGTTGTT GTGGCCATGG ACAAGCTGAG GAAGATGCTG GTrCCCTGCC CACAGACCTT CCAGGAGAAT GACCTGAGCA CC~rC1TCC CTTCATCT= GAAGAAGAAC CTATCTT= CGACACATGG GATAACGAGG C17ATGTGCA CGATGCACCT GTACGATCAC TGAACTGCAC GCTCCGGGAC TCACAGCAAA AAAGCrTGGT GATGTCTGGT CCATATGAAC TGAAAGCTCT CCACCTCCAG GGACAGGATA TGGAGCAACA AGTGGTG'ITC TCCATGTCCT T7GTACAAGG AGAAGAAAGT AATGACAAAA TACCTGTGGC CIGGGCCTC AAGGAAAAGA ATCTrGTACCT GTCCTGCGTG T-rGAAAGATG ATAAGCCCAC TCTACAGCTG GAGAGTGTAG ATCCCAAAAA 'FrACCCAAAG AAGAAGATGG AAAAGCGATr TGTCT-rCAAC AAGATAGAAA TCAATAACAA GCrGGAAMF GAGTCTGCCC AGUTCCCCAA CTGGTACATC AGCACCTCTC AAGCAGAAAA CATGCCCcITC T7CC7GGGAG GGACCAAAGG CGGCCAGGAT ATAACTGACT TCACCATGCA A'IMGTGTCT TCCTAAAGAG AGCTGTACCC AGAGAGTCCT GTGCTGAATG TGGACTCAAT CCCTAGGGCT GGCAGAAAGG GAACAGAAAG G~TTGAGT ACGGCTATAG CCTGGACT= CCTGTTGTCT ACACCAATGC CCAACTGCCT GCCTrAGGGT AGTGCTAAGA GGATCTCCTG TCCATCAGCC AGGACAGTCA GCTCTCTCCT TTCAGGGCCA ATCCCCAGCC C=rrGTrGA GCCAG3GCCTC TCrCACCTCT CCrACTCACT TAAAGCCCGC CrGACAGAAA CCACGGCCAC AT17GGTrCT AAGAAACCCT CTGTCAT'rCG CTCCCACAT7 CTGATGAGCA ACCG=~CCC TATTTA MIA'ITGTT TGMIG'TrT ATTCA rFGGT CTAA ITAT7 CAAAGGGGGC AAGAAGTAGC AGTGTCTGTA AAAGAGCCTA GT=ITAATA GCTATGGAAT CAATrCAATT TGGACTGGTG TGCTCTCT= AAATCAAGTC CT=AATTAA GACTGAAAAT ATATAAGCTC AGATTAMTA AATGGGAATA 'IMATAAATG AGCAAATATC ATACTGTTCA ATGG~rCrGA AATAAACITC TCTGAAG-3' (FRAG. NO:_)(SEQ. ID NO:2511) 5'-AGAAAGAAAG AGAGAGAGAA AGAAAAGAAA GAGGAAGGAA GGAAGGAAGG AAGAAAGACA GGCTCTGAGG AAGGTGGCAG TTCCTACAAC GGGAGAACCA GTGGTrAATT TGCAAAGTGG ATCCTGTGGA GGCANNCAGA GGAGTCCCCT AGGCCACCCA GACAGGGCTr TrAGCTATCr GCAGGCCAGA CACCAAA IT CAGGAGGGCT CAGTGTrAGG AATGGATTAT GGCT7ATCAA ATI7CACAGGA AACTAACATG F7GAACAGCT 71TAGATITC CTGTGGAAAA TATAACTrAC TAAAGATGGA GUTCTFTGTGA CTGACTCCTG ATATCAAGAT AC-TGGGAGCC AAA'ITAAAAA TCAGAAGGCT GCTrGGAGAG CAAGTCCATG AAATGcCT= TT7CCCACAG TAGAACCTAT 'FrCCCTCGTG TCTCAAATAC TTGCACAGAG GCTCACTCCC T7GGATAATG CAGAGCGAGC ACGATACCTG GCACATACTA A'ITGAATAA AATGCTGTCA AATrCCCAT7 CACCCATrCA AGCAGCAAAC TCTATCTCAC CTGAATGTAC ATGCCAGGCA CTGTGCTAGA CTTGGCTCAA AAAGATTI7CA GTnTCCTGGA GGAACCAGGA GGGCAAGG Fr TCAACTCAGT GCTATAAGAA GTGTTACAGG CTGGACACGG TGGCTCACGC CTGTAATCCC AACATIT7GGG AGGCCGAGGC GGGCAGATCA CAAGGTCAGG AGATCGAGAC CATCCTGGCT AACATGGTGA AACCCTGTCT CTACTAAAAA TACAAAAAAT TAGCCGGGCG TTGGCGGCAG GTGCCTrGTAG TCCCAGC7GC TGGGGAGGC7 GAGGCAGGAG AATGGTGTGA ACCCGGGAGG CGGAACTTGC AGGGGGCCGA GATCGTGCCA CTGCACTCCA GCCTGGGCGA CAGAGTGAGA CrCrGTCTCA AAAAAAAAAA AAAAGTGTTA TGATGCAGAC CTGTCAAAGA GGCAAAGGAG GGTGTrCCTA CACTCCAGGC ACTGTTCATA ACCTGGACTrC TCA F7CATTC TACAAATGGA GGGCTCCCCT GGGCAGATCC CTGGAGCAGG CACITIGCTG GTGTCTCGGT TAAAGAGAAA CTGATAACTC TFIGGTATTAC CAAGAGATAG AGTCTCAGAT GGATATrc'r ACAGAAACAA TATTCCCACT TTCAGAGTr CACCAAAAAA TCA'ITIAGG CAGAGCTCAT CTGGCA'ITGA TCrGGTTCAT CCATGAGATT GGCTAGGGTA ACAGCACCTG GT=~GCAGG GTrGTGTGAG CTrATCTCCA GGGTTGCCCC AACTCCGTCA GGAGCCTGAA CCCTGCATAC CGTATGTTCT CTGCCCCAGC CAAGAAAGGT CAA=I~CTC CTCAGAGGCT CCTGCAAT7G ACAGAGAGCT CCCGAGGCAG AGAACAGCAC CCAAGGTAGA GACCCACACC CTCAATACAG ACAGGGAGGG CTA'I1GGCCC TrCATrGTAC CCA'IMATCC ATCTGTAAGT GGGAAGA7rC CTAAACTrAA GTACAAAGAA GTGAATGAAG AAAAGTATGT GCATGTATAA ATCI'GTGTGT C'rTCCAC= GTCCCACATA TACTAAA'IT AAACATrC= CTAACGTGGG AAAATCCAGT ATITAATGT GGACATCAAC TGCACAACGA TrGTCAGGAA AACAATGCAT A1GCATGG TGATACAM~ GCAAAATGTG TCATAGTTG CTACTCCTTG CCCT'rCCATG AACCAGAGAA 'rrATCTCAGT TFTAflAGTCC CCTCCCCTAA GAAGCTrCCA CCAATACTCr n7~CCCC=r C=T~AACTTr GATTGTGAAA TCAGGTATTC AACAGAGAAA 7I7CCTCAGCC TCCTACTTCT GCTITGAAA GCTATAAAAA CAGCGAGGGA GAAACTGGCA GATACCAAAC CTCTCGAGG CACAAGGCAC AACAGGCTGC TCTGGGATFC TCT-rCAGCCA ATCITCAITrG CTCAAGTATG AC1TAATCT TCCTACAAC TAGGTGCTAA GGGAGTCTCT CTGTCTCTCT GCcTCITGT GTGTATGCAT ATTCrCTCTC TCTCTCTC'Fr TCTTTCTCTG TCTCTCCTCT CCTCCTCTC TGCCTCCTCT CTCAGCTIT TGCAAAAATG CCAGGTGTAA TATAATGCTT ATGACTCGGG AAATATrCTG GGAATGGATA CTGCTrTATCT AACAGCTGAC ACCCTAAAGG TTAGTGTCAA AGCCTCTGCT CCAGCTCTCC TAGCCAATAC A~rGCTAG Fr GGGG'ITrGGT F7AGCAAATG CrTMCTCTA GACCCAAAGG AcCICTI CACACATTCA T7CAnf7ACT CAGAGATCAT TTCFTGCAT GACTFGCCATG CACTGGATGC TGAGAGAAAT CACACATGAA CGTAGCCGTC ATGGGGAAGT CACTCAT1T CTCCTTITA CACAGGTGTC TGAAGCAGCC ATGGCAGAAG TACCTrGAGCT CGCCAGTGAA ATGATGGCTr ATrACAGGTC AGTGGAGACG CTGAGACCAG TAACATGAGC AGGTCTCCTC TTCAAGAGT AGAGTGTTAT CTGTGCTrGG AGACCAGATT MTCCCCTAA ATTGCCTCTr TCAGTGGCAA ACAGGGTGCC AAGTAAATCT GATT7AAAGA CTACITCCC ATrACAAGTC CCTCCAGCCT TGGGACCTGG AGGCTATCCA GATGTG TGT TGCAAGGGCT TCCTGCAGAG GCAAATGGGG AGAAAAGATT CCAAGCCCAC AATACAAGGA ATCCCT7GC AAAGTGTGGC T7GGAGGGAG AGGGAGAGCT CAGATITAG CTGACrCTGC TGGGCTAGAG GTTAGGCCTC AAGATCCAAC AGGGAGCACC AGGGTGCCCA CCTGCCAGGC CTAGAATCTG C=FCTGGAC TG~rCTGCGC ATATCACTGT GAAACTTGCC AGGTGTI7rCA GGCAGCTIG AGAGGCAGGC TGTITGCAGT 'TCT7ATGAA CAGTCAAGTC TrGTACACAG GGAAGGAAAA ATAAACCTGT 7FAGAAGACA TAAT7GAGAC ATGTCCCTGT =TrFACA GTGGCAATGA GGATGACITG Tr'T=GAAG CTGATGGCCC TAAACAGATG AAGGTAAGAC TATGGGTI17A ACTCCCAACC CAAGGAAGGG CTCTAACACA GGGAAAGCTC AAAGAAGGGA G17CTGGGCC ACTFGATGC CATGGTA=T TG=F~AGAA AGAC1TAAC CTCT-rCCAGT GAGACACAGG CTGCACCACT TGCTGACCTG GCCACTrGGT CATCATATCA CCACAGTCAC TCACTAACGT TGGTGGTGGT GGCCACAC= GGTGGTGACA GGGGAGGAGT AGTGATAATG TTCCCA'ITrC ATAGTAGGAA GACAACCAAG TCT-rCAACAT AAATFTGATT ATCCTI=AA GAGATGGATI' CAGCCTATGC CAATCACrrG AG~rAAACTC TGAAACCAAG AGATGATC11T GAGAACTAAC ATATGTCTAC CCCTITGAG TAGAATAG11 TITGCTACC TGGGGTGAAG CIATAACAA CAAGACATAG ATGATATAAA CAAAAAGATG AATrGAGACT TGAAAGAAAA CCATTCACrr GCrGTGAC CTTGACAAGT CAT1TACCC GCTIGGACC TCATCTGAAA AATAAAGGGC TGAGCTGGAT GATCTCTGAG AT7CCAGCAT CCTGCAACCT CCAGTTCTGA AATA'1ICA GT7GTAGCTA AGGGCAMrG GGCAGCAAAT GGTCA TIT CAGACTCATC C17ACAAAGA GCCATGTAT ATTCCTGCrG TCCCI1CTGT TnTATATGAT GCTCAGTAGC CITCCTAGGT GCCCAGCCAT CAGCCTAGCT AGGTCAGTTG TGCAGGT7GG AGGCAGCCAC TITCTCTGG CTPATrA TTCCAGT17G TGATAGCCTC CCCTAGCCTC ATAATCCAGT CCTCAATC= GTFTAAAAACA TKITFCITA GAAGT=~AA GACTGGCATA AC=CTGGC TGCAGCTGTG GGAGGAGCCC AT7GGCTGT CTGCCTGGCC 'FIGCCCCCC A'ITGCCTCT7I CCAGCAG3CT7 GGCTCTGCTC CAGGCAGGAA ArCrCTCCT WO 00/09525 PCTIUS99/1 7712 EPI-109 195 GCTCAACIT CTI=GTGCA CTrACAGGTC TCITAACTG TC1TCAAGC CI=GAACCA TrATCAGCCTr TAAGGCAACC TCAGTGAAGC CTTAATACGG AGCrCCTG AATAAGAGGA AAGTGGTAAC A TrCACAAA AAGTACTOTC ACAGG3AT7G CAGAATGCCT ATGAGACAGT GTTATGAAAA AGGAAAAAAA AGAACAGTGT AGAAAAA'ITG AATACTrGCT GAGTGAGCAT AGGTGAATGG AAAATGTrAT GGTCATCTGC ATGAAAAAGC AAATCATAGT GTGACAGCAT TAGGGATACA AAAAGATATA GAGAAGGTAT ACATGTATGG TGTAGGTGGG GCATGTACAA AAAGATGACA AGTAGAATCG GGMT=ATTC TAAAGAATAG CCTGTAAGGT GTCCAGAAGC CACATrCTAG T=~GAGTCT GCCTCTACCT GCTGTGTGCC CT7GAGTACA CCC'ITAACCT CCTGAGCTT CAGAGAGGGA TAATCITrr7 A=I~A=I A=1TATI G=IIGT=IT G=lrG=Ir GTIATGAG ACAGAGTCTC ACTCTGTTGC CCAGGCTGGA GTGCAGTGGT ACAATCTTGG CT7ACTGCAT CCTCCACCTC CTGAG'ITCAA GCGATTCTCC TTCCTCAGTC TCCTGAATAG CTAGGATTAC AGGTGCACCC CACCACACCC AGCTAAT1T TGTA'TI=A GTAGAGAAGG GGTITCGCCA TGTrGGCCAG GCTGG1T=G AAGTCCTGAC CTAAATGAT7 CATCCACCTC GGCTCCCAA AGTGCTGGGA TrACAGGCAT GAGCCACCAC GCCTrGGCCCA GAGAGGGATG ATCT=AGAA GCTCGGGATT CI=CAAGCC CTICCTCCT CTCTGAGCTI' TCTACTCTCT GATGTCAAAG CATGGTTCCT GGCAGGACCA CCTCACCAGG CrCCCTCCCT CGCTCTCTCC GCAGTGCTCC T7CCAGGACC TGGACCrTG CCCTCTGGAT GGCGGCATCC AGCTACGAAT CTrCCGACCAC CACTACAGCA AGGGCTTCAG GCAGGCCGCG TCAGTrG77G TGGCCATGGA CAAGCTGAGG AAGATGCTGG TTCCCTGCCC ACAGACCTC CAGGAGAATG ACCTGAGCAC clrcrCCC TTCATUI I IG AAGAAGGTAG TrAGCCAAGA GCAGGCAGTA GATCTCCACT TGTGTCCrCT TGGAAGTCAT CAAGCCCCAG CCAACTCAAT TCCCCCAGAG CCAAAGCCCT TAAAGGTAG AAGGCCCAGC GGGGAGACAA AACAAAGAAG GCTGGAAACC AAAGCAATCA TCTr=AGT GGAAACTAT7 M~AAAGAAG ATCTrGATGG CTACTGACAT TTGCAACTCC CrCACT=rr CTCAGGGGCC ITCAC=AC A7TGTCACCA GAGGTTCGTA ACCTCCCTGT GGGCTAGTGT TATGACCATC ACCA=IrAC CTAAGTAGCT CTGT7GCTCG GCCACAGTGA GCAGTAATAG ACCTGAAGCT GGAACCCATG TCTAATAGTG TCAGGTCCAG TGTrCrTAGC CACCCCACTC CCAGCTTCAT CCCTACTGGT GTrGTCATCA GAC=rGACC GTATATGCTC AGGTGTCCTC CAAGAAATCA AATITGCCA CCTCGCCTCA CGAGGCCTGC CCTTCTGA IT T7ATACCTAA ACAACATGTG CTCCACAM~ CAGAACCTAT ==C~CGAC ACATGGGATA ACGAGGCTTA TGTGCACGAT GCACCTGTAC GATCACTGAA CTGCACGCTC CGGGACTCAC AGCAAAAAAG CTGGTGATG TCTGGTCCAT ATGAACTGAA AGCTCTCCAC CTCCAGGGAC AGGATATGGA GCAACAAGGT AAATGGAAAC ATCCTGGT~r CCCTGCCTGG CCTCCTGGCA GC17GCTAAT TCTCCATGT7 TTAAACAAAG TAGAAAGTrA A'ITAAGGCA AATGATCAAC ACAAGTGAAA AAAAATATTA AAAAGGAATA TACAAAUIT GGTCCTAGAA ATGGCACAT7 TGATrGCACT GGCCAGTGCA 'T17G I1AACA GGAGTGTGAC CCTGAGAAAT TAGACGGCTC AAGCACTCCC AGGACCATGT CCACCCAAGT CTCTTGGGCA TAGTGCAGTG TCAATTr'IC CACAATATGG GGTCAITGA TGGACATGGC CTAACTGCCT GTGGG'I1XTC TCTITCCrGUT GTI'GAGGCTG AAACAAGAGT GCTGGAGCGA TAATGTGTCC ATCCCCCTCC CCAGTCTTCC CCCCrTGCCC CAACATCCGT CCCACCCAAT GCCAGGTGGT TCC1TGTAGG GAAATITTAC CGCCCAGCAG GAACITATAT CTCTCCGCTG TAACGGGCAA AAG ITCAAG TGCGGTGAAC CCATCATTAG CTGTGGTGAT CTGCCTGGCA TCGTGCCACA GTAGCCAAAG CCTCTGCACA GGAGTGTGGG CAACTAAGGC TGCTGAC'T GAAGGACAGC CTCACTCAGG GGGAAGCTAT TTG~rCTCAG CCAGGCCAAG AAAATCCTGT TrT=GGAA TCGGGTAGTA AGAGTGATCC CAGGGCCTCC AA'rTGACACT GCTGTGACTG AGGAAGATCA AAATGAGTGT CTCTCTIGG AGCCAC'=C CCAGCTCAGC CTCTCCTCTC CCAG'TrCTT CCCATGGGCT ACTCTCTGTT CCTGAAACAG TrCTGGTGCC TGATI1CTGG CAGAAGTACA GC1TCACCTC rrrCcrrCC TrCCACATTG ATCAAGTTGT TCCGCTCC1'G TGGATGGGCA CATTGCCAGC CAGTGACACA ATGGCTTCCT TCCTTCCTTC CTTCAGCATT TAAAATGTAG ACCCr=T1C ATTCTCCGTr CCTACTGCTA TGAGGCTCTG AGAAACCCTC AGGCc=rGA GGGGAAACCC TAAATCAACA AAATGACCCT GCTATrGTCT GTGAGAAGTC AAGTTATCCT GTGTCT-rAGG CCAAGGAACC TCACTGTGGG T7CCCACAGA GGCTACCAAT TACATGTATC CTACTCTCGG GGCTAGGGGT TGGGGTGACC CTGCATGCTG TGTCCCTAAC CACAAGACCC CCTC7~C TCAGTGGTGT TCTCCATGTC C1TGTACAA GGAGAAGAAA GTAATGACAA AATACCTGTG GCCTGGGCC TCAAGGAAAA GAATCTGTAC CTGTCCTGCG TGYFGAAAGA TGATAAGCCC ACTCTACAGC TGGAGGTAAG TGAATGCTAT GGAATGAAGC C=ICTCAGC CTCCTGCTAC CACTTTCC CAGACAATrC ACCTTCTCCC CGCCCCCATC CCTAGGAAAA GCTGGGAACA GGTCTAM~G ACAAGTITG CATrAATGTA AATAAATITA ACATAA=Ir TAACTGCGTG CAACCTTCAA TCCTGCTGCA GAAAATTAAA TCATITGCC GATGTI2ATTA TGTCCTACCA TAGflACAAC CCCAACAGAT TATATATTGT TAGGGCrGCT CTCA'ITGAT AGACACCT-rG GGAAATAGAT GACTTAAAGG GTCCCATTAT CACGTCCACT CCACTCCCAA AATCACCACC ACTATCACCT CCAGCFC CAGCAAAAGC TrCA TTCCA AGTrGATGTC ATTCTAGGAC CATAAGGAAA AATACAATAA AAAGCCCCTG GAAACTAGGT ACTTCAAGAA GCTCTAGCrT AAI=rCACC CCCCCAAAAA AAAAAAAT]TC TCACCTACAT TATGCTCCTC AGCAM~GGC ACTAAG=rr AGAAAAGAAG AAGGGCTC17T UAATAATCA CACAGAAAGT TGGGGGCCCA GTTACAACTC AGGAGTCTGG CTCCTGATCA TGTGACCTGC TCGTCAGTIT CCrCGGC CAACCCAAAG AACATC CCATAGGCAT ='TGTCCCT TGCCCCACAA AAAT7CTrCT FrCrCICG CTGCAGAGTG TAGATCCCAA AAATrACCCA AAGAAGAAGA TGGAAAAGCG AITTGT=~C AACAAGATAG AAATCAATAA CAAGCTGGAA 'ITGAGTCTG CCCAG77CCC CAACTGGTAC ATCAGCACCT CTCAAGCAGA AAACATGCCC GTCT7CCrGG GAGGGACCAA AGGCGGCCAG GATATAACTG ACTTCACCAT GCAATTGTG T='1CCTAAA GAGAGCTGTA CCCAGAGAGT CCTrGTGCTGA ATGTGGACTC AATCCCTAGG GCTGGCAGAA AGGGAACAGA AAGGT=rG AGTACGGCTA TAGCCTGGAC TITCCTGT7G TCTACACCAA TGCCCAACTG CCTGCC'AG GGTAGTGCTA AGAGGATCTC CTGTCCATCA GCCAGGACAG TCAGCTCTCT CCTICAGGG CCAATCCCCA GCCCTITGT TGAGCCAGGC CTCTCTCACC TCTCCTACrC ACTTAAAGCC CGCCTGACAG AAACCACGGC CACAITTrGGT TCTAAGAAAC CCTCTGTCAT TCGCTCCCAC ATTCTGATGA GCAACCGC1T CCCrA ITAT 7AATTT GTITGTflGT TI7rGAT'rCAT TGGTCTAATT TA'ITCAAAGG GGGCAAGAAG TAGCAGTGTC TGTAAAAGAG CCTAG1TIT AATAGCTATG GAATCAATrC AATrGGACT GGTGTGCTCT aITAAATCA AGTC=WAA TrAAGACTGA AAATATATAA GCTCAGATTA TTAAATGGG AATATITATA AATGAGCAAA TATCATACTG TFCAATGGT7 CTGAAATAAA CTrCACTGAA GAAAAAAAAA AAAGGGTCTC TCCTGATCAT TGACTGTCrG GATrGACACr GACAGTAAGC AAACAGGCTG TGAGAGTrCT TGGGACTAAG CCCACTCCTC A FrGCTGAGT GCTGCAAGTA CCTAGAAATA TCCrrGGCCA CCGAAGACTA TCCTCCTCAC CCATCCCCTr TA Tr7CGT7G ITCAACAGAA GGATAT7CAG TGCACATCTG GAACAGGATC AGCTGAAGCA CTGCAGGGAG TCAGGACTGG TAGTAACAGC TACCATGATT TATCTATCAA TGCACCAAAC ATCTGTTGAG CAAGCGCTAT GTACTAGGAG CTGGGAGTAC AGAGATGAGA ACAGTCACAA GTCCCTCCTC AGATAGGAGA GGCAGCTAGT TATAAGCAGA ACAAGGTAAC ATGACAAGTA GAGTAAGATA GAAGAACGAA GAGGAGTAGC CAGGAAGGAG GGAGGAGAAC GACATAAGAA TCAAGCCTAA AGGGATAAAC AGAAGATTrC CACACATGGG CTGGGCCAAT TGGGTGTCGG TrACGCCTGT AATCCCAGCA CTIGGGTGG CAGGGGCAGA AAGATCGC= GAGCCCAGGA GTTCAAGACC AGCCTGGGCA ACATAGTGAG ACTCCCATCT CTACAAAAAA TAAATAAATA AATAAAACAA TCAGCCAGGC ATGCTGGCAT GCACCTGTAG TCCTAGCTAC T7GGGAAGCT GACACTGGAG WO 00/09525 PCT/US99/17712 EPI-109 196 GATTGCTTGA GCCCAGAAGT TCAAGACTGC AGTGAGCTTA TCCGTTGACC TGCAGGTCGA C-3' (FRAG. NO:_)(SEQ. ID NO:2512) 5'-ACAAACCT TCGAGGCAAA AGGCAAAAAA GGCTGCTCTG GGATTCTCT CAGCCAATCT TCAATGCTCA AGTGTCTGAA GCAGCCATGG CAGAAGTACC TAAGCTCGCC AGTGAAATGA TGGCTTATTA CAGTGGCAAT GAGGATGACT TGTCTITGA AGCTGATGGC CCTAAACAGA TGAAGTGCTC CTTCCAGGAC CTGGACCTCT GCCCTCTGGA TGGCGGCATC CAGCTACGAA TCTCCGACCA CCACTACAGC AAGGGCTTCA GGCAGGCCGC GTCAGTTGTT GTGGCCATGG ACAAGCTGAG GAAGATGCTG GTTCCCTGCC CACAGACCIT CCAGGAGAAT GACCTGAGCA CCTTCTTTCC CTTCATCT GAAGAAGAAC CTATCTTCTT CGACACATGG GATAACGAGG CTTATGTGCA CGATGCACCT GTACGATCAC TGAACTGCAC GCTCCGGGAC TCACAGCAAA AAAGCTTGGT GATGTCTGGT CCATATGAAC TGAAAGCTCT CCACCTCCAG GGACAGGATA TGGAGCAACA AGTGGTGTTC TCCATGTCCT TTGTACAAGG AGAAGAAAGT AATGACAAAA TACCTGTGGC CTTGGGCCTC AAGGAAAAGA ATCTGTACCT GTCCTGCGTG TTGAAAGATG ATAAGCCCAC TCTACAGCTG GAGAGTGTAG ATCCCAAAAA TTACCCAAAG AAGAAGATGG AAAAGCGATT TGTCTTCAAC AAGATAGAAA TCAATAACAA GCTGGAAT GAGTCTGCCC AGTrCCCCAA CTGGTACATC AGCACCTCTC AAGCAGAAAA CATGCCCGTC TTCCTGGGAG GGACCAAAGG CGGCCAGGAT ATAACTGACT TCACCATGCA ATGTGTCT TCCTAAAGAG AGCTGTACCC AGAGAGTCCT GTGCTGAATG TGGACTCAAT CCCTAGGGCT GGCAGAAAGG GAACAGAAAG GT1TIGAGT ACGGCTATAG CCTGGACTTT CCTGTTGTCT ACACCAATGC CCAACTGCCT GCCTTAGGGT AGTGCTAAGA GGATCTCCTG TCCATCAGCC AGGACAGTCA GCTCTCCCT TrCAGGGCCA ATCCCAGCCC T=TTGTrGAG CCAGGCCTCT CTCACCTCTC CTACTCACTT AAAGCCCGCC TGACAGAAAC CAGGCCACAT TTTGGTTCTA AGAAACCCTC CTCTGTCATT CGCTCCCACA TTCTGATGAG CAACCGCTTC CCTATTTATT TATTTATTTG TTGTTGTT TTGATTCATT GGTCTAAMTT ATTCAAAGGG GGCAAGAAGT AGCAGTGTCT GTAAAAGAGC CTAG7TA ATAGCTATGG AATCAATTCA AT1TGGACTG GTGTGCTCTC TITAAATCAA GTCCTTAAT TAAGACTGAA AATATATAAG CTCAGATTAT TTAAATGGGA ATATITATAA ATGAGCAAAT ATCATACTGT TCAATGGTTC TCAAATAAAC TrCACT-3' (FRAG. NO:_)(SEQ. ID NO:2513) 5'-CTGGCAGGAG TAGCAGCTGC CCCrGGCGC GACTGCTGGA GCCGCGAACT AGAGAAACAC AGACACGCCT CATAGAGCAA CGGCGTCTCT CGGAGCGTGG AGCCCGCCAA GCTCGAGCTG AGCTTTCGCT TGCCGTCCAC CACTGCCCAC ACTGTCGTTT GCTGCCATCG CAGACCTGCT GCTGACTTCC ATCCCTCTGG ATCCGGCAAG GGCCTGCGAT TTTGACAATG TCAAGATTTA CCGTATATCC CTGTTTGTT GGATACACCA GTGACGTCCA CTTCTAGAAG ACAAAGTTAT ATrACTrAAA CAACCAAAGA TATGAAACTA TCCATGAAGA ACAATATTAT CAATACACAG CAGTCTITG TAACCATGCC CAATGTGATT GTACCAGATA TTGAAAAGGA AATACGAAGG ATGGAAAATG GAGCATGCAG CTCCITITCT GAGGATGATG ACAGTGCCTC TACATCTGAA GAATCAGAGA ATGAAAACCC TCATGCAAGG GGTTCCTTTA GTTATAAGTC ACTCAGAAAG GGAGGACCAT CACAGAGGGA GCAGTACCTG CCTGGTGCCA TTGCCATTTT TAATGTGAAC AACAGCGACA ATAAGGACCA GGAACCAGAA GAAAAAAAGA AAAAGAAAAA AGAAAAGAAG AGCAAGTCAG ATGATAAAAA CGAAAATAAA AACGACCCAA AGAAGAAGAT GGAAAAGCGA-3' (FRAG. NO:_)(SEQ. ID NO:2514) 5'-ATGGCCAAAG TTCCAGACAT GIT7GAAGAC CTGAAGAACT GTTACAGTGA AAATGAAGAA GACAGTTCCT CCATTGATCA TCTGTCTCTG AATCAGAAAT CCTTCTATCA TGTAAGCTAT GGCCCACTCC ATGAAGGCTG CATGGATCAA TCTGTGTCTC TGAGTATCTC TGAAACCTCT AAAACATCCA AGCTTACCTT CAAGGAGAGC ATGGTGGTAG TAGCAACCAA CGGGAAGGTT CTGAAGAAGA GACGGTTGAG ITAAGCCAA TCCATCACTG ATGATGACCT GGAGGCCATC GCCAATGACT CAGAGGAAGA AATCATCAAG CCTAGGTCAG CACC'TTAG CTTCCTGAGC AATGTGAAAT ACAACTTAT GAGGATCATC AAATACGAAT TCATCCTGAA TGACGCCCTC AATCAAAGTA TAATrCGAGC CAATGATCAG TACCTCACGG CTGCTGCATT ACATAATCTG GATGAAGCAG TGAAATGA CATGGGTGCT TATAAGTCAT CAAAGGATGA TGCTAAAATT ACCGTGATTC TAAGAATCTC AAAAACTCAA TTGTATGTGA CTGCCCAAGA TGAAGACCAA CCAGTGCTGC TGAAGGAGAT GCCTGAGATA CCCAAAACCA TCACAGGTAG TGAGACCAAC CTCCTCTTCT TCTGGGAAAC TCACGGCACT AAGAACTAIT TCACATCAGT TGCCCATCCA AACTTGITA TTGCCACAAA GCAAGACTAC TGGGTGTGCT TGGCAGGGGG GCCACCCTCT ATCACTGACT TTCAGATACT GGAAAACCAG GCGTAGGTCT GGAGTCTCAC TTGTCTCACr TGTGCAGTGT TGACAGTTCA TATGTACCAT GTACATGAAG AAGCTAAATC CITTACTGTr AGTCATTTGC TGAGCATGTA CTGAGCCTTG TAATTCTAAA TGAATGTTTA CACTCTTTGT AAGAGTGGAA CCAACACTAA CATATAATGT TGTrATTTAA AGAACACCCT ATATTTGCA TAGTACCAAT CATAATT ATTATTCrTTC ATAACAATTT TAGGAGGACC AGAGCTACTG ACTATGGCTA CCAAAAAGAC TCTACCCATA TTACAGATGG GCAAATTAAG GCATAAGAAA ACTAAGAAAT ATGCACAATA GCAGTTGAAA CAAGAAGCCA CAGACCTAGG AT'ITCATGAT TrCATTCAA CTGTTGCCT TCTGCTITrA AGTTGCTGAT GAACTCTTAA TCAAATAGCA TAAG=TTCTG GGACCTCAGT TATCATTT TCAAAATGGA GGGAATAATA CCTAAGCCTT CCTGCCGCAA CAG111111A TGCTAATCAG GGAGGTCATT TTGGTAAAAT ACTTCTCGAA GCCGAGCCTC AAGATGAAGG CAAAGCACGA AATGTTATIT TTAATTATT ATTTATATAT GTATTTATAA ATATATTTAA GATAATTATA ATATACTATA TTTATGGGAA CCCCTTCATC CTCTGAGTGT GACCAGGCAT CCTCCACAAT AGCAGACAGT GITTCTGGG ATAAGTAAGT TTGATMTCAT TAATACAGGG CATTGGTC CAAGTTGTGC TTATCCCATA GCCAGGAAAC TCTGCATTCT AGTACTTGGG AGACCTGTAA TCATATAATA AATGTACATT AATTACCTTG AGCCAGTAAT TGGTCCGATC TTGACTCTT TTGCCATrAA ACTTACCTGG GCATTCTTGT TTCATrCAAT TCCACCTGCA ATCAAGTCCT ACAAGCTAAA ATTAGATGAA CTCAACTTG ACAACCATAG ACCACTGTTA TCAAAACTTT CTITCTGGA ATGTAATCAA TGTCTTCT AGGTTCTAAA AATTGTGATC AGACCATAAT GTTACATTAT TATCAACAAT AGTGATTGAT AGAGTGTTAT CAGTCATAAC TAAATAAAGC TTGCAAGTGA GGGAGTCATT TCATTGGCGT TTGAGTCAGC AAAGAAGTCA AG-3' (FRAG. NO:_)(SEQ. ID NO:2515) 5'-AGCTGCCAGC CAGAGAGGGA GTCATTTCAT TGGCGTTGA GTCAGCAAAG AAGTCAAGAT GGCCAAAGTT CCAGACATGT TTGAAGACCT GAAGAACTGT TACAGTGAAA ATGAAGAAGA CAGTrCCTCC ATTGATCATC TGTCTCTGAA TCAGAAATCC TTCTATCATG TAAGCTATGG CCCACTCCAT GAAGGCTGCA TGGATCAATC TGTGTCTCTG AGTATCTCTG AAACCTCTAA AACATCCAAG CTTACC TTCA AGGAGAGCAT GGTGGTAGTA GCAACCAACG GGAAGGTrCT GAAGAAGAGA CGGTTGAGTT TAAGCCAATC CATCACTGAT GATGACCTGG AGGCCATCGC CAATGACTCA GAGGAAGAAA TCATCAAGCC TAGGTCATCA CCFI11AGCT TCCTGAGCAA TGTGAAATAC AACTATGA GGATCATCAA ATACGAATTC ATCCTGAATG WO 00/09525 PCT/US99/1 7712 ACGCCCTCAA TCAAAGTATA ATTCGAGCCA ATGATCAGTA CCTCACGGCT GCTGCA'FrAC ATAATCTGGA TGAAGCAGTG AAA ITGACA TGGGTGCTTA TAAGTCATCA AAGGATGATG CTAAAATFAC CGTGATTCTA AGAATCTCAA AAACTCAATr GTATGTGACT GCCCAAGATG AAGACCAACC AcITGCTGCTG AAGGAGATGC CTGAGATACC CAAAACCATC ACAGGTAGTG AGACCAACCT CCTCrrCTTC TGGGAAACTC ACGGCACTAA GAACTA'TrTC ACATCAGTrG CCCATCCAAA CTTG ITIrAf GCCACAAAGC AAGACTACTrG GGTGTGCITG GCAGGGGGGC CACCCTCTAT CACTGAC=r CAGATACTGG AAAACCAGGC GTAGGTCTGG AGTCrCAC'Tr GTCTCACTTG TGCAGTGTrG ACAG ITCATA TGTACCATGT ACATGAAGAA GCTAAATCCT T'rACTGTTAG TCATrGCTG AGCATGTACT GAGCCITGTA A'ITCTAAATG AATGTIACA CT'I I IGTAA GAGTGGAACC AACACTAACA TATAATGTTG TrAT"ITAAAG AACACCCTAT ATI=GCATA GTACCAATCA TMTAATrAT TATrcTlrCAT AACAATITA GGAGGACCAG AGCTACTGAC TATGGCTACC AAAAAGACTC TACCCATATT ACAGATGGGC AAATTAAGGC ATAAGAAAAC TAAGAAATAT GCACAATAGC AGTCGAAACA AGAAGCCACA GACCTAGGAT TTCATGAM~ CAM~CAACT GMfGCCT7C TGClI I IAAG TTGCTGATGA ACTCTTAATC AAATAGCATA AG'I=CTGGG ACCTCAGTT7 TATCATITC AAAATGGAGG GAATAATACC TAAGCCT7CC TGCCGCAACA GTITITATG CTAATCAGGG AGGTCATIT GGTAAAATAC TTCTCGAAGC CGAGCCTCAA GATGAAGGCA AAGCACGAAA TGTTA TITM TAATTATTAT TrATATATGT ATIATAAAT ATATIAAGA TAATTATAAT ATACTATATT TATGGGAACC CC'rCATCCT CTGAGTGTGA CCAGGCATCC TCCACAATAG CAGACAGTGT TICTGGGAT AAGTAAGTI' GA TrCATrA ATACAGGGCA TITGGTCCA AGTrGTGCTr ATCCCATAGC CAGGAAACTrC TGCATTCrAG TACTTGGGAG ACCTGTAATC ATATAATAAA TGTACATTAA TTACMTGAG CCAGTAATrG GTCCGATCTT TGACTCTI GCCATTAAAC TTACCTGGGC ATrrGTrr CATrCAATTC CACCTGCAAT CAAGTCCTAC AAGCTAAAAT TAGATGAACT CAA=rrGAC AACCATGAGA CCACTGTrAT CAAAAC'I=C rITGGAA TGTAATCAAT G'rrCTrCTA GGIrCTAAAA ATrGTGATCA GACCATAATG TrACATT'- ATCAACAATA GTGATTGATA GAGTGT7ATC AGTCATAACT AAATAAAGCT TGCAACAAAA TCTCITG-3' (FRAG. NO:_)(SEQ. ID NO:2516) Human Interleukin-1 Receptor (IL-i R) Nucleic Acids and Anti-sense Oligonucleotide Fragments 5'-GCCACGTGCT GCTGGGTC7TC AGTCCTCCAC TrCCCGTGTC CrCTrGGAAGT TGTCAGGAGC AATG'ITGCGC TTGTACGTGT TGGTAATGGG AGTI7rTGCC T7CACCCTC AGCCTGCGGC ACACACAGGG GCTGCCAGAA GCTrGCCGGfl7 TCGTGGGAGG CATTACAAGC GGGAGTTCAG GCTGGAAGGG GAGCCTGTAG CCCTGAGGTG CCCCCAGGTG CCCTACTGGT TGTGGGCCTC TGTCAGCCCC CGCATCAACC TGACATGGCA TAAAAATGAC TCTGCTAGGA CGGTCCCAGG AGAAGAAGAG ACACGGATGT GGGCCCAGGA CGGTGCTCrG TGGCT-CTGC CAGCCTrGCA GGAGGACTCT GGCACCrACG TCTrGCACTAC TAGAAATGCT TC'IrACTGTG ACAAAATGTC CATTGAGCTC AGAG'TI=G AGAATACAGA TGCTICCTG CCGTrCATcT CATACCCGCA AATITAACC T7GTCAACCT CTGGGGTATT AGTATGCCCT GACCTGAGTG AATTCACCCG TGACAAAACT GACGTGAAGA TTCAATGGTA CAAGGATTrT CTrCITIGG ATAAAGACAA TGAGAAAMT CTAAGTGTGA GGGGGACCAC TCACTrAC7C GTACACGATG TGGCCCTGGA AGATGCTGGC TAT7ACCGCr GTGTCCTGAC A'IMGCCCAT GAAGGCCAGC AATACAACAT CACTAGGAGT ATTGAGCTAC GCATCAAGAA AAAAAAAGAA GAGACCATrC CTGTGATCAT ITCCCCCCTrC AAGACCATAT CAGCITCrCT GGGGTCAAGA CTGACAATCC CGTGTAAGGT G ITCTGGGA ACCGGCACAC CMTAACCAC CATGCTGTGG TGGACGGCCA ATGACACCCA CATAGAGAGC GCCTACCCGG GAGGCCGCGT GACCGAGGGG CCACGCCAGG AATAT7CAGA AAATAATGAG AACTACATTG AAGTGCCATr GA TTGAT CCTGTCACAA GAGAGGAT= GCACATGGAT 7ITIAAATGTG 'ITGTCCATAA TACCCTGAGT 717CAGACAC TACGCACCAC AGTCAAGGAA GCCTCCTCCA CGTrCTrCCTG GGGCAT7GTG CTGGCCCCAC 'ITrCACTGGC CTTCrGGIr TrGGGGGGAA TATGGATGCA CAGACGGTGC AAACACAGAA CTGGAAAAGC AGATGGTCTG ACTGTGCTAT GGCCTCATCA TCAAGAC'= CAATCCTATC CCAAGTGAAA TAAATGGAAT GAAATAAT7C AAACACAAAA AAAAAAAAAA AAAAAAAA GCCGGAGCCG ACTCGGAGCG CGCGGCGCGG CCGGGAGGAG CCGAGCGCGC CGGGCGCGGC GTGGGGGCGC CGGCTGCCCC GCGCGCCCAG GGAGCGGCAG GAATGTGACA ATCGCGCGCC CGCACCGTAG CACTCCTCGC TCGGCTrCCTA GGGCTCTCGC CCTCTGAGCT GAGCCGGGT7 CCGCCCGGGC TGGGATCCCA TCACCCTCCA CGGCCGTCCG TCCAGGTAGA CGCACCCTrCT GAAGATGGTG ACTCCCTCCT GAGAAGCTGG ACCCCITGGT AAAAGACAAG GCCT'rCTCCA AGAAGAATAT GAAAGTGTrA CTCAGAC'rrA M~GMICAT AGCrCTrACTG A T~TlCTC TGGAGGCTGA TAAATGCAAG GAACGTGAAG AAAAAATAAT 'ITrAGTGTCA TCTGCAAATG AAATrGATGT TCGTCCCTGT CCTCTAACC CAAATGAACA CAAAGGCACT ATAACTGGT ATAAAGATGA CAGCAAGACA CCTrGTATCTA CAGAACAAGC CTCCAGGAT7 CATCAACACA AAGAGAAACT TrGGM~GTF CCrGCTAAGG TGGAGGATf C AGGACATTAC TATrGCGTGG TAAGAAATrC ATCTrACTGC CTCAGAAYrA AAATAAGTGC AAAATITGTG GAGAATGAGC CTAACTATG TrATAATGCA CAAGCCATAT T'rAAGCAGAA ACTACCCGTr GCAGGAGACG GAGGACT7GT GTGCCCITAT ATGGAGT=1T TAAAAATGA AAATAATGAG T7ACCTAAAT TACAGTGGTA TAAGGATrGC AAACCTCTAC TrCrGACAA TATACACIT AGTGGAGTCA AAGATAGGCT CATCGTGATG AATGTGGCTG AAAAGCATAG AGGGAACrAT ACT7GTCATG CATCCTrACAC ATACTGGGC AAGCAATATC CTrATrACCCG GGTAATAGAA '1ATFACTC TAGAGGAAAA CAAACCCACA AGGCCTrGTGA TTGTGAGCCC AGCTAATGAG ACAATGGAAG TAGAC'ITGGG ATCCCAGATA CAA ITGATCr GTAATGTCAC CGGCCAGTrG AGTGACAUrG =rACrGGAA GTGGAATGGG TCAGTAAITG ATGAAGATGA CCCAGTGCTA GGGGAAGACT ATTACAGTGT GGAAAATCCT GCAAACAAAA GAAGGAGTAC CCTCATCACA GTGCITAATA TATCGGAAAT TGAAAGTAGA T1TATAAAC ATCCATIAC CrGTITGCC AAGAATACAC ATGGTATAGA TGCAGCATAT ATCCAGTrAA TATATCCAGT CACTAA ITC CAGAAGCACA TGA'rTGGTAT ATGTGTCACG TrGACAGTCA TAATTGTGTG TTCTGTITC ATCTATAAAA TCT~rCAAGAT TGACAT-rGTG CITGGTACA GGGA ITCCTG CTATGATT7 CTCCCAATAA AAGCITCAGA TGGAAAGACC TATGACGCAT ATATACTGTA TCCAAAGACT GTTGGGGAAG GGTCTACCTC TGACTGTGAT ATITIGTGT TrAAAGTCTT GCCTGAGGTC TrGGAAAAAC AGTGTGGATA TAAGCTGTTC A'IMATGGAA GGGATGACTA CGTTGGGGAA GACATrGTTG AGGTCA'ITAA TGAAAACGTA AAGAAAAGCA GAAGACTGAT TATCATITA GTCAGAGAAA CATCAGGCTT CAGCTGGCTG GGTGG'ITCAT CTGAAGAGCA AATAGCCATG TATAATGCTC TTGTrCAGGA TGGAATTAAA GTTGTCCTGC TTGAGCrGGA GAAAATCCAA GACrATGAGA AAATGCCAGA ATCGATTAAA TTCA'ITAAGC AGAAACATGG GGCrATCCGC TGGTCAGGGG ACI1ACACA GGGACCACAG TCTGCAAAGA CAAGGTrCrG GAAGAATGTC AGGTACCACA TGCCAGTCCA GCGACGGTCA CCTrCATCTA AACACCAG17 ACrGTCACCA GCCACTAAGG AGAAACTGCA AAGAGAGGCT CACGTGCCTC TCGGGTAGCA TGGAGAAG17 GCCAAGAGT ='~AGGTGC CTCCTGTCTT ATGGCGTrGC AGGCCAGG117 ATGCCTCATG CTGACTGCA GAGT7CATGG AATGTAACTA TATCATCCM TATCCCTGAG GTCACCAGGA ATCAGG-3' (FRAG. NO:_)(SEQ. ID NO:2521) WO 00/09525 PCT/US99/17712 EPI-109 198 5'-GCCACGTGCT GCTGGGTCTC AGTCCTCCAC TTCCCGTGTC CTCTGGAAGT TGTCAGGAGC AATGTTGCGC TTGTACGTGT TGGTAATGGG AGTTrCTGCC TTCACCCTTC AGCCTGCGGC ACACACAGGG GCTGCCAGAA GCTGCCGGTT TCGTGGGAGG CATTACAAGC GGGAGTrCAG GCTGGAAGGG GAGCCTGTAG CCCTGAGGTG CCCCCAGGTG CCCTACTGGT TGTGGGCCTC TGTCAGCCCC CGCATCAACC TGACATGGCA TAAAAATGAC TCTGCTAGGA CGGTCCCAGG AGAAGAAGAG ACACGGATGT GGGCCCAGGA CGGTGCTCTG TGGCTTCTGC CAGCCTTGCA GGAGGACTCT GGCACCTACG TCTGCACTAC TAGAAATGCT TCT7ACTGTG ACAAAATGTC CATTGAGCTC AGAGITIllG AGAATACAGA TGCTTTCCTG CCGITCATCT CATACCCGCA AATTTTAACC T7GTCAACCT CTGGGGTATT AGTATGCCCT GACCTGAGTG AATTCACCCG TGACAAAACT GACGTGAAGA TrCAATGGTA CAAGGATrCT CTrClI iGG ATAAAGACAA TGAGAAATTT CTAAGTGTGA GGGGGACCAC TCACTTACTC GTACACGATG TGGCCCTGGA AGATGCTGGC TATTACCGCT GTGTCCTGAC ATTTGCCCAT GAAGGCCAGC AATACAACAT CACTAGGAGT ATTGAGCTAC GCATCAAGAA AAAAAAAGAA GAGACCATTC CTGTGATCAT TTCCCCCCTC AAGACCATAT CAGCTTCTCT GGGGTCAAGA CTGACAATCC CGTGTAAGGT G'1TTCTGGGA ACCGGCACAC CCTTAACCAC CATGCTGTGG TGGACGGCCA ATGACACCCA CATAGAGAGC GCCTACCCGG GAGGCCGCGT GACCGAGGGG CCACGCCAGG AATATTCAGA AAATAATGAG AACTACATTG AAGTGCCATT GATITTGAT CCTGTCACAA GAGAGGATTT GCACATGGAT TTTAAATGTG TTGTCCATAA TACCCTGAGT 'TTCAGACAC TACGCACCAC AGTCAAGGAA GCCTCCTCCA CGTTCTCCTG GGGCATrGTG CTGGCCCCAC TrCACTGGC CTTCTTGGTT TGGGGGGAA TATGGATGCA CAGACGGTGC AAACACAGAA CTGGAAAAGC AGATGGTCTG ACTGTGCTAT GGCCTCATCA TCAAGACTTT CAATCCTATC CCAAGTGAAA TAAATGGAAT GAAATAATTC AAACACAAAA AAAAAAAAAA AAAAAAAA- 3' (FRAG. NO:_)(SEQ. ID NO:2518) 5'-GCCGGAGCCG ACTCGGAGCG CGCGGCGCGG CCGGGAGGAG CCGAGCGCGC CGGGCGCGGC GTGGGGGCGC CGGCTGCCCC GCGCGCCCAG GGAGCGGCAG GAATGTGACA ATCGCGCGCC CGCACCGTAG CACTCCTCGC TCGGCTCCTA GGGCTCTCGC CCTCTGAGCT GAGCCGGGTT CCGCCCGGGC TGGGATCCCA TCACCCTCCA CGGCCGTCCG TCCAGGTAGA CGCACCCTCT GAAGATGGTG ACTCCCTCCT GAGAAGCTGG ACCCCTTGGT AAAAGACAAG GCCTTCTCCA AGAAGAATAT GAAAGTGTTA CTCAGACTTA TTTGTTTCAT AGCTCTACTG ATTTCTrCTC TGGAGGCTGA TAAATGCAAG GAACGTGAAG AAAAAATAAT TTTAGTGTCA TCTGCAAATG AAATTGATGT TCGTCCCTGT CCTCTTAACC CAAATGAACA CAAAGGCACT ATAACTTGGT ATAAAGATGA CAGCAAGACA CCTGTATCTA CAGAACAAGC CTCCAGGATT CATCAACACA AAGAGAAACT TTGGTTTGTT CCTGCTAAGG TGGAGGATTC AGGACATTAC TATTGCGTGG TAAGAAATTC ATCTTACTGC CTCAGAATTA AAATAAGTGC AAAATTTGTG GAGAATGAGC CTAACTTATG TTATAATGCA CAAGCCATAT TTAAGCAGAA ACTACCCGTT GCAGGAGACG GAGGACTTGT GTGCCCTTAT ATGGAGTT TTAAAAATGA AAATAATGAG TTACCTAAAT TACAGTGGTA TAAGGATTGC AAACCTCTAC TTCTTGACAA TATACACTTT AGTGGAGTCA AAGATAGGCT CATCGTGATG AATGTGGCTG AAAAGCATAG AGGGAACTAT ACTTGTCATG CATCCTACAC ATACTTGGGC AAGCAATATC CTATrACCCG GGTAATAGAA T'ITATTACTC TAGAGGAAAA CAAACCCACA AGGCCTGTGA TTGTGAGCCC AGCTAATGAG ACAATGGAAG TAGACTTGGG ATCCCAGATA CAATTGATCT GTAATGTCAC CGGCCAGTTG AGTGACATTG CTTACTGGAA GTGGAATGGG TCAGTAATTG ATGAAGATGA CCCAGTGCTA GGGGAAGACT ATTACAGTGT GGAAAATCCT GCAAACAAAA GAAGGAGTAC CCTCATCACA GTGCTTAATA TATCGGAAAT TGAAAGTAGA TTTATAAAC ATCCATTAC CTGTTGCC AAGAATACAC ATGGTATAGA TGCAGCATAT ATCCAGTTAA TATATCCAGT CACTAATTTC CAGAAGCACA TGATrGGTAT ATGTGTCACG TTGACAGTCA TAATTGTGTG TTCTGTTC ATCTATAAAA TCTTCAAGAT TGACATTGTG CITTGGTACA GGGATTCCTG CTATGATTTT CTCCCAATAA AAGCTTCAGA TGGAAAGACC TATGACGCAT ATATACTGTA TCCAAAGACT GTTGGGGAAG GGTCTACCTC TGACTGTGAT AFT IGTGT TTAAAGTCTT GCCTGAGGTC TTGGAAAAAC AGTGTGGATA TAAGCTGTTC ATTTATGGAA GGGATGACTA CGTrGGGGAA GACATTGTTG AGGTCATrAA TGAAAACGTA AAGAAAAGCA GAAGACTGAT TATCATTTTA GTCAGAGAAA CATCAGGCTr CAGCTGGCTG GGTGGTTCAT CTGAAGAGCA AATAGCCATG TATAATGCTC TTGTTCAGGA TGGAATTAAA GTTGTCCTGC TTGAGCTGGA GAAAATCCAA GACTATGAGA AAATGCCAGA ATCGATTAAA TrCATTAAGC AGAAACATGG GGCTATCCGC TGGTCAGGGG ACITTACACA GGGACCACAG TCTGCAAAGA CAAGGTTCTG GAAGAATGTC AGGTACCACA TGCCAGTCCA GCGACGGTCA CCTTCATCTA AACACCAGTT ACTGTCACCA GCCACTAAGG AGAAACTGCA AAGAGAGGCT CACGTGCCTC TCGGGTAGCA TGGAGAAGTT GCCAAGAGTT C'TAGGTGC CTCCTGTCTT ATGGCGTTGC AGGCCAGGTT ATGCCTCATG CTGACTTGCA GAGTTCATGG AATGTAACTA TATCATCCT TATCCCTGAG GTCACCAGGA ATCAGG-3' (FRAG. NO:_)(SEQ. ID NO:2519) Human Intereukin-8* Fragments Antisense Oligonucleotide Fragments 5'-GBTGTrTGTT BCCBBBGCBT CBBGBBTBGC TTTGCTBTCT BBGGBTCBCB TTTBGBCBTB GGBBBBCGCT GTBGGTCBGBB BGBTGTGCTT BCCTTCBCBC BGBGCTGCBG BBBTCBGGBBGG CTGCCBBGBGBG CCBCGGCCBGC TTGGBGTCBT GTTTBCBCBC BGTGBGGTGC TCCGGTGGCT TTTTGCTTGT GTGCTCTGCT GTCTCTG TTC CrCCGGTGG TTCTTCCTG GCTCTTGTCC TTTCTCTrGG CCCTTGGCCC-3' (FRAG. NO:1834) (SEQ. ID NO:1845) 5'-G CTC CGG-3' (FRAG. NO:1835) (SEQ. ID NO:1846) 5'-CBBGBBTBGC-3' (FRAG. NO:1836) (SEQ. ID NO:1847) 5'-CBCBC BGTGBGGTGC-3' (FRAG. NO:1837) (SEQ. ID NO:1848) 5-BCCBBBGCBT CBBGBBTBGC-3' (FRAG. NO:1838) (SEQ. ID NO:1849) 5'-GCCBBGBGBG CCBCGGCCBGC-3' (FRAG. NO:1839) (SEQ. ID NO:1850) 5'-GTG CTC CGG TGG CTT TTT-3' (FRAG. NO:1289)(SEQ. ID NO:1299) 5'-GCT TGT GTG CTC TGC TGT CTC TG-3' (FRAG. NO:1290)(SEQ. ID NO:1300) 5'-'TrC CTT CCG GTG GTT TCT TCC TGG CTC TTG TCC T-3' (FRAG. NO:1291)(SEQ. ID NO:1301) 5'-TT'C TCT TGG CCC TTG GCC C-3' (FRAG. NO:1292)(SEQ. ID NO:1302) 5-GBTGTITGTr BCCBBBGCBT CBBGBBTBGC TTGCTBTCT BBGGBTCBCB TTTBGBCBTB GGBBBBCGCT GTBGGTCBGBB BGBTGTGCTT BCCTTCBCBC BGBGCTGCBG BBBTCBGGBBGG CTGCCBBGBGBG CCBCGGCCBGC TTGGBGTCBT GTTTBCBCBC BGTGBGGTGC TCCGGTGGCT TI rGCTrGT-3' (FRAG. NO:1840) (SEQ. ID NO:1851) Human IL-8 Receptor Alpha Antisense Oligonucleotide Fragments 5'-ACAGGGGCTG TAATCTTCATC TGCAGGTGGC ATGCCAGTGA AATAGATC ATCAAAATCC CACATCTGTG GATCTGTAAT ATTTGACATG TCCTCTTCAG TTrCAGCAAT GGTTGATCT AACTGAAGCA CCGGCCAGGB CBGGGGCTGT BBTCTTCBTC TGCBGGTGGC BTGCCBGTGB BBTTTBGBTC BTCBBBBTCC CBCBTCTGTG GBTCTGTBBT BMTTGBCBTG TCCTCTTCBG ITTCBGCBB TGGTTTGBTC TBBCTGBBGC BCCGGCCBGG TGGCTCGGTG CTTCTGCCCC TGTrGTTGCG GCGCTCGGTT GGTGTGGCCC CTGTGGTGCT TCGTCCCC CTCTTTCTCT TTGTTCGGGG GTTCTrGTGG CGGGCTGCTT GTCTCGTrCC-3' WO 00/09525 PCT/US99/17712 EPI-109 199 (FRAG. NO:1841) (SEQ. ID NO:1852) 5'-CBGGGGC-3' (FRAG. NO:1842) (SEQ. ID NO:1853) 5'-GCBGGTGGC-3' (FRAG. NO:1843) (SEQ. ID NO:1854) 5'-GCGGCGCTC-3' (FRAG. NO:1844) (SEQ. ID NO:1855) 5'-TGGCTCGGTGCTTCTGCCCC (FRAG. NO:1293)(SEQ. ID NO:1303) 5'-TGTTGTTGCGGCGCTC (FRAG. NO:1294)(SEQ. ID NO:1304) 5'-GGTTGGTGTGGCCCCTG (FRAG. NO:1295)(SEQ. ID NO:1305) 5'-TGGTGCTTCGTCC (FRAG. NO:1296)(SEQ. ID NO:1306) 5'-CCCTCTTCTCTTGTrC FRAGG. NO:1297)(SEQ. ID NO:1307) 5'-GGGGGTrCTTGTGGC (FRAG. NO:1298)(SEQ. ID NO:1308) 5'-GGGCTGCTTGTCTCGTTCC (FRAG. NO:1299)(SEQ. ID NO:1309) 5'-ACAGGGGCTG TAATCTTCATC TGCAGGTGGC ATGCCAGTGA AATTTAGATC ATCAAAATCC CACATCTGTG GATCTGTAAT ATGACATG TCCTCTTCAG TCAGCAAT GGTITGATCT AACTGAAGCA CCGGCCAGG-3' (FRAG. NO:1845) (SEQ. ID NO:1856) 5'-B CBGGGGCTGT BBTCTTCBTC TGCBGGTGGC BTGCCBGTGB BBTTTBGBTC BTCBBBBTCC CBCBTCTGTG GBTCTGTBBT B'TTGBCBTG TCCTCTTCBG ITTCBGCBB TGGTTTGBTC TBBCTGBBGC BCCGGCCBGG-3' (FRAG. NO:1846) (SEQ. ID NO:1857) Interleukin-11 (IL-11) Nucleic Acid and Antisnese Oligonucleotide Fragments 5'-GCTCAGGGCA CATGCCTCCC CTCCCCAGGC CGCGGCCCAG CTGACCCTCG GGGCTCCCCC GGCAGCGGAC AGGGAAGGGT TAAAGGCCCC CGGCTCCCTG CCCCCTGCCC TGGGGAACCC CTGGCCCTGT GGGGACATGA ACTGTGTG CCGCCTGGTC CTGGTCGTGC TGAGCCTGTG GCCAGATACA GCTGTCGCCC CTGGGCCACC ACCTGGCCCC CCTCGAGT CCCCAGACCC TCGGGCCGAG CTGGACAGCA CCGTGCTCCT GACCCGCTCT CTCCTGGCGG ACACGCGGCA GCTGGCTGCA CAGCTGAGGG ACAAATTCCC AGCTGACGGG GACCACAACC TGGATTCCCT GCCCACCCTG GCCATGAGTG CGGGGGCACT GGGAGCTCTA CAGCTCCCAG GTGTGCTGAC AAGGCTGCGA GCGGACCTAC TGTCCTACCT GCGGCACGTG CAGTGGCTGC GCCGGGCAGG TGGCTCTTCC CTGAAGACCC TGGAGCCCGA GCTGGGCACC CTGCAGGCCC GACTGGACCG GCTGCTGCGC CGGCTGCAGC TCCTGATGTC CCGCCTGGCC CTGCCCCAGC CACCCCCGGA CCCGCCGGCG CCCCCGCTGG CGCCCCCCTC CTCAGCCTGG GGGGGCATCA GGGCCGCCCA CGCCATCCTG GGGGGGCTGC ACCTGACACT TGACTGGGCC GTGAGGGGAC TGCTGCTGCT GAAGACTCGG CTGTGACCCG GGGCCCAAAG CCACCACCGT CCTTCCAAAG CCAGATCTTA TA ATT TATTTCAGTA CTGGGGGCGA AACAGCCAGG TGATCCCCCC GCCATTATCT CCCCCTAGTT AGAGACAGTC CTTCCGTGAG GCCTGGGGGA CATCTGTGCC TTATTTATAC TTATTTAT CAGGAGCAGG GGTGGGAGGC AGGTGGACTC CTGGGTCCCC GAGGAGGAGG GGACTGGGGT CCCGGATTCT TGGGTCTCCA AGAAGTCTGT CCACAGACTT CTGCCCTGGC TCTTCCCCAT CTAGGCCTGG GCAGGAACAT ATATTATTTA TFTAAGCAAT TACTITTCAT GTTGGGGTGG GGACGGAGGG GAAAGGGAAG CCTGGGTT TGTACAAAAA TGTGAGAAAC CTTTGTGAGA CAGAGAACAG GGAATTAAAT GTGTCATACA TATCC CAGCTGCGGC ATCCTCTGTC TCAGAGTCTT GGTGTCTCTG TTCCTTCCC CTCGGGGTCT CCCTGGGTCT CCCCAAGTCC CTCCTGCTGT CTTCCTCCCG CTCTCTGATC TCTGACTCCC AGAACCTCTC CCTCTGTCTC CAGGGCTGCC CCTCTGATCC TCTGCTTC TCTGGTGTGT CTCTCTGGCT GCCTCCATCT CTGTGGATCT CCGTCTCCCT GTCTCTGTCT CAGTCTGTCC TTCACTCTGT GTGTGTGTGT GTCTCTCTCT CTCTCTCTCC TTCCCFTCCA CTCCCTCTTC CTCCTGCCTC CACCTCTCCA GGCCCCTGTC TTGTCCCTCC GTCCGGCCTT TCTCTGCCTT TCCGTCCTCC TGCCTCCCCA TCTCTCTCTG CTAGTCCTGT CCAGCCGGAC CCCCACCCAC AGTCGGGCCC CAGCGCTTGA GCCTGAGTGT CTGCTCCGGC CCGTGGAGGT GGAGGGAGGG GACGCCAATG ACCTCACCAG CCCCTCTCCG ACCACCCCCC CCTTTCCCTr TTCAACT111 CCAACTTC CTTCCGTGCC CTCCTCCGAG CGCGGCGGCG TGAGCCCTGC AAGGCAGCCG CTCCGTCTGA ATGGAAAAGG CAGGCAGGGA GGGTGAGTCA GGATGTGTCA GGCCGGCCCT CCCCTGCCGC CTGCCCCCCG CCCGCCCGCC CCAGGCCCCC TATATAACCC CCCAGGCGTC CACACTCCCT CACTGCCGCG GGCCCTGCTG CTCAGGGCAC ATGCCTCCCC TCCCCAGCCG CGGGCCCAGC TGACCCTCGG GGCTCCCCCG GCAGCGGACA GGGAAGGGTT AAAGGCCCCC GGCTCCCTGC CCCCTGCCCT GGGGAACCCC TGGCCCTGTG GGGACATGAA CTGTAAGTTG GTTCATGGGG AGGGTGGAGG GGACAGGGAG GCAGGGAGGA GAGGGACCCA CGGCGGGGGT GGGAGCAGAC CCCGCTGAGT CGCACAGAGA GGGACCCGGA GACAGGCAGC CGGGGAGGAG AGCAGCTTCG GAGACAGGAG GCGGCGGAGG AGATGGGCAG AGAGAGACAC AGACAGGAGC GGATGGAGGC AGCCAATCAG AGGCGCCGCA GGAGGGACGG GCCAGACAGG GCCCGAGAGG AGCGAGACGC GAGACCGAGC AGGGGCAGGG ACGCAGGGAC TGGTGCCGGG AGGGAGGTGA CCCCCATCGA CCCAGGCCCC AGGGAGCCCG CGGGGACCGG GAGACTCCCT GGGATTCCGG CAGAGAGGCT CCGGAGGGAA ACTGAGGCAG GGTCCGCGGA GAGCGGAGCA AGCCAGGGAG TAGCGACCCC AGCCGGGGGG AGGAGAGAGA CTGGGCGCCG GGGGAAAGCG GGGAGAGCCG GGCAGATGCG GCCGACGGAG GCGCGGACAG ACCGACGGCT GGCGGGCCCG GGGGGCGGGC TGGGGGTGTG CGAGGCGCGG GCGGCCGGGG AGCGCTGATr GGCTGGCGGG TGGCCGGGTG GGCGGGGCGG CCGGGGTGGG CTGCGGGGAG CGAGCTCCGG ACCCCCGCGC CCCCGGCGCC CCCCGCGCCC CCCGCCGCCA GCTCTCCCGC TCCCGGCGCC CGGCCGGGCC ATGGCTCTGC CCCTCTCCGC CCAGGTGCGC TGCGGCCCGG GCTTCTGCCG CCCACCCGGC GGGCTCCTGG GAGGGCGTCT AAGGGGTCTC CCGTGGGAGA GGTCCGTGTC TCCCGGACTC CGTCCTGGGC TTTTGGCTCC TTCCCCTGCT CCCAGCCAGC TCGGGCTCCC GCGGCCCGGG GAGGGGGCAG GTTCTGGCCT GTGCCTCCCC CACCATCCGC GCCCCGGGGC CCAGATTCCG GCGTCCGGGG GCGGACGGGA GACGCCCGGG CCGCGTCTGC TCCGACGGGC GGGGCAGCCA GAGCCAGGGA GGGAGAGGGA AGCCCGCCTG GCCCTGCGAC CTGCCCGCGG GCGTTCCACC CTGGGACTTA AGACCTCCAG CTCCATCCTC CCTAAGGCCG GGAGTCCAGG CCCCAGACCC TCCTCCCCGA GACCCAGGAG TCCAGACCCC AGGCCTTCCT CCCTCAGACC TAGGAGTCCA GGCCCCCAGC WO 00/09525 PCT/US99/17712 EPI-109 200 CTCTCCTCCC TCAGACCCAG GAGGAGTCCA GACCCCAGTT CCTCCTCCCT CAGACCCGGG AGTCCAGCCC AGGCCCTCCT CTCTCAGACC CGGAGTCCAG CCTGAGCTCT CTGCCTTATC CTGCCCCCAG GTGTTGCCG CCTGGTCCTG GTCGTGCTGA GCCTGTGGCC AGATACAGCT GTCGCCCCTG GGCCACCACC TGGCCCCCCT CGAGTTTCCC CAGACCCTCG GGCCGAGCTG GACAGCACCG TGCTCCTGAC CCGCTCTCTC CTGGCGGACA CGCGGCAGCT GGCTGCACAG CTGGTAGGAG AGACTGGGCT GGGGCCAGCA CAGGAGTGAG AGGCAGAGAG GAACGGAGAG GAGTCTGCGG GCAGCCACTT GGAGGGGTTC TGGGCTCTCA GGTGGCAGAG TGAGGGAGGG GAAGAGTTGG GGGCCTGGCG TGGGGGATGG AGGGAGCCCC GAGGCTGGGC AGGGGCCACC TCACAGCTTT TTTCCCTGCC AGAGGGACAA ATTCCCAGCT GACGGGGACC ACAACCTGGA TTCCCTGCCC ACCCTGGCCA TGAGTGCAGG GGCACTGGGA GCTCTACAGG TAAGGGCAAG GGAGTGGGCT GGGGACAAGG TGGGAGGCAG GCAGTGAAGG GGGCGGGGAG GATGAGGGGC ACTGGTCGGG TGTrCTCTGA TGTCCCGGCT CTATCCCCAG CTCCCAGGTG TGCTGACAAG GCTGCGAGCG GACCTACTGT CCTACCTGCG GCACGTGCAG TGGCTGCGCC GGGCAGGTGG CTCTTCCCTG AAGACCCTGG AGCCCGAGCT GGGCACCCTG CAGGCCCGAC TGGACCGGCT GCTGCGCCGG CTGCAGCTCC TGGTATGTCC TGGCCCCAAG ACCTGACACC CCAGACCCCC ACCCCTGGCC CCAAAATCCT GTGGCCTGAG TCCTTGAAGC CTGAGACCCC AGACCCGAGT GCAACAGCCC CGCTCTGAGA CCCTGACACC CTAACAGCCC GCTCTGAGAC CCTGACACCG TAACAGCCCC GCTCTGAGAC CCTGACCCTA ACAGTCCTGC TCTGAGACCC TGACCCTGCA GTCCCAAGAT CCTGTGGCCC TGAGACCCTG AGGCCCTAGA CCCCCAAATC CTGCCCAGAA ACTTCAAATT CTCACCCAAG ACCCTGAGAC TCCATCATCC ATGACCTCAA AGTCCCCAGA TCCCAGCCCC TAAGACCCAA GACCCCATCC TGAAGCCCAA AGCCTTGAGA ATTCAAATCC TCACCTCAAG ACTTGGAGAC CCTGGCCCCA TGACATTGAA AACCATGGAC CTGGCCAGGC GTGGTGGCTC ACGCCTGTAA TCCCAGCACT TFGGGAGGCC GAGGCAAGTG GATCACCTGA GGTCGGGAGT TCAAGACCAG CCAGACCAAC ATGGTGAAAC CCTGTCTCTA CTAAAAATAC AAAATTAGCC AGGCGTGGTG GTGCATGCCT GTAATCCCAG CTACTTGGGA GGCTGAGGCA GGAGAATCGC TTGAACCTGG GAGGCGGAGG TTGCAGTGAG CCGAGATCGC ACCATrACAC TCCAGCCTGG GCAACAAGAG CAAAACTCCC TCTCTCTCAA AAAAAAAAAA AAAAAAAAAA AAGAAGGAAA AGAAAACCAT GGACCTCCAG ACCCTGAGAC CCCAGGCCCC AGCCCTGAGA TCCTGACATC TTAAAGATCC CAGGCCCTAA GATACAAGAC CTTGACCCAA AGCCAGCCTT GGGACCCTGG CTGTACAAAC CCAAGACCTC CAGGACCTAG ACCCCGAGCC CTGAGGCCCT ATGTCTCACT CCCAACATCG AAAACCCTGA CACCTCAGAT CCTGAGCCTG CGCCTGTACG ACTCCAAGAC CCTCACTTCC AAAGCCAGGC CCAAAGCCCT GAGACCAGAA GACTCAAAC CCTGGTTCTT GGGCCTAACT CCAAAGACCC TGGATCTCAA ATrCCAACTr CTAGCTCTGA GACTCCAGCC CTCACCCATG AGTTCCTGAA CTTGAACCCA GAGACCCCAT CTCTAAGACT TCAGCCTTGA GATCCAGGGC CTGACCCTAG ACTCGAGCCC ACAGACCTCA GATACTGTCT GTAAAACCCC AGCTCTGGTG GGGAGCAGTG GCTCACTCCT GTAATCCCAA GGCAGGGGAG GCCAAGGCAG AAGGACCTCT TGAGGCCATG AGTTTGAGAC AGCCTGGGCA GCATAGCAAG ACTCTGTTTC TTAATrATTA TTATTATTAT TA1T1GG AGACAGAGTC TCGCGCTCTG TTGCCCAGGC TAGAGTGCAA TGGTGCCATT TCGGCTTGCT GGAACCTCCG CCTCCTGGGC TCAAGCGATT CTCCTGCCTC AGCCTCCTGA GTAGCTGGGA CTTCAGGTGC ACACTGCCAC ACCCGGATAA T11Ti-GTA TTTAGTAGA CACAGGGTF CACCGTGTTG CCCAGGCTGG TCACAAACTC CTGAGCTCAG GCCATCCGCC CGCCTCGGCC TCCCAAAGCG CTGGGATAAC AGGCGTGACG CCGCGCCTGG CTTCTTAATT GTTCTAACAG CAGCGACAAC AACAAAAACC CAGCTCTGAG ATTCCAGCCC CGGCGACTCT AACAGTCCCA GGCCCGATCC CTCACCTAGA ACCGAGATGC CAGCCCTGAC TCCACAGACT TCACCCCCAA CCCCCACACT CAGCTCTGGA AGCCCGTCCT GACTCCAGCC TCCATTTTCG GAACCCCACA GCCTGAAGAG CTCCCGGCCT AAACACTTCA CCCCACGCGC CACAGTCCCC CTGTGAATAT GCAGCCCCGA TTCAGCTGCA GCTCCACAGC ACCCCTGCCC TGCACCCCCG CTGCACCCCC TACCTGTGAC TCACCTCTCT CCTCTCCCCA CAGATGTCCC GCCTGGCCCT GCCCCAGCCA CCCCCGGACC CGCCGGCGCC CCCGCTGGCG CCCCCCTCCT CAGCCTGGGG GGGCATCAGG GCCGCCCACG CCATCCTGGG GGGGCTGCAC CTGACACTTG ACTGGGCCGT GAGGGGACTG CTGCTGCTGA AGACTCGGCT GTGACCCGGG GCCCAAAGCC ACCACCGTCC TTCCAAAGCC AGATCTTATr TATTTATTTA TTTCAGTACT GGGGGCGAAA CAGCCAGGTG ATCCCCCCGC CATTATCTCC CCCTAGTTAG AGACAGTCCT TCCGTGAGGC CTGGGGGGCA TCTGTGCCTT ATTTATACTT ATTTATT7CA GGAGCAGGGG TGGGAGGCAG GTGGACTCCT GGGTCCCCGA GGAGGAGGGG ACTGGGGTCC CGGATTCTTG GGTCTCCAAG AAGTCTGTCC ACAGACTTCT GCCCTGGCTC TTCCCCATCT AGGCCTGGGC AGGAACATAT ATTATTATT TAAGCAATTA CTITTCATGT TGGGGTGGGG ACGGAGGGGA AAGGGAAGCC TGGGITiTTG TACAAAAATG TGAGAAACCT TTGTGAGACA GAGAACAGGG AATTAAATGT GTCATACATA TCCACTTGAG GGCGATMTGT CTGAGAGCTG GGGCTGGATG CTTGGGTAAC TGGGGCAGGG CAGGTGGAGG GGAGACCTCC ATTCAGGTGG AGGTCCCGAG TGGGCGGGGC AGCGACTGGG AGATGGGTCG GTCACCCAGA CAGCTCTGTG GAGGCAGGGT CTGAGCCTTG CCTGGGGCCC CGCACTGCAT AGGGCCGT GGTTGTFFT TGAGATGGAG TCTCGCTCTG TTGCCTAGGC TGGAGTGCAG TGAGGCAATC TAAGGTCACT GCAACCTCCA CCTCCCGGGT TCAAGCAATT CTCCTGCCTC AGCCTCCCGA TTAGCTGGGA TCACAGGTGT GCACCACCAT GCCCAGCTAA TTATrATT CTITTGTATT TTAGTAGAG ACAGGGTTTC ACCATGTTGG CCAGGCTGGT TFCGAACTCC TGACCTCAGG TGATCCTCCT GCCTCGGCCT CCCAAAGTGC TGGGATTACA GGTGTGAGCC ACCACACCTG ACCCATAGGT CTTCAATAAA TATTAATGG AAGGTrCCAC AAGTCACCCT GTGATCAACA GTACCCGTAT GGGACAAAGC TGCAAGGTCA AGATGGTTCA TTATGGCTGT GTTCACCATA GCAAACTGGA AACAATCTAG ATATCCAACA GTGAGGGTrA AGCAACATGG TGCATCTGTG GATAGAACGC CACCCAGCCG CCCGGAGCAG GGACTGTCAT TCAGGGAGGC TAAGGAGAGA GGCTTGCTTG GGATATAGAA AGATATCCTG ACATrGGCCA GGCATGGTGG CTCACGCCTG TAATCCTGGC ACTTGGGAG GACGAAGCGA GTGGATCACT GAAGTCCAAG AGTT7GAGAC CGGCCTGCGA GACATGGCAA AACCCTGTCT CAAAAAAGAA AGAATGATGT CCTGACATGA AACAGCAGGC TACAAAACCA CTGCATGCTG TGATCCCAAT TTTGTGTT TCTTTCTATA TATGGATTAA AACAAAAATC CTAAAGGGAA ATACGCCAAA ATGTTGACAA TGACTGTCTC CAGGTCAAAG GAGAGAGGTG GGATTGTGGG TGACTTTTAA TGTGTATGAT TGTCTGTATT TTACAGAATT TCTGCCATGA CTGTGTATIT TGCATGACAC AITTTAAAAA TAATAAACAC TATTTAGA ATAACAGAAT ATCAGCCTCC TCCTCTCCAA WO 00/09525 PCT/US99/17712 EPI-109 201 AAATAAGCCC TCAGGAGGGG ACAAAGflGA CCGCTGATTG AGCCTGTCAG GGCTGTGCAC-3' (FRAG. NO:_)(SEQ. ID NO:2523) 5'-GCTCAGGGCA CATGCCTCCC CTCCCCAGGC CGCGGCCCAG CTGACCCTCG GGGCTCCCCC GGCAGCGGAC AGGGAAGGGT TAAAGGCCCC CGGCTCCCTG CCCCCTGCCC TGGGGAACCC CTGGCCCTGT GGGGACATGA ACTGTGITT7G CCGCCTGGTC CrGGTCGTGC TGAGCCTGTG GCCAGATACA GCTGTCGCCC CTGGGCCACC ACCTGGCCCC CCTCGAG IT CCCCAGACCC TCGGGCCGAG CTGGACAGCA CCGTGCTCCT GACCCGCTCTr CTCCTG3GCGG ACACGCGGCA GCTGGCTGCA CAGCTGAGGG ACAAATrCCC AGCTGACGGG GACCACAACC TGGATTCCCT GCCCACCCTG GCCATGAGTG CGGGGGCACT GGGAGC7CTA CAGCTCCCAG GTGTGCTGAC AAGGCTGCGA GCGGACCTAC TGTCCrACCT GCGGCACGTG CAGTGGCTGC GCCGGGCAGG TGGCrCTrCC CTGAAGACCC TGGAGCCCGA GCTGGGCACC CTGCAGGCCC GACTGGACCG GCTGCTGCGC CGGCTGCAGC TCCTGATGTC CCGCCTGGCC CTGCCCCAGC CACCCCCGGA CCCGCCGGCG CCCCCGCTGG CGCCCCCCTC CTCAGCCTGG GGGGGCATCA GGGCCGCCCA CGCCATCCTG GGGGGGCTrGC ACCTGACACT TGACTGGGCC GTGAGGGGAC TGCTGCTGCT GAAGACTCGG CTGTGACCCG GGGCCCAAAG CCACCACCGT CC=CCAAAG CCAGATCTTA MTAT7ATT TA ITCAGTA CTGGGGGCGA AACAGCCAGG TGATCCCCCC GCCAT7ATCT CCCCCTAG'IT AGAGACAGTC CITCCGTGAG GCCTGGGGGA CATCTGTGCC 'ITA'ITATAC TTATI-r CAGGAGCAGG GGTGGGAGGC AGGTGGACTC CTGGGTCCCC GAGGAGGAGG GGACTGGGGT CCCGGATITCT TGGGTCTCCA AGAAGTCTGT CCACAGACTI CTGCCCTGGC TCT-rCCCCAT CTAGGCCTGG GCAGGAACAT ATATTAT17A TI7rAAGCAAT TACTITCAT GTTGGGGTGG GGACGGAGGG GAAAGGGAAG CCTrGGG=1I TGTACAAAAA TGTGAGAAAC CTIGTGAGA CAGAGAACAG GGAATTAAAT GTGTCATACA TATCC-3' (FRAG. NO:_)(SEQ. ID NO:2521) 5'-CAGCTGCGGC ATCCTCTGTC TCAGAGTCTr GGTGTCTCTG TrCCITCCC CTCGGGGTCT CCCTGGGTCT CCCCAAGTCC CTCCTGCTGT CTCCTCCCG CTCTCTGATC TCTGACTCCC AGAACCTCTC CCTCTGTCTC CAGGGCTGCC CCTCTGATCC TCTTGCTC TCTGGTGTGT CTCTCTGGCT GCCTCCATCT CTGTGGATCT CCGTCTCCCT GTCTCTGTCT CAGTCTGTCC 17CACTCTGT GTGTGTGTGT GTCTCTCTCT CTCTCTCTCC T7CC=ICCA CTCCcCTrC CTCCTGCCTC CACCTCTCCA GGCCCCTGTC ITGTCCCTCC GTCCGGCCT7 TCTCTGCCTT TCCGTCCTCC TGCCTCCCCA TCTCTcTCTG CTAGTCCTGT CCAGCCGGAC CCCCACCCAC AGTCGGGCCC CAGCGCT-rGA GCCTGAGTGT CTGCTCCGGC CCGTGGAGGT GGAGGGAGGG GACGCCAATG ACCTCACCAG CCCCTCTCCG ACCACCCCCC C=IICCCTT T7CAACTVm CCAAC=r~C C'=CCGTGCC CrCCTCCGAG CGCGGCGGCG TGAGCCCTGC AAGGCAGCCG CTCCGTCTGA ATGGAAAAGG CAGGCAGGGA GGGTGAGTCA GGATGTGTCA GGCCGGCCCT CCCCTGCCGC CTGCCCCCCG CCCGCCCGCC CCAGGCCCCC TATATAACCC CCCAGGCGTC CACACTCCCT CACTGCCGCG GGCCCTGCTG CTCAGGGCAC ATGCCTCCCC TCCCCAGCCG CGGGCCCAGC TGACCCTCGG GGCTCCCCCG GCAGCGGACA GGGAAGGGfl AAAGGCCCCC GGC7CCCTGC CCCCTGCCCT GGGGAACCCC TGGCCCTGTG GGGACATGAA CTGTAAGT7G GTrCATGGGG AGGGTGGAGG GGACAGGGAG GCAGGGAGGA GAGGGACCCA CGGCGGGGGT GGGAGCAGAC CCCGCTGAGT CGCACAGAGA GGGACCCGGA GACAGGCAGC CGGGGAGGAG AGCAGCITCG GAGACAGGAG GCGGCGGAGG AGATGGGCAG AGAGAGACAC AGACAGGAGC GGATGGAGGC AGCCAATCAG AGGCGCCGCA GGAGGGACGG GCCAGACAGG GCCCGAGAGG AGCGAGACGC GAGACCGAGC AGGGGCAGGG ACGCAGGGAC TGGTGCCGGG AGGGAGGTGA CCCCCATCGA CCCAGGCCCC AGGGAGCCCG CGGGGACCGG GAGACTCCCT GGGATrCCGG CAGAGAGGCT CCGGAGGGAA ACTGAGGCAG GGTCCGCGGA GAGCGGAGCA AGCCAGGGAG TAGCGACCCC AGCCGGGGGG AGGAGAGAGA CrGGGCGCCG GGGGAAAGCG GGGAGAGCCG GGCAGATGCG GCCGACGGAG GCGCGGACAG ACCGACGGCT GGCGGGCCCG GGGGGCGGGC TGGGGGTGTG CGAGGCGCGG GCGGCCGGGG AGCGCTGAT7 GGCTGGCGGG TGGCCGGGTG GGCGGGGCGG CCGGGGTGGG CTGCGGGGAG CGAGCTCCGG ACCCCCGCGC CCCCGGCGCC CCCCGCGCCC CCCGCCGCCA GCTCTCCCGC TCCCGGCGCC CGGCCGGGCC ATGGCTCTGC CCCTCTCCGC CCAGGTGCGC TGCGGCCCGG GCFGCCG CCCACCCGGC GGGCTCCTGG GAGGGCGTCT AAGGGGTCTC CCGTGGGAGA GGTCCGTGTC TCCCGGACTC CGTCCTGGGC FI=GGCTCC ITCCCCTGCT CCCAGCCAGC TCGGGCTCCC GCGGCCCGGG GAGGGGGCAG GTTCTGGCCT GTGCCTCCCC CACCATCCGC GCCCCGGGGC CCAGATTCCG GCGTCCGGGG GCGGACGGGA GACGCCCGGG CCGCGTCTGC TCCGACGGGC GGGGCAGCCA GAGCCAGGGA GGGAGAGGGA AGCCCGCCTG GCCCTGCGAC CTGCCCGCGG GCGTTCCACC CTGGGACTTA AGACCTCCAG CTCCATCCTC CCTAAGGCCG GGAGTCCAGG CCCCAGACCC TCCTCCCCGA GACCCAGGAG TCCAGACCCC AGGCCT7CCT CCCTCAGACC TAGGAGTCCA GGCCCCCAGC CTCI'CCTCCC TCAGACCCAG GAGGAGTCCA GACCCCAGTr CCTCC7CCCT CAGACCCGGG AGTCCAGCCC AGGCCCTCCT CTCTCAGACC CGGAGTCCAG CCTGAGCTCT CTGCCTTFATC CTGCCCCCAG GTGTT7GCCG CCTGGTCCTG GTCGTGCTGA GCCTGTGGCC AGATACAGCT GTCGCCCCTG GGCCACCACC TGGCCCCCCTr CGAGMfCCC CAGACCCTCG GGCCGAGCTG GACAGCACCG TGCTCCTGAC CCGCTCTCrC CTGGCGGACA CGCGGCAGCT GGCTGCACAG CTGGTAGGAG AGACTGGGCT GGGGCCAGCA CAGGAGTGAG AGGCAGAGAG GAACGGAGAG GAGTCTGCGG GCAGCCA=T GGAGGGGT7C TGGGCTCTCA GGTGGCAGAG TGAGGGAGGG GAAGAGTTGG GGGCCTGGCG TGGGGGATGG AGGGAGCCCC GAGGCTGGGC AGGGGCCACC TCACAGCIT ITTCCCT7GCC AGAGGGACAA AT7CCCAGCT GACGGGGACC ACAACCTGGA 7rCCCTGCCC ACCCTGGCCA TGAGTGCAGG GGCACTGGGA GCTCTACAGG TAAGGGCAAG GGAGTGGGCT GGGGACAAGG TGGGAGGCAG GCAGTGAAGG GGGCGGGGAG GATGAGGGGC ACTGGTCGGG TGT7CTCTGA TGTCCCGGCT CTATCCCCAG CTCCCAGGTG TGCTGACAAG GCTGCGAGCG GACCTACTGT CCTACCTGCG GCACGTGCAG TGGCTGCGCC GGGCAGGTGG cTCTCCCTG AAGACCVITGG AGCCCGAGCT GGGCACCCTG CAGGCCCGAC TGGACCGGCT GCTGCGCCGG CTGCAGCTCC TGGTATGTCC TGGCCCCAAG ACCTGACACC CCAGACCCCC ACCCCTGGCC CCAAAATCCT GTGGCCTGAG TCCTrGAAGC C7GAGACCCC AGACCCGAGT GCAACAGCCC CGCTCTGAGA CCCTGACACC CTAACAGCCC GCTCTGAGAC CCTGACACCG TAACAGCCCC GCTCTrGAGAC CCrGACCCTA ACAGTCCTGC TCTGAGACCC TGACCCTGCA GTCCCAAGAT CCTGTGGCCC TGAGACCCTG AGGCCCTAGA CCCCCAAATC CTrGCCCAGAA A=TCAAA17 CTCACCCAAG ACCCTGAGAC TCCATCATCC ATGACCTCAA AGTCCCCAGA TCCCAGCCCC TAAGACCCAA GACCCCATCC TGAAGCCCAA AGCCTGAGA AflCAAATCC TCACCTCAAG ACTTGGAGAC CCTGGCCCCA TGACATrGAA AACCATGGAC CTGGCCAGGC GTGGTGGCTC ACGCCTGTAA TCCCAGCACT 'FrGGGAGGCC GAGGCAAGTG GATCACCTGA GGTCGGGAGT TCAAGACCAG CCAGACCAAC ATGGTGAAAC CCTGTCTCTA CTAAAAATAC AAAATrAGCC AGGCGTGGTG GTGCATGCCT GTAATCCCAG CrACTrGGGA GGCTGAGGCA GGAGAATCGC TT~GAACCTGG GAGGCGGAGG rrGCAGTGAG CCGAGATCGC ACCATTACAC TCCAGCCTGG GCAACAAGAG CAAAACTCCC TCTCTCTCAA AAAAAAAAAA AAAAAAAAAA AAGAAGGAAA AGAAAACCAT GGACCTCCAG ACCCTGAGAC CCCAGGCCCC AGCCCTGAGA TCCTGACATC TTFAAAGATCC CAGGCCCTAA GATACAAGAC C'ITGACCCAA AGCCAGCCT7 GGGACCCTGG CTGTACAAAC CCAAGACCTC CAGGACCTAG ACCCCGAGCC CTGAGGCCCT ATGTCTCACT CCCAACATCG AAAACCCTGA WO 00/09525 PCT/US99/17712 EPI-109 202 CACCTCAGAT CCTGAGCCTG CGCCTGTACG ACTCCAAGAC CCTCACTTCC AAAGCCAGGC CCAAAGCCCT GAGACCAGAA GACTTCAAAC CCTGGT7TCTT GGGCCTAACT CCAAAGACCC TGGATCTCAA ATTCCAACTr CTAGCTCTGA GACTCCAGCC CTCACCCATG AGTrCCTGAA CTTGAACCCA GAGACCCCAT CTCTAAGACT TCAGCCTrGA GATCCAGGGC CTGACCCTAG ACTCGAGCCC ACAGACCTCA GATACTGTCT GTAAAACCCC AGCTCTGGTG GGGAGCAGTG GCTCACTCCT GTAATCCCAA GGCAGGGGAG GCCAAGGCAG AAGGACCTCT TGAGGCCATG AGTTGAGAC AGCCTGGGCA GCATAGCAAG ACTCTGTTTC TrAATTATrA TrATrATTAT TATITFGG AGACAGAGTC TCGCGCTCTG TTGCCCAGGC TAGAGTGCAA TGGTGCCATT TCGGCTrGCT GGAACCTCCG CCTCCTGGGC TCAAGCGATT CTCCTGCCTC AGCCTCCTGA GTAGCTGGGA CTTCAGGTGC ACACTGCCAC ACCCGGATAA ITITI rGTA TTTAGTAGA CACAGGGTTT CACCGTGTTG CCCAGGCTGG TCACAAACTC CTGAGCTCAG GCCATCCGCC CGCCTCGGCC TCCCAAAGCG CTGGGATAAC AGGCGTGACG CCGCGCCTGG CTTCTTAATT GTTCTAACAG CAGCGACAAC AACAAAAACC CAGCTCTGAG ATTCCAGCCC CGGCGACTCT AACAGTCCCA GGCCCGATCC CTCACCTAGA ACCGAGATGC CAGCCCTGAC TCCACAGACT TCACCCCCAA CCCCCACACT CAGCTCTGGA AGCCCGTCCT GACTCCAGCC TCCATITTCG GAACCCCACA GCCTGAAGAG CTCCCGGCCT AAACACTTCA CCCCACGCGC CACAGTCCCC CTGTGAATAT GCAGCCCCGA TrCAGCTGCA GCTCCACAGC ACCCCTGCCC TGCACCCCCG CTGCACCCCC TACCTGTGAC TCACCTCTCT CCTCTCCCCA CAGATGTCCC GCCTGGCCCT GCCCCAGCCA CCCCCGGACC CGCCGGCGCC CCCGCTGGCG CCCCCCTCCT CAGCCTGGGG GGGCATCAGG GCCGCCCACG CCATCCTGGG GGGGCTGCAC CTGACACTTG ACTGGGCCGT GAGGGGACTG CTGCTGCTGA AGACTCGGCT GTGACCCGGG GCCCAAAGCC ACCACCGTCC TTCCAAAGCC AGATCTTATT TATTTATTTA TTTCAGTACT GGGGGCGAAA CAGCCAGGTG ATCCCCCCGC CATTATCTCC CCCTAGTTAG AGACAGTCCT TCCGTGAGGC CTGGGGGGCA TCTGTGCCTT A'TTATACTT ATTATTTCA GGAGCAGGGG TGGGAGGCAG GTGGACTCCT GGGTCCCCGA GGAGGAGGGG ACTGGGGTCC CGGATTCTTG GGTCTCCAAG AAGTCTGTCC ACAGACTTCT GCCCTGGCTC TTCCCCATCT AGGCCTGGGC AGGAACATAT ATTATTTATT TAAGCAATTA CTITCATGT TGGGGTGGGG ACGGAGGGGA AAGGGAAGCC TGGGMITIG TACAAAAATG TGAGAAACCT TTGTGAGACA GAGAACAGGG AATTAAATGT GTCATACATA TCCACTTGAG GGCGATTGT CTGAGAGCTG GGGCTGGATG CTTGGGTAAC TGGGGCAGGG CAGGTGGAGG GGAGACCTCC ATTCAGGTGG AGGTCCCGAG TGGGCGGGGC AGCGACTGGG AGATGGGTCG GTCACCCAGA CAGCTCTGTG GAGGCAGGGT CTGAGCCTTG CCTGGGGCCC CGCACTGCAT AGGGCCGTT GTTGTFi' TGAGATGGAG TCTCGCTCTG TTGCCTAGGC TGGAGTGCAG TGAGGCAATC TAAGGTCACT GCAACCTCCA CCTCCCGGGT TCAAGCAATT CTCCTGCCTC AGCCTCCCGA TTAGCTGGGA TCACAGGTGT GCACCACCAT GCCCAGCTAA TTATTTATT CI1TGTATr TTTAGTAGAG ACAGGGTC ACCATGTrGG CCAGGCTGGT TTCGAACTCC TGACCTCAGG TGATCCTCCT GCCTCGGCCT CCCAAAGTGC TGGGATTACA GGTGTGAGCC ACCACACCTG ACCCATAGGT CTTCAATAAA TATTTAATGG AAGGTTCCAC AAGTCACCCT GTGATCAACA GTACCCGTAT GGGACAAAGC TGCAAGGTCA AGATGGTTCA TTATGGCTGT GTTCACCATA GCAAACTGGA AACAATCTAG ATATCCAACA GTGAGGGTTA AGCAACATGG TGCATCTGTG GATAGAACGC CACCCAGCCG CCCGGAGCAG GGACTGTCAT TCAGGGAGGC TAAGGAGAGA GGCTTGCTTG GGATATAGAA AGATATCCTG ACATTGGCCA GGCATGGTGG CTCACGCCTG TAATCCTGGC ACTITGGGAG GACGAAGCGA GTGGATCACT GAAGTCCAAG AG'TTGAGAC CGGCCTGCGA GACATGGCAA AACCCTGTCT CAAAAAAGAA AGAATGATGT CCTGACATGA AACAGCAGGC TACAAAACCA CTGCATGCTG TGATCCCAAT MTTGTGTTT TCTCTATA TATGGATTAA AACAAAAATC CTAAAGGGAA ATACGCCAAA ATGTTGACAA TGACTGTCTC CAGGTCAAAG GAGAGAGGTG GGATTGTGGG TGACTITTAA TGTGTATGAT TGTCTGTAT T17ACAGAATT TCTGCCATGA CTGTGTAT TGCATGACAC ATIAAAAA TAATAAACAC TAT1111AGA ATAACAGAAT ATCAGCCTCC TCCTCTCCAA AAATAAGCCC TCAGGAGGGG ACAAAGTTGA CCGCTGATTG AGCCTGTCAG GGCTGTGCAC- 3' (FRAG. NO: ) (SEQ. ID NO:2522) Human GM-CSF Nucleic Acid and Antisense Oligonucleotide Fragments 5'-CTTGBGCBGG BBGCTCTGGG GCBGGGBGCT GGCBGGGCCC BGGGGGGTGG CTTCCTGCBC TGTCCBGBGT GCBCTGTGCC BCBGCBGCBG CTGCBGGGCC BTCBGCTICB TGGGGCTCTG GGTGGCBGGT CCBGCCBTGG GTCTGGGTGG GGCTGGGCTG CBGGCTCCGG GCGGTCCBGCCBTGGGTCTG GGGGCTGGG CTGCBGGCTC CGGGCGGGCG GGTGCGGGCT GCGTGCTGGG GGCTGCCCCG CAGGCCCTGC GGTCCBGCCB TGGGTCTGGG GGCTGGGCTG CBGGCTCCGG GCGGGCGGGT GCGGGCTGCG TGCTGGGGGC TGCCCCGCAG GCCCTGC-3' (FRAG. NO:1847) (SEQ. ID NO: 1858) 5'-GBGCBGG BBG-3' (FRAG. NO:1848) (SEQ. ID NO: 1859) 5'-GCCBCBGCBGCBGC-3' (FRAG. NO:1849) (SEQ. ID NO: 1860) 5'-GGG TGC GGG C-3' (FRAG. NO:1850) (SEQ. ID NO: 1861) 5'-GGT CCB GCC BTG GGT CTG GG-3' (FRAG. NO:1300)(SEQ. ID NO:1310) 5-GGC TGG GCT GCB GGC TCC GG-3' (FRAG. NO:1301)(SEQ. ID NO:1311) 5'-GCG GGC GGG TGC GGG CTG CGT GCT GGG-3' (FRAG. NO:1302)(SEQ. ID NO:1312) 5'-GGC TGC CCC GCA GGC CCT GC-3' (FRAG. NO:1303)(SEQ. ID NO:1313) 5'-CTTGBGCBGG BBGCTCTGGG GCBGGGBGCT GGCBGGGCCC BGGGGGGTGG CTTCCTGCBC TGTCCBGBGT GCBCTGTGCC BCBGCBGCBG CTGCBGGGCC BTCBGCTTCB TGGGGCTCTG GGTGGCBGGT CCBGCCBTGG GTCTGGGTGG GGCTGGGCTG CBGGCTCCGG GC-3' (FRAG. NO:1851) (SEQ. ID NO: 1862) Human Tumor Necrosis Factor " Antisense Oligonucleotide Fragments 5'-GCBCCGCCTG GBGCCCTGGG GCCCCCCTGT CTTCTTGGGG BGCGCCTCCT CGGCCBGCTC CBCGTCCCGG BTCBTGCT CBGTGCTCBT GGTGTCCTTT CCBGGGGBGB GBGGGGCTGG TCCTCTGCTG TCCTTGCTGG TGCTCBTGGT GTCCTTCCG CCCTGGGGCC CCCCTGTCTT CTTGGGGCCT CTTCCCTCTG GGGGCCGTCT CTCTCCCTCT CTTGCGTCTC TCTCTCTC TCTCTCTCTT CCCCTCCC GCTCITCTG TCTCGGTGTC TGGTCTC TCTCCGCTGG CTGCCTGTCT GGCCTGCGCT CTTGGCCTGT GCTGTTCCTC CTCCGGTTCC TGTCCTCTCT GTCTGTCGCC CCCTCTGGGG TCTCCCTCTG GGTGGTGGTC TTGTTGCTTG GGCTGGGCTC CGTGTCTCCB GTGCTCBTGG TGTCCGCTGB GGGBGCGTCT GCTGGCGCTG GTCCTCTGCTGTC CTTGCTGGTG CTCBTGGTGT CCTTCCGCC CTGGGGCCCC CCTGTCTTCT TGGGGCCTCT TCCCTCTGGG GGCCGTCTC TCTCCCTCTC TTGCGTCTCT CTCTCTCT CTCTCTCTTC CCCTTTCCCG CTCTTCTGT CTCGGTGTCT GGTTTCTCT CTCCGCTGGC TGCCTGTCTG GCCTGCGCTC TTGGCCTGTG CTGTTCCTCC TCCGGTTCCT GTCCTCTCTG TCTGTCGCCC CCTCTGGGGT CTCCCTCTGG CGTGGTGGTC TTGTTGCTTG GGCTGGGCTC CGTGTCTCCB GTGCTCBTGG TGTCCGCTGB GGGBGCGTCT GCTGGC-3' (FRAG. NO:1852) (SEQ. ID NO:1863) 5'-GGGGCCCCCC-3' (FRAG. NO:1853) (SEQ. ID NO:1864) WO 00/09525 PCT/US99/17712 EPI-109 203 5'- GGG GGC CG TCT-3' (FRAG. NO:1854) (SEQ. ID NO:1865) 5'-CCBGGGGBGB GBGGGGCTGG-3' (FRAG. NO:1855) (SEQ. ID NO:1866) 5' GCBCCGCCTGGBGCCCTGGGGCCCCCCTGTCTTCTGGGGBGCGCCTCCTCGGCCBGCTCCBCGTCCCGGBTCBTGC'TTCBGTGC TCBTGGTGTCCTTTCCBGGGGBGBGBGGG-3' (FRAG. NO:1304) (SEQ. ID NO:1314) 5'-GCT GGT CCT CTG CTG TCC TTG CTG GTG CTC BTG GTG TCC TTT CC GCC CTG GGG CCC CCC TGT C7 CTT GGG G CCT CTT CCC TCT GGG GGC CG TCT CTC TCC CTC TCT TGC GTC TCT C TCT TTC TCT CTC TCT CT7 CCC C TTT CCC GCT CTr TCT GTC TC GGT GTC TGG T TCT CTC TCC GCT GGC TGC CTG TCT GGC CTG CGC TCT T GGC CTG TGC TGT TCC TCC TCC GGT TCC TGT CCT CTC TGT CTG TC GCC CCC TCT GGG GTC TCC CTC TGG C GTG GTG GTC TTG TTG CTT GGG CTG GGC TCC GTG TCT C CBG TGC TCB TGG TGT CC-3' (FRAG. NO:1305) (SEQ. ID NO:1315) 5'-GCT GBG GGB GCG TCT GCT GGC GCT GGT CCT CTG CTG TCC TTG CTG GTG CTC BTG GTG TCC TTT CC GCC CTG GGG CCC CCC TGT C= CTT GGG G CCT CTT CCC TCT GGG GGC CG TCT CTC TCC CTC TCT TGC GTC TCT C TCT TTC TCT CTC TCT CTT CCC C T17 CCC GCT CTT TCT GTC TC GGT GTC TGG TTT TCT CTC TCC GCT GGC TGC CTG TCT GGC CTG CGC TCT T GGC CTG TGC TGT TCC TCC TCC GGT TCC TGT CCT CTC TGT CTG TC GCC CCC TCT GGG GTC TCC CTC TGG C GTG GTG GTC TTG TTG CTT GGG CTG GGC TCC GTG TCT C CBG TGC TCB TGG TGT CC GCT GBG GGB GCG TCT GC GGC-3' (FRAG. NO:1306) (SEQ. ID NO:1316) 5-GCT GGT CCT CTG CTG TCC TTG CTG-3' (FRAG. NO:1655) (SEQ. ID NO:1665) 5'-GTG CTC BTG GTG TCC TT CC-3' (FRAG. NO:1656)(SEQ. ID NO:1666) 5'-GCC CTG GGG CCC CCC TGT CTT CTT GGG G-3' (FRAG. NO:1657)(SEQ. ID NO:1667) 5'-CCT C17 CCC TCT GGG GGC CG-3' (FRAG. NO:1658)(SEQ. ID NO:1668) 5'-TCT CTC TCC CTC TCT TGC GTC TCT C-3' (FRAG. NO:1659)(SEQ. ID NO:1669) 5'-TCT TTC TCT CTC TCT C7 CCC C-3' (FRAG. NO:1660)(SEQ. ID NO:1670) 5'-TT CCC GCT CTT TCT GTC TC-3' (FRAG. NO:1661)(SEQ. ID NO:1671) 5'-GGT GTC TGG TTT TCT CTC TCC-3' (FRAG. NO:1662)(SEQ. ID NO:1672) 5'-GCT GGC TGC CTG TCT GGC CTG CGC TCT T-3' (FRAG. NO:1663)(SEQ. ID NO:1673) 5'-GGC CTG TGC TGT TCC TCC-3' (FRAG. NO:1664)(SEQ. ID NO:1673) 5'-TCC GGT TCCTOTGCT CTC TGT CT TC-3' (FRAG. NO:1665)(SEQ. ID NO:1675) 5'-GCC CCC TCT GGG GTC TCC CTC TGG C-3' (FRAG. NO:1666)(SEQ. ID NO:1676) 5'-GTG GTG GTC TTG TTG CTT-3' (FRAG. NO:1667)(SEQ. ID NO:1677) 5'-GGG CT GGC TCC GTG TCT C-3' (FRAG. NO:1668)(SEQ. ID NO:1678) 5'-CBG TGC TCB TGG TGT CC-3' (FRAG. NO:1669)(SEQ. ID NO:1679) 5'-GCT GBG GGB GCG TCT GCT GGC-3' (FRAG. NO:1670)(SEQ. ID NO:1680) Human Leukotriene C4 Svnthase Nucleic Acids and Antisense Oligonucleotide Fragments 5'-CTCGGTBGBC GCGCTCGBBC TCGGGTGGGC CGGTGGTGBG CGGCGGCGBCB CGCGGBBGGC CCTGCGCGCC GBGBTCBCCTG CBGGGBGBBG TBGGCTTGCB GCBGGBCTCC CBGGBGGGTG BCBGCBGCCB GTBGBGCTBC CTCGTCCTTC BTGGTBCCGT CGGTGTGGTG GCBCGGGCTG TGTGTGBBGG CGBGCTGGGC CCCGTCTGCT GCTCCTCGTG CCGCCTCGTC CTTCA TGG TA CCGTCGGTGT GGTGGCCTCG GGTGGGCCGG TGGTGGGGCG CGCGCGCTCG CGTGGCTCCG GCTCTTCTTT CCCGGCTCCGT CGGCCCGGGG GCCTTGGTCT CCCTCGTCCT TCBTGGTBCC G-3' (FRAG. NO:1856) (SEQ ID NO: 1867) 5'-GCB GCBGGBC-3' (FRAG. NO:1857) (SEQ ID NO: 1868) 5'-CCCGGCTCCG-3' (FRAG. NO:1858) (SEQ ID NO: 1869) 5-CGGCCCGGGG GCC-3' (FRAG. NO:1859) (SEQ ID NO: 1870) 5'-CB CGCGG-3' (FRAG. NO:1860) (SEQ ID NO: 1871) 5'-GCC CCG TCT GCT GCT CCT CGT GCC G-3' (FRAG. NO:1307)(SEQ. ID NO:1317) 5'-CCT CGT CCT TCA TGG TAC CGT CGG TGT GGT GGC-3' (FRAG. NO:1308)(SEQ. ID NO:1318) 5'-CTC GGG TGG GCC GGT GGT G-3' (FRAG. NO:1309)(SEQ. ID NO:1319) 5'-GGG CGC GCG CGC TCG CGT-3' (FRAG. NO:1310)(SEQ. ID NO:1320) 5'-GGC TCC GGC TCT TCT TTC CCG GCT CCG TCG GCC CGG GGG CCT TGG TCT C-3' (FRAG. NO:1311) (SEQ. ID NO:1321) 5'-CCT CGT CCT TCB TGG TBC CG-3' (FRAG. NO:1312)(SEQ. ID NO:1322) 5'-CTCGGTBGBC GCGCTCGBBC TCGGGTGGGC CGGTGGTGBG CGGCGGCGBCB CGCGGBBGGC CCTGCGCGCC GBGBTCBCCTG CBGGGBGBBG TBGGCTTGCB GCBGGBCTCC CBGGBGGGTG BCBGCBGCCB GTBGBGCTBC CTCGTCCT1TC BTGGTBCCGT CGGTGTGGTG GCBCGGGCTG TGTGTGBBGG CGBGCTGG-3' (FRAG. NO:1861) (SEQ ID NO: 1872) Human Endothelin-1 Nucleic Acids and Antisense Oligonucleotide Fragments 5'-BCCGGCGGBG CCGCCBGGGT GGBCTGGGBG TGGGITTCTC CCCGCCGTTC TCBCCCBCCG CGCTGBGCTC BGCGCCTBBG BCTGCTGTTT CTGGBGCTCC TTGGCBBGCC BCBBBCBGCB GBGBGBBBBT CBTGBGCBBB TBBTCCBTTC TGBBBBBBBG GGBTCBBBBB CCTCCCGTTC CCCGTTCGCC TGGCGCGCGC TGCGGGTTCC TCGTGGGTTT CTCCCCGCCG TT1CTCCGGTC TGTTGCCTTT GTGGGCT7CT TGTCTilT7G GCTGTTCTIT TCCTGC1TGG CGTCrillCC TT7CTTT1GTG CTCGGTTGTG GGTCCGCTGG TCCTTTGCCC TGTGTGTTTC TGCTGCCCGT TCGCCTGGCG CGCGCTGCGG GTTCCTCGTG GGTTTCTCCC CGCCGT7CTC CGGTCTGTTG CCTTTGTGGG CTTCTTGTCT TTTTGGCTGT TCTTTTCCTG CTTGGCGTCT TT7CCTTTCT 7GTGCTCGG TTGTGGGTCC GCTGGTCCTT TGCCCTGTGT GT7TCTGCTG-3' (FRAG. NO:1862) (SEQ. ID NO:1873) 5'-CCGGCGGBG CCGCCBGGGT GGBC-3' (FRAG. NO:1863) (SEQ. ID NO:1874) 5'-CCGCCBGGG-3' (FRAG. NO:1864) (SEQ. ID NO:1875) 5'-GGCGCGCGC-3' (FRAG. NO:1865) (SEQ. ID NO:1876) 5'-GTGGGTCCGC-3' (FRAG. NO:1866) (SEQ. ID NO:1877) 5'-CCCGTTCGCCTGGCGC-3' (FRAG. NO:1313)(SEQ. ID NO:1323) 5'-GCGCTGCGGGTTrCCTC-3' (FRAG. NO:1314)(SEQ. ID NO:1324) 5'-GTGGGT7CTCCCCGCCGTTCTC-3' (FRAG. NO:1315)(SEQ. ID NO:1325) 5'-CGGTCTGTTGCCTTTGTGGG -3' (FRAG. NO:1316)(SEQ. ID NO:1326) WO 00/09525 PCT/US99/177-12 EPI-109 204 5'-CTTCTTGTCTFGGCT-3' (FRAG. NO:1317)(SEQ. ID NO:1327) 5'-GT'rCrTCCTGCTrGGC-3' (FRAG. NO:1318)(SEQ. ID NO:1328) 5'-GTCTI-CCTTCTT-3' (FRAG. NO:1319)(SEQ. ID NO:1329) 5'-TGTGCTCGGTTGTGGGTC-3' (FRAG. NO:1320)(SEQ. ID NO:1330) 5'-CGCTGGTCCTTTGCC-3' (FRAG. NO:1321)(SEQ. ID NO:1331) 5'-CTGTGTGTTCTGCTG-3' (FRAG. NO:1322)(SEQ. ID NO:1332) 5'-CCCGTrCGCCTGGCGC-3' FRAGG. NO:1323)(SEQ. ID NO:1333) 5'-GCGCTGCGGGTrCCTC-3' (FRAG. NO:1324)(SEQ. ID NO:1334) 5'-GTGGGTr'TCTCCCCGCCGTrCTC-3' (FRAG. NO:1325(SEQ. ID NO:1335) 5'-CGGTCTGT'GCCTTTGTGGG-3' (FRAG. NO:1326)(SEQ. ID NO:1336) 5'-CT'CTTGTCIT-TGGCT-3' (FRAG. NO:1327)(SEQ. ID NO:1337) 5'-GTrCTTTCCTGCTTGGC-3' (FRAG. NO:1328)(SEQ. ID NO:1338) 5'-GTCT1TrCCTTTCTr-3' (FRAG. NO:1329)(SEQ. ID NO:1339) 5'-TGTGCTCGGTTGTGGGTC-3' (FRAG. NO:1330)(SEQ. ID NO:1340) 5'-CGCTGGTCCTTTGCC-3' FRAGG. NO:1331)(SEQ. ID NO:1341) 5'-CTGTGTGTTrCTGCTG-3' (FRAG. NO:1332)(SEQ. ID NO:1342) Endothelin Receptor ET-B Nucleic Acids and Antisense Oligonucleotide Fragments 5'-GCCCTGTCGG GCGGGAAGCC TCTCTCCTCT CCCCAGATC CGCGACAGGC CGCAGGCAAG AACCAGCGCA ACCAGGGCGC GTCCGCACAG ACTTGGAGGC GGCTGCATGC TGCTACCTGC TCCAGAAGCG TCCGGTGGCC GCCGCGCC CTGTCGGGCG GGBBGCCTCT CTCCTCTCCC CBGBTCCGCG BCBGGCCGCB GGCBBGBBCC BGCGCBBCCB GGGCGCGTCC GCBCBGBCTT GGBGGCGGCT GCBTGCTGCT BCCTGCTCGGGCG GGBBGCCTCCG GTGGCCGCCG CGCGTCCGGT GGCCGCCGCG CCTCTCTCCT CTCCCCGTGG CCCTGTCGGG CGGGTCCTGC CGTCCTGTCT CCTTTCTTT TGCTGTCTTG TCTTCCCGTC TCTGCT-3' (FRAG. NO: 1867) (SEQ. ID NO: 1878) 5'-CGGGCG GGBBGCC-3' (FRAG. NO: 1868) (SEQ. ID NO: 1879) 5'-CGGGCGGG-3' (FRAG. NO: 1869) (SEQ. ID NO: 1880) 5'-CCGCBCBGBC-3' (FRAG. NO: 1870) (SEQ. ID NO: 1881) 5-GCGTCCGGTGGCCGCCGC-3' (FRAG. NO:1333)(SEQ. ID NO:1343) 5'-GCCTCTCTCCTCTCCCC-3' (FRAG. NO:1334)(SEQ. ID NO:1344) 5'-GTGGCCCTGTCGGGCGGG-3' (FRAG. NO:1335)(SEQ. ID NO:1345) 5'-TCCTGCCGTCCTGTCTCCTT-3' (FRAG. NO:1336)(SEQ. ID NO:1346) 5'-TCTITGCTGTCITGT-3' (FRAG. NO:1337)(SEQ. ID NO:1347) 5'-CTCCCGTCTCTGC=TT-3' (FRAG. NO:1338)(SEQ. ID NO:1348) 5'-GCCCTGTCGG GCGGGAAGCC TCTCTCCTCT CCCCAGATC CGCGACAGGC CGCAGGCAAG AACCAGCGCA ACCAGGGCGC GTCCGCACAG ACTTGGAGGC GGCTGCATGC TGCTACCTGC TCCAGAAGCG TCCGGTGGCC GCCGC-3' (FRAG. NO: 1871) (SEQ. ID NO: 1882) 5'-GCCCTGTCGG GCGGGBBGCC TCTCTCCTCT CCCCBGBTCC GCGBCBGGCC GCBGGCBBGB BCCBGCGCB BCCBGGGCGC GTCCGCBCBG BCTrGGBGGC GGCTGCBTGC TGCTBCCTGC TCCBGBBGCG TCCGGTGGCC GCCGC-3' (FRAG. NO: 1872) (SEQ. ID NO: 1883) Endothelin ETA Receptor Nucleic Acids and Antisense Oligonucleotide Fragments 5'-GTCTGTCCTC CCCGTCTCCT CCCACTGCTr CTCCCGGGGG CTTCCCCGGC TTCGGGTGGC CGGTGTCCCG GGCTCCGGCG CGGCGGCGGC TTCGGCTGCG GGTGGGTGGC GCGGGCTGCC GGGTCCGCGC GGCGCCTGGG CCCTTGTGCT GCTFITI'GCT TGTTCCGTrC TGGCTGCTCC GGTCTGTGTT GTGGTTGTT TGITCTTCT TGGGTGTGGG CCTTGCGGTT TTGGCTGTGG GCCCT7TGGG GCCTrGGCTT CTGGCTCGTC TGTCCTCCCC GTCTCCTCCC ACTGCTTCT CCCGGGGGCT TCCCCGGCT CGGGTGGCCG GTGTCCCGGG CTCCGGCGCG GCGGCGGCTT CGGCTGCGGG TGGGTGGCGC GGGCTGCCGG GTCCGCGCGG CGCCTGGGCC CTTGTGCTGC 1TTITGCTTG TTCCGTTCTG GCTGCTCCGG TCTGTGTTGT GGTTGT iG TTTCTTCTTG GGTGTGGGCC TrGCGGTITT GGCTGTGGGC CCTTTGGGGC CTTGGCTrCT GGCTCCAT CCACATGATT GCTTAGATTT GTGCTGTATC TCTCAGGATT ATCACTGATT ACACATCCAA CCAGTGCCAG CCAAAAGGAT GCCCTGAGGC AAAGGGTTTC CATCTTGAGG CAAATITGAG GACBTCCBC BTGBTTGCTT BGB'TTTGTGC TGTBTCTCTC BGGBTTBTCB CTGBTTBCBC BTCCBBCCBG TGCCBGCCBB BBGGBTGCCC TGBGGCBBBG GGTTrCCBTC TTGBGGCBBB TTTGBGGB-3' (FRAG. NO:1873) (SEQ. ID NO: 1884) 5'-GBGGCBBBGGG-3' (FRAG. NO:1874) (SEQ. ID NO: 1885) 5'-GCCBGCCBB BBGGB-3' (FRAG. NO:1875) (SEQ. ID NO: 1886) 5'-CGCCTGGGCC C-3' (FRAG. NO:1876) (SEQ. ID NO: 1887) 5'-GTCTGTCCTCCCCGTCTCCTCCC-3' (FRAG. NO:1339)(SEQ. ID NO:1349) 5'-ACTGCTTCTCCCGGGG-3' (FRAG. NO:1340)(SEQ. ID NO:1350) 5'-GCTCCCCGGCTrC-3' (FRAG. NO:1341)(SEQ. ID NO:1351) 5'-GGGTGGCCGGTGTCCCGGGCTCCGGCGCGGCGGC-3' (FRAG. NO:1342)(SEQ. ID NO:1352) 5'-GGCTTCGGCTGC-3' (FRAG. NO:1343)(SEQ. ID NO:1353) 5'-GGGTGGGTGGCGCGG-3' FRAGG. NO:1344)(SEQ. ID NO:1354) 5'-GCTGCCGGGTCCGCGCGGCGCCTGGGCC-3' (FRAG. NO:1345)(SEQ. ID NO:1355) 5'-CTrGTGCTGCITr-3' (FRAG. NO:1346(SEQ. ID NO:1356) 5'-TGCTTGTTCCGTTC-3' (FRAG. NO:1347)(SEQ. ID NO:1357) 5'-TGGCTGCTCCGGTCTGTGTrGTGGTrGTTG-3' (FRAG. NO:1348)(SEQ. ID NO:1358) 5'-TTrCTrCTTGGGTGTGGG-3' (FRAG. NO:1349)(SEQ. ID NO:1359) 5'-CC~FGCGGT=ITIGG-3' (FRAG. NO:1350)(SEQ. ID NO:1360) 5'-CTGTGGGCCCTG-3' (FRAG. NO:1351)(SEQ. ID NO:1361) 5'-GGGCCT7GGCTTCTGGCTC-3' (FRAG. NO:1352)(SEQ. ID NO:1362) 5'-CATCCACATG ATTGCTrAGA T1TGTGCTGT ATCrCTCAGG ATTATCACTG ATTACACATC CAACCAGTGC CAGCCAAAAG GATGCCCTGA GGCAAAGGGT TFrCCATCTG AGGCAAATTr GAGGA-3' (FRAG. NO:1353)(SEQ. ID NO:1363) WO 00/09525 PCT/US99/17712 EPI-109 205 5'-CBTCCBCBTG BTTGCTTBGB TTGTGCTGT BTCTCTCBGG BTTBTCBCTG BTTBCBCBTC CBBCCBGTGC CBGCCBBBBG GBTGCCCTGB GGCBBBGGGT TTCCBTCTTG BGGCBBBT GBGGB-3' (FRAG. NO:1354)(SEQ. ID NO:1364) Endothelin Receptor A Nucleic Acid and Antisense Oligonucleotide Fra2ments 5'-GCCACCATGG AAACCC'TTG CCTCAGGGCA TCCTITTGGC TGGCACTGGT TGGATGTGTA ATCAGTGATA ATCCTGAGAG ATACAGCACA AATCTAAGCA ATCATGTGGA TGATTTCACC ACTITTCGTG GCACAGAGCT CAGCTTCCTG GTTACCACTC ATCAACCCAC TAATTGGTC CTACCCAGCA ATGGCTCAAT GCACAACTAT TGCCCACAGC AGACTAAAAT TACTTCAGCT TrCAAATACA TTAACACTGT GATATCTTGT ACTATITTCA TCGTGGGAAT GGTGGGGAAT GCAACTCTGC TCAGGATCAT TTACCAGAAC AAATGTATGA GGAATGGCCC CAACGCGCTG ATAGCCAGTC TTGCCCTTGG AGACCTATC TATGTGGTCA TTGATCTCCC TATCAATGTA TGGCTGGGCG CTGGCC'T1 GATCACAATG ACITTGGCGT ATTTCTTGC AAGCTGTTCC CC'IT11GCA GAAGTCCTCG GTGGGGATCA CCGTCCTCAA CCTCTGCGCT CTTAGTGTTG ACAGGTACAG AGCAGTTGCC TCCTGGAGTC GTGTTCAGGG AATTGGGATT CCTGGTAA CTGCCATTGA AATTGCCTCC ATCTGGATCC TGTCCTTTAT CCTGGCCATF CCTGAAGCGA TTGGCTTCGT CATGGTACCC 17GAATATA GGGGTGGACA GCATAAAACC TGTATGCTCA ATGCCACATC AAAATTCATG GAGTTCTACC AAGATGTAAA GGACTGGTGG CTCTTCGGGT TCTATTTCTG TATGCCCTTG GTGTGCACTG CGATCTTCTA CACCCTCATG ACTGGTGAGA TGTTGAACAG AAGGAATGGC AGCTTGAGAA TTGCCCTCAG TGAACATCTT AAGCAGCGTC GAGAAGTGGC AAAAACAGTT TTCTGCTTGG TTGTAAT11 TGCTCTGC TGGTTCCCTC TTCATTAAG CCGTATATTG AAGAAAACTG TGTATAACGA GATGGACAAG AACCGATGTG AATTACTTAG TCTTACTG CTCATGGATT ACATCGGTAT TAACTTGGCA ACCATGAATT CATGTATAAA CCCCATAGCT CTGTATTG TGAGCAAGAA ATTAAAAAT TGTTCCAGT CATGCCTCTG CTGCTGCTGT TACCAGTCCA AAAGTCTGAT GACCTCGGTC CCCATGAACG GAACAAGCAT CCAGTGGAAG AACCACGATC AAAACAACCA CAACACAGAC CGGAGCAGCC ATAAGGACAG CATGAACTGA CCACCCTTAG AAGCACTCCT GAATrCGGGA AAAAGTGAAG GTGTAAAAGC AGCACAAGTG CAATAAGAGA TATTTCCTCA AATTTGCCTC AAGATGGAAA CCCTTGCCT CAGGGCATCC TGGCTGG CACTGGTTGG ATGTGTAATC AGTGATAATC CTGAGAGATA CAGCACAAAT CTAAGCAATC ATGTGGATGA TTTCACCACT TrCGTGGCA CAGAGCTCAG CTTCCTGGTT ACCACTCATC AACCCACTAA TTTGGTCCTA CCCAGCAATG GCTCAATGCA CAACTATTGC CCACAGCAGA CTAAAATTAC TTCAGCTC AAATACATTA ACACTGTGAT ATCTTGTACT ATTCATCG TGGGAATGGT GGGGAATGCA ACTCTGCTCA GGATCATA CCAGAACAAA TGTATGAGGA ATGGCCCCAA CGCGCTGATA GCCAGTCTTG CCCTTGGAGA CCTTATCTAT GTGGTCATTG ATCTCCCTAT CAATGTATTT AAGCTGCTGG CTGGGCGCTG GCCITITGAT CACAATGACT TTGGCGTATT TCTTTGCAAG CTGTTCCCCT TITTGCAGAA GTCCTCGGTG GGGATCACCG TCCTCAACCT CTGCGCTCTr AGTGTTGACA GGTACAGAGC AGTTGCCTCC TGGAGTCGTG TTCAGGGAAT TGGGATCCT TTGGTAACTG CCATTGAAAT TGTCTCCATC TGGATCCTGT CCTATCCT GGCCATTCCT GAAGCGATTG GCTTCGTCAT GGTACCCT GAATATAGGG GTGAACAGCA TAAAACCTGT ATGCTCAATG CCACATCAAA ATTCATGGAG rCTACCAAG ATGTAAAGGA CTGGTGGCTC TTCGGGTTCT ATTTCTGTAT GCCCTrGGTG TGCACTGCGA TCTTCTACAC CCTCATGACT TGTGAGATGT TGAACAGAAG GAATGGCAGC TTGAGAATrG CCCTCAGTGA ACATCTTAAG CAGCGTCGAG AAGTGGCAAA AACAGTITIC TGCTGGTTG TAATITITGC TC=TTGCTGG TTCCCTCTTC ATTTAAGCCG TATATTGAAG AAAACTGTGT ATAACGAGAT GGACAAGAAC CGATGTGAAT TACrTAGI CTTACTGCTC ATGGATTACA TCGGTATTAA CTTGGCAACC ATGAATTCAT GTATAAACCC CATAGCTCTG TATITTGTGA GCAAGAAATT TAAAAATTGT TTCCAGTCAT GCCTCTGCTG CTGCTG7TAC CAGTCCAAAA GTCTGATGAC CTCGGTCCCC ATGAACGGAA CAAGCATCCA GTGGAAGAAC CACGATCAAA ACAACCACAA CACAGACCGG AGCAGCCATA AGGACAGCAT GAACTGACCA CCCTTAGAAG CACTCCTCGG TACTCCCATA ATCCTCTCGG AGAAAAAAAT CACAAGGCAA CTGTGAGTCC GGGAATCTCT TCTCTGATCC TTCTTCCTrA ATTCACTCCC ACACCCAAGA AGAAATGCTT TCCAAAACCG CAAGGGTAGA CTGGTTATC CACCCACAAC ATCTACGAAT CGTACT7CTT TAATTGATCT AATTTACATA TTCTGCGTGT TGTATTCAGC ACTAAAAAAT GGTGGGAGCT GGGGGAGAAT GAAGACTGTT AAATGAAACC AGAAGGATAT TrACTACT TGCATGAAAA TAGAGC=C AAGTACATGG CTAGCTITTA TGGCAGTTCT GGTGAATGIT CAATGGGAAC TGGTCACCAT GAAACTAG AGATTAACGA CAAGATI11C TAC1111r1 AAGTGAT 'TGTCCTC AGCCAAACAC AATATGGGCT CAAGTCACTT TTATTGAAA TGTCATTTGG TGCCAGTATC CCGAATTC GAATTCGGGA AAAAGTGAAG GTGTAAAAGC AGCACAAGTG CAATAAGAGA TATTTCCTCA AATTGCCTC AAGATGGAAA CCCTTTGCCT CAGGGCATCC TTTTGGCTGG CACTGGTTGG ATGTGTAATC AGTGATAATC CTGAGAGATA CAGCACAAAT CTAAGCAATC ATGTGGATGA 'TTCACCACT TTTCGTGGCA CAGAGCTCAG CTTCCTGGTT ACCACTCATC AACCCACTAA TTGGTCCTA CCCAGCAATG GCTCAATGCA CAACTATTGC CCACAGCAGA CTAAAATTAC TTCAGCTTC AAATACATTA ACACTGTGAT ATCTTGTACT ATTTTCATCG TGGGAATGGT GGGGAATGCA ACTCTGCTCA GGATCATTA CCAGAACAAA TGTATGAGGA ATGGCCCCAA CGCGCTGATA GCCAGTCTFG CCCTTGGAGA CCTTATCTAT GTGGTCATTG ATCTCCCTAT CAATGTATT AAGCTGCTGG CTGGGCGCTG GCCITITGAT CACAATGACT TTGGCGTATr TCITTGCAAG CTGTTCCCCT TTGCAGAA GTCCTCGGTG GGGATCACCG TCCTCAACCT CTGCGCTCrT AGTGTTGACA GGTACAGAGC AGTTGCCTCC TGGAGTCGTG TTCAGGGAAT TGGGATTCCT TTGGTAACTG CCATrGAAAT TGTCTCCATC TGGATCCTGT CCTATCCT GGCCATTCCT GAAGCGATTG GCTTCGTCAT GGTACCCTT GAATATAGGG GTGAACAGCA TAAAACCTGT ATGCTCAATG CCACATCAAA ATTCATGGAG TTCTACCAAG ATGTAAAGGA CTGGTGGCTC TrCGGGTTCT ATTTCTGTAT GCCCTTGGTG TGCACTGCGA TCTTCTACAC CCTCATGACT TGTGAGATGT TGAACAGAAG GAATGGCAGC TTGAGAATTG CCCTCAGTGA ACATCTFAAG CAGCGTCGAG AAGTGGCAAA AACAGT=TC TGCTTGGTTG TAATIT1-GC TCFTGCTGG TTCCCTCTrC ATTTAAGCCG TATATTGAAG AAAACTGTGT ATAACGAGAT GGACAAGAAC CGATGTGAAT TACTrAGT CTTACTGCTC ATGGATTACA TCGGTAT7AA CTTGGCAACC ATGAATrCAT GTATAAACCC CATAGCTCTG TAITTGTGA GCAAGAAATT TAAAAATTGT TFCCAGTCAT GCCTCTGCTG CTGCTGTTAC CAGTCCAAAA GTCTGATGAC CTCGGTCCCC ATGAACGGAA CAAGCATCCA GTGGAAGAAC CACGATCAAA ACAACCACAA CACAGACCGG AGCAGCCATA AGGACAGCAT GAACTGACCA CCCTTAGAAG CACTCCTCGG TACTCCCATA ATCCTCTCGG AGAAAAAAAT CACAAGGCAA CTGTGAGTCC GGGAATCTCT TCTCTGATCC rCTrCCrA ATTCACTCCC ACACCCAAGA AGAAATGCTT TCCAAAACCG CAAGGGTAGA CTGGTrATC CACCCACAAC ATCTACGAAT CGTACTTCTT TAATTGATCT AATTTACATA TTCTGCGTGT TGTATrCAGC ACTAAAAAAT GGTGGGAGCT GGGGGAGAAT GAAGACTGTT AAATGAAACC AGAAGGATAT TTACTACITT TGCATGAAAA TAGAGCTTTC AAGTACATGG CTAGUITITA TGGCAGTrCT GGTGAATGTT CAATGGGAAC TGGTCACCAT GAAACTTAG AGATTAACGA CAAGATTC TACTITITIT AAGTGATT TTTGTCCTTC AGCCAAACAC AATATGGGCT CAAGTCACTT TrTATGAAA TGTCATT7GG TGCCAGTATC CCGAATrC-3' (FRAG. NO:__) (SEQ ID NO: 2471) 5'-GAATTCGGGA AAAAGTGAAG GTGTAAAAGC AGCACAAGTG CAATAAGAGA TAT1CCTCA AATTGCCTC AAGATGGAAA CCCTGCCT CAGGGCATCC TTGGCTGG CACTGGTTGG ATGTGTAATC AGTGATAATC CTGAGAGATA WO 00/09525 PCTIUS99/1 77-12 EPI-109 206 CAGCACAAAT CTAAGCAATC ATGTGGATGA ITCACCACT 'IMCGTGGCA CAGAGCTCAG CrrCCTGGT'F ACCACTCATC AACCCACTAA 'ITGGTCCTA CCCAGCAATG G~TCAATGCA CAACTATTGC CCACAGCAGA CTAAAATTAC TTCAGC AAATACATrA ACACTGTGAT ATC11GTACT ATM1CATCG TGGGAATGGT GGGGAATGCA ACTCTGCTCA GGATCATIA CCAGAACAAA TGTATGAGGA ATGGCCCCAA CGCGCTGATA GCCAGTCIG CC=FGGAGA CCT7ATCTAT GTGGTCAT7G ATCTCCCTAT CAATGTA=T AAGCTGCTGG CTGGGCGCTG GCC'IrGAT CACAATGACT 'rGGCGTATT TcT=GCAAG CTGTTCCCCT =IrGCAGAA GTCCTCGGTG GGGATCACCG TCCTCAACCT CTGCGCTCF AGTGTrGACA GGTACAGAGC AGTTGCCTCC TGGAGTCGTG T7CAGGGAAT TGGGATTCCT F7GGTAACTG CCArrGAAAT TGTCTCCATC TGGATCCTGT C=r~ATCCT GGCCATCCT G3AAGCGATTG GCTrCGTCAT GGTACCCTP GAATATAGGG GTGAACAGCA TAAAACCTGT ATGCTCAATG CCACATCAAA ATT1CATGGAG TTCTACCAAG ATGTAAAGGA CTGGTGGCTC T~rCGGGTrCT AmFcTGTAT GCCCTTGGTG TGCACTGCGA TCrCTrACAC CCTCATGACT TGTGAGATGT TGAACAGAAG GAATGGCAGC 7rGAGAAITFG CCCTCAGTGA ACAT=~AAG CAGCGTCGAG AAGTGGCAAA AACAG=I1C TGCTrGGTrG TAANIT1TGC TCTIGCTGG TrCCCTC=C A'I=AAGCCG TATATTGAAG AAAACTGTGT ATAACGAGAT GGACAAGAAC CGATGTGAAT TAC=AGTrT CTFACTGCTC ATGGATF7ACA TCGGTATTAA CTGGCAACC ATGAATrCAT GTATAAACCC CATAGCTCTG TAT1TGTGA GCAAGAAA'Fr TAAAAAflGT UrCCAGTCAT GCCTCTGCTG CTGCTGTrAC CAGTCCAAAA GT~TGATGAC CTCGGTCCCC ATGAACGGAA CAAGCATCCA GTGGAAGAAC CACGATCAAA ACAACCACAA CACAGACCGG AGCAGCCATA AGGACAGCAT GAACTGACCA CCCTTAGAAG CACTCCTCGG TACTCCCATA ATCCTCTCGG AGAAAAAAAT CACAAGGCAA CTGTGAGTCC GGGAATCTCT TCTCTGATCC 'FrCTrCCTI'A ATrCACTCCC ACACCCAAGA AGAAATG=T TCCAAAACCG CAAGGGTAGA CTGWTMATC CACCCACAAC ATCTACGAAT CGTACT7CTr TAATTGATCT AATIACATA 'FrGCGTGT TGTATI7CAGC ACTAAAAAAT GGTGGGAGCT GGGGGAGAAT GAAGACTGIT AAATGAAACC AGAAGGATAT TTACTACTT TGCATGAAAA TAGAGC'=C AAGTACATGG CTAGC'IIA TGGCAGTTCT GGTGAATGT[ CAATGGGAAC TGGTCACCAT GAAAU1TAG AGA'rrAACGA CAAGATITC TAC'TTM~ AAGTGATIT TT17GTCCT7C AGCCAAACAC AATATGGGCT CAAGTCACTT TTIA'IJGAAA TGTCATITGG TGCCAGTATC CCGAAfTrC-3' (FRAG. NO:_) (SEQ ID NO: 2482) 5'-GAATTCGGGA AAAAGTGAAG GTGTAAAAGC AGCACAAGTG CAATAAGAGA TAIT1CCTCA AATTGCCTC AAGATGGAAA CCC'I=GCCT CAGGGCATCC =ITGGCTGG CACTGGTrGG ATGTGTAATC AGTGATAATC CTGAGAGATA CAGCACAAAT CTAAGCAATC ATGTGGATGA 71rCACCACT TIF7CGTGGCA CAGAGCTCAG CTrCCTGGTT ACCACTCATC AACCCACTAA 'I17cGTCCrA CCCAGCAATG GCTCAATGCA CAACTATrGC CCACAGCAGA CTAAAA17AC T7CAGC=rC AAATACATTA ACACTGTGAT ATCTrGTACT A=IICATCG TGGGAATGGT GGGGAATGCA ACTCTGCTCA GGATCATrA CCAGAACAAA TGTATGAGGA ATGGCCCCAA CGCGCTGATA GCCAGTCT7G CC=~GGAGA CCIATCTAT GTGGTCAT-rG ATCTCCCTAT CAATGTAMT AAGCTGCTGG CTGGGCGCTG GCCTITTGAT CACAATGACT TrGGCGTA'T TC1TGCAAG CTGTrCCCCT TI=GCAGAA GTCCTCGGTG GGGATCACCG TCCTCAACCT CTGCGCTCTr AGTGTrGACA GGTACAGAGC AGT7GCCTCC TGGAGTCGTG TrCAGGGAAT TGGGA TFCCT TrGGTAACTG CCATrGAAAT TGTCTCCATC TGGATCCTGT CCT=ATCCT GGCCATrCCTr GAAGCGATTG GCI1rCGTCAT GGTACCCT= GAATATAGGG GTGAACAGCA TAAAACCTGT ATGCTCAATG CCACATCAAA ATFCATGGAG 'FrCTACCAAG ATGTAAAGGA CTGGTGGCTC 17CGGGITCT AITCTGTAT GCC=TGGTG TGCACTGCGA TC'ITCTACAC CCTCATGACT TGTGAGATGT TGAACAGAAG GAATGGCAGC TrGAGAATrG CC~rCAGTGA ACATCTTAAG CAGCGTCGAG AAGTGGCAAA AACAGTITC TGCT7GGTTG TAATITGC TCITGCTGG 'FrCCCTCPTC A'I=AAGCCG TATATTGAAG AAAACTGTGT ATAACGAGAT GGACAAGAAC CGATGTGAAT TAM~AGTr7 CTACTGCTC ATGGA'ITACA TCGGTATIAA CTTGGCAACC ATGAATTCAT GTATAAACCC CATAGCTCTG TAYI=GTGA GCAAGAAATT TAAAAATrGT TFCCAGTCAT GCCTCTGCTG CTGCTGTTAC CAGTCCAAAA GTCTGATGAC CTCGGTCCCC ATGAACGGAA CAAGCATCCA GTGGAAGAAC CACGATCAAA ACAACCACAA CACAGACCGG AGCAGCCATA AGGACAGCAT GAACTGACCA CCCTrAGAAG CACTCCTrCGG TACTCCCATA ATCCTCTCGG AGAAAAAAAT CACAAGGCAA CTGTGAGTCC GGGAATCTCT TCTCTGATCC T7C=CA AT7CACTCCC ACACCCAAGA AGAAATGC'IT TCCAAAACCG CAAGGGTAGA CrGG'ITTATC CACCCACAAC ATCTACGAAT CGTAC'FC= TAATrGATCT AAMrACATA T~CTG3CGTGT TGTAFCAGC ACTAAAAAAT GGTGGGAGCT GGGGGAGAAT GAAGACTGTT AAATGAAACC AGAAGGATAT T1TACTACTF TGCATGAAAA TAGAGCI=C AAGTACATGG CTAGCT1TA TGGCAGTTCT GGTGAATG'Fr CAATGGGAAC TGGTCACCAT GAAAC1TAG AGATrAACGA CAAGATrC TACTITITF AAGTGA=I~ TF7GTCCTC AGCCAAACAC AATATGGGCT CAAGTCA=r TTA7T17GAAA TGTCATIT7GG TGCCAGTATC CCGAATTC-3' (FRAG. NO:_) (SEQ ED NO: 2470) 5'-GCCACCATGG AAACCCITG CCTrCAGGGCA TCCI1TGGC TGGCACTGGT TGGATGTGTA ATCAGTGATA ATCCTGAGAG ATACAGCACA AATCTAAGCA ATCATGTGGA TGAMfCACC ACITCGTG GCACAGAGCT CAGCTTCCTG GTFACCACTC ATCAACCCAC TAATITGGTC CTACCCAGCA ATGGCTCAAT GCACAACTAT TGCCCACAGC AGACTAAAAT TACTTCAGCT TrCAAATACA FrAACACTGT GATATCrrGT ACTA'IICA TCGTGGGAAT GGTGGGGAAT GCAACTCTGC TCAGGATCAT TTIACCAGAAC AAATGTATGA GGAATGGCCC CAACGCGCTG ATAGCCAGTC T17GCCCITGG AGACCTI7ATC TATGTGGTCA T'rGATCTCCC TATCAATGTA TGGCTGGGCG CTGGCCTIT GATCACAATG AC'=GGCGT A TITGC AAGCTGT~rCC CC'IrrGCA GAAGTCCTrCG GTGGGGATCA CCGTCCTCAA CCTCTGCGCT CTTAGTGTTG ACAGGTACAG AGCAGTrGCC TCCTGGAGTC GTGTFCAGGG AA'FrGGGATr CC1rGGTAA CTGCCATrGA AATTGCCTCC ATCTGGATCC TGTCCITAT CCTGGCCATT CCTGAAGCGA 'FrGGCITCGT CATGGTACCC 'TrTGAATATA GGGGTGGACA GCATAAAACC TGTATGCTCA ATGCCACATC AAAATTCATG GAGTFrCACC AAGATGTAAA GGACTGGTGG CTCTTCGGGT TCTA T1CTG TATGCCCT7G GTGTGCACTG CGATCrICTA CACCCTCATG ACTGGTGAGA TGTTGAACAG AAGGAATGGC AGcTrGAGAA TFGCCCTCAG TGAACATCTr AAGCAGCGTC GAGAAGTGGC AAAAACAGT7 'FrCTGCrrGG TrGTAATIT TGCTC1TGC TGGTrCCCTC TTCAMTAAG CCGTATATTG AAGAAAACTG TGTATAACGA GATGGACAAG AACCGATGTG AA'rrAC-rAG 7rrrC7 CTCATGGATr ACATCGGTAT TAACTGGCA ACCATGAATT CATGTATAAA CCCCATAGCT CTGTATITG TGAGCAAGAA ATIAAAAAT TGTrCCAGT CATGCCTCTG CTGCTGCTGT TACCAGTCCA AAAGTCTGAT GACCTCGGTC CCCATGAACG GAACAAGCAT CCAGTGGAAG AACCACGATC AAAACAACCA CAACACAGAC CGGAGCAGCC ATAAGGACAG CATGAACTGA CCACCCTTAG AAGCACTCCT-3' (FRAG. NO:_) (SEQ ID NO: 2469) Substance P Antisense Nucleic Acids and Oligonucleotide Antisense Olijzonucleotide Fra2ments 5'-CTGCTGBGGC UrGGGTCTCC GGGCGBTTrCT CTGCBGBBGB TGCTCBBBGG GCTCCGGCBG TTCCTCCTI'G BTCTGGTCGCT GTCGTBCCBG TCGGBCCBGT BB'FrCBGBTC BTCBrGGCT CCTBTrCTI CTGCBBBCBG CTGBGTGGBG BCBBGBBBBB BGBCTGCCBB GGCCBCGBGG BVFITCBTGT TGGB=TGC GBCGGBCBGT CCCGCGGGGT GCTGAGTC TCTGGTFrCCT CCGBGCGCBC GTGGTCGCTC CGCG'ITrCTC TGc3'FICCTCC GGTCCCGCGG GGTGCTGTCT GGTCGCTGTC GTGGCTI'GGG TCTCCGGGCG G ITCCFCC rI=CCGC-3' (FRAG. NO:1877) (SEQ ID NO: 1888) WO 00/09525 PCT/US99/17712 EPI-109 207 5'-CTCC GGGCGB-3' FRAGG. NO:1878) (SEQ ID NO: 1889) 5'-GGCCBCGBGG-3' (FRAG. NO:1879) (SEQ ID NO: 1890) 5'-GGGTCTCCGGGCG-3' (FRAG. NO:1880) (SEQ ID NO: 1891) 5'-GGG TCTCCGGGCG G-3' (FRAG. NO:1881) (SEQ ID NO:1892) 5'-CGTGGTCGCTCCGC-3' (FRAG. NO:1355)(SEQ. ID NO:1365) 5'-GTTTCTCTGGT'CCTCCG-3' (FRAG. NO:1356)(SEQ. ID NO:1366) 5'-GTCCCGCGGGGTGCTG-3' (FRAG. NO:1357)(SEQ. ID NO:1367) 5-TCTGGTCGCTGTCGT-3' (FRAG. NO:1358)(SEQ. ID NO:1368) 5'-GGCFGGGTCTCCGGGCG-3' (FRAG. NO:1359)(SEQ. ID NO:1369) 5'-GTTTCCTTCCITITCCGC-3' (FRAG. NO:1360)(SEQ. ID NO:1370) 5'-CTGCTGBGGC TTGGGTCTCC GGGCGBTTCT CTGCBGBBGB TGCTCBBBGG GCTCCGGCBG TrCCTCCTrG BTCTGGTCGCT GTCGTBCCBG TCGGBCCBGT BBTTCBGBTC BTCBTTGGCT CCTBTTTCTT CTGCBBBCBG CTGBGTGGBG BCBBGBBBBB BGBCTGCCBB GGCCBCGBGG BTTCBTGT TGGBTITTGC GBCGGBCBGT CCCGCGGGGT GCTGAGTTTC TCTGGTTCCT CCGBGCGCB-3' (FRAG. NO:1882) (SEQ ID NO: 1893) Substance P Receptor Nucleic Acids and Antisense Oligonucleotide Fragments 5'-GGGCTBBGBT GBTCCBCBTC BCTBCCBCGT TGCCCBCCBC BGBGGTCBCC BCBBTGBCCG TGTBGGCBGC TGCCCBBBGG BCBBTTTGCC BGGCTGGTrG CBCGBBCTGB TrGGGTrCCG BGGTGTTBGT GGBGBTGTTT GGGGBGBGGT CTGBGTCCBC CGGGBGGBCG TTBTCCBTIT CGBBGCTBGG CGGTBBBGCC CTBCTBTCTG TBCBCBBCCC CCCTCTGCBG CBGBGTCCTG TCGTGGCGCC TGGGGCTCBG GGTCCGGGC TAAGATGATC CACATCACTA CCACGTTGCC CACCACAGAG GTCACCACAA TGACCGTGTA GGCAGCTGCC CAAAGGACAA TTGCCAGGC TGGTTGCACG AACTGATTGG GTrCCGAGGT GTrAGTGGAG ATGTTGGGG AGAGGTCTGA GTCCACCGGG AGGACGTTAT CCATTCGAA GCTAGGCGGT AAAGCCCTAC TATCTGTACA CAACCCCCCT CTGCAGCAGA GTCCTGTCGT GGCGCCTGGG GCTCAGGGTC CGTCCTGTCG TGGCGCCTGG GGCTCTTCTT TTGTGGGCTC TTGGTGGCT GTGGCTGTGG TCTCTGTGGT TGCTGCCCTG GGTCTGGGGG TGTGGCCTTG GGGCCGTCCT CTGGCTCCTC CTCGTGGGCC CCC-3' (FRAG. NO:1883) (SEQ. ID NO:1894) 5'-GGGBGGBCG-3' (FRAG. NO:1884) (SEQ. ID NO:1895) 5'-GGGTC CG-3' (FRAG. NO:1885) (SEQ. ID NO:1896) 5-'GGGCC CCC-3' (FRAG. NO:1886) (SEQ. ID NO:1897) 5'-GTCCTGTCGTGGCGCCTGGGGCTC-3' (FRAG. NO:1361)(SEQ. ID NO:1371) 5'-TTC-ITI'GTGGGCT-3' (FRAG. NO:1362)(SEQ. ID NO:1372) 5'-CTTGGTGGCTGTGGCTG-3' (FRAG. NO:1363)(SEQ. ID NO:1373) 5'-TGGTCTCTGTGGTTG-3' (FRAG. NO:1364)(SEQ. ID NO:1374) 5'-CTGCCCTGGGTCTGG-3' (FRAG. NO:1365)(SEQ. ID NO:1375) 5'-GGGTGTGGCCTTGGGGCCGTCCTCTGGCTCCTCCTCGTGGGCCCCC (FRAG. NO:1366)(SEQ. ID NO:1376) 5'-GGGCTAAGAT GATCCACATC ACTACCACGT TGCCCACCAC AGAGGTCACC ACAATGACCG TGTAGGCAGC TGCCCAAAGG ACAATTTGCC AGGCTGGTTG CACGAACTGA TTGGGTTCCG AGGTGTTAGT GGAGATGTTT GGGGAGAGGT CTGAGTCCAC CGGGAGGACG TTATCCATTTC GAAGCTAGGC GGTAAAGCCC TACTATCTGTA CACAACCCCC CTCTGCAGCA GAGTCCTGTC GTGGCGCCTG GGGCTCAGGGTCC-3' (FRAG. NO:1367)(SEQ. ID NO:1377) 5'-GGGCTBBGBT GBTCCBCBTC BCTBCCBCGT TGCCCBCCBC BGBGGTCBCC BCBBTGBCCG TGTBGGCBGC TGCCCBBBGG BCBBTGCC BGGCTGGTTG CBCGBBCTGB TTGGGTTCCG BGGTGTTBGT GGBGBTGTT GGGGBGBGGTC TGBGTCCBCC GGGBGGBCGT TBTCCBTTTC GBBGCTBGGC GGTBBBGCCC TBCTBTCTGTB CBCBBCCCCC CTCTGCBGCB GBGTCCTGTC GTGGCGCCTG GGGCTCBGGG TCC-3' (FRAG. NO:1368) (SEQ. ID NO:1378) Chymase Antisense Nucleic Acids and Oli2onucleotides Antisense Oligonucleotide Fragments 5'-GGBGCTGBTB CTGCBGATTT CBGBGGGBBG BBCCCTGBTB CTCBCCBGCT TCBGCTCTGG BGCBCBBGBG BBBGBGCBGC BGGGGGBGBG GBBGBBGCBG CBTCTTCCCB GBGBGGCTGC CTGBGCBBBT GCTGGTTTC CTTTCCBGTC TTGGGTB TBBCTCCCBG BBGGCBBGBG BGGGGCBBGG CGITCTTC TCTCGCTGGT TTTCCTCC TGGCAGTGGG TGGGGGTGGG GGTGGGGTGG CTTCCTTGTT CCTGGGGGTG TCCTCTTGCT CTGGGCUITT CTCCCCITIT CCTTCCTGTC TG1IrCCTG GGGCTCTCCT CTGTCTCTGT GTCCTTGCCC TGGCCCTCTT CCCTCTCCTG TCTCCTGTCC CTGTGTTCCG CCCGTCTTCC CTCTCCTGAC CTCCITITCC TCCGCTGGGT GGGGCCCTGC CTGTTCTCTG CTCCCTGGCT TGGGGTCT TCTGTGTGTC TTCTTCCTCT GTTGGCTGGC TTTCTCCTTC TTGTCTTC CTGGGTGCCC CTTCTTCCT TCTTGGGTCC TTGGTGCTG GGCTGGG TCCCAGTTAA TACATAATCA ATATGCAATT TATTAATACA TCTCTCCATG TCCACTCCCC CTGTATCTTG CCATTCTTGA CCTGCATTTC CATCCTCCTT ACCTTCCCTA GAGGCCAACT CA=TTCT GAAAAACCTG GCATTTCCCA GAAAAAAAAG TGAAGGGCTG GGAGCTGTCC GTTGTCCTGA TTGCTCCCT CTGCCCTTGC TTCCAAATGT GGTTGGAAAG AAGCACTATT GAAAAATCCC TAAACGCACC CCTGCAGGGT TGGCTCTACC CTGTAGCCAT GGACACATGC TGTTGATACC ACCrGCCTCA TGAGTCTCAC ATAATGCC CTTTCACACT ATCTACCCCA TCAGCCITAC CAAAACCATA CCTGCATCCT GGGCAGCATC TGCCCTTCAA GAGACTAAGG AATCTCCTTG CAACCAAGAA TGACTAGACC AATGAGACAC CCTAAGGC CCCAGCACAA TATAGAAATC CCACAATATG GTAATCCCAG TAAGGAGCTA TCAAGCCATT GCAGGACCAT CTAGAATACA ACTAGAGTAT AGTTCCTC AATCCAGGAA CTATACTCTA ACAGCTTGGC TCACAGGAAC CAGAAGTGAA GATGATGAGG ATCAGGGCTG AGCCTGTGAG CACCAGCTCC ACCACTGACA CCAACCACAG ATTAAACAAG CATCTTGTGG ACCCCTGGGA TGGAAAGAAT AGTTGTTGCC TTATCAACCT CCCCCACAGC CCACACAGAA AAGATAAAAT CATCATGGCT ACAGTGTTAC AGAAGATGAT GACCCAAGGA GTAGGCCTGC CTGAGTGAAT GCTGAGAGTG ATAATGGGAG CAGTAGCATC TCAGAGACTA CAGCAGAAAC CATCCACATA AAGAGCTTG CCCAAACTTA TGATAAAGGG CACCCTCAGA GACTCTCCCT ACTTAATAT TAGCCCATTG CAGAAATGGT GAGTGGAAAG AGAAATCTTA GGAAGAACCC CTTAAAAAAG CAAAATGCTT TTTAGG=TTG TGCTGAAGAG CCTGGAAAAG AAATAAGGAC ACACACGCTG AGAAATCTC CTCCTGCCCC AACACTGGGA TAATCTCCAA GGATCTCTCC ATATCTCAT CTCCTGGATA CACTGTCCAC TCAGAAATAT TGTGCAGAGT GCAGTAATIrC AAAAGTGAGC TATTGTGTTA GGAGTGAAGG CAAGAGTATC GTAAAATAAA TCAAATTTGA AATGAATTrCT CTTAAATTGC TATAGATG TAATGTAA GCCAGCAGCT ATTAAACGAT AAACCTTAAA TrCGAGAAAA ACTTGGTCAT TCAGAAACTA TAGAAACAGG CAGGACTTAT TGCGAGGGCA AACACAGAGT GAGCTCCAGC CTGCTTCAGG AAAATCTGCC AGTGCCATGA AGGATGTACT CTGTCTGCTC CACTGCACTA CTGC TCAGTA TGAGCCCATG CCATCAGCTG TCCCTGACCC ACAGGAGTTC TTTAGAAGAG ACTGGTCAAC AAAAGTTTCT AGGGTGTT ATACCTGCCA ACTCGAGGGT TAAAACAAGT TGCATAGAAA TGCTCAATCA WO 00/09525 PCTIUS99/1 77-12 EPI-109 208 AGAAAGACAC AGTCA'ITACT CAGAGAATAA TAAACAGCCT GGCAGCACAT GAATGAATAG AAAAAAGATG TTACATGCAA AGCATGAAAT AACCAAATFC CATAACAGAT G'TrAATCTGT AATGTGrITA GGAGAAMA GAGGAAGTAT AAGAMTrr CTICATCAA AAAAAflATA GCCAATGAGG ATATATCTAT CAATrATCCA TCAAGTGGTG ATATGGCAGC ACAAGGTAAA ACACAAAGGA ATAAAACCAA CGMIATTAA GAACCAATCA TGTGGCATr CACATTGAGC ATCATATTTA ATTCTGAAAA AAATCCTGT ACTGTATCAT TCTTCATAT7T7FATGGATGC AGTAACTAAG GCTGAGAACT TrAAAATIT TCCTAAGTTC AGACACATAG CTAAGTGGCA GAACCAAGAT TCAAACTCAC CCCATCTAAC TGCAGAGCAA ACTGCATGCC TrFAAATGTCA AAGTGAATAC TAGCACAGTT AATACAATGT TFGGAAACTC AGAGAAGGAA TGATCCCTCT GCA'ITATAGT TACTAAGGAA TCATTGCCAT TATTrAAATG CCAGTG=TC TACATCAGGC CCAAA=F~C TGTCCTACTA ACTGTGAATC AAGAcTrGAT TCAACCTCTA CT7GAGTATC TGCCGCAATG AGAAATCACT TACCTCCACT AACCACACAT TrA=TATA ACAACAGAT7 GT7AGTAAGT CCTCAT ACATACTCAA CAGCTG=rC CCAAGATGCT GTAGGA ITAT GTCTAGAGTC AAACTAGCCA GAAGCAATGT CCAAAATACA CCATAACACT GTGCAGCAAA GGTCCTACTA CCACT-rG7T1r GGCCCAAACA T~cTAGGCAG CACTGGATAT CTGAATCATC AA'rrA'I=CC ACAAACACTG ACCCCTCTAC CAGTCACCCT CACTAGAAGA ATrAA~rCCA CATGATAATA GCTCCCTCAT GTrACTCCCT TCTAAGTCAA ATFIGTACACC CC'T1ATCTG ATTAACAGAG TCTAAGTCAC ATGACCTAAA TGCAAGAGAA CTGGGAATGG ACGTI1GTGG AT7CTACCFT AGTAAGGCAA AG FTATCATT GGGAATTCCT CrAATACAGG AAGGGTGTTC CAGAGACATr AAGGAGCCAT ATAAATGGAA AATGTCCACT ACAATCCATC ACTTGGflGC CCCACATCAA CATTCATTCT TITGCCACAC T-rAAAGTrC CAAGAACAAA AATrATCCCA CTGAACATAA TCTFACTAT CT=rATATA AAGGAAAATI' AGACTrGACT CAGCAGAACT GAAATAACCC AGCTCTAACA G7FACTGCTr 'ITAACITCAA GTACTGTGTC TCTAGGTGAT ACCTGCTCCA ACAATAGITT GGTCACA'ITr TCAAnI1GAT A FI7CTCTAGT CTCCCAACTT GATAACTG1TA CCCTAAACCA TAAAGTrCAC TACCAACATG CTATATATAA AATAACCAAA GGGGGAAGAA GAAAGAGAAA AAGGAAATCT C'IAAAATAC ACAGGTATAC ATATGACAAA GCAAAGAAGG AAATGTGAGC AGATAGTGCA GTCCTCGT17 CrGAAATF7GG TCCCCTGACT GGGGCTATAC CTATrCCA'Tr TCCTCACCCT CAGCCAGGCA GGTGGAGCAA AAACITAAGT CTGGTGGAT CTGAAT=TG ATGCTGTGGA GCTGTCTTAC TAGCCCCAGA CTACCTGCCT CTCAA TrCT AATTATATCA GTGAAAGCAA ACAG='~GA T'7TTA CCTCTGATT7 MTGGTCTAA CTGATGTAAG ACCACAAGGA CAAGAGTTCT CCAGCTCCGG ATTCTC17CT GFI'CTGTTAA TGGTGAAATG CCCGAGAGAA GAGTTGCCAA C1TGGCAAA TAAAAAATAC AGGATrCCAG TTAAA'rTCAA ATTTAGATAA ACAACAATr7 T7AGTATTA GTGTGTCCCA TFrCAATA'T7 GGACATACTT AACTAAAAAA TGAT1TT~G TT7CATCTGAA ATACAAAn7~ AA CTGGGCAT TCTGAATATr cTrCTGGCAAC CCCCGAGAGA GTGAAGAAAG TGGTACAAGG ACACITAAGA AGACCAGATT TGAAAAGACA TTACGGATGT G'I1rAAATGT cTrATTCITAG AGAGAG'I1AG AGCTGTAGGT AGAACTGGG AAAflAAG17 AAAAGCAGAC ACAGAGACCT GGCCAATATA TACTAAGGAG TGGATCACTC TGGTCACAAG CCCAACCTGA GACCAAGGGC ATAGTGAGAT GAT-17GGGAA AGGCACT7AT ACACTAU1rCA TCCCCGT=T TGAACTAAAT GCCT7ATAAA TCTCCAAGAG AAATGACAGT CCACCATGTG GACTGC'=C TGTAAGTCCA GGGAAAATAA AAGCTATGTG CrGAAACCC ACrGATA TTATAAGGTG TGTGATCTF GTCATGTTAA TGGGTCTGAG TATCAAT7CT ACAATrGTAA AGTGACAGTA ATGGTGTGTC CCCAGG'TGT TGTGGAAAGC 'FrGATrCTrTA ATGCAACAGT AGGAAACCCC AGCCTCrCTG GAGCAAACAC CCTACAT crrrCTTCC CCTGCACATT GGCAGGACTC TATrTCCTCTA TICTCTCTA GTGCTAGAGC AGAAAGGGAC CTrGAMrGA TATCAGGAAA ATCTATVFCT GAACCATAAG CTATGATAGC TGAMIAAAA AATGACTAT CATGACATGA TAATGATCAT AATGGTAATA CATAT1TGATA GGGTTGCCGT GAAAGTAATA ATATATCTAA GAGTTGTGAC AATATATGAT ACGCCTAGAC TCTCAGAAAA TGCTAATrCC AATCCCAATr GCTCTIGCA TAAAGTrC-rG TCCTAGGGTC TGT7CTMTC CCACATCTAC CCTCCTTGGA TCrCTCrrCT GTCTITCA TGTGGTTCAG AGGAGGAGAG AGATCCAGGT CAATGTT CAAAT7ACAA GGAA17ATCA MrAAATGGG GAAGAAGCTC AAG=IIGAC GTGTAGTGGA A~rGGAGTGG AGTGGAGTGG AATGGAAACT AACAGGAAGA CACTGCACAT GGTTAAGATA AAGAn7GT'1r CCTGAAACCT TrAAM~GTG CTACATACT CACACATACA TATGTGCATG CACTGGGACT CTGCAATATG CA1TTcTGAC TATGGAACAT AGCCATAAAA GTCTFGCAC TGAACGTTCA GTGGGCCIT CACAAG(7TGC CCTAATrGGG AAAGAAAAAC ATGGTCCCTC CAT7CCTGC CCCCAACTCC AGAAAAGTCA CCATAGTrGA GGGTACATCT GAGAAGCCAG CACTTrGGGAG 'rrCAGGGCTC AAG'TrCC1 CTAGAAAAAC ACTGGGTGAT TCTAGGGGAA CTCCGATCA GAAACAGCCA ATTCAGAGTG AGAGAAGAAA ACGTGACCAT GCAGT7CCTG TGG'ITACCAG CCTTGCCCCT CTrCT7GCCTF CTGGGAGT7A TAAAACCCAA GACTGGAAAG GAAAACCAGC AnI7GCTCAG GCAGCCTCTC TGGGAAGATG CTGCTI'Cf7C CTCTCCCCCT GCTGCT='~ CTCrrGTGCT CCAGAGCTGA AGCTGGTGAG TATCAGGGT7 CTTCCCTCTG AAATCTGCAG TATCAGCTCC TGAAACAAAG ATG ITAGTC TGAAATAGCT GACTCCTAAA CAGGGTTCCA AGATCTCTCT TCAAGAGTCC CACAGAGGAA ATI1rCCACTh? GGGATGTGTG CCACCCCACC CCCACCCCCA CCCACTGCCA TrCTCTACAG CCTAGGACAC CCCCAGGAAC AAGGAA'T'C ACCTCAAT7G TAGAAAAGCC CAGAGCAAGT GGAAGGAAAA GGGGTATCCC CAGGAAAACA GACATGTCCT CTrAATCTTC TGAGCATCAG GGCTACCCAT TACTIGTGA =1TCTCACT CTGTGACCAT GCTCAAGAGC TATGGAGAAA TCTAAAACAG GAACCTGGAC AGTGGGTCCTr ACACAGAGAC AGAGGAGAGT GGGCCAGGGC AAGGTGGGAG TGGGAGAAGT CTGAGATGAA AACATCAGAA TGGAGCAGAG GCAAGAATGA GATI7CACCr GGGAGGFI7AT GGGTGGGGAA AGATACGAAA TACAGGAGAC AGGAGAGGGA AGATGGGCGG AACACAGGGT GAGAATGAGA rCCAGGGAA GCCTAGCTCA GC'TIAACCC AAThITGTCCA TrCATrGGAG AGAGTATCTA TGGCCGTGTT CAAACCCrGG GGTGCTWrGT TCCAGGGGAG ATCATCGGGG GCACAGAATG CAAGCCACAT TCCCGCCCCT ACATGGCCTA CCTGGAAATI' GTAACTrCCA ACGGTCCCTC AAAA=rTGT GGTGGTICC TrATAAGACG GAA=1IGTG CTGACGGCTG CTCAT7GTGC AGGAAGGTGA GACAACAGGG TCTKITrATC TCCAAATGGG AGATGAACAA CCAGAGTAGC ATCCAGGAAT ACACCTGCAC TGGGGACTGA AGAGGGGGTC CTGGGTCTTrG TCAACTICA GGAGAGGGAA GACI=GGGC TGAAAGACT TAGTCTGTGT 'VrGAATAG'Fr C=TGAGCCT CAGTCACTGA GCTAAGCTCC CT7CGGAGGA AAAGGAGGTC CTGTCCGAAG GTCCCTCTG TTGCAGTAGC ACCCCTCACC CCTACCCAAC TCAAGACACA CGGCTCACT T17CAGGGCCC CACCCAGTCT CAGGGCCACT TCCTCTATGG CCTI=CAAG AACACTGGCT CTAG'rCTCA GGGTCCTGAA CCCATCKIM TATGGGAGCA GAGAACAGGT CTACATAAGA CCCCCAC'rrr CCCGTI=AA CTGATATCTC CTGCTrCAGG GGCTGGCCCT CATGCAGGGT TCCCTGAMTT AGGAAGTGTG AACCCTGTCC CCTGAGTCCT CCCTrGGCCTG TTCAGTCCCC AGCAATrCCA GGGGTCGTAG AAATrGTGTC TGTI7CCrGA GAAAGCrC= TCATGAGTF[A AGCCTGAGCC CTCAAATGCC ACAAGTGGCC CATGAAAAGG GAGATGGGTA GAGTCCGGCN ACCCAGTGAC AGAGT1ITAGT CCTCTITCT CAGAATGAGC TCACCTCAGA AGAAACCCCA AGCCATCACT GTCGCCTCCT TTCTTCCT TCITCCTCAC AGCAGGTCTA TAACAGTCAC CCT7GGAGCC CATAACATAA CAGAGGAAGA AGACACATGG CAGAAGCTG AGGITATAAA GCAATTCCGT CATCCAAAAT ATAACACTC TACTCT7CAC CACGATATCA TGTTACTAAA GGTGACAACA CCTCrC7CT CCCTTCCAC 'PTCCCA'ITCT CCTAAGCTrC TC=TCAGGT CCTCAT7GCC CTGAATI=r CTAGGACTT GGCTATAACA TGAAGCTACT CACCCTGTCC CTCCCTGATC ACCTCCAACT GTCCAGAGCC CATTrCGAGG ACTGACAGTC CTTCAT7CCC WO 00/09525 PCT/US99/17712 EPI-109 209 TTCACAGTTG AAGGAGAAAG CCAGCCTGAC CCTGGCTGTG GGGACACTCC CCTTCCCATC ACAATTCAAC TTT'GTCCCAC CTGGGAGAAT GTGCCGGGTG GCTGGCTGGG GAAGAACAGG TGTGTTGAAG CCGGGCTCAG ACACTCTGCA AGAGGTGAAG CTGAGACTCA TGGATCCCCA GGCCTGCAGC CACTTCAGAG ACTTTGACCA CAATCTTCAG CTGTGTGTGG GCAATCCCAG GAAGACAAAA TCTGCAITA AGGTGATCCT CCAACTAGGT TTCCTCTCCA AAACTCACTG TTCAGGGACC TGAATGCTCT TAGAAGGAGA TGGGGTCAGC AGGTrGTCAG TCAGGTGACA GGGTGAGCAT CACAGGAATT GCTGTCCTCC CGTGGTCCAA GACAGCCTCT GACCATCCAT TCCAGTCTAC TGCACTGGGG GCATGGGGTG ACTGTGGAGA ATGTGGATGA CGGTCCCAAG AAAGGAAGAA GGGGCATCAG AACTAGATGT ATAAGTGAGG AGCTCCACCT CCTGGGTCTG ACTTTAGGTC TCACTGTGAC TCCAAGCTGG CTGGCAGACA GGAGTGGAGG ACTTCCCGGG CTCACCTTCT TCTCTCTCTC CTCCCCCTAC AGGGAGACTC TGGGGGCCCT CTTCTGTGTG CTGGGGTGGC CCAGGGCATC GTATCCTATG GACGGTCGGA TGCAAAGCCC CCTGCTGTCT TCACCCGAAT CTCCCATTAC CGGCCCTGGA TCAACCAGAT CCTGCAGGCA AATTAATCCT GGATCCTGAG CCAGCCTGAA GGGAAGCTGG AACTGGACCT TAGCAGCAAA GTGTGTGCAA CTCATTCTGG TTCTACCCT GGTTCCCTCA GCCACAACCC TAAGCCTCCA AGAGGTCTCC TACAGGTAAC AGAACTTCA ATAAACTTCA GTGAAGACAC AGCTTCTAGT CGTGAGTGTG TGTCCCTCTC TGCTGCTCTC TTCTCCTGCA CATGTGACCT GATTCCCAGC CCAAGCACCA AGGA ATCATCGGGG GCACAGAATC CAAGCCACAT TCCCGCCCCT ACATGGCCTA CCTGGAAATT GTAACTCCA ACGGTCCCTC AAAATITGT GGTGGTTTCC TrATAAGACG GAACTGTG CTGACGGCTG CTCATTGTGC AGGAAGGTCT ATAACAGTCA CCCTTGGAGC CCATAACATA ACAGAGGAAG AAGACACATG GCAGAAGCTT GAGGTTATAA AGCAATTCCG TCATCCAAAA TATAACACTT CTACTCTTCA CCACGATATC ATGTrACTAA AGTTGAAGGA GAAAGCCAGC CTGACCCTGG CTGTGGGGAC ACTCCCCTTC CCATCACAAT TCAACTTTGT CCCACCTGGG AGAATGTGCC GGGTGGCTGG CTGGGGAAGA ACAGGTGTGT TGAAGCCGGG CTCAGACACT CTGCAAGAGG TGAAGCTGAG ACTCATGGAT CCCCAGGCCT GCAGCCACTT CAGAGACTTT GACCACAATC TTCAGCTGTG TGTGGGCAAT CCCAGGAAGA CAAAATCTGC ATTTAAGGGA GACTCTGGGG GCCCTCTTCT GTGTGCTGGG GTGGCCCAGG GCATCGTATC CTATGGACGG TCGGATGCAA AGCCCCCTGC TGTCTTCACC CGAATCTCCC ATTACCGGCC CTGGATCAAC CAGATCCTGC AGGCAAATTA A-3' (FRAG. NO:1887) (SEQ. ID NO:1898) 5'-ATCATCGGGG GCACAGAATC CAAGCCACAT TCCCGCCCCT ACATGGCCTA CCTGGAAATT GTAACTTCCA ACGGTCCCTC AAAATTTTGT GGTGGTTTCC TTATAAGACG GAAC=TrGTG CTGACGGCTG CTCATTGTGC AGGAAGGTCT ATAACAGTCA CCCTTGGAGC CCATAACATA ACAGAGGAAG AAGACACATG GCAGAAGCTT GAGGTTATAA AGCAATTCCG TCATCCAAAA TATAACACTT CTArCTTCA CCACGATATC ATGTTACTAA AGTTGAAGGA GAAAGCCAGC CTGACCCTGG CTGTGGGGAC ACTCCCCTTC CCATCACAAT TCAACTGT CCCACCTGGG AGAATGTGCC GGGTGGCTGG CTGGGGAAGA ACAGGTGTGT TGAAGCCGGG CTCAGACACT CTGCAAGAGG TGAAGCTGAG ACTCATGGAT CCCCAGGCCT GCAGCCACTT CAGAGACITT GACCACAATC TTCAGCTGTG TGTGGGCAAT CCCAGGAAGA CAAAATCTGC ATTITAAGGGA GACTCTGGGG GCCCTCTTCT GTGTGCTGGG GTGGCCCAGG GCATCGTATC CTATGGACGG TCGGATGCAA AGCCCCCTGC TGTCITTCACC CGAATCTCCC ATrACCGGCC CrGGATCAAC CAGATCCTGC AGGCAAATTA A-3' (FRAG. NO:) (SEQ. ID NO:2467) 5'-TCCCAGTTAA TACATAATCA ATATGCAAT7 TATTAATACA TCTCTCCATG TCCACTCCCC CTGTATCTTG CCATTCTTGA CCTGCATTTC CATCCTCCTT ACCTTCCCTA GAGGCCAACT CATITCTTT GAAAAACCTG GCATTCCCA GAAAAAAAAG TGAAGGGCTG GGAGCTGTCC GTTGTCCTGA 'ITGCTCCCT CTGCCCTTGC TTCCAAATGT GGTTGGAAAG AAGCACTATT GAAAAATCCC TAAACGCACC CCTGCAGGGT TGGCTCTACC CTGTAGCCAT GGACACATGC TGTrGATACC ACCTGCCITCA TGAGTCTCAC ATAATTTGCC CITTCACACT ATCTACCCCA TCAGCCTTAC CAAAACCATA CCTGCATCCT GGGCAGCATC TGCCCTTCAA GAGACTAAGG AATCTCCTrG CAACCAAGAA TGACTAGACC AATGAGACAC CCTMTAAGGC CCCAGCACAA TATAGAAATC CCACAATATG GTAATCCCAG TAAGGAGCTA TCAAGCCATr GCAGGACCAT CTAGAATACA ACTAGAGTAT AGTTCCTTC AATCCAGGAA CTATACTCTA ACAGCTTGGC TCACAGGAAC CAGAAGTGAA GATGATGAGG ATCAGGGCTG AGCCTGTGAG CACCAGCTCC ACCACTGACA CCAACCACAG ATTAAACAAG CATCTTGTGG ACCCCTGGGA TGGAAAGAAT AGTTGTTGCC TTATCAACCT CCCCCACAGC CCACACAGAA AAGATAAAAT CATCATGGCT ACAGTGTTAC AGAAGATGAT GACCCAAGGA GTAGGCCTGC CTGAGTGAAT GCTGAGAGTG ATAATGGGAG CAGTAGCATC TCAGAGACTA CAGCAGAAAC CATCCACATA AAGAGCTTTG CCCAAACTTA TGATAAAGGG CACCCTCAGA GACTCTCCCT ACTTTAATAT TAGCCCATTG CAGAAATGGT GAGTGGAAAG AGAAATCTTA GGAAGAACCC CTTAAAAAAG CAAAATGCTT TTTAGGTTTG TGCTGAAGAG CCTGGAAAAG AAATAAGGAC ACACACGCTG AGAAATCTTC CTCCTGCCCC AACACTGGGA TAATCTCCAA GGATCTCTCC ATATCTCATT CTCCTGGATA CACTGTCCAC TCAGAAATAT TGTGCAGAGT GCAGTAATrC AAAAGTGAGC TATTGTGTTA GGAGTGAAGG CAAGAGTATC GTAAAATAAA TCAAATTTGA AATGAATTCT CTTAAATTGC TTTATAGATG TTTAATGTAA GCCAGCAGCT ATTAAACGAT AAACC=TAAA TTCGAGAAAA ACTTGGTCAT TCAGAAACTA TAGAAACAGG CAGGACTTAT TGCGAGGGCA AACACAGAGT GAGCTCCAGC CTGCTTCAGG AAAATCTGCC AGTGCCATGA AGGATGTACT CTGTCTGCTC CACTGCACTA CTGCTCAGTA TGAGCCCATG CCATCAGCTG TCCCTGACCC ACAGGAGTTC MAGAAGAG ACTGGTCAAC AAAAGrCT AGGGTGTT ATACCTGCCA ACTCGAGGGT TAAAACAAGT TGCATAGAAA TGCTCAATCA AGAAAGACAC AGTCATTACT CAGAGAATAA TAAACAGCCT GGCAGCACAT GAATGAATAG AAAAAAGATG TTACATGCAA AGCATGAAAT AACCAAATTC CATAACAGAT GTTAATCTGT AATGTGTTA GGAGAAnTA GAGGAAGTAT AAGATTTATT CTCATCAA AAAAATTATA GCCAATGAGG ATATATCTAT CAATTATCCA TCAAGTGGTG ATATGGCAGC ACAAGGTAAA ACACAAAGGA ATAAAACCAA CGTTTATTAA GAACCAATCA TGTGGCATTT CACATTGAGC ATCATA'TTA ATTCTGAAAA AAATCCTTGT ACTGTATCAT TCTTCATATT TTATGGATGC AGTAACTAAG GCTGAGAACT TTAAAATTTT TCCTAAGTTC AGACACATAG CTAAGTGGCA GAACCAAGAT TCAAACTCAC CCCATCTAAC TGCAGAGCAA ACTGCATGCC TTAAATGTCA AAGTGAATAC TAGCACAGTT AATACAATGT TTGGAAACTC AGAGAAGGAA TGATCCCTCT GCATTATAGT TACTAAGGAA TCATrGCCAT TATTTAAATG CCAGTGCTrC TACATCAGGC CCAAAT=TTC TGTCCTACTA ACTGTGAATC AAGACTTGAT TCAACCTCTA CTTGAGTATC TGCCGCAATG AGAAATCACT TACCTCCACT AACCACACAT TTAT1TTATA ACAACAGATT GTTAGTAAGT CCTTTCTTAT ACATACTCAA CAGCTGCTTC CCAAGATGCT GTAGGATTAT GTCTAGAGTC AAACTAGCCA GAAGCAATGT CCAAAATACA CCATAACACT GTGCAGCAAA GGTCCTACTA CCACTTGT17 GGCCCAAACA TTCTAGGCAG CACTGGATAT CTGAATCATC AATTATITCC ACAAACACTG ACCCCTCTAC CAGTCACCCT CACTAGAAGA ATTAATTCCA CATGATAATA GCTCCCTCAT GTTACTCCCT TCTAAGTCAA ATTGTACACC CCTATCTG ATTAACAGAG TCTAAGTCAC ATGACCTAAA TGCAAGAGAA CTGGGAATGG ACGTTTGTGG ATrCTACCTT AGTAAGGCAA AGTTATCATr GGGAATTCCT CTAATACAGG AAGGGTGTTC CAGAGACA'TT AAGGAGCCAT ATAAATGGAA AATGTCCACT ACAATCCATC ACTTGGTTGC CCCACATCAA CATTrCATTCT 'TGCCACAC TTAAAGTTTC CAAGAACAAA AATTATCCCA CTGAACATAA TCTTACTAT CTTTTATATA AAGGAAAATT AGACTTGACT CAGCAGAACT GAAATAACCC AGCTCTAACA GTTACTGCTT TTAACTTCAA GTACTGTGTC TCTAGGTGAT ACCTGCTCCA ACAATAGTIT GGTCACATTT TCAATTGAT ATTCTCTAGT CTCCCAACTT GATAACTGTA WO 00/09525 PCT/US99/17712 EPI-109 210 CCCTAAACCA TAAAGTTCAC TACCAACATG CTATATATAA AATAACCAAA GGGGGAAGAA GAAAGAGAAA AAGGAAATCT CTTAAAATAC ACAGGTATAC ATATGACAAA GCAAAGAAGG AAATGTGAGC AGATAGTGCA GTCCTCGTTT CTGAAATrGG TCCCCTGACT GGGGCTATAC CTATTCCATT TCCTCACCCT CAGCCAGGCA GGTGGAGCAA AAACTTAAGT CTTGGTGGAT CTGAATCTTG ATGCTGTGGA GCTGTCTTAC TAGCCCCAGA CTACCTGCCT CTCAATTTCT AATTATATCA GTGAAAGCAA ACAGCTTGA TTTGTTTAAG CCTCTGATTT TTGGTCTAA CTGATGTAAG ACCACAAGGA CAAGAGTTCT CCAGCTCCGG ATTCrCTCT GTTCTGTfAA TGGTGAAATG CCCGAGAGAA GAGTTGCCAA CTTTGGCAAA TAAAAAATAC AGGATTCCAG TTAAATTCAA ATTTAGATAA ACAACAAT TAGTATTA GTGTGTCCCA TTCAATATTT GGACATACTT AACTAAAAAA TGA'TTGTTG TrCATCTGAA ATACAAAT AACTGGGCAT TCTGAATATT CTCTGGCAAC CCCCGAGAGA GTGAAGAAAG TGGTACAAGG ACACTTAAGA AGACCAGATT TGAAAAGACA TTACGGATGT GTTTAAATGT CTrATTCTAG AGAGAGTTAG AGCTGTAGGT AGAACTTGGG AAATTAAGTT AAAAGCAGAC ACAGAGACCT GGCCAATATA TACTAAGGAG TGGATCACTC TGGTCACAAG CCCAACCTGA GACCAAGGGC ATAGTGAGAT GA1TTGGGAA AGGCACTTAT ACACTACTCA TCCCCGTCTT TGAACTAAAT GCCTTATAAA TCTCCAAGAG AAATGACAGT CCACCATGTG GACTGCTC TGTAAGTCCA GGGAAAATAA AAGCTATGTG CTrGAAACCC ACTTCTGATA TTATAAGGTG TGTGATCTT GTCATGTTAA TGGGTCTGAG TATCAATTCT ACAATTGTAA AGTGACAGTA ATGGTGTGTC CCCAGGTTGT TGTGGAAAGC TTGATTCTTA ATGCAACAGT AGGAAACCCC AGCCTCTCTG GAGCAAACAC CCTTCTACAT CTTTACTTCC CCTGCACATT GGCAGGACTC TATrCCTCTA TTTCTCTCTA GTGCTAGAGC AGAAAGGGAC CTTGATITGA TATCAGGAAA ATCTATTTCT GAACCATAAG CTATGATAGC TGATTTAAAA AATTGACTAT CATGACATGA TAATGATCAT AATGGTAATA CATATTGATA GGGTTGCCGT GAAAGTAATA ATATATCTAA GAGTTGTGAC AATATATGAT ACGCCTAGAC TCTCAGAAAA TGCTAATTCC AATCCCAATT GCTCTTGCA TAAAGTTCTG TCCTAGGGTC TGTTCTITrC CCACATCTAC CCTCCTTGGA TCTCTCTTCT GTCITTCA TGTGGTTCAG AGGAGGAGAG AGATCCAGGT CAATGTIi CAAA17ACAA GGAATTATCA TTAAATGGG GAAGAAGCTC AAGTTGAC GTGTAGTGGA ATTGGAGTGG AGTGGAGTGG AATGGAAACT AACAGGAAGA CACTGCACAT GGTTAAGATA AAGATTGTTT CCTGAAACCT TTAATTTGTG CTrACATACT CACACATACA TATGTGCATG CACTGGGACT CTGCAATATG CATTTCTGAC TATGGAACAT AGCCATAAAA GTCTTTGCAC TGAACGTTCA GTGGGCCTTT CACAAGCTGC CCTAATTGGG AAAGAAAAAC ATGGTCCCTC CATTTCCTGC CCCCAACTCC AGAAAAGTCA CCATAGTTGA GGGTACATCT GAGAAGCCAG CACTTGGGAG TTCAGGGCTC AAGTTCCTFT CTAGAAAAAC ACTGGGTGAT TCTAGGGGAA CTTCCGATCA GAAACAGCCA ATTCAGAGTG AGAGAAGAAA ACGTGACCAT GCAGTTCCTG TGGTTACCAG CCTTGCCCCT CTCTTGCCTr CTGGGAGTTA TAAAACCCAA GACTGGAAAG GAAAACCAGC ATTTGCTCAG GCAGCCTCTC TGGGAAGATG CTGCTTCTTC CTCTCCCCCT GCTGCTCTTT CTCTTGTGCT CCAGAGCTGA AGCTGGTGAG TATCAGGGTT CTTCCCTCTG AAATCTGCAG TATCAGCTCC TGAAACAAAG ATGTTTAGTC TGAAATAGCT GACTCCTAAA CAGGGTTCCA AGATCTCTCT TCAAGAGTCC CACAGAGGAA ATTCCACTT GGGATGTGTG CCACCCCACC CCCACCCCCA CCCACTGCCA TTCTCTACAG CCTAGGACAC CCCCAGGAAC AAGGAATTTC ACCTCAATTG TAGAAAAGCC CAGAGCAAGT GGAAGGAAAA GGGGTATCCC CAGGAAAACA GACATGTCCT CTTAATCTTC TGAGCATCAG GGCTACCCAT TACTTTGTGA CTCTCACT CTGTGACCAT GCTCAAGAGC TATGGAGAAA TCTAAAACAG GAACCTGGAC AGTGGGTCCT ACACAGAGAC AGAGGAGAGT GGGCCAGGGC AAGGTGGGAG TGGGAGAAGT CTGAGATGAA AACATCAGAA TGGAGCAGAG GCAAGAATGA GATTCACCT GGGAGGTTAT GGGTGGGGAA AGATACGAAA TACAGGAGAC AGGAGAGGGA AGATGGGCGG AACACAGGGT GAGAATGAGA TTCCAGGGAA GCCTAGCTCA GCTTAACCC AAITTGTCCA TTCATTGGAG AGAGTATCTA TGGCCGTGTT CAAACCCTGG GGTGCTCTGT TCCAGGGGAG ATCATCGGGG GCACAGAATG CAAGCCACAT TCCCGCCCCT ACATGGCCTA CCTGGAAATT GTAACTTCCA ACGGTCCCTC AAAAT=TGT GGTGGTTTCC TTATAAGACG GAACTTTGTG CTGACGGCTG CTCATTGTGC AGGAAGGTGA GACAACAGGG TCTATTTATC TCCAAATGGG AGATGAACAA CCAGAGTAGC ATCCAGGAAT ACACCTGCAC TGGGGACTGA AGAGGGGGTC CTGGGTCTTG TCAACTTCA GGAGAGGGAA GAC1TTGGGC TGAAAGACTT TAGTCTGTGT TTGAATAGTT CCTTGAGCCT CAGTCACTGA GCTAAGCTCC CTTCGGAGGA AAAGGAGGTC CTGTCCGAAG GTCCCTCTTG TTGCAGTAGC ACCCCTCACC CCTACCCAAC TCAAGACACA CGGCTCACTT TTCAGGGCCC CACCCAGTCT CAGGGCCACT TCCTCTATGG CCTITTCAAG AACACTGGCT CTAGTTCTCA GGGTCCTGAA CCCATCAIT TATGGGAGCA GAGAACAGGT CTACATAAGA CCCCCACTT CCCGTITTAA CTGATATCTC CTGCTTCAGG GGCTGGCCCT CATGCAGGGT TCCCTGAATT AGGAAGTGTG AACCCTGTCC CCTGAGTCCT CCCTGGCCTG TTCAGTCCCC AGCAATTCCA GGGGTCGTAG AAATTGTGTC TGTTCCTGA GAAAGCTCTT TCATGAGTTA AGCCTGAGCC CTCAAATGCC ACAAGTGGCC CATGAAAAGG GAGATGGGTA GAGTCCGGCN ACCCAGTGAC AGAGTTTAGT CCTCTITI'CT CAGAATGAGC TCACCTCAGA AGAAACCCCA AGCCATCACT GTCGCCTCCT TTCCTTCCT TCTCCTCAC AGCAGGTCTA TAACAGTCAC CCTTGGAGCC CATAACATAA CAGAGGAAGA AGACACATGG CAGAAGCTrG AGGTTATAAA GCAATTCCGT CATCCAAAAT ATAACACTTC TACTCTTCAC CACGATATCA TGTTACTAAA GGTGACAACA CCTCTCTTCT CCCITTCCAC TTCCCATTCT CCTAAGCTrC TCCTTCAGGT CCTCATTGCC CTGAAITITT CTAGGACTT GGCTATAACA TGAAGCTACT CACCCTGTCC CTCCCTGATC ACCTCCAACT GTCCAGAGCC CATTTCGAGG ACTGACAGTC CTTCATrCCC TTCACAGTTG AAGGAGAAAG CCAGCCTGAC CCTGGCTGTG GGGACACTCC CCTTCCCATC ACAATTCAAC TITGTCCCAC CTGGGAGAAT GTGCCGGGTG GCTGGCTGGG GAAGAACAGG TGTGTTGAAG CCGGGCTCAG ACACTCTGCA AGAGGTGAAG CTGAGACTCA TGGATCCCCA GGCCTGCAGC CACTTCAGAG ACTTGACCA CAATCTTCAG CTGTGTGTGG GCAATCCCAG GAAGACAAAA TCTGCATTTA AGGTGATCCT CCAACTAGGT TTCCTCTCCA AAACTCACTG TTCAGGGACC TGAATGCTCT TAGAAGGAGA TGGGGTCAGC AGGTTGTCAG TCAGGTGACA GGGTGAGCAT CACAGGAATT GCTGTCCTCC CGTGGTCCAA GACAGCOCT GACCATCCAT TCCAGTCTAC TGCACTGGGG GCATGGGGTG ACTGTGGAGA ATGTGGATGA CGGTCCCAAG AAAGGAAGAA GGGGCATCAG AACTAGATGT ATAAGTGAGG AGCTCCACCT CCTGGGTCTG ACTTTAGGTC TCACTGTGAC TCCAAGCTGG CTGGCAGACA GGAGTGGAGG ACTrCCCGGG CTCACCTTCT TCTCTCTCTC CTCCCCCTAC AGGGAGACTC TGGGGGCCCT CTTCTGTGTG CTGGGGTGGC CCAGGGCATC GTATCCTATG GACGGTCGGA TGCAAAGCCC CCTGCTGTCT TCACCCGAAT CTCCCATTAC CGGCCCTGGA TCAACCAGAT CCTGCAGGCA AATTAATCCT GGATCCTGAG CCAGCCTGAA GGGAAGCTGG AACTGGACCT TAGCAGCAAA GTGTGTGCAA CTCATTCTGG TTCTACCCTT GGTTCCCTCA GCCACAACCC TAAGCCTCCA AGAGGTCTCC TACAGGTAAC AGAACTTCA ATAAACTTCA GTGAAGACAC AGCTTCTAGT CGTGAGTGTG TGTCCCTCTC TGCTGCTCTC TTCTCCTGCA CATGTGACCT GATTCCCAGC CCAAGCACCA AGGA-3' (FRAG. NO:) (SEQ. ID NO:2467) 5 -GGBGCBCBBG-3' (FRAG. NO:1888) (SEQ. ID NO:1899) 5-GBBGCBGC-3' (FRAG. NO:1889) (SEQ. ID NO:1900) 5-GGGGCBBGG CG-3' (FRAG. NO:1890) (SEQ. ID NO:1901) 5-CGT=TTCTTCTCTC-3' (FRAG. NO:1369)(SEQ. ID NO:1379) 5-GCTGGTTCCTTTCC-3' (FRAG. NO:1370)(SEQ. ID NO:1380) WO 00/09525 PCT/US99/17712 EPI-109 211 5'-TGGCAGTGGGTGGGGGTGGGGGTGGGGTGGC-3' (FRAG. NO:1371)(SEQ. ID NO:1381) 5'-TTrCCTTGTTCCTGGGGGTGTCCT-3' (FRAG. NO:1372)(SEQ. ID NO:1382) 5'-CTGCTCTGGGCTITrCT-3' (FRAG. NO:1373)(SEQ. ID NO:1383) 5'-CCCCTTTTCCTTCC-3' (FRAG. NO:1374)(SEQ. ID NO:1384) 5'-TGTCTGTTTCCTGGGG-3' (FRAG. NO:1375)(SEQ. ID NO: 1385) 5'-CTCTCCTCTGTCTCTGTGT-3' (FRAG. NO:1376)(SEQ. ID NO: 1386) 5'-CCTTGCCCTGGCCC-3' (FRAG. NO:1377)(SEQ. ID NO:1387) 5'-TCTrCCCTCTCCTGTCTCCTGT-3' (FRAG. NO:1378)(SEQ. ID NO:1388) 5'-CCCTGTGTTCCGCCC-3' (FRAG. NO:1379)(SEQ. ID NO: 1389) 5'-GTCTTCCCTCTCCTG-3' (FRAG. NO:1380)(SEQ. ID NO:1390) 5'-ACCTCCTI iCCTCCG-3' (FRAG. NO:1381)(SEQ. ID NO:1391) 5'-CTGGGTGGGGCCCTG-3' (FRAG. NO:1382)(SEQ. ID NO:1392) 5'-CCTGTTrCTCTGCTCCC-3' (FRAG. NO:1383)(SEQ. ID NO:1393) 5'-TGGCTFGGGGTCTTCTG-3' (FRAG. NO:1384)(SEQ. ID NO:1394) 5'-TGTGTCTrCTTCCTCTGTT-3' (FRAG. NO:1385)(SEQ. ID NO:1395) 5'-GGCTGGCTTTCTCCTTC-3' (FRAG. NO:1386)(SEQ. ID NO: 1396) 5'-TTTGTCTTCCTGGG-3' (FRAG. NO:1387)(SEQ. ID NO:1397) 5'-TGCCCCTTCTTCCTTTCTTGGG-3' (FRAG. NO:1388)(SEQ. ID NO:1398) 5'-TCCT7GGTGCTTGGGCTGGG-3' (FRAG. NO:1389)(SEQ. ID NO:1399) 5'-GGBGCTGBTB CTGCBGATTT CBGBGGGBBG BBCCCTGBTB CTCBCCBGCT TCBGCTCTGG BGCBCBBGBG BBBGBGCBGC BGGGGGBGBG GBBGBBGCBG CBTCTTCCCB GBGBGGCTGC CTGBGCBBBT GCTGGT1TC CTTTCCBGTC TTGGGTTB TBBCTCCCBG BBGGCBBGBG BGGGGCBBGG-3' (FRAG. NO:1891) (SEQ. ID NO:1902) Endothelial Nitric Oxide Svnthase Nucleic Acids and Antisense Oligonucleotide Fragments 5'-GCGTCTTGGG GTGCBGGGCC CBTCCTGCTG CGCCTGGGCG CTGCTGTGCG TCCGTCTGCT GGGGGGCCGG GGTGGCTGGG CCCTGCTT'GC CGCACGACCC CGGGCCGACC CGAGGCTCGG GGGGCTGTGT TCTGGCGCTG GTGGGCTTGG GCCCCTCTGG GGGCrGGGTr TCCTGCTGCG CCTGGGCGCT GGCGTCTTGG GGTGCGGGGC CGGGGGGCCG GGGGGCCGCT GTrCGTGGGC CTGGGGGTGC CTGTGGCTGC CGGTTGCCCC GGTTGGTGGC GCCGTCCTGC TGCCGGTCGT TGGCTGGGTC CCCCCGCCCG ITTCCTGGGG TCCGCGTGGG GTGCTCCGGT TCCTCGTGCC GCTGCTGCCT TGTCITCCG GCCGTGGCGG CGTGGTGGTC CGCCCCCCCT GGCCTTCTGC TCGGGGTCTG GCTGGTTGCC GGTGCCCTTG GCGGCGGTCT TCTTCCTGGT GGCTCTGGGC CCGGCCGGTC TCGGGCGTCT CGTGTTCGCT CTTGTGCTGT TCCGGCCGCT CCTTCCTCrr CCGCCGCCGC CGCTCCCCGC CCGCTCGTCG CCCTGGCCCG GCCTCCTCCT GGCCGCTGTC TCGGGCGGCG GCCTTGGCGC TCCGTITGGG GCTGCCTCTG GCGCTTCCGG CCCTCGGCCT GGGCGCTCTC TTCCGCCTGT GCTGGTGGCC CTCGTGGGCC CCTCCTGGCC TCCGGTGTCC TGTGGTCCCC CGGCTGGTGG CCGGGCCGGT TGGGCGGGCG TGGGCGCCGG CGGGTCCTCC GGGCTGCCCT TCTCCGCCGG GGGTCCCGCG CTCCTGCTGT TCCCTGGGCT CTTCTGCCTC TCTCCTGGGT GGGTGCTGGG TGCCGGGGTC TCCGGGCTTG CCCCGCGCTG CrGGGCGTrC TGCGGTCTTG GGGTTGTCTG TGGCCCCGCT CGTGTCGCCC TCCGTCGCCC GTCGCCGGCC TCGTCCCCTC CTGGGTGCGC GGCGGGCTGG TCCTGGCGTT TTGCTCCTTC CTGGGCGTCT TGGGGTGCBG GGCCCBTCCT GCTGCGCCTG GGCGCTGCTG TGCGTCCGTC TGCTGGGGGG CCGGGGTGGC TGGGCCCTGC TTGCCGCACG ACCCCGGGCC GACCCGAGGC TCGGGGGGCT GTGTTCTGGC GCTGGTGGGC TTGGGCCCCT CTGGGGGCTG GGTTCCTGC TGCGCCTGGG CGCTGGCGTC TTGGGGTGCG GGGCCGGGGG GCCGGGGGGC CGCTGTTCGT GGGCCTGGGG GTGCCTGTGG CTGCCGGTTG CCCCGGTTGG TGGCGCCGTC CTGCTGCCGG TCGTTGGCTG GGTCCCCCCG CCCGTTTCCT GGGGTCCGCG TGGGGTGCTC CGGTTCCTCG TGCCGCTGCT GCCTTGTCTT TCCGGCCGTG GCGGCGTGGT GGTCCGCCCC CCCTGGCCTT CTGCTCGGGG TCTGGCTGGT TGCCGGTGCC CTTGGCGGCG GTCTTCTTCC TGGTGGCTCT GGGCCCGGCC GGTCTCGGGC GTCTCGTGTT CGCTCTTGTG CTGTTCCGGC CGCTCCTTCC TCTTCCGCCG CCGCCGCTCC CCGCCCGCTC GTCGCCCTGG CCCGGCCTCC TCCTGGCCGC TGTCTCGGGC GGCGGCCTTG GCGCTCCGTT TGGGGCTGCC TCTGGCGCTT CCGGCCCTCG GCCTGGGCGC TCTCTTCCGC CTGTGCTGGT GGCCCTCGTG GGCCCCTCCT GGCCTCCGGT GTCCTGTGGT CCCCCGGCTG GTGGCCGGGC CGGTTGGGCG GGCGTGGGCG CCGGCGGGTC CTCCGGGCTG CCCTTCTCCG CCGGGGGTCC CGCGCTCCTG CTGTTCCCTG GGCTCTTCTG CCTCTCTCCT GGGTGGGTGC TGGGTGCCGG GGTCTCCGGG CTTGCCCCGC GCTGCTGGGC GTTCTGCGGT CTTGGGGTTG TCTGTGGCCC CGCTCGTGTC GCCCTCCGTC GCCCGTCGCC GGCCTCGTCC CCTCCTGGGT GCGCGGCGGG CTGGTCCTGG CGTTTGCTC CTrTCCTGG-3' (FRAG. NO:1892) (SEQ. ID NO: 1903) 5'-GCGGGGCCG-3' (FRAG. NO:1893) (SEQ. ID NO: 1904) 5'-CGGGGGGC-3' (FRAG. NO:1894) (SEQ. ID NO: 1905) 5'-GCGCGGCGGGC-3' (FRAG. NO:1895) (SEQ. ID NO: 1906) 5'-CTGTGCGTCCGTCTGCTGG (FRAG. NO:1390)(SEQ. ID NO:1400) GGGGCCGGGGTGGCTGGGCCCTGCTTGCCGC (FRAG. NO: 1391)(SEQ. ID NO: 1401) ACGACCCCGGGCCGACCCGAG (FRAG. NO: 1392)(SEQ. ID NO: 1402) GCTCGGGGGGCTGTGTTCTGGCGCTGGTGGG (FRAG. NO:1393)(SEQ. ID NO: 1403) CTTGGGCCCCTCTGGGGGCTGGGTT (FRAG. NO:1394)(SEQ. ID NO: 1404) TCCTGCTGCGCCrGGGCGCTG (FRAG. NO:1395)(SEQ. ID NO: 1405) GCGTCTTGGGGTGC (FRAG. NO:1396)(SEQ. ID NO: 1406) GGGGCCGGGGGGCCGGGGG (FRAG. NO:1397)(SEQ. ID NO: 1407) GCCGCTGTTCGTGGGCCTGGG (FRAG. NO:1398)(SEQ. ID NO:1408) GGTGCCTGTGGCTGCC (FRAG. NO:1399)(SEQ. ID NO:1409) GGTTGCCCCGGTTGGTGGC (FRAG. NO: 1400)(SEQ. ID NO: 1410) GCCGTCCTGCTGCCGGT (FRAG. NO: 1401)(SEQ. ID NO: 1411) CGTTGGCTGGGTCCCCCCGC (FRAG. NO:1402)(SEQ. ID NO:1412) CCGTTTCCTGGGGTCC (FRAG. NO:1403)(SEQ. ID NO: 1413) GCGTGGGGTGCTCC FRAGG. NO: 1404)(SEQ. ID NO: 1414) GGTTCCTCGTGCCG (FRAG. NO:1405)(SEQ. ID NO: 1415) CTGCTGCCTrGTCITCC (FRAG. NO:1406)(SEQ. ID NO:1416) WO 00/09525 PCT/US99/17712 EPI-109 212 GGCCGTGGCGGCGTGGTGGTCC (FRAG. NO: 1407)(SEQ. ID NO:1417) GCCCCCCCTGGCCTTCTGCTC (FRAG. NO: 1408)(SEQ. ID NO:1418) GGGGTCTGGCTGGT (FRAG. NO:1409)(SEQ. ID NO:1419) TGCCGGTGCCCTTGGCGGC (FRAG. NO:1410)(SEQ. ID NO:1420) GGTCTTCICCTGGTG (FRAG. NO: 1411)(SEQ. ID NO: 1421) GCTCTGGGCCCGGCCGGTCTCGG (FRAG. NO: 1412)(SEQ. ID NO: 1422) GCGTCTCGTGTTCG (FRAG. NO: 1413)(SEQ. ID NO:1423) CTCTTGTGCTGTTCCGGCCG (FRAG. NO: 1414)(SEQ. ID NO: 1424) CTCCTTCCTCTCCGCCGCC (FRAG. NO: 1415)(SEQ. ID NO: 1425) GCCGCTCCCCGCCC (FRAG. NO: 1416)(SEQ. ID NO: 1426) GCTCGTCGCCCTGGCCC (FRAG. NO: 1417)(SEQ. ID NO: 1427) GGCCTCCTCCTGGCCGC (FRAG. NO: 1418)(SEQ. ID NO:1428) TGTCTCGGGCGGCGGCCTTGGC (FRAG. NO:1419)(SEQ. ID NO: 1429) GCTCCGTITGGGGCTG (FRAG. NO:1420)(SEQ. ID NO: 1430) CCTCTGGCGCTTCC (FRAG. NO:1421)(SEQ. ID NO:1431) GGCCCTCGGCCTGGGCGCTC (FRAG. NO:1422)(SEQ. ID NO:1432) TCTTCCGCCTGTGC (FRAG. NO:1423)(SEQ. ID NO:1433) TGGTGGCCCTCGTGG (FRAG. NO: 1424)(SEQ. ID NO: 1434) GCCCCTCCTGGCCTCCGGTGTCC (FRAG. NO:1425)(SEQ. ID NO: 1435) TGTGGTCCCCCGGCTGGT (FRAG. NO:1426)(SEQ. ID NO: 1436) GGCCGGGCCGGT7GGGCGGGC (FRAG. NO:1427)(SEQ. ID NO: 1437) GTGGGCGCCGGCGGGTCCTCC (FRAG. NO:1428)(SEQ. ID NO: 1438) GGGCTGCCCTTCTCC (FRAG. NO:1429)(SEQ. ID NO: 1439) GCCGGGGGTCCCGC (FRAG. NO: 1430)(SEQ. ID NO: 1440) GCTCCTGCTGTTCCCTGGGCTCTTCTGCC (FRAG. NO:143 1)(SEQ. ID NO: 1441) TCTCTCCTGGGTGGGTGCTGGGTGCCG (FRAG. NO:1432)(SEQ. ID NO: 1442) GGGTCTCCGGGCTTG FRAGG. NO:1433)(SEQ. ID NO: 1443) CCCCGCGCTGCTGGGCGTTCTGC (FRAG. NO:1434)(SEQ. ID NO: 1444) GGTCTTGGGGTTGTC (FRAG. NO: 1435)(SEQ. ID NO: 1445) TGTGGCCCCGCTCG (FRAG. NO:1436)(SEQ. ID NO: 1446) TGTCGCCCTCCGTCGCC (FRAG. NO: 1437)(SEQ. ID NO: 1447) CGTCGCCGGCCTCGTCC (FRAG. NO: 1438)(SEQ. ID NO: 1448) CCTCCTGGGTGCGC (FRAG. NO: 1439)(SEQ. ID NO: 1449) GGCGGGCTGGTCCT (FRAG. NO: 1440)(SEQ. ID NO: 1450) GGCGTTTTGCTCCTTCCTGG (FRAG. NO: 1441)(SEQ. ID NO: 1451) 5'-GCGTCTTGGGGTGCBGGGCCCBTCCTGCTGCGCCTGGGCGCTG-3' (FRAG. NO:1896) (SEQ. ID NO: 1907) Inducible Nitric Oxide Svnthase Nucleic Acids and Antisense Oligonucleotide Fragments 5'-CTGCCCCBGT TTTTGBTCCT CBCBTGCCGT GGGGBGGBCB BTGGCTGCCT CCCCGGGGTT TCTGCTGCTT GCTGCTTCTT TCCCGTCTCC CTTCTTTCCC GTCTCCTITT TGCCTCTTTG GGTTCCTGTT GTTTCTGGCC TGCTTGGTGG CGGCTTGTGC GTTCCTCTC TCTTCTTG GGTCTCCGCT TCTCGTCCTG CC'iITrCCTG TCTCTGTCGC GCCGTTCCTC CTCCGGCGTC CTCCTGCCCT GTGCTGTTTG CCTCGGGTGG TGCGGGTCCC GGTGCTCCCC CGGCGGGCCG GCTGGTTGCC TGGGCCTGTC TGGTGGGGTG TGGGGCCGCT GGGT7GGGGG TGTGGTGGGC TCTTCTGTGG CCTGTGGGGC TGTrGGTGTC TCTGTGGGCG TGTGCTGGGT CTTGGGGCTT CCTCCCTTGT GCTGGGTGCG GCCTCCCCGC CCCCCTTCTG GGCCGGTGGC CTGGCTCCTT GTGGGCGCTT CTGGCTCTTG CCCTGTCCTT CTTCGCCTCG TGGCTGCTGG GCTGC CATATGTATG GGAATACTGT AITCAGGCA TTATAAGGAA TGAAATrATA GGCCGGGCAT TGTGGCTAAC CC TGTAATC CTAGCACTIT GAGAGGCTGA AGTGGGCAGA TCACTTGAGC TTCAGAGTTC GAGACCAGCA TGGACAACAT GGTGAAACCC AGTCTCTACC AAAAACACAA AAATATTAGC TGGGTGTGGT GGTGCATGCC TGTAGTCCCA GCTACTCAGG AGGCTGAGGT GGGAGGATCG CTTGAGCCTG GGAGGCAGAA GTFGCAATGA GCAGAGATCG TGCCACTCCG CTCCAGTCTT GGTGACAGAA TGAGACTCCA TCTCAAAAAT AAATAAATAA ATAAATAAAA TAAATGAAAT GAAATTATAA GAAATTACCA CTITITCATG TAAGAAGTGA TCATTrCCAT TATAAGGGAA GGAATITAAT CCTACCTGCC ATTCCACCAA AGCTrACCTA GTGCTAAAGG ATGAGGTGTT AGTAAGACCA ACATCTCAGA GGCCTCTCTG TGCCAATAGC CTTCCTrCCT TrCCCTTCCA AAAACCTCAA GTGACTAGTT CAGAGGCCTG TCTGGAATAA TGGCATCATC TAATATCACT GGCCTrCTGG AACCTGGGCA TITCCAGTG TGTrCCATAC TGTCAATATr CCCCCAGCTr CCTGGACTCC TGTCACAAGC TGGAAAAGTG AGAGGATGGA CAGGGATTAA CCAGAGAGCT CCCTGCTGAG GAAAAAATCT CCCAGATGCT GAAAGTGAGG CCATGTGGCT TGGCCAAATA AAACCTGGCT CCGTGGTGCC TCTGTCTrAG CAGCCACCCT GCTGATGAAC TGCCACCTTG GACTrGGGAC CAGAAAGAGG TGGGTTGGGT GAAGAGGCAC CACACAGAGT GATGTAACAG CAAGATCAGG TCACCCACAG GCCCTGGCAG TCACAGTCAT AAATrAGCTA ACTGTACACA AGCTGGGGAC ACTCCCITG GAAACCAAAA AAAAAAAAAA AAAAAAGAGA CCTTTATGCA AAAACAACTC TCTGGATGGC ATGGGGTGAG TATAAATACT TCTTGGCTGC CAGTGTGTTC ATAACITGT AGCGAGTCGA AAACTGAGGC TCCGGCCGCA GAGAACTCAG CCTCATTCCT GCTITAAAAT CTCTCGGCCA CCITGATGA GGGGACTGGG CAGTTCTAGA CAGTCCCGAA GTTCTCAAGG CACAGGTCTC T7CCTGGTT GACTGTCCTr ACCCCGGGGA GGCAGTGCAG CCAGCTGCAA GGTGAGTGC C CATATGTATG GGAATACTGT ATITCAGGCA TTATAAGGAA TGAAATATA GGCCGGGCAT TGTGGCTAAC CCTrGTAATC CTAGCACIT GAGAGGCTGA AGTGGGCAGA TCACTTGAGC TFCAGAGTTC GAGACCAGCA TGGACAACAT GGTGAAACCC AGTCTCTACC AAAAACACAA AAATATTAGC TGGGTGTGGT GGTGCATGCC TGTAGTCCCA GCTACTCAGG AGGCTGAGGT GGGAGGATCG CTTGAGCCTG GGAGGCAGAA GT'GCAATGA GCAGAGATCG TGCCACTCCG CTCCAGTCTT GGTGACAGAA TGAGACTCCA TCTCAAAAAT AAATAAATAA ATAAATAAAA TAAATGAAAT GAAATrATAA GAAATTACCA CTITTCATG TAAGAAGTGA TCATITCCAT TATAAGGGAA GGAATTTAAT CCTACCTGCC ATrCCACCAA AGCTTACCTA GTGCTAAAGG WO 00/09525 PCT/US99/17712 EPI-109 213 ATGAGGTGTT AGTAAGACCA ACATCTCAGA GGCCTCTCTG TGCCAATAGC CITCCTTCCT TTCCCTTCCA AAAACCTCAA GTGACTAGTT CAGAGGCCTG TCTGGAATAA TGGCATCATC TAATATCACT GGCCTTCTGG AACCTGGGCA TITCCAGTG TGTTCCATAC TGTCAATATT CCCCCAGCTT CCTGGACTCC TGTCACAAGC TGGAAAAGTG AGAGGATGGA CAGGGATFAA CCAGAGAGCT CCCTGCTGAG GAAAAAATCT CCCAGATGCT GAAAGTGAGG CCATGTGGCT TGGCCAAATA AAACCTGGCT CCGTGGTGCC TCTGTCTTAG CAGCCACCCT GCTGATGAAC TGCCACCTTG GACTTGGGAC CAGAAAGAGG TGGGTTGGGT GAAGAGGCAC CACACAGAGT GATGTAACAG CAAGATCAGG TCACCCACAG GCCCTGGCAG TCACAGTCAT AAATTAGCTA ACTGTACACA AGCTGGGGAC ACTCCCTTTG GAAACCAAAA AAAAAAAAAA AAAAAAGAGA CCTTTATGCA AAAACAACTC TCTGGATGGC ATGGGGTGAG TATAAATACT TCTTGGCTGC CAGTGTGTTC ATAACTTTGT AGCGAGTCGA AAACTGAGGC TCCGGCCGCA GAGAACTCAG CCTCATTCCT GCTrAAAAT CTCTCGGCCA CCTITGATGA GGGGACTGGG CAGTTCTAGA CAGTCCCGAA GTTCTCAAGG CACAGGTCTC TTCCTGGT GACTGTCCTT ACCCCGGGGA GGCAGTGCAG CCAGCTGCAA GGTGAGTTGC C-3' (FRAG. NO:_)(SEQ. ID NO: 2506) 5'-CTGCTTAAA ATCTCTCGGC CACCITTGAT GAGGGGACTG GGCAGTTCTA GACAGTCCCG AAGTTCTCAA GGCACAGGTC TCTTCCTGGT TTGACTGTCC TTACCCCGGG GAGGCAGTGC AGCCAGCTGC AAGCCCCACA GTGAAGAACA TCTGAGCTCA AATCCAGATA AGTGACATAA GTGACCTGCT TTGTAAAGCC ATAGAGATGG CCTGTCCTTG GAAATTTCTG TTCAAGACCA AATTCCACCA GTATGCAATG AATGGGGAAA AAGACATCAA CAACAATGTG GAGAAAGCCC CCTGTGCCAC CTCCAGTCCA GTGACACAGG ATGACCTTCA GTATCACAAC CTCAGCAAGC AGCAGAATGA GTCCCCGCAG CCCCTCGTGG AGACGGGAAA GAAGTCTCCA GAATCTCTGG TCAAGCTGGA TGCAACCCCA TTGTCCTCCC CACGGCATGT GAGGATCAAA AACTGGGGCA GCGGGATGAC TTTCCAAGAC ACACTTCACC ATAAGGCCAA AGGGATITA ACTTGCAGGT CCAAATCTTG CCTGGGGTCC ATTATGACTC CCAAAAGTTT GACCAGAGGA CCCAGGGACA AGCCTACCCC TCCAGATGAG CTTCTACCTC AAGCTATCGA A'TTGTCAAC CAATATTACG GCTCCTTCAA AGAGGCAAAA ATAGAGGAAC ATCTGGCCAG GGTGGAAGCG GTAACAAAGG AGATAGAAAC AACAGGAACC TACCAACTGA CGGGAGATGA GCTCATC=TC GCCACCAAGC AGGCCTGGCG CAATGCCCCA CGCTGCATTG GGAGGATCCA GTGGTCCAAC CTGCAGGTCT TCGATGCCCG CAGCTGTTCC ACTGCCCGGG AAATGTTT'GA ACACATCTGC AGACACGTGC GTTACTCCAC CAACAATGGC AACATCAGGT CGGCCATCAC CGTGTTCCCC CAGCGGAGTG ATGGCAAGCA CGACTTCCGG GTGTGGAATG CTCAGCTCAT CCGCTATGCT GGCTACCAGA TGCCAGATGG CAGCATCAGA GGGGACCCTG CCAACGTGGA ATTCACTCAG CTGTGCATCG ACCTGGGCTG GAAGCCCAAG TACGGCCGCT TCGATGTGGT CCCCCTGGTC CTGCAGGCCA ATGGCCGTGA CCCTGAGCTC TTCGAAATCC CACCTGACCT TGTGCTTGAG GTGGCCATGG AACATCCCAA ATACGAGTGG TTTCGGGAAC TGGAGCTAAA GTGGTACGCC CTGCCTGCAG TGGCCAACAT GCTGCTTGAG GTGGGCGGCC TGGAGTTCCC AGGGTGCCCC TrCAATGGCT GGTACATGGG CACAGAGATC GGAGTCCGGG ACTTCTGTGA CGTCCAGCGC TACAACATCC TGGAGGAAGT GGGCAGGAGA ATGGGCCTGG AAACGCACAA GCTGGCCTCG CTCTGGAAAG ACCAGGCTGT CGTTGAGATC AACATTGCTG TGATCCATAG TTITCAGAAG CAGAATGTGA CCATCATGGA CCACCACTCG GCTGCAGAAT CCTTCATGAA GTACATGCAG AATGAATACC GGTCCCGTGG GGGCTGCCCG GCAGACTGGA TTTGGCTGGT CCCTCCCATG TCTGGGAGCA TCACCCCCGT GTCACCAG GAGATGCTGA ACTACGTCCT GTCCCCITC TACTACTATC AGGTAGAGGC CTGGAAAACC CATGTCTGGC AGGACGAGAA GCGGAGACCC AAGAGAAGAG AGATTCCATT GAAAGTCTTG GTCAAAGCTG TGCT7CTITGC CTGTATGCTG ATGCGCAAGA CAATGGCGTC CCGAGTCAGA GTCACCATCC TCTTGCGAC AGAGACAGGA AAATCAGAGG CGCTGGCCTG GGACCTGGGG GCCTTATTCA GCTGTGCCTT CAACCCCAAG GTTGTCTGCA TGGATAAGTA CAGGCTGAGC TGCCTGGAGG AGGAACGGCT GCTGTrGGTG GTGACCAGTA CGTTTGGCAA TGGAGACTGC CCTGGCAATG GAGAGAAACT GAAGAAATCG CTCTTCATGC TGAAAGAGCT CAACAACAAA TTCAGGTACG CTGTGT1TTGG CCTCGGCTCC AGCATGTACC CTCGGTTCTG CGCCTTGCT CATGACATTG ATCAGAAGCT GTCCCACCTG GGGGCCTCTC AGCTCACCCC GATGGGAGAA GGGGATGAGC TCAGTGGGCA GGAGGACGCC TTCCGCAGCT GGGCCGTGCA AACCTTCAAG GCAGCCTGTG AGACGTTTGA TGTCCGAGGC AAACAGCACA TTCAGATCCC CAAGCTCTAC ACCTCCAATG TGACCTGGGA CCCGCACCAC TACAGGCTCG TGCAGGACTC ACAGCCTTG GACCTCAGCA AAGCCCTCAG CAGCATGCAT GCCAAGAACG TGTTCACCAT GAGGCTCAAA TCTCGGCAGA ATCTACAAAG TCCGACATCC AGCCGTGCCA CCATCCTGGT GGAACTCTCC TGTGAGGATG GCCAAGGCCT GAACTACCTG CCGGGGGAGC ACCTTGGGGT TTGCCCAGGC AACCAGCCGG CCCTGGTCCA AGGCATCCTG GAGCGAGTGG TGGATGGCCC CACACCCCAC CAGACAGTGC GCCTGGAGGA CCTGGATGAG AGTGGCAGCT ACTGGGTCAG TGACAAGAGG CTGCCCCCCT GCTCACTCAG CCAGGCCCTC ACCTACTCCC CGGACATCAC CACACCCCCA ACCCAGCTGC TGCTCCAAAA GCTGGCCCAG GTGGCCACAG AAGAGCCTGA GAGACAGAGG CTGGAGGCCC TGTGCCAGCC CTCAGAGTAC AGCAAGTGGA AGTTCACCAA CAGCCCCACA TTCCTGGAGG TGCTAGAGGA GTTCCCGTCC CTGCGGGTGT CTGCTGGCTT CCTGCTCC CAGCTCCCCA TTCTGAAGCC CAGGTTCTAC TCCATCAGCT CCTCCCGGGA TCACACGCCC ACGGAGATCC ACCTGACTGT GGCCGTGGTC ACCTACCACA CCGGAGATGG CCAGGGTCCC CTGCACCACG GTGTCTGCAG CACATGGCTC AACAGCCTGA AGCCCCAAGA CCCAGTGCCC TGCTTTGTGC GGAATGCCAG CGCCTTCCAC CTCCCCGAGG ATCCCTCCCA TCCTTGCATC CTCATCGGGC CTGGCACAGG CATCGTGCCC TTCCGCAGTT TCTGGCAGCA ACGGCTCCAT GACTCCCAGC ACAAGGGAGT GCGGGGAGGC CGCATGACCT TGGTGTTTGG GTGCCGCCGC CCAGATGAGG ACCACATCTA CCAGGAGGAG ATGCTGGAGA TGGCCCAGAA GGGGGTGCTG CATGCGGTGC ACACAGCCTA TTCCCGCCTG CCTGGCAAGC CCAAGGTCTA TGTTCAGGAC ATCCTGCGGC AGCAGCTGGC CAGCGAGGTG CTCCGTGTGC TCCACAAGGA GCCAGGCCAC CTCTATGTTT GCGGGGATGT GCGCATGGCC CGGGACGTGG CCCACACCCT GAAGCAGCTG GTGGCTGCCA AGCTGAAATT GAATGAGGAG CAGGTCGAGG ACTATTTCIT TCAGCTCAAG AGCCAGAAGC GCTATCACGA AGATATCTITC GGTGCTGTAT TTCCTACGA GGCGAAGAAG GACAGGGTGG CGGTGCAGCC CAGCAGCCTG GAGATGTCAG CGCTCTGAGG GCCTACAGGA GGGGTTAAAG CTGCCGGCAC AGAACT7AAG GATGGAGCCA GCTCTGCATT ATCTGAGGTC ACAGGGCCTG GGGAGATGGA GGAAAGTGAT ATCCCCCAGC CTCAAGTCTT ATTrCCTCAA CGTTGCTCCC CATCAAGCCC TACTTGAC CTCCTAACAA GTAGCACCCT GGATTGATCG GAGCCTCCTC TCTCAAACTG GGGCCTCCCT GGTCCCI TGG AGACAAAATC TTAAATGCCA GGCCTGGCGA GTGGGTGAAA GATGGAACTT GCTGCTGAGT GCACCACTTC AAGTGACCAC CAGGAGGTGC TATCGCACCA CTGTGTA'TT AACTGCCTTG TGTACAGTTA TATGCCTC TGTA'TTAAA AAACTAACAC CCAGTCTGT7 CCCCATGGCC ACTTGGGTCT TCCCTGTATG ATTCCTTGAT GGAGATATTT ACATGAATrG CATTACT TAATC GAATTCCCAC TCTGCTGCCT GCTCCAGCAG ACGGACGCAC AGTAACATGG GCAACTGAA GAGCGTGGCC CAGGAGCCTG GGCCACCCTG CGGCCTGGGG CTGGGGCTGG GCC=TGGGCT GTGCGGCAAG CAGGGCCCAG CCACCCCGGC CCCTGAGCCC AGCCGGGCCC CAGCATCCCT ACTCCCACCA GCGCCAGAAC ACAGCCCCCC GAGCTCCCCG CTAACCCAGC CCCCAGAGGG GCCCAAGTTC CCTCGTGTGA AGAACTGGGA GGTGGGGAGC ATCACCTATG ACACCCTCAG CGCCCAGGCG CAGCAGGATG GGCCCTGCAC CCCAAGACGC TGCCTGGGCT CCCTGGTATr TCCACGGAAA CTACAGGGCC GGCCCTCCCC CGGCCCCCCG GCCCCTGAGC WO 00/09525 PCT/US99/17712 EPI-109 214 AGCTGCTGAG TCAGGCCCGG GACTrCATCA ACCAGTACTA CAGCTCCATT AAGAGGAGCG GCTCCCAGGC CCACGAACAG CGGCITCAAG AGGTGGAAGC CGAGGTGGCA GCCACAGGCA CCTACCAGCT TAGGGAGAGC GAGCTGGTGT TCGGGGCTAA GCAGGCCTGG CGCAACGCTC CCCGCTGCGT GGGCCGGATC CAGTGGGGGA AGCTGCAGGT GTTCGATGCC CGGGACTGCA GGTCTGCACA GGAAATGTTC ACCTACATCT GCAACCACAT CAAGTATGCC ACCAACCGGG GCAACCTrCG CTCGGCCATC ACAGTGTTCC CGCAGCGCTG CCCTGGCCGA GGAGACTTCC GAATCTGGAA CAGCCAGCTG GTGCGCTACG CGGGCTACCG GCAGCAGGAC GGCTCTGTGC GGGGGGACCC AGCCAACGTG GAGATCACCG AGCTCTGCAT TCAGCACGGC TGGACCCCAG GAAACGGTCG CFTCGACGTG CTGCCCCTGC TGCTGCAGGC CCCAGATGAG CCCCCAGAAC TCTTCCTTCT GCCCCCCGAG CTGGTCCTTG AGGTGCCCCT GGAGCACCCC ACGCTGGAGT GGTGCAGC CCTGGGCCTG CGCTGGTACG CCCTCCCGGC AGTGTCCAAC ATGCTGCTGG AAATTGGGGG CCTGGAGTTC CCCGCAGCCC CCTTCAGTGG CTGGTACATG AGCACTGAGA TCGGCACGAG GAACCTGTGT GACCCTCACC GCTACAACAT CCTGGAGGAT GTGGCTGTCT GCATGGACCT GGATACCCGG ACCACCTCGT CCCTGTGGAA AGACAAGGCA GCAGTGGAAA TCAACGTGGC CGTGCTGCAC AGTTACCAGC TAGCCAAAGT CACCATCGTG GACCACCACG CCGCCACGGC CTCTTCATG AAGCACCTGG AGAATGAGCA GAAGGCCAGG GGGGGCTGCC CTGCAGACTG GGCCTGGATC GTGCCCCCCA TCTCGGGCAG CCTCACTCCT GTTCCATC AGGAGATGGT CAACTATTTC CTGTCCCCGG CCTrCCGCTA CCAGCCAGAC CCCTGGAAGG GGAGTGCCGC CAAGGGCACC GGCATCACCA GGAAGAAGAC CTTTAAAGAA GTGGCCAACG CCGTGAAGAT CTCCGCCTCG CTCATGGGCA CGGTGATGGC GAAGCGAGTG AAGGCGACAA TCCTGTATGG CTCCGAGACC GGCCGGGCCC AGAGCTACGC ACAGCAGCTG GGGAGACTCT TCCGGAAGGC TTTGATCCC CGGGTCCTGT GTATGGATGA GTATGACGTG GTGTCCCTCG AACACGAGAC GCTGGTGCTG GTGGTAACCA GCACATI7GG GAATGGGGAT CCCCCGGAGA ATGGAGAGAG CTTGCAGCT GCCCTGATGG AGATGTCCGG CCCCTACAAC AGCTCCCCTC GGCCGGAACA GCACAAGAGT TATAAGATCC GCTTCAACAG CATCTCCTGC TCAGACCCAC TGGTGTCCTC TTGGCGGCGG AAGAGGAAGG AGTCCAGTAA CACAGACAGT GCAGGGGCCC TGGGCACCCT CAGGTTCTGT GTGTTCGGGC TCGGCTCCCG GGCATACCCC CACTTCTGCG CCTTGCTCG TGCCGTGGAC ACACGGCTGG AGGAACTGGG CGGGGAGCGG CTGCTGCAGC TGGGCCAGGG CGACGAGCTG TGCGGCCAGG AGGAGGCCTT CCGAGGCTGG GCCCAGGCTG CCTTCCAGGC CGCCTGTGAG ACC1CTGTG TGGGAGAGGA TGCCAAGGCC GCCGCCCGAG ACATCTTCAG CCCCAAACGG AGCTGGAAGC GCCAGAGGTA CCGGCTGAGC GCCCAGGCCG AGGGCCTGCA GTTGCTGCCA GGTCTGATCC ACGTGCACAG GCGGAAGATG TTCCAGGCTA CAATCCGCTC AGTGGAAAAC CTGCAAAGCA GCAAGTCCAC GAGGGCCACC ATCCTGGTGC GCCTGGACAC CGGAGGCCAG GAGGGGCTGC AGTACCAGCC GGGGGACCAC ATAGGTGTCT GCCCGCCCAA CCGGCCCGGC CTTGTGGAGG CGCTGCTGAG CCGCGTGGAG GACCCGCCGG CGCCCACTGA GCCCGTGGCA GTAGAGCAGC TGGAGAAGGG CAGCCCTGGT GGCCCTCCCC CCGGCTGGGT GCGGGACCCC CGGCTGCCCC CGTGCACGCT GCGCCAGGCT CTCACCTTCT TCCTGGACAT CACCTCCCCA CCCAGCCCTC AGCTCITGCG GCTGCTCAGC ACCTTGGCAG AAGAGCCCAG GGAACAGCAG GAGCTGGAGG CCCTCAGCCA GGATCCCCGA CGCTACGAGG AGTGGAAGTG GTTCCGCTGC CCCACGCTGC TGGAGGTGCT GGAGCAGTTC CCGTCGGTGG CGCTGCCTGC CCCACTGCTC CTCACCCAGC TGCCTCTGCT CCAGCCCCGG TACTACTCAG TCAGCTCGGC ACCCAGCACC CACCCAGGAG AGATCCACCT CACTGTAGCT GTGCTGGCAT ACAGGACTCA GGATGGGCTG GGCCCCCTGC ACTATGGAGT CTGCTCCACG TGGCTAAGCC AGCTCAAGCC CGGAGACCCT GTGCCCTGCT TCATCCGGGG GGCTCCCTCC TTCCGGCTGC CACCCGATCC CAGCTTGCCC TGCATCCTGG TGGGTCCAGG CACTGGCATT GCCCCCTTCC GGGGATTCTG GCAGGAGCGG CTGCATGACA TFGAGAGCAA AGGGCTGCAG CCCACTCCCA TGACTTTGGT GTTCGGCTGC CGATGCTCCC AACTTGACCA TCTCTACCGC GACGAGGTGC AGAACGCCCA GCAGCGCGGG GTGTITGGCC GAGTCCTCAC CGCCTTCTCC CGGGAACCTG ACAACCCCAA GACCTACGTG CAGGACATCC TGAGGACGGA GCTGGCTGCG GAGGTGCACC GCGTGCTGTG CCTCGAGCGG GGCCACATGT TTGTCTGCGG CGATGT7ACC ATGGCAACCA ACGTCCTGCA GACCGTGCAG CGCATCCTGG CGACGGAGGG CGACATGGAG CTGGACGAGG CCGGCGACGT CATCGGCGTG CTGCGGGATC AGCAACGCTA CCACGAAGAC ATTTTCGGGC TCACGCTGCG CACCCAGGAG GTGACAAGCC GCATACGCAC CCAGAGCT TCCTTGCAGG AGCGTCAGTT GCGGGGCGCA GTGCCCTGGG CGTTCGACCC TCCCGGCTCA GACACCAACA GCCCCTGAGA GCCGCCTGGC TTTCCCTrCC AGTTCCGGGA GAGCGGCTGC CCGACTCAGG TCCGCCCGAC CAGGATCAGC CCCGCTCCTC CCCTCTTGAG GTGGTGCCTT CTCACATCTG TCCAGAGGCT GCAAGGATTC AGCATTATTC CTCCAGGAAG GAGCAAAACG CCTCFTMCC CTCTCTAGGC CTGTTGCCTC GGGCCTGGGT CCGCCTTAAT CTGGAAGGCC CCTCCCAGCA GCGGTACCCC AGGGCCTACT GCCACCCGCT TCCTGTTTCT TAGTCCGAAT GTrAGATrCC TCTTGCCTCT CTCAGGAGTA TCTTACCTGT AAAGTCTAAT CTCTAAATCA AGTATTATFr ATTGAAGATT TACCATAAGG GACTGTGCCA GATGTAGGA GAACTACTAA AGTGCCTACC CCAGCTC-3' (FRAG. NO:1897) (SEQ. ID NO: 1908) 5'-CATATGTATG GGAATACTGT ATITCAGGCA TTATAAGGAA TGAAATTATA GGCCGGGCAT TGTGGCTAAC CCTTGTAATC CTAGCACT GAGAGGCTGA AGTGGGCAGA TCAC1TGAGC TrCAGAGTrC GAGACCAGCA TGGACAACAT GGTGAAACCC AGTCTCTACC AAAAACACAA AAATATTAGC TGGGTGTGGT GGTGCATGCC TGTAGTCCCA GCTACTCAGG AGGCTGAGGT GGGAGGATCG CTrGAGCCTG GGAGGCAGAA GTrGCAATGA GCAGAGATCG TGCCACTCCG CTCCAGTCTT GGTGACAGAA TGAGACTCCA TCTCAAAAAT AAATAAATAA ATAAATAAAA TAAATGAAAT GAAATTATAA GAAATrACCA CTITITCATG TAAGAAGTGA TCATTCCAT TATAAGGGAA GGAATAAT CCTACCTGCC ATrCCACCAA AGCTFACCTA GTGCTAAAGG ATGAGGTGTF AGTAAGACCA ACATCTCAGA GGCCTCTCTG TGCCAATAGC CTrCCTrCCT TrCCCTrCCA AAAACCTCAA GTGACTAGT CAGAGGCCTG TCTGGAATAA TGGCATCATC TAATATCACT GGCCTTCTGG AACCTGGGCA TITfCCAGTG TGTrCCATAC TGTCAATATT CCCCCAGCTF CCTGGACTCC TGTCACAAGC TGGAAAAGTG AGAGGATGGA CAGGGATTAA CCAGAGAGCT CCCTGCTGAG GAAAAAATCT CCCAGATGCT GAAAGTGAGG CCATGTGGCT TGGCCAAATA AAACCTGGCT CCGTGGTGCC TCTGTCTTAG CAGCCACCCT GCTGATGAAC TGCCACCTrG GACTTGGGAC CAGAAAGAGG TGGGTTGGGT GAAGAGGCAC CACACAGAGT GATGTAACAG CAAGATCAGG TCACCCACAG GCCCTGGCAG TCACAGTCAT AAATrAGCTA ACTGTACACA AGCTGGGGAC ACTCCCTITG GAAACCAAAA AAAAAAAAAA AAAAAAGAGA CCTTATGCA AAAACAACTC TCTGGATGGC ATGGGGTGAG TATAAATACT TCTTGGCTGC CAGTGTGT1C ATAACTGT AGCGAGTCGA AAACTGAGGC TCCGGCCGCA GAGAACTCAG CCTCATTCCT GCTITAAAAT CTCTCGGCCA CCMTTGATGA GGGGACTGGG CAGTrCTAGA CAGTCCCGAA GTTCTCAAGG CACAGGTCTC TrCCTGGTIT GACTGTCCTT ACCCCGGGGA GGCAGTGCAG CCAGCTGCAA GGTGAGTrGC C-3' (FRAG. NO: )(SEQ. ID NO: 2506) 5'-CTGCTTTAAA ATCTCTCGGC CACCTTGAT GAGGGGACTG GGCAGTTCTA GACAGTCCCG AAGTTCTCAA GGCACAGGTC TCTTCCTGGT TTGACTGTCC TTACCCCGGG GAGGCAGTGC AGCCAGCTGC AAGCCCCACA GTGAAGAACA TCTGAGCTCA AATCCAGATA AGTGACATAA GTGACCTGCT TTGTAAAGCC ATAGAGATGG CCTGTCCTTG GAAATTCTG TTCAAGACCA WO 00/09525 PCT/US99/1 7712 EPI-109 215 AATrCCACCA GTATGCAATG AATGGGGAAA AAGACATCAA CAACAATGTG GAGAAAGCCC CCTGTGCCAC CTCcAGTCCA GTGACACAGG ATGACCTTCA GTATCACAAC CTCAGCAAGC AGCAGAATGA GTCCCCGCAG CCCCTCGTGG AGACGGGAAA GAAGTCTCCA GAATCTCTGG TCAAGCTGGA TGCAACCCCA TTGTCCTCCC CACGGCATGT GAGGATCAAA AACTGGGGCA GCGGGATGAC ITCCAAGAC ACACrrCACC ATAAGGCCAA AGGGAlTIA ACTTGCAGGT CCAAATCT7G CCTGGGGTCC ATTATGACTC CCAAAAGTrT GACCAGAGGA CCCAGGGACA AGCCTACCCC TCCAGATGAG =TCTACCTC AAGCTATCGA A=rGTCAAC CAATATACG GCTCCTCAA AGAGGCAAAA ATAGAGGAAC ATCTGGCCAG GGTGGAAGCG GTAACAAAGG AGATAGAAAC AACAGGAACC TACCAACTGA CGGGAGATGA GCTCATCITC GCCACCAAGC AGGCCTGGCG CAATGCCCCA CGCTGCATTrG GGAGGATCCA GTGGTCCAAC CTGCAGGTCTF TCGATGCCCG CAGCTGTrCC ACTGCCCGGG AAATGn7~GA ACACATCTGC AGACACGTGC GTTACTCCAC CAACAATGGC AACATCAGGT CGGCCATCAC CGTG'TTCCCC CAGCGGAGTG ATGGCAAGCA CGAC'ICCGG GTGTGGAATG CTCAGCTCAT CCGCTATGCT GGCTACCAGA TGCCAGATGG CAGCATCAGA GGGGACCCTG CCAACGTGGA ATTCACTCAG CTGTGCATCG ACCTGGGCrG GAAGCCCAAG TACGGCCGCT TCGATGTGGT CCCCCTGGTC CTGCAGGCCA ATGGCCGTGA CCCTGAGCTC TTCGAAATCC CACCTGACCT TGTGCTrGAG GTGGCCATGG AACATCCCAA ATACGAGTGG TITCGGGAAC TGGAGCTAAA GTGGTACGCC CTGCCTGCAG TGGCCAACAT GCTGCIGAG GTGGGCGGCC TGGAGTrCCC AGGGTGCCCC TrCAATGGCT GGTACATGGG CACAGAGATC GGAGTCCGGG AC'FrCTGTGA CGTCCAGCGC TACAACATCC TGGAGGAAGT GGGCAGGAGA ATGGGCCTrGG AAACGCACAA GCTGGCCTCG CTCTGGAAAG ACCAGGCTGT CGTTGAGATC AACATrGCTG TGATCCATAG TITCAGAAG CAGAATGTGA CCATCATGGA CCACCACTCG GCTGCAGAAT CCICATGAA GTACATGCAG AATGAATACC GGTCCCGTGG GGGCTGCCCG GCAGACTGGA TTGGCTGGT CCCTCCCATG TCTGGGAGCA TCACCCCCGT G'I17CACCAG GAGATGCTGA ACTACGTCCT GTCCCC'=C TACTACTATC AGGTAGAGGC CTGGAAAACC CATGTCTGGC AGGACGAGAA GCGGAGACCC AAGAGAAGAG AGA'TCCATT GAAAGT=~G GTCAAAGCTG TGCTC'=GC CTGTATGCTG ATGCGCAAGA CAATGGCGTC CCGAGTCAGA GTCACCATCC TCTTGCGAC AGAGACAGGA AAATCAGAGG CGCTGGCCTG GGACCTGGGG GCCTrA F7CA GCTGTGCC17 CAACCCCAAG GTTGTCTGCA TGGATAAGTA CAGGCTGAGC TGCCTGGAGG AGGAACGGCT GCTGTTGGTG GTGACCAGTA CGTIrGGCAA TGGAGACTGC CCTGGCAATG GAGAGAAACT GAAGAAATCG CT=TCATGC TGAAAGAGCT CAACAACAAA TTCAGGTACG CTGTG=FGG CCTCGGCTCC AGCATGTACC CTCGGTTCTG CGCC'TGCT CATGACATTG ATCAGAAGCT GTCCCACCTG GGGGCcTrCTC AGCTCACCCC GATGGGAGAA GGGGATGAGC TCAGTGGGCA GGAGGACGCC TTCCGCAGCT GGGCCGTGCA AACC=CAAG GCAGCCTGTG AGACG=TGA TGTCCGAGGC AAACAGCACA TTCAGATCCC CAAGCTCTAC ACCTCCAATG TGACCTGGGA CCCGCACCAC TACAGGCTCG TGCAGGACTC ACAGCCTTG GACCTCAGCA AAGCCCTCAG CAGCATGCAT GCCAAGAACG TG7'TCACCAT GAGGCTCAAA TCTCGGCAGA ATCTACAAAG TCCGACATCC AGCCGTGCCA CCATCCTGGT GGAAcTCTCC TGTGAGGATG GCCAAGGCCT GAACTACCTG CCGGGGGAGC ACCTITGGGGT T7GCCCAGGC AACCAGCCGG CCCTGGTCCA AGGCATCCTG GAGCGAGTGG TGGATGGCCC CACACCCCAC CAGACAGTGC GCCTGGAGGA CCTGGATGAG AGTGGCAGCT ACTGGGTCAG TGACAAGAGG CTGCCCCCCT GCTCACTCAG CCAGGCCCTC ACCFACTCCC CGGACATCAC CACACCCCCA ACCCAGCTGC TGCTCCAAAA GCTGGCCCAG GTGGCCACAG AAGAGCCTGA GAGACAGAGG CTGGAGGCCC TGTGCCAGCC CTCAGAGTAC AGCAAGTGGA AGTrCACCAA CAGCCCCACA 7FCCTGGAGG TGCTAGAGGA G FFCCCGTCC CTGCGGGTGT CTGCTGGCT[ CCTGCInrCC CAGCTCCCCA T7CTGAAGCC CAGGTTCTAC TCCATCAGCT CCTCCCGGGA TCACACGCCC ACGGAGATCC ACCTGACTGT GGCCGTGGTC ACCTACCACA CCGGAGATGG CCAGGGTCCC CTGCACCACG GTGTCTGCAG CACATGGCTC AACAGCCTGA AGCCCCAAGA CCCAGTGCCC TG='TGTGC GGAATGCCAG CGCcTrCCAC CTCCCCGAGG ATCCCTCCCA TCCTTGCATC CTCATCGGGC CTGGCACAGG CATCGTGCCC rrCCGCAGT'T TCTGGCAGCA ACGGCTCCAT GACTCCCAGC ACAAGGGAGT GCGGGGAGGC CGCATGACCT TGGTGTrGG GTGCCGCCGC CCAGATGAGG ACCACATCTA CCAGGAGGAG ATGCTGGAGA TGGCCCAGAA GGGGGTGCTG CATGCGGTGC ACACAGCCTA T7CCCGCCTG CCTGGCAAGC CCAAGGTCTA TGTTCAGGAC ATCCrGCGGC AGCAGCTGGC CAGCGAGGTG CTCCGTGTGC TCCACAAGGA GCCAGGCCAC CTCTATGTI7 GCGGGGATGT GCGCATGGCC CGGGACGTGG CCCACACCCT GAAGCAGCTG GTGGCTGCCA AGCTGAAATr GAATGAGGAG CAGGTCGAGG ACTATrTI' TCAGCTCAAG AGCCAGAAGC GCTATCACGA AGATATCTrC GGTGCTrGTAT 'FrCcMACGA GGCGAAGAAG GACAGGGTGG CGGTGCAGCC CAGCAGCCTG GAGATGTCAG CGCTCTGAGG GCCTACAGGA GGGGT-rAAAG CTGCCGGCAC AGAA=TAAG GATGGAGCCA GCTCTGCATF[ ATCTGAGGTC ACAGGGCCTG GGGAGATGGA GGAAAGTGAT ATCCCCCAGC CTCAAGT=T ATICCTCAA CGTTGCTCCC CATCAAGCCC TIACFGAC CTCCTAACAA GTAGCACCCT GGATTGATCG GAGCCTCCTC TCTCAAACTG GGGCCTCCCT GGTCCCTTGG AGACAAAATC TTAAATGCCA GGCCTGGCGA GTGGGTGAAA GATGGAACTr GCTGCTGAGT GCACCA=TC AAGTGACCAC CAGGAGGTGC TATCGCACCA CrGTGTATFl- AACTGC=TG TGTACAGTTFA TITATGCCTC TGTATIAAA AAACTAACAC CCAGTCTGT7 CCCCATGGCC ACTTGGGTCT TCCCTGTATG AITCCTTGAT GGAGATAT77 ACATGAAT7G CA=1TA=F TAATC-3' (FRAG. NO:_)(SEQ. ID NO:2507) 5'-GAATrCCCAC TCTGCTGCCT GCTCCAGCAG ACGGACGCAC AGTAACATGG GCAACTrGAA GAGCGTGGCC CAGGAGCCTG GGCCACCCTG CGGCCTGGGG CTGGGGCTGG GCCTrGGGCT GTGCGGCAAG CAGGGCCCAG CCACCCCGGC CCCTGAGCCC AGCCGGGCCC CAGCATCCCT ACTCCCACCA GCGCCAGAAC ACAGCCCCCC GAGCTCCCCG CTAACCCAGC CCCCAGAGGG GCCCAAGTrC CCTCGTGTGA AGAACTGGGA GGTGGGGAGC ATCACCTATG ACACCCTCAG CGCCCAGGCG CAGCAGGATG GGCCCTGCAC CCCAAGACGC TGCCTGGGCT CCCTGGTATT TCCACGGAAA CTACAGGGCC GGCCCTCCCC CGGCCCCCCG GCCCCTGAGC AGCTGCTGAG TCAGGCCCGG GACTTCATCA ACCAGTACTA CAGCTCCATT AAGAGGAGCG GCTCCCAGGC CCACGAACAG CGGCTrCAAG AGGTGGAAGC CGAGGTGGCA GCCACAGGCA CCTACCAGCT TAGGGAGAGC GAGCTGGTGT TCGGGGCTAA GCAGGCCTGG CGCAACGCTC CCCGCTGCGT GGGCCGGATC CAGTGGGGGA AGCTGCAGGT GTTCGATGCC CGGGACTGCA GGTCTGCACA GGAAATGTTC ACCTACATCT GCAACCACAT CAAGTATGCC ACCAACCGGG GCAACCTrCG CTCGGCCATC ACAGTGT-7CC CGCAGCGCTG CCCTGGCCGA GGAGACrrCC GAATCTGGAA CAGCCAGCTG GTGCGCTACG CGGGCTACCG GCAGCAGGAC GGCTCTGTGC GGGGGGACCC AGCCAACGTG GAGATCACCG AGCTCTGCAT TCAGCACGGC TGGACCCCAG GAAACGGTCG CrrCGACGTG CTGCCCCTGC TGCTGCAGGC CCCAGATGAG CCCCCAGAAC TCCCT GCCCCCCGAG CTGGTCCTG AGGTGCCCCT GGAGCACCCC ACGCTGGAGT GG=IGCAGC CCTGGGCCTG CGCTGGTACG CCCTCCCGGC AGTGTCCAAC ATG~TGCTGG AAATTGGGGG CCTGGAGTrC CCCGCAGCCC CCTFCAGTGG CTGGTACATG AGCACTGAGA TCGGCACGAG GAACCTGTGT GACCCTCACC GCTACAACAT CCTGGAGGAT GTGGCTrGTCT GCATGGACCT GGATACCCGG ACCACCTCGT CCCTGTGGAA AGACAAGGCA GCAGTGGAAA TCAACGTGGC CGTGCTGCAC AGT'rACCAGC TAGCCAAAGT CACCATCGTG GACCACCACG CCGCCACGGC CTCITCATG AAGCACCTGG AGAATGAGCA GAAGGCCAGG GGGGGCTGCC CTGCAGACTG GGCCTGGATC GTGCCCCCCA TCTCGGGCAG CCTCACTClCT GTITCCATC AGGAGATGGT CAACTA=PC CTGTCCCCGG CCTTCCGCTA CCAGCCAGAC CCCTGGAAGG GGAGTGCCGC CAAGGGCACC WO 00/09525 PCT/US99/17712 EPI-109 216 GGCATCACCA GGAAGAAGAC CTTTAAAGAA GTGGCCAACG CCGTGAAGAT CTCCGCCTCG CTCATGGGCA CGGTGATGGC GAAGCGAGTG AAGGCGACAA TCCTGTATGG CTCCGAGACC GGCCGGGCCC AGAGCTACGC ACAGCAGCTG GGGAGACTCT TCCGGAAGGC TTITGATCCC CGGGTCCTGT GTATGGATGA GTATGACGTG GTGTCCCTCG AACACGAGAC GCTGGTGCTG GTGGTAACCA GCACATTrGG GAATGGGGAT CCCCCGGAGA ATGGAGAGAG CTTGCAGCT GCCCTGATGG AGATGTCCGG CCCCTACAAC AGCTCCCCTC GGCCGGAACA GCACAAGAGT TATAAGATCC GCTTCAACAG CATCTCCTGC TCAGACCCAC TGGTGTCCTC TTGGCGGCGG AAGAGGAAGG AGTCCAGTAA CACAGACAGT GCAGGGGCCC TGGGCACCCT CAGGTITCTGT GTGTTCGGGC TCGGCTCCCG GGCATACCCC CACTTCTGCG CCTTGCTCG TGCCGTGGAC ACACGGCTGG AGGAACTGGG CGGGGAGCGG CTGCTGCAGC TGGGCCAGGG CGACGAGCTG TGCGGCCAGG AGGAGGCC1T CCGAGGCTGG GCCCAGGCTG CCTTCCAGGC CGCCTGTGAG ACCTTCTGTG TGGGAGAGGA TGCCAAGGCC GCCGCCCGAG ACATCTTCAG CCCCAAACGG AGCTGGAAGC GCCAGAGGTA CCGGCTGAGC GCCCAGGCCG AGGGCCTGCA GTTGCTGCCA GGTCTGATCC ACGTGCACAG GCGGAAGATG TTCCAGGCTA CAATCCGCTC AGTGGAAAAC CTGCAAAGCA GCAAGTCCAC GAGGGCCACC ATCCTGGTGC GCCTGGACAC CGGAGGCCAG GAGGGGCTGC AGTACCAGCC GGGGGACCAC ATAGGTGTCT GCCCGCCCAA CCGGCCCGGC CTTGTGGAGG CGCTGCTGAG CCGCGTGGAG GACCCGCCGG CGCCCACTGA GCCCGTGGCA GTAGAGCAGC TGGAGAAGGG CAGCCCTGGT GGCCCTCCCC CCGGCTGGGT GCGGGACCCC CGGCTGCCCC CGTGCACGCT GCGCCAGGCT CTCACCTTCT TCCTGGACAT CACCTCCCCA CCCAGCCCTC AGCTCTTGCG GCTGCTCAGC ACCTTGGCAG AAGAGCCCAG GGAACAGCAG GAGCTGGAGG CCCTCAGCCA GGATCCCCGA CGCTACGAGG AGTGGAAGTG GTTCCGCTGC CCCACGCTGC TGGAGGTGCT GGAGCAGTTC CCGTCGGTGG CGCTGCCTGC CCCACTGCTC CTCACCCAGC TGCCTCTGCT CCAGCCCCGG TACTACTCAG TCAGCTCGGC ACCCAGCACC CACCCAGGAG AGATCCACCT CACTGTAGCT GTGCTGGCAT ACAGGACTCA GGATGGGCTG GGCCCCCTGC ACTATGGAGT CTGCTCCACG TGGCTAAGCC AGCTCAAGCC CGGAGACCCT GTGCCCTGCT TCATCCGGGG GGCTCCCTCC TTCCGGCTGC CACCCGATCC CAGCTTGCCC TGCATCCTGG TGGGTCCAGG CACTGGCATT GCCCCCTTCC GGGGATrCTG GCAGGAGCGG CTGCATGACA TrGAGAGCAA AGGGCTGCAG CCCACTCCCA TGACTGGT GTTCGGCTGC CGATGCTCCC AACTrGACCA TCTCTACCGC GACGAGGTGC AGAACGCCCA GCAGCGCGGG GTGTTTGGCC GAGTCCTCAC CGCCTTCTCC CGGGAACCTG ACAACCCCAA GACCTACGTG CAGGACATCC TGAGGACGGA GCTGGCTGCG GAGGTGCACC GCGTGCTGTG CCTCGAGCGG GGCCACATGT TTGTCTGCGG CGATGTTACC ATGGCAACCA ACGTCCTGCA GACCGTGCAG CGCATCCTGG CGACGGAGGG CGACATGGAG CTGGACGAGG CCGGCGACGT CATCGGCGTG CTGCGGGATC AGCAACGCTA CCACGAAGAC ATITTCGGGC TCACGCTGCG CACCCAGGAG GTGACAAGCC GCATACGCAC CCAGAGCTTI TCCTGCAGG AGCGTCAGTr GCGGGGCGCA GTGCCCTGGG CGTrCGACCC TCCCGGCTCA GACACCAACA GCCCCTGAGA GCCGCCTGGC TTTCCCTTCC AGTTCCGGGA GAGCGGCTGC CCGACTCAGG TCCGCCCGAC CAGGATCAGC CCCGCTCCTC CCCTCTTGAG GTGGTGCCTT CTCACATCTG TCCAGAGGCT GCAAGGATTC AGCATrATTC CTCCAGGAAG GAGCAAAACG CCTCiIrCC CTCTCTAGGC CTGTTGCCTC GGGCCTGGGT CCGCCTTAAT CTGGAAGGCC CCTCCCAGCA GCGGTACCCC AGGGCCrACT GCCACCCGCT TCCTGTTTCT TAGTCCGAAT GTrAGATTCC TCTTGCCTCT CTCAGGAGTA TCTTACCTGT AAAGTCTAAT CTCTAAATCA AGTATATT ATTGAAGATT TACCATAAGG GACTGTGCCA GATGTTAGGA GAACTACTAA AGTGCCTACC CCAGCTC-3' (FRAG. NO: ) (SEQ. ID NO:2508) 5'-CCCCGGGG-3' (FRAG. NO:1898) (SEQ. ID NO: 1909) 5'-GGGGCCGCTGGG-3' (FRAG. NO:1899) (SEQ. ID NO:1910) 5'-GGGGGTGTGG-3' (FRAG. NO:1900) (SEQ. ID NO: 1911) 5'-CTGCCTCCCCGGGGT-3' (FRAG. NO:1442)(SEQ. ID NO:1452) 5'-TrCTGCTGCTTGCTG-3' (FRAG. NO:1443)(SEQ. ID NO:1453) 5'-CrCTTTCCCGTCTCC-3' (FRAG. NO:1444)(SEQ. ID NO:1454) 5'-CTrCTTCCCGTCTCC-3' (FRAG. NO:1445)(SEQ. ID NO:1455) 5'-1TITGCCTCTTTG-3' (FRAG. NO:1446)(SEQ. ID NO:1456) 5'-GGTTCCTGTTGTrTCT-3' (FRAG. NO:1447)(SEQ. ID NO:1457) 5'-GGCCTGCTTGGTGGCG-3' (FRAG. NO:1448)(SEQ. ID NO:1458) 5'-GCTrGTGCGTCC-3' (FRAG. NO:1449)(SEQ. ID NO:1459) 5'-TCTCTCTTCTCTTGGGTCTCCGCTTCTCGTCCTGCC-3' (FRAG. NO:1450)(SEQ. ID NO:1460) 5'-TTCCTGTCTCTGTCGC-3' (FRAG. NO:1451)(SEQ. ID NO:1461) 5'-GCCGTrCCTCCTCC-3' (FRAG. NO:1452)(SEQ. ID NO:1462) 5'-GGCGTCCTCCTGCCC-3' (FRAG. NO:1453)(SEQ. ID NO:1463) 5'-TGTGCTG'TrTGCCTCGG-3' (FRAG. NO:1454)(SEQ. ID NO: 1464) 5'-GTGGTGCGGGTCCC-3' (FRAG. NO:1455)(SEQ. ID NO:1465) 5'-GGTGCTCCCCCGGC-3' (FRAG. NO:1456)(SEQ. ID NO:1466) 5'-GGGCCGGCTGGTrGCCTGGGC-3' (FRAG. NO:1457)(SEQ. ID NO: 1467) 5'-CTGTCTGGTGGGGTGTGGGGCC-3' (FRAG. NO:1458)(SEQ. ID NO:1468) 5'-GCTGGGTrGGGGGTGTGGTG-3' (FRAG. NO:1459)(SEQ. ID NO:1469) 5'-GGCTCTTCTGTGGCC-3' (FRAG. NO:1460)(SEQ. ID NO:1470) 5'-TGTGGGGCTGTrGGTG-3' (FRAG. NO: 1461)(SEQ. ID NO:1471) 5'-TCTCTGTGGGCGTGTG-3' (FRAG. NO: 1462)(SEQ. ID NO: 1472) 5'-CrGGGTCTTGGGGCTrC-3' (FRAG. NO: 1463)(SEQ. ID NO: 1473) 5'-CTCCCTTGTGCTGGG-3' (FRAG. NO:1464)(SEQ. ID NO:1474) 5'-TGCGGCCTCCCCGC-3' (FRAG. NO:1465)(SEQ. ID NO: 1475) 5'-CCCCCTTCTGGGCC-3' (FRAG. NO:1466)(SEQ. ID NO:1476) 5'-GGTGGCCTGGCTCCTrGTGG-3' (FRAG. NO:1467)(SEQ. ID NO: 1477) 5'-GCGCTTCTGGCTCTTG-3' (FRAG. NO:1468)(SEQ. ID NO:1478) 5'-CCCTGTCCTCTTCGCCTCGT-3' (FRAG. NO: 1469)(SEQ. ID NO: 1479) 5'-GGCTGCTGGGCTGC-3' (FRAG. NO: 1470)(SEQ. ID NO:1480) 5'-CTGCCCCBG'rI--GBTCCTCBCBTGCCGTGGGGBGGBCBBTGG-3' (FRAG. NO:1901) (SEQ. ID NO: 1912) NF-kB Nucleic Acids and Antisense Oligonucleotide Fragments 5 -CGGCCCTrCT CACTGGAGGC ACCGGGCAGT CCTCCATGGG AGGGTGGGC TTGGCCGGGG CTGCCCGGTG CCTCCTCTTG GCTGGTCCCT CGTrGTCCTr GGGCCCCGC TCCCGCTGCT CGGCCTCCGT GTTCTGGC CTCTTGCTCC GCCTGCTGTC WO 00/09525 PCTIUS99/17712 EPI-109 217 TTGTCCCGTC CCCTCCTCGC TTGCGTTTCC CTCTTCCTTG TCTTCCAGGC CTTCCTCCGC TTCCGCTGCT GGGGCCCGCG CCGGGGGGGC GCTCGGCTCC GCGGCTTCCT CCCCGGCTGG GGGGTCCTGG TCTCCGGGGC CTGCGGCTCG CGGGCTCGGG GCTGCGTGCG CCGCGCGCGG CGTCCGCGGT GGGTGGCGCT GTCCCGCCGT GGTGTGTCTC CGTTCTCGTC CTGCGCCGTC CTGGTCTGCC CGTGGGGTCC TGGGCGTGGT GGGGGGCGTC TGGTGCCTCG TCTGCCCCGT GGGGCTTCGG GCTCGGGGCT GTTCGTCCCC CCrGCCGCTC TGTGGCCTCC GGGGCTCCTC GTTTTCGCTG CTTCGGGTGT CCTTCTCGGC GTGTGGCCCC GGGTCCCGGC CCTGCTGGGC TGGGCGGGGT CGCTGCCCTG GGCTTCTGGC CCGTCTGGTT GTCTGTCGGT GCTTGTCrCG GGT'ITCTGGC CTCTGTGCTG GGCGCTTCTC TGCCTCCTGC TCCGCCCTCC TGGTGGCTCG GCTGGGGGTG CCCGTGCGGG GGTGGGTGTG GGGTGITIC GGGGTCCTCC CCTTCCC-3' (FRAG. NO:1902) (SEQ. ID NO:1913) 5'-GGGCGGGGTCGC-3' (FRAG. NO:1903) (SEQ. ID NO:1914) 5'-GCGCCGTCC-3' (FRAG. NO:1904) (SEQ. ID NO:1915) 5'-GGGCGTGGTGG-3' (FRAG. NO:1905) (SEQ. ID NO:1916) 5'-GTTGGGCT7GGCCGGGG-3' (FRAG. NO: 1471)(SEQ. ID NO: 1481) 5'-CTGCCCGGTGCCTCC-3' (FRAG. NO: 1472)(SEQ. ID NO:1482) 5'-TCTTGGCTGGTCCCTCGT-3' (FRAG. NO: 1473)(SEQ. ID NO: 1483) 5'-TGTCCTTGGGCCCC-3' (FRAG. NO:1474)(SEQ. ID NO:1484) 5'-GCTCCCGCTGCTCGGCCTCCGT-3' (FRAG. NO:1475)(SEQ. ID NO: 1485) 5'-GTTCTT'GGCCTCTGCTCC-3' (FRAG. NO:1476)(SEQ. ID NO:1486) 5'-GCCTGCTGTCTTGTCC-3' (FRAG. NO: 1477)(SEQ. ID NO: 1487) 5'-CGTCCCCTCCTCGCTTGCGTTTC-3' (FRAG. NO:1478)(SEQ. ID NO:1488) 5'-CCTCTTCCTTGTCTTCCA-3' (FRAG. NO: 1479)(SEQ. ID NO: 1489) 5'-GGCCTTCCTCCGCTTCCGCTGC-3' (FRAG. NO:1480)(SEQ. ID NO: 1490) 5'-TGGGGCCCGCGCCGG-3' (FRAG. NO:1481)(SEQ. ID NO:1491) 5'-GGGGGCGCTCGGCTCCGCGGCTTCCTCCCCGG-3' (FRAG. NO:1482)(SEQ. ID NO:1492) 5-CTGGGGGGTCCTGG-3' (FRAG. NO:1483)(SEQ. ID NO: 1493) 5'-TCTCCGGGGCCTGCGGCTCGC-3' (FRAG. NO:1484)(SEQ. ID NO: 1494) 5-GGGCTCGGGGCTGCGTGCGCC-3' (FRAG. NO:1485)(SEQ. ID NO:1495) 5'-GCGCGCGGCGTCCGCGGTG-3' (FRAG. NO:1486)(SEQ. ID NO: 1496) 5'-GGTGGCGCTGTCCCGCC-3' (FRAG. NO:1487)(SEQ. ID NO:1497) 5'-GTGGTGTGTCrCCG'TTCTCGTCCTGCGCCGTC-3' FRAGG. NO:1488)(SEQ. ID NO:1498) 5'-CTGGTCTGCCCGTGG-3' (FRAG. NO: 1489)(SEQ. ID NO:1499) 5'-GGTCCTGGGCGTGGTGG-3' (FRAG. NO: 1490)(SEQ. ID NO:1500) 5'-GGGGCGTCTGGTGC-3' (FRAG. NO:1491)(SEQ. ID NO:1501) 5'-arCGTCTGCCCCGTG-3' (FRAG. NO: 1492)(SEQ. ID NO: 1502) 5'-GGGCTTCGGGCTCGG-3' (FRAG. NO:1493)(SEQ. ID NO: 1503) 5'-GGCrGTTCGTCCCCCCTGCCGCTCTGTGGCCTCC-3' (FRAG. NO: 1494)(SEQ. ID NO: 1504) 5'-GGGGCTCCTCGT=TC-3' FRAGG. NO: 1495)(SEQ. ID NO: 1505) 5'-GCrGCTrCGGGTGTCCTTCrC-3' (FRAG. NO:1496)(SEQ. ID NO: 1506) 5'-GGCGTGTGGCCCCGG-3' (FRAG. NO:1497)(SEQ. ID NO: 1507) 5'-GTCCCGGCCCTGCTGGGCTGGGCGGGGTC-3' (FRAG. NO:1498)(SEQ. ID NO: 1508) 5'-GCTGCCCTGGGCTTCTGGCCCGTCT-3' (FRAG. NO:1499)(SEQ. ID NO:1509) 5'-GGTTGTCTGTCGGT-3' (FRAG. NO:1500)(SEQ. ID NO: 1510) 5'-GCTTGTCTCGGGTTTCTGG-3' (FRAG. NO:1501)(SEQ. ID NO: 1511) 5'-CCTCTGTGCTGGGC-3' (FRAG. NO:1502)(SEQ. ID NO: 1512) 5'-GCTTCTCTGCCTCCTGCTCC-3' (FRAG. NO: 1503)(SEQ. ID NO: 1513) 5'-GCCCTCCTGGTGGCTC-3' (FRAG. NO:1504)(SEQ. ID NO:1514) 5'-GGCTGGGGGTGCCCGTGCG-3' (FRAG. NO:1505)(SEQ. ID NO:1515) 5'-GGGGTGGGTGTGGGGTGTT-3' (FRAG. NO:1506)(SEQ. ID NO:1516) 5'-TrCGGGGTCCTCCCCTTCCC-3' (FRAG. NO:1507)(SEQ. ID NO:1517) 5'-CGGCCCTTCTCACTGGAGGCACCGGGCAGTCCTCCATGGGAGG-3' (FRAG. NO:1906) (SEQ. ID NO:1917) Human Major Basic Protein Nucleic Acids and Antisense Oligonucleotide Fragments 5'-GTT TCA TCT TGG CTT TAT CCTCT CCC CIT GTT CCT CCC CTCT CCT GCT CTG GRG TCT CCT C TTC CCT CCC TCC CCT GCC GTG TTG TCT GTG GGT GTC GTT TCG CTC TTG TTG CCC TGG GCC CTT CCC TGC TGG GGG GGA G'IT TCA TCr TGG GTT TCB TCT TGG CTT TBT CCTCT CCC CIT GIT car CCC CTCT CCT GCT CTG GRG TCT CCT C TTC CCT CCC TCC CCT GCC GTG TTG TCT GTG GGT GTC GTT TCG CTC TTG TrG CCC TGG GCC CTT CCC TGC TGG GGG GGB GTT TCB TCT TGG-3' (FRAG. ID:1907) (SEQ. ID NO:1918) 5'-GGG GGA GTT-3' (FRAG. ID:1908) (SEQ. ID NO:1919) 5'-G CCC TGG GCC C-3' (FRAG. ID:1909) (SEQ. ID NO:1920) 5'-GTT TCA TCT TGG CTT TAT CC-3' (FRAG. NO:1508) (SEQ. ID NO:1518) 5'-TCT CCC C7T GTT CCT CCC C-3' (FRAG. NO:1509)(SEQ. ID NO:1519) 5'-TCT CCT GCT CTG GRG TCT CCT C-3' (FRAG. NO:1510)(SEQ. ID NO:1520) 5'-TTC CCT CCC TCC CCT GCC-3' (FRAG. NO:1511)(SEQ. ID NO:1521) 5'-GTG TTG TCT GTG GGT GTC C-3' (FRAG. NO: 1512)(SEQ. ID NO: 1522) 5'-G'TT TCG CTC TTG TTG CCC-3' (FRAG. NO:1513)(SEQ. ID NO:1523) 5'-TGG GCC CTT CCC TGC TGG-3' (FRAG. NO:1514)(SEQ. ID NO:1524) 5'-GGG GGA GTr TCA TCT TGG-3' FRAGG. NO:1515)(SEQ. ID NO:1525) 5'-GTr TCA TCT TGG CTT TAT CCTCT CCC CTT GTT CCT CCC CTCT CCT GCT CTG GRG TCT CCT C TTC CCT CCC TCC CCT GCC GTG TTG TCT GTG GGT GTC GTT TCG CTC TTG TTG CCC TGG GCC CTT CCC TGC TGG GGG GGA GTT TCA TCT TGG-3' (FRAG. ID:1910) (SEQ. ID NO:1921) 5'-GTT TCB TCr TGG CTT TBT CCTCT CCC CIT GTT CCT CCC CTCT CCT GCT CTG GRG TCT CCT C TTC CCT CCC TCC WO 00/09525 PCTIUS99/17712 EPI-109 218 CCT GCC GTG ITG TCT GTG GGT GTC GTr TCG CTC TrG TTG CCC TGG GCC CTT CCC TGC TGG GGG GGB GTT TCB TCT TGG-3' (FRAG. ID:1911) (SEQ. ID NO:1922) Human Eosinophil Major Basic Protein Nucleic Acids and Antisense Oligonucleotide Fragments 5'-GGG GGB GT TCB TCT TGG CT T-3 (FRAG. NO:1516)(SEQ. ID NO: 1526) 5'-GGG GGB G7 TCB TCT TGG CTT-3' (FRAG. NO:1517)(SEQ. ID NO:1527) 5'-GGG GGB GT TCB TCT TGG CT-3' (FRAG. NO:1518)(SEQ. ID NO:1528) 5'-GGG GGB GTT TCB TCT TGG C-3' (FRAG. NO:1519)(SEQ. ID NO:1529) 5'-GGG GGB GTT TCB TCT TGG-3' (FRAG. NO:1520)(SEQ. ID NO:1530) 5'-GGG GGB GTT TCB TCT TG-3' (FRAG. NO:1521)(SEQ. ID NO:1531) 5'-GGG GGB GTT TCB TCT T-3' (FRAG. NO:1522)(SEQ. ID NO:1532) 5'-GGG GGB GTT TCB TCT-3' (FRAG. NO: 1523)(SEQ. ID NO:1533) 5'-GGG GGB GT7 TCB TC-3' (FRAG. NO: 1524)(SEQ. ID NO: 1534) 5'-GGG GGB GTT TCB T-3' (FRAG. NO:1525)(SEQ. ID NO: 1535) 5'-GGG GGB GT7 TCB-3' (FRAG. NO: 1526)(SEQ. ID NO: 1536) 5'-GG GGB GT TCB TCT TGG CTT T-3' (FRAG. NO:1527)(SEQ. ID NO: 1537) 5'-GG GGB GTT TCB TCT TGG CTT-3' (FRAG. NO:1528)(SEQ. ID NO: 1538) 5'-GG GGB GTT TCB TCr TGG CT-3' (FRAG. NO:1529)(SEQ. ID NO: 1539) 5'-GG GGB GTT TCB TCT TGG C-3' (FRAG. NO:1530)(SEQ. ID NO: 1540) 5'-GG GGB GTT TCB TCT TGG-3' (FRAG. NO: 1531)(SEQ. ID NO:1541) 5'-GG GGB GTT TCB TCT TG-3' (FRAG. NO:1532)(SEQ. ID NO:1542) 5'-GG GGB GTT TCB TCT T-3' (FRAG. NO:1533)(SEQ. ID NO: 1543) 5'-GG GGB GT7 TCB TCT-3' (FRAG. NO: 1534)(SEQ. ID NO: 1544) 5'-GG GGB GT TCB TC-3' (FRAG. NO:1535)(SEQ. ID NO: 1545) 5'-GG GGB GTT TCB T-3' (FRAG. NO: 1536)(SEQ. ID NO:1546) 5'-G GGB GTT TCB TCT TGG CT T-3' (FRAG. NO:1537)(SEQ. ID NO:1547) 5'-G GGB GTT TCB TCT TGG CTT-3' (FRAG. NO:1538)(SEQ. ID NO:1548) 5'-G GGB GT7 TCB TCT TGG CT-3' (FRAG. NO:1539)(SEQ. ID NO:1549) 5'-G GGB GTT TCB TCT TGG C-3' (FRAG. NO: 1540)(SEQ. ID NO: 1550) 5'-G GGB GTT TCB TCT TGG-3' (FRAG. NO:1541)(SEQ. ID NO:1551) 5'-G GGB GTT TCB TCT TG-3' (FRAG. NO:1542)(SEQ. ID NO:1552) 5'-G GGB GTT TCB TCT T-3' (FRAG. NO:1543)(SEQ. ID NO:1553) 5'-G GGB GTT TCB TCT-3' (FRAG. NO:1544)(SEQ. ID NO: 1554) 5'-G GGB GTT TCB TC-3' (FRAG. NO:1545)(SEQ. ID NO: 1555) 5'-GGB GTT TCB TCT TGG CTT T-3' (FRAG. NO:1546)(SEQ. ID NO:1556) 5'-GGB GTT TCB TCT TGG CTT-3' (FRAG. NO: 1547)(SEQ. ID NO:1557) 5'-GGB GTT TCB TCT TGG CT-3' (FRAG. NO:1548)(SEQ. ID NO:1558) 5'-GGB GiT TCB TCT TGG C-3' (FRAG. NO: 1549)(SEQ. ID NO: 1559) 5'-GGB GTT TCB TCT TGG-3' (FRAG. NO: 1550)(SEQ. ID NO:1560) 5'-GGB GTT TCB TCT TG-3' (FRAG. NO: 1551)(SEQ. ID NO: 1561) 5'-GGB GTT TCB TCT T-3 (FRAG. NO:1552)(SEQ. ID NO:1562) 5 -GGB GTT TCB TCT-3' (FRAG. NO: 1553)(SEQ. ID NO:1563) 5 -GB G7 TCB TCT TGG CIT T-3' (FRAG. NO:1554)(SEQ. ID NO:1564) 5-GB GTT TCB TCT TGG CT-3' (FRAG. NO:1555)(SEQ. ID NO:1565) 5'-GB GTT TCB TCT TGG CT-3' (FRAG. NO:1556)(SEQ. ID NO: 1566) 5'-GB GTT TCB TCT TGG C-3' (FRAG. NO:1557)(SEQ. ID NO: 1567) 5'-GB GTT TCB TCT TGG-3' (FRAG. NO:1558)(SEQ. ID NO:1568) 5'-GB G7 TCB TCT TG-3' (FRAG. NO:1559)(SEQ. ID NO:1569) 5'-GB GTT TCB TCT T-3' (FRAG. NO:1560)(SEQ. ID NO: 1570) 5'-B GTT TCB TCT TGG CIT T-3' (FRAG. NO:1561)(SEQ. ID NO: 1571) 5'-B GTT TCB TCT TGG CT-3' (FRAG. NO: 1562)(SEQ. ID NO:1572) 5'-B GTT TCB TCT TGG CIT-3' (FRAG. NO: 1563)(SEQ. ID NO:1573) 5-B GTT TCB TCT TGG CT-3' (FRAG. NO: 1564)(SEQ. ID NO:1574) 5'-B GTT TCB TCT TGG C-3' (FRAG. NO: 1565)(SEQ. ID NO:1575) 5'-B GTT TCB TCT TGG-3' (FRAG. NO: 1565)(SEQ. ID NO:1576) 5'-B GTT TCB TCT TG-3' (FRAG. NO:1567)(SEQ. ID NO:1577) 5'-GTT TCB TCT TGG CIT T-3' (FRAG. NO:1568)(SEQ. ID NO:1578) 5'-GTT TCB TCT TGG CT-3' (FRAG. NO:1569)(SEQ. ID NO:1579) 5'-GTT TCB TCT TGG CT-3' (FRAG. NO:1570)(SEQ. ID NO:1580) 5'-GTT TCB TCT TGG C-3' (FRAG. NO:1571)(SEQ. ID NO:1581) 5'-GTT TCB TCT TGG-3' (FRAG. NO:1572)(SEQ. ID NO:1582) 5'-TT TCB TCT TGG CTT T-3' (FRAG. NO:1573)(SEQ. ID NO: 1583) 5'-TT TCB TCT TGG CTT-3' (FRAG. NO: 1574)(SEQ. ID NO:1584) 5'-TT TCB TCT TGG CT-3' (FRAG. NO: 1575)(SEQ. ID NO: 1585) 5'-TT TCB TCT TGG C-3 (FRAG. NO:1576)(SEQ. ID NO:1586) 5'-T TCB TCT TGG CIT T-3' (FRAG. NO:1577)(SEQ. ID NO: 1587) 5'-T TCB TCT TGG CTT-3' (FRAG. NO:1578)(SEQ. ID NO:1588) 5-T TCB TCT TGG CT-3' (FRAG. NO:1579)(SEQ. ID NO:1589) 5'-TCB TCT TGG CTT T-3' (FRAG. NO:1580)(SEQ. ID NO: 1590) 5'-TCB TCT TGG CT-3' (FRAG. NO:1581)(SEQ. ID NO:1591) WO 00/09525 PCT/US99/17712 EPI-109 219 5'-GGG GGB GTT TCB TCT TGG CTT T-3' (FRAG. NO: 1582)(SEQ. ID NO:1592) 5'-GG GGB GTT TCB TCT TGG CTT T-3' (FRAG. NO:1583)(SEQ. ID NO: 1593) 5'-G GGB GT TCB TCT TGG CTT T-3' (FRAG. NO: 1584)(SEQ. ID NO:1594) 5'-GGB GTT TCB TCT TGG CTT T-3' (FRAG. NO: 1585)(SEQ. ID NO: 1595) 5'-GB GTT TCB TCT TGG CT T-3' (FRAG. NO:1586)(SEQ. ID NO:1596) 5'-B GTT TCB TCT TGG CTT T-3' (FRAG. NO: 1587)(SEQ. ID NO:1597) 5'-GTT TCB TCT TGG CTT T-3' FRAGG. NO: 1588)(SEQ. ID NO: 1598) 5'-TT TCB TCT TGG CTT T-3' (FRAG. NO:1589)(SEQ. ID NO: 1599) 5'-T TCB TCT TGG CTT T-3' (FRAG. NO:1590)(SEQ. ID NO: 1600) 5'-TCB TCT TGG CTT T-3' (FRAG. NO:1591)(SEQ. ID NO: 1601) 5'-CB TCT TGG CT T-3' (FRAG. NO:1592)(SEQ. ID NO: 1602) 5'-GGG GGB GTT TCB TCT TGG CTT-3' (FRAG. NO:1593)(SEQ. ID NO:1603) 5'-GG GGB GTT TCB TCT TGG CTTr-3' (FRAG. NO:1594)(SEQ. ID NO:1604) 5'-G GGB GT7 TCB TCT TGG CTT-3' (FRAG. NO: 1595)(SEQ. ID NO: 1605) 5'-GGB GTT TCB TCT TGG CTT-3' (FRAG. NO: 1596)(SEQ. ID NO:1606) 5'-GB GTT TCB TCT TGG CTT-3' (FRAG. NO:1597)(SEQ. ID NO:1607) 5'-B GT7 TCB TCT TGG CTT-3' (FRAG. NO: 1598)(SEQ. ID NO:1608) 5'-GTT TCB TCT TGG CTT-3' (FRAG. NO:1599)(SEQ. ID NO:1609) 5'-TT TCB TCT TGG CT7-3' (FRAG. NO: 1600)(SEQ. ID NO: 1610) 5'-T TCB TCT TGG CTT-3' (FRAG. NO:1601)(SEQ. ID NO:1611) 5'-TCB TC TGG CT7-3' (FRAG. NO:1602)(SEQ. ID NO:1612) 5'-GGG GGB GTT TCB TCT TGG CT-3' (FRAG. NO:1603)(SEQ. ID NO: 1613) 5'-GG GGB GTT TCB TCT TGG CT-3' (FRAG. NO: 1604)(SEQ. ID NO:1614) 5'-G GGB GT7 TCB TCT TGG CT-3' (FRAG. NO:1605)(SEQ. ID NO: 1615) 5'-GGB GTT TCB TCT TGG CT-3' (FRAG. NO:1606)(SEQ. ID NO:1616) 5'-GB GTT TCB TCT TGG CT-3' (FRAG. NO:1607)(SEQ. ID NO:1617) 5'-B GTT TCB TCT TGG CT-3' (FRAG. NO: 1608)(SEQ. ID NO:1618) 5'-GTT TCB TCT TGG CT-3' (FRAG. NO: 1609)(SEQ. ID NO:1619) 5'-TT TCB TCT TGG CT-3' (FRAG. NO:1610)(SEQ. ID NO:1620) 5'-T TCB TCT TGG CT-3' (FRAG. NO: 161 1)(SEQ. ID NO:1621) 5'-GGG GGB GT7 TCB TCT TGG C-3' (FRAG. NO: 1612)(SEQ. ID NO: 1622) 5'-GG GGB GTT TCB TCT TGG C-3' (FRAG. NO:1613)(SEQ. ID NO: 1623) 5'-G GGB GTT TCB TCT TGG C-3' (FRAG. NO:1614)(SEQ. ID NO:1624) 5'-GGB GTT TCB TCT TGG C-3' (FRAG. NO:1615)(SEQ. ID NO: 1625) 5'-GB GTT TCB TCT TGG C-3' (FRAG. NO: 1616)(SEQ. ID NO: 1626) 5'-B GTT TCB TCT TGG C-3' (FRAG. NO:1617)(SEQ. ID NO:1627) 5'-GT1 TCB TCT TGG C-3' (FRAG. NO:1618)(SEQ. ID NO: 1628) 5'-TT TCB TCT TGG C-3' (FRAG. NO:1619)(SEQ. ID NO:1629) 5'-GGG GGB GTT TCB TCT TGG-3' (FRAG. NO: 1620)(SEQ. ID NO: 1630) 5'-GO GGB GT1 TCB TCT TGG-3' (FRAG. NO:1621)(SEQ. ID NO:1631) 5'-G GGB GTT TCB TCT TGG-3' (FRAG. NO:1622)(SEQ. ID NO:1632) 5'-GGB GTT TCB TCT TGG-3' (FRAG. NO:1623)(SEQ. ID NO: 1633) 5'-GB GTT TCB TCT TGG-3' (FRAG. NO:1624)(SEQ. ID NO: 1634) 5'-B GTT TCB TCT TGG-3' (FRAG. NO:1625)(SEQ. ID NO:1635) 5'-GT TCB TCT TGG-3' (FRAG. NO:1626)(SEQ. ID NO:1636) 5'-GGG GGB GT7 TCB TCT TG-3' (FRAG. NO:1627)(SEQ. ID NO:1637) 5'-GG GGB GTT TCB TCT TG-3' (FRAG. NO:1628)(SEQ. ID NO:1638) 5'-G GGB GTT TCB TCT TG-3' (FRAG. NO:1629)(SEQ. ID NO:1639) 5'-GGB GTT TCB TCT TG-3' FRAGG. NO:1630)(SEQ. ID NO:1640) 5'-GB GTT TCB TC TG-3' (FRAG. NO:1631)(SEQ. ID NO:1641) 5'-B GT TCB TCT TG-3' (FRAG. NO: 1632)(SEQ. ID NO:1642) 5'-GGG GGB GT TCB TCT T-3' (FRAG. NO:1633)(SEQ. ID NO:1643) 5'-GG GGB GTT TCB TCT T-3' (FRAG. NO:1634)(SEQ. ID NO: 1644) 5'-G GGB GTT TCB TCT T-3' (FRAG. NO:1635)(SEQ. ID NO:1645) 5'-G GGB GTT TCB TCT T-3' (FRAG. NO: 1636)(SEQ. ID NO: 1646) 5'-GGB GTT TCB TCT T-3' (FRAG. NO:1637)(SEQ. ID NO:1647) 5'-GB GTT TCB TCT T-3' (FRAG. NO:1638)(SEQ. ID NO: 1648) 5'-GGG GGB GTT TCB TCT-3' (FRAG. NO:1639)(SEQ. ID NO: 1649) 5'-GG GGB GTT TCB TCT-3' (FRAG. NO:1640)(SEQ. ID NO:1650) 5'-G GGB GTT TCB TCT-3' (FRAG. NO: 1641)(SEQ. ID NO:1651) 5'-GGB GTT TCB TCT-3' (FRAG. NO:1642)(SEQ. ID NO:1652) 5'-GGG GGB GTT TCB TC-3' FRAGG. NO:1643)(SEQ. ID NO: 1653) 5'-GG GGB GTT TCB TC-3' (FRAG. NO: 1644)(SEQ. ID NO: 1654) 5'-G GGB GTT TCB TC-3' (FRAG. NO: 1645)(SEQ. ID NO:1655) 5'-GGG GGB GTT TCB T-3' (FRAG. NO:1646)(SEQ. ID NO: 1656) 5'-GG GGB GTT TCB T-3' (FRAG. NO: 1647)(SEQ. ID NO: 1657) 5-GGG GGB GTT TCB-3' (FRAG. NO: 1648)(SEQ. ID NO: 1658) 5'-TCT CCC CTT GTT CCT CCC C-3' (FRAG. NO:1649)(SEQ. ID NO:1659) 5'-TCT CCT GCT CTG GTG TCT CCT C-3' (FRAG. NO:1650)(SEQ. ID NO: 1660) WO 00/09525 PCT/US99/17712 EPI-109 220 5'-TTC CCT CCC TCC CCT GCC-3' (FRAG. NO:1651)(SEQ. ID NO:1661) 5'-GTG T'G TCT GTG GGT GTC C-3' (FRAG. NO:1652)(SEQ. ID NO:1662) 5'-GTT TCG CTC T'G TTG CCC-3' -3' (FRAG. NO:1653)(SEQ. ID NO: 1663) 5'-TGG GCC CTT CCC TGC TGG-3' (FRAG. NO:1654)(SEQ. ID NO:1664) 5'-GGG GGB G-3' (FRAG. NO:1912)(SEQ. ID NO:1923) 5'-GTG GGT GTC C-3' (FRAG. NO:1913) (SEQ. ID NO:1924) BP-1 Nucleic Acids and Antisense Oligonucleotide Fragments 5'-CCGTGTTGTC BGTGGTGCTG CCCGTTTGBG GTBTGGCGCT CCBCCBBTTC CCTTTTCTCC TTGTTTTCCG TTTCTCTTGC CGTCTGTGGT T-3' (FRAG. NO:1914) (SEQ. ID NO:1925) 5'-CCCGTTTGBGGTBTGGC-3'(FRAG. NO:1915) (SEQ. ID NO:1926) 5'-GCTCCBCCBBTTCCCTTTTCTCC-3'(FRAG. NO:1916) (SEQ. ID NO:1927) 5'-TrGTTTTCCGTTTCTCTTG-3'(FRAG. NO:1917) (SEQ. ID NO:1928) 5'-CCGTCTGTGGTT-3'(FRAG. NO:1918) (SEQ. ID NO:1929) 5'-CCCGTTTGAGGTATGGC-3'(FRAG. NO:1919) (SEQ. ID NO:1930) 5'-GCTCCBCCAATTCCCTTTTCTCC-3'(FRAG. NO:1920) (SEQ. ID NO:1931) C/EBPNucleic Acids and Antisense Oligonucleotide Antisense Oligonucleotide Fragments 5'-GGGCCCBGCCCCGCCGCCTTTTCTBGCCCC GGCC-3' (FRAG. NO:1921) (SEQ. ID NO:1932) 5'-GGGCCCBGCCCCGCCGCC'IT ICTBGCCCC GGC-3' (FRAG. NO:1922) (SEQ. ID NO:1933) 5'-GGGCCCB GCCCCGCCGCCT iTCTBGCCCCGG-3' (FRAG. NO:1923) (SEQ. ID NO:1934) 5'-GGGCCCBGCCCCGCCGCCTITTCTBGCCCCG-3' (FRAG. NO:1924) (SEQ. ID NO:1935) 5'-GGGCCCBGCCCCGCCGCC TIiCTBGCCCC-3' (FRAG. NO:1925) (SEQ. ID NO:1936) 5'-GGGCCCBGCCCCGCCGCCTTTTCTBGCCC-3' (FRAG. NO:1926) (SEQ. ID NO:1937) 5'-GGGCCCBGCCCCGCCGCCTTTTCTBGCC-3' (FRAG. NO:1927) (SEQ. ID NO:1938) 5'-GGGCCCBGCCCCGCCGCCTTTCTBGC-3' (FRAG. NO:1928) (SEQ. ID NO:1939) 5'-GGGCCCBGCCCCGCCGCCTTTTCTBG-3' (FRAG. NO:1929) (SEQ. ID NO:1940) 5'-GGGCCCBGCCCCGCCGCCTTTTCTB-3' (FRAG. NO:1930) (SEQ. ID NO:1941) 5'-GGGCCCBGCCCCGCCGCCTTTTCT-3' (FRAG. NO:1931) (SEQ. ID NO:1942) 5'-GGGCCCBGCCCCGCCGCCTT=TC-3' (FRAG. NO:1932) (SEQ. ID NO:1943) 5'-GGGCCCBGCCCCGCCGCCTTTT-3' (FRAG. NO:1933) (SEQ. ID NO:1944) 5'-GGGCCCBGCCCCGCCGCCTTT-3' (FRAG. NO:1934) (SEQ. ID NO:1945) 5'-GGGCCCBGCCCCGCCGCCTT-3' (FRAG. NO:1935) (SEQ. ID NO:1946) 5'-GGGCCCBGCCCCGCCGCCT-3' (FRAG. NO:1936) (SEQ. ID NO:1947) 5'-GGGCCCBGCCCCGCCGCC-3' (FRAG. NO:1937) (SEQ. ID NO:1948) 5'-GGGCCCBGCCCCGCCGC-3' (FRAG. NO:1938) (SEQ. ID NO:1949) 5'-GGGCCCBGCCCCGCCG-3' (FRAG. NO:1939) (SEQ. ID NO:1950) 5'-GGGCCCBGCCCCGCC-3' (FRAG. NO:1940) (SEQ. ID NO:1951) 5'-GGGCCCBGCCCCGC-3' (FRAG. NO:1941) (SEQ. ID NO:1952) 5'-GGGCCCBGCCCCG-3' (FRAG. NO:1942) (SEQ. ID NO:1953) 5'-GGGCCCBGCCCC-3' (FRAG. NO:1943) (SEQ. ID NO:1954) 5'-GGGCCCBGCCC-3' (FRAG. NO:1944) (SEQ. ID NO:1955) 5-GGCCCBGCCCCGCCGCCTTTTCTBGCCCCGGC-3' (FRAG. NO:1945) (SEQ. ID NO:1956) 5'-GCCCBGCCCCGCCGCCTTTTCTBGCCCCGGC-3' (FRAG. NO:1946) (SEQ. ID NO:1957) 5'-CCCBGCCCCGCCGCCTTTTCTBGCCCCGGC-3'(FRAG. NO:1947) (SEQ. ID NO:1958) 5'-CCBGCCCCGCCGCCTTTTCTBGCCCCGGC-3' (FRAG. NO:1948) (SEQ. ID NO:1959) 5'-CBGCCCCGCCGCCTTTTCTBGCCCCGGC-3' (FRAG. NO:1948) (SEQ. ID NO:1960) 5'-BGCCCCGCCGCCTTTTCTBGCCCCGGC-3' (FRAG. NO:1950) (SEQ. ID NO:1961) 5'-GCCCCGCCGCCTTTTCTBGCCCCGGC-3' (FRAG. NO:1951) (SEQ. ID NO:1962) 5'-CCCCGCCGCCTTTTCTBGCCCCGGC-3' (FRAG. NO:1952) (SEQ. ID NO:1963) 5'-CCCGCCGCCTTTTCTBGCCCCGGC-3' (FRAG. NO:1953) (SEQ. ID NO:1964) 5'-CCGCCGCCTTTTCTBGCCCCGGC-3' (FRAG. NO:1954) (SEQ. ID NO:1965) 5'-CGCCGCCTTTTCTBGCCCCGGC-3'(FRAG. NO:1955) (SEQ. ID NO:1966) 5'-GCCGCCTTTTCTBGCCCCGGC-3' (FRAG. NO:1956) (SEQ. ID NO:1967) 5'-CCGCCTTTTCTBGCCCCGGC-3' (FRAG. NO:1957) (SEQ. ID NO:1968) 5'-CGCCTTTTCTBGCCCCGGC-3' (FRAG. NO:1958) (SEQ. ID NO:1969) 5'-GCCTTTTCTBGCCCCGGC-3' (FRAG. NO:1959) (SEQ. ID NO:1970) 5'-CCTTTTCTBGCCCCGGC-3'(FRAG. NO:1960) (SEQ. ID NO:1971) 5'-CTTTTCTBGCCCCGGC-3' (FRAG. NO:1961) (SEQ. ID NO:1972) 5'-TTTTCTBGCCCCGGC-3'(FRAG. NO:1962) (SEQ. ID NO:1973) 5'-TTTCTBGCCCCGGC-3' (FRAG. NO:1963) (SEQ. ID NO:1974) 5'-TTCTBGCCCCGGC-3'(FRAG. NO:1964) (SEQ. ID NO:1975) 5'-TCTBGCCCCGGC-3' (FRAG. NO:1965) (SEQ. ID NO:1976) 5'-CTBGCCCCGGC-3' (FRAG. NO:1966) (SEQ. ID NO:1977) 5'-GCGBGGCTGTCBCCTCGCTGGGCCC-3' (FRAG. NO:1967) (SEQ. ID NO:1978) 5'-GCGBGGCTGTCBCCTCGCTGGGCC-3'(FRAG. NO:1968) (SEQ. ID NO:1979) 5'-GCGBGGCTGTCBCCTCGCTGGGC-3' (FRAG. NO:1969) (SEQ. ID NO:1980) WO 00/09525 PCT/US99/17712 EPI-109 221 5'-GCGBGGCTGTCBCCTCGCTGGG-3' (FRAG. NO:1970) (SEQ. ID NO:1981) 5'-GCGBGGCTGTCBCCTCGCTGG-3' FRAGG. NO:1971) (SEQ. ID NO:1982) 5'-GCGBGGCTGTCBCCTCGCTG-3 FRAGG. NO:1972) (SEQ. ID NO:1983) 5'-GCGBGGCTGTCBCCTCGCT-3' FRAGG. NO:1973) (SEQ. ID NO:1984) 5'-GCGBGGCTGTCBCCTCGC-3' FRAGG. NO:1974) (SEQ. ID NO:1985) 5'-GCGBGGCTGTCBCCTCG-3' (FRAG. NO:1975) (SEQ. ID NO:1986) 5-GCGBGGCTGTCBCCTC-3' FRAGG. NO:1976) (SEQ. ID NO:1987) 5'-GCGBGGCTGTCBCCT-3' FRAGG. NO:1977) (SEQ. ID NO:1988) 5'-GCGBGGCTGTCBCC-3'(FRAG. NO:1978) (SEQ. ID NO:1989) 5'-GCGBGGCTGTCBC-3' FRAGG. NO:1979) (SEQ. ID NO:1990) 5'-GCGBGGCTGTCB-3' FRAGG. NO:1980) (SEQ. ID NO:1991) 5'-GCGBGGCTGTC-3' FRAGG. NO:1981) (SEQ. ID NO:1992) 5'-GCGBGGCTGT-3' FRAGG. NO:1982) (SEQ. ID NO:1993) 5'-CGBGGCTGTCBCCTCGCTGGGCCC-3' FRAGG. NO:1983) (SEQ. ID NO:1994) 5'-GBGGCTGTCBCCTCGCTGGGCCC-3' FRAGG. NO:1984) (SEQ. ID NO:1995) 5'-BGGCTGTCBCCTCGCTGGGCCC-3' FRAGG. NO:1985) (SEQ. ID NO:1996) 5'-GGCTGTCBCCTCGCTGGGCCC-3' FRAGG. NO:1986) (SEQ. ID NO:1997) 5'-GCTGTCBCCTCGCTGGGCCC-3' FRAGG. NO:1987) (SEQ. ID NO:1998) 5'-CTGTCBCCTCGCTGGGCCC-3' FRAGG. NO:1988) (SEQ. ID NO:1999) 5'-TGTCBCCTCGCTGGGCCC-3' FRAGG. NO:1989) (SEQ. ID NO:2000) 5'-GTCBCCTCGCTGGGCCC-3' FRAGG. NO:1990) (SEQ. ID NO:2001) 5'-TCBCCTCGCTGGGCCC-3'(FRAG. NO:1991) (SEQ. ID NO:2002) 5'-CBCCTCGCTGGGCCC-3' (FRAG. NO:1992) (SEQ. ID NO:2003) 5'-BCCTCGCTGGGCCC-3' (FRAG. NO:1993) (SEQ. ID NO:2004) 5'-CCTCGCTGGGCCC-3' FRAGG. NO:1994) (SEQ. ID NO:2005) 5'-CTCGCTGGGCCC-3' FRAGG. NO:1995) (SEQ. ID NO:2006) 5'-TCGCTGGGCCC-3' FRAGG. NO:1996) (SEQ. ID NO:2007) 5'-CGCTGGGCCC-3' FRAGG. NO:1997) (SEQ. ID NO:2008) 5'-GCGCGGCCGTCBTGGCGGCGTCGGGCCGGGC-3' FRAGG. NO:1998) (SEQ. ID NO:2009) 5'-GCGCGGCCGTCBTGGCGGCGTCGGGCCGGG-3' FRAGG. NO:1999) (SEQ. ID NO:2010) 5'-GCGCGGCCGTCBTGGCGGCGTCGGGCCGG-3' (FRAG. NO:2000) (SEQ. ID NO:2011) 5'-GCGCGGCCGTCBTGGCGGCGTCGGGCCG-3'(FRAG. NO:2001) (SEQ. ID NO:2012) 5'-GCGCGGCCGTCBTGGCGGCGTCGGGCC-3'(FRAG. NO:2002) (SEQ. ID NO:2013) 5'-GCGCGGCCGTCBTGGCGGCGTCGGGC-3' (FRAG. NO:2003) (SEQ. ID NO:2014) 5'-GCGCGGCCGTCBTGGCGGCGTCGGG-3' FRAGG. NO:2004) (SEQ. ID NO:2015) 5'-GCGCGGCCGTCBTGGCGGCGTCGG-3' FRAGG. NO:2005) (SEQ. ID NO:2016) 5'-GCGCGGCCGTCBTGGCGGCGTCG-3' (FRAG. NO:2006) (SEQ. ID NO:2017) 5'-GCGCGGCCGTCBTGGCGGCGTC-3' FRAGG. NO:2007) (SEQ. ID NO:2018) 5-GCGCGGCCGTCBTGGCGGCGT-3' FRAGG. NO:2008) (SEQ. ID NO:2019) 5'-GCGCGGCCGTCBTGGCGGCG-3' FRAGG. NO:2009) (SEQ. ID NO:2020) 5-GCGCGGCCGTCBTGGCGGC-3' FRAGG. NO:2010) (SEQ. ID NO:2021) 5'-GCGCGGCCGTCBTGGCGG-3' FRAGG. NO:2011) (SEQ. ID NO:2022) 5'-GCGCGGCCGTCBTGGCG-3' FRAGG. NO:2012) (SEQ. ID NO:2023) 5 -GCGCGGCCGTCBTGGC-3' (FRAG. NO:2013) (SEQ. ID NO:2024) 5'-GCGCGGCCGTCBTGG-3' FRAGG. NO:2014) (SEQ. ID NO:2025) 5'-GCGCGGCCGTCBTG-3' (FRAG. NO:2015) (SEQ. ID NO:2026) 5'-GCGCGGCCGTCBT-3' FRAGG. NO:2016) (SEQ. ID NO:2027) 5'-GCGCGGCCGTCB-3' FRAGG. NO:2017) (SEQ. ID NO:2028) 5'-GCGCGGCCGTC-3' FRAGG. NO:2018) (SEQ. ID NO:2029) 5'-GCGCGGCCGT-3'(FRAG. NO:2019) (SEQ. ID NO:2030) 5'-CGCGGCCGTCBTGGCGGCGTCGGGCCGGGC-3' FRAGG. NO:2020) (SEQ. ID NO:2031) 5'-GCGGCCGTCBTGGCGGCGTCGGGCCGGGC-3'(FRAG. NO:2021) (SEQ. ID NO:2032) 5'-CGGCCGTCBTGGCGGCGTCGGGCCGGGC-3'(FRAG. NO:2022) (SEQ. ID NO:2033) 5'-GGCCGTCBTGGCGGCGTCGGGCCGGGC-3'(FRAG. NO:2023) (SEQ. ID NO:2034) 5'-GCCGTCBTGGCGGCGTCGGGCCGGGC-3' FRAGG. NO:2024) (SEQ. ID NO:2035) 5'-CCGTCBTGGCGGCGTCGGGCCGGGC-3'(FRAG. NO:2025) (SEQ. ID NO:2036) 5'-CGTCBTGGCGGCGTCGGGCCGGGC-3' FRAGG. NO:2026) (SEQ. ID NO:2037) 5'-GTCBTGGCGGCGTCGGGCCGGGC-3 FRAGG. NO:2027) (SEQ. ID NO:2038) 5'-TCBTGGCGGCGTCGGGCCGGGC-3' FRAGG. NO:2028) (SEQ. ID NO:2039) 5'-CBTGGCGGCGTCGGGCCGGGC-3'(FRAG. NO:2029) (SEQ. ID NO:2040) 5'-BTGGCGGCGTCGGGCCGGGC-3' FRAGG. NO:2030) (SEQ. ID NO:2041) 5'-TGGCGGCGTCGGGCCGGGC-3' FRAGG. NO:2031) (SEQ. ID NO:2042) 5-GGCGGCGTCGGGCCGGGC-3' FRAGG. NO:2032) (SEQ. ID NO:2043) 5'-GCGGCGTCGGGCCGGGC-3' FRAGG. NO:2033) (SEQ. ID NO:2044) 5-CGGCGTCGGGCCGGGC-3' FRAGG. NO:2034) (SEQ. ID NO:2045) WO 00/09525 PCT/US99/17712 EPI-109 222 5'-GGCGTCGGGCCGGGC-3'(FRAG. NO:2035) (SEQ. ID NO:2046) 5'-GCGTCGGGCCGGGC-3' (FRAG. NO:2036) (SEQ. ID NO:2047) 5'-CGTCGGGCCGGGC-3'(FRAG. NO:2037) (SEQ. ID NO:2048) 5'-GTCGGGCCGGGC-3'(FRAG. NO:2038) (SEQ. ID NO:2049) 5'-TCGGGCCGGGC-3' (FRAG. NO:2039) (SEQ. ID NO:2050) 5'-CGGGCCGGGC-3' (FRAG. NO:2040) (SEQ. ID NO:2051) 5'-CCGCBGGCCBGGGCGCGCCGCCGGCCGGGCCG-3' (FRAG. NO:2041) (SEQ. ID NO:2052) 5'-CCGCBGGCCBGGGCGCGCCGCCGGCCGGGCC-3' (FRAG. NO:2042) (SEQ. ID NO:2053) 5'-CCGCBGGCCBGGGCGCGCCGCCGGCCGGGC-3' (FRAG. NO:2043) (SEQ. ID NO:2054) 5'-CCGCBGGCCBGGGCGCGCCGCCGGCCGGG-3' (FRAG. NO:2044) (SEQ. ID NO:2055) 5'-CCGCBGGCCBGGGCGCGCCGCCGGCCGG-3'(FRAG. NO:2045) (SEQ. ID NO:2056) 5'-CCGCBGGCCBGGGCGCGCCGCCGGCCG-3' (FRAG. NO:2046) (SEQ. ID NO:2057) 5-CCGCBGGCCBGGGCGCGCCGCCGGCC-3' (FRAG. NO:2047) (SEQ. ID NO:2058) 5'-CCGCBGGCCBGGGCGCGCCGCCGGC-3' (FRAG. NO:2048) (SEQ. ID NO:2059) 5'-CCGCBGGCCBGGGCGCGCCGCCGG-3' (FRAG. NO:2049) (SEQ. ID NO:2060) 5'-CCGCBGGCCBGGGCGCGCCGCCG-3' (FRAG. NO:2050) (SEQ. ID NO:2061) 5'-CCGCBGGCCBGGGCGCGCCGCC-3' (FRAG. NO:2051) (SEQ. ID NO:2062) 5'-CCGCBGGCCBGGGCGCGCCGC-3' (FRAG. NO:2052) (SEQ. ID NO:2063) 5'-CCGCBGGCCBGGGCGCGCCG-3' (FRAG. NO:2053) (SEQ. ID NO:2064) 5'-CCGCBGGCCBGGGCGCGCC-3' (FRAG. NO:2054) (SEQ. ID NO:2065) 5'-CCGCBGGCCBGGGCGCGC-3' (FRAG. NO:2055) (SEQ. ID NO:2066) 5'-CCGCBGGCCBGGGCGCG-3' (FRAG. NO:2056) (SEQ. ID NO:2067) 5'-CCGCBGGCCBGGGCGC-3' (FRAG. NO:2057) (SEQ. ID NO:2068) 5'-CCGCBGGCCBGGGCG-3' (FRAG. NO:2058) (SEQ. ID NO:2069) 5'-CCGCBGGCCBGGGC-3'(FRAG. NO:2059) (SEQ. ID NO:2070) 5'-CCGCBGGCCBGGG-3' (FRAG. NO:2060) (SEQ. ID NO:2071) 5'-CCGCBGGCCBGG-3' (FRAG. NO:2061) (SEQ. ID NO:2072) 5'-CCGCBGGCCBG-3' (FRAG. NO:2062) (SEQ. ID NO:2073) 5'-CCGCBGGCCB-3' (FRAG. NO:2063) (SEQ. ID NO:2074) 5'-CCGCBGGCC-3' (FRAG. NO:2064) (SEQ. ID NO:2075) 5'-CGCBGGCCBGGGCGCGCCGCCGGCCGGGCCG-3' (FRAG. NO:2065) (SEQ. ID NO:2076) 5'-GCBGGCCBGGGCGCGCCGCCGGCCGGGCCG-3' (FRAG. NO:2066) (SEQ. ID NO:2077) 5'-CBGGCCBGGGCGCGCCGCCGGCCGGGCCG-3' (FRAG. NO:2067) (SEQ. ID NO:2078) 5'-BGGCCBGGGCGCGCCGCCGGCCGGGCCG-3' (FRAG. NO:2068) (SEQ. ID NO:2079) 5'-GGCCBGGGCGCGCCGCCGGCCGGGCCG-3' (FRAG. NO:2069) (SEQ. ID NO:2080) 5'-GCCBGGGCGCGCCGCCGGCCGGGCCG-3' (FRAG. NO:2070) (SEQ. ID NO:2081) 5'-CCBGGGCGCGCCGCCGGCCGGGCCG-3' (FRAG. NO:2071) (SEQ. ID NO:2082) 5'-CBGGGCGCGCCGCCGGCCGGGCCG-3' (FRAG. NO:2072) (SEQ. ID NO:2083) 5-BGGGCGCGCCGCCGGCCGGGCCG-3 (FRAG. NO:2073) (SEQ. ID NO:2084) 5 -GGGCGCGCCGCCGGCCGGGCCG-3' (FRAG. NO:2074) (SEQ. ID NO:2085) 5'-GGCGCGCCGCCGGCCGGGCCG-3' (FRAG. NO:2075) (SEQ. ID NO:2086) 5'-GCGCGCCGCCGGCCGGGCCG-3' (FRAG. NO:2076) (SEQ. ID NO:2087) 5'-CGCGCCGCCGGCCGGGCCG-3' (FRAG. NO:2077) (SEQ. ID NO:2088) 5'-GCGCCGCCGGCCGGGCCG-3' (FRAG. NO:2078) (SEQ. ID NO:2089) 5'-CGCCGCCGGCCGGGCCG-3' (FRAG. NO:2079) (SEQ. ID NO:2090) 5'-GCCGCCGGCCGGGCCG-3 (FRAG. NO:2080) (SEQ. ID NO:2091) 5'-CCGCCGGCCGGGCCG-3' FRAGG. NO:2081) (SEQ. ID NO:2092) 5'-CGCCGGCCGGGCCG-3' (FRAG. NO:2082) (SEQ. ID NO:2093) 5'-GCCGGCCGGGCCG-3' (FRAG. NO:2083) (SEQ. ID NO:2094) 5'-CCGGCCGGGCCG-3' (FRAG. NO:2084) (SEQ. ID NO:2095) 5'-CGGCCGGGCCG-3' (FRAG. NO:2085) (SEQ. ID NO:2096) 5'-GGCCGGGCCG-3' (FRAG. NO:2086) (SEQ. ID NO:2097) 5'-GGGCGCBGGCTCCGCB-3' (FRAG. NO:2087) (SEQ. ID NO:2098) 5'-GGGCCCCTGGCTCGGCCCCGCGGCCCGGCTTrGCCCGCCCGGCCCGG-3'(FRAG. NO:2088) (SEQ. ID NO:2099) 5'-GGGCCCCTGGCTCGGCCCCGCGGCCCGGCTTGCCCGCCCGGCCCG-3' (FRAG. NO:2089) (SEQ. ID NO:2100) 5'-GGGCCCCTGGCTCGGCCCCGCGGCCCGGCTrGCCCGCCCGGCCC-3' (FRAG. NO:2090) (SEQ. ID NO:2101) 5'-GGGCCCCTGGCTCGGCCCCGCGGCCCGGCTrGCCCGCCCGGCC-3' (FRAG. NO:2091) (SEQ. ID NO:2102) 5'-GGGCCCCTGGCTCGGCCCCGCGGCCCGGCTTGCCCGCCCGGC-3' (FRAG. NO:2092) (SEQ. ID NO:2103) 5'-GGGCCCCTGGCTCGGCCCCGCGGCCCGGCTTGCCCGCCCGG-3' (FRAG. NO:2093) (SEQ. ID NO:2104) 5'-GGGCCCCTGGCTCGGCCCCGCGGCCCGGCTTGCCCGCCCG-3' (FRAG. NO:2094) (SEQ. ID NO:2105) 5'-GGGCCCCTGGCTCGGCCCCGCGGCCCGGCTTGCCCGCCC-3' (FRAG. NO:2095) (SEQ. ID NO:2106) 5'-GGGCCCCTGGCTCGGCCCCGCGGCCCGGCTTGCCCGCC-3' (FRAG. NO:2096) (SEQ. ID NO:2107) 5'-GGGCCCCTGGCTCGGCCCCGCGGCCCGGCTTGCCCGC-3' (FRAG. NO:2097) (SEQ. ID NO:2108) 5'-GGGCCCCTGGCTCGGCCCCGCGGCCCGGCTTGCCCG-3' (FRAG. NO:2098) (SEQ. ID NO:2109) 5'-GGGCCCCTGGCTCGGCCCCGCGGCCCGGCTrGCCC-3' (FRAG. NO:2099) (SEQ. ID NO:21 10) WO 00/09525 PCT/US99/17712 EPI-109 223 5'-GGGCCCCTGGCTCGGCCCCGCGGCCCGGCTTGCC-3' (FRAG. NO:2100) (SEQ. ID NO:2111) 5'-GGGCCCCTGGCTCGGCCCCGCGGCCCGGCTTGC-3'(FRAG. NO:2101) (SEQ. ID NO:2112) 5'-GGGCCCCTGGCTCGGCCCCGCGGCCCGGCTTG-3'(FRAG. NO:2102) (SEQ. ID NO:2113) 5'-GGGCCCCTGGCTCGGCCCCGCGGCCCGGCTT-3'(FRAG. NO:2103) (SEQ. ID NO:2114) 5'-GGGCCCCTGGCTCGGCCCCGCGGCCCGGCT-3' (FRAG. NO:2104) (SEQ. ID NO:2115) 5'-GGGCCCCTGGCTCGGCCCCGCGGCCCGGC-3' (FRAG. NO:2105) (SEQ. ID NO:2116) 5'-GGGCCCCTGGCTCGGCCCCGCGGCCCGG-3' (FRAG. NO:2106) (SEQ. ID NO:2117) 5'-GGGCCCCTGGCTCGGCCCCGCGGCCCG-3' (FRAG. NO:2107) (SEQ. ID NO:2118) 5'-GGGCCCCTGGCTCGGCCCCGCGGCCC-3' (FRAG. NO:2108) (SEQ. ID NO:2119) 5'-GGGCCCCTGGCTCGGCCCCGCGGCC-3' (FRAG. NO:2109) (SEQ. ID NO:2120) 5'-GGGCCCCTGGCTCGGCCCCGCGGC-3' (FRAG. NO:2110) (SEQ. ID NO:2121) 5'-GGGCCCCTGGCTCGGCCCCGCGG-3' (FRAG. NO:2111) (SEQ. ID NO:2122) 5'-GGGCCCCTGGCTCGGCCCCGCG-3' (FRAG. NO:2112) (SEQ. ID NO:2123) 5'-GGGCCCCTGGCTCGGCCCCGC-3' (FRAG. NO:2113) (SEQ. ID NO:2124) 5'-GGGCCCCTGGCTCGGCCCCG-3' (FRAG. NO:2114) (SEQ. ID NO:2125) 5'-GGGCCCCTGGCTCGGCCCC-3' (FRAG. NO:2115) (SEQ. ID NO:2126) 5'-GGGCCCCTGGCTCGGCCC-3' (FRAG. NO:2116) (SEQ. ID NO:2127) 5'-GGGCCCCTGGCTCGGCC-3' (FRAG. NO:2117) (SEQ. ID NO:2128) 5'-GGGCCCCTGGCTCGGC-3' (FRAG. NO:2118) (SEQ. ID NO:2129) 5'-GGGCCCCTGGCTCGG-3' (FRAG. NO:2119) (SEQ. ID NO:2130) 5'-GGGCCCCTGGCTCG-3' (FRAG. NO:2120) (SEQ. ID NO:2131) 5'-GGGCCCCTGGCTC-3' (FRAG. NO:2121) (SEQ. ID NO:2132) 5'-GGGCCCCTGGCT-3' (FRAG. NO:2122) (SEQ. ID NO:2133) 5'-GGCCCCTGGCTCGGCCCCGCGGCCCGGCTTGCCCGCCCGGCCCGG-3' (FRAG. NO:2123) (SEQ. ID NO:2134) 5'-GCCCCTGGCTCGGCCCCGCGGCCCGGCTTGCCCGCCCGGCCCGG-3' (FRAG. NO:2124) (SEQ. ID NO:2135) 5'-CCCCTGGCTCGGCCCCGCGGCCCGGCTTGCCCGCCCGGCCCGG-3' (FRAG. NO:2125) (SEQ. ID NO:2136) 5'-CCCTGGCTCGGCCCCGCGGCCCGGCTrGCCCGCCCGGCCCGG-3' (FRAG. NO:2126) (SEQ. ID NO:2137) 5'-CCTGGCTCGGCCCCGCGGCCCGGCTTGCCCGCCCGGCCCGG-3' (FRAG. NO:2127) (SEQ. ID NO:2138) 5'-CTGGCTCGGCCCCGCGGCCCGGCTTGCCCGCCCGGCCCGG-3' (FRAG. NO:2128) (SEQ. ID NO:2139) 5'-TGGCTCGGCCCCGCGGCCCGGCTFGCCCGCCCGGCCCGG-3' (FRAG. NO:2129) (SEQ. ID NO:2140) 5'-GGCTCGGCCCCGCGGCCCGGCTTGCCCGCCCGGCCCGG-3' (FRAG. NO:2130) (SEQ. ID NO:2141) 5'-GCTCGGCCCCGCGGCCCGGCTTGCCCGCCCGGCCCGG-3' (FRAG. NO:2131) (SEQ. ID NO:2142) 5'-CrCGGCCCCGCGGCCCGGC'IGCCCGCCCGGCCCGG-3 (FRAG. NO:2132) (SEQ. ID NO:2143) 5'-TCGGCCCCGCGGCCCGGCTTGCCCGCCCGGCCCGG-3' (FRAG. NO:2133) (SEQ. ID NO:2144) 5'-CGGCCCCGCGGCCCGGCTTGCCCGCCCGGCCCGG-3' FRAGG. NO:2134) (SEQ. ID NO:2145) 5'-GGCCCCGCGGCCCGGCTrGCCCGCCCGGCCCGG-3'(FRAG. NO:2135) (SEQ. ID NO:2146) 5'-GCCCCGCGGCCCGGCTTGCCCGCCCGGCCCGG-3'(FRAG. NO:2136) (SEQ. ID NO:2147) 5'-CCCCGCGGCCCGGCTTGCCCGCCCGGCCCGG-3' (FRAG. NO:2137) (SEQ. ID NO:2148) 5'-CCCGCGGCCCGGCTTGCCCGCCCGGCCCGG-3'(FRAG. NO:2138) (SEQ. ID NO:2149) 5'-CCGCGGCCCGGCTTGCCCGCCCGGCCCGG-3' (FRAG. NO:2139) (SEQ. ID NO:2150) 5'-CGCGGCCCGGCTTGCCCGCCCGGCCCGG-3'(FRAG. NO:2140) (SEQ. ID NO:2151) 5'-GCGGCCCGGCTTGCCCGCCCGGCCCGG-3' (FRAG. NO:2141) (SEQ. ID NO:2152) 5'-CGGCCCGGCTTGCCCGCCCGGCCCGG-3' (FRAG. NO:2142) (SEQ. ID NO:2153) 5'-GGCCCGGCTTGCCCGCCCGGCCCGG-3' (FRAG. NO:2143) (SEQ. ID NO:2154) 5'-GCCCGGCTTGCCCGCCCGGCCCGG-3' (FRAG. NO:2144) (SEQ. ID NO:2155) 5'-CCCGGCTGCCCGCCCGGCCCGG-3' (FRAG. NO:2145) (SEQ. ID NO:2156) 5'-CCGGCTTGCCCGCCCGGCCCGG-3' (FRAG. NO:2146) (SEQ. ID NO:2157) 5'-CGGCTTGCCCGCCCGGCCCGG-3' (FRAG. NO:2147) (SEQ. ID NO:2158) 5'-GGCTTGCCCGCCCGGCCCGG-3' (FRAG. NO:2148) (SEQ. ID NO:2159) 5'-GCTTGCCCGCCCGGCCCGG-3' (FRAG. NO:2149) (SEQ. ID NO:2160) 5'-CTTGCCCGCCCGGCCCGG-3' (FRAG. NO:2150) (SEQ. ID NO:2161) 5'-TTGCCCGCCCGGCCCGG-3' (FRAG. NO:2151) (SEQ. ID NO:2162) 5'-TGCCCGCCCGGCCCGG-3' (FRAG. NO:2152) (SEQ. ID NO:2163) 5'-GCCCGCCCGGCCCGG-3' (FRAG. NO:2153) (SEQ. ID NO:2164) 5'-CCCGCCCGGCCCGG-3' (FRAG. NO:2154) (SEQ. ID NO:2165) 5'-CCGCCCGGCCCGG-3'(FRAG. NO:2155) (SEQ. ID NO:2166) 5'-CGCCCGGCCCGG-3' (FRAG. NO:2156) (SEQ. ID NO:2167) 5'-GCCCGGCCCGG-3' (FRAG. NO:2157) (SEQ. ID NO:2168) 5'-GGCGGGGGCGGCGGCGCCTGGCTCGCCTBGGGCCCC-3' (FRAG. NO:2158) (SEQ. ID NO:2169) 5'-GGCGGGGGCGGCGGCGCCTGGCTCGCCTBGGGCCC-3' (FRAG. NO:2159) (SEQ. ID NO:2170) 5'-GGCGGGGGCGGCGGCGCCTGGCTCGCCTBGGGCC-3' (FRAG. NO:2160) (SEQ. ID NO:2171) 5'-GGCGGGGGCGGCGGCGCCTGGCTCGCCTBGGGC-3' (FRAG. NO:2161) (SEQ. ID NO:2172) 5'-GGCGGGGGCGGCGGCGCCTGGCTCGCCTBGGG-3'(FRAG. NO:2162) (SEQ. ID NO:2173) 5'-GGCGGGGGCGGCGGCGCCTGGCTCGCCTBGG-3'(FRAG. NO:2163) (SEQ. ID NO:2174) 5'-GGCGGGGGCGGCGGCGCCTGGCTCGCCTBG-3' (FRAG. NO:2164) (SEQ. ID NO:2175) WO 00/09525 PCT/US99/17712 EPI-109 224 5'-GGCGGGGGCGGCGGCGCCTGGCTCGCCTB-3' (FRAG. NO:2165) (SEQ. ID NO:2176) 5'-GGCGGGGGCGGCGGCGCCTGGCTCGCCT-3' FRAGG. NO:2166) (SEQ. ID NO:2177) 5'-GGCGGGGGCGGCGGCGCCTGGCTCGCC-3' FRAGG. NO:2167) (SEQ. ID NO:2178) 5'-GGCGGGGGCGGCGGCGCCTGGCTCGC-3' (FRAG. NO:2168) (SEQ. ID NO:2179) 5'-GGCGGGGGCGGCGGCGCCTGGCTCG-3' (FRAG. NO:2169) (SEQ. ID NO:2180) 5'-GGCGGGGGCGGCGGCGCCTGGCTC-3' (FRAG. NO:2170) (SEQ. ID NO:2181) 5'-GGCGGGGGCGGCGGCGCCTGGCT-3' (FRAG. NO:2171) (SEQ. ID NO:2082) 5'-GGCGGGGGCGGCGGCGCCTGGC-3' (FRAG. NO:2172) (SEQ. ID NO:2183) 5'-GGCGGGGGCGGCGGCGCCTGG-3' (FRAG. NO:2173) (SEQ. ID NO:2184) 5'-GGCGGGGGCGGCGGCGCCTG-3' (FRAG. NO:2174) (SEQ. ID NO:2185) 5'-GGCGGGGGCGGCGGCGCCT-3' (FRAG. NO:2175) (SEQ. ID NO:2186) 5'-GGCGGGGGCGGCGGCGCC-3' (FRAG. NO:2176) (SEQ. ID NO:2187) 5'-GGCGGGGGCGGCGGCGC-3' (FRAG. NO:2177) (SEQ. ID NO:2188) 5'-GGCGGGGGCGGCGGCG-3' (FRAG. NO:2178) (SEQ. ID NO:2189) 5'-GGCGGGGGCGGCGGC-3' (FRAG. NO:2179) (SEQ. ID NO:2190) 5'-GGCGGGGGCGGCGG-3' (FRAG. NO:2180) (SEQ. ID NO:2191) 5'-GGCGGGGGCGGCG-3' (FRAG. NO:2181) (SEQ. ID NO:2192) 5'-GGCGGGGGCGGC-3' (FRAG. NO:2182) (SEQ. ID NO:2193) 5'-GGCGGGGGCGG-3' (FRAG. NO:2183) (SEQ. ID NO:2194) 5'-GCGGGGGCGGCGGCGCCTGGCTCGCCTBGGGCCCC-3' (FRAG. NO:2184) (SEQ. ID NO:2195) 5'-CGGGGGCGGCGGCGCCTGGCTCGCCTBGGGCCCC-3' (FRAG. NO:2185) (SEQ. ID NO:2196) 5'-GGGGGCGGCGGCGCCTGGCTCGCCTBGGGCCCC-3' (FRAG. NO:2186) (SEQ. ID NO:2197) 5-GGGGCGGCGGCGCCTGGCTCGCCTBGGGCCCC-3' (FRAG. NO:2187) (SEQ. ID NO:2198) 5'-GGGCGGCGGCGCCTGGCTCGCCTBGGGCCCC-3' (FRAG. NO:2188) (SEQ. ID NO:2199) 5'-GGCGGCGGCGCCTGGCTCGCCTBGGGCCCC-3'(FRAG. NO:2189) (SEQ. ID NO:2200) 5'-GCGGCGGCGCCTGGCTCGCCTBGGGCCCC-3'(FRAG. NO:2190) (SEQ. ID NO:2201) 5'-CGGCGGCGCCTGGCTCGCCTBGGGCCCC-3' (FRAG. NO:2191) (SEQ. ID NO:2202) 5 -GGCGGCGCCTGGCTCGCCTBGGGCCCC-3' (FRAG. NO:2192) (SEQ. ID NO:2203) 5-GCGGCGCCTGGCTCGCCTBGGGCCCC-3' (FRAG. NO:2193) (SEQ. ID NO:2204) 5'-CGGCGCCTGGCTCGCCTBGGGCCCC-3' (FRAG. NO:2194) (SEQ. ID NO:2205) 5 -GGCGCCTGGCTCGCCTBGGGCCCC-3' (FRAG. NO:2195) (SEQ. ID NO:2206) 5'-GCGCCTGGCTCGCCTBGGGCCCC-3' (FRAG. NO:2196) (SEQ. ID NO:2207) 5'-CGCCTGGCTCGCCTBGGGCCCC-3' (FRAG. NO:2197) (SEQ. ID NO:2208) 5'-GCCTGGCTCGCCTBGGGCCCC-3' (FRAG. NO:2198) (SEQ. ID NO:2209) 5'-CCTGGCTCGCCTBGGGCCCC-3' (FRAG. NO:2199) (SEQ. ID NO:2210) 5'-CTGGCTCGCCTBGGGCCCC-3' (FRAG. NO:2200) (SEQ. ID NO:221 1) 5'-TGGCTCGCCTBGGGCCCC-3' (FRAG. NO:2201) (SEQ. ID NO:2212) 5'-GGCTCGCCTBGGGCCCC-3' (FRAG. NO:2202) (SEQ. ID NO:2213) 5'-GCTCGCCTBGGGCCCC-3' (FRAG. NO:2203) (SEQ. ID NO:2214) 5'-CTCGCCTBGGGCCCC-3' (FRAG. NO:2204) (SEQ. ID NO:2215) 5'-TCGCCTBGGGCCCC-3' (FRAG. NO:2205) (SEQ. ID NO:2216) 5'-CGCCTBGGGCCCC-3' (FRAG. NO:2206) (SEQ. ID NO:2217) 5-GCCTBGGGCCCC-3'(FRAG. NO:2207) (SEQ. ID NO:2218) 5'-CCTBGGGCCCC-3' (FRAG. NO:2208) (SEQ. ID NO:2219) 5'-CTBGGGCCCC-3' (FRAG. NO:2209) (SEQ. ID NO:2220) 5'-GGGTGGGCBCGGCGGCC-3' (FRAG. NO:2210) (SEQ. ID NO:2221) 5'-GGTCGGCGBBGBGCTCGTCGTGGC-3' (FRAG. NO:2211) (SEQ. ID NO:2222) 5'-GGTCGGCGBBGBGCTCGTCGTGG-3' (FRAG. NO:2212) (SEQ. ID NO:2223) 5'-GGTCGGCGBBGBGCTCGTCGTG-3' (FRAG. NO:2213) (SEQ. ID NO:2224) 5-GGTCGGCGBBGBGCTCGTCGT-3' (FRAG. NO:2214) (SEQ. ID NO:2225) 5'-GGTCGGCGBBGBGCTCGTCG-3' (FRAG. NO:2215) (SEQ. ID NO:2226) 5'-GGTCGGCGBBGBGCTCGTC-3' (FRAG. NO:2216) (SEQ. ID NO:2227) 5 -GGTCGGCGBBGBGCTCGT-3' (FRAG. NO:2217) (SEQ. ID NO:2228) 5 -GGTCGGCGBBGBGCTCG-3' (FRAG. NO:2218) (SEQ. ID NO:2229) 5'-GGTCGGCGBBGBGCTC-3' (FRAG. NO:2219) (SEQ. ID NO:2230) 5-GGTCGGCGBBGBGCT-3' (FRAG. NO:2220) (SEQ. ID NO:2231) 5'-GGTCGGCGBBGBGC-3' (FRAG. NO:2221) (SEQ. ID NO:2232) 5 -GGTCGGCGBBGBG-3' (FRAG. NO:2222) (SEQ. ID NO:2233) 5'-GGTCGGCGBBGB-3' (FRAG. NO:2223) (SEQ. ID NO:2234) 5'-GGTCGGCGBBG-3' (FRAG. NO:2224) (SEQ. ID NO:2235) 5-GTCGGCGBBGBGCTCGTCGTGGC-3' (FRAG. NO:2225) (SEQ. ID NO:2236) 5 -TCGGCGBBGBGCTCGTCGTGGC-3' (FRAG. NO:2226) (SEQ. ID NO:2237) 5 -CGGCGBBGBGCTCGTCGTGGC-3' (FRAG. NO:2227) (SEQ. ID NO:2238) 5 -GGCGBBGBGCTCGTCGTGGC-3' (FRAG. NO:2228) (SEQ. ID NO:2239) 5'-GCGBBGBGCTCGTCGTGGC-3' (FRAG. NO:2229) (SEQ. ID NO:2240) WO 00/09525 PCT/US99/17712 EPI-109 225 5'-CGBBGBGCTCGTCGTGGC-3' (FRAG. NO:2230) (SEQ. ID NO:2241) 5'-GBBGBGCTCGTCGTGGC-3' FRAGG. NO:2231) (SEQ. ID NO:2242) 5'-BBGBGCTCGTCGTGGC-3' (FRAG. NO:2232) (SEQ. ID NO:2243) 5'-BGBGCTCGTCGTGGC-3' (FRAG. NO:2233) (SEQ. ID NO:2244) 5'-GBGCTCGTCGTGGC-3' FRAGG. NO:2234) (SEQ. ID NO:2245) 5'-BGCTCGTCGTGGC-3' (FRAG. NO:2235) (SEQ. ID NO:2246) 5'-GCTCGTCGTGGC-3' (FRAG. NO:2236) (SEQ. ID NO:2247) 5'-CTCGTCGTGGC-3' (FRAG. NO:2237) (SEQ. ID NO:2248) 5'-TCGTCGTGGC-3' (FRAG. NO:2238) (SEQ. ID NO:2249) 5'-GGGGCCCCGCGCCGCCCGCC-3' (FRAG. NO:2239) (SEQ. ID NO:2250) 5'-GGGGCCCCGCGCCGCCCGC-3 (FRAG. NO:2240) (SEQ. ID NO:2251) 5'-GGGGCCCCGCGCCGCCCG-3 (FRAG. NO:2241) (SEQ. ID NO:2252) 5'-GGGGCCCCGCGCCGCCC-3' (FRAG. NO:2242) (SEQ. ID NO:2253) 5'-GGGGCCCCGCGCCGCC-3' (FRAG. NO:2243) (SEQ. ID NO:2254) 5'-GGGGCCCCGCGCCGC-3' (FRAG. NO:2244) (SEQ. ID NO:2255) 5-GGGGCCCCGCGCCG-3' (FRAG. NO:2245) (SEQ. ID NO:2256) 5'-GGGGCCCCGCGCC-3' (FRAG. NO:2246) (SEQ. ID NO:2257) 5'-GGGGCCCCGCGC-3' (FRAG. NO:2247) (SEQ. ID NO:2258) 5'-GGGCCCCGCGCCGCCCGCC-3'(FRAG. NO:2248) (SEQ. ID NO:2259) 5'-GGCCCCGCGCCGCCCGCC-3' (FRAG. NO:2249) (SEQ. ID NO:2260) 5'-GCCCCGCGCCGCCCGCC-3' (FRAG. NO:2250) (SEQ. ID NO:2261) 5'-CCCCGCGCCGCCCGCC-3' (FRAG. NO:2251) (SEQ. ID NO:2262) 5'-CCCGCGCCGCCCGCC-3' (FRAG. NO:2252) (SEQ. ID NO:2263) 5'-CCGCGCCGCCCGCC-3' (FRAG. NO:2253) (SEQ. ID NO:2264) 5'-CGCGCCGCCCGCC-3' (FRAG. NO:2254) (SEQ. ID NO:2265) 5'-GCGCCGCCCGCC-3' (FRAG. NO:2255) (SEQ. ID NO:2266) 5'-CGCCGCCCGCC-3' (FRAG. NO:2256) (SEQ. ID NO:2267) 5'-GCCGCCCGCC-3' (FRAG. NO:2257) (SEQ. ID NO:2268) 5'-GGGGCGCGCGGGGCCGCCGGG-3' (FRAG. NO:2258) (SEQ. ID NO:2269) 5'-GGCGGGGBGCGGCBGGGCCCGGGCCC-3' (FRAG. NO:2259) (SEQ. ID NO:2270) 5'-GGCGCGTCGCCGTCGCCCCBGTCGGGCTCGCGC-3' (FRAG. NO:2260) (SEQ. ID NO:2271) 5'-GCGCGGGCBBCBGCGBGCCGGGCGCG-3'(FRAG. NO:2261) (SEQ. ID NO:2272) 5'-GCGCBCGGGCCCBCCTGCGCGGGC-3' (FRAG. NO:2262) (SEQ. ID NO:2273) 5'-GGGCGGGGTGGGCTGCCCTGCGGCCGCC-3' (FRAG. NO:2263) (SEQ. ID NO:2274) 5'-GGGCTGCTGCGCGGCGGCTCCGGCGA-3' (FRAG. NO:2264) (SEQ. ID NO:2275) 5'-CTCCCGGGCGGGGCCGGGCGCGGGG-3' (FRAG. NO:2265) (SEQ. ID NO:2276) 5'-GGGCTGCCGCGGTCCGGGCCCCTCTTGCCGGCG-3' (FRAG. NO:2266) (SEQ. ID NO:2277) 5'-GCGCTCGCGCCGCTGCCGG-3' (FRAG. NO:2267) (SEQ. ID NO:2278) 5'-GCGCCGCTrGGCCTTGTCGCGGC-3' (FRAG. NO:2268) (SEQ. ID NO:2279) 5'-GCTGCTCCBCGCGCTGG-3' (FRAG. NO:2269) (SEQ. ID NO:2280) 5'-GCCGGBGGCCGGCCBGGTCCCGCG-3' (FRAG. NO:2270) (SEQ. ID NO:2281) 5'-CCCGGCGGCCGGCBGGBBGGGCGGGCTGGGC-3' (FRAG. NO:2271) (SEQ. ID NO:2282) 5'-GTCTCTCCCGCCCCGGCCGCGCG-3'(FRAG. NO:2272) (SEQ. ID NO:2283) 5'-GGGCGTCCGCTCCGGGCCGTCGGG-3 (FRAG. NO:2273) (SEQ. ID NO:2284) 5'-GCGGGCACGCGGCGGCTCTGGCGTCGGC-3' (FRAG. NO:2274) (SEQ. ID NO:2285) Bradykinin Receptor Nucleic Acids and Antisense Oligonucleotide Fragments 5'-GGTGBCBTTG BGCBTGTCGG CGCGGTCCCG TTBBGBGTGG GCCCGCCAGC CCAGCCACTC CACTTGGGGG CGGGTGGCCA GCACGAACAG CACCCAGAGG AAGGGGGGCG GCCCAGAAGG GCAGCCCGCA GGCCAGGATC AGGTCTGCTG CGGCCGGAGA TAATGGCATT CACCACGCGG CGGCCCAGCG CACGCCGCGC ATCCGGCCCG GGTTCTGACC TGCAGCCCCC GTCTCCTTGG CATrCCTGGG CCCCAGTCAC TCCTCTCCCT GCCCCCCTTG CTGGGGCAGG GACGGGGTG BCBTTGBGCB TGTCGGCGCG GTCCCGTTBB GBGTGGGCCC GCCAGCCCAG CCACTCCACT TGGGGGCGGG TGGCCAGCAC GAACAGCACC CAGAGGAAGG GGGGCGGCCC AGAAGGGCAG CCCGCAGGCC AGGATCAGGT CTGCTGCGGC CGGAGATAAT GGCATTCACC ACGCGGCGGC CCAGCGCACG CCGCGCATCC GGCCCGGGTT CTGACCTGCA GCCCCCGTCT CCTTGGCATT CCTGGGCCCC AGTCACTCCT CTCCCTGCCC CCCTTGCTGG GGCAGGGACG GCCGTGTTGT CBGTGGTGCT GCCCGTTTGB GGTBTGGCGC TCCBCCBBTT CCCTITTCTC CTTGTTTTCC GTTTCTCTTG CCGTCTGTGG TT CAGATTCACA AACTGCAGGA CTGGGCAGGG AGCAGACAGT GAGCAAACGC CAGCAGGGCT GCTGTGAATT TGTGTAAGGA TTGAGGGACA GTTGCT1i C AGCATGGGCC CAGGAATGCC AAGGAGACAT CTATGCACGA CCTTGGGAAA TGAGTTGATG TCTCCGGTAA AACACCGGAG ACTAATTCCT GCCCTGCCCA ATITTGCAGG GAGCATGGCT GTGAGGATGG GGTGAACTCA CGCACAGCCA AGGACTCCAA AATCACAACA GCAT'ACTGT TCTTATTTGC TGCCACACCT GAGCCAGCCT GCTCCTrCCC AGGAGTGGAG GAGGCCTGGG GGGAGGGAGA GGAGTGACTG AGCTTCCCTC CCGTGTGTTC TCCGTCCCTG CCCCAGCAAG ACAACTTAGA TCTCCAGGAG AACTGCCATC CAGCITGGT GCAATGGCTG AGTGCACAAG TGAGTTGTTG CCCTGGGTTT CTAATCTA TTCAGCrAGA ACTTTGAAGG ACAAT1CTT GCATTAATAA AGGTTAAGCC CTGAGGGGTC CCTGATAACA ACCTGGAGAC CAGGATTTTA TGGCTCCCCT CACTGATGGA CAAGGAGGTC TGTGCCAAAG AAGAATCCAA TAAGCACATA TTGAGCACTT GCTGTATATG CAGTATTGAG CACTGTAGGC AAGACCCAAG AAAGAGAAGG AGCCATCTCC ATCTTGAAGG AACTCAAAGA CTCAAGTGGG AACGACTGGG CACTGCCACC ACCAGAAAGC TGTTCGACGA GACGGTCGAG CAGGGTGCTG TGGGTGATAT GGACAGCAGA AGGGGGAGAC CAAGGTrCCA GCTCAACCAA TAACTATrGC ACAACCACCT GTCCCTGCCT CAGTTCCCTT TTATGTAACA TGAAGTCGTT WO 00/09525 PCT/US99/1 7712 EPI-109 226 GTGAGGGTTA AAGGCAGTAA CAGGTATAAA GTAC=AGAA AAGCAAAGGG TGCTACGTAC ATGTGAGGCA TCA FrACGCA GACGTAACTG G1GATATGTTr ACTATAAGGA AAAGACACTG AGGTCTAGAA ATAGCTCCGT GGAGCAGAAT CAGTATTGGG AGCCGGTGGC GGTGTGAAGC ACCAGTGTCT GGCACACAGT AGGTGCTCAT TGGCTCCCTI' CCACCTGTCA Y7CCCACCAC CCTGAGGCCC CAACCGCCAC ACACACAGGA GCA7I1rGGAG AGAAGGCCAT GTCTrTCAAAG TCTGATI7GT GATGAGGCAG AGGAAGATAT 7rCTAATCGG TCTGCCCAG AGGATCACAG TGCTGAGACC CCCCACCACC AGCCGGTACC TGGGAAGGGG GAGAGTGCAG GCCTGCT7CAG GGACrT7fCC TGTCTCAGCA ACCAAGGGAT TGflCCTGTC AATCAATGGT T7ArrGGAAG GTGGCCCAGT ATGAGCCCTA GAAGAGTGTG AAAAGGAATG GCAATGGTGT TCACCATCGG CAGTGCCAGG GCAGCACTCA TFTCACT7GAT AAATGAATAT TTAflAGCTG GTFGGAGAGC TAGAACCTGG AGAGCTAGAA CCTGGAGAAC TAGAACCTGG AGGGCTAGAA CCTGGAGAGG CTAGAACCAA GAAGGGCTAG AACCTGGAGG GGCTAGAACC TAGAGAAGCT AAAACCTGAG CTAGAAGCTG GAGGACTAGA ACCTGGAGGG CTGGAATCTG AAGGGCTAGA ACCTGGAGGG CTGGAATCTG GAGAGCTAGA ACCTGGAGGG CTAGAACCTG GAGGGCTAGA ACCTAGAAGG GCTrAGAACCT GGAGGGCTGG AATCTGGAGA GCTAGAACCT GGAGGGCTAG AACCTGGAGG GCTAGAACCT AGAAGGGCrA GAACCTGGAG GGCTAGAACC TGGCAGGT7A GAACCTAGAA GGGCTAGAAC CTGGAGAGCC AGAACCTGGA GGGCTAGAAC CTGGAAGGGC TAGAACC7GT AGAGCTAGAA CATGGAGAGC TAGAACCCGG CAGGCTAGAA CCTGGCAAGC TAGAACCTGG AGGGAATGAA CCTGGAGGGC TAGAACCTGG AGAATGAGAA AAATITACAT GGCAAAGAGC CCATAAATCC TGACCAATCC AACTCTGAAT TrTAAAGCAA AAGCGTGAAA AAAAAGATTC CCTCCIACC CCCAACCCAC TCFIrhCC CACCACCCAC TCTCCTCTGC CTCAGTAAGT ATCTGGAGGA AGAAAACAGG TGAAAGAAGA AGTAAAAACC A'I=AGTA'rr AGTATTAGAA TGAAGTCAAA CTGTGCCACA CATGGTGAAT GAAAAAAAAA AAAAAGAGGC TGTGTTIGT CACACAGGGC AGTCATTCAG CACCAGAGCA CGTGATGGTC TGAGACTCTC 7TAGGAGCAG AGCTCTGCCG CAATGGCCAT GTGGGGATCC ACACCTGGTC TGAGGGGCAA CTGAGTCTGC GGGAGAAGAG CGGCCCTATG CATGGTGTAG ATGCCCTGAT AAAGAACATC TGTCCTGTGA AAGACTCAAT GAGCTGTrAT G'I1GTAAACA GGAAGCA IT CACATCCAAA CGAGAAAATC ATGTAAACAT GTGTCTITC TGTAGAGCAT AATAAATGGA TGAGG'TT= GCAAAAAAAA AAAAAAAAA AAATGATAGA CCGTCAATAA T"F7G TAAAT GCT'ITTAAA ATGAATGC= TAAGCCc3GGT GCAGTGCCTC ACATCTGTAA TCCCAGCACT TFGGAGCCGA GCGGGTGGAT TGTGTGAGGT CAGGAGTTCG AGACCAACCT GGCCAACATG GCAAAACCTC ACT~TCTACC AAAAATACAA AAATrAGCCA GGCATGGTGG CAGGCACCTG TGATCCCAGC TACTCAGGAG GCTGAGACAG GAGAATCGCT TGAACCCGGG AGGCAAGGTr GCAGTGAGCC AAGATrACGC CATTGTACTC CAGCCTGGGT GACAGAGAGA GACTCCGTCT CAAAAAAAAA AAAAAAAAAA AAAAAATTAC GC'FCAAACA CATGATCTCT CACCACTGTr GAAFI=C-1 TCTATGAGCC CAGGAGGGCC TCTCAGAGAG GAAAGCTCCT AGGTCTCCT TrCCCTCTGC AAACTCCCTG CCT'rGAAGGT TCAGAAGGAC TGTGCGTGCT CGITrGCATCC M~GCAAGTG TCCAAACCCT GATCCCAGcT GTGCTFTAGGG GTrCCTGCAA ACCTI=CCA GGTGTrAATr ACCTCCCACT TCA=rCCTG rTACCAACT CAGCTFITG =ITAGTGTG T'I7GAATTCC CTGAACTGAC CGTTGTCTGA TCTCCACCTC CCAACrGAAT TAGGGGAGCT GGG=TCTGG AAACCCAGGT GCCGGGTGT7T GCAGAGTGGC TGAAAGCTGG GATGTGGCAG ATCCGTGGCT ACA'FrCATGC ACACACACAC ACCCACATAC CCACACATGC ACACACACAC ACACACCCGC ACTCACACAC TrGGACATGC ATAGACCACA GUITCCACA CCC17CCTAG ACAGGGGTCA CITGGTATCC TGGAGAGAGT GTGAAGTCCr GGAATGGAAA GAGGGGGGAT TAAGCCCCAC CTCTAGCCAT GGGACTGAGA CAAGTCACCA CCAACCCATC TGCGCCTTGT TrACCTCCTC TGTGAGGCAA GCACAGAGCC CATGCCTGCC CCCCTGGATG GGAGTGATGT GAAACTTGAA GGGCGGTCAG AGCAAGGGTC GGGAATGGAA GGCCCTGGG AAAAAAGGCC =TICAACTA GGGGCACAGA GGAGGCCCTG GGCTGAGAAC FTGACAGCAC CITGTAATrG GTAAGCCAAG CCCGAAGGGA CTGGAAATAC TCAGATGTGT CTGTCTCCCT TATrAGGT7C AAAGTCCCTC AAGACCCTGT CTCCATCACA GTGCTCCAGT CCAGACCCCT CCTCTGAGCT CCAGACCCTG CTGGACCCAA CCAGCCCTAT GGGGTCGCAT CCCCACCTGC CTGGAATCT CCAAAGAACC TCCCCTFAA CAGTTCCAGC C1TAACAGT TCCAGTCTAA ACACATGACC 'IMCTCCTCT AAATCAGCCC CCCATCTCTG CCTIGCAGG AGATGGAAGC CATGACACCT GCCTCGCCCC TGTCCTCACC CCATCCATGT CCAATCAAGC ACTAGGCATG TCAGGTITAC CCTCTAAACT CCTCTGGAAT CCAGTCTCTC AGTCTCCATC ATCCCAGGTC GAAGCTAATG GGCTAACTGG TC=TGCTC CACTCTACCC CCACTrGCAGT CCTGAC'ICC TGAGCAGCAG CCAGGGCCTA ATCGATAT7C ACACCAAGCG CCAACCTGAC TGAGATATCC TCCTGCACCA TCATCCCTCC ACCCTGTF=TA GTTCTGCTCA CCCTCAGTGT TCTCATCAAT AATCCACTCC CCTCACAGGC GCGT~GGGA CCCCATGT~rC TATGCTCTCA CAGGACCTF TGCTrGATr T]TCACTGTAC PTAGGTCAGT TrGCAG~rAT TAAGTGACTG AGCAATGTCT GGCTFCTCCA GTAGACTGTC AGCTCCTAGC CATI7GTATAC CTAGCACCGC TGTGTGGGAG CACGTGACAA ACGTCCAGTG AGTCAGGGAC TCAGCAGTCT CCATITCTCC GCCCTGCTGG AGAATGCGTG TA'I=GGCAA TCCCCAGCCC CTGTGCCATC TAACCATCT17 FFCTTCTCTG TrCAGCCCAG GTGTGGCCTC ACTCACATCC CACTCTGAGT CCAAATGTrC TCTCCCTGGA AGATATCAAT G1CTGTCT GTTCGTGAGG ACTCCGTGCC CACCACGGCC TCTICAGGT GAGTCAAAGG GAT7CCTCAG TrCACTAGTr AGGGGAGGTG GGCAGACACC CTGGAGAACT CCCTGGAAAG CTrCAACTCTC ATGCCCCGGA CAACAGT7GA AGGAACCATG GTGATGTITAA GCCCAAAGAC AAAACCTCTC AGGTGTCCAA GTCCCTGTTG GAATCIrGGG AGCAGAGGGA ATGTTCTGTG GTCTAGAGGA AGAGGGGCTC AGGGAGGAGA AGGGCACATT CCTGG~rG'F ATATG7I7CT ATCTATCCCA GATGAACTTG GAAGTGAAGG GAAGAGAGTT AAACATrAAA GTAAATACCC AGTGGATCAG ACAGCAATGT GCCAGAITrGC C117GGAAACA AAATATCTCC AACACATGGC TGACA1TJGG TGGGAGATCA GAACACCCTA AAGAGAGAAT TTAAGGGGAG GGGGAGGAGG ACCTGAGCCA GAGTAGAAGC AGAGGATAGG GAGATCTG~Fr C~rGGGGACA GCAMfGCAA GAAACAAGGC TGAGGGGTCC ACTCCAACCT CTCCACCCTG CTGCAGGTGC TGCCTATGAT GAAGATGAGC AGATGGCCAT CTCAGCTGGG GCCACAGTGC ACTGGACCTA TAGTrTCCAA TTCCGCACTC AGCAGGCATC 'TFrCTGATGA TCCGATGGCT TCTCAGAGCC AGGGATGGGC CAGGATCCAT CCCCTrGGCT ACTGTCTTGC TGAGAAATM ATAAGCAGCA TCTGGTGCTA TACTTGGTC TCTAGTGAGT TAGCTCATGA AAGATGATAG ACTCrCCAAG CCAGGGGTAT GCAGGAAATG GG=FTCTGT AGCTACAGAA ATGGGGT7GA GGGTrGGACC AAGGGACTAC CCAGGGGAAG TC FrACCTC AGAGGACTCT GGAAAGGAGG CTGCAAGT7 TCATGGGTCA AGAAI17CAGA GCCCAGTAGA GACAGCTT7AT CTCTGTFCCA AGATGTCTGG GGCCTTGGTT GGAAGATrCA AAGGCTAGGA AACCAGGAGC CACCAAAAGC GTAACTGGGG CCAGAGGATC CACI=CAAG GTGGCAAG'r GGTrCCCCCC ATGTGGCTGC TTGAGTATCC TCACATGGCG GCTCACATCC T7CCAAGTAA GCAATGCAAA AGGCCAAGAA AGATGCTGCA AAGATGT7AT GACCTAGCCT CAGAAATCAC ACACCATCCC TGCCACCAT7 AGTAAGAAGT CCAGCCCACG TCCAGGAGAA GAGGAAGCAG A FTCCTCCT7 7TGAAATGAA GAATATCAAG TAATTCGGGG GGCATATGAA AUCCACCACA CACCACAGGG ATCTII1AG AGCATACT~rC TrATACCATC ACTGTAGTTC CTTAAGACTC AGGGGCAAAG CCTCA=TCC T7AGCACCCA GTGAAGACCA CGCTTACTCC CTCACTCAAC CTCTTGCTAC 'rTCCCACCTC TCCTGTCCAA CATCTAGTGT CAC1TCCAG AACATACCAA CAGCTrCCCC AG'FrTGTGC CTCTGCTCAG GCTGT7CCCC CTGCCTGGTC CACTGTCCT C=ICTI'GTC CGGTCAAAAT G~CTTCATC CTCAAGACC CAGCTCTAGA GTCACCTCCA ACCCCIACC CACCAGCCCC CTCTCCAAGT CTGTGTCCCA CAACCCCCCT7 GCTCCCTCCA WO 00/09525 PCTIUS99/1 7712 EPI-109 227 GGGCACCCTC CACCCTCTGG GCCACAG'I7G TCAGGAGTCA GGCAGGGCAG GGGCCGGGTG GTGTCrrcT-r TGTGTrCTTG CACTCAGGGC AGAGCTCAGC ACAGAGCAGA CGCTCAAAAA ACA TFAAAG GATAGAAGCA 'rGAT1rGTG GGTCCCCCAG TCTGGCTCCA GGATGCCAGC CAGCTGCTCC TAGAAGCAAA CGGACITC CTGGGAAATC CCAGAGGTGA TGATCAGTAA T~TCTCCCGT GACTCGTAGT TCAGCTCrTC CTCCATGAGC CTGACTATCA GTGGACCTrC CAGAAAGAGC CCCTI=CVJ TCTCTCACCC ACAGCACAGG GCACTGGGAA AATGCCCAAT GAGTCCTGCC TCTGGGTTGT GCTI1GGACT 'TTrCAGTGTG TC1TCGCATCC ACT=TCAAC TrGAATGTTG CAACAGCCAT GAAAAAAGAA ATGCAAAGCG A-FrCAGGATG AGAGCAATAC CCTACTCCAA AGAAGGCAAC ATAGAAGCTC AGAGAGATCA AGCAA IMGC CCAAGACCAC ACAGCTAGGA GTGGAACTCA TGGCTGTCCA AGCCCCATGC CTCTGCTGAA GGTAGAGATG AATrACAGCA ACAAGTCTAG AAAGGTGCCT GCCCTATGGT CTGTGAGTCT TGCCTAAGAA TGAAAGAGGA GCCAGTGGGT TAAAGATGAG GTCACCAACA ACGGTGGTGT TGGAGMIAC CACTGATAAT AAGGGTGCAA AATGTAAATT ACTAATGTr ATFGAGCCTA GTGCAGTGCG TGGGGCMT7 TGCACATrGT CTCTGATCCC TATGACAACC CTGAGAGGTA GTGG=FIAA CTGCCATGTr ACAGGTGAGG TCATTGTGGT TCAAGGACGT TAAGTAACT7 CCCCAGCGTG ACACGGCTTA TAAGTAAGGC AGCCAGGATG TGAACCCAGT AGGACTATCT GGCTGCAAAG TCCCCACCCC CCTCGCCATC TGTATCCTCC AATCACTf CA GTG=rrGCr GCATAGAAGG TAACGGAAAT CACGATGCCA CAGACTGTCC AGGAAGACAG AAACTAGGCA GATGGGCTGG CCATGGTCTC CAAGCCAGAC TGGAATCTCC AGGTCTGGAA TGATATCATr =TCTC717r AATAAAflAA CTCACCCACC ACACGGCF= GAGAGGCTCA AAGTTGACCA ACTCCCTTGG GAGGGCCCCG G'TGATAAGG AAGGAACGTG AATCCTCCCA TCACGGAAGC TrCAAGGAGG TCAAGG1GTCC AACACJTGAG ATTGTTAGTG CTGT7GGTGG ATACTGGCCA AGGAAATATC CCAGTGGAGC CTCGAGATGA AGAACATGAG GCCCCCGT7 AGAACCAAGG ATCAGAGGGG GCTCTGTAAG ACCCAGGGGA GTCAGGTGCA CTGGAGCGCG GGCATGCAGA AAACAGCCTG AGCTCCACCT CGG=TCTCC TrGTCCTGGC TGG FrGTCCT TAACCCCTGT CTC=FCTGG ACCAG~T= GTCCTrCCCT TGTGACCGCT GAGGGGTAAC AGCCTCIIC CACTTT=I CAGCGCCGAC ATGCTCAATG TCACCTGCA AGGGCCCACT CTTAACGGGA CCITGCCCA GAGCAAATGC CCCCAAGTGG AGTGGCTrGGG CTGGCTCAAC ACCATCCAGC cCCCCMrCCT CTGGGTGCTG YrCGTGCTGG CCACCCTAGA GAACATCT= GTCCTCAGCG TCrGCCT GCACAAGAGC AGCTGCACGG TGGCAGAGAT CrACCTGGGG AACCTGGCCG CAGCAGACCTr GATCCTGGCC TGCGGGCTGC CC'ICTGGGC CATCACCATC TCCAACAACT TCGACTGGCT C1TGGGGAG ACGCTCTGCC GCGTGGTGAA TGCCATTATC TCCATGAACC TGTACAGCAG CATCTG'TrC CTGATGCTGG TGAGCATCGA CCGCTACCTG GCCCTGGTGA AAACCATGTC CATGGGCCGG ATGCGCGGCG TGCGCTGGGC CAAGCTCTAC AGCTrGGTGA TCTGGGGGTG TACGCTGCTC CTGAGCTCAC CCATGCTGGT GT7CCGGACC ATGAAGGAGT ACAGCGATGA GGGCCACAAC GTCACCGCT GTGTCATCAG CTACCCATCC CTCATCTGGG AAGTGTrCAC CAACATGCTC CTGAATGTCG TGGG=TCCT GCTGCCCCTG AGTGTCATCA CCT7CTGCAC GATGCAGATC ATGCAGGTGC TGCGGAACAA CGAGATGCAG AAGTrCAAGG AGATCCAGAC GGAGAGGAGG GCCACGGTGC TAGTCCTGGT TGTGCTGCTG CTA~rCATCA TCTGCTGGCT GCCCTTCCAG ATCAGCACCT TCCTGGATAC GCTGCATCGC CTCGGCATCC TCTCCAGCTG CCAGGACGAG CGCATCATCG ATGTAATCAC ACAGATCGCC TC=TCATGG CCTACAGCAA CAGCTGCCTC AACCCACTGG TGTACGTGAT CGTGGGCAAG CG=~CCGAA AGAAGT=TG GGAGGTGTAC CAGGGAGTGT GCCAGAAAGG GGGCTGCAGG TCAGAACCCA TITCAGATGGA GAACTCCATG GGCACACTGC GGACCTCCAT CTCCGTGGAA CGCCAGAT7C ACAAACTGCA GGACTGGGCA GGGAGCAGAC AcITGAGCAAA CGCCAGCAGG GCTGCTGTGA ATrT7GTGTAA GGATTGAGGG ACAGTrGCrT TTCAGCATGG GCCCAGGAAT GCCAAGGAGA CATCTATGCA CGACCTI'GGG AAATGAGTrG ATGTCTCCGG TAAAACACCG GAGACTAA'IT CCTGCCCTGC CCAA=I1GC AGGGAGCATG GCTGTGAGGA TGGGGTGAAC TCACGCACAG CCAAGGACTC CAAAATCACA ACAGCAYTAC TG'FrC-ITAI7 TGCTGCCACA CCTGAGCCAG CCrGCTCCTT CCCAGGAGTG GAGGAGGCCT GGGGGCAGGG AGAGGAGTGA CTGAGCTFCC CTCCCGTGTG TTCTCCGTCC CTGCCCCAGC AAGACAACI7 AGATCTCCAG GAGAACTGCC ATCCAGC1T GGTGCAATGG CTGAGTGCAC AAGTGAGTrG 7FGCCCTGGG 'IrCTAAT CTATFCAGCT AGAAC1TGA AGGACAA'1 CTrGCATrAA TAAAGGTTAA GCCCTGAGGG GTCCCTGATA ACAACCTGGA GACCAGGA'T TI'ATGGCTCC CCTCACrGAT GGACAAGGAG GTCTGTGCCA AAGAAGAATC CAATAAGCAC ATATTGAGCA =TGCTGTAT ATGCAGTATT GAGCACTGTA GGCAAGAGGG AAGAAAGAGA AGGAGCCATC TCCATCTrGA AGGAACTCAA AGACTCAAGT GGGAACGACT GGGCACTGCC ACCACCAGAA AGCTGTITCGA TGAGACGGTC GAGCAGGGTG CTGTGGGTGA TATGGACAGC AGAAGGGGGA GCCAGGflCC AGCTCACCAA TACTAITGCA CACCACCTGT CCTGCCTC GCCCTrCAAA GATGAGCTGT TCCCGCCGCC ACTCCAGCTC TGGCTTCTGG GCTCCGAGGA GGGGTGGGGA CGGTGGTGAC GGTGGGGACA TCAGGCTGCC CCGCAGTACC AGGGAGCGAC TGAAGTGCCC ATGCCGCTTG CTCCGGAGAA GGTGGGTGCC GGGCAGGGGC TGCTCCAGCC GCCTCACCTC TGCTGGGAGG ACAAACTGTC CCAGCACAGA GGGAGGGAGG GAGGGCAGGC AGCGGGGAGA AG1TICCCTG TGGTCGTGGG GAGTr GAGCTC'TCA ATATITAGT GAAAGCTATA GATGAGGCTC CATAGGGG1AT AAAGCACAGA CACACCTIT CAGAGGG17T GTGGACTCTG GGCAGCCTGT CCATAGACCTr CTGTCCCCAA CTGGCAAGTC AGGAAACTCC AGATrAAGGA GCCCCAATGT GGTTGAACAG CCAGGTGCAC AGATGAGTCA ACCACACAGC CAGGCCAGGG AGGGCCI17CA CTCAAGAGCC TACAGCCAGT TCACAGCCAA GCCAGGGCTA GCGCCAGGCC ACCCATAAAC TGATCTGAGA CTCrT'TTCC CTGTCTCCAT GATGATGGGA TCAGGCrTGA TTGCTGG1T7 GTAGGCTrGT TATGAATCAA GTCACAGGGA AGAGGAGCTG ATGGGCTGGG GGGACGTCCT CTGGCCCTCC TGTCrCTTCC CCAGATCCAC TGGGCCCACT CTTATCTGTT cCTrCTGAA GGAAGGG'I7r TAAGGCTI'CA AAAAAAAATG =IIGAAAGT CCCTGCCCTT TCCAGCTCCT ACCGTCTCAG CCCTGGGAGT GTAAAGTGCT GCAGATAGTT AGTAAGTC= TGAGCAAAAC TGAGAAAGCC AGCCTGAGCC 7rGACATGGG AGAAACCTCC GCCATACATC TCCGAAGAAA CGGCCGCGTG TCTCAGGGGA GCGCAAACAC CCGTACCCAG GAAACAGGAC AGC17CTGCC ACTGTCGCCC T7GGGAGCCG TACGTGGCAT GACAAAGAAA TCCCAGGACT CCGCCrGCCC ACCTc3GCCAC CCTCTGT1TrA CACCTrCCGC GTAAACGCCC ACTGIMACA TCCAAAACTC AGACACAAAA TAACCACCTC AAGAAGATAA ATAATGATAA GAAATAAATG flACGCGAGG CAAA'7TTF CACATGGGGC TrCCCAGGCC AC1TGTGGT CAGCCGGGAG GGACGTI= GCCGTCCCAC GACTCCAACG GGCAGCCGGG CCTACGCAAA CATGGAAATC TrCCAAGAGC CTCCCTGGCC CCCAGGGCTC AGAGGGTGGC AGAGCGGAGA GCGAAGGTGG CCGCAGCCT CCCGGCCCCA CAGCCAGCCT GGCTCCAGCT GGGCAGGAGT GCAGAGCTCA GCTGGAGGCG AGGGGGAAGT GCCCAGGAGG CTGATGACAT CACTACCCAG CCC=CAAAG ATGAGCTGFTr CCCGCCGCCA CTCCAGCTCT GGCTrCTGGG CTCCGAGGAG GGGTGGGGAC GGTGGTGACG GTGGGGACAT CAGGCTGCCC CGCAGTACCA GGGAGCGACT GAAGTGCCCA TGCCG=TGC TCCGGAGAAG GTGGGTGCCG GGCAGGGGCT GCTCCAGCCG CCTCACCTCT GCTGGGAGGA CAAACTGTCC CAGGACAGAG GGAGGGAGGG AGGGCAGGCA GCGGGGAGAA G'TTCCCTGT GGTCGTGGGG AGTTGGGAAA AGTCCCITC CTrCCGGAGG GAGG CAGATrCACA AACTGCAGGA CTGGGCAGGG AGCAGACAGT GAGCAAACGC CAGCAGGGCT GCTGTGAAYr TGTGTAAGGA 'rTGAGGGACA GTTGCT=IC AGCATGGGCC CAGGAATGCC AAGGAGACAT CTATGCACGA C=1TGGGAAA TGAGTTGATG TCTCCGGTAA AACACCGGAG ACTAA7CCT GCCCTGCCCA A'fTTGCAGG GAGCATGGCT GTGAGGATGG GGTGAACTCA CGCACAGCCA AGGACTCCAA AATCACAACA WO 00/09525 PCTIUS99/1 7712 EPI-109 228 GCATFACTGT TCTrAnI7GC TGCCACACCT GAGCCAGCCT GCTCCT7CCC AGGAGTGGAG GAGGCCTGGG GGGAGGGAGA GGAGTGACTG AGCTrCCCTC CCGTGTGTTC TCCGTCCCTG CCCCAGCAAG ACAACTAGA TCTrCCAGGAG AACTGCCATC CAG='~GGT GCAATGGCTG AGTGCACAAG TGAGflGr1TG CCCrGGG Trr C11AATCTA TTCAGCTAGA AC'TGAAGG ACAA'IMCTT G3CATTAATAA AGGTrAAGCC CTGAGGGGTC CCTGATAACA ACCTGGAGAC CAGGATITA TGGCTCCCCT CACTGATGGA CAAGGAGGTC TGTGCCAAAG AAGAATCCAA TAAGCACATA TFTGAGCA=T GCrGTATATG CAGTATrGAG CACTGTAGGC AAGACCCAAG AAAGAGAAGG AGCCATCTCC AT=TGAAGG AAC-TCAAAGA CTCAAGTGGG AACGACTGGG CACTGCCACC ACCAGAAAGC TGI7CGACGA GACG3GTCGAG CAGGGTGCTG TGGGTGATAT GGACAGCAGA AGGGGGAGAC CAAGGTTCCA GCTCAACCAA TAACrATTGC ACAACCACCT GTCCCTGCCT CAGTTCC=~ TrATGTAACA TGAAGTCGT7 GTGAGGGTTA AAGGCAGTAA CAGGTATAAA GTACTTAGAA AAGCAAAGGG TGCTACGTAC ATGTGAGGCA TCAflACGCA GACGTAACTG GGATATGTI7 ACTATAAGGA AAAGACACTG AGGTCTAGAA ATAGCTCCGT GGAGCAGAAT CAGTA'ITGGG AGCCGGTGGC GGTGTGAAGC ACCAGTGTCT GGCACACAGT AGGTGCTCAT TGGCTCCCTF CCACCTGTCA TTCCCACCAC CCTGAGGCCC CAACCGCCAC ACACACAGGA GCA'1GGAG AGAAGGCCAT GTCTITCAAAG TCTGATnTGT GATGAGGCAG AGGAAGATAT T7CrAATCGG TCTTGCCCAG AGGATCACAG TGCTGAGACC CCCCACCACC AGCCGGTACC TGGGAAGGGG GAGAGTGCAG GCCTGCTCAG GGA~rTrFCC TGTCTCAGCA ACCAAGGGAT TGTTCCTGTC AATCAATGGT TTA FrGGAAG GTGGCCCAGT ATGAGCCCTA GAAGAGTGTG AAAAGGAATG GCAATGGTGT TCACCATCGG CAGTGCCAGG GCAGCACTCA T7CACT'rGAT AAATGAATAT ITrA'FAGCTG GTTGGAGAGC TAGAACCTGG AGAGCTAGAA CCTGGAGAAC TAGAACCTGG AGGGCTAGAA CCTGGAGAGG CTAGAACCAA GAAGGGCTAG AACCTGGAGG GGCTAGAACC TAGAGAAGCT AAAACCTGAG CTAGAAGCTG GAGGACTAGA ACCTGGAGGG CTGGAATCTG AAGGGCTAGA ACCTGGAGGG CTGGAATCTG GAGAGCTAGA ACCTGGAGGG CTAGAACCTG GAGGGCTAGA ACCTAGAAGG GCTAGAACCT GGAGGGCTGG AATCTGGAGA GCTAGAACCT GGAGGGCTAG AACCTGGAGG GCTAGAACCT AGAAGGGCTA GAACCTGGAG GGCTAGAACC TGGCAGGY7A GAACCTAGAA GGGCTAGAAC CTGGAGAGCC AGAACCTGGA GGGCTAGAAC CTGGAAGGGC TAGAACCTGT AGAGCTAGAA CATGGAGAGC TAGAACCCGG CAGGCTAGAA CCTGGCAAGC TAGAACCTGG AGGGAATGAA CCTGGAGGGC TAGAACCTGG AGAATGAGAA AAATTACAT GGCAAAGAGC CCATAAATCC TGACCAATCC AACTCTGAAT 'IMAAAGCAA AAGCGTGAAA AAAAAGATTC CCTCCT'rACC CCCAACCCAC TCTIT1TCC CACCACCCAC TCTCCTCTGC CTCAGTAAGT ATCTGGAGGA AGAAAACAGG TGAAAGAAGA AGTAAAAACC ATIAGTATT1 AGTATrAGAA TGAAGTCAAA CTGTGCCACA CATGGTGAAT GAAAAAAAAA AAAAAGAGGC TGTGITIGT CACACAGGGC AGTCAITCAG CACCAGAGCA CGTGATGGTC TGAGACTCTC FrAGGAGCAG AGCTCTGCCG CAATGGCCAT GTGGGGATCC ACACCTGGTC TGAGGGGCAA CTGAGTCTGC GGGAGAAGAG CGGCCCTATG CATGGTGTAG ATGCCCTGAT AAAGAACATC TGTCCTGTGA AAGACTCAAT GAGCTGTTAT GTTGTAAACA GGAAGCA'IT CACATCCAAA CGAGAAAATC ATGTAAACAT GTGTCTI=C TGTAGAGCAT AATAAATGGA TGAGGT1T GCAAAAAAAA AAAAAAAAA AAATGATAGA CCGTCAATAA TIGTrAAAT GCTITT=AAA ATGAATGCTI' TAAGCCGGGT GCAGTGCCTC ACATCTGTAA TCCCAGCACT TrGGAGCCGA GCGGGTGGAT TGTGTGAGGT CAGGAGTTCG AGACCAACCT GGCCAACATG GCAAAACCTC ACTCrCTACC AAAAATACAA AAATrAGCCA GGCATGGTGG CAGGCACCTG TGATCCCAGC TACTCAGGAG GCTGAGACAG GAGAATCGCT TGAACCCGGG AGGCAAGGIT GCAGTGAGCC AAGATTACGC CAT7GTACTC CAGCCTGGGT GACAGAGAGA GACTCCGTCT CAAAAAAAAA AAAAAAAAAA AAAAAATTAC G=ICAAACA CATGATCTCT CACCACTGTr GAATMICTT TCTATGAGCC CAGGAGGGCC TCTCAGAGAG GAAAGCrCCT AGGTCTTCCT TTCCCrCrGC AAACTCCCTG CCTGAAGGT TCAGAAGGAC TGTGCGTGCT CGUFGCATCC M~GCAAGTG TCCAAACCCT GATCCCAGCT GTGCTrAGGG GTTCCrGCAA ACCTlI I ICCA GGTGTrAATl ACCTCCCACr TCA1T7CCTG TITACCAACT CAGCTTG I=rAGTGTG 'TGAATrCC CTGAACTrGAC CG'FrGTCrGA TCTCCACCTC CCAACrGAAT TAGGGGAGCT GGGCTTCTGG AAACCCAGGT GCCGGGTGT7 GCAGAGTGGC TGAAAGCTGG GATGTGGCAG ATCCGTGGCT ACATTCATGC ACACACACAC ACCCACATAC CCACACATGC ACACACACAC ACACACCCGC ACTCACACAC TTGGACATGC ATAGACCACA GC'=CCACA CCCCCAG ACAGGGGTCA CTJGGTATCC TGGAGAGAGT GTGAAGTCCT GGAATGGAAA GAGGGGGGAT TAAGCCCCAC CTCTAGCCAT GGGACTGAGA CAAGTCACCA CCAACCCATC TGCGCCTrGT TrACCTCCTC TGTGAGGCAA GCACAGAGCC CATGCCTGCC CCCCTGGATG GGAGTGATGT GAAA=TGAA GGGCGGTCAG AGCAAGGGTC GGGAATGGAA GGCC=~GGG AAAAAAGGCC CI=CAACTA GGGGCACAGA GGAGGCCCTG GGCTGAGAAC TrGACAGCAC CTIGTAATTG GTAAGCCAAG CCCGAAGGGA CTGGAAATAC TCAGATGTGT CTGTCTCCCT TATTAGGTrC AAAGTCCCTC AAGACCCTGT CTCCATCACA GTGCTCCAGT CCAGACCCCT CCTCTGAGCT CCAGACCCTG CTGGACCCAA CCAGCCCTAT GGGGTCGCAT CCCCACCTGC CTGGAATTCT CCAAAGAACC TCCCCITAA CAG1TCCAGC CrrAACAGT TCCAGTCTAA ACACATGACC TrTCTCCTCT AAATCAGCCC CCCATCTCTG CcTTGCAGG AGATGGAAGC CATGACACCT GCCTCGCCCC TGTCCTCACC CCATCCATGT CCAATCAAGC ACTAGGCATG TCAGG'IMAC CCTCTAAACT CCTCTGGAAT CCAGTCTCTC AGTCTCCATC ATCCCAGGTC GAAGCTAATG GGCTAACTGG TCCTrGCT7C CACTCTACCC CCACTGCAGT CCTGAC'FCC TGAGCAGCAG CCAGGGCCTA ATCGATATC ACACCAAGCG CCAACCrGAC TGAGATATCC TCCTGCACCA TCATCCCTCC ACCCTGT"ITA GTrCTGCTCA CCCTCAGTGT TCTCATCAAT AATCCACTCC CCTCACAGGC GCGMIGGGA CCCCATGTTC TATGCTCTCA CAGGACCI= TGCTGATIT TrCACTGTAC T7AGGTCAGT TTGCAGTrAT TAAGTGACTG AGCAATGTCT GGCrCCA GTAGACTGTC AGCTCCTAGC CATrGTATAC CTAGCACCGC TGTGTGGGAG CACGTGACAA ACGTCCAGTG AGTCAGGGAC TCAGCAGTCT CCATITCTCC GCCCTGCTGG AGAATGCGTG TATIGGCAA TCCCCAGCCC CTGTGCCATC TAACCATC= TrCTITCTCTG TTCAGCCCAG GTGTGGCCTC ACTCACATCC CACTCrGAGT CCAAATG ~rC TCTCCCTrGGA AGATATCAAT GT=CTGTCT GTTCGTGAGG ACTCCGTGCC CACCACGGCC TC'TCAGGT GAGTCAAAGG GA FrCCTCAG TrCACrAG1r AGGGGAGGTG GGCAGACACC CTGGAGAACT CCCTGGAAAG CTCAACTCTC ATGCCCCGGA CAACAGT7GA AGGAACCATG GTGATGTrAA GCCCAAAGAC AAAACCTCTC AGGTGTCCAA GTCCCTGT7G GAATCITGGG AGCAGAGGGA ATGTITCTGTG GTCTAGAGGA AGAGGGGCTC AGGGAGGAGA AGGGCACATT CCTGG FrGTr ATATGMTCT ATCTATCCCA GATGAACMG GAAGTGAAGG GAAGAGAGT7 AAACATrAAA GTAAATACCC AGTGGATCAG ACAGCAATGT GCCAGATTGC C17GGAAACA AAATATCTCC AACACATGGC TGACA1T]GG TGGGAGATCA GAACACCCTA AAGAGAGAAT TTAAGGGGAG GGGGAGGAGG ACCTGAGCCA GAGTAGAAGC AGAGGATAGG GAGATCTGTr CTGGGGACA GCATrTGCAA GAAACAAGGC TGAGGGGTCC ACTCCAACCT CTCCACCCTG CTGCAGGTGC TGCCTATGAT GAAGATGAGC AGATGGCCAT CTCAGCTGGG GCCACAGTGC ACTGGACCTA TAGT~CCAA TCCGCACTC AGCAGGCATC T'I'rCTGATGA TCCGATGGCT TCTCAGAGCC AGGGATGGGC CAGGATCCAT CCC=TJGGCT ACTGTCTTGC TGAGAAAMT ATAAGCAGCA TCTGGTGCTA TAC'1GGTC TCTAGTGAGT TAGCTCATGA AAGATGATAG ACTCTCCAAG CCAGGGGTAT GCAGGAAATG GG=FTCTGT AGCTACAGAA ATGGGGTITGA GGGT7GGACC AAGGGACTAC CCAGGGGAAG TCTTACCT7C AGAGGACTCT GGAAAGGAGG CTGCAAG7I17 TCATGGGTCA AGAATrCAGA GCCCAGTAGA GACAGC'FAT CTCT7CCA AGATGTCTGG GGCC=GGYr GGAAGA'TCA AAGGCTAGGA AACCAGGAGC CACCAAAAGC WO 00/09525 PCT/US99/17712 EPI-109 229 GTAACTGGGG CCAGAGGATC CACTTTCAAG GTGGCAAGTr GGTTCCCCCC ATGTGGCTGC TrGAGTATCC TCACATGGCG GCTCACATCC TTCCAAGTAA GCAATGCAAA AGGCCAAGAA AGATGCTGCA AAGATGTrAT GACCTAGCCT CAGAAATCAC ACACCATCCC TGCCACCATT AGTAAGAAGT CCAGCCCACG TCCAGGAGAA GAGGAAGCAG ATTCCTCCTT TTGAAATGAA GAATATCAAG TAATTCGGGG GGCATATGAA AGCCACCACA CACCACAGGG ATCIT=AG AGCATACTTC TTATACCATC ACTGTAGTTC CTTAAGACTC AGGGGCAAAG CCTCACTTCC TTAGCACCCA GTGAAGACCA CGCTTACTCC CTCACTCAAC CTCTTGCTAC TTCCCACCTC TCCTGTCCAA CATCTAGTGT CACTCCAG AACATACCAA CAGC1CCCC AGTTCTGTGC CTCTGCTCAG GCTGTTCCCC CTGCCTGGTC CACTTGTCCT CCTTCTTGTC CGGTCAAAAT GCTTCTTATC CTTCAAGACC CAGCTCTAGA GTCACCTCCA ACCCCTTACC CACCAGCCCC CTCTCCAAGT CTGTGTCCCA CAACCCCCCT GCTCCCTCCA GGGCACCCTC CACCCTCTGG GCCACAGTTG TCAGGAGTCA GGCAGGGCAG GGGCCGGGTG GTGTCTTCTT TGTGTTCTTG CACTCAGGGC AGAGCTCAGC ACAGAGCAGA CGCTCAAAAA ACATTTAAAG GATAGAAGCA TrGA'TTTGTG GGTCCCCCAG TCTGGCTCCA GGATGCCAGC CAGCTGCTCC TAGAAGCAAA CGGACUITC CTGGGAAATC CCAGAGGTGA TGATCAGTAA TCTCTCCCGT GACTCGTAGT TCAGCTCTTC CTCCATGAGC CTGACTATCA GTGGACCTTC CAGAAAGAGC CCCFI1-CCT TCTCTCACCC ACAGCACAGG GCACTGGGAA AATGCCCAAT GAGTCCTGCC TCTGGGTTGT GCTTTGGACT TTTCAGTGTG TCTCGCATCC ACTCTTCAAC TTGAATGTTG CAACAGCCAT GAAAAAAGAA ATGCAAAGCG ATTCAGGATG AGAGCAATAC CCTACTCCAA AGAAGGCAAC ATAGAAGCTC AGAGAGATCA AGCAATTGC CCAAGACCAC ACAGCTAGGA GTGGAACTCA TGGCTGTCCA AGCCCCATGC CrCTGCTGAA GGTAGAGATG AATTACAGCA ACAAGTCTAG AAAGGTGCCT GCCCTATGGT CTGTGAGTCT TGCCTAAGAA TGAAAGAGGA GCCAGTGGGT TAAAGATGAG GTCACCAACA ACGGTGGTGT TGGAGTTTAC CACTGATAAT AAGGGTGCAA AATGTAAATT ACTAATGTT ATTGAGCCTA GTGCAGTGCG TGGGGCATTT TGCACATTGT CTCTGATCCC TATGACAACC CTGAGAGGTA GTGGTTTAA CTGCCATGTT ACAGGTGAGG TCATTGTGGT TCAAGGACGT TAAGTAACTT CCCCAGCGTG ACACGGCTTA TAAGTAAGGC AGCCAGGATG TGAACCCAGT AGGACTATCT GGCTGCAAAG TCCCCACCCC CCTCGCCATC TGTATCCTCC AATCACTlTCA GTGCTTGCT GCATAGAAGG TAACGGAAAT CACGATGCCA CAGACTGTCC AGGAAGACAG AAACTAGGCA GATGGGCTGG CCATGGTCTC CAAGCCAGAC TGGAATCTCC AGGTCTGGAA TGATATCATT TTrCTC-ITr AATAAATTAA CTCACCCACC ACACGGCTT GAGAGGCTCA AAGTTGACCA ACTCCCTTGG GAGGGCCCCG GTTGATAAGG AAGGAACGTG AATCCTCCCA TCACGGAAGC TTCAAGGAGG TCAAGGGTCC AACACTTGAG ATTGTTAGTG CTGTrGGTGG ATACTGGCCA AGGAAATATC CCAGTGGAGC CTCGAGATGA AGAACATGAG GCCCCCGTTT AGAACCAAGG ATCAGAGGGG GCTCTGTAAG ACCCAGGGGA GTCAGGTGCA CTGGAGCGCG GGCATGCAGA AAACAGCCTG AGCTCCACCT CGGCTCTCC TTGTCCTGGC TGGTTGTCCT TAACCCCTGT CTCCTTCTGG ACCAGTITIT GTCCTTCCCT TGTGACCGCT GAGGGGTAAC AGCCTCTTTC CACTTTCTT CAGCGCCGAC ATGCTCAATG TCACCTTGCA AGGGCCCACT CTrAACGGGA CCTTTGCCCA GAGCAAATGC CCCCAAGTGG AGTGGCTGGG CTGGCTCAAC ACCATCCAGC CCCCCTTCCT CTGGGTGCTG TTCGTGCTGG CCACCCTAGA GAACATCTT GTCCTCAGCG TCTTCTrGCCT GCACAAGAGC AGCTGCACGG TGGCAGAGAT CTACCTGGGG AACCTGGCCG CAGCAGACCT GATCCTGGCC TGCGGGCTGC CCTTCTGGGC CATCACCATC TCCAACAACT TCGACTGGCT C=TTGGGGAG ACGCTCTGCC GCGTGGTGAA TGCCATTATC TCCATGAACC TGTACAGCAG CATCTGTC CTGATGCTGG TGAGCATCGA CCGCTACCTG GCCCTGGTGA AAACCATGTC CATGGGCCGG ATGCGCGGCG TGCGCTGGGC CAAGCTCTAC AGCTTGGTGA TCTGGGGGTG TACGCTGCTC CTGAGCTCAC CCATGCTGGT GTTCCGGACC ATGAAGGAGT ACAGCGATGA GGGCCACAAC GTCACCGCTT GTGTCATCAG CTACCCATCC CTCATCTGGG AAGTGTrCAC CAACATGCTC CTGAATGTCG TGGGCTTCCT GCTGCCCCTG AGTGTCATCA CCTTCTGCAC GATGCAGATC ATGCAGGTGC TGCGGAACAA CGAGATGCAG AAGTrCAAGG AGATCCAGAC GGAGAGGAGG GCCACGGTGC TAGTCCTGGT TGTGCTGCTG CTATTCATCA TCTGCTGGCT GCCCTTCCAG ATCAGCACCT TCCTGGATAC GCTGCATCGC CTCGGCATCC TCTCCAGCTG CCAGGACGAG CGCATCATCG ATGTAATCAC ACAGATCGCC TCCTrCATGG CCTACAGCAA CAGCTGCCTC AACCCACTGG TGTACGTGAT CGTGGGCAAG CGCTTCCGAA AGAAGTCTTG GGAGGTGTAC CAGGGAGTGT GCCAGAAAGG GGGCTGCAGG TCAGAACCCA TTCAGATGGA GAACTCCATG GGCACACTGC GGACCTCCAT CTCCGTGGAA CGCCAGATTC ACAAACTGCA GGACTGGGCA GGGAGCAGAC AGTGAGCAAA CGCCAGCAGG GCTGCTGTGA ATTTGTGTAA GGATTGAGGG ACAGTGCTT TTCAGCATGG GCCCAGGAAT GCCAAGGAGA CATCTATGCA CGACCTTGGG AAATGAGTTG ATGTCTCCGG TAAAACACCG GAGACTAATT CCTGCCCTGC CCAATTGC AGGGAGCATG GCTGTGAGGA TGGGGTGAAC TCACGCACAG CCAAGGACTC CAAAATCACA ACAGCATTAC TGTTCTTATT TGCTGCCACA CCTGAGCCAG CCTGCTCCTT CCCAGGAGTG GAGGAGGCCT GGGGGCAGGG AGAGGAGTGA CTGAGCTTCC CTCCCGTGTG TTCTCCGTCC CTGCCCCAGC AAGACAACTT AGATCTCCAG GAGAACTGCC ATCCAGCTTT GGTGCAATGG CTGAGTGCAC AAGTGAGTTG TTGCCCTGGG TTTCTTTAAT CTATTCAGCT AGAACITGA AGGACAATT CTTGCATTAA TAAAGGTTAA GCCCTGAGGG GTCCCTGATA ACAACCTGGA GACCAGGATr TTATGGCTCC CCTCACTGAT GGACAAGGAG GTCTGTGCCA AAGAAGAATC CAATAAGCAC ATATTGAGCA CTTGCTGTAT ATGCAGTATT GAGCACTGTA GGCAAGAGGG AAGAAAGAGA AGGAGCCATC TCCATCTTGA AGGAACTCAA AGACTCAAGT GGGAACGACT GGGCACTGCC ACCACCAGAA AGCTGTTCGA TGAGACGGTC GAGCAGGGTG CTGTGGGTGA TATGGACAGC AGAAGGGGGA GCCAGGTTCC AGCTCACCAA TACTATTGCA CACCACCTGT CCTGCCTC CTGCAGAAAA CAGCCTGAGC TCCACCTCGG CTTCTCCTTG CCCTGGCTGG TTGTCCTTAA CCCCTGTCTC CTTCTGGACC AGlTIl1GTC CTTCCCTTGT GACCCTGAGG GGTAACAGCC TCTITTCCAC TTCTTCAG CGCCGACATG CTCAATGTCA CCTTGCAAGG GCCCACTCTT AACGGGACCT TTGCCCAGAG CAAATGCCCC CAAGTGGAGT GGCTGGGCTG GCTCAACACC ATCCAGCCCC CCTTCCTCTG GGTGCTGTTC GTGCTGGCCA CCCTAGAGAA CATCTGTC CTCAGCGTCT TCTGCCTGCA CAAGAGCAGC TGCACGGTGG CAGAGATCTA CCTGGGGAAC CTGGCCGCAG CAGACCTGAT CCTGGCCTGC GGGCTGCCCT TCTGGGCCAT CACCATCT'CC AACAACTrCG ACTGGCTCTT TGGGGAGACG CTCTGCCGCG TGGTGAATGC CATTATCTCC ATGAACCTGT ACAGCAGCAT CTGTTTCCTG ATGCTGGTGA GCATCGACCG CTACCTGGCC CTGGTGAAAA CCATGTCCAT GGGCCGGATG CGCGGCGTGC GCTGGGCCAA GCTCTACAGC TTGGTGATCT GGGGGTGTAC GCTGCTCCTG AGCTCACCCA TGCTGGTGTT CCGGACCATG AAGGAGTACA GCGATGAGGG CCACAACGTC ACCGCTTGTG TCATCAGCTA CCCATCCCTC ATCTGGGAAG TGTTCACCAA CATGCTCCTG AATGTCGTGG GCTTCCTGCT GCCCCTGAGT GTCATCACCT TCTGCACGAT GCAGATCATG CAGGTGCTGC GGAACAACGA GATGCAGAAG TTCAAGGAGA TCCAGACGGA GAGGAGGGCC ACGGTGCTAG TCCTGGTTGT GCTGCTGCTA TTCATCATCT GCTGGCTGCC CTTCCAGATC AGCACCTTCC TGGATACGCT GCATCGCCTC GGCATCCTCT CCAGCTGCCA GGACGAGCGC ATCATCGATG TAATCACACA GATCGCCTCC TTCATGGCCT ACAGCAACAG CTGCCTCAAC CCACTGGTGT ACGTGATCGT GGGCAAGCGC TTCCGAAAGA AGTCTTGGGA GGTGTACCAG GGAGTGTGCC AGAAAGGGGG CTGCAGGTCA GAACCCATTC AGATGGAGAA CTCCATGGGC ACACTGCGGA CCTCCATCTC CGTGGAACGC CAGATTCACA AACTGCAGGA CTGGGCAGGG AGCAGACAGT GAGCAAACGC CAGCAGGGCT GCTGTGAATT TGTGTAAGGA TTGAGGGACA GTTGCITITC AGCATGGGCC CAGGAATGCC AAGGAGACAT CTATGCACGA CCTTGGGAAA TGAGTTGATG TCTCCGGTAA AACACCGGAG WO 00/09525 PCT/US99/1 7712 EPI-1 09 230 ACTAATTCCTr GNCCTGCCCA ATITGCAGG GAGCATGGCT GTGAGGATGG GGTGAACTCA CGCACAGCCA AGGACTCCAA AATCACAACA cICATrACTGT T=~ATTTGC TGCCACACCT GAGCCAGCCT GCTrCCT7CCC AGGAGTGGAG GAGGCCTGGG GGCAGGGAGA GGAGTGACTG AG3CTFCCCTC CCGTGTGT7C TCCGTCCCTG CCCCAGCAAG ACAACTTAGA T~CCAGGAG AACTGCCATC CAGCrT=GGT GCAATGGCTG AGTGCACAAG TGAGTT7fG CCCTGGG Tr C TTAATCTA TFCAGCTAGA ACITGAAGG ACAATrCTr GCATTAATAA AGG'TrAAGCC CTGAGGGGTC CCTrGATAACA ACCTGGAGAC CAGGATI=A TGGCTCCCCT CACTGATGGA CAAGGGAGGT CTGTGCCAAA GAAGAATCCA ATAAGCACAT AflGAGCACT TGCTGTATAT GCAGTAT7GA GCACTGTAGG CAAGAGGGAA GAAAGAGAAG GAGCCATCTC CATCYGAAG GAACTCAAAG ACTCAAGTGG GAACGACTGG CACTGCCACC ACCAGAAAGC TGTTCGACGA GACGGTCGAG CAGGcITGCTG TGGGTGATAT GGACAGCAGA AGGGGGAGAC CAAGGTTCCA GCTCAACCAA TAACTA FrGC ACAACCACCT GTCCCTGCCT CAGTrCCCTC ITCTGTAACA TGAAGTCGTT GTGAGGGTTA AAGGCAGTAA CAGGTATAAA GTACTTAGAA AAGCAAAGGG TGCTACGTAC ATGTGAGGCA TCAT7ACGCA GACGTAACTG GGATATGTTr ACTATAAGGA AAAGACACTG AGGTCTAGA TGATCCrATC ACAACCTGAG AGTAGTI ACTCCA'I=A CAGGTGAGGT CATrGTGGfl CAAGGACGTr AAGTAACITrC CCCAGCTCAC ACGGCTrATA AGTAAGGCAG CCAGGATGTG AACCCAGTAG GACTATCTGG CTGCAAAGTC CCCACCCTCC CTCGCCATCT GTATCCTCCA ATCATCT'rCA GTG='~GCT GATAGAAGGT ACGGAAATAC GATGCCACAG ACTGTCCAGG AAGACAGAAA CTAGGCAGAT GGGCTGGCCA TGGTCTCCAA GCCAGACTGG AATCTCCAGG TC7GGAATGA TATCATTIT CTCTI=AAT AAATrAACTC ACCCACCACA CGGC1=GAG AGGCTCAAAG GTGACCAACT CC=TGGGAG GGCCCCGGT7 GATAAGGAAG GAATGTGAAT CCTCCCATCA CGGAAGC'ITC AAGGAGGTCA AGGGTCCAAC A=rGAGAFTr G'ITAGTGCTG TrGGTGGATA CTGCAGAATA TCCAGTGGAG CCTCAGATGA AGAACATGAG GCCCCGTrT7A GATCCAAGGA TCAGAGGGGG CTCTGTAAGA CCCAGGGGAG TCAGGTGCAC TGGAGCGCGG GCTGCAGAAA ACAGCCTGAG CTCCACCTCG GCT7CTCC117 GCC~TGGCTG GTrGTCC'T7A ACCCCTGTCT C=ICTGGAC CAGTfTMGT CCTCCCT7G TGACCTGAGG GGTAACAGCC TCITCCAC TI7CMICAG CGCCGACATG CTCAATGTCA CcTGCAAGG GCCCACTCI AACGGGACT TrGCCCAGAG CAAATGCCCC CAAGTGGAGT GGCTGGGCTG GCTCAACACC ATCCAGCCCC CCT7CCTCrG GGTGCTGT7C GTGCTGGCCA CCCTAGAGAA CATCITGTC CTCAGCGTCT TCTGCCTGCA CAAGAGCAGC TGCACGGTGG CAGAGATCTA CCTGGGGAAC CTGGCCGCAG CAGACCTGAT CCTGGCCTGC GGGCTGCCCT TCTGGGCCAT CACCATCrCC AACAAC'rrCG ACTGGCTCT TGGGGAGACG CTCTGCCGCG TGGTGAATGC CA'ITATCTCC ATGAACCTGT ACAGCAGCAT CTWTTCCTG ATGCTGGTGA GCATCGACCG CTACCTGGCC CTGGTGAAAA CCATGTCCAT GGGCCGGATG CGCGGCGTGC GCTGGGCCAA GCTCTACAGC TTGGTGATCT GGGGGTGTAC GCTGCTCCTG AGCTCACCCA TGCTGGTGTr CCGGACCATG AAGGAGTACA GCGATGAGGG CCACAACGTC ACCG=TGTG TCATCAGCTA CCCATCCCTC ATCTGGGAAG TGTTCACCAA CATGCTCCTG AATGTCGTGG GCTrCCTGCT GCCCCTGAGT GTCATCACCT TCTGCACGAT GCAGATCATG CAGGTGCTGC GGAACAACGA GATGCAGAAG TTCAAGGAGA TCCAGACGGA GAGGAGGGCC ACGGTGCTAG TCCrGG77GT GCTGCTGCTA TrCATCATCT GCTGGCTGCC CT7CCAGATC AGCACCFTCC TGGATACGCT GCATCGCCTC GGCATCCrCT CCAGCTGCCA GGACGAGCGC ATCATCGATG TAATCACACA GATCGCCTCC T7CATGGCCT ACAGCAACAG CTGCCTrCAAC CCACTGGTGT ACGTGATCGT GGGCAAGCGC 'ITCCGAAAGA AGTCTrGGGA GGTGTACCAG GGAGTGTGCC AGAAAGGGGG CTGCAGGTCA GAACCCATrC AGATGGAGAA CTCCATGGGC ACACTGCGGA CCrCCATCTC CGTGGAACGC CAGATTCACA AACrGCAGGA CTGGGCAGGG AGCAGACAGT GAGCAAACGC CAGCAGGGCT GCTGTGAAT7 TGTGTAAGGA TrGAGGGACA GT7GC=TIC AGCATGGGCC CAGGAATGCC AAGGAGACAT CTATGCACGA CTGGGAAA TGAGTGTTGA TGTCTCCGGT AAAACACCGG AGACTAATTC CTGCCCTGCC CAAT=TCGA GGGAGCATGG CTGTGAGGAT GGGGTGAACT CACGCACAGC CAAGGACTCC AAAATCACAA CAGCATrACT G~rCITA'rI GCrGCCACAC CTGAGCCAGC CTGCTCCTC CCAGGAGTGG AGGAGGCCTG GGGGAGGGAG AGGAGTGACT GAGCTTCCCT CCCGTGTGTfl CTCCGTCCCT GCCCCAGCAA GACAAC17AG ATCTCCAGGA GAACTGCCAT CCACGM~GG TGCAATGGCT GAGTGCACAA GTGAGTrrcrr GCCCTGGGTT TC'=AATCT ATCAGCTAGA AC1TGAAGG ACAAM~CTr GCATTAATAA AGGUTAAGCC CTGAGGGGTC C=~GATAAC AACCTGGAGA CCAGGATFF ATGGCTCCCC TCACTGATGG ACAAGGAGGT CTGTGCCAAA GAAGAATCAA TAAGCACATA TGAGCACITC TGTATATCAG TATTGAGCAC TGTAGGCA ATGTTCTCTC CCTGGAAGAT ATCAATGTTI CTFGTCTGTT7 GTGAGGACTC CGTGCCCACC ACGGCCTCT7 TCAGCGCCGA CATGCTCAAT GTCACCTrGC AAGGGCCCAC TCTrAACGGG ACC1=GCCC AGAGCAAATG CCCCCAAGTG GAGTGGCTGG GCTGGCTCAA CACCATCCAG CCCCCCTTCC TCTGGGTGCT GTI'CGTGCTG GCCACCCTAG AGAACATCT7 TG3TCCTCAGC GTCTrCTGCC TGCACAAGAG CAGCTrGCACG GTGGCAGAGA TCTACCTGGG GAACCTGGCC GCAGCAGACC TGATCCTGGC CTGCGGGCTG CCCrGGG CCATCACCAT CTCCAACAAC 'rTCGACTGGC TCTIGGGGA GACGCTCTGC CGCGTGGTGA ATGCCATTAT CTCCATGAAC CTGTACAGCA GCATCTGTr CCTGATGCTG GTGAGCATCG ACCGCTACCT GGCCCTGGTG AAAACCATGT CCATGGGCCG GATGCGCGGC GTGCGCTGGG CCAAGCTCTA CAGCTrGGTG ATCTGGGGGT GTACGCTGCT CCTGAGCTCA CCCATGCTGG TGT'rCCGGAC CATGAAGGAG TACAGCGATG AGGGCCACAA CGTCACCGCT TGTGTCATCA GCTACCCATC CCTCATCTGG GAAGTGTFCA CCAACATGCT CCTGAATGTC GTGGGCTTCC TGCTGCCCCT GAGTGTCATC ACCT1rCTGCA CGATGCAGAT CATGCAGGTG CTcICGGAACA ACGAGATGCA GAAGTrCAAG GAGATCCAGA CGGAGAGGAG GGCCACGGTG CTAGTCCTGG TTGTGCTGCT GCTATTCATC ATCTGCTGGC TGCCCIrCCA GATCAGCACC TrCCTGGATA CGCTGCATCG CCTCGGCATC CTCTCCAGCT GCCAGGACGA GCGCATCATC GATGTAATCA CACAGATCGC CTCCTTCATG GCCTACAGCA ACAGCTGCCT CAACCCACTG GTGTACGTGA TCGTGGGCAA GCGCTCCGA AAGAAGTC~r GGGAGGTGTA CCAGGGAGTG TGCCAGAAAG GGGGCTGCAG GTCAGAACCC ATTCAGATGG AGAACTCCAT GGGCACACTG CGGACCTCCA TCTCCGTGGA ACGCCAGATT CACAAACTrGC AGGACTGGGC AGGGAGCAGA CAGTGAGCAA ACGCCAGCAG GGCTGCTGTG AATTrGTGTA AGGATI'GAGG GACAGTTGCT T ATGTrCTCTC CCTGGAAGAT ATCAATGTr CTGTCTGTrC GTGAGGACTC CGTGCCCACC ACGGCCTCTT TCAGCGCCGA CATGCTCAAT GTCACCrrGC AAGGGCCCAC TC17AACGGG ACC1TGCCC AGAGCAAATG CCCCCAAGTG GAGTGGCTGG GCTGGCTCAA CACCATCCAG CCCCCCTTCC TCTGGGTGCT GT7CGTGCTG GCCACCCTAG AGAACATCT7 TGTCCTCAGC GTCT7CTGCC TGCACAAGAG CAGCTGCACG GTGGCAGAGA TCTACCTGGG GAACCTGGCC GCAGCAGACC TGATCCTGGC CTGCG3GGCTG CCCYITCTGGG CCATCACCAT CTCCAACAAC 7rCGACTGGC TCMTGGGGA GACGCTCTGC CGCGTGGTGA ATGCCATTAT CTCCATGAAC CTGTACAGCA GCATCTGTI CCTGATGCTG GTGAGCATCG ACCGCTFACCT GGCCCTGGTG AAAACCATGT CCATGGGCCG GATGCGCGGC GTGCGCTGGG CCAAGCTCTA CAGCTTGGTG ATCTGGGGGT GTACGCTrGCT CCTGAGCTCA CCCATGCTGG TGTCCGGAC CATGAAGGAG TACAGCGATG AGGGCCACAA CGTCACCGCT TGTGTCATCA GCTACCCATC CCTCATCTGG GAAGTG'TTCA CCAACATGCT CCTGAATGTC GTGGGCTTCC TGCTGCCCCT GAGTGTCATC ACCTTCTGCA CGATGCAGAT CATGCAGGTG CTGCGGAACA ACGAGATGCA GAAGT7CAAG GAGATCCAGA CGGAGAGGAG GGCCACGGTG CTAGTCCTGG TTGTGCTGCT GCTATTCATC ATCTGCTGGC TGCCC=CCA GATCAGCACC TrCCTGGATA CGCTGCATCG CCTCGGCATC CTCTCCAGCT GCCAGGACGA GCGCATCATC GATGTAATCA CACAGATCGC WO 00/09525 PCT/US99/17712 EPI-109 231 CTCCTTCATG GCCTACAGCA ACAGCTGCCT CAACCCACTG GTGTACGTGA TCGTGGGCAA GCGCTTCCGA AAGAAGTCTU GGGAGGTGTA CCAGGGAGTG TGCCAGAAAG GGGGCTGCAG GTCAGAACCC ATTCAGATGG AGAACTCCAT GGGCACACTG CGGACCTCCA TCTCCGTGGA ACGCCAGATT CACAAACTGC AGGACTGGGC AGGGAGCAGA CAGTGAGCAA ACGCCAGCAG GGCTGCTGTG AATTTGTGTA AGGATTGAGG GACAGTTGCT T GCCCTTCAAA GATGAGCTGT TCCCGCCGCC ACTCCAGCTC TGGCTTCTGG GCTCCGAGGA GGGGTGGGGA CGGTGGGGAC ATCAGGCGGC CCCGCAGTAC CAGGGAGCGA CTGAAGTGCC CATGCCGCTT GCTCCGGAGA AGGTGGGTGC CGGGCAGGGG CTGCTCCAGC CGCCTCACCT CTGCTGGGAG GACAAACTGT CCCAGCACAG AGGGAGGGAG GGAGGGCAGG CAGCGGGGAG AAGTCCCT GTGGTCGTGG GGAGTT GCCC=CAAA GATGAGCTGT TCCCGCCGCC ACTCCAGCTC TGGCTTCTGG GCTCCGAGGA GGGGTGGGGA CGGTGGTGAC GGTGGGGACA TCAGGCTGCC CCGCAGTACC AGGGAGCGAC TGAAGTGCCC ATGCCGCTTG CTCCGGAGAA GGTGGGTGCC GGGCAGGGGC TGCTCCAGCC GCCTCACCTC TGCTGGGAGG ACAAACTGTC CCAGCACAGA GGGAGGGAGG GAGGGCAGGC AGCGGGGAGA AGTTTCCCTG TGGTCGTGGG GAGT GAGCTCTTCA ATATITTAGT GAAAGCTATA GATGAGGCTC CATAGGGGAT AAAGCACAGA CACACCITIT CAGAGGGCTT GTGGACTCTG GGCAGCCTGT CCATAGACCT CTGTCCCCAA CTGGCAAGTC AGGAAACTCC AGATTAAGGA GCCCCAATGT GGTTGAACAG CCAGGTGCAC AGATGAGTCA ACCACACAGC CAGGCCAGGG AGGGCCTTCA CTCAAGAGCC TACAGCCAGT TCACAGCCAA GCCAGGGCTA GCGCCAGGCC ACCCATAAAC TGATCTGAGA CTCTGTTTCC CTGTCTCCAT GATGATGGGA TCAGGCTTGA TTGCTGGTIT GTAGGCTTGT TATGAATCAA GTCACAGGGA AGAGGAGCTG ATGGGCTGGG GGGACGTCCT CTGGCCCTCC TGTCTCTTCC CCAGATCCAC TGGGCCCACT CTTATCTGTT CTCTTCTGAA GGAAGGGTTT TAAGGCTTCA AAAAAAAATG TITGAAAGT CCCTGCCC1T TCCAGCTCCT ACCGTCTCAG CCCTGGGAGT GTAAAGTGCT GCAGATAGTT AGTAAGTCTT TGAGCAAAAC TGAGAAAGCC AGCCTGAGCC TTGACATGGG AGAAACCTCC GCCATACATC TCCGAAGAAA CGGCCGCGTG TCTCAGGGGA GCGCAAACAC CCGTACCCAG GAAACAGGAC AGCTTCTGCC ACTGTCGCCC TTGGGAGCCG TACGTGGCAT GACAAAGAAA TCCCAGGACT CCGCCTGCCC ACCTGGCCAC CCTCTGTTrA CACCTTCCGC GTAAACGCCC ACTG1TTACA TCCAAAACTC AGACACAAAA TAACCACCTC AAGAAGATAA ATAATGATAA GAAATAAATG TTACGCGAGG CAAATATT CACATGGGGC TTCCCAGGCC ACTTTGTGGT CAGCCGGGAG GGACGTTTTT GCCGTCCCAC GACTCCAACG GGCAGCCGGG CCTACGCAAA CATGGAAATC TrCCAAGAGC CTCCCTGGCC CCCAGGGCTC AGAGGGTGGC AGAGCGGAGA GCGAAGGTGG CCGCAGCCTT CCCGGCCCCA CAGCCAGCCT GGCTCCAGCT GGGCAGGAGT GCAGAGCTCA GCTGGAGGCG AGGGGGAAGT GCCCAGGAGG CTGATGACAT CACTACCCAG CCCTCAAAG ATGAGCTGTF CCCGCCGCCA CTCCAGCTCT GGCTTCTGGG CTCCGAGGAG GGGTGGGGAC GGTGGTGACG GTGGGGACAT CAGGCTGCCC CGCAGTACCA GGGAGCGACT GAAGTGCCCA TGCCGCTTGC TCCGGAGAAG GTGGGTGCCG GGCAGGGGCT GCTCCAGCCG CCTCACCTCT GCTGGGAGGA CAAACTGTCC CAGCACAGAG GGAGGGAGGG AGGGCAGGCA GCGGGGAGAA GTITCCCTGT GGTCGTGGGG AGTTGGGAAA AGTTCCCTTC CTTCCGGAGG GAGG CAGATTCACA AACTGCAGGA CTGGGCAGGG AGCAGACAGT GAGCAAACGC CAGCAGGGCT GCTGTGAATIT TGTGTAAGGA TTGAGGGACA GTTGCTITTC AGCATGGGCC CAGGAATGCC AAGGAGACAT CTATGCACGA CCTTGGGAAA TGAGTTGATG TCTCCGGTAA AACACCGGAG ACTAATTCCT GCCCTGCCCA ATITTGCAGG GAGCATGGCT GTGAGGATGG GGTGAACTCA CGCACAGCCA AGGACTCCAA AATCACAACA GCATTACTGT TCTTATMTGC TGCCACACCT GAGCCAGCCT GCTCCTTCCC AGGAGTGGAG GAGGCCTGGG GGGAGGGAGA GGAGTGACTG AGCTTCCCTC CCGTGTGTTC TCCGTCCCTG CCCCAGCAAG ACAACTTAGA TCTCCAGGAG AACTGCCATC CAGCTGGT GCAATGGCTG AGTGCACAAG TGAGTTGTTG CCCTGGGTTT CTTTAATCTA TTCAGCTAGA ACTTGAAGG ACAATTTCTr GCATTAATAA AGGTTAAGCC CTGAGGGGTC CCTGATAACA ACCTGGAGAC CAGGATITTA TGGCTCCCCT CACTGATGGA CAAGGAGGTC TGTGCCAAAG AAGAATCCAA TAAGCACATA TTGAGCACTT GCTGTATATG CAGTATTGAG CACTGTAGGC AAGACCCAAG AAAGAGAAGG AGCCATCTCC ATCTTGAAGG AACTCAAAGA CTCAAGTGGG AACGACTGGG CACTGCCACC ACCAGAAAGC TGTTCGACGA GACGGTCGAG CAGGGTGCTG TGGGTGATAT GGACAGCAGA AGGGGGAGAC CAAGGTTCCA GCTCAACCAA TAACTATTGC ACAACCACCT GTCCCTGCCT CAGTrCCCTT TTATGTAACA TGAAGTCGTT GTGAGGGTTA AAGGCAGTAA CAGGTATAAA GTACTTAGAA AAGCAAAGGG TGCTACGTAC ATGTGAGGCA TCATTACGCA GACGTAACTG GGATATGT ACTATAAGGA AAAGACACTG AGGTCTAGAA ATAGCTCCGT GGAGCAGAAT CAGTATTGGG AGCCGGTGGC GGTGTGAAGC ACCAGTGTCT GGCACACAGT AGGTGCTCAT TGGCTCCCTT CCACCTGTCA TTCCCACCAC CCTGAGGCCC CAACCGCCAC ACACACAGGA GCATTTGGAG AGAAGGCCAT GTCTTCAAAG TCTGATTTGT GATGAGGCAG AGGAAGATAT TTCTAATCGG TCrTGCCCAG AGGATCACAG TGCTGAGACC CCCCACCACC AGCCGGTACC TGGGAAGGGG GAGAGTGCAG GCCTGCTCAG GGACTGTTCC TGTCTCAGCA ACCAAGGGAT TGTTCCTGTC AATCAATGGT TTATTGGAAG GTGGCCCAGT ATGAGCCCTA GAAGAGTGTG AAAAGGAATG GCAATGGTGT TCACCATCGG CAGTGCCAGG GCAGCACTCA TTCACTTGAT AAATGAATAT TATTAGCTG GTTGGAGAGC TAGAACCTGG AGAGCTAGAA CCTGGAGAAC TAGAACCTGG AGGGCTAGAA CCTGGAGAGG CTAGAACCAA GAAGGGCTAG AACCTGGAGG GGCTAGAACC TAGAGAAGCT AAAACCTGAG CTAGAAGCTG GAGGACTAGA ACCTGGAGGG CTGGAATCTG AAGGGCTAGA ACCTGGAGGG CTGGAATCTG GAGAGCTAGA ACCTGGAGGG CTAGAACCTG GAGGGCTAGA ACCTAGAAGG GCTAGAACCT GGAGGGCTGG AATCTGGAGA GCTAGAACCT GGAGGGCTAG AACCTGGAGG GCTAGAACCT AGAAGGGCTA GAACCTGGAG GGCTAGAACC TGGCAGGTTA GAACCTAGAA GGGCTAGAAC CTGGAGAGCC AGAACCTGGA GGGCTAGAAC CTGGAAGGGC TAGAACCTGT AGAGCTAGAA CATGGAGAGC TAGAACCCGG CAGGCTAGAA CCTGGCAAGC TAGAACCTGG AGGGAATGAA CCTGGAGGGC TAGAACCTGG AGAATGAGAA AAATTTACAT GGCAAAGAGC CCATAAATCC TGACCAATCC AACTCTGAAT TTrAAAGCAA AAGCGTGAAA AAAAAGATTC CCTCCTTACC CCCAACCCAC TC'ITTITCC CACCACCCAC TCTCCTCTGC CTCAGTAAGT ATCTGGAGGA AGAAAACAGG TGAAAGAAGA AGTAAAAACC A'TTAGTATT AGTATTAGAA TGAAGTCAAA CTGTGCCACA CATGGTGAAT GAAAAAAAAA AAAAAGAGGC TGTG1T1GT CACACAGGGC AGTCATTCAG CACCAGAGCA CGTGATGGTC TGAGACTCTC TTAGGAGCAG AGCTCTGCCG CAATGGCCAT GTGGGGATCC ACACCTGGTC TGAGGGGCAA CTGAGTCTGC GGGAGAAGAG CGGCCCTATG CATGGTGTAG ATGCCCTGAT AAAGAACATC TGTCCTGTGA AAGACTCAAT GAGCTGTTAT GTTGTAAACA GGAAGCATTT CACATCCAAA CGAGAAAATC ATGTAAACAT GTGTCTITIC TGTAGAGCAT AATAAATGGA TGAGGTITT GCAAAAAAAA AAAAAAAAA AAATGATAGA CCGTCAATAA TTGTTAAAT GCITITAAA ATGAATGCTT TAAGCCGGGT GCAGTGCCTC ACATCTGTAA TCCCAGCACT TTGGAGCCGA GCGGGTGGAT TGTGTGAGGT CAGGAGTTCG AGACCAACCT GGCCAACATG GCAAAACCTC ACTCTCTACC AAAAATACAA AAATTAGCCA GGCATGGTGG CAGGCACCTG TGATCCCAGC TACTCAGGAG GCTGAGACAG GAGAATCGCT TGAACCCGGG AGGCAAGGTT GCAGTGAGCC AAGATTACGC CATTGTACTC CAGCCTGGGT GACAGAGAGA GACTCCGTCT CAAAAAAAAA AAAAAAAAAA AAAAAATTAC GCTTCAAACA CATGATCTCT CACCACTGTT GAATTTTCTT TCTATGAGCC CAGGAGGGCC TCTCAGAGAG GAAAGCTCCT AGGTCTTCCT TICCCTCTGC AAACTCCCTG CCTTGAAGGT TCAGAAGGAC TGTGCGTGCT CGTTGCATCC TTGCAAGTG TCCAAACCCT GATCCCAGCT GTGCTTAGGG GTrCCTGCAA ACCTliTCCA GGTGTTAATT ACCTCCCACT TCATTTCCTG TTTACCAACT CAGCITITrG WO 00/09525 PCT/US99/17712 EPI-109 232 TTTTAGTGTG TTGAATTCC CTGAACTGAC CGTrGTCTGA TCTCCACCTC CCAACTGAAT TAGGGGAGCT GGGCTTCrGG AAACCCAGGT GCCGGGTGTT GCAGAGTGGC TGAAAGCTGG GATGTGGCAG ATCCGTGGCT ACATTCATGC ACACACACAC ACCCACATAC CCACACATGC ACACACACAC ACACACCCGC ACTCACACAC TTGGACATGC ATAGACCACA GCTTCCACA CCCTTFCCTAG ACAGGGGTCA CTTGGTATCC TGGAGAGAGT GTGAAGTCCT GGAATGGAAA GAGGGGGGAT TAAGCCCCAC CTCTAGCCAT GGGACTGAGA CAAGTCACCA CCAACCCATC TGCGCCTTGT TTACCTCCTC TGTGAGGCAA GCACAGAGCC CATGCCTGCC CCCCTGGATG GGAGTGATGT GAAACTTGAA GGGCGGTCAG AGCAAGGGTC GGGAATGGAA GGCCCTTGGG AAAAAAGGCC CTTTCAACTA GGGGCACAGA GGAGGCCCTG GGCTGAGAAC TTGACAGCAC CTTGTAATTG GTAAGCCAAG CCCGAAGGGA CTGGAAATAC TCAGATGTGT CTGTCTCCCT TATTAGGTTC AAAGTCCCTC AAGACCCTGT CTCCATCACA GTGCTCCAGT CCAGACCCCT CCTCTGAGCT CCAGACCCTG CTGGACCCAA CCAGCCCTAT GGGGTCGCAT CCCCACCTGC CTGGAATTCT CCAAAGAACC TCCCCITTAA CAGTTCCAGC CITTAACAGT TCCAGTCTAA ACACATGACC TTTCTCCTCT AAATCAGCCC CCCATCTCTG CCTTTGCAGG AGATGGAAGC CATGACACCT GCCTCGCCCC TGTCCTCACC CCATCCATGT CCAATCAAGC ACTAGGCATG TCAGGTAC CCTCTAAACT CCTCTGGAAT CCAGTCTCTC AGTCTCCATC ATCCCAGGTC GAAGCTAATG GGCTAACTGG TCCTTGCTTC CACTCTACCC CCACTGCAGT CCTGACTTCC TGAGCAGCAG CCAGGGCCTA ATCGATATTC ACACCAAGCG CCAACCTGAC TGAGATATCC TCCTGCACCA TCATCCCTCC ACCCTGTTTA GTTCTGCTCA CCCTCAGTGT TCTCATCAAT AATCCACTCC CCTCACAGGC GCGTTTGGGA CCCCATGTTC TATGCTCTCA CAGGACCT TGCTTGATTT TTCACTGTAC TTAGGTCAGT TTGCAGTTAT TAAGTGACTG AGCAATGTCT GGCTTCTCCA GTAGACTGTC AGCTCCTAGC CATTGTATAC CTAGCACCGC TGTGTGGGAG CACGTGACAA ACGTCCAGTG AGTCAGGGAC TCAGCAGTCT CCATTTCTCC GCCCTGCTGG AGAATGCGTG TATTTGGCAA TCCCCAGCCC CTGTGCCATC TAACCATCT TTCTTCTCTG TTCAGCCCAG GTGTGGCCTC ACTCACATCC CACTCTGAGT CCAAATGTTC TCTCCCTGGA AGATATCAAT GTCTGTCT GTTCGTGAGG ACTCCGTGCC CACCACGGCC TCnICAGGT GAGTCAAAGG GATTCCTCAG TTCACTAGTT AGGGGAGGTG GGCAGACACC CTGGAGAACT CCCTGGAAAG CTCAACTCTC ATGCCCCGGA CAACAGTTGA AGGAACCATG GTGATGTTAA GCCCAAAGAC AAAACCTCTC AGGTGTCCAA GTCCCTGTTG GAATCTTGGG AGCAGAGGGA ATGTTCTGTG GTCTAGAGGA AGAGGGGCTC AGGGAGGAGA AGGGCACATT CCTGGTTGTT ATATGITTCT ATCTATCCCA GATGAACTTG GAAGTGAAGG GAAGAGAGTT AAACATTAAA GTAAATACCC AGTGGATCAG ACAGCAATGT GCCAGATTGC CTrGGAAACA AAATATCTCC AACACATGGC TGACA'TTTGG TGGGAGATCA GAACACCCTA AAGAGAGAAT TTAAGGGGAG GGGGAGGAGG ACCTGAGCCA GAGTAGAAGC AGAGGATAGG GAGATCTGTT CTTGGGGACA GCATTGCAA GAAACAAGGC TGAGGGGTCC ACTCCAACCT CTCCACCCTG CTGCAGGTGC TGCCTATGAT GAAGATGAGC AGATGGCCAT CTCAGCTGGG GCCACAGTGC ACTGGACCTA TAGTTTCCAA TTCCGCACTC AGCAGGCATC TTTCTGATGA TCCGATGGCT TCTCAGAGCC AGGGATGGGC CAGGATCCAT CCCCTTGGCT ACTGTCTTGC TGAGAAAT ATAAGCAGCA TCTGGTGCTA TACTTTGGTC TCTAGTGAGT TAGCTCATGA AAGATGATAG ACTCTCCAAG CCAGGGGTAT GCAGGAAATG GGTTTCTGT AGCTACAGAA ATGGGGTITGA GGGTTGGACC AAGGGACTAC CCAGGGGAAG TCTTACCTTC AGAGGACTCT GGAAAGGAGG CTGCAAGTT TCATGGGTCA AGAATTCAGA GCCCAGTAGA GACAGCTTAT CTCTGTTCCA AGATGTCTGG GGCCTTGGTT GGAAGATrCA AAGGCTAGGA AACCAGGAGC CACCAAAAGC GTAACTGGGG CCAGAGGATC CACTTTCAAG GTGGCAAGTT GGTTCCCCCC ATGTGGCTGC TTGAGTATCC TCACATGGCG GCTCACATCC TTCCAAGTAA GCAATGCAAA AGGCCAAGAA AGATGCTGCA AAGATGTTAT GACCTAGCCT CAGAAATCAC ACACCATCCC TGCCACCATT AGTAAGAAGT CCAGCCCACG TCCAGGAGAA GAGGAAGCAG ATTCCTCCTT TTGAAATGAA GAATATCAAG TAATTCGGGG GGCATATGAA AGCCACCACA CACCACAGGG ATCTiT1iAG AGCATACTITC TTATACCATC ACTGTAGTTC C=TAAGACTC AGGGGCAAAG CCTCACTTCC TTAGCACCCA GTGAAGACCA CGCTTACTCC CTCACTCAAC CTCTTGCTAC TTCCCACCTC TCCTGTCCAA CATCTAGTGT CACTTTCCAG AACATACCAA CAGCTTCCCC AGTTCTGTGC CTCTGCTCAG GCTGTTCCCC CTGCCTGGTC CACTTGTCCT CCTTCTTGTC CGGTCAAAAT GCTTCTTATC CTTCAAGACC CAGCTCTAGA GTCACCTCCA ACCCC TTACC CACCAGCCCC CTCTCCAAGT CTGTGTCCCA CAACCCCCCT GCTCCCTCCA GGGCACCCTC CACCCTCTGG GCCACAGTTG TCAGGAGTCA GGCAGGGCAG GGGCCGGGTG GTGTCTTCTT TGTGTTCTTG CACTCAGGGC AGAGCTCAGC ACAGAGCAGA CGCTCAAAAA ACATAAAG GATAGAAGCA TTGATTTGTG GGTCCCCCAG TCTGGCTCCA GGATGCCAGC CAGCTGCTCC TAGAAGCAAA CGGACT ITC CTGGGAAATC CCAGAGGTGA TGATCAGTAA TCTCTCCCGT GACTCGTAGT TCAGCTCTTC CTCCATGAGC CTGACTATCA GTGGACCTC CAGAAAGAGC CCC-I ICCT TCTCTCACCC ACAGCACAGG GCACTGGGAA AATGCCCAAT GAGTCCTGCC TCTGGGTTGT GCTTTGGACT TTTCAGTGTG TCTCGCATCC ACTCTTCAAC TTGAATGTTG CAACAGCCAT GAAAAAAGAA ATGCAAAGCG ATrCAGGATG AGAGCAATAC CCTACTCCAA AGAAGGCAAC ATAGAAGCTC AGAGAGATCA AGCAATTGC CCAAGACCAC ACAGCTAGGA GTGGAACTCA TGGCTGTCCA AGCCCCATGC CTCTGCTGAA GGTAGAGATG AATTACAGCA ACAAGTCTAG AAAGGTGCCT GCCCTATGGT CTGTGAGTCT TGCCTAAGAA TGAAAGAGGA GCCAGTGGGT TAAAGATGAG GTCACCAACA ACGGTGGTGT TGGAGTITAC CACTGATAAT AAGGGTGCAA AATGTAAATT ACTAATG1TT ATTGAGCCTA GTGCAGTGCG TGGGGCATTT TGCACATTGT CTCTGATCCC TATGACAACC CTGAGAGGTA GTGGTITTAA CTGCCATGTT ACAGGTGAGG TCATTGTGGT TCAAGGACGT TAAGTAACTT CCCCAGCGTG ACACGGCTTA TAAGTAAGGC AGCCAGGATG TGAACCCAGT AGGACTATCT GGCTGCAAAG TCCCCACCCC CCTCGCCATC TGTATCCTCC AATCACTTCA GTGC1TGCT GCATAGAAGG TAACGGAAAT CACGATGCCA CAGACTGTCC AGGAAGACAG AAACTAGGCA GATGGGCTGG CCATGGTCTC CAAGCCAGAC TGGAATCTCC AGGTCTGGAA TGATATCATT TT1TCTC1 AATAAATTAA CTCACCCACC ACACGGCIT GAGAGGCTCA AAGTTGACCA ACTCCCTTGG GAGGGCCCCG GTTGATAAGG AAGGAACGTG AATCCTCCCA TCACGGAAGC TTCAAGGAGG TCAAGGGTCC AACACTTGAG ATTGTTAGTG CTGTTGGTGG ATACTGGCCA AGGAAATATC CCAGTGGAGC CTCGAGATGA AGAACATGAG GCCCCCGITT AGAACCAAGG ATCAGAGGGG GCTCTGTAAG ACCCAGGGGA GTCAGGTGCA CTGGAGCGCG GGCATGCAGA AAACAGCCTG AGCTCCACCT CGGCTTCTCC TrGTCCTGGC TGGTTGTCCT TAACCCCTGT CTCCTTCTGG ACCAGrITrI GTCCTTCCCT TGTGACCGCT GAGGGGTAAC AGCCTCTC CACTTT CAGCGCCGAC ATGCTCAATG TCACCTTGCA AGGGCCCACT CTrAACGGGA CCITGCCCA GAGCAAATGC CCCCAAGTGG AGTGGCTGGG CTGGCTCAAC ACCATCCAGC CCCCCTTCCT CTGGGTGCTG TTCGTGCTGG CCACCCTAGA GAACATCTT GTCCTCAGCG TCTCTGCCT GCACAAGAGC AGCTGCACGG TGGCAGAGAT CTACCTGGGG AACCTGGCCG CAGCAGACCT GATCCTGGCC TGCGGGCTGC CCTTCTGGGC CATCACCATC TCCAACAACT TCGACTGGCT CTTGGGGAG ACGCTCTGCC GCGTGGTGAA TGCCATTATC TCCATGAACC TGTACAGCAG CATCTGTTTC CTGATGCTGG TGAGCATCGA CCGCTACCTG GCCCTGGTGA AAACCATGTC CATGGGCCGG ATGCGCGGCG TGCGCTGGGC CAAGCTCTAC AGCTTGGTGA TCTGGGGGTG TACGCTGCTC CTGAGCTCAC CCATGCTGGT GTTCCGGACC ATGAAGGAGT ACAGCGATGA GGGCCACAAC GTCACCGCTT GTGTCATCAG CTACCCATCC CTCATCTGGG AAGTGTTCAC CAACATGCTC CTGAATGTCG TGGGCTTCCT GCTGCCCCTG AGTGTCATCA CCTTCTGCAC GATGCAGATC ATGCAGGTGC TGCGGAACAA CGAGATGCAG AAGTT'CAAGG AGATCCAGAC GGAGAGGAGG GCCACGGTGC TAGTCCTGGT WO 00/09525 PCTIUS99/1 77-12 EPI-109 233 TGTGCTGCTG CTA'ITCATCA TCTGCTGGCT GCCC7rCCAG ATCAGCACCT TCCTGGATAC GCTGCATCGC CTCGGCATCC TCTCCAGCTG CCAGGACGAG CGCATCATCG ATGTAATCAC ACAGATCGCC TC=TCATGG CCTACAGCAA CAGCTGCCTC AACCCACTGG TGTACGTGAT CGTGGGCAAG CGCTTCCGAA AGAAGTC'ITG GGAGGTGTAC CAGGGAGTGT GCCAGAAAGG GGGCTGCAGG TCAGAACCCA TTCAGATGGA GAACTCCATG GGCACACTGC GGACCTCCAT CTCCGTGGAA CGCCAGATTC ACAAACTGCA GGAC1TGGGCA GGGAGCAGAC AGTGAGCAAA CGCCAGCAGG GCTGcTGTGA A TrGTGTAA GGATtGAGGG ACAGTTrGC77 TTCAGCATGG GCCCAGGAAT GCCAAGGAGA CATCTATGCA CGACCT1GGG AAATGAGTTG ATGTCTCCGG TAAAACACCG GAGACTAATr CCTGCCCTGC CCAA1T=GC AGGGAGCATG GCTGTGAGGA TGGGGTGAAC TCACGCACAG CCAAGGACTC CAAAATCACA ACAGCATTAC TGTTrNT7 TGCTGCCACA CcTGAGCCAG CCTGCTCCTT CCCAGGAGTG GAGGAGGCCT GGGGGCAGGG AGAGGAGTGA CTGAGCTTCC CTCCCGTGTG 7rCTCCGTCC CTGCCCCAGC AAGACAACITT AGATCTCCAG GAGAACTGCC ATCCAGCTJ GGTGCAATGG CTGAGTGCAC AAGTGAGYrG TrGCCCTGGG TI1C11AAT CTATrCAGCT AGAACTTGA AGGACAA'IT =TGCAflAA TAAAGGTrAA GCCCTGAGGG GTCCCTrGATA ACAACCTGGA GACCAGGA'r1 TrATGGCTCC CCTCACTGAT GGACAAGGAG GTCTGTGCCA AAGAAGAATC CAATAAGCAC ATATrGAGCA C'ITGCTGTAT ATGCAGTATT GAGCACTGTA GGCAAGAGGG AAGAAAGAGA AGGAGCCATC TCCAT=TGA AGGAACTCAA AGAC1TCAAGT GGGAACGACT GGGCACTGCC ACCACCAGAA AGCTGTrCGA TGAGACGGTC GAGCAGGGTG CTGTGGGTGA TATGGACAGC AGAAGGGGGA GCCAGGTrCC AGCTCACCAA TACTATTGCA CACCACCTGT CCTGCCTC TGATCCTATC ACAACCTGAG AGTAGTTM ACTCCA ITA CAGGTGAGGT CATrGTGGTr CAAGGACGT-f AAG1TAACTTC CCCAGCTCAC ACGGCT1rATA AGTAAGGCAG CCAGGATGTG AACCCAGTAG GACTATCTGG CTGCAAAGTC CCCACCCTCC CI7CGCCATCT GTATCCTrCCA ATCATC77CA GTGCTI7GCT GATAGAAGGT ACGGAAATAC GATGCCACAG ACTGTCCAGG AAGACAGAAA CTAGGCAGAT GGGCTGGCCA TGGTCTCCAA GCCAGACTGG AATCTCCAGG TCTGGAATGA TATCA1TIT CTCTITAAT AAATITAACTC ACCCACCACA CGGCITTGAG AGGCTCAAAG GTGACCAACT CCCTrGGGAG GGCCCCGGTr GATAAGGAAG GAATGTGAAT CCTCCCATCA CGGAAGCTTC AAGGAGGTCA AGGcITCCAAC AC7TGAGATI' G FFAGTGCTG ITGGTGGATA CTGCAGAATA TCCAGTGGAG CCTCAGATGA AGAACATGAG GCCCCGTIT7A GATCCAAGGA TCAGAGGGGG CTCTGTAAGA CCCAGGGGAG TCAGGTGCAC TGGAGCGCGG GCTGCAGAAA ACAGCCTGAG CTCCACCTCG GCTTCTCCTT GCCCTGGCTG GTrGTCC'A ACCCCTGTCT CCTCTGGAC CAGTT=GT CCITCCCTTG TGACCTGAGG GGTAACAGCC TCTI=CCAC nF7=TCAG CGCCGACATG CTCAATGTCA CCrrGCAAGG GCCCACTCT AACGGGACCT TrGCCCAGAG CAAATGCCCC CAAGTGGAGT GGCTGGGCTG GCTCAACACC ATCCAGCCCC CCT7CCTCTG GGTGCTGTI7C GTGCTGGCCA CCCTAGAGAA CATC1TGTC CTCAGCGTCT TCTGCCTGCA CAAGAGCAGC TGCACGGTGG CAGAGATCTA CCTGGGGAAC CTGGCCGCAG CAGACCTGAT CCTGGCCTGC GGGCTGCCCT TCTGGGCCAT CACCATCTCC AACAACTTCG ACTGGCTC17 TGGGGAGACG CTCTGCCGCG TGGTGAATGC CATTATCTCC ATGAACCTGT ACAGCAGCAT CTG'IMCCTG ATGCTGGTGA GCATCGACCG CTACCTGGCC CTGGTGAAAA CCATGTCCAT GGGCCGGATG CGCGGCGTGC GCTGGGCCAA GCTCTACAGC TrGGTGATCT GGGGGTGTAC GCTGCTCCTG AGCTCACCCA TGCTGGTGT7 CCGGACCATG AAGGAGTACA GCGATGAGGG CCACAACGTC ACCGC17GTG TCATCAGCTA CCCATCCCTC ATCrGGGAAG TGTrCACCAA CATGCTCCTG AATGTCGTGG GC'rTCCrGCT GCCCCTGAGT GTCATCACCT TCTGCACGAT GCAGATCATG CAGGTGCTGC GGAACAACGA GATGCAGAAG T7CAAGGAGA TCCAGACGGA GAGGAGGGCC ACGGTGCTAG TCCTGGT-FGT GCTGCTGCrA 'T7CATCATCT GCTGGCTGCC =TCCAGATC AGCACCT7CC TGGATACGCT GCATCGCCTC GGCATCCTCT CCAGCTGCCA GGACGAGCGC ATCATCGATG TAATCACACA GATCGCCTCC 'ITCATGGCCT ACAGCAACAG CTGCCTCAAC CCACTGGTGT ACGTGATCGT GGGCAAGCGC UTCCGAAAGA AGTCITGGGA GGTGTACCAG GGAGTGTGCC AGAAAGGGGG CGCAGGTCA GAACCCArr7C AGATGGAGAA CTCCATGGGC ACACTGCGGA CCTCCATCTC CGTGGAACGC CAGA'I1CACA AACrGCAGGA CTGGGCAGGG AGCAGACAGT GAGCAAACGC CAGCAGGGCT GCTGTGAAT7 TGTGTAAGGA TTGAGGGACA GTrGM'TIC AGCATGGGCC CAGGAATGCC AAGGAGACAT CTATGCACGA CCT7GGGAAA TGAGTGTrGA TGTCTCCGGT AAAACACCGG AGACTAAT7C CTGCCCTGCC CAATITCGA GGGAGCATGG CTGTGAGGAT GGGGTGAACT CACGCACAGC CAAGGACTCC AAAATCACAA CAGCATTACT GTCITATI GCTGCCACAC CTGAGCCAGC CTGCTCCTC CCAGGAGTGG AGGAGGCCTG GGGGAGGGAG AGGAGTGACT GAGCT7CCCT CCCGTGTGTT CTCCGTCCCT GCCCCAGCAA GACAACTTAG ATCTCCAGGA GAACTGCCAT CCACGTrGG TGCAATGGCT GAGTGCACAA GTGAG'rrGTr GCCCTGGG'Fr TC'=AATCT ATCAGCTAGA AC1TGAAGG ACAA'FrrC= GCA'I1rAATAA AGG'FrAAGCC CTGAGGGGTC CC=GATAAC AACCTGGAGA CCAGGATIT ATGGCTCCCC TCACTGATGG ACAAGGAGGT CrGTGCCAAA GAAGAATCAA TAAGCACATA TGAGCACTC TGTATATCAG TATTGAGCAC TGTAGGCA ATGTrCTcTrC CCTGGAAGAT ATCAATGTIT7 CTGTCTGTT GTGAGGACTC CGTGCCCACC ACGGCcTCT TCAGCGCCGA CATGCTCAAT GTCACCTrGC AAGGGCCCAC TCTrAACGGG ACCI=GCCC AGAGCAAATG CCCCCAAGTG GAGTGGCTGG GCTGGCTCAA CACCATCCAG CCCCCCTrCC TCTGGGTGCT GTTCGTGCTG GCCACCCTAG AGAACATCTI' TGTCCTrCAGC GTCUTcGCC TGCACAAGAG CAGCTGCACG GTGGCAGAGA TCTACCTGGG GAACCrGGCC GCAGCAGACC TGATCCTGGC CTGCGGGCTG CCC~rCrGGG CCATCACCAT CTCCAACAAC TTCGACTGGC TCITGGGGA GACGCTCTGC CGCGTGGTGA ATGCCATTAT CTCCATGAAC CTGTACAGCA GCATCTGT7 CCTGATGCTG GTGAGCATCG ACCGCTACCT GGCCCTGGTG AAAACCATGT CCATGGGCCG GATGCGCGGC GTGCGCTGGG CCAAGCTrA CAG=TGGTG ATCTGGGGGT GTACGCT7GCT CCTGAGCTCA CCCATGCTGG TGTTCCGGAC CATGAAGGAG TACAGCGATG AGGGCCACAA CGTCACCGCT TGTGTCATCA GCTACCCATC CCTCATCTGG GAAGTGTrCA CCAACATGCT CCTGAATGTC GTGGGC17CC TGCTGCCCCT GAGTGTCATC ACCrrCTGCA CGATGCAGAT CATGCAGGTG CTGCGGAACA ACGAGATGCA GAAG TTCAAG GAGATCCAGA CGGAGAGGAG GGCCACGGTG CTAGTCCTGG TrGTGCTGCT GC7ATrCATC ATCTGCTGGC TGCCCTTCCA GATCAGCACC T7CCTGGATA CGCTGCATCG C(7rCGGCATC CTCTCCAGCT GCCAGGACGA GCGCATCATC GATGTAATCA CACAGATCGC CTCcrTCATG GCCTACAGCA ACAGCrGCCT CAACCCACTG GTGTACGTGA TCGTGGGCAA GCGCTrCCGA AAGAAGTCT7 GGGAGGTGTA CCAGGGAGTG TGCCAGAAAG GGGGCTGCAG GTCAGAACCC ATTCAGATGG AGAACTCCAT GGGCACACTG CGGACCTCCA TCTCCGTGGA ACGCCAGA'IT CACAAACTGC AGGACTGGGC AGGGAGCAGA CAGTGAGCAA ACGCCAGCAG GGCTGCTGTG ANITTGTGTA AGGATrGAGG GACAGTrGCT T ATGTTCTCTC CCTGGAAcIAT ATCAATG717 CTGTCTGTrC GTGAGGACTC CGTGCCCACC ACGGCCTC= TCAGCGCCGA CATGCTCAAT GTCACCT7GC AAGGGCCCAC TC1rAACGGG ACCITGCCC AGAGCAAATG CCCCCAAGTG GAGTGGCTGG GCTGGCTCAA CACCATCCAG CCCCCCrr7CC TCTGGGTGCT G F7CGTGCTG GCCACCCTAG AGAACATCTT TGTCCTCAGC GTCTGCC TGCACAAGAG CAGCTGCACG GTGGCAGAGA TCTACCTGGG GAACCTGGCC GCAGCAGACC TGATCCTGGC CTGCGGGCTG CC=TCTGGG CCATCACCAT CTCCAACAAC 'ITCGACTGGC T=r~GGGGA GACGCTCTGC CGCGTGGTGA ATGCCATTAT CTCCATGAAC CTGTACAGCA GCATCTG'TrT CCTGATGCTG GTGAGCATCG ACCGCTACCT GGCCCTGGTG AAAACCATGT CCATGGGCCG GATGCGCGGC GTGCGCTGGG CCAAGCTCTA CAGCTGGTG ATCTGGGGGT GTACGCTGCT CCTGAGCTCA CCCATGCTGG TGTrCCGGAC CATGAAGGAG TACAGCGATG AGGGCCACAA WO 00/09525 PCT/US99/17712 EPI-109 234 CGTCACCGCT TGTGTCATCA GCTACCCATC CCTCATCTGG GAAGTGTTCA CCAACATGCT CCTGAATGTC GTGGGCTTCC TGCTGCCCCT GAGTGTCATC ACCTTCTGCA CGATGCAGAT CATGCAGGTG CTGCGGAACA ACGAGATGCA GAAGTrCAAG GAGATCCAGA CGGAGAGGAG GGCCACGGTG CTAGTCCTGG TTGTGCTGCT GCTATTCATC ATCTGCTGGC TGCCCTTrCCA GATCAGCACC 'TCCTGGATA CGCTGCATCG CCTCGGCATC CTCTCCAGCT GCCAGGACGA GCGCATCATC GATGTAATCA CACAGATCGC CTCCTTCATG GCCTACAGCA ACAGCTGCCT CAACCCACTG GTGTACGTGA TCGTGGGCAA GCGCTTCCGA AAGAAGTCTT GGGAGGTGTA CCAGGGAGTG TGCCAGAAAG GGGGCTGCAG GTCAGAACCC ATTCAGATGG AGAACTCCAT GGGCACACTG CGGACCTCCA TCTCCGTGGA ACGCCAGATr CACAAACTGC AGGACTGGGC AGGGAGCAGA CAGTGAGCAA ACGCCAGCAG GGCTGCTGTG AATGTGTA AGGATTGAGG GACAGTTGCT T GCCCTTCAAA GATGAGCTGT TCCCGCCGCC ACTCCAGCTC TGGCTTCTGG GCTCCGAGGA GGGGTGGGGA CGGTGGGGAC ATCAGGCTGC CCCGCAGTAC CAGGGAGCGA CTGAAGTGCC CATGCCGCTT GCTCCGGAGA AGGTGGGTGC CGGGCAGGGG CTGCTCCAGC CGCCTCACCT CTGCTGGGAG GACAAACTGT CCCAGCACAG AGGGAGGGAG GGAGGGCAGG CAGCGGGGAG AAGTTTCCCT GTGGTCGTGG GGAGTT GCCCTTCAAA GATGAGCTGT TCCCGCCGCC ACTCCAGCTC TGGCTTCTGG GCTCCGAGGA GGGGTGGGGA CGGTGGTGAC GGTGGGGACA TCAGGCTGCC CCGCAGTACC AGGGAGCGAC TGAAGTGCCC ATGCCGCTTG CTCCGGAGAA GGTGGGTGCC GGGCAGGGGC TGCTCCAGCC GCCTCACCTC TGCTGGGAGG ACAAACTGTC CCAGCACAGA GGGAGGGAGG GAGGGCAGGC AGCGGGGAGA AGTTTCCCTG TGGTCGTGGG GAGTT GAGCTCTTCA ATATTAGT GAAAGCTATA GATGAGGCTC CATAGGGGAT AAAGCACAGA CACACCTITT CAGAGGGCT GTGGACTCTG GGCAGCCTGT CCATAGACCT CTGTCCCCAA CTGGCAAGTC AGGAAACTCC AGATTAAGGA GCCCCAATGT GGTTGAACAG CCAGGTGCAC AGATGAGTCA ACCACACAGC CAGGCCAGGG AGGGCCTTCA CTCAAGAGCC TACAGCCAGT TCACAGCCAA GCCAGGGCTA GCGCCAGGCC ACCCATAAAC TGATCTGAGA CTCTG7TTCC CTGTCTCCAT GATGATGGGA TCAGGCTTGA TFGCTGGTT GTAGGCTTGT TATGAATCAA GTCACAGGGA AGAGGAGCTG ATGGGCTGGG GGGACGTCCT CTGGCCCTCC TGTCTCT7CC CCAGATCCAC TGGGCCCACT CTTATCTGTT CTCTrCTGAA GGAAGGGT TAAGGCTTCA AAAAAAAATG T=TGAAAGT CCCTGCCCTr TCCAGCTCCT ACCGTCTCAG CCCTGGGAGT GTAAAGTGCT GCAGATAGTT AGTAAGTCTT TGAGCAAAAC TGAGAAAGCC AGCCTGAGCC TTGACATGGG AGAAACCTCC GCCATACATC TCCGAAGAAA CGGCCGCGTG TCTCAGGGGA GCGCAAACAC CCGTACCCAG GAAACAGGAC AGCTTCTGCC ACTGTCGCCC TTGGGAGCCG TACGTGGCAT GACAAAGAAA TCCCAGGACT CCGCCTGCCC ACCTGGCCAC CCTCTG'TTA CACCTTCCGC GTAAACGCCC ACTGTTTACA TCCAAAACTC AGACACAAAA TAACCACCTC AAGAAGATAA ATAATGATAA GAAATAAATG TTACGCGAGG CAAATTTATT CACATGGGGC TrCCCAGGCC ACTTTGTGGT CAGCCGGGAG GGACGTTTTT GCCGTCCCAC GACTCCAACG GGCAGCCGGG CCTACGCAAA CATGGAAATC TCCAAGAGC CTCCCTGGCC CCCAGGGCTC AGAGGGTGGC AGAGCGGAGA GCGAAGGTGG CCGCAGCCTT CCCGGCCCCA CAGCCAGCCT GGCTCCAGCT GGGCAGGAGT GCAGAGCTCA GCTGGAGGCG AGGGGGAAGT GCCCAGGAGG CTGATGACAT CACTACCCAG CCCTTCAAAG ATGAGCTGTr CCCGCCGCCA CTCCAGCTCT GGCTTCTGGG CTCCGAGGAG GGGTGGGGAC GGTGGTGACG GTGGGGACAT CAGGCTGCCC CGCAGTACCA GGGAGCGACT GAAGTGCCCA TGCCGCTTGC TCCGGAGAAG GTGGGTGCCG GGCAGGGGCT GCTCCAGCCG CCTCACCTCT GCTGGGAGGA CAAACTGTCC CAGCACAGAG GGAGGGAGGG AGGGCAGGCA GCGGGGAGAA GICCCTGT GGTCGTGGGG AGTrGGGAAA AGTrCCCTTC CTTCCGGAGG GAGG -3' (FRAG. NO:2275) (SEQ. ID NO:2286) 5'- GAGCTCTTCA ATATTAGT GAAAGCTATA GATGAGGCTC CATAGGGGAT AAAGCACAGA CACACCiTiT CAGAGGGCTT GTGGACTCTG GGCAGCCTGT CCATAGACCT CTGTCCCCAA CTGGCAAGTC AGGAAACTCC AGATTAAGGA GCCCCAATGT GGTTGAACAG CCAGGTGCAC AGATGAGTCA ACCACACAGC CAGGCCAGGG AGGGCCTrCA CTCAAGAGCC TACAGCCAGT TCACAGCCAA GCCAGGGCTA GCGCCAGGCC ACCCATAAAC TGATCTGAGA CTCTGTTTCC CTGTCTCCAT GATGATGGGA TCAGGCTTGA TTGCTGGTTT GTAGGCTTGT TATGAATCAA GTCACAGGGA AGAGGAGCTG ATGGGCTGGG GGGACGTCCT CTGGCCCTCC TGTCTCTTCC CCAGATCCAC TGGGCCCACT CTTATCTGTT CTCTTCTGAA GGAAGGGTTT TAAGGCTCA AAAAAAAATG TTTGAAAGT CCCTGCCCTT TCCAGCTCCT ACCGTCTCAG CCCTGGGAGT GTAAAGTGCT GCAGATAGTT AGTAAGTCTT TGAGCAAAAC TGAGAAAGCC AGCCTGAGCC TTGACATGGG AGAAACCTCC GCCATACATC TCCGAAGAAA CGGCCGCGTG TCTCAGGGGA GCGCAAACAC CCGTACCCAG GAAACAGGAC AGCTTCTGCC ACTGTCGCCC TTGGGAGCCG TACGTGGCAT GACAAAGAAA TCCCAGGACT CCGCCTGCCC ACCTGGCCAC CCTCTGTTTA CACCTTCCGC GTAAACGCCC ACTGTITACA TCCAAAACTC AGACACAAAA TAACCACCTC AAGAAGATAA ATAATGATAA GAAATAAATG TTACGCGAGG CAAATIATT CACATGGGGC TTCCCAGGCC ACTITGTGGT CAGCCGGGAG GGACGTITIT GCCGTCCCAC GACTCCAACG GGCAGCCGGG CCTACGCAAA CATGGAAATC TTCCAAGAGC CTCCCTGGCC CCCAGGGCTC AGAGGGTGGC AGAGCGGAGA GCGAAGGTGG CCGCAGCCTT CCCGGCCCCA CAGCCAGCCT GGCTCCAGCT GGGCAGGAGT GCAGAGCTCA GCTGGAGGCG AGGGGGAAGT GCCCAGGAGG CTGATGACAT CACTACCCAG CCCTTCAAAG ATGAGCTGTT CCCGCCGCCA CTCCAGCTCT GGCTTCTGGG CTCCGAGGAG GGGTGGGGAC GGTGGTGACG GTGGGGACAT CAGGCTGCCC CGCAGTACCA GGGAGCGACT GAAGTGCCCA TGCCGCTTGC TCCGGAGAAG GTGGGTGCCG GGCAGGGGCT GCTCCAGCCG CCTCACCTCT GCTGGGAGGA CAAACTGTCC CAGCACAGAG GGAGGGAGGG AGGGCAGGCA GCGGGGAGAA GTTTCCCTGT GGTCGTGGGG AGTTGGGAAA AGTTCCCTC CTTCCGGAGG GAGG -3' (FRAG. NO:2275) (SEQ. ID NO:2461) 5'- GCCCTTCAAA GATGAGCTGT TCCCGCCGCC ACTCCAGCTC TGGCTCTGG GCTCCGAGGA GGGGTGGGGA CGGTGGTGAC GGTGGGGACA TCAGGCTGCC CCGCAGTACC AGGGAGCGAC TGAAGTGCCC ATGCCGCTTG CTCCGGAGAA GGTGGGTGCC GGGCAGGGGC TGCTCCAGCC GCCTCACCTC TGCTGGGAGG ACAAACTGTC CCAGCACAGA GGGAGGGAGG GAGGGCAGGC AGCGGGGAGA AGTTTCCCTG TGGTCGTGGG GAGTT -3' (FRAG. NO:2275) (SEQ. ID NO:2460) 5'- GCCCFrCAAA GATGAGCTGT TCCCGCCGCC ACTCCAGCTC TGGCTTCTGG GCTCCGAGGA GGGGTGGGGA CGGTGGGGAC ATCAGGCTGC CCCGCAGTAC CAGGGAGCGA CTGAAGTGCC CATGCCGCTT GCTCCGGAGA AGGTGGGTGC CGGGCAGGGG CTGCTCCAGC CGCCTCACCT CTGCTGGGAG GACAAACTGT CCCAGCACAG AGGGAGGGAG GGAGGGCAGG CAGCGGGGAG AAGTTTCCCT GTGGTCGTGG GGAGTT -3' (FRAG. NO:2275) (SEQ. ID NO:2459) 5'- ATGTTCTCTC CCTGGAAGAT ATCAATGTTT CTGTCTGTTC GTGAGGACTC CGTGCCCACC ACGGCCTCTI TCAGCGCCGA CATGCTCAAT GTCACCTTGC AAGGGCCCAC TCTTAACGGG ACCITGCCC AGAGCAAATG CCCCCAAGTG GAGTGGCTGG GCTGGCTCAA CACCATCCAG CCCCCCTTCC TCTGGGTGCT GTTCGTGCTG GCCACCCTAG AGAACATCTT TGTCCTCAGC GTCTTCrGCC TGCACAAGAG CAGCTGCACG GTGGCAGAGA TCTACCTGGG GAACCTGGCC GCAGCAGACC TGATCCTGGC CTGCGGGCTG CCCTTCTGGG CCATCACCAT CTCCAACAAC TTCGACTGGC TCTITGGGGA GACGCTCTGC CGCGTGGTGA ATGCCATTAT CrCCATGAAC CTGTACAGCA GCATCTGT CCTGATGCTG GTGAGCATCG ACCGCTACCT GGCCCTGGTG AAAACCATGT CCATGGGCCG GATGCGCGGC GTGCGCTGGG CCAAGCTCTA CAGCTTGGTG ATCTGGGGGT GTACGCTGCT CCTGAGCTCA CCCATGCTGG TGTTCCGGAC CATGAAGGAG TACAGCGATG AGGGCCACAA CGTCACCGCT TGTGTCATCA WO 00/09525 PCT/US99/17712 EPI-109 235 GCTACCCATC CCTCATCTGG GAAGTGTTCA CCAACATGCT CCTGAATGTC GTGGGCTTCC TGCTGCCCCT GAGTGTCATC ACCTTCTGCA CGATGCAGAT CATGCAGGTG CTGCGGAACA ACGAGATGCA GAAGTTCAAG GAGATCCAGA CGGAGAGGAG GGCCACGGTG CTAGTCCTGG TTrGTGCTGCT GCTAT7CATC ATCTGCTGGC TGCCCTTCCA GATCAGCACC TTCCTGGATA CGCTGCATCG CCTCGGCATC CTCTCCAGCT GCCAGGACGA GCGCATCATC GATGTAATCA CACAGATCGC CTCCTTCATG GCCTACAGCA ACAGCTGCCT CAACCCACTG GTGTACGTGA TCGTGGGCAA GCGCTTCCGA AAGAAGTCTT GGGAGGTGTA CCAGGGAGTG TGCCAGAAAG GGGGCTGCAG GTCAGAACCC ATTCAGATGG AGAACTCCAT GGGCACACTG CGGACCTCCA TCTCCGTGGA ACGCCAGATT CACAAACTGC AGGACTGGGC AGGGAGCAGA CAGTGAGCAA ACGCCAGCAG GGCTGCTGTG AAMTTGTGTA AGGATTGAGG GACAGTTGCT T -3' (FRAG. NO:2275) (SEQ. ID NO:2458) 5'- ATGTTCTCTC CCTGGAAGAT ATCAATGTTT CTGTCTGTT GTGAGGACTC CGTGCCCACC ACGGCCTCTT TCAGCGCCGA CATGCTCAAT GTCACCTTGC AAGGGCCCAC TCTTAACGGG ACCTTTGCCC AGAGCAAATG CCCCCAAGTG GAGTGGCTGG GCTGGCTCAA CACCATCCAG CCCCCC=TCC TCTGGGTGCT GTTCGTGCTG GCCACCCTAG AGAACATCTT TGTCCTCAGC GTCTTCTGCC TGCACAAGAG CAGCTGCACG GTGGCAGAGA TCTACCTGGG GAACCTGGCC GCAGCAGACC TGATCCTGGC CTGCGGGCTG CCCTTCTGGG CCATCACCAT CTCCAACAAC TTICGACTGGC TCTTGGGGA GACGCTCTGC CGCGTGGTGA ATGCCATTAT CTCCATGAAC CTGTACAGCA GCATCTGTTT CCTGATGCTG GTGAGCATCG ACCGCTACCT GGCCCTGGTG AAAACCATGT CCATGGGCCG GATGCGCGGC GTGCGCTGGG CCAAGCTCTA CAGCTGGTG ATCTGGGGGT GTACGCTGCT CCTGAGCTCA CCCATGCTGG TGTTCCGGAC CATGAAGGAG TACAGCGATG AGGGCCACAA CGTCACCGCT TGTGTCATCA GCTACCCATC CCTCATCTGG GAAGTGTTCA CCAACATGCT CCTGAATGTC GTGGGCTTCC TGCTGCCCCT GAGTGTCATC ACCTTCTGCA CGATGCAGAT CATGCAGGTG CTGCGGAACA ACGAGATGCA GAAGTTCAAG GAGATCCAGA CGGAGAGGAG GGCCACGGTG CTAGTCCTGG TTGTGCTGCT GCTATTCATC ATCTGCTGGC TGCCCTTCCA GATCAGCACC TTCCTGGATA CGCTGCATCG CCTCGGCATC CTCTCCAGCT GCCAGGACGA GCGCATCATC GATGTAATCA CACAGATCGC CTCC1TCATG GCCTACAGCA ACAGCTGCCT CAACCCACTG GTGTACGTGA TCGTGGGCAA GCGCTTCCGA AAGAAGTCTT GGGAGGTGTA CCAGGGAGTG TGCCAGAAAG GGGGCTGCAG GTCAGAACCC ATTCAGATGG AGAACTCCAT GGGCACACTG CGGACCTCCA TCTCCGTGGA ACGCCAGATT CACAAACTGC AGGACTGGGC AGGGAGCAGA CAGTGAGCAA ACGCCAGCAG GGCTGCTGTG AATGTGTA AGGATrGAGG GACAGTTGCT T -3' (FRAG. NO:2275) (SEQ. ID NO:2457) 5'- TGATCCTATC ACAACCTGAG AGTAGTIT1- ACTCCATTTA CAGGTGAGGT CATTGTGGTT CAAGGACGTT AAGTAACTC CCCAGCTCAC ACGGCTTATA AGTAAGGCAG CCAGGATGTG AACCCAGTAG GACTATCTGG CTGCAAAGTC CCCACCCTCC CTCGCCATCT GTATCCTCCA ATCATCTTCA GTGCTTTGCT GATAGAAGGT ACGGAAATAC GATGCCACAG ACTGTCCAGG AAGACAGAAA CTAGGCAGAT GGGCTGGCCA TGGTCTCCAA GCCAGACTGG AATCTCCAGG TCTGGAATGA TATCAITIT CTCTTTTAAT AAATTAACTC ACCCACCACA CGGCTTTGAG AGGCTCAAAG GTGACCAACT CCCTTGGGAG GGCCCCGGTT GATAAGGAAG GAATGTGAAT CCTCCCATCA CGGAAGCTTC AAGGAGGTCA AGGGTCCAAC ACTTGAGATT GTTAGTGCTG TTGGTGGATA CTGCAGAATA TCCAGTGGAG CCTCAGATGA AGAACATGAG GCCCCGTA GATCCAAGGA TCAGAGGGGG CTCTGTAAGA CCCAGGGGAG TCAGGTGCAC TGGAGCGCGG GCTGCAGAAA ACAGCCTGAG CTCCACCTCG GCTCTCCTT GCCCTGGCTG GTrGTCCTTA ACCCCTGTCT CCTTCTGGAC CAGITITrGT CCTTCCCTTG TGACCTGAGG GGTAACAGCC TCITlTCCAC TTTCTCAG CGCCGACATG CTCAATGTCA CCTTGCAAGG GCCCACTCTT AACGGGACCT TTGCCCAGAG CAAATGCCCC CAAGTGGAGT GGCTGGGCTG GCTCAACACC ATCCAGCCCC CCTTCCTCTG GGTGCTGTTC GTGCTGGCCA CCCTAGAGAA CATCTGTC CTCAGCGTCT TCTGCCTGCA CAAGAGCAGC TGCACGGTGG CAGAGATCTA CCTGGGGAAC CTGGCCGCAG CAGACCTGAT CCTGGCCTGC GGGCTGCCCT TCTGGGCCAT CACCATCTCC AACAACTTCG ACTGGCTCTT TGGGGAGACG CTCTGCCGCG TGGTGAATGC CATTATCTCC ATGAACCTGT ACAGCAGCAT CTGTTTCCTG ATGCTGGTGA GCATCGACCG CTACCTGGCC CTGGTGAAAA CCATGTCCAT GGGCCGGATG CGCGGCGTGC GCTGGGCCAA GCTCTACAGC TrGGTGATCT GGGGGTGTAC GCTGCTCCTG AGCTCACCCA TGCTGGTGTT CCGGACCATG AAGGAGTACA GCGATGAGGG CCACAACGTC ACCGCTTGTG TCATCAGCTA CCCATCCCTC ATCTGGGAAG TGTTCACCAA CATGCTCCTG AATGTCGTGG GCTTCCTGCT GCCCCTGAGT GTCATCACCT TCTGCACGAT GCAGATCATG CAGGTGCTGC GGAACAACGA GATGCAGAAG TTCAAGGAGA TCCAGACGGA GAGGAGGGCC ACGGTGCTAG TCCTGGTTGT GCTGCTGCTA TTCATCATCT GCTGGCTGCC CTTCCAGATC AGCACCTTCC TGGATACGCT GCATCGCCTC GGCATCCTCT CCAGCTGCCA GGACGAGCGC ATCATCGATG TAATCACACA GATCGCCTCC TTCATGGCCT ACAGCAACAG CTGCCTCAAC CCACTGGTGT ACGTGATCGT GGGCAAGCGC TTCCGAAAGA AGTCTTGGGA GGTGTACCAG GGAGTGTGCC AGAAAGGGGG CTGCAGGTCA GAACCCATTC AGATGGAGAA CTCCATGGGC ACACTGCGGA CCTCCATCTC CGTGGAACGC CAGATTCACA AACTGCAGGA CTGGGCAGGG AGCAGACAGT GAGCAAACGC CAGCAGGGCT GCTGTGAATT TGTGTAAGGA TTGAGGGACA GTTGC111-C AGCATGGGCC CAGGAATGCC AAGGAGACAT CTATGCACGA CCTrGGGAAA TGAGTGTTGA TGTCTCCGGT AAAACACCGG AGACTAATTC CTGCCCTGCC CAATITTCGA GGGAGCATGG CTGTGAGGAT GGGGTGAACT CACGCACAGC CAAGGACTCC AAAATCACAA CAGCATTACT GTTCTrATTT GCTGCCACAC CTGAGCCAGC CTGCTCCTTC CCAGGAGTGG AGGAGGCCTG GGGGAGGGAG AGGAGTGACT GAGCTTCCCT CCCGTGTGTT CTCCGTCCCT GCCCCAGCAA GACAACTTAG ATCTCCAGGA GAACTGCCAT CCACGTGG TGCAATGGCT GAGTGCACAA GTGAGTTGTT GCCCTGGGTT TCTTTAATCT ATCAGCTAGA ACITTGAAGG ACAATTCTT GCATTAATAA AGGTTAAGCC CTGAGGGGTC CCTTGATAAC AACCTGGAGA CCAGGATT ATGGCTCCCC TCACTGATGG ACAAGGAGGT CTGTGCCAAA GAAGAATCAA TAAGCACATA TGAGCACTTC TGTATATCAG TATTGAGCAC TGTAGGCA -3' (FRAG. NO:2275) (SEQ. ID NO:2456) 5'- CTGCAGAAAA CAGCCTGAGC TCCACCTCGG CTTCTCCTTG CCCTGGCTGG TTGTCCTTAA CCCCTGTCTC CTTCTGGACC AGTiTlGTC CTTCCCTTGT GACCCTGAGG GGTAACAGCC TCFITTCCAC TTC'TTTCAG CGCCGACATG CTCAATGTCA CCTTGCAAGG GCCCACTCTf AACGGGACCT TTGCCCAGAG CAAATGCCCC CAAGTGGAGT GGCTGGGCTG GCTCAACACC ATCCAGCCCC CCTTCCTCTG GGTGCTGTTC GTGCTGGCCA CCCTAGAGAA CATC=TTGTC CTCAGCGTCT TCTGCCTGCA CAAGAGCAGC TGCACGGTGG CAGAGATCTA CCTGGGGAAC CTGGCCGCAG CAGACCTGAT CCTGGCCTGC GGGCTGCCCT TCTGGGCCAT CACCATCTCC AACAACTTCG ACTGGCTCT7 TGGGGAGACG CTCTGCCGCG TGGTGAATGC CATTATCTCC ATGAACCTGT ACAGCAGCAT CTGTITCCTG ATGCTGGTGA GCATCGACCG CTACCTGGCC CTGGTGAAAA CCATGTCCAT GGGCCGGATG CGCGGCGTGC GCTGGGCCAA GCTCTACAGC TTGGTGATCT GGGGGTGTAC GCTGCTCCTG AGCTCACCCA TGCTGGTGTT CCGGACCATG AAGGAGTACA GCGATGAGGG CCACAACGTC ACCGCTTGTG TCATCAGCTA CCCATCCCTC ATCTGGGAAG TGTrCACCAA CATGCTCCTG AATGTCGTGG GCTTCCTGCT GCCCCTGAGT GTCATCACCT TCTGCACGAT GCAGATCATG CAGGTGCTGC GGAACAACGA GATGCAGAAG TTCAAGGAGA TCCAGACGGA GAGGAGGGCC ACGGTGCTAG TCCTGGTTGT GCTGCTGCTA T7CATCATCT GCTGGCTGCC CTCCAGATC AGCACCTTCC TGGATACGCT GCATCGCCTC GGCATCCTCT CCAGCTGCCA GGACGAGCGC ATCATCGATG TAATCACACA GATCGCCTCC TTCATGGCCT ACAGCAACAG WO 00/09525 PCT/US99/17712 EPI-109 236 CTGCCTCAAC CCACTGGTGT ACGTGATCGT GGGCAAGCGC TTCCGAAAGA AGTCTrGGGA GGTGTACCAG GGAGTGTGCC AGAAAGGGGG CTGCAGGTCA GAACCCATTC AGATGGAGAA CTCCATGGGC ACACTGCGGA CCTCCATCTC CGTGGAACGC CAGATTCACA AACTGCAGGA CTGGGCAGGG AGCAGACAGT GAGCAAACGC CAGCAGGGCT GCTGTGAATT TGTGTAAGGA TrGAGGGACA GTTGCTITIC AGCATGGGCC CAGGAATGCC AAGGAGACAT CTATGCACGA CCTTGGGAAA TGAGTTGATG TCTCCGGTAA AACACCGGAG ACTAATTCCT GNCCTGCCCA ATTTTGCAGG GAGCATGGCT GTGAGGATGG GGTGAACTCA CGCACAGCCA AGGACTCCAA AATCACAACA GCATrACTGT TCTTATITGC TGCCACACCT GAGCCAGCCT GCTCCTTCCC AGGAGTGGAG GAGGCCTGGG GGCAGGGAGA GGAGTGACTG AGCTTCCCTC CCGTGTGTTC TCCGTCCCTG CCCCAGCAAG ACAACTTAGA TCTCCAGGAG AACTGCCATC CAGCTTGGT GCAATGGCTG AGTGCACAAG TGAGTTGTTG CCCTGGGTTT CTAATCTA TTCAGCTAGA ACTTGAAGG ACAATCTT GCATTAATAA AGGTTAAGCC CTGAGGGGTC CCTGATAACA ACCTGGAGAC CAGGA-TI A TGGCTCCCCT CACTGATGGA CAAGGGAGGT CTGTGCCAAA GAAGAATCCA ATAAGCACAT ATTGAGCACT TGCTGTATAT GCAGTATTGA GCACTGTAGG CAAGAGGGAA GAAAGAGAAG GAGCCATCTC CATCTTGAAG GAACTCAAAG ACTCAAGTGG GAACGACTGG CACTGCCACC ACCAGAAAGC TGTTCGACGA GACGGTCGAG CAGGGTGCrG TGGGTGATAT GGACAGCAGA AGGGGGAGAC CAAGGTTCCA GCTCAACCAA TAACTATTGC ACAACCACCT GTCCCTGCCT CAGTTCCCTC TTCTGTAACA TGAAGTCGTT GTGAGGGTTA AAGGCAGTAA CAGGTATAAA GTACTTAGAA AAGCAAAGGG TGCTACGTAC ATGTGAGGCA TCATTACGCA GACGTAACTG GGATATGTTT ACTATAAGGA AAAGACACTG AGGTCTAGA -3' (FRAG. NO:2275) (SEQ. ID NO:2455) 5'- AAATGATAGA CCGTCAATAA TTGTTAAAT GCTIT AAA ATGAATGCTT TAAGCCGGGT GCAGTGCCTC ACATCTGTAA TCCCAGCACT TTGGAGCCGA GCGGGTGGAT TGTGTGAGGT CAGGAGTTCG AGACCAACCT GGCCAACATG GCAAAACCTC ACTCTCTACC AAAAATACAA AAATTAGCCA GGCATGGTGG CAGGCACCTG TGATCCCAGC TACTCAGGAG GCTGAGACAG GAGAATCGCT TGAACCCGGG AGGCAAGGTT GCAGTGAGCC AAGATrACGC CATTGTACTC CAGCCTGGGT GACAGAGAGA GACTCCGTCT CAAAAAAAAA AAAAAAAAAA AAAAAATTAC GCTTCAAACA CATGATCTCT CACCACTGTT GAA=TTT TCTATGAGCC CAGGAGGGCC TCTCAGAGAG GAAAGCTCCT AGGTCTTCCT TTCCCTCTGC AAACTCCCTG CCTTGAAGGT TCAGAAGGAC TGTGCGTGCT CGTTGCATCC TTTGCAAGTG TCCAAACCCT GATCCCAGCT GTGCTTAGGG GTTCCTGCAA ACCTTCCA GGTGTTAATT ACCTCCCACT TCATTTCCTG TTTACCAACT CAGClITiiG TTTTAGTGTG TTGAATTCC CTGAACTGAC CGTTGTCTGA TCTCCACCTC CCAACTGAAT TAGGGGAGCT GGGCTTCTGG AAACCCAGGT GCCGGGTGTT GCAGAGTGGC TGAAAGCTGG GATGTGGCAG ATCCGTGGCT ACATTCATGC ACACACACAC ACCCACATAC CCACACATGC ACACACACAC ACACACCCGC ACTCACACAC TTGGACATGC ATAGACCACA GCTTTCCACA CCCTTCCTAG ACAGGGGTCA CITGGTATCC TGGAGAGAGT GTGAAGTCCT GGAATGGAAA GAGGGGGGAT TAAGCCCCAC CTCTAGCCAT GGGACTGAGA CAAGTCACCA CCAACCCATC TGCGCCTTGT TTACCTCCTC TGTGAGGCAA GCACAGAGCC CATGCCTGCC CCCCTGGATG GGAGTGATGT GAAACTTGAA GGGCGGTCAG AGCAAGGGTC GGGAATGGAA GGCCCTTGGG AAAAAAGGCC CT=TCAACTA GGGGCACAGA GGAGGCCCTG GGCTGAGAAC TTGACAGCAC CTTGTAATTG GTAAGCCAAG CCCGAAGGGA CTGGAAATAC TCAGATGTGT CTGTCTCCCT TATTAGGTTC AAAGTCCCTC AAGACCCTGT CTCCATCACA GTGCTCCAGT CCAGACCCCT CCTCTGAGCT CCAGACCCTG CTGGACCCAA CCAGCCCTAT GGGGTCGCAT CCCCACCTGC CTGGAATTCT CCAAAGAACC TCCCCTAA CAGTCCAGC CTTTAACAGT TCCAGTCTAA ACACATGACC TTTCTCCTCT AAATCAGCCC CCCATCTCTG CCTTGCAGG AGATGGAAGC CATGACACCT GCCTCGCCCC TGTCCTCACC CCATCCATGT CCAATCAAGC ACTAGGCATG TCAGGT1AC CCTCTAAACT CCTCTGGAAT CCAGTCTCTC AGTCTCCATC ATCCCAGGTC GAAGCTAATG GGCTAACTGG TCCTTGCTTC CACTCTACCC CCACTGCAGT CCTGACTTCC TGAGCAGCAG CCAGGGCCTA ATCGATATTC ACACCAAGCG CCAACCTGAC TGAGATATCC TCCTGCACCA TCATCCCTCC ACCCTGTTTA GTTCTGCTCA CCCTCAGTGT TCTCATCAAT AATCCACTCC CCTCACAGGC GCGTITGGGA CCCCATG7TC TATGCTCTCA CAGGACCT TGCITGATTT TTCACTGTAC TTAGGTCAGT TrGCAGTTAT TAAGTGACTG AGCAATGTCT GGCTTCTCCA GTAGACTGTC AGCTCCTAGC CATTGTATAC CTAGCACCGC TGTGTGGGAG CACGTGACAA ACGTCCAGTG AGTCAGGGAC TCAGCAGTCT CCATTTCTCC GCCCTGCTGG AGAATGCGTG TATTTGGCAA TCCCCAGCCC CTGTGCCATC TAACCATCTT TTCTTCTCTG TTCAGCCCAG GTGTGGCCTC ACTCACATCC CACTCTGAGT CCAAATGTTC TCTCCCTGGA AGATATCAAT GTTTCTGTCT GTTCGTGAGG ACTCCGTGCC CACCACGGCC TCTTCAGGT GAGTCAAAGG GA'TTCCTCAG TTCACTAGTT AGGGGAGGTG GGCAGACACC CTGGAGAACT CCCTGGAAAG CTCAACTCTC ATGCCCCGGA CAACAGTTGA AGGAACCATG GTGATGTTAA GCCCAAAGAC AAAACCTCTC AGGTGTCCAA GTCCCTGTTG GAATCTTGGG AGCAGAGGGA ATGTTCTGTG GTCTAGAGGA AGAGGGGCTC AGGGAGGAGA AGGGCACATT CCTGGTTGTT ATATGTTTCT ATCTATCCCA GATGAACTTG GAAGTGAAGG GAAGAGAGTT AAACATTAAA GTAAATACCC AGTGGATCAG ACAGCAATGT GCCAGATTGC CTTGGAAACA AAATATCTCC AACACATGGC TGACATTTGG TGGGAGATCA GAACACCCTA AAGAGAGAAT TTAAGGGGAG GGGGAGGAGG ACCTGAGCCA GAGTAGAAGC AGAGGATAGG GAGATCTGTT CTTGGGGACA GCATGCAA GAAACAAGGC TGAGGGGTCC ACTCCAACCT CTCCACCCTG CTGCAGGTGC TGCCTATGAT GAAGATGAGC AGATGGCCAT CTCAGCTGGG GCCACAGTGC ACTGGACCTA TAGTTTCCAA TTCCGCACTC AGCAGGCATC TTCTGATGA TCCGATGGCT TCTCAGAGCC AGGGATGGGC CAGGATCCAT CCCCTTGGCT ACTGTCTTGC TGAGAAATTT ATAAGCAGCA TCTGGTGCTA TACTTTGGTC TCTAGTGAGT TAGCTCATGA AAGATGATAG ACTCTCCAAG CCAGGGGTAT GCAGGAAATG GGT=TTCTGT AGCTACAGAA ATGGGGTTGA GGGTTGGACC AAGGGACTAC CCAGGGGAAG TCTTACCTTC AGAGGACTCT GGAAAGGAGG CTGCAAGTTT TCATGGGTCA AGAATTCAGA GCCCAGTAGA GACAGCTTAT CTCTGTrCCA AGATGTCTGG GGCCTGGTT GGAAGATTCA AAGGCTAGGA AACCAGGAGC CACCAAAAGC GTAACTGGGG CCAGAGGATC CACTTTCAAG GTGGCAAGTT GGTTCCCCCC ATGTGGCTGC TTGAGTATCC TCACATGGCG GCTCACATCC TTCCAAGTAA GCAATGCAAA AGGCCAAGAA AGATGCTGCA AAGATGTTAT GACCTAGCCT CAGAAATCAC ACACCATCCC TGCCACCATT AGTAAGAAGT CCAGCCCACG TCCAGGAGAA GAGGAAGCAG ATTCCTCCTT TrGAAATGAA GAATATCAAG TAATTCGGGG GGCATATGAA AGCCACCACA CACCACAGGG ATC7ITi-AG AGCATACTTC TTATACCATC ACTGTAGTTC CTTAAGACTC AGGGGCAAAG CCTCACTTCC TTAGCACCCA GTGAAGACCA CGCTTACTCC CTCACTCAAC CCTGCTAC TTCCCACCTC TCCTGTCCAA CATCTAGTGT CACTTCCAG AACATACCAA CAGCTTCCCC AGTTCTGTGC CTCTGCTCAG GCTGTTCCCC CTGCCTGGTC CACTTGTCCT CCTTCTTGTC CGGTCAAAAT GCTTTATC CTTCAAGACC CAGCTCTAGA GTCACCTCCA ACCCC=TACC CACCAGCCCC CTCTCCAAGT CTGTGTCCCA CAACCCCCCT GCTCCCTCCA GGGCACCCTC CACCCTCTGG GCCACAGTTG TCAGGAGTCA GGCAGGGCAG GGGCCGGGTG GTGTCTTCTT TGTGTTCTTG CACTCAGGGC AGAGCTCAGC ACAGAGCAGA CGCTCAAAAA ACA'TfTAAAG GATAGAAGCA TTGATTTGTG GGTCCCCCAG TCTGGCTCCA GGATGCCAGC CAGCTGCTCC TAGAAGCAAA CGGACTiTlC CTGGGAAATC CCAGAGGTGA TGATCAGTAA TCTCTCCCGT GACTCGTAGT TCAGCTCTTC CTCCATGAGC CTGACTATCA GTGGACCTTC CAGAAAGAGC CCCTTCCT TCTCTCACCC ACAGCACAGG GCACTGGGAA AATGCCCAAT GAGTCCTGCC TCTGGGTTGT GCTTTGGACT TTCAGTGTG WO 00/09525 PCTIUS99/1 7712 EPI-109 237 TCTCGCATCC ACTMTCAAC TrGAATGTrG CAACAGCCAT GAAAAAAGAA ATGCAAAGCG ATrCAGGATG AGAbCAATAC CCTACTCCAA AGAAGGCAAC ATAGAAGCTC AGAGAGATCA AGCAATITGC CCAAGACCAC ACAGCTAGGA GTGGAACTCA TGGC TGTCCA AGCCCCATGC CTCTGCTGAA GGTAGAGATG AATI2ACAGCA ACAAGTCTrAG AAAGGTGCCTr GCCCTATGGT CTGTGAGTCT TGCCTAAGAA TGAAAGAGGA GCCAGTGGGT TAAAGATGAG GTCACCAACA ACGGTGGTGT TGG AGTrAC CACTGATAAT AAGGGTGCAA AATGTAAA17 ACTAATG'IM AITrGAGCCTA GTGCAGTGCG TGGGGCA 1T TGCACATTGT CTCTGATCCC TATGACAACC CrGAGAGGTA GTGG=fJAA CTGCCATGfl ACAGGTGAGG TCATrGTGGT TCAAGGACGT TAAGTAACT'r CCCCAGCGTG ACACGGCITA TAAGTAAGGC AGCCAGGATG TGAACCCAGT AGGACTATCr GGCTrGCAAAG TCCCCACCCC CCTCGCCATC TGTATCCTCC AATCACTTCA GTGCITGCT GCATAGAAGG TAACGGAAAT CACGATGCCA CAGACTrGTCC AGGAAGACAG AAACTAGGCA GATGGGCTGG CCATGGTCrC CAAGCCAGAC TGGAATCTCC AGGTCTrGGAA TGATATCATT r rCTr AATAAATI'AA CTCACCCACC ACACGG='~ GAGAGGCTCA AAGTrGACCA ACTCCCT7GG GAGGGCCCCG GTrGATAAGG AAGGAACGTG AATCCTCCCA TCACGGAAGC flrCAAGGAGG TCAAGGGTCC AACAU11GAG A'GTTrAGTG CTGTrGGTGG ATACTrGGCCA AGGAAATATC CCAGTGGAGC CTCGAGATGA AGAACATGAG GCCCCCGn1T AGAACCAAGG ATCAGAGGGG GCTCTGTAAG ACCCAGGGGA GTCAGGTGCA CTGGAGCGCG GGCATGCAGA AAACAGCCTG AGCTCCACCT CGGCTrCTCC 'TrGTCCTGGC TGGT-rGTCCT TAACCCCTGT CTCC'TrCTGG ACCAGTI~ GTCcT]rCCC TGTGACCGCT GAGGGGTAAC AGCCrTrC CACiMrrr CAGCGCCGAC ATGCTCAATG TCACCIGCA AGGGCCCAcT CT7AACGGGA CCMhGCCCA GAGCAAATGC CCCCAAGTGG AGTGGCTGGG CTrGGCTCAAC ACCATCCAGC CCCCCc~r CTGGGTGCTG TrCGTGCTGG CCACCCTrAGA GAACAT='~ GTCCTCAGCG T=TCTGCCT GCACAAGAGC AGCTGCACGG TGGCAGAGAT CTrACCTGGGG AACCTrGGCCG CAGCAGACCT GATCCTGGCC TGCGGGCTGC C=C~TGGGC CATCACCATC TCCAACAACT TCGACTGGCT C'TGGGGAG ACGCTCTGCC GCGTGGTGAA TGCCAT7ATC TCCATGAACC TGTACAGCAG CATCTGM~C CTGATGCTGG TGAGCATCGA CCGCTACCTG GCCCTGGTGA AAACCATGTC CATGGGCCGG ATGCGCGGCG TGCGC TGGGC CAAGCTCrAC AGCT-rGGTGA TCTGGGGGTG TACGCTGCTC CTGAGCTrCAC CCATGC FGGT GT7CCGGACC ATGAAGGAGT ACAGCGATGA GGGCCACAAC GTCACCG=r GTGTCATCAG CTACCCATCC CTCATcTGGG AAGTGTrCAC CAACATGCTC CTrGAATGTCG TGGGCTrCCT GCTFGCCCCTG AGTGTCATCA CCTTcTrGCAC GATGCAGATC ATGCAGGTGC TGCGGAACAA CGAGATGCAG AAGTTCAAGG AGATCCAGAC GGAGAGGAGG GCCACGGTGC TAGTCCTGGT TGTGCTrGCTG CTATT1CATCA TCTGCTGGCT GCC=TCCAG ATCAGCACCT TCCTGGATAC GCTrGCATCGC CTCGGCATCC TCTrCCAGC TG CCAGGACGAG CGCATCATCG ATGTAATCAC ACAGATCGCC TCC1TCATGG CCTACAGCAA CAGCTGCCTC AACCCACTGG TGTACGTGAT CGTGGGCAAG CGC'ITCCGAA. AGAAGTCTI7G GGAGGTGTAC CAGGGAGTGT GCCAGAAAGG GGGC TGCAGG TCAGAACCCA 7rCAGATGGA GAACTCCATG GGCACACTGC GGACCTCCAT CTCCGTGGAA CGCCAGATTC ACAAACTrGCA GGACTGGGCA GGGAGCAGAC AGTGAGCAAA CGCCAGCAGG GCTGCIrGTGA ATIT7GTGTAA GGATTGAGGG ACAG'rGCrT TFCAGCATGG GCCCAGGAAT GCCAAGGAGA CATCTATGCA CGACCTTGGG AAATGAGTTG ATGTCTrCCGG TAAAACACCG GAGACTrAAT7 CCTGCCCTrGC CCAATI=GC AGGGAGCATG GCTGTGAGGA TGGGGTGAAC TCACGCACAG CCAAGGAcC CAAAATCACA ACAGCATrAC TG~rCTrATr TGCTGCCACA CCTGAGCCAG CCTGCTCCTTr CCCAGGAGTG GAGGAGGCCT GGGGGCAGGG AGAGGAGTGA CTGAGCTTCC C TCCCGTGTG 'ITCTCCGTCC CTrGCCCCAGC AAGACAACTr AGATCIrCCAG GAGAACTGCC ATCCAGCMI GGTGCAATGG CTGAGTGCAC AAGTGAGTrG TTGCCCGGG M=C'~AAT ClA1rCAGC1r AGAACMTGA AGGACAAMT =TGCATTAA TAAAGGTrAA GCCC TGAGGG GTCCVITGATA ACAACCTrGGA GACCAGGATr TTATGGCTCC CCTCACTrGAT GGACAAGGAG GTCTGTGCCA AAGAAGAATC CAATAAGCAC ATATTGAGCA CT7GCTrGTAT ATGCAGTA117 GAGCACTGTA GGCAAGAGGG AAGAAAGAGA AGGAGCCATC TCCATCflGA AGGAACTCAA AGACITCAAGT GGGAACGACT GGGCACTrGCC ACCACCAGAA AGCrGTrCGA TGAGACGGTC GAGCAGGGTG CTGTGGGTGA TATGGACAGC AGAAGGGGGA GCCAGGTTCC AGCTCACCAA TACTrAT-rGCA CACCACCTGT CCTGCCUrC -3' (FRAG. NO:2275) (SEQ. ID NO:2454) 5'- CAGATrCACA AACTGCAc3GA CTGGGCAGGG AGCAGACAGT GAGCAAACGC CAGCAGGGCT GCTGTGAAT'T TGTGTAAGGA TTGAGGGACA GTTGCT=C AGCATGGGCC CAGGAATGCC AAGGAGACAT CTATGCACGA CCTI'GGGAAA TGAG ITGATG TCTCCGGTAA AACACCGGAG ACTAATrCCT GCCCTGCCCA AT1TGCAGG GAGCATGGCT GTGAGGATGG GGTGAACTCA CGCACAGCCA AGGACTCCAA AATCACAACA GCATlACTGT TCT]7AMIGC TGCCACACCT GAGCCAGCCT GCTCC'FrCCC AGGAGTGGAG GAGGCCTGGG GGGAGGGAGA GGAGTGACTG AG=TCCCTC CCGTGTGT~rC TCCGTCCCTG CCCCAGCAAG ACAACTAGA TCTCCAGGAG AACTGCCATC CAGC1TGGT GCAATGGCTG AGTGCACAAG TGAG'rGTrG CCCTrGGGTI CTAATCTA TTCAGCTAGA AC'=GAAGG ACAA'rrCyr GCATTAATAA AGGYTAAGCC C TGAGGGGTC CCTGATAACA ACC TGGAGAC CAGGATITA TGGCTCCCCT CACTGATGGA CAAGGAGGTC TGTGCCAAAG AAGAATCCAA TAAGCACATA TTGAGCACTT GCTGTATATG CAGTATrGAG CACTGTAGGC AAGACCCAAG AAAGAGAAGG AGCCATCTCC ATCTGAAGG AACTCAAAGA CTCAAGTGGG AACGACI'GGG CACTGCCACC ACCAGAAAGC TGTTCGACGA GACGGTCGAG CAGGGTGCTrG TGGGTGATAT GGACAGCAGA AGGGGGAGAC CAAGG FrCCA G~rCAACCAA TAACTAT1TGC ACAACCACCT GTCCCTGCCT CAGTrCC= T 'TATGTAACA TGAAGTCGT GTGAGGGTrA AAGGCAGTAA. CAGGTATAAA GTACTrAGAA AAGCAAAGGG TGCrACGTAC ATGTGAGGCA TCA'rrACGCA GACGTAACTG GGATATG'IrT ACTATAAGGA AAAGACACTrG AGGTCTAGAA ATAGC TCCGT GGAGCAGAAT CAGTAUTGGG AGCCGGTGGC GGTGTGAAGC ACCAGTGTCTr GGCACACAGT AGGTGCTCAT TGGCTCCC 17 CCACCTGTCA T7CCCACCAC CCTGAGGCCC CAACCGCCAC ACACACAGGA GCA'ITGGAG AGAAGGCCAT GTCTrCAAAG TCTGAMGT GATGAGGCAG AGGAAGATAT T7CTrAATCGG T=TGCCCAG AGGATCACAG TGCTGAGACC CCCCACCACC AGCCGGTACC TGGGAAGGGG GAGAGTGCAG GCCTGCTCAG GGACTG~rCC TGTC]TCAGCA ACCAAGGGAT TGTTCCTGTC AATCAATGGT 'ITATTGGAAG GTGGCCCAGT ATGAGCCCTA GAAGAGTGTG AAAAGGAATG GCAATGGTGT TCACCATCGG CAGTGCCAGG GCAGCACTCA TTCACTTGAT AAATGAATAT F]TAUAGCTG GTGGAGAGC TAGAACCTGG AGAGCTAGAA CCTrGGAGAAC TAGAACCTGG AGGGCTAGAA CCTGGAGAGG CTAGAACCAA GAAGGGCTAG AACCTGGAGG GGCTAGAACC TAGAGAAGCT AAAACCTGAG CTAGAAGCTG GAGGACTAGA ACCTGGAGGG CTrGGAATCTG AAGGGCTAGA ACCTGGAGGG CTGGAATCTG GAGAGCTAGA ACCTrGGAGGG CTAGAACCTG GAGGGCTrAGA ACCTAGAAGG GCTAGAACCTr GGAGGGC TGG AATCTrGGAGA GCTAGAACCr GGAGGGcrAG AACCTGGAGG GCTAGAACCT AGAAGGGCTA GAACCTGGAG GGCTAGAACC TGGCAGGTrA GAACCTrAGAA GGGCTAGAAC CTGGAGAGCC AGAACC TGGA GGGCTAGAAC CTGGAAGGGC TAGAACC7GT AGAGCrAGAA CATGGAGAGC TAGAACCCGG CAGGCTAGAA CCTGGCAAGC TAGAACCTGG AGGGAATGAA CCTGGAGGGC TAGAACCTGG AGAATGAGAA AAATITACAT GGCAAAGAGC CCATAAATCC TGACCAATCC AACTCrGAAT 'FMAAAGCAA AAGCGTGAAA AAAAAGATTC CCTrCCTTrACC CCCAACCCAC TC'ITI1CC CACCACCCAC TCTCCrCTGC CTCAGTAAGT ATCTGGAGGA AGAAAACAGG TGAAAGAAGA AGTAAAAACC A'1AGTATr AGTArrAGAA TGAAGTCAAA C7GTGCCACA CATGGTGAAT GAAAAAAAAA AAAAAGAGGC TGTGTIGT CACACAGGGC AGTCAITCAG WO 00/09525 PCTIUS99/17712 EPI-109 238 CACCAGAGCA CGTGATGGTC TGAGACTCTC TTAGGAGCAG AGCTCTGCCG CAATGGCCAT GTGGGGATCC ACACCTGGTC TGAGGGGCAA CTGAGTCTGC GGGAGAAGAG CGGCCCTATG CATGGTGTAG ATGCCCTGAT AAAGAACATC TGTCCTGTGA AAGACTCAAT GAGCTGTTAT GTTGTAAACA GGAAGCATTT CACATCCAAA CGAGAAAATC ATGTAAACAT GTGTCITITC TGTAGAGCAT AATAAATGGA TGAGGI71 GCAAAAAAAA AAAAAAAAA -3' (FRAG. NO:2275) (SEQ. ID NO:2453) 5'- GAGCTCTTCA ATATTAGT GAAAGCTATA GATGAGGCTC CATAGGGGAT AAAGCACAGA CACACCITT CAGAGGGCTT GTGGACTCTG GGCAGCCTGT CCATAGACCT CTGTCCCCAA CTGGCAAGTC AGGAAACTCC AGATTAAGGA GCCCCAATGT GGTTGAACAG CCAGGTGCAC AGATGAGTCA ACCACACAGC CAGGCCAGGG AGGGCCTTCA CTCAAGAGCC TACAGCCAGT TCACAGCCAA GCCAGGGCTA GCGCCAGGCC ACCCATAAAC TGATCTGAGA CTCTGTTTCC CTGTCTCCAT GATGATGGGA TCAGGCTTGA TrGCTGGT'I7 GTAGGCTTGT TATGAATCAA GTCACAGGGA AGAGGAGCTG ATGGGCTGGG GGGACGTCCT CTGGCCCTCC TGTCTCTTCC CCAGATCCAC TGGGCCCACT CTTATCTGTT CTCTTCTGAA GGAAGGGTTT TAAGGCTTCA AAAAAAAATG TIGAAAGT CCCTGCCCTT TCCAGCTCCT ACCGTCTCAG CCCTGGGAGT GTAAAGTGCT GCAGATAGTT AGTAAGTCTT TGAGCAAAAC TGAGAAAGCC AGCCTGAGCC TTGACATGGG AGAAACCTCC GCCATACATC TCCGAAGAAA CGGCCGCGTG TCTCAGGGGA GCGCAAACAC CCGTACCCAG GAAACAGGAC AGCTTCTGCC ACTGTCGCCC TTGGGAGCCG TACGTGGCAT GACAAAGAAA TCCCAGGACT CCGCCTGCCC ACCTGGCCAC CCTCTGTTA CACCTTCCGC GTAAACGCCC ACTGITTACA TCCAAAACTC AGACACAAAA TAACCACCTC AAGAAGATAA ATAATGATAA GAAATAAATG TTACGCGAGG CAAATITATT CACATGGGGC 7TCCCAGGCC ACTGTGGT CAGCCGGGAG GGACGITITT GCCGTCCCAC GACTCCAACG GGCAGCCGGG CCTACGCAAA CATGGAAATC TTCCAAGAGC CTCCCTGGCC CCCAGGGCTC AGAGGGTGGC AGAGCGGAGA GCGAAGGTGG CCGCAGCCTT CCCGGCCCCA CAGCCAGCCT GGCTCCAGCT GGGCAGGAGT GCAGAGCTCA GCTGGAGGCG AGGGGGAAGT GCCCAGGAGG CTGATGACAT CACTACCCAG CCCTTCAAAG ATGAGCTGTr CCCGCCGCCA CTCCAGCTCT GGCTTCTGGG CTCCGAGGAG GGGTGGGGAC GGTGGTGACG GTGGGGACAT CAGGCTGCCC CGCAGTACCA GGGAGCGACT GAAGTGCCCA TGCCGCTrGC TCCGGAGAAG GTGGGTGCCG GGCAGGGGCT GCTCCAGCCG CCTCACCTCT GCTGGGAGGA CAAACTGTCC CAGCACAGAG GGAGGGAGGG AGGGCAGGCA GCGGGGAGAA GTTTCCCTGT GGTCGTGGGG AGTTGGGAAA AGTTCCCTTC CTTCCGGAGG GAGG -3' (FRAG. NO:2275) (SEQ. ID NO:2452) 5'- GCCCTTCAAA GATGAGCTGT TCCCGCCGCC ACTCCAGCTC TGGCTTCTGG GCTCCGAGGA GGGGTGGGGA CGGTGGTGAC GGTGGGGACA TCAGGCTGCC CCGCAGTACC AGGGAGCGAC TGAAGTGCCC ATGCCGCTTG CTCCGGAGAA GGTGGGTGCC GGGCAGGGGC TGCTCCAGCC GCCTCACCTC TGCTGGGAGG ACAAACTGTC CCAGCACAGA GGGAGGGAGG GAGGGCAGGC AGCGGGGAGA AGTITCCCTG TGGTCGTGGG GAGTT -3' (FRAG. NO:2275) (SEQ. ID NO:2451) 5'- GCCCTTCAAA GATGAGCTGT TCCCGCCGCC ACTCCAGCTC TGGCTTCTGG GCTCCGAGGA GGGGTGGGGA CGGTGGGGAC ATCAGGCTGC CCCGCAGTAC CAGGGAGCGA CTGAAGTGCC CATGCCGCTT GCTCCGGAGA AGGTGGGTGC CGGGCAGGGG CTGCTCCAGC CGCCTCACCT CTGCTGGGAG GACAAACTGT CCCAGCACAG AGGGAGGGAG GGAGGGCAGG CAGCGGGGAG AAGTTTCCCT GTGGTCGTGG GGAGTT -3' FRAGG. NO:2275) (SEQ. ID NO:2450) 5'- ATGTTCTCTC CCTGGAAGAT ATCAATGTTT CTGTCTGTTC GTGAGGACTC CGTGCCCACC ACGGCCTCTT TCAGCGCCGA CATGCTCAAT GTCACCTTGC AAGGGCCCAC TCTITAACGGG ACCTGCCC AGAGCAAATG CCCCCAAGTG GAGTGGCTGG GCTGGCTCAA CACCATCCAG CCCCCCTTCC TCTGGGTGCT GTTCGTGCTG GCCACCCTAG AGAACATCTT TGTCCTCAGC GTCTTCTGCC TGCACAAGAG CAGCTGCACG GTGGCAGAGA TCTACCTGGG GAACCTGGCC GCAGCAGACC TGATCCTGGC CTGCGGGCTG CCCTTCTGGG CCATCACCAT CTCCAACAAC TTCGACTGGC TCTITGGGGA GACGCTCTGC CGCGTGGTGA ATGCCATTAT CTCCATGAAC CTGTACAGCA GCATCTGTTT CCTGATGCTG GTGAGCATCG ACCGCTACCT GGCCCTGGTG AAAACCATGT CCATGGGCCG GATGCGCGGC GTGCGCTGGG CCAAGCTCTA CAGCTTGGTG ATCTGGGGGT GTACGCTGCT CCTGAGCTCA CCCATGCTGG TGTTCCGGAC CATGAAGGAG TACAGCGATG AGGGCCACAA CGTCACCGCT TGTGTCATCA GCTACCCATC CCTCATCTGG GAAGTGTrCA CCAACATGCT CCTGAATGTC GTGGGCTTCC TGCTGCCCCT GAGTGTCATC ACCTTCTGCA CGATGCAGAT CATGCAGGTG CTGCGGAACA ACGAGATGCA GAAGTTCAAG GAGATCCAGA CGGAGAGGAG GGCCACGGTG CTAGTCCTGG TTGTGCTGCT GCTATTCATC ATCTGCTGGC TGCCCTTCCA GATCAGCACC TTCCTGGATA CGCTGCATCG CCTCGGCATC CTCTCCAGCT GCCAGGACGA GCGCATCATC GATGTAATCA CACAGATCGC CTCCTTCATG GCCTACAGCA ACAGCTGCCT CAACCCACTG GTGTACGTGA TCGTGGGCAA GCGCTTCCGA AAGAAGTCTT GGGAGGTGTA CCAGGGAGTG TGCCAGAAAG GGGGCTGCAG GTCAGAACCC ATTCAGATGG AGAACTCCAT GGGCACACTG CGGACCTCCA TCTCCGTGGA ACGCCAGATT CACAAACTGC AGGACTGGGC AGGGAGCAGA CAGTGAGCAA ACGCCAGCAG GGCTGCTGTG AATTTGTGTA AGGATTGAGG GACAGTTGCT T -3' (FRAG. NO:2275) (SEQ. ID NO:2449) 5'- ATGTTCTCTC CCTGGAAGAT ATCAATG1TTT CTGTCTGTT GTGAGGACTC CGTGCCCACC ACGGCCTCTT TCAGCGCCGA CATGCTCAAT GTCACCTTGC AAGGGCCCAC TCTTAACGGG ACCTTGCCC AGAGCAAATG CCCCCAAGTG GAGTGGCTGG GCTGGCTCAA CACCATCCAG CCCCCCTTCC TCTGGGTGCT GTTCGTGCTG GCCACCCTAG AGAACATCIT TGTCCTCAGC GTCTTCTGCC TGCACAAGAG CAGCTGCACG GTGGCAGAGA TCTACCTGGG GAACCTGGCC GCAGCAGACC TGATCCTGGC CTGCGGGCTG CCCTTCTGGG CCATCACCAT CTCCAACAAC TTCGACTGGC TCTTGGGGA GACGCTCTGC CGCGTGGTGA ATGCCATTAT CTCCATGAAC CTGTACAGCA GCATCTGTTr CCTGATGCTG GTGAGCATCG ACCGCTACCT GGCCCTGGTG AAAACCATGT CCATGGGCCG GATGCGCGGC GTGCGCTGGG CCAAGCTCTA CAGCTTGGTG ATCTGGGGGT GTACGCTGCT CCTGAGCTCA CCCATGCTGG TGTTCCGGAC CATGAAGGAG TACAGCGATG AGGGCCACAA CGTCACCGCT TGTGTCATCA GCTACCCATC CCTCATCTGG GAAGTGTTCA CCAACATGCT CCTGAATGTC GTGGGCTTCC TGCTGCCCCT GAGTGTCATC ACCTTCTGCA CGATGCAGAT CATGCAGGTG CTGCGGAACA ACGAGATGCA GAAGTfCAAG GAGATCCAGA CGGAGAGGAG GGCCACGGTG CTAGTCCTGG TTGTGCTGCT GCTATTCATC ATCTGCTGGC TGCCCTTCCA GATCAGCACC TTCCTGGATA CGCTGCATCG CCTCGGCATC CTCTCCAGCT GCCAGGACGA GCGCATCATC GATGTAATCA CACAGATCGC CTCCTTCATG GCCTACAGCA ACAGCTGCCT CAACCCACTG GTGTACGTGA TCGTGGGCAA GCGCTTCCGA AAGAAGTCT GGGAGGTGTA CCAGGGAGTG TGCCAGAAAG GGGGCTGCAG GTCAGAACCC ATTCAGATGG AGAACTCCAT GGGCACACTG CGGACCTCCA TCTCCGTGGA ACGCCAGATT CACAAACTGC AGGACTGGGC AGGGAGCAGA CAGTGAGCAA ACGCCAGCAG GGCTGCTGTG AA'TGTGTA AGGATTGAGG GACAGTTrGCT T -3' (FRAG. NO:2275)(SEQ. ID NO:2448) 5'- TGATCCTATC ACAACCTGAG AGTAGITITT ACTCCATITA CAGGTGAGGT CATTGTGGTT CAAGGACGTT AAGTAACTTC CCCAGCTCAC ACGGCTTATA AGTAAGGCAG CCAGGATGTG AACCCAGTAG GACTATCTGG CTGCAAAGTC CCCACCCTCC CTCGCCATCT GTATCCTCCA ATCATCTrCA GTGCITTGCT GATAGAAGGT ACGGAAATAC GATGCCACAG ACTGTCCAGG AAGACAGAAA CTAGGCAGAT GGGCTGGCCA TGGTCTCCAA GCCAGACTGG AATCTCCAGG TCTGGAATGA TATCAITIT CTCrI rAAT AAATTAACTC ACCCACCACA CGGCTTGAG AGGCTCAAAG GTGACCAACT CCCrTGGGAG GGCCCCGGTT GATAAGGAAG GAATGTGAAT CCTCCCATCA CGGAAGCTTC AAGGAGGTCA AGGGTCCAAC ACTTGAGATT GTTAGTGCTG WO 00/09525 PCT/US99/17712 EPI-109 239 TTGGTGGATA CTGCAGAATA TCCAGTGGAG CCTCAGATGA AGAACATGAG GCCCCGTTTA GATCCAAGGA TCAGAGGGGG CTCTGTAAGA CCCAGGGGAG TCAGGTGCAC TGGAGCGCGG GCTGCAGAAA ACAGCCTGAG CTCCACCTCG GCTCTCCTT GCCCTGGCTG GTTGTCCTTA ACCCCTGTCT CCTTCTGGAC CAG1T111GT CCTTCCCTTG TGACCTGAGG GGTAACAGCC TCTITTCCAC TTTCTTTCAG CGCCGACATG CTCAATGTCA CCTTGCAAGG GCCCACTCTT AACGGGACCT TTGCCCAGAG CAAATGCCCC CAAGTGGAGT GGCTGGGCTG GCTCAACACC ATCCAGCCCC CCTTCCTCTG GGTGCTGTTC GTGCTGGCCA CCCTAGAGAA CATCTGTC CTCAGCGTCT TCTGCCTGCA CAAGAGCAGC TGCACGGTGG CAGAGATCTA CCTGGGGAAC CTGGCCGCAG CAGACCTGAT CCTGGCCTGC GGGCTGCCCT TCTGGGCCAT CACCATCTCC AACAACTTCG ACTGGCTCTT TGGGGAGACG CTCTGCCGCG TGGTGAATGC CATTATCTCC ATGAACCTGT ACAGCAGCAT CTGTTTCCTG ATGCTGGTGA GCATCGACCG CTACCrGGCC CTGGTGAAAA CCATGTCCAT GGGCCGGATG CGCGGCGTGC GCTGGGCCAA GCTCTACAGC TTGGTGATCT GGGGGTGTAC GCTGCTCCTG AGCTCACCCA TGCTGGTGTT CCGGACCATG AAGGAGTACA GCGATGAGGG CCACAACGTC ACCGCTTGTG TCATCAGCTA CCCATCCCTC ATCTGGGAAG TGTTCACCAA CATGCTCCTG AATGTCGTGG GCTTCCTGCT GCCCCTGAGT GTCATCACCT TCTGCACGAT GCAGATCATG CAGGTGCTGC GGAACAACGA GATGCAGAAG TTCAAGGAGA TCCAGACGGA GAGGAGGGCC ACGGTGCTAG TCCTGGTTGT GCTGCTGCTA TTCATCATCT GCTGGCTGCC CTTCCAGATC AGCACC=TCC TGGATACGCT GCATCGCCTC GGCATCCTCT CCAGCTGCCA GGACGAGCGC ATCATCGATG TAATCACACA GATCGCCTCC TTCATGGCCT ACAGCAACAG CTGCCTCAAC CCACTGGTGT ACGTGATCGT GGGCAAGCGC TTCCGAAAGA AGTCTrGGGA GGTGTACCAG GGAGTGTGCC AGAAAGGGGG CTGCAGGTCA GAACCCATTC AGATGGAGAA CTCCATGGGC ACACTGCGGA CCTCCATCTC CGTGGAACGC CAGATTCACA AACTGCAGGA CTGGGCAGGG AGCAGACAGT GAGCAAACGC CAGCAGGGCT GCTGTGAATT TGTGTAAGGA TTGAGGGACA GTTGCTFI1IC AGCATGGGCC CAGGAATGCC AAGGAGACAT CTATGCACGA CCTTGGGAAA TGAGTGTTGA TGTCTCCGGT AAAACACCGG AGACTAATTC CTGCCCTGCC CAATTTTCGA GGGAGCATGG CTGTGAGGAT GGGGTGAACT CACGCACAGC CAAGGACTCC AAAATCACAA CAGCATTACT GTTCTrAT GCTGCCACAC CTGAGCCAGC CTGCTCCTTC CCAGGAGTGG AGGAGGCCTG GGGGAGGGAG AGGAGTGACT GAGCTTCCCT CCCGTGTGTT CTCCGTCCCT GCCCCAGCAA GACAACTTAG ATCTCCAGGA GAACTGCCAT CCACGTTTGG TGCAATGGCT GAGTGCACAA GTGAGTTGTT GCCCTGGGTT TCTTTAATC7 ATCAGCTAGA ACITTGAAGG ACAATTTCTT GCATTAATAA AGGTTAAGCC CTGAGGGGTC CCTTGATAAC AACCTGGAGA CCAGGATTTT ATGGCTCCCC TCACTGATGG ACAAGGAGGT CTGTGCCAAA GAAGAATCAA TAAGCACATA TGAGCACTTC TGTATATCAG TATTGAGCAC TGTAGGCA -3' (FRAG. NO:2275) (SEQ. ID NO:2447) 5'- CTGCAGAAAA CAGCCTGAGC TCCACCTCGG CrTCTCCTTG CCCTGGCTGG TTGTCCTTAA CCCCTGTCTC CTTCTGGACC AGT11T-GTC CTTCCCTTGT GACCCTGAGG GGTAACAGCC TCUT1CCAC TTC1TTTCAG CGCCGACATG CTCAATGTCA CCTTGCAAGG GCCCACTCT AACGGGACCT TrGCCCAGAG CAAATGCCCC CAAGTGGAGT GGCTGGGCTG GCTCAACACC ATCCAGCCCC CCTTCCTCTG GGTGCTGTTC GTGCTGGCCA CCCTAGAGAA CATCITGTC CTCAGCGTCT TCTGCCTGCA CAAGAGCAGC TGCACGGTGG CAGAGATCTA CCTGGGGAAC CTGGCCGCAG CAGACCTGAT CCTGGCCTGC GGGCTGCCCT TCTGGGCCAT CACCATCTCC AACAACTTCG ACTGGCTCTT TGGGGAGACG CTCTGCCGCG TGGTGAATGC CATTATCTCC ATGAACCTGT ACAGCAGCAT CTGTTTCCTG ATGCTGGTGA GCATCGACCG CTACCTGGCC CTGGTGAAAA CCATGTCCAT GGGCCGGATG CGCGGCGTGC GCTGGGCCAA GCTCTACAGC TTGGTGATCT GGGGGTGTAC GCTGCTCCTG AGCTCACCCA TGCTGGTGTT CCGGACCATG AAGGAGTACA GCGATGAGGG CCACAACGTC ACCGCTTGTG TCATCAGCTA CCCATCCCTC ATCTGGGAAG TGTrCACCAA CATGCTCCTG AATGTCGTGG GCTTCCTGCT GCCCCTGAGT GTCATCACCT TCTGCACGAT GCAGATCATG CAGGTGCTGC GGAACAACGA GATGCAGAAG TTCAAGGAGA TCCAGACGGA GAGGAGGGCC ACGGTGCTAG TCCTGGTTGT GCTGCTGCTA TTCATCATCT GCTGGCTGCC CTTCCAGATC AGCACCTTCC TGGATACGCT GCATCGCCTC GGCATCCTCT CCAGCTGCCA GGACGAGCGC ATCATCGATG TAATCACACA GATCGCCTCC TTCATGGCCT ACAGCAACAG CTGCCTCAAC CCACTGGTGT ACGTGATCGT GGGCAAGCGC TTCCGAAAGA AGTCTTGGGA GGTGTACCAG GGAGTGTGCC AGAAAGGGGG CTGCAGGTCA GAACCCATTC AGATGGAGAA CTCCATGGGC ACACTGCGGA CCTCCATCTC CGTGGAACGC CAGATTCACA AACTGCAGGA CTGGGCAGGG AGCAGACAGT GAGCAAACGC CAGCAGGGCT GCTGTGAATT TGTGTAAGGA TTGAGGGACA GTrGCTITC AGCATGGGCC CAGGAATGCC AAGGAGACAT CTATGCACGA CCTrGGGAAA TGAGTTGATG TCTCCGGTAA AACACCGGAG ACTAA'TTCCT GNCCTGCCCA ATTTTGCAGG GAGCATGGCT GTGAGGATGG GGTGAACTCA CGCACAGCCA AGGACTCCAA AATCACAACA GCATTACTGT TCTTATGC TGCCACACCT GAGCCAGCCT GCTCCTTCCC AGGAGTGGAG GAGGCCTGGG GGCAGGGAGA GGAGTGACTG AGCTTCCCTC CCGTGTGTTC TCCGTCCCTG CCCCAGCAAG ACAACTTAGA TCTCCAGGAG AACTGCCATC CAGCTGGT GCAATGGCTG AGTGCACAAG TGAGTTGTTrG CCCTGGGTTT CTTTAATCTA TTCAGCTAGA ACTTGAAGG ACAA'TTCTT GCATTAATAA AGGTTAAGCC CTGAGGGGTC CCTGATAACA ACCTGGAGAC CAGGATTTTA TGGCTCCCCT CACTGATGGA CAAGGGAGGT CTGTGCCAAA GAAGAATCCA ATAAGCACAT ATTGAGCACT TGCTGTATAT GCAGTATTGA GCACTGTAGG CAAGAGGGAA GAAAGAGAAG GAGCCATCTC CATCTTGAAG GAACTCAAAG ACTCAAGTGG GAACGACTGG CACTGCCACC ACCAGAAAGC TGTTCGACGA GACGGTCGAG CAGGGTGCTG TGGGTGATAT GGACAGCAGA AGGGGGAGAC CAAGGTTCCA GCTCAACCAA TAACTATTGC ACAACCACCT GTCCCTGCCT CAGTTCCCTC TTCTGTAACA TGAAGTCGTT GTGAGGGTTA AAGGCAGTAA CAGGTATAAA GTACTTAGAA AAGCAAAGGG TGCTACGTAC ATGTGAGGCA TCATrACGCA GACGTAACTG GGATATGTTT ACTATAAGGA AAAGACACTG AGGTCTAGA -3' (FRAG. NO:2275) (SEQ. ID NO:2446) 5'- AAATGATAGA CCGTCAATAA TTTGTAAAT GCITI iAAA ATGAATGCTT TAAGCCGGGT GCAGTGCCTC ACATCTGTAA TCCCAGCACT TTGGAGCCGA GCGGGTGGAT TGTGTGAGGT CAGGAGTTCG AGACCAACCT GGCCAACATG GCAAAACCTC ACTCTCTACC AAAAATACAA AAATTAGCCA GGCATGGTGG CAGGCACCTG TGATCCCAGC TACTCAGGAG GCTGAGACAG GAGAATCGCT TGAACCCGGG AGGCAAGGTT GCAGTGAGCC AAGATTACGC CATTfGTACTC CAGCCTGGGT GACAGAGAGA GACTCCGTCT CAAAAAAAAA AAAAAAAAAA AAAAAATTAC GCTrCAAACA CATGATCTCT CACCACTGTr GAATTCTT TCTATGAGCC CAGGAGGGCC TCTCAGAGAG GAAAGCTCCT AGGTCTTCCT TTCCCTCTGC AAACTCCCTG CCTTGAAGGT TCAGAAGGAC TGTGCGTGCT CGTTGCATCC TTTGCAAGTG TCCAAACCCT GATCCCAGCT GTGCTTAGGG GTTCCTGCAA ACCI=TTCCA GGTGTTAATT ACCTCCCACT TCATTCCTG MTTACCAACT CAGCITITG TIllAGTGTG TTGAATTCC CTGAACTGAC CGTTGTCTGA TCTCCACCTC CCAACTGAAT TAGGGGAGCT GGGCTTCTGG AAACCCAGGT GCCGGGTGTT GCAGAGTGGC TGAAAGCTGG GATGTGGCAG ATCCGTGGCT ACATTCATGC ACACACACAC ACCCACATAC CCACACATGC ACACACACAC ACACACCCGC ACTCACACAC TTGGACATGC ATAGACCACA GCTTCCACA CCCTTCCTAG ACAGGGGTCA CTTGGTATCC TGGAGAGAGT GTGAAGTCCT GGAATGGAAA GAGGGGGGAT TAAGCCCCAC CTCTAGCCAT GGGACTGAGA CAAGTCACCA CCAACCCATC TGCGCCTGT TTACCTCCTC TGTGAGGCAA GCACAGAGCC CATGCCTGCC CCCCTGGATG GGAGTGATGT GAAACTTGAA GGGCGGTCAG AGCAAGGGTC GGGAATGGAA GGCCCTTGGG AAAAAAGGCC CTITCAACTA WO 00/09525 PCT/US99/1 77-12 EP[-109 240 GGGGCACAGA GGAGGCCCTG GGCTGAGAAC TrGACAGCAC CT7GTAA F7G GTAAGCCAAG CCCGAAGGGA CTGGAAATAC TCAGATGTGT CTGTCTCCCTr TATTAGGTrC AAAGTCCCTC AAGACCCTGT CTCCATCACA GTGCTCCAGT CCAGACCCCT CCTCTGAGCT CCAGACCCTG CTGGACCCAA CCAGCCCTAT GGGGTCGCAT CCCCACCTrGC CTGGAATrCTr CCAAAGAACC TCCCCFIAA CAGTTCCAGC C=PAACAGT TCCAGTCTAA. ACACATGACC 'IrrCTCCTCT AAATCAGCCC CCCATCTCTG CCI=GCAGG AGATGGAAGC CATGACACCT GCCTCGCCCC TGTCC TCACC CCATCCATGT CCAATCAAGC ACTAGGCATG TCAGGTT7AC CCTrCTAAACTr CCTCTGGAAT CCAGTCTrCTC AGTCTrCCATC ATCCCAGGTC GAAGCTAATG GGCTAACTGG TCCT'rGCT'rC CACTCTACCC CCACTGCAGT CCTGACTTCC TGAGCAGCAG CCAGGGCCTA ATCGATATTC ACACCAAGCG CCAACCTGAC TGAGATATCC TCCTrGCACCA TCATCCCTCC ACCCTGTI7rA G'ITCTGC1TCA CCCTCAGTGT TCTCATCAAT AATCCACTCC CCTCACAGGC GCGTITGGGA CCCCATGTTC TATGCTCXrCA CAGGACCTT TGCrrFGAlrrr TCACTGTAC 77AGGTCAGT T-rGCAGTrAT TAAGTGACTG AGCAATGTCT GGCI7CTCCA GTAGACTGTC AGCTCCTAGC CATTGTATAC CTAGCACCGC TGTGTGGGAG CACGTGACAA ACGTCCAGTG AGTCAGGGAC TCAGCAGTcT CCATr7CTCC GCCCTGCTGG AGAATGCGTG TAMIGGCAA TCCCCAGCCC CTGTGCCATC TAACCATC~r Tr=TCTCTG T'rCAGCCCAG GTGTGGCCTC ACTCACATCC CACTCTGAGT CCAAATGTlC TCTCCCTGGA AGATATCAAT GITr1CTGTCT GTTCGTGAGG ACTCCGTGCC CACCACGGCC TCITCAGGT GAGTCAAAGG GATrCCTCAG TTCACTAGT7 AGGGGAGGTG GGCAGACACC CTGGAGAACTr CCCTGGAAAG CTCAACTCTC ATGCCCCGGA CAACAGTrGA AGGAACCATG GTGATGTTrAA GCCCAAAGAC AAAACCTCTC AGGTGTCCAA GTCCCTG~TrG GAATCTrGGG AGCAGAGGGA ATGTrCTGTG GTCTAGAGGA AGAGGGGCTC AGGGAGGAGA AGGGCACATT CCTGGTrGT7 ATATGT77CT ATCTATCCCA GATGAACTTG GAAGTGAAGG GAAGAGAG T7 AAACATTAAA GTAAATACCC AGTGGATCAG ACAGCAATGT GCCAGATGC CTTGGAAACA AAATATCTCC AACACATGGC TGACATrGG TGGGAGATCA GAACACCCTA AAGAGAGAAT T7AAGGGGAG GGGGAGGAGG ACCTrGAGCCA GAGTAGAAGC AGAGGATAGG GAGATCTGT7 CTGGGGACA GCAT~rGCAA GAAACAAGGC TGAGGGGTCC ACTCCAACCT CTCCACCCTG CTGCAGGTGC TGCCTATGAT GAAGATGAGC AGATGGCCAT CTrCAGCTGGG GCCACAGTGC ACTGGACCTA TAG'ITTCCAA TI7CCGCACTC AGCAGGCATC 7TCrGATGA TCCGATGGCT TCTrCAGAGCC AGGGATGGGC CAGGATCCAT CCCCTTGGCT ACTGTCTGC TGAGAAA'IM ATAAGCAGCA TCTGGTGCTA TACT=GGTC TCTAGTGAGT TAGCTCATGA AAGATGATAG ACTCTCCAAG CCAGGGGTAT GCAGGAAATG GGTTICTGT AGCTACAGAA ATGGGGTIrGA GGG'rTGGACC AAGGGAcrAC CCAGGGGAAG TCTTACCTrC AGAGGACTCT GGAAAGGAGG CTGCAAGTIT7 TCATGGGTCA AGAATTCAGA GCCCAGTAGA GACAGCTAT CTCTGTrCCA AGATGTCTcIG GGCCTTGGTT GGAAGAT7CA AAGGCTAGGA AACCAGGAGC CACCAAAAGC GTAACTGGGG CCAGAGGATC CACT1TCAAG GTGGCAAGTT GGTTCCCCCC ATGTGGCTGC TI'GAGTATCC TCACATGGCG GCTCACATCC 'FrCCAAGTAA GCAATGCAAA AGGCCAAGAA AGATGCTFGCA AAGATGTrAT GACCTAGCCT CAGAAATCAC ACACCATCCC TGCCACCATT AGTAAGAAGT CCAGCCCACG TCCAGGAGAA GAGGAAGCAG ATTCCTCCT TI'GAAATGAA GAATATCAAG TAATrCGGGG GGCATATGAA AGCCACCACA CACCACAGGG ATCTITAG AGCATACT7C TFATACCATC ACTrGTAGTI7C CTrAAGACTrC AGGGGCAAAG CCTCACTrrCC TrAGCACCCA GTGAAGACCA CGM~ACTCC CTCACrCAAC CTCMGCTAC TTCCCACCTC TCCTGTCCAA CATC TAGTGT CACMTCCAG AACATACCAA CAG=ICCCC AGT]rCTGTGC CTC TGCTCAG GCTGTTCCCC CTGCC~rGGTC CACTTGTCCT CCITC11TGTC CGGTCAAAAT GCTTCTTATC CPCAAGACC CAGCTrCTAGA GTCACCTCCA ACCCCT7ACC CACCAGCCCC CTCTCCAAGT C TGTGTCCCA CAACCCCCCT GCTCCCTCCA GGGCACCCTC CACCC TCTGG GCCACAGTTG TCAGGAGTCA GGCAGGGCAG GGGCCGGGTG GTGTCC TGTGTrCTTG CACTCAGGGC AGAGCTrCAGC ACAGAGCAGA CGCTCAAAAA ACAMTAAAG GATAGAAGCA T7GA1TGTG GGTCCCCCAG TCTGGCTCCA GGATGCCAGC CAGCTGCTCC TAGAAGCAAA CGGACTITC CTGGGAAATC CCAGAGGTGA TGATCAGTAA TCTrCTCCCGT GACTCGTAGT TCAGCTC TFC CTCCATGAGC CTGACTATCA GTGGACC TTC CAGAAAGAGC CCGT=CCTr TCrCTCACCC ACAGCACAGG GCACTGGGAA AATGCCCAAT GAGTCCTGCC TCTGGGflTGT G='~GGACT 'IMCAGTGTG TCTCGCATCC ACTC17CAAC TrGAATGT7G CAACAGCCAT GAAAAAAGAA ATGCAAAGCG ATrCAGGATG AGAGCAATAC CCTACTCCAA AGAAGGCAAC ATAGAAGCTC AGAGAGATCA AGCAA'IMGC CCAAGACCAC ACAGCTAGGA GTGGAACTCA TGGCTGTCCA AGCCCCATGC CTCTGCTGAA GGTAGAGATG AATTACAGCA ACAAGTCTAG AAAGGTGCCT GCCCTATGGT CTGTGAGTCTr TGCCTAAGAA TGAAAGAGGA GCCAGTGGGT TAAAGATGAG GTCACCAACA ACGGTGGTGT TGiGAG1TITAC CACTrGATAAT AAGGGTGCAA AATGTAAAT ACTAATGMf ATrGAGCCTA GTG3CAGTGCG TGGGGCATI TGCACAT7GT CTCTrGATCCC TATGACAACC CTGAGAGGTA GTGGTITAA CTGCCATGT7 ACAGGTGAGG TCATTGTGGT TCAAGGACGT TAAGTAACIT CCCCAGCGTG ACACGGCTrA TAAGTAAGGC AGCCAGGATG TGAACCCAGT AGGACTATCT GGCTGCAAAG TCCCCACCCC CCUrCGCCATC TGTATCCTCC AATCAC'ITCA GTGCF=GCT GCATAGAAGG TAACGGAAAT CACGATGCCA CAGACTGTCC AGGAAGACAG AAACTAGGCA GATGGGCTGG CCATGGTCTrC CAAGCCAGAC TGGAATCTCC AGGTCTGGAA TGATATCATr TCTCTIT AATAAAYFAA CTCACCCACC ACACGGCMT GAGAGGCTCA AAGTrGACCA ACTCC=rGG GAGGGCCCCG G1TGATAAGG AAGGAACGTG AATCCTCCCA TCACGGAAGC TTCAAGGAGG TCAAGGGTCC AACACT~rGAG AT7GTTAGTG CrGTrGGTGG ATACTrGGCCA AGGAAATATC CCAGTGGAGC CTrCGAGATGA AGAACATGAG GCCCCCGMT AGAACCAAGG ATCAGAGG3GG GCTCTrGTAAG ACCCAGGGGA GTCAGGTGCA CTGGAGCGCG GGCATGCAGA AAACAGCCTG AGCTCCACCT CGG=TCTCC T7GTCCTGGC TGGTrGTCCT TAACCCCTrGT CTCCITCTGG ACCAGTIf= GTC=CrCCT TGTGACCGCTr GAGGGGTAAC AGCCTC ITC CACM=C'~ CAGCGCCGAC ATGCTCAATG TCACCTGCA AGGGCCCACT C17'AACGGGA CC1TGCCCA GAGCAAATGC CCCCAAGTGG AGTGGCTGGG CTGGCTCAAC ACCATCCAGC CCCCCTrCCT CTGGGTGCTG TI7CGTGC TGG CCACCCTAGA GAACATC'= GTCCTCAGCG TCTrCTGCCT GCACAAGAGC AGCTGCACGG TGGCAGAGAT CTACCTGGGG AACC TGGCCG CAGCAGACCT GATCCTGGCC TGCGGGCTrGC CCTTCTGGGC CATCACCATC TCCAACAACr TCGACTGGCT C1TGGGGAG ACGCTCTGCC GCGTGGTGAA TGCCATrATC TCCATGAACC TGTACAGCAG CATCTGTIC CTGATGCTGG TGAGCATCGA CCGCTACCTG GCCCTrGGTGA AAACCATGTC CATGGGCCGG ATGCGCGGCG TGCGCTGGGC CAAGCTCTAC AGCTGGTGA TCTGGGGGTG TACGCTGCTC CTGAGCTCAC CCATGCTGGT GTTCCGGACC ATGAAGGAGT ACAGCGATGA GGGCCACAAC GTCACCGCT GTGTCATCAG CTACCCATCC CTCATCTGGG AAGTG~rCAC CAACATGCTC CTGAATGTCG TGGG=TCCT GCTGCCCCTG AGTGTCATCA CCIT7CTGCAC GATGCAGATC ATGCAGGTGC TGCGGAACAA CGAGATGCAG AAG'FI7CAAGG AGATCCAGAC GGAGAGGAGG GCCACGGTGC TAGTCCTGGT TGTGCTGCTG GTAUrCATCA TCTGCTGGCT GCC=fCCAG ATCAGCACCT TCCTGGATAC GCTGCATCGC CTCGGCATCC TCTCCAGCTG CCAGGACGAG CGCATCATCG ATGTAATCAC ACAGATCGCC TCC TrCATGG CCTACAGCAA CAGCTrGCCTC AACCCACTGG TGTACGTGAT CGTGGGCAAG CGCTICCGAA. AGAAGTCT7G GGAGGTGTAC CAGGGAGTGT GCCAGAAAGG GGGCTGCAGG TCAGAACCCA 'TCAGATGGA GAACTCCATG GGCACACTGC GGACCTCCAT CTCCGTGGAA CGCCAGAT7C ACAAACTGCA GGACTGGGCA GGGAGCAGAC AGTGAGCAAA CGCCAGCAGG GCTGCTrGTGA ATI'GTGTAA GGATrGAGGG ACAGTlGCTI' 'FrCAGCA.TGG GCCCAGGAAT GCCAAGGAGA CATCTATGCA CGACCTTGGG AAATGAGTrG ATGTCTCCGG TAAAACACCG WO 00/09525 PCTIUS99/17712 EPI-109 241 GAGACTAATT CCTGCCCTGC CCAA1T1GC AGGGAGCATG GCTGTGAGGA TGGGGTGAAC TCACGCACAG CCAAGGACTC CAAAATCACA ACAGCATTAC TGTTCTTATT TGCTGCCACA CCTGAGCCAG CCTGCTCCTT CCCAGGAGTG GAGGAGGCCT GGGGGCAGGG AGAGGAGTGA CTGAGCTTCC CTCCCGTGTG TTCTCCGTCC CTGCCCCAGC AAGACAACTT AGATCTCCAG GAGAACTGCC ATCCAGCT GGTGCAATGG CTGAGTGCAC AAGTGAGTTG TTGCCCTGGG TTTCTTTAAT CTATTCAGCT AGAACTTGA AGGACAAIT CTTGCATrAA TAAAGGTTAA GCCCTGAGGG GTCCCTGATA ACAACCTGGA GACCAGGATT TTATGGCTCC CCTCACTGAT GGACAAGGAG GTCTGTGCCA AAGAAGAATC CAATAAGCAC ATATrGAGCA CTTGCTGTAT ATGCAGTATT GAGCACTGTA GGCAAGAGGG AAGAAAGAGA AGGAGCCATC TCCATCTTGA AGGAACTCAA AGACTCAAGT GGGAACGACT GGGCACTGCC ACCACCAGAA AGCTGTTCGA TGAGACGGTC GAGCAGGGTG CTGTGGGTGA TATGGACAGC AGAAGGGGGA GCCAGGTTCC AGCTCACCAA TACTATrGCA CACCACCTGT CCTGCCTC -3' (FRAG. NO:2275) (SEQ. ID NO:2445) 5'- CAGATTCACA AACTGCAGGA CTGGGCAGGG AGCAGACAGT GAGCAAACGC CAGCAGGGCT GCTGTGAATT TGTGTAAGGA TTGAGGGACA GTTGC1T1 C AGCATGGGCC CAGGAATGCC AAGGAGACAT CTATGCACGA CCTTGGGAAA TGAGTTGATG TCTCCGGTAA AACACCGGAG ACTAATTCCT GCCCTGCCCA ATTTGCAGG GAGCATGGCT GTGAGGATGG GGTGAACTCA CGCACAGCCA AGGACTCCAA AATCACAACA GCATTACTGT TCTTATGC TGCCACACCT GAGCCAGCCT GCTCCTTCCC AGGAGTGGAG GAGGCCTGGG GGGAGGGAGA GGAGTGACTG AGCTTCCCTC CCGTGTGTTC TCCGTCCCTG CCCCAGCAAG ACAACTTAGA TCTCCAGGAG AACTGCCATC CAGC1TGGT GCAATGGCTG AGTGCACAAG TGAGTTGTTG CCCTGGGTTT CTTAATCTA TTCAGCTAGA ACTTTGAAGG ACAATTCTT GCATrAATAA AGGTTAAGCC CTGAGGGGTC CCTGATAACA ACCTGGAGAC CAGGATTIA TGGCTCCCCT CACTGATGGA CAAGGAGGTC TGTGCCAAAG AAGAATCCAA TAAGCACATA TTGAGCACTr GCTGTATATG CAGTATTGAG CACTGTAGGC AAGACCCAAG AAAGAGAAGG AGCCATCTCC ATCTTGAAGG AACTCAAAGA CTCAAGTGGG AACGACTGGG CACTGCCACC ACCAGAAAGC TGTTCGACGA GACGGTCGAG CAGGGTGCTG TGGGTGATAT GGACAGCAGA AGGGGGAGAC CAAGGTTCCA GCTCAACCAA TAACTATTGC ACAACCACCT GTCCCTGCCT CAGTTCCCTT TTATGTAACA TGAAGTCGTF GTGAGGGTTA AAGGCAGTAA CAGGTATAAA GTACTTAGAA AAGCAAAGGG TGCTACGTAC ATGTGAGGCA TCATTACGCA GACGTAACTG GGATATGTTT ACTATAAGGA AAAGACACTG AGGTCTAGAA ATAGCTCCGT GGAGCAGAAT CAGTATTGGG AGCCGGTGGC GGTGTGAAGC ACCAGTGTCT GGCACACAGT AGGTGCTCAT TGGCTCCCTT CCACCTGTCA TTCCCACCAC CCTGAGGCCC CAACCGCCAC ACACACAGGA GCATTTGGAG AGAAGGCCAT GTCTrCAAAG TCTGAITGT GATGAGGCAG AGGAAGATAT TTCTAATCGG TCT7GCCCAG AGGATCACAG TGCTGAGACC CCCCACCACC AGCCGGTACC TGGGAAGGGG GAGAGTGCAG GCCTGCTCAG GGACTGTTCC TGTCTCAGCA ACCAAGGGAT TGTTCCTGTC AATCAATGGT TTATTGGAAG GTGGCCCAGT ATGAGCCCTA GAAGAGTGTG AAAAGGAATG GCAATGGTGT TCACCATCGG CAGTGCCAGG GCAGCACTCA TTCACTTGAT AAATGAATAT TTATTAGCTG GTTGGAGAGC TAGAACCTGG AGAGCTAGAA CCTGGAGAAC TAGAACCTGG AGGGCTAGAA CCTGGAGAGG CTAGAACCAA GAAGGGCTAG AACCTGGAGG GGCTAGAACC TAGAGAAGCT AAAACCTGAG CTAGAAGCTG GAGGACTAGA ACCTGGAGGG CTGGAATCTG AAGGGCTAGA ACCTGGAGGG CTGGAATCTG GAGAGCTAGA ACCTGGAGGG CTAGAACCTG GAGGGCTAGA ACCTAGAAGG GCTAGAACCT GGAGGGCTGG AATCTGGAGA GCTAGAACCT GGAGGGCTAG AACCTGGAGG GCTAGAACCT AGAAGGGCTA GAACCTGGAG GGCTAGAACC TGGCAGGTTA GAACCTAGAA GGGCTAGAAC CTGGAGAGCC AGAACCTGGA GGGCTAGAAC CTGGAAGGGC TAGAACCTGT AGAGCTAGAA CATGGAGAGC TAGAACCCGG CAGGCTAGAA CCTGGCAAGC TAGAACCTGG AGGGAATGAA CCTGGAGGGC TAGAACCTGG AGAATGAGAA AAATTTACAT GGCAAAGAGC CCATAAATCC TGACCAATCC AACTCTGAAT TTAAAGCAA AAGCGTGAAA AAAAAGATTC CCTCCTTACC CCCAACCCAC TCTITriCC CACCACCCAC TCTCCTCTGC CTCAGTAAGT ATCTGGAGGA AGAAAACAGG TGAAAGAAGA AGTAAAAACC ATTTAGTATT AGTATTAGAA TGAAGTCAAA CTGTGCCACA CATGGTGAAT GAAAAAAAAA AAAAAGAGGC TGTGTTGT CACACAGGGC AGTCATTCAG CACCAGAGCA CGTGATGGTC TGAGACTCTC TTAGGAGCAG AGCTCTGCCG CAATGGCCAT GTGGGGATCC ACACCTGGTC TGAGGGGCAA CTGAGTCTGC GGGAGAAGAG CGGCCCTATG CATGGTGTAG ATGCCCTGAT AAAGAACATC TGTCCTGTGA AAGACTCAAT GAGCTGTrAT GTTGTAAACA GGAAGCATTT CACATCCAAA CGAGAAAATC ATGTAAACAT GTGTCIrMIC TGTAGAGCAT AATAAATGGA TGAGGTT GCAAAAAAAA AAAAAAAAA -3' (FRAG. NO:2275) (SEQ. ID NO:2444) 5'- GAGCTCTTCA ATATITTAGT GAAAGCTATA GATGAGGCTC CATAGGGGAT AAAGCACAGA CACACCIT CAGAGGGCTT GTGGACTCTG GGCAGCCTGT CCATAGACCT CTGTCCCCAA CTGGCAAGTC AGGAAACTCC AGATTAAGGA GCCCCAATGT GGTTGAACAG CCAGGTGCAC AGATGAGTCA ACCACACAGC CAGGCCAGGG AGGGCCTTCA CTCAAGAGCC TACAGCCAGT TCACAGCCAA GCCAGGGCTA GCGCCAGGCC ACCCATAAAC TGATCTGAGA CTCTGITTCC CTGTCTCCAT GATGATGGGA TCAGGCTTGA TTGCTGGTTT GTAGGCTTGT TATGAATCAA GTCACAGGGA AGAGGAGCTG ATGGGCTGGG GGGACGTCCT CTGGCCCTCC TGTCTCTrCC CCAGATCCAC TGGGCCCACT CTTATCTGTT CTCTTCTGAA GGAAGGGTTT TAAGGCTTCA AAAAAAAATG T111GAAAGT CCCTGCCCTT TCCAGCTCCT ACCGTCTCAG CCCTGGGAGT GTAAAGTGCT GCAGATAGTT AGTAAGTCTT TGAGCAAAAC TGAGAAAGCC AGCCTGAGCC TTGACATGGG AGAAACCTCC GCCATACATC TCCGAAGAAA CGGCCGCGTG TCTCAGGGGA GCGCAAACAC CCGTACCCAG GAAACAGGAC AGCTTCTGCC ACTGTCGCCC TTGGGAGCCG TACGTGGCAT GACAAAGAAA TCCCAGGACT CCGCCTGCCC ACCTGGCCAC CCTCTGT=TA CACCTrCCGC GTAAACGCCC ACTGTTTACA TCCAAAACTC AGACACAAAA TAACCACCTC AAGAAGATAA ATAATGATAA GAAATAAATG TrACGCGAGG CAAAITATT CACATGGGGC TTCCCAGGCC ACTTGTGGT CAGCCGGGAG GGACG1 ITI GCCGTCCCAC GACTCCAACG GGCAGCCGGG CCTACGCAAA CATGGAAATC TTCCAAGAGC CTCCCTGGCC CCCAGGGCTC AGAGGGTGGC AGAGCGGAGA GCGAAGGTGG CCGCAGCCTT CCCGGCCCCA CAGCCAGCCT GGCTCCAGCT GGGCAGGAGT GCAGAGCTCA GCTGGAGGCG AGGGGGAAGT GCCCAGGAGG CTGATGACAT CACTACCCAG CCCTTCAAAG ATGAGCTGTT CCCGCCGCCA CTCCAGCTCT GGCTTCTGGG CTCCGAGGAG GGGTGGGGAC GGTGGTGACG GTGGGGACAT CAGGCTGCCC CGCAGTACCA GGGAGCGACT GAAGTGCCCA TGCCGCTTGC TCCGGAGAAG GTGGGTGCCG GGCAGGGGCT GCTCCAGCCG CCTCACCTCT GCTGGGAGGA CAAACTGTCC CAGCACAGAG GGAGGGAGGG AGGGCAGGCA GCGGGGAGAA GTTTCCCTGT GGTCGTGGGG AGTTGGGAAA AGTTCCCTTC CTCCGGAGG GAGG -3'(FRAG. NO:2275) (SEQ. ID NO:2443) 5'- GCCCTTCAAA GATGAGCTGT TCCCGCCGCC ACTCCAGCTC TGGCTTCTGG GCTCCGAGGA GGGGTGGGGA CGGTGGTGAC GGTGGGGACA TCAGGCTGCC CCGCAGTACC AGGGAGCGAC TGAAGTGCCC ATGCCGCTTG CTCCGGAGAA GGTGGGTGCC GGGCAGGGGC TGCTCCAGCC GCCTCACCTC TGCTGGGAGG ACAAACTGTC CCAGCACAGA GGGAGGGAGG GAGGGCAGGC AGCGGGGAGA AGTTTCCCTG TGGTCGTGGG GAGTT -3' (FRAG. NO:2275) (SEQ. ID NO:2442) 5'- AAATGATAGA CCGTCAATAA TTTGTrAAAT GC-TTAAA ATGAATGCTT TAAGCCGGGT GCAGTGCCTC ACATCTGTAA TCCCAGCACT TTGGAGCCGA GCGGGTGGAT TGTGTGAGGT CAGGAGTTCG AGACCAACCT GGCCAACATG GCAAAACCTC ACTCTCTACC AAAAATACAA AAATTAGCCA GGCATGGTGG CAGGCACCTG TGATCCCAGC TACTCAGGAG GCTGAGACAG WO 00/09525 PCT/1JS99/17712 EPI-1 09 242 GAGAATCGCTr TGAACCCGGG AGGCAAGG17 GCAGTGAGCC AAGAT7ACGC CATTGTACTC CAGCCTGGGT GACAGAGAGA GACTCCGTCTr CAAAAAAAAA AAAAAAAAAA AAAAAATTAC GC17CAAACA CATGATCTCT CACCACTG Tr GAATT1CT7 TCTATGAGCC CAGGAGGGCC TCTCAGAGAG GAAAGCTCCT AGGTMTCCT TTCCCTCTGC AAACTCCCTG CC11GAAGGT TCAGAAGGAC TGTGCGTGC T CGTTGCATCC MTGCAAGTG TCCAAACCCT GATCCCAGCT GTGcTTAGGG GTTCCTGCAA. ACCTIICCA GGTGTrAATT ACCTCCCACT TCA 1TCCTG 'IMACCAACT CAGCTI1TG TITAGTGTG 'TTGAA17CC CTGAACTGAC CGT7GTCTGA TCTCCACCTC CCAACTGAAT TAGGGGAGCT GGGCITCTGG AAACCCAGGT GCCGGGTGTr GCAGAGTGGC TGAAAGCTGG GATGTGGCAG ATCCGTGGCT ACAT7CATGC ACACACACAC ACCCACATAC CCACACATGC ACACACACAC ACACACCCGC ACTCACACAC TrGGACATGC ATAGACCACA GCMTCCACA CCCTrCCTAG ACAGGGGTCA CITGGTATCC TGGAGAGAGT GTGAAGTCCT GGAATGGAAA GAGGGGGGAT TAAGCCCCAC CTCTAGCCAT GGGACTGAGA CAAGTCACCA CCAACCCATC TGCGC=~GT TrACCTCCTC TGTGAGGCAA. GCACAGAGCC CATGCCTGCC CCCGTrGGATG GGAGTGATGT GAAACTTGAA GGGCGGTCAG AGCAAGGGTC GGGAATGGAA GGCCCTTGGG AAAAAAGGCC CM~CAACTA GGGGCACAGA GGAGGCCCTG GGC~rGAGAAC 7TGACAGCAC CTTGTAA17G GTAAGCCAAG CCCGAAGGGA CTGGAAATAC TCAGATGTGT CTrGTCTCCCT TATFAGGTTC AAAGTCCCTrC AAGACCCTrGT CTCCATCACA GTGCTCCAGT CCAGACCCCT CCTCTrGAGC T CCAGACCCTG CTGGACCCAA CCAGCCCTAT GGGGTCGCAT CCCCACCTrGC CTGGAATTCT CCAAAGAACC TCCCCI I IAA CAGTrCCAGC C1TAACAGT TCCAGTCTrAA ACACATGACC TTCTCC TCT AAATCAGCCC CCCATC TCTG CC'ITGCAGG AGATGGAAGC CATGACACCT GCCTCGCCCC TGTCCTCACC CCATCCATGT CCAATCAAGC ACTAGGCATG TCAGGnITAC CCTrCTAAACT CCTCTGGAAT CCAGTC TCTC AGTCTCCATC ATCCCAGGTC GAAGCTAATG GGCTAACTGG TCCT'rGCTTC CACTCTACCC CCACTrGCAGT CCTGACTrCC TGAGCAGCAG CCAGGGCCTA ATCGATATFC ACACCAAGCG CCAACCTGAC TGAGATATCC TCC TGCACCA TCATCCCTCC ACCCTG'1A GTrC TGCTCA CCCTCAGTGT TCTCATCAAT AATCCACTCC CCTCACAGGC GCGTTrGGGA CCCCATGTFrC TATGCTCTCA CAGGACCM~ TGCTrGAFTT TITCACTGTAC TrAGGTCAGT rrGCAGTrAT TAAGTGACTG AGCAATGTCT GGCTTCTCCA GTAGACTGTC AGCTCCTAGC CATTGTATAC CTAGCACCGC TGTGTGGGAG CACGTGACAA ACGTCCAGTG AGTCAGGGAC TCAGCAGTCT CCATT17CTCC GCCCTGCTGG AGAATGCGTG TATFITGGCAA TCCCCAGCCC CTGTGCCATC TAACCATCfl TrCTrCTCTG TTCAGCCCAG GTGTGGCCTC ACTCACATCC CACTCTGAGT CCAAATGTTC TCTCCCTGGA AGATATCAAT G=~CTGTCT GTT'CGTGAGG ACTCCGTGCC CACCACGGCC TCMhCAGGT GAGTCAAAGG GA'17CCTCAG FITCACTAGTT AGGGGAGGTG GGCAGACACC CTGGAGAACT CCCTGGAAAG CTCAACTCTrC ATGCCCCGGA CAACAGT7GA AGGAACCATG GTGATGTrAA GCCCAAAGAC AAAACCTCTC AGGTGTCCAA GTCCCTGT7G GAATCTGGG AGCAGAGGGA ATGTTCTGTG GTCTAGAGGA AGAGGGGCTrC AGGGAGGAGA AGGGCACAT7 CCTGGTTGTr ATATGTCT ATCTATCCCA GATGAACTFG GAAGTGAAGG GAAGAGAGT17 AAACATrAAA GTAAATACCC AGTGGATCAG ACAGCAATGT GCCAGATTGC CTTGGAAACA AAATATCTCC AACACATGGC TGACATTGG TGGGAGATCA GAACACCCTA AAGAGAGAAT TrAAGGGGAG GGGGAGGAGG ACCTGAGCCA GAGTAGAAGC AGAGGATAGG GAGATCTGTT CT7GGGGACA GCAMrGCAA GAAACAAGGC TGAGGGGTCC ACTCCAACCT CTCCACCCTrG CTGCAGGTGC TGCC TATGAT GAAGATGAGC AGATGGCCAT CTrCAGCTGGG GCCACAGTGC ACTGGACCUrA TAGMTCCAA TTCCGCACTC AGCAGGCATC 'I=CTGATGA TCCGATGGCT TCTCAGAGCC AGGGATGGGC CAGGATCCAT CCCCF~rGGCT ACTGTCTTGC TGAGAAATT ATAAGCAGCA TCTrGGTGCTA TACTIGGTC T~~rAGTGAGT TAGCTCATGA AAGATGATAG ACTrCTCCAAG CCAGGGGTAT GCAGGAAATG GGTIICTGT AGCTACAGAA ATGGGGTrGA GGGT7GGACC AAGGGACTAC CCAGGGGAAG TCTTACC TrC AGAGGACTCT GGAAAGGAGG CTGCAAGTr TCATGGGTCA AGAATTCAGA GCCCAGTAGA GACAGCTTAT CTC TGTrCCA AGATGTCTrGG GGCC 1TGGTFT GGAAGAfl7CA AAGGCrAGGA AACCAGGAGC CACCAAAAGC GTAACTrGGGG CCAGAGGATC CAC ITCAAG GTGGCAAGTr GGTrCCCCCC ATGTGGC TGC ITFGAGTATCC TCACATGGCG GCTrCACATCC T7CCAAGTAA GCAATGCAAA AGGCCAAGAA AGATGC~rGCA AAGATGflAT GACCTrAGCCT CAGAAATCAC ACACCATCCC TGCCACCATT AGTAAGAAGT CCAGCCCACG TCCAGGAGAA GAGGAAGCAG A'ITCC TCCTT TTGAAATGAA GAATATCAAG TAA1TCGGGG GGCATATGAA AGCCACCACA CACCACAGGG ATCTFITAG AGCATACTI'C TTATACCATC ACTGTAGITC CTAAGACTC AGGGGCAAAG CCTCACTTCC TTAGCACCCA GTGAAGACCA CGCTTACTCC CTCACTrCAAC CTCTGCTAC T7CCCACCTC TCCTrGTCCAA. CATCTAGTGT CAC'IMCCAG AACATACCAA CAGCT7CCCC AGTTCTGTGC CTCTGCTCAG GCTGTrCCCC CTGCCTGGTC CACTGTCCT C=TCITGTC CGGTCAAAAT GC17CTTATC CTICAAGACC CAGCTrCTAGA GTCACCTCCA ACCCCTrACC CACCAGCCCC CTCTCCAAGT CTGTGTCCCA CAACCCCCCT GCTCCCTCCA GGGCACCCTC CACCCTrCTGG GCCACAGTTG TCAGGAGTCA GGCAGGGCAG GGGCCGGGTG GTGT==CT TGTGTTCTTG CACTCAGGGC AGAGCTCAGC ACAGAGCAGA CGCTCAAAAA ACA ITAAAG GATAGAAGCA 'ITGA=TGTG GGTCCCCCAG TCTGGCTCCA GGATGCCAGC CAGCTGCTCC TAGAAGCAAA CGGACTITC CTGGGAAATC CCAGAGGTGA TGATCAGTAA TCTrCTCCCG1T GACTCGTAGT TCAGCTCTC CTrCCATGAGC CTGACTATCA GTGGACCTIC CAGAAAGAGC CCCrI=CCT TCTCTCACCC ACAGCACAGG GCACTGGGAA AATGCCCAAT GAGTCCTGCC TCTGGGTI'GT GCTTT7GGACT 'TCAGTGTG TCTCGCATCC ACTCTTCAAC T7GAATG'rrG CAACAGCCAT GAAAAAAGAA ATGCAAAGCG ATTCAGGATG AGAGCAATAC CCTACTCCAA AGAAGGCAAC ATAGAAGCTrC AGAGAGATCA AGCAAMrGC CCAAGACCAC ACAGCTAGGA GTGGAACTCA TGGCTGTCCA AGCCCCATGC CTCTGCTGAA GGTAGAGATG AA'ITACAGCA ACAAGTCIAG AAAGGTGCCT GCCC TATGGT CTGTGAGTCT TGCCTAAGAA TGAAAGAGGA GCCAGTGGGT TAAAGATGAG GTCACCAACA ACGGTGGTGT TGGAG IT]7AC CACTGATAAT AAGGGTGCAA AATGTAAATr ACTAATGMT A7FGAGCCTA GTGCAGTGCG TGGGGCAnV7 TGCACATTGT CTrCTGATCCC TATGACAACC CTGAGAGGTA GTGGTITAA CTGCCATG T7 ACAGGTGAGG TCATTGTGGT TCAAGGACGT TAAGTAACT7 CCCCAGCGTG ACACGGCIA TAAGTAAGGC AGCCAGGATG TGAACCCAGT AGGACTATCT GGCTGCAAAG TCCCCACCCC CCTrCGCCATC TGTATCCTCC AATCACI1'CA GTGC'IMGCTr GCATAGAAGG TAACGGAAAT CACGATGCCA CAGACTGTCC AGGAAGACAG AAACTAGGCA GATGGGCTGG CCATGGTCTC CAAGCCAGAC TGGAATCTrCC AGGTCTGGAA. TGATATCAT7 lnrCrCrI= AATAAATTAA CTCACCCACC ACACGGC'lM GAGAGGCTCA AAG'ITGACCA ACTCCCTTGG GAGGGCCCCG GTrGATAAGG AAGGAACGTG AATCCTCCCA TCACGGAAGC 17CAAGGAGG TCAAGGGTCC AACACTlGAG ATrGTTAG1TG CTGT7GGTGG ATACTGGCCA AGGAAATATC CCAGTGGAGC CTCGAGATGA AGAACATGAG GCCCCCGTIT AGAACCAAGG ATCAGAGGGG GCTCTGTAAG ACCCAGGGGA GTCAGGTGCA CTGGAGCGCG GGCATGCAGA AAACAGCCTG AGCTCCACCT CGGC'rTCTCC TrGTCCTGGC TGGT-rGTCCT TAACCCCTGT CTCCCGG ACCAGITr= GTCC11rCCCT TGTGACCGCTr GAGGGGTAAC AGCCTCMTC CACTMTIT CAGCGCCGAC ATGCTFCAATG TCACCTTGCA AGGGCCCACT CITAACGGGA CC rTGCCCA GAGCAAATGC CCCCAAGTGG AGTGGCTGGG CTGGCTrCAAC ACCATCCAGC CCCCCTICCT CTGGGTGCTG T7CGTGCTGG CCACCCTAGA GAACATCIT GTCCTCAGCG TCTCTGCCT GCACAAGAGC AGCTGCACGG TGGCAGAGAT CTACCTGGGG AACCTGGCCG CAGCAGACCT GATCCTGGCC TGCGGGCTGC CC TCTGGGC CATCACCATC TCCAACAACT TCGACTGGCTr C'ITGGGGAG ACGCTCTGCC GCGTGGTGAA TGCCATFATC TCCATGAACC TGTACAGCAG WO 00/09525 PCT/US99/17712 EPI-109 243 CATCTGTTTC CTGATGCTGG TGAGCATCGA CCGCTACCTG GCCCTGGTGA AAACCATGTC CATGGGCCGG ATGCGCGGCG TGCGCTGGGC CAAGCTCTAC AGCTrGGTGA TCTGGGGGTG TACGCTGCTC CTGAGCTCAC CCATGCTGGT GTTCCGGACC ATGAAGGAGT ACAGCGATGA GGGCCACAAC GTCACCGCTr GTGTCATCAG CTACCCATCC CTCATCTGGG AAGTGTTCAC CAACATGCTC CTGAATGTCG TGGGCTTCCT GCTGCCCCTG AGTGTCATCA CCTTCTGCAC GATGCAGATC ATGCAGGTGC TGCGGAACAA CGAGATGCAG AAGTrCAAGG AGATCCAGAC GGAGAGGAGG GCCACGGTGC TAGTCCTGGT TGTGCTGCTG CTATTCATCA TCTGCTGGCT GCCCTCCAG ATCAGCACCT TCCTGGATAC GCTGCATCGC CTCGGCATCC TCTCCAGCTG CCAGGACGAG CGCATCATCG ATGTAATCAC ACAGATCGCC TCCTTCATGG CCTACAGCAA CAGCTGCCTC AACCCACTGG TGTACGTGAT CGTGGGCAAG CGCTrCCGAA AGAAGTCTTG GGAGGTGTAC CAGGGAGTGT GCCAGAAAGG GGGCTGCAGG TCAGAACCCA TTCAGATGGA GAACTCCATG GGCACACTGC GGACCTCCAT CTCCGTGGAA CGCCAGATTC ACAAACTGCA GGACTGGGCA GGGAGCAGAC AGTGAGCAAA CGCCAGCAGG GCTGCTGTGA ATTrGTGTAA GGATTGAGGG ACAGTTGCTr TTCAGCATGG GCCCAGGAAT GCCAAGGAGA CATCTATGCA CGACCTTGGG AAATGAGTTG ATGTCTCCGG TAAAACACCG GAGACTAATT CCTGCCCTGC CCAATTTTGC AGGGAGCATG GCTGTGAGGA TGGGGTGAAC TCACGCACAG CCAAGGACTC CAAAATCACA ACAGCATTAC TGTTCTTATT TGCTGCCACA CCTGAGCCAG CCTGCTCCTT CCCAGGAGTG GAGGAGGCCT GGGGGCAGGG AGAGGAGTGA CTGAGCPTCC CTCCCGTGTG TTCTCCGTCC CTGCCCCAGC AAGACAACTT AGATCTCCAG GAGAACrGCC ATCCAGCTTT GGTGCAATGG CTGAGTGCAC AAGTGAGTTG TTGCCCTGGG TTTCITTAAT CTATTCAGCT AGAACTTGA AGGACAATTT CTTGCATTAA TAAAGGTTAA GCCCTGAGGG GTCCCTGATA ACAACCTGGA GACCAGGATT TTATGGCTCC CCTCACTGAT GGACAAGGAG GTCTGTGCCA AAGAAGAATC CAATAAGCAC ATATTGAGCA CTTGCTGTAT ATGCAGTATT GAGCACTGTA GGCAAGAGGG AAGAAAGAGA AGGAGCCATC TCCATCTTGA AGGAACTCAA AGACTCAAGT GGGAACGACT GGGCACTGCC ACCACCAGAA AGCTGTTCGA TGAGACGGTC GAGCAGGGTG CTGTGGGTGA TATGGACAGC AGAAGGGGGA GCCAGGTTCC AGCTCACCAA TACTATTGCA CACCACCTGT CCTGCCTC -3' (FRAQ. NO: _) (SEQ. ID NO 2441) 5'-CAGATCACA AACTGCAGGA CTGGGCAGGG AGCAGACAGT GAGCAAACGC CAGCAGGGCT GCTGTGAATT TGTGTAAGGA TTGAGGGACA GTTGCT11C AGCATGGGCC CAGGAATGCC AAGGAGACAT CTATGCACGA CCTTGGGAAA TGAGTTGATG TCTCCGGTAA AACACCGGAG ACTAATTCCT GCCCTGCCCA ATTGCAGG GAGCATGGCT GTGAGGATGG GGTGAACTCA CGCACAGCCA AGGACTCCAA AATCACAACA GCATTACTGT TCTTAITTGC TGCCACACCT GAGCCAGCCT GCTCCTCCC AGGAGTGGAG GAGGCCTGGG GGGAGGGAGA GGAGTGACTG AGCTTCCCTC CCGTGTGTTC TCCGTCCCTG CCCCAGCAAG ACAACT7AGA TCTCCAGGAG AACTGCCATC CAGCTTGGT GCAATGGCTG AGTGCACAAG TGAGTTGTTG CCCTGGGTTT CTTTAATCTA TTCAGCTAGA ACTTGAAGG ACAATTTCTT GCATTAATAA AGGTrAAGCC CTGAGGGGTC CCTGATAACA ACCTGGAGAC CAGGA1111A TGGCTCCCCT CACTGATGGA CAAGGAGGTC TGTGCCAAAG AAGAATCCAA TAAGCACATA TTGAGCACTT GCTGTATATG CAGTATTGAG CACTGTAGGC AAGACCCAAG AAAGAGAAGG AGCCATCTCC ATCTTGAAGG AACTCAAAGA CTCAAGTGGG AACGACTGGG CACTGCCACC ACCAGAAAGC TGTTCGACGA GACGGTCGAG CAGGGTGCTG TGGGTGATAT GGACAGCAGA AGGGGGAGAC CAAGGTTCCA GCTCAACCAA TAACTATTGC ACAACCACCT GTCCCTGCCT CAGTTCCCTT TTATGTAACA TGAAGTCGTT GTGAGGGTTA AAGGCAGTAA CAGGTATAAA GTACTTAGAA AAGCAAAGGG TGCTACGTAC ATGTGAGGCA TCATTACGCA GACGTAACTG GGATATGMTT ACTATAAGGA AAAGACACTG AGGTCTAGAA ATAGCTCCGT GGAGCAGAAT CAGTATrGGG AGCCGGTGGC GGTGTGAAGC ACCAGTGTCT GGCACACAGT AGGTGCTCAT TGGCTCCCT CCACCTGTCA TTCCCACCAC CCTGAGGCCC CAACCGCCAC ACACACAGGA GCATTGGAG AGAAGGCCAT GTCTTCAAAG TCTGA'TTGT GATGAGGCAG AGGAAGATAT TTCTAATCGG TCTTGCCCAG AGGATCACAG TGCTGAGACC CCCCACCACC AGCCGGTACC TGGGAAGGGG GAGAGTGCAG GCCTGCTCAG GGACTGTTCC TGTCTCAGCA ACCAAGGGAT TGTTCCTGTC AATCAATGGT TTATTGGAAG GTGGCCCAGT ATGAGCCCTA GAAGAGTGTG AAAAGGAATG GCAATGGTGT TCACCATCGG CAGTGCCAGG GCAGCACTCA TTCACTTGAT AAATGAATAT TTATTAGCTG GTTGGAGAGC TAGAACCTGG AGAGCTAGAA CCTGGAGAAC TAGAACCTGG AGGGCTAGAA CCTGGAGAGG CTAGAACCAA GAAGGGCTAG AACCTGGAGG GGCTAGAACC TAGAGAAGCT AAAACCTGAG CTAGAAGCTG GAGGACTAGA ACCTGGAGGG CTGGAATCTG AAGGGCTAGA ACCTGGAGGG CTGGAATCTG GAGAGCTAGA ACCTGGAGGG CTAGAACCTG GAGGGCTAGA ACCTAGAAGG GCTAGAACCT GGAGGGCTGG AATCTGGAGA GCTAGAACCT GGAGGGCTAG AACCTGGAGG GCTAGAACCT AGAAGGGCTA GAACCTGGAG GGCTAGAACC TGGCAGGT7A GAACCTAGAA GGGCTAGAAC CTGGAGAGCC AGAACCTGGA GGGCTAGAAC CrGGAAGGGC TAGAACCTGT AGAGCTAGAA CATGGAGAGC TAGAACCCGG CAGGCTAGAA CCTGGCAAGC TAGAACCTGG AGGGAATGAA CCTGGAGGGC TAGAACCTGG AGAATGAGAA AAATACAT GGCAAAGAGC CCATAAATCC TGACCAATCC AACTCTGAAT TAAAGCAA AAGCGTGAAA AAAAAGATTC CCTCCTTACC CCCAACCCAC TCITITITCC CACCACCCAC TCTCCTCTGC CTCAGTAAGT ATCTGGAGGA AGAAAACAGG TGAAAGAAGA AGTAAAAACC ATTTAGTATT AGTATrAGAA TGAAGTCAAA CTGTGCCACA CATGGTGAAT GAAAAAAAAA AAAAAGAGGC TGTGTTTGT CACACAGGGC AGTCATTCAG CACCAGAGCA CGTGATGGTC TGAGACTCTC TTAGGAGCAG AGCTCTGCCG CAATGGCCAT GTGGGGATCC ACACCTGGTC TGAGGGGCAA CTGAGTCTGC GGGAGAAGAG CGGCCCTATG CATGGTGTAG ATGCCCTGAT AAAGAACATC TGTCCTGTGA AAGACTCAAT GAGCTGT7AT GTTGTAAACA GGAAGCATTT CACATCCAAA CGAGAAAATC ATGTAAACAT GTGTCUITTC TGTAGAGCAT AATAAATGGA TGAGG'FnTr GCAAAAAAAA AAAAAAAAA -3' (FRAQ. NO: _) (SEQ. ID NO 2431) 5'-GGTGBCBTTGBGCBTGTCGGCGC-3' (FRAG. NO:2276) (SEQ. ID NO:2287) 5'-GGTCCCGTTBBGBGTGGGCCC-3' (FRAG. NO:2277) (SEQ. ID NO:2288) 5'-GCCAGCCCAGCCACTCCACTTGGGGGC-3' (FRAG. NO:2278) (SEQ. ID NO:2289) 5'-GGGTGGCCAGCACGAACAGCACCCAGAGGAAGGGGGGC-3' (FRAG. NO:2279) (SEQ. ID NO:2290) 5'-GGCCCAGAAGGGCAGCCCGCAGGCCAGGATCAGGTCTGCTGCGGCC-3' (FRAG. NO:2280) (SEQ. ID NO:2291) 5'-GGAGATAATGGCATTCACCACGCGGC-3' (FRAG. NO:2281) (SEQ. ID NO:2292) 5'-GGCCCAGCGCACGCCGCGCATCCGGCCC-3' (FRAG. NO:2282) (SEQ. ID NO:2293) 5'-GGGTTCTGACCTGCAGCCCCC-3' (FRAG. NO:2283) (SEQ. ID NO:2294) 5'-GTCTCCTTGGCATTCCTGGGCCC-3' (FRAG. NO:2284) (SEQ. ID NO:2295) 5'-CAGTCACTCCTCTCCCTGCCCCC-3' (FRAG. NO:2285) (SEQ. ID NO:2296) 5'-CTTGCTGGGGCAGGGACGG-3' (FRAG. NO:2286) (SEQ. ID NO:2297) 5'-GGTGBCBTTGBGCBTGTCGGCGC-3' (FRAG. NO:2287) (SEQ. ID NO:2298) 5'-GGTCCCGTTBBGBGTGGGCCC-3' (FRAG. NO:2288) (SEQ. ID NO:2299) 5'-GCCAGCCCAGCCACTCCACTTGGGGGC-3' (FRAG. NO:2289) (SEQ. ID NO:2300) WO 00/09525 PCT/US99/17712 EPI-109 244 5'-GGGTGGCCAGCACGAACAGCACCCAGAGGAAGGGGGGC-3' (FRAG. NO:2290) (SEQ. ID NO:2301) 5'-GGCCCAGAAGGGCAGCCCGCAGGCCAGGATCAGGTCTGCTGCGGCC-3' FRAGG. NO:2291) (SEQ. ID NO:2302) 5'-GGAGATAATGGCATTCACCACGCGGC-3' (FRAG. NO:2292) (SEQ. ID NO:2303) 5'-GGCCCAGCGCACGCCGCGCATCCGGCCC-3' FRAGG. NO:2293) (SEQ. ID NO:2304) 5'-GGGTTCTGACCTGCAGCCCCC-3' (FRAG. NO:2294) (SEQ. ID NO:2305) 5'-GTCTCCTTGGCATTCCTGGGCCC-3' (FRAG. NO:2295) (SEQ. ID NO:2306) 5'-CAGTCACTCCTCTCCCTGCCCCC-3' (FRAG. NO:2296) (SEQ. ID NO:2307) 5'-CTTGCTGGGGCAGGGACGG-3' (FRAG. NO:2297) (SEQ. ID NO:2308) 5'-CCGTG TTGTCBGTGGTGCTG-3' (FRAG. NO:2298) (SEQ. ID NO:2309) 5'-CCCGTTTGBGGTBTGGC-3' (FRAG. NO:2299) (SEQ. ID NO:2310) 5'-GCTCCBCCBBTTCCCTTTTCTCC-3' (FRAG. NO:2300) (SEQ. ID NO:2311) 5'-TTGTTTTCCGTTTCTCTTG-3' (FRAG. NO:2301) (SEQ. ID NO:2312) 5'-CCGTCTGTGGTI-3' (FRAG. NO:2302) (SEQ. ID NO:2313) 2 Adrenergic Receptor Kinase Nucleic Acids and Antisense Oli2onucleotide Fragments 5'- GCCGCCGCCG CCAAGATGGC GGACCTGGAG GCGGTGCTGG CCGACGTGAG CTACCTGATG GCCATGGAGA AGAGCAAGGC CACGCCGGCC GCGCGCGCCA GCAAGAAGAT ACTGCTGCCC GAGCCCAGCA TCCGCAGTGT CATGCAGAAG TACCTGGAGG ACCGGGGCGA GGTGACCT=T GAGAAGATCT TTTCCCAGAA GCTGGGGTAC CTGCTCTTCC GAGACTTCTG CCTGAACCAC CTGGAGGAGG CCAGGCCCTT GGTGGAATTC TATGAGGAGA TCAAGAAGTA CGAGAAGCTG GAGACGGAGG AGGAGCGTGT GGCCCGCAGC CGGGAGATCT TCGACTCATA CATCATGAAG GAGCTGCTGG CCTGCTCGCA TCCCTTCTCG AAGAGTGCCA CTGAGCATGT CCAAGGCCAC CTGGGGAAGA AGCAGGTGCC TCCGGATCTC TTCCAGCCAT ACATCGAAGA GATTTGTCAA AACCTCCGAG GGGACGTGTT CCAGAAATTC ATTGAGAGCG ATAAGrrCAC ACGGTTITGC CAGTGGAAGA ATGTGGAGCT CAACATCCAC CTGACCATGA ATGACTTCAG CGTGCATCGC ATCATTGGGC GCGGGGGCTT TGGCGAGGTC TATGGGTGCC GGAAGGCTGA CACAGGCAAG ATGTACGCCA TGAAGTGCCT GGACAAAAAG CGCATCAAGA TGAAGCAGGG GGAGACCCTG GCCCTGAACG AGCGCATCAT GCTCTCGCTC GTCAGCACTG GGGACTGCCC ATTCATTGTC TGCATGTCAT ACGCGTTCCA CACGCCAGAC AAGCTCAGCT TCATCCTGGA CCTCATGAAC GGTGGGGACC TGCACTACCA CCTCTCCCAG CACGGGGTCT TCTCAGAGGC TGACATGCGC TTCTATGCGG CCGAGATCAT CCTGGGCCTG GAGCACATGC ACAACCGCTT CGTGGTCTAC CGGGACCTGA AGCCAGCCAA CATCCTTCTG GACGAGCATG GCCACGTGCG GATCTCGGAC CTGGGCCTGG CCTGTGACT7 CTCCAAGAAG AAGCCCCATG CCAGCGTGGG CACCCACGGG TACATGGCTC CGGAGGTCCT GCAGAAGGGC GTGGCCTACG ACAGCAGTGC CGACTGGTTC TCTCTGGGGT GCATGCTCTT CAAGTTGCTG CGGGGGCACA GCCCCTTCCG GCAGCACAAG ACCAAAGACA AGCATGAGAT CGACCGCATG ACGCTGACGA TGGCCGTGGA GCTGCCCGAC TCCTTCTCCC CTGAACTACG CTCCCTGCTG GAGGGGTTGC TGCAGAGGGA TGTCAACCGG AGATTGGGCT GCCTGGGCCG AGGGGCrCAG GAGGTGAAAG AGAGCCCCTT TrTCCGCTCC CTGGACTGGC AGATGGTCTT CTTGCAGAAG TACCCTCCCC CGCTGATCCC CCCACGAGGG GAGGTGAACG CGGCCGACGC CTrCGACATT GGCTCCTTCG ATGAGGAGGA CACAAAAGGA ATCAAGTTAC TGGACAGTGA TCAGGAGCTC TACCGCAACT TCCCCCTCAC CATCTCGGAG CGGTGGCAGC AGGAGGTGGC AGAGACTGTC TrCGACACCA TCAACGCTGA GACAGACCGG CTGGAGGCTC GCAAGAAAGC CAAGAACAAG CAGCTGGGCC ATGAGGAAGA CTACGCCCTG GGCAAGGACT GCATCATGCA TGGCTACATG TCCAAGATGG GCAACCCCTr CCTGACCCAG TGGCAGCGGC GGTACTCTA CCTGTTCCCC AACCGCCTCG AGTGGCGGGG CGAGGGCGAG GCCCCGCAGA GCCTGCTGAC CATGGAGGAG ATCCAGTCGG TGGAGGAGAC GCAGATCAAG GAGCGCAAGT GCCTGCTCCT CAAGATCCGC GGTGGGAAAC AGTFCAT1T GCAGTGCGAT AGCGACCCTG AGCTGGTGCA GTGGAAGAAG GAGCTGCGCG ACGCCTACCG CGAGGCCCAG CAGCTGGTGC AGCGGGTGCC CAAGATGAAG AACAAGCCGC GCTCGCCCGT GGTGGAGCTG AGCAAGGTGC CGCTGGTCCA GCGCGGCAGT GCCAACGGCC TCTGACCCGC CCACCCGCCT CCAGGAAGCT ACCTGGAGGA GGTGAGTCTT AGCGGATGAG TAGGAGTrGT CCACGGAGGA AGGTACACAG AAGGGCTTCC AGGCCCAGGA AACAGCAGAG GCACAGAAGT GAGAATGGGT GGGTGAGTTG GTGGGGAAAC TCCAGGTGCA GAGGATGGTA GCGAAACAAA CTGGAGCATT AAGGTCCAAG TCCTCCAAGA TCTTGACTTG CAGATTAAGG AGTTTGTTCA CCTAATCTGC 1TTGGGCAGA GTGTGGTGAG TCCTAGAGAC CCCTCTAGGT CTCTCCTCrC AGTAGCCCCA GAAGGCCTGG AGAGCTGCTT CTGGGTGCCA AGCAGGCAGT GACTCCATCA GATCTAGATT TGGGAAAAGC ATCCCTGGTC AGGGCCTGCA TCAGGGCAGT GGCTGGCCAT GAGGACCCTG AGAAGTAGAC AGATTCACGG AGATTCTCAG GAGGCCAGAC AGGAGACTAT GGTGACAAAT TAGATrAGAG AAGGGGAGAG AATGAAGGAG CAGTrGGGGT AAAAGAAAAC TGAGGCTGAC ATGGGTATAT GGGTGGCGAG TGACTCACCA CCCACTGAGA GGAGAACCTC ACAAGCTCTG ACATGCTCTG GTTCCAGGTr CTGTTGGGGC TGATCCAAGA TGGTAGCCTA GAGGTGCACA GAGATGGGGG CCr7G=CTG CAAAAGGATG CTGGCTGCTG GCCCACAGCA TGGTAATGAG ATTTGAGCTr TATGTGCCCA GGGCTGGGAG GAGGGTCCTG TCACTTGAA AGCAAAGAGA GGCTCTAGAG AGGGGCATGT TGAGATAGGA ATGCTGCCTT GAGACACCTG GCTTTCCCCA CTCTGGGTGG CTCTCAGCAG GGTGGGTTTC CCCTGCCAGG CAGCACTGAA CCTCTGTGCG CTTCCGGCTG GGAGAGTTT TACCGTAACT ACATGTGGAA CCATCCTGAA GGAACATCTG GATGGGATGG GGTACAGGGA AGGGAGCTGC CAAGAGTGCT GGCCAGGGAC CTGGGTCTAT GAGCTGGTTG GGGGGTGGGG TrGGGTGCAG GGTACTrGAT CCTGAGTGGG CCTTCTGCGG CCAGGATTGG TTCTAGAGTA GGAGGGGTGG GATCGGGGAT GGGGGAAGCC TGTAACTGCG CTGCAGTTGT CAGGTCCCAG GTTCTGGGTG ACCTACTAAG GATTCTGGGT CCAGTGTGGG TCCCAGGTTA GACGTCCTAG TCCTGAGTCC GTGTCCACAG TTCTGGGTGT TGAGTCTAGG ACAGTGATCT GGAGTTGACA GTCCAATCTA GGTCTGAGTC CTGACCCCAA GTCTAGAGTT CAGGGTCATG GTAGTAGCCT AGGGTCAGAA TCAAGGTTGG GGTCAGTAAC CAGGATGGGA TCGAGGTCAT GGTCCAAAAT CTGGATCTGG GGACCTGTTG GGGGTCTGAG GTGAGTGTCG CAGTCTGGGT ATGGCGTTGG AGACCCAGGG CTGTGATCTG AGGTCATGGT TAGAGTCTCA GGTGGTGGGC CAAGGTTTGA GTCTGGGGTC CTGITTGGAG TCTGGTGTCA GGTCGTGGAC TGCGTCCAAG GTCAGGGAGT CCGGGGTTAT AGCCAGGGTC TGAGATGAAA GTCCCAGATG GTGTTCAGAG GTCTGAATCT GTGTCTTGGT GAGCGTCCAG GTTCCCTGTG ATCACGTTTG GTGTCAGGGC TGCGGCCCGA CTGGGGAGCC TGGGATCCAG AGATGTGACC CGAGGTTGTG GTCAGAGAAT GGGTCTCGGG TCGTCTTCGT GCCGGGTCCC TGTCGTGTrC CAGGCCCGGG TCTCCGTCCA GCATCGAGGG CCGAGGTCAC GGCCAGGGTC TGAGCCCGCG GTCGCAGGTC TGGTTCGGGG TCAGATTCCG CGCGGCCTCC AGGGGGCGCC GTCGCCGCCC GGCTCGGCCC CTCGCGGGCT CGCTGGCGTT GTGCGCGGCA GGCGGGGCCG WO 00/09525 PCT/US99/17712 EPI-109 245 GAGGCGGCGG CGGCTCCGGG GGCGCGGGCC GGGCGGCGGC GGCGGCGGCG CCCCGACTGC AGTCCCGGCG GGAGCGGAGC GCGAAGCGCG GGGCCGGGCC CGGAGCCGGC GCCATGGGGC GGCGCCGCCT GTGAGCGGCG GCGAGCGGAG CCGCGGGCGC CGAGCAGGGC CAGGCGGGAG CGTCGGCGCC CGAGGCCGAG CGAGCCGCGG CCGGGCCGGG CCGAGCGCCG AGCGAGCAGG AGCGGCGGCG GCGGCGGCGG CGGCGGGAGG AGGCAGCGCC GCCGCCAAGA TGGCGGACCT GGAGGCGGTG CTGGCCGACG TGAGCTACCT GATGGCCATG GAGAAGAGCA AGGCCACGCC GGCCGCGCGC GCCAGCAAGA AGATACTGCT GCCCGAGCCC AGGTGAGGAG AAGCT-3' (FRAG. NO:_) (SEQ. ID NO:2430) 5'-CCAGGAAGCT ACCTGGAGGA GGTGAGTCTT AGCGGATGAG TAGGAGTrGT CCACGGAGGA AGGTACACAG AAGGGCTTCC AGGCCCAGGA AACAGCAGAG GCACAGAAGT GAGAATGGGT GGGTGAGTTG GTGGGGAAAC TCCAGGTGCA GAGGATGGTA GCGAAACAAA CTGGAGCATT AAGGTCCAAG TCCTCCAAGA TCTTGACTTG CAGATTAAGG AGTITGTCA CCTAATCTGC T~rGGGCAGA GTGTGGTGAG TCCTAGAGAC CCCTCTAGGT CTCTCCTCTC AGTAGCCCCA GAAGGCCTGG AGAGCTGCTT CTGGGTGCCA AGCAGGCAGT GACTCCATCA GATCTAGATT TGGGAAAAGC ATCCCTGGTC AGGGCCTGCA TCAGGGCAGT GGCTGGCCAT GAGGACCCTG AGAAGTAGAC AGATrCACGG AGATTCTCAG GAGGCCAGAC AGGAGACTAT GGTGACAAAT TAGATTAGAG AAGGGGAGAG AATGAAGGAG CAGTUGGGGT AAAAGAAAAC TGAGGCTGAC ATGGGTATAT GGGTGGCGAG TGACTCACCA CCCACTGAGA GGAGAACCTC ACAAGCTCTG ACATGCTCTG GTTCCAGGTT CTGTTGGGGC TGATCCAAGA TGGTAGCCTA GAGGTGCACA GAGATGGGGG CCTTGCTG CAAAAGGATG CTGGCTGCTG GCCCACAGCA TGGTAATGAG ATTTGAGCTT TATGTGCCCA GGGCTGGGAG GAGGGTCCTG TCACrTGAA AGCAAAGAGA GGCTCTAGAG AGGGGCATGT TGAGATAGGA ATGCTGCCTT GAGACACCTG GCTTCCCCA CTCTGGGTGG CTCTCAGCAG GGTGGGTrC CCCTGCCAGG CAGCACTGAA CCTCTGTGCG CTTCCGGCTG GGAGAGTT TACCGTAACT ACATGTGGAA CCATCCTGAA GGAACATCTG GATGGGATGG GGTACAGGGA AGGGAGCTGC CAAGAGTGCT GGCCAGGGAC CTGGGTCTAT GAGCTGGTTG GGGGGTGGGG TTGGGTGCAG GGTACTTGAT CCTGAGTGGG CCTTCTGCGG CCAGGATTGG TTCTAGAGTA GGAGGGGTGG GATCGGGGAT GGGGGAAGCC TGTAACTGCG CTGCAGTTGT CAGGTCCCAG GTTCTGGGTG ACCTACTAAG GATTCTGGGT CCAGTGTGGG TCCCAGGTTA GACGTCCTAG TCCTGAGTCC GTGTCCACAG TTCTGGGTGT TGAGTCTAGG ACAGTGATCT GGAGTTGACA GTCCAATCTA GGTCTGAGTC CTGACCCCAA GTCTAGAGTT CAGGGTCATG GTAGTAGCCT AGGGTCAGAA TCAAGGTTGG GGTCAGTAAC CAGGATGGGA TCGAGGTCAT GGTCCAAAAT CTGGATCTGG GGACCTGTTG GGGGTCTGAG GTGAGTGTCG CAGTCTGGGT ATGGCGTTGG AGACCCAGGG CTGTGATCTG AGGTCATGGT TAGAGTCTCA GGTGGTGGGC CAAGGTTTGA GTCTGGGGTC CTGTTTGGAG TCTGGTGTCA GGTCGTGGAC TGCGTCCAAG GTCAGGGAGT CCGGGGTTAT AGCCAGGGTC TGAGATGAAA GTCCCAGATG GTGTTCAGAG GTCTGAATCT GTGTCTTGGT GAGCGTCCAG GTTCCCTGTG ATCACGTTTG GTGTCAGGGC TGCGGCCCGA CTGGGGAGCC TGGGATCCAG AGATGTGACC CGAGGTTGTG GTCAGAGAAT GGGTCTCGGG TCGTCTTCGT GCCGGGTCCC TGTCGTGTTC CAGGCCCGGG TCTCCGTCCA GCATCGAGGG CCGAGGTCAC GGCCAGGGTC TGAGCCCGCG GTCGCAGGTC TGGTTCGGGG TCAGATTCCG CGCGGCCTCC AGGGGGCGCC GTCGCCGCCC GGCTCGGCCC CTCGCGGGCT CGCTGGCGTT GTGCGCGGCA GGCGGGGCCG GAGGCGGCGG CGGCTCCGGG GGCGCGGGCC GGGCGGCGGC GGCGGCGGCG CCCCGACTGC AGTCCCGGCG GGAGCGGAGC GCGAAGCGCG GGGCCGGGCC CGGAGCCGGC GCCATGGGGC GGCGCCGCCT GTGAGCGGCG GCGAGCGGAG CCGCGGGCGC CGAGCAGGGC CAGGCGGGAG CGTCGGCGCC CGAGGCCGAG CGAGCCGCGG CCGGGCCGGG CCGAGCGCCG AGCGAGCAGG AGCGGCGGCG GCGGCGGCGG CGGCGGGAGG AGGCAGCGCC GCCGCCAAGA TGGCGGACCT GGAGGCGGTG CTGGCCGACG TGAGCTACCT GATGGCCATG GAGAAGAGCA AGGCCACGCC GGCCGCGCGC GCCAGCAAGA AGATACrGCT GCCCGAGCCC AGGTGAGGAG AAGCT-3' (FRAG. NO:_) (SEQ. ID NO:2429) 5'-GCCGCCGCCG CCAAGATGGC GGACCTGGAG GCGGTGCTGG CCGACGTGAG CTACCTGATG GCCATGGAGA AGAGCAAGGC CACGCCGGCC GCGCGCGCCA GCAAGAAGAT ACTGCTGCCC GAGCCCAGCA TCCGCAGTGT CATGCAGAAG TACCTGGAGG ACCGGGGCGA GGTGACCTT GAGAAGATCT TTTCCCAGAA GCTGGGGTAC CTGCTCTTCC GAGACTTCTG CCTGAACCAC CTGGAGGAGG CCAGGCCCTr GGTGGAATTC TATGAGGAGA TCAAGAAGTA CGAGAAGCTG GAGACGGAGG AGGAGCGTGT GGCCCGCAGC CGGGAGATCT TCGACTCATA CATCATGAAG GAGCTGCTGG CCTGCTCGCA TCCCTTCTCG AAGAGTGCCA CTGAGCATGT CCAAGGCCAC CTGGGGAAGA AGCAGGTGCC TCCGGATCTC TTCCAGCCAT ACATCGAAGA GATGTCAA AACCTCCGAG GGGACGTGTT CCAGAAATTC ATTGAGAGCG ATAAGTTCAC ACGGTTGC CAGTGGAAGA ATGTGGAGCT CAACATCCAC CTGACCATGA ATGACTTCAG CGTGCATCGC ATCATTGGGC GCGGGGGCTT TGGCGAGGTC TATGGGTGCC GGAAGGCTGA CACAGGCAAG ATGTACGCCA TGAAGTGCCT GGACAAAAAG CGCATCAAGA TGAAGCAGGG GGAGACCCTG GCCCTGAACG AGCGCATCAT GCTCTCGCTC GTCAGCACTG GGGACTGCCC ATTCATTGTC TGCATGTCAT ACGCGTTCCA CACGCCAGAC AAGCTCAGCT TCATCCTGGA CCTCATGAAC GGTGGGGACC TGCACTACCA CCTCTCCCAG CACGGGGTCT TCTCAGAGGC TGACATGCGC TTCTATGCGG CCGAGATCAT CCTGGGCCTG GAGCACATGC ACAACCGCTT CGTGGTCTAC CGGGACCTGA AGCCAGCCAA CATCCTTCTG GACGAGCATG GCCACGTGCG GATCTCGGAC CTGGGCCTGG CCTGTGACT CTCCAAGAAG AAGCCCCATG CCAGCGTGGG CACCCACGGG TACATGGCTC CGGAGGTCCT GCAGAAGGGC GTGGCCTACG ACAGCAGTGC CGACTGGTTC TCTCTGGGGT GCATGCrCTT CAAGTrGCTG CGGGGGCACA GCCCCTTCCG GCAGCACAAG ACCAAAGACA AGCATGAGAT CGACCGCATG ACGCTGACGA TGGCCGTGGA GCTGCCCGAC TCCTTCTCCC CTGAACTACG CTCCCTGCTG GAGGGGTTGC TGCAGAGGGA TGTCAACCGG AGATTGGGCT GCCTGGGCCG AGGGGCTCAG GAGGTGAAAG AGAGCCCCTT ITTCCGCTCC CTGGACTGGC AGATGGTCTr CTTGCAGAAG TACCCTCCCC CGCTGATCCC CCCACGAGGG GAGGTGAACG CGGCCGACGC CTTCGACATT GGCTCCTTCG ATGAGGAGGA CACAAAAGGA ATCAAGTTAC TGGACAGTGA TCAGGAGCTC TACCGCAACT TCCCCCTCAC CATCTCGGAG CGGTGGCAGC AGGAGGTGGC AGAGACTGTC 'TTCGACACCA TCAACGCTGA GACAGACCGG CTGGAGGCTC GCAAGAAAGC CAAGAACAAG CAGCTGGGCC ATGAGGAAGA CTACGCCCTG GGCAAGGACT GCATCATGCA TGGCTACATG TCCAAGATGG GCAACCCCTT CCTGACCCAG TGGCAGCGGC GGTACTTCTA CCTGTrCCCC AACCGCCTCG AGTGGCGGGG CGAGGGCGAG GCCCCGCAGA GCCTGCTGAC CATGGAGGAG ATCCAGTCGG TGGAGGAGAC GCAGATCAAG GAGCGCAAGT GCCTGCTCCT CAAGATCCGC GGTGGGAAAC AGTTCATT GCAGTGCGAT AGCGACCCTG AGCTGGTGCA GTGGAAGAAG GAGCTGCGCG ACGCCTACCG CGAGGCCCAG CAGCTGGTGC AGCGGGTGCC CAAGATGAAG AACAAGCCGC GCTCGCCCGT GGTGGAGCTG AGCAAGGTGC CGCTGGTCCA GCGCGGCAGT GCCAACGGCC TCTGACCCGC CCACCCGCCT-3' (FRAG. NO:_) (SEQ. ID NO:2428) CCR-2 CC Chemokine Receptor Nucleic Acids and Antisense Oli2onucleotide Fragments 5'-CTTGTGAAG AAGGAATTGG CAACACTGAA ACCTCCAGAA CAAAGGCTGT CACTAAGGTC CCGCTGCCT GATGGATTAT ACACTTGACC TCAGTGTGAC AACAGTGACC GACTACTACT ACCCTGATAT CTTCTCAAGC CCCTGTGATG CGGAACTTAT TCAGACAAAT GGCAAGTTGC TCC=TGCTGT CTTTATTGC CTCCTGTTG TATTCAGTCT TCTGGGAAAC AGCCTGGTCA TCCTGGTCCT TGTGGTCTGC AAGAAGCTGA GGAGCATCAC AGATGTATAC CTCTTGAACC TGGCCCTGTC WO 00/09525 PCT/US99/1 7712 EPI- 109 246 TGACCTGM T7 FTGTC'rCT C=~CCCC'I TCAGACCTAC TATCTGCTGG ACCAGTGGGT GT11rGGGACT GTAATGTGCA AAGTGGTGTC TGGC'ITIAT TACATrGG~r TCTACAGCAG CATG~fTTC ATCACCCTCA TGAGTGTGGA CAGGTACCTrG GCTGTTGTCC ATGCCGTGTA TGCCCTAAAG GTGAGGACGA TCAGGATGGG CACAACGCTG TGCCTGGCAG TATGGCTAAC CGCCA17ATG GCTACCATCC CAT7GCTAGT GTITACCAA GTGGCCTCTG AAGATGGTGT TCTACAGTGT TATTCA FT ACAATCAACA GAC'TGAAG TGGAAGATCT TCACCAACrr CAAAATGAAC ATITAGGCT TGflrGATCCC ATTCACCATC 7rrATG'rrCT G~TACATTAA AATCCTGCAC CAGCrGAAGA GGTGTCAAAA CCACAACAAG ACCAAGGCCA TCAGGTTGGT GCTCArr1GTG GTCATrGCAT =1TACTFI CTGGGTCCCA TrCAACGTGG TrC7TICCT CACTrCCTTG CACAGTATGC ACATCTTGGA TGGATGTAGC ATAAGCCAAC AGCTGACTTA TGCCACCCAT GTCACAGAAA TCATTIrCCTI' TACTCACTGC TGTGTGAACC CTGTrATCTA TGC=flTr~ GGGGAGAAGT TCAAGAAACA CCTCTCAGAA ATA'IMCAGA AAAGTrGCAG CCAAATCT7C AACTACCTAG GAAGACAAAT GCCTAGGGAG AGCTGTGAAA AGTCATCATC CTGCCAGCAG CACTCCTCCC GT7CCTCCAG CGTAGACTAC ATI=GTGAG GATCAATGAA GACTAAATAT AAAAAACA~r TCTrGAATG GCATGCTAGT AGCAGTGAGC AAAGGTGTGG GTGTGAAAGG 'ITrCCAAAAA AAGTITCAGCA TGAAGGATGC CGTGTGTGT7 GTrGCCAACA CITGGAACAC AATGACTGGA GACATAGTrG TGCATGCCTG GCACAACATC AAGCCTGTGA 7rGTGTIT7AT TGATGATGTr GAACAAGTGG TGGC'TGAG GGAFCTGTA TGCCAAGTGG AAAAAAAAGA TGTCTCCGGA ArrCGACAGG 'ITATCA-3' (FRAG. NO:_) (SEQ. ID NO:2462) CCR-4 CC Chemokine Receptor Nucleic Acids and Antisense Oligonucleotide Fragments 5'-MICATCTCT CCGGGCTFAT T7GCrGGT CTCCGAATGC GGGCCTTGTC TGGTTCACGC TGGATCCCCA ACGCCTAGAA CAGTGCGTGG CACGCAG~FrC GTCCrrCTAT AAATATCGGA CTAAATGCAT CT~TGTGATG GTAATACCCA CACGGTGTrG TGAGAATGAA TGAGTGA TFC TGTGCAAG'IT CCTAGTGATC TGT7ACAAAA AGTACTGGTC GCTAAATrAC TCTTATAATA AAGCATAC Tr AGGATAAT AAAGCACTrAT TCGCGAATI'G GTTACCGCTA T7ATGAAATT ACTGAGCAAT ACATATCrAC ATCTGATCAG TCTCCAGAAT TATGCCAAAT CCTACCI-rCT TCTGAAAGTA TCTCCrAA-r ATCTGCACCT GACCU1TAGTG ATGCTGTGAA TGTGCAAGTA TAGCTACATC CTCCGAAGGA AGGATC'T]A CTCC=rAC CTCCTGAATG GGCTGCGTCT GCTGAAAGCG CGGGGGAATG GGCGGT7GGA AGCTrGGCCC TACITCCAGC ATrGCCGCCT ACTGGTrGGG TrACTCCAGC AAGTCACTCC CCTTCCCTGG GCCTCAGTGT CTCTACTGTA GCA F1CCCAG GTCTGGATr CCATCCACTr TAGCAAGGAT GGACGCGCCA CAGAGAGACG CGT7CCTAGC CCGCGCTTCC CACCTGTCTT CAGGCGCATC CCG=TCCCT CAAACTrAGG AAATGCCTCT GGGAGGTCCT GTCCGGCTCC GGACTCACTA CCGACCACCC GCAAACAGCA GGGTCCCCTG GGCTTCCCAA GCCGCGCACC TCTCCGCCCC GCCCCTGCGC CCTC=CrCc CGCGTCTGCC CCTrCTCCCCC ACCCCGCCTr CTCCCTCCCC GCCCCAGCGG CGCATGCGCC GCGCTrCGGAG CGTGTrTMA TAAAAGTCCG GJCCGCGGCCA GAAACTCAG 'rGTrGGCT GCGGCAGCAG GTAGCAAAGT GACGCCGAGG GCCTGAGTGC TCCAGTAGCC ACCGCATCTG GAGAACCAGC GGTTACCATG GAGGGGATCA GTGTAAGTCC AGT'rCAACC TGC=TIGTCA TAAATGTACA AACGMIIGAA CTrAGAGCGC AGCCCCTcC CGAGCGGGCA GAAGCGGCCA GGACATrGGA GGTACCCGTA CTCCAAAAAA GGGTCACCGA AAGGAGTIT CTrGACCATG CCTATATAGT GCGGGTGGGT GGGGGGGGAG CAGGAflGGA ATCTrITCT CTGTGAGTCG AGGAGAAACG ACTGGAAAGA GCGT7CCAGT GGCTGCATGT GTCTrCCCCCT TGAGTCCCGC CGCGCGCGGC GGCT1rGCACG CTGTI7GCAA ACGTAAGAAC ATrCTGTGCA CAAGTGCAGA GAAGGCGTGC GCGCTGCCTC GGGACTCAGA CCACCGGTCT CrrCc~lrGGG GAAGCGGGGA TGTCITrGGAG CGAG'ITACAT TGTCTGAATT TAGAGGCGGA GGGCGGCGTG CCTGGGCTGA C17CCCAGGA GGAGATrGCG CCCG=rrAA =TCGGGGTT AAGCGCCTGG TGACTGTCT TGACACTGGG TGCGTG'TIG FAAACTrCTG TGCGGCCGAC GGAGCTGTGC CAGTCTCCCA GCACAGTAGG CAGAGGGCGG GAGAGGCGGG TGGACCCACC GCGCCGATCC TCTGAGGGGA TCGAGTGGTG GCAGCAGCTA GGAGTrGATC CGCCCGCGCG C1TGGG7Tr GAGGGGGAAA C=TCCCGCC GTCCGAAGCG CGCCT=~CC CCACGGCCGC GAGTGGGTCC TGCAGTrCGA GAGMTGGGG TCGTGCAGAG GTCAGCGGAG TGGT,1TGACC TCCCCTIGA CACCGCGCAG CTGCCAGCCC TGAGA'IT1GC GCTCCGGGGA TAGGAGCGGG TACGGGGTGA GGGGCGGGGG CGGT7AAGAC CGCACCTGGG CTGCCAGGTC GCCGCCGCGA AGACTGGCAG GTGCAAGTGG GGAAACCGT7 TGGCTCTCTC CGAGTCCAGT TGTGATGMT AACCGTCGGT GG'T1TCCAGA AACCTIIGA AACCCTC=G CTAGGGAGTr 1TrGG ICC TGCAGCGGCG CGCAATFCAA AGACGCTCGC GGCGGAGCCG CCCAGTCGCT CCCCAGCACC CTGTGGGACA GAGCCTGGCG TGTCGCCCAG CGGAGCCCCT GCAGCGCTGC ITFGCGGGCGG 'FrGGCGTGGG TGTAGTGGGC AGCCGCGGCG GCCCGGGGCT GGACGACCCG GCCCCCCGCG TGCCCACCGC CTGGAGGCTI' CCAGCTGCCC ACCTCCGGCC GGGTTAACTG GATCAGTGGC GGGGTAATGG GAAGCCACCC GGGAGAGTGA GGAAATGAAA CTGGGGCGA GGACCACGGG TGCAGACCCC GTrACCTTCT CCACCCAGGA AAATGCCCCG CTCCCTAACG TCCCAAACGC GCCAAGTGAT AAACACGAGG ATGGCAAGAG ACCCACACAC CGGAGGAGCG CCCGCITGGG GGAGGAGGTG CCGMIGTrC A=IICTGAC ACTCCCGCCC AATATACCCC AAGCACCGAA GGGCCICGT =I~AAGACCG CATTCTTT ACCCACTACA AGTrGCTTGA AGCCCAGAAT GG'ITGTAT7 TAGGCAGGCG TGGGAAAAT'r AAGTTIGC GC'TAGGAG AATGAGTC11 TGCAACGCCC CCGCCCTCCC CCCGTGATCC TCCcTrTCTCC CCTCTTCCCT CCCTGGGCGA AAAACTrCIT ACAAAAAGYI' AATCACTGCC CCTCCTAGCA GCACCCACCC CACCCCCCAC GCCGCCTGGG AGTGGCCTCT TrGTGTGTAT T77rrl=fC CTCCTAAGGA AGGTTITI TCTrCCCTCT AGTGGGCGGG GCAGAGGAGT TAGCCAAGAT GTGACTT7GA AACCCTCAGC GTCTCAGTGC CCITIG7rC TAAACAAAGA ATITGTAAT TGGTTCTACC AAAGAAGGAT ATAATGAAGT CACTATGGGA AAAGATGGGG AGGAGAGTrG TAGGATFCTA CA~rAATlCT C17GTGCCCT TAGCCCACTA CF7CAGAAfl TCCTGAAGAA AGCAAGCCrG AATTGGITI'T AAAMTGCI T7AAAAA T]17 'TrMAACTG GG~rAATGCT TGCTGAAflG GAAGTGAATG TCCATTCCF7 TGCCTCFIT GCAGATATAC AcTTCAGATA ACrACACCGA GGAAATGGGC TCAGGGGACT ATGACTCCAT GAAGGAACCC TGT11CCGTG AAGAAAATGC TAAn7ICAAT AAAATCTTCC TGCCCACCAT CTACTCCATC ATC-17TAA CTGGCA17GT GGGCAATGGA TrGGTCATCC TGGTCATGGG TrACCAGAAG AAACTGAGAA GCATGACGGA CAAGTACAGG CTGCACCTGT CAGTGGCCGA CCTCCTC'= GTCATCACGC T'rCCCrrCTGGGCAGTTGAT GCCGTGGCAA ACTGGTACTI7 TGGGAA=TC CTATGCAAGG CAGTCCATGT CATCTACACA GTCAACCTCT ACAGCAGTGT CCTCATCCTG GCCTTCATCA GTCTGGACCG CTACCTGGCC ATCGTCCACG CCACCAACAG TCAGAGGCCA AGGAAGCTGT TGGCrGAAAA GGTGGTCTAT G'TrGGCGTCT GGATCCCTGC CCTCCTGCTG ACTAT7CCCG A=TCATCTTr TGCCAACGTC AGTGAGGCAG ATGACAGATA TATCTGTGAC CG=~CTACC CCAATGACIr GTGGGTGGT GTGTTCCAGT TrCAGCACAT CATGGTlGGC CTTATCCTGC CTGGTA77GT CATCCTGTCC TGCTA'ITGCA TTATCATCTC CAAGCTGTCA CACTCCAAGG GCCACCAGAA GCGCAAGGCC CTCAAGACCA CAGTCATCCT CATCC'GGCT 7TCTTCGCCT G F7GGCTGCC TTACTACAT GGGATCAGCA TCGACTCCTr CATCCTCCTG GAAATCATCA AGCAAGGGTG TGAGTrGAG AACACTGTGC ACAAGTGGAT TrCCATCACC GAGGCCCTAG Cr=CT7CCA CTGT7GTCTG AACCCCATCC TCTATGCTI CCIGGAGCC AAA TrFAAAA CCTCTGCCCA GCACGCACTC ACCTCTGTGA GCAGAGGGTC CAG3CCTCAAG ATCCTCTCCA AAGGAAAGCG AGGTGGACAT TCATCTGTIT CCACTGAGTC TGAGTCTTCA AG=FTCACT CCAGCTAACA CAGATGTAAA WO 00/09525 PCT/US99/17712 EPI-109 247 AGAC1TT TTATACGATA AATAACTT 'TTAAGTrA CACAT]TC AGATATAAAA GACTGACCAA TATTGTACAG T-1TATGC TTGTTGGATr TTGTCTTGT GTTTCTTTAG T=ITGTGAA GTAATTGA CTTATATA TAAATTr TTGTCATA TTGATGTGTG TCTAGGCAGG ACCTGTGGCC AAGTTCTTAG TTFGCTGTATG TCTCGTGGTA GGACTGTAGA AAAGGGAACT GAACATTCCA GAGCGTGTAG TGAATCACGT AAAGCTAGAA ATGATCCCCA GCTGTTTATG CATAGATAAT CTCTCCATTC CCGTGGAACG TTCCTGT TCTTAAGACG TGATTTTGCT GTAGAAGATG GCAC'TATAA CCAAAGCCCA AAGTGGTATA GAAATGCTGG TITITCAGTT TTCAGGAGTG GGTTGATTrC AGCACCTACA GTGTACAGTC TTGTATTAAG TrGTrAATAA AAGTACATGT TAAACTIACT TAGTGTTATG TTCTGATTTC TGTTGACATT CTTTTGGCTA GTAGAAGACA AAAGTAATAC ATTATGGTA TGCAAAGCAC TATCCTAGGT AITTCATrGT AATATITTAC TTACCCCTTA TCACAACTCT GATAGATTCT GCTTCTGTTA CTAATTACAT TTATAGAAG AGGAAACGGA GGCACAGAAA GCCTAAGTAA CTrGGTTAAA GGCATGTAGT AAGTATCAAA TCCTGTATr TAAACCAGGT AACATGACTT AACGAATCTG AAGCCTTCAC CACTTAAAT TCAAATGGAA GTAGAAAT GGCCAGCCAG CACCTATTG TATGAAAGGT CATC=TTCAG AGGATAAGCA TGTATAAAGA AGAAAAGGTA TGCAGTCGTG TTGGATTTT ACTCCACCAT C-3' (FRAG. NO:_) (SEQ. ID NO: 2463) CD-34 Nucleic Acids and Antisense OliLonucleotide Fragments 5'-AGGATGATGG TGATGGGGAA CTAAATGGGG AAATATGGAA GGTCACAGGA AAAGTTAACA CAAGTrAGCA AAAGTITAAC ATAACACAAA AAGGTCTTGC AGGAAAAAAA AAAGAAAAGA AAAGAAAGAA AAAGTCTCCA AGAATGGTTT GGACAGCCAA AATGAATACT TATAGTCACG TATACCTGCT CACTCCTGAC GCTTCACTCA CACACAGCAC AGGATCTGGT GAGGCTATCA TAAATGTGC CACATTGTGG TTAAGTTrA CCTGATTAAC GAAATGCTCA CACTrCTAAA CTGAGGTCCT TACAGTAGAT TCC-ITGCA AGATTGTTAC TGGCTrACAA CTTAAAAATA AAGGAAAATC ACAAGGAAAG AAAAGTGGGG AAAAAATCGG AGGAAACTTG CCCCTGCCCT GGCCACCGGC AAGGCTGCCA CAAAGGGGTT AAAAGTrAAG TGGAAGTGGA GCTTGAAGAA GTGGGATGGG GCCTCTCCAG GAAAGCTGAA CGAGGCATCT GGAGCCCGAA CAAACCTCCA CCTTTGG CCTCGACGGC GGCAACCCAG CCTCCCTCCT AACGCCCTCC GCCTTTGGGA CCAACCAGGG GAGCTCAAGT TAGTAGCAGC CAAGGAGAGG CGCTGCCTrG CCAAGACTAA AAAGGGAGGG GAGAAGAGAG GAAAAAAGCA AGAATCCCCC ACCCCTCTCC CGGGCGGAGG GGGCGGGAAG AGCGCGTCCT GGCCAAGCCG AGTAGTGTCT TCCACTCGGT GCGTCTCTCT AGGAGCCGCG CGGGAAGGAT GCTGGTCCGC AGGGGCGCGC GCGCAGGGCC CAGGATGCCG CGGGGCTGGA CCGCGCTTTG CTTGCTGAGT TTGCTGC CCTTTTGG CCTCGACGGC GGCAACCCAG CCTCCCTCCT AACGCCCTCC GCCTTGGGA CCAACCAGGG GAGCTCAAGT TAGTAGCAGC CAAGGAGAGG CGCTGCCTTG CCAAGACTAA AAAGGGAGGG GAGAAGAGAG GAAAAAAGCA AGAATCCCCC ACCCCTCTCC CGGGCGGAGG GGGCGGGAAG AGCGCGTCCT GGCCAAGCCG AGTAGTGTCT TCCACTCGGT GCGTCTCTCT AGGAGCCGCG CGGGAAGGAT GCTGGTCCGC AGGGGCGCGC GCGAGGGCCC AGGATGCCGC GGGGCTGGAC CGCGCTTGC TTGCTGAGTT TGCTGCCTrC TGGGTTCATG AGTCTTGACA ACAACGGTAC TGCTACCCCA GAGTTACCTA CCCAGGGAAC ATTTTCAAAT GTTTCTACAA ATGTATCCTA CCAAGAAACT ACAACACCTA GTACCCTTGG AAGTACCAGC CTGCACCCTG TGTCTCAACA TGGCAATGAG GCCACAACAA ACATCACAGA AACGACAGTC AAATTCACAT CTACCTCTGT GATAACCTCA GTTTATGGAA ACACAAACTC TrCTGTCCAG TCACAGACCT CTGTAATCAG CACAGTGTrC ACCACCCCAG CCAACGTTTC AACTCCAGAG ACAACCTTGA AGCCTAGCCT GTCACCTGGA AATGTTTCAG ACCTTCAAC CACTAGCACT AGCCTTGCAA CATCTCCCAC TAAACCCTAT ACATCATCT CTCCTATCCT AAGTGACATC AAGGCAGAAA TCAAATGTTC AGGCATCAGA GAAGTGAAAT TGACTCAGGG CATCTGCCTG GAGCAAAATA AGACCTCCAG CrGTGCGGAG TAAGAAGG ACAGGGGAGA GGGCCTGGCC CGAGTGCTGT GTGGGGAGGA GCAGGCTGAT GCTGATGCTG GGGCCCAGGT ATGCTCCCTG CTCCTTGCCC AGTCTGAGGT GAGGCCTCAG TGTCTACTGC TGGTCTTGGC CAACAGAACA GAAAT1TCCA GCAAACTCCA ACTTATGAAA AAGCACCAAT CTGACCTGAA AAAGCTGGGG ATCCTAGATr TCACTGAGCA AGATGTTGCA AGCCACCAGA GCTATrCCCA AAAGACCCTG ATTGCACTGG TCACCTCGGG AGCCCTGCTG GCTGTCTTGG GCATCACTGG CTATTTCCTG ATGAATCGCC GCAGCTGGAG CCCCACAGGA GAAAGGCTGG GCGAAGACCC TTATTACACG GAAAACGGTG GAGGCCAGGG CTATAGCTCA GGACCTGGGA CCTCCCCTGA GGCTCAGGGA AAGGCCAGTG TGAACCGAGG GGCTCAGAAA AACGGGACCG GCCAGGCCAC CTCCAGAAAC GGCCATTCAG CAAGACAACA CGTGGTGGCT GATACCGAAT TGTGACTCGG CTAGGTGGGG CAAGGCTGGG CAGTGTCCGA GAGAGCACCC CTCTCTGCAT CTGACCACGT GCTACCCCCA TGCTGGAGGT GACATCTCTT ACGCCCAACC CTTCCCCACT GCACACACCT CAGAGGCTGT TCTTGGGGCC CTACACCTrG AGGAGGGGGC AGGTAAACTC CTGTCCITTA CACATTCGGC TCCCTGGAGC CAGACTCTGG TCTTCTTTGG GTAAACGTGT GACGGGGGAA AGCCAAGGTC TGGAGAAGCT CCCAGGAACA ATCGATGGCC TTGCAGCACT CACACAGGAC CCCCTTCCCC TACCCCCTCC TCTCTGCCGC AATACAGGAA CCCCCAGGGG AAAGATGAGC 'TTCTAGGC TACAAT=C TCCCAGGAAG CTGATITT TACCGTTCT TCCCTGTATT TTC1TTCTCT ACTTTGAGGA AACCAAAGTA ACC1ITGCA CCTGCTCTCT TGTAATGATA TAGCCAGAAA AACGTGTTGC CTTGAACCAC TrCCCTCATC TCTCCTCCAA GACACTGTGG ACTTGGTCAC CAGCTCCTCC CTTGTrCTCT AAGTTCCACT GAGCTCCATG TGCCCCCTCT ACCAITTTGCA GAGTCCTGCA CAGrMTTCTG GCTGGAGCCT AGAACAGGCC TCCCAAGTM TAGGACAAAC AGCTCAGTTC TAGTCTCTCT GGGGCCACAC AGAAACTCTT TTTGGGCTCC 1-ITICTCCC TCTGGATCAA AGTAGGCAGG ACCATGGGAC CAGGTCTTGG AGCTGAGCCT CTCACCTGTA CTCTCCGAA AAATCCTCTr CCTCTGAGGC TGGATCCTAG CCTTATCCTC TGATCTCCAT GGCTTCCTCC TCCCTCCTGC CGACTCCTGG GTTGAGCTGT TGCCTCAGTC CCCCAACAGA TGCTTTTCTG TCTCTGCCTC CCTCACCCTG AGCCCCTTCC TTGCTCTGCA CCCCCATATG GTCATAGCCC AGATCAGCTC CTAACCCTTA TCACCAGCTG CCTCTTCTGT GGGTGACCCA GGTCCTTGTr TGCTGTTGAT TTCTTTCCAG AGGGGTTGAG CAGGGATCCT GGMTTCAATG ACGGTTGGAA ATAGAAATTT CCAGAGAAGA GAGTATTGGG TAGATATFT TrCTGAATAC AAAGTGATGT GTAAATAC TGCAATrAAA GTGATACTGA AACAC-3' (FRAG. No:_) (SEQ. ID NO:2466) 5'-AGGATGATGG TGATGGGGAA CTAAATGGGG AAATATGGAA GGTCACAGGA AAAGTTAACA CAAGTTAGCA AAAAGTTAAC ATAACACAAA AAGGTCTTGC AGGAAAAAAA AAAGAAAAGA AAAGAAAGAA AAAGTCTCCA AGAATGGTT GGACAGCCAA AATGAATACT TATAGTCACG TATACCTGCT CACTCCTGAC GCTTCACTCA CACACAGCAC AGGATCTGGT GAGGCTATCA CTAAATGTGC CACATTGTGG TrAAGTTTA CCTGATTAAC GAAATGCTCA CACTTCTAAA CTGAGGTCCT TACAGTAGAT TCCITTGCA AGATrGTTAC TGGCTTACAA CTTAAAAATA AAGGAAAATC ACAAGGAAAG AAAAGTGGGG, AAAAAATCGG AGGAAACTrG CCCCTGCCCT GGCCACCGGC AAGGCTGCCA CAAAGGGGTT AAAAGThAAG TGGAAGTGGA GCTTGAAGAA GTGGGATGGG GCCTCTCCAG GAAAGCTGAA CGAGGCATCT GGAGCCCGAA CAAACCTCCA CITIIIIGG CCTCGACGGC GGCAACCCAG CCTCCCTCCT AACGCCCTCC GCC=GGGA CCAACCAGGG GAGCTCAAGT TAGTAGCAGC CAAGGAGAGG CGCTGCCTTG CCAAGACTAA AAAGGGAGGG GAGAAGAGAG GAAAAAAGCA AGAATCCCCC ACCCCTCTCC CGGGCGGAGG GGGCGGGAAG AGCGCGTCCT GGCCAAGCCG AGTAGTGTCT TCCACTCGGT GCGTCTCTCT AGGAGCCGCG CGGGAAGGAT GCTGGTCCGC AGGGGCGCGC GCGCAGGGCC CAGGATGCCG CGGGGCTGGA CCGCGCIIG CTTGCTGAGT T7GCTGC-3' (FRAG. NO:_) (SEQ. ID NO:2464) 5'-CCITITrTGG CCTCGACGGC GGCAACCCAG CCTCCCTCCT AACGCCCTCC GCCTTTGGGA CCAACCAGGG GAGCTCAAGT TAGTAGCAGC CAAGGAGAGG CGCTGCCTTG CCAAGACTAA AAAGGGAGGG GAGAAGAGAG GAAAAAAGCA AGAATCCCCC ACCCCTCTCC CGGGCGGAGG GGGCGGGAAG AGCGCGTCCT GGCCAAGCCG AGTAGTGTCT TCCACTCGGT WO 00/09525 PCT/US99/17712 EPI-109 248 GCGTCTCTCT AGGAGCCGCG CGGGAAGGAT GCTGGTCCGC AGGGGCGCGC GCGAGGGCCC AGGATGCCGC GGGGCTGGAC CGCGCTGC TTGCTGAGTT TGCTGCCTTC TGGGTrCATG AGTCTTGACA ACAACGGTAC TGCTACCCCA GAGTTACCTA CCCAGGGAAC ATTTTCAAAT GTTTCTACAA ATGTATCCTA CCAAGAAACT ACAACACCTA GTACCCTTGG AAGTACCAGC CTGCACCCTG TGTCTCAACA TGGCAATGAG GCCACAACAA ACATCACAGA AACGACAGTC AAATTCACAT CTACCTCTGT GATAACCTCA GTTTATGGAA ACACAAACTC TTCTGTCCAG TCACAGACCT CTGTAATCAG CACAGTGTTC ACCACCCCAG CCAACGTITC AACTCCAGAG ACAACCTTGA AGCCTAGCCT GTCACCTGGA AATGTTCAG ACCTTCAAC CACTAGCACT AGCCTTGCAA CATCTCCCAC TAAACCCTAT ACATCATCTT CTCCTATCCT AAGTGACATC AAGGCAGAAA TCAAATGTTC AGGCATCAGA GAAGTGAAAT TGACTCAGGG CATCTGCCTG GAGCAAAATA AGACCTCCAG CTGTGCGGAG TAAGAAGG ACAGGGGAGA GGGCCTGGCC CGAGTGCTGT GTGGGGAGGA GCAGGCTGAT GCTGATGCTG GGGCCCAGGT ATGCTCCCTG CTCCTrGCCC AGTCTGAGGT GAGGCCTCAG TGTCTACTGC TGGTCTTGGC CAACAGAACA GAAATTTCCA GCAAACTCCA ACTTATGAAA AAGCACCAAT CTGACCTGAA AAAGCTGGGG ATCCTAGATT TCACTGAGCA AGATGTTGCA AGCCACCAGA GCTATTCCCA AAAGACCCTG ATTGCACTGG TCACCTCGGG AGCCCTGCTG GCTGTCTTGG GCATCACTGG CTATTrCCTG ATGAATCGCC GCAGCTGGAG CCCCACAGGA GAAAGGCTGG GCGAAGACCC TTATTACACG GAAAACGGTG GAGGCCAGGG CTATAGCTCA GGACCTGGGA CCTCCCCTGA GGCTCAGGGA AAGGCCAGTG TGAACCGAGG GGCTCAGAAA AACGGGACCG GCCAGGCCAC CTCCAGAAAC GGCCATTCAG CAAGACAACA CGTGGTGGCT GATACCGAAT TGTGACTCGG CTAGGTGGGG CAAGGCTGGG CAGTGTCCGA GAGAGCACCC CTCTCTGCAT CTGACCACGT GCTACCCCCA TGCTGGAGGT GACATCTCTT ACGCCCAACC CTTCCCCACT GCACACACCT CAGAGGCTGT TCTTGGGGCC CTACACCTTG AGGAGGGGGC AGGTAAACTC CTGTCCTTA CACATTCGGC TCCCTGGAGC CAGACTCTGG TCTTCTTGG GTAAACGTGT GACGGGGGAA AGCCAAGGTC TGGAGAAGCT CCCAGGAACA ATCGATGGCC TTGCAGCACT CACACAGGAC CCCCTTCCCC TACCCCCTCC TCTCTGCCGC AATACAGGAA CCCCCAGGGG AAAGATGAGC TTTTCTAGGC TACAATTTTC TCCCAGGAAG CTTTGATT TACCGTTTCT TCCCTGTATT TTCTTCTCT ACTTGAGGA AACCAAAGTA ACC-ITrGCA CCTGCTCTCT TGTAATGATA TAGCCAGAAA AACGTGTTGC CTTGAACCAC TTCCCTCATC TCTCCTCCAA GACACTGTGG ACTTGGTCAC CAGCTCCTCC CTTGTTCTCT AAGTTCCACT GAGCTCCATG TGCCCCCTCT ACCATGCA GAGTCCTGCA CAGTITTCTG GCTGGAGCCT AGAACAGGCC TCCCAAGT TAGGACAAAC AGCTCAGTTC TAGTCTCTCT GGGGCCACAC AGAAACTCTT TTTGGGCTCC -ITlCTCCC TCTGGATCAA AGTAGGCAGG ACCATGGGAC CAGGTCTTGG AGCTGAGCCT CTCACCTGTA CTCTTCCGAA AAATCCTCTT CCTCTGAGGC TGGATCCTAG CCTTATCCTC TGATCTCCAT GGCTrCCTCC TCCCTCCTGC CGACTCCTGG GTTGAGCTGT TGCCTCAGTC CCCCAACAGA TGCTITCTG TCTCTGCCTC CCTCACCCTG AGCCCCTTCC TTGCTCTGCA CCCCCATATG GTCATAGCCC AGATCAGCTC CTAACCCTTA TCACCAGCTG CCTCT7CTGT GGGTGACCCA GGTCCTTGTr TGCTGTTGAT TTCTTTCCAG AGGGGTTGAG CAGGGATCCT GGTTTCAATG ACGGTrGGAA ATAGAAATTT CCAGAGAAGA GAGTATTGGG TAGATATTTT TTCTGAATAC AAAGTGATGT GTTTAAATAC TGCAATTAAA GTGATACTGA AACAC-3' (FRAG. No:_) (SEQ. ID NO:2465) Eotaxin Antisense Nucleic Acids and Oligonucleotide Fragments 5'-GCATITITC AAGTTTATG ATTTATTTAA CTTGTGGAAC AAAAATAAAC CAGAAACCAC CACCTCTCAC GCCAAAGCTC ACACCTTCAG CCTCCAACAT GAAGGTCTCC GCAGCACTrC TGTGGCTGCT GCrCATAGCA GCTGCCTTCA GCCCCCAGGG GCTCGCTGGG CCAGCTTCTG TCCCAACCAC CTGCTGCTTT AACCTGGCCA ATAGGAAGAT ACCCCITCAG CGACTAGAGA GCTACAGGAG AATCACCAGT GGCAAATGTC CCCAGAAAGC TGTGATCTTC AAGACCAAAC TGGCCAAGGA TATCTGTGCC GACCCCAAGA AGAAGTGGGT GCAGGATTCC ATGAAGTATC TGGACCAAAA ATCTCCAACT CCAAAGCCAT AAATAATCAC CAIT-TIGAA ACCAAACCAG AGCCTGAGTG TTGCCTAATT TGTTCCCT TCTTACAATG CATTCTGAGG TAACCTCATT ATCAGTCCAA AGGGCATGGG TTATTATA TATATATATA -TITrTr AAAAAAAAAC GTATrGCATT TAATTATTG AGGCTAAA ACTTATCCTC CATGAATATC AGTTA-ITrl AAACTGTAAA GCTGTGCA GATTCTTTAC CCCCTGGGAG CCCCAATTCG ATCCCCTGTC ACGTGTGGGC AATGTTCCCC CTCrCCTCTC TTCCTCCCTG GAATCTTGTA AAGGTCCTGG CAAAGATGAT CAGTATGAAA ATGTCATTGT TCTTGTGAAC CCAAAGTGTG ACTCATTAAA TGGAAGTAAA TGTGTITTA GGAATAC ATGAAGGTCT CCGCAGCACT TCTGTGGCTG CTGCTCATAG CAGCTGCCTT CAGCCCCCAG GGGCTCGCTG GGCCAGCTrC TGTCCCAACC ACCTGCTGCT TTAACCTGGC CAATAGGAAG ATACCCCTTC AGCGACTAGA GAGCTACAGG AGAATCACCA GTGGCAAATG TCCCCAGAAA GCTGTGATCT TCAAGACCAA ACTGGCCAAG GATATCTGTG CCGACCCCAA GAAGAAGTGG GTGCAGGATr CCATGAAGTA TCTGGACCAA AAATCTCCAA CTCCAAAGCC ATAA CCACATATTC CCCTCCT1TT CCAAGGCAAG ATCCAGATGG ATTAAAAAAT GTACCAAGTC CCTCCTACTA GCTTGCCTCT CTrCTGTrCT GCTTGACTTC CTAGGATCTG GAATCTGGTC AGCAATCAGG AATCCCTrCA TCGTGACCCC CGCATGGGCA AAGGCTTCCC TGGAATCTCC CACACTGTCT GCTCCCTATA AAAGGCAGGC AGATGGGCCA GAGGAGCAGA GAGGCTGAGA CCAACCCAGA AACCACCACC TCTCACGCCA AAGCTCACAC CTTCAGCCTC CAACATGAAG GTCTCCGCAG CACTTCTGTG GCTGCTGCTC ATAGCAGCTG CCTrCAGCCC CCAGGGGCTC GCTGGGCCAG GTAAGCCCCC CAACTCCTrA CAGGAAAGGT AAGGTAACCA CCTCCAGGCT ACTAGGTCAG CAAGAATCTT TACAGACrCA CTGCAAATrC TCCATGAA AAATAGGGAA ACAGGT=TTG TGGGTGGACA AGAAATGCCT CAACCGTCAC ATCCAGTCAC TGGAAGAGCC AGAACTAGAA AGCTCCCGAG TCUITCCCC ACATTCAAGA GGGCCGCTGG GTGCATCCT ACCCAGCTAT CCTACAGTG TTGGGAATG GGGAATGGCT CTGTCTTACT GTGGGCATGG TGGGCATIT TGGCAGTGGG AGAGAAGGAA AATCTGTTGA TrAGAAGCTC AGTATGTTAA TrCGACTCCA GGACAGCITT CAGAGACAGT GGCTAAGAGA AGAACGAGGT CCCAGGGGAT CTCTTGAGGT GACTTATlTT GACACTCTTT GGGAAAGTTA TCTAGGAGAT TTGTTCCATA ACTCAT=TTC CCATACTCTG GTGACAAATT TACTGAGTGT ATCGGTCCCA CTGAGCCAGT GCATAGCATG GTAACAAACA G7TCTAAATT ATCAATGACT TAACAGAATT AACTAAATTA ACAAAAGTrA CTTCTCACT TGTACTAAAT ATCTATAATG TATGGGCTCA GGCTTCTGCA TITTATACTC AGGATTCTAG ACTGATGGAG AAGTTGCCAT GTGGGGGAAC ATTGATGGAT ACTGTGATAA AGCAGAAGAA AGCTCTCAGG AGTCTTGCAT AGGCAATGCA CTGTGGCTCA AAAATGACAC CCATCACT GTCTCCTTCT TrATTGATCA AAACTAATrA ATGCCTCCAA CCAAACAAAA GTGGCCAAGA AATGCAAGTC TACCTTGTGT CTCAAAACAG AGGATGGAGA ATATTTGGTG AAAATTACCA TGACCATCAC ATGGCCACGT AGGTCITrAT AATGACAGAG CTAGCATTG TCACATTGAC CAAGCTGT CCATACACTC TACAGTAATG ATGAGTCCTC AGTGCACAGG GGAGGATGCT GAAGACACAG GACAGCATCC TCCAGACACA TAAGACTTCA GAGCAGAGGG ATTCTCCCTC CACCTCTCGC AATTCCTTGC TCTCCTAA CTTCC'TAC AAAGTCATGC TTGGAAATGT CTATGTATCA TCATGTGGCT CAlITnTlTC TCTGTTCATT TTrCCCC AAAATTCAGC TTCTGTCCCA ACCACCTGCT GCTTAACCT GGCCAATAGG AAGATACCCC TTCAGCGACT AGAGAGCTAC AGGAGAATCA CCAGTGGCAA ATGTCCCCAG AAAGCTGTGA TGTAAGTAAA TAAAGTTCAC CCTCCCCTAG ACAAAAAAAT AATGTCTAGG GCACAGAGTC AAGAACTGTG GGAGTCATAG ACTCTGATAG TI7GACCTCT ATGGTCCAAT TCATTAAT TCACAAGTGA GTGTTCACTC CCAGCTCCCT GCCTGGGAGA WO 00/09525 PCT/US99/17712 EPI-109 249 TTGCTGTAGT CATATCAATT TCTTCAAGTC AAGAGCAAAG ATGGTTTAC TGGGCCTTTA AGAGCAGCAA CTAACCCAAG AGTCTCATCC TTCCTCCTCT CCGTAGCAAC CCTGTCCA GGGGCAGATG GTCCTTAAAT AMAGGGTC AAATGGGCAG AATITCAAA AACAATCCTT CCAATTGCAT CCTGATTCTC CCCACAGCTr CAAGACCAAA CTGGCCAAGG ATATCTGTGC CGACCCCAAG AAGAAGTGGG TGCAGGATTC CATGAAGTAT CTGGACCAAA AATCTCCAAC TCCAAAGCCA TAAATAATCA CCATITGA AACCAAACCA GAGCCTGAGT GTTGCCTAAT TTGTTCCC TrCTTACAAT GCATTCTGAG GTAACCTCAT TATCAGTCCA AAGGGCATGG GTTATTAT ATATATATAT ATATA-ITIT TTTAAAAAA AAACGTATrG CATTAAM ATTGAGGCTT TAAAACTrAT CCTCCATGAA TATCAGTrAT TTTTAAACTG TAAAGCTG TGCAGATTCT TTACCCCCTG GGAGCCCCAA TrCGATCCCC TGTCACGTGT GGGCAATGTT CCCCCTCTCC TCTCTTCCTC CCTGGAATCT TGTAAAGGTC CTGGCAAAGA TGATCAGTAT GAAAATGTCA TTGTTCTTGT GAACCCAAAG TGTGACTCAT TAAATGGAAG TAATGTTGTT TrAGGAATAC ATAAAGTATG TGCATAT-11 ATTATAGTCA CTAGTrGTAA TITITGTG GGAAATCCAC ACTGAGCTGA GGGGG-3- (FRAG. NO: _(SEQ. ID NO:2494) 5'-GCA'ITITC AAGTTATG ATFTATTrAA CTTGTGGAAC AAAAATAAAC CAGAAACCAC CACCTCTCAC GCCAAAGCTC ACACCTTCAG CCTCCAACAT GAAGGTCTCC GCAGCACTIC TGTGGCTGCT GCTCATAGCA GCTGCCTrCA GCCCCCAGGG GCTCGCTGGG CCAGCTTCTG TCCCAACCAC CTGCTGCTTT AACCTGGCCA ATAGGAAGAT ACCCCITTCAG CGACTAGAGA GCTACAGGAG AATCACCAGT GGCAAATGTC CCCAGAAAGC TGTGATCTrC AAGACCAAAC TGGCCAAGGA TATCTGTGCC GACCCCAAGA AGAAGTGGGT GCAGGATTCC ATGAAGTATC TGGACCAAAA ATCTCCAACT CCAAAGCCAT AAATAATCAC CATmTGAA ACCAAACCAG AGCCTGAGTG TrGCCTAATT TGTITCCCT TCTACAATG CATTCTGAGG TAACCTCATT ATCAGTCCAA AGGGCATGGG T11ATTATA TATATATATA TITITIT AAAAAAAAAC GTATTGCATT TAATTTATrG AGGCTAAA ACTTATCCTC CATGAATATC AGTrATIT11 AAACrGTAAA GCTGTGCA GATTCTTTAC CCCCTGGGAG CCCCAATTCG ATCCCCTGTC ACGTGTGGGC AATGTrCCCC CTCTCCTCTC TTCCTCCCTG GAATCTTGTA AAGGTCCTGG CAAAGATGAT CAGTATGAAA ATGTCATTGT TCTTGTGAAC CCAAAGTGTG ACTCATTAAA TGGAAGTAAA TGTTGTTA GGAATAC-3' (FRAG.NO:_)(SEQ. ID NO:2491) 5'-ATGAAGGTCT CCGCAGCACT TCTGTGGCTG CTGCTCATAG CAGCTGCCTT CAGCCCCCAG GGGCTCGCTG GGCCAGCTTC TGTCCCAACC ACCTGCTGCT TTAACCTGGC CAATAGGAAG ATACCCCTTC AGCGACTAGA GAGCTACAGG AGAATCACCA GTGGCAAATG TCCCCAGAAA GCTGTGATCT TCAAGACCAA ACTGGCCAAG GATATCTGTG CCGACCCCAA GAAGAAGTGG GTGCAGGATT CCATGAAGTA TCTGGACCAA AAATCTCCAA CTCCAAAGCC ATAA-3' (FRAG. NO: )(SEQ. ID NO:2492) 5'-CCACATATTC CCCTCC=ITT CCAAGGCAAG ATCCAGATGG ATTAAAAAAT GTACCAAGTC CCTCCTACTA GCTTGCCTCT CTTCTGTTCT GCTTGACTTC CTAGGATCTG GAATCTGGTC AGCAATCAGG AATCCCTrCA TCGTGACCCC CGCATGGGCA AAGGCTrCCC TGGAATCTCC CACACTGTCT GCTCCCTATA AAAGGCAGGC AGATGGGCCA GAGGAGCAGA GAGGCTGAGA CCAACCCAGA AACCACCACC TCTCACGCCA AAGCTCACAC CTTCAGCCTC CAACATGAAG GTCTCCGCAG CACTTCTGTG GCTGCTGCTC ATAGCAGCTG CCTTCAGCCC CCAGGGGCTC GCTGGGCCAG GTAAGCCCCC CAACTCCTTA CAGGAAAGGT AAGGTAACCA CCTCCAGGCT ACTAGGTCAG CAAGAATCT TACAGACTCA CTGCAAATrC TCCATTGAA AAATAGGGAA ACAGGTTTG TGGGTGGACA AGAAATGCCT CAACCGTCAC ATCCAGTCAC TGGAAGAGCC AGAACTAGAA AGCTCCCGAG TCITITCCCC ACATTCAAGA GGGCCGCTGG GTGCATCCTT ACCCAGCTAT CCTTACAGTG TTTGGGAATG GGGAATGGCT CTGTCTTfACT GTGGGCATGG TGGGCATTTT TGGCAGTGGG AGAGAAGGAA AATCTGTTGA TrAGAAGcTC AGTATGTrAA TrCGACTCCA GGACAGCTTT CAGAGACAGT GGCTAAGAGA AGAACGAGGT CCCAGGGGAT c7CTGAGGT GACTFATTT GACACTCTTT GGGAAAGTTA TCTAGGAGAT TTGTrCCATA ACTCATTfC CCATACTCTG GTGACAAATT TACTGAGTGT ATCGGTCCCA CTGAGCCAGT GCATAGCATG GTAACAAACA GTTCTAAATT ATCAATGACT TAACAGAATT AACTAAATTA ACAAAAGTTA CTTTCTCACT TGTACTAAAT ATCTATAATG TATGGGCTCA GGCT7CTGCA TITATACTC AGGATTCTAG ACTGATGGAG AAGTrGCCAT GTGGGGGAAC ATrGATGGAT ACTGTGATAA AGCAGAAGAA AGCTCTCAGG AGTCTTGCAT AGGCAATGCA CTGTGGCTCA AAAATGACAC CCATCACTTT GTCTCCTrCT TTATTGATCA AAACTAATTA ATGCCTCCAA CCAAACAAAA GTGGCCAAGA AATGCAAGTC TACCTTGTGT CTCAAAACAG AGGATGGAGA ATA'TTGGTG AAAATACCA TGACCATCAC ATGGCCACGT AGGTCTITAT AATGACAGAG CTAGCATTG TCACATTGAC CAAGC=TGT CCATACACTC TACAGTAATG ATGAGTCCTC AGTGCACAGG GGAGGATGCT GAAGACACAG GACAGCATCC TCCAGACACA TAAGACTTCA GAGCAGAGGG ATTCTCCCTC CACCTCTCGC AATTCCITGC TTTCTCCTAA CTCCTTTAC AAAGTCATGC TTGGAAATGT CTATGTATCA TCATGTGGCT CATITITITC TCTGTTCATT TITITCCCC AAAATrCAGC 1TCTGTCCCA ACCACCTGCT GCTAACCT GGCCAATAGG AAGATACCCC T7CAGCGACT AGAGAGCTAC AGGAGAATCA CCAGTGGCAA ATGTCCCCAG AAAGCTGTGA TGTAAGTAAA TAAAGTTCAC CCTCCCCTAG ACAAAAAAAT AATGTCTAGG GCACAGAGTC AAGAACTGTG GGAGTCATAG ACTCTGATAG ITTGACCTCT ATGGTCCAAT TCATrAATTT TCACAAGTGA GTGTrCACTC CCAGCTCCCT GCCTGGGAGA TrGCTGTAGT CATATCAA'T TCTTCAAGTC AAGAGCAAAG ATGGTAC TGGGCCTA AGAGCAGCAA CTAACCCAAG AGTCTCATCC TTCCTCCTCT CCGTAGCAAC CC=TGTCCA GGGGCAGATG GTCCrTAAAT ATITAGGGTC AAATGGGCAG AATTTTCAAA AACAATCCTT CCAATTGCAT CCTGATTCTC CCCACAGCTT CAAGACCAAA CTGGCCAAGG ATATCTGTGC CGACCCCAAG AAGAAGTGGG TGCAGGATTC CATGAAGTAT CTGGACCAAA AATCTCCAAC TCCAAAGCCA TAAATAATCA CCATITTTGA AACCAAACCA GAGCCTGAGT GTTGCCTAAT TTGTTTTCCC TTCTTACAAT GCATTCTGAG GTAACCTCAT TATCAGTCCA AAGGGCATGG GTTATTAT ATATATATAT ATATATITI TTAAAAAA AAACGTATrG CATTAATIT ATTGAGGCTT TAAAACITAT CCTCCATGAA TATCAGTTAT TTITAAACTG TAAAGCTTTG TGCAGATTCT TTACCCCCTG GGAGCCCCAA TTCGATCCCC TGTCACGTGT GGGCAATGTT CCCCCTCTCC TCTCTTCCTC CCTGGAATCT TGTAAAGGTC CTGGCAAAGA TGATCAGTAT GAAAATGTCA TTGTTCTrGT GAACCCAAAG TGTGACTCAT TAAATGGAAG TAATGTrGTr TrAGGAATAC ATAAAGTATG TGCATATTIT ATIATAGTCA CTAGTrGTAA TfITITTGTG GGAAATCCAC ACTGAGCTGA GGGGG-3' (FRAG. NO:_)(SEQ. ID NO:2493) FK-506 Binding Protein Nucleic Acids and Oligonucleotide Fragments 5'- GCCAGGTCGC TGTrGGTCCA CGCCGCCCGT CGCGCCGCCC GCCCGCTCAG CGTCCGCCGC CGCCATGGGA GGCCGGAGCC GAGCCGGGGT CGGGCAGCAG CAGGGACCCC CCAGAGGCGG GGCCTGTGGG ACCGCTATGG GCGTGGAGAT CGAGACCATC TCCCCCGGAG ACGGAAGGAC ATTCCCCAAG AAGGGCCAAA CGTGTGTGGT GCACTACACA GGAATGCTCC AAAATGGGAA GAAGTTTGAT TCATCCAGAG ACAGAAACAA ACCTTCAAG TTCAGAATrG GCAAACAGGA AGTCATCAAA GGTTITGAAG AGGGTGCAGC CCAGATGAGC TTGGGGCAGA GGGCGAAGCT GACCTGCACC CCTGATGTGG CATATGGAGC CACGGGCCAC CCCGGTGTCA TCCCTCCCAA TGCCACCCTC ATCTTTGACG TGGAGCTGCT CAACTTAGAG TGAAGGCAGG AAGGAACTCA AGGTGGCTGG AGATGGCTGC TGCTCACCCT CCTAGCCTGC TCTGCCACTG GGACGGCTCC TGCITTGGG GCTCTTGATC AGTGTGCrAA CCTCACTGCC TCATGGCATC ATCCATTCTC TCTGCCCAAG TTGCTCTGTA TGTGTTCGTC WO 00/09525 PCTIUS99/1 7712 EPI-109 250 AGTGT'rCATG CGAATTCTTG CFGAGGAAA C'PTCGGTTGC AGAT7GAAGC A7CAGGrr GTGCA'ITG TGTGATGCAT GTAGTAGCCT TrCCTGATGA CAGAACACAG ATCr=Grr CGCACAATCT ACACTGCCTT ACCTrCACTT AAACCACACA CACAAGGTGC TCAGACATGA AATGTACATG GCGTACCGTA CACAGAGGGA CTGAGCCAG TrACCTIGC TGTCACC TCTCTTATAA ArrCTG~rAG CIrGCJTCACT[ AAACAATGTC CTC1TGAGA AAATGTAAAA TAAAGGCTCT GTGCTI1GACA GAATTCGGGC CGCCGCCAGG TCGCTGTlGG TCCACGCCGC CCGTCGCGCC GCCCGCCCGC TCAGCGTCCG CCGCCGCCAT GGGAGTGCAG GTGGAAACCA TCTCCCCAGG AGACGGGCGC ACC=CCCCA AGCGCGGCCA GACCTGCGTG GTGCACTACA CCGGGATGCT TGAAGATGGA AAGAAA 1TG ATTCCrCCCG GGACAGAAAC AAGCCC1TA AGTIATGCT AGGCAAGCAG GAGGTGATCC GAGGCTGGGA AGAAGGGGYT GCCCAGATGA GTGTGGGTCA GAGAGCCAAA CTGACrATAT CTCCAGATTA TGCCTATGGT GCCACTGGGC ACCCAGGCAT CATCCCACCA CATGCCACTC TCGTC'ICGA TGTGGAGcIT CTAAAACrGG AATGACAGGA ATGGCCTCCr CCMIAGCTC CCT7GTrCTTG GATCTGCCAT GGAGGGATCT GGTGCCTCCA GACATGTGCA CATGAGTCCA TATGGAGCT7T FCCTGATGT TCCACTCCAC 1TGTATAGA CATCTGCCCT GACTGAATGT GT~TGTCAC TCAGCTIGC TTCCGACACC TCTGTICCT CTTCCCC=h CTCCTrCGTAT GTGTGTIAC CTAAACTATA TGCCATAAAC CTCAAGTTAT TCATI1ATI' TrG FTCAT TT]TGGGGTGA AGATrCAGTr TCAGTCT1T GGATATAGGT T~rCCAAT~rAA GTACATGGTC AAGTATTAAC AGCACAAGTG GTAGGTTAAC AflAGAATAG GAA'ITGGTGT TGGGGGGGGG GTT7GCAAGA ATA'F=ATr T]7AAM=IT GGATGAAATF 'Tr7ATCTATr ATATAT7AAA CATrCTrGCT GCTGCGCTGC AAAGCCATAG CAGATTGAG GCGCTGT7GA GGACTGAATT ACrCTCCAAG TFGAGAGATG TCTTGGGT7 AAAT7AAAAG CCCTACCTAA AACTGAGGTG GGGATGGGGA GAGCCITGC CTCCACCA~r CCCACCCACC CTCCCCTrAA ACCCTCTGCC ITTGAAAGTA GATCATGTTC ACTGCAATGC TGGACACTAC AGGTATCTGT CCCTGGGCCA GCAGGGACCT CTGAAGCCTr CTPGTGGCC 1TFrT]T T7CATCCTGT GGTITTCTA ATGGACI=C AGGAAFFIG TAATCTCATA AC=rCCAAG CTCCACCACT TCCTAAATCT TAAGAAC1T AATrGACAGT TrCAATrGAA GGTGCTGTI GTAGACTTAA CACCCAGTGA AAGCCCAGCC ATCATGACAA ATC=TGAAT GT7CTCT-FAA GAAAATGATG CTGGTCATCG CAG=rCAGC ATCrCCrrTT GATGCT TGGCTCCCTC TGCTGATCTrC AGMFCCTGG CT1TCCTCC CTCAGCCCCT TCTCACCCCT TFrGCTGTCCT GTGTAGTGAT T'rGGTGAGAA ATCGTrGCTG CACCCTCCC CCAGCACCAT TTATGAGTCT CAAGTII1AT TATTGCAATA AAAGTGCMr ATGCCCGAAT TC GCCGCCGCCA TGGGAGTGCA GGTGGAAACC AT~TCCCCAG GAGACGGGCG CAC=TCCCC AAGCGCGGCC AGACCTGCGT GGTGCACTAC ACCGGGATGC 'ITGAAGATGG AAAGAAA'T GAT7CCICCC GGGACAGAAA CAAGCCC=r AAGT7ATGC TAGGCAAGCA GGAGGTGATC CGAGGCTGGG AAGAAGGGGT TGCCCAGATG AGTGTGGGTC AGAGAGCCAA ACTGACTATA TCTCCAGATF ATGCCTATGG TGCCACTGGG CACCCAGGCA TCATCCCACC ACATGCCACT CTrCGTCITCG ATGTGGAGCT TCTAAAACTG GAATGACAGG AATGGCCTCC TCCCTTAGCT CCV1TG'TCTT GGATCTGCCR TGGAGGGATC TGGTGCCTCC AGACATGTGC ACATGARTCC ATATGGAGCT 'FMCCTGATG 7rCCACTCCA CrrGTATAG ACATCTGCCC TGACrGAATG TGTrCTGTCA CrCAGCI=G CTrCCGACAC CTCTGM~CC TCTCCCC'IT TCTCCTCGTA TGTGTG'IMA CCTAAACTAT ATGCCATAAA CCTCAAGTTA TrCA-3' (FRAG. NO:J(SEQ. ID NO:2499) 5'-GCCAGGTCGC TGTT'GGTCCA CGCCGCCCGT CGCGCCGCCC GCCCGCTFCAG CGTCCGCCGC CGCCATGGGA-3' (FRAG. No:_)(SEQ. ID NO: 2495) S'-GGCCGGAGCC GAGCCGGGGT CGGGCAGCAG CAGGGACCCC CCAGAGGCGG GGCCTGTGGG ACCGCTATGG GCGTGGAGAT CGAGACCATC TCCCCCGGAG ACGGAAGGAC AT7CCCCAAG AAGGGCCAAA CGTGTGTGGT GCACTACACA GGAATGCTCC AAAATGGGAA GAAGT'17GAT TCATCCAGAG ACAGAAACAA AC=hTCAAG 717CAGAATTG GCAAACAGGA AGTCATCAAA GGT1TGAAG AGGGTGCAGC CCAGATGAGC T7GGGGCAGA GGGCGAAGCT GACCTGCACC CCTGATGTGG CATATGGAGC CACGGGCCAC CCCGGTGTCA TCCCTCCCAA TGCCACCCTC ATC'=GACG TGGAGCTGCT CAA=TAGAG TGAAGGCAGG AAGGAACTCA AGGTGGCTGG AGATGGCTGC TGCTCACCCT CCTAGCCTGC TCTGCCACTG GGACGGCTCC TGCI I IGGG GCTCITGATC AGTGTGCTAA CCTCACTGCC TCATGGCATC ATCCATrCTC TCTGCCCAAG 17GCTCTGTA TGTGTTCGTC AGTGT7CATG CGAATTG CT7GAGGAAA C'FrCGG717GC AGAFI7GAAGC AIT]7CAGGTF7 GTGCA=IIG TGTGATGCAT GTAGTAGCCT TTCCTGATGA CAGAACACAG ATCTCIGTr CGCACAATCT ACACTGCCT7 ACCTFCACT7 AAACCACACA CACAAGGTGC TCAGACATGA AATGTACATG GCGTACCGTA CACAGAGGGA CTIGAGCCAG 'FFACCTTrGC TGTCACTI7rC TCT=~ATAA A'17CTGT7AG CTGCTCACT AAACAATGTC CTCIIGAGA AAATGTAAAA TAAAGGCTCT GTG=TGACA-3' (FRAG. NO:_) (SEQ. ID NO:2496) 5'-GAATflCGGGC CGCCGCCAGG TCGCTGT-rGG TCCACGCCGC CCGTCGCGCC GCCCGCCCGC TCAGCGTCCG CCGCCGCCAT GGGAGTGCAG GTGGAAACCA TCTCCCCAGG AGACGGGCGC ACCMCCCCA AGCGCGGCCA GACCTGCGTG GTGCACTACA CCGGGATGCT TGAAGATGGA AAGAAA'ITG ATTCCTCCCG GGACAGAAAC AAGCCCITA AGTITATGCT AGGCAAGCAG GAGGTGATCC GAGGCTGGGA AGAAGGGGrr GCCCAGATGA GTGTGGGTCA GAGAGCCAAA CTGACTATAT CTCCAGATrA TGCCTATGGT GCCACTGGGC ACCCAGGCAT CATCCCACCA CATGCCACTC TCGTCTTCGA TGTGGAGCTT CTAAAACTrGG AATGACAGGA ATGGCCTCCT CC=TAGCTC CCTGTrClTG GATCTGCCAT GGAGGGATCT GGTGCCTCCA GACATGTGCA CATGAGTCCA TATGGAGCI TI'CCTGATGT TCCACTCCAC TIT7GTATAGA CATCTGCCCT GACTGAATGT GTrCTGTCAC TCAGC=rGC TTCCGACACC TCTGTFrCCT =ICCCC=I CTCCTCGTAT GTGTGM~AC CTAAACTATA TGCCATAAAC CTCAAGT7AT TCATITA'r ~GTICAT =TGGGGTGA AGATrCAGTr TCAGTCTIT GGATATAGGT TrCCAATrAA GTACATGGTC AAGTATTAAC AGCACAAGTG GTAGGTrAAC AT7AGAATAG GAATrGGTGT TGGGGGGGGG GM~GCAAGA ATATIIAT7 TrAA GGATGAAAT7 1TrATCTATr ATATATTAAA CAT~TI7GCT GCTGCGCTGC AAAGCCATAG CAGA TTGAG GCGCTGTTGA GGACTGAATIT ACTCTCCAAG FIGAGAGATG TCF=GGGTF AAATTAAAAG CCCTACCTAA AACTGAGGTG GGGATGGGGA GAGCC'=GC CTCCACCATT CCCACCCACC CTCCCCTTAA ACCCTCTGCC T ITGAAAGTA GATCATG~rC ACTGCAATGC TGGACACTAC AGGTATCTGT CCCTGGGCCA GCAGGGACCT CTGAAGCCT7 ='~GTGGCC I 11 1 1 1 = 7TCATCCTGT GGTIT=CTA ATGGACTTC AGGAATITG TAATCrCATA AC1TCCAAG CTCCACCACT TCCTAAATCT TAAGAACIT AATTGACAGT Y17CAAflGAA GGTGCTGTF17 GTAGAC~rAA CACCCAGTGA AAGCCCAGCC ATCATGACAA ATC=TGAAT G'rTCTCTTAA GAAAATGATG CTGGTCATCG CAGCTCAGC ATCTCCTGTT TITGATGCT TGGCTCCCTC TGCTGATCrC AGMrCCTGG CTrCCrCC CTCAGCCCCT TCTCACCCCT TGCTGTCCT GTGTAGTGAT FrGGTGAGAA ATCGT7GCTG CACCCTTCCC CCAGCACCAT TTATGAGTCT CAAGTITAT TATIGCAATA AAAGTGCI= ATGCCCGAAT TC-3' (FRAG. NO:_)(SEQ. ID NO:2497) 5' GCCGCCGCCA TGGGAGTGCA GGTGGAAACC ATCTCCCCAG GAGACGGGCG CACCICCCC AAGCGCGGCC AGACCTGCGT GGTGCACTAC ACCGGGATGC TTGAAGATGG AAAGAAATT7 GAT7CCTCCC GGGACAGAAA CAAGCCCT= AAGTIATGC TAGGCAAGCA GGAGGTGATC CGAGGCTGGG AAGAAGGGGT TGCCCAGATG AGTGTGGGTC AGAGAGCCAA ACTGACTATA TCTCCAGA'Fr ATGCCTATGG TGCCACTGGG CACCCAGGCA TCATCCCACC ACATGCCACT CTCGTCTI'CG WO 00/09525 PCT/US99/17712 EPI-109 251 ATGTGGAGCT TCTAAAACTG GAATGACAGG AATGGCCTCC TCCCTTAGCT CCCTGTTCTT GGATCTGCCR TGGAGGGATC TGGTGCCTCC AGACATGTGC ACATGARTCC ATATGGAGCT TTCCTGATG TTCCACTCCA CTTTGTATAG ACATCTGCCC TGACTGAATG TGTTCTGTCA CTCAGCTG CTTCCGACAC CTCTGTTTCC TCTTCCCCTT TCTCCTCGTA TGTGTGTTTA CCTAAACTAT ATGCCATAAA CCTCAAGTTA TrCA-3' (FRAG. NO:_)(SEQ. ID NO:2498) The present agents are also provided as a pharmaceutical composition comprising an anti-sense oligonucleotide as given above in an amount effective to reduce expression of a target mRNA, by passing through a cell membrane and binding specifically with target mRNA in the cell so as to prevent its translation are another aspect of the present invention. Such compositions are provided in a suitable pharmaceutically acceptable carrier, e.g. sterile pyrogen-free saline solution. The agent of the invention may be formulated with a hydrophobic carrier capable of passing through a cell membrane, e.g. in a liposome, with the liposomes carried in a pharmaceutically acceptable aqueous carrier. The oligonucleotides may be coupled to an agent which inactivates mRNA, such as a ribozyme. Such oligonucleotides may be administered to a subject in need of such treatment to inhibit the activation of A, A 2 b and/or A, adenosine receptors. The pharmaceutical formulation may also comprise chimeric molecules comprising anti-sense oligonucleotides attached to molecules which are known to be internalized by cells. These oligonucleotide conjugates utilize cellular up-take pathways to increase intracellular concentrations of the oligonucleotide. Examples of molecules used in this manner are macromolecules including transferrin, asialoglycoprotein (bound to oligonucleotides via polylysine) and streptavidin, among others. The anti-sense compound may be contained in the pharmaceutical formulation within a lipid particle or vesicle, such as a liposome or microcrystal. The particles may be of any suitable structure, such as unilamellar or plurilamellar. The one preferred embodiment, the anti-sense oligonucleotide is comprised within the liposome. Positively charged lipids such as N-[l-(2, 3 -dioleoyloxi) propyl] -N, N, N-trimethylammoniumethylsulfate, or "DOTAP", are particularly preferred for such particles and vesicles. However, others are also suitable. The preparation of such lipid particles is well known. See, e.g., US Patent Nos. 4,880,635 to Janoff et al., 4,906,477 to Kurono et al., 4,911,928 to Wallach, 4,917,951 to Wallach, 4,920,016 to Allen et al., 4,921,757 to Wheatley et al., the relevant sections of all of which are herein incoporated in their entireties by reference. The composition of the invention may be administered by any means which transports the agent to the lung(s). The present agent(s) may be administered to the lungs of a patient by any suitable means, but are preferably administered through the respiratory system as a respirable formulation, more preferably in the form of an aerosol comprising respirable particles which, in turn, comprise the agent for respiration or inhalation by the subject. The respirable particles may be in gaseous, liquid or solid form, and they may, optionally, contain other therapeutic ingredients and formulation components. The particles of the present invention are preferably particles of respirable size, preferably of a size sufficiently small to pass, upon inhalation, through the mouth and larynx and into the bronchi and alveoli of the lungs. In general, particles ranging from about 0.5 to 10 microns in diameter are respirable. However, other sizes may also be suitable. Particles of non-respirable size, of considerably larger diameter, which are included in the respirable formulation tend to deposit in the throat and may be swallowed. Accordingly, it is desirable to minimize the quantity of non-respirable particles in the aerosol. For nasal administration, a particle size in the range of 10-500 :m is preferred to ensure their retention in the nasal cavity. Liquid pharmaceutical compositions of the agent of the invention for producing a respirable formulation, e.g. an aerosol may be prepared by combining the anti-sense oligo with a suitable vehicle or carrier, such as sterile pyrogen-free water and/or other known pharmaceutically or veterinarily acceptable carrier. Other therapeutic compounds may be included as well as other formulation ingredients as is known in the art. Solid particulate compositions comprising respirable dry particles of, e.g. the micronized agent of the invention may be prepared by grinding the dry anti-sense compound with a mortar and pestle, and then passing the thus ground, e.g. micronized composition through a screen, e.g. 400 mesh screen, to break up or separate large agglomerates of particles. A solid particulate composition comprising the anti-sense compound may optionally also comprise a dispersant and other known agents, which serve to facilitate the formation of a mist or aerosol. A suitable dispersant is lactose, which may be blended with the anti-sense compound in 'any suitable ratio, about 1:1 w/w. Other ratios may be utilized as well, and other therapeutic and formulation agents may also be included. The dosage of the anti-sense compound administered generally varies with the disease being treated, the condition of the subject, the particular formulation, the route of administration, the timing of administration to a subject, etc. In general, it is desirable to attain intracellular concentrations of the oligonucleotide of from 0.05 to 50 :M, or more particularly 0.2 to 5 :M, although not critical. For administration to a subject such as a human, a dosage of from about .01, preferably about 0.01, more preferably about 1 mg/Kg, to about 150, preferably about WO 00/09525 PCT/US99/17712 EPI-109 252 100, and still more preferably about 50 mg/Kg are typically employed. Higher and lower doses may also be administered as an artisan will see suitable for specific application. These amounts are preferably administered every 24 hrs, although other regimens are also suitable. Depending on the solubility of the particular formulation of active compound administered, a daily dose may be divided among one or several unit dose administrations. Administration of the anti-sense compounds may be carried out therapeutically, i.e. as a rescue treatment, prophylactically, or as a chronic maintenance regimen. Aerosols of liquid particles comprising the agent may be produced by any suitable means, such as with an insufflator or nebulizer. See, e.g., US Patent No. 4,501,729. Nebulizers are commercially available devices which transform solutions or suspensions of an agent into a therapeutic aerosol mist either by means of acceleration of a compressed gas, typically air or oxygen, e.g. through a narrow venturi orifice or by means of ultrasonic agitation. Suitable formulations for use in insufflators and nebulizers comprise the present agent, the agent of this invention, in an amount of about 0.01 to about 40%, preferably less than 20% w/w in a liquid carrier which is typically water or a dilute aqueous alcoholic solution, preferably made isotonic with body fluids by the addition of, for example, sodium chloride. Other carriers are also suitable. Optional additives include preservatives if the formulation is not prepared sterile, for example, methyl hydroxybenzoate, antioxidants, flavoring agents, volatile oils, buffering agents and surfactants, among others. The pharmaceutical compositions provided herein comprise nucleic acid(s) comprising the anti-sense oligonucleotide(s) described above and one or more surfactants. Suitable surfactants or surfactant components for enhancing the uptake of the anti-sense oligonucleotides of the invention include synthetic and natural as well as full and truncated forms of surfactant protein A, surfactant protein B, surfactant protein C, surfactant protein D and surfactant Protein E, di-saturated phosphatidylcholine (other than dipalmitoyl), dipalmitoylphosphatidylcholine, phosphatidylcholine, phosphatidylglycerol, phosphatidylinositol, phosphatidylethanolamine, phosphatidylserine; phosphatidic acid, ubiquinones, lysophosphatidylethanolamine, lysophosphatidylcholine, pahitoyl-lysophosphatidylcholine, dehydroepiandrosterone, dolichols, sulfatidic acid, glycerol-3-phosphate, dihydroxyacetone phosphate, glycerol, glycero-3-phosphocholine, dihydroxyacetone, palmitate, cytidine diphosphate (CDP) diacylglycerol, CDP choline, choline, choline phosphate; as well as natural and artificial lamelar bodies which are the natural carrier vehicles for the components of surfactant, omega-3 fatty acids, polyenic acid, polyenoic acid, lecithin, palmitinic acid, non-ionic block copolymers of ethylene or propylene oxides, polyoxypropylene, monomeric and polymeric, polyoxyethylene, monomeric and polymeric, poly (vinyl amine) with dextran and/or alkanoyl side chains, Brij 35, Triton X-100 and synthetic surfactants ALEC, Exosurf, Survan and Atovaquone, among others. These surfactants may be useed either as single or part of a multiple component surfactant in a formulation, or as covalently bound additions to the 5' and/or 3' ends ofthe anti-sense oligonucleotides (oligos). The composition of the invention may be administered by any means which transports the anti-sense nucleotide and the surfactant composition to the lung. The antisense compounds disclosed herein may be administered to the lungs of a patient by any suitable means, but are preferably administered by inhalation of an aerosol comprised of respirable particles which comprise the anti-sense compound. The respirable particles may be liquid or solid, and they may optionally contain other therapeutic or diagnostic ingredients as well as other typical ingredients for a particular formulation. Examples of other agents are analgesics such as acetominophen, anilerdine, aspirin, buprenorphine, butabital, butorpphanol, Choline Salicylate, Codeine, Dezocine, Diclofenac, Diflunisal, Dihydrocodeine, Elcatoninin, Etodolac, Fenoprofen, Hydrocodone, Hydromorphone, Ibuprofen, Ketoprofen, Ketorolac, Levorphanol, Magnesium Salicylate, Meclofenamate, Mefenamic Acid, Meperidine, Methadone, Methotrimeprazine, Morphine, Nalbuphine, Naproxen, Opium, Oxycodone, Oxymorphone, Pentazocine, Phenobarbital, Propoxyphene, Salsalate, Sodium Salicylate, Tramadol and Narcotic analgesics in addition to those listed above. See, Mosby's Physician's GenRx. Anti- anxiety agents are also useful including Alprazolam, Bromazepam, Buspirone, Chlordiazepoxide, Chlormezanone, Clorazepate, Diazepam, Halazepam, Hydroxyzine, Ketaszolam, Lorazepam, Meprobamate, Oxazepam and Prazepam, among others. Anti-anxiety agents associated with mental depression, such as Chlordiazepoxide, Amitriptyline, Loxapine Maprotiline and Perphenazine, among others. Anti-inflammatory agents such as non-rheumatic Aspirin, Choline Salicylate, Diclofenac, Diflunisal, Etodolac, Fenoprofen, Floctafenine, Flurbiprofen, Ibuprofen, Indomethacin, Ketoprofen, Magnesium Salicylate, Meclofenamate, Mefenamic Acid, Nabumetone, Naproxen, Oxaprozin, Phenylbutazone, Piroxicam, Salsalate, Sodium Salicylate, Sulindac. Tenoxicam, Tiaprofenic Acid, Tolmetin, anti-inflammatories for WO 00/09525 PCT/US99/17712 EPI-109 253 ocular treatment such as Diclofenac, Flurbiprofen, Indomethacin, Ketorolac, Rimexolone (generally for post operative treatment), anti-inflammatories for, non-infectious nasal applications such as Beclomethaxone, Budesonide, Dexamethasone. Flunisolide, Triamcinolone, and the like. Soporifics (anti-insomnia/sleep inducing agents) such as those utilized for treatment of insomnia, including Alprazolam, Bromazepam, Diazepam, Diphenhydramine, Doxylamine, Estazolam, Flurazepam, Halazepam, Ketazolam, Lorazepam, Nitrazepam, Prazepam Quazepam, Temazepam, Triazolam, Zolpidem and Sopiclone, among others. Sedatives including Diphenhydramine, Hydroxyzine, Methotrimeprazine, Promethazine, Propofol, Melatonin, Trimeprazine, and the like. Sedatives and agents used for treatment of petit mal and tremors, among other conditions, such as Amitriptyline HCl; Chlordiazepoxide, Amobarbital; Secobarbital, Aprobarbital, Butabarbital, Ethchiorvynol, Glutethimide, L-Tryptophan, Mephobarbital, MethoHexital Na, Midazolam Hcl, Oxazepam, Pentobarbital Na, Phenobarbital, Secobarbital Na, Thiamylal Na, and many others. Agents used in the treatment of head trauma (Brain Injury/Ischemia), such as Enadoline HCl (e.g. for treatment of severe head injury; orphan status, Warner Lambert), cytoprotective agents, and agents for the treatment of menopause, menopausal symptoms (treatment), e.g. Ergotamine, Belladonna Alkaloids and Phenobarbital, for the treatment of menopausal vasomotor symptoms, e.g. Clonidine, Conjugated Estrogens and Medroxyprogesterone, Estradiol, Estradiol Cypionate, Estradiol Valerate, Estrogens, conjugated Estrogens, esterified Estrone, Estropipate, and Ethinyl Estradiol. Examples of agents for treatment of pre menstrual syndrome (PMS) are Progesterone, Progestin, Gonadotrophic Releasing Hormone, Oral contraceptives, Danazol, Luprolide Acetate, Vitamin B6. Examples of agents for treatment of emotional/psychiatric treatments such as Tricyclic Antidepressants, including Amitriptyline HCl (Elavil), Amitriptyline HCl, Perphenazine (Triavil) and Doxepin HCI (Sinequan). Examples of tranquilizers, anti depressants and anti-anxiety agents are Diazepam (Valium), Lorazepam (Ativan), Alprazolam (Xanax), SSRI's (selective Ssrotonin reuptake inhibitors), Fluoxetine HCI (Prozac), Sertaline HCl (Zoloft), Paroxetine HCI (Paxil), Fluvoxamine Maleate (Luvox), Venlafaxine HCl (Effexor), Serotonin, Serotonin Agonists (Fenfluramine), and other over the counter (OTC) medications. The composition of the present invention may be administered into the respiratory system as a formulation including particles of respirable size, e.g. particles of a size sufficiently small to pass through the nose, mouth and larynx upon inhalation and through the bronchi and alveoli of the lungs. In general, respirable particles range from about .5 to 10 microns in size. Particles of non-respirable size which are included in the aerosol tend to deposit in the throat and be swallowed, and the quantity of non-respirable particles in the aerosol is thus minimized. For nasal administration, a particle size in the range of 10-500 :m is preferred to ensure retention in the nasal cavity. Aerosols or mists of solid particles comprising the agent of the invention may likewise be produced with any device that generates solid particulate medicament aerosols or mists. Aerosol and mist generators are suitable for administering solid particulate medicaments. These devices produce respirable particles, as explained above., and generate a volume of aerosol or mist containing a predetermined metered dose of a medicament at a rate suitable for human or animal administration. One illustrative type of solid particulate aerosol generator is an insufflator. Suitable formulations for administration by insufflation include finely comminuted powders which may be delivered by means of an insufflator or taken into the nasal cavity in the manner of a snuff. In the insufflator, the powder, e.g. a metered dose of the agent effective to carry out the treatments described herein, is contained in a capsule or a cartridge. These capsules or cartridges are typically made of gelatin or plastic, and may be pierced or opened in situ, and the powder delivered by air drawn through the device upon inhalation or by means of a manually-operated pump. The powder employed in the insufflator may consist either solely of the agent or of a powder blend comprising the agent, a suitable powder diluent, such as lactose, and an optional surfactant as well as other agents. The agent typically comprises from 0.01 to 100 w/w of the formulation. A second type of illustrative aerosol generator comprises a metered dose inhaler. Metered dose inhalers are pressurized aerosol dispensers, typically comprising a suspension or solution formulation of the active ingredient in a liquified propellant. During use these devices discharge the formulation through a valve adapted to deliver a metered volume, typically about 10 to 150 :1, although other volumes are also suitable, to produce a fine particle spray containing the active ingredient. Suitable propellants include solvents such as certain chlorofluorocarbon compounds, for example, dichlorodifluoromethane, trichlorofluoromethane, dichlorotetrafluoroethane and/or mixtures thereof. The formulation may additionally comprise one or more co-solvents, for example, ethanol, surfactants, such as oleic acid or sorbitan trioleate, antioxidants and suitable flavoring agents. The aerosol, whether formed from solid or liquid particles, may be produced by the aerosol generator at a rate of from about 10 to 150 liters per minute, more preferably from about WO 00/09525 PCT/US99/17712 EPI-109 254 30 to 150 liters per minute, and most preferably about 60 liters per minute. Aerosols containing greater amounts of medicament may be administered more rapidly. The following examples are provided to illustrate the present invention, and should not be construed as limiting thereon. In these examples, :M means micromolar, ml means milliliters, :M means micrometers, mm means millimeters, cm means centimeters, EC means degrees Celsius, :g means micrograms, mg means milligrams, g means grams, kg means kilograms, M means molar, and h means hours. EXAMPLES Example 1: Design and Synthesis of Anti-sense Oligonucleotides The design of anti-sense oligonucleotides against the A, and A, adenosine receptors may require the solution of the complex secondary structure of the target A, receptor mRNA and the target A, receptor mRNA. After generating this structure, anti-sense nucleotide are designed which target regions of mRNA which might be construed to confer functional activity or stability to the mRNA and which optimally may overlap the initiation codon. Other target sites are readily usable. As a demonstration of specificity of the anti-sense effect, other oligonucleotides not totally complementary to the target mRNA, but containing identical nucleotide compositions on a w/w basis, are included as controls in anti-sense experiments. The mRNA secondary structure of the adenosine A, receptor was analyzed and used as described above. to design a phosphorothioate anti-sense oligonucleotide. The anti-sense oligonucleotide which was synthesized was designated HAdAAS and had the following sequence: 5' -GAT GGA GGG CGG CAT GGC GGG-3' ( SEQ ID NO:1). As a control, a mismatched phosphorothioate anti-sense nucleotide designated HAdAlMMl was synthesized with the following sequence: 5' -GTA GCA GGC GGG GAT GGG GGC-3' (SEQ ID NO:2). Each oligonucleotide had identical base content and general sequence structure. Homology searches in GENBANK (release 85.0) and EMBL (release 40.0) indicated that the anti-sense oligonucleotide was specific for the human and rabbit adenosine A, receptor genes, and that the mismatched control was not a candidate for hybridization with any known gene sequence. The secondary structure of the adenosine A, receptor mRNA was similarly analyzed and used as described above to design two phosphorothioate anti-sense oligonucleotides. The first anti-sense oligonucleotide (HAdA3AS1) synthesized had the following sequence: 5'-GTT GTT GGG CAT CTT GCC-3' (SEQ ID NO:3). As a control, a mismatched phosphorothioate anti-sense oligonucleotide (HAdA3MM1) was synthesized, having the following sequence: 5'-GTA CTT GCG GAT CTA GGC-3' (SEQ ID NO:4). A second phosphorothioate anti-sense oligonucleotide (HAdA3AS2) was also designed and synthesized, having the following sequence: 5' GTG GGC CTA GCT CTC GCC-3' (SEQ ID NO:5). Its control oligonucleotide (HAdA3MM2) had the sequence: 5'-GTC GGG GTA CCT GTC GGC-3' (SEQ ID NO:6). Phosphorothioate oligonucleotides were synthesized on an Applied Biosystems Model 396 Oligonucleotide Synthesizer, and purified using NENSORB chromatography (DuPont, MD). Example 2: In Vivo Testing of Adenosine A, Receptor Anti-sense Oligos The anti-sense oligonucleotide against the human A, receptor (SEQ ID NO:1) described above. was tested for efficacy in an in vitro model utilizing lung adenocarcinoma cells HTB-54. HTB-54 lung adenocarcinoma cells were demonstrated to express the A, adenosine receptor using standard northern blotting procedures and receptor probes designed and synthesized in the laboratory. HTB-54 human lung adenocarcinoma cells (106/100 mm tissue culture dish) were exposed to 5.0 :M HAdAlAS or HAdAIMM1 for 24 hours, with a fresh change of media and oligonucleotides after 12 hours of incubation. Following 24 hour exposure to the oligonucleotides, cells were harvested and their RNA extracted by standard procedures. A 21-mer probe corresponding to the region of mRNA targeted by the anti-sense (and therefore having the same sequence as the anti-sense, but not phosphorothioated) was synthesized and used to probe northern blots of RNA prepared from HAdAIAS-treated, HAdAIMM 1-treated and non-treated HTB-54 cells. These blots showed clearly that HAdAlAS but not HAdAlMM1 effectively reduced human adenosine receptor mRNA by >50%. This result showed that HAdA1AS is a good candidate for an anti asthma drug since it depletes intracellular mRNA for the adenosine A, receptor, which is involved in asthma. Example 3: In Vivo Efficacy of Adenosine A, Receptor Anti-sense Oligos A fortuitous homology between the rabbit and human DNA sequences within the adenosine A, gene overlapping the initiation codon permitted the use of the phosphorothioate anti-sense oligonucleotides initially designed for use against the human adenosine A, receptor in a rabbit model. Neonatal New Zealand white Pasteurella-free rabbits were immunized intraperitoneally within 24 hours of birth with 312 antigen units/ml house dustmite (D. farinae) extract (Berkeley Biologicals, Berkeley, CA), mixed with 10% kaolin. Immunizations were WO 00/09525 PCTIUS99/17712 EPI-109 255 repeated weekly for the first month and then biweekly for the next 2 months. At 3-4 months of age, eight sensitized rabbits were anesthetized and relaxed with a mixture of ketamine hydrochloride (44 mg/kg) and acepromazine maleate (0.4 mg/kg) administered intramuscularly. The rabbits were then laid supine in a comfortable position on a small molded, padded animal board and intubated with a 4.0-mm intratracheal tube (Mallinkrodt, Inc., Glens Falls, NY). A polyethylene catheter of external diameter 2.4 mm with an attached latex balloon was passed into the esophagus and maintained at the same distance (approximately 16 cm) from the mouth throughout the experiments. The intratracheal tube was attached to a heated Fleisch pneumotachograph (size 00; DOM Medical, Richmond, VA), and flow was measured using a Validyne differential pressure transducer (Model DP-45161927; Validyne Engineering Corp., Northridge, CA) driven by a Gould carrier amplifier (Model 11-4113; Gould Electronic, Cleveland, OH). The esophageal balloon was attached to one side of the differential pressure transducer, and the outflow of the intratracheal tube was connected to the opposite side of the pressure transducer to allow recording of transpulmonary pressure. Flow was integrated to give a continuous tidal volume, and measurements of total lung resistance (RL) and dynamic compliance (Cdyn) were calculated at isovolumetric and flow zero points, respectively, using an automated respiratory analyzer (Model 6; Buxco, Sharon, CT). Animals were randomized and on Day I pretreatment values for PC50 were obtained for aerosolized adenosine. Anti-sense (HAdAIAS) or mismatched control (HAdAlMM) oligonucleotides were dissolved in sterile physiological saline at a concentration of 5000 :g (5 mg) per 1.0 ml. Animals were subsequently administered the aerosolized anti-sense or mismatch oligonucleotide via the intratracheal tube (approximately 5000 :g in a volume of 1.0 ml), twice daily for two days. Aerosols of either saline, adenosine, or anti-sense or mismatch oligonucleotides were generated by an ultrasonic nebulizer (DeVilbiss, Somerset, PA), producing aerosol droplets 80% of which were smaller than 5 :m in diameter. In the first arm of the experiment, four randomly selected allergic rabbits were administered anti-sense oligonucleotide and four the mismatched control oligonucleotide. On the morning of the third day, PC50 values (the concentration of aerosolized adenosine in mg/mi required to reduce the dynamic compliance of the bronchial airway 50% from the baseline value) were obtained and compared to PC50 values obtained for these animals prior to exposure to oligonucleotide. Following a 1 week interval, animals were crossed over, with those previously administered mismatch control oligonucleotide now administered anti-sense oligonucleotide, and those previously treated with anti-sense oligonucleotide now administered mismatch control oligonucleotide. Treatment methods and measurements were identical to those employed in the first arm of the experiment. It should be noted that in six of the eight animals treated with anti-sense oligonucleotide, adenosine-mediated bronchoconstriction could not be obtained up to the limit of solubility of adenosine, 20 mg/mI. For the purpose of calculation, PC50 values for these animals were set at 20 mg/ml. The values given therefore represent a minimum figure for anti-sense effectiveness. Actual effectiveness was higher. The results of this experiment are illustrated in Table 3 below. Table 3: Effect of Adenosine A, Receptor Anti-sense Oligo upon PC50 Values in Asthmatic Rabbits Mismatch Control A, Receptor Anti-sense Oligo Pre Oligonucleotide Post Oligonucleotide Pre Oligonucleotide Post Oligonucleotide 3.56 + 1.02 5.16 + 1.03 2.36 + 0.68 >19.5 + 0.34** The results are presented as the mean (n=8) ± SEM. The significance was determined by repeated-measures analysis of variance (ANOVA), and Tukey's protected test. **Significantly different from all other groups, p<0.01. In both arms of the experiment, animals receiving the anti-sense oligonucleotide showed an order of magnitude increase in the dose of aerosolized adenosine required to reduce dynamic compliance of the lung by 50%. No effect of the mismatched control oligonucleotide upon PC50 values was observed. No toxicity was observed in any animal receiving either anti-sense or control inhaled oligonucleotide. These results show clearly that the lung has exceptional potential as a target for anti-sense oligonucleotide-based therapeutic intervention in lung disease. They further show, in a model system which closely resembles human asthma, that downregulation of the adenosine A, receptor largely eliminates adenosine-mediated bronchoconstriction in asthmatic airways. Bronchial hyperresponsiveness in the allergic rabbit model of human asthma is an excellent endpoint for anti-sense intervention since the tissues involved in this response lie near to the point of contact with aerosolized oligonucleotides, and the model closely simulates an important human disease. Example 4: Specificity of A,-adenosine Receptor Anti-sense Oligonucleotide WO 00/09525 PCT/US99/17712 EPI-109 256 At the conclusion of the cross-over experiment of Example 3 above, airway smooth muscle from all rabbits was quantitatively analyzed for adenosine A, receptor number. As a control for the specificity of the anti sense oligonucleotide, adenosine A 2 receptors, which should not have been affected, were also quantified. Airway smooth muscle tissue was dissected from each rabbit and a membrane fraction prepared according to the method of Kleinstein et al. (Kleinstein, J. and Glossmann, H., Naunyn-Schmiedeberg's Arch. Pharmacol. 305: 191-200 (1978)), the relevant portion of which is hereby incorporated in its entirety by reference, with slight modifications. Crude plasma membrane preparations were stored at 70EC until the time of assay. Protein content was determined by the method of Bradford (M. Bradford, Anal. Biochem. 72, 240-254 (1976), the relevant portion of which is hereby incorporated in its entirety by reference). Frozen plasma membranes were thawed at room temperature and were incubated with 0.2 U/ml adenosine deaminase for 30 minutes at 37EC to remove endogenous adenosine. The binding of [ 3 H] DPCPX (A, receptor-specific) or [ 3 H] CGS-21680 (A, receptor-specific) was measured as previously described by Ali et al. (Ali, S. et al., J. Pharmacol. Exp. Ther. 268, Am. J. Physiol 266, L271-277 (1994), the relevant portion of which is hereby incorporated in its entirety by reference). The animals treated with adenosine A, anti-sense oligonucleotide in the cross-over experiment had a nearly 75% decrease in A, receptor number compared to controls, as assayed by specific binding of the A,-specific antagonist DPCPX. There was no change in adenosine A, receptor number, as assayed by specific binding of the A 2 receptor-specific agonist 2- [p (2-carboxyethyl)-phenethylamino] -5' - (N-ethylcarboxamido) adenosine (CGS-21680). This is illustrated in Table 4 below. Table 4:Specificity of Action of Adenosine A, Receptor Anti-sense Oligonucleotide Mismatch Control A, Anti-sense Oligonucleotide Oligonucleotide A,-Specific Binding 1105 1 48** 293 1 18 A-Specific Binding 302+22 442 + 171 The results are presented as the mean (n = 8) 1 SEM. The significance was determined by repeated-measures analysis of variance (ANOVA), and Tukey's protected test. **Significantly different from mismatch control, p<0.01. The above results illustrate the effectiveness of anti-sense oligonucleotides in treating airway disease. Since the anti-sense oligos described above. eliminate the receptor systems responsible for adenosine-mediated bronchoconstriction, it may be less imperative to eliminate adenosine from them. However, it would be preferable to eliminate adenosine from even these oligonucleotides to reduce the dose needed to attain a similar effect. Described above are other anti-sense oligonucleotides targeting mRNA of proteins involved in inflammation. Adenosine has been eliminated from their nucleotide content to prevent its liberation during degradation. Example 5: Anti-sense Oligos directed to other Target Nucleic Acids This work was conducted to demonstrate that the present invention is broadly applicable to anti-sense oligonucleotides ("oligos") specific to nucleic acid targets broadly. The following experimental studies were conducted to show that the method of the invention is broadly suitable for use with anti-sense oligos designed as taught by this application and targeted to any and all adenosine receptor mRNAs. For this purpose, various anti sense oligos were porepared to adenosine receptor mRNAs exemplified by the adenosine A,, A 2 b and A, receptor mRNAs. Anti-sense Oligo I was disclosed above (SEQ. ID NO:1).Five additional anti-sense phosphorothioate oligos were designed asnd synthesized as indicated above. 1- Oligo II (SEQ. ID NO: 7) also targeted to the adenosine A, receptor, but to a different region than Oligo I. 2- Oligo V (SEQ. ID NO: 10) targeted to the adenosine Alb receptor. 3- Oligos III (SEQ. ID NO: 8) and IV (SEQ. ID NO: 9) targeted to different regions of the adenosine A, receptor. 4- Oligo I-PD (SEQ. ID NO: 1681)(a phosphodiester oligo of the same sequence as Oligo I). These anti-sense oligos were designed for therapy on a selected species as described above and are generally specific for that species, unless the segment of the target mRNA of other species happens to contain a similar sequences. All anti-sense oligos were prepared as described below, and tested in vivo in a rabbit model for bronchoconstriction, inflammation and allergy, which have breathing difficulties and impeded lung airways, as is the case in ailments such as asthma, as described in the above-identified application. Example 6: Design & Sequences of other Anti-sense Oligos WO 00/09525 PCT/US99/17712 EPI-109 257 Six oligos and their effects in a rabbit model were studied and the results of these studies are reported and discussed below. Five of these oligos were selected for this study to complement the data on Oligo I (SEQ ID NO: 1) provided in Examples 1 to 4 above. This oligo is anti-sense to one region of the adenosine A, receptor mRNA. The oligos tested are identified as anti-sense Oligos I (SEQ ID NO: 1) and II (SEQ. ID No: 7) targeted to a different region of the adenosine A, receptor mRNA, Oligo V (SEQ. ID No:8) targeted to the adenosine A 2 , receptor mRNA, and anti-sense Oligos III and IV (SEQ. ID NOS: 9 and 10) targeted to two different regions of the adenosine A, receptor mRNA. The sixth oligo (Oligo I-PD) is a phosphodiester version of Oligo I (SEQ. ID NO:1). The design and synthesis of these anti-sense oligos was performed in accordance with Example 1 above. (I) Anti-sense Oligo I: The anti-sense oligonucleotide I referred to in Examples 1 to 4 above is targeted to the human A, adenosine receptor mRNA (EPI 2010). Anti-sense oligo I is 21 nucleotide long, overlaps the initiation codon, and has the following sequence: 5'- GAT GGA GGG CGG CAT GGC GGG -3' (:SEQ. ID No 1). The oligo I was previously shown to abrogate the adenosine-induced bronchoconstriction in allergic rabbits, and to reduce allergen-induced airway obstruction and bronchial hyperresponsiveness (BHR), as discussed above and shown by Nyce, J. W. & Metzger, W. J., Nature, 385:721 (1977), the relevant portions of which reference are incorporated in their entireties herein by reference. (II) Anti-sense Oligo II: A phosphorothioate anti-sense oligo (SEQ. ID NO:7) was designed in accordance with the invention to target the rabbit adenosine A, receptor mRNA region +936 to +956 relative to the initiation codon (start site). The anti-sense oligo II is 21 nucleotide long, and has the following sequence: 5'-CTC GTC GCC GTC GCC GGC GGG-3' (SEQ. ID NO:7). (III) Anti-sense Oligo III: A phosphorothioate anti-sense oligo other than that provided in Example I above (SEQ. ID NO:8) was designed in accordance with the invention to target the anti-sense A 3 receptor mRNA region +3 to + 22 relative to the initiation codon start site. The anti-sense oligo III is 20 nucleotide long, and has the following sequence: 5'-GGG TGG TGC TAT TGT CGG GC-3' (SEQ. ID NO:8). (IV) Anti-sense Oligo IV: Yet another phosphorothioate anti-sense oligo (SEQ. ID NO:9) was designed in accordance with the invention to target the adenosine A, receptor mRNA region + 386 to + 401 relative to the initiation codon (start site). The anti-sense oligo IV is 15 nucleotide long, and has the following sequence: 5'-GGC CCA GGG CCA GCC-3' (SEQ. ID NO:9). (V) Anti-sense Oligo V: A phosphorothioate anti-sense oligo (SEQ. ID NO:10) was designed in accordance with the invention to target the adenosine A 2 receptor mRNA region -21 to -I relative to the initiation codon (start site). The anti-sense oligonucleotide V is 21 nucleotide long, and has the following sequence: 5'-GGC CGG GCC AGC CGG GCC CGG-3' (SEQ. ID NO:10). (VI) A, Mismatch Oligos: Two different mismatched oligonucleotides having the following sequences were used as controls for anti-sense oligo I (SEQ. ID NO: 1) described in Example 5 above. A, MM2 5'-GTA GGT GGC GGG CAA GGC GGG-3' (SEQ. ID NO:1682) A, MM3 5'-GAT GGA GGC GGG CAT GGC GGG-3' (SEQ. ID NO:1683) Anti-sense oligo I and the two mismatch anti-sense oligos had identical base content and general sequence structure. Homology searches in GENBANK (release 85.0) and EMBL (release 40.0) indicated that the anti-sense oligo I was specific, not only for the human, but also for the rabbit, adenosine A, receptor genes, and that the mismatched controls were not candidates for hybridization with any known human or animal gene sequence. (VII) Anti-sense Oligo A,-PD (Oligo VI): A phosphodiester anti-sense oligo (Oligo VI; SEQ. ID NO:1681) having the same nucleotide sequence as Oligo I was designed as disclosed in the above-identified application. Anti sense oligo I-PD is 21 nucleotide long, overlaps the initiation codon, and has the following sequence: 5'- GAT GGA GGG CGG CAT GGC GGG -3' (SEQ. ID NO:1681) (VIII) Controls: Each rabbit was administered 5.0 ml aerosolized sterile saline following the same schedule as for the anti-sense oligos in (II), (III), and (IV) above. Example 7: Synthesis of Anti-sense Oligos Phosphorothioate anti-sense oligos having the sequences described in (a) above, were synthesized on an Applied Biosystems Model 396 Oligonucleotide Synthesizer, and purified using NENSORB chromatography (DuPont, DE). TETD (tetraethylthiuram disulfide) was used as the sulfurizing agent during the synthesis. Anti sense oligonucleotide II (SEQ. ID NO:7), anti-sense oligonucleotide III (SEQ. ID NO: 8) and anti-sense oligonucleotide IV (SEQ. ID NO: 9) were each synthesized and purified in this manner. Example 8: Preparation of Allergic Rabbits WO 00/09525 PCT/US99/17712 EPI-109 258 Neonatal New Zealand white Pasturella-free rabbits were immunized intraperitoneally within 24 hours of birth with 0.5 ml of 312 antigen units/mil house dust mite (D.farinae) extract (Berkeley Biologicals, Berkeley, CA) mixed with 10% kaolin as previously described (Metzger, W. J., in Late Phase Allergic Reactions, Dorsch, W., Ed., CRC Handbook, pp. 347-362, CRC Press, Boca Raton (1990); Ali, S., Metzger, W. J. and Mustafa, S. J., Am. J. Resp. Crit. Care Med. 149: 908 (1994)), the relevant portions of which are incorporated in their entireties here by reference. Immunizations were repeated weekly for the first month and then biweekly until the age of 4 months. These rabbits preferentially produce allergen-specific IgE antibody, typically respond to aeroallergen challenge with both an early and late-phase asthmatic response, and show bronchial hyper responsiveness (BHR). Monthly intraperitoneal administration of allergen (312 units dust mite allergen, as above) continues to stimulate and maintain allergen-specific IgE antibody and BHR. At 4 months of age, sensitized rabbits were prepared for aerosol administration as described by Ali et al. (Ali, S., Metzger, W. J. and Mustafa, S. J., Am. J. Resp. Crit. Care Med. 149 (1994)), the relevant section being incorporated in its entirety here by reference. DOSE-RESPONSE STUDIES Example 9: Experimental Setup Aerosols of either adenosine (0-20 mg/ml), or anti-sense or one of two mismatch oligonucleotides (5 mg/ml) were separately prepared with an ultrasonic nebulizer (Model 646, DeVilbiss, Somerset, PA), which produced aerosol droplets, 80% of which were smaller than 5:m in diameter. Equal volumes of the aerosols were administered directly to the lungs via an intratracheal tube. The animals were randomized, and administered aerosolized adenosine. Day 1 pre-treatment values for sensitivity to adenosine were calculated as the dose of adenosine causing a 50% loss of compliance (PC 5 Adenosine). The animals were then administered either the aerosolized anti-sense or one of the mismatch anti-sense oligos via the intratracheal tube (5 mg/1.0 ml), for 2 minutes, twice daily for 2 days (total dose, 20 mg). Post-treatment PC 5 0 values were recorded (post-treatment challenge) on the morning of the third day. The results of these studies are provided in Example 21 below. Example 10: Crossover Experiments For some experiments utilizing anti-sense oligo I (SEQ ID NO: 1) and a corresponding mismatch control oligonucleotide AlMM2, following a 2 week interval, the animals were crossed over, with those previously administered the mismatch control AMM2, now receiving the anti-sense oligo I, and those previously treated with the anti-sense oligo I, now receiving the mismatch control AMM2 oligo. The number of animals per group was as follows. For mismatch AMM2 (Control 1), n=7, since one animal was lost in the second control arm of the experiment due to technical difficulties, for mismatch AMM3 n=4 (Control 2) and for AAS anti-sense oligo I, n=8. The AMM3 oligo-treated animals were analyzed separately and were not part of the cross-over experiment. The treatment methods and measurements employed following the cross-over were identical to those employed in the first arm of the experiment. In 6 of the 8 animals treated with the anti-sense oligo I (SEQ. ID NO: 1), no PC,, value could be obtained for adenosine doses of up to 20 mg/ml, which is the limit of solubility of adenosine. Accordingly, the PC,, values for these animals were assumed to be 20 mg/ml for calculation purposes. The values given, therefore, represent a minimum figure for the effectiveness of the anti-sense oligonucleotides of the invention. Other groups of allergic rabbits (n=4 for each group) were administered 0.5 or 0.05 mg doses of the anti sense oligo I (SEQ ID NO: 1), or the AMM2 oligo in the manner and according to the schedule described above (the total doses being 2.0 or 0.2 mg). The results of these studies are provided in Example 22 below. Example 11: Anti-sense Oligo Formulation Each one of anti-sense oligos were separately solubilized in an aqueous solution and administered as described for anti-sense oligo I (SEQ. ID No:1) in (e) above, in four 5 mg aliquots (20 mg total dose) by means of a nebulizer via endotracheal tube, as described above. The results obtained for anti-sense oligo I and its mismatch controls confirmed that the mismatch controls are equivalent to saline, as described in Example 19 below and in Table I of Nyce & Metzger, Nature 385, 721-725 (1997). Because of this finding, saline was used as a control for pulmonary function studies employing anti-sense oligos II, III and IV (SEQ. ID NOS; 7, 8 and 9). Example 12: Specificity of Oligo I for Adenosine A, Receptor (Receptor Binding Studies) Tissue from airway smooth muscle was dissected to primary, secondary and tertiary bronchi from rabbits which had been administered 20 mg oligo I (SEQ ID NO: 1) in 4 divided doses over a period of 48 hours as described above. A membrane fraction was prepared according to the method of Ali et al. (Ali, S., et al., Am. J. Resp. Crit. Care Med. 149: 908 (1994), the relevant section relating to the preparation of the membrane fraction is incorporated in its entirety hereby by reference). The protein content was determined by the method of Bradford WO 00/09525 PCTIUS99/17712 EPI-109 259 and plasma membranes were incubated with 0.2 U/ml adenosine deaminase for 30 minutes at 37EC to remove endogenous adenosine. See, Bradford, M. M. Anal. Biochem. 72, 240-254 (1976), the relevant portion of which is hereby incorporated in its entirety by reference. The binding of [ 3 H]DPCPX, [ 3 H]NPC17731, or [ 3 H]CGS-21680 was measured as described by Jarvis et al. See, Jarvis, M.F., et al., Pharmacol. Exptl. Ther. 251, 888-893 (1989), the relevant portion of which is fully incorporated herein by reference. The results of this study are shown in Table 8 and discussed in Example 20 below. Example 13: Pulmonary Function Measurements (Compliance c,, and Resistance) At 4 months of age, the immunized animals were anesthetized and relaxed with 1.5 ml of a mixture of ketamine HCI (35 mg/kg) and acepromazine maleate (1.5 mg/kg) administered intramuscularly. After induction of anesthesia, allergic rabbits were comfortably positioned supine on a soft molded animal board. Salve was applied to the eyes to prevent drying, and they were closed. The animals were then intubated with a 4.0 mm intermediate high-low cuffed Murphy 1 endotracheal tube (Mallinckrodt, Glen Falls, NY), as previously described by Zavala and Rhodes. See, Zavala and Rhodes, Proc. Soc. Exp. Biol. Med. 144: 509-512 (1973), the relevant portion of which is incorporated herein by reference in its entirety. A polyethylene catheter of OD 2.4 mm (Becton Dickinson, Clay Adams, Parsippany NJ) with an attached thin-walled latex balloon was passed into the esophagus and maintained at the same distance (approximately 16 cm) from the mouth throughout the experiment. The endotracheal tube was attached to a heated Fleisch pneumotach (size 00; DEM Medical, Richmond, VA), and the flow (v) measured using a Validyne differential pressure transducer (Model DP-45-16-1927, Validyne Engineering, Northridge, CA), driven by a Gould carrier amplifier (Model 11-4113, Gould Electronics, Cleveland, OH). An esophageal balloon was attached to one side of the Validyne differential pressure transducer, and the other side was attached to the outflow of the endotracheal tube to obtain transpulmonary pressure (P,). The flow was integrated to yield a continuous tidal volume, and the measurements of total lung resistance (R) and dynamic compliance (Cyd) were made at isovolumetric and zero flow points. The flow, volume and pressure were recorded on an eight channel Gould 2000 W high-frequency recorder and Cy, was calculated using the total volume and the difference in PT at zero flow, and . R, was calculated as the ratio of Ptp and V at midtidal lung volumes. These calculations were made automatically with the Buxco automated pulmonary mechanics respiratory analyzer (Model 6, Buxco Electronics, Sharon, CT), as previously described by Giles et al. See, Giles et al., Arch. Int. Pharmacodyn. Ther. 194: 213-232 (1971), the relevant portion of which describing these calculations is incorporated in toto hereby by reference. The results obtained upon administration of oligo II on allergic rabbits are shown and discussed in Example 26 below. Example 14: Measurement of Bronchial Hyperresponsiveness (BHR) Each allergic rabbit was administered histamine by aerosol to determine their baseline hyperresponsiveness. Aerosols of either saline or histamine were generated using a DeVilbiss nebulizer (DeVilbiss, Somerset, PA) for 30 seconds and then for 2 minutes at each dose employed. The ultrasonic nebulizer produced aerosol droplets of which 80% were <5 micron in diameter. The histamine aerosol was administered in increasing concentrations (0.156 to 80 mg/ml) and measurements of pulmonary function were made after each dose. The B4R was then determined by calculating the concentration of histamine (mg/mil) required to reduce the Cdyn 50% from baseline (PC0 Hisamine) Example 15: Cardiovascular Effect of Anti-sense Oligo I The measurement of cardiac output and other cardiovascular parameters using CardiomaxJ utilizes the principal of thermal dilution in which the change in temperature of the blood exiting the heart after a venous injection of a known volume of cool saline is monitored. A single rapid injection of cool saline was made into the right atrium via cannulation of the right jugular vein, and the corresponding changes in temperature of the mixed injectate and blood in the aortic arch were recorded via cannulation of the carotid artery by a temperature-sensing miniprobe. Twelve hours after the allergic rabbits had been treated with aerosols of oligo I (EPI 2010; SEQ. ID NO: 1) as described in (d) above, the animals were anesthetized with 0.3 ml/kg of 80% Ketamine and 20% Xylazine. This time point coincides with previous data showing efficacy for SEQ. ID NO: 1, as is clearly shown by Nyce & Metzger, (1997), supra, the pertinent disclosure being incorporated in its entirety here by reference. A thermocouple was then inserted into the left carotid artery of each rabbit, and was then advanced 6.5 cm and secured with a silk ligature. The right jugular vein was then cannulated and a length of polyethylene tubing was inserted and secured. A thermodilution curve was then established on a CardiomaxJ II (Columbus Instruments, Ohio) by injecting sterile saline at 20EC to determine the correctness of positioning of the WO 00/09525 PCT/US99/17712 EPI-109 260 thermocouple probe. After establishing the correctness of the position of the thermocouple, the femoral artery and vein were isolated. The femoral vein was used as a portal for drug injections, and the femoral artery for blood pressure and heart rate measurements. Once constant baseline cardiovascular parameters were established, CardiomaxJ measurements of blood pressure, heart rate, cardiac output, total peripheral resistance, and cardiac contractility were made. Example 16: Duration of Action of Oligo I (SEQ. ID NO: 1) Eight allergic rabbits received initially increasing log doses of adenosine by means of a nebulizer via an intra-tracheal tube as described in (f) above, beginning with 0.156 mg/ml until compliance was reduced by 50% (PC5 0 Adenosn) to establish a baseline. Six of the rabbits then received four 5 mg aerosolized doses of (SEQ. ID NO: 1) as described above. Two rabbits received equivalent amounts of saline vehicle as controls. Beginning 18 hours after the last treatment, the PC5 0 Adcnsnc values were tested again. After this point, the measurements were continued for all animals each day, for up to 10 days. The results of this study are discussed in Example 25 below. Example 17: Reduction of Adenosine A 2 , Receptor Number by Anti-sense Oligo V Sprague Dawley rats were administered 2.0 mg respirable anti-sense oligo V (SEQ ID NO: 10) three times over two days using an inhalation chamber as described above. Twelve hours after the last administration, lung parenchymal tissue was dissected and assayed for adenosine Alb receptor binding using [311 ]-NECA as described by Nyce & Metzger (1997), supra. Controls were conducted by administration of equal volumes of saline. The results are significant at p<0.05 using Student's paired t test, and are discussed in Example 28 below. Example 18: Comparison of Oligo I & Corresponding Phosphodiester Oligo VI (SEQ. ID NO:1681) Oligo I (SEQ ID NO:1) countered the effects of adenosine and eliminated sensitivity to it for adenosine amounte up to 20 mg adenosine/5.0 ml (the limit of solubility of adenosine). Oligo VI (SEQ ID NO:1681), the phosphodiester version of the oligonucleotide sequence, was completely ineffective when tested in the same manner. Both compounds have identical sequence, differing only in the presence of phosphorothioate residues in Oligo I (SEQ ID NO:1), and were delivered as an aerosol as described above and in Nyce & Metzger (1997), supra. Significantly different at p<0.001, Student's paired t test. The results are discussed in Example 29 below.. RESULTS OBTAINED FOR ANTI-SENSE OLIGO I (SEQ. ID NO: 1) Example 19: Results of Prior Work The nucleotide sequence and other data for anti-sense oligo I (SEQ. ID NO: 1), which is specific for the adenosine A, receptor, were provided above. The experimental data showing the effectiveness of oligo I in down regulating the receptor number and activity were also provided above. Further information on the characteristics and activities of anti-sense oligo I is provided in Nyce, J. W. and Metzger, W. J., Nature 385:721 (1997), the relevant parts of which relating to the following results are incorporated in their entireties herein by reference. The Nyce & Metzger (1997) publication provided data showing that the anti-sense oligo I (SEQ. ID NO: 1): (1) The anti-sense oligo I reduces the number of adenosine A, receptors in the bronchial smooth muscle of allergic rabbits in a dose-dependent manner as may be seen in Table 5. (2) Anti-sense Oligo I attenuates adenosine-induced bronchoconstriction and allergen-induced bronchoconstriction. (3) The Oligo I attenuates bronchial hyperresponsiveness as measured by PC, 0 histamine, a standard measurement to assess bronchial hyperresponsiveness. This result clearly demonstrates anti-inflammatory activity of the anti sense oligo I as is shown in Table 5. (4) As expected, because it was designed to target it, the anti-sense oligo I is totally specific for the adenosine A, receptor, and has no effect at all at any dose on either the very closely related adenosine A 2 receptor or the related bradykinin B 2 receptor. This is seen in Table 5. (5) In contradistinction to the above effects of the Oligo I, the mismatch control molecules MM2 and MM3 (SEQ. ID NO:1682 and SEQ. ID NO:1683) which have identical base composition and molecular weight but differed from the anti-sense oligo I (SEQ ID NO: 1) by 6 and 2 mismatches, respectively. These mismatches, which are the minimum possible while still retaining identical base composition, produced absolutely no effect upon any of the targeted receptors (A 1 , A 2 or B 2 ). These results, along with a complete lack of prior art on the use of anti-sense oligonucleotides, such as oligo I, targeted to the adenosine A, receptor, are unexpected results. The showings presented in this patent clearly enable and demonstrate the effectiveness, for their intended use, of the claimed agents and method for treating a disease or condition associated with lung airway, such as bronchoconstriction, inflammation, allergy(ies), and the like.
WO 00/09525 PCT/US99/17712 261 Example 20: Oligo I Significantly Reduces Response to Adenosine Challenge The receptor binding experiment is described in Example 12 above, and the results shown in Table 5 below which shows the binding characteristics of the adenosine A,-selective ligand [ 3 H]DPCPX and the bradykinin B-selective ligand [ 3 HJNPC 17731 in membranes isolated from airway smooth muscle of A, adenosine receptor and B. bradykinin receptor anti-sense- and mismatch-treated allergic rabbits. Table 5: Binding Characteristics of Three Anti-Sense Oligos Treatment' A, receptor B 2 receptor Kd B. Kd Bmax Adenosine A, Receptor 20 mg 0.36+0.029 nM 19+1.52 fmoles* 0.39+0.031 nM 14.8+0.99fmoles 2 mg 0.38+0.030 nM 32+2.56 fmoles* 0.41+0.028 nM 15.5+1.08 fmoles 0.2 mg 0.37+0.030 nM 49+3.43 fmoles 0.34+0.024 nM 15.0+1.06 fmoles
A
1 MM1 (Control) 20 mg 0.34+0.027 nM 52.0+3.64 fmoles 0.35+0.024 nM 14.0+1.0 fmoles 2 mg 0.37+0.033 nM 51.8+3.88 fmoles 0.38+0.028 nM 14.6+1.02 fmnotes B2A (Bradykinin Receptor) 20 mg 0.36+0.028 nM 45.0+0.15 fnoles 0.38+0.027 nM 8.7+0.62 fmoles* 2 mg 0.39+0.035 nM 44.3+2.90 files 0.34+0.024 nM 11.9+0.76 fnoles** 0.2 mg 0.40+0.028 nM 47.0+3.76 fnoles 0.35+0.028 nM 15.1+1.05 fimoles B2MM (Control) + 20 mg 0.39+0.031 nM 42.0+2.94 finoles 0.41+0.029 nM 14.0+0.98 fnoles 2 mg 0.41+0.035 nM 40.0+3.20 finoles 0.37+0.030 nM 14.8+0.99 fmoles 0.2 mg 0.37+0.029 nM 43.0+3.14 fmoles 0.36+0.025 nM 15.1+1.35 fmoles Saline Control 0.37+0.041 46.0+5.21 0.39+0.047 nIM 14.2+1.35 fmoles Refers to total oligo aamminstereo in tour equivalently divided doses over a 48 hour period. Treatments and analyses were performed as descnbed in methods. Significance was determined by repeated-measures analysis of vanance (ANOVA), anlukey's protected t test. n = 4-6 for all groups. Significantly different from mismatch control- and saline-treated groups, p<0.001; Significantly different from mismatch control- and saline-treated groups, p<0.05. Example 21: Dose-response Effect of Oligo I Anti-sense oligo I (SEQ ID NO:1) was found to reduce the effect of adenosine administration to the animal in a dose-dependent manner over the dose range tested as shown in Table 6 below.
WO 00/09525 PCT/US99/17712 EPI-109 262 Table 6:Dose-Response Effect to Anti-sense Oligo I Total Dose
PC
50 Adenossne (mg) (mg Adenosine) Anti-sense Oligo I 0.2 8.32+7.2 2.0 14.0+7.2 20 19.5+0.34 A,MM2 oligo (control) 0.2 2.51+0.46 2.0 3.13+0.71 20 3.25+0.34 The above results were found by the Student's paired t test statistically different, p=0.05 The oligo I (SEQ. ID NO:1), an anti-adenosine A, receptor oligo, acts specifically on the adenosine A, receptor, but not on the adenosine A, receptors. These results stem from the treatment of rabbits with anti-sense oligo I (SEQ. ID NO.1) or mismatch control oligo (SEQ. ID NO:1682; A,MM2) as described in Example 9 above and in Nyce & Metzger (1997), supra (four doses of 5 mg spaced 8 to 12 hours apart via nebulizer via endotracheal tube), bronchial smooth muscle tissue excised and the number of adenosine A, and adenosine A, receptors determined as reported in Nyce & Metzger (1997), supra. Example 22: Specificity of Oligo I (SEQ. ID NO:1) for Target Gene Product Oligo I (SEQ. ID No:1) is specific for the adenosine A, receptor whereas its mismatch controls had no activity. Figure 1 depicts the results obtained from the cross-over experiment described in Example 10 above and in Nyce & Metzger (1997), supra. The two mismatch controls (SEQ. ID NO:1682 and SEQ. ID NO:1683) evidenced no effect on the PC 50 AdO e value. On the contrary, the administration of anti-sense oligo I (SEQ. ID NO:1) showed a seven-fold increase in the PC 50 A&CIi., value. The results clearly indicate that the anti-sense oligo I (SEQ. ID NO: 1) reduces the response (attenuates the sensitivity) to exogenously administered adenosine when compared with a saline control. The results provided in Table 2 above clearly establish that the effect of the anti sense oligo I is dose dependent (see, column 3 of Table 1). The Oligo I was also shown to be totally specific for the adenosine A, receptor, (see, top 3 rows of Table), inducing no activity at either the closely related adenosine A, receptor or the bradykinin B, receptor (see, lines 8-10 of Table 2 above). In addition, the results shown in Table 2 establish that the anti-sense oligo I (SEQ. ID NO:1) decreases sensitivity to adenosine in a dose dependent manner, and that it does this in an anti-sense oligo-dependent manner since neither of two mismatch control oligonucleotides (A,MM2; SEQ. ID NO:1682 and AMM3; SEQ. ID NO:1683) show any effect on PC,, Admoine values or on attenuating the number of adenosine A, receptors. Example 23: Effect on Aeroallergen-induced Bronchoconstriction & Inflammation The Oligo I (SEQ. ID NO:1) was shown to significantly reduce the histamine-induced effect in the rabbit model when compared to the mismatch oligos. The effect of the anti-sense Oligo I (SEQ. ID No: 1) and the mismatch oligos (A,MM2, SEQ. ID NO:1682 and A,MM3, SEQ. ID NO:1682) on allergen-induced airway obstruction and bronchial hyperresponsiveness was assessed in allergic rabbits. The effect of the anti-sense oligo I (SEQ. ID NO:1) on allergen-induced airway obstruction was assessed. As calculated from the area under the plotted curve, the anti-sense oligo I significantly inhibited allergen-induced airway obstruction when compared with the mismatched control (55%, p<0.05; repeated measures ANOVA, and Tukey's t test). A complete lack of effect was induced by the mismatch oligo A,MM2 (Control) on allergen induced airway obstruction. The effect of the anti-sense oligo I (SEQ. ID NO:1) on allergen-induced BHR was determined as above. As calculated from the PC50 Histamine value , the anti-sense oligo I (SEQ. ID NO:1) significantly inhibited allergen-induced BHR in allergic rabbits when compared to the mismatched control (61%, p<0.05; repeated measures ANOVA, Tukey's t test). A complete lack of effect of the A,MM mismatch control on allergen-induced BHR was observed. The results indicated that anti-sense oligo I (SEQ. ID NO: 1) is effective to protect against aeroallergen-induced bronchoconstriction (house dust mite). In addition, the anti-sense oligo I (SEQ. ID NO:1) was also found to be a WO 00/09525 PCT/US99/17712 EPI-109 263 potent inhibitor of dust mite-induced bronchial hyper responsiveness, as shown by its effects upon histamine sensitivity which indicates anti- inflammatory activity for anti-sense oligo I (SEQ. ID NO:1). Example 24: Anti-sense Oligo I is Free of Deleterious Side Effects The Oligo I (SEQ. ID NO:1) was shown to be free of side effects that might be toxic to the recipient. No changes in arterial blood pressure, cardiac output, stroke volume, heart rate, total peripheral resistance or heart contractility (dPdT) were observed following administration of 2.0 or 20 mg oligo I (SEQ. ID NO:1). The addition, the results of the measurement of cardiac output (CO), stroke volume (SV), mean arterial pressure (MAP), heart rate (HR), total peripheral resistance (TPR), and contractility (dPdT) with a CardiomaxJ apparatus (Columbus Instruments, Ohio) were assessed. These results evidenced that oligo I (SEQ. ID NO:1) has no detrimental effect upon critical cardiovascular parameters. More particularly, this oligo does not cause hypotension. This finding is of particular importance because other phosphorothioate anti-sense oligonucleotides have been shown in the past to induce hypotension in some model systems. Furthermore, the adenosine A, receptor plays an important role in sinoatrial conduction within the heart. Attenuation of the adenosine A, receptor by anti-sense oligo I (SEQ. ID NO:1) might be expected to result, therefore, in deleterious extrapulmonary activity in response to the downregulation of the receptor. This is not the case. The anti-sense oligo I (SEQ. ID NO:1) does not produce any deleterious intrapulmonary effects and renders the administration of the low doses of the present anti-sense oligo free of unexpected, undesirable side effects. This demonstrates that when oligo I (SEQ. ID NO:1) is administered directly to the lung, it does not reach the heart in significant quantities to cause deleterious effects. This is in contrast to traditional adenosine receptor antagonists like theophylline which do escape the lung and can cause deleterious, even life-threatening effects outside the lung. Example 25: Long Lasting Effect of Oligo I The Oligo I (SEQ. ID NO:1) evidenced a long lasting effect as evidenced by the PC 5 and Resistance values obtained upon its administration prior to adenosine challenge. The duration of the effect was measured for with respect to the PC, 0 of adenosine anti-sense oligo I when administered in four equal doses of 5 mg each by means of a nebulizer via an endotracheal tube, as described above. The effect of the agent is significant over days I to 8 after administration. When the effect of the anti-sense oligo I (SEQ. ID NO:1) had disappeared, the animals were administered saline aerosols (controls), and the PC,, e,,i values for all animals were measured again. Saline-treated animals showed base line PC 5 , adenosine values (n=6). The duration of the effect (with respect to Resistance) was measured for six allergic rabbits which were administered 20 mg of anti-sense oligo I (SEQ. ID NO: 1) as described above, upon airway resistance measured as also described above. The mean calculated duration of effect was 8.3 days for both PC,, adenosine (p<0.05) and resistance (p<0.05). These results show that anti-sense oligo I (SEQ. ID NO:1) has an extremely long duration of action, which is completely unexpected. Example 26: Anti-sense Oligo II Anti-sense oligo II, targeted to a different region of the adenosine A, receptor mRNA, was found to be highly active against the adenosine A,-mediated effects. The experiment measured the effect of the administration of anti-sense oligo II (SEQ. ID NO:7) upon compliance and resistance values when 20 mg anti-sense oligo II or saline (control) were administered to two groups of allergic rabbits as described above. Compliance and resistance values were measured following an administration of adenosine or saline as described above in Example 13. The effect of the anti-sense oligo of the invention was different from the control in a statistically significant manner, p<0.05 using paired t-test, compliance; p<0.01 for resistance. The results showed that anti-sense oligo II (SEQ. ID NO:7), which targets the adenosine A, receptor, effectively maintains compliance and reduces resistance upon adenosine challenge. Example 27: Antisense Oligos III and IV Oligos III (SEQ. ID NO:8) and IV (SEQ. ID NO:9) were shown to be in fact specifically targeted to the adenosine A, receptor by their effect on reducing inflammation and the number of inflammatory cells present upon separate administration of 20 ing of the anti-sense oligos III (SEQ. ID NO:8) and IV (SEQ. ID NO:9) to allergic rabbits as described above. The number of inflammatory cells was determined in their bronchial lavage fluid 3 hours later by counting at least 100 viable cells per lavage. The effect of anti-sense oligos III (SEQ. ID NO:8) and IV (SEQ. ID NO:9) upon granulocytes, and upon total cells in bronchial lavage were assessed following exposure to dust mite allergen. The results showed that the anti-sense oligo IV (SEQ. ID NO:9) and anti-sense oligo III (SEQ. ID NO:8) are very potent anti-inflammatory agents in the asthmatic lung following exposure to dust mite allergen. As is known in the art, granulocytes, especially eosinophils. are the primary inflammatory cells of WO 00/09525 PCTIUS99/17712 EPI-109 264 asthma, and the administration of anti-sense oligos III (SEQ. ID NO:8) and IV (SEQ. ID NO:9) reduced their numbers by 40% and 66%, respectively. Furthermore, anti-sense oligos IV (SEQ. ID NO:9) and III (SEQ. ID NO:8) also reduced the total number of cells in the bronchial lavage fluid by 40% and 80%, respectively. This is also an important indicator of anti-inflammatory activity by the present anti-adenosine A, agents of the invention. Inflammation is known to underlie bronchial hyperresponsiveness and allergen-induced bronchoconstriction in asthma. Both anti-sense oligonucleotides III (SEQ. ID NO:8) and IV (SEQ. ID NO:9), which are targeted to the adenosine A, receptor, are representative of an important new class of anti-inflammatory agents which may be designed to specifically target the lung receptors of each species. Example 28: Anti-sense Oligo V The anti-sense oligo V (SEQ. ID NO:10) , targeted to the adenosine A 2 b adenosine receptor mRNA was shown to be highly effective at countering adenosine A2b-mediated effects and at reducing the number of adenosine
A
2 b receptors present to less than half. Example 29: Unexpected Superiority of Substituted over Phosphodiester-residue Oligo I-DS(SEQ.ID NO:1681) Oligos I (SEQ. ID NO:1) and I-DS (SEQ. ID NO:1681) were separately administered to allergic rabbits as described above, and the rabbits were then challenged with adenosine. The phosphodiester oligo I-DS (SEQ. ID NO:1681) was statistically significantly less effective in countering the effect of adenosine whereas oligo I (SEQ. ID NO:1) showed high effectiveness, evidencing a PCO ie of 20 mg. Example 30: Anti-sense Oligo VI For the present work, I designed an additional anti-sense phosphorothioate oligo targeted to the adenosine A, receptor (Oligo VI). This anti-sense oligo was designed for therapy on a selected species as described in the above patent application and is generally specific for that species, unless the segment of the adenosine receptor mRNA of other species elected happens to have a similar sequence. The anti-sense oligos were prepared as described below, and tested in vivo in a rabbit model for bronchoconstriction, inflammation and lung allergy, which have breathing difficulties and impeded lung airways, as is the case in ailments such as asthma, as described in the above-identified application. One additional oligo and its effect in a rabbit model was studied and the results of the study are reported and discussed below. The present oligo (anti-sense oligo VI) was selected for this study to complement the data on SEQ ID NO: 1 (Oligo I), which is anti-sense to the adenosine A, receptor mRNA provided in the above-identified patent application. This additional oligo is identified as anti-sense Oligo VI, and is targeted to a different region of the adenosine A, receptor mRNA than Oligo I. The design and synthesis of this anti-sense oligo was performed in accordance with the teaching, particularly Example 1, of the above-identified patent application. The anti-sense Oligo VI is a phosphorothioate designed to target the coding region of the rabbit adenosine A, receptor mRNA region +964 to +984 relative to the initiation codon (start site). The Oligo VI was prepared as described in the above-indicated application, and is 20 nucleotides long. The OligoVI is directed to the adenosine A, receptor gene, and has the following sequence: 5'-CGC CGG CGG GTG CGG GCC GG-3' (SEQ. ID NO:_). The phosphorothioate anti-sense Oligo VI having the sequence described in (5) above, was synthesized on an Applied Biosystems Model 396 Oligonucleotide Synthesizer, and purified using NENSORB chromatography (DuPont, DE). TETD (tetraethylthiuram disulfide) was used as the sulfurizing agent during the synthesis. Example 31: Preparation of Allergic Rabbits Neonatal New Zealand white Pasturella-free rabbits were immunized intraperitoneally within 24 hours of birth with 0.5 ml of 312 antigen units/ml house dust mite (D. farinae) extract (Berkeley Biologicals, Berkeley, CA) mixed with 10% kaolin as previously described (Metzger, W. J., in Late Phase Allergic Reactions, Dorsch, W., Ed., CRC Handbook, pp 347-362, CRC Press, Boca Raton, 1990; Ali, S. Et al., Am. J. Resp. Crit. Care Med. 149: 908 (1994)). The immunizations were repeated weekly for the first month and then bi-weekly until the animals were 4 months old. These rabbits preferentially produce allergen-specific IgE antibody, typically respond to aeroallergen challenge with both an early and late-phase asthmatic response, and show bronchial hyper responsiveness (BHR). Monthly intraperitoneal administration of allergen (312 units dust mite allergen, as above) continues to stimulate and maintain allergen-specific IgE antibody and BHR. At 4 months of age, sensitized rabbits were prepared for aerosol administration as described by Ali et al. (1994), supra. Example 32: Adenosine Aerosol Preparation An adenosine aerosol (20 mg/ml) was prepared with an ultrasonic nebulizer (Model 646, DeVilbiss, Somerset, PA), which produced aerosol droplets, 80% of which were smaller than 5:m in diameter. Equal volumes of the aerosols were administered directly to the lungs via an intratracheal tube to all three rabbits. The animals WO 00/09525 PCT/US99/17712 EPI-109 265 were then administered the aerosolized adenosine and Day 1 pre-treatment values for sensitivity to adenosine were calculated as the dose of adenosine causing a 50% loss of compliance (PCO Adenosine). The animals were then administered the aerosolized anti-sense via the intratracheal tube (5 mg/1.0 ml), for 2 minutes, twice daily for 2 days (total dose, 20 mg). Post-treatment PC,, values were recorded (post-treatment challenge) on the morning of the third day. The results of these studies are provided in (9) below. Example 33: Anti-sense Oligo Formulation Each one of anti-sense oligos were separately solubilized in an aqueous solution and administered as described for anti-sense oligo I in (e) above, in four 5 mg aliquots (20 mg total dose) by means of a nebulizer via endotracheal tube, as described above. Example 34: Oligo VI Reduces Response to Adenosine Challenge as well or Better than Oligo I Oligo VI was tested in three allergic rabbits of the characteristics and readied as described in (7) above and in the above-indicated patent application. Oligo VI targets a section of the coding region of the A, receptor which is different from Oligo I. Both these target sequences were selected randomly from many possible coding region target sequences. The three rabbits were treated identically as previously indicated for Oligo I. Briefly, 5 mg of Oligo VI were nebulized to the rabbits twice per day at 8 hour intervals, for two days. Thereafter, PC,, adenosine studies were performed on the morning of the third day and compared to pre-treatment PC,, values. This protocol is described in more detail in Nyce and Metzger (Nyce & Metzger, Nature 385: 721-725 (1997)). The results obtained for the three rabbits are shown in Table 1 below. Table 1: PC,, Adenosine before & after Aerosolized Adenosine Treatment Treatment Time PC,, Adenosine (mg) Pre-treatment 3.0+2.1 Post-treatment >20.0* * maximum achievable dose due to adenosine insolubility in saline All three animals treated with Oligo VI completely eliminated sensitivity to adenosine up to the measurable level of the agent shown in Table 1 above. That is, the administration of the Oligo VI abrogated the adenosine-induced bronchoconstriction in the three allergic rabbits. The actual efficacy of Oligo VI is, therefore, greater than could be measured in the experimental system used. By comparing with the previously submitted results for the Oligo I, it may be seen that the Oligo VI was found to be as effective, or more, than Oligo I. Example 34: Conclusions The work described and results discussed in the examples clearly indicates that all anti-sense oligonucleotides designed in accordance with the teachings of the above-identified application were found to be highly effective at countering or reducing effects mediated by the receptors they are targeted to. That is, each and all of the two anti-sense oligos targeting an adenosine A, receptor mRNA, 1 anti-sense oligo targeting an adenosine Alb receptor mRNA, and the 2 anti-sense oligos targeting an A, receptor mRNA were shown capable of countering the effect of exogenously administered adenosine which is mediated by the specific receptor they are targeted to. The activity of the anti-sense oligos of this invention, moreover, is specific to the target and substitutively fails to inhibit another target. In addition, the results presented also show that the administration of the present agents results in extremely low or non-existent deleterious side effects or toxicity. This represents 100% success in providing agents that are highly effective and specific in the treatment of bronchoconstriction and/or inflammation. This invention is broadly applicable in the same manner to all gene(s) and corresponding mRNAs encoding proteins involved in or associated with airway diseases. A comparison of the phosphodiester and a version of the same oligonucleotide wherein the phosphodiester bonds are substituted with phosphorothioate bonds evidenced an unexpected superiority for the phosphothiorate oligonucleotide over the phosphodiester anti-sense oligo. The foregoing examples are illustrative of the present invention, and are not to be construed as limiting thereof. The invention is defined by the following claims, with equivalents of the claims to be included therein.
WO 00/09525 PCT/US99/17712 EPI-109 266 SEQUENCE LISTING (1) GENERAL INFORMATION (i) APPLICANT: East Carolina University et al. (ii) TITLE OF THE INVENTION: LOW ADENOSINE OLIGONUCLEOTIDE AGENT, COMPOSITION, KIT & TREATMENTS (iii) NUMBER OF SEQUENCES: (iv) CORRESPONDENCE ADDRESS: (A) ADDRESSEE: ARTER & MADDEN (B) STREET: 725 South Figueroa St, # 2400 (C) CITY: Los Angeles (D) STATE: CA (E) COUNTRY: USA (F) ZIP: 90071 (v) COMPUTER READABLE FORM: (A) MEDIUM TYPE: Diskette (B) COMPUTER: IBM Compatible (C) OPERATING SYSTEM: DOS (D) SOFTWARE: FastSEQ for Windows Version 2.0 (vi) CURRENT APPLICATION DATA: (A) APPLICATION NUMBER: PCT/US99/ (B) FILING DATE: 3-AUG-1999 (C) CLASSIFICATION: UNKNOWN (vii) PRIOR APPLICATION DATA: (A) APPLICATION NUMBER: 60/095,212 (B) FILING DATE: 03-AUG-1998 (viii) ATTORNEY/AGENT INFORMATION: (A) NAME: Amzel, Viviana (B) REGISTRATION NUMBER: 30,930 (C) REFERENCE/DOCKET NUMBER: EPI-109 (ix) TELECOMMUNICATION INFORMATION: (A) TELEPHONE: 213-430-3520 (B) TELEFAX: 213-617-9255 (C) TELEX: (2) INFORMATION FOR SEQ ID NO:l: (iA SEQUENCE CHARACTERISTICS: (A) LENGTH: 21 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:l: GATGGAGGGC GGCATGGCGG G 21 (2) INFORMATION FOR SEQ ID NO:2: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 21 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2: GTAGCAGGCG GGGATGGGGG C 21 (2) INFORMATION FOR SEQ ID NO:3: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:3: GTTGTTGGGC ATCTTGCC 18 (2) INFORMATION FOR SEQ ID NO:4: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:4: GTACTTGCGG ATCTAGGC 18 WO 00/09525 PCT/US99/17712 EPI-109 267 (2) INFORMATION FOR SEQ ID NO:5: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:5: GTGGGCCTAG CTCTCGCC 18 (2) INFORMATION FOR SEQ ID NO:6: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:6: GTCGGGGTAC CTGTCGGC 18 (2) INFORMATION FOR SEQ ID NO:7: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 21 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:7: CTCGTCGCCG TCGCCGGCGG G 21 (2) INFORMATION FOR SEQ ID NO:8: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 20 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:8: GGGTGGTGCT ATTGTCGGGC 20 (2) INFORMATION FOR SEQ ID NO:9: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:9: GGCCCAGGGC CAGCC 15 (2) INFORMATION FOR SEQ ID NO:10: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 21 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear ' (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:10: GGCCGGGCCA GCCGGGCCCG G 21 (2) INFORMATION FOR SEQ ID NO:11: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 50 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:ll: GCGGCCTGGA AAGCTGAGAT GGAGGGCGGC ATGGCGGGCA CAGGCTGGGC 50 (2) INFORMATION FOR SEQ ID NO:12: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 49 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single WO 00/09525 PCT/US99/17712 EPI-109 268 (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:12: CGGCCTGGAA AGCTGAGATG GAGGGCGGCA TGGCGGGCAC AGGCTGGGC 49 (2) INFORMATION FOR SEQ ID NO:13: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 48 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:13: GGCCTGGAAA GCTGAGATGG AGGGCGGCAT GGCGGGCACA GGCTGGGC 48 (2) INFORMATION FOR SEQ ID NO:14: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 47 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:14: GCCTGGAAAG CTGAGATGGA GGGCGGCATG GCGGGCACAG GCTGGGC 47 (2) INFORMATION FOR SEQ ID NO:15: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 46 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:15: CCTGGAAAGC TGAGATGGAG GGCGGCATGG CGGGCACAGG CTGGGC 46 (2) INFORMATION FOR SEQ ID NO:16: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 45 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:16: CTGGAAAGCT GAGATGGAGG GCGGCATGGC GGGCACAGGC TGGGC 45 (2) INFORMATION FOR SEQ ID NO:17: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 44 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:17: TGGAAAGCTG AGATGGAGGG CGGCATGGCG GGCACAGGCT GGGC 44 (2) INFORMATION FOR SEQ ID NO:18: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 43 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:18: GGAAAGCTGA GATGGAGGGC GGCATGGCGG GCACAGGCTG GGC 43 .(2) INFORMATION FOR SEQ ID NO:19: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 42 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:19: GAAAGCTGAG ATGGAGGGCG GCATGGCGGG CACAGGCTGG GC 42 WO 00/09525 PCT/US99/17712 EPI-109 269 (2) INFORMATION FOR SEQ ID NO:20: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 41 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:20: AAAGCTGAGA TGGAGGGCGG CATGGCGGGC ACAGGCTGGG C 41 (2) INFORMATION FOR SEQ ID NO:21: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 40 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:21: AAGCTGAGAT GGAGGGCGGC ATGGCGGGCA CAGGCTGGGC 40 (2) INFORMATION FOR SEQ ID NO:22: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 39 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:22: AGCTGAGATG GAGGGCGGCA TGGCGGGCAC AGGCTGGGC 39 (2) INFORMATION FOR SEQ ID NO:23: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 38 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:23: GCTGAGATGG AGGGCGGCAT GGCGGGCACA GGCTGGGC 38 (2) INFORMATION FOR SEQ ID NO:24: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 37 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear ' (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:24: CTGAGATGGA GGGCGGCATG GCGGGCACAG GCTGGGC 37 (2) INFORMATION FOR SEQ ID NO:25: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 36 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:25: TGAGATGGAG GGCGGCATGG CGGGCACAGG CTGGGC 36 (2) INFORMATION FOR SEQ ID NO:26: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 35 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:26: GAGATGGAGG GCGGCATGGC GGGCACAGGC TGGGC 35 (2) INFORMATION FOR SEQ ID NO:27: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 34 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single WO 00/09525 PCT/US99/17712 EPI-109 270 (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:27: AGATGGAGGG CGGCATGGCG GGCACAGGCT GGGC 34 (2) INFORMATION FOR SEQ ID NO:28: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 33 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:28: GATGGAGGGC GGCATGGCGG GCACAGGCTG GGC 33 (2) INFORMATION FOR SEQ ID NO:29: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 32 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:29: ATGGAGGGCG GCATGGCGGG CACAGGCTGG GC 32 (2) INFORMATION FOR SEQ ID NO:30: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 31 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:30: TGGAGGGCGG CATGGCGGGC ACAGGCTGGG C 31 (2) INFORMATION FOR SEQ ID NO:31: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 30 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:31: GGAGGGCGGC ATGGCGGGCA CAGGCTGGGC 30 (2) INFORMATION FOR SEQ ID NO:32: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 29 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:32: GAGGGCGGCA TGGCGGGCAC AGGCTGGGC 29 (2) INFORMATION FOR SEQ ID NO:33: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 28 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:33: AGGGCGGCAT GGCGGGCACA GGCTGGGC 28 (2) INFORMATION FOR SEQ ID NO:34: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 27 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:34: GGGCGGCATG GCGGGCACAG GCTGGGC 27 WO 00/09525 PCT/US99/17712 EPI-109 271 (2) INFORMATION FOR SEQ ID NO:35: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 26 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear * (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:35: GGCGGCATGG CGGGCACAGG CTGGGC 26 (2) INFORMATION FOR SEQ ID NO:36: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 25 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:36: GCGGCATGGC GGGCACAGGC TGGGC 25 (2) INFORMATION FOR SEQ ID NO:37: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 24 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:37: CGGCATGGCG GGCACAGGCT GGGC 24 (2) INFORMATION FOR SEQ ID NO:38: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 23 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:38: GGCATGGCGG GCACAGGCTG GGC 23 (2) INFORMATION FOR SEQ ID NO:39: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:39: GCATGGCGGG CACAGGCTGG GC 22 (2) INFORMATION FOR SEQ ID NO:40: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 21 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:40: CATGGCGGGC ACAGGCTGGG C 21 (2) INFORMATION FOR SEQ ID NO:41: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 20 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:41: ATGGCGGGCA CAGGCTGGGC 20 (2) INFORMATION FOR SEQ ID NO:42: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 base pairs (B) TYPE: nucleic acid WO 00/09525 PCTIUS99/17712 EPI-109 272 (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:42: TGGCGGGCAC AGGCTGGGC 19 (2) INFORMATION FOR SEQ ID NO:43: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:43: GGCGGGCACA GGCTGGGC 18 (2) INFORMATION FOR SEQ ID NO:44: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 17 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:44: GCGGGCACAG GCTGGGC 17 (2) INFORMATION FOR SEQ ID NO:45: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 16 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:45: CGGGCACAGG CTGGGC 16 (2) INFORMATION FOR SEQ ID NO:46: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:46: GGGCACAGGC TGGGC 15 (2) INFORMATION FOR SEQ ID NO:47: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:47: GGCACAGGCT GGGC 14 (2) INFORMATION FOR SEQ ID NO:48: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 13 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:48: GCACAGGCTG GGC 13 (2) INFORMATION FOR SEQ ID NO:49: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 12 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:49: CACAGGCTGG GC 12 WO 00/09525 PCT/US99/17712 EPI-109 273 (2) INFORMATION FOR SEQ ID NO:50: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 11 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:50: ACAGGCTGGG C 11 (2) INFORMATION FOR SEQ ID NO:51: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 10 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:51: CAGGCTGGGC 10 (2) INFORMATION FOR SEQ ID NO:52: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 9 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:52: AGGCTGGGC 9 (2) INFORMATION FOR SEQ ID NO:53: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 51 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:53: GGCGGCCTGG AAAGCTGAGA TGGAGGGCGG CATGGCGGGC ACAGGCTGGG C 51 (2) INFORMATION FOR SEQ ID NO:54: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 50 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:54: GGCGGCCTGG AAAGCTGAGA TGGAGGGCGG CATGGCGGGC ACAGGCTGGG 50 (2) INFORMATION FOR SEQ ID NO:55: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 49 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:55: GGCGGCCTGG AAAGCTGAGA TGGAGGGCGG CATGGCGGGC ACAGGCTGG 49 (2) INFORMATION FOR SEQ ID NO:56: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 48 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:56: GGCGGCCTGG AAAGCTGAGA TGGAGGGCGG CATGGCGGGC ACAGGCTG 48 (2) INFORMATION FOR SEQ ID NO:57: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 47 base pairs (B) TYPE: nucleic acid WO 00/09525 PCT/US99/17712 EPI-109 274 (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:57: GGCGGCCTGG AAAGCTGAGA TGGAGGGCGG CATGGCGGGC ACAGGCT 47 (2) INFORMATION FOR SEQ ID NO:58: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 46 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:58: GGCGGCCTGG AAAGCTGAGA TGGAGGGCGG CATGGCGGGC ACAGGC 46 (2) INFORMATION FOR SEQ ID NO:59: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 45 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:59: GGCGGCCTGG AAAGCTGAGA TGGAGGGCGG CATGGCGGGC ACAGG 45 (2) INFORMATION FOR SEQ ID NO:60: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 44 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:60: GGCGGCCTGG AAAGCTGAGA TGGAGGGCGG CATGGCGGGC ACAG 44 (2) INFORMATION FOR SEQ ID NO:61: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 43 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:61: GGCGGCCTGG AAAGCTGAGA TGGAGGGCGG CATGGCGGGC ACA 43 (2) INFORMATION FOR SEQ ID NO:62: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 42 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:62: GGCGGCCTGG AAAGCTGAGA TGGAGGGCGG CATGGCGGGC AC 42 (2) INFORMATION FOR SEQ ID NO:63: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 41 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:63: GGCGGCCTGG AAAGCTGAGA TGGAGGGCGG CATGGCGGGC A 41 (2) INFORMATION FOR SEQ ID NO:64: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 40 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:64: GGCGGCCTGG AAAGCTGAGA TGGAGGGCGG CATGGCGGGC 40 WO 00/09525 PCT/US99/17712 EPI-109 275 (2) INFORMATION FOR SEQ ID NO:65: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 39 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:65: GGCGGCCTGG AAAGCTGAGA TGGAGGGCGG CATGGCGGG 39 (2) INFORMATION FOR SEQ ID NO:66: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 38 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:66: GGCGGCCTGG AAAGCTGAGA TGGAGGGCGG CATGGCGG 38 (2) INFORMATION FOR SEQ ID NO:67: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 37 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:67: GGCGGCCTGG AAAGCTGAGA TGGAGGGCGG CATGGCG 37 (2) INFORMATION FOR SEQ ID NO:68: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 36 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:68: GGCGGCCTGG AAAGCTGAGA TGGAGGGCGG CATGGC 36 (2) INFORMATION FOR SEQ ID NO:69: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 35 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:69: GGCGGCCTGG AAAGCTGAGA TGGAGGGCGG CATGG 35 (2) INFORMATION FOR SEQ ID NO:70: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 34 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:70: GGCGGCCTGG AAAGCTGAGA TGGAGGGCGG CATG 34 (2) INFORMATION FOR SEQ ID NO:71: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 33 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:71: GGCGGCCTGG AAAGCTGAGA TGGAGGGCGG CAT 33 (2) INFORMATION FOR SEQ ID NO:72: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 32 base pairs (B) TYPE: nucleic acid WO 00/09525 PCTIUS99/17712 EPI-109 276 (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:72: GGCGGCCTGG AAAGCTGAGA TGGAGGGCGG CA 32 (2) INFORMATION FOR SEQ ID NO:73: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 31 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:73: GGCGGCCTGG AAAGCTGAGA TGGAGGGCGG C 31 (2) INFORMATION FOR SEQ ID NO:74: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 30 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:74: GGCGGCCTGG AAAGCTGAGA TGGAGGGCGG 30 (2) INFORMATION FOR SEQ ID NO:75: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 29 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:75: GGCGGCCTGG AAAGCTGAGA TGGAGGGCG 29 (2) INFORMATION FOR SEQ ID NO:76: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 28 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:76: GGCGGCCTGG AAAGCTGAGA TGGAGGGC 28 (2) INFORMATION FOR SEQ ID NO:77: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 27 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:77: GGCGGCCTGG AAAGCTGAGA TGGAGGG 27 (2) INFORMATION FOR SEQ ID NO:78: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 26 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:78: GGCGGCCTGG AAAGCTGAGA TGGAGG 26 (2) INFORMATION FOR SEQ ID NO:79: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 25 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:79: GGCGGCCTGG AAAGCTGAGA TGGAG 25 WO 00/09525 PCT/US99/17712 EPI-109 277 (2) INFORMATION FOR SEQ ID NO:80: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 24 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:80: GGCGGCCTGG AAAGCTGAGA TGGA 24 (2) INFORMATION FOR SEQ ID NO:81: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 23 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:81: GGCGGCCTGG AAAGCTGAGA TGG 23 (2) INFORMATION FOR SEQ ID NO:82: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:82: GGCGGCCTGG AAAGCTGAGA TG 22 (2) INFORMATION FOR SEQ ID NO:83: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 21 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:83: GGCGGCCTGG AAAGCTGAGA T 21 (2) INFORMATION FOR SEQ ID NO:84: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 20 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:84: GGCGGCCTGG AAAGCTGAGA 20 (2) INFORMATION FOR SEQ ID NO:85: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:85: GGCGGCCTGG AAAGCTGAG 19 (2) INFORMATION FOR SEQ ID NO:86: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:86: GGCGGCCTGG AAAGCTGA 18 (2) INFORMATION FOR SEQ ID NO:87: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 17 base pairs (B) TYPE: nucleic acid WO 00/09525 PCT/US99/17742 EPI-109 278 (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:87: GGCGGCCTGG AAAGCTG 17 (2) INFORMATION FOR SEQ ID NO:88: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 16 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:88: GGCGGCCTGG AAAGCT 16 (2) INFORMATION FOR SEQ ID NO:89: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:89: GGCGGCCTGG AAAGC 15 (2) INFORMATION FOR SEQ ID NO:90: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:90: GGCGGCCTGG AAAG 14 (2) INFORMATION FOR SEQ ID NO:91: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 13 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:91: GGCGGCCTGG AAA 13 (2) INFORMATION FOR SEQ ID NO:92: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 12 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:92: GGCGGCCTGG AA 12 (2) INFORMATION FOR SEQ ID NO:93: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 11 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:93: GGCGGCCTGG A 11 (2) INFORMATION FOR SEQ ID NO:94: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 10 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:94: GGCGGCCTGG 10 WO 00/09525 PCTIUS99/17712 EPI-109 279 (2) INFORMATION FOR SEQ ID NO:95: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 50 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:95: GCGGCCTGGA AAGCTGAGAT GGAGGGCGGC ATGGCGGGCA CAGGCTGGGC 50 (2) INFORMATION FOR SEQ ID NO:96: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 49 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:96: GCGGCCTGGA AAGCTGAGAT GGAGGGCGGC ATGGCGGGCA CAGGCTGGG 49 (2) INFORMATION FOR SEQ ID NO:97: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 48 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:97: GCGGCCTGGA AAGCTGAGAT GGAGGGCGGC ATGGCGGGCA CAGGCTGG 48 (2) INFORMATION FOR SEQ ID NO:98: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 47 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:98: GCGGCCTGGA AAGCTGAGAT GGAGGGCGGC ATGGCGGGCA CAGGCTG 47 (2) INFORMATION FOR SEQ ID NO:99: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 46 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:99: GCGGCCTGGA AAGCTGAGAT GGAGGGCGGC ATGGCGGGCA CAGGCT 46 (2) INFORMATION FOR SEQ ID NO:100: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 45 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:100: GCGGCCTGGA AAGCTGAGAT GGAGGGCGGC ATGGCGGGCA CAGGC 45 (2) INFORMATION FOR SEQ ID NO:101: Ci) SEQUENCE CHARACTERISTICS: (A) LENGTH: 44 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:101: GCGGCCTGGA AAGCTGAGAT GGAGGGCGGC ATGGCGGGCA CAGG 44 (2) INFORMATION FOR SEQ ID NO:102: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 43 base pairs (B) TYPE: nucleic acid WO 00/09525 PCTIUS99/17712 EPI-109 280 (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:102: GCGGCCTGGA AAGCTGAGAT GGAGGGCGGC ATGGCGGGCA CAG 43 (2) INFORMATION FOR SEQ ID NO:103: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 42 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:103: GCGGCCTGGA AAGCTGAGAT GGAGGGCGGC ATGGCGGGCA CA 42 (2) INFORMATION FOR SEQ ID NO:104: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 41 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:104: GCGGCCTGGA AAGCTGAGAT GGAGGGCGGC ATGGCGGGCA C 41 (2) INFORMATION FOR SEQ ID NO:105: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 40 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:105: GCGGCCTGGA AAGCTGAGAT GGAGGGCGGC ATGGCGGGCA 40 (2) INFORMATION FOR SEQ ID NO:106: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 39 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:106: GCGGCCTGGA AAGCTGAGAT GGAGGGCGGC ATGGCGGGC 39 (2) INFORMATION FOR SEQ ID NO:107: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 38 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:107: GCGGCCTGGA AAGCTGAGAT GGAGGGCGGC ATGGCGGG 38 (2) INFORMATION FOR SEQ ID NO:108: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 37 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:108: GCGGCCTGGA AAGCTGAGAT GGAGGGCGGC ATGGCGG 37 (2) INFORMATION FOR SEQ ID NO:109: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 36 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:109: GCGGCCTGGA AAGCTGAGAT GGAGGGCGGC ATGGCG 36 WO 00/09525 PCT/US99/17712 EPI-109 281 (2) INFORMATION FOR SEQ ID NO:110: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 35 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:ll0: GCGGCCTGGA AAGCTGAGAT GGAGGGCGGC ATGGC 35 (2) INFORMATION FOR SEQ ID NO:111: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 34 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:111: GCGGCCTGGA AAGCTGAGAT GGAGGGCGGC ATGG 34 (2) INFORMATION FOR SEQ ID NO:112: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 33 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:112: GCGGCCTGGA AAGCTGAGAT GGAGGGCGGC ATG 33 (2) INFORMATION FOR SEQ ID NO:113: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 32 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:113: GCGGCCTGGA AAGCTGAGAT GGAGGGCGGC AT 32 (2) INFORMATION FOR SEQ ID NO:114: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 31 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:114: GCGGCCTGGA AAGCTGAGAT GGAGGGCGGC A 31 (2) INFORMATION FOR SEQ ID NO:115: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 30 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:115: GCGGCCTGGA AAGCTGAGAT GGAGGGCGGC 30 (2) INFORMATION FOR SEQ ID NO:116: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 29 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:116: GCGGCCTGGA AAGCTGAGAT GGAGGGCGG 29 (2) INFORMATION FOR SEQ ID NO:117: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 28 base pairs (B) TYPE: nucleic acid WO 00/09525 PCT/US99/17712 EPI-109 282 (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:117: GCGGCCTGGA AAGCTGAGAT GGAGGGCG 28 (2) INFORMATION FOR SEQ ID NO:118: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 27 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:ll8: GCGGCCTGGA AAGCTGAGAT GGAGGGC 27 (2) INFORMATION FOR SEQ ID NO:119: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 26 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:119: GCGGCCTGGA AAGCTGAGAT GGAGGG 26 (2) INFORMATION FOR SEQ ID NO:120: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 25 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:120: GCGGCCTGGA AAGCTGAGAT GGAGG 25 (2) INFORMATION FOR SEQ ID NO:121: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 24 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:121: GCGGCCTGGA AAGCTGAGAT GGAG 24 (2) INFORMATION FOR SEQ ID NO:122: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 23 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:122: GCGGCCTGGA AAGCTGAGAT GGA 23 (2) INFORMATION FOR SEQ ID NO:123: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:123: GCGGCCTGGA AAGCTGAGAT GG 22 (2) INFORMATION FOR SEQ ID NO:124: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 21 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:124: GCGGCCTGGA AAGCTGAGAT G 21 WO 00/09525 PCT/US99/17712 EPI-109 283 (2) INFORMATION FOR SEQ ID NO:125: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 20 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:125: GCGGCCTGGA AAGCTGAGAT 20 (2) INFORMATION FOR SEQ ID NO:126: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:126: GCGGCCTGGA AAGCTGAGA 19 (2) INFORMATION FOR SEQ ID NO:127: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:127: GCGGCCTGGA AAGCTGAG 18 (2) INFORMATION FOR SEQ ID NO:128: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 17 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:128: GCGGCCTGGA AAGCTGA 17 (2) INFORMATION FOR SEQ ID NO:129: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 16 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:129: GCGGCCTGGA AAGCTG 16 (2) INFORMATION FOR SEQ ID NO:130: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:130: GCGGCCTGGA AAGCT 15 (2) INFORMATION FOR SEQ ID NO:131: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid .(C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:131: GCGGCCTGGA AAGC 14 (2) INFORMATION FOR SEQ ID NO:132: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 13 base pairs (B) TYPE: nucleic acid WO 00/09525 PCT/US99/17712 EPI-109 284 (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:132: GCGGCCTGGA AAG 13 (2) INFORMATION FOR SEQ ID NO:133: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 12 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:133: GCGGCCTGGA AA 12 (2) INFORMATION FOR SEQ ID NO:134: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 11 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:134: GCGGCCTGGA A 11 (2) INFORMATION FOR SEQ ID NO:135: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 10 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:135: GCGGCCTGGA 10 (2) INFORMATION FOR SEQ ID NO:136: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 49 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:136: CGGCCTGGAA AGCTGAGATG GAGGGCGGCA TGGCGGGCAC AGGCTGGGC 49 (2) INFORMATION FOR SEQ ID NO:137: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 48 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:137: CGGCCTGGAA AGCTGAGATG GAGGGCGGCA TGGCGGGCAC AGGCTGGG 48 (2) INFORMATION FOR SEQ ID NO:138: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 47 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:138: CGGCCTGGAA AGCTGAGATG GAGGGCGGCA TGGCGGGCAC AGGCTGG 47 (2) INFORMATION FOR SEQ ID NO:139: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 46 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:139: CGGCCTGGAA AGCTGAGATG GAGGGCGGCA TGGCGGGCAC AGGCTG 46 WO 00/09525 PCT/US99/17712 EPI-109 285 (2) INFORMATION FOR SEQ ID NO:140: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 45 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:140: CGGCCTGGAA AGCTGAGATG GAGGGCGGCA TGGCGGGCAC AGGCT 45 (2) INFORMATION FOR SEQ ID NO:141: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 44 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:141: CGGCCTGGAA AGCTGAGATG GAGGGCGGCA TGGCGGGCAC AGGC 44 (2) INFORMATION FOR SEQ ID NO:142: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 43 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:142: CGGCCTGGAA AGCTGAGATG GAGGGCGGCA TGGCGGGCAC AGG 43 (2) INFORMATION FOR SEQ ID NO:143: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 42 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:143: CGGCCTGGAA AGCTGAGATG GAGGGCGGCA TGGCGGGCAC AG 42 (2) INFORMATION FOR SEQ ID NO:144: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 41 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:144: CGGCCTGGAA AGCTGAGATG GAGGGCGGCA TGGCGGGCAC A 41 (2) INFORMATION FOR SEQ ID NO:145: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 40 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:145: CGGCCTGGAA AGCTGAGATG GAGGGCGGCA TGGCGGGCAC 40 (2) INFORMATION FOR SEQ ID NO:146: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 39 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:146: CGGCCTGGAA AGCTGAGATG GAGGGCGGCA TGGCGGGCA 39 (2) INFORMATION FOR SEQ ID NO:147: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 38 base pairs (B) TYPE: nucleic acid WO 00/09525 PCT/US99/17712 EPI-109 286 (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:147: CGGCCTGGAA AGCTGAGATG GAGGGCGGCA TGGCGGGC 38 (2) INFORMATION FOR SEQ ID NO:148: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 37 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:148: CGGCCTGGAA AGCTGAGATG GAGGGCGGCA TGGCGGG 37 (2) INFORMATION FOR SEQ ID NO:149: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 36 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:149: CGGCCTGGAA AGCTGAGATG GAGGGCGGCA TGGCGG 36 (2) INFORMATION FOR SEQ ID NO:150: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 35 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:150: CGGCCTGGAA AGCTGAGATG GAGGGCGGCA TGGCG 35 (2) INFORMATION FOR SEQ ID NO:151: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 34 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:151: CGGCCTGGAA AGCTGAGATG GAGGGCGGCA TGGC 34 (2) INFORMATION FOR SEQ ID NO:152: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 33 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:152: CGGCCTGGAA AGCTGAGATG GAGGGCGGCA TGG 33 (2) INFORMATION FOR SEQ ID NO:153: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 32 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:153: CGGCCTGGAA AGCTGAGATG GAGGGCGGCA TG 32 (2) INFORMATION FOR SEQ ID NO:154: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 31 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:154: CGGCCTGGAA AGCTGAGATG GAGGGCGGCA T 31 WO 00/09525 PCT/US99/17712 EPI-109 287 (2) INFORMATION FOR SEQ ID NO:155: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 30 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:155: CGGCCTGGAA AGCTGAGATG GAGGGCGGCA 30 (2) INFORMATION FOR SEQ ID NO:156: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 29 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:156: CGGCCTGGAA AGCTGAGATG GAGGGCGGC 29 (2) INFORMATION FOR SEQ ID NO:157: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 28 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:157: CGGCCTGGAA AGCTGAGATG GAGGGCGG 28 (2) INFORMATION FOR SEQ ID NO:158: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 27 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:158: CGGCCTGGAA AGCTGAGATG GAGGGCG 27 (2) INFORMATION FOR SEQ ID NO:159: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 26 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:159: CGGCCTGGAA AGCTGAGATG GAGGGC 26 (2) INFORMATION FOR SEQ ID NO:160: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 25 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:160: CGGCCTGGAA AGCTGAGATG GAGGG 25 (2) INFORMATION FOR SEQ ID NO:161: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 24 base pairs (B) TYPE: nucleic acid .(C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:161: CGGCCTGGAA AGCTGAGATG GAGG 24 (2) INFORMATION FOR SEQ ID NO:162: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 23 base pairs (B) TYPE: nucleic acid WO 00/09525 PCT/US99/17712 EPI-109 288 (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:162: CGGCCTGGAA AGCTGAGATG GAG 23 (2) INFORMATION FOR SEQ ID NO:163: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:163: CGGCCTGGAA AGCTGAGATG GA 22 (2) INFORMATION FOR SEQ ID NO:164: (i) SEQUENCE CHARACTERISTICS: CA) LENGTH: 21 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:164: CGGCCTGGAA AGCTGAGATG G 21 (2) INFORMATION FOR SEQ ID NO:165: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 20 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:165: CGGCCTGGAA AGCTGAGATG 20 (2) INFORMATION FOR SEQ ID NO:166: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:166: CGGCCTGGAA AGCTGAGAT 19 (2) INFORMATION FOR SEQ ID NO:167: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:167: CGGCCTGGAA AGCTGAGA 18 (2) INFORMATION FOR SEQ ID NO:168: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 17 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:168: CGGCCTGGAA AGCTGAG 17 (2) INFORMATION FOR SEQ ID NO:169: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 16 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:169: CGGCCTGGAA AGCTGA 16 WO 00/09525 PCT/US99/17712 EPI-109 289 (2) INFORMATION FOR SEQ ID NO:170: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:170: CGGCCTGGAA AGCTG 15 (2) INFORMATION FOR SEQ ID NO:171: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear. (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:171: CGGCCTGGAA AGCT 14 (2) INFORMATION FOR SEQ ID NO:172: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 13 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:172: CGGCCTGGAA AGC 13 (2) INFORMATION FOR SEQ ID NO:173: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 12 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:173: CGGCCTGGAA AG 12 (2) INFORMATION FOR SEQ ID NO:174: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 11 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:174: CGGCCTGGAA A 11 (2) INFORMATION FOR SEQ ID NO:175: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 10 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:175: CGGCCTGGAA 10 (2) INFORMATION FOR SEQ ID NO:176: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 48 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:176: GGCCTGGAAA GCTGAGATGG AGGGCGGCAT GGCGGGCACA GGCTGGGC 48 (2) INFORMATION FOR SEQ ID NO:177: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 47 base pairs (B) TYPE: nucleic acid WO 00/09525 PCTIUS99/17712 EPI-109 290 (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:177: GGCCTGGAAA GCTGAGATGG AGGGCGGCAT GGCGGGCACA GGCTGGG 47 (2) INFORMATION FOR SEQ ID NO:178: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 46 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:178: GGCCTGGAAA GCTGAGATGG AGGGCGGCAT GGCGGGCACA GGCTGG 46 (2) INFORMATION FOR SEQ ID NO:179: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 45 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:179: GGCCTGGAAA GCTGAGATGG AGGGCGGCAT GGCGGGCACA GGCTG 45 (2) INFORMATION FOR SEQ ID NO:180: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 44 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:180: GGCCTGGAAA GCTGAGATGG AGGGCGGCAT GGCGGGCACA GGCT 44 (2) INFORMATION FOR SEQ ID NO:181: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 43 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:181: GGCCTGGAAA GCTGAGATGG AGGGCGGCAT GGCGGGCACA GGC 43 (2) INFORMATION FOR SEQ ID NO:182: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 42 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:182: GGCCTGGAAA GCTGAGATGG AGGGCGGCAT GGCGGGCACA GG 42 (2) INFORMATION FOR SEQ ID NO:183: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 41 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:183: GGCCTGGAAA GCTGAGATGG AGGGCGGCAT GGCGGGCACA G 41 (2) INFORMATION FOR SEQ ID NO:184: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 40 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:184: GGCCTGGAAA GCTGAGATGG AGGGCGGCAT GGCGGGCACA 40 WO 00/09525 PCTIUS99/177-12 EPI-109 291 (2) INFORMATION FOR SEQ ID NO:185: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 39 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:185: GGCCTGGAAA GCTGAGATGG AGGGCGGCAT GGCGGGCAC 39 (2) INFORMATION FOR SEQ ID NO:186: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 38 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:186: GGCCTGGAAA GCTGAGATGG AGGGCGGCAT GGCGGGCA 38 (2) INFORMATION FOR SEQ ID NO:187: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 37 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:187: GGCCTGGAAA GCTGAGATGG AGGGCGGCAT GGCGGGC 37 (2) INFORMATION FOR SEQ ID NO:188: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 36 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:188: GGCCTGGAAA GCTGAGATGG AGGGCGGCAT GGCGGG 36 (2) INFORMATION FOR SEQ ID NO:189: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 35 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:189: GGCCTGGAAA GCTGAGATGG AGGGCGGCAT GGCGG 35 (2) INFORMATION FOR SEQ ID NO:190: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 34 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:190: GGCCTGGAAA GCTGAGATGG AGGGCGGCAT GGCG 34 (2) INFORMATION FOR BEQ ID NO:191: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 33 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:191: GGCCTGGAAA GCTGAGATGG AGGGCGGCAT GGC 33 (2) INFORMATION FOR SEQ ID NO:192: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 32 base pairs (B) TYPE: nucleic acid WO 00/09525 PCT/US99/17712 EPI-109 292 (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:192: GGCCTGGAAA GCTGAGATGG AGGGCGGCAT GG 32 (2) INFORMATION FOR SEQ ID NO:193: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 31 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:193: GGCCTGGAAA GCTGAGATGG AGGGCGGCAT G 31 (2) INFORMATION FOR SEQ ID NO:194: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 30 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:194: GGCCTGGAAA GCTGAGATGG AGGGCGGCAT 30 (2) INFORMATION FOR SEQ ID NO:195: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 29 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:195: GGCCTGGAAA GCTGAGATGG AGGGCGGCA 29 (2) INFORMATION FOR SEQ ID NO:196: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 28 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:196: GGCCTGGAAA GCTGAGATGG AGGGCGGC 28 (2) INFORMATION FOR SEQ ID NO:197: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 27 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:197: GGCCTGGAAA GCTGAGATGG AGGGCGG 27 (2) INFORMATION FOR SEQ ID NO:198: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 26 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:198: GGCCTGGAAA GCTGAGATGG AGGGCG 26 (2) INFORMATION FOR SEQ ID NO:199: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 25 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:199: GGCCTGGAAA GCTGAGATGG AGGGC 25 WO 00/09525 PCT/US99/17712 EPI-109 293 (2) INFORMATION FOR SEQ ID NO:200: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 24 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:200: GGCCTGGAAA GCTGAGATGG AGGG 24 (2) INFORMATION FOR SEQ ID NO:201: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 23 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:201: GGCCTGGAAA GCTGAGATGG AGG 23 (2) INFORMATION FOR SEQ ID NO:202: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:202: GGCCTGGAAA GCTGAGATGG AG 22 (2) INFORMATION FOR SEQ ID NO:203: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 21 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:203: GGCCTGGAAA GCTGAGATGG A 21 (2) INFORMATION FOR SEQ ID NO:204: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 20 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:204: GGCCTGGAAA GCTGAGATGG 20 (2) INFORMATION FOR SEQ ID NO:205: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:205: GGCCTGGAAA GCTGAGATG 19 (2) INFORMATION FOR SEQ ID NO:206: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:206: GGCCTGGAAA GCTGAGAT 18 (2) INFORMATION FOR SEQ ID NO:207: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 17 base pairs (B) TYPE: nucleic acid WO 00/09525 PCT/US99/17712 EPI-109 294 (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:207: GGCCTGGAAA GCTGAGA 17 (2) INFORMATION FOR SEQ ID NO:208: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 16 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:208: GGCCTGGAAA GCTGAG 16 (2) INFORMATION FOR SEQ ID NO:209: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:209: GGCCTGGAAA GCTGA 15 (2) INFORMATION FOR SEQ ID NO:210: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:210: GGCCTGGAAA GCTG 14 (2) INFORMATION FOR SEQ ID NO:211: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 13 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:211: GGCCTGGAAA GCT 13 (2) INFORMATION FOR SEQ ID NO:212: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 12 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:212: GGCCTGGAAA GC 12 (2) INFORMATION FOR SEQ ID NO:213: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 11 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:213: GGCCTGGAAA G 11 (2) INFORMATION FOR SEQ ID NO:214: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 10 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:214: GGCCTGGAAA 10 WO 00/09525 PCT/US99/17712 EPI-109 295 (2) INFORMATION FOR SEQ ID NO:215: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 47 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:215: GCCTGGAAAG CTGAGATGGA GGGCGGCATG GCGGGCACAG GCTGGGC 47 (2) INFORMATION FOR SEQ ID NO:216: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 46 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:216: GCCTGGAAAG CTGAGATGGA GGGCGGCATG GCGGGCACAG GCTGGG 46 (2) INFORMATION FOR SEQ ID NO:217: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 45 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:217: GCCTGGAAAG CTGAGATGGA GGGCGGCATG GCGGGCACAG GCTGG 45 (2) INFORMATION FOR SEQ ID NO:218: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 44 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:218: GCCTGGAAAG CTGAGATGGA GGGCGGCATG GCGGGCACAG GCTG 44 (2) INFORMATION FOR SEQ ID NO:219: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 43 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:219: GCCTGGAAAG CTGAGATGGA GGGCGGCATG GCGGGCACAG GCT 43 (2) INFORMATION FOR SEQ ID NO:220: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 42 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:220: GCCTGGAAAG CTGAGATGGA GGGCGGCATG GCGGGCACAG GC 42 (2) INFORMATION FOR SEQ ID NO:221: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 41 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:221: GCCTGGAAAG CTGAGATGGA GGGCGGCATG GCGGGCACAG G 41 (2) INFORMATION FOR SEQ ID NO:222: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 40 base pairs (B) TYPE: nucleic acid WO 00/09525 PCT/US99/17712 EPI-109 296 (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:222: GCCTGGAAAG CTGAGATGGA GGGCGGCATG GCGGGCACAG 40 (2) INFORMATION FOR SEQ ID NO:223: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 39 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:223: GCCTGGAAAG CTGAGATGGA GGGCGGCATG GCGGGCACA 39 (2) INFORMATION FOR SEQ ID NO:224: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 38 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:224: GCCTGGAAAG CTGAGATGGA GGGCGGCATG GCGGGCAC 38 (2) INFORMATION FOR SEQ ID NO:225: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 37 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:225: GCCTGGAAAG CTGAGATGGA GGGCGGCATG GCGGGCA 37 (2) INFORMATION FOR SEQ ID NO:226: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 36 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:226: GCCTGGAAAG CTGAGATGGA GGGCGGCATG GCGGGC 36 (2) INFORMATION FOR SEQ ID NO:227: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 35 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:227: GCCTGGAAAG CTGAGATGGA GGGCGGCATG GCGGG 35 (2) INFORMATION FOR SEQ ID NO:228: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 34 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:228: GCCTGGAAAG CTGAGATGGA GGGCGGCATG GCGG 34 (2) INFORMATION FOR SEQ ID NO:229: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 33 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:229: GCCTGGAAAG CTGAGATGGA GGGCGGCATG GCG 33 WO 00/09525 PCT/US99/17712 EPI-109 297 (2) INFORMATION FOR SEQ ID NO:230: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 32 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:230: GCCTGGAAAG CTGAGATGGA GGGCGGCATG GC 32 (2) INFORMATION FOR SEQ ID NO:231: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 31 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:231: GCCTGGAAAG CTGAGATGGA GGGCGGCATG G 31 (2) INFORMATION FOR SEQ ID NO:232: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 30 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:232: GCCTGGAAAG CTGAGATGGA GGGCGGCATG 30 (2) INFORMATION FOR SEQ ID NO:233: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 29 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:233: GCCTGGAAAG CTGAGATGGA GGGCGGCAT 29 (2) INFORMATION FOR SEQ ID NO:234: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 28 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:234: GCCTGGAAAG CTGAGATGGA GGGCGGCA 28 (2) INFORMATION FOR SEQ ID NO:235: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 27 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:235: GCCTGGAAAG CTGAGATGGA GGGCGGC 27 (2) INFORMATION FOR SEQ ID NO:236: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 26 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:236: GCCTGGAAAG CTGAGATGGA GGGCGG 26 (2) INFORMATION FOR SEQ ID NO:237: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 25 base pairs (B) TYPE: nucleic acid WO 00/09525 PCT/US99/17712 EPI-109 298 (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:237: GCCTGGAAAG CTGAGATGGA GGGCG 25 (2) INFORMATION FOR SEQ ID NO:238: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 24 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:238: GCCTGGAAAG CTGAGATGGA GGGC 24 (2) INFORMATION FOR SEQ ID NO:239: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 23 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:239: GCCTGGAAAG CTGAGATGGA GGG 23 (2) INFORMATION FOR SEQ ID NO:240: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:240: GCCTGGAAAG CTGAGATGGA GG 22 (2) INFORMATION FOR SEQ ID NO:241: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 21 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:241: GCCTGGAAAG CTGAGATGGA G 21 (2) INFORMATION FOR SEQ ID NO:242: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 20 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:242: GCCTGGAAAG CTGAGATGGA 20 (2) INFORMATION FOR SEQ ID NO:243: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:243: GCCTGGAAAG CTGAGATGG 19 (2) INFORMATION FOR SEQ ID NO:244: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:244: GCCTGGAAAG CTGAGATG 18 WO 00/09525 PCT/US99/17712 EPI-109 299 (2) INFORMATION FOR SEQ ID NO:245: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 17 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:245: GCCTGGAAAG CTGAGAT 17 (2) INFORMATION FOR SEQ ID NO:246: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 16 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:246: GCCTGGAAAG CTGAGA 16 (2) INFORMATION FOR SEQ ID NO:247: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:247: GCCTGGAAAG CTGAG 15 (2) INFORMATION FOR SEQ ID NO:248: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:248: GCCTGGAAAG CTGA 14 (2) INFORMATION FOR SEQ ID NO:249: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 13 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:249: GCCTGGAAAG CTG 13 (2) INFORMATION FOR SEQ ID NO:250: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 12 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:250: GCCTGGAAAG CT 12 (2) INFORMATION FOR SEQ ID NO:251: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 11 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:251: GCCTGGAAAG C 11 (2) INFORMATION FOR SEQ ID NO:252: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 10 base pairs (B) TYPE: nucleic acid WO 00/09525 PCT/US99/17712 EPI-109 300 (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:252: GCCTGGAAAG 10 (2) INFORMATION FOR SEQ ID NO:253: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 46 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:253: CCTGGAAAGC TGAGATGGAG GGCGGCATGG CGGGCACAGG CTGGGC 46 (2) INFORMATION FOR SEQ ID NO:254: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 45 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:254: CCTGGAAAGC TGAGATGGAG GGCGGCATGG CGGGCACAGG CTGGG 45 (2) INFORMATION FOR SEQ ID NO:255: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 44 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:255: CCTGGAAAGC TGAGATGGAG GGCGGCATGG CGGGCACAGG CTGG 44 (2) INFORMATION FOR SEQ ID NO:256: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 43 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:256: CCTGGAAAGC TGAGATGGAG GGCGGCATGG CGGGCACAGG CTG 43 (2) INFORMATION FOR SEQ ID NO:257: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 42 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear ' (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:257: CCTGGAAAGC TGAGATGGAG GGCGGCATGG CGGGCACAGG CT 42 (2) INFORMATION FOR SEQ ID NO:258: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 41 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:258: CCTGGAAAGC TGAGATGGAG GGCGGCATGG CGGGCACAGG C 41 (2) INFORMATION FOR SEQ ID NO:259: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 40 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:259: CCTGGAAAGC TGAGATGGAG GGCGGCATGG CGGGCACAGG 40 WO 00/09525 PCT/US99/17712 EPI-109 301 (2) INFORMATION FOR SEQ ID NO:260: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 39 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:260: CCTGGAAAGC TGAGATGGAG GGCGGCATGG CGGGCACAG 39 (2) INFORMATION FOR SEQ ID NO:261: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 38 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:261: CCTGGAAAGC TGAGATGGAG GGCGGCATGG CGGGCACA 38 (2) INFORMATION FOR SEQ ID NO:262: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 37 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:262: CCTGGAAAGC TGAGATGGAG GGCGGCATGG CGGGCAC 37 (2) INFORMATION FOR SEQ ID NO:263: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 36 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:263: CCTGGAAAGC TGAGATGGAG GGCGGCATGG CGGGCA 36 (2) INFORMATION FOR SEQ ID NO:264: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 35 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:264: CCTGGAAAGC TGAGATGGAG GGCGGCATGG CGGGC 35 (2) INFORMATION FOR SEQ ID NO:265: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 34 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:265: CCTGGAAAGC TGAGATGGAG GGCGGCATGG CGGG 34 (2) INFORMATION FOR SEQ ID NO:266: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 33 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:266: CCTGGAAAGC TGAGATGGAG GGCGGCATGG CGG 33 (2) INFORMATION FOR SEQ ID NO:267: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 32 base pairs (B) TYPE: nucleic acid WO 00/09525 PCT/US99/17712 EPI-109 302 (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:267: CCTGGAAAGC TGAGATGGAG GGCGGCATGG CG 32 (2) INFORMATION FOR SEQ ID NO:268: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 31 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear ' (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:268: CCTGGAAAGC TGAGATGGAG GGCGGCATGG C 31 (2) INFORMATION FOR SEQ ID NO:269: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 30 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:269: CCTGGAAAGC TGAGATGGAG GGCGGCATGG 30 (2) INFORMATION FOR SEQ ID NO:270: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 29 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:270: CCTGGAAAGC TGAGATGGAG GGCGGCATG 29 (2) INFORMATION FOR SEQ ID NO:271: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 28 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:271: CCTGGAAAGC TGAGATGGAG GGCGGCAT 28 (2) INFORMATION FOR SEQ ID NO:272: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 27 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:272: CCTGGAAAGC TGAGATGGAG GGCGGCA 27 (2) INFORMATION FOR SEQ ID NO:273: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 26 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:273: CCTGGAAAGC TGAGATGGAG GGCGGC 26 (2) INFORMATION FOR SEQ ID NO:274: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 25 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:274: CCTGGAAAGC TGAGATGGAG GGCGG 25 WO 00/09525 PCTIUS99/17712 EPI-109 303 (2) INFORMATION FOR SEQ ID NO:275: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 24 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:275: CCTGGAAAGC TGAGATGGAG GGCG 24 (2) INFORMATION FOR SEQ ID NO:276: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 23 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:276: CCTGGAAAGC TGAGATGGAG GGC 23 (2) INFORMATION FOR SEQ ID NO:277: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:277: CCTGGAAAGC TGAGATGGAG GG 22 (2) INFORMATION FOR SEQ ID NO:278: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 21 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:278: CCTGGAAAGC TGAGATGGAG G 21 (2) INFORMATION FOR SEQ ID NO:279: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 20 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:279: CCTGGAAAGC TGAGATGGAG 20 (2) INFORMATION FOR SEQ ID NO:280: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:280: CCTGGAAAGC TGAGATGGA 19 (2) INFORMATION FOR SEQ ID NO:281: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:281: CCTGGAAAGC TGAGATGG 18 (2) INFORMATION FOR SEQ ID NO:282: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 17 base pairs (B) TYPE: nucleic acid WO 00/09525 PCTIUS99/17712 EPI-109 304 (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:282: CCTGGAAAGC TGAGATG 17 (2) INFORMATION FOR SEQ ID NO:283: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 16 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:283: CCTGGAAAGC TGAGAT 16 (2) INFORMATION FOR SEQ ID NO:284: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:284: CCTGGAAAGC TGAGA 15 (2) INFORMATION FOR SEQ ID NO:285: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:285: CCTGGAAAGC TGAG 14 (2) INFORMATION FOR SEQ ID NO:286: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 13 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:286: CCTGGAAAGC TGA 13 (2) INFORMATION FOR SEQ ID NO:287: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 12 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:287: CCTGGAAAGC TG 12 (2) INFORMATION FOR SEQ ID NO:288: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 11 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:288: CCTGGAAAGC T 11 (2) INFORMATION FOR SEQ ID NO:289: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 10 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:289: CCTGGAAAGC 10 WO 00/09525 PCT/US99/17712 EPI-109 305 (2) INFORMATION FOR SEQ ID NO:290: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 45 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:290: CTGGAAAGCT GAGATGGAGG GCGGCATGGC GGGCACAGGC TGGGC 45 (2) INFORMATION FOR SEQ ID NO:291: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 44 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:291: CTGGAAAGCT GAGATGGAGG GCGGCATGGC GGGCACAGGC TGGG 44 (2) INFORMATION FOR SEQ ID NO:292: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 43 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:292: CTGGAAAGCT GAGATGGAGG GCGGCATGGC GGGCACAGGC TGG 43 (2) INFORMATION FOR SEQ ID NO:293: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 42 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:293: CTGGAAAGCT GAGATGGAGG GCGGCATGGC GGGCACAGGC TG 42 (2) INFORMATION FOR SEQ ID NO:294: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 41 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:294: CTGGAAAGCT GAGATGGAGG GCGGCATGGC GGGCACAGGC T 41 (2) INFORMATION FOR SEQ ID NO:295: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 40 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:295: CTGGAAAGCT GAGATGGAGG GCGGCATGGC GGGCACAGGC 40 (2) INFORMATION FOR SEQ ID NO:296: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 39 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:296: CTGGAAAGCT GAGATGGAGG GCGGCATGGC GGGCACAGG 39 (2) INFORMATION FOR SEQ ID NO:297: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 38 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single WO 00/09525 PCTIUS99/17712 EPI-109 306 (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:297: CTGGAAAGCT GAGATGGAGG GCGGCATGGC GGGCACAG 38 (2) INFORMATION FOR SEQ ID NO:298: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 37 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:298: CTGGAAAGCT GAGATGGAGG GCGGCATGGC GGGCACA 37 (2) INFORMATION FOR SEQ ID NO:299: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 36 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:299: CTGGAAAGCT GAGATGGAGG GCGGCATGGC GGGCAC 36 (2) INFORMATION FOR SEQ ID NO:300: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 35 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:300: CTGGAAAGCT GAGATGGAGG GCGGCATGGC GGGCA 35 (2) INFORMATION FOR SEQ ID NO:301: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 34 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:301: CTGGAAAGCT GAGATGGAGG GCGGCATGGC GGGC 34 (2) INFORMATION FOR SEQ ID NO:302: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 33 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:302: CTGGAAAGCT GAGATGGAGG GCGGCATGGC GGG 33 (2) INFORMATION FOR SEQ ID NO:303: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 32 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:303: CTGGAAAGCT GAGATGGAGG GCGGCATGGC GG 32 (2) INFORMATION FOR SEQ ID NO:304: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 31 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:304: CTGGAAAGCT GAGATGGAGG GCGGCATGGC G 31 (2) INFORMATION FOR SEQ ID NO:305: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 30 base pairs (B) TYPE: nucleic acid WO 00/09525 PCT/US99/17712 EPI-109 307 (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:305: CTGGAAAGCT GAGATGGAGG GCGGCATGGC 30 (2) INFORMATION FOR SEQ ID NO:306: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 29 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:306: CTGGAAAGCT GAGATGGAGG GCGGCATGG 29 (2) INFORMATION FOR SEQ ID NO:307: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 28 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:307: CTGGAAAGCT GAGATGGAGG GCGGCATG 28 (2) INFORMATION FOR SEQ ID NO:308: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 27 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:308: CTGGAAAGCT GAGATGGAGG GCGGCAT 27 (2) INFORMATION FOR SEQ ID NO:309: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 26 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:309: CTGGAAAGCT GAGATGGAGG GCGGCA 26 (2) INFORMATION FOR SEQ ID NO:310: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 25 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:310: CTGGAAAGCT GAGATGGAGG GCGGC 25 (2) INFORMATION FOR SEQ ID NO:311: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 24 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:311: CTGGAAAGCT GAGATGGAGG GCGG 24 (2) INFORMATION FOR SEQ ID NO:312: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 23 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:312: CTGGAAAGCT GAGATGGAGG GCG 23 (2) INFORMATION FOR SEQ ID NO:313: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:313: WO 00/09525 PCT/US99/17712 EPI-109 308 CTGGAAAGCT GAGATGGAGG GC 22 (2) INFORMATION FOR SEQ ID NO:314: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 21 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:314: CTGGAAAGCT GAGATGGAGG G 21 (2) INFORMATION FOR SEQ ID NO:315: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 20 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:315: CTGGAAAGCT GAGATGGAGG 20 (2) INFORMATION FOR SEQ ID NO:316: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:316: CTGGAAAGCT GAGATGGAG 19 (2) INFORMATION FOR SEQ ID NO:317: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:317: CTGGAAAGCT GAGATGGA 18 (2) INFORMATION FOR SEQ ID NO:318: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 17 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:318: CTGGAAAGCT GAGATGG 17 (2) INFORMATION FOR SEQ ID NO:319: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 16 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:319: CTGGAAAGCT GAGATG 16 (2) INFORMATION FOR SEQ ID NO:320: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear ' (xi) SEQUENCE DESCRIPTION: SEQ ID NO:320: CTGGAAAGCT GAGAT 15 (2) INFORMATION FOR SEQ ID NO:321: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:321: CTGGAAAGCT GAGA 14 (2) INFORMATION FOR SEQ ID NO:322: WO 00/09525 PCT/US99/17712 EPI-109 309 (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 13 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:322: CTGGAAAGCT GAG 13 (2) INFORMATION FOR SEQ ID NO:323: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 12 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:323: CTGGAAAGCT GA 12 (2) INFORMATION FOR SEQ ID NO:324: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 11 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:324: CTGGAAAGCT G 11 (2) INFORMATION FOR SEQ ID NO:325: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 10 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:325: CTGGAAAGCT 10 (2) INFORMATION FOR SEQ ID NO:326: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 44 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:326: TGGAAAGCTG AGATGGAGGG CGGCATGGCG GGCACAGGCT GGGC 44 (2) INFORMATION FOR SEQ ID NO:327: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 43 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:327: TGGAAAGCTG AGATGGAGGG CGGCATGGCG GGCACAGGCT GGG 43 (2) INFORMATION FOR SEQ ID NO:328: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 42 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:328: TGGAAAGCTG AGATGGAGGG CGGCATGGCG GGCACAGGCT GG 42 (2) INFORMATION FOR SEQ ID NO:329: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 41 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:329: TGGAAAGCTG AGATGGAGGG CGGCATGGCG GGCACAGGCT G 41 (2) INFORMATION FOR SEQ ID NO:330: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 40 base pairs (B) TYPE: nucleic acid WO 00/09525 PCT/US99/17712 EPI-109 310 (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:330: TGGAAAGCTG AGATGGAGGG CGGCATGGCG GGCACAGGCT 40 (2) INFORMATION FOR SEQ ID NO:331: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 39 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:331: TGGAAAGCTG AGATGGAGGG CGGCATGGCG GGCACAGGC 39 (2) INFORMATION FOR SEQ ID NO:332: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 38 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:332: TGGAAAGCTG AGATGGAGGG CGGCATGGCG GGCACAGG 38 (2) INFORMATION FOR SEQ ID NO:333: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 37 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:333: TGGAAAGCTG AGATGGAGGG CGGCATGGCG GGCACAG 37 (2) INFORMATION FOR SEQ ID NO:334: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 36 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:334: TGGAAAGCTG AGATGGAGGG CGGCATGGCG GGCACA 36 (2) INFORMATION FOR SEQ ID NO:335: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 35 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:335: TGGAAAGCTG AGATGGAGGG CGGCATGGCG GGCAC 35 (2) INFORMATION FOR SEQ ID NO:336: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 34 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:336: TGGAAAGCTG AGATGGAGGG CGGCATGGCG GGCA 34 (2) INFORMATION FOR SEQ ID NO:337: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 33 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:337: TGGAAAGCTG AGATGGAGGG CGGCATGGCG GGC 33 (2) INFORMATION FOR SEQ ID NO:338: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 32 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:338: WO 00/09525 PCT/US99/17712 EPI-109 311 TGGAAAGCTG AGATGGAGGG CGGCATGGCG GG 32 (2) INFORMATION FOR SEQ ID NO:339: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 31 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:339: TGGAAAGCTG AGATGGAGGG CGGCATGGCG G 31 (2) INFORMATION FOR SEQ ID NO:340: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 30 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:340: TGGAAAGCTG AGATGGAGGG CGGCATGGCG 30 (2) INFORMATION FOR SEQ ID NO:341: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 29 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:341: TGGAAAGCTG AGATGGAGGG CGGCATGGC 29 (2) INFORMATION FOR SEQ ID NO:342: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 28 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:342: TGGAAAGCTG AGATGGAGGG CGGCATGG 28 (2) INFORMATION FOR SEQ ID NO:343: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 27 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:343: TGGAAAGCTG AGATGGAGGG CGGCATG 27 (2) INFORMATION FOR SEQ ID NO:344: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 26 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:344: TGGAAAGCTG AGATGGAGGG CGGCAT 26 (2) INFORMATION FOR SEQ ID NO:345: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 25 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:345: TGGAAAGCTG AGATGGAGGG CGGCA 25 (2) INFORMATION FOR SEQ ID NO:346: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 24 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:346: TGGAAAGCTG AGATGGAGGG CGGC 24 (2) INFORMATION FOR SEQ ID NO:347: WO 00/09525 PCT/US99/17712 EPI-109 312 (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 23 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:347: TGGAAAGCTG AGATGGAGGG CGG 23 (2) INFORMATION FOR SEQ ID NO:348: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:348: TGGAAAGCTG AGATGGAGGG CG 22 (2) INFORMATION FOR SEQ ID NO:349: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 21 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:349: TGGAAAGCTG AGATGGAGGG C 21 (2) INFORMATION FOR SEQ ID NO:350: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 20 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:350: TGGAAAGCTG AGATGGAGGG 20 (2) INFORMATION FOR SEQ ID NO:351: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:351: TGGAAAGCTG AGATGGAGG 19 (2) INFORMATION FOR SEQ ID NO:352: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:352: TGGAAAGCTG AGATGGAG 18 (2) INFORMATION FOR SEQ ID NO:353: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 17 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:353: TGGAAAGCTG AGATGGA 17 (2) INFORMATION FOR SEQ ID NO:354: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 16 base pairs (8) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:354: TGGAAAGCTG AGATGG 16 (2) INFORMATION FOR SEQ ID NO:355: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid WO 00/09525 PCTIUS99/17712 EPI-109 313 (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:355: TGGAAAGCTG AGATG 15 (2) INFORMATION FOR SEQ ID NO:356: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:356: TGGAAAGCTG AGAT 14 (2) INFORMATION FOR SEQ ID NO:357: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 13 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:357: TGGAAAGCTG AGA 13 (2) INFORMATION FOR SEQ ID NO:358: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 12 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:358: TGGAAAGCTG AG 12 (2) INFORMATION FOR SEQ ID NO:359: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 11 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:359: TGGAAAGCTG A 11 (2) INFORMATION FOR SEQ ID NO:360: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 10 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:360: TGGAAAGCTG 10 (2) INFORMATION FOR SEQ ID NO:361: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 43 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:361: GGAAAGCTGA GATGGAGGGC GGCATGGCGG GCACAGGCTG GGC 43 (2) INFORMATION FOR SEQ ID NO:362: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 42 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:362: GGAAAGCTGA GATGGAGGGC GGCATGGCGG GCACAGGCTG GG 42 (2) INFORMATION FOR SEQ ID NO:363: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 41 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:363: WO 00/09525 PCT/US99/17712 EPI-109 314 GGAAAGCTGA GATGGAGGGC GGCATGGCGG GCACAGGCTG G 41 (2) INFORMATION FOR SEQ ID NO:364: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 40 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:364: GGAAAGCTGA GATGGAGGGC GGCATGGCGG GCACAGGCTG 40 (2) INFORMATION FOR SEQ ID NO:365: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 39 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:365: GGAAAGCTGA GATGGAGGGC GGCATGGCGG GCACAGGCT 39 (2) INFORMATION FOR SEQ ID NO:366: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 38 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:366: GGAAAGCTGA GATGGAGGGC GGCATGGCGG GCACAGGC 38 (2) INFORMATION FOR SEQ ID NO:367: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 0 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:367: (2) INFORMATION FOR SEQ ID NO:368: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 36 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:368: GGAAAGCTGA GATGGAGGGC GGCATGGCGG GCACAG 36 (2) INFORMATION FOR SEQ ID NO:369: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 35 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:369: GGAAAGCTGA GATGGAGGGC GGCATGGCGG GCACA 35 (2) INFORMATION FOR SEQ ID NO:370: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 34 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:370: GGAAAGCTGA GATGGAGGGC GGCATGGCGG GCAC 34 (2) INFORMATION FOR SEQ ID NO:371: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 33 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:371: GGAAAGCTGA GATGGAGGGC GGCATGGCGG GCA 33 (2) INFORMATION FOR SEQ ID NO:372: WO 00/09525 PCT/US99/17712 EPI-109 315 (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 32 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:372: GGAAAGCTGA GATGGAGGGC GGCATGGCGG GC 32 (2) INFORMATION FOR SEQ ID NO:373: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 31 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:373: GGAAAGCTGA GATGGAGGGC GGCATGGCGG G 31 (2) INFORMATION FOR SEQ ID NO:374: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 30 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:374: GGAAAGCTGA GATGGAGGGC GGCATGGCGG 30 (2) INFORMATION FOR SEQ ID NO:375: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 29 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:375: GGAAAGCTGA GATGGAGGGC GGCATGGCG 29 (2) INFORMATION FOR SEQ ID NO:376: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 28 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:376: GGAAAGCTGA GATGGAGGGC GGCATGGC 28 (2) INFORMATION FOR SEQ ID NO:377: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 27 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:377: GGAAAGCTGA GATGGAGGGC GGCATGG 27 (2) INFORMATION FOR SEQ ID NO:378: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 26 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:378: GGAAAGCTGA GATGGAGGGC GGCATG 26 (2) INFORMATION FOR SEQ ID NO:379: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 25 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:379: GGAAAGCTGA GATGGAGGGC GGCAT 25 (2) INFORMATION FOR SEQ ID NO:380: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 24 base pairs (B) TYPE: nucleic acid WO 00/09525 PCT/US99/17712 EPI-109 316 (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:380: GGAAAGCTGA GATGGAGGGC GGCA 24 (2) INFORMATION FOR SEQ ID NO:381: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 23 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:381: GGAAAGCTGA GATGGAGGGC GGC 23 (2) INFORMATION FOR SEQ ID NO:382: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:382: GGAAAGCTGA GATGGAGGGC GG 22 (2) INFORMATION FOR SEQ ID NO:383: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 21 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:383: GGAAAGCTGA GATGGAGGGC G 21 (2) INFORMATION FOR SEQ ID NO:384: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 20 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:384: GGAAAGCTGA GATGGAGGGC 20 (2) INFORMATION FOR SEQ ID NO:385: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:385: GGAAAGCTGA GATGGAGGG 19 (2) INFORMATION FOR SEQ ID NO:386: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:386: GGAAAGCTGA GATGGAGG 18 (2) INFORMATION FOR SEQ ID NO:387: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 17 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi-) SEQUENCE DESCRIPTION: SEQ ID NO:387: GGAAAGCTGA GATGGAGG 18 (2) INFORMATION FOR SEQ ID NO:388: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 16 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:388: WO 00/09525 PCTIUS99/17712 EPI-109 317 GGAAAGCTGA GATGGA 16 (2) INFORMATION FOR SEQ ID NO:389: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:389: GGAAAGCTGA GATGG 15 (2) INFORMATION FOR SEQ ID NO:390: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:390: GGAAAGCTGA GATG 14 (2) INFORMATION FOR SEQ ID NO:391: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 13 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:391: GGAAAGCTGA GAT 13 (2) INFORMATION FOR SEQ ID NO:392: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 12 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:392: GGAAAGCTGA GA 12 (2) INFORMATION FOR SEQ ID NO:393: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 11 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:393: GGAAAGCTGA G 11 (2) INFORMATION FOR SEQ ID NO:394: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 10 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:394: GGAAAGCTGA 10 (2) INFORMATION FOR SEQ ID NO:395: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 42 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:395: GAAAGCTGAG ATGGAGGGCG GCATGGCGGG CACAGGCTGG GC 42 (2) INFORMATION FOR SEQ ID NO:396: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 41 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:396: GAAAGCTGAG ATGGAGGGCG GCATGGCGGG CACAGGCTGG G 41 (2) INFORMATION FOR SEQ ID NO:397: WO 00/09525 PCT/US99/17712 EPI-109 318 (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 40 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:397: GAAAGCTGAG ATGGAGGGCG GCATGGCGGG CACAGGCTGG 40 (2) INFORMATION FOR SEQ ID NO:398: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 39 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:398: GAAAGCTGAG ATGGAGGGCG GCATGGCGGG CACAGGCTG 39 (2) INFORMATION FOR SEQ ID NO:399: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 38 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:399: GAAAGCTGAG ATGGAGGGCG GCATGGCGGG CACAGGCT 38 (2) INFORMATION FOR SEQ ID NO:400: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 37 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:400: GAAAGCTGAG ATGGAGGGCG GCATGGCGGG CACAGGC 37 (2) INFORMATION FOR SEQ ID NO:401: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 36 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:401: GAAAGCTGAG ATGGAGGGCG GCATGGCGGG CACAGG 36 (2) INFORMATION FOR SEQ ID NO:402: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 35 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:402: GAAAGCTGAG ATGGAGGGCG GCATGGCGGG CACAG 35 (2) INFORMATION FOR SEQ ID NO:403: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 34 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:403: GAAAGCTGAG ATGGAGGGCG GCATGGCGGG CACA 34 (2) INFORMATION FOR SEQ ID NO:404: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 33 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:404: GAAAGCTGAG ATGGAGGGCG GCATGGCGGG CACA 34 (2) INFORMATION FOR SEQ ID NO:405: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 32 base pairs (B) TYPE: nucleic acid WO 00/09525 PCT/US99/17712 EPI-109 319 (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:405: GAAAGCTGAG ATGGAGGGCG GCATGGCGGG CA 32 (2) INFORMATION FOR SEQ ID NO:406: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 31 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:406: GAAAGCTGAG ATGGAGGGCG GCATGGCGGG C 31 (2) INFORMATION FOR SEQ ID NO:407: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 30 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:407: GAAAGCTGAG ATGGAGGGCG GCATGGCGGG 30 (2) INFORMATION FOR SEQ ID NO:408: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 29 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:408: GAAAGCTGAG ATGGAGGGCG GCATGGCGG 29 (2) INFORMATION FOR SEQ ID NO:409: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 28 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:409: GAAAGCTGAG ATGGAGGGCG GCATGGCG 28 (2) INFORMATION FOR SEQ ID NO:410: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 27 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:410: GAAAGCTGAG ATGGAGGGCG GCATGGC 27 (2) INFORMATION FOR SEQ ID NO:411: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 26 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:411: GAAAGCTGAG ATGGAGGGCG GCATGG 26 (2) INFORMATION FOR SEQ ID NO:412: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 25 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:412: GAAAGCTGAG ATGGAGGGCG GCATG 25 (2) INFORMATION FOR SEQ ID NO:413: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 24 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:413: WO 00/09525 PCT/US99/17712 EPI-109 320 GAAAGCTGAG ATGGAGGGCG GCAT 24 (2) INFORMATION FOR SEQ ID NO:414: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 23 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:414: GAAAGCTGAG ATGGAGGGCG GCA 23 (2) INFORMATION FOR SEQ ID NO:415: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:415: GAAAGCTGAG ATGGAGGGCG GC 22 (2) INFORMATION FOR SEQ ID NO:416: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 21 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:416: GAAAGCTGAG ATGGAGGGCG G 21 (2) INFORMATION FOR SEQ ID NO:417: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 20 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:417: GAAAGCTGAG ATGGAGGGCG 20 (2) INFORMATION FOR SEQ ID NO:418: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:418: GAAAGCTGAG ATGGAGGGC 19 (2) INFORMATION FOR SEQ ID NO:419: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:419: GAAAGCTGAG ATGGAGGG 18 (2) INFORMATION FOR SEQ ID NO:420: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 17 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:420: GAAAGCTGAG ATGGAGG 17 (2) INFORMATION FOR SEQ ID NO:421: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 16 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:421: GAAAGCTGAG ATGGAG 16 (2) INFORMATION FOR SEQ ID NO:422: WO 00/09525 PCT/US99/17712 EPI-109 321 (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:422: GAAAGCTGAG ATGGA 15 (2) INFORMATION FOR SEQ ID NO:423: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:423: GAAAGCTGAG ATGG 14 (2) INFORMATION FOR SEQ ID NO:424: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 13 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:424: GAAAGCTGAG ATG 13 (2) INFORMATION FOR SEQ ID NO:425: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 12 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:425: GAAAGCTGAG AT 12 (2) INFORMATION FOR SEQ ID NO:426: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 11 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:426: GAAAGCTGAG A 11 (2) INFORMATION FOR SEQ ID NO:427: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 10 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:427: GAAAGCTGAG 10 (2) INFORMATION FOR SEQ ID NO:428: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 41 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:428: AAAGCTGAGA TGGAGGGCGG CATGGCGGGC ACAGGCTGGG C 41 (2) INFORMATION FOR SEQ ID NO:429: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 40 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:429: AAAGCTGAGA TGGAGGGCGG CATGGCGGGC ACAGGCTGGG 40 (2) INFORMATION FOR SEQ ID NO:430: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 39 base pairs (B) TYPE: nucleic acid WO 00/09525 PCT/US99/17712 EPI-109 322 (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:430: AAAGCTGAGA TGGAGGGCGG CATGGCGGGC ACAGGCTGG 39 (2) INFORMATION FOR SEQ ID NO:431: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 38 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:431: AAAGCTGAGA TGGAGGGCGG CATGGCGGGC ACAGGCTG 38 (2) INFORMATION FOR SEQ ID NO:432: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 37 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:432: AAAGCTGAGA TGGAGGGCGG CATGGCGGGC ACAGGCT 37 (2) INFORMATION FOR SEQ ID NO:433: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 36 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:433: AAAGCTGAGA TGGAGGGCGG CATGGCGGGC ACAGGC 36 (2) INFORMATION FOR SEQ ID NO:434: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 35 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:434: AAAGCTGAGA TGGAGGGCGG CATGGCGGGC ACAGG 35 (2) INFORMATION FOR SEQ ID NO:435: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 34 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:435: AAAGCTGAGA TGGAGGGCGG CATGGCGGGC ACAG 34 (2) INFORMATION FOR SEQ ID NO:436: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 33 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:436: AAAGCTGAGA TGGAGGGCGG CATGGCGGGC ACA 33 (2) INFORMATION FOR SEQ ID NO:437: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 32 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear ' (xi) SEQUENCE DESCRIPTION: SEQ ID NO:437: AAAGCTGAGA TGGAGGGCGG CATGGCGGGC AC 32 (2) INFORMATION FOR SEQ ID NO:438: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 31 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:438: WO 00/09525 PCT/US99/17712 EPI-109 323 AAAGCTGAGA TGGAGGGCGG CATGGCGGGC A 31 (2) INFORMATION FOR SEQ ID NO:439: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 30 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:439: AAAGCTGAGA TGGAGGGCGG CATGGCGGGC 30 (2) INFORMATION FOR SEQ ID NO:440: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 29 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:440: AAAGCTGAGA TGGAGGGCGG CATGGCGGG 29 (2) INFORMATION FOR SEQ ID NO:441: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 28 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:441: AAAGCTGAGA TGGAGGGCGG CATGGCGG 28 (2) INFORMATION FOR SEQ ID NO:442: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 27 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:442: AAAGCTGAGA TGGAGGGCGG CATGGCG 27 (2) INFORMATION FOR SEQ ID NO:443: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 26 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:443: AAAGCTGAGA TGGAGGGCGG CATGGC 26 (2) INFORMATION FOR SEQ ID NO:444: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 25 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:444: AAAGCTGAGA TGGAGGGCGG CATGG 25 (2) INFORMATION FOR SEQ ID NO:445: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 24 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:445: AAAGCTGAGA TGGAGGGCGG CATG 24 .(2) INFORMATION FOR SEQ ID NO:446: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 23 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:446: AAAGCTGAGA TGGAGGGCGG CAT 23 (2) INFORMATION FOR SEQ ID NO:447: WO 00/09525 PCT/US99/17712 EPI-109 324 (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:447: AAAGCTGAGA TGGAGGGCGG CA 22 (2) INFORMATION FOR SEQ ID NO:448: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 21 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:448: AAAGCTGAGA TGGAGGGCGG C 21 (2) INFORMATION FOR SEQ ID NO:449: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 20 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:449: AAAGCTGAGA TGGAGGGCGG 20 (2) INFORMATION FOR SEQ ID NO:450: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:450: AAAGCTGAGA TGGAGGGCG 19 (2) INFORMATION FOR SEQ ID NO:451: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:451: AAAGCTGAGA TGGAGGGC 18 (2) INFORMATION FOR SEQ ID NO:452: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 17 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:452: AAAGCTGAGA TGGAGGG 17 (2) INFORMATION FOR SEQ ID NO:453: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 16 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:453: AAAGCTGAGA TGGAGG 16 (2) INFORMATION FOR SEQ ID NO:454: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:454: AAAGCTGAGA TGGAG 15 (2) INFORMATION FOR SEQ ID NO:455: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid WO 00/09525 PCT/US99/17712 EPI-109 325 (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:455: AAAGCTGAGA TGGA 14 (2) INFORMATION FOR SEQ ID NO:456: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 13 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:456: AAAGCTGAGA TGG 13 (2) INFORMATION FOR SEQ ID NO:457: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 12 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:457: AAAGCTGAGA TG 12 (2) INFORMATION FOR SEQ ID NO:458: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 11 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:458: AAAGCTGAGA T 11 (2) INFORMATION FOR SEQ ID NO:459: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 10 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:459: AAAGCTGAGA 10 (2) INFORMATION FOR SEQ ID NO:460: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 40 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:460: AAGCTGAGAT GGAGGGCGGC ATGGCGGGCA CAGGCTGGGC 40 (2) INFORMATION FOR SEQ ID NO:461: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 39 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:461: AAAGCTGAGA T 11 (2) INFORMATION FOR SEQ ID NO:462: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 38 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:462: AAGCTGAGAT GGAGGGCGGC ATGGCGGGCA CAGGCTGG 38 (2) INFORMATION FOR SEQ ID NO:463: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 37 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:463: WO 00/09525 PCT/US99/17712 EPI-109 326 AAGCTGAGAT GGAGGGCGGC ATGGCGGGCA CAGGCTG 37 (2) INFORMATION FOR SEQ ID NO:464: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 36 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:464: AAGCTGAGAT GGAGGGCGGC ATGGCGGGCA CAGGCT 36 (2) INFORMATION FOR SEQ ID NO:465: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 35 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:465: AAGCTGAGAT GGAGGGCGGC ATGGCGGGCA CAGGC 35 (2) INFORMATION FOR SEQ ID NO:466: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 34 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:466: AAGCTGAGAT GGAGGGCGGC ATGGCGGGCA CAGG 34 (2) INFORMATION FOR SEQ ID NO:467: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 33 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:467: AAGCTGAGAT GGAGGGCGGC ATGGCGGGCA CAG 33 (2) INFORMATION FOR SEQ ID NO:468: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 32 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:468: AAGCTGAGAT GGAGGGCGGC ATGGCGGGCA CA 32 (2) INFORMATION FOR SEQ ID NO:469: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 31 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:469: AAGCTGAGAT GGAGGGCGGC ATGGCGGGCA C 31 (2) INFORMATION FOR SEQ ID NO:470: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 30 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:470: AAGCTGAGAT GGAGGGCGGC ATGGCGGGCA 30 (2) INFORMATION FOR SEQ ID NO:471: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 29 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:471: AAGCTGAGAT GGAGGGCGGC ATGGCGGGC 29 (2) INFORMATION FOR SEQ ID NO:472: WO 00/09525 PCT/US99/17712 EPI-109 327 (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 28 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:472: AAGCTGAGAT GGAGGGCGGC ATGGCGGG 28 (2) INFORMATION FOR SEQ ID NO:473: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 27 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:473: AAGCTGAGAT GGAGGGCGGC ATGGCGG 27 (2) INFORMATION FOR SEQ ID NO:474: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 26 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear ~ (xi) SEQUENCE DESCRIPTION: SEQ ID NO:474: AAGCTGAGAT GGAGGGCGGC ATGGCG 26 (2) INFORMATION FOR SEQ ID NO:475: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 25 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:475: AAGCTGAGAT GGAGGGCGGC ATGGC 25 (2) INFORMATION FOR SEQ ID NO:476: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 24 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:476: AAGCTGAGAT GGAGGGCGGC ATGG 24 (2) INFORMATION FOR SEQ ID NO:477: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 23 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:477: AAGCTGAGAT GGAGGGCGGC ATG 23 (2) INFORMATION FOR SEQ ID NO:478: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:478: AAGCTGAGAT GGAGGGCGGC AT 22 (2) INFORMATION FOR SEQ ID NO:479: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 21 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:479: AAGCTGAGAT GGAGGGCGGC A 21 (2) INFORMATION FOR SEQ ID NO:480: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 20 base pairs (B) TYPE: nucleic acid WO 00/09525 PCTIUS99/17712 EPI-109 328 (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:480: AAGCTGAGAT GGAGGGCGGC 20 (2) INFORMATION FOR SEQ ID NO:481: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:481: AAGCTGAGAT GGAGGGCGG 19 (2) INFORMATION FOR SEQ ID NO:482: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:482: AAGCTGAGAT GGAGGGCG 18 (2) INFORMATION FOR SEQ ID NO:483: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 17 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:483: AAGCTGAGAT GGAGGGC 17 (2) INFORMATION FOR SEQ ID NO:484: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 16 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:484: AAGCTGAGAT GGAGGG 16 (2) INFORMATION FOR SEQ ID NO:485: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:485: AAGCTGAGAT GGAGG 15 (2) INFORMATION FOR SEQ ID NO:486: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:486: AAGCTGAGAT GGAG 14 (2) INFORMATION FOR SEQ ID NO:487: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 13 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:487: AAGCTGAGAT GGA 13 (2) INFORMATION FOR SEQ ID NO:488: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 12 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:488: WO 00/09525 PCT/US99/17712 EPI-109 329 AAGCTGAGAT GG 12 (2) INFORMATION FOR SEQ ID NO:489: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 11 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:489: AAGCTGAGAT G 11 (2) INFORMATION FOR SEQ ID NO:490: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 10 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:490: AAGCTGAGAT 10 (2) INFORMATION FOR SEQ ID NO:491: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 39 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:491: AGCTGAGATG GAGGGCGGCA TGGCGGGCAC AGGCTGGGC 39 (2) INFORMATION FOR SEQ ID NO:492: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 38 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:492: AGCTGAGATG GAGGGCGGCA TGGCGGGCAC AGGCTGGG 38 (2) INFORMATION FOR SEQ ID NO:493: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 37 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:493: AGCTGAGATG GAGGGCGGCA TGGCGGGCAC AGGCTGG 37 (2) INFORMATION FOR SEQ ID NO:494: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 36 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:494: AGCTGAGATG GAGGGCGGCA TGGCGGGCAC AGGCTG 36 (2) INFORMATION FOR SEQ ID NO:495: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 35 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:495: AGCTGAGATG GAGGGCGGCA TGGCGGGCAC AGGCT 35 (2) INFORMATION FOR SEQ ID NO:496: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 34 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:496: AGCTGAGATG GAGGGCGGCA TGGCGGGCAC AGGC 34 (2) INFORMATION FOR SEQ ID NO:497: WO 00/09525 PCTUS99/17712 EPI-109 330 (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 33 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:497: AGCTGAGATG GAGGGCGGCA TGGCGGGCAC AGG 33 (2) INFORMATION FOR SEQ ID NO:498: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 32 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:498: AGCTGAGATG GAGGGCGGCA TGGCGGGCAC AG 32 (2) INFORMATION FOR SEQ ID NO:499: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 31 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:499: AGCTGAGATG GAGGGCGGCA TGGCGGGCAC A 31 (2) INFORMATION FOR SEQ ID NO:500: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 30 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:500: AGCTGAGATG GAGGGCGGCA TGGCGGGCAC 30 (2) INFORMATION FOR SEQ ID NO:501: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 29 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:501: AGCTGAGATG GAGGGCGGCA TGGCGGGCA 29 (2) INFORMATION FOR SEQ ID NO:502: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 28 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:502: AGCTGAGATG GAGGGCGGCA TGGCGGGC 28 (2) INFORMATION FOR SEQ ID NO:503: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 27 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:503: AGCTGAGATG GAGGGCGGCA TGGCGGG 27 (2) INFORMATION FOR SEQ ID NO:504: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 26 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:504: AGCTGAGATG GAGGGCGGCA TGGCGG 26 (2) INFORMATION FOR SEQ ID NO:505: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 25 base pairs (B) TYPE: nucleic acid WO 00/09525 PCT/US99/17712 EPI-109 331 (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:505: AGCTGAGATG GAGGGCGGCA TGGCG 25 (2) INFORMATION FOR SEQ ID NO:506: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 24 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:506: AGCTGAGATG GAGGGCGGCA TGGC 24 (2) INFORMATION FOR SEQ ID NO:507: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 23 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:507: AGCTGAGATG GAGGGCGGCA TGG 23 (2) INFORMATION FOR SEQ ID NO:508: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:508: AGCTGAGATG GAGGGCGGCA TG 22 (2) INFORMATION FOR SEQ ID NO:509: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 21 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:509: AGCTGAGATG GAGGGCGGCA T 21 (2) INFORMATION FOR SEQ ID NO:510: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 20 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:510: AGCTGAGATG GAGGGCGGCA 20 (2) INFORMATION FOR SEQ ID NO:511: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:511: AGCTGAGATG GAGGGCGGC 19 (2) INFORMATION FOR SEQ ID NO:512: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:512: AGCTGAGATG GAGGGCGG 18 (2) INFORMATION FOR SEQ ID NO:513: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 17 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:513: WO 00/09525 PCTIUS99/17712 EPI-109 332 AGCTGAGATG GAGGGCG 17 (2) INFORMATION FOR SEQ ID NO:514: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 16 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear ' (xi) SEQUENCE DESCRIPTION: SEQ ID NO:514: AGCTGAGATG GAGGGC 16 (2) INFORMATION FOR SEQ ID NO:515: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:515: AGCTGAGATG GAGGG 15 (2) INFORMATION FOR SEQ ID NO:516: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:516: AGCTGAGATG GAGG 14 (2) INFORMATION FOR SEQ ID NO:517: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 13 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:517: AGCTGAGATG GAG 13 (2) INFORMATION FOR SEQ ID NO:518: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 12 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:518: AGCTGAGATG GA 12 (2) INFORMATION FOR SEQ ID NO:519: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 11 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:519: AGCTGAGATG G 11 (2) INFORMATION FOR SEQ ID NO:520: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 10 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:520: AGCTGAGATG 10 *(2) INFORMATION FOR SEQ ID NO:521: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 38 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:521: GCTGAGATGG AGGGCGGCAT GGCGGGCACA GGCTGGGC 38 (2) INFORMATION FOR SEQ ID NO:522: WO 00/09525 PCT/US99/17712 EPI-109 333 (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 37 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:522: GCTGAGATGG AGGGCGGCAT GGCGGGCACA GGCTGGG 37 (2) INFORMATION FOR SEQ ID NO:523: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 36 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:523: GCTGAGATGG AGGGCGGCAT GGCGGGCACA GGCTGG 36 (2) INFORMATION FOR SEQ ID NO:524: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 35 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:524: GCTGAGATGG AGGGCGGCAT GGCGGGCACA GGCTG 35 (2) INFORMATION FOR SEQ ID NO:525: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 34 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:525: GCTGAGATGG AGGGCGGCAT GGCGGGCACA GGCT 34 (2) INFORMATION FOR SEQ ID NO:526: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 33 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:526: GCTGAGATGG AGGGCGGCAT GGCGGGCACA GGC 33 (2) INFORMATION FOR SEQ ID NO:527: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 32 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:527: GCTGAGATGG AGGGCGGCAT GGCGGGCACA GG 32 (2) INFORMATION FOR SEQ ID NO:528: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 31 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:528: GCTGAGATGG AGGGCGGCAT GGCGGGCACA G 31 (2) INFORMATION FOR SEQ ID NO:529: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 30 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:529: GCTGAGATGG AGGGCGGCAT GGCGGGCACA 30 (2) INFORMATION FOR SEQ ID NO:530: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 29 base pairs (B) TYPE: nucleic acid WO 00/09525 PCT/US99/17712 EPI-109 334 (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:530: GCTGAGATGG AGGGCGGCAT GGCGGGCAC 29 (2) INFORMATION FOR SEQ ID NO:531: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 28 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:531: GCTGAGATGG AGGGCGGCAT GGCGGGCA 28 (2) INFORMATION FOR SEQ ID NO:532: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 27 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:532: GCTGAGATGG AGGGCGGCAT GGCGGGC 27 (2) INFORMATION FOR SEQ ID NO:533: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 26 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:533: GCTGAGATGG AGGGCGGCAT GGCGGG 26 (2) INFORMATION FOR SEQ ID NO:534: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 25 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:534: GCTGAGATGG AGGGCGGCAT GGCGG 25 (2) INFORMATION FOR SEQ ID NO:535: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 24 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:535: GCTGAGATGG AGGGCGGCAT GGCG 24 (2) INFORMATION FOR SEQ ID NO:536: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 23 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:536: GCTGAGATGG AGGGCGGCAT GGC 23 (2) INFORMATION FOR SEQ ID NO:537: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:537: GCTGAGATGG AGGGCGGCAT GG 22 (2) INFORMATION FOR SEQ ID NO:538: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 21 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:538: WO 00/09525 PCT/US99/17712 EPI-109 335 GCTGAGATGG AGGGCGGCAT G 21 (2) INFORMATION FOR SEQ ID NO:539: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 20 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:539: GCTGAGATGG AGGGCGGCAT 20 (2) INFORMATION FOR SEQ ID NO:540: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:540: GCTGAGATGG AGGGCGGCA 19 (2) INFORMATION FOR SEQ ID NO:541: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:541: GCTGAGATGG AGGGCGGC 18 (2) INFORMATION FOR SEQ ID NO:542: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 17 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:542: GCTGAGATGG AGGGCGG 17 (2) INFORMATION FOR SEQ ID NO:543: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 16 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:543: GCTGAGATGG AGGGCG 16 (2) INFORMATION FOR SEQ ID NO:544: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:544: GCTGAGATGG AGGGC 15 (2) INFORMATION FOR SEQ ID NO:545: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:545: GCTGAGATGG AGGG 14 -(2) INFORMATION FOR SEQ ID NO:546: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 13 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:546: GCTGAGATGG AGG 13 (2) INFORMATION FOR SEQ ID NO:547: WO 00/09525 PCTUS99/17712 EPI-109 336 (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 12 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:547: GCTGAGATGG AG 12 (2) INFORMATION FOR SEQ ID NO:548: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 11 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:548: GCTGAGATGG A 11 (2) INFORMATION FOR SEQ ID NO:549: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 10 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:549: GCTGAGATGG 10 (2) INFORMATION FOR SEQ ID NO:550: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 37 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:550: CTGAGATGGA GGGCGGCATG GCGGGCACAG GCTGGGC 37 (2) INFORMATION FOR SEQ ID NO:551: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 36 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:551: CTGAGATGGA GGGCGGCATG GCGGGCACAG GCTGGG 36 (2) INFORMATION FOR SEQ ID NO:552: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 35 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:552: CTGAGATGGA GGGCGGCATG GCGGGCACAG GCTGG 35 (2) INFORMATION FOR SEQ ID NO:553: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 34 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:553: CTGAGATGGA GGGCGGCATG GCGGGCACAG GCTG 34 (2) INFORMATION FOR SEQ ID NO:554: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 33 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:554: CTGAGATGGA GGGCGGCATG GCGGGCACAG GCT 33 (2) INFORMATION FOR SEQ ID NO:555: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 32 base pairs (B) TYPE: nucleic acid WO 00/09525 PCT/US99/17712 EPI-109 337 (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:555: CTGAGATGGA GGGCGGCATG GCGGGCACAG GC 32 (2) INFORMATION FOR SEQ ID NO:556: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 31 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:556: CTGAGATGGA GGGCGGCATG GCGGGCACAG G 31 (2) INFORMATION FOR SEQ ID NO:557: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 30 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:557: CTGAGATGGA GGGCGGCATG GCGGGCACAG 30 (2) INFORMATION FOR SEQ ID NO:558: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 29 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:558: CTGAGATGGA GGGCGGCATG GCGGGCACA 29 (2) INFORMATION FOR SEQ ID NO:559: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 28 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:559: CTGAGATGGA GGGCGGCATG GCGGGCAC 28 (2) INFORMATION FOR SEQ ID NO:560: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 27 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:560: CTGAGATGGA GGGCGGCATG GCGGGCA 27 (2) INFORMATION FOR SEQ ID NO:561: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 26 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:561: CTGAGATGGA GGGCGGCATG GCGGGC 26 (2) INFORMATION FOR SEQ ID NO:562: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 25 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:562: CTGAGATGGA GGGCGGCATG GCGGG 25 (2) INFORMATION FOR SEQ ID NO:563: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 24 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:563: WO 00/09525 PCT/US99/17712 EPI-109 338 CTGAGATGGA GGGCGGCATG GCGG 24 (2) INFORMATION FOR SEQ ID NO:564: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 23 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:564: CTGAGATGGA GGGCGGCATG GCG 23 (2) INFORMATION FOR SEQ ID NO:565: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:565: CTGAGATGGA GGGCGGCATG GC 22 (2) INFORMATION FOR SEQ ID NO:566: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 21 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:566: CTGAGATGGA GGGCGGCATG G 21 (2) INFORMATION FOR SEQ ID NO:567: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 20 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:567: CTGAGATGGA GGGCGGCATG 20 (2) INFORMATION FOR SEQ ID NO:568: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:568: CTGAGATGGA GGGCGGCAT 19 (2) INFORMATION FOR SEQ ID NO:569: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:569: CTGAGATGGA GGGCGGCA 18 (2) INFORMATION FOR SEQ ID NO:570: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 17 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:570: CTGAGATGGA GGGCGGC 17 (2) INFORMATION FOR SEQ ID NO:571: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 16 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:571: CTGAGATGGA GGGCGG 16 (2) INFORMATION FOR SEQ ID NO:572: WO 00/09525 PCT/US99/17712 EPI-109 339 (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:572: CTGAGATGGA GGGCG 15 (2) INFORMATION FOR SEQ ID NO:573: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:573: CTGAGATGGA GGGC 14 (2) INFORMATION FOR SEQ ID NO:574: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 13 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:574: CTGAGATGGA GGG 13 (2) INFORMATION FOR SEQ ID NO:575: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 12 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:575: CTGAGATGGA GG 12 (2) INFORMATION FOR SEQ ID NO:576: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 11 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:576: CTGAGATGGA G 11 (2) INFORMATION FOR SEQ ID NO:577: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 10 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:577: CTGAGATGGA 10 (2) INFORMATION FOR SEQ ID NO:578: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 36 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:578: TGAGATGGAG GGCGGCATGG CGGGCACAGG CTGGGC 36 (2) INFORMATION FOR SEQ ID NO:579: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 35 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:579: TGAGATGGAG GGCGGCATGG CGGGCACAGG CTGGG 35 (2) INFORMATION FOR SEQ ID NO:580: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 34 base pairs (B) TYPE: nucleic acid WO 00/09525 PCT/US99/17712 EPI-109 340 (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:580: TGAGATGGAG GGCGGCATGG CGGGCACAGG CTGG 34 (2) INFORMATION FOR SEQ ID NO:581: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 33 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:581: TGAGATGGAG GGCGGCATGG CGGGCACAGG CTG 33 (2) INFORMATION FOR SEQ ID NO:582: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 32 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:582: TGAGATGGAG GGCGGCATGG CGGGCACAGG CT 32 (2) INFORMATION FOR SEQ ID NO:583: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 31 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:583: TGAGATGGAG GGCGGCATGG CGGGCACAGG C 31 (2) INFORMATION FOR SEQ ID NO:584: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 30 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:584: TGAGATGGAG GGCGGCATGG CGGGCACAGG 30 (2) INFORMATION FOR SEQ ID NO:585: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 29 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:585: TGAGATGGAG GGCGGCATGG CGGGCACAG 29 (2) INFORMATION FOR SEQ ID NO:586: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 28 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:586: TGAGATGGAG GGCGGCATGG CGGGCACA 28 (2) INFORMATION FOR SEQ ID NO:587: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 27 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:587: TGAGATGGAG GGCGGCATGG CGGGCAC 27 (2) INFORMATION FOR SEQ ID NO:588: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 26 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:588: WO 00/09525 PCT/US99/17712 EPI-109 341 TGAGATGGAG GGCGGCATGG CGGGCA 26 (2) INFORMATION FOR SEQ ID NO:589: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 25 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:589: TGAGATGGAG GGCGGCATGG CGGGC 25 (2) INFORMATION FOR SEQ ID NO:590: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 24 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:590: TGAGATGGAG GGCGGCATGG CGGG 24 (2) INFORMATION FOR SEQ ID NO:591: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 23 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:591: TGAGATGGAG GGCGGCATGG CGG 23 (2) INFORMATION FOR SEQ ID NO:592: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:592: TGAGATGGAG GGCGGCATGG CG 22 (2) INFORMATION FOR SEQ ID NO:593: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 21 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:593: TGAGATGGAG GGCGGCATGG C 21 (2) INFORMATION FOR SEQ ID NO:594: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 20 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:594: TGAGATGGAG GGCGGCATGG 20 (2) INFORMATION FOR SEQ ID NO:595: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:595: TGAGATGGAG GGCGGCATG 19 (2) INFORMATION FOR SEQ ID NO:596: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:596: TGAGATGGAG GGCGGCAT 18 (2) INFORMATION FOR SEQ ID NO:597: WO 00/09525 PCT/JS99/17712 EPI-109 342 (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 17 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:597: TGAGATGGAG GGCGGCA 17 (2) INFORMATION FOR SEQ ID NO:598: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 16 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:598: TGAGATGGAG GGCGGC 16 (2) INFORMATION FOR SEQ ID NO:599: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:599: TGAGATGGAG GGCGG 15 (2) INFORMATION FOR SEQ ID NO:600: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:600: TGAGATGGAG GGCG 14 (2) INFORMATION FOR SEQ ID NO:601: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 13 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:601: TGAGATGGAG GGC 13 (2) INFORMATION FOR SEQ ID NO:602: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 12 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:602: TGAGATGGAG GG 12 (2) INFORMATION FOR SEQ ID NO:603: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 11 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:603: TGAGATGGAG G 11 (2) INFORMATION FOR SEQ ID NO:604: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 10 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:604: TGAGATGGAG 10 (2) INFORMATION FOR SEQ ID NO:605: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 35 base pairs (B) TYPE: nucleic acid WO 00/09525 PCT/US99/17712 EPI-109 343 (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:605: GAGATGGAGG GCGGCATGGC GGGCACAGGC TGGGC 35 (2) INFORMATION FOR SEQ ID NO:606: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 34 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:606: GAGATGGAGG GCGGCATGGC GGGCACAGGC TGGG 34 (2) INFORMATION FOR SEQ ID NO:607: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 33 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:607: GAGATGGAGG GCGGCATGGC GGGCACAGGC TGG 33 (2) INFORMATION FOR SEQ ID NO:608: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 32 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:608: GAGATGGAGG GCGGCATGGC GGGCACAGGC TG 32 (2) INFORMATION FOR SEQ ID NO:609: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 31 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:609: GAGATGGAGG GCGGCATGGC GGGCACAGGC T 31 (2) INFORMATION FOR SEQ ID NO:610: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 29 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:610: GAGATGGAGG GCGGCATGGC GGGCACAGG 29 (2) INFORMATION FOR SEQ ID NO:611: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 29 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:611: GAGATGGAGG GCGGCATGGC GGGCACAGG 29 (2) INFORMATION FOR SEQ ID NO:612: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 28 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:612: GAGATGGAGG GCGGCATGGC GGGCACAG 28 (2) INFORMATION FOR SEQ ID NO:613: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 27 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:613: WO 00/09525 PCT/US99/17712 EPI-109 344 GAGATGGAGG GCGGCATGGC GGGCACA 27 (2) INFORMATION FOR SEQ ID NO:614: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 26 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:614: GAGATGGAGG GCGGCATGGC GGGCAC 26 (2) INFORMATION FOR SEQ ID NO:615: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 25 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:615: GAGATGGAGG GCGGCATGGC GGGCA 25 (2) INFORMATION FOR SEQ ID NO:616: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 24 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:616: GAGATGGAGG GCGGCATGGC GGGC 24 (2) INFORMATION FOR SEQ ID NO:617: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 23 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:617: GAGATGGAGG GCGGCATGGC GGG 23 (2) INFORMATION FOR SEQ ID NO:618: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:618: GAGATGGAGG GCGGCATGGC GG 22 (2) INFORMATION FOR SEQ ID NO:619: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 21 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:619: GAGATGGAGG GCGGCATGGC G 21 (2) INFORMATION FOR SEQ ID NO:620: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 20 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:620: GAGATGGAGG GCGGCATGGC 20 (2) INFORMATION FOR SEQ ID NO:621: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:621: GAGATGGAGG GCGGCATGG 19 (2) INFORMATION FOR SEQ ID NO:622: WO 00/09525 PCT/US99/17712 EPI-109 345 (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:622: GAGATGGAGG GCGGCATG 18 (2) INFORMATION FOR SEQ ID NO:623: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 17 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:623: GAGATGGAGG GCGGCAT 17 (2) INFORMATION FOR SEQ ID NO:624: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 16 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:624: GAGATGGAGG GCGGCA 16 (2) INFORMATION FOR SEQ ID NO:625: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:625: GAGATGGAGG GCGGC 15 (2) INFORMATION FOR SEQ ID NO:626: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:626: GAGATGGAGG GCGG 14 (2) INFORMATION FOR SEQ ID NO:627: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 13 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:627: GAGATGGAGG GCG 13 (2) INFORMATION FOR SEQ ID NO:628: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 12 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:628: GAGATGGAGG GC 12 (2) INFORMATION FOR SEQ ID NO:629: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 11 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:629: GAGATGGAGG G 11 (2) INFORMATION FOR SEQ ID NO:630: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 10 base pairs (B) TYPE: nucleic acid WO 00/09525 PCT/US99/17712 EPI-109 346 (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:630: GAGATGGAGG 10 (2) INFORMATION FOR SEQ ID NO:631: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 34 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:631: AGATGGAGGG CGGCATGGCG GGCACAGGCT GGGC 34 (2) INFORMATION FOR SEQ ID NO:632: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 33 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:632: AGATGGAGGG CGGCATGGCG GGCACAGGCT GGG 33 (2) INFORMATION FOR SEQ ID NO:633: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 32 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:633: AGATGGAGGG CGGCATGGCG GGCACAGGCT GG 32 (2) INFORMATION FOR SEQ ID NO:634: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 31 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:634: AGATGGAGGG CGGCATGGCG GGCACAGGCT G 31 (2) INFORMATION FOR SEQ ID NO:635: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 30 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:635: AGATGGAGGG CGGCATGGCG GGCACAGGCT 30 (2) INFORMATION FOR SEQ ID NO:636: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 29 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:636: AGATGGAGGG CGGCATGGCG GGCACAGGC 29 (2) INFORMATION FOR SEQ ID NO:637: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 28 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:637: AGATGGAGGG CGGCATGGCG GGCACAGG 28 (2) INFORMATION FOR SEQ ID NO:638: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 27 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:638: WO 00/09525 PCT/US99/17712 EPI-109 347 AGATGGAGGG CGGCATGGCG GGCACAG 27 (2) INFORMATION FOR SEQ ID NO:639: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 26 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:639: AGATGGAGGG CGGCATGGCG GGCACA 26 (2) INFORMATION FOR SEQ ID NO:640: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 25 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:640: AGATGGAGGG CGGCATGGCG GGCAC 25 (2) INFORMATION FOR SEQ ID NO:641: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 24 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:641: AGATGGAGGG CGGCATGGCG GGCA 24 (2) INFORMATION FOR SEQ ID NO:642: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 23 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:642: AGATGGAGGG CGGCATGGCG GGC 23 (2) INFORMATION FOR SEQ ID NO:643: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:643: AGATGGAGGG CGGCATGGCG GG 22 (2) INFORMATION FOR SEQ ID NO:644: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 21 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:644: AGATGGAGGG CGGCATGGCG G 21 (2) INFORMATION FOR SEQ ID NO:645: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 20 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:645: AGATGGAGGG CGGCATGGCG 20 *(2) INFORMATION FOR SEQ ID NO:646: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:646: AGATGGAGGG CGGCATGGC 19 (2) INFORMATION FOR SEQ ID NO:647: WO 00/09525 PCT/US99/17712 EPI-109 348 (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:647: AGATGGAGGG CGGCATGG 18 (2) INFORMATION FOR SEQ ID NO:648: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 17 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:648: AGATGGAGGG CGGCATG 17 (2) INFORMATION FOR SEQ ID NO:649: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 16 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:649: AGATGGAGGG CGGCAT 16 (2) INFORMATION FOR SEQ ID NO:650: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:650: AGATGGAGGG CGGCA 15 (2) INFORMATION FOR SEQ ID NO:651: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:651: AGATGGAGGG CGGC 14 (2) INFORMATION FOR SEQ ID NO:652: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 13 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:652: AGATGGAGGG CGG 13 (2) INFORMATION FOR SEQ ID NO:653: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 12 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:653: AGATGGAGGG CG 12 (2) INFORMATION FOR SEQ ID NO:654: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 11 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:654: AGATGGAGGG C 11 (2) INFORMATION FOR SEQ ID NO:655: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 10 base pairs (B) TYPE: nucleic acid WO 00/09525 PCT/US99/17712 EPI-109 349 (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:655: AGATGGAGGG 10 (2) INFORMATION FOR SEQ ID NO:656: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 33 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:656: GATGGAGGGC GGCATGGCGG GCACAGGCTG GGC 33 (2) INFORMATION FOR SEQ ID NO:657: (i) SEQUENCE CHARACTERISTICS: CA) LENGTH: 32 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:657: GATGGAGGGC GGCATGGCGG GCACAGGCTG GG 32 (2) INFORMATION FOR SEQ ID NO:658: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 31 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:658: GATGGAGGGC GGCATGGCGG GCACAGGCTG G 31 (2) INFORMATION FOR SEQ ID NO:659: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 30 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:659: GATGGAGGGC GGCATGGCGG GCACAGGCTG 30 (2) INFORMATION FOR SEQ ID NO:660: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 29 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:660: GATGGAGGGC GGCATGGCGG GCACAGGCT 29 (2) INFORMATION FOR SEQ ID NO:661: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 28 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:661: GATGGAGGGC GGCATGGCGG GCACAGGC 28 (2) INFORMATION FOR SEQ ID NO:662: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 27 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:662: GATGGAGGGC GGCATGGCGG GCACAGG 27 (2) INFORMATION FOR SEQ ID NO:663: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 26 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:663: WO 00/09525 PCT/US99/17712 EPI-109 350 GATGGAGGGC GGCATGGCGG GCACAG 26 (2) INFORMATION FOR SEQ ID NO:664: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 25 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:664: GATGGAGGGC GGCATGGCGG GCACA 25 (2) INFORMATION FOR SEQ ID NO:665: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 24 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:665: GATGGAGGGC GGCATGGCGG GCAC 24 (2) INFORMATION FOR SEQ ID NO:666: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 23 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:666: GATGGAGGGC GGCATGGCGG GCA 23 (2) INFORMATION FOR SEQ ID NO:667: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:667: GATGGAGGGC GGCATGGCGG GC 22 (2) INFORMATION FOR SEQ ID NO:668: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 21 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:668: GATGGAGGGC GGCATGGCGG G 21 (2) INFORMATION FOR SEQ ID NO:669: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 20 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:669: GATGGAGGGC GGCATGGCGG 20 (2) INFORMATION FOR SEQ ID NO:670: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:670: GATGGAGGGC GGCATGGCG 19 (2) INFORMATION FOR SEQ ID NO:671: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:671: GATGGAGGGC GGCATGGC 18 (2) INFORMATION FOR SEQ ID NO:672: WO 00/09525 PCT/US99/17712 EPI-109 351 (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 17 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:672: GATGGAGGGC GGCATGG 17 (2) INFORMATION FOR SEQ ID NO:673: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 16 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:673: GATGGAGGGC GGCATG 16 (2) INFORMATION FOR SEQ ID NO:674: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:674: GATGGAGGGC GGCAT 15 (2) INFORMATION FOR SEQ ID NO:675: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:675: GATGGAGGGC GGCA 14 (2) INFORMATION FOR SEQ ID NO:676: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 13 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:676: GATGGAGGGC GGC 13 (2) INFORMATION FOR SEQ ID NO:677: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 12 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:677: GATGGAGGGC GG 12 (2) INFORMATION FOR SEQ ID NO:678: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 11 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:678: GATGGAGGGC G 11 (2) INFORMATION FOR SEQ ID NO:679: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 10 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:679: GATGGAGGGC 10 (2) INFORMATION FOR SEQ ID NO:680: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 32 base pairs (B) TYPE: nucleic acid WO 00/09525 PCT/US99/17712 EPI-109 352 (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:680: ATGGAGGGCG GCATGGCGGG CACAGGCTGG GC 32 (2) INFORMATION FOR SEQ ID NO:681: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 31 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:681: ATGGAGGGCG GCATGGCGGG CACAGGCTGG G 31 (2) INFORMATION FOR SEQ ID NO:682: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 30 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:682: ATGGAGGGCG GCATGGCGGG CACAGGCTGG 30 (2) INFORMATION FOR SEQ ID NO:683: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 29 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:683: ATGGAGGGCG GCATGGCGGG CACAGGCTG 29 (2) INFORMATION FOR SEQ ID NO:684: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 28 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:684: ATGGAGGGCG GCATGGCGGG CACAGGCT 28 (2) INFORMATION FOR SEQ ID NO:685: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 27 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:685: ATGGAGGGCG GCATGGCGGG CACAGGC 27 (2) INFORMATION FOR SEQ ID NO:686: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 26 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:686: ATGGAGGGCG GCATGGCGGG CACAGG 26 (2) INFORMATION FOR SEQ ID NO:687: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 25 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:687: ATGGAGGGCG GCATGGCGGG CACAG 25 (2) INFORMATION FOR SEQ ID NO:688: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 24 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:688: WO 00/09525 PCT/US99/17712 EPI-109 353 ATGGAGGGCG GCATGGCGGG CACA 24 (2) INFORMATION FOR SEQ ID NO:689: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 23 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:689: ATGGAGGGCG GCATGGCGGG CAC 23 (2) INFORMATION FOR SEQ ID NO:690: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:690: ATGGAGGGCG GCATGGCGGG CA 22 (2) INFORMATION FOR SEQ ID NO:691: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 21 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:691: ATGGAGGGCG GCATGGCGGG C 21 (2) INFORMATION FOR SEQ ID NO:692: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 20 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:692: ATGGAGGGCG GCATGGCGGG 20 (2) INFORMATION FOR SEQ ID NO:693: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:693: ATGGAGGGCG GCATGGCGG 19 (2) INFORMATION FOR SEQ ID NO:694: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:694: ATGGAGGGCG GCATGGCG 18 (2) INFORMATION FOR SEQ ID NO:695: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 17 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:695: ATGGAGGGCG GCATGGC 17 (2) INFORMATION FOR SEQ ID NO:696: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 16 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:696: ATGGAGGGCG GCATGG 16 (2) INFORMATION FOR SEQ ID NO:697: WO 00/09525 PCT/US99/17712 EPI-109 354 (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:697: ATGGAGGGCG GCATG 15 (2) INFORMATION FOR SEQ ID NO:698: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:698: ATGGAGGGCG GCAT 14 (2) INFORMATION FOR SEQ ID NO:699: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 13 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:699: ATGGAGGGCG GCA 13 (2) INFORMATION FOR SEQ ID NO:700: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 12 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:700: ATGGAGGGCG GC 12 (2) INFORMATION FOR SEQ ID NO:701: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 11 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:701: ATGGAGGGCG G 11 (2) INFORMATION FOR SEQ ID NO:702: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 10 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:702: ATGGAGGGCG 10 (2) INFORMATION FOR SEQ ID NO:703: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 31 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:703: TGGAGGGCGG CATGGCGGGC ACAGGCTGGG C 31 (2) INFORMATION FOR SEQ ID NO:704: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 30 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:704: TGGAGGGCGG CATGGCGGGC ACAGGCTGGG 30 (2) INFORMATION FOR SEQ ID NO:705: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 29 base pairs (B) TYPE: nucleic acid WO 00/09525 PCTUS99/17712 EPI-109 355 (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:705: TGGAGGGCGG CATGGCGGGC ACAGGCTGG 29 (2) INFORMATION FOR SEQ ID NO:706: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 28 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:706: TGGAGGGCGG CATGGCGGGC ACAGGCTG 28 (2) INFORMATION FOR SEQ ID NO:707: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 27 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:707: TGGAGGGCGG CATGGCGGGC ACAGGCT 27 (2) INFORMATION FOR SEQ ID NO:708: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 26 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:708: TGGAGGGCGG CATGGCGGGC ACAGGC 26 (2) INFORMATION FOR SEQ ID NO:709: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 25 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:709: TGGAGGGCGG CATGGCGGGC ACAGG 25 (2) INFORMATION FOR SEQ ID NO:710: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 24 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:710: TGGAGGGCGG CATGGCGGGC ACAG 24 (2) INFORMATION FOR SEQ ID NO:711: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 23 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:711: TGGAGGGCGG CATGGCGGGC ACA 23 (2) INFORMATION FOR SEQ ID NO:712: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:712: TGGAGGGCGG CATGGCGGGC AC 22 (2) INFORMATION FOR SEQ ID NO:713: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 21 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:713: WO 00/09525 PCT/US99/17712 EPI-109 356 TGGAGGGCGG CATGGCGGGC A 21 (2) INFORMATION FOR SEQ ID NO:714: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 20 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:714: TGGAGGGCGG CATGGCGGGC 20 (2) INFORMATION FOR SEQ ID NO:715: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:715: TGGAGGGCGG CATGGCGGG 19 (2) INFORMATION FOR SEQ ID NO:716: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:716: TGGAGGGCGG CATGGCGG 18 (2) INFORMATION FOR SEQ ID NO:717: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 17 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:717: TGGAGGGCGG CATGGCG 17 (2) INFORMATION FOR SEQ ID NO:718: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 16 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:718: TGGAGGGCGG CATGGC 16 (2) INFORMATION FOR SEQ ID NO:719: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:719: TGGAGGGCGG CATGG 15 (2) INFORMATION FOR SEQ ID NO:720: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:720: TGGAGGGCGG CATG 14 (2) INFORMATION FOR SEQ ID NO:721: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 13 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:721: TGGAGGGCGG CAT 13 (2) INFORMATION FOR SEQ ID NO:722: WO 00/09525 PCT/US99/17712 EPI-109 357 (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 12 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:722: TGGAGGGCGG CA 12 (2) INFORMATION FOR SEQ ID NO:723: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 11 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:723: TGGAGGGCGG C 11 (2) INFORMATION FOR SEQ ID NO:724: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 10 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:724: TGGAGGGCGG 10 (2) INFORMATION FOR SEQ ID NO:725: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 30 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:725: GGAGGGCGGC ATGGCGGGCA CAGGCTGGGC 30 (2) INFORMATION FOR SEQ ID NO:726: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 29 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:726: GGAGGGCGGC ATGGCGGGCA CAGGCTGGG 29 (2) INFORMATION FOR SEQ ID NO:727: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 28 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:727: GGAGGGCGGC ATGGCGGGCA CAGGCTGG 28 (2) INFORMATION FOR SEQ ID NO:728: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 27 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:728: GGAGGGCGGC ATGGCGGGCA CAGGCTG 27 (2) INFORMATION FOR SEQ ID NO:729: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 26 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:729: GGAGGGCGGC ATGGCGGGCA CAGGCT 26 (2) INFORMATION FOR SEQ ID NO:730: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 25 base pairs (B) TYPE: nucleic acid WO 00/09525 PCT/US99/17712 EPI-109 358 (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:730: GGAGGGCGGC ATGGCGGGCA CAGGC 25 (2) INFORMATION FOR SEQ ID NO:731: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 24 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:731: GGAGGGCGGC ATGGCGGGCA CAGG 24 (2) INFORMATION FOR SEQ ID NO:732: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 23 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:732: GGAGGGCGGC ATGGCGGGCA CAG 23 (2) INFORMATION FOR SEQ ID NO:733: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:733: GGAGGGCGGC ATGGCGGGCA CA 22 (2) INFORMATION FOR SEQ ID NO:734: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 21 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:734: GGAGGGCGGC ATGGCGGGCA C 21 (2) INFORMATION FOR SEQ ID NO:735: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 20 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:735: GGAGGGCGGC ATGGCGGGCA 20 (2) INFORMATION FOR SEQ ID NO:736: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:736: GGAGGGCGGC ATGGCGGGC 19 (2) INFORMATION FOR SEQ ID NO:737: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:737: GGAGGGCGGC ATGGCGGG 18 (2) INFORMATION FOR SEQ ID NO:738: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 17 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:738: WO 00/09525 PCT/US99/17712 EPI-109 359 GGAGGGCGGC ATGGCGG 17 (2) INFORMATION FOR SEQ ID NO:739: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 16 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear. (xi) SEQUENCE DESCRIPTION: SEQ ID NO:739: GGAGGGCGGC ATGGCG 16 (2) INFORMATION FOR SEQ ID NO:740: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:740: GGAGGGCGGC ATGGC 15 (2) INFORMATION FOR SEQ ID NO:741: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:741: GGAGGGCGGC ATGG 14 (2) INFORMATION FOR SEQ ID NO:742: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 13 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:742: GGAGGGCGGC ATG 13 (2) INFORMATION FOR SEQ ID NO:743: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 12 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:743: GGAGGGCGGC AT 12 (2) INFORMATION FOR SEQ ID NO:744: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 11 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:744: GGAGGGCGGC A 11 (2) INFORMATION FOR SEQ ID NO:745: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 10 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:745: GGAGGGCGGC 10 (2) INFORMATION FOR SEQ ID NO:746: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 29 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:746: GAGGGCGGCA TGGCGGGCAC AGGCTGGGC 29 (2) INFORMATION FOR SEQ ID NO:747: WO 00/09525 PCT/US99/17712 EPI-109 360 (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 28 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:747: GAGGGCGGCA TGGCGGGCAC AGGCTGGG 28 (2) INFORMATION FOR SEQ ID NO:748: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 27 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:748: GAGGGCGGCA TGGCGGGCAC AGGCTGG 27 (2) INFORMATION FOR SEQ ID NO:749: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 26 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:749: GAGGGCGGCA TGGCGGGCAC AGGCTG 26 (2) INFORMATION FOR SEQ ID NO:750: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 25 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:750: GAGGGCGGCA TGGCGGGCAC AGGCT 25 (2) INFORMATION FOR SEQ ID NO:751: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 24 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:751: GAGGGCGGCA TGGCGGGCAC AGGC 24 (2) INFORMATION FOR SEQ ID NO:752: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 23 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:752: GAGGGCGGCA TGGCGGGCAC AGG 23 (2) INFORMATION FOR SEQ ID NO:753: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:753: GAGGGCGGCA TGGCGGGCAC AG 22 (2) INFORMATION FOR SEQ ID NO:754: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 21 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:754: GAGGGCGGCA TGGCGGGCAC A 21 (2) INFORMATION FOR SEQ ID NO:755: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 20 base pairs (B) TYPE: nucleic acid WO 00/09525 PCT/US99/17712 EPI-109 361 (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:755: GAGGGCGGCA TGGCGGGCAC 20 (2) INFORMATION FOR SEQ ID NO:756: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:756: GAGGGCGGCA TGGCGGGCA 19 (2) INFORMATION FOR SEQ ID NO:757: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:757: GAGGGCGGCA TGGCGGGC 18 (2) INFORMATION FOR SEQ ID NO:758: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 17 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:758: GAGGGCGGCA TGGCGGG 17 (2) INFORMATION FOR SEQ ID NO:759: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 16 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:759: GAGGGCGGCA TGGCGG 16 (2) INFORMATION FOR SEQ ID NO:760: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:760: GAGGGCGGCA TGGCG 15 (2) INFORMATION FOR SEQ ID NO:761: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:761: GAGGGCGGCA TGGC 14 (2) INFORMATION FOR SEQ ID NO:762: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 13 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:762: GAGGGCGGCA TGG 13 (2) INFORMATION FOR SEQ ID NO:763: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 12 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:763: WO 00/09525 PCT/US99/17712 EPI-109 362 GAGGGCGGCA TG 12 (2) INFORMATION FOR SEQ ID NO:764: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 11 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:764: GAGGGCGGCA T 11 (2) INFORMATION FOR SEQ ID NO:765: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 10 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:765: GAGGGCGGCA 10 (2) INFORMATION FOR SEQ ID NO:766: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 28 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:766: AGGGCGGCAT GGCGGGCACA GGCTGGGC 28 (2) INFORMATION FOR SEQ ID NO:767: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 27 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:767: AGGGCGGCAT GGCGGGCACA GGCTGGG 27 (2) INFORMATION FOR SEQ ID NO:768: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 26 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:768: AGGGCGGCAT GGCGGGCACA GGCTGG 26 (2) INFORMATION FOR SEQ ID NO:769: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 25 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:769: AGGGCGGCAT GGCGGGCACA GGCTG 25 (2) INFORMATION FOR SEQ ID NO:770: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 24 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:770: AGGGCGGCAT GGCGGGCACA GGCT 24 (2) INFORMATION FOR SEQ ID NO:771: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 23 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:771: AGGGCGGCAT GGCGGGCACA GGC 23 (2) INFORMATION FOR SEQ ID NO:772: WO 00/09525 PCT/US99/17712 EPI-109 363 (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:772: AGGGCGGCAT GGCGGGCACA GG 22 (2) INFORMATION FOR SEQ ID NO:773: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 21 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:773: AGGGCGGCAT GGCGGGCACA G 21 (2) INFORMATION FOR SEQ ID NO:774: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 20 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:774: AGGGCGGCAT GGCGGGCACA 20 (2) INFORMATION FOR SEQ ID NO:775: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:775: AGGGCGGCAT GGCGGGCAC 19 (2) INFORMATION FOR SEQ ID NO:776: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:776: AGGGCGGCAT GGCGGGCA 18 (2) INFORMATION FOR SEQ ID NO:777: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 17 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:777: AGGGCGGCAT GGCGGGC 17 (2) INFORMATION FOR SEQ ID NO:778: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 16 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:778: AGGGCGGCAT GGCGGG 16 (2) INFORMATION FOR SEQ ID NO:779: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:779: AGGGCGGCAT GGCGG 15 (2) INFORMATION FOR SEQ ID NO:780: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid WO 00/09525 PCT/US99/17712 EPI-109 364 (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:780: AGGGCGGCAT GGCG 14 (2) INFORMATION FOR SEQ ID NO:781: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 13 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:781: AGGGCGGCAT GGC 13 (2) INFORMATION FOR SEQ ID NO:782: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 12 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:782: AGGGCGGCAT GG 12 (2) INFORMATION FOR SEQ ID NO:783: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 11 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:783: AGGGCGGCAT G 11 (2) INFORMATION FOR SEQ ID NO:784: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 10 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:784: AGGGCGGCAT 10 (2) INFORMATION FOR SEQ ID NO:785: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 27 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:785: GGGCGGCATG GCGGGCACAG GCTGGGC 27 (2) INFORMATION FOR SEQ ID NO:786: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 26 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:786: GGGCGGCATG GCGGGCACAG GCTGGG 26 (2) INFORMATION FOR SEQ ID NO:787: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 25 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:787: GGGCGGCATG GCGGGCACAG GCTGG 25 (2) INFORMATION FOR SEQ ID NO:788: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 24 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:788: WO 00/09525 PCT/US99/17712 EPI-109 365 GGGCGGCATG GCGGGCACAG GCTG 24 (2) INFORMATION FOR SEQ ID NO:789: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 23 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:789: GGGCGGCATG GCGGGCACAG GCT 23 (2) INFORMATION FOR SEQ ID NO:790: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:790: GGGCGGCATG GCGGGCACAG GC 22 (2) INFORMATION FOR SEQ ID NO:791: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 21 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:791: GGGCGGCATG GCGGGCACAG G 21 (2) INFORMATION FOR SEQ ID NO:792: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 20 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:792: GGGCGGCATG GCGGGCACAG 20 (2) INFORMATION FOR SEQ ID NO:793: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:793: GGGCGGCATG GCGGGCACA 19 (2) INFORMATION FOR SEQ ID NO:794: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:794: GGGCGGCATG GCGGGCAC 18 (2) INFORMATION FOR SEQ ID NO:795: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 17 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:795: GGGCGGCATG GCGGGCA 17 .(2) INFORMATION FOR SEQ ID NO:796: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 16 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:796: GGGCGGCATG GCGGGC 16 (2) INFORMATION FOR SEQ ID NO:797: WO 00/09525 PCT/US99/17712 EPI-109 366 (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:797: GGGCGGCATG GCGGG 15 (2) INFORMATION FOR SEQ ID NO:798: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:798: GGGCGGCATG GCGG 14 (2) INFORMATION FOR SEQ ID NO:799: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 13 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:799: GGGCGGCATG GCG 13 (2) INFORMATION FOR SEQ ID NO:800: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 12 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:800: GGGCGGCATG GC 12 (2) INFORMATION FOR SEQ ID NO:801: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 11 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:801: GGGCGGCATG G 11 (2) INFORMATION FOR SEQ ID NO:802: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 10 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:802: GGGCGGCATG 10 (2) INFORMATION FOR SEQ ID NO:803: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 26 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:803: GGCGGCATGG CGGGCACAGG CTGGGC 26 (2) INFORMATION FOR SEQ ID NO:804: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 25 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:804: GGCGGCATGG CGGGCACAGG CTGGG 25 (2) INFORMATION FOR SEQ ID NO:805: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 24 base pairs (B) TYPE: nucleic acid WO 00/09525 PCT/US99/17712 EPI-109 367 (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:805: GGCGGCATGG CGGGCACAGG CTGG 24 (2) INFORMATION FOR SEQ ID NO:806: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 23 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:806: GGCGGCATGG CGGGCACAGG CTG 23 (2) INFORMATION FOR SEQ ID NO:807: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:807: GGCGGCATGG CGGGCACAGG CT 22 (2) INFORMATION FOR SEQ ID NO:808: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 21 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:808: GGCGGCATGG CGGGCACAGG C 21 (2) INFORMATION FOR SEQ ID NO:809: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 20 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:809: GGCGGCATGG CGGGCACAGG 20 (2) INFORMATION FOR SEQ ID NO:810: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:810: GGCGGCATGG CGGGCACAG 19 (2) INFORMATION FOR SEQ ID NO:811: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:811: GGCGGCATGG CGGGCACA 18 (2) INFORMATION FOR SEQ ID NO:812: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 17 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:812: GGCGGCATGG CGGGCAC 17 (2) INFORMATION FOR SEQ ID NO:813: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 16 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:813: WO 00/09525 PCT/US99/17712 EPI-109 368 GGCGGCATGG CGGGCA 16 (2) INFORMATION FOR SEQ ID NO:814: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:814: GGCGGCATGG CGGGC 15 (2) INFORMATION FOR SEQ ID NO:815: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:815: GGCGGCATGG CGGG 14 (2) INFORMATION FOR SEQ ID NO:816: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 13 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:816: GGCGGCATGG CGG 13 (2) INFORMATION FOR SEQ ID NO:817: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 12 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:817: GGCGGCATGG CG 12 (2) INFORMATION FOR SEQ ID NO:818: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 11 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:818: GGCGGCATGG C 11 (2) INFORMATION FOR SEQ ID NO:819: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 10 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:819: GGCGGCATGG 10 (2) INFORMATION FOR SEQ ID NO:820: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 25 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:820: GCGGCATGGC GGGCACAGGC TGGGC 25 (2) INFORMATION FOR SEQ ID NO:821: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 24 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:821: GCGGCATGGC GGGCACAGGC TGGG 24 (2) INFORMATION FOR SEQ ID NO:822: WO 00/09525 PCT/US99/17712 EPI-109 369 (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 23 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:822: GCGGCATGGC GGGCACAGGC TGG 23 (2) INFORMATION FOR SEQ ID NO:823: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:823: GCGGCATGGC GGGCACAGGC TG 22 (2) INFORMATION FOR SEQ ID NO:824: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 21 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:824: GCGGCATGGC GGGCACAGGC T 21 (2) INFORMATION FOR SEQ ID NO:825: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 20 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:825: GCGGCATGGC GGGCACAGGC 20 (2) INFORMATION FOR SEQ ID NO:826: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:826: GCGGCATGGC GGGCACAGG 19 (2) INFORMATION FOR SEQ ID NO:827: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:827: GCGGCATGGC GGGCACAG 18 (2) INFORMATION FOR SEQ ID NO:828: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 17 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:828: GCGGCATGGC GGGCACA 17 (2) INFORMATION FOR SEQ ID NO:829: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 16 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:829: GCGGCATGGC GGGCAC 16 (2) INFORMATION FOR SEQ ID NO:830: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid WO 00/09525 PCT/US99/17712 EPI-109 370 (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:830: GCGGCATGGC GGGCA 15 (2) INFORMATION FOR SEQ ID NO:831: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:831: GCGGCATGGC GGGC 14 (2) INFORMATION FOR SEQ ID NO:832: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 13 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:832: GCGGCATGGC GGG 13 (2) INFORMATION FOR SEQ ID NO:833: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 12 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:833: GCGGCATGGC GG 12 (2) INFORMATION FOR SEQ ID NO:834: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 11 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:834: GCGGCATGGC G 11 (2) INFORMATION FOR SEQ ID NO:835: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 10 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:835: GCGGCATGGC 10 (2) INFORMATION FOR SEQ ID NO:836: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 24 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:836: CGGCATGGCG GGCACAGGCT GGGC 24 (2) INFORMATION FOR SEQ ID NO:837: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 23 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:837: CGGCATGGCG GGCACAGGCT GGG 23 (2) INFORMATION FOR SEQ ID NO:838: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:838: WO 00/09525 PCT/US99/17712 EPI-109 371 CGGCATGGCG GGCACAGGCT GG 22 (2) INFORMATION FOR SEQ ID NO:839: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 21 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:839: CGGCATGGCG GGCACAGGCT G 21 (2) INFORMATION FOR SEQ ID NO:840: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 20 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:840: CGGCATGGCG GGCACAGGCT 20 (2) INFORMATION FOR SEQ ID NO:841: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:841: CGGCATGGCG GGCACAGGC 19 (2) INFORMATION FOR SEQ ID NO:842: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:842: CGGCATGGCG GGCACAGG 18 (2) INFORMATION FOR SEQ ID NO:843: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 17 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:843: CGGCATGGCG GGCACAG 17 (2) INFORMATION FOR SEQ ID NO:844: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 16 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:844: CGGCATGGCG GGCACA 16 (2) INFORMATION FOR SEQ ID NO:845: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:845: CGGCATGGCG GGCAC 15 -(2) INFORMATION FOR SEQ ID NO:846: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:846: CGGCATGGCG GGCA 14 (2) INFORMATION FOR SEQ ID NO:847: WO 00/09525 PCTIUS99/17712 EPI-109 372 (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 13 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:847: CGGCATGGCG GGC 13 (2) INFORMATION FOR SEQ ID NO:848: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 12 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:848: CGGCATGGCG GG 12 (2) INFORMATION FOR SEQ ID NO:849: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 11 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:849: CGGCATGGCG G 11 (2) INFORMATION FOR SEQ ID NO:850: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 10 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:850: CGGCATGGCG 10 (2) INFORMATION FOR SEQ ID NO:851: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 23 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:851: GGCATGGCGG GCACAGGCTG GGC 23 (2) INFORMATION FOR SEQ ID NO:852: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:852: GGCATGGCGG GCACAGGCTG GG 22 (2) INFORMATION FOR SEQ ID NO:853: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 21 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:853: GGCATGGCGG GCACAGGCTG G 21 (2) INFORMATION FOR SEQ ID NO:854: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 20 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:854: GGCATGGCGG GCACAGGCTG 20 (2) INFORMATION FOR SEQ ID NO:855: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 base pairs (B) TYPE: nucleic acid WO 00/09525 PCT/US99/17712 EPI-109 373 (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:855: GGCATGGCGG GCACAGGCT 19 (2) INFORMATION FOR SEQ ID NO:856: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:856: GGCATGGCGG GCACAGGC 18 (2) INFORMATION FOR SEQ ID NO:857: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 17 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:857: GGCATGGCGG GCACAGG 17 (2) INFORMATION FOR SEQ ID NO:858: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 16 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:858: GGCATGGCGG GCACAG 16 (2) INFORMATION FOR SEQ ID NO:859: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:859: GGCATGGCGG GCACA 15 (2) INFORMATION FOR SEQ ID NO:860: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:860: GGCATGGCGG GCAC 14 (2) INFORMATION FOR SEQ ID NO:861: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 13 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:861: GGCATGGCGG GCA 13 (2) INFORMATION FOR SEQ ID NO:862: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 12 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:862: GGCATGGCGG GC 12 (2) INFORMATION FOR SEQ ID NO:863: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 11 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:863: WO 00/09525 PCT/US99/17712 EPI-109 374 GGCATGGCGG G 11 (2) INFORMATION FOR SEQ ID NO:864: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 10 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:864: GGCATGGCGG 10 (2) INFORMATION FOR SEQ ID NO:865: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:865: GCATGGCGGG CACAGGCTGG GC 22 (2) INFORMATION FOR SEQ ID NO:866: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 21 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:866: GCATGGCGGG CACAGGCTGG G 21 (2) INFORMATION FOR SEQ ID NO:867: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 20 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:867: GCATGGCGGG CACAGGCTGG 20 (2) INFORMATION FOR SEQ ID NO:868: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear ' (xi) SEQUENCE DESCRIPTION: SEQ ID NO:868: GCATGGCGGG CACAGGCTG 19 (2) INFORMATION FOR SEQ ID NO:869: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:869: GCATGGCGGG CACAGGCT 18 (2) INFORMATION FOR SEQ ID NO:870: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 17 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:870: GCATGGCGGG CACAGGC 17 (2) INFORMATION FOR SEQ ID NO:871: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 16 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:871: GCATGGCGGG CACAGG 16 (2) INFORMATION FOR SEQ ID NO:872: WO 00/09525 PCT/US99/17712 EPI-109 375 (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:872: GCATGGCGGG CACAG 15 (2) INFORMATION FOR SEQ ID NO:873: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:873: GCATGGCGGG CACA 14 (2) INFORMATION FOR SEQ ID NO:874: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 13 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:874: GCATGGCGGG CAC 13 (2) INFORMATION FOR SEQ ID NO:875: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 12 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:875: GCATGGCGGG CA 12 (2) INFORMATION FOR SEQ ID NO:876: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 11 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:876: GCATGGCGGG C 11 (2) INFORMATION FOR SEQ ID NO:877: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 10 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:877: GCATGGCGGG 10 (2) INFORMATION FOR SEQ ID NO:878: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 21 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:878: CATGGCGGGC ACAGGCTGGG C 21 (2) INFORMATION FOR SEQ ID NO:879: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 20 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:879: CATGGCGGGC ACAGGCTGGG 20 (2) INFORMATION FOR SEQ ID NO:880: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 base pairs (B) TYPE: nucleic acid WO 00/09525 PCT/US99/17712 EPI-109 376 (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:880: CATGGCGGGC ACAGGCTGG 19 (2) INFORMATION FOR SEQ ID NO:881: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:881: CATGGCGGGC ACAGGCTG 18 (2) INFORMATION FOR SEQ ID NO:882: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 17 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:882: CATGGCGGGC ACAGGCT 17 (2) INFORMATION FOR SEQ ID NO:883: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 16 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:883: CATGGCGGGC ACAGGC 16 (2) INFORMATION FOR SEQ ID NO:884: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:884: CATGGCGGGC ACAGG 15 (2) INFORMATION FOR SEQ ID NO:885: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:885: CATGGCGGGC ACAG 14 (2) INFORMATION FOR SEQ ID NO:886: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 13 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:886: CATGGCGGGC ACA 13 (2) INFORMATION FOR SEQ ID NO:887: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 12 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:887: CATGGCGGGC AC 12 (2) INFORMATION FOR SEQ ID NO:888: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 11 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:888: WO 00/09525 PCT/US99/17712 EPI-109 377 CATGGCGGGC A 11 (2) INFORMATION FOR SEQ ID NO:889: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 10 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:889: CATGGCGGGC 10 (2) INFORMATION FOR SEQ ID NO:890: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 20 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:890: ATGGCGGGCA CAGGCTGGGC 20 (2) INFORMATION FOR SEQ ID NO:891: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:891: ATGGCGGGCA CAGGCTGGG 19 (2) INFORMATION FOR SEQ ID NO:892: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:892: ATGGCGGGCA CAGGCTGG 18 (2) INFORMATION FOR SEQ ID NO:893: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 17 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:893: ATGGCGGGCA CAGGCTG 17 (2) INFORMATION FOR SEQ ID NO:894: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 16 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:894: ATGGCGGGCA CAGGCT 16 (2) INFORMATION FOR SEQ ID NO:895: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:895: ATGGCGGGCA CAGGC 15 (2) INFORMATION FOR SEQ ID NO:896: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:896: ATGGCGGGCA CAGG 14 (2) INFORMATION FOR SEQ ID NO:897: WO 00/09525 PCTIUS99/17712 EPI-109 378 (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 13 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:897: ATGGCGGGCA CAG 13 (2) INFORMATION FOR SEQ ID NO:898: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 12 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:898: ATGGCGGGCA CA 12 (2) INFORMATION FOR SEQ ID NO:899: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 11 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:899: ATGGCGGGCA C 11 (2) INFORMATION FOR SEQ ID NO:900: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 10 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:900: ATGGCGGGCA 10 (2) INFORMATION FOR SEQ ID NO:901: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:901: TGGCGGGCAC AGGCTGGGC 19 (2) INFORMATION FOR SEQ ID NO:902: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:902: TGGCGGGCAC AGGCTGGG 18 (2) INFORMATION FOR SEQ ID NO:903: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 17 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:903: TGGCGGGCAC AGGCTGG 17 (2) INFORMATION FOR SEQ ID NO:904: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 16 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:904: TGGCGGGCAC AGGCTG 16 (2) INFORMATION FOR SEQ ID NO:905: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid WO 00/09525 PCT/US99/17712 EPI-109 379 (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:905: TGGCGGGCAC AGGCT 15 (2) INFORMATION FOR SEQ ID NO:906: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:906: TGGCGGGCAC AGGC 14 (2) INFORMATION FOR SEQ ID NO:907: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 13 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:907: TGGCGGGCAC AGG 13 (2) INFORMATION FOR SEQ ID NO:908: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 12 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear ' (xi) SEQUENCE DESCRIPTION: SEQ ID NO:908: TGGCGGGCAC AG 12 (2) INFORMATION FOR SEQ ID NO:909: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 11 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:909: TGGCGGGCAC A 11 (2) INFORMATION FOR SEQ ID NO:910: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 10 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:910: TGGCGGGCAC 10 (2) INFORMATION FOR SEQ ID NO:911: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:911: GGCGGGCACA GGCTGGGC 18 (2) INFORMATION FOR SEQ ID NO:912: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 17 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:912: GGCGGGCACA GGCTGGG 17 (2) INFORMATION FOR SEQ ID NO:913: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 16 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:913: WO 00/09525 PCT/US99/17712 EPI-109 380 GGCGGGCACA GGCTGG 16 (2) INFORMATION FOR SEQ ID NO:914: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:914: GGCGGGCACA GGCTG 15 (2) INFORMATION FOR SEQ ID NO:915: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:915: GGCGGGCACA GGCT 14 (2) INFORMATION FOR SEQ ID NO:916: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 13 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:916: GGCGGGCACA GGC 13 (2) INFORMATION FOR SEQ ID NO:917: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 12 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:917: GGCGGGCACA GG 12 (2) INFORMATION FOR SEQ ID NO:918: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 11 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:918: GGCGGGCACA G 11 (2) INFORMATION FOR SEQ ID NO:919: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 10 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:919: GGCGGGCACA 10 (2) INFORMATION FOR SEQ ID NO:920: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 17 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:920: GCGGGCACAG GCTGGGC 17 (2) INFORMATION FOR SEQ ID NO:921: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 16 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:921: GCGGGCACAG GCTGGG 16 (2) INFORMATION FOR SEQ ID NO:922: WO 00/09525 PCT/US99/17712 EPI-109 381 (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:922: GCGGGCACAG GCTGG 15 (2) INFORMATION FOR SEQ ID NO:923: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:923: GCGGGCACAG GCTG 14 (2) INFORMATION FOR SEQ ID NO:924: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 13 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:924: GCGGGCACAG GCT 13 (2) INFORMATION FOR SEQ ID NO:925: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 12 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:925: GCGGGCACAG GC 12 (2) INFORMATION FOR SEQ ID NO:926: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 11 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:926: GCGGGCACAG G 11 (2) INFORMATION FOR SEQ ID NO:927: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 10 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:927: GCGGGCACAG 10 (2) INFORMATION FOR SEQ ID NO:928: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 16 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:928: CGGGCACAGG CTGGGC 16 (2) INFORMATION FOR SEQ ID NO:929: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:929: GGGCACAGGC TGGG 14 (2) INFORMATION FOR SEQ ID NO:930: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs WO 00/09525 PCT/US99/17712 EPI-109 382 (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:930: CGGGCACAGG CTGG 14 (2) INFORMATION FOR SEQ ID NO:931: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 13 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:931: CGGGCACAGG CTG 13 (2) INFORMATION FOR SEQ ID NO:932: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 12 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:932: CGGGCACAGG CT 12 (2) INFORMATION FOR SEQ ID NO:933: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 11 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:933: CGGGCACAGG C 11 (2) INFORMATION FOR SEQ ID NO:934: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 10 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:934: CGGGCACAGG 10 (2) INFORMATION FOR SEQ ID NO:935: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:935: GGGCACAGGC TGGGC 15 (2) INFORMATION FOR SEQ ID NO:936: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:936: GGGCACAGGC TGGG 14 (2) INFORMATION FOR SEQ ID NO:937: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 13 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:937: GGGCACAGGC TGG 13 (2) INFORMATION FOR SEQ ID NO:938: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 12 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear WO 00/09525 PCT/US99/17712 EPI-109 383 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:938: GGGCACAGGC TG 12 (2) INFORMATION FOR SEQ ID NO:939: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 11 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:939: GGGCACAGGC T 11 (2) INFORMATION FOR SEQ ID NO:940: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 10 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:940: GGGCACAGGC 10 (2) INFORMATION FOR SEQ ID NO:941: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:941: GGCACAGGCT GGGC 14 (2) INFORMATION FOR SEQ ID NO:942: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 13 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:942: GGCACAGGCT GGG 13 (2) INFORMATION FOR SEQ ID NO:943: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 12 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:943: GGCACAGGCT GG 12 (2) INFORMATION FOR SEQ ID NO:944: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 11 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:944: GGCACAGGCT G 11 (2) INFORMATION FOR SEQ ID NO:945: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 10 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:945: GGCACAGGCT 10 (2) INFORMATION FOR SEQ ID NO:946: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 13 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:946: GCACAGGCTG GGC 13 WO 00/09525 PCT/US99/17712 EPI-109 384 (2) INFORMATION FOR SEQ ID NO:947: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 12 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:947: GCACAGGCTG GG 12 (2) INFORMATION FOR SEQ ID NO:948: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 11 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:948: GCACAGGCTG G 11 (2) INFORMATION FOR SEQ ID NO:949: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 10 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:949: GCACAGGCTG 10 (2) INFORMATION FOR SEQ ID NO:950: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 12 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:950: CACAGGCTGG GC 12 (2) INFORMATION FOR SEQ ID NO:951: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 11 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:951: CACAGGCTGG G 11 (2) INFORMATION FOR SEQ ID NO:952: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 10 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:952: CACAGGCTGG 10 (2) INFORMATION FOR SEQ ID NO:953: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 11 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:953: ACAGGCTGGG C 11 (2) INFORMATION FOR SEQ ID NO:954: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 10 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:954: ACAGGCTGGG 10 (2) INFORMATION FOR SEQ ID NO:955: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 10 base pairs WO 00/09525 PCT/US99/17712 EPI-109 385 (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:955: CAGGCTGGGC 10 (2) INFORMATION FOR SEQ ID NO:956: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 23 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:956: TTTTCCTTCC TTTGTCTCTC TTC 23 (2) INFORMATION FOR SEQ ID NO:957: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:957: GCTCCCGGCT GCCTG 15 (2) INFORMATION FOR SEQ ID NO:958: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 29 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:958: CTCGGCCGTG CGGCTCTGTC GCTCCCGGT 29 (2) INFORMATION FOR SEQ ID NO:959: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 20 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:959: CCGCCGCCCT CCGGGGGGTC 20 (2) INFORMATION FOR SEQ ID NO:960: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:960: TGCTGCCGTT GGCTGCCC 18 (2) INFORMATION FOR SEQ ID NO:961: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 17 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:961: CTTCTGCGGG TCGCCGG 17 (2) INFORMATION FOR SEQ ID NO:962: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:962: TGCTGGGCTT GTGGC 15 (2) INFORMATION FOR SEQ ID NO:963: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear WO 00/09525 PCT/US99/17712 EPI-109 386 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:963: GGCCTCTCTT CTGGG 15 (2) INFORMATION FOR SEQ ID NO:964: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:964: CCTGGTCCCT CCGT 14 (2) INFORMATION FOR SEQ ID NO:965: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:965: GGTGGCTCCT CTGC 14 (2) INFORMATION FOR SEQ ID NO:966: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:966: GCTTGGTCCT GGGGCTGC 18 (2) INFORMATION FOR SEQ ID NO:967: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:967: TGCTCTCCTC TCCTT 15 (2) INFORMATION FOR SEQ ID NO:968: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 21 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:968: TGCTTTTCTT TTCTGGGCCT C 21 (2) INFORMATION FOR SEQ ID NO:969: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:969: TGTGGTCTGT TTTTTTCTG 19 (2) INFORMATION FOR SEQ ID NO:970: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 20 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:970: GCCCTGCTGG GGCGCTCTCC 20 (2) INFORMATION FOR SEQ ID NO:971: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:971: GCCGCCCGCC TGGCTCCC 18 WO 00/09525 PCTIUS99/17712 EPI-109 387 (2) INFORMATION FOR SEQ ID NO:972: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 21 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: Genomic DNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:972: GGBGCCCBTG BTGGGCBTGC C 21 (2) INFORMATION FOR SEQ ID NO:973: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 24 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:973: GTGGTTCTTG CCCTCCTTTG GCTG 24 (2) INFORMATION FOR SEQ ID NO:974: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:974: CCGTGCCCGC TCCCCGGC 18 (2) INFORMATION FOR SEQ ID NO:975: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 20 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:975: CTCCTGGCGG GTGGCCGTTG 20 (2) INFORMATION FOR SEQ ID NO:976: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:976: GGCCCGTGTT CCCCTGGG 18 (2) INFORMATION FOR SEQ ID NO:977: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 20 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:977: GCCTGGGGCT CCCTTCTCTC 20 (2) INFORMATION FOR SEQ ID NO:978: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:978: GCCCTTCTTG CTGGGCCTC 19 (2) INFORMATION FOR SEQ ID NO:979: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 25 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:979: TGCTGCTGCT GGTGCTGTGG CCCCC 25 (2) INFORMATION FOR SEQ ID NO:980: (i) SEQUENCE CHARACTERISTICS: WO 00/09525 PCT/US99/17712 EPI-109 388 (A) LENGTH: 43 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:980: GTACACCGAG GAGCCCATGA TGGGCATGCC ACAGACGACA GGC 43 (2) INFORMATION FOR SEQ ID NO:981: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 43 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: Genomic DNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:981: GTBCBCCGBG GBGCCCBTGB TGGGCBTGCC BCBGBCGBCB GGC 43 (2) INFORMATION FOR SEQ ID NO:982: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 29 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:982: GGCGCCGTGC CGCGTCTTGG TGGCGGCGG 29 (2) INFORMATION FOR SEQ ID NO:983: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 30 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:983: GTTCGCGCCC GCGCGGGGCC CCTCCGGTCC 30 (2) INFORMATION FOR SEQ ID NO:984: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 30 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:984: GTTCGCGCCC GCGCGGGGCC CCTCCGGTCC 30 (2) INFORMATION FOR SEQ ID NO:985: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:985: CGGGTCGGGG CCCCCCGCGG CC 22 (2) INFORMATION FOR SEQ ID NO:986: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 29 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:986: GCCTCGGGGC TGGGGCGCTG GTGGCCGGG 29 (2) INFORMATION FOR SEQ ID NO:987: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 24 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:987: CCGCGCCTCC GCCTGCCGCT TCTG 24 (2) INFORMATION FOR SEQ ID NO:988: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 21 base pairs (B) TYPE: nucleic acid WO 00/09525 PCT/US99/17712 EPI-109 389 (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:988: GCTGGGCCCC GGGCGCCCCC T 21 (2) INFORMATION FOR SEQ ID NO:989: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 23 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:989: CCCCTCTTGC TCGGGTCCCC GTG 23 (2) INFORMATION FOR SEQ ID NO:990: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 48 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:990: ACAGCGCGTC CTGTGTCTCC AGCAGCATGG CCGGGCCAGC TGGGCCCC 48 (2) INFORMATION FOR SEQ ID NO:991: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 48 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: Genomic DNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:991: BCBGCGCGTC CTGTGTCTCC BGCBGCBTGG CCGGGCCBGC TGGGCCCC 48 (2) INFORMATION FOR SEQ ID NO:992: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 39 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:992: ACAGAGCATG CTGTTGTTGG GCATCTTGCC TTCCCAGGG 39 (2) INFORMATION FOR SEQ ID NO:993: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 39 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: Genomic DNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:993: BCBGBGCBTG CTGTTGTTGG GCBTCTTGCC TTCCCBGGG 39 (2) INFORMATION FOR SEQ ID NO:994: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:994: CCCTTTTCTG GTGGGGTG 18 (2) INFORMATION FOR SEQ ID NO:995: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:995: GTGCTGTTGT TGGGC 15 (2) INFORMATION FOR SEQ ID NO:996: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single WO 00/09525 PCTIUS99/17712 EPI-109 390 (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:996: TTTCTTCTGT TCCC 14 (2) INFORMATION FOR SEQ ID NO:997: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:997: CCCTTTTCTG GTGGGGTG 18 (2) INFORMATION FOR SEQ ID NO:998: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:998: GTGCTGTTGT TGGGC 15 (2) INFORMATION FOR SEQ ID NO:999: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:999: TTTCTTCTGT TCCC 14 (2) INFORMATION FOR SEQ ID NO:1000: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 17 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1000: TTTCCCCTGG GTCTTCC 17 (2) INFORMATION FOR SEQ ID NO:1001: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 16 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1001: CTCCTGCTCT TTTTTC 16 (2) INFORMATION FOR SEQ ID NO:1002: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 50 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1002: ATTTGCTCTC CTATTACTTT CTGTGTCCAT TTTTTCATTA ACCGAGCTGT 50 (2) INFORMATION FOR SEQ ID NO:1003: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 50 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: Genomic DNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1003: BTTTGCTCTC CTBTTBCTTT CTGTGTCCBT TTTTTCBTTB BCCGBGCTGT 50 (2) INFORMATION FOR SEQ ID NO:1004: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1004: WO 00/09525 PCT/US99/17712 EPI-109 391 GCCTGTGTCT GTCCTCCT 18 (2) INFORMATION FOR SEQ ID NO:1005: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1005: GCTTCGTTCC TCTCGTTC 18 (2) INFORMATION FOR SEQ ID NO:1006: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1006: CTGCTTGGTG CCCTTGCCG 19 (2) INFORMATION FOR SEQ ID NO:1007: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1007: GTCCTGCTCC TCCGGGCTGT GG 22 (2) INFORMATION FOR SEQ ID NO:1008: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 36 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1008: GTCGTGGCCC TGGCTCCGGC TGGTGGGCTC CCCTGG 36 (2) INFORMATION FOR SEQ ID NO:1009: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1009: CCTTCGCTGG CTGGCGGCGT GC 22 (2) INFORMATION FOR SEQ ID NO:1010: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 24 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1010: GGGTCTTGCT CTGGGCCTGG CTGT 24 (2) INFORMATION FOR SEQ ID NO:1011: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 20 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1011: GGCCGTGGTT GGGGGTCTTC 20 (2) INFORMATION FOR SEQ ID NO:1012: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 20 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1012: GCTGCCTCCG TTTGGGTGGC 20 (2) INFORMATION FOR SEQ ID NO:1013: WO 00/09525 PCT/US99/17712 EPI-109 392 (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 50 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1013: TCTCTGAATA TTGACCTTCC TCCATGGCGG TCCTGCTTGG ATTCTCCCGA 50 (2) INFORMATION FOR SEQ ID NO:1014: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 50 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: Genomic DNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1014: TCTCTGBBTB TTGBCCTTCC TCCBTGGCGG TCCTGCTTGG BTTCTCCCGB 50 (2) INFORMATION FOR SEQ ID NO:1015: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 39 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1015: GCCTTTCCTG GTTCTCTTGT TGTTTTTGGG GTTTGGCTT 39 (2) INFORMATION FOR SEQ ID NO:1016: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 50 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1016: ACAGTAGAGT AGGGGATTCC ATGGCAGGAG CCATCTTCTT CATGGACTCC 50 (2) INFORMATION FOR SEQ ID NO:1017: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 50 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1017: TTCAAGGAGA CCTTAGGTTT CTGAGGGACT GCTAACACGC CATCTGGAGC 50 (2) INFORMATION FOR SEQ ID NO:1018: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 77 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear. (ii) MOLECULE TYPE: Genomic DNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1018: BCBGTBGBGT BGGGGBTTCC BTGGCBGGBG CCBTCTTCTT CBTGGBCTCC TTCBBGGBGB 60 CCTTBGGTTT CTGBGGG 77 (2) INFORMATION FOR SEQ ID NO:1019: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 23 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: Genomic DNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1019: BCTGCTBBCB CGCCBTCTGG BGC 23 (2) INFORMATION FOR SEQ ID NO:1020: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 21 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1020: GTTGTTTTTG GGGTTTGGCT T 21 WO 00/09525 PCT/US99/17712 EPI-109 393 (2) INFORMATION FOR SEQ ID NO:1021: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1021: GCCTTTCCTG GTTCTCTT 18 (2) INFORMATION FOR SEQ ID NO:1022: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 50 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: Genomic DNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1022: BCBGTBGBGT BGGGGBTTCC BTGGCBGGBG CCBTCTTCTT CBTGGBCTCC 50 (2) INFORMATION FOR SEQ ID NO:1023: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 50 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: Genomic DNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1023: TTCBBGGBGB CCTTBGGTTT CTGBGGGBCT GCTBBCBCGC CBTCTGGBGC 50 (2) INFORMATION FOR SEQ ID NO:1024: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1024: GCCTGTGTCT GTCCTCCT 18 (2) INFORMATION FOR SEQ ID NO:1025: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1025: GCTTCGTTCC TCTCGTTC 18 (2) INFORMATION FOR SEQ ID NO:1026: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1026: CTGCTTGGTG CCCTTGCCG 19 (2) INFORMATION FOR SEQ ID NO:1027: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1027: GTCCTGCTCC TCCGGGCTGT GG 22 (2) INFORMATION FOR SEQ ID NO:1028: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 36 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1028: GTCCTCGCCC TGGCTCCGGC TGGTGGGCTC CCCTGG 36 (2) INFORMATION FOR SEQ ID NO:1029: WO 00/09525 PCT/US99/17712 EPI-109 394 (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1029: CCTTCGCTGG CTGGCGGCGT GC 22 (2) INFORMATION FOR SEQ ID NO:1030: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 24 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: Genomic DNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1030: CCCBGBBCGB GBCCCGGBCC GBCB 24 (2) INFORMATION FOR SEQ ID NO:1031: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 20 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1031: GGCCGTGGTT GGGGGTCTTC 20 (2) INFORMATION FOR SEQ ID NO:1032: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 20 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1032: GCTGCCTCCG TTTGGGTGGC 20 (2) INFORMATION FOR SEQ ID NO:1033: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 40 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: Genomic DNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1033: GBTCTCTGBB TBTTGBCCTT CCBTGGCGGT CCTGCTTGGB 40 (2) INFORMATION FOR SEQ ID NO:1034: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 26 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1034: TCTCCCTTGG GCTCTGGCTC CTTCTC 26 (2) INFORMATION FOR SEQ ID NO:1035: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 21 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1035: TCTCTCTCCC TCTCTCTCTG T 21 (2) INFORMATION FOR SEQ ID NO:1036: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 32 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1036: CGCCTCCGCC CTGGCTGCTG GGGTGGTGGT GC 32 (2) INFORMATION FOR SEQ ID NO:1037: (i) SEQUENCE CHARACTERISTICS: WO 00/09525 PCT/US99/17712 EPI-109 395 (A) LENGTH: 20 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1037: TTTTGTTCTT CCTTGCTGCC 20 (2) INFORMATION FOR SEQ ID NO:1038: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1038: GCCCCGCTGC TTGTCTTCCT CG 22 (2) INFORMATION FOR SEQ ID NO:1039: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 50 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: Genomic DNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1039: CTCTGTCCCT CTCTCTCTGT BCTCCTCBGG CTCCBTCBTC TCCCTTGGGC 50 (2) INFORMATION FOR SEQ ID NO:1040: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 21 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1040: CTTGCTCCTG GGGGCCTCCT G 21 (2) INFORMATION FOR SEQ ID NO:1041: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 21 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1041: GTCCCTCCGG GTGTTCCCGG C 21 (2) INFORMATION FOR SEQ ID NO:1042: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 81 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: Genomic DNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1042: GGGCCTGGCC TGGGGCBGGG GCCGCGTBGG CGCGGCTCGC CBGGBCGGGC BGCGCCBGCB 60 GCBGCBGBTT CBGCBTCCTG G 81 (2) INFORMATION FOR SEQ ID NO:1043: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 21 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1043: CTTGCTCCTG GGGGCCTCCT G 21 (2) INFORMATION FOR SEQ ID NO:1044: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 21 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1044: GTCCCTCTGG CTGTTCCCGG C 21 (2) INFORMATION FOR SEQ ID NO:1045: (i) SEQUENCE CHARACTERISTICS: WO 00/09525 PCTIUS99/17712 EPI-109 396 (A) LENGTH: 90 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: Genomic DNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1045: CCTGGBCTGG GGCBGGGGCC GCGTBGGCGC GGCTCGCCBG GBCGGGCBGC GCCBGCBGCB 60 GCBGGCTCBG CBTCCTGGCC BCGGBBTTCC 90 (2) INFORMATION FOR SEQ ID NO:1046: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 20 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1046: GGTGTGCGGG GCCTGGTGCC 20 (2) INFORMATION FOR SEQ ID NO:1047: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 23 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1047: CCTGGGCCTC GGGTGCTGCC TGT 23 (2) INFORMATION FOR SEQ ID NO:1048: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 20 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1048: GCGCTGCCTT CTTCTCCTGG 20 (2) INFORMATION FOR SEQ ID NO:1049: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 32 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1049: GTCCTCGCCG GGGCCCTTGC TGCCCTGGCT GT 32 (2) INFORMATION FOR SEQ ID NO:1050: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 25 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1050: GCCCTGGGGG TCTGGGTTCG GCTGT 25 (2) INFORMATION FOR SEQ ID NO:1051: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 60 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: Genomic DNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1051: CCCCBGCBGG BCCBGTCCCB TCCBCBGCGT GTGBTGBGTB GCCBTTCTCC TGCBGCCGBG 60 (2) INFORMATION FOR SEQ ID NO:1052: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: Genomic DNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1052: GGGCGCGGGC GBGCBTCGC 19 (2) INFORMATION FOR SEQ ID NO:1053: WO 00/09525 PCT/US99/17712 EPI-109 397 (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1053: TTTGGGCTTT TCTCCTTTGG TT 22 (2) INFORMATION FOR SEQ ID NO:1054: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 60 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: Genomic DNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1054: TGBGCGCCBG GBCCGCGCBC BGCBGCBGGG CGCGGGCGBG CBTCGCBGCG GCGGGCBGGG 60 (2) INFORMATION FOR SEQ ID NO:1055: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 20 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1055: GCCCTGCTGC TCTTTCTGCT 20 (2) INFORMATION FOR SEQ ID NO:1056: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1056: TCCCTTGGTG GGTTGGGCC 19 (2) INFORMATION FOR SEQ ID NO:1057: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1057: TTGCTGCCCC TTCTGTCCC 19 (2) INFORMATION FOR SEQ ID NO:1058: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1058: TTGCTGCCCC TTCTGTCCC 19 (2) INFORMATION FOR SEQ ID NO:1059: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1059: TGTTTGCTGG TGTCTGCGC 19 (2) INFORMATION FOR SEQ ID NO:1060: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 60 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: Genomic DNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1060: CCCCBBCBGB BGBBGCBGBC BBBTTTGGGB BGTGBBCBGT TTTGGBBCCB TGTTTCCTGT 60 (2) INFORMATION FOR SEQ ID NO:1061: (i) SEQUENCE CHARACTERISTICS: WO 00/09525 PCTIUS99/17712 EPI-109 398 (A) LENGTH: 19 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1061: GCGCTCGGCC TGGTCCCGG 19 (2) INFORMATION FOR SEQ ID NO:1062: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 20 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1062: GGGTCTCCTC TTGTTGTTGC 20 (2) INFORMATION FOR SEQ ID NO:1063: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1063: TTGCGCCTCC TGCTGGGGGT CC 22 (2) INFORMATION FOR SEQ ID NO:1064: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 21 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1064: CTCTGTTCTT GTTTTGGGGG C 21 (2) INFORMATION FOR SEQ ID NO:1065: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1065: GGGCCCGGCC GTTGTCTTG 19 (2) INFORMATION FOR SEQ ID NO:1066: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1066: GTTTGGGGGT TTCCGTTG 18 (2) INFORMATION FOR SEQ ID NO:1067: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 26 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1067: GGGTTCTCCT GGCCCGGGCC TTGCCC 26 (2) INFORMATION FOR SEQ ID NO:1068: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 23 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1068: GGCCGTGGTC CCGGCTTCGT TGC 23 (2) INFORMATION FOR SEQ ID NO:1069: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 24 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single WO 00/09525 PCT/US99/17712 EPI-109 399 (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1069: CCTGTCTCCG TCTCGGCTCT TCTG 24 (2) INFORMATION FOR SEQ ID NO:1070: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1070: GGGCCTTGCG CTGTCTTTGG TG 22 (2) INFORMATION FOR SEQ ID NO:1071: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 60 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: Genomic DNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1071: GCBCCGTCCB GTGBTGGTGC GGTBCTTGTC GCTGCBGCGC TCGGCCTGGT CCCGGBGBGC 60 (2) INFORMATION FOR SEQ ID NO:1072: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1072: GCGCGGGCCG GGGGCTGCTG GG 22 (2) INFORMATION FOR SEQ ID NO:1073: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1073: GGTTGGCCCG GGGTGCCCC 19 (2) INFORMATION FOR SEQ ID NO:1074: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 29 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1074: GCCGCTGGGT GCCCTCGTCC TCTGCGGTC 29 (2) INFORMATION FOR SEQ ID NO:1075: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 23 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1075: GTGTCTCCTG GCTCTGGTTC CCC 23 (2) INFORMATION FOR SEQ ID NO:1076: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 31 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1076: GCTGCGCCCG TTGTCCTCTG GGGTGGCCTT C 31 (2) INFORMATION FOR SEQ ID NO:1077: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 23 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1077: WO 00/09525 PCT/US99/17712 EPI-109 400 GCTCCCGGGT CTGGTTCTTG TGT 23 (2) INFORMATION FOR SEQ ID NO:1078: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 26 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1078: TGGGGGTCCC TTTTTGGGCC TGTTGT 26 (2) INFORMATION FOR SEQ ID NO:1079: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 24 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1079: GGCGTGGCTT GTGTGTTCGG TTTC 24 (2) INFORMATION FOR SEQ ID NO:1080: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 21 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1080: TGCCCTGTCC TCCGGCGTCC C 21 (2) INFORMATION FOR SEQ ID NO:1081: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 142 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: Genomic DNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1081: CGGBGCCTCC CCGGGGCBGG BTGBCTTTTG BGGGGGBCBC BGBTGTCTGG GCBTTGCCBG 60 GTCCTGGGBB CBGBGCCCCG BGCBGGBCCB GGBGTGCGGG CBGCGCGGGC CGGGGGCTGC 120 TGGGBGCCBT BGCGBGGCTG BG 142 (2) INFORMATION FOR SEQ ID NO:1082: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1082: CCTCTTTTCT GTTTTTCCC 19 (2) INFORMATION FOR SEQ ID NO:1083: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 21 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1083: CTCTGCCTTT GTTTGGGTTC G 21 (2) INFORMATION FOR SEQ ID NO:1084: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1084: CTTCCTTTCT GCTTCTTCC 19 (2) INFORMATION FOR SEQ ID NO:1085: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 29 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1085: WO 00/09525 PCT/US99/17712 EPI-109 401 CTGTGTCTCC TGTCTCCGCT TTTTTCTTC 29 (2) INFORMATION FOR SEQ ID NO:1086: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 24 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1086: GTCTTTGTTG TTTTCTCTTC CTTG 24 (2) INFORMATION FOR SEQ ID NO:1087: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 130 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: Genomic DNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1087: CTGBGCBBGB TBTCTBGBTT CTGGGGTGGT CTCGBTTTTB BBBGCTTGBG BBGCTGCBBB 60 CBTTBTCCBB BGTBTBTTTG BGGCTCCBBG GBTCBCGBCC BTCTTCCCBG GCBTTTTBBG 120 TTGCTGTCGT 130 (2) INFORMATION FOR SEQ ID NO:1088: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1088: GTTCTTGGCT TCTTCTGTC 19 (2) INFORMATION FOR SEQ ID NO:1089: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 20 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1089: CGTTGGCTTC TCGTTGTCCC 20 (2) INFORMATION FOR SEQ ID NO:1090: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 20 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1090: TGTGGGCTTC TCGTTGTCCC 20 (2) INFORMATION FOR SEQ ID NO:1091: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1091: CCCTTCGGGG GCTGGTGG 18 (2) INFORMATION FOR SEQ ID NO:1092: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 9 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single .(D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1092: GGCTGGTGG 9 (2) INFORMATION FOR SEQ ID NO:1093: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1093: WO 00/09525 PCT/US99/17712 EPI-109 402 GGCCGTCCTT GCCTGCTGG 19 (2) INFORMATION FOR SEQ ID NO:1094: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 41 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1094: TTTTCTCTTT CGCTTTCTTT TCGTCTCCTG TTCCTCCTTT T 41 (2) INFORMATION FOR SEQ ID NO:1095: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 36 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1095: TTGCTGTTTT TTCTCCTTCT TCTCTCCTTT CTTTTC 36 (2) INFORMATION FOR SEQ ID NO:1096: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 41 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1096: TTTTCTCTTT CGCTTTCTTT TCGTCTCCTG TTCCTCCTTT T 41 (2) INFORMATION FOR SEQ ID NO:1097: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 36 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1097: TTGCTGTTTT TTCTCCTTCT TCTCTCCTTT CTTTTC 36 (2) INFORMATION FOR SEQ ID NO:1098: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 33 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1098: CTCTGTCTTG TTCTGGTCCT TCGTGGGGCT CTG 33 (2) INFORMATION FOR SEQ ID NO:1099: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 24 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1099: TGTCGCGTGG GTGCGGCCGT GGCC 24 (2) INFORMATION FOR SEQ ID NO:1100: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 69 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: Genomic DNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1100: GGCGGBCCBG GBGTTGGBGC BGGBGCBGGB CGGGCBGGCG GCTCBTGTTT GGBTCGGCBG 60 GBGGCBCTC 69 (2) INFORMATION FOR SEQ ID NO:1101: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:ll01: TCTGGGGTGT CCTG 14 WO 00/09525 PCTIUS99/17712 EPI-109 403 (2) INFORMATION FOR SEQ ID NO:1102: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1102: GCCTTCGTGG TTCC 14 (2) INFORMATION FOR SEQ ID NO:1103: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1103: TCTTCCTTCG TTTGC 15 (2) INFORMATION FOR SEQ ID NO:1104: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1104: GGCTGCGCTC CTGCCCCGC 19 (2) INFORMATION FOR SEQ ID NO:1105: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1105: GGCTGCGCTC CTGCCCCGC 19 (2) INFORMATION FOR SEQ ID NO:1106: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 17 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1106: CTCTTTCCCG GGCTCTT 17 (2) INFORMATION FOR SEQ ID NO:1107: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 17 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1107: GCGCTGGGGG GTGCTCC 17 (2) INFORMATION FOR SEQ ID NO:1108: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 28 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1108: CGTGTGTTTG CGCCCTCCTC CTGGTCGC 28 (2) INFORMATION FOR SEQ ID NO:1109: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1109: GCTTGTCGTT TTGG 14 (2) INFORMATION FOR SEQ ID NO:ll10: WO 00/09525 PCT/US99/17712 EPI-109 404 (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 21 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:ll10: GGCCGGCTTT GCCCGCCTCC C 21 (2) INFORMATION FOR SEQ ID NO:llll: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 16 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:llll: GGCGCCTGGC CCGGCC 16 (2) INFORMATION FOR SEQ ID NO:1112: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1112: TTCCTGGGCT GCGTGCGC 18 (2) INFORMATION FOR SEQ ID NO:1113: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 20 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:lll3: GTTCTGTTCT TCTTCCTGGC 20 (2) INFORMATION FOR SEQ ID NO:1114: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 78 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: Genomic DNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1114: GCBGGBGBCB GGGCBGGGCG BTCBGGBGCB GCGTGBGCCB BBGGBGGBCC BTCGGGBBCG 60 CBGCTCCGGB BCGCBGGB 78 (2) INFORMATION FOR SEQ ID NO:1115: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1115: CTCTGGTTGG CTTCCTTC 18 (2) INFORMATION FOR SEQ ID NO:1116: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 70 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: Genomic DNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1116: GCCGGCBCBT GCTBGCBGGB BGBBCBGBGG GGGBBGCBGT TGGGBGGTGB GBCCCBTTBB 60 TBGGTGTCGB 70 (2) INFORMATION FOR SEQ ID NO:1117: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1117: TCTGCGCGCC CCTGCTCC 18 WO 00/09525 PCT/US99/17712.. EPI-109 405 (2) INFORMATION FOR SEQ ID NO:1118: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1118: CGCCCGGCTT CTCT 14 (2) INFORMATION FOR SEQ ID NO:1119: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1119: CGTGTGGGCT TCGG 14 (2) INFORMATION FOR SEQ ID NO:1120: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 21 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1120: CCCCGCGCCT CCGTTGTTCT C 21 (2) INFORMATION FOR SEQ ID NO:1121: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1121: TGCTCGCTGG GCTTG 15 (2) INFORMATION FOR SEQ ID NO:1122: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 23 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1122: GGTTTCCTGG GGCCCTGGGT TTC 23 (2) INFORMATION FOR SEQ ID NO:1123: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 17 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1123: TCTGCCGGGT CGTTTTC 17 (2) INFORMATION FOR SEQ ID NO:1124: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1124: GGGTGCTGGC TGCG 14 (2) INFORMATION FOR SEQ ID NO:1125: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 17 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1125: CTTGGTGCTG GGGCTCC 17 (2) INFORMATION FOR SEQ ID NO:1126: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 base pairs WO 00/09525 PCT/US99/17712 EPI-109 406 (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1l26: GGCGGCTGCG GGCTGGGTTG GG 22 (2) INFORMATION FOR SEQ ID NO:1127: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 23 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1127: CTTGGCTGGT TCCTGGCCTC GGG 23 (2) INFORMATION FOR SEQ ID NO:1128: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 35 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1128: CCTCCTCCTC CTCCTCGCTC CCTTTTTCTT CCTCT 35 (2) INFORMATION FOR SEQ ID NO:1129: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1129: TCCCTGCTGC TCTC 14 (2) INFORMATION FOR SEQ ID NO:1130: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 20 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1130: TGCCCTCCCT TCCCTCCTGG 20 (2) INFORMATION FOR SEQ ID NO:1131: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 20 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1131: GGTGCCTCCT TGGGCCCTGC 20 (2) INFORMATION FOR SEQ ID NO:1l32: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 16 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1132: GGCTGCTCCT TGCCCC 16 (2) INFORMATION FOR SEQ ID NO:1l33: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 17 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1133: CTCTGGGTCG GGCTGGC 17 (2) INFORMATION FOR SEQ ID NO:1134: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear WO 00/09525 PCTIUS99/17712 EPI-109 407 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:ll34: GGGGCGTCTC TGTGC 15 (2) INFORMATION FOR SEQ ID NO:1135: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1135: CTGGCCTGGG TGCC 14 (2) INFORMATION FOR SEQ ID NO:l136: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 29 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1136: GCCTCTCCTG GGGGGGTGGC TCCCTGTCC 29 (2) INFORMATION FOR SEQ ID NO:1137: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 17 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1137: CCTTTTCCCC CGGCTCC 17 (2) INFORMATION FOR SEQ ID NO:1138: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1138: GTGGGGGCTT TGGC 14 (2) INFORMATION FOR SEQ ID NO:1139: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 25 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1139: GGGGGTCTGT GGCCTGCTCC TGGGG 25 (2) INFORMATION FOR SEQ ID NO:1140: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 17 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1140: AGGGGTCTGG GGCCCTC 17 (2) INFORMATION FOR SEQ ID NO:1141: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear ' (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1141: TTTTGGGGGT CTGGCTTG 18 (2) INFORMATION FOR SEQ ID NO:1142: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1142: GCCTGGCTGC CTTCC 15 WO 00/09525 PCT/US99/17712 EPI-109 408 (2) INFORMATION FOR SEQ ID NO:1143: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 17 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1143: GGGGCCTGCC GTGGGGC 17 (2) INFORMATION FOR SEQ ID NO:1144: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 20 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear ~ (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1144: TGTCCTCTGT TGCTCCCCTT 20 (2) INFORMATION FOR SEQ ID NO:1145: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1145: TGCCTGCTGT CTGG 14 (2) INFORMATION FOR SEQ ID NO:1146: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 16 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1146: GGTTCCCGCC TTCCCT 16 (2) INFORMATION FOR SEQ ID NO:1147: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 100 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1147: GTTCCCAGAG CTTGCCACCT GCAGCAGGAC CAGGCAGCTC ACAGGGAACA GGAGCCCAGA 60 GCAAAGCCAC CCCATTGGGA GATGCCAAGG CACCAGGCTG 100 (2) INFORMATION FOR SEQ ID NO:1148: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 100 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: Genomic DNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1148: GTTCCCBGBG CTTGCCBCCT GCBGCBGGBC CBGGCBGCTC BCBGGGBBCB GGBGCCCBGB 60 GCBBBGCCBC CCCBTTGGGB GBTGCCBBGG CBCCBGGCTG 100 (2) INFORMATION FOR SEQ ID NO:1149: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1149: TCCCTGTTTC CCCCCTTT 18 (2) INFORMATION FOR SEQ ID NO:1150: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 21 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1150: CGTTCTGCGT TTGCCTTTGG C 21 WO 00/09525 PCT/US99/17712 EPI-109 409 (2) INFORMATION FOR SEQ ID NO:1151: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1151: GTTTTTTGTT TGTTTTCT 18 (2) INFORMATION FOR SEQ ID NO:1152: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1152: CTCTCCGTCT TTCTTCTCC 19 (2) INFORMATION FOR SEQ ID NO:1153: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 25 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1153: CCTCCTGCCT GTGTCCCTGC TCCCC 25 (2) INFORMATION FOR SEQ ID NO:1154: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1154: GAGGGTTTCT GGCTTCCTCT CT 22 (2) INFORMATION FOR SEQ ID NO:1155: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 20 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1155: TGTCTCTCTG TCCTTTTGTT 20 (2) INFORMATION FOR SEQ ID NO:1156: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 32 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1156: TGTTGTGCGG CCTGGTGCTG CCCTGCCCCG GG 32 (2) INFORMATION FOR SEQ ID NO:1157: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 89 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: Genomic DNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1157: GTGGGBBTTT CTGTGGGGBT GGCBTBCBCG TBGGCBGCTC CBBGBGCTBG CBBBCTCBBB 60 TGCBGBBGCB TCCTCBTGGC TCTGBBBCG 89 (2) INFORMATION FOR SEQ ID NO:1158: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1158: GTGTGTCTTT GCTGT 15 (2) INFORMATION FOR SEQ ID NO:1159: WO 00/09525 PCTIUS99/17712 EPI-109 410 (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1159: TTCCTTTGCT CTTG 14 (2) INFORMATION FOR SEQ ID NO:1160: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1160: GTGTGTCTTT GCTGT 15 (2) INFORMATION FOR SEQ ID NO:1161: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1161: GCCCTGCCTC TCTGC 15 (2) INFORMATION FOR SEQ ID NO:1162: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 17 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1162: GGGGGTGGCT TCCTGCC 17 (2) INFORMATION FOR SEQ ID NO:1163: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1163: GCGTCTCTGG GCCGTCCC 18 (2) INFORMATION FOR SEQ ID NO:1164: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 36 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1164: GTCCCTCGGC CCCGCGCCGC GCTCGGCTCC TCTCCC 36 (2) INFORMATION FOR SEQ ID NO:1165: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 13 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1165: TCTGGCCCGG CTC 13 (2) INFORMATION FOR SEQ ID NO:1166: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 26 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1166: GGGGCGGGGC GGGGCGGTGG GCGGGC 26 (2) INFORMATION FOR SEQ ID NO:1167: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid WO 00/09525 PCT/US99/17712 EPI-109 411 (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1167: GGCGCTGCCC TGCGC 15 (2) INFORMATION FOR SEQ ID NO:1168: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1168: TGCTGGCCGT CGGCTGCGCG CTGCTGGCTG CCCT 34 (2) INFORMATION FOR SEQ ID NO:1169: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 34 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1169: TGCTGGCCGT CGGCTGCGCG CTGCTGGCTG CCCT 34 (2) INFORMATION FOR SEQ ID NO:1170: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1170: GCTGGCCGCG CCGGG 15 (2) INFORMATION FOR SEQ ID NO:1171: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1171: GCCTGTCCGC CTCTGCGGG 19 (2) INFORMATION FOR SEQ ID NO:1172: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1172: CGCTGTCTCC TGGC 14 (2) INFORMATION FOR SEQ ID NO:1173: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1173: TTGTCTTCCG GCTCT 15 (2) INFORMATION FOR SEQ ID NO:1174: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single .(D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1174: TCTGCTGGGG TGGG 14 (2) INFORMATION FOR SEQ ID NO:1175: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1175: WO 00/09525 PCT/US99/17712 EPI-109 412 GCTGGGCGGC CGGCCCGGT 19 (2) INFORMATION FOR SEQ ID NO:1176: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1176: GCTGGGGCTC CTCGGGGGG 19 (2) INFORMATION FOR SEQ ID NO:1177: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1177: GGGGGCTCTT CCGG 14 (2) INFORMATION FOR SEQ ID NO:1178: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 16 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1178: GCTGTCTCCC TCCGGG 16 (2) INFORMATION FOR SEQ ID NO:1179: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 16 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1179: GCGGGGGTTT CTGGCC 16 (2) INFORMATION FOR SEQ ID NO:1180: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1180: GTGGGGGTCT TGCC 14 (2) INFORMATION FOR SEQ ID NO:1181: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:ll81: TGGCCTCCGG GCTCC 15 (2) INFORMATION FOR SEQ ID NO:1182: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 20 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1182: TGCTTGTCTT GCCTTCCTTC 20 (2) INFORMATION FOR SEQ ID NO:1183: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1183: TCTGGTCGGT TGTGGCTCG 19 (2) INFORMATION FOR SEQ ID NO:1184: WO 00/09525 PCT/US99/17712 EPI-109 413 (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 20 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1184: GGGCTCCGTG GGTCCCTGGC 20 (2) INFORMATION FOR SEQ ID NO:1185: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1185: GCCCGTTTGT GTTTTGTC 18 (2) INFORMATION FOR SEQ ID NO:1186: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1l86: TTTTCCCCTG GCGT 14 (2) INFORMATION FOR SEQ ID NO:1187: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 35 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1187: CCCTGTGCCC CTCTCCTCTC CTTCCTCTGC TTCTC 35 (2) INFORMATION FOR SEQ ID NO:1188: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1188: GCTCTCCTTT GTGGG 15 (2) INFORMATION FOR SEQ ID NO:1189: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1189: GCCCTCCCTG CTGCT 15 (2) INFORMATION FOR SEQ ID NO:1190: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1190: CTTGGTTTTG GGCT 14 (2) INFORMATION FOR SEQ ID NO:1191: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1191: TTTTTTCTCT TCCTCCTTTT TC 22 (2) INFORMATION FOR SEQ ID NO:1192: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid WO 00/09525 PCTIUS99/17712 EPI-109 414 (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1192: GTGCGTGGGC CTCC 14 (2) INFORMATION FOP SEQ ID NO:1193: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 8 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1193: CCCGGCGC 8 (2) INFORMATION FOR SEQ ID NO:1194: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 150 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1194: GCACGCCTCT TGCCACCTCC TGCGCAGGGC AGCGCCTTGG GGCCAGCGCC GCTCCCGGCG 60 CGGCCAGCAG GGCAGCCAGC AGCGCGCAGC CGACGGCCAG CATGCTTCCT CCTCGGCTAC 120 CACTCCATGG TCCCGCAGAG GCGGACAGGC 150 (2) INFORMATION FOR SEQ ID NO:1195: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 10 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: Genomic DNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1195: GGCCBGCBGG 10 (2) INFORMATION FOR SEQ ID NO:1196: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 150 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: Genomic DNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1196: GCBCGCCTCT TGCCBCCTCC TGCGCBGGGC BGCGCCTTGG GGCCBGCGCC GCTCCCGGCG 60 CGGCCBGCBG GGCBGCCBGC BGCGCGCBGC CGBCGGCCBG CBTGCTTCCT CCTCGGCTBC 120 CBCTCCBTGG TCCCGCBGBG GCGGBCBGGC 150 (2) INFORMATION FOR SEQ ID NO:1197: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 27 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1197: GCTTCTCTTT CGTTCCCGGT GGGCTCG 27 (2) INFORMATION FOR SEQ ID NO:1198: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 23 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1198: GTGGCTGTCT GTGTGGGGCG GCT 23 (2) INFORMATION FOR SEQ ID NO:1199: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1199: GTGCCTCTTT GCTGCTTTC 19 WO 00/09525 PCT/US99/17712 EPI-109 415 (2) INFORMATION FOR SEQ ID NO:1200: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 20 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1200: GATTCTTTGC CTTTTTCTGC 20 (2) INFORMATION FOR SEQ ID NO:1201: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1201: GCTTGTGTGC TCTGCTGTCT CT 22 (2) INFORMATION FOR SEQ ID NO:1202: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 37 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1202: TGGTTCCTTC CGGTGGTTTC TTCCTGGCTC TTGTCCT 37 (2) INFORMATION FOR SEQ ID NO:1203: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 17 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1203: TTCTCTTGGC CCTTGGC 17 (2) INFORMATION FOR SEQ ID NO:1204: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 39 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1204: TGGTGGGGCT GGGGCTCCGG GGTCTCTGCC CCTCCGTGC 39 (2) INFORMATION FOR SEQ ID NO:1205: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 28 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1205: CGCGTGGGGC CGCGCTCGCC GGCCCCCC 28 (2) INFORMATION FOR SEQ ID NO:1206: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 24 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1206: CCTGCCGGGT GGGCTCCCGC CGCG 24 (2) INFORMATION FOR SEQ ID NO:1207: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 20 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1207: CGCCGGCCTG CCGGCCCCTC 20 (2) INFORMATION FOR SEQ ID NO:1208: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 39 base pairs WO 00/09525 PCT/US99/17712 EPI-109 416 (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1208: GTGGGTCCTG CTGGCCGGGT CCGGGTCCCG GGGGTGGGG 39 (2) INFORMATION FOR SEQ ID NO:1209: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: Genomic DNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1209: CGCGBGTCGG CGGCCGBGGG TC 22 (2) INFORMATION FOR SEQ ID NO:1210: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: Genomic DNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1210: GGCCTCCBCC BGGGBCBTG 19 (2) INFORMATION FOR SEQ ID NO:1211: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1211: GTCCTTCTTG TCCGCTGCC 19 (2) INFORMATION FOR SEQ ID NO:1212: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 25 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1212: TCTCTGGGGT TTTCGGTCTG GGTGG 25 (2) INFORMATION FOR SEQ ID NO:1213: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 24 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1213: GCTTTCCTCC TGGGGCTGCT GCTG 24 (2) INFORMATION FOR SEQ ID NO:1214: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 28 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1214: GGCTCTTCTT TTTGTTTCTG GCCTGGTG 28 (2) INFORMATION FOR SEQ ID NO:1215: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1215: CTCTCTCGTG CCCTTTCC 18 (2) INFORMATION FOR SEQ ID NO:1216: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 20 base pairs (B) TYPE: nucleic acid WO 00/09525 PCTIUS99/17712 EPI-109 417 (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1216: CTTGGGTGTC TTGTTTTTGT 20 (2) INFORMATION FOR SEQ ID NO:1217: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: Genomic DNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1217: GGCCTCCBCC BGGGBCBTG 19 (2) INFORMATION FOR SEQ ID NO:1218: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 25 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1218: GTGGGGCCTG CTCTCCCGGC CTCCG 25 (2) INFORMATION FOR SEQ ID NO:1219: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 29 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1219: TGTGTTGCTG GGTGTTTTCC CGTCTCTGG 29 (2) INFORMATION FOR SEQ ID NO:1220: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1220: TCTGCCTTCG GGGGTCGT 18 (2) INFORMATION FOR SEQ ID NO:1221: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: Genomic DNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1221: GGGTCCTCBT GGCTGGGG 18 (2) INFORMATION FOR SEQ ID NO:1222: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: Genomic DNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1222: GCCTGGGCCT GCBGGGCC 18 (2) INFORMATION FOR SEQ ID NO:1223: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 20 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: Genomic DNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1223: GCTCTTGCCT GGBGTGGCTC 20 (2) INFORMATION FOR SEQ ID NO:1224: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 base pairs WO 00/09525 PCT/US99/17712 EPI-109 418 (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: Genomic DNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1224: GCCCBGBGTC TTCCCTGGT 19 (2) INFORMATION FOR SEQ ID NO:1225: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 20 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear. (ii) MOLECULE TYPE: Genomic DNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1225: GGGTCCTCBT GGCTGGGGTC 20 (2) INFORMATION FOR SEQ ID NO:1226: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1226: CCTCTCTCCC GTCCT 15 (2) INFORMATION FOR SEQ ID NO:1227: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 23 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1227: GTCTTTGTTT CTGGGCTCGT GCC 23 (2) INFORMATION FOR SEQ ID NO:1228: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 24 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear. (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1228: CCBTCCCGGC TTCTCTCTGG TTCC 24 (2) INFORMATION FOR SEQ ID NO:1229: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1229: GTCCTCTGTG GTGTTTGG 18 (2) INFORMATION FOR SEQ ID NO:1230: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 21 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1230: CCCTGCTTCC TTTTGCCTGT T 21 (2) INFORMATION FOR SEQ ID NO:1231: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 85 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1231: GAGGGGGCAG CAGTTGGGCC CCAAAGGCCC TCTCGTTCAC CTTCTGGCAC GGAGTTGCAT 60 CCCCATAGTC AAACTCTGTG GTCGT 85 (2) INFORMATION FOR SEQ ID NO:1232: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 59 base pairs WO 00/09525 PCT/US99/17712 EPI-109 419 (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1232: GTCATAGTCC TCTGTGGTGT TTGGAGTTTC CATCCCGGCT TCTCTCTGGT TCCAAGGGA 59 (2) INFORMATION FOR SEQ ID NO:1233: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 86 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: Genomic DNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1233: GBGGGGGCBG CBGTTGGGCC CCBBBGGCCC TCTCGTTCBC CTTCTGGCBC GGBGTTGCBT 60 CCCCBTBGTC BBBCTCTGTG GTCGTG 86 (2) INFORMATION FOR SEQ ID NO:1234: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 58 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: Genomic DNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1234: TCBTBGTCCT CTGTGGTGTT TGGBGTTTCC BTCCCGGCTT CTCTCTGGTT CCBBGGGB 58 (2) INFORMATION FOR SEQ ID NO:1235: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 84 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: Genomic DNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1235: GGGCBCGGGG CBGTGGGCGG GCBBTGTBGG CBBBGCBGCB GGGTGTGGTG TCCGBGGBBT 60 BTGGGGBGGC BGBTGCBGGB GCGC 84 (2) INFORMATION FOR SEQ ID NO:1236: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 78 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: Genomic DNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1236: BGBGGGCBGT BGCBBTGBGG BTGBCBGCGB GGCGTGCCGC GGBGBCCTTC BTGGTBCCTG 60 TGGBGBGGCT GTCGGBGG 78 (2) INFORMATION FOR SEQ ID NO:1237: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 70 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1237: GGGTGTGGTG TCCGCTTGGC GGTTCTTTCG GGTGTTTCTT CTCTGGGTTG GCCTGCTGCT 60 CGTCGTGGTC 70 (2) INFORMATION FOR SEQ ID NO:1238: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 71 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1238: GCTCCGCTCC CGGGTTCGTC TCGCTCTGTC GCCCCTTCCT TCCTTGTCGT GTTCCTCCCT 60 TCCTTGCCTC T 71 (2) INFORMATION FOR SEQ ID NO:1239: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear WO 00/09525 PCT/US99/17712 EPI-109 420 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1239: GGGTGTGGTG TCCG 14 (2) INFORMATION FOR SEQ ID NO:1240: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 20 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1240: CTTGGCGGTT CTTTCGGGTG 20 (2) INFORMATION FOR SEQ ID NO:1241: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1241: TTTCTTCTCT GGGTTGGC 18 (2) INFORMATION FOR SEQ ID NO:1242: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1242: CTGCTGCTCG TCGTGGTC 18 (2) INFORMATION FOR SEQ ID NO:1243: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 17 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1243: GCTCCGCTCC CGGGTTC 17 (2) INFORMATION FOR SEQ ID NO:1244: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 17 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1244: GTCTCGCTCT GTCGCCC 17 (2) INFORMATION FOR SEQ ID NO:1245: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1245: CTTCCTTCCT TGTC 14 (2) INFORMATION FOR SEQ ID NO:1246: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 23 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1246: GTGTTCCTCC CTTCCTTGCC TCT 23 (2) INFORMATION FOR SEQ ID NO:1247: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: Genomic DNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1247: GTTCBTGGTG GCTBGGTGGG GC 22 WO 00/09525 PCT/US99/17712 EPI-109 421 (2) INFORMATION FOR SEQ ID NO:1248: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 26 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1248: GCTGCCCGGC GGGGTGTGCG CTTGGC 26 (2) INFORMATION FOR SEQ ID NO:1249: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 30 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1249: GCTCCCGTGC TCGGTTCTCT GTCTCCCGGT 30 (2) INFORMATION FOR SEQ ID NO:1250: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1250: CCCCCTTTGC CTGGCGTCTC GG 22 (2) INFORMATION FOR SEQ ID NO:1251: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH- 29 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1251: GCCTTCGTCC TCTTCCTCTT CTTCCTTCC 29 (2) INFORMATION FOR SEQ ID NO:1252: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 43 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1252: GCTCCGTGGG GGCTGCTTGG TGGGGGCCTG TGCCTCGGGG TCC 43 (2) INFORMATION FOR SEQ ID NO:1253: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 20 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1253: CGGGGCTTCT GGCCCTTGCC 20 (2) INFORMATION FOR SEQ ID NO:1254: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1254: GTTCATGGTG GCTAGGTGGG GC 22 (2) INFORMATION FOR SEQ ID NO:1255: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 24 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: Genomic DNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1255: GGGGTGGGTB GGCCGTGTCT GGGG 24 (2) INFORMATION FOR SEQ ID NO:1256: WO 00/09525 PCT/US99/17712 EPI-109 422 (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: Genomic DNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1256: GTTGGCCBTG TTGGTTGCC 19 (2) INFORMATION FOR SEQ ID NO:1257: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1257: TCTTGGTGGT GCGCCGGGC 19 (2) INFORMATION FOR SEQ ID NO:1258: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 47 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1258: GCGTCTTGGC TTTCTTCTCC TTCGGGCCCT CGGGCCGGTG CTTGTGG 47 (2) INFORMATION FOR SEQ ID NO:1259: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 38 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1259: GCTCCTCCCG GGCGGCCTCC CCGGGCGGGG GCTTCTTG 38 (2) INFORMATION FOR SEQ ID NO:1260: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 23 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1260: GCGCTGGCGG GGGGGCCTCC TCC 23 (2) INFORMATION FOR SEQ ID NO:1261: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 37 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1261: GCTCTGTGGC TGGGCGTTCC TTGGTGTTCT GGGTGGC 37 (2) INFORMATION FOR SEQ ID NO:1262: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 27 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1262: TGGCGGGCGT GGTGGCCTCT GTGGTGG 27 (2) INFORMATION FOR SEQ ID NO:1263: (i) SEQUENCE CHARACTERISTICS: *(A) LENGTH: 19 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: Genomic DNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1263: GGGCCCGCGG CTGCBGGGG 19 (2) INFORMATION FOR SEQ ID NO:1264: Ci) SEQUENCE
CHARACTERISTICS:
WO 00/09525 PCT/US99/17712 EPI-109 423 (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1264: TTGCCTGTCT GCTTCGTC 18 (2) INFORMATION FOR SEQ ID NO:1265: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 20 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1265: CTTTGCGCTC CCGGGCCGCC 20 (2) INFORMATION FOR SEQ ID NO:1266: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 24 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1266: GGGGTGGGTA GGCCGTGTCT GGGG 24 (2) INFORMATION FOR SEQ ID NO:1267: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1267: GTTGGCCATG TTGGTTGCC 19 (2) INFORMATION FOR SEQ ID NO:1268: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1268: GGGCCCGCGG CTGCAGGGG 19 (2) INFORMATION FOR SEQ ID NO:1269: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 17 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1269: CGGTTTCCTT TGCGGTC 17 (2) INFORMATION FOR SEQ ID NO:1270: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1270: TTGGCCCGGG CTCCGGGTG 19 (2) INFORMATION FOR SEQ ID NO:1271: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 23 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1271: CCCGCCCGCC CGCCGGCCGC CGC 23 (2) INFORMATION FOR SEQ ID NO:1272: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 27 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single WO 00/09525 PCT/U$99/17712 EPI-109 424 (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1272: CCCGCCGGGC TGTCCCCGCC CCGCCCC 27 (2) INFORMATION FOR SEQ ID NO:1273: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 17 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1273: GGCCCGGGGC GCGGGGG 17 (2) INFORMATION FOR SEQ ID NO:1274: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 20 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1274: CGGCCCTCCC GCCCCTCTGG 20 (2) INFORMATION FOR SEQ ID NO:1275: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 17 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1275: GCCGGCGCGG GCGTCGG 17 (2) INFORMATION FOR SEQ ID NO:1276: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 37 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1276: CCGCTCGCGC CTGGGGTTCC CTCTCCTCCC CCTGTGC 37 (2) INFORMATION FOR SEQ ID NO:1277: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1277: GCCTGCCTCT TGCTCTTC 18 (2) INFORMATION FOR SEQ ID NO:1278: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 20 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1278: TGCGTCCGCT GCCTTCTCCC 20 (2) INFORMATION FOR SEQ ID NO:1279: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 23 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1279: CTCTCCTCGG CCGTTGCCTG TGC 23 (2) INFORMATION FOR SEQ ID NO:1280: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 28 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1280: TGTCCGTCCT GTCGCCCTTC CGTGGTGC 28 WO 00/09525 PCT/US99/17712 EPI-109 425 (2) INFORMATION FOR SEQ ID NO:1281: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1281: TGTTGTCTCT TCTGCCCTC 19 (2) INFORMATION FOR SEQ ID NO:1282: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 24 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1282: GGTGTGCTGG TGCTGGTGGT GGTG 24 (2) INFORMATION FOR SEQ ID NO:1283: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1283: CCTCTGCCCG TGCTCGCC 18 (2) INFORMATION FOR SEQ ID NO:1284: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH:- 24 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1284: CTGCCTGGGC TGGCCTCTTC GGGT 24 (2) INFORMATION FOR SEQ ID NO:1285: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 30 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1285: GTGGCTTTGG GGCTCTCTTG GTTGCCCTTT 30 (2) INFORMATION FOR SEQ ID NO:1286: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 35 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1286: CTTCTCGTGG TGCCTCTCCT CCCTGGCTTG GTCGT 35 (2) INFORMATION FOR SEQ ID NO:1287: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 24 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1287: TGTCTGGGGT GGTGCTCCTC TCCC 24 (2) INFORMATION FOR SEQ ID NO:1288: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 20 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1288: TTTCCCTGCT GGCCGTTTGT 20 (2) INFORMATION FOR SEQ ID NO:1289: (i) SEQUENCE CHARACTERISTICS: WO 00/09525 PCT/US99/17712 EPI-109 426 (A) LENGTH: 20 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1289: CCTGTTTTCT GTCTTCCTCT 20 (2) INFORMATION FOR SEQ ID NO:1290: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1290: TTCCTCCTGT TTCTCCGT 18 (2) INFORMATION FOR SEQ ID NO:1291: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 28 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1291: TTGGCTTGCT GCTTGCGGGG CTGTCTCC 28 (2) INFORMATION FOR SEQ ID NO:1292: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 21 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1292: CTTGCCCCTG TGGGCTTTCC C 21 (2) INFORMATION FOR SEQ ID NO:1293: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 25 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1293: TGGTCCGGTC TTCTCCTTGG GGGTC 25 (2) INFORMATION FOR SEQ ID NO:1294: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1294: GCCCTTCTTG GTGGGCTG 18 (2) INFORMATION FOR SEQ ID NO:1295: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1295: GCTCGTCTGT CTTTTTCCTT CC 22 (2) INFORMATION FOR SEQ ID NO:1296: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 34 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1296: TGGGGGTGGC CGTTGTGGGC GGTGTGGTCC GCCT 34 (2) INFORMATION FOR SEQ ID NO:1297: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single WO 00/09525 PCT/US99/17712 EPI-109 427 (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1297: TGCCTCTGCT GGTCTTTC 18 (2) INFORMATION FOR SEQ ID NO:1298: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1298: GTGCTCCGGT GGCTTTTT 18 (2) INFORMATION FOR SEQ ID NO:1299: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 23 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1299: GCTTGTGTGC TCTGCTGTCT CTG 23 (2) INFORMATION FOR SEQ ID NO:1300: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 34 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1300: TTCCTTCCGG TGGTTTCTTC CTGGCTCTTG TCCT 34 (2) INFORMATION FOR SEQ ID NO:1301: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1301: TTCTCTTGGC CCTTGGCCC 19 (2) INFORMATION FOR SEQ ID NO:1302: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 20 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1302: TGGCTCGGTG CTTCTGCCCC 20 (2) INFORMATION FOR SEQ ID NO:1303: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 16 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1303: TGTTGTTGCG GCGCTC 16 (2) INFORMATION FOR SEQ ID NO:1304: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 17 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1304: GGTTGGTGTG GCCCCTG 17 (2) INFORMATION FOR SEQ ID NO:1305: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1305: TGGTGCTTCG TTTCC 15 WO 00/09525 PCT/US99/17712 EPI-109 428 (2) INFORMATION FOR SEQ ID NO:1306: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1306: CCCTCTTTCT CTTTGTTC 18 (2) INFORMATION FOR SEQ ID NO:1307: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1307: GGGGGTTCTT GTGGC 15 (2) INFORMATION FOR SEQ ID NO:1308: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1308: GGGCTGCTTG TCTCGTTCC 19 (2) INFORMATION FOR SEQ ID NO:1309: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH:- 20 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: Genomic DNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1309: GGTCCBGCCB TGGGTCTGGG 20 (2) INFORMATION FOR SEQ ID NO:1310: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 20 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: Genomic DNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1310: GGCTGGGCTG CBGGCTCCGG 20 (2) INFORMATION FOR SEQ ID NO:1311: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 27 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1311: GCGGGCGGGT GCGGGCTGCG TGCTGGG 27 (2) INFORMATION FOR SEQ ID NO:1312: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 20 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1312: GGCTGCCCCG CAGGCCCTGC 20 (2) INFORMATION FOR SEQ ID NO:1313: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 115 base pairs (B) TYPE: nucleic acid (C) 9TRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: Genomic DNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1313: GCBCCGCCTG GBGCCCTGGG GCCCCCCTGT CTTCTTGGGG BGCGCCTCCT CGGCCBGCTC 60 WO 00/09525 PCT/US99/17712 EPI-109 429 CBCGTCCCGG BTCBTGCTTT CBGTGCTCBT GGTGTCCTTT CCBGGGGBGB GBGGG 115 (2) INFORMATION FOR SEQ ID NO:1314: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 331 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: Genomic DNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1314: GCTGGTCCTC TGCTGTCCTT GCTGGTGCTC BTGGTGTCCT TTCCGCCCTG GGGCCCCCCT 60 GTCTTCTTGG GGCCTCTTCC CTCTGGGGGC CGTCTCTCTC CCTCTCTTGC GTCTCTCTCT 120 TTCTCTCTCT CTCTTCCCCT TTCCCGCTCT TTCTGTCTCG GTGTCTGGTT TTCTCTCTCC 180 GCTGGCTGCC TGTCTGGCCT GCGCTCTTGG CCTGTGCTGT TCCTCCTCCG GTTCCTGTCC 240 TCTCTGTCTG TCGCCCCCTC TGGGGTCTCC CTCTGGCGTG GTGGTCTTGT TGCTTGGGCT 300 GGGCTCCGTG TCTCCBGTGC TCBTGGTGTC C 331 (2) INFORMATION FOR SEQ ID NO:1315: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 373 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: Genomic DNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1315: GCTGBGGGBG CGTCTGCTGG CGCTGGTCCT CTGCTGTCCT TGCTGGTGCT CBTGTGTCC 60 TTTCCGCCCT GGGGCCCCCC TGTCTTCTTG GGGCCTCTTC CCTCTGGGGG CCGTCTCTCT 120 CCCTCTCTTG CGTCTCTCTC TTTCTCTCTC TCTCTTCCCC TTTCCCGCTC TTTCTGTCTC 180 GGTGTCTGGT TTTCTCTCTC CGCTGGCTGC CTGTCTGGCC TGCGCTCTTG GCCTGTGCTG 240 TTCCTCCTCC GGTTCCTGTC CTCTCTGTCT GTCGCCCCCT CTGGGGTCTC CCTCTGGCGT 300 GGTGGTCTTG TTGCTTGGGC TGGGCTCCGT GTCTCCBGTG CTCBTGGTGT CCGCTGBGGG 360 BGCGTCTGCT GGC 373 (2) INFORMATION FOR SEQ ID NO:1316: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 25 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1316: GCCCCGTCTG CTGCTCCTCG TGCCG 25 (2) INFORMATION FOR SEQ ID NO:1317: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 33 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear 2 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1317: CCTCGTCCTT CATGGTACCG TCGGTGTGGT GGC 33 (2) INFORMATION FOR SEQ ID NO:1318: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1318: CTCGGGTGGG CCGGTGGTG 19 (2) INFORMATION FOR SEQ ID NO:1319: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1319: GGGCGCGCGC GCTCGCGT 18 (2) INFORMATION FOR SEQ ID NO:1320: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 49 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear WO 00/09525 PCT/US99/17712 EPI-109 430 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1320: GGCTCCGGCT CTTCTTTCCC GGCTCCGTCG GCCCGGGGGC CTTGGTCTC 49 (2) INFORMATION FOR SEQ ID NO:1321: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 20 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: Genomic DNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1321: CCTCGTCCTT CBTGGTBCCG 20 (2) INFORMATION FOR SEQ ID NO:1322: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 16 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1322: CCCGTTCGCC TGGCGC 16 (2) INFORMATION FOR SEQ ID NO:1323: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 16 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1323: GCGCTGCGGG TTCCTC 16 (2) INFORMATION FOR SEQ ID NO:1324: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 23 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1324: GTGGGTTTCT CCCCGCCGTT CTC 23 (2) INFORMATION FOR SEQ ID NO:1325: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 20 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1325: CGGTCTGTTG CCTTTGTGGG 20 (2) INFORMATION FOR SEQ ID NO:1326: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1326: CTTCTTGTCT TTTTGGCT 18 (2) INFORMATION FOR SEQ ID NO:1327: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1327: GTTCTTTTCC TGCTTGGC 18 (2) INFORMATION FOR SEQ ID NO:1328: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1328: GTCTTTTCCT TTCTT 15 WO 00/09525 PCT/US99/17712 EPI-109 431 (2) INFORMATION FOR SEQ ID NO:1329: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1329: TGTGCTCGGT TGTGGGTC 18 (2) INFORMATION FOR SEQ ID NO:1330: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1330: CGCTGGTCCT TTGCC 15 (2) INFORMATION FOR SEQ ID NO:1331: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 16 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1331: CTGTGTGTTT CTGCTG 16 (2) INFORMATION FOR SEQ ID NO:1332: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH:- 16 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1332: CCCGTTCGCC TGGCGC 16 (2) INFORMATION FOR SEQ ID NO:1333: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 16 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1333: GCGCTGCGGG TTCCTC 16 (2) INFORMATION FOR SEQ ID NO:1334: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 23 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1334: GTGGGTTTCT CCCCGCCGTT CTC 23 (2) INFORMATION FOR SEQ ID NO:1335: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 20 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1335: CGGTCTGTTG CCTTTGTGGG 20 (2) INFORMATION FOR SEQ ID NO:1336: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1336: CTTCTTGTCT TTTTGGCT 18 (2) INFORMATION FOR SEQ ID NO:1337: (i) SEQUENCE CHARACTERISTICS: WO 00/09525 PCTIUS99/17712 EPI-109 432 (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1337: GTTCTTTTCC TGCTTGGC 18 (2) INFORMATION FOR SEQ ID NO:1338: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1338: GTCTTTTCCT TTCTT 15 (2) INFORMATION FOR SEQ ID NO:1339: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1339: TGTGCTCGGT TGTGGGTC 18 (2) INFORMATION FOR SEQ ID NO:1340: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1340: CGCTGGTCCT TTGCC 15 (2) INFORMATION FOR SEQ ID NO:1341: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 16 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1341: CTGTGTGTTT CTGCTG 16 (2) INFORMATION FOR SEQ ID NO:1342: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1342: GCGTCCGGTG GCCGCCGC 18 (2) INFORMATION FOR SEQ ID NO:1343: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 17 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1343: GCCTCTCTCC TCTCCCC 17 (2) INFORMATION FOR SEQ ID NO:1344: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1344: GTGGCCCTGT CGGGCGGG 18 (2) INFORMATION FOR SEQ ID NO:1345: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 21 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single WO 00/09525 PCT/US99/17712 EPI-109 433 (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1345: TCCTGCCGTC CTGTCTCCTT T 21 (2) INFORMATION FOR SEQ ID NO:1346: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 16 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1346: TCTTTTGCTG TCTTGT 16 (2) INFORMATION FOR SEQ ID NO:1347: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 17 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1347: CTTCCCGTCT CTGCTTT 17 (2) INFORMATION FOR SEQ ID NO:1348: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 23 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1348: GTCTGTCCTC CCCGTCTCCT CCC 23 (2) INFORMATION FOR SEQ ID NO:1349: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 16 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1349: ACTGCTTCTC CCGGGG 16 (2) INFORMATION FOR SEQ ID NO:1350: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1350: GCTTCCCCGG CTTC 14 (2) INFORMATION FOR SEQ ID NO:1351: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 34 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1351: GGGTGGCCGG TGTCCCGGGC TCCGGCGCGG CGGC 34 (2) INFORMATION FOR SEQ ID NO:1352: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 12 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1352: GGCTTCGGCT GC 12 (2) INFORMATION FOR SEQ ID NO:1353: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1353: GGGTGGGTGG CGCGG 15 WO 00/09525 PCT/US99/17712 EPI-109 434 (2) INFORMATION FOR SEQ ID NO:1354: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 28 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1354: GCTGCCGGGT CCGCGCGGCG CCTGGGCC 28 (2) INFORMATION FOR SEQ ID NO:1355: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1355: CTTGTGCTGC TTTT 14 (2) INFORMATION FOR SEQ ID NO:1356: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1356: TGCTTGTTCC GTTC 14 (2) INFORMATION FOR SEQ ID NO:1357: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH:. 32 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1357: TGGCTGCTCC GGTCTGTGTT GTGGTTGTTT TG 32 (2) INFORMATION FOR SEQ ID NO:1358: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1358: TTTCTTCTTG GGTGTGGG 18 (2) INFORMATION FOR SEQ ID NO:1359: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1359: CCTTGCGGTT TTGG 14 (2) INFORMATION FOR SEQ ID NO:1360: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear. (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1360: CTGTGGGCCC TTTG 14 (2) INFORMATION FOR SEQ ID NO:1361: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1361: GGGCCTTGGC TTCTGGCTC 19 (2) INFORMATION FOR SEQ ID NO:1362: (i) SEQUENCE CHARACTERISTICS: WO 00/09525 PCT/US99/17712 EPI-109 435 (A) LENGTH: 125 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1362: CATCCACATG ATTGCTTAGA TTTGTGCTGT ATCTCTCAGG ATTATCACTG ATTACACATC 60 CAACCAGTGC CAGCCAAAAG GATGCCCTGA GGCAAAGGGT TTCCATCTTG AGGCAAATTT 120 GAGGA 125 (2) INFORMATION FOR SEQ ID NO:1363: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 125 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: Genomic DNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1363: CBTCCBCBTG BTTGCTTBGB TTTGTGCTGT BTCTCTCBGG BTTBTCBCTG BTTBCBCBTC 60 CBBCCBGTGC CBGCCBBBBG GBTGCCCTGB GGCBBBGGGT TTCCBTCTTG BGGCBBBTTT 120 GBGGB 125 (2) INFORMATION FOR SEQ ID NO:1364: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1364: CGTGGTCGCT CCGC 14 (2) INFORMATION FOR SEQ ID NO:1365: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1365: GTTTCTCTGG TTCCTCCG 18 (2) INFORMATION FOR SEQ ID NO:1366: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 16 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1366: GTCCCGCGGG GTGCTG 16 (2) INFORMATION FOR SEQ ID NO:1367: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1367: TCTGGTCGCT GTCGT 15 (2) INFORMATION FOR SEQ ID NO:1368: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1368: GGCTTGGGTC TCCGGGCG 18 (2) INFORMATION FOR SEQ ID NO:1369: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1369: GTTTCCTTCC TTTTCCGC 18 WO 00/09525 PCTIUS99/17712 EPI-109 436 (2) INFORMATION FOR SEQ ID NO:1370: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 24 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1370: GTCCTGTCGT GGCGCCTGGG GCTC 24 (2) INFORMATION FOR SEQ ID NO:1371: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1371: TTCTTTTGTG GGCT 14 (2) INFORMATION FOR SEQ ID NO:1372: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1372: CTTTGGTGGC TGTGGCTG 18 (2) INFORMATION FOR SEQ ID NO:1373: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1373: TGGTCTCTGT GGTTG 15 (2) INFORMATION FOR SEQ ID NO:1374: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1374: CTGCCCTGGG TCTGG 15 (2) INFORMATION FOR SEQ ID NO:1375: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 46 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1375: GGGTGTGGCC TTGGGGCCGT CCTCTGGCTC CTCCTCGTGG GCCCCC 46 (2) INFORMATION FOR SEQ ID NO:1376: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 265 base pairs (H) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1376: GGGCTAAGAT GATCCACATC ACTACCACGT TGCCCACCAC AGAGGTCACC ACAATGACCG 60 TGTAGGCAGC TGCCCAAAGG ACAATTTGCC AGGCTGGTTG CACGAACTGA TTGGGTTCCG 120 AGGTGTTAGT GGAGATGTTT GGGGAGAGGT CTGAGTCCAC CGGGAGGACG TTATCCATTT 180 CGAAGCTAGG CGGTAAAGCC CTACTATCTG TACACAACCC CCCTCTGCAG CAGAGTCCTG 240 TCGTGGCGCC TGGGGCTCAG GGTCC 265 (2) INFORMATION FOR SEQ ID NO:1377: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 265 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: Genomic DNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1377: WO 00/09525 PCT/US99/17712 EPI-109 437 GGGCTBBGBT GBTCCBCBTC BCTBCCBCGT TGCCCBCCBC BGBGGTCBCC BCBBTGBCCG 60 TGTBGGCBGC TGCCCBBBGG BCBBTTTGCC BGGCTGGTTG CBCGBBCTGB TTGGGTTCCG 120 BGGTGTTBGT GGBGBTGTTT GGGGBGBGGT CTGBGTCCBC CGGGBGGBCG TTBTCCBTTT 180 CGBBGCTBGG CGGTBBBGCC CTBCTBTCTG TBCBCBBCCC CCCTCTGCBG CBGBGTCCTG 240 TCGTGGCGCC TGGGGCTCBG GGTCC 265 (2) INFORMATION FOR SEQ ID NO:1378: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1378: CGTTTTCTTC TCTC 14 (2) INFORMATION FOR SEQ ID NO:1379: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 16 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1379: GCTGGTTTTC CTTTCC 16 (2) INFORMATION FOR SEQ ID NO:1380: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 31 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1380: TGGCAGTGGG TGGGGGTGGG GGTGGGGTGG C 31 (2) INFORMATION FOR SEQ ID NO:1381: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 23 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1381: TTCCTTGTTC CTGGGGGTGT CCT 23 (2) INFORMATION FOR SEQ ID NO:1382: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1382: CTTGCTCTGG GCTTTTCT 18 (2) INFORMATION FOR SEQ ID NO:1383: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1383: CCCCTTTTCC TTCC 14 (2) INFORMATION FOR SEQ ID NO:1384: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 17 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1384: TGTCTGTTTT CCTGGGG 17 (2) INFORMATION FOR SEQ ID NO:1385: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear WO 00/09525 PCTIUS99/17712 EPI-109 438 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1385: CTCTCCTCTG TCTCTGTGT 19 (2) INFORMATION FOR SEQ ID NO:1386: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1386: CCTTGCCCTG GCCC 14 (2) INFORMATION FOR SEQ ID NO:1387: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1387: TCTTCCCTCT CCTGTCTCCT GT 22 (2) INFORMATION FOR SEQ ID NO:1388: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1388: CCCTGTGTTC CGCCC 15 (2) INFORMATION FOR SEQ ID NO:1389: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1389: GTCTTCCCTC TCCTG 15 (2) INFORMATION FOR SEQ ID NO:1390: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 16 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear. (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1390: ACCTCCTTTT CCTCCG 16 (2) INFORMATION FOR SEQ ID NO:1391: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1391: CTGGGTGGGG CCCTG 15 (2) INFORMATION FOR SEQ ID NO:1392: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 16 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1392: CCTGTTCTCT GCTCCC 16 (2) INFORMATION FOR SEQ ID NO:1393: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1393: TGGCTTGGGG TTTCTTCTG 19 WO 00/09525 PCT/US99/17712 EPI-109 439 (2) INFORMATION FOR SEQ ID NO:1394: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1394: TGTGTCTTCT TCCTCTGTT 19 (2) INFORMATION FOR SEQ ID NO:1395: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 17 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1395: GGCTGGCTTT CTCCTTC 17 (2) INFORMATION FOR SEQ ID NO:1396: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1396: TTTTGTCTTC CTGGG 15 (2) INFORMATION FOR SEQ ID NO:1397: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1397: TGCCCCTTCT TCCTTTCTTG GG 22 (2) INFORMATION FOR SEQ ID NO:1398: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 20 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1398: TCCTTGGTGC TTGGGCTGGG 20 (2) INFORMATION FOR SEQ ID NO:1399: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1399: CTGTGCGTCC GTCTGCTGG 19 (2) INFORMATION FOR SEQ ID NO:1400: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 31 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1400: GGGGCCGGGG TGGCTGGGCC CTGCTTGCCG C 31 (2) INFORMATION FOR SEQ ID NO:1401: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 21 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1401: ACGACCCCGG GCCGACCCGA G 21 (2) INFORMATION FOR SEQ ID NO:1402: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 31 base pairs WO 00/09525 PCT/US99/17712 EPI-109 440 (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1402: GCTCGGGGGG CTGTGTTCTG GCGCTGGTGG G 31 (2) INFORMATION FOR SEQ ID NO:1403: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 25 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1403: CTTGGGCCCC TCTGGGGGCT GGGTT 25 (2) INFORMATION FOR SEQ ID NO:1404: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 21 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1404: TCCTGCTGCG CCTGGGCGCT G 21 (2) INFORMATION FOR SEQ ID NO:1405: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1405: GCGTCTTGGG GTGC 14 (2) INFORMATION FOR SEQ ID NO:1406: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1406: GGGGCCGGGG GGCCGGGGG 19 (2) INFORMATION FOR SEQ ID NO:1407: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 21 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1407: GCCGCTGTTC GTGGGCCTGG G 21 (2) INFORMATION FOR SEQ ID NO:1408: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 16 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1408: GGTGCCTGTG GCTGCC 16 (2) INFORMATION FOR SEQ ID NO:1409: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1409: GGTTGCCCCG GTTGGTGGC 19 (2) INFORMATION FOR SEQ ID NO:1410: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 17 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear WO 00/09525 PCT/US99/17712 EPI-109 441 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1410: GCCGTCCTGC TGCCGGT 17 (2) INFORMATION FOR SEQ ID NO:1411: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 20 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1411: CGTTGGCTGG GTCCCCCCGC 20 (2) INFORMATION FOR SEQ ID NO:1412: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 16 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1412: CCGTTTCCTG GGGTCC 16 (2) INFORMATION FOR SEQ ID NO:1413: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1413: GCGTGGGGTG CTCC 14 (2) INFORMATION FOR SEQ ID NO:1414: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1414: GGTTCCTCGT GCCG 14 (2) INFORMATION FOR SEQ ID NO:1415: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1415: CTGCTGCCTT GTCTTTCC 18 (2) INFORMATION FOR SEQ ID NO:1416: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1416: GGCCGTGGCG GCGTGGTGGT CC 22 (2) INFORMATION FOR SEQ ID NO:1417: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 21 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1417: GCCCCCCCTG GCCTTCTGCT C 21 (2) INFORMATION FOR SEQ ID NO:1418: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear ' (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1418: GGGGTCTGGC TGGT 14 WO 00/09525 PCTIUS99/17712 EPI-109 442 (2) INFORMATION FOR SEQ ID NO:1419: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1419: TGCCGGTGCC CTTGGCGGC 19 (2) INFORMATION FOR SEQ ID NO:1420: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 16 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1420: GGTCTTCTTC CTGGTG 16 (2) INFORMATION FOR SEQ ID NO:1421: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 23 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear. (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1421: GCTCTGGGCC CGGCCGGTCT CGG 23 (2) INFORMATION FOR SEQ ID NO:1422: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: ftucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1422: GCGTCTCGTG TTCG 14 (2) INFORMATION FOR SEQ ID NO:1423: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 20 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1423: CTCTTGTGCT GTTCCGGCCG 20 (2) INFORMATION FOR SEQ ID NO:1424: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 20 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1424: CTCCTTCCTC TTCCGCCGCC 20 (2) INFORMATION FOR SEQ ID NO:1425: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1425: GCCGCTCCCC GCCC 14 (2) INFORMATION FOR SEQ ID NO:1426: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 17 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1426: GCTCGTCGCC CTGGCCC 17 (2) INFORMATION FOR SEQ ID NO:1427: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 17 base pairs WO 00/09525 PCT/US99/17712 EPI-109 443 (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1427: GGCCTCCTCC TGGCCGC 17 (2) INFORMATION FOR SEQ ID NO:1428: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1428: TGTCTCGGGC GGCGGCCTTG GC 22 (2) INFORMATION FOR SEQ ID NO:1429: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 16 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1429: GCTCCGTTTG GGGCTG 16 (2) INFORMATION FOR SEQ ID NO:1430: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1430: CCTCTGGCGC TTCC 14 (2) INFORMATION FOR SEQ ID NO:1431: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 20 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1431: GGCCCTCGGC CTGGGCGCTC 20 (2) INFORMATION FOR SEQ ID NO:1432: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1432: TCTTCCGCCT GTGC 14 (2) INFORMATION FOR SEQ ID NO:1433: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1433: TGGTGGCCCT CGTGG 15 (2) INFORMATION FOR SEQ ID NO:1434: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 23 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1434: GCCCCTCCTG GCCTCCGGTG TCC 23 (2) INFORMATION FOR SEQ ID NO:1435: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear WO 00/09525 PCT/US99/17712 EPI-109 444 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1435: TGTGGTCCCC CGGCTGGT 18 (2) INFORMATION FOR SEQ ID NO:1436: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 21 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1436: GGCCGGGCCG GTTGGGCGGG C 21 (2) INFORMATION FOR SEQ ID NO:1437: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 21 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1437: GTGGGCGCCG GCGGGTCCTC C 21 (2) INFORMATION FOR SEQ ID NO:1438: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1438: GGGCTGCCCT TCTCC 15 (2) INFORMATION FOR SEQ ID NO:1439: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1439: GCCGGGGGTC CCGC 14 (2) INFORMATION FOR SEQ ID NO:1440: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 29 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1440: GCTCCTGCTG TTCCCTGGGC TCTTCTGCC 29 (2) INFORMATION FOR SEQ ID NO:1441: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 27 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1441: TCTCTCCTGG GTGGGTGCTG GGTGCCG 27 (2) INFORMATION FOR SEQ ID NO:1442: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1442: GGGTCTCCGG GCTTG 15 (2) INFORMATION FOR SEQ ID NO:1443: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 23 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1443: CCCCGCGCTG CTGGGCGTTC TGC 23 WO 00/09525 PCT/US99/17712 EPI-109 445 (2) INFORMATION FOR SEQ ID NO:1444: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1444: GGTCTTGGGG TTGTC 15 (2) INFORMATION FOR SEQ ID NO:1445: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1445: TGTGGCCCCG CTCG 14 (2) INFORMATION FOR SEQ ID NO:1446: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 17 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1446: TGTCGCCCTC CGTCGCC 17 (2) INFORMATION FOR SEQ ID NO:1447: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 17 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1447: CGTCGCCGGC CTCGTCC 17 (2) INFORMATION FOR SEQ ID NO:1448: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1448: CCTCCTGGGT GCGC 14 (2) INFORMATION FOR SEQ ID NO:1449: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1449: GGCGGGCTGG TCCT 14 (2) INFORMATION FOR SEQ ID NO:1450: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 20 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1450: GGCGTTTTGC TCCTTCCTGG 20 (2) INFORMATION FOR SEQ ID NO:1451: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1451: CTGCCTCCCC GGGGT 15 (2) INFORMATION FOR SEQ ID NO:1452: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs WO 00/09525 PCT/US99/17712 EPI-109 446 (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1452: TTCTGCTGCT TGCTG 15 (2) INFORMATION FOR SEQ ID NO:1453: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 16 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1453: CTTCTTTCCC GTCTCC 16 (2) INFORMATION FOR SEQ ID NO:1454: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 16 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1454: CTTCTTTCCC GTCTCC 16 (2) INFORMATION FOR SEQ ID NO:1455: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1455: TTTTTGCCTC TTTG 14 (2) INFORMATION FOR SEQ ID NO:1456: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 16 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1456: GGTTCCTGTT GTTTCT 16 (2) INFORMATION FOR SEQ ID NO:1457: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 16 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1457: GGCCTGCTTG GTGGCG 16 (2) INFORMATION FOR SEQ ID NO:1458: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1458: GCTTGTGCGT TTCC 14 (2) INFORMATION FOR SEQ ID NO:1459: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 36 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1459: TCTCTCTTCT CTTGGGTCTC CGCTTCTCGT CCTGCC 36 (2) INFORMATION FOR SEQ ID NO:1460: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear WO 00/09525 PCTIUS99/17712 EPI-109 447 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1460: TTTTCCTGTC TCTGTCGC 18 (2) INFORMATION FOR SEQ ID NO:1461: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1461: GCCGTTCCTC CTCC 14 (2) INFORMATION FOR SEQ ID NO:1462: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1462: GGCGTCCTCC TGCCC 15 (2) INFORMATION FOR SEQ ID NO:1463: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 17 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1463: TGTGCTGTTT GCCTCGG 17 (2) INFORMATION FOR SEQ ID NO:1464: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1464: GTGGTGCGGG TCCC 14 (2) INFORMATION FOR SEQ ID NO:1465: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1465: GGTGCTCCCC CGGC 14 (2) INFORMATION FOR SEQ ID NO:1466: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 21 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1466: GGGCCGGCTG GTTGCCTGGG C 21 (2) INFORMATION FOR SEQ ID NO:1467: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1467: CTGTCTGGTG GGGTGTGGGG CC 22 (2) INFORMATION FOR SEQ ID NO:1468: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 20 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1468: GCTGGGTTGG GGGTGTGGTG 20 WO 00/09525 PCT/US99/17712 EPI-109 448 (2) INFORMATION FOR SEQ ID NO:1469: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1469: GGCTCTTCTG TGGCC 15 (2) INFORMATION FOR SEQ ID NO:1470: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 16 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1470: TGTGGGGCTG TTGGTG 16 (2) INFORMATION FOR SEQ ID NO:1471: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 16 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1471: TCTCTGTGGG CGTGTG 16 (2) INFORMATION FOR SEQ ID NO:1472: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 17 base pairs (B) TYPE: hucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1472: CTGGGTCTTG GGGCTTC 17 (2) INFORMATION FOR SEQ ID NO:1473: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1473: CTCCCTTGTG CTGGG 15 (2) INFORMATION FOR SEQ ID NO:1474: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (3) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1474: TGCGGCCTCC CCGC 14 (2) INFORMATION FOR SEQ ID NO:1475: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1475: CCCCCTTCTG GGCC 14 (2) INFORMATION FOR SEQ ID NO:1476: (i) SEQUENCE CHARACTERISTICS: *(A) LENGTH: 20 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1476: GGTGGCCTGG CTCCTTGTGG 20 (2) INFORMATION FOR SEQ ID NO:1477: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 16 base pairs WO 00/09525 PCT/US99/17712 EPI-109 449 (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1477: GCGCTTCTGG CTCTTG 16 (2) INFORMATION FOR SEQ ID NO:1478: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 21 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1478: CCCTGTCCTT CTTCGCCTCG T 21 (2) INFORMATION FOR SEQ ID NO:1479: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1479: GGCTGCTGGG CTGC 14 (2) INFORMATION FOR SEQ ID NO:1480: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 17 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1480: GTTGGGCTTG GCCGGGG 17 (2) INFORMATION FOR SEQ ID NO:1481: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1481: CTGCCCGGTG CCTCC 15 (2) INFORMATION FOR SEQ ID NO:1482: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1482: TCTTGGCTGG TCCCTCGT 18 (2) INFORMATION FOR SEQ ID NO:1483: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1483: TGTCCTTGGG CCCC 14 (2) INFORMATION FOR SEQ ID NO:1484: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1484: GCTCCCGCTG CTCGGCCTCC GT 22 (2) INFORMATION FOR SEQ ID NO:1485: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 20 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear WO 00/09525 PCT/US99/17712 EPI-109 450 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1485: GTTCTTTGGC CTCTTGCTCC 20 (2) INFORMATION FOR SEQ ID NO:1486: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 16 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1486: GCCTGCTGTC TTGTCC 16 (2) INFORMATION FOR SEQ ID NO:1487: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 23 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1487: CGTCCCCTCC TCGCTTGCGT TTC 23 (2) INFORMATION FOR SEQ ID NO:1488: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1488: CCTCTTCCTT GTCTTCCA 18 (2) INFORMATION FOR SEQ ID NO:1489: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1489: GGCCTTCCTC CGCTTCCGCT GC 22 (2) INFORMATION FOR SEQ ID NO:1490: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15'base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1490: TGGGGCCCGC GCCGG 15 (2) INFORMATION FOR SEQ ID NO:1491: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 32 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1491: GGGGGCGCTC GGCTCCGCGG CTTCCTCCCC GG 32 (2) INFORMATION FOR SEQ ID NO:1492: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1492: CTGGGGGGTC CTGG 14 (2) INFORMATION FOR SEQ ID NO:1493: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 21 base pairs (B) TYPE: nucleic acid WO 00/09525 PCT/US99/17712 451 (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1493: TCTCCGGGGC CTGCGGCTCG C 21 (2) INFORMATION FOR SEQ ID NO:1494: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 21 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1494: GGGCTCGGGG CTGCGTGCGC C 21 (2) INFORMATION FOR SEQ ID NO:1495: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1495: GCGCGCGGCG TCCGCGGTG 19 (2) INFORMATION FOR SEQ ID NO:1496: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 17 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1496: GGTGGCGCTG TCCCGCC 17 (2) INFORMATION FOR SEQ ID NO:1497: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 32 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1497: GTGGTGTGTC TCCGTTCTCG TCCTGCGCCG TC 32 (2) INFORMATION FOR SEQ ID NO:1498: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1498: CTGGTCTGCC CGTGG 15 (2) INFORMATION FOR SEQ ID NO:1499: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 17 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1499: GGTCCTGGGC GTGGTGG 17 (2) INFORMATION FOR SEQ ID NO:1500: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1500: GGGGCGTCTG GTGC 14 WO 00/09525 PCT/US99/17712 EPI-109 452 (2) INFORMATION FOR SEQ ID NO:1501: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1501: CTCGTCTGCC CCGTG 15 (2) INFORMATION FOR SEQ ID NO:1502: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1502: GGGCTTCGGG CTCGG 15 (2) INFORMATION FOR SEQ ID NO:1503: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 34 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1503: GGCTGTTCGT CCCCCCTGCC GCTCTGTGGC CTCC 34 (2) INFORMATION FOR SEQ ID NO:1504: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 16 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1504: GGGGCTCCTC GTTTTC 16 (2) INFORMATION FOR SEQ ID NO:1505: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 21 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1505: GCTGCTTCGG GTGTCCTTCT C 21 (2) INFORMATION FOR SEQ ID NO:1506: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1506: GGCGTGTGGC CCCGG 15 (2) INFORMATION FOR SEQ ID NO:1507: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 29 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1507: GTCCCGGCCC TGCTGGGCTG GGCGGGGTC 29 (2) INFORMATION FOR SEQ ID NO:1508: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 25 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1508: GCTGCCCTGG GCTTCTGGCC CGTCT 25 WO 00/09525 PCT/US99/17712 EPI-109 453 (2) INFORMATION FOR SEQ ID NO:1509: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1509: GGTTGTCTGT CGGT 14 (2) INFORMATION FOR SEQ ID NO:1510: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1510: GCTTGTCTCG GGTTTCTGG 19 (2) INFORMATION FOR SEQ ID NO:1511: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1511: CCTCTGTGCT GGGC 14 (2) INFORMATION FOR SEQ ID NO:1512: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 20 base pairs (B) TYPE: hucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1512: GCTTCTCTGC CTCCTGCTCC 20 (2) INFORMATION FOR SEQ ID NO:1513: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 16 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1513: GCCCTCCTGG TGGCTC 16 (2) INFORMATION FOR SEQ ID NO:1514: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1514: GGCTGGGGGT GCCCGTGCG 19 (2) INFORMATION FOR SEQ ID NO:1515: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1515: GGGGTGGGTG TGGGGTGTT 19 (2) INFORMATION FOR SEQ ID NO:1516: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 20 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear .(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1516: TTCGGGGTCC TCCCCTTCCC 20 (2) INFORMATION FOR SEQ ID NO:1517: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 20 base pairs WO 00/09525 PCTIUS99/17712 EPI-109 454 (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1517: GTTTCATCTT GGCTTTATCC 20 (2) INFORMATION FOR SEQ ID NO:1518: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1518: TCTCCCCTTG TTCCTCCCC 19 (2) INFORMATION FOR SEQ ID NO:1519: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1519: TCTCCTGCTC TGGRGTCTCC TC 22 (2) INFORMATION FOR SEQ ID NO:1520: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1520: TTCCCTCCCT CCCCTGCC 18 (2) INFORMATION FOR SEQ ID NO:1521: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1521: GTGTTGTCTG TGGGTGTCC 19 (2) INFORMATION FOR SEQ ID NO:1522: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1522: GTTTCGCTCT TGTTGCCC 18 (2) INFORMATION FOR SEQ ID NO:1523: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1523: TGGGCCCTTC CCTGCTGG 18 (2) INFORMATION FOR SEQ ID NO:1524: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1524: GGGGGAGTTT CATCTTGG 18 (2) INFORMATION FOR SEQ ID NO:1525: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear WO 00/09525 PCT/US99/17712 EPI-109 455 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1525: GGGGGBGTTT CBTCTTGGCT TT 22 (2) INFORMATION FOR SEQ ID NO:1526: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 21 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1526: GGGGGBGTTT CBTCTTGGCT T 21 (2) INFORMATION FOR SEQ ID NO:1527: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 20 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1527: GGGGGBGTTT CBTCTTGGCT 20 (2) INFORMATION FOR SEQ ID NO:1528: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1528: GGGGGBGTTT CBTCTTGGC 19 (2) INFORMATION FOR SEQ ID NO:1529: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1529: GGGGGBGTTT CBTCTTGG 18 (2) INFORMATION FOR SEQ ID NO:1530: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 17 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1530: GGGGGBGTTT CBTCTTG 17 (2) INFORMATION FOR SEQ ID NO:1531: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 16 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1531: GGGGGBGTTT CBTCTT 16 (2) INFORMATION FOR SEQ ID NO:1532: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1532: GGGGGBGTTT CBTCT 15 (2) INFORMATION FOR SEQ ID NO:1533: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1533: GGGGGBGTTT CBTC 14 WO 00/09525 PCT/US99/17742 EPI-109 456 (2) INFORMATION FOR SEQ ID NO:1534: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 13 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1534: GGGGGBGTTT CBT 13 (2) INFORMATION FOR SEQ ID NO:1535: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 12 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1535: GGGGGBGTTT CB 12 (2) INFORMATION FOR SEQ ID NO:1536: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 21 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1536: GGGGBGTTTC BTCTTGGCTT T 21 (2) INFORMATION FOR SEQ ID NO:1537: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 20 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1537: GGGGBGTTTC BTCTTGGCTT 20 (2) INFORMATION FOR SEQ ID NO:1538: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1538: GGGGBGTTTC BTCTTGGCT 19 (2) INFORMATION FOR SEQ ID NO:1539: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1539: GGGGBGTTTC BTCTTGGC 18 (2) INFORMATION FOR SEQ ID NO:1540: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 17 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1540: GGGGBGTTTC BTCTTGG 17 (2) INFORMATION FOR SEQ ID NO:1541: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 16 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1541: GGGGBGTTTC BTCTTG 16 (2) INFORMATION FOR SEQ ID NO:1542: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs WO 00/09525 PCTIUS99/17712 EPI-109 457 (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1542: GGGGBGTTTC BTCTT 15 (2) INFORMATION FOR SEQ ID NO:1543: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1543: GGGGBGTTTC BTCT 14 (2) INFORMATION FOR SEQ ID NO:1544: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 13 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1544: GGGGBGTTTC BTC 13 (2) INFORMATION FOR SEQ ID NO:1545: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 12 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1545: GGGGBGTTTC BT 12 (2) INFORMATION FOR SEQ ID NO:1546: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 20 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1546: GGGBGTTTCB TCTTGGCTTT 20 (2) INFORMATION FOR SEQ ID NO:1547: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1547: GGGBGTTTCB TCTTGGCTT 19 (2) INFORMATION FOR SEQ ID NO:1548: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1548: GGGBGTTTCB TCTTGGCT 18 (2) INFORMATION FOR SEQ ID NO:1549: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 17 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1549: GGGBGTTTCB TCTTGGC 17 (2) INFORMATION FOR SEQ ID NO:1550: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 16 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single WO 00/09525 PCTIUS99/17712 EPI-109 458 (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1550: GGGBGTTTCB TCTTGG 16 (2) INFORMATION FOR SEQ ID NO:1551: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1551: GGGBGTTTCB TCTTG 15 (2) INFORMATION FOR SEQ ID NO:1552: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear * (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1552: GGGBGTTTCB TCTT 14 (2) INFORMATION FOR SEQ ID NO:1553: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 13 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1553: GGGBGTTTCB TCT 13 (2) INFORMATION FOR SEQ ID NO:1554: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 12 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1554: GGGBGTTTCB TC 12 (2) INFORMATION FOR SEQ ID NO:1555: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1555: GGBGTTTCBT CTTGGCTTT 19 (2) INFORMATION FOR SEQ ID NO:1556: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1556: GGBGTTTCBT CTTGGCTT 18 (2) INFORMATION FOR SEQ ID NO:1557: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 17 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1557: GGBGTTTCBT CTTGGCT 17 (2) INFORMATION FOR SEQ ID NO:1558: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 16 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1558: GGBGTTTCBT CTTGGC 16 WO 00/09525 PCT/JS99/17712 EPI-109 459 (2) INFORMATION FOR SEQ ID NO:1559: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1559: GGBGTTTCBT CTTGG 15 (2) INFORMATION FOR SEQ ID NO:1560: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1560: GGBGTTTCBT CTTG 14 (2) INFORMATION FOR SEQ ID NO:1561: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 13 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1561: GGBGTTTCBT CTT 13 (2) INFORMATION FOR SEQ ID NO:1562: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 12 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1562: GGBGTTTCBT CT 12 (2) INFORMATION FOR SEQ ID NO:1563: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1563: GBGTTTCBTC TTGGCTTT 18 (2) INFORMATION FOR SEQ ID NO:1564: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 17 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1564: GBGTTTCBTC TTGGCTT 17 (2) INFORMATION FOR SEQ ID NO:1565: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 16 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1565: GBGTTTCBTC TTGGCT 16 (2) INFORMATION FOR SEQ ID NO:1566: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1566: GBGTTTCBTC TTGGC 15 (2) INFORMATION FOR SEQ ID NO:1567: (i) SEQUENCE CHARACTERISTICS: WO 00/09525 PCT/US99/17712 EPI-109 460 (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1567: GBGTTTCBTC TTGG 14 (2) INFORMATION FOR SEQ ID NO:1568: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 13 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1568: GBGTTTCBTC TTG 13 (2) INFORMATION FOR SEQ ID NO:1569: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 12 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1569: GBGTTTCBTC TT 12 (2) INFORMATION FOR SEQ ID NO:1570: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 17 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1570: BGTTTCBTCT TGGCTTT 17 (2) INFORMATION FOR SEQ ID NO:1571: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 16 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1571: BGTTTCBTCT TGGCTT 16 (2) INFORMATION FOR SEQ ID NO:1572: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 16 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1572: BGTTTCBTCT TGGCTT 16 (2) INFORMATION FOR SEQ ID NO:1573: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1573: BGTTTCBTCT TGGCT 15 (2) INFORMATION FOR SEQ ID NO:1574: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1574: BGTTTCBTCT TGGC 14 (2) INFORMATION FOR SEQ ID NO:1575: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 13 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear WO 00/09525 PCTIUS99/17712 EPI-109 461 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1575: BGTTTCBTCT TGG 13 (2) INFORMATION FOR SEQ ID NO:1576: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 12 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1576: BGTTTCBTCT TG 12 (2) INFORMATION FOR SEQ ID NO:1577: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 16 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1577: GTTTCBTCTT GGCTTT 16 (2) INFORMATION FOR SEQ ID NO:1578: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1578: GTTTCBTCTT GGCTT 15 (2) INFORMATION FOR SEQ ID NO:1579: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1579: GTTTCBTCTT GGCT 14 (2) INFORMATION FOR SEQ ID NO:1580: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 13 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1580: GTTTCBTCTT GGC 13 (2) INFORMATION FOR SEQ ID NO:1581: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 12 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1581: GTTTCBTCTT GG 12 (2) INFORMATION FOR SEQ ID NO:1582: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1582: TTTCBTCTTG GCTTT 15 (2) INFORMATION FOR SEQ ID NO:1583: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1583: TTTCBTCTTG GCTT 14 WO 00/09525 PCT/US99/17712 EPI-109 462 (2) INFORMATION FOR SEQ ID NO:1584: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 13 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1584: TTTCBTCTTG GCT 13 (2) INFORMATION FOR SEQ ID NO:1585: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 12 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1585: TTTCBTCTTG GC 12 (2) INFORMATION FOR SEQ ID NO:1586: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear ' (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1586: TTCBTCTTGG CTTT 14 (2) INFORMATION FOR SEQ ID NO:1587: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 13 base pairs (H) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1587: TTCBTCTTGG CTT 13 (2) INFORMATION FOR SEQ ID NO:1588: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 12 base pairs (H) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1588: TTCBTCTTGG CT 12 (2) INFORMATION FOR SEQ ID NO:1589: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 13 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1589: TCBTCTTGGC TTT 13 (2) INFORMATION FOR SEQ ID NO:1590: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 12 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1590: TCBTCTTGGC TT 12 (2) INFORMATION FOR SEQ ID NO:1591: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1591: GGGGGBGTTT CBTCTTGGCT TT 22 (2) INFORMATION FOR SEQ ID NO:1592: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 21 base pairs WO 00/09525 PCT/US99/17712 EPI-109 463 (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1592: GGGGBGTTTC BTCTTGGCTT T 21 (2) INFORMATION FOR SEQ ID NO:1593: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 20 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1593: GGGBGTTTCB TCTTGGCTTT 20 (2) INFORMATION FOR SEQ ID NO:1594: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1594: GGBGTTTCBT CTTGGCTTT 19 (2) INFORMATION FOR SEQ ID NO:1595: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1595: GBGTTTCBTC TTGGCTTT 18 (2) INFORMATION FOR SEQ ID NO:1596: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 17 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1596: BGTTTCBTCT TGGCTTT 17 (2) INFORMATION FOR SEQ ID NO:1597: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 16 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1597: GTTTCBTCTT GGCTTT 16 (2) INFORMATION FOR SEQ ID NO:1598: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1598: TTTCBTCTTG GCTTT 15 (2) INFORMATION FOR SEQ ID NO:1599: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1599: TTCBTCTTGG CTTT 14 (2) INFORMATION FOR SEQ ID NO:1600: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 13 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear WO 00/09525 PCT/US99/17712 EPI-109 464 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1600: TCBTCTTGGC TTT 13 (2) INFORMATION FOR SEQ ID NO:1601: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 12 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1601: CBTCTTGGCT TT 12 (2) INFORMATION FOR SEQ ID NO:1602: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 21 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1602: GGGGGBGTTT CBTCTTGGCT T 21 (2) INFORMATION FOR SEQ ID NO:1603: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 20 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1603: GGGGBGTTTC BTCTTGGCTT 20 (2) INFORMATION FOR SEQ ID NO:1604: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1604: GGGBGTTTCB TCTTGGCTT 19 (2) INFORMATION FOR SEQ ID NO:1605: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1605: GGBGTTTCBT CTTGGCTT 18 (2) INFORMATION FOR SEQ ID NO:1606: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 17 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1606: GBGTTTCBTC TTGGCTT 17 (2) INFORMATION FOR SEQ ID NO:1607: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 16 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1607: BGTTTCBTCT TGGCTT 16 (2) INFORMATION FOR SEQ ID NO:1608: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1608: GTTTCBTCTT GGCTT 15 WO 00/09525 PCTIUS99/17712 EPI-109 465 (2) INFORMATION FOR SEQ ID NO:1609: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1609: TTTCBTCTTG GCTT 14 (2) INFORMATION FOR SEQ ID NO:1610: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 13 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1610: TTCBTCTTGG CTT 13 (2) INFORMATION FOR SEQ ID NO:1611: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 12 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1611: TCBTCTTGGC TT 12 (2) INFORMATION FOR SEQ ID NO:1612: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 20 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1612: GGGGGBGTTT CBTCTTGGCT 20 (2) INFORMATION FOR SEQ ID NO:1613: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1613: GGGGBGTTTC BTCTTGGCT 19 (2) INFORMATION FOR SEQ ID NO:1614: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1614: GGGBGTTTCB TCTTGGCT 18 (2) INFORMATION FOR SEQ ID NO:1615: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 17 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1615: GGBGTTTCBT CTTGGCT 17 (2) INFORMATION FOR SEQ ID NO:1616: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 16 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1616: GBGTTTCBTC TTGGCT 16 (2) INFORMATION FOR SEQ ID NO:1617: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs WO 00/09525 PCTUS9917712 EPI-109 466 (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear . (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1617: BGTTTCBTCT TGGCT 15 (2) INFORMATION FOR SEQ ID NO:1618: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1618: GTTTCBTCTT GGCT 14 (2) INFORMATION FOR SEQ ID NO:1619: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 13 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1619: TTTCBTCTTG GCT 13 (2) INFORMATION FOR SEQ ID NO:1620: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 12 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1620: TTCBTCTTGG CT 12 (2) INFORMATION FOR SEQ ID NO:1621: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1621: GGGGGBGTTT CBTCTTGGC 19 (2) INFORMATION FOR SEQ ID NO:1622: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1622: GGGGBGTTTC BTCTTGGC 18 (2) INFORMATION FOR SEQ ID NO:1623: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 17 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1623: GGGBGTTTCB TCTTGGC 17 (2) INFORMATION FOR SEQ ID NO:1624: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 16 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1624: GGBGTTTCBT CTTGGC 16 (2) INFORMATION FOR SEQ ID NO:1625: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear WO 00/09525 PCT/US99/17712 EPI-109 467 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1625: GBGTTTCBTC TTGGC 15 (2) INFORMATION FOR SEQ ID NO:1626: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1626: BGTTTCBTCT TGGC 14 (2) INFORMATION FOR SEQ ID NO:1627: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 13 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1627: GTTTCBTCTT GGC 13 (2) INFORMATION FOR SEQ ID NO:1628: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 12 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1628: TTTCBTCTTG GC 12 (2) INFORMATION FOR SEQ ID NO:1629: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1629: GGGGGBGTTT CBTCTTGG 18 (2) INFORMATION FOR SEQ ID NO:1630: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 17 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1630: GGGGBGTTTC BTCTTGG 17 (2) INFORMATION FOR SEQ ID NO:1631: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 16 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1631: GGGBGTTTCB TCTTGG 16 (2) INFORMATION FOR SEQ ID NO:1632: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1632: GGBGTTTCBT CTTGG 15 (2) INFORMATION FOR SEQ ID NO:1633: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1633: GBGTTTCBTC TTGG 14 WO 00/09525 PCT/US99/17712 EPI-109 468 (2) INFORMATION FOR SEQ ID NO:1634: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 13 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1634: BGTTTCBTCT TGG 13 (2) INFORMATION FOR SEQ ID NO:1635: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 12 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1635: GTTTCBTCTT GG 12 (2) INFORMATION FOR SEQ ID NO:1636: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 17 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1636: GGGGGBGTTT CBTCTTG 17 (2) INFORMATION FOR SEQ ID NO:1637: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 16 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1637: GGGGBGTTTC BTCTTG 16 (2) INFORMATION FOR SEQ ID NO:1638: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1638: GGGBGTTTCB TCTTG 15 (2) INFORMATION FOR SEQ ID NO:1639: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1639: GGBGTTTCBT CTTG 14 (2) INFORMATION FOR SEQ ID NO:1640: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 13 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1640: GBGTTTCBTC TTG 13 (2) INFORMATION FOR SEQ ID NO:1641: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 12 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1641: BGTTTCBTCT TG 12 (2) INFORMATION FOR SEQ ID NO:1642: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 16 base pairs WO 00/09525 PCTIUS99/17712 EPI-109 469 (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1642: GGGGGBGTTT CBTCTT 16 (2) INFORMATION FOR SEQ ID NO:1643: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1643: GGGGBGTTTC BTCTT 15 (2) INFORMATION FOR SEQ ID NO:1644: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1644: GGGBGTTTCB TCTT 14 (2) INFORMATION FOR SEQ ID NO:1645: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1645: GGGBGTTTCB TCTT 14 (2) INFORMATION FOR SEQ ID NO:1646: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 13 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1646: GGBGTTTCBT CTT 13 (2) INFORMATION FOR SEQ ID NO:1647: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 12 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1647: GBGTTTCBTC TT 12 (2) INFORMATION FOR SEQ ID NO:1648: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1648: GGGGGBGTTT CBTCT 15 (2) INFORMATION FOR SEQ ID NO:1649: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid .(C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1649: GGGGBGTTTC BTCT 14 (2) INFORMATION FOR SEQ ID NO:1650: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 13 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear WO 00/09525 PCT/US99/17712 EPI-109 470 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1650: GGGBGTTTCB TCT 13 (2) INFORMATION FOR SEQ ID NO:1651: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 12 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1651: GGBGTTTCBT CT 12 (2) INFORMATION FOR SEQ ID NO:1652: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1652: GGGGGBGTTT CBTC 14 (2) INFORMATION FOR SEQ ID NO:1653: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 13 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1653: GGGGBGTTTC BTC 13 (2) INFORMATION FOR SEQ ID NO:1654: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 12 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1654: GGGBGTTTCB TC 12 (2) INFORMATION FOR SEQ ID NO:1655: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 13 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1655: GGGGGBGTTT CBT 13 (2) INFORMATION FOR SEQ ID NO:1656: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 12 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1656: GGGGBGTTTC BT 12 (2) INFORMATION FOR SEQ ID NO:1657: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 12 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1657: GGGGGBGTTT CB 12 (2) INFORMATION FOR SEQ ID NO:1658: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1658: TCTCCCCTTG TTCCTCCCC 19 WO 00/09525 PCT/US99/17712 trl-lu9 471 (2) INFORMATION FOR SEQ ID NO:1659: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1659: TCTCCTGCTC TGGTGTCTCC TC 22 (2) INFORMATION FOR SEQ ID NO:1660: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1660: TTCCCTCCCT CCCCTGCC 18 (2) INFORMATION FOR SEQ ID NO:1661: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1661: GTGTTGTCTG TGGGTGTCC 19 (2) INFORMATION FOR SEQ ID NO:1662: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1662: GTTTCGCTCT TGTTGCCC 18 (2) INFORMATION FOR SEQ ID NO:1663: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1663: TGGGCCCTTC CCTGCTGG 18 (2) INFORMATION FOR SEQ ID NO:1664: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 24 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1664: GCTGGTCCTC TGCTGTCCTT GCTG 24 (2) INFORMATION FOR SEQ ID NO:1665: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 20 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1665: GTGCTCBTGG TGTCCTTTCC 20 (2) INFORMATION FOR SEQ ID NO:1666: (i) SEQUENCE CHARACTERISTICS: .(A) LENGTH: 28 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1666: GCCCTGGGGC CCCCCTGTCT TCTTGGGG 28 (2) INFORMATION FOR SEQ ID NO:1667: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 20 base pairs WO 00/09525 PCTIUS99/17712 EPI-109 472 (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1667: CCTCTTCCCT CTGGGGGCCG 20 (2) INFORMATION FOR SEQ ID NO:1668: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 25 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1668: TCTCTCTCCC TCTCTTGCGT CTCTC 25 (2) INFORMATION FOR SEQ ID NO:1669: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1669: TCTTTCTCTC TCTCTCTTCC CC 22 (2) INFORMATION FOR SEQ ID NO:1670: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 20 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1670: TTTCCCGCTC TTTCTGTCTC 20 (2) INFORMATION FOR SEQ ID NO:1671: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 21 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1671: GGTGTCTGGT TTTCTCTCTC C 21 (2) INFORMATION FOR SEQ ID NO:1672: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 28 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1672: GCTGGCTGCC TGTCTGGCCT GCGCTCTT 28 (2) INFORMATION FOR SEQ ID NO:1673: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1673: GGCCTGTGCT GTTCCTCC 18 (2) INFORMATION FOR SEQ ID NO:1674: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 26 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1674: TCCGGTTCCT GTCCTCTCTG TCTGTC 26 (2) INFORMATION FOR SEQ ID NO:1675: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 25 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear WO 00/09525 PCT/US99/17712 EPI-109 473 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1675: GCCCCCTCTG GGGTCTCCCT CTGGC 25 (2) INFORMATION FOR SEQ ID NO:1676: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1676: GTGGTGGTCT TGTTGCTT 18 (2) INFORMATION FOR SEQ ID NO:1677: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1677: GGGCTGGGCT CCGTGTCTC 19 (2) INFORMATION FOR SEQ ID NO:1678: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 17 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1678: CBGTGCTCBT GGTGTCC 17 (2) INFORMATION FOR SEQ ID NO:1679: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 21 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1679: GCTGBGGGBG CGTCTGCTGG C 21 (2) INFORMATION FOR SEQ ID NO:1680: (i) SEQUENCE CHARACTERISTICS: CA) LENGTH: 329 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1680: TGCTTTTCTT TTCTGGGCCT CTGTGGTCTG TTTTTTTCTG GCCCTGCTGG GGCGCTCTCC 60 GCCGCCCGCC TGGCTCCCGG BGCCCBTGBT GGGCBTGCCG TGGTTCTTGC CCTCCTTTGG 120 CTGCCGTGCC CGCTCCCCGG CCTCCTGGCG GGTGGCCGTT GGGCCCGTGT TCCCCTGGGG 180 CCTGGGGCTC CCTTCTCTCG CCCTTCTTGC TGGGCCTCTG CTGCTGCTGG TGCTGTGGCC 240 CCCGTACACC GAGGAGCCCA TGATGGGCAT GCCACAGACG ACAGGCGTHC BCCGBGGBGC 300 CCBTGBTGGG CBTGCCBCBG BCGBCBGGC 329 (2) INFORMATION FOR SEQ ID NO:1681: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 9 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1681: CTGGGCCTC 9 (2) INFORMATION FOR SEQ ID NO:1682: (i) SEQUENCE CHARACTERISTICS: CA) LENGTH: 12 base pairs -(B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1682: GCCGCCCGCC TG 12 (2) INFORMATION FOR SEQ ID NO:1683: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid WO 00/09525 PCTIUS99/17712 EPI-109 474 (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1683: GCCCGCTCCC CGGC 14 (2) INFORMATION FOR SEQ ID NO:1684: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 13 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1684: CBCCGBGGBG CCC 13 (2) INFORMATION FOR SEQ ID NO:1685: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 304 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1685: GGCGCCGTGC CGCGTCTTGG TGGCGGCGGG TTCGCGCCCG CGCGGGGCCC CTCCGGTCCG 60 TTCGCGCCCG CGCGGGGCCC CTCCGGTCCC GGGTCGGGGC CCCCCGCGGC CGCCTCGGGG 120 CTGGGGCGCT GGTGGCCGGG CCGCGCCTCC GCCTGCCGCT TCTGGCTGGG CCCCGGGCGC 180 CCCCTCCCCT CTTGCTCGGG TCCCCGTGAC AGCGCGTCCT GTGTCTCCAG CAGCATGGCC 240 GGGCCAGCTG GGCCCCBCBG CGCGTCCTGT GTCTCCBGCB GCBTGGCCGG GCCBGCTGGG 300 CCCC 304 (2) INFORMATION FOR SEQ ID NO:1686: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 10 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1686: GCGCGTCCTG 10 (2) INFORMATION FOR SEQ ID NO:1687: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 12 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1687: GCTGGGCCCC GG 12 (2) INFORMATION FOR SEQ ID NO:1688: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 16 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1688: CGGGTCGGGG CCCCCC 16 (2) INFORMATION FOR SEQ ID NO:1689: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 10 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1689: CGCGCCCGCG 10 (2) INFORMATION FOR SEQ ID NO:1690: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 213 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear . (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1690: ACAGAGCAGT GCTGTTGTTG GGCATCTTGC CTTCCCAGGG BCBGBGCBTG CTGTTGTTGG 60 GCBTCTTGCC TTCCCBGGGC CCTTTTCTGG TGGGGTGGTG CTGTTGTTGG GCTTTCTTCT 120 GTTCCCBCBG BGCBGTGCTG TTGTTGGGCB TCTTGCCTTC CCBGGGCCCT TTTCTGGTGG 180 GGTGGTGCTG TTGTTGGGCT TTCTTCTGTT CCC 213 WO 00/09525 PCT/US99/17712 EPI-109 475 (2) INFORMATION FOR SEQ ID NO:1691: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 8 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1691: GBGCBTGC 8 (2) INFORMATION FOR SEQ ID NO:1692: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 9 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1692: TTGTTGGGC 9 (2) INFORMATION FOR SEQ ID NO:1693: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 13 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1693: TGCCTTCCCB GGG 13 (2) INFORMATION FOR SEQ ID NO:1694: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 133 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1694: TTTCCCCTGG GTCTTCCCTC CTGCTCTTTT TTCATTTGCT CTCCTATTAC TTTCTGTGTC 60 CATTTTTTCA TTAACCGAGC TGTBTTTGCT CTCCTBTTBC TTTCTGTGTC CBTTTTTTCB 120 TTBBCCGBGC TGT 133 (2) INFORMATION FOR SEQ ID NO:1695: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 8 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)' SEQUENCE DESCRIPTION: SEQ ID NO:1695: CCCCTGGG 8 (2) INFORMATION FOR SEQ ID NO:1696: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 11 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1696: GCTCTCCTBT T 11 (2) INFORMATION FOR SEQ ID NO:1697: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1697: CBTTBBCCGB GCTG 14 (2) INFORMATION FOR SEQ ID NO:1698: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 299 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1698: GCCTGTGTCT GTCCTCCTGC TTCGTTCCTC TCGTTCCTGC TTGGTGCCCT TGCCGGTCCT 60 GCTCCTCCGG GCTGTGGGTC GTGGCCCTGG CTCCGGCTGG TGGGCTCCCC TGGCCTTCGC 120 WO 00/09525 PCT/US99/17712 hrl-IU9 476 TGGCTGGCGG CGTGCGGGTC TTGCTCTGGG CCTGGCTGTG GCCGTGGTTG GGGGTCTTCG 180 CTGCCTCCGT TTGGGTGGCT CTCTGAATAT TGACCTTCCT CCATGGCGGT CCTGCTTGGA 240 TTCTCCCGAT CTCTGBBTBT TGBCCTTCCT CCBTGGCGGT CCTGCTTGGB TTCTCCCGB 299 (2) INFORMATION FOR SEQ ID NO:1699: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 8 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1699: GTCCTCCT 8 (2) INFORMATION FOR SEQ ID NO:1700: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1700: TGTGTCTGTC CTCC 14 (2) INFORMATION FOR SEQ ID NO:1701: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 11 base pairs (3) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1701: GTGGCCCTGG C 11 (2) INFORMATION FOR SEQ ID NO:1702: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 11 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1702: CGTGGTTGGG G 11 (2) INFORMATION FOR SEQ ID NO:1703: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 16 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1703: TCTCTGBBTB TTGBCC 16 (2) INFORMATION FOR SEQ ID NO:1704: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 378 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1704: GCCTTTCCTG GTTCTCTTGT TGTTTTTGGG GTTTGGCTTA CAGTAGAGTA GGGGATTCCA 60 TGGCAGGAGC CATCTTCTTC ATGGACTCCT TCAAGGAGAC CTTAGGTTTC TGAGGGACTG 120 CTAACACGCC ATCTGGAGCB CBGTBGBGTB GGGGBTTCCB TGGCBGGBGC CBTCTTCTTC 180 BTGGBCTCCT TCBBGGBGBC CTTBGGTTTC TGBGGGBCTG CTBBCBCGCC BTCTGGBGCG 240 TTGTTTTTGG GGTTTGGCTT GCCTTTCCTG GTTCTCTTBC BGTBGBGTBG GGGBTTCCBT 300 GGCBGGBGCC BTCTTCTTCB TGGBCTCCTT CBBGGBGBCC TTBGGTTTCT GBGGGBCTGC 360 TBBCBCGCCB TCTGGBGC 378 (2) INFORMATION FOR SEQ ID NO:1705: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 8 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1705: TGGBCTCC 8 (2) INFORMATION FOR SEQ ID NO:1706: (i) SEQUENCE CHARACTERISTICS: WO 00/09525 PCT/US99/17712 EPI-109 477 (A) LENGTH: 9 base pairs (B) TYPE: nucieic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1706: CCBTCTGGB 9 (2) INFORMATION FOR SEQ ID NO:1707: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 11 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1707: CTGCTBBCBC G 11 (2) INFORMATION FOR SEQ ID NO:1708: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1708: GTTTTTGGGG TTTG 14 (2) INFORMATION FOR SEQ ID NO:1709: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 279 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: Genomic DNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1709: GCCTGTGTCT GTCCTCCTGC TTCGTTCCTC TCGTTCCTGC TTGGTGCCCT TGCCGGTCCT 60 GCTCCTCCGG GCTGTGGGTC CTCGCCCTGG CTCCGGCTGG TGGGCTCCCC TGGCCTTCGC 120 TGGCTGGCGG CGTGCCCCBG BBCGBGBCCC GGBCCGBCBG GCCGTGGTTG GGGGTCTTCG 180 CTGCCTCCGT TTGGGTGGCG ATCTCTGAAT ATTGACCTTC CATGGCGGTC CTGCTTGGAG 240 BTCTCTGBBT BTTGBCCTTC CBTGGCGGTC CTGCTTGGB 279 (2) INFORMATION FOR SEQ ID NO:1710: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 291 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1710: GCCTGTGTCT GTCCTCCTGC TTCGTTCCTC TCGTTCCTGC TTGGTGCCCT TGCCGGTCCT 60 GCTCCTCCGG GCTGTGGGTC CTCGCCCTGG CTCCGGCTGG TGGGCTCCCC TGGCCTTCGC 120 TGGCTGGCGG CGTGCCCCBG BBCGBGBCCC GGBCCGBCBG GCCGTGGTTG GGGGTCTTCG 180 CTGCCTCCGT TTGGGTGGCG ATCTCTGAAT ATTGACCTTC CATGGCGGTC CTGCTTGGAG 240 BTCTCTGBBT BTTGBCCTTC CBTGGCGGTC CTGCTTGGBT CGTTCCTCTC G 291 (2) INFORMATION FOR SEQ ID NO:1711: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 10 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1711: BGBBCGBGBC 10 (2) INFORMATION FOR SEQ ID NO:1712: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 10 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1712: TGBBTBTTGB 10 (2) INFORMATION FOR SEQ ID NO:1713: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 171 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single WO 00/09525 PCT/US99/17712 EPI-109 478 (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1713: TCTCCCTTGG GCTCTGGCTC CTTCTCTCTC TCTCCCTCTC TCTCTGTCGC CTCCGCCCTG 60 GCTGCTGGGG TGGTGGTGCT TTTGTTCTTC CTTGCTGCCG CCCCGCTGCT TGTCTTCCTC 120 GCTCTGTCCC TCTCTCTCTG TBCTCCTCBG GCTCCBTCBT CTCCCTTGGG C 171 (2) INFORMATION FOR SEQ ID NO:1714: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 9 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1714: GGCTCTGGC 9 (2) INFORMATION FOR SEQ ID NO:1715: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 7 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1715: CCCTTGG 7 (2) INFORMATION FOR SEQ ID NO:1716: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 11 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1716: TTTGTTCTTC C 11 (2) INFORMATION FOR SEQ ID NO:1717: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 123 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1717: CTTGCTCCTG GGGGCCTCCT GGTCCCTCCG GGTGTTCCCG GCGGGCCTGG CCTGGGGCBG 60 GGGCCGCGTB GGCGCGGCTC GCCBGGBCGG GCBGCGCCBG CBGCBGCBGB TTCBGCBTCC 120 TGG 123 (2) INFORMATION FOR SEQ ID NO:1718: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1718: GCTCCTGGGG GCCT 14 (2) INFORMATION FOR SEQ ID NO:1719: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 9 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1719: CGTBGGCGC 9 (2) INFORMATION FOR SEQ ID NO:1720: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 10 base pairs *(B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1720: TGGCCTGGGG 10 (2) INFORMATION FOR SEQ ID NO:1721: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 132 base pairs (B) TYPE: nucleic acid WO 00/09525 PCT/US99/17712 EPI-109 479 (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1721: CTTGCTCCTG GGGGCCTCCT GGTCCCTCTG GCTGTTCCCG GCCCTGGBCT GGGGCBGGGG 60 CCGCGTBGGC GCGGCTCGCC BGGBCGGGCB GCGCCBGCBG CBGCBGGCTC BGCBTCCTGG 120 CCBCGGBBTT CC 132 (2) INFORMATION FOR SEQ ID NO:1722: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 17 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1722: CTCCTGGGGG CCTCCTG 17 (2) INFORMATION FOR SEQ ID NO:1723: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1723: BTCCTGGCCB CGGBBTTCC 19 (2) INFORMATION FOR SEQ ID NO:1724: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 7 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear' (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1724: GTCCCTC 7 (2) INFORMATION FOR SEQ ID NO:1725: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 180 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1725: GGTGTGCGGG GCCTGGTGCC CCTGGGCCTC GGGTGCTGCC TGTGCGCTGC CTTCTTCTCC 60 TGGGTCCTCG CCGGGGCCCT TGCTGCCCTG GCTGTGCCCT GGGGGTCTGG GTTCGGCTGT 120 CCCCBGCBGG BCCBGTCCCB TCCBCBGCGT GTGBTGBGTB GCCBTTCTCC TGCBGCCGBG 180 (2) INFORMATION FOR SEQ ID NO:1726: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 16 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1726: TTCTCCTGCB GCCGBG 16 (2) INFORMATION FOR SEQ ID NO:1727: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 17 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1727: CTTGCTGCCC TGGCTGT 17 (2) INFORMATION FOR SEQ ID NO:1728: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 11 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1728: TCTTCTCCTG G 11 (2) INFORMATION FOR SEQ ID NO:1729: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 101 base pairs WO 00/09525 PCT/US99/17712 EPI-109 480 (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1729: GGGCGCGGGC GBGCBTCGCT TTGGGCTTTT CTCCTTTGGT TTGBGCGCCB GGBCCGCGCB 60 CBGCBGCBGG GCGCGGGCGB GCBTCGCBGC GGCGGGCBGG G 101 (2) INFORMATION FOR SEQ ID NO:1730: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 7 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1730: GGCBGGG 7 (2) INFORMATION FOR SEQ ID NO:1731: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 10 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1731: TCCTTTGGTT 10 (2) INFORMATION FOR SEQ ID NO:1732: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 81 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1732: CCTCCTTCCT GGTCTGTCTG CCBGBCBBBT TTGGGBBGTG BBCBGTTTTG GBBCCBTGTT 60 TCCCBGTCTC TGBGCTGTGG C 81 (2) INFORMATION FOR SEQ ID NO:1733: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 13 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1733: TTCTCCTTTG GTT 13 (2) INFORMATION FOR SEQ ID NO:1734: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1734: TTTCTCCTTT GGTT 14 (2) INFORMATION FOR SEQ ID NO:1735: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 156 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1735: GCCCTGCTGC TCTTTCTGCT TCCCTTGGTG GGTTGGGCCG CTGGTTGTTC TGGGGTTCTT 60 GCTGCCCCTT CTGTCCCTGT TTGCTGGTGT CTGCGCCCCC BBCBGBBGBB GCBGBCBBBT 120 TTGGGBBGTG BBCBGTTTTG GBBCCBTGTT TCCTGT 156 (2) INFORMATION FOR SEQ ID NO:1736: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 7 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1736: TTCCTGT 7 (2) INFORMATION FOR SEQ ID NO:1737: (i) SEQUENCE CHARACTERISTICS: WO 00/09525 PCT/US99/17712 EPI-109 481 (A) LENGTH: 11 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1737: CTCTTTCTGC T (2) INFORMATION FOR SEQ ID NO:1738: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 13 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1738: CCCCTTCTGT CCC 13 (2) INFORMATION FOR SEQ ID NO:1739: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 272 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1739: GCGCTCGGCC TGGTCCCGGG GGTCTCCTCT TGTTGTTGCT TGCGCCTCCT GCTGGGGGTC 60 CCTCTGTTCT TGTTTTGGGG GCGGGCCCGG CCGTTGTCTT GGTTTGGGGG TTTCCGTTGG 120 GGTTCTCCTG GCCCGGGCCT TGCCCGGCCG TGGTCCCGGC TTCGTTCCTG TCTCCGTCTC 180 GGCTCTTCTG GGGCCTTGCG CTGTCTTTGG TGGCBCCGTC CBGTGBTGGT GCGGTBCTTG 240 TCGCTGCBGC GCTCGGCCTG GTCCCGGBGB GC 272 (2) INFORMATION FOR SEQ ID NO:1740: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1740: TCGGCCTGGT CCCGG 15 (2) INFORMATION FOR SEQ ID NO:1741: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1741: TGGGGGTTTC CGTTG 15 (2) INFORMATION FOR SEQ ID NO:1742: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1742: TGGTCCCGGB GBGC 14 (2) INFORMATION FOR SEQ ID NO:1743: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 360 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1743: GCGCGGGCCG GGGGCTGCTG GGGGTTGGCC CGGGGTGCCC CGCCGCTGGG TGCCCTCGTC 60 CTCTGCGGTC GTGTCTCCTG GCTCTGGTTC CCCGCTGCGC CCGTTGTCCT CTGGGGTGGC 120 CTTCGCTCCC GGGTCTGGTT CTTGTGTTGG GGGTCCCTTT TTGGGCCTGT TGTGGCGTGG 180 CTTGTGTGTT CGGTTTCTGC CCTGTCCTCC GGCGTCCCCG GBGCCTCCCC GGGGCBGGBT 240 GBCTTTTGBG GGGGBCBCBG BTGTCTGGGC BTTGCCBGGT CCTGGGBBCB GBGCCCCGBG 300 CBGGBCCBGG BGTGCGGGCB GCGCGGGCCG GGGGCTGCTG GGBGCCBTBO- CGBGGCTGBG 360 (2) INFORMATION FOR SEQ ID NO:1744: Bi) SEQUENCE CHARACTERISTICS: (A) LENGTH: 13 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single WO 00/09525 PCT/US99/17712 cri-Iv- 482 (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1744: GGGGGCTGCT GGG 13 (2) INFORMATION FOR SEQ ID NO:1745: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 16 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1745: TGTCCTCCGG CGTCCC 16 (2) INFORMATION FOR SEQ ID NO:1746: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 17 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1746: GCCBTBGCGB GGCTGBG 17 (2) INFORMATION FOR SEQ ID NO:1747: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 16 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1747: CTCTGGGGTG GCCTTC 16 (2) INFORMATION FOR SEQ ID NO:1748: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 242 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1748: CCTCTTTTCT GTTTTTCCCC TCTGCCTTTG TTTGGGTTCG CTTCCTTTCT GCTTCTTCCC 60 TGTGTCTCCT GTCTCCGCTT TTTTCTTCGT CTTTGTTGTT TTCTCTTCCT TGCTGBGCBB 120 GBTBTCTBGB TTCTGGGGTG GTCTCGBTTT TBBBBGCTTG BGBBGCTGCB BBCBTTBTCC 180 BBBGTBTBTT TGBGGCTCCB BGGBTCBCGB CCBTCTTCCC BGGCBTTTTB BGTTGCTGTC 240 GT 242 (2) INFORMATION FOR SEQ ID NO:1749: (i) SEQUENCE CHARACTERISTICS (A) LENGTH: 7 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1749: CTGTCGT 7 (2) INFORMATION FOR SEQ ID NO:1750: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 10 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1750: TGCTTCTTCC 10 (2) INFORMATION FOR SEQ ID NO:1751: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 249 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1751: BBGTGBGBGC TGBGBGBBBC TGTGBBGCBB TCBTGBCTTC BBGBGTTCTT TTCBCCCGTT 60 CTTGGCTTCT TCTGTCCGTT GGCTTCTCGT TGTCCCTGTG GGCTTCTCGT TGTCCCCCCT 120 TCGGGGGCTG GTGGGGCCGT CCTTGCCTGC TGGGTTCTTG GCTTCTTCTG TCCGTTGGCT 180 TCTCGTTGTC CCTGTGGGCT TCTCGTTGTC CCCCCTTCGG GGGCTGGTGG GGCCGTCCTT 240 GCCTGCTGG 249 WO 00/09525 PCT/US99/17712 EPI-109 483 (2) INFORMATION FOR SEQ ID NO:1752: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 13 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1752: CCTTGCCTGC TGG 13 (2) INFORMATION FOR SEQ ID NO:1753: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 8 base pairs (H) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1753: GTTGTCCC (2) INFORMATION FOR SEQ ID NO:1754: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 77 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1754: TTTTCTCTTT CGCTTTCTTT TCGTCTCCTG TTCCTCCTTT TTTGCTGTTT TTTCTCCTTC 60 TTCTCTCCTT TCTTTTC 77 (2) INFORMATION FOR SEQ ID NO:1755: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 12 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1755: TCCTTTCTTT TC 12 (2) INFORMATION FOR SEQ ID NO:1756: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 8 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1756: CTCCTTTT 8 (2) INFORMATION FOR SEQ ID NO:1757: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 77 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1757: TTTTCTCTTT CGCTTTCTTT TCGTCTCCTG TTCCTCCTTT TTTGCTGTTT TTTCTCCTTC 60 TTCTCTCCTT TCTTTTC 77 (2) INFORMATION FOR SEQ ID NO:1758: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 11 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1758: CCTTTCTTTT C (2) INFORMATION FOR SEQ ID NO:1759: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1759: CTGTTCCTCC TTTT 14 (2) INFORMATION FOR SEQ ID NO:1760: WO 00/09525 PCT/US99/17712 EPI-109 4g4 (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 126 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1760: CTCTGTCTTG TTCTGGTCCT TCGTGGGGCT CTGTGTCGCG TGGGTGCGGC CGTGGCCGGC 60 GGBCCBGGBG TTGGBGCBGG BGCBGGBCGG GCBGGCGGCT CBTGTTTGGB TCGGCBGGBG 120 GCBCTC 126 (2) INFORMATION FOR SEQ ID NO:1761: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 10 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1761: GGBGGCBCTC 10 (2) INFORMATION FOR SEQ ID NO:1762: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 11 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1762: GTGGGGCTCT G 11 (2) INFORMATION FOR SEQ ID NO:1763: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 648 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1763: TCTGGGGTGT CCTGGCCTTC GTGGTTCCTC TTCCTTCGTT TGCCGTCCGC GGGGGCCCCC 60 GGGCCTGGCT GCGCTCCTGC CCCGCCTCTT TCCCGGGCTC TTGCGCTGGG GGGTGCTCCC 120 GTGTGTTTGC GCCCTCCTCC TGGTCGCGCT TGTCGTTTTG GGGCCGGCTT TGCCCGCCTC 180 CCGGCGCCTG GCCCGGCCTT CCTGGGCTGC GTGCGCGTTC TGTTCTTCTT CCTGGCTCTG 240 GGGTGTCCTG GCCTTCGTGG TTCCTCTTCC TTCGTTTGCC GTCCGCGGGG GCCCCCGGGC 300 CTGGCTGCGC TCCTGCCCCG CCTCTTTCCC GGGCTCTTGC GCTGGGGGGT GCTCCCGTGT 360 GTTTGCGCCC TCCTCCTGGT CGCGCTTGTC GTTTTGGGGC CGGCTTTGCC CGCCTCCCGG 420 CGCCTGGCCC GGCCTTCCTG GGCTGCGTGC GCGTTCTGTT CTTCTTCCTG GCGCAGGAGA 480 CAGGGCAGGG CGATCAGGAG CAGCGTGAGC CAAAGGAGGA CCATCGGGAA CGCAGCTCCG 540 GAACGCAGGA CAGAGGTGCC GCBGGBGBCB GGGCBGGGCG BTCBGGBGCB GCGTGBGCCB 600 BBGGBGGBCC BTCGGGBBCG CBGCTCCGGB BCGCBGGBCB GBGGTGCC 648 (2) INFORMATION FOR SEQ ID NO:1764: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 8 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1764: GBGGTGCC 8 (2) INFORMATION FOR SEQ ID NO:1765: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 7 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1765: GCCCCGC 7 (2) INFORMATION FOR SEQ ID NO:1766: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 88 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1766: CTCTGGTTGG CTTCCTTCGC CGGCBCBTGC TBGCBGGBBG BBCBGBGGGG GBBGCBGTTG 60 GGBGGTGBGB CCCBTTBBTB GGTGTCGB 88 WO 00/09525 PCT/US99/17712 EPI-109 485 (2) INFORMATION FOR SEQ ID NO:1767: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 9 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1767: GCCGGCBCB 9 (2) INFORMATION FOR SEQ ID NO:1768: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 7 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1768: TTCCTTC 7 (2) INFORMATION FOR SEQ ID NO:1769: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 562 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1769: TCTGCCCTGT CCGCCGGCTC TTCGGTGGCT CGGCCCCGCT CCTTGTCTTG CCGCGGGTTG 60 GTTCCTGGGC CTGGTTCTTG CGGGCGTTTC GGTCTGCTGG CTGGTCTGGG CCCGCGGTGC 120 GGCGGGTGGC TTGCTGTTCT GCCTGGGCTC TCCCCTCTCC TCCTTTTCTC CCTTCCTCTC 180 TCTTGCCTCC TTCCTCTGGG TCCTCTTGGC CTGGGCGCTC TTCCCCTCGG GCGGCTGCGG 240 GCGCTCGTGC TGCCTGGTCC GCTCCCTGGG GGTGCTCCTT CCCTTTCCCC GCTCGTGGGG 300 TTTGCGGGGC TGGGCTGCCC TGGGGGGTCT GGGCCTTTTG GGGTCGGCTG GCTGCTGCTT 360 CGGGCCGCCT GGGCTTCCCT GTGCCCCTTT CCTCTGCTGG GTCCCCCTCC CGTTCCAAGC 420 TGCACCGCAC AGACCGGCGC TACAGGACAG AGCCAGGCAA GCACCCATGG GGATCCAGGC 480 CCAGCTGTTC CBBGCTGCBC CGCBCBGBCC GGCGCTBCBG GBCBGBGCCB GGCBBGCBCC 540 CBTGGGGBTC CBGGCCCBGC TG 562 (2) INFORMATION FOR SEQ ID NO:1770: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 7 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1770: TCTGCGC 7 (2) INFORMATION FOR SEQ ID NO:1771: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 13 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1771: CCTGCTCCTG GGG 13 (2) INFORMATION FOR SEQ ID NO:1772: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 257 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1772: TCCCTGTTTC CCCCCTTTCG TTCTGCGTTT GCCTTTGGCG TTTTTTGTTT GTTTTCTCTC 60 TCCGTCTTTC TTCTCCCCTG TGGGBBTTTC TGTGGGGBTG GCBTBCBCGT BGGCBGCTCC 120 BBGBGCTBGC BBBCTCBBBT GCBGBBGCBT CCTCBTGGCT CTGBBBCGGT GGGAATTTCT 180 GTGGGGBTGG CATACACGTA GGCAGCTCCA AGAGCTAGCA AACTCAAATG CAGAAGCATC 240 CTCATGGCTC TGAAACG 257 (2) INFORMATION FOR SEQ ID NO: 1773: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 8 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1773: GCCCCGGG 8 WO 00/09525 PCTIUS99/17712 EPI-109 486 (2) INFORMATION FOR SEQ ID NO:1774: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 8 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear* (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1774: GGGTTTCT 8 (2) INFORMATION FOR SEQ ID NO:1775: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 11 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1775: GTGGGGBTGG C 11 (2) INFORMATION FOR SEQ ID NO:1776: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 12 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1776: CCBBGBGCTB GC 12 (2) INFORMATION FOR SEQ ID NO:1777: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 89 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1777: GTGGGAATTT CTGTGGGGBT GGCATACACG TAGGCAGCTC CAAGAGCTAG CAAACTCAAA 60 TGCAGAAGCA TCCTCATGGC TCTGAAACG 89 (2) INFORMATION FOR SEQ ID NO:1778: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 249 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1778: CTCAGTGGCC CCCAAAAGGA TGAGTAATAC ATGCGCCACG ATGATCATAT CCTTTTTACT 60 ATGAGGCCGT GTCTGTCGTG TCTTTCCTTT GCTCTTGGTG TCTCTTTGCT GTGCCCTGCC 120 TCTCTGCCCG TGTCTGTCGT GTCTTTCCTT TGCTCTTGGT GTGTCTTTGC TGTGCCCTGC 180 CTCTCTGCCC GTGTCTGTCG TGTCTTTCCT TTGCTCTTGG TGTGTCTTTG CTGTGCCCTC 240 CCTCTCTGC 249 (2) INFORMATION FOR SEQ ID NO:1779: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 7 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1779: CCGTGTC 7 (2) INFORMATION FOR SEQ ID NO:1780: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 8 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1780: GCCCTGCC 8 (2) INFORMATION FOR SEQ ID NO:1781: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 66 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear WO 00/09525 PCT/US99/17712 487 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1781: CTCBGTGGCC CCCBBBBGGB TGBGTBBTBC BTGCGCCBCG BTGBTCBTBT CCTTTTTBCT 60 BTGBGG 66 (2) INFORMATION FOR SEQ ID NO:1782: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 869 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1782: GGGGGTGGCT TCCTGCCGCG TCTCTGGGCC GTCCCGTCCC TCGGCCCCGC GCCGCGCTCG 60 GCTCCTCTCC CTCTGGCCCG GCTCGGGGCG GGGCGGGGCG GTGGGCGGGC GGCGCTGCCC 120 TGCGCGCGGC GCTGGCCCCT GCTGGCCGTC GGCTGCGCGC TGCTGGCTGC CCTGCTGGCC 180 GCGCCGGGGC CTGTCCGCCT CTGCGGGCGC TGTCTCCTGG CTTGTCTTCC GGCTCTTCTG 240 CTGGGGTGGG GCTGGGCGGC CGGCCCGGTG CTGGGGCTCC TCGGGGGGGG GGGCTCTTCC 300 GGGCTGTCTC CCTCCGGGGC GGGGGTTTCT GGCCGTGGGG GTCTTGCCTG GCCTCCGGGC 360 TCCTGCTTGT CTTGCCTTCC TTCTCTGGTC GGTTGTGGCT CGGGGCTCCG TGGGTCCCTG 420 GCGCCCGTTT GTGTTTTGTC TTTTCCCCTG GCGTCCCTGT GCCCCTCTCC TCTCCTTCCT 480 CTGCTTCTCG CTCTCCTTTG TGGGGCCCTC CCTGCTGCTC TTGGTTTTGG GCTTTTTTTC 540 TCTTCCTCCT TTTTCGTGCG TGGGCCTCCG CACGCCTCTT GCCACCTCCT GCGCAGGGCA 600 GCGCCTTGGG GCCAGCGCCG CTCCCGGCGC GGCCAGCAGG GCAGCCAGCA GCGCGCAGCC 660 GACGGCCAGC ATGCTTCCTC CTCGGCTACC ACTCCATGGT CCCGCAGAGG CGGACAGGCG 720 CBCGCCTCTT GCCBCCTCCT GCGCBGGGCB GCGCCTTGGG GCCBGCGCCG CTCCCGGCGC 780 GGCCBGCBGG GCBGCCBGCB GCGCGCBGCC GBCGGCCBGC BTGCTTCCTC CTCGGCTBCC 840 BCTCCBTGGT CCCGCBGBGG CGGBCBGGC 869 (2) INFORMATION FOR SEQ ID NO:1783: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 13 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1783: GCBGCCBGCB GCG 13 (2) INFORMATION FOR SEQ ID NO:1784: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1784: CGCBGCCGBC GGCC 14 (2) INFORMATION FOR SEQ ID NO:1785: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 869 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1785: GGGGGTGGCT TCCTGCCGCG TCTCTGGGCC GTCCCGTCCC TCGGCCCCGC GCCGCGCTCG 60 GCTCCTCTCC CTCTGGCCCG GCTCGGGGCG GGGCGGGGCG GTGGGCGGGC GGCGCTGCCC 120 TGCGCGCGGC GCTGGCCCCT GCTGGCCGTC GGCTGCGCGC TGCTGGCTGC CCTGCTGGCC 180 GCGCCGGGGC CTGTCCGCCT CTGCGGGCGC TGTCTCCTGG CTTGTCTTCC GGCTCTTCTG 240 CTGGGGTGGG GCTGGGCGGC CGGCCCGGTG CTGGGGCTCC TCGGGGGGGG GGGCTCTTCC 300 GGGCTGTCTC CCTCCGGGGC GGGGGTTTCT GGCCGTGGGG GTCTTGCCTG GCCTCCGGGC 360 TCCTGCTTGT CTTGCCTTCC TTCTCTGGTC GGTTGTGGCT CGGGGCTCCG TGGGTCCCTG 420 GCGCCCGTTT GTGTTTTGTC TTTTCCCCTG GCGTCCCTGT GCCCCTCTCC TCTCCTTCCT 480 CTGCTTCTCG CTCTCCTTTG TGGGGCCCTC CCTGCTGCTC TTGGTTTTGG GCTTTTTTTC 540 TCTTCCTCCT TTTTCGTGCG TGGGCCTCCG CACGCCTCTT GCCACCTCCT GCGCAGGGCA 600 GCGCCTTGGG GCCAGCGCCG CTCCCGGCGC GGCCAGCAGG GCAGCCAOCA GCGCGCAGCC 660 GACGGCCAGC ATGCTTCCTC CTCGGCTACC ACTCCATGGT CCCGCAGAGG CGGACAGGCG 720 CBCGCCTCTT GCCBCCTCCT GCGCBGGGCB GCGCCTTGGG GCCBGCGCCG CTCCCGGCGC 780 GGCCBGCBGG GCBGCCBGCB GCGCGCBGCC GBCGGCCBGC BTGCTTCCTC CTCGGCTBCC 840 BCTCCBTGGT CCCGCBGBGG CGGBCBGGC 869 (2) INFORMATION FOR SEQ ID NO:1786: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 8 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1786: WO 00/09525 PCT/US99/17742 488 GGGGCBGG 8 (2) INFORMATION FOR SEQ ID NO:1787: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 13 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1787: GBBGGCBGCB GGC 13 (2) INFORMATION FOR SEQ ID NO:1788: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1788: CCBGGBGCBG CCCC 14 (2) INFORMATION FOR SEQ ID NO:1789: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1789: BGGGBGBBGG CBBC 14 (2) INFORMATION FOR SEQ ID NO:1790: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 128 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1790: CTCCTGGGGG TBCTGGGGCB GGGBBGGCBG CBGGCBBCBC CBGGBGCBGC CCCBGGGBGB 60 BGGCBBCTGG BCCGBBGGCG CTTGTGGBGB BGGBGTTCBT BGCTGGGCTC CTGGBGGGGB 120 GBTBGBGC 128 (2) INFORMATION FOR SEQ ID NO:1791: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 244 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1791: GGGGTGGBBB GGTTTGGBGT BTGTCTTTBT GCBCTGBCBT CTBBGTTCTT TBGCBCTCCT 60 TGGCBBBBCT GCBCCTTCBC BCBGBGCTGC BGBBBTCBGG BBGGCTGCCB BGBGBGCCBC 120 GGCCBGCTTG GBBGTCBTGT TTBCBCBCBG TGBGBTGGTT CCTTCCGGGC TTGTGTGCTC 180 TGCTGTCTCT TGGTTCCTTC CGGTGGTTTC TTCCTGGCTC TTGTCCTTTC TCTTGGCCCT 240 TGGC 244 (2) INFORMATION FOR SEQ ID NO:1792: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 8 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1792: GGBGTBTG 8 (2) INFORMATION FOR SEQ ID NO:1793: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 12 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1793: GCBCTGBCBT CT 12 (2) INFORMATION FOR SEQ ID NO:1794: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 7 base pairs (B) TYPE: nucleic acid WO 00/09525 PCT/US99/17712 489 (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1794: CCGGTGG 7 (2) INFORMATION FOR SEQ ID NO:1795: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 10 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1795: GGCCCTTGGC 10 (2) INFORMATION FOR SEQ ID NO:1796: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 87 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1796: GGGGTGGBBB GGTTTGGBGT BTGTCTTTBT GCBCTGBCBT CTBBGTTCTT TBGCBCTCCT 60 TGGCBBBBCT GCBCCTTCBC BCBGBGC 87 (2) INFORMATION FOR SEQ ID NO:1797: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 489 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1797: GGGCTCCCGC CGCGBGBGGT TBTGGGCTCC CBGGBCCBCC CGCBCCGCGC GGBCGTTTBC 60 BTTCGCCBCG CBGTGCGCGG CCGBCBTGBC GBBGTTGGGC GCBBTCBGGG TGGCGCCGCB 120 GBBGTGGCCT CCGCGCBGCT GCBGGGBCBC CBTGBBGGGC CBCGCGTGGG GCCGCGCTCG 180 CCGGCCCCCC BCBBTCTCCG BGGCCBGCGC GGTGCCCCCC BGCBGCBBGG CCGGCBGGBC 240 BCBGGCGBGG BGBCBCGCGB GTCGGCGGCC GBGGGTCBTG GTGGGGCTGG GGCTCCGGGG 300 TCTCTGCCCC TCCGTGCTGG TGGGGCTGGG GCTCCGGGGT CTCTGCCCCT CCGTGCCGCG 360 TGGGGCCGCG CTCGCCGGCC CCCCCCTGCC GGGTGGGCTC CCGCCGCGCG CCGGCCTGCC 420 GGCCCCTCGT GGGTCCTGCT GGCCGGGTCC GGGTCCCGGG GGTGGGGCGC GBGTCGGCGG 480 CCGBGGGTC 489 (2) INFORMATION FOR SEQ ID NO:1798: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 8 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1798: GGTGGGGC 8 (2) INFORMATION FOR SEQ ID NO:1799: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 7 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1799: GGGGCCG 7 (2) INFORMATION FOR SEQ ID NO:1800: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 13 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1800: GGCCGGGTCC GGG 13 (2) INFORMATION FOR SEQ ID NO:1801: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 317 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: Genomic
DNA
WO 00/09525 PCT/US99/17712 EPI-109 490 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1801: GGGCTCCCGC CGCGBGBGGT TBTGGGCTCC CBGGBCCBCC CGCBCCGCGC GGBCGTTTBC 60 BTTCGCCBCG CBGTGCGCGG CCGBCBTGBC GBBGTTGGGC GCBBTCBGGG TGGCGCCGCB 120 GBBGTGGCCT CCGCGCBGCT GCBGGGBCBC CBTGBBGGGC CBCGCGTGGG GCCGCGCTCG 180 CCGGCCCCCC BCBBTCTCCG BGGCCBGCGC GGTGCCCCCC BGCBGCBBGG CCGGCBGGBC 240 BCBGGCGBGG BGBCBCGCGB GTCGGCGGCC GBGGGTCBTG GTGGGGCTGG GGCTCCGGGG 300 TCTCTGCCCC TCCGTGC 317 (2) INFORMATION FOR SEQ ID NO:1802: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 308 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: Genomic DNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1802: CGGGBGTGGG GGTCCTGGBC GGCBCTGBBG GCBTCCBGGG CTCCCTTCCB GTCCTTCTTG 60 TCCGCTGCCB GCBCCCCTTC BTTCCBGBGG CTGBTGGCCT CCBCCBGGGB CBTGBTTBGG 120 TBGBBBCTBG GBGGCCGGCC TCCBCCBGGG BCBTGGTCCT TCTTGTCCGC TGCCTCTCTG 180 GGGTTTTCGG TCTGGGTGGG CTTTCCTCCT GGGGCTGCTG CTGGGCTCTT CTTTTTGTTT 240 CTGGCCTGGT GCTCTCTCGT GCCCTTTCCC TTGGGTGTCT TGTTTTTGTG GCCTCCBCCB 300 GGGBCBTG 308 (2) INFORMATION FOR SEQ ID NO:1803: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 12 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1803: CGGGBGTGGG GG 12 (2) INFORMATION FOR SEQ ID NO:1804: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 11 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1804: GCCBGCBCCC C 11 (2) INFORMATION FOR SEQ ID NO:1805: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 7 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1805: CCBCCBG 7 (2) INFORMATION FOR SEQ ID NO:1806: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 136 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1806: CGGGBGTGGG GGTCCTGGBC GGCBCTGBBG GCBTCCBGGG CTCCCTTCCB GTCCTTCTTG 60 TCCGCTGCCB GCBCCCCTTC BTTCCBGBGG CTGBTGGCCT CCBCCBGGGB CBTGBTTBGG 120 TBGBBBCTBG GBGGCC 136 (2) INFORMATION FOR SEQ ID NO:1807: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 233 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1807: CCCTCCBCBT CTGCTCTGBC CTGCTGGBCT CTGGBTCTGB BGBTBCGCCB TGTBGGGGCG 60 GGBGTGGGGC CTGCTCTCCC GGCCTCCGBT GBTCTCCCCT GCCTCBGCCC CBGTGGGTBG 120 GBGBBBGGCC BGCBGBBGCB GGBGTGGCTG CBTCTTTCCT GGTGGGGCCT GCTCTCCCGG 180 CCTCCGTGTG TTGCTGGGTG TTTTCCCGTC TCTGGTCTGC CTTCGGGGGT CGT 233 (2) INFORMATION FOR SEQ ID NO:1808: (i) SEQUENCE CHARACTERISTICS: WO 00/09525 PCT/US99/17712 491 (A) LENGTH: 11 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1808: GBBGBTBCGC C (2) INFORMATION FOR SEQ ID NO:1809: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 9 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1809: CBGCCCCBG 9 (2) INFORMATION FOR SEQ ID NO:1810: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 12 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1810: TCCCGTCTCT GG 12 (2) INFORMATION FOR SEQ ID NO:1811: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 150 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1811: CCCTCCBCBT CTGCTCTGBC CTGCTGGBCT CTGGBTCTGB BGBTBCGCCB TGTBGGGGCG 60 GGBGTGGGGC CTGCTCTCCC GGCCTCCGBT GBTCTCCCCT GCCTCBGCCC CBGTGGGTBG 120 GBGBBBGGCC BGCBGBBGCB GGBGTGGCTG 150 (2) INFORMATION FOR SEQ ID NO:1812: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 222 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1812: CCGGGGCTGC BGCBBCCTCB TCBGCTCTTG CCTGGBGTGG CTCBGCCTGG GCCTGCBGGG 60 CCBCCBGGBG BBTGGCBGCB BGGBTGGCGB GGGTCCTCBT GGCTGGGGTC BCBGBTCCTC 120 TBGCTBGGCB GGGTGBCCBG BGBGGGCGGG TCCTCBTGGC TGGGGGCCTG GGCCTGCBGG 180 GCCGCTCTTG CCTGGBGTGG CTCGCCCBGB GTCTTCCCTG GT 222 (2) INFORMATION FOR SEQ ID NO:1813: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 7 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1813: CCGGGGC 7 (2) INFORMATION FOR SEQ ID NO:1814: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1814: GGGCCTGCBG GGCC 14 (2) INFORMATION FOR SEQ ID NO:1815: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 10 base pairs (H) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1815: GGCBGCBBGG 10 WO 00/09525 PCTIUS99/17712 EPI-109 492 (2) INFORMATION FOR SEQ ID NO:1816: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 147 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1816: CCGGGGCTGC BGCBBCCTCB TCBGCTCTTG CCTGGBGTGG CTCBGCCTGG GCCTGCBGGG 60 CCBCCBGGBG BBTGGCBGCB BGGBTGGCGB GGGTCCTCBT GGCTGGGGTC BCBGBTCCTC 120 TBGCTBGGCB GGGTGBCCBG BGBGGGC 147 (2) INFORMATION FOR SEQ ID NO:1817: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 180 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1817: CGCTGCBBTC TGCTCCGGGG CTGCBGCBBC CTCBTCBGCT CTTGCCTGGB GTGGCTCBGC 60 CTGGGCCTGC BGGGCCBCCB GGBGBBTGGC BGCBBGGBTG GCGBGGGTCC TCBTGGCTGG 120 GGTCBCCTGG BGGBGGGBGB GCBGGGGGTC CTCBTGGCTG GGGTCCCTCT CTCCCGTCCT 180 (2) INFORMATION FOR SEQ ID NO:1818: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 10 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1818: GGCBGCBBGG 10 (2) INFORMATION FOR SEQ ID NO:1819: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 8 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1819: GGCTGGGG 8 (2) INFORMATION FOR SEQ ID NO:1820: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 9 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1820: GGGGTCBCC 9 (2) INFORMATION FOR SEQ ID NO:1821: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 145 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1821: CGCTGCBBTC TGCTCCGGGG CTGCBGCBBC CTCBTCBGCT CTTGCCTGGB GTGGCTCBGC 60 CTGGGCCTGC BGGGCCBCCB GGBGBBTGGC BGCBBGGBTG GCGBGGGTCC TCBTGGCTGG 120 GGTCBCCTGG BGGBGGGBGB GCBGG 145 (2) INFORMATION FOR SEQ ID NO:1822: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 374 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single .(D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1822: GTCTTTGTTT CTGGGCTCGT GCCCCBTCCC GGCTTCTCTC TGGTTCCGTC CTCTGTGGTG 60 TTTGGCCCTG CTTCCTTTTG CCTGTTGAGG GGGCAGCAGT TGGGCCCCAA AGGCCCTCTC 120 GTTCACCTTC TGGCACGGAG TTGCATCCCC ATAGTCAAAC TCTGTGGTCG TGTCATAGTC 180 CTCTGTGGTG TTTGGAGTTT CCATCCCGGC TTCTCTCTGG TTCCAAGGGA GBGGGGGCBG 240 CBGTTGGGCC CCBBBGGCCC TCTCGTTCBC CTTCTGGCBC GGBGTTGCBT CCCCBTBGTC 300 BBBCTCTGTG GTCGTGTCBT BGTCCTCTGT GGTGTTTGGB GTTTCCBTCC CGGCTTCTCT 360 CTGGTTCCBB GGGB 374 WO 00/09525 PCT/US99/17712 493 (2) INFORMATION FOR SEQ ID NO:1823: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 7 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1823: GGGCCCC 7 (2) INFORMATION FOR SEQ ID NO:1824: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 9 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1824: GGGGGCBGC 9 (2) INFORMATION FOR SEQ ID NO:1825: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 9 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1825: CCCGGCTTC 9 (2) INFORMATION FOR SEQ ID NO:1826: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 303 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1826: GGGCBCGGGG CBGTGGGCGG GCBBTGTBGG CBBBGCBGCB GGGTGTGGTG TCCGBGGBBT 60 BTGGGGBGGC BGBTGCBGGB GCGCBGBGGG CBGTBGCBBT GBGGBTGBCB GCGBGGCGTG 120 CCGCGGBGBC CTTCBTGGTB CCTGTGGBGB GGCTGTCGGB GGGGGTGTGG TGTCCGCTTG 180 GCGGTTCTTT CGGGTGTTTC TTCTCTGGGT TGGCCTGCTG CTCGTCGTGG TCGCTCCGCT 240 CCCGGGTTCG TCTCGCTCTG TCGCCCCTTC CTTCCTTGTC GTGTTCCTCC CTTCCTTGCC 300 TCT 303 (2) INFORMATION FOR SEQ ID NO:1827: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 8 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1827: GGGTTGGC 8 (2) INFORMATION FOR SEQ ID NO:1828: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 8 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1828: CGGGGCBG 8 (2) INFORMATION FOR SEQ ID NO:1829: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 10 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1829: CCCGGGTTCG 10 (2) INFORMATION FOR SEQ ID NO:1830: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 10 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1830: WO 00/09525 PCT/US99/17712 494 GGGTGTGGTG 10 (2) INFORMATION FOR SEQ ID NO: 1831: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 162 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1831: GGGCBCGGGG CBGTGGGCGG GCBBTGTBGG CBBBGCBGCB GGGTGTGGTG TCCGBGGBBT 60 BTGGGGBGGC BGBTGCBGGB GCGCBGBGGG CBGTBGCBBT GBGGBTGBCB GCGBGGCGTG 120 CCGCGGBGBC CTTCBTGGTB CCTGTGGBGB GGCTGTCGGB GG 162 (2) INFORMATION FOR SEQ ID NO:1832: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 213 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1832: GCTGCCCGGC GGGGTGTGCG CTTGGCGCTC CCGTGCTCGG TTCTCTGTCT CCCGGTCCCC 60 CTTGCCTGGC GTCTCGGGCC TTCGTCCTCT TCCTCTTCTT CCTTCCGCTC CGTGGGGGCT 120 GCTTGGTGGG GGCCTGTGCC TCGGGGTCCC GGGGCTTCTG GCCCTTGCCG TTCATGGTGG 180 CTAGGTGGGG CGTTCBTGGT GGCTBGGTGG GGC 213 (2) INFORMATION FOR SEQ ID NO:1833: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 8 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1833: GGTGGGGC 8 (2) INFORMATION FOR SEQ ID NO: 1834: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 11 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1834: GCCCGGCGGG G 11 (2) INFORMATION FOR SEQ ID NO:1835: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1835: CGGGGCTTCT GGCCC 15 (2) INFORMATION FOR SEQ ID NO:1836: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 347 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1836: GGGGTGGGTB GGCCGTGTCT GGGGGTTGGC CBTGTTGGTT GCCTCTTGGT GGTGCGCCGG 60 GCGCGTCTTG GCTTTCTTCT CCTTCGGGCC CTCGGGCCGG TGCTTGTGGG CTCCTCCCGG 120 GCGGCCTCCC CGGGCGGGGG CTTCTTGGCG CTGGCGGGGG GGCCTCCTGC TCTGTGGCTG 180 GGCGTTCCTT GGTGTTCTGG GTGGTGGCGG GCGTGGTGGC CTCTGTGGGG GCCCGCGGCT 240 GCBGGGGTTG CCTGTCTGCT TCGTCCTTTG CGCTCCCGGG CCGCCGGGGT GGGTAGGCCG 300 TGTCTGGGGG TTGGCCATGT TGGTTGCCGG GCCCGCGGCT GCAGGGG 347 (2) INFORMATION FOR SEQ ID NO:1837: Ci) SEQUENCE CHARACTERISTICS: (A) LENGTH: 9 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1837: CCCGGGCGG 9 WO 00/09525 PCTIUS99/17712 EPI-109 495 (2) INFORMATION FOR SEQ ID NO:1838: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 12 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1838: GGCGGGGGGG CC 12 (2) INFORMATION FOR SEQ ID NO:1839: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 11 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1839: CCCGGGCCGC C 11 (2) INFORMATION FOR SEQ ID NO:1840: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 8 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1840: GGCCGTGT 8 (2) INFORMATION FOR SEQ ID NO:1841: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 664 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1841: CGGTTTCCTT TGCGGTCTTG GCCCGGGCTC CGGGTGCCCG CCCGCCCGCC GGCCGCCGCC 60 CCGCCGGGCT GTCCCCGCCC CGCCCCGGCC CGGGGCGCGG GGGCGGCCCT CCCGCCCCTC 120 TGGGCCGGCG CGGGCGTCGG CCGCTCGCGC CTGGGGTTCC CTCTCCTCCC CCTGTGCGCC 180 TGCCTCTTGC TCTTCTGCGT CCGCTGCCTT CTCCCCTCTC CTCGGCCGTT GCCTGTGCTG 240 TCCGTCCTGT CGCCCTTCCG TGGTGCTGTT GTCTCTTCTG CCCTCGGTGT GCTGGTGCTG 300 GTGGTGGTGC CTCTGCCCGT GCTCGCCCTG CCTGGGCTGG CCTCTTCGGG TGTGGCTTTG 360 GGGCTCTCTT GGTTGCCCTT TCTTCTCGTG GTGCCTCTCC TCCCTGGCTT GGTCGTTGTC 420 TGGGGTGGTG CTCCTCTCCC TTTCCCTGCT GGCCGTTTGT CCTGTTTTCT GTCTTCCTCT 480 TTCCTCCTGT TTCTCCGTTT GGCTTGCTGC TTGCGGGGCT GTCTCCCTTG CCCCTGTGGG 540 CTTTCCCTGG TCCGGTCTTC TCCTTGGGGG TCGCCCTTCT TGGTGGGCTG GCTCGTCTGT 600 CTTTTTCCTT CCTGGGGGTG GCCGTTGTGG GCGGTGTGGT CCGCCTTGCC TCTGCTGGTC 660 TTTC 664 (2) INFORMATION FOR SEQ ID NO:1842: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 9 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1842: GGCCCGGGC 9 (2) INFORMATION FOR SEQ ID NO:1843: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 13 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1843: GCCGGCGCGG GCG 13 (2) INFORMATION FOR SEQ ID NO:1844: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 13 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1844: GCCTGGGCTG GCC 13 (2) INFORMATION FOR SEQ ID NO:1845: WO 00/09525 PCT/US99/17712 EPI-109 496 (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 11 base pairs (H) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1845: GGGGGTGGCC G 11 (2) INFORMATION FOR SEQ ID NO:1846: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 21 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1846: GGGGGTGGCC GTTGTGGGCG G 21 (2) INFORMATION FOR SEQ ID NO:1847: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 266 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1847: GBTGTTTGTT BCCBBBGCBT CBBGBBTBGC TTTGCTBTCT BBGGBTCBCB TTTBGBCBTB 60 GGBBBBCGCT GTBGGTCBGB BBGBTGTGCT TBCCTTCBCB CBGBGCTGCB GBBBTCBGGB 120 BGGCTGCCBB GBGBGCCBCG GCCBGCTTGG BGTCBTGTTT BCBCBCBGTG BGGTGCTCCG 180 GTGGCTTTTT GCTTGTGTGC TCTGCTGTCT CTGTTCCTTC CGGTGGTTTC TTCCTGGCTC 240 TTGTCCTTTC TCTTGGCCCT TGGCCC 266 (2) INFORMATION FOR SEQ ID NO:1848: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 7 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1848: GCTCCGG 7 (2) INFORMATION FOR SEQ ID NO:1849: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 10 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1849: CBBGBBTBGC 10 (2) INFORMATION FOR SEQ ID NO:1850: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1850: CBCBCBGTGB GGTGC 15 (2) INFORMATION FOR SEQ ID NO:1851: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 20 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1851: BCCBBBGCBT CBBGBBTBGC 20 (2) INFORMATION FOR SEQ ID NO:1852: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 21 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear Cxi) SEQUENCE DESCRIPTION: SEQ ID NO:1852: GCCBBGBGBG CCBCGGCCBG C 21 WO 00/09525 PCT/US99/17712 497 (2) INFORMATION FOR SEQ ID NO:1853: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 196 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1853: GBTGTTTGTT BCCBBBGCBT CBBGBBTBGC TTTGCTBTCT BBGGBTCBCB TTTBGBCBTB 60 GGBBBBCGCT GTBGGTCBGB BBGBTGTGCT TBCCTTCBCB CBGBGCTGCB GBBBTCBGGB 120 BGGCTGCCBB GBGBGCCBCG GCCBGCTTGG BGTCBTGTTT BCBCBCBGTG BGGTGCTCCG 180 GTGGCTTTTT GCTTGT 196 (2) INFORMATION FOR SEQ ID NO:1854: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 400 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1854: ACAGGGGCTG TAATCTTCAT CTGCAGGTGG CATGCCAGTG AAATTTAGAT CATCAAAATC 60 CCACATCTGT GGATCTGTAA TATTTGACAT GTCCTCTTCA GTTTCAGCAA TGGTTTGATC 120 TAACTGAAGC ACCGGCCAGG BCBGGGGCTG TBBTCTTCBT CTGCBGGTGG CBTGCCBGTG 180 BBBTTTBGBT CBTCBBBBTC CCBCBTCTGT GGBTCTGTBB TBTTTGBCBT GTCCTCTTCB 240 GTTTCBGCBB TGGTTTGBTC TBBCTGBBGC BCCGGCCBGG TGGCTCGGTG CTTCTGCCCC 300 TGTTGTTGCG GCGCTCGGTT GGTGTGGCCC CTGTGGTGCT TCGTTTCCCC CTCTTTCTCT 360 TTGTTCGGGG GTTCTTGTGG CGGGCTGCTT GTCTCGTTCC 400 (2) INFORMATION FOR SEQ ID NO:1855: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 7 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1855: CBGGGGC 7 (2) INFORMATION FOR SEQ ID NO:1856: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 9 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1856: GCBGGTGGC 9 (2) INFORMATION FOR SEQ ID NO:1857: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 9 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1857: GCGGCGCTC 9 (2) INFORMATION FOR SEQ ID NO:1858: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 140 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1858: ACAGGGGCTG TAATCTTCAT CTGCAGGTGG CATGCCAGTG AAATTTAGAT CATCAAAATC 60 CCACATCTGT GGATCTGTAA TATTTGACAT GTCCTCTTCA GTTTCAGCAA TGGTTTGATC 120 TAACTGAAGC ACCGGCCAGG 140 (2) INFORMATION FOR SEQ ID NO:1859: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 140 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1859: BCBGGGGCTG TBBTCTTCBT CTGCBGGTGG C9TGCCBGTG BBBTTTBGBT CHTCBBBBTC 60 CCBCBTCTGT GGBTCTGTBB TBTTTGBCBT GTCCTCTTCB GTTTCBGCBB TGGTTTGBTC 120 WO 00/09525 PCT/US99/17712 EPI-109 498 TBBCTGBBGC BCCGGCCBGG 140 (2) INFORMATION FOR SEQ ID NO:1860: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 346 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1860: CTTGBGCBGG BBGCTCTGGG GCBGGGBGCT GGCBGGGCCC BGGGGGGTGG CTTCCTGCBC 60 TGTCCBGBGT GCBCTGTGCC BCBGCBGCBG CTGCBGGGCC BTCBGCTTCB TGGGGCTCTG 120 GGTGGCBGGT CCBGCCBTGG GTCTGGGTGG GGCTGGGCTG CBGGCTCCGG GCGGTCCBGC 180 CBTGGGTCTG GGGGCTGGGC TGCBGGCTCC GGGCGGGCGG GTGCGGGCTG CGTGCTGGGG 240 GCTGCCCCGC AGGCCCTGCG GTCCBGCCBT GGGTCTGGGG GCTGGGCTGC HGGCTCCGGG 300 CGGGCGGGTG CGGGCTGCGT GCTGGGGGCT GCCCCGCAGG CCCTGC 346 (2) INFORMATION FOR SEQ ID NO:1861: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 10 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1861: GBGCBGGBBG 10 (2) INFORMATION FOR SEQ ID NO:1862: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1862: GCCBCBGCBG CBGC 14 (2) INFORMATION FOR SEQ ID NO:1863: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 10 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1863: GGGTGCGGGC 10 (2) INFORMATION FOR SEQ ID NO:1864: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 172 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1864: CTTGBGCBGG BBGCTCTGGG GCBGGGBGCT GGCBGGGCCC BGGGGGGTGG CTTCCTGCBC 60 TGTCCBGBGT GCBCTGTGCC BCBGCBGCBG CTGCBGGGCC BTCBGCTTCB TGGGGCTCTG 120 GGTGGCBGGT CCBGCCBTGG GTCTGGGTGG GGCTGGGCTG CBGGCTCCGG GC 172 (2) INFORMATION FOR SEQ ID NO:1865: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 818 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1865: GCBCCGCCTG GBGCCCTGGG GCCCCCCTGT CTTCTTGGGG BGCGCCTCCT CGGCCBGCTC 60 CBCGTCCCGG BTCBTGCTTT CBGTGCTCBT GGTGTCCTTT CCBGGGGBGB GBGGGGCTGG 120 TCCTCTGCTG TCCTTGCTGG TGCTCBTGGT GTCCTTTCCG CCCTGGGGCC CCCCTGTCTT 180 CTTGGGGCCT CTTCCCTCTG GGGGCCGTCT CTCTCCCTCT CTTGCGTCTC TCT-TTTCTC 240 TCTCTCTCTT CCCCTTTCCC GCTCTTTCTG TCTCGGTGTC TGGTTTTCTC TCTCCGCTGG 300 CTGCCTGTCT GGCCTGCGCT CTTGGCCTGT GCTGTTCCTC CTCCGGTTCC TGTCCTCTCT 360 GTCTGTCGCC CCCTCTGGGG TCTCCCTCTG GGTGGTGGTC TTGTTGCTTG GGCTGGGCTC 420 CGTGTCTCCB GTGCTCBTGG TGTCCGCTGB GGGBGCGTCT GCTGGCGCTG GTCCTCTGCT 480 GTCCTTGCTG GTGCTCBTGG TGTCCTTTCC GCCCTGGGGC CCCCCTGTCT TCTTGGGGCC 540 TCTTCCCTCT GGGGGCCGTC TCTCTCCCTC TCTTGCGTCT CTCTCTTTCT CTCCTCTCT 600 TCCCCTTTCC CGCTCTTTCT GTCTCGGTGT CTGGTTTTCT CTCTCCGCTG GCTGCCTGTC 660 TGGCCTGCGC TCTTGGCCTG TGCTGTTCCT CCTCCGGTTC CTGTCCTCTC TGTCTGTCGC 720 CCCCTCTGGG GTCTCCCTCT GGCGTGGTGG TCTTGTTGCT TGGGCTGGGC TCCSTGTCTC 780 CTGTGCTCBT GGTGTCCGCT GCGGGBGCGT CTGCTGGC 818 WO 00/09525 PCT/US99/17712 EPI-109 499 (2) INFORMATION FOR SEQ ID NO:1866: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 10 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1866: GGGGCCCCCC 10 (2) INFORMATION FOR SEQ ID NO:1867: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 11 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1867: GGGGGCCGTC T 11 (2) INFORMATION FOR SEQ ID NO:1868: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 20 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1868: CCBGGGGBGB GBGGGGCTGG 20 (2) INFORMATION FOR SEQ ID NO:1869: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 364 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1869: CTCGGTBGBC GCGCTCGBBC TCGGGTGGGC CGGTGGTGBG CGGCGGCGBC BCGCGGBBGG 60 CCCTGCGCGC CGBGBTCBCC TGCBGGGBGB BGTBGGCTTG CBGCBGGBCT CCCBGGBGGG 120 TGBCBGCBGC CBGTBGBGCT BCCTCGTCCT TCBTGGTBCC GTCGGTGTGG TGGCBCGGGC 180 TGTGTGTGBB GGCGBGCTGG GCCCCGTCTG CTGCTCCTCG TGCCGCCTCG TCCTTCATGG 240 TACCGTCGGT GTGGTGGCCT CGGGTGGGCC GGTGGTGGGG CGCGCGCGCT CGCGTGGCTC 300 CGGCTCTTCT TTCCCGGCTC CGTCGGCCCG GGGGCCTTGG TCTCCCTCGT CCTTCBTGGT 360 BCCG 364 (2) INFORMATION FOR SEQ ID NO:1870: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 10 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1870: GCBGCBGGBC 10 (2) INFORMATION FOR SEQ ID NO:1871: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 10 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1871: CCCGGCTCCG 10 (2) INFORMATION FOR SEQ ID NO:1872: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 13 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1872: CGGCCCGGGG GCC 13 (2) INFORMATION FOR SEQ ID NO:1873: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 7 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single WO 00/09525 PCT/US99/17712 EPI-109 500 (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1873: CBCGCGG 7 (2) INFORMATION FOR SEQ ID NO:1874: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 200 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1874: CTCGGTBGBC GCGCTCGBBC TCGGGTGGGC CGGTGGTGBG CGGCGGCGBC BCGCGGBBGG 60 CCCTGCGCGC CGBGBTCBCC TGCBGGGBGB BGTBGGCTTG CBGCBGGBCT CCCBGGBGGG 120 TGBCBGCBGC CBGTBGBGCT BCCTCGTCCT TCBTGGTBCC GTCGGTGTGG TGGCBCGGGC 180 TGTGTGTGBB GGCGBGCTGG 200 (2) INFORMATION FOR SEQ ID NO:1875: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 530 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1875: BCCGGCGGBG CCGCCBGGGT GGBCTGGGBG TGGGTTTCTC CCCGCCGTTC TCBCCCBCCG 60 CGCTGBGCTC BGCGCCTBBG BCTGCTGTTT CTGGBGCTCC TTGGCBBGCC BCBBBCBGCB 120 GBGBGBBBBT CBTGBGCBBB TBBTCCBTTC TGBBBBBBBG GGBTCBBBH CCTCCCGTTC 180 CCCGTTCGCC TGGCGCGCGC TGCGGGTTCC TCGTGGGTTT CTCCCCGCCG TTCTCCGGTC 240 TGTTGCCTTT GTGGGCTTCT TGTCTTTTTG GCTGTTCTTT TCCTGCTTGG CGTCTTTTCC 300 TTTCTTTGTG CTCGGTTGTG GGTCCGCTGG TCCTTTGCCC TGTGTGTTTC TGCTGCCCGT 360 TCGCCTGGCG CGCGCTGCGG GTTCCTCGTG GGTTTCTCCC CGCCGTTCTC CGGTCTGTTG 420 CCTTTGTGGG CTTCTTGTCT TTTTGGCTGT TCTTTTCCTG CTTGGCGTCT TTTCCTTTCT 480 TTGTGCTCGG TTGTGGGTCC GCTGGTCCTT TGCCCTGTGT GTTTCTGCTG 530 (2) INFORMATION FOR SEQ ID NO:1876: (i) SEQUENCE CHARACTERISTICS: TA) LENGTH: 23 base pairs (B) TYPE: nucleic acid TC) STRANCEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1876: CCGGCGGBGC CGCCBGGGTG GBC 23 (2) INFORMATION FOR SEQ ID NO:1877: Ci) SEQUENCE CHARACTERISTICS: CA) LENGTH: 9 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1877: CCGCCBGGG 9 (2) INFORMATION FOR SEQ ID NO:1878: (iC SEQUENCE CHARACTERISTICS: CA) LENGTH: 9 base pairs (B) TYPE: nucleic acid TCT STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1878: GGCGCGCGC 9 (2) INFORMATION FOR SEQ ID NO:1879: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 10 base pairs () TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1879: GTGGGTCCGC 10 (2) INFORMATION FOR SEQ ID NO:1880: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 399 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear WO 00/09525 PCT/US99/17712 501 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1880: GCCCTGTCGG GCGGGAAGCC TCTCTCCTCT CCCCAGATCC GCGACAGGCC GCAGGCAAGA 60 ACCAGCGCAA CCAGGGCGCG TCCGCACAGA CTTGGAGGCG GCTGCATGCT GCTACCTGCT 120 CCAGAAGCGT CCGGTGGCCG CCGCGCCCTG TCGGGCGGGB BGCCTCTCTC CTCTCCCCBG 180 BTCCGCGBCB GGCCGCBGGC BBGBBCCBC GCBBCCBGGG CGCGTCCGCB CBGBCTTGGB 240 GGCGGCTGCB TGCTGCTBCC TCCTCGGGCG GGBBGCCTCC GGTGGCCGCC GCGCGTCCGG 300 TGGCCGCCGC GCCTCTCTCC TCTCCCCGTG GCCCTGTCGG GCGGGTCCTG CCGTCCTGTC 360 TCCTTTTCTT TTGCTGTCTT GTCTTCCCGT CTCTGCTTT 399 (2) INFORMATION FOR SEQ ID NO:1881: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 13 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (0) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1881: CGGGCGGGBB GCC 13 (2) INFORMATION FOR SEQ ID NO:1882: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 8 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (0) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1882: CGGGCGGG 8 (2) INFORMATION FOR SEQ ID NO:1883: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 10 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (0) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1883: CCGCBCBGBC 10 (2) INFORMATION FOR SEQ ID NO:1884: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 144 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1884: GCCCTGTCGG GCGGGAAGCC TCTCTCCTCT CCCCAGATCC GCGACAGGCC GCAGGCAAGA 60 ACCAGCGCAA CCAGGGCGCG TCCGCACAGA CTTGGAGGCG GCTGCATGCT GCTACCTGCT 120 CCAGAAGCGT CCGGTGGCCG CCGC 144 (2) INFORMATION FOR SEQ ID NO:1885: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 144 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1885: GCCCTGTCGG GCGGGBBGCC TCTCTCCTCT CCCCBGBTCC GCGBCBGGCC GCBGGCBBGB 60 BCCBGCGCBB CCBGGGCGCG TCCGCBCBGB CTTGGBGGCG GCTGCBTGCT GCTBCCTGCT 120 CCBGBBGCGT CCGGTGGCCG CCGC 144 (2) INFORMATION FOR SEQ ID NO:1886: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 784 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1886: GTCTGTCTC CCCGTCTCCT CCCACTGCTT CTCCCGGGGG CTTCCCCGGC TTCGGGTGGC 60 CGGTGTCCCG GGCTCCGGCG CGGCGGCGGC TTCGGCTGCG GCTGGGTGGC GCGGGCTGCC 120 GGGTCCGCGC GGCGCCTGGG CCCTTGTGCT GCTTTTTGCT TGTTCCCTTC TGGCTGCTCC 180 GGTCTGTGTT GTGGTTGTTT TGTTTCTTCT TGGGTGTGGG CCTTGCGGTT TTGGCTGTGG 240 GCCCTTT(GG GCCTTGGCTT CTGCTCGTC TGTCCTCCCC TCTCCTCCC ACTGCTTCTC 300 CCGGGGGCTT CCCCGGCTTC GGGTGCCGG TGTCCCGGGC TCCGGCGCGG CGGCGGCTTC 360 GGCTGCGGGT GGGTGGCGCG GGCTGCCGGG TCCGCGCGGC GCCTGGGCCC TTGTGCTGCT 420 TTTTGCTTGT TCCGTTCTGG CTGCTCCGGT CTGTGTTGTG GTTGTTTTGT TTCTTCTTGC 480 GTGTGGGCCT TGCGGTTTTG GCTGTGGGCC CTTTGGGGCC TTCGCTTCTG GCTCCATCCA 540 CATGATTGCT TAGATTTGTG CTGTATCTCT CAGGATTATC ACTGATTACA CATCCAACCA 600 WO 00/09525 PCTIUS99/17712 502 GTGCCAGCCA AAAGGATGCC CTGAGGCAAA GGGTTTCCAT CTTGAGGCAA ATTTGAGGAC 660 BTCCBCBTGB TTGCTTBGBT TTGTGCTGTB TCTCTCBGGB TTBTCBCTGB TTBCBCBTCC 720 BBCCBGTGCC BGCCBBBBGG BTGCCCTGBG GCBBBGGGTT TCCBTCTTGB GGCBBBTTTG 780 BGGB 784 (2) INFORMATION FOR SEQ ID NO:1887: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 11 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1887: GBGGCBBBGG G 11 (2) INFORMATION FOR SEQ ID NO:1888: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1888: GCCBGCCBBB BGGB 14 (2) INFORMATION FOR SEQ ID NO:1889: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 11 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1889: CGCCTGGGCC C (2) INFORMATION FOR SEQ ID NO:1890: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 349 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1890: CTGCTGBGGC TTGGGTCTCC GGGCGBTTCT CTGCBGBBGB TGCTCBBBGG GCTCCGGCBG 60 TTCCTCCTTG BTCTGGTCGC TGTCGTBCCB GTCGGBCCBG TBBTTCBGBT CBTCBTTGGC 120 TCCTBTTTCT TCTGCBBBCB GCTGBGTGGB GBCBBGBBBB BBGBCTGCCB BGGCCBCGBG 180 GBTTTTCBTG TTGGBTTTTG CGBCGGBCBG TCCCGCGGGG TGCTGAGTTT CTCTGGTTCC 240 TCCGBGCGCB CGTGGTCGCT CCGCGTTTCT CTGGTTCCTC CGGTCCCGCG GGGTGCTGTC 300 TGGTCGCTGT CGTGGCTTGG GTCTCCGGGC GGTTTCCTTC CTTTTCCGC 349 (2) INFORMATION FOR SEQ ID NO:1891: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 10 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1891: CTCCGGGCGB 10 (2) INFORMATION FOR SEQ ID NO:1892: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 10 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1892: GGCCBCGBGG 10 (2) INFORMATION FOR SEQ ID NO:1893: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 13 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1893: GGGTCTCCGG GCG 13 (2) INFORMATION FOR SEQ ID NO:1894: (i) SEQUENCE
CHARACTERISTICS:
WO 00/09525 PCTIUS99/17712 EPI-109 503 (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1894: GGGTCTCCGG GCGG 14 (2) INFORMATION FOR SEQ ID NO:1895: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 250 base pairs (3) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1895: CTGCTGBGGC TTGGGTCTCC GGGCGBTTCT CTGCBGBBGB TGCTCBBBGG GCTCCGGCBG 60 TTCCTCCTTG BTCTGGTCGC TGTCGTBCCB GTCGGBCCBG TBBTTCBGBT CBTCBTTGGC 120 TCCTBTTTCT TCTGCBBBCB GCTGBGTGGB GBCBBGBBBH BBGBCTGCCB BGGCCBCGBG 180 GBTTTTCBTG TTGGBTTTTG CGBCGGBCBG TCCCGCGGGG TGCTGAGTTT CTCTGGTTCC 240 TCCGBGCGCB 250 (2) INFORMATION FOR SEQ ID NO:1896: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 662 base pairs (3) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1896: GGGCTBBGBT GBTCCBCBTC BCTBCCBCGT TGCCCBCCBC BGBGGTCBCC BCBBTGBCCG 60 TGTBGGCBGC TGCCCBBBGG BCBBTTTGCC BGGCTGGTTG CBCGBBCTGB TTGGGTTCCG 120 BGGTGTTBGT GGBGBTGTTT GGGGBGBGGT CTGBGTCCBC CGGGBGGBCG TTBTCCBTTT 180 CGBBGCTBGG CGGTBBBGCC CTBCTBTCTG TBCBCBBCCC CCCTCTGCBG CBGBGTCCTG 240 TCGTGGCGCC TGGGGCTCBG GGTCCGGGCT AAGATGATCC ACATCACTAC CACGTTGCCC 300 ACCACAGAGG TCACCACAAT GACCGTGTAG GCAGCTGCCC AAAGGACAAT TTGCCAGGCT 360 GGTTGCACGA ACTGATTGGG TTCCGAGGTG TTAGTGGAGA TGTTTGGGGA GAGGTCTGAG 420 TCCACCGGGA GGACGTTATC CATTTCGAAG CTAGGCGGTA AAGCCCTACT ATCTGTACAC 480 AACCCCCCTC TGCAGCAGAG TCCTGTCGTG GCGCCTGGGG CTCAGGGTCC GTCCTGTCGT 540 GGCGCCTGGG GCTCTTCTTT TGTGGGCTCT TTGGTGGCTG TGGCTGTGGT CTCTGTGGTT 600 GCTGCCCTGG GTCTGGGGGT GTGGCCTTGG GGCCGTCCTC TGGCTCCTCC TCGTGGGCCC 660 cc 662 (2) INFORMATION FOR SEQ ID NO:1897: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 9 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1897: GGGBGGBCG 9 (2) INFORMATION FOR SEQ ID NO:1898: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 7 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1898: GGGTCCG 7 (2) INFORMATION FOR SEQ ID NO:1899: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 8 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1899: GGGCCCCC 8 (2) INFORMATION FOR SEQ ID NO:1900: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 567 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1900: GGBGCTGBTB CTGCBGATTT CBGBGGGBBG BBCCCTGBTB CTCBCCBGCT TCBGCTCTGG 60 WO 00/09525 PCTUS99/17712 504 BGCBCBBGBG BBBGBGCBGC BGGGGGBGBG GBBGBBGCBG CBTCTTCCCB GBGBGGCTGC 120 CTGBGCBBBT GCTGGTTTTC CTTTCCBGTC TTGGGTTTTB TBBCTCCCBG BBGGCBBGBG 180 BGGGGCBBGG CGTTTTCTTC TCTCGCTGGT TTTCCTTTCC TGGCAGTGGG TGGGGGTGGG 240 GGTGGGGTGG CTTCCTTGTT CCTGGGGGTG TCCTCTTGCT CTGGGCTTTT CTCCCCTTTT 300 CCTTCCTGTC TGTTTTCCTG GGGCTCTCCT CTGTCTCTGT GTCCTTGCCC TGGCCCTCTT 360 CCCTCTCCTG TCTCCTGTCC CTGTGTTCCG CCCGTCTTCC CTCTCCTGAC CTCCTTTTCC 420 TCCGCTGGGT GGGGCCCTGC CTGTTCTCTG CTCCCTGGCT TGGGGTTTCT TCTGTGTGTC 480 TTCTTCCTCT GTTGGCTGGC TTTCTCCTTC TTTTGTCTTC CTGGGTGCCC CTTCTTCCTT 540 TCTTGGGTCC TTGGTGCTTG GGCTGGG 567 (2) INFORMATION FOR SEQ ID NO:1901: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 10 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1901: GGBGCBCBBG 10 (2) INFORMATION FOR SEQ ID NO:1902: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 8 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (T) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1902: GBBGCBGC 8 (2) INFORMATION FOR SEQ ID NO:1903: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 11 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1903: GGGGCBBGGC G 11 (2) INFORMATION FOR SEQ ID NO:1904: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 190 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1904: GGBGCTGBTB CTGCBGATTT CBGBGGGBBG BBCCCTGBTB CTCBCCBGCT TCBGCTCTGG 60 BGCBCBBGBG BBBGBGCBGC BGGGGGBGBG GBBGBBGCBG CBTCTTCCCB GBGBGGCTGC 120 CTGBGCBBBT CCTGGTTTTC CTTTCCBCTC TTGGGTTTTB TBBCTCCCBG BBGGCBBGBG 180 BGGGGCBBGG 190 (2) INFORMATION FOR SEQ ID NO:1905: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 2028 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1905: GCGTCTTGGG GTGCBGGGCC CBTCCTGCTG CGCCTGGGCG CTGCTGTGCG TCCGTCTGCT 60 GGGGGGCCGG GGTGGCTGGG CCCTGCTTGC CGCACGACCC CGGGCCGACC CGAGGCTCGG 120 GGGGCTGTGT TCTGGCGCTG GTGGGCTTGG GCCCCTCTGG GGGCTGGGTT TCCTGCTGCC 180 CCTGGGCGCT GGCGTCTTGG GGTGCGGGGC CGGGGGGCCG GGGGGCCGCT GTTCGTGGGC 240 CTGGGGGTGC CTGTGGCTGC CGGTTGCCCC GGTTGGTGGC GCCGTCCTGC TGCCGGTCGT 300 TGGCTGGGTC CCCCCGCCCG TTTCCTGGGG TCCGCGTGGG GTGCTCCGGT TCCTCGTGCC 360 GCTGCTGCCT TGTCTTTCCG GCCGTGGCGG CGTGGTGGTC CCCCCCCCCT GGCCTTCTGC 420 TCGGGGTCTG GCTGGTTGCC GGTGCCCTTG GCGGCGGTCT TCTTCCTGGT GGCTCTGGGC 480 CCGGCCGGTC TCGGGCGTCT CGTGTTCGCT CTTGTGCTGT TCCGGCCGCT CCTTCCTCTT 540 CCGCCGCCGC CGCTCCCCGC CCGCTCGTCG CCCTGGCCCG GCCTCCTCCT GGCCGCTGTC 600 TCGGGCGGCG GCCTTGGCGC TCCGTTTGGG GCTGCCTCTG GCGCTTCCGG CCCTCGGCCT 660 GGGCGCTCTC TTCCGCCTGT GCTGGTGGCC CTCGTGGGCC CCTCCTGGCC TCCGGTGTCC 720 TGTGGTCCCC CGGCTGGTGG CCGGGCCGGT TGGGCGGGCG TGGGCGCCGG CGGGTCCTCC 780 GGGCTGCCCT TCTCCGCCGG GGGTCCCGCG CTCCTGCTGT TCCCTGGGCT CTTCTGCCTC 840 TCTCCTGGGT GGGTGCTGGG TGCCGGGGTC TCCGGGCTTG CCCCGCGCTG CTGGGCGTTC 900 TGCGGTCTTG GGGTTGTCTG TGGCCCCGCT CGTGTCGCCC TCCGTCCCCC GTCGCCGGCC 960 TCGTCCCCTC CTGGGTGCGC CGCGGGCTGG TCCTGGCGTT TTCCTCCTTC CTGGGCGTCT 1020 TGGGGTGCBG GGCCCBTCCT GCTGCGCCTG GGCGCTGCTC TGCGTCCCTC TGCTGGGGGG 1080 CCGGGGTGGC TGGGCCCTCC TTGCCGCACG ACCCCGGGCC GACCCGAGGC TCGGGGGGCT 1140 WO 00/09525 PCT/US99/17712 505 GTGTTCTGGC GCTGGTGGGC TTGGGCCCCT CTGGGGGCTG GGTTTCCTGC TC UUUTGGG 1200 CGCTGGCGTC TTGGGGTGCG GGGCCGGGGG GCCGGGGGGC CGCTGTTCGT GGGCCTGGGG 1260 GTGCCTGTGG CTGCCGGTTG CCCCGGTTGG TGGCGCCGTC CTGCTGCCGG TCGTTGGCTG 1320 GGTCCCCCCG CCCGTTTCCT GGGGTCCGCG TGGGGTGCTC CGGTTCCTCG TGCCGCTGCT 1380 GCCTTGTCTT TCCGGCCGTG GCGGCGTGGT GGTCCGCCCC CCCTGGCCTT CTGCTCGGGG 1440 TCTGGCTGGT TGCCGGTGCC CTTGGCGGCG GTCTTCTTCC TGGTGGCTCT GGGCCCGGCC 1500 GGTCTCGGGC GTCTCGTGTT CGCTCTTGTG CTGTTCCGGC CGCTCCTTCC TCTTCCGCCG 1560 CCGCCGCTCC CCGCCCGCTC GTCGCCCTGG CCCGGCCTCC TCCTGGCCGC TGTCTCGGGC 1620 GGCGGCCTTG GCGCTCCGTT TGGGGCTGCC TCTGGCGCTT CCGGCCCTCG GCCTGGGCGC 1680 TCTCTTCCGC CTGTGCTGGT GGCCCTCGTG GGCCCCTCCT GGCCTCCGGT GTCCTGTGGT 1740 CCCCCGGCTG GTGGCCGGGC CGGTTGGGCG GGCGTGGGCG CCGGCGGGTC CTCCGGGCTG 1800 CCCTTCTCCG CCGGGGGTCC CGCGCTCCTG CTGTTCCCTG GGCTCTTCTG CCTCTCTCCT 1860 GGGTGGGTGC TGGGTGCCGG GGTCTCCGGG CTTGCCCCGC GCTGCTGGGC GTTCTGCGGT 1920 CTTGGGGTTG TCTGTGGCCC CGCTCGTGTC GCCCTCCGTC GCCCGTCGCC GGCCTCGTCC 1980 CCTCCTGGGT GCGCGGCGGG CTGGTCCTGG CGTTTTGCTC CTTCCTGG 2028 (2) INFORMATION FOR SEQ ID NO:1906: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 9 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1906: GCGGGGCCG 9 (2) INFORMATION FOR SEQ ID NO: 1907: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 8 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1907: CGGGGGGC 8 (2) INFORMATION FOR SEQ ID NO:1908: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 11 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1908: GCGCGGCGGG C 11 (2) INFORMATION FOR SEQ ID NO:1909: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 43 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1909: GCGTCTTGGG GTGCBGGGCC CBTCCTGCTG CGCCTGGGCG CTG 43 (2) INFORMATION FOR SEQ ID NO:1910: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 535 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1910: CTGCCCCBGT TTTTGBTCCT CBCBTGCCGT GGGGBGGBCB BTGGCTGCCT CCCCGGGGTT 60 TCTGCTGCTT GCTGCTTCTT TCCCGTCTCC CTTCTTTCCC GTCTCCTTTT TGCCTCTTTG 120 GGTTCCTGTT GTTTCTGGCC TGCTTGGTGG CGGCTTGTGC GTTTCCTCTC TCTTCTCTTG 180 GGTCTCCGCT TCTCGTCCTG CCTTTTCCTG TCTCTGTCGC GCCGTTCCTC CTCCGGCGTC 240 CTCCTGCCCT GTGCTGTTTG CCTCGGGTGG TGCGGGTCCC GGTGCTCCCC CGGCGGGCCG 300 GCTGGTTGCC TGGGCCTGrC TGGTGGGGTG TGGGGCCGCT GGGTTGGGGG TGTGGTGGGC 360 TCTTCTGTGG CCTGTGGGGC TGTTGGTGTC TCTGTGGGCG TGTGCTGGGT CTTGGGGCTT 420 CCTCCCTTGT GCTGGGTGCG GCCTCCCCGC CCCCCTTCTG GGCCGGTGGC CTGGCTCCTT 480 GTGGGCGCTT CTGGCTCTTG CCCTGTCCTT CTTCGCCTCG TGGCTGCTGG GCTGC 535 (2) INFORMATION FOR SEQ ID NO:1911: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 8 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear WO 00/09525 PCT/US99/17712 506 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1911: CCCCGGGG 8 (2) INFORMATION FOR SEQ ID NO:1912: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 12 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1912: GGGGCCGCTG GG 12 (2) INFORMATION FOR SEQ ID NO:1913: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 10 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1913: GGGGGTGTGG 10 (2) INFORMATION FOR SEQ ID NO:1914: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 44 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1914: CTGCCCCBGT TTTTGBTCCT CBCBTGCCGT GGGGBGGBCB BTGG 44 (2) INFORMATION FOR SEQ ID NO:1915: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 756 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1915: CGGCCCTTCT CACTGGAGGC ACCGGGCAGT CCTCCATGGG AGGGTTGGGC TTGGCCGGGG 60 CTGCCCGGTG CCTCCTCTTG GCTGGTCCCT CGTTGTCCTT GGGCCCCGCT CCCGCTGCTC 120 GGCCTCCGTG TTCTTTGGCC TCTTGCTCCG CCTGCTGTCT TGTCCCGTCC CCTCCTCGCT 180 TGCGTTTCCC TCTTCCTTGT CTTCCAGGCC TTCCTCCGCT TCCGCTGCTG GGGCCCGCGC 240 CGGGGGGGCG CTCGGCTCCG CGGCTTCCTC CCCGGCTGGG GGGTCCTGGT CTCCGGGGCC 300 TGCGGCTCGC GGGCTCGGGG CTGCGTGCGC CGCGCGCGGC GTCCGCGGTG GGTGGCGCTG 360 TCCCGCCGTG GTGTGTCTCC GTTCTCGTCC TGCGCCGTCC TGGTCTGCCC GTGGGGTCCT 420 GGGCGTGGTG GGGGGCGTCT GGTGCCTCGT CTGCCCCGTG GGGCTTCGGG CTCGGGGCTG 480 TTCGTCCCCC CTGCCGCTCT GTGGCCTCCG GGGCTCCTCG TTTTCGCTGC TTCGGGTGTC 540 CTTCTCGGCG TGTGGCCCCG GGTCCCGGCC CTGCTGGGCT GGGCGGGGTC GCTGCCCTGG 600 GCTTCTGGCC CGTCTGGTTG TCTGTCGGTG CTTGTCTCGG GTTTCTGGCC TCTGTGCTGG 660 GCGCTTCTCT GCCTCCTGCT CCGCCCTCCT GGTGGCTCGG CTGGGGGTGC CCGTGCGGGG 720 GTGGGTGTGG GGTGTTTTCG GGGTCCTCCC CTTCCC 756 (2) INFORMATION FOR SEQ ID NO:1916: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 12 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1916: GGGCGGGGTC GC 12 (2) INFORMATION FOR SEQ ID NO:1917: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 9 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1917: GCGCCGTCC 9 (2) INFORMATION FOR SEQ ID NO:1918: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 11 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear WO 00/09525 PCT/US99/17712 507 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1918: GGGCGTGGTG G 11 (2) INFORMATION FOR SEQ ID NO:1919: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 43 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1919: CGGCCCTTCT CACTGGAGGC ACCGGGCAGT CCTCCATGGG AGG 43 (2) INFORMATION FOR SEQ ID NO:1920: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 302 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1920: GTTTCATCTT GGCTTTATCC TCTCCCCTTG TTCCTCCCCT CTCCTGCTCT GGRGTCTCCT 60 CTTCCCTCCC TCCCCTGCCG TGTTGTCTGT GGGTGTCGTT TCGCTCTTGT TGCCCTGGGC 120 CCTTCCCTGC TGGGGGGGAG TTTCATCTTG GGTTTCBTCT TGGCTTTBTC CTCTCCCCTT 180 GTTCCTCCCC TCTCCTGCTC TGGRGTCTCC TCTTCCCTCC CTCCCCTGCC GTGTTGTCTG 240 TGGGTGTCGT TTCGCTCTTG TTGCCCTGGG CCCTTCCCTG CTGGGGGGGB GTTTCBTCTT 300 GG 302 (2) INFORMATION FOR SEQ ID NO:1921: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 9 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1921: GGGGGAGTT 9 (2) INFORMATION FOR SEQ ID NO:1922: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 11 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1922: GCCCTGGGCC C 11 (2) INFORMATION FOR SEQ ID NO:1923: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 151 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1923: GTTTCATCTT GGCTTTATCC TCTCCCCTTG TTCCTCCCCT CTCCTGCTCT GGRGTCTCCT 60 CTTCCCTCCC TCCCCTGCCG TGTTGTCTGT GGGTGTCGTT TCGCTCTTGT TGCCCTGGGC 120 CCTTCCCTGC TGGGGGGGAG TTTCATCTTG G 151 (2) INFORMATION FOR SEQ ID NO:1924: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 151 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1924: GTTTCBTCTT GGCTTTBTCC TCTCCCCTTG TTCCTCCCCT CTCCTGCTCT GGRGTCTCCT 60 CTTCCCTCCC TCCCCTGCCG TGTTGTCTGT GGGTGTCGTT TCGCTCTTGT TGCCCTGGGC 120 CCTTCCCTGC TGGGGGGGBG TTTCBTCTTG G 151 (2) INFORMATION FOR SEQ ID NO:1925: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 7 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1925: GGGGGBG 7 WO 00/09525 PCT/US99/17712 508 (2) INFORMATION FOR SEQ ID NO:1926: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 10 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1926: GTGGGTGTCC 10 (2) INFORMATION FOR SEQ ID NO:1927: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 91 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1927: CCGTGTTGTC BGTGGTGCTG CCCGTTTGBG GTBTGGCGCT CCBCCBBTTC CCTTTTCTCC 60 TTGTTTTCCG TTTCTCTTGC CGTCTGTGGT T 91 (2) INFORMATION FOR SEQ ID NO:1928: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 17 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1928: CCCGTTTGBG GTBTGGC 17 (2) INFORMATION FOR SEQ ID NO:1929: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 23 base pairs (B) TYPE: nucleic acid (C),STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1929: GCTCCBCCBB TTCCCTTTTC TCC 23 (2) INFORMATION FOR SEQ ID NO:1930: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1930: TTGTTTTCCG TTTCTCTTG 19 (2) INFORMATION FOR SEQ ID NO:1931: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 12 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1931: CCGTCTGTGG TT 12 (2) INFORMATION FOR SEQ ID NO:1932: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 17 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1932: CCCGTTTGAG GTATGGC 17 (2) INFORMATION FOR SEQ ID NO:1933: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 23 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1933: GCTCCBCCAA TTCCCTTTTC TCC 23 (2) INFORMATION FOR SEQ ID NO:1934: (i) SEQUENCE CHARACTERISTICS: WO 00/09525 PCT/US99/177-12 11-au 509 (A) LENGTH: 34 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1934: GGGCCCBGCC CCGCCGCCTT TTCTBGCCCC GGCC 34 (2) INFORMATION FOR SEQ ID NO:1935: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 33 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1935: GGGCCCBGCC CCGCCGCCTT TTCTBGCCCC GGC 33 (2) INFORMATION FOR SEQ ID NO:1936: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 32 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1936: GGGCCCBGCC CCGCCGCCTT TTCTBGCCCC GG 32 (2) INFORMATION FOR SEQ ID NO:1937: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 31 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1937: GGGCCCBGCC CCGCCGCCTT TTCTBGCCCC G 31 (2) INFORMATION FOR SEQ ID NO:1938: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 30 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1938: GGGCCCBGCC CCGCCGCCTT TTCTBGCCCC 30 (2) INFORMATION FOR SEQ ID NO:1939: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 29 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1939: GGGCCCBGCC CCGCCGCCTT TTCTBGCCC 29 (2) INFORMATION FOR SEQ ID NO:1940: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 28 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1940: GGGCCCBGCC CCGCCGCCTT TTCTBGCC 28 (2) INFORMATION FOR SEQ ID NO:1941: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 27 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1941: GGGCCCBGCC CCGCCGCCTT TTCTBGC- 27 (2) INFORMATION FOR SEQ ID NO:1942: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 26 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single WO 00/09525 PCT/US99/17712 rri-ivy 510 (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1942: GGGCCCBGCC CCGCCGCCTT TTCTBG 26 (2) INFORMATION FOR SEQ ID NO:1943: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 25 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1943: GGGCCCBGCC CCGCCGCCTT TTCTB 25 (2) INFORMATION FOR SEQ ID NO:1944: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 24 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1944: GGGCCCBGCC CCGCCGCCTT TTCT 24 (2) INFORMATION FOR SEQ ID NO:1945: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 23 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1945: GGGCCCBGCC CCGCCGCCTT TTC 23 (2) INFORMATION FOR SEQ ID NO:1946: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1946: GGGCCCBGCC CCGCCGCCTT TT 22 (2) INFORMATION FOR SEQ ID NO:1947: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 21 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1947: GGGCCCBGCC CCGCCGCCTT T 21 (2) INFORMATION FOR SEQ ID NO:1948: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 20 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1948: GGGCCCBGCC CCGCCGCCTT 20 (2) INFORMATION FOR SEQ ID NO:1949: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1949: GGGCCCBGCC CCGCCGCCT 19 (2) INFORMATION FOR SEQ ID NO:1950: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1950: GGGCCCBGCC CCGCCGCC 18 WO 00/09525 PCT/US99/17712 511 (2) INFORMATION FOR SEQ ID NO:1951: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 17 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1951: GGGCCCBGCC CCGCCGC 17 (2) INFORMATION FOR SEQ ID NO:1952: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 16 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1952: GGGCCCBGCC CCGCCG 16 (2) INFORMATION FOR SEQ ID NO:1953: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1953: GGGCCCBGCC CCGCC 15 (2) INFORMATION FOR SEQ ID NO:1954: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1954: GGGCCCBGCC CCGC 14 (2) INFORMATION FOR SEQ ID NO:1955: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 13 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1955: GGGCCCBGCC CCG 13 (2) INFORMATION FOR SEQ ID NO:1956: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 12 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1956: GGGCCCBGCC CC 12 (2) INFORMATION FOR SEQ ID NO:1957: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 11 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1957: GGGCCCBGCC C (2) INFORMATION FOR SEQ ID NO:1958: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 32 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1958: GGCCCBGCCC CGCCGCCTTT TCTBGCCCCG GC 32 (2) INFORMATION FOR SEQ ID NO:1959: (i) SEQUENCE CHARACTERISTICS: WO 00/09525 PCT/US99/17712 512 (A) LENGTH: 31 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1959: GCCCBGCCCC GCCGCCTTTT CTBGCCCCGG C 31 (2) INFORMATION FOR SEQ ID NO:1960: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 30 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1960: CCCBGCCCCG CCGCCTTTTC TBGCCCCGGC 30 (2) INFORMATION FOR SEQ ID NO:1961: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 29 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1961: CCBGCCCCGC CGCCTTTTCT BGCCCCGGC 29 (2) INFORMATION FOR SEQ ID NO:1962: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 28 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1962: CBGCCCCGCC GCCTTTTCTB GCCCCGGC 28 (2) INFORMATION FOR SEQ ID NO:1963: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 27 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear' (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1963: BGCCCCGCCG CCTTTTCTBG CCCCGGC 27 (2) INFORMATION FOR SEQ ID NO:1964: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 26 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1964: GCCCCGCCGC CTTTTCTBGC CCCGGC 26 (2) INFORMATION FOR SEQ ID NO:1965: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 25 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1965: CCCCGCCGCC TTTTCTBGCC CCGGC 25 (2) INFORMATION FOR SEQ ID NO:1966: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 24 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1966: CCCGCCGCCT TTTCTBGCCC CGGC 24 (2) INFORMATION FOR SEQ ID NO:1967: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 23 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single WO 00/09525 PCT/US99/17712 LI-IU9 513 (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1967: CCGCCGCCTT TTCTBGCCCC GGC 23 (2) INFORMATION FOR SEQ ID NO:1968: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1968: CGCCGCCTTT TCTBGCCCCG GC 22 (2) INFORMATION FOR SEQ ID NO:1969: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 21 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1969: GCCGCCTTTT CTBGCCCCGG C 21 (2) INFORMATION FOR SEQ ID NO:1970: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 20 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1970: CCGCCTTTTC TBGCCCCGGC 20 (2) INFORMATION FOR SEQ ID NO:1971: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1971: CGCCTTTTCT BGCCCCGGC 19 (2) INFORMATION FOR SEQ ID NO:1972: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (H) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1972: GCCTTTTCTB GCCCCGGC 18 (2) INFORMATION FOR SEQ ID NO:1973: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 17 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1973: CCTTTTCTBG CCCCGGC 17 (2) INFORMATION FOR SEQ ID NO:1974: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 16 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1974: CTTTTCTBGC CCCGGC 16 (2) INFORMATION FOR SEQ ID NO:1975: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (3) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1975: TTTTCTBGCC CCGGC 15 WO 00/09525 PCT/US99/17712 514 (2) INFORMATION FOR SEQ ID NO:1976: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1976: TTTCTBGCCC CGGC 14 (2) INFORMATION FOR SEQ ID NO:1977: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 13 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1977: TTCTBGCCCC GGC 13 (2) INFORMATION FOR SEQ ID NO:1978: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 12 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1978: TCTBGCCCCG GC 12 (2) INFORMATION FOR SEQ ID NO:1979: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 11 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1979: CTBGCCCCGG C 11 (2) INFORMATION FOR SEQ ID NO:1980: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 25 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1980: GCGBGGCTGT CBCCTCGCTG GGCCC 25 (2) INFORMATION FOR SEQ ID NO:1981: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 24 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1981: GCGBGGCTGT CBCCTCGCTG GGCC 24 (2) INFORMATION FOR SEQ ID NO:1982: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 23 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1982: GCGBGGCTGT CBCCTCGCTG GGC 23 (2) INFORMATION FOR SEQ ID NO:1983: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 base pairs (H) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1983: GCGBGGCTGT CBCCTCGCTG GG 22 (2) INFORMATION FOR SEQ ID NO:1984: (i) SEQUENCE CHARACTERISTICS: WO 00/09525 PCT/US99/17712 tLri-tuy 515 (A) LENGTH: 21 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1984: GCGBGGCTGT CBCCTCGCTG G 21 (2) INFORMATION FOR SEQ ID NO:1985: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 20 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1985: GCGBGGCTGT CBCCTCGCTG 20 (2) INFORMATION FOR SEQ ID NO:1986: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1986: GCGBGGCTGT CBCCTCGCT 19 (2) INFORMATION FOR SEQ ID NO:1987: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1987: GCGBGGCTGT CBCCTCGC 18 (2) INFORMATION FOR SEQ ID NO:1988: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 17 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1988: GCGBGGCTGT CBCCTCG 17 (2) INFORMATION FOR SEQ ID NO:1989: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 16 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1989: GCGBGGCTGT CBCCTC 16 (2) INFORMATION FOR SEQ ID NO:1990: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1990: GCGBGGCTGT CBCCT 15 (2) INFORMATION FOR SEQ ID NO:1991: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid .(C) STRANDEDNESS: single (D) TOPOLOGY: linear. (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1991: GCGBGGCTGT CBCC 14 (2) INFORMATION FOR SEQ ID NO:1992: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 13 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single WO 00/09525 PCT/US99/17712 Cri-iu'' 516 (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1992: GCGBGGCTGT CBC 13 (2) INFORMATION FOR SEQ ID NO:1993: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 12 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1993: GCGBGGCTGT CB 12 (2) INFORMATION FOR SEQ ID NO:1994: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 11 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1994: GCGBGGCTGT C 11 (2) INFORMATION FOR SEQ ID NO:1995: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 10 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1995: GCGBGGCTGT 10 (2) INFORMATION FOR SEQ ID NO:1996: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 24 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1996: CGBGGCTGTC BCCTCGCTGG GCCC 24 (2) INFORMATION FOR SEQ ID NO:1997: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 23 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1997: GBGGCTGTCB CCTCGCTGGG CCC 23 (2) INFORMATION FOR SEQ ID NO:1998: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1998: BGGCTGTCBC CTCGCTGGGC CC 22 (2) INFORMATION FOR SEQ ID NO:1999: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 21 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1999: GGCTGTCBCC TCGCTGGGCC C 21 (2) INFORMATION FOR SEQ ID NO:2000: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 20 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2000: GCTGTCBCCT CGCTGGGCCC 20 WO 00/09525 PCTIUS99/17712 EPI-109 517 (2) INFORMATION FOR SEQ ID NO:2001: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2001: CTGTCBCCTC GCTGGGCCC 19 (2) INFORMATION FOR SEQ ID NO:2002: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2002: TGTCBCCTCG CTGGGCCC 18 (2) INFORMATION FOR SEQ ID NO:2003: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 17 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2003: GTCBCCTCGC TGGGCCC 17 (2) INFORMATION FOR SEQ ID NO:2004: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 16 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2004: TCBCCTCGCT GGGCCC 16 (2) INFORMATION FOR SEQ ID NO:2005: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2005: CBCCTCGCTG GGCCC 15 (2) INFORMATION FOR SEQ ID NO:2006: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2006: BCCTCGCTGG GCCC 14 (2) INFORMATION FOR SEQ ID NO:2007: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 13 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2007 CCTCGCTGGG CCC 13 (2) INFORMATION FOR SEQ ID NO:2008: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 12 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2008: CTCGCTGGGC CC 12 (2) INFORMATION FOR SEQ ID NO:2009: (i) SEQUENCE
CHARACTERISTICS:
WO 00/09525 PCT/US99/17712 en-mUY 518 (A) LENGTH: 11 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2009: TCGCTGGGCC C (2) INFORMATION FOR SEQ ID NO:2010: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 10 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2010: CGCTGGGCCC 10 (2) INFORMATION FOR SEQ ID NO:2011: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 31 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2011: GCGCGGCCGT CBTGGCGGCG TCGGGCCGGG C 31 (2) INFORMATION FOR SEQ ID NO:2012: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 30 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2012: GCGCGGCCGT CBTGGCGGCG TCGGGCCGGG 30 (2) INFORMATION FOR SEQ ID NO:2013: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 29 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2013: GCGCGGCCGT CBTGGCGGCG TCGGGCCGG 29 (2) INFORMATION FOR SEQ ID NO:2014: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 28 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2014: GCGCGGCCGT CBTGGCGGCG TCGGGCCG 28 (2) INFORMATION FOR SEQ ID NO:2015: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 27 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2015: GCGCGGCCGT CBTGGCGGCG TCGGGCC 27 (2) INFORMATION FOR SEQ ID NO:2016: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 26 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2016: GCGCGGCCGT CBTGGCGGCG TCGGGC 26 (2) INFORMATION FOR SEQ ID NO:2017: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 25 base pairs (B) TYPE: nucleic acid WO 00/09525 PCT/US99/17712 LPI-109 519 (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2017: GCGCGGCCGT CBTGGCGGCG TCGGG 25 (2) INFORMATION FOR SEQ ID NO:2018: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 24 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2018: GCGCGGCCGT CBTGGCGGCG TCGG 24 (2) INFORMATION FOR SEQ ID NO:2019: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 23 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2019: GCGCGGCCGT CBTGGCGGCG TCG 23 (2) INFORMATION FOR SEQ ID NO:2020: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2020: GCGCGGCCGT CBTGGCGGCG TC 22 (2) INFORMATION FOR SEQ ID NO:2021: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 21 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2021: GCGCGGCCGT CBTGGCGGCG T 21 (2) INFORMATION FOR SEQ ID NO:2022: (i) SEQUENCE CHARACTERISTICS: CA) LENGTH: 20 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2022: GCGCGGCCGT CBTGGCGGCG 20 (2) INFORMATION FOR SEQ ID NO:2023: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2023: GCGCGGCCGT CBTGGCGGC 19 (2) INFORMATION FOR SEQ ID NO:2024: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2024: GCGCGGCCGT CBTGGCGG 18 (2) INFORMATION FOR SEQ ID NO:2025: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 17 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2025: WO 00/09525 PCT/US99/17712 ri-ov 520 GCGCGGCCGT CBTGGCG 17 (2) INFORMATION FOR SEQ ID NO:2026: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 16 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2026: GCGCGGCCGT CBTGGC 16 (2) INFORMATION FOR SEQ ID NO:2027: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2027: GCGCGGCCGT CBTGG 15 (2) INFORMATION FOR SEQ ID NO:2028: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2028: GCGCGGCCGT CBTG 14 (2) INFORMATION FOR SEQ ID NO:2029: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 13 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2029: GCGCGGCCGT CBT 13 (2) INFORMATION FOR SEQ ID NO:2030: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 12 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2030: GCGCGGCCGT CB 12 (2) INFORMATION FOR SEQ ID NO:2031: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 11 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2031: GCGCGGCCGT C 11 (2) INFORMATION FOR SEQ ID NO:2032: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 10 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2032: GCGCGGCCGT 10 . (2) INFORMATION FOR SEQ ID NO:2033: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 30 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2033: CGCGGCCGTC BTGGCGGCGT CGGGCCGGGC 30 (2) INFORMATION FOR SEQ ID NO:2034: WO 00/09525 PCTIUS99/17712 EPI-109 521 (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 29 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2034: GCGGCCGTCB TGGCGGCGTC GGGCCGGGC 29 (2) INFORMATION FOR SEQ ID NO:2035: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 28 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2035: CGGCCGTCBT GGCGGCGTCG GGCCGGGC 28 (2) INFORMATION FOR SEQ ID NO:2036: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 27 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2036: GGCCGTCBTG GCGGCGTCGG GCCGGGC 27 (2) INFORMATION FOR SEQ ID NO:2037: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 26 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2037: GCCGTCBTGG CGGCGTCGGG CCGGGC 26 (2) INFORMATION FOR SEQ ID NO:2038: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 25 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2038: CCGTCBTGGC GGCGTCGGGC CGGGC 25 (2) INFORMATION FOR SEQ ID NO:2039: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 24 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2039: CGTCBTGGCG GCGTCGGGCC GGGC 24 (2) INFORMATION FOR SEQ ID NO:2040: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 23 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2040: GTCBTGGCGG CGTCGGGCCG GGC 23 (2) INFORMATION FOR SEQ ID NO:2041: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2041: TCBTGGCGGC GTCGGGCCGG GC 22 (2) INFORMATION FOR SEQ ID NO:2042: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 21 base pairs (B) TYPE: nucleic acid WO 00/09525 PCT/US99/17712 EPI-109 522 (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2042: CBTGGCGGCG TCGGGCCGGG C 21 (2) INFORMATION FOR SEQ ID NO:2043: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 20 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2043: BTGGCGGCGT CGGGCCGGGC 20 (2) INFORMATION FOR SEQ ID NO:2044: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2044: TGGCGGCGTC GGGCCGGGC 19 (2) INFORMATION FOR SEQ ID NO:2045: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2045: GGCGGCGTCG GGCCGGGC 18 (2) INFORMATION FOR SEQ ID NO:2046: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 17 base pairs (H) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2046: GCGGCGTCGG GCCGGGC 17 (2) INFORMATION FOR SEQ ID NO:2047: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 16 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear ' (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2047: CGGCGTCGGG CCGGGC 16 (2) INFORMATION FOR SEQ ID NO:2048: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2048: GGCGTCGGGC CGGGC 15 (2) INFORMATION FOR SEQ ID NO:2049: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2049: GCGTCGGGCC GGGC 14 (2) INFORMATION FOR SEQ ID NO:2050: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 13 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2050: WO 00/09525 PCTIUS99/17712 EPI-109 523 CGTCGGGCCG GGC 13 (2) INFORMATION FOR SEQ ID NO:2051: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 12 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2051: GTCGGGCCGG GC 12 (2) INFORMATION FOR SEQ ID NO:2052: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 11 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2052: TCGGGCCGGG C 11 (2) INFORMATION FOR SEQ ID NO:2053: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 10 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2053: CGGGCCGGGC 10 (2) INFORMATION FOR SEQ ID NO:2054: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 32 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2054: CCGCBGGCCB GGGCGCGCCG CCGGCCGGGC CG 32 (2) INFORMATION FOR SEQ ID NO:2055: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 31 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2055: CCGCBGGCCB GGGCGCGCCG CCGGCCGGGC C 31 (2) INFORMATION FOR SEQ ID NO:2056: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 30 base pairs (3) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2056: CCGCBGGCCB GGGCGCGCCG CCGGCCGGGC 30 (2) INFORMATION FOR SEQ ID NO:2057: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 29 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2057: CCGCBGGCCB GGGCGCGCCG CCGGCCGGG 29 (2) INFORMATION FOR SEQ ID NO:2058: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 28 base pairs (H) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2058: CCGCBGGCCB GGGCGCGCCG CCGGCCGG 28 (2) INFORMATION FOR SEQ ID NO:2059: WO 00/09525 PCT/US99/17712 nr-ivy 524 (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 27 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2059: CCGCBGGCCB GGGCGCGCCG CCGGCCG 27 (2) INFORMATION FOR SEQ ID NO:2060: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 26 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2060: CCGCBGGCCB GGGCGCGCCG CCGGCC 26 (2) INFORMATION FOR SEQ ID NO:2061: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 25 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2061: CCGCBGGCCB GGGCGCGCCG CCGGC 25 (2) INFORMATION FOR SEQ ID NO:2062: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 24 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2062: CCGCBGGCCB GGGCGCGCCG CCGG 24 (2) INFORMATION FOR SEQ ID NO:2063: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 23 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2063: CCGCBGGCCB GGGCGCGCCG CCG 23 (2) INFORMATION FOR SEQ ID NO:2064: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2064: CCGCBGGCCB GGGCGCGCCG CC 22 (2) INFORMATION FOR SEQ ID NO:2065: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 21 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2065: CCGCBGGCCB GGGCGCGCCG C 21 (2) INFORMATION FOR SEQ ID NO:2066: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 20 base pairs .(B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2066: CCGCBGGCCB GGGCGCGCCG 20 (2) INFORMATION FOR SEQ ID NO:2067: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 base pairs (B) TYPE: nucleic acid WO 00/09525 PCTIUS99/17712 trl-su9 525 (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2067: CCGCBGGCCB GGGCGCGCC 19 (2) INFORMATION FOR SEQ ID NO:2068: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2068: CCGCBGGCCB GGGCGCGC 18 (2) INFORMATION FOR SEQ ID NO:2069: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 17 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2069: CCGCBGGCCB GGGCGCG 17 (2) INFORMATION FOR SEQ ID NO:2070: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 16 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2070: CCGCBGGCCB GGGCGC 16 (2) INFORMATION FOR SEQ ID NO:2071: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2071: CCGCBGGCCB GGGCG 15 (2) INFORMATION FOR SEQ ID NO:2072: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2072: CCGCBGGCCB GGGC 14 (2) INFORMATION FOR SEQ ID NO:2073: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 13 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2073: CCGCBGGCCB GGG 13 (2) INFORMATION FOR SEQ ID NO:2074: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 12 base pairs (3) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2074: CCGCBGGCCB GG 12 (2) INFORMATION FOR SEQ ID NO:2075: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 11 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2075: WO 00/09525 PCT/US99/17712 zri-my 526 CCGCBGGCCB G 11 (2) INFORMATION FOR SEQ ID NO:2076: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 10 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2076: CCGCBGGCCB 10 (2) INFORMATION FOR SEQ ID NO:2077: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 9 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2077: CCGCBGGCC 9 (2) INFORMATION FOR SEQ ID NO:2078: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 31 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2078: CGCBGGCCBG GGCGCGCCGC CGGCCGGGCC G 31 (2) INFORMATION FOR SEQ ID NO:2079: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 30 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2079: GCBGGCCBGG GCGCGCCGCC GGCCGGGCCG 30 (2) INFORMATION FOR SEQ ID NO:2080: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 29 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2080: CBGGCCBGGG CGCGCCGCCG GCCGGGCCG 29 (2) INFORMATION FOR SEQ ID NO:2081: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 28 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2081: BGGCCBGGGC GCGCCGCCGG CCGGGCCG 28 (2) INFORMATION FOR SEQ ID NO:2082: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 27 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2082: GGCCBGGGCG CGCCGCCGGC CGGGCCG 27 (2) INFORMATION FOR SEQ ID NO:2083: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 26 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2083: GCCBGGGCGC GCCGCCGGCC GGGCCG 26 (2) INFORMATION FOR SEQ ID NO:2084: WO 00/09525 PCT/US99/17712 527 (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 25 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2084: CCBGGGCGCG CCGCCGGCCG GGCCG 25 (2) INFORMATION FOR SEQ ID NO:2085: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 24 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2085: CBGGGCGCGC CGCCGGCCGG GCCG 24 (2) INFORMATION FOR SEQ ID NO:2086: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 23 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2086: BGGGCGCGCC GCCGGCCGGG CCG 23 (2) INFORMATION FOR SEQ ID NO:2087: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2087: GGGCGCGCCG CCGGCCGGGC CG 22 (2) INFORMATION FOR SEQ ID NO:2088: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 21 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2088: GGCGCGCCGC CGGCCGGGCC G 21 (2) INFORMATION FOR SEQ ID NO:2089: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 20 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2089: GCGCGCCGCC GGCCGGGCCG 20 (2) INFORMATION FOR SEQ ID NO:2090: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2090: CGCGCCGCCG GCCGGGCCG 19 (2) INFORMATION FOR SEQ ID NO:2091: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs .(B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2091: GCGCCGCCGG CCGGGCCG 18 (2) INFORMATION FOR SEQ ID NO:2092: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 17 base pairs (B) TYPE: nucleic acid WO 00/09525 PCT/US99/17712 ti 528 (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2092: CGCCGCCGGC CGGGCCG 17 (2) INFORMATION FOR SEQ ID NO:2093: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 16 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2093: GCCGCCGGCC GGGCCG 16 (2) INFORMATION FOR SEQ ID NO:2094: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2094: CCGCCGGCCG GGCCG 15 (2) INFORMATION FOR SEQ ID NO:2095: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2095: CGCCGGCCGG GCCG 14 (2) INFORMATION FOR SEQ ID NO:2096: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 13 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2096: GCCGGCCGGG CCG 13 (2) INFORMATION FOR SEQ ID NO:2097: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 12 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2097: CCGGCCGGGC CG 12 (2) INFORMATION FOR SEQ ID NO:2098: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 11 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2098: CGGCCGGGCC G 11 (2) INFORMATION FOR SEQ ID NO:2099: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 10 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2099: GGCCGGGCCG 10 (2) INFORMATION FOR SEQ ID NO:2100: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 16 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2100: WO 00/09525 PCTIUS99/17712 -.- 529 GGGCGCBGGC TCCGCB 16 (2) INFORMATION FOR SEQ ID NO:2101: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 46 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2101: GGGCCCCTGG CTCGGCCCCG CGGCCCGGCT TGCCCGCCCG GCCCGG 46 (2) INFORMATION FOR SEQ ID NO:2102: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 45 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2102: GGGCCCCTGG CTCGGCCCCG CGGCCCGGCT TGCCCGCCCG GCCCG 45 (2) INFORMATION FOR SEQ ID NO:2103: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 44 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2103: GGGCCCCTGG CTCGGCCCCG CGGCCCGGCT TGCCCGCCCG GCCC 44 (2) INFORMATION FOR SEQ ID NO:2104: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 43 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2104: GGGCCCCTGG CTCGGCCCCG CGGCCCGGCT TGCCCGCCCG GCC 43 (2) INFORMATION FOR SEQ ID NO:2105: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 42 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2105: GGGCCCCTGG CTCGGCCCCG CGGCCCGGCT TGCCCGCCCG GC 42 (2) INFORMATION FOR SEQ ID NO:2106: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 41 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2106: GGGCCCCTGG CTCGGCCCCG CGGCCCGGCT TGCCCGCCCG G 41 (2) INFORMATION FOR SEQ ID NO:2107: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 40 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2107: GGGCCCCTGG CTCGGCCCCG CGGCCCGGCT TGCCCGCCCG 40 (2) INFORMATION FOR SEQ ID NO:2108: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 39 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2108: GGGCCCCTGG CTCGGCCCCG CGGCCCGGCT TGCCCGCCC 39 (2) INFORMATION FOR SEQ ID NO:2109: WO 00/09525 PCTJS99/17712 rcriuy 530 (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 38 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2109: GGGCCCCTGG CTCGGCCCCG CGGCCCGGCT TGCCCGCC 38 (2) INFORMATION FOR SEQ ID NO:2110: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 37 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2110: GGGCCCCTGG CTCGGCCCCG CGGCCCGGCT TGCCCGC 37 (2) INFORMATION FOR SEQ ID NO:2111: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 36 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2111: GGGCCCCTGG CTCGGCCCCG CGGCCCGGCT TGCCCG 36 (2) INFORMATION FOR SEQ ID NO:2112: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 35 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2112: GGGCCCCTGG CTCGGCCCCG CGGCCCGGCT TGCCC 35 (2) INFORMATION FOR SEQ ID NO:2113: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 34 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2113: GGGCCCCTGG CTCGGCCCCG CGGCCCGGCT TGCC 34 (2) INFORMATION FOR SEQ ID NO:2114: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 33 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2114: GGGCCCCTGG CTCGGCCCCG CGGCCCGGCT TGC 33 (2) INFORMATION FOR SEQ ID NO:2115: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 32 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2115: GGGCCCCTGG CTCGGCCCCG CGGCCCGGCT TG 32 (2) INFORMATION FOR SEQ ID NO:2116: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 31 base pairs .(B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2116: GGGCCCCTGG CTCGGCCCCG CGGCCCGGCT T 31 (2) INFORMATION FOR SEQ ID NO:2117: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 30 base pairs (B) TYPE: nucleic acid WO 00/09525 PCT/US99/17712 LPI-109 531 (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2117: GGGCCCCTGG CTCGGCCCCG CGGCCCGGCT 30 (2) INFORMATION FOR SEQ ID NO:2118: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 29 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2118: GGGCCCCTGG CTCGGCCCCG CGGCCCGGC 29 (2) INFORMATION FOR SEQ ID NO:2119: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 28 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2119: GGGCCCCTGG CTCGGCCCCG CGGCCCGG 28 (2) INFORMATION FOR SEQ ID NO:2120: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 27 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2120: GGGCCCCTGG CTCGGCCCCG CGGCCCG 27 (2) INFORMATION FOR SEQ ID NO:2121: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 26 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2121: GGGCCCCTGG CTCGGCCCCG CGGCCC 26 (2) INFORMATION FOR SEQ ID NO:2122: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 25 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2122: GGGCCCCTGG CTCGGCCCCG CGGCC 25 (2) INFORMATION FOR SEQ ID NO:2123: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 24 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2123: GGGCCCCTGG CTCGGCCCCG CGGC 24 (2) INFORMATION FOR SEQ ID NO:2124: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 23 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2124: GGGCCCCTGG CTCGGCCCCG CGG 23 (2) INFORMATION FOR SEQ ID NO:2125: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2125: WO 00/09525 PCT/US99/17712 EPI-109 532 GGGCCCCTGG CTCGGCCCCG CG 22 (2) INFORMATION FOR SEQ ID NO:2126: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 21 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2126: GGGCCCCTGG CTCGGCCCCG C 21 (2) INFORMATION FOR SEQ ID NO:2127: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 20 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2127: GGGCCCCTGG CTCGGCCCCG 20 (2) INFORMATION FOR SEQ ID NO:2128: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2128: GGGCCCCTGG CTCGGCCCC 19 (2) INFORMATION FOR SEQ ID NO:2129: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2129: GGGCCCCTGG CTCGGCCC 18 (2) INFORMATION FOR SEQ ID NO:2130: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 17 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2130: GGGCCCCTGG CTCGGCC 17 (2) INFORMATION FOR SEQ ID NO:2131: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 16 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2131: GGGCCCCTGG CTCGGC 16 (2) INFORMATION FOR SEQ ID NO:2132: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2132: GGGCCCCTGG CTCGG 15 (2) INFORMATION FOR SEQ ID NO:2133: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2133: GGGCCCCTGG CTCG 14 (2) INFORMATION FOR SEQ ID NO:2134: WO 00/09525 PCT/US99/17712 EPI-109 533 (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 13 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2134: GGGCCCCTGG CTC 13 (2) INFORMATION FOR SEQ ID NO:2135: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 12 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2135: GGGCCCCTGG CT 12 (2) INFORMATION FOR SEQ ID NO:2136: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 45 base pairs (3) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2136: GGCCCCTGGC TCGGCCCCGC GGCCCGGCTT GCCCGCCCGG CCCGG 45 (2) INFORMATION FOR SEQ ID NO:2137: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 44 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2137: GCCCCTGGCT CGGCCCCGCG GCCCGGCTTG CCCGCCCGGC CCGG 44 (2) INFORMATION FOR SEQ ID NO:2138: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 43 base pairs (H) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2138: CCCCTGGCTC GGCCCCGCGG CCCGGCTTGC CCGCCCGGCC CGG 43 (2) INFORMATION FOR SEQ ID NO:2139: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 42 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2139: CCCTGGCTCG GCCCCGCGGC CCGGCTTGCC CGCCCGGCCC GG 42 (2) INFORMATION FOR SEQ ID NO:2140: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 41 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2140: CCTGGCTCGG CCCCGCGGCC CGGCTTGCCC GCCCGGCCCG G 41 (2) INFORMATION FOR SEQ ID NO:2141: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 40 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2141: CTGGCTCGGC CCCGCGGCCC GGCTTGCCCG CCCGGCCCGG 40 (2) INFORMATION FOR SEQ ID NO:2142: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 39 base pairs (H) TYPE: nucleic acid WO 00/09525 PCT/US99/17712 Ik-1 U9 534 (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2142: TGGCTCGGCC CCGCGGCCCG GCTTGCCCGC CCGGCCCGG 39 (2) INFORMATION FOR SEQ ID NO:2143: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 38 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2143: GGCTCGGCCC CGCGGCCCGG CTTGCCCGCC CGGCCCGG 38 (2) INFORMATION FOR SEQ ID NO:2144: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 37 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2144: GCTCGGCCCC GCGGCCCGGC TTGCCCGCCC GGCCCGG 37 (2) INFORMATION FOR SEQ ID NO:2145: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 36 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2145: CTCGGCCCCG CGGCCCGGCT TGCCCGCCCG GCCCGG 36 (2) INFORMATION FOR SEQ ID NO:2146: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 35 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2146: TCGGCCCCGC GGCCCGGCTT GCCCGCCCGG CCCGG 35 (2) INFORMATION FOR SEQ ID NO:2147: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 34 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2147: CGGCCCCGCG GCCCGGCTTG CCCGCCCGGC CCGG 34 (2) INFORMATION FOR SEQ ID NO:2148: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 33 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2148: GGCCCCGCGG CCCGGCTTGC CCGCCCGGCC CGG 33 (2) INFORMATION FOR SEQ ID NO:2149: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 32 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2149: GCCCCGCGGC CCGGCTTGCC CGCCCGGCCC GG 32 (2) INFORMATION FOR SEQ ID NO:2150: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 31 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2150: WO 00/09525 PCT/US99/17712 EPI-109 535 CCCCGCGGCC CGGCTTGCCC GCCCGGCCCG G 31 (2) INFORMATION FOR SEQ ID NO:2151: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 30 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2151: CCCGCGGCCC GGCTTGCCCG CCCGGCCCGG 30 (2) INFORMATION FOR SEQ ID NO:2152: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 29 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2152: CCGCGGCCCG GCTTGCCCGC CCGGCCCGG 29 (2) INFORMATION FOR SEQ ID NO:2153: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 28 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2153: CGCGGCCCGG CTTGCCCGCC CGGCCCGG 28 (2) INFORMATION FOR SEQ ID NO:2154: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 27 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2154: GCGGCCCGGC TTGCCCGCCC GGCCCGG 27 (2) INFORMATION FOR SEQ ID NO:2155: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 26 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2155: CGGCCCGGCT TGCCCGCCCG GCCCGG 26 (2) INFORMATION FOR SEQ ID NO:2156: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 25 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2156: GGCCCGGCTT GCCCGCCCGG CCCGG 25 (2) INFORMATION FOR SEQ ID NO:2157: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 24 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2157: GCCCGGCTTG CCCGCCCGGC CCGG 24 . (2) INFORMATION FOR SEQ ID NO:2158: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 23 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2158: CCCGGCTTGC CCGCCCGGCC CGG 23 (2) INFORMATION FOR SEQ ID NO:2159: WO 00/09525 PCT/US99/17712 EPI-109 536 (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2159: CCGGCTTGCC CGCCCGGCCC GG 22 (2) INFORMATION FOR SEQ ID NO:2160: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 21 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2160: CGGCTTGCCC GCCCGGCCCG G 21 (2) INFORMATION FOR SEQ ID NO:2161: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 20 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2161: GGCTTGCCCG CCCGGCCCGG 20 (2) INFORMATION FOR SEQ ID NO:2162: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2162: GCTTGCCCGC CCGGCCCGG 19 (2) INFORMATION FOR SEQ ID NO:2163: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2163: CTTGCCCGCC CGGCCCGG 18 (2) INFORMATION FOR SEQ ID NO:2164: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 17 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2164: TTGCCCGCCC GGCCCGG 17 (2) INFORMATION FOR SEQ ID NO:2165: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 16 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2165: TGCCCGCCCG GCCCGG 16 (2) INFORMATION FOR SEQ ID NO:2166: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2166: GCCCGCCCGG CCCGG 15 (2) INFORMATION FOR SEQ ID NO:2167: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid WO 00/09525 PCTIUS99/17712 537 (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2167: CCCGCCCGGC CCGG 14 (2) INFORMATION FOR SEQ ID NO:2168: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 13 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2168: CCGCCCGGCC CGG 13 (2) INFORMATION FOR SEQ ID NO:2169: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 12 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2169: CGCCCGGCCC GG 12 (2) INFORMATION FOR SEQ ID NO:2170: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 11 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2170: GCCCGGCCCG G 11 (2) INFORMATION FOR SEQ ID NO:2171: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 36 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2171: GGCGGGGGCG GCGGCGCCTG GCTCGCCTBG GGCCCC 36 (2) INFORMATION FOR SEQ ID NO:2172: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 35 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2172: GGCGGGGGCG GCGGCGCCTG GCTCGCCTBG GGCCC 35 (2) INFORMATION FOR SEQ ID NO:2173: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 34 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2173: GGCGGGGGCG GCGGCGCCTG GCTCGCCTBG GGCC 34 (2) INFORMATION FOR SEQ ID NO:2174: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 33 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2174: GGCGGGGGCG GCGGCGCCTG GCTCGCCTBG GGC 33 (2) INFORMATION FOR SEQ ID NO:2175: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 32 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2175: WO 00/09525 PCTIUS99/17712 cr-Uv 538 GGCGGGGGCG GCGGCGCCTG GCTCGCCTBG GG 32 (2) INFORMATION FOR SEQ ID NO:2176: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 31 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2176: GGCGGGGGCG GCGGCGCCTG GCTCGCCTBG G 31 (2) INFORMATION FOR SEQ ID NO:2177: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 30 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2177: GGCGGGGGCG GCGGCGCCTG GCTCGCCTBG 30 (2) INFORMATION FOR SEQ ID NO:2178: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 29 base pairs (3) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2178: GGCGGGGGCG GCGGCGCCTG GCTCGCCTB 29 (2) INFORMATION FOR SEQ ID NO:2179: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 28 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2179: GGCGGGGGCG GCGGCGCCTG GCTCGCCT 28 (2) INFORMATION FOR SEQ ID NO:2180: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 27 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2180: GGCGGGGGCG GCGGCGCCTG GCTCGCC 27 (2) INFORMATION FOR SEQ ID NO:2181: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 26 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2181: GGCGGGGGCG GCGGCGCCTG GCTCGC 26 (2) INFORMATION FOR SEQ ID NO:2182: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 25 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2182: GGCGGGGGCG GCGGCGCCTG GCTCG 25 . (2) INFORMATION FOR SEQ ID NO:2183: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 24 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2183: GGCGGGGGCG GCGGCGCCTG GCTC 24 (2) INFORMATION FOR SEQ ID NO:2184: WO 00/09525 PCT/US99/17712 EPI-109 539 (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 23 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2184: GGCGGGGGCG GCGGCGCCTG GCT 23 (2) INFORMATION FOR SEQ ID NO:2185: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2185: GGCGGGGGCG GCGGCGCCTG GC 22 (2) INFORMATION FOR SEQ ID NO:2186: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 21 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2186: GGCGGGGGCG GCGGCGCCTG G 21 (2) INFORMATION FOR SEQ ID NO:2187: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 20 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2187: GGCGGGGGCG GCGGCGCCTG 20 (2) INFORMATION FOR SEQ ID NO:2188: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2188: GGCGGGGGCG GCGGCGCCT 19 (2) INFORMATION FOR SEQ ID NO:2189: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2189: GGCGGGGGCG GCGGCGCC 18 (2) INFORMATION FOR SEQ ID NO:2190: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 17 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2190: GGCGGGGGCG GCGGCGC 17 (2) INFORMATION FOR SEQ ID NO:2191: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 16 base pairs .(B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2191: GGCGGGGGCG GCGGCG 16 (2) INFORMATION FOR SEQ ID NO:2192: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid WO 00/09525 PCT/US99/17712 Lri-1u9 540 (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2192: GGCGGGGGCG GCGGC 15 (2) INFORMATION FOR SEQ ID NO:2193: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2193: GGCGGGGGCG GCGG 14 (2) INFORMATION FOR SEQ ID NO:2194: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 13 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2194: GGCGGGGGCG GCG 13 (2) INFORMATION FOR SEQ ID NO:2195: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 12 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2195: GGCGGGGGCG GC 12 (2) INFORMATION FOR SEQ ID NO:2196: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 11 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2196: GGCGGGGGCG G 11 (2) INFORMATION FOR SEQ ID NO:2197: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 35 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2197: GCGGGGGCGG CGGCGCCTGG CTCGCCTBGG GCCCC 35 (2) INFORMATION FOR SEQ ID NO:2198: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 34 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2198: CGGGGGCGGC GGCGCCTGGC TCGCCTBGGG CCCC 34 (2) INFORMATION FOR SEQ ID NO:2199: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 33 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2199: GGGGGCGGCG GCGCCTGGCT CGCCTBGGGC CCC 33 (2) INFORMATION FOR SEQ ID NO:2200: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 32 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2200: WO 00/09525 PCT/US99/17712 EPI-109 541 GGGGCGGCGG CGCCTGGCTC GCCTBGGGCC CC 32 (2) INFORMATION FOR SEQ ID NO:2201: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 31 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2201: GGGCGGCGGC GCCTGGCTCG CCTBGGGCCC C 31 (2) INFORMATION FOR SEQ ID NO:2202: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 30 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2202: GGCGGCGGCG CCTGGCTCGC CTBGGGCCCC 30 (2) INFORMATION FOR SEQ ID NO:2203: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 29 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2203: GCGGCGGCGC CTGGCTCGCC TBGGGCCCC 29 (2) INFORMATION FOR SEQ ID NO:2204: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 28 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2204: CGGCGGCGCC TGGCTCGCCT BGGGCCCC 28 (2) INFORMATION FOR SEQ ID NO:2205: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 27 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2205: GGCGGCGCCT GGCTCGCCTB GGGCCCC 27 (2) INFORMATION FOR SEQ ID NO:2206: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 26 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2206: GCGGCGCCTG GCTCGCCTBG GGCCCC 26 (2) INFORMATION FOR SEQ ID NO:2207: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 25 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2207: CGGCGCCTGG CTCGCCTBGG GCCCC 25 (2) INFORMATION FOR SEQ ID NO:2208: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 24 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2208: GGCGCCTGGC TCGCCTBGGG CCCC 24 (2) INFORMATION FOR SEQ ID NO:2209: WO 00/09525 PCT/US99/17712 EPI-109 542 (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 23 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2209: GCGCCTGGCT CGCCTBGGGC CCC 23 (2) INFORMATION FOR SEQ ID NO:2210: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 base pairs (H) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2210: CGCCTGGCTC GCCTBGGGCC CC 22 (2) INFORMATION FOR SEQ ID NO:2211: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 21 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2211: GCCTGGCTCG CCTBGGGCCC C 21 (2) INFORMATION FOR SEQ ID NO:2212: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 20 base pairs (3) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2212: CCTGGCTCGC CTBGGGCCCC 20 (2) INFORMATION FOR SEQ ID NO:2213: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2213: CTGGCTCGCC TBGGGCCCC 19 (2) INFORMATION FOR SEQ ID NO:2214: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (H) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2214: TGGCTCGCCT BGGGCCCC 18 (2) INFORMATION FOR SEQ ID NO:2215: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 17 base pairs (H) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2215: GGCTCGCCTB GGGCCCC 17 (2) INFORMATION FOR SEQ ID NO:2216: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 16 base pairs .(H) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2216: GCTCGCCTBG GGCCCC 16 (2) INFORMATION FOR SEQ ID NO:2217: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (H) TYPE: nucleic acid WO 00/09525 PCTIUS99/17712 EPI-109 543 (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2217: CTCGCCTBGG GCCCC 15 (2) INFORMATION FOR SEQ ID NO:2218: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2218: TCGCCTBGGG CCCC 14 (2) INFORMATION FOR SEQ ID NO:2219: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 13 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2219: CGCCTBGGGC CCC 13 (2) INFORMATION FOR SEQ ID NO:2220: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 12 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2220: GCCTBGGGCC CC 12 (2) INFORMATION FOR SEQ ID NO:2221: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 11 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2221: CCTBGGGCCC C 11 (2) INFORMATION FOR SEQ ID NO:2222: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 10 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2222: CTBGGGCCCC 10 (2) INFORMATION FOR SEQ ID NO:2223: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 17 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2223: GGGTGGGCBC GGCGGCC 17 (2) INFORMATION FOR SEQ ID NO:2224: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 24 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2224: GGTCGGCGBB GBGCTCGTCG TGGC 24 (2) INFORMATION FOR SEQ ID NO:2225: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 23 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2225: WO 00/09525 PCTIUS99/17712 EPI-109 544 GGTCGGCGBB GBGCTCGTCG TGG 23 (2) INFORMATION FOR SEQ ID NO:2226: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2226: GGTCGGCGBB GBGCTCGTCG TG 22 (2) INFORMATION FOR SEQ ID NO:2227: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 21 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2227: GGTCGGCGBB GBGCTCGTCG T 21 (2) INFORMATION FOR SEQ ID NO:2228: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 20 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2228: GGTCGGCGBB GBGCTCGTCG 20 (2) INFORMATION FOR SEQ ID NO:2229: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2229: GGTCGGCGBB GBGCTCGTC 19 (2) INFORMATION FOR SEQ ID NO:2230: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2230: GGTCGGCGBB GBGCTCGT 18 (2) INFORMATION FOR SEQ ID NO:2231: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 17 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2231: GGTCGGCGBB GBGCTCG 17 (2) INFORMATION FOR SEQ ID NO:2232: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 16 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2232: GGTCGGCGBB GBGCTC 16 (2) INFORMATION FOR SEQ ID NO:2233: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2233: GGTCGGCGBB GBGCT 15 (2) INFORMATION FOR SEQ ID NO:2234: WO 00/09525 PCT/US99/17712 EPI-109 545 (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2234: GGTCGGCGBB GBGC 14 (2) INFORMATION FOR SEQ ID NO:2235: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 13 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2235: GGTCGGCGBB GBG 13 (2) INFORMATION FOR SEQ ID NO:2236: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 12 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2236: GGTCGGCGBB GB 12 (2) INFORMATION FOR SEQ ID NO:2237: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 11 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2237: GGTCGGCGBB G 11 (2) INFORMATION FOR SEQ ID NO:2238: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 23 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2238: GTCGGCGBBG BGCTCGTCGT GGC 23 (2) INFORMATION FOR SEQ ID NO:2239: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2239: TCGGCGBBGB GCTCGTCGTG GC 22 (2) INFORMATION FOR SEQ ID NO:2240: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 21 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2240: CGGCGBBGBG CTCGTCGTGG C 21 (2) INFORMATION FOR SEQ ID NO:2241: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 20 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2241: GGCGBBGBGC TCGTCGTGGC 20 (2) INFORMATION FOR SEQ ID NO:2242: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 base pairs (B) TYPE: nucleic acid WO 00/09525 PCTIUS99/17712 EPI-109 546 (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2242: GCGBBGBGCT CGTCGTGGC 19 (2) INFORMATION FOR SEQ ID NO:2243: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2243: CGBBGBGCTC GTCGTGGC 18 (2) INFORMATION FOR SEQ ID NO:2244: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 17 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2244: GBBGBGCTCG TCGTGGC 17 (2) INFORMATION FOR SEQ ID NO:2245: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 16 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2245: BBGBGCTCGT CGTGGC 16 (2) INFORMATION FOR SEQ ID NO:2246: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2246: BGBGCTCGTC GTGGC 15 (2) INFORMATION FOR SEQ ID NO:2247: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2247: GBGCTCGTCG TGGC 14 (2) INFORMATION FOR SEQ ID NO:2248: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 13 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2248: BGCTCGTCGT GGC 13 (2) INFORMATION FOR SEQ ID NO:2249: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 12 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2249: GCTCGTCGTG GC 12 (2) INFORMATION FOR SEQ ID NO:2250: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 11 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2250: WO 00/09525 PCTIUS99/17712 EPI-109 547 CTCGTCGTGG C 11 (2) INFORMATION FOR SEQ ID NO:2251: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 10 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2251: TCGTCGTGGC 10 (2) INFORMATION FOR SEQ ID NO:2252: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 20 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2252: GGGGCCCCGC GCCGCCCGCC 20 (2) INFORMATION FOR SEQ ID NO:2253: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2253: GGGGCCCCGC GCCGCCCGC 19 (2) INFORMATION FOR SEQ ID NO:2254: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2254: GGGGCCCCGC GCCGCCCG 18 (2) INFORMATION FOR SEQ ID NO:2255: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 17 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2255: GGGGCCCCGC GCCGCCC 17 (2) INFORMATION FOR SEQ ID NO:2256: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 16 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2256: GGGGCCCCGC GCCGCC 16 (2) INFORMATION FOR SEQ ID NO:2257: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2257: GGGGCCCCGC GCCGC 15 (2) INFORMATION FOR SEQ ID NO:2258: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2258: GGGGCCCCGC GCCG 14 (2) INFORMATION FOR SEQ ID NO:2259: WO 00/09525 PCT/US99/17712 EPI-109 548 (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 13 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2259: GGGGCCCCGC GCC 13 (2) INFORMATION FOR SEQ ID NO:2260: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 12 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2260: GGGGCCCCGC GC 12 (2) INFORMATION FOR SEQ ID NO:2261: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2261: GGGCCCCGCG CCGCCCGCC 19 (2) INFORMATION FOR SEQ ID NO:2262: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2262: GGCCCCGCGC CGCCCGCC 18 (2) INFORMATION FOR SEQ ID NO:2263: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 17 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2263: GCCCCGCGCC GCCCGCC 17 (2) INFORMATION FOR SEQ ID NO:2264: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 16 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2264: CCCCGCGCCG CCCGCC 16 (2) INFORMATION FOR SEQ ID NO:2265: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2265: CCCGCGCCGC CCGCC 15 (2) INFORMATION FOR SEQ ID NO:2266: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2266: CCGCGCCGCC CGCC 14 (2) INFORMATION FOR SEQ ID NO:2267: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 13 base pairs (B) TYPE: nucleic acid WO 00/09525 PCT/US99/17712 EPI-109 549 (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2267: CGCGCCGCCC GCC 13 (2) INFORMATION FOR SEQ ID NO:2268: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 12 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2268: GCGCCGCCCG CC 12 (2) INFORMATION FOR SEQ ID NO:2269: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 11 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2269: CGCCGCCCGC C 11 (2) INFORMATION FOR SEQ ID NO:2270: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 10 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2270: GCCGCCCGCC 10 (2) INFORMATION FOR SEQ ID NO:2271: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 21 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2271: GGGGCGCGCG GGGCCGCCGG G 21 (2) INFORMATION FOR SEQ ID NO:2272: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 26 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2272: GGCGGGGBGC GGCBGGGCCC GGGCCC 26 (2) INFORMATION FOR SEQ ID NO:2273: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 33 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2273: GGCGCGTCGC CGTCGCCCCB GTCGGGCTCG CGC 33 (2) INFORMATION FOR SEQ ID NO:2274: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 26 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2274: GCGCGGGCBB CBGCGBGCCG GGCGCG 26 (2) INFORMATION FOR SEQ ID NO:2275: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 24 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2275: WO 00/09525 PCTIUS99/17712 EPI-109 550 GCGCBCGGGC CCBCCTGCGC GGGC 24 (2) INFORMATION FOR SEQ ID NO:2276: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 28 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2276: GGGCGGGGTG GGCTGCCCTG CGGCCGCC 28 (2) INFORMATION FOR SEQ ID NO:2277: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 26 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2277: GGGCTGCTGC GCGGCGGCTC CGGCGA 26 (2) INFORMATION FOR SEQ ID NO:2278: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 25 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2278: CTCCCGGGCG GGGCCGGGCG CGGGG 25 (2) INFORMATION FOR SEQ ID NO:2279: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 33 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2279: GGGCTGCCGC GGTCCGGGCC CCTCTTGCCG GCG 33 (2) INFORMATION FOR SEQ ID NO:2280: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2280: GCGCTCGCGC CGCTGCCGG 19 (2) INFORMATION FOR SEQ ID NO:2281: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 23 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2281: GCGCCGCTTG GCCTTGTCGC GGC 23 (2) INFORMATION FOR SEQ ID NO:2282: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 17 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2282: GCTGCTCCBC GCGCTGG 17 (2) INFORMATION FOR SEQ ID NO:2283: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 24 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2283: GCCGGBGGCC GGCCBGGTCC CGCG 24 (2) INFORMATION FOR SEQ ID NO:2284: WO 00/09525 PCT/US99/17712 EPI-109 551 (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 31 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2284: CCCGGCGGCC GGCBGGBBGG GCGGGCTGGG C 31 (2) INFORMATION FOR SEQ ID NO:2285: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 23 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2285: GTCTCTCCCG CCCCGGCCGC GCG 23 (2) INFORMATION FOR SEQ ID NO:2286: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 24 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2286: GGGCGTCCGC TCCGGGCCGT CGGG 24 (2) INFORMATION FOR SEQ ID NO:2287: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 28 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2287: GCGGGCACGC GGCGGCTCTG GCGTCGGC 28 (2) INFORMATION FOR SEQ ID NO:2288: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 681 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2288: GGTGBCBTTG BGCBTGTCGG CGCGGTCCCG TTBBGBGTGG GCCCGCCAGC CCAGCCACTC 60 CACTTGGGGG CGGGTGGCCA GCACGAACAG CACCCAGAGG AAGGGGGGCG GCCCAGAAGG 120 GCAGCCCGCA GGCCAGGATC AGGTCTGCTG CGGCCGGAGA TAATGGCATT CACCACGCGG 180 CGGCCCAGCG CACGCCGCGC ATCCGGCCCG GGTTCTGACC TGCAGCCCCC GTCTCCTTGG 240 CATTCCTGGG CCCCAGTCAC TCCTCTCCCT GCCCCCCTTG CTGGGGCAGG GACGGGGTGB 300 CBTTGBGCBT GTCGGCGCGG TCCCGTTBBG BGTGGGCCCG CCAGCCCAGC CACTCCACTT 360 GGGGGCGGGT GGCCAGCACG AACAGCACCC AGAGGAAGGG GGGCGGCCCA GAAGGGCAGC 420 CCGCAGGCCA GGATCAGGTC TGCTGCGGCC GGAGATAATG GCATTCACCA CGCGGCGGCC 480 CAGCGCACGC CGCGCATCCG GCCCGGGTTC TGACCTGCAG CCCCCGTCTC CTTGGCATTC 540 CTGGGCCCCA GTCACTCCTC TCCCTGCCCC CCTTGCTGGG GCAGGGACGG CCGTGTTGTC 600 BGTGGTGCTG CCCGTTTGBG GTBTGGCGCT CCBCCBBTTC CCTTTTCTCC TTGTTTTCCG 660 TTTCTCTTGC CGTCTGTGGT T 681 (2) INFORMATION FOR SEQ ID NO:2289: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 23 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2289: GGTGBCBTTG BGCBTGTCGG CGC 23 (2) INFORMATION FOR SEQ ID NO:2290: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 21 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2290: GGTCCCGTTB BGBGTGGGCC C 21 (2) INFORMATION FOR SEQ ID NO:2291: (i) SEQUENCE CHARACTERISTICS: WO 00/09525 PCT/US99/17712 EPI-109 552 (A) LENGTH: 27 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2291: GCCAGCCCAG CCACTCCACT TGGGGGC 27 (2) INFORMATION FOR SEQ ID NO:2292: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 38 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2292: GGGTGGCCAG CACGAACAGC ACCCAGAGGA AGGGGGGC 38 (2) INFORMATION FOR SEQ ID NO:2293: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 46 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2293: GGCCCAGAAG GGCAGCCCGC AGGCCAGGAT CAGGTCTGCT GCGGCC 46 (2) INFORMATION FOR SEQ ID NO:2294: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 26 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2294: GGAGATAATG GCATTCACCA CGCGGC 26 (2) INFORMATION FOR SEQ ID NO:2295: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 28 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2295: GGCCCAGCGC ACGCCGCGCA TCCGGCCC 28 (2) INFORMATION FOR SEQ ID NO:2296: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 21 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2296: GGGTTCTGAC CTGCAGCCCC C 21 (2) INFORMATION FOR SEQ ID NO:2297: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 23 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2297: GTCTCCTTGG CATTCCTGGG CCC 23 (2) INFORMATION FOR SEQ ID NO:2298: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 23 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2298: CAGTCACTCC TCTCCCTGCC CCC 23 (2) INFORMATION FOR SEQ ID NO:2299: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single WO 00/09525 PCT/US99/17712 EPI-109 553 (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2299: CTTGCTGGGG CAGGGACGG 19 (2) INFORMATION FOR SEQ ID NO:2300: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 23 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2300: GGTGBCBTTG BGCBTGTCGG CGC 23 (2) INFORMATION FOR SEQ ID NO:2301: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 21 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2301: GGTCCCGTTB BGBGTGGGCC C 21 (2) INFORMATION FOR SEQ ID NO:2302: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 27 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2302: GCCAGCCCAG CCACTCCACT TGGGGGC 27 (2) INFORMATION FOR SEQ ID NO:2303: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 38 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2303: GGGTGGCCAG CACGAACAGC ACCCAGAGGA AGGGGGGC 38 (2) INFORMATION FOR SEQ ID NO:2304: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 46 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2304: GGCCCAGAAG GGCAGCCCGC AGGCCAGGAT CAGGTCTGCT GCGGCC 46 (2) INFORMATION FOR SEQ ID NO:2305: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 26 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2305: GGAGATAATG GCATTCACCA CGCGGC 26 (2) INFORMATION FOR SEQ ID NO:2306: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 28 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2306: GGCCCAGCGC ACGCCGCGCA TCCGGCCC 28 (2) INFORMATION FOR SEQ ID NO:2307: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 21 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2307: GGGTTCTGAC CTGCAGCCCC C 21 WO 00/09525 PCT/US99/17712 EPI-109 554 (2) INFORMATION FOR SEQ ID NO:2308: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 23 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2308: GTCTCCTTGG CATTCCTGGG CCC 23 (2) INFORMATION FOR SEQ ID NO:2309: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 23 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2309: CAGTCACTCC TCTCCCTGCC CCC 23 (2) INFORMATION FOR SEQ ID NO:2310: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2310: CTTGCTGGGG CAGGGACGG 19 (2) INFORMATION FOR SEQ ID NO:2311: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 20 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2311: CCGTGTTGTC BGTGGTGCTG 20 (2) INFORMATION FOR SEQ ID NO:2312: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 17 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2312: CCCGTTTGBG GTBTGGC 17 (2) INFORMATION FOR SEQ ID NO:2313: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 23 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2313: GCTCCBCCBB TTCCCTTTTC TCC 23 (2) INFORMATION FOR SEQ ID NO:2314: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2314: TTGTTTTCCG TTTCTCTTG 19 (2) INFORMATION FOR SEQ ID NO:2315: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 12 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2315: CCGTCTGTGG TT 12 (2) INFORMATION FOR SEQ ID NO:2316: (i) SEQUENCE CHARACTERISTICS: WO 00/09525 PCT/US99/17712 EPI-109 555 (A) LENGTH: 19 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2316: CCCGGCCCCG CCTCGTGCC 19 (2) INFORMATION FOR SEQ ID NO:2317: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2317: CGTCCBTGCC GCGGGCCC 18 (2) INFORMATION FOR SEQ ID NO:2318: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 28 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2318: GCCCCGCTGC TTGGGCTGCT CTGCCGGG 28 (2) INFORMATION FOR SEQ ID NO:2319: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 21 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2319: TCTGTGCTCC TCTCGCCTGG G 21 (2) INFORMATION FOR SEQ ID NO:2320: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 21 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2320: TGGTGGGGTG GGTCTTGGTG G 21 (2) INFORMATION FOR SEQ ID NO:2321: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 17 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2321: CTGTCCCTGG TCCTGTG 17 (2) INFORMATION FOR SEQ ID NO:2322: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2322: GGTCCCGCTT CTTC 14 (2) INFORMATION FOR SEQ ID NO:2323: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2323: GGGGTTGTTG TTGGTCTGG 19 (2) INFORMATION FOR SEQ ID NO:2324: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single WO 00/09525 PCTIUS99/17712 EPI-109 556 (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2324: TGTCCTCTTT CTGC 14 (2) INFORMATION FOR SEQ ID NO:2325: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2325: GCCTCGGGCC TCCC 14 (2) INFORMATION FOR SEQ ID NO:2326: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2326: GGCTGGGGTC TGCGT 15 (2) INFORMATION FOR SEQ ID NO:2327: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 24 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2327: GGCCGGGGGT CGGTGGGTCC GCTG 24 (2) INFORMATION FOR SEQ ID NO:2328: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear. (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2328: GGGCTGGGGT GCTGGCTTGG GG 22 (2) INFORMATION FOR SEQ ID NO:2329: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2329: GGGGCTGGGG CCTGGGCC 18 (2) INFORMATION FOR SEQ ID NO:2330: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 20 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2330: GCCTGGGTGG GCTTGGGGGC 20 (2) INFORMATION FOR SEQ ID NO:2331: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 20 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2331: GCTGGGTCTG TGCTGTTGCC 20 (2) INFORMATION FOR SEQ ID NO:2332: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2332: GTTGTGTGGG GGGCC 15 WO 00/09525 PCT/US99/17712 EPI-109 557 (2) INFORMATION FOR SEQ ID NO:2333: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 27 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2333: GCTGGGTCGG GGGGCCTCTG GGCTGTC 27 (2) INFORMATION FOR SEQ ID NO:2334: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2334: GCCCCGGGGC CCCC 14 (2) INFORMATION FOR SEQ ID NO:2335: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2335: TGGCTCCCCC CTCC 14 (2) INFORMATION FOR SEQ ID NO:2336: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2336: GCTCCCCCCT TTCC 14 (2) INFORMATION FOR SEQ ID NO:2337: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 16 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2337: CGGACGAAGA CAGAGA 16 (2) INFORMATION FOR SEQ ID NO:2338: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2338: GGCTTTGTGG GCTC 14 (2) INFORMATION FOR SEQ ID NO:2339: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2339: GCCTGCTCTC CCCC 14 (2) INFORMATION FOR SEQ ID NO:2340: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2340: CCCGGCCCCG CCBCGBBCC 19 (2) INFORMATION FOR SEQ ID NO:2341: (i) SEQUENCE CHARACTERISTICS: WO 00/09525 PCT/US99/17712 EPI-109 558 (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2341: CCCGGCCCCG CCBCG 15 (2) INFORMATION FOR SEQ ID NO:2342: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2342: CCCGGCCCCG CCBCGBBCC 19 (2) INFORMATION FOR SEQ ID NO:2343: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2343: CCCGGCCCCG CCBCG 15 (2) INFORMATION FOR SEQ ID NO:2344: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 17 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2344: CCCGBCCCCG CCTCBBG 17 (2) INFORMATION FOR SEQ ID NO:2345: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2345: CCCGBCCCCG CCTC 14 (2) INFORMATION FOR SEQ ID NO:2346: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 13 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2346: CCGGCCCCGC CTC 13 (2) INFORMATION FOR SEQ ID NO:2347: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2347: CCCGBBCCCG CBTBGTGCC 19 (2) INFORMATION FOR SEQ ID NO:2348: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 13 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2348: CCCGCBTBGT GCC 13 (2) INFORMATION FOR SEQ ID NO:2349: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single WO 00/09525 PCT/US99/17712 EPI-109 559 (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2349: CCCGGBCCCB CCBBGTGCC 19 (2) INFORMATION FOR SEQ ID NO:2350: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2350: CBGBBCCCGC CTCGTGCC 18 (2) INFORMATION FOR SEQ ID NO:2351: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 13 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2351: CCCGCCTCGT GCC 13 (2) INFORMATION FOR SEQ ID NO:2352: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2352: CCGGCBCCGC CTCBTGCC 18 (2) INFORMATION FOR SEQ ID NO:2353: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2353: CCGGCCCCGC CBCBTGCC 18 (2) INFORMATION FOR SEQ ID NO:2354: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2354: CCCGBCCCCG BCTCG 15 (2) INFORMATION FOR SEQ ID NO:2355: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2355: CCCGGCCBCG BCTCG 15 (2) INFORMATION FOR SEQ ID NO:2356: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2356: CCCGGCCCBG CCTBG 15 (2) INFORMATION FOR SEQ ID NO:2357: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2357: CCCGGCBCBG BCTCGTBCC 19 WO 00/09525 PCTIUS99/17712 EPI-109 560 (2) INFORMATION FOR SEQ ID NO:2358: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2358: CCCGGCCCCG CCBCG 15 (2) INFORMATION FOR SEQ ID NO:2359: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2359: CCCGGCCCCG CCBCG 15 (2) INFORMATION FOR SEQ ID NO:2360: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2360: TCCBTGCCGC GGGC 14 (2) INFORMATION FOR SEQ ID NO:2361: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2361: TCCBTGCCBC GGGCC 15 (2) INFORMATION FOR SEQ ID NO:2362: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2362: TCCBTGCCBC GGGCC 15 (2) INFORMATION FOR SEQ ID NO:2363: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2363: TCCBTGCCBC BGGCC 15 (2) INFORMATION FOR SEQ ID NO:2364: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 13 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2364: GTCCBTGBCG CGG 13 (2) INFORMATION FOR SEQ ID NO:2365: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 13 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2365: TCCBTGBCGC GGG 13 (2) INFORMATION FOR SEQ ID NO:2366: (i) SEQUENCE CHARACTERISTICS: WO 00/09525 PCT/US99/17712 EPI-109 561 (A) LENGTH: 21 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2366: TCTGBGCTCC TCTBBCCTGG G 21 (2) INFORMATION FOR SEQ ID NO:2367: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 20 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2367: CTGTGCBCCT BBCBCCTGGG 20 (2) INFORMATION FOR SEQ ID NO:2368: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2368: TGTGBTCCBC TBGBCTGGG 19 (2) INFORMATION FOR SEQ ID NO:2369: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2369: TCTGTBCTCB BCTCBCCTG 19 (2) INFORMATION FOR SEQ ID NO:2370: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 17 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2370: TGCTCCTCBC BBCTGGG 17 (2) INFORMATION FOR SEQ ID NO:2371: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2371: CTCCTCTBGC CTGG 14 (2) INFORMATION FOR SEQ ID NO:2372: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2372: GTGCTCCBBT CBBCTGGG 18 (2) INFORMATION FOR SEQ ID NO:2373: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2373: GTGCBCCBBT CBCCTGGG 18 (2) INFORMATION FOR SEQ ID NO:2374: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single WO 00/09525 PCT/US99/17712 EPI-109 562 (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2374: TCTGTGCBCC TCTBGBCT 18 (2) INFORMATION FOR SEQ ID NO:2375: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 16 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2375: TBBTCCTBBC BCCTGG 16 (2) INFORMATION FOR SEQ ID NO:2376: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2376: TGTGCTBBTC BCBCBTGGG 19 (2) INFORMATION FOR SEQ ID NO:2377: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 16 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2377: GTGCBCCBCT CBCCTG 16 (2) INFORMATION FOR SEQ ID NO:2378: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 13 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2378: CTGTGCBCCT CTC 13 (2) INFORMATION FOR SEQ ID NO:2379: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2379: CBGTGCBCCB CTCBCCTG 18 (2) INFORMATION FOR SEQ ID NO:2380: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 16 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2380: GTGCBCCBCT CBCCTG 16 (2) INFORMATION FOR SEQ ID NO:2381: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2381: CBCCTCTCBC CTGGG 15 (2) INFORMATION FOR SEQ ID NO:2382: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 13 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2382: CCTCTCBCCT GGG 13 WO 00/09525 PCT/US99/17712 EPI-109 563 (2) INFORMATION FOR SEQ ID NO:2383: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 13 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2383: GCTCCBCTCG CCT 13 (2) INFORMATION FOR SEQ ID NO:2384: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 13 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2384: TGCTCCTCBC GCC 13 (2) INFORMATION FOR SEQ ID NO:2385: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 13 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2385: GTTGTTGBTC TGG 13 (2) INFORMATION FOR SEQ ID NO:2386: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2386: GGTTGBBBTT GGTCTTGG 18 (2) INFORMATION FOR SEQ ID NO:2387: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 16 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2387: GGTTGTTGBT GBTCTG 16 (2) INFORMATION FOR SEQ ID NO:2388: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2388: GGGTTBBBGT TGBTCTGG 18 (2) INFORMATION FOR SEQ ID NO:2389: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2389: GGGTTBBBGT TGBTCTGG 18 (2) INFORMATION FOR SEQ ID NO:2390: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2390: TTGTTGTBGB TCTGG 15 (2) INFORMATION FOR SEQ ID NO:2391: (i) SEQUENCE CHARACTERISTICS: WO 00/09525 PCT/US99/17712 EPI-109 564 (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2391: GGGTBGBBGB GTCCGCTG 18 (2) INFORMATION FOR SEQ ID NO:2392: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2392: GGGTCBGBGG BTCBGCTG 18 (2) INFORMATION FOR SEQ ID NO:2393: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 13 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2393: GGGTBGGTGG GTC 13 (2) INFORMATION FOR SEQ ID NO:2394: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 16 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2394: GGGTCGGBGG GTCBGC 16 (2) INFORMATION FOR SEQ ID NO:2395: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 13 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2395: CCTGGGTGGG CTT 13 (2) INFORMATION FOR SEQ ID NO:2396: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 13 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2396: GGGTGGGCTT GGG 13 (2) INFORMATION FOR SEQ ID NO:2397: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 16 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2397: CCTGGGTGGG BBTGGG 16 (2) INFORMATION FOR SEQ ID NO:2398: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 16 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2398: CCTGGBTGGG CBTGGG 16 (2) INFORMATION FOR SEQ ID NO:2399: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 17 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single WO 00/09525 PCT/US99/17712 EPI-109 565 (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2399: GCCTGBGTGB BCTTGGG 17 (2) INFORMATION FOR SEQ ID NO:2400: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 17 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2400: CCCAVGVCCV CCCAGGC 17 (2) INFORMATION FOR SEQ ID NO:2401: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 13 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2401: AGCCCACCCA GGC 13 (2) INFORMATION FOR SEQ ID NO:2402: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2402: BCCTGGGTGG GCTB 14 (2) INFORMATION FOR SEQ ID NO:2403: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 12 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2403: GGTGGGCTTG GG 12 (2) INFORMATION FOR SEQ ID NO:2404: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 16 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2404: CCBBGGTGGG CTTGGG 16 (2) INFORMATION FOR SEQ ID NO:2405: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2405: CTGGGTGGGB BTGGG 15 (2) INFORMATION FOR SEQ ID NO:2406: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2406: CCBGGGTGGG CTTGG 15 (2) INFORMATION FOR SEQ ID NO:2407: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 12 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2407: GGGTGGGCTT GG 12 WO 00/09525 PCT/US99/17712 EPI-109 566 (2) INFORMATION FOR SEQ ID NO:2408: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 16 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2408: CCTGBGTGBG CBTGGG 16 (2) INFORMATION FOR SEQ ID NO:2409: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 7800 base- pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2409: GGCGGCCTGG AAAGCTGAGA TGGAGGGCGG CATGGCGGGC ACAGGCTGGG CTGCTTTTCT 60 TTTCTGGGCC TCTGTGGTCT GTTTTTTTCT GGCCCTGCTG GGGCGCTCTC CGCCGCCCGC 120 CTGGCTCCCG GBGCCCBTGB TGGGCBTGCC GTGGTTCTTG CCCTCCTTTG GCTGCCGTGC 180 CCGCTCCCCG GCCTCCTGGC GGGTGGCCGT TGGGCCCGTG TTCCCCTGGG GCCTGGGGCT 240 CCCTTCTCTC GCCCTTCTTG CTGGGCCTCT GCTGCTGCTG GTGCTGTGGC CCCCGTACAC 300 CGAGGAGCCC ATGATGGGCA TGCCACAGAC GACAGGCGTB CBCCGBGGBG CCCBTGBTGG 360 GCBTGCCBCB GBCGBCBGGC GGCGCCGTGC CGCGTCTTGG TGGCGGCGGG TTCGCGCCCG 420 CGCGGGGCCC CTCCGGTCCG TTCGCGCCCG CGCGGGGCCC CTCCGGTCCC GGGTCGGGGC 480 CCCCCGCGGC CGCCTCGGGG CTGGGGCGCT GGTGGCCGGG CCGCGCCTCC GCCTGCCGCT 540 TCTGGCTGGG CCCCGGGCGC CCCCTCCCCT CTTGCTCGGG TCCCCGTGAC AGCGCGTCCT 600 GTGTCTCCAG CAGCATGGCC GGGCCAGCTG GGCCCCBCBG CGCGTCCTGT GTCTCCBGCB 660 GCBTGGCCGG GCCBGCTGGG CCCCACAGAG CAGTGCTGTT GTTGGGCATC TTGCCTTCCC 720 AGGGBCBGBG CBTGCTGTTG TTGGGCBTCT TGCCTTCCCB GGGCCCTTTT CTGGTGGGGT 780 GGTGCTGTTG TTGGGCTTTC TTCTGTTCCC BCBGBGCBGT GCTGTTGTTG GGCBTCTTGC 840 CTTCCCBGGG CCCTTTTCTG GTGGGGTGGT GCTGTTGTTG GGCTTTCTTC TGTTCCCTTT 900 CCCCTGGGTC TTCCCTCCTG CTCTTTTTTC ATTTGCTCTC CTATTACTTT CTGTGTCCAT 960 TTTTTCATTA ACCGAGCTGT BTTTGCTCTC CTBTTBCTTT CTGTGTCCBT TTTTTCBTTB 1020 BCCGBGCTGT GCCTGTGTCT GTCCTCCTGC TTCGTTCCTC TCGTTCCTGC TTGGTGCCCT 1080 TGCCGGTCCT GCTCCTCCGG GCTGTGGGTC GTGGCCCTGG CTCCGGCTGG TGGGCTCCCC 1140 TGGCCTTCGC TGGCTGGCGG CGTGCGGGTC TTGCTCTGGG CCTGGCTGTG GCCGTGGTTG 1200 GGGGTCTTCG CTGCCTCCGT TTGGGTGGCT CTCTGAATAT TGACCTTCCT CCATGGCGGT 1260 CCTGCTTGGA TTCTCCCGAT CTCTGBBTBT TGBCCTTCCT CCBTGGCGGT CCTGCTTGGB 1320 TTCTCCCGBG CCTTTCCTGG TTCTCTTGTT GTTTTTGGGG TTTGGCTTAC AGTAGAGTAG 1380 GGGATTCCAT GGCAGGAGCC ATCTTCTTCA TGGACTCCTT CAAGGAGACC TTAGGTTTCT 1440 GAGGGACTGC TAACACGCCA TCTGGAGCBC BGTBGBGTBG GGGBTTCCBT GGCBGGBGCC 1500 BTCTTCTTCB TGGBCTCCTT CBBGGBGBCC TTBGGTTTCT GBGGGBCTGC TBBCBCGCCB 1560 TCTGGBGCGT TGTTTTTGGG GTTTGGCTTG CCTTTCCTGG TTCTCTTBCB GTBGBGTBGG 1620 GGBTTCCBTG GCBGGBGCCB TCTTCTTCBT GGBCTCCTTC BBGGBGBCCT TBGGTTTCTG 1680 BGGGBCTGCT BBCBCGCCBT CTGGBGCGCC TGTGTCTGTC CTCCTGCTTC GTTCCTCTCG 1740 TTCCTGCTTG GTGCCCTTGC CGGTCCTGCT CCTCCGGGCT GTGGGTCCTC GCCCTGGCTC 1800 CGGCTGGTGG GCTCCCCTGG CCTTCGCTGG CTGGCGGCGT GCCCCBGBBC GBGBCCCGGB 1860 CCGBCBGGCC GTGGTTGGGG GTCTTCGCTG CCTCCGTTTG GGTGGCGATC TCTGAATATT 1920 GACCTTCCAT GGCGGTCCTG CTTGGAGBTC TCTGBBTBTT GBCCTTCCBT GGCGGTCCTG 1980 CTTGGBTCTG GGGTGTCCTG GCCTTCGTGG TTCCTCTTCC TTCGTTTGCC GTCCGCGGGG 2040 GCCCCCGGGC CTGGCTGCGC TCCTGCCCCG CCTCTTTCCC GGGCTCTTGC GCTGGGGGGT 2100 GCTCCCGTGT GTTTGCGCCC TCCTCCTGGT CGCGCTTGTC GTTTTGGGGC CGGCTTTGCC 2160 CGCCTCCCGG CGCCTGGCCC GGCCTTCCTG GGCTGCGTGC GCGTTCTGTT CTTCTTCCTG 2220 GCTCTGGGGT GTCCTGGCCT TCGTGGTTCC TCTTCCTTCG TTTGCCGTCC GCGGGGGCCC 2280 CCGGGCCTGG CTGCGCTCCT GCCCCGCCTC TTTCCCGGGC TCTTGCGCTG GGGGGTGCTC 2340 CCGTGTGTTT GCGCCCTCCT CCTGGTCGCG CTTGTCGTTT TGGGGCCGGC TTTGCCCGCC 2400 TCCCGGCGCC TGGCCCGGCC TTCCTGGGCT GCGTGCGCGT TCTGTTCTTC TTCCTGGCGC 2460 AGGAGACAGG GCAGGGCGAT CAGGAGCAGC GTGAGCCAAA GGAGGACCAT CGGGAACGCA 2520 GCTCCGGAAC GCAGGACAGA GGTGCCGCBG GBGBCBGGGC BGGGCGBTCB GGBGCBGCGT 2580 GBGCCBBBGG BGGBCCBTCG GGBBCGCBGC TCCGGBBCGC BGGBCBGBGG TGCCTCTGCC 2640 CTGTCCGCCG GCTCTTCGGT GGCTCGGCCC CGCTCCTTGT CTTGCCGCGG GTTGGTTCCT 2700 GGGCCTGGTT CTTGCGGGCG TTTCGGTCTG CTGGCTGGTC TGGGCCCGCG GTGCGGCGGG 2760 TGGCTTGCTG TTCTGCCTGG GCTCTCCCCT CTCCTCCTTT TCTCCCTTCC TCTGTCTTGC 2820 CTCCTTCCTC TGGGTCCTCT TGGCCTGGGC GCTCTTCCCC TCGGGCGGCT GCGGGCGCTC 2880 GTGCTGCCTG GTCCGCTCCC TGGGGGTGCT CCTTCCCTTT CCCCGCTCGT GGGGTTTGCG 2940 GGGCTGGGCT GCCCTGGGGG GTCTGGGCCT TTTGGGGTCG GCTGGCTGCT GCTTCGGGCC 3000 GCCTGGGCTT CCCTGTGCCC CTTTCCTCTG CTGGGTCCCC CTCCCGTTCC AAGCTGCACC 3060 GCACAGACCG GCGCTACAGG ACAGAGCCAG GCAAGCACCC ATGGGGATCC AGGCCCAGCT 3120 GTTCCBBGCT GCBCCGCBCB GBCCGGCGCT BCBGGBCBGB GCCBGGCBBG CBCCCBTGGG 3180 GBTCCBGGCC CBGCTGCTCA GTGGCCCCCA AAAGGATGAG TAATACATGC GCCACGATGA 3240 TCATATCCTT TTTACTATGA GGCCGTGTCT GTCGTGTCTT TCCTTTGCTC TTGGTGTGTC 3300 TTTGCTGTGC CCTGCCTCTC TGCCCGTGTC TGTCGTGTCT TTCCTTTGCT CTTGGTGTGT 3360 CTTTGCTGTG CCCTGCCTCT CTGCCCGTGT CTGTCGTGTC TTTCCTTTGC TCTTGGTGTG 3420 TCTTTGCTGT GCCCTGCCTC TCTGCGGGGG TGGCTTCCTG CCGCGTCTCT GGGCCGTCCC 3480 WO 00/09525 PCT/US99/17712 EPI-109 567 GTCCCTCGGC CCCGCGCCGC GCTCGGCTCC TCTCCCTCTG GCCCGGCTCG GGGCGGGGCG 3540 GGGCGGTGGG CGGGCGGCGC TGCCCTGCGC GCGGCGCTGG CCCCTGCTGG CCGTCGGCTG 3600 CGCGCTGCTG GCTGCCCTGC TGGCCGCGCC GGGGCCTGTC CGCCTCTGCG GGCGCTGTCT 3660 CCTGGCTTGT CTTCCGGCTC TTCTGCTGGG GTGGGGCTGG GCGGCCGGCC CGGTGCTGGG 3720 GCTCCTCGGG GGGGGGGGCT CTTCCGGGCT GTCTCCCTCC GGGGCGGGGG TTTCTGGCCG 3780 TGGGGGTCTT GCCTGGCCTC CGGGCTCCTG CTTGTCTTGC CTTCCTTCTC TGGTCGGTTG 3840 TGGCTCGGGG CTCCGTGGGT CCCTGGCGCC CGTTTGTGTT TTGTCTTTTC CCCTGGCGTC 3900 CCTGTGCCCC TCTCCTCTCC TTCCTCTGCT TCTCGCTCTC CTTTGTGGGG CCCTCCCTGC 3960 TGCTCTTGGT TTTGGGCTTT TTTTCTCTTC CTCCTTTTTC GTGCGTGGGC CTCCGCACGC 4020 CTCTTGCCAC CTCCTGCGCA GGGCAGCGCC TTGGGGCCAG CGCCGCTCCC GGCGCGGCCA 4080 GCAGGGCAGC CAGCAGCGCG CAGCCGACGG CCAGCATGCT TCCTCCTCGG CTACCACTCC 4140 ATGGTCCCGC AGAGGCGAC AGGCGCBCGC CTCTTGCCBC CTCCTGCGCB GGGCBGCGCC 4200 TTGGGGCCBG CGCCGCTCCC GGCGCGGCCB GCBGGGCBGC CBGCBGCGCG CBGCCGBCGG 4260 CCBGCBTGCT TCCTCCTCGG CTBCCBCTCC BTGGTCCCGC BGBGGCGGBC BGGCGCTGCC 4320 CGGCGGGGTG TGCGCTTGGC GCTCCCGTGC TCGGTTCTCT GTCTCCCGGT CCCCCTTGCC 4380 TGGCGTCTCG GGCCTTCGTC CTCTTCCTCT TCTTCCTTCC GCTCCGTGGG GGCTGCTTGG 4440 TGGGGGCCTG TGCCTCGGGG TCCCGGGGCT TCTGGCCCTT GCCGTTCATG GTGGCTAGGT 4500 GGGGCGTTCB TGGTGGCTBG GTGGGGCGGG GTGGGTBGGC CGTGTCTGGG GGTTGGCCBT 4560 GTTGGTTGCC TCTTGGTGGT GCGCCGGGCG CGTCTTGGCT TTCTTCTCCT TCGGGCCCTC 4620 GGGCCGGTGC TTGTGGGCTC CTCCCGGGCG GCCTCCCCGG GCGGGGGCTT CTTGGCGCTG 4680 GCGGGGGGGC CTCCTGCTCT GTGGCTGGGC GTTCCTTGGT GTTCTGGGTG GTGGCGGGCG 4740 TGGTGGCCTC TGTGGGGGCC CGCGGCTGCB GGGGTTGCCT GTCTGCTTCG TCCTTTGCGC 4800 TCCCGGGCCG CCGGGGTGGG TAGGCCGTGT CTGGGGGTTG GCCATGTTGG TTGCCGGGCC 4860 CGCGGCTGCA GGGGACAGGG GCTGTAATCT TCATCTGCAG GTGGCATGCC AGTGAAATTT 4920 AGATCATCAA AATCCCACAT CTGTGGATCT GTAATATTTG ACATGTCCTC TTCAGTTTCA 4980 GCAATGGTTT GATCTAACTG AAGCACCGGC CAGGBCBGGG GCTGTBBTCT TCBTCTGCBG 5040 GTGGCBTGCC BGTGBBBTTT BGBTCBTCBB BBTCCCBCBT CTGTGGBTCT GTBBTBTTTG 5100 BCBTGTCCTC TTCBGTTTCB GCBBTGGTTT GBTCTBBCTG BBGCBCCGGC CBGGTGGCTC 5160 GGTGCTTCTG CCCCTGTTGT TGCGGCGCTC GGTTGGTGTG GCCCCTGTGG TGCTTCGTTT 5220 CCCCCTCTTT CTCTTTGTTC GGGGGTTCTT GTGGCGGGCT GCTTGTCTCG TTCCGCCCTG 5280 TCGGGCGGGA AGCCTCTCTC CTCTCCCCAG ATCCGCGACA GGCCGCAGGC AAGAACCAGC 5340 GCAACCAGGG CGCGTCCGCA CAGACTTGGA GGCGGCTGCA TGCTGCTACC TGCTCCAGAA 5400 GCGTCCGGTG GCCGCCGCGC CCTGTCGGGC GGGBBGCCTC TCTCCTCTCC CCBGBTCCGC 5460 GBCBGGCCGC BGGCBBGBBC CBGCGCBBCC BGGGCGCGTC CGCBCBGBCT TGGBGGCGGC 5520 TGCBTGCTGC TBCCTGCTCG GGCGGGBBGC CTCCGGTGGC CGCCGCGCGT CCGGTGGCCC 5580 CCGCGCCTCT CTCCTCTCCC CGTGGCCCTG TCGGGCGGGT CCTGCCGTCC TGTCTCCTTT 5640 TCTTTTGCTG TCTTGTCTTC CCGTCTCTGC TTTGTCTGTC CTCCCCGTCT CCTCCCACTG 5700 CTTCTCCCGG GGGCTTCCCC GGCTTCGGGT GGCCGGTGTC CCGGGCTCCG GCGCGGCGGC 5760 GGCTTCGGCT GCGGGTGGGT GGCGCGGGCT GCCGGGTCCG CGCGGCGCCT GGGCCCTTGT 5820 GCTGCTTTTT GCTTGTTCCG TTCTGGCTGC TCCGGTCTGT GTTGTGGTTG TTTTGTTTCT 5880 TCTTGGGTGT GGGCCTTGCG GTTTTGGCTG TGGGCCCTTT GGGGCCTTGG CTTCTGGCTC 5940 GTCTGTCCTC CCCGTCTCCT CCCACTGCTT CTCCCGGGC CTTCCCCGGC TTCGGGTGGC 6000 CGGTGTCCCG GGCTCCGGCG CGGCGGCGGC TTCGGCTGCG GGTGGGTGGC GCGCGCTGCC 6060 GGGTCCGCGC GGCGCCTGGG CCCTTGTGCT GCTTTTTGCT TGTTCCGTTC TGGCTGCTCC 6120 GGTCTGTGTT GTGGTTGTTT TGTTTCTTCT TGGGTGTGGG CCTTGCGGTT TTGGCTGTGC 6180 GCCCTTTGGG GCCTTGGCTT CTGGCTCCAT CCACATGATT GCTTAGATTT GTGCTGTATC 6240 TCTCAGGATT ATCACTGATT ACACATCCAA CCAGTGCCAG CCAAAAGGAT GCCCTGAGGC 6300 AAAGGGTTTC CATCTTGAGG CAAATTTGAG GACBTCCBCB TGBTTGCTTB GBTTTGTGCT 6360 GTBTCTCTCB GGBTTBTCBC TGBTTBCBCB TCCBBCCBGT GCCBGCCBD BGGBTGCCCT 6420 GBGGCBBBGG GTTTCCBTCT TGBGGCBBBT TTGBGGBGGG CTBBGBTGBT CCBCBTCBCT 6480 BCCBCGTTGC CCBCCBCBGB GGTCBCCBCB BTGBCCGTGT BGGCBGCTGC CCBBBGGBCB 6540 BTTTGCCBGG CTGGTTGCBC GBBCTGBTTG GGTTCCGBGG TGTTBGTGGB GBTGTTTGGG 6600 GBGBGGTCTG BGTCCBCCGG GBGGBCGTTB TCCBTTTCGB BGCTBGGCGG TBBBGCCCTB 6660 CTBTCTGTBC BCBBCCCCCC TCTGCBGCBG BGTCCTGTCT TCGCGCCTGG GGCTCBGGGT 6720 CCGGCCTAAG ATGATCCACA TCACTACCAC GTTCCCCACC ACAGAGGTCA CCACAATGAC 6780 CGTGTAGGCA GCTCCCAAA GGACAATTTG CCAGGCTGGT TGCACGAACT GATTGGGTTC 6840 CGAGGTGTTA GTGGAGATGT TTGGGGAGAC GTCTGAGTCC ACCGGGAGGA CGTTATCCAT 6900 TTCGAAGCTA GGCGGTAAAG CCCTACTATC TGTACACAAC CCCCCTCTGC AGCAGAGTCC 6960 TGTCGTGGCG CCTGGGGCTC AGGGTCCGTC CTGTCGTGGC GCCTGGGGCT CTTCTTTTGT 7020 GGGCTCTTTG GTGGCTGTGG CTGTGGTCTC TGTGGTTGCT GCCCTGGGTC TGGGGGTGTG 7080 GCCTTGGGGC CCTCCTCTGG CTCCTCCTCG TGGGCCCCCG GTGBCBTTGB GCBTGTCGGC 7140 GCGGTCCCCT TBBGBGTGCG CCCGCCAGCC CAGCCACTCC ACTTGGGGGC GGGTGGCCAG 7200 CACGAACAGC ACCCAGAGGA AGGGGGGCGG CCCAGAAGGG CAGCCCGCAG GCCAGGATCA 7260 GGTCTGCTGC GGCCGGACAT AATGGCATTC ACCACGCGGC GGCCCAGCGC ACGCCGCGCA 7320 TCCGGCCCGG GTTCTGACCT GCAGCCCCCG TCTCCTTGGC ATTCCTGGGC CCCAGTCACT 7380 CCTCTCCCTG CCCCCCTTGC TGGGGCAGGG ACGGGGTGBC BTTGBGCBTG TCGGCGCGGT 7440 CCCGTTBBGB GTGGGCCCGC CAGCCCAGCC ACTCCACTTG GGGGCGGGTG GCCAGCACGA 7500 ACAGCACCCA GAGGAAGGGG GGCGGCCCAG AAGGGCAGCC CGCAGGCCA GATCAGGTCT 7560 GCTGCGGCCG GAGATATGG CATTCACCAC GCGGCGGCCC AGCGCACGCC GCGCATCCGG 7620 CCCGGGTTCT GACCTGCAGC CCCCGTCTCC TTGGCATTCC TGGGCCCCAG TCACTCCTCT 7680 CCCTGCCCCC CTTGCTGGGG CAGGGACGGC CGTGTTTCB GTGGTGCTGC CCGTTTGBGG 7740 TBTGGCGCTC CBCCBBTTCC CTTTTCTCCT TGTTTTCCCT TTCTCTTGCC GTCTGTGGTT 7800 (2) INFORMATION FOR SEQ ID NO:2410: Gi) SEQUENCE CHARACTERISTICS: WO 00/09525 PCT/US99/17712 EPI-109 568 (A) LENGTH: 6225 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2410: CTTGCTCCTG GGGGCCTCCT GGTCCCTCTG GCTGTTCCCG GCCCTGGBCT GGGGCBGGGG 60 CCGCGTBGGC GCGGCTCGCC BGGBCGGGCB GCGCCBGCBG CBGCBGGCTC BGCBTCCTGG 120 CCBCGGBBTT CCGGTGTGCG GGGCCTGGTG CCCCTGGGCC TCGGGTGCTG CCTGTGCGCT 180 GCCTTCTTCT CCTGGGTCCT CGCCGGGGCC CTTGCTGCCC TGGCTGTGCC CTGGGGGTCT 240 GGGTTCGGCT GTCCCCBGCB GGBCCBGTCC CBTCCBCBGC GTGTGBTGBG TBGCCBTTCT 300 CCTGCBGCCG BGGGGCGCGG GCGBGCBTCG CTTTGGGCTT TTCTCCTTTG GTTTGBGCGC 360 CBGGBCCGCG CBCBGCBGCB GGGCGCGGGC GBGCBTCGCB GCGGCGGGCB GGGGGGCTCC 420 CGCCGCGBGB GGTTBTGGGC TCCCBGGBCC BCCCGCBCCG CGCGGBCGTT TBCBTTCGCC 480 BCGCBGTGCG CGGCCGBCBT GBCGBBGTTG GGCGCBBTCB GGGTGGCGCC GCBGBBGTGG 540 CCTCCGCGCB GCTGCBGGGB CBCCBTGBBG GGCCBCGCGT GGGGCCGCGC TCGCCGGCCC 600 CCCBCBBTCT CCGBGGCCBG CGCGGTGCCC CCCBGCBGCB BGGCCGGCBG GBCBCBGGCG 660 BGGBGBCBCG CGBGTCGGCG GCCGBGGGTC BTGGTGGGGC TGGGGCTCCG GGGTCTCTGC 720 CCCTCCGTGC TGGTGGGGCT GGGGCTCCGG GGTCTCTGCC CCTCCGTGCC GCGTGGGGCC 780 GCGCTCGCCG GCCCCCCCCT GCCGGGTGGG CTCCCGCCGC GCGCCGGCCT GCCGGCCCCT 840 CGTGGGTCCT GCTGGCCGGG TCCGGGTCCC GGGGGTGGGG CGCGBGTCGG CGGCCGBGGG 900 TCCCCTCCBC BTCTGCTCTG BCCTGCTGGB CTCTGGBTCT GBBGBTBCGC CBTGTBGGGG 960 CGGGBGTGGG GCCTGCTCTC CCGGCCTCCG BTGBTCTCCC CTGCCTCBGC CCCBGTGGGT 1020 BGGBGBBBGG CCBGCBGBBG CBGGBGTGGC TGCBTCTTTC CTGGTGGGGC CTGCTCTCCC 1080 GGCCTCCGTG TGTTGCTGGG TGTTTTCCCG TCTCTGGTCT GCCTTCGGGG GTCGTCCGGG 1140 GCTGCBGCBB CCTCBTCEGC TCTTGCCTGG BGTGGCTCBG CCTGGGCCTG CBGGGCCBCC 1200 BGGBGBBTGG CBGCBBGGBT GGCGBGGGTC CTCBTGGCTG GGGTCBCBGB TCCTCTBGCT 1260 BGGCBGGGTG BCCBGBGBGG GCGGGTCCTC BTGGCTGGGG GCCTGGGCCT GCBGGGCCGC 1320 TCTTGCCTGG BGTGGCTCGC CCBGBGTCTT CCCTGGTCGC TGCBBTCTGC TCCGGGGCTG 1380 CBGCBBCCTC BTCBGCTCTT GCCTGGBGTG GCTCBGCCTG GGCCTGCBGG GCCBCCBGGB 1440 GBBTGGCBGC BBGGBTGGCG BGGGTCCTCB TGGCTGGGGT CBCCTGGBGG BGGGBGBGCB 1500 GGGGGTCCTC BTGGCTGGGG TCCCTCTCTC CCGTCCTCGG TTTCCTTTGC GGTCTTGGCC 1560 CGGGCTCCGG GTGCCCGCCC GCCCGCCGGC CGCCGCCCCG CCGGGCTGTC CCCGCCCCGC 1620 CCCGGCCCGG GGCGCGGGGG CGGCCCTCCC GCCCCTCTGG GCCGGCGCGG GCGTCGGCCG 1680 CTCGCGCCTG GGGTTCCCTC TCCTCCCCCT GTGCGCCTGC CTCTTGCTCT TCTGCGTCCG 1740 CTGCCTTCTC CCCTCTCCTC GGCCGTTGCC TGTGCTGTCC GTCCTGTCGC CCTTCCGTGG 1800 TGCTGTTGTC TCTTCTGCCC TCGGTGTGCT GGTGCTGGTG GTGGTGCCTC TGCCCGTGCT 1860 CGCCCTGCCT GGGCTGGCCT CTTCGGGTGT GGCTTTGGGG CTCTCTTGGT TGCCCTTTCT 1920 TCTCGTGGTG CCTCTCCTCC CTGGCTTGGT CGTTGTCTGG GGTGGTGCTC CTCTCCCTTT 1980 CCCTGCTGGC CGTTTGTCCT GTTTTCTGTC TTCCTCTTTC CTCCTGTTTC TCCGTTTGGC 2040 TTGCTGCTTG CGGGGCTGTC TCCCTTGCCC CTGTGGGCTT TCCCTGGTCC GGTCTTCTCC 2100 TTGGGGGTCG CCCTTCTTGG TGGGCTGGCT CGTCTGTCTT TTTCCTTCCT GGGGGTGGCC 2160 GTTGTGGGCG GTGTGGTCCG CCTTGCCTCT GCTGGTCTTT CCTCGGTBGB CGCGCTCGBB 2220 CTCGGGTGGG CCGGTGGTGB GCGGCGGCGB CBCGCGGBBG GCCCTGCGCG CCGBGBTCBC 2280 CTGCBGGGBG BBGTBGGCTT GCBGCBGGBC TCCCBGGBGG GTGBCBGCBG CCBGTBGBGC 2340 TBCCTCGTCC TTCBTGGTBC CGTCGGTGTG GTGGCBCGGG CTGTGTGTGB BGGCGBGCTG 2400 GGCCCCGTCT GCTGCTCCTC GTGCCGCCTC GTCCTTCATG GTACCGTCGG TGTGGTGGCC 2460 TCGGGTGGGC CGGTGGTGGG GCGCGCGCGC TCGCGTGGCT CCGGCTCTTC TTTCCCGGCT 2520 CCGTCGGCCC GGGGGCCTTG GTCTCCCTCG TCCTTCBTGG TBCCGBCCGG CGGBGCCGCC 2580 BGGGTGGBCT GGGBGTGGGT TTCTCCCCGC CGTTCTCBCC CBCCGCGCTG BGCTCBGCGC 2640 CTBBGBCTGC TGTTTCTGGB GCTCCTTGGC BBGCCBCBBB CBGCBGBGBG BBBBTCBTGB 2700 GCBBBTBBTC CBTTCTGBBB BBBBGGGBTC BBBBBCCTCC CGTTCCCCGT TCGCCTGGCG 2760 CGCGCTGCGG GTTCCTCGTG GGTTTCTCCC CGCCGTTCTC CGGTCTGTTG CCTTTGTGGG 2820 CTTCTTGTCT TTTTGGCTGT TCTTTTCCTG CTTGGCGTCT TTTCCTTTCT TTGTGCTCGG 2880 TTGTGGGTCC GCTGGTCCTT TGCCCTGTGT GTTTCTGCTG CCCGTTCGCC TGGCGCGCGC 2940 TGCGGGTTCC TCGTGGGTTT CTCCCCGCCG TTCTCCGGTC TGTTGCCTTT GTGGGCTTCT 3000 TGTCTTTTTG GCTGTTCTTT TCCTGCTTGG CGTCTTTTCC TTTCTTTGTG CTCGGTTGTG 3060 GGTCCGCTGG TCCTTTGCCC TGTGTGTTTC TGCTGGGBGC TGBTBCTGCB GATTTCBGBG 3120 GGBBGBBCCC TGBTBCTCBC CBGCTTCBGC TCTGGBGCBC BBGBGBBBGB GCBGCBGGGG 3180 GBGBGGBBGB BGCBGCBTCT TCCCBGBGBG GCTGCCTGBG CBBBTGCTGG TTTTCCTTTC 3240 CBGTCTTGGG TTTTBTBBCT CCCBGBBGGC BBGBGBGGGG CBBGGCGTTT TCTTCTCTCG 3300 CTGGTTTTCC TTTCCTGGCA GTGGGTGGGG GTGGGGGTGG GGTGGCTTCC TTGTTCCTGG 3360 GGGTGTCCTC TTGCTCTGGG CTTTTCTCCC CTTTTCCTTC CTGTCTGTTT TCCTGGGGCT 3420 CTCCTCTGTC TCTGTGTCCT TGCCCTGGCC CTCTTCCCTC TCCTGTCTCC TGTCCCTGTG 3480 TTCCGCCCGT CTTCCCTCTC CTGACCTCCT TTTCCTCCGC TGGGTGGGGC CCTGCCTGTT 3540 CTCTGCTCCC TGGCTTGGGG TTTCTTCTGT GTGTCTTCTT CCTCTGTTGG CTGGCTTTCT 3600 CCTTCTTTTG TCTTCCTGGG TGCCCCTTCT TCCTTTCTTG GGTCCTTGGT GCTTGGGCTG 3660 GGGCGTCTTG GGGTGCBGGG CCCBTCCTGC TGCGCCTGGG CGCTGCTGTG CGTCCGTCTG 3720 CTGGGGGGCC GGGGTGGCTG GGCCCTGCTT GCCGCACGAC CCCGGGCCGA CCCGAGGCTC 3780 GGGGGGCTGT GTTCTGGCGC TGGTGGGCTT GGGCCCCTCT GGGGGCTGGG TTTCCTGCTG 3840 CGCCTGGGCG CTGGCGTCTT GGGGTGCGGG GCCGGGGGGC CGGGGGGCCG CTGTTCGTGG 3900 GCCTGGGGGT GCCTGTGGCT GCCGGTTGCC CCGGTTGGTG GCGCCGTCCT GCTGCCGGTC 3960 GTTGGCTGGG TCCCCCCGCC CGTTTCCTGG GGTCCGCGTG GGGTGCTCCG GTTCCTCGTG 4020 CCGCTGCTGC CTTGTCTTTC CGGCCGTGGC GGCGTGGTGG TCCGCCCCCC CTGGCCTTCT 4080 GCTCGGGGTC TGGCTGGTTG CCGGTGCCCT TGGCGGCGGT CTTCTTCCTG GTGGCTCTGG 4140 GCCCGGCCGG TCTCGGGCGT CTCGTGTTCG CTCTTGTGCT GTTCCGGCCG CTCCTTCCTC 4200 WO 00/09525 PCT/US99/17712 EPI-109 569 TTCCGCCGCC GCCGCTCCCC GCCCGCTCGT CGCCCTGGCC CGGCCTCCTC CTGGCCGCTG 4260 TCTCGGGCGG CGGCCTTGGC GCTCCGTTTG GGGCTGCCTC TGGCGCTTCC GGCCCTCGGC 4320 CTGGGCGCTC TCTTCCGCCT GTGCTGGTGG CCCTCGTGGG CCCCTCCTGG CCTCCGGTGT 4380 CCTGTGGTCC CCCGGCTGGT GGCCGGGCCG GTTGGGCGGG CGTGGGCGCC GGCGGGTCCT 4440 CCGGGCTGCC CTTCTCCGCC GGGGGTCCCG CGCTCCTGCT GTTCCCTGGG CTCTTCTGCC 4500 TCTCTCCTGG GTGGGTGCTG GGTGCCGGGG TCTCCGGGCT TGCCCCGCGC TGCTGGGCGT 4560 TCTGCGGTCT TGGGGTTGTC TGTGGCCCCG CTCGTGTCGC CCTCCGTCGC CCGTCGCCGG 4620 CCTCGTCCCC TCCTGGGTGC GCGGCGGGCT GGTCCTGGCG TTTTGCTCCT TCCTGGGCGT 4680 CTTGGGGTGC BGGGCCCBTC CTGCTGCGCC TGGGCGCTGC TGTGCGTCCG TCTGCTGGGG 4740 GGCCGGGGTG GCTGGGCCCT GCTTGCCGCA CGACCCCGGG CCGACCCGAG GCTCGGGGGG 4800 CTGTGTTCTG GCGCTGGTGG GCTTGGGCCC CTCTGGGGGC TGGGTTTCCT GCTGCGCCTG 4860 GGCGCTGGCG TCTTGGGGTG CGGGGCCGGG GGGCCGGGGG GCCGCTGTTC GTGGGCCTGG 4920 GGGTGCCTGT GGCTGCCGGT TGCCCCGGTT GGTGGCGCCG TCCTGCTGCC GGTCGTTGGC 4980 TGGGTCCCCC CGCCCGTTTC CTGGGGTCCG CGTGGGGTGC TCCGGTTCCT CGTGCCGCTG 5040 CTGCCTTGTC TTTCCGGCCG TGGCGGCGTG GTGGTCCGCC CCCCCTGGCC TTCTGCTCGG 5100 GGTCTGGCTG GTTGCCGGTG CCCTTGGCGG CGGTCTTCTT CCTGGTGGCT CTGGGCCCGG 5160 CCGGTCTCGG GCGTCTCGTG TTCGCTCTTG TGCTGTTCCG GCCGCTCCTT CCTCTTCCGC 5220 CGCCGCCGCT CCCCGCCCGC TCGTCGCCCT GGCCCGGCCT CCTCCTGGCC GCTGTCTCGG 5280 GCGGCGGCCT TGGCGCTCCG TTTGGGGCTG CCTCTGGCGC TTCCGGCCCT CGGCCTGGGC 5340 GCTCTCTTCC GCCTGTGCTG GTGGCCCTCG TGGGCCCCTC CTGGCCTCCG GTGTCCTGTG 5400 GTCCCCCGGC TGGTGGCCGG GCCGGTTGGG CGGGCGTGGG CGCCGGCGGG TCCTCCGGGC 5460 TGCCCTTCTC CGCCGGGGGT CCCGCGCTCC TGCTGTTCCC TGGGCTCTTC TGCCTCTCTC 5520 CTGGGTGGGT GCTGGGTGCC GGGGTCTCCG GGCTTGCCCC GCGCTGCTGG GCGTTCTGCG 5580 GTCTTGGGGT TGTCTGTGGC CCCGCTCGTG TCGCCCTCCG TCGCCCGTCG CCGGCCTCGT 5640 CCCCTCCTGG GTGCGCGGCG GGCTGGTCCT GGCGTTTTGC TCCTTCCTGG CTGCCCCBGT 5700 TTTTGBTCCT CBCBTGCCGT GGGGBGGBCB BTGGCTGCCT CCCCGGGGTT TCTGCTGCTT 5760 GCTGCTTCTT TCCCGTCTCC CTTCTTTCCC GTCTCCTTTT TGCCTCTTTG GGTTCCTGTT 5820 GTTTCTGGCC TGCTTGGTGG CGGCTTGTGC GTTTCCTCTC TCTTCTCTTG GGTCTCCGCT 5880 TCTCGTCCTG CCTTTTCCTG TCTCTGTCGC GCCGTTCCTC CTCCGGCGTC CTCCTGCCCT 5940 GTGCTGTTTG CCTCGGGTGG TGCGGGTCCC GGTGCTCCCC CGGCGGGCCG GCTGGTTGCC 6000 TGGGCCTGTC TGGTGGGGTG TGGGGCCGCT GGGTTGGGGG TGTGGTGGGC TCTTCTGTGG 6060 CCTGTGGGGC TGTTGGTGTC TCTGTGGGCG TGTGCTGGGT CTTGGGGCTT CCTCCCTTGT 6120 GCTGGGTGCG GCCTCCCCGC CCCCCTTCTG GGCCGGTGGC CTGGCTCCTT GTGGGCGCTT 6180 CTGGCTCTTG CCCTGTCCTT CTTCGCCTCG TGGCTGCTGG GCTGC 6225 (2) INFORMATION FOR SEQ ID NO:2411: Ci) SEQUENCE CHARACTERISTICS: (A) LENGTH: 7033 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (DT TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2411: CCTCCTTCCT GGTCTGTCTG CCBGBCBBBT TTGGGBBGTG BBCBGTTTTG GBBCCBTGTT 60 TCCCBGTCTC TGBGCTGTGG CGCCCTGCTG CTCTTTCTGC TTCCCTTGGT GGGTTGGGCC 120 GCTGGTTGTT CTGGGGTTCT TGCTGCCCCT TCTGTCCCTG TTTGCTGGTG TCTGCGCCCC 180 CBBCBGBBGB BGCBGBCBBB TTTGGGBBGT GBBCBGTTTT GGBBCCBTGT TTCCTGTGC 240 CTCGGCCTGG TCCCGGGGGT CTCCTCTTGT TGTTGCTTGC GCCTCCTGCT GGGGGTCCCT 300 CTGTTCTTGT TTTGGGGGCG GGCCCGGCCG TTGTCTTGGT TTGGGGGTTT CCGTTGGGGT 360 TCTCCTGGCC CGGGCCTTGC CCGGCCGTGG TCCCGGCTTC GTTCCTGTCT CCGTCTCGGC 420 TCTTCTGGGG CCTTGCGCTG TCTTTGGTGG CBCCGTCCBG TGBTGGTGCG GTBCTTGTCG 480 CTGCBGCGCT CGGCCTGGTC CCGGBGBGCG CGCGGGCCGG GGGCTGCTGG GGGTTGGCCC 540 GGGGTGCCCC GCCGCTGGGT GCCCTCGTCC TCTGCGGTCG TGTCTCCTGG CTCTGGTTCC 600 CCGCTGCGCC CGTTGTCCTC TGGGGTGGCC TTCGCTCCCG GGTCTGGTTC TTGTGTTGGG 660 GGTCCCTTTT TGGGCCTGTT GTGGCGTGGC TTGTGTGTTC GGTTTCTGCC CTGTCCTCCG 720 GCGTCCCCGG BGCCTCCCCG GGGCBGGBTG BCTTTTGBGG GGGBCBCBGB TGTCTGGGCB 780 TTGCCBGGTC CTGGGBBCBG BGCCCCGBGC BGGBCCBGGB GTGCGGGCBG CGCGGGCCGG 840 GGGCTGCTGG GBGCCBTBGC GBGGCTdBGC CTCTTTTCTG TTTTTCCCCT CTGCCTTTGT 900 TTGGGTTCGC TTCCTTTCTG CTTCTTCCCT GTGTCTCCTG TCTCCGCTTT TTTCTTCGTC 960 TTTGTTGTTT TCTCTTCCTT GCTGBGCBBG BTBTCTBGBT TCTGGGGTGG TCTCGBTTTT 1020 BBBBGCTTGB GBBGCTGCBB BCBTTBTCCB BBGTBTBTTT GBGGCTCCBB GGBTCBCGBC 1080 CBTCTTCCCB GGCBTTTTBB GTTGCTGTCG TBBGTGBGBG CTGBGBGBBB CTGTGBBGCB 1140 BTCBTGBCTT CBBGBGTTCT TTTCBCCCGT TCTTGGCTTC TTCTGTCCGT TGGCTTCTCG 1200 TTGTCCCTGT GGGCTTCTCG TTGTCCCCCC TTCGGGGGCT GGTGGGGCCG TCCTTGCCTG 1260 CTGGGTTCTT GGCTTCTTCT GTCCGTTGGC TTCTCGTTGT CCCTGTGGGC TTCTCGTTGT 1320 CCCCCCTTCG GGGGCTGGTG GGGCCGTCCT TGCCTGCTGG TTTTCTCTTT CGCTTTCTTT 1380 TCGTCTCCTG TTCCTCCTTT TTTGCTGTTT TTTCTCCTTC TTCTCTCCTT TCTTTTCTTT 1440 TCTCTTTCGC TTTCTTTTCG TCTCCTGTTC CTCCTTTTTT GCTGTTTTTT CTCCTTCTTC 1500 TCTCCTTTCT TTTCCTCTGT CTTGTTCTGG TCCTTCGTGG GGCTCTGTGT CGCGTGGGTG 1560 CGGCCGTGGC CGGCGGBCCB GGBGTTGGBG CBGGBGCBGG BCGGGCBGGC GGCTCBTGTT 1620 TGGBTCGGCB GGBGGCBCTC CTCTGGTTGG CTTCCTTCGC CGGCBCBTGC TBGCBGGBBG 1680 BBCBGBGGGG GBBGCBGTTG GGBGGTGBGB CCCBTTBBTB GGTGTCGBTC CCTGTTTCCC 1740 CCCTTTCGTT CTGCGTTTGC CTTTGGCGTT TTTTGTTTGT TTTCTCTCTC CGTCTTTCTT 1800 CTCCCCTGTG GGBBTTTCTG TGGGGBTGGC BTBCBCGTBG GCBGCTCCBB GBGCTBGCBB 1860 BCTCBBBTGC BGBBGCBTCC TCBTGGCTCT GBBBCGGTGG GAATTTCTGT GGGGBTGGCA 1920 TACACGTAGG CAGCTCCAAG AGCTAGCAAA CTCAAATGCA GAAGCATCCT CATGGCTCTG 1980 WO 00/09525 PCTIUS99/17712 EPI-109 570 AAACGGGGGG TGGCTTCCTG CCGCGTCTCT GGGCCGTCCC GTCCCTCGGC CCCGCGCCGC 2040 GCTCGGCTCC TCTCCCTCTG GCCCGGCTCG GGGCGGGGCG GGGCGGTGGG CGGGCGGCGC 2100 TGCCCTGCGC GCGGCGCTGG CCCCTGCTGG CCGTCGGCTG CGCGCTGCTG GCTGCCCTGC 2160 TGGCCGCGCC GGGGCCTGTC CGCCTCTGCG GGCGCTGTCT CCTGGCTTGT CTTCCGGCTC 2220 TTCTGCTGGG GTGGGGCTGG GCGGCCGGCC CGGTGCTGGG GCTCCTCGGG GGGGGGGGCT 2280 CTTCCGGGCT GTCTCCCTCC GGGGCGGGGG TTTCTGGCCG TGGGGGTCTT GCCTGGCCTC 2340 CGGGCTCCTG CTTGTCTTGC CTTCCTTCTC TGGTCGGTTG TGGCTCGGGG CTCCGTGGGT 2400 CCCTGGCGCC CGTTTGTGTT TTGTCTTTTC CCCTGGCGTC CCTGTGCCCC TCTCCTCTCC 2460 TTCCTCTGCT TCTCGCTCTC CTTTGTGGGG CCCTCCCTGC TGCTCTTGGT TTTGGGCTTT 2520 TTTTCTCTTC CTCCTTTTTC GTGCGTGGGC CTCCGCACGC CTCTTGCCAC CTCCTGCGCA 2580 GGGCAGCGCC TTGGGGCCAG CGCCGCTCCC GGCGCGGCCA GCAGGGCAGC CAGCAGCGCG 2640 CAGCCGACGG CCAGCATGCT TCCTCCTCGG CTACCACTCC ATGGTCCCGC AGAGGCGGAC 2700 AGGCGCBCGC CTCTTGCCBC CTCCTGCGCB GGGCBGCGCC TTGGGGCCBG CGCCGCTCCC 2760 GGCGCGGCCB GCBGGGCBGC CBGCBGCGCG CBGCCGBCGG CCBGCBTGCT TCCTCCTCGG 2820 CTBCCBCTCC BTGGTCCCGC BGBGGCGGBC BGGCGGGGTG GBBBGGTTTG GBGTBTGTCT 2880 TTBTGCBCTG BCBTCTBBGT TCTTTBGCBC TCCTTGGCBB BBCTGCBCCT TCBCBCBGBG 2940 CTGCBGBBBT CBGGBBGGCT GCCBBGBGBG CCBCGGCCBG CTTGGBBGTC BTGTTTBCBC 3000 BCBGTGBGBT GGTTCCTTCC GGGCTTGTGT GCTCTGCTGT CTCTTGGTTC CTTCCGGTGG 3060 TTTCTTCCTG GCTCTTGTCC TTTCTCTTGG CCCTTGGCCG GGBGTGGGGG TCCTGGBCGG 3120 CBCTGBBGGC BTCCBGGGCT CCCTTCCBGT CCTTCTTGTC CGCTGCCBGC BCCCCTTCBT 3180 TCCBGBGGCT GBTGGCCTCC BCCBGGGBCB TGBTTBGGTB GBBBCTBGGB GGCCGGCCTC 3240 CBCCBGGGBC BTGGTCCTTC TTGTCCGCTG CCTCTCTGGG GTTTTCGGTC TGGGTGGGCT 3300 TTCCTCCTGG GGCTGCTGCT GGGCTCTTCT TTTTGTTTCT GGCCTGGTGC TCTCTCGTGC 3360 CCTTTCCCTT GGGTGTCTTG TTTTTGTGGC CTCCBCCBGG GBCBTGGTCT TTGTTTCTGG 3420 GCTCGTGCCC CBTCCCGGCT TCTCTCTGGT TCCGTCCTCT GTGGTGTTTG GCCCTGCTTC 3480 CTTTTGCCTG TTGAGGGGGC AGCAGTTGGG CCCCAAAGGC CCTCTCGTTC ACCTTCTGGC 3540 ACGGAGTTGC ATCCCCATAG TCAAACTCTG TGGTCGTGTC ATAGTCCTCT GTGGTGTTTG 3600 GAGTTTCCAT CCCGGCTTCT CTCTGGTTCC AAGGGAGBGG GGGCBGCBGT TGGGCCCCBB 3660 BGGCCCTCTC GTTCBCCTTC TGGCBCGGBG TTGCBTCCCC BTBGTCBBBC TCTGTGGTCG 3720 TGTCBTBGTC CTCTGTGGTG TTTGGBGTTT CCBTCCCGGC TTCTCTCTGG TTCCBBGGGD 3780 GGGCBCGGGG CBGTGGGCGG GCBBTGTBGG CBBBGCBGCB GGGTGTGGTG TCCGBGGBBT 3840 BTGGGGBGGC BGBTGCBGGB GCGCBGBGGG CBGTBGCBBT GBGGBTGBCB GCGBGGCGTG 3900 CCGCGGBGBC CTTCBTGGTB CCTGTGGBGB GGCTGTCGGB GGGGGTGTGG TGTCCGCTTG 3960 GCGGTTCTTT CGGGTGTTTC TTCTCTGGGT TGGCCTGCTG CTCGTCGTGG TCGCTCCGCT 4020 CCCGGGTTCG TCTCGCTCTG TCGCCCCTTC CTTCCTTGTC CTGTTCCTCC CTTCCTTGCC 4080 TCTGBTGTTT GTTBCCBBBG CBTCBBGBBT BGCTTTGCTB TCTBBGGBTC BCBTTTBGBC 4140 BTBGGBBBBC GCTGTBGGTC EGBBBGBTGT GCTTBCCTTC BCBCBGBGCT GCBGBBBTCB 4200 GGBBGGCTGC CBBGBGBGCC BCGGCCBGCT TGGBGTCBTG TTTBCBCBCB GTGBGGTGCT 4260 CCGGTGGCTT TTTGCTTGTG TGCTCTGCTG TCTCTGTTCC TTCCGGTGGT TTCTTCCTGG 4320 CTCTTGTCCT TTCTCTTGGC CCTTGGCCCC TTGBGCBGGB BGCTCTGGGG CBGGGBGCTG 4380 GCBGGGCCCB GGGGGGTGGC TTCCTGCBCT GTCCBGBGTG CBCTGTGCCB CBGCBGCBGC 4440 TGCBGGGCCB TCBGCTTCBT GGGGCTCTGG GTGGCBGGTC CBCCBTGGC TCTGGTGGG 4500 GCTGGGCTGC BGGCTCCGGG CGGTCCBGCC BTGGTCTGG GGGCTGGGCT GCBGGCTCCG 4560 GGCGGGCGGG TGCGGGCTGC GTGCTGGGGG CTGCCCCGCA GGCCCTGCGG TCCBGCCBTG 4620 GGTCTGGGGG CTGGGCTGCB GGCTCCGGGC GGGCGGGTGC GGGCTGCGTG CTGGGGGCTG 4680 CCCCGCAGGC CCTGCGCBCC GCCTGGBGCC CTGGGGCCCC CCTGTCTTCT TGGGGBGCGC 4740 CTCCTCGGCC BGCTCCBCGT CCCGGBTCBT GCTTTCBGTG CTCBTGGTGT CCTTTCCBGG 4800 GGBGBGBGGG GCTGGTCCTC TGCTGTCCTT GCTGGTGCTC BTGGTGTCCT TTCCGCCCTG 4860 GGGCCCCCCT GTCTTCTTGG GGCCTCTTCC CTCTGGGGGC CGTCTCTCTC CCTCTCTTGC 4920 GTCTCTCTCT TTCTCTCTCT CTCTTCCCCT TTCCCGCTCT TTCTGTCTCG GTGTCTGGTT 4980 TTCTCTCTCC GCTGGCTGCC TGTCTGGCCT GCGCTCTTGG CCTGTGCTGT TCCTCCTCCG 5040 GTTCCTGTCC TCTCTGTCTG TCGCCCCCTC TGGGGTCTCC CTCTGGGTGG TGGTCTTGTT 5100 GCTTGGGCTG GGCTCCGTGT CTCCBGTGCT CBTGGTGTCC GCTGBGGGBG CGTCTGCTGG 5160 CGCTGGTCCT CTGCTGTCCT TGCTGGTGCT CBTGGTGTCC TTTCCGCCCT GGGGCCCCCC 5220 TGTCTTCTTG GGGCCTCTTC CCTCTGGGGG CCGTCTCTCT CCCTCTCTTG CGTCTCTCTC 5280 TTTCTCTCTC TCTCTTCCCC TTTCCCGCTC TTTCTGTCTC GGTGTCTGGT TTTCTCTCTC 5340 CGCTGGCTGC CTGTCTGGCC TGCGCTCTTG GCCTGTGCTG TTCCTCCTCC GGTTCCTGTC 5400 CTCTCTGTCT GTCGCCCCCT CTGGGGTCTC CCTCTGGCGT GGTGGTCTTG TTGCTTGGGC 5460 TGGGCTCCGT GTCTCCBGTG CTCBTGGTGT CCGCTGBGGG BGCGTCTGCT GGCCTGCTGB 5520 GGCTTGGGTC TCCGGGCGBT TCTCTGCBGB BGBTGCTCBB BGGGCTCCGG CBGTTCCTCC 5580 TTGBTCTGGT CGCTGTCGTB CCBGTCGGBC CBGTBBTTCB GBTCBTCBTT GGCTCCTBTT 5640 TCTTCTGCBB BCBGCTGBGT GGBGBCBBGB BBBBBGBCTG CCBBGGCCBC GBGGBTTTTC 5700 BTGTTGGBTT TTGCGBCGGB CBGTCCCGCG GGGTGCTGAG TTTCTCTGGT TCCTCCGBGC 5760 GCBCGTGGTC GCTCCGCGTT TCTCTGGTTC CTCCGGTCCC GCGGGGTGCT GTCTGGTCGC 5820 TGTCGTGGCT TGGGTCTCCG GGCGGTTTCC TTCCTTTTCC CCCGCCCTT CTCACTGGAG 5880 GCACCGGGCA GTCCTCCATG GGAGGGTTGG GCTTGGCCGG GGCTGCCCGG TGCCTCCTCT 5940 TGGCTGGTCC CTCGTTGTCC TTGGGCCCCG CTCCCGCTGC TCGGCCTCCG TGTTCTTTGG 6000 CCTCTTGCTC CGCCTGCTGT CTTGTCCCGT CCCCTCCTCG CTTGCGTTTC CCTCTTCCTT 6060 GTCTTCCAGG CCTTCCTCCG CTTCCGCTGC TGGGCCCGC GCCGGGGGGG CGCTCGGCTC 6120 CGCGGCTTCC TCCCCGGCTG GGGGGTCCTG GTCTCCGGGG CCTGCGGCTC GCGGGCTCGG 6180 GGCTGCGTGC GCCGCGCGCG CTCCGCGG TGGGTGGCGC TGTCCCGCCG TGGTGTGTCT 6240 CCGTTCTCGT CCTGCGCCGT CCTGGTCTGC CCGTGGGGTC CTGGGCGTGG TGGGGGGCGT 6300 CTGGTGCCTC GTCTGCCCCG TGGGGCTTCG GGCTCGGGGC TGTTCGTCCC CCCTCCCT 6360 CTGTGGCCTC CGGGGCTCCT CGTTTTCGCT GCTTCGGGTG TCCTTCTCGG CGTGTGGCCC 6420 CGGGTCCCGG CCCTGCTGGG CTGGGCGGGG TCGCTGCCCT GGGCTTCTGG CCCGTCTGGT 6480 WO 00/09525 PCTIUS99/17712 EPI-109 571 TGTCTGTCGG TGCTTGTCTC GGGTTTCTGG CCTCTGTGCT GGGCGCTTCT CTGCCTCCTG 6540 CTCCGCCCTC CTGGTGGCTC GGCTGGGGGT GCCCGTGCGG GGGTGGGTGT GGGGTGTTTT 6600 CGGGGTCCTC CCCTTCCCGT TTCATCTTGG CTTTATCCTC TCCCCTTGTT CCTCCCCTCT 6660 CCTGCTCTGG RGTCTCCTCT TCCCTCCCTC CCCTGCCGTG TTGTCTGTGG GTGTCGTTTC 6720 GCTCTTGTTG CCCTGGGCCC TTCCCTGCTG GGGGGGAGTT TCATCTTGGG TTTCBTCTTG 6780 GCTTTBTCCT CTCCCCTTGT TCCTCCCCTC TCCTGCTCTG GRGTCTCCTC TTCCCTCCCT 6840 CCCCTGCCGT GTTGTCTGTG GGTGTCGTTT CGCTCTTGTT GCCCTGGGCC CTTCCCTGCT 6900 GGGGGGGBGT TTCBTCTTGG GGGGGBGTTT CBTCTTGGCT TTCCGTGTTG TCBGTGGTGC 6960 TGCCCGTTTG BGGTBTGGCG CTCCBCCBBT TCCCTTTTCT CCTTGTTTTC CGTTTCTCTT 7020 GCCGTCTGTG GTT 7033 (2) INFORMATION FOR SEQ ID NO:2412: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 21 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2412: GATGGAGGGC GGCATGGCGG G 21 (2) INFORMATION FOR SEQ ID NO:2413: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 12 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2413: GCGGGTCGCC GG 12 (2) INFORMATION FOR SEQ ID NO:2414: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 13 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2414: GGCGGGCBCB GGC 13 (2) INFORMATION FOR SEQ ID NO:2415: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 9 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2415: GGCGGGCBC 9 (2) INFORMATION FOR SEQ ID NO:2416: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 9 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2416: GCGGCCTGG 9 (2) INFORMATION FOR SEQ ID NO:2417: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 10 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2417: GGBGGGCGGC 10 (2) INFORMATION FOR SEQ ID NO:2418: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 9 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2418: GBTGGBGGG 9 (2) INFORMATION FOR SEQ ID NO:2419: WO 00/09525 PCT/US99/17712 EPI-109 572 (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 8 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2419: GGCTGGGC 8 (2) INFORMATION FOR SEQ ID NO:2420: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 961 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2420: 1 ATGCCGCCCT CCATCTCAGC TTTCCAGGCC GCCTACATCG GCATCGAGGT GCTCATCGCC 61 CTGGTCTCTG TGCCCGGGAA CGTGCTGGTG ATCTGGGCGG TGAAGGTGAA CCAGGCGCTG 121 CGGGATGCCA CCTTCTGCTT CATCGTCTCG CTGGCGGTGG CTGATGTGGC CGTGGGTGCC 181 CTGGTCATCC CCCTCGCCAT CCTCATCAAC ATTGGGCCAC AGACCTACTT CCACACCTGC 241 CTCATGGTTG CCTGTCCGGT CCTCATCCTC ACCCAGAGCT CCATCCTGGC CCTGCTGGCA 301 ATTGCTGTGG ACCGCTACCT CCGGGTCAAG ATCCCTCTCC GGTACAAGAT GGTGGTGACC 361 CCCCGGAGGG CGGCGGTGGC CATAGCCGGC TGCTGGATCC TCTCCTTCGT GGTGGGACTG 421 ACCCCTATGT TTGGCTGGAA CAATCTGAGT GCGGTGGAGC GGGCCTGGGC AGCCAACGGC 481 AGCATGGGGG AGCCCGTGAT CAAGTGCGAG TTCGAGAAGG TCATCAGCAT GGAGTACATG 541 GTCTACTTCA ACTTCTTTGT GTGGGTGCTG CCCCCGCTTC TCCTCATGGT CCTCATCTAC 601 CTGGAGGTCT TCTACCTAAT CCGCAAGCAG CTCAACAAGA AGGTGTCGGC CTCCTCCGGC 661 GACCCGCAGA AGTACTATGG GAAGGAGCTG AAGATCGCCA AGTCGCTGGC CCTCATCCTC 721 TTCCTCTTTG CCCTCAGCTG GCTGCCTTTG CACATCCTCA ACTGCATCAC CCTCTTCTGC 781 CCGTCCTGCC ACAAGCCCAG CATCCTTACC TACATTGCCA TCTTCCTCAC GCACGGCAAC 841 TCGGCCATGA ACCCCATTGT CTATGCCTTC CGCATCCAGA AGTTCCGCGT CACCTTCCTT 901 AAGATTTGGA ATGACCATTT CCGCTGCCAG CCTGCACCTC CCATTGACGA GGATCTCCCA 961 GAAGAGAGGC CTGATGACTA G (2) INFORMATION FOR SEQ ID NO:2421: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 2881 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2421: 1 ATGAGTGTCA GAAGTGTGAA GGGTGCCTGT TCTGAATCCC AGAGCCTCCT CTCCCTCTGT 61 GAGGCTGGCA GGTGAGGAAG GGTTTAACCT CACTGGAAGG AATCCCTGGA GCTAGCGGCT 121 GCTGAAGGCG TCGAGGTGTG GGGGCACTTG GACAGAACAG TCAGGCAGCC GGGAGCTCTG 181 CCAGCTTTGG TGACCTTGGG CCGGGCTGGG AGCGCTGCGG CGGGAGCCGG AGGACTATGA 241 GCTGCCGCGC GTTGTCCAGA GCCCAGCCCA GCCCTACGCG CGCGGCCCGG AGCTCTGTTC 301 CCTGGAACTT TGGGCACTGC CTCTGGGACC CCTGCCGGCC AGCAGGCAGG ATGGTGCTTG 361 CCTCGTGCCC CTTGGTGCCC GTCTGCTGAT GTGCCCAGCC TGTGCCCGCC ATGCCGCCCT 421 CCATCTCAGC TTTCCAGGCC GCCTACATCG GCATCGAGGT GCTCATCGCC CTGGTCTCTG 481 TGCCCGGGAA CGTGCTGGTG ATCTGGGCGG TGAAGGTGAA CCAGGCGCTG CGGGATGCCA 541 CCTTCTGCTT CATCGTGTCG CTGGCGGTGG CTGATGTGGC CGTGGGTGCC CTGGTCATCC 601 CCCTCGCCAT CCTCATCAAC ATTGGGCCAC AGACCTACTT CCACACCTGC CTCATGGTTG 661 CCTGTCCGGT CCTCATCCTC ACCCAGAGCT CCATCCTGGC CCTGCTGGCA ATTGCTGTGG 721 ACCGCTACCT CCGGGTCAAG ATCCCTCTCC GGTACAAGAT GGTGGTGACC CCCCGGAGGG 781 CGGCGGTGGC CATAGCCGGC TGCTGGATCC TCTCCTTCGT GGTGGGACTG ACCCCTATGT 841 TTGGCTGGAA CAATCTGAGT GCGGTGGAGC GGGCCTGGGC AGCCAACGGC AGCATGGGGG 901 AGCCCGTGAT CAAGTGCGAG TTCGAGAAGG TCATCAGCAT GGAGTACATG GTCTACTTCA 961 ACTTCTTTGT GTGGGTGCTG CCCCCGCTTC TCCTCATGGT CCTCATCTAC CTGGAGGTCT 1021 TCTACCTAAT CCGCAAGCAG CTCAACAAGA AGGTGTCGGC CTCCTCCGGC GACCCGCAGA 1081 AGTACTATGG GAAGGAGCTG AAGATCGCCA AGTCGCTGGC CCTCATCCTC TTCCTCTTTG 1141 CCCTCAGCTG GCTGCCTTTG CACATCCTCA ACTGCATCAC CCTCTTCTGC CCGTCCTGCC 1201 ACAAGCCCAG CATCCTTACC TACATTGCCA TCTTCCTCAC GCACGGCAAC TCGGCCATGA 1261 ACCCCATTGT CTATGCCTTC CGCATCCAGA AGTTCCGCGT CACCTTCCTT AAGATTTGGA 1321 ATGACCATTT CCGCTGCCAG CCTGCACCTC CCATTGACGA GGATCTCCCA GAAGAGAGGC 1381 CTGATGACTA GACCCCGCCT TCCGCTCCCA CCAGCCCACA TCCAGTGGGG TCTCAGTCCA 1441 GTCCTCACAT GCCCGCTGTC CCAGGGGTCT CCCTGAGCCT GCCCCAGCTG GGCTGTTGGC 1501 TGGGGGCATG GGGGAGGCTC TGAAGAGATA CCCACAGAGT GTGGTCCCTC CACTAGGAGT 1561 TAACTACCCT ACACCTCTGG GCCCTGCAGG AGGCCTGGGA GGGCAAGGGT CCTACGGAGG 1621 GACCAGGTGT CTAGAGGCAA CAGTGTTCTG AGCCCCCACC TGCCTGACCA TCCCATGAGC 1681 AGTCCAGCGC TTCAGGGCTG GGCAGGTCCT GGGGAGGCTG AGACTGCAGA GGAGCCACCT 1741 GGGCTGGGAG AAGGTGCTTG GGCTTCTGCC GTGAGGCAGG GGAGTCTGCT TGTCTTAGAT WO 00/09525 PCT/US99/17712 EPI-109 573 1801 GTTGGTGGTG CAGCCCCAGG ACCAAGCTTA AGGAGAGGAG AGCATCTGCT CTGAGACGGA 1861 TGGAAGGAGA GAGGTTGAGG ATGCACTGGC CTGTTCTGTA GGAGAGACTG GCCAGAGGCA 1921 GCTAAGGGGC AGGAATCAAG GAGCCTCCGT TCCCACCTCT GAGGACTCTG GACCCCAGGC 1981 CATACCAGGT GCTAGGGTGC CTGCTCTCCT TGCCCTGGGC CAGCCCAGGA TTGTACGTGG 2041 GAGAGGCAGA AAGGGTAGGT TCAGTAATCA TTTCTGATGA TTTGCTGGAG TGCTGGCTCC 2101 ACGCCCTGGG GAGTGAGCTT GGTGCGGTAG GTGCTGGCCT CAAACAGCCA CGAGGTGGTA 2161 GCTCTGAGCC CTCCTTCTTG CCCTGAGCTT TCCGGGGAGG AGCCTGGAGT GTAATTACCT 2221 GTCATCTGGG CCACCAGCTC CACTGGCCCC CGTTGCCGGG CCTGGACTGT CCTAGGTGAC 2281 CCCATCTCTG CTGCTTCTGG GCCTGATGGA GAGGAGAACA CTAGACATGC CAACTCGGGA 2341 GCATTCTGCC TGCCTGGGAA CGGGGTGGAC GAGGGAGTGT CTGTAAGGAC TCAGTGTTGA 2401 CTGTAGGCGC CCCTGGGGTG GGTTTAGCAG GCTGCAGCAG GCAGAGGAGG AGTACCCCCC 2461 TGAGAGCATG TGGGGGAAGG CCTTGCTGTC ATGTGAATCC CTCAATACCC CTAGTATCTG 2521 GCTGGGTTTT CAGGGGCTTT GGAAGCTCTG TTGCAGGTGT CCGGGGGTCT AGGACTTTAG 2581 GGATCTGGGA TCTGGGGAAG GACCAACCCA TGCCCTGCCA AGCCTGGAGC CCCTGTGTTG 2641 GGGGGCAAGG TGGGGGAGCC TGGAGCCCCT GTGTGGGAGG GCGAGGCGGG GGAGCCTGGA 2701 GCCCCTGTGT GGGAGGGCGA GGCGGGGGAT CCTGGAGCCC CTGTGTCGGG GGGCGAGGGA 2761 GGGGAGGTGG CCGTCGGTTG ACCTTCTGAA CATGAGTGTC AACTCCAGGA CTTGCTTCCA 2821 AGCCCTTCCC TCTGTTGGAA ATTGGGTGTG CCCTGGCTCC CAAGGGAGGC CCATGTGACT 2881 AATAAAAAAC TGTGAACCCT (2) INFORMATION FOR SEQ ID NO:2422: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1921 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2422: 1 CGCATTTGTG TTTTAATAAA AGAATCTGGA AGATAAATAG TCTTGAAGAG AGACAAAGGA 61 AGGAAAATTT AAATCCTTAG ATTCAAGCAG AAGAATTCCA TGTGGAAGGT TTGGGTTGTT 121 GTTGTTGTTG TTTGGTGTGT TTTTTGTTTT TTTGTTTTTT TGTTTTTTTT TGAGATGGAG 181 TCTCGCTGTG TTACCGGGAG CGACAGAGCC GCACGGCCGA GTCGAGTCCC AGCCAGCTAC 241 CATCCCTCTG GAGCTTACCG GCCGGCCTTG GCTTCCCCAG GAATCCCTGG AGCTAGCGGC 301 TGCTGAAGGC GTCGAGGTGT GGGGGCACTT GGACAGAACA GTCAGGCAGC CGGGAGCTCT 361 GCCAGCTTTG GTGACCTTGG GTGCTTGCCT CGTGCCCCTT GGTGCCCGTC TGCTGATGTG 421 CCCAGCCTGT GCCCGCCATG CCGCCCTCCA TCTCAGCTTT CCAGGCCGCC TACATCGGCA 481 TCGAGGTGCT CATCGCCCTG GTCTCTGTGC CCGGGAACGT GCTGGTGATC TGGGCGGTGA 541 AGGTGAACCA GGCGCTGCGG GATGCCACCT TCTGCTTCAT CGTGTCGCTG GCGGTGGCTG 601 ATGTGGCCGT GGGTGCCCTG GTCATCCCCC TCGCCATCCT CATCAACATT GGGCCACAGA 661 CCTACTTCCA CACCTGCCTC ATGGTTGCCT GTCCGGTCCT CATCCTCACC CAGAGCTCCA 721 TCCTGGCCCT GCTGGCAATT GCTGTGGACC GCTACCTCCG GGTCAAGATC CCTCTCCGGT 781 ACAAGATGGT GGTGACCCCC CGGAGGGCGG CGGTGGCCAT AGCCGGCTGC TGGATCCTCT 841 CCTTCGTGGT GGGACTGACC CCTATGTTTG GCTGGAACAA TCTGAGTGCG GTGGAGCGGG 901 CCTGGGCAGC CAACGGCAGC ATGGGGGAGC CCGTGATCAA GTGCGAGTTC GAGAAGGTCA 961 TCAGCATGGA GTACATGGTC TACTTCAACT TCTTTGTGTG GGTGCTGCCC CCGCTTCTCC 1021 TCATGGTCCT CATCTACCTG GAGGTCTTCT ACCTAATCCG CAAGCAGCTC AACAAGAAGG 1081 TGTCGGCCTC CTCCGGCGAC CCGCAGAAGT ACTATGGGAA GGAGCTGAAG ATCGCCAAGT 1141 CGCTGGCCCT CATCCTCTTC CTCTTTGCCC TCAGCTGGCT GCCTTTGCAC ATCCTCAACT 1201 GCATCACCCT CTTCTGCCCG TCCTGCCACA AGCCCAGCAT CCTTACCTAC ATTGCCATCT 1261 TCCTCACGCA CGGCAACTCG GCCATGAACC CCATTGTCTA TGCCTTCCGC ATCCAGAAGT 1321 TCCGCGTCAC CTTCCTTAAG ATTTGGAATG ACCATTTCCG CTGCCAGCCT GCACCTCCCA 1381 TTGACGAGGA TCTCCCAGAA GAGAGGCCTG ATGACTAGAC CCCGCCTTCC GCTCCCACCG 1441 CCCACATCCA GTGGGGTCTC AGTCCAGTCC TCACATGCCC GCTGTCCCAG GGGTCTCCCT 1501 GAGCCTGCCC CAGCTGGGCT GTTGGCTGGG GGCATGGGGG AGGCTCTGAA GAGATACCCA 1561 CAGAGTGTGG TCCCTCCACT AGGAGTTAAC TACCCTACAC CTCTGGGCCC TGCAGGAGGC 1621 CTGGGAGGGC AAGGGTCCTA CGGAGGGACC AGGTGTCTAG AGGCAACAGT GTTCTGAGCC 1681 CCCACCTGCC TGACCATCCC ATGAGCAGTC CAGAGCTTCA GGGCTGGGCA GGTCCTGGGG 1741 AGGCTGAGAC TGCAGAGGAG CCACCTGGGC TGGGAGAAGG TGCTTGGGCT TCTGCGGTGA 1801 GGCAGGGGAG TCTGCTTGTC TTAGATGTTG GTGGTGCAGC CCCAGGACCA AGCTTAAGGA 1861 GAGGAGAGCA TCTGCTCTGA GACGGATGGA AGGAGAGAGG TTGAGGATGC ACTGGCCTGT 1921 TCTGTAGGAG AGACTGGCCA GA (2) INFORMATION FOR SEQ ID NO:2423: Gi) SEQUENCE CHARACTERISTICS: (A) LENGTH: 5904 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (DC TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2423: ATGCCGCCCT CCATCTCAGC TTTCCAGGCC GCCTACATCG GCATCGAGG GCTCATCGCC CTGGTCTCTG TGCCCGGGAA CGTGCTGGTG ATCTGGGCGG TGAAGGTGAA CCAGGCGCT CGGGATGCCA CCTTCTGCTT WO 00/09525 PCT/US99/17712 EPI-109 574 CATCGTCTCG CTGGCGGTGG CTGATGTGGC CGTGGGTGCC CTGGTCATCC CCCTCGCCAT CCTCATCAAC ATTGGGCCAC AGACCTACTT CCACACCTGC CTCATGGTTG CCTGTCCCCT CCTCATCCTC ACCCAGAGCT CCATCCTGGC CCTGCTGGCA ATTGCTGTGG ACCGCTACCT CCGGGTCAAG ATCCCTCTCC GGTACAAGAT GGTGGTGACC CCCCGGAGGG CGGCGGTGGC CATAGCCGGC TCCTGGATCC TCTCCTTCGT GGTGGGACTG CCCCTATGT TTGGCTGGAA CAATCTGAGT GCGGTGGAGC GGGCCTGGGC AGCCAACGGC AGCATGGGGG AGCCCGTGAT CAAGTGCGAG TTCGAGAAGG TCATCAGCAT GGAGTACATG GTCTACTTCA ACTTCTTTGT GTGGGTGCTG CCCCCGCTTC TCCTCATGGT CCTCATCTAC CTGGAGGTCT TCTACCTAAT CCGCAAGCAG CTCAACAAGA AGGTGTCGGC CTCCTCCGGC GACCCGCAGA AGTACTATGG GAAGGAGCTG AAGATCGCCA AGTCGCTGGC CCTCATCCTC TTCCTCTTTG CCCTCAGCTG GCTGCCTTTG CACATCCTCA ACTGCATCAC CCTCTTCTGC CCGTCCTGCC ACAAGCCCAG CATCCTTACC TACATTGCCA TCTTCCTCAC GCACGGCAAC TCGGCCATGA ACCCCATTGT CTATGCCTTC CGCATCCAGA AGTTCCGCGT CACCTTCCTT AAGATTTGGA ATGACCATTT CCGCTGCCAG CCTGCACCTC CCATTGACGA GGATCTCCCA GAAGAGAGGC CTGATGACTA G ATGAGTGTCA GAAGTGTGAA GGGTGCCTGT TCTGAATCCC AGAGCCTCCT CTCCCTCTGT GAGGCTGGCA GGTGAGGAAG GGTTTAACCT CACTGGAAGG AATCCCTGGA GCTAGCGGCT GCTGAAGGCG TCGAGGTGTG GGGGCACTTG GACAGAACAG TCAGGCAGCC GGGAGCTCTG CCAGCTTTGC TGACCTTGGG CCGGGCTGGG AGCGCTGCGG CGGGAGCCGG AGGACTATGA GCTGCCGCGC GTTGTCCAGA GCCCAGCCCA GCCCTACGCG CGCCCCGG AGCTCTGTTC CCTGGAACTT TGGGCACTGC CTCTGGGACC CCTGCCGGCC AGCAGGCAGG ATGGTGCTTG CCTCGTGCCC CTTGGTGCCC GTCTGCTGAT GTGCCCAGCC TGTGCCCGCC ATGCCGCCCT CCATCTCAGC TTTCCAGGCC GCCTACATCG GCATCGAGGT GCTCATCGCC CTGGTCTCTG TGCCCGGGAA CGTGCTGGTG ATCTGGGCGG TGAAGGTGAA CCAGGCGCTG CGGGATGCCA CCTTCTGCTT CATCGTGTCG CTGGCGGTGG CTGATGTGGC CGTGGGTGCC CTGGTCATCC CCCTCGCCAT CCTCATCAAC ATTGGGCCAC AGACCTACTT CCACACCTGC CTCATGGTTG CCTGTCCGGT CCTCATCCTC ACCCAGAGCT CCATCCTGGC CCTGCTGGCA ATTGCTGTGG ACCGCTACCT CCGCTCAAG ATCCCTCTCC GGTACAAGAT GGTGGTGACC CCCCGGAGGG CGGCGGTGGC CATAGCCGGC TCCTGGATCC TCTCCTTCGT GGTGGGACTG ACCCCTATGT TTGGCTGGAA CAATCTGAGT GCGGTGGAGC GGGCCTGGGC AGCCAACGGC AGCATGGGGG AGCCCGTGAT CAAGTGCGAG TTCGAGAAGG TCATCAGCAT GGAGTACATG GTCTACTTCA ACTTCTTTGT GTGGGTGCTG CCCCCGCTTC TCCTCATGGT CCTCATCTAC CTGGAGGTCT TCTACCTAAT CCGCAAGCAG CTCAACAAGA AGGTGTCGGC CTCCTCCGGC GACCCGCAGA AGTACTATGG GAAGGAGCTG AAGATCGCCA AGTCGCTGGC CCTCATCCTC TTCCTCTTTG CCCTCAGCTG GCTGCCTTTG CACATCCTCA ACTGCATCAC CCTCTTCTGC CCGTCCTGCC ACAAGCCCAG CATCCTTACC TACATTGCCA TCTTCCTCAC GCACGGCAAC TCGGCCATGA ACCCCATTGT CTATGCCTTC CGCATCCAGA AGTTCCGCGT CACCTTCCTT AAGATTTGGA ATGACCATTT CCGCTGCCAG CCTGCACCTC CCATTGACGA GGATCTCCCA GAAGAGAGGC CTGATGACTA GACCCCGCCT TCCGCTCCCA CCAGCCCACA TCCAGTGGGG TCTCAGTCCA GTCCTCACAT GCCCGCTGTC CCAGGGGTCT CCCTGAGCCT GCCCCAGCTG GGCTGTTGGC TGGGGGCATG GGGGAGGCTC TGAAGAGATA CCCACAGAGT GTGGTCCCTC CACTAGGAGT TAACTACCCT ACACCTCTGG GCCCTGCAGG AGGCCTGGGA CGGCAAGGGT CCTACGGAGG GACCAGGTGT CTAGAGGCAA CAGTGTTCTG AGCCCCCACC TGCCTGACCA TCCCATGAGC AGTCCAGCGC TTCAGGGCTG GGCAGGTCCT GGGGAGGCTG AGACTGCAGA GGAGCCACCT GGGCTGGGAG AAGGTGCTTG GGCTTCTGCG GTGAGGCAGG GGAGTCTGCT TGTCTTAGAT GTTGGTGGTC CAGCCCCAGG ACCAAGCTTA AGGAGAGGAG AGCATCTGCT CTGAGACGGA TGGAAGGAGA GAGGTTGAGG ATGCACTGGC CTGTTCTGTA GGAGAGACTG GCCAGAGGCA GCTAAGGGGC AGGAATCAAG GAGCCTCCGT TCCCACCTCT GAGGACTCTG GACCCCAGGC CATACCAGGT GCTAGGGTGC CTGCTCTCCT TGCCCTGGGC CAGCCCAGGA TTGTACGTGG GAGAGGCAGA AAGGGTAGGT TCAGTAATCA TTTCTGATGA TTTGCTGGAG TGCTGGCTCC ACGCCCTGGG GAGTGAGCTT GGTGCGGTAG GTGCTGGCCT CAAACAGCCA CGAGGTGGTA GCTCTGAGCC CTCCTTCTTG CCCTGAGCTT TCCGGGGAGG AGCCTGGAGT GTAATTACCT GTCATCTGGG CCACCAGCTC CACTGGCCCC CGTTGCCGGG CCTGGACTGT CCTAGGTGAC CCCATCTCTG CTGCTTCTGG GCCTGATGGA GAGGAGAACA CTAGACATGC CAACTCGGGA GCATTCTGCC TGCCTGGGAA CGGGGTGGAC GAGGGAGTGT CTGTAAGGAC TCAGTGTTGA CTGTAGGCGC CCCTGGGGTG GGTTTAGCAG GCTGCAGCAG GCAGAGGAGG AGTACCCCCC TGAGAGCATG TGGGGGAAGG CCTTGCTGTC ATGTGAATCC CTCAATACCC CTAGTATCTG GCTGGGTTTT CAGGGGCTTT GGAAGCTCTG TTGCAGGTGT CCGGGGGTCT AGGACTTTAG GGATCTGGGA TCTGGGGAAG GACCAACCCA TGCCCTGCCA AGCCTGGAGC CCCTGTGTTG GGGGGCAAGG TGGGGGAGCC TGGAGCCCCT GTGTGGGAGG GCGAGGCGGG GGAGCCTGGA GCCCCTGTGT GGGAGGGCGA GGCGGGGGAT CCTGGAGCCC CTGTGTCGGG GGGCGAGGGA GGGGAGGTGG CCGTCGGTTG ACCTTCTGAA CATGAGTGTC AACTCCAGGA CTTGCTTCCA AGCCCTTCCC TCTGTTGGAA ATTGGGTGTG CCCTGGCTCC CAAGGGAGGC CCATGTGACT AATAAAAAAC TGTGAACCCT CGCATTTGTG TTTTAATAAA AGAATCTGGA AGATAAATAG TCTTGAAGAG AGACAAAGGA AGGAAAATTT AAATCCTTAG ATTCAAGCAG AAGAATTCCA TGTGGAAGGT TTGGGTTGTT GTTGTTGTTG TTTGGTGTGT TTTTTGTTTT TTTGTTTTTT TGTTTTTTTT TGAGATGGAG TCTCGCTGTG TTACCGGGAG CGACAGAGCC GCACGGCCGA GTCGAGTCCC AGCCAGCTAC CATCCCTCTG GAGCTTACCG GCCGGCCTTG GCTTCCCCAG GAATCCCTGG AGCTAGCGGC TGCTGAAGGC GTCGAGGTGT GGGGGCACTT GGACAGAACA GTCAGGCAGC CGGGAGCTCT GCCAGCTTTG GTGACCTTGG GTGCTTGCCT CGTGCCCCTT GGTGCCCGTC TGCTGATGTG CCCAGCCTGT GCCCGCCATG CCGCCCTCCA TCTCAGCTTT CCAGGCCGCC TACATCGGCA TCGAGGTGCT CATCGCCCTG GTCTCTGTGC CCGGGAACGT GCTGGTGATC TGGGCGGTGA AGGTGAACCA GGCGCTGCGG GATGCCACCT TCTGCTTCAT CGTGTCGCTG GCGGTGGCTG ATGTGGCCGT GGGTGCCCTG GTCATCCCCC TCGCCATCCT CATCAACATT GGGCCACAGA CCTACTTCCA CACCTGCCTC ATGGTTGCCT GTCCGGTCCT CATCCTCACC CAGAGCTCCA TCCTGGCCCT GCTGGCAATT GCTGTGGACC GCTACCTCCG GGTCAAGATC CCTCTCCGGT ACAAGATGGT GGTGACCCCC CGGAGGGCGG CGGTGGCCAT AGCCGGCTGC TGGATCCTCT CCTTCGTGGT GGGACTGACC CCTATGTTTG GCTGGAACAA TCTGAGTGCG GTGGAGCGGG CCTGGGCAGC CAACGGCAGC ATGGGGGAGC CCGTGATCAA GTGCGAGTTC GAGAAGGTCA TCAGCATGGA GTACATGGTC TACTTCAACT TCTTTGTGTG GGTGCTGCCC CCGCTTCTCC TCATGGTCCT WO 00/09525 PCT/US99/17712 EPI-109 575 CATCTACCTG GAGGTCTTCT ACCTAATCCG CAAGCAGCTC AACAAGAAGG TGTCGGCCTC CTCCGGCGAC CCGCAGAAGT ACTATGGGAA GGAGCTGAAG ATCGCCAAGT CGCTGGCCCT CATCCTCTTC CTCTTTGCCC TCAGCTGGCT GCCTTTGCAC ATCCTCAACT GCATCACCCT CTTCTGCCCG TCCTGCCACA AGCCCAGCAT CCTTACCTAC ATTGCCATCT TCCTCACGCA CGGCAACTCG GCCATGAACC CCATTGTCTA TGCCTTCCGC ATCCAGAAGT TCCGCGTCAC CTTCCTTAAG ATTTGGAATG ACCATTTCCG CTGCCAGCCT GCACCTCCCA TTGACGAGGA TCTCCCAGAA GAGAGGCCTG ATGACTAGAC CCCGCCTTCC GCTCCCACCG CCCACATCCA GTGGGGTCTC AGTCCAGTCC TCACATGCCC GCTGTCCCAG GGGTCTCCCT GAGCCTGCCC CAGCTGGGCT GTTGGCTGGG GGCATGGGGG AGGCTCTGAA GAGATACCCA CAGAGTGTGG TCCCTCCACT AGGAGTTAAC TACCCTACAC CTCTGGGCCC TGCAGGAGGC CTGGGAGGGC AAGGGTCCTA CGGAGGGACC AGGTGTCTAG AGGCAACAGT GTTCTGAGCC CCCACCTGCC TGACCATCCC ATGAGCAGTC CAGAGCTTCA GGGCTGGGCA GGTCCTGGGG AGGCTGAGAC TGCAGAGGAG CCACCTGGGC TGGGAGAAGG TGCTTGGGCT TCTGCGGTGA GGCAGGGGAG TCTGCTTGTC TTAGATGTTG GTGGTGCAGC CCCAGGACCA AGCTTAAGGA GAGGAGAGCA TCTGCTCTGA GACGGATGGA AGGAGAGAGG TTGAGGATGC ACTGGCCTGT TCTGTAGGAG AGACTGGCCA GA GAT GGA GGG CGG CAT GGC GGG G CGG GTC GCC GG GGC GGG CBC BGG C GGC GGG CBC GC GGC CTG G GGB GGG CGG C GBT GGB GGG GG CTG GGC GC GGC CTG GAA AGC TGA GAT GGA GGG CGG CAT GGC GGG CAC AGG CTG GGC 5904 (2) INFORMATION FOR SEQ ID NO:2424: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1681 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2424: 1 CCCAGCCCCG AGGCTCAGAA GCGGCAGGCG GAGGCGCGGT CCGGGCGCTA TGGCCATGCC 61 CGGCGGGTCT CACGCGGCTG CCCCTCGCCC GGCGCGCCTT CGGTAGGGGG CGCCCGGGGC 121 CCAGCTGGCC CGGCCATGCT GCTGGAGACA CAGGACGCGC TGTACGTGGC GCTGGAGCTG 181 GTCATCGCCG CGCTTTCGGT GGCGGGCAAC GTGCTGGTGT GCGCCGCGGT GGGCACGGCG 241 AACACTCTGC AGACGCCCAC CAACTACTTC CTGGTGTCCC TGGCTGCGGC CGACGTGGCC 301 GTGGGGCTCT TCGCCATCCC CTTTGCCATC ACCATCAGCC TGGGCTTCTG CACTGACTTC 361 TACGGCTGCC TCTTCCTCGC CTGCTTCGTG CTGGTGCTCA CGCAGAGCTC CATCTTCAGC 421 CTTCTGGCCG TGGCAGTCGA CAGATACCTG GCCATCTGTG TCCCGCTCAG GTATAAAAGT 481 TTGGTCACGG GGACCCGAGC AAGAGGGGTC ATTGCTGTCC TCTGGGTCCT TGCCTTTGGC 541 ATCGGATTGA CTCCATTCCT GGGGTGGAAC AGTAAAGACA GTGCCACCAA CAACTGCACA 601 GAACCCTGGG ATGGAACCAC GAATGAAAGC TGCTGCCTTG TGAAGTGTCT CTTTGAGAAT 661 GTGGTCCCCA TGAGCTACAT GGTATATTTC AATTTCTTTG GGTGTGTTCT GCCCCCACTG 721 CTTATAATGC TGGTGATCTA CATTAAGATC TTCCTGGTGG CCTGCAGGCA GCTTCAGCGC 781 ACTGAGCTGA TGGACCACTC GAGGACCACC CTCCAGCGGG AGATCCATGC AGCCAAGTCA 841 CTGGCCATGA TTGTGGGGAT TTTTGCCCTG TGCTGGTTAC CTGTGCATGC TGTTAACTGT 901 GTCACTCTTT TCCAGCCAGC TCAGGGTAAA AATAAGCCCA AGTGGGCAAT GAATATGGCC 961 ATTCTTCTGT CACATGCCAA TTCAGTTGTC AATCCCATTG TCTATGCTTA CCGGAACCGA 1021 GACTTCCGCT ACACTTTTCA CAAAATTATC TCCAGGTATC TTCTCTGCCA AGCAGATGTC 1081 AAGAGTGGGA ATGGTCAGGC TGGGGTACAG CCTGCTCTCG GTGTGGGCCT ATGATCTAGG 1141 CTCTCGCCTC TTCCAGGAGA AGATACAAAT CCACAAGAAA CAAAGAGGAC ACGGCTGGTT 1201 TTCATTGTGA AAGATAGCTA CACCTCACAA GGAAATGGAC TGCCTCTCTT GAGCACTTCC 1261 CTGGAGCTAC CACGTATCTA GCTAATATGT ATGTGTCAGT AGTAGCACCA AGGATTGACA 1321 AATATATTTA TGATCTATTC AGCTGCTTTT ACTGTGTGGA TTATGCCAAC AGCTTGAATG 1381 GATTCTAACA GACTCTTTTG TTTTTAAAAG TCTGCCTTGT TTATGGTGGA AAATTACTGA 1441 AACTATTTTA CTGTGAAACA GTGTGAACTA TTATAATGCA AATACTTTTT AACTTAGAGG 1501 CAATGGAAAA ATAAAAGTTG ACTGTACTAA AAATGTATAC TTGTTGCCAG GAAGGTGACC 1561 TCAAAAATTA AAAGTATAAT TATTCGGCCG GGCATGGTGG CTCACACCTG TAATTCCAGC 1621 ACTTTGGGAG GCCAAGGCAG GCGGATCACG AGGTCAGGAG TTCAAAACCA GCCTGTCCAA 1681 TATAGTG (2) INFORMATION FOR SEQ ID NO:2425: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1681 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2425: 1 GGGCAATTTG TTAGTTATCC GCCGCCACCA AGACGCGGCA CGGCGCCTGG ACCGGAGGGG 61 CCCCGCGCGG GCGCGAACTT TGGGCTCGGG CGAGTGGGTG GTGCTCCGCC CAGCCCGAGA 121 CGGGCGGGCG CGCGGGCCAA TGGGTGCCGC CTCTTGGCCG CGGGGGGCCC CGACCCGTGG 181 GTCCCGGCCA CCAGCGCCCC AGCCCCGAGG CTCAGAAGCG GCAGGCGGAG GCGCGGTCCG 241 GGCGCTATGG CCATGCCCGG CGGGTCTCAC GCGGCTGCCC CTCGCCCGGC GCGCCTTCGG 301 TAGGGGGCGC CCGGGGCCCA GCTGGCCCGG CCATGCTGCT GGAGACACAG GACGCGCTGT 361 ACGTGGCGCT GGAGCTGGTC ATCGCCGCGC TTTCGGTGGC GGGCAACGTG CTGGTGTGCG 421 CCGCGGTGGG CACGGCGAAC ACTCTGCAGA CGCCCACCAA CTACTTCCTG GTGTCCCTGG WO 00/09525 PCT/US99/17712 EPI-109 576 481 CTGCGGCCGA CGTGGCCGTG GGGCTCTTCG CCATCCCCTT TGCCATCACC ATCAGCCTGG 541 GCTTCTGCAC TGACTTCTAC GGCTGCCTCT TCCTCGCCTG CTTCGTGCTG GTGCTCACGC 601 AGAGCTCCAT CTTCAGCCTT CTGGCCGTGG CAGTCGACAG ATACCTGGCC ATCTGTGTCC 661 CGCTCAGGTA TAAAAGTTTG GTCACGGGGA CCCGAGCAAG AGGGGTCATT GCTGTCCTCT 721 GGGTCCTTGC CTTTGGCATC GGATTGACTC CATTCCTGGG GTGGAACAGT AAAGACAGTG 781 CCACCAACAA CTGCACAGAA CCCTGGGATG GAACCACGAA TGAAAGCTGC TGCCTTGTGA 841 AGTGTCTCTT TGAGAATGTG GTCCCCATGA GCTACATGGT ATATTTCAAT TTCTTTGGGT 901 GTGTTCTGCC CCCACTGCTT ATAATGCTGG TGATCTACAT TAAGATCTTC CTGGTGGCCT 961 GCAGGCAGCT TCAGCGCACT GAGCTGATGG ACCACTCGAG GACCACCCTC CAGCGGGAGA 1021 TCCATGCAGC CAAGTCACTG GCCATGATTG TGGGGATTTT TGCCCTGTGC TGGTTACCTG 1081 TGCATGCTGT TAACTGTGTC ACTCTTTTCC AGCCAGCTCA GGGTAAAAAT AAGCCCAAGT 1141 GGGCAATGAA TATGGCCATT CTTCTGTCAC ATGCCAATTC AGTTGTCAAT CCCATTGTCT 1201 ATGCTTACCG GAACCGAGAC TTCCGCTACA CTTTTCACAA AATTATCTCC AGGTATCTTC 1261 TCTGCCAAGC AGATGTCAAG AGTGGGAATG GTCAGGCTGG GGTACAGCCT GCTCTCGGTG 1321 TGGGCCTATG ATCTAGGCTC TCGCCTCTTC CAGGAGAAGA TACAAATCCA CAAGAAACAA 1381 AGAGGACACG GCTGGTTTTC ATTGTGAAAG ATAGCTACAC CTCACAAGGA AATGGACTGC 1441 CTCTCTTGAG CACTTCCCTG GAGCTACCAC GTATCTAGCT AATATGTATG TGTCAGTAGT 1501 AGGCTCCAAG GATTGACAAA TATATTTATG ATCTATTCAG CTGCTTTTAC TGTGTGGATT 1561 ATGCCAACAG CTTGAATGGA TTCTAACAGA CTCTTTTGTT TTTAAAAGTC TGCCTTGTTT 1621 ATGGTGGAAA ATTACTGAAA CTATTTTACT GTGAAACAGT GTGAACTATT ATAATGCAAA 1681 TACTTTTTAA CTTAGAGGCA ATGGAAAAAT AAAAGTTGAC TGTACTAAAA ATG (2) INFORMATION FOR SEQ ID NO:2426: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 2461 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2426: 1 GAATTCCCAG ATGGGCAGAG GTGGCTGGGC TGGTGACCCT AAGTGTGTCT CCTGCCTTTA 61 TTCTCTCTAG TGGGTTATTC TTTCATGTGG TATCTTGCCT ACAGCATGCT GTGTTTGGAC 121 ACAAACCCCT TTCCTTGGTT TCTCTGACCC AGCTGAGATG GACTGATTCC AAAAGAACTC 181 ACCTATGTAC TGGGGTAGGG GAGGGAGGGT TTTTTGCAGT ATTTAACTAA GGTTCAAAGA 241 GTGCTATATA GTGAGAAAGG CTTCTTTTTT TTTTTTTTTT TTTTTTGGCA GAGTGCTGCC 301 TCCTAGAAAT TTCTCTTGGT AACTTCCTTC TCTGAAGCAC AGATAAAGAA AACAATTACA 361 GTAGAAACAT TTATGAGGGA CACATTGGAG GCCGATGAAG CTTTTCAAGT TCCAGCAGTG 421 CAGGGATGTG GGCAGAACTG ACATTGGAAA ATACTAGAAT GATGGAAATT CAGTTGGAGA 481 GGACTGCCCT TTTTAATGTC TGGGGAGTCT GCTCAGGGAG AAATGACAAG TCTGGCGGGG 541 ACAAGTATGG GATTTGGTAA GACTTGGATC AACTTGGGAT ACAGGGTGGG GGTCGGGAGT 601 GGAATCAATG AATGATGCCA GAGCAGATCA ACTAACAAGA GGACCCTGAT GAGCCCCAGG 661 CAGAGGCGTC TCCCTTATGC CCCACTCTGA AGTGTTTGTT AGTAAACACC AGAACGCCAT 721 TGTTGTTACT GCTGAATTTT ATTTTGGGCT GTACATATTT AGATGCTTAA GGTAAAAATG 781 ATAAAGCCCT CAAGCCACTG TGTGGGTTTG GGTCCAAGTG TTCCTTCTTG CTGCCTCTCT 841 AACACGCCTG GTTAAAATAA TCCCTTTGGA TGGTGCTGAG AAGCACCTGA ACCAAGTGGG 901 TCCCCAAATA ACAATGGCGT GCAAGTGTCT GGTTCCCAGA AGTTGGTGAC TAGGTAAGCA 961 GCTTCAGGGA GAGGGGGCTG ATTCCCAGAC AGTCGCCTGT TCCTGCGGGG ATGGGGCTGA 1021 GGCTTGGGGA ATGTGGGCAG GAGGATATGC CATTTGATTC TGTTGCACAC GTTCTTTTCC 1081 CTTCTTTCTG TATGTCTGGT CATTCTGCTA TTCTGTCGTT CCTCACATAG GTTGGACATT 1141 GGCCGGCTGC CAGCATAAGT GCCAGTGTGA TTTTGCTAGG TGTGAGCTGA GAAAGAGAGG 1201 TGGAGGCTAA GCAGGTGTGA TGCTTCTCAG AGGTGCTGAG TTTTTGCCCT TCTGAGCAGG 1261 GAATCTTTGC TTATCCCTTT GACCAAGGAT CTTTGCTGCA AAGGCTGGGT ATCGGCTGTG 1321 CTCAGCAAAG CGTCAACTCG TGCAAGAACT TAGCAGGAAT AGTTCTGGCT AAGGTTAGGA 1381 GGCTGCCACC AAAGTCTCTT TTTTGTTCCT CTGCTTCTCC CGTTTGCCTC CTTATCATGA 1441 GATCTTTTTG CTAAGCTGGC AGAAAGATTG CATAGTCAGT GCTTCCAGCT CTGCTCCCAC 1501 CTGATCCTGC ACTGTCCTCT GGTCCCTGAA TGAATGAACT CTGATACCCA ATCTTGTCTC 1561 GAGCCTTCTC TATGCCACTC ATGGCTCCTC TTCTGCTCTT TCCATCTTTT TGCTGAGAGT 1621 TCTGAGCTCT GTACTTCCTC TTGGCCCATC TCACTTCCTG AAACACCCCT GAAGAGGGTT 1681 GCTTATCTTG ATGGAACTCA AAAAGCCAAA AAGCTGCAGG CAGAGGCGTT GAGGACATCT 1741 GTTTGGGGAA CTAAGAGCAG CAGCACTTTC AGATTCAGTC CATATAGAGC TGTCCTACAG 1801 CATTCTGGAA ACTTGAGGAT GTGCGGTGCA TAAAGGGGCT GGAAGTGACC CACCTGTGAT 1861 GAGCCCTTTC TAAGGAGAAG GGTTTCCAAG AGATCACCCC ACCAGAAAAG GGTAGGAATG 1921 AGCAAGTTGG GAATTTTAGA CTGTCACTGC ACATGGACCT CTGGGAAGAC GTCTGGCGAG 1981 AGCTAGGCCC ACTGGCCCTA CAGACGGATC TTGCTGGCTC ACCTGTCCCT GTGGAGGTTC 2041 CCCTGGGAAG GCAAGATGCC CAACAACAGC ACTGCTCTGT CATTGGCCAA TGTTACCTAC 2101 ATCACCATGG AAATTTTCAT TGGACTCTGC GCCATAGTGG GCAACGTGCT GGTCATCTGC 2161 GTGGTCAAGC TGAACCCCAG CCTGCAGACC ACCACCTTCT ATTTCATTGT CTCTCTAGCC 2221 CTGGCTGACA TTGCTGTTGG GGTGCTGGTC ATGCCTTTGG CCATTGTTGT CAGCCTGGGC 2281 ATCACAATCC ACTTCTACAG CTGCCTTTTT ATGACTTGCC TACTGCTTAT CTTTACCCAC 2341 GCCTCCATCA TGTCCTTGCT GGCCATCGCT GTGGACCGAT ACTTGCGGGT CAAGCTTACC WO 00/09525 PCT/US99/17712 EPI-109 577 2401 GTCAGGTAGC CTGCGGCGTG GGGTGGGCAG CAATTGAGGC AGCTGGGAAA TGAGGCTACA 2461 AAGCCAGAGC (2) INFORMATION FOR SEQ ID NO:2427: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1741 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2427: 1 CGAATTCGGG GGACATCTGT TTGGGGAACT AAGAGCAGCA GCACTTTCAG ATTCAGTCCA 61 TATAGAGCTG TCCTACAGCA TTCTGGAAAC TTGAGGATGT GCGGTGCATA AACGGGCTGG 121 AAGTGACCCA CCTGTGATGA GCCCTTTCTA AGGAGAAGGG TTTCCAAGAG ATCACCCCAC 181 CAGAAAAGGG TAGGAATGAG CAAGTTGGGA ATTTTAGACT GTCACTGCAC ATGGACCTCT 241 GGGAAGACGT CTGGCGAGAG CTAGGCCCAC TGGCCCTACA GACGGATCTT GCTGGCTCAC 301 CTGTCCCTGT GGAGGTTCCC CTGGGAAGGC AAGATGCCCA ACAACAGCAC TGCTCTGTCA 361 TTGGCCAATG TTACCTACAT CACCATGGAA ATTTTCATTG GACTCTGCGC CATAGTGGGC 421 AACGTGCTGG TCATCTGCGT GGTCAAGCTG AACCCCAGCC TGCAGACCAC CACCTTCTAT 481 TTCATTGTCT CTCTAGCCCT GGCTGACATT GCTGTTGGGG TGCTGGTCAT GCCTTTGGCC 541 ATTGTTGTCA GCCTGGGCAT CACAATCCAC TTCTACAGCT GCCTTTTTAT GACTTGCCTA 601 CTGCTTATCT TTACCCACGC CTCCATCATG TCCTTGCTGG CCATCGCTGT GGACCGATAC 661 TTGCGGGTCA AGCTTACCGT CAGATACAAG AGGGTCACCA CTCACAGAAG AATATGGCTG 721 GCCCTGGGCC TTTGCTGGCT GGTGTCATTC CTGGTGGGAT TGACCCCCAT GTTTGGCTGG 781 AACATGAAAC TGACCTCAGA GTACCACAGA AATGTCACCT TCCTTTCATG CCAATTTGTT 841 TCCGTCATGA GGATGGACTA CATGGTATAC TTCAGCTTCC TCACCTGGAT TTTCATCCCC 901 CTGGTTGTCA TGTGCGCCAT CTATCTTGAC ATCTTTTACA TCATTCGGAA CAAACTCAGT 961 CTGAACTTAT CTAACTCCAA AGAGACAGGT GCATTTTATG GACGGGAGTT CAAGACGGCT 1021 AAGTCCTTGT TTCTGGTTCT TTTCTTGTTT GCTCTGTCAT GGCTGCCTTT ATCTCTCATC 1081 AACTGCATCA TCTACTTTAA TGGTGAGGTA CCACAGCTTG TGCTGTACAT GGGCATCCTG 1141 CTGTCCCATG CCAACTCCAT GATGAACCCT ATCGTCTATG CCTATAAAAT AAAGAAGTTC 1201 AAGGAAACCT ACCTTTTGAT CCTCAAAGCC TGTGTGGTCT GCCATCCCTC TGATTCTTTG 1261 GACACAAGCA TTGAGAAGAA TTCTGAGTAG TTATCCATCA GAGATGACTC TGTCTCATTG 1321 ACCTTCAGAT TCCCCATCAA CAAACACTTG AGGGCCTGTA TGCCTGGGCC AAGGGATTTT 1381 TACATCCTTG ATTACTTCCA CTGAGGTGGG AGCATCTCCA GTGCTCCCCA ATTATATCTC 1441 CCCCACTCCA CTACTCTCTT CCTCCACTTC ATTTTTCCTT TGTCCTTTCT CTCTAATTCA 1501 GTGTTTTGGA GGCCTGACTT GGGGACAACG TATTATTGAT ATTATTGTCT GTTTTCCTTC 1561 TTCCCAATAG AAGAATAAGT CATGGAGCCT GAAGGGTGCC TAGTTGACTT ACTGACAAAA 1621 GGCTCTAGTT GGGCTGAACA TGTGTGTGGT GGTGACTCAT TTCCATGCCA TTGTGGAATT 1681 GAGCAGAGAA CCTGCTCTCG GAGGATGCCT AGGAGATGTT GGGAACAGAA GAAATAAACT 1741 GAGTTTAAGG GGGACTTAAA CTGCTGAATT C (2) INFORMATION FOR SEQ ID NO:2428: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 2041 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2428: 1 GCCGCCGCCG CCAAGATGGC GGACCTGGAG GCGGTGCTGG CCGACGTGAG CTACCTGATG 61 GCCATGGAGA AGAGCAAGGC CACGCCGGCC GCGCGCGCCA GCAAGAAGAT ACTGCTGCCC 121 GAGCCCAGCA TCCGCAGTGT CATGCAGAAG TACCTGGAGG ACCGGGGCGA GGTGACCTTT 181 GAGAAGATCT TTTCCCAGAA GCTGGGGTAC CTGCTCTTCC GAGACTTCTG CCTGAACCAC 241 CTGGAGGAGG CCAGGCCCTT GGTGGAATTC TATGAGGAGA TCAAGAAGTA CGAGAAGCTG 301 GAGACGGAGG AGGAGCGTGT GGCCCGCAGC CGGGAGATCT TCGACTCATA CATCATGAAG 361 GAGCTGCTGG CCTGCTCGCA TCCCTTCTCG AAGAGTGCCA CTGAGCATGT CCAAGGCCAC 421 CTGGGGAAGA AGCAGGTGCC TCCGGATCTC TTCCAGCCAT ACATCGAAGA GATTTGTCAA 481 AACCTCCGAG GGGACGTGTT CCAGAAATTC ATTGAGAGCG ATAAGTTCAC ACGGTTTTGC 541 CAGTGGAAGA ATGTGGAGCT CAACATCCAC CTGACCATGA ATGACTTCAG CGTGCATCGC 601 ATCATTGGGC GCGGGGGCTT TGGCGAGGTC TATGGGTGCC GGAAGGCTGA CACAGGCAAG 661 ATGTACGCCA TGAAGTGCCT GGACAAAAAG CGCATCAAGA TGAAGCAGGG GGAGACCCTG 721 GCCCTGAACG AGCGCATCAT GCTCTCGCTC GTCAGCACTG GGGACTGCCC ATTCATTGTC 781 TGCATGTCAT ACGCGTTCCA CACGCCAGAC AAGCTCAGCT TCATCCTGGA CCTCATGAAC 841 GGTGGGGACC TGCACTACCA CCTCTCCCAG CACGGGGTCT TCTCAGAGGC TGACATGCGC 901 TTCTATGCGG CCGAGATCAT CCTGGGCCTG GAGCACATGC ACAACCGCTT CGTGGTCTAC 961 CGGGACCTGA AGCCAGCCAA CATCCTTCTG GACGAGCATG GCCACGTGCG GATCTCGGAC 1021 CTGGGCCTGG CCTGTGACTT CTCCAAGAAG AAGCCCCATG CCAGCGTGGG CACCCACGGG 1081 TACATGGCTC CGGAGGTCCT GCAGAAGGGC GTGGCCTACG ACAGCAGTGC CGACTGGTTC 1141 TCTCTGGGGT GCATGCTCTT CAAGTTGCTG CGGGGGCACA GCCCCTTCCG GCAGCACAAG 1201 ACCAAAGACA AGCATGAGAT CGACCGCATG ACGCTGACGA TGGCCGTGGA GCTGCCCGAC WO 00/09525 PCT/US99/17712 EPI-109 578 1261 TCCTTCTCCC CTGAACTACG CTCCCTGCTG GAGGGGTTGC TGCAGAGGGA TGTCAACCGG 1321 AGATTGGGCT GCCTGGGCCG AGGGGCTCAG GAGGTGAAAG AGAGCCCCTT TTTCCGCTCC 1381 CTGGACTGGC AGATGGTCTT CTTGCAGAAG TACCCTCCCC CGCTGATCCC CCCACGAGGG 1441 GAGGTGAACG CGGCCGACGC CTTCGACATT GGCTCCTTCG ATGAGGAGGA CACAAAAGGA 1501 ATCAAGTTAC TGGACAGTGA TCAGGAGCTC TACCGCAACT TCCCCCTCAC CATCTCGGAG 1561 CGGTGGCAGC AGGAGGTGGC AGAGACTGTC TTCGACACCA TCAACGCTGA GACAGACCGG 1621 CTGGAGGCTC GCAAGAAAGC CAAGAACAAG CAGCTGGGCC ATGAGGAAGA CTACGCCCTG 1681 GGCAAGGACT GCATCATGCA TGGCTACATG TCCAAGATGG GCAACCCCTT CCTGACCCAG 1741 TGGCAGCGGC GGTACTTCTA CCTGTTCCCC AACCGCCTCG AGTGGCGGGG CGAGGGCGAG 1801 GCCCCGCAGA GCCTGCTGAC CATGGAGGAG ATCCAGTCGG TGGAGGAGAC GCAGATCAAG 1861 GAGCGCAAGT GCCTGCTCCT CAAGATCCGC GGTGGGAAAC AGTTCATTTT GCAGTGCGAT 1921 AGCGACCCTG AGCTGGTGCA GTGGAAGAAG GAGCTGCGCG ACGCCTACCG CGAGGCCCAG 1981 CAGCTGGTGC AGCGGGTGCC CAAGATGAAG AACAAGCCGC GCTCGCCCGT GGTGGAGCTG 2041 AGCAAGGTGC CGCTGGTCCA GCGCGGCAGT GCCAACGGCC TCTGACCCGC CCACCCGCCT (2) INFORMATION FOR SEQ ID NO:2429: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 2341 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2429: 1 CCAGGAAGCT ACCTGGAGGA GGTGAGTCTT AGCGGATGAG TAGGAGTTGT CCACGGAGGA 61 AGGTACACAG AAGGGCTTCC AGGCCCAGGA AACAGCAGAG GCACAGAAGT GAGAATGGGT 121 GGGTGAGTTG GTGGGGAAAC TCCAGGTGCA GAGGATGGTA GCGAAACAAA CTGGAGCATT 181 AAGGTCCAAG TCCTCCAAGA TCTTGACTTG CAGATTAAGG AGTTTGTTCA CCTAATCTGC 241 TTTGGGCAGA GTGTGGTGAG TCCTAGAGAC CCCTCTAGGT CTCTCCTCTC AGTAGCCCCA 301 GAAGGCCTGG AGAGCTGCTT CTGGGTGCCA AGCAGGCAGT GACTCCATCA GATCTAGATT 361 TGGGAAAAGC ATCCCTGGTC AGGGCCTGCA TCAGGGCAGT GGCTGGCCAT GAGGACCCTG 421 AGAAGTAGAC AGATTCACGG AGATTCTCAG GAGGCCAGAC AGGAGACTAT GGTGACAAAT 481 TAGATTAGAG AAGGGGAGAG AATGAAGGAG CAGTTGGGGT AAAAGAAAAC TGAGGCTGAC 541 ATGGGTATAT GGGTGGCGAG TGACTCACCA CCCACTGAGA GGAGAACCTC ACAAGCTCTG 601 ACATGCTCTG GTTCCAGGTT CTGTTGGGGC TGATCCAAGA TGGTAGCCTA GAGGTGCACA 661 GAGATGGGGG CCTTGCTTTG CAAAAGGATG CTGGCTGCTG GCCCACAGCA TGGTAATGAG 721 ATTTGAGCTT TATGTGCCCA GGGCTGGGAG GAGGGTCCTG TCACTTTGAA AGCAAAGAGA 781 GGCTCTAGAG AGGGGCATGT TGAGATAGGA ATGCTGCCTT GAGACACCTG GCTTTCCCCA 841 CTCTGGGTGG CTCTCAGCAG GGTGGGTTTC CCCTGCCAGG CAGCACTGAA CCTCTGTGCG 901 CTTCCGGCTG GGAGAGTTTT TACCGTAACT ACATGTGGAA CCATCCTGAA GGAACATCTG 961 GATGGGATGG GGTACAGGGA AGGGAGCTGC CAAGAGTGCT GGCCAGGGAC CTGGGTCTAT 1021 GAGCTGGTTG GGGGGTGGGG TTGGGTGCAG GGTACTTGAT CCTGAGTGGG CCTTCTGCGG 1081 CCAGGATTGG TTCTAGAGTA GGAGGGGTGG GATCGGGGAT GGGGGAAGCC TGTAACTGCG 1141 CTGCAGTTGT CAGGTCCCAG GTTCTGGGTG ACCTACTAAG GATTCTGGGT CCAGTGTGGG 1201 TCCCAGGTTA GACGTCCTAG TCCTGAGTCC GTGTCCACAG TTCTGGGTGT TGAGTCTAGG 1261 ACAGTGATCT GGAGTTGACA GTCCAATCTA GGTCTGAGTC CTGACCCCAA GTCTAGAGTT 1321 CAGGGTCATG GTAGTAGCCT AGGGTCAGAA TCAAGGTTGG GGTCAGTAAC CAGGATGGGA 1381 TCGAGGTCAT GGTCCAAAAT CTGGATCTGG GGACCTGTTG GGGGTCTGAG GTGAGTGTCG 1441 CAGTCTGGGT ATGGCGTTGG AGACCCAGGG CTGTGATCTG AGGTCATGGT TAGAGTCTCA 1501 GGTGGTGGGC CAAGGTTTGA GTCTGGGGTC CTGTTTGGAG TCTGGTGTCA GGTCGTGGAC 1561 TGCGTCCAAG GTCAGGGAGT CCGGGGTTAT AGCCAGGGTC TGAGATGAAA GTCCCAGATG 1621 GTGTTCAGAG GTCTGAATCT GTGTCTTGGT GAGCGTCCAG GTTCCCTGTG ATCACGTTTG 1681 GTGTCAGGGC TGCGGCCCGA CTGGGGAGCC TGGGATCCAG AGATGTGACC CGAGGTTGTG 1741 GTCAGAGAAT GGGTCTCGGG TCGTCTTCGT GCCGGGTCCC TGTCGTGTTC CAGGCCCGGG 1801 TCTCCGTCCA GCATCGAGGG CCGAGGTCAC GGCCAGGGTC TGAGCCCGCG GTCGCAGGTC 1861 TGGTTCGGGG TCAGATTCCG CGCGGCCTCC AGGGGGCGCC GTCGCCGCCC GGCTCGGCCC 1921 CTCGCGGGCT CGCTGGCGTT GTGCGCGGCA GGCGGGGCCG GAGGCGGCGG CGGCTCCGGG 1981 GGCGCGGGCC GGGCGGCGGC GGCGGCGGCG CCCCGACTGC AGTCCCGGCG GGAGCGGAGC 2041 GCGAAGCGCG GGGCCGGGCC CGGAGCCGGC GCCATGGGGC GGCGCCGCCT GTGAGCGGCG 2101 GCGAGCGGAG CCGCGGGCGC CGAGCAGGGC CAGGCGGGAG CGTCGGCGCC CGAGGCCGAG 2161 CGAGCCGCGG CCGGGCCGGG CCGAGCGCCG AGCGAGCAGG AGCGGCGGCG GCGGCGGCGG 2221 .CGGCGGGAGG AGGCAGCGCC GCCGCCAAGA TGGCGGACCT GGAGGCGGTG CTGGCCGACG 2281 TGAGCTACCT GATGGCCATG GAGAAGAGCA AGGCCACGCC GGCCGCGCGC GCCAGCAAGA 2341 AGATACTGCT GCCCGAGCCC AGGTGAGGAG AAGCT (2) INFORMATION FOR SEQ ID NO:2430: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 4382 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear WO 00/09525 PCT/US99/17712 EPI-109 579 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2430: GCCGCCGCCG CCAAGATGGC GGACCTGGAG GCGGTGCTGG CCGACGTGAG CTACCTGATG GCCATGGAGA AGAGCAAGGC CACGCCGGCC GCGCGCGCCA GCAAGAAGAT ACTGCTGCCC GAGCCCAGCA TCCGCAGTGT CATGCAGAAG TACCTGGAGG ACCGGGGCGA GGTGACCTTT GAGAAGATCT TTTCCCAGAA GCTGGGGTAC CTGCTCTTCC GAGACTTCTG CCTGAACCAC CTGGAGGAGG CCAGGCCCTT GGTGGAATTC TATGAGGAGA TCAAGAAGTA CGAGAAGCTG GAGACGGAGG AGGAGCGTGT GGCCCGCAGC CGGGAGATCT TCGACTCATA CATCATGAAG GAGCTGCTGG CCTGCTCGCA TCCCTTCTCG AAGAGTGCCA CTGAGCATGT CCAAGGCCAC CTGGGGAAGA AGCAGGTGCC TCCGGATCTC TTCCAGCCAT ACATCGAAGA GATTTGTCAA AACCTCCGAG GGGACGTGTT CCAGAAATTC ATTGAGAGCG ATAAGTTCAC ACGGTTTTGC CAGTGGAAGA ATGTGGAGCT CAACATCCAC CTGACCATGA ATGACTTCAG CGTGCATCGC ATCATTGGGC GCGGGGGCTT TGGCGAGGTC TATGGGTGCC GGAAGGCTGA CACAGGCAAG ATGTACGCCA TGAAGTGCCT GGACAAAAAG CGCATCAAGA TGAAGCAGGG GGAGACCCTG GCCCTGAACG AGCGCATCAT GCTCTCGCTC GTCAGCACTG GGGACTGCCC ATTCATTGTC TGCATGTCAT ACGCGTTCCA CACGCCAGAC AAGCTCAGCT TCATCCTGGA CCTCATGAAC GGTGGGGACC TGCACTACCA CCTCTCCCAG CACGGGGTCT TCTCAGAGGC TGACATGCGC TTCTATGCGG CCGAGATCAT CCTGGGCCTG GAGCACATGC ACAACCGCTT CGTGGTCTAC CGGGACCTGA AGCCAGCCAA CATCCTTCTG GACGAGCATG GCCACGTGCG GATCTCGGAC CTGGGCCTGG CCTGTGACTT CTCCAAGAAG AAGCCCCATG CCAGCGTGGG CACCCACGGG TACATGGCTC CGGAGGTCCT GCAGAAGGGC GTGGCCTACG ACAGCAGTGC CGACTGGTTC TCTCTGGGGT GCATGCTCTT CAAGTTGCTG CGGGGGCACA GCCCCTTCCG GCAGCACAAG ACCAAAGACA AGCATGAGAT CGACCGCATG ACGCTGACGA TGGCCGTGGA GCTGCCCGAC TCCTTCTCCC CTGAACTACG CTCCCTGCTG GAGGGGTTGC TGCAGAGGGA TGTCAACCGG AGATTGGGCT GCCTGGGCCG AGGGGCTCAG GAGGTGAAAG AGAGCCCCTT TTTCCGCTCC CTGGACTGGC AGATGGTCTT CTTGCAGAAG TACCCTCCCC CGCTGATCCC CCCACGAGGG GAGGTGAACG CGGCCGACGC CTTCGACATT GGCTCCTTCG ATGAGGAGGA CACAAAAGGA ATCAAGTTAC TGGACAGTGA TCAGGAGCTC TACCGCAACT TCCCCCTCAC CATCTCGGAG CGGTGGCAGC AGGAGGTGCC AGAGACTGTC TTCGACACCA TCAACGCTGA GACAGACCGG CTGGAGGCTC GCAAGAAAGC CAAGAACAAG CACCTGGGCC ATGAGGAAGA CTACGCCCTG GGCAAGGACT GCATCATGCA TGGCTACATG TCCAAGATGG GCAACCCCTT CCTGACCCAG TGGCAGCGGC GGTACTTCTA CCTGTTCCCC AACCGCCTCG AGTGGCGGGG CGAGGGCGAG GCCCCGCAGA GCCTGCTGAC CATGGAGGAG ATCCAGTCGG TGGAGGAGAC GCAGATCAAG GAGCGCAAGT GCCTGCTCCT CAAGATCCGC GGTGGGAAAC AGTTCATTTT GCAGTGCGAT AGCGACCCTG AGCTGGTGCA GTGGAAGAAG GAGCTGCGCG ACGCCTACCG CGAGGCCCAG CAGCTGGTGC AGCGGGTGCC CAAGATGAAG AACAAGCCGC GCTCGCCCGT GGTGGAGCTG AGCAAGGTGC CGCTGGTCCA GCGCGGCAGT GCCAACGGCC TCTGACCCGC CCACCCGCCT CCAGGAAGCT ACCTGGAGGA GGTGAGTCTT AGCGGATGAG TAGGAGTTGT CCACGGAGGA AGGTACACAG AAGGGCTTCC AGGCCCAGGA AACAGCAGAG GCACAGAAGT GAGAATGGGT GGGTGAGTTG GTGGGGAAAC TCCAGGTGCA GAGGATGGTA GCGAAACAAA CTGGAGCATT AAGGTCCAAG TCCTCCAAGA TCTTGACTTG CAGATTAAGG AGTTTGTTCA CCTAATCTGC TTTGGGCAGA GTGTGGTGAG TCCTAGAGAC CCCTCTAGGT CTCTCCTCTC AGTAGCCCCA GAAGGCCTGG AGAGCTGCTT CTGGGTGCCA AGCAGGCAGT GACTCCATCA GATCTAGATT TGGGAAAAGC ATCCCTGGTC AGGGCCTGCA TCAGGGCAGT GGCTGGCCAT GAGGACCCTG AGAAGTAGAC AGATTCACGG AGATTCTCAG GAGGCCAGAC AGGAGACTAT GGTGACAAAT TAGATTAGAG AAGGGGAGAG AATGAAGGAG CAGTTGGGGT AAAAGAAAAC TGAGGCTGAC ATGGGTATAT GGGTGGCGAG TGACTCACCA CCCACTGAGA GGAGAACCTC ACAAGCTCTG ACATGCTCTG GTTCCAGGTT CTGTTGGGGC TGATCCAAGA TGGTAGCCTA GAGGTGCACA GAGATGGGGG CCTTGCTTTG CAAAAGGATG CTGGCTGCTG GCCCACAGCA TGGTAATGAG ATTTGAGCTT TATGTGCCCA GGGCTGGGAG GAGGGTCCTG TCACTTTGAA AGCAAAGAGA GGCTCTAGAG AGGGGCATGT TGAGATAGGA ATGCTGCCTT GAGACACCTG GCTTTCCCCA CTCTGGGTGG CTCTCAGCAG GGTGGGTTTC CCCTGCCAGG CAGCACTGAA CCTCTGTGCG CTTCCGGCTG GGAGAGTTTT TACCGTAACT ACATGTGGAA CCATCCTGAA GGAACATCTG GATGGGATGG GGTACAGGGA AGGGAGCTGC CAAGAGTGCT GGCCAGGGAC CTGGGTCTAT GAGCTGGTTG GGGGGTGGGG TTGGGTGCAG GGTACTTGAT CCTGAGTGGG CCTTCTGCGG CCAGGATTGG TTCTAGAGTA GGAGGGGTGG GATCGGGGAT GGGGGAAGCC TGTAACTGCG CTGCAGTTGT CAGGTCCCAG GTTCTGGGTG ACCTACTAAG GATTCTGGGT CCAGTGTGGG TCCCAGGTTA GACGTCCTAG TCCTGAGTCC GTGTCCACAG TTCTGGGTGT TGAGTCTAGG ACAGTGATCT GGAGTTGACA GTCCAATCTA GGTCTGAGTC CTGACCCCAA GTCTAGAGTT CAGGGTCATG GTAGTAGCCT AGGGTCAGAA TCAAGGTTGG GGTCAGTAAC CAGGATGGGA TCGAGGTCAT GGTCCAAAAT CTGGATCTGG GGACCTGTTG GGGGTCTGAG GTGAGTGTCG CAGTCTGGGT ATGGCGTTGG AGACCCAGGG CTGTGATCTG AGGTCATGGT TAGAGTCTCA GGTGGTGGGC CAAGGTTTGA GTCTGGGGTC CTGTTTGGAG TCTGGTGTCA GGTCGTGGAC TGCGTCCAAG GTCAGGGAGT CCGGGGTTAT AGCCAGGGTC TGAGATGAAA GTCCCAGATG GTGTTCAGAG GTCTGAATCT GTGTCTTGGT GAGCGTCCAG GTTCCCTGTG ATCACGTTTG GTGTCAGGGC TGCGGCCCGA CTGGGGAGCC TGGGATCCAG AGATGTGACC CGAGGTTGTG GTCAGAGAAT GGGTCTCGGG TCGTCTTCGT GCCGGGTCCC TGTCGTGTTC CAGGCCCGGG TCTCCGTCCA GCATCGAGGG CCGAGGTCAC GGCCAGGGTC TGAGCCCGCG GTCGCAGGTC TGGTTCGGGG TCAGATTCCG CGCGGCCTCC AGGGGGCGCC GTCGCCGCCC GGCTCGGCCC CTCGCGGGCT CGCTGGCGTT GTGCGCGGCA GGCGGGGCCG GAGGCGGCGG CGGCTCCGGG GGCG6GGGCC GGGCGGCGGC GGCGGCGGCG CCCCGACTGC AGTCCCGGCG GGAGCGGAGC GCGAAGCGCG GGGCCGGGCC CGGAGCCGGC GCCATGGGGC GGCGCCGCCT GTGAGCGGCG GCGAGCGGAG CCGCGGGCGC CGAGCAGGGC CAGGCGGGAG CGTCGGCGCC CGAGGCCGAG CGAGCCGCGG CCGGGCCGGG CCGAGCGCCG AGCGAGCAGG AGCGGCGGCG GCGGCGGCGG CGGCGGGAGG AGGCAGCGCC GCCGCCAAGA TGGCGGACCT GGAGGCGGTG CTGGCCGACG TGAGCTACCT GATGGCCATG GAGAAGAGCA AGGCCACGCC GGCCGCGCGC GCCAGCAAGA AGATACTGCT GCCCGAGCCC AGGTGAGGAG AAGCT 4382 (2) INFORMATION FOR SEQ ID NO:2431: WO 00/09525 PCT/US99/17712 EPI-109 580 (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 2581 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2431: 1 CAGATTCACA AACTGCAGGA CTGGGCAGGG AGCAGACAGT GAGCAAACGC CAGCAGGGCT 61 GCTGTGAATT TGTGTAAGGA TTGAGGGACA GTTGCTTTTC AGCATGGGCC CAGGAATGCC 121 AAGGAGACAT CTATGCACGA CCTTGGGAAA TGAGTTGATG TCTCCGGTAA AACACCGGAG 181 ACTAATTCCT GCCCTGCCCA ATTTTGCAGG GAGCATGGCT GTGAGGATGG GGTGAACTCA 241 CGCACAGCCA AGGACTCCAA AATCACAACA GCATTACTGT TCTTATTTGC TGCCACACCT 301 GAGCCAGCCT GCTCCTTCCC AGGAGTGGAG GAGGCCTGGG GGGAGGGAGA GGAGTGACTG 361 AGCTTCCCTC CCGTGTGTTC TCCGTCCCTG CCCCAGCAAG ACAACTTAGA TCTCCAGGAG 421 AACTGCCATC CAGCTTTGGT GCAATGGCTG AGTGCACAAG TGAGTTGTTG CCCTGGGTTT 481 CTTTAATCTA TTCAGCTAGA ACTTTGAAGG ACAATTTCTT GCATTAATAA AGGTTAAGCC 541 CTGAGGGGTC CCTGATAACA ACCTGGAGAC CAGGATTTTA TGGCTCCCCT CACTGATGGA 601 CAAGGAGGTC TGTGCCAAAG AAGAATCCAA TAAGCACATA TTGAGCACTT GCTGTATATG 661 CAGTATTGAG CACTGTAGGC AAGACCCAAG AAAGAGAAGG AGCCATCTCC ATCTTGAAGG 721 AACTCAAAGA CTCAAGTGGG AACGACTGGG CACTGCCACC ACCAGAAAGC TGTTCGACGA 781 GACGGTCGAG CAGGGTGCTG TGGGTGATAT GGACAGCAGA AGGGGGAGAC CAAGGTTCCA 841 GCTCAACCAA TAACTATTGC ACAACCACCT GTCCCTGCCT CAGTTCCCTT TTATGTAACA 901 TGAAGTCGTT GTGAGGGTTA AAGGCAGTAA CAGGTATAAA GTACTTAGAA AAGCAAAGGG 961 TGCTACGTAC ATGTGAGGCA TCATTACGCA GACGTAACTG GGATATGTTT ACTATAAGGA 1021 AAAGACACTG AGGTCTAGAA ATAGCTCCGT GGAGCAGAAT CAGTATTGGG AGCCGGTGGC 1081 GGTGTGAAGC ACCAGTGTCT GGCACACAGT AGGTGCTCAT TGGCTCCCTT CCACCTGTCA 1141 TTCCCACCAC CCTGAGGCCC CAACCGCCAC ACACACAGGA GCATTTGGAG AGAAGGCCAT 1201 GTCTTCAAAG TCTGATTTGT GATGAGGCAG AGGAAGATAT TTCTAATCGG TCTTGCCCAG 1261 AGGATCACAG TGCTGAGACC CCCCACCACC AGCCGGTACC TGGGAAGGGG GAGAGTGCAG 1321 GCCTGCTCAG GGACTGTTCC TGTCTCAGCA ACCAAGGGAT TGTTCCTGTC AATCAATGGT 1381 TTATTGGAAG GTGGCCCAGT ATGAGCCCTA GAAGAGTGTG AAAAGGAATG GCAATGGTGT 1441 TCACCATCGG CAGTGCCAGG GCAGCACTCA TTCACTTGAT AAATGAATAT TTATTAGCTG 1501 GTTGGAGAGC TAGAACCTGG AGAGCTAGAA CCTGGAGAAC TAGAACCTGG AGGGCTAGAA 1561 CCTGGAGAGG CTAGAACCAA GAAGGGCTAG AACCTGGAGG GGCTAGAACC TAGAGAAGCT 1621 AAAACCTGAG CTAGAAGCTG GAGGACTAGA ACCTGGAGGG CTGGAATCTG AAGGGCTAGA 1681 ACCTGGAGGG CTGGAATCTG GAGAGCTAGA ACCTGGAGGG CTAGAACCTG GAGGGCTAGA 1741 ACCTAGAAGG GCTAGAACCT GGAGGGCTGG AATCTGGAGA GCTAGAACCT GGAGGGCTAG 1801 AACCTGGAGG GCTAGAACCT AGAAGGGCTA GAACCTGGAG GGCTAGAACC TGGCAGGTTA 1861 GAACCTAGAA GGGCTAGAAC CTGGAGAGCC AGAACCTGGA GGGCTAGAAC CTGGAAGGGC 1921 TAGAACCTGT AGAGCTAGAA CATGGAGAGC TAGAACCCGG CAGGCTAGAA CCTGGCAAGC 1981 TAGAACCTGG AGGGAATGAA CCTGGAGGGC TAGAACCTGG AGAATGAGAA AAATTTACAT 2041 GGCAAAGAGC CCATAAATCC TGACCAATCC AACTCTGAAT TTTAAAGCAA AAGCGTGAAA 2101 AAAAAGATTC CCTCCTTACC CCCAACCCAC TCTTTTTTCC CACCACCCAC TCTCCTCTGC 2161 CTCAGTAAGT ATCTGGAGGA AGAAAACAGG TGAAAGAAGA AGTAAAAACC ATTTAGTATT 2221 AGTATTAGAA TGAAGTCAAA CTGTGCCACA CATGGTGAAT GAAAAAAAAA AAAAAGAGGC 2281 TGTGTTTTGT CACACAGGGC AGTCATTCAG CACCAGAGCA CGTGATGGTC TGAGACTCTC 2341 TTAGGAGCAG AGCTCTGCCG CAATGGCCAT GTGGGGATCC ACACCTGGTC TGAGGGGCAA 2401 CTGAGTCTGC GGGAGAAGAG CGGCCCTATG CATGGTGTAG ATGCCCTGAT AAAGAACATC 2461 TGTCCTGTGA AAGACTCAAT GAGCTGTTAT GTTGTAAACA GGAAGCATTT CACATCCAAA 2521 CGAGAAAATC ATGTAAACAT GTGTCTTTTC TGTAGAGCAT AATAAATGGA TGAGGTTTTT 2581 GCAAAAAAAA AAAAAAAAA (2) INFORMATION FOR SEQ ID NO:2432: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 961 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2432: 1 ATGCCGCCCT CCATCTCAGC TTTCCAGGCC GCCTACATCG GCATCGAGGT GCTCATCGCC 61 CTGGTCTCTG TGCCCGGGAA CGTGCTGGTG ATCTGGGCGG TGAAGGTGAA CCAGGCGCTG 121 CGGGATGCCA CCTTCTGCTT CATCGTCTCG CTGGCGGTGG CTGATGTGGC CGTGGGTGCC 181 CTGGTCATCC CCCTCGCCAT CCTCATCAAC ATTGGGCCAC AGACCTACTT CCACACCTGC 241 CTCATGGTTG CCTGTCCGGT CCTCATCCTC ACCCAGAGCT CCATCCTGGC CCTGCTGGCA 301 ATTGCTGTGG ACCGCTACCT CCGGGTCAAG ATCCCTCTCC GGTACAAGAT GGTGGTGACC 361 CCCCGGAGGG CGGCGGTGGC CATAGCCGGC TGCTGGATCC TCTCCTTCGT GGTGGGACTG 421 ACCCCTATGT TTGGCTGGAA CAATCTGAGT GCGGTGGAGC GGGCCTGGGC AGCCAACGGC 481 AGCATGGGGG AGCCCGTGAT CAAGTGCGAG TTCGAGAAGG TCATCAGCAT GGAGTACATG 541 GTCTACTTCA ACTTCTTTGT GTGGGTGCTG CCCCCGCTTC TCCTCATGGT CCTCATCTAC WO 00/09525 PCT/US99/17712 EPI-109 581 601 CTGGAGGTCT TCTACCTAAT CCGCAAGCAG CTCAACAAGA AGGTGTCGGC CTCCTCCGGC 661 GACCCGCAGA AGTACTATGG GAAGGAGCTG AAGATCGCCA AGTCGCTGGC CCTCATCCTC 721 TTCCTCTTTG CCCTCAGCTG GCTGCCTTTG CACATCCTCA ACTGCATCAC CCTCTTCTGC 781 CCGTCCTGCC ACAAGCCCAG CATCCTTACC TACATTGCCA TCTTCCTCAC GCACGGCAAC 841 TCGGCCATGA ACCCCATTGT CTATGCCTTC CGCATCCAGA AGTTCCGCGT CACCTTCCTT 901 AAGATTTGGA ATGACCATTT CCGCTGCCAG CCTGCACCTC CCATTGACGA GGATCTCCCA 961 GAAGAGAGGC CTGATGACTA G (2) INFORMATION FOR SEQ ID NO:2433: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 2881 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2433: 1 ATGAGTGTCA GAAGTGTGAA GGGTGCCTGT TCTGAATCCC AGAGCCTCCT CTCCCTCTGT 61 GAGGCTGGCA GGTGAGGAAG GGTTTAACCT CACTGGAAGG AATCCCTGGA GCTAGCGGCT 121 GCTGAAGGCG TCGAGGTGTG GGGGCACTTG GACAGAACAG TCAGGCAGCC GGGAGCTCTG 181 CCAGCTTTGG TGACCTTGGG CCGGGCTGGG AGCGCTGCGG CGGGAGCCGG AGGACTATGA 241 GCTGCCGCGC GTTGTCCAGA GCCCAGCCCA GCCCTACGCG CGCGGCCCGG AGCTCTGTTC 301 CCTGGAACTT TGGGCACTGC CTCTGGGACC CCTGCCGGCC AGCAGGCAGG ATGGTGCTTG 361 CCTCGTGCCC CTTGGTGCCC GTCTGCTGAT GTGCCCAGCC TGTGCCCGCC ATGCCGCCCT 421 CCATCTCAGC TTTCCAGGCC GCCTACATCG GCATCGAGGT GCTCATCGCC CTGGTCTCTG 481 TGCCCGGGAA CGTGCTGGTG ATCTGGGCGG TGAAGGTGAA CCAGGCGCTG CGGGATGCCA 541 CCTTCTGCTT CATCGTGTCG CTGGCGGTGG CTGATGTGGC CGTGGGTGCC CTGGTCATCC 601 CCCTCGCCAT CCTCATCAAC ATTGGGCCAC AGACCTACTT CCACACCTGC CTCATGGTTG 661 CCTGTCCGGT CCTCATCCTC ACCCAGAGCT CCATCCTGGC CCTGCTGGCA ATTGCTGTGG 721 ACCGCTACCT CCGGGTCAAG ATCCCTCTCC GGTACAAGAT GGTGGTGACC CCCCGGAGGG 781 CGGCGGTGGC CATAGCCGGC TGCTGGATCC TCTCCTTCGT GGTGGGACTG ACCCCTATGT 841 TTGGCTGGAA CAATCTGAGT GCGGTGGAGC GGGCCTGGGC AGCCAACGGC AGCATGGGGG 901 AGCCCGTGAT CAAGTGCGAG TTCGAGAAGG TCATCAGCAT GGAGTACATG GTCTACTTCA 961 ACTTCTTTGT GTGGGTGCTG CCCCCGCTTC TCCTCATGGT CCTCATCTAC CTGGAGGTCT 1021 TCTACCTAAT CCGCAAGCAG CTCAACAAGA AGGTGTCGGC CTCCTCCGGC GACCCGCAGA 1081 AGTACTATGG GAAGGAGCTG AAGATCGCCA AGTCGCTGGC CCTCATCCTC TTCCTCTTTG 1141 CCCTCAGCTG GCTGCCTTTG CACATCCTCA ACTGCATCAC CCTCTTCTGC CCGTCCTGCC 1201 ACAAGCCCAG CATCCTTACC TACATTGCCA TCTTCCTCAC GCACGGCAAC TCGGCCATGA 1261 ACCCCATTGT CTATGCCTTC CGCATCCAGA AGTTCCGCGT CACCTTCCTT AAGATTTGGA 1321 ATGACCATTT CCGCTGCCAG CCTGCACCTC CCATTGACGA GGATCTCCCA GAAGAGAGGC 1381 CTGATGACTA GACCCCGCCT TCCGCTCCCA CCAGCCCACA TCCAGTGGGG TCTCAGTCCA 1441 GTCCTCACAT GCCCGCTGTC CCAGGGGTCT CCCTGAGCCT GCCCCAGCTG GGCTGTTGGC 1501 TGGGGGCATG GGGGAGGCTC TGAAGAGATA CCCACAGAGT GTGGTCCCTC CACTAGGAGT 1561 TAACTACCCT ACACCTCTGG GCCCTGCAGG AGGCCTGGGA GGGCAAGGGT CCTACGGAGG 1621 GACCAGGTGT CTAGAGGCAA CAGTGTTCTG AGCCCCCACC TGCCTGACCA TCCCATGAGC 1681 AGTCCAGCGC TTCAGGGCTG GGCAGGTCCT GGGGAGGCTG AGACTGCAGA GGAGCCACCT 1741 GGGCTGGGAG AAGGTGCTTG GGCTTCTGCG GTGAGGCAGG GGAGTCTGCT TGTCTTAGAT 1801 GTTGGTGGTG CAGCCCCAGG ACCAAGCTTA AGGAGAGGAG AGCATCTGCT CTGAGACGGA 1861 TGGAAGGAGA GAGGTTGAGG ATGCACTGGC CTGTTCTGTA GGAGAGACTG GCCAGAGGCA 1921 GCTAAGGGGC AGGAATCAAG GAGCCTCCGT TCCCACCTCT GAGGACTCTG GACCCCAGGC 1981 CATACCAGGT GCTAGGGTGC CTGCTCTCCT TGCCCTGGGC CAGCCCAGGA TTGTACGTGG 2041 GAGAGGCAGA AAGGGTAGGT TCAGTAATCA TTTCTGATGA TTTGCTGGAG TGCTGGCTCC 2101 ACGCCCTGGG GAGTGAGCTT GGTGCGGTAG GTGCTGGCCT CAAACAGCCA CGAGGTGGTA 2161 GCTCTGAGCC CTCCTTCTTG CCCTGAGCTT TCCGGGGAGG AGCCTGGAGT GTAATTACCT 2221 GTCATCTGGG CCACCAGCTC CACTGGCCCC CGTTGCCGGG CCTGGACTGT CCTAGGTGAC 2281 CCCATCTCTG CTGCTTCTGG GCCTGATGGA GAGGAGAACA CTAGACATGC CAACTCGGGA 2341 GCATTCTGCC TGCCTGGGAA CGGGGTGGAC GAGGGAGTGT CTGTAAGGAC TCAGTGTTGA 2401 CTGTAGGCGC CCCTGGGGTG GGTTTAGCAG GCTGCAGCAG GCAGAGGAGG AGTACCCCCC 2461 TGAGAGCATG TGGGGGAAGG CCTTGCTGTC ATGTGAATCC CTCAATACCC CTAGTATCTG 2521 GCTGGGTTTT CAGGGGCTTT GGAAGCTCTG TTGCAGGTGT CCGGGGGTCT AGGACTTTAG 2581 GGATCTGGGA TCTGGGGAAG GACCAACCCA TGCCCTGCCA AGCCTGGAGC CCCTGTGTTG 2641 GGGGGCAAGG TGGGGGAGCC TGGAGCCCCT GTGTGGGAGG GCGAGGCGGG GGAGCCTGGA 2701 GCCCCTGTGT GGGAGGGCGA GGCGGGGGAT CCTGGAGCCC CTGTGTCGGG GGGCGAGGGA 2761 GGGGAGGTGG CCGTCGGTTG ACCTTCTGAA CATGAGTGTC AACTCCAGGA CTTGCTTCCA 2821 AGCCCTTCCC TCTGTTGGAA ATTGGGTGTG CCCTGGCTCC CAAGGGAGGC CCATGTGACT 2881 AATAAAAAAC TGTGAACCCT A2) INFORMATION FOR SEQ ID NO:2434: Ci) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1921 base pairs WO 00/09525 PCTIUS99/17712 EPI-109 582 (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2434: 1 CGCATTTGTG TTTTAATAAA AGAATCTGGA AGATAAATAG TCTTGAAGAG AGACAAAGGA 61 AGGAAAATTT AAATCCTTAG ATTCAAGCAG AAGAATTCCA TGTGGAAGGT TTGGGTTGTT 121 GTTGTTGTTG TTTGGTGTGT TTTTTGTTTT TTTGTTTTTT TGTTTTTTTT TGAGATGGAG 181 TCTCGCTGTG TTACCGGGAG CGACAGAGCC GCACGGCCGA GTCGAGTCCC AGCCAGCTAC 241 CATCCCTCTG GAGCTTACCG GCCGGCCTTG GCTTCCCCAG GAATCCCTGG AGCTAGCGGC 301 TGCTGAAGGC GTCGAGGTGT GGGGGCACTT GGACAGAACA GTCAGGCAGC CGGGAGCTCT 361 GCCAGCTTTG GTGACCTTGG GTGCTTGCCT CGTGCCCCTT GGTGCCCGTC TGCTGATGTG 421 CCCAGCCTGT GCCCGCCATG CCGCCCTCCA TCTCAGCTTT CCAGGCCGCC TACATCGGCA 481 TCGAGGTGCT CATCGCCCTG GTCTCTGTGC CCGGGAACGT GCTGGTGATC TGGGCGGTGA 541 AGGTGAACCA GGCGCTGCGG GATGCCACCT TCTGCTTCAT CGTGTCGCTG GCGGTGGCTG 601 ATGTGGCCGT GGGTGCCCTG GTCATCCCCC TCGCCATCCT CATCAACATT GGGCCACAGA 661 CCTACTTCCA CACCTGCCTC ATGGTTGCCT GTCCGGTCCT CATCCTCACC CAGAGCTCCA 721 TCCTGGCCCT GCTGGCAATT GCTGTGGACC GCTACCTCCG GGTCAAGATC CCTCTCCGGT 781 ACAAGATGGT GGTGACCCCC CGGAGGGCGG CGGTGGCCAT AGCCGGCTGC TGGATCCTCT 841 CCTTCGTGGT GGGACTGACC CCTATGTTTG GCTGGAACAA TCTGAGTGCG GTGGAGCGGG 901 CCTGGGCAGC CAACGGCAGC ATGGGGGAGC CCGTGATCAA GTGCGAGTTC GAGAAGGTCA 961 TCAGCATGGA GTACATGGTC TACTTCAACT TCTTTGTGTG GGTGCTGCCC CCGCTTCTCC 1021 TCATGGTCCT CATCTACCTG GAGGTCTTCT ACCTAATCCG CAAGCAGCTC AACAAGAAGG 1081 TGTCGGCCTC CTCCGGCGAC CCGCAGAAGT ACTATGGGAA GGAGCTGAAG ATCGCCAAGT 1141 CGCTGGCCCT CATCCTCTTC CTCTTTGCCC TCAGCTGGCT GCCTTTGCAC ATCCTCAACT 1201 GCATCACCCT CTTCTGCCCG TCCTGCCACA AGCCCAGCAT CCTTACCTAC ATTGCCATCT 1261 TCCTCACGCA CGGCAACTCG GCCATGAACC CCATTGTCTA TGCCTTCCGC ATCCAGAAGT 1321 TCCGCGTCAC CTTCCTTAAG ATTTGGAATG ACCATTTCCG CTGCCAGCCT GCACCTCCCA 1381 TTGACGAGGA TCTCCCAGAA GAGAGGCCTG ATGACTAGAC CCCGCCTTCC GCTCCCACCG 1441 CCCACATCCA GTGGGGTCTC AGTCCAGTCC TCACATGCCC GCTGTCCCAG GGGTCTCCCT 1501 GAGCCTGCCC CAGCTGGGCT GTTGGCTGGG GGCATGGGGG AGGCTCTGAA GAGATACCCA 1561 CAGAGTGTGG TCCCTCCACT AGGAGTTAAC TACCCTACAC CTCTGGGCCC TGCAGGAGGC 1621 CTGGGAGGGC AAGGGTCCTA CGGAGGGACC AGGTGTCTAG AGGCAACAGT GTTCTGAGCC 1681 CCCACCTGCC TGACCATCCC ATGAGCAGTC CAGAGCTTCA GGGCTGGGCA GGTCCTGGGG 1741 AGGCTGAGAC TGCAGAGGAG CCACCTGGGC TGGGAGAAGG TGCTTGGGCT TCTGCGGTGA 1801 GGCAGGGGAG TCTGCTTGTC TTAGATGTTG GTGGTGCAGC CCCAGGACCA AGCTTAAGGA 1861 GAGGAGAGCA TCTGCTCTGA GACGGATGGA AGGAGAGAGG TTGAGGATGC ACTGGCCTGT 1921 TCTGTAGGAG AGACTGGCCA GA (2) INFORMATION FOR SEQ ID NO:2435: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1681 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2435: 1 CCCAGCCCCG AGGCTCAGAA GCGGCAGGCG GAGGCGCGCT CCGGGCGCTA TGGCCATGCC 61 CGGCGGGTCT CACGCGGCTG CCCCTCGCCC GGCGCGCCTT CGGTAGGGGG CGCCCGGGGC 121 CCAGCTGGCC CGGCCATGCT GCTGGAGACA CAGGACGC C TGTACGTGGC CCTGGAGCTG 181 GTCATCGCCG CGCTTTCGGT GGCGGGCAAC GTGCTGGTGT GCGCCGCGGT GGGCACGGCG 241 AACACTCTGC AGACGCCCAC CAACTACTTC CTGGTGTCCC TGGCTGCGGC CGACGTGGCC 301 GTGGGGCTCT TCGCCATCCC CTTTGCCATC ACCATCAGCC TGGGCTTCTG CACTGACTTC 361 TACGGCTGCC TCTTCCTCGC CTGCTTCGTG CTGGTGCTCA CGCAGAGCTC CATCTTCAGC 421 CTTCTGGCCG TGGCAGTCGA CAGATACCTG GCCATCTGTG TCCCGCTCAG GTATAAAAGT 481 TTGGTCACGG GGACCCGAGC AAGAGGGGTC ATTGCTGTCC TCTGGGTCCT TGCCTTTGGC 541 ATCGGATTGA CTCCATTCCT GGGGTGGAAC AGTAAAGACA GTGCCACCAA CAACTGCACA 601 GAACCCTGGG ATGGAACCAC GAATGAAAGC TGCTGCCTTG TGAAGTGTCT CTTTGAGAAT 661 GTGGTCCCCA TGAGCTACAT GGTATATTTC AATTTCTTTG GGTGTGTTCT GCCCCCACTG 721 CTTATAATGC TGGTGATCTA CATTAAGATC TTCCTGGTGG CCTGCAGGCA GCTTCAGCGC 781 ACTGAGCTGA TGGACCACTC GAGGACCACC CTCCAGCGGG AGATCCATGC AGCCAAGTCA 841 CTGGCCATGA TTGTGGGGAT TTTTGCCCTG TGCTGGTTAC CTGTGCATGC TGTTAACTGT 901 GTCACTCTTT TCCAGCCAGC TCAGGGTAAA AATAAGCCCA AGTGGGCAAT GAATATGGCC 961 ATTCTTCTGT CACATGCCAA TTCAGTTGTC AATCCCATTG TCTATGCTTA CCGGAACCGA 1021 GACTTCCGCT ACACTTTTCA CAAAATTATC TCCAGGTATC TTCTCTGCCA AGCAGATGTC 1081 AAGAGTGGGA ATGGTCAGGC TGGGGTACAG CCTGCTCTCG GTGTGGGCCT ATGATCTAGG 1141 CTCTCGCCTC TTCCAGGAGA AGATACAAAT CCACAAGAAA CAAAGAGGAC ACGGCTGGTT 1201 TTCATTGTGA AAGATAGCTA CACCTCACAA GGAAATGGAC TGCCTCTCTT GAGCACTTCC 1261 CTGGAGCTAC CACGTATCTA GCTAATATGT ATGTGTCAGT AGTAGCACCA AGGATTGACA 1321 AATATATTTA TGATCTATTC AGCTGCTTTT ACTGTGTGGA TTATGCCAAC AGCTTGAATG 1.381 GATTCTAACA GACTCTTTTC TTTTTAAAAG TCTGCCTTGT TTATGGTGGA AAATTACTGA WO 00/09525 PCT/US99/17712 EPI-109 583 1441 AACTATTTTA CTGTGAAACA GTGTGAACTA TTATAATGCA AATACTTTTT AACTTAGAGG 1501 CAATGGAAAA ATAAAAGTTG ACTGTACTAA AAATGTATAC TTGTTGCCAG GAAGGTGACC 1561 TCAAAAATTA AAAGTATAAT TATTCGGCCG GGCATGGTGG CTCACACCTG TAATTCCAGC 1621 ACTTTGGGAG GCCAAGGCAG GCGGATCACG AGGTCAGGAG TTCAAAACCA GCCTGTCCAA 1681 TATAGTG (2) INFORMATION FOR SEQ ID NO:2436: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1681 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2436: 1 GGGCAATTTG TTAGTTATCC GCCGCCACCA AGACGCGGCA CGGCGCCTGG ACCGGAGGGG 61 CCCCGCGCGG GCGCGAACTT TGGGCTCGGG CGAGTGGGTG GTGCTCCGCC CAGCCCGAGA 121 CGGGCGGGCG CGCGGGCCAA TGGGTGCCGC CTCTTGGCCG CGGGGGGCCC CGACCCGTGG 181 GTCCCGGCCA CCAGCGCCCC AGCCCCGAGG CTCAGAAGCG GCAGGCGGAG GCGCGGTCCG 241 GGCGCTATGG CCATGCCCGG CGGGTCTCAC GCGGCTGCCC CTCGCCCGGC GCGCCTTCGG 301 TAGGGGGCGC CCGGGGCCCA GCTGGCCCGG CCATGCTGCT GGAGACACAG GACGCGCTGT 361 ACGTGGCGCT GGAGCTGGTC ATCGCCGCGC TTTCGGTGGC GGGCAACGTG CTGGTGTGCG 421 CCGCGGTGGG CACGGCGAAC ACTCTGCAGA CGCCCACCAA CTACTTCCTG GTGTCCCTGG 481 CTGCGGCCGA CGTGGCCGTG GGGCTCTTCG CCATCCCCTT TGCCATCACC ATCAGCCTGG 541 GCTTCTGCAC TGACTTCTAC GGCTGCCTCT TCCTCGCCTG CTTCGTGCTG GTGCTCACGC 601 AGAGCTCCAT CTTCAGCCTT CTGGCCGTGG CAGTCGACAG ATACCTGGCC ATCTGTGTCC 661 CGCTCAGGTA TAAAAGTTTG GTCACGGGGA CCCGAGCAAG AGGGGTCATT GCTGTCCTCT 721 GGGTCCTTGC CTTTGGCATC GGATTGACTC CATTCCTGGG GTGGAACAGT AAAGACAGTG 781 CCACCAACAA CTGCACAGAA CCCTGGGATG GAACCACGAA TGAAAGCTGC TGCCTTGTGA 841 AGTGTCTCTT TGAGAATGTG GTCCCCATGA GCTACATGGT ATATTTCAAT TTCTTTGGGT 901 GTGTTCTGCC CCCACTGCTT ATAATGCTGG TGATCTACAT TAAGATCTTC CTGGTGGCCT 961 GCAGGCAGCT TCAGCGCACT GAGCTGATGG ACCACTCGAG GACCACCCTC CAGCGGGAGA 1021 TCCATGCAGC CAAGTCACTG GCCATGATTG TGGGGATTTT TGCCCTGTGC TGGTTACCTG 1081 TGCATGCTGT TAACTGTGTC ACTCTTTTCC AGCCAGCTCA GGGTAAAAAT AAGCCCAAGT 1141 GGGCAATGAA TATGGCCATT CTTCTGTCAC ATGCCAATTC AGTTGTCAAT CCCATTGTCT 1201 ATGCTTACCG GAACCGAGAC TTCCGCTACA CTTTTCACAA AATTATCTCC AGGTATCTTC 1261 TCTGCCAAGC AGATGTCAAG AGTGGGAATG GTCAGGCTGG GGTACAGCCT GCTCTCGGTG 1321 TGGGCCTATG ATCTAGGCTC TCGCCTCTTC CAGGAGAAGA TACAAATCCA CAAGAAACAA 1381 AGAGGACACG GCTGGTTTTC ATTGTGAAAG ATAGCTACAC CTCACAAGGA AATGGACTGC 1441 CTCTCTTGAG CACTTCCCTG GAGCTACCAC GTATCTAGCT AATATGTATG TGTCAGTAGT 1501 AGGCTCCAAG GATTGACAAA TATATTTATG ATCTATTCAG CTGCTTTTAC TGTGTGGATT 1561 ATGCCAACAG CTTGAATGGA TTCTAACAGA CTCTTTTGTT TTTAAAAGTC TGCCTTGTTT 1621 ATGGTGGAAA ATTACTGAAA CTATTTTACT GTGAAACAGT GTGAACTATT ATAATGCAAA 1681 TACTTTTTAA CTTAGAGGCA ATGGAAAAAT AAAAGTTGAC TGTACTAAAA ATG (2) INFORMATION FOR SEQ ID NO:2437: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 2461 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2437: 1 GAATTCCCAG ATGGGCAGAG GTGGCTGGGC TGGTGACCCT AAGTGTGTCT CCTGCCTTTA 61 TTCTCTCTAG TGGGTTATTC TTTCATGTGG TATCTTGCCT ACAGCATGCT GTGTTTGGAC 121 ACAAACCCCT TTCCTTGGTT TCTCTGACCC AGCTGAGATG GACTGATTCC AAAAGAACTC 181 ACCTATGTAC TGGGGTAGGG GAGGGAGGGT TTTTTGCAGT ATTTAACTAA GGTTCAAAGA 241 GTGCTATATA GTGAGAAAGG CTTCTTTTTT TTTTTTTTTT TTTTTTGGCA GAGTGCTGCC 301 TCCTAGAAAT TTCTCTTGGT AACTTCCTTC TCTGAAGCAC AGATAAAGAA AACAATTACA 361 GTAGAAACAT TTATGAGGGA CACATTGGAG GCCGATGAAG CTTTTCAAGT TCCAGCAGTG 421 CAGGGATGTG GGCAGAACTG ACATTGGAAA ATACTAGAAT GATGGAAATT CAGTTGGAGA 481 GGACTGCCCT TTTTAATGTC TGGGGAGTCT GCTCAGGGAG AAATGACAAG TCTGGCGGGG 541 ACAAGTATGG GATTTGGTAA GACTTGGATC AACTTGGGAT ACAGGGTGGG GGTCGGGAGT 601 GGAATCAATG AATGATGCCA GAGCAGATCA ACTAACAAGA GGACCCTGAT GAGCCCCAGG 661 CAGAGGCGTC TCCCTTATGC CCCACTCTGA AGTGTTTGTT AGTAAACACC AGAACGCCAT 721 TGTTGTTACT GCTGAATTTT ATTTTGGGCT GTACATATTT AGATGCTTAA GGTAAAAATG 781 ATAAAGCCCT CAAGCCACTG TGTGGGTTTG GGTCCAAGTG TTCCTTCTTG CTGCCTCTCT 841 AACACGCCTG GTTAAAATAA TCCCTTTGGA TGGTGCTGAG AAGCACCTGA ACCAAGTGGG 901 TCCCCAAATA ACAATGGCGT GCAAGTGTCT GGTTCCCAGA AGTTGGTGAC TAGGTAAGCA 961 GCTTCAGGGA GAGGGGGCTG ATTCCCAGAC AGTCGCCTGT TCCTGCGGGG ATGGGGCTGA 1021 GGCTTGGGGA ATGTGGGCAG GAGGATATGC CATTTGATTC TGTTGCACAC GTTCTTTTCC 1081 CTTCTTTCTG TATGTCTGGT CATTCTGCTA TTCTGTCGTT CCTCACATAG GTTGGACATT WO 00/09525 PCT/US99/17712 EPI-109 584 1141 GGCCGGCTGC CAGCATAAGT GCCAGTGTGA TTTTGCTAGG TGTGAGCTGA GAAAGAGAGG 1201 TGGAGGCTAA GCAGGTGTGA TGCTTCTCAG AGGTGCTGAG TTTTTGCCCT TCTGAGCAGG 1261 GAATCTTTGC TTATCCCTTT GACCAAGGAT CTTTGCTGCA AAGGCTGGGT ATCGGCTGTG 1321 CTCAGCAAAG CGTCAACTCG TGCAAGAACT TAGCAGGAAT AGTTCTGGCT AAGGTTAGGA 1381 GGCTGCCACC AAAGTCTCTT TTTTGTTCCT CTGCTTCTCC CGTTTGCCTC CTTATCATGA 1441 GATCTTTTTG CTAAGCTGGC AGAAAGATTG CATAGTCAGT GCTTCCAGCT CTGCTCCCAC 1501 CTGATCCTGC ACTGTCCTCT GGTCCCTGAA TGAATGAACT CTGATACCCA ATCTTGTCTC 1561 GAGCCTTCTC TATGCCACTC ATGGCTCCTC TTCTGCTCTT TCCATCTTTT TGCTGAGAGT 1621 TCTGAGCTCT GTACTTCCTC TTGGCCCATC TCACTTCCTG AAACACCCCT GAAGAGGGTT 1681 GCTTATCTTG ATGGAACTCA AAAAGCCAAA AAGCTGCAGG CAGAGGCGTT GAGGACATCT 1741 GTTTGGGGAA CTAAGAGCAG CAGCACTTTC AGATTCAGTC CATATAGAGC TGTCCTACAG 1801 CATTCTGGAA ACTTGAGGAT GTGCGGTGCA TAAAGGGGCT GGAAGTGACC CACCTGTGAT 1861 GAGCCCTTTC TAAGGAGAAG GGTTTCCAAG AGATCACCCC ACCAGAAAAG GGTAGGAATG 1921 AGCAAGTTGG GAATTTTAGA CTGTCACTGC ACATGGACCT CTGGGAAGAC GTCTGGCGAG 1981 AGCTAGGCCC ACTGGCCCTA CAGACGGATC TTGCTGGCTC ACCTGTCCCT GTGGAGGTTC 2041 CCCTGGGAAG GCAAGATGCC CAACAACAGC ACTGCTCTGT CATTGGCCAA TGTTACCTAC 2101 ATCACCATGG AAATTTTCAT TGGACTCTGC GCCATAGTGG GCAACGTGCT GGTCATCTGC 2161 GTGGTCAAGC TGAACCCCAG CCTGCAGACC ACCACCTTCT ATTTCATTGT CTCTCTAGCC 2221 CTGGCTGACA TTGCTGTTGG GGTGCTGGTC ATGCCTTTGG CCATTGTTGT CAGCCTGGGC 2281 ATCACAATCC ACTTCTACAG CTGCCTTTTT ATGACTTGCC TACTGCTTAT CTTTACCCAC 2341 GCCTCCATCA TGTCCTTGCT GGCCATCGCT GTGGACCGAT ACTTGCGGGT CAAGCTTACC 2401 GTCAGGTAGC CTGCGGCGTG GGGTGGGCAG CAATTGAGGC AGCTGGGAAA TGAGGCTACA 2461 AAGCCAGAGC (2) INFORMATION FOR SEQ ID NO:2438: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1321 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2438: 1 CTGCTGAATT TTATTTTGGA CTGTACATAT TTAGATGCTT AAGGTAAAAA TGATAAAGCC 61 CTCAAGCCAC TGTGTGGGTT GGGTCCAAGT GTTCCTTGCT GCTGCCTCTC TAACACGCCT 121 GGTTAAAATA ATCCCTTTGG ATGGTGCTGA GAAGCACCTG AACCAAGTGG GTCCCCAAAT 181 AACTATGGCG TGCAAGTGTC TGGTTCCCAG AAGTTGGTGA CTAGGTAAGC GACTCAGGGA 241 GAGGGGCTGA TTCCCAGACA GTCGCCTGTT CCTGCTGGGA TGGGGCTGAG GCTTGGGGAA 301 TGTGGGCAGG AGGATATGCC ATTTGATTCT GTTGCACACG TTCTTTTCCC TTCTTTCTGT 361 ATGTCTGGTC ATTCTGCTAT TCTGTCGTTC CTCACATAGG TTGGACATTG GCCGGCTGCC 421 AGCATAAGTG CCAGTGTGAT TTTGCTAGGG TGTGAGCTGA GAAAGAGAGG TGGAGGCTAA 481 GCAGGTGTGA TGCTTCTCAG AGGTGCTGAG TTTTTGCCCT TCTGAGCAGG GAATCTTTGC 541 TTATCCCTTT GACCAAGGAT CTTTGCTCCA AAGGCTGGGT ATCGGCTGTG CTCAGCAAAG 601 CGTCAACTCG TGCAAGAACT TAGCAGGAAT AGTTCTGGCT AAGGTTAGGA GGCTGCCACC 661 AAAGTCTCTT TTTTGTTCCT CTGCTTCTCC CGTTTGCCTC CTTATCATGA GATCTTTTTG 721 CTAAGCTGGC AGAAAGATTG CATAATCAGT GCTTCCAGCT CCGCTCCCAC CTGATCCTGC 781 ACTGTCCTCT GGTCCCTGAA TGAATGAACT CTGATACCCA ATCTTGTCTC GAGCCTTCTC 841 TATGCCACTC ATGGCTCCTC TTCTGCTCTT TCCATCTTTT TGCTGAGAGT TACTGAGCTC 901 TGTACTTCCT CTTGGCCCAT CTCACTTCCT GAAACACCCC TGAAGAGGGT TGCTTATCTT 961 GATGGAACTC AAAAAGCCAA AAAGCTGCAG GCAGAGGCGT TGAGGACATC TGTTTGGGGA 1021 ACTAAGAGCA GCAGCACTTT CAGATTCAGT CCATATAGAG CTGTCCTACA GCATTCTGGA 1081 AACTTGAGGA TGTGCGGTGC ATAAAGGGGC TGGAAGTGAC CCACCTGTGA TGAGCCCTTT 1141 CTAAGGAGAA GGGTTTCCAA GAGATCACCC CACCAGAAAA GGGTAGGAAT GAGCAAGTTG 1201 GGAATTTTAG ACTGTCACTG CACATGGACC TCTGGGAAGA CGTCTGGCGA GAGCTAGGCC 1261 CACTGGCCCT ACAGACGGAT CTTGCTGGCT CACCTGTCCC TGTGGAGGTT CCCCTGGGAA 1321 GGCAAGATGC CCAACAACAG CACTGCTCTG (2) INFORMATION FOR SEQ ID NO:2439: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1741 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2439: 1 CGAATTCGGG GGACATCTGT TTGGGGAACT AAGAGCAGCA GCACTTTCAG ATTCAGTCCA 61 TATAGAGCTG TCCTACAGCA TTCTGGAAAC TTGAGGATGT GCGGTGCATA AACGGGCTGG 121 AAGTGACCCA CCTGTGATGA GCCCTTTCTA AGGAGAAGGG TTTCCAAGAG ATCACCCCAC 181 CAGAAAAGGG TAGGAATGAG CAAGTTGGGA ATTTTAGACT GTCACTGCAC ATGGACCTCT 241 GGGAAGACGT CTGGCGAGAG CTAGGCCCAC TGGCCCTACA GACGGATCTT GCTGGCTCAC 301 CTGTCCCTGT GGAGGTTCCC CTGGGAAGGC AAGATGCCCA ACAACAGCAC TGCTCTGTCA 361 TTGGCCAATG TTACCTACAT CACCATGGAA ATTTTCATTG GACTCTGCGC CATAGTGGGC WO 00/09525 PCT/US99/17712 EPI-109 585 421 AACGTGCTGG TCATCTGCGT GGTCAAGCTG AACCCCAGCC TGCAGACCAC CACCTTCTAT 481 TTCATTGTCT CTCTAGCCCT GGCTGACATT GCTGTTGGGG TGCTGGTCAT GCCTTTGGCC 541 ATTGTTGTCA GCCTGGGCAT CACAATCCAC TTCTACAGCT GCCTTTTTAT GACTTGCCTA 601 CTGCTTATCT TTACCCACGC CTCCATCATG TCCTTGCTGG CCATCGCTGT GGACCGATAC 661 TTGCGGGTCA AGCTTACCGT CAGATACAAG AGGGTCACCA CTCACAGAAG AATATGGCTG 721 GCCCTGGGCC TTTGCTGGCT GGTGTCATTC CTGGTGGGAT TGACCCCCAT GTTTGGCTGG 781 AACATGAAAC TGACCTCAGA GTACCACAGA AATGTCACCT TCCTTTCATG CCAATTTGTT 841 TCCGTCATGA GGATGGACTA CATGGTATAC TTCAGCTTCC TCACCTGGAT TTTCATCCCC 901 CTGGTTGTCA TGTGCGCCAT CTATCTTGAC ATCTTTTACA TCATTCGGAA CAAACTCAGT 961 CTGAACTTAT CTAACTCCAA AGAGACAGGT GCATTTTATG GACGGGAGTT CAAGACGGCT 1021 AAGTCCTTGT TTCTGGTTCT TTTCTTGTTT GCTCTGTCAT GGCTGCCTTT ATCTCTCATC 1081 AACTGCATCA TCTACTTTAA TGGTGAGGTA CCACAGCTTG TGCTGTACAT GGGCATCCTG 1141 CTGTCCCATG CCAACTCCAT GATGAACCCT ATCGTCTATG CCTATAAAAT AAAGAAGTTC 1201 AAGGAAACCT ACCTTTTGAT CCTCAAAGCC TGTGTGGTCT GCCATCCCTC TGATTCTTTG 1261 GACACAAGCA TTGAGAAGAA TTCTGAGTAG TTATCCATCA GAGATGACTC TGTCTCATTG 1321 ACCTTCAGAT TCCCCATCAA CAAACACTTG AGGGCCTGTA TGCCTGGGCC AAGGGATTTT 1381 TACATCCTTG ATTACTTCCA CTGAGGTGGG AGCATCTCCA GTGCTCCCCA ATTATATCTC 1441 CCCCACTCCA CTACTCTCTT CCTCCACTTC ATTTTTCCTT TGTCCTTTCT CTCTAATTCA 1501 GTGTTTTGGA GGCCTGACTT GGGGACAACG TATTATTGAT ATTATTGTCT GTTTTCCTTC 1561 TTCCCAATAG AAGAATAAGT CATGGAGCCT GAAGGGTGCC TAGTTGACTT ACTGACAAAA 1621 GGCTCTAGTT GGGCTGAACA TGTGTGTGGT GGTGACTCAT TTCCATGCCA TTGTGGAATT 1681 GAGCAGAGAA CCTGCTCTCG GAGGATGCCT AGGAGATGTT GGGAACAGAA GAAATAAACT 1741 GAGTTTAAGG GGGACTTAAA CTGCTGAATT C (2) INFORMATION FOR SEQ ID NO:2440: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 2041 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2440: 1 GCCGCCGCCG CCAAGATGGC GGACCTGGAG GCGGTGCTGG CCGACGTGAG CTACCTGATG 61 GCCATGGAGA AGAGCAAGGC CACGCCGGCC GCGCGCGCCA GCAAGAAGAT ACTGCTGCCC 121 GAGCCCAGCA TCCGCAGTGT CATGCAGAAG TACCTGGAGG ACCGGGGCGA GGTGACCTTT 181 GAGAAGATCT TTTCCCAGAA GCTGGGGTAC CTGCTCTTCC GAGACTTCTG CCTGAACCAC 241 CTGGAGGAGG CCAGGCCCTT GGTGGAATTC TATGAGGAGA TCAAGAAGTA CGAGAAGCTG 301 GAGACGGAGG AGGAGCGTGT GGCCCGCAGC CGGGAGATCT TCGACTCATA CATCATGAAG 361 GAGCTGCTGG CCTGCTCGCA TCCCTTCTCG AAGAGTGCCA CTGAGCATGT CCAAGGCCAC 421 CTGGGGAAGA AGCAGGTGCC TCCGGATCTC TTCCAGCCAT ACATCGAAGA GATTTGTCAA 481 AACCTCCGAG GGGACGTGTT CCAGAAATTC ATTGAGAGCG ATAAGTTCAC ACGGTTTTGC 541 CAGTGGAAGA ATGTGGAGCT CAACATCCAC CTGACCATGA ATGACTTCAG CGTGCATCGC 601 ATCATTGGGC GCGGGGGCTT TGGCGAGGTC TATGGGTGCC GGAAGGCTGA CACAGGCAAG 661 ATGTACGCCA TGAAGTGCCT GGACAAAAAG CGCATCAAGA TGAAGCAGGG GGAGACCCTG 721 GCCCTGAACG AGCGCATCAT GCTCTCGCTC GTCAGCACTG GGGACTGCCC ATTCATTGTC 781 TGCATGTCAT ACGCGTTCCA CACGCCAGAC AAGCTCAGCT TCATCCTGGA CCTCATGAAC 841 GGTGGGGACC TGCACTACCA CCTCTCCCAG CACGGGGTCT TCTCAGAGGC TGACATGCGC 901 TTCTATGCGG CCGAGATCAT CCTGGGCCTG GAGCACATGC ACAACCGCTT CGTGGTCTAC 961 CGGGACCTGA AGCCAGCCAA CATCCTTCTG GACGAGCATG GCCACGTGCG GATCTCGGAC 1021 CTGGGCCTGG CCTGTGACTT CTCCAAGAAG AAGCCCCATG CCAGCGTGGG CACCCACGGG 1081 TACATGGCTC CGGAGGTCCT GCAGAAGGGC GTGGCCTACG ACAGCAGTGC CGACTGGTTC 1141 TCTCTGGGGT GCATGCTCTT CAAGTTGCTG CGGGGGCACA GCCCCTTCCG GCAGCACAAG 1201 ACCAAAGACA AGCATGAGAT CGACCGCATG ACGCTGACGA TGGCCGTGGA GCTGCCCGAC 1261 TCCTTCTCCC CTGAACTACG CTCCCTGCTG GAGGGGTTGC TGCAGAGGGA TGTCAACCGG 1321 AGATTGGGCT GCCTGGGCCG AGGGGCTCAG GAGGTGAAAG AGAGCCCCTT TTTCCGCTCC 1381 CTGGACTGGC AGATGGTCTT CTTGCAGAAG TACCCTCCCC CGCTGATCCC CCCACGAGGG 1441 GAGGTGAACG CGGCCGACGC CTTCGACATT GGCTCCTTCG ATGAGGAGGA CACAAAAGGA 1501 ATCAAGTTAC TGGACAGTGA TCAGGAGCTC TACCGCAACT TCCCCCTCAC CATCTCGGAG 1561 CGGTGGCAGC AGGAGGTGGC AGAGACTGTC TTCGACACCA TCAACGCTGA GACAGACCGG 1621 CTGGAGGCTC GCAAGAAAGC CAAGAACAAG CAGCTGGGCC ATGAGGAAGA CTACGCCCTG 1681 GGCAAGGACT GCATCATGCA TGGCTACATG TCCAAGATGG GCAACCCCTT CCTGACCCAG 1741 TGGCAGCGGC GGTACTTCTA CCTGTTCCCC AACCGCCTCG AGTGGCGGGG CGAGGGCGAG 1801 GCCCCGCAGA GCCTGCTGAC CATGGAGGAG ATCCAGTCGG TGGAGGAGAC GCAGATCAAG 1861 GAGCGCAAGT GCCTGCTCCT CAAGATCCGC GGTGGGAAAC AGTTCATTTT GCAGTGCGAT 1921 AGCGACCCTG AGCTGGTGCA GTGGAAGAAG GAGCTGCGCG ACGCCTACCG CGAGGCCCAG 1981 CAGCTGGTGC AGCGGGTGCC CAAGATGAAG AACAAGCCGC GCTCGCCCGT GGTGGAGCTG 2041 AGCAAGGTGC CGCTGGTCCA GCGCGGCAGT GCCAACGGCC TCTGACCCGC CCACCCGCCT (2) INFORMATION FOR SEQ ID NO:2441: (i) SEQUENCE CHARACTERISTICS: WO 00/09525 PCT/US99/17712 EPI-109 586 (A) LENGTH: 7321 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2441: 1 AAATGATAGA CCGTCAATAA TTTGTTAAAT GCTTTTTAAA ATGAATGCTT TAAGCCGGGT 61 GCAGTGCCTC ACATCTGTAA TCCCAGCACT TTGGAGCCGA GCGGGTGGAT TGTGTGAGGT 121 CAGGAGTTCG AGACCAACCT GGCCAACATG GCAAAACCTC ACTCTCTACC AAAAATACAA 181 AAATTAGCCA GGCATGGTGG CAGGCACCTG TGATCCCAGC TACTCAGGAG GCTGAGACAG 241 GAGAATCGCT TGAACCCGGG AGGCAAGGTT GCAGTGAGCC AAGATTACGC CATTGTACTC 301 CAGCCTGGGT GACAGAGAGA GACTCCGTCT CAAAAAAAAA AAAAAAAAAA AAAAAATTAC 361 GCTTCAAACA CATGATCTCT CACCACTGTT GAATTTTCTT TCTATGAGCC CAGGAGGGCC 421 TCTCAGAGAG GAAAGCTCCT AGGTCTTCCT TTCCCTCTGC AAACTCCCTG CCTTGAAGGT 481 TCAGAAGGAC TGTGCGTGCT CGTTGCATCC TTTGCAAGTG TCCAAACCCT GATCCCAGCT 541 GTGCTTAGGG GTTCCTGCAA ACCTTTTCCA GGTGTTAATT ACCTCCCACT TCATTTCCTG 601 TTTACCAACT CAGCTTTTTG TTTTAGTGTG TTTGAATTCC CTGAACTGAC CGTTGTCTGA 661 TCTCCACCTC CCAACTGAAT TAGGGGAGCT GGGCTTCTGG AAACCCAGGT GCCGGGTGTT 721 GCAGAGTGGC TGAAAGCTGG GATGTGGCAG ATCCGTGGCT ACATTCATGC ACACACACAC 781 ACCCACATAC CCACACATGC ACACACACAC ACACACCCGC ACTCACACAC TTGGACATGC 841 ATAGACCACA GCTTTCCACA CCCTTCCTAG ACAGGGGTCA CTTGGTATCC TGGAGAGAGT 901 GTGAAGTCCT GGAATGGAAA GAGGGGGGAT TAAGCCCCAC CTCTAGCCAT GGGACTGAGA 961 CAAGTCACCA CCAACCCATC TGCGCCTTGT TTACCTCCTC TGTGAGGCAA GCACAGAGCC 1021 CATGCCTGCC CCCCTGGATG GGAGTGATGT GAAACTTGAA GGGCGGTCAG AGCAAGGGTC 1081 GGGAATGGAA GGCCCTTGGG AAAAAAGGCC CTTTCAACTA GGGGCACAGA GGAGGCCCTG 1141 GGCTGAGAAC TTGACAGCAC CTTGTAATTG GTAAGCCAAG CCCGAAGGGA CTGGAAATAC 1201 TCAGATGTGT CTGTCTCCCT TATTAGGTTC AAAGTCCCTC AAGACCCTGT CTCCATCACA 1261 GTGCTCCAGT CCAGACCCCT CCTCTGAGCT CCAGACCCTG CTGGACCCAA CCAGCCCTAT 1321 GGGGTCGCAT CCCCACCTGC CTGGAATTCT CCAAAGAACC TCCCCTTTAA CAGTTCCAGC 1381 CTTTAACAGT TCCAGTCTAA ACACATGACC TTTCTCCTCT AAATCAGCCC CCCATCTCTG 1441 CCTTTGCAGG AGATGGAAGC CATGACACCT GCCTCGCCCC TGTCCTCACC CCATCCATGT 1501 CCAATCAAGC ACTAGGCATG TCAGGTTTAC CCTCTAAACT CCTCTGGAAT CCAGTCTCTC 1561 AGTCTCCATC ATCCCAGGTC GAAGCTAATG GGCTAACTGG TCCTTGCTTC CACTCTACCC 1621 CCACTGCAGT CCTGACTTCC TGAGCAGCAG CCAGGGCCTA ATCGATATTC ACACCAAGCG 1681 CCAACCTGAC TGAGATATCC TCCTGCACCA TCATCCCTCC ACCCTGTTTA GTTCTGCTCA 1741 CCCTCAGTGT TCTCATCAAT AATCCACTCC CCTCACAGGC GCGTTTGGGA CCCCATGTTC 1801 TATGCTCTCA CAGGACCTTT TGCTTGATTT TTCACTGTAC TTAGGTCAGT TTGCAGTTAT 1861 TAAGTGACTG AGCAATGTCT GGCTTCTCCA GTAGACTGTC AGCTCCTAGC CATTGTATAC 1921 CTAGCACCGC TGTGTGGGAG CACGTGACAA ACGTCCAGTG AGTCAGGGAC TCAGCAGTCT 1981 CCATTTCTCC GCCCTGCTGG AGAATGCGTG TATTTGGCAA TCCCCAGCCC CTGTGCCATC 2041 TAACCATCTT TTCTTCTCTG TTCAGCCCAG GTGTGGCCTC ACTCACATCC CACTCTGAGT 2101 CCAAATGTTC TCTCCCTGGA AGATATCAAT GTTTCTGTCT GTTCGTGAGG ACTCCGTGCC 2161 CACCACGGCC TCTTTCAGGT GAGTCAAAGG GATTCCTCAG TTCACTAGTT AGGGGAGGTG 2221 GGCAGACACC CTGGAGAACT CCCTGGAAAG CTCAACTCTC ATGCCCCGGA CAACAGTTGA 2281 AGGAACCATG GTGATGTTAA GCCCAAAGAC AAAACCTCTC AGGTGTCCAA GTCCCTGTTG 2341 GAATCTTGGG AGCAGAGGGA ATGTTCTGTG GTCTAGAGGA AGAGGGGCTC AGGGAGGAGA 2401 AGGGCACATT CCTGGTTGTT ATATGTTTCT ATCTATCCCA GATGAACTTG GAAGTGAAGG 2461 GAAGAGAGTT AAACATTAAA GTAAATACCC AGTGGATCAG ACAGCAATGT GCCAGATTGC 2521 CTTGGAAACA AAATATCTCC AACACATGGC TGACATTTGG TGGGAGATCA GAACACCCTA 2581 AAGAGAGAAT TTAAGGGGAG GGGGAGGAGG ACCTGAGCCA GAGTAGAAGC AGAGGATAGG 2641 GAGATCTGTT CTTGGGGACA GCATTTGCAA GAAACAAGGC TGAGGGGTCC ACTCCAACCT 2701 CTCCACCCTG CTGCAGGTGC TGCCTATGAT GAAGATGAGC AGATGGCCAT CTCAGCTGGG 2761 GCCACAGTGC ACTGGACCTA TAGTTTCCAA TTCCGCACTC AGCAGGCATC TTTCTGATGA 2821 TCCGATGGCT TCTCAGAGCC AGGGATGGGC CAGGATCCAT CCCCTTGGCT ACTGTCTTGC 2881 TGAGAAATTT ATAAGCAGCA TCTGGTGCTA TACTTTGGTC TCTAGTGAGT TAGCTCATGA 2941 AAGATGATAG ACTCTCCAAG CCAGGGGTAT GCAGGAAATG GGTTTTCTGT AGCTACAGAA 3001 ATGGGGTTGA GGGTTGGACC AAGGGACTAC CCAGGGGAAG TCTTACCTTC AGAGGACTCT 3061 GGAAAGGAGG CTGCAAGTTT TCATGGGTCA AGAATTCAGA GCCCAGTAGA GACAGCTTAT 3121 CTCTGTTCCA AGATGTCTGG GGCCTTGGTT GGAAGATTCA AAGGCTAGGA AACCAGGAGC 3181 CACCAAAAGC GTAACTGGGG CCAGAGGATC CACTTTCAAG GTGGCAAGTT GGTTCCCCCC 3241 ATGTGGCTGC TTGAGTATCC TCACATGGCG GCTCACATCC TTCCAAGTAA GCAATGCAAA 3301 AGGCCAAGAA AGATGCTGCA AAGATGTTAT GACCTAGCCT CAGAAATCAC ACACCATCCC 3361 TGCCACCATT AGTAAGAAGT CCAGCCCACG TCCAGGAGAA GAGGAAGCAG ATTCCTCCTT 3421 TTGAAATGAA GAATATCAAG TAATTCGGGG GGCATATGAA AGCCACCACA CACCACAGGG 3481 ATCTTTTTAG AGCATACTTC TTATACCATC ACTGTAGTTC CTTAAGACTC AGGGGCAAAG 3541 CCTCACTTCC TTAGCACCCA GTGAAGACCA CGCTTACTCC CTCACTCAAC CTCTTGCTAC 3601 TTCCCACCTC TCCTGTCCAA CATCTAGTGT CACTTTCCAG AACATACCAA CAGCTTCCCC 3661 AGTTCTGTGC CTCTGCTCAG GCTGTTCCCC CTGCCTGGTC CACTTGTCCT CCTTCTTGTC 3721 CGGTCAAAAT GCTTCTTATC CTTCAAGACC CAGCTCTAGA GTCACCTCCA ACCCCTTACC 3781 CACCAGCCCC CTCTCCAAGT CTGTGTCCCA CAACCCCCCT GCTCCCTCCA GGGCACCCTC WO 00/09525 PCT/US99/17712 EPI-109 587 3841 CACCCTCTGG GCCACAGTTG TCAGGAGTCA GGCAGGGCAG GGGCCGGGTG GTGTCTTCTT 3901 TGTGTTCTTG CACTCAGGGC AGAGCTCAGC ACAGAGCAGA CGCTCAAAAA ACATTTAAAG 3961 GATAGAAGCA TTGATTTGTG GGTCCCCCAG TCTGGCTCCA GGATGCCAGC CAGCTGCTCC 4021 TAGAAGCAAA CGGACTTTTC CTGGGAAATC CCAGAGGTGA TGATCAGTAA TCTCTCCCGT 4081 GACTCGTAGT TCAGCTCTTC CTCCATGAGC CTGACTATCA GTGGACCTTC CAGAAAGAGC 4141 CCCTTTTCCT TCTCTCACCC ACAGCACAGG GCACTGGGAA AATGCCCAAT GAGTCCTGCC 4201 TCTGGGTTGT GCTTTGGACT TTTCAGTGTG TCTCGCATCC ACTCTTCAAC TTGAATGTTG 4261 CAACAGCCAT GAAAAAAGAA ATGCAAAGCG ATTCAGGATG AGAGCAATAC CCTACTCCAA 4321 AGAAGGCAAC ATAGAAGCTC AGAGAGATCA AGCAATTTGC CCAAGACCAC ACAGCTAGGA 4381 GTGGAACTCA TGGCTGTCCA AGCCCCATGC CTCTGCTGAA GGTAGAGATG AATTACAGCA 4441 ACAAGTCTAG AAAGGTGCCT GCCCTATGGT CTGTGAGTCT TGCCTAAGAA TGAAAGAGGA 4501 GCCAGTGGGT TAAAGATGAG GTCACCAACA ACGGTGGTGT TGGAGTTTAC CACTGATAAT 4561 AAGGGTGCAA AATGTAAATT ACTAATGTTT ATTGAGCCTA GTGCAGTGCG TGGGGCATTT 4621 TGCACATTGT CTCTGATCCC TATGACAACC CTGAGAGGTA GTGGTTTTAA CTGCCATGTT 4681 ACAGGTGAGG TCATTGTGGT TCAAGGACGT TAAGTAACTT CCCCAGCGTG ACACGGCTTA 4741 TAAGTAAGGC AGCCAGGATG TGAACCCAGT AGGACTATCT GGCTGCAAAG TCCCCACCCC 4801 CCTCGCCATC TGTATCCTCC AATCACTTCA GTGCTTTGCT GCATAGAAGG TAACGGAAAT 4861 CACGATGCCA CAGACTGTCC AGGAAGACAG AAACTAGGCA GATGGGCTGG CCATGGTCTC 4921 CAAGCCAGAC TGGAATCTCC AGGTCTGGAA TGATATCATT TTTCTCTTTT AATAAATTAA 4981 CTCACCCACC ACACGGCTTT GAGAGGCTCA AAGTTGACCA ACTCCCTTGG GAGGGCCCCG 5041 GTTGATAAGG AAGGAACGTG AATCCTCCCA TCACGGAAGC TTCAAGGAGG TCAAGGGTCC 5101 AACACTTGAG ATTGTTAGTG CTGTTGGTGG ATACTGGCCA AGGAAATATC CCAGTGGAGC 5161 CTCGAGATGA AGAACATGAG GCCCCCGTTT AGAACCAAGG ATCAGAGGGG GCTCTGTAAG 5221 ACCCAGGGGA GTCAGGTGCA CTGGAGCGCG GGCATGCAGA AAACAGCCTG AGCTCCACCT 5281 CGGCTTCTCC TTGTCCTGGC TGGTTGTCCT TAACCCCTGT CTCCTTCTGG ACCAGTTTTT 5341 GTCCTTCCCT TGTGACCGCT GAGGGGTAAC AGCCTCTTTC CACTTTCTTT CAGCGCCGAC 5401 ATGCTCAATG TCACCTTGCA AGGGCCCACT CTTAACGGGA CCTTTGCCCA GAGCAAATGC 5461 CCCCAAGTGG AGTGGCTGGG CTGGCTCAAC ACCATCCAGC CCCCCTTCCT CTGGGTGCTG 5521 TTCGTGCTGG CCACCCTAGA GAACATCTTT GTCCTCAGCG TCTTCTGCCT GCACAAGAGC 5581 AGCTGCACGG TGGCAGAGAT CTACCTGGGG AACCTGGCCG CAGCAGACCT GATCCTGGCC 5641 TGCGGGCTGC CCTTCTGGGC CATCACCATC TCCAACAACT TCGACTGGCT CTTTGGGGAG 5701 ACGCTCTGCC GCGTGGTGAA TGCCATTATC TCCATGAACC TGTACAGCAG CATCTGTTTC 5761 CTGATGCTGG TGAGCATCGA CCGCTACCTG GCCCTGGTGA AAACCATGTC CATGGGCCGG 5821 ATGCGCGGCG TGCGCTGGGC CAAGCTCTAC AGCTTGGTGA TCTGGGGGTG TACGCTGCTC 5881 CTGAGCTCAC CCATGCTGGT GTTCCGGACC ATGAAGGAGT ACAGCGATGA GGGCCACAAC 5941 GTCACCGCTT GTGTCATCAG CTACCCATCC CTCATCTGGG AAGTGTTCAC CAACATGCTC 6001 CTGAATGTCG TGGGCTTCCT GCTGCCCCTG AGTGTCATCA CCTTCTGCAC GATGCAGATC 6061 ATGCAGGTGC TGCGGAACAA CGAGATGCAG AAGTTCAAGG AGATCCAGAC GGAGAGGAGG 6121 GCCACGGTGC TAGTCCTGGT TGTGCTGCTG CTATTCATCA TCTGCTGGCT GCCCTTCCAG 6181 ATCAGCACCT TCCTGGATAC GCTGCATCGC CTCGGCATCC TCTCCAGCTG CCAGGACGAG 6241 CGCATCATCG ATGTAATCAC ACAGATCGCC TCCTTCATGG CCTACAGCAA CAGCTGCCTC 6301 AACCCACTGG TGTACGTGAT CGTGGGCAAG CGCTTCCGAA AGAAGTCTTG GGAGGTGTAC 6361 CAGGGAGTGT GCCAGAAAGG GGGCTGCAGG TCAGAACCCA TTCAGATGGA GAACTCCATG 6421 GGCACACTGC GGACCTCCAT CTCCGTGGAA CGCCAGATTC ACAAACTGCA GGACTGGGCA 6481 GGGAGCAGAC AGTGAGCAAA CGCCAGCAGG GCTGCTGTGA ATTTGTGTAA GGATTGAGGG 6541 ACAGTTGCTT TTCAGCATGG GCCCAGGAAT GCCAAGGAGA CATCTATGCA CGACCTTGGG 6601 AAATGAGTTG ATGTCTCCGG TAAAACACCG GAGACTAATT CCTGCCCTGC CCAATTTTGC 6661 AGGGAGCATG GCTGTGAGGA TGGGGTGAAC TCACGCACAG CCAAGGACTC CAAAATCACA 6721 ACAGCATTAC TGTTCTTATT TGCTGCCACA CCTGAGCCAG CCTGCTCCTT CCCAGGAGTG 6781 GAGGAGGCCT GGGGGCAGGG AGAGGAGTGA CTGAGCTTCC CTCCCGTGTG TTCTCCGTCC 6841 CTGCCCCAGC AAGACAACT.T AGATCTCCAG GAGAACTGCC ATCCAGCTTT GGTGCAATGG 6901 CTGAGTGCAC AAGTGAGTTG TTGCCCTGGG TTTCTTTAAT CTATTCAGCT AGAACTTTGA 6961 AGGACAATTT CTTGCATTAA TAAAGGTTAA GCCCTGAGGG GTCCCTGATA ACAACCTGGA 7021 GACCAGGATT TTATGGCTCC CCTCACTGAT GGACAAGGAG GTCTGTGCCA AAGAAGAATC 7081 CAATAAGCAC ATATTGAGCA CTTGCTGTAT ATGCAGTATT GAGCACTGTA GGCAAGAGGG 7141 AAGAAAGAGA AGGAGCCATC TCCATCTTGA AGGAACTCAA AGACTCAAGT GGGAACGACT 7201 GGGCACTGCC ACCACCAGAA AGCTGTTCGA TGAGACGGTC GAGCAGGGTG CTGTGGGTGA 7261 TATGGACAGC AGAAGGGGGA GCCAGGTTCC AGCTCACCAA TACTATTGCA CACCACCTGT 7321 CCTGCCTC (2) INFORMATION FOR SEQ ID NO:2442: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 241 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2442: 1 GCCCTTCAAA GATGAGCTGT TCCCGCCGCC ACTCCAGCTC TGGCTTCTGG GCTCCGAGGA 61 GGGGTGGGGA CGGTGGTGAC GGTGGGGACA TCAGGCTGCC CCGCAGTACC AGGGAGCGAC WO 00/09525 PCT/US99/17712 EPI-109 588 121 TGAAGTGCCC ATGCCGCTTG CTCCGGAGAA GGTGGGTGCC GGGCAGGGGC TGCTCCAGCC 181 GCCTCACCTC TGCTGGGAGG ACAAACTGTC CCAGCACAGA GGGAGGGAGG GAGGGCAGGC 241 AGCGGGGAGA AGTTTCCCTG TGGTCGTGGG GAGTT (2) INFORMATION FOR SEQ ID NO:2443: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1441 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2443: 1 GAGCTCTTCA ATATTTTAGT GAAAGCTATA GATGAGGCTC CATAGGGGAT AAAGCACAGA 61 CACACCTTTT CAGAGGGCTT GTGGACTCTG GGCAGCCTGT CCATAGACCT CTGTCCCCAA 121 CTGGCAAGTC AGGAAACTCC AGATTAAGGA GCCCCAATGT GGTTGAACAG CCAGGTGCAC 181 AGATGAGTCA ACCACACAGC CAGGCCAGGG AGGGCCTTCA CTCAAGAGCC TACAGCCAGT 241 TCACAGCCAA GCCAGGGCTA GCGCCAGGCC ACCCATAAAC TGATCTGAGA CTCTGTTTCC 301 CTGTCTCCAT GATGATGGGA TCAGGCTTGA TTGCTGGTTT GTAGGCTTGT TATGAATCAA 361 GTCACAGGGA AGAGGAGCTG ATGGGCTGGG GGGACGTCCT CTGGCCCTCC TGTCTCTTCC 421 CCAGATCCAC TGGGCCCACT CTTATCTGTT CTCTTCTGAA GGAAGGGTTT TAAGGCTTCA 481 AAAAAAAATG TTTTGAAAGT CCCTGCCCTT TCCAGCTCCT ACCGTCTCAG CCCTGGGAGT 541 GTAAAGTGCT GCAGATAGTT AGTAAGTCTT TGAGCAAAAC TGAGAAAGCC AGCCTGAGCC 601 TTGACATGGG AGAAACCTCC GCCATACATC TCCGAAGAAA CGGCCGCGTG TCTCAGGGGA 661 GCGCAAACAC CCGTACCCAG GAAACAGGAC AGCTTCTGCC ACTGTCGCCC TTGGGAGCCG 721 TACGTGGCAT GACAAAGAAA TCCCAGGACT CCGCCTGCCC ACCTGGCCAC CCTCTGTTTA 781 CACCTTCCGC GTAAACGCCC ACTGTTTACA TCCAAAACTC AGACACAAAA TAACCACCTC 841 AAGAAGATAA ATAATGATAA GAAATAAATG TTACGCGAGG CAAATTTATT CACATGGGGC 901 TTCCCAGGCC ACTTTGTGGT CAGCCGGGAG GGACGTTTTT GCCGTCCCAC GACTCCAACG 961 GGCAGCCGGG CCTACGCAAA CATGGAAATC TTCCAAGAGC CTCCCTGGCC CCCAGGGCTC 1021 AGAGGGTGGC AGAGCGGAGA GCGAAGGTGG CCGCAGCCTT CCCGGCCCCA CAGCCAGCCT 1081 GGCTCCAGCT GGGCAGGAGT GCAGAGCTCA GCTGGAGGCG AGGGGGAAGT GCCCAGGAGG 1141 CTGATGACAT CACTACCCAG CCCTTCAAAG ATGAGCTGTT CCCGCCGCCA CTCCAGCTCT 1201 GGCTTCTGGG CTCCGAGGAG GGGTGGGGAC GGTGGTGACG GTGGGGACAT CAGGCTGCCC 1261 CGCAGTACCA GGGAGCGACT GAAGTGCCCA TGCCGCTTGC TCCGGAGAAG GTGGGTGCCG 1321 GGCAGGGGCT GCTCCAGCCG CCTCACCTCT GCTGGGAGGA CAAACTGTCC CAGCACAGAG 1381 GGAGGGAGGG AGGGCAGGCA GCGGGGAGAA GTTTCCCTGT GGTCGTGGGG AGTTGGGAAA 1441 AGTTCCCTTC CTTCCGGAGG GAGG (2) INFORMATION FOR SEQ ID NO:2444: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 2581 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2444: 1 CAGATTCACA AACTGCAGGA CTGGGCAGGG AGCAGACAGT GAGCAAACGC CAGCAGGGCT 61 GCTGTGAATT TGTGTAAGGA TTGAGGGACA GTTGCTTTTC AGCATGGGCC CAGGAATGCC 121 AAGGAGACAT CTATGCACGA CCTTGGGAAA TGAGTTGATG TCTCCGGTAA AACACCGGAG 181 ACTAATTCCT GCCCTGCCCA ATTTTGCAGG GAGCATGGCT GTGAGGATGG GGTGAACTCA 241 CGCACAGCCA AGGACTCCAA AATCACAACA GCATTACTGT TCTTATTTGC TGCCACACCT 301 GAGCCAGCCT GCTCCTTCCC AGGAGTGGAG GAGGCCTGGG GGGAGGGAGA GGAGTGACTG 361 AGCTTCCCTC CCGTGTGTTC TCCGTCCCTG CCCCAGCAAG ACAACTTAGA TCTCCAGGAG 421 AACTGCCATC CAGCTTTGGT GCAATGGCTG AGTGCACAAG TGAGTTGTTG CCCTGGGTTT 481 CTTTAATCTA TTCAGCTAGA ACTTTGAAGG ACAATTTCTT GCATTAATAA AGGTTAAGCC 541 CTGAGGGGTC CCTGATAACA ACCTGGAGAC CAGGATTTTA TGGCTCCCCT CACTGATGGA 601 CAAGGAGGTC TGTGCCAAAG AAGAATCCAA TAAGCACATA TTGAGCACTT GCTGTATATG 661 CAGTATTGAG CACTGTAGGC AAGACCCAAG AAAGAGAAGG AGCCATCTCC ATCTTGAAGG 721 AACTCAAAGA CTCAAGTGGG AACGACTGGG CACTGCCACC ACCAGAAAGC TGTTCGACGA 781 GACGGTCGAG CAGGGTGCTG TGGGTGATAT GGACAGCAGA AGGGGGAGAC CAAGGTTCCA 841 GCTCAACCAA TAACTATTGC ACAACCACCT GTCCCTGCCT CAGTTCCCTT TTATGTAACA 901 TGAAGTCGTT GTGAGGGTTA AAGGCAGTAA CAGGTATAAA GTACTTAGAA AAGCAAAGGG 961 TGCTACGTAC ATGTGAGGCA TCATTACGCA GACGTAACTG GGATATGTTT ACTATAAGGA 1021 AAAGACACTG AGGTCTAGAA ATAGCTCCGT GGAGCAGAAT CAGTATTGGG AGCCGGTGGC 1081 GGTGTGAAGC ACCAGTGTCT GGCACACAGT AGGTGCTCAT TGGCTCCCTT CCACCTGTCA 1141 TTCCCACCAC CCTGAGGCCC CAACCGCCAC ACACACAGGA GCATTTGGAG AGAAGGCCAT 1201 GTCTTCAAAG TCTGATTTGT GATGAGGCAG AGGAAGATAT TTCTAATCGG TCTTGCCCAG 1261 AGGATCACAG TGCTGAGACC CCCCACCACC AGCCGGTACC TGGGAAGGGG GAGAGTGCAG 1321 GCCTGCTCAG GGACTGTTCC TGTCTCAGCA ACCAAGGGAT TGTTCCTGTC AATCAATGGT 1381 TTATTGGAAG GTGGCCCAGT ATGAGCCCTA GAAGAGTGTG AAAAGGAATG GCAATGGTGT 1441 TCACCATCGG CAGTGCCAGG GCAGCACTCA TTCACTTGAT AAATGAATAT TTATTAGCTG WO 00/09525 PCT/US99/17712 EPI-109 589 1501 GTTGGAGAGC TAGAACCTGG AGAGCTAGAA CCTGGAGAAC TAGAACCTGG AGGGCTAGAA 1561 CCTGGAGAGG CTAGAACCAA GAAGGGCTAG AACCTGGAGG GGCTAGAACC TAGAGAAGCT 1621 AAAACCTGAG CTAGAAGCTG GAGGACTAGA ACCTGGAGGG CTGGAATCTG AAGGGCTAGA 1681 ACCTGGAGGG CTGGAATCTG GAGAGCTAGA ACCTGGAGGG CTAGAACCTG GAGGGCTAGA 1741 ACCTAGAAGG GCTAGAACCT GGAGGGCTGG AATCTGGAGA GCTAGAACCT GGAGGGCTAG 1801 AACCTGGAGG GCTAGAACCT AGAAGGGCTA GAACCTGGAG GGCTAGAACC TGGCAGGTTA 1861 GAACCTAGAA GGGCTAGAAC CTGGAGAGCC AGAACCTGGA GGGCTAGAAC CTGGAAGGGC 1921 TAGAACCTGT AGAGCTAGAA CATGGAGAGC TAGAACCCGG CAGGCTAGAA CCTGGCAAGC 1981 TAGAACCTGG AGGGAATGAA CCTGGAGGGC TAGAACCTGG AGAATGAGAA AAATTTACAT 2041 GGCAAAGAGC CCATAAATCC TGACCAATCC AACTCTGAAT TTTAAAGCAA AAGCGTGAAA 2101 AAAAAGATTC CCTCCTTACC CCCAACCCAC TCTTTTTTCC CACCACCCAC TCTCCTCTGC 2161 CTCAGTAAGT ATCTGGAGGA AGAAAACAGG TGAAAGAAGA AGTAAAAACC ATTTAGTATT 2221 AGTATTAGAA TGAAGTCAAA CTGTGCCACA CATGGTGAAT GAAAAAAAAA AAAAAGAGGC 2281 TGTGTTTTGT CACACAGGGC AGTCATTCAG CACCAGAGCA CGTGATGGTC TGAGACTCTC 2341 TTAGGAGCAG AGCTCTGCCG CAATGGCCAT GTGGGGATCC ACACCTGGTC TGAGGGGCAA 2401 CTGAGTCTGC GGGAGAAGAG CGGCCCTATG CATGGTGTAG ATGCCCTGAT AAAGAACATC 2461 TGTCCTGTGA AAGACTCAAT GAGCTGTTAT GTTGTAAACA GGAAGCATTT CACATCCAAA 2521 CGAGAAAATC ATGTAAACAT GTGTCTTTTC TGTAGAGCAT AATAAATGGA TGAGGTTTTT 2581 GCAAAAAAAA AAAAAAAAA (2) INFORMATION FOR SEQ ID NO:2445: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 7321 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2445: 1 AAATGATAGA CCGTCAATAA TTTGTTAAAT GCTTTTTAAA ATGAATGCTT TAAGCCGGGT 61 GCAGTGCCTC ACATCTGTAA TCCCAGCACT TTGGAGCCGA GCGGGTGGAT TGTGTGAGGT 121 CAGGAGTTCG AGACCAACCT GGCCAACATG GCAAAACCTC ACTCTCTACC AAAAATACAA 181 AAATTAGCCA GGCATGGTGG CAGGCACCTG TGATCCCAGC TACTCAGGAG GCTGAGACAG 241 GAGAATCGCT TGAACCCGGG AGGCAAGGTT GCAGTGAGCC AAGATTACGC CATTGTACTC 301 CAGCCTGGGT GACAGAGAGA GACTCCGTCT CAAAAAAAAA AAAAAAAAAA AAAAAATTAC 361 GCTTCAAACA CATGATCTCT CACCACTGTT GAATTTTCTT TCTATGAGCC CAGGAGGGCC 421 TCTCAGAGAG GAAAGCTCCT AGGTCTTCCT TTCCCTCTGC AAACTCCCTG CCTTGAAGGT 481 TCAGAAGGAC TGTGCGTGCT CGTTGCATCC TTTGCAAGTG TCCAAACCCT GATCCCAGCT 541 GTGCTTAGGG GTTCCTGCAA ACCTTTTCCA GGTGTTAATT ACCTCCCACT TCATTTCCTG 601 TTTACCAACT CAGCTTTTTG TTTTAGTGTG TTTGAATTCC CTGAACTGAC CGTTGTCTGA 661 TCTCCACCTC CCAACTGAAT TAGGGGAGCT GGGCTTCTGG AAACCCAGGT GCCGGGTGTT 721 GCAGAGTGGC TGAAAGCTGG GATGTGGCAG ATCCGTGGCT ACATTCATGC ACACACACAC 781 ACCCACATAC CCACACATGC ACACACACAC ACACACCCGC ACTCACACAC TTGGACATGC 841 ATAGACCACA GCTTTCCACA CCCTTCCTAG ACAGGGGTCA CTTGGTATCC TGGAGAGAGT 901 GTGAAGTCCT GGAATGGAAA GAGGGGGGAT TAAGCCCCAC CTCTAGCCAT GGGACTGAGA 961 CAAGTCACCA CCAACCCATC TGCGCCTTGT TTACCTCCTC TGTGAGGCAA GCACAGAGCC 1021 CATGCCTGCC CCCCTGGATG GGAGTGATGT GAAACTTGAA GGGCGGTCAG AGCAAGGGTC 1081 GGGAATGGAA GGCCCTTGGG AAAAAAGGCC CTTTCAACTA GGGGCACAGA GGAGGCCCTG 1141 GGCTGAGAAC TTGACAGCAC CTTGTAATTG GTAAGCCAAG CCCGAAGGGA CTGGAAATAC 1201 TCAGATGTGT CTGTCTCCCT TATTAGGTTC AAAGTCCCTC AAGACCCTGT CTCCATCACA 1261 GTGCTCCAGT CCAGACCCCT CCTCTGAGCT CCAGACCCTG CTGGACCCAA CCAGCCCTAT 1321 GGGGTCGCAT CCCCACCTGC CTGGAATTCT CCAAAGAACC TCCCCTTTAA CAGTTCCAGC 1381 CTTTAACAGT TCCAGTCTAA ACACATGACC TTTCTCCTCT AAATCAGCCC CCCATCTCTG 1441 CCTTTGCAGG AGATGGAAGC CATGACACCT GCCTCGCCCC TGTCCTCACC CCATCCATGT 1501 CCAATCAAGC ACTAGGCATG TCAGGTTTAC CCTCTAAACT CCTCTGGAAT CCAGTCTCTC 1561 AGTCTCCATC ATCCCAGGTC GAAGCTAATG GGCTAACTGG TCCTTGCTTC CACTCTACCC 1621 CCACTGCAGT CCTGACTTCC TGAGCAGCAG CCAGGGCCTA ATCGATATTC ACACCAAGCG 1681 CCAACCTGAC TGAGATATCC TCCTGCACCA TCATCCCTCC ACCCTGTTTA GTTCTGCTCA 1741 CCCTCAGTGT TCTCATCAAT AATCCACTCC CCTCACAGGC GCGTTTGGGA CCCCATGTTC 1801 TATGCTCTCA CAGGACCTTT TGCTTGATTT TTCACTGTAC TTAGGTCAGT TTGCAGTTAT 1861 TAAGTGACTG AGCAATGTCT GGCTTCTCCA GTAGACTGTC AGCTCCTAGC CATTGTATAC 1921 CTAGCACCGC TGTGTGGGAG CACGTGACAA ACGTCCAGTG AGTCAGGGAC TCAGCAGTCT 1981 CCATTTCTCC GCCCTGCTGG AGAATGCGTG TATTTGGCAA TCCCCAGCCC CTGTGCCATC 2041 TAACCATCTT TTCTTCTCTG TTCAGCCCAG GTGTGGCCTC ACTCACATCC CACTCTGAGT 2101 CCAAATGTTC TCTCCCTGGA AGATATCAAT GTTTCTGTCT GTTCGTGAGG ACTCCGTGCC 2161 CACCACGGCC TCTTTCAGGT GAGTCAAAGG GATTCCTCAG TTCACTAGTT AGGGGAGGTG 2221 GGCAGACACC CTGGAGAACT CCCTGGAAAG CTCAACTCTC ATGCCCCGGA CAACAGTTGA 2281 AGGAACCATG GTGATGTTAA GCCCAAAGAC AAAACCTCTC AGGTGTCCAA GTCCCTGTTG 2341 GAATCTTGGG AGCAGAGGGA ATGTTCTGTG GTCTAGAGGA AGAGGGGCTC AGGGAGGAGA 2401 AGGGCACATT CCTGGTTGTT ATATGTTTCT ATCTATCCCA GATGAACTTG GAAGTGAAGG 2461 GAAGAGAGTT AAACATTAAA GTAAATACCC AGTGGATCAG ACAGCAATGT GCCAGATTGC WO 00/09525 PCTUS99/17712 EPI-109 590 2521 CTTGGAAACA AAATATCTCC AACACATGGC TGACATTTGG TGGGAGATCA GAACACCCTA 2581 AAGAGAGAAT TTAAGGGGAG GGGGAGGAGG ACCTGAGCCA GAGTAGAAGC AGAGGATAGG 2641 GAGATCTGTT CTTGGGGACA GCATTTGCAA GAAACAAGGC TGAGGGGTCC ACTCCAACCT 2701 CTCCACCCTG CTGCAGGTGC TGCCTATGAT GAAGATGAGC AGATGGCCAT CTCAGCTGGG 2761 GCCACAGTGC ACTGGACCTA TAGTTTCCAA TTCCGCACTC AGCAGGCATC TTTCTGATGA 2821 TCCGATGGCT TCTCAGAGCC AGGGATGGGC CAGGATCCAT CCCCTTGGCT ACTGTCTTGC 2881 TGAGAAATTT ATAAGCAGCA TCTGGTGCTA TACTTTGGTC TCTAGTGAGT TAGCTCATGA 2941 AAGATGATAG ACTCTCCAAG CCAGGGGTAT GCAGGAAATG GGTTTTCTGT AGCTACAGAA 3001 ATGGGGTTGA GGGTTGGACC AAGGGACTAC CCAGGGGAAG TCTTACCTTC AGAGGACTCT 3061 GGAAAGGAGG CTGCAAGTTT TCATGGGTCA AGAATTCAGA GCCCAGTAGA GACAGCTTAT 3121 CTCTGTTCCA AGATGTCTGG GGCCTTGGTT GGAAGATTCA AAGGCTAGGA AACCAGGAGC 3181 CACCAAAAGC GTAACTGGGG CCAGAGGATC CACTTTCAAG GTGGCAAGTT GGTTCCCCCC 3241 ATGTGGCTGC TTGAGTATCC TCACATGGCG GCTCACATCC TTCCAAGTAA GCAATGCAAA 3301 AGGCCAAGAA AGATGCTGCA AAGATGTTAT GACCTAGCCT CAGAAATCAC ACACCATCCC 3361 TGCCACCATT AGTAAGAAGT CCAGCCCACG TCCAGGAGAA GAGGAAGCAG ATTCCTCCTT 3421 TTGAAATGAA GAATATCAAG TAATTCGGGG GGCATATGAA AGCCACCACA CACCACAGGG 3481 ATCTTTTTAG AGCATACTTC TTATACCATC ACTGTAGTTC CTTAAGACTC AGGGGCAAAG 3541 CCTCACTTCC TTAGCACCCA GTGAAGACCA CGCTTACTCC CTCACTCAAC CTCTTGCTAC 3601 TTCCCACCTC TCCTGTCCAA CATCTAGTGT CACTTTCCAG AACATACCAA CAGCTTCCCC 3661 AGTTCTGTGC CTCTGCTCAG GCTGTTCCCC CTGCCTGGTC CACTTGTCCT CCTTCTTGTC 3721 CGGTCAAAAT GCTTCTTATC CTTCAAGACC CAGCTCTAGA GTCACCTCCA ACCCCTTACC 3781 CACCAGCCCC CTCTCCAAGT CTGTGTCCCA CAACCCCCCT GCTCCCTCCA GGGCACCCTC 3841 CACCCTCTGG GCCACAGTTG TCAGGAGTCA GGCAGGGCAG GGGCCGGGTG GTGTCTTCTT 3901 TGTGTTCTTG CACTCAGGGC AGAGCTCAGC ACAGAGCAGA CGCTCAAAAA ACATTTAAAG 3961 GATAGAAGCA TTGATTTGTG GGTCCCCCAG TCTGGCTCCA GGATGCCAGC CAGCTGCTCC 4021 TAGAAGCAAA CGGACTTTTC CTGGGAAATC CCAGAGGTGA TGATCAGTAA TCTCTCCCGT 4081 GACTCGTAGT TCAGCTCTTC CTCCATGAGC CTGACTATCA GTGGACCTTC CAGAAAGAGC 4141 CCCTTTTCCT TCTCTCACCC ACAGCACAGG GCACTGGGAA AATGCCCAAT GAGTCCTGCC 4201 TCTGGGTTGT GCTTTGGACT TTTCAGTGTG TCTCGCATCC ACTCTTCAAC TTGAATGTTG 4261 CAACAGCCAT GAAAAAAGAA ATGCAAAGCG ATTCAGGATG AGAGCAATAC CCTACTCCAA 4321 AGAAGGCAAC ATAGAAGCTC AGAGAGATCA AGCAATTTGC CCAAGACCAC ACAGCTAGGA 4381 GTGGAACTCA TGGCTGTCCA AGCCCCATGC CTCTGCTGAA GGTAGAGATG AATTACAGCA 4441 ACAAGTCTAG AAAGGTGCCT GCCCTATGGT CTGTGAGTCT TGCCTAAGAA TGAAAGAGGA 4501 GCCAGTGGGT TAAAGATGAG GTCACCAACA ACGGTCGTGT TGGAGTTTAC CACTGATAAT 4561 AAGGGTGCAA AATGTAAATT ACTAATGTTT ATTGAGCCTA GTGCAGTGCG TGGGGCATTT 4621 TGCACATTGT CTCTGATCCC TATGACAACC CTGAGAGGTA GTGGTTTTAA CTGCCATGTT 4681 ACAGGTGAGG TCATTGTGGT TCAAGGACGT TAAGTAACTT CCCCAGCGTG ACACGGCTTA 4741 TAAGTAAGGC AGCCAGGATG TGAACCCAGT AGGACTATCT GGCTGCAAAG TCCCCACCCC 4801 CCTCGCCATC TGTATCCTCC AATCACTTCA GTGCTTTGCT GCATAGAAGG TAACGGAAAT 4861 CACGATGCCA CAGACTGTCC AGGAAGACAG AAACTAGGCA GATGGGCTGG CCATGGTCTC 4921 CAAGCCAGAC TGGAATCTCC AGGTCTGGAA TGATATCATT TTTCTCTTTT AATAAATTAA 4981 CTCACCCACC ACACGGCTTT GAGAGGCTCA AAGTTGACCA ACTCCCTTGG GAGGGCCCCG 5041 GTTGATAAGG AAGGAACGTG AATCCTCCCA TCACGGAAGC TTCAAGGAGG TCAAGGGTCC 5101 AACACTTGAG ATTGTTAGTG CTGTTGGTGG ATACTGGCCA AGGAAATATC CCAGTGGAGC 5161 CTCGAGATGA AGAACATGAG GCCCCCGTTT AGAACCAAGG ATCAGAGGGG GCTCTGTAAG 5221 ACCCAGGGGA GTCAGGTGCA CTGGAGCGCG GGCATGCAGA AAACAGCCTG AGCTCCACCT 5281 CGGCTTCTCC TTGTCCTGGC TGGTTGTCCT TAACCCCTGT CTCCTTCTGG ACCAGTTTTT 5341 GTCCTTCCCT TGTGACCGCT GAGGGGTAAC AGCCTCTTTC CACTTTCTTT CAGCGCCGAC 5401 ATGCTCAATG TCACCTTGCA AGGGCCCACT CTTAACGGGA CCTTTGCCCA GAGCAAATGC 5461 CCCCAAGTGG AGTGGCTGGG CTGGCTCAAC ACCATCCAGC CCCCCTTCCT CTGGGTGCTG 5521 TTCGTGCTGG CCACCCTAGA GAACATCTTT GTCCTCAGCG TCTTCTGCCT GCACAAGAGC 5581 AGCTGCACGG TGGCAGAGAT CTACCTGGGG AACCTGGCCG CAGCAGACCT GATCCTGGCC 5641 TGCGGGCTGC CCTTCTGGGC CATCACCATC TCCAACAACT TCGACTGGCT CTTTGGGGAG 5701 ACGCTCTGCC GCGTGGTGAA TGCCATTATC TCCATGAACC TGTACAGCAG CATCTGTTTC 5761 CTGATGCTGG TGAGCATCGA CCGCTACCTG GCCCTGGTGA AAACCATGTC CATGGGCCGG 5821 ATGCGCGGCG TGCGCTGGGC CAAGCTCTAC AGCTTGGTGA TCTGGGGGTG TACGCTGCTC 5881 CTGAGCTCAC CCATGCTGGT GTTCCGGACC ATGAAGGAGT ACAGCGATGA GGGCCACAAC 5941 GTCACCGCTT GTGTCATCAG CTACCCATCC CTCATCTGGG AAGTGTTCAC CAACATGCTC 6001 CTGAATGTCG TGGGCTTCCT GCTGCCCCTG AGTGTCATCA CCTTCTGCAC GATGCAGATC 6061 ATGCAGGTGC TGCGGAACAA CGAGATGCAG AACTTCAAGG AGATCCAGAC GGAGAGGAGG 6121 GCCACGGTGC TAGTCCTGCT TGTGCTGCTG CTATTCATCA TCTGCTGGCT CCCTTCCAG 6181 ATCAGCACCT TCCTGGATAC GCTGCATCGC CTCGGCATCC TCTCCAGCTG CCAGGACGAG 6241 CGCATCATCT ATGTAATCAC ACAGATCGCC TCCTTCATGG CCTACAGCAA CAGCTGCCTC 6301 AACCCACTGG TGTACGTGAT CGTGGGCAAG CGCTTCCGAA AGAAGTCTTG GGAGGTGTAC 6361 CAGGGAGTGT GCCAGAAAGG GGGCTGCAGG TCAGAACCCA TTCAGATGGA GAACTCCATG 6421 GGCACACTGC GGACCTCCAT CTCCGTGGAA CGCCAGATTC ACAAACTGCA GACTGGGCA 6481 GGGAGCAGAC AGTGAGCAAA CGCCAGCAGG GCTGCTGTGA ATTTGTGTAA GGATTGAGGG 6541 ACAGTTGCTT TTCAGCATGG GCCCAGGAAT CCAAGGAGA CATCTATGCA CGACCTTGGG WO 00/09525 PCT/US99/17712 EPI-109 591 6601 AAATGAGTTG ATGTCTCCGG TAAAACACCG GAGACTAATT CCTGCCCTGC CCAATTTTGC 6661 AGGGAGCATG GCTGTGAGGA TGGGGTGAAC TCACGCACAG CCAAGGACTC CAAAATCACA 6721 ACAGCATTAC TGTTCTTATT TGCTGCCACA CCTGAGCCAG CCTGCTCCTT CCCAGGAGTG 6781 GAGGAGGCCT GGGGGCAGGG AGAGGAGTGA CTGAGCTTCC CTCCCGTGTG TTCTCCGTCC 6841 CTGCCCCAGC AAGACAACTT AGATCTCCAG GAGAACTGCC ATCCAGCTTT GGTGCAATGG 6901 CTGAGTGCAC AAGTGAGTTG TTGCCCTGGG TTTCTTTAAT CTATTCAGCT AGAACTTTGA 6961 AGGACAATTT CTTGCATTAA TAAAGGTTAA GCCCTGAGGG GTCCCTGATA ACAACCTGGA 7021 GACCAGGATT TTATGGCTCC CCTCACTGAT GGACAAGGAG GTCTGTGCCA AAGAAGAATC 7081 CAATAAGCAC ATATTGAGCA CTTGCTGTAT ATGCAGTATT GAGCACTGTA GGCAAGAGGG 7141 AAGAAAGAGA AGGAGCCATC TCCATCTTGA AGGAACTCAA AGACTCAAGT GGGAACGACT 7201 GGGCACTGCC ACCACCAGAA AGCTGTTCGA TGAGACGGTC GAGCAGGGTG CTGTGGGTGA 7261 TATGGACAGC AGAAGGGGGA GCCAGGTTCC AGCTCACCAA TACTATTGCA CACCACCTGT 7321 CCTGCCTC (2) INFORMATION FOR SEQ ID NO:2446: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 2221 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2446: 1 CTGCAGAAAA CAGCCTGAGC TCCACCTCGG CTTCTCCTTG CCCTGGCTGG TTGTCCTTAA 61 CCCCTGTCTC CTTCTGGACC AGTTTTTGTC CTTCCCTTGT GACCCTGAGG GGTAACAGCC 121 TCTTTTCCAC TTTCTTTCAG CGCCGACATG CTCAATGTCA CCTTGCAAGG GCCCACTCTT 181 AACGGGACCT TTGCCCAGAG CAAATGCCCC CAAGTGGAGT GGCTGGGCTG GCTCAACACC 241 ATCCAGCCCC CCTTCCTCTG GGTGCTGTTC GTGCTGGCCA CCCTAGAGAA CATCTTTGTC 301 CTCAGCGTCT TCTGCCTGCA CAAGAGCAGC TGCACGGTGG CAGAGATCTA CCTGGGGAAC 361 CTGGCCGCAG CAGACCTGAT CCTGGCCTGC GGGCTGCCCT TCTGGGCCAT CACCATCTCC 421 AACAACTTCG ACTGGCTCTT TGGGGAGACG CTCTGCCGCG TGGTGAATGC CATTATCTCC 481 ATGAACCTGT ACAGCAGCAT CTGTTTCCTG ATGCTGGTGA GCATCGACCG CTACCTGGCC 541 CTGGTGAAAA CCATGTCCAT GGGCCGGATG CGCGGCGTGC GCTGGGCCAA GCTCTACAGC 601 TTGGTGATCT GGGGGTGTAC GCTGCTCCTG AGCTCACCCA TGCTGGTGTT CCGGACCATG 661 AAGGAGTACA GCGATGAGGG CCACAACGTC ACCGCTTGTG TCATCAGCTA CCCATCCCTC 721 ATCTGGGAAG TGTTCACCAA CATGCTCCTG AATGTCGTGG GCTTCCTGCT GCCCCTGAGT 781 GTCATCACCT TCTGCACGAT GCAGATCATG CAGGTGCTGC GGAACAACGA GATGCAGAAG 841 TTCAAGGAGA TCCAGACGGA GAGGAGGGCC ACGGTGCTAG TCCTGGTTGT GCTGCTGCTA 901 TTCATCATCT GCTGGCTGCC CTTCCAGATC AGCACCTTCC TGGATACGCT GCATCGCCTC 961 GGCATCCTCT CCAGCTGCCA GGACGAGCGC ATCATCGATG TAATCACACA GATCGCCTCC 1021 TTCATGGCCT ACAGCAACAG CTGCCTCAAC CCACTGGTGT ACGTGATCGT GGGCAAGCGC 1081 TTCCGAAAGA AGTCTTGGGA GGTGTACCAG GGAGTGTGCC AGAAAGGGGG CTGCAGGTCA 1141 GAACCCATTC AGATGGAGAA CTCCATGGGC ACACTGCGGA CCTCCATCTC CGTGGAACGC 1201 CAGATTCACA AACTGCAGGA CTGGGCAGGG AGCAGACAGT GAGCAAACGC CAGCAGGGCT 1261 GCTGTGAATT TGTGTAAGGA TTGAGGGACA GTTGCTTTTC AGCATGGGCC CAGGAATGCC 1321 AAGGAGACAT CTATGCACGA CCTTGGGAAA TGAGTTGATG TCTCCGGTAA AACACCGGAG 1381 ACTAATTCCT GNCCTGCCCA ATTTTGCAGG GAGCATGGCT GTGAGGATGG GGTGAACTCA 1441 CGCACAGCCA AGGACTCCAA AATCACAACA GCATTACTGT TCTTATTTGC TGCCACACCT 1501 GAGCCAGCCT GCTCCTTCCC AGGAGTGGAG GAGGCCTGGG GGCAGGGAGA GGAGTGACTG 1561 AGCTTCCCTC CCGTGTGTTC TCCGTCCCTG CCCCAGCAAG ACAACTTAGA TCTCCAGGAG 1621 AACTGCCATC CAGCTTTGGT GCAATGGCTG AGTGCACAAG TGAGTTGTTG CCCTGGGTTT 1681 CTTTAATCTA TTCAGCTAGA ACTTTGAAGG ACAATTTCTT GCATTAATAA AGGTTAAGCC 1741 CTGAGGGGTC CCTGATAACA ACCTGGAGAC CAGGATTTTA TGGCTCCCCT CACTGATGGA 1801 CAAGGGAGGT CTGTGCCAAA GAAGAATCCA ATAAGCACAT ATTGAGCACT TGCTGTATAT 1861 GCAGTATTGA GCACTGTAGG CAAGAGGGAA GAAAGAGAAG GAGCCATCTC CATCTTGAAG 1921 GAACTCAAAG ACTCAAGTGG GAACGACTGG CACTGCCACC ACCAGAAAGC TGTTCGACGA 1981 GACGGTCGAG CAGGGTGCTG TGGGTGATAT GGACAGCAGA AGGGGGAGAC CAAGGTTCCA 2041 GCTCAACCAA TAACTATTGC ACAACCACCT GTCCCTGCCT CAGTTCCCTC TTCTGTAACA 2101 TGAAGTCGTT GTGAGGGTTA AAGGCAGTAA CAGGTATAAA GTACTTAGAA AAGCAAAGGG 2161 TGCTACGTAC ATGTGAGGCA TCATTACGCA GACGTAACTG GGATATGTTT ACTATAAGGA 2221 AAAGACACTG AGGTCTAGA (2) INFORMATION FOR SEQ ID NO:2447: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 2461 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2447: 1 TGATCCTATC ACAACCTGAG AGTAGTTTTT ACTCCATTTA CAGGTGAGGT CATTGTGGTT 61 CAAGGACGTT AAGTAACTTC CCCAGCTCAC ACGGCTTATA AGTAAGGCAG CCAGGATGTG WO 00/09525 PCT/US99/17712 EPI-109 592 121 AACCCAGTAG GACTATCTGG CTGCAAAGTC CCCACCCTCC CTCGCCATCT GTATCCTCCA 181 ATCATCTTCA GTGCTTTGCT GATAGAAGGT ACGGAAATAC GATGCCACAG ACTGTCCAGG 241 AAGACAGAAA CTAGGCAGAT GGGCTGGCCA TGGTCTCCAA GCCAGACTGG AATCTCCAGG 301 TCTGGAATGA TATCATTTTT CTCTTTTAAT AAATTAACTC ACCCACCACA CGGCTTTGAG 361 AGGCTCAAAG GTGACCAACT CCCTTGGGAG GGCCCCGGTT GATAAGGAAG GAATGTGAAT 421 CCTCCCATCA CGGAAGCTTC AAGGAGGTCA AGGGTCCAAC ACTTGAGATT GTTAGTGCTG 481 TTGGTGGATA CTGCAGAATA TCCAGTGGAG CCTCAGATGA AGAACATGAG GCCCCGTTTA 541 GATCCAAGGA TCAGAGGGGG CTCTGTAAGA CCCAGGGGAG TCAGGTGCAC TGGAGCGCGG 601 GCTGCAGAAA ACAGCCTGAG CTCCACCTCG GCTTCTCCTT GCCCTGGCTG GTTGTCCTTA 661 ACCCCTGTCT CCTTCTGGAC CAGTTTTTGT CCTTCCCTTG TGACCTGAGG GGTAACAGCC 721 TCTTTTCCAC TTTCTTTCAG CGCCGACATG CTCAATGTCA CCTTGCAAGG GCCCACTCTT 781 AACGGGACCT TTGCCCAGAG CAAATGCCCC CAAGTGGAGT GGCTGGGCTG GCTCAACACC 841 ATCCAGCCCC CCTTCCTCTG GGTGCTGTTC GTGCTGGCCA CCCTAGAGAA CATCTTTGTC 901 CTCAGCGTCT TCTGCCTGCA CAAGAGCAGC TGCACGGTGG CAGAGATCTA CCTGGGGAAC 961 CTGGCCGCAG CAGACCTGAT CCTGGCCTGC GGGCTGCCCT TCTGGGCCAT CACCATCTCC 1021 AACAACTTCG ACTGGCTCTT TGGGGAGACG CTCTGCCGCG TGGTGAATGC CATTATCTCC 1081 ATGAACCTGT ACAGCAGCAT CTGTTTCCTG ATGCTGGTGA GCATCGACCG CTACCTGGCC 1141 CTGGTGAAAA CCATGTCCAT GGGCCGGATG CGCGGCGTGC GCTGGGCCAA GCTCTACAGC 1201 TTGGTGATCT GGGGGTGTAC GCTGCTCCTG AGCTCACCCA TGCTGGTGTT CCGGACCATG 1261 AAGGAGTACA GCGATGAGGG CCACAACGTC ACCGCTTGTG TCATCAGCTA CCCATCCCTC 1321 ATCTGGGAAG TGTTCACCAA CATGCTCCTG AATGTCGTGG GCTTCCTGCT GCCCCTGAGT 1381 GTCATCACCT TCTGCACGAT GCAGATCATG CAGGTGCTGC GGAACAACGA GATGCAGAAG 1441 TTCAAGGAGA TCCAGACGGA GAGGAGGGCC ACGGTGCTAG TCCTGGTTGT GCTGCTGCTA 1501 TTCATCATCT GCTGGCTGCC CTTCCAGATC AGCACCTTCC TGGATACGCT GCATCGCCTC 1561 GGCATCCTCT CCAGCTGCCA GGACGAGCGC ATCATCGATG TAATCACACA GATCGCCTCC 1621 TTCATGGCCT ACAGCAACAG CTGCCTCAAC CCACTGGTGT ACGTGATCGT GGGCAAGCGC 1681 TTCCGAAAGA AGTCTTGGGA GGTGTACCAG GGAGTGTGCC AGAAAGGGGG CTGCAGGTCA 1741 GAACCCATTC AGATGGAGAA CTCCATGGGC ACACTGCGGA CCTCCATCTC CGTGGAACGC 1801 CAGATTCACA AACTGCAGGA CTGGGCAGGG AGCAGACAGT GAGCAAACGC CAGCAGGGCT 1861 GCTGTGAATT TGTGTAAGGA TTGAGGGACA GTTGCTTTTC AGCATGGGCC CAGGAATGCC 1921 AAGGAGACAT CTATGCACGA CCTTGGGAAA TGAGTGTTGA TGTCTCCGGT AAAACACCGG 1981 AGACTAATTC CTGCCCTGCC CAATTTTCGA GGGAGCATGG CTGTGAGGAT GGGGTGAACT 2041 CACGCACAGC CAAGGACTCC AAAATCACAA CAGCATTACT GTTCTTATTT GCTGCCACAC 2101 CTGAGCCAGC CTGCTCCTTC CCAGGAGTGG AGGAGGCCTG GGGGAGGGAG AGGAGTGACT 2161 GAGCTTCCCT CCCGTGTGTT CTCCGTCCCT GCCCCAGCAA GACAACTTAG ATCTCCAGGA 2221 GAACTGCCAT CCACGTTTGG TGCAATGGCT GAGTGCACAA GTGAGTTGTT GCCCTGGGTT 2281 TCTTTAATCT ATCAGCTAGA ACTTTGAAGG ACAATTTCTT GCATTAATAA AGGTTAAGCC 2341 CTGAGGGGTC CCTTGATAAC AACCTGGAGA CCAGGATTTT ATGGCTCCCC TCACTGATGG 2401 ACAAGGAGGT CTGTGCCAAA GAAGAATCAA TAAGCACATA TGAGCACTTC TGTATATCAG 2461 TATTGAGCAC TGTAGGCA (2) INFORMATION FOR SEQ ID NO:2448: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1201 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2448: 1 ATGTTCTCTC CCTGGAAGAT ATCAATGTTT CTGTCTGTTT GTGAGGACTC CGTGCCCACC 61 ACGGCCTCTT TCAGCGCCGA CATGCTCAAT GTCACCTTGC AAGGGCCCAC TCTTAACGGG 121 ACCTTTGCCC AGAGCAAATG CCCCCAAGTG GAGTGGCTGG GCTGGCTCAA CACCATCCAG 181 CCCCCCTTCC TCTGGGTGCT GTTCGTGCTG GCCACCCTAG AGAACATCTT TGTCCTCAGC 241 GTCTTCTGCC TGCACAAGAG CAGCTGCACG GTGGCAGAGA TCTACCTGGG GAACCTGGCC 301 GCAGCAGACC TGATCCTGGC CTGCGGGCTG CCCTTCTGGG CCATCACCAT CTCCAACAAC 361 TTCGACTGGC TCTTTGGGGA GACGCTCTGC CGCGTGGTGA ATGCCATTAT CTCCATGAAC 421 CTGTACAGCA GCATCTGTTT CCTGATGCTG GTGAGCATCG ACCGCTACCT GGCCCTGGTG 481 AAAACCATGT CCATGGGCCG GATGCGCGGC GTGCGCTGGG CCAAGCTCTA CAGCTTGGTG 541 ATCTGGGGGT GTACGCTGCT CCTGAGCTCA CCCATGCTGG TGTTCCGGAC CATGAAGGAG 601 TACAGCGATG AGGGCCACAA CGTCACCGCT TGTGTCATCA GCTACCCATC CCTCATCTGG 661 GAAGTGTTCA CCAACATGCT CCTGAATGTC GTGGGCTTCC TGCTGCCCCT GAGTGTCATC 721 ACCTTCTGCA CGATGCAGAT CATGCAGGTG CTGCGGAACA ACGAGATGCA GAAGTTCAAG 781 GAGATCCAGA CGGAGAGGAG GGCCACGGTG CTAGTCCTGG TTGTGCTGCT GCTATTCATC 841 ATCTGCTGGC TGCCCTTCCA GATCAGCACC TTCCTGGATA CGCTGCATCG CCTCGGCATC 901 CTCTCCAGCT GCCAGGACGA GCGCATCATC GATGTAATCA CACAGATCGC CTCCTTCATG 961 GCCTACAGCA ACAGCTGCCT CAACCCACTG GTGTACGTGA TCGTGGGCAA GCGCTTCCGA 1021 AAGAAGTCTT GGGAGGTGTA CCAGGGAGTG TGCCAGAAAG GGGGCTGCAG GTCAGAACCC 1081 ATTCAGATGG AGAACTCCAT GGGCACACTG CGGACCTCCA TCTCCGTGGA ACGCCAGATT 1141 CACAAACTGC AGGACTGGGC AGGGAGCAGA CAGTGAGCAA ACGCCAGCAG GGCTGCTGTG 1201 AATTTGTGTA AGGATTGAGG GACAGTTGCT T WO 00/09525 PCT/US99/17712 EPI-109 593 (2) INFORMATION FOR SEQ ID NO:2449: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1201 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2449: 1 ATGTTCTCTC CCTGGAAGAT ATCAATGTTT CTGTCTGTTC GTGAGGACTC CGTGCCCACC 61 ACGGCCTCTT TCAGCGCCGA CATGCTCAAT GTCACCTTGC AAGGGCCCAC TCTTAACGGG 121 ACCTTTGCCC AGAGCAAATG CCCCCAAGTG GAGTGGCTGG GCTGGCTCAA CACCATCCAG 181 CCCCCCTTCC TCTGGGTGCT GTTCGTGCTG GCCACCCTAG AGAACATCTT TGTCCTCAGC 241 GTCTTCTGCC TGCACAAGAG CAGCTGCACG GTGGCAGAGA TCTACCTGGG GAACCTGGCC 301 GCAGCAGACC TGATCCTGGC CTGCGGGCTG CCCTTCTGGG CCATCACCAT CTCCAACAAC 361 TTCGACTGGC TCTTTGGGGA GACGCTCTGC CGCGTGGTGA ATGCCATTAT CTCCATGAAC 421 CTGTACAGCA GCATCTGTTT CCTGATGCTG GTGAGCATCG ACCGCTACCT GGCCCTGGTG 481 AAAACCATGT CCATGGGCCG GATGCGCGGC GTGCGCTGGG CCAAGCTCTA CAGCTTGGTG 541 ATCTGGGGGT GTACGCTGCT CCTGAGCTCA CCCATGCTGG TGTTCCGGAC CATGAAGGAG 601 TACAGCGATG AGGGCCACAA CGTCACCGCT TGTGTCATCA GCTACCCATC CCTCATCTGG 661 GAAGTGTTCA CCAACATGCT CCTGAATGTC GTGGGCTTCC TGCTGCCCCT GAGTGTCATC 721 ACCTTCTGCA CGATGCAGAT CATGCAGGTG CTGCGGAACA ACGAGATGCA GAAGTTCAAG 781 GAGATCCAGA CGGAGAGGAG GGCCACGGTG CTAGTCCTGG TTGTGCTGCT GCTATTCATC 841 ATCTGCTGGC TGCCCTTCCA GATCAGCACC TTCCTGGATA CGCTGCATCG CCTCGGCATC 901 CTCTCCAGCT GCCAGGACGA GCGCATCATC GATGTAATCA CACAGATCGC CTCCTTCATG 961 GCCTACAGCA ACAGCTGCCT CAACCCACTG GTGTACGTGA TCGTGGGCAA GCGCTTCCGA 1021 AAGAAGTCTT GGGAGGTGTA CCAGGGAGTG TGCCAGAAAG GGGGCTGCAG GTCAGAACCC 1081 ATTCAGATGG AGAACTCCAT GGGCACACTG CGGACCTCCA TCTCCGTGGA ACGCCAGATT 1141 CACAAACTGC AGGACTGGGC AGGGAGCAGA CAGTGAGCAA ACGCCAGCAG GGCTGCTGTG 1201 AATTTGTGTA AGGATTGAGG GACAGTTGCT T (2) INFORMATION FOR SEQ ID NO:2450: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 241 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2450: 1 GCCCTTCAAA GATGAGCTGT TCCCGCCGCC ACTCCAGCTC TGGCTTCTGG GCTCCGAGGA 61 GGGGTGGGGA CGGTGGGGAC ATCAGGCTGC CCCGCAGTAC CAGGGAGCGA CTGAAGTGCC 121 CATGCCGCTT GCTCCGGAGA AGGTGGGTGC CGGGCAGGGG CTGCTCCAGC CGCCTCACCT 181 CTGCTGGGAG GACAAACTGT CCCAGCACAG AGGGAGGGAG GGAGGGCAGG CAGCGGGGAG 241 AAGTTTCCCT GTGGTCGTGG GGAGTT (2) INFORMATION FOR SEQ ID NO:2451: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 241 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2451: 1 GCCCTTCAAA GATGAGCTGT TCCCGCCGCC ACTCCAGCTC TGGCTTCTGG GCTCCGAGGA 61 GGGGTGGGGA CGGTGGTGAC GGTGGGGACA TCAGGCTGCC CCGCAGTACC AGGGAGCGAC 121 TGAAGTGCCC ATGCCGCTTG CTCCGGAGAA GGTGGGTGCC GGGCAGGGGC TGCTCCAGCC 181 GCCTCACCTC TGCTGGGAGG ACAAACTGTC CCAGCACAGA GGGAGGGAGG GAGGGCAGGC 241 AGCGGGGAGA AGTTTCCCTG TGGTCGTGGG GAGTT (2) INFORMATION FOR SEQ ID NO:2452: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1441 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2452: 1 GAGCTCTTCA ATATTTTAGT GAAAGCTATA GATGAGGCTC CATAGGGGAT AAAGCACAGA 61 CACACCTTTT CAGAGGGCTT GTGGACTCTG GGCAGCCTGT CCATAGACCT CTGTCCCCAA 121 CTGGCAAGTC AGGAAACTCC AGATTAAGGA GCCCCAATGT GGTTGAACAG CCAGGTGCAC 181 AGATGAGTCA ACCACACAGC CAGGCCAGGG AGGGCCTTCA CTCAAGAGCC TACAGCCAGT 241 TCACAGCCAA GCCAGGGCTA GCGCCAGGCC ACCCATAAAC TGATCTGAGA CTCTGTTTCC 301 CTGTCTCCAT GATGATGGGA TCAGGCTTGA TTGCTGGTTT GTAGGCTTGT TATGAATCAA 361 GTCACAGGGA AGAGGAGCTG ATGGGCTGGG GGGACGTCCT CTGGCCCTCC TGTCTCTTCC WO 00/09525 PCT/US99/17712 EPI-109 594 421 CCAGATCCAC TGGGCCCACT CTTATCTGTT CTCTTCTGAA GGAAGGGTTT TAAGGCTTCA 481 AAAAAAAATG TTTTGAAAGT CCCTGCCCTT TCCAGCTCCT ACCGTCTCAG CCCTGGGAGT 541 GTAAAGTGCT GCAGATAGTT AGTAAGTCTT TGAGCAAAAC TGAGAAAGCC AGCCTGAGCC 601 TTGACATGGG AGAAACCTCC GCCATACATC TCCGAAGAAA CGGCCGCGTG TCTCAGGGGA 661 GCGCAAACAC CCGTACCCAG GAAACAGGAC AGCTTCTGCC ACTGTCGCCC TTGGGAGCCG 721 TACGTGGCAT GACAAAGAAA TCCCAGGACT CCGCCTGCCC ACCTGGCCAC CCTCTGTTTA 781 CACCTTCCGC GTAAACGCCC ACTGTTTACA TCCAAAACTC AGACACAAAA TAACCACCTC 841 AAGAAGATAA ATAATGATAA GAAATAAATG TTACGCGAGG CAAATTTATT CACATGGGGC 901 TTCCCAGGCC ACTTTGTGGT CAGCCGGGAG GGACGTTTTT GCCGTCCCAC GACTCCAACG 961 GGCAGCCGGG CCTACGCAAA CATGGAAATC TTCCAAGAGC CTCCCTGGCC CCCAGGGCTC 1021 AGAGGGTGGC AGAGCGGAGA GCGAAGGTGG CCGCAGCCTT CCCGGCCCCA CAGCCAGCCT 1081 GGCTCCAGCT GGGCAGGAGT GCAGAGCTCA GCTGGAGGCG AGGGGGAAGT GCCCAGGAGG 1141 CTGATGACAT CACTACCCAG CCCTTCAAAG ATGAGCTGTT CCCGCCGCCA CTCCAGCTCT 1201 GGCTTCTGGG CTCCGAGGAG GGGTGGGGAC GGTGGTGACG GTGGGGACAT CAGGCTGCCC 1261 CGCAGTACCA GGGAGCGACT GAAGTGCCCA TGCCGCTTGC TCCGGAGAAG GTGGGTGCCG 1321 GGCAGGGGCT GCTCCAGCCG CCTCACCTCT GCTGGGAGGA CAAACTGTCC CAGCACAGAG 1381 GGAGGGAGGG AGGGCAGGCA GCGGGGAGAA GTTTCCCTGT GGTCGTGGGG AGTTGGGAAA 1441 AGTTCCCTTC CTTCCGGAGG GAGG (2) INFORMATION FOR SEQ ID NO:2453: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 2581 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2453: 1 CAGATTCACA AACTGCAGGA CTGGGCAGGG AGCAGACAGT GAGCAAACGC CAGCAGGGCT 61 GCTGTGAATT TGTGTAAGGA TTGAGGGACA GTTGCTTTTC AGCATGGGCC CAGGAATGCC 121 AAGGAGACAT CTATGCACGA CCTTGGGAAA TGAGTTGATG TCTCCGGTAA AACACCGGAG 181 ACTAATTCCT GCCCTGCCCA ATTTTGCAGG GAGCATGGCT GTGAGGATGG GGTGAACTCA 241 CGCACAGCCA AGGACTCCAA AATCACAACA GCATTACTGT TCTTATTTGC TGCCACACCT 301 GAGCCAGCCT GCTCCTTCCC AGGAGTGGAG GAGGCCTGGG GGGAGGGAGA GGAGTGACTG 361 AGCTTCCCTC CCGTGTGTTC TCCGTCCCTG CCCCAGCAAG ACAACTTAGA TCTCCAGGAG 421 AACTGCCATC CAGCTTTGGT GCAATGGCTG AGTGCACAAG TGAGTTGTTG CCCTGGGTTT 481 CTTTAATCTA TTCAGCTAGA ACTTTGAAGG ACAATTTCTT GCATTAATAA AGGTTAAGCC 541 CTGAGGGGTC CCTGATAACA ACCTGGAGAC CAGGATTTTA TGGCTCCCCT CACTGATGGA 601 CAAGGAGGTC TGTGCCAAAG AAGAATCCAA TAAGCACATA TTGAGCACTT GCTGTATATG 661 CAGTATTGAG CACTGTAGGC AAGACCCAAG AAAGAGAAGG AGCCATCTCC ATCTTGAAGG 721 AACTCAAAGA CTCAAGTGGG AACGACTGGG CACTGCCACC ACCAGAAAGC TGTTCGACGA 781 GACGGTCGAG CAGGGTGCTG TGGGTGATAT GGACAGCAGA AGGGGGAGAC CAAGGTTCCA 841 GCTCAACCAA TAACTATTGC ACAACCACCT GTCCCTGCCT CAGTTCCCTT TTATGTAACA 901 TGAAGTCGTT GTGAGGGTTA AAGGCAGTAA CAGGTATAAA GTACTTAGAA AAGCAAAGGG 961 TGCTACGTAC ATGTGAGGCA TCATTACGCA GACGTAACTG GGATATGTTT ACTATAAGGA 1021 AAAGACACTG AGGTCTAGAA ATAGCTCCGT GGAGCAGAAT CAGTATTGGG AGCCGGTGGC 1081 GGTGTGAAGC ACCAGTGTCT GGCACACAGT AGGTGCTCAT TGGCTCCCTT CCACCTGTCA 1141 TTCCCACCAC CCTGAGGCCC CAACCGCCAC ACACACAGGA GCATTTGGAG AGAAGGCCAT 1201 GTCTTCAAAG TCTGATTTGT GATGAGGCAG AGGAAGATAT TTCTAATCGG TCTTGCCCAG 1261 AGGATCACAG TGCTGAGACC CCCCACCACC AGCCGGTACC TGGGAAGGGG GAGAGTGCAG 1321 GCCTGCTCAG GGACTGTTCC TGTCTCAGCA ACCAAGGGAT TGTTCCTGTC AATCAATGGT 1381 TTATTGGAAG GTGGCCCAGT ATGAGCCCTA GAAGAGTGTG AAAAGGAATG GCAATGGTGT 1441 TCACCATCGG CAGTGCCAGG GCAGCACTCA TTCACTTGAT AAATGAATAT TTATTAGCTG 1501 GTTGGAGAGC TAGAACCTGG AGAGCTAGAA CCTGGAGAAC TAGAACCTGG AGGGCTAGAA 1561 CCTGGAGAGG CTAGAACCAA GAAGGGCTAG AACCTGGAGG GGCTAGAACC TAGAGAAGCT 1621 AAAACCTGAG CTAGAAGCTG GAGGACTAGA ACCTGGAGGG CTGGAATCTG AAGGGCTAGA 1681 ACCTGGAGGG CTGGAATCTG GAGAGCTAGA ACCTGGAGGG CTAGAACCTG GAGGGCTAGA 1741 ACCTAGAAGG GCTAGAACCT GGAGGGCTGG AATCTGGAGA GCTAGAACCT GGAGGGCTAG 1801 AACCTGGAGG GCTAGAACCT AGAAGGGCTA GAACCTGGAG GGCTAGAACC TGGCAGGTTA 1861 GAACCTAGAA GGGCTAGAAC CTGGAGAGCC AGAACCTGGA GGGCTAGAAC CTGGAAGGGC 1921 TAGAACCTGT AGAGCTAGAA CATGGAGAGC TAGAACCCGG CAGGCTAGAA CCTGGCAAGC 1981 TAGAACCTGG AGGGAATGAA CCTGGAGGGC TAGAACCTGG AGAATGAGAA AAATTTACAT 2041 GGCAAAGAGC CCATAAATCC TGACCAATCC AACTCTGAAT TTTAAAGCAA AAGCGTGAAA 2101 AAAAAGATTC CCTCCTTACC CCCAACCCAC TCTTTTTTCC CACCACCCAC TCTCCTCTGC 2161 CTCAGTAAGT ATCTGGAGGA AGAAAACAGG TGAAAGAAGA AGTAAAAACC ATTTAGTATT 2221 AGTATTAGAA TGAAGTCAAA CTGTGCCACA CATGGTGAAT GAAAAAAAAA AAAAAGAGGC 2281 TGTGTTTTGT CACACAGGGC AGTCATTCAG CACCAGAGCA CGTGATGGTC TGAGACTCTC 2341 TTAGGAGCAG AGCTCTGCCG CAATGGCCAT GTGGGGATCC ACACCTGGTC TGAGGGGCAA 2401 CTGAGTCTGC GGGAGAAGAG CGGCCCTATG CATGGTGTAG ATGCCCTGAT AAAGAACATC 2461 TGTCCTGTGA AAGACTCAAT GAGCTGTTAT GTTGTAAACA GGAAGCATTT CACATCCAAA 2521 CGAGAAAATC ATGTAAACAT GTGTCTTTTC TGTAGAGCAT AATAAATGGA TGAGGTTTTT WO 00/09525 PCT/US99/17712 EPI-109 595 2581 GCAAAAAAAA AAAAAAAAA (2) INFORMATION FOR SEQ ID NO:2454: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 7321 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2454: 1 AAATGATAGA CCGTCAATAA TTTGTTAAAT GCTTTTTAAA ATGAATGCTT TAAGCCGGGT 61 GCAGTGCCTC ACATCTGTAA TCCCAGCACT TTGGAGCCGA GCGGGTGGAT TGTGTGAGGT 121 CAGGAGTTCG AGACCAACCT GGCCAACATG GCAAAACCTC ACTCTCTACC AAAAATACAA 181 AAATTAGCCA GGCATGGTGG CAGGCACCTG TGATCCCAGC TACTCAGGAG GCTGAGACAG 241 GAGAATCGCT TGAACCCGGG AGGCAAGGTT GCAGTGAGCC AAGATTACGC CATTGTACTC 301 CAGCCTGGGT GACAGAGAGA GACTCCGTCT CAAAAAAAAA AAAAAAAAAA AAAAAATTAC 361 GCTTCAAACA CATGATCTCT CACCACTGTT GAATTTTCTT TCTATGAGCC CAGGAGGGCC 421 TCTCAGAGAG GAAAGCTCCT AGGTCTTCCT TTCCCTCTGC AAACTCCCTG CCTTGAAGGT 481 TCAGAAGGAC TGTGCGTGCT CGTTGCATCC TTTGCAAGTG TCCAAACCCT GATCCCAGCT 541 GTGCTTAGGG GTTCCTGCAA ACCTTTTCCA GGTGTTAATT ACCTCCCACT TCATTTCCTG 601 TTTACCAACT CAGCTTTTTG TTTTAGTGTG TTTGAATTCC CTGAACTGAC CGTTGTCTGA 661 TCTCCACCTC CCAACTGAAT TAGGGGAGCT GGGCTTCTGG AAACCCAGGT GCCGGGTGTT 721 GCAGAGTGGC TGAAAGCTGG GATGTGGCAG ATCCGTGGCT ACATTCATGC ACACACACAC 781 ACCCACATAC CCACACATGC ACACACACAC ACACACCCGC ACTCACACAC TTGGACATGC 841 ATAGACCACA GCTTTCCACA CCCTTCCTAG ACAGGGGTCA CTTGGTATCC TGGAGAGAGT 901 GTGAAGTCCT GGAATGGAAA GAGGGGGGAT TAAGCCCCAC CTCTAGCCAT GGGACTGAGA 961 CAAGTCACCA CCAACCCATC TGCGCCTTGT TTACCTCCTC TGTGAGGCAA GCACAGAGCC 1021 CATGCCTGCC CCCCTGGATG GGAGTGATGT GAAACTTGAA GGGCGGTCAG AGCAAGGGTC 1081 GGGAATGGAA GGCCCTTGGG AAAAAAGGCC CTTTCAACTA GGGGCACAGA GGAGGCCCTG 1141 GGCTGAGAAC TTGACAGCAC CTTGTAATTG GTAAGCCAAG CCCGAAGGGA CTGGAAATAC 1201 TCAGATGTGT CTGTCTCCCT TATTAGGTTC AAAGTCCCTC AAGACCCTGT CTCCATCACA 1261 GTGCTCCAGT CCAGACCCCT CCTCTGAGCT CCAGACCCTG CTGGACCCAA CCAGCCCTAT 1321 GGGGTCGCAT CCCCACCTGC CTGGAATTCT CCAAAGAACC TCCCCTTTAA CAGTTCCAGC 1381 CTTTAACAGT TCCAGTCTAA ACACATGACC TTTCTCCTCT AAATCAGCCC CCCATCTCTG 1441 CCTTTGCAGG AGATGGAAGC CATGACACCT GCCTCGCCCC TGTCCTCACC CCATCCATGT 1501 CCAATCAAGC ACTAGGCATG TCAGGTTTAC CCTCTAAACT CCTCTGGAAT CCAGTCTCTC 1561 AGTCTCCATC ATCCCAGGTC GAAGCTAATG GGCTAACTGG TCCTTGCTTC CACTCTACCC 1621 CCACTGCAGT CCTGACTTCC TGAGCAGCAG CCAGGGCCTA ATCGATATTC ACACCAAGCG 1681 CCAACCTGAC TGAGATATCC TCCTGCACCA TCATCCCTCC ACCCTGTTTA GTTCTGCTCA 1741 CCCTCAGTGT TCTCATCAAT AATCCACTCC CCTCACAGGC GCGTTTGGGA CCCCATGTTC 1801 TATGCTCTCA CAGGACCTTT TGCTTGATTT TTCACTGTAC TTAGGTCAGT TTGCAGTTAT 1861 TAAGTGACTG AGCAATGTCT GGCTTCTCCA GTAGACTGTC AGCTCCTAGC CATTGTATAC 1921 CTAGCACCGC TGTGTGGGAG CACGTGACAA ACGTCCAGTG AGTCAGGGAC TCAGCAGTCT 1981 CCATTTCTCC GCCCTGCTGG AGAATGCGTG TATTTGGCAA TCCCCAGCCC CTGTGCCATC 2041 TAACCATCTT TTCTTCTCTG TTCAGCCCAG GTGTGGCCTC ACTCACATCC CACTCTGAGT 2101 CCAAATGTTC TCTCCCTGGA AGATATCAAT GTTTCTGTCT GTTCGTGAGG ACTCCGTGCC 2161 CACCACGGCC TCTTTCAGGT GAGTCAAAGG GATTCCTCAG TTCACTAGTT AGGGGAGGTG 2221 GGCAGACACC CTGGAGAACT CCCTGGAAAG CTCAACTCTC ATGCCCCGGA CAACAGTTGA 2281 AGGAACCATG GTGATGTTAA GCCCAAAGAC AAAACCTCTC AGGTGTCCAA GTCCCTGTTG 2341 GAATCTTGGG AGCAGAGGGA ATGTTCTGTG GTCTAGAGGA AGAGGGGCTC AGGGAGGAGA 2401 AGGGCACATT CCTGGTTGTT ATATGTTTCT ATCTATCCCA GATGAACTTG GAAGTGAAGG 2461 GAAGAGAGTT AAACATTAAA GTAAATACCC AGTGGATCAG ACAGCAATGT GCCAGATTGC 2521 CTTGGAAACA AAATATCTCC AACACATGGC TGACATTTGG TGGGAGATCA GAACACCCTA 2581 AAGAGAGAAT TTAAGGGGAG GGGGAGGAGG ACCTGAGCCA GAGTAGAAGC AGAGGATAGG 2641 GAGATCTGTT CTTGGGGACA GCATTTGCAA GAAACAAGGC TGAGGGGTCC ACTCCAACCT 2701 CTCCACCCTG CTGCAGGTGC TGCCTATGAT GAAGATGAGC AGATGGCCAT CTCAGCTGGG 2761 GCCACAGTGC ACTGGACCTA TAGTTTCCAA TTCCGCACTC AGCAGGCATC TTTCTGATGA 2821 TCCGATGGCT TCTCAGAGCC AGGGATGGGC CAGGATCCAT CCCCTTGGCT ACTGTCTTGC 2881 TGAGAAATTT ATAAGCAGCA TCTGGTGCTA TACTTTGGTC TCTAGTGAGT TAGCTCATGA 2941 AAGATGATAG ACTCTCCAAG CCAGGGGTAT GCAGGAAATG GGTTTTCTGT AGCTACAGAA 3001 ATGGGGTTGA GGGTTGGACC AAGGGACTAC CCAGGGGAAG TCTTACCTTC AGAGGACTCT 3061 GGAAAGGAGG CTGCAAGTTT TCATGGGTCA AGAATTCAGA GCCCAGTAGA GACAGCTTAT 3121 CTCTGTTCCA AGATGTCTGG GGCCTTGGTT GGAAGATTCA AAGGCTAGGA AACCAGGAGC 3181 CACCAAAAGC GTAACTGGGG CCAGAGGATC CACTTTCAAG GTGGCAAGTT GGTTCCCCCC 3241 ATGTGGCTGC TTGAGTATCC TCACATGGCG GCTCACATCC TTCCAAGTAA GCAATGCAAA 3301 AGGCCAAGAA AGATGCTGCA AAGATGTTAT GACCTAGCCT CAGAAATCAC ACACCATCCC 3361 TGCCACCATT AGTAAGAAGT CCAGCCCACG TCCAGGAGAA GAGGAAGCAG ATTCCTCCTT 3421 TTGAAATGAA GAATATCAAG TAATTCGGGG GGCATATGAA AGCCACCACA CACCACAGGG 3481 ATCTTTTTAG AGCATACTTC TTATACCATC ACTGTAGTTC CTTAAGACTC AGGGGCAAAG 3541 CCTCACTTCC TTAGCACCCA GTGAAGACCA CGCTTACTCC CTCACTCAAC CTCTTGCTAC WO 00/09525 PCT/US99/17712 EPI-109 596 3601 TTCCCACCTC TCCTGTCCAA CATCTAGTGT CACTTTCCAG AACATACCAA CAGCTTCCCC 3661 AGTTCTGTGC CTCTGCTCAG GCTGTTCCCC CTGCCTGGTC CACTTGTCCT CCTTCTTGTC 3721 CGGTCAAAAT GCTTCTTATC CTTCAAGACC CAGCTCTAGA GTCACCTCCA ACCCCTTACC 3781 CACCAGCCCC CTCTCCAAGT CTGTGTCCCA CAACCCCCCT GCTCCCTCCA GGGCACCCTC 3841 CACCCTCTGG GCCACAGTTG TCAGGAGTCA GGCAGGGCAG GGGCCGGGTG GTGTCTTCTT 3901 TGTGTTCTTG CACTCAGGGC AGAGCTCAGC ACAGAGCAGA CGCTCAAAAA ACATTTAAAG 3961 GATAGAAGCA TTGATTTGTG GGTCCCCCAG TCTGGCTCCA GGATGCCAGC CAGCTGCTCC 4021 TAGAAGCAAA CGGACTTTTC CTGGGAAATC CCAGAGGTGA TGATCAGTAA TCTCTCCCGT 4081 GACTCGTAGT TCAGCTCTTC CTCCATGAGC CTGACTATCA GTGGACCTTC CAGAAAGAGC 4141 CCCTTTTCCT TCTCTCACCC ACAGCACAGG GCACTGGGAA AATGCCCAAT GAGTCCTGCC 4201 TCTGGGTTGT GCTTTGGACT TTTCAGTGTG TCTCGCATCC ACTCTTCAAC TTGAATGTTG 4261 CAACAGCCAT GAAAAAAGAA ATGCAAAGCG ATTCAGGATG AGAGCAATAC CCTACTCCAA 4321 AGAAGGCAAC ATAGAAGCTC AGAGAGATCA AGCAATTTGC CCAAGACCAC ACAGCTAGGA 4381 GTGGAACTCA TGGCTGTCCA AGCCCCATGC CTCTGCTGAA GGTAGAGATG AATTACAGCA 4441 ACAAGTCTAG AAAGGTGCCT GCCCTATGGT CTGTGAGTCT TGCCTAAGAA TGAAAGAGGA 4501 GCCAGTGGGT TAAAGATGAG GTCACCAACA ACGGTGGTGT TGGAGTTTAC CACTGATAAT 4561 AAGGGTGCAA AATGTAAATT ACTAATGTTT ATTGAGCCTA GTGCAGTGCG TGGGGCATTT 4621 TGCACATTGT CTCTGATCCC TATGACAACC CTGAGAGGTA GTGGTTTTAA CTGCCATGTT 4681 ACAGGTGAGG TCATTGTGGT TCAAGGACGT TAAGTAACTT CCCCAGCGTG ACACGGCTTA 4741 TAAGTAAGGC AGCCAGGATG TGAACCCAGT AGGACTATCT GGCTGCAAAG TCCCCACCCC 4801 CCTCGCCATC TGTATCCTCC AATCACTTCA GTGCTTTGCT GCATAGAAGG TAACGGAAAT 4861 CACGATGCCA CAGACTGTCC AGGAAGACAG AAACTAGGCA GATGGGCTGG CCATGGTCTC 4921 CAAGCCAGAC TGGAATCTCC AGGTCTGGAA TGATATCATT TTTCTCTTTT AATAAATTAA 4981 CTCACCCACC ACACGGCTTT GAGAGGCTCA AAGTTGACCA ACTCCCTTGG GAGGGCCCCG 5041 GTTGATAAGG AAGGAACGTG AATCCTCCCA TCACGGAAGC TTCAAGGAGG TCAAGGGTCC 5101 AACACTTGAG ATTGTTAGTG CTGTTGGTGG ATACTGGCCA AGGAAATATC CCAGTGGAGC 5161 CTCGAGATGA AGAACATGAG GCCCCCGTTT AGAACCAAGG ATCAGAGGGG GCTCTGTAAG 5221 ACCCAGGGGA GTCAGGTGCA CTGGAGCGCG GGCATGCAGA AAACAGCCTG AGCTCCACCT 5281 CGGCTTCTCC TTGTCCTGGC TGGTTGTCCT TAACCCCTGT CTCCTTCTGG ACCAGTTTTT 5341 GTCCTTCCCT TGTGACCGCT GAGGGGTAAC AGCCTCTTTC CACTTTCTTT CAGCGCCGAC 5401 ATGCTCAATG TCACCTTGCA AGGGCCCACT CTTAACGGGA CCTTTGCCCA GAGCAAATGC 5461 CCCCAAGTGG AGTGGCTGGG CTGGCTCAAC ACCATCCAGC CCCCCTTCCT CTGGGTGCTG 5521 TTCGTGCTGG CCACCCTAGA GAACATCTTT GTCCTCAGCG TCTTCTGCCT GCACAAGAGC 5581 AGCTGCACGG TGGCAGAGAT CTACCTGGGG AACCTGGCCG CAGCAGACCT GATCCTGGCC 5641 TGCGGGCTGC CCTTCTGGGC CATCACCATC TCCAACAACT TCGACTGGCT CTTTGGGGAG 5701 ACGCTCTGCC GCGTGGTGAA TGCCATTATC TCCATGAACC TGTACAGCAG CATCTGTTTC 5761 CTGATGCTGG TGAGCATCGA CCGCTACCTG GCCCTGGTGA AAACCATGTC CATGGGCCGG 5821 ATGCGCGGCG TGCGCTGGGC CAAGCTCTAC AGCTTGGTGA TCTGGGGGTG TACGCTGCTC 5881 CTGAGCTCAC CCATGCTGGT GTTCCGGACC ATGAAGGAGT ACAGCGATGA GGGCCACAAC 5941 GTCACCGCTT GTGTCATCAG CTACCCATCC CTCATCTGGG AAGTGTTCAC CAACATGCTC 6001 CTGAATGTCG TGGGCTTCCT GCTGCCCCTG AGTGTCATCA CCTTCTGCAC GATGCAGATC 6061 ATGCAGGTGC TGCGGAACAA CGAGATGCAG AAGTTCAAGG AGATCCAGAC GGAGAGGAGG 6121 GCCACGGTGC TAGTCCTGGT TGTGCTGCTG CTATTCATCA TCTGCTGGCT GCCCTTCCAG 6181 ATCAGCACCT TCCTGGATAC GCTGCATCGC CTCGGCATCC TCTCCAGCTG CCAGGACGAG 6241 CGCATCATCG ATGTAATCAC ACAGATCGCC TCCTTCATGG CCTACAGCAA CAGCTGCCTC 6301 AACCCACTGG TGTACGTGAT CGTGGGCAAG CGCTTCCGAA AGAAGTCTTG GGAGGTGTAC 6361 CAGGGAGTGT GCCAGAAAGG GGGCTGCAGG TCAGAACCCA TTCAGATGGA GAACTCCATG 6421 GGCACACTGC GGACCTCCAT CTCCGTGGAA CGCCAGATTC ACAAACTGCA GGACTGGGCA 6481 GGGAGCAGAC AGTGAGCAAA CGCCAGCAGG GCTGCTGTGA ATTTGTGTAA GGATTGAGGG 6541 ACAGTTGCTT TTCAGCATGG GCCCAGGAAT GCCAAGGAGA CATCTATGCA CGACCTTGGG 6601 AAATGAGTTG ATGTCTCCGG TAAAACACCG GAGACTAATT CCTGCCCTGC CCAATTTTGC 6661 AGGGAGCATG GCTGTGAGGA TGGGGTGAAC TCACGCACAG CCAAGGACTC CAAAATCACA 6721 ACAGCATTAC TGTTCTTATT TGCTGCCACA CCTGAGCCAG CCTGCTCCTT CCCAGGAGTG 6781 GAGGAGGCCT GGGGGCAGGG AGAGGAGTGA CTGAGCTTCC CTCCCGTGTG TTCTCCGTCC 6841 CTGCCCCAGC AAGACAACTT AGATCTCCAG GAGAACTGCC ATCCAGCTTT GGTGCAATGG 6901 CTGAGTGCAC AAGTGAGTTG TTGCCCTGGG TTTCTTTAAT CTATTCAGCT AGAACTTTGA 6961 AGGACAATTT CTTGCATTAA TAAAGGTTAA GCCCTGAGGG GTCCCTGATA ACAACCTGGA 7021 GACCAGGATT TTATGGCTCC CCTCACTGAT GGACAAGGAG GTCTGTGCCA AAGAAGAATC 7081 CAATAAGCAC ATATTGAGCA CTTGCTGTAT ATGCAGTATT GAGCACTGTA GGCAAGAGGG 7141 AAGAAAGAGA AGGAGCCATC TCCATCTTGA AGGAACTCAA AGACTCAAGT GGGAACGACT 7201 GGGCACTGCC ACCACCAGAA AGCTGTTCGA TGAGACGGTC GAGCAGGGTG CTGTGGGTGA 7261 TATGGACAGC AGAAGGGGGA GCCAGGTTCC AGCTCACCAA TACTATTGCA CACCACCTGT 7321 CCTGCCTC (2) INFORMATION FOR SEQ ID NO:2455: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 2221 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single WO 00/09525 PCT/US99/17712 EPI-109 597 (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2455: 1 CTGCAGAAAA CAGCCTGAGC TCCACCTCGG CTTCTCCTTG CCCTGGCTGG TTGTCCTTAA 61 CCCCTGTCTC CTTCTGGACC AGTTTTTGTC CTTCCCTTGT GACCCTGAGG GGTAACAGCC 121 TCTTTTCCAC TTTCTTTCAG CGCCGACATG CTCAATGTCA CCTTGCAAGG GCCCACTCTT 181 AACGGGACCT TTGCCCAGAG CAAATGCCCC CAAGTGGAGT GGCTGGGCTG GCTCAACACC 241 ATCCAGCCCC CCTTCCTCTG GGTGCTGTTC GTGCTGGCCA CCCTAGAGAA CATCTTTGTC 301 CTCAGCGTCT TCTGCCTGCA CAAGAGCAGC TGCACGGTGG CAGAGATCTA CCTGGGGAAC 361 CTGGCCGCAG CAGACCTGAT CCTGGCCTGC GGGCTGCCCT TCTGGGCCAT CACCATCTCC 421 AACAACTTCG ACTGGCTCTT TGGGGAGACG CTCTGCCGCG TGGTGAATGC CATTATCTCC 481 ATGAACCTGT ACAGCAGCAT CTGTTTCCTG ATGCTGGTGA GCATCGACCG CTACCTGGCC 541 CTGGTGAAAA CCATGTCCAT GGGCCGGATG CGCGGCGTGC GCTGGGCCAA GCTCTACAGC 601 TTGGTGATCT GGGGGTGTAC GCTGCTCCTG AGCTCACCCA TGCTGGTGTT CCGGACCATG 661 AAGGAGTACA GCGATGAGGG CCACAACGTC ACCGCTTGTG TCATCAGCTA CCCATCCCTC 721 ATCTGGGAAG TGTTCACCAA CATGCTCCTG AATGTCGTGG GCTTCCTGCT GCCCCTGAGT 781 GTCATCACCT TCTGCACGAT GCAGATCATG CAGGTGCTGC GGAACAACGA GATGCAGAAG 841 TTCAAGGAGA TCCAGACGGA GAGGAGGGCC ACGGTGCTAG TCCTGGTTGT GCTGCTGCTA 901 TTCATCATCT GCTGGCTGCC CTTCCAGATC AGCACCTTCC TGGATACGCT GCATCGCCTC 961 GGCATCCTCT CCAGCTGCCA GGACGAGCGC ATCATCGATG TAATCACACA GATCGCCTCC 1021 TTCATGGCCT ACAGCAACAG CTGCCTCAAC CCACTGGTGT ACGTGATCGT GGGCAAGCGC 1081 TTCCGAAAGA AGTCTTGGGA GGTGTACCAG GGAGTGTGCC AGAAAGGGGG CTGCAGGTCA 1141 GAACCCATTC AGATGGAGAA CTCCATGGGC ACACTGCGGA CCTCCATCTC CGTGGAACGC 1201 CAGATTCACA AACTGCAGGA CTGGGCAGGG AGCAGACAGT GAGCAAACGC CAGCAGGGCT 1261 GCTGTGAATT TGTGTAAGGA TTGAGGGACA GTTGCTTTTC AGCATGGGCC CAGGAATGCC 1321 AAGGAGACAT CTATGCACGA CCTTGGGAAA TGAGTTGATG TCTCCGGTAA AACACCGGAG 1381 ACTAATTCCT GNCCTGCCCA ATTTTGCAGG GAGCATGGCT GTGAGGATGG GGTGAACTCA 1441 CGCACAGCCA AGGACTCCAA AATCACAACA GCATTACTGT TCTTATTTGC TGCCACACCT 1501 GAGCCAGCCT GCTCCTTCCC AGGAGTGGAG GAGGCCTGGG GGCAGGGAGA GGAGTGACTG 1561 AGCTTCCCTC CCGTGTGTTC TCCGTCCCTG CCCCAGCAAG ACAACTTAGA TCTCCAGGAG 1621 AACTGCCATC CAGCTTTGGT GCAATGGCTG AGTGCACAAG TGAGTTGTTG CCCTGGGTTT 1681 CTTTAATCTA TTCAGCTAGA ACTTTGAAGG ACAATTTCTT GCATTAATAA AGGTTAAGCC 1741 CTGAGGGGTC CCTGATAACA ACCTGGAGAC CAGGATTTTA TGGCTCCCCT CACTGATGGA 1801 CAAGGGAGGT CTGTGCCAAA GAAGAATCCA ATAAGCACAT ATTGAGCACT TGCTGTATAT 1861 GCAGTATTGA GCACTGTAGG CAAGAGGGAA GAAAGAGAAG GAGCCATCTC CATCTTGAAG 1921 GAACTCAAAG ACTCAAGTGG GAACGACTGG CACTGCCACC ACCAGAAAGC TGTTCGACGA 1981 GACGGTCGAG CAGGGTGCTG TGGGTGATAT GGACAGCAGA AGGGGGAGAC CAAGGTTCCA 2041 GCTCAACCAA TAACTATTGC ACAACCACCT GTCCCTGCCT CAGTTCCCTC TTCTGTAACA 2101 TGAAGTCGTT GTGAGGGTTA AAGGCAGTAA CAGGTATAAA GTACTTAGAA AAGCAAAGGG 2161 TGCTACGTAC ATGTGAGGCA TCATTACGCA GACGTAACTG GGATATGTTT ACTATAAGGA 2221 AAAGACACTG AGGTCTAGA (2) INFORMATION FOR SEQ ID NO:2456: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 2461 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2456: 1 TGATCCTATC ACAACCTGAG AGTAGTTTTT ACTCCATTTA CAGGTGAGGT CATTGTGGTT 61 CAAGGACGTT AAGTAACTTC CCCAGCTCAC ACGGCTTATA AGTAAGGCAG CCAGGATGTG 121 AACCCAGTAG GACTATCTGG CTGCAAAGTC CCCACCCTCC CTCGCCATCT GTATCCTCCA 181 ATCATCTTCA GTGCTTTGCT GATAGAAGGT ACGGAAATAC GATGCCACAG ACTGTCCAGG 241 AAGACAGAAA CTAGGCAGAT GGGCTGGCCA TGGTCTCCAA GCCAGACTGG AATCTCCAGG 301 TCTGGAATGA TATCATTTTT CTCTTTTAAT AAATTAACTC ACCCACCACA CGGCTTTGAG 361 AGGCTCAAAG GTGACCAACT CCCTTGGGAG GGCCCCGGTT GATAAGGAAG GAATGTGAAT 421 CCTCCCATCA CGGAAGCTTC AAGGAGGTCA AGGGTCCAAC ACTTGAGATT GTTAGTGCTG 481 TTGGTGGATA CTGCAGAATA TCCAGTGGAG CCTCAGATGA AGAACATGAG GCCCCGTTTA 541 GATCCAAGGA TCAGAGGGGG CTCTGTAAGA CCCAGGGGAG TCAGGTGCAC TGGAGCGCGG 601 GCTGCAGAAA ACAGCCTGAG CTCCACCTCG GCTTCTCCTT GCCCTGGCTG GTTGTCCTTA 661 ACCCCTGTCT CCTTCTGGAC CAGTTTTTGT CCTTCCCTTG TGACCTGAGG GGTAACAGCC 721 TCTTTTCCAC TTTCTTTCAG CGCCGACATG CTCAATGTCA CCTTGCAAGG GCCCACTCTT 781 AACGGGACCT TTGCCCAGAG CAAATGCCCC CAAGTGGAGT GGCTGGGCTG GCTCAACACC 841 ATCCAGCCCC CCTTCCTCTG GGTGCTGTTC GTGCTGGCCA CCCTAGAGAA CATCTTTGTC 901 CTCAGCGTCT TCTGCCTGCA CAAGAGCAGC TGCACGGTGG CAGAGATCTA CCTGGGGAAC 961 CTGGCCGCAG CAGACCTGAT CCTGGCCTGC GGGCTGCCCT TCTGGGCCAT CACCATCTCC 1021 AACAACTTCG ACTGGCTCTT TGGGGAGACG CTCTGCCGCG TGGTGAATGC CATTATCTCC 1081 ATGAACCTGT ACAGCAGCAT CTGTTTCCTG ATGCTGGTGA GCATCGACCG CTACCTGGCC 1141 CTGGTGAAAA CCATGTCCAT GGGCCGGATG CGCGGCGTGC GCTGGGCCAA GCTCTACAGC 1201 TTGGTGATCT GGGGGTGTAC GCTGCTCCTG AGCTCACCCA TGCTGGTGTT CCGGACCATG WO 00/09525 PCT/US99/17712 EPI-109 598 1261 AAGGAGTACA GCGATGAGGG CCACAACGTC ACCGCTTGTG TCATCAGCTA CCCATCCCTC 1321 ATCTGGGAAG TGTTCACCAA CATGCTCCTG AATGTCGTGG GCTTCCTGCT GCCCCTGAGT 1381 GTCATCACCT TCTGCACGAT GCAGATCATG CAGGTGCTGC GGAACAACGA GATGCAGAAG 1441 TTCAAGGAGA TCCAGACGGA GAGGAGGGCC ACGGTGCTAG TCCTGGTTGT GCTGCTGCTA 1501 TTCATCATCT GCTGGCTGCC CTTCCAGATC AGCACCTTCC TGGATACGCT GCATCGCCTC 1561 GGCATCCTCT CCAGCTGCCA GGACGAGCGC ATCATCGATG TAATCACACA GATCGCCTCC 1621 TTCATGGCCT ACAGCAACAG CTGCCTCAAC CCACTGGTGT ACGTGATCGT GGGCAAGCGC 1681 TTCCGAAAGA AGTCTTGGGA GGTGTACCAG GGAGTGTGCC AGAAAGGGGG CTGCAGGTCA 1741 GAACCCATTC AGATGGAGAA CTCCATGGGC ACACTGCGGA CCTCCATCTC CGTGGAACGC 1801 CAGATTCACA AACTGCAGGA CTGGGCAGGG AGCAGACAGT GAGCAAACGC CAGCAGGGCT 1861 GCTGTGAATT TGTGTAAGGA TTGAGGGACA GTTGCTTTTC AGCATGGGCC CAGGAATGCC 1921 AAGGAGACAT CTATGCACGA CCTTGGGAAA TGAGTGTTGA TGTCTCCGGT AAAACACCGG 1981 AGACTAATTC CTGCCCTGCC CAATTTTCGA GGGAGCATGG CTGTGAGGAT GGGGTGAACT 2041 CACGCACAGC CAAGGACTCC AAAATCACAA CAGCATTACT GTTCTTATTT GCTGCCACAC 2101 CTGAGCCAGC CTGCTCCTTC CCAGGAGTGG AGGAGGCCTG GGGGAGGGAG AGGAGTGACT 2161 GAGCTTCCCT CCCGTGTGTT CTCCGTCCCT GCCCCAGCAA GACAACTTAG ATCTCCAGGA 2221 GAACTGCCAT CCACGTTTGG TGCAATGGCT GAGTGCACAA GTGAGTTGTT GCCCTGGGTT 2281 TCTTTAATCT ATCAGCTAGA ACTTTGAAGG ACAATTTCTT GCATTAATAA AGGTTAAGCC 2341 CTGAGGGGTC CCTTGATAAC AACCTGGAGA CCAGGATTTT ATGGCTCCCC TCACTGATGG 2401 ACAAGGAGGT CTGTGCCAAA GAAGAATCAA TAAGCACATA TGAGCACTTC TGTATATCAG 2461 TATTGAGCAC TGTAGGCA (2) INFORMATION FOR SEQ ID NO:2457: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1201 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2457: 1 ATGTTCTCTC CCTGGAAGAT ATCAATGTTT CTGTCTGTTT GTGAGGACTC CGTGCCCACC 61 ACGGCCTCTT TCAGCGCCGA CATGCTCAAT GTCACCTTGC AAGGGCCCAC TCTTAACGGG 121 ACCTTTGCCC AGAGCAAATG CCCCCAAGTG GAGTGGCTGG GCTGGCTCAA CACCATCCAG 181 CCCCCCTTCC TCTGGGTGCT GTTCGTGCTG GCCACCCTAG AGAACATCTT TGTCCTCAGC 241 GTCTTCTGCC TGCACAAGAG CAGCTGCACG GTGGCAGAGA TCTACCTGGG GAACCTGGCC 301 GCAGCAGACC TGATCCTGGC CTGCGGGCTG CCCTTCTGGG CCATCACCAT CTCCAACAAC 361 TTCGACTGGC TCTTTGGGGA GACGCTCTGC CGCGTGGTGA ATGCCATTAT CTCCATGAAC 421 CTGTACAGCA GCATCTGTTT CCTGATGCTG GTGAGCATCG ACCGCTACCT GGCCCTGGTG 481 AAAACCATGT CCATGGGCCG GATGCGCGGC GTGCGCTGGG CCAAGCTCTA CAGCTTGGTG 541 ATCTGGGGGT GTACGCTGCT CCTGAGCTCA CCCATGCTGG TGTTCCGGAC CATGAAGGAG 601 TACAGCGATG AGGGCCACAA CGTCACCGCT TGTGTCATCA GCTACCCATC CCTCATCTGG 661 GAAGTGTTCA CCAACATGCT CCTGAATGTC GTGGGCTTCC TGCTGCCCCT GAGTGTCATC 721 ACCTTCTGCA CGATGCAGAT CATGCAGGTG CTGCGGAACA ACGAGATGCA GAAGTTCAAG 781 GAGATCCAGA CGGAGAGGAG GGCCACGGTG CTAGTCCTGG TTGTGCTGCT GCTATTCATC 841 ATCTGCTGGC TGCCCTTCCA GATCAGCACC TTCCTGGATA CGCTGCATCG CCTCGGCATC 901 CTCTCCAGCT GCCAGGACGA GCGCATCATC GATGTAATCA CACAGATCGC CTCCTTCATG 961 GCCTACAGCA ACAGCTGCCT CAACCCACTG GTGTACGTGA TCGTGGGCAA GCGCTTCCGA 1021 AAGAAGTCTT GGGAGGTGTA CCAGGGAGTG TGCCAGAAAG GGGGCTGCAG GTCAGAACCC 1081 ATTCAGATGG AGAACTCCAT GGGCACACTG CGGACCTCCA TCTCCGTGGA ACGCCAGATT 1141 CACAAACTGC AGGACTGGGC AGGGAGCAGA CAGTGAGCAA ACGCCAGCAG GGCTGCTGTG 1201 AATTTGTGTA AGGATTGAGG GACAGTTGCT T (2) INFORMATION FOR SEQ ID NO:2458: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1201 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2458: 1 ATGTTCTCTC CCTGGAAGAT ATCAATGTTT CTGTCTGTTC GTGAGGACTC CGTGCCCACC 61 ACGGCCTCTT TCAGCGCCGA CATGCTCAAT GTCACCTTGC AAGGGCCCAC TCTTAACGGG 121 ACCTTTGCCC AGAGCAAATG CCCCCAAGTG GAGTGGCTGG GCTGGCTCAA CACCATCCAG 181 CCCCCCTTCC TCTGGGTGCT GTTCGTGCTG GCCACCCTAG AGAACATCTT TGTCCTCAGC 241 GTCTTCTGCC TGCACAAGAG CAGCTGCACG GTGGCAGAGA TCTACCTGGG GAACCTGGCC 301 GCAGCAGACC TGATCCTGGC CTGCGGGCTG CCCTTCTGGG CCATCACCAT CTCCAACAAC 361 TTCGACTGGC TCTTTGGGGA GACGCTCTGC CGCGTGGTGA ATGCCATTAT CTCCATGAAC 421 CTGTACAGCA GCATCTGTTT CCTGATGCTG GTGAGCATCG ACCGCTACCT GGCCCTGGTG 481 AAAACCATGT CCATGGGCCG GATGCGCGGC GTGCGCTGGG CCAAGCTCTA CAGCTTGGTG 541 ATCTGGGGGT GTACGCTGCT CCTGAGCTCA CCCATGCTGG TGTTCCGGAC CATGAAGGAG 601 TACAGCGATG AGGGCCACAA CGTCACCGCT TGTGTCATCA GCTACCCATC CCTCATCTGG WO 00/09525 PCT/US99/17712 EPI-109 599 661 GAAGTGTTCA CCAACATGCT CCTGAATGTC GTGGGCTTCC TGCTGCCCCT GAGTGTCATC 721 ACCTTCTGCA CGATGCAGAT CATGCAGGTG CTGCGGAACA ACGAGATGCA GAAGTTCAAG 781 GAGATCCAGA CGGAGAGGAG GGCCACGGTG CTAGTCCTGG TTGTGCTGCT GCTATTCATC 841 ATCTGCTGGC TGCCCTTCCA GATCAGCACC TTCCTGGATA CGCTGCATCG CCTCGGCATC 901 CTCTCCAGCT GCCAGGACGA GCGCATCATC GATGTAATCA CACAGATCGC CTCCTTCATG 961 GCCTACAGCA ACAGCTGCCT CAACCCACTG GTGTACGTGA TCGTGGGCAA GCGCTTCCGA 1021 AAGAAGTCTT GGGAGGTGTA CCAGGGAGTG TGCCAGAAAG GGGGCTGCAG GTCAGAACCC 1081 ATTCAGATGG AGAACTCCAT GGGCACACTG CGGACCTCCA TCTCCGTGGA ACGCCAGATT 1141 CACAAACTGC AGGACTGGGC AGGGAGCAGA CAGTGAGCAA ACGCCAGCAG GGCTGCTGTG 1201'AATTTGTGTA AGGATTGAGG GACAGTTGCT T (2) INFORMATION FOR SEQ ID NO:2459: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 241 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2459: 1 GCCCTTCAAA GATGAGCTGT TCCCGCCGCC ACTCCAGCTC TGGCTTCTGG GCTCCGAGGA 61 GGGGTGGGGA CGGTGGGGAC ATCAGGCTGC CCCGCAGTAC CAGGGAGCGA CTGAAGTGCC 121 CATGCCGCTT GCTCCGGAGA AGGTGGGTGC CGGGCAGGGG CTGCTCCAGC CGCCTCACCT 181 CTGCTGGGAG GACAAACTGT CCCAGCACAG AGGGAGGGAG GGAGGGCAGG CAGCGGGGAG 241 AAGTTTCCCT GTGGTCGTGG GGAGTT (2) INFORMATION FOR SEQ ID NO:2460: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 241 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2460: 1 GCCCTTCAAA GATGAGCTGT TCCCGCCGCC ACTCCAGCTC TGGCTTCTGG GCTCCGAGGA 61 GGGGTGGGGA CGGTGGTGAC GGTGGGGACA TCAGGCTGCC CCGCAGTACC AGGGAGCGAC 121 TGAAGTGCCC ATGCCGCTTG CTCCGGAGAA GGTGGGTGCC GGGCAGGGGC TGCTCCAGCC 181 GCCTCACCTC TGCTGGGAGG ACAAACTGTC CCAGCACAGA GGGAGGGAGG GAGGGCAGGC 241 AGCGGGGAGA AGTTTCCCTG TGGTCGTGGG GAGTT (2) INFORMATION FOR SEQ ID NO:2461: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1441 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2461: 1 GAGCTCTTCA ATATTTTAGT GAAAGCTATA GATGAGGCTC CATAGGGGAT AAAGCACAGA 61 CACACCTTTT CAGAGGGCTT GTGGACTCTG GGCAGCCTGT CCATAGACCT CTGTCCCCAA 121 CTGGCAAGTC AGGAAACTCC AGATTAAGGA GCCCCAATGT GGTTGAACAG CCAGGTGCAC 181 AGATGAGTCA ACCACACAGC CAGGCCAGGG AGGGCCTTCA CTCAAGAGCC TACAGCCAGT 241 TCACAGCCAA GCCAGGGCTA GCGCCAGGCC ACCCATAAAC TGATCTGAGA CTCTGTTTCC 301 CTGTCTCCAT GATGATGGGA TCAGGCTTGA TTGCTGGTTT GTAGGCTTGT TATGAATCAA 361 GTCACAGGGA AGAGGAGCTG ATGGGCTGGG GGGACGTCCT CTGGCCCTCC TGTCTCTTCC 421 CCAGATCCAC TGGGCCCACT CTTATCTGTT CTCTTCTGAA GGAAGGGTTT TAAGGCTTCA 481 AAAAAAAATG TTTTGAAAGT CCCTGCCCTT TCCAGCTCCT ACCGTCTCAG CCCTGGGAGT 541 GTAAAGTGCT GCAGATAGTT AGTAAGTCTT TGAGCAAAAC TGAGAAAGCC AGCCTGAGCC 601 TTGACATGGG AGAAACCTCC GCCATACATC TCCGAAGAAA CGGCCGCGTG TCTCAGGGGA 661 GCGCAAACAC CCGTACCCAG GAAACAGGAC AGCTTCTGCC ACTGTCGCCC TTGGGAGCCG 721 TACGTGGCAT GACAAAGAAA TCCCAGGACT CCGCCTGCCC ACCTGGCCAC CCTCTGTTTA 781 CACCTTCCGC GTAAACGCCC ACTGTTTACA TCCAAAACTC AGACACAAAA TAACCACCTC 841 AAGAAGATAA ATAATGATAA GAAATAAATG TTACGCGAGG CAAATTTATT CACATGGGGC 901 TTCCCAGGCC ACTTTGTGGT CAGCCGGGAG GGACGTTTTT GCCGTCCCAC GACTCCAACG 961 GGCAGCCGGG CCTACGCAAA CATGGAAATC TTCCAAGAGC CTCCCTGGCC CCCAGGGCTC 1021 AGAGGGTGGC AGAGCGGAGA GCGAAGGTGG CCGCAGCCTT CCCGGCCCCA CAGCCAGCCT 1081 GGCTCCAGCT GGGCAGGAGT GCAGAGCTCA GCTGGAGGCG AGGGGGAAGT GCCCAGGAGG 1141 CTGATGACAT CACTACCCAG CCCTTCAAAG ATGAGCTGTT CCCGCCGCCA CTCCAGCTCT 1201 GGCTTCTGGG CTCCGAGGAG GGGTGGGGAC GGTGGTGACG GTGGGGACAT CAGGCTGCCC 1261 CGCAGTACCA GGGAGCGACT GAAGTGCCCA TGCCGCTTGC TCCGGAGAAG GTGGGTGCCG 1321 GGCAGGGGCT GCTCCAGCCG CCTCACCTCT GCTGGGAGGA CAAACTGTCC CAGCACAGAG 1381 GGAGGGAGGG AGGGCAGGCA GCGGGGAGAA GTTTCCCTGT GGTCGTGGGG AGTTGGGAAA 1441 AGTTCCCTTC CTTCCGGAGG GAGG WO 00/09525 PCT/US99/17712 EPI-109 600 (2) INFORMATION FOR SEQ ID NO:2462: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1381 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2462: 1 CTTTGTGAAG AAGGAATTGG CAACACTGAA ACCTCCAGAA CAAAGGCTGT CACTAAGGTC 61 CCGCTGCCTT GATGGATTAT ACACTTGACC TCAGTGTGAC AACAGTGACC GACTACTACT 121 ACCCTGATAT CTTCTCAAGC CCCTGTGATG CGGAACTTAT TCAGACAAAT GGCAAGTTGC 181 TCCTTGCTGT CTTTTATTGC CTCCTGTTTG TATTCAGTCT TCTGGGAAAC AGCCTGGTCA 241 TCCTGGTCCT TGTGGTCTGC AAGAAGCTGA GGAGCATCAC AGATGTATAC CTCTTGAACC 301 TGGCCCTGTC TGACCTGCTT TTTGTCTTCT CCTTCCCCTT TCAGACCTAC TATCTGCTGG 361 ACCAGTGGGT GTTTGGGACT GTAATGTGCA AAGTGGTGTC TGGCTTTTAT TACATTGGCT 421 TCTACAGCAG CATGTTTTTC ATCACCCTCA TGAGTGTGGA CAGGTACCTG GCTGTTGTCC 481 ATGCCGTGTA TGCCCTAAAG GTGAGGACGA TCAGGATGGG CACAACGCTG TGCCTGGCAG 541 TATGGCTAAC CGCCATTATG GCTACCATCC CATTGCTAGT GTTTTACCAA GTGGCCTCTG 601 AAGATGGTGT TCTACAGTGT TATTCATTTT ACAATCAACA GACTTTGAAG TGGAAGATCT 661 TCACCAACTT CAAAATGAAC ATTTTAGGCT TGTTGATCCC ATTCACCATC TTTATGTTCT 721 GCTACATTAA AATCCTGCAC CAGCTGAAGA GGTGTCAAAA CCACAACAAG ACCAAGGCCA 781 TCAGGTTGGT GCTCATTGTG GTCATTGCAT CTTTACTTTT CTGGGTCCCA TTCAACGTGG 841 TTCTTTTCCT CACTTCCTTG CACAGTATGC ACATCTTGGA TGGATGTAGC ATAAGCCAAC 901 AGCTGACTTA TGCCACCCAT GTCACAGAAA TCATTTCCTT TACTCACTGC TGTGTGAACC 961 CTGTTATCTA TGCTTTTGTT GGGGAGAAGT TCAAGAAACA CCTCTCAGAA ATATTTCAGA 1021 AAAGTTGCAG CCAAATCTTC AACTACCTAG GAAGACAAAT GCCTAGGGAG AGCTGTGAAA 1081 AGTCATCATC CTGCCAGCAG CACTCCTCCC GTTCCTCCAG CGTAGACTAC ATTTTGTGAG 1141 GATCAATGAA GACTAAATAT AAAAAACATT TTCTTGAATG GCATGCTAGT AGCAGTGAGC 1201 AAAGGTGTGG GTGTGAAAGG TTTCCAAAAA AAGTTCAGCA TGAAGGATGC CGTGTGTGTT 1261 GTTGCCAACA CTTGGAACAC AATGACTGGA GACATAGTTG TGCATGCCTG GCACAACATC 1321 AAGCCTGTGA TTGTGTTTAT TGATGATGTT GAACAAGTGG TGGCTTTGAG GGATTCTGTA 1381 TGCCAAGTGG AAAAAAAAGA TGTCTCCGGA ATTCGACAGG TTATCA (2) INFORMATION FOR SEQ ID NO:2463: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 5161 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2463: 1 TTTCATCTCT CCGGGCTTAT TTGCTGGTTT CTCCGAATGC GGGCCTTGTC TCOTTCACGC 61 TGGATCCCCA ACGCCTAGAA CAGTGCGTGG CACGCAGTTC GTCCTTCTAT AAATATCGGA 121 CTAAATGCAT CTCTGTGATG GTAATACCCA CACGGTGTTG TGAGAATGAA TGAGTGATTC 181 TGTGCAAGTT CCTAGTGATC TGTTACAAAA AGTACTGGTC GCTAAATTAC TCTTATAATA 241 AAGCATACTT TTAGGATAAT AAAGCACTAT TCGCGAATTG GTTACCGCTA TTATGAAATT 301 ACTGAGCAAT ACATATCTAC ATCTGATCAG TCTCCAGAAT TATGCCAAAT CCTACCTTCT 361 TCTGAAAGTA TCTCCTAATT ATCTGCACCT GACCCTAGTG ATGCTGTGAA TGTGCAAGTA 421 TAGCTACATC CTCCGAAGGA AGGATCTTTA CTCCTTTTAC CTCCTGAATG GGCTGCGTCT 481 GCTGAAAGCG CGGGGGAATG GGCGGTTGGA AGCTTGGCCC TACTTCCAGC ATTGCCGCCT 541 ACTGGTTGGG TTACTCCAGC AAGTCACTCC CCTTCCCTGG GCCTCAGTGT CTCTACTGTA 601 GCATTCCCAG GTCTGGAATT CCATCCACTT TAGCAAGGAT GGACGCGCCA CAGAGAGACG 661 CGTTCCTAGC CCGCGCTTCC CACCTGTCTT CAGGCGCATC CCGCTTCCCT CAAACTTAGG 721 AAATGCCTCT GGGAGGTCCT GTCCGGCTCC GGACTCACTA CCGACCACCC GCAAACAGCA 781 GGGTCCCCTG GGCTTCCCAA GCCGCGCACC TCTCCGCCCC GCCCCTGCGC CCTCCTTCCT 841 CGCGTCTGCC CCTCTCCCCC ACCCCGCCTT CTCCCTCCCC GCCCCAGCGG CGCATGCGCC 901 GCGCTCGGAG CGTGTTTTTA TAAAAGTCCG GCCGCGGCCA GAAACTTCAG TTTGTTGGCT 961 GCGGCAGCAG GTAGCAAAGT GACGCCGAGG GCCTGAGTGC TCCAGTAGCC ACCGCATCTG 1021 GAGAACCAGC GGTTACCATG GAGGGGATCA GTGTAAGTCC AGTTTCAACC TGCTTTGTCA 1081 TAAATGTACA AACGTTTGAA CTTAGAGCGC AGCCCCTCTC CGAGCGGGCA GAAGCGGCCA 1141 GGACATTGGA GGTACCCGTA CTCCAAAAAA GGGTCACCGA AAGGAGTTTT CTTGACCATG 1201 CCTATATAGT GCGGGTGGGT GGGGGGGGAG CAGGATTGGA ATCTTTTTCT CTGTGAGTCG 1261 AGGAGAAACG ACTGGAAAGA GCGTTCCAGT GGCTGCATGT GTCTCCCCCT TGAGTCCCGC 1321 CGCGCGCGGC GGCTTGCACG CTGTTTGCAA ACGTAAGAAC ATTCTGTCCA CAAGTGCAGA 1381 GAAGGCGTGC GCGCTGCCTC GGGACTCAGA CCACCGGTCT CTTCCTTGGG GAAGCGGGGA 1441 TGTCTTGGAG CGAGTTACAT TGTCTGAATT TAGAGGCGGA GGGCGGCGTG CCTGGGCTGA 1501 CTTCCCAGGA GGAGATTGCG CCCGCTTTAA CTTCGGGGTT AAGCGCCTGG TGACTGTTCT 1561 TGACACTGGG TGCGTGTTTG TTAAACTCTG TGCGGCCGAC GGAGCTGTGC CAGTCTCCCA 1621 GCACAGTAGG CAGAGGGCGG GAGAGGCGGG TGGACCCACC GCGCCGATCC TCTGAGGGGA 1681 TCGAGTGGTG GCAGCAGCTA GGAGTTGATC CGCCCGCGCG CTTTGGGTTT GAGGGGGAAA 1741 CCTTCCCGCC GTCCGAAGCG CGCCTCTTCC CCACGGCCGC GAGTGGGTCC TGCAGTTCGA WO 00/09525 PCT/US99/17712 EPI-I109 601 1801 GAGTTTGGGG TCGTGCAGAG GTCAGCGGAG TGGTTTGACC TCCCCTTTGA CACCGCGCAG 1861 CTGCCAGCCC TGAGATTTGC GCTCCGGGGA TAGGAGCGGG TACGGGGTGA GGGGCGGGGG 1921 CGGTTAAGAC CGCACCTGGG CTGCCAGGTC GCCGCCGCGA AGACTGGCAG GTGCAAGTGG 1981 GGAAACCGTT TGGCTCTCTC CGAGTCCAGT TGTGATGTTT AACCGTCGGT GGTTTCCAGA 2041 AACCTTTTGA AACCCTCTTG CTAGGGAGTT TTTGGTTTCC TGCAGCGGCG CGCAATTCAA 2101 AGACGCTCGC GGCGGAGCCG CCCAGTCGCT CCCCAGCACC CTGTGGGACA GAGCCTGGCG 2161 TGTCGCCCAG CGGAGCCCCT GCAGCGCTGC TTGCGGGCGG TTGGCGTGGG TGTAGTGGGC 2221 AGCCGCGGCG GCCCGGGGCT GGACGACCCG GCCCCCCGCG TGCCCACCGC CTGGAGGCTT 2281 CCAGCTGCCC ACCTCCGGCC GGGTTAACTG GATCAGTGGC GGGGTAATGG GAAGCCACCC 2341 GGGAGAGTGA GGAAATGAAA CTTGGGGCGA GGACCACGGG TGCAGACCCC GTTACCTTCT 2401 CCACCCAGGA AAATGCCCCG CTCCCTAACG TCCCAAACGC GCCAAGTGAT AAACACGAGG 2461 ATGGCAAGAG ACCCACACAC CGGAGGAGCG CCCGCTTGGG GGAGGAGGTG CCGTTTGTTC 2521 ATTTTCTGAC ACTCCCGCCC AATATACCCC AAGCACCGAA GGGCCTTCGT TTTAAGACCG 2581 CATTCTCTTT ACCCACTACA AGTTGCTTGA AGCCCAGAAT GGTTTGTATT TAGGCAGGCG 2641 TGGGAAAATT AAGTTTTTGC GCTTTAGGAG AATGAGTCTT TGCAACGCCC CCGCCCTCCC 2701 CCCGTGATCC TCCCTTCTCC CCTCTTCCCT CCCTGGGCGA AAAACTTCTT ACAAAAAGTT 2761 AATCACTGCC CCTCCTAGCA GCACCCACCC CACCCCCCAC GCCGCCTGGG AGTGGCCTCT 2821 TTGTGTGTAT TTTTTTTTTC CTCCTAAGGA AGGTTTTTTT TCTTCCCTCT AGTGGGCGGG 2881 GCAGAGGAGT TAGCCAAGAT GTGACTTTGA AACCCTCAGC GTCTCAGTGC CCTTTTGTTC 2941 TAAACAAAGA ATTTTGTAAT TGGTTCTACC AAAGAAGGAT ATAATGAAGT CACTATGGGA 3001 AAAGATGGGG AGGAGAGTTG TAGGATTCTA CATTAATTCT CTTGTGCCCT TAGCCCACTA 3061 CTTCAGAATT TCCTGAAGAA AGCAAGCCTG AATTGGTTTT TTAAATTGCT TTAAAAATTT 3121 TTTTTAACTG GGTTAATGCT TGCTGAATTG GAAGTGAATG TCCATTCCTT TGCCTCTTTT 3181 GCAGATATAC ACTTCAGATA ACTACACCGA GGAAATGGGC TCAGGGGACT ATGACTCCAT 3241 GAAGGAACCC TGTTTCCGTG AAGAAAATGC TAATTTCAAT AAAATCTTCC TGCCCACCAT 3301 CTACTCCATC ATCTTCTTAA CTGGCATTGT GGGCAATGGA TTGGTCATCC TGGTCATGGG 3361 TTACCAGAAG AAACTGAGAA GCATGACGGA CAAGTACAGG CTGCACCTGT CAGTGGCCGA 3421 CCTCCTCTTT GTCATCACGC TTCCCTTCTG GGCAGTTGAT GCCGTGGCAA ACTGGTACTT 3481 TGGGAACTTC CTATGCAAGG CAGTCCATGT CATCTACACA GTCAACCTCT ACAGCAGTGT 3541 CCTCATCCTG GCCTTCATCA GTCTGGACCG CTACCTGGCC ATCGTCCACG CCACCAACAG 3601 TCAGAGGCCA AGGAAGCTGT TGGCTGAAAA GGTGGTCTAT GTTGGCGTCT GGATCCCTGC 3661 CCTCCTGCTG ACTATTCCCG ACTTCATCTT TGCCAACGTC AGTGAGGCAG ATGACAGATA 3721 TATCTGTGAC CGCTTCTACC CCAATGACTT GTGGGTGGTT GTGTTCCAGT TTCAGCACAT 3781 CATGGTTGGC CTTATCCTGC CTGGTATTGT CATCCTGTCC TGCTATTGCA TTATCATCTC 3841 CAAGCTGTCA CACTCCAAGG GCCACCAGAA GCGCAAGGCC CTCAAGACCA CAGTCATCCT 3901 CATCCTGGCT TTCTTCGCCT GTTGGCTGCC TTACTACATT GGGATCAGCA TCGACTCCTT 3961 CATCCTCCTG GAAATCATCA AGCAAGGGTG TGAGTTTGAG AACACTGTGC ACAAGTGGAT 4021 TTCCATCACC GAGGCCCTAG CTTTCTTCCA CTGTTGTCTG AACCCCATCC TCTATGCTTT 4081 CCTTGGAGCC AAATTTAAAA CCTCTGCCCA GCACGCACTC ACCTCTGTGA GCAGAGGGTC 4141 CAGCCTCAAG ATCCTCTCCA AAGGAAAGCG AGGTGGACAT TCATCTGTTT CCACTGAGTC 4201 TGAGTCTTCA AGTTTTCACT CCAGCTAACA CAGATGTAAA AGACTTTTTT TTATACGATA 4261 AATAACTTTT TTTTAAGTTA CACATTTTTC AGATATAAAA GACTGACCAA TATTGTACAG 4321 TTTTTATTGC TTGTTGGATT TTTGTCTTGT GTTTCTTTAG TTTTTGTGAA GTTTAATTGA 4381 CTTATTTATA TAAATTTTTT TTGTTTCATA TTGATGTGTG TCTAGGCAGG ACCTGTGGCC 4441 AAGTTCTTAG TTGCTGTATG TCTCGTGGTA GGACTGTAGA AAAGGGAACT GAACATTCCA 4501 GAGCGTGTAG TGAATCACGT AAAGCTAGAA ATGATCCCCA GCTGTTTATG CATAGATAAT 4561 CTCTCCATTC CCGTGGAACG TTTTTCCTGT TCTTAAGACG TGATTTTGCT GTAGAAGATG 4621 GCACTTATAA CCAAAGCCCA AAGTGGTATA GAAATGCTGG TTTTTCAGTT TTCAGGAGTG 4681 GGTTGATTTC AGCACCTACA GTGTACAGTC TTGTATTAAG TTGTTAATAA AAGTACATGT 4741 TAAACTTACT TAGTGTTATG TTCTGATTTC TGTTGACATT CTTTTGGCTA GTAGAAGACA 4801 AAAGTAATAC ATTTATGGTA TGCAAAGCAC TATCCTAGGT ATTTCATTGT AATATTTTAC 4861 TTACCCCTTA TCACAACTCT GATAGATTCT GCTTCTGTTA CTAATTACAT TTTATAGAAG 4921 AGGAAACGGA GGCACAGAAA GCCTAAGTAA CTTGGTTAAA GGCATGTAGT AAGTATCAAA 4981 TCCTGTATTT TAAACCAGGT AACATGACTT AACGAATCTG AAGCCTTCAC CACTTTAAAT 5041 TCAAATGGAA GTTTAGAAAT GGCCAGCCAG CACCTATTTG TATGAAAGGT CATCTTTCAG 5101 AGGATAAGCA TGTATAAAGA AGAAAAGGTA TGCAGTCGTG TTTGGATTTT ACTCCACCAT 5161 C (2) INFORMATION FOR SEQ ID NO:2464: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 841 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2464: 1 AGGATGATGG TGATGGGGAA CTAAATGGGG AAATATGGAA GGTCACAGGA AAAGTTAACA 61 CAAGTTAGCA AAAAGTTAAC ATAACACAAA AAGGTCTTGC AGGAAAAAAA AAAGAAAAGA 121 AAAGAAAGAA AAAGTCTCCA AGAATGGTTT GGACAGCCAA AATGAATACT TATAGTCACG 181 TATACCTGCT CACTCCTGAC GCTTCACTCA CACACAGCAC AGGATCTGGT GAGGCTATCA WO 00/09525 PCT/US99/17712 EPI-109 602 241 CTAAATGTGC CACATTGTGG TTAAGTTTTA CCTGATTAAC GAAATGCTCA CACTTCTAAA 301 CTGAGGTCCT TACAGTAGAT TCCTTTTGCA AGATTGTTAC TGGCTTACAA CTTAAAAATA 361 AAGGAAAATC ACAAGGAAAG AAAAGTGGGG AAAAAATCGG AGGAAACTTG CCCCTGCCCT 421 GGCCACCGGC AAGGCTGCCA CAAAGGGGTT AAAAGTTAAG TGGAAGTGGA GCTTGAAGAA 481 GTGGGATGGG GCCTCTCCAG GAAAGCTGAA CGAGGCATCT GGAGCCCGAA CAAACCTCCA 541 CCTTTTTTGG CCTCGACGGC GGCAACCCAG CCTCCCTCCT AACGCCCTCC GCCTTTGGGA 601 CCAACCAGGG GAGCTCAAGT TAGTAGCAGC CAAGGAGAGG CGCTGCCTTG CCAAGACTAA 661 AAAGGGAGGG GAGAAGAGAG GAAAAAAGCA AGAATCCCCC ACCCCTCTCC CGGGCGGAGG 721 GGGCGGGAAG AGCGCGTCCT GGCCAAGCCG AGTAGTGTCT TCCACTCGGT GCGTCTCTCT 781 AGGAGCCGCG CGGGAAGGAT GCTGGTCCGC AGGGGCGCGC GCGCAGGGCC CAGGATGCCG 841 CGGGGCTGGA CCGCGCTTTG CTTGCTGAGT TTGCTGC (2) INFORMATION FOR SEQ ID NO:2465: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 2581 base. pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2465: 1 CCTTTTTTGG CCTCGACGGC GGCAACCCAG CCTCCCTCCT AACGCCCTCC GCCTTTGGGA 61 CCAACCAGGG GAGCTCAAGT TAGTAGCAGC CAAGGAGAGG CGCTGCCTTG CCAAGACTAA 121 AAAGGGAGGG GAGAAGAGAG GAAAAAAGCA AGAATCCCCC ACCCCTCTCC CGGGCGGAGG 181 GGGCGGGAAG AGCGCGTCCT GGCCAAGCCG AGTAGTGTCT TCCACTCGGT GCGTCTCTCT 241 AGGAGCCGCG CGGGAAGGAT GCTGGTCCGC AGGGGCGCGC GCGAGGGCCC AGGATGCCGC 301 GGGGCTGGAC CGCGCTTTGC TTGCTGAGTT TGCTGCCTTC TGGGTTCATG AGTCTTGACA 361 ACAACGGTAC TGCTACCCCA GAGTTACCTA CCCAGGGAAC ATTTTCAAAT GTTTCTACAA 421 ATGTATCCTA CCAAGAAACT ACAACACCTA GTACCCTTGG AAGTACCAGC CTGCACCCTG 481 TGTCTCAACA TGGCAATGAG GCCACAACAA ACATCACAGA AACGACAGTC AAATTCACAT 541 CTACCTCTGT GATAACCTCA GTTTATGGAA ACACAAACTC TTCTGTCCAG TCACAGACCT 601 CTGTAATCAG CACAGTGTTC ACCACCCCAG CCAACGTTTC AACTCCAGAG ACAACCTTGA 661 AGCCTAGCCT GTCACCTGGA AATGTTTCAG ACCTTTCAAC CACTAGCACT AGCCTTGCAA 721 CATCTCCCAC TAAACCCTAT ACATCATCTT CTCCTATCCT AAGTGACATC AAGGCAGAAA 781 TCAAATGTTC AGGCATCAGA GAAGTGAAAT TGACTCAGGG CATCTGCCTG GAGCAAAATA 841 AGACCTCCAG CTGTGCGGAG TTTAAGAAGG ACAGGGGAGA GGGCCTGGCC CGAGTGCTGT 901 GTGGGGAGGA GCAGGCTGAT GCTGATGCTG GGGCCCAGGT ATGCTCCCTG CTCCTTGCCC 961 AGTCTGAGGT GAGGCCTCAG TGTCTACTGC TGGTCTTGGC CAACAGAACA GAAATTTCCA 1021 GCAAACTCCA ACTTATGAAA AAGCACCAAT CTGACCTGAA AAAGCTGGGG ATCCTAGATT 1081 TCACTGAGCA AGATGTTGCA AGCCACCAGA GCTATTCCCA AAAGACCCTG ATTGCACTGG 1141 TCACCTCGGG AGCCCTGCTG GCTGTCTTGG GCATCACTGG CTATTTCCTG ATGAATCGCC 1201 GCAGCTGGAG CCCCACAGGA GAAAGGCTGG GCGAAGACCC TTATTACACG GAAAACGGTG 1261 GAGGCCAGGG CTATAGCTCA GGACCTGGGA CCTCCCCTGA GGCTCAGGGA AAGGCCAGTG 1321 TGAACCGAGG GGCTCAGAAA AACGGGACCG GCCAGGCCAC CTCCAGAAAC GGCCATTCAG 1381 CAAGACAACA CGTGGTGGCT GATACCGAAT TGTGACTCGG CTAGGTGGGG CAAGGCTGGG 1441 CAGTGTCCGA GAGAGCACCC CTCTCTGCAT CTGACCACGT GCTACCCCCA TGCTGGAGGT 1501 GACATCTCTT ACGCCCAACC CTTCCCCACT GCACACACCT CAGAGGCTGT TCTTGGGGCC 1561 CTACACCTTG AGGAGGGGGC AGGTAAACTC CTGTCCTTTA CACATTCGGC TCCCTGGAGC 1621 CAGACTCTGG TCTTCTTTGG GTAAACGTGT GACGGGGGAA AGCCAAGGTC TGGAGAAGCT 1681 CCCAGGAACA ATCGATGGCC TTGCAGCACT CACACAGGAC CCCCTTCCCC TACCCCCTCC 1741 TCTCTGCCGC AATACAGGAA CCCCCAGGGG AAAGATGAGC TTTTCTAGGC TACAATTTTC 1801 TCCCAGGAAG CTTTGATTTT TACCGTTTCT TCCCTGTATT TTCTTTCTCT ACTTTGAGGA 1861 AACCAAAGTA ACCTTTTGCA CCTGCTCTCT TGTAATGATA TAGCCAGAAA AACGTGTTGC 1921 CTTGAACCAC TTCCCTCATC TCTCCTCCAA GACACTGTGG ACTTGGTCAC CAGCTCCTCC 1981 CTTGTTCTCT AAGTTCCACT GAGCTCCATG TGCCCCCTCT ACCATTTGCA GAGTCCTGCA 2041 CAGTTTTCTG GCTGGAGCCT AGAACAGGCC TCCCAAGTTT TAGGACAAAC AGCTCAGTTC 2101 TAGTCTCTCT GGGGCCACAC AGAAACTCTT TTTGGGCTCC TTTTTCTCCC TCTGGATCAA 2161 AGTAGGCAGG ACCATGGGAC CAGGTCTTGG AGCTGAGCCT CTCACCTGTA CTCTTCCGAA 2221 AAATCCTCTT CCTCTGAGGC TGGATCCTAG CCTTATCCTC TGATCTCCAT GGCTTCCTCC 2281 TCCCTCCTGC CGACTCCTGG GTTGAGCTGT TGCCTCAGTC CCCCAACAGA TGCTTTTCTG 2341 TCTCTGCCTC CCTCACCCTG AGCCCCTTCC TTGCTCTGCA CCCCCATATG GTCATAGCCC 2401 AGATCAGCTC CTAACCCTTA TCACCAGCTG CCTCTTCTGT GGGTGACCCA GGTCCTTGTT 2461 TGCTGTTGAT TTCTTTCCAG AGGGGTTGAG CAGGGATCCT GGTTTCAATG ACGGTTGGAA 2521 ATAGAAATTT CCAGAGAAGA GAGTATTGGG TAGATATTTT TTCTGAATAC AAAGTGATGT 2581 GTTTAAATAC TGCAATTAAA GTGATACTGA AACAC (2) INFORMATION FOR SEQ ID NO:2466: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 3422 baseApairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear WO 00/09525 PCT/US99/17712 EPI-109 603 (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2466: AGGATGATGG TGATGGGGAA CTAAATGGGG AAATATGGAA GGTCACAGGA AAAGTTAACA CAAGTTAGCA AAAGTTAAC ATAACACAAA AAGGTCTTGC AGGAAAAAAA AAAGAAAAGA AAAGAAAGAA AAAGTCTCCA AGAATGGTTT GGACAGCCAA AATGAATACT TATAGTCACG TATACCTGCT CACTCCTGAC GCTTCACTCA CACACAGCAC AGGATCTGGT GAGGCTATCA TAAATGTGC CACATTGTGG TTAAGTTTTA CCTGATTAAC GAAATGCTCA CACTTCTAAA CTGAGGTCCT TACAGTAGAT TCCTTTTGCA AGATTGTTAC TGGCTTACAA CTTAAAAATA AAGGAAAATC ACAAGGAAAG AAAAGTGGGG AAAAAATCGG AGGAAACTTG CCCCTGCCCT GGCCACCGGC AAGGCTGCCA CAAAGGGGTT AAAAGTTAAG TGGAAGTGGA GCTTGAAGAA GTGGGATGGG GCCTCTCCAG GAAAGCTGAA CGAGGCATCT GGAGCCCGAA CAAACCTCCA CCTTTTTTGG CCTCGACGGC GGCAACCCAG CCTCCCTCCT AACGCCCTCC GCCTTTGGGA CCAACCAGGG GAGCTCAAGT TAGTAGCAGC CAAGGAGAGG CGCTGCCTTG CCAAGACTAA AAAGGGAGGG GAGAAGAGAG GAAAAAAGCA AGAATCCCCC ACCCCTCTCC CGGGCGGAGG GGGCGGGAAG AGCGCGTCCT GGCCAAGCCG AGTAGTGTCT TCCACTCGGT GCGTCTCTCT AGGAGCCGCG CGGGAAGGAT GCTGGTCCGC AGGGGCGCGC GCGCAGGGCC CAGGATGCCG CGGGGCTGGA CCGCGCTTTG CTTGCTGAGT TTGCTGC CCTTTTTTGG CCTCGACGGC GGCAACCCAG CCTCCCTCCT AACGCCCTCC GCCTTTGGGA CCAACCAGGG GAGCTCAAGT TAGTAGCAGC CAAGGAGAGG CGCTGCCTTG CCAAGACTAA AAAGGGAGGG GAGAAGAGAG GAAAAAAGCA AGAATCCCCC ACCCCTCTCC CGGGCGGAGG GGGCGGGAAG AGCGCGTCCT GGCCAAGCCG AGTAGTGTCT TCCACTCGGT GCGTCTCTCT AGGAGCCGCG CGGGAAGGAT GCTGGTCCGC AGGGGCGCGC GCGAGGGCCC AGGATGCCGC GGGGCTGGAC CGCGCTTTGC TTGCTGAGTT TGCTGCCTTC TGGGTTCATG AGTCTTGACA ACAACGGTAC TGCTACCCCA GAGTTACCTA CCCAGGGAAC ATTTTCAAAT GTTTCTACAA ATGTATCCTA CCAAGAAACT ACAACACCTA GTACCCTTGG AAGTACCAGC CTGCACCCTG TGTCTCAACA TGGCAATGAG GCCACAACAA ACATCACAGA AACGACAGTC AAATTCACAT CTACCTCTGT GATAACCTCA GTTTATGGAA ACACAAACTC TTCTGTCCAG TCACAGACCT CTGTAATCAG CACAGTGTTC ACCACCCCAG CCAACGTTTC AACTCCAGAG ACAACCTTGA AGCCTAGCCT GTCACCTGGA AATGTTTCAG ACCTTTCAAC CACTAGCACT AGCCTTGCAA CATCTCCCAC TAAACCCTAT ACATCATCTT CTCCTATCCT AAGTGACATC AAGGCAGAAA TCAAATGTTC AGGCATCAGA GAAGTGAAAT TGACTCAGGG CATCTGCCTG GAGCAAAATA AGACCTCCAG CTGTGCGGAG TTTAAGAAGG ACAGGGGAGA GGGCCTGGCC CGAGTGCTGT GTGGGGAGGA GCAGGCTGAT GCTGATGCTC GGGCCCAGGT ATGCTCCCTG CTCCTTGCCC AGTCTGAGGT GAGGCCTCAG TGTCTACTGC TGGTCTTGGC CAACAGAACA GAAATTTCCA GCAAACTCCA ACTTATGAAA AAGCACCAAT CTGACCTGAA AAAGCTGGGG ATCCTAGATT TCACTGAGCA AGATGTTGCA AGCCACCAGA GCTATTCCCA AAAGACCCTG ATTGCACTGG TCACCTCGGG AGCCCTGCTG GCTGTCTTGG GCATCACTGG CTATTTCCTG ATGAATCGCC GCAGCTGGAG CCCCACAGGA GAAAGGCTGG GCGAAGACCC TTATTACACG GAAAACGGTG GAGGCCAGGG CTATAGCTCA GGACCTGGGA CCTCCCCTGA GGCTCAGGGA AAGGCCAGTG TGAACCGAGG GGCTCAGAAA AACGGGACCG GCCAGGCCAC CTCCAGAAAC GGCCATTCAG CAAGACAACA CGTGGTGGCT GATACCGAAT TGTGACTCGG CTAGGTGGGG CAAGGCTGGG CAGTGTCCGA GAGAGCACCC CTCTCTGCAT CTGACCACGT GCTACCCCCA TGCTGGAGGT GACATCTCTT ACGCCCAACC CTTCCCCACT GCACACACCT CAGAGGCTGT TCTTGGGGCC CTACACCTTG AGGAGGGGGC AGGTAAACTC CTGTCCTTTA CACATTCGGC TCCCTGGAGC CAGACTCTGG TCTTCTTTGG GTAAACGTGT GACGGGGGAA AGCCAAGGTC TGGAGAAGCT CCCAGGAACA ATCGATGGCC TTGCAGCACT CACACAGGAC CCCCTTCCCC TACCCCCTCC TCTCTGCCGC AATACAGGAA CCCCCAGGGG AAAGATGAGC TTTTCTAGGC TACAATTTTC TCCCAGGAAG CTTTGATTTT TACCGTTTCT TCCCTGTATT TTCTTTCTCT ACTTTGAGGA AACCAAAGTA ACCTTTTGCA CCTGCTCTCT TGTAATGATA TAGCCAGAAA AACGTGTTGC CTTGAACCAC TTCCCTCATC TCTCCTCCAA GACACTGTGG ACTTGGTCAC CAGCTCCTCC CTTGTTCTCT AAGTTCCACT GAGCTCCATG TGCCCCCTCT ACCATTTGCA GAGTCCTGCA CAGTTTTCTG GCTGGAGCCT AGAACAGGCC TCCCAAGTTT TAGGACAAAC AGCTCAGTTC TAGTCTCTCT GGGGCCACAC AGAAACTCTT TTTGGGCTCC TTTTTCTCCC TCTGGATCAA AGTAGGCAGG ACCATGGGAC CAGGTCTTGG AGCTGAGCCT CTCACCTGTA CTCTTCCGAA AAATCCTCTT CCTCTGAGGC TGGATCCTAG CCTTATCCTC TGATCTCCAT GGCTTCCTCC TCCCTCCTGC CGACTCCTGG GTTGAGCTGT TGCCTCAGTC CCCCAACAGA TGCTTTTCTG TCTCTGCCTC CCTCACCCTG AGCCCCTTCC TTGCTCTGCA CCCCCATATG GTCATAGCCC AGATCAGCTC CTAACCCTTA TCACCAGCTG CCTCTTCTGT GGGTGACCCA GGTCCTTGTT TGCTGTTGAT TTCTTTCCAG AGGGGTTGAG CAGGGATCCT GGTTTCAATG ACGGTTGGAA ATAGAAATTT CCAGAGAAGA GAGTATTGGG TAGATATTTT TTCTGAATAC AAAGTGATGT GTTTAAATAC TGCAATTAAA GTGATACTGA ACCAC 3422 (2) INFORMATION FOR SEQ ID NO:2467: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 8101 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2467: 1 TCCCAGTTAA TACATAATCA ATATGCAATT TATTAATACA TCTCTCCATG TCCACTCCCC 61CTGTATCTTG CCATTCTTGA CCTGCATTTC CATCCTCCTT ACCTTCCCTA GAGGCCAACT 121 CATTTTCTTT GAAAAACCTG GCATTTCCCA GAAAAAAAAG TGAAGGGCTG GGAGCTGTCC 181 GTTGTCCTGA TTTGCTCCCT CTGCCCTTGC TTCCAAATGT GGTTGGAAAG AAGCACTATT 241 GAAAAATCCC TAAACGCACC CCTGCAGGGT TGGCTCTACC CTGTAGCCAT GGACACATGC 301 TGTTGATACC ACCTGCCTCA TGAGTCTCAC ATAATTTGCC CTTTCACACT ATCTACCCCA 361 TCAGCCTTAC CAAAACCATA CCTGCATCCT GGGCAGCATC TGCCCTTCAA GAGACTAAGG 421 AATCTCCTTG CAACCAAGAA TGACTAGACC AATGAGACAC CCTTTAAGGC CCCAGCACAA 481 TATAGAAATC CCACAATATG GTAATCCCAG TAAGGAGCTA TCAAGCCATT GCAGGACCAT 541 CTAGAATACA ACTAGAGTAT AGTTCCTTTC AATCCAGGAA CTATACTCTA ACAGCTTGGC WO 00/09525 PCT/US99/17712 EPI-109 604 601 TCACAGGAAC CAGAAGTGAA GATGATGAGG ATCAGGGCTG AGCCTGTGAG CACCAGCTCC 661 ACCACTGACA CCAACCACAG ATTAAACAAG CATCTTGTGG ACCCCTGGGA TGGAAAGAAT 721 AGTTGTTGCC TTATCAACCT CCCCCACAGC CCACACAGAA AAGATAAAAT CATCATGGCT 781 ACAGTGTTAC AGAAGATGAT GACCCAAGGA GTAGGCCTGC CTGAGTGAAT GCTGAGAGTG 841 ATAATGGGAG CAGTAGCATC TCAGAGACTA CAGCAGAAAC CATCCACATA AAGAGCTTTG 901 CCCAAACTTA TGATAAAGGG CACCCTCAGA GACTCTCCCT ACTTTAATAT TAGCCCATTG 961 CAGAAATGGT GAGTGGAAAG AGAAATCTTA GGAAGAACCC CTTAAAAAAG CAAAATGCTT 1021 TTTAGGTTTG TGCTGAAGAG CCTGGAAAAG AAATAAGGAC ACACACGCTG AGAAATCTTC 1081 CTCCTGCCCC AACACTGGGA TAATCTCCAA GGATCTCTCC ATATCTCATT CTCCTGGATA 1141 CACTGTCCAC TCAGAAATAT TGTGCAGAGT GCAGTAATTC AAAAGTGAGC TATTGTGTTA 1201 GGAGTGAAGG CAAGAGTATC GTAAAATAAA TCAAATTTGA AATGAATTCT CTTAAATTGC 1261 TTTATAGATG TTTAATGTAA GCCAGCAGCT ATTAAACGAT AAACCTTAAA TTCGAGAAAA 1321 ACTTGGTCAT TCAGAAACTA TAGAAACAGG CAGGACTTAT TGCGAGGGCA AACACAGAGT 1381 GAGCTCCAGC CTGCTTCAGG AAAATCTGCC AGTGCCATGA AGGATGTACT CTGTCTGCTC 1441 CACTGCACTA CTGCTCAGTA TGAGCCCATG CCATCAGCTG TCCCTGACCC ACAGGAGTTC 1501 TTTAGAAGAG ACTGGTCAAC AAAAGTTTCT AGGGTGTTTT ATACCTGCCA ACTCGAGGGT 1561 TAAAACAAGT TGCATAGAAA TGCTCAATCA AGAAAGACAC AGTCATTACT CAGAGAATAA 1621 TAAACAGCCT GGCAGCACAT GAATGAATAG AAAAAAGATG TTACATGCAA AGCATGAAAT 1681 AACCAAATTC CATAACAGAT GTTAATCTGT AATGTGTTTA GGAGAATTTA GAGGAAGTAT 1741 AAGATTTATT CTTTCATCAA AAAAATTATA GCCAATGAGG ATATATCTAT CAATTATCCA 1801 TCAAGTGGTG ATATGGCAGC ACAAGGTAAA ACACAAAGGA ATAAAACCAA CGTTTATTAA 1861 GAACCAATCA TGTGGCATTT CACATTGAGC ATCATATTTA ATTCTGAAAA AAATCCTTGT 1921 ACTGTATCAT TCTTCATATT TTATGGATGC AGTAACTAAG GCTGAGAACT TTAAAATTTT 1981 TCCTAAGTTC AGACACATAG CTAAGTGGCA GAACCAAGAT TCAAACTCAC CCCATCTAAC 2041 TGCAGAGCAA ACTGCATGCC TTAAATGTCA AAGTGAATAC TAGCACAGTT AATACAATGT 2101 TTGGAAACTC AGAGAAGGAA TGATCCCTCT GCATTATAGT TACTAAGGAA TCATTGCCAT 2161 TATTTAAATG CCAGTGCTTC TACATCAGGC CCAAATTTTC TGTCCTACTA ACTGTGAATC 2221 AAGACTTGAT TCAACCTCTA CTTGAGTATC TGCCGCAATG AGAAATCACT TACCTCCACT 2281 AACCACACAT TTATTTTATA ACAACAGATT GTTAGTAAGT CCTTTCTTAT ACATACTCAA 2341 CAGCTGCTTC CCAAGATGCT GTAGGATTAT GTCTAGAGTC AAACTAGCCA GAAGCAATGT 2401 CCAAAATACA CCATAACACT GTGCAGCAAA GGTCCTACTA CCACTTGTTT GGCCCAAACA 2461 TTCTAGGCAG CACTGGATAT CTGAATCATC AATTATTTCC ACAAACACTG ACCCCTCTAC 2521 CAGTCACCCT CACTAGAAGA ATTAATTCCA CATGATAATA GCTCCCTCAT GTTACTCCCT 2581 TCTAAGTCAA ATTGTACACC CCTTTATCTG ATTAACAGAG TCTAAGTCAC ATGACCTAAA 2641 TGCAAGAGAA CTGGGAATGG ACGTTTGTGG ATTCTACCTT AGTAAGGCAA AGTTATCATT 2701 GGGAATTCCT CTAATACAGG AAGGGTGTTC CAGAGACATT AAGGAGCCAT ATAAATGGAA 2761 AATGTCCACT ACAATCCATC ACTTGGTTGC CCCACATCAA CATTCATTCT TTTGCCACAC 2821 TTAAAGTTTC CAAGAACAAA AATTATCCCA CTGAACATAA TCTTTACTAT CTTTTATATA 2881 AAGGAAAATT AGACTTGACT CAGCAGAACT GAAATAACCC AGCTCTAACA GTTACTGCTT 2941 TTAACTTCAA GTACTGTGTC TCTAGGTGAT ACCTGCTCCA ACAATAGTTT GGTCACATTT 3001 TCAATTTGAT ATTCTCTAGT CTCCCAACTT GATAACTGTA CCCTAAACCA TAAAGTTCAC 3061 TACCAACATG CTATATATAA AATAACCAAA GGGGGAAGAA GAAAGAGAAA AAGGAAATCT 3121 CTTAAAATAC ACAGGTATAC ATATGACAAA GCAAAGAAGG AAATGTGAGC AGATAGTGCA 3181 GTCCTCGTTT CTGAAATTGG TCCCCTGACT GGGGCTATAC CTATTCCATT TCCTCACCCT 3241 CAGCCAGGCA GGTGGAGCAA AAACTTAAGT CTTGGTGGAT CTGAATCTTG ATGCTGTGGA 3301 GCTGTCTTAC TAGCCCCAGA CTACCTGCCT CTCAATTTCT AATTATATCA GTGAAAGCAA 3361 ACAGCTTTGA TTTGTTTAAG CCTCTGATTT TTTGGTCTAA CTGATGTAAG ACCACAAGGA 3421 CAAGAGTTCT CCAGCTCCGG ATTCTCTTCT GTTCTGTTAA TGGTGAAATG CCCGAGAGAA 3481 GAGTTGCCAA CTTTGGCAAA TAAAAAATAC AGGATTCCAG TTAAATTCAA ATTTAGATAA 3541 ACAACAATTT TTTAGTATTA GTGTGTCCCA TTCAATATTT GGACATACTT AACTAAAAAA 3601 TGATTTGTTG TTCATCTGAA ATACAAATTT AACTGGGCAT TCTGAATATT CTCTGGCAAC 3661 CCCCGAGAGA GTGAAGAAAG TGGTACAAGG ACACTTAAGA AGACCAGATT TGAAAAGACA 3721 TTACGGATGT GTTTAAATGT CTTATTCTAG AGAGAGTTAG AGCTGTAGGT AGAACTTGGG 3781 AAATTAAGTT AAAAGCAGAC ACAGAGACCT GGCCAATATA TACTAAGGAG TGGATCACTC 3841 TGGTCACAAG CCCAACCTGA GACCAAGGGC ATAGTGAGAT GATTTGGGAA AGGCACTTAT 3901 ACACTACTCA TCCCCGTCTT TGAACTAAAT GCCTTATAAA TCTCCAAGAG AAATGACAGT 3961 CCACCATGTG GACTGCTTTC TGTAAGTCCA GGGAAAATAA AAGCTATGTG CTTGAAACCC 4021 ACTTCTGATA TTATAAGGTG TGTGATCTTT GTCATGTTAA TGGGTCTGAG TATCAATTCT 4081 ACAATTGTAA AGTGACAGTA ATGGTGTGTC CCCAGGTTGT TGTGGAAAGC TTGATTCTTA 4141 ATGCAACAGT AGGAAACCCC AGCCTCTCTG GAGCAAACAC CCTTCTACAT CTTTACTTCC 4201 CCTGCACATT GGCAGGACTC TATTCCTCTA TTTCTCTCTA GTGCTAGAGC AGAAAGGGAC 4261 CTTGATTTGA TATCAGGAAA ATCTATTTCT GAACCATAAG CTATGATAGC TGATTTAAAA 4321 AATTGACTAT CATGACATGA TAATGATCAT AATGGTAATA CATATTGATA GGGTTGCCGT 4381 GAAAGTAATA ATATATCTAA GAGTTGTGAC AATATATGAT ACGCCTAGAC TCTCAGAAAA 4441 TGCTAATTCC AATCCCAATT GCTCTTTGCA TAAAGTTCTG TCCTAGGGTC TGTTCTTTTC 4501 CCACATCTAC CCTCCTTGGA TCTCTCTTCT GTCTTTTTCA TGTGGTTCAG AGGAGGAGAG 4561 AGATCCAGGT CAATGTTTTT CAAATTACAA GGAATTATCA TTTAAATGGG GAAGAAGCTC 4621 AAGTTTTGAC GTGTAGTGGA ATTGGAGTGG AGTGGAGTGG AATGGAAACT AACAGGAAGA WO 00/09525 PCT/US99/17712 EPI-109 605 4681 CACTGCACAT GGTTAAGATA AAGATTGTTT CCTGAAACCT TTAATTTGTG CTTACATACT 4741 CACACATACA TATGTGCATG CACTGGGACT CTGCAATATG CATTTCTGAC TATGGAACAT 4801 AGCCATAAAA GTCTTTGCAC TGAACGTTCA GTGGGCCTTT CACAAGCTGC CCTAATTGGG 4861 AAAGAAAAAC ATGGTCCCTC CATTTCCTGC CCCCAACTCC AGAAAAGTCA CCATAGTTGA 4921 GGGTACATCT GAGAAGCCAG CACTTGGGAG TTCAGGGCTC AAGTTCCTTT CTAGAAAAAC 4981 ACTGGGTGAT TCTAGGGGAA CTTCCGATCA GAAACAGCCA ATTCAGAGTG AGAGAAGAAA 5041 ACGTGACCAT GCAGTTCCTG TGGTTACCAG CCTTGCCCCT CTCTTGCCTT CTGGGAGTTA 5101 TAAAACCCAA GACTGGAAAG GAAAACCAGC ATTTGCTCAG GCAGCCTCTC TGGGAAGATG 5161 CTGCTTCTTC CTCTCCCCCT GCTGCTCTTT CTCTTGTGCT CCAGAGCTGA AGCTGGTGAG 5221 TATCAGGGTT CTTCCCTCTG AAATCTGCAG TATCAGCTCC TGAAACAAAG ATGTTTAGTC 5281 TGAAATAGCT GACTCCTAAA CAGGGTTCCA AGATCTCTCT TCAAGAGTCC CACAGAGGAA 5341 ATTTCCACTT GGGATGTGTG CCACCCCACC CCCACCCCCA CCCACTGCCA TTCTCTACAG 5401 CCTAGGACAC CCCCAGGAAC AAGGAATTTC ACCTCAATTG TAGAAAAGCC CAGAGCAAGT 5461 GGAAGGAAAA GGGGTATCCC CAGGAAAACA GACATGTCCT CTTAATCTTC TGAGCATCAG 5521 GGCTACCCAT TACTTTGTGA CTTTCTCACT CTGTGACCAT GCTCAAGAGC TATGGAGAAA 5581 TCTAAAACAG GAACCTGGAC AGTGGGTCCT ACACAGAGAC AGAGGAGAGT GGGCCAGGGC 5641 AAGGTGGGAG TGGGAGAAGT CTGAGATGAA AACATCAGAA TGGAGCAGAG GCAAGAATGA 5701 GATTTCACCT GGGAGGTTAT GGGTGGGGAA AGATACGAAA TACAGGAGAC AGGAGAGGGA 5761 AGATGGGCGG AACACAGGGT GAGAATGAGA TTCCAGGGAA GCCTAGCTCA GCTTTAACCC 5821 AATTTGTCCA TTCATTGGAG AGAGTATCTA TGGCCGTGTT CAAACCCTGG GGTGCTCTGT 5881 TCCAGGGGAG ATCATCGGGG GCACAGAATG CAAGCCACAT TCCCGCCCCT ACATGGCCTA 5941 CCTGGAAATT GTAACTTCCA ACGGTCCCTC AAAATTTTGT GGTGGTTTCC TTATAAGACG 6001 GAACTTTGTG CTGACGGCTG CTCATTGTGC AGGAAGGTGA GACAACAGGG TCTATTTATC 6061 TCCAAATGGG AGATGAACAA CCAGAGTAGC ATCCAGGAAT ACACCTGCAC TGGGGACTGA 6121 AGAGGGGGTC CTGGGTCTTG TCAACTTTCA GGAGAGGGAA GACTTTGGGC TGAAAGACTT 6181 TAGTCTGTGT TTGAATAGTT CCTTGAGCCT CAGTCACTGA GCTAAGCTCC CTTCGGAGGA 6241 AAAGGAGGTC CTGTCCGAAG GTCCCTCTTG TTGCAGTAGC ACCCCTCACC CCTACCCAAC 6301 TCAAGACACA CGGCTCACTT TTCAGGGCCC CACCCAGTCT CAGGGCCACT TCCTCTATGG 6361 CCTTTTCAAG AACACTGGCT CTAGTTCTCA GGGTCCTGAA CCCATCATTT TATGGGAGCA 6421 GAGAACAGGT CTACATAAGA CCCCCACTTT CCCGTTTTAA CTGATATCTC CTGCTTCAGG 6481 GGCTGGCCCT CATGCAGGGT TCCCTGAATT AGGAAGTGTG AACCCTGTCC CCTGAGTCCT 6541 CCCTGGCCTG TTCAGTCCCC AGCAATTCCA GGGGTCGTAG AAATTGTGTC TGTTTCCTGA 6601 GAAAGCTCTT TCATGAGTTA AGCCTGAGCC CTCAAATGCC ACAAGTGGCC CATGAAAAGG 6661 GAGATGGGTA GAGTCCGGCN ACCCAGTGAC AGAGTTTAGT CCTCTTTTCT CAGAATGAGC 6721 TCACCTCAGA AGAAACCCCA AGCCATCACT GTCGCCTCCT TTTCCTTCCT TCTTCCTCAC 6781 AGCAGGTCTA TAACAGTCAC CCTTGGAGCC CATAACATAA CAGAGGAAGA AGACACATGG 6841 CAGAAGCTTG AGGTTATAAA GCAATTCCGT CATCCAAAAT ATAACACTTC TACTCTTCAC 6901 CACGATATCA TGTTACTAAA GGTGACAACA CCTCTCTTCT CCCTTTCCAC TTCCCATTCT 6961 CCTAAGCTTC TCCTTCAGGT CCTCATTGCC CTGAATTTTT CTTAGGACTT GGCTATAACA 7021 TGAAGCTACT CACCCTGTCC CTCCCTGATC ACCTCCAACT GTCCAGAGCC CATTTCGAGG 7081 ACTGACAGTC CTTCATTCCC TTCACAGTTG AAGGAGAAAG CCAGCCTGAC CCTGGCTGTG 7141 GGGACACTCC CCTTCCCATC ACAATTCAAC TTTGTCCCAC CTGGGAGAAT GTGCCGGGTG 7201 GCTGGCTGGG GAAGAACAGG TGTGTTGAAG CCGGGCTCAG ACACTCTGCA AGAGGTGAAG 7261 CTGAGACTCA TGGATCCCCA GGCCTGCAGC CACTTCAGAG ACTTTGACCA CAATCTTCAG 7321 CTGTGTGTGG GCAATCCCAG GAAGACAAAA TCTGCATTTA AGGTGATCCT CCAACTAGGT 7381 TTCCTCTCCA AAACTCACTG TTCAGGGACC TGAATGCTCT TAGAAGGAGA TGGGGTCAGC 7441 AGGTTGTCAG TCAGGTGACA GGGTGAGCAT CACAGGAATT GCTGTCCTCC CGTGGTCCAA 7501 GACAGCCTCT GACCATCCAT TCCAGTCTAC TGCACTGGGG GCATGGGGTG ACTGTGGAGA 7561 ATGTGGATGA CGGTCCCAAG AAAGGAAGAA GGGGCATCAG AACTAGATGT ATAAGTGAGG 7621 AGCTCCACCT CCTGGGTCTG ACTTTAGGTC TCACTGTGAC TCCAAGCTGG CTGGCAGACA 7681 GGAGTGGAGG ACTTCCCGGG CTCACCTTCT TCTCTCTCTC CTCCCCCTAC AGGGAGACTC 7741 TGGGGGCCCT CTTCTGTGTG CTGGGGTGGC CCAGGGCATC GTATCCTATG GACGGTCGGA 7801 TGCAAAGCCC CCTGCTGTCT TCACCCGAAT CTCCCATTAC CGGCCCTGGA TCAACCAGAT 7861 CCTGCAGGCA AATTAATCCT GGATCCTGAG CCAGCCTGAA GGGAAGCTGG AACTGGACCT 7921 TAGCAGCAAA GTGTGTGCAA CTCATTCTGG TTCTACCCTT GGTTCCCTCA GCCACAACCC 7981 TAAGCCTCCA AGAGGTCTCC TACAGGTAAC AGAACTTTCA ATAAACTTCA GTGAAGACAC 8041 AGCTTCTAGT CGTGAGTGTG TGTCCCTCTC TGCTGCTCTC TTCTCCTGCA CATGTGACCT 8101 GATTCCCAGC CCAAGCACCA AGGA (2) INFORMATION FOR SEQ ID NO:2468: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 661 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2468: 1 ATCATCGGGG GCACAGAATC CAAGCCACAT TCCCGCCCCT ACATGGCCTA CCTGGAAATT 61 GTAACTTCCA ACGGTCCCTC AAAATTTTGT GGTGGTTTCC TTATAAGACG GAACTTTGTG 121 CTGACGGCTG CTCATTGTGC AGGAAGGTCT ATAACAGTCA CCCTTGGAGC CCATAACATA WO 00/09525 PCTUS99/17712 EPI- 109 606 181 ACAGAGGAAG AAGACACATG GCAGAAGCTT GAGGTTATAA AGCAATTCCG TCATCCAAAA 241 TATAACACTT CTACTCTTCA CCACGATATC ATGTTACTAA AGTTGAAGGA GAAAGCCAGC 301 CTGACCCTGG CTGTGGGGAC ACTCCCCTTC CCATCACAAT TCAACTTTGT CCCACCTGGG 361 AGAATGTGCC GGGTGGCTGG CTGGGGAAGA ACAGGTGTGT TGAAGCCGGG CTCAGACACT 421 CTGCAAGAGG TGAAGCTGAG ACTCATGGAT CCCCAGGCCT GCAGCCACTT CAGAGACTTT 481 GACCACAATC TTCAGCTGTG TGTGGGCAAT CCCAGGAAGA CAAAATCTGC ATTTAAGGGA 541 GACTCTGGGG GCCCTCTTCT GTGTGCTGGG GTGGCCCAGG GCATCGTATC CTATGGACGG 601 TCGGATGCAA AGCCCCCTGC TGTCTTCACC CGAATCTCCC ATTACCGGCC CTGGATCAAC 661 CAGATCCTGC AGGCAAATTA A (2) INFORMATION FOR SEQ ID NO:2469: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1261 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2469: 1 GCCACCATGG AAACCCTTTG CCTCAGGGCA TCCTTTTGGC TGGCACTGGT TGGATGTGTA 61 ATCAGTGATA ATCCTGAGAG ATACAGCACA AATCTAAGCA ATCATGTGGA TGATTTCACC 121 ACTTTTCGTG GCACAGAGCT CAGCTTCCTG GTTACCACTC ATCAACCCAC TAATTTGGTC 181 CTACCCAGCA ATGGCTCAAT GCACAACTAT TGCCCACAGC AGACTAAAAT TACTTCAGCT 241 TTCAAATACA TTAACACTGT GATATCTTGT ACTATTTTCA TCGTGGGAAT GGTGGGGAAT 301 GCAACTCTGC TCAGGATCAT TTACCAGAAC AAATGTATGA GGAATGGCCC CAACGCGCTG 361 ATAGCCAGTC TTGCCCTTGG AGACCTTATC TATGTGGTCA TTGATCTCCC TATCAATGTA 421 TTTAAGCTGC TGGCTGGGCG CTGGCCTTTT GATCACAATG ACTTTGGCGT ATTTCTTTGC 481 AAGCTGTTCC CCTTTTTGCA GAAGTCCTCG GTGGGGATCA CCGTCCTCAA CCTCTGCGCT 541 CTTAGTGTTG ACAGGTACAG AGCAGTTGCC TCCTGGAGTC GTGTTCAGGG AATTGGGATT 601 CCTTTGGTAA CTGCCATTGA AATTGCCTCC ATCTGGATCC TGTCCTTTAT CCTGGCCATT 661 CCTGAAGCGA TTGGCTTCGT CATGGTACCC TTTGAATATA GGGGTGGACA GCATAAAACC 721 TGTATGCTCA ATGCCACATC AAAATTCATG GAGTTCTACC AAGATGTAAA GGACTGGTGG 781 CTCTTCGGGT TCTATTTCTG TATGCCCTTG GTGTGCACTG CGATCTTCTA CACCCTCATG 841 ACTGGTGAGA TGTTGAACAG AAGGAATGGC AGCTTGAGAA TTGCCCTCAG TGAACATCTT 901 AAGCAGCGTC GAGAAGTGGC AAAAACAGTT TTCTGCTTGG TTGTAATTTT TGCTCTTTGC 961 TGGTTCCCTC TTCATTTAAG CCGTATATTG AAGAAAACTG TGTATAACGA GATGGACAAG 1021 AACCGATGTG AATTACTTAG TTTCTTACTG CTCATGGATT ACATCGGTAT TAACTTGGCA 1081 ACCATGAATT CATGTATAAA CCCCATAGCT CTGTATTTTG TGAGCAAGAA ATTTAAAAAT 1141 TGTTTCCAGT CATGCCTCTG CTGCTGCTGT TACCAGTCCA AAAGTCTGAT GACCTCGGTC 1201 CCCATGAACG GAACAAGCAT CCAGTGGAAG AACCACGATC AAAACAACCA CAACACAGAC 1261 CGGAGCAGCC ATAAGGACAG CATGAACTGA CCACCCTTAG AAGCACTCCT (2) INFORMATION FOR SEQ ID NO:2470: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1861 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2470: 1 GAATTCGGGA AAAAGTGAAG GTGTAAAAGC AGCACAAGTG CAATAAGAGA TATTTCCTCA 61 AATTTGCCTC AAGATGGAAA CCCTTTGCCT CAGGGCATCC TTTTGGCTGG CACTGGTTGG 121 ATGTGTAATC AGTGATAATC CTGAGAGATA CAGCACAAAT CTAAGCAATC ATGTGGATGA 181 TTTCACCACT TTTCGTGGCA CAGAGCTCAG CTTCCTGGTT ACCACTCATC AACCCACTAA 241 TTTGGTCCTA CCCAGCAATG GCTCAATGCA CAACTATTGC CCACAGCAGA CTAAAATTAC 301 TTCAGCTTTC AAATACATTA ACACTGTGAT ATCTTGTACT ATTTTCATCG TGGGAATGGT 361 GGGGAATGCA ACTCTGCTCA GGATCATTTA CCAGAACAAA TGTATGAGGA ATGGCCCCAA 421 CGCGCTGATA GCCAGTCTTG CCCTTGGAGA CCTTATCTAT GTGGTCATTG ATCTCCCTAT 481 CAATGTATTT AAGCTGCTGG CTGGGCGCTG GCCTTTTGAT CACAATGACT TTGGCGTATT 541 TCTTTGCAAG CTGTTCCCCT TTTTGCAGAA GTCCTCGGTG GGGATCACCG TCCTCAACCT 601 CTGCGCTCTT AGTGTTGACA GGTACAGAGC AGTTGCCTCC TGGAGTCGTG TTCAGGGAAT 661 TGGGATTCCT TTGGTAACTG CCATTGAAAT TGTCTCCATC TGGATCCTGT CCTTTATCCT 721 GGCCATTCCT GAAGCGATTG GCTTCGTCAT GGTACCCTTT GAATATAGGG GTGAACAGCA 781 TAAAACCTGT ATGCTCAATG CCACATCAAA ATTCATGGAG TTCTACCAAG ATGTAAAGGA 841 CTGGTGGCTC TTCGGGTTCT ATTTCTGTAT GCCCTTGGTG TGCACTGCGA TCTTCTACAC 901 CCTCATGACT TGTGAGATGT TGAACAGAAG GAATGGCAGC TTGAGAATTG CCCTCAGTGA 961 ACATCTTAAG CAGCGTCGAG AAGTGGCAAA AACAGTTTTC TGCTTGGTTG TAATTTTTGC 1021 TCTTTGCTGG TTCCCTCTTC ATTTAAGCCG TATATTGAAG AAAACTGTGT ATAACGAGAT 1081 GGACAAGAAC CGATGTGAAT TACTTAGTTT CTTACTGCTC ATGGATTACA TCGGTATTAA 1141 CTTGGCAACC ATGAATTCAT GTATAAACCC CATAGCTCTG TATTTTGTGA GCAAGAAATT 1201 TAAAAATTGT TTCCAGTCAT GCCTCTGCTG CTGCTGTTAC CAGTCCAAAA GTCTGATGAC 1261 CTCGGTCCCC ATGAACGGAA CAAGCATCCA GTGGAAGAAC CACGATCAAA ACAACCACA WO 00/09525 PCTIUS99/17712 EPI-109 607 1321 CACAGACCGG AGCAGCCATA AGGACAGCAT GAACTGACCA CCCTTAGAAG CACTCCTCGG 1381 TACTCCCATA ATCCTCTCGG AGAAAAAAAT CACAAGGCAA CTGTGAGTCC GGGAATCTCT 1441 TCTCTGATCC TTCTTCCTTA ATTCACTCCC ACACCCAAGA AGAAATGCTT TCCAAAACCG 1501 CAAGGGTAGA CTGGTTTATC CACCCACAAC ATCTACGAAT CGTACTTCTT TAATTGATCT 1561 AATTTACATA TTCTGCGTGT TGTATTCAGC ACTAAAAAAT GGTGGGAGCT GGGGGAGAAT 1621 GAAGACTGTT AAATGAAACC AGAAGGATAT TTACTACTTT TGCATGAAAA TAGAGCTTTC 1681 AAGTACATGG CTAGCTTTTA TGGCAGTTCT GGTGAATGTT CAATGGGAAC TGGTCACCAT 1741 GAAACTTTAG AGATTAACGA CAAGATTTTC TACTTTTTTT AAGTGATTTT TTTGTCCTTC 1801 AGCCAAACAC AATATGGGCT CAAGTCACTT TTATTTGAAA TGTCATTTGG TGCCAGTATC 1861 CCGAATTC (2) INFORMATION FOR SEQ ID NO:2471: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 2581 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2471: TACCAGTCCA AAAGTCTGAT GACCTCGGTC CCCATGAACG GAACAAGCAT CCAGTGGAAG AACCACGATC AAAACAACCA CAACACAGAC CGGAGCAGCC ATAAGGACAG CATGAACTGA CCACCCTTAG AAGCACTCCT GAATTCGGGA AAAAGTGAAG GTGTAAAAGC AGCACAAGTG CAATAAGAGA TATTTCCTCA AATTTGCCTC AAGATGGAAA CCCTTTGCCT CAGGGCATCC TTTTGGCTGG CACTGGTTGG ATGTGTAATC AGTGATAATC CTGAGAGATA CAGCACAAAT CTAAGCAATC ATGTGGATGA TTTCACCACT TTTCGTGGCA CAGAGCTCAG CTTCCTGGTT ACCACTCATC AACCQACTAA TTTGGTCCTA CCCAGCAATG GCTCAATGCA CAACTATTGC CCACAGCAGA CTAAAATTAC TTCAGCTTTC AAATACATTA ACACTGTGAT ATCTTGTACT ATTTTCATCG TGGGAATGGT GGGGAATGCA ACTCTGCTCA GGATCATTTA CCAGAACAAA TGTATGAGGA ATGGCCCCAA CGCGCTGATA GCCAGTCTTG CCCTTGGAGA CCTTATCTAT GTGGTCATTG ATCTCCCTAT CAATGTATTT AAGCTGCTGG CTGGGCGCTG GCCTTTTGAT CACAATGACT TTGGCGTATT TCTTTGCAAG CTGTTCCCCT TTTTGCAGAA GTCCTCGGTG GGGATCACCG TCCTCAACCT CTGCGCTCTT AGTGTTGACA GGTACAGAGC AGTTGCCTCC TGGAGTCGTG TTCAGGGAAT TGGGATTCCT TTGGTAACTG CCATTGAAAT TGTCTCCATC TGGATCCTGT CCTTTATCCT GGCCATTCCT GAAGCGATTG GCTTCGTCAT GGTACCCTTT GAATATAGGG GTGAACAGCA TAAAACCTGT ATGCTCAATG CCACATCAAA ATTCATGGAG TTCTACCAAG ATGTAAAGGA CTGGTGGCTC TTCGGGTTCT ATTTCTGTAT GCCCTTGGTG TGCACTGCGA TCTTCTACAC CCTCATGACT TGTGAGATGT TGAACAGAAG GAATGGCAGC TTGAGAATTG CCCTCAGTGA ACATCTTAAG CAGCGTCGAG AAGTGGCAAA AACAGTTTTC TGCTTGGTTG TAATTTTTGC TCTTTGCTGG TTCCCTCTTC ATTTAAGCCG TATATTGAAG AAAACTGTGT ATAACGAGAT GGACAAGAAC CGATGTGAAT TACTTAGTTT CTTACTGCTC ATGGATTACA TCGGTATTAA CTTGGCAACC ATGAATTCAT GTATAAACCC CATAGCTCTG TATTTTGTGA GCAAGAAATT TAAAAATTGT TTCCAGTCAT GCCTCTGCTG CTGCTGTTAC CAGTCCAAAA GTCTGATGAC CTCGGTCCCC ATGAACGGAA CAAGCATCCA GTGGAAGAAC CACGATCAAA ACAACCACAA CACAGACCGG AGCAGCCATA AGGACAGCAT GAACTGACCA CCCTTAGAAG CACTCCTCGG TACTCCCATA ATCCTCTCGG AGAAAAAAAT CACAAGGCAA CTGTGAGTCC GGGAATCTCT TCTCTGATCC TTCTTCCTTA ATTCACTCCC ACACCCAAGA AGAAATGCTT TCCAAAACCG CAAGGGTAGA CTGGTTTATC CACCCACAAC ATCTACGAAT CGTACTTCTT TAATTGATCT AATTTACATA TTCTGCGTGT TGTATTCAGC ACTAAAAAAT GGTGGGAGCT GGGGGAGAAT GAAGACTGTT AAATGAAACC AGAAGGATAT TTACTACTTT TGCATGAAAA TAGAGCTTTC AAGTACATGG CTAGCTTTTA TGGCAGTTCT GGTGAATGTT CAATGGGAAC TGGTCACCAT GAAACTTTAG AGATTAACGA CAAGATTTTC TACTTTTTTT AAGTGATTTT TTTGTCCTTC AGCCAAACAC AATATGGGCT CAAGTCACTT TTATTTGAAA TGTCATTTGG TGCCAGTATC CCGAATTC (2) INFORMATION FOR SEQ ID NO:2472: (C) SEQUENCE CHARACTERISTICS: (A) LENGTH: 361 base pairs (B) TYPE: nucleic acid (C) STRJA1DEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2472: 1 GCTCAGCCTC CAAAGGAGCC AGCCTCTCCC CAGTTCCTGA AATCCTGAGT GTTGCCTGCC 61 AGTCGCCATG AGAACTTCCT ACCTTCTGCT GTTTACTCTC TGCTTACTTT TGTCTGAGAT 121 GGCCTCAGGT GGTAACTTTC TCACAGGCCT TGGCCACAGA TCTGATCATT ACAATTGCGT 181 CAGCAGTGGA GGGCAATGTC TCTATTCTGC CTGCCCGATC TTTACCAAAA TTCAAGGCAC 241 CTGTTACAGA GGGAAGGCCA AGTGCTGCAA GTGAGCTGGG AGTGACCAGA AGAAATGACG 301 CAGAAGTGAA ATGAACTTTT TATAAGCATT CTTTTAATAA AGGAAAATTG CTTTTGAAGT 361 AT (2) INFORMATION FOR SEQ ID NO:2473: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 4621 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear )xi)SEQUENCE DESCRIPTION: SEQ ID NO:2473: WO 00/09525 PCTIUS99/17712 EPI-109 608 1 ATCCTTTAAG TCAATGGACT TTGCATCAGT CACACCATCT TTTGTTACTT TGGACTTCCC 61 CAGCTATGTT CAATAATTAC TGTTCTTCCC TTGGGCCCCA TTGTAATGGC TACAGCCTCG 121 ACAAAAAGTC TACACTTTGA AGCATTAAGG CTCGGACATC AGCACCAAAT TTTACATCTT 181 TACCATCACT TCAAGTGAGG TGAGGAGCCA GTAGCCTGGA CACTGGTCTC ATCTGGTGAA 241 AGACTGTGGG TAATGGAAGC ATTTCTGTGG GGTGCTGGCA GGACATGTGC ATGGCGAGGC 301 AGGTCATCAG CAGCAAGTGA GAGCTGCCTC TTACTTTCTA AAGGTGACAT AGCAAATATA 361 CAAAAAAAAA TAAATAAATT ATTAATTTAG GTAGAGCACA TAAAGGCTTT ATTTCATATT 421 CCATTTCTCT GTATGCTTTC TTCACCAGGA AGAAATAGTT TTAGTGTCAG GAATGAATGA 481 GTCTGCCCCT CAATTCCAGC CTGCTCAACA CACAAGGAAA CAAAGCCCTG ACAATCAGAG 541 TGACTCCCTG GTGACTAAGC TCCCAGTCCT GGATGCATAT TTGTTTAGCA GTTCTGACAG 601 CATTTGACCC AGCCCTCTCT CTGCATATCC CATCAGAACC TTCTTTTTTT TTTTTTTCTT 661 TGAGACTGAG TCTTGCTCTG TCGGAAGCGA CTCCTGTGCC TCAGCCTCCC AAATACCTGG 721 AATTATAGGC GTAAGCCATC ATGCCTGGCT AATTTTTGTA TTTTTCATGG AGATGGGGTT 781 TTGCCATGTT GGTCAAATTG GTCTCACACT CCTGACCTCA TGTGATCCAC CTGCCTCAGC 841 CTCCCAAACT GCTGGGATGA CAGGTGTAAG CCACCATGCT AGGCTCAGAA ATTTCCTTTT 901 ATAAAAATGT CATTAAGGAT CTTGGCTGCA CAATATCGTT ACCAGCTTCC TTTAAATCCA 961 CTTCTGGCCT GCCAGGAATC AGGTTCTTCA GAACCTGACA TTTTAAATGA AGAGGTCAGG 1021 CAGTTCATGA GGAAAGCCTC ATTGTCCCCA TGTCTCTGTC ACTGCTGCAC CCCTGAGACA 1081 TCACAGACAT GGACACTGGG GCCTGCTTGT TTCTCAAACT GCCCTTAGAT CGAAAGAGGG 1141 AGGAACCAGG ATGAATGCCA CTCATTTTCC CAAGAAAGGC CCTCTCCTGA GTGCCCGGGA 1201 TGGGGCTCTG TCCATTGCCT GGGGCCGCCA ATTGCTACTC TGGGTTACGG AGGAAGGACA 1261 GGGTCCTGAG AGACACCAGA GACCTCACAC AGCCCTGAAA ACATGGGGCT CCTTCATAAG 1321 TGTTTCCCAT CACCAACAGG GAGACCACGT GGAGGCCTTG CAGCCCCACT CGGTGCTTCT 1381 CCACCAAATC CCAAGGGCAG TGACGCTGAC GTCTGTGGAA AGCAGAGAAA GCCCTGGCTC 1441 CCAAAGCCCT GAAGTCCCTG TGGAGCTGAC ATTCCCTGAG TGACGGTGTG AATGGAAGGA 1501 ACTCAAGTGC GGGTGGTAGG CCACCTCCTG GCCCAGGCCT GGGTGAACTC TGAGGGGACA 1561 CATGTAGTCA CAATCCCATC CTCCCATTCT CCTTCTCAGA GGAAGGAAGT GGGCATCCAT 1621 CTGCCTCATC TCTCTCCCGT GGGGAAGATG GGGAGTTTCA GGGGAACTTT CACATAAATT 1681 TCACCAGCTC AGATCTCCTG TGAGGATGGG GCCCACCATG CTCCCGGTGC TGCCAGAGGC 1741 CCTGAGCCCC TCCCAGGGTC CCTGGGTTTG AGCCAGCCCT GTATCATCCC CAGGAGCTGA 1801 ATGTCAGAGC AATGGATAGA ATTAGATGGA AAGAGCTCTC AATTTGACCT GAGACTGTCC 1861 CCAGATACTC AGGAAAAACA GGACGTCGCA CAGAGTGGGC AGCAGGTGAG TGGCAGGTTA 1921 TAGGTCCTGA GTTTGAGTTT GTTCTCACGT GAGACAGACC CAGCCCCTCA CTCCATTCAC 1981 ACACTGGGTT TTAAATGGTG CAAGATAGGA GCAATTTTCT GGTCCCAAGA GCAGGAGGAA 2041 GGGATTTTCT GGGGTTTCCT GAGTCCAGAT TTGCATAAGA TCTCCTGAGT GTGCATTGTT 2101 CTTTGAGGAC CATTCTCTGA CTCACCAGGT AAGTGGCTGA ATTCTAACCT CTGTAATGAG 2161 CATTGCACCC AATACCAGTT CTGAACTCTA CCTGGTGACC AGGGACCAGG ACCTTTATAA 2221 GGTGGAAGGC TTGATGTCCT CCCCAGACTC AGCTCCTGGT GAAGCTCCCA GCCATCAGCC 2281 ATGAGGGTCT TGTATCTCCT CTTCTCGTTC CTCTTCATAT TCCTGATGCC TCTTCCAGGT 2341 GAGATGGGCC AGGGAAATAG GAGGGTTGGC CAAATGGAAG AATGGCGTAG AAGTTCTCTG 2401 TCTCCTCTCA TTCCCCTCCA CCTATCTCTC CCTCATCCCT CTCTCTCCTT CCTCTCTCTG 2461 TGTGTCCCCT CCATCCTTTT CTCCTGCTTC TCTCTCTTCT TCCCTCTCTC TCTTTTTTCT 2521 GTCTTTCTTT TTCCTCTCTC CCTAGAGCAT GTCTTTCTTT CTTTCTCTTT CCTTTCTTCT 2581 ACCCACACTT TTAGACTGAA TGCCCTATTT AATTGAACAA AGCATTGCTT CCTTCAATAG 2641 AAAAGGAGTT TGAGAACCCA ATGGACACCT CACTCGTTCT TCTAAGCCAA TATGAAGGAG 2701 CCCAGTAGCT TGTAAATATC ATCTCTTCAC TGCTTTCCAT GCTACAACTG CTGAGACTAT 2761 GGTTGAAACC TGTTAGGTGA CTTTTTAAAT AAAAGGCAGA AATTTTGATT TTATCTAAAG 2821 AAAGTAGTAT AGAATGTCAT TTTCTAAATT TTTATATTTA AAGGGTAGAT ACTGCAACCT 2881 AGAGAATTCC AGATAATCTT AAGGCCCAGC CTATACTGTG AGAACTACTG CAGCAAGACA 2941 CTCTGCCTCC AGGACTTTTC TGATCAGAGG CCCTGAGAAC AGTCCCTGCC ACTAGGCCAC 3001 TGCAGGTTCA CAGGACAGGG TACAGCCCAT TGAAACCTAC TTTTAAACCT GGATGCCTAA 3061 CCTTCATTTT CTCCTTGATA TTATGAAAAT AAAATAAAAA CCATGAAAGG ATAAAAGAGG 3121 GAGAGTGGAA GGGAAGGATG GAGAAAGGGA AAAAGAAAAT TTGAGAGTAA ATCCTAAAAC 3181 AATTAATCTA ATAGATATCA TCTTGTGAAA TCCTCATTTT ACCAATCTTA TTTATGAGTC 3241 CTGGGTTTTG TGAGAACAAT GGGGTTCTGA GAGGCACCAG AGACCTCATG TTTTCCAAAA 3301 CCTAGAACAG TATAATGAAG GAAGGCGGGG AGGCAGGGAG GCAGGGAGGC AGGGAGGCAG 3361 GGAGGCGGGC AGGTGGGGAG GGAGGGACGG AAGGAGGGAG GGAGGGAGGG AGGGAGGGAG 3421 GGAGGGATAA AAAAAGAAGA ATGAGGTTGA AACCAGGACT TAGATATTAG AAACAAGCCA 3481 TTACAAAATT TATTTCTATG GTTAATTGTG GTTTTCAACT GTAAGTTACT TGGTGTTAAT 3541 TTCCTATTAA ACAATTTCAG TAAGTTGCAT CTTTTTATCC CATCTCAGGT CAAATACTTA 3601 ACAGACTAAA TGATTTGAAA AAGCAAAAGT TTACTGGCTT GTGTGTGTTA AAATGGAGGT 3661 ATGGTGGCTT TGATATTATC TTCTTGTGGT GGAGCTGAAT TCACAAGAGA TCGTTGCTGA 3721 GCTCCTACCA GACCCCACCT GGAGGCCCCA GTCACTCAGG AGAGATCAGG GTCTTTCACA 3781 ATCAGGTTCT ACAAAAATAA ACATCCCCCC AACCACAGCA GTGCCAGTTT CCATGTCAGA 3841 AACTTAGATC CAAATGACTG ACTCGCGTCT CATTATCATG ATGGAAAAGC CCAGGCTTGA 3901 GAAAGAAGCC CGCTGCGGAT TTACTCAAGG CGATACTGAC ACAGGGTTTG TGTTTTTCCA 3961 ACATGAGTTT TGAGTTCTTA CACGCTGTTT GCTCTTTTTG TGTGTTTTTT CCCTGTTAGG 4021 TGTTTTTGGT GGTATAGGCG ATCCTGTTAC CTGCCTTAAG AGTGGAGCCA TATGTCATCC WO 00/09525 PCT/US99/17712 EPI-109 609 4081 AGTCTTTTGC CCTAGAAGGT ATAAACAAAT TGGCACCTGT GGTCTCCCTG GAACAAAATG 4141 CTGCAAAAAG CCATGAGGAG GCCAAGAAGC TGCTGTGGCT GATGCGGATT CAGAAAGGGC 4201 TCCCTCATCA GAGACGTGCG ACATGTAAAC CAAATTAAAC TATGGTGTCC AAAGATACGC 4261 AATCTTTATC CTAGTAATTG TGGTCATTGG GTGATGTTGG TTTGGGCAGG CCATCTCTAA 4321 TATCCTTGAA ACACCTTTTT CTGCTCTCCA GGAAGGGGTC AGGGCTGCCA CAGCGGGGCT 4381 TGGAGTGCTT TCCAGGGTCA CAGGCATCTG TATTCTTTGG ATTCCTTGAC CTTCCCCATT 4441 TATTCCCGGC ATTTTCCTAA AACGTGTGCT TTGCTCCTCC TGCATCCTCC CCTTGCATGC 4501 CCTCACCTAC CCCACATCTT CCCTAAAAAA AGCAAGCCCA ACTCAAAGAC CAGTTCCCTC 4561 ATGGAATCAT AGTGGATCTG CCAAGGGAGG GGATGCCCAG TCCTCTGTTC TTCACAAGAC 4621 TCCCTTCTTC TGGCTAAGGT TTCTTATGCA ATTAT (2) INFORMATION FOR SEQ ID NO:2474: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1981 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2474: 1 CTGCAGTGGT AAAAAGATTC TATATCTGCT GTTTGATGAA TGCAGCACCC ACTAGCCACA 61 TAGTGCTCGT GAGCACTTGC AATGCGGCTA GGGTGATTTC AATTAACCTA AAAGAGAACA 121 GCCACAGGGA GCATGTGGCT GCCATATTGG ATGGTGCTGC TTTGAGAACA AAATGAGAGA 181 AATGAAGCCT CTATTTACCT TGGTTGGCGG AACACATTGA AGGGACTCTG TATTGATACC 241 AGGCTTCAAA CTTTGGGAAG TGTACTGGCC AACTTAAACA CATCCACAGG AGAATGAAGA 301 GGTTTGGGAA GGGACCAGAA ACCAGGCATT GAGGACAATG AGAAGAGTTT TTCAAAAGTG 361 GAATTACTGC AAAAAGTGGA AAAATAGCCT TTGGATGGAA GTTACTGATG AGACAATTTC 421 CATCGGTGTG AAAGCCATCT TTCCAACAGA GATCTGCAAC ATGAGAATGT ACTGTCTCCT 481 AGGGTAGCGA TGGCCTCTTG TATTAGTCCG CTCAGGCTAC CAGATTTATC GTTTAAACTG 541 CCCATAAACA GACCAGGCAG TTTAAACAAC AGAAATTTAT TTCCTCGCAG TCCTGGAGGC 601 AGGAAGTCTG CGATCAAGGT GGAAGCAGGG TTGGCTTCTT CTCAGGTGTC TGTCCTTGGC 661 TGGTAGATGA CCGCCGCCTC CCTGGGTCCT CACATGGTCT TTCCTCTGTG TGTGTCTGTC 721 CCAATCTCTT CTTATAAGGA TGCAAGTCTT ATGGATCAGA GCACACCCCA ATGACCGTGT 781 TTAACTTGAA TCACCTCTTT AAAGTTTCTC TCTCCAAATA CAATCACCTC CTGAGGCACT 841 GTTAGGGCTT CGACACAGGA ATTCTTTTCC TAGGGGATTC AGTTCAGTCC AAAACGCCTA 901 CCAGTGGAGA CTTGCAACAT GGCGGCCTGC TGGTCCCTCG CCAGGAATAT CACAGGCGAC 961 TGTTCCCTGT TGCATGGAAT AGAAGGCTAT TCCAGAGTAC TGTCTCTATT TATCAGATCT 1021 GGGATACTGG GAGAAGGGCA AAATAAAGTC CAAGTAGAAA AAAAAACTAT GAAAGTTTTA 1081 GAGAGTAACC ATAATTTCAG CCCGATGTGA AACGATCCTA GATTTCAGCT GAAATAGTGA 1141 TGTGGGAAGT GAGGGGGCCG GGATTCAAGG CAGAGGGAAC AGCGTAACTG AAGGCATGGA 1201 AGGAGGGAAG TGTAGGCTGT GTTTGAAGAG TGGCAGCTGC TTCCACATTT CTAAAACACA 1261 GGATGTGATT TTGGGGTGTG TTGAGACAAG GCAGAAAACT TGTTTGGAAA AATAACTTGA 1321 ATTCCCTGCA CATTTAAAAT CTCTCAGCAG AAGAAAACCC CACTCAGAAC CCCACTGTTC 1381 ATTCCTTGGC TTGTATTTGG SCACAGCTGG CATAGCCCCA GACTGAGTAA GCTCTTCAGA 1441 CACCTCATTT CATGAGTAGC CCCAAAGATC AATCATGGGC CAATTTCTTG GAAGAGAAGA 1501 CTCTCCGGTG TTTTGCAGTT ATTTGTTCTG CTTTCGCGAG ATGTTCTCAA ATCGTTGCAG 1561 CTACAAGCCA TGAGTCTGAA GTGTTTGTGT TCCCTCCTTA CAGGTGGTAA CTTTCTCACA 1621 GGCCTTGGCC ACAGATCTGA TCATTACAAT TGCGTCAGCA GTGGAGGGCA ATGTCTCTAT 1681 TCTGCCTGCC CGATCTTTAC CAAAATTCAA GGCACCTGTT ACAGAGGGAA GGCCAAGTGC 1741 TGCAAGTGAG CTGAGAGTGA CCAGAAGAAA TGACGCAGAA GTGAAATGAA CTTTTTATAA 1801 GCATTCTTTT AATAAAGGAA AATTGCTTTT GAAGTATACC TCCTTTGGGC CAAAATGAAT 1861 CTTGTGTCTC AATTGGAAGA GGTAAAGAAG TAGGGGGTTA GGGTGCATGG GTTGGAACGT 1921 GAGACAGGTC GAACCACAAA GCCTGCCTGG AAAAGGGGAG TGACGTCCTA GGCTTCAGTG 1981 ATGTCACCTC CACTTTGTTT GATCCACAAA CCAACAGGTG ACTGATTTTG (2) INFORMATION FOR SEQ ID NO:2475: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 301 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2475: 1 GTCAGCTCAG CCTCCAAAGG AGCCAGCCTC TCCCCAGTTC CTGAAATCCT GAGTGTTGCC 61 TGCCAGTCGC CATGAGAACT TCCTACCTTC TGCTGTTTAC TCTCTGCTTA CTTTTGTCTG 121 AGATGGCCTC AGGTGGTAAC TTTCTCACAG GCCTTGGCCA CAGATCTGAT CATTACAATT 181 GCGTCAGCAG TGGAGGGCAA TGTCTCTATT CTGCCTGCCC GATCTTTACC AAAATTCAAG 241 GCACCTGTTA CAGAGGGAAG GCCAAGTGCT GCAAGTGAGC TGGGAGTGAC CAGAAGAAAT 301 GACGCAGAAG TGAAATGAAC TT (2) INFORMATION FOR SEQ ID NO:2476: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 4741 base pairs WO 00/09525 PCT/US99/17712 EPI-109 610 (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2476: 1 GAATTCACAT TTCTCACCTT TTGATGTATT AAGAAAGTAT GGAGAAATAT ATCCTCTATC 61 AAATTTTCAT GCCTTCAATA ATTTCTAATT CATCAGTCAG TGTTTTTCCA TCCTTTACTG 121 TGATGATGCC CTTTCTTCCA AACTTTTTCA TTGCATCAGA GATGATGTTA CCAATTTCTT 181 TGTCTCCATT TGCAGAAATT GTAGCAACCT GTGCAATTTC TTCAGGTTTG GTCACAGGTT 241 TAGACTGCTT TTTAAGTTCA GCAATTACAG CATCAACAGC TAACATCACA CCTCTCTTGA 301 TTTCCACTGG ATTAGCACCT TTGCTAACCT TCTGGAAGGC TTATTTGGAA ATAGAGCATA 361 CCAGTACAGC AGCAGTGATA GTGCCATCCC CCAGTCTCTC CATTTGTGTT ATTGGCAACA 421 TCTTGGACAA GTTTAGCTCC AATGCTTTTA TATTTATCCT TTAAGTCAAT TGACTTTGCA 481 TCAGTCACAC CATCTTTTGT TACTTTGGGA CTTCCCCAGC TATGTTCAAT AATTACTGTT 541 CTTCCCTTTG GCCCCATTGT AATGGCTACA GCATCGACAA AAAGTCTACA CTTTGAAGCA 601 TTAAGGCTCA GACATCAGCA CCAAATTTTA CATCTTTACC ATCACTTCAA GTGAGGTGAG 661 GAGCCAGTAG CCTGGACACT GGTCTCATCT GGTGAAAGAC TGTGGGTAAT GGAAGCATTT 721 CTGTGGGGTG GTGGCAGGAC ATGTGCATGG TGAGGCAGGT CATCAGCAGC AAGTGAGAGC 781 TGCCTCTTAC TTTCTAAAGG TGACATAGCA AGTATACAAA AAAAAATAAA ATATTAATTT 841 AGGCAGAGCA CATAAAGGCT TTATTTCATA TTCCATTTCT CTGTATGCTT TCTTCACCAG 901 GAAGAAATAG TTTTAGTGTC AGGAATGAAT GAGTCTGCCC CTCAATTCCA GCCTGCTCAG 961 CACACAAGGA AACAAAGCCC TGACAATCAG AGTGACTCCC TGGTGACTAA GCTCCAGTCC 1021 TGGATGCATA TTTGTTTAGC AGTTCTGACA GCATCTGACC CAGCCCTCTC TTTGCATACC 1081 CCACCAGAAC CTTCTTTTTT TTTTTTTTTC TTTGAGACTG AGTCTTGCTC TGTCGGAAGC 1141 GATTCCCGTG CCTCAGCCTC CCAAATACCT GGAATTATAG GCGTAAGCCA TCATGCCTGG 1201 CTAATTTTTG TATTTTTCAT GGAGATGGGG TTTTGCCATG TTGGTCAAAT TGGTCTCACA 1261 CTCCTGACCT CATGTGATCC ACCTGCCTCA GCCTCCCAAA GTGCTGGGAT GACAGGTGTA 1321 AGCCACCATG CTAGGCTCAG AAATTTCCTT TTATAAAAAT GTCATTAAGG ATCTTGGCTG 1381 CACAATATCG TTACCAGCTT CCTTTAAATC CACCTCTGGC CTGCCAGGAA TCAGGGTTCT 1441 TCAGAACCTG ACATTTTAAA TGAAGAGGTC AGGCAGGTCA TGAGGAAAGC CTCATTGTCC 1501 CCATGTCTCT GTCACTGCTG CACCCCTGAG ACATCACAGA CATGGACACT GGGGCCTGCT 1561 TGTTTCTCAA ACTGCCCTTA GATCGAAAGA GGGAGGAACC AGGATGAATG CCACTCATTT 1621 TCCCAAGAAA GGCCCTCTCC TGAGTGCCCG GGATGGGGCT CTGTCCATTG CCTGGGGCCG 1681 CCAATTGCTA CTCTGGGTTA CGGAAGAAGG ACAGGGTCCT GAGAGACACC AGAGACCTCA 1741 CACAGCCCTG AAAACATGGG GCTCCTTCAT AAGTGTTTCC CATCACCAAC AGGGAGACCA 1801 CGTGGAGGCC TTGCAGCCCT ACTCGGTGCT TCTCCACCAA ATCCCAAGGG CAGTGACGCT 1861 GACGTCTGTG GAAAGCAGAG AAAGCCCTGG CTCCCAAAGC CCTGAAGTCC TGTGGAGCTG 1921 ACATTCCCTG AGTGACGGTG TGAATGGAAG GAACTCAAGT GCGGGTGGTA GGCCACCTCC 1981 TGGCCCAGGC CTGGGTGAAC TCTGAGGGGA CACATGTAGT CACAATCCCA TCCTCCCATT 2041 CTCCTTCTCA GAGGAAGGAA GTGGGCATCC ATCTGCCTCA TCTCTCTCCC GTGGGGAAGA 2101 TGGGGAGTTT CAGGGGAACT TTCACATAAA TTTCACCAGC TCAGATCTCC TGTGAGGATG 2161 GGGCCCACCA TGCTCCCGGT GCTGCCAGAG GCCCTGAGCC CCTCCAGGGT CCCTGGGTTT 2221 GAGCCAGCCC TGTATCATCC CCAGGAGCTG AATGTCCGAA CAATGGATAG AATTAGATGG 2281 AAAGAGCTCT CAATTTGGCC TGAGACTGTC CCCAGATACT CAGGAAAAAC AGGACGTCGC 2341 ACAGAGTGGG CAGCAGGTGA GTGGCAGGTT ATAGGTCCTG AGTTTGAGTT TGTTCTCACG 2401 TGAGACAGAC CCAGCCCCTC ACTCCATTCA CACACTGGGT TTTAAATGGT GCAAGATAGG 2461 AGGAATTTTC TGGTCCCAAG AGCAGGAGGA AGGGATTTTC TGGGGTTTCC TGAGTCCAGA 2521 TTTGCATAAG ATCTCCTGAG TGTGCATTGT TCTTTGAGGA CCATTCTCTG ACTCACCAGG 2581 TAAGTGGCTG AATTCTAACC TCTGTAATGA GCATTGCACC CAATACCAGT TCTGAACTCT 2641 ACCTGGTGAC CAGGGACCAG GACCTTTATA AGGTGGAAGG CTTGATGTCC TCCCCAGACT 2701 CAGCTCCTGG TGAAGCTCCC AGCCATCAGC CATGAGGGTC TTGTATCTCC TCTTCTCGTT 2761 CCTCTTCATA TTCCTGATGC CTCTTCCAGG TGAGATGGGC CAGGGAAATA GGAGGGTTGG 2821 CCAAATGGAA GAATGGCGTA GAAGTTCTCT GTCTCCTCTC ATTCCCCTCC ACCTATCTCT 2881 CCCTCATCCC TCTCTCTCCT TCCTCTCTCT GTGTGTCCCC TCCATCCTTT TCTCCTGCTT 2941 CTCTCTCTTC TTCCCTCTCT CTCTTTTTTT CTGTCTTTCT TTTTCCTCTC TCCCTAGAGC 3001 ATGTCTTTCT TTCTTTCTCT TTCCTTTCTT CTACCCACAC TTTTAGACTG AGTAGACTGA 3061 ATGCCCTATT TAATTGAACC AAGCATTGCT TCCTTCAATA GAAAAGGAGT TTGAGAACCC 3121 AATGGACAAC TCACTCGTTC TTCTAAGCCA ATATGAAGGA GCCCAGTAGT TTGTAAATAT 3181 CATCTCTTCA CTGCTTTCCA TGCTACAACT GCTGAGACTA TGGTTGAAAC CTGTTAGGTG 3241 ACTTTTTAAA TAAAAGGCAG AAATTTTGAT TTTATCTAAA GAAAGTAGTA TAGAATGTCA 3301 TTTTCTAAAT TTTTATATTT AAAGAGTAGA TACTGCAACC TAGAGAATTC CAGATAATCT 3361 TAAGGCCCAG CCTATACTGT GAGAACTACT GCAGCAGACA CTCTGCCCCC AGGACTTTTC 3421 TGATCAGAGG CCCTGAGAAC AGTCCCTGCC ACTAGGCCAC TGCAGGTTCA CAGGACAGGG 3481 ACAGCCCATT GAAACCAACT TTTAAACCTG GATGCCTAAC CTTCATTTTC TCCTTGATAT 3541 TATGAAAATA AAATAAAAAC CATGAAAGGA TAAAAGAGGG AGAGTGGAAG GGAAGGATGG 3601 AGAAAGGGAA AAAGAAAATT TGAGAGTAAA TCCTAAAACA ATTAATCTAA TAGATATCAT 3661 CTTGTGAAAT CCTCATTTTA CCAATCTTAT TTATGAGTCC TGGGTTTTGT GAGAACAATG 3721 GGGTTCTGAG AGGCACCAGA GACCTCATAT TTTCCAAAAC CTAGAACAGT ATAATGAAGG 3781 AAGGAGGGAA GGAGGGAGGG AGGGAGGGAA GGAGGGAAGG AGGGAGGGAG GGAGGGAAAC 3841 AAAAAGAAGA ATGAGGTTGA AACCAGGACT TAGATATTAG AAACAAGCCA TTACAAAATT WO 00/09525 PCT/US99/17712 EPI-109 611 3901 TATTTCTATG GTTAATTGTG GTTTTCAACT GTAAGTTACT TGGTGTTAAT TTCCTATTAA 3961 ACAATTTCAG TAAGTTGCAT CTTTTTTATC CCATCTCAGA TCAAATACTT AACAGACTAA 4021 ATGATTTGAA AAAGCAAAAG TTTACTGGCT TGTGTGTGTT AAAATGGAGG TATGGTGGCT 4081 TTGATATTAT CTTCTTGTGG TGGAGCTGAA TTCACAAGAG ATCGTTGCTG AGCTCCTGCC 4141 AGACCCCACC TGGAGGCCCC AGTCACTCAG GAGAGATCAG GGTCTTTCAC AATCAGGTTC 4201 TACAAAAATA AACATCCCCC AAACCACAGC AGTGCCAGTT TCCATGTCAG AAACTTAGAT 4261 CCAAATGACT GACTCGCGTC TCATTATCAT GATGGAAAAG CCCAGGCTTG AGAAAGAAGC 4321 CCGCTGCGGA TTTACTCAAG GCGATACTGA CACAGGGTTT GTGTTTTTCC AACATGAGTT 4381 TTGAGTTCTT ACACGCTGTT TGCTCTTTTT GTGTGTTTTT TCCCTGTTAG GTGTTTTTGG 4441 TGGTATAGGC GATCCTGTTA CCTGCCTTAA GAGTGGAGCC ATATGTCATC CAGTCTTTTG 4501 CCCTAGAAGG TATAAACAAA TTGGCACCTG TGGTCTCCCT GGAACAAAAT GCTGCAAAAA 4561 GCCATGAGGA GGCCAAGAAG CTGCTGTGGC TGATGCGGAT TCAGAAAGGG CTCCCTCATC 4621 AGAGACGTGC GACATGTAAA CCAAATTAAA CTATGGTGTC CAAAGATACG CAATCTTTAT 4681 CCTAGTAATT GTGGTCATTG GGTGATGTTG GTTTGGGCAG GCCATCTCTA ATATCCTTGA 4741 AACACCTTTT TCTGCTCTCC AGGAAGGGGT CAGGGCTGCC ACAGCGGGGC TTGGAGTGC (2) INFORMATION FOR SEQ ID NO:2477: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 3661 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2477: 1 GAATTCCCTG TAAGCCCTGT TACAGGGGCT GCACCCCAGA TACAACCTGA CCTGTGTCCA 61 AGGCGGGCAA CTCAACCCTT AGATATTGAA TGGGTCCCAT GGCACCAATG CTTAAACACC 121 AGCAGCCCTC ACAACCACAG ATCGTGTTTT AAGGATGAGG AGGTAGTTCT CTGGATGCAC 181 AGGCTTCAAT CCAAATGGGC TCATGACGCC GCAGCACACA CCCAGTCTGC AGCCTGAAGA 241 GTTGGAGCAT TGCATTCACA GAAAGCATCC AGACATGATC ATGGGCTCAG GGATACACCT 301 GTTCTCCGAT GTGTACCAGT GAAGGATGGA AACTCCTATG CCTCCCAGAA AGCACCACTC 361 AAGCTTTTGC TGAATGCTTC TCTGAAGGCC CACAAGGCTG AGAGGCTGTG CAACACCAGC 421 AGTAAAGTGA ATGCCCAGAC TCCCACCTCC TTTCTTGGGT GGCCATCTGG AAAGGCCACT 481 CCCACCCTGA TGGCTAATGC CTCAGACCAG TTCTTGGCCC AGATGATCCT AGACAATTGT 541 TTAAGCTTAA ACTGTTCATT GGCCAAGCAA ACAGGTGATA GTACCTCTGG GGAACCACAT 601 GCCGCGTGTA CATCCAGATC TCAGGAGAAC CCAAAAATGT CTGTTCCACA TAGCAACAGA 661 AGCCCAGGTA GCACTCAGTC TCACCTGGGT GTTCTCCAAC ATCCCAGCTC AGCCAAATGG 721 CTTTCATTAG TTTTTATGGT TAGACCCCAG GTCCTCGGGA CACTGCTTTA GAAACACATT 781 CCAAATCCTC CTCTGTGTGC AGGTGGCATT CCTATCCCAA TCTCTTTGCA GGGCGTATAC 841 TGTGATACGC AGCCAGGCTG TCCCAGAGGC CTTAAATATT CCCTTGGTGC AGGTAGTTCA 901 GCTTAGCCAC AGCCAATGCA TCACAGGGTC AACTGTGTTA GGAGCCATTG AGAATCCATA 961 GTTGGTTGCT GCCTGGGCCT GGCCAGGGCT GACCAAGGTA GATGAGAGGT TCCTCTGTGG 1021 AGTTCTACTT TAACCTCACC TTCCCACCAA ATTTCTCAAC TGTCCTTGCC ACCACAATTA 1081 TTTAATGGAC CCAACAGAAA GTAACCCCGG AAATTAGGAC ACCTCATCCC AAAAGACCTT 1141 TAAATAGGGG AAGTCCACTT GTGCACGGCT GCTCCTTGCT ATAGAAGACC TGGGACAGAG 1201 GACTGCTGTC TGCCCTCTCT GGTCACCCTG CCTAGCTAGA GGATCTGTAA GTACTACAAA 1261 ACTTAAACTT TACACTGAGT TTTCATCATT GAAGCTATGC CTCCAATCTG ACCTCTGACT 1321 GTGGGGCCGC CCCAGAGGGA CCCAGCGGGT GAATCCCTGC TAGGAACGTC TGTCCGGACC 1381 TCTGGTGACT GCTGGGGACG ATGGCTTCCA GCTAACTTAA TAGAGAAACT CAAGCAGTTT 1441 CCTTCTAAAT ACACATGTCA CATGTCCTGG TTGACATGTC CAGTAAGAAG ACTATCACAG 1501 GTCTTTGGAA CATTCTTTTG AGAGAAACCT ATTTAGGTCC TTGGTCTGTT TTTCAATCAG 1561 GTTGTTTGAT TTTTGCTATT GAGTTGTTGG AATTCCTTAT GTATTCAGAT ATTTGCCCCT 1621 TCTGCCATGT AGGTTTTGCA AATATTTTCT CTCATTTTCT GGGTTATCTT TTCACTCGGT 1681 TGATTGTTTC CTTTGCTGTG CAGATGCTTT AGCGTTAAAT GAAGCCACAC TTGTCTATTT 1741 TCCCTTTTAT TGCCTGTGCC TTTGGTGTCA TAGCCAAGAA ATCATTACCT ACATCAATGT 1801 CAAAAGCTTT ATCCTTCTA.T ACACTTCTAG TAGTTTATGG TTTCAGTTGT TACATTTAGG 1861 TTTTCAATTC ATTCTGAGTT GATGTTCCTA CATGGTGTGA GATAAAGATT TAAATACATA 1921 CATATATAAA ATCATGAGGT AGTGTACACT ATAAATATAC AATTGTTAAT TGTTACTCAA 1981 GTCTAAGTAG AGGTGGAAAT AATAAACTTT CTTTTTTTTA CTTAAACCAC TCTGTGTCAC 2041 TGAGCTGATT TCACCTTTAG CCTGATAAAA TCATTGTCCT CTCCACCCTG ATTCCTACAG 2101 GAGACTACTC ACCCCATAAC CTCAAAAACC TCTTCATGAG GATGGTAAGT CACCTGAATC 2161 CTGAAGTGAA TTACTCGCTA TTCCATTGGA ACTCATATAG GACACCAGAA TCTAGACCTC 2221 CAGAGAACAG CAGGACCCAT CTTCAGAAAA TAAGAAGCAT TTGTTCCCTG AGCCTGTTGA 2281 ATCAAAGTGC AATTTCTATT CTTTTTGGAA TGTTAAAAAG TGAATCATAA TATTTAAGCA 2341 GGTGAACCCA CGAGTAACAT AGCAGGGTCT TTCTTGTCAT TATTAGCTCC AACCTAGCAC 2401 AGACATTAAA GGTACAGATG TATACTAGCA TGAAACTGGG AGAACAGGAG CATTCGAGCA 2461 ACCTTGAGAC CAATGGGCCT CTCTTATAAA ATGCACACCT CCTCTCACTG AGATTGAGGA 2521 AGGTTTCTTG TCTCCGAGCC TTCTCCCAGT AGAGCTATAA ATCCAGGCTG GCTCCTCCCT 2581 CCCCACACAG CTGCTCCTGC TCTCCCTCCT CCAGGTGACC CCAGCCATGA GGACCCTCGC 2641 CATCCTTGCT GCCATTCTCC TGGTGGCCCT GCAGGCCCAG GCTGAGCCAC TCCAGGCAAG 2701 AGCTGATGAG GTTGCTGCAG CCCCGGAGCA GATTGCAGCG GACATCCCAG AAGTGGTTGT WO 00/09525 PCT/US99/17712 EPI-109 612 2761 TTCCCTTGCA TGGGACGAAA GCTTGGCTCC AAAGCATCCA GGTGAGAGAG GCAGGCATGC 2821 AGAGCTGCTA AGTCTAGAGG GAAGGACGGG AGAGAGGTTC CAGAGTTGGG TCTCAGCAGT 2881 CTATGTCACT GAGGTGGCTT CACTTAGAAT CTCTGGGCAT TGATTTTCTC ATCTAGAAAT 2941 TGAACAGAGA GCCAAATAAA CCTGAGAAAC TTTATTTCTC CAAAGACTTG ATTCCAAGAA 3001 ACATCTGTGA AATTCACTAA GTTTAAGATA TGAAGAGACA GACTAGTTAT TTCTGGATCT 3061 AAACAAGTAG ACTTAGTTGT AAAGAGAACA TTTTACTCTA TCTACAGAAG AGCTTTTAAA 3121 AACTGCAGCC AAGCCTGAGG GTAAGTTCAG GTGTGTGTGT GATGGGGCAG GAATGCAAAA 3181 ATGAGAGCAA AGGAGAATGA GTCTCAAATT CTGTGTGACA AGCACTGCTC TGCGTGTTTA 3241 TTCCTATCGA CTGAGGTTGT TCGTGCTACC GGCTGCAATG CAGCCAGCAT CACCTGTCAG 3301 CTAGCATGTG ACTTCCCCGA GATTCTTTTT CTTACCCACT GCTAACTCCA TACTCAATTT 3361 CTCATGCTCT CCCTGTCCCA GGCTCAAGGA AAAACATGGA CTGCTATTGC AGAATACCAG 3421 CGTGCATTGC AGGAGAACGT CGCTATGGAA CCTGCATCTA CCAGGGAAGA CTCTGGGCAT 3481 TCTGCTGCTG AGCTTGCAGA AAAAGAAAAA TGAGCTCAAA ATTTGCTTTG AGAGCTACAG 3541 GGAATTGCTA TTACTCCTGT ACCTTCTGCT CAATTTCCTT TCCTCATCTC AAATAAATGC 3601 CTTGTTACAA GATTTCTGTG TTTCCACCTC TTTAATGTGT GATATGTGTC TGTGTCAAGA 3661 CACTTGGGAT ACACGTACCA AAACGCAAAA TCAAATTTTT GAACAATATA (2) INFORMATION FOR SEQ ID NO:2478: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 421 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2478: 1 CCTACCTTGC TATAGAAGAC CTGGGACAGA GGACTGCTGT CTGCCCTCTC TGGTCACCCT 61 GCCTAGCTAG AGGATCTGTG ACCCCAGCCA TGAGGACCCT CGCCATCCTT GCTGCCATTC 121 TCCTGGTGGC CCTGCAGGCC CAGGCTGAGC CACTCCAGGC AAGAGCTGAT GAGGTTGCTG 181 CAGCCCCGGA GCAGATTGCA GCGGACATCC CAGAAGTGGT TGTTTCCCTT GCATGGGACG 241 AAAGCTTGGC TCCAAAGCAT CCAGGCTCAA GGAAAAACAT GGACTGCTAT TGCAGAATAC 301 CAGCGTGCAT TGCAGGAGAA CGTCGCTATG GAACCTGCAT CTACCAGGGA AGACTCTGGG 361 CATTCTGCTG CTGAGCTTGC AGAAAAAGAA AAATGAGCTC AAAATTTGCT TTGAGAGCTA 421 CAGGGAATTG CTATTACTCC TGTACCTTCT GCTCAATTTC CTTT (2) INFORMATION FOR SEQ ID NO:2479: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 3781 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2479: 1 CCTGAGACAG AGGCAGCAGT GATACCCACC TGAGAGATCC TGTGTTTGAA CAACTGCTTC 61 CCAAAACGGA AAGTATTTCA AGCCTAAACC TTTGGGTGAA AAGAACTCTT GAAGTCATGA 121 TTGCTTCACA GTTTCTCTCA GCTCTCACTT TGGTGCTTCT CATTAAAGAG AGTGGAGCCT 181 GGTCTTACAA CACCTCCACG GAAGCTATGA CTTATGATGA GGCCAGTGCT TATTGTCAGC 241 AAAGGTACAC ACACCTGGTT GCAATTCAAA ACAAAGAAGA GATTGAGTAC CTAAACTCCA 301 TATTGAGCTA TTCACCAAGT TATTACTGGA TTGGAATCAG AAAAGTCAAC AATGTGTGGG 361 TCTGGGTAGG AACCCAGAAA CCTCTGACAG AAGAAGCCAA GAACTGGGCT CCAGGTGAAC 421 CCAACAATAG GCAAAAAGAT GAGGACTGCG TGGAGATCTA CATCAAGAGA GAAAAAGATG 481 TGGGCATGTG GAATGATGAG AGGTGCAGCA AGAAGAAGCT TGCCCTATGC TACACAGCTG 541 CCTGTACCAA TACATCCTGC AGTGGCCACG GTGAATGTGT AGAGACCATC AATAATTACA 601 CTTGCAAGTG TGACCCTGGC TTCAGTGGAC TCAAGTGTGA GCAAATTGTG AACTGTACAG 661 CCCTGGAATC CCCTGAGCAT GGAAGCCTGG TTTGCAGTCA CCCACTGGGA AACTTCAGCT 721 ACAATTCTTC CTGCTCTATC AGCTGTGATA GGGGTTACCT GCCAAGCAGC ATGGAGACCA 781 TGCAGTGTAT GTCCTCTGGA GAATGGAGTG CTCCTATTCC AGCCTGCAAT GTGGTTGAGT 841 GTGATGCTGT GACAAATCCA GCCAATGGGT TCGTGGAATG TTTCCAAAAC CCTGGAAGCT 901 TCCCATGGAA CACAACCTGT ACATTTGACT GTGAAGAAGG ATTTGAACTA ATGGGAGCCC 961 AGAGCCTTCA GTGTACCTCA TCTGGGAATT GGGACAACGA GAAGCCAACG TGTAAAGCTG 1021 TGACATGCAG GGCCGTCCGC CAGCCTCAGA ATGGCTCTGT GAGGTGCAGC CATTCCCCTG 1081 CTGGAGAGTT CACCTTCAAA TCATCCTGCA ACTTCACCTG TGAGGAAGGC TTCATGTTGC 1141 AGGGACCAGC CCAGGTTGAA TGCACCACTC AAGGGCAGTG GACACAGCAA ATCCCAGTTT 1201 GTGAAGCTTT CCAGTGCACA GCCTTGTCCA ACCCCGAGCG AGGCTACATG AATTGTCTTC 1261 CTAGTGCTTC TGGCAGTTTC CGTTATGGGT CCAGCTGTGA GTTCTCCTGT GAGCAGGGTT 1321 TTGTGTTGAA GGGATCCAAA AGGCTCCAAT GTGGCCCCAC AGGGGAGTGG GACAACGAGA 1381 AGCCCACATG TGAAGCTGTG AGATGCGATG CTGTCCACCA GCCCCCGAAG GGTTTGGTGA 1441 GGTGTGCTCA TTCCCCTATT GGAGAATTCA CCTACAAGTC CTCTTGTGCC TTCAGCTGTG 1501 AGGAGGGATT TGAATTATAT GGATCAACTC AACTTGAGTG CACATCTCAG GGACAATGGA 1561 CAGAAGAGGT TCCTTCCTGC CAAGTGGTAA AATGTTCAAG CCTGGCAGTT CCGGGAAAGA 1621 TCAACATGAG CTGCAGTGGG GAGCCCGTGT TTGGCACTGT GTGCAAGTTC GCCTGTCCTG 1681 AAGGATGGAC GCTCAATGGC TCTGCAGCTC GGACATGTGG AGCCACAGGA CACTGGTCTG WO 00/09525 PCT/US99/17712 EPI-109 613 1741 GCCTGCTACC TACCTGTGAA GCTCCCACTG AGTCCAACAT TCCCTTGGTA GCTGGACTTT 1801 CTGCTGCTGG ACTCTCCCTC CTGACATTAG CACCATTTCT CCTCTGGCTT CGGAAATGCT 1861 TACGGAAAGC AAAGAAATTT GTTCCTGCCA GCAGCTGCCA AAGCCTTGAA TCAGACGGAA 1921 GCTACCAAAA GCCTTCTTAC ATCCTTTAAG TTCAAAAGAA TCAGAAACAG GTGCATCTGG 1981 GGAACTAGAG GGATACACTG AAGTTAACAG AGACAGATAA CTCTCCTCGG GTCTCTGGCC 2041 CTTCTTGCCT ACTATGCCAG ATGCCTTTAT GGCTGAAACC GCAACACCCA TCACCACTTC 2101 AATAGATCAA AGTCCAGCAG GCAAGGACGG CCTTCAACTG AAAAGACTCA GTGTTCCCTT 2161 TCCTACTCTC AGGATCAAGA AAGTGTTGGC TAATGAAGGG AAAGGATATT TTCTTCCAAG 2221 CAAAGGTGAA GAGACCAAGA CTCTGAAATC TCAGAATTCC TTTTCTAACT CTCCCTTGCT 2281 CGCTGTAAAA TCTTGGCACA GAAACACAAT ATTTTGTGGC TTTCTTTCTT TTGCCCTTCA 2341 CAGTGTTTCG ACAGCTGATT ACACAGTTGC TGTCATAAGA ATGAATAATA ATTATCCAGA 2401 GTTTAGAGGA AAAAAATGAC TAAAAATATT ATAACTTAAA AAAATGACAG ATGTTGAATG 2461 CCCACAGGCA AATGCATGGA GGGTTGTTAA TGGTGCAAAT CCTACTGAAT GCTCTGTGCG 2521 AGGGTTACTA TGCACAATTT AATCACTTTC ATCCCTATGG GATTCAGTGC TTCTTAAAGA 2581 GTTCTTAAGG ATTGTGATAT TTTTACTTGC ATTGAATATA TTATAATCTT CCATACTTCT 2641 TCATTCAATA CAAGTGTGGT AGGGACTTAA AAAACTTGTA AATGCTGTCA ACTATGATAT 2701 GGTAAAAGTT ACTTATTCTA GATTACCCCC TCATTGTTTA TTAACAAATT ATGTTACATC 2761 TGTTTTAAAT TTATTTCAAA AAGGGAAACT ATTGTCCCCT AGCAAGGCAT GATGTTAACC 2821 AGAATAAAGT TCTGAGTGTT TTTACTACAG TTGTTTTTTG AAAACATGGT AGAATTGGAG 2881 AGTAAAAACT GAATGGAAGG TTTGTATATT GTCAGATATT TTTTCAGAAA TATGTGGTTT 2941 CCACGATGAA AAACTTCCAT GAGGCCAAAC GTTTTGAACT AATAAAAGCA TAAATGCAAA 3001 CACACAAAGG TATAATTTTA TGAATGTCTT TGTTGGAAAA GAATACAGAA AGATGGATGT 3061 GCTTTGCATT CCTACAAAGA TGTTTGTCAG ATGTGATATG TAAACATAAT TCTTGTATAT 3121 TATGGAAGAT TTTAAATTCA CAATAGAAAC TCACCATGTA AAAGAGTCAT CTGGTAGATT 3181 TTTAACGAAT GAAGATGTCT AATAGTTATT CCCTATTTGT TTTCTTCTGT ATGTTAGGGT 3241 GCTCTGGAAG AGAGGAATGC CTGTGTGAGC AAGCATTTAT GTTTATTTAT AAGCAGATTT 3301 AACAATTCCA AAGGAATCTC CAGTTTTCAG TTGATCACTG GCAATGAAAA ATTCTCAGTC 3361 AGTAATTGCC AAAGCTGCTC TAGCCTTGAG GAGTGTGAGA ATCAAAACTC TCCTACACTT 3421 CCATTAACTT AGCATGTGTT GAAAAAAAAA GTTTCAGAGA AGTTCTGGCT GAACACTGGC 3481 AACGACAAAG CCAACAGTCA AAACAGAGAT GTGATAAGGA TCAGAACAGC AGAGGTTCTT 3541 TTAAAGGGGC AGAAAAACTC TGGGAAATAA GAGAGAACAA CTACTGTGAT CAGGCTATGT 3601 ATGGAATACA GTGTTATTTT CTTTGAAATT GTTTAAGTGT TGTAAATATT TATGTAAACT 3661 GCATTAGAAA TTAGCTGTGT GAAATACCAG TGTGGTTTGT GTTTGAGTTT TATTGAGAAT 3721 TTTAAATTAT AACTTAAAAT ATTTTATAAT TTTTAAAGTA TATATTTATT TAAGCTTATG 3781 TCAGACCTAT TTGACATAAC ACTATAAAGG TTGACAATAA ATGTGCTTAT GTTT (2) INFORMATION FOR SEQ ID NO:2480: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 141541 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2480: 1 GATCAAAATT TTTACCTATT ATGCATTTGA TATATAAATA AGTATATAAA TGCACACACA 61 GACACAGCAA TGATGGTGAA CAGTCTTCAT ACAATTATAT GGATGAATCT CATAAAATGC 121 TGAGTTAAAG AAATCAGACC AAAGAACATA TACTGAAAGA TTCTCTCTAT ATACAAAGTT 181 CAAAAATAGG TGGACCAATT CATGGTGGTG TTAGAAATCA GAAGAGAGGC TACCTTTGTG 241 GGGAGGGGAC AGTTTAATGC CCAGAAGCGG TAAATAAGGA ATCCTCTGGG GAGTGGTAAT 301 GATCTGGATG CTGGCTACAG GATGTGTTGG TTGTAAAAAT GCATTTTTTT ATATCTAGCT 361 TTTTCCATGT GTATATTATA CTTCAAAGAA GTTCAGTTAA TAATTTCTCA TGTCACTGTA 421 GAGTAGCTCA GTTAGCCCCA GCAAGCCTCT GGCTTAATCT TGTTTTACCT TAAGCCATCA 481 GTCATTTACA AGTAGGAAAA TTCACAGGGA AAGTTAGAGT ATAAAATCCA GAATGAAGGT 541 TTACTGGGTA AGAGTCTCTC CATTTTCCAA AGCCCGTTTA TTTCTTGATT CCAGTTCTTA 601 AGAAGTCTCA GCATTGTGTC TTTTTCATGT ATCTTACAAG AAGACAGCAT GTGCTTCTAA 661 CACCTGATAC ATTGTATCTA CCAGCACTTG GTAAACAGAA AAGAACCACA TTTTTCTTGT 721 AGGAGAAATT TGGTGCCTAT TTCCTACCAG GCACCAATAA GTGGGACCAA TAGGTGGGAT 781 TAAAGATACA GTAGAAAGTA TTTAAAACTT GCCAGGGGGC AATAGTCTGA AAATAAGTAA 841 ATTGGTGCTA TAGAATGGAA GTTACAGGCT TCTTTCTTTT TTCCCACAAG ATCTGCTCCT 901 TGAGCCCCTA GAGACTTTTC TGTCTGTTAC TGTTTCTTCA TTCCTCATCT GCAGAGCCAG 961 CCCTGAGAAG TGCAGACCAA AGCCAGGGAA GGCTCTGCAA AGATGTACAA ATGGAAGTCA 1021 CCTTAATAAC CTCTGACTGC TGCGCATAAT ACATTTCACT CAAAAGAGGG GTTAAACAAT 1081 GGAACAGAAT ACAGAGGCCA GAAATAATGC TGAACACTGA CAACCATCTG ATCTTTGACA 1141 AAATCCACAA AAACAAGCAA TGGAGAAAGG ACTCCCTATT CCATAATGGT GCTGGGATAA 1201 CTGTCTAGCT ATATACAGAA GATTGAACCT GGGCCCCTTC CTTACATCAT ATACAAAAAA 1261 TAACTCAAGA TGGAGTAAAG ACTTAAATCT AAAACCAAAC ACTATAAAAA CCCTGGAAGA 1321 TAGCCTGGGA AATACCATTC TGGACATAGG ACCTGGCAAA GACTTCATGA CAAGACACCA 1381 AAAGCAATAG CAACAAAAAC CAAATTGACT AATGAAACTA ATGAAACTCT TTAGTTGTAC 1441 AACAGATAGT TTATCTGTAC AACAAAATAA ACTATCAACA GAGTAAACAA CCTACAGAAT 1501 GGAAAAATTT TTTGCAAACT ATGCATCTGA CAAAGGTCTA ATATCCAGAA TCTATAAGGA 1561 ATTTAAACAA ATTTACAAGC AAAAAAATGA CCTCATTAAA AAGTGGGCAA AGGACATGAA 1621 CAGATGCTTT TCAAAATAAG ACATTCACAC ATCCAACAAC CATATGAAAA GATGTTTAAC WO 00/09525 PCT/US99/17712 EPI-109 614 1681 ATCACTAATC ATTAGAGGAA TACAAATCAA AAGCATAATA AGATACCATC TAATACCAGT 1741 AGGAATGACT ACTATTAAAA AGTCAGACAA TAACAGATGC TGGTGAAGGT TGTGGAGAAA 1801 AGGGAATGTT TATGCACTGC TAGTGGGAAT GTAAACTAGT TCAGCCATTG TGGAAGAGAG 1861 TGTGGTGATT CCTCAAAGAA TGTAAAACCG AACTGCCTTT CAATCCAGCA ATCCCATTAT 1921 TGGATATACA CCAAAAGGAA TAGAAATTGT TTTACCGTAA AGGCGCATGC ATGCATATGT 1981 TCATTACAGC ACTATTTACG ATAGCAAAGA CATGGAATCG TCTAAATGCC CATCAGTGGT 2041 AGACTAGCTA AAAAAAAAAA AATGTGGTAC ATATACATCA CAGAATAGTA TGCAGCCATA 2101 AAAATGAACA AGATCATCAT GTCCTTTGCA GCAACATGGA TGTAGTTGGA GGCCATTATC 2161 CTAAGCAAAT TAATGCAGGA ACAGAAAGCC AAATACCACA TGTTCTCATT TATAAGTGAC 2221 AGCTAAATAT TGAGTACACA TGGACACAAA GAAGGGAACA ATAGACATGG GACCTACTTG 2281 AGAATAGAGG GTGGGAGGAG GGTGAGGATC AAAAAGTACC CATAGGACAC TGTGCTTATT 2341 ACCTGGGTGA TGAAATAATT TGCACACCAA ACCCCTGTGA CACACAATTT ACCTATATAG 2401 AAAACCTGTG CATGTACCCC TGAACCTAAA AGTTAATGGT GGGGGGGTGG GGTTAAGCTA 2461 CTTTGTGGTA TAAATCTGAG CATTCATATT AAAATAAAAT ATTTACCTCA TTAGAGTAAT 2521 TAACATTTAT TAAGCAAAGA GCCAAGTACC TTACACACAT GATGTTTAAT CTCACAATGA 2581 TCTTTAATCT CATAACAACC GTCCATTGTA TGTACATATG TGGAAATTGA GCCTTGGAGA 2641 GATTAAATGC ATGGGGCATG CCATTTGACT AGAAACTGGA AGCATCAGGA TTTAAACTCA 2701 GTTCTGAATG GTTTTGTAGG CTTTGTTTTT TCCACATTAT AGCATGGCCT GCCATGAAGA 2761 ACAGGTCCTT TCTGGTGTTT GTCTTGTTTG GTTTAAGTGA AGCAAATATT TATTTAAATA 2821 TTCAAGATAT GCTGTTAAAT TTTTACTCAA AAATTTGAGT ACAGTATGGA TCTTCTGAAG 2881 CCAAATAACT CTTATTCAAT GCTTAGTTGA GAAATTTTAT GGAGTAGTTC TCAATTTTTA 2941 TGTAGTTCCA CTGCAAAGGT AAGTCTTATG GAAAGATTCA CTGTAATTTT TTTTCCTCAT 3001 TTGGACATCA GCTTTTTCTT TTCCTCAGAC CCGCTGAAAG ATAATTTTTA AAATAAAAAC 3061 CTTGTTTTTA TATCAAGTGG GGACATTTTT TCCAAATGAA AACCGTGTAT TCATTTTATA 3121 TGATAAAATC AATGTTATTA TTTTTAAAAT TTTGATTTAA AAATCATTAA AAATAAATTT 3181 TCAGATATTA CCTGAAATTC TACCATCCAG AGATAATAGT GCTTAAAGAT TTGATATATA 3241 GACACACACA CATATATACA TATATATCAT CCTAAACTTC TTTGTATAAA TGTATATAAA 3301 GTTTTTAATA AAAACTAGGA GATTAATGCC CTTTGAATGA AAATAAATAC AATGTGTATG 3361 CTTTAACATC TTGCCTTTAC TTTATAACAT TTATCACAGC AGTCATGAGA TAATGATTTA 3421 CATGGTCATT GTTAGTAAGC TAATAGCTAA GTGCATGAAC TCTGGAGCTA GCCTCCCTGG 3481 ATTTTAATCC CAGATCTGTC ACTGACCAGC TGAGCAATAC TAGGTAAATT GCTCTTGTTC 3541 CTTAGTTTCT TCATCTGTAA AATAGAGATA AAAATAATAT CCACCTCATA GGATTGGTGT 3601 GAGCATTAAA TGAGCATACG TATGTAGGCC ACTTAACAAC AATGCCTTCA CATACTGAAC 3661 ACAAATATAC GAGCTGTTGT CTTATTGGGC TCATGTTTTT CCTACCACTA AGCCGCATGC 3721 ATGCAAGGAC CATGTTGGTT TTGTTCCACA TTGCATCCCC AACCTGGTAT ACAGTGTGCA 3781 TTCAATAGTT GTTGACTATT ATTACTAGTG GCATTTAACA AATATCTGTT AAATGAGTGA 3841 AGAAATACCC ATTTACTGCA AGTGTGTCTA ATATTGATGG CATAATGGGG GAAACTCAAA 3901 CTCTGGAGTC AAACAGGTTT TAAAACCTTA TTCCCTCATC CTCAGTTATT GACGTTTTTT 3961 TTTTGGCAGG TGTGTGTGTG GGACAACTTA TTGAACTTTT CTGAATTTCC AGCTTCGCAT 4021 ATATAAAATA GAGATAGTGA TTCATTCTTG CAATGTATGG ATTTGAGACA ATTGTGTAAG 4081 TTTATCAATA AATAGTAGCT ATTTTTGTAT AAGTATTACA TATAATATCC AGGCCACTGC 4141 TTTGCATAAC CCAAAAGGGG CACCATTCAT GCAGAATACA ACATAAATGG TGTCCCTGGA 4201 GCAGTGCAGT ATAGGAACCC TGAGGGGACC TACAGTATAC TTTATAGTTC ATAGATTACA 4261 AATTATCCCT TTATCAGAGT CTCTCAAGGT TGGATGTATT TGAGGTCCAT AAGAGCAATT 4321 TAGGATTAAC AGTAGCTGCA GAAACCATCT GCAGTGATAT TCTCATTTTA AATCCGCGGG 4381 AAAGAAGACA GCTATAAACT TGGGACCTGG GTTTAAGCAT TTTAAATGCC AAGTTCACCA 4441 TTTTCTAAAA CACAACAAAT ACCCAGTGAG AGAGGGAGAA GGGAAGTAAA TGCCTCTGAA 4501 TAAGCAAGTT AATGTCAGTA GTTGTACTGT ATGCATATTG ATGAACAATA GAGGAACCAA 4561 TGTCCAATCA GATGAGCAGG ATATTTGGCA ATAACAAGTT GCCTTTGAGG AAAAATGATT 4621 TTCTTGGCAA GTTCTTTATC AGCATTACAA AGCTAAAAGC TACGCTTATC ATCACTTATA 4681 CTAGCATACC CTGTTGTGCA AATGCTGTCT GTGTTTGCAT CTGCTATTGT TGATGCCTGG 4741 TGCATGAATC AGGACTCCAG CCCACAAGTT TTCCCAGAAC TTTCTTATGG CCATCATCTT 4801 TAAGTGTCTG GTGAACAGTC ATAGTTTGGT ACACAAAAGG GTCAACCTGG GGGATGGCTA 4861 GGGTTTGACT CAGTCGTTAC ATTTCAATAG AGCAGGAAGG GGAAATGGTG GCCTGTAACC 4921 TCAGGGAATT TTGCCAGTTG GTCCACCCCA CTCTCTCTCT CCTGCTCTGA GGAAGTGGCA 4981 CAGCCTAGAA CAGCACCACA GGTGAGAGAA ATGCAAACCC TAACCAGAGA AGCAGACTCT 5041 TTGCCAGTAG TAATAGTTCA GGACCACCAC CAGCTTTTAT TAAAATTTTT AATAACACTC 5101 AAGTATTGGC AGAAAGAAAT AATCTTGGGT TAACTATAAC TAGAATATTG ACTCTTCCTC 5161 TGTGGAAGAA TCAGCCAATC ACATTTGTTT ACATCAGTTC CCCTGAAGAA GAAAAATACA 5221 CTGATGTTGC AGCAAGACAA ATTTAAGCTA GATGTAAATA ACTTCCTTTA GCCTGTAATG 5281 CTAGGCTAAT TACATATTGG AACTATTTTT TCAGGGAAGA ATTGTGTAGG GTTTCAGGGA 5341 AGAATTCTGA AGAAAATATA GAGCTGAAAT GATCTTGCAG CTCACTGAAA CTGCAGGGTT 5401 TAGATCCACA CTGATACTCG TTCTATTATC ACTGTAATGA AGGCTGATGG AATAAGTAAA 5461 AATGTTTTGT ATTAGTATGT TTTTACACTT ATTTGCAAGG CATAAATAGG TTAGGTTTTG 5521 ATCTTAATTT AATTCTAACA TGTATTGTGC ACAAGCTGTG AGCAGTTTTC AGGAGTTAGG 5581 TATCTGGCCA TGACTGATTT TTCAGGAGTT AATCATCTGG TAGAAGGGTC ATACACAATA 5641 GGAAGATGTG TGTGACAGGT TGTGATCATT ACTATAATCA CACAGAGAGC TGTAGAATTT 5701 TAGGCTGGCA GGGTGGCTCA CGCCTGTAAT CCCAGCACTT TGGGAGGCCA AGGCAGGCGG 5761 ATCAAGAGGT CAGGAGATGG AGACCATCCT GGCTAACACG CTGAAACCCC GTCTGTACTA 5821 AAAATACAAA AAAAAAAAAA AGCCAGGCGT GGTGGTGGGC GCCTGTAGTC CCAGCTACTT 5881 GGGAGGCTGA GGCAGGAGAA TGGCGTGAAC CCGGGAGGTG GACCTTGCAG TGAGCCGAGA 5941 TCGCATCACT GCAATCCAAC CTGGGCGACA GAGGGAGACT CAGTCTCAAA AAAAAAAAAA 6001 AAAAAAAGTC ATGTTAGATC CAGAGGGGTA GCAACTGGGG CTGGCTGTC AGTCAACTCA 6061 GTCAACTCAG TCAACTCTGC TCCCCCACAG GAGATGCCAG TGATGCATTT TCATGGCCA 6121 CATTGTCAGT CAGCATCATT GAATTACTCC TGATTATAGA GACACAGCTG CAAACGATTC WO 00/09525 PCT/US99/17712 EPI-109 615 6181 CCCATTAAAT ATGATGTTTC TTGCAATGTT TGGAAGGTAC TCCTTTTTAG TAAGGGAAAT 6241 CCCCTCTTCT GGCTTGCTGA AAGTTTTTTC TTTCCATTTT AAAAATCGTG AATTCCTTTT 6301 TGCAATATTG AGGTGGTTAT ATGGTTTCTC TTCTCTAATC TGTTAATATG GTGATTTAAT 6361 GGTTAGAAAT TTTCTAATGT AAATTCCACT CATATTGCAG AAATAAACCT AAACTGAGCA 6421 TGAGGCTATA TTTTTTATTT GCTTCTATAT TTGGTTGCTA TACAGTATTA TGTTTAAGAT 6481 TTGTTCACAT ATATTTGTGA ATGGGATTGG ACTATTTTTC CTTCTTGCCG ATTTTTATCT 6541 GGTTTTTAAA TTAAGGATAT TTTAGACTTA TGAAATATTT GGCAAACAAT CCTTGGCAAG 6601 TAATTTTTTG GGGAATTTGT TTTGGCTATT TTGAGTATTA CCCAATATAT TTTAATTAAG 6661 TTATTCTTAA TGTTTTCTTA ATTAAAAAAA TTACCTACTC TAGAGATATT CTTTATGTAC 6721 TCCAGATTTT GTCTATTTAT ACCACTTTTC TTTTTTCCTC GATGAGTGTC ATAGATGTTC 6781 ATCTATTTTT TTATCTTCTT TGATCTTCTC TTATTCCTTG TTTCTATTAA CTTCTGAAGT 6841 TTATTATTTT CTTTTTTCCA CTTCCTTATG GTTTATTCTT TCAATTTTTC TCTAACTTCT 6901 TAAGTTGGGT GTTTAATTTT TAGCTTGCTT TGCTTTTTTA GGATAAGCAT TAAAACTACA 6961 AATTTTCCTT GTTATTCTTT TGCTGCACCC CAAATTGTTG ATATTTCTAT TGTCTAATTT 7021 CTATTCAATT AGAATACTTT AAAGTTTCTT TTTGGTTTTT AAAAACTAAC TTTTTAAATT 7081 GACAAATAAA AATTGTGTAT ATTTATTGTG CACAGCATAT GGCTTTGAAA TATATGTACA 7141 TTGTGGAATT GCTAAATTTA GCTTATTAAT GTATGCATTA TCTCACATAC TTATCATTTT 7201 TTGTGGTGAG AGCTATGTGA CTTTTGAACT TATGAGTTAT TTAAATATTT TTAAATTATT 7261 AAGCATATTG GGATTTTAAG TAATTTACCT TTTTATTATT AACTTATAAC AAGTAGAACA 7321 GTTACCTGT ATGATTCTAC ATCATTGAAA TTTATTGACA TTTCCTTCAT AGTCTATTAT 7381 ATGGTCTACT TTTGTTCATG TTACATCTGT AGTAGAACTC CTAATAGTT GAGTAAAGTA 7441 CACATATGTC TATGAAATCA AGTGTAATCC AGAGAAAAAG AGAAATTTAC TGAATATATT 7501 GTTCTAGGTG CTATTATATG TTGTCATGTT TAATCCTCAC CACAATTTA TGAGGCAGCC 7561 ATAATTAATT CCACTTTACA CATGAGGAGC CTGAGGGTTA AAAAAAAAGC TAGCTCTACT 7621 ATTTGTAAAG AATGAAGCAA AGATACAAAT GAAGGCCCAC ATATCCTATA ACTAGATATT 7681 TAAGCATTTT AATTCAAGCT TTAAAACTGC TAAATAAAAT ATCTCCAAT TTCTATATTG 7741 ACAGACATAC CTTCCTAATG AGCTGGGGTT CGAATTTAGA AATCTTTGAT GCTTCAGAGT 7801 CCACACTGAA ATGTGGAGGC ACATAGTGAG TTGGTCCCCA GCCTTCAGTC CACCCACCTT 7861 CTCTTTACTA AATCACCTTT CACATACATG TATGAACACC CCAGCCTCCA AGTCCAAACC 7921 CTAAACAAAA TGGGACACCC TTGTGCATAC ACAGAGACAC AGCCCATCCT CAGGAAAACC 7981 TGGAAAAGTC CATACAAGTT CTGGAAGCAA GCTTGGGACG GTTTCAGTAG TGTGGTCTAT 8041 AAGGGAGGCC TCAGAAGACA GGTTTTCTTA ATTCTGTGAA CTTCTCCCAC AGTAGAAAGG 8101 GTGCTGGAGG AGGGTCAGAG TGAGGACTTC TAAAGCATGG GTCCTGAGTA GGGGCCACTC 8161 TTGCCCAAGT CTAAGAAGGG TACTAGAATA GCACACTACT ACTAGATACT AGAACCCAGA 8221 TACAAGCACA GGTCTTCTGA AATTAATAAT AATAATAACT ATTACCATTA TTATACCAGT 8281 AGCTGTCATT TATTTAGTGC TTATTATTTG CCAGTCACTG TTCTAAATTC TTTACATGTA 8341 TTATACAACT GCCATATAAC TGCCATATGA GGGATGTACC CTCATTGTCA CCATTTTACc 8401 GATGAGAAAA CTGGCATAAA ACGTTTAAGT AACTTGTCCA AGTTACAGAG CTTAGTGAAG 8461 CCACAATGTT GCTCAATTTG CTCTCAAACT TCAAAGGGAT GGGAAGGACA CCTAAGTCAT 8521 AGAGTCTTTA AGAATCAGAG CTAGAAGGAA TCTTAGATGT TATCTAGTCA GCCTCCTCCC 8581 ATTACAGTCC AAGAGAAGAT GGCCCTGAGT TACTTGTAGC TATTTTTGCA TGTGAATTGC 8641 AAGTGAATAT ACATTCTACT GAAGATAAAA GATATTTAAA GATATCGCTG GATATAGGAA 8701 CAGTGGTTTT AAATCTCTAG GCTTTAACTT TTCTCAGAAC AAGAAATCCT TTTTGGTTTT 8761 AATCTATATG CACATCTGTA TTTTTCTCAA TTATCGGGTA GTAAAATATA ACTTTTCTTC 8821 TGTAATATTT TTTAACTTTA ATGAGTGTTC CTCATAATAG AAAAGTTTGG AAACCATTGC 8881 TATGGGTATA TACTTTCTAA AGGGATAGTA ATTTCTCTAG AATATTCATT TAATGCTCCA 8941 GAAGTAATTA GCACAATTGT GCAAGTCTGT GCATCATCAA CTATACATTC TGCCTGTTTA 9001 CTCCAAATCC ACATGAAACT GATTATACAG TCAAAGGCGA GCCCAGTGGA GAGGCATTTT 9061 TGGAGACTTC CTGGTACATT GAGACAGGGT CGGCCAGTCT GCGTTAGGGT CTTGGTCAAA 9121 ACTGCATTTC TGAAACTAAA CTCAGATTGC TTTCTTTTAA GGGGTCAGAA CTGATTCAAA 9181 TCTACATTTT TAAAAGCCTT AGATGTGGGG CTTTTCCTAT TCCCAGTCTC CGCTATTGGT 9241 CTTTGTGAAT CCACAGGCAA TTTGGCCACA TCCTTGACTC TCTCTTATAT TAAGAATTAA 9301 ACAGCTAAGT TCATGCAGAG GAAATATAAC AAAGGAGGGA CTTTCCTACA AGATCTTTGA 9361 AAAATGGAAC ATTTGCATAA GTCATATTTA GCCAGAACTG TTGTTTTATA TTTTCCTTTC 9421 TGAATACTTT GTTACACCTC CTCCCAGCCA ACCCCCCCCC TCCCTGACCC CAACTAGTCA 9481 GAGACCAAAG CCTTCACAAT GGTTTACACT TGAACCTTCC TGGCCCCACC CTCATCATCA 9541 CGCCTGAATA ATTACATTCA CTGACTGGTC TCCCCTGCTT CCGTTTATCT CCACTCCTAA 9601 ACCCTCTGAC ACCTTAATCT TCCCAGAATA CCATTGTGAT CCTGTTCCAC TCTTGCTCAA 9661 GTTTTCCCAG AAACTAGAGT ACAAACTTTA TAAGCTTTAG AGTTGAAAGC CACTCTATCT 9721 CTTTTTCATC CCCAGGTCTC TGCCAAGGCA GTATAACCTG TCCAACATCT CTAACTTCAA 9781 TACCTTTGTC TTAGATACTA GACTCTCCTC CTGGTTTCTA ATTAAACCTG ATCTAGGATC 9841 TAATTTTGCC TCTGAATTCT GTTGCCCTTT GCCAAGTGAT CTCTTCCTCC TCTGAGCCGC 9901 AGCATCTCTG AGCTTGCACA CTTAGCATAG CCATAGCACA CACAGCCTTA GCTTGCAGTT 9961 CAGGGTGTTT ACCTTCCCTC CCCTTCCAGA TGCTGGATCC CCAGGGATAG GAACTCTGCC 10021 CTTATGTGTC CATAGCCCCT GGTAGTATGT CTTGCAGTCG TACATTTTCA GCAAATGTTT 10081 AATTGGTTAA TTGAAGACAA CTGTCCCATG CCTTAAGCCT CTCTTTTTGC TAAACATGCC 10141 TGTGTCCTTT GTCATTGAAC AACTATTTTG ATCTATTTTC TTCCTGACAT AGGGGTCAGT 10201 TCCGAGGATG CTGAAATCAA GAGACATAGC TTATTCTCTC AAAATTGCTT TCAAGAGTGA 10261 TTTTGTTGTG AATTGAGAAC TGGCTGCCTA CTTTTGGACT ACCCACTTCA GCAAGAGTGT 10321 TTGAAACCAA ATCTATTCTA AGTAATTTTT TATTCCCTTT TCTCTATGGC ATTAGACACA 10381 CAGCTCTTTT AAACTACCTT TCGTTATCTA TTAAACAGAC ATTCAGTAAC TCTATAGACA 10441 CTGTCTAGCT ATATGAACTT AGACAAACTA ATATCTCTGA GCTTCAGTTT CTTAAAATTT 10501 AAAATGAGGA CAATACCATC TATGGCCGGG GATTAAATGC TATGAGGAAT GTAAACCAGA 10561 TGTCAGGTAC CATCTCTCTA AAATCCAGAT AAAATGAATT AAAAATACTG GCCGCAAACC 10621 CTCTCTAAGA GTTCTCAAAA TTCTCAGAGA GCTTAATTTT CATGCTCACC ATAGCACCGA WO 00/09525 PCT/US99/17712 EPI-109 616 10681 TTTTCTTCTA AATATTTTGT TTCTACCAAA ATATTTTGTC CCAATTTTGC CTTTTATGGC 10741 TATTTCTTCA TATCCACTTT CCCAAACTAA AGAAGCAGCC CCTTCACCTT AAACTCCTCC 10801 TTCAAAGCAA CCTAAATACA GGTCTGGGTT TGTATTCCTA GTGGGATGTT ACAGAGGTTA 10861 GTGTGATGCA GAGGAGGAGT CATGCTGTTT AAATCCATAC TAGTCCCCAG AGGCCAGGCT 10921 GCTTCTGCCA CCCCTACCCC TCCCGCCACA GAGCTCTTCA GCTTCTCACA TTTCTAGTTC 10981 TTCTCTCTCT ACTTTCATTA CCTTCTCTCT TTTTTTTTTT CTTCTCATGT GCTCACGGGA 11041 GCAGAGAAAA TTAACTCCTC TAAGTTTTCT TAACACAGAG TGCCTTAATT ACATATTACT 11101 ATTGTTTGAG TTCCTGCCAA CACTACGTCT GTAGGGTCAC ACCTGCTATA TTAGAGGCTT 11161 ATCAAAAAAA GATAGCTTTC TCCTAAAAAG GGATTTGGAT GCCTACTAAG ATAACTGGAT 11221 GCCAAGATAA GTTTAACCTA ACAAACTTTA TTATTATTAT TATTATTATT ATTAGAGATA 11281 GGTACTTATT CTGTCACCCA GACTGCAGTG CAGGGATGCA ATAATAGCTC ACTGCAGCCT 11341 CAAAGTCCTG AGTTCATGCA ATCCTTCTGC TTCAGCTCCC TGAGTAGCTA GGACTACAGG 11401 CATATGCTAC TCTGCCCAGC TACTTTTAAA AAAATAATTA GGGATGGGGT CTTGTTGTAT 11461 TGCCCAGGCT CGTCTCAAAC TTCTGGTTTC AAGCAATCCT CCTGCCTTTT ACCTCCCTAA 11521 TTGTTGGAGT TACAGGCATG AGCCACAGCA CTCAACCAAG ATTTAAAAAC TTTTAAAAGA 11581 AATCACATTA CTTACTGTTA TCATCATTAT GGTTACTACC AGTGTTAAAA CAATTGGTAT 11641 TGAAAACACC ACTACCAGAT CAAGCTTCAA ACCAAGATGT CAAGTAAATA TTATTGTCAG 11701 ACCTCTGAGC CCAAGCCTGC AGGTATACAC CCAGATGGCC TGAAGCAAGT GAAGAATCAC 11761 AAAAGAACTG AAAATGGCCG GTTCCTGCCT TAACTGATGA CATTCCACCA TTGTGATTTG 11821 TTCCTGCCCC ACCTTGACTG AGGGATTAAC CTTGTGAAAT TCCTTCCCCT GGCTCAGAAG 11881 CTCCCCGACT GAGTACCTTG TGACCCCCAC CCCTGCCCAC AAGTGAAAAA CCCCCTTTGA 11941 CTGTAATTTT CCACTACCCA CCCAAATCCT ATAAAACAGC CTCACCCCTA TCTCCCTTCG 12001 CTGACTCTCT TTTCAGACTC AACCTGCCTG CACCTAGGTG ATTCAAAAGC TTTATTGCTC 12061 ACACAAAGCC TGTTTGGTGG TCTCTTCACA CAGACCATGT GACATTTGGT GCCGTAACTC 12121 AGATCGGGGA ACCTCCCTTG GGAGATCAGT CCCCTGTCAT CCTGCTCTTT GCTCCATGAG 12181 AAAGATCCAC CTATGACCTC TGGTCCTCAG ACCAACCAGC CCAAGGAACA TCTCACCAAT 12241 TTTAAATTGG GTAAGTGGCC TCTTTTTACT CTCTTCTCCA GCCTCTCTCA CTATCCCTCA 12301 ACATCTTTCT CCTTTCAATC TTGGCACCAC GCTTCAATCT CTCCCTTCCC TTAATTTCAG 12361 TTCCTTTCTT TTTCTGGTAG AGACAGAGGA AACGTGTTCT ATCTGTGAAC CCAAAACTCC 12421 AGCACTGGTC ATGGACTTGG AAAGACAGTC TTCCCTTGAT GTTTAATCAC TGCAGGGATG 12481 CCTGCCTGAT TATTCACCCA CATTTCAGAG CTGTCTGATC ACTGCAGGGA CGCCTGCCTG 12541 GATCCTTCAC CTTAGTGGCA AGTACCACTT TGCCTGGGTG GCAAGCACCA CCTCTCCTGG 12601 GGGGCAAGCA CCACCTCTCC TGGGGGGCAA GTACCCCCCA ACCCCTTCTC TCCATGTCTC 12661 CACCCTCTCT TCTCTGGGCT TGCCTCCTTC ACTATGGGCC ACCTTCCACC CTCCATTCCT 12721 CCCTTTTCTC CCTTAGCCTG TGTTCTCAAG AACTTAAAAC CTCTTCAACT CACGTCTGAC 12781 CTAAAACCTA AATGCCTTAC TTTCTTCTGC AATACCGCTT GACCCCAATA CAAACTCAAC 12841 AATGGTTCCA AATAGCCTGA AAACGGCACT TTCAATTTCT CCATCCCACA AGATCTAAAT 12901 AATTCTTGTC GTAAAATGGA CAAATGGTCT GAGGTGCCTG ACATCTGGGC ATTCTTTTAC 12961 ACGTCGGTCC CTCCCTAGTC TCTGTTCCCA ATGCAACTCA TCCCAAATCC TCCTTCTTTC 13021 CCTCCTGCCT GTCCCCTCAG TCCCAACCCC AAGTGTCGCT GAGTCTTTCC AATCTTCCTT 13081 TTCTACTGAC CCATCTGACC TCTCCCCTCT TCCCCAGACT GCTCCTCCTC AGGTCGCTCC 13141 CCGCCAGGCT GAATCAGGCT CCAATTCTTC CTCAGCGTCC GCTCCTCCAC CCTATAATCC 13201 TTCTATCACC TCCCCTCCTC ACACCTGGTC CAGCTTACAG TTTCATTCTG TGACTAGCCC 13261 TCCCCCACCT GCCCAACAAT TTCCTCTTAA AGAGGTGGCT GGAGCTAAAG GCATAGTCAA 13321 GGTTAATGCT CCTTTTTCTT TATCCAACCT CTCCCATCTC AGTTAGTATT TAGGCTTTTT 13381 TTCATCAAAT ATGAATACCT AGCCCACTCC ATGGCTCATT TGGCAGCAAC TCCTAGACAT 13441 TTTACAGCCT TGGACCCAGA GGGGCCAGAA GGTCATCTTA TTCTCAATAT GCATTTTATT 13501 ACCCAATCCA CTCCCAACAT TAGAAAAAGC TCCAAAAGTT AGACTCCGGC CCTCAAACCC 13561 CACAACAGGA CTTAATTAAC CTTGCCTTCA AAGCGTACAA TAATAGAGTA GAGGCAGCCA 13621 AGTAGCAACA TATTTCTGAG TTGCAATTCC TTGCCTCCAC TGTGAGAGAA ACCCCAGCCA 13681 CATCTCCAGT ACACAAGAAC TTCAAAATGC CTAAGCCACA GTGGTCAAGC ATTCCTACAG 13741 GACCTCCTCC ATCAGGATCT TGCTTCAAGT GCCAGAAATC TGGCCACTGG GCCAAGGAAT 13801 GCCCTCAGCC TGGGATTCCT CCTAAGCCAT GTTCCATCTG TGTGGGACCC CACTGGAAAT 13861 CGGACTGTCC AACTTGCCCA GCACCCACTC CCAGAGCCCC TGGAACTCTG GCCCAAGGCT 13921 CTCTGACTGA CTCCTTCCCA GATCTTCTTG GCTTAGTGGC TGAAGACTGA TGCTGCCTGA 13981 TCGCCTCAGA AGCCTCCTGG ACCATCACAG ATGCTTTTGG TAACTCTTAC AGTGGAGGGT 14041 AAGTCCGTCC CCTTCTTAAT CAATGCAGAG GCTACCCACT CCACATTACC TTCTCTTCAA 14101 GGTCCTGTTT CCCTTGTCTT CATAAATGTT GTGGGTATTG ATGGCCAGGC TTCTAAACCC 14161 CTTAAAACTC CCCAACTCTG GTGCCGATTT AAACAACATT CTTTTATACA CTTCTTTTTA 14221 GTTATCCCCA CCTGCCCAGT TCCCTTATTA GGCTGAGACA TTTTAACCAA ATTATTTGCT 14281 TCCCTGACTA TTCCTGGACT ACAGCCACAT CTCATTGCTG CCCTTCTTCC CAACCCAAAA 14341 GTGGCAACTC CTTTGCCACT TCCTCTCATA TCCCCCTACC TTAACCCACA GGTATGGGAC 14401 ACCTCTACTC CCTCCCTGGC AACAAATCAC ACCCTCATTA CTATCCCATT AAAACCTAAT 14461 CACCCTTACC TGGGTCAACG CCAGTATCCC ATCCCACAAC AGGCTTTAAA GGGATTAAAG 14521 CCTGTTATCA CTTGCCTGTT ACAACATGTC CTTTTAAAGC CTGTAAACTC TCCTTACAAT 14581 TCCCCCATTT TACCTGTCCA AAAACTGGAC ATGCCTTACA GGTTAGTTCA GGATCTGTGC 14641 CTTATCAACC AAATTGTCTT GCCTATCCAC GCCATGGTGC CAAACCCATA TACTCTCCTA 14701 TCCTCAATAC CTCCCTCCAA AACCCCTCCA TAACCCTTAT TCTGTTCTGG ATCTCAAAAC 14761 ATGCTTTCTT TACTATTCAT TTGCACCCTT CATCCCAGCC TCTCTTCACT TTCACTTGGA 14821 CTGACCCTGA CACCCATCAG CCTCAGCAAC TTACCTGGGC TGTACTGCCG CAAGGCTTCA 14881 TGGACAGCCC CCATTACCTC AGTCAACCCA AATTTCTTCT TCATCCATTA CCTATCCAGG 14941 CATAGTTCTT CATGAAAACA CACGTGCTCT CCCTGCTGAT CATGTCCAGC TAATCTCCCC 15001 AACCCCAGGA CTGGCAAATT GACTTTACTC ACATGCCCCA AATCAGGACA CTAAAGTACC 15061 TCTTGGTCTG GGTAGACACT TTCACTGGAT AGGTAGATGC CTTTCCCACA GGGCCTAAGA 15121 AGGCCACCGT GGTCATTTCT TCCCTTCTCT CAGACATAAT TCCTTGGTTT GGCCTTCCCA WO 00/09525 PCT/US99/17712 EPI-109 617 15181 CCTCTATACA GTCTGATAAT GGACAAGCCT TTACTAGTCA AAGCACGCAA GCAGTTTCTC 15241 AGGCTCTTGG TATTCAGTGA AACCTTCATA CCCCTTACCG TCCTCAATCC TTAGGAAAGG 15301 TAGAACTGAT TAATGGTCTT TTAAAAACAC ACCTCACCAA GCTCAGCCTC CAACTTAAAA 15361 AGGACTGGAC AGTACTTTTA CCACTTGCCA TTCTCAGAAT TCGGGCCTGT CCTCGAAATG 15421 CTACAAGGTA CAGCCCATTT AAGATTCTGT ATGGACGCTC CTTTTTATTA GGCCCCAGTC 15481 TCATTCCAGA CACCAGCCCA ACTTGAACTG TGCCCCAAAA ACTTGTCATC CCTACAATCT 15541 TCTGTCTAGT CATACTCCTA TTCACCATTC TCAACTACTT GTAAATGCCC TGCCCTTTTT 15601 TACAGTGCTG ATTTATACTT TTCCTCCAAA CCATCATAAC TGATATCTCC TGGTTTTACC 15661 TCAAACCGCC ACCCTTAAGT CTCTCTTAAA GTGGATAGAA GATCTTCAGT GACAAGGTAC 15721 ACTCCAATAC TTTCACCCTA ATAAAGCCCT ATTCTTTACT TTTATATTCA CTCTTATTCT 15781 TGTTCCCATT CTTATGCCAC TCTCTACCTC TCCCCAGCTA TCTCCACCAC ACTATCAATC 15841 TCACTCACTC TCTCCTAGCC ATTTCTAATC CTTCTTTAAC AAACAATTGC TGGCTTTACA 15901 ATTTCTCTTT CCTCCAAAAT CACCGAGTCC TCAATTTACT CACTGCTAAA AAAGGGGACT 15961 CTGCATATTT TTAAATGAAG AGTGTTGTTT TTACCTAAAT CAATCTGGCC TGGTATATGA 16021 CAACATAAAA AAAACTCAAG GATAGAGCCA AAAACCTTGC CAACCAAGCA AGTAATTATG 16081 CTGAACCCCC TTGGGCACTC TAATTAGATG TCCTGGGTTC TCCCGATTCT TAATCCTTTA 16141 ATACCTGTTT TTCTCCTTCT CTTATGCAGA CCTTGTGTCT TCCATTTAGT TTCTCAATTC 16201 ATACAAAACC GTATCCAGGC CATCACCAAT CATTCTATAC GACAAATGTT TTAAGGGAGG 16261 AGACCACCCC TCATATTGTC TTATGCCCAA TTTCTGCCTC CAAAGAAAGA AGTAAAAATG 16321 AAAAGGCAGA AATGAAATCC ACAGGCAGAC AGCCTGATGC CACACCCTGG GCCTGGTGGT 16381 TAAGATCAAC CCCTGACCTA ATCAGTTATG TTATCTATAG ATTACAGACA TTGTATGGAA 16441 AAGCACTGTG AAAATCCCTG TCTTGTTCTG TTCCTCTAAT TACCAGTACA CGCAGCCCCT 16501 AGTCATGTAC CCCCTGCTTG CTCCCCCTGC TTGCTCAATC AGTCATGACC CTCTCACGCA 16561 GACCCCCTTA GAGTTGTAAG CCCTTAAGAG GAAAAGGAAT TGTTCACTCG GAGAGCTCGG 16621 TTTTTGAGAC ATGAGTCTTG CCAATGCTCC CAGCTGAATA AAGCCCTTCC TTCTTTAACT 16681 CAGTGTCTGA GGGGTTTTGT CTGTGTCTTG TCCTGCTACA GTTTCATCTA ACAACCCCAT 16741 AATATCACCC CTTACCACAA AATCTTCCTT CAGCTTAATC TCTCCCACTC TAGGTTCTCA 16801 CGCCACCCCT AATCCTGCTC GAAGCAGCCC TGAGAAACAT CGCCCGTTAT CTCTCCACAC 16861 CACCCCCAAA AATTTTCACT GCCCCAACAC TTTACCACTA TTTCGTTTTA TTTTTCTTAT 16921 TAATATAAGA AGATAGAAAT GTCAGGCCTC TGAGCCCAAG CCTGCACGTA TACATCCACA 16981 TGGCCTGAAG CAAGTGAAGA ATCACAAAAG AAGTGAAAAT GGCTGGTTCC TGCCTTAACT 17041 GATGATATTC CACCATTGTG ATTTGTTCCT GCGCCACCTT GACTGAGGGA TTAACCTTGT 17101 GAAATTCCTT CCCCTGGCTC AGAAGCTCCC CCACTGAGCA CCTTGTGACC CCCACCCCTA 17161 CCCACAAGTG AAAAACCCCC TTTGACTGTA ATTTTCCACT ACCCACCCAA ATCCTATAAA 17221 ACAGCCCCAC CCCATCTCCC TTTGCTGACT CTATTTTTGG ACTCAGCCCA CCTGCACCCA 17281 GGTGATTCAA AAGCTTCATT GCTCACACAA AGCCTGTTTG GTGGTCTCTT CACACCGACA 17341 CGCGTGATAA TTATTATATT ACTTTTAACT AAAACCCTTT CAGAGTCTCG CAGGGAAGGC 17401 TGTATATATC TCATAAAATG TTGGGGCCCA CTGGATCAGA CAAGGCCACA AAGGCCAAAG 17461 GGAAGTAAAG ATCTCATTAT TTCTCCTAAT AATTTCCCTG TCCTTTGTCA TAAATGGTGG 17521 GTAGGCTGTT ATGGTGATGG CAGATTTTCT TTCCATAAAA TGTCCATAAT AGGACATTTG 17581 AACAGAAGGG AAAAATCAAA TTGCTGAAGT TGAAAGAGGG CAATGCAAAG AACTTTGGAG 17641 AAAGAACTGT ACAGAGAAGT CAACTGGCAG ATGGGAGGAA GTTTAAGGGG AAAAATATAG 17701 ATGTCTAAAG AATACATTTA TTCATTTTCC ACAGTGCAAT TTGGACAAGA AGCCTCTTTC 17761 TTGCTTCTTT CTATTCTCAT TAAATCATTA GAGCTCAAGC AATCCTTCTG CCTCAGCTTC 17821 CCGACTAGCT AGGACTACAG GTATGTGCTA CTATGCCCAG CTAATTTTTT AAAAATTAGA 17881 TTTTAATTTG GTGAACTATT TCTGTAGGAA ACTACAATAA TACAGCCCAG GCACATTGAT 17941 CTTGGGTGAA CAAATCAGAA GGAATGAATA ATTCTGTGTT CCTGGGACTC TGACAATTTC 18001 ATGAACTTGG TACTCTGAGT AAAGCATAGG AGGAGTTATT TCATAAAATG TGGAGCACAA 18061 TCATGTGACA AAGATAATGG GATCCCCATT TCATAAATAA ATCTGAAGTT CAGAGAGAGT 18121 AACAACTGGC CAGGGTCACA TCACGGAGAC AGAGGCAGGG TTCCCACTGA TGCCTCTGAC 18181 TCCCTGTCCC AGGCCCTTCC TCCTCCCGCA AGCAGAAGTG CAGGGGGCAG AGCTGACCCT 18241 GTGCAGTGAA AATCTGAGGG CTGAGTTCCT ATTGGAACAC AAGTGAAAGA CTTCCTGGCT 18301 TCTAATCTCA GGATAAGGAC TCAGAGCTCC ATCTGTTCCA GCCTTAGGAT AAGAACCAGA 18361 ATCTTACACC ATGAAAGCAT GAAAGGTAAG ATTTGAGTGA GGAAAAAAAA AAAAAAAGTC 18421 TGTGTTTCAG ATTCAGTTCA CAAAGCAGTT TCATACTTAA GGTACCATCA CAATAACCCT 18481 GTGGGGTAAG CAAGGCAAAT TTCATTCTTG TTTTATGGGC ATAGGAAGTA AGTCTCAGGG 18541 AGGTTAAGAC CAAGGTTTCT GGAGAATTTT ATATTATGAA TCTTGATTTA TGGGATTACT 18601 ATTATGTAAT TCCTAAGATC ATATAGGAAT CCTAGAGCTT GAATATAGAA CTTTATTTTT 18661 AAATCTATAT ACATCATAAT TACAAGGAGT AGTGTCCATT TGGGTTCCTT GGCCCTGATG 18721 TGTTAGTGGA ATAAACATTT TTGTCAGGGT TGCCATGTGT GTCTGTGCAC GTGTGCACTG 18781 TACACCTCCA GGGGATGTAC CCTAAACCAC ATGAATGTGA TTTGCACATC CAAGATTTAC 18841 AGTGTACTAT AGGGAGAATC TTTTGCAACA GCTTTTGCTA TAATACAGAA TCTGAGATGT 18901 CTTTGAGAAA GAAAAGTGTA ATCATTACCA AAAAATTATT CTCATAATGT GTGCAAATTT 18961 GTATGAAATC TATATTGGCC ATGGGACAAG GAGGTATTTC CAGCTAGCTT CTGAAAGGGC 19021 TCTATTCTCT CATAAGAATT CAGCTGTTGA CATTAGGTGA TATCTGCCCA GGTCATCAGA 19081 TGCCATAGAG AAAGAGGGTT TGCTGAAACT TATATCAGCA GTGCACTGTA TGCTCTTTCT 19141 GATTTATTTG AACATTCATT TATTGAGTGT CAAGTAATGC ACTAGATACT CCAGGGATCT 19201 GACACAAACT CTGCCCTGAA GGAGCATGTA ATCTCACTGG GGAGAAAACA AAACATATGA 19261 TAATTTCAAA ATAACAAACT AGGCAAACTA GTTAACACTT AAAAAGCAGG CTTTATTCAA 19321 ATGCAAAATT GCATGTTACA GGGTAACCTT TCAGTAAGAA GCCAGGAAGA GGAGCTCATC 19381 ATGGGTTGGA TTAGTAAAGG ACTAGTTATA AAAGAAGTGG TGGGGTTGAG GGAGGCCTGA 19441 GATGAAATTT AAAGAATATG TAGAATCTAG GTAAGTGGAT AAAAGGTCTG GGGGCAGGGG 19501 AAAGGAGAGC ATTTCATTGT GAATCAAGGA ATTTCTCCAC CTGTTTTAAC TCTTCCATAT 19561 GACATCAAAG AGATGTCACT TGCAGCTAGC ATTTCAGTGA TGTTTTCTTA CTAATAATAT WO 00/09525 PCT/US99/17712 EPI-109 618 19621 CGTGATAAAA GAAACATTGA CTATAAGAAA TAGGAATGGG TCTCATAAAA GGAAACAGCA 19681 AAACCCCCAA ACTAAAAAAC AGCGCAGGCT ATTTCTCTCT TCTCTCCTTT TGCTTGGCAC 19741 TCATGAGATG CTAGGTGTGG AAGTCAGCCA ACTGAAAAAG AGAGGTGGCT GAAGAAGGTG 19801 GGGAGGCTGA AGCCAGTTAA ATAGGATGGT CCAATTCACA GACGGCGAGG CTACAGTGCA 19861 AATAGGACTC TTTCAACTTG AGCAGGACCC CATTACTTCA CTGGAGTTAG AAAGAAAGGA 19921 GAGCGTAGAC TTTTTGAACT TTCTATAAGA GTGTACCTCC ACAGTATACA GAAGACGACG 19981 TGAAATTTGA TCTGCAAGAA AACTGAGTCC ATATTCACAT ATGTATCAAA TTTGCACTTC 20041 ATTTAGAAGT GTCTGTCATC AAGTACAGCA CTGAATTGAA ACTGAAAACA AGAGTCAAGA 20101 AAGAGCAAAG TCAGCCATCT TTATATTCCA CATGAATCCT TTCCCTTTAT GGTCTTATTT 20161 GTTTCTCCTC AGAAAAGACA AAAAGCTGAG CTGTATAAAC ACCTGTGGGC TGGGGGTTGA 20221 GGGATAAATG AGGGGCGAAA TGGAAGCTGA AGGAACTGTT GGTCAGGTAG AAATCTTCCC 20281 AGATGCACTG AAGGAAACAC ACTTCATGTT TGACGTAGGA GGTGCCACCA CACAAAACGT 20341 TTCATGGAAG GATTTAAAGG ATCTCATGAT TTTTAGTATT CCAAGAATTT TCTTTCACCA 20401 AGGGCGATTT AATATGGGTC ATTCATACTG AAAGAAAAAC AAAAGATAAT AAGAGTTTAA 20461 AAATTGCAAA ACTTGGAGTG TTAGTAGTAA AGGTAAATAT TCATTAGAGA TGAGAAGAGG 20521 AGCAAGGAAA TGCTTTCAGC TGGAAATCTC AGACAAGAGG CCAGGCTTTA GGAACCTCTG 20581 AAGATGAACA AATGTAAGCA AACCCTAGTA GCAGCACTTC TCAGATTTTC ATGTGCTTAC 20641 CACTCAGAGA TGGTGTTAAA ATGCAGACTC TGATTCAGTA GGTCTGAGTG GAGCCTGAGA 20701 TTCTGCACCC CTAACAAGCT CTTTAGTGAT GCTTATGCCA CTGGCGCACA GACCCCACTT 20761 GGAGAAATTT TTGTGGTGCA TACGGTCTTT GTCTCCAGAT CTAATGAGTC TGAAGGACAG 20821 TGTAGATTGA TTTTTTAAAT TTATGTTTAT TTTAATTTAA TTTAATTTAA TTTATTTATT 20881 TATTTATTTT TGAGATGGAG TCTCACTCTG TTGCCCAGTC CGGAGTGCAG TGGCACGGAG 20941 GCAGCTCATG CAACCACGGC CTCCTGGGTT CAAGCGATTC TTCCGCCTCA ACTTCCTGAG 21001 TAGCTGGGAA TACAGGCACG TGCCAGCACA CCCAGCTAAT TTTTGTATTT TTAGTAGAGA 21061 TGGGGTTTCA CCACATTGGC CAAGCTAATC TCAAACTCCT GACCTCATGA TCCACCTGCC 21121 ACGGCCTCCG AAAGTGCTGG GATTACAGGC GTGAGCCACC GAGCCCAGCT GTAGATTGAT 21181 TTTGAGCAGT GGAAAGTCAA GGAATTAGAA GGCATGCTTA AATGGAAAGT GAAATTGGAG 21241 AAAATTTAAA CTCATGAAAT AGTGGTGGTT ATAAACTCGT GATAAATTAT ATCCTGGGAT 21301 ATAATTTAAT GAGATGGTAA CACATTTAGT TTAAAGAAAT AAGTGACACT TTTTTTGTGT 21361 GACACAACTG TCTTATTCTT GGAAAGGACA AGGAGAGAAT GAAATATGGT ATGTCTTCAC 21421 AGCACCTTTC AAAGGGAGAA CCAGATTCTG AGGAGCTGGT CTCATGATGA ACTGTCAGGG 21481 TAAACCACAG TTCAGCAGCT GCAAATGTGC TTGCCAAAAT AGAGACAAAA AAATGTTTCT 21541 GAAAACAAAA TTTCACATAT GCCCTCCTCT GAGGTTGGCA TCATATCTTC CTGTGTATCT 21601 TGGGTGTAGC TTCTATCCTG CCAGAATTTA GACAGTAGAA ACCAAATGAG GTGATAAACA 21661 GAGTCATTTT GCAGAAGAGT CAAAATAACC CAGCAAGAAA TGAAACCACA AATGCCCAAG 21721 GAGTCATTCA TTCACCATTC AAAAGCTAAT AGAAATGAAC ACAAACTACT ATGAAAATTC 21781 ACCCAAGAAC TTAAAAAAAA AAAAAAAGGC TCATGGTGTT TAGTGTGATA GTATTCATTT 21841 TACCTTTGAC TTGTTCTAAA AACACACCAT ACTTCTACCC CACCCTTCCT CAGTGCCGTC 21901 ACACAATGGT TTCAGTGTGA AAAAAAAAAC CACGTTACTG GAAAAGGAGG GTGCCTGGGA 21961 CTTGCCACTC TAAGCTGGTA GTCAAGGGTC TTGAGTTCTA AAAGCATACG CGTTAAGAGC 22021 ATGATTCCTG GATCCAAATG AGTATGGATC TCAGCATTGC CATTTATTGT GACCTCAGGC 22081 TATTTTATTT CTCTGTGCCT GTTTCTTTAT CAGTAATGAA GATGTTCATA GACCCTTCTC 22141 CCACAGACTT AAAGGCATAT TTCATGATTT AAGACATCTA AACCATTCAT AACAGTATAC 22201 AACATGGAAT TAATATTTGA TAAAGGTTTA TGATTATTGT AACTAACTCT GTCACTTGCT 22261 CAAGGCCTAT AGAAAACTTA CTTAATTAGT TCAACTACAA AAAGAGTTTG AATGTGATAT 22321 CCACCAAGAT CATATTCAGA CCTAGAATTC TGTGATTCTT ATGAATTAAT ACAGCCTTGG 22381 TCAATAAATG AGAGCTGGGC AAATAATTCT TCTTTGCTAG CCCTTTCTAG ACCATCTGGT 22441 GAAGCATTCA AGACTTATGT TATTGGGGCC AGCCTTCCTT TCCAACTTCA ACTCCACAAC 22501 TCCTCAATAA GCCATGCGCT CAAGAAAGTT CTGCTCAGTG GCCCCTGAAA AATGCTTTCA 22561 TAGTCTCACT ACCATACCAC TGCTTACACA ATTTCCTTCC TACAGACTGC CTTCCTTTCC 22621 TGCTTTTCTC CATATACCTA AATCCTATCT ATTCTTCATA AGCAACCTTC TTTATAACAT 22681 TTTCTATAAC CACCAAGCCA AATGACCTTT TCCTTCTTAA ATATAGCACC CATTGGCCAT 22741 TACCATGCTC TGCCTTGTAT TTTTCTGATT TTTTTCTTTC TATATTCCTG TCTTAACTCC 22801 CCAGCTAGGT AATAATTTTC CTGAAATCAG GGACCAGGCT GACTCCTCTT GCTGTCTCAA 22861 GAAAGCTTAG CAGTTTCCAA CACAAAAATG TTCAATAAAC AACTATTAAT TGACTGATTA 22921 TAAAAAATCA GTGAACCATT AAACTTAATA TAGCAATTTG CTTAGCATGG TAATTAGCTT 22981 TTTGCTAATA TTCTTCCAGC CAGTCTCTCC TCCTGTGCCT CAAGGACATC TTAAAAAAAA 23041 AAAATCTAGT TGATCTGCTT CCATCTAGTG GCAATTAAAA CAGGTGGTTC CGGTAGCCAG 23101 AAAACAGCTC TGGGTAGATT GTGCCAGAAA ATACTTTCAC TCAGTAGGTG CGAGTTTGAA 23161 AGAAATCTTC ACATCTGTG GTTTCCTGCC ACAGACATAG GGAGACCAGC CCAGAGAAAG 23221 AAGCCTTTCC TCACTAGACT CCATTTGCAC TAGTAAAGAG AAGACAGAGT AATTAAAAAG 23281 AATAAAAAGA ACCTCCACTG ATCGTACATC CTCATCCAGT TACCCCTGCC CCACTTCTCC 23341 TTCACAGCCA AACATTTTAA AAGAGATGAC TGCTTGTTCT GTCTCTACTT TCTCATCCTC 23401 AGTAATGCTC AATGCTTGGC CGTCTGACCT CTGTCTTGAT GTCTGCACTG CAAATAGTCT 23461 CCCCACTGAC ACCCTTGTTG CATCCAGGGG ATACTTACTG GTTCTCTTGG CAATGTTTGA 23521 AACCGTTCCC CTTTCTTTGT TTCCTTGGCA TTCATTACCC CACACTCTTT CTCCTCTTCC 23581 TTCTCCCTGC CTGGCAACAT CTTTTCATTT CTCTTTCCCT TAGGTGACTT ATTAGATAAT 23641 GATGTTCCTC TGGCTCCCAT ACTCTCTCCC AGGTCCTCTT CCATTCTTAA AGCACTCACA 23701 CCCTCCCTGG ATGATAGTAC CCACTCCTGA GATGGCAGTT ACCTCCTGAA ATGTGAGGGA 23761 CCCAAATCCA CTTCTCCTGC CATAGCCTCT GTGCTTTGGA TAGGTCCAAT GAGCCACAGT 23821 GAATGATGTG CATACACCCA AAGCTCAGTA CAAAACTGAA CCCATGATCT TTACCTCCAA 23881 AACCTCTCAT TCTTTTATGT TCCCTTCTCA GAAGTAAACA GGACTACCAT CCGCCAGTTT 23941 CCAGGTGAGA AAGATGATAA TTTGATTCTT CTCTCTCACT TTTAGCCAAT TAACAGACAC 24001 ATTCAGTTAA TATCACCTCC TCTTATTTCA TGAACCCATT CTTACTACTA GTTCCCTAGA 24061 CAGGCGCCAT CGGTTTTAAT CTAATAACTG CAAATGCCTC CAAAACAAGT CTCTTTGAAT WO 00/09525 PCTUS99/17712 EPI-109 619 24121 CCAGGCTCAC CTGTCTCCCA CACTTGCCAT ACTGCTCTGC AGGGTGACCT TATAAGATGC 24181 CAGAGGTAAG GCTACTCACT GTTTAAACCC CTTTAGTGAT ATCCCAAAAG ACCTCAAGAT 24241 AAAGCCCATA TCACATGGCT TATACATTAG TTTATGATCT GGCTTCTGGT GCCTCATTTT 24301 TCCCCACTTT TTCCTTTGCA TTCTAAGCAA TGGCCCATAC TAAGTTTGTG ATTGGTAGGA 24361 TGGTTGCCCA AACCAGCATC CAATCCCTTC AGAAATCATC TCACTTCATT TCTAGCATTT 24421 TAAAGGAAGC TCAGTTGTCC AGCTGGGTAC TGAATATGTC ACCAAAGTCC TCCTTTCATA 24481 GTTTATTTTA CTTAAACTCT CCTTCCTAAA ATTCCAGAGC AAGTCACTAA ACCCTAGATA 24541 CTGAGAAATA TTTTTCCATC TTCATTTCTG CCAGGTGGGC CATCAACTTT CACATGTCTG 24601 CATCTCCTCC CACTGTGCTA TTTCTCCAGT AGAAGAAATT TGAGCTTCAA GACCAAACTG 24661 AAAAATACTT GCCTCCTTGG GGAAGCTGTA GGTAGAATTC ATGCTCCCTA TCTTTCCCAC 24721 ATTTCTGAAG GACAATGCCT GTTAGAGCAA TTGAATGCAA ATAGTCAATT GAATAAGCAT 24781 TTATTCATTT CTCAATAAGT GCTTGTTCAA TTGAATATTT CTTAAATAAT ATATTTAAGA 24841 ACAAGAAGAA CACACCACAA TGTTTTTAAC CCTCAGAAAA AATTCTGAGG TAATCAGAAA 24901 AATCTCCCTT TACATAAACT GCCCTTTTCT AATAGGGATT ACTTGTTCGT TCATTCATTC 24961 ATTCAGCTCC ACTAGCACCA AAAAGCACAG CTCTGAAAGG AAGCTAGTAG ATTTATCACC 25021 TTATCTGGTC ATTTGGATGA GGACCCCAGG TAAATAAACT ACTATGGGGT TAATGTGTCT 25081 AGCTAGAGCA GGAAGTAACT TAAGGAAGTA GAGAATGAAT CAGCAGATGT GGAAACTCCT 25141 CGCCACTAAT AAAACTTACC TTCTCTTGGA TTTCTTGCCT GAAAATAGAA AATAGAGAAA 25201 AGGCATTAGC AAAAATTAGA CAATTTAAAG TTTTTCAAGT AAGGGAGAAG GAAGACTCCC 25261 ACTCTCAAAA CTGTCTTTTG AAGTATATTA GGTATTTGTT AGGTGGACCC TATCTGTGTC 25321 AAAGGAGATT TGAGGAACTG GCTTAATAAA CAGTGGTAGA CACTAATACA GAACAGACAT 25381 GTTGATGCAG ATGCCTCCTG AGGTTCCATT CCATTCTCCG TGCTACTCAA GAAGACAGAA 25441 TTGCTAAATT GCCTGGTGGC AAGACCCAAT ATGTCCATTC AAGTGTTTAT CCCTTCCCAA 25501 TCTGCCATCT CATCCTACCT GCAGATTCTT CCCTTGAGGG ACAGCTGCTA ATACTGTAAA 25561 ACTATGTGCC ATTACAGCTC ACAGCATCAT CTCTATGAGA ATCCACAAGA GAATTTCACT 25621 TTGGTCTTGT TGGTAGGAAT TGTGCAGCCT CATCTGAGTA ACTAATGTGT TTTTATCTTA 25681 CAAACACAAG GAATATCACA TGGTTCTCCT TTGACTGGCT GTAAGGAAAC TCAGAGCTAG 25741 ATCTGAGACC CTCTCCTACC AAGTATATAA AACTTTGTGA CATACATTTT TGTGCCATAA 25801 CTTCAACCTT GGTTCCAAAT GATTTTTGTA CCCTAAGTTT AAATTTGGCT TTCTTTTTTT 25861 TTTTTTTGTA CTCAATAAAA CATCAAGCTC ATTTATTATT GCGAAGAGCG AAACAACAAA 25921 GCTTCCACAG CGTGGAAGGG GACCCGAGTG GGTTGCCCAA ATTGGCTTCT TTTTCTTACT 25981 TTTTAATTAA TTTTAATTTG CTATACTGAA CACATTTTGT ACTGTTCTCA CATTCTTTTT 26041 GAAAAAAGCA GAATATAAAT AAGTAGATAA CTTAAAAAAA ACTCTTTGAG CAGAAAGAAT 26101 CATTTGGGAG GCAATATATT TCAGTGGCTG TAAAGTGGCA TTCTAGAATC ATCCTACCCA 26161 GGTGAAAGCC CTATTTTGCC ACCTGTAGTG TAGTGTGTAT TTGAACAGCT ACTTTCTTTT 26221 CTAAACTACA ATTTCTTCAT CTGTTAAAGA GGCATAATAA TTGTATCATC CTCATTGGGT 26281 TGATAAAATA AAATATTTCC AAGTATTTAG TTCAGGTCCT AGCACGTAGA CAGTGTTGCA 26341 TTACTGTTTT AATCCTTTAA AGTATTAAAG ACTACTATTT GAAATCTTTT CTTCTAAAAT 26401 TCAGCCTGCT GATGACCAAG TGCACTTGAG CAGGGGGAAT CAAATCTGAA TTAATTTCAG 26461 ATTCTGGTTA GCTTCACATA AATATTTTTT TTAGGGATGA TGAACCTAAC AGCAATAGAT 26521 GAGTAAGAAT CTGTTCCTAC TGAGAGAGTT TCATTTTGAA GAAAAAGGAA CTAAGGGGGC 26581 ATGTGTTCAG TTTCATGCCC TGGTCTAACC CTGTGTGTTG GTTCTGGTGG GAAATTCTTC 26641 CAACCGAGGA AAAAACCAGT TCACAAATCT GAAGACCAGT GATTTTAGAA GATGTATCTG 26701 GACTGGAGTC TAATCTCTGA CTCTGGGTCC TGCTGATATG GTATTTTTGA GATTTGGCCT 26761 AAAACATCAT TGCCCTGGTT TCCTTATTTA CCAAACAGGG CCAATGGTAG TGACTAATCA 26821 GAAAATGATA ATGCCTGGTG CACAAAATGT GTCTAGATGA GCCCATGCAC AAGGACACAT 26881 GTTTCTGGAA CTGTTCCTTA TTCCTTTCCT AAAAGAAAGG AGGGAAAGTC TCCATACTAA 26941 GACTACTAGG GCAGGGGACA AAGTGCTAGA GTCAGAAGAT TCATCTGAGG ACAGAAGAAT 27001 AGGGGTGAAG GCTCTAGTCA CTTCATTGGC TACCATGCTC TAAATAGTTA CCTGTGCCCT 27061 TTTTCTAACT ATTAGAACCC AAAAAGCCTA TAAATTCTCT CTCTCTCTCT CTCTCTCTCT 27121 GTGTATATAT ATACATATAC ACACACACAT AGACACACAC ACACACCTAA ACACACACAT 27181 AGAGATTTAT GACTTTTTAC TTTTATCCTT GTAAATGCCA TTAACTATAT TTTGTCTTAG 27241 ATTTAGCCTG GGAATGTAGC CATTATTTCT ACCATTGCCT CCATAGGAAA AATACTCTTC 27301 ATGTTTTAAA GGACCAACCT ACAACTAAAA TCTTTGGAAA GCAGAATCAT TTGTAAGTTG 27361 GTGAAAATGG AAGATGTTGT TTTATAAATG AAGACTTTTT TTTTTTTTTT TTTTGAGACA 27421 GGGCCTCACT CTGTTGTGGA GTGCAGTGGT GCTGTCATGG CTTACTGCAG CCTTGACCTC 27481 CTGGGTTCAA GTGATCCTCC CACCTCAGTC TCCTGGGTAG CTGGGACTAC ATGTGCATGC 27541 TACCATGCCT GACTAATTTT TTGTATTTTT GTAGAGATGT GGTTTCGCCA TGTTGCCCAG 27601 GCTGGTCTTG AACTCGTGGG CTCAAGTAAT CCTCCTGCCT CAGCCTCCAA AAGTGCTGGG 27661 ATTAGAGGTG ACAGCCAAGG TGCCTGGCCC ACAGATGAAG ACTATTTAAT GTTATCTTAA 27721 AGATACCCTA AGCTTCCTAC CAAGCCAGTG ATCTTTTGGG GCTTCTGTTT TCTTTGTTGG 27781 CATAACTGTA ACTAGCCTAA CTGCCCGTTA TCTGTTTCCT GTTTGCCCCA CACTGATTCC 27841 CACAGCAGTT TTCAAGTTAT CGGTTTGAGA TCTTGTACAG AAATGACTCC AAGGTAAAAA 27901 ATTTAAAAAC AACCCCTCTA ATTTTTTTAC CCTTGCTTAT AAAACAGCCT TAGCCAGCTA 27961 ACCCCTCACT ACATGCAAAT GAGTTTGATT CTATTCTTTT GATTCTACAA ACACTTATTA 28021 AAAGATTTTA GAATTCGGAA ATAAATAGCT TCCTTATTAA GGTGACTTAC AGCCCCAAAG 28081 TCCTTAAAAT TATTTAGACA ATAGCCACCT TATCCCAGGG GGCAGTGTGT AATAACCCAC 28141 CCTGTTCTCT ATCCGTCAGT TCTGCCATCA TCGCCCAAGG TAGGAAGAAA GACAGGACAA 28201 CCGGGGTCAA GATTTGAAGT CTCAATGGAA AGAATAATCA GTGGTTGGAG AAAACTGTCA 28261 TTCTTCTTTT GCCTTAATGC AGTACTTGAT ACTTATACTT AGTACTGTAT AGTACTTAGT 28321 ACTGTATAAT ACTATAAGAT AGTGAGATTC AATCAGCACA GAATTTCTAA TAGCAAGGGC 28381 AGAGACATTT TAACTGCTCA GTGCTCTCAG GTTATACATA GCTAATGAAG TTCTTGCATA 28441 TCAACAATCC CCACCCCCCT CACACACTTT GTCTTTCTGG ATTGGTTAGA AAACTTACCT 28501 AGCGCCCACT ATTCTCAAAT TTAAATGAAA GATAAGATCA GAGTGGCACG CAATTAGGGA 28561 CTGATAAATA ATATTTTTGT AATTGCCAGT GTAAATGGAC AGGGGGCAAC CTTTACATAC WO 00/09525 PCT/US99/17712 EPI-109 620 28621 CATATTCAGT GAACAGAATA CGTACTAACT AATTTGATGG AAGGAAAATT AAAATGACAA 28681 TCAACTGAGC CCACAGAAAG GCAACACAGA GCAGTTGGTT AGCAATTGTT TCGAGATCAT 28741 CCCTGAACTT GAAACAGGTA TATCTTTTTT TTTTTTTTTT TTGAGACAGA GTCTCACTCT 28801 GTCACCAGGC TGGAGTGCAA TGGTGCGGTC TCAGCTCACT GCAACCTCCG CCTCCCGGGT 28861 TCAAGTGATT CTTCTGTCTC AGCCTCCCGA GTAGCTGGGA TTACAGGTGC CCGCCACCAC 28921 GCCTGGCTAA TTTTTGTATT TTTAGTAGAG ACAGGGTTTC ACCATGTTGG CCAGGCTGGT 28981 CTTGAACTGC TGAGCTCATG ATCCGCCCGC CTCGGCCTCC CAAAGTGCTG GGATTACAGG 29041 CATGAGCCAC CACACCTGGC CAAAACAGGT ATATCTTAAA AGCTGCCCAA TGTCCATGAA 29101 TGTTACAGCC TTGAATGGTT CTTCCAGGTG AGTTTGGCCA AATGTGGCAC CATACACCCA 29161 AGGCCTGCTG CAGGCTAGTG GGTTGCTCAC ACTTTAAAGC TGAGACACAC TCATGCCTTA 29221 AGGTAAAGGG AGTGATAATC TGGGCAGCAG ATGTTAACTT CTCAAGGCAG TCCTCCTTCT 29281 CTTTTCCTCT CCAGTGACGG ATGGTTGGAA AGCATATATG GTGCATTTGG TTAGAGCTGT 29341 GGCCTTGGTG AATAGATACT TGGGAGAATA CATGGGAATT TCTCCCAGGG TTAATGCAAT 29401 GCCCATGTGT TGGGAACCAG GTGACTCTTG AAGAGGTCAG GTATTTGGGA GCAGTGCCTT 29461 GAAACCTTAG TGGACATTAG ACCCACTTCC TAGTGGAATT GTAGCATTGA AATCCAAGGC 29521 ATGTAGGCTC TTAGAGGACA GAGATAGTGT GTCATTTTTT CAGAATTAAT TAAGAGCAGG 29581 CCAGGCGTGG TGGCTCACAC CTGTAATCCA AGCCCTTTGG GAGGCCAAGG CAGGCAGATC 29641 ACGAGGTCAG GAGATCGAGA CCACTCTGGC TAACACAGTG AAACCCCGTG TCTACTAAAA 29701 ATACAAAAAA TTAGCTGGGC ATGGTGGCAC GCTCCTGTAG TCCCAGCTAC TTGGGAGGCT 29761 GAGGTGGGAG AATAGCTTGA ACCCAGAAGG CGGAGGTTGC AGTGAGCTGA AATTGCACCA 29821 CTGCACTCTA GCCTGGTGAC AGAGTGAGGC TCTGTCTCAA AAAAAAAAAA GTATTAAAGA 29881 ATTACATAAG AGCAAAGAAC CATTAGAATA TCTCACTTAG TTGTTATCAG CCTAGCAAGC 29941 TGCCTTGAAG GTAATAGACA TTTTTAAAAG TTTATCAGAT GAAAAGCGAA AATCAGCCAA 30001 CCTGTTTTAA TGAAGGTGTG TCCTGGGCTG ATTTACATGT CTCCAGGGAC TGATGGCTCT 30061 AGAATGTAAA GCTTGGCATC CTGCTTGTGT TGAATCTATC ACATTTAATT TCCTGTGGGT 30121 TTCTTTTTTT TTTCTTTTTC ACTTTAAAGT TGTGTTCTTT TCATGTGAAG TTAAACTCAC 30181 ATACCTTTTT TTAATCTCCT TGCCAGCCAA ATGATAAATG CCAACCCAGA GAATGCAGTA 30241 ACCATGACTG CCACTGGAAT GAAGAGGGGG TTATAATCAC CCTCCTTAAT CATTGAGAAA 30301 CTTTTGTCCA ATTCTGAAAG AGAAATCAGT AAGGCACATA GCATGAGACC ACCAGCATTA 30361 TTTCCTTAGT CTATCTCATG ATATTTGACT TTTTTCCTCC TTACATCTCC CAGTAGTAGC 30421 CCATTTGATG CCATTTGACA GATGAGGAAA CTGGCATGGG AAGGCCCCTG ATGAGTCTAC 30481 AGCATAGGCA AAGACTGGAC CAGCCTTGCT AGTCTAATGC CTACAGAATC TCAATGCCCA 30541 GATTTGTGGT TCATAGAGTT CCTGAAAATG CACCTAAAAA TGTTGGCAAG AATGGTCATC 30601 GTTGTATTTA GCTCCATGGA CTTGTTCAAT GACTGGAACT CTGAAACACA GAGAAGAGCT 30661 AAAAGCCTAA TACAACTTCA GGAAAAATAA AAGCCAATGA TCTGAACTGG ATAATTCACC 30721 AGTCAAAGGA AATCATTAAT GCTTTTACTT TAAAGCAGTT GTGCAAAAAT AAGCACTTGA 30781 TTTTTACATG CCAAGGACCT GCACTAATTT CTTTCCAATG CAGTAGTTAC CACTTCCCTC 30841 TACTTCCTTC ACGAATAAGT AAAAGGGCAT GTTTAGAGAT ACTCTTGTAA GTGTAAACTA 30901 AGTTCATTTG GGAGCCTCTA TTTGAAAATA CTGGTATAAA AAAAAATCTG TCTCCTGATA 30961 CTAACATTTG AAGGAATCTA CTTTTTTACA TATTGGCAGA GGGTCTGATT CTATCCTTAG 31021 TTCTTCCCAT TACTTTGATG AACCTTTTCA AGGTGATTTG ATCCCCACAC CCAAATATAT 31081 GATTGAGAGA AGGCTCAAGT TCCCAGGAGC TCCAGACAGA AGGTACCTGT TGGCTTGATG 31141 AAGATGAGGA GGAAATGAAC ACTAGCTAGG CCTTAAAGGG AAATGTCTCT GATAGGCCTA 31201 ATACACAGTC CTCTGCTAAA GGCCTCCCTG CCTCTCTCTG CTCATCCACT CTACTCCCTG 31261 GCCCTGGGCA CGCAGCACAC AGAGATCAGC ATTTCTGACA GCTTCTGTAG ATCCTACCAT 31321 TTAAAGACTT TTGTCATCCA TGCAGATAGT CTCAGGAGCA GACACAGGTA GCTATTCTTT 31381 CACATGCTAG CTTAACATGC ATTTGCTTTA GCACCTATTG CCAGGCACTG TGTCAGGTGG 31441 AGGGTATACA AAGATGAACA AGACATGATT CTTCTCATAT ACAGATAGAT TTTGGAGGCA 31501 TTAGCTTAGT GATGATTCAG GAGTATCCAT TATTTGGGGA AGTAGGTGGT CATTAGTGAC 31561 CTTTTACAGG CATTTCAATG GCCTAACAGA GATGTTAGAT TGTAGTGGAA TAGAAGAATG 31621 GGTAAAAAGT AAATCAGTGA GTTCAGATTT TAGGAGTTAA GATGGCAAGA GGTGAGAACA 31681 AAAAAAGGAA ATGATTGTCA TTAAAGGAGG AGGAAAGACC AGCCAAAGAT TTTACAGTGA 31741 GTTAAGCATA CAAATTTATT TCTAGGCCAC ATATTCTTAG CAAAACAACA TGTAAATGTT 31801 TATGTATGTC TTTCCTCATA TCTGCTCATC CATCAGCTCC ATCGTTAAGA TTTCAGTTTT 31861 CCAGGACAAA CTTACTCACT TTGACATATT GGACTAGGAT TTGACCAGAT TCCAGATGAT 31921 TCACAAATGG TTTTCTTCTT CCCAATTAAC TCAGTTCCTT CTGAGCAGAT GAAGGTACAT 31981 GCAGAGGTAA AGCTGAAGCT GGCCAGGGGA TGGCTACAGT TCATGATCCC CAAATCTGGT 32041 GCTGATAGAG GCTCACACTG AATCACTTCA ATGAAAAAGA AAAAAAAAAA AAAGACAAAA 32101 CAGTATTTCT GAGTAGAGAC CCTCCCTTGA GCAAAGGATT TTTAGCCAAA GCTGCCTGAC 32161 TACATTACTT GTGATATTGC TTCCAGGCTT TATTTTCTTG AGAATGATGG TGGGTGGTGA 32221 ATGAGAGATG AAGGCA.GGA AGCATTGAAA GCTGTGGGGA GAGGAGTAGC TACTCCAGGC 32281 TGCTGCCCTA GCTAAGGTGA CCCTCCCCTT CTGCTGGAAG TACCATGCCA TATGGCCTCT 32341 GCATCAAGGG CTCTTATGGG ATATTCTCAG AGAATCTCTG CCGTTTCATC TGTTCTGATA 32401 TCTACCCAAG CATTTTGAAA AACATCCCAA TTCACTGAAG CAAGTCCAAC TTCCGTAAAT 32461 TCCAGTAGGT GGTTGACAG TTTTATAATT TCAATAAGGG ATTTTGATAG CACTTCTAAG 32521 AATTAAACTA CTTAAACTAA TGCATCAGGA GCATACTTGT AGAAAAGTTA ACCAAAACTT 32581 CGTAAGTTCA GATGACATTG GTTTTCTCCC ATATGGAGAT AAGGTTGGCA GTTAAAAATG 32641 AA.AAAAAAAA AAAAACCTAC CTTATTTCAA ACTTGAAAAG ATCAAGAGAT TGTGTTTTTG 32701 TTTTTCAGTT GTTATTCTCC TAAAAGTTTA TGCATGAGGA AAAGTAAAAG TGATTTTAAG 32761 AATAAGCCAA ATAAAACAAC CAAGAAAGAC CTCCACTACC CTGGGAAGGA AACTGGTTGG 32821 TATTAAGTAG GACACCACAT AAAACAGGTG TTATTGAGAG GAGAAGAACC AAAATGTAAC 32861 TGAGGTTCAA CAAGACATTA TTTATGCAAT GGCAATGAGA AAAATAAAAA ACACAGTATA 32941 ACCATGCTGT ATTGCTATAA GTCATGTTAC ACACTGGGAG ATGGCTTCAG GGGTATTTGG 33001 TTTTTACTTT TTGTTTGGGA GGTTTTTCAA AAAAATTTAG TTAGAATAAG TCCTTTGAGA 33061 AACATCACAG TAGGTTAAAC AAAGTTAGGT TAAATTAGGC TCCTAAGTTT GACTTCTCAG WO 00/09525 PCT/US99/17712 EPI-109 621 33121 CAAACTTCTA CTGAATGTTC TGACTGTAAG CCCAGGATTG CATGACAAAA CCTCTAGTCT 33181 GAAGTTACTC ACCTTGACAG GTTGGTTCTG GAGATGACCA GTTTCCAAAT GGTCCACAGG 33241 TGGTTTCTTC AATCCCAGTT AAGTTTGTTC CTTCAGAGCA GCTGAAGGCA CACTGTGAGC 33301 TGAAGCTGAA GTTTCCCAAA GGGTGAGTAC AGTCCATGGT ACCCAGCTCT GGGGCCTCCA 33361 AAGGCTCACA CTGAATCACT TCAATAGGGA AAGAAACAGT ATGGGGAAGA GTTAAGAGGA 33421 ACTGACGCCT GGATTTGAAT CCTAGCCCTG CCACTTGATA ACCATGTGCC TTTAAACAAG 33481 GTTACTTGAA CCCTCCAACT TCAGTTTCTT CATCTATATA AGAGGAATAA TGAAATTGTG 33541 TTATCTTTAT CAAATTGATA TGGAAACTAA ATGTAATTCA ATTAGCATAA GTCAAGGACC 33601 TTAGAACAAA GCCTGACTCA TCAGAAATTC TAAGTAAACA TTAGCTAGTC TTCATATTAT 33661 TATCTTCAGC ATTATCTGTA GTGAGAATCC TTAAAGCCAA ATAGGTGTAA CTGGGAATGA 33721 CCAGCTTAGT CGGGAAATAA CTATCACATC AGAGCCCCTG AGTCTACTAG AGTATTGGGA 33781 GCAAGATGTT CAGAGAAAGA GTGGGTCTCC ATAATAAGCC TTCTTTGCAA GGAGAGAATA 33841 TAAAAGTCTA GGAAGCATTT TGACCTCAAT TCTGTCTTCT ATTCTAGCTC AGTTCCAGAA 33901 TTTTAACTCT TTTGATTTTG ACAACCCTCT CCAGAAACTG TATCTATTTC CCTGTTCTGA 33961 TTGGTGGTAC AATAGGTAAA TTTAAGACTT GGAAATCAAA GTTTTCACAT TTTAGACCCT 34021 GCCATGCCAT TTAGTAAACA GTACAACTTT CATGTCTTAT TCCTCATCTG TCAAATTTAA 34081 GCCATTATTG CTACCTTGCT CTAGAGACTT CAAGGAAGAA TGGACTCAAG GAATCAGAAG 34141 AATTTTTGTA TTTGGAAACT ATATGAGATG AGATTAGGGA GAAACATGGG AACTAAGAGA 34201 AAATGTTATC TTTTTTCATT GATTTAAAGA GTATCTATTA TATATCAAGC ATTACTCTGG 34261 GGCTTGAAGA GCTTAGATTT CACCCTGTAG GACAAAATGG TAGGTAGAAA TTAATGGGTG 34321 GATTGTCATG TATGTGTGAT GTGTTTTAAT TGCTTTTAAT TGATCAGTCT CCCTGTAGTA 34381 TGAATAATGT ATTTGAGGGG AGCTAATTTA AAATTGTGGA ACTCATCTAA TAAACTATTG 34441 CAAGAATCTA GAAGAAAGAT AATGACGGCA ATGGTAGTAG AGTTGACAAG TGGAAGACAA 34501 ATTAGAAAAA CACTAAGTTG TAAAAATTGG TAGAATGTTA CCCTGCATAA ATGTTGGGGG 34561 AGTTAAGAGA GTCTCATACC AGGGTGCCCA TGTAAATGGT GATTCCACAT ACTGAGATAA 34621 GAAATACGAA GAGAAAAGCT GACTGGGAAC AATTGGTTTT ATAGTCTTTT AAACATCCCA 34681 AAGGACATCC TTAGCATATT TGAGTTCAGA GCTGGAGATA GGCTTATCAG TCCAAAGATC 34741 ACATAGATTT GTGAGTCCGC AAAAGTCAGT AAGTTTGACC AAAGGATACA TGTAGATTAG 34801 AGTCAGAAGA GCAATATACA AAAGACAAAA GCTGAGAAAT TATAGTAGTT TATGGTCCTG 34861 GATAAGTGCT CATGAAGGAT CTCAGGAGAA ATGATCACAG GTAGAAAGAA TGAGAAAAGA 34921 GTGATATGAG AGAAACCAAG ACAAAGAAAA GTAAAATGTT AAAAATGAGT GAAATAGGCA 34981 TACCAATAAT TAAAAATGAG TAAAATAGGC ATACCAATAA CATAAGGGTT AAAAAATAGA 35041 GTTCAAAAAT GGGGTGAGGG TAAAGTATTA GGAAGGAGTC ATGGCCCAGG GATCAAGTGA 35101 AATGAGTTAG ATCTATAGAT CTATTTCAGT TGGTTGACAT TTAAATGTAT TTTGGTTTTA 35161 ATTCTTTATT GTTTACAAAC ATTGCTTTTT TAAAAAATTA AATTGTCCAA TTCAATTCAG 35221 GCTCACAAGC AAGTGCCTCA TATATACAGG CATTTTGTGG ATCCCAAAGA TGCAATGATA 35281 AATAGGACAC TTACTGATCT CAAGAAGTTT TCAGTACCAG AGGAGACGGA CAAGTGAACA 35341 GATGACTTCA ACATAAGTGG GAGAAATGAG GAAGAAATAT GTGGAGCTAT CAGAACTAAG 35401 AAAGCTTCCT AGAAGAAACT GTCTTTGAAC AATGTCTTAA AGATGACATG TTTTTTGGCC 35461 ATGTGCAAAA TGAGAGAGAA GGCCACCAGC AAAGTCAGTG TGCTACAGAG CACATGTGTT 35521 AAGTGTGGAG AACTGCAAGA AGGAAAGGAA CTACTAGAAG GAAAAAGCAA GATACTTTCT 35581 GGGTAACTCA GCCTCCTAAT GATAAATGGC ATAGTTTCTT CCAGACCTTA GAGTTCTAAT 35641 TAATCTAACA AGCTCATTAG ATCGTGAGCT TCTTCAGAGC GGGAATCTAC CATGCTAATT 35701 CCTTATGGTA ACCCTGACAG CTTTTATCCC AACACTGTGC TTCTTGTGGT ACTCAAAAAG 35761 ACTTGTTGAG AAGTGAGTCG AAACTTCATG CTGACTTATG AAATCTTTAC GGAAAGGTAA 35821 CAATATTGTG AAAGCAGAGC TTTCTGATCA AAACTTCCCA TTTCTCAGAG TGGCTAGTAT 35881 CATTTTGTTC CAACCAGCTT CATGATAAGC TATAATGATT CCTGTGACTT TACCTAAGAA 35941 GAAGCAAAGA AAGGAAAGAG ACTTACCAAA CTGACACTGG GGCCCATAGT ACCCCACATC 36001 ACAGTTGCAG GTGTAATTAT TGATGATTTC TACACATTCT CCATGGCCAC TGCATGACCA 36061 GGGCTGGCAA GAAGCTTTAA GGAGGTCAGA AAAAAAATAT TTTAATGTGA TTACATTTTA 36121 GTACTCAAAG TCATTTCTTT AGACATAGAT AACCTTTTGT CTGAGATGAT TTAAATAATC 36181 AGGAAAGGTT TATTTGTAAA TTCATAGCAT AAAAATCATA TGCTAAAATT TTTACGTATA 36241 AAATACACTA AGCATATAGT CATAGGCATT TATTTGCTTT TGGAATGAAA TTACCAATAC 36301 TAATATTCTG TAACACTTAT AGGAAACTTA GTGGCATACC TTGAAACTCT TGAAATTACT 36361 TGTTTTTAAT GAGTGAGAAG GTTAAATGAT GACCTGACCT CAATCATTTC TGCATGCAAT 36421 TATTTCTTGG CAATCCCTTT CTTTATAGAA ATCAAAGATT AAAAAGTCCA AATTTGCTAA 36481 AACGGTAGAG TCCAATTTAT AAGAGACCAA ATTAACTATG GTTCATTATT AAAACATCAC 36541 TTGGAAAATG CTGGCTGTTT TGGAATTGTA GAAGATTTTA CAGAAATATT CATACACCAA 36601 AGATAGTGCA ATTTTTATAT AAAATTATAT AAGGTTAGAC CAAGAAGGAA GCACGCAGCA 36661 CCACACTCTC TACTTCACAA TGTGAAAACT GAGGTGATGT GAGCCTAAGT TTCCAACTGG 36721 CCCCAGCTGT CAGCTTCTCC TCCCCTGCCT TATTATCAAA GGCACTGATT GTCTAGCTCT 36781 TCCTCTGTAC TTCCTACGTA GATCTATCAT TTTGATGTAA CTTGATTTAG GGGTATAGCT 36841 TTTGTGCACA GGGACAAATC TTACACACCA AAAATTCTTA GGAGTGACAC GATGCAAGAT 36901 TATATAGAGG GCTAGATGTA TTTTAGAATG AACCAGAAGC TGTTCTCATC CCCCCACCTT 36961 TCCATGGGGT AAATCTGAGT ATTCTCTTAA CCGTGGCCCT TCCTGAGTCT GAGGCAGCAT 37021 AGCCGTCTTG TCACTCCCTA CCTGTGTAAC AGAGGGCTGC CTTTAGTTTG TGGCAGGCGT 37081 CATCGTTCCA TTTGCCTGCA TCTTTGTTTC TCTTGATATA GATCTCCACG CAGTCCTCCT 37141 TGTTCTTCTT GTTGTTGGGC TCACCATCTC CCCAGTTCTC TGCTTCTTCA GTAAGAGATT 37201 TGTTGGTTCC CACCCACGTC CATATTCCTC CTATCTTCCG GATTCCTATC CAGTAGTAAG 37261 AACGACTGAA AGGCAGAGTC TTCTCCAGAT ACTCAATTTC CGCCTTGTTT TGTATGGCAA 37321 CTAAATCTGT GTAATTGTCT CGGCAGAATC TTCTAGCCCT TTGCCAGTTC ATGGGTTTTT 37381 CAGAATAATG GTAAGTCCAG CAGTCGGTTC CATGATGTGC CAGGAAATCT GCAAGACATC 37441 AGTGTGACCT ATGCAGACTT ACATAATGTT ACAGCTAAAA AGAACCTAGC ACTACTCCAG 37501 GCTGAGCTAG ACACTTAGAG ATGAGGAAAC AGAGCCTAAG AGTGTATGTG ACCATCTCAG 37561 GATCACAGAA TAGTTGTTTG CAGATTTGAA GTAGAACCTA GACCTTCTGG CTTGAATATA WO 00/09525 PCT/US99/17712 EPI-109 622 37621 AGATGCTTTT ATCTAAGGTT CTATTTGAAA CAAATTTAGT GGTTTTCTAG GTTTATTTTC 37681 TTATTAATTT TTTTCTCAAA ATTATTTCAG GTGAAATTTA ACCAACATAT TTTAGACATT 37741 CATATTTCTT TTTCTTTGTA GCTGTTAATG ATTTACAACT AATTACCGTG TAATATCATA 37801 TAACTATACA ATTTACGTAT ACTTTTTAAT CCTGGAATCA TTTCTTGAAG GCCAACACAT 37861 ATGTACCTAT GGGAGAAGCA TAATAAGGAC AGGAAGAACA GTGACATACT TTTAAGTAAC 37921 CTCTTTTACA TAAAAAACAT TTTATTTTAC CATAGGAAGA ACTGCTTCTG GAAAAGCCCA 37981 ATATACCACT CAACTCTTAT ATATCTAACT GTATAATTTT TAAAAAGAAC AATTTACAAA 38041 GCCAAATGGT ATAGGATTAT GAAATTCATT AGATCATGTT CTATACACAA AGAGACTCAA 38101 CTGATGATGT TTAATAAACA TATGGACCCA TCAAATATGA GGGCTTTGAA GATATCTAAT 38161 TAAACACATA ATTACACAAT GACTTCATAA TAATATATGG CATTCTAAGC ATGGTATGAT 38221 CTACATGAAT CACTATTTAA TACAGTAAAG AAACAGATAT AATTGATGGT AAAGAGCATC 38281 ATAAAATAAA CATTTTGAAC AGAGTTTTGA ATGAGCATTC CACTAGAATG CAAGTTCTAA 38341 GAGGGAAAAA ACTGTTGTGT CCACTGCTGT ATCCTTAGTG CCTAGCATAA ATTTCACACA 38401 TTGTAGGGAC TCAGAAAATA CCTGTTGTAT GAAAAGAGCA CTAAGTTTCT ATGTGACACA 38461 GTGCAGACAT GGCATAAGGA ATGTGTGAAC GGGAGAGTTA GCATGTTTGC TTGGCTAGAG 38521 CTGAAAATCC AGGCTAGGGA GAAAGAAGAC ATTAGTTTAC TTAGGAAATG AAAAACCAAG 38581 TTCAAAGCTA TTGCTGGAGA GTCTTCAAGA ATCAGATATA AAATTTGTCA CAACAATGGG 38641 AGAAGGACCA AAAAATGATA AACCCCCGTC CCTTAATAAG CTCGTATTGT AATTGTAGAA 38701 ATGACATTAA TGTACACTGA ACTATGAATA AAAAATAGAA AATGAGGTGC TAAATATTTG 38761 GTACAGATTG TAAGTACCTT AACAGAGATT TCTTAATTAA CATTATTCCT TTATAATTGA 38821 GGGATTTTGT GGGGTTATTG GGATTTGAAC TCTACAGCAT GGGCTATTAT AGGTTAAAAA 38881 TAGTGTTCAG GAGTTTCTGG GGAAGAACTA AAGGTAAGAA GAAAAGAGAT GTTTACAGAA 38941 GGGATAGAAT TAACAGCTCT GTGAAATAAT TTTCCCTTAG ACTATGTATA ACTAGTGGAT 39001 ATTTAAGAAA AATGAATATA AGTAAAATAG ACTTAGCGAT ATATAAATAT CATAACATAC 39061 CACAACAGAG CATTGTCCAC CCCCACAACT TGAAGATGTT CCATAAGTCC CTCTGGGTGC 39121 TCTGACATTT CCATGGAAAT ATCTGCAAAT GAAATACAAA ATTATATTTA GATGTATACT 39181 CTTAAACCAC ACATTTATAG CCTTTGAGGT GGTGCTTACA ACTTTCTTAA TAATCAGAAT 39241 AAAACACATA TGTCTACTAA CCCTGTCTGA GGTAACAGGT TTCTCAGACA TAGATGAAAA 39301 ATTACTTCAA ATTTACATCA GAACTGATGC ACAGTTTTGT TTTGTTCTAT TTTATTTTTA 39361 CGCTTTAGTC TCAAGTTGCT AATCGGTACT GCCCTGAATT TTTTCTATGG TTTGGTAATT 39421 TTTATACCTG CTTTTCTGCT GAGCTATTAG ATAAAACTAT TTAATATTTA CTATGTATAT 39481 TTTTTAAAGT ATTGTTGCTG CTTAATTAAC TATTGATGCT TATATTTAAT GTTATAGCCT 39541 CACTCTTGAT CATAATGGGT CAATGCCTCA AATACCTAAA AAAAAAAAAA ATTAGATAGC 39601 CAGACACCAG GAAAGAAAAG TATTTCTTTT TTTAATAAAA AGAAATACCT TTTTGAGCAA 39661 CTGAAATGAC AAAGTCACAA ATTTCCTGCA CACCTTAAAA TATACTTAAT GTAAATGACG 39721 AGTTAATGGG TGCAGCACAC CAACATGGCA CATGTATACA TGTGTGACAA ACCTGTATGT 39781 TGTGCACATG TACCCTAGAA CTTAAAGTAT AATTTTAAAA AAATTCTATC TTCCAAAGCA 39841 TATCACTTCT CAGGTAGACA CAGTGTTTAT TGCAAAAGAT CTGATTTCAA TAGTATTTCT 39901 TCAAGAGTCT CCCCAGAGAC AAAGTCAAGA AGAGGAAATC AGCATATCTG AGAAGAAAGA 39961 TTTCAGGATC ACTTTTTTTG AGGGTCTGAG AAAATGTTTA GTTTCTATAT TATTTAAAAC 40021 CAGAATTGAA ATGGGGTGAT TCCTATCCTT GCCACCTGCC TCTACAACCC CAAGAGTTTC 40081 TATCTGAGCA TCTAAACGTC TTTTAGGCTG AAAGGCTCAC CATGGCTTTG CTTGGTCCTT 40141 CTCTAGTTCT TCTGCAGCCC ATTGAGCCTC TTGACTTAGC ACAAGGGTCT CAGGTCCTTG 40201 CCCAAAGGGA GTGTGCTGTG CTGCAGGTAG ACTGCACTGA ATGTCAACAG AAAGCCTTGC 40261 TTTCTTTCAT TTCTCTAACC CAGTCTCACA TCCTCCTCCT CCTCCCCTTT TCCCTCCCCT 40321 TCCTCCTGCA CTTCTCTTTC CTCTTTCCCC ACCCCTTTCC TAGACTGGCC TCTATTGCCT 40381 CCCACTGAGA CAAAAATGAA CTGCTGATCA GAAAGTAATG TGACTAGATT CTCTCTTCCT 40441 TCCCTCCTTT CTATCCTTCC TTCCATTCTC CTATGCATCT TTCCTTACCC TCCTCCTCCT 40501 TCACTCATTG TTGTTGCTGT TCTTCTTCCT CTTCTTTTTC CTCCTGCTCC TCTTCTTCTA 40561 CTTGTTCTTG TTCTTGTTTT TGTTTGGTTC TTGTTCTCCT CTTCCTCCTT CTCTCTCTCC 40621 TCCTCCTCCT TCTTTTCCAC CACCCTCCCC TATCTTTTTC ATAAATGCTA AACTAACTCT 40681 TGGCTACCTG TGGTAAATGG CCCTTGGAAA TTGCAAATAC TACAAATCAA AACTGCATTT 40741 CAGACATATT TATGATGTTT GCAAAACTTC AGTAGAGCTA AGCAGTGGAC TTGACTCGTT 40801 TCGGTTCCTT CACCTCCGTC TTTCCTTGCT CACCACCTAG TGGACGTCCT TGTTAGTGGC 40861 ACTTCCTGAA GTTAACCCCT GAAGAGAGCC CATGCTCTCT AGCTTTTCAC CGTGTAGGTT 40921 TGGGAGCCTA CAAGTACCTT TAATATTCTT GGACTATAAA ATGAGATGGT TTTATAAGAC 40981 TGCATGTGAA ATTAGGACCC ATATGATGAA GGACAATAAA AAGGAAGACC CACTGATGTG 41041 AGTCAATGAG TCAAATGCAA ATCAGATTTG CATTTTTAGG AAAATAATAA TAACAACAAC 41101 AAAACTCTG AAGCTCAGCG CCCCATATTT ATTATATTGT TTAATCTTTA TAACAGCTCT 41161 CTGCTATAGA TATGATTATT ATCCCCATTC TAAAGAGTCT CAAAGAGGTT AAGAAACAAA 41221 TTCAAAAACT AGCGAAAGAC AAGAAATAAC TAAGATCAGA GCAGAACCAT AGGAGGTAGA 41281 GACACGAAAA AGCCTTCAAA AAATCAATAA ATCCAGGAGC TGCATTTTGA AAAGATTAAC 41341 AAAATAGATG GACCACTAGC TAGACTAATA AGAAAGAAGA ATCAATAGAC ACAATAAAAA 41401 ATGGTAAAGG GGATATTACC ACTGATCCC TAGAAATACA AACTACCATC AGAGATTACT 41461 ATAAACATCT TTACACAAAT AAACTAGAAA ATCTAGAAGA AATGGATAAA TTCCTGGACA 41521 CATACACCCT CCCAAGACTA AACCAGGAAG AAGTCAAATC CCTGAATAGA CTAATAACAA 41581 GTTCTGAAAT TAAGGCAGCA ATTAATAGCC TACCAACTAA AAAAAGCCCA GGACCAGATG 41641 GATTCACAGC CAAATTCTAC CAGAGGTACA AAGAGGTGCT GGTACCATTC CTTCTGAAAC 41701 TATTCCAGAG AATAGAAAAA GAGGAACTCC TCCCTCACTC ATTTTATGAG GCCAGCATCA 41761 TCCTGATACT AAAACCTGGC AGAGACACAA CAAAAAAAGA AAATTTCAGG CCAATATCCC 41821 TGATGAACAT CATTGCGAAA ATACTCAATA AAATACGGCA AACTGAATCC AGCAGCACAT 41881 CAAAAAGCTT ATCAACCACA ATCAAGTTGG CTTCATCCCT GGAATGCAAG GCTGGTTCAA 41941 CATACACAAA TCAATAAACA GAATCCATTA CGTAAACAGA ACCAATCACA AAAACCACGT 42001 GATTATCTCA ATAGATGCAG AAAAGGCCTT GGATAAAATT CAACACCCCT TCATGCTAAA 42061 AACTCTCAAT AAACTAGGTA TTGATGGAAC GTATCTCAAA ATAATAAGAG CTATTTATGA WO 00/09525 PCT/US99/17712 EPI-109 623 42121 CAAACCCACA GCCAATAGCA TACTGAATGG GCAAAAACTG AAAGCGTTCC CTTTAAAAAC 42181 TGGCACAAGA CAAGTATGCC TCTCTCACCA CTCCTGTTCA ACATAGTATT GGAAGTTCTG 42241 GCCAGGGCAA TCAGGCAAGA GAAAGAAATA AAGTGTATTC AAATAGAAGA GAGGAAGTCA 42301 AATTGTGTCT GTTTGCAGAT GACATGATTG TATATTTAGA AAATCCCATT GTCTCAGCCC 42361 AAAATCTCCT TAAACTGATC AGCAACTTCA GCAAAGTCTC AGGTTACAAA ATCAATGTGA 42421 AAAAATCACA AGAATTCCTA TACAGCAATA ATAGACAAAC AGAGAGCCAA ATCATGAGTG 42481 AACTCCCATT CACGATTGCT ACAAAGAGAA TAAAATACCT AGGAATCCAA CTTACAAGGA 42541 ATGTGAAGGA CCTATTCAAG GAGAACTACA AACCACTGCT CAAGGAAATA AGAGAGGACA 42601 CAAATGAATG GAAAAACATT CCATGCTCAT GGGTAGGAAG AATCAATATC ATGAAAATGA 42661 CCATACTGCC CAAGGTAATT TATAGATTCA GTGCTATCCC CATCAAGCTA CTACTGACTT 42721 TTTTCACAGA ATTAGAAAAA AACTACTTTA AATTTCATAT GGAACCAAAA AAGAGCTTGT 42781 ATAGCCAAGA CAATCCTAAG CAAAAAGAAC AAAGCTGGAG GCATCATGCT ACCTGACTTC 42841 AAACTATACT ACAAGGCTAT AGTAACCAAA ACAGCATGGT GCTGGTACAA AAACAGATAT 42901 ATGGACCAAC GGAACAGAAC AGAGGCATCA GAAATAACAC CACACATCTA CAACCATCTG 42961 ATCTTTGACA AAGCTGACAA AAAGAAGCAA TTGGGAAAGG ATTCCCCATT TAATAAATGA 43021 TGTTGGGAAA ACTGGCTAGC CATATGCAGA AAACTGAAAC TGGATCCCTT CCTTACACCT 43081 TATATAAAAA TTAACTCAAG ATGGATTAAA GACTTAAATG GAAGACCTAA AACCATAAAA 43141 ATTCTAGGAG AAAACCTAGG CAATACCATT CAGGACGTAG GTATGGGCAA AGACTTCATG 43201 ACTAAAACAC CAAAAGCAAC AGCAACAAAA GCCAAAATTG ACAAATGGGA TCTAATTAAA 43261 CTAAAGAGCT TCTGCACAGT AGAAAAAAAA AAACTATCAT CAAAGTGAAC AGGAAACCTA 43321 CAGAATGGGA GAAAATTTTT GCAATCTATT CACCTGACAA AGGGCTAATA TCCAAAATCT 43381 ACAAGAAACT TAAACAAATT TACAAGAAAA AACAAACAAC ACCATCAAAA AGTGAGTGAA 43441 GGATATGAAC AGATGCTTCT CAAAAGAAGA AGTTTATGCA GTCAACAAAC ATATGAAAAA 43501 AAGCTCATCA TCACTGGTCA TTAGAGAAAT GCAAATCAAA ACCACAATGA GATGCCATCT 43561 CATGCCAGTT AGAATGGCGA TTATTAAAAA GTCAGGAAAC AACAGATGCT GGAGAGGATG 43621 TGGAGAAATA AGAATGCTTT TTACAGTGTT GGTGGAAGTG TAAATTAGTT CAATCATTGT 43681 GGAAGACAAT GTGGCGATTT CTCAAGGATC TATAACTAGA AAAACCATTT GACCCAGCAA 43741 TCCCATTACT GGGTATATAC CCAAAGGATT ATAAATCATT CTACGATAAA GACACATGCA 43801 CACTTATGTT TATTGAGGCA CTATTCACAA CAGCAAAGAG TTGGAACCAA CCCAAATGCC 43861 CACCAATGAT AAACTGGATA AAGATGATGT GGCACATATA CATCATGGAA TACTATACAG 43921 CCATAAAAAA GGATGAGTTC ATGTCCTTTG CAGGGACATG GATGAAGCTG GAAACCGTCA 43981 TTCTCAGCAA ACTAACACTG GAACAGAAAA CCAAACATTA CCCATTCTCA CTCATAAGTG 44041 GGAGTTGAAC AATGAGAACA CATGGACACA GGGAGGGGAA CATCACACAC TGGGGCATGT 44101 CAGGGGATGT GGGGCTAGGG GAGGAACAGC ATTAGGAGAA ATACCTAATG TAGATGACAG 44161 GTTGATGAAT GCAGCAAACC ACCATGGCAC ATGTATACCT ATGTAACAAA CCTGCACGTT 44221 CTGCTCATGT ATCCCAGAAA TTAAAGTATA ATTTAAAAAA AGTTTAAAAA AAGAAAGTTG 44281 CCTTAGTCAC ATAACTAGTA AGAGACATGG TTGGGAATTT GAACAGAGGC CAATCAGTTC 44341 CAAATCCATG CTCTTGATCA TTAAGCTGAA CTTATGGCAG GAACTTGGAA GACATGGTAA 44401 AATGGGGAAA AACGTGGAGC CAGGGAGACT TGTGAAAGTG CCAGTGCTCC CACTATACCC 44461 TGAAAGAAGT ATCTAGACTT ACTTTTTTCT AAGTCCTCTC CTCTAATTCT CTCAATCTCT 44521 CTCTCTCTTT CTCTAAGAGA TGGGAATGCT GCTCTGTCAC TCAGGCTAGA GTGCAGTGGT 44581 GCGATCATAG CTCATTGCAC TCAAGGAATC CTAGGGTCTA GTGCCCCTTC TCCCTCAGCC 44641 TCCCATGTAG CTAAGACTAC AGGCACATGC CCCAACCCTC GACTAATTTT TTTATTTTTT 44701 ATTTTTGTAG AGACAGGATC TCACTATGTT GCTCAGGCTG TAATTCTGTC TTGAAGCTTG 44761 TCCAATCAGG CTTTCAGCCA CACCAATTCC CTGAGACTGC TCTCACCAAG GTCCTACACT 44821 TCACTAACAC AAACAGCCTA TTCTCCATCC TCATCTTACT TCACCAGGGA GCTCCTGGTT 44881 TTCCTCCTAC TTCACTGGCT ATTTCTTCTG TATCATGTGT TGATTCTCCC TCATCTCCCC 44941 AACCTCCAAA CCCTTGGAGT ACTCCAGAGA TCACCGCTTT GCTCTTCTGT GTCTAACCTC 45001 ACTAACTTGG TGGTCCAATT CACACTCTTG ACTTTGAATA CCATTTAAAT GCGAACGAAT 45061 TCTAAATTCT GTACAACCAG AACCATTCTC CTGTAGCCAA ATGCCTACTC AACATCTCCA 45121 TCCCCAAACA AATTTAGTTG TTCAATAAGC CTCTCATATT TTACATATCC CAAACTGAAC 45181 TTCTGAATTT CTCCTCCAAT CTGTAGGGCT CTTCCCACAG CCTTTCCATC TCAGTGGATT 45241 ATAACTCCAT CCTTCCAGTT ACTCAGACCA AAACTTTTGG AGTTAACTGA GACACCTCTC 45301 TTTTTTTTCA CAAGTCATAT CCAATGTGTC AACAAATTTT GGTAGTGGAA ATATTGCGGG 45361 ATTTTTTAAG AAATCAGAGA GACCGATGGG GTTCAGGAGG ATATTTATTA TTTAGGTGCA 45421 CTGGCCAAGT CAGATTAACA TCCAAAGGAC TGAGCCCTGA ACAAAGAGTT AAGTTACCTT 45481 TTAAGCATTT TGTGGGGTGG GAGAGAGGGG TATCTGTGCA GGGGGAAGCA TACTACAGAA 45541 GTGAGAAATA AAGACAGTTA TTCAATTAAT TGAGACATGC ATTACATCAT TTCTTACTTT 45601 TCAAGAAGAA ACATGTTTTG CGACTTGAGT TTATCTGTCT AGTGACCTTG CAGCTGCACA 45661 GCTAGAGAAA CAGGGTCTTC ACAATGCCTG GGAAAGGAGG AGAGGTAAGT CTCACTAGCC 45721 ACAGAAAAAC AGGCAGTTAA TTTTTAAAGG GCTCCAGCTC TTTCTCTTTC TCAGGGGGAG 45781 TTGGGTTTTG TTACATACAA CTGAGTTTCC GCTTACACAT TATTTAATTT CTTTTAATTC 45841 CTGTTCCAAA AGAAGCCAGA TACAAAAGGT TACATGTTGT CTGATTCCAT TTATATGAAA 45901 CATATAGAAG AGGTAAATCC ATAGAGACAG AAAGTAGATT AGAGGTTCCC AGGGGCTGAG 45961 GAAGAAATGG GGACTAACTG CTTATAGGGT ACAGAGTTTT CTTCTGATAA AAATATTTTG 4A6021 GAACTAGATA GACATTTTGT TAGGCCATTC TTGCATTGTT ATAAAGAATT ACCTGAGACT 46081 TGGTAATTTA TAAAGAAAAG ATGTTTAATT GGCTTACACT TCTGCAAGCT TTACAGGAAG 46141 CATGGTGCCG ATATCTGCTC AGCTTCTGGT AAGGCCTCAG GAAGCTTACA ATCATGGCAG 46201 AAGGTGAAAG GGGAGCAGGC ATATCACATA GCAAAAGCAG GAGCAAGAGA GGGATGTGGG 46261 GAGGTGACAG TCACTTTTAA ACAGCCAGAT CTTGTGAGAA CTCATTCACT ATCATGAAGA 46321 CAGTACCAAG AGGATGGTAC TAAATCATTC ATGAGAAACC CCACCCTCAT GATCAAATCA 46381 CCTCCCACCA GGCCCCACCT CCAACACTGG GGATTACAAT TTGACATGAG ATTTGAGTGA 46441 GAACACGGAT CCAAACCATA TCAGAGATGG TGGTTATACA ATGCGATAAA CGTCACTGGA 46501 TTGTACACTT TAAGATGGTT GTTTTATGTT GTGTGAACTT CACCTCAATA AAAAAAAATA 46561 TTTAATGTAC ATTCAGCCAA AAGAAGATTT GGAATAGGAA AGGTCATGGA GATATATTAA WO 00/09525 PCT/US99/17712 EPI-109 624 46621 CAGCCATTTG ATGGGTGGTA AGGAAAAGAG TGGTTATTAG ACTGTTTTGT GGCCCTCAAA 46681 AGGTAGAACT AGATCGAGTT GGTGAGCATT ATAAAACCAT CACAAAACCC TGGAGAGAGG 46741 ACCCAGTGCT GAAGAACCGT TTGCCTGCCA TGAGACATGA GGGAAGTACC AGTGAATGCC 46801 ATTGAAAGCA GCATCCCTGG GTCCAAGGGA TGGTCAAAGG ACCACTACCC AACCCTTCCC 46861 TAGCCTACGC CTCCATTACA GATGACCGCA AGATTTATTT GCTCATTGCT GCCAACCAAG 46921 GCTGCACTCA CTGCAGTTGC TATCAGTTTA TCATGGGTAA AAGGAATGTG CAGTAGAGAA 46981 CTAACTAACT GCCCACCTAC CTCCACAATC CTATCAGGAC AAATCACCAT GGCTCACATT 47041 TCCTTACATT TGGCATGTAA GCCCCTCTTA CTGTCTGTCA TCTATCTCCT ACACAGTTCA 47101 CCTAAACTGT TCTCTCCTGA CCCAACCTTG ATTTTCATCC CAAATGCTTC CTTGCCATCT 47161 CTGGGATTCC TGTCTTCACC ATCACCAAAC TCCCCTCAAT CTTCCAGTTT CCTGTTCAAA 47221 CTTTTCTCCT ACCTCCTTGC TTTGTCATTA GCCCGACTGC CTCCCTAGGA CATCACTTCC 47281 CCTGCAGATC TCTCAAGATG ACAATATTTA TTCTCCACAC AGCACATACT TCAGGGTTGG 47341 AAGGCAGGGG CAATCTTCTC CTTTATAATG AGTGCCTCTT ATATATGTTT ATTCATCTGC 47401 CCTCTTGTAA AACACACACA CACACACACA CAAAGAAGAA ATAAAATAAC TCTGCTTCTT 47461 TGAAGCTTGT GACACTGAGA TAAACCATCT CACTGTCCTC ATTGTAGTGA CCTCTCAACT 47521 CCTCATGCAA GATTGGCTTT GGCACCTAGT TCCTGATCTT CCTTTCCCTG TAAGCACTTC 47581 TCATAGTCTT ACGGGACTTC ACCATCCATG GCACAACCAA TACCACAGCC CAGATCCTCA 47641 GCTCTCCAAT GACATTTTCC TCCACTAGAC TTGAGCTACC TCCTTCCCTA GGCACAGCCT 47701 CAACCTCGAC AACACCTAAG ACTGTACCGT CTCTAAAGTC ACATGTTCAA ACACTTCACT 47761 CTTTAACCAC TGTCTCCTAT TCTTGCAAGT GTATTGCTCA AGTATCTCAT TGCAATGCTT 47821 TTTACTTCTA CCTCATTGAA CCTCCAGGCC ATTAAACATT TCCTTATTTC TAACCATCAG 47881 GTTTCTCCTT ACTTGTTTGT TTGTTTATTT GTTTCTTTTT TTTTTTTTTT TTTGAGACAG 47941 GGTCTCACTC TGTTGCCCAG GCTGGAGTGC AGTGGTATGA TCTCGGCTCA CTGCAGCCTC 48001 CATCTCCCTG GTTCAAGTGA TTCTCATGTC TCAGCCTCCC GAGTAGCTGG GACTACAGGT 48061 GCATGCCACT ACGCCTGGCT AAGATTTTGT ATTTTTATTA GAGAAGGGGT TTTGCCATGT 48121 TGGCCAAGCT GGTCTCGAAC TCCTAACCTC AGGTGATCCA CCTGCCTCAG CCTCCCAAAG 48181 TGCTGAGATT ATAGGCATGA GCCACTATGC CCCACCTGGT TTCTCCTTAT TTATTTCAAG 48241 TCTATGCTGC ACTATTAAAA CTGCCTTGAC AAAAATTATA ATAGTGAGAA AATTATGACA 48301 GTGAAAGAGA TCTGAAATAA TCAACCCCCA TCTTGCCTTT ACCTTCCAGA CTGCCCTTAA 48361 TAATTCCTGA GCTTGGGCCA AGCTATCTTT GGCAGAAATT TAGTTTATAG TTTAAATGAT 48421 AATAGCCCTT CTCCAAAACT AAACTGCCTT TGTAAAACTA ATAAAAGACC ACCAATGAAA 48481 GGTTAGGAGG ATGAGAGGAG CCTGAATTCT GCTAAGGTGT AGATGTAAAC AATTACCAAC 48541 TGTTATTCCG GAGGTCACAA GATTTGCAAC ATCGCCAATT ACTCCTGCAG ATAACAGCAC 48601 TATCATAGAA TCTGATTGGC CTTTTGAGAT GTCTTTTCAG ATTCTTACAT TTCAACTGGT 48661 GGCTCTACCT GGACCCATCA ACAAGTCCTG TGGCTCCACC CAGAAGCAGA CTTAACATGC 48721 ACAAGGACCA TTTTCCACAC CGCTATGATT GCATCCCAAC CAATCAGCAG CAACCATTCC 48781 TCTGCCTGCC AAATTATCCT TGAAAAATCT TAGCCTTAGA ATTTTGGGGG AGGCTGATTT 48841 CAGTAATAAC AAAACCCCGG TCTCCCATTT GGCTGGCTCT GCATGAATTA AATTCTTTCT 48901 CTATTGCAGT TCCCATCTTG ATAAATCACC TTTATCTGGG CAGCAAACAA AAGGAACCCA 48961 TTGGACAGTT ACACTGTTGG CAGATATATC TTGCTTCCAA AATTGGATTT TTGTTTAATG 49021 AATTTATTCT GTTTTCTTGA TATTTACAAC TGTGAATGTT GTGTCTGAAT TCTCTTTATT 49081 TCTTGTTGAA AAGAACTATA TTGCTACAGC CAGTACATAC AGATGGATAG CTAATTACTC 49141 AACACGGGGG GATGTGACCA TCACCGCACT GTGCAAATGA ATGTTACCCA TTGTCCACTT 49201 TTCCCAAACT ACATAGTGTT ATATGGTATA TGACCCAATC AACGGTGGCA AAGCTCCAGA 49261 AATACCACAT AGACATCAGG GACACTTTAA ACTAATCAGC CTATAGTCCT TTTTCAGTAA 49321 TTTCCAAACC TGGTTGTGCA TCCAAATCAC TTGGTAACAT TAAAAAAACA AAAAAATATA 49381 CACGCAACAT TCGCTCCCAA TCCTACTGAA TCAGAATATT TTGGGTTGCT TCAGGAACAT 49441 TCAGGAGTTT TTCAGGGTCC AAGGTTTATA TAATTTGAGG TCTCTCTTTG AGAAAAGGAA 49501 CGTAAAAGCG TCTTGCTTTT ATAGATCTTA CAAAGATGTA TTACCATGTA AACACATTCC 49561 TAGGACCCAG GCCCTTGTAA TTTAAAGGTT TATCTAAGTA ATGGGCCCTG AAGCTTAATT 49621 TTCATTATCT TCAGGGCAAA TTACCTGTGG GTTAGGGTTT AGGAATATAT CTCTCTGTGT 49681 ATGTGTGTGC ACATTAGCAT GTACGCTTGT GTGGATTTTT TTTTTTTTTT TTTTTTTTTC 49741 TGAGACAGAG TCTCGCTCTG TCGCCAGGCT GGAGTGCAGT GGCGTGATCT CTGCTCACTG 49801 CAAACTCCGC CTCCCAGGCT CAAGCGATTC TTCTGCCTCA GCCTCTTGAG TAGCTGGGAC 49861 TATAGGCACG CACCACTATG CCCAGCTAAT TTTTGTATTT TTAGTAGAGT TGGGGTTTCG 49921 CCATGTTGGC CAGGATGGTC TTGATCTCTT GACCTCGTGA TCCACCCGCC TCCACCTCCC 49981 AAAGTGCTGG GATTACAGGC GTGAGTCACC ATGCCCAGCA CTTGTGTGGA TGTTTTAAGC 50041 TCCCAGGTGA GTGAATACAA AACTAGATCT TTCCCTTCTG TAGCATCTGT ACTGTTTACT 50101 CTATGCATCT CAATATTTTT TCTTTTAGTA TCTTTCCTTT TTCTCTCTTA TTACTTCCTC 50161 TTGTGCTATT TTTACACCTC CTTTTTTAAA AAATTTTTTC CCTTTTATTT CTATTGACCT 50221 TTAGCCCTCA CAATGATTCC TACAAGCCCC ATTTCTGTAA ATGGGGATTG AAATAATTGC 50281 TGGACTTTTG AGAGATAGAT ATATTAAATT GCAAACTGGC AGTAGTGGGG GCAGTTGATA 50341 CATAACTAGG TTTTAAAGTC TAGCCTTCTG AGACCACTCA TTCCATTTGT GAAAAGTGAT 50401 TCTACTTCTT ATTATGAGCC AAAATATGCA TTCATTCACC CATGCATTGA TTTATTCATT 50461 CAATAAATAT TTGTTGGATG TCCACTCTGT ATCAGGAATG TGCTAGGTTC TGGGAATACA 50521 GCAATGAACA AGGTAATTTT TCCCTACCCC TAAGGAACTT AGAGTTTAGT GGGGAAGACA 50581 GACATTAAAC AAACAATTGT GCAAGTAATA ATCTATAATT ATTTATTACA ATTAAAGGAA 50641 GGAAGAGACA TATGGATTAT GAGGGCATTA AAGAGGAGAC CTAGTGTAAG TAGCCAGTTC 50701 TCGTGAAGGG ACATGTATTA GTTGGAGTTC TCCAGAGAAA CAGAACCAAT GGTGTGTGTG 50761 TGTGTGTGTG CGTGTGTGCG TGTGTGTGTT GGGGTGTGGG GGTGTGGTAT TTTTTATAGA 50821 AATTGTCTCA CACAATTATG GAAGCTGAGA AGTCCCATGG CCTGCTGTCT ACGAGCTGAG 50881 AACCAGGAAA GCCAGTGGAA TACTTCAAAG TCCAAAGGCC CTGGAACCAA GAGTGCCAGT 50941 GTTGGAAGGC AGGAGAAGAT GGGTGTCCCA GCTTAAAAAG ACAGTGAATT CACTCTTTTT 51001 GCTCTACATA GGGCCTCAAT GGGTTGGATC ATGGCCACCC ACATTGGTGA AGGCAATCCT 51061 CTTAGTCTAC CAATTAAATA CTAATCTCTT TGGAAATACT CTCACAGACA CACTGAGAAA WO 00/09525 PCT/US99/17712 EPI-109 625 51121 TAATGTTTTA TCAGGGTGAT AGAAATCTTC TGGAGTTAAA CAAT-GTGAT AGCTGTACAA 51181 TCACATACAT TTTTAAAGGG TGCGTTTTAT GGAAAGTGAG TTTTATCTAA ATAAAATTTC 51241 TAAGAAAGAG ACTTAACACA GAGATAAACA TAAGCACATT TATTGTCAAC CTTTATAGTG 51301 TTATGTCAAA TAGGTCTGAC ATAAGCTTAA ATAAATATAT ACTTTAAAAA TTATAAAATA 51361 TTTTAAGTTA TAATTTAAAA TTCTCAATAA AACTCAAACA CAAACCACAC TGGTATTTCA 51421 CACAGCTAAT TTCTAATGCA GTTTACATAA ATATTTACAA CACTTAAACA ATTTCAAAGA 51481 AAATAACACT GTATTCCATA CATAGCCTGA TCACAGTAGT TGTTCTCTCT TATTTCCCAG 51541 AGTTTTTCTG CCCCTTTAAA AGAACCTCTC CTGTTCTGAT CCTTATCACA TCTCTGTTTT 51601 GACTGTTGGC TTTGTTGTTG CCAGTGTTCA GCCAGAACTT CTCTGAAACT TTTTTTTCAA 51661 CACATGCTAA GTTAATGGAA GTGTAGGAGA GTTTTGATTC TCACACTCCT CAAGGCTAGA 51721 GCAGCTTTGG CAATTACTGA CTGAGAATTT TTCATTGCCA GTGATCAACT GAAAACTGGA 51781 GATTCCTTTG GAATTGTTAA ATCTGCTTAT AAATAAACAT AAATGCTTGC TCACACAGGC 51841 ATTCCTCTCT TCCAGAGCAC CCTAACATAC AGAAGAAAAC AAATAGGGAA TAACTATTAG 51901 ACATCTTCAT TCGTTAAAAA TCTACCAGAT GACTCTTTTA CATGGTGAGT TTCTATTGTG 51961 AATTTAAAAT CTTCCATAAT ATACAAGAAT TATGTTTACA TATCATATCT GACAAACATC 52021 TTTGTAGGAA TGCAAAGCAC ATCCATCTTT CTGTATTCTT TTCCAACAAA GACATTCATA 52081 AAATTATACC TTTGTGTGTT TGCATTTATG CTTTTATTAG TTCAAAACGT TTGGCCTCAT 52141 GGAAGTTTTT CATCGTGGAA ACCACATATT TCTGAAAAAA TATCTGACAA TATACAAACC 52201 TTCCATTCAG TTTTTACTCT CCAATTCTAC CATGTTTTCA AAAAACAACT GTAGTAAAAA 52261 CACTCAGAAC TTTATTCTGG TTAACATCAT GCCTTGCTAG GGGACAATAG TTTCCCTTTT 52321 TGAAATAAAT TTAAAACAGA TGTAACATAA TTTGTTAATA AACAATGAGG GGTAATCTA 52381 GAATAAGTAA CTTTTACCAT ATCATAGTTG ACAGCATTTA CAAGTTTTTT AAGTCCCTAC 52441 CACACTTGTA TTGAATGAAG AAGTATGGAA GATTATAATA TATTCAATGC AAGTAAAAAT 52501 ATCACAATCC TTAAGAACTC TTTAAGAAGC ACTGAATCCC ATAGGGATGA AAGTGATTAA 52561 ATTGTGCATA GTAACCCTCG CACAGAGCAT TCAGTAGCAT TTGCACCATT AACAACCCTC 52621 CATGCATTTG CCTGTGGCCA TTCAACATCT GTCATTTTTT TAAGTTATAA TATTTTTAGT 52681 CATTTTTTTC CTCTAAACTC TGGATAATTA TTATTCATTC TTATGACAGC AACTGTGTAA 52741 TCAGCTGTCG AAACACTGTG AAGGGCAAAA GAAAGAAAGC CACAAAATAT TGTGTTTCTG 52801 TGCCAAGATT TTACAGCGAG CAAGGGAGAG TTAGAAAAGG AATTCTGAGA TTTCAGAGTC 52861 TTGGTCTCTT CACCTTTGCT TGGAAGGAAA TATCCTTTCC CTTCATTAGC CAACACTTTC 52921 TTGATCCTGA GAGTAGGAAA GGGAACACTG AGTCTTTTCA GTTGAAGGCC GTCCTTGCCT 52981 GCTGGACTTT GATCTATTGA AGTGGTGAT GGTGTTGCCG TTTCAGCCAT AAAGGCATCT 53041 GGCATAGTAG GCAAGAAGGG CCAGAGACCC GAGGAGAGTT ATCTGTCTCT GTTAACTTCA 53101 GTGTATCCCT CTAGTTCCCC AGATGCACCT GTTTCTGTAA ATATAAACAT GCATGTCATC 53161 AGAACACTTA ATATTCTGCA TACTGATCAT GACAACAAAA TGTACCTTCT AACACAGACA 53221 CTCTCACTAG GATACACCAT GTAGGAACAT CGAATTCTAT TCAGTTAGGA CAGTGATGAT 53281 GTCTACATAT TATACCTCTG TCAAAACCTA CAGAATATAC AACACAGCAC AGAGTGAATT 53341 CTAATGTAGC CTGTGGACAT TAATGAATAA TAATGTATCA ATATTGGCCC ATCAGTTGTA 53401 ACACTAATAT AAGATGTTAA TAACAGGGGG AATTGAAGGG GTGGTGGGGA GATATGTTGG 53461 AACTCTTTGT GCTTTCTGCT CAATTTTTCT GTAAACTTAA AACCGCACAC ACAAAAAAAG 53521 TTATTTTAAT TTTTTAAAAA GTATTCAGAG GGACTTGACC TTTCCAAATT CTCTCAAAGC 53581 AGGTCGGAGT AGTTAAGAAC ACAAATTTTA GAACCAGACT GCCAGAGTTT GAATCCTGGC 53641 TACACCACTT ACTAGCTTTG AGATTTCAGA CAATTTACTT AACTTCTCTG TCTCATTTTC 53701 TTCATCTTG TGATAAGAAA TAAAGTAACA GGCCAGGCCC AGTGGCTCAC GCCTGTAATC 53761 CCAGCACTTT GAGAGGCCAA GGCGGGTGGA TCAGGAGTTC AAGATCAGCC TGGCCAACAT 53821 GACGAAAAAA TACAAAATCT CTACTAAAAA TACAAAAATT AGCTGGGTGT GGTGGCAGGC 53881 ACCTGTAATC CCAGCTACTC AGGAGGCTGA GGCAGGAGAA TTGCTTGAAC GCAGGAGGTG 53941 GAGGTTGCAG TGAGCCAAGA TCATGCCACT GCACTCCAGT CTAGGCAACA GAATGAGACT 54001 CCATCTCAAA ATTAAAAAAA AAAAAAGTAA AAAGAAAAGA TAAGAAATAT AGTACCAGCC 54061 CCTATCTCAG AGTTCCTAGC TTAGAAAAAT TCCCAGAATA TAATAAGTGC AATGTAAGGG 54121 TCAGCTATCT TCATTATTAT TATCTATCAT AAATGAAATT ACACAATAAA GCTAGATCCG 54181 TTTCTTTCCT CTCCTTCTAC AAAAAATAAA GCAACTTTCC AGAACAATAC CCAGGTGATG 54241 ATTTCTCCCC TGCTCCCTCC CTAAGATATT GGCAAGTTTG GAGGGTTCAA GGAGAAACAG 54301 AGCATGTAGA GAAGATACCT CTCTCATAAC CATTTGTGAT TTACAAGTCT TACCTGATTC 54361 TTTTGAACTT AAAGGATGTA AGAAGGCTTT TGGTAGCTTC CATCTGATTC AAGGCTTTGG 54421 CAGCTGCTGT GGAATACATG AGAACACTAG GTAAAGCACT GTCTTCCAAC ATGAAGAGAG 54481 AAAAATATGT GGAATGTTCA ATGGCATGCT TTGTATAAGA ATGCAACTTA CCTGGCAGGA 54541 ACAAATTTCT TTGCTGCAAA AGAAAAGACA AACAACCATT AATTCAGACT AAATGACTTT 54601 TAAGGATATA TTAAATCCAG ATACAATATG ACTTAATTCA TCAAGTGTTG CAAACTCGAT 54661 GCTTCAGGGC CTCTGTAATA ATCAGAGCAC AAGCATGGCT CTGTGGCATC TAGGGTAAAA 54721 TGCACAGTGC ACAGCCATCC AAAGGGCATA GCAGCTTCCT AATGCCAGCA AATAGCTACG 54781 GGGTCATCTT GCCCAATTCA GCTCCCAATT TTTCATGAGA AGTCCAAAGT CTTAATTTAA 54841 ATGTGAGATT TCCTATTTTG TAAACGTCAG AACTTAACTC AAAAATGTTT TAAGTACTCT 54901 TAAACATGTA AGCCAAACAA ACCATGAGTG TAGTCAGATG TGCTTCCATA TTCCTTATGA 54961 GAGACTCTCA AATTTAAGCC TGTACTCCAA ATAAATCTCC TTAGGAAGAA TTTTATCCAT 55021 TTTCCTTAGA GTGCTCATCA TGGCAGTTCC ATTGCACAAT TCCGGGAGGC ATCATATAAT 55081 TCAACATGAA TAGCACCCCC TGGAGTTGTA CAATATTAGG CACGACTAAC ATTTTTATTT 55141 CCTGAAACAC TTCCCACACT GAGTTGTACT ACTAACTCTT TTCTTAATAC TTCTGCTTAA 55201 TTATACTGCA TTTTATCCAG ATTCTAATTA TTGTTTAAAT CAGTAAGCAA GACCATGACT 55261 TATCAATGAG AAAGAAATGT ATTTTCAAAA ACATTTTTGA AGTACATTCA TAAACTTCCT 55321 CACCTTTCCG TAAGCATTTC CGAAGCCAGA GGAGAAATGG TGCTAATGTC AGGAGGGAGA 55381 GTCCAGCAGC AGAAAGTCCA GCTACCAAGG GAATGTTGGA CTCAGTGGGA GCTAAGGAAG 55441 TAAGAGACGA AGAAAGGTCA TGAGGAAGAA TTGATGTTAA ACTCTCTCCG TCCTCTCCCT 55501 TTGGCCTTTT TTCTGTACAT TCATTACTAG GAGCAGAAGA GCTATCTAGT TTAATACAAG 55561 AAGCAGAGAT GTGGCATTAC AGGCCTTTGA GATCTGCTCC AAGCCACCTT TGAAGCTATT WO 00/09525 PCT/US99/17712 EPI-109 626 55621 TCCACCATTG GCAGGCAGAA CTCTAACTTG CCAAGCTCGT TCACAATACC ACACCACACC 55681 TTGGTTAATA AACACTGCAC TTGCTTGCTC TCTTGCTCTC ACTCCCTCTT GTTTTCCATT 55741 TCCCCTTTCT CCTCTCCTCT CTCTGTCTCC TTTTTCCAGT TGTCAGAATT CTACCCTTTC 55801 CATCAACATG CAACTTCTGT TTTTTCTCTA TCCCCATACA ACTTAATATT CACAACTTGT 55861 CAACCTGGGC GAACTTTCTG GTTTGGATAT AATGAATAGT TGATTACTGT AACAAGATAG 55921 CTCCCCCTTT TTCTTTTTAA TCACCAGACA ACCACCATCA ATCAATGCAT CACCTTCACA 55981 GGTAGGTAGC AGGCCAGACC AGTGTCCTGT GGCTCCACAT GTCCGAGCTG CAGAGCCATT 56041 GAGCGTCCAT CCTTCAGGAC AGGCGAACTT GCACACAGTG CCAAACACGG GCTCCCCACT 56101 GCAGCTCATG TTGATCTTTC CCGGAACTGC CAGGCTTGAA CATTTTACCA CTGCAAATGT 56161 TAGGTACACA GGCAGAGTTT CAGAAAAATC TACTGGAAAA CTTCCAAAAC TTGCTTAAAA 56221 GTCAACAATG AATGTAAAGT GTAAGCGCTA CTTAGTTTTC AGCATGTAGG AAATTAGGAC 56281 CAAACCCCTT TGGGGCAATC TAGGTTCAGA AACTTTATGA AGTATTTGAC CTGTACCCTA 56341 AAAAAGTCTG CACTCAATTC TACCTTGGCA GGAAGGAACC TCTTCTGTCC ATTGTCCCTG 56401 AGATGTGCAC TCAAGTTGAG TTGATCCATG TAATTCAAAT CCCTCCTCAC AGCTGAAGGC 56461 ACAAGAGGAC TTGTAGGTGA ATTCTCCAAT AGGGGAATGA GCACACCTCA CCAAACCCTT 56521 CGGGGGCTGG TGGACAGCAT CGCATCTCAC AGCTGGAACA CACGAGAGAG CACTTTAGAA 56581 GTTTGTTTGC ATCTCCAGCA ATACGTTTCC CAAGGTAACC AAGTTCCCAA GCTCTTCAAT 56641 AGTTCTTTTT ATCTTAAAAT AAAATAAAAA CAAAGACTGT ACCTTCACAT GTGGGCTTCT 56701 CGTTGTCCCA CTCCCCTGTG GGGCCACATT GGAGCCTTTT GGATCCCTTC AACACAAAAC 56761 CCTGCTCACA GGAGAACTCA CAGCTGGACC CATAACGGAA ACTGCCAGAA GCACTAGGAA 56821 GACAATTCAT GTAGCCTCGC TCGGGGTTGG ACAAGGCTGT GCACTGGAAA GCTGAGACAT 56881 CAAAATGATG GTCAGAAAAT ATTGCAGTGG AACTAGAGAG TACTTGGCGT TTGTTGAGTG 56941 AACCCAGTTC ATTCAAGCAA CACTTGGAGA ACTGAAGATT CTTTATAATT CCCTGGACAA 57001 ATGGGAAGAT GGCTGTGTTT TCTTTGAATT TCAGCCCCCT CACTGATCAT GGCACTAATT 57061 AAAAGACTAA TTAATCAGAA CATTAGTTCC TGAGCACTGT TCTTCTAACA CACAAAATAA 57121 ATTATGGTCC AAGGAAAGAT TTCACGCAGT CTGAGGACAA CATATGGGTC ATGGATGTTT 57181 ATAGATGGTG CCAAAAAGAA AGAAAAGAAA GCACCCCTAT AAAATTTGTC TGTTTTGCAG 57241 TTTGGTTTTT GTGTTATGTT TTGCTACTGG AAATCATTCT GTGCTGGCTT TGGCTAGGAC 57301 AAGGCCAGTG CCTGATAGTA AAAACTGCTT GTTTTCAATA TCCTTGCTCT CACTTTAAAG 57361 TGAATTAAAA TTTACTGCTT ATATATGCAT CAATACTATC TCTGTAGCTG ACACCATGCT 57421 TGAAACAGTC TCATCACTGC TAATTATGAG CCATTTCAGA AGACAGGTGT GATGAGAGTT 57481 TTACATTCAA ATCATGTTCT CATTATTCTG CTTTCCGAAT TTTCTAATAT GATTCCTTTA 57541 GATTAAGAAT TCTGTCTATT CCATGCTAAT GTCTACAAAG TTTTATCAGC ACATCACAGT 57601 TAAAAAAAAA CAGCAAAGAA TTCATTCTTA ACACATATGA TCCTTTCCCT GGCCAAACAT 57661 TAGTTCTTTT AAATGAATCT CAAAGATACG AGGGTTGCTC ATCAAATCTG ATTTCTATAG 57721 TTAAAGTGGG TATTGGTTTT TTTTTTCACT GTCCAACTTT GAAGATGGTT GTTCTTTAAG 57781 AAAGTATAAA TCGAAGGATC TCAAGCTTAC CTTCACAAAC TGGGATTTGC TGTGTCCACT 57841 GCCCTTGAGT GGTGCATTCA ACCTGGGCTG GTCCCTGCAA CATGAAGCCT TCCTCACAGG 57901 TGAAGTTGCA GGATGATTTG AAGGTGAACT CTCCAGCAGG GGAATGGCTG CACCTCACAG 57961 AGCCATTCTG AGGCTGGCGG ACGGCCCTGC ATGTCACAGC TGTAACAAAT ATACGCATTG 58021 ATATTAGCAC GGCCTAGAAT TAGCTTGCCC ATTTCCAGTA TGGGTTGAGA GAAAGAATGT 58081 TCACAGTAAG TCTCCATGTG GAACAACTCT ACCTTTACAC GTTGGCTTCT CGTTGTCCCA 58141 ATTCCCAGAT GAGGTACACT GAAGGCTCTG GGCTCCCATT AGTTCAAATC CTTCTTCACA 58201 GTCAAATGTA CAGGTTGTGT TCCATGGGAA GCTTCCAGGG TTTTGGAAAC ATTCCACGAA 58261 CCCATTGGCT GGATTTGTCA CAGCATCACA CTCAACCACT GAGGATTTTA AAGAGCACCA 58321 TGAATTTTAC AGAAGAATGA TCTTTTCACT TCCTATTGAG CTGGGTGCCT AACAGAGTGA 58381 GGAAGCTGCC TTCAAAGGGT AGATCCCAAA GTCCTATGTC AATTCTTAGG GACATGCACA 58441 GCCAGAATAA AAGCTTTTAT TCTTTTTCAT GGATATTCTA TCTTTTCTGA TTTCCACTTT 58501 GCCTATGCTG AGTGGTCTCT AATCTATGTT ATCATTTACG TGAGGTAAAA ATTTAAAAAA 58561 AATAGATTCC AGATTAGGAG TTATGACTAG TACTGACATA CGTAGGCTAT TCATTTATTT 58621 TAGCCCATCA GAGCCTGAAG AACTGATTTT TCTTTTTTTG GCCTCTGGTT CAGAAAGATA 58681 AAATTAAGAG AGAAAAAGAG ATACTAAGAC TGCTTGACTA TCATGGTCTT AAGTTAGTCC 58741 CATGGCTTGG AAAAGTTAAA CAGGGAAACA AGATGAGAAA TCCATTGAGA TTTCTAGAGC 58801 TTTATTGTTT TATGGTCTCC CTTACAAATC ACCAGAGCCT CAGAAACACC CATTTCAAGC 58861 ATAGAATAAA AAAACCTCTC TCAACCCAAG CAGGTACTGG GTTGGCAATA TACATTGGCT 58921 GAGAGAACAA ATTGTATTAA AAACAAAAAC AAAAAAAAAA CTTTCCCTGA AGTTTTGAAA 58981 ATGTAAGTTG AATCAAAAAA CAGAAGCAAT GAGGGATGAG TTACAGAACG TTCTGTGCAT 59041 TCTCAGAGGG ATTTACCATT GCAGGCTGGA ATAGGAGCAC TCCATTCTCC ACAGGACATA 59101 CACTGCATGG TCTCCATGCT GCTTGGCAGG TAACCCCTAT CACAGCTGAT AGAGCAGGAA 59161 GAATTGTAGC TGAAGTTTCC CAGTGGGTGA CTGCAAACCA GGCTTCCATG CTCAGGGGAT 59221 TCCAGGGCTG TACAGTTCAC AACTGAAAAA GAAACCCAAA TCAGTTCTGC TCATCTCTCA 59281 CCTTTAACAG ATAAGAACAC TGGAAACTAG AACTACAGTT TGGTTTTTTT TTTTTTTAGT 59341 TTAAAAATTT ATAAAATTTC TAATGGAATT TGTAAAATTG ACTGTAATTC TACCCCTTTT 59401 CTTTTATTCA AGAAAATGCT GATCCATAAC AACAACAACA AAAAAGCAGT GATGACAACC 59461 ATAAAAAAGA AATATTGAGT GATATGGGGA GAGTAGTGTA ATTGTGTTTA CCTCAAAACT 59521 GTTCAAATTA TATGAACAAA CACAGCAAAC TTAGGTACCA CAACAATTT CTTGTTACTT 59581 TTCTCACAAC TGCTAAAAAT ACTACAGTAA GCTTCCAACC AGGATGAGAA CCATTCACAA 59641 AGCTATATTT CAAATTTAAG TACTAGAATA CATTACAAAT TTTAAAACCC TAATGCTGCA 59701 CTGTCTACTA TAGTAGCCAC TATCTGTGTG GCTACTCAAA TTTAAACTTG AATTCGTTGA 59761 AATCAAATAA CATTTAAAAT TCAGTTCCTC AGTGTCACCA GCCACATTTC AAGTACTCAA 59821 TAACCACATG TGGCTCATAG GTACACACTG GAAAACACAG CTATGGAACA TTTCCATTAT 59881 CACAAAAGCT CTACTGCACA ACGCTGTGCT AAGGAATCTT GGAGAGAAGC TCATCTAACT 59941 CTCTTAATGT ACAAATTTAG GAACTGAGAC CTCATTTCAT TCAAGTGACT TGCTCCATGC 60001 TACACGGCTA GTCATTACAG AGCCAGAGGC CAGAGCATGA ACCAAGATAC CCTGGACTCT 60061 GTAACTCACT CATTTCTACT GCAACGTCTT GTTACCACCTT AGATGAGGTG AGTACATGTT WO 00/09525 PCTIUS99/17712 EPI-109 627 60121 CCTCGCAGGG ACACAGAATT ACAGTTTATT GAATGTGTCC TTGTGCCAG GCACCATGTA 60181 ACCATGAGCC TATGAAGTTC ACACTATTAT TATCCTCATT TTACAATGAG AAAACTGACA 60241 TAGAGAGTTA AACTATCTC TCAAGGTGCC AAAATAAATA ACTGTGAAT CTAGGACTCA 60301 AACCCAGCAG GGTCTGACTT CATAGTCTCA GCTCACGATC ACCATATGAC ACCATCTGCA 60361 CCAGGGAAGG GAAGGCATGC AGACCTGACT CTAATGCCAG CTAGGACGTG AGATGGTGCT 60421 ACCATCTCAA GTGAAGAAAG AGGCAAGAAC CAGACTTACT TTGCTCACAC TTGAGTCCAC 60481 TGAAGCCAGG GTCACACTTG CAAGTGTAAT TATTGATGGT CTCTACACAT TCACCGTGGC 60541 CACTGCAGGA TGTATTGGTA CAGGCAGCTA CGGAAAATAC AAAGCATGAT GAGGAGGACT 60601 ATTACTGTGC TTATACTGAG TGCCTTTGAT TTTAGAATCA ACAGTGTGCA ACAGAGACAT 60661 CAGCAGTCCT ACAGAGTGCC ATAGACTTTA ACTGAAGTGT TTTACAAAGT TCCAAATCTG 60721 AGTTTCAGGC CCACCTATCC TAAACCTTGA TGCTAATGTA TAGCTGTGGC TGGCACCTAC 60781 CGTAGAAAAT TTACTTCTTC ACAAACTCTG AAGACAGTTC CCCTACCACA AATAAACAAG 60841 TAATTAAAAT ATGTATTSTG TGTGTGCATT TTTATATGTA AAGAACTACA TATTTGCCTA 60901 CAGTATTTAT ATATATTTTA TATATATACA TACACACATA TATGTGTGTA TATGTGTGTA 60961 TGTATATATA TAAAATGTAT ATAAATGCTG TAGGCTATAT ATATATACAC ACACACATAT 61021 ATGTGTGTGT GTATATATGT GTGTGTGTGT ATATATATAC ATATCCACAT ATTCTTGCCC 61081 ACATTCACAC AAAACAGCAA AAGAGAGAAA CTTTAGCAGT TAAACAGAAT CTTTTGGAAC 61141 ATAAAATGAC CACAATAGAG AGCAGTTTTT GCATGCTGTA AATTTGCCAA GATGCCCACA 61201 CACTGAAACT ACCTCCCACT GCTGCCGCAA ACTCCCTACC TGTGTAGCAT AGGGCAAGCT 61261 TCTTCTTGCT GCACCTCTCA TCATTCCACA TGCCCACATC TTTTTCTCTC TTGATGTAGA 61321 TCTCCACGCA GTCCTCATCT TTTTGCCTAT TGTTGGGTTC ACCTGGAGCC CAGTTCTTGG 61381 CTTCTTCTGT CAGAGGTTTC TGGGTTCCTA CCCAGACCCA CACATTGTTG ACTTTTCTGA 61441 TTCCAATCCA GTAATAACTT GGTGAATAGC TCAATATGGA GTTTAGGTAC TCAATCTCTT 61501 CTTTGTTTTG AATTGCAACC AGGTGTGTGT ACCTTTGCTG ACAATAAGCA CTGGCCTCAT 61561 CATAAGTCAT AGCTTCCGTG GAGGTGTTGT AAGACCAGGC TCCACTCTCT TTAATGAGAA 61621 GCACTAGTGG GAGAAAAAGA AAAGAAATGG TAGAGTTTGG TACTGTTGTG GTTTAACTCT 61681 GACAACTGTG CTTTTTATTG TCTTATTTTT GGCAATGTTT GTGACATGGC CCAGACTTTT 61741 CTCATCTTTT CAAAAGTAAG AAGTACGTAT GAAGAAACAG CGACTTATTG TTTATCTCTT 61801 TTGTGACTGC CACCCACTAG GTACCTTATC CACACTCACT CACAACATTA TAGTATACCC 61861 ATTTTGTAGT AGAATAATAA TCAGAATAAC TAAGCTTTAT TGAGCACTTA GTATGCACCA 61921 AGAAGCACTG TATGAGGTAC TTTCCATGAA CCATGCTATT GAATCCTCAC AATGCATCTG 61981 GGAAATAGGT CATTATGATC CACACTTTAC ACTTAAGGAA AGGGAGACAC CAAGAGGTAA 62041 AGTAAATGAC CCCAAGCCCA GGGAAGAACA CATTGCAGGT AGAGGTCAAG GATGCTGCCA 62101 GATATCCTGT GCAGGACAGC CCCAGACAAG CAAGGATATT TCAGTCTGAA ATATCTATAG 62161 TGCGAGAATG AGAAATCTTG GTCTAATGGC ACTGACTTAC CCAAAGTGAG AGCTGAGAGA 62221 AACTGTGAAG CAATCATGAC TTCAAGAGTT CTTTTCACCC AAAGGTTTAG GCTTGAAATA 62281 CTTTCCTGGG GAGATAAAAC ACAAAATGAA TTAAAGAAGG AAATCGTGGG TAGCTAGTTA 62341 CATTATTCTA CCATGATGTT TAAGGCAGCA TCCTAAGATT TTGGGCAAAG GACACTAGTG 62401 CAATAATCTT TATTTCAGAG TTTAATCAAA TAAATAAACA AATTTTAAGA CTTTCATTAT 62461 TTAGGTCAAA GAGAAAAGAC AGGTTTTAGC TACAATACAA TAAGAGCTTG TACAGATGTG 62521 GTTTTTATTA GAAGGCCTTT TGCATATCTG TGTTTCATGG CCCGAGGCTG CCCTTATAAA 62581 GCGTTCTGCA CTTACCGTTT TGGGAAGCAG TTGTTCAAAC ACAGGATCTC TCAGGTGGGT 62641 ATCACTGCTG CCTCTGTCTC AGGTCAGTAT AGGAGTTTTG ATGTGAAGTC AGCCAAGAAC 62701 AGCTGAACAC TACTTCGGCT GAGGCCCTTT TATAGGAGGG ATTGCTTCCT GTGAATAATA 62761 GGAGGATATT GTCCACATCC AGTAAAGAGG AAATCCCCAA TGGCATCCAA AAACTTTCCC 62821 GGGAATATCC ACGATGCTTA AAATTACAAT GATGTCAGAA ACTCTGTCTC TTGAAGCTAC 62881 TTCACCTTTG TCCATGCCTT TATATCTAT ATGCAATTTT ATTAATATGA CAAAAATGCA 62941 TGATTTTTAA TTATAATAAC ATAAAGTCTA TGTCTTTAAA AAGTTGTAAA ACTTTGCTTG 63001 TTAGTAGTGT CTCTCATGTA GTTGTGGTAG TAATTAGAAT TTCAGAAACA GAAGGAAACC 63061 AAGAATAGGT TTGTCATCCA TAGTCTACTA CCTTCAATTT CTCATTCATA GCTGTGGATA 63121 ACCAATCACT ACTCATTTTT TCTTCCTTTT TCACCTGCCA ATTCAACATA TTTAACATGC 63181 ACTGTCTCAC AGAGGAATGA CTCACAAGGT AGATATTAAT CTTCAGATTT TGCACGGCAG 63241 TTATGCCTAA ATTAAAATAT TATCTAAAAA TAATATCTAA CACTCAAATG GTTAAAATAA 63301 TGCCTTATTT TAAAAAAAGA AAAATGGGAA ATAGATATTT ACATCTGGGA AAGTTTCATG 63361 GTTTGTTCAG TGAAAAAAAT AAAAAGGAGG CCAGGCACAG TGGCTCACGC CTGTAATCCC 63421 ACCACTTTGG GAGGCCGAGG CAGGCGGATC ACCTGAGGCC GGGAGTTCAA GACCAGCCTG 63481 ACCAACATGG AGAAACGCCA TCTCTACTAA AAATACAAAA TTAGCTGGGC ATGGTGGCGC 63541 ATGCCTGTAA TCCCAGCTAC TCGGGAGGCT GAGGCAGGAG AATCGCTTGA ACCCGGGAAG 63601 TGGAGGTTGC AGTGAGCCAA GATCACGCCA GTGCACTCCA GCCTGGGAAA CGAGTGAAAC 63661 TCTGTCTTAA AAAAAAAAAA AAAAAAAGAA AAGAAAAGAA AAAAAATAAA ACGGAAAACT 63721 ATATATATAT ATTTAATTGG TCAAAATTTT GTTTAAAATT TTTGAAATGT TAATGTGCAA 63781 AGAATAAAAA TTCTTCCACA ATGTTAACAG TGACTAACTC TGGATGGCAG TATTTGGGAT 63841 AATTTTTATA TCCTTCATTA TTATTTTCAG GATTTTAAAG TTTTTTTCAA TTTCCCTTTT 63901 TTTCACCTTT ATAGTAACAA GAATACAGTT TAAAGAAACT TGTCTCTAGG CCAGGCATGA 63961 TGGCTCATGC CTGTAATCCC AGCACTTTGG GAGGCTGAGG TGGGTGGATC ACCTGAGGTC 64021 AGGAGTTCCA GACCAGCGTG GCCAATATGG TGAAACCCTG TCTCTACTAA AAATACAAAA 64081 ATTAGCCGGG GTGTAGTGGC GCATGCCTGT AATCCCAGCT ACTGGGGAGC CTGATGCAAG 64141 AGAATCGCTT GAACCCAGGA GGCAGAGGTT GCAGTGAGCT GAAATCACAC CATTGCACTC 64201 CAGCCTGGGC GACAGAGCAA GACTCCATCT CAAAAAAAAA GAAAAAAAGA AAAAGAAAAG 64261 AAAAGAAATT TGTTTCCAAA TGCAACAGAA GGAGATGTAT GTGGTATCCT ATATTCCTGC 64321 TCTTCATTTT GACATTTCTT CTGGGTGATT GTATACATTC CCCATCTCTG CATCTTACCC 64381 TATCTAAATG ATGGTAACAG TAAATGGGGA TCATTTTAAT TTCCATATTC TGTAGGTTTT 64441 CAGAGCTCAA GTCAAGCTAA TATTCTATAT CTACAGCCTT TCAAAATAGG AGGTCTATCT 64501 AAAAATGTAC TGTCAGCAGA CCTGAACGAG TAGTGGTAAA AGCCTCGTTT TTCTCTTTAC 64561 TTGTTAGCAC TGGTCTTTCT GTGTTCATAA AGATGTCAAG ACCCAAAAAA AAAACAAGAA WO 00/09525 PCT/US99/17712 EPI-109 628 64621 AAGAGAAGAA AAATTCCAAA AAAGACAACT GATTAGAAAA AAATAACTTA ATTAACGAAT 64681 TTAATTCAAC CCCTATCAAA AAGCATAGAA TTTATTCCCT CCACCTTACC ACTCTCTTAC 64741 ATGATCCAGA TACTGACATT ATTCCAATTC TTTATCCCAC TTTACTTAGC TCAATGTGGT 64801 TGTTGCTTCA ATAAATTCAG AAGAGTAATC ACTCATATAG TGTTTATTTA GATTTTAGGG 64861 CAGAATGTCA AGTTGGGTTA ATACATTATC TGTATGTATT TTATTTTTAA TAAAGTATGA 64921 ATACATAATC TGCTATTTTT AAAAAGCATG GTCAAATGTA TAGAGTAGCC AAATCTTAAA 64981 AAACAATTTA TCTTCGATAT CAATAAAGTA CCTAATAATT ATATTGCTAA TAGAAATTAG 65041 TCGTTAACAT CCCTAGATAA CTAACTTTAT TATTGCGAAT TTTTCATAAC TAAGTTTATA 65101 GTTTATCTCT TCCCCTTTTT AAAATTAGTT CAAAGATATC TAAAAATAGC CCCAGTGGTG 65161 ATGAAGTTTC TATTTTACTT ACATATATAT GTCCTGGACC CCCAATTATA ATCTCTAACA 65221 TTTATTGAGT GCTTACTATG TGCCAGGCCA TATTCTGAGC ATTTTGTATG TTCACCTATT 65281 GATTATTCAA TCCGTACAAC AGCCTATGAA ATAGGTACTC CTATTATCCC CATTTTACAG 65341 ATGAGGAAAT TGAGAATCTG CGGATTTTAT CTCATTCAAA AGCACAGAGC TAAGGGTTGA 65401 AACCAGGCAG TTGATATCCA GAGCCCACTC CCTTACCTGC TACTCCAAAC CATGATTTCT 65461 TTTGTTGTTA TGCCCCGAGA TTCCTTGTTC TACCCAAGTT TCCTGTACTC TTCTTGCCCT 65521 CTTCTTCCTG AGACATCCTT GACCATCACA GCTCTCCACT GAGATAACTG TGTCCTGGGT 65581 TCTGAGACAT GGGGGCTGGA AGGGACCCCA GGGACAGTGA GCAGTAGGGA GAGGATGCAG 65641 TGAGAACAGA CCCTGGATCC CCGGTGCATA GGCAGGGAGA AAGTGGACAA AGGAAAAAAC 65701 AAGCAAGGCA GGTGGAGCCA TCCCTAGGTA AAGTTGATCC CTAAGCCACA GTTCCCAGAA 65761 GTTCCTGATT CAAAAGCAAA TTTTCTCTAA GGTCAAAGGG CAAACTGATT ATTCTAAATT 65821 CTAAACTGAT TATTTCTAAA TTCAGAAAGC TTCAGGGAGA GATCCCAATA TTCGAAGGAT 65881 AAGAGAAATG AGGAGTGGAA GAGATAGGTG AGTAACAGTA ACTTAAATGT AGACTATATA 65941 TAATATATAA TATATGTAGA GTATATATAT ATAATTACAA TATATTATAT ATGTGGAATA 66001 TATATATTAT TTATATATAT TTATATATTT TATATATATA GATATTTTTA TATTTTATAT 66061 ATAAATATAG ATATTTTTAT ATTTTATATA TAAATATAGA TATTTTTATA TATATTATAT 66121 ATAAATATAT GTAAAATACT GTGAAAGAAG AATAGAATCT TGAGACCTCA AATTCACTAT 66181 GCCAAAGGGA AAGTTAAGCT TGGGAAATGA GTCATGCAAA AACTGCCTTC CTTTTGTTCC 66241 CAAATACCTC TAATTTCACA TGCTTACTTT ATCTTATATA AAATGTAGAT GTACTGAGCA 66301 TGAGATCCAT GCATAATTTC CCTCTAGTCC CTTCTTTTTA CATGTAAAGT GTAGACTCAC 66361 TGAGTGTTAC AGAGCCTTGC CACAATGTAA ACACTTGTCT CATTGCCAAC CCATCTTTCG 66421 TTTATTTTCT TCCCCTCCTG CTTGCTCTTT CCCCTCTAAA GATGGAAGTT CCCAAAACTC 66481 TCTTTGGAAA AAGCGCAGGT CACAGATCCT ACAGTGATTT GTGTTTCTTT TACCTGGGAC 66541 AAAATAAACC TCTAATCTGT TGAGATATGC TTCAGTTACT TTTTGGTTTA CAATATGTAC 66601 ATGTATGTAT ATAATTTATA TGTATATAAT ATATGTACTT GTTTTAACCA GAGGTATGTT 66661 ATTCAAAATC CATTCATCCT TACAATTACC TGCATTCTCC CACAGTATTT TCTGTGTCCC 66721 TGCCCCCGAG GTTGTCACTG CAAATCAGGT ACATGGATAC TGGGAGCTGA TGGACTCCCC 66781 TCTGGCTACC TGGGCTGCTG AAGGGGCCAT AGACAGACCC AGCTTTCCTC TCGTGGAGAG 66841 GCCCTGGGCC AGCGCTGCGT GGGAGTGGGA TTACAACCAG ACTATAGCTT CTTCACCTGC 66901 TTTTTCCTAT CAGGATTTCA TAAGAGGCAA TTGCTTGTTT TTTGAGGGTG GGGGCAAATC 66961 AGGGGGAGTT GAAGAGGAAA TTGGGTAAGA TTTGAATAGT TGGGCATGTT GAATATTATG 67021 AATATCATCT CCCTCTTCAA ATAATCCAAA ATATACCCCC AAGAAACAGG CTGATTAGAG 67081 GTGCTTCAAG GCTCCACTGA ATCTCCCAAG CTCTGAAGAT GTACGCTAGCT GTTACCGGAT 67141 TGCCGGTTTT CAAGCCTCGC CTCACATGGA CCCTCTTGGC AGTTTCTCGC ATGGGGAAG 67201 CATCCGCTAC ATAGATGGGA ATGAAAAGAG GAAAGAAGAC GGTGCAAACT CAGGCACACC 67261 CCGGTCTCTG CCACCAGTGC TATTTAATCT CTGAGGTGTC ACCCTTCCTG GCTTTATTGT 67321 CTCTTCCTGG AAGTCTCTTG TCCTCTCCTC CACACCCTTT AATCAGGCAT CAAAGACTTT 67381 AACCAGTTTT GCTGTGTGCC CAGGCCCACT CATTCTCACT TTTATGGCAA AGGGAGTGGG 67441 AGACAGAGAG ATAGCCAGAA AGAAGAGATT GGGGACCCCA AGACAAATGT TAGAATTTTA 67501 ACCAAGGCCA CCCTGTGGAC AGGAGATTAT TGGGTTTAGT GGAAAGCAGC ACTGGCCACA 67561 ACCACACGTG GCAAAAGCAT CTATCGAGGA GTGAAGTTAT ATTTGGTGAA TGTGACCGGG 67621 AAGCAGGGGC AGTGGTGTCC TCCTGCCTTC CTGAGGCACT CTGTTCCCTT ACCTCTGCGA 67681 AGGCTTATTT TACCCCTGAG TGCTTAGTTT TGAAAGCCTT AGTTCCCTCT CTCCCATAAA 67741 AAAGCTCTAC TCTGCTAACA TCTAAGTTAC CTTTGCAGAG TCTTAGGTAG AGGGAGGAAA 67801 TCCCAATAAA GATTCCACCC TATCTGCAAA ATACAAACAT GGTATTTCTT GCATTCCCAA 67861 AATTGTGAAA GAAAATGTGT ATCACCACAG TAGAGAATGG CATTTTTTGT TTGATCAAAA 67921 CCTAAATATA TTTGATGAAA ATGTGTCTGG TTCTAAGTTT ATTTCCCAGA AAGCCATGTT 67981 TACTCACTTG GAATTTATAG ACATCTTATA ATATCTGAGT CGAGTAGGAG CTCCGGGCTC 68041 TACCTCACTC TTTTCTCCCA CACCCAGGGG GAAGTGTAGG GTTCTCAGAC TTTAGAATAA 68101 AGAGGAATCA CCTGGACAAC TCACCTAAAA TGCACATCTT CAGGTCTCAT ACTCAGAGGC 68161 TCTGACTCAA CAGGTCTGGG TGGCGCCCAA GAATTTGGGC TTTAAATGAG TATCTCAGAT 68221 GATTCTAATA CAGAATGTGT AAGATGACCA GATCCTATCA CACTTAGATG TATTGGCCTA 68281 GGGCCACCTA ACTTGGAGAA AATGTTAGTA AGACCCCGTG GTTGGTGCTC AGCTATAGGT 68341 ACCAGAATTT TGATCAAAAT TTACTATCAT TGTGACACTT CTCTTCGGAA CTGGAAGGCC 68401 AGAACCCCAC TTGTAAAGTG CTGGGAAAAT ACAAGGAAAA TTTAGGGTGA GTAGCATTTT 68461 GAATTCTTAC ACATGGAAAG TAAATGTATA AGAATTCTTA CCAATAAAAA AAAAGCAAGA 68521 GAGAATAGCT 'GCTAAAGAAT TAACACAAAT ATGTATATAT TAGTTATTCT CTTTTCTCCT 68581 CTGATTCCAG AGGACTTTGT AATTCCACTA ATTCTTCTTG AGCTTCCAGG ATGATCTGAG 68641 ACTTGAATTT TTCATGTGCT TTTTGCTTCC TATTTGGCAG CATCTTATCT TGAAGTTTCC 68701 GCTTTCTGCT TGGGGACCTA AAAACTAACT AATGGGAATT TCTTCAAAAT GAGCAAACTC 68761 TGGTGAATTC CCAAAGCGGA AGAAACAAGT GAGGATCGGG CTGGTTAATT AAGAGAACTT 68821 TTCCTGAATG TAGCCAGACT GTTTGCCGAC TGTTGTTAAC ATGAGGGAAG AAATACCCCT 68881 GGATTTTAGA AGAGCCCCTT GTTTGTTTTC CTTGGCCATT TGTGCTGCTT GTTTTGTAAG 68941 TCAGAAATTT CCTGAAGGAC TATTATTAGC TTTGTTCTCA CGTCAGAAAA CTTCTGCTCT 69001 GGCCACTTTT AAACATATAA CTTGGATTTT ACTGTATTAG AAAATGTAAC AATTACAGAC 69061 AGCACTAAAA GGACACCAAA GGGCAAAGAA AATGGGTAAC TTTTTTTTCT TCCCCAAATC WO 00/09525 PCT/US99/17742 EPI-109 629 69121 TAAAATAGGT GATTTTGGAG AAGTAGGAGA AAAACCTGGA TTTTCTAGAT CTCTTTAGAG 69181 CTCAACAACT GATATAGTTA ATTATGTAAG TCTTTGATAT TTGGAAATGA TTGGATTAAC 69241 CGGATAACAA TGAATATTTA AATACAGTGA TTTGGCCACG AGCAGTZGCT CATGCCTGTA 69301 ATCCCAGCAT TTGGGGAGGC TGAGGCGGGT GGATCACCTA AGGCCGGGAG TTCCAGACCA 69361 GCCTGGCCAA CATGGTGAAA CCCCATCTCT ACTAAAAATA CAAAATTAGC CAGGCGTGGT 69421 CGTGCAAGAC TGTAATCCCA GCAACTCGGG AGGCTGAGGC AGGAGAATTG CTTGAACCCG 69481 GGAGGCAGAG GTTGCAGTGA GCCAAGATCA CGCCATTGCA CTCCAGCCTG GGCAACAAGA 69541 GCGAAATTCC ATCTCAATAA ATAAATAAAT AAATACAGTG ATTTAACACA AGAGATTTCT 69601 ATTTCACACT AATGAGCTCT GTCACTGGGG CAAGCTTCTT TGCCTCATTA AGTCTCAGAT 69661 TTCCCGAGAG CTTATTTATT TATACCAAGA GTGCTTTACT ACCGTCTCTG CTAGCTGTGA 69721 CATAATATGA CAAAAGGTAT AAATATGGGA AAAGGCACTA ATTTATATCA AAGCGTTCTT 69781 CGTTTTTCCT TGCTGTGAAG TTTTTAGCTA ATAATTCATA AGAATATACC ATATTTAGAG 69841 TGTTTACTAT GCATGGGCCT GGCACTTCAC ATACATTGCT TCTTACAAAT TTTACAAAGT 69901 GAAAGGTAGA TATTAATCTC ATTTTATGGA GGACAAGATA GAGATCTGGA GAGGTTACAT 69961 AACTTGCCAG TGTTTTTTCA GTTAATAAAT GGTAGGGTGG AGATTCAATC TGTGTTACTC 70021 TAAAGTCCGT GTCCTTTTTA TTGGCTCCAT GCCTACTCAG ATTTAAATCT CAGCAGGGAA 70081 GTAAACCTTA GTTTTTACAT GAGAAAATGT TACAGCAGCC TTCTCGGCTT CCTTTACCCC 70141 CATCCCAGTT TCACGAGCTT AGTGCCTTAG ATCGGGTTCC TTTAGAAGCA GACCTCGAAA 70201 TAAGGATGTG GGTGCCAGTC ATTTATTGAA AAGATGATCC CAAGAAAGCC TACTAGGAGA 70261 GTGAGGAAGT GAGATGGGGA AAGGAAGAAA CTCCACAAGA AGTGTGTTAA TAAGCAGGTT 70321 ACCGCTGTGG GCAGCCATGG GGCTCAGCTG CACTAACAAA CTCTGTCTAG TACAGAAAAC 70381 CTCAGGGTCT CCCCAAGGAG GGGCAAGAAG TCTGCCTAGG GTATATATCC GCCAACTCAG 70441 TCACTGGCTG AGAGCTGATC CTGGGAGGGC ATGGTTAATT CCTCTGCACT TTCAAGTGGA 70501 TTCCTGTGGT CAGAAAAAGC CCTCTACAAT GAATTCCAGA TGCTTGTATT TAAATCTGAC 70561 ATGATCTGAA TGCTGTGTTG GGACAGGGTG GGCGTTATTA GTTTTCTGTC ATTACTGTAA 70621 CAGATTACTA CAAACCTGAT GGCTGCAAAC AACACATATT TATTATGTCA TAGTTTGTGT 70681 GGGTCAGAAG TACAGGTTAG CTCAACTAGT TTCTCTGCTC TAGGTTTCAC ATTGCCAATA 70741 TCAAGGTGTC ATCCAGTTGG GCTCTTCTTG GGAGGCTTGG GGATGAATCC ACTTTCAAGC 70801 TCATTCAGAT TGTTGGCAGA ATCCAGTTCC TTGTGGTTGC AGGACCAAGG TCCCTGTTGC 70861 CTTGCTGGCT GTTGGCCAGG AGTCATTCTT AGCTTCTAGA GACTACCTGT ACTCTCTGAC 70921 TCGTGTCTCC ACTTCACCTT TCAAACCAGC AGCGGCTAGT CGAGTCCCTC TCTTCAAATG 70981 TCTCCAACTG TGCCTTCACC TCATTTCTCC TCTGTGTACC ATGTCTGCCT CTACTGCTTG 71041 TAAGGGCTCA TGGGATTACA TTGGATTTAT TCAATCCAGG ATAATCTCCA TATTTTAAGG 71101 CTAGCTGACT AGTGATCTTA ATTCCATCTA CAAAGTCCCT TCCAATAGTA CTGTATTAGT 71161 CCATTTTCAT GCTACTGATA AAGACATACC CAAGACTGGG CAATTCACAA AAGAAAGAGG 71221 TTTAATTAGA TTTACAGTTC CACATGGCTG GGGAAGCCTC ACAATCATGG CAGAAGTCAA 71281 GGAAGAGCAA GTCATGTCTT ACATAGATGG CAGCAGGCAA AGAGACAGAG CTTGTGCAGG 71341 GAACTCCTCT TTTTAAAACC ATCAGATCTC ATAATACTTA TTCACTATCA CAAGAACAGC 71401 ATGGGAAAGT CTTGCCCCCA TGATTCAATT ACTCCCACCA GGTCCCTCCC ACAACATGCA 71461 GGAATTCAAG ATGAGATTTG TGTGGGGACA CAGCCAAACC ATATCAAGTA CCTAGATTCA 71521 TGTTTGATTA AACAACCAGG GAGCAGAAAT CTTCAGGAGT GGGGGGCATC TTTAGAATTC 71581 TGCCCACCAA GGCTGGGCGC GGTGGCTCAC ACCTGTAATC CCAGCACTTT GGGAGGCCAA 71641 GGTGGGTGGA TCATGAGGTC AAGAGATCGA GACCACCCTG GCCATGGTGA AACCCCATTT 71701 CTACTAAAAA TACAAAAATT AGCCAGGTAT GGTGGTGGGC ACCTGTAGTC CCAGCTACTC 71761 AGGAGGCTGA GGTAGGAGAA TCACTTGAAC CCAGGAAGCG GAGGTTGCAG TGAGCCAAGA 71821 TTGCGCCGCT GCACTCCAGC CTGGGAGACA GAGCAAGACT GTCTCAAAAA AAAAGAATTC 71881 TGCCCATCAT AGTAGGCTGT CCTACAGAGA CATAACCCAG GAATTAGGTG AATGGCTAAC 71941 CTAAATTAGC ACTGTGATGT GTTTTCTGAC TTGGTCCTTA TAGCTCCTCT GCTTAGATGT 72001 GGAACTAATC CATGAATGCA AGGGTTTGTC TAGAGTTTTA AGTGGGAGTT AAATATCCAA 72061 AGTACAGGAG ATATTATGGG TGCCTCATCC ATGTCCCCTT GGCATTTATC TTTCTTGGAT 72121 AACCCAACTC TATTAGTTTT TATATCTCAC TTGTTCCTAT ACTCTGTGAA CTGATGTCCC 72181 ATAAATAGAC ATTTCATTTT GCCAGTCTTC TTGAACAATA ATTACGATTA TTAATCTAGC 72241 AGTTATCATT AATTGGCCAC TTCACATTAG ACACAGCACT TAGGACTTAA GAATACCATG 72301 TCATTTGATC ATCATAATAT GGTCAGGAAT TAAGTATTGC TATCCAAATT TTACAAAGAA 72361 GGCACTGAGG GTTAGAGTTT AAATAACTTG CTTAAGATGT CATAGCCTGT AAGTGACAAA 72421 ACTAGGACTC AAATACAGGT CCATCTGACT CCAAAGTCTA TGTTCTTGGC TACCACACTG 72481 CCTCTCCTAC AAGTGACCTG TGGTTTTACT ACTATATTCA CACTCTACTA ACTTTACCAT 72541 CTCCCATGAG TCTGTCTAGA GGAGGGCACA CACAGCACAG AAAACACATG AATGCAAAAT 72601 AAGGAAGGGC CTACTTACTA CACAGAGCCA TTCTAATACC TGATGTTTGC TCTAATCCAG 72661 TTTTACTATT AATTAGTTGC TGGTGCCCAA GTTTTTACTG AGAAATGGGG ATAATTTTGG 72721 AAGTCATAAT GATGCCTTCT TCTCATAGGG TATTTTATTT GTTGTTGTAT CTCCAGGCCC 72781 CAACACAGCC TGGCTTTTAG TAAATGATCA AAAATACCTG TTGAATGAAT AAATGGAGTC 72841 ACCTGAAACA TGTTAAACAT TTGTTCATGT GTCCTAATCG TGGATTTCAG GATAGTAAGC 72901 ATCCTAAAAG GAAAGCATGC ACACTGTTCT TGCTACATTA ATTTCTCACA ATATAAAAAA 72961 AGAAAAGCAT CTGAAAAAAG CTGCCAGCCG CTGTGTCTCC TAATATCAAA CTGAGCACAG 73021 ATATGGAGAA GCTAAGGGAG AGGGATGATG GGCCATGCCT CTAACCTCAT CATGGCAAAA 73081 GTCCTGGGGG TCAGACCCGA GGAGAGCAGG AAGTGTCTTT TGAGGGATAC ATTTCCACAG 73141 TGGAAATAAT GAGACTTAAA TAAATATTAT ATACACAGTT CAACTGTTTT TATGTGTAAA 73201 GGTAGTAGGT TTTCACAGTA AGGAAGCACT TCTTTTTTTT TTTGTTTGAG ACAGAGTCTC 73261 GCTCTGTCTC CCAGCCTGGA GTACAGTGGT GCTATCTCGG CTCACTGCAA TCTCTGCCTC 73321 CTGGATTCAA GTGATTCTCC TGCCTCAGCC TCCCGAGTAG CTGGGACAAC AGGTGTGTGC 73381 CATTACACCT GGCTAATTTT TGTATTTTTA GCAGAGATGC GGTTTCACCA TGTTGGCCAG 73441 GCTGATCTCG AACTCCTGAC CTCAGGTGTT CTGCCCGCCT CTGCCTCCCA ATGTGCTGGG 73501 ATTACAGGCA TGAGCCACTG CACTCACCAA GCACTTCTAC TGATAGCATT TACAAACCCT 73561 TCTTAGAATA TTTAAAAATT CTAAGAGAAG AGTAAATTGA GCCTTCCCAA CTAATACTAG WO 00/09525 PCT/US99/17712 EPI-109 630 73621 GAGGTTATAA CCTTCA:ACC AAAACTGGAC AATGCTTGCA CAAAAGAAGG AAGCCAATGA 73681 GGCCACCTAG AAGGAAGACT GGGCATTGGG CCCAGTGAGT CCTCGAAACC TCATCTGTGC 73741 CAGCCACCCC GGCATC-CCT GTATGAGTGG ATGAGGGTGA CTTGTCCACA GACAATAGCC 73801 ATCTAGCTGT GATAAAGGAG TCAAGGTAGT CAGCTGCATC TCTTTCACCT GTTTGCCAAT 73861 GTTACACAGG TTGAAAAGCT AAGGTTTATG TAAAGCAAGC ATCAAAGATG ATGAAATGAT 73921 CAACCTGACA ATGAGTACTA TGCTGCATTG TCCAGAAAGG AACTGTGGAA GATTTTGGGC 73981 TGAATTTCAA AACAGAATTT CCTCACTCTC TGGATGTTGG CTTACTTGGC CTTTGATGTT 74041 CAGAGGTGGT GCCTTTSTGT TGTTGAACAA TGTTGATTTT GGAGAGAAAA CAGAGTTGAA 74101 AAACCCACAA GTCATTCCCT GGGGAGTATT ACCGGAATAC AGAGGATAAT TTCAGCAAGC 74161 CAGCAAGGCC TCATCTCTGC TTCTAATAGA TAGGAAGAAA GCAAGAGAGG AACAATACTT 74221 TTTTAAGAAG CTCAGCTTTA TCGCCTTATC TCATAGAAAG ATGCCTCCAG TCTGTCTGGC 74281 TAAAGGTAAT TGGCATGGGA AAGTCTTTAT CTGTGATTCT AACAAGTGGA ATGTTTCCCT 74341 TCATTAAGAG AGCCTTGTCT GGCTTGGGGA AATGAAACAC TTTCTCCGAT ATGAGTGGGC 74401 TGTAACCCCT GCTACTAAAT ACTCAGAAGA AATAAGGCGG TTGTGGAGCA GTCAGGAATG 74461 AGTCACTTGC CTCCCTGGAA TATTCAGAAA ACTGAATCAA AAGTACATTC TTCTGGGTTT 74521 TCTTAGTCTA ATAGACTAAG GGTCTCTACT TTGTTAAATT TCTGGGAAAC AGCATAGAAT 74581 GGGAGAAAAA ACTGGTCACT GTAGTCATGC AAATCTGCAA AACAAACAAA AAAGTCTGGG 74641 TATTGCTGCT AACTAGCTAT GTGACCTTAA GCAAGGTATT AACTCTCTCT GAATTTCAGG 74701 TTCTTCATCT GTTAAATAGC ATATCTGTAA AATGGGAATT ATTTTCATAT CATAATGCTG 74761 TAGCTTTAAA AAATAAAATA AAATGGATGA GATAATCAGA ATTAAAGAGC CTGGGATATA 74821 TAGTTAATAT ATAGCAGCAT GTAAAGATCC TGTTAGAAAT GCTAATTTTA CAGTTAACCA 74881 TTTGGAGATG ATCCGCCAAA GCTGCTAGTG TAGAGGCAAC TGAGAATTTG CCTGTCCTTC 74941 AGAATATGAA TAAATAACTG TCAATGATGT CTCAAGCCTA GAAAAACCTA TCCATCTGGA 75001 TGGGTGGGAA ATTTCTAGGC TAGTATTGAG AAGCCCATTT CTTGGGAAAT AGGTCCTGGA 75061 CTGAGTGAAG GAAAAGAAAC AGTAAAACCC ATGGTAAAGC AGCAAGGCTC TCTAGAGGCT 75121 CTGGAGAGGA TGAATTGAAT TCTAGAAGAT GAAGTAGGGA AGACGCTTTA CCTTCTTGTG 75181 AAATGGATTC AAAGATTCAA AGACCTTCCG GAATCTCCAA TTGTATAAAT GGCACCATAG 75241 CTGTATGTTC CATGGAACAC TACTTCCCAG AGATGCCCAG TGAAAAAAGA ATGCCACAGT 75301 CAAATAAGTT TGGAAACACT CCATTATGTG GCCACCTCCT TGAAGACTCT AATGCACATT 75361 AGCATGTTAA ACAGTCTTGA GAAGTCCTGC AGAGCAGAAA TTGCTTCACA TCTGCTAAGC 75421 CGGCAGTTTC CCAATATACT TGATTATGGA TAGTTTTTTC CTTACAACAC CATTCTCTGA 75481 TATGCTTCCA ATGACATGAA ATAAATATAT ATGCATGAGG TTCTTCATTA GGGCATACTT 75541 TTTAATAGAA AATATTGAGA ATAATCTAAA TATAAATGCA CAGCATTTAC CTTTTCTGCA 75601 TAAACTATAT ACAGGCATAC CTTGGAGATA CTATGGGTTT GGTTCCCACA ATATCTCCAA 75661 AACCACATTC GGTTTTATGA CCACTGCCAT AAAACCAGCC ACATGAATTT TTTGGTTTCC 75721 CAATGTATAT CAAAGTTACA TTTTTACTAT ACCATAGTCT ATTATATATA CAATAGCATT 75781 ATATCTAAAA AACAACGTAA ACACCTTAAT TTAAGGCTGT GGCTGGTTTG ATTTTCTACC 75841 CAGACCACTA AAACTTTCTT CATATCAGCA ATAAGGCTGT TTCACTTTCT TACTATTTTT 75901 TGTGATAGCA CTTTTCCTTT CCTTCAAGAA TTTTTCCTTT CTATTCACAA TTTGTTTGAT 75961 ACAAGAGGAC TAGATTTTAG CTTATCTCAG TTTAAGGTGT TTACATTGTT AGCTAAAAAT 76021 GCTAATGATC ATCTGAGACT TCAGCAAGTC ATAATCTTTT GCTGGTGGAA GGTCTTGCCT 76081 CAGTGTTGAT GTCTGCTGAC TGGGTGGCTT TGGCAATTTC TTAAAGTAAG ACAACAATCA 76141 AGTTTGACAT ATCAATTGAC CCTTCCTGTC ATAAATGATT TTTTTTTTCT CTGTAGCCTG 76201 CAATGCTCTT TGATAGCATT TTACCCACAG TAGAATTTTC AAAATTGGAG TCAATCCTTT 76261 CAAACTCTGG TGCTGTTTTA TCAACTAAGT TTATGGAGTA TTAGAAATCC CTTGTTGTCA 76321 TTTCAACAAT GTTCACACCA TCTTCCCCAG GAGTATATTC TACCTCAAGA AACCACTTTC 76381 TTTGCTCATC TATAAGAAGC AGCTCCTCAT CCACTAAAGT TTTATCCTGA GATTGCAACA 76441 ATTCAGTTAC ATCTTCAGGC TCTACTTCTA ATTCTAGTTC TCTTGCTGTT TCTATCTCAT 76501 TTGTGCTTAC TTTCTCCGCT GAAGTCTTGA ACCCCTTAAA GTCACTCATG AGGGTTGGAA 76561 TCAACTTCTT ACAAACTCCT GTTGATGTTG ATATTTTGAC CTGCTCCCAT GATTCATGGG 76621 TATTCTTAAT GGCATCTAGA ATGGTGAACG TTTTCAGAAG GTTTTCAGTT GGCTTTGCCC 76681 GGATCCATCA GACGAATCCC TATCTATGGA AGCTATAGAT TTATAAAATG TATTTCTTTT 76741 TTTGTGGGGG CATAGCGTCT CACCCTGTCA CCCAACCTGG AATGCAGTGG CACAGTCATA 76801 ACTCACTGAA GACTCAAACT CCTGGGCTCA AGTGATTCTT CCACCTTCGC CTCCCAAAAC 76861 ACTGGATTAC AAGCTTGAGC CACTGTGTCT AGCCCAAAAT GTATATCATA ACTAATGAGG 76921 CTTGAAAGTC AAAGTGACTC CTTGATCCAT GGGCTACAGA ATGGACGCTG GGTTACCAGA 76981 CATGAAAACA ATACTCATCT CCTCATACAT CTCCTTCAGA GCTCCTGGGT GAGCAGGCCC 77041 ATTGTCAAAT GAGCAGTAGT ATCTTGAAAG AAATTTTTTT TCTGAGCAGT AGATCTCCAC 77101 AGTGGACTTA AAATAGTCAG TAAACTATGC TGTAAACAGA AGTGCTGTCA TCCAAGCTCT 77161 GTTTTTCCAC TGATAGGGCA AAAGCAGAGT AGATTTGGCA TAATTCTCTA GGGCCTTAGG 77221 ATTTTTGGAA TGGCAAATTG AGCATTGGCT TCAACTTTTT TTTTTTTTTT TTTTTTTGAG 77281 ACAGAGTCTT CGTCTGTCAC CCAGGCTGGA GTGCAGTGGT GCAATCTCGG CCCACTGCAA 77341 GCTCTGCCTC CTAGGTTCAC ACCATTCTCC TGCCTCTGCC TCCTGAGTAG CTGGGACTAC 77401 AGGCACCCGC CACCATGCCC GGCTAATTTT TTGTATTTTA GTACAGACGG GGTTTCGCCA 77461 TGTTAGCCAG GATGGTCTCG ATCTCCTGAC CTCGTGATCC ACCCGCCTCG GCCTCCCAAA 77521. GTGCTGGGAT TACAGGCGTG AGCCACAGCG CCCAGCCTGT CTTCAACTTA AAGTCGCCA 77581 CTGTGTTAGC CTCTAATAAG AGAGTCTGCC TGTCCTTTCA AGCTTTGAAG CCAGGCATCA 77641 TTCTCTTCTC TAGCTATGAA AATCTTAGAT AGCATCTTCT CCCAATAGGA AGCCATTTTT 77701 TATGCCCTAA AAATCTGTCG TTTGGTGTAG CCACCTTCAT CATTGATCTT ACCTAGATCC 77761 GCTGGATAAC TTACCACAGT GTCTACATCA TTACTTCTGC TTCACCTTGC ACTTTTATGT 77821 TATGGGGATG GCTCCTTTCC TCTAACCTCA TAAACTAACC TCCACTAGCC TCACATTCTT 77881 CTTTTACAGC TTCCTCGCCT CTCTCAGAGT TCACAGAATT GAAGAATGTT GGGCCTTGGA 77941 TTACACTTTG GTTTAAGGGA ATGCTGTGGC TGGTTTGATT TTCTATCCAG AACACTAAAA 78001 CTTTCTTCAT ATCAGCAATA AGACTGTTTC ACTTTCTTAC TATTTTTTT GATAGCACTT 78061 TTCCTTTCCT TCAAGAATTT TTCCTTTCTA TTCACAATTT GACCTTTCA TATGAGAGGC WO 00/09525 PCT/US99/17712 EPI-109 631 78121 CTAGATTTTA GCCAATC:CA GTTTACACCA TGCCTTTTTC ACTAACCTTC ATCATTTTAG 78181 CTTTTTATTT AAAGTAAGAT GTGTGACCCT TCCTTTCATT TGAACACTTA CATGATGATG 78241 CCTGGCTTCA AAGCTTGAAA GGACAGGCAG ACTCTCTTAT TAGGGGCTAA CACAGCTGC 78301 GACTTTTAAG TTGAAGCCAA TGCTCAATTT GCCATTAGAA GCCATTGTAG GGTTAATTAA 78361 TTTGCCTAAT TTTAATATA TGGTGTCTCA GCAATAAGG AGGCCTGAGT AGAGGGAGGG 78421 AGATGGGGAA ACAGCCASTC ATCAGAGCAC ACACAACATT TATCAATTAA GTTTATCACC 78481 TTGAGGGCAC AGGTCATSAT ACTTCAAAAC AATTACAATA ATAAAATAAA AAATCATTGA 78541 TCGCAGATCA CCATAACAGA TATAATGATA ATGAAAAATT TGAAGTATTG TGAGAATTAC 78601 CAAAACGTGA CACACAGACA CAAAGTGAGC ACATGTCATT GGAAAAGTGG TGCTGATAGA 78661 CTTACTTCAT GCAGGGTTGC CACAAATACT CAATCTGTAA AAAATTCAAT TATCTACATA 78721 GTACCATAAA AACAAGGTAT ACCTGTTTAT ATAATCAAGA CCAACAGAAC CCTAGAGAAA 78781 ATAGCTCACT CCCTAGCTCG GAGACATTCT AACCAACATA CACTTACCTT TCTTTTTGCT 78841 GTGTACAGAA TTCAAATCCC TGTCTCAGCA AAATTGCAAA GTATCAAATG TCATGTCCAT 78901 CTAATACTCA AAACTGCAA TGTTAAGTCT TGTAAGCCCA GAGACCACTG TATATACAAG 78961 TGTTGCTATA AGCATTAGTT CTTCTCCAAA GAAAATAGTC CACTTGGTAG AAACAAACAA 79021 AAAGAAAAAA AAAGAAACAA AAAACATTTT TTACAAGAAG ATTCAGTCTC TTACCTACAT 79081 AAGCAAAAAT ATGAGATGTT CTCTTATCAT TTTTCCATCT ATCTTATAAT CTTTGGTGCT 79141 GACTTAGACA CTCATTTTCC TTTTTGTACG TGACCATGTA AAAGTTCAAG TCAAGAAAAA 79201 CTTGTTTTGA CATTTGTTT GCTGAGTGAT GGGTCCCTAA AAGAAATTTG GCTTTGCTTT 79261 TGAAAAGTTC AGCATGATAT TGTGTGAATT TTTCATGGCT AATGATTTTT AGAACAGTTG 79321 TGATGTGTTT AGGTGTTTTA AGAATATGAA GCATTCAGTG GTTTAAGTTG GTTGTTATAA 79381 AATGAAAGAA TATGAAGGAA AGCCTTCTTG TCTTAGAACA CACTGATTCA CAAATAAGCA 79441 GCTTCTCTCA AAATGTTGTA ATTACAAAAA TTCCAAGGCA AATATAATAA ACTCCTTGTC 79501 GGTGCTATGT CTAGAAACTT AACAGCCCCA AAGAAAGTCC TGACAAGGCA AAAAATATAT 79561 ATATATATAC AAATTGTGGA AGCAGGGTGT TGAAAGAAGA ATAAAGACTA TATAAGGACA 79621 AACTGTTTAA AAGGGAGGGT ATCCTTGAAA GCTTGACACT TGACTCTTTT GACGAGGCTG 79681 AGGGAAAACA CTCAGTTTCA TAGATTGCTG GTACGGATGT AAAATAGTGA CATCCCTATA 79741 GAGAGGAATT TCGCAATATC TAGCAAAAGT GCTTATGCAT TTATTCTTTG ACCTAGTAAT 79801 CCCGCTTCTA GGATTAGTGG TGAAGATACA CCTCAACAAT AAAAATATAT ATACATTAGG 79861 TTATTAGTTA TGGTTTAATT TTTAATAGCA AAATATTTAA AACAACCTAC ATGAACAAAT 79921 AGGAGACTTA CTGAATAAAC TATGGTATAT CTGTACAATA AAGTGCAATT CACTTATGTT 79981 GTTAATTTGT TCCAAAAATC CAGAGCCAAA GAGTATTTGT TATGCTCTCT TTAGTATAAG 80041 APAGGGGAAA TAAGATATGT GTGCATCTGT TTATTTTTGT GAAAATAAGT ACAGAAAGGA 80101 TAAGTAAGAA ACTAGTAAAA CTAGTTATCT CCTAGTGTTA GTAGAAATAG AATGAAAGTG 80161 AATTAGGCTT CTTTGAGTAT ATGTTTATAT ATAGTTTTGA CTTTTGAATT ATGTTTATGT 80221 TTACATAGTC AAAAATATAA ATTAATCAAC AGAAATAACA AAAAAAGAAG AAATCACAAG 80281 CTTTAAAATT TAATACAAAC AGAAATAATT GAATCTAACA GTATATCAAA GTGATAACGT 80341 AAACTCAGAA GAAAAAAACA TAATCCAACA TACCAGTGGA ACACAATATT CTAACTGTAT 80401 ACATTCAGTG GTTATAGTCT AAGGACAAGA AAAATTGCAA AAATATCTTG AACTTTAGCT 80461 TGTAGGATTT TTATTGGTAG CAATACTAAT GTACTAATTC TGAAATTAAT GTTCGTGTAT 80521 TATAGAATTG AGTAAATGAA TAAATATGTT GATGTTATTG GGAACTAAAA TTATCATTCT 80581 GGGAGTAGAG AAATATAAAT ATGGACTTGG CAAATGAAAC AAAGACCTGC AGAGAGATAA 80641 CCATATAAAC TCATTATTTT AAAAATTATA AGTGTCCTAG CTCTGTTACT GAAAAGGCCT 80701 AGATTCAATC TTATCTTGAT AGACAGGAGG GCACCCCTTT CTCAGAACAT CGTTTCCAAA 807 61 TGCCATTCTC CATTAAAAGG AACAAGGTCT TCTTGGAGAA AAGACTGATT CTAGGTCTGG 80821 ATTAGGTAAA GTACAACGTT AGTCTGGAAT TTCTTGCTGA ATCAGAAGTA AGAAAGTGCT 80881 CAAAAACATG GGAACATGTC ACAAACACAC GTGAGGCAAC TTGAATCCTC ACTGGCCATA 80941 TTTAGACAA TCGAGCATCA AAAAAAAAAA AAATGTTGAG AATAATGGAT TCTAACACTT 81001 AAAACAAAAA ATAATCCATA GCCCACAGAA GGGGAAGAGA GGGGAGCTC TTATTTACAG 81061 ATCAATATCA AATAGCAAAG ACAGAAGAAA TGACAGAATT AGAGAAACAT CATTTTGCAA 81121 AACACCACTG TAATAATCAA TTCAGGCAAG TATTATTAAT GGATGTATTA CTATTGCGTA 81181 AAACCAGTTG GGGAACAGGA TATTCATACA GTCTGAAGGT GTCACCCTAA ACATAACTTA 81241 TTACAAGTGG AAAATGGTGC CTTTACAATG AAGAAATCTA GCAGAAACCA TCTTAATCTA 81301 GTGATCAAAC TTAGTATCAC CAATAATGGA TCATACTGAG TCATGTGTCT CCTAATATGA 81361 TGCACCAGGA AGGATGCAAC GTCATGAACG TTGTATTCTT TTGTATTCAA CAGACCACCC 81421 AGGGTAAAGG CAGCTTTCTC ACTTACTAAT CAGAATTGTT GGTTTTAATT CATTTTGGAT 81481 TTTAAGATTT CTTACTTTCT TGTCAGCTCA GAAATTTATT TAAGATGATT TTTATCTTTT 81541 ATTCAATACT TTAGCTTGGA GAACCATTCA GAGTTTCTAA CTCATTGTAT TGCCAAAAAT 81601 AGAAAACAGC ATGGTTTCTT TTGAAAATGT CTAACTTTAA AGTTACTTGT GTGTGTCACT 81661 CAGATTCACA TAGCTTTTTT GCCTAGTAAT GTAGTATCAT GTGGCAAGGC TATAAAAATG 81721 TTTACAATCT TTTATTTAAT ATGACTCTTG AGAGTTTATT CTAAGGAAAT AATTGAATAG 81781 TAACAAAACA CTATTAACAC AAAGCATAGC AATTTGATTT GGGCAACCAA ACACTGGAAA 81841 CAACCTAAAT GTCCATTACA GGAATCATTT ATGAAGCAAA CACTAAAATA TTTATTGTGA 81901 AGATTATGAG AACATAGAAG ACAGTTATGA GAGTAAATTT GAAAACCTGA ACACAAAACT 81961 TACATATACT CCAATTGTAA CTTATAAAAA ATACGTGCAT ATAAGGATAA AACAGTACAA 82021 ACAAAAAAAT AGTTGCGTTA GATTGGTAGA ATTATGGCTC CTTTTGCTGT CTTAATTTTT 82081 TCCTTTTACA TTTTGATACA TTATTTTAAT TTTAATTTTA AAATTCAAAA GAATTTGCCA 82141 CTCATCTTTG CCACTTCAAG GAAAAAAGAA ATGTGTTCGA TTATTCTGTT CTTAGTATAG 82201 TTTTGGCAAT TTCCTCACGT GTAAAAAGAG AATACTATTA ATAATTTCAG TATCTATAAG 82261 ACAATATAAA ATTAAAGAAT CTAGCCCAGT AACTGGTACA TGGAACGTAA TTAATAAATC 82321 ATTATGGACT TTTTTTCTCA CACCCAAGTA GGGAGGAATC AGTGGTCCCC TAGAGGCCCA 82381 GTGTAGAGGT GGCAGCACCA ATCCCTAGGG GAGAAGATCT TGGTGATGAT AATTCCTGAG 82441 CAGACAGTTA GCTGAGAATT CAAGAGCAGA AAAGTAAGAA AGAAACAACT TCTTGCTAAC 82501 ACCTTTCCAC CCACGTTTC-C CTGTTCTGTT GTACTCTGCT TACCCTTTCA TGGATGGAGG 82561 CAGAGGAAAG AGAACCAAGT TTGCTCTTAG TCATTCACTA TGTTGTTTAA TCTGCCTTCC WO 00/09525 PCT/US99/17712 EPI-109 632 82621 ATCTTTCTTA TCAGTTCAAA TTAGAATGTA GACCTGAATT TAAATC uu TTCTGTCAGT 82681 TATAATGTGA CCCTAGACAA AACACATTCT CTGAACCTCA GAGAACATTC TTCATTTCTA 82741 GAATGGGAAG ATTAATCTAT ATTCCACTTG GATGGCAAGT CTTTTATAAA CTTTATAACC 82801 TAAACATGTG TCAGTTGCTA GTATCATTAT GTTGGTAAAG TTATTCTGAG ATATGATAAC 82861 AGAACTGTTT TGTCTAACTC CACTAGCATG GTTCAGGTTT AGAGAGTGTG GAATTAAAAG 82921 GCTTTATCCT CAAATATGAC TTAAATCCGA TTTTTCTCAT CCACTTTCCT CCACAAACAA 82981 ATCCTCAGGA AATGACAAAC TTTACATGGT TAAACATCAG TTTTGTTTAG TCTTTGACAT 83041 CCACATGGTT AAATCATACA TTTGAAAACT GCTTATATTT GTGTTGTCTA TGTCTAAATT 83101 GAAAAGACTT ATTGAGGAAT AGAAGACTAC ACATTTTTCA GCAAACACTG CACGTTTTGC 83161 AGAATTTCCC CAGGCACCAG TCTCCAGGAA TTTATTGGCT ACTAACAATA CTAAGATATG 83221 GATGAATGAG GAAATCAAAA TGGAGATCTT GCAAGTTTTG TGAGAATGGG TGAATGGTCC 83281 AAATGAAGAG ATAAGTTGTG AAATATTAGT ACAAGTAAAA ATTATTTACA ATGAAAGACA 83341 TTTTGTCAAT AGCTATGAGA ATTTTACCAT TGACCCAGAA ATTCCATTTC TTTCTTCAGA 83401 AATACCCACG TAGGTATACA TATAAAAAGT TATTCATTAC AGTATCGTTT TTCATAGGAA 83461 AAAGTTTTAA AAATCAGAAG CTATCTAAAC TATGGTATAT CTAGGTCATA GAAATCAAAT 83521 GACTAAAAAT GTTAATATAA GCATATGTTT TTAAATTAAC TTGGCTTGGG TCTTCAGCAA 83581 AATTGGCTTC TTAACATTGC ACTCCAGAGT TAGACTTACC CACTCAGTCA CTTATCATGC 83641 AGGAGCAGAC TCCTAATACC ACATATCATA GAGCAGAGTA GGACACAGGT TCTCTGCAGG 83701 CAGGCAAATC CCAAAGAGAA GGGAGGAAAG GGCTGAGACA CTGCATGGTC AATTTCTTCT 83761 GAACTCTGCA ATGTACGGAG GTGGACAGTG TCCACAAAGA TTGCTCCCCT GGACCCACCA 83821 TCATAATAAC ACAACGGCTT TGTTTTGTTT TTGTTTTTGT TTTTTGACAC GGAGTTTTGC 83881 TCTTGTTGTC CAGGCTGGAG TGCAATGGTG TGATCTCGAC TCACCACAAC CTCCACTTCC 83941 TGGGTTCAAG TGATTCTCCT GCCTCAGCCT CCTGAGTGGA TGGGATTACA GGCATGCACC 84001 ACCATGCCCA GCTAATTTTG TATTTTTAGT AGAGACGAGG TTTCTCCACG TTGGCCAGGC 84061 TGGTCTCAAA CTCTTAACCT CAGGTGATCC ACCCGTCTTG GCCTCCCAAA GTGCTGCGAT 84121 TACAGGTGTG AGCCACCGCG CCCAGCCCAC AATGGCCTTT TGTTTACATC TCTAGTGCAG 84181 CACTCATTTC ATGTTCTTTC AAGAAGAATA CATATTTCAT CTTTTTATTT TATACAGCAA 84241 TTAGCACAGT CCCTGGCATA AGGAAAATGA TCATTAAAAG CTGGGTGAAA AACCTAATAA 84301 AGCTACTGAG GATAGGAACT GCAGACCAGC ATGGAAAGAA AACTATGAGC CAGATATTGA 84361 CATCATCCTG AAAGGCAGAA GATTTAGTAT AGGCAAGAAG TATGCTTTTG GAATATAGAA 84421 AATCTGGATT ATGATAAGAA AAGAATCATA TTTGTCTTAT CTTACCTACT CACTTCTCAG 84481 TTCCACATGT TTCTGAGGCT GTTTGTCCTT ACTTTCTTTT CTGTTTTATC CACTCTTTCT 84541 GTTCTTTAGA TTGGATCATT CCTATTGAGC TGACATCAAG TTAACTGACC TTTTATTTTG 84601 TCCAAACTGC TGTTAAATGC ATCCAGTGAA TTTTTAACTT TATATAGTAT ATCTTTTAGT 84661 CCTAGAATTT CCACATGAGT TTTTTAAGTT TCCATTTCTC TGCTGAGATC TCCTATTTGT 84721 TCATTCATTA TGACCATATT TTTCTCTACA TTATTGAGCA TAATTATAAC AGCTCTTCTA 84781 AAATTCTTGT CTGCACATTC TAACACCTGA ATTATTCTGG GGTCAGTCTC TGTTACATTG 84841 CCTTATTACA AAAACAGTAT AAGTCACATT GCCTTGTTTC TTAATATGCA AAATGATTTT 84901 TGATTGCAGA CTAGACATTT TGAATTAAAC ATTATAGAGA TTCTGGATTC TCGAGAGAGT 84961 ATTGACTTGT TTTTTCCATC AGGCAGGTAA CTTGACTGGA CTCAAACTCC AAACTCTAGG 85021 TCCTCTGTAA TGGGCAACTG CAGTAATCTT TGTTTAGTTC TTTAAGACTT ATTGGCCAGG 85081 CACGGGGGCT CATGCCTGCA ATCCCAGCAC TGTGGGAGGC CAAGGTGGGA GGATCACCTG 85141 AGGTCAGGAG TTCGAGACCA GCCTGGCCCA CATGGTGAAA CCCTGCCTCT ACTAAAAATA 85201 CAAAAATTAG CCGGGTGTGG TGGTGGGCGC CTGTAGTCCC AGCTACTCAG AAGGCTAAGG 85261 CAGAAGAATC ACTTGAACCT GGAAGGCAGA GGTTGCAGTG AGCCGAGATT GTGCCACTAT 85321 ACTCCAGCCT GGGTGACAAA AGCGAGACTC CCTCTCAAAA AAAAATTTAT TGGCACTGCT 85381 TGGCATCTGC TATGAATACA TGAAGTTCAT GGGTCAGCTA TAGATCTGGG CACGTTATAC 85441 ACAGAATTTG GGTCTCCCTT TCTCTGGATT TCTCCTTTTC TGGATTTCTT TTCTCATTTT 85501 CCAGCAGCTG TGGTTGCCCT AAACTCGGTC CTCTGTTTCT TTACGGCAGT AAGATTTGGG 85561 AACTTTTAGG TTTTACCTGC CTCTCAGACA AAATAAAAAA TAATT-TCAT CTTGATGCTA 85621 CTCCTTTCTT CCAGATGTAG ACACCTCTCT AATTTCCAGT TGCTTTTTAT TGCTCTCCAG 85681 AGTCTAAAGA TTATCATTGT TTTCTGTGGG AGAGTTGGTC TGATAAAAAC TACTCCCCCA 85741 AAACTGGAAG CTGGAAGCTT GTAATTATGA ATAGACTTTG AGTAGTATTC TTCTTTGGAA 85801 AAGGATTTTA ACTACTCCCT ATGTACTTCT TTATTTCCTG TTTTTCTCAT CCGTAATCTT 85861 TTTATTTTCA TACTTCCTAA GTCAGACAAT TTTCCTACTT GAAGATTCAG TGACTGCTAT 85921 CAAATGACCC CCATATTACT AAATACAATA TCCCCAACTG CATTTATAAA AAGAAAATTT 85981 ACTGTTTATT AGTAAACAAT GTTGTAGAAT AGTAAAATAT TGCTGGGCTT TGGAGCCAGA 86041 TAATCAAGGT TAGAATCCCA GATTCTAACT TACTAGCTGG TGTATTAGTC CTTTCTCATG 86101 CTGCTAATAA AGACATACCC CAGACTGGGA GACTGGGTAA TTTATGAAGA AAAGAGGTTT 86161 AATTGACTCA CAGTTCAGCA TGGCTGGGGA GGCCTTAGGA AACTTACAGT CATGGTGGCA 86221 GCAAGGAGAA GTTCCAAGCA AAGAGGGAAA AGCCCCTTAT AAAACCATCT GATCTTATGA 86281 GAACTCACTC ACTATCACGA GAACAGCATG AGGGTAACTG CCCTCACGTT TAATTACCTT 86341 CCACCAGTTC CCCCCCATGA CACATGGGGA TTATGAAAGC TATAATTCAA GATGAGATTT 86401 GGGTGGAGAA ATAGCCAAAC CATATAATTC CACCCCTGGC CCCTCTCAPA TCTCATGTCC 86461 TCACATTTCA AAACTCAATC ATGCCCTCCC AACTGTCCCC CAAGGTCTTA ACTCATTCCA 86521 GCATTAAGTC AAAAATCCAA GTTCAAAGTC TCATCTGAGA CAAGGCAAGT CCCTTCTGCC 86581 TATGAGCCTA TAAAATCAAA AGCATGTTAG TTACTTCCTA GATACAGTGG GGGTACAGGC 86641 GTTGGGTAAA TACACTGATT CCAAATGGGA GAAATTGCCA AAACAAAAGA GTTACAGACC 86701 CCATGCAAGT CCAAAACCCA ATAGGGCAGT CATTAACATT AAAGTTCCAA AATGATCTCC 86761 TTTGACTTCA TGTCTCACAT CCAGGTCACA CTGATGCAAG AGGTGGGCTT CCAATGGCCT 86821 TGGGCAGCTC TGCCCCTGTG GCTTTGCAGG GTATAGCCTG CTTCCTGTTT GCTTTTTCAC 86881 AGGCTGACAT TGAGTGTCTG TGGCTTTTCC ATGAGTATGG TGCAAGCTGT TGGTGGATTT 86941 ACCATTCTGG GGTCTGGGCC AGGTGCAGTG GCTCATGCCT GTAATCCCAG CACTTTGGGA 87001 GGCTGAGGTG GGGGATCACA AGGTCAGGAG ATCGAGACCA TCCTGGCTAA CACGGTAAAA 87061 CCCAGTCTCT GCTTAAAAAA TACAAAAAAT TAGCCAGGCG TGGTGGTGGG TGCCTGTAGT WO 00/09525 PCT/US99/17712 EPI-109 633 87121 CCCAGATACT TGGGAGGCTG AGGCAGGAGA ATGGCGTGAA C ut AGUTTGCA 87181 GCGAGCTGAG ATTGTGCCAC TGCACTCCAG CCTGGGCGAC AGAGCAAGAC TCCATCAAAA 87241 AAAAAAACAA AAAAACCATT CTGGGGTCTG GAGAATGGTA GCCCTTACAG CACCACCAGG 87301 CAGTCCCCA GTGGGGACTC TGTGTGGGGG CTCTGACCCC ACATTTCCCT TCTGCACGGC 87361 CCTAGTAGAG GTTCTCCATG AGGGTTCTAC CCCTGCAGCA AACTTCTGCC TCGACATCCA 87421 GGCATTTCCA TACATCCTCG GAAATCTAAG CCGCGGAGGT TCCCAAACTT CAATTCTTGA 87481 CTCCTGTGCA CCCACAGGCT CAATACCACA TGTAAGCCAC CAATGCTTGG TCAGGGCTTG 87541 AACCCTCTGA AGCAATGGCC TGAGCTGTAC GTTGACACCT TTTAGCCTAG ACATCTAGGA 87601 CACAGGGCAC CATGACCCGA AGCTTCATAA AGTGGGAGGG CCTTGGGACT AGCTGAGGAA 87661 ACCATTTTTC CATCCTAGGC CTCCAGGCCT GTGATGGGAA GGGCAGCCAT GAAGGTGCCT 87721 GACATGCCCT GGAGACGTTT TCCCCATTGT CTTGGTAACT AACATTCAGC TCCGTGTGCA 87781 GCACCAACTT ACTTATGCAA ATTTCTGTCA CTGGTTTGAA TTTCTCCCCA GAAAACAGGA 87841 TTTTTCTTTT CTATTGCATC ATCATGCTGC AAATTTTCAA ACTTTTATGC TATGCTTCCT 87901 GTTGAAGACT TTGCGGCTTA GAAATTTCTT CCCCCAGATA CCCAAAATTA TCTCTCTCAA 87961 GTTCAAAGTT CCACAGATAt CTAGGGGACA AAATGTTGCC AGTCTCTTTG CATAGCAAGA 88021 GTGACCTTTA CTCCAGTTCC CAACAAGTTT CTCATCTCCA TATGAGACCA TCTCAGCTTG 88081 GACTTAGTTG TCCATGTTAC TATCAACATT TTGGTCAAAG CCATTCAACA AGTCTCTATG 88141 AAGTTTCAAA CTTCCCCATG TTTTCCTGTC TTCTAATAGC CCTCCAAATT TTTCCAACCT 88201 CTGTCTGTTA CCCAGTTCTA AAGTCACTTC TACATTTTTG GGTATCTTTA CAGCAGTGGC 88261 ACTCCCCATG GTACTAATTT ACTGTATTAG TCTGTTCTCA TGCTGCTAAT AAAGACTTAC 88321 TCGAGACTGG CTAATTTATA AAGAACAGAG GTTCAACTGG CTCACAGTTC AGCATGGCTG 88381 GGAGGCCTCA GGAAACTTAC AAACATGGTG GCAGCAAAGA GAAGTTCCAA CCAAAGAGGG 88441 AAAAGCCCCT TATAAAACCA TCAGATCTTG TGAGAATTCA CTATCATGAA AATAGCATGA 88501 GGGTAACTGC CCCCATGATT AATTTACCTC CCACAGGGTC CCTCCCATGA CAGGTGGGGA 88561 TTATGGGAAC TACAATTCAA GATGAGATTT GGGTGGGGAC ACAGCCATAC CATGCCAGCT 88621 AGAGAGCCTT AAGAAAGTCA CCTAATCTCC ACAAATAAAA GGTTTCCTAT TTGTTCAACA 88681 AAAATAATGA CACCCCTTTT ATGGGATTTC TGTGAGGACA AATGATAACT AACATAGCCT 88741 TGCATAGTGT CTGGCACAAA ATAGCTACTC AAAAAATAAT AGAAACAACA TTTAAAAAAT 88801 GTAGACTTTA TTTTTTAGAG TTTTATGTAC AAAGCAAAAT TGAGCAGAAT GTACAGAGAG 88861 TTTCCGTATA GCACTCCCTA CCCCCAAGCA CAGATAGCCT CCCCCAGTAT CAGCATCCCG 88921 CACCAGAGTG GTACATTTAT TATAACTGAT GAATCTATAT TGACGTGTCA TTTTCATCCA 88981 AAATCCATAG TTTATATTAG GGATGCCTCT TGGTGTTGTA CCTTCTATGG GTTTTGACAA 89041 ATGTATAATG ACATGTATTC ACCATTACAG TATCATAAAG AATAGTTTCA CTGTCCTAAA 89101 AATCTTTGAT CTTCTTCCTA TTCATCACTC CCTCCCCATT AATCCCTGAC AACTACTGCT 89161 AATTTTCCTG TCTCCATTGT TTTGTCTTTT CCTGAATGTC ATATAGTTTA AATATACAGT 89221 ATGTAGGATT TTCAAACTGG TTTATTTCAC TTAGTAATAT GCATTTGATG TTCTTCCATA 89281 TCTTTTCAAA GCTTCATAGT TCAATATTTA TAGAATTGAA TAATATTCCA TTGTCTGGAT 89341 GTACTACAGT TTATGTATTC ATTCACCTAT CAAAGAACAC CTTGGTTGCT TCCAAGTTTC 89401 AACAATCATG AGTAAAGCTG CTATAAACAT CTATGTACAT GTTTTTTTGT GAATTGAACA 89461 TTTTCAGCTT TTTTAGCTCC ATTCCTAGGA GTGCAATTGC TGGATTGTAT GATAAGGGTA 89521 TGTTTAGTGT TGTAAGAAAC TGCCACGCTC TTCCTAACTG GATGTACTGT TTTGCATTCT 89581 CACCAGCAAT GAAAGAGTTC CTGTTGCTCC ACATACTCAC CAGCATTTGG TGTCGTCAAT 89641 GTTTTGAGCA ATAGCATTTT GATCTAACTT TTCCTAGGTA TTCTTTTTGA AGGAAATAAT 89701 ATGACAGATA ATAGAGAAAG GATATACGAG GACAGTTCTG TCCTTTATTT ATAGTCCATC 89761 ATTTAATGAA GGACTCTGTC CACACTTGGT ATTTTTAACT CTGATCCTCC TCTCCCATGA 89821 ACTCTGACAA TCTCCTAAAT CCCTGTTGCT GGCACACATG GTTGTGTATC AGGCCCCCTG 89881 TGGTCTGTCT GAAGCATGGC TTTTTTTTTT TTTTTTTTTT TTTTTTTGAG ACGGAGTCTC 89941 GCTCTGTCGC CCAGGCTGGA GTGCAGTGGC GCGATCTCGG CTCACTGCAA GCTCCGCCTC 90001 CCGGGTTCAC GCCATTCTCC TGCCTCAGCC TCCCGAGTAG CTGGGACTAC AGGCGCCCGC 90061 CACCACGCCT GGCTAATTTT TTGTATTTTT AGTAGAGGCG GGGTTTCACT GTGTTAGCCA 90121 GGATGGTCTC GATCTCCTGA CCTTGTGATC CGCCCGCCTC TGCCTCCCAA AGTGCTGGGA 90181 TTACAGGCGT GAGCCACCGC GCCCGGCCTT TTTTTTTTTT TTTTTTTTTT TTTGAGATGG 90241 AGTCTGTCAC TCTGTCACCC AGGCTGGTGC AGTGATGCAA TCTTGGCTCA CTACAACCTC 90301 CATCTTTCAG GTTCAAGTGA TTCTGCCACC TCAGCCTCCC AAGTACCTGG GATTACAGGT 90361 GCCCGCCACC ACACCCAGCT ATTTTTTTGT ATTTTTAGTA GAGACGTAGT TTCACCATGT 90421 TGGCCAGGCT GGTCTCATTC CTGACCTTGA GTGATCCACC TGCCTTGGCC TCCCAAAGTG 90481 CTGGGATTAC AGGCATGGT CATCACATGT GGCCTGAAGC ATGACTGTTG CTTTAATCAT 90541 ATGAAATACT GCTCTGTATT GTTATCTATT TGAAATGCCA CACCTCCTGA GCTAAATTGC 90601 AAGCTTTTAT GGAGCACAAA CCATATTTAT ATATATTAGC ATGATACCAT GACACATATC 90661 AAAAGCTGTT ATATATTGTT ACGTGAATTG ATTCTTTCTC AGTTAAGAGG ACCTCTGTAG 90721 TAGCACTTTC ATACCGTTAA TTTTTCATTT TGTGCCCAGC CCCTACTCTG TGAAAAATGA 90781 AATGAATCCT GTTATCATTT CCCTCCCAGG CCTTTTCTCC TTGTGGACAA TGTGTGGCTC 90841 AAGAGAAAAT TCAGTCAGTA AATTTGTTCA GTGCACAAAC TCTTTATCAC CTCTCACTGT 90901 TCTCAAGTGA GATAGAACAG AACATCCATC CAGTGTCTTA CAAATTGTCT GGTATATAGT 90961 AGGCACTCAA TAAATGTTTT TTGAATAAAT GCATACATGA ATCCTATTCC TATATATAGT 91021 ATGGTAGACA GATCATTGAT ACCCAAAGAT GCCCAAATGC TGATCCCCAG AACTTGTGAA 91081 TATGTTACAT TTCATGTCAA AAGGGACTTT GCTAATGTGA TTAAGGATTC AGACCCTTGG 91141 ATTGTAAGAT TATCCCGGAT TAACCAGGGC CAATCTAATC ACATGAGACC TTAAAAAAC 91201 AGAAAACATT TCCCAGCTG GTTAGAGAGA GATGAGACAG AGTAAAAAG AAAGAGATTC 91261 AGGGCATGAA AATGACTCTA CCCACTGTTG CTGGCTTTGA AGATAGAGGA ACTAGGCCAC 91321 AAAACAAGGA GTATGAGTGG CCTTAAGAAA TAGGAAAAAG CCCTCATCTG ACAGCCAGCT 91381 AGAAAGCAGT CCTCTGACCA CAAGAAATTG GATTCTGCCA ACCACTCAAA TGAGCAAGGA 91441 AATGGATTCT CCCCTAGAAC CTCCAGAAAG GAACACAGCT CTGTAATGCC TTGATTTTAG 91501 CCAGGTGAGA CCTGTTTCAG ACTTTTGACC TATGGAAATA TAAGATAATA AAGTTTTATT 91561 GTATGCTGCT AAATTTGCGG TAGTTTATTA CTGAAGCAAT GGAAAGCCAA TACAGACAGA WO 00/09525 PCT/US99/17712 LPI-109 634 91621 ATATACAGAG AGAAAGISAA TGAGTTCTTT CCTGATAATT TGTAt- . CA 91681 CTGGACAAGC TTCACAGAGG ATTCACTGGT TCCCTAGCAA ACCAGCATCT CCAGTCCTC 91741 AGCCTCCCTT TCTTAGGCCC AGCATATGTC AGCTGTGTGC ATAGAAAAAT CAAAGCAGGA 91801 CCCTGAGTAG TTGGAAAGAA AAGATGGTTG GAAATGGGTT GCACTTCAAG TGAGGAAACA 91861 AGAGGTAGGA GACCGGCATC TCTTTCTCAT ATCTCCCAGG CTGACTCTTC TGAGTTGTTT 91921 TCCCTTGGAG GCTATCOATG ACAGTCACAG TAACCTGATG GAACCTGGAT CATGATGAAA 91981 GAAGTAAGTG TCAATGGCTC CGACTTCCAA GGACTCTGAT GTCCCACAGC ACTAGCTAAA 92041 CAAAGCCAGT TGGAAA:-AG CTTAAATGGG GAATTTCCTG AATATATTCC CTATTGTTAG 92101 GAAGCCAGGT TGGCTTCTT GCCTACAATT ATGCCAAGCA GTCACACTAT AGAGTCCCTA 92161 GGGACATGAT ATTAAGTGAT TCTTTTAACA CAAACAACTT AATAATCATT TATACTAATA 92221 GCAAAACGGC CAACGGC:GA TATTCCACTT GAAGTAGAAT TGGCTATCCA ACTGGAAGAG 92281 AAGACAGGAA GACGTGATCT CCAGGGAGCC ACTAAAAGGA TTGGCACCTG CCTCTGGATT 92341 CCCCTTTTCC TTATATTACC TCTCAGCACT GGCAGGCCTT TATTTCAGGA TACAGTTTCA 92401 CAAGTATTAT GTCACGTCTC TGAGAATTAT GTTGGTAGAT ATTTCCTCCT CTGGCCAGAA 92461 AGACCTAGTT TGGAGTCTGG AGTCATGAAG GTGACATACA TGTAGCTAGT GACATAAGTG 92521 TAGCTAGTAA AAATAGTGAG TAATGGCCCT GAAATTCTAT TGAATGCCCA AAGTGCTGAC 92581 CAGGAACAAG CATGCTCAG CTTATCTCAC AAGGAACTTG ACAATTTTCT TCAAAAATCC 92641 TAGTAGCTAA GATTTCTTAG TAACAAAGCC ACTAAGGCAC AATTATGATT AACTTGACCC 92701 TTAGGTGACT TTTAAGGACT ATTCTATAAA ATATTACAAC TAATAGTGGA TCCAAGCCAG 92761 CACACTCTGC TATATAAGAT TAATTGACAG TGTCCACACT GGTAAAATAA GTTGTTTCAT 92821 AAATACATTA GAATTCATTT GCACTTTCTA CACAGCCCCA AGTCCAGAAC TTTCCCCAGA 92881 ATAGGTCTAT GTTTTGCAAT CTGCTACTCC ATACAGAGAT TTGAGTTCAC TTGGCAATTT 92941 AGTGCTGCTT ATATGTGACC AGTTAGTCTG TTTTACTTAT CTATGCCTTA AACATTACTA 93001 TACTTACTAA CTCCAAGATG CCTGGTCTCA ACTTGACAAA AATACCCCAA GTTGGGAAAT 93061 CCTTATGTGA ATATGTAGAT AGTCACAATT GCTGGTTGAT CATGATCTGT CTTTTCCTGT 93121 ATTTGAGAAA ATGGAGATAA AATGGACCAA TCCAAATAAT GGATTAAACA TGGGAATAGG 93181 TGAGAGAGAG AGAGGAATAC ATGGTGGCTC TCAGTGTCTG GCTTAGGCAG TAAACACTTT 93241 CGTTAATAAA GACGGAAAAT AAAAAAGGAA TAATTGGTGT CTAGGGGAAA ATAATGAGCT 93301 CAAGTTTTAA CACTCTGAGT TCCCGGATGT GAGACATCCA GGCGCATTTA TCCAAGAGGC 93361 AGTTGGAAGC AACGTTCCGG AGCTTAGGAG AGAGGCATGA CCAAAAGCTG GTGGGACTGT 93421 GAAAAGGTAT GGCCATTCTG GAAAACTGTT TGGCAGTTTC TTAGAAAATT AAACATGTAC 93481 TAACAACCCA GCAATTGTAC TCTTGAGCAT TTGTCCCAGA TAAATGAAAA AAAAAAAAAG 93541 CATTTTTTTT ACACAAAAAC ATATACATGA AAGTTCATAG AAGTGTTATT CATAAAAAAC 93601 TGGAAAAAAC TGAGATGTCT TTATTGAGTG AATGCTTAGG CAAACGGTGG TCTATCCATA 93661 CAATGGAATT ATGCTTAGCA ATAAAGAGAA AAGAACTATT GATACATGCA ATAACACAGA 93721 TGAATCTCAA AGGAATTAAT GCTGAGTGGG AAAAAAAGCA CATCTCAAAA TGGTATATAC 93781 TGTACTATTT TATTTACTTA ACATTTTAAA AATAGCAAAA TCATAGAGAT GGAGAACAGA 93841 TTAATGGGTA CTGTGTTTTG GGATGGGGAG TGAGAAAAGG GTAAGGTGTA AATATAAAGG 93901 GGTAGCACAA AAGAGCCTTG TGGTTGAAGG ATTCTATGTC TTGGTTGTAG TCGTGATTGC 93961 AGGAATCTAC ATGTGATAAA ATTGTATGGG TCTACATACG CATACACACA AGAGCATATA 94021 AAACTGGTGA CATGTGAAGA AGCTCCGCAC ATTGTGCCAA CATCAGTATC CTAGTTTCAA 94081 TATCAGACTA CAGTTATACA AAACATTGTC ATTGAGGGAA ACTGGGTAAA GGGAACACAG 94141 GACATTTGGC ATATATTTTT GCAATTTCCT GTGAATCCGT AATTATTTAA AAATAACAGA 94201 TATACTACAT ATCAAAAATT TAATGTCATA AAGTTGATGA GTTTACCTAG TGGATAGCTT 94261 TGTTAATATC TGCTATAAGA CTACTGAAAA TGACAGTTAT GCAAGTATAA GCTCAGAGAA 94321 CTTTCCTCCC CCTTCGTAAA TGAAATGAGC AAAAGAAATG AAACAGGAAA GGCAAGCAGT 94381 ACTGAAAACA GGGAAGGGCT CTTCCCCATA TAACTATATC TGCGACTTCA ACAGCTATTC 94441 ATCCAGAAAC ACAGCCTCTT GCGCTAAGAG GAAACTTTGG ATAACAATAT GTTTTCACTC 94501 TCCAAGAGAG AAAATGGATA GATTAATTTT TAAGAAAAAA AAAAAAACCT CACCAATTTC 94561 ATGCTGTGGC TTGCACCTTT AATCCCAGCT ACCTACAAGG CTGAGGTGAG AGGCTTACTT 94621 GAGCCCAGGA GTTCAAGGCT GCAATGAGCT ATGATTGATT GTGCTATCGC ACTCCAACCT 94681 GGAGTACTAA GCTAAGAGCT AAGAACACAG CTGAGAGCGG AGAAGAAACA AACAAATCTG 94741 ACCAATAACC CCCACTCCCC TCATTTTACT GGAGTGAGCT GAGACTGCTG GCAAACATGG 94801 CCTTTGACCT AGCCTGAACT GTAGCAAAAG TCATCAGATA TTTTTCCACC AATCAACAGA 94861 CAGAAGTGGG GAGAAAACAA TCGTAGTTCA TAACTACAAC AAGCAGATAA ACGAAGGCCA 94921 TGGTGAGGGA TGGAAGACAT TGTGATATAT CAAAGGCAGG CTCATTTAAA ACTCAACCCA 94981 AATTCCAAAC AAAATATATA ATTGAATATG TATTAATGCC AAAGGAGCTT GAGTGAGCTT 95041 TAGCACAAAC CCCGCCCTCC AGCCCCCACC CAAAAAAATC ACTCTGTTCT CTCCCCATTC 95101 TTTGATAGGC ATACTTGCTG TTTTCTCACA GCCAAGGTAC AGAGGGGACT TAGAGGAACT 95161 AGAACTCTAA TACACTGCTA GCAGGAATGT AAAATGAAGC ATCTACTTCA GAAAACCATT 95221 TTATCAGTTT CTAGAAAGTT AAACATAGAC CCACCATGCA GCCCAGCCAC TCTACTCCTA 95281 AGTATTTACA CAAGAGAAAT GAAAACGTGT CCCCACACAG TTGTATTTAA AGGTGATGGT 95341 TAGCCTTGTG TGTCAACTTG GCTAGGCTAT AATACCCAGT TACTGAATCA AATAGTAATC 95401 TAGGTGCATC TGTGAAGGTA TTTTGTAGAT GTGGTTAACA GCTACAATCT CTTGACTTCA 95461 AGTAAAGGAG ATTGCTCTTG ATAGTATGGG TGGGCTTCAT CCAATCAATT GAAGGCCTTA 95521 AGAGCAAAAA GTAAGGTTTC CCGGAGAGAA AGAAATTCTG CCTCAAGACT GCAGCCTCAA 95581 CTCCTGCCTG AGTTTCCAGT CAGCCAGCCA GCCTAAAGAT TTGCTAGGCA TTATAATCAC 95641 ATCAGCTAAT TTCTTAAAAT AAACCTCTTT ATATATATTG ATACAATGAA TGGTTATAGC 95701 AGCCTTATTT GTAATAGCCA CAAACTGGAA ACAACCTAAA TGTCCTTCAA TAAGTGAATA 95761 CATAAACAAA TTGTGGTATA TCCACAATTT TTACGCAGCA GTAAAAAGGA ATAAATGGTT 95821 GAATAAGGAA TAAACACATA ACAAGGATGA ACCTTAAAAC CCTAAGGCTG AATGGAAAAA 95881 GTCAGACAAA ACTAATACAT ACTGAATAAT TCCATTTATA TTGAAGTTCT AGAAAATGAG 95941 GACTAACCTA TAGTAACAAA AAGCAGAAAA ATTTTGCCCA CTGGTGATGG AGGGGGCGCA 96001 GGTATTGTAG AGTATCTGAG AAAGGACAAC TGGATAAAAG GGGGCACAAG AAAACTTTTG 96061 AGGGTGATTG ATATGTTCAT TATCTTGTGG CATGGTTTCA TAGGTGCATA CATATGTCAA WO 00/09525 PCTIUS99/17712 EPI-109 635 96121 AACATCAAGT TATACAC:TT TAAAATGTTC ACTTTACTGT ATATCTh1TA TACTTCAGTA 96181 GAGAGGAACC AAGAAAGTGG GCAGGGTGGG GGAGAGGAAA GGAAACGAGG GAGGAAAGGC 96241 CCTAATAGGA AGGATTTTGG AGTTTAGATT TTAAAATGAT AAAGGATGTT TGACACTCTA 96301 GGCATATGAC GAATATAGGA TTATGAGTCC ACAAAAACCA CCAGGAAGTC ATGTATGTTT 96361 ATACTTTTAA GTGAAGGATC AGTGCATTAT CAACTCCCTA ATGCTTTGCC TCTCTATGAC 96421 TGGCTGCTGT CCTTCTCATC CCAATACTCC TTCCAAAGCC CCTTGCTTAA ATGTAAGCCT 96481 TCTTTCCTCC TTTCAACACA TCCTGCATTC CGTGACAAAA TAAGTTTTCC TTAAACAGAA 96541 TGTACAGCAT ATTATTTGTA CAATTAAAAA TTTTTGGCCA GGTGTGATGA CTCATGCCTG 96601 TAATCCCACC AATTTGGGAG GCCGAGATGT GTGGATTACC TGAGGTCAGG ACTTCGAGAC 96661 CAGCCTGGCC AACATGGTGA AACCCTGTCT CTACTAAAAA TACAAAAATT AGCTGAGTGT 96721 AGTGTGGCAG GTACCTGTAA TCCCAGCTAC TCAGGAAGCT GAGGCAGGAG AATCGCTTGA 96781 ACCTGGGAGG TGGAGGTTGC TGTGAGCAGA GATCAGACTA TTGCATTCTA GGCTAGGAGA 96841 CAGAGTGAGA CTCGGTCCCC AAAAAAAAAC ACATTTTTTT TTAATGTTTC CTCCTTGCCT 96901 GTAGGAAAAA GGCTCT-ACT CCTTAGCCTG GGCATCAGAG CTCTATCTAA ATGGACTTTA 96961 ACCTGATTTT GTGGCACTAA TTCCATTGCA GTACTTGTCC GCTCACTGGC CTGTGCCTCT 97021 CTGCCACTAT TTTTGGAATA ATGTCCTCTC TCCATCTTGT TTACTCAACT ATATCCAACC 97081 TCTAAGGCTG TGCTCCTACA AAGCCTCCCC TGGCTACTTC AGCCCACAGA GATATTTAAC 97141 TGCTCTGCAG TTCAGGACAT TCTTCTGACT CTTTAAATCA CATTTACTTA TATATGATCT 97201 TGTGATATTT TTTGTTGACG TGTTTACTTT AATTTTCTTC CATAACCTAT TCATTCAACA 97261 AACTCAACAA TTATTTATTA AATGCCAAGT TAGAAAAATA TTATTGATTT TATATAGATT 97321 ATAGATATGT TTGAPATTTT ATTTGGCAAT CTGCAAGTAG AAAAATAATT ATAATGTGGT 97381 ATATCTGTGA TAGAAGTATT AGTGCAGAGA CCATGGGGAA CATAATCCAG CCTGGAAGTT 97441 CAGGAGAGAT ACGTGGAAGA AAGGACGTCA GAGCCTTTTT CCTACAGGCA TGGAAGAAAC 97501 ATTAAAAAAA ATTTTTTTTT TTGAGATGGA GTCTCACTCT GTCTCCCAGC CTAGACTGTG 97561 GTGGTGCGAT CTCTGCTCAC TGCAACCTCT GTCTCCCGGG TTCAAGTGAT TCTCCTGCCT 97621 CAGCTTCCCA AGTAGCTGGG ATTACAGGTA CCTGCCACAC ATGGATGATA AATATGATCA 97681 TATTTTCTTG TTCTTTTCCT CCTCAGTTGT CTTCCCTGAA GAAAGGAATG CCTTTTATAG 97741 ATGACAAACT CCCATTCTCA AGAACAAGGA TTTTTGACCA ATTTAATTTA ATCAGATGTC 97801 TGGCTTTGAC CTAGAAACAC AGTCACGAAA CTTGGTGATT AGAGACCAAT TCCCAAACAT 97861 GAGCATTTCT TAGGAAACAC AGTAAAGATC TGAGAGACCC AAGAGCAGAA GGGCGAGAAA 97921 CCAAAAGCCA TCAGTTTGCA TAGGAAACAC CTTGTTTAGC CTAATCTTTT TATTTTTATT 97981 ACTCTATTAG TCACTACAAC TATTTTCTGA TTGCTATGGT GATAGATGGT TTAAAACAAG 98041 CCTTCATTAA GAATTGTCAC ACCATGGTCT CAGTCAAAAA CACCAACATT TTTATTGGTA 98101 TTGACAATTA TGGGAATATC CAATTCCAAG AAGACAAGGA GACCTCTGAA CTTTCTAAAT 98161 GAAGACTCCA ATCTTCCTGA TCTGATGGGA AGCAGCTTGG CAAGATTACC AACCACCACC 98221 ACAGAGAGTG GACTCTAAGC TAAGACTTAA AAGATAAGTA GAAATTATCC AGGTAAAGAT 98281 GTGTACAGAG AAGGAAGTAC ATCCAGGGGA AAAGAACAAT ACGTGCAAAA GTACGGAAAT 98341 GGTAAAAAGT AATACTACAT AGTCAAAGCC AAGCAGAGTT CAGAAGGGAT CTGGTGGTGA 98401 AAAATACGGC TAGAGAAAGC AGCAAGGATT GGCTTCTAAA ACCTATGTAG TATCTTGGAC 98461 CTTACCCTAA ATGTAATGAG AAGCTTCTAA AGAATCTTTC ATTTATTCAT TCATTGAACA 98521 AATATTTTGA GGCTTTCTGT GAAGAACATC ATTCTAAGTA GTAAAGATAC AGCAGTGAAT 98581 AGGACACATA AAATCCTAGA TCTCACAGAA TTGACATTCC AGAGAGGGAA AGGTAGACAA 98641 TAAATACATA AACAAATCAT TTAACAAGAT GATTTCAGAC AATGGTACGT ACTGTGAAAA 98701 AAATGAAACA AGGTAATGGA CAGCGAAAAG GCACTGGAAG GAAGCCTGCT TACCTTTGCA 98761 TGGTTAGAAA AGATCTCTCT AAGAAAGAGA CCACATGTGA GCTGCGACCT GAAGGATACC 98821 GAGAAGCTAG GTGTGCAAAG ATGTGGGGAC AGAACTTTTG GACTGAATAG CAAATACAAA 98881 TGCCCTTGGG TGCAAGCTTT GCCTGTTCAA GGACCAAAAA GAAGGCCAGT GTGCCTGCAG 98941 CATACTAAGC ACAGAGGAAA ACACTGTTAT ATGCTGAGAT TGGAATTATA AGTAGAGCCA 99001 GATAATATAG TCTCTTATAG GTCATAATAA GGCAACCAGA TTTTATTCCA AGAGGATTTA 99061 AAAATCACTG GAGGTTTTGC ACTAGGGTGA GAGGTGTGAT TTGTATTTTT AAAAGATAAT 99121 TCTGGAGAAT TAACTATAAT GAGGTAGGAG TAAACTAAGT TAGGGGCTAT TTCAGTGGCT 99181 CAGACAAGAG ATAATGGTAG CTTAGACTAG GATAGTAGTC GTAGAAATAA ATAAAAGTGG 99241 CACTCTACTT TGGGGGTAGA GTCTATAATA GGTTTGGTTT ATGGATCATA TATGAGAGTA 99301 AAAAAAAGAA AATAAATTAA TAATGGTTCC TAGGTTTGTA CCTGAGCAAC TGAATAAATG 99361 GGTGCTGTGA ATTGAGATAA AGGAGATTGA GAATCACAGG CTTTGTTTTG CAAATTAATT 99421 TTGAGAGGCT TATTAGACAT CCCAGTGGAG ATTTCAGGTG AGTGGAGCCC ATTGAAAGGT 99481 AAGGGACAGG GTCAGGTGTG GTAGGTCAGG CCTGTGATCC CAGGACTTTG GAAGGCCAAG 99541 GCAGACAGAT CAGTTGAGCT CAGGAGTTTG AGACCAGCCT GGGCAACATG GGAAAACCCT 99601 GTCTCTACAA AATATGCAAA ATATTACCTG GGCATGGTGG CATATGACTG TGGTCCAAGC 99661 CACTTGGGGG GCTGAGATGG GAGGATCACT TGAGTACAGG AGGCGGAGGT TGCAGTGAGC 99721 CAAGATCTCG CCACTGCAAA CCAGCTTAGG TGACAGAGTG AGAACCTGTC TCAATAAATA 99781 AATAAGAAAC GTAAGGGAAA AGGAAATTAA TCTGATCATT GGCAAATGCA TAGTATTTAA 99841 AGCCAGGGGA GTAGATGAGA TACTCAAAGT AGGTGAAGAT AAGGAGGCAA TGAAGGCCTA 99901 GGACTCTGGT GTACATTTAG ATGGTTATAA GAGGAATAGA AACTGGCAAA ATAAGTAACA 99961 CTGAGCACCC AATGAGGTGG AGAGGAAAGC CAGGAGATGA AGCATCATAG AAGGCAAGAG 100021 AAGAAGGGTG TCAAAGAGGC GAGGCAGTCA TCAACTTCTG GGCAGTCAAA TAATATAAGG 100081 ACAGAAAAGT GACCATTGGA TTTGGAAATA TGATGAGCAC TTTGAGTGGA GTGTTGAGAC 100141 AGAAGACCAA TTAGAGTAGA TTGAGGAGAT AACGAGAAAT GAGAAAATGT AACCTGCAAG 100201 CACAGACAAT TCTTGAGAGA CTTTTCTGTG AAAGGAAACA GACACAGACT CTTAGCATGT 100261 CTTGTCTTTC TATGGGAAAT GTAAATAGTT TGAGATCAGG GATAGTATTT TATTCTGCTT 100321 TTTGTACCTC TACATTACCT AGCATAGAGC TAGCTAATGT GCACTTAAGT ATGTTCTCAA 100381 TTCTTATCGC CTGAATGACT GGATGGGTGA AAGAATGGAT GGATGGATGG ATGGATGGAT 100441 GGAAGGATGG ATGGATGGAT GGAAGACTTC TGATTTGCCA AGAAGAGGAT ACTGGTAGCA 100501 GAAATAAAAA CAGCACTGGA GAAAGAAGAG TTTAGATTTT TATTCTTTGG TGTCAGTTAG 100561 ACAGGAAAGT AAGACATTAG AAGAGTCCTT AGATAATTTA TGTAATTGTT CACTTAGGAT WO 00/09525 PCT/US99/17712 EPI-109 636 100621 TTTTAAATGT GATCACTGAT ATTGGACATG TTCCTAGTGA AGCATTTTTG GTGTTTCACT 100681 GGTTGAAGTT AATAACTGTA AAATTATTTC CCGTTCAGGA CAGAAAAACA GAAAACTTGA 100741 AGCTCCTATT AGAAAGTTCA AGATTCTCTG GGGTTCTTAG GATTTACTGT TCCCAAAACT 100801 CTGTCAAGAA CAAGAAAATG ACCTGTATAC TTAACTGGTC TAGGCAACAG TGGAAAGACA 100861 ATTCTCAGAG AAGATTTGTT TTAAGAAGAC ACTTTCCATA GGAATCAAAC AATAGCTTTC 100921 AGTGACTAAC ATGGTAAGAC ACAGGGTGTT AGCTCTTTCC TTCCAACCTC ATGGCTGTTG 100981 TACCTTACCT TTCGACCCCG TGTTCCTGAA ATTGTTAAAT TCATAAACTT ACCAAGGACT 101041 AACCAGCCTC TGGGGAATTG CTGTATACTT AGCAAACTTA CAATGGACAT ATTTATAAGC 101101 CATAATGATA ACTGACTAAT AGGAAATACC CTCAACTGAA AATGAGAGAT CATCATTTGC 101161 AAATGAGTTC CCTTGCCCAG GCAACTACTG GGGAAAATGT CATGCAAGCA AAATTAATCT 101221 TTGAAATCCT CCTTTTCCAT TTTTTGTGTC TTCCTTTTCC ATAGGCACCA GAAATATCAT 101281 GGTGCCTGGA TCTCATCTCT ACAGAAAAAA AAAGTGATTT GATAAACTGA TTTATATTGT 101341 GTCCAAATGT GATTGTATTT TCAAAGATAA CCTAAGGGGA GAATGCTGTC TGGCCCAACA 101401 GCAGGCTCTC GACTTCATTT CAGACACTGT GGCCAATGGC TGGGAAACAG GTATGAACAG 101461 TAGGTTTCTG AGTCCCCTGG AATTATTCCA TTTATGTAGC CACCTCCATG ACAGGAAGCC 101521 TCCCTACTCT TACTTCCCAG TTTGTTCATT CATGGCACCA GGTTGCAGAT TAAAATTTGC 101581 TCAGTGACCT TTTATCTAAT AATGTGTTAC CTTCTTCTCT TAAAAAGTAC AAGGGACAAA 101641 TGCTCATGGT ATACTTTTAG GAGATTGTGG CTCTCTATTA ACAGTATTTA TTCAACAAAC 101701 ATTTATTGAG CATTTATATG TGCATCATGC TAGGGACTGG AACCTAGTAA GTGTAGCACA 101761 TATTATTTCA TTTAATCCTC ACAACAAACC CATGAGGTTG GTTTTATGAT CCCAATTTTT 101821 CAGAAGAAGA AACTGATATT CAGAACCAGT TAACTAACTG GTTCAAGGTC ATGCAATTTC 101881 TAAGATACAG AACCAAGAGT CAAAGACATG ATTTTAAACC AAAGCTTTTT CTGCTACTCC 101941 ACATTGCTTC CCTAGGTGAG ATCTGAGGCA TTCCGCGAAA AGAGAAGGGT CATAAAGCCA 102001 AGGGAAGACA AGCTTAGGAA AAAAAAGGGA AATGTCCTAA ATAAACAGCT TTCCTATTTA 102061 CCAGAAACCA CTAGTTTAAA AATATAATGG GAAAAATCCT ATTCACTTTA ACAATGTTAA 102121 AAAAAAAAAA GATAGAAGAA ACATAGGGAT AAACTTAACA CATTTGTAGG ATATGTAAAG 102181 AAACTAAAAG ATGTTAATAA TGGCCTAAAG AAAAAAAAAC TTACATGTAT GGGGAGATAG 102241 ACCATCTTAC TGGATTCTAA TATTTAATAG TCTAGGTGTT CCATTTCTCA CCAAATTAAT 102301 GTATACATTT AATACAATGT CAAACGAAAT ATCTTAGGAA TTGCTTACAA ATTGTCAGAT 102361 AATTACAAAG TTTACCTGGG AAATATAAGC ATATATGAAG AGTGAATGGG ACCCCACCAC 102421 TCCCCCCAAA ACAAAAAAGG TCTGAAAAGG ACAGAAATCA AGGAGAGTCT TGCCTGCCAG 102481 ATACAAAATT CTATTATAAA GGTGTATTGA TGAAAACAAT TTAATACTAG TGTAGCAATA 102541 GGCAGCAAAG CAATGAAACA GCATAAAAAG ACCAGAACTA TACCTAATTA TGATGAAGAT 102601 TTAAGGTATG ATAAACATGA CATAATTCAA ATCAGCAGAA ATTGGCATAG ATAGGGTTAA 102661 GACAAATAGC TAATCATTAG AGGGGAGGAA GGAAAGGAGG GAGGATAAAA TTAGGTTCCT 102721 GCCTTCATCT TACATTAAAA TAAATTCCAG ATGTATTACA TTTAAATTTT TTTAAAAAAA 102781 GAAACCACAA AATACTTGAA GAAAATATAA GTTGTTATAT AGTCTTTTGA TGGGAATTTT 102841 TTTTTTTTTC AGAGACAGGG TCTTGCTCTG TCACCTAGCC TAGAGTGCAA TGGCATGATC 102901 ATGGCTCACT GCAGCCTTGA ACTCCTGGGC TCAAGTGATC CTCCCAGCTC AGCCCCCCAG 102961 GTAGCAGGAA CTACAGGCAT GCGACACCCC ATCCAACTTA TTTTTTATTT TTTGTAGAGA 103021 CAGGGGTCTT GCTTTGTTTC CCAGGCTTAT CTCGAACTTC TGCCTTCAAG CACCTCAGCC 103081 TCCCAAAGAG CTGGGCTGAT GGGACATTTT TTAACATAGT GCCACATTAC CATAAATGAA 103141 AAGCTTGTAA AATACTAATT TTTAAAACTA ATATATATCA GAAATTTTTA TAAACAAAGT 103201 TAAAAAGCAA ACACAAAAAA TTTGTAGCAC TTATGACAAA TATATGTATA TATATGAATA 103261 CAAAAAGAGC CTTTACAAAA CAGTAAGAAA ACAATGAATA CTCCCAATGG AGTATTCAAA 103321 ACTAAACTGC TAAAAGCAAT TCAAAACAAA AAACATAAAC TATGCATATA TGTATGTGAA 103381 AAAGTTTAAC CTTATCAAAG AAGTAAACTC TCAAAGAAAT AAACATCAAA TAAGGAAATA 103441 GCCTTTTCCC ACAAATAACC AAAATCTGTA AGAATACTGA GCTGCGAATG TTTCAGAAAA 103501 AAAAAAAAAT CATACACCTA GTTCGGCATG TAATTAATAT AGATCAGAAC ACTTTAAAAA 103561 TATTTATAGG CCAGGCACGG TGGCTCATGC CTATAATCCC AGCACTTTGG GAGGCCAAGG 103621 CGGGTGGATC ACCTGAAGTC AGGAGTTTGA GACCATCCTG ACCAACATGG TGAAACCCTG 103681 TCTCTACTAA AAATACAAAA ACTAGCCAGG CATGTTGGCG TATGCTGGTA ATCCTGGCTA 103741 CTCGGGAGGC TGAGGCAGGA GAATTGCTTG AACCCAGGAG GTGGAGGTTG CAGTGAGCTG 103801 ACATTGTGCC ACTGTACTCC AGCCTGGGCA ACAAGAGCAA AACTCTGTCT CAAAAAATAA 103861 TAATAAATAA AAATAAAATA TTTATATACT CTGACCCATC AATTTGTCCA GCATAATTAG 103921 GCATGTGTAC AAGGGTTTAC ACACAAGAAT GCCTATTGCA ATATTGCTTT TAATGCTAAA 103981 AAAAATTGGG GAAAATGCTT TAAAAATATA GATTAAGACT GTACATTGTG GTACAGTCAT 104041 ATAATCAATA GTATACAGCT ATTATTTATT TTCAGCCACT GTCCAAAATA TAGCCTGGCC 104101 TAACAACATT CTGTTAGGAT ACGCAAGCAC CGTGAGGAGA TCAGCTATAA AGTATCAGTG 104161 TTTCACACCA CTGCTCCTTT GCTAATAACC TTCAATGGCT TTTAAAGAAG TAAAAAACAA 104221 AGGCAAAATT CCTTAGTCAG CCCTTAAGAC TCTCTGTTAC TTAGCTCAAA CTACCCTTTT 104281 CAACAACACT GCCCTAACCA GGATGAGTTT TTTGCCCCCC TGGAGTACAT TCAGCCTTTC 104341 CTTATCAAAC CTTCCTTTAA ATAAGTATCT TCTCCAGGAC CACTTCACTT TCTTCCCCAA 104401 TTTAGCATTT TCTATATCTC CAGGCCTACC TCTATAAAGC CTGTCCTAAC CACTCAAACC 104461 CTAGCTTTTT CTCTGAACTG CTAGAAATAT TTTTCTCTCA TTGGCCATTT AGGTAAAAAG 104521 GTTTTTACTG TTTATTACCT ACTCAATAAA AATTTTCTTT TTTTGAGACA AGGTCTTACT 104581 CTGTCGCCTA GAATGGGGGG AAGTGGTGTG ATCACAACTC ACTGCAGCTT CTACCTCCCA 104641 GCTCAACAGT CCTCCCACCT CAGCCTAGTG AGTAGCTGTG ACTACAGGCA TGTGCCACCA 104701 TACCCCACTA CTTTTCATTT TTTATTTTTT GTGAGATGGA ATCTCACTAT GTTACCCAGG 104761 CTGGTCTGCT GATCTCAATT GATCCTCCCA CTGTGGCCTC CCAAAATGCT GGGATTACAG 104821 GCATGAGCCA CAATATCTGG CCCCAGTAAG CTTTTAAGGC CATTAACATG AGGAACAGTG 104881 TTCTTTACAC TATTTTATCA GCTAGGGCTT TGCATGGAGT AGGAGTTTAG TAAATGCGGT 104941 TGATGGGTTA ATCAATGTGT GAAAATATTC AGAGCCACCA AAAACAGATA TTATGTCTAT 105001 TCTCATCAAC AATCAAAATT GAGTAAACAG CCATTTTCTA ATACAGGAAA CCACAAAACA 105061 TTGAATGGTG ACATTAAAAA ATTCCCCCAG CAGGAGCCAA CCAATTTTTT CATCCTGATC WO 00/09525 PCTIUS99/17712 EPI-109 637 105121 CAAGTTAGCA AACTGCAAAA GATAGGAAGC ACTAATGAGT GGAAATTTGA GTAGAAGCAT 105181 TTCTTATGAA GGCTGTCTTG ACTGGATCAC ATTTTTATTG CTGTTGGAGG TGCCAAATGT 105241 GTGTGTTTAT GCTAATCCTC CACCTCAGGC AACACACAGT CAAGGATCCT ACCAAGTGTT 105301 ACCGTCAAGT GTCTGTTGGC AGCTCAAGGC CCCAGCGTTG TTCCCTTGCA CTAGGGAAAA 105361 GACATATTCC AGGTACAAGT ACTCCCACTT TGATGCTACA GAGGAGTTGC TGAACTTTGT 105421 GTCATTAATC TCTCTTCGTT AGATCCCAAC CCTGTTTAAA TCCCACTATC TGCCTACTCT 105481 GGGTCTTCAC CAATTTACTA GATCATAGTT GGAGAAAATC TACAAAGCCT TGCTCCCTTT 105541 AGATTTAAAC AGCTCTCCCT TTAAATTTAG AATTGCTAAC TTCAAGCGGG CCCTTATGCG 105601 ACAGTATGCC TGTCAGTCAT ACTACATTTC CTCAATTCCA TTCATGTGAC TGCTCCATAC 105661 CCTTCCCTCT CTCTTCATAC TACTATTATC TCTTCCCCCC TCCCTCATTT TTAACTGATG 105721 ATCTTGTTTC CTATTTCTCT GAGAAAATAG AAGCCATCAA AAGAGAGTTT CCACAAACTC 105781 CTACTGCCTT ATCTAGCCCT GTACCATATA CTTTGCATTT CCTCTCATTA CCATGGATGT 105841 ACTGCCTATC TGTGCTTCTA TCTAAGGCTA ACCCTTCCAC TTCAGTTTTG AATATTATCA 105901 GCTCTTACCA ACTCAAGGCC ATTGCTCTAG CAATTCTCTC ATTCTCTCTC ATTTTCTTCC 105961 ATCAAGTTTT CCTTTTCTTC AATTAACAGA GTAGCTCCTA AAGGGAAAAA AAAGTCTTCT 106021 TTTTCAATGC TCATCATCAC TGGCCATCAG AGAAATGCAA ATCAAAACCA CAATGAGATA 106081 TCATCTCACA CCAGTTAGAA TGGCAATCAT TAAAAAGTCA GGAAACAACA GGTGCTGGAG 106141 AGGATGTGGA GAAATAGGAA CACTTTTACA CTGTTGGTGG GACTGTAAAC TAGTTCAACC 106201 ATTGTGGAAG ACAGTGTGG.C GATTCCTCAG GGATCTAGAA TTAGAAATAC CATTTGACCC 106261 AGCCATCCCA TTACTGGGTA TATACCCAAA GGATTATAAA CAATGCTGCT ATAAAGACAC 106321 ATGCACACGT ATGTTTATTG TGGCACTACT CACAATAGCA AAGACTTGGA ACCAACCCAA 106381 ACGTCCAACA ATGATAGACT GGATTAAGAA AATGTGGCAC ATATACACCA TGGAATACTA 106441 TGCAGCCATA AAAAATGATG AGTTCATGTC CTTTGTAGGG ACATGGAGGA AGCTGGAAAC 106501 CATCACTCTC AGCAAACTAT CACAAGGACA AAAAACCAAA CACTGCATGT TCTCACTCAT 106561 AGGTGGGAAT TGAACAATGA GAACACTTGG ACACAGGAAG GGGAACATCA CCCACTGGGG 106621 CCTGTTGTGG GATGAGGGGA GTGCGAGGG ATAGCATTAG GAGATATACC TAATGTTAAA 106681 TGATGAGTTA ATGGGTGCAG CACACCAACA TAGCACATGT ATACATATGT AACAAACCTG 106741 CACGTTGTGC ACATGTACCC TAAAACTTAA AGTATAATAA AAAAATATAT ATATATATAT 106801 AAAACAACTA AAAATAAATC TTCTTTTTCT GCAGGATCAG TCCATCACCA CACACACAGG 106861 CTGTGTTTTA TGTTGTTCCC CAGCTTAAGA GATCGTTCTC CAGATCCCAC TGCTCCTTCC 106921 AGTTGTCACC TCAGTTCTCC ACTTCTTTTT GCTGATAAAC TACTCTAACT AGTTACATAT 106981 GATTTCTGTC CCCAGGTCCC CTCCCTCAGT TGTTTTGAAC ATAATCATTT ATATCATTTA 107041 TCATTTTCAC TCTAATTGCA CAACCAAAAA CTCCCTTTTT TTTTAGATGG AGTCTCACTC 107101 TGTCACCTAG GCTGGAGTGC AGTGGCATGA TCTCGGCTCA CTCCAACCTC CGCCTCACGG 107161 GTTCAAGTGA TCCCCCTGCC TTAGCCTCCT GAATAGCTGG GATTATACAC ATGCACCACC 107221 ACACCTGGCT AATTGCTTTG TTTTTGTTTG TGTGTGTGTG TGTTTTTTTT TTTTTTTGGA 107281 CAGAGTCTCA CTCTGTTGCC CAGGCTAGAC TGCAGTGGCA TGATCTCAGC TCACTGCAAC 107341 CTCCACCTCC TGGGTTCAAG CGATTCTCCT GCCTCAGCCT CCCGAGTAGC TGGGACTACA 107401 GGCATGCACC ACCATGCCAG GCTAATTTTT TTGTATTTTC AGTAGAGACC AGGTTTCACC 107461 ATGTTGGTCA GGCTGGTCTT GAACTCCTGA CCTCAAATGA TCTGCGCACC TGGACCTCCC 107521 AAAGTGCTGG GATTACAGAC TTGAGCTACT GCGCCGGGCT ATTTTGTGTT TTTAGTAAAG 107581 ACGGGGTTTC ACCATGTTGT CCAGGCTGGT CTCAAACTCC TGACCTCAAG TGATCCGCTC 107641 GCCTCAGGCC CTCAAAGTGC TGGGATTACA GGAGTGAGCC ACCATGCCTG GCCATAAAAC 107701 TGCCCTTTGT TAATATGACT GTTGGCCTGC ACATTGTCAA ATCCAGTGGC ATTCATCTTA 107761 CTCGGCCAAC CTACGGCATT TGACACTGTC TGTCTTTCCT TCTGTTCCTC TATCTGTTTC 107821 CAGTATACTG GCCTGGCTTT CTTTTTACCT CTTTTATATG CTCTTCCAGT CTCAGGCTCC 107881 TTTGGGGATT TGAAGGTATG TTGCATTTTG CTATTCAATG AATAATGACA AGTAATGATC 107941 ACTTAAGACA TTAAGTGGTC AGTTCCTTTA CTAGGATAAA AATAATTTTC TTCCCAACAT 108001 GGGGCATATT CCATTTCCAG TCTGACTGTT CTGTGTAATC TTTGTATTCC TTGGCAGCCC 108061 CTTTTATATC AGTTCATCTA CTGTGCAGGA AATTGGACAA ACATTTGCAC TGGTATAACC 108121 AAATACAGTT GAACTTTTGG CTTGACTCTT AGCTGAACTC ACCAAAAATA ATTTCTGTAA 108181 GAGACTGAGA CGTCTACGAG TAGGTTTTTC AGAATTAGTA AACATAAATC AAGGATACAC 108241 AGGTAGATTT GAATTTCAGA TAAACAACAA ATACTTTTTT AGTATGTCTA CTGAAATATT 108301 TGTATCTTAT CTGGCAATTC TACCTGGTAC AGAACTAATC CATTCTCTTG AAAGATCTTG 108361 ACTCTGTAAT AAGTTCTTTG GTGATGGAAG GGAGGTATTT CTGTAATTAG AGTCACTGTC 108421 TTCCTCCCAG TTTTTTATCC TGGCCCAGAT CTGCAATGAA CACACGACAG AATCCAGGGG 108481 GGATGAAGAT GGGTGCTTTG CAGGAAAAAA AAATTAAAAA CATCTGAAAA AGCTTTTGTA 108541 CTAAAAGAAT GTGATCTAAA AAAGAAAGCA GGAGAACTTT CTGTCTGCAC TTTACATCAG 108601 AACAACCTTC GCGTCTAGAA GCTGTGCCCT GTGGGAAGTG GTGGTGCTTG GTAAGAGATG 108661 CCAGGACCAG TGGTACCCAC TGGGAGCACT GCCAATACCC AGCAAGGAGC ATGGGTGCAC 108721 AGTAAGGCAT TGCACTGTGA TTCAGCATAA AATAACAATA AGGGAACGTC ACGGAGAAAA 108781 GGCCAGACTT CCTTTGTTTA GAATGTGGGA AATGTCTTCT GAAAAATGGT AGTAAAAAAG 108841 CATGCTTGGA TGGTCCACTC CAGGCAAAAC TGACTAATCG GGGGTCAGGG ATACAACCCC 108901 TGCATCATAT GTTTGTTTCT GTTGGGCTGA CATGAGGTTC ACTGTGACCA CTGTGTTTA 108961 ACCCCATAGT CTCCTGGAAA TACAGCCAGG TCAAGAGAGC TCCACATAAA ACATAATCAA 109021G AAAAATAAAC TCAAGTTTCC ACTGATCAGC TTTTCACAAC TCTTATCCTT TCACTAACTT 109081 TGGAGCAAGA TTTGAGAATT GGATGGCTAT TTTAGGGCTA TTTCTGCGCT TTAGTTCAAT 109141 GTTTTGTTCT TTCTTTATTA GAGAACTATG GTTTTTTATT ATATTTACAC TTTAAGTTCT 109201 AGGGTACATG TGCACAACGT GCAGATTTGT TACACAGGTA TAAATGTGCC ATGTTGGTTT 109261 GCTGCACCCA TCAACTCGTC ATTTACATTA GGTATTTCTC CTAATGCTAT CCCTCCCCCA 109321 GTCCCCCACC CCCCGACAGG CCCTGGTGTG TGATGTTCCC CTTCCTGTGT CCAAGTGTTC 109381 TGTTTATGTG ATAGATTACG TTTATTGATT TGTGTATGTT GAACCAGCCT TGCATCACAG 109441 TCACTTGCTT ACAAGAAACA AACACTTCAC AGATGGATCA TTATGTGTGA TAAGTGAAAT 109501 CCAAGGATTT ATGCTCAGAG GTGGGCTTAA CAGGTAGGAA GAGCAGTATT TTCCTTCAAC 109561 CATGAGTGTA TGCAGGTTTT TCTTTTCTTT TTTGAGATGG AGTCTCACTC TTTTACCCAG WO 00/09525 PCT/US99/17712 EPI-109 638 109621 GCTGGCGCGC AGTGGTSCGA TCTTGGCTCA CTGTAACCTC TGCCACCTGG GTTCAAGCAA 109681 TTCTCCTGCC TCACCCC AAGTGGCTGG GATTACAGGC ACCTGCCACT GTCTCCGGCT 109741 AATTTTTGTC TTTTTAGTAG AGATGGGGTT TCACCATCTT GGCCAGCCTT GTCTTGAACT 109801 CCTGACCTCA TGAATCATCC TTCTCAGCCT CCCAAAGTGC TGGGATTACA GGCATGAGCC 109861 ACTGCGCCCA GCCCACAGGT TTTTCAAAGA CTAAACTTAA AAAAAAAAAA AAAATTTCCC 109921 AATGAAATAT AAAACT;AG TGCTAAACTG TGATAGACTG TTTTACAAGA ATGCCAGTTT 109981 TCACAAGTGT CTATAGAACA TGTAATTTAG ATAGGTAAGA TGAAATTTTG ATAATATTTG 110041 ATGGCAAATT TAAACAGSTA TACAACAAAA ATAAAATTCT AAGCCCCTCA ACCAACTGAA 110101 TGGACTCCTT CTCTCAGCCA AAGGAATACC AAAGTAAACC TGAAAAACTA GTTTTGGCCA 110161 GGATTGGGGG TAGGTGGGGG AAGCCCAACA TGACTCATTA TTCTCTCCTC CCTTTGGAAT 110221 TCAGGCACAA CTGAATC-CA GCATTGACAC TAAAACACAG ATCTTAAGAC TGACAAGCCA 110281 GACTCTTTGT AGCAGAGAGC CAGGCCCTGG AAGAAATCAA GTTATTTTAT CCCAAAAAAT 110341 ATTTCTTTGA TATATT"TCA AATGGCCCTG CAAAGCTGTC TCTTGTGGGG AAAATTGACA 110401 TGCTGTACAG AATTTCCTTC TCTTTCCAAG TTTTTACTGA TCCAGGAGAG ATTTAACTAA 110461 GAGGCTAGCA TGTTTTTTTT TTTTTTTTTT TGAGGCGGAG TCTTGCTCTG TTGCCCAGGC 110521 TGGAGTGCAG TGGCGTCATC TCAGCTCACT GCAACCTTCG CCTCCCGGGT TCAAGCGATT 110581 CTCCTGCCTC AGCTTCCCGA GTAGCTGGGA TTACAGATCC ATGCCACTAT GCCCAGCTAA 110641 TTTTTGTATT TTTTGTAGAG ACAGGGTTTC ACCATGTTGG CCAGGCTAGT ATTGAACTCC 110701 TGACCTCGTG ATCCGCCCAC CTCGGCCTCC CAAAGTGCTG GCATTACAGG CGTGAGCCAC 110761 CGTGCCCAGC ACAAGACATT TACCGTCTAT TCTCTCTGAA GCTACTATCT AGAGGCTTCA 110821 TCAACATAAT AAGACCCTTG GTCTCCACAA CTCCTTATCT TATCCTATTA GTTTCTACTG 110881 ATTCCAGGTC TTTAGATAAT AACAACTCTT TCAACCAATT GCCAATCAGA AAGTCTTTGA 110941 ATCCACCTAT GACTTAAAAG CCCCACTCCT TCAAGTTATC CCGCCTTTCT GGACTGAACC 111001 AATGTACACC TTATATGTGT TGATGGATAT CTGCCTGTAA CTTCCATTCC CCTAAAATGT 111061 ATAACATCAA GCTGTAACCC AACCACCTTG GGCACATGTT TTCAGGAACT CATGAGACTC 111121 TGTTGCAGAC CTTGGTCACT CATATTTGGC TCACAGTAAA CTTCTTTAAA TATTGTATAG 111181 AGTTTGGCTT TTTTCATTGA CACAGGAAAA ATAAAGAATT GGAAGGTCTT TCATCAGTCA 111241 CTGAGCCAGC TTCATATCTG ACTGAGGTCA TACAGTTCAG TGATTTGTAG CTTTGCTACT 111301 TAGATTGCTA TCCATTATCT AGAAGCATCA GGATCACGTG GGACCTATTG GAAATGCAGA 111361 CTTTCCTCCT AGAACCCAGG ACCTTGGAAT ATTCTTGGCA CATAGTAGGT GCTCAATACA 111421 TATTGAACTC CTAGGTGCAA TTCATTAATT CATGAATTAA TGAATTAACA CGCTCTCAAA 111481 GTTTAGTGCT TTTTCACAGA CTAGTCTTTC TGCCTCTTAA GCACTCAGCT CACCACGCTT 111541 CCAGTCTCAC TCCCCTATTA GTCTGATTAA AATCTGCTTA CATGTGAGTC TGAGATCAAG 111601 TGTTATCTCT TCTGAGAAGT CTTCCCTCAC TGGCCCAAAG GAATTTCTCC TCTATTTTAG 111661 CACTGTCCCA GTTGACTTGT CATTATTCTA GTCTTTTTCA TATTAGTTGT TTTTCATATA 111721 TATGTTATTA AGGAAACTAG TCATTTCCCC TAATAGAACA AAATTGCTGG CCTTTGGGGT 111781 TGGCAATGGA GGGGAGGCTC TTCTTGAAAA GGGGGAAGAG TGTTCTCCTA ATATTTTTCT 111841 TACGAGATTT ATGTTGCTCA TCTTTAGCCT TTAGTCCCCC ATTGCCTGCC TACAGTTGGC 111901 AGAGACCATC TGTTCTCTCA CTGTCAGGAA CTGTCTCAAT TCTTGAAGTT CAGAGTCAAA 111961 AAAGAAGCAA GTTTTCCTAG CTCTTTGATC AACTTTCAAA GTTTTACTTC CATTTGAAAA 112021 TTTACTAAGT CACCAGGAGA TGGTTTATAC TGAGAAATAT CCACTCATAC TCTTCCTCTT 112081 CAACTTTCTT CCATATACAC CCTATTACAG GGATATAGTC TTACTCTATA GCTCAAAAGG 112141 ATGACCCTAT CAGAAACCTG CACAGTATGT AAAACATTCT CACCAGAGGT TCACTTGTGT 112201 ATTTCCACCC TAGAATGGAA GCTCTACAAA AGCACAGAAT GTATCATTTT AACTTTAGAT 112261 TCTATTTTCA CACCCAGTGC TTGACACATG ATTTGAAGTT AATATTTATT TATCAAGTGA 112321 TTGTTTTAAA ATCATGACTC ACTCAACAAA GTTATAAGAA TAAGAATAGT GTTACAGAAT 112381 TGGTATACAC AAGCTGACCA TAATCAACAC ACCTATTATC ATTTTTTTGC GACAGGTTCT 112441 CGCTGTCTCA CCCTGGCTGG AGTGGAGTGG CATGACCACG GTTCACTGCA GGTTTGAACT 112501 TCCAGGCTCA AGCAATCCTC CCACCTCAGC CTCCCACATA GCTGAGCCCA CAGGTGTGTG 112561 CCACCATGTC CAGCTAACTT TTTAATTCTT TGTAGAGACA GGGTCACCCT ATGTTGCCCA 112621 AGCTGGTCTT GAACTCCTTG GCTAGAGAGA TCCTCCCTCC AAGGTCCCCC AAAATGCTGG 112681 GATCTCAGGC AAGAGCCACC ATGCCTGGCC ATAATCAATA CACTTTTAAG AATGCTAGAA 112741 TGTTATATCA GATGCATACT TCAGCACTAT CTCAAGCAAA CTGGGGTGTG GGTTATTCTA 112801 CATATAAAGT TCAGCAGTGT TGTTCCACAG TCCCAAACTC CAACTGAGGT CAAATGTAGG 112861 GTGCAGCAAG GTCACTGGGG CTGTCATCAA GGGCCTCTCC TTGCACTCTT GCCAACCCTG 112921 TTTCTTGATT GTCTCTACCA CCATGAGTCA CCAGCAATCT CCCACAGTCA CTTGTTTAAA 112981 AGTTCACAAG TATTGTGTGA ATTGCAGGCA ACCCCTTGAC TCCCTGATTG CCTGGTCTTC 113041 TTCCTTGGGC TCTACCATTT TTTTTCCCCA GCACTCTTTC TGCTGCTCTA AATTTTAATT 113101 CATGCAATTC CATATGTGTT TCTCTATCAT TCTTCATCTC TTTCCTCTCC CTTCCATCCA 113161 ATTTTGTTTG TCTGTTTGCT TGCTTGCTTG CTTTAATACA TTTCTCTTTT TCTGAGAAGG 113221 CTTGAGTCCA AAACTCTCAG TTACCTGTTG TTCTGTTTCC CGTTAGTTAA TCTCCGAACC 113281 TTCATAAATT AAATCTGACA AAGTCCCCTG ACTAACAAAG GAAATGCACA AGTCACAGTA 113341 AAAGGGGCAC ACACAGAACA CAAATAGACC CAGGGTCTTT TCTGTTCATC ACTCAGCTTT 113401 TTATAGGAGA TCCAGGAGAA ATGAAGTGGA AAGGGAAGTG TGTTGAGTTA CTATACAACA 113461 CAAGAGTAAA CTTTCTTATA AGTGGTAATT TTTTTTTACA GGAATAATTG AAAATGGAAA 113521 TTACCTTCTC TACTCATAGT AAGTACTCAG TGCGTTCTTG ATGGGATGAG AATGTGTTTG 113581 AGCTTTAGTG TAAGGCAGAA TTCTGTTTAG TCTGCCAGTA TTGGAGAAAA ATAAAACACA 113641 AAGGGACTGA CATGTAGGAA GTGGCACCTG GGAGGGTCTC AATTCTTCCT ATTACAAAAA 113701 TGCCCCAGAG AAATAAAAAG CTTGTGTACA TGTTGAGATG GGAGAGTTCT CTGGCCCCCC 113761 TCGCAGGATG TGTGACAGTG GGGTGGCTCT CTGCTGCGCC ACCATGAGCT CAAACCCCTC 113821 ATAGGAGGGG GAGCACACAG GCAGGAAGGT GCAGGAGCTG GGCGAGCTCT TTGGGCTCTG 113881 GCCCCGTGGT ACTGTCTAGA GGTGGGTGCC TGCAACTCCT GAAAGCCCAA GTGGGCATGT 113941 GTTACAGTGC ACTCTTTCAG CTTTGCTGTC TGCAGCTTAA GCGTTAACCA GCTCAGTTTC 114001 TTCTTGGTAC CCAGGTCCTT GTCTGGCATC CAGGAAGAAT CAGGTTACAC ATGGACTTGA 114061 AGGATGAATG TGGGAGTTTT ATGGAGTGGT GGAGGTGGCT CTCAGTGGGA TGGATGGGGA WO 00/09525 PCT/US99/17712 EPI-109 639 114121 GCTGGAAGGG GGATGGAGTG GGAAGATGAT ATTCTCCTGG AGTTT( ,zu TCCAGCACC 114181 GATCTCCTCT CCAGTCGTCC CCAGCCTCTC GACGTTCAGA TGCTCCTCTT CTCTCCTTCT 114241 CTGCCATGCT GTTCTGCCGT TCATCTGCCT GTCTCTCTCT GGAGCCTGGA ATTTGGGGTT 114301 TATATGGTAC ACAATAAGGG GCATGGCAGG CCAAAAGGGA ACTTTTTAGG TGCAAAAAAC 114361 AGGAATGCCT CTTCTCACTT AGGGCTATAG ATTTTCAGGC TTGAAGGTGG GGCCTTTACC 114421 AGCGAACCTG TATTTCCCTG TCTCCTGTGC ATATCAATGT AATCAAATAC TGGGCTGATC 114481 CAGGATGTTT CTTTAGACCA ATTATGGGTA AAATAATTTA CATTCAGGTT TTTATATTTG 114541 CTTTTGTCAT TTCTTTTTAA GCAATCATGT AAAATATCTA TACGACAGTA ATAGATGATA 114601 GCGAACCTAA TTAAAATTAC CAGAAACTTA AGAATCTCTA ATGATTTCAA CTGTAACTAA 114661 GGTTATTTCT CTTTATGTTG AACAATGTTG GGAGATAAGA CACAAGAGTT TCTCAAGTAT 114721 TTCAGAAACA CAAAGAGGGA GGTTATATAA ATAATATTTT TTTCCTACTT TGGGAAAATG 114781 AAAGCTAGTC ACAAAGTTAA ACCAGTGGTT ATTTTAATAT TTAAAATACA GGCTTGGATG 114841 TATTTCCTGT TAAAGAAAAT AAAATGCAGA ATATTCAAAA CGTCTGACCA CCCTTCTAAG 114901 AAAATGCATC TCTGAGGTAT TTTTCCTTAG AAGTTATTGT AAAAATCCTG GAGAAGCTTG 114961 AACACAGCAA AGCAAACAGG ATGCAGAGTT TAATCTGTGG AAAGCTTAGG GAAGAAAAGC 115021 AAATCATTAA AAATAGGTCT TCCTCTGAAG ATTTTTAAAA CGCAAAGAGG GTGGAATAGC 115081 AATGATAATA AAAAAGCTGG CATAGAGAGT GGCACAATTT GCTGTGCCAC TGAGCTGACT 115141 GGATGTGTTC TGAATTTCTA GGCATTAGTG TACCTTTCCA CACGCATTCT CCCTTTAAAA 115201 AAAATGCCCA CACACTGAAT ACTTTTTTCA TGCAATTTAA AATAAGCGCA CCATCTAGTT 115261 TACAGAAATT CACTAGAAGT TATTTATCCT AAAATAGCAG AGATCTAGAA GAATTTTGAG 115321 CTCTAGGACA TTTTAGACAC ACAGAAAGAA GAATCTGGAC AAGTCTTGAC CAGACATGAC 115381 AGAATAGAAA TTTCTTTTCC TATTTATCTC TTTGAATAAA ATTTTCAGGA TCTTACAGTG 115441 GACAAGTTTG TTATCTACAC ATTGTGAAGC ACATTGATTT CTCCTCTGTA GCCTTAGGAA 115501 GATCTGAGAG GTGACTGAGC TGATTGAATG ATCCGTGACC GCTCTACTGG GACCAGTAGT 115561 AGAACTTTAC TGGTGGAGAC CTGCTGGAGG TTTGAGAGCA GACTTTGAAA ATTACTAGAG 115621 CTACACAGAT ACTGTGTGGC TAACTGGATT ATGTTTAGAG GCTTTCAGAA CTATGCTGCT 115681 GCTGCTGCAC TGTAGCCAGG ACGCACAGAG AACATCTAAG GCTCTTGAAT GGGGCGATAG 115741 GGACAGATTT CAGCAGCCAT CTGACTTCAG TGCTCATTTT GATGCTTTCC CTGCAGGGTG 115801 CAGTGTGCAG TGTGCAGTGT GCAGTGGTGG GAGGCTCACA CAGGAATACT TGCTTCTGTA 115861 GCCCTAATTT CCGGTTCAAA CTCTGCATTC ACCTTGACAG ATTCTTTCCT TGGCCAAAAT 115921 TTAGTTAGGC TTCTGGGCTT TCTCTTATGC CCACCTGCAG ACTTTTTGGT AAAATCCAGT 115981 TTTAGTAAAG AGCTCTGCTA AGTCAGTTTA GCAAGAATCC CCACCTCAAA AGTCACTATC 116041 TCCCTCCCTG GTAGTGTCTG GCTTGTCTTC AGCGAGAATT CTATTAGGTT CTGTTAGATT 116101 AGAATCCTCC TTACCCTTGA TGCTTCCTCT TAGTATTTTT TCATCCACTG ACTCCTTGAC 116161 CCACCTTGCT CCTCGGCTAT AAATTCCCAC TTGCCCATAC TCTGCAGTTA AGACTATTTT 116221 CTCCCCACTA CTGCAAAATC CCATTGCCAT GGTCCCTATA CTATCTCAAT GGTAATGAAT 116281 AAAGTCTGCC TTACCATGCT TTAACAAGTA ACATTGAACC ATTTTTTTCT TTAACAATCT 116341 GCTGCACAAT GAGATTACTA AAACTTTATT CCATTTTGCC ATGCTGGATG TCCTCAATGG 116401 AATGGCTCTT GTGAGCACCA AATCATTGTG AGAAGGAAAA CCCATCTCTT ACAGCCCCCT 116461 GTAACGTGAT GTATGTTACA TGTGATGTAT GTTACATAGT TTTTTTTCAT GTTGATCACT 116521 TTTTGCCCAT TTTCCTATAT CTTATCAGTT GGAAGACTGT GGAAGTTTGT AGTACTAAGC 116581 CACAAGATGA CTAAGAAGAG TTGAAAGGGC AAGTGGGGCT AAAAACAGAT TTTGTTTGAC 116641 TTACCCCACC ATTCCCCCTA TCATGGGGCT GAATCTGCCT GGAGGAAGGA GCATCTTTAT 116701 CTTTGTACTG TGAACCACAC AGTCTAGCAG CAGCACAGCC AAGGCACTTG GGGTTTCATG 116761 AGACTAAGTA CATGCAATTC TATTGTAAAG GCTTAAAATA TATACAACTG ACCCTTGAAC 116821 AACATGAATT TGAATTGCAT GGTCAGTTAT ACGCAGATTT TCTTCCACCT CTGCCACCCC 116881 TGAGACAGTA AGATCAATCA ATCCTCTTCC TCCTACTCCT CAGTCTACTC AAAGATACTT 116941 GAAGTCTACT TGAAGATGAC AAGCACAAAG ACATTTATGA TGATCCACTT CCACTTAGTG 117001 AATAGTAAAT ATGTTTTCTC TTCCTCCTAA TTTTTTAACA CTTTCTTCTC TCTAGCTTAA 117061 TTTATTGTTA AGAATACAAT CTATAATACA TATGACATAC AAAATATGTC TTAGTTGACT 117121 GTTTATGTTA TCTGTAAGGC TTCAGGTCAA GAGTATGCTA TTAGTGGTTA AGTTTTCGAG 117181 GAGTCAAAAG GTGTATGTGG ACTTTCAACT GCAGGGGGGT GGGCACCCCT GCCCCCATGT 117241 TGTTCAAGGG TCAACTTTAC TGCCAAAGGC AAGCCTTTAC ATCCACTTTT TCCATCCCAT 117301 CAGTAAATGG AAAAAGATAG CTACAGTATC CCTGCGTCAA ATCTTTTTTT TTGCAGATCA 117361 CAAATTGGCC ACTCACCTTG CTCTGTGAGG GGTAAAATGC CCCACTTTCT TTAGTAATAT 117421 TTAAGTTAGA TAATATTTAA GTTATAAAGT TGTTCTTTGT AATCGTTAAT TGTAATTTTT 117481 ACATAGTTTC TTTCAAACAG AAATAGCATT TTTGTTAGAT AACCTCCCGT ATAGATGATG 117541 AAACTCCTTT TAAGGGCTAT CTGAATTTTA ATTCCTTGAA AAGGCAGAAA TTGGATAGCT 117601 AGTAGTCATA AATGTACTGT GGCTTCCCCC AACCATCTGG GCTATATAGA AGCTGCATCC 117661 TTGGACTGCA GTAGAGGAGT CTTACAAAGC ACAGAGCAAC TTCTCTCCTG GGTTGCGCTA 117721 GTTATGATGG CAATTTTAAA TGTGTACTTT TACCCAAAGA AAATCCTTAT TATCAACAAT 117781 CACAATGCCA TCATAACCAT GGTATAAAAA ATTCAAAATG TCCCAGCTGA AGTGGAGGCA 117841 AAGACTCAAG TTCATGGAGT CAGAGTTTCC TTGCTATTCC TCTTTTTCAA ATGACCATTT 117901 AGTAAGCACC TGAAGAAAAT ACTATGGACG GCATTGAAAA GTGAAGATAG GTTTAATCTT 117961 CTCGAAAATC TAATTCTCCA GATGAAACGC TGACACTTAT CCACCCCACA GACCCTATAG 118021 CAGATGTGTC ACTGGCCATC ACATTTGACA CAGAGAAGTC ATAACTCAGT CAGCACAGAG 118081 ACATTTCCAT GAGTTTCTGA ACCATGGACA GAACGTCGTC TGTGGGACAT GAAAACTGGA 118141 ACTTAGAGGA CAGGCACATC TGAGAAATGG GCAGTTTAAA GGCAGAACAT AGCACATATG 118201 TGACTGGGTT TTAGAAGCAA ATTTACAAGA CGCACTCTTC TTCATCCTAA ATAATCTGCA 118261 ACCAAAGCTT CCAAAAAAGA CAATTTAGGA ATGCAGAGGT GAGGAGTAGG GAGGGGAATG 118321 GGATGAGAGA GAGTGGAGAT TAATGGTGGG CAGAGCGAGG TTTAGAACTT AGTGGTTTCT 118381 TCAGGTTCTG AACTGAAATT TGTATACTGT AAAGGCACAA ACACCATTTT TAACAAAAGT 118441 GAGCAGGACT TCCTATCTGG TTCAGAAAAT AGGTGAATAA ATAGTACGAA TTATTAAAAA 118501 TAATAATTTC CACTTATACA TAGGAAACTT GATAGGAACC ATGATAAATG CTTAACTCTT 118561 AATCTTCAAG GAACTCTGCT AGGGATATAA TATTATAAAT CTTGTTTTGC AGATGGAGAA WO 00/09525 PCT/US99/17712 EPI-109 640 118621 ATTGAATTT AACCCAAGTT ATCATAACCC TTAAATGATT AAATGATACT GTTACATGAG 118681 AAAGCTGCGT ATCTGTTTCC TGGATTTGTA GCCATAATTT GTGTCTCAAG TCCCTTTTGC 118741 TGCCAGCTAT CTTGGTAGG TGTGTTCCCT TTGGGCTGTT TGATACCCCC ACATTTATCT 118801 TTTTTTTTTC TCTTTTTTTG TTGAGAGAGT CTTTCCCTGT TGCCTAGGCT GGAGGGCAAT 118861 GGCGCGATCT CGGCTCACTG CAACCTCCGC CTCCTGGGTT CAAGTGCTTC TCACGATTCT 118921 CTTGTCCCAG CCTCTCTAAT AGCTCGGATT ACTGGCATGC ACCACCACGC CCACCTAATT 118981 TTGTATTTTT AGTAGACAAG GGGTTTCTCC ATGTTGGTCA GGGTGGTCTC AAACTCCTGA 119041 CCTCAGGTGA TCTCCCTGCC TTGGCCTCCC AAAGTGCTGG GATTACAGGT GTGAGCCACC 119101 ATGCCTGGCC CCAAATTTAT CTTTAATGCC CCAAATTATC TAGTTCCCAT GACTGGGCTT 119161 CTGCTTTGAT CCTTTCTGCA CTTGCTGGAC CCTCTCCCTG GGAAATGAGA TTGTGTCCTG 119221 AGCCCCTACT TAGAGGCTAT GTCTCTGCTG TTCCTGAATG GGCCTCCTGG ATGAGACCTC 119281 ATTAAAAGTC TAATTCTCTT GGAGAATTGA GAGATACCTA TTTGTCTCAA AATCATTGAA 119341 ACCAATTAAT GTATTATGAG CCTCTATCCA GTGATTTGTA CCTCAATTCC CCAATCCAGC 119401 TGTCAAGGCC AATTTGTTCT ACCTTACCTA GTAGGTAAGT CTGGAATTGT AGCTGTGGCA 119461 TTTTCAGTAA TGGTACTCTA GGTTAGCAGT CCCCAACCTT TTTGGCACCA GGGACCAGTT 119521 TTGTGGAAGA CAATTTTTCC ATGAAGGGCT GGGCAGGGGA GTGGTTTCAG GATGAAACTG 119581 TTCCACCTCA GATCATCAGG CATTAGATTC TCACAAGGAG TGCGCAAGCT AGATCCCTCA 119641 CACATGCAGT TCACAATAGG GTGTGCACTC CCATGAGAAT CTAACACCGC TGCTGATCTG 119701 ACAGGAGACA GAGCTCAGGC AGTAATACTC ATTTGCCTAC CGCTCACCTC CTGCCGTCCA 119761 GCTCAGTTCC TAACAGGCCA CGGACCAGTA CTGGTCCACG GCGCAGGCAT CAGGGACCCC 119821 TGTTGCTAGG TATAAGCATC TGGCTGCTGC ATGTCTTCTG TGTAGCTACA TCTGTATGTG 119881 TATCTGATGA GATATAAATT ATTTGATTAT AAATTACTTT CTTCATATTA GAGTTGTGAA 119941 TGAGTATCAC ATATAATTAT ACATAAACTA GGAATATGCT TTTTAATAAT GTATATAAGT 120001 AAGTTTCCTT AACTATGACT TTCATCTTAG CGTAGTAAGA CCGTGCTAAG AAATATTTGT 120061 GATGAAAATA CGCATTGGTA GAGTTGAGAC CACTGGGTGA TGAAAGAGTG TAAAGATTTT 120121 AAAGCCTTCA GATCCTGGTT CAAGGTGAGA AATGTGATTG GGAGCAAATC AATTAACTTC 120181 TTGAAGTCTT ATAGGGCAGT TATGAATACT TAATGTTAAC ATATGTAAAG CTCTTCTGCC 120241 CTGTATACAG TAAATGCTAG TTAGCTATTA TGATCACTAC TAAAATGGGG ATGACATAAA 120301 CCTCATAAGG TTTTAAGTAT TATGCAAGAT ACTATACAAA GTCCAGTAAA TATCACATTC 120361 AATTGAATCC ATGATGTCCG ATTATTTTAG CTACTTCCAA GAGAGAAAAA AATGCTGTCA 120421 GTTTTACTGT TCTTATAGAG AGCAAGGCAG ATCCCAATTC CCAATGTGGT AACGTGAAAA 120481 TTTTTGCATT TGAATCAACA AAACACTTTC TCCTTTCTTT CCTACTATTT AACAACTGGT 120541 AAGTCTATAC TCCCCCAAAT CTGGAATTCT CCTTTCTTAT TCTTTTTCCT CCTACCAAGA 120601 CCGCAGGATC TTTTACTTGG CTATAAGGGG TAAACCTCAA GTAGTACAAG TTCTCTGTAT 120661 TACTTTTATA CTCTGTCACA GATTCCCTTT GTTTCCTCAT CTCCATGTGA ATTTAGTTAA 120721 ATTCTCAGCA TTCTGATCCT TACTATACAA GGTAAATGAA TATAAAAACA AAACGAAACA 120781 AAAACCTCTT CCTATTTACA TAAGGCCCCA ACCTAATATT TAGTGATATA TATTAATGTG 120841 AACAAGGAAC TAACGAAGAC TGGGAAGAAA TTCACAGACT TGAGAGAAGA AATGGCAGGA 120901 TTTCCTGGGA ACAATTTCAT GTAACGTCAA AGGTGGTAAA AGGTCAAATA GAATGAAGAT 120961 GGAGAATACC GGATTTTCTT ACAAAATGAT TTCCCAGGAG ATCTCATCAA ATGCACGAGG 121021 ATACCTTCTC AGTTTCACCT AGTGAGTAAA AGACTGGTAA CATAGCTCAC TTACAATTTG 121081 GATAAACAAA ACTAAACAAA CAACATCAAA ATTTCAGAAA AAATAATAGC AAAACAGAAA 121141 TCAAACACTC AAATTTTTGG TCCTTCTGTT TATTTCATTT TGGATACTCA GTGAATGTTA 121201 ATTAACCAGG AAACTTAAAA GTTATTTCAA TTATGAACCT CTTCAATCCT TCATCAATTA 121261 TTTTGAGTAT TCTGGTCTTA AAAACATCTC TTTCTTCTAC AAACTTCTGA AAGAGATGAA 121321 CACCTCCACC TACACCAAAA TAATGTGCTT TGCTGGCCAA AAGTACACGT CCATTTTTAC 121381 TTAACAGTCT AAGGAAAGTC TGGTGCAAAT TACTATAATA ATCTGGGTTG TAAATGGTTT 121441 CTGAGGTGAG AATGAGATCA TATTTTACAA AAAGTTTTTC ACTACTTAGT ACAAGCTTAC 121501 AAAACTCAGA CCACTCACCA GAAAAAAATC GGCATTTATA TAGTTGTGTT ACTTTTGGTT 121561 TCCTGCATCT TTTCACATCT GGCTCATTTA CATCATTTTC TTCATCTTCC AAAGTGGAGT 121621 TAGCTACTAC ATTAGGTAAG GTTACTTCAT CAATCACCAT ACTGTTATAA TCTTGAAAGT 121681 GAATTTCTTT GGACCCTCCC TTGAATGCAG TTATACCTAG TAAACCTGAT CCACAACCAA 121741 GATCCAAGAC TTTTTTCCCA GCAAATTTCA CTTTGGCCTT TGTGAAATAA GCCAGGAGGT 121801 CAAAGGTACA TTCCCAGATT TTTAAGCCTC CCTCATAAAC ACCTGTAATC AGATCAGAGT 121861 GAGAAGAAAA GCTTTTTGAA ACTATGTTTT CTCCAGGGAA GTTCTCTTTC AACAAGATGG 121921 TTTTCACTAC TGATAACTTA ACATGCTGGA AACCTGGTAA TGTTTCTATG ACTTTATTTT 121981 CTAACATCTT CTTTAAATCT TTAGGCATAG CATGCTCTTT GGCAGCTCTC AAGGAGGGCT 122041 GTTTTCCATG TGGCTCCAAG TTCCTTGAAC TGCTGGCTGC ACTGAGTGGA CTGTCTGTGT 122101 CTTGAGAGGG AGCTGCATTT TCCATTGACT TATGTTCCCA CAAGTGATCC TGAGGCAAGT 122161 CAAATTGTTC TGCAGAACAT TTTCTGTCCC TCTCTTCTCC TTTTTGACTT TCTGAGACTG 122221 ACAGCTCTTT TGAGGAATCC AGGGTCAAAG CTCCATCTCT AATGGGTGTT AATTCATTTT 122281 CCAGATGGTC TTCTATAGTG AAATTAAACT CAAAGGTCAT CCTCTTATTA AATGCACACA 122341 ATCTTTAAAT TCAGATTCTT CAACTTCTGG ATAGAATTTG ATGATACACA CAAATCTGCC 122401 TCAATTATTC AATTAGTTTT GTTGGGCCCA ATTTCTCTTT AGCAGCTTAT ACATGGTAAC 122461 AAATATTTAG AGATATTTCC AAATGACTTT TTAGACGTCT TTGGTCCTCT TTCCAAGCAG 122521. CTCTGGAAAG AAAAAAAAAA AAAAAAGAAA GAAAATGATG ATTAAAGCAA AATGGCACAT 122581 TTCACTAAAG TGTAATATTA AACAGCCACC CCCACCCCTC CCTGTCCCAC CATACAGCTG 122641 CTTTTTCTTA AAAAGTTGTG GGGAAGAGAG AGAGATAAGA GATTTGGACA CTCATACACA 122701 CCTTAAGGGT TCCAAAGTGG GAGAAGAAAA TCAACTATAA AAACAAACAG AAGAACAACA 122761 GCAACCACCA CCACTACCAC CTGGACAAAC ATAAAGTCCA AGATATTCAG ACAGGACAGC 122821 CTAGCTACTT GCTGTCTTTC AGCTGTCTTG ATTTGTGTCC AACCATATTC ACCCCCTAAG 122881 CTTCCAGAAT AACTTCACTT CTGTCTTTTA CAGAAGAGGT GCAGTATTTT ATTTTGGTAA 122941 GTCAGCGTCC CTTTAAAAC ATGCATAGGT ATGGCCTGGT GTGTGTAAAT TCATCCAAGA 123001 CTTCACTCCA AACATTTAGT CGAGAACAGC AGCCCTAAGT GTATACAAGT GGGGGTAATT 123061 TGGCAATAAT TAGTAAAGAC TAATTCGGTG GCAGAGCAAA CGCAAACTAG GGCACTGCAG WO 00/09525 PCTIUS99/17712 EPI-109 641 123121 TACTTTGGAG AGACCT3TAG AAATAAGAAG CAACTTTATT GAGAATCTTC TATCTACTGC 123181 GCTAGACACT ATACCATCTG CCTCAATTTT CACAGTTCTG GCAAGTGGGA TCTTTGTTCC 123241 CTTTATACAA GATTTACAAT TTGGGGGAGA GGCGGGTCAC CCAGTCCCGC GGCTAGGAAC 123301 GCGCCTCTTT CCTCTCCCAT CACGCTGCAA GGCTTGGAGT CACTTCCGGC TGCAGGTCCC 123361 GGAACAAATC CGACCCCAGA AGTGGGGACT TCTGGCCCTC ACCTCCCCAT TTGAATGTAA 123421 TGTTTACAGT GATCCAGACC TGGGGATGCT TGCTTCCCGA CGTGTCCTGG GATCGCGCTT 123481 CTGAAAAAGC TCACCTCACA ACGCCTCCTC CGGACCTAAA TCGCGCACCA GTGAGTCGAG 123541 TCCTCCAGGG GCTAGAGAAG CCCGACTTTC TTTCCGGCCT TGAGGGACCC GGGCTCACCA 123601 AGAAACCAGC CGCCCTCCTC TCTATGGTTT TGGAGCCGGC GGAGAGCGCG CAAGGGTTGG 123661 CGGGACTGCG AGTTTCCGGT CTGGGCTTTG GCGGGTCTGG PTTGAAGCTC TCCTGTTTGA 123721 CGAAAGTATG TCTCAGGAAG GTGCGGTCCC AGCTACCCG GTTCCCCTGG AAGAATTAAG 123781 TAGCTGGCCA GAGGAGCTAT GCCGCCGGGA ACTGCCGTCC GTCCTGCCCC GACTCCTCAT 123841 ATCCTTCCTT GGTTGTCACT TCTACCTAGA GAAGGGTGTG GGCGGGTCGC GAACCTTTCT 123901 CTTCTGTCCC TTCAGACCCA CCGCCAGGCT GGGTTATATT ACCGCCGCCT GAACCCCCTC 123961 TTTTCTTTGT CAGTGAGTGG GATGAAAAGT GAGGGACTGG AGGGGAAGCG ACAACCGTGG 124021 TAGATTTAAG TAAGGCTTTG GCCCTGGAAA GCCTCGCGGA CGTGTTCTGA CCCAAGGTTT 124081 TAGCAGTGGA TGTGGCGTTT TCTTCCATTC CTTCTTTCAG TTTTTCTGTA CTCGTTGCTT 124141 GCAATTAAGT GTAAATACTT TTGCTAGTGG ATAATGGGGG AGGCAAGGAC TGAGACCTGC 124201 GGTATGACGA TAGCTCTGGC TCTTAATAGT TTGAGGTAAA GCGAGATACT CTGAGCTTTT 124261 GTCTCCCGTA AAAGGGTGG TGAATATGAA TAAGGGCTTT CTTAGCGTTA TAAGAATTAA 124321 AGGGCATAGT TCTGTGGTGT GAAATCTTTA AAAGATGTTC AGTAAATAAA AATGATTTTC 124381 CTCCTTCCCC TCTCAGACCT CTTTTTCTTC TTTCTTTCTT TTTTTTTGAC AAGTTCTCAC 124441 TCCTCTCACC CAGGCTGGAG TCTTTCTGAA AGAGTTCTTC CGCTTGTTGT TGGCTTTCAA 124501 CTGTTGGATT TGAGGCGCTT AGCGCCTTCT TCGTCCGGGT GCAGCACATT CTTGATTGGT 124561 CTCATGCCTT TGTGGTTGTA AATGTGCCTG GAATCCTAGC CTTTCATGGT AAACCATATG 124621 TATATGTATC TTTTTCACAA CATTTGAGCC CAGCTTTATA CAATTACACT CAAAAGAAAA 124681 AAAGTAACCT TCACTTGACA GAATCTCAAT ACTGCACAAA TATTGTGCAG CTAAAGCCCT 124741 ATGTAATCAC ATAGAAGTCA TTCACCTAGG CATTAGCAAA ATCTCAGAAG GTGCCAAAGC 124801 CCCCTTTTTT AGTTTTTGTG TAGGTACAGA ACTGCCGTCT TCAAGGAGTT TCAACTTGAA 124861 AACAAATAGC CACCCTCAAA ACATTCAAAA ACACTTAAAC TGCGTGCATA ATGTGTGTGA 124921 GACATGGTGT TAGGCTTTGG GAGAACAGAG ACACGGAACG TGATTCCTCT TCTTCCCCAC 124981 AAGCTTATAG AGAGACTTCA TTAAGTTGAA AGTCAACATT CCCACCTAGC TTTGCACTTC 125041 AAACGACATA TTCAAAAAAG CCCAAACTTC CTCTAGTTTT CTTCATCTGA GTAAATGGTT 125101 TCACAAACTG AAACCTTGAA TCCTCTCTGT CTCACACACC CGATCAGTAA GTTCTATTGT 125161 TTCTGATTCC AAACTATGTC TTGAATCAAT CCGTTTATCT CCATCCTCAT TGCTACCACT 125221 CTGATTCCAA ACCCTTATCA CCTCTCACTT GGAGTATTAA TAGTTTCCTT GTTTCTACTC 125281 ATAATTCATT ATTCCAAAAA AGTTAAGAGG GGAAAAACAT AGATCTCGTC ATTTCCCTTT 125341 TTAAACCACT TTACCTTCAA GGTTCCAGGT GATCTAAGCC TTGCCCTTCT CTCATACCTA 125401 GTTAATTAAC TACACTCTGT TCATGAATAC ATTAGGCTCA CCTACCTCAA GATCTTTTTG 125461 CTCAGCCTGA TTTGTTCTCT CAGCCTTTTG CATATTTCAT GTTTATGTCT TGGCCCAAAT 125521 GTCACTTCCT TAGAGGGGCT TTTTCAGAGC CTTCAATCTT AGGCAGTTCC CCCAAACGCA 125581 GTCTTACACT TGTATCACAT TGGCCTGTTC AGTTTTCTAA AAAGCACATT ACCATTAAAA 125641 GAAATGCTCT TGTTTGCTTT GTATATTTTC CACTTCTACA CATTATGTTG CAAAGTTCAT 125701 AAAGGCAGGA TGTTGATTTT CTTCACAGCG TTACCCTCAG CACCTAGAAC AGTGCCTGAC 125761 ACATAGTAAG CATTCATTAA AGGGCTAAAA ATATTTCATG TTTTAAAAAT ACTTGGGAGT 125821 CTAATTAGAC AATACTTTTT TTCAGCTTAA TGGTAGTATT TTAGCTTCAC TATTTTAACA 125881 AATCAAAAAT TTGCAATAAA TCTACAATGC CATTACCCCC CAAAATCTTT TTCATGTTTT 125941 GCATTTTACG TATTATTTTC CAGGCCTTAC CTGCATGTCT GCATAATCAT AACTGACTAA 126001 TTTTGGAACA GCTGGTAATT ATTTGAGCTT TACTGAAATT TTTTCATGAG GCCAATTCTA 126061 CCCTACTGAA CTCAAATTTC AGTTAATGAT GACCTCATTT TGATTGCTGC TGTAAAAAAT 126121 AAGATTTCGG AAGAGGAATG AATTCTTGTA TTACTGTGCGT AGGACTATGG GTTTTTTTTT 126181 GTTTGTTTGT TTGTTTTGAG ACGGAGTCTC ACCCTGTCAC CCAGGCTGGA GTGCAGTGGT 126241 GCGATCTCAG CTCACAGCAG CCAGGTTCAA GTGATTCTCC TTCCTCAGCC TCCCGAGTAG 126301 CTGAGATTAC AGGCACGTCC CACCATGCCC GGCTAATTTT TTGTATCTTT AGTAGAGATG 126361 GTTTCACCAT GTTGGCCAGG CTGGTCTCGA ACTCCTGACC TCGTGATCCG CCTGCCTCAG 126421 CCTCCCAAAG TGCTGGGACT ACAGGCGTGA GCCACCGTGC CCGCCCCCGT TATTCATTTT 126481 TCTTATTAAC ATTCTTTGAT GATTCTTATG GTGTTGTTAC AGTAAAACAT TTCTAACAAT 126541 TATTCTAACA ATTATTCTTG ATGGTGTATA TGAAGAATTT ATTGTCGTGT ATTTGTAAGC 126601 TGCTATGTGC AGAAGAATTT CAGTCAAATA AAGTTGGTAA GATAGGTATG TAAGTAATAT 126661 GAAAAAAGAT AGAAGGTGAT GAGTGACTTA GGTATAAATT AAGTACAATA GAAATGTTGA 126721 GGAAAGAAAA ATTTCTTGTA ATAGAAATC GAAGTACAAA CTGGGCATGG TGGTGTGCAT 126781 CTCTAATCCC AGCTCCTTA GAGGCTGGTA TGGGAGGATC ACTTTAGCCC AGGAGCTTGA 126841 GGCTGCAGTG AGGTGTGATC ATGTCACCGC ACTCCATCCT GGGTGACAGC AAGACCGTCT 126901 CTCTTTTTTT TTTTTTTTGA GACGGAGTCT CCCTATGCT GGAGTGCAAT GCGCGATCT 126961 TGGCTCACTG CAACCTCTGC CTCCCAGTTT CAAGTGATTC TCCTGCCTCA GCCTCCTGAG 127021 CAGCTGGGAT TACAGGTGTG CGCCACCATG CCCAGCTAAT TATTTTGTAT TTTAAGTAGA 127081 GACGGGTTCT CACCATACTG GCCAGCTGG TCTTCAACTC CTGACCTCTT GTTCGCCCAT 127141 CTAGGTCTCC CAAAGTGCTG GATTACAGG TGTGAGCCAC CCCACTTGGC CCCGAGCGAG 127201 ACCCTCTCTC TAAAAAAAAA TAAATAAATA AATCATAAAC CTGTGGATTA TTGTAGCATT 127261 GTTTCTCATC TGTCAAAAAT ATTTCATGAC TATGCATAGT TTGAAAAGGC AAGTTTGTCC 127321 CTGGGCAATT TTCAAAATAT TTCTTTAATG TGTTTTCACA ATACTGTTTA CCTAATAAAT 127381 CTTAAGTTTT TAAAAGCAAA ATTAAGCCAG TAATTTGAGT CCAATTCCAA TCTCTTATGA 127441 GTCATTGCTT AAATTTCAAA AGGGTTTTAT TTTTTTTTTA GGTTTGTTCT GAGTAATGAA 127501 TACCCTATTA CTATGATACT AGTATCTTCC TTAATTATCC TACTCATTGT CTCAACATTC 127561 TGACAGTTGG ATTGAGCATA TTCGTAAGTA AAATTGTTTT AACTGTATGA TTACTTTGA WO 00/09525 PCT/US99/17712 EPI-109 642 127621 TGTTAGGTC CAGTCZCA CATACCTCGG TAGATGTGTT CTTACAGTTT TGTATTCCCT 127681 TGAAATGTAA CTGTTC:CTA TGTTACAGCC TTTATAACCT TCAGTTACTT GAAATGAACA 127741 AATTCATTCA AATTCCA2CA CTTAAAAGTT TTAAATTACA TTTTGGATAA ATACCAAAGT 127801 GTTTTGTTGA TGATGTA:GT ATAAACAAAT TGTAAATATT AAACGTTAGT TGTTACGATT 127861 AGACCTATAT AAAACASAT ATGCAGTCTA CTGAATAGCT ATCAGCCTCT AACATGTTTA 127921 GTGTCATTTA GAAAATGCTT TCTAAATTGC CAAAAGCTCA TTGTCTAGGT GATAACAAAT 127981 TTACCATTTC GAGGAAGTTG ACTTTCTCAT TTTCATGTCT TCATCAGTCT TACTTGATGA 128041 GATTCATTCT TCTAGTCMGA AGAGAGTTTA GACTGCTCAC TTTACTCATA TTTTGAGTTA 128101 GCTTTTCTAT TTAGAG::CA CTTGGTTGTG GAATATTCAT TTATAATTTG AATCTACGTT 128161 GTGTAATGGG ACCTAA::TT TTTTTCCTTT GTTTTTGTTG GAGTCTCGTT TTGTCACCCA 128221 GGTTGGAGTG CAGTGGCGTG ATCTTTGCTC ACTGCAACCT CCACCTTCCA GGTTCAGGTG 128281 ATTCTCCTGC CTCAGTCTCC CAAGTAGCTG GGATTACAGG CATGCTTCAC CACGCCTGGC 128341 TAATTTTTGT ATTTTTAGTA GAGATGGGGT TTCACCATGT TGGCCAGGCT GGTCTCAAAA 128401 CTCCTGAGCT CAAGTGM:CC TCCTGCCTTG GCCTCCATAA GTGCTGGGAT TACAGGCGTG 128461 AGCCGCTGAG CCTGGCCCCA GAGTTTGTTT TGTTTTGTTT TCAAGACAAG ATCTCACTCT 128521 ATTGCCCAGG CTGGAGAGCA GTAGTGCGAT CATAGCTCAC TGCAGCCTGA ACTCCTGGGT 128581 TCAAGCTATT CTCCTC-"TC CATCTTCTAA AGTGCTGTGA TTACAGGTCT GAGCCATGAT 128641 GCTTGGCCTC TGTTTTTGTT TGTTTGTTTT GGGGGACAGG GTCTTGCTTT GTCACCAAAA 128701 CTGGAGTGTA GTGGTGCGAA CATAGCTAGC TCACTGCAGC CTCCATCTCC CACGCTCAAG 128761 CAATCCTCTC ACCTCAGCCT TCCAAGTAGC TGAGACCGCA GGTGCGTGCT ACCATGCGTG 128821 GCTAATTTTC TATTTATATA TTTATTTTTT GGTAGACATG AGGTCTTGTC ATGTTTCCCA 128881 GGTGGTCTTT AACTCC7GC CTCAGACAGT CCTCCCGCCT CAGCCACCCA AAGTGTTGGG 128941 ATTACAGGCG TGAGCCACCA TGCGTGGCAT AATTTTTTTT AAGTAAATTA TTTTTTTATC 129001 TTGAGTATAG AAGTGATTCA TGTTCATTGT GGAAAATATG AAACATATAG AAAAACAGAA 129061 AAGATTACAA AACATCTAAT CTGAAATGGT TAAGATTTTG ATGAGAACAG TCTCATCTCA 129121 TTTCCGTATA TTCCTGCCAG CCTATCCATC ATTCTTCGTA CATGTTTATC TACATTAAAA 129181 TTGGTGTTAT ATTTTGGAAA CTTTTTGTTT AACTACATTC TGAACATTTT TCATGTTTTA 129241 AAATGTCATT TTAATGATCC CAGATCCTAT TCAATAGATG TACACACACC TATTTAACTG 129301 GTCCACAATT CTTGGATATG TAGGTCGTTT CCTTTCTCTC TTTTTTTTTT TTTTTGGCTA 129361 CTACTTAATA GTTTCTCTGT ATAGAATGTG GTATTTTGAA AGTGTATCAA GCTTTACATT 129421 GGTAGTATTC TTGCATTTAA TAAAGGGCAG TGGCCTTTGT TGACTGACAT CACAATATTT 129481 TTATAAAATT TGTTATTTGC TTTACAGAAA TTTTGAAAAT TATTGTAGAA ATGTTTTTAC 129541 CTCATATGAA CCACCTGACA TTGGAACAGA CTTTCTTTTC ACAAGTGTTA CCAAAGGTAT 129601 AATACTATTA CCTGAAAATA CATGTTATAA GGAATCTAGC CTCAGTCTTA GATGATTTAT 129661 TATTAATTAT GGCTCTCTTT TTCTAATATA TCAAATATAT TCAAAATAAA AATAAGGAGT 129721 AAGTAGATCT CATGTGAGAC TATAATGGTG TTAGTGTGAT CATTAGGCAG TTAAAAACTG 129781 TTACAGGCTG GGCACGGTGG CTCATGCCTG TAATCCCAGC TCTCTGAGAG GCTGAGGTGG 129841 GCAGATCATC TGAGGTCAGG AGTTCGAGAC CACCCATGGT CAACATGATG AAACCTCGTC 129901 TCTACTAAAA GTACAAAAAA TTAGCTGGAC ATGGTGGCAG GTGCCTGTAA TCCCAGCTAC 129961 TTGGGAGACT GAGACAGGAG AATTGCTTGA GCCTGGGAGG CGGAGGTTGC ATTGAGTCAA 130021 GATCGTGCCA TTGCACTCCA GCCTGGGCAA TAAGAGCGAT GCTCCGTCTC AAAAAAAAAA 130081 AAAAAAAAA AAGAACTTAT ATTTTCAGAT TGTGTGGTTC CTTTACTAAC TGAATTTAAA 130141 TTATTTGTAG TCAATTTTAA ATGCTCTTGT ATTTTAAAGC CACTGTACTC CAGCCTGGGT 130201 GACAGAGTGA AACCCTTAAT TCAAAAAAAA AAAAAAAAAA AAGAAAAGCT GGAATATTGG 130261 CAAAATCAAG TAACTAAGAG AAAACATTAA ATTCACAGAA TACATTATTA CATTTTAGAT 130321 ATATATGGTA TATGTTTTCT CTGAAAAGCA CAAGCATACC TTTTTTGTTT TAAATGGAGG 130381 GAACTAAAGA TACTTTGGTG CCAAAATGAA ACATTATTTG TAATTAATCT CTTATTGAAA 130441 TGGGTTTCTA ACTTTAGCTT TGAATCGTAA TCTTTCAAAT TTCTTGTACT CATAGTCACT 130501 TGATGATTCT CTATCTGAAA TATTTCTTAG AATTTGTTCT TGACCACCAG AAAAAGATTC 130561 AACTGTTACA TAGATGAAAA TGGATGTTGA GTGTTAACAG GCCTATGGGA AACAGTATTT 130621 TCTTTAGCTA CATTGTATTG TTGACTGTGT TGCTATTCTT ATAATGTTTA GGTCATTTAA 130681 ATTGTTAGAA AGATCCAAGT ATTAAGATCT AGGGTGGCTA ACTTTTCACA GACAAAAAGC 130741 TTGTTTGTAA GGTCATTTAC TATACCCTTA ATTCAGGAAG GTTAGCTTGA ATTGGGTCAA 130801 AAGGAAACTG GTTAGAAAAT AAGTGAGTAG TGAATAGGCG ATTCAGTGCA AATTCCTTCC 130861 AGAAAATACC CTTGTAAATG ACTGTATGAA TGTGGATTCT TCAAGACAGT CAAATTTATT 130921 GTGCGAAAGT AATACTTTTA TTTTTTGCAT CTCTAAAACA TGAACTTTGA GTGATTTTTT 130981 AAAAAAATTG ATGCTATTAA ATAGATTCAA ACCATAGAAA TGGAAAATAA ATTTCTGTTT 131041 GGGGCTTTTG GGGGGATTAT GTTGTAAAAA TACCTTTTCT CTGTATTTTG TGCTTAATTA 131101 GGTACAATTG TTAAGCTAGA TGATAGCCTG TGGATGTTAC TAGTGCAAAA TCAAATTATC 131161 GTATTGTGTT TTCTCTGTAA AGTTTTGTCT TGTCTTTTCT AGTGATTTCT CTTATTCCTG 131221 TTTATTACTT GATTTGTTTT TACAGACTGT GAAATTATTC GATGACATGA TGTATGAATT 131281 AACCAGTCAA GCCAGAGGAC TGTCAAGCCA AAATTTGGAA ATCCAGACCA CTCTAAGGAA 131341 TATTTTACAA GTAAGTCAAA TGTATTAGAA AGCAGGAGAG AGAGGGAGCT TAAAGAATGT 131401 CAAAATTTTT ATACTGATAC TGATTAGCTA TGTATTCTTA TGTAATGGCC TAATGTTGGA 131461 ATTAAATTTA TAGAATTAAA GACGTGAATA TAGAAACATG AATTCTGAAT AATAAACTCT 131521 TATAAGAAGA GAAGTCATCA AGCTACTGA CCCTACCTGT ATTTTCAAGG ATATGTGTG 131581 AACACCTGCC ATGTGTTTTG AAGTTTGTGT TAGTATTCTA AATGGCTAGA CAGTTGTTCC 131641 AGTATTTGTA CTTCTGATAG ACTAAAGTTC TGTGAAAAGA GGAAGAGACT GTGTTTTGTT 131701 CATTGCTGTA TTTGTAGCAC CCAGCATGCT GACTAATACC TTTTCAGTGC ACAAAAAATA 131761 TATTCTAAGT GAAATTTCCT TCCTTATTCA CAGACAATGG TGCAGCTCTT AGGAGCTCTC 131821 ACAGGATGTG TTCAGCATAT CTGTGCCACA CAGGAATCCA TCATTTTGGA AAATATTCAG 131881 AGTCTCCCCT CCTCAGTCCT TCATATAATT AAAAGCACAT TTGTGCATTG TAAGGTGAGT 131941 AAAGGTCTAA TTATACTTTG AATGGTATAT AATCAATGTC CATAGGGCT GAGTAAAATA 132001 ATGTTTGTAT AAGATTTTAC ATTTTAGTCT ATATTATTGA AATAAACTTT TCCATAGAAT 132061 AAAGAACATG TAAGTAAATA ATTGTTGCAA AAAAAGTGGT TTTAAGGAAG TCATTAAAAG WO 00/09525 PCTIUS99/17712 EPI-109 643 132121 TGGCTTTTTG GGGTTTTTA GTTTTATCTT ATTTCCCCTC TATAAAGAAA GAAGTTTTAA 132181 GAATTTGTGT TGAGACAGAC ACAGGGATCC TGAAATAGTT ATGTCATCTT GCATTGACCA 132241 ATATTCAATT ACCATTATGA TTAGATGTCA GAACTTCCTT TTATAAAGGA AAGTTAATCC 132301 TTATTTAGTC CATCTCTACA TGCCAGAGGT AGCCTTGAGG CACAAAAGCT TGCCTAGAAT 132361 TTATGGGTCA CAGACAGTTT TAATATTGCT ATTTGTTGGG CGAATGAAAA TCACTAGTTA 132421 ATTAATACCT CTCTTTGCTG ATAGGATGCT AAAAATGTCA CGCACCTGGC CTAATGTTAC 132481 CCTTTTTTAG TTCTGTATTT GCAAGATCAT GGAAGTCAGA AATAATATTT TATACATGCT 132541 TGCATCTCTT GAAGCACACT ATATTTAATG GATGTTCACT AAACAATGAA TGAATATGTG 132601 ATTCAGTAAA TTTATGATCT CTAATAGTAT GAATTAAAGT AAATTTGGCT CTTGAGCTTT 132661 GATTTGTTTT TTCTCTCATT TTTATTTATC CCTAATCAGA ATAGTGAATC TGTGTATTCT 132721 GGGTGTTTAC ACCTAGTTTC AGACCTTCTC CAGGCTCTTT TCAAGGAGGC CTATTCTCTT 132781 CAAAAGCAGT TAATGGAACT GCTGGACATG GTTTGCATGG ACCCTTTAGT AGATGACAAT 132841 GATGATATTT TGAATATGGT AATAGGTGAG TGAAGAAAAC TTTCTGCTTA GTATATGGTG 132901 ACTATAAATC ATGTATCAAT TAAAATTGTC TCTAATGATT CATGTTATTT TCTTACTAAT 132961 TATGCATTAA AATTGATTTA AATCTTACCA AATAAATTTT TAATCTTGAA ATTTGGAATT 133021 TGTAAAATTT ATTTTGGGTA CCTTAACCTA GATTTGCGTA TTTAGTTACT GTAATTTCTC 133081 CACAATGATT AACTTATATA ACTTTATAAT CTCTGAGGTT GTCCATATTC AGAGACAATA 133141 ACTTTCACAT TTTTTTAACC ATAACTGATA TTGAGATGCA GTTTATATTT CCTTCCAGAA 133201 TACATATAAA TACGTGCATA TGTGTATGTA AATATGTCTA TTCTCATATA CATATTATAA 133261 TGAAATAACT CATTTTACAT GTGATGCACT TTATACTAGT TTATTTTTAT TTTATTTTAT 133321 TTTTTTGAGA CAGAGTCTCA CTGTGTAGCC CAGGCTGGAG TGCAGTGGCA CAATCTCGGC 133381 TCACTGCAAC CTCGCCTCCC GGACTCAAGC GATTCTCCTG CCTCAGCCTC ATGAGTAGCT 133441 GGGATTATAG GCGTCCGCCA CCACACCTGG CTAATTTTTG TATTTTTAGT AGAGACAGGG 133501 TTTCACCGTC TTGGCCAGGC TGGTCTTGAA CTCCTGACCT CAGGTAATCC ACCTGCCTCA 133561 GCCTCCCAAA GTGCTGGGAT TACAGGCATG AGCCACCGTG CCCAGCCAAT ACTAGTTTAT 133621 TTTTAAAGAA TTGCTGGTCG TAACACACTT CATTGATTTT ATCACTCATT AATGGATTAT 133681 GAACAAGAGT TTGAAAAACA ATATAAAGGC AAAGTTTGCA TTCAAAACTT TGGTATAAAG 133741 AGAGTAAGTT GGTTTTCTGC AGTGTATCAG GCACCTGTTG CTCTGCAACA CACCACCTCA 133801 AAATCTATTT ATTCACTATT TATTTATTCA TGATTCTGTG AGTCTGCAGT TTAGGGTGGG 133861 ATGTCCTGAG ACAACTTTCT CTGATCCACC TGGGGCACTA GCTCACCCAT GTGACTTCAG 133921 TGACTTCATT CACATCTGGC TGTTGGCAGA GGCAGAAGTA CTTGAGAAAG CCATGTGCAT 133981 CATCCAGCAG GTTCACCCTA TCTCAGATAC CTGATGCCAG TGGTTTCAGG GTTTCTAAGA 134041 GTAGCAAAAG TGTGAGCAGG TCGCTGTGTG CTAGCACTTT TCAAGTTTCT GCTTGCCTTA 134101 ATTTTATTAT TGTCCCCCGG GCCACAGCAG GTCATAGCGT TTAGCCCAGA GTCATTGTAG 134161 AAAAGTGTGG ATTCACAAAG GGCAGTCATT GTGGCCATTT TTATAAATAA TCTACCACAG 134221 ACTGAGTAAA AGCCTTGCAT GAATACCATG GATATTAATT TGAATTCTTC CTTTTTAGAT 134281 TTTCTTTCCT TAGCAATTTC TTTTGTCATT TTGGATTAGA ATTATATCTG TAGAATATTT 134341 CAGTTATAAT AGGGTACAAC TTTTATTCCA CTGAACATCT TTAGTTTTAT TTAGGTCATC 134401 TGGTAGGTAT AAACTTCAGA AGTTAATATT CAATATTTAT AAAAACCATT AACAAGTGTG 134461 ACACTTAAAT AGTTTAAATA ATTCTTTTGA CACAACTGTT TCCAAGTTGT GTTACGTATT 134521 TTAATTCAAT CAAATGTTGA AATTGTTCAG TAGATAGTTT TAATTATAGG AGAAACTCAC 134581 CCCCATGACA TTTGGATGTC TTAAAAGTTC TGTTATCTTT CTTTGCAGTT ATTCATTCTT 134641 TATTGGATAT CTGCTCTGTT ATTTCCAGTA TGGACCATGC ATTTCATGCC AATACTTGGA 134701 AGTTTATAAT TAAGTAAGTT TGTTTGTTAT TTTTTACTTT TTAGAAAATG TTTTCCATAT 134761 TCCCCAATCT TAATTATTCA TGATTCTTTA GATTGCATTT AAAACATTTT GTGTGAATTT 134821 AATGTTCACT GACACTGCTG TCTGATAATC CAGATATTCT ACATCTAGCT CTCAAGCCAA 134881 ATTGGACTTC TTTACCCTGT GGCCTCTAAA ATTAAAAAAA ATGTTCTTCC TAGTTAGCTA 134941 GTACTTCAGA AATAATGGGC CATGGGCCAG ACTAGAACTT AACCACTTTT CTTCTGCTAC 135001 TGTTGTTTAA CCAGCTATCA AGTATCCTAT TTCTAGGATT AGATAAATTG ATAACTATAA 135061 TTAAAACTGA ATATAATCTT TTCATTAGGT ACTTTTAAGT TGTTCACACT TAATTCCATT 135121 TGTACAGTAA TTTTAACTTT CTGAAACTGA AGCATTTTAA AGGGTCACCA GGGATAGTGC 135181 CTGTAGCATT CATCAGATTC TTAGGGGTGA GAGGAGATGT GGTTGAGATG TAAAAATGGT 135241 TAAGAATATC TACTTTATAC ACATACATAA AACATTAAAG GTCAGTGTAT TTTCAGGTCT 135301 TAGGTACTTT TCTTGTACTA CCAGGACATT AAGTTGCCAT TCAGTGGTTA AGAGTGTTGC 135361 CTGGGAGCTC TATCACATGT GCTTAAATCC ATTCTTGAAA TCATTTACTC CTTCTGAGCC 135421 CTTGGGCTAT TTGGTTAATT TCTCTGAACG TTAGTTTGCT CATCTGAAAA TGGAAATAAT 135481 AATAGCAACT TCTTGACAGG GTTATAGTGA GAATTGAGTT CATCACTGTG AAATGCTTAG 135541 AAATGTGCAT GACACATAGT TAATACTCAA GGAATTAGCC ACATCACTAT CATCATCACT 135601 TATTATCTTC CACTCTTACC CTCTTCCAGT TCATTTTCTG CCCAGCAGAA TGATCTTTTA 135661 AAAAGTAAAT CAGATCATGT TACTCTATTG CTTGAAGTCT ATCCCATTTG ATTAAGAATA 135721 ACAACCTAAT CCTCTGTGGA TGCTGCCTCC TTCACCAGCC TGTCTCATGC TGCTCTCCCT 135781 ACTCTTAGTT CCTCAAACAT ACCAAACTCT CCTGTCCCAG AGTCTTTTCG TGGTTTTTCC 135841 ATCTGCCTAG GATGCTTCTC TCTCCTATTT TGTGTACCTT GCTAACTCCT GCTTACTGTC 135901 TTTCAGTTCT CAGCTTAAGA GTTATATCTT CATGATAACA TTCTTTGATA TCCTTACCCT 135961 AAGATTAAGT TAGATTGATA TCCTTACCCT AAGAATAAGT TAGATTAGGT CTCTCTATTG 136021 TAGCACCTTA GACTCTGTCA TTTGACAAAT CACAGCCCTA ATTAATTATT CTTAAAATTA 136081 TTTAACATTC TCTCTCATGC TAGACCACAA GTTTCATGCA GGTAAGGCGG AGATTGTGTC 136141 CATTTGTTTG ACCCCTTTGT CTCCAGGGCC TGGTAGAATG CCTCATACAT AGTAAGAATT 136201 CAATTAATAT TTTACACAGA GAAAAAATTA GCAACTTATT TAAACAAATA TAACTGCTTC 136261 AGAGGTAAAC TGGGCACATC TTAGTTATAT TATGTGATAT ATGATGCTTT TTGATTGTTT 136321 TTTTAAATGT TCTACAAGGT AGATATTGTT AGAGGTCCTA AGTTACTTGA TGTGTTACTT 136381 GTGGTGATTG TATTCTTTTC TTTTTATTCA TTTAGGCAGA GCCTTAAGCA CCAGTCCATA 136441 ATAAAAAGCC AGTTGAAACA CAAAGATATA ATTACTAGCT TGTGTGAAGA CATTCTTTTC 136501 TCCTTCCATT CTTGTTTACA GTTAGCTGAG CACATGACAC AGTCAGATGC ACAGGTAAAA 136561 TTTGGGCTAA TAGCATTTTA AACAGCAACT CTTATTTTCT TTGGCAGTTA GTAAATCTCA WO 00/09525 PCTIUS99/17712 EPI-109 644 136621 TTTGAATGTC TGGGTCAGTC TATTTAAGAG GATTTTAATT TATTTCATTT GGGTGTTTTT 136681 TTTTGATCTG TGCATTATT TATATCCCAT AATTACTTTT CACCCAGAGC ATTGTATTAG 136741 ATTCCTAACT GCTGTCATTG CCTCTGGGGT CTGCCTGGCT CCCTCTTTGC TTGGTAACTG 136801 GTTGGTCACA GCATTCTTCT CAGAATCCTT TCATTCTTTT CTGCATGAGA ACAAAAATTC 136861 TTTTGTTCAT ATTTGTATAA GATCTGATAT AGCTGCAATC AATCTTGCAT TTTTTCTTCA 136921 CCAACGCATT GCGACCTTTA GGGATACAAG TATGTTTGTG CATGTATATG TATGTATCAG 136981 TCTTTTAAAT TTGATATAGT CATACATTTG TTTTTATTTT GAAAAGTTAG AGTGTTGAAT 137041 TGGTATCCCA TTTATGAAAC ATTATATTCT AAAAATTTGT AGTACGATTA TTGGGAATTA 137101 TAACTCATTT TCCTGTAACA CTGTTATACA TAGTACCTTT TGCTTTCAGA CTAGCCCTCA 137161 ATTTTATTTA ACTATAGTAG TCCTAAATTA TAAGATTAAT AGTACTCAGG ACCTAACAGT 137221 TATATGTCAT TTGTTTTTTT TTTTTTTGAG ATGGCGTCTC ACTCTGTCAC CCAAGCTGGA 137281 GTGCAGTGGT ATGACCTTGG CTCACTGCAG CCTCTGCCTC ACGGGTTCAA GGGATCGTTC 137341 TGCCTTAGCC TCCTGAGTAG CTGGGATTAT AGGCGCCTGC CACCACGCCT GGCTAATTTT 137401 TTTAGTAGAG ACGGGGTTTC GCCATGTTGG CCAGGCTGGT CTCGAACTCC TGACCTCAGG 137461 TGGTCCACCC GCCTTGGCCT CCCAAAGTGC TGGGATTACA GGTGTGAGCC ACCGCGCCCA 137521 GCCTATATGT AATAATTTTA ATGGGACCAT GAATTGAATA TTTCTTCCTT GAATAGCAAT 137581 GACATAGCCC CTTCTATTGT ACATCTGCAA GCTGATACAG GGAATTCCTT TGTACCTGCG 137641 CTCTTCCCTG CCAGTCAGCT ATGGGGGTGA AACTGTAGGG GTTCATCCAA GTCCTAAAAC 137701 TGGTAGCAAC TCCTAGGGCA GGGCTGATCT GGAAGGACAG ACCCTAGGGG AGGGTGGAAC 137761 TTTAAAAAGA AGTTCTGAAG GTAGTAAGAA GGAAATGAGG AGTAGTGTTA GGAAGGGGCT 137821 AACTTTTTTC TTCTTGCTTC TCTTCTTTAT CTCACCTGCC CCTCCCCTTG TATCCCTTCT 137881 TCCTTTTTCC CTTTCCTTTT TTGTCCTCAC TTCATTCGTG CATCCTTTCT GATTCCTCTT 137941 ACCTTGCTAA AAGGAGAAGT TTGTTTGGGT ATCCTATATC AATGGCAGGA AGGTTGTTTT 138001 CTTCTTTACC TTTATCCTAT AGATTCATAT TCTCAACACC AACCTCCTCC TTTTTCAGTT 138061 TCCTTCTTGC TTCTCTTGAC ACCACAGAGT TTGCAGCTAG TACTTGGAGA GGAAAATTAA 138121 ACAGAGATAC TTGGACCAAG AGTAAGATGA AGAAAGTCTA AACAACAGTA TAGTCTATAG 138181 TGGCAAGAGA GAGTATGGGG GCTGCTTAGC CAGGGTGGCT GTACATAAAG TATATCTTCA 138241 GTTTATATAA ACTGCTTATA GATGGAAATC AGAAAATTTA AATTCTCTTA ACTGTCCAAG 138301 AAAATTCTCA TTTTTTCAAA TTTGGGACTG ATAAATGTGA CCAGTTCTGC TTACTGTCCA 138361 TTGCCTGAAA TGGAGCTTTG AGGTGGACTG TATAATTTCT TCAATCTTAA CTCCAAATTC 138421 TGATCAGCGA CGCCCTCTGC TGTTCACTAT TAATATTTAT TTACCAATCA AAGTAAAGTA 138481 TTGAAGTTTT CCTGGCAGTT TTCACTTTGT GTTTTAGTCC ATTTAGGCTG CTATAACAAA 138541 ATCCCTTAAA CTGGGTAAGG GATTATAAAT ATTAGAAATT TATCTCTCAC AGTTCTGGAA 138601 GCTGGGAAGC CCAATATCAA GGCACCAGTA GATTTGGTGT CTAACGAGGG TGTGCCGTCT 138661 GCTTCAAAAA TGGCCCCTTG TTGCTGCATC CTCACTTAGT GCAAGGGGCA AGACAGCTCC 138721 CTTCAACCTC TTTTATAAGG GCACTTATGT CATTCATGAG GGCAGAGCCC TCATGACTTA 138781 ATCACTTCCC CAAAGGCCCC ACCTCTTAAT AGTATCACAT TGGGTGTTAG GTGTCTGGGA 138841 GGACACCAAT CTTCAAGCCA TATCATCTCA CTTGGAAAAA AGTCAAAATA AAACCAGTAG 138901 ATTTAATTAA TATTACACTA TTTATAGAAG CATGTGATGT ATCATTCCTT GTATTAATTT 138961 CCTGGGGTTG CCGTAACAAG TTACCACAAA CTAGGTGGCT TAAAACAATA GAATTTTATT 139021 CTCTCACATT TCTAGAGGCA GAAGTTCACA GTGTGTCAAT AGGGCCATGT TCTCTGGAAG 139081 GCTTTAGGGG AGAATATATT TCATATCTTT CTCTTAGCTT CTCGGTGTCA CTGGCAATCC 139141 TTAGCTTACT TTGGCTTTCT GTGTCTTCAC ATCATCTTTT TATAAGAACA CCAGTGATAG 139201 TGATTAAGGG CATACCTTAC TTTAATATGA CCTCATCTTA ACTAATTATG TCTTCAATAA 139261 CCCTATTTCC AAATAAGGCC ACATTCTGAA GTATTGGGAG TTAGAACTTA AAGCTTTTTG 139321 GGAGGGACAC AGTTCAACCC ATAACAACCC CTAAAATCGA TATTTATTCT CAATTAAGTC 139381 TTGAAATTGG TTTCAAAAAG AGAATATTCT ATTAGAGTTT TTAATGTATA GTTTTAACAT 139441 ATAGTTCTTT AGCCCCCAAT TTTTTTTTTT TTTTTTTTTT TTTTTTTTTT TTTTTGAGAC 139501 GGAGTCTCGC TCTGTCGCCC AGGCCGGACT GCGGACTGCA GTGGCGCAAT CTCGGCTCAC 139561 TGCAAGCTCC GCTTCCCGGG TTCACGCCAT TCCCCTGCCT CAGCCTCCCG AGTAGCTGGG 139621 ACTACAGGCG CCTGCCACCG CGCCCGGCTA ATTTTTTTGT ATTTTTAGTA GAGACGGGGT 139681 TTCACCTTGT TAGCCAGGAT GGTCTCGATC TCCTGACCTC ATGATCCACC CGCCTCGGCC 139741 TCCCAAAGTG CTGGGATTAC AGGCGTGAGC CACCGCGCCC GGCCTGCCCC CAATTATTTA 139801 GTTTTTCTAT AAACAGGGAA ATTTATTTGT GTGGCCCTTA GAACTAATTT AATTTCCACT 139861 CTAATTCCTA CTTATGTTTA TATAATGCTT TTAGAAATTT GTATTATTCA GAAAATAAAC 139921 ATATACTATT GTATCTGTTG CCTACACTTA GATTTTATTG CCTGCTATAT TTAAATTTTA 139981 TTAGTATTTT AATTGTTTTA TTAAAGAAAG AATGTGCCTG TAATCTCAGC ACTTTTGAGA 140041 GGCCAAGGCA GAAGGATTGC TTGAGCCCAG GAGTTTGAGA CCAGACTGAG CAACACAGGG 140101 AGACCCCCAT CTCTACAAAA AATAAAAAAA TTCTCCAGGC CTCATGGCAC ATACCTGTAG 140161 TTCTAGTTAC TTGGGAGACT GGGGTGGGAG GATGCATTGA GCCCAGGAGA TTGAGGCTGC 140221 AGTGAGCCAT GATCAGGCCA CTGTACTCCA GCTTGGACAA CAGAGTGAGA GCTTGTCTAG 140281 ATAGATAGAT AGATAGATAA TCTAAATAGA TAATAGACAG ATTATCTAAA TAGATAATAG 140341 ACAGATTATC TAAATAGATA ATAGACAGAT TATCTAAATA GATAATAGAC AGATTATCTA 140401 AATAGATAAT AGACAGATTA TCTAAATAGA TAATAGACAG ATTATCTATC TAAATAGATA 140461 ATAGATTATC TAAATAGATA ATAGATAGAT AGATTAGATA GATAGATAGA TAGATAGAGC 140521 TTGGACAACA GAGTGAGAGC CTGTCTAGAT AGATAGAAAC AAAGAAAGAA AGAAAGAATG 140581 GTGCTCATAT TTTAAAGCAT TGAAAAATGG TCTTCCTTGC TTATATTACC CACACCTTCT 140641 TTGTTGGCAT TAAGATGCAA ACTTTGTTTT AAACAGTTGA GTAAATCAAA GATGGGACTG 140701 TTAAGTTATT TGTGTTATTT ACCTGCTTTT TGAAAATGTA AAAATAAAAC TCTAGGTTTA 140761 ATTAGTAGTA TGCTATTTAG TAATGAAGTA AAGCTAGAGG CTTCGAACAA ATCTTGTGTA 140821 ATTTCCTCTT GAATGAGAGA GAAAATTTAA AGTAAGCAAA CAAATAAGTT GTGTGTCACC 140881 ACTCATTCAG TCATTTAACA AGTATTTCCA GAGTACTTAT TCTGTGCCAG GAAATGTTGT 140941 AGGTGCCCTC AACAACTTAG AGTCTAGCCT GAGACACAAG TAAGTAGGTA ATTATTATAG 141001 AATGGTATGA TCTTTGGAGG ACTGGGTATT GGCTGGCTCA TGGGAGTACA AGATAGGTAC 141061 CCAGTGATGA AGTCAGGAAA GGTTTCTTAT GGTGATATGA TGACGTCTAT GCTGATTATA WO 00/09525 PCT/US99/17712 EPI-109 645 141121 AGGTCAGTGT AGAATAAACT TTGTGCTTTT AAATTTGCAT AGCACTGTAT TAGAGAGTTC 141181 ATCTTCAAAA TAATCGAAAA GGCTGAGTGT GGTGACCCAT GGCTGTAATC CCAGCACTTT 141241 GGGAGGCCGA GGTGGGCAGA TTGCTTGAGC TAGGAGTTCG AGACCAGGCT GGCCAACATG 141301 GTGAAACCCC GTCTCTACTA AAAATACAAA AATTAGCCAG GAGTGATGGT GCGCACCTGT 141361 AATGCCAGCT ACTTGGGAGG CTGAGGCAGG AGGATCACTT GAACCCAGGA GGTGGAGGTT 141421 GAAGTAAGCC GAGGTCATGC CACTGCACTC CAGCCTGGGC AACAGAGTGA GACTCCATCT 141481 CAAAAAAAAA AAAAATGATC AAAGAAAGGT GAATTTTCAT CTACCCTATT TCTGCTGAGG 141541 AAAATGGACT ATTTTCAAAT ATTTTTAATA AGGGTCAAAA TGAGGGATC (2) INFORMATION FOR SEQ ID NO:2481: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1261 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2481: 1 GCCACCATGG AAACCCTTTG CCTCAGGGCA TCCTTTTGGC TGGCACTGGT TGGATGTGTA 61 ATCAGTGATA ATCCTGAGAG ATACAGCACA AATCTAAGCA ATCATGTGGA TGATTTCACC 121 ACTTTTCGTG GCACAGAGCT CAGCTTCCTG GTTACCACTC ATCAACCCAC TAATTTGGTC 181 CTACCCAGCA ATGGCTCAAT GCACAACTAT TGCCCACAGC AGACTAAAAT TACTTCAGCT 241 TTCAAATACA TTAACACTGT GATATCTTGT ACTATTTTCA TCGTGGGAAT GGTGGGGAAT 301 GCAACTCTGC TCAGGATCAT TTACCAGAAC AAATGTATGA GGAATGGCCC CAACGCGCTG 361 ATAGCCAGTC TTGCCCTTGG AGACCTTATC TATGTGGTCA TTGATCTCCC TATCAATGTA 421 TTTAAGCTGC TGGCTGGGCG CTGGCCTTTT GATCACAATG ACTTTGGCGT ATTTCTTTGC 481 AAGCTGTTCC CCTTTTTGCA GAAGTCCTCG GTGGGGATCA CCGTCCTCAA CCTCTGCGCT 541 CTTAGTGTTG ACAGGTACAG AGCAGTTGCC TCCTGGAGTC GTGTTCAGGG AATTGGGATT 601 CCTTTGGTAA CTGCCATTGA AATTGCCTCC ATCTGGATCC TGTCCTTTAT CCTGGCCATT 661 CCTGAAGCGA TTGGCTTCGT CATGGTACCC TTTGAATATA GGGGTGGACA GCATAAAACC 721 TGTATGCTCA ATGCCACATC AAAATTCATG GAGTTCTACC AAGATGTAAA GGACTGGTGG 781 CTCTTCGGGT TCTATTTCTG TATGCCCTTG GTGTGCACTG CGATCTTCTA CACCCTCATG 841 ACTGGTGAGA TGTTGAACAG AAGGAATGGC AGCTTGAGAA TTGCCCTCAG TGAACATCTT 901 AAGCAGCGTC GAGAAGTGGC AAAAACAGTT TTCTGCTTGG TTGTAATTTT TGCTCTTTGC 961 TGGTTCCCTC TTCATTTAAG CCGTATATTG AAGAAAACTG TGTATAACGA GATGGACAAG 1021 AACCGATGTG AATTACTTAG TTTCTTACTG CTCATGGATT ACATCGGTAT TAACTTGGCA 1081 ACCATGAATT CATGTATAAA CCCCATAGCT CTGTATTTTG TGAGCAAGAA ATTTAAAAAT 1141 TGTTTCCAGT CATGCCTCTG CTGCTGCTGT TACCAGTCCA AAAGTCTGAT GACCTCGGTC 1201 CCCATGAACG GAACAAGCAT CCAGTGGAAG AACCACGATC AAAACAACCA CAACACAGAC 1261 CGGAGCAGCC ATAAGGACAG CATGAACTGA CCACCCTTAG AAGCACTCCT (2) INFORMATION FOR SEQ ID NO:2482: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1861 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2482: 1 GAATTCGGGA AAAAGTGAAG GTGTAAAAGC AGCACAAGTG CAATAAGAGA TATTTCCTCA 61 AATTTGCCTC AAGATGGAAA CCCTTTGCCT CAGGGCATCC TTTTGGCTGG CACTGGTTGG 121 ATGTGTAATC AGTGATAATC CTGAGAGATA CAGCACAAAT CTAAGCAATC ATGTGGATGA 181 TTTCACCACT TTTCGTGGCA CAGAGCTCAG CTTCCTGGTT ACCACTCATC AACCCACTAA 241 TTTGGTCCTA CCCAGCAATG GCTCAATGCA CAACTATTGC CCACAGCAGA CTAAAATTAC 301 TTCAGCTTTC AAATACATTA ACACTGTGAT ATCTTGTACT ATTTTCATCG TGGGAATGGT 361 GGGGAATGCA ACTCTGCTCA GGATCATTTA CCAGAACAAA TGTATGAGGA ATGGCCCCAA 421 CGCGCTGATA GCCAGTCTTG CCCTTGGAGA CCTTATCTAT GTGGTCATTG ATCTCCCTAT 481 CAATGTATTT AAGCTGCTGG CTGGGCGCTG GCCTTTTGAT CACAATGACT TTGGCGTATT 541 TCTTTGCAAG CTGTTCCCCT TTTTGCAGAA GTCCTCGGTG GGGATCACCG TCCTCAACCT 601 CTGCGCTCTT AGTGTTGACA GGTACAGAGC AGTTGCCTCC TGGAGTCGTG TTCAGGGAAT 661 TGGGATTCCT TTGGTAACTG CCATTGAAAT TGTCTCCATC TGGATCCTGT CCTTTATCCT 721 GGCCATTCCT GAAGCGATTG GCTTCGTCAT GGTACCCTTT GAATATAGGG GTGAACAGCA 781 TAAAACCTGT ATGCTCAATG CCACATCAAA ATTCATGGAG TTCTACCAAG ATGTAAAGGA 841 CTGGTGGCTC TTCGGGTTCT ATTTCTGTAT GCCCTTGGTG TGCACTGCGA TCTTCTACAC 901 CCTCATGACT TGTGAGATGT TGAACAGAAG GAATGGCAGC TTGAGAATTG CCCTCAGTGA 961 ACATCTTAAG CAGCGTCGAG AAGTGGCAAA AACAGTTTTC TGCTTGGTTG TAATTTTTGC 1021 TCTTTGCTGG TTCCCTCTTC ATTTAAGCCG TATATTGAAG AAAACTGTGT ATAACGAGAT 1081 GGACAAGAAC CGATGTGAAT TACTTAGTTT CTTACTGCTC ATGGATTACA TCGGTATTAA 1141 CTTGGCAACC ATGAATTCAT GTATAAACCC CATAGCTCTG TATTTTGTGA GCAAGAAATT 1201 TAAAAATTGT TTCCAGTCAT GCCTCTGCTG CTGCTGTTAC CAGTCCAAAA GTCTGATGAC 1261 CTCGGTCCCC ATGAACGGAA CAAGCATCCA GTGGAAGAAC CACGATCAAA ACAACCACAA 1321 CACAGACCGG AGCAGCCATA AGGACAGCAT GAACTGACCA CCCTTAGAAG CACTCCTCGG 1381 TACTCCCATA ATCCTCTCGG AGAAAAAAAT CACAAGGCAA CTGTGAGTCC GGGAATCTCT WO 00/09525 PCT/US99/17712 EPI-109 646 1441 TCTCTGATCC TTCTTCCTTA ATTCACTCCC ACACCCAAGA AGAAATGCTT TCCAAAACCG 1501 CAAGGGTAGA CTGGTTTATC CACCCACAAC ATCTACGAAT CGTACTTCTT TAATTGATCT 1561 AATTTACATA TTCTGCGTGT TGTATTCAGC ACTAAAAAAT GGTGGGAGCT GGGGGAGAAT 1621 GAAGACTGTT AAATGAAACC AGAAGGATAT TTACTACTTT TGCATGAAAA TAGAGCTTTC 1681 AAGTACATGG CTAGCTTTTA TGGCAGTTCT GGTGAATGTT CAATGGGAAC TGGTCACCAT 1741 GAAACTTTAG AGATTAACGA CAAGATTTTC TACTTTTTTT AAGTGATTTT TTTGTCCTTC 1801 AGCCAAACAC AATATGGGCT CAAGTCACTT TTATTTGAAA TGTCATTTGG TGCCAGTATC 1861 CCGAATTC (2) INFORMATION FOR SEQ ID NO:2483: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 721 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2431: 1 CACCGCTCCT GTCAGCCAAC AAATATCCAT TGAGCGACAC CTGTGTCCCA GGTGCTGCTC 61 TGGGCCCTGG GAGAAGTGCA TCAGTGGGCT TGGTAGTAGA GGGTAGGGAT GGAGTGAAGG 121 GTAGGCAGGA AGAATGTCCC CAGGCTGGTA GGAGGTGGGG TGGGGGGTTT CAGTCTCAAA 181 ACTCCCATGA AAACCAGAGA GAAGTTTCAG AACTCCACCC AAGAGGCTGG GTTTCTAGGG 241 CCCAGAGCTG CCCTCCCCCA CCCTAGAATG GGCTATAAAA GTCCCTTCCC AGCTACGTCC 301 AGAGAAGAGC TGGAGGAAGT GAGAGGTCGG CTGGGGGTCC TCAAAGTGAG AGGGGAGCAG 361 AGGATCCTCC CGTGCAGGCT GTGGATGTCA CTCACTTCCC AGCTGGTGAA GCCTCGCTGC 421 AGAGATGCAT CTGCTCCCAG CCCTGGCAGG GGTCCTGGCC ACACTCGTCC TCGCCCAGCC 481 CTGTGAGGGC ACTGACCCAG GTAATAGTCC CCTAGACAGG CAAGGAGGAG GGAGGGGAAA 541 TGGAAGGGGA AGCACTTGGG TCTTGGAGGG GGTCTTGTGG CTTGCTGAAC CCTGAGTCCC 601 CATCTCTTTG AACAGCCTCC CCTGGGGCAG TGGAGACCTC GGTCCTGCGA GACTGCATAG 661 CAGAGGCCAA GTTGCTGGTG GATGCTGCCT ACAATTGGAC CCAGAAGAGG TGGACTTGGG 721 TCTGGGGGCT GCATGGGCCT GGGAGGATCA GT (2) INFORMATION FOR SEQ ID NO:2484: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 361 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2484: 1 TAATACCTTG TGGGGTCAGG GAGCCCATGT CCCGTGCTGA TGTTATTTCC CCACCAGGTC 61 CGGGCTGTCT CCAACCAGAT TGTGCGCTTC CCCAATGAGA GACTGACCTC CGACCGTGGC 121 CGAGCCCTCA TGTTCATGCA GTGGGGCCAG TTCATTGACC ATGACCTGGA CTTCTCCCCG 181 GAGTCCCCGG CCAGAGTGGC CTTCACTGCA GGCGTTGACT GTGAGAGGAC CTGCGCCCAG 241 CTGCCCCCCT GCTTTCCCAT CAAGGTACCT ACCCTCAGCC AATCTCCCAT GCCCTTGTGT 301 GGCCTCCCCC AAAGGCAAGG TGCTGGGGGT GGGGATCTGG AAGACTGGAG CACCATCCTT 361 AAGGAGCTGC CTGTGGAGCT AGGGTATGAG ACAGAGACAC AAG (2) INFORMATION FOR SEQ ID NO:2485: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 481 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2485: 1 CACTGTCTCC TCTTCCATCT CAGATCCCAC CCAATGACCC CCGCATCAAG AACCAGCGTG 61 ACTGCATCCC TTTCTTCCGC TCGGCACCCT CATGCCCCCA AAACAAGAAC AGAGTCCGCA 121 ACCAGATCAA CGCGCTCACC TCCTTTGTGG ACGCCAGCAT GGTGTATGGC AGTGAGGTCT 181 CCCTCTCGCT GCGGCTCCGC AACCGGACCA ACTACCTGGG GCTGCTGGCC ATCAACCAGC 241 GCTTTCAAGA CAACGGCCGG GCCCTGCTGC CCTTCGACAA CCTGCACGAT GACCCCTGTC 301 TCCTCACCAA CCGCTCGGCG CGCATCCCCT GCTTCCTGGC AGGTCAGACA GGGAGGAAGG 361 TGGTGTCTTC CCAGGAAACA GCCATCCCTG GGGTCCCAAC TGGGAAGCAA TGGTGGGATG 421 TGGTGAAGGT ACATGGTTTG GGACCTCAGT ATTAGGCACA CCATAAGCAT GGATCTGTGC 481 AC (2) INFORMATION FOR SEQ ID NO:2486: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 301 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2486: 1 TGAAGAGATG GAGGTCCAGT GAGGGCCAGG AGTTTGGCCC ACCCCGTCTC TCCCATCCCC WO 00/09525 PCTUS99/17712 EPI-109 647 61 AGCCCTGGGT CTACCCTGGT AGAAAGACAT TTCTCTGGGA AAGGCTSCAG TAAATCTGAG 121 CTTGGGGTTT TCAAGGTGAC ACCCGATCAA CGGAAACCCC CAAACTGGCA GCCATGCACA 181 CCCTCTTTAT GCGAGAGCAC AACCGGCTGG CCACCGAGCT GAGACGCCTG AATCCCCGGT 241 GGAATGGAGA CAAACTGTAC AATGAGGCTC GGAAGATCAT GGGGGCCATG GTCCAGGTAA 301 GGAGCTCTGC ATCCCAGCAT CCCCC (2) INFORMATION FOR SEQ ID NO:2487: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 421 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2487: 1 CTTTGTATCT CCACCCACCA ATAGTAAATT AATGTTGTCA CATTTGACGT GATGACAATA 61 AAGAATATGT CTGAGCCACC CTTTGAAAAG GCAAGGGTAT GGGTGAGTAG CCTCTGGGGA 121 ATGTTCCTCC TGTCTTCCCT TCCAGATCAT CACCTACCGA GACTTTCTGC CCCTGGTTCT 181 GGGCAAGGCC CGGGCCAGGA GAACCCTGGG GCACTACAGG GGGTACTGCT CCAATGTGGA 241 CCCACGGGTG GCCAATGTCT TCACCCTGGC CTTCCGCTTT GGCCACACAA TGCTCCAGCC 301 CTTCATGTTC CGCTTGGACA GTCAGTACCG GGCCTCCGCA CCCAACTCGC ATGTCCCACT 361 TAGCTCTGCC TTCTTTGCCA GCTGGCGGAT CGTGTATGAA GGTGACCAGG TTTTCCAGGG 421 GGCAAATGGG GGTGAGGGTG GGGAGCATGC CCTCCCCTAG GTGG (2) INFORMATION FOR SEQ ID NO:2488: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 361 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2488: 1 TCCAGCTGCT TCATGTCTCT CCAGAACTCT GTTTCCTGAC AAACGTTACT AACATACCCG 61 ACTGGCTTGT CCAGCTCTGG GCTAGCTTGG CATCATGTGA TAACCCAAGT AGCTTCCCAG 121 AGGCTGGTCC AATCTGTGCT GCTCACATTC CCTGCCACCA GGGGGCATCG ACCCCATCCT 181 CCGGGGCCTC ATGGCCACCC CTGCCAAGCT GAACCGTCAG GATGCCATGT TAGTGGATGA 241 GCTCCGGGAC CGGCTGTTTC GGCAAGTGAG GAGGATTGGG CTGGACCTGG CAGCTCTCAA 301 CATGCAACGA AGCCGGGACC ACGGCCTTCC AGGTGAGGGG GCTGTCCACC TCTTCTCCCA 361 GCTTTGCTCG GGCCAGGCTG CTCAAGGGGT TCTGGGAAGA CCCTGGTACC (2) INFORMATION FOR SEQ ID NO:2489: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 421 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear. (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2489: 1 CGACTGCCTG GTAGGTTCTG GTGGCAGAAA CGAGGTGTTT TCACCAAAAG ACAGCGCAAG 61 GCCCTGAGCA GAATTTCCTT GTCTCGAATT ATATGTGACA ATACCGGTAT CACCACGGTT 121 TCAAGGGACA TCTTCAGAGC CAACATCTAC CCTCGGGGCT TTGTGAACTG CAGCCGTATC 181 CCCAGGTTGA ACCTATCAGC CTGGCGAGGG ACATGAGGCT TCTGCAGGTA AGGGGAGGCC 241 ACCTCCAGCA CCCTGGGCTG GTTAAGCCTC ACATCCTTCC CTGGATGGAT GGCTGAGTCC 301 TCTTAGGTCT CTAAGCAGAG AAAACAGAAC TTGTCACTAG GTACTCTTTC CAAGTGGCTT 361 CCCAATGTGC TAGTTTCTGG GCTGACAGTC AATTCCAGGC CCTAGGACTT TGGGGGGAAA 421 TTAGGAGCAT CCAACTA (2) INFORMATION FOR SEQ ID NO:2490: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 2521 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2490: 1 GAATTCCGTG GCCAGGACCC CTGCCAGGGC ACTGACCCAG CCTCCCCTGG GGCAGTGGAG 61.ACCTCGGTCC TGCGAGACTG CATAGCAGAG GCCAAGTTGC TGGTGGATGC TGCCTACAAT 121 TGGACCCAGA AGAGCATCAA GCAGCGGCTT CGCAGCGGTT CAGCCAGCCC CATGGACCTC 181 CTGTCCTACT TCAAACAACC GGTAGCAGCC ACCAGGACAG TTGTTCGGGC CGCAGATTAT 241 ATGCATGTGG CTTTGGGGCT GCTTGAAGAG AAGTTACAAC CCCAGCGGTC CGGACCCTTC 301 ATTGTCACTG ATGTGCTAAC AGAACCACAG CTGCGGCTGC TGTCCCAGGC CAGTGGCTGT 361 GCTCTCCGGG ACCAGGCCGA GCGCTGCAGC GACAAGTACC GCACCATCAC TGGACGGTGC 421 AACAACAAGA GGAGACCCTT GCTAGGGGCC TCCAACCAGG CTCTGGCTCG CTGGCTGCCC 481 GCCGAGTATG AGGATGGGCT GTCGCTCCCC TTCGGCTGGA CCCCCAGCAG GAGGCGCAAT 541 GGCTTCCTTC TCCCTCTTGT CCGGGCTGTC TCCAACCAGA TTGTGCGCTT CCCCAATGAG WO 00/09525 PCT/US99/17712 EPI-109 648 601 AGACTGACCT CCGACCGTGG CCGAGCCCTC ATGTTCATGC AGTGGGGCCA GTTCATTGAC 661 CATGACCTGG ACTTCTCCCC GGAGTCCCCG GCCAGAGTGG CCTTCACTGC AGGCGTTGAC 721 TGTGAGAGGA CCTGCGCCCA GCTGCCCCCC TGCTTTCCCA TCAAGATCCC ACCCAATGAC 781 CCCCGCATCA AGAACCAGCG TGACTGCATC CCTTTCTTCC GCTCGGCACC CTCATGCCCC 841 CAAAACAAGA ACAGAGTCCG CAACCAGATC AACGCGCTCA CCTCCTTTGT GGACGCCAGC 901 ATGGTGTATG GCAGTGAGGT CTCCCTCTCG CTGCGGCTCC GCAACCGGAC CAACTACCTG 961 GGGCTGCTGG CCATCAACCA GCGCTTTCAA GACAACGGCC GGGCCCTGCT GCCCTTCGAC 1021 AACCTGCACG ATGACCCCTG TCTCCTCACC AACCGCTCGG CGCGCATCCC CTGCTTCCTG 1081 GCAGGTGACA CCCGATCAAC GGAAACCCCC AAACTGGCAG CCATGCACAC CCTCTTTATG 1141 CGAGAGCACA ACCGGCTGGC CACCGAGCTG AGACGCCTGA ATCCCCGGTG GAATGGAGAC 1201 AAACTGTACA ATGAGGCTCG GAAGATCATG GGGGCCATGG TCCAGATCAT CACCTACCGA 1261 GACTTTCTGC CCCTGGTTCT GGGCAAGGCC CGGGCCAGGA GAACCCTGGG GCACTACAGG 1321 GGGTACTGCT CCAATGTGGA CCCACGGGTG GCCAATGTCT TCACCCTGGC CTTCCGCTTT 1381 GGCCACACAA TGCTCCAGCC CTTCATGTTC CGCTTGGACA GTCAGTACCG GGCCTCCGCA 1441 CCCAACTCGC ATGTCCCACT TAGCTCTGCC TTCTTTGCCA GCTGGCGGAT CGTGTATGAA. 1501 GGGGGCATCG ACCCCATCCT CCGGGGCCTC ATGGCCACCC CTGCCAAGCT GAACCGTCAG 1561 GATGCCATGT TAGTGGATGA GCTCCGGGAC CGGCTGTTTC GGCAAGTGAG GAGGATTGGG 1621 CTGGACCTGG CAGCTCTCAA CATGCAACGA AGCCGGGACC ACGGCCTTCC AGGGTACAAT 1681 GCTTGGAGGC GCTTCTGTGG GCTCTCCCAG CCCCGGAATT TGGCACAGCT TAGCCGGGTG 1741 CTGAAAAACC AGGACTTGGC AAGGAAGTTC CTGAATTTGT ATGGAACACC TGACAACATT 1801 GACATCTGGA TTGGGGCCAT CGCTGAGCCT CTTTTGCCGG GGGCTCGAGT GGGGCCTCTT 1861 CTGGCTTGTC TGTTCGAGAA CCAGTTCAGA AGAGCCGAGA CGGAGACAGG TTCTGGTGGC 1921 AGAACGAGGT GTTTTCACCA AAGACAGCGC AAGGCCCTGA GCAGAATTTC CTTGTCTCGA 1981 ATTATATGTG ACAATACCGG TATCACCACG GTTTCAAGGG ACATCTTCAG AGCCAACATC 2041 TACCCTCGGG GCTTTGTGAA CTGCAGCCGT ATCCCCAGGT TGAACCTATC AGCCTGGCGA 2101 GGGACATGAG GCTTCTGCAG GAGTCTATCC CAAGTCTCCA ACTTTTGGAG ACAAGGGGAA 2161 GGGGAGGACC ATGAGGCTGC CTTGTCTCCC TGGAGCAAGT GCAGGCTCGT GACGCTTCTG 2221 CTGGCTACAG CTCAGAGCTG GGTTCCCCAG CCAGGAGTGA AGGCTGGGGG CTCCTATCAG 2281 CAATGGACCT TCCGCCTTGG GAGCCTCTTA GGTATTAGGC TATGAATCAG CGCCACGTGC 2341 AAAGGCTTGG GAGCCAAGCC ATGTGGTCTT GCACCCCAGG CAAGAAAAGT CAGCTGGAGG 2401 GTTTACAGCA CTTTCTACTG TTTCCCAGCC CTCCCTCCCC TCCCTCACCA TGACTAAGAG 2461 ACCACTCGGT CCTAGCCTCC AGACACCCCA CAATACTCCT CTGAGCCTGA GGCCAGGCAG 2521 CATGCTCTGC TTCTACCAAT AAAGCACTGC CGGAATTC (2) INFORMATION FOR SEQ ID NO:2491: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 2581 base pairs (H) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2491: (2) INFORMATION FOR SEQ ID NO:2492: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 781 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2431: 1 GCATTTTTTC AAGTTTTATG ATTTATTTAA CTTGTGGAAC AAAAATAAAC CAGAAACCAC 61 CACCTCTCAC GCCAAAGCTC ACACCTTCAG CCTCCAACAT GAAGGTCTCC GCAGCACTTC 121 TGTGGCTGCT GCTCATAGCA GCTGCCTTCA GCCCCCAGGG GCTCGCTGGG CCAGCTTCTG 181 TCCCAACCAC CTGCTGCTTT AACCTGGCCA ATAGGAAGAT ACCCCTTCAG CGACTAGAGA 241 GCTACAGGAG AATCACCAGT GGCAAATGTC CCCAGAAAGC TGTGATCTTC AAGACCAAAC 301 TGGCCAAGGA TATCTGTGCC GACCCCAAGA AGAAGTGGGT GCAGGATTCC ATGAAGTATC 361 TGGACCAAAA ATCTCCAACT CCAAAGCCAT AAATAATCAC CATTTTTGAA ACCAAACCAG 421 AGCCTGAGTG TTGCCTAATT TGTTTTCCCT TCTTACAATG CATTCTGAGG TAACCTCATT 481 ATCAGTCCAA AGGGCATGGG TTTTATTATA TATATATATA TTTTTTTTTT AAAAAAAAAC 541 GTATTGCATT TAATTTATTG AGGCTTTAAA ACTTATCCTC CATGAATATC AGTTATTTTT 601, AAACTGTAAA GCTTTGTGCA GATTCTTTAC CCCCTGGGAG CCCCAATTCG ATCCCCTGTC 661 ACGTGTGGGC AATGTTCCCC CTCTCCTCTC TTCCTCCCTG GAATCTTGTA AAGGTCCTGG 721 CAAAGATGAT CAGTATGAAA ATGTCATTGT TCTTGTGAAC CCAAAGTGTG ACTCATTAAA 781 TGGAAGTAAA TGTTGTTTTA GGAATAC (2) INFORMATION FOR SEQ ID NO:2492: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 241 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single WO 00/09525 PCT/US99/17712 EPI-109 649 (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2492: 1 ATGAAGGTCT CCGCAGCACT TCTGTGGCTG CTGCTCATAG CAGCTGCCTT CAGCCCCCAG 61 GGGCTCGCTG GGCCAGCTTC TGTCCCAACC ACCTGCTGCT TTAACCTGGC CAATAGGAAG 121 ATACCCCTTC AGCGACTAGA GAGCTACAGG AGAATCACCA GTGGCAAATG TCCCCAGAAA 181 GCTGTGATCT TCAAGACCAA ACTGGCCAAG GATATCTGTG CCGACCCCAA GAAGAAGTGG 241 GTGCAGGATT CCATGAAGTA TCTGGACCAA AAATCTCCAA CTCCAAAGCC ATAA (2) INFORMATION FOR SEQ ID NO:2493: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: base pairs (B) TYPE: 2641 nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2493: 1 CCACATATTC CCCTCCTTTT CCAAGGCAAG ATCCAGATGG ATTAAAAAAT GTACCAAGTC 61 CCTCCTACTA GCTTGCCTCT CTTCTGTTCT GCTTGACTTC CTAGGATCTG GAATCTGGTC 121 AGCAATCAGG AATCCCTTCA TCGTGACCCC CGCATGGGCA AAGGCTTCCC TGGAATCTCC 181 CACACTGTCT GCTCCCTATA AAAGGCAGGC AGATGGGCCA GAGGACCAGA GAGGCTGAGA 241 CCAACCCAGA AACCACCACC TCTCACGCCA AAGCTCACAC CTTCAGCCTC CAACATGAAG 301 GTCTCCGCAG CACTTCTGTG GCTGCTGCTC ATAGCAGCTG CCTTCAGCCC CCAGGGGCTC 361 GCTGGGCCAG GTAAGCCCCC CAACTCCTTA CAGGAAAGGT AAGGTAACCA CCTCCAGGCT 421 ACTAGGTCAG CAAGAATCTT TACAGACTCA CTGCAAATTC TCCATTTGAA AAATAGGGAA 481 ACAGGTTTTG TGGGTGGACA AGAAATGCCT CAACCGTCAC ATCCAGTCAC TGGAAGAGCC 541 AGAACTAGAA AGCTCCCSAG TCTTTTCCCC ACATTCAAGA GGGCCGCTGG GTGCATCCTT 601 ACCCAGCTAT CCTTACAGTG TTTGGGAATG GGGAATGGCT CTGTCTTACT GTGGGCATGG 661 TGGGCATTTT TGGCAGTGGG AGAGAAGGAA AATCTGTTGA TTAGAAGCTC AGTATGTTAA 721 TTCGACTCCA GGACAGCTTT CAGAGACAGT GGCTAAGAGA AGAACGAGGT CCCAGGGGAT 781 CTCTTGAGGT GACTTATTTT GACACTCTTT GGGAAAGTTA TCTAGGAGAT TTGTTCCATA 841 ACTCATTTTC CCATACTCTG GTGACAAATT TACTGAGTGT ATCGGTCCCA CTGAGCCAGT 901 GCATAGCATG GTAACAAACA GTTCTAAATT ATCAATGACT TAACAGAATT AACTAAATTA 961 ACAAAAGTTA CTTTCTCACT TGTACTAAAT ATCTATAATG TATGGGCTCA GGCTTCTGCA 1021 TTTTATACTC AGGATTCTAG ACTGATGGAG AAGTTGCCAT GTGGGGGAAC ATTGATGGAT 1081 ACTGTGATAA AGCAGAAGAA AGCTCTCAGG AGTCTTGCAT AGGCAATGCA CTGTGGCTCA 1141 AAAATGACAC CCATCACTTT GTCTCCTTCT TTATTGATCA AAACTAATTA ATGCCTCCAA 1201 CCAAACAAAA GTGGCCAAGA AATGCAAGTC TACCTTGTGT CTCAAAACAG AGGATGGAGA 1261 ATATTTGGTG AAAATTACCA TGACCATCAC ATGGCCACGT AGGTCTTTAT AATGACAGAG 1321 CTAGCATTTG TCACATTGAC CAAGCTTTGT CCATACACTC TACAGTAATG ATGAGTCCTC 1381 AGTGCACAGG GGAGGATGCT GAAGACACAG GACAGCATCC TCCAGACACA TAAGACTTCA 1441 GAGCAGAGGG ATTCTCCCTC CACCTCTCGC AATTCCTTGC TTTCTCCTAA CTTCCTTTAC 1501 AAAGTCATGC TTGGAAATGT CTATGTATCA TCATGTGGCT CATTTTTTTC TCTGTTCATT 1561 TTTTTTCCCC AAAATTCAGC TTCTGTCCCA ACCACCTGCT GCTTTAACCT GGCCAATAGG 1621 AAGATACCCC TTCAGCGACT AGAGAGCTAC AGGAGAATCA CCAGTGGCAA ATGTCCCCAG 1681 AAAGCTGTGA TGTAAGTAAA TAAAGTTCAC CCTCCCCTAG ACAAAAAAAT AATGTCTAGG 1741 GCACAGAGTC AAGAACTGTG GGAGTCATAG ACTCTGATAG TTTGACCTCT ATGGTCCAAT 1801 TCATTAATTT TCACAAGTGA GTGTTCACTC CCAGCTCCCT GCCTGGGAGA TTGCTGTAGT 1861 CATATCAATT TCTTCAAGTC AAGAGCAAAG ATGGTTTTAC TGGGCCTTTA AGAGCAGCAA 1921 CTAACCCAAG AGTCTCATCC TTCCTCCTCT CCGTAGCAAC CCTTTGTCCA GGGGCAGATG 1981 GTCCTTAAAT ATTTAGGGTC AAATGGGCAG AATTTTCAAA AACAATCCTT CCAATTGCAT 2041 CCTGATTCTC CCCACAGCTT CAAGACCAAA CTGGCCAAGG ATATCTGTGC CGACCCCAAG 2101 AAGAAGTGGG TGCAGGATTC CATGAAGTAT CTGGACCAAA AATCTCCAAC TCCAAAGCCA 2161 TAAATAATCA CCATTTTTGA AACCAAACCA GAGCCTGAGT GTTGCCTAAT TTGTTTTCCC 2221 TTCTTACAAT GCATTCTGAG GTAACCTCAT TATCAGTCCA AAGGGCATGG GTTTTATTAT 2281 ATATATATAT ATATATTTTT TTTTAAAAAA AAACGTATTG CATTTAATTT ATTGAGGCTT 2341 TAAAACTTAT CCTCCATGAA TATCAGTTAT TTTTAAACTG TAAAGCTTTG TGCAGATTCT 2401 TTACCCCCTG GGAGCCCCAA TTCGATCCCC TGTCACGTGT GGGCAATGTT CCCCCTCTCC 2461 TCTCTTCCTC CCTGGAATCT TGTAAAGGTC CTGGCAAAGA TGATCAGTAT GAAAATGTCA 2521 TTGTTCTTGT GAACCCAAAG TGTGACTCAT TAAATGGAAG TAATGTTGTT TTAGGAATAC 2581 ATAAAGTATG TGCATATTTT ATTATAGTCA CTAGTTGTAA TTTTTTTGTG GGAAATCCAC 2641 ACTGAGCTGA GGGGG (2) INFORMATION FOR SEQ ID NO:2494: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 3663 base pairs (B) TYPE: 2641 nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2494: 1 GCATTTTTTC AAGTTTTATG ATTTATTTAA CTTGTGGAAC AAAAATAAAC CAGAAACCAC WO 00/09525 PCT/US99/17712 EPI-109 650 61 CACCTCTCAC GCCAAACCTC ACACCTTCAG CCTCCAACAT GAAGGTCTCC GCAGCACTTC 121 TGTGGCTGCT GCTCATAGCA CCTGCCTTCA GCCCCCAGGG GCTCGCTGGG CCAGCTTCTG 181 TCCCAACCAC CTGCTGCTTT AACCTGGCCA ATAGGAAGAT ACCCCTTCAG CGACTAGAGA 241 GOTACAGGAG AATCACCAGT GGCAAATGTC CCCAGAAAGC TGTGATCTTC AAGACCAAAC 301 TGGCCAAGGA TATCTGTGCC GACCCCAAGA AGAAGTGGGT GCAGGATTCC ATGAAGTATC 361 TGGACCAAAA ATCTCCAACT CCAAAGCCAT AAATAATCAC CATTTTTGAA ACCAAACCAG 421 AGCCTGAGTG TTGCCTAATT TGTTTTCCCT TCTTACAATG CATTCTGAGG TAACCTCATT 481 ATCAGTCCAA AGGGCATGGG TTTTATTATA TATATATATA TTTTTTTTTT AAAAAAAAAC 541 GTATTGCATT TAATTTATTG AGGCTTTAAA ACTTATCCTC CATGAATATC AGTTATTTTT 601 ZAAACTGTAAA GCTTTGTGCA GATTCTTTAC CCCCTGGGAG CCCCAATTCG ATCCCCTGTC 661 ACGTGTGGGC AATGTTCCCC CTCTCCTCTC TTCCTCCCTG GAATCTTGTA AAGGTCCTGG 721 CAAAGATGAT CAGTATGAAA ATGTCATTGT TCTTGTGAAC CCAAAGTGTG ACTCATTAAA 781 TGGAAGTAAA TGTTGTTTTA GGAATACATG AAGGTCT CCGCAGCACT TCTGTGGCTG 801 CTGCTCATAG CAGCTGCCTT CAGCCCCCAG GGGCTCGCTG GGCCAGCTTC TGTCCCAACC 861 ACCTGCTGCT TTAACCTGGC CAATAGGAAG ATACCCCTTC AGCGACTAGA GAGCTACAGG 921 AGAATCACCA GTGGCAAATG TCCCCAGAAA GCTGTGATCT TCAAGACCAA ACTGGCCAAG 981 GATATCTGTG CCGACCCCAA GAAGAAGTGG GTGCAGGATT CCATGAAGTA TCTGGACCAA 1005 AAATCTCCAA CTCCAAAGCC ATAA 1065 CCACATATTC CCCTCCTTTT CCAAGGCAAG ATCCAGATGG ATTAAAAAAT GTACCAAGTC 1121 CCTCCTACTA GCTTGCCTCT CTTCTGTTCT GCTTGACTTC CTAGGATCTG GAATCTGGTC 1181 AGCAATCAGG AATCCCTTCA TCGTGACCCC CGCATGGGCA AAGGCTTCCC TGGAATCTCC 1241 CACACTGTCT GCTCCCTATA AAAGGCAGGC AGATGGGCCA GAGGAGCAGA GAGGCTGAGA 1301 CCAACCCAGA AACCACCACC TCTCACGCCA AAGCTCACAC CTTCAGCCTC CAACATGAAG 1361 GTCTCCGCAG CACTTCTGTG GCTGCTGCTC ATAGCAGCTG CCTTCAGCCC CCAGGGGCTC 1421 GCTGGGCCAG GTAAGCCCCC CAACTCCTTA CAGGAAAGGT AAGGTAACCA CCTCCAGGCT 1481 ACTAGGTCAG CAAGAATCTT TACAGACTCA CTGCAAATTC TCCATTTGAA AAATAGGGAA 1541 ACAGGTTTTG TGGGTGGACA AGAAATGCCT CAACCGTCAC ATCCAGTCAC TGGAAGAGCC 1601 AGAACTAGAA AGCTCCCGAG TCTTTTCCCC ACATTCAAGA GGGCCGCTGG GTGCATCCTT 1661 ACCCAGCTAT CCTTACAGTG TTTGGGAATG GGGAATGGCT CTGTCTTACT GTGGGCATGG 1721 TGGGCATTTT TGGCAGTGGG AGAGAAGGAA AATCTGTTGA TTAGAAGCTC AGTATGTTAA 1781 TTCGACTCCA GGACAGCTTT CAGAGACAGT GGCTAAGAGA AGAACGAGGT CCCAGGGGAT 1841 CTCTTGAGGT GACTTATTTT GACACTCTTT GGGAAAGTTA TCTAGGAGAT TTGTTCCATA 1901 ACTCATTTTC CCATACTCTG GTGACAAATT TACTGAGTGT ATCGGTCCCA CTGAGCCAGT 1961 GCATAGCATG GTAACAAACA GTTCTAAATT ATCAATGACT TAACAGAATT AACTAAATTA 2021 ACAAAAGTTA CTTTCTCACT TGTACTAAAT ATCTATAATG TATGGGCTCA GGCTTCTGCA 2081 TTTTATACTC AGGATTCTAG ACTGATGGAG AAGTTGCCAT GTGGGGGAAC ATTGATGGAT 2141 ACTGTGATAA AGCAGAAGAA AGCTCTCAGG AGTCTTGCAT AGGCAATGCA CTGTGGCTCA 2201 AAAATGACAC CCATCACTTT GTCTCCTTCT TTATTGATCA AAACTAATTA ATGCCTCCAA 2261 CCAAACAAAA GTGGCCAAGA AATGCAAGTC TACCTTGTGT CTCAAAACAG AGGATGGAGA 2321 ATATTTGGTG AAAATTACCA TGACCATCAC ATGGCCACGT AGGTCTTTAT AATGACAGAG 2381 CTAGCATTTG TCACATTGAC CAAGCTTTGT CCATACACTC TACAGTAATG ATGAGTCCTC 2441 AGTGCACAGG GGAGGATGCT GAAGACACAG GACAGCATCC TCCAGACACA TAAGACTTCA 2501 GAGCAGAGGG ATTCTCCCTC CACCTCTCGC AATTCCTTGC TTTCTCCTAA. CTTCCTTTAC 2561 AAAGTCATGC TTGGAAATGT CTATGTATCA TCATGTGGCT CATTTTTTTC TCTGTTCATT 2621 TTTTTTCCCC AAAATTCAGC TTCTGTCCCA ACCACCTGCT GCTTTAACCT GGCCAATAGG 2681 AAGATACCCC TTCAGCGACT AGAGAGCTAC AGGAGAATCA CCAGTGGCAA ATGTCCCCAG 2741 AAAGCTGTGA TGTAAGTAAA TAAAGTTCAC CCTCCCCTAG ACAAAAAAAT AATGTCTAGG 2801 GCACAGAGTC AAGAACTGTG GGAGTCATAG ACTCTGATAG TTTGACCTCT ATGGTCCAAT 2861 TCATTAATTT TCACAAGTGA GTGTTCACTC CCAGCTCCCT GCCTGGGAGA TTGCTGTAGT 2921 CATATCAATT TCTTCAAGTC AAGAGCAAAG ATGGTTTTAC TGGGCCTTTA AGAGCAGCAA 2981 CTAACCCAAG AGTCTCATCC TTCCTCCTCT CCGTAGCAAC CCTTTGTCCA GGGGCAGATG 3041 GTCCTTAAAT ATTTAGGGTC AAATGGGCAG AATTTTCAAA. AACAATCCTT CCAATTGCAT 3101 CCTGATTCTC CCCACAGCTT CAAGACCAAA CTGGCCAAGG ATATCTGTGC CGACCCCAAG 3161 AAGAAGTGGG TGCAGGATTC CATGAAGTAT CTGGACCAAA AATCTCCAAC TCCAAAGCCA 3221 TAAATAATCA CCATTTTTGA AACCAAACCA GAGCCTGAGT GTTGCCTAAT TTGTTTTCCC 3281 TTCTTACAAT GCATTCTGAG GTAACCTCAT TATCAGTCCA AAGGGCATGG GTTTTATTAT 3341 ATATATATAT ATATATTTTT TTTTAAAAAA AAACGTATTG CATTTAATTT ATTGAGGCTT 2341 TAAAACTTAT CCTCCATGAA TATCAGTTAT TTTTAAACTG TAAAGCTTTG TGCAGATTCT 2401 TTACCCCCTG GGAGCCCCAA TTCGATCCCC TGTCACGTGT GGGCAATGTT CCCCCTCTCC 2461 TCTCTTCCTC CCTGGAATCT TGTAAAGGTC CTGGCAAAGA TGATCAGTAT GAAAATGTCA 2521 TTGTTCTTGT GAACCCAAAG TGTGACTCAT TAAATGGAAG TAATGTTGTT TTAGGAATAC 2581 ATAAAGTATG TGCATATTTT ATTATAGTCA CTAGTTGTAA TTTTTTTGTG GGAAATCCAC 2641 ACTGAGCTGA GGGGG (2) INFORMATION FOR SEQ ID NO:2495: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 61 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single WO 00/09525 PCT/US99/17712 EPI-109 651 (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2495: 1 GCCAGGTCGC TGTTGGTCCA CGCCGCCCGT CGCGCCGCCC GCCCGCTCAG CGTCCGCCGC 61 CGCCATGGGA (2) INFORMATION FOR SEQ ID NO:2496: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 841 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2496: 1 GGCCGGAGCC GAGCCGGGGT CGGGCAGCAG CAGGGACCCC CCAGAGGCGG GGCCTGTGGG 61 ACCGCTATGG GCGTGGAGAT CGAGACCATC TCCCCCGGAG ACGGAAGGAC ATTCCCCAAG 121 AAGGGCCAAA CGTGTGTGGT GCACTACACA GGAATGCTCC AAAATGGGAA GAAGTTTGAT 181 TCATCCAGAG ACAGAAACAA ACCTTTCAAG TTCAGAATTG GCAAACAGGA AGTCATCAAA 241 GGTTTTGAAG AGGGTGCAGC CCAGATGAGC TTGGGGCAGA GGGCGAAGCT GACCTGCACC 301 CCTGATGTGG CATATGGAGC CACGGGCCAC CCCGGTGTCA TCCCTCCCAA TGCCACCCTC 361 ATCTTTGACG TGGAGCTGCT CAACTTAGAG TGAAGGCAGG AAGGAACTCA AGGTGGCTGG 421 AGATGGCTGC TGCTCACCCT CCTAGCCTGC TCTGCCACTG GGACGGCTCC TGCTTTTGGG 481 GCTCTTGATC AGTGTGCTAA CCTCACTGCC TCATGGCATC ATCCATTCTC TCTGCCCAAG 541 TTGCTCTGTA TGTGTTCGTC AGTGTTCATG CGAATTCTTG CTTGAGGAAA CTTCGGTTGC 601 AGATTGAAGC ATTTCAGGTT GTGCATTTTG TGTGATGCAT GTAGTAGCCT TTCCTGATGA 661 CAGAACACAG ATCTCTTGTT CGCACAATCT ACACTGCCTT ACCTTCACTT AAACCACACA 721 CACAAGGTGC TCAGACATGA AATGTACATG GCGTACCGTA CACAGAGGGA CTTGAGCCAG 781 TTACCTTTGC TGTCACTTTC TCTCTTATAA ATTCTGTTAG CTGCTCACTT AAACAATGTC 841 CTCTTTGAGA AAATGTAAAA TAAAGGCTCT GTGCTTGACA (2) INFORMATION FOR SEQ ID NO:2497: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1501 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2497: 1 GAATTCGGGC CGCCGCCAGG TCGCTGTTGG TCCACGCCGC CCGTCGCGCC GCCCGCCCGC 61 TCAGCGTCCG CCGCCGCCAT GGGAGTGCAG GTGGAAACCA TCTCCCCAGG AGACGGGCGC 121 ACCTTCCCCA AGCGCGGCCA GACCTGCGTG GTGCACTACA CCGGGATGCT TGAAGATGGA 181 AAGAAATTTG ATTCCTCCCG GGACAGAAAC AAGCCCTTTA AGTTTATGCT AGGCAAGCAG 241 GAGGTGATCC GAGGCTGGGA AGAAGGGGTT GCCCAGATGA GTGTGGGTCA GAGAGCCAAA 301 CTGACTATAT CTCCAGATTA TGCCTATGGT GCCACTGGGC ACCCAGGCAT CATCCCACCA 361 CATGCCACTC TCGTCTTCGA TGTGGAGCTT CTAAAACTGG AATGACAGGA ATGGCCTCCT 421 CCCTTAGCTC CCTGTTCTTG GATCTGCCAT GGAGGGATCT GGTGCCTCCA GACATGTGCA 481 CATGAGTCCA TATGGAGCTT TTCCTGATGT TCCACTCCAC TTTGTATAGA CATCTGCCCT 541 GACTGAATGT GTTCTGTCAC TCAGCTTTGC TTCCGACACC TCTGTTTCCT CTTCCCCTTT 601 CTCCTCGTAT GTGTGTTTAC CTAAACTATA TGCCATAAAC CTCAAGTTAT TCATTTTATT 661 TTGTTTTCAT TTTGGGGTGA AGATTCAGTT TCAGTCTTTT GGATATAGGT TTCCAATTAA 721 GTACATGGTC AAGTATTAAC AGCACAAGTG GTAGGTTAAC ATTAGAATAG GAATTGGTGT 781 TGGGGGGGGG GTTTGCAAGA ATATTTTATT TTAATTTTTT GGATGAAATT TTTATCTATT 841 ATATATTAAA CATTCTTGCT GCTGCGCTGC AAAGCCATAG CAGATTTGAG GCGCTGTTGA 901 GGACTGAATT ACTCTCCAAG TTGAGAGATG TCTTTGGGTT AAATTAAAAG CCCTACCTAA 961 AACTGAGGTG GGGATGGGGA GAGCCTTTGC CTCCACCATT CCCACCCACC CTCCCCTTAA 1021 ACCCTCTGCC TTTGAAAGTA GATCATGTTC ACTGCAATGC TGGACACTAC AGGTATCTGT 1081 CCCTGGGCCA GCAGGGACCT CTGAAGCCTT CTTTGTGGCC TTTTTTTTTT TTCATCCTGT 1141 GGTTTTTCTA ATGGACTTTC AGGAATTTTG TAATCTCATA ACTTTCCAAG CTCCACCACT 1201 TCCTAAATCT TAAGAACTTT AATTGACAGT TTCAATTGAA GGTGCTGTTT GTAGACTTAA 1261 CACCCAGTGA AAGCCCAGCC ATCATGACAA ATCCTTGAAT GTTCTCTTAA GAAAATGATG 1321 CTGGTCATCG CAGCTTCAGC ATCTCCTGTT TTTTGATGCT TGGCTCCCTC TGCTGATCTC 1381 AGTTTCCTGG CTTTTCCTCC CTCAGCCCCT TCTCACCCCT TTGCTGTCCT GTGTAGTGAT 1441 TTGGTGAGAA ATCGTTGCTG CACCCTTCCC CCAGCACCAT TTATGAGTCT CAAGTTTTAT 1501CCTATTGCAATA AAAGTGCTTT ATGCCCGAAT TC (2) INFORMATION FOR SEQ ID NO:2498: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 541 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2498: 1 GCCGCCGCCA TGGGAGTGCA GGTGGAAACC ATCTCCCCAG GAGACGGGCG CACCTTCCCC WO 00/09525 PCT/US99/17712 EPI-109 652 61 AAGCGCGGCC AGACCTGCGT GGTGCACTAC ACCGGGATGC TTGAAGATGG AAAGAAATTT 121 GATTCCTCCC GGGACAGAAA CAAGCCCTTT AAGTTTATGC TAGGCAAGCA GGAGGTGATC 181 CGAGGCTGGG AAGAAGGGGT TGCCCAGATG AGTGTGGGTC AGAGAGCCAA ACTGACTATA 241 TCTCCAGATT ATGCCTATGG TGCCACTGGG CACCCAGGCA TCATCCCACC ACATGCCACT 301 CTCGTCTTCG ATGTGGAGCT TCTAAAACTG GAATGACAGG AATGGCCTCC TCCCTTAGCT 361 CCCTGTTCTT GGATCTGCCR TGGAGGGATC TGGTGCCTCC AGACATGTGC ACATGARTCC 421 ATATGGAGCT TTTCCTGATG TTCCACTCCA CTTTGTATAG ACATCTGCCC TGACTGAATG 481 TGTTCTGTCA CTCAGCTTTG CTTCCGACAC CTCTGTTTCC TCTTCCCCTT TCTCCTCGTA 541 TGTGTGTTTA CCTAAACTAT ATGCCATAAA CCTCAAGTTA TTCA (2) INFORMATION FOR SEQ ID NO:2499: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 3135 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2499: 1 GCCAGGTCGC TGTTGGTCCA CGCCGCCCGT CGCGCCGCCC GCCCGCTCAG CGTCCGCCGC 61 CGCCATGGGA GGCCGGAGCC GAGCCGGGGT CGGGCAGCAG CAGGGACCCC CCAGAGGCGG 121 GGCCTGTGGG ACCGCTATGG GCGTGGAGAT CGAGACCATC TCCCCCGGAG ACGGAAGGAC 181 ATTCCCCAAG AAGGGCCAAA CGTGTGTGGT GCACTACACA GGAATGCTCC AAAATGGGAA 241 GAAGTTTGAT TCATCCAGAG ACAGAAACAA ACCTTTCAAG TTCAGAATTG GCAAACAGGA 301 AGTCATCAAA GGTTTTGAAG AGGGTGCAGC CCAGATGAGC TTGGGGCAGA GGGCGAAGCT 361 GACCTGCACC CCTGATGTGG CATATGGAGC CACGGGCCAC CCCGGTGTCA TCCCTCCCAA 421 TGCCACCCTC ATCTTTGACG TGGAGCTGCT CAACTTAGAG TGAAGGCAGG AAGGAACTCA 481 AGGTGGCTGG AGATGGCTGC TGCTCACCCT CCTAGCCTGC TCTGCCACTG GGACGGCTCC 541 TGCTTTTGGG GCTCTTGATC AGTGTGCTAA CCTCACTGCC TCATGGCATC ATCCATTCTC 601 TCTGCCCAAG TTGCTCTGTA TGTGTTCGTC AGTGTTCATG CGAATTCTTG CTTGAGGAAA 661 CTTCGGTTGC AGATTGAAGC ATTTCAGGTT GTGCATTTTG TGTGATGCAT GTAGTAGCCT 721 TTCCTGATGA CAGAACACAG ATCTCTTGTT CGCACAATCT ACACTGCCTT ACCTTCACTT 781 AAACCACACA CACAAGGTGC TCAGACATGA AATGTACATG GCGTACCGTA CACAGAGGGA 841 CTTGAGCCAG TTACCTTTGC TGTCACTTTC TCTCTTATAA ATTCTGTTAG CTGCTCACTT 901 AAACAATGTC CTCTTTGAGA AAATGTAAAA TAAAGGCTCT GTGCTTGACA GAATTCGGGC 961 CGCCGCCAGG TCGCTGTTGG TCCACGCCGC CCGTCGCGCC GCCCGCCCGC 1011 TCAGCGTCCG CCGCCGCCAT GGGAGTGCAG GTGGAAACCA TCTCCCCAGG AGACGGGCGC 1171 ACCTTCCCCA AGCGCGGCCA GACCTGCGTG GTGCACTACA CCGGGATGCT TGAAGATGGA 1231 AAGAAATTTG ATTCCTCCCG GGACAGAAAC AAGCCCTTTA AGTTTATGCT AGGCAAGCAG 1291 GAGGTGATCC GAGGCTGGGA AGAAGGGGTT GCCCAGATGA GTGTGGGTCA GAGAGCCAAA 1351 CTGACTATAT CTCCAGATTA TGCCTATGGT GCCACTGGGC ACCCAGGCAT CATCCCACCA 1411 CATGCCACTC TCGTCTTCGA TGTGGAGCTT CTAAAACTGG AATGACAGGA ATGGCCTCCT 1471 CCCTTAGCTC CCTGTTCTTG GATCTGCCAT GGAGGGATCT GGTGCCTCCA GACATGTGCA 1531 CATGAGTCCA TATGGAGCTT TTCCTGATGT TCCACTCCAC TTTGTATAGA CATCTGCCCT 1591 GACTGAATGT GTTCTGTCAC TCAGCTTTGC TTCCGACACC TCTGTTTCCT CTTCCCCTTT 1651 CTCCTCGTAT GTGTGTTTAC CTAAACTATA TGCCATAAAC CTCAAGTTAT TCATTTTATT 1711 TTGTTTTCAT TTTGGGGTGA AGATTCAGTT TCAGTCTTTT GGATATAGGT TTCCAATTAA 1771 GTACATGGTC AAGTATTAAC AGCACAAGTG GTAGGTTAAC ATTAGAATAG GAATTGGTGT 1831 TGGGGGGGGG GTTTGCAAGA ATATTTTATT TTAATTTTTT GGATGAAATT TTTATCTATT 1891 ATATATTAAA CATTCTTGCT GCTGCGCTGC AAAGCCATAG CAGATTTGAG GCGCTGTTGA 1951 GGACTGAATT ACTCTCCAAG TTGAGAGATG TCTTTGGGTT AAATTAAAAG CCCTACCTAA 2011 AACTGAGGTG GGGATGGGGA GAGCCTTTGC CTCCACCATT CCCACCCACC CTCCCCTTAA 2071 ACCCTCTGCC TTTGAAAGTA GATCATGTTC ACTGCAATGC TGGACACTAC AGGTATCTGT 2131 CCCTGGGCCA GCAGGGACCT CTGAAGCCTT CTTTGTGGCC TTTTTTTTTT TTCATCCTGT 2191 GGTTTTTCTA ATGGACTTTC AGGAATTTTG TAATCTCATA ACTTTCCAAG CTCCACCACT 2251 TCCTAAATCT TAAGAACTTT AATTGACAGT TTCAATTGAA GGTGCTGTTT GTAGACTTAA 2331 CACCCAGTGA AAGCCCAGCC ATCATGACAA ATCCTTGAAT GTTCTCTTAA GAAAATGATG 2391 CTGGTCATCG CAGCTTCAGC ATCTCCTGTT TTTTGATGCT TGGCTCCCTC TGCTGATCTC 2451 AGTTTCCTGG CTTTTCCTCC CTCAGCCCCT TCTCACCCCT TTGCTGTCCT GTGTAGTGAT 2511 TTGGTGAGAA ATCGTTGCTG CACCCTTCCC CCAGCACCAT TTATGAGTCT CAAGTTTTAT 2561 TATTGCAATA AAAGTGCTTT ATGCCCGAAT TC 2594 GCCGCCGCCA TGGGAGTGCA GGTGGAAACC ATCTCCCCAG GAGACGGGCG CACCTTCCCC 2655 AAGCGCGGCC AGACCTGCGT GGTGCACTAC ACCGGGATGC TTGAAGATGG AAAGAAATTT 2715 GATTCCTCCC GGGACAGAAA CAAGCCCTTT AAGTTTATGC TAGGCAAGCA GGAGGTGATC 2775 CGAGGCTGGG AAGAAGGGGT TGCCCAGATG AGTGTGGGTC AGAGAGCCAA ACTGACTATA 2835 TCTCCAGATT ATGCCTATGG TGCCACTGGG CACCCAGGCA TCATCCCACC ACATGCCACT 2895 CTCGTCTTCG ATGTGGAGCT TCTAAAACTG GAATGACAGG AATGGCCTCC TCCCTTAGCT 2955 CCCTGTTCTT GGATCTGCCR TGGAGGGATC TGGTGCCTCC AGACATGTGC ACATGARTCC 3015 ATATGGAGCT TTTCCTGATG TTCCACTCCA CTTTGTATAG ACATCTGCCC TGACTGAATG 3075 TGTTCTGTCA CTCAGCTTTG CTTCCGACAC CTCTGTTTCC TCTTCCCCTT TCTCCTCGTA 3135 TGTGTGTTTA CCTAAACTAT ATGCCATAAA CCTCAAGTTA TTCA WO 00/09525 PCTIUS99/17712 EPI-109 653 (2) INFORMATION FOR SEQ :D NO:2500: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 7621 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2500: 1 AACAAGAAAA GCGTTGGTAG CTCTGGTGAA TCCCAAAAGA ATGTGGCAGT TGCTAGCCAT 61 GCTCCTGAAT ATGTATAAAC AGTACATCAT ATGACTAAGA GTTTGACTTA GGGGTTAGAT 121 TTTATGTGTT TGAACCCCAA ATTAGTTATT TAATAGTTGG CACCCCAAAA CAAGTTACTT 181 AACCTCACTA AGGTTCAGTT TTCCTGTTTA TAAAATGTAG ATAGTGATAG TATGTACTTT 241 ATAGGATTAT TGTGAAAAAT AAATGAAATA TCAGATTTAT TTAGGATAAC ACCTGGCATA 301 TGTTTGGTAT TCAGAATTAG TTGCTGCTGT TTTATTCTGC TCTCCCTTGC ATCCCACTTT 361 TCTAAGTTGT AAACTAAATA GTTGTACACA GATTGACAGA TTAAGAAAGG CTTGTGATTG 421 TGCTAGACCT ATGCCTATGC CTCTGTCTCA CCAGATTCCA GGTGTATATG TGGAGGTGGG 481 ATAGGGAGTG GAGTAAGTGG GTAAATATTA AATTGCCCAG TTGGGCACCA TCCTGAATAT 541 TATCTCTAAA GAAAGAAGCA AAACCAGGCA CAGCTGATGG GTTAACCAGA TATGATACAG 601 AAAACATTTC CTTCTGCTTT TTGGTTTTAA GCCTATATTT GAAGCCTTAG ATCTCTCCAG 661 CACAGTAAGC ACCAGGAGTC CATGAAGAAG ATG (2) INFORMATION FOR SEQ ID NO:2501: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 7621 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2501: 1 GATCTTCATG TGGAATGACT GGTTTCATTC AATAGACTTA ATTCAGCAGT CTGTGGGGAA 61 GAGCAAGGTA TGATAGAATG GTTCCTCAAG TGCTTCAGAT GTGAAGTGGG TTTAAATATA 121 CTGTCCCTGT CTTCTTCAGA GTTTTGGTAA AGATAAAATA GGACACTCAT TTAAAAGCAA 181 TCTTTGCAAA TGACAAGCCA CTATAGACAT TAATAGAGTT TTCATTTCCA GTATTATCAT 241 TAATATCAGA TCCTGGAAGA AGGTTGAGCC TTGACCTAGA GCAAAAAAAC AGAAGAATTA 301 GTAAAGGAAT CCTGGAGAAA GCCCCTGCTG TGTATTTAAA GGAGAAAGGG AGATCATGTT 361 GGGAAATTAT AATATTAAAA GTAAACAAAA GCTAGGAAGT AAAATAAAAT AAATTATATG 421 GCCTAGATCC CCATAAGTAA TGGTTTAACT TCTGCCTTCC TGTGTTCTGA GCCAGATTAG 481 GGCACAGTAG AGAAAGAGGA GTCTCTGAAA ATGTTTCCAA TTTCGCTGGT CAGACAGCGG 541 ATCATCAGTG AATCAGATGA AAATTTGTGG ATTTATGCAC TAACTGATCA GCAGGAAATT 601 AAACAAGAAA AGCGTTGGTA GCTCTGGTGA ATCCCAAAAG AATTTGGCAG TTGCTAGCCA 661 TGCTCCTGAA TATGTATAAA CAGTACATCA TATGACTAAG AGTTTGACTT AGGGGTTAGA 721 TTTTATGTGT TTGAACCCCA AATTAGTTAT TTAATAGTTG GCACCCCAAA ACAAGTTACT 781 TAACCTCACT AAGATTCAGT TTTCCTGTTT ATAAAATGTA GATAGTGATA GTATGTACTT 841 TATAGGATTA TTGTGAAAAA TAAATGAAAT ATCAGATTTA TTTAGGATAA CACCTGGCAT 901 ATGTTTGGTA TTCAGTAATT AGTTGCTGCT GTTTTATTCT GCTCTCCCTT GCATCCCACT 961 TTTCTAAGTT GTAAACTAAA TAGTTGTACA CAGATTGACA GATTAAGAAA GGCTTGTGAT 1021 TGTGCTAGAC CTATGCCTCT CTCTCACCAG ATTCCAGGTG TATATGTGGA GGTGGGATAG 1081 GGAGTGGAGT AAGTGGGTAA ATATTAAATT GCCCAGTTGG GCACCATCCT GAATATTATC 1141 TCTAAAGAAA GAAGCAAAAC CAGGCACAGC TGATGGGTTA ACCAGATATG ATACAGAAAA 1201 CATTTCCTTC TGCTTTTTGG TTTTAAGCCT ATATTTGAAG CCTTAGATCT CTCCAGCACA 1261 GTAAGCACCA GGAGTCCATG AAGAAGATGG CTCCTGCCAT GGAATCCCCT ACTCTACTGT 1321 GTGTAGCCTT ACTGTTCTTC GGTAAGTAGA GATTCAATTA CCCCTCCCAG GGAGGCCCAA 1381 ATGAATTTGG GGAGCAGCTG GGGTAGGAAC CTTTACTGTG GGTGGTGACT TTTTCTAGGA 1441 CATGTGCAAA CTATTGGGCA TTTCCCAGGG ACTCTGTAGT GGAGCCAAGC TAGAAAGCAG 1501 AGGCAAGTGG GCTGAGCAAC ACCTAAGGAG GAAGCCAGAC TGAAAGCTTG GTTCCTTGCA 1561 TTTGCTCTGG CATCTTCCAG AGTGCAAATT TCCTACCAAG GTAATGAGGG TAGAGGAGAG 1621 AAAGAAGCTC TTTCTTCCCC TGATTCTCAT TCCTGAAAAG ACGGTTGGTC CTTAAAATTC 1681 CATGGATGTA GATCTTATCC CCACACCCAG ATTCTAGTCC TCTGGAGATA AAGAAGACTG 1741 CTGGACACTA ATGTATCCTC TCTGGACTTT TGCAGCTCCA GATGGCGTGT TAGCAGGTGA 1801 GTCCTCTGTT CTTGTTCCCT TGGTGTATCA ACATGTCTGG GCATTGCTTT CCTCTCACTA 1861 TTTTCTTCGT CCCATCACTT CTGCTTTCTA ATGAGCATGA ATCTGTTCCT TGGCCAGACT 1921 ACTTTCCCTC TCCACCTTGC CTTGTCTTTC TTTTTTTCCC TGATTCATTG CATTCTCTCA 1981 AGTCATTCTC TCCTCTGTTT TAGTCAATAA CCATGTCTGT TGCACATATA CATGTCTCAT 2041 TCTCTCTCCT AGACACTTTG GCATGATCTC GCTCAATAAT TACATTATTA TTATTATTGC 2101 CATTTTATAA TTGAGGATGC TGAAACTCAG TGATTTTCTG GTGGTTACAT GGCTAAGGAA 2161 CTGGATTTCA ACGTAAGTTC CTTGGATCTA AGTCCAGTTC TCTTCTGACT ATATCACCCT 2221 TTTGTTATCA CCATGTATCT ACTTCTTTGG TCTCTGTTCA AATTTGCACT ACATCCCCTT 2281 GTTCCAGGAA GCCATTCAAG ACTGACTTTC TTAGTGCCTC TCACTACTTT CTGGAACTGA 2341 CATATGTTTT TCACTCTTA TATACTTACA ATTAAATAGT CATAAATATT CAGAGCTTGG 2401 AGAAACCTTA TATTTCATCC AGTCCAGTAA ATTTATCCAT CCATAATTCA CTCATTCATT 2461 CACATAATAA ATATTTAATG TAACAATGGT TGAACATGGC AGACAGTGTT TCTACCTCA 2521 AAGAGATTGC AGTCCTCATT TACAGATACT GAATTGAAAT TAACAGAAGT AGAGTGAGTC WO 00/09525 PCT/US99/17712 EPI-109 654 2581 AGCTCAAATC ACATAGTGAA TTCCTTTCTT TGTTTTTAAA TCTCCTGCAT ATGTGTCCTG 2641 TCTTTCTCCC TGTGTTGGGC GTTCCCTGGG GCACCAATAC TAATTTCTCC TTCCCCTAGA 2701 AATCAAAACA GGGTCTTATC ACCAACAGAA TAAGGACAGG TTGACCACTG ATTGTCAGAA 2761 TATTGCTTCG TTTGTACTTT TAAGCCTAGA CAGTTTTCAA TGACTTTTTT TCTCTCTACA 2821 TGTCTTTTCA TATTTTTATC TTCTTGAAGT CCCTCAGAAA CCTAAGGTCT CCTTGAACCC 2881 TCCATGGAAT AGAATATTTA AAGGAGAGAA TGTGACTCTT ACATGTAATG GGAACAATTT 2941 CTTTGAAGTC AGTTCCACCA AATGGTTCCA CAATGGCAGC CTTTCAGAAG AGACAAATTC 3001 AAGTTTGAAT ATTGTGAATG CCAAATTTGA AGACAGTGGA GAATACAAAT GTCAGCACCA 3061 ACAAGTTAAT GAGAGTGAAC CTGTCTACCT GGAAGTCTTC AGTCGTAAGT TCCAGGGATA 3121 TGGAAATACA GATCTCTCAT GTGAGGGATG GCTCATCTCA AGATGGGAAA AAACAGGTTA 3181 TTCCAAGGGT TAGGACACCA GAGTGGGATT CAAGGCCTCT CATTTTTAAG ACCCCTGCAT 3241 TGGCTGGGCA CAGTGGCTCA CGCCTGTAAT CCCAGCACTT TGGGAGGCTG AGGCAGGTGG 3301 ATCACGAGGT CAGGAGATCG AGACCATCCG GCTAACATGG TGAAACCCCA TCTCTGCTAA 3361 AAAATATATA TATATAAAAT TAGCCGGGCG TAGTGGTGGG CACCTGTAGT CCCAGGTACT 3421 CGGGAGGCTG AGGCAGGAGA ATGGTGTGAA CCCAGGAGGT GGAGGTTGCA GTGAGCTGAG 3481 ATCACGCCAC TGCCCTCCAG CCTGGGCTAC AGAGCAAGAC TCCGTCTCAA AAAATAAATA 3541 AATAAATAAA AAAGACCCCT GCATCTCTTT TCTTCTACCC CCTTCCCTTT TGATTACTTG 3601 TATGCCTTCT TTCAATATTC TAGTCATCTC TCAATATTAT TCCTCCACCC TATTTTCCTC 3661 TATCTTTTCT GCCTAGATTC AGGTATATAT TATGTGGTCA AACAGCATGA CATATATGTG 3721 AACATTTCAA AGAGCTGTGT ATCTGGAATA GGATCAAAAG GTTTGACTTA AAGTTTTGCT 3781 CTGCATAATC CATATGGCAG GACCTGAATA TTAGGTTGTA CTCTTCGTTA TGAAACATAT 3841 CTGGGTACAT TTCCTTATGT CCTCTGTTGT TACTTAAGAA CACATATTTC ATGCTTGTTT 3901 CATTTTTATC ACTCCTACTG CCAACAAATA GCATAGCATG CTTAGGCACA TGTGGCTTAA 3961 TTAGCAAATG TTGAATAAAC AAATTAATGA TTTTGAATAG TGACCAATAC GTCTCTTTTA 4021 TACTCTATAT TTTTCTCTTG AGTGAAAAAA AATGTTTCAA CCTCCATATG TAAATTCCAA 4081 ACACAAACTA AAGCAATGTA GAATAGCTTC TTTATTCCCT GGAGTAGGTT CTAGAGAAGT 4141 CCTAAAGGAT TGGTCCTAAA TTAATTATGC TTATTATGCT AGCGATATTT CCTTTCAAAA 4201 TTCTCCTTTA ATGAATGCTT TTTAATTTTT ACAAAAGCAT TAACCATAGA ATGTGATTCT 4261 TGTCTTTCAC TGACTCATTA GTGACAAATA TTTGTTGAGT ACCTACCAAC TCCTAAGTAT 4321 TGCTACCAAC TCCTAAATAC TGTGTTGGGC ATTCAGAATA GAATGTAGAA CTAGACAGGG 4381 TCCCTGACTT CTTGGAGCAC AGAGCAGTAT GGGAAGAGGA CATTAAATAA AGAATTACAT 4441 AAGTAATTAA TTTAAATTAT ACATGTTTTG AAGAAGTTTT TTTTTGACAA CTATAATTAA 4501 CACTAGAACT GGGAAGTTTC TATAAGGTAA GAGAGGACAA AATAGACACT CTCCTAAGCT 4561 AAAATTCCCA AGAAAGACTG TTTATTTTCC CCTAACTAAC TAGAACTAGC AACAGAAGAT 4621 CTGAAAGGAA TTCTGGCTTT CAAGTGTTCC ATGTATGGAC TCATCAGGGA GGTCCGAGAG 4681 GCTTTGTGGC CCCAGACTGA CTTTTCAGGA GGGGAAAGGA TTTATCAATA CACAAGACAG 4741 GCTCTAAGCA TTATTTTGTG CCCTTTAAAA ATCCACTTTA TGAGCCAAAA AGTGAGTTAA 4801 TGATAATTCA TAGTTTCTGA CACATGCTCT ATGCGTGGCT CTCTTTTCTC TATTCATTCT 4861 CTCTCTCTTC ATTTATTCTT AAATAAATAA TGTAATGAAT GTTCTTCAGA CTGGCTGCTC 4921 CTTCAGGCCT CTGCTGAGGT GGTGATGGAG GGCCAGCCCC TCTTCCTCAG GTGCCATGGT 4981 TGGAGGAACT GGGATGTGTA CAAGGTGATC TATTATAAGG ATGGTGAAGC TCTCAAGTAC 5041 TGGTATGAGA ACCACAACAT CTCCATTACA AATGCCACAG TTGAAGACAG TGGAACCTAC 5101 TACTGTACGG GCAAAGTGTG GCAGCTGGAC TATGAGTCTG AGCCCCTCAA CATTACTGTA 5161 ATAAAAGGTG AGTTGGTAAA GGAAAGGAAA AGCATCCATA GCAGGGGAAG GAAGAGAGAA 5221 CTTCTGAGCC TGAGCAGTTG CAGCTTGTAG AAGGGGGGCA CCTGTGATAC ACTGGAAAGC 5281 CTACCAGACT TGCAATGAGG AGACCTGGGT GATAGTATAT ATCTCAATCT CTGTTTCAAA 5341 GCCTTGACTT GTTAAATGGT GATAGTAATA CCTGCTTGCA CTATGAAATT TTTATGAAGA 5401 TTAATGTGGT AATATTTGTG AAATGACTTT GTAAACTGTT AAGCACTACC CAAGCATAAC 5461 AGATTGTGAT TACTATTTTG ATCTCAAAGT CATCTGTTGC TCCTGGGGGA ACACTTATAT 5521 TTATCAAATT GAAAAAAAGT TTCAAAGTTG AATGAAGAAA GGATATAAAG AGCTTGAGGA 5581 GCCCATTCCA GCTTAGGAGG GCTGGGAAAG GAAACCAGCA AGTCAGTAAG CTGTGTGCCT 5641 GTGTATTGAG GGAGGAGGGA ATGGACTTGA TATGGAGAGG GTAGGGAGGT GGACTGCCTC 5701 TATGGCCTGT AAGAAAAACT GCTCTCTCCA AACTCTTTAT AAGAGAGGGA GCCTGTGAAG 5761 TATTCACTTT TGAAGGAGAA AGTTAGACTT TTCCTTCACA CACTTTGTAC ATAATAATGT 5821 TTAAAAAAGC ATGAGGTCAA AATACATAAT TAAGTCCTAG CAGTTCTCTG TTAACTAATT 5881 TGAGACTGAA GTGCTATGTA CTTGTCTCTA GGCTTCCAGT ATCTTCATCT GTAAAACAGA 5941 ATATTTGGTC TAGATTCCAT TAGAATCATT TGATAACTTA AAAAATATAT TGATGCTCAT 6001 GTCTCATTTC TTGAGATTCT GATTTAATTG GTTTGGGGTG CAGCCTGGGT ATACGTATTT 6061 TTCATAGGTC TTTCACATAA TGGTAATGGG TAGCCAATAT TGAGAATCAC TTGTCTAGGT 6121 GATCTTTAAA TGATTTCTGG ATGTAATATT CTGAGGCTCT ATAATTTGAG ACTAATCACA 6181 AAAATCGGTA CAGTTTATAA ACAGACTAAC AGAACCACAA AATAATAGAA TTGGAAGGCA 6241 ATTTAACTAG TGCAATTTCT TCATTTTGCC TAACAGGCAT GTAAGAAATG ATGATTGATT 6301 GAGTAATAGG CATTGATGAC CCCTGTCCTC ACTTTGTCCC CTTTCCACCC CTTAATTATA 6361 TGTGAATTCT GGTCTTGTCA TTTCGAATAA GGGGTTTATC TTTCCTATTG TCTTCCCCTC 6421 TGGGCACGGC ACACTGGCTA CTGGAGTTAA GAGGAAATGC TTAGGACTCC CTGTGGCTCC 6481 AGGGAGCACC AACAGAGCAA CTCAACCTAG TGTTAATCTG AGTGTTTTCT CTGTGCTTCT 6541 GGATGCCACA TCACGCTAAA AATGAAGGAC AAAGCTTGGT CTTTCTCTTA GGGAGGATGA 6601 AACTCTGAAC CTCATTTTTC AGTTCCCAAG ATGAATTATG TTTCTCATTG CATCTGTGTT WO 00/09525 PCT/US99/17712 EPI-109 655 6661 CCACTACAGC TCCGCGTGAG AAGTACTGGC TACAATTTTT TATCCCATTG TTGGTGGTGA 6721 TTCTGTTTGC TGTGGACACA GGATTATTTA TCTCAACTCA GCAGCAGGTC ACATTTCTCT 6781 TGAAGATTAA GAGAACCAGG AAAGGCTTCA GACTTCTGAA CCCACATCCT AAGCCAAACC 6841 CCAAAAACAA CTGATATAAT TACTCAAGAA ATATTTGCAA CATTAGTTTT TTTCCAGCAT 6901 CAGCAATTGC TACTCAATTG TCAAACACAG CTTGCAATAT ACATAGAAAC GTCTGTGCTC 6961 AAGGATTTAT AGAAATGCTT CATTAAACTG AGTGAAACTG GTTAAGTGGC ATGTAATAGT 7021 AAGTGCTCAA TTAACATTGG TTGAATAAAT GAGAGAATGA ATAGATTCAT TTATTAGCAT 7081 TTGTAAAAGA GATGTTCAAT TTCAATAAAA TAAATATAAA ACCATGTAAC AGAATGCTTC 7141 TGAGTATTCA AGGCTTGCTA GTTTGTTTGT TTGTTTTCTA CTAAAGGCAA GGACCATGAA 7201 GTTCTAGATT GGAAATGTCC TCTCTTGACT ATTGCAAGTG CGATCTAGGA ATGAAAAGAC 7261 ATAGGAGGAT GCCAGTGAGG TGGATCATTT TTATGCTTCT TCTTCAGCTT ACTAAATATG 7321 AACTTTCAGT TCTTGGCAGA ATCAGGGACA GTCTCAAGAC ATAGGACTCT CAGGATGAAG 7381 TAGAGTCCAG GATTCCTCTG TGATTGTTTT GCCCCTCCCA AATTTATATC TTGAACTTAT 7441 GTCTTGTATC TTTATACAGC ACCTGAACCA AGCATTTTGG AGAAATTCCA GCTAATAATA 7501 ATAACCAAAA CCTTCGGCTC TGAAAACAGT CCAGGACTGA ATAAGATCTT GGGCAAAAGA 7561 ACTAGACAGT TTTGGTTTAT TTTCCCTTTC ATTTTATGTC TTCATCATAG TCATTGGAGG 7621 CTCATTCTTC TTGTCATGGA GTAAATGGGA TTAAAGTTC (2) INFORMATION FOR SEQ ID NO:2502: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1198 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2502: 1 TACTAAGAGT CTCCAGCATC CTCCACCTGT CTACCACCGA GCATGGGCCT ATATTTGAAG 61 CCTTAGATCT CTCCAGCACA GTAAGCACCA GGAGTCCATG AAGAAGATGG CTCCTGCCAT 121 GGAATCCCCT ACTCTACTGT GTGTAGCCTT ACTGTTCTTC GCTCCAGATG GCGTGTTAGC 181 AGTCCCTCAG AAACCTAAGG TCTCCTTGAA CCCTCCATGG AATAGAATAT TTAAAGGAGA 241 GAATGTGACT CTTACATGTA ATGGGAACAA TTTCTTTGAA GTCAGTTCCA CCAAATGGTT 301 CCACAATGGC AGCCTTTCAG AAGAGACAAA TTCAAGTTTG AATATTGTGA ATGCCAAATT 361 TGAAGACAGT GGAGAATACA AATGTCAGCA CCAACAAGTT AATGAGAGTG AACCTGTGTA 421 CCTGGAAGTC TTCAGTGACT GGCTGCTCCT TCAGGCCTCT GCTGAGGTGG TGATGGAGGG 481 CCAGCCCCTC TTCCTCAGGT GCCATGGTTG GAGGAACTGG GATGTGTACA AGGTGATCTA 541 TTATAAGGAT GGTGAAGCTC TCAAGTACTG GTATGAGAAC CACAACATCT CCATTACAAA 601 TGCCACAGTT GAAGACAGTG GAACCTACTA CTGTACGGGC AAAGTGTGGC AGCTGGACTA 661 TGAGTCTGAG CCCCTCAACA TTACTGTAAT AAAAGCTCCG CGTGAGAAGT ACTGGCTACA 721 ATTTTTTATC CCATTGTTGG TGGTGATTCT GTTTGCTGTG GACACAGGAT TATTTATCTC 781 AACTCAGCAG CAGGTCACAT TTCTCTTGAA GATTAAGAGA ACCAGGAAAG GCTTCAGACT 841 TCTGAACCCA CATCCTAAGC CAAACCCCAA AAACAACTGA TATAATTACT CAAGAAATAT 901 TTGCAACATT AGTTTTTTTC CAGCATCAGC AATTGCTACT CAATTGTCAA ACACAGCTTG 961 CAATATACAT AGAAACGTCT GTGCTCAAGG ATTTATAGAA ATGCTTCATT AAACTGAGTG 1021 AAACTGGTTA AGTGGCATGT AATAGTAAGT GCTCAATTAA CATTGGTTGA ATAAATGAGA 1081 GAATGAATAG ATTCATTTAT TAGCATTTGT AAAAGAGATG TTCAATTTCA ATAAAATAAA 1141 TATAAAACCA TGTAACAGAA TGCTTCTGAG TAAAAAAAAA AAAAAAAAAA AAAAAAAA (2) INFORMATION FOR SEQ ID NO:2503: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 894 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2503: 1 TCTCAATATA ATAATATTCT TTATTCCTGG ACAGCTCGGT TAATGAAAAA ATGGACACAG 61 AAAGTAATAG GAGAGCAAAT CTTGCTCTCC CACAGGAGCC TTCCAGTGTG CCTGCATTTG 121 AAGTCTTGGA AATATCTCCC CAGGAAGTAT CTTCAGGCAG ACTATTGAAG TCGGCCTCAT 181 CCCCACCACT GCATACATGG CTGACAGTTT TGAAAAAAGA GCAGGAGTTC CTGGGGGTAA. 241 CACAAATTCT GACTGCTATG ATATGCCTTT GTTTTGGAAC AGTTGTCTGC TCTGTACTTG 301 ATATTTCACA CATTGAGGGA GACATTTTTT CATCATTTAA AGCAGGTTAT CCATTCTGGG 361 GAGCCATATT TTTTTCTATT TCTGGAATGT TGTCAATTAT ATCTGAAAGG AGAAATGCAA 421ACATATCTGGT GAGAGGAAGC CTGGGAGCAA ACACTGCCAG CAGCATAGCT GGGGGAACGG 481 GAATTACCAT CCTGATCATC AACCTGAAGA AGAGCTTGGC CTATATCCAC ATCCACAGTT 541 GCCAGAAATT TTTTGAGACC AAGTGCTTTA TGGCTTCCTT TTCCACTGAA ATTGTAGTGA 601 TGATGCTGTT TCTCACCATT CTGGGACTTG GTAGTGCTGT GTCACTCACA ATCTGTGGAG 661 CTGGGGAAGA ACTCAAAGGA AACAAGGTTC CAGAGGATCG TGTTTATGAA GAATTAAACA 721 TATATTCAGC TACTTACAGT GAGTTGGAAG ACCCAGGGGA AATGTCTCCT CCCATTGATT 781 TATAAGAATC ACGTGTCCAG AACACTCTGA TTCACAGCCA AGGATCCAGA AGGCCAAGGT 841 CTTGTTAAGG GGCTACTGGA AAAATTTCTA TTCTCTCCAC AGCCTGCTGG TTTT WO 00/09525 PCT/US99/17712 EPI-109 656 (2) INFORMATION FOR SEQ ID NO:2504: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 11298 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2504: 1 AAGCTTTTCA AAGGTGCAAT TGGATAACTT CTGCCATGAG AAATGGCTGA ATTGGGACAC 61 AAGTGGGGAC AATTCCAGAA GAAGGGCACA TCTCTTTCTT TTCTGCAGTT CTTTCTCACC 121 TTCTCAACTC CTACTAAAAT GTCTCATTTT CAGGTTCTGT AAATCCTGCT AGTCTCAGGC 181 AAAATTATGC TCCAGGAGTC TCAAATTTTC TTATTTCATA TTAGTCTTTA TTTAGTAGAC 241 TTCTCAATTT TTCTATTCAT CACAAGTAAA AGCCTGTTGA TCTTAATCAG CCAAGAAACT 301 TATCTGTCTG GCAAATGACT TATGTATAAA GAGAATCATC AATGTCATGA GGTAACCCAT 361 TTCAACTGCC TATTCAGAGC ATGCAGTAAG AGGAAATCCA CCAAGTCTCA ATATAATAAT 421 ATTCTTTATT CCTGGACAGC TCGGTTAATG AAAAAATGGA CACAGAAAGT AATAGGAGAG 481 CAAATCTTGC TCTCCCACAG GAGCCTTCCA GGTAGGTACA AGGTATTATT TTTTTCTACC 541 CTCAGTCACT TGTGGCAGGG GAAGTCATAG TCACGGTGCT TAGGAGATGA AACTTTATTG 601 ATTTAGGCAT GGATCCATCT AGTTTAATTA ATATATTGGG TATGAGGAAG CTACTTGCTG 661 TACTTTCCAT GTGGTTCTCT CTCCCTGGAG AGGAACATTT TTACTCAGCT TGCAAACTGG 721 AAATAGATTT TCTCACATTA GAAGCTCATT TTCTGGGTAT GAGACAGGAG AGTTCATACT 781 GTGTATGTAG ATCTCTGGCT TCTGGGTCTG ACATGTGCTG AGGGACACAT ATCCTTCACA 841 CATGCTTTTA TAAATACTTG ATAAAGTAAC CTGCTTCTTG ATTGGTCTTT ATAATCCATA 901 AGCTGTGGGA TGCTTCTCTG AAGATGAAAA TAGTAATAGA GTCCCATCTA GCTATTCAAA 961 GCCATTCCTT CATTGTATTC TGTGCACATG AAGTTGGGGT TTGTTACTGA CAAAATATAT 1021 TCAGATACAT TTCTATGTTA AAAGGATTGT GAGATGCATA GGTAAATGTG TTTATTTTCA 1081 GTTTTACTTG TCAACATAGA TGAATGAGAA AGAACTTGAA AGTAACACTG GATTAAGAAT 1141 AGGAAAATTT GGCATGGATT TTGCTCCATT TTGTCCCATC TAATCACTTG GATAGTGTTC 1201 AGGTGTTCTT GGTCAGTTAC TTGGATGCTC TGAGCTTTAG TTTCTTGGTG ATTACAATGA 1261 AGATTTGAAT TACAGGATGG CTTTGAAAAA ATAAACAAAA CTCCCCTTTC TGTCTGTCGA 1321 GAATGTTGCA CAGGGAGTTA CAGAATGTTC TCATGACTGA ATTGCTTTTA AATTTCACAG 1381 TGTGCCTGCA TTTGAAGTCT TGGAAATATC TCCCCAGGAA GTATCTTCAG GCAGACTATT 1441 GAAGTCGGCC TCATCCCCAC CACTGCATAC ATGGCTGACA GTTTTGAAAA AAGAGCAGGA 1501 GTTCCTGGGG GTGAGTGAGC CTCCTCCAAC TTTGACTAGA GTAAGGGTTG GGTCTAGAAA 1561 AGAATATTGA GTTGCATCAA CTGTTTTCCC ACTTGGATTC ATGAGAGGTG TTAGGTCCTT 1621 TAAAAAACAT GGTAGATAAA GAGTTGACAC TAACTGGGTC CTTTTGGGAA GAGCCAGAAG 1681 CATTTCCTCA TAAAGACTTT AAATTGCTAG GACGAGAATG GCCAACAGGA GTGAAGGATT 1741 CATAACTTTA TCTTTACTTA GATGTAAAGA ACAATTACTG ATGTTCAACA TGACTACATA 1801 CATAAAGGCG CATGGAGAAA AGTATTGGCC TTCCATGCAT TAGGTAGTGC TTGTATCAAT 1861 TCTTATAGTG GCTAGGGTAT CCTGGAAAAT CTTACGTGTG GATCATTTCT CAGGACAGTC 1921 TAGGACACTA ACGCAGTTTC TCATGTTTGG CTTCTATTAT TAAAAAATGA TACAATCTCG 1981 GGAAAATTTT TTTGATTTTC ATGAAATTCA TGTGTTTTTC TATAGGTAAC ACAAATTCTG 2041 ACTGCTATGA TATGCCTTTG TTTTGGAACA GTTGTCTGCT CTGTACTTGA TATTTCACAC 2101 ATTGAGGGAG ACATTTTTTC ATCATTTAAA GCAGGTTATC CATTCTGGGG AGCCATATTT 2161 GTGAGTATAT ATCTATAATT GTTTCTGAAA TAACACTGAA CATAGGTTTT TCTCTTTCTC 2221 AGATCTAACC AGTTGTTTAT TCCCAGTATT AAGATGATAT TTATAATTCT TAATTATAAA 2281 TATATGTGAG CATATATAAC ATAGATATGC TCATTAACAA CAACAAAAGA TTCTTTTTAC 2341 AATTAACGGT GGGTTAAACA TTTAGCCCAC AGTTTTATCC CATGAGAAAC CTGAATCTAA 2401 TACAAGTTAA ATGACTTGCC TAAGGGCCAC TTGACTAATA GTAATTGAAC CTAAACTTTC 2461 AGAATCCAAC TCCAGGAACA TACTTCTAGC ACTATTCATC AATAAAGTTA TATGATAAAT 2521 ACATACAACT TTATCTGTCA ACTAAAAATA ACAACAGAGG CTGGGCATGG TGGCTCACAC 2581 CCGTAATCCC AGCACTTTGG GAGGCTGAGG CAGGTGGATC ACCTGAGGTC AGGAGTTTGA 2641 GACCAGCCTG ACCAACATGG TGAAACCTCA TCTCTACTAA ATATAAAAAA TTAGCTGAGT 2701 GTGATAGTGC ATACCTGTAA TCCAGCTACT TAAGAGGCTG AGGCAGGAGG CTTGTTTGAA 2761 CCTGGAAGGC AGAGGTTGCA GTGAGCTGAG ATTGTGCCAT TGCACTCCAG CCTGGGCAAT 2821 AAGTGCGAAC TCTGTCTCAA AATAATAATA ATAATAATAG AAAATAAAGT TGTCTTCATG 2881 AAAAATGAGG AAAGAGATTG CTGGGGTGAG AAACATTAAG ATCAATGGGC ATATGGTGAC 2941 CTTCTATGCC CTAGAAACTC TTTTANGGTA TTTTCTCCTG GTATCTCTTT TACNCATCGT 3001 TCTATCTGGA AAAATAGGTG GATGAGTGAG ATAATAACGG TATATACTTT TTAAAGGTCT 3061 AATTGACATA TATAAATTGC AAGTATTTCA GATGTCAATT TGCTAACCTT GACACACATA 3121 GACACACATG AAAACATCAC CACATTAATA CAATGTATGT ATCCATCATT CCAAAAGCTT 3181 CCCTGTGTAT CTTTGTAACT CTTTCTTCCT CCCTCCACTC CTTGTCCTCT CGTTCCCAAG 3241 AAAACATTGA TCTGCTTCCT GTGAATATAA ATTAACTTAC ATTTTTTAGA GCTTTATATA 3301 AGTATGTTCT CTTTACTGTT TGTCTTCCTT CGCTGCACAG TTATTTTGAG ATTCTTCAAG 3361 TTTTTTCTTT ATATCGATAC TTCATTCACA AGAATATATT TTAATTCTAG ACTATGTCAC 3421 ATTGACTTTG TCGTCTGCTA AATCCTTAGT GCTCAGATGA CTTGTTCAGG ACTCTCCTTG 3481 AACCTGTACC TCTGTTANAT TGAAACTTGT CTCTACTGTC TTTTTATTTC AAACACAGCT 3541 TATTAGGTGT CTCTCAACCC ATCAAACNCA CAATCTGAGT CTTTAGGAGA TTGCTTTGAA 3601 TTTGTGCTAT TGACTTATAT NTATATNAAA TNTGTAAATG TTTGGTAAAA ATATCATCAT 3661 GTACNTTTTC ATAATTACGC TATNTNCACA TGATATATGT CAGACTCTGG AAATATGCAT WO 00/09525 PCT/US99/17712 EPI-109 657 3721 GCCACAGACA CGTGTT:CTT CCTAaAGGG GCTGATGCAA GACNCACATA CNAATAGACG 3781 ATTGCAGTAG AATGAGAG:C GTGGTCTAAN CaCTACATGT CCTGATGTTG CTCGGACAGT 3841 TACTACNCCA AGAGTACCCC CTGCaTTGTC AGGGTTAGCA TCTCCTGGAA GCCTCATGTA 3901 AATGAAGAAT TTCATGCTCC ATCCAGGACC TAATGAATAA GAATCTGCAT TTTAGCAAGA 3961 CCCTCATATG ATTCATATAC ACTTTTTTTT TTTTTTTTTA CATGGAGTCT CACTCTTGTC 4021 GCCCAGGCTG GAGTGCAATG CCATGaTCTT GGCTCACTGC AACCTCTGCC TCCCGGGTTC 4081 AAGTGATTCT CCTGTCTCAG CCTCCCTAGT AGCTGGGACT ACAGGTGCAT GCCACAGTGG 4141 CTGGCTAATT TTTGTATTTT TACTAGAGAC AGGGTTTCAC CATTTTGGTC AGGCTGGTCT 4201 TGAACTCATG ACCTCCGGTG ATTCCCCCGC CTCGGCTTCC CAAAGTGCTG GGATTACAGA 4261 CATGAGCCAC CACACCCGCC TTATTCGTAT ACNCATTTAA TTCTGAGAAG CACTCTATAG 4321 AAAATAAGAA TAAGAAAATA TTGGGCTCAC AGGTGACATT AATAAGTAAC TTTATCGAGT 4381 ACCCCAAATT TTACCTATGT TTGGAAGATG GGGTTAAAAG GACACATTGA AAACAAGAAC 4441 TCATTGTGGC TTTTTTTTCC TCCTTTTTGA ACAGTTTTCT ATTTCTGGAA TGTTGTCAAT 4501 TATATCTGAA AGGAGAAATG CAACATATCT GGTGAGTTGC CCGTTTCTGT CTTTGTCCAT 4561 CCTTGAAAAG ATAAGAAGAA CAGAGTTTTA AGAGTCTTAA GGGAAACACA TCTTTGTCTC 4621 CTATATTACT TGTGAATGTG GATATATGAT TTTGTTTCAA TCTATTTTGT GTCCTAAGGC 4681 TTTTTGCAAC AGAAGTTGGA TATATCATTA GAAACATAAA TTGTACCATT TAACATACAT 4741 GAAGTTTATG T.TTACCTTGA CGTTCTTCTA AAAAGTGTCC TACACCGGCA TTGTCCTTGT 4801 AGGCATATTC ACATGATCAA ATAAAATAAT TAGTTTTCAA TTAAGGAGAA TATTTGAGGA 4861 AAGACCGTAC GTGTTCATGT GGTTCCTGAA GGCAGTCCAG TGAGAAAGTA ATATATGCTT 4921 CATTAAACAA TGCGGACATT TTCAGGGTTT CCCTTTTTAA CCAAAATTTG GAAGCAATGT 4981 GGAATTTACT GGATGCATCC AGCCCTGAAA TGAAGATAGG TTTATTGAAT GTGCCAGCAA 5041 GTGCAGGCCC AGGTCTGAGT GTTCTTCATT ATTATCAGGT GAGAGGAAGC CTGGGAGCAA 5101 ACACTGCCAG CAGCATAGCT GGGGGAACGG GAATTACCAT CCTGATCATC AACCTGAAGA 5161 AGAGCTTGGC CTATATCCAC ATCCACAGTT GCCAGAAATT TTTTGAGACC AAGTGCTTTA 5221 TGGCTTCCTT TTCCACTGTA TGTATTTTTT TTTGTGTGGG AAGACTAAGA TTCTGGGTCC 5281 TAATGTAAGT AAGAAGCCCT CTTCTCCTGT TCCATGAACA CCATCCTTTT CTGTAACTTC 5341 TATTACACAG TATAGTGGTT CTGTAAGTTC ACACAGCCCA GGGAGATGCT GGCTGCCCAC 5401 TCCCCTCAAC CCAGGCAAAT TCCTCGGGGT TAAAGTTATC TACTGCAAGT GACGATCTCT 5461 GGGTTTTTCT GTGCCTGTGT TTGTGTGTGT GTGTGTGTGT GTGTGTGTGT GTATGTGTCA 5521 CTTTAAAAGG ACTGGTCAGA TGGTAGGGAG ATGAAAACAG GAGATGCTAT AAGAAAATAA 5581 ACTTTTGGGG CGAATACCAA TGTGACTCTT TTTGTTTGTC ATTTGTTGCT GTTCAATAGG 5641 AAATTGTAGT GATGATGCTG TTTCTCACCA TTCTGGGACT TGGTAGTGCT GTGTCACTCA 5701 CAATCTGTGG AGCTGGGGAA GAACTCAAAG GAAACAAGGT AGATAGAAGC CCGATATAAA 5761 ATCTTGAATG ACAGGTTAAC GAATTGGAGC TTTATTCCTT AAAATATGGC CTGGGTTTTC 5821 TGAAACATTT CTTCCAGAAA ATAGTTTCTC CAAGTTTTAT TACTTTGGTT TACAAATCTC 5881 ACATTTAAAT CACATTTTAT ACCATAACTA GCACACATTT CATAATATTC CTCTGAATGA 5941 GGGTTGGGAT AATAGGACTG ATATGTTAGA AATGCCTTAA AGTGTGTGGA GCATGAGAGA 6001 TGGATGTACA GAAGGCTTGT GAGGAAACCA CCCAGGTATC TGGCCTTGTT TTCTGCCCCA 6061 GAACTAGCCC CCTATTCCTG TTTCTGTTTT ATTCCTTTGT TTCTTGACTT TTCCTTTCCA 6121 ACTTGCTCTA AAACCTCAGT TTTCTTTCCT TTCTGATTCA TGACTACCAA ATGTTTTCAC 6181 TTGCCTCACC CGTCCATTAC ACCTTTGATA AGAACCACCA GACCTTGTGC TCATGTACTT 6241 GCCCATGTCT GATGGAAGAA ACATACTCTC TCCATCTGTC CACTTTCCTG AGGCATTCAA 6301 GTCTAGCCAC CTTTTAAAAT CACTCTCCTC CAGGCTGGGC ACGGTGTCAC GCCTGTAATC 6361 TCAGCACTTT GTGAGGCTGA GGAGGGCGGA TCACTTGAAG TCAGGAGTTC AAAACCAGCC 6421 TGGCCAAATG GCAAAACCAA ATCTTCTTCA ATTATAACCA AATCTTAAAC CAAATCTCTA 6481 CTAAAAAATA CAACAAAACA AAACAACAAC AACAAAAACA GAAAAGGAAA CATTAGCCCA 6541 GCGTGGTGGC AGGTACCTGA GGTTCCAGAT ACTTGGGAGG CTGAAGCAGG AGAATCGCTT 6601 GAGCCCAAGA GATGGAGGTT GCAGTGAGCC GAGATCATGC CACTGCACCA CAGCCAGGGT 6661 GACAGAGCCA TACTTCCCAG CACATTGGA GGCCAAAGCT GAAGAATAAT TTGAGGTGAG 6721 GATTTGGAGA CCAGCCTGGC CAACATGGTG AAACTCCGTC TGTACTAAAA ATATAAAACT 6781 TAGTGGGGCA TGGGGGCACA CACCTGTAAT TTCAGCTACT TAGGAGGCTG AGGCAGGAGA 6841 ATTGCTTGAA CCCGGGAGGC GGAAGTGCA GTGAGCCAAG ATCGTGGCCA CTGCACTCCA 6901 GCCTGGGTGA CATAGTGAGA TTCTGTCTCA AAAAAAATAA AAGAAATTTA AAAAATCACT 6961 CTCTTCCAAA GATAGATAAA TAAGACAGCA GATATACTAA GGAATAACCT CACCAACTTG 7021 TCATTGACTG ACATGATTTC TTTTGGCCCA CTTGGCCAGC TAGTCTGGTT TGGTTTTCTG 7081 GAAATGAAAG AAATAATCAG AGTTTAATGA CAGAGAGCGT GAGACCCAGA AAGACAAAAG 7141 TAGATGAGGT AAGTCTCTTG AGCGAGACTT CTAGGGATGG GAAATTTGTG GTGATTGATA 7201 TGAAATGATT TTTCCCTTAT CAGGTTCCAG AGGATCGTGT TTATGAAGAA TTAAACATAT 7261 ATTCAGCTAC TTACAGTGAG TTGGAAGACC CAGGGGAAAT GTCTCCTCCC ATTGATTTAT 7321 1AGAATCACG TGTCCAGAAC ACTCTCATTC ACAGCCAAGG ATCCAGAAGG CCAAGGTTTT 7381 GTTAAGGGGC TACTGGAAAA ATTTCTATTC TCTCCACAGC CTGCTGGTTT TACATTAGAT 7441 TTATTCGCCT GATAAGAATA TTTTGTTTCT GCTGCTTCTG TCCACCTTAA TATGCTCCTT 7501 CTATTTGTAG ATATGATAGA CTCCTATTTT TCTTGTTTTA TATTATGACC ACACACATCT 7561 CTGCTGGAAA GTCAACATGT AGTAAGCAAG ATTTAACTGT TTGATTATAA CTGTGCAAAT 7621 ACAGAAAAAA AGAAGGCTG CTGAAAGTTG AGTTAAACTT TGACAGTTTG ATAATATTTG 7681 GTTCTTAGGG TTTTTTTTTT TTTTAGCATT CTTAATAGTT ACAGTTGGGC ATGATTTGTA 7741 CCATCCACCC ATACCCACAC AGTCACAGTC ACACACACAT ATGTATTACT TACACTATAT WO 00/09525 PCT/US99/17712 EPI-109 658 7801 ATAACTTCCT ATGCAAATAT TTTACCACCA GTCAATAATA CATTTTTGCC AAGACATGAA 7861 GTTTTATAAA GATCTGTATA ATTGCCTGAA TCACCAGCAC ATTCACTGAC ATGATATTAT 7921 TTGCAGATTG ACAAGTAGGA AGTGGGGAAC TTTTATTAAG TTACTCGTTG TCTGGGGAGG 7981 TAAATAGGTT AAAAACAGGG AAATTATAAG TGCAGAGATT AACATTTCAC AAATGTTTAG 8041 TGAAACATTT GTGAAAAAAG AAGACTAAAT TAAGACCTGA GCTGAAATAA AGTGACGTGG 8101 AAATGGAAAT AATGGTTATA TCTAAAACAT GTAGAAAAAG AGTAACTGGT AGATTTTGTT 8161 AACAAATTAA AGAATAAAGT TAGACAAGCA ACTGGTTGAC TAATACATTA AGCGTTTGAG 8221 TCTAAGATGA AAGGAGAACA CTGGTTATGT TGATAGAATG ATAAAAAGGG TCGGGCGCGG 8281 AGGCTCACGC CTGTAATCCC AGCCCTTTGG GAGGCCGAGG TGGGCAGATC ACGAAGTCAG 8341 TAGTTTGAGA CCAGCCTGGC CAACATAGTG AAACCCCGTC TCTACTAAAA ATACAAAAAA 8401 AAAATTAGCT GGGTGTGGTG GCAGTCACCT GTAGTCCCAG CTACTTGGGA GGATGAGGCA 8461 GGAGAATCGC TTGAACCTGG GAGGCGGAGG TTGCAGTGAG CCGAGATCGC ACCAGTGCAC 8521 TCCAGCCTTG GTGACAATGG GAGACTCCAT CTCAAAAAAA AAAAAAAAAA AAAAAAGATA 8581 AAAAGTCAGA AATCTGAAAA GTGGAGGAAG AGTACAAATA GACCTAAATT AAGTCTCATT 8641 TTTTGGCTTT GATTTTGGGG AGACAAAGGG AAATGCAGCC ATAGAGGGCC TGATGACATC 8701 CAATACATGA GTTCTGGTAA AGATAAAATT TGATACACGG TTTGGTGTCA TTATAAGAGA 8761 AATCATTATT AAATGAAGCA AGTTAACACT CTAAGAGAAT TATTTTGAGA TAGAAGTGAA 8821 GCTAAGCTAA ACTTCACATG CCTATAATTG GAGGGAAAAA CTAAGGATAA AATCTAGCCT 8881 AGAAGATACA ATAATTAGTC ATAAACATGC ATTGTGAAAC TGTAGAGAGC AGGTAGCCCA 8941 AAATAGAGAA AGATTAGATA AAGAGAAAAT AAGTATCCAT CAGAGACAGT ATCTCTAGGC 9001 TTGGGCAAGA GAAAAGTCCA CAGTGATAAG CAACTCCACC TAAGGCATGA ATATGCGGCA 9061 GAGAAAACAG CAATAGTGAA TGAATGCAAA AGGTGCTGAG CAAATTCCAC ACATGAGTAT 9121 TGTGCATGAG TAAATGAATA AAACATTTGC AAAGACCTTT AGAGAAAGAG AATGGGAGCA 9181 TATGTGCGAA ATAAGATAGT TGATTATGAA TAGAAGGTAG TGAAGAAAAG CAAGCTAAGA 9241 AAAAATTCTG TTTATAAAAG AAGGAAAAGA TAGTTTATGT TTTTAGCCTA AGTATAAGAG 9301 TCCTACAGAT GGACTGAAAA AAATCAGTCT GAGAGTATTA GTCACAATTA ATGAAATAAT 9361 TACATTTTAT GTATTGAGGA TGCCAAGATT AAAAGGTGAC AGGTAGATGT TAATTTCCCT 9421 AGATTGTGAA AGTGATCACG ACAATCACAC AACAAATAAT TAAGTGACTT GGTATGCTTT 9481 ATTTAATTGT AGGGCCTGAG GTTTTCCATT CTCATTTTTC TAAAATACAA TTTTGTTTCT 9541 CCAAATTTGA CAGCAGAATA AAAACCCTAC CCTTTCACTG TGTATCATGC TAAGCTGCAT 9601 CTCTACTCTT GATCATCTGT AGGTATTAAT CACATCACTT CCATGGCATG GATGTTCACA 9661 TACAGACTCT TAACCCTGGT TTACCAGGAC CTCTAGGAGT GGATCCAATC TATATCTTTA 9721 CAGTTGTATA GTATATGATA TCTCTTTTAT TTCACTCAAT TTATATTTTC ATCATTGACT 9781 ACATATTTCT TATACACAAC ACACAATTTA TGAATTTTTT CTCAAGATCA TTCTGAGAGT 9841 TGCCCCACCC TACCTGCCTT TTATAGTACG CCCACCTCAG GCAGACACAG AGCACAATGC 9901 TGGGGTTCTC TTCACACTAT CACTGCCCCA AATTGTCTTT CTAAATTTCA ACTTCAATGT 9961 CATCTTCTCC ATGAAGACCA CTGAATGAAC ACCTTTTCAT CCAGCCTTAA TTTCTTGCTC 10021 CATAACTACT CTATCCCACG ATGCAGTATT GTATCATTAA TTATTAGTGT GCTTGTGACC 10081 TCCTTATGTA TTCTCAATTA CCTGTATTTG TGCAATAAAT TGGAATAATG TAACTTGATT 10141 TCTTATCTGT GTTTGTGTTG GCATGCAAGA TTTAGGTACT TATCAAGATA ATGGGGAATT 10201 AAGGCATCAA TAAAATGATG CCAAAGACCA AGAGCAGTTT CTGAAGTCCT CCTTTTCATC 10261 AGCTCTTTAT CAAACAGAAC ACTCTATAAA CAACCCATAG CCAGAAAACA GGATGTAGGA 10321 ACAATCACCA GCACACTCTA TAAACAACCC ATAGCCAGAA AACAGAATGT AAGGACAATC 10381 ACCAGCCATC TTTTGTCAAT AATTGATGGA ATAGAGTTGA AAGGAACTGG AGCATGAGTC 10441 ATATTTGACC AGTCAGTCCT CACTCTTATT TACTTGCTAT GTAAACTTGA GAAAGCTTTT 10501 TTCTCTTTGT GAACCTCAGG TTTTACATCT GAAAATGAGA AATTTGGAAC AAAAGATTCC 10561 TAACTGGTCT TTCTGTTCCC ATATTCTGTG ATTTTTCAAT ATTTAGGATT TTTGGTAATC 10621 ACAATTACTT AGTTTGTGGT TGAGATAGCA ACACGAATCA GAACTATTTG GTGGACATAT 10681 TTTCAAAGGA GTAGCTCTCC ACTTTGGGTA AAGAAGTGAT GCNGGTCGTG GTGGCTCACG 10741 CCTGTAATCC CAGCACTTTA GGGAGGCCAA GGCGGGTGGA TCACGAGGTC AGGAGATCGA 10801 GACCATCCTG GCTAACACGG TGAAACCCCG TCTCTACTAA AAAATACAAA AAATTAGCCA 10861 GGCGTGGTGG CGGGCGCCTG TAGTCCCACG TACTCGGGAG GCTGAGGCAG GAGAATGGCA 10921 TGAACCAGGG AGGCGGAGCT TGCCGTGAGC CGAGATAGCG CCACTGCAGT CCCTCCTGGG 10981 CAAAAGAGCA AGACTGCGTC TCAAAAAAAA AAAAAAAAAA AAAAAAAGAA GTGTGTGGAG 11041 TAGCAGGACA CCTGCAACAA TAATATTTTT CTAAATCCCT CTGAAAAATG CTAATCAAAG 11101 GGTTTTTTTC CTAAAAATTG TCTTAGAAAT AAAATTTCCC CTTTGGGAGA CCGAGGCTGG 11161 CAGATCACGA GGTCAGGAGA TAGAGACCAC GGTGAAACCC CGTCTCTACT AAAAATACTA 11221 AAAATTAGCC GGGGNGTGGT GGTGGGTACA CCTGTAGTCC CAGCTACTTG GAGGCTGAGG 11281 CTGGAGAATC ACGTGAAC (2) INFORMATION FOR SEQ ID NO:2505: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: - base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2505: 1 AACAAGAAAA GCGTTGGTAG CTCTGGTGAA TCCCAAAAGA ATGTGGCAGT TGCTAGCCAT 61 GCTCCTGAAT ATGTATAAAC AGTACATCAT ATGACTAAGA GTTTGACTTA GGGGTTAGAT WO 00/09525 PCT/US99/17712 EPI-109 659 121 TTTATGTGTT TGAACCCCAA ATTAGTTATT TAATAGTTGG CACCCCAAAA CAAGTTACTT 181 AACCTCACTA AGGTTCAGTT TTCCTGTTTA TAAAATGTAG ATAGTGATAG TATGTACTTT 241 ATAGGATTAT TGTGAAAAAT AAATGAAATA TCAGATTTAT TTAGGATAAC ACCTGGCATA 301 TGTTTGGTAT TCAGAATTAG TTGCTGCTGT TTTATTCTGC TCTCCCTTGC ATCCCACTTT 361 TCTAAGTTGT AAACTAAATA% GTTGTACACA GATTGACAGA TTAAGAAAGG CTTGTGATTG 421 TGCTAGACCT ATGCCTATGC CTCTGTCTCA CCAGATTCCA GGTGTATATG TGGAGGTGGG 481 ATAGGGAGTG GAGTAAGTGG GTAAATATTA AATTGCCCAG TTGGGCACCA TCCTGAATAT 541 TATCTCTAAA GAAAGAAGCA AAACCAGGCA CAGCTGATGG GTTAACCAGA TATGATACAG 601 AAAACATTTC CTTCTGCTTT TTGGTTTTAA GCCTATATTT GAAGCCTTAG ATCTCTCCAG 661 CACAGTAAGC ACCAGGAGTC CATGAAGAAG ATG 694 GATCTTCATG TGGAATGACT GGTTTCATTC AATAGACTTA ATTCAGCAGT CTGTGGGGAA 754 GAGCAAGGTA TGATAGAATG GTTCCTCAAG TGCTTCAGAT GTGAAGTGGG TTTAAATATA 814 CTGTCCCTGT CTTCTTCAGA GTTTTGGTAA AGATAAAATA GGACACTCAT TTAAAAGCAA 874 TCTTTGCAAA TGACAAGCCA CTATAGACAT TAATAGAGTT TTCATTTCCA GTATTATCAT 934 TAATATCAGA TCCTGGAAGA AGGTTGAGCC TTGACCTAGA GCAAAAAAAC AGAAGAATTA 994 GTAAAGGAAT CCTGGAGAAA GCCCCTGCTG TGTATTTAAA GGAGAAAGGG AGATCATGTT 1054 GGGAAATTAT AATATTAAAA GTAAACAAAA GCTAGGAAGT AAAATAAAAT AAATTATATG 1114 GCCTAGATCC CCATAAGTAA TGGTTTAACT TCTGCCTTCC TGTGTTCTGA GCCAGATTAG 1174 GGCACAGTAG AGAAAGAGGA GTCTCTGAAA ATGTTTCCAA TTTCGCTGGT CAGACAGCGG 1234 ATCATCAGTG AATCAGATGA AAATTTGTGG ATTTATGCAC TAACTGATCA GCAGGAAATT 1294 AAACAAGAAA AGCGTTGGTA GCTCTGGTGA ATCCCAAAAG AATTTGGCAG TTGCTAGCCA 1354 TGCTCCTGAA TATGTATAAA CAGTACATCA TATGACTAAG AGTTTGACTT AGGGGTTAGA 1414 TTTTATGTGT TTGAACCCCA AATTAGTTAT TTAATAGTTG GCACCCCAAA ACAAGTTACT 1474 TAACCTCACT AAGATTCAGT TTTCCTGTTT ATAAAATGTA GATAGTGATA GTATGTACTT 1534 TATAGGATTA TTGTGAAAAA TAAATGAAAT ATCAGATTTA TTTAGGATAA CACCTGGCAT 1594 ATGTTTGGTA TTCAGTAATT AGTTGCTGCT GTTTTATTCT GCTCTCCCTT GCATCCCACT 1654 TTTCTAAGTT GTAAACTAAA TAGTTGTACA CAGATTGACA GATTAAGAAA GGCTTGTGAT 1714 TGTGCTAGAC CTATGCCTCT CTCTCACCAG ATTCCAGGTG TATATGTGGA GGTGGGATAG 1774 GGAGTGGAGT AAGTGGGTAA ATATTAAATT GCCCAGTTGG GCACCATCCT GAATATTATC 1834 TCTAAAGAAA GAAGCAAAAC CAGGCACAGC TGATGGGTTA ACCAGATATG ATACAGAAAA 1894 CATTTCCTTC TGCTTTTTG.G TTTTAAGCCT ATATTTGAAG CCTTAGATCT CTCCAGCACA 1954 GTAAGCACCA GGAGTCCATG AAGAAGATGG CTCCTGCCAT GGAATCCCCT ACTCTACTGT 2014 GTGTAGCCTT ACTGTTCTTC GGTAAGTAGA GATTCAATTA CCCCTCCCAG GGAGGCCCAA 2074 ATGAATTTGG GGAGCAGCTG GGGTAGGAAC CTTTACTGTG GGTGGTGACT TTTTCTAGGA 2134 CATGTGCAAA CTATTGGGCA TTTCCCAGGG ACTCTGTAGT GGAGCCAAGC TAGAAAGCAG 2194 AGGCAAGTGG GCTGAGCAAC ACCTAAGGAG GAAGCCAGAC TGAAAGCTTG GTTCCTTGCA 2254 TTTGCTCTGG CATCTTCCAG AGTGCAAATT TCCTACCAAG GTAATGAGGG TAGAGGAGAG 2314 AAAGAAGCTC TTTCTTCCCC TGATTCTCAT TCCTGAAAAG ACGGTTGGTC CTTAAAATTC 2374 CATGGATGTA GATCTTATCC CCACACCCAG ATTCTAGTCC TCTGGAGATA AAGAAGACTG 2434 CTGGACACTA ATGTATCCTC TCTGGACTTT TGCAGCTCCA GATGGCGTGT TAGCAGGTGA 2494 GTCCTCTGTT CTTGTTCCCT TGGTGTATCA ACATGTCTGG GCATTGCTTT CCTCTCACTA 2554 TTTTCTTCGT CCCATCACTT CTGCTTTCTA ATGAGCATGA ATCTGTTCCT TGGCCAGACT 2634 ACTTTCCCTC TCCACCTTGC CTTGTCTTTC TTTTTTTCCC TGATTCATTG CATTCTCTCA 2694 AGTCATTCTC TCCTCTGTTT TAGTCAATAA CCATGTCTGT TGCACATATA CATGTCTCAT 2754 TCTCTCTCCT AGACACTTTG GCATGATCTC GCTCAATAAT TACATTATTA TTATTATTGC 2834 CATTTTATAA TTGAGGATGC TGAAACTCAG TGATTTTCTG GTGGTTACAT GGCTAAGGAA 2894 CTGGATTTCA ACGTAAGTTC CTTGGATCTA AGTCCAGTTC TCTTCTGACT ATATCACCCT 2954 TTTGTTATCA CCATGTATCT ACTTCTTTGG TCTCTGTTCA AATTTGCACT ACATCCCCTT 3014 GTTCCAGGAA GCCATTCAAG ACTGACTTTC TTAGTGCCTC TCACTACTTT CTGGAACTGA 3074 CATATGTTTT TCACTCTGTA TATACTTACA ATTAAATAGT CATAAATATT CAGAGCTTGG 3134 AGAAACCTTA TATTTCATCC AGTCCAGTAA ATTTATCCAT CCATAATTCA CTCATTCATT 3194 CACATAATAA ATATTTAATG TAACAATGGT TGAACATGGC AGACAGTGTT TCTACCTCAA 3274 AAGAGATTGC AGTCCTCATT TACAGATACT GAATTGAAAT TAACAGAAGT AGAGTGAGTC 3334 AGCTCAAATC ACATAGTGAA TTGGTTTCTT TGTTTTTAAA TCTCCTGCAT ATGTGTCCTG 3394 TCTTTCTCCC TGTGTTGGGC GTTCCCTGGG GCACCAATAC TAATTTCTCC TTCCCCTAGA 3454 AATCAAAACA GGGTCTTATC ACCAACAGAA TAAGGACAGG TTGACCACTG ATTGTCAGAA 3534 TATTGCTTCG TTTGTACTTT TAAGCCTAGA CAGTTTTCAA TGACTTTTTT TCTCTCTACA 3494 TGTCTTTTCA TATTTTTATC TTCTTGAAGT CCCTCAGAAA CCTAAGGTCT CCTTGAACCC 3554 TCCATGGAAT AGAATATTTA AAGGAGAGAA TGTGACTCTT ACATGTAATG GGAACAATTT 3614 CTTTGAAGTC AGTTCCACCA AATGGTTCCA CAATGGCAGC CTTTCAGAAG AGACAAATTC 3674 AAGTTTGAAT ATTGTGAATG CCAAATTTGA AGACAGTGGA GAATACAAAT GTCAGCACCA 3734 ACAAGTTAAT GAGAGTGAAC CTGTGTACCT GGAAGTCTTC AGTGGTAAGT TCCAGGGATA 3794 TGGAAATACA GATCTCTCAT GTGAGGGATG GCTCATCTGA AGATGGGAAA AAACAGGTTA 3854 TTCCAAGGGT TAGGACACCA GAGTGGGATT CAAGGCCTCT CATTTTTAAG ACCCCTGCAT 3934 TGGCTGGGCA CAGTGGCTCA CGCCTGTAAT CCCAGCACTT TGGGAGGCTG AGGCAGGTGG 3994 ATCACGAGGT CAGGAGATCG AGACCATCCG GCTAACATGG TGAAACCCCA TCTCTGCTAA 4054 AAAATATATA TATATAAAAT TAGCCGGGCG TAGTGGTGGG CACCTGTAGT CCCAGGTACT 4114 CGGGAGGCTG AGGCAGGAGA ATGGTGTGAA CCCAGGAGGT GGAGGTTG'CA GTGAGCTGAG 4174 ATCACGCCAC TGCCCTCCAG CCTGGGCTAC AGAGCAAGAC TCCGTCTCAA AAAATAAATA WO 00/09525 PCT/US99/17712 EPI-109 660 4234 AATAAATAAA AAAGACCCCT GCATCTCTTT TCTTCTACCC CCTTCCCTTT TGATTACTTG 4294 TATGCCTTCT TTCAATATTC TAGTCATCTC TCAATATTAT TCCTCCACCC TATTTTCCTC 4354 TATCTTTTCT GCCTAGATTC AGGTATATAT TATGTGGTCA AACAGCATCA CATATATGTG 4414 AACATTTCAA AGAGCTGTGT ATCTGGAATA GGATCAAAAG GTTTGACTTA AAGTTTTGCT 4474 CTGCATAATC CATATGGCAG GACCTCAATA TTAGGTTGTA CTCTTCGTTA TGAAACATAT 4534 CTGGGTACAT TTCCTTATGT CCTCTGTTGT TACTTAAGAA CACATATTTC ATGCTTGTTT 4594 CATTTTTATC ACTCCTACTG CCAACAAATA GCATAGCATC CTTAGGCACA TGTGGCTTAA 4654 TTAGCAAATG TTGAATAAAC AAATTAATGA TTTTGAATAG TGACCAATAG GTCTCTTTTA 4714 TACTCTATAT TTTTCTCTTG AGTGAAAAAA AATGTTTCAA CCTCCATATG TAAATTCCAA 4774 ACACAAACTA AAGCAATGTA GAATAGCTTC TTTATTCCCT GGAGTAGGTT CTAGAGAAGT 4834 CCTAAAGGAT TGGTCCTAAA TTAATTATGC TTATTATGCT AGCGATATTT CCTTTCAAAA 4894 TTCTCCTTTA ATGAATGCTT TTTAATTTTT ACAAAAGCAT TAACCATAGA ATGTGATTCT 4954 TGTCTTTCAC TGACTCATTA GTGACAAATA TTTGTTGAGT ACCTACCAAC TCCTAAGTAT 5014 TGCTACCAAC TCCTAAATAC TGTGTTGGGC ATTCAGAATA GAATGTAGAA CTAGACAGGG 5074 TCCCTGACTT CTTGGAGCAC AGAGCAGTAT GGGAAGAGGA CATTAAATAA AGAATTACAT 5134 AAGTAATTAA TTTAAATTAT ACATGTTTTG AAGAAGTTTT TTTTTGACAA CTATAATTAA 5194 CACTAGAACT GGGAAGTTTC TATAAGGTAA GAGAGGACAA AATAGACACT CTCCTAAGCT 5254 AAAATTCCCA AGAAAGACTG TTTATTTTCC CCTAACTAAC TAGAACTAGC AACAGAAGAT 5314 CTGAAAGGAA TTCTGGCTTT CAAGTGTTCC ATGTATGGAC TCATCAGGGA GGTCCGAGAG 5474 GCTTTGTGGC CCCAGACTGA CTTTTCAGGA GGGGAAAGGA TTTATCAATA CACAAGACAG 5534 GCTCTAAGCA TTATTTTGTG CCCTTTAAAA ATCCACTTTA TGAGCCAAAA AGTGAGTTAA 5594 TGATAATTCA TAGTTTCTGA CACATGCTCT ATGCGTGGCT CTCTTTTCTC TATTCATTCT 5654 CTCTCTCTTC ATTTATTCTT AAATAAATAA TGTAATGAAT GTTCTTCAGA CTGGCTGCTC 5714 CTTCAGGCCT CTCCTGAGGT GGTGATGGAG GGCCAGCCCC TCTTCCTCAG GTGCCATGGT 5774 TGGAGGAACT GGGATGTGTA CAAGGTGATC TATTATAAGG ATGGTGAAGC TCTCAAGTAC 5834 TGGTATGAGA ACCACAACAT CTCCATTACA AATGCCACAG TTGAAGACAG TGGAACCTAC 5894 TACTGTACGG GCAAAGTGTG GCAGCTGGAC TATGAGTCTG AGCCCCTCAA CATTACTGTA 5954 ATAAAAGGTG AGTTGGTAAA GGAAAGGAAA AGCATCCATA GCAGGGGAAG GAAGAGAGAA 6014 CTTCTGAGCC TGAGCAGTTG CAGCTTGTAG AAGGGGGGCA CCTGTGATAC ACTGGAAAGC 6074 CTACCAGACT TGCAATGAGG AGACCTGGGT GATAGTATAT ATCTCAATCT CTGTTTCAAA 6134 GCCTTGACTT GTTAAATGGT GATAGTAATA CCTGCTTGCA CTATGAAATT TTTATGAAGA 6194 TTAATGTGGT AATATTTGTG AAATGACTTT GTAAACTGTT AAGCACTACC CAAGCATAAC 6254 AGATTGTGAT TACTATTTTG ATCTCAAAGT CATCTGTTGC TCCTGGGGGA ACACTTATAT 6314 TTATCAAATT GAAAAAAGT TTCAAAGTTG AATGAAGAAA GGATATAAAG AGCTTGAGGA 6374 GCCCATTCCA GCTTAGGAGG GCTGGGAAAG GAAACCAGCA AGTCAGTAAG CTGTGTGCCT 6434 GTGTATTGAG GGAGGAGGGA ATGGACTTGA TATGGAGAGG GTAGGGAGGT GGACTGCCTC 6494 TATGGCCTGT AAGAAAAACT GCTCTCTCCA AACTCTTTAT AAGAGAGGGA GCCTGTGAAG 6554 TATTCACTTT TGAAGGAGAA AGTTAGACTT TTCCTTCACA CACTTTGTAC ATAATAATGT 6614 TTAAAAAAGC ATGAGGTCAA AATACATAAT TAAGTCCTAG CAGTTCTCTG TTAACTAATT 6674 TGAGACTGAA GTGCTATGTA CTTGTCTCTA GGCTTCCAGT ATCTTCATCT GTAAAACAGA 6734 ATATTTGGTC TAGATTCCAT TAGAATCATT TGATAACTTA AAAAATATAT TGATGCTCAT 6794 GTCTCATTTC TTGAGATTCT GATTTAATTG GTTTGGGGTG CAGCCTGGGT ATACGTATTT 6854 TTCATAGGTC TTTCACATAA TGGTAATGGG TAGCCAATAT TGAGAATCAC TTGTCTAGGT 6914 GATCTTTAAA TGATTTCTGG ATGTAATATT CTGAGGCTCT ATAATTTGAG ACTAATCACA 6974 AAAATCGGTA CAGTTTATAA ACAGACTAAC AGAACCACAA AATAATAGAA TTGGAAGGCA 7034 ATTTAACTAG TGCAATTTCT TCATTTTGCC TAACAGGCAT GTAAGAAATG ATGATTGATT 7094 GAGTAATAGG CATTGATGAC CCCTGTCCTC ACTTTGTCCC CTTTCCACCC CTTAATTATA 7154 TGTGAATTCT GGTCTTGTCA TTTCGAATAA GGGGTTTATC TTTCCTATTG TCTTCCCCTC 7214 TGGGCACGGC ACACTGGCTA CTGGAGTTAA GAGGAAATGC TTAGGACTCC CTGTGGCTCC 7274 AGGGAGCACC AACAGAGCAA CTCAACCTAG TGTTAATCTG AGTGTTTTCT CTGTGCTTCT 7334 GGATGCCACA TCACGCTAAA AATGAAGGAC AAAGCTTGGT CTTTCTCTTA GGGAGGATGA 7394 AACTCTGAAC CTCATTTTTC AGTTCCCAAG ATGAATTATG TTTCTCATTG CATCTGTGTT 7414 CCACTACAGC TCCGCGTGAG AAGTACTGGC TACAATTTTT TATCCCATTG TTGGTGGTGA 7474 TTCTGTTTGC TGTGGACACA GGATTATTTA TCTCAACTCA GCAGCAGGTC ACATTTCTCT 7534 TGAAGATTAA GAGAACCAGG AAAGGCTTCA ACTTCTGAA CCCACATCCT AAGCCAAACC 7594 CCAAAAACAA CTGATATAAT TACTCAAGAA ATATTTGCAA CATTAGTTTT TTTCCAGCAT 7654 CAGCAATT C TACTCAATTG TCAAACACAG CTTGCAATAT ACATAGAAAC GTCTGTGCTC 7714 AAGGATTTAT AGAAATGCTT CATTAAACTG AGTGAAACTG GTTAAGTCC ATGTAATAGT 7774 AAGTGCTCAA TTAACATTGC TTGAATAAAT GAGAGAATGA ATAGATTCAT TTATTAGCAT 7834TTGTAAAAGA GATGTTCAAT TTCAATAAAA TAAATATAAA ACCATGTAAC AGAATGCTTC 7894 TGAGTATTCA AGGCTTGCTA GTTTTTTGT TTGTTTTCTA CTAAAGGCAA GGACCATGAA 7954 GTTCTAGATT GGAAATGTCC TCTCTTGACT ATTGCAAGTG CGATCTAGA ATGAAAAGAC 8014 ATAGGAGGAT GCCAGTGAGG TGGATCATTT TTATGCTTCT TCTTCAGCTT ACTAAATATG 8074 AACTTTCAGT TCTTGGCAGA ATCAGGGACA GTCTCAAGAC ATAGGACTCT CAGGATGAAG 8134 TAGAGTCCAG GATTCCTCTG TGATTGTTTT GCCCCTCCCA AATTTATATC TTGAACTTAT 8194 GTCTTGTATC TTTATACAGC ACCTGAACCA AGCATTTTGG AGAAATTCCA GCTAATAATA 8254 ATAACCAAAA CCTTCGGCTC TGAAAACAGT CCAGGACTGA ATAAGATCTT GGGCAAAAGA 8314 ACTAGACAGT TTTGGTTTAT TTTCCCTTTC ATTTTATGTC TTCATCATAG TCATTGGAGG WO 00/09525 PCT/US99/17712 EPI-109 661 8374 CTCATTCTTC TTGTCATGGA GTAAATGGGA TTAAAGTTC 8413 TACTAAGAGT CTCCAGCATC CTCCACCTGT CTACCACCGA GCATGGGCCT ATATTTGAAG 61 CCTTAGATCT CTCCAGCACA GTAAGCACCA GGAGTCCATG AAGAAGATGG CTCCTGCCAT 121 GGAATCCCCT ACTCTACTGT GTGTAGCCTT ACTGTTCTTC GCTCCAGATG GCGTGTTAGC 181 AGTCCCTCAG AAACCTAAGG TCTCCTTGAA CCCTCCATGG AATAGAATAT TTAAAGGAGA 241 GAATGTGACT CTTACATGTA ATGGGAACAA TTTCTTTGAA GTCAGTTCCA CCAAATGGTT 301 CCACAATGGC AGCCTTTCAG AAGAGACAAA TTCAAGTTTG AATATTGTGA ATGCCAAATT 361 TGAAGACAGT GGAGAATACA AATGTCAGCA CCAACAAGTT AATGAGAGTG AACCTGTGTA 421 CCTGGAAGTC TTCAGTGACT GGCTGCTCCT TCAGGCCTCT GCTGAGGTGG TGATGGAGGG 481 CCAGCCCCTC TTCCTCAGGT GCCATGGTTG GAGGAACTGG GATGTGTACA AGGTGATCTA 541 TTATAAGGAT GGTGAAGCTC TCAAGTACTG GTATGAGAAC CACAACATCT CCATTACAAA 601 TGCCACAGTT GAAGACAGTG GAACCTACTA CTGTACGGGC AAAGTGTGGC AGCTGGACTA 661 TGAGTCTGAG CCCCTCAACA TTACTGTAAT AAAAGCTCCG CGTGAGAAGT ACTGGCTACA 721 ATTTTTTATC CCATTGTTGG TGGTGATTCT GTTTGCTGTG GACACAGGAT TATTTATCTC 781 AACTCAGCAG CAGGTCACAT TTCTCTTGAA GATTAAGAGA ACCAGGAAAG GCTTCAGACT 841 TCTGAACCCA CATCCTAAGC CAAACCCCAA AAACAACTGA TATAATTACT CAAGAAATAT 901 TTGCAACATT AGTTTTTTTC CAGCATCAGC AATTGCTACT CAATTGTCAA ACACAGCTTG 961 CAATATACAT AGAAACGTCT GTGCTCAAGG ATTTATAGAA ATGCTTCATT AAACTGAGTG 1021 AAACTGGTTA AGTGGCATGT AATAGTAAGT GCTCAATTAA CATTGGTTGA ATAAATGAGA 1081 GAATGAATAG ATTCATTTAt TAGCATTTGT AAAAGAGATG TTCAATTTCA ATAAAATAAA 1141 TATAAAACCA TGTAACAGAA TGCTTCTGAG TAAAAAAAAA AAAAAAAAAA AAAAAAAA 1 TCTCAATATA ATAATATTCT TTATTCCTGG ACAGCTCGGT TAATGAAAAA ATGGACACAG 61 AAAGTAATAG GAGAGCAAAT CTTGCTCTCC CACAGGAGCC TTCCAGTGTG CCTGCATTTG 121 AAGTCTTGGA AATATCTCCC CAGGAAGTAT CTTCAGGCAG ACTATTGAAG TCGGCCTCAT 181 CCCCACCACT GCATACATGG CTGACAGTTT TGAAAAAAGA GCAGGAGTTC CTGGGGGTAA 241 CACAAATTCT GACTGCTATG ATATGCCTTT GTTTTGGAAC AGTTGTCTGC TCTGTACTTG 301 ATATTTCACA CATTGAGGGA GACATTTTTT CATCATTTAA AGCAGGTTAT CCATTCTGGG 361 GAGCCATATT TTTTTCTATT TCTGGAATGT TGTCAATTAT ATCTGAAAGG AGAAATGCAA 421 CATATCTGGT GAGAGGAAGC CTGGGAGCAA ACACTGCCAG CAGCATAGCT GGGGGAACGG 481 GAATTACCAT CCTGATCATC AACCTGAAGA AGAGCTTGGC CTATATCCAC ATCCACAGTT 541 GCCAGAAATT TTTTGAGACC AAGTGCTTTA TGGCTTCCTT TTCCACTGAA ATTGTAGTGA 601 TGATGCTGTT TCTCACCATT CTGGGACTTG GTAGTGCTGT GTCACTCACA ATCTGTGGAG 661 CTGGGGAAGA ACTCAAAGGA AACAAGGTTC CAGAGGATCG TGTTTATGAA GAATTAAACA 721 TATATTCAGC TACTTACAGT GAGTTGGAAG ACCCAGGGGA AATGTCTCCT CCCATTGATT 781 TATAAGAATC ACGTGTCCAG AACACTCTGA TTCACAGCCA AGGATCCAGA AGGCCAAGGT 841 CTTGTTAAGG GGCTACTGGA AAAATTTCTA TTCTCTCCAC AGCCTGCTGG TTTT 1 AAGCTTTTCA AAGGTGCAAT TGGATAACTT CTGCCATGAG AAATGGCTGA ATTGGGACAC 61 AAGTGGGGAC AATTCCAGAA GAAGGGCACA TCTCTTTCTT TTCTGCAGTT CTTTCTCACC 121 TTCTCAACTC CTACTAAAAT GTCTCATTTT CAGGTTCTGT AAATCCTGCT AGTCTCAGGC 181 AAAATTATGC TCCAGGAGTC TCAAATTTTC TTATTTCATA TTAGTCTTTA TTTAGTAGAC 241 TTCTCAATTT TTCTATTCAT CACAAGTAAA AGCCTGTTGA TCTTAATCAG CCAAGAAACT 301 TATCTGTCTG GCAAATGACT TATGTATAAA GAGAATCATC AATGTCATGA GGTAACCCAT 361 TTCAACTGCC TATTCAGAGC ATGCAGTAAG AGGAAATCCA CCAAGTCTCA ATATAATAAT 421 ATTCTTTATT CCTGGACAGC TCGGTTAATG AAAAAATGGA CACAGAAAGT AATAGGAGAG 481 CAAATCTTGC TCTCCCACAG GAGCCTTCCA GGTAGGTACA AGGTATTATT TTTTTCTACC 541 CTCAGTCACT TGTGGCAGGG GAAGTCATAG TCACGGTGCT TAGGAGATGA AACTTTATTG 601 ATTTAGGCAT GGATCCATCT AGTTTAATTA ATATATTGGG TATGAGGAAG CTACTTGCTG 661 TACTTTCCAT GTGGTTCTCT CTCCCTGGAG AGGAACATTT TTACTCAGCT TGCAAACTGG 721 AAATAGATTT TCTCACATTA GAAGCTCATT TTCTGGGTAT GAGACAGGAG AGTTCATACT 781 GTGTATGTAG ATCTCTGGCT TCTGGGTCTG ACATGTGCTG AGGGACACAT ATCCTTCACA 841 CATGCTTTTA TAAATACTTG ATAAAGTAAC CTGCTTCTTG ATTGGTCTTT ATAATCCATA 901 AGCTGTGGGA TGCTTCTCTG AAGATGAAAA TAGTAATAGA GTCCCATCTA GCTATTCAAA 961 GCCATTCCTT CATTGTATTC TGTGCACATG AAGTTGGGGT TTGTTACTGA CAAAATATAT 1021 TCAGATACAT TTCTATGTTA AAAGGATTGT GAGATGCATA GGTAAATGTG TTTATTTTCA 1081 GTTTTACTTG TCAACATAGA TGAATGAGAA AGAACTTGAA AGTAACACTG GATTAAGAAT 1141 AGGAAAATTT GGCATGGATT TTGCTCCATT TTGTCCCATC TAATCACTTG GATAGTGTTC 1201 AGGTGTTCTT GGTCAGTTAC TTGGATGCTC TGAGCTTTAG TTTCTTGGTG ATTACAATGA 1261 AGATTTGAAT TACAGGATGG CTTTGAAAAA ATAAACAAAA CTCCCCTTTC TGTCTGTCGA 1321 GAATGTTGCA CAGGGAGTTA CAGAATGTTC TCATGACTGA ATTGCTTTTA AATTTCACAG 1381,TGTGCCTGCA TTTGAAGTCT TGGAAATATC TCCCCAGGAA GTATCTTCAG GCAGACTATT 1441 GAAGTCGGCC TCATCCCCAC CACTGCATAC ATGGCTGACA GTTTTGAAAA AAGAGCAGGA 1501 GTTCCTGGGG GTGAGTGAGC CTCCTCCAAC TTTGACTAGA GTAAGGGTTG GGTCTAGAAA 1561 AGAATATTGA GTTGCATCAA CTGTTTTCCC ACTTGGATTC ATGAGAGGTG TTAGGTCCTT 1621 TAAAAAACAT GGTAGATAAA GAGTTGACAC TAACTGGGTC CTTTTGGGAA GAGCCAGAAG 1681 CATTTCCTCA TAAAGACTTT AAATTGCTAG GACGAGAATG GCCAACAGGA GTGAAGGATT 1741 CATAACTTTA TCTTTACTTA GATGTAAAGA ACAATTACTG ATGTTCAACA TGACTACATA 1801 CATAAAGGCG CATGGAGAAA AGTATTGGCC TTCCATGCAT TAGGTAGTGC TTGTATCAAT 1861 TCTTATAGT GCTAGGGTAT CCTGGAAAAT CTTACGTGTG GATCATTTCT CAGGACAGTC WO 00/09525 PCT/US99/17712 EPI-109 662 1921 TAGGACACTA ACGCAGTT.C TCATGTTTGG CTTCTATTAT TAAAAAATGA TACAATCTCG 1981 GGAAAATTTT TTTGATTTTC ATGAAATTCA TGTGTTTTTC TATAGGTAAC ACAAATTCTG 2041 ACTGCTATGA TATGCCTTTG TTTTGGAACA GTTGTCTGCT CTGTACTTGA TATTTCACAC 2101 ATTGAGGGAG ACATTTTTTC ATCATTTAAA GCAGGTTATC CATTCTGGGG AGCCATATTT 2161 GTGAGTATAT ATCTATAATT GTTTCTGAAA TAACACTGAA CATAGGTTTT TCTCTTTCTC 2221 AGATCTAACC AGTTGTTTAT TCCCAGTATT AAGATGATAT TTATAATTCT TAATTATAAA 2281 TATATGTGAG CATATATAAC ATAGATATGC TCATTAACAA CAACAAAAGA TTCTTTTTAC 2341 AATTAACGGT GGGTTAAACA TTTAGCCCAC AGTTTTATCC CATGAGAAAC CTGAATCTAA 2401 TACAAGTTAA ATGACTTGCC TAAGGGCCAC TTGACTAATA GTAATTGAAC CTAAACTTTC 2461 AGAATCCAAC TCCAGGAACA TACTTCTAGC ACTATTCATC AATAAAGTTA TATGATAAAT 2521 ACATACAACT TTATCTGTCA ACTAAAAATA ACAACAGAGG CTGGGCATGG TGGCTCACAC 2581 CCGTAATCCC AGCACTTTGG GAGGCTGAGG CAGGTGGATC ACCTGAGGTC AGGAGTTTGA 2641 GACCAGCCTG ACCAACATGG TGAAACCTCA TCTCTACTAA ATATAAAAAA TTAGCTGAGT 2701 GTGATAGTGC ATACCTGTAA TCCAGCTACT TAAGAGGCTG AGGCAGGAGG CTTGTTTGAA 2761 CCTGGAAGGC AGAGGTTGCA GTGAGCTGAG ATTGTGCCAT TGCACTCCAG CCTGGGCAAT 2821 AAGTGCGAAC TCTGTCTCAA AATAATAATA ATAATAATAG AAAATAAAGT TGTCTTCATG 2881 AAAAATGAGG AAAGAGATTG CTGGGGTGAG AAACATTAAG ATCAATGGGC ATATGGTGAC 2941 CTTCTATGCC CTAGAAACTC TTTTANGGTA TTTTCTCCTG GTATCTCTTT TACNCATCGT 3001 TCTATCTGGA AAAATAGGTG GATGAGTGAG ATAATAACGG TATATACTTT TTAAAGGTCT 3061 AATTGACATA TATAAATTGC AAGTATTTCA GATGTCAATT TGCTAACCTT GACACACATA 3121 GACACACATG AAAACATCAC CACATTAATA CAATGTATGT ATCCATCATT CCAAAAGCTT 3181 CCCTGTGTAT CTTTGTAACT CTTTCTTCCT CCCTCCACTC CTTGTCCTCT CGTTCCCAAG 3241 AAAACATTGA TCTGCTTCCT GTGAATATAA ATTAACTTAC ATTTTTTAGA GCTTTATATA 3301 AGTATGTTCT CTTTACTGTT TGTCTTCCTT CGCTGCACAG TTATTTTGAG ATTCTTCAAG 3361 TTTTTTCTTT ATATCGATAC TTCATTCACA AGAATATATT TTAATTCTAG ACTATGTCAC 3421 ATTGACTTTG TCGTCTGCTA AATCCTTAGT GCTCAGATGA CTTGTTCAGG ACTCTCCTTG 3481 AACCTGTACC TCTGTTAAT TGAAACTTGT CTCTACTGTC TTTTTATTTC AAACACAGCT 3541 TATTAGGTGT CTCTCAACCC ATCAAACNCA CAATCTGAGT CTTTAGGAGA TTGCTTTGAA 3601 TTTGTGCTAT TGACTTATAT NTATATNAAA TNTGTAAATG TTTGGTAAAA ATATCATCAT 3661 GTACNTTTTC ATAATTACGC TATNTNCACA TGATATATGT CAGACTCTGG AAATATGCAT 3721 GCCACAGACA CGTGTTTCTT GCCTAAAGGG GCTGATGGAA GACNCACATA CNAATAGACG 3781 ATTGCAGTAG AATGAGAGTG GTGGTCTAAN CAGTACATGT CCTGATGTTG CTCGGACAGT 3841 TACTACNCCA AGAGTACCCC CTGCATTGTC AGGGTTAGCA TCTCCTGGAA GCCTCATGTA 3901 AATGAAGAAT TTCATGCTCC ATCCAGGACC TAATGAATAA GAATCTGCAT TTTAGCAAGA 3961 CCCTCATATG ATTCATATAC ACTTTTTTTT TTTTTTTTTA GATGGAGTCT CACTCTTGTC 4021 GCCCAGGCTG GAGTGCAATG GCATGATCTT GGCTCACTGC AACCTCTGCC TCCCGGGTTC 4081 AAGTGATTCT CCTGTCTCAG CCTCCCTAGT AGCTGGGACT ACAGGTGCAT GCCACAGTGG 4141 CTGGCTAATT TTTGTATTTT TAGTAGAGAC AGGGTTTCAC CATTTTGGTC AGGCTGGTCT 4201 TGAACTCATG ACCTCCGGTG ATTCCCCCGC CTCGGCTTCC CAAAGTGCTG GGATTACAGA 4261 CATGAGCCAC CACACCCGCC TTATTCGTAT ACNCATTTAA TTCTGAGAAG CACTCTATAG 4321 AAAATAAGAA TAAGAAAATA TTGGGCTCAC AGGTGACATT AATAAGTAAC TTTATCGAGT 4381 ACCCCAAATT TTACCTATGT TTGGAAGATG GGGTTAAAAG GACACATTGA AAACAAGAAC 4441 TCATTGTGGC TTTTTTTTCC TCCTTTTTGA ACAGTTTTCT ATTTCTGGAA TGTTGTCAAT 4501 TATATCTGAA AGGAGAAATG CAACATATCT GGTGAGTTGC CCGTTTCTGT CTTTGTCCAT 4561 CCTTGAAAAG ATAAGAAGAA CAGAGTTTTA AGAGTCTTAA GGGAAACACA TCTTTGTCTC 4621 CTATATTACT TGTGAATGTG GATATATGAT TTTGTTTCAA TCTATTTTGT GTCCTAAGGC 4681 TTTTTGCAAC AGAAGTTGGA TATATCATTA GAAACATAAA TTGTACCATT TAACATACAT 4741 GAAGTTTATG TTTACCTTGA CGTTCTTCTA AAAAGTGTCC TACACCGGCA TTGTCCTTGT 4801 AGGCATATTC ACATGATCAA ATAAAATAAT TAGTTTTCAA TTAAGGAGAA TATTTGAGGA 4861 AAGACCGTAC GTGTTCATGT GGTTCCTGAA GGCAGTCCAG TGAGAAAGTA ATATATGCTT 4921 CATTAAACAA TGCGGACATT TTCAGGGTTT CCCTTTTTAA CCAAAATTTG GAAGCAATGT 4981 GGAATTTACT GGATGCATCC AGCCCTGAAA TGAAGATAGG TTTATTGAAT GTGCCAGCAA 5041 GTGCAGGCCC AGGTCTGAGT GTTCTTCATT ATTATCAGGT GAGAGGAAGC CTGGGAGCAA 5101 ACACTGCCAG CAGCATAGCT GGGGGAACGG GAATTACCAT CCTGATCATC AACCTGAAGA 5161 AGAGCTTGGC CTATATCCAC ATCCACAGTT GCCAGAAATT TTTTGAGACC AAGTGCTTTA 5221 TGGCTTCCTT TTCCACTGTA TGTATTTTTT TTTGTGTGGG AAGACTAAGA TTCTGGGTCC 5281 TAATGTAAGT AAGAAGCCCT CTTCTCCTGT TCCATGAACA CCATCCTTTT CTGTAACTTC 5341 TATTACACAG TATAGTGGTT CTGTAAGTTC ACACAGCCCA GGGAGATGCT GGCTGCCCAC 5401 TCCCCTCAAC CCAGGCAAAT TCCTCGGGGT TAAAGTTATC TACTGCAAGT GACGATCTCT 5461 GGGTTTTTCT GTGCCTGTGT TTGTGTGTGT GTGTGTGTGT GTGTGTGTGT GTATGTGTCA 5521 CTTTAAAAGG ACTGGTCAGA TTGTAGGGAG ATGAAAACAG GAGATGCTAT AAGAAAATAA 5581 ACTTTTGGGG CGAATACCAA TGTGACTCTT TTTGTTTGTC ATTTGTTGCT GTTCAATAGG 5641 AAATTGTAGT GATGATGCTG TTTCTCACCA TTCTGGGACT TGGTAGTGCT GTGTCACTCA 5701 CAATCTGTGG AGCTGGGGAA GAACTCAAAG GAAACAAGGT AGATAGAAGC CCGATATAAA 5761 ATCTTGAATGC ACAGGTTAAC GAATTGGAGC TTTATTCCTT AAAATATGGC CTGGGTTTTC 5821 TGAAACATTT CTTCCAGAAA ATAGTTTCTC CAAGTTTTAT TACTTTGGTT TACAAATCTC 5881 ACATTTAAAT CACATTTTAT ACCATAAGTA GCACACATTT CATAATATTC CTCTGAATGA 5941 GGGTTGGGAT AATAGGACTG ATATGTTAGA AATGCCTTAA AGTGTGTGGA GCATGAGAGA WO 00/09525 PCT/US99/17712 EPI-109 663 6001 TGGATGTACA GAAGGCTTGT GAGGAAACCA CCCAGGTATC TGGCCTTGTT TTCTGCCCCA 6061 GAACTAGCCG CCTATTCCTG TTTCTGTTTT ATTCCTTTGT TTCTTGACTT TTCCTTTCCA 6121 ACTTGCTCTA AAACCTCAGT TTTCTTTCCT TTCTGATTCA TGACTACCAA ATGTTTTCAC 6181 TTGCCTCACC CGTCCATTAC ACCTTTGATA AGAACCACCA GACCTTGTGC TCATGTACTT 6241 GCCCATGTCT GATGGAAGAA ACATACTCTC TCCATCTGTC CACTTTCCTG AGGCATTCAA 6301 GTCTAGCCAC CTTTTAAAAT CACTCTCCTC CAGGCTGGGC ACGGTGTCAC GCCTGTAATC 6361 TCAGCACTTT GTGAGGCTGA GGAGGGCGGA TCACTTGAAG TCAGGAGTTC AAAACCAGCC 6421 TGGCCAAATG GCAAAACCAA ATCTTCTTCA ATTATAACCA AATCTTAAAC CAAATCTCTA 6481 CTAAAAAATA CAACAAAACA AAACAACAAC AACAAAAACA GAAAAGGAAA CATTAGCCCA 6541 GCGTGGTGGC AGGTACCTGA GGTTCCAGAT ACTTGGGAGG CTGAAGCAGG AGAATCGCTT 6601 GAGCCCAAGA GATGGAGGTT GCAGTGAGCC GAGATCATGC CACTGCACCA CAGCCAGGGT 6661 GACAGAGCCA TACTTCCCAG CACATTGGGA GGCCAAAGCT GAAGAATAAT TTGAGGTGAG 6721 GATTTGGAGA CCAGCCTGGC CAACATGGTG AAACTCCGTC TGTACTAAAA ATATAAAACT 6781 TAGTGGGGCA TGGGGGCACA CACCTGTAAT TTCAGCTACT TAGGAGGCTG AGGCAGGAGA 6841 ATTGCTTGAA CCCGGGAGGC GGAAGTTGCA GTGAGCCAAG ATCGTGGCCA CTGCACTCCA 6901 GCCTGGGTGA CATAGTGAGA TTCTGTCTCA AAAAAAATAA AAGAAATTTA AAAAATCACT 6961 CTCTTCCAAA GATAGATAAA TAAGACAGCA GATATACTAA GGAATAACCT CACCAACTTG 7021 TCATTGACTG ACATGATTTC TTTTGGCCCA CTTGGCCAGC TAGTCTGGTT TGGTTTTCTG 7081 GAAATGAAAG AAATAATCAG AGTTTAATGA CAGAGAGCGT GAGACCCAGA AAGACAAAAG 7141 TAGATGAGGT AAGTCTCTTG AGCGAGACTT CTAGGGATGG GAAATTTGTG GTGATTGATA 7201 TGAAATGATT TTTCCCTTAT CAGGTTCCAG AGGATCGTGT TTATGAAGAA TTAAACATAT 7261 ATTCAGCTAC TTACAGTGAG TTGGAAGACC CAGGGGAAAT GTCTCCTCCC ATTGATTTAT 7321 AAGAATCACG TGTCCAGAAC ACTCTGATTC ACAGCCAAGG ATCCAGAAGG CCAAGGTTTT 7381 GTTAAGGGGC TACTGGAAAA ATTTCTATTC TCTCCACAGC CTGCTGGTTT TACATTAGAT 7441 TTATTCGCCT GATAAGAATA TTTTGTTTCT GCTGCTTCTG TCCACCTTAA TATGCTCCTT 7501 CTATTTGTAG ATATGATAGA CTCCTATTTT TCTTGTTTTA TATTATGACC ACACACATCT 7561 CTGCTGGAAA GTCAACATGT AGTAAGCAAG ATTTAACTGT TTGATTATAA CTGTGCAAAT 7621 ACAGAAAAAA AGAAGGCTGG CTGAAAGTTG AGTTAAACTT TGACAGTTTG ATAATATTTG 7681 GTTCTTAGGG TTTTTTTTTT TTTTAGCATT CTTAATAGTT ACAGTTGGGC ATGATTTGTA 7741 CCATCCACCC ATACCCACAC AGTCACAGTC ACACACACAT ATGTATTACT TACACTATAT 7801 ATAACTTCCT ATGCAAATAT TTTACCACCA GTCAATAATA CATTTTTGCC AAGACATGAA 7861 GTTTTATAAA GATCTGTATA ATTGCCTGAA TCACCAGCAC ATTCACTGAC ATGATATTAT 7921 TTGCAGATTG ACAAGTAGGA AGTGGGGAAC TTTTATTAAG TTACTCGTTG TCTGGGGAGG 7981 TAAATAGGTT AAAAACAGGG AAATTATAAG TGCAGAGATT AACATTTCAC AAATGTTTAG 8041 TGAAACATTT GTGAAAAAAG AAGACTAAAT TAAGACCTGA GCTGAAATAA AGTGACGTGG 8101 AAATGGAAAT AATGGTTATA TCTAAAACAT GTAGAAAAAG AGTAACTGGT AGATTTTGTT 8161 AACAAATTAA AGAATAAAGT TAGACAAGCA ACTGGTTGAC TAATACATTA AGCGTTTGAG 8221 TCTAAGATGA AAGGAGAACA CTGGTTATGT TGATAGAATG ATAAAAAGGG TCGGGCGCGG 8281 AGGCTCACGC CTGTAATCCC AGCCCTTTGG GAGGCCGAGG TGGGCAGATC ACGAAGTCAG 8341 TAGTTTGAGA CCAGCCTGGC CAACATAGTG AAACCCCGTC TCTACTAAAA ATACAAAAAA 8401 AAAATTAGCT GGGTGTGGTG GCAGTCACCT GTAGTCCCAG CTACTTGGGA GGATGAGGCA 8461 GGAGAATCGC TTGAACCTGG GAGGCGGAGG TTGCAGTGAG CCGAGATCGC ACCAGTGCAC 8521 TCCAGCCTTG GTGACAATGG GAGACTCCAT CTCAAAAAAA AAAAAAAAAA AAAAAAGATA 8581 AAAAGTCAGA AATCTGAAAA GTGGAGGAAG AGTACAAATA GACCTAAATT AAGTCTCATT 8641 TTTTGGCTTT GATTTTGGGG AGACAAAGGG AAATGCAGCC ATAGAGGGCC TGATGACATC 8701 CAATACATGA GTTCTGGTAA AGATAAAATT TGATACACGG TTTGGTGTCA TTATAAGAGA 8761 AATCATTATT AAATGAAGCA AGTTAACACT CTAAGAGAAT TATTTTGAGA TAGAAGTGAA 8821 GCTAAGCTAA ACTTCACATG CCTATAATTG GAGGGAAAAA CTAAGGATAA AATCTAGCCT 8881 AGAAGATACA ATAATTAGTC ATAAACATGC ATTGTGAAAC TGTAGAGAGC AGGTAGCCCA 8941 AAATAGAGAA AGATTAGATA AAGAGAAAAT AAGTATCCAT CAGAGACAGT ATCTCTAGGC 9001 TTGGGCAAGA GAAAAGTCCA CAGTGATAAG CAACTCCACC TAAGGCATGA ATATGCGGCA 9061 GAGAAAACAG CAATAGTGAA TGAATGCAAA AGGTGCTGAG CAAATTCCAC ACATGAGTAT 9121 TGTGCATGAG TAAATGAATA AAACATTTGC AAAGACCTTT AGAGAAAGAG AATGGGAGCA 9181 TATGTGCGAA ATAAGATAGT TGATTATGAA TAGAAGGTAG TGAAGAAAAG CAAGCTAAGA 9241 AAAAATTCTG TTTATAAAAG AAGGAAAAGA TAGTTTATGT TTTTAGCCTA AGTATAAGAG 9301 TCCTACAGAT GGACTGAAAA AAATCAGTCT GAGAGTATTA GTCACAATTA ATGAAATAAT 9361 TACATTTTAT GTATTGAGGA TGCCAAGATT AAAAGGTGAC AGGTAGATGT TAATTTCCCT 9421 AGATTGTGAA AGTGATCACG ACAATCACAC AACAAATAAT TAAGTGACTT GGTATGCTTT 9481 ATTTAATTGT AGGGCCTGAG GTTTTCCATT CTCATTTTTC TAAAATACAA TTTTGTTTCT 9541. CCAAATTTGA CAGCAGAATA AAAACCCTAC CCTTTCACTG TGTATCATGC TAAGCTGCAT 9601 CTCTACTCTT GATCATCTGT AGGTATTAAT CACATCACTT CCATGGCATG GATGTTCACA 9661 TACAGACTCT TAACCCTGGT TTACCAGGAC CTCTAGGAGT GGATCCAATC TATATCTTTA 9721 CAGTTGTATA GTATATGATA TCTCTTTTAT TTCACTCAAT TTATATTTTC ATCATTGACT 9781 ACATATTTCT TATACACAAC ACACAATTTA TGAATTTTTT CTCAAGATCA TTCTGAGAGT 9841 TGCCCCACCC TACCTGCCTT TTATAGTACG CCCACCTCAG GCAGACACAG AGCACAATGC 9901 TGGGGTTCTC TTCACACTAT CACTGCCCCA AATTGTCTTT CTAAATTTCA ACTTCAATGT 9961 CATCTTCTCC ATGAAGACCA CTGAATGAAC ACCTTTTCAT CCAGCCTTAA TTTCTTGCTC 10021 CATAACTACT CTATCCCACG ATGCAGTATT GTATCATTAA TTATTAGTGT GCTTGTGACC WO 00/09525 PCT/US99/17712 EPI-109 664 10081 TCCTTATGTA TTCTCAATTA CCTGTATTTG TGCAATAAAT TGGAATAATG TAACTTGATT 10141 TCTTATCTGT GTTTGTGTTG GCATGCAAGA TTTAGGTACT TATCAAGATA ATGGGGAATT, 10201 AAGGCATCAA TAAAATGATG CCAAAGACCA AGAGCAGTTT CTGAAGTCCT CCTTTTCATC 10261 AGCTCTTTAT CAAACAGAAC ACTCTATAAA CAACCCATAG CCAGAAAACA GGATGTAGGA 10321 ACAATCACCA GCACACTCTA TAAACAACCC ATAGCCAGAA AACAGAATGT AAGGACAATC 10381 ACCAGCCATC TTTTGTCAAT AATTGATGGA ATAGAGTTGA AAGGAACTGG AGCATGAGTC 10441 ATATTTGACC AGTCAGTCCT CACTCTTATT TACTTGCTAT GTAAACTTGA GAAAGCTTTT 10501 TTCTCTTTGT GAACCTCAGG TTTTACATCT GAAAATGAGA AATTTGGAAC AAAAGATTCC 10561 TAACTGGTCT TTCTGTTCCC ATATTCTGTG ATTTTTCAAT ATTTAGGATT TTTGGTAATC 10621 ACAATTACTT AGTTTGTGGT TGAGATAGCA ACACGAATCA GAACTATTTG GTGGACATAT 10681 TTTCAAAGGA GTAGCTCTCC ACTTTGGGTA AAGAAGTGAT GCNGGTCGTG GTGGCTCACG 10741 CCTGTAATCC CAGCACTTTA GGGAGGCCAA GGCGGGTGGA TCACGAGGTC AGGAGATCGA 10801 GACCATCCTG GCTAACACGG TGAAACCCCG TCTCTACTAA AAAATACAAA AAATTAGCCA 10861 GGCGTGGTGG CGGGCGCCTG TAGTCCCACG TACTCGGGAG GCTGAGGCAG GAGAATGGCA 10921 TGAACCAGGG AGGCGGAGCT TGCCGTGAGC CGAGATAGCG CCACTGCAGT CCCTCCTGGG 10981 CAAAAGAGCA AGACTGCGTC TCAAAAAAAA AAAAAAAAAA AAAAAAAGAA GTGTGTGGAG 11041 TAGCAGGACA CCTGCAACAA TAATATTTTT CTAAATCCCT CTGAAAAATG CTAATCAAAG 11101 GGTTTTTTTC CTAAAAATTG TCTTAGAAAT AAAATTTCCC CTTTGGGAGA CCGAGGCTGG 11161 CAGATCACGA GGTCAGGAGA TAGAGACCAC GGTGAAACCC CGTCTCTACT AAAAATACTA 11221 AAAATTAGCC GGGGNGTGGT GGTGGGTACA CCTGTAGTCC CAGCTACTTG GAGGCTGAGG 11281 CTGGAGAATC ACGTGAAC (2) INFORMATION FOR SEQ ID NO:2506: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1291 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2506: 1 CATATGTATG GGAATACTGT ATTTCAGGCA TTATAAGGAA TGAAATTATA GGCCGGGCAT 61 TGTGGCTAAC CCTTGTAATC CTAGCACTTT GAGAGGCTGA AGTGGGCAGA TCACTTGAGC 121 TTCAGAGTTC GAGACCAGCA TGGACAACAT GGTGAAACCC AGTCTCTACC AAAAACACAA 181 AAATATTAGC TGGGTGTGGT GGTGCATGCC TGTAGTCCCA GCTACTCAGG AGGCTGAGGT 241 GGGAGGATCG CTTGAGCCTG GGAGGCAGAA GTTGCAATGA GCAGAGATCG TGCCACTCCG 301 CTCCAGTCTT GGTGACAGAA TGAGACTCCA TCTCAAAAAT AAATAAATAA ATAAATAAAA 361 TAAATGAAAT GAAATTATAA GAAATTACCA CTTTTTCATG TAAGAAGTGA TCATTTCCAT 421 TATAAGGGAA GGAATTTAAT CCTACCTGCC ATTCCACCAA AGCTTACCTA GTGCTAAAGG 481 ATGAGGTGTT AGTAAGACCA ACATCTCAGA GGCCTCTCTG TGCCAATAGC CTTCCTTCCT 541 TTCCCTTCCA AAAACCTCAA GTGACTAGTT CAGAGGCCTG TCTGGAATAA TGGCATCATC 601 TAATATCACT GGCCTTCTGG AACCTGGGCA TTTTCCAGTG TGTTCCATAC TGTCAATATT 661 CCCCCAGCTT CCTGGACTCC TGTCACAAGC TGGAAAAGTG AGAGGATGGA CAGGGATTAA 721 CCAGAGAGCT CCCTGCTGAG GAAAAAATCT CCCAGATGCT GAAAGTGAGG CCATGTGGCT 781 TGGCCAAATA AAACCTGGCT CCGTGGTGCC TCTGTCTTAG CAGCCACCCT GCTGATGAAC 841 TGCCACCTTG GACTTGGGAC CAGAAAGAGG TGGGTTGGGT GAAGAGGCAC CACACAGAGT 901 GATGTAACAG CAAGATCAGG TCACCCACAG GCCCTGGCAG TCACAGTCAT AAATTAGCTA 961 ACTGTACACA AGCTGGGGAC ACTCCCTTTG GAAACCAAAA AAAAAAAAA AAAAAAGAGA 1021 CCTTTATGCA AAAACAACTC TCTGGATGGC ATGGGGTGAG TATAAATACT TCTTGGCTGC 1081 CAGTGTGTTC ATAACTTTGT AGCGAGTCGA AAACTGAGGC TCCGGCCGCA GAGAACTCAG 1141 CCTCATTCCT GCTTTAAAAT CTCTCGGCCA CCTTTGATGA GGGGACTGGG CAGTTCTAGA 1201 CAGTCCCGAA GTTCTCAAGG CACAGGTCTC TTCCTGGTTT GACTGTCCTT ACCCCGGGGA 1261 GGCAGTGCAG CCAGCTGCAA GGTGAGTTGC C (2) INFORMATION FOR SEQ ID NO:2507: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2507: 1 CTGCTTTAAA ATCTCTCGGC CACCTTTGAT GAGGGGACTG GGCAGTTCTA GACAGTCCCG 61 AAGTTCTCAA GGCACAGGTC TCTTCCTGGT TTGACTGTCC TTACCCCGGG GAGGCAGTGC 12i AGCCAGCTGC AAGCCCCACA GTGAAGAACA TCTGAGCTCA AATCCAGATA AGTGACATAA 181 GTGACCTGCT TTGTAAAGCC ATAGAGATGG CCTGTCCTTG GAAATTTCTG TTCAAGACCA 241 AATTCCACCA GTATGCAATG AATGGGGAAA AAGACATCAA CAACAATGTG GAGAAAGCCC 301 CCTGTGCCAC CTCCAGTCCA GTGACACAGG ATGACCTTCA GTATCACAAC CTCAGCAAGC 361 AGCAGAATGA GTCCCCGCAG CCCCTCGTGG AGACGGGAAA GAAGTCTCCA GAATCTCTGG 421 TCAAGCTGGA TGCAACCCCA TTGTCCTCCC CACGGCATGT GAGGATCAAA AACTGGGGCA 481 GCGGGATGAC TTTCCAAGAC ACACTTCACC ATAAGGCCAA AGGGATTTTA ACTTGCAGGT 541 CCAAATCTTG CCTGGGGTCC ATTATGACTC CCAAAAGTTT GACCAGAGGA CCCAGGGACA WO 00/09525 PCT/US99/17712 EPI-109 665 601 AGCCTACCCC TCCAGATGAG CTTCTACCTC AAGCTATCGA ATTTGTCAAC CAATATTACG 661 GCTCCTTCAA AGAGGCAAAA ATAGAGGAAC ATCTGGCCAG GGTGGAAGCG GTAACAAAGG 721 AGATAGAAAC AACAGGAACC TACCAACTGA CGGGAGATGA GCTCATCTTC GCCACCAAGC 781 AGGCCTGGCG CAATGCCCCA CGCTGCATTG GGAGGATCCA GTGGTCCAAC CTGCAGGTCT 841 TCGATGCCCG CAGCTGTTCC ACTGCCCGGG AAATGTTTGA ACACATCTGC AGACACGTGC 901 GTTACTCCAC CAACAATGGC AACATCAGGT CGGCCATCAC CGTGTTCCCC CAGCGGAGTG 961 ATGGCAAGCA CGACTTCCGG GTGTGGAATG CTCAGCTCAT CCGCTATGCT GGCTACCAGA 1021 TGCCAGATGG CAGCATCAGA GGGGACCCTG CCAACGTGGA ATTCACTCAG CTGTGCATCG 1081 ACCTGGGCTG GAAGCCCAAG TACGGCCGCT TCGATGTGGT CCCCCTGGTC CTGCAGGCCA 1141 ATGGCCGTGA CCCTGAGCTC TTCGAAATCC CACCTGACCT TGTGCTTGAG GTGGCCATGG 1201 AACATCCCAA ATACGAGTGG TTTCGGGAAC TGGAGCTAAA GTGGTACGCC CTGCCTGCAG 1261 TGGCCAACAT GCTGCTTGAG GTGGGCGGCC TGGAGTTCCC AGGGTGCCCC TTCAATGGCT 1321 GGTACATGGG CACAGAGATC GGAGTCCGGG ACTTCTGTGA CGTCCAGCGC TACAACATCC 1381 TGGAGGAAGT GGGCAGGAGA ATGGGCCTGG AAACGCACAA GCTGGCCTCG CTCTGGAAAG 1441 ACCAGGCTGT CGTTGAGATC AACATTGCTG TGATCCATAG TTTTCAGAAG CAGAATGTGA 1501 CCATCATGGA CCACCACTCG GCTGCAGAAT CCTTCATGAA GTACATGCAG AATGAATACC 1561 GGTCCCGTGG GGGCTGCCCG GCAGACTGGA TTTGGCTGGT CCCTCCCATG TCTGGGAGCA 1621 TCACCCCCGT GTTTCACCAG GAGATGCTGA ACTACGTCCT GTCCCCTTTC TACTACTATC 1681 AGGTAGAGGC CTGGAAAACC CATGTCTGGC AGGACGAGAA GCGGAGACCC AAGAGAAGAG 1741 AGATTCCATT GAAAGTCTTG GTCAAAGCTG TGCTCTTTGC CTGTATGCTG ATGCGCAAGA 1801 CAATGGCGTC CCGAGTCAGA GTCACCATCC TCTTTGCGAC AGAGACAGGA AAATCAGAGG 1861 CGCTGGCCTG GGACCTGGGG GCCTTATTCA GCTGTGCCTT CAACCCCAAG GTTGTCTGCA 1921 TGGATAAGTA CAGGCTGAGC TGCCTGGAGG AGGAACGGCT GCTGTTGGTG GTGACCAGTA 1981 CGTTTGGCAA TGGAGACTGC CCTGGCAATG GAGAGAAACT GAAGAAATCG CTCTTCATGC 2041 TGAAAGAGCT CAACAACAAA TTCAGGTACG CTGTGTTTGG CCTCGGCTCC AGCATGTACC 2101 CTCGGTTCTG CGCCTTTGCT CATGACATTG ATCAGAAGCT GTCCCACCTG GGGGCCTCTC 2161 AGCTCACCCC GATGGGAGAA GGGGATGAGC TCAGTGGGCA GGAGGACGCC TTCCGCAGCT 2221 GGGCCGTGCA AACCTTCAAG GCAGCCTGTG AGACGTTTGA TGTCCGAGGC AAACAGCACA 2281 TTCAGATCCC CAAGCTCTAC ACCTCCAATG TGACCTGGGA CCCGCACCAC TACAGGCTCG 2341 TGCAGGACTC ACAGCCTTTG GACCTCAGCA AAGCCCTCAG CAGCATGCAT GCCAAGAACG 2401 TGTTCACCAT GAGGCTCAAA TCTCGGCAGA ATCTACAAAG TCCGACATCC AGCCGTGCCA 2461 CCATCCTGGT GGAACTCTCC TGTGAGGATG GCCAAGGCCT GAACTACCTG CCGGGGGAGC 2521 ACCTTGGGGT TTGCCCAGGC AACCAGCCGG CCCTGGTCCA AGGCATCCTG GAGCGAGTGG 2581 TGGATGGCCC CACACCCCAC CAGACAGTGC GCCTGGAGGA CCTGGATGAG AGTGGCAGCT 2641 ACTGGGTCAG TGACAAGAGG CTGCCCCCCT GCTCACTCAG CCAGGCCCTC ACCTACTCCC 2701 CGGACATCAC CACACCCCCA ACCCAGCTGC TGCTCCAAAA GCTGGCCCAG GTGGCCACAG 2761 AAGAGCCTGA GAGACAGAGG CTGGAGGCCC TGTGCCAGCC CTCAGAGTAC AGCAAGTGGA 2821 AGTTCACCAA CAGCCCCACA TTCCTGGAGG TGCTAGAGGA GTTCCCGTCC CTGCGGGTGT 2881 CTGCTGGCTT CCTGCTTTCC CAGCTCCCCA TTCTGAAGCC CAGGTTCTAC TCCATCAGCT 2941 CCTCCCGGGA TCACACGCCC ACGGAGATCC ACCTGACTGT GGCCGTGGTC ACCTACCACA 3001 CCGGAGATGG CCAGGGTCCC CTGCACCACG GTGTCTGCAG CACATGGCTC AACAGCCTGA 3061 AGCCCCAAGA CCCAGTGCCC TGCTTTGTGC GGAATGCCAG CGCCTTCCAC CTCCCCGAGG 3121 ATCCCTCCCA TCCTTGCATC CTCATCGGGC CTGGCACAGG CATCGTGCCC TTCCGCAGTT 3181 TCTGGCAGCA ACGGCTCCAT GACTCCCAGC ACAAGGGAGT GCGGGGAGGC CGCATGACCT 3241 TGGTGTTTGG GTGCCGCCGC CCAGATGAGG ACCACATCTA CCAGGAGGAG ATGCTGGAGA 3301 TGGCCCAGAA GGGGGTGCTG CATGCGGTGC ACACAGCCTA TTCCCGCCTG CCTGGCAAGC 3361 CCAAGGTCTA TGTTCAGGAC ATCCTGCGGC AGCAGCTGGC CAGCGAGGTG CTCCGTGTGC 3421 TCCACAAGGA GCCAGGCCAC CTCTATGTTT GCGGGGATGT GCGCATGGCC CGGGACGTGG 3481 CCCACACCCT GAAGCAGCT G GTGGCTGCCA AGCTGAAATT GAATGAGGAG CAGGTCGAGG 3541 ACTATTTCTT TCAGCTCAAG AGCCAGAAGC GCTATCACGA AGATATCTTC GGTGCTGTAT 3601 TTCCTTACGA. GGCGAAGAAG GACAGGGTGG CGGTGCAGCC CAGCAGCCTG GAGATGTCAG 3661 CGCTCTGAGG GCCTACAGGA GGGGTTAAAG CTGCCGGCAC AGAACTTAAG GATGGAGCCA 3721 GCTCTGCATT ATCTGAGGTC ACAGGGCCTG GGGAGATGGA GGAAAGTGAT ATCCCCCAGC 3781 CTCAAGTCTT ATTTCCTCAA CGTTGCTCCC CATCAAGCCC TTTACTTGAC CTCCTAACAA 3841 GTAGCACCCT GGATTGATCG GAGCCTCCTC TCTCAAACTG GGGCCTCCCT GGTCCCTTGG 3901 AGACAAAATC TTAAATGCCA GGCCTGGCGA GTGGGTGAAA GATGGAACTT GCTGCTGAGT 3961 GCACCACTTC AAGTGACCAC CAGGAGGTGC TATCGCACCA CTGTGTATTT AACTGCCTTG 4021 TGTACAGTTA TTTATGCCTC TGTATTTAAA AAACTAACAC CCAGTCTGTT CCCCATGGCC 4081 ACTTGGGTCT TCCCTGTATG ATTCCTTGAT GGAGATATTT ACATGAATTG CATTTTACTT 4141,TTAATC (2) INFORMATION FOR SEQ ID NO:2508: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 4077 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D3 TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2508: 1 GAATTCCCAC TCTGCTGCCT GCTCCAGCAG ACGGACGCAC AGTAACATGG GCAACTTGAA WO 00/09525 PCT/US99/17712 EPI-109 666 61 GAGCGTGGCC CAGGAGCCTG GGCCACCCTG CGGCCTGGGG CTGGGGCTGG GCCTTGGGCT 121 GTGCGGCAAG CAGGGCCCAG CCACCCCGGC CCCTGAGCCC AGCCGGGCCC CAGCATCCCT 181 ACTCCCACCA GCGCCAGAAC ACAGCCCCCC GAGCTCCCCG CTAACCCAGC CCCCAGAGGG 241 GCCCAAGTTC CCTCGTGTGA AGAACTGGGA GGTGGGGAGC ATCACCTATG ACACCCTCAG 301 CGCCCAGGCG CAGCAGGATG GGCCCTGCAC CCCAAGACGC TGCCTGGGCT CCCTGGTATT 361 TCCACGGAAA CTACAGGGCC GGCCCTCCCC CGGCCCCCCG GCCCCTGAGC AGCTGCTGAG 421 TCAGGCCCGG GACTTCATCA ACCAGTACTA CAGCTCCATT AAGAGGAGCG GCTCCCAGGC 481 CCACGAACAG CGGCTTCAAG AGGTGGAAGC CGAGGTGGCA GCCACAGGCA CCTACCAGCT 541 TAGGGAGAGC GAGCTGGTGT TCGGGGCTAA GCAGGCCTGG CGCAACGCTC CCCGCTGCGT 601 GGGCCGGATC CAGTGGGGGA AGCTGCAGGT GTTCGATGCC CGGGACTGCA GGTCTGCACA 661 GGAAATGTTC ACCTACATCT GCAACCACAT CAAGTATGCC ACCAACCGGG GCAACCTTCG 721 CTCGGCCATC ACAGTGTTCC CGCAGCGCTG CCCTGGCCGA GGAGACTTCC GAATCTGGAA 781 CAGCCAGCTG GTGCGCTACG CGGGCTACCG GCAGCAGGAC GGCTCTGTGC GGGGGGACCC 841 AGCCAACGTG GAGATCACCG AGCTCTGCAT TCAGCACGGC TGGACCCCAG GAAACGGTCG 901 CTTCGACGTG CTGCCCCTGC TGCTGCAGGC CCCAGATGAG CCCCCAGAAC TCTTCCTTCT 961 GCCCCCCGAG CTGGTCCTTG AGGTGCCCCT GGAGCACCCC ACGCTGGAGT GGTTTGCAGC 1021 CCTGGGCCTG CGCTGGTACG CCCTCCCGGC AGTGTCCAAC ATGCTGCTGG AAATTGGGGG 1081 CCTGGAGTTC CCCGCAGCCC CCTTCAGTGG CTGGTACATG AGCACTGAGA TCGGCACGAG 1141 GAACCTGTGT GACCCTCACC GCTACAACAT CCTGGAGGAT GTGGCTGTCT GCATGGACCT 1201 GGATACCCGG ACCACCTCGT CCCTGTGGAA AGACAAGGCA GCAGTGGAAA TCAACGTGGC 1261 CGTGCTGCAC AGTTACCAGC TAGCCAAAGT CACCATCGTG GACCACCACG CCGCCACGGC 1321 CTCTTTCATG AAGCACCTGG AGAATGAGCA GAAGGCCAGG GGGGGCTGCC CTGCAGACTG 1381 GGCCTGGATC GTGCCCCCCA TCTCGGGCAG CCTCACTCCT GTTTTCCATC AGGAGATGGT 1441 CAACTATTTC CTGTCCCCGG CCTTCCGCTA CCAGCCAGAC CCCTGGAAGG GGAGTGCCGC 1501 CAAGGGCACC GGCATCACCA GGAAGAAGAC CTTTAAAGAA GTGGCCAACG CCGTGAAGAT 1561 CTCCGCCTCG CTCATGGGCA CGGTGATGGC GAAGCGAGTG AAGGCGACAA TCCTGTATGG 1621 CTCCGAGACC GGCCGGGCCC AGAGCTACGC ACAGCAGCTG GGGAGACTCT TCCGGAAGGC 1681 TTTTGATCCC CGGGTCCTGT GTATGGATGA GTATGACGTG GTGTCCCTCG AACACGAGAC 1741 GCTGGTGCTG GTGGTAACCA GCACATTTGG GAATGGGGAT CCCCCGGAGA ATGGAGAGAG 1801 CTTTGCAGCT GCCCTGATGG AGATGTCCGG CCCCTACAAC AGCTCCCCTC GGCCGGAACA 1861 GCACAAGAGT TATAAGATCt GCTTCAACAG CATCTCCTGC TCAGACCCAC TGGTGTCCTC 1921 TTGGCGGCGG AAGAGGAAGG AGTCCAGTAA CACAGACAGT CAGGGGCCC TGGGCACCCT 1981 CAGGTTCTGT GTGTTCGGGC TCGGCTCCCG GGCATACCCC CACTTCTGCG CCTTTGCTCG 2041 TGCCGTGGAC ACACGGCTGG AGGAACTGGG CGGGGAGCGG CTGCTGCAGC TGGGCCAGGG 2101 CGACGAGCTG TGCGGCCAGG AGGAGGCCTT CCGAGGCTGG GCCCAGGCTG CCTTCCAGGC 2161 CGCCTGTGAG ACCTTCTGTG TGGGAGAGGA TGCCAAGGCC GCCGCCCGAG ACATCTTCAG 2221 CCCCAAACGG AGCTGGAAGC GCCAGAGGTA CCGGCTGAGC GCCCAGGCCG AGGGCCTGCA 2281 GTTGCTGCCA GGTCTGATCC ACGTGCACAG GCGGAAGATG TTCCAGGCTA CAATCCGCTC 2341 AGTGGAAAAC CTGCAAAGCA GCAAGTCCAC GAGGGCCACC ATCCTGGTGC GCCTGGACAC 2401 CGGAGGCCAG GAGGGGCTGC AGTACCAGCC GGGGGACCAC ATAGGTGTCT GCCCGCCCAA 2461 CCGGCCCGGC CTTGTGGAGG CGCTGCTGAG CCGCGTGGAG GACCCGCCGG CGCCCACTGA 2521 GCCCGTGGCA GTAGAGCAGC TGGAGAAGGG CAGCCCTGGT GGCCCTCCCC CCGGCTGGGT 2581 GCGGGACCCC CGGCTGCCCC CGTGCACGCT GCGCCAGGCT CTCACCTTCT TCCTGGACAT 2641 CACCTCCCCA CCCAGCCCTC AGCTCTTGCG GCTGCTCAGC ACCTTGGCAG AAGAGCCCAG 2701 GGAACAGCAG GAGCTGGAGG CCCTCAGCCA GGATCCCCGA CGCTACGAGG AGTGGAAGTG 2761 GTTCCGCTGC CCCACGCTGC TGGAGGTGCT GGAGCAGTTC CCGTCGGTGG CGCTGCCTGC 2821 CCCACTGCTC CTCACCCAGC TGCCTCTGCT CCAGCCCCGG TACTACTCAG TCAGCTCGGC 2881 ACCCAGCACC CACCCAGGAG AGATCCACCT CACTGTAGCT GTGCTGGCAT ACAGGACTCA 2941 GGATGGGCTG GGCCCCCTGC ACTATGGAGT CTGCTCCACG TGGCTAAGCC AGCTCAAGCC 3001 CGGAGACCCT GTGCCCTGCT TCATCCGGGG GGCTCCCTCC TTCCGGCTCC CACCCGATCC 3061 CAGCTTGCCC TGCATCCTGG TGGGTCCAGG CACTGGCATT GCCCCCTTCC GGGGATTCTG 3121 GCAGGAGCGG CTGCATGACA TTGAGAGCAA ACCGCTGCAG CCCACTCCCA TGACTTTGGT 3181 GTTCGGCTGC CGATGCTCCC AACTTGACCA TCTCTACCGC GACGAGGTGC AGAACGCCCA 3241 GCAGCGCGGG GTGTTTGGCC GAGTCCTCAC CGCCTTCTCC CGGGAACCTG ACAACCCCAA 3301 GACCTACGTG CAGGACATCC TGAGGACGGA GCTGGCTGCG CAGGTGCACC GCGTGCTGTG 3361 CCTCGAGCGG GGCCACATGT TTGTCTGCGG CGATGTTACC ATGGCAACCA ACGTCCTGCA 3421 GACCGTGCAG CGCATCCTGG CGACGGAGGG CGACATGGAG CTGGACGAGG CCGGCGACGT 3481 CATCGGCGTG CTGCGGGATC AGCAACGCTA CCACGAAGAC ATTTTCGGGC TCACGCTCCG 3541 CACCCAGGAG GTGACAAGCC GCATACGCAC CCAGAGCTTT TCCTTGCAGG AGCGTCAGTT 3601 GCGGGGCGCA GTGCCCTGGG CGTTCGACCC TCCCGGCTCA GACACCAACA GCCCCTGAGA 3661 GCCGCCTGGC TTTCCCTTCC AGTTCCGGGA GAGCGGCTGC CCGACTCACC TCCGCCCGAC 3721 CAGGATCAGC CCCGCTCCTC CCCTCTTGAG GTGGTGCCTT CTCACATCTG TCCAGAGGCT 3781 GCAAGGATTC AGCATTATTC CTCCAGGAAG GAGCAAAACG CCTCTTTTCC CTCTCTAGC 3841 CTGTTGCCTC GGGCCTGGGT CCGCCTTAAT CTGGAAGGCC CCTCCCAGCA GCGGTACCCC 3901 AGGGCCTACT GCCACCCGCT TCCTGTTTCT TAGTCCGAAT GTTAGATTCC TCTTGCCTCT 3961 CTCAGGAGTA TCTTACCTGT AAAGTCTAAT CTCTAAATCA AGTATTTATT ATTGAAGATT 4021 TACCATAAGG GACTGTGCCA GATGTTAGGA GAACTACTAA AGTGCCTACC CCAGCTC WO 00/09525 PCT/US99/17712 EPI-109 667 (2) INFORMATION FOR SEQ ID NO:2509: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 2- base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2509: 1 CATATGTATG GGAATACTGT ATTTCAGGCA TTATAAGGAA TGAAATTATA GGCCGGGCAT 61 TGTGGCTAAC CCTTGTAATC CTAGCACTTT GAGAGGCTGA AGTGGGCAGA TCACTTGAGC 121 TTCAGAGTTC GAGACCAGCA TGGACAACAT GGTGAAACCC AGTCTCTACC AAAAACACAA 181 AAATATTAGC TGGGTGTGGT GGTGCATGCC TGTAGTCCCA GCTACTCAGG AGGCTGAGGT 241 GGGAGGATCG CTTGAGCCTG GGAGGCAGAA GTTGCAATGA GCAGAGATCG TGCCACTCCG 301 CTCCAGTCTT GGTGACAGAA TGAGACTCCA TCTCAAAAAT AAATAAATAA ATAAATAAAA 361 TAAATGAAAT GAAATTATAA GAAATTACCA CTTTTTCATG TAAGAAGTGA TCATTTCCAT 421 TATAAGGGAA GGAATTTAAT CCTACCTGCC ATTCCACCAA AGCTTACCTA GTGCTAAAGG 481 ATGAGGTGTT AGTAAGACCA ACATCTCAGA GGCCTCTCTG TGCCAATAGC CTTCCTTCCT 541 TTCCCTTCCA AAAACCTCAA GTGACTAGTT CAGAGGCCTG TCTGGAATAA TGGCATCATC 601 TAATATCACT GGCCTTCTGG AACCTGGGCA TTTTCCAGTG TGTTCCATAC TGTCAATATT 661 CCCCCAGCTT CCTGGACTCC TGTCACAAGC TGGAAAAGTG AGAGGATGGA CAGGGATTAA 721 CCAGAGAGCT CCCTGCTGAG GAAAAAATCT CCCAGATGCT GAAAGTGAGG CCATGTGGCT 781 TGGCCAAATA AAACCTGGCT CCGTGGTGCC TCTGTCTTAG CAGCCACCCT GCTGATGAAC 841 TGCCACCTTG GACTTGGGAC CAGAAAGAGG TGGGTTGGGT GAAGAGGCAC CACACAGAGT 901 GATGTAACAG CAAGATCAGG TCACCCACAG GCCCTGGCAG TCACAGTCAT AAATTAGCTA 961 ACTGTACACA AGCTGGGGAC ACTCCCTTTG GAAACCAAAA AAAAAAAAAA AAAAAAGAGA 1021 CCTTTATGCA AAAACAACTC TCTGGATGGC ATGGGGTGAG TATAAATACT TCTTGGCTGC 1081 CAGTGTGTTC ATAACTTTGT AGCGAGTCGA AAACTGAGGC TCCGGCCGCA GAGAACTCAG 1141 CCTCATTCCT GCTTTAAAAT CTCTCGGCCA CCTTTGATGA GGGGACTGGG CAGTTCTAGA 1201 CAGTCCCGAA GTTCTCAAGG CACAGGTCTC TTCCTGGTTT GACTGTCCTT ACCCCGGGGA 1261 GGCAGTGCAG CCAGCTGCAA GGTGAGTTGC C 1 CTGCTTTAAA ATCTCTCGGC CACCTTTGAT GAGGGGACTG GGCAGTTCTA GACAGTCCCG 61 AAGTTCTCAA GGCACAGGTC TCTTCCTGGT TTGACTGTCC TTACCCCGGG GAGGCAGTGC 121 AGCCAGCTGC AAGCCCCACA GTGAAGAACA TCTGAGCTCA AATCCAGATA AGTGACATAA 181 GTGACCTGCT TTGTAAAGCC ATAGAGATGG CCTGTCCTTG GAAATTTCTG TTCAAGACCA 241 AATTCCACCA GTATGCAATG AATGGGGAAA AAGACATCAA CAACAATGTG GAGAAAGCCC 301 CCTGTGCCAC CTCCAGTCCA GTGACACAGG ATGACCTTCA GTATCACAAC CTCAGCAAGC 361 AGCAGAATGA GTCCCCGCAG CCCCTCGTGG AGACGGGAAA GAAGTCTCCA GAATCTCTGG 421 TCAAGCTGGA TGCAACCCCA TTGTCCTCCC CACGGCATGT GAGGATCAAA AACTGGGGCA 481 GCGGGATGAC TTTCCAAGAC ACACTTCACC ATAAGGCCAA AGGGATTTTA ACTTGCAGGT 541 CCAAATCTTG CCTGGGGTCC ATTATGACTC CCAAAAGTTT GACCAGAGGA CCCAGGGACA 601 AGCCTACCCC TCCAGATGAG CTTCTACCTC AAGCTATCGA ATTTGTCAAC CAATATTACG 661 GCTCCTTCAA AGAGGCAAAA ATAGAGGAAC ATCTGGCCAG GGTGGAAGCG GTAACAAAGG 721 AGATAGAAAC AACAGGAACC TACCAACTGA CGGGAGATGA GCTCATCTTC GCCACCAAGC 781 AGGCCTGGCG CAATGCCCCA CGCTGCATTG GGAGGATCCA GTGGTCCAAC CTGCAGGTCT 841 TCGATGCCCG CAGCTGTTCC ACTGCCCGGG AAATGTTTGA ACACATCTGC AGACACGTGC 901 GTTACTCCAC CAACAATGGC AACATCAGGT CGGCCATCAC CGTGTTCCCC CAGCGGAGTG 961 ATGGCAAGCA CGACTTCCGG GTGTGGAATG CTCAGCTCAT CCGCTATGCT GGCTACCAGA 1021 TGCCAGATGG CAGCATCAGA GGGGACCCTG CCAACGTGGA ATTCACTCAG CTGTGCATCG 1081 ACCTGGGCTG GAAGCCCAAG TACGGCCGCT TCGATGTGGT CCCCCTGGTC CTGCAGGCCA 1141 ATGGCCGTGA CCCTGAGCTC TTCGAAATCC CACCTGACCT TGTGCTTGAG GTGGCCATGG 1201 AACATCCCAA ATACGAGTGG TTTCGGGAAC TGGAGCTAAA GTGGTACGCC CTGCCTGCAG 1261 TGGCCAACAT GCTGCTTGAG GTGGGCGGCC TGGAGTTCCC AGGGTGCCCC TTCAATGGCT 1321 GGTACATGGG CACAGAGATC GGAGTCCGGG ACTTCTGTGA CGTCCAGCGC TACAACATCC 1381 TGGAGGAAGT GGGCAGGAGA ATGGGCCTGG AAACGCACAA GCTGGCCTCG CTCTGGAAAG 1441 ACCAGGCTGT CGTTGAGATC AACATTGCTG TGATCCATAG TTTTCAGAAG CAGAATGTGA 1501 CCATCATGGA CCACCACTCG GCTGCAGAAT CCTTCATGAA GTACATGCAG AATGAATACC 1561 GGTCCCGTGG GGGCTGCCCG GCAGACTGGA TTTGGCTGGT CCCTCCCATG TCTGGGAGCA 1621 TCACCCCCGT GTTTCACCAG GAGATGCTGA ACTACGTCCT GTCCCCTTTC TACTACTATC 1681 AGGTAGAGGC CTGGAAAACC CATGTCTGGC AGGACGAGAA GCGGAGACCC AAGAGAAGAG 1741 AGATTCCATT GAAAGTCTTG GTCAAAGCTG TGCTCTTTGC CTGTATGCTG ATGCGCAAGA 1801 CAATGGCGTC CCGAGTCAGA GTCACCATCC TCTTTGCGAC AGAGACAGGA AAATCAGAGG 1861 CGCTGGCCTG GGACCTGGGG GCCTTATTCA GCTGTGCCTT CAACCCCAAG GTTGTCTGCA 1921 TGGATAAGTA CAGGCTGAGC TGCCTGGAGG AGGAACGGCT GCTGTTGGTG GTGACCAGTA 1981 CGTTTGGCAA TGGAGACTGC CCTGGCAATG GAGAGAAACT GAAGAAATCG CTCTTCATGC 2041 TGAAAGAGCT CAACAACAAA TTCAGGTACG CTGTGTTTGG CCTCGGCTCC AGCATGTACC 2101 CTCGGTTCTG CGCCTTTGCT CATGACATTG ATCAGAAGCT GTCCCACCTG GGGGCCTCTC 2161 AGCTCACCCC GATGGGAGAA GGGGATGAGC TCAGTGGGCA GGAGGACGCC TTCCGCAGCT 2221 GGGCCGTGCA AACCTTCAAG GCAGCCTGTG AGACGTTTGA TGTCCGAGGC AAACAGCACA 2281 TTCAGATCCC CAAGCTCTAC ACCTCCAATG TGACCTGGGA CCCGCACCAC TACAGGCTCG 2341 TGCAGGACTC ACAGCCTTTG GACCTCAGCA AAGCCCTCAG CAGCATGCAT GCCAAGAACG WO 00/09525 PCT/US99/17712 EPI-109 668 2401 TGTTCACCAT GAGGCTCAAA TCTCGGCAGA ATCTACAAAG TCCGACATCC AGCCGTGCCA 2461 CCATCCTGGT GGAACTCTCC TGTGAGGATG GCCAAGGCCT GAACTACCTG CCGGGGGAGC 2521 ACCTTGGGGT TTGCCCAGGC AACCAGCCGG CCCTGGTCCA AGGCATCCTG GAGCGAGTGG 2581 TGGATGGCCC CACACCCCAC CAGACAGTCC GCCTGGAGGA CCTGGATGAG AGTGGCAGCT 2641 ACTGGGTCAG TGACAAGAGG CTGCCCCCCT GCTCACTCAG CCAGGCCCTC ACCTACTCCC 2701 CGGACATCAC CACACCCCCA ACCCAGCTGC TGCTCCAAAA GCTGGCCCAG GTGGCCACAG 2761 AAGAGCCTGA GAGACAGAGG CTGGAGGCCC TGTGCCAGCC CTCAGAGTAC AGCAAGTGGA 2821 AGTTCACCAA CAGCCCCACA TTCCTGGAGG TGCTAGAGGA GTTCCCGTCC CTGCGGGTGT 2881 CTGCTGGCTT CCTGCTTTCC CAGCTCCCCA TTCTGAAGCC CAGGTTCTAC TCCATCAGCT 2941 CCTCCCGGGA TCACACGCCC ACGGAGATCC ACCTGACTGT GGCCGTGGTC ACCTACCACA 3001 CCGGAGATGG CCAGGGTCCC CTGCACCACG GTGTCTGCAG CACATGGCTC AACAGCCTGA 3061 AGCCCCAAGA CCCAGTGCCC TGCTTTGTGC GGAATGCCAG CGCCTTCCAC CTCCCCGAGG 3121 ATCCCTCCCA TCCTTGCATC CTCATCGGGC CTGGCACAGG CATCGTGCCC TTCCGCAGTT 3181 TCTGGCAGCA ACGGCTCCAT GACTCCCAGC ACAAGGGAGT GCGGGGAGGC CGCATGACCT 3241 TGGTGTTTGG GTGCCGCCGC CCAGATGAGG ACCACATCTA CCAGGAGGAG ATGCTGGAGA 3301 TGGCCCAGAA GGGGGTGCTG CATGCGGTGC ACACAGCCTA TTCCCGCCTG CCTGGCAAGC 3361 CCAAGGTCTA TGTTCAGGAC ATCCTGCGCC AGCAGCTGGC CAGCGAGGTG CTCCGTGTC 3421 TCCACAAGGA GCCAGGCCAC CTCTATGTTT GCGGGGATGT GCGCATGGCC CGGGACGTGG 3481 CCCACACCCT GAAGCAGCTG GTGGCTGCCA AGCTGAAATT GAATGAGGAG CAGGTCGAGG 3541 ACTATTTCTT TCAGCTCAAG AGCCAGAAGC GCTATCACGA AGATATCTTC GGTGCTGTAT 3601 TTCCTTACGA GGCGAAGAAG GACAGGGTGG CGGTGCAGCC CAGCAGCCTG GAGATGTCAG 3661 CGCTCTGAGG GCCTACAGGA GGGGTTAAAG CTGCCGGCAC AGAACTTAAG GATGGAGCCA 3721 GCTCTGCATT ATCTGAGGTC ACAGGGCCTG GGGAGATGGA GGAAAGTGAT ATCCCCCAGC 3781 CTCAAGTCTT ATTTCCTCAA CGTTGCTCCC CATCAAGCCC TTTACTTGAC CTCCTAACAA 3841 GTAGCACCCT GGATTGATCG GAGCCTCCTC TCTCAAACTG GGGCCTCCCT GGTCCCTTGG 3901 AGACAAAATC TTAAATGCCA GGCCTGGCGA GTGGGTGAAA GATGGAACTT GCTGCTGAGT 3961 GCACCACTTC AAGTGACCAC CAGGAGGTGC TATCGCACCA CTGTGTATTT AACTGCCTTG 4021 TGTACAGTTA TTTATGCCTC TGTATTTAAA AAACTAACAC CCAGTCTGTT CCCCATGGCC 4081 ACTTGGGTCT TCCCTGTATG ATTCCTTGAT GGAGATATTT ACATGAATTG CATTTTACTT 4141 TAATC 1 GAATTCCCAC TCTGCTGCCT GCTCCAGCAG ACGGACGCAC AGTAACATGG GCAACTTGAA 61 GAGCGTGGCC CAGGAGCCTG GGCCACCCTG CGGCCTGGGG CTGGGGCTGG GCCTTGGGCT 121 GTGCGGCAAG CAGGGCCCAG CCACCCCGGC CCCTGAGCCC AGCCGGGCCC CAGCATCCCT 181 ACTCCCACCA GCGCCAGAAC ACAGCCCCCC GAGCTCCCCG CTAACCCAGC CCCCAGAGGG 241 GCCCAAGTTC CCTCGTGTGA AGAACTGGGA GGTGGGGAGC ATCACCTATG ACACCCTCAG 301 CGCCCAGGCG CAGCAGGATG GGCCCTGCAC CCCAAGACCC TGCCTGGGCT CCCTGGTATT 361 TCCACGGAAA CTACAGGGCC GGCCCTCCCC CGGCCCCCCG GCCCCTGAGC AGCTGCTGAG 421 TCAGGCCCGG GACTTCATCA ACCAGTACTA CAGCTCCATT AAGAGGAGCG GCTCCCAGGC 481 CCACGAACAG CGGCTTCAAG AGGTGGAAGC CGAGGTGGCA GCCACAGGCA CCTACCAGCT 541 TAGGGAGAGC GAGCTGGTGT TCGGGGCTAA GCAGGCCTCG CGCAACGCTC CCCGCTGCGT 601 GGGCCGGATC CAGTGGGGGA AGCTGCAGGT GTTCGATGCC CGGGACTGCA GGTCTGCACA 661 GGAAATGTTC ACCTACATCT GCAACCACAT CAAGTATGCC ACCAACCCGG GCAACCTTCG 721 CTCGGCCATC ACAGTGTTCC CGCAGCGCTG CCCTGGCCGA GGAGACTTCC GAATCTGGAA 781 CAGCCAGCTG GTGCGCTACG CGGGCTACCG GCAGCAGGAC GGCTCTGTGC GGGGGGACCC 841 AGCCAACGTG GAGATCACCG AGCTCTGCAT TCAGCACGGC TGGACCCCAG GAAACGGTCG 901 CTTCGACGTG CTGCCCC'rGC TGCTGCAGGC CCCAGATGAG CCCCCAGAAC TCTTCCTTCT 961 GCCCCCCGAG CTGGTCCTTG AGGTGCCCCT GGAGCACCCC ACGCTGGAGT GGTTTGCAGC 1021 CCTGGGCCTG CGCTGGTACG CCCTCCCGGC AGTGTCCAAC ATGCTGCTGG AAATTGGGGG 1081 CCTGGAGTTC CCCGCAGCCC CCTTCAGTGG CTGGTACATG AGCACTGAGA TCGGCACGAG 1141 GAACCTGTGT GACCCTCACC GCTACAACAT CCTGGAGGAT GTGGCTGTCT GCATGGACCT 1201 GGATACCCGG ACCACCTCGT CCCTGTGGAA AGACAAGGCA GCAGTGGAAA TCAACGTGGC 1261 CGTGCTGCAC AGTTACCAGC TAGCCAAAGT CACCATCGTG GACCACCACG CCGCCACGGC 1321 CTCTTTCATG AAGCACCTGG AGAATGAGCA GAAGGCCAGG GGGGGCTGCC CTGCAGACTG 1381 GGCCTGGATC GTGCCCCCCA TCTCGGGCAG CCTCACTCCT GTTTTCCATC AGGAGATGGT 1441 CAACTATTTC CTGTCCCCGG CCTTCCGCTA CCAGCCAGAC CCCTGGAAGG GGAGTGCCGC 1501 CAAGGGCACC GGCATCACCA GGAAGAAGAC CTTTAAAGAA GTGGCCAACG CCGTGAAGAT 1561 CTCCGCCTCG CTCATGGGCA CGGTGATGGC GAAGCGACTG AAGGCGACAA TCCTGTATGG 1621 CTCCGAGACC GGCCGGGCCC AGAGCTACGC ACAGCAGCTG GGGAGACTCT TCCGGAAGGC 1681 TTTTGATCCC CGGGTCCTGT GTATGGATGA GTATGACGTG GTGTCCCTCG AACACGAGAC 1741 GCTGGTGCTG GTGGTAACCA GCACATTTGG GAATGGGGAT CCCCCGGAGA ATGGAGAGAG 1801 CTTTGCAGCT GCCCTGATGG AGATGTCCGG CCCCTACAAC AGCTCCCCTC GGCCGGAACA 1861 GCACAAGAGT TATAAGATCC GCTTCAACAG CATCTCCTGC TCAGACCCAC TGGTGTCCTC 1921 TTGGCGGCGG AAGAGGAAGG AGTCCAGTAA CACAGACACT GCAGGGGCCC TGGGCACCCT 1981 CAGGTTCTGT GTGTTCGGGC TCGGCTCCCG GGCATACCCC CACTTCTGCG CCTTTGCTCG 2041 TGCCGTGGAC ACACGGCTCG AGGAACTGGG CGGGGAGCGG CTGCTGCAGC TGGGCCAGGG 2101 CGACGAGCTG TGCGGCCAGG AGGAGGCCTT CCGAGGCTGG GCCCAGGCTG CCTTCCAGGC 2161 CGCCTGTGAG ACCTTCTGTG TGGGAGAGGA TGCCAAGCCC GCCGCCCGAG ACATCTTCAG 2221 CCCCAAACGG AGCTGGAAGC GCCAGAGGTA CCGGCTGAGC GCCCAGGCCG AGGGCCTGCA WO 00/09525 PCT/US99/17712 EPI-109 669 2281 GTTGCTGCCA GGTCTGATCC ACGTGCACAG GCGGAAGATG TTCCAGGCTA CAATCCGCTC 2341 AGTGGAAAAC CTGCAAAGCA GCAAGTCCAC GAGGGCCACC ATCCTGGTGC GCCTGGACAC 2401 CGGAGGCCAG GAGGGGCTGC AGTACCAGCC GGGGGACCAC ATAGGTGTCT GCCCGCCCAA 2461 CCGGCCCGGC CTTGTGGAGG CGCTGCTGAG CCGCGTGGAG GACCCGCCGG CGCCCACTGA 2521 GCCCGTGGCA GTAGAGCAGC TGGAGAAGGG CAGCCCTGGT GGCCCTCCCC CCGGCTGGGT 2581 GCGGGACCCC CGGCTGCCCC CGTGCACGCT GCGCCAGGCT CTCACCTTCT TCCTGGACAT 2641 CACCTCCCCA CCCAGCCCTC AGCTCTTGCG GCTGCTCAGC ACCTTGGCAG AAGAGCCCAG 2701 GGAACAGCAG GAGCTGGAGG CCCTCAGCCA GGATCCCCGA CGCTACGAGG AGTGGAAGTG 2761 GTTCCGCTGC CCCACGCTGC TGGAGGTGCT GGAGCAGTTC CCGTCGGTGG CGCTGCCTGC 2821 CCCACTGCTC CTCACCCAGC TGCCTCTGCT CCAGCCCCGG TACTACTCAG TCAGCTCGGC 2881 ACCCAGCACC CACCCAGGAG AGATCCACCT CACTGTAGCT GTGCTGGCAT ACAGGACTCA 2941 GGATGGGCTG GGCCCCCTGC ACTATGGAGT CTGCTCCACG TGGCTAAGCC AGCTCAAGCC 3001 CGGAGACCCT GTGCCCTGCT TCATCCGGGG GGCTCCCTCC TTCCGGCTGC CACCCGATCC 3061 CAGCTTGCCC TGCATCCTGG TGGGTCCAGG CACTGGCATT GCCCCCTTCC GGGGATTCTG 3121 GCAGGAGCGG CTGCATGACA TTGAGAGCAA AGGGCTGCAG CCCACTCCCA TGACTTTGGT 3181 GTTCGGCTGC CGATGCTCCC AACTTGACCA TCTCTACCGC GACGAGGTGC AGAACGCCCA 3241 GCAGCGCGGG GTGTTTGGCC GAGTCCTCAC CGCCTTCTCC CGGGAACCTG ACAACCCCAA 3301 GACCTACGTG CAGGACATCC TGAGGACGGA GCTGGCTGCG GAGGTGCACC GCGTGCTGTG 3361 CCTCGAGCGG GGCCACATGT TTGTCTGCGG CGATGTTACC ATGGCAACCA ACGTCCTGCA 3421 GACCGTGCAG CGCATCCTGG CGACGGAGGG CGACATGGAG CTGGACGAGG CCGGCGACGT 3481 CATCGGCGTG CTGCGGGATC AGCAACGCTA CCACGAAGAC ATTTTCGGGC TCACGCTGCG 3541 CACCCAGGAG GTGACAAGCC GCATACGCAC CCAGAGCTTT TCCTTGCAGG AGCGTCAGTT 3601 GCGGGGCGCA GTGCCCTGGG CGTTCGACCC TCCCGGCTCA GACACCAACA GCCCCTGAGA 3661 GCCGCCTGGC TTTCCCTTCC AGTTCCGGGA GAGCGGCTGC CCGACTCAGG TCCGCCCGAC 3721 CAGGATCAGC CCCGCTCCTC CCCTCTTGAG GTGGTGCCTT CTCACATCTG-TCCAGAGGCT 3781 GCAAGGATTC AGCATTATTC CTCCAGGAAG GAGCAAAACG CCTCTTTTCC CTCTCTAGGC 3841 CTGTTGCCTC GGGCCTGGGT CCGCCTTAAT CTGGAAGGCC CCTCCCAGCA GCGGTACCCC 3901 AGGGCCTACT GCCACCCGCT TCCTGTTTCT TAGTCCGAAT GTTAGATTCC TCTTGCCTCT 3961 CTCAGGAGTA TCTTACCTGT AAAGTCTAAT CTCTAAATCA AGTATTTATT ATTGAAGATT 4021 TACCATAAGG GACTGTGCCA GATGTTAGGA GAACTACTAA AGTGCCTACC CCAGCTC (2) INFORMATION FOR SEQ ID- NO:2510: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 11970 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2510: 1 AAGCTTCTAC CCTAGTCTGG TGCTACACTT ACATTGCTTA CATCCAAGTG TGGTTATTTC 61 TGTGGCTCCT GTTATAACTA TTATAGCACC AGGTCTATGA CCAGGAGAAT TAGACTGGCA 121 TTAAATCAGA ATAAGAGATT TTGCACCTGC AATAGACCTT ATGACACCTA ACCAACCCCA 181 TTATTTACAA TTAAACAGGA ACAGAGGGAA TACTTTATCC AACTCACACA AGCTGTTTTC 241 CTCCCAGATC CATGCTTTTT TGCGTTTATT ATTTTTTAGA GATGGGGGCT TCACTATGTT 301 GCCCACACTG GACTAAAACT CTGGGCCTCA AGTGATTGTC CTGCCTCAGC CTCCTGAATA 361 GCTGGGACTA CAGGGGCATG CCATCACACC TAGTTCATTT CCTCTATTTA AAATATACAT 421 GGCTTAAACT CCAACTGGGA ACCCAAAACA TTCATTTGCT AAGAGTCTGG TGTTCTACCA 481 CCTGAACTAG GCTGGCCACA GGAATTATAA AAGCTGAGAA ATTCTTTAAT AATAGTAACC 541 AGGCAACATC ATTGAAGGCT CATATGTAAA AATCCATGCC TTCCTTTCTC CCAATCTCCA 601 TTCCCAAACT TAGCCACTGG TTCTGGCTGA GGCCTTACGC ATACCTCCCG GGGCTTGCAC 661 ACACCTTCTT CTACAGAAGA CACACCTTGG GCATATCCTA CAGAAGACCA GGCTTCTCTC 721 TGGTCCTTGG TAGAGGGCTA CTTTACTGTA ACAGGGCCAG GGTGGAGAGT TCTCTCCTGA 781 AGCTCCATCC CCTCTATAGG AAATGTGTTG ACAATATTCA GAAGAGTAAG AGGATCAAGA 841 CTTCTTTGTG CTCAAATACC ACTGTTCTCT TCTCTACCCT GCCCTAACCA GGAGCTTGTC 901 ACCCCAAACT CTGAGGTGAT TTATGCCTTA ATCAAGCAAA CTTCCCTCTT CAGAAAAGAT 961 GGCTCATTTT CCCTCAAAAG TTGCCAGGAG CTGCCAAGTA TTCTGCCAAT TCACCCTGGA 1021 GCACAATCAA CAAATTCAGC CAGAACACAA CTACAGCTAC TATTAGAACT ATTATTATTA 1081 ATAAATTCCT CTCCAAATCT AGCCCCTTGA CTTCGGATTT CACGATTTCT CCCTTCCTCC 1141 TAGAAACTTG ATAAGTTTCC CGCGCTTCCC TTTTTCTAAG ACTACATGTT TGTCATCTTA 1201 TAAAGCAAAG GGGTGAATAA ATGAACCAAA TCAATAACTT CTGGAATATC TGCAAACAAC 1261 AATAATATCA GCTATGCCAT CTTTCACTAT TTTAGCCAGT ATCGAGTTGA ATGAACATAG 1321 AAAAATACAA AACTGAATTC TTCCCTGTAA ATTCCCCGTT TTGACGACGC ACTTGTAGCC 1381 ACGTAGCCAC GCCTACTTAA GACAATTACA AAAGGCGAAG AAGACTGACT CAGGCTTAAG 1441 CTGCCAGCCA GAGAGGGAGT CATTTCATTG GCGTTTGAGT CAGCAAAGGT ATTGTCCTCA 1501 CATCTCTGGC TATTAAAGTA TTTTCTGTTG TTGTTTTTCT CTTTGGCTGT TTTCTCTCAC 1561 ATTGCCTTCT CTAAAGCTAC AGTCTCTCCT TTCTTTTCTT GTCCCTCCCT GGTTTGGTAT 1621 GTGACCTAGA ATTACAGTCA GATTTCAGAA AATGATTCTC TCATTTTGCT GATAAGGACT 1681 GATTCGTTTT ACTGAGGGAC GGCAGAACTA GTTTCCTATG AGGGCATGGG TGAATACAAC 1741 TGAGGCTTCT CATGGGAGGG AATCTCTACT ATCCAAAATT ATTAGGAGAA AATTGAAAAT 1801 TTCCAACTCT GTCTCTCTCT TACCTCTGTG TAAGGCAAAT ACCTTATTCT TGTGGTGTTT WO 00/09525 PCT/US99/17712 EPI-109 670 1861 TTGTAACCTC TTCAAACTTT CATTGATTGA ATGCCTCTTC TGGCAATACA TTAGGTTGGG 1921 CACATAAGGA ATACCAACAT AAATAAAACA TTCTAAAAGA AGTTTACGAT CTAATAAAGG 1981 AGACAGGTAC ATAGCAAACT AATTCAAAGG AGCTAGAAGA TGGAGAAAAT GCTGAATGTG 2041 GACTAAGTCA TTCAACAAAG TTTTCAGGAA GCACAAAGAG GAGGGGCTCC CCTCACAGAT 2101 ATCTGGATTA GAGGCTGGCT GAGCTGATGG TGGCTGGTGT TCTCTGTTGC AGAAGTCAAG 2161 ATGGCCAAAG TTCCAGACAT CTTTGAAGAC CTGAAGAACT GTTACAGGTA AGGAATAAGA 2221 TTTATCTCTT GTGATTTAAT GAGGGTTTCA AGGCTCACCA GAATCCAGCT AGGCATAACA 2281 GTGGCCAGCA TGGGGCAGG CCGGCAGAGG TTGTAGAGAT GTGTACTAGT CCTGAAGTCA 2341 GAGCAGGTTC AGAGAAGACC CAGAAAAACT AAGCATTCAG CATGTTAAAC TGAGATTACA 2401 TTGGCAGGGA GACCGCCATT TTAGAAAAAT TATTTTTGAG GTCTGCTGAG CCCTACATGA 2461 ATATCAGCAT CAACTTAGAC ACAGCCTCTG TTGAGATCAC ATGCCCTGAT ATAAGAATGG 2521 GTTTTACTGG TCCATTCTCA GGAAAACTTG ATCTCATTCA GGAACAGGAA ATGGCTCCAC 2581 AGCAAGCTGG GCATGTGAAC TCACATATGC AGGCAAATCT CACTCAGATG TAGAAGAAAG 2641 GTAAATGAAC ACAAAGATAA AATTACGGAA CATATTAAAC TAACATGATG TTTCCATTAT 2701 CTGTAGTAAA TACTAACACA AACTAGGCTG TCAAAATTTT GCCTGGATAT TTTACTAAGT 2761 ATAAATTATG AAATCTGTTT TAGTGAATAC ATGAAAGTAA TGTGTAACAT ATAATCTATT 2821 TGGTTAAAAT AAAAAGGAAG TGCTTCAAAA CCTTTCTTTT CTCTAAAGGA GCTTAACATT 2881 CTTCCCTGAA CTTCAATTAA AGCTCTTCAA TTTGTTAGCC AAGTCCAATT TTTACAGATA 2941 AAGCACAGGT AAAGCTCAAA GCCTGTCTTG ATGACTACTA ATTCCAGATT AGTAAGATAT 3001 GAATTACTCT ACCTATGTGT ATGTGTAGAA GTCCTTAAAT TTCAAAGATG ACAGTAATGG 3061 CCATGTGTAT GTGTGTGACC CACAACTATC ATGGTCATTA AAGTACATTG GCCAGAGACC 3121 ACATGAAATA ACAACAATTA CATTCTCATC ATCTTATTTT GACAGTGAAA ATGAAGAAGA 3181 CAGTTCCTCC ATTGATCATC TGTCTCTGAA TCAGGTAAGC AAATGACTGT AATTCTCATG 3241 GGACTGCTAT TCTTACACAG TGGTTTCTTC ATCCAAAGAG AACAGCAATG ACTTGAATCT 3301 TAAATACTTT TGTTTTACCC TCACTAGAGA TCCAGAGACC TGTCTTTCAT TATAAGTGAG 3361 ACCAGCTGCC TCTCTAAACT AATAGTTGAT GTGCATTGGC TTCTCCCAGA ACAGAGCAGA 3421 ACTATCCCAA ATCCCTGAGA ACTGGAGTCT CCTGGGGCAG GCTTCATCAG GATGTTAGTT 3481 ATGCCATCCT GAGAAAGCCC CGCAGGCCGC TTCACCAGGT GTCTGTCTCC TAACGTGATG 3541 TGTTGTGGTT GTCTTCTCTG ACACCAGCAT CAGAGGTTAG AGAAAGTCTC CAAACATGAA 3601 GCTGAGAGAG AGGAAGCAAG CCAGCTGAAA GTGAGAAGTC TACAGCCACT CATCAATCTG 3661 TGTTATTGTG TTTGGAGACC ACAAATAGAC ACTATAAGTA CTGCCTAGTA TGTCTTCAGT 3721 ACTGGCTTTA AAAGCTGTCC CCAAAGGAGT ATTTCTAAAA TATTTTGAGC ATTGTTAAGC 3781 AGATTTTTAA CCTCCTGAGA GGGAACTAAT TGGAAAGCTA CCACTCACTA CAATCATTGT 3841 TAACCTATTT AGTTACAACA TCTCATTTTT GAGCATGCAA ATAAATGAAA AAGTCTTCCT 3901 AAAAAAATCA TCTTTTTATC CTGGAAGGAG GAAGGAAGGT GAGACAAAAG GGAGAGAGGG 3961 AGGGAAGCCT AATGAAACAC CAGTTACCTA AGACCAGAAT GGAGATCCTC CTCACTACCT 4021 CTGTTGAATA CAGCACCTAC TGAAAGAACT TTCATTCCCT GACCATGAAC AGCCTCTCAG 4081 CTTCTGTTTT CCTTCCTCAC AGAAATCCTT CTATCATGTA AGCTATGGCC CACTCCATGA 4141 AGGCTGCATG GATCAATCTG TGTCTCTGAG TATCTCTGAA ACCTCTAAAA CATCCAAGCT 4201 TACCTTCAAG GAGAGCATGG TGGTAGTAGC AACCAACGGG AAGGTTCTGA AGAAGAGACG 4261 GTTGAGTTTA AGCCAATCCA TCACTGATGA TGACCTGGAG GCCATCGCCA ATGACTCAGA 4321 GGAAGGTAAG GGGTCAAGCA CAATAATATC TTTCTTTTAC AGTTTTAAGC AAGTAGGGAC 4381 AGTAGAATTT AGGGGAAAAT TAAACGTGGA GTCAGAATAA CAAGAAGACA ACCAAGCATT 4441 AGTCTGGTAA CTATACACAG GAAAATTAAT TTTTATCCTT CTCCAGGAGG GAGAAATGAG 4501 CAGTGGCCTG AATCGAGAAT ACTTGCTCAC AGCCATTATT TCTTAGCCAT ATTGTAAAGG 4561 TCGTGTGACT TTTAGCCTTT CAGGAGAAAG CAGTAATAAG ACCACTTACG AGCTATGTTC 4621 CTCTCATACT AACTATGCCT CCTTGGTCAT GTTACATAAT CTTTTCGTGA TTCAGTTTCC 4681 TCTACTGTAA AATGGAGATA ATCAGAATCC CCCACTCATT GGATTGTTGT AAAGATTAAG 4741 AGTCTCAGGC TTTACAGACT GAGCTAGCTG GGCCCTCCTG ACTGTTATAA AGATTAAATG 4801 AGTCAACATC CCCTAACTTC TGGACTAGAA TAATGTCTGG TACAAAGTAA GCACCCAATA 4861 AATGTTAGCT ATTACTATCA TTATTATTAT TATTTTATTT TTTTTTTTTG AGATGGAGTC 4921 TGGCTCTGTC ACCCAGGCTG GAGTGCAGTG GCACAATCTC GGCTCACTGC AAGCTCTGCC 4981 TCCTGGGTTC ATGCCATTCT CCTGCCTCAG CCTCCCGAGT AAGCTGGGAA TACAGGCACC 5041 CGCCACTGTT CCCGGCTAAT TTTTTGTATT TTTAGTAGAG ACGGAGTTTC ACCGTGGTCT 5101 CCATCTCCTC GTGATCCACC CACCTTGGCC TCCCAAAGTG CCGGGATTAC AGGCGTGAGC 5161 CACCGCGCCC GGCCTATTAT TATTATTATT ACTACTACTA CTACCTATAT GAATACTACC 5221 AGCAATACTA ATTTATTAAT GACTGGATTA TGTCTAAACC TCACAAGAAT CCTACCTTCT 5281 CATTTTACAT AAAAGGAAAC TAAGCTCATT GAGATAGGTA AACTGCCCAA TGGCATACAT 5341 CTGTAAGTGG GAGAGCCTCA AATCTAATTC AGTTCTACCT GAGTAAAAAA ATCATGGTTT 5401 CTCCTCCATC CCTTTACTGT ACAAGCCTCC ACATGAACTA TAAACCCAAT ATTCCTGTTT 5461 TTAAGATAAT ACCTAAGCAA TAACGCATGT TCACCTAGAA GGTTTTAAAA TGTAACAAAA 5521 TATAAGAAAA TAAAAATCAC TCATATCGTC AGTGAGAGTT TACTACTGCC AGCACTATGG 5581 TATGTTTCCT TAAAATCTTT GCTATACACA TACCTACATG TGAACAAATA TGTCTAACAT 5641 CAAGACCACA CTATTTACAA CTTTATATCC AGCTTTTCTT ACTTAGCAAT GTATTGAGGA 5701 CATTTTAGAG TGCCCGTTTT TCACCATTAT AAGCAATGCA ACAATGAACA TCTGTATAAA 5761 TAAATATTCA TTTCTCTCAC CCTTTATTTC CTTAGAATAT ATTCCTAGAA GTAGAATTTC 5821 CCAGAGCCAT GAGGATTTGT GACGCTATTG ATATGTGCCA CTTTGCACTC TCTGTGACAT 5881 ATATAATTAT TTTTAATGCA TTCATTTTTT TCTCAGAGT CATTCGTTTG AAAACATAGA WO 00/09525 PCT/US99/17712 EPI-109 671 5941 CGGGAAATAC TGGTAGTCTT CCTTGTCAGT TAGAAACACC CAAACAATGA AAAATGAAAA 6001 AGTTGCACAA ATAGTCTCTA AAAACAATGA AACTATTGCC TGAGGAATTG AAGTTTAAAA 6061 AGAAGCACAT AAGCAACAAC AAGGATAATC CTAGAAAACC AGTTCTGCTG ACTGGGTGAT 6121 TTCACTTCTC TTTGCTTCCT CATCTGGATT GGAATATTCC TAATACCCCC TCCAGAACTA 6181 TTTTCCCTGT TTGTACTAGA CTGTGTATAT CATCTGTGTT TGTACATAGA CATTAATCTG 6241 CACTTGTGAT CATGGTTTTA GAAATCATCA AGCCTAGGTC ATCACCTTTT AGCTTCCTGA 6301 GCAATGTGAA ATACAACTTT ATGAGGATCA TCAAATACGA ATTCATCCTG AATGACGCCC 6361 TCAATCAAAG TATAATTCCA GCCAATGATC AGTACCTCAC GGCTGCTGCA TTACATAATC 6421 TGGATGAAGC AGGTACATTA AAATGGCACC AGACATTTCT GTCATCCTCC CCTCCTTTCA 6481 TTTACTTATT TATTTATTTC AATCTTTCTG CTTGCAAAAA ACATACCTCT TCAGAGTTCT 6541 GGGTTGCACA ATTCTTCCAG AATAGCTTGA AGCACAGCAC CCCCATAAAA ATCCCAAGCC 6601 AGGGCAGAAG GTTCAACTAA ATCTGGAAGT TCCACAAGAG AGAAGTTTCC TATCTTTGAG 6661 AGTAAAGGGT TGTGCACAAA GCTAGCTGAT GTACTACCTC TTTGGTTCTT TCAGACATTC 6721 TTACCCTCAA TTTTAAAACT GAGGAAACTG TCAGACATAT TAAATGATTT ACTCAGATTT 6781 ACCCAGAAGC CAATGAAGAA CAATCACTCT CCTTTAAAAA GTCTGTTGAT CAAACTCACA 6841 AGTAACACCA AACCAGGAAG ATCTTTATTA TCTCTGATAA CATATTTGTG AGGCAAAACC 6901 TCCAATAAGC TACAAATATG GCTTAAAGGA TGAAGTTTAG TGTCCAAAAA CTTTTATCAC 6961 ACACATCCAA TTTTCATGGC GGACATGTTT TAGTTTCAAC AGTATACATA TTTTCAAAGG 7021 TCCAGAGAGG CAATTTTGCA ATAAACAAGC AAGACTTTTT CTGATTGGAT GCACTTCAGC 7081 TAACATGCTT TCAACTCTAC ATTTACAAAT TATTTTGTGT TCTATTTTTC TACTTAATAT 7141 TATTTCTGCA ATTTTCCCAA TATTGACATC GTGTATGTAT TTGCCATTTT TAATATCACT 7201 AGACAATTCA ATCAGGTTGC TACGTTGGTC CCTTGGGTTT ACTCTAAATA GCTTGATTGC 7261 AAATATCTTT GTATATATTA TTGTTTTTTC TCCTATCTTG TAATTTCTTT GAGCACATCC 7321 CAAAGAGGAA TGCCTAGATC AATGGGCACA AATAATTTGA CAGCTCTTAT TAAACATTAT 7381 TCTGTAAGTA AAAACTGAAC TACTTTTCAG TATCACTAGC AACATATGAG TGTATCAGCT 7441 TCCTAAACCC CTCCATGTTA GGTCATTATG AACTTATGAT CTAACAAATT ACAGGGTCTT 7501 ATCCCACTAA TGAAATTATA AGAGATTCAA CACTTATTCA GCCCCGAAGG ATTCATTCAA 7561 CGTAGAAAAT TCTAAGAACA TTAACCAAGT ATTTACCTGC CTAGTGAGTG TGGAAGACAT 7621 TGTGAAGGAC ACAAAGATGT ATAGAATTCC ATTCCTGACT TCCAGGTATT TACACCATAG 7681 GTGGGGACCT AACTACACAC ACACACACAC ACACACACAC ACACACACAC ACCATGCACA 7741 CACAATCTAC ATCAACACTT GATTTTATAC AAATACAATG AATTTACTTT CTTTTTGGTT 7801 CTTCTCTTCA CCAGTGAAAT TTGACATGGG TGCTTATAAG TCATCAAAGG ATGATGCTAA 7861 AATTACCGTG ATTCTAAGAA TCTCAAAAAC TCAATTGTAT GTGACTGCCC AAGATGAAGA 7921 CCAACCAGTG CTGCTGAACG TCAGTTGTCC TTTGTCTCCA ACTTACCTTC ATTTACATCT 7981 CATATGTTTG TAAATAAGCC CAATAGGCAG ACACCTCTAA CAAGGTGACA CTGTCCTCTT 8041 TCCTTCCTAC CACAGCCCCC ACCTACCCAC CCCACTCCCA TTGATTCCAG AGGCGTGCCT 8101 AGGCAGGATC TATGAGAAAA TATAACAGAG AGTAAGAGGA AAATTACCTT CTTTCTTTTT 8161 CCTTTCCCTG CCTGACCTTA TTCACCTCCC ATCCCAGAGC ATCCATTTAT TCCATTGATC 8221 TTTACTGACA TCTATTATCT GACCTACACA ATACTAGACA TTAGGACAAT GTGGCCTGCC 8281 TCCAAGAAAC TCAAATAAGC CAACTGAGAT CAGAGAGGAT TAATCACCTG CCAATGGGCA 8341 CAAAGCAACA AGCTGGGAGC CAAGTCCCAA AATGGGGCCT GCTGCTTCCA GTTCCCCTCT 8401 CTCTGCATTG ATGTCAGCAT TATCCTTCGT CCCAGTCCTG TCTCCACTAC CACTTTCCCC 8461 CTCAAACACA CACACACACA ACAGCCTTAG ATGTTTTCTC CACTGATAAG TAGGTGACTC 8521 AATTTGTAAG TATATAATCC AAGACCTTCT ATTCCCAAGT AGAATTTATG TGCCTGCCTG 8581 TGCTTTTCTA CCTGGATCAA GTGATGTCTA CAGAGTAGGG CAGTAGCTTC ATTCATGAAC 8641 TCATTCAACA AGCATTATTC ACTGAGAGCC TTGTATTTTT CAGGCATAGT GCCAACAGCA 8701 GTGTGGACAG TGGTGCATCA AAGCCTCTAG TCTCATAGAA CTTAGTCTTC TGGAGGATAT 8761 GGAAAACAGA CAACCCAAAC AACCAACAAA AGAGCAAGAT GCTGCAAAAA AAAAAAAAAT 8821 GAATAGGGTG CTAAGATAGA GAAAAGTGGG AGAGTGCTAT TTAGACAAAG TGGTAAAAAC 8881 AAAGCCCCTT GTGAGATGAG AGCTGCCGAC AGAGGGGGCG GGTCATGGTT GTGGGTTTTT 8941 GGGTAGGACA TTCAGAGGAG GGGGCGGGTC GTGGTTGTGG GTTTTTGGGT AGGACATTCA 9001 GAGGAGGGGG CGGGTCGTGG TTGTGGGTTT TTGGGTAGGA CATTCAGAGG AGGGGGCGGG 9061 TCGTGGTTGT GGGTTTTTGG GTAGGACATT CAGAGGAGGG GGCGGGTCGT GGTTGTGGGT 9121 TTTTGGGACA TTCAGAGGAG TCTGAATGCA CCCAGGCCTA CAACTTCAAG ATGGTAAAGG 9181 ACAGCTCCAA GGATCAGAAG AAGCATTCTT GGAACTGGGG CATTTTGAGA AGGAGGAAAA 9241 ATATGCAGAG ACTAGTGCTT GCAGAGCTTG CATTTGGATT TCATTTGAGG TACAATGAAA 9301 ACCCATTAAT GGGTTTCACA CAGTGCAATG GCCTGACCTC ACTTATATTT CCTAAAATAG 9361 AAAACAGATC AGAAGGAAGG CAATAGAGAA GCAGAAAGTC CAATGAGGAG GTTTCACAGC 9421 AGTCATGGGG GTGGGGTAAG GAAAAGAAGT GGAAAGAAAC AGACAGAATT GGGTTATATT 9481 TTGGAGATAG AACCAACAGA AGGAAGAGGA GAAACAACAT TTACTGAGAA GGGAAAAAGT 9541 AGGAGAGGAA TAGGTTTGGG AAATAAATCC TGCTGACATT GGAAACCCCA AGGAAGCCTC 9601 AAAAGTATAT TTACTTGCTT TAGATTTAAA AGAATAGGAA AGAAGCATCT CAACTTGGAA 9661 TTTGAAATCT ATTTTTCCAT AAAAGTATTG TTAAATTCTA CTCATACTCA CAAGAAAAGT 9721 ACATTCTAAA GAGTATATTG AAAGAGTTTA CTGATATACT TAGGAATTTT GTGTGTATGT 9781 GTGTGTGTGT ATGTGTGTGT GTGTGTTTAA CCTTCAATTG TTGACTTAAA TACTGAGATA 9841 AATGTCATCT AAATGCTAAA TTGATTTCCC AAAGGTATGA TTTGTTCACT TGGAGATCAA 9901 AATGTTTAGG GGGCTTAGAA TCACTGTAGT GCTCAGATTT GATGCAAAAT GTCTTAGGCC 9961 TATGTTGAAG GCAGGACAGA AACAATGTTT CCCTCCTACC TGCCTGGATA CAGTAAGATA WO 00/09525 PCT/US99/17712 EPI-109 672 10021 CTAGTGTCAC TGACAATCTT CATAACTAAT TTAGATCTCT CTCCAATCAA CTAAGGAAAT 10081 CAACTCTTAT TAATAGACTG GGCCACACAT CTACTAGGCA TGTAATAAAT GCTTGCTGAA 10141 TGAACAAATG AATGAAGAGC CTATAGCATC ATGTTACAGC CATAGTCCTA AAGTGGTGTT 10201 TCTCATGAAG GCCAAATGCT AAGGGATTGA GCTTCAGTCC TTTTTCTAAC ATCTTGTTCT 10261 CTAACAGAAT TCTCTTCTTT TCTTCATAGG AGATGCCTGA GATACCCAAA ACCATCACAG 10321 GTAGTGAGAC CAACCTCCTC TTCTTCTGGG AAACTCACGG CACTAAGAAC TATTTCACAT 10381 CAGTTGCCCA TCCAAACTTG TTTATTGCCA CAAAGCAAGA CTACTGGGTG TGCTTGGCAG 10441 GGGGGCCACC CTCTATCACT GACTTTCAGA TACTGGAAAA CCAGGCGTAG GTCTGGAGTC 10501 TCACTTGTCT CACTTGTGCA GTGTTGACAG TTCATATGTA CCATGTACAT GAAGAAGCTA 10561 AATCCTTTAC TGTTAGTCAT TTGCTGAGCA TGTACTGAGC CTTGTAATTC TAAATGAATG 10621 TTTACACTCT TTGTAAGAGT GGAACCAACA CTAACATATA ATGTTGTTAT TTAAAGAACA 10681 CCCTATATTT TGCATAGTAC CAATCATTTT AATTATTATT CTTCATAACA ATTTTAGGAG 10741 GACCAGAGCT ACTGACTATG GCTACCAAAA AGACTCTACC CATATTACAG ATGGGCAAAT 10801 TAAGGCATAA GAAAACTAAG AAATATGCAC AATAGCAGTT GAAACAAGAA GCCACAGACC 10861 TAGGATTTCA TGATTTCATT TCAACTGTTT GCCTTCTGCT TTTAAGTTGC TGATGAACTC 10921 TTAATCAAAT AGCATAAGTT TCTGGGACCT CAGTTTTATC ATTTTCAAAA TGGAGGGAAT 10981 AATACCTAAG CCTTCCTGCC GCAACAGTTT TTTATGCTAA TCAGGGAGGT CATTTTGGTA 11041 AAATACTTCT CGAAGCCGAG CCTCAAGATG AAGGCAAAGC ACGAAATGTT ATTTTTTAAT 11101 TATTATTTAT ATATGTATTT ATAAATATAT TTAAGATAAT TATAATATAC TATATTTATG 11161 GGAACCCCTT CATCCTCTGA GTGTGACCAG GCATCCTCCA CAATAGCAGA CAGTGTTTTC 11221 TGGGATAAGT AAGTTTGATT TCATTAATAC AGGGCATTTT GGTCCAAGTT GTGCTTATCC 11281 CATAGCCAGG AAACTCTGCA TTCTAGTACT TGGGAGACCT GTAATCATAT AATAAATGTA 11341 CATTAATTAC CTTGAGCCAG TAATTGGTCC GATCTTTGAC TCTTTTGCCA TTAAACTTAC 11401 CTGGGCATTC TTGTTTCATT CAATTCCACC TGCAATCAAG TCCTACAAGC TAAAATTAGA 11461 TGAACTCAAC TTTGACAACC ATGAGACCAC TGTTATCAAA ACTTTCTTTT CTGGAATGTA 11521 ATCAATGTTT CTTCTAGGTT CTAAAAATTG TGATCAGACC ATAATGTTAC ATTATTATCA 11581 ACAATAGTGA TTGATAGAGT GTTATCAGTC ATAACTAAAT AAAGCTTGCA ACAAAATTCT 11641 CTGACACATA GTTATTCATT GCCTTAATCA TTATTTTACT GCATGGTAAT TAGGGACAAA 11701 TGGTAAATGT TTACATAAAT AATTGTATTT AGTGTTACTT TATAAAATCA AACCAAGATT 11761 TTATATTTTT TTCTCCTCTT TGTTAGCTGC CAGTATGCAT AAATGGCATT AAGAATGATA 11821 ATATTTCCGG GTTCACTTAA AGCTCATATT ACACATACAC AAAACATGTG TTCCCATCTT 11881 TATACAAACT CACACATACA GAGCTACATT AAAAACAACT AATAGGCCAG GCACGGTGGC 11941 TCAGACCTGT AATCCCAGCA CTTTGGGAGG (2) INFORMATION FOR SEQ ID NO:2511: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1497 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2511: 1 ACCAACCTCT TCGAGGCACA AGGCACAACA GGCTGCTCTG GGATTCTCTT CAGCCAATCT 61 TCATTGCTCA AGTGTCTGAA GCAGCCATGG CAGAAGTACC TGAGCTCGCC AGTGAAATGA 121 TGGCTTATTA CAGTGGCAAT GAGGATGACT TGTTCTTTGA AGCTGATGGC CCTAAACAGA 181 TGAAGTGCTC CTTCCAGGAC CTGGACCTCT GCCCTCTGGA TGGCGGCATC CAGCTACGAA 241 TCTCCGACCA CCACTACAGC AAGGGCTTCA GGCAGGCCGC GTCAGTTGTT GTGGCCATGG 301 ACAAGCTGAG GAAGATGCTG GTTCCCTGCC CACAGACCTT CCAGGAGAAT GACCTGAGCA 361 CCTTCTTTCC CTTCATCTTT GAAGAAGAAC CTATCTTCTT CGACACATGG GATAACGAGG 421 CTTATGTGCA CGATGCACCT GTACGATCAC TGAACTGCAC GCTCCGGGAC TCACAGCAAA 481 AAAGCTTGGT GATGTCTGGT CCATATGAAC TGAAAGCTCT CCACCTCCAG GGACAGGATA 541 TGGAGCAACA AGTGGTGTTC TCCATGTCCT TTGTACAAGG AGAAGAAAGT AATGACAAAA 601 TACCTGTGGC CTTGGGCCTC AAGGAAAAGA ATCTGTACCT GTCCTGCGTG TTGAAAGATG 661 ATAAGCCCAC TCTACAGCTG GAGAGTGTAG ATCCCAAAAA TTACCCAAAG AAGAAGATGG 721 AAAAGCGATT TGTCTTCAAC AAGATAGAAA TCAATAACAA GCTGGAATTT GAGTCTGCCC 781 AGTTCCCCAA CTGGTACATC AGCACCTCTC AAGCAGAAAA CATGCCCGTC TTCCTGGGAG 841 GGACCAAAGG CGGCCAGGAT ATAACTGACT TCACCATGCA ATTTGTGTCT TCCTAAAGAG 901 AGCTGTACCC AGAGAGTCCT GTGCTGAATG TGGACTCAAT CCCTAGGGCT GGCAGAAAGG 961 GAACAGAAAG GTTTTTGAGT ACGGCTATAG CCTGGACTTT CCTGTTGTCT ACACCAATGC 1021 CCAACTGCCT GCCTTAGGGT AGTGCTAAGA GGATCTCCTG TCCATCAGCC AGGACAGTCA 1081 GCTCTCTCCT TTCAGGGCCA ATCCCCAGCC CTTTTGTTGA GCCAGGCCTC TCTCACCTCT 1141 CCTACTCACT TAAAGCCCGC CTGACAGAAA CCACGGCCAC ATTTGGTTCT AAGAAACCCT 1201 CTGTCATTCG CTCCCACATT CTGATGAGCA ACCGCTTCCC TATTTATTTA TTTATTTGTT 1261 TGTTTGTTTT ATTCATTGGT CTAATTTATT CAAAGGGGGC AAGAAGTAGC AGTGTCTGTA 1321 AAAGAGCCTA GTTTTTAATA GCTATGGAAT CAATTCAATT TGGACTGGTG TGCTCTCTTT 1381 AAATCAAGTC CTTTAATTAA GACTGAAAAT ATATAAGCTC AGATTATTTA AATGGGAATA 1441 TTTATAAATG AGCAAATATC ATACTGTTCA ATGGTTCTGA AATAAACTTC TCTGAAG (2) INFORMATION FOR SEQ ID NO:2512: (T) SEQUENCE CHARACTERISTICS: WO 00/09525 PCT/US99/17712 EPI-109 673 (A) LENGTH: 9721 base pairs (B) TYPE: ncleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2512: 1 AGAAAGAAAG AGAGAGAGAA AGAAAAGAAA GAGGAAGGAA GGAAGGAAGG AAGAAAGACA 61 GGCTCTGAGG AAGGTGGCAG TTCCTACAAC GGGAGAACCA GTGGTTAATT TGCAAAGTGG 121 ATCCTGTGGA GGCANNCAGA GGAGTCCCCT AGGCCACCCA GACAGGGCTT TTAGCTATCT 181 GCAGGCCAGA CACCAAATTT CAGGAGGGCT CAGTGTTAGG AATGGATTAT GGCTTATCAA 241 ATTCACAGGA AACTAACATG TTGAACAGCT TTTAGATTTC CTGTGGAAAA TATAACTTAC 301 TAAAGATGGA GTTCTTGTGA CTGACTCCTG ATATCAAGAT ACTGGGAGCC AAATTAAAAA 361 TCAGAAGGCT GCTTGGAGAG CAAGTCCATG AAATGCTCTT TTTCCCACAG TAGAACCTAT 421 TTCCCTCGTG TCTCAAATAC TTGCACAGAG GCTCACTCCC TTGGATAATG CAGAGCGAGC 481 ACGATACCTG GCACATACTA ATTTGAATAA AATGCTGTCA AATTCCCATT CACCCATTCA 541 AGCAGCAAAC TCTATCTCAC CTGAATGTAC ATGCCAGGCA CTGTGCTAGA CTTGGCTCAA 601 AAAGATTTCA GTTTCCTGGA GGAACCAGGA GGGCAAGGTT TCAACTCAGT GCTATAAGAA 661 GTGTTACAGG CTGGACACGG TGGCTCACGC CTGTAATCCC AACATTTGGG AGGCCGAGGC 721 GGGCAGATCA CAAGGTCAGG AGATCGAGAC CATCCTGGCT AACATGGTGA AACCCTGTCT 781 CTACTAAAAA TACAAAAAAT TAGCCGGGCG TTGGCGGCAG GTGCCTGTAG TCCCAGCTGC 841 TGGGGAGGCT GAGGCAGGAG AATGGTGTGA ACCCGGGAGG CGGAACTTGC AGGGGGCCGA 901 GATCGTGCCA CTGCACTCCA GCCTGGGCGA CAGAGTGAGA CTCTGTCTCA AAAAAAAAAA 961 AAAAGTGTTA TGATGCAGAC CTGTCAAAGA GGCAAAGGAG GGTGTTCCTA CACTCCAGGC 1021 ACTGTTCATA ACCTGGACTC TCATTCATTC TACAAATGGA GGGCTCCCCT GGGCAGATCC 1081 CTGGAGCAGG CACTTTGCTG GTGTCTCGGT TAAAGAGAAA CTGATAACTC TTGGTATTAC 1141 CAAGAGATAG AGTCTCAGAT GGATATTCTT ACAGAAACAA TATTCCCACT TTTCAGAGTT 1201 CACCAAAAAA TCATTTTAGG CAGAGCTCAT CTGGCATTGA TCTGGTTCAT CCATGAGATT 1261 GGCTAGGGTA ACAGCACCTG GTCTTGCAGG GTTGTGTGAG CTTATCTCCA GGGTTGCCCC 1321 AACTCCGTCA GGAGCCTGAA CCCTGCATAC CGTATGTTCT CTGCCCCAGC CAAGAAAGGT 1381 CAATTTTCTC CTCAGAGGCT CCTGCAATTG ACAGAGAGCT CCCGAGGCAG AGAACAGCAC 1441 CCAAGGTAGA GACCCACACC CTCAATACAG ACAGGGAGGG CTATTGGCCC TTCATTGTAC 1501 CCATTTATCC ATCTGTAAGT GGGAAGATTC CTAAACTTAA GTACAAAGAA GTGAATGAAG 1561 AAAAGTATGT GCATGTATAA ATCTGTGTGT CTTCCACTTT GTCCCACATA TACTAAATTT 1621 AAACATTCTT CTAACGTGGG AAAATCCAGT ATTTTAATGT GGACATCAAC TGCACAACGA 1681 TTGTCAGGAA AACAATGCAT ATTTGCATGG TGATACATTT GCAAAATGTG TCATAGTTTG 1741 CTACTCCTTG CCCTTCCATG AACCAGAGAA TTATCTCAGT TTATTAGTCC CCTCCCCTAA 1801 GAAGCTTCCA CCAATACTCT TTTCCCCTTT CCTTTAACTT GATTGTGAAA TCAGGTATTC 1861 AACAGAGAAA TTTCTCAGCC TCCTACTTCT GCTTTTGAAA GCTATAAAAA CAGCGAGGGA 1921 GAAACTGGCA GATACCAAAC CTCTTCGAGG CACAAGGCAC AACAGGCTGC TCTGGGATTC 1981 TCTTCAGCCA ATCTTCATTG CTCAAGTATG ACTTTAATCT TCCTTACAAC TAGGTGCTAA 2041 GGGAGTCTCT CTGTCTCTCT GCCTCTTTGT GTGTATGCAT ATTCTCTCTC TCTCTCTCTT 2101 TCTTTCTCTG TCTCTCCTCT CCTTCCTCTC TGCCTCCTCT CTCAGCTTTT TGCAAAAATG 2161 CCAGGTGTAA TATAATGCTT ATGACTCGGG AAATATTCTG GGAATGGATA CTGCTTATCT 2221 AACAGCTGAC ACCCTAAAGG TTAGTGTCAA AGCCTCTGCT CCAGCTCTCC TAGCCAATAC 2281 ATTGCTAGTT GGGGTTTGGT TTAGCAAATG CTTTTCTCTA GACCCAAAGG ACTTCTCTTT 2341 CACACATTCA TTCATTTACT CAGAGATCAT TTCTTTGCAT GACTGCCATG CACTGGATGC 2401 TGAGAGAAAT CACACATGAA CGTAGCCGTC ATGGGGAAGT CACTCATTTT CTCCTTTTTA 2461 CACAGGTGTC TGAAGCAGCC ATGGCAGAAG TACCTGAGCT CGCCAGTGAA ATGATGGCTT 2521 ATTACAGGTC AGTGGAGACG CTGAGACCAG TAACATGAGC AGGTCTCCTC TTTCAAGAGT 2581 AGAGTGTTAT CTGTGCTTGG AGACCAGATT TTTCCCCTAA ATTGCCTCTT TCAGTGGCAA 2641 ACAGGGTGCC AAGTAAATCT GATTTAAAGA CTACTTTCCC ATTACAAGTC CCTCCAGCCT 2701 TGGGACCTGG AGGCTATCCA GATGTGTTGT TGCAAGGGCT TCCTGCAGAG GCAAATGGGG 2761 AGAAAAGATT CCAAGCCCAC AATACAAGGA ATCCCTTTGC AAAGTGTGGC TTGGAGGGAG 2821 AGGGAGAGCT CAGATTTTAG CTGACTCTGC TGGGCTAGAG GTTAGGCCTC AAGATCCAAC 2881 AGGGAGCACC AGGGTGCCCA CCTGCCAGGC CTAGAATCTG CCTTCTGGAC TGTTCTGCGC 2941 ATATCACTGT GAAACTTGCC AGGTGTTTCA GGCAGCTTTG AGAGGCAGGC TGTTTGCAGT 3001 TTCTTATGAA CAGTCAAGTC TTGTACACAG GGAAGGAAAA ATAAACCTGT TTAGAAGACA 3061 TAATTGAGAC ATGTCCCTGT TTTTATTACA GTGGCAATGA GGATGACTTG TTCTTTGAAG 3121 CTGATGGCCC TAAACAGATG AAGGTAAGAC TATGGGTTTA ACTCCCAACC CAAGGAAGGG 3181 CTCTAACACA GGGAAAGCTC AAAGAAGGGA GTTCTGGGCC ACTTTGATGC CATGGTATTT 3241 TGTTTTAGAA AGACTTTAAC CTCTTCCAGT GAGACACAGG CTGCACCACT TGCTGACCTG 3301 GCCACTTGGT CATCATATCA CCACAGTCAC TCACTAACGT TGGTGGTGGT GGCCACACTT 3361 GGTGGTGACA GGGGAGGAGT AGTGATAATG TTCCCATTTC ATAGTAGGAA GACAACCAAG 3421 TCTTCAACAT AAATTTGATT ATCCTTTTAA GAGATGGATT CAGCCTATGC CAATCACTTG 3481 AGTTAAACTC TGAAACCAAG AGATGATCTT GAGAACTAAC ATATGTCTAC CCCTTTTGAG 3541 TAGAATAGTT TTTTGCTACC TGGGGTGAAG CTTATAACAA CAAGACATAG ATGATATAAA 3601 CAAAAAGATG AATTGAGACT TGAAAGAAAA CCATTCACTT GCTGTTTGAC CTTGACAAGT 3661 CATTTTACCC GCTTTGGACC TCATCTGAAA AATAAAGGGC TGAGCTGGAT GATCTCTGAG 3721 ATTCCAGCAT CCTGCAACCT CCAGTTCTGA AATATTTTCA GTTGTAGCTA AGGGCATTTG 3781 GGCAGCAAAT GGTCATTTTT CAGACTCATC CTTACAAAGA GCCATGTTAT ATTCCTGCTG WO 00/09525 PCT/US99/17712 EPI-109 674 3841 TCCCTTCTGT TTTATATGAT GCTCAGTAGC CTTCCTAGGT GCCCAGCUAT CAGCCTAGCT 3901 AGGTCAGTTG TGCAGGTTGG AGGCAGCCAC TTTTCTCTGG CTTTATTTTA TTCCAGTTTG 3961 TGATAGCCTC CCCTAGCCTC ATAATCCAGT CCTCAATCTT GTTAAAAACA TATTTCTTTA 4021 GAAGTTTTAA GACTGGCATA ACTTCTTGGC TGCAGCTGTG GGAGGAGCCC ATTGGCTTGT 4081 CTGCCTGGCC TTTGCCCCCC ATTGCCTCTT CCAGCAGCTT GGCTCTGCTC CAGGCAGGAA 4141 ATTCTCTCCT GCTCAACTTT CTTTTGTGCA CTTACAGGTC TCTTTAACTG TCTTTCAAGC 4201 CTTTGAACCA TTATCAGCCT TAAGGCAACC TCAGTGAAGC CTTAATACGG AGCTTCTCTG 4261 AATAAGAGGA AAGTGGTAAC ATTTCACAAA AAGTACTCTC ACAGGATTTG CAGAATGCCT 4321 ATGAGACAGT GTTATGAAAA AGGAAAAAAA AGAACAGTGT AGAAAAATTG AATACTTGCT 4381 GAGTGAGCAT AGGTGAATGG AAAATGTTAT GGTCATCTGC ATGAAAAAGC AAATCATAGT 4441 GTGACAGCAT TAGGGATACA AAAAGATATA GAGAAGGTAT ACATGTATGG TGTAGGTGGG 4501 GCATGTACAA AAAGATGACA AGTAGAATCG GGATTTATTC TAAAGAATAG CCTGTAAGGT 4561 GTCCAGAAGC CACATTCTAG TCTTGAGTCT GCCTCTACCT GCTGTGTGCC CTTGAGTACA 4621 CCCTTAACCT CCTTGAGCTT CAGAGAGGGA TAATCTTTTT ATTTTATTTT ATTTTATTTT 4681 GTTTTGTTTT GTTTTGTTTT GTTTTATGAG ACAGAGTCTC ACTCTGTTGC CCAGGCTGGA 4741 GTGCAGTGGT ACAATCTTGG CTTACTGCAT CCTCCACCTC CTGAGTTCAA GCGATTCTCC 4801 TTCCTCAGTC TCCTGAATAG CTAGGATTAC AGGTGCACCC CACCACACCC AGCTAATTTT 4861 TGTATTTTTA GTAGAGAAGG GGTTTCGCCA TGTTGGCCAG GCTGGTTTTG AAGTCCTGAC 4921 CTAAATGATT CATCCACCTC GGCTTCCCAA AGTGCTGGGA TTACAGGCAT GAGCCACCAC 4981 GCCTGGCCCA GAGAGGGATG ATCTTTAGAA GCTCGGGATT CTTTCAAGCC CTTTCCTCCT 5041 CTCTGAGCTT TCTACTCTCT GATGTCAAAG CATGGTTCCT GGCAGGACCA CCTCACCAGG 5101 CTCCCTCCCT CGCTCTCTCC GCAGTGCTCC TTCCAGGACC TGGACCTCTG CCCTCTGGAT 5161 GGCGGCATCC AGCTACGAAT CTCCGACCAC CACTACAGCA AGGGCTTCAG GCAGGCCGCG 5221 TCAGTTGTTG TGGCCATGGA CAAGCTGAGG AAGATGCTGG TTCCCTGCCC ACAGACCTTC 5281 CAGGAGAATG ACCTGAGCAC CTTCTTTCCC TTCATCTTTG AAGAAGGTAG TTAGCCAAGA 5341 GCAGGCAGTA GATCTCCACT TGTGTCCTCT TGGAAGTCAT CAAGCCCCAG CCAACTCAAT 5401 TCCCCCAGAG CCAAAGCCCT TTAAAGGTAG AAGGCCCAGC GGGGAGACAA AACAAAGAAG 5461 GCTGGAAACC AAAGCAATCA TCTCTTTAGT GGAAACTATT CTTAAAGAAG ATCTTGATGG 5521 CTACTGACAT TTGCAACTCC CTCACTCTTT CTCAGGGGCC TTTCACTTAC ATTGTCACCA 5581 GAGGTTCGTA ACCTCCCTGT GGGCTAGTGT TATGACCATC ACCATTTTAC CTAAGTAGCT 5641 CTGTTGCTCG GCCACAGTGA GCAGTAATAG ACCTGAAGCT GGAACCCATG TCTAATAGTG 5701 TCAGGTCCAG TGTTCTTAGC CACCCCACTC CCAGCTTCAT CCCTACTGGT GTTGTCATCA 5761 GACTTTGACC GTATATGCTC AGGTGTCCTC CAAGAAATCA AATTTTGCCA CCTCGCCTCA 5821 CGAGGCCTGC CCTTCTGATT TTATACCTAA ACAACATGTG CTCCACATTT CAGAACCTAT 5881 CTTCTTCGAC ACATGGGATA ACGAGGCTTA TGTGCACGAT GCACCTGTAC GATCACTGAA 5941 CTGCACGCTC CGGGACTCAC AGCAAAAAAG CTTGGTGATG TCTGGTCCAT ATGAACTGAA 6001 AGCTCTCCAC CTCCAGGGAC AGGATATGGA GCAACAAGGT AAATGGAAAC ATCCTGGTTT 6061 CCCTGCCTGG CCTCCTGGCA GCTTGCTAAT TCTCCATGTT TTAAACAAAG TAGAAAGTTA 6121 ATTTAAGGCA AATGATCAAC ACAAGTGAAA AAAAATATTA AAAAGGAATA TACAAACTTT 6181 GGTCCTAGAA ATGGCACATT TGATTGCACT GGCCAGTGCA TTTGTTAACA GGAGTGTGAC 6241 CCTGAGAAAT TAGACGGCTC AAGCACTCCC AGGACCATGT CCACCCAAGT CTCTTGGGCA 6301 TAGTGCAGTG TCAATTCTTC CACAATATGG GGTCATTTGA TGGACATGGC CTAACTGCCT 6361 GTGGGTTCTC TCTTCCTGTT GTTGAGGCTG AAACAAGAGT GCTGGAGCGA TAATGTGTCC 6421 ATCCCCCTCC CCAGTCTTCC CCCCTTGCCC CAACATCCGT CCCACCCAAT GCCAGGTGGT 6481 TCCTTGTAGG GAAATTTTAC CGCCCAGCAG GAACTTATAT CTCTCCGCTG TAACGGGCAA 6541 AAGTTTCAAG TGCGGTGAAC CCATCATTAG CTGTGGTGAT CTGCCTGGCA TCGTGCCACA 6601 GTAGCCAAAG CCTCTGCACA GGAGTGTGGG CAACTAAGGC TGCTGACTTT GAAGGACAGC 6661 CTCACTCAGG GGGAAGCTAT TTGCTCTCAG CCAGGCCAAG AAAATCCTGT TTCTTTGGAA 6721 TCGGGTAGTA AGAGTGATCC CAGGGCCTCC AATTGACACT GCTGTGACTG AGGAAGATCA 6781 AAATGAGTGT CTCTCTTTGG AGCCACTTTC CCAGCTCAGC CTCTCCTCTC CCAGTTTCTT 6841 CCCATGGGCT ACTCTCTGTT CCTGAAACAG TTCTGGTGCC TGATTTCTGG CAGAAGTACA 6901 GCTTCACCTC TTTCCTTTCC TTCCACATTG ATCAAGTTGT TCCGCTCCTG TGGATGGGCA 6961 CATTGCCAGC CAGTGACACA ATGGCTTCCT TCCTTCCTTC CTTCAGCATT TAAAATGTAG 7021 ACCCTCTTTC ATTCTCCGTT CCTACTGCTA TGAGGCTCTG AGAAACCCTC AGGCCTTTGA 7081 GGGGAAACCC TAAATCAACA AAATGACCCT GCTATTGTCT GTGAGAAGTC AAGTTATCCT 7141 GTGTCTTAGG CCAAGGAACC TCACTGTGGG TTCCCACAGA GGCTACCAAT TACATGTATC 7201 CTACTCTCGG GGCTAGGGGT TGGGGTGACC CTGCATGCTG TGTCCCTAAC CACAAGACCC 7261 CCTTCTTTCT TCAGTGGTGT TCTCCATGTC CTTTGTACAA GGAGAAGAAA GTAATGACAA 7321 AATACCTGTG GCCTTGGGCC TCAAGGAAAA GAATCTGTAC CTGTCCTGCG TGTTGAAAGA 7381 TGATAAGCCC ACTCTACAGC TGGAGGTAAG TGAATGCTAT GGAATGAAGC CCTTCTCAGC 7441 CTCCTGCTAC CACTTATTCC CAGACAATTC ACCTTCTCCC CGCCCCCATC CCTAGGAAAA 7501 GCTGGGAACA GGTCTATTTG ACAAGTTTTG CATTAATGTA AATAAATTTA ACATAATTTT 7561 TAACTGCGTG CAACCTTCAA TCCTGCTGCA GAAAATTAAA TCATTTTGCC GATGTTATTA 7621 TGTCCTACCA TAGTTACAAC CCCAACAGAT TATATATTGT TAGGGCTGCT CTCATTTGAT 7681 AGACACCTTG GGAAATAGAT GACTTAAAGG GTCCCATTAT CACGTCCACT CCACTCCCAA 7741 AATCACCACC ACTATCACCT CCAGCTTTCT CAGCAAAAGC TTCATTTCCA AGTTGATGTC 7801 ATTCTAGGAC CATAAGGAAA AATACAATAA AAAGCCCCTG GAAACTAGGT ACTTCAAGAA 7861 GCTCTAGCTT AATTTTCACC CCCCCAAAAA AAAAAAATTC TCACCTACAT TATGCTCCTC WO 00/09525 PCT/US99/17712 EPI-109 675 7921 AGCATTTGGC ACTAAGTTTT AGAAAAGAAG AAGGGCTCTT TTAATAt-- am-qUAAAGT 7981 TGGGGGCCCA GTTACAACTC AGGAGTCTGG CTCCTGATCA TGTGACCTGC TCGTCAGTTT 8041 CCTTTCTGGC CAACCCAAAG AACATCTTTC CCATAGGCAT CTTTGTCCCT TGCCCCACAA 8101 AAATTCTTCT TTCTCTTTCG CTGCAGAGTG TAGATCCCAA AAATTACCCA AAGAAGAAGA 8161 TGGAAAAGCG ATTTGTCTTC AACAAGATAG AAATCAATAA CAAGCTGGAA TTTGAGTCTG 8221 CCCAGTTCCC CAACTGGTAC ATCAGCACCT CTCAAGCAGA AAACATGCCC GTCTTCCTGG 8281 GAGGGACCAA AGGCGGCCAG GATATAACTG ACTTCACCAT GCAATTTGTG TCTTCCTAAA 8341 GAGAGCTGTA CCCAGAGAGT CCTGTGCTGA ATGTGGACTC AATCCCTAGG GCTGGCAGAA 8401 AGGGAACAGA AAGGTTTTTG AGTACGGCTA TAGCCTGGAC TTTCCTGTTG TCTACACCAA 8461 TGCCCAACTG CCTGCCTTAG GGTAGTGCTA AGAGGATCTC CTGTCCATCA GCCAGGACAG 8521 TCAGCTCTCT CCTTTCAGGG CCAATCCCCA GCCCTTTTGT TGAGCCAGGC CTCTCTCACC 8581 TCTCCTACTC ACTTAAAGCC CGCCTGACAG AAACCACGGC CACATTTGGT TCTAAGAAAC 8641 CCTCTGTCAT TCGCTCCCAC ATTCTGATGA GCAACCGCTT CCCTATTTAT TTATTTATTT 8701 GTTTGTTTGT TTTGATTCAT TGGTCTAATT TATTCAAAGG GGGCAAGAAG TAGCAGTGTC 8761 TGTAAAAGAG CCTAGTTTTT AATAGCTATG GAATCAATTC AATTTGGACT GGTGTGCTCT 8821 CTTTAAATCA AGTCCTTTAA TTAAGACTGA AAATATATAA GCTCAGATTA TTTAAATGGG 8881 AATATTTATA AATGAGCAAA TATCATACTG TTCAATGGTT CTGAAATAAA CTTCACTGAA 8941 GAAAAAAAAA AAAGGGTCTC TCCTGATCAT TGACTGTCTG GATTGACACT GACAGTAAGC 9001 AAACAGGCTG TGAGAGTTCT TGGGACTAAG CCCACTCCTC ATTGCTGAGT GCTGCAAGTA 9061 CCTAGAAATA TCCTTGGCCA CCGAAGACTA TCCTCCTCAC CCATCCCCTT TATTTCGTTG 9121 TTCAACAGAA GGATATTCAG TGCACATCTG GAACAGGATC AGCTGAAGCA CTGCAGGGAG 9181 TCAGGACTGG TAGTAACAGC TACCATGATT TATCTATCAA TGCACCAAAC ATCTGTTGAG 9241 CAAGCGCTAT GTACTAGGAG CTGGGAGTAC AGAGATGAGA ACAGTCACAA GTCCCTCCTC 9301 AGATAGGAGA GGCAGCTAGT TATAAGCAGA ACAAGGTAAC ATGACAAGTA GAGTAAGATA 9361 GAAGAACGAA GAGGAGTAGC CAGGAAGGAG GGAGGAGAAC GACATAAGAA TCAAGCCTAA 9421 AGGGATAAAC AGAAGATTTC CACACATGGG CTGGGCCAAT TGGGTGTCGG TTACGCCTGT 9481 AATCCCAGCA CTTTGGGTGG CAGGGGCAGA AAGATCGCTT GAGCCCAGGA GTTCAAGACC 9541 AGCCTGGGCA ACATAGTGAG ACTCCCATCT CTACAAAAAA TAAATAAATA AATAAAACAA 9601 TCAGCCAGGC ATGCTGGCAT GCACCTGTAG TCCTAGCTAC TTGGGAAGCT GACACTGGAG 9661 GATTGCTTGA GCCCAGAAGT TCAAGACTGC AGTGAGCTTA TCCGTTGACC TGCAGGTCGA 9721 C (2) INFORMATION FOR SEQ ID NO:2513: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1496 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2513: 1 ACAAACCTTT TCGAGGCAAA AGGCAAAAAA GGCTGCTCTG GGATTCTCTT CAGCCAATCT 61 TCAATGCTCA AGTGTCTGAA GCAGCCATGG CAGAAGTACC TAAGCTCGCC AGTGAAATGA 121 TGGCTTATTA CAGTGGCAAT GAGGATGACT TGTTCTTTGA AGCTGATGGC CCTAAACAGA 181 TGAAGTGCTC CTTCCAGGAC CTGGACCTCT GCCCTCTGGA TGGCGGCATC CAGCTACGAA 241 TCTCCGACCA CCACTACAGC AAGGGCTTCA GGCAGGCCGC GTCAGTTGTT GTGGCCATGG 301 ACAAGCTGAG GAAGATGCTG GTTCCCTGCC CACAGACCTT CCAGGAGAAT GACCTGAGCA 361 CCTTCTTTCC CTTCATCTTT GAAGAAGAAC CTATCTTCTT CGACACATGG GATAACGAGG 421 CTTATGTGCA CGATGCACCT GTACGATCAC TGAACTGCAC GCTCCGGGAC TCACAGCAAA 481 AAAGCTTGGT GATGTCTGGT CCATATGAAC TGAAAGCTCT CCACCTCCAG GGACAGGATA 541 TGGAGCAACA AGTGGTGTTC TCCATGTCCT TTGTACAAGG AGAAGAAAGT AATGACAAAA 601 TACCTGTGGC CTTGGGCCTC AAGGAAAAGA ATCTGTACCT GTCCTGCGTG TTGAAAGATG 661 ATAAGCCCAC TCTACAGCTG GAGAGTGTAG ATCCCAAAAA TTACCCAAAG AAGAAGATGG 721 AAAAGCGATT TGTCTTCAAC AAGATAGAAA TCAATAACAA GCTGGAATTT GAGTCTGCCC 781 AGTTCCCCAA CTGGTACATC AGCACCTCTC AAGCAGAAAA CATGCCCGTC TTCCTGGGAG 841 GGACCAAAGG CGGCCAGGAT ATAACTGACT TCACCATGCA ATTTGTGTCT TCCTAAAGAG 901 AGCTGTACCC AGAGAGTCCT GTGCTGAATG TGGACTCAAT CCCTAGGGCT GGCAGAAAGG 961 GAACAGAAAG GTTTTTGAGT ACGGCTATAG CCTGGACTTT CCTGTTGTCT ACACCAATGC 1021 CCAACTGCCT GCCTTAGGGT AGTGCTAAGA GGATCTCCTG TCCATCAGCC AGGACAGTCA 1081 GCTCTCTCCT TTCAGGGCCA ATCCCAGCCC TTTTGTTGAG CCAGGCCTCT CTCACCTCTC 1141 CTACTCACTT AAAGCCCGCC TGACAGAAAC CAGGCCACAT TTTGGTTCTA AGAAACCCTC 1201 CTCTGTCATT CGCTCCCACA TTCTGATGAG CAACCGCTTC CCTATTTATT TATTTATTTG 1261 TTTGTTTGTT TTGATTCATT GGTCTAATTT ATTCAAAGGG GGCAAGAAGT AGCAGTGTCT 1321 GTAAAAGAGC CTAGTTTTTA ATAGCTATGG AATCAATTCA ATTTGGACTG GTGTGCTCTC 1381 TTTAAATCAA GTCCTTTAAT TAAGACTGAA AATATATAAG CTCAGATTAT TTAAATGGGA 1441 ATATTTATAA ATGAGCAAAT ATCATACTGT TCAATGGTTC TCAAATAAAC TTCACT (2) INFORMATION FOR SEQ ID NO:2514: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 720 base pairs (B) TYPE: nucleic acid WO 00/09525 PCTIUS99/17712 EPI-109 676 (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2514: 1 CTGGCAGGAG TAGCAGCTGC CCCTTGGCGC GACTGCTGGA GCCGCGAACT AGAGAAACAC 61 AGACACGCCT CATAGAGCAA CGGCGTCTCT CGGAGCGTGG AGCCCGCCAA GCTCGAGCTG 121 AGCTTTCGCT TGCCGTCCAC CACTGCCCAC ACTGTCGTTT GCTGCCATCG CAGACCTGCT 181 GCTGACTTCC ATCCCTCTGG ATCCGGCAAG GGCCTGCGAT TTTGACAATG TCAAGATTTA 241 CCGTATATCC CTGTTTGTTT GGATACACCA GTGACGTCCA CTTCTAGAAG ACAAAGTTAT 301 ATTACTTAAA CAACCAAAGA TATGAAACTA TCCATGAAGA ACAATATTAT CAATACACAG 361 CAGTCTTTTG TAACCATGCC CAATGTGATT GTACCAGATA TTGAAAAGGA AATACGAAGG 421 ATGGAAAATG GAGCATGCAG CTCCTTTTCT GAGGATGATG ACAGTGCCTC TACATCTGAA 481 GAATCAGAGA ATGAAAACCC TCATGCAAGG GGTTCCTTTA GTTATAAGTC ACTCAGAAAG 541 GGAGGACCAT CACAGAGGGA GCAGTACCTG CCTGGTGCCA TTGCCATTTT TAATGTGAAC 601 AACAGCGACA ATAAGGACCA GGAACCAGAA GAAAAAAAGA AAAAGAAAAA AGAAAAGAAG 661 AGCAAGTCAG ATGATAAAAA CGAAAATAAA AACGACCCAA AGAAGAAGAT GGAAAAGCGA (2) INFORMATION FOR SEQ ID NO:2515: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 2002 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2515: 1 atggccaaag ttccagacat gtttgaagac ctgaagaact gttacagtga aaatgaagaa 61 gacagttcct ccattgatca tctgtctctg aatcagaaat ccttctatca tgtaagctat 121 ggcccactcc atgaaggcrg catggatcaa tctgtgtctc tgagtatctc tgaaacctct 181 aaaacatcca agcttacctt caaggagagc atggtggtag tagcaaccaa cgggaaggt 241 ctgaagaaga gacggttgag tttaagccaa tccatcactg atgatgacct ggaggccatc 301 gccaatgact cagaggaaga aatcatcaag cctaggtcag caccttttag cttcctgagc 361 aatgtgaaat acaactttat gaggatcatc aaatacgaat tcatcctgaa tgacgccctc 421 aatcaaagta taattcgagc caatgatcag tacctcacgg ctgctgcatt acataatctg 481 gatgaagcag tgaaatttga catgggtgct tataagtcat caaaggatga tgctaaaatt 541 accgtgattc taagaatctc aaaaactcaa ttgtatgtga ctgcccaaga tgaagaccaa 601 ccagtgctgc tgaaggagat gcctgagata cccaaaacca tcacaggtag tgagaccaac 661 ctcctcttct tctgggaaac tcacggcact aagaactatt tcacatcagt tgcccatcca 721 aacttgttta ttgccacaaa gcaagactac tgggtgtgct tggcaggggg gccaccctct 781 atcactgact ttcagatact ggaaaaccag gcgtaggtct ggagtctcac ttgtctcact 841 tgtgcagtgt tgacagttca tatgtaccat gtacatgaag aagctaaatc ctttactgtt 901 agtcatttgc tgagcatgta ctgagccttg taattctaaa tgaatgttta cactctttgt 961 aagagtggaa ccaacactaa catataatgt tgttatttaa agaacaccct atattttgca 1021 tagtaccaat cattttaatt attattcttc ataacaattt taggaggacc agagctactg 1081 actatggcta ccaaaaagac tctacccata ttacagatgg gcaaattaag gcataagaaa 1141 actaagaaat atgcacaata gcagttgaaa caagaagcca cagacctagg atttcatgat 1201 ttcatttcaa ctgtttgcct tctgctttta agttgctgat gaactcttaa tcaaatagca 1261 taagtttctg ggacctcagt tttatcattt tcaaaatgga gggaataata cctaagcctt 1321 cctgccgcaa cagtttttta tgctaatcag ggaggtcatt ttggtaaaat acttctcgaa 1381 gccgagcctc aagatgaagg caaagcacga aatgttattt tttaattatt atttatatat 1441 gtatttataa atatatttaa gataattata atatactata tttatgggaa ccccttcatc 1501 ctctgagtgt gaccaggcat cctccacaat agcagacagt gttttctggg ataagtaagt 1561 ttgatttcat taatacaggg cattttggtc caagttgtgc ttatcccata gccaggaaac 1621 tctgcattct agtacttggg agacctgtaa tcatataata aatgtacatt aattaccttg 1681 agccagtaat tggtccgatc tttgactctt ttgccattaa acttacctgg gcattcttgt 1741 ttcattcaat tccacctgca atcaagtcct acaagctaaa attagatgaa ctcaactttg 1801 acaaccatag accactgtta tcaaaacttt cttttctgga atgtaatcaa tgtttcttct 1861 aggttctaaa aattgtgatc agaccataat gttacattat tatcaacaat agtgattgat 1921 agagtgttat cagtcataac taaataaagc ttgcaagtga gggagtcatt tcattggcgt 1981 ttgagtcagc aaagaagtca ag (2) INFORMATION FOR SEQ ID NO:2516: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 2027 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear )xi)SEQUENCE DESCRIPTION: SEQ ID NO:2516: 1 AGCTGCCAGC CAGAGAGGGA GTCATTTCAT TGGCGTTTGA GTCAGCAAAG AAGTCAAGAT 61 GGCCAAAGTT CCAGACATGT TTGAAGACCT GAAGAACTGT TACAGTGAAA ATGAAGAAGA 121 CAGTTCCTCC ATTGATCATC TGTCTCTGAA TCAGAAATCC TTCTATCATG TAAGCTATGG 181 CCCACTCCAT GAAGGCTGCA TGGATCAATC TGTGTCTCTG AGTATCTCTG AAACCTCTAA 241 AACATCCAAG CTTACCTTCA AGGAGAGCAT GGTGGTAGTA GCAACCAACG GGAAGGTTCT WO 00/09525 PCT/US99/17712 EPI-109 677 301 GAAGAAGAGA CGGTTGAGTT TAAGCCAATC CATCACTGAT GATGACC-ik AGGCCATCGC 361 CAATGACTCA GAGGAAGAAA TCATCAAGCC TAGGTCATCA CCTTTTAGCT TCCTGAGCAA 421 TGTGAAATAC AACTTTATGA GGATCATCAA ATACGAATTC ATCCTGAATG ACGCCCTCAA 481 TCAAAGTATA ATTCGAGCCA ATGATCAGTA CCTCACGGCT GCTGCATTAC ATAATCTGGA 541 TGAAGCAGTG AAATTTGACA TGGGTGCTTA TAAGTCATCA AAGGATGATG CTAAAATTAC 601 CGTGATTCTA AGAATCTCAA AAACTCAATT GTATGTGACT GCCCAAGATG AAGACCAACC 661 AGTGCTGCTG AAGGAGATGC CTGAGATACC CAAAACCATC ACAGGTAGTG AGACCAACCT 721 CCTCTTCTTC TGGGAAACTC ACGGCACTAA GAACTATTTC ACATCAGTTG CCCATCCAAA 781 CTTGTTTATT GCCACAAAGC AAGACTACTG GGTGTGCTTG GCAGGGGGGC CACCCTCTAT 841 CACTGACTTT CAGATACTGG AAAACCAGGC GTAGGTCTGG AGTCTCACTT GTCTCACTTG 901 TGCAGTGTTG ACAGTTCATA TGTACCATGT ACATGAAGAA GCTAAATCCT TTACTGTTAG 961 TCATTTGCTG AGCATGTACT GAGCCTTGTA ATTCTAAATG AATGTTTACA CTCTTTGTAA 1021 GAGTGGAACC AACACTAACA TATAATGTTG TTATTTAAAG AACACCCTAT ATTTTGCATA 1081 GTACCAATCA TTTTAATTAT TATTCTTCAT AACAATTTTA GGAGGACCAG AGCTACTGAC 1141 TATGGCTACC AAAAAGACTC TACCCATATT ACAGATGGGC AAATTAAGGC ATAAGAAAAC 1201 TAAGAAATAT GCACAATAGC AGTCGAAACA AGAAGCCACA GACCTAGGAT TTCATGATTT 1261 CATTTCAACT GTTTGCCTTC TGCTTTTAAG TTGCTGATGA ACTCTTAATC AAATAGCATA 1321 AGTTTCTGGG ACCTCAGTTT TATCATTTTC AAAATGGAGG GAATAATACC TAAGCCTTCC 1381 TGCCGCAACA GTTTTTTATG CTAATCAGGG AGGTCATTTT GGTAAAATAC TTCTCGAAGC 1441 CGAGCCTCAA GATGAAGGCA AAGCACGAAA TGTTATTTTT TAATTATTAT TTATATATGT 1501 ATTTATAAAT ATATTTAAGA TAATTATAAT ATACTATATT TATGGGAACC CCTTCATCCT 1561 CTGAGTGTGA CCAGGCATCC TCCACAATAG CAGACAGTGT TTTCTGGGAT AAGTAAGTTT 1621 GATTTCATTA ATACAGGGCA TTTTGGTCCA AGTTGTGCTT ATCCCATAGC CAGGAAACTC 1681 TGCATTCTAG TACTTGGGAG ACCTGTAATC ATATAATAAA TGTACATTAA TTACCTTGAG 1741 CCAGTAATTG GTCCGATCTT TGACTCTTTT GCCATTAAAC TTACCTGGGC ATTCTTGTTT 1801 CATTCAATTC CACCTGCAAT CAAGTCCTAC AAGCTAAAAT TAGATGAACT CAACTTTGAC 1861 AACCATGAGA CCACTGTTAT CAAAACTTTC TTTTCTGGAA TGTAATCAAT GTTTCTTCTA 1921 GGTTCTAAAA ATTGTGATCA GACCATAATG TTACATTATT ATCAACAATA GTGATTGATA 1981 GAGTGTTATC AGTCATAACT AAATAAAGCT TGCAACAAAA TTCTCTG (2) INFORMATION FOR SEQ ID NO:2517: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: base pairs (B) TYPE: 29433 nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2517: 1 AAGCTTCTAC CCTAGTCTGG TGCTACACTT ACATTGCTTA CATCCAAGTG TGGTTATTTC 61 TGTGGCTCCT GTTATAACTA TTATAGCACC AGGTCTATGA CCAGGAGAAT TAGACTGGCA 121 TTAAATCAGA ATAAGAGATT TTGCACCTGC AATAGACCTT ATGACACCTA ACCAACCCCA 181 TTATTTACAA TTAAACAGGA ACAGAGGGAA TACTTTATCC AACTCACACA AGCTGTTTTC 241 CTCCCAGATC CATGCTTTTT TGCGTTTATT ATTTTTTAGA GATGGGGGCT TCACTATGTT 301 GCCCACACTG GACTAAAACT CTGGGCCTCA AGTGATTGTC CTGCCTCAGC CTCCTGAATA 361 GCTGGGACTA CAGGGGCATG CCATCACACC TAGTTCATTT CCTCTATTTA AAATATACAT 421 GGCTTAAACT CCAACTGGGA ACCCAAAACA TTCATTTGCT AAGAGTCTGG TGTTCTACCA 481 CCTGAACTAG GCTGGCCACA GGAATTATAA AAGCTGAGAA ATTCTTTAAT AATAGTAACC 541 AGGCAACATC ATTGAAGGCT CATATGTAAA AATCCATGCC TTCCTTTCTC CCAATCTCCA 601 TTCCCAAACT TAGCCACTGG TTCTGGCTGA GGCCTTACGC ATACCTCCCG GGGCTTGCAC 661 ACACCTTCTT CTACAGAAGA CACACCTTGG GCATATCCTA CAGAAGACCA GGCTTCTCTC 721 TGGTCCTTGG TAGAGGGCTA CTTTACTGTA ACAGGGCCAG GGTGGAGAGT TCTCTCCTGA 781 AGCTCCATCC CCTCTATAGG AAATGTGTTG ACAATATTCA GAAGAGTAAG AGGATCAAGA 841 CTTCTTTGTG CTCAAATACC ACTGTTCTCT TCTCTACCCT GCCCTAACCA GGAGCTTGTC 901 ACCCCAAACT CTGAGGTGAT TTATGCCTTA ATCAAGCAAA CTTCCCTCTT CAGAAAAGAT 961 GGCTCATTTT CCCTCAAAAG TTGCCAGGAG CTGCCAAGTA TTCTGCCAAT TCACCCTGGA 1021 GCACAATCAA CAAATTCAGC CAGAACACAA CTACAGCTAC TATTAGAACT ATTATTATTA 1081 ATAAATTCCT CTCCAAATCT AGCCCCTTGA CTTCGGATTT CACGATTTCT CCCTTCCTCC 1141 TAGAAACTTG ATAAGTTTCC CGCGCTTCCC TTTTTCTAAG ACTACATGTT TGTCATCTTA 1201 TAAAGCAAAG GGGTGAATAA ATGAACCAAA TCAATAACTT CTGGAATATC TGCAAACAAC 1261 AATAATATCA GCTATGCCAT CTTTCACTAT TTTAGCCAGT ATCGAGTTGA ATGAACATAG 1321 AAAAATACAA AACTGAATTC TTCCCTGTAA ATTCCCCGTT TTGACGACGC ACTTGTAGCC 1381 ACGTAGCCAC GCCTACTTAA GACAATTACA AAAGGCGAAG AAGACTGACT CAGGCTTAAG 1441 CTGCCAGCCA GAGAGGGAGT CATTTCATTG GCGTTTGAGT CAGCAAAGGT ATTGTCCTCA 1501 CATCTCTGGC TATTAAAGTA TTTTCTGTTG TTGTTTTTCT CTTTGGCTGT TTTCTCTCAC 1561 ATTGCCTTCT CTAAAGCTAC AGTCTCTCCT TTCTTTTCTT GTCCCTCCCT GGTTTGGTAT 1621 GTGACCTAGA ATTACAGTCA GATTTCAGAA AATGATTCTC TCATTTTGCT GATAAGGACT 1681 GATTCGTTTT ACTGAGGGAC GGCAGAACTA GTTTCCTATG AGGGCATGGG TGAATACAAC 1741 TGAGGCTTCT CATGGGAGGG AATCTCTACT ATCCAAAATT ATTAGGAGAA AATTGAAAAT 1801 TTCCAACTCT GTCTCTCTCT TACCTCTGTG TAAGGCAAAT ACCTTATTCT TGTGGTGTTT 1861 TTGTAACCTC TTCAAACTTT CATTGATTGA ATGCCTGTTC TGGCAATACA TTAGGTTGGG WO 00/09525 PCT/US99/17712 EPI-109 678 1921 CACATAAGGA ATACCAACAT AAATAAAACA TTCTAAAAGA AGTTTACGAT CTAATAAAGG 1981 AGACAGGTAC ATAGCAAACT AATTCAAAGG AGCTAGAAGA TGGAGAAAAT GCTGAATGTG 2041 GACTAAGTCA TTCAACAAAG TTTTCAGGAA GCACAAAGAG GAGGGGCTCC CCTCACAGAT 2101 ATCTGGATTA GAGGCTGGCT GAGCTGATGG TGGCTGGTGT TCTCTCTTGC AGAAGTCAAG 2161 ATGGCCAAAG TTCCAGACAT GTTTGAAGAC CTGAAGAACT GTTACAGGTA AGGAATAAGA 2221 TTTATCTCTT GTGATTTAAT GAGGGTTTCA AGGCTCACCA GAATCCAGCT AGGCATAACA 2281 GTGGCCAGCA TGGGGGCAGG CCGGCAGAGG TTGTAGAGAT GTGTACTAGT CCTGAAGTCA 2341 GAGCAGGTTC AGAGAAGACC CAGAAAAACT AAGCATTCAG CATGTTAAAC TGAGATTACA 2401 TTGGCAGGGA GACCGCCATT TTAGAAAAAT TATTTTTGAG GTCTGCTGAG CCCTACATGA 2461 ATATCAGCAT CAACTTAGAC ACAGCCTCTG TTGAGATCAC ATGCCCTGAT ATAAGAATGG 2521 GTTTTACTGG TCCATTCTCA GGAAAACTTG ATCTCATTCA GGAACAGGAA ATGGCTCCAC 2581 AGCAAGCTGG GCATGTGAAC TCACATATGC AGGCAAATCT CACTCAGATG TAGAAGAAAG 2641 GTAAATGAAC ACAAAGATAA AATTACGGAA CATATTAAAC TAACATGATG TTTCCATTAT 2701 CTGTAGTAAA TACTAACACA AACTAGGCTG TCAAAATTTT GCCTGGATAT TTTACTAAGT 2761 ATAAATTATG AAATCTGTTT TAGTGAATAC ATGAAAGTAA TGTGTAACAT ATAATCTATT 2821 TGGTTAAAAT AAAAAGGAAG TGCTTCAAAA CCTTTCTTTT CTCTAAAGGA GCTTAACATT 2881 CTTCCCTGAA CTTCAATTAA AGCTCTTCAA TTTGTTAGCC AAGTCCAATT TTTACAGATA 2941 AAGCACAGGT AAAGCTCAAA GCCTGTCTTG ATGACTACTA ATTCCAGATT AGTAAGATAT 3001 GAATTACTCT ACCTATGTGT ATGTGTAGAA GTCCTTAAAT TTCAAAGATG ACAGTAATGG 3061 CCATGTGTAT GTGTGTGACC CACAACTATC ATGGTCATTA AAGTACATTG GCCAGAGACC 3121 ACATGAAATA ACAACAATTA CATTCTCATC ATCTTATTTT GACAGTGAAA ATGAAGAAGA 3181 CAGTTCCTCC ATTGATCATC TGTCTCTGAA TCAGGTAAGC AAATGACTGT AATTCTCATG 3241 GGACTGCTAT TCTTACACAG TGGTTTCTTC ATCCAAAGAG AACAGCAATG ACTTGAATCT 3301 TAAATACTTT TGTTTTACCC TCACTAGAGA TCCAGAGACC TGTCTTTCAT TATAAGTGAG 3361 ACCAGCTGCC TCTCTAAACT AATAGTTGAT GTGCATTGGC TTCTCCCACA ACAGAGCAGA 3421 ACTATCCCAA ATCCCTGAGA ACTGGAGTCT CCTGGGGCAG GCTTCATCAG GATGTTAGTT 3481 ATGCCATCCT GAGAAAGCCC CGCAGGCCGC TTCACCAGGT GTCTGTCTCC TAACGTGATG 3541 TGTTGTGGTT GTCTTCTCTG ACACCAGCAT CAGAGGTTAG AGAAAGTCTC CAAACATGAA 3601 GCTGAGAGAG AGGAAGCAAG CCAGCTGAAA GTGAGAAGTC TACAGCCACT CATCAATCTG 3661 TGTTATTGTG TTTGGAGACC ACAAATAGAC ACTATAAGTA CTGCCTAGTA TGTCTTCAGT 3721 ACTGGCTTTA AAAGCTGTCC CCAAAGGAGT ATTTCTAAAA TATTTTGAGC ATTGTTAAGC 3781 AGATTTTTAA CCTCCTGAGA GGGAACTAAT TGGAAAGCTA CCACTCACTA CAATCATTGT 3841 TAACCTATTT AGTTACAACA TCTCATTTTT GAGCATGCAA ATAAATGAAA AAGTCTTCCT 3901 AAAAAAATCA TCTTTTTATC CTGGAAGGAG GAAGGAAGGT GAGACAAAAG GGAGAGAGGG 3961 AGGGAAGCCT AATGAAACAC CAGTTACCTA AGACCAGAAT GGAGATCCTC CTCACTACCT 4021 CTGTTGAATA CAGCACCTAC TGAAAGAACT TTCATTCCCT GACCATGAAC AGCCTCTCAG 4081 CTTCTGTTTT CCTTCCTCAC AGAAATCCTT CTATCATGTA AGCTATGGCC CACTCCATGA 4141 AGGCTGCATG GATCAATCTG TGTCTCTGAG TATCTCTGAA ACCTCTAAAA CATCCAAGCT 4201 TACCTTCAAG GAGAGCATGG TGGTAGTAGC AACCAACGGG AAGGTTCTGA AGAAGAGACG 4261 GTTGAGTTTA AGCCAATCCA TCACTGATGA TGACCTGGAG GCCATCGCCA ATGACTCAGA 4321 GGAAGGTAAG GGGTCAAGCA CAATAATATC TTTCTTTTAC AGTTTTAAGC AAGTAGGGAC 4381 AGTAGAATTT AGGGGAAAAT TAAACGTGGA GTCAGAATAA CAAGAACACA ACCAAGCATT 4441 AGTCTGGTAA CTATACAGAG GAAAATTAAT TTTTATCCTT CTCCAGGAGG GAGAAATGAG 4501 CAGTGGCCTG AATCGAGAAT ACTTGCTCAC AGCCATTATT TCTTAGCCAT ATTGTAAAGG 4561 TCGTGTGACT TTTAGCCTTT CAGGAGAAAG CAGTAATAAG ACCACTTACG AGCTATGTTC 4621 CTCTCATACT AACTATGCCT CCTTGGTCAT GTTACATAAT CTTTTCGTGA TTCAGTTTCC 4681 TCTACTGTAA AATGGAGATA ATCAGAATCC CCCACTCATT GGATTGTTGT AAAGATTAAG 4741 AGTCTCAGGC TTTACAGACT GAGCTAGCTG GGCCCTCCTG ACTGTTATAA AGATTAAATG 4801 AGTCAACATC CCCTAACTTC TGGACTAGAA TAATGTCTGG TACAAAGTAA GCACCCAATA 4861 AATGTTAGCT ATTACTATCA TTATTATTAT TATTTTATTT TTTTTTTTTG AGATGGAGTC 4921 TGGCTCTGTC ACCCAGGCTG GAGTGCAGTG GCACAATCTC GGCTCACTGC AAGCTCTGCC 4981 TCCTGGGTTC ATGCCATTCT CCTGCCTCAG CCTCCCGAGT AAGCTGGGAA TACAGGCACC 5041 CGCCACTGTT CCCGGCTAAT TTTTTGTATT TTTAGTAGAG ACGGAGTTTC ACCGTGGTCT 5101 CCATCTCCTC GTGATCCACC CACCTTGGCC TCCCAAAGTG CCGGGATTAC AGGCGTGAGC 5161 CACCGCGCCC GGCCTATTAT TATTATTATT ACTACTACTA CTACCTATAT GAATACTACC 5221 AGCAATACTA ATTTATTAAT GACTGGATTA TGTCTAAACC TCACAAGAAT CCTACCTTCT 5281 CATTTTACAT AAAAGGAAAC TAAGCTCATT GAGATAGGTA AACTGCCCAA TGGCATACAT 5341 CTGTAAGTGG GAGAGCCTCA AATCTAATTC AGTTCTACCT GAGTAAAAAA ATCATGGTTT 5401 CTCCTCCATC CCTTTACTGT ACAAGCCTCC ACATGAACTA TAAACCCAAT ATTCCTGTTT 5461 TTAAGATAAT ACCTAAGCAA TAACGCATGT TCACCTAGAA GGTTTTAAAA TGTAACAAAA 5521 TATAAGAAAA TAAAAATCAC TCATATCGTC AGTGAGAGTT TACTACTGCC AGCACTATGG 5581 TATGTTTCCT TAAAATCTTT GCTATACACA TACCTACATG TGAACAAATA TGTCTAACAT 5641 CAAGACCACA CTATTTACAA CTTTATATCC AGCTTTTCTT ACTTAGCAAT GTATTGAGGA 5701 CATTTTAAG TGCCCGTTTT TCACCATTAT AAGCAATGCA ACAATGAACA TCTGTATAAA 5761 TAAATATTCA TTTCTCTCAC CCTTTATTTC CTTAGAATAT ATTCCTAGAA GTAGAATTTC 5821 CCAGAGCCAT GAGGATTTGT GACGCTATTG ATATGTGCCA CTTTGCACTC TCTGTGACAT 5881 ATATAATTAT TTTTAATGCA TTCATTTTTT TCTCAGAGTG CATTCGTTTC AAAACATAGA 5941 CGGGAAATAC TGGTAGTCTT CCTTGTCAGT TAAAACACC CAAACAATGA AAAATAAAA WO 00/09525 PCTIUS99/17712 EPI-109 679 6001 AGTTGCACAA ATAGTCTCTA AAAACAATGA AACTATTGCC TGAGGAAni±Lu AAGTTTAAAA 6061 AGAAGCACAT AAGCAACAAC AAGGATAATC CTAGAAAACC AGTTCTGCTG ACTGGGTGAT 6121 TTCACTTCTC TTTGCTTCCT CATCTGGATT GGAATATTCC TAATACCCCC TCCAGAACTA 6181 TTTTCCCTGT TTGTACTAGA CTGTGTATAT CATCTGTGTT TGTACATAGA CATTAATCTG 6241 CACTTGTGAT CATGGTTTTA GAAATCATCA AGCCTAGGTC ATCACCTTTT AGCTTCCTGA 6301 GCAATGTGAA ATACAACTTT ATGAGGATCA TCAAATACGA ATTCATCCTG AATGACGCCC 6361 TCAATCAAAG TATAATTCGA GCCAATGATC AGTACCTCAC GGCTGCTGCA TTACATAATC 6421 TGGATGAAGC AGGTACATTA AAATGGCACC AGACATTTCT GTCATCCTCC CCTCCTTTCA 6481 TTTACTTATT TATTTATTTC AATCTTTCTG CTTGCAAAAA ACATACCTCT TCAGAGTTCT 6541 GGGTTGCACA ATTCTTCCAG AATAGCTTGA AGCACAGCAC CCCCATAAAA ATCCCAAGCC 6601 AGGGCAGAAG GTTCAACTAA ATCTGGAAGT TCCACAAGAG AGAAGTTTCC TATCTTTGAG 6661 AGTAAAGGGT TGTGCACAAA GCTAGCTGAT GTACTACCTC TTTGGTTCTT TCAGACATTC 6721 TTACCCTCAA TTTTAAAACT GAGGAAACTG TCAGACATAT TAAATGATTT ACTCAGATTT 6781 ACCCAGAAGC CAATGAAGAA CAATCACTCT CCTTTAAAAA GTCTGTTGAT CAAACTCACA 6841 AGTAACACCA AACCAGGAAG ATCTTTATTA TCTCTGATAA CATATTTGTG AGGCAAAACC 6901 TCCAATAAGC TACAAATATG GCTTAAAGGA TGAAGTTTAG TGTCCAAAAA CTTTTATCAC 6961 ACACATCCAA TTTTCATGGC GGACATGTTT TAGTTTCAAC AGTATACATA TTTTCAAAGG 7021 TCCAGAGAGG CAATTTTGCA ATAAACAAGC AAGACTTTTT CTGATTGGAT GCACTTCAGC 7081 TAACATGCTT TCAACTCTAC ATTTACAAAT TATTTTGTGT TCTATTTTTC TACTTAATAT 7141 TATTTCTGCA ATTTTCCCAA TATTGACATC GTGTATGTAT TTGCCATTTT TAATATCACT 7201 AGACAATTCA ATCAGGTTGC TACGTTGGTC CCTTGGGTTT ACTCTAAATA GCTTGATTGC 7261 AAATATCTTT GTATATATTA TTGTTTTTTC TCCTATCTTG TAATTTCTTT GAGCACATCC 7321 CAAAGAGGAA TGCCTAGATC AATGGGCACA AATAATTTGA CAGCTCTTAT TAAACATTAT 7381 TCTGTAAGTA AAAACTGAAC TACTTTTCAG TATCACTAGC AACATATGAG TGTATCAGCT 7441 TCCTAAACCC CTCCATGTTA GGTCATTATG AACTTATGAT CTAACAAATT ACAGGGTCTT 7501 ATCCCACTAA TGAAATTATA AGAGATTCAA CACTTATTCA GCCCCGAAGG ATTCATTCAA 7561 CGTAGAAAAT TCTAAGAACA TTAACCAAGT ATTTACCTGC CTAGTGAGTG TGGAAGACAT 7621 TGTGAAGGAC ACAAAGATGT ATAGAATTCC ATTCCTGACT TCCAGGTATT TACACCATAG 7681 GTGGGGACCT AACTACACAC ACACACACAC ACACACACAC ACACACACAC ACCATGCACA 7741 CACAATCTAC ATCAACACTT GATTTTATAC AAATACAATG AATTTACTTT CTTTTTGGTT 7801 CTTCTCTTCA CCAGTGAAAT TTGACATGGG TGCTTATAAG TCATCAAAGG ATGATGCTAA 7861 AATTACCGTG ATTCTAAGAA TCTCAAAAAC TCAATTGTAT GTGACTGCCC AAGATGAAGA 7921 CCAACCAGTG CTGCTGAAGG TCAGTTGTCC TTTGTCTCCA ACTTACCTTC ATTTACATCT 7981 CATATGTTTG TAAATAAGCC CAATAGGCAG ACACCTCTAA CAAGGTGACA CTGTCCTCTT 8041 TCCTTCCTAC CACAGCCCCC ACCTACCCAC CCCACTCCCA TTGATTCCAG AGGCGTGCCT 8101 AGGCAGGATC TATGAGAAAA TATAACAGAG AGTAAGAGGA AAATTACCTT CTTTCTTTTT 8161 CCTTTCCCTG CCTGACCTTA TTCACCTCCC ATCCCAGAGC ATCCATTTAT TCCATTGATC 8221 TTTACTGACA TCTATTATCT GACCTACACA ATACTAGACA TTAGGACAAT GTGGCCTGCC 8281 TCCAAGAAAC TCAAATAAGC CAACTGAGAT CAGAGAGGAT TAATCACCTG CCAATGGGCA 8341 CAAAGCAACA AGCTGGGAGC CAAGTCCCAA AATGGGGCCT GCTGCTTCCA GTTCCCCTCT 8401 CTCTGCATTG ATGTCAGCAT TATCCTTCGT CCCAGTCCTG TCTCCACTAC CACTTTCCCC 8461 CTCAAACACA CACACACACA ACAGCCTTAG ATGTTTTCTC CACTGATAAG TAGGTGACTC 8521 AATTTGTAAG TATATAATCC AAGACCTTCT ATTCCCAAGT AGAATTTATG TGCCTGCCTG 8581 TGCTTTTCTA CCTGGATCAA GTGATGTCTA CAGAGTAGGG CAGTAGCTTC ATTCATGAAC 8641 TCATTCAACA AGCATTATTC ACTGAGAGCC TTGTATTTTT CAGGCATAGT GCCAACAGCA 8701 GTGTGGACAG TGGTGCATCA AAGCCTCTAG TCTCATAGAA CTTAGTCTTC TGGAGGATAT 8761 GGAAAACAGA CAACCCAAAC AACCAACAAA AGAGCAAGAT GCTGCAAAAA AAAAAAAAAT 8821 GAATAGGGTG CTAAGATAGA GAAAAGTGGG AGAGTGCTAT TTAGACAAAG TGGTAAAAAC 8881 AAAGCCCCTT GTGAGATGAG AGCTGCCGAC AGAGGGGGCG GGTCATGGTT GTGGGTTTTT 8941 GGGTAGGACA TTCAGAGGAG GGGGCGGGTC GTGGTTGTGG GTTTTTGGGT AGGACATTCA 9001 GAGGAGGGGG CGGGTCGTGG TTGTGGGTTT TTGGGTAGGA CATTCAGAGG AGGGGGCGGG 9061 TCGTGGTTGT GGGTTTTTGG GTAGGACATT CAGAGGAGGG GGCGGGTCGT GGTTGTGGGT 9121 TTTTGGGACA TTCAGAGGAG TCTGAATGCA CCCAGGCCTA CAACTTCAAG ATGGTAAAGG 9181 ACAGCTCCAA GGATCAGAAG AAGCATTCTT GGAACTGGGG CATTTTGAGA AGGAGGAAAA 9241 ATATGCAGAG ACTAGTGCTT GCAGAGCTTG CATTTGGATT TCATTTGAGG TACAATGAAA 9301 ACCCATTAAT GGGTTTCACA CAGTGCAATG GCCTGACCTC ACTTATATTT CCTAAAATAG 9361 AAAACAGATC AGAAGGAAGG CAATAGAGAA GCAGAAAGTC CAATGAGGAG GTTTCACAGC 9421 AGTCATGGGG GTGGGGTAAG GAAAAGAAGT GGAAAGAAAC AGACAGAATT GGGTTATATT 9481 TTGGAGATAG AACCAACAGA AGGAAGAGGA GAAACAACAT TTACTGAGAA GGGAAAAAGT 9541 AGGAGAGGAA TAGGTTTGGG AAATAAATCC TGCTGACATT GGAAACCCCA AGGAAGCCTC 9601 AAAAGTATAT TTACTTGCTT TAGATTTAAA AGAATAGGAA AGAAGCATCT CAACTTGGAA 9661 TTTGAAATCT ATTTTTCCAT AAAAGTATTG TTAAATTCTA CTCATACTCA CAAGAAAAGT 9721 ACATTCTAAA GAGTATATTG AAAGAGTTTA CTGATATACT TAGGAATTTT GTGTGTATGT 9781 GTGTGTGTGT ATGTGTGTGT GTGTGTTTAA CCTTCAATTG TTGACTTAAA TACTGAGATA 9841 AATGTCATCT AAATGCTAAA TTGATTTCCC AAAGGTATGA TTTGTTCACT TGGAGATCAA 9901 AATGTTTAGG GGGCTTAGAA TCACTGTAGT GCTCAGATTT GATGCAAAAT GTCTTAGGCC 9961 TATGTTGAAG GCAGGACAGA AACAATGTTT CCCTCCTACC TGCCTGGATA CAGTAAGATA 10021 CTAGTGTCAC TGACAATCTT CATAACTAAT TTAGATCTCT CTCCAATCAA CTAAGGAAAT WO 00/09525 PCT/US99/17712 EPI-109 680 10081 CAACTCTTAT TAATAGACTG GGCCACACAT CTACTAGGCA TGTAATAAAT GCTTGCTGAA 10141 TGAACAAATG AATGAAGAGC CTATAGCATC ATGTTACAGC CATAGTCCTA AAGTGGTGTT 10201 TCTCATGAAG GCCAAATGCT AAGGGATTGA GCTTCAGTCC TTTTTCTAAC ATCTTGTTCT 10261 CTAACAGAAT TCTCTTCTTT TCTTCATAGG AGATGCCTGA GATACCCAAA ACCATCACAG 10321 GTAGTGAGAC CAACCTCCTC TTCTTCTGGG AAACTCACGG CACTAAGAAC TATTTCACAT 10381 CAGTTGCCCA TCCAAACTTG TTTATTGCCA CAAAGCAAGA CTACTGGGTG TGCTTGGCAG 10441 GGGGGCCACC CTCTATCACT GACTTTCAGA TACTGGAAAA CCAGGCGTAG GTCTGGAGTC 10501 TCACTTGTCT CACTTGTGCA GTGTTGACAG TTCATATGTA CCATGTACAT GAAGAAGCTA 10561 AATCCTTTAC TGTTAGTCAT TTGCTGAGCA TGTACTGAGC CTTGTAATTC TAAATGAATG 10621 TTTACACTCT TTGTAAGAGT GGAACCAACA CTAACATATA ATGTTGTTAT TTAAAGAACA 10681 CCCTATATTT TGCATAGTAC CAATCATTTT AATTATTATT CTTCATAACA ATTTTAGGAG 10741 GACCAGAGCT ACTGACTATG GCTACCAAAA AGACTCTACC CATATTACAG ATGGGCAAAT 10801 TAAGGCATAA GAAAACTAAG AAATATGCAC AATAGCAGTT GAAACAAGAA GCCACAGACC 10861 TAGGATTTCA TGATTTCATT TCAACTGTTT GCCTTCTGCT TTTAAGTTGC TGATGAACTC 10921 TTAATCAAAT AGCATAAGTT TCTGGGACCT CAGTTTTATC ATTTTCAAAA TGGAGGGAAT 10981 AATACCTAAG CCTTCCTGCC GCAACAGTTT TTTATGCTAA TCAGGGAGGT CATTTTGGTA 11041 AAATACTTCT CGAAGCCGAG CCTCAAGATG AAGGCAAAGC ACGAAATGTT ATTTTTTAAT 11101 TATTATTTAT ATATGTATTT ATAAATATAT TTAAGATAAT TATAATATAC TATATTTATG 11161 GGAACCCCTT CATCCTCTGA GTGTGACCAG GCATCCTCCA CAATAGCAGA CAGTGTTTTC 11221 TGGGATAAGT AAGTTTGATT TCATTAATAC AGGGCATTTT GGTCCAAGTT GTGCTTATCC 11281 CATAGCCAGG AAACTCTGCA TTCTAGTACT TGGGAGACCT GTAATCATAT AATAAATGTA 11341 CATTAATTAC CTTGAGCCAG TAATTGGTCC GATCTTTGAC TCTTTTGCCA TTAAACTTAC 11401 CTGGGCATTC TTGTTTCATT CAATTCCACC TGCAATCAAG TCCTACAAGC TAAAATTAGA 11461 TGAACTCAAC TTTGACAACC ATGAGACCAC TGTTATCAAA ACTTTCTTTT CTGGAATGTA 11521 ATCAATGTTT CTTCTAGGTT CTAAAAATTG TGATCAGACC ATAATGTTAC ATTATTATCA 11581 ACAATAGTGA TTGATAGAGT GTTATCAGTC ATAACTAAAT AAAGCTTGCA ACAAAATTCT 11641 CTGACACATA GTTATTCATT GCCTTAATCA TTATTTTACT GCATGGTAAT TAGGGACAAA 11701 TGGTAAATGT TTACATAAAT AATTGTATTT AGTGTTACTT TATAAAATCA AACCAAGATT 11761 TTATATTTTT TTCTCCTCTT TGTTAGCTGC CAGTATGCAT AAATGGCATT AAGAATGATA 11821 ATATTTCCGG GTTCACTTAA AGCTCATATT ACACATACAC AAAACATGTG TTCCCATCTT 11881 TATACAAACT CACACATACA GAGCTACATT AAAAACAACT AATAGGCCAG GCACGGTGGC 11941 TCAGACCTGT AATCCCAGCA CTTTGGGAGG 1 ACCAACCTCT TCGAGGCACA AGGCACAACA GGCTGCTCTG GGATTCTCTT CAGCCAATCT 61 TCATTGCTCA AGTGTCTGAA GCAGCCATGG CAGAAGTACC TGAGCTCGCC AGTGAAATGA 121 TGGCTTATTA CAGTGGCAAT GAGGATGACT TGTTCTTTGA AGCTGATGGC CCTAAACAGA 181 TGAAGTGCTC CTTCCAGGAC CTGGACCTCT GCCCTCTGGA TGGCGGCATC CAGCTACGAA 241 TCTCCGACCA CCACTACAGC AAGGGCTTCA GGCAGGCCGC GTCAGTTGTT GTGGCCATGG 301 ACAAGCTGAG GAAGATGCTG GTTCCCTGCC CACAGACCTT CCAGGAGAAT GACCTGAGCA 361 CCTTCTTTCC CTTCATCTTT GAAGAAGAAC CTATCTTCTT CGACACATGG GATAACGAGG 421 CTTATGTGCA CGATGCACCT GTACGATCAC TGAACTGCAC GCTCCGGGAC TCACAGCAAA 481 AAAGCTTGGT GATGTCTGGT CCATATGAAC TGAAAGCTCT CCACCTCCAG GGACAGGATA 541 TGGAGCAACA AGTGGTGTTC TCCATGTCCT TTGTACAAGG AGAAGAAAGT AATGACAAAA 601 TACCTGTGGC CTTGGGCCTC AAGGAAAAGA ATCTGTACCT GTCCTGCGTG TTGAAAGATG 661 ATAAGCCCAC TCTACAGCTG GAGAGTGTAG ATCCCAAAAA TTACCCAAAG AAGAAGATGG 721 AAAAGCGATT TGTCTTCAAC AAGATAGAAA TCAATAACAA GCTGGAATTT GAGTCTGCCC 781 AGTTCCCCAA CTGGTACATC AGCACCTCTC AAGCAGAAAA CATGCCCGTC TTCCTGGGAG 841 GGACCAAAGG CGGCCAGGAT ATAACTGACT TCACCATGCA ATTTGTGTCT TCCTAAAGAG 901 AGCTGTACCC AGAGAGTCCT GTGCTGAATG TGGACTCAAT CCCTAGGGCT GGCAGAAAGG 961 GAACAGAAAG GTTTTTGAGT ACGGCTATAG CCTGGACTTT CCTGTTGTCT ACACCAATGC 1021 CCAACTGCCT GCCTTAGGGT AGTGCTAAGA GGATCTCCTG TCCATCAGCC AGGACAGTCA 1081 GCTCTCTCCT TTCAGGGCCA ATCCCCAGCC CTTTTGTTGA GCCAGGCCTC TCTCACCTCT 1141 CCTACTCACT TAAAGCCCGC CTGACAGAAA CCACGGCCAC ATTTGGTTCT AAGAAACCCT 1201 CTGTCATTCG CTCCCACATT CTGATGAGCA ACCGCTTCCC TATTTATTTA TTTATTTGTT 1261 TGTTTGTTTT ATTCATTGGT CTAATTTATT CAAAGGGGGC AAGAAGTAGC AGTGTCTGTA 1321 AAAGAGCCTA GTTTTTAATA GCTATGGAAT CAATTCAATT TGGACTGGTG TGCTCTCTTT 1381 AAATCAAGTC CTTTAATTAA GACTGAAAAT ATATAAGCTC AGATTATTTA AATGGGAATA 1441 TTTATAAATG AGCAAATATC ATACTGTTCA ATGGTTCTGA AATAAACTTC TCTGAAG 1 AGAAAGAAAG AGAGAGAGAA AGAAAAGAAA GAGGAAGGAA GGAAGGAAGG AAGAAAGACA 61 GGCTCTGAGG AAGGTGGCAG TTCCTACAAC GGGAGAACCA GTGGTTAATT TGCAAAGTGG 121. ATCCTGTGGA GGCANNCAGA GGAGTCCCCT AGGCCACCCA GACAGGGCTT TTAGCTATCT 181 GCAGGCCAGA CACCAAATTT CAGGAGGGCT CAGTGTTAGG AATGGATTAT GGCTTATCAA 241 ATTCACAGGA AACTAACATG TTGAACAGCT TTTAGATTTC CTGTGGAAAA TATAACTTAC 301 TAAAGATGGA GTTCTTGTGA CTGACTCCTG ATATCAAGAT ACTGGGAGCC AAATTAAAAA 361 TCAGAAGGCT GCTTGGAGAG CAAGTCCATG AAATGCTCTT TTTCCCACAG TAGAACCTAT 421 TTCCCTCGTG TCTCAAATAC TTGCACAGAG GCTCACTCCC TTGGATAATG CAGAGCGAGC 481 ACGATACCTG GCACATACTA ATTTGAATAA AATGCTGTCA AATTCCCATT CACCCATTCA 541 AGCAGCAAAC TCTATCTCAC CTGAATGTAC ATGCCAGGCA CTGTGCTAGA CTTGGCTCAA 601 AAAGATTTCA GTTTCCTGGA GGAACCAGGA GGGCAAGGTT TCAACTCAGT GCTATAAGAA WO 00/09525 PCT/US99/17712 EPI-109 681 661 GTGTTACAGG CTGGACACGG TGGCTCACGC CTGTAATCCC AACATTTGGG AGGCCGAGGC 721 GGGCAGATCA CAAGGTCAGG AGATCGAGAC CATCCTGGCT AACATGGTGA AACCCTGTCT 781 CTACTAAAAA TACAAAAAAT TAGCCGGGCG TTGGCGGCAG GTGCCTGTAG TCCCAGCTGC 841 TGGGGAGGCT GAGGCAGGAG AATGGTGTGA ACCCGGGAGG CGGAACTTGC AGGGGGCCGA 901 GATCGTGCCA CTGCACTCCA GCCTGGGCGA CAGAGTGAGA CTCTGTCTCA AAAAAAAAAA 961 AAAAGTGTTA TGATGCAGAC CTGTCAAAGA GGCAAAGGAG GGTGTTCCTA CACTCCAGGC 1021 ACTGTTCATA ACCTGGACTC TCATTCATTC TACAAATGGA GGGCTCCCCT GGGCAGATCC 1081 CTGGAGCAGG CACTTTGCTG GTGTCTCGGT TAAAGAGAAA CTGATAACTC TTGGTATTAC 1141 CAAGAGATAG AGTCTCAGAT GGATATTCTT ACAGAAACAA TATTCCCACT TTTCAGAGTT 1201 CACCAAAAAA TCATTTTAGG CAGAGCTCAT CTGGCATTGA TCTGGTTCAT CCATGAGATT 1261 GGCTAGGGTA ACAGCACCTG GTCTTGCAGG GTTGTGTGAG CTTATCTCCA GGGTTGCCCC 1321 AACTCCGTCA GGAGCCTGAA CCCTGCATAC CGTATGTTCT CTGCCCCAGC CAAGAAAGGT 1381 CAATTTTCTC CTCAGAGGCT CCTGCAATTG ACAGAGAGCT CCCGAGGCAG AGAACAGCAC 1441 CCAAGGTAGA GACCCACACC CTCAATACAG ACAGGGAGGG CTATTGGCCC TTCATTGTAC 1501 CCATTTATCC ATCTGTAAGT GGGAAGATTC CTAAACTTAA GTACAAAGAA GTGAATGAAG 1561 AAAAGTATGT GCATGTATAA ATCTGTGTGT CTTCCACTTT GTCCCACATA TACTAAATTT 1621 AAACATTCTT CTAACGTGGG AAAATCCAGT ATTTTAATGT GGACATCAAC TGCACAACGA 1681 TTGTCAGGAA AACAATGCAT ATTTGCATGG TGATACATTT GCAAAATGTG TCATAGTTTG 1741 CTACTCCTTG CCCTTCCATG AACCAGAGAA TTATCTCAGT TTATTAGTCC CCTCCCCTAA 1801 GAAGCTTCCA CCAATACTCT TTTCCCCTTT CCTTTAACTT GATTGTGAAA TCAGGTATTC 1861 AACAGAGAAA TTTCTCAGCC TCCTACTTCT GCTTTTGAAA GCTATAAAAA CAGCGAGGGA 1921 GAAACTGGCA GATACCAAAC CTCTTCGAGG CACAAGGCAC AACAGGCTGC TCTGGGATTC 1981 TCTTCAGCCA ATCTTCATTG CTCAAGTATG ACTTTAATCT TCCTTACAAC TAGGTGCTAA 2041 GGGAGTCTCT CTGTCTCTCT GCCTCTTTGT GTGTATGCAT ATTCTCTCTC TCTCTCTCTT 2101 TCTTTCTCTG TCTCTCCTCT CCTTCCTCTC TGCCTCCTCT CTCAGCTTTT TGCAAAAATG 2161 CCAGGTGTAA TATAATGCTT ATGACTCGGG AAATATTCTG GGAATGGATA CTGCTTATCT 2221 AACAGCTGAC ACCCTAAAGG TTAGTGTCAA AGCCTCTGCT CCAGCTCTCC TAGCCAATAC 2281 ATTGCTAGTT GGGGTTTGGT TTAGCAAATG CTTTTCTCTA GACCCAAAGG ACTTCTCTTT 2341 CACACATTCA TTCATTTACT CAGAGATCAT TTCTTTGCAT GACTGCCATG CACTGGATGC 2401 TGAGAGAAAT CACACATGAA CGTAGCCGTC ATGGGGAAGT CACTCATTTT CTCCTTTTTA 2461 CACAGGTGTC TGAAGCAGCC ATGGCAGAAG TACCTGAGCT CGCCAGTGAA ATGATGGCTT 2521 ATTACAGGTC AGTGGAGACG CTGAGACCAG TAACATGAGC AGGTCTCCTC TTTCAAGAGT 2581 AGAGTGTTAT CTGTGCTTGG AGACCAGATT TTTCCCCTAA ATTGCCTCTT TCAGTGGCAA 2641 ACAGGGTGCC AAGTAAATCT GATTTAAAGA CTACTTTCCC ATTACAAGTC CCTCCAGCCT 2701 TGGGACCTGG AGGCTATCCA GATGTGTTGT TGCAAGGGCT TCCTGCAGAG GCAAATGGGG 2761 AGAAAAGATT CCAAGCCCAC AATACAAGGA ATCCCTTTGC AAAGTGTGGC TTGGAGGGAG 2821 AGGGAGAGCT CAGATTTTAG CTGACTCTGC TGGGCTAGAG GTTAGGCCTC AAGATCCAAC 2881 AGGGAGCACC AGGGTGCCCA CCTGCCAGGC CTAGAATCTG CCTTCTGGAC TGTTCTGCGC 2941 ATATCACTGT GAAACTTGCC AGGTGTTTCA GGCAGCTTTG AGAGGCAGGC TGTTTGCAGT 3001 TTCTTATGAA CAGTCAAGTC TTGTACACAG GGAAGGAAAA ATAAACCTGT TTAGAAGACA 3061 TAATTGAGAC ATGTCCCTGT TTTTATTACA GTGGCAATGA GGATGACTTG TTCTTTGAAG 3121 CTGATGGCCC TAAACAGATG AAGGTAAGAC TATGGGTTTA ACTCCCAACC CAAGGAAGGG 3181 CTCTAACACA GGGAAAGCTC AAAGAAGGGA GTTCTGGGCC ACTTTGATGC CATGGTATTT 3241 TGTTTTAGAA AGACTTTAAC CTCTTCCAGT GAGACACAGG CTGCACCACT TGCTGACCTG 3301 GCCACTTGGT CATCATATCA CCACAGTCAC TCACTAACGT TGGTGGTGGT GGCCACACTT 3361 GGTGGTGACA GGGGAGGAGT AGTGATAATG TTCCCATTTC ATAGTAGGAA GACAACCAAG 3421 TCTTCAACAT AAATTTGATT ATCCTTTTAA GAGATGGATT CAGCCTATGC CAATCACTTG 3481 AGTTAAACTC TGAAACCAAG AGATGATCTT GAGAACTAAC ATATGTCTAC CCCTTTTGAG 3541 TAGAATAGTT TTTTGCTACC TGGGGTGAAG CTTATAACAA CAAGACATAG ATGATATAAA 3601 CAAAAAGATG AATTGAGACT TGAAAGAAAA CCATTCACTT GCTGTTTGAC CTTGACAAGT 3661 CATTTTACCC GCTTTGGACC TCATCTGAAA AATAAAGGGC TGAGCTGGAT GATCTCTGAG 3721 ATTCCAGCAT CCTGCAACCT CCAGTTCTGA AATATTTTCA GTTGTAGCTA AGGGCATTTG 3781 GGCAGCAAAT GGTCATTTTT CAGACTCATC CTTACAAAGA GCCATGTTAT ATTCCTGCTG 3841 TCCCTTCTGT TTTATATGAT GCTCAGTAGC CTTCCTAGGT GCCCAGCCAT CAGCCTAGCT 3901 AGGTCAGTTG TGCAGGTTGG AGGCAGCCAC TTTTCTCTGG CTTTATTTTA TTCCAGTTTG 3961 TGATAGCCTC CCCTAGCCTC ATAATCCAGT CCTCAATCTT GTTAAAAACA TATTTCTTTA 4021 GAAGTTTTAA GACTGGCATA ACTTCTTGGC TGCAGCTGTG GGAGGAGCCC ATTGGCTTGT 4081 CTGCCTGGCC TTTGCCCCCC ATTGCCTCTT CCAGCAGCTT GGCTCTGCTC CAGGCAGGAA 4141 ATTCTCTCCT GCTCAACTTT CTTTTGTGCA CTTACAGGTC TCTTTAACTG TCTTTCAAGC 4201. CTTTGAACCA TTATCAGCCT TAAGGCAACC TCAGTGAAGC CTTAATACGG AGCTTCTCTG 4261 AATAAGAGGA AAGTGGTAAC ATTTCACAAA AAGTACTCTC ACAGGATTTG CAGAATGCCT 4321 ATGAGACAGT GTTATGAAAA AGGAAAAAAA AGAACAGTGT AGAAAAATTG AATACTTGCT 4381 GAGTGAGCAT AGGTGAATGG AAAATGTTAT GGTCATCTGC ATGAAAAAGC AAATCATAGT 4441 GTGACAGCAT TAGGGATACA AAAAGATATA GAGAAGGTAT ACATGTATGG TGTAGGTGGG 4501 GCATGTACAA AAAGATGACA AGTAGAATCG GGATTTATTC TAAAGAATAG CCTGTAAGGT 4561 GTCCAGAAGC CACATTCTAG TCTTGAGTCT GCCTCTACCT GCTGTGTGCC CTTGAGTACA 4621 CCCTTAACCT CCTTGAGCTT CAGAGAGGGA TAATCTTTTT ATTTTATTTT ATTTTATTTT 4681 GTTTTGTTTT GTTTTGTTTT GTTTTATGAG ACAGAGTCTC ACTCTGTTGC CCAGGCTGGA WO 00/09525 PCT/US99/17712 EPI-109 682 4741 GTCCAGTGGT ACAATCTTGG CTTACTGCAT CCTCCACCTC CTGAGTTUAA GCGATTCTCC 4801 TTCCTCAGTC TCCTGAATAG CTAGGATTAC AGGTGCACCC CACCACACCC AGCTAATTTT 4861 TGTATTTTTA GTAGAGAAGG GGTTTCGCCA TGTTGGCCAG GCTGGTTTTG AAGTCCTGAC 4921 CTAAATGATT CATCCACCTC GGCTTCCCAA AGTGCTGGGA TTACAGGCAT GAGCCACCAC 4981 GCCTGGCCCA GAGAGGGATG ATCTTTAGAA GCTCGGGATT CTTTCAAGCC CTTTCCTCCT 5041 CTCTGAGCTT TCTACTCTCT GATGTCAAAG CATGGTTCCT GGCAGGACCA CCTCACCAGG 5101 CTCCCTCCCT CGCTCTCTCC GCAGTGCTCC TTCCAGGACC TGGACCTCTG CCCTCTGGAT 5161 GGCGGCATCC AGCTACGAAT CTCCGACCAC CACTACAGCA AGGGCTTCAG GCAGGCCGCG 5221 TCAGTTGTTG TGGCCATGGA CAAGCTGAGG AAGATGCTGG TTCCCTGCCC ACAGACCTTC 5281 CAGGAGAATG ACCTGAGCAC CTTCTTTCCC TTCATCTTTG AAGAAGGTAG TTAGCCAAGA 5341 GCAGGCAGTA GATCTCCACT TGTGTCCTCT TGGAAGTCAT CAAGCCCCAG CCAACTCAAT 5401 TCCCCCAGAG CCAAAGCCCT TTAAAGGTAG AAGGCCCAGC GGGGAGACAA AACAAAGAAG 5461 GCTGGAAACC AAAGCAATCA TCTCTTTAGT GGAAACTATT CTTAAAGAAG ATCTTGATGG 5521 CTACTGACAT TTGCAACTCC CTCACTCTTT CTCAGGGGCC TTTCACTTAC ATTGTCACCA 5581 GAGGTTCGTA ACCTCCCTGT GGGCTAGTGT TATGACCATC ACCATTTTAC CTAAGTAGCT 5641 CTGTTGCTCG GCCACAGTGA GCAGTAATAG ACCTGAAGCT GGAACCCATG TCTAATAGTG 5701 TCAGGTCCAG TGTTCTTAGC CACCCCACTC CCAGCTTCAT CCCTACTGGT GTTGTCATCA 5761 GACTTTGACC GTATATGCTC AGGTGTCCTC CAAGAAATCA AATTTTGCCA CCTCGCCTCA 5821 CGAGGCCTGC CCTTCTGATT TTATACCTAA ACAACATGTG CTCCACATTT CAGAACCTAT 5881 CTTCTTCGAC ACATGGGATA ACGAGGCTTA TGTGCACGAT GCACCTGTAC GATCACTGAA 5941 CTGCACGCTC CGGGACTCAC AGCAAAAAAG CTTGGTGATG TCTGGTCCAT ATGAACTGAA 6001 AGCTCTCCAC CTCCAGGGAC AGGATATGGA GCAACAAGGT AAATGGAAAC ATCCTGGTTT 6061 CCCTGCCTGG CCTCCTGGCA GCTTGCTAAT TCTCCATGTT TTAAACAAAG TAGAAAGTTA 6121 ATTTAAGGCA AATGATCAAC ACAAGTGAAA AAAAATATTA AAAAGGAATA TACAAACTTT 6181 GGTCCTAGAA ATGGCACATT TGATTGCACT GGCCAGTGCA TTTGTTAACA GGAGTGTGAC 6241 CCTGAGAAAT TAGACGGCTC AAGCACTCCC AGGACCATGT CCACCCAAGT CTCTTGGGCA 6301 TAGTGCAGTG TCAATTCTTC CACAATATGG GGTCATTTGA TGGACATGGC CTAACTGCCT 6361 GTGGGTTCTC TCTTCCTGTT GTTGAGGCTG AAACAAGAGT GCTGGAGCGA TAATGTGTCC 6421 ATCCCCCTCC CCAGTCTTCC CCCCTTGCCC CAACATCCGT CCCACCCAAT GCCAGGTGGT 6481 TCCTTGTAGG GAAATTTTAC CGCCCAGCAG GAACTTATAT CTCTCCGCTG TAACGGGCAA 6541 AAGTTTCAAG TGCGGTGAAC CCATCATTAG CTGTGGTGAT CTGCCTGGCA TCGTGCCACA 6601 GTAGCCAAAG CCTCTGCACA GGAGTGTGGG CAACTAAGGC TGCTGACTTT GAAGGACAGC 6661 CTCACTCAGG GGGAAGCTAT TTGCTCTCAG CCAGGCCAAG AAAATCCTGT TTCTTTGGAA 6721 TCGGGTAGTA AGAGTGATCC CAGGGCCTCC AATTGACACT GCTGTGACTG AGGAAGATCA 6781 AAATGAGTGT CTCTCTTTGG AGCCACTTTC CCAGCTCAGC CTCTCCTCTC CCAGTTTCTT 6841 CCCATGGGCT ACTCTCTGTT CCTGAAACAG TTCTGGTGCC TGATTTCTGG CAGAAGTACA 6901 GCTTCACCTC TTTCCTTTCC TTCCACATTG ATCAAGTTGT TCCGCTCCTG TGGATGGGCA 6961 CATTGCCAGC CAGTGACACA ATGGCTTCCT TCCTTCCTTC CTTCAGCATT TAAAATGTAG 7021 ACCCTCTTTC ATTCTCCGTT CCTACTGCTA TGAGGCTCTG AGAAACCCTC AGGCCTTTGA 7081 GGGGAAACCC TAAATCAACA AAATGACCCT GCTATTGTCT GTGAGAAGTC AAGTTATCCT 7141 GTGTCTTAGG CCAAGGAACC TCACTGTGGG TTCCCACAGA GGCTACCAAT TACATGTATC 7201 CTACTCTCGG GGCTAGGGGT TGGGGTGACC CTGCATGCTG TGTCCCTAAC CACAAGACCC 7261 CCTTCTTTCT TCAGTGGTGT TCTCCATGTC CTTTGTACAA GGAGAACAAA GTAATGACAA 7321 AATACCTGTG GCCTTGGGCC TCAAGGAAAA GAATCTGTAC CTGTCCTGCG TGTTGAAAGA 7381 TGATAAGCCC ACTCTACAGC TGGAGGTAAG TGAATGCTAT GGAATGAAGC CCTTCTCAGC 7441 CTCCTGCTAC CACTTATTCC CAGACAATTC ACCTTCTCCC CGCCCCCATC CCTAGGAAAA 7501 GCTGGGAACA GGTCTATTTG ACAAGTTTTG CATTAATGTA AATAAATTTA ACATAATTTT 7561 TAACTGCGTG CAACCTTCAA TCCTGCTGCA GAAAATTAAA TCATTTTGCC GATGTTATTA 7621 TGTCCTACCA TAGTTACAAC CCCAACAGAT TATATATTGT TAGGGCTGCT CTCATTTGAT 7681 AGACACCTTG GGAAATAGAT GACTTAAAGG GTCCCATTAT CACGTCCACT CCACTCCCAA 7741 AATCACCACC ACTATCACCT CCAGCTTTCT CAGCAAAAGC TTCATTTCCA AGTTGATGTC 7801 ATTCTAGGAC CATAAGGAAA AATACAATAA AAAGCCCCTG GAAACTAGGT ACTTCAAGAA 7861 GCTCTAGCTT AATTTTCACC CCCCCAAAAA AAAAAAATTC TCACCTACAT TATGCTCCTC 7921 AGCATTTGGC ACTAAGTTTT AGAAAAGAAG AAGGGCTCTT TTAATAATCA CACAGAAAGT 7981 TGGGGGCCCA GTTACAACTC AGGAGTCTGG CTCCTGATCA TGTGACCTGC TCGTCAGTTT 8041 CCTTTCTGGC CAACCCAAAG AACATCTTTC CCATAGGCAT CTTTGTCCCT TGCCCCACAA 8101 AAATTCTTCT TTCTCTTTCG CTGCAGAGTG TAGATCCCAA AAATTACCCA AAGAAGAAGA 8161 TGGAAAAGCG ATTTGTCTTC AACAAGATAG AAATCAATAA CAAGCTGGAA TTTGAGTCTG 8221 CCCAGTTCCC CAACTGGTAC ATCAGCACCT CTCAAGCAGA AAACATGCCC GTCTTCCTGG 8281. GAGGGACCAA AGGCGGCCAG GATATAACTG ACTTCACCAT GCAATTTGT TCTTCCTAAA 8341 GAGAGCTGTA CCCAGAGAGT CCTGTGCTGA ATGTGGACTC AATCCCTAGG GCTGGCAGAA 8401 AGGGAACAGA AAGGTTTTTG AGTACGGCTA TAGCCTGGAC TTTCCTGTTG TCTACACCAA 8461 TGCCCAACTG CCTGCCTTAG GGTAGTGCTA AGAGGATCTC CTGTCCATCA GCCAGGACAG 8521 TCAGCTCTCT CCTTTCAGGG CCAATCCCCA GCCCTTTTGT TGAGCCAGGC CTCTCTCACC 8581 TCTCCTACTC ACTTAAAGCC CCCCTGACAG AAACCACGGC CACATTTGGT TCTAAGAAAC 8641 CCTCTGTCAT TCGCTCCCAC ATTCTGATGA CAACCGCTT CCCTATTTAT TTATTTATTT 8701 GTTTGTTTGT TCTGATTCAT TGGTCTAATT TATTCAAAGG GGGCAAGAAC TAGCAGTCTC 8761 TGTAAAAGAG CCTAGTTTTT AATAGCTATG GAATCAATTC AATTTGACT GGTGTGCTCT WO 00/09525 PCT/US99/17712 EPI-109 683 8821 CTTTAAATCA AGTCCTTTAA TTAAGACTGA AAATATATAA GCTCAGATTA TTTAAATGGG 8881 AATATTTATA AATGAGCAAA TATCATACTG TTCAATGGTT CTGAAATAAA CTTCACTGAA 8941 GAAAAAAAAA AAAGGGTCTC TCCTGATCAT TGACTGTCTG GATTGACACT GACAGTAAGC 9001 AAACAGGCTG TGAGAGTTCT TGGGACTAAG CCCACTCCTC ATTGCTGAGT GCTGCAAGTA 9061 CCTAGAAATA TCCTTGGCCA CCGAAGACTA TCCTCCTCAC CCATCCCCTT TATTTCGTTG 9121 TTCAACAGAA GGATATTCAG TGCACATCTG GAACAGGATC AGCTGAAGCA CTGCAGGGAG 9181 TCAGGACTGG TAGTAACAGC TACCATGATT TATCTATCAA TGCACCAAAC ATCTGTTGAG 9241 CAAGCGCTAT GTACTAGGAG CTGGGAGTAC AGAGATGAGA ACAGTCACAA GTCCCTCCTC 9301 AGATAGGAGA GGCAGCTAGT TATAAGCAGA ACAAGGTAAC ATGACAAGTA GAGTAAGATA 9361 GAAGAACGAA GAGGAGTAGC CAGGAAGGAG GGAGGAGAAC GACATAAGAA TCAAGCCTAA 9421 AGGGATAAAC AGAAGATTTC CACACATGGG CTGGGCCAAT TGGGTGTCGG TTACGCCTGT 9481 AATCCCAGCA CTTTGGGTGG CAGGGGCAGA AAGATCGCTT GAGCCCAGGA GTTCAAGACC 9541 AGCCTGGGCA ACATAGTGAG ACTCCCATCT CTACAAAAAA TAAATAAATA AATAAAACAA 9601 TCAGCCAGGC ATGCTGGCAT GCACCTGTAG TCCTAGCTAC TTGGGAAGCT GACACTGGAG 9661 GATTGCTTGA GCCCAGAAGT TCAAGACTGC AGTGAGCTTA TCCGTTGACC TGCAGGTCGA 9721 C 1 ACAAACCTTT TCGAGGCAAA AGGCAAAAAA GGCTGCTCTG GGATTCTCTT CAGCCAATCT 61 TCAATGCTCA AGTGTCTGAA GCAGCCATGG CAGAAGTACC TAAGCTCGCC AGTGAAATGA 121 TGGCTTATTA CAGTGGCAAT GAGGATGACT TGTTCTTTGA AGCTGATGGC CCTAAACAGA 181 TGAAGTGCTC CTTCCAGGAC CTGGACCTCT GCCCTCTGGA TGGCGGCATC CAGCTACGAA 241 TCTCCGACCA CCACTACAGC AAGGGCTTCA GGCAGGCCGC GTCAGTTGTT GTGGCCATGG 301 ACAAGCTGAG GAAGATGCTG GTTCCCTGCC CACAGACCTT CCAGGAGAAT GACCTGAGCA 361 CCTTCTTTCC CTTCATCTTT GAAGAAGAAC CTATCTTCTT CGACACATGG GATAACGAGG 421 CTTATGTGCA CGATGCACCT GTACGATCAC TGAACTGCAC GCTCCGGGAC TCACAGCAAA 481 AAAGCTTGGT GATGTCTGGT CCATATGAAC TGAAAGCTCT CCACCTCCAG GGACAGGATA 541 TGGAGCAACA AGTGGTGTTC TCCATGTCCT TTGTACAAGG AGAAGAAAGT AATGACAAAA 601 TACCTGTGGC CTTGGGCCTC AAGGAAAAGA ATCTGTACCT GTCCTGCGTG TTGAAAGATG 661 ATAAGCCCAC TCTACAGCTG GAGAGTGTAG ATCCCAAAAA TTACCCAAAG AAGAAGATGG 721 AAAAGCGATT TGTCTTCAAC AAGATAGAAA TCAATAACAA GCTGGAATTT GAGTCTGCCC 781 AGTTCCCCAA CTGGTACATC AGCACCTCTC AAGCAGAAAA CATGCCCGTC TTCCTGGGAG 841 GGACCAAAGG CGGCCAGGAT ATAACTGACT TCACCATGCA ATTTGTGTCT TCCTAAAGAG 901 AGCTGTACCC AGAGAGTCCT GTGCTGAATG TGGACTCAAT CCCTAGGGCT GGCAGAAAGG 961 GAACAGAAAG GTTTTTGAGT ACGGCTATAG CCTGGACTTT CCTGTTGTCT ACACCAATGC 1021 CCAACTGCCT GCCTTAGGGT AGTGCTAAGA GGATCTCCTG TCCATCAGCC AGGACAGTCA 1081 GCTCTCTCCT TTCAGGGCCA ATCCCAGCCC TTTTGTTGAG CCAGGCCTCT CTCACCTCTC 1141 CTACTCACTT AAAGCCCGCC TGACAGAAAC CAGGCCACAT TTTGGTTCTA AGAAACCCTC 1201 CTCTGTCATT CGCTCCCACA TTCTGATGAG CAACCGCTTC CCTATTTATT TATTTATTTG 1261 TTTGTTTGTT TTGATTCATT GGTCTAATTT ATTCAAAGGG GGCAAGAAGT AGCAGTGTCT 1321 GTAAAAGAGC CTAGTTTTTA ATAGCTATGG AATCAATTCA ATTTGGACTG GTGTGCTCTC 1381 TTTAAATCAA GTCCTTTAAT TAAGACTGAA AATATATAAG CTCAGATTAT TTAAATGGGA 1441 ATATTTATAA ATGAGCAAAT ATCATACTGT TCAATGGTTC TCAAATAAAC TTCACT 1 CTGGCAGGAG TAGCAGCTGC CCCTTGGCGC GACTGCTGGA GCCGCGAACT AGAGAAACAC 61 AGACACGCCT CATAGAGCAA CGGCGTCTCT CGGAGCGTGG AGCCCGCCAA GCTCGAGCTG 121 AGCTTTCGCT TGCCGTCCAC CACTGCCCAC ACTGTCGTTT GCTGCCATCG CAGACCTGCT 181 GCTGACTTCC ATCCCTCTGG ATCCGGCAAG GGCCTGCGAT TTTGACAATG TCAAGATTTA 241 CCGTATATCC CTGTTTGTTT GGATACACCA GTGACGTCCA CTTCTAGAAG ACAAAGTTAT 301 ATTACTTAAA CAACCAAAGA TATGAAACTA TCCATGAAGA ACAATATTAT CAATACACAG 361 CAGTCTTTTG TAACCATGCC CAATGTGATT GTACCAGATA TTGAAAAGGA AATACGAAGG 421 ATGGAAAATG GAGCATGCAG CTCCTTTTCT GAGGATGATG ACAGTGCCTC TACATCTGAA 481 GAATCAGAGA ATGAAAACCC TCATGCAAGG GGTTCCTTTA GTTATAAGTC ACTCAGAAAG 541 GGAGGACCAT CACAGAGGGA GCAGTACCTG CCTGGTGCCA TTGCCATTTT TAATGTGAAC 601 AACAGCGACA ATAAGGACCA GGAACCAGAA GAAAAAAAGA AAAAGAAAAA AGAAAAGAAG 661 AGCAAGTCAG ATGATAAAAA CGAAAATAAA AACGACCCAA AGAAGAAGAT GGAAAAGCGA 1 ATGGCCAAAG TTCCAGACAT GTTTGAAGAC CTGAAGAACT GTTACAGTGA AAATGAAGAA 61 GACAGTTCCT CCATTGATCA TCTGTCTCTG AATCAGAAAT CCTTCTATCA TGTAAGCTAT 121 GGCCCACTCC ATGAAGGCTG CATGGATCAA TCTGTGTCTC TGAGTATCTC TGAAACCTCT 181 AAAACATCCA AGCTTACCTT CAAGGAGAGC ATGGTGGTAG TAGCAACCAA CGGGAAGGTT 241 CTGAAGAAGA GACGGTTGAG TTTAAGCCAA TCCATCACTG ATGATGACCT GGAGGCCATC 301 GCCAATGACT CAGAGGAAGA AATCATCAAG CCTAGGTCAG CACCTTTTAG CTTCCTGAGC 361 AATGTGAAAT ACAACTTTAT GAGGATCATC AAATACGAAT TCATCCTGAA TGACGCCCTC 421 AATCAAAGTA TAATTCGAGC CAATGATCAG TACCTCACGG CTGCTGCATT ACATAATCTG 481 GATGAAGCAG TGAAATTTGA CATGGGTGCT TATAAGTCAT CAAAGGATGA TGCTAAAATT 541 ACCGTGATTC TAAGAATCTC AAAAACTCAA TTGTATGTGA CTGCCCAAGA TGAAGACCAA 601 CCAGTGCTGC TGAAGGAGAT GCCTGAGATA CCCAAAACCA TCACAGGTAG TGAGACCAAC 661 CTCCTCTTCT TCTGGGAAAC TCACGGCACT AAGAACTATT TCACATCAGT TGCCCATCCA 721 AACTTGTTTA TTGCCACAAA GCAAGACTAC TGGGTGTGCT TGGCAGGGGG GCCACCCTCT 781 ATCACTGACT TTCAGATACT GGAAAACCAG GCGTAGGTCT GGAGTCTCAC TTGTCTCACT 841 TGTGCAGTGT TGACAGTTCA TATGTACCAT GTACATGAAG AAGCTAAATC CTTTACTGTT WO 00/09525 PCT/US99/17712 EPI-109 684 901 AGTCATTTGC TGAGCATGTA CTGAGCCTTG TAATTCTAAA TGAATGTTTA CACTCTTTGT 961 AAGAGTGGAA CCAACACTAA CATATAATGT TGTTATTTAA AGAACACCCT ATATTTTGCA 1021 TAGTACCAAT CATTTTAATT ATTATTCTTC ATAACAATTT TAGGAGGACC AGAGCTACTG 1081 ACTATGGCTA CCAAAAAGAC TCTACCCATA TTACAGATGG GCAAATTAAG GCATAAGAAA 1141 ACTAAGAAAT ATGCACAATA GCAGTTGAAA CAAGAAGCCA CAGACCTAGG ATTTCATGAT 1201 TTCATTTCAA CTGTTTGCCT TCTGCTTTTA AGTTGCTGAT GAACTCTTAA TCAAATAGCA 1261 TAAGTTTCTG GGACCTCAGT TTTATCATTT TCAAAATGGA GGGAATAATA CCTAAGCCTT 1321 CCTGCCGCAA CAGTTTTTTA TGCTAATCAG GGAGGTCATT TTGGTAAAAT ACTTCTCGAA 1381 GCCGAGCCTC AAGATGAAGG CAAAGCACGA AATGTTATTT TTTAATTATT ATTTATATAT 1441 GTATTTATAA ATATATTTAA GATAATTATA ATATACTATA TTTATGGGAA CCCCTTCATC 1501 CTCTGAGTGT GACCAGGCAT CCTCCACAAT AGCAGACAGT GTTTTCTGGG ATAAGTAAGT 1561 TTGATTTCAT TAATACAGGG CATTTTGGTC CAAGTTGTGC TTATCCCATA GCCAGGAAAC 1621 TCTGCATTCT AGTACTTGGG AGACCTGTAA TCATATAATA AATGTACATT AATTACCTTG 1681 AGCCAGTAAT TGGTCCGATC TTTGACTCTT TTGCCATTAA ACTTACCTGG GCATTCTTGT 1741 TTCATTCAAT TCCACCTGCA ATCAAGTCCT ACAAGCTAAA ATTAGATGAA CTCAACTTTG 1801 ACAACCATAG ACCACTGTTA TCAAAACTTT CTTTTCTGGA ATGTAATCAA TGTTTCTTCT 1861 AGGTTCTAAA AATTGTGATC AGACCATAAT GTTACATTAT TATCAACAAT AGTGATTGAT 1921 AGAGTGTTAT CAGTCATAAC TAAATAAAGC TTGCAAGTGA GGGAGTCATT TCATTGGCGT 1981 TTGAGTCAGC AAAGAAGTCA AG 1 AGCTGCCAGC CAGAGAGGGA GTCATTTCAT TGGCGTTTGA GTCAGCAAAG AAGTCAAGAT 61 GGCCAAAGTT CCAGACATGT TTGAAGACCT GAAGAACTGT TACAGTGAAA ATGAAGAAGA 121 CAGTTCCTCC ATTGATCATC TGTCTCTGAA TCAGAAATCC TTCTATCATG TAAGCTATGG 181 CCCACTCCAT GAAGGCTGCA TGGATCAATC TGTGTCTCTG AGTATCTCTG AAACCTCTAA 241 AACATCCAAG CTTACCTTCA AGGAGAGCAT GGTGGTAGTA GCAACCAACG GGAAGGTTCT 301 GAAGAAGAGA CGGTTGAGTT TAAGCCAATC CATCACTGAT GATGACCTGG AGGCCATCGC 361 CAATGACTCA GAGGAAGAAA TCATCAAGCC TAGGTCATCA CCTTTTAGCT TCCTGAGCAA 421 TGTGAAATAC AACTTTATGA GGATCATCAA ATACGAATTC ATCCTGAATG ACGCCCTCAA 481 TCAAAGTATA ATTCGAGCCA ATGATCAGTA CCTCACGGCT GCTGCATTAC ATAATCTGGA 541 TGAAGCAGTG AAATTTGACA TGGGTGCTTA TAAGTCATCA AAGGATGATG CTAAAATTAC 601 CGTGATTCTA AGAATCTCAA AAACTCAATT GTATGTGACT GCCCAAGATG AAGACCAACC 661 AGTGCTGCTG AAGGAGATGC CTGAGATACC CAAAACCATC ACAGGTAGTG AGACCAACCT 721 CCTCTTCTTC TGGGAAACTC ACGGCACTAA GAACTATTTC ACATCAGTTG CCCATCCAAA 781 CTTGTTTATT GCCACAAAGC AAGACTACTG GGTGTGCTTG GCAGGGGGGC CACCCTCTAT 841 CACTGACTTT CAGATACTGG AAAACCAGGC GTAGGTCTGG AGTCTCACTT GTCTCACTTG 901 TGCAGTGTTG ACAGTTCATA TGTACCATGT ACATGAAGAA GCTAAATCCT TTACTGTTAG 961 TCATTTGCTG AGCATGTACT GAGCCTTGTA ATTCTAAATG AATGTTTACA CTCTTTGTAA 1021 GAGTGGAACC AACACTAACA TATAATGTTG TTATTTAAAG AACACCCTAT ATTTTGCATA 1081 GTACCAATCA TTTTAATTAT TATTCTTCAT AACAATTTTA GGAGGACCAG AGCTACTGAC 1141 TATGGCTACC AAAAAGACTC TACCCATATT ACAGATGGGC AAATTAAGGC ATAAGAAAAC 1201 TAAGAAATAT GCACAATAGC AGTCGAAACA AGAAGCCACA GACCTAGGAT TTCATGATTT 1261 CATTTCAACT GTTTGCCTTC TGCTTTTAAG TTGCTGATGA ACTCTTAATC AAATAGCATA 1321 AGTTTCTGGG ACCTCAGTTT TATCATTTTC AAAATGGAGG GAATAATACC TAAGCCTTCC 1381 TGCCGCAACA GTTTTTTATG CTAATCAGGG AGGTCATTTT GGTAAAATAC TTCTCGAAGC 1441 CGAGCCTCAA GATGAAGGCA AAGCACGAAA TGTTATTTTT TAATTATTAT TTATATATGT 1501 ATTTATAAAT ATATTTAAGA TAATTATAAT ATACTATATT TATGGGAACC CCTTCATCCT 1561 CTGAGTGTGA CCAGGCATCC TCCACAATAG CAGACAGTGT TTTCTGGGAT AAGTAAGTTT 1621 GATTTCATTA ATACAGGGCA TTTTGGTCCA AGTTGTGCTT ATCCCATAGC CAGGAAACTC 1681 TGCATTCTAG TACTTGGGAG ACCTGTAATC ATATAATAAA TGTACATTAA TTACCTTGAG 1741 CCAGTAATTG GTCCGATCTT TGACTCTTTT GCCATTAAAC TTACCTGGGC ATTCTTGTTT 1801 CATTCAATTC CACCTGCAAT CAAGTCCTAC AAGCTAAAAT TAGATGAACT CAACTTTGAC 1861 AACCATGAGA CCACTGTTAT CAAAACTTTC TTTTCTGGAA TGTAATCAAT GTTTCTTCTA 1921 GGTTCTAAAA ATTGTGATCA GACCATAATG TTACATTATT ATCAACAATA GTGATTGATA 1981 GAGTGTTATC AGTCATAACT AAATAAAGCT TGCAACAAAA TTCTCTG (2) INFORMATION FOR SEQ ID NO:2518: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1308 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2518: 1 GCCACGTGCT GCTGGGTCTC AGTCCTCCAC TTCCCGTGTC CTCTGGAAGT TGTCAGGAGC 61 AATGTTGCGC TTGTACGTGT TGGTAATGGG AGTTTCTGCC TTCACCCTTC AGCCTGCGGC 121 ACACACAGGG GCTGCCAGAA GCTGCCGGTT TCGTGGGAGG CATTACAAGC GGGAGTTCAG 181 GCTGGAAGGG GAGCCTGTAG CCCTGAGGTG CCCCCAGGTG CCCTACTGGT TGTGGGCCTC 241 TGTCAGCCCC CGCATCAACC TGACATGGCA TAAAAATGAC TCTGCTAGGA CGGTCCCAGG 301 AGAAGAAGAG ACACGGATGT GGGCCCAGGA CGGTGCTCTG TGGCTTCTGC CAGCCTTGCA 361 GGAGGACTCT GGCACCTACG TCTGCACTAC TAGAAATGCT TCTTACTGTG ACAAAATGTC 421 CATTGAGCTC AGAGTTTTTG AGAATACAGA TGCTTTCCTG CCGTTCATCT CATACCCGCA WO 00/09525 PCT/US99/17712 EPI-109 685 481 AATTTTAACC TTGTCAACCT CTGGGGTATT AGTATGCCCT GACCTGAGTG AATTCACCCG 541 TGACAAAACT GACGTGAAGA TTCAATGGTA CAAGGATTCT CTTCTTTTGG ATAAAGACAA 601 TGAGAAATTT CTAAGTGTGA GGGGGACCAC TCACTTACTC GTACACGATG TGGCCCTGGA 661 AGATGCTGGC TATTACCGCT GTGTCCTGAC ATTTGCCCAT GAAGGCCAGC AATACAACAT 721 CACTAGGAGT ATTGAGCTAC GCATCAAGAA AAAAAAAGAA GAGACCATTC CTGTGATCAT 781 TTCCCCCCTC AAGACCATAT CAGCTTCTCT GGGGTCAAGA CTGACAATCC CGTGTAAGGT 841 GTTTCTGGGA ACCGGCACAC CCTTAACCAC CATGCTGTGG TGGACGGCCA ATGACACCCA 901 CATAGAGAGC GCCTACCCGG GAGGCCGCGT GACCGAGGGG CCACGCCAGG AATATTCAGA 961 AAATAATGAG AACTACATTG AAGTGCCATT GATTTTTGAT CCTGTCACAA GAGAGGATTT 1021 GCACATGGAT TTTAAATGTG TTGTCCATAA TACCCTGAGT TTTCAGACAC TACGCACCAC 1081 AGTCAAGGAA GCCTCCTCCA CGTTCTCCTG GGGCATTGTG CTGGCCCCAC TTTCACTGGC 1141 CTTCTTGGTT TTGGGGGGAA TATGGATGCA CAGACGGTGC AAACACAGAA CTGGAAAAGC 1201 AGATGGTCTG ACTGTGCTAT GGCCTCATCA TCAAGACTTT CAATCCTATC CCAAGTGAAA 1261 TAAATGGAAT GAAATAATTC AAACACAAAA AAAAAAAAAA AAAAAAAA (2) INFORMATION FOR SEQ ID NO:2519: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 2156 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2519: 1 GCCGGAGCCG ACTCGGAGCG CGCGGCGCGG CCGGGAGGAG CCGAGCGCGC CGGGCGCGGC 61 GTGGGGGCGC CGGCTGCCCC GCGCGCCCAG GGAGCGGCAG GAATGTGACA ATCGCGCGCC 121 CGCACCGTAG CACTCCTCGC TCGGCTCCTA GGGCTCTCGC CCTCTGAGCT GAGCCGGGTT 181 CCGCCCGGGC TGGGATCCCA TCACCCTCCA CGGCCGTCCG TCCAGGTAGA CGCACCCTCT 241 GAAGATGGTG ACTCCCTCCT GAGAAGCTGG ACCCCTTGGT AAAAGACAAG GCCTTCTCCA 301 AGAAGAATAT GAAAGTGTTA CTCAGACTTA TTTGTTTCAT AGCTCTACTG ATTTCTTCTC 361 TGGAGGCTGA TAAATGCAAG GAACGTGAAG AAAAAATAAT TTTAGTGTCA TCTGCAAATG 421 AAATTGATGT TCGTCCCTGT CCTCTTAACC CAAATGAACA CAAAGGCACT ATAACTTGGT 481 ATAAAGATGA CAGCAAGACA CCTGTATCTA CAGAACAAGC CTCCAGGATT CATCAACACA 541 AAGAGAAACT TTGGTTTGTT CCTGCTAAGG TGGAGGATTC AGGACATTAC TATTGCGTGG 601 TAAGAAATTC ATCTTACTGC CTCAGAATTA AAATAAGTGC AAAATTTGTG GAGAATGAGC 661 CTAACTTATG TTATAATGCA CAAGCCATAT TTAAGCAGAA ACTACCCGTT GCAGGAGACG 721 GAGGACTTGT GTGCCCTTAT ATGGAGTTTT TTAAAAATGA AAATAATGAG TTACCTAAAT 781 TACAGTGGTA TAAGGATTGC AAACCTCTAC TTCTTGACAA TATACACTTT AGTGGAGTCA 841 AAGATAGGCT CATCGTGATG AATGTGGCTG AAAAGCATAG AGGGAACTAT ACTTGTCATG 901 CATCCTACAC ATACTTGGGC AAGCAATATC CTATTACCCG GGTAATAGAA TTTATTACTC 961 TAGAGGAAAA CAAACCCACA AGGCCTGTGA TTGTGAGCCC AGCTAATGAG ACAATGGAAG 1021-TAGACTTGGG ATCCCAGATA CAATTGATCT GTAATGTCAC CGGCCAGTTG AGTGACATTG 1081 CTTACTGGAA GTGGAATGGG TCAGTAATTG ATGAAGATGA CCCAGTGCTA GGGGAAGACT 1141 ATTACAGTGT GGAAAATCCT GCAAACAAAA GAAGGAGTAC CCTCATCACA GTGCTTAATA 1201 TATCGGAAAT TGAAAGTAGA TTTTATAAAC ATCCATTTAC CTGTTTTGCC AAGAATACAC 1261 ATGGTATAGA TGCAGCATAT ATCCAGTTAA TATATCCAGT CACTAATTTC CAGAAGCACA 1321 TGATTGGTAT ATGTGTCACG TTGACAGTCA TAATTGTGTG TTCTGTTTTC ATCTATAAAA 1381 TCTTCAAGAT TGACATTGTG CTTTGGTACA GGGATTCCTG CTATGATTTT CTCCCAATAA 1441 AAGCTTCAGA TGGAAAGACC TATGACGCAT ATATACTGTA TCCAAAGACT GTTGGGGAAG 1501 GGTCTACCTC TGACTGTGAT ATTTTTGTGT TTAAAGTCTT GCCTGAGGTC TTGGAAAAAC 1561 AGTGTGGATA TAAGCTGTTC ATTTATGGAA GGGATGACTA CGTTGGGGAA GACATTGTTG 1621 AGGTCATTAA TGAAAACGTA AAGAAAAGCA GAAGACTGAT TATCATTTTA GTCAGAGAAA 1681 CATCAGGCTT CAGCTGGCTG GGTGGTTCAT CTGAAGAGCA AATAGCCATG TATAATGCTC 1741 TTGTTCAGGA TGGAATTAAA GTTGTCCTGC TTGAGCTGGA GAAAATCCAA GACTATGAGA 1801 AAATGCCAGA ATCGATTAAA TTCATTAAGC AGAAACATGG GGCTATCCGC TGGTCAGGGG 1861 ACTTTACACA GGGACCACAG TCTGCAAAGA CAAGGTTCTG GAAGAATGTC AGGTACCACA 1921 TGCCAGTCCA GCGACGGTCA CCTTCATCTA AACACCAGTT ACTGTCACCA GCCACTAAGG 1981 AGAAACTGCA AAGAGAGGCT CACGTGCCTC TCGGGTAGCA TGGAGAAGTT GCCAAGAGTT 2041 CTTTAGGTGC CTCCTGTCTT ATGGCGTTGC AGGCCAGGTT ATGCCTCATG CTGACTTGCA 2101 GAGTTCATGG AATGTAACTA TATCATCCTT TATCCCTGAG GTCACCAGGA ATCAGG (2) INFORMATION FOR SEQ ID NO:2520: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 3464 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2520: 1 GCCACGTGCT GCTGGGTCTC AGTCCTCCAC TTCCCGTGTC CTCTGGAAGT TGTCAGGAGC 61 AATGTTGCGC TTGTACGTGT TGGTAATGGG AGTTTCTGCC TTCACCCTTC AGCCTGCGGC 121 ACACACAGGG GCTGCCAGAA GCTGCCGGTT TCGTGGGAGG CATTACAAGC GGGAGTTCAG WO 00/09525 PCTIUS99/17712 EPI-109 686 181 GCTGGAAGGG GAGCCTGTAG CCCTGAGGTG CCCCCAGGTG CCCTACTGGT TGTGGGCCTC 241 TGTCAGCCCC CGCATCAACC TGACATGGCA TAAAAATGAC TCTGCTAGGA CGGTCCCAGG 301 AGAAGAAGAG ACACGGATGT GGGCCCAGGA CGGTGCTCTG TGGCTTCTGC CAGCCTTGCA 361 GGAGGACTCT GGCACCTACG TCTGCACTAC TAGAAATGCT TCTTACTGTG ACAAAATGTC 421 CATTGAGCTC AGAGTTTTTG AGAATACAGA TGCTTTCCTG CCGTTCATCT CATACCCGCA 481 AATTTTAACC TTGTCAACCT CTGGGGTATT AGTATGCCCT GACCTGAGTG AATTCACCCG 541 TGACAAAACT GACGTGAAGA TTCAATGGTA CAAGGATTCT CTTCTTTTGG ATAAAGACAA 601 TGAGAAATTT CTAAGTGTGA GGGGGACCAC TCACTTACTC GTACACGATG TGGCCCTGGA 661 AGATGCTGGC TATTACCGCT GTGTCCTGAC ATTTGCCCAT GAAGGCCAGC AATACAACAT 721 CACTAGGAGT ATTGAGCTAC GCATCAAGAA AAAAAAAGAA GAGACCATTC CTGTGATCAT 781 TTCCCCCCTC AAGACCATAT CAGCTTCTCT GGGGTCAAGA CTGACAATCC CGTGTAAGGT 841 GTTTCTGGGA ACCGGCACAC CCTTAACCAC CATGCTGTGG TGGACGGCCA ATGACACCCA 901 CATAGAGAGC GCCTACCCGG GAGGCCGCGT GACCGAGGGG CCACGCCAGG AATATTCAGA 961 AAATAATGAG AACTACATTG AAGTGCCATT GATTTTTGAT CCTGTCACAA GAGAGGATTT 1021 GCACATGGAT TTTAAATGTG TTGTCCATAA TACCCTGAGT TTTCAGACAC TACGCACCAC 1081 AGTCAAGGAA GCCTCCTCCA CGTTCTCCTG GGGCATTGTG CTGGCCCCAC TTTCACTGGC 1141 CTTCTTGGTT TTGGGGGGAA TATGGATGCA CAGACGGTGC AAACACAGAA CTGGAAAAGC 1201 AGATGGTCTG ACTGTGCTAT GGCCTCATCA TCAAGACTTT CAATCCTATC CCAAGTGAAA 1261 TAAATGGAAT GAAATAATTC AAACACAAAA AAAAAAAAAA AAAAAAAA 1 GCCGGAGCCG ACTCGGAGCG CGCGGCGCGG CCGGGAGGAG CCGAGCGCGC CGGGCGCGGC 61 GTGGGGGCGC CGGCTGCCCC GCGCGCCCAG GGAGCGGCAG GAATGTGACA ATCGCGCGCC 121 CGCACCGTAG CACTCCTCGC TCGGCTCCTA GGGCTCTCGC CCTCTGAGCT GAGCCGGGTT 181 CCGCCCGGGC TGGGATCCCA TCACCCTCCA CGGCCGTCCG TCCAGGTAGA CGCACCCTCT 241 GAAGATGGTG ACTCCCTCCT GAGAAGCTGG ACCCCTTGGT AAAAGACAAG GCCTTCTCCA 301 AGAAGAATAT GAAAGTGTTA CTCAGACTTA TTTGTTTCAT AGCTCTACTG ATTTCTTCTC 361 TGGAGGCTGA TAAATGCAAG GAACGTGAAG AAAAAATAAT TTTAGTGTCA TCTGCAAATG 421 AAATTGATGT TCGTCCCTGT CCTCTTAACC CAAATGAACA CAAAGGCACT ATAACTTGGT 481 ATAAAGATGA CAGCAAGACA CCTGTATCTA CAGAACAAGC CTCCAGGATT CATCAACACA 541 AAGAGAAACT TTGGTTTGTT CCTGCTAAGG TGGAGGATTC AGGACATTAC TATTGCGTGG 601 TAAGAAATTC ATCTTACTGC CTCAGAATTA AAATAAGTGC AAAATTTGTG GAGAATGAGC 661 CTAACTTATG TTATAATGCA CAAGCCATAT TTAAGCAGAA ACTACCCGTT GCAGGAGACG 721 GAGGACTTGT GTGCCCTTAT ATGGAGTTTT TTAAAAATGA AAATAATGAG TTACCTAAAT 781 TACAGTGGTA TAAGGATTGC AAACCTCTAC TTCTTGACAA TATACACTTT AGTGGAGTCA 841 AAGATAGGCT CATCGTGATG AATGTGGCTG AAAAGCATAG AGGGAACTAT ACTTGTCATG 901 CATCCTACAC ATACTTGGGC AAGCAATATC CTATTACCCG GGTAATAGAA TTTATTACTC 961 TAGAGGAAAA CAAACCCACA AGGCCTGTGA TTGTGAGCCC AGCTAATGAG ACAATGGAAG 1021 TAGACTTGGG ATCCCAGATA CAATTGATCT GTAATGTCAC CGGCCAGTTG AGTGACATTG 1081 CTTACTGGAA GTGGAATGGG TCAGTAATTG ATGAAGATGA CCCAGTGCTA GGGGAAGACT 1141 ATTACAGTGT GGAAAATCCT GCAAACAAAA GAAGGAGTAC CCTCATCACA GTGCTTAATA 1201 TATCGGAAAT TGAAAGTAGA TTTTATAAAC ATCCATTTAC CTGTTTTGCC AAGAATACAC 1261 ATGGTATAGA TGCAGCATAT ATCCAGTTAA TATATCCAGT CACTAATTTC CAGAAGCACA 1321 TGATTGGTAT ATGTGTCACG TTGACAGTCA TAATTGTGTG TTCTGTTTTC ATCTATAAAA 1381 TCTTCAAGAT TGACATTGTG CTTTGGTACA GGGATTCCTG CTATGATTTT CTCCCAATAA 1441 AAGCTTCAGA TGGAAAGACC TATGACGCAT ATATACTGTA TCCAAAGACT GTTGGGGAAG 1501 GGTCTACCTC TGACTGTGAT ATTTTTGTGT TTAAAGTCTT GCCTGAGGTC TTGGAAAAAC 1561 AGTGTGGATA TAAGCTGTTC ATTTATGGAA GGGATGACTA CGTTGGGGAA GACATTGTTG 1621 AGGTCATTAA TGAAAACGTA AAGAAAAGCA GAAGACTGAT TATCATTTTA GTCAGAGAAA 1681 CATCAGGCTT CAGCTGGCTG GGTGGTTCAT CTGAAGAGCA AATAGCCATG TATAATGCTC 1741 TTGTTCAGGA TGGAATTAAA GTTGTCCTGC TTGAGCTGGA GAAAATCCAA GACTATGAGA 1801 AAATGCCAGA ATCGATTAAA TTCATTAAGC AGAAACATGG GGCTATCCGC TGGTCAGGGG 1861 ACTTTACACA GGGACCACAG TCTGCAAAGA CAAGGTTCTG GAAGAATGTC AGGTACCACA 1921 TGCCAGTCCA GCGACGGTCA CCTTCATCTA AACACCAGTT ACTGTCACCA GCCACTAAGG 1981 AGAAACTGCA AAGAGAGGCT CACGTGCCTC TCGGGTAGCA TGGAGAAGTT GCCAAGAGTT 2041 CTTTAGGTGC CTCCTGTCTT ATGGCGTTGC AGGCCAGGTT ATGCCTCATG CTGACTTGCA 2101 GAGTTCATGG AATGTAACTA TATCATCCTT TATCCCTGAG GTCACCAGGA ATCAGG (2) INFORMATION FOR SEQ ID NO:2521: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1185 base pairs .(B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2521: 1 GCTCAGGGCA CATGCCTCCC CTCCCCAGGC CGCGGCCCAG CTGACCCTCG GGGCTCCCCC 61 GGCAGCGGAC AGGGAAGGGT TAAAGGCCCC CGGCTCCCTG CCCCCTGCCC TGGGGAACCC 121 CTGGCCCTGT GGGGACATGA ACTGTGTTTG CCGCCTGGTC CTGGTCGTGC TGAGCCTGTG 181 GCCAGATACA GCTGTCGCCC CTGGGCCACC ACCTGGCCCC CCTCGAGTTT CCCCAGACCC 241 TCGGGCCGAG CTGGACAGCA CCGTGCTCCT GACCCGCTCT CTCCTGGCGG ACACGCGGCA 301 GCTGGCTGCA CAGCTGAGGG ACAAATTCCC AGCTGACGGG GACCACAACC TGGATTCCCT WO 00/09525 PCT/US99/17712 EPI-109 687 361 GCCCACCCTG GCCATGAGTG CGGGGGCACT GGGAGCTCTA CAGCTCCCAG GTGTGCTGAC 421 AAGGCTGCGA GCGGACCTAC TGTCCTACCT GCGGCACGTG CAGTGGCTGC GCCGGGCAGG 481 TGGCTCTTCC CTGAAGACCC TGGAGCCCGA GCTGGGCACC CTGCAGGCCC GACTGGACCG 541 GCTGCTGCGC CGGCTGCAGC TCCTGATGTC CCGCCTGGCC CTGCCCCAGC CACCCCCGGA 601 CCCGCCGGCG CCCCCGCTGG CGCCCCCCTC CTCAGCCTGG GGGGGCATCA GGGCCGCCCA 661 CGCCATCCTG GGGGGGCTGC ACCTGACACT TGACTGGGCC GTGAGGGGAC TGCTGCTGCT 721 GAAGACTCGG CTGTGACCCG GGGCCCAAAG CCACCACCGT CCTTCCAAAG CCAGATCTTA 781 TTTATTTATT TATTTCAGTA CTGGGGGCGA AACAGCCAGG TGATCCCCCC GCCATTATCT 841 CCCCCTAGTT AGAGACAGTC CTTCCGTGAG GCCTGGGGGA CATCTGTGCC TTATTTATAC 901 TTATTTATTT CAGGAGCAGG GGTGGGAGGC AGGTGGACTC CTGGGTCCCC GAGGAGGAGG 961 GGACTGGGGT CCCGGATTCT TGGGTCTCCA AGAAGTCTGT CCACAGACTT CTGCCCTGGC 1021 TCTTCCCCAT CTAGGCCTGG GCAGGAACAT ATATTATTTA TTTAAGCAAT TACTTTTCAT 1081 GTTGGGGTGG GGACGGAGGG GAAAGGGAAG CCTGGGTTTT TGTACAAAAA TGTGAGAAAC 1141 CTTTGTGAGA CAGAGAACAG GGAATTAAAT GTGTCATACA TATCC (2) INFORMATION FOR SEQ ID NO:2522: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 6870 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2522: 1 CAGCTGCGGC ATCCTCTGTC TCAGAGTCTT GGTGTCTCTG TTCCTTTCCC CTCGGGGTCT 61 CCCTGGGTCT CCCCAAGTCC CTCCTGCTGT CTTCCTCCCG CTCTCTGATC TCTGACTCCC 121 AGAACCTCTC CCTCTGTCTC CAGGGCTGCC CCTCTGATCC TCTTTGCTTC TCTGGTGTGT 181 CTCTCTGGCT GCCTCCATCT CTGTGGATCT CCGTCTCCCT GTCTCTGTCT CAGTCTGTCC 241 TTCACTCTGT GTGTGTGTGT GTCTCTCTCT CTCTCTCTCC TTCCCTTCCA CTCCCTCTTC 301 CTCCTGCCTC CACCTCTCCA GGCCCCTGTC TTGTCCCTCC GTCCGGCCTT TCTCTGCCTT 361 TCCGTCCTCC TGCCTCCCCA TCTCTCTCTG CTAGTCCTGT CCAGCCGGAC CCCCACCCAC 421 AGTCGGGCCC CAGCGCTTGA GCCTGAGTGT CTGCTCCGGC CCGTGGAGGT GGAGGGAGGG 481 GACGCCAATG ACCTCACCAG CCCCTCTCCG ACCACCCCCC CCTTTCCCTT TTCAACTTTT 541 CCAACTTTTC CTTCCGTGCC CTCCTCCGAG CGCGGCGGCG TGAGCCCTGC AAGGCAGCCG 601 CTCCGTCTGA ATGGAAAAGG CAGGCAGGGA GGGTGAGTCA GGATGTGTCA GGCCGGCCCT 661 CCCCTGCCGC CTGCCCCCCG CCCGCCCGCC CCAGGCCCCC TATATAACCC CCCAGGCGTC 721 CACACTCCCT CACTGCCGCG GGCCCTGCTG CTCAGGGCAC ATGCCTCCCC TCCCCAGCCG 781 CGGGCCCAGC TGACCCTCGG GGCTCCCCCG GCAGCGGACA GGGAAGGGTT AAAGGCCCCC 841 GGCTCCCTGC CCCCTGCCCT GGGGAACCCC TGGCCCTGTG GGGACATGAA CTGTAAGTTG 901 GTTCATGGGG AGGGTGGAGG GGACAGGGAG GCAGGGAGGA GAGGGACCCA CGGCGGGGGT 961 GGGAGCAGAC CCCGCTGAGT CGCACAGAGA GGGACCCGGA GACAGGCAGC CGGGGAGGAG 1021 AGCAGCTTCG GAGACAGGAG GCGGCGGAGG AGATGGGCAG AGAGAGACAC AGACAGGAGC 1081 GGATGGAGGC AGCCAATCAG AGGCGCCGCA GGAGGGACGG GCCAGACAGG GCCCGAGAGG 1141 AGCGAGACGC GAGACCGAGC AGGGGCAGGG ACGCAGGGAC TGGTGCCGGG AGGGAGGTGA 1201 CCCCCATCGA CCCAGGCCCC AGGGAGCCCG CGGGGACCGG GAGACTCCCT GGGATTCCGG 1261 CAGAGAGGCT CCGGAGGGAA ACTGAGGCAG GGTCCGCGGA GAGCGGAGCA AGCCAGGGAG 1321 TAGCGACCCC AGCCGGGGGG AGGAGAGAGA CTGGGCGCCG GGGGAAAGCG GGGAGAGCCG 1381 GGCAGATGCG GCCGACGGAG GCGCGGACAG ACCGACGGCT GGCGGGCCCG GGGGGCGGGC 1441 TGGGGGTGTG CGAGGCGCGG GCGGCCGGGG AGCGCTGATT GGCTGGCGGG TGGCCGGGTG 1501 GGCGGGGCGG CCGGGGTGGG CTGCGGGGAG CGAGCTCCGG ACCCCCGCGC CCCCGGCGCC 1561 CCCCGCGCCC CCCGCCGCCA GCTCTCCCGC TCCCGGCGCC CGGCCGGGCC ATGGCTCTGC 1621 CCCTCTCCGC CCAGGTGCGC TGCGGCCCGG GCTTCTGCCG CCCACCCGGC GGGCTCCTGG 1681 GAGGGCGTCT AAGGGGTCTC CCGTGGGAGA GGTCCGTGTC TCCCGGACTC CGTCCTGGGC 1741 TTTTGGCTCC TTCCCCTGCT CCCAGCCAGC TCGGGCTCCC GCGGCCCGGG GAGGGGGCAG 1801 GTTCTGGCCT GTGCCTCCCC CACCATCCGC GCCCCGGGGC CCAGATTCCG GCGTCCGGGG 1861 GCGGACGGGA GACGCCCGGG CCGCGTCTGC TCCGACGGGC GGGGCAGCCA GAGCCAGGGA 1921 GGGAGAGGGA AGCCCGCCTG GCCCTGCGAC CTGCCCGCGG GCGTTCCACC CTGGGACTTA 1981 AGACCTCCAG CTCCATCCTC CCTAAGGCCG GGAGTCCAGG CCCCAGACCC TCCTCCCCGA 2041 GACCCAGGAG TCCAGACCCC AGGCCTTCCT CCCTCAGACC TAGGAGTCCA GGCCCCCAGC 2101 CTCTCCTCCC TCAGACCCAG GAGGAGTCCA GACCCCAGTT CCTCCTCCCT CAGACCCGGG 2161 AGTCCAGCCC AGGCCCTCCT CTCTCAGACC CGGAGTCCAG CCTGAGCTCT CTGCCTTATC 2221 CTGCCCCCAG GTGTTTGCCG CCTGGTCCTG GTCGTGCTGA GCCTGTGGCC AGATACAGCT 2281 GTCGCCCCTG GGCCACCACC TGGCCCCCCT CGAGTTTCCC CAGACCCTCG GGCCGAGCTG 2341 GACAGCACCG TGCTCCTGAC CCGCTCTCTC CTGGCGGACA CGCGGCAGCT GGCTGCACAG 2401 CTGGTAGGAG AGACTGGGCT GGGGCCAGCA CAGGAGTGAG AGGCAGAGAG GAACGGAGAG 2461 GAGTCTGCGG GCAGCCACTT GGAGGGGTTC TGGGCTCTCA GGTGGCAGAG TGAGGGAGGG 2521 GAAGAGTTGG GGGCCTGGCG TGGGGGATGG AGGGAGCCCC GAGGCTGGGC AGGGGCCACC 2581 TCACAGCTTT TTTCCCTGCC AGAGGGACAA ATTCCCAGCT GACGGGGACC ACAACCTGGA 2641 TTCCCTGCCC ACCCTGGCCA TGAGTGCAGG GGCACTGGGA GCTCTACAGG TAAGGGCAAG 2701 GGAGTGGGCT GGGGACAAGG TGGGAGGCAG GCAGTGAAGG GGGCGGGGAG GATGAGGGGC 2761 ACTGGTCGGG TGTTCTCTGA TGTCCCGGCT CTATCCCCAG CTCCCAGGTG TGCTGACAAG WO 00/09525 PCTIUS99/17712 EPI-109 688 2821 GCTGCGAGCG GACCTACTGT CCTACCTGCG GCACGTGCAG TGGCTGCGCC GGGCAGGTGG 2881 CTCTTCCCTG AAGACCCTGG AGCCCGAGCT GGGCACCCTG CAGGCCCGAC TGGACCGGCT 2941 GCTGCGCCGG CTGCAGCTCC TGGTATGTCC TGGCCCCAAG ACCTGACACC CCAGACCCCC 3001 ACCCCTGGOC CCAAAATCCT GTGGCCTGAG TCCTTGAAGC CTGAGACCCC AGACCCGAGT 3061 GCAACAGCCC CGCTCTGAGA CCCTGACACC CTAACAGCCC GCTCTGAGAC CCTGACACCG 3121 TAACAGCCCC GCTCTGAGAC CCTGACCCTA ACAGTCCTGC TCTGAGACCC TGACCCTGCA 3181 GTCCCAAGAT CCTGTGGCCC TGAGACCCTG AGGCCCTAGA CCCCCAAATC CTGCCCAGAA 3241 ACTTCAAATT CTCACCCAAG ACCCTGAGAC TCCATCATCC ATGACCTCAA AGTCCCCAGA 3301 TCCCAGCCCC TAAGACCCAA GACCCCATCC TGAAGCCCAA AGCCTTGAGA ATTCAAATCC 3361 TCACCTCAAG ACTTGGAGAC CCTGGCCCCA TGACATTGAA AACCATGGAC CTGGCCAGGC 3421 GTGGTGGCTC ACGCCTGTAA TCCCAGCACT TTGGGAGGCC CAGGCAAGTG GATCACCTGA 3481 GGTCGGGAGT TCAAGACCAC CCAGACCAAC ATGGTGAAAC CCTGTCTCTA CTAAAAATAC 3541 AAAATTAGCC AGGCGTGGTG GTGCATGCCT GTAATCCCAG CTACTTGGGA GGCTGAGGCA 3601 GGAGAATCGC TTGAACCTGG GAGGCGGAGG TTGCAGTGAG CCGAGATCGC ACCATTACAC 3661 TCCAGCCTGG GCAACAAGAG CAAAACTCCC TCTCTCTCAA AAAAAAAAAA AAAAAAAAA 3721 AAGAAGGAAA AGAAAACCAT GGACCTCCAG ACCCTGAGAC CCCAGGCCCC AGCCCTGAGA 3781 TCCTGACATC TTAAAGATCC CAGGCCCTAA GATACAAGAC CTTGACCCAA AGCCAGCCTT 3841 GGGACCCTGG CTGTACAAAC CCAAGACCTC CAGGACCTAG ACCCCGAGCC CTGAGGCCCT 3901 ATGTCTCACT CCCAACATCG AAAACCCTGA CACCTCAGAT CCTGAGCCTG CGCCTGTACG 3961 ACTCCAAGAC CCTCACTTCC AAAGCCAGGC CCAAAGCCCT GAGACCAGAA GACTTCAAAC 4021 CCTGGTTCTT GGGCCTAACT CCAAAGACCC TGGATCTCAA ATTCCAACTT CTAGCTCTGA 4081 GACTCCAGCC CTCACCCATG AGTTCCTGAA CTTGAACCCA GAGACCCCAT CTCTAAGACT 4141 TCAGCCTTGA GATCCAGGGC CTGACCCTAG ACTCGAGCCC ACAGACCTCA GATACTGTCT 4201 GCTAAAACCCC AGCCTCTGGTG GGGACCAGTG GCTCACTCCT GTAATCCCAA GGCAGGGGAG 4261 GCCAAGGCAG AAGGACCTCT TAGGCCATGC AGTTTGAGAC AGCCTCGGCA GCATAGCAAG 4321 ACTCTGTTTC TTAATTATTA TTATTATTAT TATTTTTTCG AGACAGAGTC TCGCGCTCTG 4381 TTGCCCAGCC TAGAGTGCAA TGGTGCCATT TCGGCTTGC CTGAACCTCCG CCTCCTGGGC 4441 TCAAGCGATT CTCCTGCCTC AGCCTCCTCA GTAGCTGGGA CTTCAGGTGC ACACTGCCAC 4501 ACCCCGATAA TTTTTTTGTA TTTTAGTAGA CACAGGGTTT CACCGTGTTGC CCCACGCTG 4561 TCACAAACTC CTGAGCTCAG GCCATCCGCC CGCCTCGGCC TCCCAAAGCG CTGGGATAAC 4621 AGGCGTGACG CCGCGCCTGG CTTCTTAATT GTTCTAACAG CAGCGACAAC AACAAAAACC 4681 CAGCTCTGAG ATTCCAGCCC CGGCGACTCT AACAGTCCCA GCCCGATCC CTCACCTAGA 4741 ACCGAGATGC CAGCCCTGAC TCCACAGACT TCACCCCCAA CCCCCACACT CAGCTCTGGA 4801 AGCCCGTCCT GACTCCAGCC TCCATTTTCG GAACCCCACA GCCTGAAGAG CTCCCGGCCT 4861 AAACACTTCA CCCCACGCGC CACAGTCCCC CTGTGAATAT GCAGCCCCGA TTCAGCTGCA 4921 GCTCCACAGC ACCCCTGCCC TGCACCCCCT CTGCACCCCC TACCTGTGAC TCACCTCTCT 4981 CCTCTCCCCA CAGATGTCCC GCCTGGCCCT GCCCCAGCCA CCCCCGGACC CGCCGGCGCC 5041 CCCGCTGGCG CCCCCCTCCT CAGCCTGGGG GGGCATCAGG GCCGCCCACG CCATCCTGGG 5101 GGGGCTGCAC CTGACACTTG ACTGGGCCGT GAGGGGACTG CTGCTGCTGA AGACTCGGCT 5161 GTGACCCGGG GCCCAAAGCC ACCACCGTCC TTCCAAAGCC AGATCTTATT TATTTATTTA 5221 TTTCAGTACT GGGGCGAAA CAGCCACGTG ATCCCCCCGC CATTATCTCC CCCTAGTTAG 5281 AGACAGTCCT TCCGTGAGGC CTGGGGGGCA TCTGTGCCTT ATTTATACTT ATTTATTTCA 5341 GAGCAGGGG TGGGAGGCAG GTGGACTCCT GGGTCCCCGA GGAGAGGGC ACTGGGGTCC 5401 CGGATTCTTG GGTCTCCAAG AAGTCTGTCC ACAGACTTCT GCCCTGGCTC TTCCCCATCT 5461 AGGCCTCCGC AGGAACATAT ATTATTTATT TAAGCAATTA CTTTTCATGT TGGGGTGGGG 5521 ACGGAGGGGA AAGGGAACCC TGGGTTTTTG TACAAAAATG TGAGAAACCT TTGTGAGACA 5581 GAGAACAGCG AATTAAATGT GTCATACATA TCCACTTGAG GCGATTTGT CTGAGAGCTG 5641 GGGCTGGATG CTTGGGTAAC TGGGGCAGGG CACGTGGAGG GGAGACCTCC ATTCAGGTGG 5701 AGGTCCCGAG TGGGCGGGGC AGCGACTGG AGATGGGTCG GTCACCCAGA CAGCTCTGTG 5761 GAGGCAGGGT CTGAGCCTTG CCTGGGGCCC CGCACTGCAT AGGGCCGTTT GTTTGTTTTT 5821 TGAGATGGAG TCTCGCTCTG TTGCCTAGGC TGGAGTGCAG TGAGGCAATC TAAGGTCACT 5881 GCAACCTCCA CCTCCCGGGT TCAAGCAATT CTCCTGCCTC AGCCTCCCGA TTAGCTGGGA 5941 TCACAGGTGT GCACCACCAT GCCCAGCTAA TTATTTATTT CTTTTGTATT TTTAGTAGAG 6001 ACAGGGTTTC ACCATGTTGG CCAGGCTGGT TTCGAACTCC TGACCTCAGG TGATCCTCCT 6061 GCCTCGGCCT CCCAAAGTGC TGGGATTACA GGTGTGAGCC ACCACACCTG ACCCATAGGT 6121 CTTCAATAAA TATTTAATGG AGGTTCCAC AAGTCACCCT GTGATCAACA GTACCCGTAT 6181 GGGACAAAGC TGCAAGGTCA AGATGGTTCA TTATGGCTGT GTTCACCATA GCAAACTGGA 6241 AACAATCTAG ATATCCAACA GTGAGGGTTA AGCAACATGG TGCATCTGTG GATAGAACGC 6301 CACCCAGCCG CCCGGAGCAG GGACTGTCAT TCAGGGAGC TAAGGAGAGA GGCTTGCTTG 6361 GCATATAGAA AGATATCCTG ACATTGCCA GGCATGGTGG CTCACGCCTG TAATCCTGGC 6421 ACTTTGGGAG GACGAAGCGA GTGGATCACT GAAGTCCAAG AGTTTGAGAC CGGCCTGCGA 6481 GACATGGCAA AACCCTGTCT CAAAAAAGAA AGAATGATGT CCTGACATGA AACAGCAGGC 6541 TACAAAACCA CTGCATGCTG TGATCCCAAT TTTGTGTTTT TCTTTCTATA TATGGATTAA 6601 AACAAAAATC CTAAAGGCAA ATACGCCAAA ATGTTGACAA TGACTGTCTC CAGGTCAAAG 6661 GAGAGAGGTG GGATTGTGGG TGACTTTTAA TGTGTATGAT TGTCTGTATT TTACAGAATT 6721 TCTGCCATGA CTGTGTATTT TGCATGACAC ATTTTAAAAA TAATAAACAC TATTTTTAGA 6781 ATAACAGAAT ATCAGCCTCC TCCTCTCCAA AAATAAGCCC TCAGGACGGG ACAAAGTTGA 6841 CCGCTGATTG ACCCTGTCAG CGCTGTGCAC WO 00/09525 PCT/US99/17712 EPI-109 689 (2) INFORMATION FOR SEQ ID NO:2523: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 8055 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2523: 1 GCTCAGGGCA CATGCCTCCC CTCCCCAGGC CGCGGCCCAG CTGACCCTCG GGGCTCCCCC 61 GGCAGCGGAC AGGGAAGGGT TAAAGGCCCC CGGCTCCCTG CCCCCTCCCC TGGGGAACCC 121 CTGGCCCTGT GGGGACATGA ACTGTGTTTG CCGCCTGGTC CTGGTCGTGC TGAGCCTGTG 181 GCCAGATACA GCTGTCGCCC CTGGGCCACC ACCTGGCCCC CCTCGAGTTT CCCCAGACCC 241 TCGGGCCGAG CTGGACAGCA CCGTGCTCCT GACCCGCTCT CTCCTGGCGG ACACGCGGCA 301 GCTGGCTGCA CAGCTGAGGG ACAAATTCCC AGCTGACGGG GACCACAACC TGGATTCCCT 361 GCCCACCCTG GCCATGAGTG CGGGGGCACT GGGAGCTCTA CAGCTCCCAG GTGTGCTGAC 421 AAGGCTGCGA GCGGACCTAC TGTCCTACCT GCGGCACGTG CAGTGGCTGC GCCGGGCAGG 481 TGGCTCTTCC CTGAAGACCC TGGAGCCCGA GCTGGGCACC CTGCAGGCCC GACTGGACCG 541 GCTGCTGCGC CGGCTGCAGC TCCTGATGTC CCGCCTGGCC CTGCCCCAGC CACCCCCGGA 601 CCCGCCGGCG CCCCCGCTGG CGCCCCCCTC CTCAGCCTGG GGGGGCATCA GGGCCGCCCA 661 CGCCATCCTG GGGGGGCTGC ACCTGACACT TGACTGGGCC GTGAGGGGAC TGCTGCTGCT 721 GAAGACTCGG CTGTGACCCG GGGCCCAAAG CCACCACCGT CCTTCCAAAG CCAGATCTTA 781 TTTATTTATT TATTTCAGTA CTGGGGGCGA AACAGCCAGG TGATCCCCCC GCCATTATCT 841 CCCCCTAGTT AGAGACAGTC CTTCCGTGAG GCCTGGGGGA CATCTGTGCC TTATTTATAC 901 TTATTTATTT CAGGAGCAGG GGTGGGAGGC AGGTGGACTC CTGGGTCCCC GAGGAGGAGG 961 GGACTGGGGT CCCGGATTCT TGGGTCTCCA AGAAGTCTGT CCACAGACTT CTGCCCTGGC 1021 TCTTCCCCAT CTAGGCCTGG GCAGGAACAT ATATTATTTA TTTAAGCAAT TACTTTTCAT 1081 GTTGGGGTGG GGACGGAGGG GAAAGGGAAG CCTGGGTTTT TGTACAAAAA TGTGAGAAAC 1141 CTTTGTGAGA CAGAGAACAG GGAATTAAAT GTGTCATACA TATCC 1 CAGCTGCGGC ATCCTCTGTC TCAGAGTCTT GGTGTCTCTG TTCCTTTCCC CTCGGGGTCT 61 CCCTGGGTCT CCCCAAGTCC CTCCTGCTGT CTTCCTCCCG CTCTCTGATC TCTGACTCCC 121 AGAACCTCTC CCTCTGTCTC CAGGGCTGCC CCTCTGATCC TCTTTGCTTC TCTGGTGTGT 181 CTCTCTGGCT GCCTCCATCT CTGTGGATCT CCGTCTCCCT GTCTCTGTCT CAGTCTGTCC 241 TTCACTCTGT GTGTGTGTGT GTCTCTCTCT CTCTCTCTCC TTCCCTTCCA CTCCCTCTTC 301 CTCCTGCCTC CACCTCTCCA GGCCCCTGTC TTGTCCCTCC GTCCGGCCTT TCTCTGCCTT 361 TCCGTCCTCC TGCCTCCCCA TCTCTCTCTG CTAGTCCTGT CCAGCCGGAC CCCCACCCAC 421 AGTCGGGCCC CAGCGCTTGA GCCTGAGTGT CTGCTCCGGC CCGTGGAGGT GGAGGGAGGG 481 GACGCCAATG ACCTCACCAG CCCCTCTCCG ACCACCCCCC CCTTTCCCTT TTCAACTTTT 541 CCAACTTTTC CTTCCGTGCC CTCCTCCGAG CGCGGCGGCG TGAGCCCTGC AAGGCAGCCG 601 CTCCGTCTGA ATGGAAAAGG CAGGCAGGGA GGGTGAGTCA GGATGTGTCA GGCCGGCCCT 661 CCCCTGCCGC CTGCCCCCCG CCCGCCCGCC CCAGGCCCCC TATATAACCC CCCAGGCGTC 721 CACACTCCCT CACTGCCGCG GGCCCTGCTG CTCAGGGCAC ATGCCTCCCC TCCCCAGCCG 781 CGGGCCCAGC TGACCCTCGG GGCTCCCCCG GCAGCGGACA GGGAAGGGTT AAAGGCCCCC 841 GGCTCCCTGC CCCCTGCCCT GGGGAACCCC TGGCCCTGTG GGGACATGAA CTGTAAGTTG 901 GTTCATGGGG AGGGTGGAGG GGACAGGGAG GCAGGGAGGA GAGGGACCCA CGGCGGGGGT 961 GGGAGCAGAC CCCGCTGAGT CGCACAGAGA GGGACCCGGA GACAGGCAGC CGGGGAGGAG 1021 AGCAGCTTCG GAGACAGGAG GCGGCGGAGG AGATGGGCAG AGAGAGACAC AGACAGGAGC 1081 GGATGGAGGC AGCCAATCAG AGGCGCCGCA GGAGGGACGG GCCAGACAGG GCCCGAGAGG 1141 AGCGAGACGC GAGACCGAGC AGGGGCAGGG ACGCAGGGAC TGGTGCCGGG AGGGAGGTGA 1201 CCCCCATCGA CCCAGGCCCC AGGGAGCCCG CGGGGACCGG GAGACTCCCT GGGATTCCGG 1261 CAGAGAGGCT CCGGAGGGAA ACTGAGGCAG GGTCCGCGGA GAGCGGAGCA AGCCAGGGAG 1321 TAGCGACCCC AGCCGGGGGG AGGAGAGAGA CTGGGCGCCG GGGGAAAGCG GGGAGAGCCG 1381 GGCAGATGCG GCCGACGGAG GCGCGGACAG ACCGACGGCT GGCGGGCCCG GGGGGCGGGC 1441 TGGGGGTGTG CGAGGCGCGG GCGGCCGGGG AGCGCTGATT GGCTGGCGGG TGGCCGGGTG 1501 GGCGGGGCGG CCGGGGTGGG CTGCGGGGAG CGAGCTCCGG ACCCCCGCGC CCCCGGCGCC 1561 CCCCGCGCCC CCCGCCGCCA GCTCTCCCGC TCCCGGCGCC CGGCCCGGCC ATGGCTCTGC 1621 CCCTCTCCGC CCAGGTGCGC TGCGGCCCGG GCTTCTGCCG CCCACCCGGC GGGCTCCTGG 1681 GAGGGCGTCT AAGGGGTCTC CCGTGGGAGA GGTCCGTGTC TCCCGGACTC CGTCCTGGGC 1741 TTTTGGCTCC TTCCCCTGCT CCCAGCCAGC TCGGGCTCCC GCGGCCCGGG GAGGGGGCAG 1801 GTTCTGGCCT GTGCCTCCCC CACCATCCGC GCCCCGGGGC CCAGATTCCG GCGTCCGGGG 1861 GCGGACGGGA GACGCCCGGG CCGCGTCTGC TCCGACGGGC GGGGCAGCCA GAGCCAGGGA 1921 GGGAGAGGGA AGCCCGCCTG GCCCTGCGAC CTGCCCGCGG GCGTTCCACC CTGGGACTTA 1981 AGACCTCCAG CTCCATCCTC CCTAAGGCCG GGAGTCCAGG CCCCAGACCC TCCTCCCCGA 2041 GACCCAGGAG TCCAGACCCC AGGCCTTCCT CCCTCAGACC TAGGAGTCCA GGCCCCCAGC 2101 CTCTCCTCCC TCAGACCCAG GAGGAGTCCA GACCCCAGTT CCTCCTCCCT CAGACCCGGG 2161 AGTCCAGCCC AGGCCCTCCT CTCTCAGACC CGGAGTCCAG CCTGAGCTCT CTGCCTTATC 2221 CTGCCCCCAG GTGTTTGCCG CCTGGTCCTG GTCGTGCTGA GCCTGTGGCC AGATACAGCT 2281 GTCGCCCCTG GGCCACCACC TGGCCCCCCT CGAGTTTCCC CAGACCCTCG GGCCGAGCTG 2341 GACAGCACCG TGCTCCTGAC CCGCTCTCTC CTGGCGGACA CGCGGCAGCT GGCTGCACAG 2401 CTGGTAGGAG AGACTGGGCT GGGGCCAGCA CAGGAGTGAG AGGCAGAGAG GAACGGAGAG WO 00/09525 PCT/US99/17712 EPI-109 690 2461 GAGTCTGCGG GCAGCCACTT GGAGGGGTTC TGGGCTCTCA GGTGGCAGAG TGAGGGAGGG 2521 GAAGAGTTGG GGGCCTGGCG TGGGCGATGG AGGGAGCCCC CAGGCTGGGC AGGGGCCACC 2581 TCACAGCTTT TTTCCCTGCC AGAGGGACAA ATTCCCAGCT GACGGGGACC ACAACCTGGA 2641 TTCCCTGCCC ACCCTGGCCA TGAGTGCAGG GGCACTGGGA GCTCTACAGG TAAGGGCAAG 2701 GGAGTGGGCT GGGGACAAGG TGGGAGGCAG GCAGTGAAGG GGGCGGGGAG GATGAGGGGC 2761 ACTGGTCGGG TGTTCTCTGA TGTCCCGGCT CTATCCCCAG CTCCCAGGTG TGCTGACAAG 2821 GCTGCGAGCG GACCTACTGT CCTACCTGCG GCACGTGCAG TGGCTGCGCC GGGCAGGTGG 2881 CTCTTCCCTG AAGACCCTGG AGCCCGAGCT GGGCACCCTG CAGGCCCGAC TGGACCGGCT 2941 GCTCCCCGG CTGCAGCTCC TGGTATGTCC TGGCCCCAAG ACCTGACACC CCAGACCCCC 3001 ACCCCTGGCC CCAAAATCCT GTGGCCTGAG TCCTTGAAGC CTGAGACCCC AGACCCGAGT 3061 GCAACAGCCC CGCTCTGAGA CCCTGACACC CTAACAGCCC GCTCTGAGAC CCTGACACCG 3121 TAACAGCCCC GCTCTGAGAC CCTGACCCTA ACAGTCCTGC TCTGAGACCC TGACCCTGCA 3181 GTCCCAAGAT CCTGTGGCCC TGAGACCCTG AGGCCCTAGA CCCCCAAATC CTGCCCAGAA 3241 ACTTCAAATT CTCACCCAAG ACCCTGAGAC TCCATCATCC ATGACCTCAA AGTCCCCAGA 3301 TCCCAGCCCC TAAGACCCAA GACCCCATCC TGAAGCCCAA AGCCTTGAGA ATTCAAATCC 3361 TCACCTCAAG ACTTGGAGAC CCTGGCCCCA TGACATTGAA AACCATGGAC CTGGCCAGGC 3421 GTGGTGGCTC ACGCCTGTAA TCCCAGCACT TTGGGAGGCC GAGGCAAGTG GATCACCTGA 3481 GGTCGGGAGT TCAAGACCAG CCAGACCAAC ATGGTGAAAC CCTGTCTCTA CTAAAAATAC 3541 AAAATTAGCC AGGCGTGGTG GTGCATGCCT GTAATCCCAG CTACTTGGGA GGCTGAGGCA 3601 GGAGAATCGC TTGAACCTGG GAGGCGGAGG TTGCAGTGAG CCGAGATCGC ACCATTACAC 3661 TCCAGCCTGG GCAACAAGAG CAAAACTCCC TCTCTCTCAA AAAAAAAAAA AAAAAAAAAA 3721 AAGAAGGAAA AGAAAACCAT GGACCTCCAG ACCCTGAGAC CCCAGGCCCC AGCCCTGAGA 3781 TCCTGACATC TTAAAGATCC CAGGCCCTAA GATACAAGAC CTTGACCCAA AGCCAGCCTT 3841 GGGACCCTGG CTGTACAAAC CCAAGACCTC CAGGACCTAG ACCCCGAGCC CTGAGGCCCT 3901 ATCTCTCACT CCCAACATCG AAAACCCTGA CACCTCAGAT CCTGAGCCTG CGCCTGTACG 3961 ACTCCAAGAC CCTCACTTCC AAAGCCAGGC CCAAAGCCCT GAGACCAGAA GACTTCAAAC 4021 CCTGGTTCTT GGGCCTAACT CCAAAGACCC TGGATCTCAA ATTCCAACTT CTAGCTCTGA 4081 GACTCCAGCC CTCACCCATG AGTTCCTGAA CTTGAACCCA GAGACCCCAT CTCTAAGACT 4141 TCAGCCTTGA GATCCAGGGC CTGACCCTAG ACTCGAGCCC ACAGACCTCA GATACTGTCT 4201 GTAAAACCCC AGCTCTGGTG GGGAGCAGTG GCTCACTCCT GTAATCCCAA GGCAGGGGAG 4261 GCCAAGGCAG AAGGACCTCT TGAGGCCATG AGTTTGAGAC AGCCTGGGCA GCATAGCAAG 4321 ACTCTGTTTC TTAATTATTA TTATTATTAT TATTTTTTGG AGACAGAGTC TCGCGCTCTG 4381 TTGCCCAGGC TAGAGTGCAA TGGTGCCATT TCGGCTTGCT GGAACCTCCG CCTCCTGGGC 4441 TCAAGCGATT CTCCTGCCTC AGCCTCCTGA GTAGCTGGGA CTTCAGGTGC ACACTGCCAC 4501 ACCCGGATAA TTTTTTTGTA TTTTAGTAGA CACAGGGTTT CACCGTGTTG CCCAGGCTGG 4561 TCACAAACTC CTGAGCTCAG GCCATCCGCC CGCCTCGGCC TCCCAAAGCG CTGGGATAAC 4621 AGGCGTGACG CCGCGCCTGG CTTCTTAATT GTTCTAACAG CAGCGACAAC AACAAAAACC 4681 CAGCTCTGAG ATTCCAGCCC CGGCGACTCT AACAGTCCCA GGCCCGATCC CTCACCTAGA 4741 ACCGAGATGC CAGCCCTGAC TCCACAGACT TCACCCCCAA CCCCCACACT CAGCTCTGGA 4801 AGCCCGTCCT GACTCCAGCC TCCATTTTCG GAACCCCACA GCCTGAAGAG CTCCCGGCCT 4861 AAACACTTCA CCCCACGCGC CACAGTCCCC CTGTGAATAT GCAGCCCCGA TTCAGCTGCA 4921 GCTCCACAGC ACCCCTGCCC TGCACCCCCG CTGCACCCCC TACCTGTAC TCACCTCTCT 4981 CCTCTCCCCA CAGATGTCCC GCCTGGCCCT TCCCCAGCCA CCCCCGGACC CGCCGGCGCC 5041 CCCGCTCGCG CCCCCCTCCT CAGCCTGGGG GGGCATCAGG GCCCCCACG CCATCCTGGG 5101 GGGCTGCAC CTGACACTTC ACTGGGCCGT GAGGGGACTG CTGCTGCTGA AGACTCGGCT 5161 GTGACCCGGG GCCCAAAGCC ACCACCGTCC TTCCAAAGCC AGATCTTATT TATTTATTTA 5221 TTTCAGTACT GGGGGCGAAA CAGCCAGGTG ATCCCCCCGC CATTATCTCC CCCTAGTTAG 5281 AGACAGTCCT TCCGTGAGGC CTGGGGGGCA TCTGTGCCTT ATTTATACTT ATTTATTTCA 5341 GGAGCAGGGG TGGGAGGCAG GTGGACTCCT GGGTCCCCGA GGAGGAGGGG ACTGGGGTCC 5401 CCGATTCTTG GGTCTCCAAG AAGTCTGTCC ACAGACTTCT ACCCTGGCTC TTCCCCATCT 5461 AGGCCTGGC AGGAACATAT ATTATTTATT TAAGCAATTA CTTTTCATGT TGGGGTGGGG 5521 ACGGAGGGGA AAGGGAAGCC TGGGTTTTTG TACAAAAATG TGAGAAACCT TTGTGAGACA 5581 GAGAACAGGG AATTAAATGT GTCATACATA TCCACTTGAG GGCGATTTGT CTGAGAGCTG 5641 GGGCTGATG CTTGGGTAAC TGGGGCAGGG CAGGTGGAGG GGAGACCTCC ATTCAGGTGG 5701 AGGTCCCGAG TGGGCGGGGC AGCGACTGGG AGATGGGTCG GTCACCCAGA CAGCTCTGTG 5761 GAGGCAGGGT CTGAGCCTTG CCTGGGGCCC CGCACTGCAT AGGGCCGTTT GTTTGTTTTT 5821 TCAGATGGAG TCTCGCTCTG TTGCCTAGGC TGGAGTGCAG TGAGGCAATC TAAGGTCACT 5881 GCAACCTCCA CCTCCCGGGT TCAAGCAATT CTCCTGCCTC AGCCTCCCGA TTAGCTGGGA 5941 TCACAGGTGT GCACCACCAT GCCCAGCTAA TTATTTATTT CTTTTGTATT TTTAGTAGAG 6001 ACAGGGTTTC ACCATGTTGG CCAGGCTGGT TTCGAACTCC TGACCTCAG TGATCCTCCT 6061 GCCTCGGCCT CCCAAAGTGC TGGGATTACA GCTGTGAGCC ACCACACCTG ACCCATAGGT 6121 CTTCAATAAA TATTTAATGG AAGGTTCCAC AAGTCACCCT GTGATCAACA GTACCCGTAT 6181 GGGACAAAGC TGCAACGGTCA AGATGGTTCA TTATGGCTGT GTTCACCATA GCAAACTGGA 6241 AACAATCTAG ATATCCAACA GTGAGGGTTA AGCAACATGG TAGCATCTGTG GATAGAACGC 6301 CACCCAGCCG CCCGGAGCAG GGACTGTCAT TCAGGGAGGC TAAGGAGAGA GGCTTGCTTG 6361 GGATATAGAA AGATATCCTG ACATTGGCCA GGCATGGTGG CTCACGCCTC TAATCCTGGC 6421 ACTTTCGGAG GACGAAGCGA GTGGATCACT GAAGTCCAAG AGTTTGAGAC CGGCCTGCGA 6481 GACATGGCAA AACCCTGTCT CAAAAAAGAA AGAATGATGT CCTGACATGA AACAGCAGGC WO 00/09525 PCT/US99/17712 EPI-109 691 6541 TACAAAACCA CTGCATGCTG TGATCCCAAT TTTGTGTTTT TCTTTCTATA TATGGATTAA 6601 AACAAAAATC CTAAAGGGAA ATACGCCAAA ATGTTGACAA TGACTGTCTC CAGGTCAAAG 6661 GAGAGAGGTG GGATTGTGGG TGACTTTTAA TGTGTATGAT TGTCTGTATT TTACAGAATT 6721 TCTGCCATGA CTGTGTATTT TGCATGACAC ATTTTAAAAA TAATAAACAC TATTTTTAGA 6781 ATAACAGAAT ATCAGCCTCC TCCTCTCCAA AAATAAGCCC TCAGGAGGGG ACAAAGTTGA 6841 CCGCTGATTG AGCCTGTCAG GGCTGTGCAC (2) INFORMATION FOR SEQ ID NO:2524: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1681 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2524: 1 gctgtagctg gtgagaggaa gtcctagagg ctatggacac tctgctgctg ggatcaccga 61 gatgagcagc agctgctcag ggctgagcag ggtcctggtg gccgtggcta cagccctggt 121 gtctgcctcc tccccctgcc cccaggcctg gggcccccca ggggtccagt atgggcagcc 181 agggaggtcc gtgaagctgt gttgtcctgg agtgactgcc ggggacccag tgtcctggtt 241 tcgggatggg gagccaaagc tgctccaggg acctgactct gggctagggc atgaactggt 301 cctggcccag gcagacagca ctgatgaggg cacctacatc tgccagaccc tggatggtgc 361 acttgggggc acagtgaccc tgcagctggg ctaccctcca gcccgccctg ttgtctcctg 421 ccaagcagcc gactatgaga acttctcttg cacttggagt cccagccaga tcagcggttt 481 acccacccgc tacctcacct cctacaggaa gaagacagtc ctaggagctg atagccagag 541 gaggagtcca tccacagggc cctggccatg cccacaggat cccctagggg ctgcccgctg 601 tgttgtccac ggggctgagt tctggagcca gtaccggatt aatgtgactg aggtgaaccc 661 actgggtgcc agcacacgcc tgctggatgt gagcttgcag agcatcttgc gccctgaccc 721 accccagggc ctgcgggtag agtcagtacc aggttacccc cgacgcctgc gagccagctg 781 gacataccct gcctcctggc cgtgccagcc ccacttcctg ctcaagttcc gtttgcagta 841 ccgtccggcg cagcatccag cctggtccac ggtggagcca gctggactgg aggaggtgat 901 cacagatgct gtggctgggc tgccccatgc tgtacgagtc agtgcccggg actttctaga 961 tgctggcacc tggagcacct ggagcccgga ggcctgggga actccgagca ctgggaccat 1021 accaaaggag ataccagcat ggggccagct acacacgcag ccagaggtgg agcctcaggt 1081 ggacagccct gctcctccaa ggccctccct ccaaccacac cctcggctac ttgatcacag 1141 ggactctgtg gagcaggtag ctgtgctggc gtctttggga atcctttctt tcctgggact 1201 ggtggctggg gccctggcac tggggctctg gctgaggctg agacggggtg ggaaggatgg 1261 atccccaaag cctgggttct tggcctcagt gattccagtg gacaggcgtc caggagctcc 1321 aaacctgtag aggacccagg agggcttcgg cagattccac ctataattct gtcttgctgg 1381 tgtggataga aaccaggcag gacagtagat ccctatggtt ggatctcagc tggaagttct 1441 gtttggagcc catttctgtg agaccctgta tttcaaattt gcagctgaaa ggtgcttgta 1501 cctctgattt caccccagag ttggagttct gctcaaggaa cgtgtgtaat gtgtacatct 1561 gtgtccatgt gtgaccatgt gtctgtgaag gccagggaac atgtattcct ctgcatgcat 1621 gtatgtaggt gcctgggag' gtgtgtggtc cttgctctgg ccctttccct tgcagggttg 1681 tgcaggtgtg aataaa (2) INFORMATION FOR SEQ ID NO:2525: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1681 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2525: 1 ggaagatgag cagcagctgc tcagggctga gcagggtcct ggtggccgtg gctacagccc 61 tggtgtctgc ctcctccccc tgcccccagg cctggggccc cccaggggtc cagtatgggc 121 agccaggcag gtccgtgaag ctgtgttgtc ctggagtgac tgccggggac ccagtgtcct 181 ggtttcggga tggggagcca aagctgctcc agggacctga ctctgggcta gggcatgaac 241 tggtcctggc ccaggcagac agcactgatg agggcaccta catctgccag accctggatg 301 gtgcacttgg gggcacagtg accctgcagc tgggctaccc tccagcccgc cctgttgtct 361 cctgccaagc agccgactat gagaacttct cttgcacttg gagtcccagc cagatcagcg 421 gtttacccac ccgctacctc acctcctaca ggaagaagac agtcctagga gctgatagcc 481 agaggaggag tccatccaca gggccctggc catgcccaca ggatccccta ggggctgccc 541 gctgtgttgt ccacggggct gagttctgga gccagtaccg gattaatgtg actgaggtga 601 acccactggg tgccagcaca cgcctgctgg atgtgagctt gcagagcatc ttgcgccctg 661 acccacccca gggcctgcgg gtagagtcag taccaggtta cccccgacgc ctgcgagcca 721 gctggacata ccctgcctcc tggccgtgcc agccccactt cctgctcaag ttccgtttgc 781 agtaccgtcc ggcgcagcat ccagcctggt ccacggtgga gccagctgga ctggaggagg 841 tgatcacaga tgctgtggct gggctgcccc atgctgtacg agtcagtgcc cgggactttc 901 tagatgctgg cacctggagc acctggagcc cggaggcctg gggaactccg agcactggga 961 ccataccaaa ggagatacca gcatggggcc agctacacac gcagccagag gtggagcctc 1021 aggtggacag ccctgctcct ccaaggccct ccctccaacc acaccctcgg cacttgatc WO 00/09525 PCT/US99/17712 EPI-109 692 1081 acagggactc tgtggagcag gtagctgtgc tggcgtcttt gggaatcctt tctttcctgg 1141 gactggtggc tggggccctg gcactggggc tctggctgag gctgagacgg ggtgggaagg 1201 atggatcccc aaagcctggg ttcttggcct cagtgattcc agtggacagg cgtccaggag 1261 ctccaaacct gtagaggacc caggagggct tcggcagatt ccacccataa ttctgtcttg 1321 ctggtgtgga tagaaaccag gcaggacagt agatccctat ggttggatct cagctggaag 1381 ttctgtttgg agcccatttc tgtgagaccc tgtatttcaa atttgcagct gaaaggtgct 1441 tctacctctg atttcacccc agagttggag ttctgctcaa ggaacatgtg taatgtgtac 1501 atctgtgtcc atgtgtgacc atgtgtctgt gaggcaggga acagtattc tctgcatgca 1561 tgtatgtagg tgcctgggga gtgtgtgtgg gtccttggct cttggccttt ccttgcaggg 1621 gttgtgcagg tgtgaataaa gagaataagg aagttcttgg agatatact cagaaaaaaa 1681 aa (2) INFORMATION FOR SEQ ID NO:2526: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 361 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2526: 1 tctgtggagc aggtagctgt gctggcgtct ttgggaatcc tttctttcct gggactggtg 61 gctggggccc tggcactggg gctctggtaa gtgactgcca ttggtccctc agcctctgat 121 cctcacacat gctctgatgc ccatagacca cattcatctc cacccttcat gactgcctgc 181 tgaacctgtc tgattctgga actacctccc catacctcca tcccctatgc cccacttgat 241 tttaactgat tcctctcctg accctttact aataaaccct ttggcggaga ctgagataac 301 ccacattgtt ggagagacag ctgcctttct atgccccagg ctgaggctga gacggggtgg 361 gaaggatgga tccccaaagc ctgggttctt ggcctcagtg attccagtgg aca (2) INFORMATION FOR SEQ ID NO:2527: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: - base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2527: 1 gctgtagctg gtgagaggaa gtcctagagg ctatggacac tctgctgctg ggatcaccga 61 gatgagcagc agctgctcag ggctgagcag ggtcctggtg gccgtggcta cagccctggt 121 gtctgcctcc tccccctgcc cccaggcctg gggcccccca ggggtccagt atgggcagcc 181 agggaggtcc gtgaagctgt gttgtcctgg agtgactgcc ggggacccag tgtcctggtt 241 tcgggatggg gagccaaagc tgctccaggg acctgactct gggctagggc atgaactggt 301 cctggcccag gcagacagca ctgatgaggg cacctacatc tgccagaccc tggatggtgc 361 acttgggggc acagtgaccc tgcagctggg ctaccctcca gcccgccctg ttgtctcctg 421 ccaagcagcc gactatgaga acttctcttg cacttggagt cccagccaga tcagcggttt 481 acccacccgc tacctcacct cctacaggaa gaagacagtc ctaggagctg atagccagag 541 gaggagtcca tccacagggc cctggccatg cccacaggat cccctagggg ctgcccgctg 601 tgttgtccac ggggctgagt tctggagcca gtaccggatt aatgtaactg aggtgaaccc 661 actgggtgcc agcacacgcc tgctggatgt gagcttgcag agcatcttgc gccctgaccc 721 accccagggc ctgcgggtag agtcagtacc aggttacccc cgacgcctgc gagccagctg 781 gacataccct gcctcctggc cgtgccagcc ccacttcctg ctcaagttcc gtttgcagta 841 ccgtccggcg cagcatccag cctggtccac ggtggagcca gctggactgg aggaggtgat 901 cacagatgct gtggctgggc tgccccatgc tgtacgagtc agtgcccggg actttctaga 961 tgctggcacc tggagcacct ggagcccgga ggcctgggga actccgagca ctgggaccat 1021 accaaaggag ataccagcat ggggccagct acacacgcag ccagaggtgg agcctcaggt 1081 ggacagccct gctcctccaa ggccctccct ccaaccacac cctcggctac ttgatcacag 1141 ggactctgtg gagcaggtag ctgtgctggc gtctttggga atcctttctt tcctgggact 1201 ggtggctggg gccctggcac tggggctctg gctgaggctg agacggggtg ggaaggatgg 1261 atccccaaag cctgggttct tggcctcagt gattccagtg gacaggcgtc caggagctcc 1321 aaacctgtag aggacccagg agggcttcgg cagattccac ctataattct gtcttgctgg 1381 tgtggataga aaccaggcag gacagtagat ccctatggtt ggatctcagc tggaagttct 1441 gtttggagcc catttctgtg agaccctgta tttcaaattt gcagctgaaa ggtgcttgta 1501 cctctgattt caccccagag ttggagttct gctcaaggaa cgtgtgtaat gtgtacatct 1561,gtgtccatgt gtgaccatgt gtctgtgaag gccagggaac atgtattcct ctgcatgcat 1621 gtatgtaggt gcctgggagt gtgtgtggtc cttgctctgg ccctttccct tgcagggttg 1681 tgcaggtgtg aataaa 1 ggaagatgag cagcagctgc tcagggctga gcagggtcct ggtggccgtg gctacagccc 61 tggtgtctgc ctcctccccc tgcccccagg cctggggccc cccaggggtc cagtatgggc 121 agccaggcag gtccgtgaag ctgtgttgtc ctggagtgac tqccggggac ccagtgtcct 181 ggtttcggga tggggagcca aagctgctcc agggacctga ctctgggcta gggcatgaac 241 tggtcctggc ccaggcagac agcactgatg agggcaccta catctzccag accctggatg 301 gtgcacttgg gggcacagtg accctgcagc tgggctaccc tccagcccgc cctgttgtct WO 00/09525 PCT/US99/17712 EPI-109 693 361 cctgccaagc agccgactat gagaacttct cttgcacttg gagtcccagc cagatcagcg 421 gtttacccac ccgctacctc acctcctaca ggaagaagac agtcctagga gctgatagcc 481 agaggaggag tccatccaca gggccctggc catgcccaca ggatccccta ggggctgccc 541 gctgtgttgt ccacggggcqt gagttctgga gccagtaccg gattaatgtg actgaggtga 601 acccactggg tgccagcaca cgcctgctgg atgtgagctt gcagagcatc ttgcgccctg 661 acccacccca gggcctgcgg gtagagtcag taccaggtta cccccgacgc ctgcgagcca 721 gctggacata ccctgcctcc tggccgtgcc agccccactt cctgctcaag ttccgtttgc 781 agtaccgtcc ggcgcagcat ccagcctggt ccacggtgga gccagctgga ctggaggagg 841 tgatcacaga tgctgtggct gggctgcccc atgctgtacg agtcagtgcc cgggactttc 901 tagatgctgg cacctggagc acctggagcc cggaggcctg gggaactccg agcactggga 961 ccataccaaa ggagatacca gcatggggcc agctacacac gcagccagag gtggagcctc 1021 aggtggacag ccctgctcct ccaaggccct ccctccaacc acaccctcgg ctacttgatc 1081 acagggactc tgtggagcag gtagctgtgc tggcgtcttt gggaatcctt tctttcctgg 1141 gactggtggc tggggccctg gcactggggc tctggctgag gctgagacgg ggtgggaagg 1201 atggatcccc aaagcctggg ttcttggcct cagtgattcc agtggacagg cgtccaggag 1261 ctccaaacct gtagaggacc caggagggct tcggcagatt ccacctataa ttctgtcttg 1321 ctggtgtgga tagaaaccag gcaggacagt agatccctat ggttggatct cagctggaag 1381 ttctgtttgg agcccatttc tgtgagaccc tgtatttcaa atttgcagct gaaaggtgct 1441 tctacctctg atttcacccc agagttggag ttctgctcaa ggaacgtgtg taatgtgtac 1501 atctgtgtcc atgtgtgacc atgtgtctgt gaggcaggga acatgtattc tctgcatgca 1561 tgtatgtagg tgcctgggga gtgtgtgtgg gtccttggct cttggccttt ccttgcaggg 1621 gttgtgcagg tgtgaataaa gagaataagg aagttcttgg agattatact cagaaaaaaa 1681 aa 1 tctgtggagc aggtagctgt gctggcgtct ttgggaatcc tttctttcct gggactggtg 61 gctggggccc tggcactggg gctctggtaa gtgactgcca ttggtccctc agcctctgat 121 cctcacacat gctctgatgc ccatagacca cattcatctc cacccttcat gactgcctgc 181 tgaacctgtc tgattctgga actacctccc catacctcca tcccctatgc cccacttgat 241 tttaactgat tcctctcctg accctttact aataaaccct ttggcggaga ctgagataac 301 ccacattgtt ggagagacag ctgcctttct atgccccagg ctgaggctga gacggggtgg 361 gaaggatgga tccccaaagc ctgggttctt ggcctcagtg attccagtgg aca (2) INFORMATION FOR SEQ ID NO:2528 (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 901 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2528: 1 cttcaactca ataagcattt taagtattct aatcttagta tttctctagc tgacatgtaa 61 gaagcaatct atcttattgt atgcaattag ctcattgtgt ggataaaaag gtaaaaccat 121 tctgaaacag gaaaccaata cacttcctgt ttaatcaaca aatctaaaca tttattcttt 181 tcatctgttt actcttgctc ttgtccacca caatatgcta ttcacatgtt cagtgtagtt 241 ttatgacaaa gaaaattttc tgagttactt ttgtatcccc acccccttaa agaaaggagg 301 aaaaactgtt tcatacagaa ggcgttaatt gcatgaatta gagctatcac ctaagtgtgg 361 gctaatgtaa caaagaggga tttcacctac atccattcag tcagtctttg ggggtttaaa 421 gaaattccaa agagtcatca gaagaggaaa aatgaaggta atgttttttc agacaggtaa 481 agtctttgaa aatatgtgta atatgtaaaa cattttgaca cccccataat atttttccag 541 aattaacagt ataaattgca tctcttgttc aagagttccc tatcactctc tttaatcact 601 actcacagta acctcaactc ctgccacaat gtacaggatg caactcctgt cttgcattgc 661 actaagtctt gcacttgtca caaacagtgc acctacttca agttctacaa agaaaacaca 721 gctacaactg gagcatttac ttctggattt acagatgatt ttgaatggaa ttaatgtaag 781 tatatttcct ttcttactaa aattattaca tttagtaatc tagctggaga tcatttctta 841 taacaatgca ttatactttc ttagaattac aagaatccca aactcaccag gatgctcaca 901 tttaagtttt acatgcccaa gaaggtaagt acaatatttt (2) INFORMATION FOR SEQ ID NO:2529: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 9301 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2529: 1 gaattccctt ttcctagtca aagaaagggg tgacagacag cacctggaaa atcgtgtcac 61 tcccacccta atactgcgct tttccaatgg tcttagcaaa cagcacacca agagattata 121 tccagcacct ggctcagagg gtcctatgcc cacggagcct cactcactgc tagcacagca 181 gtctgagatc aaactgcaag gtggcagtga ggctgggaga ggggtgtgca ccattgccga 241 ggcttgagta ggtaaacaaa gcagctggga agctcgaact gggtggagcc cactgcagct 301 caaggaggcc tgcctgcctc tgtagactcc acctccgggg gcagggcata gccaaacaaa 361 aggcagcaga aacctctgca gacttaaatg tccctgtctg acagcttgga agagagtagt WO 00/09525 PCT/US99/17712 EPI-109 694 421 ggttctccca gcatgcaact tgagatctga gaatggacag actgcctcct caagtgggtc 481 cctgaccccc gagtaaccta actgggaggc accccaagta ggggcagact gacacctcac 541 atggctgggt actcctctga gaaaaaactt ccagaggaac gatcaggcag caacatttgc 601 tgttcaccaa tatcCacrgt tctgcagcct cctgtgctaa tacccaggca aatgggtctg 661 gagaggacct ccagcaagct ccaacagacc tacagctgag ggtcctgact gttagaagga 721 aaactaacaa acagaaagga catccacacc aaaaccctat ctgtacggca ccatcatcaa 781 agaccaaagg tagataaaac cacaaagatg gggaaaaaaa cacagcagaa aaactggtaa 841 ctctaaaaat tagagcgctt ctcctcctcc aaaggaacgc agctcctcac cagcaatgga 901 accaagctgg acagagaatg actttgacga gttgagagaa gaaggcttca gatgatcaaa 961 ctactctgag ctaaaggagg aagttcgaac ccacggcaaa gaagttaaaa accttgaaaa 1021 aaattagatg aatggctaac tagaataacc aatgcagaga agtccttaaa ggacctgatg 1081 gagctgaaaa ccatggcaca agaactacat gacaaatgca caagcctcag tagctgattc 1141 gatcaactgg aagaaagggt atcagtgatg gaagatcaaa tgaatgaaat gaagcaagaa 1201 gagaagttta gagaaaaaag aaaaaaaaga aatgaacaaa gcctccaaga aatatgggac 1261 tatgtgaaaa gaccaaatct acgtctgatt ggtgtacctg aaagtgatgg ggagaatgga 1321 accaagctgg aaaacactct gcaggatatt atccaagaga acttccccaa tctagcaagg 1381 caggctgaca ttcaaattca ggaaatacag agaacgccac aaatataatc ctcgagaaga 1441 gcaactccaa gacacataat tgttagattc actaaagttg aaatgaagga aaaaatgtta 1501 agggcagcca gagagaaagg tcagcttacc cacaaaqgaa agcccatcag attaacagct 1561 gatctctcgg cagaaactct acaagccaga agagagtggg ggccaatatt caacattctt 1621 aaagaaaaga attttcaacc cagaatttca tatccagcca aactatgctt cataagtgaa 1681 ggagaaataa aatatagaca agtgaacgat gaaagatttt gtcaccacca ggcctgccct 1741 acaagagctc ctgaaggaag cactaaacat ggaaaggaac aaccggtacc agccactgca 1801 aaaacatgcc aaattgtaaa caccattgag gccaggaaga aactgcatca actaacgagc 1861 aaaataacca gctaacatca tcatgacagg atcaaattca cacataacaa tattaacctt 1921 aaatgtaaat aggctaaatg ctccaattaa aagacacaga ctggcaaact ggataaagag 1981 tcaagaccca tcagtgtgct gtattcagga aacccatctc acgtgcagag acacacatag 2041 gctcaaaata aagggatgga ggaagatcta ccaaacaaac ggaaaacaaa aaaaggcagg 2101 ggttgcaatc ctagtctctg ataaaacaga ctttaaacca acaaagatca aaagagacac 2161 agaaggccat tacataatgg taaagggatc aattcaacaa gaagagttaa ctatcctaaa 2221 tatatatgca cccaatacag gagcacctag attcataaag caagtcctta gagacctaca 2281 aagagactta gactcccaca caataataat gggagacttt aacaccccac tgtcaacatt 2341 agacagatca atgagacaga aaattaacaa ggatatccag gaattgaact caactctgca 2401 ccaagcggac ctaatagaca tctacagaac tctccacccc aaatcaacag aatatacatt 2461 cttttcggca ccacaccaca ccgattccaa aattgaacac atagttggaa gtaaagcact 2521 cctcagcaaa tgtaaaagaa cagaaagtac aacaaactgt ctctcagacc acagtgcaat 2581 caaactaaaa ctcaggatta agaaactcac tcaaaaccgc tcaactacat ggaaactgaa 2641 caacctgctc ctgaatgact actgggtaca taacgaaatg aaggcagaag taaagatgtt 2701 ctttgaaacc aacgagaaca aagacacaac ataccagaat ctctgggaca cattcaaagc 2761 agtgtgtaga ggaaaattta tagcactaaa tgcccacaag agaaagcagg aaagatctaa 2821 aattgacagc ctaacatcac aattaaaaga actagagaaa caagagcaaa cacattcaaa 2881 agctagcaga aggcaagaaa taactacaat cagagcagaa ctgaaggaga tagagacata 2941 caaaaaaccc ttcaaaaaat caatgaatcc aggagctggt tttttgaaaa gatcaacaaa 3001 attgatagac cactagcaaa actaatacag aagagagaag aatcaaatag acacaataaa 3061 aaatgataaa cgggatatca ccactgatcc cacagaaata caaactacca tcaaagaata 3121 ctataaacac ctctatgcaa ataaactaga aaatctagaa gaaatggata aattcctcga 3181 cacatacacc ctcccaagac taaaccagga agaagctgaa tctctgaata gaccaataac 3241 aggctctgaa attgaggcaa caattaacac cttaccaacc aataaaagtc caggaccaga 3301 tggattcaca gccaaattct accagaggta caaggaggag ctggtacgat tccttctgaa 3361 actattccaa tcaatagaaa aagagggaat cctccctaac tcattttatg aggccagcat 3421 catcctgata ccaaagcctg gcagagacac aacaaaaaaa gagaatttca gaccaatatc 3481 cctgatgaac atcgatgcaa aaatttttaa taaaatactg gcaaactgaa tccagcagca 3541 catcacaaag cttatccacc atgatcaagc tggcttcatt cctgggatgc aaggctggtt 3601 caacatacgg aaaatcaata aatgtaatcc agcatataaa cagaaccaac aacacacaac 3661 acatgattat ctcaacagat gcagaaaagg cctttgacaa aattcaacag cccttcatgc 3721 taaaaactct caataaatta ggtactgatg ggacgtatct caaaataata agcgctatct 3781 atgaccaacc cacagccaat atcatactgg atgggcaaaa actggaagca ttccctttga 3841 aaactggcac aagacaggga tgccctctct caccactcct attcaacaca gtgttcgaag 3901 ttctggcagg gcaatcaggc aggagaaaga aataaagggt attcaattag gaaaagagga 3961 ggtcaaattg tccctgtttg cagatgacat gattgtatat atagaaaacc ccattgtctc 4021 agcccaaaat ctccttaagc tgataagcaa cttcagcaaa gtctcaggat caaaatcaat 4081 gtgcaaaaat cacaagcatt cttatacacc aataacagac aaacagagag ccaaatcatg 4141 agtgaactcc cattcacaat tgcttcaaag agaataaaat acctaggaat ccaactcaca 4201 agggatgtga gagacctctt caaggagaac tataaaccac tgctcaatga aatgagagga 4261 tacagataaa tggaagaaca ttccatgctc atgggtagga agaatcaata tcgtgaaaat 4321 ggccatactg cccaaggtaa ttttatagat tcaatgccat ccccatcaag ctaccaatga 4381 ctttcttcac agaattggaa aaaactactt taaagttcat atggaaccaa aaaagagccc 4441 gcattgccaa gtcaatccta agccaaaaga acaaagctag aggcatcaca ctacctgact WO 00/09525 PCTIUS99/17712 EPI-109 695 4501 tcaaactata ctacaaggct acagtaacca aaacagcatg gtactggtac caaagcagag 4561 atatagacca atggaacaaa acagtgccct cagaaataat actgcatatc tacaaccatc 4621 tgatctttga caaacctgac aaaaacaagc aatggggaaa ggattcccta tttaataaat 4681 ggtgctggga aaactggcta gccatatgta gaaagctgaa attggatccc ttccttacac 4741 cttgtacaaa aattaattca agatggatta cagacttaaa tgttagacct aaaaccataa 4801 aaaccctaga agaaaaccta ggcaatacca ttcaggacat aggcatgggc aagaacttca 4861 tgtctagaac accaaaagta atggcaacaa aagccaaaat tgacaaatgg gtctaattaa 4921 actaaagagc ttctgcacag caaaagaaac taccatcaga gtgaagaggc aacctacaga 4981 atgggagaaa atttttgcaa tctgacaaaa gggctaattt ttgcatctga caaagggcta 5041 atatccagaa tctacaatga actcaaacaa atttacaaga aaaaaacaaa tttacaagaa 5101 aaaaacaaaa tttacaagaa aaaaacaaat ttacaagaaa aaaacaaaca accccatcaa 5161 aaagtgggca aaggataaga acagtcactt ctcaaaagaa gacatttatg cagccaaaag 5221 acacatgaaa aaattctcat catcactggc catcagagaa atgcaaatca aaaccacaat 5281 gagataccat ctcacaccag ttagaatggc gatcattaaa aagtcaagaa acaacaggtg 5341 ctggagagga tgtggagaaa taggaacact tttacactgt tagtgggact gtaaactagt 5401 tcaacattgt ggaaatcagt atggcgattc ctcagggatc tagaactaga aataccattt 5461 gacccagcca tcccattact gggtatatac ccaaaggatt ataaatcatg ctgctataaa 5521 gacacttgca cacatatgtt tattgtggta ctattcacaa tagcaaagac ttggaattaa 5581 cccaaatgtc caacaatgat agactagatt aagaaaatgt ggcacatata cactatggaa 5641 tactttgcag ccataaaaaa ggatgagttc atgtcctttg tagggacatg gatgaagctg 5701 gaaaccatca ttctcggcaa actatcgcaa ggtcaaaaaa ccaaacaccg catgttctca 5761 ctcataggtg gtaactgaac aatgagaaca catggtcaca ggaaggggaa catcacgcac 5821 tggggcctgt tgtggggtgg ggggagtggg cagggatagc attaggagac atacctaatg 5881 ttaaatgacg atttaatggg tgcagcacac caacatggca catgtataca tatgtaacaa 5941 acccacacgt tgtgcacatg tactctaaaa cttaaagtat aattaaaata aataaataaa 6001 gtaaaaaaga aatcctaagg atactcaaat tgttgtttag gtgaagatgg atgatgcctt 6061 ccttgaatca tcagctacca ccgacagagt gaagtgagat ggaatagtgg gcacaatctc 6121 attcatccta ctctatgtag cctaatgggt ccagaattta tcatcactat tttacactgg 6181 aaaaaagatg agattatgag gggtcaggga ggctttgagt ttttgctcta acttcaccac 6241 taattaagaa tgtgatcttg ggtaagccac tttaacctct gtaaatgtca aatttcttat 6301 cagtaaaatg tgactataca agacaataaa tttgaaaata ctttgcaaaa ttgaaagtac 6361 catggaaata attcttcaat cccaaaaggt tatgaacatt attaaaattt gccacatgga 6421 agagcacaca ccacagagac ataactgtga tcataaacag atttacaaaa gtggtgtttc 6481 attatggagg gccatagggc tgataaagac aaatgcatca ccaagctatg tccgagctca 6541 ttcagatttt tacaggaaac acagagcttc tagctgaatt atctctggat ggtgtggaaa 6601 ttgtccaaca cgttcctaat ttcaaagaaa cagaactgaa tcttgaaaac ccaagaggcc 6661 tttacagaaa ctgacaagag atgaattaat ataggtatca agctacagac caaattaaag 6721 ttttacaaaa ctttgaaaga gggtcagaaa gaagaaactt atgggaagca gagtcctgga 6781 aagtcagctt tgatggagtg acaatatgtg caacacagtg agcaatctct taggtaggca 6841 gcttcaggga tgggggttgc cctttgaaag gacttgggcc actcttgagt ctaagaggct 6901 aagtcacaaa caatgctaag caactaaaaa tagcttcttg tttaatagta aaattctgca 6961 tagtaaaagg agaagcaggg ggtatgacac acgtggtagt tagcagtcta ctagtgactt 7021 tactgccaca accagaaaag ccagctgatg tgtcagacgt gagaaagcga aagtatgtca 7081 cagcgaatgt agcttttcca cacgtatttc aagaaagaaa tgaaaaaggc caacttctat 7141 aatggtgcct actgtgcatt aacagagata aactaggggt ctaagaactc agttttctac 7201 agggtcccag aagtatagcc atatattgcc ccattctcta atggaaatag ccagagaaat 7261 agaaatatca agactggaga acatcaaata cctcattgga aaagccccca cataggaaaa 7321 tgtgtgggct tgaattcttc cattctggaa gggtaaaggc ctgagtgatg atgctgggat 7381 tagacactga aactctttag agaagcaaaa caagtataat aaagctgtac tttattatat 7441 taaataaata acacacagac taccaaatag cctgcccctt ataacagcgt taatgtgatt 7501 ttgatctgaa atgtatagag acattttgca ttttttcggt ataaaaagtt catgagattt 7561 ggccctaatc tggacctttt cttcattttt ttttctactt gagggactat aatctttatt 7621 tttaaatttg ttttatattc tccgaacatt acctaacgca tagaaaactc ttcttgaacc 7681 atttttctct gttctttgta aaatattaca tttgactgtt ccttagactg ctttaatcat 7741 tcctgcctat gcaccctcct caaaatccag tttaaattaa ttgttcctta ttcaagattc 7801 cttatatcca cctcccttgg ggcagcaatc acctatcacc caggactaca cttgtgtatg 7861 tacatatctt ccctattaca aatcaggttc tttgaaaaaa tacaaatggt aagagagtgg 7921 atttttggag tcagtacatt ctcttttcaa atccttcttc tgccccttac tggcaataag 7981 ggctgagtga cctagagcaa attacttaac ttctctgagc ctcagttttc taatctgcaa 8041 aataggagcc atcacttcac aagtctgtaa gacttatatt agactaagtg cctgcctgta 8101 cactgttctc ttttctctct ttctatatac ctgaaggcat tataggtgct agatgtctgt 8161 ttaaagacca gacaatattg tcttaaaaaa acaaacaaaa acacagacaa taccatcttt 8221 aaaaaaaaaa aaaagtccag gtaagaaata aataaggcca tagaatggaa gctttacaag 8281 gactctctgt gagacaggat ctcctcaagt gtccccaggt taaattagaa gtatatatcc 8341 gtacaattgt tcagccagtt tgtgcactgt actgaggatg aatgaacacc tatcctaaat 8401 atcctagtct tctgactaaa aacaagatca tatttcataa cgattattgt tacattcata 8461 gtgtcccagg tgatttagag gataaataaa aatccattaa agaggtaaag acataaaaac 8521 gagaaacatg gactggttta cacataacac atacaaagtc tattataaaa ctagcatcag WO 00/09525 PCT/US99/17712 EPI-109 696 8581 tatccttgaa zgcaaacctt tttctgagta tttaacaatc gcacccttta aaaaatgtac 8641 aatagacatt aagagactta aacagatata taatcatttt aaattaaaat agcgttaaac 8701 agtacctcaa actcaataag cattttaagt attctaatct tagtatttct ctagctgaca 8761 tgtaagaagc aatctatctt attgtatgca attagctcat tgtgtggata aaaaggtaaa 8821 accattctga aacaggaaac caatacactt cctgtttaat caacaaatct aaacatttat 8881 tcttttcatc tgtttactct tgctgttgtc caccacaata tgctattcac atgttcagtg 8941 tagttttatg acaaagaaaa ttttctgagt tacttttgta tccccacccc cttaaagaaa 9001 ggaggaaaaa ctgtttcata cagaaggcgt taattgcatg aattagagct atcacctaag 9061 tgtgggctaa tataacaaag agggatttca cctacatcca ttcagtcagt ctttgggggt 9121 ttaaagaaat tccaaagagt catcagaaga ggaaaaatga aggtaatgtt ttttcagaca 9181 ggtaaagtct ttgaaaatat gtgtaatatg taaaacattt tgacaccccc ataatatttt 9241 tccagaatta acagtataaa ttgcatctct tgttcaagag ttccctatca ctctctttaa 9301 tcactactca cagtaacctc aactcctgcc acaatgtac (2) INFORMATION FOR SEQ ID NO:2530: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 5701 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2530: 1 ttaatcaaca aatctaaaca tttattcttt tcatctgttt actcttgctc ttgttcacca 61 caatatgcta ttcacatgtt cagtgtagtt ttatgacaaa gaaaattttc tgagttactt 121 ttgtatcccc acccccttaa agaaaggagg aaaaactgtt tcatacagaa ggcgttaatt 181 gcatgaatta gagctatcac ctaagtgtgg gctaatgtaa caaagaggga tttcacctac 241 atccattcag tcagtctttg ggggtttaaa gaattccaaa gagtcatcag aagaggaaaa 301 atgaaggtaa tgttttttca gacaggtaaa gtctttgaaa atatgtgtaa tatgtaaaac 361 attttgacac ccccataata tttttccaga attaacagta taaattgcat ctcttgttca 421 agagttccct atcactctct ttaatcacta ctcacagtaa cctcaactcc tgccacaatg 481 tacaggatgc aactcctgtc ttgcattgca ctaagtcttg cacttgtcac aaacagtgca 541 cctacttcaa gttctacaaa gaaaacacag ctacaactgg agcatttact gctggattta 601 cagatgattt tgaatggaat taatgtaagt atatttcctt tcttactaaa attattacat 661 ttagtaatct agctggagat catttcttaa taacaatgca ttatactttc ttagaattac 721 aagaatccca aactcaccag gatgctcaca tttaagtttt acatgcccaa gaaggtaagt 781 acaatatttt atgttcaatt tctgttttaa taaaattcaa agtaatatga aaatttgcac 841 agatgggact aatagcagct catctgaggt aaagagtaac tttaatttgt ttttttgaaa 901 acccaagttt gataatgaag cctctattaa aacagtttta cctatatttt taatatatat 961 ttgtgtgttg gtgggggtgg gaagaaaaca taaaaataat attctcacct ttatcgataa 1021 gacaattcta aacaaaaatg ttcatttatg gtttcattta aaaatgtaaa actctaaaat 1081 atttgattat gtcattttag tatgtaaaat accaaaatct atttccaagg agcccacttt 1141 taaaaatctt ttcttgtttt aggaaaggtt tctaagtgag aggcagcata acactaatag 1201 cacagagtct ggggccagat atctgaagtg aaatctcagc tctgccatgt cctagctttc 1261 atgatctttg gcaaattacc tactctgttt gtgattccagt ttcacgtcta cttaaatgaa 1321 taactgtata tacttaatat ggcattgtga gaattagtaa gttaaatgta aagcactcag 1381 aaccgtgtct ggcataaggt aaataccata caagcattag ctattattag tagtattaaa 1441 gataaaattt tcactgagaa atacaaagta aaattttgga ctttatcttt ttaccaatag 1501 aacttgagat ttataatgct atatgactta ttttccaaga ttaaaagctt cattaggttg 1561 tttttggatt cagatagagc ataagcataa tcatccaagc tcctaggcta cattaggtgt 1621 gtaaagctac ctagtagttg tgccagttaa gagagaatga acaaaatctg gtgccagaaa 1681 gagcttgtgc cagggtgaat ccaagcccag aaaataatag gatttaaggg gacacagatg 1741 caatcccatt gactcaaatt ctattaattc aagagaaatc tgcttctaac tacccttctg 1801 aaagatgtaa aggagacagc ttacagatgt tactctagtt taatcagagc cacataatgc 1861 aactccagca acataaagat actagatgct gttttctgaa gaaaatttct ccacattgtt 1921 catgccaaaa acttaaaccc gaatttgtag aatttgtagt ggtgaattga aagcgcaata 1981 gatggacata tcaggggatt ggtattgtct tgacctacct ttcccactaa agagtgttag 2041 aaagatgaga ttatgtgcat aatttagggg gtggtagaat tcatggaaat ctaagtttga 2101 aaccaaaagt aacgataaac tctattcatt tgttcattta accctcattg cacatttaca 2161 aaagatttta gaaactaata aaaatatttg attccaagga tgctatgtta atgctataat 2221 gagaaagaaa tgaaatctaa ttctggctct acctacttat gtggtcaaat tctgagattt 2281 agtgtgctta tttataaagt ggagatgata cttcactgcc tacttcaaaa gatgactgtg 2341 agaagtaaat gggcctattt tggagaaaat tcttttaaat tgtaatatac catagaaata 2401 tgaaatatta tatataatat aqaatcaaga ggcctgtcca aaagtcctcc caaagtatta 2461 taatctttta tttcactggg acaaacattt ttaaaatgca tcttaatgta gtgattgtag 2521 aaaagtaaaa tttaagacat atttaaaaat gtgtcttgct caaggctata ttgagagcca 2581 ctactacatg attattgtta cctagtgtaa aatgttggga ttgtgataga tggcattcaa 2641 gagttccttc tctctcaaca ttctgtgatt cttaactctt agactatcaa atattataat 2701 cactagaatgt gatttttatg cttccacatt ctaactcatc tggttctaat gattttctat 2761 gcagattgga aaagtaatca gcctgcatct gtgataggca cttacgatgc agaaagtcta 2821 acattttgca aagccaaatt aagctaaaac cagtgagca actatcactt aacgctagtc WO 00/09525 PCT/US99/17712 EPI-109 697 2881 ataggtactt aagccctagt ttttccagtt ttataatgta aactctactg gtccattctt 2941 tacagtgaca zzgagaacag agagaatggt aaaaactaca tactgctact ccaaataaaa 3001 taaattggaa attaatttct gattctgacc tctatgtaaa ctgagctgat gataattatt 3061 attctaggcc acagaactga aacatcttca gtgtctagaa gaagaactca aacctctgga 3121 ggaagtgcta aatttagctc aaagcaaaaa ctttcactta agacccaggg acttaatcag 3181 caatatcaac gtaatagttc tggaactaaa ggtaaggcat tactttattt gctctcctgg 3241 aaataaaaaa aaaaaagtca gggggaaaag taccacattt taaagtgaca taacattttt 3301 ggtatttgta aagtacccat gcatgtaatt agcctacatt ttaagtacac tgtgaacatg 3361 aatcatttct aatgttaaat gattaactgg ggagtataag ctactgagtt tgcacctacc 3421 atctactaat ggacaagcct catcccaaac tccatcacct ttcatattaa cacaaaactg 3481 ggagtgagag aaggtactga gttgagtttc acagaaagca ggcagatttt attatatatt 3541 tttcgattct zcagatcatt tactgaaata gccaatactg attacctgaa aggcttttca 3601 aatggtgttt ccttatcatt tgatggaagg actacccata agagatttgt cttaaaaaaa 3661 aaaactggag ccattaaaat ggccagtgga ctaaacaaac aacaatcttt ttagaggcaa 3721 tccccacttt cagaatctta agtattttta aatgcacagg aagcataaaa tatgcaaggg 3781 actcaggtga tgtaaaagag attcactttt gtctttttat atcccgtctc ctaaggtata 3841 aaattcatga gttaataggt atcctaaata agcagcataa gtatagtagt aaaagacatt 3901 cctaaaagta actccagttg tgtccaaatg aatcacttat tagtggactg tttcagttga 3961 attaaaaaaa tacattgaga tcaatgtcat ctagacattg acagattcag ttccttatct 4021 atggcaagag rtttactcta aaataattaa catcagaaaa ctcattctta actcttgata 4081 caaatttaag acaaaaccat gcaaaaatct gaaaactgtg tttcaaaagc caaacacttt 4141 ttaaaataaa aaatcccaag atatgacaat atttaaacaa ttatgcttaa gaggatacag 4201 aacactgcaa cagtttttta aaagagaata cttatttaaa gggaacactc tatctcacct 4261 gcttttgttc ccagggtagg aatcacttca aatttgaaaa gctctctttt aaatctcact 4321 atatatcaaa atatttcctc cttagcttat caactagagg aagcgtttaa atagctcctt 4381 tcagcagaga agcctaattt ctaaaaagcc agtccacaga acaaaatttc taatgtttaa 4441 acttttaaaa gttggcaaat tcacctgcat tgatactatg atggggtagg gataggtgta 4501 agtatttaga agatgttctt cacacaaatt tatcccaaac ggaagcatgt cctagcttac 4561 tctagtgtag ttctgttctg ctttggggaa aatataagga gattcactta agtagaaaaa 4621 taggagactc taatcaagat ttagaaaaga agaaagtata atgtgcatat caattcatac 4681 atttaactta cacaaatata ggtgtacatt cagaggaaaa gcgatcaagt ttatttcaca 4741 tccagcattt aatatttgtc tagatctatt tttatttaaa tctttatttg cacccaattt 4801 agggaaaaaa tttttgtgtt cattgactga attaacaaat gaggaaaatc tcagcttctg 4861 tgttactatc atttggtatc ataacaaaat atgtaatttt ggcattcatt ttgatcattt 4921 caagaaaatg cgaataatta atatgtttgg taagcttgaa aataaaggca acaggcctat 4981 aagacttcaa ttgggaataa ctgtatataa ggtaaactac tctgtacttt aaaaaattaa 5041 catttttctt ttatagggat ctgaaacaac attcatgtgt gaatatgctg atgagacagc 5101 aaccattgta gaatttctga acagatggat taccttttgt caaagcatca tctcaacact 5161 gacttgataa ttaagtgctt cccacttaaa acatatcagg ccttctattt atttaaatat 5221 ttaaatttta tatttattgt tgaatgtatg gtttgctacc tattgtaact attattctta 5281 atcttaaaac tataaatatg gatcttttat gattcttttt gtgccctagg ggctctaaaa 5341 tggtttcact atttatccc aaaatattta ttattatgtt gaatgttaaa tatagtgcta 5401 tgtagattgg tagtaaaac tatttaataa atttgataaa tataaacaag cctggatatt 5461 tgttattttg gaaacagcac agagtaagca tttaaatatt tcttagttac ttgtgtgaac 5521 tgtaggatgg ttaaaatgct tacaaaagtc actctttctc tgaagaaata tgtagaacag 5581 agatgtagac ttctcaaaag cccttgcttt gtcctttcaa gggctgatca gacccttagt 5641 tctggcatct cttagcagat tatattttcc ttcttcttaa aatgccaaac acaaacactc 5701 ttgaaactct tcatagattt ggtgtggcta tgaattc (2) INFORMATION FOR SEQ ID NO:2531: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 5521 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2531: 1 cgaattcccc tatcacctaa gtgtgggcta atgtaacaaa gagggatttc acctacatcc 61 attcagtcag tctttggggg tttaaagaaa ttccaaagag tcatcagaag aggaaaaatg 121 aaggtaatgt tztttcagac tggtaaagtc tttgaaaata tgtgtaatat gtaaaacatt 181 ttgacacccc cataatattt ttccagaatt aacagtataa attgcatctc ttgttcaaga 241 gttccctatc actctttaat cactactcac agtaacctca actcctgcca caatgtacag 301 gatgcaactc ctgtcttgca ttgcactaag tcttgcactt gtcacaaaca gtgcacctac 361 ttcaagttct acaaagaaaa cacagctaca actggagcat ttactgctgg atttacagat 421 gattttgaat ggaattaatg taagtatatt tcctttctta ctaaaattat tacatttagt 481 aatctagctg gagatcattt cttaataaca atgcattata ctttcttaga attacaagaa 541 tcccaaactc accaggatgc tcacatttaa gttttacatg cccaagaagg taagtacaat 601 attttatgtt caatttctgt tttaataaaa ttcaaagtaa tatgaaaatt tgcacagatg 661 ggactaatag cagctcatct gaggtaaaga gtaactttaa tttgtttttt tgaaaaccca 721 agtttgataa gaagcctct attaaaacag ttttacctat atttttaata tatatttgtg WO 00/09525 PCTIUS99/17712 EPI-109 698 781 tgttggtggg ggtgggagaa aacataaaaa taatattctc tcactttatc gataagacaa 841 ttctaaacaa aaatgttcat ttatggtttc atttaaaaat gtaaaactct aaaatatttg 901 attatgtcat tttagtatgt aaaataccaa aatctatttc caaggagccc acttttaaaa 961 atcttttctt gttttaggaa aggtttctaa gtgagaggca gcataacact aatagcacag 1021 agtctggggc cagatatctq aagtgaaatc tcagctctgc catgtcctag ctttcatgat 1081 ctttggcaaa ttacctactc tgtttgtgat tcagtttcat gtctacttaa atgaataact 1141 gtatatactt aatatggctt tgtgagaatt agtaagtaaa tgtaaagcac tcagaaccgt 1201 gtctggcata aggtaaatac catacaagca ttagctatta ttagtagtat taaagataaa 1261 attttcactg agaaatacaa agtaaaattt tggactttat ctttttacca atagaacttg 1321 agatttataa tgctatatga cttattttcc aagattaaaa gcttcattag gttgtttttg 1381 gattcagata gagcataagc ataatcatcc aagctcctag gctacattag gtgtgtaaag 1441 ctacctagta gctgtgccag ttaagagaga atgaacaaaa tctgqtgcca gaaagagctt 1501 gtgccagggt gaatccaagc ccagaaaata ataggattta aggggacaca gatgcaatcc 1561 cattgactca aattctatta attcaagaga aatctgcttc taactaccct tctgaaagat 1621 gtaaaggaga cagcttacag atgttactct agtttaatca gagccacata atgcaactcc 1681 agcaacataa agatactaga tgctgttttc tgaagaaaat ttctccacat tgttcatgcc 1741 aaaaacttaa acccgaattt gtagaatttg tagtggtgaa ttgaaagcgc aatagatgga 1801 catatcaggg gattggtatt gtcttgacct acctttccca ctaaagagtg ttagaaagat 1861 gagattatgt gcataattta ggggtggtag aattcatgga aatctaagtt tgaaaccaaa 1921 agtaatgata aactctattc atttgttcat ttaaccctca ttgcacattt acaaaagatt 1981 ttagaaacta ataaaaatat ttgattccaa ggatgctatg ttaatgctat aatgagaaag 2041 aaatgaaatc taattctggc tctacctact tatgtggtca aattctgaga tttagtgtgc 2101 ttatttataa agtggagatg atacttcact gcctacttca aaagatgact gtgagaagta 2161 aatgggccta ttttggagaa aattctttta aattgtaata taccatagaa atatgaaata 2221 ttatatataa tatagaatca agaggcctgt ccaaaagtcc tcccaaagta ttataatctt 2281 ttatttcact gggacaaaca tttttaaaat gcatcttaat gtagtgattg tagaaaagta 2341 aaaatttaag acatatttaa aaatgtgtct tgctcaaggc tatattgaga gccactacta 2401 catgattatt gttacctagt gtaaaatgtt gggattgtga tagatggcat ccaagagttc 2461 cttctctctc aacattctgt gattcttaac tcttagacta tcaaatatta taatcataga 2521 atgtgatttt tatgccttcc acattctaat ctcatctggt tctaatgatt ttctatgcag 2581 attggaaaag taatcagcct acatctgtaa taggcattta gatgcagaaa gtctaacatt 2641 ttgcaaagcc aaattaagct aaaaccagtg agtcaactat cacttaacgc tagtcatagg 2701 tacttgagcc ctagtttttc cagttttata atgtaaactc tactggtcca tctttacagt 2761 gacattgaga acagagagaa tggtaaaaac tacatactgc tactccaaat aaaataaatt 2821 ggaaattaat ttctgattct gacctctatg taaactgagc tgatgataat tattattcta 2881 ggccacagaa ctgaaacatc ttcagtgtct agaagaagaa ctcaaacctc tggaggaagt 2941 gctaaattta gctcaaagca aaaactttca cttaagaccc agggacttaa tcagcaatat 3001 caacgtaata gttctggaac taaaggtaag gcattacttt atttgctctc ctggaaataa 3061 aaaaaaaaaa gtagggggaa aagtaccaca ttttaaagtg acataacatt tttggtattt 3121 gtaaagtacc catgcatgta attagcctac attttaagta cactgtgaac atgaatcatt 3181 tctaatgtta aatgattaac tggggagtat aagctactga gtttgcacct accatctact 3241 aatggacaag cctcatccca aactccatca cctttcatat taacacaaaa ctgggagtga 3301 gagagaagtg actgagttga gtttcacaga aacgcaggca agattttatt atatattttt 3361 caagttcctt cacagatcat ttactggaat agccaatact gagttacctg aaaggctttt 3421 caaatggtgt ttccttatca tttgatggaa ggactaccca taagagattt gtcttaaaaa 3481 aaaaaactgg agccattaaa atggccagtg gactaaacaa acaacaatct ttttagaggc 3541 aatcccactt tcagaatctt aagtattttt aaatgcacag gaagcataaa atatgcaagg 3601 gactcaggtg atgtaaaaga gattcacttt tgtcttttta tatcccgtct cctaaggtat 3661 aaaattcatg agttaatagg tatcctaaat aagcagcata agtatagtag taaaagacat 3721 tcctaaaagt aactccagtt gtgtccaaat gaatcactta ttagtggact gtttcagttg 3781 aattaaaaaa atacattgag atcaatgtca tctagacatt gacagattca gttccttatc 3841 tatggcaaga gttttactct aaaataatta acatcagaaa actcattctt aactcttgat 3901 acaaatttaa gacaaaacca tgcaaaaatc tgaaaactgt gtttcaaaag ccaaacactt 3961 tttaaaataa aaaaatccca agatatgaca atatttaaac aattatgctt aagaggatac 4021 agaacactgc aacagttttt taaaagagaa tacttattta aagggaacac tctatctcac 4081 ctgcttttgt tcccagggta ggaatcactt caaatttgaa aagctctctt ttaaatctca 4141 ctatatatca aaatagttgc ctccttagct tatcaactag aggaagcgtt taaatagctc 4201 ctttcagcag agaagcctaa tttctaaaaa gccagtccac agaacaaaat ttctaatgtt 4261 taaagctttt aaaagttggc aaattcacct gcattgatac tatgatgggg tagggatagg 4321 tgtaagtatt tatgaagatg ttcattcaca caaatttacc caaacaggaa gcatgtccta 4381 cctagcttac tctagtgtag ctcgtttcgt ctttggggaa aatataagga gattcactta 4441 agtagaaaaa taggagactc taatcaagat ttagaaaaga agaaagtata atgtgcatat 4501 caattcatac atttaactta cacaaatata ggtgtacatt cagaggaaaa gcgatcaagt 4561 ttatttcaca tccagcattt aatatttgtc tagatctatt tttatttaaa tctttatttg 4621 cacccaattt agggaaaaaa tttttgtgtt cattgactga attaacaaat gaggaaaatc 4681 tcagcttctg tgttactatc atttggtatc ataacaaaat acgcaatttt ggcattcatt 4741 ttgatcattt caagaaaatg tgaataatta atatgtttgg taagcttgaa aataaaggca 4801 acaggcctat aagacttcaa ttgggaataa ctgtatataa ggtaaactac tctgtacttt WO 00/09525 PCTIUS99/17712 EPI-109 699 4861 aaaaaattaa catttttrtt ttatagggat ctgaaacaac attcatgtgt gaatatgctg 4921 atgagacagc aaccattaa gaatttctga acagatggat taccttttgt caaagcatca 4981 tctcaacact gacttgataa ttaagtgctt cccacttaaa acatatcagg ccttctattt 5041 atttaaatat ttaaatttta tatttattgt tgaatgtatg gtttgctacc tattgtaact 5101 attattctta atcttaaaac tataaatatg gatcttttat gattcttttt gtaagcccta 5161 ggggctctaa aatggtttca cttatttatc ccaaaatatt tattattatg ttgaatgtta 5221 aatatagtat ctatgtagat tggttagtaa aactatttaa taaatttgat aaatataaac 5281 aagcctggat atttgttatt ttggaaacag cacagagtaa gcatttaaat atttcttagt 5341 tacttgtgtg aactgtagga tggttaaaat gcttacaaaa gtcactcttt ctctgaagaa 5401 atatgtagaa cagagatgta gacttctcaa aagcccttgc tttgtccttt caagggctga 5461 tcagaccctt agttctggca tctcttagca gattatattt tccttcttct taaaatgcca 5521 aacacaaaca ctcttgaaac tcttcataga tttggtgtgg c (2) INFORMATION FOR SEQ ID NO:2532: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 841 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2532: 1 ccccataata tttttccaga attaacagta taaattgcat ctcttgttca agagttccct 61 atcactctct ttaatcacta ctcacagtaa cctcaactcc tgccacaatg tacaggatgc 121 aactcctgtc ttgcattgca ctaagtcttg cacttgtcac aaacagtgca cctacttcaa 181 gttctacaaa gaaaacacag ctacaactgg agcatttact gctggattta cagatgattt 241 tgaatggaat taataattac aagaatccca aactcaccag gatgctcaca tttaagtttt 301 acatgcccaa gaaggccaca gaactgaaac atcttcagtg tctagaagaa gaactcaaac 361 ctctggagga agtgctaaat ttagctcaaa gcaaaaactt tcacttaaga cccagggact 421 taatcagcaa tatcaacgta atagttctgg aactaaaggg atctgaaaca acattcatgt 481 gtgaatatgc tgatgagaca gcaaccattg tagaatttct gaacagatgg attacctttt 541 gtcaaagcat catctcaaca ctgacttgat aattaagtgc ttcccactta aaacatatca 601 ggccttctat ttatttaaat atttaaattt tatatttatt qttgaatgta tggtttgcta 661 cctattgtaa ctattattct taatcttaaa actataaata tggatctttt atgattcttt 721 ttgtaagccc taggggctct aaaatggttt cacttattta tcccaaaata tttattatta 781 tgttgaatgt taaatatagt atctatgtag attggttagt aaaactattt aataaatttg 841 ataa (2) INFORMATION FOR SEQ ID NO:2533: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 22265 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2533: 1 cttcaactca ataagcattt taagtattct aatcttagta tttctctagc tgacatgtaa 61 gaagcaatct atcttattgt atgcaattag ctcattgtgt ggataaaaag gtaaaaccat 121 tctgaaacag gaaaccaata cacttcctgt ttaatcaaca aatctaaaca tttattcttt 181 tcatctgttt actcttgctc ttgtccacca caatatgcta ttcacatgtt cagtgtagtt 241 ttatgacaaa gaaaattttc tgagttactt ttgtatcccc acccccttaa agaaaggagg 301 aaaaactgtt tcatacagaa ggcgttaatt gcatgaatta gagctatcac ctaagtgtgg 361 gctaatgtaa caaagaggga tttcacctac atccattcag tcagtctttg ggggtttaaa 421 gaaattccaa agagtcatca gaagaggaaa aatgaaggca atgttttttc agacaggtaa 481 agtctttgaa aatatgtgta atatgtaaaa cattttgaca cccccataat atttttccag 541 aattaacagt ataaattgca tctcttgttc aagagctccc tatcactctc tttaatcact 601 actcacagta acctcaactc ctgccacaat gtacaggatg caactcctgt cttgcattgc 661 actaagtctt gcacttgtca caaacagtgc acctacttca agttctacaa agaaaacaca 721 gctacaactg gagcatttac ttctggattt acagatgatt ttgaatggaa ttaatgtaag 781 tatatttcct ttcttactaa aattattaca tttagtaatc tagctggaga tcatttctta 841 taacaatgca ttatactttc ttagaattac aagaatccca aactcaccag gatgctcaca 901 tttaagtttt acatgcccaa gaaggtaagt acaatatttt 1 gaattccctt ttcctagtca aagaaagggg tgacagacag cacctggaaa atcgtgtcac 61ttcccacccta atactgcgct tttccaatgg tcttagcaaa cagcacacca agagattata 121 tccagcacct ggctcagagg gtcctatgcc cacggagcct cactcactgc tagcacagca 181 gtctgagatc aaactgcaag gtggcagtga ggctgggaga ggggtgtgca ccattgccga 241 ggcttgagta ggtaaacaaa gcagctggga agctcgaact gggtggagcc cactgcagct 301 caaggaggcc tgcctgcctc tgtagactcc acctccgggg gcagggcata gccaaacaaa 361 aggcagcaga aacctctgca gacttaaatg tccctgtctg acagcttgga agagagtagt 421 ggttctccca gcatgcagct tgagatctga gaatggacag actgcctcct caagtgggtc 481 cctgaccccc gagtaaccta acagggaggc accccaagta ggggcagact gacacctcac 541 atggctgggt actcctctga gaaaaaactt ccagaggaac gacaggcag caacatttgc WO 00/09525 PCTIUS99/17712 EPI-109 700 601 tgttcaccaa ratccactgt tctgcagcct cctgtgctaa taCCCaUagCa aatgggtctg 661 gagaggacct ccagcaagct ccaacagacc tacagctgag ggtcctgact gttagaagga 721 aaactaacaa acagaaagga catccacacc aaaaccctat ctgtacggca ccatcatcaa 781 agaccaaagg tagataaaac cacaaagatg gggaaaaaaa cacagcagaa aaactggtaa 841 ctctaaaaat tagagcgctt ctcctcctcc aaaggaacgc agctcctcac cagcaatgga 901 accaagctgg acagagaatg actttgacga gttgagagaa gaaggcttca gatgatcaaa 961 ctactctgag ctaaaggagg aagttcgaac ccacggcaaa gaagtzaaaa accttgaaaa 1021 aaattagatg aatggctaac tagaataacc aatgcagaga agtccitaaa ggacctgatg 1081 gagctgaaaa ccatggcaca agaactacat gacaaatgca caagcctcag tagctgattc 1141 gatcaactgg aagaaagggt atcagtgatg gaagatcaaa tgaatgaaat gaagcaagaa 1201 gagaagttta gagaaaaaag aaaaaaaaga aatgaacaaa gcctccaaga aatatgggac 1261 tatgtgaaaa gaccaaatct acgtctgatt ggtgtacctg aaagtgatgg ggagaatgga 1321 accaagctgg aaaacactct gcaggatatt atccaagaga acttccccaa tctagcaagg 1381 caggctgaca ttcaaattca ggaaatacag agaacgccac aaatataatc ctcgagaaga 1441 gcaactccaa gacacataat tgttagattc actaaagttg aaatgaagga aaaaatgtta 1501 agggcagcca gagagaaagg tcagcttacc cacaaaggaa agcccatcag attaacagct 1561 gatctctcgg cagaaactct acaagccaga agagagtggg ggccaatatt caacattctt 1621 aaagaaaaga attttcaacc cagaatttca tatccagcca aactatgctt cataagtgaa 1681 ggagaaataa aatatagaca agtgaacgat gaaagatttt gtcaccacca ggcctgccct 1741 acaagagctc ctgaaggaag cactaaacat ggaaaggaac aaccggtacc agccactgca 1801 aaaacatgcc aaattgtaaa caccattgag gccaggaaga aactgcatca actaacgagc 1861 aaaataacca gctaacatca tcatgacagg atcaaattca cacataacaa tattaacctt 1921 aaatgtaaat aggctaaatg ctccaattaa aagacacaga ctggcaaact ggataaagag 1981 tcaagaccca tcagtgtgct gtattcagga aacccatctc acgtgcagag acacacatag 2041 gctcaaaata aagggatgga ggaagatcta ccaaacaaac ggaaaacaaa aaaaggcagg 2101 ggttgcaatc ctagtctctg ataaaacaga ctttaaacca acaaagatca aaagagacac 2161 agaaggccat tacataatgg taaagggatc aattcaacaa gaagagttaa ctatcctaaa 2221 tatatatgca cccaatacag gagcacctag attcataaag caagtcctta gagacctaca 2281 aagagactta gactcccaca caataataat gggagacttt aacaccccac tgtcaacatt 2341 agacagatca aigagacaga aaattaacaa ggatatccag gaattgaact caactctgca 2401 ccaagcggac ctaatagaca tctacagaac tctccacccc aaatcaacag aatatacatt 2461 cttttcggca ccacaccaca ccgattccaa aattgaacac atagttggaa gtaaagcact 2521 cctcagcaaa tgtaaaagaa cagaaagtac aacaaactgt ctctcagacc acagtgcaat 2581 caaactaaaa ctcaggatta agaaactcac tcaaaaccgc tcaactacat ggaaactgaa 2641 caacctgctc ctgaatgact actgggtaca taacgaaatg aaggcagaag taaagatgtt 2701 ctttgaaacc aacgagaaca aagacacaac ataccagaat ctctgggaca cattcaaagc 2761 agtgtgtaga ggaaaattta tagcactaaa tgcccacaag agaaagcagg aaagatctaa 2821 aattgacagc ctaacatcac aattaaaaga actagagaaa caagagcaaa cacattcaaa 2881 agctagcaga aggcaagaaa taactacaat cagagcagaa ctgaaggaga tagagacata 2941 caaaaaaccc ttcaaaaaat caatgaatcc aggagctggt tttttgaaaa gatcaacaaa 3001 attgatagac cactagcaaa actaatacag aagagagaag aatcaaatag acacaataaa 3061 aaatgataaa cgggatatca ccactgatcc cacagaaata caaactacca tcaaagaata 3121 ctataaacac ctctatgcaa ataaactaga aaatctagaa gaaatagata aattcctcga 3181 cacatacacc ctcccaagac taaaccagga agaagctgaa tctctgaata gaccaataac 3241 aggctctgaa artgaggcaa caattaacac cttaccaacc aataaaagtc caggaccaga 3301 tggattcaca gccaaattct accagaggta caaggaggag ctggtacgat tccttctgaa 3361 actattccaa tcaatagaaa aagagggaat cctccctaac tcattttatg aggccagcat 3421 catcctgata ccaaagcctg gcagagacac aacaaaaaaa gagaatttca gaccaatatc 3481 cctgatgaac arcgatgcaa aaatttttaa taaaatactg gcaaactgaa tccagcagca 3541 catcacaaag cttatccacc atgatcaagc tggcttcatt cctgggatgc aaggctggtt 3601 caacatacgg aaaatcaata aatgtaatcc agcatataaa cagaaccaac aacacacaac 3661 acatgattat ctcaacagat gcagaaaagg cctttgacaa aattcaacag cccttcatgc 3721 taaaaactct caataaatta ggtactgatg ggacgtatct caaaataata agcgctatct 3781 atgaccaacc cacagccaat atcatactgg atgggcaaaa actggaagca ttccctttga 3841 aaactggcac aagacaggga tgccctctct caccactcct attcaacaca gtgttcgaag 3901 ttctggcagg gcaatcaggc aggagaaaga aataaagggt attcaattag gaaaagagga 3961 ggtcaaattg tccctgtttg cagatgacat gattgtatat atagaaaacc ccattgtctc 4021 agcccaaaat ctccttaagc cgataagcaa cttcagcaaa gtctcaggat caaaatcaat 4081 gtgcaaaaat cacaagcatt cttatacacc aataacagac aaacagagag ccaaatcatg 4141.agtgaactcc cattcacaat tgcttcaaag agaataaaat acctaggaat ccaactcaca 4201 agggatgtga gagacctctt caaggagaac tataaaccac tgctcaatga aatgagagga 4261 tacagataaa tggaagaaca ttccatgctc atgggtagga agaatcaata tcgtgaaaat 4321 ggccatactg cccaaggtaa ttttatagat tcaatgccat ccccatcaag ctaccaatga 4381 ctttcttcac agaattggaa aaaactactt taaagttcat atggaaccaa aaaagagccc 4441 gcattgccaa gtcaatccta agccaaaaga acaaagctag aggcatcaca ctacctgact 4501 tcaaactata ctacaaggct acagtaacca aaacagcatg gtactagtac caaagcagag 4561 atatagacca arggaacaaa acagtgccct cagaaataat actgcaratc tacaaccatc 4621 tgatctttga caaacctgac aaaaacaagc aatggggaaa ggattcccta tttaataaat WO 00/09525 PCT/US99/17712 EPI-109 701 4681 ggtgctggga aaactggcta gccatatgta gaaagctgaa attggatccc ttccttacac 4741 cttgtacaaa aattaattca agatggatta cagacttaaa tgttagacct aaaaccataa 4801 aaaccctaga agaaaaccta ggcaatacca ttcaggacat aggcatgggc aagaacttca 4861 tgtctagaac accaaaagta atggcaacaa aagccaaaat tgacaaatgg gtctaattaa 4921 actaaagagc ttctgcacag caaaagaaac taccatcaga gtgaagaggc aacctacaga 4981 atgggagaaa atttttgcaa tctgacaaaa gggctaattt ttgcatctga caaagggcta 5041 atatccagaa tctacaatga actcaaacaa atttacaaga aaaaaacaaa tttacaagaa 5101 aaaaacaaaa tttacaagaa aaaaacaaat ttacaagaaa aaaacaaaca accccatcaa 5161 aaagtgggca aaggataaga acagtcactt ctcaaaagaa gacatttatg cagccaaaag 5221 acacatgaaa aaattctcat catcactggc catcagagaa atgcaaatca aaaccacaat 5281 gagataccat ctcacaccag ttagaatggc gatcattaaa aagtcaagaa acaacaggtg 5341 ctggagagga tgtggagaaa taggaacact tttacactgt tagtgggact gtaaactagt 5401 tcaacattgt ggaaatcagt atggcgattc ctcagggatc tagaactaga aataccattt 5461 gacccagcca tcccattact gggtatatac ccaaaggatt ataaatcatg ctgctataaa 5521 gacacttgca cacatatgtt tattgtggta ctattcacaa tagcaaagac ttggaattaa 5581 cccaaatgtc caacaatgat agactagatt aagaaaatgt ggcacatata cactatggaa 5641 tactttgcag ccataaaaaa ggatgagttc atgtcctttg tagggacatg gatgaagctg 5701 gaaaccatca ttctcggcaa actatcgcaa ggtcaaaaaa ccaaacaccg catgttctca 5761 ctcataggtg gtaactgaac aatgagaaca catggtcaca ggaaggggaa catcacgcac 5821 tggggcctgt tgtggggtgg ggggagtggg cagggatagc attaggagac atacctaatg 5881 ttaaatgacg atttaatggg tgcagcacac caacatggca catgtataca tatgtaacaa 5941 acccacacgt tgtgcacatg tactctaaaa cttaaagtat aattaaaata aataaataaa 6001 gtaaaaaaga aatcctaagg atactcaaat tgttgtttag gtgaagatgg atgatgcctt 6061 ccttgaatca tcagctacca ccgacagagt gaagtgagat ggaatagtgg gcacaatctc 6121 attcatccta ctctatgtag cctaatgggt ccagaattta tcatcactat tttacactgg 6181 aaaaaagatg agattatgag gggtcaggga ggctttgagt ttttgctcta acttcaccac 6241 taattaagaa tgtgatcttg ggtaagccac tttaacctct gtaaatgtca aatttcttat 6301 cagtaaaatg tgactataca agacaataaa tttgaaaata ctttgcaaaa ttgaaagtac 6361 catggaaata attcttcaat cccaaaaggt tatgaacatt attaaaattt gccacatgga 6421 agagcacaca cacagagac ataactgtga tcataaacag atttacaaaa gtggtgtttc 6481 attatggagg gccatagggc tgataaagac aaatgcatca ccaagctatg tccgagctca 6541 ttcagatttt tacaggaaac acagagcttc tagctgaatt atctctggat ggtgtggaaa 6601 ttgtccaaca cgttcctaat ttcaaagaaa cagaactgaa tcttgaaaac ccaagaggcc 6661 tttacagaaa ctgacaagag atgaattaat ataggtatca agctacagac caaattaaag 6721 ttttacaaaa ctttgaaaga gggtcagaaa gaagaaactt atgggaagca gagtcctgga 6781 aagtcagctt tgatggagtg acaatatgtg caacacagtg agcaatctct taggtaggca 6841 gcttcaggga tgggggttgc cctttgaaag gacttgggcc actcttgagt ctaagaggct 6901 aagtcacaaa caatgctaag caactaaaaa tagcttcttg tttaatagta aaattctgca 6961 tagtaaaagg agaagcaggg ggtatgacac acgtggtagt tagcagtcta ctagtgactt 7021 tactgccaca accagaaaag ccagctgatg tgtcagacgt gagaaagcga aagtatgtca 7081 cagcgaatgt agcttttcca cacgtatttc aagaaagaaa tgaaaaaggc caacttctat 7141 aatggtgcct actgtgcatt aacagagata aactaggggt ctaagaactc agttttctac 7201 agggtcccag aagtatagcc atatattgcc ccattctcta atggaaatag ccagagaaat 7261 agaaatatca agactggaga acatcaaata cctcattgga aaagccccca cataggaaaa 7321 tgtgtgggct tgaattcttc cattctggaa gggtaaaggc ctgagtgatg atgctgggat 7381 tagacactga aactctttag agaagcaaaa caagtataat aaagctgtac tttattatat 7441 taaataaata acacacagac taccaaatag cctgcccctt ataacagcgt taatgtgatt 7501 ttgatctgaa atgtatagag acattttgca ttttttcggt ataaaaagtt catgagattt 7561 ggccctaatc tggacctttt cttcattttt ttttctactt gagggactat aatctttatt 7621 tttaaatttg ttttatattc tccgaacatt accaacgca tagaaaactc ttcttgaacc 7681 atttttctct gttctttgta aaatattaca tttgactgtt ccttagactg ctttaatcat 7741 tcctgcctat gcaccctcct caaaatccag tttaaattaa ttgttcctta ttcaagattc 7801 cttatatcca cctcccttgg ggcagcaatc acctatcacc caggactaca cttgtgtatg 7861 tacatatctt ccctattaca aatcaggttc tttgaaaaaa tacaaatggt aagagagtgg 7921 atttttggag tcagtacatt ctcttttcaa atccttcttc tgccccttac tggcaataag 7981 ggctgagtga cctagagcaa attacttaac ttctctgagc ctcagttttc taatctgcaa 8041 aataggagcc atcacttcac aagtctgtaa gacttatatt agactaagtg cctgcctgta 8101 cactgttctc ttttctctct ttctatatac ctgaaggcat tataggtgct agatgtctgt 8161 ttaaagacca gacaatattg tcttaaaaaa acaaacaaaa acacagacaa taccatcttt 8221.aaaaaaaaaa aaaagtccag gtaagaaata aataaggcca tagaatggaa gctttacaag 8281 gactctctgt gagacaggat ctcctcaagct gtccccaggt taaattagaa gtatatatcc 8341 gtacaattgt tcagccagtt tgtgcactgt actgaggatg aatgaacacc tatcctaaat 8401 atcctagtct tctgactaaa aacaagatca tatttcataa cgattattgt tacattcata 8461 gtgtcccagg tgatttagag gataaataaa aatccattaa agaggtaaag acataaaaac 8521 gagaaacatg gactggttta cacataacac atacaaagtc tattataaaa ctagcatcag 8581 tatccttgaa tgcaaacctt tttctgagta tttaacaatc gcacccttta aaaaatgtac 8641 aatagacatt aagagactta aacagatata caatcatttt aaattaaaat agcgttaaac 8701 agtacctcaa gctcaataag catcttaagt attctaatct tagtatttct ctagctgaca WO 00/09525 PCT/US99/17712 EPI-109 702 8761 tgtaagaagc aatctatctt attgtatgca attagctcat tgtgtggata aaaaqgtaaa 8821 accattctga aacaggaaac caatacactt cctgtttaat caacaaatct aaacatttat 8881 tcttttcatc tgtttactct tgctgttgtc caccacaata tgctattcac atgttcagtg 8941 tagttttatg acaaagaaaa ttttctgagt tacttttgta tccccacccc cttaaagaaa 9001 ggaggaaaaa ctgtttcata cagaaggcgt taattgcatg aattagagct atcacctaag 9061 tgtgggctaa tgtaacaaag agggatttca cctacatcca ttcagtcagt ctttgggggt 9121 ttaaagaaat tccaaagagt catcagaaga ggaaaaatga aggtaatgtt ttttcagaca 9181 ggtaaagtct ttgaaaatat gtgtaatatg taaaacattt tgacaccccc ataatatttt 9241 tccagaatta acagtataaa ttgcatctct tgttcaagag ttccctatca ctctctttaa 9301 tcactactca cagtaacctc aactcctgcc acaatgtac 1 ttaatcaaca aatctaaaca tttattcttt tcatctgttt actcttgctc ttgttcacca 61 caatatgcta ttcacatgtt cagtgtagtt ttatgacaaa gaaaattttc tgagttactt 121 ttgtatcccc acccccttaa agaaaggagg aaaaactgtt tcatacagaa ggcgttaatt 181 gcatgaatta gagctatcac ctaagtgtgg gctaatgtaa caaagaggga tttcacctac 241 atccattcag tcagtctttg ggggtttaaa gaattccaaa gagtcatcag aagaggaaaa 301 atgaaggtaa tgttttttca gacaggtaaa gtctttgaaa atatgtgtaa tatgtaaaac 361 attttgacac ccccataata tttttccaga attaacagta taaattgcat ctcttgttca 421 agagttccct atcactctct ttaatcacta ctcacagtaa cctcaactcc tgccacaatg 481 tacaggatgc aactcctgtc ttgcattgca ctaagtcttg cacttgtcac aaacagtgca 541 cctacttcaa gttctacaaa gaaaacacag ctacaactgg agcatttact gctggattta 601 cagatgattt tgaatggaat taatgtaagt atatttcctt tcttactaaa attattacat 661 ttagtaatct agctggagat catttcttaa taacaatgca ttatactttc ttagaattac 721 aagaatccca aactcaccag gatgctcaca tttaagtttt acatgcccaa gaaggtaagt 781 acaatatttt atgttcaact tctgttttaa taaaattcaa agtaatatga aaatttgcac 841 agatgggact aatagcagct catctgaggt aaagagtaac tttaatttgt ttttttgaaa 901 acccaagttt gataatgaag cctctattaa aacagtttta cctatatttt taatatatat 961 ttgtgtgttg gtgggggtgg gaagaaaaca taaaaataat attctcacct ttatcgataa 1021 gacaattcta aacaaaaatg ttcatttatg gtttcattta aaaatgtaaa actctaaaat 1081 atttgattat gtcattttag tatgtaaaat accaaaatct atttccaagg agcccacttt 1141 taaaaatctt ttcttgtttt aggaaaggtt tctaagtgag aggcagcata acactaatag 1201 cacagagtct ggggccaqat atctgaagtg aaatctcagc tctgccatgt cctaqctttc 1261 atgatctttg gcaaattacc tactctgttt gtgattcagt ttcatgtcta cttaaatgaa 1321 taactgtata tacttaatat ggctttgtga gaattagtaa gttaaatgta aagcactcag 1381 aaccgtgtct ggcataaggt aaataccata caagcattag ctattattag tagtattaaa 1441 gataaaattt tcactgagaa atacaaagta aaattttgga ctttatcttt ttaccaatag 1501 aacttgagat ttataatgct atatgactta ttttccaaga ttaaaagctt cattaggttg 1561 tttttggatt cagatagagc ataagcataa tcatccaagc tcctaggcta cattaggtgt 1621 gtaaagctac ctagtagttg tgccagttaa gagagaatga acaaaatctg gtgccagaaa 1681 gagcttgtgc cagggtgaat ccaagcccag aaaataatag gatttaaggg gacacagatg 1741 caatcccatt gactcaaatt ctattaattc aagagaaatc tgcttctaac tacccttctg 1801 aaagatgtaa aggagacagc ttacagatgt tactctagtt taatcagagc cacataatgc 1861 aactccagca acataaagat actagatgct gttttctgaa gaaaatttct ccacattgtt 1921 catgccaaaa acttaaaccc gaatttgtag aatttgtagt ggtgaattga aagcgcaata 1981 gatggacata tcaggggatt ggtattgtct tgacctacct ttcccactaa agagtgttag 2041 aaagatgaga ttatgtgcat aatttagggg gtggtagaat tcatggaaat ctaagtttga 2101 aaccaaaagt aatgataaac tctattcatt tgttcattta accctcattg cacatttaca 2161 aaagatttta gaaactaata aaaatatttg attccaagga tgctatgtta atgctataat 2221 gagaaagaaa tgaaatctaa ttctggctct acctacttat gtggtcaaat tctgagattt 2281 agtgtgctta tttataaagt ggagatgata cttcactgcc tacttcaaaa gatgactgtg 2341 agaagtaaat gggcctattt tggagaaaat tcttttaaat tgtaatatac catagaaata 2401 tgaaatatta tatataatat agaatcaaga ggcctgtcca aaagtcctcc caaagtatta 2461 taatctttta tttcactggg acaaacattt ttaaaatgca tcttaatgta gtgattgtag 2521 aaaagtaaaa tttaagacat atttaaaaat gtgtcttgct caaggctata ttgagagcca 2581 ctactacatg attattgtta cctagtgtaa aatgttggga ttgtgataga tggcattcaa 2641 gagttccttc tctctcaaca ttctgtgatt cttaactctt agactatcaa atattataat 2701 catagaatgt gatttttatg cttccacatt ctaactcatc tggttctaat gattttctat 2761 gcagattgga aaagtaatca gcctgcatct gtgataggca cttacgatgc agaaagtcta 2821 acattttgca aagccaaatt aagctaaaac cagtgagtca actatcactt aacgctagtc 2881 ataggtactt gagccctagt ttttccagtt ttataatgta aactctactg gtccattctt 2941 tacagtgaca ttgagaacag agagaatggt aaaaactaca tactgctact ccaaataaaa 3001 taaattggaa attaatttct gattctgacc tctatgtaaa ctgagctgat gataattatt 3061 attctaggcc acagaactga aacatcttca gtgtctagaa gaagaactca aacctctgga 3121 ggaagtgcta aatttagctc aaagcaaaaa ctttcactta agacccaggg acttaatcag 3181 caatatcaac gtaatagttc tggaactaaa ggtaaggcat tactttattt gctctcctgg 3241 aaataaaaaa aaaaaagtca gggggaaaag taccacattt taaagtgaca taacattttt 3301 ggtatttgta aagtacccat gcatgtaatt agcctacatt ttaagtacac tgtgaacatg 3361 aatcatttct aatgttaaat gattaactgg ggagtataag ctactgagtt tgcacctacc 3421 atctactaat ggacaagcct catcccaaac tccatcacct ttcatattaa cacaaaactg WO 00/09525 PCT/US99/17712 EPI-109 703 3481 ggagtgagag aaggtactaa gttgagtttc acagaaagca ggcagazrtt attatatatt 3541 tttcgattct tcagatcazt tactgaaata gccaatactg attacczgaa aggcttttca 3601 aatggtgttt ccttatcatt tgatggaagg actacccata agagatttgt cttaaaaaaa 3661 aaaactggag ccattaaaat ggccagtgga ctaaacaaac aacaatcttt ttagaggcaa 3721 tccccacttt cagaatctta agtattttta aatgcacagg aagcataaaa tatgcaaggg 3781 actcaggtga tgtaaaagag attcactttt gtctttttat atcccgtctc ctaaggtata 3841 aaattcatga gttaataggt atcctaaata agcagcataa gtatagtagt aaaagacatt 3901 cctaaaagta actccagttg tgtccaaatg aatcacttat tagtggactg tttcagttga 3961 attaaaaaaa tacattgaga tcaatgtcat ctagacattg acagattcag ttccttatct 4021 atggcaagag ttttactcta aaataattaa catcagaaaa ctcattctta actcttgata 4081 caaatttaag acaaaaccat gcaaaaatct gaaaactgtg tttcaaaagc caaacacttt 4141 ttaaaataaa aaatcccaag atatgacaat atttaaacaa ttatgcttaa gaggatacag 4201 aacactgcaa cagtttttta aaagagaata cttatttaaa gggaacactc tatctcacct 4261 gcttttgttc ccagggtagg aatcacttca aatttgaaaa gctctctttt aaatctcact 4321 atatatcaaa atatttcctc cttagcttat caactagagg aagcgtttaa atagctcctt 4381 tcagcagaga agcctaattt ctaaaaagcc agtccacaga acaaaatttc taatgtttaa 4441 acttttaaaa gttggcaaat tcacctgcat tgatactatg atggggtagg gataggtgta 4501 agtatttaga agatgttctt cacacaaatt tatcccaaac ggaagcatgt cctagcttac 4561 tctagtgtag ttctgttctg ctttggggaa aatataagga gattcactta agtagaaaaa 4621 taggagactc taatcaagat ttagaaaaga agaaagtata atgtgcatat caattcatac 4681 atttaactta cacaaatata ggtgtacatt cagaggaaaa gcgatcaagt ttatttcaca 4741 tccagcattt aatatttgtc tagatctatt tttatttaaa tctttatttg cacccaattt 4801 agggaaaaaa tttttgtgtt cattgactga attaacaaat gaggaaaatc tcagcttctg 4861 tgttactatc atttggtatc ataacaaaat atgtaatttt ggcattcatt ttgatcattt 4921 caagaaaatg cgaataatta atatgtttgg taagcttgaa aataaaggca acaggcctat 4981 aagacttcaa ttgggaataa ctgtatataa ggtaaactac tctgtacttt aaaaaattaa 5041 catttttctt ttatagggat ctgaaacaac attcatgtgt gaatatgctg atgagacagc 5101 aaccattgta gaatttctga acagatggat taccttttgt caaagcatca tctcaacact 5161 gacttgataa ttaagtgctt cccacttaaa acatatcagg ccttctattt atttaaatat 5221 ttaaatttta tatttattgt tgaatgtatg gtttgctacc tattgtaact attattctta 5281 atcttaaaac tataaatatg gatcttttat gattcttttt gtgccctagg ggctctaaaa 5341 tggtttcact tatttatccc aaaatattta ttattatgtt gaatgttaaa tatagtgcta 5401 tgtagattgg ttagtaaaac tatttaataa atttgataaa tataaacaag cctggatatt 5461 tgttattttg gaaacagcac agagtaagca tttaaatatt tcttagttac ttgtgtgaac 5521 tgtaggatgg ttaaaatgct tacaaaagtc actctttctc tgaagaaata tgtagaacag 5581 agatgtagac ttctcaaaag cccttgcttt gtcctttcaa gggctgatca gacccttagt 5641 tctggcatct cttagcagat tatattttcc ttcttcttaa aatgccaaac acaaacactc 5701 ttgaaactct tcatagattt ggtgtggcta tgaattc 1 cgaattcccc tatcacctaa gtgtgggcta atgtaacaaa gagggatttc acctacatcc 61 attcagtcag tctttggggg tttaaagaaa ttccaaagag tcatcagaag aggaaaaatg 121 aaggtaatgt tttttcagac tggtaaagtc tttgaaaata tgtgtaatat gtaaaacatt 181 ttgacacccc cataatattt ttccagaatt aacagtataa attgcatctc ttgttcaaga 241 gttccctatc actctttaat cactactcac agtaacctca actcctgcca caatgtacag 301 gatgcaactc ctgtcttgca ttgcactaag tcttgcactt gtcacaaaca gtgcacctac 361 ttcaagttct acaaagaaaa cacagctaca actggagcat ttactgctgg atttacagat 421 gattttgaat ggaattaatg taagtatatt tcctttctta ctaaaattat tacatttagt 481 aatctagctg gagatcattt cttaataaca atgcattata ctttcttaga attacaagaa 541 tcccaaactc accaggatgc tcacatttaa gttttacatg cccaagaagg taagtacaat 601 attttatgtt caatttctgt tttaataaaa ttcaaagtaa tatgaaaatt tgcacagatg 661 ggactaatag cagctcatct gaggtaaaga gtaactttaa tttgtttttt tgaaaaccca 721 agtttgataa tgaagcctct attaaaacag ttttacctat atttttaata tatatttgtg 781 tgttggtggg ggtgggagaa aacataaaaa taatattctc tcactttatc gataagacaa 841 ttctaaacaa aaatgttcat ttatggtttc atttaaaaat gtaaaactct aaaatatttg 901 attatgtcat tttagtatgt aaaataccaa aatctatttc caaggagccc acttttaaaa 961 atcttttctt gttttaggaa aggtttctaa gtgagaggca gcataacact aatagcacag 1021 agtctggggc cagatatctg aagtgaaatc tcagctctgc catgtcctag ctttcatgat 1081 ctttggcaaa ttacctactc tgtttgtgat tcagtttcat gtctacttaa atgaataact 1141 gtatatactt aatatggctt tgtgagaatt agtaagtaaa tgtaaagcac tcagaaccgt 1201 gtctggcata aggtaaatac catacaagca ttagctatta ttagtagtat taaagataaa 1261 attttcactg agaaatacaa agtaaaattt tggactttat ctttttacca atagaacttg 1321 agatttataa tgctatatga cttattttcc aagattaaaa gcttcattag gttgtttttg 1381 gattcagata gagcataagc ataatcatcc aagctcctag gctacattag gtgtgtaaag 1441 ctacctagta gctgtgccag ttaagagaga atgaacaaaa tctggtgcca gaaagagctt 1501 gtgccagggt gaatccaagc ccagaaaata ataggattta aggggacaca gatgcaatcc 1561 cattgactca aattctatta attcaagaga aatctgcttc taactaccct tctgaaagat 1621 gtaaaggaga cagcttacag atgttactct agtttaatca gagccacata atgcaactcc 1681 agcaacataa agatactaga tgctgttttc tgaagaaaat ttctccacat tgttcatgcc 1741 aaaaacttaa acccgaactt gtagaatttg tagtggtgaa ttgaaagcgc aatagatgga WO 00/09525 PCT/US99/17712 EPI-109 704 1801 catatcaggg gattggtatt gtcttgacct acctttccca ctaaagagtg ttagaaagat 1861 gagattatgt gcataattta ggggtggtag aattcatgga aatctaagtt tgaaaccaaa 1921 agtaatgata aactctattc atttgttcat ttaaccctca ttgcacattt acaaaagatt 1981 ttagaaacta ataaaaatat ttgattccaa ggatgctatg ttaatgctat aatgagaaag 2041 aaatgaaatc taattctggc tctacctact tatgtggtca aattctgaga tttagtgtgc 2101 ttatttataa agtggagatg atacttcact gcctacttca aaagatgact gtgagaagta 2161 aatgggccta ttttggagaa aattctttta aattgtaata taccatagaa atatgaaata 2221 ttatatataa tatagaatca agaggcctgt ccaaaagtcc tcccaaagta ttataatctt 2281 ttatttcact gggacaaaca tttttaaaat gcatcttaat gtagtgattg tagaaaagta 2341 aaaatttaag acatatttaa aaatgtgtct tgctcaaggc tatattgaga gccactacta 2401 catgattatt gttacctagt gtaaaatgtt gggattgtga tagatagcat ccaagagttc 2461 cttctctctc aacattctgt gattcttaac tcttagacta tcaaatatta taatcataga 2521 atgtgatttt tatgccttcc acattctaat ctcatctggt tctaatgatt ttctatgcag 2581 attggaaaag taatcagcct acatctgtaa taggcattta gatgcagaaa gtctaacatt 2641 ttgcaaagcc aaattaagct aaaaccagtg agtcaactat cacttaacgc tagtcatagg 2701 tacttgagcc ctagtttttc cagttttata atgtaaactc tactggtcca tctttacagt 2761 gacattgaga acagagagaa tggtaaaaac tacatactgc tactccaaat aaaataaatt 2821 ggaaattaat ttctgattct gacctctatg taaactgagc tgatgataat tattattcta 2881 ggccacagaa ctgaaacatc ttcagtgtct agaagaagaa ctcaaacctc tggaggaagt 2941 gctaaattta gctcaaagca aaaactttca cttaagaccc agggacttaa tcagcaatat 3001 caacgtaata gttctggaac taaaggtaag gcattacttt atttgctctc ctggaaataa 3061 aaaaaaaaaa gtagggggaa aagtaccaca ttttaaagtg acataacatt tttggtattt 3121 gtaaagtacc catgcatgta attagcctac attttaagta cactgtgaac atgaatcatt 3181 tctaatgtta aatgattaac tggggagtat aagctactga gtttgcacct accatctact 3241 aatggacaag cctcatccca aactccatca cctttcatat taacacaaaa ctgggagtga 3301 gagagaagtg actgagttga gtttcacaga aacgcaggca agattttatt atatattttt 3361 caagttcctt cacagatcat ttactggaat aqccaatact gagttacctg aaaggctttt 3421 caaatggtgt ttccttatca tttgatggaa ggactaccca taagagattt gtcttaaaaa 3481 aaaaaactgg agccattaaa atggccagtg gactaaacaa acaacaatct ttttagaggc 3541 aatcccactt tcagaatctt aagtattttt aaatgcacag gaagcataaa atatgcaagg 3601 gactcaggtg atgtaaaaga gattcacttt tgtcttttta tatcccgtct cctaaggtat 3661 aaaattcatg agttaatagg tatcctaaat aagcagcata agtatagtag taaaagacat 3721 tcctaaaagt aactccagtt gtgtccaaat gaatcactta ttagtggact gtttcagttg 3781 aattaaaaaa atacattgag atcaatgtca tctagacatt gacagattca gttccttatc 3841 tatggcaaga gttttactct aaaataatta acatcagaaa actcattctt aactcttgat 3901 acaaatttaa gacaaaacca tgcaaaaatc tgaaaactgt gtttcaaaag ccaaacactt 3961 tttaaaataa aaaaatccca agatatgaca atatttaaac aattatgctt aagaggatac 4021 agaacactgc aacagttttt taaaagagaa tacttattta aagggaacac tctatctcac 4081 ctgcttttgt tcccagggta ggaatcactt caaatttgaa aagctctctt ttaaatctca 4141 ctatatatca aaatagttgc ctccttagct tatcaactag aggaagcgtt taaatagctc 4201 ctttcagcag agaagcctaa tttctaaaaa gccagtccac agaacaaaat ttctaatgtt 4261 taaagctttt aaaagttggc aaattcacct gcattgatac tatgatgggg tagggatagg 4321 tgtaagtatt tatgaagatg ttcattcaca caaatttacc caaacaggaa gcatgtccta 4381 cctagcttac tctagtgtag ctcgtttcgt ctttggggaa aatataagga gattcactta 4441 agtagaaaaa taggagactc taatcaagat ttagaaaaga agaaagtata atgtgcatat 4501 caattcatac atttaactta cacaaatata ggtgtacatt cagaggaaaa gcgatcaagt 4561 ttatttcaca tccagcattt aatatttgtc tagatctatt tttatttaaa tctttatttg 4621 cacccaattt agggaaaaaa tttttgtgtt cattgactga attaacaaat gaggaaaatc 4681 tcagcttctg tgttactatc atttggtatc ataacaaaat acgcaatttt ggcattcatt 4741 ttgatcattt caagaaaatg tgaataatta atatgtttgg taagcttgaa aataaaggca 4801 acaggcctat aagacttcaa ttgggaataa ctgtatataa ggtaaactac tctgtacttt 4861 aaaaaattaa catttttctt ttatagggat ctgaaacaac attcatgtgt gaatatgctg 4921 atgagacagc aaccattgta gaatttctga acagatggat taccttttgt caaagcatca 4981 tctcaacact gacttgataa ttaagtgctt cccacttaaa acatatcagg ccttctattt 5041 atttaaatat ttaaatttta tatttattgt tgaatgtatg gtttgctacc tattgtaact 5101 attattctta atcttaaaac tataaatatg gatcttttat gattcttttt gtaagcccta 5161 ggggctctaa aatggtttca cttatttatc ccaaaatatt tattattatg ttgaatgtta 5221 aatatagtat ctatgtagat tggttagtaa aactatttaa taaatttgat aaatataaac 5281 aagcctggat atttgttatt ttggaaacag cacagagtaa gcatttaaat atttcttagt 5341 tacttgtgtg aactgtagga tggttaaaat gcttacaaaa gtcactcttt ctctgaagaa 5401 atatgtagaa cagagatgta gacttctcaa aagcccttgc tttgtccttt caagggctga 5461 tcagaccctt agttctggca tctcttagca gattatattt tccttcttct taaaatgcca 5521 aacacaaaca ctcttgaaac tcttcataga tttggtgtgg c 1 ccccataata tttttccaga attaacagta taaattgcat ctcttgttca agagttccct 61 atcactctct ttaatcacta ctcacagtaa cctcaactcc tgccacaatg tacaggatgc 121 aactcctgtc ttgcattgca ctaagtcttg cacttgtcac aaacagtgca cctacttcaa 181 gttctacaaa aaaaacacag ctacaactgg agcatttact gctggattta cagatgattt 241 tgaatggaat -aataattac aagaatccca aactcaccag gatgctcaca tttaagtttt WO 00/09525 PCTIUS99/17712 EPI-109 705 301 acatgcccaa gaaggccaca gaactgaaac atcttcagtg tctagaagaa gaactcaaac 361 ctctggagga agtgctaaat ttagctcaaa gcaaaaactt tcacttaaga cccagggact 421 taatcagcaa tatcaacgta atagttctgg aactaaaggg atctgaaaca acattcatgt 481 gtgaatatgc zgatgagaca gcaaccattg tagaatttct gaacagatgg attacctttt 541 gtcaaagcat catctcaaca ctgacttgat aattaagtgc ttcccactta aaacatatca 601 ggccttctat ttatttaaat atttaaattt tatatttatt gttgaatgta tggtttgcta 661 cctattgtaa ctattattct taatcttaaa actataaata tggatctttt atgattcttt 721 ttgtaagccc taggggctct aaaatggttt cacttattta tcccaaaata tttattatta 781 tgttgaatgt :aaatatagt atctatgtag attggttagt aaaactattt aataaatttg 841 ataa (2) INFORMATION FOR SEQ ID NO:2534: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 901 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2534: 1 aggcccagtt gaaaccaggg agttgctctc ctttctcctc ccttgacctc acccctcaga 61 ccatgccaat tctgcctcct aaacctccca ggccagcccc tcccccagct cccagtgaca 121 gtgtcctcag gtacctgagc tcagctctcg gtgctaccag agggactgca gggctgcaga 181 ggctgagtcc cacacgcagg gaacagccat gccactgcta gcagaccagt aagagaatgg 241 ccacctgggg cctgagcgcc ctcggccatc caccagaaac aaagtgtcaa ggagaagctg 301 cccgaagccc atgggacaaa ccactgggga ctggaacacc agtaattctg tattgggaag 361 cggcaccaaa agatgtgctt ctcagagcct gaggctgaac gtggatgttt agcagcgtga 421 ccggctacca gacaaactct catctgttcc agtggcctcc tggccaccca ccaggaccaa 481 gcagggcggg cagcagaggg ccagggtagt ccaggtgatg gcagatgaga tcccactggg 541 caggaggcct cagtgagctg agtcaggctt ccccttcctg ccacaggggt cctctcacct 601 gctgccatgc ttcccatctc tcatcctcct tgacaagatg aagtgatacc gtttaagtaa 661 tcttttttct tgtttcactg atcttgagta ctagaaagtc atggatgaat aattacgtct 721 gtggttttct atggaggttc catgtcagat aaagatcctt ccgacgcctg ccccacacca 781 ccacctcccc cgccttgccc ggggttgtgg gcaccttgct gctgcacata taaggcggga 841 gctgttgcca actcttcaga gccccacgaa ggaccagaac aagacagagt gcctcctgcc 901 gatccaaaca tgagccgcc (2) INFORMATION FOR SEQ ID NO:2535: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 421 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2535: 1 gccacccacc aggaccaagc agggcgggca gcagagggcc agggtagtcc aggtgatggc 61 agatgagatc ccactgggca ggaggcctca gtgagctgag tcaggcttcc ccttcctgcc 121 acaggggtcc tctcacccgc tgccatgctt cccatctctc atcctccttg acaagatgaa 181 gtgataccgt ttaagtaatc ttttttcttg tttcactgat cttgagtact agaaagtcat 241 ggatgaataa ttacgtctgt ggttttctat ggaggttcca tgtcagataa agatccttcc 301 gacgcctgcc ccacaccacc acctcccccc gccttgcccg gggttgtggg caccttgctg 361 ctgcacatat aaggcgggag gttgttgcca actcttcaga gccccacgaa ggaccagaac 421 aagacagagt gcctcctgcc gatccaaaca tg (2) INFORMATION FOR SEQ ID NO:2536: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 2701 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2536: 1 gatccaggag accagtctcc tagtaccagg tctgcttgcc taaacttgga gtataagagc 61 catagacact gtctcttcga tcagtccttg cccccacccc ctgctgttgc acccttatct 121ttcaccctac tgctcctgca ttgaagacag aagcacccag tttcccctgc ctcagcataa 181 cttgctagcc ttcatttcct cgtgctggtc acatcacacc acaacccgac ccaaaccctg 241 gtttctctac catgcccctg cttccctgca ccccaggctt gtcacactca tcttctacca 301 aaactccagc tttgtgctgt ggcctgtcaa cctgtcccat ggaaaagggg gccaccccat 361 ccttcaggga ctgtcccctg gctctccaca ctcctggctt tgccactttc tctctagctg 421 tggtttctca ggtcctttga gaacttccca taactgtccc tgtttccttc ccacctctgt 481 aggcctgagc tgcaaaccag ctcccactcc acccaggctc cagggccgac tgggatttag 541 atccctcaat atggcttcc ttcagggagt agttctcttc tctcctcttg ccctcccggc 601 tcaaacttgt ccatgccacc tgctacaccg tcctgcagct cccagtaact aacactattc WO 00/09525 PCT/US99/17712 EPI-109 706 661 tcaaggccca cctttgtccc taggtcccta agcctaatta tctgagttat cagaaggatg 721 gcctagtgtt tgcagtcata tctccatcaa gggttctgtc ctctagatgt gggccttagc 781 gcattgcctt actgcactga gactagacca gtgaaggagt gagctgaact ccatatccac 841 ctgcaaggaa taagggtcaa tgggaaggct gcctagaggg agagggagct ctagctacca 901 gcggccagag gactagccca cccatggacg tttaaccatg tgccagaatg cctaccatgt 961 tcaagtttgc cccagtgacc ctggtggccc actaatagtg gtggcccaca gtcaggggca 1021 gatttgtaca agggatggta ggaagaggtt ccagtgcaca gaaaccccaa gctggctcgg 1081 agccaggcta cttcctccca ccacctgttt ccactcggtc catctctatg acaaaggaag 1141 aagatggcct ttgaataagc agtctttctt cccatgtcga taattttgag tactagaaaa 1201 cgatgaataa gtctgtggtt tgctatggag gttccatgtc agataaagct gcttctgatg 1261 cctgcccttc cccccatgcc ctgcctgggg cccgccccgc ccctctcgat gaatatatat 1321 aaggtgaagg ctcctgtggc ttcttcagaa ctctttggag gaccagaacg agacaatggt 1381 tcttgccagc tctaccacca gcatcctctg tatgctgctc ccgctcctga tgctcttcca 1441 ccagggactc cagatttcag acaggggctc agatgcccac catttactca ggacgttgga 1501 ttgcaggact attgccttgg agattttggt gaagctccca gtgagtagct ggctgaggtt 1561 agcctgggca ggctggcttc aacaggtgcc tcggaccaat aagcctcatg attctttctt 1621 ttagtatcct caggtatctg gactcaataa tagtgacgac aaagccaatc tgagggtaag 1681 agccctgctc ttgggcatt 'c ttgggttcca tctgtctcct gcctgggtga ctttagccat 1741 gtcactgcac cctgctttgc ttccgttttc acatctatct cagtggggtt attaaggaaa 1801 tcatcagatg actctctgag cctcagtctg tgccacagcc agctgcaata atgaaagttg 1861 cattttagga gatacaatgg agagagaact gtgagtgaac cctgccacag gcctctggct 1921 ccactttcag tggggatgcc atggggatgc catggaccag tgaacgagtt gccttctgtg 1981 actgtgtctt ttgcttttct tcctcctcca aaactgagct tgtgttctcc acttccacca 2041 gcctaagaca ttaccatttg cagttatttt cccagctcta gttagataca atggttctgt 2101 ttcgttttta tttgtttgca agcgtgctga gtgtctacgt ttcccctccc tagggacatg 2161 atgaagtctg taggattttc ttctagatat ctagaagttc ttaattaaat taaagcattg 2221 gggttgggga tttagctcag tggtagagtg cttgcctagc aagcgcaagg ccctgagttc 2281 attccccagc tccgaaaaaa agaaaaaaga aaaagaaaaa aaattaaagc attaaccttg 2341 gtgtttggca tcttgggcat aagtatttcc cttggccaac cttctgcctt ttctagagct 2401 tgtctggaga gatatgtttc ccttaaaaac agacagatct gcttagagcc ttcacacagt 2461 ccacaggctg ccaggggtta agacctggtg ctcaggagaa acaggccctt gtctgggatg 2521 tgccctagct ttagccccag gataaggaaa ggaccaggag taaggctgtt caaagaaacc 2581 tctaacagca gtcacacctc cccagctctc acctccccag ctctcacctc cccagctctc 2641 acctctcccg ctctcacctc cccagctctc acctctccag ctctcacttc cccagttctc 2701 acctccccag ctctcacctc tccagctctc acctccccag ctctcacct (2) INFORMATION FOR SEQ ID NO:2537: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 901 base pairs (B) TYPE: nucleic acid (C) STRAI4DEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2537: 1 cagagcccca cgaaggacca gaacaagaca gagtgcccc tgccgatcca aacatgagcc 61 gcctgcccgt cctgctcctg ctccaactcc tggtccgccc cggactccaa gctcccatga 121 cccagacaac gcccttgaag acaagctggg ttaactgctc taacatgatc gatgaaatta 181 taacacactt aaagcagcca cctttgcctt tgctggactt caacaacctc aatggggaag 241 accaagacat tctgatggaa aataaccttc gaaggccaaa cctggaggca ttcaacaggg 301 ctgtcaagag tttacagaac gcatcagcaa ttgagagcat tcttaaaaat ctcctgccat 361 gtctgcccct ggccacggcc gcacccacgc gacatccaat ccatatcaag gacggtgact 421 ggaatgaatt ccggaggaaa ctgacgttct atctgaaaac ccttgagaat gcgcaggctc 481 aacagacgac tttgagcctc gcgatctttt agtccaacgt ccagctcgtt ctctgggcct 541 tctcaccaca gagcctcggg acatcaaaaa cagcagaact tctgaaacct ctgggtcatc 601 tctcacacat tccaggacca gaagcatttc accttttcct gcggcatcag atgaattgtt 661 aattatctaa tttctgaaat gtgcagctcc catttggcct tgtgcggttg tgttctcatt 721 tttatcccat tgagactatt tatttatgta tgtatgtatt tatttattta ttgcctggag 781 tgtgaactgt atttatttta gcagaggagc catgtcctgc tgcttctgca aaaaactcag 841 agtggggtgg ggagcatgtt catttgtacc tcgagtttta aactggttcc tagggatgtg 901 tgagaataaa ctagactctg aac (2) INFORMATION FOR SEQ ID NO:2538: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 841 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2538: 1 tgtgtaagta agtgcaagct acagagaaaa ccaaggaaga aaaaaattgc cagagatcca 61 ggttaaaaaa aaaaaaagaa aaagaaaaga aaaccaagga agcaatcatc ataaaagaca WO 00/09525 PCT/US99/17712 EPI-109 707 121 ggtgagtggg ttacctctaa gggcgagcag tcacgattag aggacaaata tggggagagt 181 tttggagcgt tggcgatttt tttttgactt aagcatggtt aaatgggtga ttgcttataa 241 ttacttgtta aattaggtta attaggtttt atttacatgt tttatgctct tttctgcatg 301 catttgtgct ctattttttt aattaaaaaa taaaataaag taaaactatg tttcttgcac 361 ttaaaatact ggaaaaccaa agagaatctg aaaaactttt agaatgaaga gagtttgaca 421 agacggcaag aacccttgct ttttccactg ggcctttctt cctcccaccc tgagggtgct 481 ccatggaaaa tgcaaatcta cttaactgac tttcgcaaat gtcaaatgta gagtacgaat 541 ttcaagggga gcctggggct gtgccatatc ctgctgtgag ctacagtttt ccagcctcta 601 gagccatctt aacaaggtgc ctgcctggtg tctactaccc cagtatgtgc tccaacccct 661 gcccaggcct cctagtgcta gagaggatat agacatggcc tctccatgga aacctccagg 721 gctggtatga caccttaaca aacaaaaagg gaggattgcc ggtacagcgg agtcccgcag 781 gaggataggt gttgccttct aggtggtagg gaggctgaga gggccatcca gagtagggac 841 cacgaactgg ggtctcaaca tgaagagtcg ttcatcagat ct (2) INFORMATION FOR SEQ ID NO:2539: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 2581 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2539: 1 aggcccagtt gaaaccaggg agttgctctc ctttctcctc ccttgacctc acccctcaga 61 ccatgccaat tctgcctcct aaacctccca ggccagcccc tcccccagct cccagtgaca 121 gtgtcctcag gtacctgagc tcagctctcg gtgctaccag agggactgca gggctgcaga 181 ggctgagtcc cacacgcagg gaacagccat gccactgcta gcagaccagt aagagaatgg 241 ccacctgggg cctgagcgcc ctcggccatc caccagaaac aaagtgtcaa ggagaagctg 301 cccgaagccc atgggacaaa ccactgggga ctggaacacc agtaattctg tattgggaag 361 cggcaccaag agatgtgctt ctcagagcct gaggctgaac gtggatgttt agcagcgtga 421 ccggctacca gacaaactct catctgttcc agtggcctcc tggccaccca ccaggaccaa 481 gcagggcggg cagcagaggg ccagggtagt ccaggtgatg gcagatgaga tcccactggg 541 caggaggcct cagtgagctg agtcaggctt ccccttcctg ccacaggggt cctctcacct 601 gctgccatgc ttcccatctc tcatcctcct tgacaagatg aagtgatacc gtttaagtaa 661 tcttttttct tgtttcactg atcttgagta ctagaaagtc atggatgaat aattacgtct 721 gtggttttct atggaggttc catgtcagat aaagatcctt ccgacgcctg ccccacacca 781 ccacctcccc cgccttgccc ggggttgtgg gcaccttgct gctgcacata taaggcggga 841 gctgttgcca actcttcaga gccccacgaa ggaccagaac aagacagagt gcctcctgcc 901 gatccaaaca tgagccgcc 1 gccacccacc aggaccaagc agggcgggca gcagagggcc agggtagtcc aggtgatggc 61 agatgagatc ccactgggca ggaggcctca gtgagctgag tcaggcttcc ccttcctgcc 121 acaggggtcc tctcacctgc tgccatgctt cccatctctc atcctccttg acaagatgaa 181 gtgataccgt ttaagtaatc ttttttcttg tttcactgat cttgagtact agaaagtcat 241 ggatgaataa ttacgtctgt ggttttctat ggaggttcca tgtcagataa agatccttcc 301 gacgcctgcc ccacaccacc acctcccccc gccttgcccg gggttgtggg caccttgctg 361 ctgcacatat aaggcgggag gttgttgcca actcttcaga gccccacgaa ggaccagaac 421 aagacagagt gcctcctgcc gatccaaaca tg 1 gatccaggag accagtctcc tagtaccagg tctgcttgcc taaacttgga gtataagagc 61 catagacact gtctcttcga tcagtccttg cccccacccc ctgctgttgc acccttatct 121 ttcaccctat tgctcctgca ttgaagacag aagcacccag tttcccctgc ctcagcataa 181 cttgctagcc ttcatttcct cgtgctggtc acatcacacc acaacccgac ccaaaccctg 241 gtttctctac catgcccctg cttccctgca ccccaggctt gtcacactca tcttctacca 301 aaactccagc tttgtgctgt ggcctgtcaa cctgtcccat ggaaaagggg gccaccccat 361 ccttcaggga ctgtcccctg gctctccaca ctcctggctt tgccactttc tctctagctg 421 tggtttctca ggtcctttga gaacttccca taactgtccc tgtttccttc ccacctctgt 481 aggcctgagc tgcaaaccag ctcccactcc acccaggctc cagggccgac tgggatttag 541 atccctcaat atggctttcc ttcagggagt agttctcttc tctcctcttg ccctcccggc 601 tcaaacttgt ccatgccacc tgctacaccg tcctgcagct cccagtaact aacactattc 661 tcaaggccca cctttgtccc taggtcccta agcctaatta tctgagttat cagaaggatg 721 gcctagtgtt tgcagtcata tctccatcaa gggttctgtc ctctagatgt gggccttagc 781 gcattgcctt actgcactga gactagacca gtgaaggagt gagctgaact ccatatccac 841 ctgcaaggaa taagggtcaa tgggaaggct gcctagaggg agagggagct ctagctacca 901 gcggccagag gactagccca cccatggacg tttaaccatg tgccagaatg cctaccatgt 961 tcaagtttgc cccagtgacc ctggtggccc actaatagtg gtggcccaca gtcaggggca 1021 gatttgtaca agggatggta ggaagaggtt ccagtgcaca gaaaccccaa gctggctcgg 1081 agccaggcta cttcctccca ccacctgttt ccactcggtc catctctatg acaaaggaag 1141 aagatggcct ttgaataagc agtctttctt cccatgtcga taattttgag tactagaaaa 1201 cgatgaataa gtctgtggtt tgctatggag gttccatgtc agataaagct gcttctgatg 1261 cctgcccttc cccccatgcc ctgcctgggg cccgccccgc ccctctcgat gaatatatat 1321 aaggtgaagg ctcctgtggc ttcttcagaa ctctttggag gaccagaacg agacaatggt 1381 tcttgccagc tctaccacca gcacctctg tatgctgctc ccgctcctga tgctcttcca WO 00/09525 PCT/US99/17712 EPI-109 708 1441 ccagggaczc cagatttcag acaggggctc agatgcccac catttactca ggacgttgga 1501 ttgcaggact aztgccttgg agattttggt gaagctccca gtgagzagct ggctgaggtt 1561 agcctgggca ggctggcttc aacaggtgcc tcggaccaat aagcctcatg attctttctt 1621 ttagtatcct caggtatctg gactcaataa tagtgacgac aaagccaatc tgagggtaag 1681 agccctgctc ttgggcattc ttgggttcca tctgtctcct gcctgggtga ctttagccat 1741 gtcactgcac cctgctttgc ttccgttttc acatctatct cagtggggtt attaaggaaa 1801 tcatcagatg actctctgag cctcagtctg tgccacagcc agctgcaata atgaaagttg 1861 cattttagga gatacaatgg agagagaact gtgagtgaac cctgccacag gcctctggct 1921 ccactttcag tggggatgcc atggggatgc catggaccag tgaacgagtt gccttctgtg 1981 actgtgtctt ttgcttttct tcctcctcca aaactgagct tgtgttctcc acttccacca 2041 gcctaagaca ttaccatttg cagttatttt cccagctcta gttagataca atggttctgt 2101 ttcgttttta tttgtttgca agcgtgctga gtgtctacgt ttcccctccc tagggacatg 2161 atgaagtctg taggattttc ttctagatat ctagaagttc ttaattaaat taaagcattg 2221 gggttgggga tttagctcag tggtagagtg cttgcctagc aagcgcaagg ccctgagttc 2281 attccccagc tccgaaaaaa agaaaaaaga aaaagaaaaa aaattaaagc attaaccttg 2341 gtgtttggca tcttgggcat aagtatttcc cttggccaac cttctgcctt ttctagagct 2401 tgtctggaga gatatgtttc ccttaaaaac agacagatct gcttagagcc ttcacacagt 2461 ccacaggctg ccaggggtta agacctggtg ctcaggagaa acaggccctt gtctgggatg 2521 tgccctagct ttagccccag gataaggaaa ggaccaggag taaggctgtt caaagaaacc 2581 tctaacagca gtcacacctc cccagctctc acctccccag ctctcacctc cccagctctc 2641 acctctcccg ctctcacctc cccagctctc acctctccag ctctcacttc cccagttctc 2701 acctccccag ctctcacctc tccagctctc acctccccag ctctcacct 1 cagagcccca cgaaggacca gaacaagaca gagtgcctcc tgccgatcca aacatgagcc 61 gcctgcccgt cctgctcctg ctccaactcc tggtccgccc cggactccaa gctcccatga 121 cccagacaac gcccttgaag acaagctggg ttaactgctc taacatgatc gatgaaatta 181 taacacactt aaagcagcca cctttgcctt tgctggactt caacaacctc aatggggaag 241 accaagacat tctgatggaa aataaccttc gaaggccaaa cctggaggca ttcaacaggg 301 ctgtcaagag tttacagaac gcatcagcaa ttgagagcat tcttaaaaat ctcctgccat 361 gtctgcccct ggccacggcc gcacccacgc gacatccaat ccatatcaag gacggtgact 421 ggaatgaatt ccggaggaaa ctgacgttct atctgaaaac ccttgagaat gcgcaggctc 481 aacagacgac tttgagcctc gcgatctttt agtccaacgt ccagctcgtt ctctgggcct 541 tctcaccaca gagcctcggg acatcaaaaa cagcagaact tctgaaacct ctgggtcatc 601 tctcacacat tccaggacca gaagcatttc accttttcct gcggcatcag atgaattgtt 661 aattatctaa tttctgaaat gtgcagctcc catttggcct tgtgcggttg tgttctcatt 721 tttatcccat tgagactatt tatttatgta tgtatgtatt tatttattta ttgcctggag 781 tgtgaactgt atttatttta gcagaggagc catgtcctgc tgcttctgca aaaaactcag 841 agtggggtgg ggagcatgtt catttgtacc tcgagtttta aactggttcc tagggatgtg 901 tgagaataaa ctagactctg aac 1 tgtgtaagta agtgcaagct acagagaaaa ccaaggaaga aaaaaattgc cagagatcca 61 ggttaaaaaa aaaaaaagaa aaagaaaaga aaaccaagga agcaatcatc ataaaagaca 121 ggtgagtggg ttacctctaa gggcgagcag tcacgattag aggacaaata tggggagagt 181 tttggagcgt tggcgatttt tttttgactt aagcatggtt aaatgggtga ttgcttataa 241 ttacttgtta aattaggtta attaggtttt atttacatgt tttatgctct tttctgcatg 301 catttgtgct ctattttttt aattaaaaaa taaaataaag taaaactatg tttcttgcac 361 ttaaaatact ggaaaaccaa agagaatctg aaaaactttt agaatgaaga gagtttggca 421 agacggcaag aacccttgct ttttccactg ggcctttctt cctcccaccc tgagggtgct 481 ccatggaaaa tgcaaatcta cttaactgac tttcgcaaat gtcaaatgta gagtacgaat 541 ttcaagggga gcctggggct gtgccatatc ctgctgtgag ctacagtttt ccagcctcta 601 gagccatctt aacaaggtgc ctgcctggtg tctactaccc cagtatgtgc tccaacccct 661 gcccaggcct cctagtgcta gagaggatat agacatggcc tctccatgga aacctccagg 721 gctggtatga caccttaaca aacaaaaagg gaggattgcc ggtacagcgg agtcccgcag 781 gaggataggt gttgccttct aggtggtagg gaggctgaga gggccatcca gagtagggac 841 cacgaactgg ggtctcaaca tgaagagtcg ttcatcagat ct (2) INFORMATION FOR SEQ ID NO:2540: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1441 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2540: 1 gcacacggga agatatcaga aacatcctag gatcaggaca ccccagatct tctcaactgg 61 aaccacgaag gctgtttctt ccacacagca ctttgatctc catttaagca ggcacctctg 121 tcctgcgttc cggagctgcg ttcccgatgg tcctcctttg gctcacgctg ctcctgatcg 181 ccctgccctg tctcctgcaa acgaaggaag atccaaaccc accaatcacg aacctaagga 241 tgaaagcaaa ggctcagcag ttgacctggg accttaacag aaatgtgacc gatatcgagt 301 gtgttaaaga tgccgactat tctatgccgg cagtgaacaa tagctattgc cagtttggag 361 caatttcctt atgtgaagtg accaactaca ccgtccgagt ggccaaccca ccattctcca 421 cgtggatcct cttccctgag aacagtggga agccttgggc aggtgcggag aatctgacct WO 00/09525 PCT/US99/17712 EPI-109 709 481 gctggattca tgacgtggat ttcttgagct gcagctgggc ggtaggcccg ggggcccccg 541 cggacgtcca gtacgacctg tacttgaacg ttgccaacag gcgtcaacag tacgagtgtc 601 ttcactacaa aacggatgct cagggaacac gtatcgggtg tcgtttcgat gacatctctc 661 gactctccag cggttctcaa agttcccaca tcctggtgcg gggcaggagc gcagccttcg 721 gtatcccctg cacagataag tttgtcgtct tttcacagat tgagatatta actccaccca 781 acatgactgc aaagtgtaat aagacacatt cctttatgca ctggaaaatg agaagtcatt 841 tcaatcgcaa atttcgctat gagcttcaga tacaaaagag aatgcagcct gtaatcacag 901 aacaggtcag agacagaacc tccttccagc tactcaatcc tggaacgtac acagtacaaa 961 taagagcccg ggaaagagtg tatgaattct tgagcgcctg gagcaccccc cagcgcttcg 1021 agtgcgacca ggaggagggc gcaaacacac gtgcctggcg gacgtcgctg ctgatcgcgc 1081 tggggacgct gctggccctg gtctgtgtct tcgtgatctg cagaaggtat ctggtgatgc 1141 agagactctt tccccgcatc cctcacatga aagaccccat cggtgacagc ttccaaaacg 1201 acaagctggt ggtctgggag gcgggcaaag ccggcctgga ggagtgtctg gtgactgaag 1261 tacaggtcgt gcagaaaact tgagactggg gttcagggct tgtgggggtc tgcctcaatc 1321 tccctggccg ggccaggcgc ctgcacagac tggctgctgg acctgcgcac gcagcccagg 1381 aatggacatt cctaacgggt ggtgggcatg ggagatgcct gtgtaatttc gtccgaagct 1441 gccaggaaga agaacagaac (2) INFORMATION FOR SEQ ID NO:2541: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 601 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2541: 1 gatcgttagc ttctcctgat aaactaattg cctcacattg tcactgcaaa tcgacaccta 61 ttaatgggtc tcacctccca actgcttccc cctctgttct tcctgctagc atgtgccggc 121 aactttgtcc acggacacaa gtgcgatatc accttacagg agatcatcaa aactttgaac 181 agcctcacag agcagaagac tctgtgcacc gagttgaccg taacagacat ctttgctgcc 241 tccaagaaca caactgagaa ggaaaccttc tgcagggctg cgactgtgct ccggcagttc 301 tacagccacc atgagaagga cactcgctgc ctgggtgcga ctgcacagca gttccacagg 361 cacaagcagc tgatccgatt cctgaaacgg ctcgacagga acctctgggg cctggcgggc 421 ttgaattcct gtcctgtgaa ggaagccaac cagagtacgt tggaaaactt cttggaaagg 481 ctaaagacga tcatgagaga gaaatattca aagtgttcga gctgaatatt ttaatttatg 541 agtttttgat agctttattt tttaagtatt tatatattta taactcatca taaaataaag 601 tatatataga atct (2) INFORMATION FOR SEQ ID NO:2542: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 9841 base- pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2542: 1 gaattcaata aaaaacaagc agggcgcgtg gtggggcact gactaggagg gctgatttgt 61 aagttggtaa gactgtagct ctttttccta attagctgag gatgtgttta ggttccattc 121 aaaaagtggg cattcctggc caggcatggt ggctcacacc tgtaatctca gagctttggg 181 agactgaggt aggaggatca cttgagccca ggaatttgag atgagcctag gcaacatagt 241 gagactctta tctctatcaa aaaataaaaa taaaaatgag ccaggcatgg tgcggtggac 301 cacgcaccta ctgctagggg ggctgaggtg ggaggatcat tgagcctggg aggttgaggc 361 tgcagtgatc cctgatcaaa cattgcattt cagcctgggt gacagagtga gaccctgtct 421 cagaaaaaaa aaaaaaaagt cattcctgaa acctcagaat agacctacct tgccaagggc 481 ttccttatgg gtaaggacct tatggacctg ctgggaccca aactaggcct cacctgatac 541 gacctgtcct tctcaaaaca ctaaacttgg gagaacattg tcccccagtg ctggggtagg 601 agagtctgcc tgttattctg cctctatgca gagaaggagc cccagatcat cttttccatg 661 acaggacagt ttccaagatg ccacctgtac ttggaagaag ccaggttaaa atacttttca 721 agtaaaactt tcttgatatt actctatctt tccccaggag gactgcatta caacaaattc 781 ggacacctgt ggcctctccc ttctatgcaa agcaaaaagc cagcagcagc cccaagctga 841 taagattaat ctaaagagca aattatggtg taatttccta tgctgaaact ttgtagttaa 901 ttttttaaaa aggtttcatt ttcctattgg tctgatttca caggaacatt ttacctgttt 961 .gtgaggcatt ttttctcctg gaagagaggt gctgattggc cccaagtgac tgacaatctg 1021 gtgtaacgaa aatttccaat gtaaactcat tttccctcgg tttcagcaat tttaaatcta 1081 tatatagaga tatctttgtc agcattgcat cgttagcttc tcctgataaa ctaattgcct 1141 cacattgtca ctgcaaatcg acacctatta atgggtctca cctcccaact gcttccccct 1201 ctgttcttcc tgctagcatg tgccggcaac tttgtccacg gacacaagtg cgatatcacc 1261 ttacaggaga tcatcaaaac tttgaacagc ctcacagagc agaaggtgag tacctatctg 1321 gcaccatctc tccagatgtt ctggtgatgc tctcagtatt tctaggcatg aaaacgttaa 1381 cagctgctag agaagttgga actggtggtt ggtggcagtc cagggcacac agcgaggctt 1441 ctccctgcca ctcttttttc tgagggtttg taggaagttt cctcagttgg agggagtgag WO 00/09525 PCT/US99/17712 EPI-109 710 1501 agctgctcat caaggactzc tctgtccggt tggaggttaa ctctgtctct tgctctctca 1561 tttctgcctg gaccaagact ctgtgcaccg agttgaccgt aacagacatc tttgctgcct 1621 ccaaggtaag aagccgtccc acggtctgtt ttagcaaatg gggagatcca tccccaaatg 1681 tctgaacaag aaacttgtct aatggaaaac gagcgggccc aaattaactc taaggtgtta 1741 gatgttttca aagaacgaga agtctgatct ttactcttaa gcatgttttg gtctttctgg 1801 tttcacttga tttagaagac atgtaataga aagcttacat gctgtagtcc tgactcagat 1861 cctggtcaaa gaaaagccct cttgggtttt acttagcttt ggcatagtgc ctggaacgta 1921 ggaggcactc aataaatgcc tgttgaatga gagaattttt ctggcccata catttctgaa 1981 aaaccaaata ctctcacaga aacagatatt gagatgacag gttgagggag ctttcatttt 2041 gtctaagaga cttcctatgg caacagaaaa ggtatcgcca gagcccctcc tcttccacag 2101 cctggccacc taacagccct ctggttccgg ggctgccgtc cagagctctc agcttgctct 2161 ggccggccga actcccctcc agctcggtct ggaaccatcc tgctgggcag cgtccagcac 2221 atccctgctt cgggctgcct gggcacctcg cctctctgcc tcctqtgctg cctcaccccc 2281 acccctctat ctgtagtggg agggagatag atttgacagc tgatagtgca ttttctctga 2341 caaacacatg actacagccg tatcaatagt tttgtgcatt tcagttcctg ttttcatgga 2401 aacacacggc tgagaatgaa agccccaaag cctcaatttc acagtggtct cctaactacc 2461 tgctttccat gcaaactagg gagatgatat ggccaggagt gaagccctgt gtgttgggca 2521 gggtcacact ccagcaccca gaccatagaa cagggcccat cctgcttcat gagggaaact 2581 gctcttcggg cctttagctg gactatctca tttcattagt tatcccggga gtccgataca 2641 ggatgagatt ctgaagggca aatacacact tttttttttt ttttgagata gggtcttgtt 2701 ctgtcaccca ggctggagtg cagtggtgcg atttcagctc atagcagcct ccacctccca 2761 ggctcaagct atcttcctac ctcagcctcc caagtagccg ggacgacagg tgtgcaccac 2821 cacgcctggc taatttttgt atttttttgt agagatggag tcttgccatt ttgcccaggc 2881 ttgtctcgaa cttctgggct caaqcaatcc gtccacctcg gcctctcaaa gtgctgggat 2941 tagccactgc acctgggcaa cagtttatgt gtgtgtgtgt gtgtgtgtgt atatatgtgt 3001 gtgtgtgtat atatatgtgt gtatgtatat atgtgtatgt atatgtgtgt gtgtgtgtgt 3061 gtgtgtgtgt gtgtataaaa tctccaagtc catccaaccg agatggctcc tactagaagc 3121 caagagtcca ccgggttgag cactgggtct ctggaggcct gtcggactgc tgagaaggct 3181 ctaacaaagc caagggaagg gccacctcac tagaagccag gcctggagga agggtgaggg 3241 ctgagggctg gaggtaagac tgcctgtggt tttagaccca ggctctgcca ctgactagct 3301 gtgtggctgg ccttcagaca tcttcacagc tctctgcacc tcagtttcca catgtgaaga 3361 tatgaaagtg attctgaagg tgattgcaag gttgattgga atccagctct tgagttagtg 3421 caaagtgtta ttgtgagatg atataaccac gattaaaagc aagaacaggt gcagagaagc 3481 gatgattcta agaaggaggg gaccgggttg gaaaggatca aaccatccag gatgccgagt 3541 ctggggcaat ccatctgggc tgtttctgga agacccccgg gtgcaggcca ggacactgct 3601 gccctcccgt ccttaactcc cctcttcact cagtcctcac tcacctccct ctcacacaca 3661 caaacatctc ctagaataat ccccactgcc tgccttcact cttacccgtc tcatttgcct 3721 cccctgaact tcatcctcct ggagttcacg atctcactct tcactctttt cttcccctcg 3781 aagattcagc actgcttact tacatgttaa gatatttcag aacagtgaaa tgttgctatt 3841 ttcaaaaacc tacaaaggtg gtatgcagag gaaaaggtac ttctttgtgt tcccaaagaa 3901 aacatctttc caaaatccag cctattgatt ttatttcttc gggggaacaa gaattttagt 3961 atctctaagt tgggtagcat tctactcttg gcagttgctg gaaagaaggc actggtctag 4021 gtcctgggct tcacaggtaa cacctgtcag ggtgtctatg aagtcaaggc tgtctgagga 4081 acagcaaagt gggaagaagc aagctggctg gctgatgaag ggtttcttgg gtggacaagt 4141 agttggagcg atttcctatt taccaaagag agctaaagtt cataattcta cagagagttc 4201 cataatgaac ctcaaatacc tctgtttttt gaaggagttt ctcatataca gcactagctg 4261 actatcctgg gcaggatggg agataatgaa tgcagtgcca atcgggctgg atttatatgg 4321 tcctagtgag gctggtcaag aaccgagtta gaactctcac agagtcactg cccacagaag 4381 aaatctccca agtggctgtt tcctgacatt cccgggaggc aggcctcctt ctgagtcact 4441 ccctaagcag ttctgaactg tgaggtcagc caggctgtcc aagtgcactc cctgagccac 4501 tggcagacac actcagcagc cagagctaga caggcaggtg gtaggagtcc agggccacgg 4561 cagggatgga gtgtcgcccc ctcgctgcga taccagagca agtaaaacgt taaggccttg 4621 cactaaagct gcccttagga tgcattcttt taaagttttt ccatttaatg cagactcttt 4681 tcaattctta ttttatcctt gtttccttta gaaagtcctt tgaaaaatat ctttagaggg 4741 ttttttccta tactatgtgg ccatatacgg gtcaaaatta agtttaattt ccaggctcca 4801 agccagcgtt tcagaaaaat ctcaccaagg tttgtggtaa aagaagcaaa gggctgactt 4861 tttggttttc ttgaatctca ctgttccctc tgcagcagca tgcatgtctg cccacctcca 4921 gacacacagg caccatctgc cgccccccat cagcccgtgt cccttccacc tcgactcgcc 4981 tacaaagccc agagaggtct gtttcttggc ccccagagcc caaagatact gacacactct 5041-tacatttcca actagaatca ggaacgagga gtgactctca gtcagttcat taagtaaatg 5101 tctttctaac cgctctgccc atgggacatc acgccccaca ggggaaaggg gaagcttctg 5161 tagcctggga ttctggtgcc tcagtctggg tctagacttt cctgaaaaaa cgttaaaata 5221 tgaactgcat tcctagaatt tagcctacat aaataagaga tgaacacaaa gatttctata 5281 gtttactcac tgccgcttat ttacagaagc aaaaatctgc cacgataggg gcctgacaaa 5341 tgacagtacc actgtgcaat gcgtttctac gcagctctca atcccatgtt ctctaatacc 5401 accgaaggct taggaaatgc ttatggtata tgtaaagagt aaagaagtta caaacagtat 5461 caacagttga cccctatttt aaaaagtatt tttgaaaagt gtgacgatat ttaccaaaat 5521 attaacgagc aatagttacc tctggctggt gggatgagtg aatgtatttt tgttgaatat WO 00/09525 PCT/US99/17712 EPI-109 711 5581 atgttacctt tatagtaaat atatgttatc ttgatcatca gaaaaaaaaa tatgtaagaa 5641 cttgaaagct gcttggacag cgctgctgat agaaacccct gagcatcttg tcactgttct 5701 tctgattcag agggtctggg tggggcaggg gtggtctgag attczazatt tctaagaagc 5761 tcccagtgat gtccatgctg ctgtccatgg accacacttt gagtatcaag ggaccagagc 5821 atgtcggggg agaggctggg gatagctttc tttatctgaa ctggataaag gaactgggct 5881 caagctaaga accctctcca ggttctgcat ctttgttctt cagtgaaaaa tgagaggaca 5941 caccaggcca ggttcagact gagacacaat ccctctcctg ggttcccaat gacttgtctc 6001 ttgtccattc ccttctctaa ggctaagggc cccccaggaa gagccargtg gccagaccct 6061 cacagttgct ggcattccaa ggagattctc actccgcatc attggtccaa aaggcccctt 6121 acagaagctc tgcccaaggc tcagatcaat ggcacctgct cccagagctc ctctgatctc 6181 ccaggacacc tttccctgat ctgtgcactt atctcttgct gcctagcaaa atgtcttagc 6241 tcctcacttg ggccatgtgc tgctctcctc tcccatgggg agagccacac ggagagtgct 6301 ggccaaagca gcagagttca ggccaaagga tgtgcactca tttattcaac aggcatgcag 6361 gatttccagg gaaagctgga ttttaaaacc tctgggaaca agagcagaac ctgactgaga 6421 gctcatgtgg gcacttttca tagcagaata gctcatgagg tatagagaca cggacgcaga 6481 acgtgggctg tagcgacaga tggtcctgca ttctagtccc cactgtgcct tttcctcatg 6541 ggatgacttt attcaggtac cctttcggca aaatcctcca agagaaagga aactgggagg 6601 ttctggggag aaggctgctg cgtttgcaat tgggagaggt tgttgacaga ggtttatgtc 6661 tgtggcaagc agccttcctt cagtggaata cttgaagaca ggtctgtagt tgagcaaact 6721 cacctccatt tgtcctcctg gaaagaagaa atcaagagga aaaatctctc tcccatcctc 6781 caaatggagc tggcacattg ctatctgtgg catttgtctt tccagaacac aactgagaag 6841 gaaaccttct gcagggctgc gactgtgctc cggcagttct acagccacca tgagaaggac 6901 actcgctgcc tgggtgcgac tgcacagcag ttccacaggc acaagcagct gatccgattc 6961 ctgaaacggc tcgacaggaa cctctggggc ctggcgggct tggtaagctg cactgtattc 7021 ctggcaagcc ggccgcgtgg ctcctggtgg acagcagcct cacttctaaa cactccttag 7081 gagctgcagc acccttggtc aacccattca ttcattcact cattcaataa gtatttgctg 7141 aagttccaca agtgctgggt gtggttctag gtgctgagga cgtgtcacta aagacagcag 7201 gccgagtccc tgttctcatg gaatgttcta atgggagagt tagaaaaaca aacatgtaaa 7261 atgatggcca gcagtgatac gtgctacaaa gaaaaacata gaaataaaga acataagagt 7321 catgggggag ggggctgact taggagctgg tgacattatc tgagcagata tttgaattga 7381 gggagcaggc cacatgacta actagggaga ccattccagg gagaaggagg aggtatgcaa 7441 aggccttagg atggaaatga actaacttcc tgtatttaaa gaccagtagg aaggccagtg 7501 tggctggatc agagtgagtg aggggtagtt tccaggacag cagatcacac aaggccttta 7561 gattccacca cgagtatgga gggaacacct gcagagcttt gggcaggaca aagactgtac 7621 aatctgattt acgtgattta aaagggtcag tctggctact gtgtggtaaa taggctgaaa 7681 gggggaaagc atagaagcaa gatggcctgt tgggaggcta ccacagtaaa ccaggctaga 7741 gatgatggtg gcgtggacag aatgaagcaa gatggcctgt tgggaggcta ccacagtaaa 7801 ccaggctaga gatgatggtg gcgtggacag aatgaagcaa gatggcctgt tgggaggcta 7861 ccacagtaaa ccaggctaga gatgatggtg gcgtggacaa atggagcagt tgaggtgaac 7921 agatttggga tatgactaaa aataaaacca gaagatttgc tgacagatcg gttgtagggg 7981 gtaagataca ggggaggaaa agatgacctc tttgttcctg cccaaacccc tctggcgatg 8041 gtcagtactg tttacagaga gatgaaagac tggcggcaag gcagggctgg aggttcagca 8101 gaagatcaag agttcaattt tgtacatcgt acatgtaagg tggctcttgg atagccaagt 8161 gaaggtgttg agaagatggt tagaaaagtc tggaacttag gggagaggtc agaacttgca 8221 atacaaaaag gagagtcctt agatagatac tgctgaaaat ctgaatgaca gaaagggaga 8281 gatcaaagga ctgagcctga gatcaacaca tggaggtcag gagaggagga tccagccaag 8341 gggcctgagg aggagtgacc agtgaggcag gagaacatgg agagtgggcg gtaccccagg 8401 aagccggtga ggacactcaa ggagggaggg ttgactgtgt caaatgtact gaaaggacag 8461 gtcaggtgag gaccaagaaa ggcccctggg tttggctgat ggaggccatg ggtgaggctg 8521 atgtaaatgg agaggcagga aggaaagccc agctggagtg ggctcaccga ggatagggtg 8581 gcgagaggag acaaagaagg aacagtgagg gcagacaact ctttgaagat gtttagctat 8641 aaggctgcag agaaactgag cccacagctg cagggtggtt atggagtgag ggaagctctt 8701 ttaaggttgg gggtataccc agcatgttaa tgcacctggg ggaatggtcc agtggagcag 8761 gaagaactga agagagcaga aagaggaaga atcattaggg ggcagaagtc cttgtagccc 8821 agagtggatg ttatctaata tcgagtggag gaattaattg gctttagagg agaacaagga 8881 catgtatccc ctctctgggc ctatcacctt gtagacaatg ggataggtca tgggatagga 8941 acttggcaca acacatgttc tctcttttaa ttctctccat tatcttatga agcaggcaag 9001 taggcaaaca attgtcccaa ctttacaaaa gaaactgaag cttttataaa ttaagtagta 9061 catcctaagc aatacaatta ataaatggta gagctgagat tcaaactgaa gcagtggcct 9121 gggggtagca tctggaatcc ttcccacctt tagggctgct gtgctgcggt gctgctgttt 9181 aatggcacag agggccagat gactgaatct ctctcagcag tccaggcagt catgcagaag 9241 gcccagtaga gcaccgggca ggtctgagcc agcatcttca agttccaccc tgtgagcaag 9301 cacttagctg tgacacactt ctcgagagac tggactcccc cccgcgcaac ccacccaaaa 9361 gcagataggt aatggtatac agtaaccatt tctagaagtg taagtagtat gcacccaaaa 9421 taggcaaaac ctgctggcct agtgatagag acaactccca gtcaggctag actggaggcc 9481 ttggttttat aagtgttcag gtgacaagtg ccacagtagg cttgatcaag tagacaggca 9541 ggcaagacaa atgcttacca atgcaagcta atgaaatgtt tcttttgcag aattcctgtc 9601 ctgtgaagga agccaaccag agtacgttgg aaaacttctt ggaaaagcta aagacgatca WO 00/09525 PCT/US99/17712 EPI-109 712 9661 tgagagagaa atattcaaag tgttcgagct gaatatttta atttatgagt ttttgatagc 9721 tttatttttt aagtatttat atatttataa ctcatcataa aataaagtat atatagaatc 9781 taacagcaat ggcatttaat gtattggcta tgtttacttg acaaatgaaa ttatggtttg 9841 caacttttag ggaaatcaat ttagtttacc aagagactat aaatgctatg gagccaaaac (2) INFORMATION FOR SEQ ID NO:2543: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 10442 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2543: 1 gatcgttagc ttctcctgat aaactaattg cctcacattg tcactgcaaa tcgacaccta 61 ttaatgggtc tcacctccca actgcttccc cctctgttct tcctgctagc atgtgccggc 121 aactttgtcc acggacacaa gtgcgatatc accttacagg agatcatcaa aactttgaac 181 agcctcacag agcagaagac tctgtgcacc gagttgaccg taacagacat ctttgctgcc 241 tccaagaaca caactgagaa ggaaaccttc tgcagggctg cgactgtgct ccggcagttc 301 tacagccacc atgagaagga cactcgctgc ctgggtgcga ctgcacagca Qttccacagg 361 cacaagcagc tgatccgatt cctgaaacgg ctcgacagga acctctgggg cctggcgggc 421 ttgaattcct gtcctgtgaa ggaagccaac cagagtacgt tggaaaactt cttggaaagg 481 ctaaagacga tcatgagaga gaaatattca aagtgttcga gctgaatatt ttaatttatg 541 agtttttgat agctttattt tttaagtatt tatatattta taactcatca taaaataaag 601 tatatataga atct 1 gaattcaata aaaaacaagc agggcgcgtg gtggggcact gactaggagg gctgatttgt 61 aagttggtaa gactgtagct ctttttccta attagctgag gatgtgttta ggttccattc 121 aaaaagtggg cattcctggc caggcatggt ggctcacacc tgtaatctca gagctttggg 181 agactgaggt aggaggatca cttgagccca ggaatttgag atgagcctag gcaacatagt 241 gagactctta tctctatcaa aaaataaaaa taaaaatgag ccaggcatgg tgcggtggac 301 cacgcaccta ctgctagggg ggctgaggtg ggaggatcat tgagcctggg aggttgaggc 361 tgcagtgatc cctgatcaaa cattgcattt cagcctgggt gacagagtga gaccctgtct 421 cagaaaaaaa aaaaaaaagt cattcctgaa acctcagaat agacctacct tgccaagggc 481 ttccttatgg gtaaggacct tatggacctg ctgggaccca aactaggcct cacctgatac 541 gacctgtcct tctcaaaaca ctaaacttgg gagaacattg tcccccagtg ctggggtagg 601 agagtctgcc tgttattctg cctctatgca gagaaggagc cccagatcat cttttccatg 661 acaggacagt ttccaagatg ccacctgtac ttggaagaag ccaggttaaa atacttttca 721 agtaaaactt tcttgatatt actctatctt tccccaggag gactgcatta caacaaattc 781 ggacacctgt ggcctctccc ttctatgcaa agcaaaaagc cagcagcagc cccaagctga 841 taagattaat ctaaagagca aattatggtg taatttccta tgctgaaact ttgtagttaa 901 ttttttaaaa aggtttcatt ttcctattgg tctgatttca caggaacatt ttacctgttt 961 gtgaggcatt ttttctcctg gaagagaggt gctgattggc cccaagtgac tgacaatctg 1021 gtgtaacgaa aatttccaat gtaaactcat tttccctcgg tttcagcaat tttaaatcta 1081 tatatagaga tatctttgtc agcattgcat cgttagcttc tcctgataaa ctaattgcct 1141 cacattgtca ctgcaaatcg acacctatta atgggtctca cctcccaact gcttccccct 1201 ctgttcttcc tgctagcatg tgccggcaac tttgtccacg gacacaagtg cgatatcacc 1261 ttacaggaga tcatcaaaac tttgaacagc ctcacagagc agaaggtgag tacctatctg 1321 gcaccatctc tccagatgtt ctggtgatgc tctcagtatt tctaggcatg aaaacgttaa 1381 cagctgctag agaagttgga actggtggtt ggtggcagtc cagggcacac agcgaggctt 1441 ctccctgcca ctcttttttc tgagggtttg taggaagttt cctcagttgg agggagtgag 1501 agctgctcat caaggacttc tctgtccggt tggaggttaa ctctgtctct tgctctctca 1561 tttctgcctg gaccaagact ctgtgcaccg agttgaccgt aacagacatc tttgctgcct 1621 ccaaggtaag aagccgtccc acggtctgtt ttagcaaatg gggagatcca tccccaaatg 1681 tctgaacaag aaacttgtct aatggaaaac gagcgggccc aaattaactc taaggtgtta 1741 gatgttttca aagaacgaga agtctgatct ttactcttaa gcatgttttg gtctttctgg 1801 tttcacttga tttagaagac atgtaataga aagcttacat gctgtagtcc tgactcagat 1861 cctggtcaaa gaaaagccct cttgggtttt acttagcttt ggcatagtgc ctggaacgta 1921 ggaggcactc aataaatgcc tgttgaatga gagaattttt ctggcccata catttctgaa 1981 aaaccaaata ctctcacaga aacagatatt gagatgacag gttgagggag ctttcatttt 2041 gtctaagaga cttcctatgg caacagaaaa ggtatcgcca gagcccctcc tcttccacag 2101 cctggccacc taacagccct ctggttccgg ggctgccgtc cagagctctc agcttgctct 2161 ggccggccga actcccctcc agctcggtct ggaaccatcc tgctgggcag cgtccagcac 2221-atccctgctt cgggctgcct gggcacctcg cctctctgcc tcctgtgctg cctcaccccc 2281 acccctctat ctgtagtggg agggagatag atttgacagc tgatagtgca ttttctctga 2341 caaacacatg actacagccg tatcaatagt tttgtgcatt tcagttcctg ttttcatgga 2401 aacacacggc tgagaatgaa agccccaaag cctcaatttc acagtggtct cctaactacc 2461 tgctttccat gcaaactagg gagatgatat ggccaggagt gaagccctgt gtgttgggca 2521 gggtcacact ccagcaccca gaccatagaa cagggcccat cctgcttcat gagggaaact 2581 gctcttcggg cctttagctg gactatctca tttcattagt tatcccggga gtccgataca 2641 ggatgagatt ctgaagggca aatacacact tttttttttt ttttgagata gggtcttgtt 2701 ctgtcaccca ggctggagtg cagtggtgcg atttcagctc atagcagcct ccacctccca WO 00/09525 PCTfUS99/17712 EPI-109 713 2761 ggctcaagct atcttcccac ctcagcctcc caagtagccg ggacgacagg tgtgcaccac 2821 cacgcctggc taattttzgt atttttttgt agagatggag tcttgccatt ttgcccaggc 2881 ttgtctcgaa cttctgggct caagcaatcc gtccacctcg gcctctcaaa gtgctgggat 2941 tagccactgc acctgggcaa cagtttatgt gtgtgtgtgt gtgtgtgtgt atatatgtgt 3001 gtgtgtgtat atatatgtgt gtatgtatat atgtgtatgt atatgtgtgt gtgtgtgtgt 3061 gtgtgtgtgt gtgtataaaa tctccaagtc catccaaccg agatggctcc tactagaagc 3121 caagagtcca ccgggttgag cactgggtct ctggaggcct gtcggactgc tgagaaggct 3181 ctaacaaagc caagggaagg gccacctcac tagaagccag gcctggagga agggtgaggg 3241 ctgagggctg gaggtaagac tgcctgtggt tttagaccca ggctctgcca ctgactagct 3301 gtgtggctgg ccttcagaca tcttcacagc tctctgcacc tcagtttcca catgtgaaga 3361 tatgaaagtg attctgaagg tgattgcaag gttgattgga atccagctct tgagttagtg 3421 caaagtgtta ttgtgagatg atataaccac gattaaaagc aagaacaggt gcagagaagc 3481 gatgattcta agaaggaggg gaccgggttg gaaaggatca aaccatccag gatgccgagt 3541 ctggggcaat ccatctgggc tgtttctgga agacccccgg gtgcaggcca ggacactgct 3601 gccctcccgt ccttaactcc cctcttcact cagtcctcac tcacctccct ctcacacaca 3661 caaacatctc ctagaataat ccccactgcc tgccttcact cttacccgtc tcatttgcct 3721 cccctgaact tcatcctcct ggagttcacg atctcactct tcactctttt cttcccctcg 3781 aagattcagc actgcttact tacatgttaa gatatttcag aacagtgaaa tgttgctatt 3841 ttcaaaaacc tacaaaggtg gtatgcagag gaaaaggtac ttctttgtgt tcccaaagaa 3901 aacatctttc caaaatccag cctattgatt ttatttcttc gggggaacaa gaattttagt 3961 atctctaagt tgggtagcat tctactcttg gcagttgctg gaaagaaggc actggtctag 4021 gtcctgggct tcacaggtaa cacctgtcag ggtgtctatg aagtcaaggc tgtctgagga 4081 acagcaaagt gggaagaagc aagctggctg gctgatgaag ggtttcttgg gtggacaagt 4141 agttggagcg atttcctatt taccaaagag agctaaagtt cataattcta cagagagttc 4201 cataatgaac ctcaaatacc tctgtttttt gaaggagttt ctcatataca gcactagctg 4261 actatcctgg gcaggatggg agataatgaa tgcagtgcca atcgggctgg atttatatgg 4321 tcctagtgag gctggtcaag aaccgagtta gaactctcac agagtcactg cccacagaag 4381 aaatctccca agtggctgtt tcctgacatt cccgggaggc aggcctcctt ctgagtcact 4441 ccctaagcag ttctgaactg tgaggtcagc caggctgtcc aagtgcactc cctgagccac 4501 tggcagacac actcagcagc cagagctaga caggcaggtg gtaggagtcc agggccacgg 4561 cagggatgga gtgtcgcccc ctcgctgcga taccagagca agtaaaacgt taaggccttg 4621 cactaaagct gcccttagga tgcattcttt taaagttttt ccatttaatg cagactcttt 4681 tcaattctta ttttatcctt gtttccttta gaaagtcctt tgaaaaatat ctttagaggg 4741 ttttttccta tactatgtgg ccatatacgg gtcaaaatta agtttaattt ccaggctcca 4801 agccagcgtt tcagaaaaat ctcaccaagg tttgtggtaa aagaagcaaa gggctgactt 4861 tttggttttc ttgaatctca ctgttccctc tgcagcagca tgcatgtctg cccacctcca 4921 gacacacagg caccatctgc cgccccccat cagcccgtgt cccttccacc tcgactcgcc 4981 tacaaagccc agagaggtct gtttcttggc ccccagagcc caaagatact gacacactct 5041 tacatttcca actagaatca ggaacgagga gtgactctca gtcagttcat taagtaaatg 5101 tctttctaac cgctctgccc atgggacatc acgccccaca ggggaaaggg gaagcttctg 5161 tagcctggga ttctggtgcc tcagtctggg tctagacttt cctgaaaaaa cgttaaaata 5221 tgaactgcat tcctagaatt tagcctacat aaataagaga tgaacacaaa gatttctata 5281 gtttactcac tgccgcttat ttacagaagc aaaaatctgc cacgataggg gcctgacaaa 5341 tgacagtacc actgtgcaat gcgtttctac gcagctctca atcccatgtt ctctaatacc 5401 accgaaggct taggaaatgc ttatggtata tgtaaagagt aaagaagtta caaacagtat 5461 caacagttga cccctatttt aaaaagtatt tttgaaaagt gtgacgatat ttaccaaaat 5521 attaacgagc aatagttacc tctggctggt gggatgagtg aatgtatttt tgttgaatat 5581 atgttacctt tatagtaaat atatgttatc ttgatcatca gaaaaaaaaa tatgtaagaa 5641 cttgaaagct gcttggacag cgctgctgat agaaacccct gagcatcttg tcactgttct 5701 tctgattcag agggtctggg tggggcaggg gtggtctgag attctgtatt tctaagaagc 5761 tcccagtgat gtccatgctg ctgtccatgg accacacttt gagtatcaag ggaccagagc 5821 atgtcggggg agaggctggg gatagctttc tttatctgaa ctggataaag gaactgggct 5881 caagctaaga accctctcca ggttctgcat ctttgttctt cagtgaaaaa tgagaggaca 5941 caccaggcca ggttcagact gagacacaat ccctctcctg ggttcccaat gacttgtctc 6001 ttgtccattc ccttctctaa ggctaagggc cccccaggaa gagccatgtg gccagaccct 6061 cacagttgct ggcattccaa ggagattctc actccgcatc attggtccaa aaggcccctt 6121 acagaagctc tgcccaaggc tcagatcaat ggcacctgct cccagagctc ctctgatctc 6181 ccaggacacc tttccctgat ctgtgcactt atctcttgct gcctggcaaa atgtcttagc 6241 tcctcacttg ggccatgtgc tgctctcctc tcccatgggg agagccacac ggagagtgct 6301 ggccaaagca gcagagttca ggccaaagga tgtgcactca tttattcaac aggcatgcag 6361 gatttccagg gaaagctgga ttttaaaacc tctgggaaca agagcagaac ctgactgaga 6421 gctcatgtgg gcacttttca tagcagaata gctcatgagg tatagagaca cggacgcaga 6481 acgtgggctg tagcgacaga tggtcctgca ttctagtccc cactgtgcct tttcctcatg 6541 ggatgacttt attcaggtac cctttcggca aaatcctcca agagaaagga aactgggagg 6601 ttctggggag aaggctgctg cgtttgcaat tgggagaggt tgttgacaga ggtttatgtc 6661 tgtggcaagc agccttcctt cagtggaata cttgaagaca ggtctgtagt tgagcaaact 6721 cacctccatt tgtcctcctg gaaagaagaa atcaagagga aaaatctctc tcccatcctc 6781 caaatggagc tggcacatg ctatctgtgg catttgtctt tccagaacac aactgagaag WO 00/09525 PCT/US99/17712 EPI-109 714 6841 gaaaccttct gcagggctgc gactgtgctc cggcagttct acagccacca tgagaaggac 6901 actcgctgcc tgggtgcgac tgcacagcag ttccacaggc acaagcagct gatccgattc 6961 ctgaaacggc tcgacaggaa cctctggggc ctggcgggct tggtaagctg cactgtattc 7021 ctggcaagcc ggccgcgtgg ctcctggtgg acagcagcct cacttctaaa cactccttag 7081 gagctgcagc acccttggtc aacccattca ttcattcact cattcaataa gtatttgctg 7141 aagttccaca agtgctgggt gtggttctag gtgctgagga cgtgtcacta aagacagcag 7201 gccgagtccc tgttctcata gaatgttcta atgggagagt tagaaaaaca aacatgtaaa 7261 atgatggcca gcagtgatac gtgctacaaa gaaaaacata gaaataaaga acataagagt 7321 catgggggag ggggctgact caggagctgg tgacattatc tgagcagata tttgaattga 7381 gggagcaggc cacatgacta actagggaga ccattccagg qagaaggagg aggtatgcaa 7441 aggccttagg atggaaataa actaacttcc tgtatttaaa gaccagtagg aaggccagtg 7501 tggctggatc agagtgagtg aggggtagtt tccaggacag cagatcacac aaggccttta 7561 gattccacca cgagtatgga gggaacacct gcagagcttt gggcaggaca aagactgtac 7621 aatctgattt acgtgattta aaagggtcag tctggctact gtgtggtaaa taggctgaaa 7681 gggggaaagc atagaagcaa gatggcctgt tgggaggcta ccacagtaaa ccaggctaga 7741 gatgatggtg gcgtggacag aatgaagcaa gatggcctgt tgggaggcta ccacagtaaa 7801 ccaggctaga gatgatggtg gcgtggacag aatgaagcaa gatggcctgt tgggaggcta 7861 ccacagtaaa ccaggctaga gatgatggtg gcgtggacaa atggagcagt tgaggtgaac 7921 agatttggga tatgactaaa aataaaacca gaagatttgc tgacagatcg gttgtagggg 7981 gtaagataca ggggaggaaa agatgacctc tttgttcctg cccaaacccc tctggcgatg 8041 gtcagtactg tttacagaga gatgaaagac tggcggcaag gcagggctgg aggttcagca 8101 gaagatcaag agttcaattt tgtacatcgt acatgtaagg tggctcttgg atagccaagt 8161 gaaggtgttg agaagatggt tagaaaagtc tggaacttag gggagaggtc agaacttgca 8221 atacaaaaag gagagtcctt agatagatac tgctgaaaat ctgaatgaca gaaagggaga 8281 gatcaaagga ctgagcctga gatcaacaca tggaggtcag gagaggagga tccagccaag 8341 gggcctgagg aggagtgacc agtgaggcag gagaacatgg agagtgggcg gtaccccagg 8401 aagccggtga ggacactcaa ggagggaggg ttgactgtgt caaatgtact gaaaggacag 8461 gtcaggtgag gaccaagaaa ggcccctggg tttggctgat ggaggccatg ggtgaggctg 8521 atgtaaatgg agaggcagga aggaaagccc agctggagtg ggctcaccga ggatagggtg 8581 gcgagaggag acaaagaagg aacagtgagg gcagacaact ctttgaagat gtttagctat 8641 aaggctgcag agaaactgag cccacagctg cagggtggtt atggagtgag ggaagctctt 8701 ttaaggttgg gggtataccc agcatgttaa tgcacctggg ggaatggtcc agtggagcag 8761 gaagaactga agagagcaga aagaggaaga atcattaggg ggcagaagtc cttgtagccc 8821 agagtggatg ttatctaata tcgagtggag gaattaattg gctttagagg agaacaagga 8881 catgtatccc ctctctgggc ctatcacctt gtagacaatg ggataggtca tgggatagga 8941 acttggcaca acacatgttc tctcttttaa ttctctccat tatcttatga agcaggcaag 9001 taggcaaaca attgtcccaa ctttacaaaa gaaactgaag cttttataaa ttaagtagta 9061 catcctaagc aatacaatta ataaatggta gagctgagat tcaaactgaa gcagtggcct 9121 gggggtagca tctggaatcc ttcccacctt tagggctgct gtgctgcggt gctgctgttt 9181 aatggcacag agggccagat gactgaatct ctctcagcag tccaggcagt catgcagaag 9241 gcccagtaga gcaccgggca ggtctgagcc agcatcttca agttccaccc tgtgagcaag 9301 cacttagctg tgacacactt ctcgagagac tggactcccc cccgcgcaac ccacccaaaa 9361 gcagataggt aatggtatac agtaaccatt tctagaagtg taagtagtat gcacccaaaa 9421 taggcaaaac ctgctggcct agtgatagag acaactccca gtcaggctag actggaggcc 9481 ttggttttat aagtgttcag gtgacaagtg ccacagtagg cttgatcaag tagacaggca 9541 ggcaagacaa atgcttacca atgcaagcta atgaaatgtt tcttttgcag aattcctgtc 9601 ctgtgaagga agccaaccag agtacgttgg aaaacttctt ggaaaggcta aagacgatca 9661 tgagagagaa atattcaaag tgttcgagct gaatatttta atttatgagt ttttgatagc 9721 tttatttttt aagtatttat atatttataa ctcatcataa aataaagtat atatagaatc 9781 taacagcaat ggcatttaat gtattggcta tgtttacttg acaaatgaaa ttatggtttg 9841 caacttttag ggaaatcaa ttagtttacc aagagactat aaatgctatg gagccaaaac (2) INFORMATION FOR SEQ ID NO:2544: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 3541 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2544: 1 ggcgaatgga gcaggggcgc gcagataatt aaagatttac acacagctgg aagaaatcat 61 agagaagccg ggcgtggtgg ctcatgccta taatcccagc acttttggag gctgaggcgg 121 gcagatcact tgagatcagg agttcgagac cagcctggtg ccttggcatc tcccaatggg 181 gtggctttgc tctgggctcc tgttccctgt gagctgcctg gtcctgctgc aggtggcaag 241 ctctgggaac atgaaggtct gcaggagcc cacctgcgtc tccgactaca tgagcatctc 301 tacttgcgag tggaagatga atggtcccac caattgcagc accgagctcc gcctgttgta 361 ccagctggtt tttctgctct ccgaagccca cacgtgtatc ccgagaaca acggaggcgc 421 ggggtgcgtg tgccacccgc acatggatga cgtggtcagt gcggataact atacactgga 481 cctgtgggct gggcagcagc tgctgtggaa gggctccttc aagcccagcg agcatgtgaa 541 acccagggcc ccaggaaacc zgacagttca caccaatgtc tccgacactc tgctgctgac WO 00/09525 PCT/US99/17712 EPI-109 715 601 ctggagcaac ccgtatcccc ctgacaatta cctgtataat catctcacct atgcagtcaa 661 catttggagt gaaaacgacc cggcagattt cagaatctat aacgtgacct acctagaacc 721 ctccctccgc atcgcagcca gcaccctgaa gtctgggatt tcctacaggg cacgggtgag 781 ggcctgggct cagtgctata acaccacctg gagtgagtgg agccccagca ccaagtggca 841 caactcctac agggagccct tcgagcagca cctcctgctg ggcgtcagcg tttcctgcat 901 tgtcatcctg gccgtctgcc tgttgtgcta tgtcagcatc accaagat-ta agaaagaatg 961 gtgggatcag attcccaacc cagcccgcag ccgcctcgtg gctataataa tccaggatgc 1021 tcaggggtca cagtgggaga agcggtcccg aggccaggaa ccagccaagt gcccacactg 1081 gaagaattgt cttaccaagc tcttgccctg ttttctggag cacaacatga aaagggatga 1141 agatcctcac aaggctgcca aagagatgcc tttccagggc tctggaaaat cagcatggtg 1201 cccagtggag atcagcaaga cagtcctctg gccagagagc atcagcgtgg tgcgatgtgt 1261 ggagttgttt gaggccccgg tggagtgtga ggaggaggag gaggtagagg aagaaaaagg 1321 gagcttctgt gcatcgcctg agagcagcag ggatgacttc caggagggaa gggagggcat 1381 tgtggcccgg ctaacagaga gcctgttcct ggacctgctc ggagaggaga atgggggctt 1441 ttgccagcag gacatggggg agtcatgcct tcttccacct tcgggaagta cgagtgctca 1501 catgccctgg gatgagttcc caagtgcagg gcccaaggag gcacctccct ggggcaagga 1561 gcagcctctc cacctggagc caagtcctcc tgccagcccg acccagagtc cagacaacct 1621 gacttgcaca gagacgcccc tcgtcatcgc aggcaaccct gcttaccgca gcttcagcaa 1681 ctccctgagc cagtcaccgt gtcccagaga gctgggtcca gacccactgc tggccagaca 1741 cctggaggaa gtagaacccg agatgccctg tgtcccccag ctctctgagc caaccactgt 1801 gccccaacct gagccagaaa cctgggagca gatcctccgc cgaaatgtcc tccagcatgg 1861 ggcagctgca gcccccgtct cggcccccac cagtggctat caggagtttg tacatgcggt 1921 ggagcagggt ggcacccagg ccagtgcggt ggtgggcttg ggtcccccag gagaggctgg 1981 ttacaaggcc ttctcaagcc tgcttgccag cagtgctgtg tccccagaga aatgtgggtt 2041 tggggctagc agtggggaag aggggtataa gcctttccaa gacctcattc ctggctgccc 2101 tggggaccct gccccagtcc ctgtcccctt gttcaccttt ggactggaca gggagccacc 2161 tcgcagtccg cagagctcac atctcccaag cagctcccca gagcacctgg gtctggagcc 2221 gggggaaaag gtagaggaca tgccaaagcc cccacttccc caggagcagg ocacagaccc 2281 ccttgtggac agcctgggca gtggcattgt ctactcagcc cttacctgcc acctgtgcgg 2341 ccacctgaaa cagtgtcatg gccaggagga tggtggccag acccctgtca tggccagtcc 2401 ttgctgtggc tgctgctgtg gagacaggtc ctcgccccct acaacccccc tgagggcccc 2461 agacccctct ccaggtgggg ttccactgga ggccagtctg tgtccggcct ccctggcacc 2521 ctcgggcatc tcagagaaga gtaaatcctc atcatccttc catcctgccc ctggcaatgc 2581 tcagagctca agccagaccc ccaaaatcgt gaactttgtc tccgtgggac ccacatacat 2641 gagggtctct taggtgcatg tcctcttgtt gctgagtctg cagatgagga ctagggctta 2701 tccatgcctg ggaaatgcca cctcctggaa ggcagccagg ctggcagatt tccaaaagac 2761 ttgaagaacc atggtatgaa ggtgattggc cccactgacg ttggcctaac actgggctgc 2821 agagactgga ccccgcccag cattgggctg ggctcgccac atcccatgag agtagagggc 2881 actgggtcgc cgtgccccac ggcaggcccc tgcaggaaaa ctgaggccct tgggcacctc 2941 gacttgtgaa cgagttgttg gctgctccct ccacagcttc tgcagcagac tgtccctgtt 3001 gtaactgccc aaggcatgtt ttgcccacca gatcatggcc cacgtggagg cccacctgcc 3061 tctgtctcac tgaactagaa gccgagccta gaaactaaca cagccatcaa gggaatgact 3121 tgggcggcct tgggaaatcg atgagaaatt gaacttcagg gagggtggtc attgcctaga 3181 ggtgctcatt catttaacag agcttcctta ggttgatgct ggaggcagaa tcccggctgt 3241 caaggggtgt tcagttaagg ggagcaacag aggacatgaa aaattgctat gactaaagca 3301 gggacaattt gctgccaaac acccatgccc agctgtatgg ctgggggctc ctcgtatgca 3361 tggaaccccc agaataaata tgctcagcca ccctgtgggc cgggcaatcc agacagcagg 3421 cataaggcac cagttaccct gcatgttggc ccagacctca ggtgctaggg aaggcgggaa 3481 ccttgggttg agtaatgctc gtctgtgtgt tttagtttca tcacctgtta tctgtgtttg 3541 ctgaggagag tggaacagaa ggggtggagt tttgtataaa taaagtttct ttgtctc (2) INFORMATION FOR SEQ ID NO:2545: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 3241 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear. (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2545: 1 ggatcctaat caagacccca gtgaacagaa ctcgaccctg ccaaggcttg gcagtttcca 61 tttcaatcac tgtcttccca ccagtatttt caatttcttt taagacagat taatctagcc 121 acagtcatag tagaacatag ccgatctgaa aaaaacattc ccaatattta tgtattttag 181 cataaaattc tgtttagtgg tctaccttat actttgtttt gcacacatct tttaagagga 241 agttaatttt ctgattttaa gaaatgcaaa tgtggggcaa tgatgtatta acccaaagat 301 tcttcgtaat aaaaaatgtt tttaaagggg ggaaacaggg atttttatta ttaaaagata 361 aaagtaaatt tattttttaa gatataaggc attggaaaca tttagtttca cgatatgcca 421 ttattaggca ttctctatct gattgttaga aattattcat ttcctcaaag acagacaata 481 aattgactgg ggacgcagtc ttgtactatg cactttcttt gccaaaggca aacgcagaac 541 gtttcagagc catgaggatg cttctgcatt tgagtttgct agctcttgga gctgcctacg 601 tgtatgccat ccccacagaa attcccacaa gtgcattggt gaaagagacc ttggcactgc WO 00/09525 PCT/US99/17712 EPI-109 716 661 tttctactca ccgaactctg ctgatagcca atgaggtaat tttctttatg attcctacag 721 tctgtaaagt gcataggtaa tcatttgtga tggttccttt actatatata gagatctgtt 781 ataaataata agattctgag cacattagta catgggtgat aactacatca ccagcaaaca 841 ttctgttaaa agttatgaat gctggtgtgc tgtaaaaatg attgtatttc ctttcctctc 901 cagactctga ggattcctgt tcctgtacat aaaaatgtaa gttaaattat gattcagtaa 961 aatgatggca tgaataagta aatttcctgt tttaagctgt aaatcattag ttatcattgg 1021 aactatttaa ttttctatat tttgttttca tatgggtggc tgtgaatgtc tgtacttata 1081 aatatgagga atgacttttt atcaagtaga atcctttaaa caagtggatt aggctctttg 1141 gtgatgttgt tagtttgcct cccaaagagc atcgtgtcag ggattctttc cagaaggatt 1201 ccacactgag tgagaggtgc gtgctagtct ccgtgcagtt ctgactcttt ctcactctaa 1261 cgtgtttctg aaagtattag caactcagaa ttatattttt agaaccatga tcagtagaca 1321 ttaaaatata taacaaatgc cctatattaa taatttctgc atacttaaat aattatgact 1381 atatgatggt gttgtatgca tttgaatatg tcctggtcat attaaaatgt aaaatatata 1441 gttttattag tctaaataga ataaaactac cagctagaac tgtagaaaca cattgatatg 1501 agtttaatgt ataatgcatt acacttccaa aacatttttt tccagttaca taattaagtt 1561 atatccttta taaaactcct cagtaatcat ataagcttca tctacttttt gaaaatttta 1621 tcttaatatg tggtggtttg ttgcctagaa aacaaacaaa aaactctttg gagaagggaa 1681 ctcatgtaaa taccacaaaa caaagcctaa ctttgtggac caaaattgtt ttaataatta 1741 ttttttaatt gatgaattaa aaagtatata tatttattgt gtacaatatg atgttttgaa 1801 gtatgtatac attgcagaat ggacaatgga ccaaattttt ataccttgtc ttgattattt 1861 gcattttaaa aattttcctc atttagcacc aactgtgcac tgaagaaatc tttcagggaa 1921 taggcacact ggagagtcaa actgtgcaag ggggtactgt ggaaagacta ttcaaaaact 1981 tgtccttaat aaagaaatac attgacggcc aaaaagtaag ttacacacat tcaatggaag 2041 ctatatttgt ctggctgtgc ctatttctat ggaattgaca gtttcctgta atacctattg 2101 tcatttttct tttttcacag aaaaagtgtg gagaagaaag acggagagta aaccaattcc 2161 tagactacct gcaagagttt cttggtgtaa tgaacaccga gtggataata gaaagttgag 2221 actaaactgg tttgttgcag ccaaagattt tggaggagaa ggacatttta ctgcagtgag 2281 aatgagggcc aagaaagagt caggccttaa ttttcagtat aatttaactt cagagggaaa 2341 gtaaatattt caggcatact gacactttgc cagaaagcat aaaattctta aaatatattt 2401 cagatatcag aatcattgaa gtattttcct ccaggcaaaa ttgatatact tttttcttat 2461 ttaacttaac attctgtaaa atgtctgtta acttaatagt atttatgaaa tggttaagaa 2521 tttggtaaat tagtatttat ttaatgttat gttgtgttct aataaaacaa aaatagacaa 2581 ctgttcaatt tgctgctggc ctctgtctta gcaattgaag ttagcacagt ccattgagta 2641 catgcccagt ttggaggaag ggtctgagca catgtggctg agcatcccca tttctctgga 2701 gaagtctcaa ggttgcaagg cacaccagag gtggaagtga tctagcagga cttagtgggg 2761 atgtggggag cagggacaca ggcaggaggt gaacctggtt ttctctctac agtatatcca 2821 gaacctggga tggtgcaggg taaatggtag ggaataaatg aatgaatgtg ctttccaaga 2881 ctgattgtag aactaaaatg agttgtaagg cgtcccctgg aagaagggca gtgtgggaac 2941 ctgtaactag gttcctgccc agcctgtgag aagaatttgg cagatcaatc tcattgccag 3001 tatagagagg aagccagaaa ccctctctgc caaggcctgc aggggttctt accccacctg 3061 accctgcacc ataacaaaag gaacagagag acactggtag ggcagtccca ttagaaagac 3121 tgagttccgt attcccgggg gcagggcagc accaggccgc acaacactcc attctgcctg 3181 cttatggcta tcagtagcat cactagagat tcttctgttt gagaaaactt ctcaaggatc 3241 c (2) INFORMATION FOR SEQ ID NO:2546: (1) SEQUENCE CHARACTERISTICS: (A) LENGTH: 781 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2546: 1 atgcactttc tttgccaaag gcaaacgcag aacgtttcag agccatgagg atgcttctgc 61 atttgagttt gctagctctt ggagctgcct acgtgtatgc catccccaca gaaattccca 121 caagtgcatt ggtgaaagag accttggcac tgctttctac tcatcgaact ctgctgatag 181 ccaatgagac tctgaggatt cctgttcctg tacataaaaa tcaccaactg tgcactgaag 241 aaatctttca gggaataggc acactggaga gtcaaactgt gcaagggggt actgtggaaa 301 gactattcaa aaacttgtcc ttaataaaga aatacattga cggccaaaaa aaaaagtgtg 361 gagaagaaag acggagagta aaccaattcc tagactacct gcaagagttt cttggtgtaa 421 tgaacaccga gtggataata gaaagttgag actaaactgg tttgttgcag ccaaagattt 481 tggaggagaa ggacatttta ctgcagtgag aatgagggcc aagaaagagt caggccttaa 541 ttttcaatat aatttaactt cagagggaaa gtaaatattt caggcatact gacactttgc 601 cagaaagcat aaaattctta aaatatattt cagatatcag aatcattgaa gtattttcct 661 ccaggcaaaa ttgatatact tttttcttat ttaacttaac attctgtaaa atgtctgtta 721 acttaatagt atttatgaaa tggttaagaa tttggtaaat tagtatttat ttaatgttat 781 gttgtgttct aataaaacaa aaatagacaa ctgttc (2) INFORMATION FOR SEQ ID NO:2547: (i) SEQUENCE CHARACTERISTICS: WO 00/09525 PCTIUS99/17712 EPI-109 717 (A) LENGTH: 4022 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2547: 1 ggatcctaat caagacccca gtgaacagaa ctcgaccctg ccaaggcttg gcagtttcca 61 tttcaatcac tgtcttccca ccagtatttt caatttcttt taagacagat taatctagcc 121 acagtcatag tagaacatag ccgatctgaa aaaaacattc ccaatattta tgtattttag 181 cataaaattc tgtttagtgg tctaccttat actttgtttt gcacacatct tttaagagga 241 agttaatttt ctgattttaa gaaatgcaaa tgtggggcaa tgatgtatta acccaaagat 301 tcttcgtaat agaaaatgtt tttaaagggg ggaaacaggg atttttatta ttaaaagata 361 aaagtaaatt tattttttaa gatataaggc attggaaaca tttagtttca cgatatgcca 421 ttattaggca ttctctatct gattgttaga aattattcat ttcctcaaag acagacaata 481 aattgactgg ggacgcagtc ttgtactatg cactttcttt gccaaaggca aacgcagaac 541 gtttcagagc catgaggatg cttctgcatt tgagtttgct agctcttgga gctgcctacg 601 tgtatgccat ccccacagaa attcccacaa gtgcattggt gaaagagacc ttggcactgc 661 tttctactca tcgaactctg ctgatagcca atgaggtaat tttctttatg attcctacag 721 tctgtaaagt gcataggtaa tcatttgtga tggttccttt actatatata gagatctgtt 781 ataaataata agattctgag cacattagta catgggtgat aactacatca ccagcaaaca 841 ttctgttaaa agttatgaat gctggtgtgc tgtaaaaatg attgtatttc ctttcctctc 901 cagactctga ggattcctgt tcctgtacat aaaaatgtaa gttaaattat gattcagtaa 961 aatgatggca tgaataagta aatttcctgt tttaagctgt aaatcattag ttatcattgg 1021 aactatttaa ttttctatat tttgttttca tatgggtggc tgtgaatgtc tgtacttata 1081 aatatgagga atgacttttt atcaagtaga atcctttaaa caagtggatt aggctctttg 1141 gtgatgttgt tagtttgcct cccaaagagc atcgtgtcag ggattctttc cagaaggatt 1201 ccacactgag tgagaggtgc gtgctagtct ccgtgcagtt ctgactcttt ctcactctaa 1261 cgtgtttctg aaagtattag caactcagaa ttatattttt agaaccatga tcagtagaca 1321 ttaaaatata taacaaatgc cctatattaa taatttctgc atacttaaat aattatgact 1381 atatgatggt gttgtatgca tttgaatatg tcctggtcat attaaaatgt aaaatatata 1441 gttttattag tctaaataga ataaaactac cagctagaac tgtagaaaca cattgatatg 1501 agtttaatgt ataatgcatt acacttccaa aacatttttt tccagttaca taattaagtt 1561 atatccttta taaaactcct cagtaatcat ataagcttca tctacttttt gaaaatttta 1621 tcttaatatg tggtggtttg ttgcctagaa aacaaacaaa aaactctttg gagaagggaa 1681 ctcatgtaaa taccacaaaa caaagcctaa ctttgtggac caaaattgtt ttaataatta 1741 ttttttaatt gatgaattaa aaagtatata tatttattgt gtacaatatg atgttttgaa 1801 gtatgtatac attgcagaat ggacaatgga ccaaattttt ataccttgtc ttgattattt 1861 gcattttaaa aattttcctc atttagcacc aactgtgcac tgaagaaatc tttcagggaa 1921 taggcacact ggagagtcaa actgtgcaag ggggtactgt ggaaagacta ttcaaaaact 1981 tgtccttaat aaagaaatac attgacggcc aaaaagtaag ttacacacat tcaatggaag 2041 ctatatttgt ctggctgtgc ctatttctat ggaattgaca gtttcctgta atacctattg 2101 tcatttttct tttttcacag aaaaagtgtg gagaagaaag acggagagta aaccaattcc 2161 tagactacct gcaagagttt cttggtgtaa tgaacaccga gtggataata gaaagttgag 2221 actaaactgg tttgttgcag ccaaagattt tggaggagaa ggacatttta ctgcagtgag 2281 aatgagggcc aagaaagagt caggccttaa ttttcagtat aatttaactt cagagggaaa 2341 gtaaatattt caggcatact gacactttgc cagaaagcat aaaattctta aaatatattt 2401 cagatatcag aatcattgaa gtattttcct ccaggcaaaa ttgatatact tttttcttat 2461 ttaacttaac attctgtaaa atgtctgtta acttaatagt atttatgaaa tggttaagaa 2521 tttggtaaat tagtatttat ttaatgttat gttgtgttct aataaaacaa aaatagacaa 2581 ctgttcaatt tgctgctggc ctctgtctta gcaattgaag ttagcacagt ccattgagta 2641 catgcccagt ttggaggaag ggtctgagca catgtggctg agcatcccca tttctctgga 2701 gaagtctcaa ggttgcaagg cacaccagag gtggaagtga tctagcagga cttagtgggg 2761 atgtggggag cagggacaca ggcaggaggt gaacctggtt ttctctctac agtatatcca 2821 gaacctggga tggtgcaggg taaatggtag ggaataaatg aatgaatgtg ctttccaaga 2881 ctgattgtag aactaaaatg agttgtaagg cgtcccctgg aagaagggca gtgtgggaac 2941 ctgtaactag gttcctgccc agcctgtgag aagaatttgg cagatcaatc tcattgccag 3001 tatagagagg aagccagaaa ccctctctgc caaggcctgc aggggttctt accccacctg 3061 accctgcacc ataacaaaag geacagagag acactggtag ggcagtccca ttagaaagac 3121 tgagttccgt attcccgggg gcagggcagc accaggccgc acaacactcc attctgcctg 3181 cttatggcta tcagtagcat cactagagat tcttctgttt gagaaaactt ctcaaggatc 3241 c 1 atgcactttc tttgccaaag gcaaacgcag aacgtttcag agccatgagg atgcttctgc 61 atttgagttt gctagctctt ggagctgcct acgtgtatgc catccccaca gaaattccca 121 caagtgcatt ggtgaaagag accttggcac tgctttctac tcatcgaact ctgctgatag 181 ccaatgagac tctgaggatt cctgttcctg tacataaaaa tcaccaactg tgcactgaag 241 aaatctttca gggaataggc acactggaga gtcaaactgt gcaagggggt actgtggaaa 301 gactattcaa aaacttgtcc ttaataaaga aatacattga cggccaaaaa aaaaagtgtg 361 gagaagaaag acggagagta aaccaattcc tagactacct gcaagagttt cttggtgtaa 421 tgaacaccga gtggataata gaaagttgag actaaactgg tttgttgcag ccaaagattt 481 tggaggagaa ggacatttta ctgcagtgag aatgagggcc aagaaagagt caggccttaa WO 00/09525 PCT/US99/17712 EPI-109 718 541 ttttcaatat aatttaactt cagagggaaa gtaaatattt caggcatact gacactttgc 601 cagaaagcat aaaattctra aaatatattt cagatatcag aatcattgaa gtattttcct 661 ccaggcaaaa ttgatatact tttttcttat ttaacttaac attctgtaaa atgtctgtta 721 acttaatagt atttatgaaa tggttaagaa tttggtaaat tagtatttat ttaatgttat 781 gttgtgttct aataaaacaa aaatagacaa ctgttc (2) INFORMATION FOR SEQ ID NO:2548: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1981 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2548: 1 tagatgctgg ggttgcagcc acgagcatag acacgacaga cacggtcctc gccatcttct 61 gttgagtact ggtcggaaca agaggatcgt ctgtagacag gatatgatca tcgtggcgca 121 tgtattactc atccttttgg gggccactga gatactgcaa gctgacttac ttcctgatga 181 aaagatttca cttctcccac ctgtcaattt caccattaaa gttactggtt tggctcaagt 241 tcttttacaa tggaaaccaa atcctgatca agagcaaagg aatgttaatc tagaatatca 301 agtgaaaata aacgctccaa aagaagatga ctatgaaacc agaatcactg aaagcaaatg 361 tgtaaccatc ctccacaaag gcttttcagc aagtgtgcgg accatcctgc agaacgacca 421 ctcactactg gccagcagct gggcttctgc tgaacttcat gccccaccag ggtctcctgg 481 aacctcaatt gtgaatttaa cttgcaccac aaacactaca gaagacaatt attcacgttt 541 aaggtcatac caagtttccc ttcactgcac ctggcttgtt ggcacagatg cccctgagga 601 cacgcagtat tttctctact ataggtatgg ctcttggact gaagaatgcc aagaatacag 661 caaagacaca ctggggagaa atatcgcatg ctggtttccc aggactttta tcctcagcaa 721 agggcgtgac tggcttgcgg tgcttgttaa cggctccagc aagcactctg ctatcaggcc 781 ctttgatcag ctgtttgccc ttcacgccat tgatcaaata aatcctccac tgaatgtcac 841 agcagagatt gaaggaactc gtctctctat ccaatgggag aaaccagtgt ctgcttttcc 901 aatccattgc tttgattatg aagtaaaaat acacaataca aggaatggat atttgcagat 961 agaaaaattg atgaccaatg cattcatctc aataattgat gatctttcta agtacgatgt 1021 tcaagtgaga gcagcagtga gctccatgtg cagagaggca gggctctgga gtgagtggag 1081 ccaacctatt tatgtgggaa atgatgaaca caagcccttg agagagtggt ttgtcattgt 1141 gattatggca accatctgct tcatcttgtt aattctctcg cttatctgta aaatatgtca 1201 tttatggatc aagttgtttc caccaattcc agcaccaaaa agtaatatca aagatctctt 1261 tgtaaccact aactatgaga aagctggaat ttaaattcaa gcatgtttta acttttggtt 1321 taaggtactt gggtgtacct ggcagtgttg taagctcttt acattaatta attaactctc 1381 taggtactgt tatcttcatt ttataaacaa ggcagctgaa gttgagagaa ataagtaacc 1441 tgtcctaggt cacacaatta ggaaatgaca gatctggcag tctatttcca ggcagtctat 1501 ttccacgagg tcatgagtgc gaaagaggga ctaggggaag aatgattaac tccagggagc 1561 tgacttttct agtgtgctta cctgttttgc atctctcaag gatgtgccat gaagctgtag 1621 ccaggtggaa ttgtaccaca gccctgacat gaacacctga tggcagctgc tgggttggag 1681 cctagacaaa aacatgaaga accatggctg ctgcctgagc ccatcgtgct gtaattatag 1741 aaaaccttct aagggaagaa tatgctgata tttttcagat aagtacccct tttataaaaa 1801 tcctccaagt tagccctcga ttttccatgt aaggaaacag aggctttgag ataatgtctg 1861 tctcctaagg gacaaagcca ggacttgatc ctgtcttaaa aatgcaaaat gtagtacttc 1921 ttccatcaaa ggtagacatg cactaaggga caggttttgg cttggtatca gaatacattt 1981 ttaaaagctg tgtaagaatt gaacgggctg tactaggggg tata (2) INFORMATION FOR SEQ ID NO:2549: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 901 base Pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2549: 1 gatctttcta agtacgatgt tcaagtgaga gcagcagtga gctccatgtg cagagaggca 61 gggctctgga gtgagtggag ccaacctatt tatgtgggaa atgatgaaca caagcccttg 121 agagagtggt ttgtcattgt gattatggca accatctgct tcatcttgtt aattctctcg 181 cttatctgta aaatatgtca tttatggatc aagttgtttc caccaattcc agcaccaaaa 241. agtaatatca aagatctctt tgtaaccact aactatgagg tcctctgcat tttcatatac 301 atcttagatt cggctgacaa ttttctacaa aaaaagaaag ctgggtccag tgagacggaa 361 attgaagtca tctgttatat agagaagcct ggagttgaga cccggagga ttctgtgttt 421 tgactgtcac tttggcatcc tctgatgaac tcacacatgc ctcagtgcct cagtgaaaag 481 aacagggatg ctggctcttg gctaagaggt gttcagaatt taggcaacac tcaatttacc 541 tgcgaagcaa tacacccaga cacaccagtc ttgtatctct taaaagtatg gatgcttcat 601 ccaaatcgcc tcacctacag cagggaagtt gactcatcca agcattttgc catgtttttt 661 ctccccatgc cgtacagggt agcacctcct cacctgccaa tctttgcaat ttgcttgact 721 cacctcagac ttttcattca caacagacag cttttaaggc taacgtccag ctgtatttac WO 00/09525 PCTIUS99/17712 EPI-109 719 781 ttctggctgt gcccgtttgg ctgtttaagc tgccaattgt agcactcagc taccatctga 841 ggaagaaagc attttgcatc agcctggagt gaaccatgaa cttggattca agactgtctt 901 ttctatagca agtgagagcc acaaattcct c (2) INFORMATION FOR SEQ ID NO:2550: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1321 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2550: 1 ccgctgcttc tcatcgcatg gccaccgcat ttctcaggcc aggcacattg agcattggtc 61 ctgtgcctga cgctatgcta gatgctgggg ttgcagccac gagcatagac acgacagaca 121 cggtcctcgc catcttctgt tgagtactgg tcggaacaag aggatcgtct gtagacaggc 181 tacagattgt tttagattga agtttcctgt catgttcact catctttaaa tcctcatagt 241 aaaaaggata tgatcatcgt ggcgcatgta ttactcatcc ttttgggggc cactgagata 301 ctgcaagctg acttacttcc tgatgaaaag atttcacttc tcccacctgt caatttcacc 361 attaaagtta ctggtttggc tcaagttctt ttacaatgga aaccaaatcc tgatcaagag 421 caaaggaatg ttaatctaga atatcaagtg aaaataaacg ctccaaaaga agatgactat 481 gaaaccagaa tcactgaaag caaatgtgta accatcctcc acaaaggctt ttcagcaagt 541 gtgcggacca tcctgcagaa cgaccactca ctactggcca gcagctgggc ttctgctgaa 601 cttcatgccc caccagggtc tcctggaacc tcaattgtga atttaacttg caccacaaac 661 actacagaag acaattattc acgtttaagg tcataccaag tttcccttca ctgcacctgg 721 cttgttggca cagatgcccc tgaggacacg cagtattttc tctactatag gtatggctct 781 tggactgaag aatgccaaga atacagcaaa gacacactgg ggagaaatat cgcatgctgg 841 tttcccagga cttttatcct cagcaaaggg cgtgactggc tttcggtgct tgttaacggc 901 tccagcaagc actctgctat caggcccttt gatcagctgt ttgcccttca cgccattgat 961 caaataaatc ctccactgaa tgtcacagca gagattgaag gaactcgtct ctctatccaa 1021 tgggagaaac cagtgtctgc ttttccaatc cattgctttg attatgaagt aaaaatacac 1081 aatacaagga atggatattt gcagatagaa aaattgatga ccaatgcatt catctcaata 1141 attgatgatc tttctaagta cgatgttcaa gtgagagcag cagtgagctc catgtgcaga 1201 gaggcagggc tctggagtga gtggagccaa cctatttatg tggggttctc aagataaagg 1261 agataacatc cagctttcct gccccacacc gtatctgaaa taaaaacaac agcagggata 1321 gcagatt (2) INFORMATION FOR SEQ ID NO:2551: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1621 base pairs (B) TYPE: nucleic acid (C) STRP.NDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2551: 1 ccgctgcttc tcatcgcatg gccaccgcat ttctcaggcc aggcacattg agcattggtc 61 ctgtgcctga cgctatgcta gatgctgggg ttgcagccac gagcatagac acgacagaca 121 cggtcctcgc catcttctgt tgagtactgg tcggaacaag aggatcgtct gtagacaggc 181 tacagattgt tttagattga agtttcctgt catgttcact catctttaaa tcctcatagt 241 aaaaaggata tgatcatcgt ggcgcatgta ttactcatcc ttttgggggc cactgagata 301 ctgcaagctg acttacttcc tgatgaaaag atttcacttc tcccacctgt caatttcacc 361 attaaagtta ctqgtttggc tcaagttctt ttacaatgga aaccaaatcc tgatcaagag 421 caaaggaatg ttaatctaga atatcaagtg aaaataaacg ctccaaaaga agatgactat 481 gaaaccagaa tcactgaaag caaatgtgta accatcctcc acaaaggctt ttcagcaagt 541 gtgcggacca tcctgcagaa cgaccactca ctactggcca gcagctgggc ttctgctgaa 601 cttcatgccc caccagggtc tcctggaacc tcaattgtga atttaacttg caccacaaac 661 actacagaag acaattattc acgtttaagg tcataccaag tttcccttca ctgcacctgg 721 cttgttggca cagatgcccc tgaggacacg cagtattttc tctactatag gtatggctct 781 tggactgaag aatgccaaga atacagcaaa gacacactgg ggagaaatat cgcatgctgg 841 tttcccagga cttttatcct cagcaaaggg cgtgactggc tttcggtgct tgttaacggc 901 tccagcaagc actctgctat caggcccttt gatcagctgt ttgcccttca cgccattgat 961 caaataaatc ctccactgaa tgtcacagca gagattgaag gaactcgtct ctctatccaa 1021 tgggagaaac cagtgtctgc ttttccaatc cattgctttg attatgaagt aaaaatacac 1081 aatacaagga atggatattt gcagatagaa aaattgatga ccaatgcatt catctcaata 1141 attgatgatc ttcctaagta cgatgttcaa gtgagagcag cagtgagctc catgtgcaga 1201 gaggcagggc tctggagtga gtggagccaa cctatttatg tgggtaagta gcttatgttt 1261 attttacatt ggcagccttc cttgtgatca aaaaaggtaa tcccagaaac gtacccgttc 1321 actcgtgggt cataaaatgg tttcatatct ctattgtgac taattttctc tcggtctact 1381 gccttttcaa tcaggaatag atttgccatg aagccagtga agtttttaag tgtctaggct 1441 tctcattagt gccaactctc ctagacctgg tgcctgtttt ttttccaagt tttgtttcta 1501 cttctatcca ctttttaaat taaacttttt attttgaaat aattatcaca ctcacaagct 1561 gtgggaagaa azaatagaga tcctgtgtct ctttcatcca gttttcctca agggtaacact WO 00/09525 PCTIUS99/17712 EPI-109 720 1621 cttacaaaac tatagtacaa tagtggaata gaatatttgg tgtt (2) INFORMATION FOR SEQ ID NO:2552: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1981 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2552: 1 ccgctgcttc tcatcgcatg gccaccgcat ttctcaggcc aggcacattg agcattggtc 61 ctgtgcctga cgctatgcta gatgctgggg ttgcagccac gagcatagac acgacagaca 121 cggtcctcgc catcttctgt tgagtactgg tcggaacaag aggatcgtct gtagacaggc 181 tacagattgt tttagattga agtttcctgt catgttcact catctttaaa tcctcatagt 241 aaaaaggata tgatcatcgt ggcgcatgta ttactcatcc ttttgggggc cactgagata 301 ctgcaagctg acttacttcc tgatgaaaag atttcacttc tcccacctgt caatttcacc 361 attaaagtta ctggtttggc tcaagttctt ttacaatgga aaccaaatcc tgatcaagag 421 caaaggaatg ttaatctaga atatcaagtg aaaataaacg ctccaaaaga agatgactat 481 gaaaccagaa tcactgaaag caaatgtgta accatcctcc acaaaggctt ttcagcaagt 541 gtgcggacca tcctgcagaa cgaccactca ctactggcca gcagctgggc ttctgctgaa 601 cttcatgccc caccagggtc tcctggaacc tcaattgtga atttaacttg caccacaaac 661 actacagaag acaattattc acgtttaagg tcataccaag tttcccttca ctgcacctgg 721 cttgttggca cagatgcccc tgaggacacg cagtattttc tctactatag gtatggctct 781 tggactgaag aatgccaaga atacagcaaa gacacactgg ggagaaatat cgcatgctgg 841 tttcccagga cttttatcct cagcaaaggg cgtgactggc tttcggtgct tgttaacggc 901 tccagcaagc actctgctat caggcccttt gatcagctgt ttgcccttca cgccattgat 961 caaataaatc ctccactgaa tgtcacagca gagattgaag gaactcgtct ctctatccaa 1021 tgggagaaac cagtgtctgc ttttccaatc cattgctttg attatgaagt aaaaatacac 1081 aatacaagga atggatattt gcagatagaa aaattgatga ccaatgcatt catctcaata 1141 attgatgatc tttctaagta cgatgttcaa gtgagagcag cagtgagctc catgtgcaga 1201 gaggcagggc tctggagtga gtggagccaa cctatttatg tgggaaatga tgaacacaag 1261 cccttgagag agtggtttgt cattgtgatt atggcaacca tctgcttcat cttgttaatt 1321 ctctcgctta tctgtaaaat atgtcattta tggatcaagt tgtttccacc aattccagca 1381 ccaaaaagta atatcaaaga tctctttgta accactaact atgagaaagc tgggtccagt 1441 gagacggaaa ttgaagtcat ctgttatata gagaagcctg gagttgagac cctggaggat 1501 tctgtgtttt gactgtcact ttggcatcct ctgatgaact cacacatgcc tcagtgcctc 1561 agtgaaaaga acagggatgc tggctcttgg ctaagaggtg ttcagaattt aggcaacact 1621 caatttacct gcgaagcaat acacccagac acaccagtct tgtatctctt aaaagtatgg 1681 atgcttcatc caaatcgcct cacctacagc agggaagttg actcatccaa gcattttgcc 1741 atgttttttc tccccatgcc gtacagggta gcacctcctc acctgccaat ctttgcaatt 1801 tgcttgactc acctcagact ttcattcaca acagacagct tttaaggcta acgtccagct 1861 gtatttactt ctggctgtgc cgtttggctg tttaagctgc caattgtagc actcagctac 1921 catctgagga agaaagcatt ttgcatcagc ctggagtgaa ccatgaactt ggattcaaga 1981 ctgtcttttc tatagcaa (2) INFORMATION FOR SEQ ID NO:2553: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1381 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2553: 1 gtcttttgaa aggatctgcc gctgcttctc atcgcatggc caccgcattt ctcaggccag 61 gcacattgag cattggtcct gtgcctgacg ctatgctaga tgctggggtt gcagccacga 121 gcatagacac gacagacacg gtcctcgcca tcttctgttg agtactggtc ggaacaagag 181 gatcgtctgt agacaggata tgatcatcgt ggcgcatgta ttactcatcc ttttgggggc 241 cactgagata ctgcaagctg acttacttcc tgatgaaaag atttcacttc tcccacctgt 301 caatttcacc attaaagtta ctggtttggc tcaagttctt ttacaatgga aaccaaatcc 361 tgatcaagag caaaggaatg ttaatctaga atatcaagtg aaaataaacg ctccaaaaga 421 agatgactat gaaaccagaa tcactgaaag caaatgtgta accatcctcc acaaaggctt 481 ttcagcaagt gtgcggacca tcctgcagaa cgaccactca ctactggcca gcagctgggc 541tttctgctgaa cttcatgccc caccagggtc tcctggaacc tcaattgtga atttaacttg 601 caccacaaac actacagaag acaattattc acgtttaagg tcataccaag tttcccttca 661 ctgcacctgg cttgttggca cagatgcccc tgaggacacg cagtattttc tctactatag 721 gtatggctct tggactgaag aatgccaaga atacagcaaa gacacactgg ggagaaatat 781 cgcatgctgg tttcccagga cttttatcct cagcaaaggg cgtgactgc ttgcggtgct 841 tgttaacggc tccagcaagc actctgctat caggcccttt gatcagctgt ttgcccttca 901 cgccattgat caaataaatc ctccactgaa tgtcacagca gagattgaag gaactcgtct 961 ctctatccaa tgggagaaac cagtgtctgc ttttccaatc cattgctttg attatgaagt 1021 aaaaatacac aatacaagga atggatattt gcagatagaa aaattgatga ccaatgcatt WO 00/09525 PCT/US99/17712 EPI-109 721 1081 catctcaata attgatgatc tttctaagta cgatgttcaa gtgagaacag cagtgagctc 1141 catgtgcaga gaggcagggc tctggagtga gtggagccaa cctatttatg tgggtaagta 1201 gcttatgttt attttacatt ggcagccttc cttgtgatca aaaaaggraa tcccagaaac 1261 gtacccgttc actcgtgggt cttaaaatgg tttcatatct ctattgtgac taattttctc 1321 tcggtctact gccttttcaa tcaggaatag atttgccatg aagccagtga agtttttaag 1381 tgtctaggct tctcattagc gccac (2) INFORMATION FOR SEQ ID NO:2554: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1981 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2554: 1 cggtcctcgc catcttctgt tgagtactgg tcggaacaag aggatcgtct gtagacagga 61 tatgatcatc gtggcgcatg tattactcat ccttttgggg gccactgaga tactgcaagc 121 tgacttactt cctgatgaaa agatttcact tctcccacct gtcaatttca ccattaaagt 181 tactggtttg gctcaagttc ttttacaatg gaaaccaaat cctgatcaag agcaaaggaa 241 tgttaatcta gaatatcaag tgaaaataaa cgctccaaaa gaagatgact atgaaaccag 301 aatcactgaa agcaaatgtg taaccatcct ccacaaaggc ttttcagcaa gtgtgcggac 361 catcctgcag aacgaccact cactactggc cagcagctgg gcttctgctg aacttcatgc 421 cccaccaggg tctcctggaa cctcagttgt gaatttaact tgcaccacaa acactacaga 481 agacaattat tcacgtttaa ggtcatacca agtttccctt cactgcacct ggcttgttgg 541 cacagatgcc cctgaggaca cgcagtattt tctctactat aggtatggct cttggactga 601 agaatgccaa gaatacagca aagacacact ggggagaaat atcgcatgct ggtttcccag 661 gacttttatc ctcagcaaag ggcgtgactg gcttgcggtg cttgttaacg gctccagcaa 721 gcactctgct atcaggccct ttgatcagct gtttgccctt cacgccattg atcaaataaa 781 tcctccactg aatgtcacag cagagattga aggaactcgt ctctctatcc aatgggagaa 841 accagtgtct gcttttccaa tccattgctt tgattatgaa gtaaaaatac acaatacaag 901 gaatggatat ttgcagatag aaaaattgat gaccaatgca ttcatctcaa taattgatga 961 tctttctaag tacgatgttc aagtgagagc agcagtgagc tccatgtgca gagaggcagg 1021 gctctggagt gagtggagcc aacctattta tgtgggaaat gatgaacaca agcccttgag 1081 agagtggttt gtcattgtga ttatggcaac catctgcttc atcttgttaa ttctctcgct 1141 tatctgtaaa atatgtcatt tatggatcaa gttgtttcca ccaattccag caccaaaaag 1201 taatatcaaa gatctctttg taaccactaa ctatgagaaa gctgggtcca gtgagacgga 1261 aattgaagtc atctgttata tagagaagcc tggagttgag accctggagg attctgtgtt 1321 ttgactgtca ctttggcatc ctctgatgaa ctcacacatg cctcagtgcc tcagtgaaaa 1381 gaacagggat gctggctctt ggctaagagg tgttcagaat ttaggcaaca ctcaatttac 1441 ctgcgaagca atacacccag acacaccagt cttgtatctc ttaaaagtat ggatgcttca 1501 tccaaatcgc ctcacctaca gcagggaagt tgactcatcc aagcattttg ccatgttttt 1561 tctccccatg ccgtacaggg tagcacctcc tcacctgcca atctttgcaa tttgcttgac 1621 tcacctcaga cttttcattc acaacagaca gcttttaagg ctaacgtcca gctgtattta 1681 cttctggctg tgcccgtttg gctgtttaag ctgccaattg tagcactcag ctaccatctg 1741 aggaagaaag cattttgcat cagcctggag tgaatcatga acttggattc aagactgtct 1801 tttctatagc aagtgagagc cacaaattcc tcacccccct acattctaga atgatctttt 1861 tctaggtaga ttgtgtatgt gtgtgtatga gagagagaga gagagagaga gagagagaga 1921 gagaaattat ctcaagctcc agaggcctga tccaggatac atcatttgaa accaactaat 1981 ttaaaagcat aatagagcta atatat (2) INFORMATION FOR SEQ ID NO:2555: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 11167 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2555: 1 tagatgctgg ggttgcagcc acgagcatag acacgacaga cacggtcctc gccatcttct 61 gttgagtact ggtcggaaca agaggatcgt ctgtagacag gatatgatca tcgtggcgca 121 tgtattactc atccttttgg gggccactga gatactgcaa gctgacttac ttcctgatga 181 aaagatttca cttctcccac ctgtcaattt caccattaaa gttactggtt tggctcaagt 241 tcttttacaa tggaaaccaa atcctgatca agagcaaagg aatgttaatc tagaatatca 301 agtgaaaata aacgctccaa aagaagatga ctatgaaacc agaatcactg aaagcaaatg 361 tgtaaccatc ctccacaaag gcttttcagc aagtgtgcgg accatcctgc agaacgacca 421 ctcactactg gccagcagct gggcttctgc tgaacttcat gccccaccag ggtctcctgg 481 aacctcaatt gtgaatttaa cttgcaccac aaacactaca gaagacaatt attcacgttt 541 aaggtcatac caagtttccc ttcactgcac ctggcttgtt ggcacagatg cccctgagga 601 cacgcagtat tttctctact ataggtatgg ctcttggact gaagaatgcc aagaatacag 661 caaagacaca ctggggagaa atatcgcatg ctggtttccc aggactttta tcctcagcaa 721 agggcgtgac tggcttgcgg tgcttgttaa cggctccagc aagcactctg ctatcaggcc WO 00/09525 PCTIUS99/17712 EPI-109 722 781 ctttgatcag ctgtttaccc ttcacgccat tgatcaaata aatcctccac tgaatgtcac 841 agcagagatt gaaggaactc gtctctctat ccaatgggag aaaccagtgt ctgcttttcc 901 aatccattgc tttgattatg aagtaaaaat acacaataca aggaatggat atttgcagat 961 agaaaaattg atgaccaatg cattcatctc aataattgat gatctttcta agtacgatgt 1021 tcaagtgaga gcagcagtga gctccatgtg cagagaggca gggctctgga gtgagtggag 1081 ccaacctatt tatgtgggaa atgatgaaca caagcccttg agagagtggt ttgtcattgt 1141 gattatggca accatctgct tcatcttgtt aattctctcg cttatctgta aaatatgtca 1201 tttatggatc aagttgtttc caccaattcc agcaccaaaa agtaatatca aagatctctt 1261 tgtaaccact aactatgaga aagctggaat ttaaattcaa gcatgtttta acttttggtt 1321 taaggtactt gggtgtacct ggcagtgttg taagctcttt acattaatta attaactctc 1381 taggtactgt tatcttcatt ttataaacaa ggcagctgaa gttgagagaa ataagtaacc 1441 tgtcctaggt cacacaatta ggaaatgaca gatctggcag tctatttcca ggcagtctat 1501 ttccacgagg tcatgagtgc gaaagaggga ctaggggaag aatgattaac tccagggagc 1561 tgacttttct agtgtgctta cctgttttgc atctctcaag gatgtgccat gaagctgtag 1621 ccaggtggaa ttgtaccaca gccctgacat gaacacctga tggcagctgc tgggttggag 1681 cctagacaaa aacatgaaga accatggctg ctgcctgagc ccatcgtgct gtaattatag 1741 aaaaccttct aagggaagaa tatgctgata tttttcagat aagtacccct tttataaaaa 1801 tcctccaagt tagccctcga ttttccatgt aaggaaacag aggctttgag ataatgtctg 1861 tctcctaagg gacaaagcca ggacttgatc ctgtcttaaa aatgcaaaat gtagtacttc 1921 ttccatcaaa ggtagacatg cactaaggga caggttttgg cttggtatca gaatacattt 1981 ttaaaagctg tgtaagaatt gaacgggctg tactaggggg tata 1 gatctttcta agtacgatgt tcaagtgaga gcagcagtga gctccatgtg cagagaggca 61 gggctctgga gtgagtggag ccaacctatt tatgtgggaa atgatgaaca caagcccttg 121 agagagtggt ttgtcattgi gattatggca accatctgct tcatcttgtt aattctctcg 181 cttatctgta aaatatgtca tttatggatc aagttgtttc caccaattcc agcaccaaaa 241 agtaatatca aagatctctt tgtaaccact aactatgagg tcctctgcat tttcatatac 301 atcttagatt cggctgacaa ttttctacaa aaaaagaaag ctgggtccag tgagacggaa 361 attgaagtca tctgttatat agagaagcct ggagttgaga ccctggagga ttctgtgttt 421 tgactgtcac tttggcatcc tctgatgaac tcacacatgc ctcagtgcct cagtgaaaag 481 aacagggatg ctggctcttg gctaagaggt gttcagaatt taggcaacac tcaatttacc 541 tgcgaagcaa tacacccaga cacaccagtc ttgtatctct taaaagtatg gatgcttcat 601 ccaaatcgcc tcacctacag cagggaagtt gactcatcca agcattttgc catgtttttt 661 ctccccatgc cgtacagggt agcacctcct cacctgccaa tctttgcaat ttgcttgact 721 cacctcagac ttttcattca caacagacag cttttaaggc taacgtccag ctgtatttac 781 ttctggctgt gcccgtttgg ctgtttaagc tgccaattgt agcactcagc taccatctga 841 ggaagaaagc attttgcatc agcctggagt gaaccatgaa cttggattca agactgtctt 901 ttctatagca agtgagagcc acaaattcct c 1 ccgctgcttc tcatcgcatg gccaccgcat ttctcaggcc aggcacattg agcattggtc 61 ctgtgcctga cgctatgcta gatgctgggg ttgcagccac gagcatagac acgacagaca 121 cggtcctcgc catcttctgt tgagtactgg tcggaacaag aggatcgtct gtagacaggc 181 tacagattgt tttagattga agtttcctgt catgttcact catctttaaa tcctcatagt 241 aaaaaggata tgatcatcgt ggcgcatgta ttactcatcc ttttgggggc cactgagata 301 ctgcaagctg acttacttcc tgatgaaaag atttcacttc tcccacctgt caatttcacc 361 attaaagtta ctggtttggc tcaagttctt ttacaatgga aaccaaatcc tgatcaagag 421 caaaggaatg ttaatctaga atatcaagtg aaaataaacg ctccaaaaga agatgactat 481 gaaaccagaa tcactgaaag caaatgtgta accatcctcc acaaaggctt ttcagcaagt 541 gtgcggacca tcctgcagaa cgaccactca ctactggcca gcagctgggc ttctgctgaa 601 cttcatgccc caccagggtc tcctggaacc tcaattgtga atttaacttg caccacaaac 661 actacagaag acaattattc acgtttaagg tcataccaag tttcccttca ctgcacctgg 721 cttgttggca cagatgcccc tgaggacacg cagtattttc tctactatag gtatggctct 781 tggactgaag aatgccaaga atacagcaaa gacacactgg ggagaaatat cgcatgctgg 841 tttcccagga cttttatcct cagcaaaggg cgtgactggc tttcggtgct tgttaacggc 901 tccagcaagc actctgctat caggcccttt gatcagctgt ttgcccttca cgccattgat 961 caaataaatc ctccactgaa tgtcacagca gagattgaag gaactcgtct ctctatccaa 1021 tgggagaaac cagtgtctgc ttttccaatc cattgctttg attatgaagt aaaaatacac 1081 aatacaagga atggatattt gcagatagaa aaattgatga ccaatgcatt catctcaata 1141 attgatgatc tttctaagta cgatgttcaa gtgagagcag cagtgagctc catgtgcaga 1201 gaggcagggc tctggagtga gtggagccaa cctatttatg tggggttctc aagataaagg 1261 agataacatc cagctttcct gccccacacc gtatctgaaa taaaaacaac agcagggata 1321 gcagatt 1 ccgctgcttc tcatcgcatg gccaccgcat ttctcaggcc aggcacattg agcattggtc 61 ctgtgcctga cgctatgcta gatgctgggg ttgcagccac gagcatagac acgacagaca 121 cggtcctcgc catcttctgt tgagtactgg tcggaacaag aggatcgtct gtagacaggc 181 tacagattgt tttagattga agtttcctgt catgttcact catctttaaa tcctcatagt 241 aaaaaggata tgatcatcgt ggcgcatgta ttactcatcc ttttgggggc cactgagata 301 ctgcaagctg acttacttcc tgatgaaaag atttcacttc tcccacctgt caatttcacc 361 attaaagtta ctggtttggc tcaagttctt ttacaatgga aaccaaatcc tgatcaagag 421 caaaggaatg ttaatctaga atatcaagtg aaaazaaacg ctccaaaaga agatgactat WO 00/09525 PCT/US99/17712 EPI-109 723 481 gaaaccaaaa tcactgaaag caaatgtgta accatcctcc acaaaggctt ttcagcaagt 541 gtgcggacca tcctgcagaa cgaccactca ctactggcca gcagctgggc ttctgctgaa 601 cttcatgccc caccagggtc tcctggaacc tcaattgtga atttaacttg caccacaaac 661 actacaqaag acaattattc acgtttaagg tcataccaag tttcccttca ctgcacctgg 721 cttgttggca cagatgcccc tgaggacacg cagtattttc tctactatag gtatggctct 781 tggactgaag aatgccaaga atacagcaaa gacacactgg ggagaaatat cgcatgctgg 841 tttcccagga cttttatcct cagcaaaggg cgtgactggc tttcggtgct tgttaacggc 901 tccagcaagc actctgctat caggcccttt gatcagctgt ttgcccttca cgccattqat 961 caaataaatc ctccactgaa tgtcacagca gagattgaag gaactcgtct ctctatccaa 1021 tgggagaaac cagtgtctgc ttttccaatc cattgctttg attatgaagt aaaaatacac 1081 aatacaagga atggatattt gcagatagaa aaattgatga ccaatgcatt catctcaata 1141 attgatgatc tttctaagta cgatgttcaa gtgagagcag cagtgagctc catgtgcaga 1201 gaggcagggc tctggagtga gtggagccaa cctatttatg tgggtaagta gcttatgttt 1261 attttacatt ggcagccttc cttgtgatca aaaaaggtaa tcccagaaac gtacccgttc 1321 actcgtgggt cttaaaatgg tttcatatct ctattgtgac taattttctc tcggtctact 1381 gccttttcaa tcaggaatag atttgccatg aagccagtga agtttttaag tgtctaggct 1441 tctcattagt gccaactctc ctagacctgg tgcctgtttt ttttccaagt tttgtttcta 1501 cttctatcca ttttttaaat taaacttttt attttgaaat aattatcaca ctcacaagct 1561 gtgggaagaa ataatagaga tcctgtgtct ctttcatcca gttttcctca agggtaacat 1621 cttacaaaac tatagtacaa tagtggaata gaatatttgg tgtt 1 ccgctgcttc tcatcgcatg gccaccgcat ttctcaggcc aggcacattg agcattggtc 61 ctgtgcctga cgctatgcta gatgctgggg ttgcagccac gagcatagac acgacagaca 121 cggtcctcgc catcttctgt tgagtactgg tcggaacaag aggatcgtct gtagacaggc 181 tacagattgt tttagattga agtttcctgt catgttcact catctttaaa tcctcatagt 241 aaaaaggata tgatcatcgt ggcgcatgta ttactcatcc ttttgggggc cactgagata 301 ctgcaagctg acttacttcc tgatgaaaag atttcacttc tcccacctgt caatttcacc 361 attaaagtta ctggtttggc tcaagttctt ttacaatgga aaccaaatcc tgatcaagag 421 caaaggaatg ttaatctaga atatcaagtg aaaataaacg ctccaaaaga agatgactat 481 gaaaccagaa tcactgaaag caaatgtgta accatcctcc acaaaggctt ttcagcaagt 541 gtgcggacca tcctgcagaa cgaccactca ctactggcca gcagctgggc ttctgctgaa 601 cttcatgccc caccagggtc tcctggaacc tcaattgtga atttaacttg caccacaaac 661 actacagaag acaattattc acgtttaagg tcataccaag tttcccttca ctgcacctgg 721 cttgttggca cagatgcccc tgaggacacg cagtattttc tctactatag gtatggctct 781 tggactgaag aatgccaaga atacagcaaa gacacactgg ggagaaatat cgcatgctgg 841 tttcccagga cttttatcct cagcaaaggg cgtgactggc tttcggtgct tgttaacggc 901 tccagcaagc actctgctat caggcccttt gatcagctgt ttgcccttca cgccattgat 961 caaataaatc ctccactgaa tgtcacagca gagattgaag gaactcgtct ctctatccaa 1021 tgggagaaac cagtgtctgc ttttccaatc cattgctttg attatgaagt aaaaatacac 1081 aatacaagga atggatattt gcagatagaa aaattgatga ccaatgcatt catctcaata 1141 attgatgatc tttctaagta cgatgttcaa gtgagagcag cagtgagctc catgtgcaga 1201 gaggcagggc tctggagtga gtggagccaa cctatttatg tgggaaatga tgaacacaag 1261 cccttgagag agtggtttgt cattgtgatt atggcaacca tctgcttcat cttgttaatt 1321 ctctcgctta tctgtaaaat atgtcattta tggatcaagt tgtttccacc aattccagca 1381 ccaaaaagta atatcaaaga tctctttgta accactaact atgagaaagc tgggtccagt 1441 gagacggaaa ttgaagtcat ctgttatata gagaagcctg gagttgagac cctggaggat 1501 tctgtgtttt gactgtcact ttggcatcct ctgatgaact cacacatgcc tcagtgcctc 1561 agtgaaaaga acagggatgc tggctcttgg ctaagaggtg ttcagaattt aggcaacact 1621 caatttacct gcgaagcaat acacccagac acaccagtct tgtatctctt aaaagtatgg 1681 atgcttcatc caaatcgcct cacctacagc agggaagttg actcatccaa gcattttgcc 1741 atgttttttc tccccatgcc gtacagggta gcacctcctc acctgccaat ctttgcaatt 1801 tgcttgactc acctcagact ttcattcaca acagacagct tttaaggcta acgtccagct 1861 gtatttactt ctggctgtgc cgtttggctg tttaagctgc caattgtagc actcagctac 1921 catctgagga agaaagcatt ttgcatcagc ctggagtgaa ccatgaactt ggattcaaga 1981 ctgtcttttc tatagcaa 1 gtcttttgaa aggatctgcc gctgcttctc atcgcatggc caccgcattt ctcaggccag 61 gcacattgag cattggtcct gtgcctgacg ctatgctaga tgctggggtt gcagccacga 121 gcatagacac gacagacacg gtcctcgcca tcttctgttg agtactggtc ggaacaagag 181 gatcgtctgt agacaggata tgatcatcgt ggcgcatgta ttactcatcc ttttgggggc 241 cactgagata ctgcaagctg acttacttcc tgatgaaaag atttcacttc tcccacctgt 301 caatttcacc attaaagtta ctggtttggc tcaagttctt ttacaatgga aaccaaatcc 361 tgatcaagag caaaggaatg ttaatctaga atatcaagtg aaaataaacg ctccaaaaga 421 agatgactat gaaaccagaa tcactgaaag caaatgtgta accatcctcc acaaaggctt 481 ttcagcaagt gtgcggacca tcctgcagaa cgaccactca ctactggcca gcagctgggc 541 ttctgctgaa cttcatgccc caccagggtc tcctggaacc tcaattgtga atttaacttg 601 caccacaaac actacagaag acaattattc acgtttaagg tcataccaag tttcccttca 661 ctgcacctgg cttgttggca cagatgcccc tgaggacacg cagtattttc tctactatag 721 gtatggctct tggactgaag aatgccaaga atacagcaaa gacacactgg ggagaaatat 781 cgcatgctgg tttcccagga cttttatcct cagcaaaggg cgtgactggc ttgcggtgct WO 00/09525 PCT/US99/17712 EPI-109 724 841 tgttaacggc tccagcaaqc actctgctat caggcccttt gatcagctgt ttgcccttca 901 cgccattgat caaataaatc ctccactgaa tgtcacagca gagattaag gaactcgtct 961 ctctatccaa tgggagaaac cagtgtctgc ttttccaatc cattgctttg attatgaagt 1021 aaaaatacac aatacaagga atggatattt gcagatagaa aaattgatga ccaatgcatt 1081 catctcaata attgatgatc tttctaagta cgatgttcaa gtgagaacag cagtgagctc 1141 catgtgcaga gaggcagggc tctggagtga gtggagccaa cctatttatg tgggtaagta 1201 gcttatgttt attttacatt ggcagccttc cttgtgatca aaaaaggtaa tcccagaaac 1261 gtacccgttc actcgtgggt cttaaaatgg tttcatatct ctattgtgac taattttctc 1321 tcggtctact gccttttcaa tcaggaatag atttgccatg aagccagtga agtttttaag 1381 tgtctaggct tctcattagc gccac 1 cggtcctcgc catcttctgt tgagtactgg tcggaacaag aggatcatct gtagacagga 61 tatgatcatc gtggcgcatg tattactcat ccttttgggg gccactgaga tactgcaagc 121 tgacttactt cctgatgaaa agatttcact tctcccacct gtcaatttca ccattaaagt 181 tactggtttg gctcaagttc ttttacaatg gaaaccaaat cctgatcaag agcaaaggaa 241 tgttaatcta gaatatcaag tgaaaataaa cgctccaaaa gaagatgact atgaaaccag 301 aatcactgaa agcaaatgtg taaccatcct ccacaaaggc ttttcagcaa gtgtgcggac 361 catcctgcag aacgaccact cactactggc cagcagctgg gcttctgctg aacttcatgc 421 cccaccaggg tctcctggaa cctcagttgt gaatttaact tgcaccacaa acactacaga 481 agacaattat tcacgtttaa ggtcatacca agtttccctt cactgcacct ggcttgttgg 541 cacagatgcc cctgaggaca cgcagtattt tctctactat aggtatggct cttggactga 601 agaatgccaa gaatacagca aagacacact ggggagaaat atcgcatgct ggtttcccag 661 gacttttatc ctcagcaaag ggcgtgactg gcttgcggtg cttgttaacg gctccagcaa 721 gcactctgct atcaggccct ttgatcagct gtttgccctt cacgccattg atcaaataaa 781 tcctccactg aatgtcacag cagagattga aggaactcgt ctctctatcc aatgggagaa 841 accagtgtct gcttttccaa tccattgctt tgattatgaa gtaaaaatac acaatacaag 901 gaatggatat ttgcagatag aaaaattgat gaccaatgca ttcatctcaa taattgatga 961 tctttctaag tacgatgttc aagtgagagc agcagtgagc tccatgtgca gagaggcagg 1021 gctctggagt gagtggagcc aacctattta tgtgggaaat gatgaacaca agcccttgag 1081 agagtggttt gtcattgtga ttatggcaac catctgcttc atcttgttaa ttctctcgct 1141 tatctgtaaa atatgtcatt tatggatcaa gttgtttcca ccaattccag caccaaaaag 1201 taatatcaaa gatctctttg taaccactaa ctatgagaaa gctgggtcca gtgagacgga 1261 aattgaagtc atctgttata tagagaagcc tggagttgag accctggagg attctgtgtt 1321 ttgactgtca ctttggcatc ctctgatgaa ctcacacatg cctcagtgcc tcagtgaaaa 1381 gaacagggat gctggctctt ggctaagagg tgttcagaat ttaggcaaca ctcaatttac 1441 ctgcgaagca atacacccag acacaccagt cttgtatctc ttaaaagtat ggatgcttca 1501 tccaaatcgc ctcacctaca gcagggaagt tgactcatcc aagcattttg ccatgttttt 1561 tctccccatg ccgtacaggg tagcacctcc tcacctgcca atctttgcaa tttgcttgac 1621 tcacctcaga cttttcattc acaacagaca gcttttaagg ctaacgtcca gctgtattta 1681 cttctggctg tgcccgtttg gctgtttaag ctgccaattg tagcactcag ctaccatctg 1741 aggaagaaag cattttgcat cagcctggag tgaatcatga acttggattc aagactgtct 1801 tttctatagc aagtgagagc cacaaattcc tcacccccct acattctaga atgatctttt 1861 tctaggtaga ttgtgtatgt gtgtgtatga gagagagaga gagagagaga gagagagaga 1921 gagaaattat ctcaagctcc agaggcctga tccaggatac atcatt.gaa acCaactaat 1981 ttaaaagcat aatagagcta atatat (2) INFORMATION FOR SEQ ID NO:2556: (1) SEQUENCE CHARACTERISTICS: (A) LENGTH: 5161 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2556: 1 gaattcagta acccaggcat tattttatcc tcaagtctta ggttggttgg agaaagataa 61 caaaaagaaa catgattgtg cagaaacaga caaacctttt tggaaagcat ttgaaaatgg 121 cattccccct ccacagtgtg ttcacagtgt gggcaaattc actgctctgt cgtactttct 181 gaaaatgaag aactgttaca ccaaggtgaa ttatttataa attatgtact tgcccagaag 241 cgaacagact tttactatca taagaaccct tccttggtgt gctctttatc tacagaatcc 301 aagacctttc aagaaaggtc ttggattctt ttcttcagga cactaggaca taaagccacc 361 tttttatgat ttgttgaaat ttctcactcc atcccttttg ctgatgatca tgggtcctca 421 gaggtcagac ttggtgtcct tggataaaga gcatgaagca acagtggctg aaccagagtt 481 ggaacccaga tgctctttcc actaagcata caactttcca ttagaaaca cctccctccc 541 accccaacca agcagctcca gtgcaccact ttctggagca taaacatacc ttaactttac 601 aacttgagtg gccttgaata ctgttcctat ctggaatgtg ctgttctctt tcatcttcct 661 ctattgaagc cctcctattc ctcaatgcct tgctccaact gcctttggaa gattctgctc 721 ttatgcctcc actggaatta atgtcttagt accacttgtc tattctgcta tatagtcagt 781 ccttacattg ctttcttctt ctgatagacc aaactcttta aggacaagta ccagtctta 841 tctatttcta gatcccccac attactcaga aagttactcc ataaatgttt gtggaactga 901 tttctatgtg aagacatgtg ccccttcact ctgttaacta gcattaaaaa aacaaatctt 961 ttgaaaagtt gtagtatgcc cctaagagca gtaacagttc ctagaaactc tctaaaatgc WO 00/09525 PCTIUS99/17712 EPI-109 725 1021 ttagaaaaag atttatttta aattacctcc ccaataaaat gattggctgg cttatcttca 1081 ccatcatgat agcatctgta attaactgaa aaaaaataat tatgccatta aaagaaaatc 1141 atccatgatc ttgttctaac acctgccact ctagtactat atctgtcaca tggtctatga 1201 taaagttatc tagaaataaa aaagcataca attgataatt caccaaattg tggagcttca 1261 gtattttaaa tgtatattaa aattaaatta ttttaaagat caaagaaaac tttcgtcata 1321 ctccgtattt gataaggaac aaataggaag tgtgatgact caggtttgcc ctgaggggat 1381 gggccatcag ttgcaaatcg tggaatttcc tctgacataa tgaaaagatg agggtgcata 1441 agttctctag tagggtgatg atataaaaag ccaccggagc actccataag gcacaaactt 1501 tcagagacag cagagcacac aagcttctag gacaagagcc aggaagaaac caccggaagg 1561 aaccattctc actgtgtgta aacatgactt ccaagctggc cgtggctctc ttggcagcct 1621 tcctgatttc tgcagctctg tgtgaaggta agcacatctt tctgacctac agcgttttcc 1681 tatgtctaaa tgtgatcctt agatagcaaa gctattcttg atgctttggt aacaaacatc 1741 ctttttattc agaaacagaa tataatctta gcagtcaatt aatgttaaat tgaagattta 1801 gaaaaaacta tatataacac ttaggaaata taaaggtttg atcaatatag atattctgct 1861 tttataattt ataccaggta gcatgcatat atttaacgta aataagtaat ttatagtatg 1921 tcctattgag aaccacggtt acctatatta tgtattaata ttgagttgag caaggtaact 1981 cagacaattc cactccttgt agtatttcat tgacaagcct cagatttgtc attaattcct 2041 gtctggttta aagataccct gattatagac caggcatgta taacttattt atatatttct 2101 gttaattctt tctgaaggca atttctatgc tggagagtct tagcttgcct actataaata 2161 acactgtggt atcacagagg attatgcaat attgaccaga taaaaatacc atgaagatgt 2221 tgatattgta caaaaagaac tctaactctt atataggaag ttgttcaatg ttgtcagtta 2281 tgactgtttt ttaaaacaaa gaactaactg aggtcaaggg ctaggagata ttcaggaatg 2341 agttcactag aaacatgatg ccttccatag tctccaaata atcatattgg aattagaagg 2401 aagtagctgg cagagctgtg cctgttgata aaatcaatcc ttaatcactt tttcccccaa 2461 caggtgcagt tttgccaagg agtgctaaag aacttagatg tcagtgcata aagacatact 2521 ccaaaccttt ccaccccaaa tttatcaaag aactgagagt gattgagagt ggaccacact 2581 gcgccaacac agaaattatg taagtacttt aaaaaagatt agatattttg ttttagcaaa 2641 cttaaaatta aggaaggtgg aaatatttag gaaagttcca ggtgttagga ttacagtagt 2701 aaatgaaaca aaacaaaata aaaatatttg tctacatgac atttaaatat ggtagcttcc 2761 acaactacta taaatgttat tttggactta gactttatgc ctgacttaag gaatcatgat 2821 ttgaatgcaa aaactaaata ttaatctgaa ccatttcttt cttatttcag tgtaaagctt 2881 tctgatggaa gagagctctg tctggacccc aaggaaaact gggtgcagag ggttgtggag 2941 aagtttttga agaggtaagt tatatatttt ttaatttaaa tttttcattt atcctgagac 3001 atataatcca aagtcagcct ataaatttct ttctgttgct aaaaatcgtc attaggtatc 3061 tgcctttttg gttaaaaaaa aaggaatagc atcaatagtg agtttgttgt acttatgacc 3121 agaaagacca tacatagttt gcccaggaaa ttctgggttt aagcttgtgt cctatactct 3181 tagtaaagtt ctttgtcact cccagtagtg tcctatttta gatgataatt tctttgatct 3241 ccctatttat agttgagaat atagagcatt tctaacacat gaatgtcaaa gactatattg 3301 acttttcaag aaccctactt tccttcttat taaacatagc tcatctttat atttttaatt 3361 ttattttagg gctgagaatt cataaaaaaa ttcattctct gtggtatcca agaatcagtg 3421 aagatgccag tgaaacttca agcaaatcta cttcaacact tcatgtattg tgtgggtctg 3481 ttgtagggtt gccagatgca atacaagatt cctggttaaa tttgaatttc agtaaacaat 3541 gaatagtttt tcattgtacc atgaaatatc cagaacatac ttatatgtaa agtattattt 3601 atttgaatct acaaaaaaca acaaataatt tttaaatata aggattttcc tagatattgc 3661 acgggagaat atacaaatag caaaattggg ccaagggcca agagaatatc cgaactttaa 3721 tttcaggaat tgaatgggtt tgctagaatg tgatatttga agcatcacat aaaaatgatg 3781 ggacaataaa ttttgccata aagtcaaatt tagctggaaa tcctggattt ttttctgtta 3841 aatctggcaa ccctagtctg ctagccagga tccacaagtc cttgttccac tgtgccttgg 3901 tttctccttt atttctaagt ggaaaaagta ttagccacca tcttacctca cagtgatgtt 3961 gtgaggacat gtggaagcat tttaagtttt ttcatcataa cataaattat tttcaagtgt 4021 aacttattaa cctatttatt atttatgtat ttatttaagc atcaaatatt tgtgcaagaa 4081 tttggaaaaa tagaagatga atcattgatt gaatagttat aaagatgtta tagtaaattt 4141 attttatttt agatattaaa tgatgtttta ttagataaat ttcaatcagg gtttttagat 4201 taaacaaaca aacaattggg tacccagtta aattttcatt tcagatatac aacaaataat 4261 tttttagtat aagtacatta ttgtttatct gaaattttaa ttgaactaac aatcctagtt 4321 tgatactccc agtcttgtca ttgccagctg tgttggtagt gctgtgttga attacggaat 4381 aatgagttag aactattaaa acagccaaaa ctccacagtc aatattagta atttcttgct 4441 ggttgaaact tgtttattat gtacaaatag attcttataa tattatttaa atgactgcat 4501 ttttaaatac aaggctttat atttttaact ttagtgtttt tatgtgctct ccaaattttt 4561 tttactgttt ctgattgtat ggaaatataa aagtaaatat gaaacattta aaatataatt 4621 tgttgtcaaa gtaatcaagt gtttgtcttt tttttagttt tagcttattg ggattctctt 4681 tgtttatatt taaaattata ctttgattta gaaaacataa atgcttcccc ttagcatttt 4741 gttatggaaa attacaaact tttattttta gaaaacagaa ctcctttcca gaaataggtt 4801 acaaacagta gtgtcctcca cagaatgttg gaaatgtttt caactcccca ctgtatacta 4861 tcttgctaat aagtctgtct tcagatttcg attaaccggt ttgtatgtct gtgcacttta 4921 gcatagctgg acattaaaga ggaaagagag tacatattat aagttgctta tcagtaactg 4981 aggagtaaaa ctgataaatg tgaggcaaag aagtttaaaa tatggttaaa gcctaagcat 5041 atttgcaaac aaatcaaaca atactctgag aagtaaaaac ataattatt aattaacaaa WO 00/09525 PCT/US99/17712 EPI-109 726 5101 tttcagtgga taaattttan aacaaattag acacagttga aaataaaatt agaaaactag 5161 aaaatagaac aaaagaaact tctggaattc a (2) INFORMATION FOR SEQ ID NO:2557: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1981 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2557: 1 tattcatcaa gtgccctcta gctgttaagt cactctgatc tctgactgca gctcctactg 61 ttggacacac ctggccggtg cttcagttag atcaaaccat tgctgaaact gaagaggaca 121 tgtcaaatat tacagatcca cagatgtggg attttgatga tctaaatttc actggcatgc 181 cacctgcaga tgaagattac agcccctgta tgctagaaac tgagacactc aacaagtatg 241 ttgtgatcat cgcctatgcc ctagtgttcc tgctgagcct gctgggaaac tccctggtga 301 tgctggtcat cttatacagc agggtcggcc gctccgtcac tgatgtctac ctgctgaacc 361 tggccttggc cgacctactc tttgccctga ccttgcccat ctgggccgcc tccaaggtga 421 atggctggat ttttggcaca ttcctgtgca aggtggtctc actcctgaag gaagtcaact 481 tctacagtgg catcctgctg ttggcctgca tcagtgtgga ccgttacctg gccattgtcc 541 atgccacacg cacactgacc cagaagcgtc acttggtcaa gtttgtttgt cttggctgct 601 ggggactgtc tatgaatctg tccctgccct tcttcctttt ccgccaggct taccatccaa 661 acaattccag tccagtttgc tatgaggtcc tgggaaatga cacagcaaaa tggcggatgg 721 tgttgcggat cctgcctcac acctttggct tcatcgtgcc gctgtttgtc atgctgttct 781 gctatggatt caccctgcgt acactgttta aggcccacat ggggcagaag caccgagcca 841 tgagggtcat ctttgctgtc gtcctcatct tcctgctttg ctggctgccc tacaacctgg 901 tcctgctggc agacaccctc atgaggaccc aggtgatcca ggagagctgt gagcgccgca 961 acaacatcgg ccgggccctg gatgccactg agattctggg atttctccat agctgcctca 1021 accccatcat ctacgccttc atcggccaaa attttcgcca tggattcctc aagatcctgg 1081 ctatgcatgg cctggtcagc aaggagttct tggcacgtca tcgtgttacc tcctacactt 1141 cttcgtctgt caatgtctct tccaacctct gaaaaccatc gatgaaggaa tatctcttct 1201 cagaaggaaa gaataaccaa caccctgagg ttgtgtgtgg aaggtgatct ggctctggac 1261 aggcactatc tgggttttgg ggggacgcta taggatgtgg ggaagttagg aactggtgtc 1321 ttcaggggcc acaccaacct tctgaggagc tgttgaggta cctccaagga ccggcctttg 1381 cacctccatg gaaacgaagc accatcattc ccgttgaacg tcacatcttt aacccactaa 1441 ctggctaatt agcatggcca catctgagcc ccgaatctga cattagatga gagaacaggg 1501 ctgaagctgt gtcctcatga gggctggatg ctctcgttga ccctcacagg agcatctcct 1561 caactctgag tgttaagcgt tgagccacca agctggtggc tctgtgtgct ctgatccgag 1621 ctcagggggg tggttttccc atctcaggtg tgttgcagtg tctgctggag acattgaggc 1681 aggcactgcc aaaacatcaa cctgccagct ggccttgtga ggagctggaa acacatgttc 1741 cccttggggg tggtggatga acaaagagaa agagggtttg gaagccagat ctatgccaca 1801 agaaccccct ttacccccat gaccaacatc gcagacacat gtgctggcca cctgctgagc 1861 cccaagtgga acgagacaag cagcccttag cccttcccct ctgcagcttc caggctggcg 1921 tgcagcatca gcatccctag aaagccatgt gcagccacca gtccattggg caggcagatg 1981 ttcctaataa agcttctgtt ccgtgct (2) INFORMATION FOR SEQ ID NO:2558: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1741 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2558: 1 cctacaggtg aaaagcccag cgacccagtc aggatttaag tttacctcaa aaatggaaga 61 ttttaacatg gagagtgaca gctttgaaga tttctggaaa ggtgaagatc ttagtaatta 121 cagttacagc tctaccctgc ccccttttct actagatgcc gccccatgtg aaccagaatc 181 cctggaaatc aacaagtatt ttgtggtcat tatctatgcc ctggtattcc tgctgagcct 241 gctgggaaac tccctcgtga tgctggtcat cttatacagc agggtcggcc gctccgtcac 301 tgatgtctac ctgctgaacc tagccttggc cgacctactc tttgccctga ccttgcccat 361 ctgggccgcc tccaaggtga atggctggat ttttggcaca ttcctgtgca aggtggtctc 421 actcctgaag gaagtcaact tctatagtgg catcctgcta ctggcctgca tcagtgtgga 481 ccgttacctg gccattgtcc atgccacacg cacactgacc cagaagcgct acttggtcaa 541 attcatatgt ctcagcatct ggggtctgtc cttgctcctg gccctgcctg tcttactttt 601 ccgaaggacc gtctactcat ccaatgttag cccagcctgc tatgaggaca tgggcaacaa 661 tacagcaaac tggcggatgc tgttacggat cctgccccag tcctttggct tcatcgtgcc 721 actgctgatc atgctgttct gctacggatt caccctgcgt acgctgttta aggcccacat 781 ggggcagaag caccgggcca tgcgggtcat ctttgctgtc gtcctcatct tcctgctttg 841 ctggctgccc tacaacctgg tcctgctggc agacaccctc atgaggaccc aggtgatcca 901 ggagacctgt gagcgccgca atcacatcga ccgggctctg gatgccaccg agattctggg 961 catccttcac agctgcctca accccctcat ctacgcct c attggccaga agtttcgcca WO 00/09525 PCT/US99/17712 EPI-109 727 1021 tggactcctc aagattctag ctatacatgg cttgatcagc aaggactccc tgcccaaaga 1081 cagcaggcct tcctttattg gctcttcttc agggcacact tccactactc tctaagacct 1141 cctgcctaag tgcagccccg tggggttcct cccttctctt cacagtcaca ttccaagcct 1201 catgtccact ggttcttctt ggtctcagtg tcaatgcagc ccccattgtg gtcacaggaa 1261 gcagaggagg ccacgttctt actagtttcc cttgcatggt ttagaaagct tgccctggtg 1321 cctcacccct tgccataatt actatgtcat ttgctggagc tctgcccatc ctgcccctga 1381 gcccatggca ctctatgttc taagaagtga aaatctacac tccagtgaga cagctctgca 1441 tactcattag gatggctagt atcaaaagaa agaaaatcag gctggccaac gggatgaaac 1501 cctgtctcta ctaaaaatac aaaaaaaaaa aaaaaaatta gccgggcgtg gtggtgagtg 1561 cctgtaatca cagctacttg ggaggctgag atgggagaat cacttgaacc cgggaggcag 1621 aggttgcagt gagccgagat tgtgcccctg cactccagcc tgagcgacag tgagactctg 1681 tctcagtcca tgaagatgta gaggagaaac tggaactctc gagcgttgct gggggggatt 1741 gtaaaatggt (2) INFORMATION FOR SEQ ID NO:2559: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1801 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2559: 1 ggatccaagt aggattgagt gtcctgtagt tattatccac agggaacatt ctacaaagtt 61 ttgggagact gtaatgtcat gggaaatgca agaatatgtg tccagcatgg aagggaatca 121 gtatggaagt cttttgataa attgtggcat ttatcactaa cattgcctca aaactttaga 181 ctacctgcca tatacaaatt agaggtgaaa attacttcca tgtaatatac aagccaacac 241 aaagaatcct atcccagttt cttggatgga taggcaagaa tctgggtaag gtttattgtg 301 caataatcct cttctctctt ctataggcca ggatttaagt ttacctcaaa aatggaaaat 361 tttggctggg aaaattacat gtgggaagac atcttcagtg gagattttag taattacagt 421 ttcagctatg accctacccc ttttctacta gattctgccc catgttggcc agaatcccta 481 gaaatcaatt atgttttgat catcatctat gccctgatgt ttctactgaa cgtgatgtga 541 aactccctgc cgatgctggt catcttattc agctgagtca gccactgtca ccgatgtcta 601 cctgctgacc ctggccttgg ccgacctgtt cttttccctg acattgccca tcttggctgc 661 ctccaagatg aatggctgga tttttggcac aatctgtgcc aggtggtcta gctcctgaag 721 gaagtcaact tctacggtgg tattctacta ctggcctgcc gcagcatgga ctgttacctg 781 gccattgtcc atgccacacg cacactgacc cagcagcgcc acttggtcaa gttcatatgt 841 ctgggtttgt ggaacctgtt cctgttactg tccctacgca tcttgctttt ccgaaggacc 901 ttctacccat ccaatgttag cccagtctgc tatgaggaca tgggcaacaa tacagcaaac 961 tggtggatgc tgttacggat cctgccccag tcctttggct tcatcgtgcc gctgcgatca 1021 tgctgttctg ctacagattc accctgcata cgctgtttaa ggcccatatg gggcagaagc 1081 actggaccat gtgggtcat' tttgctgttg tcctcatttt cctgctctgc tggctgccct 1141 acaacctggt cctgctggca gacaccctca tgggaaccca gatgaccaat gagacctgtg 1201 agcgccgcaa cgacatcaac caggccctgg atgccactga gattctgggc atccttcaca 1261 gctacctcaa tcccctcatc tacgccttca ttggccagaa gttttgccat ggacttctca 1321 agattatagc catacacggc ttgatcagca aggactccct gcccaaagac agcaggcctt 1381 cctttgttgg ctcttcttca gggcacactt ccactactct ctaagacctc ttgcctaagt 1441 gcagtcccgt ggggttcctc ccttctcttc acagtcacat tccaagcctc atgtccacta 1501 gctcttcttg gtctcagtgt cagtgcagcc cccactgtgg tcgcaggaag cagaggaggc 1561 cacgttctta ctagtttccc ttgcatgatt tagaaagcct gccctggtac ctcacccctt 1621 gccataatta ctacatcact tgctggagct ctgtccctcc tgcccttgag ctcatggcac 1681 tctatgttct aagaagtgaa aatctacact ccagtgagac agctctgcat actcattagg 1741 atggttaatg tcagaagaaa gaaaatcata aaatagaagg tgtccacaaa ggtgcagatg 1801 ataagtg (2) INFORMATION FOR SEQ ID NO:2560: Ci) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1501 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2560: 1 gtcaggattt aagtttacct caaaaatgga agattttaac atggagagtg acagctttga 61 agatttctgg aaaggtgaag atcttagtaa ttacagttac agctctaccc tgcccccttt 121 tctactagat gccgccccat gtgaaccaga atccctggaa atcaacaagt attttgtggt 181 cattatctat gccctggtat tcctgctgag cctgctggga aactccctcg tgatgctggt 241 catcttatac agcagggtcg gccgctccgt cactgatgtc tacctgctga acctagcctt 301 ggccgaccta ctctttgccc tgaccttgcc catctgggcc gcctccaagg tgaatggctg 361 gatttttggc acattcctgt gcaaggtggt ctcactcctg aaggaagtca acttctatag 421 tggcatcctg ctactggcct gcatcagtgt ggaccgttac ctggccattg tccatgccac 481 acgcacactg acccagaagc gctacttggt caaattcaca tgtctcagca tctggggtct WO 00/09525 PCT/US99/17712 EPI-109 728 541 gtccttgctc ctggccctgc ctgtcttact tttccgaagg accgtctact catccaatgt 601 tagcccagcc tgctatgagg acatgggcaa caatacagca aactggcgga tgctgttacg 661 gatcctgccc cagtcctttg gcttcatcgt gccactgctg atcatgctgt tctgctacgg 721 attcaccctg cgtacgctgt ttaaggccca catggggcag aagcaccggg ccatgcgggt 781 catctttgct gtcgtcctca tcttcctgct ttgctggctg ccctacaacc tggtcctgct 841 ggcagacacc ctcatgagga cccaggtgat ccaggagacc tgtgagcgcc gcaatcacat 901 cgaccgggct ctggatgcca ccgagattct gggcatcctt cacagctgcc tcaaccccct 961 catctacgcc ttcattggcc agaagtttcg ccatggactc ctcaagattc tagctataca 1021 tggcttgatc agcaaggact ccctgcccaa agacagcagg ccttcctttg ttggctcttc 1081 ttcagggcac acttccacta ctctctaaga cctcctgcct aagtgcagcc cgtggggttc 1141 ctcccttctc ttcacagtca cattccaagc ctcatgtcca ctggttcttc ttggtctcag 1201 tgtcaatgca gcccccattg tggtcacagg aagcagagga ggccacattc ttactagttt 1261 cccttgcatg gtttagaaag cttgccctgg tgcctcaccc cttgccataa ttactatgtc 1321 atttgctgga gctctgccca tcctgcccct gagcccatgg cactctatgt tctaagaagt 1381 gaaaatctac actccagtga gacagctctg catactcatt aggatggcta gtatcaaaag 1441 aaagaaaatc aggctggcca acgggatgaa accctgtctc tactaaaaat acaaaaaaaa 1501 aaaaaaaaaa (2) INFORMATION FOR SEQ ID NO:2561: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 2221 base pairs (B) TYPE: nucleic acid (C) STRA1NDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2561: 1 gggagaaaca tagggaatag aaaataagta agaaggggac acctgggaac aggtttgcct 61 tcttgcattt tgcttaatgc tggcccttcc ctgaatgtct aagaccaacc tggtccccac 121 atccaaatgc acagacacag ctgaggatgg agaaggctaa agagggacag aggtagagac 181 ataggctgag aggaggcagt tgtaggttga gctagggcta aggtgttttc cccatattcc 241 atcttacccc acactcaggc caggccttag agttgtggaa ggtggagaac actgggaagc 301 caacctccga agaagaccag gttggagtca aaggaggaag gagagctctc attgccaaac 361 caacagggaa gccaaggata tcccagtaac tgctctcaca tcattgatga gaatgccttg 421 aatccgagct actaaatcac atttccttcc ttctaacctt ccagttagat caaaccattg 481 ctgaaactga agaggacatg tcaaatatta cagatccaca gatgtgggat tttgatgatc 541 taaatttcac tggcatgcca cctgcagatg aagattacag cccctgtatg ctagaaactg 601 agacactcaa caagtatgtt gtgatcatcg cctatgccct agtgttcctg ctgagcctgc 661 tgggaaactc cctggtgatg ctggtcatct tatacagcag ggtcggccgc tccgtcactg 721 atgtctacct gctgaacctg gccttggccg acctactctt tgccctgacc ttgcccatct 781 gggccgcctc caaggtgaat ggctggattt ttggcacatt cctgtgcaag gtggtctcac 841 tcctgaagga agtcaacttc tacagtggca tcctgctgtt ggcctgcatc agtgtggacc 901 gttacctggc cattgtccat gccacacgca cactgaccca gaagcgtcac ttggtcaagt 961 ttgtttgtct tggctgctgg ggactgtcta tgaatctgtc cctgcccttc ttccttttcc 1021 gccaggctta ccatccaaac aattccagtc cagtttgcta tgaggtcctg ggaaatgaca 1081 cagcaaaatg gcggatggtg ttgcggatcc tgcctcacac ctttggcttc atcgtgccgc 1141 tgtttgtcat gctgttctgc tatggattca ccctgcgtac actgtttaag gcccacatgg 1201 ggcagaagca ccgagccatg agggtcatct ttgctgtcgt cctcatcttc ctgctttgct 1261 ggctgcccta caacctggtc ctgctggcag acaccctcat gaggacccag gtgatccagg 1321 agagctgtga gcgccgcaac aacatcggcc gggccctgga tgccactgag attctgggat 1381 ttctccatag ctgcctcaac cccatcatct acgccttcat cggccaaaat tttcgccatg 1441 gattcctcaa gatcctggct atgcatggcc tggtcagcaa ggagttcttg gcacgtcatc 1501 gtgttacctc ctacacttct tcgtctgtca atgtctcttc caacctctga aaaccatcga 1561 tgaaggaata tctcttctca gaaggaaaga ataaccaaca ccctgaggtt gtgtgtggaa 1621 ggtgatctgg ctctggacag gcactatctg ggttttgggg ggacgctata ggatgtgggg 1681 aagttaggaa ctggtgtctt caggggccac accaaccttc tgaggagctg ttgaggtacc 1741 tccaaggacc ggcctttgca cctccatgga aacgaagcac catcattccc gttgaacgtc 1801 acatctttaa cccactaact ggctaattag catggccaca tctgagcccc gaatctgaca 1861 ttagatgaga gaacagggct gaagctgtgt cctcatgagg gctggatgct ctcgttgacc 1921 ctcacaggag catctcctca actctgagtg ttaagcgttg agccaccaag ctggtggctc 1981 tgtgtgctct gatccgagct caggggggtg gttttcccat ctcaggtgtg ttgcagtgtc 2041 tgctggagac attgaggcag gcactgccaa aacatcaacc tgccagctgg ccttgtgagg 2101 agctggaaac acatgttccc cttgggggtg gtggatgaac aaagagaaag agggtttgga 2161 agccagatct atgccacaag aacccccttt acccccatga ccaacatcgc agacacatgt 2221 gctggccacc tgctgagccc caagt (2) INFORMATION FOR SEQ ID NO:2562: (1) SEQUENCE CHARACTERISTICS: (A) LENGTH: 9245 base pairs (B) TYPE: nucleic acid (C) STPRANDEDNESS: single WO 00/09525 PCT/US99/17712 EPI-109 729 (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2562: 1 tattcatcaa gtgccctcta gctgttaagt cactctgatc tctgactgca gctcctactg 61 ttggacacac ctggccggtg cttcagttag atcaaaccat tgctgaaact gaagaggaca 121 tgtcaaatat tacagatcca cagatgtggg attttgatga tctaaatttc actggcatgc 181 cacctgcaga tgaagattac agcccctgta tgctagaaac tgagacactc aacaagtatg 241 ttgtgatcat cgcctatgcc ctagtgttcc tgctgagcct gctgggaaac tccctggtga 301 tgctggtcat cttatacagc agggtcggcc gctccgtcac tgatgtctac ctgctgaacc 361 tggccttggc cgacctactc tttgccctga ccttgcccat ctgggccgcc tccaaggtga 421 atggctggat ttttggcaca ttcctgtgca aggtggtctc actcctgaag gaagtcaact 481 tctacagtgg catcctgctg ttggcctgca tcagtgtgga ccgttacctg gccattgtcc 541 atgccacacg cacactgacc cagaagcgtc acttggtcaa gtttgtttgt cttggctgct 601 ggggactgtc tatgaatctg tccctgccct tcttcctttt ccgccaggct taccatccaa 661 acaattccag tccagtttgc tatgaggtcc tgggaaatga cacagcaaaa tggcggatgg 721 tgttgcggat cctgcctcac acctttggct tcatcgtgcc gctgtttgtc atgctgttct 781 gctatggatt caccctgcgt acactgttta aggcccacat ggggcagaag caccgagcca 841 tgagggtcat ctttgctgtc gtcctcatct tcctgctttg ctggctgccc tacaacctgg 901 tcctgctggc agacaccctc atgaggaccc aggtgatcca ggagagctgt gagcgccgca 961 acaacatcgg ccgggccctg gatgccactg agattctggg atttctccat agctgcctca 1021 accccatcat ctacgccttc atcggccaaa attttcgcca tggattcctc aagatcctgg 1081 ctatgcatgg cctggtcagc aaggagttct tggcacgtca tcgtgttacc tcctacactt 1141 cttcgtctgt caatgtctct tccaacctct gaaaaccatc gatgaaggaa tatctcttct 1201 cagaaggaaa gaataaccaa caccctgagg ttgtgtgtgg aaggtgatct ggctctggac 1261 aggcactatc tgggttttgg ggggacgcta taggatgtgg ggaagttagg aactggtgtc 1321 ttcaggggcc acaccaacct tctgaggagc tgttgaggta cctccaagga ccggcctttg 1381 cacctccatg gaaacgaagc accatcattc ccgttgaacg tcacatcttt aacccactaa 1441 ctggctaatt agcatggcca catctgagcc ccgaatctga cattagatga gagaacaggg 1501 ctgaagctgt gtcctcatga gggctggatg ctctcgttga ccctcacagg agcatctcct 1561 caactctgag tgttaagcgt tgagccacca agctggtggc tctgtgtgct ctgatccgag 1621 ctcagggggg tggttttccc atctcaggtg tgttgcagtg tctgctggag acattgaggc 1681 aggcactgcc aaaacatcaa cctgccagct ggccttgtga ggagctggaa acacatgttc 1741 cccttggggg tggtggatga acaaagagaa agagggtttg gaagccagat ctatgccaca 1801 agaaccccct ttacccccat gaccaacatc gcagacacat gtgctggcca cctgctgagc 1861 cccaagtgga acgagacaag cagcccttag cccttcccct ctgcagcttc caggctggcg 1921 tgcagcatca gcatccctag aaagccatgt gcagccacca gtccattggg caggcagatg 1981 ttcctaataa agcttctgtt ccgtgct 1 cctacaggtg aaaagcccag cgacccagtc aggatttaag tttacctcaa aaatggaaga 61 ttttaacatg gagagtgaca gctttgaaga tttctggaaa ggtgaagatc ttagtaatta 121 cagttacagc tctaccctgc ccccttttct actagatgcc gccccatgtg aaccagaatc 181 cctggaaatc aacaagtatt ttgtggtcat tatctatgcc ctggtattcc tgctgagcct 241 gctgggaaac tccctcgtga tgctggtcat cttatacagc agggtcggcc gctccgtcac 301 tgatgtctac ctgctgaacc tagccttggc cgacctactc tttgccctga ccttgcccat 361 ctgggccgcc tccaaggtga atggctggat ttttggcaca ttcctgtgca aggtggtctc 421 actcctgaag gaagtcaact tctatagtgg catcctgcta ctggcctgca tcagtgtgga 481 ccgttacctg gccattgtcc atgccacacg cacactgacc cagaagcgct acttggtcaa 541 attcatatgt ctcagcatct ggggtctgtc cttgctcctg gccctgcctg tcttactttt 601 ccgaaggacc gtctactcat ccaatgttag cccagcctgc tatgaggaca tgggcaacaa 661 tacagcaaac tggcggatgc tgttacggat cctgccccag tcctttggct tcatcgtgcc 721 actgctgatc atgctgttct gctacggatt caccctgcgt acgctgttta aggcccacat 781 ggggcagaag caccgggcca tgcgggtcat ctttgctgtc gtcctcatct tcctgctttg 841 ctggctgccc tacaacctgg tcctgctggc agacaccctc atgaggaccc aggtgatcca 901 ggagacctgt gagcgccgca atcacatcga ccgggctctg gatgccaccg agattctggg 961 catccttcac agctgcctca accccctcat ctacgccttc attggccaga agtttcgcca 1021 tggactcctc aagattctag ctatacatgg cttgatcagc aaggactccc tgcccaaaga 1081 cagcaggcct tcctttgttg gctcttcttc agggcacact tccactactc tctaagacct 1141 cctgcctaag tgcagccccg tggggttcct cccttctctt cacagtcaca ttccaagcct 1201 catgtccact ggttcttctt ggtctcagtg tcaatgcagc ccccattgtg gtcacaggaa 1261 gcagaggagg ccacgttctt actagtttcc cttgcatggt ttagaaagct tgccctggtg 1321 cctcacccct tgccataatt actatgtcat ttgctggagc tctgcccatc ctgcccctga 1381 gcccatggca ctctatgttc taagaagtga aaatctacac tccagtgaga cagctctgca 1441 tactcattag gatggctagt atcaaaagaa agaaaatcag gctggccaac gggatgaaac 1501 cctgtctcta ctaaaaatac aaaaaaaaaa aaaaaaatta gccgggcgtg gtggtgagtg 1561 cctgtaatca cagctacttg ggaggctgag atgggagaat cacttgaacc cgggaggcag 1621 aggttgcagt gagccgagat tgtgcccctg cactccagcc tgagcgacag tgagactctg 1681 tctcagtcca tgaagatgta gaggagaaac tggaactctc gagcgttgct gggggggatt 1741 gtaaaatggt 1 ggatccaagt aggattgagt gtcctgtagt tattatccac agggaacatt ctacaaagtt 61 ttgggagact gtaatgcat gggaaatgca agaatatgtg tccagcatgg aagggaatca WO 00/09525 PCT/US99/17712 EPI-109 730 121 gtatggaagt cttttgataa attgtggcat ttatcactaa cattgcctca aaactttaga 181 ctacctgcca tatacaaatt agaggtgaaa attacttcca tgtaatatac aagccaacac 241 aaagaatcct atcccagttt cttggatgga taggcaagaa tctgggtaag gtttattgtg 301 caataatcct cttctctczt ctataggcca ggatttaagt ttacctcaaa aatggaaaat 361 tttggctggg aaaattacat gtgggaagac atcttcagtg gagattttag taattacagt 421 ttcagctatg accctacccc ttttctacta gattctgccc catgttggcc agaatcccta 481 gaaatcaatt atgttttgat catcatctat gccctgatgt ttctactgaa cgtgatgtga 541 aactccctgc cgatgctagt catcttattc agctgagtca gccactgtca ccgatgtcta 601 cctgctgacc ctggccttgg ccgacctgtt cttttccctg acattgccca tcttggctgc 661 ctccaagatg aatggctgga tttttggcac aatctgtgcc aggtggtcta gctcctgaag 721 gaagtcaact tctacggtgg tattctacta ctggcctgcc gcagcatgga ctgttacctg 781 gccattgtcc atgccacacg cacactgacc cagcagcgcc acttggtcaa gttcatatgt 841 ctgggtttgt ggaacctatt cctgttactg tccctacgca tcttgctttt ccgaaggacc 901 ttctacccat ccaatgttag cccagtctgc tatgaggaca tgggcaacaa tacagcaaac 961 tggtggatgc tgttacggat cctgccccag tcctttggct tcatcgtgcc gctgcgatca 1021 tgctgttctg ctacagattc accctgcata cgctgtttaa ggcccatatg gggcagaagc 1081 actggaccat gtgggtcatc tttgctgttg tcctcatttt cctgctctgc tggctgccct 1141 acaacctggt cctgctggca gacaccctca tgggaaccca gatgaccaat gagacctgtg 1201 agcgccgcaa cgacatcaac caggccctgg atgccactga gattctgggc atccttcaca 1261 gctacctcaa tcccctcatc tacgccttca ttggccagaa gttttgccat ggacttctca 1321 agattatagc catacacggc ttgatcagca aggactccct gcccaaagac agcaggcctt 1381 cctttgttgg ctcttcttca gggcacactt ccactactct ctaagacctc ttgcctaagt 1441 gcagtcccgt ggggttcctc ccttctcttc acagtcacat tccaagcctc atgtccacta 1501 gctcttcttg gtctcagtgt cagtgcagcc cccactgtgg tcgcaggaag cagaggaggc 1561 cacgttctta ctagtttccc ttgcatgatt tagaaagcct gccctggtac ctcacccctt 1621 gccataatta ctacatcact tgctggagct ctgtccctcc tgcccttgag ctcatggcac 1681 tctatgttct aagaagtgaa aatctacact ccagtgagac agctctgcat actcattagg 1741 atggttaatg tcagaagaaa gaaaatcata aaatagaagg tgtccacaaa ggtgcagatg 1801 ataagtg 1 gtcaggattt aagtttacct caaaaatgga agattttaac atggagagtg acagctttga 61 agatttctgg aaaggtgaag atcttagtaa ttacagttac agctctaccc tgcccccttt 121 tctactagat gccgccccat gtgaaccaga atccctggaa atcaacaagt attttgtggt 181 cattatctat gccctggtat tcctgctgag cctgctggga aactccctcg tgatgctggt 241 catcttatac agcagggtcg gccgctccgt cactgatgtc tacctgctga acctagcctt 301 ggccgaccta ctctttgccc tgaccttgcc catctgggcc gcctccaagg tgaatggctg 361 gatttttggc acattcctgt gcaaggtggt ctcactcctg aaggaagtca acttctatag 421 tggcatcctg ctactggcct gcatcagtgt ggaccgttac ctggccattg tccatgccac 481 acgcacactg acccagaagc gctacttggt caaattcata tgtctcagca tctggggtct 541 gtccttgctc ctggccctgc ctgtcttact tttccgaagg accgtctact catccaatgt 601 tagcccagcc tgctatgagg acatgggcaa caatacagca aactggcgga tgctgttacg 661 gatcctgccc cagtcctttg gcttcatcgt gccactgctg atcatgctgt tctgctacgg 721 attcaccctg cgtacgctat ttaaggccca catggggcag aagcaccggg ccatgcgggt 781 catctttgct gtcgtcctca tcttcctgct ttgctggctg ccctacaacc tggtcctgct 841 ggcagacacc ctcatgagga cccaggtgat ccaggagacc tgtgagcgcc gcaatcacat 901 cgaccgggct ctggatgcca ccgagattct gggcatcctt cacagctgcc tcaaccccct 961 catctacgcc ttcattggcc agaagtttcg ccatggactc ctcaagattc tagctataca 1021 tggcttgatc agcaaggact ccctgcccaa agacagcagg ccttcctttg ttggctcttc 1081 ttcagggcac acttccacta ctctctaaga cctcctgcct aagtgcagcc cgtggggttc 1141 ctcccttctc ttcacagtca cattccaagc ctcatgtcca ctggttcttc ttggtctcag 1201 tgtcaatgca gcccccattg tggtcacagg aagcagagga ggccacgttc ttactagttt 1261 cccttgcatg gtttagaaag cttgccctgg tgcctcaccc cttgccataa ttactatgtc 1321 atttgctgga gctctgccca tcctgcccct gagcccatgg cactctatgt tctaagaagt 1381 gaaaatctac actccagtga gacagctctg catactcatt aggatggcta gtatcaaaag 1441 aaagaaaatc aggctggcca acgggatgaa accctgtctc tactaaaaat acaaaaaaaa 1501 aaaaaaaaaa 1 gggagaaaca tagggaatag aaaataagta agaaggggac acctgggaac aggtttgcct 61 tcttgcattt tgcttaatgc tggcccttcc ctgaatgtct aagaccaacc tggtccccac 121 atccaaatgc acagacacag ctgaggatgg agaaggctaa agagggacag aggtagagac 181 ataggctgag aggaggcagt tgtaggttga gctagggcta aggtgttttc cccatattcc 241 atcttacccc acactcaggc caggccttag agttgtggaa ggtggagaac actgggaagc 301 caacctccga agaagaccag gttggagtca aaggaggaag gagagctctc attgccaaac 361 caacagggaa gccaaggata tcccagtaac tgctctcaca tcattgatga gaatgccttg 421 aatccgagct actaaatcac atttccttcc ttctaacctt ccagttagat caaaccattg 481 ctgaaactga agaggacatg tcaaatatta cagatccaca gatgtgggat tttgatgatc 541 taaatttcac tggcatgcca cccgcagatg aagattacag cccctgtatg ctagaaactg 601 agacactcaa caagtatgtt gtgatcatcg cctatgccct agtgttcctg ctgagcctgc 661 tgggaaactc cctggtgatg ctggtcatct tatacagcag ggtcggccgc tccgtcactg 721 atgtctacct gctgaacctg gccttggccg acctactctt tgccctgacc ttgcccatct WO 00/09525 PCT/US99/17712 EPI-109 731 781 gggccgcctc caaggtgaat ggctggattt ttggcacatt cctgtgcaag gtggtctcac 841 tcctgaagga agtcaacttc tacagtggca tcctgctgtt ggcctgcatc agtgtggacc 901 gttacctggc cattgtccat gccacacgca cactgaccca gaagcgtcac ttggtcaagt 961 ttgtttgtct tggctgctgg ggactgtcta tgaatctgtc cctgcccttc ttccttttcc 1021 gccaggctta ccatccaaac aattccagtc cagtttgcta tgaggtcctg ggaaatgaca 1081 cagcaaaatg gcggatggtg ttgcggatcc tgcctcacac ctttggcttc atcgtgccgc 1141 tgtttgtcat gctgttctgc tatggattca ccctgcgtac actgtttaag gcccacatgg 1201 ggcagaagca ccgagccatg agggtcatct ttgctgtcgt cctcatcttc ctgctttgct 1261 ggctgcccta caacctggtc ctgctggcag acaccctcat gaggacccag gtgatccagg 1321 agagctgtga gcgccgcaac aacatcggcc gggccctgga tgccactgag attctgggat 1381 ttctccatag ctgcctcaac cccatcatct acgccttcat cggccaaaat tttcgccatg 1441 gattcctcaa gatcctggct atgcatggcc tggtcagcaa ggagttcttg gcacgtcatc 1501 gtgttacctc ctacacttct tcgtctgtca atgtctcttc caacctctga aaaccatcga 1561 tgaaggaata tctcttctca gaaggaaaga ataaccaaca ccctgaggtt gtgtgtggaa 1621 ggtgatctgg ctctggacag gcactatctg ggttttgggg ggacgctata ggatgtgggg 1681 aagttaggaa ctggtgtctt caggggccac accaaccttc tgaggagctg ttgaggtacc 1741 tccaaggacc ggcctttgca cctccatgga aacgaagcac catcattccc gttgaacgtc 1801 acatctttaa cccactaact ggctaattag catggccaca tctgagcccc gaatctgaca 1861 ttagatgaga gaacagggct gaagctgtgt cctcatgagg gctggatgct ctcgttgacc 1921 ctcacaggag catctcctca actctgagtg ttaagcgttg agccaccaag ctggtggctc 1981 tgtgtgctct gatccgagct caggggggtg gttttcccat ctcaggtgtg ttgcagtgtc 2041 tgctggagac attgaggcag gcactgccaa aacatcaacc tgccagctgg ccttgtgagg 2101 agctggaaac acatgttccc cttgggggtg gtggatgaac aaagagaaag agggtttgga 2161 agccagatct atgccacaag aacccccttt acccccatga ccaacatcgc agacacatgt 2221 gctggccacc tgctgagccc caagt (2) INFORMATION FOR SEQ ID NO:2563: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 541 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2563: 1 ccgctgtcaa gatgcttctg gccatggtcc ttacctctgc cctgctcctg tgctccgtgg 61 caggccaggg gtgtccaacc ttggcgggga tcctggacat caacttcctc atcaacaaga 121 tgcaggaaga tccagcttcc aagtgccact gcagtgctaa tgtgaccagt tgtctctgtt 181 tgggcattcc ctctgacaac tgcaccagac catgcttcag tgagagactg tctcagatga 241 ccaataccac catgcaaaca agatacccac tgattttcag tcgggtgaaa aaatcagttg 301 aagtactaaa gaacaacaag tgtccatatt tttcctgtga acagccatgc aaccaaacca 361 cggcaggcaa cgcgctgaca tttctgaaga gtcttctgga aattttccag aaagaaaaga 421 tgagagggat gagaggcaag atatgaagat gaaatattat ttatcctatt tattaaattt 481 aaaaagcttt ctctttaagt tgctacaatt taaaaatcaa gtaagctact ctaaatcagt 541 atcagttgtg attatttgtt taacattgta tgtctttatt ttgaaataaa t (2) INFORMATION FOR SEQ ID NO:2564: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 2761 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (0) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2564: 1 atatatatat gcataatagt ctctgtgtaa cagtaagtgg atgcagtaac tggtgtgagg 61 gcaacttgga gagtgtgctt ggaggcacag agatgctcag ggctgcctgg actgcctcca 121 tgatggtggc ctgctctgta ttaggtgagt gttcaggaaa ggtgagggca gggcagccca 181 cagcttcaca gtggcccagg gaagcagggc aggcaggcta tgaggcctag taggcatctg 241 ggccagactt tgacactgag gccatggaat gggtggggct ctgagaacag acccaagtga 301 tcatgggctg aaggctatgt ccacagatcc aaggcgggat aggctgtact gggcagtgat 361 gtcagccagg ctccccagcg ggactggggg tgtcaggggc agctctgtcc caggtggcag 421 acactggttt cccctcctgc tctcacaacc ggcctgttac caggtgttgt ctgagctgtg 481 gtgaggcttc cctggtgaca ttcaggagca gggagcctgc gagtaagggt gtatgcatct 541 gccctgactg cctggccctg tggtcaagga tgggggaagg cagctctgcc tgcagctcca 601 ccccatttat aaagcactgt ggtgccttct gctgggacat gtgctgagtg gtgcctcgca 661 ggcactgccc tcgggaagtt cacaggctta tgtggaagct ggtgggaatg ggccaagaag 721 agaggtgtca ggagccaggt attgggcagg tcccaggtct ctgagcctca gtttcttcat 781 ctgtaggagg gtggtgaccc tgccctgctc agcttaccag gtacagatgt aagttttcag 841 tgcagaggaa aagcagagaa cttcccctca gatggccata cccccttgtc gctgtaccca 901 actctccggt cctactttgt agctctcagg tgtcacatgt ggatcctgcc ctaccatccc 961 ccttgccctg tctagaaacg aggcctgctg agcttggaac catcccactc cctgctctca 1021 agccgtctgc tcctgggtta gcctgtggct gacctggcct gattctacat agatgtgggt WO 00/09525 PCT/US99/17712 EPI-109 732 1081 gtttctccac tgctggggca gcagttgtcc attctggggc ctgggtcagc tctcagctgt 1141 ggccgttgtg cctgtgcttc cccaggtcct ggtggtgact ccaaccctgc cctcacatat 1201 cccaagagca ggctgactgc cttccccatt cccacctttc cagtaactgc tgcaagaacg 1261 gacagacact gctgcagaga acttgccacg gtgtttcatg ctgtggctgg tggttccagg 1321 ctgcacgctc cattctagga aagggtgagg cttcctgatc atcagtctta acaggggact 1381 gtcctatggg tacctgtata cgctgccggg agtggggcag agtggggtta gagtagtgcc 1441 tgctgcccat tggggttgtg cgggttcctt aagggctgta gtctgtgtgc gtgtctggtt 1501 ttttcctcct ccttatcagt aatcagtctt gtataaccag gctggccctg cttcctgcct 1561 aggggctatc ggtgtaccat ctggagttgc aaatggggtg atagggcgtc agcggccttc 1621 ccacacccaa gcacttcctg acacccagcc cctcatctct agccaacctc tggctcccct 1681 agggatcctg gggctcaggc ctcacgctcc agcatccggg ggctttgccc ttctggtgtt 1741 gctcttcttt gcaggtgcct tggaacaggg gtgcaacaga gttcagaaag tgccatctgt 1801 tgcatggata ccctgctgcc accctcgtcc acctttctgg ggcagaacag ttggatgggt 1861 ctttatttaa gaggacaaaa gggagagaga atgcatagag gctgggtctg gtggctcacg 1921 cctgtaatcc caacactttg ggaggccaag gcaggtggat cccttgaggt caggaggtca 1981 agactagcct ggccaacatg gtgaaacccc gtctctacta aaaatacaaa aaaaaaaaaa 2041 ttagctgggc atggcgggag atgcctgtaa tcccagctac tcgggaggct gaggcaggat 2101 aatcacttga acccaggagg cggaggttgc agtgagccaa gatcacacca ctgcactcta 2161 gcctgggtga cagagggaga ctgtctcaaa aaaaaaaatt tgcttagaat ttgtctgtgt 2221 gaccctgggc aagtcatttc ccctccttgg gactcagttc cttgcctgtg aacggggaca 2281 gtgcttctcc cttacagagc tgttgtgaga attaaagtag aaaatgtacc tatggtggtt 2341 gttggtagtg accagttccc ccaaccctga ctcccctgca ggatggggcc tgggcccggg 2401 aatgggggat gggctggcag aggatgactg tcccagagag gagtcttctc ggcagatgtg 2461 gagacctagc tgagtcagag gccaggatct aagtttgagg gtgttcctta caccctgcag 2521 ccatgagtct ttggctgagt caaatggcct ttctgagctc agttccttat cagtaaagcc 2581 tggacagtgg tccaggacgc tggacactgt gtgagtgtta ggacacagga cactgtgtga 2641 gtgcaggtgg ggacccatgg agcactctgc tggggagcaa ttcatgggga gcacccctcc 2701 agagagggat gatttgcaca gggccctcag cccagtccct tgcaggctgg accttggaga 2761 gtgaggccct gaggcgagac atgggcacct ggctcctggc ctgcatctgc (2) INFORMATION FOR SEQ ID NO:2565: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 17041 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2565: 1 ggatccatgc ccagaattat tcacgaaatt cacttaaaat agcaatatg cttgaaccca 61 ggagtctgag gctgcagcga gctatgatca tgtcactgca ctccagccca gcctgggcga 121 cagagcaaga ctctgtgtct aaagaaatga aaataaaaat aaataaaata gcatatacag 181 gcaacaatcc aaatgttcat tgcagaaatt atgattatta ttgtttttct tttagaggca 241 gggtgtcact ctgttgccca gactaatctt gacctcctgt gatcctcaag agatcctccg 301 gtctctgctt cccaaagttc ttggattaca ggtgtgaggc actgggccta gacattgcag 361 ggattattaa accatggtgc atactaccat taaaggtatg aggtaggtt tatatgctga 421 cctagaaaga tggtgcaaca ccatagggga acaagaaggc tgcaaagtgg cagcacagca 481 ggagtcttta agaaataggt atttgtttca gcttaagaag tgtctggctg ggcgtggtgg 541 ctcacacctg taatcccagc acttagggag gcttaggtgg gcggatcact tgaggttagg 601 agttcaagac cagcccagtc aacaccggtg aaaccccatc tctactaaaa atacaaagaa 661 attagctggg cttggtggca ggtggctgta atcccagcta ctcaggagct gaggcaggag 721 aatcatctga acccgggagg ccgaggttgc agtgagccta gatcgcacca ctgcactcca 781 gcctgggtga cagagtaaga ctcggtcaaa aaaaaaaaaa aaaaagaccg ggtgcgaggt 841 ctctcgcctg taatcccagc actttgggag gcctaggcag gaggatcaca aggtcaggag 901 atcgagacca tcctggccaa catggtgaaa ccccatctct actaaaatac aaaaattagc 961 cgggtgtgat ggcacacgcc tgtagtccca gctactcagg aggctgaggc aggggaatcg 1021 cttgaaacca ggaggtggag gctgcagtga gccgagatca cgccactgca ctccagcctg 1081 gcgacagagc aagactccat ctcaaaaaag aaaagaaaac aaacaaacaa acaaaatccc 1141 caaaaagcaa aagtgtctgc atggacttgt gcctaactac tcacagtggc tacttcttgg 1201 gggaggtgaa aggggaccct gttaaagaat ttttcttctg tattgttttt cttcaactga 1261 gtctgcatta attttatatt taatactctc cccacccctg atgctcacag gttgctttag 1321 ctggtggaag gagaacctgc acctctggtt ttggcaaagt gtagaagggg acaagggcac 1381 tgctctgcac ctgcacaggt tcttgcctcc tggggtcagt ttaatgaatc tcagtggtgt 1441 ttcttgggaa gaacacagtg gacactcact tgccagtcag tagacaaatc actgaagtcc 1501 atgtctggca gttctcaatg tcatggggac tgtaaggttg tcatgtctca cagttccctg 1561 acttagaaga ttagtggtga cagacacttc tcagctctgc tcgggagagc agctctgtaa 1621 tgcgcttgtg gtttcagatg tgggcggcct gtgtgaacct gtcgtgcaaa gctcacgtca 1681 ccaactgctg cagttatctc ctgaatcagg ctgagggtct ttgctgtgca cccagagata 1741 gttgggtgac aaatcacctc caggttgggg atgcctcaga cttgtgacgg gactgggcag 1801 atgcatctgg gaaggtgagt ctgtgctttg ggcttcccaa cctctcaagt cagcatgaaa 1861 ttcagaaggc agagagggac atgtggccct ccaactcggg gcccagggag ccactgtggc WO 00/09525 PCT/US99/17712 EPI-109 733 1921 atttgagagc gccacc:aa ctttacctcc tctggtgtcc tggccttgtg tatctcttag 1981 agatggcaaa atttgcagcc ctgacctcaa ggattacaaa ctaatttcca gccctgtagg 2041 ggtcatgggt tctgctgtgg ccagtgtggc actgagtttg tcaggcagaa tttctaatta 2101 tggaaggaac tctgcttcct cagtgattga actgaccttt gtgggggtgc ctttgtgggg 2161 tgagaatggg catacttg; cctcagttgt gatggccatg gggtggagct gaggtctagg 2221 cccagggctg ggaaagcrtc taccaacccc gaggcatttg ggtgttttag ggcagaagag 2281 gagccaggag gatgggtatg ccccactgga gctgtgtgtg gggcagcagg tgagggtggg 2341 attccagagg gagggtcaac ccagccaagc agaggaaggg gaggagaggg tttgttttgg 2401 aaagaacatc accctctcag tttcctgggg tctgqatagc ctgttcttgt gatgagctgg 2461 aggatgtggg ccctgcttqg atcctcctct cccctccctg cccccatttt ctcttcctgt 2521 gatttatgct gttctgggct caccctcttc ccagagctct cacgctacag ctgacaggca 2581 gggcaggcgt tttaattatt attaattttt ttttgagaca gagtttgaga cagtatcaag 2641 agtgggtatc ctctcagcgt gtcttcaagt agcatcccag agccccgctc ctgggtaccc 2701 acaacatgaa caccgtccag aagcaagggc agcctctgca ggtggggcgg gggttggaaa 2761 acatttatca aacggttgag ttgggtgcag gggatgcaac atgatcaaac agggtcttgc 2821 ctccaggagc ctcatgtagg gacaacgcac agtgatgacc ttcaactgca gtggggcagc 2881 aaggctgtgg gaggggtgtt ttgggcagag caggcgacgt gggtacctct tcaccaagac 2941 agcaggaaga gcacggacat cattttcccg tctcacctcc agactcccag gggactgtgc 3001 caatatcctc actggagccc tgcccatggc cactgctcaa cccttgggcc ctgtcagttc 3061 agggctgtgc agaaggagag ttgcctgtgc tcaggctcag gggttccgtc cagctaagga 3121 ggcctactag gggactgggg aaaggcctca tgaaggacca ggcctgtgat ggggagggaa 3181 gatggcagag gggacagtgg gaagcagagc agcaggggtc tcctccacgc ctctctgtac 3241 ttctcccacc cacccttgcc tgctcccctc tgccctgggt atgtgccctt gtccacccaa 3301 cacctctgca gtgccaagtc cagccctgac ttcttcctga gctgtggccc agcgttccca 3361 caggcattta cctcacggat gcagcactgc ccctcatcct cttctctgaa agtgtgtggg 3421 aaatgcttct tggtgccarc tctctcccac cctgccttcc ctgcaccttc tctatgaggt 3481 gtctgttgtc tctgtacttg cctccagctg gcctttcaga ccccatccct ccctgcctcc 3541 tgcccatccc tacccctgtc agcaccttac atactctgtg cccaacagca ttggggattc 3601 ccactgtgct gaaggaagtc ctcatgtggt ccagagaggg agctggcccc tgctcccatt 3661 tccagcacca ttttctggca caggctccat gtccccaggc tccagctgct tctggggtac 3721 caaggtctgc atttcttcct cttcccccag cagacagaag accttgctgg acaggtgtcc 3781 acttcaatag taacttctga ggctgccagc ctcctgaatg gtccagaaga accagaccct 3841 tccccgcccc cattaaaaaa gacaaaatat ggccaggcat gttggctcat gcctgacatc 3901 ccagcacttt gggaggccaa agcaggtgaa tcacttgagg ccaggagtac gagaccagcc 3961 tgacaaacat ggtgaaaccc tgtgtctact aaaaatacaa aaattagcca ggcgtggtga 4021 ctcatgcttg taaatgcttg taatcccagc tacttgggag gctgaagcag gaggatcact 4081 tgaactcggg aggcagaggt tgcagtgagc cgagatcacg ccactgtgtt ccagcctgag 4141 cgacagagcg acactccgtc taaaaaaaaa aaatatatat atatatacac acatatatat 4201 atgcataata gtctctgtgt aacagtaagt ggatgcagta actggtgtga gggcaacttg 4261 gagagtgtgc ttggaggcac agagatgctc agggctgcct ggactgcctc catgatggtg 4321 gcctgctctg tattaggtga gtgttcagga aaggtgaggg cagggcagcc cacagcttca 4381 cagtggccca gggaagcagg gcaggcaggc tatgaggcct agtaggcatc tgggccagac 4441 tttgacactg aggccatgga atgggtgggg ctctgagaac agaccaaagt gatcatgggc 4501 tgaaggctat gtccacagat ccaaggcggg ataggctgtg ctgggcagtg atgtcagcca 4561 ggctccccag cgggactggg ggtgtcaggg gcagctctgt cccaggtggc agacactggt 4621 ttcccctcct gctctcacaa ccggcctgtt accaggtgtt gtctgagctg tggtgaggct 4681 tccctggtga cattcaggag cagggagcct gtgagtaagg gtgtatgcat ctgccctgac 4741 tgcctggccc tgtggtcaag gatgggggaa ggcagctctg cctgcagctc caccccattt 4801 ataaagcact gtggtgcctt ctgctggggc atgtgctgag tggtgcctcg caggcactgc 4861 cctcgggaag ttcacaggct tatgtggaag ctggtgggaa tgggccaaga agagaggtgt 4921 caggagccag gtattgggca ggtcccaggt ctctgagcct cagtttcttc atctgtagga 4981 gggtggtgac cctgccctgc tcagcttacc aggtacagat gtaagttttc agtgcagagg 5041 aaaagcagag aagttcccct cagatggcca tacccccttg tcgctgtacc caactctccg 5101 gtcctacttt gtagctctca ggtgtcacat gtggatcctg ccctaccatc ccccttccct 5161 gtctagaaac gaggcctgct gagcttggag ccatcccact ccctgctctc aagccgtctg 5221 ctcctgggtt agcctgtggc tggcctggcc tgattctaca tagatgtggg tgtttctcca 5281 ctgctggggc agcagttgtc cattctgggg cctgggtcag ctctcagctg tggccgttgt 5341 gcctgtgctt ccccaggtcc tggtggtgac tccaaccctg ccctcacata tcccaagagc 5401 aggctgactg ccttccccat tcccaccttt ccagtaactg ctgcaagaac ggacagacac 5461 tgctgcagag aacttgccac ggtgtttcat gctgtggctg gtggttccag gctgcacgct 5521 ccattctagg aaagggtgag gcttcctgat catcagtctt aacaggggac tgtcctatgg 5581 gtacctgtat acgctgccgg gagtggggca gagtggggtt agagtagtgc ctgctgccca 5641 ttggggttgt gcgggttcct taagggctgt agtctgtgtg cgtgtctggt tttttcctcc 5701 tccttatcag taatcagcc: tgtataacca ggctggccct gcttcctgcc taggggctat 5761 cggtgtacca tctggagttg caaatggggt gatagggcgt cagcggcctt cccacaccca 5821 agcacttcct gacacccagc ccctcatctc tagccaacct ctggctcccc tagggatcct 5881 ggggctcagg cctcacgctc cagcatccgg gggctttgcc ttctggtgtt gctcttcttt 5941 gcaggtgcct tggaacaggg gtgcaacaga gttcagaaag gccatctgt tgcatggata WO 00/09525 PCT/US99/17712 EPI-109 734 6001 ccctgctgcc accctcgtcc acctttctgg ggcagaacag ttggatgggt ctttatttaa 6061 gaggacaaaa gggagagaga atgcatagag gctgggtctg gtgtcacgcc tgtaatccca 6121 acactttggg aggccaaggc aggtggatcc cttgaggtca ggaggtcaag actagcctgg 6181 ccaacatggt gaaaccccgt ctctactaaa aatacaaaaa aaaaaaaatt agctgggcat 6241 ggcgggagat gcctgtaatc ccagctactc gggaggctga ggcaggataa tcacttgaac 6301 ccaggaggcg gaggttgcag tgagccaaga tcacaccact gcactctagc ctgggtgaca 6361 gagggagact gtctcaaaaa aaaaaatttg cttagaattt gtctgtgtga ccctgggcaa 6421 gtcatttccc ctccttggga ctcagttcct tgcctgtgaa cggggacagt gcttctccct 6481 tacagagctg ttgtgagaat taaagtagaa aatgtaccta tggtggttgt tggtagtgac 6541 cagttccccc aaccctgact cccctgcagg atggggcctg ggcccgggaa tgggggatgg 6601 gctggcagag gatgactgtc ccagagagga gtcttctcgg cagatgtgga gacctagctg 6661 agtcagaggc caggatctaa gtttgagggt gttccttaca ccctgcagcc atgagtcttt 6721 ggctgagtca aatggccttt ctgagctcag ttccttatca gtaaagcctg gacagtggtc 6781 caggacgctg gacactgtgt gagtgttagg acacaggaca ctgtgtgagt gcaggtgggg 6841 acccatggag cactctgctg gggagcaatt catggggagc acccctccag agagggatga 6901 tttgcacagg gccctcagcc cagtcccttg caggctggac cttggagagt gaggccctga 6961 ggcgagacat gggcacctgg ctcctggcct gcatctgcat ctgcacctgt gtctgcttgg 7021 gagtctctgt cacaggggaa ggacaaggtg agggctgggc actaatgtct gtatgaggtg 7081 ggtggagaac tagggcatgt ttgggggact gggttgtccg atgtcaagcc tctagggaaa 7141 ggtttggccc aaactgtgct ggggcatgtc ctctaggggt cagcctggac ctcagtctct 7201 agtctcccta cttttacctc cctaccttca ttccctggac cgactgtagt ctcccttcct 7261 tcactctctt gacgcctctc cagatctgac ttgcccgtgt accacaggtc agagcccatc 7321 acttcccagg cctcccagtg cttccctgga cagattctgg gatcatttac tggtgactgc 7381 cctgctaggg tgtcagctgt cagatcctcc ccaacccccg agctcagctc tggcctgaag 7441 tacttaccgt gggctcctga tggtcactgt ctccagggcc aaggtctaga accttcacct 7501 gcctcaccaa caacattctc aggatcgatt gccactggtc tgccccagag ctgggacagg 7561 gctccagccc ctggctcctc ttcaccaggt gagcatggag ggccatgccc acctggacag 7621 ggatgagggt gagttcccca ggattgaagc agctatgcca ggacagtgta gcagccccgt 7681 ggtgctgaca aatgcccttt ccagcaacca ggctcctggc ggcacacata agtgcatctt 7741 gcggggcagt gagtgcaccg tcgtgctgcc acctgaggca gtgctcgtgc catctgacaa 7801 tttcaccatc actttccacc actgcatgtc tgggagggag caggtcagcc tggtggaccc 7861 ggagtacctg ccccggagac acggtgagca gcagctatag gtctggggcg gggccgcttg 7921 gcaagaacat cctggctgct tgggggtttg gagcagggcc ttgcagcctg tgagtggccc 7981 agtgagtgtt ctcagtccca gccgagtgag atccagggct gggggcaggc ttggcccttg 8041 ggaggggagg gcccatatgg ttactgcagg ggcagggttt tggcaggaaa taaacatgca 8101 cggctgctag ttggggcagg ggctggcact tgagtcatgt gaaatgcact tcagtcatac 8161 caggaaggac tccaataaga tgctgggaaa agcttccagc agcagactgt gaaggaaagg 8221 gaaagcaaga tttagaaacc acctagtcta ggtgcagagg ccagaggaag tcattgctgt 8281 cctgtcccgc ctggggcttt tgtggaccag tctcccagtg aggtgcctgg tctgagaggg 8341 ccttgaccat tccccttggg agtctttcag accccagtct tgtgtgttct gactgacaca 8401 cccagaccca tggggcttca gcctcacatg gattcactct gttccagtta agctggaccc 8461 gccctctgac ttgcagagca acatcagttc tggccactgc atcctgacct ggagcatcag 8521 tcctgccttg gagccaatga ccacacttct cagctatgag ctggccttca agaagcagga 8581 agaggcctgg gaggtaacac tttggctggc tttccctggg ggcctctctc ctgggaacag 8641 cagtccaggg tagactcccc actctacata gggagatgtc aacttgtagt gatgagaagg 8701 gaggaactag agcggggtgt gtgtgcacac acacatgctg gcatgcagat gtgtatgctt 8761 tatgtgtgtg tatgggagta gggtgagtgc gcctgtgtct ctgtgtgtgc acataagtgt 8821 ggtgagtgtg catgtatgtg tttatgtgta cacatatgta actgtgcaca ctcatgtttg 8881 tgtgcccatg tttgtgtgtt tatatgtaag tgtacatatg tgtgtgcctg tgccttgcat 8941 ttgtgtgagt gtgcacatgg gcatgcctat gtgtatgagt gtgtatgtga gtgtggtgag 9001 ttgcttctgt gcacacactt ttgtttatga gtgtgcatgc aagtgtgatg agtgtgaaag 9061 tgttcctgta gacatgtttg cctgtgtgtg catatgtgta tttgtgggca aacgcagctg 9121 tgtctgtgag tgtgagtgtg ccttctgtgt gtgtgtgtgc acgtgaatgt ggtgagtgtg 9181 tctgtgtgtt aacacaagtg tgttcaagag tgtgttatat gagcatataa tgcatgtgtg 9241 tattctcgag ggctgaggga cccagcccca ccttcaccac ctgctaactg tccccacccc 9301 cacagcaggc ccagcacagg gatcacattg tcggggtgac ctggcttata cttgaagcct 9361 ttgagctgga ccctggcttt atccatgagg ccaggctgcg tgtccagatg gccacactgg 9421 aggatgatgt ggtagaggag gagcgttata caggccagtg gagtgagtgg agccagcctg 9481 tgtgcttcca ggctccccag agacaaggtg ggcactgctg tggctgctgc acttccagcg 9541 gagtctgggc tgggcgtctt ctcccctgtt cacctcagcc ctgcaccctt tcaccctcct 9601 gtaagcccct ccccgaggca gccatgcctc agttgacccc cttcctctga aggtctgagg 9661 tctgtaggga ggacagaaac acctgccaac tctggggctt cctgggaacc tgtagttagt 9721 ggctgctgtt aggagtgagg gtggcagggc tgcacaccag ggctgggctc ctgcctggag 9781 gctggacatg acctcagtgt ccttaatggg ggctggactg acccttgcgc actgcagtgc 9841 tgagatggcc cagggacttt atgacccacc ttgtggcaga tgggaagagt gaggcccagg 9901 agtgtggttc acacaaggtc cttcagcagg tgacacaaac ctccaaggcc catcacaagg 9961 tccttcagca ggtgacacaa aggtggaagg cccatcacaa accttccact ttggcccagg 10021 gcactaaagg gcgcaccttt gccaggtggg tttgggggga gcctcctggc actgaggctg WO 00/09525 PCT/US99/17712 EPI-109 735 10081 ctcacagccc tgggcccttc ctgtccacag gccctctgat cccaccczgg gggtggccag 10141 gcaacaccct tgttgctgtg tccatctttc tcctgctgac tggcccaacc tacctcctgt 10201 tcaagctgtc gcccaggtag gtggctgatg tgtgcgtgtg tgtacatgtg tgagcgggca 10261 agagtgtgca tgttagtgta tgtgtgcaga tgtgtgactg tgtgcatgtg tgagtgtgtg 10321 gtgggtgggc catcaagggc cgcccttgtc tggttcctcc cctcccczct ccactgcctg 10381 gtcctggacg gggtgggctt ttcgagtctc caccctggtc cagaagaggg ttctcaagtt 10441 gccaggggag agcagggaag gggggtctga ggcagaggct gaagataagg gcagcttggt 10501 cccgaccaga cccagagtca ccgagatcaa gagccggagg tcctagtctc ctgcctctgg 10561 aggagcttgg tttgttcatt tgttcacatg ttctacgaaa ggacagttgg ggcatctgqt 10621 gtgctcagga ccctgttctc agaacaagat ggacaagggc cctccttaaa taaaccgtca 10681 cgcctcatgc accacatgtc aggttacaag acagggtgca ggggccatgt caggccgcag 10741 atgtgaggaa gagggtgtgg ggagaggggt gttgggtggg gctaagtggg agggtgcttc 10801 gcttctcctt ggagcaaagg aaagtgtaaa actgtgtgac acaacctagt ttatgttttg 10861 aggaatagat tgctgggaca aggggacatg ggggacctgc tggaggccaa tgggggccag 10921 tgaggtgccc acagggagac gatttgcatg agccagtgaa agaagtggag atagagaaaa 10981 gtggagagaa ttgcagggtc tcatgagggg aaatagaagg gacatgtggg tggatgagat 11041 atgagtggtg acccctgagg tggggaaatg ggggacagcc ttgcagggag gttggtgaag 11101 tctatttgga cctgttgggt tggagcccca ggtgacatcc ttgtgggagg gtcagtggat 11161 ccttggcagc aagtctggtg ctcagggaga cactgggtgg ggtgggagcc acagaccttc 11221 tgctgatggc aaagacaggg ttcctggagg tgctggctcc ctctgtgatc tgaggaccca 11281 gctagtaact ccccgttctg aacccgccat cgcagctcac gctqtaaagg acgcgcgcct 11341 cagtataaat cagttctatg cggccgttag gcaaggaggc ccagttgggt cctgccctga 11401 gagtgggttg gaatgtgatg agatgggaga gaggcagtgg cagggacgag gtgggcggac 11461 ctcctgctga tggaaggaag ctcagcctct gcagtgacct caggccacct gggtcgccat 11521 aggcctctga ctggcctctc ttggcctcag ggtgaagaga atcttctacc agaacgtgcc 11581 ctctccagcg atgttcttcc agcccctcta cagtgtacac aatgggaact tccaggtgtg 11641 tgcagagacc acagaaggac atggggggca ggggttgccc agagctctgg cctgcccaag 11701 atgttggctt tcatgagggt tggcggccag tatgggaggc ttgtcagtgc ttggagcctt 11761 ttttgtatat tcagtgaatt tcaatttata cgcgtatctc aaatggggaa aaattagctt 11821 tattttccat tgctgatttc tttttgttct caggtctcta gttccattgt tgattgaaaa 11881 aatgtaaatt tctcataact tatctctgtc ccctctggtt tgcagctttc tgcacccacc 11941 atgtgcctca cctcctcctt ctgcgaaggt gtctgtcctg tggccatggg gaagggtctg 12001 tggtgtgtgt gctgcccttg gggctctcac tgcctctggg ctcctgctct gcctggtccc 12061 ctggtctccc cggatcacat gatggcacca cagctgagga gtgggctctg cacttccccc 12121 ccttccaccc atgttgggct cctacagccc aggcaccagt gagcaacttg ggggttgcat 12181 cagcccctcc cctccctgct gggctgttgg ttcatgcccc ctgggtggga ggagggggag 12241 agggagagct ccagtgagtg gtctctggtt tttcccctca gactcctcac tttgggcaaa 12301 ggacaagagg cagtgagggc ccctccctgg ggtctgggcc aagctgacca ctcttctcca 12361 gaatcttccc tccctgtccc cttcacactg tggctccagc ttactatgca gaaaaatcct 12421 tttctctctc aatgaggagc gtagttttca agatttttgt ccaaaaatat aatttgaacc 12481 atgaaccggg catctggctc ttggcagagt ctccctcttt ccccaaggtg gtagatgtga 12541 ctgtcaggag cctgggcagc tgacgacaag gctgagcagg tcagattgtg actgtcccct 12601 ggactgtcat cctgttgcgg gcaccagctg ttccctagag aactaggaca cctgccacgg 12661 gttatttaga ctgcgggtga ggatctggtg ccataggttg gtctccaggg agcactgcag 12721 tgatggaggg tgttgtgtgt gtgatgcatg ggatggaggc tcctggtccc accaagggaa 12781 cagcttcctt ttggaggcgg gggcctcctg tggccccaca gaaggatcca ggtctgctgg 12841 ccatagccga gtgctttgaa agtcaccagt cctgacagcg attcgtgtgt gtgtctgtgt 12901 gtgtgtgtgt gtgtttatgt gtctgtgtgt gttcgtgtgt gtgtctgtgt gtgtgtttgt 12961 gtgtgtatgt ctgtgtgtgt gtgtttatgt gtgtgtgtct gtatgtgttt aagtctgtgt 13021 gtgtttgtgt gtgtgtgtct ctgtgtgtgt gtctgtatct gtgtgtgttt gtgtctgtgt 13081 gtgtttgtgt gtgtgtctgt gtgtgtctgt gtgtgtgtct gtgtgtgtgt ttatgtgtct 13141 gtgtatgttt gtgtgtgtgt ttgtgtgtgt gtgtttgtgt ttatgtgtgt atgtctgtgt 13201 gtgtctgtgt gtctgtgtgt gtatgtgtct gtgtgtgttt atgtgtctgt gtgtgttcgt 13261 gtgtgtgtct gtgtgtgtgt gtttgtgtgt gtatgtctgt gtgtgtgtgt gtttatgtgt 13321 gtgtgtctgt gtgtgtttat gtctgtgtgt gtttgtgtgt gtgtgtctcg tgtgtgtgtg 13381 tctgtgtgta tctgtgtgtg tttgtgtgtg tgtgtgtctc tgtgtgtgtg tgtgtttgtg 13441 tatgtttgtg tgtgtgtgtg tgtgtgttgg gaatgcccag tctctgcagc tgctgaaagg 13501 ccctgaggca catgctgtca ggagctggct ctgtcctggg cagatatcac catctgtacc 13561 tcggttcagg ctgccgtggg caccaggccc tgtgctgggg gagtgctgag gagcctgaag 13621 ggactcaggg tcccgtgatg aggctgggct ggcacatgga ggaaagacag aatgtccaag 13681 acacaggcgc tgcttggcct ctgggtgtgg acctcaggag ggcttcctgg aggaggaggg 13741 atgctgggct tgccagaaag gaggcagctg ctcccaggat gagttctgaa catgctacct 13801 gagcccttcc ctcctcccgt gctctgttcc agacttggat gggggcccac ggggccggtg 13861 tgctgttgag ccaggactgt gctggcaccc cacagggagc cttggagccc tgcgtccagg 13921 aggccactgc actgctcact tgtggcccag cgcgtccttg gaaatctgtg gccctggagg 13981 aggaacaqga gggccctggg accaggctcc cggggaacct gagctcagag gatgtgctgc 14041 cagcagggtg tacggagtgg agggtacaga cgcttgccta tctgccacag gaggactggg 14101 cccccacgtc cctgactagg ccggctcccc cagactcaga gggcagcagg agcagcagca WO 00/09525 PCT/US99/17712 EPI-109 736 14161 gcagcagcag cagcaacaac aacaactact gtgccttggg ctgctatggg ggatggcacc 14221 tctcagccct cccaggaaac acacagagct ctgggcccat cccagccctg gcctgtggcc 14281 tttcttgtga ccatcagggc ctggagaccc agcaaggagt tgcctgggtg ctggctggtc 14341 actgccagag gcctgggctg catgaggacc tccagggcat gttgctccct tctgtcctca 14401 gcaaggctcg gtcctggaca ttctaggtcc ctgactcgcc agatgcatca tgtccatttt 14461 gggaaaatgg actgaagttt ctggagccct tgtctgagac tgaacctcct gagaaggggc 14521 ccctagcagc ggtcagaggt cctgtctgga tggaggctgg aggctccccc ctcaacccct 14581 ctgctcagtg cctgtgggga gcagcctcta ccctcagcat cctggccaca agttcttcct 14641 tccattgtcc cttttcttta tccctgacct ctctgagaag tggggtgtgg tctctcagct 14701 gttctgccct cataccctta aagggccagc ctgggcccag tggacacagg taaggcacca 14761 tgaccacctg gtgtgacctc tctgtgcctt actgaggcac ctttctagag attaaaaggg 14821 gcttgatggc tgttcccaaa gtgttgatgg ccgggagaag gggccagagg aggagtgagg 14881 ggtggggttt gtccagccct gggctttccg ggctctagag atagcatggt gtaggctcaa 14941 tgacagttct ggggacagca agttggaggt tcaggggcag cttcaggaca gcaggatgga 15001 ggctcaggga caattcctgg gaggccagtg ccctcgttcc tccttgtcct catcctcccc 15061 cttgctccag gaaactgaga gctgagcctg gagcttccag acagtcagtg ctgggggtga 15121 ccatccagca gtgatggtgg cctgtgaagg gtcctgcttc tgtcctcagc ctctcatggg 15181 gtgggcttgt ggaggagctg tggtctggag agagtggcag ttggagcaga acgtgcctgc 15241 gtttgtttcc tagggctgtc gtaacaaagt gccacaaaat ggttagctta gaaccacaga 15301 gatttgttgt ctcacaattc tgaagtccag aagttggaaa taaagatgtt ggcagtgttc 15361 ccaaccacat gttcttgggc tcccatgaaa cagaagttga tattaggcca aggaagcttc 15421 ccagacaaga ctttattaag tcttatgccc cgaaagtttg ggcagaagag agacggtgca 15481 ggaggaagaa ttcttggctg actccccaag gggaatgcat tgtggtgtct taaggagggt 15541 gacatacata atttatgagc tacatgagtg tcattgcaca tatggggtgg agcgaagggt 15601 gctcagacgc atgctaacac atacgttgca tgatcagaaa atggcagata agcccctccc 15661 tgggtgagga ctttagtatt atcataagac cagggtcatt ctcctggcct tgtgcacaag 15721 caggtgatgg agtcaactcc cgtcagtaag acttatggcg ggatgctgct tatcttagtt 15781 tatttcagac agttggcaag gtctggccag cgagtatggc acctggaggg tggtgctgca 15841 aggtctagtg gtcagcgggc acgtatggaa caatacgtta gtgggggtgg gccgagtccc 15901 atttatactc tctcagcagg gccatgctcc ctctgaaggc actagggaag gattagtttc 15961 aggcctctct tcagcttctg ttagtttctt ggcttgtgac accaaagctg taatctttct 16021 tttgttttgt ttttgtgacg gagttttgct cttgttgccc aggctggagt gcaatggcac 16081 aatctcggct cactgcaacc tcctcctccc aggtttaagc aattcttctg cctcagcctt 16141 tggagtagct gtgattacaa ggcacctgct accacgcctg gctagttttt gtatttttag 16201 tagagacggt gtttcgctat gttggccagg ctggtctcaa actcctgata tcaagtgatc 16261 cgtctgtctc tgcctcccaa agtgttggga ttacaggcat gagccaccgt gcctggccaa 16321 agttccagtc tttacaggga tttttccttg tgtgcatttc tgtgtccaaa tttccccttt 16381 ttaaaatcac aataatagtg aattaaggct ggccctaacg atttaatctt aacttgatca 16441 tctgcaaaga cactatttcc atataaggtc acattcacag ctactggggt taggacttca 16501 acctagaggg cctgacttct ggcccaacac atcatggccc atcccagcat gccccatccc 16561 cttcctgggt gccccaggca gatcacagga gggcctgact gctgggcttt gggctgacat 16621 tgggatcatc tgcctagtta gggctgtgac cagactgaga taggaggtgg gacctgactc 16681 ctgaggcagg gcttgaactc tggaccagat tacagactag ctgaaacagg caaaagcacc 16741 cctccataag acacacccac tggtgccaag tgagtttgcc gttctcatgg taacagctgg 16801 aaattactgc ccctttccat ggcaatgacc tgaaagttac cacccctttt ctagaaattt 16861 ctaaataacc tcctccttaa tttgtatata gttacaagtg ggtataaata tgtgtgcaga 16921 actgcctctg agctgctact ctgggctgac tgcctatggg gcatccctgc tccataagga 16981 gcagtacctc tgctgccact gtgcacagct gcttaaataa aagttgctct ctaataccac 17041 cgactcgccc ttgaattctt tcctgggtga agc (2) INFORMATION FOR SEQ ID NO:2566: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19802 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2566: 1 atatatatat gcataatagt ctctgtgtaa cagtaagtgg atgcagtaac tggtgtgagg 61 gcaacttgga gagtgtgctt ggaggcacag agatgctcag ggctgcctgg actgcctcca 121 tgatggtggc ctgctctgta ttaggtgagt gttcaggaaa ggtgagggca gggcagccca 181 cagcttcaca gtggcccagg gaagcagggc aggcaggcta tgaggcctag taggcatctg 241 ggccagactt tgacactgag gccatggaat gggtggggct ctgagaacag acccaagtga 301 tcatgggctg aaggctatgt ccacagatcc aaggcgggat aggctgtact gggcagtgat 361 gtcagccagg ctccccagcg ggactggggg tgtcaggggc agctctgtcc caggtggcag 421 acactggttt cccctcctgc tctcacaacc ggcctgttac caggtgttgt ctgagctgtg 481 gtgaggcttc cctggtgaca ttcaggagca gggagcctgc gagtaagggt gtatgcatct 541 gccctgactg ccggccctg tggtcaagga tgggggaagg cagctctgcc tgcagctcca 601 ccccatttat aaagcactgt ggtgccttct gctgggacat gtgctgagtg gtgcctcgca 661 ggcactgccc tcgggaagtt cacaggctta tgtggaagct ggtgggaatg ggccaagaag WO 00/09525 PCTIUS99/17712 EPI-109 737 721 agaggtgtca ggagccaggz attgggcagg tcccaggtct ctgagcctca gtttcttcat 781 ctgtaggagg gtggtgaccc tgccctgctc agcttaccag gtacagatgt aagttttcag 841 tgcagaggaa aagcagaaaa cttcccctca gatggccata cccccttgtc gctgtaccca 901 actctccggt cctactttgt agctctcagg tgtcacatgt ggatcctgcc ctaccatccc 961 ccttgccctg tctagaaacg aggcctgctg agcttggaac catcccactc cctgctctca 1021 agccgtctgc tcctgggtta gcctgtggct gacctggcct gattctacat agatgtgggt 1081 gtttctccac tgctggggca gcagttgtcc attctggggc ctgggtcagc tctcagctgt 1141 ggccgttgtg cctgtgcttc cccaggtcct ggtggtgact ccaaccctgc cctcacatat 1201 cccaagagca ggctgactgc cttccccatt cccacctttc cagtaactgc rgcaagaacg 1261 gacagacact gctgcagaga acttgccacg gtgtttcatg ctgtggctgg tggttccagg 1321 ctgcacgctc cattctagga aagggtgagg cttcctgatc atcagtctta acaggggact 1381 gtcctatggg tacctgtata cgctgccggg agtggggcag agtggggtta gagtagtgcc 1441 tgctgcccat tggggttgcg cgggttcctt aagggctgta gtctgtgtgc gtgtctggtt 1501 ttttcctcct ccttatcagt aatcagtctt gtataaccag gctggccctg cttcctgcct 1561 aggggctatc ggtgtaccat ctggagttgc aaatggggtg atagggcgtc agcggccttc 1621 ccacacccaa gcacttcctg acacccagcc cctcatctct agccaacctc tggctcccct 1681 agggatcctg gggctcaggc ctcacgctcc agcatccggg ggctttgccc ttctggtgtt 1741 gctcttcttt gcaggtgcct tggaacaggg gtgcaacaga gttcagaaag tgccatctgt 1801 tgcatggata ccctgctgcc accctcgtcc acctttctgg ggcagaacag ttggatgggt 1861 ctttatttaa gaggacaaaa gggagagaga atgcatagag gctgggtctg gtggctcacg 1921 cctgtaatcc caacactttg ggaggccaag gcaggtggat cccttgaggt caggaggtca 1981 agactagcct ggccaacatg gtgaaacccc gtctctacta aaaatacaaa aaaaaaaaaa 2041 ttagctgggc atggcgggag atgcctgtaa tcccagctac tcgggaggct gaggcaggat 2101 aatcacttga acccaggagg cggaggttgc agtgagccaa gatcacacca ctgcactcta 2161 gcctgggtga cagagggaga ctgtctcaaa aaaaaaaatt tgcttagaat ttgtctgtgt 2221 gaccctgggc aagtcatttc ccctccttgg gactcagttc cttgcctgtg aacggggaca 2281 gtgcttctcc cttacagagc tgttgtgaga attaaagtag aaaatgtacc tatggtggtt 2341 gttggtagtg accagttccc ccaaccctga ctcccctgca ggatggggcc tgggcccggg 2401 aatgggggat gggctggcag aggatgactg tcccagagag gagtcttctc ggcagatgtg 2461 gagacctagc tgagtcagag gccaggatct aagtttgagg gtgttcctta caccctgcag 2521 ccatgagtct ttggctgagt caaatggcct ttctgagctc agttccttat cagtaaagcc 2581 tggacagtgg tccaggacgc tggacactgt gtgagtgtta ggacacagga cactgtgtga 2641 gtgcaggtgg ggacccatgg agcactctgc tggggagcaa ttcatgggga gcacccctcc 2701 agagagggat gatttgcaca gggccctcag cccagtccct tgcaggctgg accttggaga 2761 gtgaggccct gaggcgagac atgggcacct ggctcctggc ctgcatctgc 1 ggatccatgc ccagaattat tcacgaaatt cacttaaaat agcatatatg cttgaaccca 61 ggagtctgag gctgcagcga gctatgatca tgtcactgca ctccagccca gcctgggcga 121 cagagcaaga ctctgtgtct aaagaaatga aaataaaaat aaataaaata gcatatacag 181 gcaacaatcc aaatgttcat tgcagaaatt atgattatta ttgtttttct tttagaggca 241 gggtgtcact ctgttgccca gactaatctt gacctcctgt gatcctcaag agatcctccg 301 gtctctgctt cccaaagttc ttggattaca ggtgtgaggc actgggccta gacattgcag 361 ggattattaa accatggtgc atactaccat taaaggtatg aggtaggttt tatatgctga 421 cctagaaaga tggtgcaaca ccatagggga acaagaaggc tgcaaagtgg cagcacagca 481 ggagtcttta agaaataggt atttgtttca gcttaagaag tgtctggctg ggcgtggtgg 541 ctcacacctg taatcccagc acttagggag gcttaggtgg gcggatcact tgaggttagg 601 agttcaagac cagcccagtc aacaccggtg aaaccccatc tctactaaaa atacaaagaa 661 attagctggg cttggtggca ggtggctgta atcccagcta ctcaggagct gaggcaggag 721 aatcatctga acccgggagg ccgaggttgc agtgagccta gatcgcacca ctgcactcca 781 gcctgggtga cagagtaaga ctcggtcaaa aaaaaaaaaa aaaaagaccg ggtgcgaggt 841 ctctcgcctg taatcccagc actttgggag gcctaggcag gaggatcaca aggtcaggag 901 atcgagacca tcctggccaa catggtgaaa ccccatctct actaaaatac aaaaattagc 961 cgggtgtgat ggcacacgcc tgtagtccca gctactcagg aggctgaggc aggggaatcg 1021 cttgaaacca ggaggtggag gctgcagtga gccgagatca cgccactgca ctccagcctg 1081 gcgacagagc aagactccat ctcaaaaaag aaaagaaaac aaacaaacaa acaaaatccc 1141 caaaaagcaa aagtgtctgc atggacttgt gcctaactac tcacagtggc tacttcttgg 1201 gggaggtgaa aggggaccct gttaaagaat ttttcttctg tattgttttt cttcaactga 1261 gtctgcatta attttatatt taatactctc cccacccctg atgctcacag gttgctttag 1321 ctggtggaag gagaacctgc acctctggtt ttgqcaaagt gtagaagggg acaagggcac 1381 tgctctgcac ctgcacaggt tcttgcctcc tggggtcagt ttaatgaatc tcagtggtgt 1441 ttcttgggaa gaacacagtg gacactcact tgccagtcag tagacaaatc actgaagtcc 1501 atgtctggca gttctcaatg tcatggggac tgtaaggttg tcatgtctca cagttccctg 1561 acttagaaga ttagtggtga cagacacttc tcagctctgc tcgggagagc agctctgtaa 1621 tgcgcttgtg gtttcagatg tgggcggcct gtgtgaacct gtcgtgcaaa gctcacgtca 1681 ccaactgctg cagttatctc ctgaatcagg ctgagggtct ttgctgtgca cccagagata 1741 gttgggtgac aaatcacctc caggttgggg atgcctcaga cttgtgatgg gactgggcag 1801 atgcatctgg gaaggtgagt ctgtgctttg ggcttcccaa cctctcaagt cagcatgaaa 1861 ttcagaaggc agagagggac atgtggccct ccaactcggg gcccagggag ccactgtggc 1921 atttgagagc gccaccctag ctttacctcc tctggtgtcc tggccttgtg tatctcttag WO 00/09525 PCT/US99/17712 EPI-109 738 1981 agatggeaaa atttgcagcc ctgacctcaa ggattacaaa ctaattcca gtcctgtagg 2041 ggtcatgggt tctgctgtgg ccagtgtggc actgagtttg tcaggcagaa tttctaatta 2101 tggaaggaac tctgcttcct cagtgattga actgaccttt gtgggggtgc ctttgtgggg 2161 tgagaatggg catacttggg cctcagttgt gatggccatg gggtggagct gaggtctagg 2221 cccagggctg ggaaagcttc taccaacccc gaggcatttg ggtgttttag ggcagaagag 2281 gagccaggag gatgggtatg ccccactgga gctgtgtgtg gggcagcagg tgagggtggg 2341 attccagagg gagggtcaac ccagccaagc agaggaaggg gaggagaggg tttgttttgg 2401 aaagaacatc accctctcag tttcctgggg tctggatagc ctgttcttgt gatgagctgg 2461 aggatgtggg ccctgcttgg atcctcctct cccctccctg cccccatttt ctcttcctgt 2521 gatttatgct gttctgggct caccctcttc ccagagctct cacgctacag ctgacaggca 2581 gggcaggcgt tttaattatt attaattttt ttttgagaca gagtttgaga cagtatcaag 2641 agtgggtatc ctctcagcgt gtcttcaagt agcatcccag agccccgctc ctgggtaccc 2701 acaacatgaa caccgtccag aagcaagggc agcctctgca ggtggggcgg gggttggaaa 2761 acatttatca aacggttgag ttgggtgcag gggatgcaac atgatcaaac agggtcttgc 2821 ctccaggagc ctcatgtagg gacaacgcac agtgatgacc ttcaactgca gtggggcagc 2881 aaggctgtgg gaggggtgtt ttgggcagag caggcgacgt gggtacctct tcaccaagac 2941 agcaggaaga gcacggacat cattttcccg tctcacctcc agactcccag gggactgtgc 3001 caatatcctc actggagccc tgcccatggc cactgctcaa cccttgggcc ctgtcagttc 3061 agggctgtgc agaaggagag ttgcctgtgc tcaggctcag gggttccgtc cagctaagga 3121 ggcctactag gggactgggg aaaggcctca tgaaggacca ggcctgtgat ggggagggaa 3181 gatggcagag gggacagtgg gaagcagagc agcaggggtc tcctccacgc ctctctgtac 3241 ttctcccacc cacccttgcc tgctcccctc tgccctgggt atgtgccctt gtccacccaa 3301 cacctctgca gtgccaagtc cagccctgac ttcttcctga gctgtggccc agcgttccca 3361 caggcattta cctcacggat gcagcactgc ccctcatcct cttctctgaa agtgtgtggg 3421 aaatgcttct tggtgccatc tctctcccac cctgccttcc ctgcaccttc tctatgaggt 3481 gtctgttgtc tctgtacttg cctccagctg gcctttcaga ccccatccct ccctgcctcc 3541 tgcccatccc tacccctgtc agcaccttac atactctgtg cccaacagca ttggggattc 3601 ccactgtgct gaaggaagtc ctcatgtggt ccagagaggg agctggcccc tgctcccatt 3661 tccagcacca ttttctggca caggctccat gtccccaggc tccagctgct tctggggtac 3721 caaggtctgc atttcttcct cttcccccag cagacagaag accttgctgg acaggtgtcc 3781 acttcaatag taacttctga ggctgccagc ctcctgaatg gtccagaaga accagaccct 3841 tccccgcccc cattaaaaaa gacaaaatat ggccaggcat gttggctcat gcctgacatc 3901 ccagcacttt gggaggccaa agcaggtgaa tcacttgagg ccaggagtac gagaccagc 3961 tgacaaacat ggtgaaaccc tgtgtctact aaaaatacaa aaattagcca ggcgtggtga 4021 ctcatgcttg taaatgcttg taatcccagc tacttgggag gctgaagcag gaggatcact 4081 tgaactcggg aggcagaggt tgcagtgagc cgagatcacg ccactgtgtt ccagcctgag 4141 cgacagagcg acactccgtc taaaaaaaaa aaatatatat atatatacac acatatatat 4201 atgcataata gtctctgtgt aacagtaagt ggatgcagta actggtgtga gggcaacttg 4261 gagagtgtgc ttggaggcac agagatgctc agggctgcct ggactgcctc catgatggtg 4321 gcctgctctg tattaggtga gtgttcagga aaggtgaggg cagggcagcc cacagcttca 4381 cagtggccca gggaagcagg gcaggcaggc tatgaggcct agtaggcatc tgggccagac 4441 tttgacactg aggccatgga atgggtgggg ctctgagaac agaccaaagt gatcatgggc 4501 tgaaggctat gtccacagat ccaaggcggg ataggctgtg ctgggcagtg atgtcagcca 4561 ggctccccag cgggactggg ggtgtcaggg gcagctctgt cccaggtggc agacactggt 4621 ttcccctcct gctctcacaa ccggcctgtt accaggtgtt gtctgagctg tggtgaggct 4681 tccctggtga cattcaggag cagggagcct gtgagtaagg gtgtatgcat ctgccctgac 4741 tgcctggccc tgtggtcaag gatgggggaa ggcagctctg cctgcagctc caccccattt 4801 ataaagcact gtggtgcctt ctgctggggc atgtgctgag tggtgcctcg caggcactgc 4861 cctcgggaag ttcacaggct tatgtggaag ctggtgggaa tgggccaaga agagaggtgt 4921 caggagccag gtattgggca ggtcccaggt ctctgagcct cagtttcttc atctgtagga 4981 gggtggtgac cctgccctgc tcagcttacc aggtacagat gtaagttttc agtgcagagg 5041 aaaagcagag aagttcccct cagatggcca tacccccttg tcgctgtacc caactctccg 5101 gtcctacttt gtagctctca ggtgtcacat gtggatcctg ccctaccatc ccccttccct 5161 gtctagaaac gaggcctgct gagcttggag ccatcccact ccctgctctc aagccgtctg 5221 ctcctgggtt agcctgtggc tggcctggcc tgattctaca tagatgtggg tgtttctcca 5281 ctgctggggc agcagttgtc cattctgggg cctgggtcag ctctcagctg tggccgttgt 5341 gcctgtgctt ccccaggtcc tggtggtgac tccaaccctg ccctcacata tcccaagagc 5401 aggctgactg ccttccccat tcccaccttt ccagtaactg ctgcaagaac ggacagacac 5461 tgctgcagag aacttgccac ggtgtttcat gctgtggctg gtggttccag gctgcacgct 5521 ccattctagg aaagggtgag gcttcctgat catcagtctt aacaggggac tgtcctatgg 5581 gtacctgtat acgctgccgg gagtggggca gagtggggtt agagtagtgc ctgctgccca 5641 ttggggttgt gcgggttcct taagggctgt agtctgtgtg cgtgtctggt tttttcctcc 5701 tccttatcag taatcagtct tgtataacca ggctggccct gcttcctgcc taggggctat 5761 cggtgtacca tctggagttg caaatggggt gatagggcgt cagcggcctt cccacaccca 5821 agcacttcct gacacccagc ccctcatctc tagccaacct ctggctcccc tagggatcct 5881 ggggctcagg cctcacgctc cagcatccgg gggctttgcc ttctggtgt gctcttcttt 5941 gcaggtgcct tggaacaggg gtgcaacaga gttcagaaag tgccatctgt tgcatggata 6001 ccctgctgcc accctcgtcc acctttctgg ggcagaacag ttggatgggt ctttatttaa WO 00/09525 PCT/US99/17712 EPI-109 739 6061 gaggacaaaa gggagagaga atgcatagag gctgggtctg gtgtcacacc tgtaatccca 6121 acactttggg aggccaaggc aggtggatcc cttgaggtca ggaggtcaag actagcctgg 6181 ccaacatggt gaaaccccgt ctctactaaa aatacaaaaa aaaaaaaatt agctgggcat 6241 ggcgggagat gcctgtaatc ccagctactc gggaggctga ggcaggataa tcacttgaac 6301 ccaggaggcg gaggttgcag tgagccaaga tcacaccact gcactctagc ctgggtgaca 6361 gagggagact gtctcaaaaa aaaaaatttg cttagaattt gtctgtgtga ccctgggcaa 6421 gtcatttccc ctccttggga ctcagttcct tgcctgtgaa cggggacagt gcttctccct 6481 tacagagctg ttgtgagaat taaagtagaa aatgtaccta tggtggttgt tggtagtgac 6541 cagttccccc aaccctgact cccctgcagg atggggcctg ggccaggaa tgggggatgg 6601 gctggcagag gatgactgtc ccagagagga gtcttctcgg caqatgtgga gacctagctg 6661 agtcagaggc caggatctaa gtttgagggt gttccttaca ccctgcagcc atgagtcttt 6721 ggctgagtca aatggccttt ctgagctcag ttccttatca gtaaagcctg gacagtggtc 6781 caggacgctg gacactgtgt gagtgttagg acacaggaca ctgtgtgagt gcaggtgggg 6841 acccatggag cactctgctg gggagcaatt catggggagc acccctccag agagggatga 6901 tttgcacagg gccctcagcc cagtcccttg caggctggac cttggagagt gaggccctga 6961 ggcgagacat gggcacctgg ctcctggcct gcatctgcat ctgcacctgt gtctgcttgg 7021 gagtctctgt cacaggggaa ggacaaggtg agggctgggc actaatgtct gtatgaggtg 7081 ggtggagaac tagggcatgt ttgggggact gggttgtccg atgtcaagcc tctagggaaa 7141 ggtttggccc aaactgtgct ggggcatgtc ctctaggggt cagcctggac ctcagtctct 7201 agtctcccta cttttacctc cctaccttca ttccctggac cgactgtagt ctcccttcct 7261 tcactctctt gacgcctctc cagatctgac ttgcccgtgt accacaggtc agagcccatc 7321 acttcccagg cctcccagtg cttccctgga cagattctgg gatcatttac tggtgactgc 7381 cctgctaggg tgtcagctgt cagatcctcc ccaacccccg agctcagctc tggcctgaag 7441 tacttaccgt gggctcctga tggtcactgt ctccagggcc aaggtctaga accttcacct 7501 gcctcaccaa caacattctc aggatcgatt gccactggtc tgccccagag ctgggacagg 7561 gctccagccc ctggctcctc ttcaccaggt gagcatggag ggccatgccc acctggacag 7621 ggatgagggt gagttcccca ggattgaagc agctatgcca ggacagtgta gcagccccgt 7681 ggtgctgaca aatgcccttt ccagcaacca ggctcctggc ggcacacata agtgcatctt 7741 gcggggcagt gagtgcaccg tcgtgctgcc acctgaggca gtgctcgtgc catctgacaa 7801 tttcaccatc actttccacc actgcatgtc tgggagggag caggtcagcc tggtggaccc 7861 ggagtacctg ccccggagac acggtgagca gcagctatag gtctggggcg gggccgcttg 7921 gcaagaacat cctggctgct tgggggtttg gagcagggcc ttgcagcctg tgagtggccc 7981 agtgagtgtt ctcagtccca gccgagtgag atccagggct gggggcaggc ttggcccttg 8041 ggaggggagg gcccatatgg ttactgcagg ggcagggttt tggcaggaaa taaacatgca 8101 cggctgctag ttggggcagg ggctggcact tgagtcatgt gaaatgcact tcagtcatac 8161 caggaaggac tccaataaga tgctgggaaa agcttccagc agcagactgt gaaggaaagg 8221 gaaagcaaga tttagaaacc acctagtcta ggtgcagagg ccagaggaag tcattgctgt 8281 cctgtcccgc ctggggcttt tgtggaccag tctcccagtg aggtgcctgg tctgagaggg 8341 ccttgaccat tccccttggg agtctttcag accccagtct tgtgtgttct gactgacaca 8401 cccagaccca tggggcttca gcctcacatg gattcactct gttccagtta agctggaccc 8461 gccctctgac ttgcagagca acatcagttc tggccactgc atcctgacct ggagcatcag 8521 tcctgccttg gagccaatga ccacacttct cagctatgag ctggccttca agaagcagga 8581 agaggcctgg gaggtaacac tttggctggc tttccctggg ggcctczctc ctgggaacag 8641 cagtccaggg tagactcccc actctacata gggagatgtc aacttgtagt gatgagaagg 8701 gaggaactag agcggggtgt gtgtgcacac acacatgctg gcatgcagat gtgtatgctt 8761 tatgtgtgtg tatgggagta gggtgagtgc gcctgtgtct ctgtgtgtgc acataagtgt 8821 ggtgagtgtg catgtatgtg tttatgtgta cacatatgta actgtgcaca ctcatgtttg 8881 tgtgcccatg tttgtgtgtt tatatgtaag tgtacatatg tgtgtgcctg tgccttgcat 8941 ttgtgtgagt gtgcacatgg gcatgcctat gtgtatgagt gtgtatgtga gtgtggtgag 9001 ttgcttctgt gcacacactt ttgtttatga gtgtgcatgc aagtgtgatg agtgtgaaag 9061 tgttcctgta gacatgtttg cctgtgtgtg catatgtgta tttgtgggca aacgcagctg 9121 tgtctgtgag tgtgagtgtg ccttctgtgt gtgtgtgtgc acgtgaatgt ggtgagtgtg 9181 tctgtgtgtt aacacaagtg tgttcaagag tgtgttatat gagcatataa tgcatgtgtg 9241 tattctcgag ggctgaggga cccagcccca ccttcaccac ctgctaactg tccccacccc 9301 cacagcaggc ccagcacagg gatcacattg tcggggtgac ctggcttata cttgaagcct 9361 ttgagctgga ccctggcttt atccatgagg ccaggctgcg tgtccagatg gccacactgg 9421 aggatgatgt ggtagaggag gagcgttata caggccagtg gagtgagtgg agccagcctg 9481 tgtgcttcca ggctccccag agacaaggtg ggcactgctg tggctgctgc acttccagcg 9541 gagtctgggc tgggcgtctt ctcccctgtt cacctcagcc ctgcaccctt tcaccctcct 9601 gtaagcccct ccccgaggca gccatgcctc agttgacccc cttcctctga aggtctgagg 9661 tctgtaggga ggacagaaac acctgccaac tctggggctt cctgggaacc tgtagttagt 9721 ggctgctgtt aggagtgagg gtggcagggc tgcacaccag ggctgggctc ctgcctggag 9781 gctggacatg acctcagtgt ccttaatggg ggctggactg acccttgcgc actgcagtgc 9841 tgagatggcc cagggacttt atgacccacc ttgtggcaga tgggaagagt gaggcccagg 9901 agtgtggttc acacaaggtc cttcagcagg tgacacaaac ctccaaggcc catcacaagg 9961 tccttcagca ggtgacacaa aggtggaagg cccatcacaa accttccact ttggcccagg 10021 gcactaaagg gcgcaccttt gccaggtggg tttgggggga gcctcctggc actgaggctg 10081 ctcacagccc tgggcccttc ctgtccacag gccctctgat cccaccctgg gggtggccag WO 00/09525 PCT/US99/17712 EPI-109 740 10141 gcaacaccct tgttgctgtg tccatctttc tcctgctgac tggcccgacc tacctcctgt 10201 tcaagctgtc gcccaggtag gtggctgatg tgtgcgtgtg tgtacatgtg tgagcgggca 10261 agagtgtgca tgttagtgta tgtgtgcaga tgtgtgactg tgtgcatgtg tgagtgtgtg 10321 gtgggtgggc catcaagggc cgcccttgtc tggttcctcc cctcccctct ccactgcctg 10381 gtcctggacg gggtgggctt ttcgagtctc caccctggtc cagaagaggg ttctcaagtt 10441 gccaggggag agcagggaag gggggtctga ggcagaggct gaagataagg gcagcttggt 10501 cccgaccaga cccagagtca ccgagatcaa gagccggagg tcctagtctc ctgcctctgg 10561 aggagcttgg tttgttcatt tgttcacatg ttctacgaaa ggacagttgg ggcatctggt 10621 gtgctcagga ccctgttctc agaacaagat ggacaagggc cctccttaaa taaaccgtca 10681 cgcctcatgc accacatgtc aggttacaag acagggtgca ggggccatgt caggccgcag 10741 atgtgaggaa gagggtgtgg ggagaggggt gttgggtggg gctaagtggg agggtgcttc 10801 gcttctcctt ggagcaaagg aaagtgtaaa actgtgtgac acaacctagt ttatgttttg 10861 aggaatagat tgctgggaca aggggacatg ggggacctgc tggaggccaa cgggggccag 10921 tgaggtgccc acagggagac gatttgcatg agccagtgaa agaagtggag atagagaaaa 10981 gtggagagaa ttgcagggtc tcatgagggg aaatagaagg gacatgtggg tggatgagat 11041 atgagtggtg acccctgagg tggggaaatg ggggacagcc ttgcagggag gttggtgaag 11101 tctatttgga cctgttgggt tggagcccca ggtgacatcc ttgtgggagg gtcagtggat 11161 ccttggcagc aagtctggtg ctcagggaga cactgggtgg ggtgggagcc acagaccttc 11221 tgctgatggc aaagacaggg ttcctggagg tgctggctcc ctctgtgatc tgaggaccca 11281 gctagtaact ccccgttctg aacccgccat cgcagctcac gctgtaaagg acgcgcgcct 11341 cagtataaat cagttctatg cggccgttag gcaaggaggc ccagttgggt cctgccctga 11401 gagtgggttg gaatgtgatg agatgggaga gaggcagtgg cagggacgag gtgggcggac 11461 ctcctgctga tggaaggaag ctcagcctct gcagtgacct caggccacct gggtcgccat 11521 aggcctctga ctggcctctc ttggcctcag ggtgaagaga atcttctacc agaacgtgcc 11581 ctctccagcg atgttcttcc agcccctcta cagtgtacac aatgggaact tccaggtgtg 11641 tgcagagacc acagaaggac atggggggca ggggttgccc agagctctgg cctgcccaag 11701 atgttggctt tcatgagggt tggcggccag tatgggaggc ttgtcagtgc ttggagcctt 11761 ttttgtatat tcagtgaatt tcaatttata cgcgtatctc aaatggggaa aaattagctt 11821 tattttccat tgctgatttc tttttgttct caggtctcta gttccattgt tgattgaaaa 11881 aatgtaaatt tctcataact tatctctgtc ccctctggtt tgcagctttc tgcacccacc 11941 atgtgcctca cctcctcctt ctgcgaaggt gtctgtcctg tggccatggg gaagggtctg 12001 tggtgtgtgt gctgcccttg gggctctcac tgcctctggg ctcctgctct gcctggtccc 12061 ctggtctccc cggatcacat gatggcacca cagctgagga gtgggctctg cacttccccc 12121 ccttccaccc atgttgggct cctacagccc aggcaccagt gagcaacttg ggggttgcat 12181 cagcccctcc cctccctgct gggctgttgg ttcatgcccc ctgggtggga ggagggggag 12241 agggagagct ccagtgagtg gtctctggtt tttcccctca gactcctcac tttgggcaaa 12301 ggacaagagg cagtgagggc ccctccctgg ggtctgggcc aagctgacca ctcttctcca 12361 gaatcttccc tccctgtccc cttcacactg tggctccagc ttactatgca gaaaaatcct 12421 tttctctctc aatgaggagc gtagttttca agatttttgt ccaaaaatat aatttgaacc 12481 atgaaccggg catctggctc ttggcagagt ctccctcttt ccccaaggtg gtagatgtga 12541 ctgtcaggag cctgggcagc tgacgacaag gctgagcagg tcagattgtg actgtcccct 12601 ggactgtcat cctgttgcgg gcaccagctg ttccctagag aactaggaca cctgccacgg 12661 gttatttaga ctgcgggtga ggatctggtg ccataggttg gtctccaggg agcactgcag 12721 tgatggaggg tgttgtgtgt gtgatgcatg ggatggaggc tcctggtccc accaagggaa 12781 cagcttcctt ttggaggcgg gggcctcctg tggccccaca gaaggatcca ggtctgctgg 12841 ccatagccga gtgctttgaa agtcaccagt cctgacagcg attcgtgtgt gtgtctgtgt 12901 gtgtgtgtgt gtgtttatgt gtctgtgtgt gttcgtgtgt gtgtctgtgt gtgtgtttgt 12961 gtgtgtatgt ctgtgtgtgt gtgtttatgt gtgtgtgtct gtatgtgttt aagtctgtgt 13021 gtgtttgtgt gtgtgtgtct ctgtgtgtgt gtctgtatct gtgtgtgttt gtgtctgtgt 13081 gtgtttgtgt gtgtgtctgt gtgtgtctgt gtgtgtgtct gtgtgtgtgt ttatgtgtct 13141 gtgtatgttt gtgtgtgtgt ttgtgtgtgt gtgtttgtgt ttatgtgtgt atgtctgtgt 13201 gtgtctgtgt gtctgtgtgt gtatgtgtct gtgtgtgttt atgtgtctgt gtgtgttcgt 13261 gtgtgtgtct gtgtgtgtgt gtttgtgtgt gtatgtctgt gtgtgtgtgt gtttatgtgt 13321 gtgtgtctgt gtgtgtttat gtctgtgtgt gtttgtgtgt gtgtgtctcg tgtgtgtgtg 13381 tctgtgtgta tctgtgtgtg tttgtgtgtg tgtgtgtctc tgtgtgtgtg tgtgtttgtg 13441 tatgtttgtg tgtgtgtgtg tgtgtgttgg gaatgcccag tctctgcagc tgctgaaagg 13501 ccctgaggca catgctgtca ggagctggct ctgtcctggg cagatatcac catctgtacc 13561 tcggttcagg ctgccgtggg caccaggccc tgtgctgggg gagtgctgag gagcctgaag 13621 ggactcaggg tcccgtgatg aggctgggct ggcacatgga ggaaagacag aatgtccaag 13681 acacaggcgc tgcttggcct ctgggtgtgg acctcaggag ggcttcctgg aggaggaggg 13741 atgctgggct tgccagaaag gaggcagctg ctcccaggat gagttctgaa catgctacct 13801 gagcccttcc ctcctcccgt gctctgttcc agacttggat gggggcccac ggggccggtg 13861 tgctgttgag ccaggactgt gctggcaccc cacagggagc cttggagccc tgcgtccagg 13921 aggccactgc actgctcact tgtggcccag cgcgtccttg gaaatctgtg gccctggagg 13981 aggaacagga gggccctggg accaggctcc cggggaacct gagctcagag gatgtgctgc 14041 cagcagggtg tacggagtgg agggtacaga cgcttgccta tctgccacag gaggactggg 14101 cccccacgtc cctgactagg ccggctcccc cagactcaga gggcagcagg agcagcagca 14161 gcagcagcag cagcaacaac aacaactact gtgccttggg ctgctatggg ggatggcacc WO 00/09525 PCT/US99/17712 EPI-109 741 14221 tctcagccct cccaggaaac acacagagct ctgggcccat cccagccctg gcctgtggcc 14281 tttcttgtga ccatcacagc ctggagaccc agcaaggagt tgcctgggtg ctggctggtc 14341 actgccagag acctgggctg catgaggacc tccagggcat gttgctccct tctgtcctca 14401 gcaaggctcg gtcctggaca ttctaggtcc ctgactcgcc agatgcatca tgtccatttt 14461 gggaaaatgg actgaaatt ctggagccct tgtctgagac tgaacctcct gagaaggggc 14521 ccctagcagc ggtcaagt cctgtctgga tggaggctgg aggctccccc ctcaacccct 14581 ctgctcagtg cctgtgggga gcagcctcta ccctcagcat cctggccaca agttcttcct 14641 tccattgtcc cttttc7:za tccctgacct ctctgagaag tggggtgtgg tctctcagct 14701 gttctgccct cataccctza aagggccagc ctgggcccag tggacacagg taaggcacca 14761 tgaccacctg gtgtgacctc tctgtgcctt actgaggcac ctttctagag attaaaaggg 14821 gcttgatggc tgttcccaaa gtgttgatgg ctgggagaag gggccagagg aggagtgagg 14881 ggtggggttt gtccagccct gggctttccg ggctctagag atagcatggt gtaggctcaa 14941 tgacagttct ggggacaaca agttggaggt tcaggggcag cttcaggaca gcaggatgga 15001 ggctcaggga caattcctgg gaggccagtg ccctcgttcc tccttgtcct catcctcccc 15061 cttgctccag gaaactgaga gctgagcctg gagcttccag acagtcagtg ctgggggtga 15121 ccatccagca gtgatggtgg cctgtgaagg gtcctgcttc tgtcctcagc ctctcatggg 15181 gtgggcttgt ggaggagctg tggtctggag agagtggcag ttggagcaga acgtgcctgc 15241 gtttgtttcc tagggctarc gtaacaaagt gccacaaaat ggttagctta gaaccacaga 15301 gatttgttgt ctcacaattc tgaagtccag aagttggaaa taaagatgtt ggcagtgttc 15361 ccaaccacat gttcttgggc tcccatgaaa cagaagttga tattaggcca aggaagcttc 15421 ccagacaaga ctttattaag tcttatgccc cgaaagtttg ggcagaagag agacggtgca 15481 ggaggaagaa ttcttggctg actccccaag gggaatgcat tgtggtgtct taaggagggt 15541 gacatacata atttatuagc tacatgagtg tcattgcaca tatggggtgg agcgaagggt 15601 gctcagacgc atgctaacac atacgttgca tgatcagaaa atggcagata agcccctccc 15661 tgggtgagga ctttagtatt atcataagac cagggtcatt ctcctggcct tgtgcacaag 15721 caggtgatgg agtcaactcc cgtcagtaag acttatggcg ggatgctgct tatcttagtt 15781 tatttcagac agttggcaag gtctggccag cgagtatggc acctggaggg tggtgctgca 15841 aggtctagtg gtcagcgggc acgtatggaa caatacgtta gtgggggtgg gccgagtccc 15901 atttatactc tctcagcagg gccatgctcc ctctgaaggc actagggaag gattagtttc 15961 aggcctctct tcagcttctg ttagtttctt ggcttgtgac accaaagctg taatctttct 16021 tttgttttgt ttttgtgacg gagttttgct cttgttgccc aggctggagt gcaatggcac 16081 aatctcggct cactgcaacc tcctcctccc aggtttaagc aattcttctg cctcagcctt 16141 tggagtagct gtgattacaa ggcacctgct accacgcctg gctagttttt gtatttttag 16201 tagagacggt gtttcgctat gttggccagg ctggtctcaa actcctgata tcaagtgatc 16261 cgtctgtctc tgcctcccaa agtgttggga ttacaggcat gagccaccgt gcctggccaa 16321 agttccagtc tttacaggga tttttccttg tgtgcatttc tgtgtccaaa tttccccttt 16381 ttaaaatcac aataatagtg aattaaggct ggccctaacg atttaatctt aacttgatca 16441 tctgcaaaga cactatttcc atataaggtc acattcacag ctactggggt taggacttca 16501 acctagaggg cctgacttct ggcccaacac atcatggccc atcccagcat gccccatccc 16561 cttcctgggt gccccaggca gatcacagga gggcctgact gctgggcttt gggctgacat 16621 tgggatcatc tgcctagtta gggctgtgac cagactgaga taggaggtgg gacctgactc 16681 ctgaggcagg gcttgaactc tggaccagat tacagactag ctgaaacagg caaaagcacc 16741 cctccataag acacacccac tggtgccaag tgagtttgcc gttctcatgg taacagctgg 16801 aaattactgc ccctttccat ggcaatgacc tgaaagttac cacccctttt ctagaaattt 16861 ctaaataacc tcctccttaa tttgtatata gttacaagtg ggtataaata tgtgtgcaga 16921 actgcctctg agctgctact ctgggctgac tgcctatggg gcatccctgc tccataagga 16981 gcagtacctc tgctgccact gtgcacagct gcttaaataa aagttgctct ctaataccac 17041 cgactcgccc ttgaattctt tcctgggtga agc (2) INFORMATION FOR SEQ ID NO:2567: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 2041 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2567: 1 aattcagaac tcctcagccc cccaagaaaa aaatatcccc gtggaaattc ctttttaatg 61 accgaggcgg gggaaatatg cgtctctgga tggccagtga ctcgcagccc ccttccccga 121 taggaagggc ctgcgcgtcc ggggaccctt cgcttcccct tctgctgcgc gacctccctg 181 gcccctcgga gatctccatg gcgacgccgc gcgcgcccca caacaggaaa gccttaggcg 241 gcgcggcttg gtgctcggag acttaagagt acccagcccc tcgacgtggt ggatgtcgag 301 tcttggggtc acacgcacag gcggtggcca agcaaacacc cgctcatatt tagtgcatga 361 gcctgggttc gagttgccgg agcctcgcgc gtagggcagg ggttcgagcg ccccttctcc 421 ctgcctcgcc tctgcgccctg ggggctgctg cctcagtttc ccagcgacag gcagggattt 481 cgagcgtccc cctcccctcc ctcgtcaaga tccaagctag ctgcctcagt ttccccgcgg 541 agcctgggac gccagcggag gggctcggcg cgtagggatc acgcagcttc cttccttttt 601 ctgggagctg taaagacgcc tccgccaacg ccgaaagggg aagcgaggag gccgccgggg 661 tgagtgccct cgggtgtaaa gagaggacgc cgatttcccc ggacgtggtg agaccgcgct 721 tcgtcactcc cacggttac ggtcgccggg aggtgccgg ctctgctctg gccgcttctc WO 00/09525 PCT/US99/17712 EPI-109 742 781 gagaaatgcc cgtgtcauct aggtgtggac gtgacctagg gggaggggca tccctcagtg 841 gagggagccc ggggaggatt cctgggcccc cacccaggca gggggctcat ccactcgatt 901 aaagaggcct gcgtaagctg gagagggagg acttgagttc ggaccccctc gcagcctgga 961 gtctcagttt accgctttgt gaaatggaca caataacagt ctccactctc cggggaagtt 1021 ggcagtattt aaaagtactt aataaacgcc ttagcgcggt gtagaccgtg attcaagctt 1081 agcctggccg ggaaacggga ggcgtggagg ccgggagcag cccccggggt catcgccctg 1141 ccaccgccgc ccgattgctt tagcttggaa attccggagc tgaagcggcc agcgagggag 1201 gatgaccctc tcggcccggg caccctgtca gtccggaaat aactgcagca tttgttccgg 1261 aggggaaggc gcgaggtttc cgggaaagca gcaccgcccc ttggccccca ggtggctagc 1321 gctataaagg atcacgcgcc ccagtcgacg ctgagctcct ctgctactca gagttgcaac 1381 ctcagcctcg ctatggctcc cagcagcccc cggcccgcgc tgcccgcact cctggtcctg 1441 ctcggggctc tgttcccagg tgagtcgggg tggggattgc cgtcgggcca gttctccgaa 1501 gcccgggagg accggctccc gggtcaggtc atgcatgctt aggtagctgt ttatgggaag 1561 gaggggctag agacagcgat tgaaagcaac agccagtagg ttcgaatcca gaccctgcat 1621 acctccacgt gtggccttgg gctatagatt gcagctttaa aaaagggtag ggggttggag 1681 atggagggga ggggcgggcc tcgttttgtt gcccaggccg gtcttgaact ccgggggtct 1741 agccttacct cctgcctcag cctcccgagt agctgggatg aggtgtgaac cacgccttgc 1801 ttggctagat tgcgtctctt acagtttctc agctgtaaaa cgggaaacgt tatagcggcc 1861 acctggcagg gtatcttggc ccagcgcagc acctggcccc aggactcgat catgatggtt 1921 tgggaacttg gctctgtgcc aacccaacaa ggcttaaggg acccccaccc ccctcaagat 1981 gtatattctg ttcctcatcc tctctgcccc tggggaagtc cagggctgct tctacttggg 2041 gg (2) INFORMATION FOR SEQ ID NO:2568: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 2941 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2568: 1 gcgccccagt cgacgctgag ctcctctgct actcagagtt gcaacctcag cctcgctatg 61 gctcccagca gcccccggcc cgcgctgccc gcactcctgg tcctgctcgg ggctctgttc 121 ccaggacctg gcaatgccca gacatctgtg tccccctcaa aagtcatcct gccccgggga 181 ggctccgtgc tggtgacatg cagcacctcc tgtgaccagc ccaagttgtt gggcatagag 241 accccgttgc ctaaaaagga gttgctcctg cctgggaaca accggaaggt gtatgaactg 301 agcaatgtgc aagaagatag ccaaccaatg tgctattcaa actgccctga tgggcagtca 361 acagctaaaa ccttcctcac cgtgtactgg actccagaac gggtggaact ggcacccctc 421 ccctcttggc agccagtggg caagaacctt accctacgct gccaggtgga gggtggggca 481 ccccgggcca acctcaccgt ggtgctgctc cgtggggaga aggagctgaa acgggagcca 541 gctgtggggg agcccgctga ggtcacgacc acggtgctgg tgaggagaga tcaccatgga 601 gccaatttct cgtgccgcac tgaactggac ctgcggcccc aagggctgga gctgtttgag 661 aacacctcgg ccccctacca gctccagacc tttgtcctgc cagcgactcc cccacaactt 721 gtcagccccc gggtcctaga ggtggacacg caggggaccg tggtctgttc cctggacggg 781 ctgttcccag tctcggaggc ccaggtccac ctggcactgg gggaccagag gttgaacccc 841 acagtcacct atggcaacga ctccttctcg gccaaggcct cagtcagtgt gaccgcagag 901 gacgagggca cccagcggct gacgtgtgca gtaatactgg ggaaccagag ccaggagaca 961 ctgcagacag tgaccatcta cagctttccg gcgcccaacg tgattctgac gaagccagag 1021 gtctcagaag ggaccgaggt gacagtgaag tgtgaggccc accctagagc caaggtgacg 1081 ctgaatgggg ttccagccca gccactgggc ccgagggccc agctcctgct gaaggccacc 1141 ccagaggaca acgggcgcag cttctcctgc tctgcaaccc tggaggtggc cggccagctt 1201 atacacaaga accagacccg ggagcttcgt gtcctgtatg gcccccgact ggacgagagg 1261 gattgtccgg gaaactggac gtggccagaa aattcccagc agactccaat gtgccaggct 1321 tgggggaacc cattgcccga gctcaagtgt ctaaaggatg gcactttccc actgcccatc 1381 ggggaatcag tgactgtcac tcgagatctt gagggcacct acctctgtcg ggccaggagc 1441 actcaagggg aggtcacccg cgaggtgacc gtgaatgtgc tctccccccg gtatgagatt 1501 gtcatcatca ctgtggtagc aqccgcagtc ataatgggca ctgcaggcct cagcacgtac 1561 ctctataacc gccagcggaa gatcaagaaa tacagactac aacaggccca aaaagggacc 1621 cccatgaaac cgaacacaca agccacgcct ccctgaacct atcccgggac agggcctctt 1681 cctcggcctt cccatattgg tggcagtggt gccacactga acagagtgga agacatatgc 1741 catgcagcta cacctaccgg ccctgggacg ccggaggaca gggcattgtc ctcagtcaga 1801 tacaacagca tttggggcca tggtacctgc acacctaaaa cactaggcca cgcatctgat 1861 ctgtagtcac atgactaagc caagaggaag gagcaagact caagacatga ttgatggatg 1921 ttaaagtcta gcctgatgag aggggaagtg gtgggggaga catagcccca ccatgaggac 1981 atacaactgg gaaatactga aacttgctgc ctattgggta tgctgaggcc cacagactta 2041 cagaagaagt ggccctccat agacatgtgt agcatcaaaa cacaaaggcc cacacttcct 2101 gacggatgcc agcttgggca ctgctgtcta ctgaccccaa cccttgatga tatgtattta 2161 ttcatttgtt attttaccag ctatttattg agtgtctttt atgtaggcta aatgaacata 2221 ggtctctggc ctcacggagc tcccagtcca tgtcacattc aaggtcacca ggcacagttg 2281 tacaggttgt acactgcagg agagtgcctg gcaaaaagat caaatggggc tgggacttct WO 00/09525 PCT/US99/17712 EPI-109 743 2341 cattggccaa cctgcctttc cccagaagga gtgatttttc tatcggcaca aaagcactat 2401 atggactggt aatggttcac aggttcagag attacccagt gaggcctat tcctcccttc 2461 cccccaaaac tgacaccttt gttagccacc tccccaccca catacatttc tgccagtgtt 2521 cacaatgaca ctcagcggtc atgtctggac atgagtgccc agggaazatg cccaagctat 2581 gccttgtcct cttgtcctgt ttgcatttca ctgggagctt gcactattgc agctccagtt 2641 tcctgcagtg atcagggtcc tgcaagcagt ggggaagggg gccaagagtat tggaggactc 2701 cctcccagct ttggaagggt catccgcgtg tgtgtgtgtg tgtatgzgta gacaagctct 2761 cgctctgtca cccaggctgg agtgcagtgg tgcaatcatg gttcaczgca gtcttgacct 2821 tttgggctca agtgatcctc ccacctcagc ctcctgagta gctgggacca taggctcaca 2881 acaccacacc tggcaaattt gatttttttt ttttttttca gagacggggt ctcgcaacat 2941 tgcccagact tcctttgtgt tagttaataa agctttctca actgcc (2) INFORMATION FOR SEQ ID NO:2569: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 3001 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2569: 1 gctataagga tcacgcgccc cagtcgacgc tgagctcctc tgctactcag agttgcaacc 61 tcagcctcgc tatggctccc agcagccccc ggcccgcgct gcccgcactc ctggtcctgc 121 tcggggctct gttcccagga cctggcaatg cccagacatc tgtgtccccc tcaaaagtca 181 tcctgccccg gggaggctcc gtgctggtga catgcagcac ctcctgtgac cagcccaagt 241 tgttgggcat agagaccccg ttgcctaaaa aggagttgct cctgcctggg aacaaccgga 301 aggtgtatga actgagcaat gtgcaagaag atagccaacc aatgtgcrat tcaaactgcc 361 ctgatgggca gtcaacagct aaaaccttcc tcaccgtgta ctggaccca gaacgggtgg 421 aactggcacc cctcccctct tggcagccag tgggcaagaa ccttacccta cgctgccagg 481 tggagggtgg ggcaccccgg gccaacctca ccgtggtgct gctccgtggg gagaaggagc 541 tgaaacggga gccagctgtg ggggagcccg ctgaggtcac gaccacggtg ctggtgagga 601 gagatcacca tggagccaat ttctcgtgcc gcactgaact ggacctgcgg ccccaagggc 661 tggagctgtt tgagaacacc tcggccccct accagctcca gacctttgtc ctgccagcga 721 ctcccccaca acttgtcagc ccccgggtcc tagaggtgga cacgcagggg accgtggtct 781 gttccctgga cgggctgttc ccagtctcgg aggcccaggt ccacctggca ctgggggacc 841 agaggttgaa ccccacagtc acctatggca acgactcctt ctcggccaag gcctcagtca 901 gtgtgaccgc agaggacgag ggcacccagc ggctgacgtg tgcagtaata ctggggaacc 961 agagccagga gacactgcag acagtgacca tctacagctt tccggcgccc aacgtgattc 1021 tgacgaagcc agaggtctca gaagggaccg aggtgacagt gaagtgtgag gcccacccta 1081 gagccaaggt gacgctgaat ggggttccag cccagccact gggcccgagg gcccagctcc 1141 tgctgaaggc caccccagag gacaacgggc gcagcttctc ctgctctgca accctggagg 1201 tggccggcca gcttatacac aagaaccaga cccgggagct tcgtgtcctg tatggccccc 1261 gactggacga gagggattgt ccgggaaact ggacgtggcc agaaaattcc cagcagactc 1321 caatgtgcca ggcttggggg aacccattgc ccgagctcaa gtgtctaaag gatggcactt 1381 tcccactgcc catcggggaa tcagtgactg tcactcgaga tcttgagggc acctacctct 1441 gtcgggccag gagcactcaa ggggaggtca cccgcaaggt gaccgtgaat gtgctctccc 1501 cccggtatga gattgtcatc atcactgtgg tagcagccgc agtcataatg ggcactgcag 1561 gcctcagcac gtacctctat aaccgccagc ggaagatcaa gaaatacaga ctacaacagg 1621 cccaaaaagg gacccccatg aaaccgaaca cacaagccac gcctccctga acctatcccg 1681 ggacagggcc tcttcctcgg ccttcccata ttggtggcag tggtgccaca ctgaacagag 1741 tggaagacat atgccatgca gctacaccta ccggccctgg gacgccggag gacagggcat 1801 tgtcctcagt cagatacaac agcatttggg gccatggtac ctgcacacct aaaacactag 1861 gccacgcatc tgatctgtag tcacatgact aagccaagag gaaggagcaa gactcaagac 1921 atgattgatg gatgttaaag tctagcctga tgagagggga agtggtgggg gagacatagc 1981 cccaccatga ggacatacaa ctgggaaata ctgaaacttg ctgcctattg ggtatgctga 2041 ggccccacag acttacagaa gaagtggccc tccatagaca tgtgtagcat caaaacacaa 2101 aggcccacac ttcctgacgg atgccagctt gggcactgct gtctactgac cccaaccctt 2161 gatgatatgt atttattcat ttgttatttt accagctatt tattgagtgt cttttatgta 2221 ggctaaatga acataggtct ctggcctcac ggagctccca gtccatgtca cattcaaggt 2281 caccaggtac agttgtacag gttgtacact gcaggagagt gcctggcaaa aagatcaaat 2341 ggggctggga cttctcattg gccaacctgc ctttccccag aaggagtgat ttttctatcg 2401 gcacaaaagc actatatgga ctggtaatgg ttcacaggtt cagagattac ccagtgaggc 2461 cttattcctc ccttcccccc aaaactgaca cctttgttag ccacctcccc acccacatac 2521 atttctgcca gtgttcacaa tgacactcag cggtcatgtc tggacatgag tgcccaggga 2581 atatgcccaa gctatgcctt gtcctcttgt cctgtttgca tttcacrggg agcttgcact 2641 attgcagctc cagtttcctg cagtgatcag ggtcctgcaa gcagtgggga agggggccaa 2701 ggtattggag gactccctcc cagctttgga agcctcatcc gcgtgtatgt gtgtgtgtgt 2761 atgtgtagac aagctctcgc tctgtcaccc aggctggagt gcagtggtgc aatcatggtt 2821 cactgcagtc ttgacctttt gggctcaagt gatcctccca cctcagcctc ctgagtagct 2881 gggaccatag gctcacaaca ccacacctgg caaatttgat ttttttzttt tttttcagag 2941 acggggtctc gcaacattgc ccagacttcc tttgtgttag ttaataaagc tttctcaact WO 00/09525 PCT/US99/17712 EPI-109 744 3001 gcc (2) INFORMATION FOR SEQ ID NO:2570: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1801 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2570: 1 ctcagcctcg ctatggctcc cagcagcccc cggcccgcgc tgcccgcact cctggtcctg 61 ctcggggctc tgttcccagg acctggcaat gcccagacat ctgtgtcccc ctcaaaagtc 121 atcctgcccc ggggaggctc cgtgctggtg acatgcagca cctcctgtga ccagcccaag 181 ttgttgggca tagagacccc gttgcctaaa aaggagttgc tcctgcctgg gaacaaccgg 241 aaggtgtatg aactgagcaa tgtgcaagaa gatagccaac caatgtgcta ttcaaactgc 301 cctgatgggc agtcaacagc taaaaccttc ctcaccgtgt actggactcc agaacgggtg 361 gaactggcac ccctcccctc ttggcagcca gtgggcaaga accttaccct acgctgccag 421 gtggagggtg gggcaccccg ggccaacctc accgtggtgc tgctccgtgg ggagaaggag 481 ctgaaacggg agccagctgt gggggagccc gctgaggtca cgaccacggt gctggtgagg 541 agagatcacc atggagccaa tttctcgtgc cgcactgaac tggacctgcg gccccaaggg 601 ctggagctgt ttgagaacac ctcggccccc taccagctcc agacctttgt cctgccagcg 661 actcccccac aacttgtcag cccccgggtc ctagaggtgg acacgcaggg gaccgtggtc 721 tgttccctgg acgggctgtt cccagtctcg gaggcccagg tccacctggc actgggggac 781 cagaggttga accccacagt cacctatggc aacgactcct tctcggccaa ggcctcagtc 841 agtgtgaccg cagaggacga gggcacccag cggctgacgt gtgcagtaat actggggaac 901 cagagccagg agacactgca gacagtgacc atctacagct ttccggcgcc caacgtgatt 961 ctgacgaagc cagaggtctc agaagggacc gaggtgacag tgaagtgtga ggcccaccct 1021 agagccaagg tgacgctgaa tggggttcca gcccagccac tgggcccgag ggcccagctc 1081 ctgctgaagg ccaccccaga ggacaacggg cgcagcttct cctgctctgc aaccctggag 1141 gtggccggcc agcttataca caagaaccag acccgggagc ttcgtgtcct gtatggcccc 1201 cgactggacg agagggattg tccgggaaac tggacgtggc cagaaaattc ccagcagact 1261 ccaatgtgcc aggcttgggg gaacccattg cccgagctca agtgtctaaa ggatggcact 1321 ttcccactgc ccatcgggga atcagtgact gtcactcgag atcttgaggg cacctacctc 1381 tgtcgggcca ggagcactca aggggaggtc acccgcgagg tgaccgtgaa tgtgctctcc 1441 ccccggtatg agattgtcat catcactgtg gtagcagccg cagtcataat gggcactgca 1501 ggcctcagca cgtacctcta taaccgccag cggaagatca agaaatacag actacaacag 1561 gcccaaaaag ggacccccat gaaaccgaac acacaagcca cgcctccctg aacctatccc 1621 gggacagggc ctcttcctcg gccttcccat attggtggca gtggtgccac actgaacaga 1681 gtggaagaca tatgccatgc agctacacct accggccctg ggacgccgga ggacagggca 1741 ttgtcctcag tcagatacaa cagcatttgg ggccatggta cctgcacacc taaaacacta 1801 ggccacgcat ctgatctgta gtcacatgac taagccaaga ggaagg (2) INFORMATION FOR SEQ ID NO:2571: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 9784 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2571: 1 aattcagaac tcctcagccc cccaagaaaa aaatatcccc gtggaaattc ctttttaatg 61 accgaggcgg gggaaatatg cgtctctgga tggccagtga ctcgcagccc ccttccccga 121 taggaagggc ctgcgcgtcc ggggaccctt cgcttcccct tctgctgcgc gacctccctg 181 gcccctcgga gatctccatg gcgacgccgc gcgcgcccca caacaggaaa gccttaggcg 241 gcgcggcttg gtgctcggag acttaagagt acccagcccc tcgacgtggt ggatgtcgag 301 tcttggggtc acacgcacag gcggtggcca agcaaacacc cgctcatatt tagtgcatga 361 gcctgggttc gagttgccgg agcctcgcgc gtagggcagg ggttcgagcg ccccttctcc 421 ctgcctcgcc tctgcgcctg ggggctgctg cctcagtttc ccagcgacag gcagggattt 481 cgagcgtccc cctcccctcc ctcgtcaaga tccaagctag ctgcctcagt ttccccgcgg 541 agcctgggac gccagcggag gggctcggcg cgtagggatc acgcagcttc cttccttttt 601 ctgggagctg taaagacgcc tccgccaacg ccgaaagggg aagcgaggag gccgccgggg 661 tgagtgccct cgggtgtaga gagaggacgc cgatttcccc ggacgtggtg agaccgcgct 721 tcgtcactcc cacggttagc ggtcgccggg aggtgcctgg ctctgctctg gccgcttctc 781 gagaaatgcc cgtgtcagct aggtgtggac gtgacctagg gggaggggca tccctcagtg 841 gagggagccc ggggaggatt cctgggcccc cacccaggca gggggccat ccactcgatt 901 aaagaggcct gcgtaagctg gagagggagg acttgagttc ggaccccctc gcagcctgga 961 gtctcagttt accgctttgt gaaatggaca caataacagt ctccactctc cggggaagtt 1021 ggcagtattt aaaagtactt aataaacgcc ttagcgcggt gtagaccgtg attcaagctt 1081 agcctggccg ggaaacggga ggcgtggagg ccgggagcag cccccggggt catcgccctg 1141 ccaccgccgc ccgattgctt tagcttggaa attccggagc tgaagcggcc agcgagggag 1201 gatgaccctc tcggcccggg caccctgtca gtccggaaat aactgcagca tttgttccgg WO 00/09525 PCT/US99/17712 EPI-109 745 1261 aggggaaggc gcgagg:zc cgggaaagca gcaccgcccc ttggccccca ggtggctagc 1321 gctataaagg atcacgcccc ccagtcgacg ctgagctcct ctgctactca gagttgcaac 1381 ctcagcctcg ctatggczcc cagcagcccc cggcccgcgc tgcccgcact cctggtcctg 1441 ctcggggctc tgttcccagg tgagtcgggg tggggattgc cgtcgggcca gttctccgaa 1501 gcccgggagg accggctccc gggtcaggtc atgcatgctt aggtagctgt ttatgggaag 1561 gaggggctag agacagcaat tgaaagcaac agccagtagg ttcgaatcca gaccctgcat 1621 acctccacgt gtggcctzgg gctatagatt gcagctttaa aaaagggtag ggggttggag 1681 atggagggga ggggcggacc tcgttttgtt gcccaggccg gtcttgaact ccgggggtct 1741 agccttacct cctgcctcag cctcccgagt agctgggatg aggtgtgaac cacgccttgc 1801 ttggctagat tgcgtctc-t acagtttctc agctgtaaaa cgggaaacgt tatagcggcc 1861 acctggcagg gtatcttagc ccagcgcagc acctggcccc aggactcgat catgatggtt 1921 tgggaacttg gctctgtacc aacccaacaa ggettaaggg acccccaccc ccctcaagat 1981 gtatattctg ttcctcatcc tctctgcccc tggggaagtc cagggctgct tctacttggg 2041 gg 1 gcgccccagt cgacgctgag ctcctctgct actcagagtt gcaacctcag cctcgctatg 61 gctcccagca gcccccggcc cgcgctgccc gcactcctgg tcctgctcgg ggctctgttc 121 ccaggacctg gcaatgccca gacatctgtg tccccctcaa aaqtcatcct gccccgggga 181 ggctccgtgc tggtgacatg cagcacctcc tgtgaccagc ccaagttgtt gggcatagag 241 accccgttgc ctaaaaagga gttgctcctg cctgggaaca accggaaggt gtatqaactg 301 agcaatgtgc aagaagatag ccaaccaatg tgctattcaa actgccctga tgggcagtca 361 acagctaaaa ccttcctcac cgtgtactgg actccagaac gggtggaact ggcacccctc 421 ccctcttggc agccagtggg caagaacctt accctacgct gccaggtgga gggtggggca 481 ccccgggcca acctcaccgt ggtgctgctc cgtggggaga aggagctgaa acgggagcca 541 gctgtggggg agcccgct.ga ggtcacgacc acggtgctgg tgaggagaga tcaccatgga 601 gccaatttct cgtgccgcac tgaactggac ctgcggcccc aagggctgga gctgtttgag 661 aacacctcgg ccccctacca gctccagacc tttgtcctgc cagcgactcc cccacaactt 721 gtcagccccc gggtcctaga ggtggacacg caggggaccg tggtctgttc cctggacggg 781 ctgttcccag tctcggaggc ccaggtccac ctggcactgg gggaccagag gttgaacccc 841 acagtcacct atggcaacga ctccttctcg gccaaggcct cagtcagtgt gaccgcagag 901 gacgagggca cccagcggct gacgtgtgca gtaatactgg ggaaccagag ccaggagaca 961 ctgcagacag tgaccatcta cagctttccg gcgcccaacg tgattctgac gaagccagag 1021 gtctcagaag ggaccgaggt gacagtgaag tgtgaggccc accctagagc caaggtgacg 1081 ctgaatgggg ttccagccca gccactgggc ccgagggccc agctcctgct gaaggccacc 1141 ccagaggaca acgggcgcag cttctcctgc tctgcaaccc tggaggtggc cggccagctt 1201 atacacaaga accagacccq ggagcttcgt gtcctgtatg gcccccgact ggacgagagg 1261 gattgtccgg gaaactggac gtggccagaa aattcccagc agactccaat gtgccaggct 1321 tgggggaacc cattgcccga gctcaagtgt ctaaaggatg gcactttccc actgcccatc 1381 ggggaatcag tgactgtcac tcgagatctt gagggcacct acctctgtcg ggccaggagc 1441 actcaagggg aggtcacccg cgaggtgacc gtgaatgtgc tctccccccg gtatgagatt 1501 gtcatcatca ctgtggtagc agccgcagtc ataatgggca ctgcaggcct cagcacgtac 1561 ctctataacc gccagcggaa gatcaagaaa tacagactac aacaggccca aaaagggacc 1621 cccatgaaac cgaacacaca agccacgcct ccctgaacct atcccgggac agggcctctt 1681 cctcggcctt cccatattgg tggcagtggt gccacactga acagagtgga agacatatgc 1741 catgcagcta cacctaccgg ccctgggacg ccggaggaca gggcattgtc ctcagtcaga 1801 tacaacagca tttggggcca tggtacctgc acacctaaaa cactaggcca cgcatctgat 1861 ctgtagtcac atgactaagc caagaggaag gagcaagact caagacatga ttgatggatg 1921 ttaaagtcta gcctgatgag aggggaagtg gtgggggaga catagcccca ccatgaggac 1981 atacaactgg gaaatactga aacttgctgc ctattgggta tgctgaggcc cacagactta 2041 cagaagaagt ggccctccat agacatgtgt agcatcaaaa cacaaaggcc cacacttcct 2101 gacggatgcc agcttgggca ctgctgtcta ctgaccccaa cccttgatga tatgtattta 2161 ttcatttgtt attttaccag ctatttattg agtgtctttt atgtaggcta aatgaacata 2221 ggtctctggc ctcacggagc tcccagtcca tgtcacattc aaggtcacca ggtacagttg 2281 tacaggttgt acactgcagg agagtgcctg gcaaaaagat caaatggggc tgggacttct 2341 cattggccaa cctgcctttc cccagaagga gtgatttttc tatcggcaca aaagcactat 2401 atggactggt aatggttcac aggttcagag attacccagt gaggccttat tcctcccttc 2461 cccccaaaac tgacaccttt gttagccacc tccccaccca catacatttc tgccagtgtt 2521 cacaatgaca ctcagcggtc atgtctggac atgagtgccc agggaatatg cccaagctat 2581 gccttgtcct cttgtcctgt ttgcatttca ctgggagctt gcactattgc agctccagtt 2641 tcctgcagtg atcagggtcc tgcaagcagt ggggaagggg gccaaggtat tggaggactc 2701 cctcccagct ttggaagggt catccgcgtg tgtgtgtgtg tgtatgtgta gacaagctct 2761 cgctctgtca cccaggctgg agtgcagtgg tgcaatcatg gttcactgca gtcttgacct 2821 tttgggctca agtgatcctc ccacctcagc ctcctgagta gctgggacca taggctcaca 2881 acaccacacc tggcaaattt gatttttttt ttttttttca gagacggggt ctcgcaacat 2941 tgcccagact tcctttgtgt tagttaataa agctttctca actgcc 1 gctataagga tcacgcgccc cagtcgacgc tgagctcctc tgctactcag agttgcaacc 61 tcagcctcgc tatggctccc agcagccccc ggcccgcgct gcccgcactc ctggtcctgc 121 tcggggctct gttcccagga cctggcaatg cccagacatc tgtgtccccc tcaaaagtca 181 tcctgccccg gggaggctcc gtgctggtga catgcagcac ctcctgtgac cagcccaagt WO 00/09525 PCTIUS99/17712 EPI-109 746 241 tgttgggcat agagaccccg ttgcctaaaa aggagttgct cctgcctggg aacaaccgga 301 aggtgtatga actgagcaat gtgcaagaag atagccaacc aatgtgctat tcaaactgcc 361 ctgatgggca gtcaacagct aaaaccttcc tcaccgtgta ctggactcca gaacgggtgg 421 aactggcacc cctccccrct tggcagccag tgggcaagaa ccttacccta cgctqccagg 481 tggagggtgg ggcaccccgg gccaacctca ccgtggtgct gctccgtggg gagaaggagc 541 tgaaacggga gccagctgtg ggggagcccg ctgaggtcac gaccacggtg ctggtgagga 601 gagatcacca tggagccaat ttctcgtgcc gcactgaact ggacctgcgg ccccaagggc 661 tggagctgtt tgagaacacc tcggccccct accagctcca gacctttgtc ctgccagcga 721 ctcccccaca acttgtcagc ccccgggtcc tagaggtgga cacgcagggg accgtggtct 781 gttccctgga cgggctgttc ccagtctcgg aggcccaggt ccacctggca ctgggggacc 841 agaggttgaa ccccacagtc acctatggca acgactcctt ctcggccaag gcctcagtca 901 gtgtgaccgc agaggacgag ggcacccagc ggctgacgtg tgcagtaata ctggggaacc 961 agagccagga gacactgcag acagtgacca tctacagctt tccggcgccc aacgtgattc 1021 tgacgaagcc agaggtctca gaagggaccg aggtgacagt gaagtgtgag gcccacccta 1081 gagccaaggt gacgctgaat ggggttccag cccagccact gggcccgagg gcccagctcc 1141 tgctgaaggc caccccagag gacaacgggc gcagcttctc ctgctctgca accctggagg 1201 tggccggcca gcttatacac aagaaccaga cccgggagct tcgtgtcctg tatggccccc 1261 gactggacga gagggattgt ccgggaaact ggacgtggcc agaaaattcc cagcagactc 1321 caatgtgcca ggcttggggg aacccattgc ccgagctcaa gtgtctaaag gatggcactt 1381 tcccactgcc catcggggaa tcagtgactg tcactcgaga tcttgagggc acctacctct 1441 gtcgggccag gagcactcaa ggggaggtca cccgcaaggt gaccgtgaat gtgctctccc 1501 cccggtatga gattgtcatc atcactgtgg tagcagccgc agtcataatg ggcactgcag 1561 gcctcagcac gtacctctat aaccgccagc ggaagatcaa gaaatacaga ctacaacagg 1621 cccaaaaagg gacccccatg aaaccgaaca cacaagccac gcctccctga acctatcccg 1681 ggacagggcc tcttcctcgg ccttcccata ttggtggcag tggtgccaca ctgaacagag 1741 tggaagacat atgccatgca gctacaccta ccggccctgg gacgccggag gacagggcat 1801 tgtcctcagt cagatacaac agcatttggg gccatggtac ctgcacacct aaaacactag 1861 gccacgcatc tgatctgtag tcacatgact aagccaagag gaaggagcaa gactcaagac 1921 atgattgatg gatgttaaag tctagcctga tgagagggga agtggtgggg gagacatagc 1981 cccaccatga ggacatacaa ctgggaaata ctgaaacttg ctgcctattg ggtatgctga 2041 ggccccacag acttacagaa gaagtggccc tccatagaca tgtgtagcat caaaacacaa 2101 aggcccacac ttcctgacgg atgccagctt gggcactgct gtctactgac cccaaccctt 2161 gatgatatgt atttattcat ttgttatttt accagctatt tattgagtgt cttttatgta 2221 ggctaaatga acataggtct ctggcctcac ggagctccca gtccatgtca cattcaaggt 2281 caccaggtac agttgtacag gttgtacact gcaggagagt gcctggcaaa aagatcaaat 2341 ggggctggga cttctcattg gccaacctgc ctttccccag aaggagtgat ttttctatcg 2401 gcacaaaagc actatatgga ctggtaatgg ttcacaggtt cagagattac ccagtgaggc 2461 cttattcctc ccttcccccc aaaactgaca cctttgttag ccacctcccc acccacatac 2521 atttctgcca gtgttcacaa tgacactcag cggtcatgtc tggacatgag tgcccaggga 2581 atatgcccaa gctatgcctt gtcctcttgt cctgtttgca tttcactggg agcttgcact 2641 attgcagctc cagtttcctg cagtgatcag ggtcctgcaa gcagtgggga agggggccaa 2701 ggtattggag gactccccc cagctttgga agcctcatcc gcgtgtgtgt gtgtgtgtgt 2761 atgtgtagac aagctctcgc tctgtcaccc aggctggagt gcagtggtgc aatcatggtt 2821 cactgcagtc ttgacctttt gggctcaagt gatcctccca cctcagcctc ctgagtagct 2881 gggaccatag gctcacaaca ccacacctgg caaatttgat tttttttttt tttttcagag 2941 acggggtctc gcaacattgc ccagacttcc tttgtgttag ttaataaagc tttctcaact 3001 gcc 1 ctcagcctcg ctatggctcc cagcagcccc cggcccgcgc tgcccgcact cctggtcctg 61 ctcggggctc tgttcccagg acctggcaat gcccagacat ctgtgtcccc ctcaaaagtc 121 atcctgcccc ggggaggctc cgtgctggtg acatgcagca cctcctgtga ccagcccaag 181 ttgttgggca tagagacccc gttgcctaaa aaggagttgc tcctgcctgg gaacaaccgg 241 aaggtgtatg aactgagcaa tgtgcaagaa gatagccaac caatgtgcta ttcaaactgc 301 cctgatgggc agtcaacagc taaaaccttc ctcaccgtgt actggactcc agaacgggtg 361 gaactggcac ccctcccctc ttggcagcca gtgggcaaga accttaccct acgctgccag 421 gtggagggtg gggcaccccg ggccaacctc accgtggtgc tgctccgtgg ggagaaggag 481 ctgaaacggg agccagctgt gggggagccc gctgaggtca cgaccacggt gctggtgagg 541 agagatcacc atggagccaa tttctcgtgc cgcactgaac tggacctgcg gccccaaggg 601 ctggagctgt ttgagaacac ctcggccccc taccagctcc agacctttgt cctgccagcg 661 actcccccac aacttgtcag cccccgggtc ctagaggtgg acacgcaggg gaccgtggtc 721 tgttccctgg acgggctgtt cccagtctcg gaggcccagg tccacczggc actgggggac 781 cagaggttga accccacagt cacctatggc aacgactcct tctcggccaa ggcctcagtc 841 agtgtgaccg cagaggacga gggcacccag cggctgacgt gtgcagtaat actggggaac 901 cagagccagg agacactgca gacagtgacc atctacagct ttccggcgcc caacgtgatt 961 ctgacgaagc cagaggtctc agaagggacc gaggtgacag tgaagtgtga ggcccaccct 1021 agagccaagg tgacgctgaa tggggttcca gcccagccac tgggcccgag ggcccagctc 1081 ctgctgaagg ccaccccaga ggacaacggg cgcagcttct cctgctctgc aaccctggag 1141 gtggccggcc agcttataca caagaaccag acccgggagc ttcgtgtcct gtatggcccc 1201 cgactggacg agagggattg tccgggaaac tggacgtggc cagaaaatc ccagcagact WO 00/09525 PCT/US99/17712 EPI-109 747 1261 ccaatgtgcc aggcttgggg gaacccattg cccgagctca agtgtctaaa ggatggcact 1321 ttcccactgc ccatcgggga atcagtgact gtcactcgag atcttgaggg cacctacctc 1381 tgtcgggcca ggagcactca aggggaggtc acccgcgagg tgaccgtgaa tgtgctctcc 1441 ccccggtatg agattgtcat catcactgtg gtagcagccg cagtcataat gggcactgca 1501 ggcctcagca cgtacctcta taaccgccag cggaagatca agaaatacag actacaacag 1561 gcccaaaaag ggacccccat gaaaccgaac acacaagcca cgcctccctg aacctatccc 1621 gggacagggc ctcttcctcg gccttcccat attggtggca gtggtgccac actgaacaga 1681 gtggaagaca tatgccatgc agctacacct accggccctg ggacgccgga ggacagggca 1741 ttgtcctcag tcagatacaa cagcatttgg ggccatggta cctgcacacc taaaacacta 1801 ggccacgcat ctgatctgta gtcacatgac taagccaaga ggaagg (2) INFORMATION FOR SEQ ID NO:2572: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 4681 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2572: 1 gaattcctgc cactcttcct gcaacggccc aggagctcag agctccacat ctgaccttct 61 agtcatgacc aggaccaggg cagcactcct cctgttcaca gccttagcaa cttctctagg 121 tttcaacttg gacacagagg agctgacagc cttccgtgtg gacagcgctg ggtttggaga 181 cagcgtggtc cagtatgcca actcctgggt ggtggttgga gccccccaaa agataacagc 241 tgccaaccaa acgggtggcc tctaccagtg tggctacagc actggtgcct gtgagcccat 301 cggcctgcag gtgcccccgg aggccgtgaa catgtccctg ggcctqtccc tggcgtctac 361 caccagccct tcccagctgc tggcctgcgg ccccaccgtg caccacgagt gcgggaggaa 421 catgtacctc accggactct gcttcctcct gggccccacc cagctcaccc agaggctccc 481 ggtgtccagg caggagtgcc caagacagga gcaggacatt gtgttcctga tcgatggctc 541 aggcagcatc tcctcccgca actttgccac gatgatgaac ttcgtgagag ctgtgataag 601 ccagttccag agacccagca cccagttttc cctgatgcag ttctccaaca aattccaaac 661 acacttcact ttcgaggaat tcaggcgcac gtcaaacccc ctcagcctgt tggcttctgt 721 tcaccagctg caagggttta catacacggc caccgccatc caaaatgtcg tgcaccgatt 781 gttccatgcc tcatatgggg cccgtaggga tgccaccaaa attctcattg tcatcactga 841 tgggaagaaa gaaggcgaca gcctggatta taaggatgtc atccccatgg ctgatgcagc 901 aggcatcatc cgctatgcaa ttggggttgg attagctttt caaaacagaa attcttggaa 961 agaattaaat gacattgcat cgaagccctc ccaggaacac atatttaaag tggaggactt 1021 tgatgctctg aaagatattc aaaaccaact gaaggagaag atctttgcca ttgagggtac 1081 ggagaccaca agcagtagct ccttcgaatt ggagatggca caggagggct tcagcgctgt 1141 gttcacacct gatggccccg ttctgggggc tgtggggagc ttcacctggt ctggaggtgc 1201 cttcctgtac cccccaaata tgagccctac cttcatcaac atgtctcagg agaatgtgga 1261 catgagggac tcttacctgg gttactccac cgagctggcc ctctggaaag gggtgcagag 1321 cctggtcctg ggggcccccc gctaccagca caccgggaag gctgtcatct tcacccaggt 1381 gtccaggcaa tggaggatga aggccgaagt cacgqggact cagatcggct cctacttcgg 1441 ggcctccctc tgctccgtgg acgtagacac cgacggcagc accgacctgg tcctcatcgg 1501 ggccccccat tactacgagc agacccgagg gggccaggtg tctgtgtgtc ccttgcccag 1561 ggggtggaga aggtggtggt gtgatgctgt tctctacggg gagcagggcc acccctgggg 1621 tcgctttggg gcggctctga cagtgctggg ggatgtgaat ggggacaagc tgacagacgt 1681 ggtcatcggg gccccaggag aggaggagaa ccggggtgct gtctacctgt ttcacggagt 1741 cttgggaccc agcatcagcc cctcccacag ccagcggatc gcgggctccc agctctcctc 1801 caggctgcag tattttgggc aggcactgag cgggggtcaa gacctcaccc aggatggact 1861 ggtggacctg gctgtggggg cccggggcca ggtgctcctg ctcaggacca gacctgtgct 1921 ctgggtgggg gtgagcatgc agttcatacc tgccgagatc cccaggtctg cgtttgagtg 1981 tcgggagcag gtggtctctg agcagaccct ggtacagtcc aacatctgcc tttacattga 2041 caaacgttct aagaacctgc ttgggagccg tgacctccaa agctctgtga ccttggacct 2101 ggccctcgac cctggccgcc tgagtccccg tgccaccttc caggaaacaa agaaccggag 2161 tctgagccga gtccgagtcc tcgggctgaa ggcacactgt gaaaacttca acctgctgct 2221 cccgagctgc gtggaggact ctgtgacccc cattaccttg cgtctgaact tcacgctggt 2281 gggcaagccc ctccttgcct tcagaaacct gcggcctatg ctggccgcac tggctcagag 2341 atacttcacg gcctccctac cctttgagaa gaactgtgga gccgaccata tctgccagga 2401 caatctcggc atctccttca gcttcccagg cttgaagtcc ctgctggtgg ggagtaacct 2461 ggagctgaac gcagaagtga tggtgtggaa tgacggggaa gactcctacg gaaccaccat 2521 caccttctcc caccccgcag gactgtccta ccgctacgtg gcagagggcc agaaacaagg 2581 gcagctgcgt tccctgcacc tgacatgtga cagcgcccca gttgggagcc agggcacctg 2641 gagcaccagc tgcagaatca accacctcat cttccgtggc ggcgcccaga tcaccttctt 2701 ggctaccttt gacgtctccc ccaaggctgt cctgggagac cggctgcttc tgacagccaa 2761 tgtgagcagt gagaacaaca ctcccaggac cagcaagacc accttccagc tggagctccc 2821 ggtgaagtat gctgtctaca ctgtggttag cagccacgaa caattcacca aatacctcaa 2881 cttctcagag tctgaggaga aggaaagcca tgtggccatg cacagatacc aggtcaataa 2941 cctgggacag agggacctgc ctgtcagcat caacttctgg gtgcctgtgg agctgaacca 3001 ggaggctgtg tggatggatg tggaggtcc ccacccccag aacccatccc ttcggtgctc WO 00/09525 PCTUS99/17712 EPI-109 748 3061 ctcagagaaa atcgcacccc cagcatctga cttcctggcg cacattcaga agaatcccgt 3121 gctggactgc tccattactg gctgcctgcg gttccgctgt gacgtcccct ccttcagcgt 3181 ccaggaggag ctggatttca ccctgaaggg caacctcagc tttggctggg tccgccagat 3241 attgcagaag aaggtg-zgg tcgtgagtgt ggctgaaatt acgttcgaca catccgtgta 3301 ctcccagctt ccaggacagg aggcatttat gagagctcag acgacaacgg tgctggagaa 3361 gtacaaggtc cacaacccca cccccctcat cgtaggcagc tccattgggg gtctgttgct 3421 gctggcactc atcacagcgg tactgtacaa agttggcttc ttcaagcgtc agtacaagga 3481 aatgatggag gaggcaaatg gacaaattgc cccagaaaac gggacacaga cccccagccc 3541 gcccagtgag aaatgatccc tctttgcctt ggacttcttc tcccgcgatt ttccccactt 3601 acttaccctc acctgtcagg ctgacgggga ggaaccactg caccaccgag agaggctggg 3661 atgggcctgc ttcctgtctt tgggagaaaa cgtcttgctt gggaaggggc ctttgtcttg 3721 tcaaggttcc aactggaaac ccttaggaca gggtccctgc tgtgttcccc aaaaggactt 3781 gacttgcaat ttctacctag aaatacatgg acaatacccc caggcctcag tctcccttct 3841 cccatgaggc acgaatgatc tttctttcct ttcctttttt ttttttttct tttctttttt 3901 tttttttttg agacggagtc tcgctctgtc acccaggctg gagtgcaatg gcgtgatctc 3961 ggctcgctgc aacctccgcc tcccgggttc aagtaattct gctgtctcag cctcctgcgt 4021 agctgggact acaggcacac gccacctcgc ccggcccgat ctttctaaaa tacagttctg 4081 aatatgctgc tcatccccac ctgtcttcaa cagctcccca ttaccctcag gacaatgtct 4141 gaactctcca gcttcgcgtg agaagtcccc ttccatccca gagggtgggc ttcagggcgc 4201 acagcatgag agcctctgtg cccccatcac cctcgtttcc agtgaattag tgtcatgtca 4261 gcatcagctc agggcttcat cgtggggctc tcagttccga ttccccaggc tgaattggga 4321 gtgagatgcc tgcatgctgg gttctgcaca gctggcctcc cgcggttggg tcaacattgc 4381 tggcctggaa gggaggagcg ccctctaggg agggacatgg ccccggtgcg gctgcagctc 4441 accagcccca ggggcagaag agacccaacc acttcctatt ttttgaggct atgaatatag 4501 tacctgaaaa aatgccaagc actagattat ttttttaaaa agcgtacttt aaatgtttgt 4561 gttaatacac attaaaacat cgcacaaaaa cgatgcatct accgctcctt gggaaataat 4621 ctgaaaggtc taaaaataaa aaagccttct gtggaaaaaa aaaaaaaaaa aaaaaaaaaa 4681 aaaaaaaaaa aaaaaaaaaa aaaa (2) INFORMATION FOR SEQ ID NO:2573: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 4621 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2573: 1 gaattcctgc cactcttcct gcaacggccc aggagctcag agctccacat ctgaccttct 61 agtcatgacc aggaccaggg cagcactcct cctgttcaca gccttagcaa cttctctagg 121 tttcaacttg gacacagagg agctgacagc cttccgtgtg gacagcgctg ggtttggaga 181 cagcgtggtc cagtatgcca actcctgggt ggtggttgga gccccccaaa agataacagc 241 tgccaaccaa acgggtggcc tctaccagtg tggctacagc actggtgcct gtgagcccat 301 cggcctgcag gtgcccccgg aggccgtgaa catgtccctg ggcctgtccc tggcgtctac 361 caccagccct tcccagcrgc tggcctgcgg ccccaccgtg caccacgagt gcgggaggaa 421 catgtacctc accggactct gcttcctcct gggccccacc cagctcaccc agaggctccc 481 ggtgtccagg caggagtgcc caagacagga gcaggacatt gtgttcctga tcgatggctc 541 aggcagcatc tcctcccgca actttgccac gatgatgaac ttcgtgagag ctgtgataag 601 ccagttccag agacccagca cccagttttc cctgatgcag ttctccaaca aattccaaac 661 acacttcact ttcgaggaat tcaggcgcac gtcaaacccc ctcagcctgt tggcttctgt 721 tcaccagctg caagggttta catacacggc caccgccatc caaaatgtcg tgcaccgatt 781 gttccatgcc tcatatgggg cccgtaggga tgccaccaaa attctcattg tcatcactga 841 tgggaagaaa gaaggcgaca gcctggatta taaggatgtc atccccatgg ctgatgcagc 901 aggcatcatc cgcagcaa ttggggttgg attagctttt caaaacagaa attcttggaa 961 agaattaaat gacattgcat cgaagccctc ccaggaacac atatttaaag tggaggactt 1021 tgatgctctg aaagatattc aaaaccaact gaaggagaag atctttgcca ttgagggtac 1081 ggagaccaca agcagtagct ccttcgaatt ggagatggca caggagggct tcagcgctgt 1141 gttcacacct gatggccccg ttctgggggc tgtggggagc ttcacctggt ctggaggtgc 1201 cttcctgtac cccccaaaca tgagccctac cttcatcaac atgtctcagg agaatgtgga 1261 catgagggac tcttacctgg gttactccac cgagctggcc ctctggaaag gggtgcagag 1321 cctggtcctg ggggcccccc gctaccagca caccgggaag gctgtcatct tcacccaggt 1381 gtccaggcaa tggaggatta aggccgaagt cacggggact cagatcggct cctacttcgg 1441 ggcctccctc tgctccgtgg acgtagacac cgacggcagc accgacctgg tcctcatcgg 1501 ggccccccat tactacgagc agacccgagg gggccaggtg tctgtgtgtc ccttgcccag 1561 ggggtggaga aggtggtggt gtgatgctgt tctctacggg gagcagggcc acccctgggg 1621 tcgctttggg gcggctctga cagtgctggg ggatgtgaat ggggacaagc tgacagacgt 1681 ggtcatcggg gccccaggag aggaggagaa ccggggtgct gtctacctgt ttcacggagt 1741 cttgggaccc agcatcagcc cctcccacag ccagcggatc gcgggctccc agctctcctc 1801 caggctgcag tattttgggc aggcactgag cgggggtcaa gacctcaccc aggatggact 1861 ggtggacctg gctgtggggg cccggggcca ggtgctcctg ctcaggacca gacctgtgct 1921 ctgggtgggg gtgagcatac agttcatacc tgccgagatc cccaggtctg cgtttgagtg WO 00/09525 PCT/US99/17712 EPI-109 749 1981 tcgggagcag gtggtctctg agcagaccct ggtacagtcc aacatctgcc tttacattga 2041 caaacgttct aagaacctgc ttgggagccg tgacctccaa agctctutga ccttggacct 2101 ggccctcgac cctggccgcc tgagtccccg tgccaccttc caggaaacaa agaaccggag 2161 tctgagccga gtccgagtcc tcgggctgaa ggcacactgt gaaaacttca acctgctgct 2221 cccgagctgc gtggaggact ctgtgacccc cattaccttg cgtctqaact tcacgctggt 2281 gggcaagccc ctccttgcct tcagaaacct gcggcctatg ctggccgcac tggctcagag 2341 atacttcacg gcctccctac cctttgagaa gaactgtgga gccgaccata tctgccagga 2401 caatctcggc atctccttca gcttcccagg cttgaagtcc ctgctggtgg ggagtaacct 2461 ggagctgaac gcagaagtga tggtgtggaa tgacggggaa gactcctacg gaaccaccat 2521 caccttctcc caccccgcaq gactgtccta ccgctacgtg gcagagggcc agaaacaagg 2581 gcagctgcgt tccctgcacc tgacatgtga cagcgcccca gttgggagcc agggcacctg 2641 gagcaccagc tgcagaatca accacctcat cttccgtggc ggcgcccaga tcaccttctt 2701 ggctaccttt gacgtctccc ccaaggctgt cctgggagac cggctgcttc tgacagccaa 2761 tgtgagcagt gagaacaaca ctcccaggac cagcaagacc accttccagc tggagctccc 2821 ggtgaagtat gctgtctaca ctgtggttag cagccacgaa caattcacca aatacctcaa 2881 cttctcagag tctgaggaga aggaaagcca tgtggccatg cacagatacc aggtcaataa 2941 cctgggacag agggacctgc ctgtcagcat caacttctgg gtgcctgtgg agctgaacca 3001 ggaggctgtg tggatggatg tggaggtctc ccacccccag aacccatccc ttcggtgctc 3061 ctcagagaaa atcgcacccc cagcatctga cttcctggcg cacattcaga agaatcccgt 3121 gctggactgc tccattgctg gctgcctgcg gttccgctgt gacgtcccct ccttcagcgt 3181 ccaggaggag ctggatttca ccctgaaggg caacctcagc tttggctggg tccgccagat 3241 attgcagaag aaggtgtcgg tcgtgagtgt ggctgaaatt acgttcgaca catccgtgta 3301 ctcccagctt ccaggacagg aggcatttat gagagctcag acgacaacgg tgctggagaa 3361 gtacaaggtc cacaacccca cccccctcat cgtaggcagc tccattgggg gtctgttgct 3421 gctggcactc atcacagcgg tactgtacaa agttggcttc ttcaagcgtc agtacaagga 3481 aatgatggag gaggcaaatg gacaaattgc cccagaaaac gggacacaga cccccagccc 3541 gcccagtgag aaatgatccc tctttgcctt ggacttcttc tcccgcgatt ttccccactt 3601 acttaccctc acctgtcagg ctgacgggga ggaaccactg caccaccgag agaggctggg 3661 atgggcctgc ttcctgtctt tgggagaaaa cgtcttgctt gggaaggggc ctttgtcttg 3721 tcaaggttcc aactggaaac ccttaggaca gggtccctgc tgtgttcccc aaaaggactt 3781 gacttgcaat ttctacctag aaatacatgg acaatacccc caggcctcag tctcccttct 3841 cccatgaggc acgaatgatc tttctttcct ttcctttttt ttttttttct tttctttttt 3901 tttttttttg agacggagtc tcgctctgtc acccaggctg gagtgcaatg gcgtgatctc 3961 ggctcgctgc aacctccgcc tcccgggttc aagtaattct gctgtctcag cctcctgcgt 4021 agctgggact acaggcacac gccacctcgc ccggcccgat ctttctaaaa tacagttctg 4081 aatatgctgc tcatccccac ctgtcttcaa cagctcccca ttaccctcag gacaatgtct 4141 gaactctcca gcttcgcgtg agaagtcccc ttccatccca gagggtgggc ttcagggcgc 4201 acagcatgag agcctctgtg cccccatcac cctcgtttcc agtgaattag tgtcatgtca 4261 gcatcagctc agggcttcat cgtggggctc tcagttccga ttccccaggc tgaattggga 4321 gtgagatgcc tgcatgctgg gttctgcaca gctggcctcc cgcggttggg tcaacattgc 4381 tggcctggaa gggaggagcg ccctctaggg agggacatgg ccccggtgcg gctgcagctc 4441 accagcccca ggggcagaag agacccaacc acttcctatt ttttgaggct atgaatatag 4501 tacctgaaaa aatgccaagc actagattat ttttttaaaa agcgtacttt aaatgtttgt 4561 gttaatacac attaaaacat cgcacaaaaa cgatgcatct accgctcctt gggaaataat 4621 ctgaaaggtc taaaaataaa aaagccttct gtgg (2) INFORMATION FOR SEQ ID NO:2574: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 2281 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2574: 1 ctcgccctgg tggggctgct ctccctcggg tgcgtcctct ctcaggagtg cacgaagttc 61 aaggtcagca gctgccggga atgcatcgag tcggggcccg gctgcacctg gtgccagaag 121 ctgaacttca cagggccggg ggatcctgac tccattcgct gcgacacccg gccacagctg 181 ctcatgaggg gctgtgcggc tgacgacatc atggacccca caagcctcgc tgaaacccag 241 gaagaccaca atgggggcca gaagcagctg tccccacaaa aagtgacgct ttacctgcga 301 ccaggccagg cagcagcgtt caacgtgacc ttccggcggg ccaagggcta ccccatcgac 361 ctgtactatc tgatggacct ctcctactcc atgcttgatg acctcaggaa tgtcaagaag 421 ctaggtggcg acctgctccg ggccctcaac gagatcaccg agtccggccg cattggcttc 481 gggtccttcg tggacaagac cgtgctgccg ttcgtgaaca cgcaccctga taagctgcga 541 aacccatgcc ccaacaagga gaaagagtgc ccgcccccgt ttgccttcag gcacgtgctg 601 aagctgacca acaactccaa ccagtttcag accgaggtcg ggaagcagct gatttccgga 661 aacctggatg cacccgaggg tgggctggac gccatgatgc aggtcgccgc ctgcccggag 721 gaaatcggct ggcgcaacgt cacgcggctg ctggtgtttg ccactgatga cggcttccat 781 ttcgcgggcg acggaaagct gggcgccatc ctgaccccca acgacggccg ctgtcacctg 841 gaggacaact tatacaagag gagcaacgaa ttcgactacc catcggtggg ccagctggcg 901 cacaagctgg ctgaaaacaa catccagccc atcttcgcgg tgaccagtag gatggtgaag WO 00/09525 PCT/US99/17712 EPI-109 750 961 acctacgaga aactcaccga gatcatcccc aagtcagccg tgggggagct gtctgaggac 1021 tccagcaatg tggtccatct cattaagaat gcttacaata aactctcrtc cagggtcttc 1081 ctggatcaca acgccctccc cgacaccctg aaagtcacct acgactcctt ctgcagcaat 1141 ggagtgacgc acaggaacca gcccagaggt gactgtgatg gcgtgcagat caatgtcccg 1201 atcaccttcc aggtgaaggt cacggccaca gagtgcatcc aggagcagtc gtttgtcatc 1261 cgggcgctgg gcttcacgga catagtgacc gtgcaggtcc ttccccagtg tgagtgccgg 1321 tgccgggacc agagcagaga ccgcagcctc tgccatggca agggctt-ctt ggagtgcggc 1381 atctgcaggt gtgacactgg ctacattggg aaaaactgtg agtgccagac acagggccgg 1441 agcagccagg agctggaagg aagctgccgg aaggacaaca actccatcat ctgctcaggg 1501 ctgggggact gtgtctgcgg gcagtgcctg tgccacacca gcgacgzccc cggcaagctg 1561 atatacgggc agtactgcqa gtgtgacacc atcaactgtg agcgctacaa cggccaggtc 1621 tgcggcggcc cggggagggg gctctgcttc tgcgggaagt gccgctacca cccgggcttt 1681 gagggctcag cgtgccagtg cgagaggacc actgagggct gcctgaaccc gcggcgtgtt 1741 gagtgtagtg gtcgtggccg gtgccgctgc aacgtatgcg agtgccattc aggctaccag 1801 ctgcctctgt gccaggagtg ccccggctgc ccctcaccct gtggcaagta catctcctgc 1861 gccgagtgcc tgaagttcga aaagggcccc tttgggaaga actgcaacgc ggcgtgtccg 1921 ggcctgcagc tgtcgaacaa ccccgtgaag ggcaggacct gcaaggagag ggactcagag 1981 ggctgctggg tggcctacac gctggagcag caggacggga tggaccgcta cctcatctat 2041 gtggatgaga gccgagagtg tgtggcaggc cccaacatcg ccgccatcgt cgggggcacc 2101 gtggcaggca tcgtgctgat cggcattctc ctgctggtca tctggaaggc tctgatccac 2161 ctgagcgacc tccgggagta caggcgcttt gagaaggaga agctcaagtc ccagtggaac 2221 aatgataatc cccttttcaa gagcgccacc acgacggtca tgaaccccaa gtttgctgag 2281 agttaggagc a (2) INFORMATION FOR SEQ ID NO:2575: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 11583 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2575: 1 gaattcctgc cactcttcct gcaacggccc aggagctcag agctccacat ctgaccttct 61 agtcatgacc aggaccaggg cagcactcct cctgttcaca gccttagcaa cttctctagg 121 tttcaacttg gacacagagg agctgacagc cttccgtgtg gacagcgctg ggtttggaga 181 cagcgtggtc cagiatgcca actcctgggt ggtggttgga gccccccaaa agataacagc 241 tgccaaccaa acgggtggcc tctaccagtg tggctacagc actggtgcct gtgagcccat 301 cggcctgcag gtgcccccgg aggccgtgaa catgtccctg ggcctgtccc tggcgtctac 361 caccagccct tcccagctgc tggcctgcgg ccccaccgtg caccacgagt gcgggaggaa 421 catgtacctc accggactct gcttcctcct gggccccacc cagctcaccc agaggctccc 481 ggtgtccagg caggagtgcc caagacagga gcaggacatt gtgttcctga tcgatggctc 541 aggcagcatc tcctcccgca actttgccac gatgatgaac ttcgtgagag ctgtgataag 601 ccagttccag agacccagca cccagttttc cctgatgcag ttctccaaca aattccaaac 661 acacttcact ttcgaggaat tcaggcgcac gtcaaacccc ctcagcctgt tggcttctgt 721 tcaccagctg caagggttta catacacggc caccgccatc caaaatgtcg tgcaccgatt 781 gttccatgcc tcatatgggg cccgtaggga tgccaccaaa attctcattg tcatcactga 841 tgggaagaaa gaaggcgaca gcctggatta taaggatgtc atccccatgg ctgatgcagc 901 aggcatcatc cgctatgcaa ttggggttgg attagctttt caaaacagaa attcttggaa 961 agaattaaat gacattgcat cgaagccctc ccaggaacac atatttaaag tggaggactt 1021 tgatgctctg aaagatattc aaaaccaact gaaggagaag atctttgcca ttgagggtac 1081 ggagaccaca agcagtagct ccttcgaatt ggagatggca caggagggct tcagcgctgt 1141 gttcacacct gatggccccg ttctgggggc tgtggggagc ttcacctggt ctggaggtgc 1201 cttcctgtac cccccaaata tgagccctac cttcatcaac atgtctcagg agaatgtgga 1261 catgagggac tcttacctgg gttactccac cgagctggcc ctctggaaag gggtgcagag 1321 cctggtcctg ggggcccccc gctaccagca caccgggaag gctgtcatct tcacccaggt 1381 gtccaggcaa tggaggatga aggccgaagt cacggggact cagatcggct cctacttcgg 1441 ggcctccctc tgctccgtgg acgtagacac cgacggcagc accgacctgg tcctcatcgg 1501 ggccccccat tactacgagc agacccgagg gggccaggtg tctgtgtgtc ccttgcccag 1561 ggggtggaga aggtggtggt gtgatgctgt tctctacggg gagcagggcc acccctgggg 1621 tcgctttggg gcggctctga cagtgctggg ggatgtgaat ggggacaagc tgacagacgt 1681ggtcatcggg gccccaggag aggaggagaa ccggggtgct gtctacctgt ttcacggagt 1741 cttgggaccc agcatcagcc cctcccacag ccagcggatc gcgggctccc agctctcctc 1801 caggctgcag tattttgggc aggcactgag cgggggtcaa gacctcaccc aggatggact 1861 ggtggacctg gctgtggggg cccggggcca ggtgctcctg ctcaggacca gacctgtgct 1921 ctgggtgggg gtgagcatgc agttcatacc tgccgagatc cccaggtctg cgtttgagtg 1981 tcgggagcag gtggtctctg agcagaccct ggtacagtcc aacatctgcc tttacattga 2041 caaacgttct aagaacctgc ttgggagccg tgacctccaa agctctgtga ccttggacct 2101 ggccctcgac cctggccgcc tgagtccccg tgccaccttc caggaaacaa agaaccggag 2161 tctgagccga gtccgagtcc tcgggctgaa ggcacactgt gaaaacttca acctgctgct 2221 cccgagctgc gtggaggact ctgtgacccc cattaccttg cgtctgaact tcacgctggt WO 00/09525 PCTUS99/17712 EPI-109 751 2281 gggcaagccc ctccttgcct tcagaaacct gcggcctatg ctggccgcac tggctcagag 2341 atacttcacg gcctccctac cctttgagaa gaactgtgga gccgaccata tctgccagga 2401 caatctcggc atctccttca gcttcccagg cttgaagtcc ctgctggtgg ggagtaacct 2461 ggagctgaac gcagaagtga tggtgtggaa tgacggggaa gactcctacg gaaccaccat 2521 caccttctcc caccccgcag gactgtccta ccgctacgtg gcagagggcc agaaacaagg 2581 gcagctgcgt tccctgcacc tgacatgtga cagcgcccca gttgggagcc agggcacctg 2641 gagcaccagc tgcagaatca accacctcat cttccgtggc ggcgcccaga tcaccttctt 2701 ggctaccttt gacgtctccc ccaaggctgt cctgggagac cggctgcttc tgacagccaa 2761 tgtgagcagt gagaacaaca ctcccaggac cagcaagacc accttccagc tggagctccc 2821 ggtgaagtat gctgtctaca ctgtggttag cagccacgaa caattcacca aatacctcaa 2881 cttctcagag tctgaggaga aggaaagcca tgtggccatg cacagatacc aggtcaataa 2941 cctgggacag agggacctgc ctgtcagcat caacttctgg gtgcctgtgg agctgaacca 3001 ggaggctgtg tggatggatg tggaggtctc ccacccccag aacccatccc ttcggtgctc 3061 ctcagagaaa atcgcacccc cagcatctga cttcctggcg cacattcaga agaatcccgt 3121 gctggactgc tccattgctg gctgcctgcg gttccgctgt gacgtcccct ccttcagcgt 3181 ccaggaggag ctggatttca ccctgaaggg caacctcagc tttggctggg tccgccagat 3241 attgcagaag aaggtgtcgg tcgtgagtgt ggctgaaatt acgttcgaca catccgtgta 3301 ctcccagctt ccaggacagg aggcatttat gagagctcag acgacaacgg tgctggagaa 3361 gtacaaggtc cacaacccca cccccctcat cgtaggcagc tccattgggg gtctgttgct 3421 gctggcactc atcacagcgg tactgtacaa agttggcttc ttcaagcgtc agtacaagga 3481 aatgatggag gaggcaaatg gacaaattgc cccagaaaac gggacacaga cccccagccc 3541 gcccagtgag aaatgatccc tctttgcctt ggacttcttc tcccgcgatt ttccccactt 3601 acttaccctc acctgtcagg ctgacgggga ggaaccactg caccaccgag agaggctggg 3661 atgggcctgc ttcctgtctt tgggagaaaa cgtcttgctt gggaaggggc ctttgtcttg 3721 tcaaggttcc aactggaaac ccttaggaca gggtccctgc tgtgttcccc aaaaggactt 3781 gacttgcaat ttctacctag aaatacatgg acaatacccc caggcctcag tctcccttct 3841 cccatgaggc acgaatgatc tttctttcct ttcctttttt ttttttttct tttctttttt 3901 tttttttttg agacggagtc tcgctctgtc acccaggctg gagtgcaatg gcgtgatctc 3961 ggctcgctgc aacctccgcc tcccgggttc aagtaattct gctgtctcag cctcctgcgt 4021 agctgggact acaggcacac gccacctcgc ccggcccgat ctttctaaaa tacagttctg 4081 aatatgctgc tcatccccac ctgtcttcaa cagctcccca ttaccctcag gacaatgtct 4141 gaactctcca gcttcgcgtg agaagtcccc ttccatccca gagggtgggc ttcagggcgc 4201 acagcatgag agcctctgtg cccccatcac cctcgtttcc agtgaattag tgtcatgtca 4261 gcatcagctc agggcttcat cgtggggctc tcagttccga ttccccaggc tgaattggga 4321 gtgagatgcc tgcatgctgg gttctgcaca gctggcctcc cgcggttggg tcaacattgc 4381 tggcctggaa gggaggagcg ccctctaggg agggacatgg ccccggrgcg gctgcagctc 4441 accagcccca ggggcagaag agacccaacc acttcctatt ttttgaggct atgaatatag 4501 tacctgaaaa aatgccaagc actagattat ttttttaaaa agcgtacttt aaatgtttgt 4561 gttaatacac attaaaacat cgcacaaaaa cgatgcatct accgctcctt gggaaataat 4621 ctgaaaggtc taaaaataaa aaagccttct gtggaaaaaa aaaaaaaaaa aaaaaaaaaa 4681 aaaaaaaaaa aaaaaaaaaa aaaa 1 gaattcctgc cactcttcct gcaacggccc aggagctcag agctccacat ctgaccttct 61 agtcatgacc aggaccaggg cagcactcct cctgttcaca gccttagcaa cttctctagg 121 tttcaacttg gacacagagg agctgacagc cttccgtgtg gacagcgctg ggtttggaga 181 cagcgtggtc cagtatgcca actcctgggt ggtggttgga gccccccaaa agataacagc 241 tgccaaccaa acgggtggcc tctaccagtg tggctacagc actggtgcct gtgagcccat 301 cggcctgcag gtgcccccgg aggccgtgaa catgtccctg ggcctgtccc tggcgtctac 361 caccagccct tcccagctgc tggcctgcgg ccccaccgtg caccacgagt gcgggaggaa 421 catgtacctc accggactct gcttcctcct gggccccacc cagctcaccc agaggctccc 481 ggtgtccagg caggagtgcc caagacagga gcaggacatt gtgttcctga tcgatggctc 541 aggcagcatc tcctcccgca actttgccac gatgatgaac ttcgtgagag ctgtgataag 601 ccagttccag agacccagca cccagttttc cctgatgcag ttctccaaca aattccaaac 661 acacttcact ttcgaggaat tcaggcgcac gtcaaacccc ctcagcctgt tggcttctgt 721 tcaccagctg caagggttta catacacggc caccgccatc caaaatgtcg tgcaccgatt 781 gttccatgcc tcatatgggg cccgtaggga tgccaccaaa attctcattg tcatcactga 841 tgggaagaaa gaaggcgaca gcctggatta taaggatgtc atccccatgg ctgatgcagc 901 aggcatcatc cgctatgcaa ttggggttgg attagctttt caaaacagaa attcttggaa 961 agaattaaat gacattgcat cgaagccctc ccaggaacac atatttaaag tggaggactt 1021 tgatgctctg aaagatattc aaaaccaact gaaggagaag atctttgcca ttgagggtac 1081'ggagaccaca agcagtagct ccttcgaatt ggagatggca caggagggct tcagcgctgt 1141 gttcacacct gatggccccg ttctgggggc tgtggggagc ttcaccagt ctggaggtgc 1201 cttcctgtac cccccaaata tgagccctac cttcatcaac atgtctcagg agaatgtgga 1261 catgagggac tcttacctgg gttactccac cgagctggcc ctctggaaag gggtgcagag 1321 cctggtcctg ggggcccccc gctaccagca caccgggaag gctgtcatct tcacccaggt 1381 gtccaggcaa tggaggatga aggccgaagt cacggggact cagatcggct cctacttcgg 1441 ggcctccctc tgctccgtgg acgtagacac cgacggcagc accgacctgg tcctcatcgg 1501 ggccccccat tactacgagc agacccgagg gggccaggtg tctgtgtgtc ccttgcccag 1561 ggggtggaga aggtggtggt gtgatgctgt tctctacggg gagcagggcc acccctgggg WO 00/09525 PCT/US99/17712 EPI-109 752 1621 tcgctttggg gcggctc:ga cagtgctggg ggatgtgaat ggggacaagc tgacagacgt 1681 ggtcatcggg gccccaaaag aggaggagaa ccggggtgct gtctacctgt ttcacggagt 1741 cttgggaccc agcatcaacc cctcccacag ccagcggatc gcgggctccc agctctcctc 1801 caggctgcag tattttuggc aggcactgag cgggggtcaa gacctcaccc aggatggact 1861 ggtggacctg gctgtgggg cccggggcca ggtgctcctg ctcaggacca gacctgtgct 1921 ctgggtgggg gtgaqcalgc agttcatacc tgccgagatc cccaggtctg cgtttgagtg 1981 tcgggagcag gtggtctctg agcagaccct qgtacagtcc aacatctgcc tttacattga 2041 caaacgttct aagaacczc ttgggagccg tgacctccaa agctctgtga ccttggacct 2101 ggccctcgac cctggccucc tgagtccccg tgccaccttc caggaaacaa agaaccggag 2161 tctgagccga gtccgagtcc tcgggctgaa ggcacactgt gaaaacttca acctgctgct 2221 cccgagctgc gtggaggact ctgtgacccc cattaccttg cgtctgaact tcacgctggt 2281 gggcaagccc ctccttaoct tcagaaacct gcggcctatg ctggccgcac tggctcagag 2341 atacttcacg gcctccczac cctttgagaa gaactgtgga gccgaccata tctgccagga 2401 caatctcggc atctc:ca gcttcccagg cttgaagtcc ctgctggtgg ggagtaacct 2461 ggagctgaac gcagaagcga tggtgtggaa tgacggggaa gactcctacg gaaccaccat 2521 caccttctcc caccccacag gactgtccta ccgctacgtg gcagagggcc agaaacaagg 2581 gcagctgcgt tccctgcacc tgacatgtga cagcgcccca gttgggagcc agggcacctg 2641 gagcaccagc tgcagaatca accacctcat cttccgtggc ggcgcccaga tcaccttctt 2701 ggctaccttt gacgtctccc ccaaggctgt cctgggagac cggctgcttc tgacagccaa 2761 tgtgagcagt gagaacaaca ctcccaggac cagcaagacc accttccagc tggagctccc 2821 ggtgaagtat gctgtctaca ctgtggttag cagccacgaa caattcacca aatacctcaa 2881 cttctcagag tctgaggaga aggaaagcca tgtggccatg cacagatacc aggtcaataa 2941 cctgggacag agggacczgc ctgtcagcat caacttctgg gtgcctgtgg agctgaacca 3001 ggaggctgtg tggatggatg tggaggtctc ccacccccag aacccatccc ttcggtgctc 3061 ctcagagaaa atcgcacccc cagcatctga cttcctggcg cacattcaga agaatcccgt 3121 gctggactgc tccattgctg gctgcctgcg gttccgctgt gacgtcccct ccttcaqcgt 3181 ccaggaggag ctggatttca ccctgaaggg caacctcagc tttggctggg tccgccagat 3241 attgcagaag aaggtgtcgg tcgtgagtgt ggctgaaatt acgttcgaca catccgtgta 3301 ctcccagctt ccaggacagg aggcatttat gagagctcag acgacaacgg tgctggagaa 3361 gtacaaggtc cacaacccca cccccctcat cgtaggcagc tccattgggg gtctgttgct 3421 gctggcactc atcacagcgg tactgtacaa agttggcttc ttcaagcgtc agtacaagga 3481 aatgatggag gaggcaaatg gacaaattgc cccagaaaac gggacacaga cccccagccc 3541 gcccagtgag aaatgatccc tctttgcctt ggacttcttc tcccgcgatt ttccccactt 3601 acttaccctc acctgtcagg ctgacgggga ggaaccactg caccaccgag agaggctggg 3661 atgggcctgc ttcctgtctt tgggagaaaa cgtcttgctt gggaaggggc ctttgtcttg 3721 tcaaggttcc aactggaaac ccttaggaca gggtccctgc tgtgttcccc aaaaggactt 3781 gacttgcaat ttctacctag aaatacatgg acaatacccc caggcctcag tctcccttct 3841 cccatgaggc acgaatgatc tttctttcct ttcctttttt ttttttttct tttctttttt 3901 tttttttttg agacggagtc tcgctctgtc acccaggctg gagtgcaatg gcgtgatctc 3961 ggctcgctgc aacctccgcc tcccgggttc aagtaattct gctgtctcag cctcctgcgt 4021 agctgggact acaggcacac gccacctcgc ccggcccgat ctttctaaaa tacagttctg 4081 aatatgctgc tcatccccac ctgtcttcaa cagctcccca ttaccctcag gacaatgtct 4141 gaactctcca gcttcgcgtg agaagtcccc ttccatccca gagggtgggc ttcagggcgc 4201 acagcatgag agcctctgtg cccccatcac cctcgtttcc agtgaattag tgtcatgtca 4261 gcatcagctc agggcttcat cgtggggctc tcagttccga ttccccaggc tgaattggga 4321 gtgagatgcc tgcatgctgg gttctgcaca gctggcctcc cgcggttggg tcaacattgc 4381 tggcctggaa gggaggagcg ccctctaggg agggacatgg ccccggtgcg gctgcagctc 4441 accagcccca ggggcagaag agacccaacc acttcctatt ttttgaggct atgaatatag 4501 tacctgaaaa aatgccaagc actagattat ttttttaaaa agcgtacttt aaatgtttgt 4561 gttaatacac attaaaacat cgcacaaaaa cgatgcatct accgctcctt gggaaataat 4621 ctgaaaggtc taaaaataaa aaagccttct gtgg 1 ctcgccctgg tggggctgct ctccctcggg tgcgtcctct ctcaggagtg cacgaagttc 61 aaggtcagca gctgccggga atgcatcgag tcggggcccg gctgcacctg gtgccagaag 121 ctgaacttca cagggccggg ggatcctgac tccattcgct gcgacacccg gccacagctg 181 ctcatgaggg gctgtgcggc tgacgacatc atggacccca caagcctcgc tgaaacccag 241 gaagaccaca atgggggcca gaagcagctg tccccacaaa aagtgacgct ttacctgcga 301 ccaggccagg cagcagcgtt caacgtgacc ttccggcggg ccaagggcta ccccatcgac 361 ctgtactatc tgatggacct ctcctactcc atgcttgatg acctcaggaa tgtcaagaag 421 ctaggtggcg acctgctccg ggccctcaac gagatcaccg agtccggccg cattggcttc 481 gggtccttcg tggacaagac cgtgctgccg ttcgtgaaca cgcaccctga taagctgcga 541 aacccatgcc ccaacaagga gaaagagtgc ccgcccccgt ttgccttcag gcacgtgctg 601 aagctgacca acaactccaa ccagtttcag accgaggtcg ggaagcagct gatttccgga 661 aacctggatg cacccgaggg tgggctggac gccatgatgc aggtcgccgc ctgcccggag 721 gaaatcggct ggcgcaacgt cacgcggctg ctggtgtttg ccactgatga cggcttccat 781 ttcgcgggcg acggaaagct gggcgccatc ctgaccccca acgacggccg ctgtcacctg 841 gaggacaact tgtacaagag gagcaacgaa ttcgactacc catcggtggg ccagctggcg 901 cacaagctgg ctgaaaacaa catccagccc atcttcgcgg tgaccagtag gatggtgaag 961 acctacgaga aactcaccga gatcatcccc aagtcagccg tgggggagct gtctgaggac WO 00/09525 PCT/US99/17712 EPI-109 753 1021 tccagcaatg tggtccatct cattaagaat gcttacaata aactctcctc cagggtcttc 1081 ctggatcaca acgccctccc cgacaccctg aaagtcacct acgactcctt ctgcagcaat 1141 ggagtgacgc acaggaacca gcccagaggt gactgtgatg gcgtgcagat caatgtcccg 1201 atcaccttcc aggtgaaggt cacggccaca gagtgcatcc aggagcagtc gtttgtcatc 1261 cgggcgctgg gcttcacgga catagtgacc gtgcaggtcc ttccccagtg tgagtgccgg 1321 tgccgggacc agagcagaga ccgcagcctc tgccatggca agggcttctt ggagtgcggc 1381 atctgcaggt gtgacactgg ctacattggg aaaaactgtg agtgccagac acagggccgg 1441 agcagccagg agctggaagg aagctgccgg aaggacaaca actccatcat ctgctcaggg 1501 ctgggggact gtgtctgcgg gcagtgcctg tgccacacca gcgacgtccc cggcaagctg 1561 atatacgggc agtactgcga gtgtgacacc atcaactgtg agcgctacaa cggccaggtc 1621 tgcggcggcc cggggagggg gctctgcttc tgcgggaagt gccgctgcca cccgggcttt 1681 gagggctcag cgtgccagtg cgagaggacc actgagggct gcctgaaccc gcggcgtgtt 1741 gagtgtagtg gtcgtggccg gtgccgctgc aacgtatgcg agtgccattc aggctaccag 1801 ctgcctctgt gccaggagtg ccccggctgc ccctcaccct gtggcaagta catctcctgc 1861 gccgagtgcc tgaagttcga aaagggcccc tttgggaaga actgcagcgc ggcgtgtccg 1921 ggcctgcagc tgtcgaacaa ccccgtgaag ggcaggacct gcaaggagag ggactcagag 1981 ggctgctggg tggcctacac gctggagcag caggacggga tggaccgcta cctcatctat 2041 gtggatgaga gccgagagtg tgtggcaggc cccaacatcg ccgccatcgt cgggggcacc 2101 gtggcaggca tcgtgctgat cggcattctc ctgctggtca tctggaaggc tctgatccac 2161 ctgagcgacc tccgggagta caggcgcttt gagaaggaga agctcaagtc ccagtggaac 2221 aatgataatc cccttttcaa gagcgccacc acgacggtca tgaaccccaa gtttgctgag 2281 agttaggagc a (2) INFORMATION FOR SEQ ID NO:2576: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 661 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2576: 1 tcttcctctc ctgggccgtc ctctgagcag cagacggggc taagcgttcc ccagctcgcc 61 ttcacacaca gcccgtgcca ccacaccgac ggtaccatga aggacgaggt agctctactg 121 gctgctgtca ccctcctggg agtcctgctg caagcctact tctccctgca ggtgatctcg 181 gcgcgcaggg ccttccgcgt gtcgccgccg ctcaccaccg gcccacccga gttcgagcgc 241 gtctaccgag cccaggtgaa ctgcagcgag tacttcccgc tgttcctcgc cacgctctgg 301 gtcgccggca tcttctttca tgaaggggcg gcggccctgt gcggcctggt ctacctgttc 361 gcgcgcctcc gctacttcca gggctacgcg cgctccgcgc agctcaggct ggcaccgctg 421 tacgcgagcg cgcgcgccct ctggctgctg gtggcgctgg ctgcgctcgg cctgctcgcc 481 cacttcctcc cggccgcgct gcgcgccgcg ctcctcggac ggctccggac gctgctgccg 541 tgggcctgag accaaggccc ccgggccgac ggagccggga aagaagagcc ggagcctcca 601 gctgccccgg ggaggggcgc tcgcttccgc atcctagtct ctatcattaa agttctagtg 661 accga (2) INFORMATION FOR SEQ ID NO:2577: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 4441 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2577: 1 gagctcacag agcccccagc tggggcatat ctggtttccg ggggcagggg cgatacccag 61 aggaggaaga agggattctg agagagccca acaggctccg agcctcaggc tggagctgag 121 cttggggcag caaggaagga ccaggtgcga gggcagaacc atgcggcccg acccctgcag 181 cacggcctgt ggcctccccc agctcctgcc cgtgcttctg ggtcagtctg gactttgcca 241 cttctgacca aaagccaccg caaacccact caagccaaaa gaggaagtga ccgttaggcc 301 caactgggaa ggctggcggc caggggcact ccaggcaggg cgaggggggc ggccgggggc 361 gctccaggcg gggcgaggga gacacccaga actccaggca ggagtcctcg ggtgccacct 421 ttcctctcca cctggccctg cgtgggctct gtcctcaggg tggcccgccg tagtccccct 481 ccccactctg agtttcctgt cccaaagtcc taaggaagtt tccagaacta catctcacca 541 tcttgagtca gccttggctc agtgtccatc tcacaggcct ggaaggggca ggagtcagca 601 ctgtccagac cacagggcct gagtgtgggg agggcagccg tctaggaagg tggtggaggg 661 ttgttacctt gaggcaagag ggctgcgggg cagaaagaca cagcaggtga ctgttgtggg 721 aggcccaaga gaggcctggg agagggatgg cccacaaggg ctgaccctcc cgccacccag 781 ggggccttgg acaggtttcc tcctggcagg gtggcccttg tgcatggaac ccctacaacg 841 actaaggctg gcaggcatga ggtttcctga aggagaaaga gcttgtgggg cccagtgtgg 901 ctgggggggc gctgggactc cattctgaag ccaaaggcac tgggaagggc ttccgcagag 961 gagggtttgg caggggttgc caggaacagc ctggatgggg acagggaaca gataaggtgg 1021 gtggaggagt tagccgggagg cctggggctg gctccagcat gatgtggggg tctgcaaggc 1081 cctggagaaa gzggggtggt gcagcagggg gcacacccac agctggagct gacccagatg WO 00/09525 PCT/US99/17712 EPI-109 754 1141 gacagcttgg gctctgccac gcgggactag gcaaggaagg ggcacaaca agcaggaagt 1201 ggtgaggcgg tctccagcta gctgctctcc cctgcccaga ctttgg7zc ctccctgctg 1261 gcttggcctg gctccctggc tctgtgtggt atggtcacac ccccgzacac cccctccact 1321 gagatggggc ggggagagca ccgaggctgc tcttcctctc ctgggccgtc ctctgagcag 1381 cagacggggc taagcgttcc ccagctcgcc ttcacacaca gcccgt:zca ccacaccgac 1441 ggtaccatga aggacgaggt agctctactg gctgctgtca ccctcctcgg agtcctgctg 1501 caaggtgggc tggttcctat ctaggaagag ggtgggcctt agatcczzac agcttgccct 1561 ctgcccccta ggcccaggtg gagggcagag gtggggactc cagcccaggc ccaagctgga 1621 agagggtggg gactttcagg gaactggggg gcacctggct gtgagauctg taggacttgg 1681 gggtggcaag ggtgccagga caaatggtag gatagccatg ggctta~gga agctgatctc 1741 tgctctttcc agctgtcccc tctctgggcg tcccagcaag cggcccccat tccctggctc 1801 tgcttcaaag gcacctccat actgggacca cgtggagcag ggtagaggtg ggactccttc 1861 ctccagcccc ctaaaaagag cctgcttaat gcctttctca gactggccct aaaggacaca 1921 ttccttggcc agatatcctt gccacctaag agacaccact actccacagt gtgtgggcta 1981 ggataaggca cagcctgggg agggggctct gaaggggctg aacagacagg ccagcctgac 2041 ctccagctgc tcctgcactg agctggatgg ccaccctgtg acacccatct gcagagggcc 2101 cagaaccaaa ggtgccaggg ctgcaggact cagggggaga tggtccaacg ggaggtctgg 2161 ggagggagcg cacagccagc actggtctgt gtgtggtctg gcctggcctc acctgaccaa 2221 gagaagggct cctgcccaca gagaaacttt agggccagcc caccctctgc aactacccca 2281 gccctggggt cctggggtta ggctaggaga gtcccagctg caacctcctg ggagcaggag 2341 agaaggtgtc tgtcagattt aggcctggga ccggaatgca ggaacagaga aactgaggtt 2401 tggaggcaca gggacgcagg ctttagtgat cccggcctga ggcaggtca gagggccctg 2461 ctggtgggcg ctggtaggtg ggtgaccagg gactgttagc tacagggagt gtgcttcctt 2521 gcacctggga ggatgcagcc agctctgccc tcagactccc gaggcacztc ctggccaggg 2581 acctgaaagc tgcatttgcc tgtgttttga gagtgaaatg attcaaaaac aaggactcaa 2641 gtggtctctc tcgcggagca ggtgtccctg tgcctgaatc actcaccctc ccccatacac 2701 tcacaggttg ggacagggcc tctctgcgcc ccaggcttca gccctgccct cctcgctgaa 2761 tgtcagggac acagggcagg ccagggatgg gtgagacgag aggtctcctc gggcggggag 2821 ggggcggggt tccgccttag ggaggagagg acacggccaa gtgaagggcc agattgcagg 2881 atccctccca ctcccatctc tggggcttcg ggtgtccaga cctgaczccc gctccccctc 2941 ctcccccagc ctacttctcc ctgcaggtga tctcggcgcg cagggcctc cgcgtgtcgc 3001 cgccgctcac caccggccca cccgagttcg agcgcgtcta ccgagcccag tgaggcgcgg 3061 cgggagggcg cggggcgggg agcgagcccc aggcgggtcc gggtcgcagg accatcccgg 3121 ccggcgcgct catcccaccc gcccaccgca gggtgaactg cagcgagtac ttcccgctgt 3181 tcctcgccac gctctgggtc gccggcatct tctttcatga aggtcggggt gtggggcagg 3241 ggcgcacgcg ctggaccccc gggacccgcg cagggcgctc accaggcccg tgcgtacctc 3301 tcgcaggggc ggcggccctg tgcggcctgg tctacctgtt cgcgcgcctc cgctacttcc 3361 agggctacgc gcgctccgcg cagctcaggt gagggccggg cggggagcgg ggcggggccg 3421 gggaaagatc gcgggcgggc ggggctcctg gggagcggga ccgaaactgg gggcgggcga 3481 cgggccggag cccagcgcct ttggggattc ggtgggcgag ccctggcggc ggccagagga 3541 agtccccgtg gggccagggt tgcggcgggg aagaagcggg cctccrzgcg ccacctcccc 3601 gctgaccgcc gcccgcaggc tggcaccgct gtacgcgagc gcgcgcaccc tctggctgct 3661 ggtggcgctg gctgcgctcg gcctgctcgc ccacttcctc ccggccacgc tgcgcgccgc 3721 gctcctcgga cggctccgga cgctgctgcc gtgggcctga gaccaaagcc cccgggccga 3781 cggagccggg aaagaagagc cggagcctcc agctgccccg gggaggggcg ctcgcttccg 3841 catcctagtc tctatcatta aagttctagt gaccgagacc cgggctgcgt tctctgggtc 3901 cgcgggggtg gcgcaccgcg ggctacggag cctggagggg cccagcccga gtccgggcag 3961 cccggggcgg gcttcctagt ggcggcgtga gagtggctgc gaaggaacga gccctccccc 4021 tggggcggga ctggatccgg tcttcacctc ctaccccact ccctaccag cctcggggtc 4081 acaaggccgc ccagtcctgc cggggttcac cctcctagcg ctcagcggtc tcctcaccgg 4141 tccccctcct caggggcctt ccctcgactc tcagccgccg cagtccctcg tcccctggcc 4201 ttcacagctg acactagata gagcctgtgg ctctctcccc aggtgagggc aggggttttt 4261 cttttggtca gcactggatc cccctcgtta actgtaggtg ttcagggcag ccctccgagg 4321 tccgcagagc tgcgggcacc atgggaacga agtgagtcag tgacaggcgg tctcaaggaa 4381 atgtccagaa gccttgggga tccaggggag gcccacagaa acaaaaagt gacttttagc 4441 caagtatgca ggagaaacgg aggag (2) INFORMATION FOR SEQ ID NO:2578: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 5102 base pairs (B) TYPE: nucleic acid (C) STRAI4DEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2578: 1 tcttcctctc ctgggccgtc ctctgagcag cagacggggc taagcztcc ccagctcgcc 61 ttcacacaca gcccgtgcca ccacaccgac ggtaccatga aggacaggt agctctactg 121 gctgctgtca ccctcctggg agtcctgctg caagcctact tctcccagca ggtgatctcg 181 gcgcgcaggg cctccgcgt gtcgccgccg ctcaccaccg gcccacccga gttcgagcgc 241 gtctaccgag cccaggtgaa ctgcagcgag tactcccgc tgttcccgc cacgctctgg WO 00/09525 PCT/US99/17712 EPI-109 755 301 gtcgccggca tcttctttca tgaaggggcg gcggccctqt gcggcctggt ctacctgttc 361 gcgcgcctcc gctacttcca gggctacgcg cgctccgegc agctcaggct ggcaccgctg 421 tacgcgagcg cgcgcgccct ctggctgctg gtggcgctgg ctgcgctcgg cctgctcgcc 481 cacttcctcc cggccgcgct gcgcgccgcg ctcctcggac ggctccggac gctgctgccg 541 tgggcctgag accaaggccc ccgggccgac ggagccggga aagaagagcc ggagcctcca 601 gctgccccgg ggaggggcgc tcgcttccgc atcctagtct ctatcattaa agttctagtg 661 accga 1 gagctcacag agcccccagc tggggcatat ctggtttccg ggggcagggg cgatacccag 61 aggaggaaga agggattctg agagagccca acaggctccg agcctcaggc tggagctgag 121 cttggggcag caaggaagga ccaggtgcga gggcagaacc atgcggcccg acccctgcag 181 cacggcctgt ggcctccccc agctcctgcc cgtgcttctg ggtcagtctg gactttgcca 241 cttctgacca aaagccaccg caaacccact caagccaaaa gaggaagtga ccgttaggcc 301 caactgggaa ggctggcggc caggggcact ccaggcaggg cgaggggggc ggccgggggc 361 gctccaggcg gggcgaggga gacacccaga actccaggca ggagtcctcg ggtgccacct 421 ttcctctcca cctggccctg cgtgggctct gtcctcaggg tggcccgccg tagtccccct 481 ccccactctg agtttcctgt cccaaagtcc taaggaagtt tccagaacta catctcacca 541 tcttgagtca gccttggctc agtgtccatc tcacaggcct ggaaggggca ggagtcagca 601 ctgtccagac cacagggcct gagtgtgggg agggcagccg tctaggaagg tggtggaggg 661 ttgttacctt gaggcaagag ggctgcgggg cagaaagaca cagcaggtga ctgttgtggg 721 aggcccaaga gaggcctggg agagggatgg cccacaaggg ctgaccctcc cgccacccag 781 ggggccttgg acaggtttcc tcctggcagg gtggcccttg tgcatggaac ccctacaacg 841 actaaggctg gcaggcatga ggtttcctga aggagaaaga gcttgtgggg cccagtgtgg 901 ctgggggggc gctgggactc cattctgaag ccaaaggcac tgggaagggc ttccgcagag 961 gagggtttgg caggggttgc caggaacagc ctggatgggg acagggaaca gataaggtgg 1021 gtggaggagt tagccgggag cctggggctg gctccagcat gatgtggggg tctgcaaggc 1081 cctggagaaa gtggggtggt gcagcagggg gcacacccac agctggagct gacccagatg 1141 gacagcttgg gctctgccac gcgggactag gcaaggaagg ggcacgaaca agcaggaagt 1201 ggtgaggcgg tctccagcta gctgctctcc cctgcccaga ctttggtttc ctccctgctg 1261 gcttggcctg gctccctggc tctgtgtggt atggtcacac ccccgtgcac cccctccact 1321 gagatggggc ggggagagca ccgaggctgc tcttcctctc ctgggccgtc ctctgagcag 1381 cagacggggc taagcgttcc ccagctcgcc ttcacacaca gcccgtgcca ccacaccgac 1441 ggtaccatga aggacgaggt agctctactg gctgctgtca ccctcctggg agtcctgctg 1501 caaggtgggc tggttcctat ctaggaagag ggtgggcctt agatccctac agcttgccct 1561 ctgcccccta ggcccaggtg gagggcagag gtggggactc cagcccaggc ccaagctgga 1621 agagggtggg gactttcagg gaactggggg gcacctggct gtgagagctg taggacttgg 1681 gggtggcaag ggtgccagga caaatggtag gatagccatg ggcttgggga agctgatctc 1741 tgctctttcc agctgtcccc tctctgggcg tcccagcaag cggcccccat tccctggctc 1801 tgcttcaaag gcacctccat actgggacca cgtggagcag ggtagaggtg ggactccttc 1861 ctccagcccc ctaaaaagag cctgcttaat gcctttctca gactggccct aaaggacaca 1921 ttccttggcc agatatcctt gccacctaag agacaccact actccacagt gtgtgggcta 1981 ggataaggca cagcctgggg agggggctct gaaggggctg aacagacagg ccagcctgac 2041 ctccagctgc tcctgcactg agctggatgg ccaccctgtg acacccatct gcagagggcc 2101 cagaaccaaa ggtgccaggg ctgcaggact cagggggaga tggtccgacg ggaggtctgg 2161 ggagggagcg cacagccagc actggtctgt gtgtggtctg gcctggcctc acctgaccaa 2221 gagaagggct cctgcccaca gagaaacttt agggccagcc caccctctgc aactacccca 2281 gccctggggt cctggggtta ggctaggaga gtcccagctg caacctcctg ggagcaggag 2341 agaaggtgtc tgtcagattt aggcctggga ccggaatgca ggaacagaga aactgaggtt 2401 tggaggcaca gggacgcagg ctttagtgat cccggcctga ggcagggtca gagggccctg 2461 ctggtgggcg ctggtaggtg ggtgaccagg gactgttagc tacagggagt gtgcttcctt 2521 gcacctggga ggatgcagcc agctctgccc tcagactccc gaggcacttc ctggccaggg 2581 acctgaaagc tgcatttgcc tgtgttttga gagtgaaatg attcagaaac aaggactcaa 2641 gtggtctctc tcgcggagca ggtgtccctg tgcctgaatc actcaccctc ccccatacac 2701 tcacaggttg ggacagggcc tctctgcgcc ccaggcttca gccctgccct cctcgctgaa 2761 tgtcagggac acagggcagg ccagggatgg gtgagacgag aggtctcctc gggcggggag 2821 ggggcggggt tccgccttag ggaggagagg acacggccaa gtgaagggcc agattgcagg 2881 atccctccca ctcccatctc tggggcttcg ggtgtccaga cctgactccc gctccccctc 2941 ctcccccagc ctacttctcc ctgcaggtga tctcggcgcg cagggccttc cgcgtgtcgc 3001 cgccgctcac caccggccca cccgagttcg agcgcgtcta ccgagcccag tgaggcgcgg 3061 cgggagggcg cggggcgggg agcgagcccc aggcgggtcc gggtcgcagg accatcccgg 3121 ccggcgcgct catcccaccc gcccaccgca gggtgaactg cagcgagtac ttcccgctgt 3181 tcctcgccac gctctgggtc gccggcatct tctttcatga aggtcggggt gtggggcagg 3241 ggcgcacgcg ctggaccccc gggacccgcg cagggcgctc accaggcccg tgcgtacctc 3301 tcgcaggggc ggcggccctg tgcggcctgg tctacctgtt cgcgcgcctc cgctacttcc 3361 agggctacgc gcgctccgcg cagctcaggt gagggccggg cggggagcgg ggcggggccg 3421 gggaaagatc gcgggcgggc ggggctcctg gggagcggga ccgaagctgg gggcgggcga 3481 cgggccggag cccagcgcct ttggggattc ggtgggcgag ccctggcggc ggccagagga 3541 agtccccgtg gggccagggt tgcggcgggg aagaagcggg cctcctcgcg ccacctcccc 3601 gctgaccgcc gcccgcaggc tggcaccgct gtacgcgagc gcgcgcgccc tctggctgct WO 00/09525 PCT/US99/17712 EPI-109 756 3661 ggtggcgctg gctgcgczcg gcctgctcgc ccacttcctc ccggccgcgc tgcgcgccgc 3721 gctcctcgga cggctccgga cgctgctgcc gtgggcctga gaccaaggcc cccgggccga 3781 cggagccggg aaagaagagc cggagcctcc agctgccccg gggaggggcg ctcgcttccg 3841 catcctagtc tctatcarta aagttctagt gaccgagacc cgggctgcgt tctctgggtc 3901 cgcgggggtg gcgcaccgcg ggctacggag cctggagggg cccagcccga gtccgggcag 3961 cccggggcgg gcttcctagt ggcggcgtga gagtggctgc gaaggaacga gccctccccc 4021 tggggcggga ctggatccgg tcttcacctc ctaccccact ccctactcag cctcggggtc 4081 acaaggccgc ccagtcczgc cggggttcac cctcctagcg ctcagcggtc tcctcaccgg 4141 tccccctcct caggggcctt ccctcgactc tcagccgccg cagtccctcg tcccctggcc 4201 ttcacagctg acactagata gagcctgtgg ctctctcccc aggtgagggc aggggttttt 4261 cttttggtca gcactggatc cccctcgtta actgtaggtg ttcagggcag ccctccgagg 4321 tccgcagagc tgcgggcacc atgggaacga agtgagtcag tgacaggcgg tctcaaggaa 4381 atgtccagaa gccttgggga tccaggggag gcccacagaa acaaagaagt gacttttagc 4441 caagtatgca ggagaaacgg aggag (2) INFORMATION FOR SEQ ID NO:2579: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 3001 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2579: 1 gccattctct cacatcccgt gcggtcagga agcccttcct gaactctgac ttcagttctt 61 gctgcggttt ctgcccattt ttttcatatc ctctgacagc tgcgaggtca tctctgctct 121 ggcttttctc caagcagaac aagtgggggc tctggaaagg ttaagggacc tcagtggcca 181 ccattatact ttgcatcttt cctgagaagt gagagttgaa agggaagcag gaaggcccat 241 ggtcagattg aaggaaggac tttttagttt cttttttttt tttttgaaat ggagtctcgc 301 tctgtcattc aggctggagt gcagtggtgc gatctcagct cactgcagcc tccacttcct 361 gggttcacat gattctcctg cctcagcctc ccaagtagct gagactacag gcacatgcca 421 ctacacccag ctaacttttg tatttttagt agagacgggg tttcaccatg ttggccaggc 481 tggtctcaaa ctgctaacat caagtgatct gctcccctca gcctcccaaa gtgctgggat 541 taccggtatg aaccaccaca acctgccagg aatttttagt ttttagcttt tgcaggagac 601 ttcaaggaaa ggagacattc ctctgtccag gaaacgggta aggggaccat ttctgcattg 661 ctggtttccc ctcttggcag ggtgggcatg aggcatcact gttcctgctc cctcactcct 721 gctcctcatg ctcagcctgc cagctcggcc tcaactttgt gtgtctaaag tggaactgaa 781 tagtagctgt gagaagatag gaaagaggta gtgccaatct ccttgcccag atcataaatc 841 cagactcagc agggtaacca catgggcaag cacaaggtag gtgcttgggg aaaggggaag 901 taattggcat tctgtgtgat accaaggaga ccatttggat tttggcttct accaaagaga 961 atggagaatt ggttgaccta aatggaacca gtccctttaa gtaaggggag gaaagggggt 1021 gctggaagat ggccctcttc ccaccaccta gatcatagct tgaactgaag ccaaggacag 1081 agtgctgccc ccttcggcat ttactgatgt gccctcttta aatcatgatg ttatctaacc 1141 caaacccaga cccaggacct agtcacagct ccaacctaca cttcctatta atcttaaaac 1201 aaagcgaaac aaacacaaaa agatatcagc attgtagcct ccaatctgag cccatttccc 1261 ttctctggct accatacctc cttctcctat atgataccat tcactacttt gttcaattat 1321 ccagtctaga cctgcatctt gaggccacac ccagccttct cactccccac acccctcttt 1381 cctctctcac tgctccttcc tggtctcttc tcatctggcc ccacctctaa ggagtcctcc 1441 tgccttctgg gttgccctgg aaaacagact atcccccctc ctagtgaagg gagtgggtag 1501 gggtttcagc cccaccctca ggaagatgcg tcttccctgt cctctgctct gtggtacttc 1561 ctctctggct gatttagcaa acagcaccta gacctggggc caggcctttg gcagtgggac 1621 agatccaggg ataggcaca ccaccctgcc ctgaccctgg gattggcatc agcttccaac 1681 cagttcctgc caaagcttgt aagtcctccc gacggccatg aacactacat cttctgcagc 1741 acccccctca ctaggtgtag agttcatctc tctgctggct atcatcctgc tgtcagtggc 1801 gctggctgtg gggcttcccg gcaacagctt tgtggtgtgg agtatcctga aaaggatgca 1861 gaagcgctct gtcactgccc tgatggtgct gaacctggcc ctggccgacc tggccgtatt 1921 gctcactgct ccctttttcc ttcacttcct ggcccaaggc acctggagtt ttggactggc 1981 tggttgccgc ctgtgtcact atgtctgcgg agtcagcatg tacgccagcg tcctgcttat 2041 cacggccatg agtctagacc gctcactggc ggtggcccgc ccctttgtgt cccagaagct 2101 acgcaccaag gcgatggccc ggcgggtgct ggcaggcatc tgggtgttgt cctttctgct 2161 ggccacaccc gtcctcgcgt accgcacagt agtgccctgg aaaacgaaca tgagcctgtg 2221 cttcccgcgg taccccagcg aagggcaccg ggccttccat ctaatcttcg aggctgtcac 2281 gggcttcctg ctgcccttcc tggctgtggt ggccagctac tcggacatag ggcgtcggct 2341 acaggcccgg cgcttccgcc gcagccgccg caccggccgc ctggtggtgc tcatcatcct 2401 gaccttcgcc gccttctggc tgccctacca cgtggtgaac ctggctgagg cgggccgcgc 2461 gctggccggc caggccgccg ggttagggct cgtggggaag cggctgagcc tggcccgcaa 2521 cgtgctcatc gcactcgcct tcctgagcag cagcgtgaac cccgtgctgt acgcgtgcgc 2581 cggcggcggc ctgctgcgct cggcgggcgt gggcttcgtc gccaagctgc tggagggcac 2641 gggttccgag gcgtccagca cgcgccgcgg gggcagcctg ggccagaccg ctaggagcgg 2701 ccccgccgct ctggagcccg gcccttccga gagcctcact gcctccagcc ctctcaagtt 2761 aaacgaactg aactaggcct ggtggaagga ggcgcacttt cctcctggca gaatgctagc WO 00/09525 PCT/US99/17712 EPI-109 757 2821 tctgagccag ttcagtacct ggaggaggag caggggcgtg gagggcgtgg agggcgtggg 2881 agcgtgggag gcgggagzgg agtggaagaa gagggagaga tggagcaaag tgagggccga 2941 gtgagagcgt gctccagcct ggctcccaca ggcagcttta accattaaaa ctgaagtctg 3001 aa (2) INFORMATION FOR SEQ ID NO:2580: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 841 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2580: 1 aaaagaagga cctgggcttt gggaagatct aaagacccag gaaggtctct gggtgggata 61 aagccaagat gaaactcccc ctacttctgg ctcttctatt tggggcagtt tctgctcttc 121 atctaaggtc tgagacttcc acctttgaga cccctttggg tgctaagacg ctgcctgagg 181 atgaggagac accagagcag gagatggagg agaccccttg cagggagctg gaggaagagg 241 aggagtgggg ctctggaagt gaagatgcct ccaagaaaga tggggctgtt gagtctatct 301 cagtgccaga tatggtgcac aaaaacctta cgtgtcctga ggaagaggac acagtaaaag 361 tggtgggcat ccctgggtgc cagacctgcc gctacctcct ggtgagaagt cttcagacgt 421 ttagtcaagc ttggtttact tgccggaggt gctacagggg caacctggtt tccatccaca 481 acttcaatat taattatcga atccagtgtt ctgtcagcgc gctcaaccag ggtcaagtct 541 ggattggagg caggatcaca ggctcgggtc gctgcagacg ctttcagtgg gttgacggca 601 gccgctggaa ctttgcgtac tgggctgctc accagccctg gtcccgcggt ggtcactgcg 661 tggccctgtg tacccgagga ggctactggc gtcgagccca ctgcctcaga agacttcctt 721 tcatctgttc ctactgagct ggtcccagcc agcagttcau egctgccctc tcctgggcag 781 ctgcctcccc tcctctgctt gccatccctc cctccacctc cctgcaataa aatgggtttt 841 actgaaaa (2) INFORMATION FOR SEQ ID NO:2581: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 841 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO 2581: 1 aaaagaagga cctgggcttt gggaagatct aaagacccag gaaggtctct gggtgggata 61 aagccaagat gaaactcccc ctacttctgg ctcttctatt tggggcagtt tctgctcttc 121 atctaaggtc tgagacttcc acctttgaga cccctttggg tgctaagacg ctgcctgagg 181 atgaggagac accagagcag gagatggagg agaccccttg cagggagctg gaggaagagg 241 aggagtgggg ctctggaagt gaagatgcct ccaagaaaga tggggctgtt gagtctatct 301 cagtgccaga tatggtggac aaaaacctta cgtgtcctga ggaagaggac acagtaaaag 361 tggtgggcat ccctgggtgc cagacctgcc gctacctcct ggtgagaagt cttcagacgt 421 ttagtcaagc ttggtttact tgccggaggt gctacagggg caacctggtt tccatccaca 481 acttcaatat taattatcga atccagtgtt ctgtcagcgc gctcaaccag ggtcaagtct 541 ggattggagg caggatcaca ggctcgggtc gctgcagacg ctttcagtgg gttgacggca 601 gccgctggaa ctttgcgtac tgggctgctc accagccctg gtcccgcggt ggtcactgcg 661 tggccctgtg tacccgagga ggctactggc gtcgagccca ctgcctcaga agacttcctt 721 tcatctgttc ctactgagct ggtcccagcc agcagttcag agctgccctc tcctgggcag 781 ctgcctcccc tcctctgctt gccatccctc cctccacctc cctgcaataa aatgggtttt 841 actgaaaa (2) INFORMATION FOR SEQ ID NO:2582: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1682 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2582 1 aaaagaagga cctgggcttt gggaagatct aaagacccag gaaggtctct gggtgggata 61 aagccaagat gaaactcccc ctacttctgg ctcttctatt tggggcagtt tctgctcttc 121 atctaaggtc tgagacttcc acctttgaga cccctttggg tgctaagacg ctgcctgagg 181 atgaggagac accagagcag gagatggagg agaccccttg cagggaactg gaggaagagg 241 aggagtgggg ctctggaagt gaagatgcct ccaagaaaga tggggctgtt gagtctatct 301 cagtgccaga tatggtgcac aaaaacctta cgtgtcctga ggaagaggac acagtaaaag 361 tggtgggcat ccctgggtgc cagacctgcc gctacctcct ggtgagaagt cttcagacgt 421 ttagtcaagc ttggtttact tgccggaggt gctacagggg caacctggtt tccatccaca 481 acttcaatat taattatcga atccagtgtt ctgtcagcgc gctcaaccag ggtcaagtct 541 ggattggagg caggatcaca ggctcgggtc gctgcagacg ctttcagtgg gttgacggca 601 gccgctggaa ctttgcgtac tgggctgctc accagccctg gtcccacggt ggtcactgcg 661 tggccctgtg tacccgagga ggctactggc gtcgagccca ctgcctcaga agacttcctt WO 00/09525 PCT/US99/17712 EPI-109 758 721 tcatctgttc ctactgagct ggtcccagcc agcagttcag agctgccctc tcctgggcag 781 ctgcctcccc tcctctgctt gccatccctc cctccacctc cctgcaataa aatgggtttt 841 actgaaaa 1 aaaagaagga cctgggcttt gggaagatct aaagacccag gaaggtctct gggtgggata 61 aagccaagat gaaactcccc ctacttctgg ctcttctatt tggggcagtt tctgctcttc 121 atctaaggtc tgagacttcc acctttgaga cccctttggg tgctaagacg ctgcctgagg 181 atgaggagac accagagcag gagatggagg agaccccttg cagggagctg gaggaagagg 241 aggagtgggg ctctggaagt gaagatgcct ccaagaaaga tggggczgtt gagtctatct 301 cagtgccaga tatggtggac aaaaacctta cgtgtcctga ggaagaggac acagtaaaag 361 tggtgggcat ccctgggtgc cagacctgcc gctacctcct ggtgagaagt cttcagacgt 421 ttagtcaagc ttggtttact tgccggaggt gctacagggg caacctggtt tccatccaca 481 acttcaatat taattatcga atccagtgtt ctgtcagcgc gctcaaccag ggtcaagtct 541 ggattggagg caggatcaca ggctcgggtc gctgcagacg ctttcagtgg gttgacggca 601 gccgctggaa ctttgcgtac tgggctgctc accagccctg gtcccgcggt ggtcactgcg 661 tggccctgtg tacccgagga ggctactggc gtcgagccca ctgccrcaga agacttcctt 721 tcatctgttc ctactgagct ggtcccagcc agcagttcag agctgccctc tcctgggcag 781 ctgcctcccc tcctctgctt gccatccctc cctccacctc cctgcaataa aatgggtttt 841 actgaaaa (2) INFORMATION FOR SEQ ID NO:2583: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 781 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO: 2583 1 agcagagggg ctgagaccaa accagaaacc tccaattctc atgtggaagc ccatgccctc 61 accctccaac atgaaagcct ctgcagcact tctgtgtctg ctgctcacag cagctgcttt 121 cagcccccag gggcttgctc agccagttgg gattaatact tcaactacct gctgctacag 181 atttatcaat aagaaaatcc ctaagcagag gctggagagc tacagaagga ccaccagtag 241 ccactgtccc cgggaagctg taatcttcaa gaccaaactg gacaaggaga tctgtgctga 301 ccccacacag aagtgggtcc aggactttat gaagcacctg gacaagaaaa cccaaactcc 361 aaagctttga acattcatga ctgaactaaa aacaagccat gacttgagaa acaaataatt 421 tgtataccct gtcctttctc agagtggttc tgagattatt ttaatctaat tctaaggaat 481 atgagcttta tgtaataatg tgaatcatgg tttttcttag tagattttaa aagttattaa 541 tattttaatt taatcttcca tggattttgg tgggttttga acataaagcc ttggatgtat 601 atgtcatctc agtgctgtaa aaactgtggg atgctcctcc cttctctacc tcatgggggt 661 attgtataag tccttgcaag aatcagtgca aagatttgct ttaattgtta agatatgatg 721 tccctatgga agcatattgt tattatataa ttacatattt gcatatgtat gactcccaaa 781 ttttcacata aaatagattt ttgtaaaaaa (2) INFORMATION FOR SEQ ID NO:2584: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1081 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO: 2584 1 ggtttctatt gacttgggtt aatcgtgtga ccgcggtggc tggcacaaaa ttgaccaacc 61 ctggggttag tatagcttag ttaaactttc gtttattgct aaaggttaat cactgctgtt 121 tcccgtgggg gtgtggctag gctaagcgtt ttgagctgca ttgctacgtg cttgatgctt 181 gtcccttttg atcgtggtga tttagagggt gaactcactg gaatgaggat gcttgcatgt 241 gtaatcttac taagagctaa tagaaaggct aggaccaaac cagaaacctc caattctcat 301 gtggaagccc atgccctcac cctccaacat gaaagcctct gcagcacttc tgtgtctgct 361 gctcacagca gctgctttca gcccccaggg gcttgctcag ccagttggga ttaatacttc 421 aactacctgc tgctacagat ttatcaataa gaaaatccct aagcagaggc tggagagcta 481 cagaaggacc accagtagcc actgtccccg ggaagctgta atcttcaaga ccaaactgga 541 caaggagatc tgtgctgacc ccacacagaa gtgggtccag gactttatga agcacctgga 601 caagaaaacc caaactccaa agctttgaac attcatgact gaactgaaaa caagccatga 661 cttgagaaac aaataatttg tataccctgt cctttctcag agtggttctg agattattt 721 aatctaattc taaggaatat gagctttatg taataatgtg aatcatggtt tttcttagta 781 gattttaaaa gttattaata ttttaattta atcttccatg gattttggtg ggttttgaac 841 ataaagcctt ggatgtatat gtcatctcag tgctgtaaaa actgtgggat gctcctccct 901 tctctacctc argggggtat tgtataagtc cttgcaagaa tcagtgcaaa gatttgcttt 961 aattgttaag atatgatgtc cctatggaag catattgtta ttatazaatt acatatttgc 1021 atatgtatga ctcccaaatt ttcacataaa atagattttt gtataacaaa aaaaaaaaaa 1081 aaaaa (2) INFORMATION FOR SEQ ID NO:2585: (i) SEQUENCE CHARACTERISTICS: WO 00/09525 PCT/US99/17712 EPI-109 759 (A) LENGTH: 1081 base pairs (B) TYPE: nucieic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO: 2585 1 ggtttctatt gacttgggtt aatcgtgtga ccgcggtggc tggcacgaaa ttgaccaacc 61 ctggggttag ratagcttag ttaaactttc gtttattgct aaaggttaat cactgctgtt 121 tcccgtgggg gtgtggctag gctaagcgtt ttgagctgca ttgctgcgtg cttgatgctt 181 gtcccttttg atcgtggtga tttagagggt gaactcactg gaatggggat gcttgcatgt 241 gtaatcttac taagagctaa tagaaaggct aggaccaaac cagaaacctc caattctcat 301 gtggaagccc atgccctcac cctccaacat gaaagcctct gcagcacttc tgtgtctgct 361 gctcacagca gctgctttca gcccccaggg gcttgctcag ccagttggga tcaatacttc 421 aactacctgc tgctacagat ttatcaataa gaaaatccct aagcagaggc tggagagcta 481 cagaaggacc accagtagcc actgtccccg ggaagctgta atcttcaaga ccaaactgga 541 caaggagatc tgtgctgacc ccacacagaa gtgggtccag gactttatga agcacctgga 601 caagaaaacc caaactccaa agctttgaac attcatgact gaactgaaaa caagccatga 661 cttgagaaac aaataatttg tataccctgt cctttctcag agtggttctg agattatttt 721 aatctaattc taaggaatat gagctttatg taataatgtg aatcatggtt tttcttagta 781 gattttaaaa gttattaata ttttaattta atcttccatg gattttggtg ggttttgaac 841 ataaagcctt ggatgtatat gtcatctcag tgctgtaaaa actgtgggat gctcctccct 901 tctctacctc atgggggtat tgtataagtc cttgcaagaa tcagtgcaaa gatttgcttt 961 aattgttaag atatgatgtc cctatggaag catattgtta ttatataatt acatatttgc 1021 atatgtatga ctcccaaatt ttcacataaa atagattttt gtataacaaa aaaaaaaaaa 1081 aaaaaa (2) INFORMATION FOR SEQ ID NO:2586: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 2881 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO: 2586 1 ggatccttaa gccatcatgc aaaatatcta gccatgtgga gggaccactg gaaagatcac 61 acacacacac acacacacac acacacacac atacagagag agagagagac acctgagaaa 121 ttccatctgg tccaactgct ggctgttgaa gtcctcccag cccagacccc agacactgaa 181 tgaaggcctt gtgatatagt caagagcaaa aaaacccaga agattgttat tgttttaagt 241 cactgttttc agatagattg ctatgcagca atagattatt gaaatagaca ctacaatttt 301 aggtactatt attctaagaa tattgaattt tatttttctg ctaatgttct attattttac 361 ttttctctgg gttttagaaa gccaccagga tttaagacag tgaagaatct ttgagtcctt 421 tgtagagttg aaccaaagtt tgaatgtctc tttgtggact cgtgtcctag ggataccact 481 ccaaagggaa aaggggaata tcccttacat atctttgact ttggtatccc tgattccttc 541 ctttttctat agaatgtgtc tcatttcaga gaaactggtc tcttgataat agccatagat 601 tacatactgt ggtcttcctc tacatagacc ctacctcacc taccactcct ggtcttagct 661 gaaaaacagg ctagcctcga ctcatactgt catttcctat cctcccactg aaggcactg 721 gctcagcaga tttattactc catagattta ttactccatt ctatgattca tcctctctgc 781 ttcctataaa aggcagagac agagcttcca gaggagcaga ggggctgaga ccaaaccaga 841 aacctccaat tctcatgtgg aagcccatgc cctcaccctc caacatgaaa gcctctgcag 901 cacttctgtg tctgctgctc acagcagctg ctttcagccc ccaggggctt gctcagccag 961 gtaaggtccc tctctccttc tccttgaagc acattgcccc ctctctgggt tatcctggac 1021 caatcaagaa gacctgatac ccacagtctc actttaacag ctacttttcc aagataaggt 1081 aacttagaaa aaggataagg ggtgagccca accacacagc tgctgttggg tagagcctga 1141 actagaattc cagctgtgaa ccccaaatcc agctccttct aggattccag ctctgggaac 1201 accctcagtg cagttaccac tccagctgct tccagcagaa tttgggatca gggtgatcaa 1261 agacaggagg cttctgggga tgggtgtgcg ggctgtttcc agataccggg agacccagaa 1321 tctggtctgt ggaagcccag cttccagaaa cagcagctct gcagaggtgg tacgtatcag 1381 ggaaactcat gaccaagcat tgaatgctca gagcctaaaa ggggatccat agttggggta 1441 cccttgctct aaggaattgg attattatat tagcccctcc tagcaatgcc cagagtagcc 1501 atcaattcct cttccgtctt tcaactggtg atggtgcatc cctatttcac agtccataaa 1561 agtgaaaggg agtttatgaa atgcctcaaa gggcagagac attgggtttg ggatgggcag 1621 cttttccctc cacctcttcc tttctttctg attccttctt cttaccattc cctgttttac 1681 aaacagaaag acccaggaca caccctcaat ggacttttct tcttgttgtt tcattgcagt 1741 tgggattaat acttcaacta cctgctgcta cagatttatc aataagaaaa tccctaagca. 1801 gaggctggag agctacagaa ggaccaccag tagccactgt ccccgggaag ctgtaatgta 1861 tgtggacgat gaccacccac ccctcacacc tcagtcctag gttcttccct gggcagggaa 1921 taggactagt atcagaatga gttggagtca aatactgtga tgcatacagc atctctaacc 1981 ttatcccaga catttgccag tgagaaacaa. tacaagtaaa gaaagtggct tctcactctc 2041 agctcccttt ccagctatca ttttacatct cagttcgttc cttcatcctg gaaccaagag 2101 agattcactt gggctaccaa aaagagctgc ttctctgagt ccccttcctt tgttttatct 2161 tcttccttca tccctgaggc atccccatca gctaggctga tgggctagac agatttccca WO 00/09525 PCT/US99/17712 EPI-109 760 2221 tagacttggt cacactccca ggctgaaccc tcaaggtgtt ccatctgact gtctcctttc 2281 tgctccacag cttcaagacc aaactggaca aggagatctg tgctgacccc acacagaagt 2341 gggtccagga ctttatgaag cacctggaca agaaaaccca aactccaaag ctttgaacat 2401 tcatgactga actgaaaaca agccatgact tgagaaacaa ataatttgta taccctgtcc 2461 tttctcagag tggttctgag attattttaa tctaattcta aggaatatga gctttatgta 2521 ataatgtgaa tcatggtttt tcttagtaga ttttaaaagt tattaatatt ttaatttaat 2581 cttccatgga ttttggtggg ttttgaacat aaagccttgg atgtatatgt catctcagtg 2641 ctgtaaaaac tgtgggatgc tcctcccttc tctacctcat gggggtattg tataagtcct 2701 tgcaagaatc agtgcaaaga tttgctttaa ttgttaagat atgatgtccc tatggaagca 2761 tattgttatt atataattac atatttgcat atgtatgact cccaaatttt cacataaaat 2821 agatttttgt ataacagctg ccattcatgg ttttttaaag gataagtaat aaagctggtg 2881 gggta (2) INFORMATION FOR SEQ ID NO:2587: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 5824 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO: 2587 1 agcagagggg ctgagaccaa accagaaacc tccaattctc atgtggaagc ccatgccctc 61 accctccaac atgaaagcct ctgcagcact tctgtgtctg ctgctcacag cagctgcttt 121 cagcccccag gggcttgctc agccagttgg gattaatact tcaactacct gctgctacag 181 atttatcaat aagaaaatcc ctaagcagag gctggagagc tacagaagga ccaccagtag 241 ccactgtccc cgggaagctg taatcttcaa gaccaaactg gacaaggaga tctgtgctga 301 ccccacacag aagtgggtcc aggactttat gaagcacctg gacaagaaaa cccaaactcc 361 aaagctttga acattcatga ctgaactaaa aacaagccat gacttgagaa acaaataatt 421 tgtataccct gtcctttctc agagtggttc tgagattatt ttaatctaat tctaaggaat 481 atgagcttta tgtaataatg tgaatcatgg tttttcttag tagattttaa aagttattaa 541 tattttaatt taatcttcca tggattttgg tgggttttga acataaagcc ttggatgtat 601 atgtcatctc agtgctgtaa aaactgtggg atgctcctcc cttctctacc tcatgggggt 661 attgtataag tccttgcaag aatcagtgca aagatttgct ttaattgtta agatatgatg 721 tccctatgga agcatattgt tattatataa ttacatattt gcatatgtat gactcccaaa 781 ttttcacata aaatagattt ttgtaaaaaa 1 ggtttctatt gacttgggtt aatcgtgtga ccgcggtggc tggcacgaaa ttgaccaacc 61 ctggggttag tatagcttag ttaaactttc gtttattgct aaaggttaat cactgctgtt 121 tcccgtgggg gtgtggctag gctaagcgtt ttgagctgca ttgctgcgtg cttgatgctt 181 gtcccttttg atcgtggtga tttagagggt gaactcactg gaatggggat gcttgcatgt 241 gtaatcttac taagagctaa tagaaaggct aggaccaaac cagaaacctc caattctcat 301 gtggaagccc atgccctcac cctccaacat gaaagcctct gcagcacttc tgtgtctgct 361 gctcacagca gctgctttca gcccccaggg gcttgctcag ccagttggga ttaatacttc 421 aactacctgc tgctacagat ttatcaataa gaaaatccct aagcagaggc tggagagcta 481 cagaaggacc accagtagcc actgtccccg ggaagctgta atcttcaaga ccaaactgga 541 caaggagatc tgtgctgacc ccacacagaa gtgggtccag gactttatga agcacctgga 601 caagaaaacc caaactccaa agctttgaac attcatgact gaactgaaaa caagccatga 661 cttgagaaac aaataatttg tataccctgt cctttctcag agtggttctg agattatttt 721 aatctaattc taaggaatat gagctttatg taataatgtg aatcatggtt tttcttagta 781 gattttaaaa gttattaata ttttaattta atcttccatg gattttggtg ggttttgaac 841 ataaagcctt ggatgtatat gtcatctcag tgctgtaaaa actgtgggat gctcctccct 901 tctctacctc atgggggtat tgtataagtc cttgcaagaa tcagtgcaaa gatttgcttt 961 aattgttaag atatgatgtc cctatggaag catattgtta ttatataatt acatatttgc 1021 atatgtatga ctcccaaatt ttcacataaa atagattttt gtataacaaa aaaaaaaaaa 1081 aaaaa 1 ggtttctatt gacttgggtt aatcgtgtga ccgcggtggc tggcacgaaa ttgaccaacc 61 ctggggttag tatagcttag ttaaactttc gtttattgct aaaggttaat cactgctgtt 121 tcccgtgggg gtgtggctag gctaagcgtt ttgagctgca ttgctgcgtg cttgatgctt 181 gtcccttttg atcgtggtga tttagagggt gaactcactg gaatggggat gcttgcatgt 241 gtaatcttac taagagctaa tagaaaggct aggaccaaac cagaaacctc caattctcat 301 gtggaagccc atgccctcac cctccaacat gaaagcctct gcagcacttc tgtgtctgct 361 gctcacagca gctgctttca gcccccaggg gcttgctcag ccagttggga ttaatacttc 421 aactacctgc tgctacagat ttatcaataa gaaaatccct aagcagaggc tggagagcta 481 cagaaggacc accagtagcc actgtccccg ggaagctgta atcttcaaga ccaaactgga 541 caaggagatc tgtgctgacc ccacacagaa gtgggtccag gactttatga agcacctgga 601 caagaaaacc caaactccaa agctttgaac attcatgact gaactgaaaa caagccatga 661 cttgagaaac aaataatttg tataccctgt cctttctcag agtggttctg agattatttt 721 aatctaattc taaggaatat gagctttatg taataatgtg aatcatggtt tttcttagta 781 gattttaaaa gttattaata ttttaattta atcttccatg gattttggtg ggttttgaac 841 ataaagcctt ggatgtatat gtcatctcag tgctgtaaaa actgtgggat gctcctccct 901 tctctacctc atgggggtat tgtataagtc cttgcaagaa tcagtgcaaa gatttgcttt WO 00/09525 PCTIUS99/17712 EPI-109 761 961 aattgttaag atatgatgtc cctatggaag catattgtta ttataraatt acatatttgc 1021 atatgtatga ctcccaaatt ttcacataaa atagattttt gtataacaaa aaaaaaaaaa 1081 aaaaa 1 ggatccttaa gccatcatgc aaaatatcta gccatgtgga gggaccactg gaaagatcac 61 acacacacac acacacacac acacacacac atacagagag agagagagac acctgagaaa 121 ttccatctgg tccaactuct ggctgttgaa gtcctcccag cccagacccc agacactgaa 181 tgaaggcctt gtgatatagt caagagcaaa aaaacccaga agattgttat tgttttaagt 241 cactgttttc agatagattg ctatgcagca atagattatt gaaatagaca ctacaatttt 301 aggtactatt attctaaaa tattgaattt tatttttctg ctaatgttct attattttac 361 ttttctctgg gttttagaaa gccaccagga tttaagacag tgaagaatct ttgagtcctt 421 tgtagagttg aaccaaagtt tgaatgtctc tttgtggact cgtgtcctag ggataccact 481 ccaaagggaa aaggggaaca tcccttacat atctttgact ttggtatccc tgattccttc 541 ctttttctat agaatgtgtc tcatttcaga gaaactggtc tcttgaraat agccatagat 601 tacatactgt ggtcttcctc tacatagacc ctacctcacc taccactcct ggtcttagct 661 gaaaaacagg ctagcctcga ctcatactgt catttcctat cctcccactg aagtgcactg 721 gctcagcaga tttattactc catagattta ttactccatt ctatgatca tcctctctgc 781 ttcctataaa aggcagagac agagcttcca gaggagcaga ggggctgaga ccaaaccaga 841 aacctccaat tctcatgtgg aagcccatgc cctcaccctc caacatgaaa gcctctgcag 901 cacttctgtg tctgctgctc acagcagctg ctttcagccc ccaggggctt gctcagccag 961 gtaaggtccc tctctccttc tccttgaagc acattgcccc ctctctgggt tatcctggac 1021 caatcaagaa gacctgatac ccacagtctc actttaacag ctacttttcc aagataaggt 1081 aacttagaaa aaggataagg ggtgagccca accacacagc tgctgttggg tagagcctga 1141 actagaattc cagctgtgaa ccccaaatcc agctccttct aggattccag ctctgggaac 1201 accctcagtg cagttaccac tccagctgct tccagcagaa tttgggatca gggtgatcaa 1261 agacaggagg cttctgggga tgggtgtgcg ggctgtttcc agataccggg agacccagaa 1321 tctggtctgt ggaagcccag cttccagaaa cagcagctct gcagaggtgg tacgtatcag 1381 ggaaactcat gaccaagcat tgaatgctca gagcctaaaa ggggatocat agttggggta 1441 cccttgctct aaggaattgg attattatat tagcccctcc tagcaatgcc cagagtagcc 1501 atcaattcct cttccgtctt tcaactggtg atggtgcatc cctatttcac agtccataaa 1561 agtgaaaggg agtttatgaa atgcctcaaa gggcagagac attgggtttg ggatgggcag 1621 cttttccctc cacctcttcc tttctttctg attccttctt cttaccattc cctgttttac 1681 aaacagaaag acccaggaca caccctcaat ggacttttct tcttgttgtt tcattgcagt 1741 tgggattaat acttcaacta cctgctgcta cagatttatc aataagaaaa tccctaagca 1801 gaggctggag agctacagaa ggaccaccag tagccactgt ccccgggaag ctgtaatgta 1861 tgtggacgat gaccacccac ccctcacacc tcagtcctag gttcttccct gggcagggaa 1921 taggactagt atcagaatga gttggagtca aatactgtga tgcatacagc atctctaacc 1981 ttatcccaga catttgccag tgagaaacaa tacaagtaaa gaaagtggct tctcactctc 2041 agctcccttt ccagctatca ttttacatct cagttcgttc cttcatcctg gaaccaagag 2101 agattcactt gggctaccaa aaagagctgc ttctctgagt ccccttcctt tgttttatct 2161 tcttccttca tccctgaggc atccccatca gctaggctga tgggcragac agatttccca 2221 tagacttggt cacactccca ggctgaaccc tcaaggtgtt ccatctgact gtctcctttc 2281 tgctccacag cttcaagacc aaactggaca aggagatctg tgctgacccc acacagaagt 2341 gggtccagga ctttatgaag cacctggaca agaaaaccca aactccaaag ctttgaacat 2401 tcatgactga actgaaaaca agccatgact tgagaaacaa ataatttgta taccctgtcc 2461 tttctcagag tggttctgag attattttaa tctaattcta aggaatatga gctttatgta 2521 ataatgtgaa tcatggtttt tcttagtaga ttttaaaagt tattaatatt ttaatttaat 2581 cttccatgga ttttggtggg ttttgaacat aaagccttgg atgtatatgt catctcagtg 2641 ctgtaaaaac tgtgggatgc tcctcccttc tctacctcat gggggtattg tataagtcct 2701 tgcaagaatc agtgcaaaga tttgctttaa ttgttaagat atgatgtccc tatggaagca 2761 tattgttatt atataattac atatttgcat atgtatgact cccaaatttt cacataaaat 2821 agatttttgt ataacagctg ccattcatgg ttttttaaag gataagtaat aaagctggtg 2881 gggta (2) INFORMATION FOR SEQ ID NO:2588: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 721 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO: 2588 1 aaccgagagg ctgagactaa cccagaaaga tccaattctc aaactgaagc tcgcactctc 61 gcctccagca tgaaagtctc tgccgccctt ctgtgcctgc tgctcazagc agccaccttc 121 attccccaag ggctcgctca gccagatgca atcaatgccc cagtcacctg ctgttataac 181 ttcaccaata ggaagatctc agtgcagagg ctcgcgagct atagaagaat caccagcagc 241 aagtgtccca aagaagctgt gatcttcaag accattgtgg ccaaggagat ctgtgctgac 301 cccaagcaga agtgggttca ggattccatg gaccacctgg acaagcaaac ccaaactccg 361 aagacttgaa cactcactcc acaacccaag aatctgcagc taacttattt tcccctagct 421 ttccccagac accctgtttc attttattat aatgaatttt gtttgt-gat gtgaaacatt 481 atgccttaag taatgttaa g tcttatttaa gttattgatg ttttaagttt atctttcatg WO 00/09525 PCT/US99/17712 EPI-109 762 541 gtactagtgt trtttagata cagagacttg gggaaattgc ttttcczctt gaaccacagt 601 tctacccctg ggatgttttg agggtctttg caagaatcat taatacaaag aatttttttt 661 aacattccaa tgcattgcta aaatattatt gtggaaatga atattzgta actattacac 721 caaataaata tatttttgta c (2) INFORMATION FOR SEQ ID NO:2589: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1501 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO: 2589 1 agcccatgtc ctctcttttc aggtgatgac tttcccctga ggaagccctg tagcgtgcct 61 ggaggaaggg gctctccaac cccagcccca cctagccacc atgaacactt cagccccacc 121 tgctgtcagc cccaacatca ccgtcctggc accaggaaag ggtccczggc aagtggcctt 181 cattgggatc accacgggcc tcctgtcgct agccacagtg acaggcaacc tgctggtact 241 catctctttc aaggtcaaca cggagctcaa gacagtcaat aactacttcc tgctgagcct 301 ggcctgtgct gacctcatca tcggtacctt ctccatgaac ctctatacca cgtacctgct 361 catgggccac tgggctctgg gcacgctggc ttgtgacctc tggctggccc tggactatgt 421 ggccagcaat gcctccgtca tgaatctgct gctcatcagc tttgaccgct acttctccgt 481 gactcggccc ctgagctacc gtgccaagcg cacaccccgc cgggcauctc tgatgatcgg 541 cctggcctgg ctggtttcct ttgtgctctg ggccccagcc atcctcttct ggcagtacct 601 ggtaggggag cggacgatgc tagctgggca gtgctacatc cagttcctct cccagcccat 661 catcaccttt ggcacagcca tggctgcctt ctacctccct gtcacaguca tgtgcacgct 721 ctactggcgc atctaccggg agacagagaa ccgagcacgg gagctaacag cccttcaggg 781 ctccgagacg ccaggcaaag ggggtggcag cagcagcagc tcagacaggt ctcagccagg 841 ggctgagggc tcaccagaga ctcctccagg ccgctgctgt cgctgctgcc gggcccccag 901 gctgctgcag gcctacagct ggaaggaaga agaggaagag gacgaaggct ccatggagtc 961 cctcacatcc tcagagggaq aggagcctgg ctccgaagtg gtgatcaaga tgccaatggt 1021 ggaccccgag gcacaggccc ccaccaagca gcccccacgg agctccccaa atacagtcaa 1081 gaggccgact aagaaagggc gtgatcgagc tggcaagggc cagaagcccc gtggaaagga 1141 gcagctggcc aagcggaaga ccttctcgct ggtcaaggag aagaaggcgg ctcggaccct 1201 gagtgccatc ctcctggcct tcatcctcac ctggacaccg tacaacatca tggtgctggt 1261 gtccaccttc tgcaaggact gtgttcccga gaccctgtgg gagctgggct actggctgtg 1321 ctacgtcaac agcaccatca accccatgtg ctacgcactc tgcaacaaag ccttccggga 1381 cacctttcgc ctgctgctgc tttgccgctg ggacaagaga cgctggcgca agatccccaa 1441 gcgccctggc tccgtgcacc gcactccctc ccgccaatgc tgatagzccc ctctcctgca 1501 tccctccacc ccagtccccg gg (2) INFORMATION FOR SEQ ID NO:2590: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1561 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (0) TOPOLOGY: linear )xi)SEQUENCE DESCRIPTION: SEQ ID NO: 2590 1 attttaaacc aatgtttata ttatgtttgt taattttatt ctatZcctt gcaggtttaa 61 atgtttattt gccacttggc tactgattag agaacgcaaa atgaataact caacaaactc 121 ctctaacaat agcctggctc ttacaagtcc ttataagaca tttgaagtgg tgtttattgt 181 cctggtggct ggatccctca gtttggtgac cattatcggg aacatzctag tcatggtttc 241 cattaaagtc aaccgccacc tccagaccgt caacaattac tttttatca gcttggcctg 301 tgctgacctt atcataggtg ttttctccat gaacttgtac accctczaca ctgtgattgg 361 ttactggcct ttgggacctg tggtgtgtga cctttggcta gccctagact atgtggtcag 421 caatgcctca ggtatgaatc tgctcatcat cagctttgac aggtactct gtgtcacaaa 481 acctctgacc tacccagtca agcggaccac aaaaatggca ggtataatga ttgcagctgc 541 ctgggtcctc tctttcatcc tctgggctcc agccattctc ttctggcagt tcattgtagg 601 ggtgagaact gtggaggatg gggagtgcta cattcagttt ttttccaatg ctgctgtcac 661 ctttggtacg gctattgcag ccttctattt gccagtgatc atcatgactg tgctatattg 721 gcacatatcc cgagccagca agagcaggat aaagaaggac aagaagagc ctgttgccaa 781 ccaagacccc gtttctccaa gtctggtaca aggaaggata gtgaaaccaa acaataacaa 841.catgcccagc agtgacgatg gcctggagca caacaaaatc cagaatggca aagcccccag 901 ggatcctgtg actgaaaact gtgttcaggg agaggagaag gagagczcca atgactccac 961 ctcagtcagt gcgttgcct ctaatatgag agatgatgaa ataacccagg atgaaaacac 1021 agtttccact tccctgggcc attccaaaga tgagaactct aagcaaacat gcatcagaat 1081 tggcaccaag accccaaaaa gtgactcatg taccccaact aataccaccg tggaggtagt 1141 ggggtcttca ggtcagaatg gagatgaaaa gcagaatatt gtagccgca agattgtgaa 1201 gatgactaag cagcctgcaa aaaagaagcc tcctccttcc cgggaaaaga aagtcaccag 1261 gacaatcttg gctattctgt tggctttcat catcacttgg gccccazaca atgtcatggt 1321 gctcattaac accttttgtg caccttgcat ccccaacact gtgtgaacaa ttggttactg WO 00/09525 PCT/US99/17712 EPI-109 763 1381 gctttgttac atcaacagca ctatcaaccc tgcctgctat gcactttgca atgccacctt 1441 caagaagacc tttaaacacc ttctcatgtg tcattataag aacataggcg ctacaaggta 1501 aaatatcttt gaaaaagata gaaggtgggc aaggggagct tgagaagaat aaaagggata 1561 aacgagctc (2) INFORMATION FOR SEQ ID NO:2591: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1681 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO: 2591 1 tccagtgtac ctccagatga ctcccccatt ccctcctgta gttcatgctt ttctctcccc 61 ttcctcccca gacacggcct acccacccct ggcaaccaac atggccaact tcacacctgt 121 caatggcagc tcgggcaatc agtccgtgcg cctggtcacg tcatcatccc acaatcgcta 181 tgagacggtg gaaatggtct tcattgccac agtgacaggc tccctgagcc tggtgactgt 241 cgtgggcaac atcctggtga tgctgtccat caaggtcaac aggcagctgc agacagtcaa 301 caactacttc ctcttcagcc tggcgtgtgc tgatctcatc ataggcgcct tctccatgaa 361 cctctacacc gtgtacatca tcaagggcta ctggcccctg ggcgccgtgg tctgcgacct 421 gtggctggcc ctggactacg tggtgagcaa cgcctccgtc atgaaccttc tcatcatcag 481 ctttgaccgc tacttctgcg tcaccaagcc tctcacctac cctgcccggc gcaccaccaa 541 gatggcaggc ctcatgattg ctgctgcctg ggtactgtcc ttcgtgctct gggcgcctgc 601 catcttgttc tggcagtttg tggtgggtaa gcggacggtg cccgacaacc agtgcttcat 661 ccagttcctg tccaacccag cagtgacctt tggcacagcc attgctgcct tctacctgcc 721 tgtggtcatc atgacggtgc tgtacatcca catctccctg gccagtcgca gccgagtcca 781 caagcaccgg cccgagggcc cgaaggagaa gaaagccaag acgctggcct tcctcaagag 841 cccactaatg aagcagagcg tcaagaagcc cccgcccggg gaggccgccc gggaggagct 901 gcgcaatggc aagctggagg aggccccccc gccagcgctg ccaccgccac cgcgccccgt 961 ggctgataag gacacttcca atgagtccag ctcaggcagt gccacccaga acaccaagga 1021 acgcccagcc acagagctgt ccaccacaga ggccaccacg cccgccatgc ccgcccctcc 1081 cctgcagccg cgggccctca acccagcctc cagatggtcc aagatccaga ttgtgacgaa 1141 gcagacaggc aatgagtgtg tgacagccat tgagattgtg cctgccacgc cggctggcat 1201 gcgccctgcg gccaacgtgg cccgcaagtt cgccagcatc gctcgcaacc aggtgcgcaa 1261 gaagcggcag atggcggccc gggagcgcaa agtgacacga acgatctttg ccattctgct 1321 agccttcatc ctcacctgga cgccctacaa cgtcatggtc ctggtgaaca ccttctgcca 1381 gagctgcatc cctgacacgq tgtggtccat tggctactgg ctctgctacg tcaacagcac 1441 catcaaccct gcctgctatg ctctgtgcaa cgccaccttt aaaaagacct tccggcacct 1501 gctgctgtgc cagtatcgga acatcggcac tgccaggtag gcaggcagga gtgccctagg 1561 aggtgctggt gttgcgtgcg tgtgctgggg ggaccacacg gctcacttgc tgtggggaag 1621 agttgcaggc accattctgc gttcacgttt gctgaggagg aagttcagaa gaggctctgt 1681 ggctgcattc agagaccaga tct (2) INFORMATION FOR SEQ ID NO:2592: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1861 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO: 2592 1 tcttttaacg tatgtaatgc aaagaacaaa caaataaagg cagaaatttt tctaactctg 61 tctcttctct ctttccccca gactatgtca gagagtcaca atgaccttgc acaataacag 121 tacaacctcg cctttgtttc caaacatcag ctcctcctgg atacacagcc cctccgatgc 181 agggctgccc ccgggaaccg tcactcattt cggcagctac aatgtttctc gagcagctgg 241 caatttctcc tctccagacg gtaccaccga tgaccctctg ggaggtcata ccgtctggca 301 agtggtcttc atcgctttct taacgggcat cctggccttg gtgaccatca tcggcaacat 361 cctggtaatt gtgtcattta aggtcaacaa gcagctgaag acggtcaaca actacttcct 421 cttaagcctg gcctgtgccg atctgattat cggggtcatt tcaatgaatc tgtttacgac 481 ctacatcatc atgaatcgat gggccttagg gaacttggcc tgtgacctct ggcttgccat 541 tgactacgta gccagcaatg cctctgttat gaatcttctg gtcatcagct ttgacagata 601 cttttccatc acgaggccgc tcacgtaccg agccaaacga acaacaaaga gagccggtgt 661.gatgatcggt ctggcttggg tcatctcctt tgtcctttgg gctcctgcca tcttgttctg 721 gcaatacttt gttggaaaga gaactgtgcc tccgggagag tgcttcattc agttcctcag 781 tgagcccacc attacttttg gcacagccat cgctgctttt tatatgcctg tcaccattat 841 gactatttta tactggagga tctataagga aactgaaaag cgtaccaaag agcttgctgg 901 cctgcaagcc tctgggacag aggcagagac agaaaacttt gtccacccca cgggcagttc 961 tcgaagctgc agcagttacg aacttcaaca gcaaagcatg aaacgctcca acaggaggaa 1021 gtatggccgc tgccacttct ggttcacaac caagagctgg aaacccagct ccgagcagat 1081 ggaccaagac cacagcagca gtgacagttg gaacaacaat gatgctgctg cctccctgga 1141 gaactccgcc tcctccgacg aggaggacat tggctccgag acgagagcca tctactccat WO 00/09525 PCTIUS99/17712 EPI-109 764 1201 cgtgctcaag cttccgggtc acagcaccat cctcaactcc accaagttac cctcatcgga 1261 caacctgcag gtgcctgagg aggagctggg gatggtggac ttggagagga aagccgacaa 1321 gctgcaggcc cagaagagcg tggacgatgg aggcagtttt ccaaaaagct tctccaagct 1381 tcccatccag ctagagtcag ccgtggacac agctaagact tctgacgtca actcctcagt 1441 gggtaagagc acggccactc tacctctgtc cttcaaggaa gccactctgg ccaagaggtt 1501 tgctctgaag accagaagtc agatcactaa gcggaaaagg atgtccctgg tcaaggagaa 1561 gaaagcggcc cagaccctca gtgcgatctt gcttgccttc atcatcactt ggaccccata 1621 caacatcatg gttctggtga acaccttttg tgacagctgc atacccaaaa ccttttggaa 1681 tctgggctac tggctgtgct acatcaacag caccgtgaac cccgtgtgct atgctctgtg 1741 caacaaaaca ttcagaacca ctttcaagat gctgctgctg tgccagtgtg acaaaaaaaa 1801 gaggcgcaag cagcagtacc agcagagaca gtcggtcatt tttcacaagc gcgcacccga 1861 gcaggccttg tagaatgagg ttgtatcaat agcagtgaca aaacgacaca tca (2) INFORMATION FOR SEQ ID NO:2593: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 6604 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO: 2593 1 agcccatgtc ctctcttttc aggtgatgac tttcccctga ggaagccctg tagcgtgcct 61 ggaggaaggg gctctccaac cccagcccca cctagccacc atgaacactt cagccccacc 121 tgctgtcagc cccaacatca ccgtcctggc accaggaaag ggtccctggc aagtggcctt 181 cattgggatc accacgggcc tcctgtcgct agccacagtg acaggcaacc tgctggtact 241 catctctttc aaggtcaaca cggagctcaa gacagtcaat aactacttcc tgctgagcct 301 ggcctgtgct gacctcatca tcggtacctt ctccatgaac ctctatacca cgtacctgct 361 catgggccac tgggctctgg gcacgctggc ttgtgacctc tggctggccc tggactatgt 421 ggccagcaat gcctccgtca tgaatctgct gctcatcagc tttgaccgct acttctccgt 481 gactcggccc ctgagctacc gtgccaagcg cacaccccgc cgggcagctc tgatgatcgg 541 cctggcctgg ctggtttcct ttgtgctctg ggccccagcc atcctcttct ggcagtacct 601 ggtaggggag cggacgatgc tagctgggca gtgctacatc cagttcctct cccagcccat 661 catcaccttt ggcacagcca tggctgcctt ctacctccct gtcacagtca tgtgcacgct 721 ctactggcgc atctaccggg agacagagaa ccgagcacgg gagctggcag cccttcaggg 781 ctccgagacg ccaggcaaag ggggtggcag cagcagcagc tcagagaggt ctcagccagg 841 ggctgagggc tcaccagaga ctcctccagg ccgctgctgt cgctgctgcc gggcccccag 901 gctgctgcag gcctacagct ggaaggaaga agaggaagag gacgaaggct ccatggagtc 961 cctcacatcc tcagagggag aggagcctgg ctccgaagtg gtgatcaaga tgccaatggt 1021 ggaccccgag gcacaggccc ccaccaagca gcccccacgg agctccccaa atacagtcaa 1081 gaggccgact aagaaagggc gtgatcgagc tggcaagggc cagaagcccc gtggaaagga 1141 gcagctggcc aagcggaaga ccttctcgct ggtcaaggag aagaaggcgg ctcggaccct 1201 gagtgccatc ctcctggcct tcatcctcac ctggacaccg tacaacatca tggtgctggt 1261 gtccaccttc tgcaaggact gtgttcccga gaccctgtgg gagctgggct actggctgtg 1321 ctacgtcaac agcaccatca accccatgtg ctacgcactc tgcaacaaag ccttccggga 1381 cacctttcgc ctgctgctgc tttgccgctg ggacaagaga cgctggcgca agatccccaa 1441 gcgccctggc tccgtgcacc gcactccctc ccgccaatgc tgatagtccc ctctcctgca 1501 tccctccacc ccagtccccg gg 1 attttaaacc aatgtttata ttatgtttgt taattttatt ctatttcctt gcaggtttaa 61 atgtttattt gctacttggc tactgattag agaacgcaaa atgaataact caacaaactc 121 ctctaacaat agcctggctc ttacaagtcc ttataagaca tttgaagtgg tgtttattgt 181 cctggtggct ggatccctca gtttggtgac cattatcggg aacatcctag tcatggtttc 241 cattaaagtc aaccgccacc tccagaccgt caacaattac tttttattca gcttggcctg 301 tgctgacctt atcataggtg ttttctccat gaacttgtac accctctaca ctgtgattgg 361 ttactggcct ttgggacctg tggtgtgtga cctttggcta gccctggact atgtggtcag 421 caatgcctca gttatgaatc tgctcatcat cagctttgac aggtacttct gtgtcacaaa 481 acctctgacc tacccagtca agcggaccac aaaaatggca ggtatgatga ttgcagctgc 541 ctgggtcctc tctttcatcc tctgggctcc agccattctc ttctggcagt tcattgtagg 601 ggtgagaact gtggaggatg gggagtgcta cattcagttt ttttccaatg ctgctgtcac 661 ctttggtacg gctattgcag ccttctattt gccagtgatc atcatgactg tgctatattg 721 gcacatatcc cgagccagca agagcaggat aaagaaggac aagaaggagc ctgttgccaa 781 ccaagacccc gtttctccaa gtctggtaca aggaaggata gtgaagccaa acaataacaa 841 catgcccagc agtgacgatg gcctggagca caacaaaatc cagaatggca aagcccccag 901 ggatcctgtg actgaaaact gtgttcaggg agaggagaag gagagctcca atgactccac 961 ctcagtcagt gctgttgcct ctaatatgag agatgatgaa ataacccagg atgaaaacac 1021 agtttccact tccctgggcc attccaaaga tgagaactct aagcaaacat gcatcagaat 1081 tggcaccaag accccaaaaa gtgactcatg taccccaact aataccaccg tggaggtagt 1141 ggggtcttca ggtcagaatg gagatgaaaa gcagaatatt gtagcccgca agattgtgaa 1201 gatgactaag cagcctgcaa aaaagaagcc tcctccttcc cgggaaaaga aagtcaccag 1261 gacaatcttg gctattctgt tggctttcat catcacttgg gccccataca atgtcatggt 1321 gctcattaac accttttgtg caccttgcat ccccaacact gtgtggacaa ttggttactg WO 00/09525 PCT/US99/17712 EPI-109 765 1381 gctttgttac atcaacagca ctatcaaccc tgcctgctat gcacttzgca atgccacctt 1441 caagaagacc tttaaacacc ttctcatgtg tcattataag aacataggcg ctacaaggta 1501 aaatatcttt gaaaaagata gaaggtgggc aaggggagct tgagaagaat aaaagggata 1561 aacgagctc 1 tccagtgtac ctccagatga ctcccccatt ccctcctgta gttcatgctt ttctctcccc 61 ttcctcccca gacacggcct acccacccct ggcaaccaac atggccaact tcacacctgt 121 caatggcagc tcgggcaacc agtccgtgcg cctggtcacg tcatcatccc acaatcgcta 181 tgagacggtg gaaatggtct tcattgccac agtgacaggc tccctgagcc tggtgactgt 241 cgtgggcaac atcctggtga tgctgtccat caaggtcaac aggcaactgc agacagtcaa 301 caactacttc ctcttcagcc tggcgtgtgc tgatctcatc ataggcgcct tctccatgaa 361 cctctacacc gtgtacatca tcaagggcta ctggcccctg ggcgccgtgg tctgcgacct 421 gtggctggcc ctggactacg tggtgagcaa cgcctccgtc atgaaccttc tcatcatcag 481 ctttgaccgc tacttctgcg tcaccaagcc tctcacctac cctgcccggc gcaccaccaa 541 gatggcaggc ctcatgattg ctgctgcctg ggtactgtcc ttcgtgctct gggcgcctgc 601 catcttgttc tggcagtttg tggtgggtaa gcggacggtg cccgacaacc agtgcttcat 661 ccagttcctg tccaacccag cagtgacctt tggcacagcc attgctgcct tctacctgcc 721 tgtggtcatc atgacggtgc tgtacatcca catctccctg gccagtcgca gccgagtcca 781 caagcaccgg cccgagggcc cgaaggagaa gaaagccaag acgctggcct tcctcaagag 841 cccactaatg aagcagagcg tcaagaagcc cccgcccggg gaggccgccc gggaggagct 901 gcgcaatggc aagctggagg aggccccccc gccagcgctg ccaccgccac cgcgccccgt 961 ggctgataag gacacttcca atgagtccag ctcaggcagt gccacccaga acaccaagga 1021 acgcccagcc acagagctgt ccaccacaga ggccaccacg cccgccatgc ccgcccctcc 1081 cctgcagccg cgggccctca acccagcctc cagatggtcc aagatccaga ttgtgacgaa 1141 gcagacaggc aatgagtgtg tgacagccat tgagattgtg cctgccacgc cggctggcat 1201 gcgccctgcg gccaacgtgg cccgcaagtt cgccagcatc gctcgcaacc aggtgcgcaa 1261 gaagcggcag atggcggccc gggagcgcaa agtgacacga acgatctttg ccattctgct 1321 agccttcatc ctcacctgga cgccctacaa cgtcatggtc ctggtgaaca ccttctgcca 1381 gagctgcatc cctgacacgg tgtggtccat tggctactgg ctctgctacg tcaacagcac 1441 catcaaccct gcctgctatg ctctgtgcaa cgccaccttt aaaaagacct tccggcacct 1501 gctgctgtgc cagtatcgga acatcggcac tgccaggtag gcaggcagga gtgccctagg 1561 aggtgctggt gttgcgtgcg tgtgctgggg ggaccacacg gctcacttgc tgtggggaag 1621 agttgcaggc accattctgc gttcacgttt gctgaggagg aagttcagaa gaggctctgt 1681 ggctgcattc agagaccaga tct 1 tcttttaacg tatgtaatgc aaagaacaaa caaataaagg cagaaatttt tctaactctg 61 tctcttctct ctttccccca gactatgtca gagagtcaca atgaccttgc acaataacag 121 tacaacctcg cctttgtttc caaacatcag ctcctcctgg atacacagcc cctccgatgc 181 agggctgccc ccgggaaccg tcactcattt cggcagctac aatgtttctc gagcagctgg 241 caatttctcc tctccagacg gtaccaccga tgaccctctg ggaggtcata ccgtctggca 301 agtggtcttc atcgctttct taacgggcat cctggccttg gtgaccatca tcggcaacat 361 cctggtaatt gtgtcattta aggtcaacaa gcagctgaag acggtcaaca actacttcct 421 cttaagcctg gcctgtgccg atctgattat cggggtcatt tcaatgaatc tgtttacgac 481 ctacatcatc atgaatcgat gggccttagg gaacttggcc tgtgacctct ggcttgccat 541 tgactacgta gccagcaatg cctctgttat gaatcttctg gtcatcagct ttgacagata 601 cttttccatc acgaggccgc tcacgtaccg agccaaacga acaacaaaga gagccggtgt 661 gatgatcggt ctggcttggg tcatctcctt tgtcctttgg gctcctgcca tcttgttctg 721 gcaatacttt gttggaaaga gaactgtgcc tccgggagag tgcttcattc agttcctcag 781 tgagcccacc attacttttg gcacagccat cgctgctttt tatatgcctg tcaccattat 841 gactatttta tactggagga tctataagga aactgaaaag cgtaccaaag agcttgctgg 901 cctgcaagcc tctgggacag aggcagagac agaaaacttt gtccacccca cgggcagttc 961 tcgaagctgc agcagttacg aacttcaaca gcaaagcatg aaacgctcca acaggaggaa 1021 gtatggccgc tgccacttct ggttcacaac caagagctgg aaacccagct ccgagcagat 1081 ggaccaagac cacagcagca gtgacagttg gaacaacaat gatgctgctg cctccctgga 1141 gaactccgcc tcctccgacg aggaggacat tggctccgag acgagagcca tctactccat 1201 cgtgctcaag cttccgggtc acagcaccat cctcaactcc accaagttac cctcatcgga 1261 caacctgcag gtgcctgagg aggagctggg gatggtggac ttggagagga aagccgacaa 1321 gctgcaggcc cagaagagcg tggacgatgg aggcagtttt ccaaaaagct tctccaagct 1381 tcccatccag ctagagtcag ccgtggacac agctaagact tctgacgtca actcctcagt 1441 gggtaagagc acggccactc tacctctgtc cttcaaggaa gccactctgg ccaagaggtt 1501 tgctctgaag accagaagtc agatcactaa gcggaaaagg atgtccctgg tcaaggagaa 1561 gaaagcggcc cagaccctca gtgcgatctt gcttgccttc atcatcactt ggaccccata 1621 caacatcatg gttctggtga acaccttttg tgacagctgc atacccaaaa ccttttggaa 1681 tctgggctac tggctgtgct acatcaacag caccgtgaac cccgtatgct atgctctgtg 1741 caacaaaaca ttcagaacca ctttcaagat gctgctgctg tgccagtgtg acaaaaaaaa 1801 gaggcgcaag cagcagtacc agcagagaca gtcggtcatt tttcacaagc gcgcacccga 1861 gcaggccttg tagaatgagg ttgtatcaat agcagtgaca aaacgacaca tca (2) INFORMATION FOP. SEQ ID NO:2594: WO 00/09525 PCT/US99/17712 EPI-109 766 (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1201 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO: 2594 1 atggataacg tcctcccggt ggactcagac ctctccccaa acatctccac taacacctcg 61 gaacccaatc agttcgtgca accagcctgg caaattgtcc tttgggcagc tgcttacacg 121 gtcattgtgg tgacctctgt ggtgggcaac gtggtagtga tgtggatcat cttagcccac 181 aaaagaatga ggacagtgac gaactatttt ctggtgaacc tggccttcgc ggaggcctcc 241 atggctgcat tcaatacagt ggtgaacttc acctatgctg tccacaacga atggtactac 301 ggcctgttct actgcaagtt ccacaacttc ttccccatcg ccgcttgctt cgccagtatc 361 tactccatga cggctgtggc ctttgatagg tacatggcca tcatacatcc cctccagccc 421 cggctgtcag ccacagccac caaagtggtc atctgtgtca tctgggtcct ggctctcctg 481 ctggccttcc cccagggcta ctactcaacc acagagacca tgcccagcag agtcgtgtgc 541 atgatcgaat ggccagagca tccgaacaag atttatgaga aagtgtacca catctgtgtg 601 actgtgctga tctacttcct ccccctgctg gtgattggct atgcatacac catagtggga 661 atcacactat gggccagtga gatccccggg gactcctctg accgctacca cgagcaagtc 721 tctgccaagc gcaaggtggt caaaatgatg attgtcgtgg tgtgcacctt cgccatctgc 781 tggctgccct tccacatct. cttcctcctg ccctacatca acccagatct ctacctgaag 841 aagtttatcc agcaggtcta cctggccatc atgtggctgg ccatgagctc caccatgtac 901 aaccccatca tctactgctg cctcaatgac aggttccgtc tgggcttcaa gcatgccttc 961 cggtgctgcc ccttcatcag cgccggcgac tatgaggggc tggaaatgaa atccacccgg 1021 tatctccaga cccagggcag tgtgtacaaa gtcagccgcc tggagaccac catctccaca 1081 gtggtggggg cccacgagga ggagccagag gacggcccca aggccacacc ctcgtccctg 1141 gacctgacct ccaactgctc ttcacgaagt gactccaaga ccatgacaga gagcttcagc 1201 ttctcctcca atgtgctctc ctagggatcc (2) INFORMATION FOR SEQ ID NO:2595: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1741 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2595 1 ctattgcagt atctttcagc ttccagtctt atctgaagac cccggcacca aagtgaccag 61 gaggcagaga agaacttcag aggagtctcg tcttgggctg cccgtgggtg agtgggaggg 121 tccgggactg cagaccggtg gcgatggcca ctctcccagc agcagaaacc tggatagacg 181 ggggtggagg cgtgggtgca gacgccgtga acctgaccgc ctcgctagct gccggggcgg 241 ccacgggggc agttgagact gggtggctgc aactgctgga ccaagctggc aacctctcct 301 cctccccttc cgcgctggga ctgcctgtgg cttcccccgc gccctcccag ccctgggcca 361 acctcaccaa ccagttcgtg cagccgtcct ggcgcatcgc gctctggtcc ctggcgtatg 421 gtgtggtggt ggcagtggca gttttgggaa atctcatcgt catctggatc atcctggccc 481 acaagcgcat gaggactgtc accaactact tccttgtgaa cctggctttc tccgacgcct 541 ccatggccgc cttcaacacg ttggtcaatt tcatctacgc gcttcatagc gagtggtact 601 ttggcgccaa ctactgccgc: ttccagaact tctttcctat cacagctgtg ttcgccagca 661 tctactccat gacggccatt gcggtggaca ggtatatggc tattattgat cccttgaaac 721 ccagactgtc tgctacagca accaagattg tcattggaag tatttggatt ctagcatttc 781 tacttgcctt ccctcagtgt ctttattcca aaaccaaagt catgccaggc cgtactctct 841 gctttgtgca atggccagaa ggtcccaaac aacatttcac ttaccatatt atcgtcatta 901 tactggtgta ctgtttccca ttgctcatca tgggtattac atacaccatt gttggaatta 961 ctctctgggg aggagaaatc ccaggagata cctgtgacaa gtatcatgag cagctaaagg 1021 ccaaaagaaa ggttgtcaaa atgatgatta ttgttgtcat gacatttgct atctgctggc 1081 tgccctatca tatttacttc attctcactg caatctatca acaactaaat agatggaaat 1141 acatccagca ggtctacctg gctagctttt ggctggcaat gagctcaacc atgtacaatc 1201 ccatcatcta ctgctgtctg aataaaagat ttcgagctgg cttcaagaga gcatttcgct 1261 ggtgtccttt catcaaagtt tccagctatg atgagctaga gctcaagacc accaggtttc 1321 atccaaaccg gcaaagcagt atgtacaccg tgaccagaat ggagtccatg acagtcgtgt 1381 ttgaccccaa cgatgcagac accaccaggt ccagtcggaa gaaaagagca acgccaagag 1441 acccaagttt caatggctgc tctcgcagga attccaaatc tgcctccgcc acttcaagtt 1501 tcataagctc accctatacc tctgtggatg aatattctta attccatttc ctgaggtaaa 1561 agattagtgt gagaccatca tggtgccagt ctaggacccc attctcctat ttatcagtcc 1621 tgtcctatat accctctaga aacagaaagc aatttttagg cagctatggt caaattgaga 1681 aaggtagtgt ataaatgtga caaagacact aataacatgt tagcctccac ccaaaataaa 1741 atgggcttta aattt (2) INFORMATION FOR SEQ ID NO:2596: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1141 base pairs (B) TYPE: nucleic acid WO 00/09525 PCT/US99/17712 EPI-109 767 (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO: 2596 1 atggggacct gtgacattgt gactgaagcc aatatctcat ctggccctga gagcaacacc 61 acgggcatca cagcctrctc catgcccagc tggcagctgg cactgtgggc accagcctac 121 ctggccctgg tgctggzggc cgtgacgggt aatgccatcg tcatctggat catcctggcc 181 catcggagga tgcgcacagt caccaactac ttcatcgtca atctggcgct ggctgacctc 241 tgcatggctg ccttcaatgc cgccttcaac tttgtctatg ccagccacaa catctggtac 301 tttggccgtg ccttctacta cttccagaac ctcttcccca tcacagccat gtttgtcagc 361 atctactcca tgaccaccat tgctgccgac aggtacatgg ccatcgtcca ccccttccag 421 cctcggcttt cagctcccag caccaaggcg gttattgctg gcatctggct ggtggctctc 481 gccctggcct cccctcagtg cttctactcc accgtcacca tggaccaggg tgccaccaag 541 tgcgtggtgg cctggcccga agacagcggg ggcaagacgc tcctcctgta ccacctcgtg 601 gtgatcgccc tcatctactt cctgccgctc gcggtgatgt ttgtagccta cagcgtcatc 661 ggcctcacgc tctggaggcg cgcagtgccc ggacatcagg cgcacggtgc caacctccgc 721 catctgcagg ccaagaagaa gtttgtgaag accatggtgc tggtggtgct gacgtttgcc 781 atctgctggc tgccctacca cctctacttc atcctgggca gcttccagga ggacatctac 841 tgccacaagt tcatccagca agtctacctg gcactcttct ggttggccat gagctctacc 901 atgtacaatc ccatcarcta ctgctgtctc aaccacaggt ttcgctctgg gttccggctt 961 gccttccgct gctgcccatg ggtcacaccc accaaggaag ataagctcga gctgactccc 1021 acgacctccc tctccacgag agtcaacagg tgtcacacta aggagacttt gttcatggct 1081 ggggacacag ccccctccga ggctaccagt ggggaggcgg ggcgtcccca ggatggatca 1141 gggctatggt ttgggtatgg tttgcttgcc cccaccaaaa ctcatgttga aatttga (2) INFORMATION FOR SEQ ID NO:2597: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 4083 base pairs (B) TYPE: nucleic aci d (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO: 2597 1 atggataacg tcctcccggt ggactcagac ctctccccaa acatctccac taacacctcg 61 gaacccaatc agttcgtgca accagcctgg caaattgtcc tttgggcagc tgcttacacg 121 gtcattgtgg tgacctctgt ggtgggcaac gtggtagtga tgtggatcat cttagcccac 181 aaaagaatga ggacagtgac gaactatttt ctggtgaacc tggccttcgc ggaggcctcc 241 atggctgcat tcaatacagt ggtgaacttc acctatgctg tccacaacga atggtactac 301 ggcctgttct actgcaagtt ccacaacttc ttccccatcg ccgcttgctt cgccagtatc 361 tactccatga cggctgtggc ctttgatagg tacatggcca tcatacatcc cctccagccc 421 cggctgtcag ccacagccac caaagtggtc atctgtgtca tctgggtcct ggctctcctg 481 ctggccttcc cccagggcta ctactcaacc acagagacca tgcccagcag agtcgtgtgc 541 atgatcgaat ggccagagca tccgaacaag atttatgaga aagtgtacca catctgtgtg 601 actgtgctga tctacttcct ccccctgctg gtgattggct atgcatacac catagtggga 661 atcacactat gggccagtga gatccccggg gactcctctg accgctacca cgagcaagtc 721 tctgccaagc gcaaggtggt caaaatgatg attgtcgtgg tgtgcacctt cgccatctgc 781 tggctgccct tccacatctt cttcctcctg ccctacatca acccagatct ctacctgaag 841 aagtttatcc agcaggca cctggccatc atgtggctgg ccatgagctc caccatgtac 901 aaccccatca tctactgctg cctcaatgac aggttccgtc tgggcttcaa gcatgccttc 961 cggtgctgcc ccttcatcag cgccggcgac tatgaggggc tggaaatgaa atccacccgg 1021 tatctccaga cccagggcag tgtgtacaaa gtcagccgcc tggagaccac catctccaca 1081 gtggtggggg cccacgagga ggagccagag gacggcccca aggccacacc ctcgtccctg 1141 gacctgacct ccaactgctc ttcacgaagt gactccaaga ccatgacaga gagcttcagc 1201 ttctcctcca atgtgctctc ctagggatcc 1 ctattgcagt atctttcagc ttccagtctt atctgaagac cccggcacca aagtgaccag 61 gaggcagaga agaacttcag aggagtctcg tcttgggctg cccgtgggtg agtgggaggg 121 tccgggactg cagaccggtg gcgatggcca ctctcccagc agcagaaacc tggatagacg 181 ggggtggagg cgtgggtgca gacgccgtga acctgaccgc ctcgctagct gccggggcgg 241 ccacgggggc agttgagact gggtggctgc aactgctgga ccaagctggc aacctctcct 301 cctccccttc cgcgctggga ctgcctgtgg cttcccccgc gccctcccag ccctgggcca 361 acctcaccaa ccagttcgtg cagccgtcct ggcgcatcgc gctctggtcc ctggcgtatg 421 gtgtggtggt ggcagtggca gttttgggaa atctcatcgt catctggatc atcctggccc 481 acaagcgcat gaggactgtc accaactact tccttgtgaa cctggctttc tccgacgcct 541 ccatggccgc cttcaacacg ttggtcaatt tcatctacgc gcttcatagc gagtggtact 601 ttggcgccaa ctactgccgc ttccagaact tctttcctat cacagctgtg ttcgccagca 661 tctactccat gacggccatt gcggtggaca ggtatatggc tattattgat cccttgaaac 721 ccagactgtc tgctacagca accaagattg tcattggaag tatttggatt ctagcatttc 781 tacttgcctt ccctcagtgt ctttattcca aaaccaaagt catgccaggc cgtactctct 841 gctttgtgca atggccagaa ggtcccaaac aacatttcac ttaccatatt atcgtcatta 901 tactggtgta ctgttccca ttgctcatca tgggtattac atacaccatt gttggaatta 961 ctctctgggg aggagaaatc ccaggagata cctgtgacaa gtatcatgag cagctaaagg WO 00/09525 PCT/US99/17712 EPI-109 768 1021 ccaaaagaaa ggttgtcaaa atgatgatta ttgttgtcat gacatttgct atctgctggc 1081 tgccctatca tatttacttc attctcactg caatctatca acaactaaat agatggaaat 1141 acatccagca ggtctacctg gctagctttt ggctggcaat gagctcaacc atgtacaatc 1201 ccatcatcta ctgctgtctg aataaaagat ttcgagctgg cttcaagaga gcatttcgct 1261 ggtgtccttt catcaaagtt tccagctatg atgagctaga gctcaagacc accaggtttc 1321 atccaaaccg gcaaagcagt atgtacaccg tgaccagaat ggagtccatg acagtcgtgt 1381 ttgaccccaa cgatgcagac accaccaggt ccagtcggaa gaaaagagca acgccaagag 1441 acccaagttt caatggctgc tctcgcagga attccaaatc tgcctccgcc acttcaagtt 1501 tcataagctc accctatacc tctgtggatg aatattctta attccatttc ctgaggtaaa 1561 agattagtgt gagaccatca tggtgccagt ctaggacccc attctcctat ttatcagtcc 1621 tgtcctatat accctctaga aacagaaagc aatttttagg cagctatggt caaattgaga 1681 aaggtagtgt ataaatgtga caaagacact aataacatgt tagcctccac ccaaaataaa 1741 atgggcttta aattt 1 atggggacct gtgacattgt gactgaagcc aatatctcat ctggccctga gagcaacacc 61 acgggcatca cagccttctc catgcccagc tggcagctgg cactgtgggc accagcctac 121 ctggccctgg tgctggtggc cgtgacgggt aatgccatcg tcatczggat catcctggcc 181 catcggagga tgcgcacagt caccaactac ttcatcgtca atctggcgct ggctgacctc 241 tgcatggctg ccttcaatgc cgccttcaac tttgtctatg ccagccacaa catctggtac 301 tttggccgtg ccttctgcta cttccagaac ctcttcccca tcacagccat gtttgtcagc 361 atctactcca tgaccgccat tgctgccgac aggtacatgg ccatcgtcca ccccttccag 421 cctcggcttt cagctcccag caccaaggcg gttattgctg gcatctggct ggtggctctc 481 gccctggcct cccctcagtg cttctactcc accgtcacca tggaccaggg tgccaccaag 541 tgcgtggtgg cctggcccga agacagcggg ggcaagacgc tcctcctgta ccacctcgtg 601 gtgatcgccc tcatctactt cctgccgctc gcggtgatgt ttgtagccta cagcgtcatc 661 ggcctcacgc tctggaggcg cgcagtgccc ggacatcagg cgcacggtgc caacctccgc 721 catctgcagg ccaagaagaa gtttgtgaag accatggtgc tggtggtgct gacgtttgcc 781 atctgctggc tgccctacca cctctacttc atcctgggca gcttccagga ggacatctac 841 tgccacaagt tcatccagca agtctacctg gcactcttct ggttggccat gagctctacc 901 atgtacaatc ccatcatcta ctgctgtctc aaccacaggt ttcgctctgg gttccggctt 961 gccttccgct gctgcccatg ggtcacaccc accaaggaag ataagctcga gctgactccc 1021 acgacctccc tctccacgag agtcaacagg tgtcacacta aggagacttt gttcatggct 1081 ggggacacag ccccctccga ggctaccagt ggggaggcgg ggcgtcccca ggatggatca 1141 gggctatggt ttgggtatgg tttgcttgcc cccaccaaaa ctcatgttga aatttga (2) INFORMATION FOR SEQ ID NO:2598: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1501 base pairs (B) TYPE: nucleic acid (C) STRAINDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO: 2598 1 ctccataagg cacaaacttt cagagacagc agagcacaca agcttctagg acaagagcca 61 ggaagaaacc accggaagga accatctcac tgtgtgtaaa catgacttcc aagctggccg 121 tggctctctt ggcagccttc ctgatttctg cagctctgtg tgaaggtgca gttttgccaa 181 ggagtgctaa agaacttaga tgtcagtgca taaagacata ctccaaacct ttccacccca 241 aatttatcaa agaactgaga gtgattgaga gtggaccaca ctgcgccaac acagaaatta 301 ttgtaaagct ttctgatgga agagagctct gtctggaccc caaggaaaac tgggtgcaga 361 gggttgtgga gaagtttttg aagagggctg agaattcata aaaaaattca ttctctgtgg 421 tatccaagaa tcagtgaaga tgccagtgaa acttcaagca aatctacttc aacacttcat 481 gtattgtgtg ggtctgtcgt agggttgcca gatgcaatac aagattcctg gttaaatttg 541 aatttcagta aacaatgaat agtttttcat tgtaccatga aatatccaga acatacttat 601 atgtaaagta ttatttattt gaatctacaa aaaacaacaa ataattttta aatataagga 661 ttttcctaga tattgcacgg gagaatatac aaatagcaaa attgggccaa gggccaagag 721 aatatccgaa ctttaatttc aggaattgaa tgggtttgct agaatgtgat atttgaagca 781 tcacataaaa atgatgggac aataaatttt gccataaagt caaatttagc tggaaatcct 841 ggattttttt ctgttaaatc tggcaaccct agtcagctag ccaggatcca caagtccttg 901 ttccactgtg ccttggtttc tcctttattt ctaagtggaa aaagtattag ccaccatctt 961 acctcacagt gatgttgtga ggacatgtgg aagcacttta agttttttca tcataacata 1021 aattattttc aagtgtaact tattaaccta tttattattt atgtatttat ttaagcatca 1081 aatatttgtg caagaatttg gaaaaataga agatgaatca ttgattgaat agttataaag 1141 atgttatagt aaatttattt tattttagat attaaatgat gtcttattag ataaatttca 1201 atcagggttt ttagattaaa caaacaaaca attgggtacc cagttaaatt ttcatttcag 1261 atatacaaca aataattttt tagtataagt acattattgt ttatctgaaa ttttaattga 1321 actaacaatc ctagtttgat actcccagtc ttgtcattgc cagctgtgtt ggtagtgctg 1381 tgttgaatta cggaataatg agttagaact attaaaacag ccaaaactcc acagtcaata 1441 ttagtaattt cttgctggtt gaaacttgtt tattatgtac aaatagactc ttataatatt 1501 atttaaatga ctgcattttt aaatacaagg ctttatattt ttaactttaa aaaaaaccgg WO 00/09525 PCTIUS99/17712 EPI-109 769 (2) INFORMATION FOR SEQ ID NO:2599: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1561 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO: 2599 1 gaattctctc tccagcagcc ctgccagatg cccgcccagc ccctgcctca ggcggggagg 61 gcttcaggga agctcaccaa ggcagaaggg cgggagagat tgtcagagcc ccagctggtg 121 tccagggact gaccgtgagc ctgggtgaaa gtgagttccc cgttggaggc aacagacgag 181 gagaggatgg aaggcctggc ccccaagaat gagccctgag gttcagggag cggctggagt 241 gagccggccc cagatctccg tccagctgcg ggtcccagag gcctgcccta cactcgcagc 301 tcctggggga ggcccttgac gtgcctcagt tcccaaacag gaaccczggg aaggaccaga 361 gaagtgccta ttgcgcagtg agtgcccgac acagctgcat gtggccagta tcacagggcc 421 ctgggtaaac tgaggcaggc gacacagctg catgtggccg gtatcacagg gccctgggta 481 aactgaggca ggcgacacag ctgcatgtgg ccggtatcac agggccctgg gtaaactgag 541 gcaggcgaca cagctgcatg tggccgtatc acagggccct gggtaaactg aggcaggtga 601 cacagctgca tgtggccggt atcacggggc cctggataaa cagaggcagg cgacacagct 661 gcatgtggcc ggtatcacgg ggccctgggt aaactgaggc aggcgaggcc acccccatca 721 agtccctcag gtctaggttt ggcaggtttg gcaaaaacac agcaacgctc ggttaaatct 781 gaatttcggg taagtatatc ctgggcctca tttggaagag acttagatta aaaaaaaaac 841 gtcgagacca gcccggccaa cacggtgaaa ccccgtctct actaaaaata caaaaaatta 901 gccaggcgca gtggctcacg cctgtgatcc cagcactctg ggaggctgag gcaggcggat 961 cacccgaggt cagatgttca agaccagcct ggccgacagg gcgaaacact gtctctacta 1021 caaatacaaa aattagccgg gagtggtggc aggtgcctgt aatctcagct attcaggagg 1081 ctgaggcagg agaatcactt gaacctggga ggcggaggtt gccgtgagcc gggatcacgc 1141 caccgcactc cagcctgggc gatagagcaa gactctgtct ccaaaaaaat aaattaaaaa 1201 acccacattg attatctgac atttgaatgc gattgtgcat cctgaatttt gtctggaggc 1261 cccacccgag ccaatccagc gtcttgtccc ccttctcccc cttttcatca acgccctgtg 1321 ccaggggaga ggaagtggag ggcgctggcc ggccgtgggg caatgcaacg gcctcccagc 1381 acagggctat aagaggagcc gggcgggcac ggaggggcag agaccccgga gccccagccc 1441 caccatgacc ctcggccgcc gactcgcgtg tcttttcctc gcctgtgtcc tgccggcctt 1501 gctgctgggg ggtgagtttt tgagtccaac ctcccgctgc tccctctgtc ccgggttctg 1561 t (2) INFORMATION FOR SEQ ID NO:2600: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 5101 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO: 2600 1 agcttcatcc tggagtcaac agattgggtt tgaatcctgg ctctgtccct ttctagctgt 61 gtgtttggtt gttactccac ctctctgagc cttaatttct tcatcagtaa aagtaatatt 121 cacctcctag ggttgttggg agggagaata agaacttcta aagtacccga acctagcaac 181 taggacacta tatttgcagg caagatgaag aggggtgggg aagtaatagg aaacagccca 241 aatcgagagc cataatagtc tctctttact tagtgccagt gcaggcctgt gattctgttc 301 ttaaaaacgt ctggggcaag ctgcaggaaa gacccgagat agcttatgtt ctaccataag 361 ccttaaggga ggaggactcc aggcagggag acttaccatg gcacctctaa gagaaagcct 421 actgaccaga gagaggtcag tcatgtactc ccgtagcttc ttagaatttc tgatctgact 481 cgctgcctct agagttgttc aggtggaaat tggaaggcta tagaggaatt cggcagcata 541 cagtggctca cgtctgtaat ccaaaatcca agcattttgg aaggccaaag taggaggatc 601 acttaagccc aggagtttaa gaccagccta ggcaaccgag tgagatccat ctccactaaa 661 aaattttaaa atttgccagg tatggtggtg tgcacctgta gccccagcta ctcaggagag 721 tcagagaatc ggcgcacccc ggagttcgag gttgcagtga gccatgatca cgccactgta 781 ctccagcctg ggtgacagag aagaccacct gtctcaaaaa acataaataa ataaataaat 841 aaataggccg tgcgcagcgg ctcacgactg taattccaac attttagaag gcggaggcag 901 cggatcacct gaggtcagga gtacgggacc agcctgacca acgtggtgaa accccaactc 961 tactaaaaat acataaatta ggcggggcgt ggtggtggcc gcctgtaatc ccagctactc 1021 ggtaggctgc agcaggagaa tggtttgaac ccgggaggca gaggtzgcag tgagccaaaa 1081 tcccctcact gcattccagc ctgagactaa aaaaaagagg cgatttccca catcggtgga 1141 aatttgagct gtttaaactc tggatgcctt tttcagttct aatattccag atctccttgg 1201 tggataaaca cztcatttcc cttctcctga gcagagctcc tgagccctgg cccgctggaa 1261 cctgtcactt ctaaaaaagt tcgaggtccg gactgtctct cccggagcct tgaggctgat 1321 gagacggagc gagagagggg ccgggggcaa tggagtctac tcgcgggccc agggaggcgc 1381 cagagggccc cgggaccgac cgcaagaata acttccttcc tcttcccta acttcccggc 1441 agggctacgc ccagggtggg ggccccgagg gctggggcgt cggcttcccc ctggggatcc 1501 cccgcttcag agaagccaag cgttagcgca gccaaagccg gaggcacga agctccggcc 1561 cggggtggcg ctgggtcagg gtaccttctc ggcggtcccc tggccugccg aactcgcgcc WO 00/09525 PCTIUS99/17712 EPI-109 770 1621 tggtgtcctg tcaccccgct ccccgccctg agtgagcctg tcccctctca ggggcgcgcc 1681 cgagtcgctc cgggttggct gccaggtcca gagttaaact ttcagccaat gaaaaagggc 1741 gcgagggctg acgcacggaa acgtcatggg aattcccccc tccggggggc cgagaagggg 1801 ctttcccggc cctgagccct gctggcaggc gaggtgtcgc gaccggtccc aggtgggtcg 1861 ggcgcggaga gaagccgcaa ccagagccgc cgccacggtg agtggctgga ttcagacccc 1921 tgggtggccg ggacaagaga aaagagggag gagggccttt agcggacagc gcctggggct 1981 ggagagcagc agctgcacac agccggaaag ggcgcgcagg cgacgacact cggatccacg 2041 tcgacaccgt tgtacaaaga tacgcggacc cgtacgtaca cctgtacctg tgctggcgca 2101 cacacggcag cgtccgtgca gtcgcactcg cacacacatg cacacggaga cgtgcccacc 2161 ggtgcactgg tgcctgcacc cacacccttc acgcacaaac tcaagatacg ctcacccgtg 2221 tctgtacatc aagacaggcg ctgacacaca cccacactga gaagctcggg attcacctat 2281 ctacacacat gctcgcttgc acactcatgt tgacgccatg gacacacaac atgcaaccaa 2341 gcactacagc cgaaacacac ttgtggagct gtgatggaga cacactcttg tattaggtgg 2401 gggggggggg ggagcgtgca gagatctccc tgtcgcctgc gcgcccagaa ccggtgcggt 2461 gtgggaccag ctgctgttgt gaggtttggg agagagagaa aaagagccca ctccgaggag 2521 gagacacttt tcccgcagcc ccagaatcgc gttctcgggg cagaaccccg gggcctccca 2581 caggaaagag ccccgcctac aggctgttcg aaggggaggc cgtccgacag caggaatgtc 2641 cccccaaaag cccccggggt ttatcagccg tggcctccct cctggcagaa aatcccaagg 2701 ttgctccaga ccgggggagg ggagcgggag gcggacttgg ccccagactg ccagcctcct 2761 cccggccgtg aaagaccctc ctgttccctg ccctggaggg aggagggggc ttaacccacc 2821 ggggcttccc ggattctcct agacctctgc ccgctgaaaa gcagcgggac gccgtagact 2881 gtcgagggcc atcccgcccc tcccgtcgcg agggcggggc cagtggcgtc atttccaggc 2941 ccgccccctc cggccccgcc tccccttggt attttcggga ctttcctaag ctgctctaac 3001 tttcctgccc cttccccgcc aagcccaact ccggatctcg ctctccaccg gatctcaccc 3061 gccacacccg gacaggcggc tggaggaggt cggaccctcc cccaaatctg ggcccccatt 3121 ctcccgccca cccccattta gatctgaccc cctcccccac gccactcctc ccaactttag 3181 gcgggcgtct aaaattctgg gaagcagaac ctggccggag ccactagaca gagccgggcc 3241 taqcccagag acatggagag ttgctacaac ccagtgagtc atgccgcctg cccctgaccc 3301 ggccggctag cccctcgtgt ctgtccacct gtctgcccga gccccctact gctgccttac 3361 acctgtatgc ctcgcagatg ctctcagcct gccagtctgt ccatctgtct gcaactctgc 3421 ctccaaaagg agctttctct tgggtctgag gaggaggggg gagtgaccac tgaagacttg 3481 gaagatggga ggtggggcta gtgtgggggg tgctgagagt cggatgccac ccccagtctg 3541 tctccaaacc agggtctgga tggtattatt gaatatgatg atttcaaatt gaactcctcc 3601 attgtggaac ccaaggagcc agccccagaa acaggtcagc aagttcacta acctccccta 3661 gtctaaagcg ggggagggag agcatgtgcc ctctctctgg gggaggggtc tgggagatcg 3721 tgtgctcagc aaggtctctc tgtccccagc tgatggcccc tacctggtga tcgtggaaca 3781 gcctaagcag gttgagtgag caaaagggag ggatgtggaa tggcttcagc tttggggaca 3841 aatggggtag tgtagctggc tggcatggag gagcattgcc gaagaggccc acaggggatt 3901 ggatggtcac tgctgctgat cagagtgctg tagttttggt tcagggctac taccagcgac 3961 tcgggtcact gctggcctgg gtggtcttcc ctgatcacaa tgctactatg cccttgacct 4021 tcagagaggc ttccgatttc gatatggctg tgaaggcccc tcccatggag gactgcccgg 4081 tgcctccagt gagaagggcc gaaagaccta tcccactgtc aaggtgakcc aggatggtgc 4141 tggmgggtgg gctaagtgga cagcatgccc aaggccctga cgtgacagtc ccttgcctct 4201 cctagatctg taactacgag ggaccagcca agatcgaggt ggacctggta acacacagtg 4261 acccacctcg tgctcatgcc cacagtctgg tgggcaagca atgctcggag ctggggatct 4321 gcgccgtttc tgtggggccc aaggacatga ctgcccagta ggtgcccttc ttacgccttg 4381 gcccccactg gtatgccskt cwtgccagtc ccaggcccca gccacctcca tatgatgtta 4441 gcatctgacc aaggggaaan gatgtaggtt ggccccaaac ccaagggcct aagtagaaac 4501 tccaatggct tccttgagga agtaaggctg agctgagcct ggcaatggga aaggtgcctg 4561 gcaatgggaa aggtgcctca ggaagaaaga actgcatggc caaaggctcc cgattctctc 4621 ttctcagatt taacaacctg ggtgtcctgc atgtgactaa gaagaacatg atggggacta 4681 tgatacaaaa acttcagagg cagcggctcc gctctaggcc ccagggcctt acgggtatgg 4741 gtgcaggggg tgggtcgggt atgggtgcag ggggtgggtg ggtcatggga ggtgctcatg 4801 gaaggagcag ggagggagaa gccaggggtc acacatgtac ctactgccca gaggccgagc 4861 agcgggagct ggagcaagag gccaaagaac tgaagaaggt gatggatctg agtatagtgc 4921 ggctgcgctt ctctgccttc cttagagcca gtgatggctc cttctccctg cccctgaagc 4981 cagtcacctc ccagcccatc catgatagca gtgagtatcc tgattgcctg gggtgccagg 5041 cctggtsgsa gaggtggcat gaggggtgac ctcaagctgt gcagtcaaac aagacccagg 5101 tttcagaacc tgcsctgcca catatgagct gagtgatcct gagcaagtca tttccccccc (2) INFORMATION FOR SEQ ID NO:2601: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 3601 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2601 1 ggccaccgga gcggcccggc gacgatcgct gacagcttcc cctgcccttc ccgtcggtcg 61 ggccgccagc cgccgcagcc ctcggcctgc acgcagccac cggccccgct cccggagccc WO 00/09525 PCT/US99/17712 EPI-109 771 121 agcgccgccg aggccgcagc cgcccggcca gtaaggcggc gccgcccgcg gccaccgcgg 181 gccctgccgt tccctccgcc gcgctgcgcc atggcgcggc gctgactggc ctggcccggc 241 cccgccgcgc tcccgctcgc cccgacccgc actcgggccc gcccgggctc cggcctgccg 301 ccgcctcttc cttctccagc cggcaggccc cgccgcttag gagggagagc ccacccgcgc 361 caggaggccg aacgcggact cgccacccgg cttcagaatg gcagaagatg atccatattt 421 gggaaggcct gaacaaatgt ttcatttgga tccttctttg actcatacaa tatttaatcc 481 agaagtattt caaccacaga tggcactgcc aacagatggc ccataccttc aaatattaga 541 gcaacctaaa cagagaggat ttcgtttccg ttatgtatgt gaaggcccat cccatggtgg 601 actacctggt gcctctagtg aaaagaacaa gaagtcttac cctcaggtca aaatctgcaa 661 ctatgtggga ccaqcaaagg ttattgttca gttggtcaca aatggaaaaa atatccacct 721 gcatgcccac agcctggtgg gaaaacactg tgaggatggg atctgcactg taactgctgg 781 acccaaggac atggtggtcg gcttcgcaaa cctgggtata cttcatgtga caaagaaaaa 841 agtatttgaa acactggaag cacgaatgac agaggcgtgt ataaggggct ataatcctgg 901 actcttggtg caccctgacc ttgcctattt gcaagcagaa ggtggagggg accggcagct 961 gggagatcgg gaaaaagagc taatccgcca agcagctctg cagcagacca aggagatgga 1021 cctcagcgtg gtgcggctca tgtttacagc ttttcttccg gatagcactg gcagcttcac 1081 aaggcgcctg gaacccgtgg tatcagacgc catctatgac agtaaagccc ccaatgcatc 1141 caacttgaaa attgtaagaa tggacaggac agctggatgt gtgactggag gggaggaaat 1201 ttatcttctt tgtgacaaag ttcagaaaga tgacatccag attcgatttt atgaagagga 1261 agaaaatggt ggagtctggg aaggatttgg agatttttcc cccacagatg ttcatagaca 1321 atttgccatt gtcttcaaaa ctccaaagta taaagatatt aatattacaa aaccagcctc 1381 tgtgtttgtc cagcttcgga ggaaatctga cttggaaact agtgaaccaa aacctttcct 1441 ctactatcct gaaatcaaag ataaagaaga agtgcagagg aaacgtcaga agctcatgcc 1501 caatttttcg gatagtttcg gcggtggtag tggtgccgga gctggaggcg gaggcatgtt 1561 tggtagtggc ggtggaggag ggggcactgg aagtacaggt ccagggtata gcttcccaca 1621 ctatggattt cctacttatg gtgggattac tttccatcct ggaactacta aatctaatgc 1681 tgggatgaag catggaacca tggacactga atctaaaaag gaccctgaag gttgtgacaa 1741 aagtgatgac aaaaacactg taaacctctt tgggaaagtt attgaaacca cagagcaaga 1801 tcaggagccc agcgaggcca ccgttgggaa tggtgaggtc actctaacgt atgcaacagg 1861 aacaaaagaa gagagtgctg gagttcagga taacctcttt ctagagaagg ctatgcagct 1921 tgcaaagagg catgccaatg cccttttcga ctacgcggtg acaggagacg tgaagatgct 1981 gctggccgtc cagcgccatc tcactgctgt gcaggatgag aatggggaca gtgtcttaca 2041 cttagcaatc atccaccttc attctcaact tgtgagggat ctactagaag tcacatctgg 2101 tttgatttct gatgacatta tcaacatgag aaatgatctg taccagacgc ccttgcactt 2161 ggcagtgatc actaagcagg aagatgtggt ggaggatttg ctgagggctg gggccgacct 2221 gagccttctg gaccgcttgg gtaactctgt tttgcaccta gctgccaaag aaggacatga 2281 taaagttctc agtatcttac tcaagcacaa aaaggcagca ctacttcttg accaccccaa 2341 cggggacggt ctgaatgcca ttcatctagc catgatgagc aatagcctgc catgtttgct 2401 gctgctggtg gccgctgggg ctgacgtcaa tgctcaggag cagaagtccg ggcgcacagc 2461 actgcacctg gctgtggagc acgacaacat ctcattggca ggctgcctgc tcctggaggg 2521 tgatgcccat gtggacagta ctacctacga tggaaccaca cccctgcata tagcagctgg 2581 gagagggtcc accaggctgg cagctcttct caaagcagca ggagcagatc ccctggtgga 2641 gaactttgag cctctctatg acctggatga ctcttgggaa aatgcaggag aggatgaagg 2701 agttgtgcct ggaaccacgc ctctagatat ggccaccagc tggcaggtat ttgacatatt 2761 aaatgggaaa ccatatgagc cagagtttac atctgatgat ttactagcac aaggagacat 2821 gaaacagctg gctgaagatg tgaagctgca gctgtataag ttactagaaa ttcctgatcc 2881 agacaaaaac tgggctactc tggcgcagaa attaggtctg gggatactta ataatgcctt 2941 ccggctgagt cctgctcctt ccaaaacact tatggacaac tatgaggtct ctgggggtac 3001 agtcagagag ctggtggagg ccctgagaca aatgggctac accgaagcaa ttgaagtgat 3061 ccaggcagcc tccagcccag tgaagaccac ctctcaggcc cactcgctgc ctctctcgcc 3121 tgcctccaca aggcagcaaa tagacgagct ccgagacagt gacagtgtct gcgacacggg 3181 cgtggagaca tccttccgca aactcagctt taccgagtct ctgaccagtg gtgcctcact 3241 gctaactctc aacaaaatgc cccatgatta tgggcaggaa ggacctctag aaggcaaaat 3301 ttagcctgct gacaatttcc cacaccgtgt aaaccaaagc cctaaaattc cactgcgttg 3361 tccacaagac agaagctgaa gtgcatccaa aggtgctcag agagccggcc cgcctgaatc 3421 attctcgatt taactcgaga ccttttcaac ttggcttcct ttcttggttc ataaatgaat 3481 tttagtttgg ttcacttaca gatagtatct agcaatcaca acactggctg agcggatgca 3541 tctggggatg aggttgctta ctaagctttg ccagctgctg ctggatcaca gctgctttct 3601 gttgtcattg ctgttgtccc tctgc (2) INFORMATION FOR SEQ ID NO:2602: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1621 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (1D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO: 2602 1 actttcctgc cccttccccg gccaagccca actccggatc tcgctctcca ccggatcica 61 cccgccacac ccggacaggc ggctggagga ggcgggcgtc taaaattctg ggaagcagaa WO 00/09525 PCT/US99/17712 EPI-109 772 121 cctggccgga gccactagac agagccgggc ctagcccaga gacatagaga gttgctacaa 181 cccaggtctg gatggtatta ttgaatatga tgatttcaaa ttgaactcct ccattgtgga 241 acccaaggag ccagccccag aaacagctga tggcccctac ctggtgatcg tggaacagcc 301 taagcagaga ggcttccgat ttcgatatgg ctgtgaaggc ccctcccatg gaggactgcc 361 cggtgcctcc agtgagaagg gccgaaagac ctatcccact gtcaagatct gtaactacga 421 gggaccagcc aagatcgagg tggacctggt aacacacagt gacccacctc gtgctcatgc 481 ccacagtctg gtgggcaagc aatgctcgga gctggggatc tgcgccgttt ctgtggggcc 541 caaggacatg actgcccaat ttaacaacct gggtgtcctg catgtgacta agaagaacat 601 gatggggact atgatacaaa aacttcagag gcagcggctc cgctctaggc cccagggcct 661 tacggaggcc gagcagcggg agctggagca agaggccaaa gaactgaaga aggtgatgga 721 tctgagtata gtgcggctgc gcttctctgc cttccttaga gccagtgatg gctccttctc 781 cctgcccctg aagccagtca cctcccagcc catccatgat agcaaatctc cgggggcatc 841 aaacctgaag atttctcgaa tggacaagac agcaggctct gtgcggggtg gagatgaagt 901 ttatctgctt tgtgacaagg tgcagaaaga tgacattgag gttcggttct atgaggatga 961 tgagaatgga tggcaggcct ttggggactt ctctcccaca gatgtgcata aacagtatgc 1021 cattgtgttc cggacacccc cctatcacaa gatgaagatt gagcggcctg taacagtgtt 1081 tctgcaactg aaacgcaagc gaggagggga cgtgtctgat tccaaacagt tcacctatta 1141 ccctctggtg gaagacaagg aagaggtgca gcggaagcgg aggaaggcct tgcccacctt 1201 ctcccagccc ttcgggggtg gctcccacat gggtggaggc tctgggggtg cagccggggg 1261 ctacggagga gctggaggag gtgagggggt actgatggag ggaggggtaa aggtaagaga 1321 agctgtggag gaaaaaaatc tgggggaggc cgggcgtggc ttgcacgcct gtaatccagc 1381 ctttgggagg ccaaggcagg cagttacctg agatcaggag ttcaagacca gcttggccaa 1441 cagcgtgaaa cctcgtctct actaaaaata caaacattag ctgggcatgg tggcaggcgc 1501 ctgtaatccc agctactcgg gaggctgagg caggagaatc gcttgaaccc tgggagacaa 1561 gaggttgcag taagctgaga tcacaccact gcactccagg ctgggcaata agagcgaaac 1621 tccgtctcaa aaaaaaaaaa aaaaaaaaaa (2) INFORMATION FOR SEQ ID NO:2603: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 3061 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO: 2603 1 cacggtgagt ggctggattc agacccctgg gtggccggga caagagaaaa gagggaggag 61 ggcctttagc ggacagcgcc tggggctgga gagcagcagc tgcacacagc cggaaagggc 121 gcgcaggcga cgacactcgg atccacgtcg acaccgttgt acaaagatac gcggacccgc 181 gggcgtctaa aattctggga agcagaacct ggccggagcc actagacaga gccgggccta 241 gcccagagac atggagagtt gctacaaccc aggtctggat ggtattattg aatatgatga 301 tttcaaattg aactcctcca ttgtggaacc caaggagcca gccccagaaa cagctgatgg 361 cccctacctg gtgatcgtgg aacagcctaa gcagagaggc ttccgatttc gatatggctg 421 tgaaggcccc tcccatggag gactgcccgg tgcctccagt gagaagggcc gaaagaccta 481 tcccactgtc aagatctgta actacgaggg accagccaag atcgaggtgg acctggtaac 541 acacagtgac ccacctcgtg ctcatgccca cagtctggtg ggcaagcaat gctcggagct 601 ggggatctgc gccgtttctg tggggcccaa ggacatgact gcccaattta acaacctggg 661 tgtcctgcat gtgactaagg agaacatgat ggggactatg atacaaaaac ttcagaggca 721 gcggctccgc tctaggcccc agggccttac ggaggccgag cagcgggagc tggagcaaga 781 ggccaaagaa ctgaagaagg tgatggatct gagtatagtg cggctgcgct tctctgcctt 841 ccttagagcc agtgatggct ccttctccct gcccctgaag ccagtcatct cccagcccat 901 ccatgacagc aaatctccgg gggcatcaaa cctgaagatt tctcgaatgg acaagacagc 961 aggctctgtg cggggtggag atgaagttta tctgctttgt gacaaggtgc agaaagatga 1021 cattgaggtt cggttctatg aggatgatga gaatggatgg caggcctttg gggacttctc 1081 tcccacagat gtgcataaac agtatgccat tgtgttccgg acacccccct atcacaagat 1141 gaagattgag cggcctgtaa cagtgtttct gcaactgaaa cgcaagcgag gaggggacgt 1201 gtctqattcc aaacagttca cctattaccc tctggtggaa gacaaggaag aggtgcagcg 1261 gaagcggagg aaggccttgc ccaccttctc ccagcccttc gggggtggct cccacatggg 1321 tggaggctct gggggtgcag ccgggggcta cggaggagct ggaggaggtg gcagcctcgg 1381 tttcttcccc tcctccctqg cctacagccc ctaccagtcc ggcgcgggcc ccatgggctg 1441 ctacccggga ggcgggggcg gggcgcagat ggccgccacg gtgcccagca gggactccgg 1501 ggaggaagcc gcggagccga gcgccccctc caggaccccc cagtgcgacg cgcaggcccc 1561 ggagatgctg cagcgagctc gagagtacaa cgcgcgcctg ttcggcctgg cgcagcgcag 1621 cgcccgagcc ctactcgact acggcgtcac cgcggaccgg cgcgcgctgc tggcgggaca 1681 gcgccacctg ctgacggcgc aggacgagaa cggagacaca ccactgcacc tagccatcat 1741 ccacgggcag accagtgtca ttgagcagat agtctatgtc atccaccacg cccaggacct 1801 cggcgttgtc aacctcacca accacctgca ccagacgccc ctgcacctgg cggtgatcac 1861 ggggcagacg agtgtggtga gctttctgct gcgggtaggt gcagacccag ctctgctgga 1921 tcggcatgga gactcagcca tgcatctggc gctgcgggca ggcgctggtg ctcctgagct 1981 gctgcgtgca ctgcttcaga gtggagctcc tgctgtgccc cagctgttgc atatgcctga 2041 ctttgaggga ctgtatccag tacacctggc ggtccgagcc cgaagccctg agtgcctgga WO 00/09525 PCT/US99/17712 EPI-109 773 2101 tctgctggtg gacagtgggg ctgaagtgga ggccacagag cggcaggggg gacgaacagc 2161 cttgcatcta gccacaaaga tggaggagct ggggttggtc acccatctgg tcaccaagct 2221 ccgggccaac atgaacgctc gcacctttgc gggaaacaca cccctacacc tggcagctgg 2281 actggggtac ccgaccctca cccgcctcct tctgaaggct ggtgczgaca tccatgctga 2341 aaacgaggag cccctgtgcc cactgccttc accccctacc tctgatagcg actcggactc 2401 tgaagggcct gagaaggaca cccgaagcag cttccggggc cacacgcctc ttgacctcac 2461 ttgcagcacc aaggtgaaga ccttgctgct aaatgctgct cagaacacca tggagccacc 2521 cctgaccccg cccagcccag cagggccggg actgtcactt ggtgatacag ctctgcagaa 2581 cctggagcag ctgctagacg ggccagaagc ccagggcagc tgggcagagc tggcagagcg 2641 tctggggctg cacagcctgg tagacacgta ccgacagaca acctcaccca gtggcagcct 2701 cctgcgcagc tacgagctgg ctggcgggga cctggcaggt ctactggagg ccctgtctga 2761 catgggccta gaggagggag tgaggctgct gaggggtcca gaaacccgag acaagctgcc 2821 cagcacaaca gaggtgaagg aagacagtgc gtacgggagc cagtcagtgg agcagaaggc 2881 agagaagctg ggcccacccc ctgagccacc aggagggctc tgccacgggc acccccagcc 2941 tcaggtgcac tgacctgctg cctgccccca gcccccttcc cggaccccct gtacagcgtc 3001 cccacctatt tcaaatctta tttaacaccc cacacccacc cctcagttgg gacaaataaa 3061 ggattctcat gggaagggga ggacccctcc ttcccaactt aaaaaaaaaa aaa (2) INFORMATION FOR SEQ ID NO:2604: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 13384 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2604 1 agcttcatcc tggagtcaac agattgggtt tgaatcctgg ctctgtccct ttctagctgt 61 gtgtttggtt gttactccac ctctctgagc cttaatttct tcatcagtaa aagtaatatt 121 cacctcctag ggttgttggg agggagaata agaacttcta aagtacccga acctagcaac 181 taggacacta tatttgcagg caagatgaag aggggtgggg aagtaatagg aaacagccca 241 aatcgagagc cataatagtc tctctttact tagtgccagt gcaggcctgt gattctgttc 301 ttaaaaacgt ccggggcaag ctgcaggaaa gacccgagat agcttatgtt ctaccataag 361 ccttaaggga ggaggactcc aggcagggag acttaccatg gcacctctaa gagaaagcct 421 actgaccaga gagaggtcag tcatgtactc ccgtagcttc ttagaatttc tgatctgact 481 cgctgcctct agagttgttc aggtggaaat tggaaggcta tagaggaatt cggcagcata 541 cagtggctca cgtctgtaat ccaaaatcca agcattttgg aaggccaaag taggaggatc 601 acttaagccc aggagtttaa gaccagccta ggcaaccgag tgagatccat ctccactaaa 661 aaattttaaa atttgccagg tatggtggtg tgcacctgta gccccagcta ctcaggagag 721 tcagagaatc ggcgcacccc ggagttcgag gttgcagtga gccatgatca cgccactgta 781 ctccagcctg ggtgacagag aagaccacct gtctcaaaaa acataaataa ataaataaat 841 aaataggccg tgcgcagcgg ctcacgactg taattccaac attttagaag gcggaggcag 901 cggatcacct gaggtcagga gttcgggacc agcctgacca acgtggtgaa accccaactc 961 tactaaaaat acataaatta ggcggggcgt ggtggtggcc gcctgtaatc ccagctactc 1021 ggtaggctgc agcaggagaa tggtttgaac ccgggaggca gaggttgcag tgagccaaaa 1081 tcccctcact gcattccagc ctgagactaa aaaaaagagg cgattccca catcggtgga 1141 aatttgagct gtttaaactc tggatgcctt tttcagttct aatattccag atctccttgg 1201 tggataaaca cttcatttcc cttctcctga gcagagctcc tgagccctgg cccgctggaa 1261 cctgtcactt ccaaaaaagt tcgaggtccg gactgtctct cccggagcct tgaggctgat 1321 gagacggagc gagagagggg ccgggggcaa tggagtctac tcgcgggccc agggaggcgc 1381 cagagggccc cgggaccgac cgcaagaata acttccttcc tcttccgcta acttcccggc 1441 agggctacgc tcagggtggg ggccccgagg gctggggcgt cggcttcccc ctggggatcc 1501 cccgcttcag agaagccaag cgttagcgca gccaaagccg gaggcagcga agctccggcc 1561 cggggtggcg ctgggtcagg gtaccttctc ggcggtcccc tggccggccg aactcgcgcc 1621 tggtgtcctg tcaccccgct ccccgccctg agtgagcctg tcccctctca ggggcgcgcc 1681 cgagtcgctc cgggttggct gccaggtcca gagttaaact ttcagccaat gaaaaagggc 1741 gcgagggctg acgcacggaa acgtcatggg aattcccccc tccggggggc cgagaagggg 1801 ctttcccggc cctgagccct gctggcaggc gaggtgtcgc gaccggtccc aggtgggtcg 1861 ggcgcggaga gaagccgcaa ccagagccgc cgccacggtg agtggctgga ttcagacccc 1921 tgggtggccg ggacaagaga aaagagggag gagggccttt agcggacagc gcctggggct 1981 ggagagcagc agcgcacac agccggaaag ggcgcgcagg cgacgacact cggatccacg 2041 tcgacaccgt tgzacaaaga tacgcggacc cgtacgtaca cctgtacctg tgctggcgca 2101 cacacggcag cctccgtgca gtcgcactcg cacacacatg cacacggaga cgtgcccacc 2161 ggtgcactgg tgcctgcacc cacacccttc acgcacaaac tcaagatacg ctcacccgtg 2221 tctgtacatc aaaacaggcg ctgacacaca cccacactga gaagctcggg attcacctat 2281 ctacacacat gczcgcttgc acactcatgt tgacgccatg gacacacaac atgcaaccaa 2341 gcactacagc cgaaacacac ttgtggagct gtgatggaga cacactcttg tattaggtgg 2401 gggggggggg ggagcgtgca gagatctccc tgtcgcctgc gcgcccagaa ccggtgcggt 2461 gtgggaccag ctgctgttgt gaggtttggg agagagagaa aaagagccca ctccgaggag 2521 gagacacttt tcccgcagcc ccagaatcgc gttctcgggg cagaaccccg gggcctccca 2581 caggaaagag ccccgcctac aggctgttcg aaggggaggc cgtccgacag caggaatgtc WO 00/09525 PCT/US99/17712 EPI-109 774 2641 cccccaaaag cccccggggt ttatcagccg tggcctccct cctggcagaa aatcccaagg 2701 ttgctccaga ccgggggagg ggagcgggag gcggacttgg ccccagactg ccaqcctcct 2761 cccggccgtg aaagaccctc ctgttccctg ccctggaggg aggagggggc ttaacccacc 2821 ggggcttccc ggattctcct agacctctgc ccgctgaaaa gcagcgggac gccgtagact 2881 gtcgagggcc atcccgcccc tcccgtcgcg agggcggggc cagtggcgtc atttccaggc 2941 ccgccccctc cggccccgcc tccccttggt attttcggga ctttcctaag ctgctctaac 3001 tttcctgccc cttccccgcc aagcccaact ccggatctcg ctctccaccg gatctcaccc 3061 gccacacccg gacaggcggc tggaggaggt cggaccctcc cccaaatctg ggcccccatt 3121 ctcccgccca cccccattta gatctgaccc cctcccccac gccactcctc ccaactttag 3181 gcgggcgtct aaaattctgg gaagcagaac ctggccggag ccactagaca gagccgggcc 3241 tagcccagag acatggagag ttgctacaac ccagtgagtc atgccgcctg cccctgaccc 3301 ggccggctag cccctcgtgt ctgtccacct gtctgcccga gccccctact gctgccttac 3361 acctgtatgc ctcgcagatg ctctcagcct gccagtctgt ccatctgtct gcaactctgc 3421 ctccaaaagg agctttctct tgggtctgag gaggaggggg gagtgaccac tgaagacttg 3481 gaagatggga ggtggggcta gtgtgggggg tgctgagagt cggatgccac ccccagtctg 3541 tctccaaacc agggtctgga tggtattatt gaatatgatg atttcaaatt gaactcctcc 3601 attgtggaac ccaaggagcc agccccagaa acaggtcagc aagttcacta acctccccta 3661 gtctaaagcg ggggagggag agcatgtgcc ctctctctgg gggaggggtc tgggagatcg 3721 tgtgctcagc aaggtctctc tgtccccagc tgatggcccc tacctggtga tcgtggaaca 3781 gcctaagcag gttgagtgag caaaagggag ggatgtggaa tggcttcagc tttggggaca 3841 aatggggtag tgtagctggc tggcatggag gagcattgcc gaagaggccc acaggggatt 3901 ggatggtcac tgctgctgat cagagtgccg taqttttggt tcagggctac taccagogac 3961 tcgggtcact gctggcctgg gtggtcttcc ctgatcacaa tgctactatg cccttgacct 4021 tcagagaggc ttccgatttc gatatggctg tgaaggcccc tcccatggag gactgcccgg 4081 tgcctccagt gagaagggcc gaaagaccta tcccactgtc aaggtgakcc aggatggtgc 4141 tggmgggtgg gctaagtgga cagcatgccc aaggccctga cgtgacagtc ccttgcctct 4201 cctagatctg taactacgag ggaccagcca agatcgaggt ggacctggta acacacagtg 4261 acccacctcg tgctcatgcc cacagtctgg tgggcaagca atgctcggag ctggggatct 4321 gcgccgtttc tgtggggccc aaggacatga ctgcccagta ggtgcccttc ttacgccttg 4381 gcccccactg gtatgccskt cwtgccagtc ccaggcccca gccacctcca tatgatgtta 4441 gcatctgacc aaggggaaan gatgtaggtt ggccccaaac ccaagggcct aagtagaaac 4501 tccaatggct tccttgagga agtaaggctg agctgagcct ggcaatggga aaggtgcctg 4561 gcaatgggaa aggtgcctca ggaagaaaga actgcatggc caaaggctcc cgattctctc 4621 ttctcagatt taacaacctg ggtgtcctgc atgtgactaa gaagaacatg atggggacta 4681 tgatacaaaa acttcagagg cagcggctcc gctctaggcc ccagggcctt acgggtatgg 4741 gtgcaggggg tgggtcgggt atgggtgcag ggggtgggtg ggtcatggga ggtgctcatg 4801 gaaggagcag ggagggagaa gccaggggtc acacatgtac ctactgccca gaggccgagc 4861 agcgggagct ggagcaagag gccaaagaac tgaagaaggt gatggatctg agtatagtgc 4921 ggctgcgctt ctctgccttc cttagagcca gtgatggctc cttctccctg cccctgaagc 4981 cagtcacctc ccagcccatc catgatagca gtgagtatcc tgattgcctg gggtgccagg 5041 cctggtsgsa gaggtggcat gaggggtgac ctcaagctgt gcagtcaaac aagacccagg 5101 tttcagaacc tgcsctgcca catatgagct gagtgatcct gagcaagtca tttccccccc 1 ggccaccgga gcggcccggc gacgatcgct gacagcttcc cctgcccttc ccgtcggtcg 61 ggccgccagc cgccgcagcc ctcggcctgc acgcagccac cggccccgct cccggagccc 121 agcgccgccg aggccgcagc cgcccggcca gtaaggcggc gccgcccgcg gccaccgcgg 181 gccctgccgt tccctccgcc gcgctgcgcc atggcgcggc gctgactggc ctggcccggc 241 cccgccgcgc tcccgctcgc cccgacccgc actcgggccc gcccgggctc cggcctgccg 301 ccgcctcttc cttctccagc cggcaggccc cgccgcttag gagggagagc ccacccgcgc 361 caggaggccg aacgcggact cgccacccgg cttcagaatg gcagaagatg atccatattt 421 gggaaggcct gaacaaatgt ttcatttgga tccttctttg actcatacaa tatttaatcc 481 agaagtattt caaccacaga tggcactgcc aacagatggc ccataccttc aaatattaga 541 gcaacctaaa cagagaggat ttcgtttccg ttatgtatgt gaaggcccat cccatggtgg 601 actacctggt gcctctagtg aaaagaacaa gaagtcttac cctcaggtca aaatctgcaa 661 ctatgtggga ccagcaaagg ttattgttca gttggtcaca aatggaaaaa atatccacct 721 gcatgcccac agcctggtgg gaaaacactg tgaggatggg atctgcactg taactgctgg 781 acccaaggac atggtggtcg gcttcgcaaa cctgggtata cttcatgtga caaagaaaaa 841 agtatttgaa acactggaag cacgaatgac agaggcgtgt ataaggggct ataatcctgg 901 actcttggtg caccctgacc ttgcctattt gcaagcagaa ggtggagggg accggcagct 961 gggagatcgg gaaaaagagc taatccgcca agcagctctg cagcagacca aggagatgga 1021 cctcagcgtg gtgcggctca tgtttacagc ttttcttccg gatagcactg gcagcttcac 1081 aaggcgcctg gaacccgtgg tatcagacgc catctatgac agtaaagccc ccaatgcatc 1141 caacttgaaa attgtaagaa tggacaggac agctggatgt gtgactggag gggaggaaat 1201 ttatcttctt tgtgacaaag ttcagaaaga tgacatccag attcgatttt atgaagagga 1261 agaaaatggt ggagtctggg aaggatttgg agatttttcc cccacagatg ttcatagaca 1321 atttgccatt gtcttcaaaa ctccaaagta taaagatatt aatattacaa aaccagcctc 1381 tgtgtttgtc cagcttcgga ggaaatctga cttggaaact agtgaaccaa aacctttcct 1441 ctactatcct gaaatcaaag ataaagaaga agtgcagagg aaacgtcaga agctcatgcc 1501 caatttttcg gatagtttcg gcggtggtag tggtgccgga gctggaggcg gaggcatgtt WO 00/09525 PCT/US99/17712 EPI-109 775 1561 tggtagtggc ggtggaggag ggggcactgg aagtacaggt ccagggtata gcttcccaca 1621 ctatggattt cctacttatg gtgggattac tttccatcct ggaactacta aatctaatgc 1681 tgggatgaag catggaacca tggacactga atctaaaaag gaccctgaag gttgtgacaa 1741 aagtgatgac aaaaacactg taaacctctt tgggaaagtt attgaaacca cagagcaaga 1801 tcaggagccc agcgaggcca ccgttgggaa tggtgaggtc actctaacgt atgcaacagg 1861 aacaaaagaa gagagtgctg gagttcagga taacctcttt ctagagaagg ctatgcagct 1921 tgcaaagagg catgccaatg cccttttcga ctacgcggtg acaggagacg tgaagatgct 1981 gctggccgtc cagcgccatc tcactgctgt gcaggatgag aatggggaca gtgtcttaca 2041 cttagcaatc atccaccttc attctcaact tgtgagggat ctactagaag tcacatctgg 2101 tttgatttct gatgacatta tcaacatgag aaatgatctg taccagacgc ccttgcactt 2161 ggcagtgatc actaagcagg aagatgtggt ggaggatttg ctgagggctg gggccgacct 2221 gagccttctg gaccgcttgg gtaactctgt tttgcaccta gctgccaaag aaggacatga 2281 taaagttctc agtatcttac tcaagcacaa aaaggcagca ctacttcttg accaccccaa 2341 cggggacggt ctgaatgcca ttcatctagc catgatgagc aatagcctgc catgtttgct 2401 gctgctggtg gccgctgggg ctgacgtcaa tgctcaggag cagaagtccg ggcgcacagc 2461 actgcacctg gctgtggagc acgacaacat ctcattggca ggctgcctgc tcctggaggg 2521 tgatgcccat gtggacagta ctacctacga tggaaccaca cccctgcata tagcagctgg 2581 gagagggtcc accaggctgg cagctcttct caaagcagca ggagcagatc ccctggtgga 2641 gaactttgag cctctctatg acctggatga ctcttgggaa aatgcaggag aggatgaagg 2701 agttgtgcct ggaaccacgc ctctagatat ggccaccagc tggcaggtat ttgacatatt 2761 aaatgggaaa ccatatgagc cagagtttac atctgatgat ttactagcac aaggagacat 2821 gaaacagctg gctgaagatg tgaagctgca gctgtataag ttactagaaa ttcctgatcc 2881 agacaaaaac tgggctactc tggcgcagaa attaggtctg gggatactta ataatgcctt 2941 ccggctgagt cctgctcctt ccaaaacact tatggacaac tatgaggtct ctgggggtac 3001 agtcagagag ctggtggagg ccctgagaca aatgggctac accgaagcaa ttgaagtgat 3061 ccaggcagcc tccagcccag tgaagaccac ctctcaggcc cactcgctgc ctctctcgcc 3121 tgcctccaca aggcagcaaa tagacgagct ccgagacagt gacagtgtct gcgacacggg 3181 cgtggagaca tccttccgca aactcagctt taccgagtct ctgaccagtg gtgcctcact 3241 gctaactctc aacaaaatgc cccatgatta tgggcaggaa ggacctctag aaggcaaaat 3301 ttagcctgct gacaatttcc cacaccgtgt aaaccaaagc cctaaaattc cactgcgttg 3361 tccacaagac agaagctgaa gtgcatccaa aggtgctcag agagccggcc cgcctgaatc 3421 attctcgatt taactcgaga ccttttcaac ttggcttcct ttcttggttc ataaatgaat 3481 tttagtttgg ttcacttaca gatagtatct agcaatcaca acactggctg agcggatgca 3541 tctggggatg aggttgctta ctaagctttg ccagctgctg ctggatcaca gctgctttct 3601 gttgtcattg ctgttgtccc tctgc 1 actttcctgc cccttccccg gccaagccca actccggatc tcgctctcca ccggatctca 61 cccgccacac ccggacaggc ggctggagga ggcgggcgtc taaaattctg ggaagcagaa 121 cctggccgga gccactagac agagccgggc ctagcccaga gacatggaga gttgctacaa 181 cccaggtctg gatggtatta ttgaatatga tgatttcaaa ttgaactcct ccattgtgga 241 acccaaggag ccagccccag aaacagctga tggcccctac ctggtgatcg tggaacagcc 301 taagcagaga ggcttccgat ttcgatatgg ctgtgaaggc ccctcccatg gaggactgcc 361 cggtgcctcc agtgagaagg gccgaaagac ctatcccact gtcaagatct gtaactacga 421 gggaccagcc aagatcgagg tggacctggt aacacacagt gacccacctc gtgctcatgc 481 ccacagtctg gtgggcaagc aatgctcgga gctggggatc tgcgccgttt ctgtggggcc 541 caaggacatg actgcccaat ttaacaacct gggtgtcctg catgtgacta agaagaacat 601 gatggggact atgatacaaa aacttcagag gcagcggctc cgctctaggc cccagggcct 661 tacggaggcc gagcagcggg agctggagca agaggccaaa gaactgaaga aggtgatgga 721 tctgagtata gtgcggctgc gcttctctgc cttccttaga gccagtgatg gctccttctc 781 cctgcccctg aagccagtca cctcccagcc catccatgat agcaaatctc cgggggcatc 841 aaacctgaag atttctcgaa tggacaagac agcaggctct gtgcggggtg gagatgaagt 901 ttatctgctt tgtgacaagg tgcagaaaga tgacattgag gttcggttct atgaggatga 961 tgagaatgga tggcaggcct ttggggactt ctctcccaca gatgtgcata aacagtatgc 1021 cattgtgttc cggacacccc cctatcacaa gatgaagatt gagcggcctg taacagtgtt 1081 tctgcaactg aaacgcaagc gaggagggga cgtgtctgat tccaaacagt tcacctatta 1141 ccctctggtg gaagacaagg aagaggtgca gcggaagcgg aggaaggcct tgcccacctt 1201 ctcccagccc ttcgggggtg gctcccacat gggtggaggc tctgggggtg cagccggggg 1261 ctacggagga gctggaggag gtgagggggt actgatggag ggaggggtaa aggtaagaga 1321 agctgtggag gaaaaaaatc tgggggaggc cgggcgtggc ttgcacgcct gtaatccagc 1381 ctttgggagg ccaaggcagg cagttacctg agatcaggag ttcaagacca gcttggccaa 1441 cagcgtgaaa cctcgtctct actaaaaata caaacattag ctgggcatgg tggcaggcgc 1501 ctgtaatccc agctactcgg gaggctgagg caggagaatc gcttgaaccc tgggagacaa 1561 gaggttgcag taagctgaga tcacaccact gcactccagg ctgggcaata agagcgaaac 1621 tccgtctcaa aaaaaaaaaa aaaaaaaaaa 1 cacggtgagt ggctggattc agacccctgg gtggccggga caagagaaaa gagggaggag 61 ggcctttagc ggacagcgcc tggggctgga gagcagcagc tgcacacagc cggaaagggc 121 gcgcaggcga cgacactcgg atccacgtcg acaccgttgt acaaagatac gcggacccgc 181 gggcgtctaa aattctggga agcagaacct ggccggagcc actagacaga gccgggccta 241 gcccagagac atggagagtt gctacaaccc aggtctggat ggtattattg aatatgatga WO 00/09525 PCT/US99/17712 EPI-109 776 301 tttcaaattg aactcctcca ttgtggaacc caaggagcca gccccagaaa cagctgatgg 361 cccctacctg gtgatcgtgg aacagcctaa gcagagaggc ttccgatttc gatatggctg 421 tgaaggcccc tcccatggag gactgcccgg tgcctccagt gagaagggcc gaaagaccta 481 tcccactgtc aagatctgta actacgaggg accagccaag atcgaggtgg acctggtaac 541 acacagtgac ccacctcgtg ctcatgccca cagtctggtg ggcaagcaat gctcggagct 601 ggggatctgc gccgtttctg tggggcccaa ggacatgact gcccaattta acaacctggg 661 tgtcctgcat gtgactaagg agaacatgat ggggactatg atacaaaaac ttcagaggca 721 gcggctccgc tctaggcccc agggccttac ggaggccgag cagcgggagc tggagcaaga 781 ggccaaagaa ctgaagaagg tgatggatct gagtatagtg cggctgcgct tctctgcctt 841 ccttagagcc agtgatggct ccttctccct gcccctgaag ccagtcatct cccagcccat 901 ccatgacagc aaatctccgg gggcatcaaa cctgaagatt tctcgaatgg acaagacagc 961 aggctctgtg cggggtggag atgaagttta tctgctttgt gacaaggtgc agaaagatga 1021 cattgaggtt cggttctatg aggatgatga gaatggatgg caggccrttg gggacttctc 1081 tcccacagat gtgcataaac agtatgccat tgtgttccgg acacccccct atcacaagat 1141 gaagattgag cggcctgtaa cagtgtttct gcaactgaaa cgcaagcgag gaggggacgt 1201 gtctgattcc aaacagttca cctattaccc tctggtggaa gacaaggaag aggtgcagcg 1261 gaagcggagg aaggccttgc ccaccttctc ccagcccttc gggggtggct cccacatggg 1321 tggaggctct gggggtgcag ccgggggcta cggaggagct ggaggaggtg gcagcctcgg 1381 tttcttcccc tcctccctgg cctacagccc ctaccagtcc ggcgcgggcc ccatgggctg 1441 ctacccggga ggcgggggcg gggcgcagat ggccgccacg gtgcccagca gggactccgg 1501 ggaggaagcc gcggagccga gcgccccctc caggaccccc cagtgcgacg cgcaggcccc 1561 ggagatgctg cagcgagctc gagagtacaa cgcgcgcctg ttcggcctgg cgcagcgcag 1621 cgcccgagcc ctactcgact acggcgtcac cgcggaccgg cgcgcgctgc tggcgggaca 1681 gcgccacctg ctgacggcgc aggacgagaa cggagacaca ccactgcacc tagccatcat 1741 ccacgggcag accagtgtca ttgagcagat agtctatgtc atccaccacg cccaggacct 1801 cggcgttgtc aacctcacca accacctgca ccagacgccc ctgcacctgg cggtgatcac 1861 ggggcagacg agtgtggtga gctttctgct gcgggtaggt gcagacccag ctctgctgga 1921 tcggcatgga gactcagcca tgcatctggc gctgcgggca ggcgctggtg ctcctgagct 1981 gctgcgtgca ctgcttcaga gtggagctcc tgctgtgccc cagctgttgc atatgcctga 2041 ctttgaggga ctgtatccag tacacctggc ggtccgagcc cgaagccctg agtgcctgga 2101 tctgctggtg gacagtgggg ctgaagtgga ggccacagag cggcaggggg gacgaacagc 2161 cttgcatcta gccacagaga tggaggagct ggggttggtc acccatctgg tcaccaagct 2221 ccgggccaac gtgaacgctc gcacctttgc gggaaacaca cccctgcacc tggcagctgg 2281 actggggtac ccgaccctca cccgcctcct tctgaaggct ggtgctgaca tccatgctga 2341 aaacgaggag cccctgtgcc cactgccttc accccctacc tctgatagcg actcggactc 2401 tgaagggcct gagaaggaca cccgaagcag cttccggggc cacacgcctc ttgacctcac 2461 ttgcagcacc aaggtgaaga ccttgctgct aaatgctgct cagaacacca tggagccacc 2521 cctgaccccg cccagcccag cagggccggg actgtcactt ggtgatacag ctctgcagaa 2581 cctggagcag ctgctagacg ggccagaagc ccagggcagc tgggcagagc tggcagagcg 2641 tctggggctg cgcagcctgg tagacacgta ccgacagaca acctcaccca gtggcagcct 2701 cctgcgcagc tacgagctgg ctggcgggga cctggcaggt ctactggagg ccctgtctga 2761 catgggccta gaggagggag tgaggctgct gaggggtcca gaaacccgag acaagctgcc 2821 cagcacaaca gaggtgaagg aagacagtgc gtacgggagc cagtcagtgg agcagaaggc 2881 agagaagctg ggcccacccc ctgagccacc aggagggctc tgccacgggc acccccagcc 2941 tcaggtgcac tgacctgctg cctgccccca gcccccttcc cggaccccct gtacagcgtc 3001 cccacctatt tcaaatctta tttaacaccc cacacccacc cctcagttgg gacaaataaa 3061 ggattctcat gggaagggga ggacccctcc ttcccaactt aaaaaaaaaa aaa (2) INFORMATION FOR SEQ ID NO:2605: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 2161 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO: 2605 1 atgacagcaa aagattcttc aaaggaactt actgcttctg aacctgaggt ttgcataaag 61 actttcaagg agcaaatgca tttagaactt gagcttccga gattaccagg aaacagacct 121 acatctccta aaatttctcc acgcagttca ccaaggaact caccatgctt tttcagaaag 181 ttactggtga ataaaagcat tcggcagcgt cgtcgcttca ctgtggctca tacatgcttt 241 gatgtggaaa atggcccttc cccaggtcgg agtccactgg atccccaggc cagctcttcc 301 gctgggctgg tacttcacgc cacctttcct gggcacagcc agcgcagaga gtcatttctc 361 tacagatcag acagcgacta tgacttgtca ccaaaggcga tgtcgagaaa ctcttctctt 421 ccaagcgagc aacacggcga tgacttgatt gtaactcctt ttgcccaggt ccttgccagc 481 ttgcgaagtg tgagaaacaa cttcactata ctgacaaacc ttcatggtac atctaacaag 541 aggtccccag ctgctagtca gcctcctgtc tccagagtca acccacaaga agaatcttat 601 caaaaattag caatggaaac gctggaggaa ttagactggt gtttagacca gctagagacc 661 atacagacct accggtctgt cagtgagatg gcttctaaca agttcaaaag aatgctgaac 721 cgggagctga cacacctctc agagatgagc cgatcaggga accaggtgtc tgaatacatt WO 00/09525 PCT/US99/17712 EPI-109 777 781 tcaaatactt tcttagacaa gcagaatgat gtggagatcc catctcctac ccagaaagac 841 agggagaaaa agaaaaagca gcagctcatg acccagataa gtggagtgaa gaaattaatg 901 catagttcaa gcctaaacaa tacaagcatc tcacgctttg gagtcaacac tgaaaatgaa 961 gatcacctgg ccaaggagct ggaagacctg aacaaatggg gtcttaacat ctttaatgtg 1021 gctggatatt ctcacaatag acccctaaca tgcatcatgt atgctatatt ccaggaaaga 1081 gacctcctaa agacattcag aatctcatct gacacattta taacctacat gatgacttta 1141 gaagaccatt accattctga cgtggcatat cacaacagcc tgcacgctgc tgatgtagcc 1201 cagtcgaccc atgttctcct ttctacacca gcattagacg ctgtcttcac agatttggag 1261 atcctggctg ccatttttgc agctgccatc catgacgttg atcaccctgg agtctccaat 1321 cagtttctca tcaacacaaa ttcagaactt gctttgatgt ataatgatga atctgtgttg 1381 gaaaatcatc accttgctgt gggtttcaaa ctgctgcaag aagaacactg tgacatcttc 1441 atgaatctca ccaagaagca gcgtcagaca ctcaggaaga tggttattga catggtgtta 1501 gcaactgata tgtctaaaca tatgagcctg ctggcagacc tgaagacaat ggtagaaacg 1561 aagaaagtta caagttcagg cgttcttctc ctagacaact ataccgatcg cattcaggtc 1621 cttcgcaaca tggtacactg tgcagacctg agcaacccca ccaagtcctt ggaattgtat 1681 cggcaatgga cagaccgcat catggaggaa tttttccagc agggagacaa agagcgggag 1741 aggggaatgg aaattagccc aatgtgtgat aaacacacag cttctgtgga aaaatcccag 1801 gttggtttca tcgactacat tgtccatcca ttgtgggaga catgggcaga tttggtacag 1861 cctgatgctc aggacattct cgatacctta gaagataaca ggaactggta tcagagcatg 1921 atacctcaaa gtccctcacc accactggac gagcagaaca gggactgcca gggtctgatg 1981 gagaagtttc agtttgaact gactctcgat gaggaagatt ctgaaggacc tgagaaggag 2041 ggagagggac acagctattt cagcagcaca aagacgcttt gtgtgattga tccagaaaac 2101 agagattccc tgggagagac tgacatagac attgcaacag aagacaagtc ccccgtggat 2161 aca (2) INFORMATION FOR SEQ ID NO:2606: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 301 base pairs (B) TYPE: nucleic acid (C) STRAI4DEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO: 2606 1 tatcacaaca gcatgcacgc agccgatgtt acccagacag tccattgctt cttgctccgc 61 acagggatgg tgcactgcct gtcggagatt gagctcctgg ccatcatctt tgctgcagct 121 atccatgatt atgagcacac gggcactacc aacagcttcc acatccagac caagtcagaa 181 tgtgccatcg tgtacaatga tcgttcagtg ctggagaatc accacatcag ctctgttttc 241 cgattgatgc aggatgatga gatgaacatt ttcatcaacc tcaccaagga tgagtttgta 301 gaactccgag ccctggtcat tgagatggtg ttggctacag atatggca (2) INFORMATION FOR SEQ ID NO:2607: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 2462 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi(SEQUENCE DESCRIPTION: SEQ ID NO: 2607 1 atgacagcaa aagattcttc aaaggaactt actgcttctg aacctgaggt ttgcataaag 61 actttcaagg agcaaatgca tttagaactt gagcttccga gattaccagg aaacagacct 121 acatctccta aaatttctcc acgcagttca ccaaggaact caccatgctt tttcagaaag 181 ttactggtga ataaaagcat tcggcagcgt cgtcgcttca ctgtggctca tacatgcttt 241 gatgtggaaa atggcccttc cccaggtcgg agtccactgg atccccaggc cagctcttcc 301 gctgggctgg tacttcacgc cacctttcct gggcacagcc agcgcagaga gtcatttctc 361 tacagatcag acagcgacta tgacttgtca ccaaaggcga tgtcgagaaa ctcttctctt 421 ccaagcgagc aacacggcga tgacttgatt gtaactcctt ttgcccaggt ccttgccagc 481 ttgcgaagtg tgagaaacaa cttcactata ctgacaaacc ttcatggtac atctaacaag 541 aggtccccag ctgctagtca gcctcctgtc tccagagtca acccacaaga agaatcttat 601 caaaaattag caatggaaac gctggaggaa ttagactggt gtttagacca gctagagacc 661 atacagacct accggtctgt cagtgagatg gcttctaaca agttcaaaag aatgctgaac 721 cgggagctga cacacctctc agagatgagc cgatcaggga accaggtgtc tgaatacatt 781 tcaaatactt tcttagacaa gcagaatgat gtggagatcc catctcctac ccagaaagac 841 agggagaaaa agaaaaagca gcagctcatg acccagataa gtggagtgaa gaaattaatg 901 catagttcaa gcctaaacaa tacaagcatc tcacgctttg gagtcaacac tgaaaatgaa 961 gatcacctgg ccaaggagct ggaagacctg aacaaatggg gtcttaacat ctttaatgtg 1021 gctggatatt ctcacaatag acccctaaca tgcatcatgt atgctatatt ccaggaaaga 1081 gacctcctaa agacattcag aatctcatct gacacattta taacctacat gatgacttta 1141 gaagaccatt accattctga cgtggcatat cacaacagcc tgcacgctgc tgatgtagcc 1201 cagtcgaccc atgttctcct ttctacacca gcattagacg ctgtcttcac agatttggag 1261 atcctggctg ccatttttgc agctgccatc catgacgttg atcatcctgg agtctccaat 1321 cagtttctca tcaacacaaa ttcagaactt gctttgatgt ataatgatga atctgtgttg WO 00/09525 PCT/US99/17712 EPI-109 778 1381 gaaaatcatc accttgctgt gggtttcaaa ctgctgcaag aagaacactg tgacatctc 1441 atgaatctca ccaagaagca gcgtcagaca ctcaggaaga tggttattga catggtgtta 1501 gcaactgata tgtctaaaca tatgagcctg ctggcagacc tgaagacaat ggtagaaacg 1561 aagaaagtta caagttcagg cgttcttctc ctagacaact ataccgatcg cattcaggtc 1621 cttcgcaaca tggtacactg tgcagacctg agcaacccca ccaagtcctt ggaattgtat 1681 cggcaatgga cagaccgcat catggaggaa tttttccagc agggagacaa agagcgggag 1741 aggggaatgg aaattagccc aatgtgtgat aaacacacag cttctgtgga aaaatcccag 1801 gttggtttca togactacat tgtccatcca ttgtgggaga catgggcaga tttggtacag 1861 cctgatgctc aggacattct cgatacctta gaagataaca ggaactggta tcagagcatg 1921 atacctcaaa gtccctcacc accactggac gagcagaaca gggactgcca gggtctgatg 1981 gagaagtttc agtttgaact gactctcgat gaggaagatt ctgaaggacc tgagaaggag 2041 ggagagggac acagctattt cagcagcaca aagacgcttt gtgtgattga tccagaaaac 2101 agagattccc tgggagagac tgacatagac attgcaacag aagacaagtc ccccgtggat 2161 aca 1 tatcacaaca gcatgcacgc agccgatgtt acccagacag tccattgctt cttgctccgc 61 acagggatgg tgcactgcct gtcggagatt gagctcctgg ccatcatctt tgctgcagct 121 atccatgatt atgagcacac gggcactacc aacagcttcc acatccagac caagtcagaa 181 tgtgccatcg tgtacaactga tcgttcagtg ctggagaatc accacatcag ctctgttttc 241 cgattgatgc aggatgatga gatgaacatt ttcatcaacc tcaccaagga tgagtttgta 301 gaactccgag ccctggtcat tgagatggtg ttggctacag atatggca (2) INFORMATION FOR SEQ ID NO:2608: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 2341 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO: 2608 1 gggccgccgt cggcgcgctg ggtgcgggaa gggggctctg gattcggtc cctccccttt 61 ttcctctgag tctcggaacg ctccagctct cagaccctct tcctcccagg taaaggccgg 121 gagaggaggg cgcatctctt ttccaggcac cccaccatgg gcaatgcctc caatgactcc 181 cagtctgagg actgcgagac gcgacagtgg cttcccccag gcgaaagccc agccatcagc 241 tccgtcatgt tctcggccgg ggtgctgggg aacctcatag cactggcgct gctggcgcgc 301 cgctggcggg gggacgtggg gtgcagcgcc ggccgcagga gctccctctc cttgttccac 361 gtgctggtga ccgagctggt gttcaccgac ctgctcggga cctgcctcat cagcccagtg 421 gtactggctt cgtacgcgcg gaaccagacc ctggtggcac tggcgcccga gagccgcgcg 481 tgcacctact tcgctttcgc catgaccttc ttcagcctgg ccacgatgct catgctcttc 541 gccatggccc tggagcgcta cctctcgatc gggcacccct acttctacca gcgccgcgtc 601 tcggcctccg ggggcctggc cgtgctgcct gtcatctatg cagtctccct gctcttctgc 661 tcgctgccgc tgctggacta tgggcagtac gtccagtact gccccgggac ctggtgcttc 721 atccggcacg ggcggaccgc ttacctgcag ctgtacgcca ccctgctgct gcttctcatt 781 gtctcggtgc tcgcctgcaa cttcagtgtc attctcaacc tcatccgcat gcaccgccga 841 agccggagaa gccgctgcgg accttccctg ggcagtggcc ggggcggccc cggggcccgc 901 aggagagggg aaagggtgtc catggcggag gagacggacc acctcattct cctggctatc 961 atgaccatca ccttcgccgt ctgctccttg cctttcacga tttttgcata tatgaatgaa 1021 acctcttccc gaaaggaaaa atgggacctc caagctctta ggtttttatc aattaattca 1081 ataattgacc cttgggtctt tgccatcctt aggcctcctg ttctgagact aatgcgttca 1141 gtcctctgtt gtcggatttc attaagaaca caagatgcaa cacaaacttc ctgttctaca 1201 cagtcagatg ccagtaaaca ggctgacctt tgaggtcagt agtttaaaag ttcttagtta 1261 tatagcatct ggaagatcat tttgaaattg ttccctggag aaatgaaaac agtgtgtaaa 1321 caaaatgaag ctgccctaat aaaaaggagt atacaaacat ttaagctgtg gtcaaggcta 1381 cagatgtgct gacaaggcac ttcatgtaaa gtgtcagaag gagctacaaa acctaccctc 1441 aatgagcatg gtacttggcc tttggaggaa caatcggctg cattgaagat ccagctgcct 1501 attgatttaa gctttcctgt tgaatgacaa agtatgtggt tttgtaattt gtttgaaacc 1561 ccaaacagtg actgtacttt ctattttaat cttgctacta ccgttataca catatagtgt 1621 acagccagac cagattaaac ttcatatgta atctctagga agtcaatatg tggaagcaac 1681 caagcctgct gtcttgtgat cacttagcga accctttatt tgaacaatga agttgaaaat 1741 cataggcacc ttttactgtg atgtttgtgt atgtgggagt actctcatca ctacagtatt 1801, actcttacaa gagtggactc agtgggttaa catcagtttt gtttactcat cctccaggaa 1861 ctgcaggtca agttgtcagg ttatttattt tataatgtcc atatgctaat agtgatcaag 1921 aagactttag gaatggttct ctcaacaaga aataatagaa atgtctcaag gcagttaatt 1981 ctcattaata ctcttattat cctatttctg ggggaggatg tacgtggcca tgtatgaagc 2041 caaatattag gcttaaaaac tgaaaaatct ggttcattct tcagatatac tggaaccctt 2101 ttaaagttga tattggggcc atgagtaaaa tagattttat aagatgactg tgttgtacca 2161 aaattcatct gtctatattt tatttagggg aacatggttt gactcatctt atatgggaaa 2221 ccatgtagca gtgagtcata tcttaatata tttctaaatg tttggcatgt aaatgtaaac 2281 tcagcatcaa aatatttcag tgaatttgca ctgtttaatc atagttactg tgtaaactca 2341 tctgaaatgt tacaaaaata aactataaaa ca WO 00/09525 PCT/US99/17712 EPI-109 779 (2) INFORMATION FOR SEQ ID NO:2609: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1321 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO: 2609 1 gggggcggca gggctgagcg gccggtgatg gggaccccac atcccaggca gtgccggcac 61 ccctggcgcc tgacatgagc ccttgcgggc ccctcaacct gagcctggcg ggcgaggcga 121 ccacatgcgc ggcgccctgg gtccccaaca cgtcggccgt gccgccgtcg ggcgcttcgc 181 ccgcgctgcc catcttctcc acgacgctgg gcgccgtgtc caacctgctg gcgctggcgc 241 tgctggcgca ggccgcgggc cgcctgcgac gccgccgctc ggccaccacc ttcctgctgt 301 tcgtggccag cctgctggcc accgacctgg cgggccacgt gatcccgggc gcgctggtgc 361 tgcgtctgta cactgcgggg cgcgctccgg ccggcggggc ctgccacttc ctgggcggct 421 gcatggtctt cttcggcctg tgcccgctgc tgctgggctg tggcatggcc gtggagcgct 481 gcgtgggcgt cacgcggccg ctgctccacg ccgcgcgggt ctcggtcgcc cgcgcgcgcc 541 tggcgctggc cgcggtggcc gcggtggcct tggccgtggc gctgctgccg ctggcgcgcg 601 tgggccgcta tgagctgcag tacccgggca cgtggtgctt catcggcctg ggtcccccgg 661 gcggctggcg ccaggcactg cttgctggcc tcttcgccag cctcggcctg gtcgcgctcc 721 tcgccgcgct ggtgtgcaac acgctcagcg gcctggccct gcatcgcgcc cgctggcgac 781 gccgctcccg acggcctccc ccggcctcag gccccgacag ccggcgtcgc tggggggcgc 841 acggaccccg ctcggcctcc gcctcgtccg cctcgtccat cgcttcggcc tccaccttct 901 ttggcggctc tcggagcagc ggctcggcac gcagagctcg cgcccacgac gtggagatgg 961 tgggccagct tgtcggtatc atggtggtgt cgtgcatctg ctggagccca atgctggtgt 1021 tggtggcgct ggccgtcggc ggctggagct ctacctccct gcagcggcca ctgttcctgg 1081 ccgtgcgcct tgcctcctgg aaccagatcc tggacccttg ggtgtacatc ctactgcgcc 1141 aggccgtgct gcgccaactg cttcgcctct tgcccccgag ggccggagcc aagggcggcc 1201 ccgcggggct gggcctaaca ccgagcgcct gggaggccag ctcgctgcgc agctcccggc 1261 acagcggcct cagccacttc taagcacaac cagaggccca acgactaagc cagcccaccc 1321 tgggctgggc ccaggtgcgc ggcgcagagc ctttgggaat aaaaagccat tctgcg (2) INFORMATION FOR SEQ ID NO:2610: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1021 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2610 1 atgggcaatg cctccaatga ctcccagtct gaggactgcg agacgcgaca gtggcttccc 61 ccaggcgaaa gcccagccat cagctccgtc atgttctcgg ccggggtgct ggggaacctc 121 atagcactgg cgctactggc gcgccgctgg cggggggacg tggggtgcag cgccggccgc 181 aggagctccc tctccttgtt ccacgtgctg gtgaccgagc tggtgttcac cgacctgctc 241 gggacctgcc tcatcagccc agtggtactg gcttcgtacg cgcggaacca gaccctggtg 301 gcactggcgc ccgagagccg cgcgtgcacc tacttcgctt tcgccatgac cttcttcagc 361 ctggccacga tgctcatgct cttcgccatg gccctggagc gctacctctc gatcgggcac 421 ccctacttct accagcgccg cgtctcgcgc tccgggggcc tggccgtgct gcctgtcatc 481 tatgcagtct ccctgctctt ctgctcgctg ccgctgctgg actatgggca gtacgtccag 541 tactgccccg ggacctggtg cttcatccgg cacgggcgga ccgcttacct gcagctgtac 601 gccaccctgc tgctgcttct cattgtctcg gtgctcgcct gcaacttcag tgtcattctc 661 aacctcatcc gcatgcaccg ccgaagccgg agaagccgct gcggaccttc cctgggcagt 721 ggccggggcg gccccggggc ccgcaggaga ggggaaaggg tgtccatggc ggaggagacg 781 gaccacctca ttctcctggc tatcatgacc atcaccttcg ccgtctgctc cttgcctttc 841 acgatttttg catatatgaa tgaaacctct tcccgaaagg aaaaatggga cctccaagct 901 cttaggtttt tatcaattaa ttcaataatt gacccttggg tctttgccat ccttaggcct 961 cctgttctga gactaatgcg ttcagtcctc tgttgtcgga tttcattaag aacacaagat 1021 gcaacacaaa cttcctgttc tacacagtca gatgccagta aacaggctga cctttga (2) INFORMATION FOR SEQ ID NO:2611: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1201 base pairs (B) TYPE: nucleic acid (C) STBANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO: 2611 1 ctgcagatgg gaagaggttt ttccaggaat ttaaattgtg caataaggcc acacaatctt 61 acttaaaaaa aatggtgaag gggttttaat tacaccatga agtttacaa ttttttaggt 121 ttttagttct ggttttagaa aacagagtag aaggatgaac agagaaaaac tcaccatta 181 gacaagaagt caaaatgatt ctaagggccg cgcaaacagg cctcccaaga attaatcatg 241 aggtggtgct tggagaattc ctttactcca gtgactttga aacccccttc tcactctcca WO 00/09525 PCT/US99/17712 EPI-109 780 301 ctagtctttc aaaggattca tggtgaattg ggtctaacga gtataacacg gccggccgaa 361 cgatgaagct cacgctaccc tttcagggcg gagaagttcc caggagaaag aatggagaaa 421 aagatcgcag ttaggcagtc ctcccaacct caccaaggct ccacctctct ccaaagccgc 481 aacgtgctgc cacctgcgcc gggagaggct gcaatcactg tctcctcctc tttctttctc 541 tttttttttt tttctttttt gcctggggtg cccgaccaag cgcagccgca gtctgggcac 601 tgccaactga ctccaactcc ttttatggtg agaggatgga ttcttCgtta tttccccgcc 661 caatctggta cccacccacc cacccaccca ccacgtccgc tgggcgcacc caagtctaac 721 cccggggcgc acgccgtagc gcagacaccg tatttctcct cctttcZCgg ccaaccctag 781 gtagaatcct aaaacaactg ccctctcttc cacgatctag atgttgcggc ccgcggacag 841 gaggttcaag aaatagtaca ctccgagcgg caggcagcga gagcggaaac ggtcgccggt 901 ttcagtggtg gccccactgg aagccgagtt caggagcggc taagcccgc cggggaaagc 961 accggggctt cccagggtct cctccgagtt cccactccgc acctccgagg gcgtgaaaac 1021 cacgggagcc gcccgccccg cgcgcccagc cccgccccag cccagacacc gccccccgcc 1081 agtcttccct gcggcgccca gggaggacgc cgtccgcccc cttccaatcc ggccaatggg 1141 cgcccgggca gcgcgcggtt tgcctccgcc tccgccaggg aaacttggag gaggagaaaa 1201 gtttgtacag agggtggaaa ggccgcagca cgcgagctcc a (2) INFORMATION FOR SEQ ID NO:2612: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 2101 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO: 2612 1 agcccggcag cccgagagga agatgaacag ccccaggcca gagccztgc gagagtggac 61 cccgagccgc ccccaggtag ccaagagcgg cctcagcggc agccgcaaac tccagtagcc 121 gcccgtgctg cccgtgctgg ggcggagggc agccagagct ggggaccaag gctccgcgcc 181 acctgggcac agcctcacac ctgaacgctg tcctcccgca gacgagaccg gcgggcactg 241 caaagctggg actcgtcttt gaaggaaaaa aaatagcgag taagaaatcc agcaccattc 301 ttcactgacc catcccgctg cacctcttgt ttcccaagtt tttgaaagct ggcaactctg 361 acctcggtgt ccaaaaatcg acagccactg agaccggctt tgagaagccg aagatttggc 421 agtttccaga ctgagcagga caaggtgaaa gcaggttgga ggcgggtcca ggacatctga 481 gggctgaccc tgggggctcg tgaggctgcc accgctgctg ccgctacagg tgagatggcg 541 ttgggctgac gttggggtca acgggtagag aacgagggat gccgccctcg ccgaagagag 601 ccaagagggg aagagcgcgc tctccaaatt gcttttgtaa cttgttttca gtgagcattt 661 tattgattca gaatctatcg agaatagcac tagcgagcta ctttcccctt gagatgggtc 721 ttattcatct tggcaatgga gtgagttgga ttgtggggag gaagaggaat gggaaaatca 781 gtttataaat attaatgtca gccaagagtg tgctgttggc aggacgtatc gcgagcctgg 841 agattttggt ggccgcagtt ggtaagtggc tacaatccag aaagtaggat cgagttgctc 901 cccttgtctt atcagtgtat cgtttctcgg gcgcgggtct aacaccttac aagtggtaat 961 ttccgctcac ggcagctttg tctctcttct accatcccca gacccagcct tgcactccaa 1021 ggctgcgcac cgccagccac tatcatgtcc actcccgggg tcaattcgtc cgcctccttg 1081 agccccgacc ggctgaacag cccagtaacc atcccggcgg tgatgttcat cttcggggtg 1141 gtgggcaacc tggtggccat cgtggtgctg tgcaagtcgc gcaaggagca gaaggagacg 1201 accttctaca cgctggtatg tgggctggct gtcaccgacc tgttgggcac tttgttggtg 1261 agcccggtga ccatcgccac gtacatgaag ggccaatggc ccgggggcca gccgctgtgc 1321 gagtacagca ccttcattct gctcttcttc agcctgtccg gcctcagcat catctgcgcc 1381 atgagtgtcg agcgctacct ggccatcaac catgcctatt tctacagcca ctacgtggac 1441 aagcgattgg cgggcctcac gctctttgca gtctatgcgt ccaacgtgct cttttgcgcg 1501 ctgcccaaca tgggtctcgg tagctcgcgg ctgcagtacc cagacacctg gtgcttcatc 1561 gactggacca ccaacgtgac ggcgcacgcc gcctactcct acatgzacgc gggcttcagc 1621 tccttcctca ttctcgccac cgtcctctgc aacgtgcttg tgtgcggcgc gctgctccgc 1681 atgcaccgcc agttcatgcg ccgcacctcg ctgggcaccg agcagcacca cgcggccgcg 1741 gccgcctcgg ttgcctcccg gggccacccc gctgcctccc cagccttgcc gcgcctcagc 1801 gactttcggc gccgccggag cttccgccgc atcgcgggcg ccgagatcca gatggtcatc 1861 ttactcattg ccacctccct ggtggtgctc atctgctcca tcccgctcgt ggtgagtgac 1921 cgggggtggg gccctactcg gcctttttct cgcatccacc tcccgcgtcc attccccgct 1981 ccctgttttc cctctgagtc cttgggagtg aacgtgtcgc ctttaggtcg gggctgggat 2041 tcccacactg tttctcagag gaggcccaac ccctctttgg aagtcccaac cctaacgcga 2101 tttagcaggt gctttggccc tacatccccc agtttatgtt tcccgaagg ctgg (2) INFORMATION FOR SEQ ID NO:2613: )i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 781 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (0) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2613 1 agcccatgac tggtttttct gaggcttatt atgtagcttc ctcttztcct ggaacttgtt WO 00/09525 PCT/US99/17712 EPI-109 781 61 accagaaatg aaggcagctt cctaatattg ataaggtaga catagcattt atatgttttc 121 ccaattgatt aatgatgaaa tctaaatgtg cgactcactt atgcaggtgc gagtattcgt 181 caaccagtta tatcagccaa gtttggagcg agaagtcagt aaaaatccag atttgcaggc 241 catccgaatt gcttctgtga accccatcct agacccctgg atatatatcc tcctgagaaa 301 gacagtgctc agtaaagcaa tagagaagat caaatgcctc ttctgccgca ttggcgggtc 361 ccgcagggag cgctccggac agcactgctc agacagtcaa aggacatctt ctgccatgtc 421 aggccactct cgctccttca tctcccggga gctgaaggag atcagcagta catctcagac 481 cctcctgcca gacctctcac tgccagacct cagtgaaaat ggccttggag gcaggaattt 541 gcttccaggt gtgcctggca tgggcctggc ccaggaagac accacctcac tgaggacttt 601 gcgaatatca gagacctcag actcttcaca gggtcaggac tcagagagtg tgttactggt 661 ggatgaggct ggtggaagcg gcagggcagg gcctgcccct aaggggagct ccctgcaagt 721 cacatttccc agtgaaacac tgaacttatc agaaaaatgt atataatagg caaggaaaga 781 aatacagtac tgtttctgga cccttataaa atcctgtgca atagacacat acatgtcaca (2) INFORMATION FOR SEQ ID NO:2614: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 8766 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO: 2614 1 gggccgccgt cggcgcgctg ggtgcgggaa gggggctctg gatttcggtc cctccccttt 61 ttcctctgag tctcggaacg ctccagctct cagaccctct tcctcccagg taaaggccgg 121 gagaggaggg cgcatctctt ttccaggcac cccaccatgq gcaatgcctc caatgactcc 181 cagtctgagg actgcgagac gcgacagtgg cttcccccag gcgaaagccc agccatcagc 241 tccgtcatgt tctcggccgg ggtgctgggg aacctcatag cactggcgct gctggcgcgc 301 cgctggcggg gggacgtggg gtgcagcgcc ggccgcagga gctccctctc cttgttccac 361 gtgctggtga ccgagctggt gttcaccgac ctgctcggga cctgcctcat cagcccagtg 421 gtactggctt cgtacgcgcg gaaccagacc ctggtggcac tggcgcccga gagccgcgcg 481 tgcacctact tcgctttcgc catgaccttc ttcagcctgg ccacgatgct catgctcttc 541 gccatggccc tggagcgcta cctctcgatc gggcacccct acttctacca gcgccgcgtc 601 tcggcctccg ggggcctggc cgtgctgcct gtcatctatg cagtctccct gctcttctgc 661 tcgctgccgc tgctggacta tgggcagtac gtccagtact gccccgggac ctggtgcttc 721 atccggcacg ggcggaccgc ttacctgcag ctgtacgcca ccctgctgct gcttctcatt 781 gtctcggtgc tcgcctgcaa cttcagtgtc attctcaacc tcatccgcat gcaccgccga 841 agccggagaa gccgctgcgq accttccctg ggcagtggcc ggggcggccc cggggcccgc 901 aggagagggg aaagggtgtc catggcggag gagacggacc acctcattct cctggctatc 961 atgaccatca ccttcgccgt ctgctccttg cctttcacga tttttgcata tatgaatgaa 1021 acctcttccc gaaaggaaaa atgggacctc caagctctta ggtttttatc aattaattca 1081 ataattgacc cttgggtctt tgccatcctt aggcctcctg ttctgagact aatgcgttca 1141 gtcctctgtt gtcggatttc attaagaaca caagatgcaa cacaaacttc ctgttctaca 1201 cagtcagatg ccagtaaaca ggctgacctt tgaggtcagt agtttaaaag ttcttagtta 1261 tatagcatct ggaagatcat tttgaaattg ttccctggag aaatgaaaac agtgtgtaaa 1321 caaaatgaag ctgccctaat aaaaaggagt atacaaacat ttaagctgtg gtcaaggcta 1381 cagatgtgct gacaaggcac ttcatgtaaa gtgtcagaag gagctacaaa acctaccctc 1441 aatgagcatg gtacttggcc tttggaggaa caatcggctg cattgaagat ccagctgcct 1501 attgatttaa gctttcctgt tgaatgacaa agtatgtggt tttgtaattt gtttgaaacc 1561 ccaaacagtg actgtacttt ctattttaat cttgctacta ccgttataca catatagtgt 1621 acagccagac cagattaaac ttcatatgta atctctagga agtcaatatg tggaagcaac 1681 caagcctgct gtcttgtgat cacttagcga accctttatt tgaacaatga agttgaaaat 1741 cataggcacc ttttactgtg atgtttgtgt atgtgggagt actctcatca ctacagtatt 1801 actcttacaa gagtggactc agtgggttaa catcagtttt gtttactcat cctccaggaa 1861 ctgcaggtca agttgtcagg ttatttattt tataatgtcc atatgctaat agtgatcaag 1921 aagactttag gaatggttct ctcaacaaga aataatagaa atgtctcaag gcagttaatt 1981 ctcattaata ctcttattat cctatttctg ggggaggatg tacgtggcca tgtatgaagc 2041 caaatattag gcttaaaaac tgaaaaatct ggttcattct tcagatatac tggaaccctt 2101 ttaaagttga tattggggcc atgagtaaaa tagattttat aagatgactg tgttgtacca 2161 aaattcatct gtctatattt tatttagggg aacatggttt gactcatctt atatgggaaa 2221 ccatgtagca gtgagtcata tcttaatata tttctaaatg tttggcatgt aaatgtaaac 2281 tcagcatcaa aatatttcag tgaatttgca ctgtttaatc atagttactg tgtaaactca 2341 tctgaaatgt tacaaaaatta aactataaaa ca 1 gggggcggca gggctgagcg gccggtgatg gggaccccac atcccaggca gtgccggcac 61 ccctggcgcc tgacatgagc ccttgcgggc ccctcaacct gagcctggcg ggcgaggcga 121 ccacatgcgc ggcgccctgg gtccccaaca cgtcggccgt gccgccgtcg ggcgcttcgc 181 ccgcgctgcc catcttctcc atgacgctgg gcgccgtgtc caacctgctg gcgctggcgc 241 tgctggcgca ggccgcgggc cgcctgcgac gccgccgctc ggccaccacc ttcctgctgt 301 tcgtggccag cctgctggcc accgacctgg cgggccacgt gatcccgggc gcgctggtgc 361 tgcgtctgta cactgcgggg cgcgctccgg ccggcggggc ctgccacttc ctgggcggct 421 gcatggtctt cttcggcctg tgcccgctgc tgctgggctg tggcatgcc gctggagcgct WO 00/09525 PCT/US99/17712 EPI-109 782 481 gcgtgggcgt cacgcggccg ctgctccacg ccgcgcgggt ctcggtcgcc cgcgcgcgcc 541 tggcgctggc cgcggtggcc gcggtggcct tggccgtggc gctgctgccg ctggcgcgcg 601 tgggccgcta tgagctacag tacccgggca cgtggtgctt catcggcctg ggtcccccgg 661 gcggctggcg ccaggcactg cttgctggcc tcttcgccag cctcggcctg gtcgcgctcc 721 tcgccgcgct ggtgtgcaac acgctcagcg gcctggccct gcatcgcgcc cgctggcgac 781 gccgctcccg acggcctccc ccggcctcag gccccgacag ccggcgtcgc tggggggcgc 841 acggaccccg ctcggcctcc gcctcgtccg cctcgtccat cgcttcggcc tccaccttct 901 ttggcggctc tcggagcagc ggctcggcac gcagagctcg cgcccacgac gtggagatgg 961 tgggccagct tgtcggtatc atggtggtgt cgtgcatctg ctggagccca atgctggtgt 1021 tggtggcgct ggccgtcggc ggctggagct ctacctccct gcagcggcca ctgttcctgg 1081 ccgtgcgcct tgcctcctgg aaccagatcc tggacccttg ggtgtacatc ctactgcgcc 1141 aggccgtgct gcgccaactg cttcgcctct tgcccccgag ggccggagcc aagggcggcc 1201 ccgcggggct gggcctaaca ccgagcgcct gggaggccag ctcgctgcgc agctcccggc 1261 acagcggcct cagccacttc taagcacaac cagaggccca acgactaagc cagcccaccc 1321 tgggctgggc ccaggtgcgc ggcgcagagc ctttgggaat aaaaagccat tctgcg 1 atgggcaatg cctccaatga ctcccagtct gaggactgcg agacgcgaca gtggcttccc 61 ccaggcgaaa gcccagccat cagctccgtc atgttctcgg ccggggtgct ggggaacctc 121 atagcactgg cgctgctggc gcgccgctgg cggggggacg tggggtgcag cgccggccgc 181 aggagctccc tctccttgtt ccacgtgctg gtgaccgagc tggtgttcac cgacctgctc 241 gggacctgcc tcatcagccc agtggtactg gcttcgtacg cgcggaacca gaccctggtg 301 gcactggcgc ccgagagccg cgcgtgcacc tacttcgctt tcgccatgac cttcttcagc 361 ctggccacga tgctcatgct cttcgccatg gccctggagc gctacctctc gatcgggcac 421 ccctacttct accagcgccg cgtctcgcgc tccgggggcc tggccgtgct gcctgtcatc 481 tatgcagtct ccctgctctt ctgctcgctg ccgctgctgg actatgggca gtacgtccag 541 tactgccccg ggacctggtg cttcatccgg cacgggcgga ccgcttacct gcagctgtac 601 gccaccctgc tgctgcttct cattgtctcg gtgctcgcct gcaacttcag tgtcattctc 661 aacctcatcc gcatgcaccg ccgaagccgg agaagccgct gcggaccttc cctgggcagt 721 ggccggggcg gccccggggc ccgcaggaga ggggaaaggg tgtccatggc ggaggagacg 781 gaccacctca ttctcctggc tatcatgacc atcaccttcg ccgtctgctc cttgcctttc 841 acgatttttg catatatgaa tgaaacctct tcccgaaagg aaaaatggga cctccaagct 901 cttaggtttt tatcaattaa ttcaataatt gacccttggg tctttgccat ccttaggcct 961 cctgttctga gactaatgcg ttcagtcctc tgttgtcgga tttcattaag aacacaagat 1021 gcaacacaaa cttcctgttc tacacagtca gatgccagta aacaggctga cctttga 1 ctgcagatgg gaagaggttt ttccaggaat ttaaattgtg caataaggcc acacaatctt 61 acttaaaaaa aatggtgaag gggttttaat tacaccatga agttttacaa ttttttaggt 121 ttttagttct ggttttagaa aacagagtag aaggattaac agagaaaaac ttcaccatta 181 gacaagaagt caaaatgatt ctaagggccg cgcaaacagg ctttccaaga attaatcatg 241 aggtggtgct tggagaattc ctttactcca gtgactttga aacccccttc tcactctcca 301 ctagtctttc aaaggattca tggtgaattg ggtctaacga gtataacacg gccggccgaa 361 cgatgaagct cacgctaccc tttcagggcg gagaagttcc caggaggaag aatggagaaa 421 aagatcgcag ttaggcagtc ctcccaacct caccaaggct ccacctctct ccaaagccgc 481 aacgtgctgc cacctgcgcc gggagaggct gcaatcactg tctcctcctc tttctttctc 541 tttttttttt tttctttttt gcctggggtg cccgaccaag cgcagccgca gtctgggcac 601 tgccaactga ctccaactcc ttttatggtg agaggatgga ttcttcgtta tttccccgcc 661 caatctggta cccacccacc cacccaccca ccacgtccgc tgggcgcacc caagtctaac 721 cccggggcgc acgccgtagc gcagacaccg tatttctcct cctttctcgg ccaaccctag 781 gtagaatcct aaaacaactg ccctctcttc cacgatctag atgttgcggc ccgcggacag 841 gaggttcaag aaatagtaca ctccgagcgg caggcagcga gagcggaaac ggtcgccggt 901 ttcagtggtg gccccactgg aagccgagtt caggagcggc taagcgtcgc cggggaaagc 961 accggggctt cccagggtct cctccgagtt cccactccgc acctccgagg gcgtgaaaac 1021 cacgggagcc gcccgccccg cgcgcccagc cccgccccag cccagacacc gccccccgcc 1081 agtcttccct gcggcgccca gggaggacgc cgtccgcccc cttccaatcc ggccaatggg 1141 cgcccgggca gcgcgcggtt tgcctccgcc tccgccaggg aaacttggag gaggagaaaa 1201 gtttgtacag agggtggaaa ggccgcagca cgcgagctcc a 1 agcccggcag cccgagagga agatgaacag ccccaggcca gagcctctgc gagagtggac 61 cccgagccgc ccccaggtag ccaggagcgg cctcagcggc agccgcaaac tccagtagcc 121 gcccgtgctg cccgtgctgg ggcggagggc agccagagct ggggaccaag gctccgcgcc 181 acctgggcac agcctcacac ctgaacgctg tcctcccgca gacgagaccg gcgggcactg 241 caaagctggg actcgtcttt gaaggaaaaa aaatagcgag taagaaatcc agcaccattc 301 ttcactgacc catcccgctg cacctcttgt ttcccaagtt tttgaaagct ggcaactctg 361 acctcggtgt ccaaaaatcg acagccactg agaccggctt tgagaagccg aagatttggc 421 agtttccaga ctgagcagga caaggtgaaa gcaggttgga ggcgggtcca ggacatctga 481 gggctgaccc tgggggctcg tgaggctgcc accgctgctg ccgctacagg tgagatggcg 541 ttgggctgac gttggggtca acgggtagag aacgagggat gccgccctcg ccgaagagag 601 ccaagagggg aagagcgcgc tctccaaatt gcttttgtaa cttgttttca gtgagcattt 661 tattgattca gaatctatcg agaatagcac tagcgagcta ctttcccctt gagatgggtc 721 ttattcatct tggcaatgga gtgagttgga ttgtggggag gaagaggaat gggaaaatca 781 gtttataaat attaatgtca gccaagagtg tgctgttggc aggacgtatc gcgagcctgg WO 00/09525 PCT/US99/17712 EPI-109 783 841 agattttggt ggccgcaactt ggtaagtggc tacaatccag aaagtaggat cgagttgctc 901 cccttgtctt atcagtgtat cgtttctcgg gcgcgggtct aacaccttac aagtggtaat 961 ttccgctcac ggcagctt.g tctctcttct accatcccca gacccagcct tgcactccaa 1021 ggctgcgcac cgccagccac tatcatgtcc actcccgggg tcaattcgtc cgcctccttg 1081 agccccgacc ggctgaacag cccagtaacc atcccggcgg tgatgttcat cttcggggtg 1141 gtgggcaacc tggtggccat cgtggtgctg tgcaagtcgc gcaaggagca gaaggagacg 1201 accttctaca cgctggtatg tgggctggct gtcaccgacc tgttgggcac tttgttggtg 1261 agcccggtga ccatcgccac gtacatgaag ggccaatggc ccgggggcca gccgctgtgc 1321 gagtacagca ccttcatrct gctcttcttc agcctgtccg gcctcagcat catctgcgcc 1381 atgagtgtcg agcgctacct ggccatcaac catgcctatt tctacagcca ctacgtggac 1441 aagcgattgg cgggcctcac gctctttgca gtctatgcgt ccaacgtgct cttttgcgcg 1501 ctgcccaaca tgggtctcgg tagctcgcgg ctgcagtacc cagacacctg gtgcttcatc 1561 gactggacca ccaacgtgac ggcgcacgcc gcctactcct acatgtacgc gggcttcagc 1621 tccttcctca ttctcgccac cgtcctctgc aacgtgcttg tgtgcggcgc gctgctccgc 1681 atgcaccgcc agttcatgcg ccgcacctcg ctgggcaccg agcagcacca cgcggccgcg 1741 gccgcctcgg ttgcctcccg gggccacccc gctgcctccc cagccttgcc gcgcctcagc 1801 gactttcggc gccgccggag cttccgccgc atcgcgggcg ccgagatcca gatggtcatc 1861 ttactcattg ccacctccct ggtggtgctc atctgctcca tcccgctcgt ggtgagtgac 1921 cgggggtggg gccctactcg gcctttttct cgcatccacc tcccgcgtcc attccccgct 1981 ccctgttttc cctctgagtc cttgggagtg aacgtgtcgc ctttaggtcg gggctgggat 2041 tcccacactg tttctcagag gaggcccaac ccctctttgg aagtcccaac cctaacgcga 2101 tttagcaggt gctttggccc tacatccccc agtttatgtt tcccggaagg ctgg 1 agcccatgac tggtttttct gaggcttatt atgtagcttc ctcttttcct ggaacttgtt 61 accagaaatg aaggcagctt cctaatattg ataaggtaga catagcattt atatgttttc 121 ccaattgatt aatgatgaaa tctaaatgtg cgactcactt atgcaggtgc gagtattcgt 181 caaccagtta tatcagccaa gtttggagcg agaagtcagt aaaaatccag atttgcaggc 241 catccgaatt gcttctgtga accccatcct agacccctgg atatatatcc tcctgagaaa 301 gacagtgctc agtaaagcaa tagagaagat caaatgcctc ttctgccgca ttggcgggtc 361 ccgcagggag cgctccggac agcactgctc agacagtcaa aggacatctt ctgccatgtc 421 aggccactct cgctccttca tctcccggga gctgaaggag atcagcagta catctcagac 481 cctcctgcca gacctctcac tgccagacct cagtgaaaat ggccttggag gcaggaattt 541 gcttccaggt gtgcctggca tgggcctggc ccaggaagac accacctcac tgaggacttt 601 gcgaatatca gagacctcag actcttcaca gggtcaggac tcagagagtg tgttactqgt 661 ggatgaggct ggtggaagcg gcagggcagg gcctgcccct aaggggagct ccctgcaagt 721 cacatttccc agtgaaacac tgaacttatc agaaaaatgt atataatagg caaggaaaga 781 aatacagtac tgtttctgga cccttataaa atcctgtgca atagacacat acatgtcaca (2) INFORMATION FOR SEQ ID NO:2615: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 4861 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO: 2615 1 aagcttcctg tacctggaat attaatattt tatttcagac ttgggaaatt ttcagctagc 61 aatctttaaa tatgctttct gacccccttt tcctctattt tctccttctt aaactactgt 121 aatgtgaaca ttagctctct tttttaattt ttaatttaat ttttgttttt attttttgag 181 atgcagtctc actctgtcac ccaggctgga gtgcagtggc atgatctcag ctcactgcaa 241 cctttgcctt ctaggttga a gagattctgc tgcctcagtc tccccatgag ctgggattac 301 agcatgtgcc acaatccctg gctaattttt ttgtattttt agtagagact gggtttcacc 361 atgttggtca ggctggtctt gactcctgac ctcaggtgat ccactcacct tggcctccca 421 aagcgctggg attatggcat gagccactga gtctggctga atgttagctc tcttgatgct 481 gtcccataaa tcttgtaggc tttcatcatt tcttttcatt cttttttctc ctctcactgt 541 atattttcaa aaacctgtct tcagttcaca gattctttct tctgcttgat caagtctgct 601 actggtgatt tctactgcat ttctcacttc attcattata tttttcagct ccaatttctt 661 ttatgatttc aatctttctg ttacatttct tatgttgtgc atttattgtt tctctgattt 721 caccaaattg tttctctgtg tttgcttcaa agtaactgag cttctttaaa aacaattatc 781 ttgaatccat tgtcaggcca tttgtagtac tccatttctt ttgggtcagc tactgggaaa 841 ttattgtgtt tcttaggtgg tgatatttta atttgggttt tcatgtttct tgctgcctta 901 cactgctgtc tgagcatctg gtggatctgc cccaatttca ggctgtatgg gctgactttg 961 gtggagaaat accttcttat gtggaataat gcgaggatgc tggctgggtg ggatgcaaaa 1021 gttctgactt cagtaggggc aaagctgtgt ggtctccatg cagatctgtc agctgaggtt 1081 ggtgttagtg aatactacag ggatccttag aggccaacac tgcgggtatc tacagtggca 1141 atgaggctgt tgaggttttc aattgtgaca agtcctccat atctcttttt ttccccacct 1201 gggaagtcat gactgaggac atccctcttg gaattaggtc taacttgcag gcctgctcct 1261 ggtggtggtg acactggtgt ctgatgaaca gtgcccatgg agtggccaag agccaaggcc 1321 tgaagcatgg gcatgcatgg agggaccaca gcaccagatt caattgtagc aatggtacca 1381 gtgcccaagg cacaggcata cttactatca cattgataat ggtgtgtaaa atgcaggtac WO 00/09525 PCT/US99/17712 EPI-109 784 1441 ttataaagca gctaaggagc cagggacttt actgcatgca tacgcagagc tacagtggct 1501 ccaggatcca gggtgtgggc tagctctcct tggtggctga gctggtgact agagcatgga 1561 caggcacaga gaaaccttga ctctaggacc cagggtgttc actagctcac tatagtggtg 1621 gctctggtgt tggaggtgtg ggtgtgtgta gtacagcctc agagacaggg tctggagcgc 1681 aggtgtgcac attactacag cagctctgga gttgagaata tgggttacct ttctacagtg 1741 gctgaactag tgtctggagc aaagactttc acagagagaa cttggcttgg ggtcccaggg 1801 tgagatctag ttcacaacag cagtgactcc agtgtctgag acatgaggag gtgcactgca 1861 gccacagagc cacagtccag agtgtgaata tctgtagagc agccacaact tttggggatc 1921 aggaacacac atagaattgt gagaggtggt aaccctggcc ccagtcctgg cgagtgcaac 1981 aatagctgct tcttggtgag ggggtgtgag gggtagtgca actgtgtttc cctttttagc 2041 atcctgctat gggaatggct gttggacaaa agatgccagt gtcctcgtg gagcaggaca 2101 ctgggggcct cagtggctct gtgtcacatg actgacacag atagcctaca aatttcttta 2161 ttcgtagcta tctcctggtg tctcatatat gccagtctca ccggtgattc ttctacatga 2221 atattctttc ttttctccat tgtgttgttc caaattcttt aacaggctct tgagccccat 2281 cccccaactc cccacccttg tgagggctat tttggtttgt gtataactgt ctatgtttgt 2341 ttttttgttg gggcataagg ctgacatctc ctactccacc atcttgctaa tgtcacctgc 2401 ataqgaatct ttttatgctt tccttatatt cactaaaatt taacaatatc aaacttaaaa 2461 acatatgatc aattgaactt attaatatca aacttattat aaataagaaa ctaccaggct 2521 gggcatggtg gctcatgcct gtaatcccaa cattttggga ggctgaggtg aaaggatcac 2581 ttgagcccag gaattcaaga ccagcctggg aaatatagag agaccctatc tctagagatt 2641 ttttttttta attagccagt agtgatggca cacatctata gtcccagcta ctcaggaggc 2701 tgaggtggga gaattgcttg agcccaggag gtcaaggctg cagcaagcag taatcatgcc 2761 actgcactcc agcctgggcc gcagagtgag accctgtctc aaaaaaagaa cctactagtc 2821 tacataccac acttcttcat ccccatctga gactatatat attttttcta acatgaggca 2881 atgccaaaaa gaggagctgg tgagtgaaag taagaacaga aagacatgga ggcaagtctt 2941 atagaataat agccaacact taaacttaca cttaacagcg tgataggtat tgttccaaac 3001 acattaaatt catttaatgg tccttacatg tctatgtatt tggtgattat tatccttatt 3061 attcacattg ctgagtgtat tattctgttc tcatgatgct gatagagaca tacccgagac 3121 tggataactt attaaaaaaa aaaaggttta atggactcac agttccacgt ggatggggag 3181 tcctcacaat catggtagaa agcaaaagac acgtcttaca tggcagcagg gaagagagag 3241 aaatgagaac caaacaaaag gggtttcccc ttataaaacc atcagctctc atgcgactta 3301 ttcactacca tgagaacagt atgggggaaa ccacccccat gattcaatga tctaccaggt 3361 gcctcccaca acctgtggga attatgggag ctacaattcc agatgagatt tgggtgggga 3421 cacagccaaa ccacatcact gaggaaactg agttataggg agattagtaa cgcccaacac 3481 agctggtagg tggtggagcc aggcagtctg actctagggt ctggacrctg aactgcatca 3541 tgctgccaag aagttcctca ttttttcctc tctctaagtt tcccttattc ccctacagtc 3601 attccttcaa cagcatttcc ttcaccatct tttctacttc tactatataa ttaatttttt 3661 cttcttggtc ccaaattcca acgtgcaaat gcagccttat ataccctaat tcatctttac 3721 ctttagactt tcttccaatg tttctacttc attccatttt aaatttatcc atgagatgcc 3781 tatttacaag ctgtaaccat catgaagtga atgaagaata atacctacta ctgtacaata 3841 gaattccaag agtataaata ggagttatgg ctttctgact tgaaactaaa tacttgatac 3901 ttgattttgc tgtctgagat caatctgaaa agtaataata atcactaaca tttgttgagc 3961 atcaattgtg ggccaagtgt catttcaatc actctgtaca tattaactca tttcatccta 4021 caacaacccg gtgaggcaag ttctgttatt ctgttttaca gttgaggaaa cagaggcata 4081 gagagcttaa gtagtttgcc cagtagatag ccagaagagg agccaggatg ggtctcgggc 4141 agtttaacag cacagctgaa gtcttaacca ctatgccaac agctttttgg tcctacacat 4201 cccatgggaa gaggaaaata aaaaggtatc tatttgtata cctttttatt tctgatataa 4261 gaagcagaat tcctttcaca tgacctatgt ctatttaata cgtcattttg aaacttacca 4321 ataaaatttc ccaagcgcca gaaaactgtt agtggctttt tccattcttc tctatttttt 4381 tttgtgctac taattttgct tctttccctc agaaggctgc cggaatagta aacattcact 4441 gacatgtcat aattactgga aaatgggcac tggaaaatca cattgtaatt aattcaaagc 4501 atgttttcca aatgtactac tttaaattgg agcttatatc ataatccaag gaaacctttg 4561 tgtgtgtact gttcccacat tgctcagcct gggatatcca ggagtaattc accttgcgcc 4621 tgcctccaga ccatcttcca tggaaggggg tgaccccttg cctcttggca accactattt 4681 ctaagctgcc aacattactc ttgcattatc aacattctaa cttcatggga agggctgtgg 4741 tgagtttctg gaatgtgaat aggaagttgt ttttctaaac agcctacac tgaggggagg 4801 cagtgagact gtaagcagtc tgggttgggc agaaggcaga aaaccagcag agtcacagag 4861 gagatg (2) INFORMATION FOR SEQ ID NO:2616: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 961 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2616 1 gtcgaggatc cctaaagtcc tttgaagctt tcatattctg taacttttgt gccaagaagg 61 ccttacagtg agatgggatc ccagtattta ttgagtttcc tcattcataa aatggggata 121 ataatagtaa atgagttgac acgcgctaag acagtggaat agtggctggc acagataagc WO 00/09525 PCT/US99/17712 EPI-109 785 181 cctcggtaaa tggtagccaa taatgataga gtatgctgta agatatcttt ctctccctct 241 gcttctcaac aagtctctaa tcaattattc cactttataa acaaggaaat agaactcaaa 301 gacattaagc acttttccaa aggtcgctta gcaagtaaat gggagagacc ctatgaccag 361 gatgaaagca agaaattccc acaagaggac tcattccaac tcatatcttg tgaaaaggtt 421 cccaatgccc agctcagatc aactgcctca atttacagtg tgagtgtgct cacctccttt 481 ggggactgta tatccagagg accctcctca ataaaacact ttataaataa catccttcca 541 tggatgaggg aaaggaggta agatctgtaa tgaataagca ggaactttga agactcagtg 601 actcagtgag taataaagac tcagtgactt ctgatcctgt cctaactgcc actccttgtt 661 gtcccaagaa agcggcttcc tgctctctga ggaggacccc ttccctggaa ggtaaaacta 721 aggatgtcag cagagaaatt tttccaccat tggtgcttgg tcaaagagga aactgatgag 781 ctcactctag atgagagagc agtgagggag agacagagac tcgaatttcc ggagctattt 841 cagttttctt ttccgttttg tgcaatttca cttatgatac cggccaatgc ttggttgcta 901 ttttggaaac tccccttagg ggatgcccct caactggccc tataaagggc cagcctgagc 961 tgcagaggat caagacagca cgtggacctc gcacagcctc tcccacaggt accatg (2) INFORMATION FOR SEQ ID NO:2617: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1141 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO: 2617 1 cctccgacag cctctccaca ggtaccatga aggtctccgc ggcacgcctc gctgtcatcc 61 tcattgctac tgccctctgc gctcctgcat ctgcctcccc atattcctcg gacaccacac 121 cctgctgctt tgcctacatt gcccgcccac tgccccgtgc ccacatcaag gagtatttct 181 acaccagtgg caagtgctcc aacccagcag tcgtctttgt cacccgaaag aaccgccaag 241 tgtgtgccaa cccagagaag aaatgggttc gggagtacat caactctttg gagatgagct 301 aggatggaga gtccttgaac ctgaacttac acaaatttgc ctgtttctgc ttgctcttgt 361 cctagcttgg gaggcttccc ctcactatcc taccccaccc gctccttgaa gggcccagat 421 tctgaccacg acgagcagca gttacaaaaa ccttccccag gctggacgtg gtggctcagc 481 cttgtaatcc cagcactttg ggaggccaag gtgggtggat cacttgaggt caggagttcg 541 agacagcctg gccaacatga tgaaacccca tgtgtactaa aaatacaaaa aattagccgg 601 gcgtggtagc gggcgcctgt agtcccagct actcgggagg ctgaggcagg agaatggcgt 661 gaacccggga gcggagcttg cagtgagccg agatcgcgcc actgcactcc agcctgggcg 721 acagagcgag actccgtctc aaaaaaaaaa aaaaaaaaaa aaaaaataca aaaattagcc 781 gcgtggtggc ccacgcctgt aatcccagct actcgggagg ctaaggcagg aaaattgttt 841 gaacccagga ggtggaggct gcagtgagct gagattgtgc cacttcactc cagcctgggt 901 gacaaagtga gactccgtca caacaacaac aacaaaaagc ttccccaact aaagcctaga 961 agagcttctg aggcgctgct ttgtcaaaag gaagtctcta ggttctgagc tctggctttg 1021 ccttggcttt gcaagggctc tgtgacaagg aaggaagtca gcatgcctct agaggcaagg 1081 aagggaggaa cactgcactc ttaagcttcc gccgtctcaa cccctcacag gagcttactg 1141 gcaaacatga aaaatcgggg (2) INFORMATION FOR SEQ ID NO:2618: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 2102 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO: 2618 1 gtcgaggatc cctaaagtcc tttgaagctt tcatattctg taacttttgt gccaagaagg 61 ccttacagtg agatgggatc ccagtattta ttgagtttcc tcattcataa aatggggata 121 ataatagtaa atgagttgac acgcgctaag acagtggaat agtggctggc acagataagc 181 cctcggtaaa tggtagccaa taatgataga gtatgctgta agatatcttt ctctccctct 241 gcttctcaac aagtctctaa tcaattattc cactttataa acaaggaaat agaactcaaa 301 gacattaagc acttttccaa aggtcgctta gcaagtaaat gggagagacc ctatgaccag 361 gatgaaagca agaaattccc acaagaggac tcattccaac tcatatcttg tgaaaaggtt 421 cccaatgccc agctcagatc aactgcctca atttacagtg tgagtgtgct cacctccttt 481 ggggactgta tatccagagg accctcctca ataaaacact ttataaataa catccttcca 541 tggatgaggg aaaggaggta agatctgtaa tgaataagca ggaactttga agactcagtg 601 actcagtgag taataaagac tcagtgactt ctgatcctgt cctaactgcc actccttgtt 661 gtcccaagaa agcggcttcc tgctctctga ggaggacccc ttccctggaa ggtaaaacta 721 aggatgtcag cagagaaatt tttccaccat tggtgcttgg tcaaagagga aactgatgag 781 ctcactctag atgagagagc agtgagggag agacagagac tcgaatttcc ggagctattt 841 cagttttctt ttccgttttg tgcaatttca cttatgatac cggccaatgc ttggttgcta 901 ttttggaaac tccccttagg ggatgcccct caactggccc tataaagggc cagcctgagc 961 tgcagaggat caagacagca cgtggacctc gcacagcctc tcccacaggt accatg 1 cctccgacag cctctccaca ggtaccatga aggtctccgc ggcacgcctc gctgtcatcc 61 tcattqctac tgccctctgc gctcctgcat ctgcctcccc atattcctcg gacaccacac WO 00/09525 PCT/US99/17712 EPI-109 786 121 cctgctgctt tgcctacatt gcccgcccac tgccccgtgc ccacatcaag gagtatttct 181 acaccagtgg caagtgctcc aacccagcag tcgtctttgt cacccgaaag aaccgccaag 241 tgtgtgccaa cccagagaag aaatgggttc gggagtacat caactctttg gagatgagct 301 aggatggaga gtccttgaac ctgaacttac acaaatttgc ctgtttctgc ttgctcttgt 361 cctagcttgg gaggcttccc ctcactatcc taccccaccc gctccttgaa gggcccagat 421 tctgaccacg acgagcagca gttacaaaaa ccttccccag gctggacgtg gtggctcagc 481 cttgtaatcc cagcactttg ggaggccaag gtgggtggat cacttgaggt caggagttcg 541 agacagcctg gccaacatga tgaaacccca tgtgtactaa aaatacaaaa aattagccgg 601 gcgtggtagc gggcgcctgt agtcccagct actcgggagg ctgaggcagg agaatggcgt 661 gaacccggga gcggagcttg cagtgagccg agatcgcgcc actgcactcc agcctgggcg 721 acagagcgag actccgtctc aaaaaaaaaa aaaaaaaaaa aaaaaataca aaaattagcc 781 gcgtggtggc ccacgcctgt aatcccagct actcgggagg ctaaggcagg aaaattgttt 841 gaacccagga ggtggaggct gcagtgagct gagattgtgc cacttcactc cagcctgggt 901 gacaaagtga gactccgtca caacaacaac aacaaaaagc ttccccaact aaagcctaga 961 agagcttctg aggcgctgct ttgtcaaaag gaagtctcta ggttctgagc tctggctttg 1021 ccttggcttt gcaagggctc tgtgacaagg aaggaagtca gcatgcctct agaggcaagg 1081 aagggaggaa cactgcactc ttaagcttcc gccgtctcaa cccctcacag gagcttactg 1141 gcaaacatga aaaatcgggg (2) INFORMATION FOR SEQ ID NO:2619: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 3961 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO: 2619 1 attaaacctc tcgccgagcc cctccgcaga ctctgcgccg gaaagtttca tttgctgtat 61 gccatcctcg agagctgtct aggttaacgt tcgcactctg tgtatataac ctcgacagtc 121 ttggcaccta acgtgctgtg cgtagctgct cctttggttg aatccccagg cccttgttgg 181 ggcacaaggt ggcaggatgt ctcagtggta cgaacttcag cagcttgact caaaattcct 241 ggagcaggtt caccagcttt atgatgacag ttttcccatg gaaatcagac agtacctggc 301 acagtggtta gaaaagcaag actgggagca cgctgccaat gatgtttcat ttgccaccat 361 ccgttttcat gacctcctgt cacagctgga tgatcaatat agtcgctttt ctttggagaa 421 taacttcttg ctacagcata acataaggaa aagcaagcgt aatcttcagg ataattttca 481 ggaagaccca atccagatgt ctatgatcat ttacagctgt ctgaaggaag aaaggaaaat 541 tctggaaaac gcccagagat ttaatcaggc tcagtcgggg aatattcaga gcacagtgat 601 gttagacaaa cagaaagagc ttgacagtaa agtcagaaat gtgaaggaca aggttatgtg 661 tatagagcat gaaatcaaga gcctggaaga tttacaagat gaatatgact tcaaatgcaa 721 aaccttgcag aacagagaac acgagaccaa tggtgtggca aagagtgatc agaaacaaga 781 acagctgtta ctcaagaaga tgtatttaat gcttgacaat aagagaaagg aagtagttca 841 caaaataata gagttgctga atgtcactga acttacccag aatgccctga ttaatgatga 901 actagtggag tggaagcgga gacagcagag cgcctgtatt ggggggccgc ccaatgcttg 961 cttggatcag ctgcagaact ggttcactat agttgcggag agtctgcagc aagttcggca 1021 gcagcttaaa aagttggagg aattggaaca gaaatacacc tacgaacatg accctatcac 1081 aaaaaacaaa caagtgttat gggaccgcac cttcagtctt ttccagcagc tcattcagag 1141 ctcgtttgtg gtggaaagac agccctgcat gccaacgcac cctcagaggc cgctggtctt 1201 gaagacaggg gtccagttca ctgtgaagtt gagactgttg gtgaaattgc aagagctgaa 1261 ttataatttg aaagtcaaag tcttatttga taaagatgtg aatgagagaa atacagtaaa 1321 aggatttagg aagttcaaca ttttgggcac gcacacaaaa gtgatgaaca tggaggagtc 1381 caccaatggc agtctggcgg ctgaatttcg gcacctgcaa ttgaaagaac agaaaaatqc 1441 tggcaccaga acgaatgagg gtcctctcat cgttactgaa gagcttcact cccttagttt 1501 tgaaacccaa ttgtgccagc ctggtttggt aattgacctc gagacgacct ctctgcccgt 1561 tgtggtgatc tccaacgtca gccagctccc gagcggttgg gcctccatcc tttggtacaa 1621 catgctggtg gcggaaccca ggaatctgtc cttcttcctg actccaccat gtgcacgatg 1681 ggctcagctt tcagaagtgc tgagttggca gttttcttct gtcaccaaaa gaggtctcaa 1741 tgtggaccag ctgaacatgt tgggagagaa gcttcttggt cctaacgcca gccccgatgg 1801 tctcattccg tggacgaggt tttgtaagga aaatataaat gataaaaatt ttcccttctg 1861 gctttggatt gaaagcatcc tagaactcat taaaaaacac ctgctccctc tctggaatga 1921 tgggtgcatc atgggcttca tcagcaagga gcgagagcgt gccctgttga aggaccagca 1981 gccggggacc ttcctgctgc ggttcagtga gagctcccgg gaaggggcca tcacattcac 2041 atgggtggag cggtcccaga acggaggcga acctgacttc catgcggttg aaccctacac 2101 gaagaaagaa ctttctgctg ttactttccc tgacatcatt cgcaattaca aagtcatggc 2161 tgctgagaat attcctgaga atcccctgaa gtatctgtat ccaaatattg acaaagacca 2221 tgcctttgga aagtattact ccaggccaaa ggaagcacca gagccaatgg aacttgatgg 2281 ccctaaagga actggatata tcaagactga gttgatttct gtgtctgaag ttcacccttc 2341 tagacttcag accacagaca acctgctccc catgtctcct gaggagtttg acgaggtgtc 2401 tcggatagtg ggctctgtag aattcgacag tatgatgaac acagtataga gcatgaatt 2461 ttttcatctt ctctggcgac agttttcctt ctcatctgtg attccctcct gctactctgt WO 00/09525 PCT/US99/17712 EPI-109 787 2521 tccttcacat cctgtgrztc tagggaaatg aaagaaaggc cagcaaattc gctgcaacct 2581 gttgatagca agtgaa-ttt tctctaactc agaaacatca gttactctga agggcatcat 2641 gcatcttact gaaggtaaaa ttgaaaggca ttctctgaag agtgggtttc acaagtgaaa 2701 aacatccaga tacacccaaa gtatcaggac gagaatgagg gtcctttggg aaaggagaag 2761 ttaagcaaca tctagcaaat gttatgcata aagtcagtgc ccaactgtta taggttgttg 2821 gataaatcag tggttattta gggaactgct tgacgtagga acggtaaatt tctgtgggag 2881 aattcttaca tgttttcttt gctttaagtg taactggcag ttttccattg gtttacctgt 2941 gaaatagttc aaagccaagt ttatatacaa ttatatcagt cctctttcaa aggtagccat 3001 catggatctg gtagggggaa aatgtgtatt ttattacatc tttcacattg gctatttaaa 3061 gacaaagaca aattctgttt cttgagaaga gaatattagc tttactgttt gttatggctt 3121 aatgacacta gctaatatca atagaaggat gtacatttcc aaattcacaa gttgtgtttg 3181 atatccaaag ctgaatacat tctgctttca tcttggtcac atacaattat ttttacagtt 3241 ctcccaaggg agttaggcta ttcacaacca ctcattcaaa agttgaaatt aaccatagat 3301 gtagataaac tcagaaattt aattcatgtt tcttaaatgg gctactttgt cctttttgtt 3361 attagggtgg tatttagtct attagccaca aaattgggaa aggagtagaa aaagcagtaa 3421 ctgacaactt gaataataca ccagagataa tatgagaatc agatcatttc aaaactcatt 3481 tcctatgtaa ctgcattaag aactgcatat gtttcgctga tatatgtgtt tttcacattt 3541 gcgaatggtt ccattctctc tcctgtactt tttccagaca cttttttgag tggatgatgt 3601 ttcgtgaagt atactgtatt tttacctttt tccttcctta tcactgacac aaaaagtaga 3661 ttaagagatg ggtttgacaa ggttcttccc ttttacatac tgctgtctat gtggctgtat 3721 cttgtttttc cactactgct accacaacta tattatcatg caaatgctgt attcttcttt 3781 ggtggagata aagatttctt gagttttgtt ttaaaattaa agctaaagta tctgtattgc 3841 attaaatata atatcgacac agtgctttcc gtggcactgc atacaatctg aggcctcctc 3901 tctcagtttt tatatagatg gcgagaacct aagtttcagt tgattttaca altgaaatga 3961 ctaaaaaaca aagaagacaa cattaaaaac aatattgttt cta (2) INFORMATION FOR SEQ ID NO:2620: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 2581 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2620 1 attaaacctc tcgccgagcc cctccgcaga ctctgcgccg gaaagtttca tttgctgtat 61 gccatcctcg agagctgtct aggttaacgt tcgcactctg tgtatataac ctcgacagtc 121 ttggcaccta acgtgctgtg cgtagctgct cctttggttg aatccccagg cccttgttgg 181 ggcacaaggt ggcaggatgt ctcagtggta cgaacttcag cagcttgact caaaattcct 241 ggagcaggtt caccagcttt atgatgacag ttttcccatg gaaatcagac agtacctggc 301 acagtggtta gaaaagcaag actgggagca cgctgccaat gatgtttcat ttgccaccat 361 ccgttttcat gacctcctgc cacagctgga tgatcaatat agtcgctttt ctttggagaa 421 taacttcttg ctacagcata acataaggaa aagcaagcgt aatcttcagg ataattttca 481 ggaagaccca atccagagt ctatgatcat ttacagctgt ctgaaggaag aaaggaaaat 541 tctggaaaac gcccagagat ttaatcaggc tcagtcgggg aatattcaga gcacagtgat 601 gttagacaaa cagaaagagc ttgacagtaa agtcagaaat gtgaaggaca aggttatgtg 661 tatagagcat gaaatcaaga gcctggaaga tttacaagat gaatatgact tcaaatgcaa 721 aaccttgcag aacagagaac acgagaccaa tggtgtggca aagagtgatc agaaacaaga 781 acagctgtta ctcaagaaga tgtatttaat gcttgacaat aagagaaagg aagtagttca 841 caaaataata gagttgctga atgtcactga acttacccag aatgccctga ttaatgatga 901 actagtggag tggaagcgga gacagcagag cgcctgtatt ggggggccgc ccaatgcttg 961 cttggatcag ctgcagaact ggttcactat agttgcggag agtctgcagc aagttcggca 1021 gcagcttaaa aagttggagg aattggaaca gaaatacacc tacgaacatg accctatcac 1081 aaaaaacaaa caagtgttat gggaccgcac cttcagtctt ttccagcagc tcattcagag 1141 ctcgtttgtg gtggaaagac agccctgcat gccaacgcac cctcagaggc cgctggtctt 1201 gaagacaggg gtccagttca ctgtgaagtt gagactgttg gtgaaattgc aagagctgaa 1261 ttataatttg aaagtcaaag tcttatttga taaagatgtg aatgagagaa atacagtaaa 1321 aggatttagg aagttcaaca ttttgggcac gcacacaaaa gtgatgaaca tggaggagtc 1381 caccaatggc agtctggcgg ctgaatttcg gcacctgcaa ttgaaagaac agaaaaatgc 1441 tggcaccaga acgaatgagg gtcctctcat cgttactgaa gagcttcact cccttagttt 1501 tgaaacccaa ttgtgccagc ctggtttggt aattgacctc gagacgacct ctctgcccgt 1561 tgtggtgatc tccaacgtca gccagctccc gagcggttgg gcctccatcc tttggtacaa 1621 catgctggtg gcggaaccca ggaatctgtc cttcttcctg actccaccat gtgcacgatg 1681 ggctcagctt tcagaagtgc tgagttggca gttttcttct gtcaccaaaa gaggtctcaa 1741 tgtggaccag ctgaacatgc tgggagagaa gcttcttggt cctaacgcca gccccgatgg 1801 tctcattccg tggacgaggt tttgtaagga aaatataaat gataaaaatt ttcccttctg 1861 gctttggatt gaaagcatcc tagaactcat taaaaaacac ctgctccctc tctggaatga 1921 tgggtgcatc atgggcttca tcagcaagga gcgagagcgt gccctattga aggaccagca 1981 gccggggacc ttcctgctgc ggttcagtga gagctcccgg gaaggggcca tcacattcac 2041 atgggtggag cggtcccaga acggaggcga acctgacttc catgcggttg aaccctacac 2101 gaagaaagaa ctttctgctg ttactttccc tgacatcatt cgcaattaca aagtcatggc WO 00/09525 PCTIUS99/17712 EPI-109 788 2161 tgctgagaat attcctgaga atcccctgaa gtatctgtat ccaaatattg acaaagacca 2221 tgcctttgga aagtattact ccaggccaaa ggaagcacca gagccaatgg aacttgatgg 2281 ccctaaagga actggatata tcaagactga gttgatttct gtgtctgaag tgtaagtgaa 2341 cacagaagag tgacatgttt acaaacctca agccagcctt gctcctggct ggggcctgtt 2401 gaagatgctt gtattttact tttccattgt aattgctatc gccatcacag ctgaacttgt 2461 tgagatcccc gtgttactgc ctatcagcat tttactactt taaaaaaaaa aaaaaaagcc 2521 aaaaaccaaa tttgtattta aggtatataa attttcccaa aactgatacc ctttgaaaaa 2581 gtataaataa aatgagcaaa agttgaa (2) INFORMATION FOR SEQ ID NO:2621: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 61 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2621 1 ttactaagat gattattgtt ttatagcaat tgaaagaaca gaaaaatgct ggcaccagaa 61 cgaatgaggt gagagtggtt tatgttgtga atgggcc (2) INFORMATION FOR SEQ ID NO:2622: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 181 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2622 1 acgacctctc tgcccgttgt ggtgatctcc aacgtcagcc agctcccgag cggttgggcc 61 tccatccttt ggtacaacat gctggtggtg gcggaaccca gggtatggaa aacacatttg 121 ctttggtccc agggtttaag cagagacccc acgctctcgc tgctgcatct cgctgctgca 181 tctctgaaat agccccaat (2) INFORMATION FOR SEQ ID NO:2623: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 61 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2623 1 ggtctcaatg tggaccagct gaacatgttg ggagagaagc ttcttggtat atgcatatta 61 acttgttatg tttataaaaa ttgaaattca taaaaatatc (2) INFORMATION FOR SEQ ID NO:2624: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 121 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2624 1 ctgatcagta gaaaacatgt ttacatcttt gtttgtagtg tatagagcat gaaatcaaga 61 gcctggaaga tttacaagat gaatatgact tcaaatgcaa aaccttgcag aacagaggta 121 agggttcaca actgaagtgg tgcccgttgg (2) INFORMATION FOR SEQ ID NO:2625: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 6966 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2625 1 attaaacctc tcgccgagcc cctccgcaga ctctgcgccg gaaagtttca tttgctgtat 61 gccatcctcg agagctgtct aggttaacgt tcgcactctg tgtatataac ctcgacagtc 121 ttggcaccta acgtgctgtg cgtagctgct cctttggttg aatccccagg cccttgttgg 181 ggcacaaggt ggcaggatgt ctcagtggta cgaacttcag cagcttgact caaaattcct 241 ggagcaggtt caccagcttt atgatgacag ttttcccatg gaaatcagac agtacctggc 301 acagtggtta gaaaagcaag actgggagca cgctgccaat gatgtttcat ttgccaccat 361 ccgttttcat gacctcctgt cacagctgga tgatcaatat agtcgctttt ctttggagaa 421 taacttcttg ctacagcata acataaggaa aagcaagcgt aatcttcagg ataattttca 481 ggaagaccca atccagatgt ctatgatcat ttacagctgt ctgaaggaag aaaggaaaat 541 tctggaaaac gcccagagat ttaatcaggc tcagtcgggg aatattcaga gcacagtgat 601 gttagacaaa cagaaagagc ttgacagtaa agtcagaaat gtgaaggaca aggttatgtg 661 tatagagcat gaaatcaaga gcctggaaga tttacaagat gaatatgact tcaaatgcaa WO 00/09525 PCT/US99/17712 EPI-109 789 721 aaccttgcag aacagagaac acgagaccaa tggtgtggca aagagtgatc agaaacaaga 781 acagctgtta ctcaagaaga tgtatttaat gcttgacaat aagagaaagg aagtagttca 841 caaaataata gagttgctga atgtcactqa acttacccag aatgccctga ttaatgatga 901 actagtggag tggaagcgga gacagcagag cgcctgtatt ggggggccgc ccaatgcttg 961 cttggatcag ctgcagaact ggttcactat agttgcggag agtctgcagc aagttcggca 1021 gcagcttaaa aagttggagg aattggaaca gaaatacacc tacgaacatg accctatcac 1081 aaaaaacaaa caagtgttat gggaccgcac cttcagtctt ttccagcagc tcattcagag 1141 ctcgtttgtg gtggaaagac agccctgcat gccaacgcac cctcagaggc cgctggtctt 1201 gaagacaggg gtccagttca ctgtgaagtt gagactgttg gtgaaattgc aagagctgaa 1261 ttataatttg aaagtcaaag tcttatttga taaagatgtg aatgagagaa atacagtaaa 1321 aggatttagg aagttcaaca ttttgggcac gcacacaaaa gtgatgaaca tggaggagtc 1381 caccaatggc agtctggcgg ctgaatttcg gcacctgcaa ttgaaagaac agaaaaatgc 1441 tggcaccaga acgaatgagg gtcctctcat cgttactgaa gagcttcact cccttagttt 1501 tgaaacccaa ttgtgccagc ctggtttggt aattgacctc gagacgacct ctctgcccgt 1561 tgtggtgatc tccaacgtca gccagctccc gagcggttgg gcctccatcc tttggtacaa 1621 catgctggtg gcggaaccca ggaatctgtc cttcttcctg actccaccat gtgcacgatg 1681 ggctcagctt tcagaagtgc tgagttggca gttttcttct gtcaccaaaa gaggtctcaa 1741 tgtggaccag ctgaacatg t tgggagagaa gcttcttggt cctaacgcca gccccgatgg 1801 tctcattccg tggacgaggt tttgtaagga aaatataaat gataaaaatt ttcccttctg 1861 gctttgqatt gaaagcatcc tagaactcat taaaaaacac ctgctccctc tctggaatga 1921 tgggtgcatc atgggcttca tcagcaagga gcgagagcgt gccctgttga aggaccagca 1981 gccggggacc ttcctgctgc ggttcagtga gagctcccgg gaaggggcca tcacattcac 2041 atgggtggag cggtcccaga acggaggcga acctgacttc catgcggttg aaccctacac 2101 gaagaaagaa ctttctgctg ttactttccc tgacatcatt cgcaattaca aagtcatggc 2161 tgctgagaat attcctgaga atcccctgaa gtatctgtat ccaaatattg acaaagacca 2221 tgcctttgga aagtattact ccaggccaaa ggaagcacca gagccaatgg aacttgatgg 2281 ccctaaagga actggatata tcaagactga gttgatttct gtgtctgaag ttcacccttc 2341 tagacttcag accacagaca acctgctccc catgtctcct gaggagtttg acgaggtgtc 2401 tcggatagtg ggctctgtag aattcgacag tatgatgaac acagtataga gcatgaattt 2461 ttttcatctt ctctggcgac agttttcctt ctcatctgtg attccctcct gctactctgt 2521 tccttcacat cctgtgtttc tagggaaatg aaagaaaggc cagcaaattc gctgcaacct 2581 gttgatagca agtgaatttt tctctaactc agaaacatca gttactctga agggcatcat 2641 gcatcttact gaaggtaaaa ttgaaaggca ttctctgaag agtgggtttc acaagtgaaa 2701 aacatccaga tacacccaaa gtatcaggac gagaatgagg gtcctttggg aaaggagaag 2761 ttaagcaaca tctagcaaat gttatgcata aagtcagtgc ccaactgtta taggttgttg 2821 gataaatcag tggttattta gggaactgct tgacgtagga acggtaaatt tctgtgggag 2881 aattcttaca tgttttcttt gctttaagtg taactggcag ttttccattg gtttacctgt 2941 gaaatagttc aaagccaagt ttatatacaa ttatatcagt cctctttcaa aggtagccat 3001 catggatctg gtagggggaa aatgtgtatt ttattacatc tttcacattg gctatttaaa 3061 gacaaagaca aattctgttt cttgagaaga gaatattagc tttactgttt gttatggctt 3121 aatgacacta gctaatatca atagaaggat gtacatttcc aaattcacaa gttgtgtttg 3181 atatccaaag ctgaatacat tctgctttca tcttggtcac atacaattat ttttacagtt 3241 ctcccaaggg agttaggcta ttcacaacca ctcattcaaa agttgaaatt aaccatagat 3301 gtagataaac tcagaaattt aattcatgtt tcttaaatgg gctacittgt cctttttgtt 3361 attagggtgg tatttagtct attagccaca aaattgggaa aggagtagaa aaagcagtaa 3421 ctgacaactt gaataataca ccagagataa tatgagaatc agatcatttc aaaactcatt 3481 tcctatgtaa ctgcattgag aactgcatat gtttcgctga tatatgtgtt tttcacattt 3541 gcgaatggtt ccattctctc tcctgtactt tttccagaca cttttttgag tggatgatgt 3601 ttcgtgaagt atactgtatt tttacctttt tccttcctta tcactgacac aaaaagtaga 3661 ttaagagatg ggtttgacaa ggttcttccc ttttacatac tgctgtctat gtggctgtat 3721 cttgtttttc cactactgct accacaacta tattatcatg caaatgctgt attcttcttt 3781 ggtggagata aagatttctt gagttttgtt ttaaaattaa agctaaagta tctgtattgc 3841 attaaatata atatcgacac agtgctttcc gtggcactgc atacaatctg aggcctcctc 3901 tctcagtttt tatatagatg gcgagaacct aagtttcagt tgattttaca attgaaatga 3961 ctaaaaaaca aagaagacaa cattaaaaac aatattgttt cta 1 attaaacctc tcgccgagcc cctccgcaga ctctgcgccg gaaagtttca tttgctgtat 61 gccatcctcg agagctgtct aggttaacgt tcgcactctg tgtatataac ctcgacagtc 121 ttggcaccta acgtgctgtg cgtagctgct cctttggttg aatccccagg cccttgttgg 181 ggcacaaggt ggcaggatgt ctcagtggta cgaacttcag cagcttgact caaaattcct 241 ggagcaggtt caccagcttt atgatgacag ttttcccatg gaaatcagac agtacctggc 301 acagtggtta gaaaagcaag actgggagca cgctgccaat gatgtttcat ttgccaccat 361 ccgttttcat gacctcctgt cacagctgga tgatcaatat agtcgctttt ctttggagaa 421 taacttcttg ctacagcata acataaggaa aagcaagcgt aatcttcagg ataattttca 481 ggaagaccca atccagatgt ctatgatcat ttacagctgt ctgaaggaag aaaggaaaat 541 tctggaaaac gcccagagat ttaatcaggc tcagtcgggg aatattcaga gcacagtgat 601 gttagacaaa cagaaagagc ttgacagtaa agtcagaaat gtgaaggaca aggttatgtg 661 tatagagcat gaaatcaaga gcctggaaga tttacaagat gaatatgact tcaaatgcaa 721 aaccttgcag aacagagaac acgagaccaa tggtgtggca aagagtgatc agaaacaaga WO 00/09525 PCT/US99/17712 EPI-109 790 781 acagctgtta ctcaagaaga tgtatttaat gcttgacaat aagagaaagg aagtagttca 841 caaaataata gagttgctga atgtcactga acttacccag aatgccctga ttaatgatga 901 actagtggag tggaagcgga gacagcagag cgcctgtatt ggggggccgc ccaatgcttg 961 cttggatcag ctgcagaact ggttcactat agttgcggag agtctgcagc aagttcggca 1021 gcagcttaaa aagttggagg aattggaaca gaaatacacc tacgaacatg accctatcac 1081 aaaaaacaaa caagtgttat gggaccgcac cttcagtctt ttccagcagc tcattcagag 1141 ctcgtttgtg gtggaaagac agccctgcat gccaacgcac cctcagaggc cgctggtctt 1201 gaagacaggg gtccagttca ctgtgaagtt gagactgttg gtgaaattgc aagagctgaa 1261 ttataatttg aaagtcaaag tcttatttga taaagatgtg aatgagagaa atacagtaaa 1321 aggatttagg aagttcaaca ttttgggcac gcacacaaaa gtgatgaaca tggaggagtc 1381 caccaatggc agtctggcgg ctgaatttcg gcacctgcaa ttgaaagaac agaaaaatgc 1441 tggcaccaga acgaatgagg gtcctctcat cgttactgaa gagcttcact cccttagttt 1501 tgaaacccaa ttgtgccagc ctggtttggt aattgacctc gagacgacct ctctgcccgt 1561 tgtggtgatc tccaacgtca gccagctccc gagcggttgg gcctccatcc tttggtacaa 1621 catgctggtg gcggaaccca ggaatctgtc cttcttcctg actccaccat gtgcacgatg 1681 ggctcagctt tcagaagtgc tgagttggca gttttcttct gtcaccaaaa gaggtctcaa 1741 tgtggaccag ctgaacatgt tgggagagaa gcttcttggt cctaacgcca gccccgatgg 1801 tctcattccg tggacgaggt tttgtaagga aaatataaat gataaaaatt ttcccttctg 1861 gctttggatt gaaagcatcc tagaactcat taaaaaacac ctgctccctc tctggaatga. 1921 tgggtgcatc atgggcttca tcagcaagga gcgagagcgt gccctgttga aggaccagca 1981 gccggggacc ttcctgctgc ggttcagtga gagctcccgg gaaggggcca tcacattcac 2041 atgggtggag cggtcccaga acggaggcga acctgacttc catgcggttg aaccctacac 2101 gaagaaagaa ctttctgctg ttactttccc tgacatcatt cgcaattaca aagtcatggc 2161 tgctgagaat attcctgaga atcccctgaa gtatctgtat ccaaatattg acaaagacca 2221 tgcctttgga aagtattact ccaggccaaa ggaagcacca gagccaatgg aacttgatgg 2281 ccctaaagga actggatata tcaagactga gttgatttct gtgtctgaag tgtaagtgaa 2341 cacagaagag tgacatgttt acaaacctca agccagcctt gctcctggct ggggcctgtt 2401 gaagatgctt gtattttact tttccattgt aattgctatc gccatcacag ctgaacttgt 2461 tgagatcccc gtgttactgc ctatcagcat tttactactt taaaaaaaaa aaaaaaagcc 2521 aaaaaccaaa tttgtattta aggtatataa attttcccaa aactgatacc ctttgaaaaa 2581 gtataaataa aatgagcaaa agttgaa 1 ttactaagat gattattgtt ttatagcaat tgaaagaaca gaaaaatgct ggcaccagaa 61 cgaatgaggt gagagtggtt tatgttgtga atgggcc 1 acgacctctc tgcccgttgt ggtgatctcc aacgtcagcc agctcccgag cggttgggcc 61 tccatccttt ggtacaacat gctggtggtg gcggaaccca gggtatggaa aacacatttg 121 ctttggtccc agggtttaag cagagacccc acgctctcqc tgctgcatct cgctgctgca 181 tctctgaaat agccccaat 1 ggtctcaatg tggaccagct gaacatgttg ggagagaagc ttcttggtat atgcatatta 61 acttgttatg tttataaaaa ttgaaattca taaaaatatc 1 ctgatcagta gaaaacatgt ttacatcttt gtttgtagtg tatagagcat gaaatcaaga 61 gcctggaaga tttacaagat gaatatgact tcaaatgcaa aaccttgcag aacagaggta 121 agggttcaca actgaagtgg tgcccgttgg (2) INFORMATION FOR SEQ ID NO:2626: (1) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18601 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2626 1 tcaagatcag cctgggca 'ac atggcgaaac cccgtctcta caataaatac aaaaaaatta 61 tcctggcgga gttatgcacg ttgtagtccc aactacctgg gaggctgagg cgggagaatc 121 acctgagcct gggaggtcga ggctgcagcg agccgagatc ggccgctgca ttccagcctg 181 ggtgacagag cgagaccatg tctcaaaaaa taaaaattaa aaaaaaattg ttttcattac 241 ctcagccctc ctcttcctat cccaaggcgt cgaaattccg gtcccacccc ttcccatgga 301 gcccttggcg tctccaggct cctcaagcta gtttcggttc cgggctcacg cgcgggttct 361 cgaaaatcag ctgtttcagt cttgggctag tccactaatt ggactcctcc cctcgtagaa 421 agtgcctact tgaacttctc caccaatcgc tgaagctgca ggtgtggttt cggctcagct 481. tgtcccgccc tggcggaggg gcggagttgc ggcggcgcca gtgagctcgc agtctgggaa 541 gggcttgact gaatggcagc cagtgtcggg gtggcggctg ggaatggggg ccgctccgga 601 cttccgctgc caactacaag ggggcgggtc cgaggggggt tagccgaagt tgtaggcggg 661 gcgcgaggtt ctagtacccg agctcatact agggacggga agtcgcgacc agagccattg 721 gagggcgcgg ggactgcaac cctaatcagg tacgggccct gagagggtgt gctggggtag 781 gggtgggggt gagagtgaga gttcctccga gggaagggcg actggcccag gggttacccc 841 ctggagaggg tagcttcctt ccccagattg aaataggagc tgtcgcctgc tcggtcctcg 901 atcttcttct gtccagccta tctccctaac cctaatgccc ctctcccaaa actgccctgc 961 agcttccgag acccggaacc tggcattgtt atgttggttc ggtatczgac gtttttccct 1021 ctgctctgca ttatttttta tcttcaccaa aaaacgatgt tcaaagatag ataaatctaa WO 00/09525 PCT/US99/17712 EPI-109 791 1081 aaacaaagat agataaatct attacccttg tttcgtaaaa agtataagct actgaaagat 1141 gaaacgattg cctaaggtca cacacaaaat tcagttcatt tcagaaaagc ttcttgagtg 1201 caaaatatgt gcctaagaat gagagataat gagaaaaaat tgtttcagcc ccttaacctc 1261 agtgtttgca atccatttgg ggagaccagg ttttttgttt ttgttttcat atttgaatct 1321 ttgctgactt gctcctttaa tatcagacac ttaaatcctc agatgggact catcatattt 1381 tttttgagat ggaatcttca ctatgttgct caagcttggt ctgcaactcc tggctcaagc 1441 catcctctcg tcttgttggg cctctcgtct tgtgggcctg cacaaagtgc tgggattaca 1501 ggcatgagcc attcatgccc tgggcgcacc ttggattgcg atgtgtgtgt gttgtgaagc 1561 tttttttttt ggtatcataa aagcaataca gatacatagt tttaaaaatc aagcagctac 1621 taaaagagtt aaaatgaaaa tagcccctcc caatccctcc cttgttcctg ctggaggtag 1681 aaaggcagct gatgttattc atgttagtag aagactctcc caccccaagc atttctcttt 1741 attttgtaat aaaatcatgt gaccttttta gaccacaaat atgcatgaat tctgttctgt 1801 taggctcagg ctgcaacaag ataagtttca gtttcctaaa tagacaccag ctggcagtga 1861 gcagggaaca gtggggagaa agatgcatgg gacagcctgc ttggtgacag gcaaaaaccg 1921 gtttgttgtt cttttagaga cagagtcttg ctttgtcacc caggctggag tgtagtgatg 1981 tgatctctgc ttactgcaac cctgcctctg ggtacaagcc attctcctgc ctcagcctct 2041 tgagtagctg ggattacagg caacaatttt aagtgaagtg aagtttcagg atctcgagca 2101 aagttgtata acctataatc atattcaaga ttcacaggtc ataaacgtgt catattcttg 2161 ggattgagcg acccattgca cagcatttag atgtgcttct agaatggagc tcctccttcc 2221 tatatggagg gcagtttata tggtgtactt acctgaccac caaaaagatt tggctctaaa 2281 aaagcttcag gtggccgggc atggtggttc acccctgtaa tccagcactt tgggaggcag 2341 gtgggcagat cacctgaggt cagaagttca gacagctgga catatggtga aacctcatct 2401 ctactaaaaa tacaaaaatt agactgggca tggtagtggg cgcctgtaat cccagctagt 2461 cgggaggctg aggcaggaga atcccttcaa ctcggacggc agagtttgca gtgaggccga 2521 gatcgtgtca ctgcagtcca gcctgggtga cagagcaaga ctccatctca aaaaaagtaa 2581 aaaaaaaaaa aagaaaaaaa aaagcttcag agccagcagg gatcatgctg taataaatac 2641 ttaacatcaa cactgatctt taaatgcttt agcacaatca aatataaata acaaacacac 2701 acataaatgc aaaataaatg aattagggag atagatgaaa taagattgtg gaaatagtaa 2761 tgtttgttaa agctggatgg tgatccttgt actattcact ctactctagt gtgtatttga 2821 aaattaccat taggctggtt atggtggctc atgcctgtta atcccggcat tttggaaggc 2881 tgaggcaggc ggattacttg agctcaggag tttagagtct gcctgggcaa catggcaaaa 2941 tcccatctct acaaaaaatt agctggcatg atggcacact cctgtagtcc cagctccttg 3001 aggggctgag gcagagaatg gcttgaacct gagaggctaa agctgcagtg agccaagatc 3061 atgccactgc actccagcct gggtgaccaa gtgagaccct gtctcaaaaa aaaaaaaaaa 3121 aaaaagaaaa gaaaattccc attaaagcac aaaggcccac ttattgaagc tattaaaata 3181 caggttgggg ccggctgggc atcgcgtcac gcctgtaatc ccagcacttt ggaaggccga 3241 ggtaggcgag tcacgagttc aggagatoga gaccatcctg gctaacacgg tgaaacccca 3301 tctctactaa aaatacaaaa aaaaaaatca gccgggcatg gtggcgggag cctatagtcc 3361 cagctactcg ggaggctgag gcaggagaat ggcatgagcc cgggaggcgg agcttgcagt 3421 gagccaaaat cacaccactg cactccagcc tgggcaacag atcgagactc catctgaaga 3481 aaaaaaaaat acaggttggg accacagtgg ctcatgcctg taatcctagt actttgggag 3541 tccgaagtag gtggatcacc tgaggtcagg actttgagac cagcctggcc aacatggcaa 3601 aaccccatct ctactaaaaa atatacaaaa attagctggg cgtggtggtg ggtgcctgta 3661 atcccagcta ctcaggaggc tgaggcagaa gaatcacaac aaccaggggg atggtggttg 3721 caatgagcca agatcatctc cacttcactc cggcccaggc aaaagagtga gagtcatctt 3781 aaaaaaaaaa aaaaaaaaaa aaaaaaaata cagattaggc attcctaatc tgaaaaattt 3841 ggctccaaaa tgctccagtc gagcatttcc tttgagtgtc atgtgggtgc tcaaaaagtt 3901 agatttttgg accattttca gatttcagag ttttggatta gggatgctcg actggtaagt 3961 aatcgagata ttccaaaaat ctggacaaat ctgaaatcca aaatgcttgg aatagcagat 4021 actcaactgg tagcactccc tggaagaata tgcaccaaac tgatagcagt ggttaccttc 4081 tggtgaggag gggaaagaac caagattagc agtaggatca acatatattt taatgttttc 4141 tgtattttta ttacttgtat aatttaaaca ttttaaatta gtaataatga acaatcatga 4201 aactatggat gatttagtcc agcaaaatat ccaattggga accctcatcc ttctgcagag 4261 cccaaatggc gcagtgggaa atgctgcaga atcttgacag cccctttcag gatcagctgc 4321 accagcttta ctcgcacagc ctcctgcctg tggacattcg acagtacttg gctgtctgga 4381 ttgaagacca gaactggtga ggccttcagg aagttggggg aatgaaaaag gtggccttcc 4441 acttctgggc ccccgggatc ctggaatcat taatggcagg aaggggttgg aaagcctcag 4501 gactacagta acactgcaga gacactaata cttcttattc ctggtcccag gcaggaagct 4561 gcacttggga gtgatgattc caaggctacc atgctattct tccacttctt ggatcagctg 4621 aactatgagt gtggccgttg cagccaggac ccagagtcct tgttgctgca gcacaatttg 4681 cggaaattct gccgggacat tcaggtactt ggaacggttg ggagtgatgg ggtagcactg 4741 ggagcagagc atagaggagt aaggtttgga gaatagaata gtacctggag gtggcaaggg 4801 agacgggaac aaatgtgggg aaaggaggac agagtctgga cttggggaat cactagcaga 4861 gagaagggtt gcatatacgt gacactgttg ggaggatgct atggtgaaaa gacaaagggc 4921 taagaacccc gaaggaggag gaaatactgt ggacattggt ggggagggtc tagggcaata 4981 ggtcattgag agtggttgaa ttggatcaat ccttctgtt tacctttctg ttagcccttt 5041 tcccaggatc ctacccagtt ggctgagatg atctttaacc tccttctgga agaaaaaaga 5101 attttgatcc aggctcagag ggcccaattg gtgaggacaa ttcagtggta atgttggaaa WO 00/09525 PCT/US99/17712 EPI-109 792 5161 ctcctgaagt agagaggaac catggaaagg actcagggag ttgtctcaga acaggatccc 5221 cccgacatcc tgtggtataa tttcaggcct gaacttaagg catgaaaggc cagagttaaa 5281 acgtgctcag agcctctttt ttcaggaaca aggagagcca gttctcaaaa cacctgtgga 5341 gagccagcaa catgagattg aatcccggat cctggattta agggctatga tggaggttag 5401 tagatgtggt aggagttagg gttgacagtg ttcagcctaa cacctccctg agaagcagcc 5461 tcatcggggt cctctcccct ctgcagaagc tggtaaaatc catcagccaa ctgaaagacc 5521 agcaggatgt cttctgcttc cgatataaga tccaggccaa aggtaggaag cacattgagg 5581 ggctggagaa agataagtgc ctgctgagaa gccggagctg gaagtgaaca ggagaaagct 5641 ccgatgagca qtagtcactg tcagacacac cccactgact acagtcctgc tgccgtgcaa 5701 agctggaatc gtgctttgtg gaggctgagc tggaggtgac agctgagaga cagtaaattg 5761 ttgaggaaat gcatggaaaa ctaacagtgt tttatttgag ggggtgtctg gtccaagatg 5821 accacttcag aatttgcctg gagggtccca caggtgcctg tgctttactt ggtttccctt 5881 tcttcctccg ccacaaaatt cctccttcct gactctgact gagaccccag tcaggaagga 5941 gaggaaagaa cccctggact gactcctgtt cccaccatcc agggaagaca ccctctctgg 6001 acccccatca gaccaaagag cagaagattc tgcaggaaac tctcaatgaa ctggacaaaa 6061 ggagaaaggt gggaggcagc agaacagaac atgtgggcaa caaggacctg aaaaaatgag 6121 ggatgttggg aaccctggta atctagcgct ggcttctttc tttcttcatc cccagttggg 6181 tggtggaggg tgaaagggag agatgctcaa cactcacatt atctctttcc caggaggtgc 6241 tggatgcctc caaagcactg ctaggccgat taactaccct aatcgagcta ctgctgccaa 6301 agttggagga gtggaaggcc cagcagcaaa aagcctgcat cagagctccc attgaccacg 6361 ggttggaaca gctggagaca tggtgagagg taccacccca accctcgtcc tcgccatgcg 6421 ctgtgatttg taagttgcag tgccctgcat atagcaagag atactgttct ctatttgtct 6481 ctgctcccca gaatagagcc ctgctccctg cctgactgca gctctattct gcctcctcag 6541 cctcaccacg cagggaagcc cagaagtccc agtctccttc agggaaagga atgaattaac 6601 ccacaatctg gttttgcttc ttttttttaa tcacccagaa atatatatat atgtattttt 6661 tttttactgc aacgaataca atgacaagaa aggaagggaa ggaaggaagg aagagaaaat 6721 tacctattac ctagcttatt aaacaaaaat ggaatcatat tgtccatact attttgaaat 6781 ccatggggtt ttttttaagc ttaacagtat tttatatata tatatatata tatatatata 6841 tatatatata tatatatata tatatttttt tttttttttt tttttttttt ttttgagacg 6901 gagtctctct ctgttccctg qctggcggag cggagtcggc acgatctcag ctcactgcaa 6961 cttccaactc ccacggttca agccaattct cctgtctcag cctcccgagc ctgggattac 7021 caggcacaca ccagcctggc tagttttttt gattttttag tagagacgat gtttctccat 7081 gttggccagg ctggtctcaa actcctgact tcaggtgatc cacccaactt gggctcccaa 7141 agtgctggga ttacaggcgt gacgaccatg cccggccaac agtatattat atttatccat 7201 gttatttctt atgtccacac aacagtcccc tatatggtgg taacataatt taattaatga 7261 actcctattt tcagctattt aggttatttt caatttcttg ttaccttttg ccaggaaacg 7321 tatattttat ggtaattata ttgtgttgta gaaaaatcac tagtctagtc caacttgctt 7381 gaaaaatagc tactttttaa ctattttctc atttaaaaat ttattataat ttagtctttt 7441 agaaatatac caggccaggc atggcgtctc atgcctgtta tcctagtact ttggaaggct 7501 gaggacggag gatcacttca gtcttggggt ttgagaccag cccgggaaac ataacaagac 7561 cccatctcta caaaaaaaaa aaattgtttt taattaggca tgtccgacac agtggctcac 7621 acatgtggcc agcactgtgg gaaggccaag gtgggtggat cacttgaggg tcaggagttc 7681 aagaccagcc tggccaatgt ggtgaaaccc catctctact aaaaatacaa aaatttgcca 7741 ggtgtggtgg cgcatgcctg tattcccagc tactcaggag gctaaggcag gaaatcactt 7801 gaactcggag gcagaggttg cagtgagctg tgacaatgcc actgtactcc agcctgggtg 7861 acagagcgag ctccgtctca aaaaaaaaaa aaaaagatta ggcatggtgg cacacgcctg 7921 tagaccctag ctactcagga ggctgaggtg ggaggattgc ttgagcccag gtgttggagg 7981 ctgcagtgag ccatgattat accactgtag tccagcctgg acaacagaac gagaccctgt 8041 ctctaaaagt atatatgtac acataccata atacccagct actgaggagg ctgaggcaga 8101 aagagtgctt gagtccagga gtttgatgtc agcctgagca atatagcaag accctcacct 8161 cttaaaaaaa tttaaagtag attaaaaaaa taccacaatt gctcaggtag attaaaaaaa 8221 taccacaatt gctcaggtag attattgaaa aacaggcata tagtacttat ggtacaggac 8281 cagcatgcat gcatgcatgc attgattgat tgattgattg attgattgag acagggtctc 8341 tctctgtctc ccaggctgga gtgcctggcc ttaagtgatc tgcccacctt tgcttcccaa 8401 agtgctgaga ttacaggtqt gagccaccat gtcagctggc gaggcttctt aaaagatagt 8461 tccaagtgtt acagctcttt taggatttgt ctagcaggct ttcaggtttt tgccagaaac 8521 cacccccacc cccaccaaaa aaaaaaaaaa aaaaaagata tgtacaagtt cccagatagt 8581 gttcccaact gaatctattt ctcatgtgta gtgtatggtt gttttcctgt caccacattg 8641 ctgattatta ttatttttaa ttatagagac agtaaagtac agtagttaaa aatgtgagtt 8701 ggggctgggt gcagtggctc acacctgtaa toccagcact ttgggaggcc aaggtgggcg 8761 gatcacctga ggtcaggagt tcaagaccag cttggccaac atggcaaaac cccgtctcga 8821 ctaaaaatat atatatataa gttagccggg cgtggtggca acattacccg taatcccagc 8881 tactcgggag gccaacaggc aggagaatct cttgaatcca ggaggtggag gttgcagtga 8941 gccagatcac accattgcac tccagcctgg atgacaagag agtgagactg tctaaaaaaa 9001 aaaaacaaag tgtgagttgt acaatgagac tgcctgggat cacatacaag cttcatccct 9061 tactagttgt atgacccta aagcaagtca ctaacctttc tgtgcccrcc agttttatca 9121 tctgtaatgt ggggaaaata atagtacctg cctcagaggg ttgttttag gattaaatgc 9181 attaatatgt ggaaagggct taatataagt tgtacatagc atatgaaaac tgttatgtta WO 00/09525 PCT/US99/17712 EPI-109 793 9241 aatctattag cagtttzata tgtgaaaata gctttgattt tcatttcttg gattatgaat 9301 catgttgaat aatccttzat atgcttcctg gattcttttt ttttcttccc cccagtcagt 9361 ttctgactct tctcataztt atagagagat cttggaacct ggatggggga atccaggaaa 9421 ctcatggatt ccttcttcct gaattttatc acccaggttc acagctggag caaagctgtt 9481 gtttcacctg aggcagctgc tgaaggagct gaagggactg agttgcctgg ttagctatca 9541 ggatgaccct ctgaccaaag gggtggacct acgcaacgcc caggtcacag agttgctaca 9601 gcgtctgctc cacaggtcta gaggccaggc aggaaccctg ggggaaagaa ggaacaaggg 9661 aagccattct tacacatact gagctatata ttctctccac acctctctct cctcgagcct 9721 ttgtggtaga aacccagccc tgcatgcccc aaactcccca tcgacccctc atcctcaaga 9781 ctggcagcaa gttcaccgtc cgaacaaggt tggcattcca gaactcattc ccacttcctt 9841 tttccaaccc tgccactgtg tattttctgg ctttacagct actgcccact cttggctttt 9901 tcagtctttc ctgaatctcc ctacctcgtt gatacccat cgtcctcttt ttcaaacacc 9961 tagcctatac aaaagccgac tccgaccaca tttccctata ccccttgact tccccaggct 10021 gctggtgaga ctccaggaag gcaatgagtc actgactgtg gaagtctcca ttgacaggta 10081 aattggagca ggtgaagggt ggccaggaca cgggctgctg gggtggagga gatactcact 10141 cttcacaaca gggccctagg gctatatcct tcctccttcc aatcctacct cacagaaatt 10201 ataattcatt tcttttgttg aacacttact ttgtgacatg cagcatgtca gctactcatt 10261 taattgtcac accaacccca tgaataaact attaccagtg cactgtacaa acaaagatac 10321 aggcttagag agactgatta catctcttct caaggccaca tagctagtga gctcaagtcg 10381 ggtttgaacc gaggtctgtc tgatcccaaa gacgaaactc ctaacttcca tactcttttg 10441 cccaatgatt ttttttaaat ttatttcttt tcaggaatcc tcctcaatta caagggtagg 10501 tgcttgacaa ggacactgca aacatctgta cagtgtatga cctgcagaac cgggggattt 10561 gggaaatgga caaagggaga tggcgagatc tgaaatggaa gtggaacttc agtttttttt 10621 ttttctgctg agtttttaca ataattccat tccttgtctc catgtatctt cctcctggaa 10681 cagcttccgg aagttcaaca ttctgacttc aaaccagaaa actttgaccc ccgagaaggg 10741 gcagagtcag ggtttgattt gggactttgg ttacctggta agaatagttt gtgacctatg 10801 cttttattac tatttttatt ttttcgagac ggagtctcac tctgtccccc aggctggagt 10861 gcagtggtgc catcttggct cacaggaacc tccgccctcc ccggttcaag caattcttct 10921 gtctcagcct cctgagtacg tagagctata ggcagcacac caccatgccc ggctaatttt 10981 tgtattttta gtagagatag ggtttcacca tattggtcgg gctggtctcg aactcctgac 11041 ctcaggtgat ccgacccgcc tcagcctccc aaagtgctgg gatcacaggc atgagccacc 11101 atagctggcc tgcttttagt ccaaaggaac aggggttggg ggaagttccc agggcttgag 11161 aggtcttgaa gccaaacagg ggttccaggg agactagggt gcccactctg gcattttctc 11221 tccttccctt caattcacag actctggtgg agcaacgttc aggtggttca ggaaagggca 11281 gcaataaggt gagatctgga cagaggactc gaggcagggg gagcttgcca aagagccttc 11341 tgatgactat gtctttgcct gtcccagagg ggccactagg tgtgacagag gaactgcaca 11401 tcatcagctt cacggtcaaa tatacctacc agggtctgaa gcaggagctg aaagtgagtg 11461 aaaatggagg gcaaggagag agaaagcagc tttggaagaa ggcataagaa ggggataaac 11521 agaagcctct tggggagggt tagcactcct ttcctctaac aaatacctgc agctagaaac 11581 atcacatccc tctctgtgac tcctgtcttc tccccacaca cggacaccct ccctgtggtg 11641 attatttcca acatgaacca gctctcaatt gcctgggctt cagttctctg gttcaatttg 11701 ctcagcccaa accttcaggt aggggagtgg ggccgacagg tcccggcgcg agagcagggg 11761 tgtggaagct tggtgtgata ggttgcttct gagccagcct acactgctcc cacccctgca 11821 gaaccagcag ttcttctcca acccccccaa ggccccctgg agcttgctgg gccctgctct 11881 cagttggcag ttctcctcct atgttggccg aggcctcaac tcagaccagc tgagcatgct 11941 gagaaacaag ctgttcggta cagatttcct tttctctcag cctttcccca gccttagtct 12001 tttctgtccc tctgtcctat ctatcccagg acccctggct tccctcacat atctgtggct 12061 atctgtccca cagggcagaa ctgtaggact gaggatccat tattgtcctg ggctgacttc 12121 actaaggtaa ctccctgaat cctgtggagc tgctggatct agccccacat tccaaatact 12181 ggccttccca cgtgccctcc ttccctacac cagaggcaac tcctcagctt ttgctacctt 12241 tccattcctc cagcgagaga gccctcctgg caagttacca ttctggacat ggctggacaa 12301 aattctggag ttggtacatg accacctgaa ggatctctgg aatgatgggt aaggccttgg 12361 tcacccttcc ctcatgggct tgtgcttccg ggcttgagag tggagtctct gcaccctcac 12421 gtggcaagca gggagagaga gcaaagcacg gtgcaggcca cgtctcctca catttgttaa 12481 gaataataag gccgggtgtg gtggctcaca cctgtaatcc cagcactttg ggaggccgag 12541 gcgggcggat catgaggtca ggagatcgag accatcctgg ctaacacggt gaaaccccgt 12601 ctctactcta aaaatacaaa aaattagccg ggcgtggagg cagacaccct gtagtcccag 12661 ctactcagga ggctgaggca ggaaaatggc gtgaacctgg gagatggagc ttgcagtgag 12721 ccgagattgc gtcactgccc tccagccttg gggtgacgta gcaagactcc gtctcaaaaa 12781'aaaaaaaaaa aaacaaccaa taatagccat aaacagtgtt tttgtgaagc actcctacat 12841 tccagagctt gatgggtgct cttcattaat tctctcatct catccttaca accatgctga 12901 gtggtgggtt ttgccagctt catttcatgt gaggaaactg agtttcagag aagttaaaga 12961 acttacccaa gggacacagt tgatattcaa atccaggcct atgtgactcc aagcccatgc 13021 tctttccacc acactgccta ccaacttgtg tagcatttgg cttttaaaag tgctattcat 13081 gaccaggcac gatggctcac gccttgtaat cccagcattt tgggaggccg aggtgggtgg 13141 atcacctgag gtcaggagtt tgagaccagc ctggccaaca tggcgaaacc ccatctctat 13201 taaaaataca aaaattagcc gggtgtggtg gtgggcgcct gtaatcccag ctactcagga 13261 ggctgaggag gagaatcgct tgaatttagg agagaaggtt acagtgagcc aagatcggc WO 00/09525 PCT/US99/17712 EPI-109 794 13321 cattgcactc cagcctggt gacagagcaa gactctgtct caaaacaaaa ccaaaaaaaa 13381 gtgctatttg tggccagacg tggttgctca tgcctgtaat cctagcattt ttggggaggc 13441 tgaggagtac agatcactg agcccaggag ttcaaaacta ccctgggcca cgtggtgaaa 13501 ccccaaaccc cgtctctacg aaaaatacaa aagttagcca ggatgggtgg tgtgcacctg 13561 tggtcccagc tactctggag gctgagaggt ggggaagatt gcttgagccc gggaggtcga 13621 ggtggcagtg agctgtgatc atgccactat tctccagcct gggtgacaga atacaccctg 13681 tctccctgtc tcccagaaaa aaaaaaaagt gctgttcatc tgtgtgatct cactgaatct 13741 tcgtacttca aaccctcgga aggtggctat tgtcagcaaa gtgaagtgac ttgtaaaaga 13801 taaaaaaaag ctaagtggca gggcttggtc caaagcctgg attccaaacc tgggctgttt 13861 ctccatacaa ggggagcagg gaggcagggg cctggggggg cagggtgttg ggcggtgtca 13921 cacgtgacac actgtgctcc agacgcatca tgggctttgt gagtcggagc caggagcgcc 13981 ggctgctgaa gaagaccatg tctggcacct ttctactgcg cttcagtgaa tcgtcagaag 14041 ggggcattac ctgctcctgg gtggagcacc aggatgatgg tagctgctct gccctgccat 14101 tcccacagcc tctcctttct gcctggctct cctctggccc ctctgcctgc cttgcttcgc 14161 tggctctgaa ctgaatgctc agtggtttgg gactgggcag ccagagagtc agagagctcc 14221 aaggcccggc ctcttccctc aagcccgcct gttcctgcat tcactctcca gacaaggtgc 14281 tcatctactc tgtgcaaccg tacacgaagg aggtgctgca gtcactcccg ctgactgaaa 14341 tcatccgcca ttaccagttg ctcactgagg agaatatacc tgaaaaccca ctgcgcttcc 14401 tctatccccg aatcccccgg gatgaagctt ttgggtgcta ctaccaggag aaaggtggga 14461 atcgttgaca tacttcattg ctagattgca gagatctacc agacatccat agatcccact 14521 ccttccttta aagcatggga aaactgatat ctagaggaat taagggattc gtccatggga 14581 tactgctggt tactatgggg atgagactgc caggaccatc tgcactaggg gaaaacctca 14641 ggctatatgt ctggcccact gatcttctct gcttcttgta tatgttcctc acagttaatc 14701 tccaggaacg gaggaaatac ctgaaacaca ggctcattgt ggtctctaat agagtgagat 14761 atgaactgtt cattcatcct ccctaatcct tattggctct gcttcagtga atcgtcaaaa 14821 gggggcatta ccttctcctg ggtggagcac caggatgatg gtcagctgct ctgccctgcc 14881 attcccacag cctctccttt ctgccttctc ctaagctgcc cctattccag tctccccagc 14941 cttccctccc tcctagcccc actctagttt tttctggttc tagtctctcc tatctcatat 15001 ttttctgctg ccatccttag gttgtctcca caggggtttc tggataataa tgatcataat 15061 cactggtgtt aaggggtacc tacttgatgc aagcatggag cttttttttt ttccagacag 15121 ggttttgttc tgtcgcccag gctggagtgc agtggtgtga tcctggctca ctgcagcctc 15181 gacctcctga gctcaagcaa tacaggcatg catcaccaaa ctcagctaat tttttttgta 15241 ttttttgtag agatggggtc ttaccatgtt gacgcatcag gctgttctga actcctggac 15301 tcaaqcaatc cacccacctt ggcctcccaa aagtcaggga ttacaggcgt gcgaccacac 15361 cccgcatata tatatttttt tttttttttt tttttttttt tttttgagac agggtctctg 15421 ttatccaggc tggagttgca gtggataata tgactacgag ccttgaccta ggggttgaag 15481 caatgctcct gcctcagcca ccaagtgctg agactacagg cacacgccaa tctacactca 15541 atcacactca gctaattttt taaatttttt gtagggatgg ggtatcactg tgtttgccca 15601 ggctggtctt gaactcctgg cctcaagcag tctcctgcct tggcctccca aattgccggg 15661 attgtaggaa tgagccatgg cacttggctg ggggatagaa tttttttttt tttttttttt 15721 tttttttttt ttgagacagt ctcactctca ttgcccgggc tggagtgcag tggtgcaatt 15781 tcagctcact gcaacctctg cctcccaggc tcaagcaatt ctcctgcctc agcctataga 15841 gtagctggga ttacaggcga gcgccaccca tgcctggtta atttttgttt tttttttgag 15901 acagagtctc gccctgttgc ccaggctgga gtgcagtggc acgatctcag ctcactgcaa 15961 cctctgcctc ccaggctcaa gcaattctcc tgcctcagcc tcctgagtac tgggactaca 16021 agcgcgcaca accaccacac ctggtaattt ttgtattttt agtagagaca gggttttacc 16081 atattggcca ggctggtctc aaactcctga cctcatgatc cgacccacct tggcctccca 16141 aagtgcaggg attacaggcg tgagcctctg cacccggcct aacttttgta tttttagtag 16201 aaacagggtt tcaccatgtt ggccaggctg gtcatgagct cctggcctca agtgatctgc 16261 ccgcctcagc ctcccaaagt gcttggatta caggtgtgag ccacctggcc tgagagttta 16321 ttatgcgcca ggcactaggc aaatggtttg catttatttt ctcattttat tgaatctaca 16381 aaatagtcct gtgaagtaaa cactgttact gttttcagct aaggaactgg atttagagta 16441 gtcaagtttt gtacctaagg tacgtggcta atgatacagg tctgttagat tccgtagccc 16501 tgattttaac caccctactg cctctcaaga attactaggt attgttctca tttatagatg 16561 ataaatctga ggctcagaaa agttaggcca cttgcctaag gtcccccagc caggattcaa 16621 actccaggag gcctgattcc aaacccatgc tctttagccc tccgccctac tgccttctta 16681 gactagcttc tgcttattct accattcctg atttcatttg aaccactgag ccctgcccct 16741 ttgtctgtct ttgggtatcc aggcaggtgg atgaactgca acaaccgctg gagcttaagc 16801 cagagccaga gctggagtca ttagagctgg aactagggct ggtgccagag ccagagctca 16861 gcctggactt agagccaccg ctgaaggcag ggctggatct ggggccagag ctagagtctg 16921 tgctggagtc cactctggag cctgtgatag agcccacact atgcatggta tcacaaacag 16981 tgccagagcc agaccaagga cctgtatcac agccagtgcc agagccagat ttgccctgtg 17041 atctgagaca tttgaacact gagccaatgg aaagtaagtg atgagatgga gtggcacaca 17101 ttccctttcc tacctcttct ccctctccca ttacagaaaa agctgaactc caagctcctc 17161 attggagaga ggtccatcg tgattccttt ttttaggaat tacacatgcc ttcccccacc 17221 tccctgctct ttcatcccac aagttcccac tcaggctctt cccaggcctt tcctgccatc 17281 ctccctccct tgggctgctg ggttgggaac tcctaactaa gatcggggcc tcacttttct 17341 ctctggatta cctagtctc agaaactgtg taaagattga agaaatcatg ccgaatggtg WO 00/09525 PCT/US99/17712 EPI-109 795 17401 acccactgtt ggctggccag aacaccgtgg acgaggttta cgtctcccgc cccagccact 17461 tctacactga tggacccttg atgccttctg acttctagga accacatttc ctctgttctt 17521 ttcatatctc tttgcccttc ctactcctca tagcatgata ttgttctcca aggatgggaa 17581 tcaggcatgt gtcccttcca agctgtgtta actgttcaaa ctcaggcctg tgtgactcca 17641 ttggggtgag aggtgaaagc ataacatggg tacagagggg acaacaatga atcagaacag 17701 atgctgagcc ataggtctaa ataggatcct ggaggctgcc tgctgtgctg ggaggtatag 17761 gggtcctggg ggcaggccag ggcagttgac aggtacttgg agggctcagg gcagtggctt 17821 ctttccagta tggaaggatt tcaacatttt aatagttggt taggcraaac tggtgcatac 17881 tggcattggc cttggtgggg agcacagaca caggatagga ctccatttct ttcttccatt 17941 ccttcatgtc taggataact tgctttcttc tttcctttac tcctggctca agccctgaat 18001 ttcttctttt cctgcagggg ttgagagctt tctgccttag cctaccatgt gaaactctac 18061 cctgaagaaa gggatggata ggaagtagac ctctttttct taccagtctc ctcccctact 18121 ctgcccccta agctggctgt acctgttcct cccccataaa atgatcctgc caatctaatg 18181 tgagtgtgaa gtttgcacac tagtttatgc tacctagtct ccactttctc aatgcttagg 18241 agacagatca ctcctggagg ctggggatgg taggattgct ggggattttt ttttttttaa 18301 agagggtctc actctgttgc ccaggctaga gtgcaatggt gcaatcacag ctcactgcag 18361 cctcaacctc ctgggttcaa gcaatcctcc tacctcagcc tcctgggtag ctagcaccat 18421 ggcatcgcca ccatgcccta tttttttttt ttaaagacag ggtcttgcta tattgcccag 18481 gctggtcttg aactgggctc aagtgatcct cacgccttgc ctcccaaagt gctgggatta 18541 taggcatgag ccactgtgct tggccaggat tttttttttt ttttttttga gatggagttt 18601 ctctcttgtt gtccaggctg gagtgcaatg gtgtgatccg gggaattc (2) INFORMATION FOR SEQ ID NO:2627: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 2761 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2627 1 cagctggaat tcggggcggc ggcgcagact gggaggggga gccgggggtt ccgacgtcgc 61 agccgaggga acaagcccca accggatcct ggacaggcac cccggcttgg cgctgtctct 121 ccccctcggc tcggagaggc ccttcggcct gagggagcct cgccgcccgt ccccggcaca 181 cgcgcagccc cggcctctcg acctctgccg gagaaacagg atggcccaat ggaatcagct 241 acagcagctt gacacacggt acctggagca gctccatcag ctctacagtg acagcttccc 301 aatggagctg cggcagtttc tggccccttg gattgagagt caagattggg catatgcggc 361 cagcaaagaa tcacatgcca ctttggtgtt tcataatctc ctgggagaga ttgaccagca 421 gtatagccgc ttcctgcaag agtcgaatgt tctctatcag cacaatctac gaagaatcaa 481 gcagtttctt cagagcaggt atcttgagaa gccaatggag attgcccgga ttgtggcccg 541 gtgcctgtgg gaagaatcac gccttctaca gactgcagcc actgcggccc agcaaggggg 601 ccaggccaac caccccacag cagccgtggt gacggagaag cagcagatgc tggagcagca 661 ccttcaggat gtccggaaga gagtgcagga tctagaacag aaaatgaaag tggtagagaa 721 tctccaggat gactttgatt tcaactataa aaccctcaag agtcaaggag acatgcaaga 781 tctgaatgga aacaaccagt cagtgaccag gcagaagatg cagcagctgg aacagatgct 841 cactgcgctg gaccagatgc ggagaagcat cgtgagtgag ctggcggggc ttttgtcagc 901 gatggagtac gtgcagaaaa ctctcacgga cgaggagctg gctgaczgga agaggcggca 961 acagattgcc tgcattggag gcccgcccaa catctgccta gatcggctag aaaactggat 1021 aacgtcatta gcagaatctc aacttcagac ccgtcaacaa attaagaaac tggaggagtt 1081 gcaccaaaaa gtttcctaca aaggggaccc cattgtacag caccggccga tgctggagga 1141 gaggatcgtg gagctgttca gaaacttaat gaaaagtgcc tttgtggtgg agcggcagcc 1201 ctgcatgccc atgcatccg accqgcccct cgtcatcaag accggcgtcc agttcactac 1261 taaagtcagg ttgctggtca agttccctga gttgaattat cagcttaaaa ttaaagtgtg 1321 cattgacaaa gactctgggg acgttgcagc tctcagagga tcccggaaat ttaacattct 1381 gggcacaaac acaaaagtga tgaacatgga agaatccaac aacggcagcc tctctgcaga 1441 attcaaacac ttqaccctga gggagcagag atgtgggaat gggggccgag ccaattgtga 1501 tgcttccctg attgtgactg aggagctgca cctgatcacc tttgagaccg aggtgtatca 1561 ccaaggtctc aagattgacc tagagaccca ctccttgtca gttgtggtga tctccaacat 1621 ctgtcagatg ccaaatgcct gggcgtccat cctgtggtac aacatgctga ccaacaatcc 1681 caagaatgtg aacttcttca ctaagccgcc aattggaacc tgggaccaag tggccgaggt 1741 gctcagctgg cagttctcgt ccaccaccaa gcgggggctg agcatcgagc agctgacaac 1801 gccggctgag aagctcctag ggcctggtgt gaactactca gggtgtcaga tcacatgggc 1861 taacttctgc aaagaaaaca tggctggcaa gggcttctcc tactgggtct ggctagacaa 1921 tatcatcgac cttgtgaaaa agtatatctt ggccctttgg aatgaagggt acatcatggg 1981 tttcatcagc aaggagcggg agcgggccat cttgagcact aagcccccag gcaccttcct 2041 gctgcgcttc agtgaaagca gcaaagaagg aggcgtcact ttcacttggg tggagaagga 2101 catcagcggt aagacccaga tccagtccgt ggaaccatac acaaagcagc agctgaacaa 2161 catgtcattt gctgaaatca tcatgggcta taagatcatg gatgctacca atatcctgtt 2221 gtctccactt gtccatctct atcctgacat tcccaaggag gaggcattcg ggaagtattg 2281 tcggccagag agccaggagc atcctgaagc tgacccaggt agcgctgccc catacctgaa 2341 gaccaagttt atctgtgtga caccaacgac ctgcagcaat accattgacc tgccgatgtc WO 00/09525 PCTIUS99/17712 EPI-109 796 2401 cccccgcgct ttagattcat tgatgcagtt tggaaataat ggtgaaggtg ctgaaccctc 2461 agcaggaggg cagtttgagt ccctcacctt tgacatggag ttgacctcgg agtgcgctac 2521 ctcccccatg tgaggagctg agaacggaag ctgcagaaag atacgactga ggcgcctacc 2581 tgcattctgc cacccctcac acagccaaac cccagatcat ctgaaactac taactttgtg 2641 gttccagatt ttttttaatc tcctacttct gctatctttg agcaatctgg gcacttttaa 2701 aaatagagaa atgagtgaat gtgggtgatc tgcttttatc taaatgcaaa taaggatgtg 2761 ttctctgaga cccatgatca ggggatg (2) INFORMATION FOR SEQ ID NO:2628: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 181 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2628 1 cgacagcgac cagatcaagg aggaactgcc ggagcccttt gagcatcttc tgcagagaat 61 cgcccggaga cccaagcctc agcagttctt tggattaatg ggcaaacggg atgctggaca 121 tggccagatc tctcacaaaa gacataaaac agattccttt gttggactaa tgggcaaaag 181 agctttaaat tctgtggctt atgaaaggag tgcaatgca (2) INFORMATION FOR SEQ ID NO:2629: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1021 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2629 1 gagagtgcgg agcgaccacg tgcgctcgga ggaaccagag aaactcagca ccccgcggga 61 ctgtccgtcg caaaatccaa catgaaaatc ctcgtggcct tggcagtctt ttttcttgtc 121 tccactcagc tgtttgcaga agaaatagga gccaatgatg atctgaatta ctggtccgac 181 tggtacgaca gcgaccagat caaggaggaa ctgccggagc cctttgagca tcttctgcag 241 agaatcgccc ggagacccaa gcctcagcag ttctttggat taatgggcaa acgggatgct 301 gattcctcaa ttgaaaaaca agtggccctg ttaaaggctc tttatggaca tggccagatc 361 tctcacaaaa gacataaaac agattccttt gttggactaa tgggcaaaag agctttaaat 421 tctgtggctt atgaaaggag tgcaatgcag aattatgaaa gaagacgtta ataaactacc 481 taacattatt tattcagctt catttgtgtc aatgggcaat gacaggtaaa ttaagacatg 541 cactatgagg aataattatt tatttaataa caattgttta gggttgaaaa ttcaaaaagt 601 gtttattttt catattgtgc caatatgtat tgtaaacatg tgttttaatt ccaatatgat 661 gactccctta aaatagaaat aagtggttat ttctcaacaa agcacagtgt taaatgaaat 721 tgtaaaacct gtcaatgata cagtccctaa agaaaaaaaa tcattgcttt gaagcagttg 781 tgtcagctac tgcggaaaag gaaggaaact cctgacagtc ttgtgctttt cctatttgtt 841 ttcatggtga aaatgtactg agattttggt attacactgt atttgtatct ctgaagcatg 901 tttcatgttt tgtgactata tagagatgtt tttaaaagtt tcaatgtgat tctaatgtct 961 tcatttcatt gtatgatgtg ttgtgatagc taacatttta aataaaagaa aaaatatctt 1021 g (2) INFORMATION FOR SEQ ID NO:2630: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 2581 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2630 1 gcgccgcaag gcactgagca ggcgaaagag cgcgctcgga cctccttccc ggcggcagct 61 accgagagtg cggagcgacc agcgtgcgct cggaggaacc agagaaactc agcaccccgc 121 gggactgtcc gtcgcaaaat ccaacatgaa aatcctcgtg gccttggcag tcttttttct 181 tgtctccact cagctgtttg cagaagaaat aggagccaat gatgatctga attactggtc 241 cgactggtac gacagcgacc agatcaagga ggaactgccg gagccctttg agcatcttct 301 gcagagaatc gcccggagac ccaagcctca gcagttcttt ggattaatgg gcaaacggga 361 tgctgattcc tcaattgaaa aacaagtggc cctgttaaag gctctttatg gacatggcca 421 gatctctcac aaaagacata aaacagattc ctttgttgga ctaatgggca aaagagcttt 481 aaattctgtg gcttatgaaa ggagtgcaat gcagaattat gaaagaagac gttaataaac 541 tacctaacat tatttattca gcttcatttg tgtcaatggg caatgacagg taaattaaga 601 catgcactat gaggaataat tatttattta ataacaattg tttggggttg aaaattcaaa 661 aagtgtttat ttttcatatt gtgccaatat gtattgtaaa catgtgtttt aattccaata 721 tgatgactcc cttaaaatag aaataagtgg ttatttctca acaaagcaca gtgttaaatg 781 aaattgtaaa acctgtcaat gatacagtcc ctaaagaaaa aaaatcattg ctttgaagca 841 gttgtgtcag ctactgcgga aaaggaagga aactcctgac agtcttgtgc ttttcctatt 901 tgttttcatg gtgaaaatgt actgagattt tggtattaca ctgtatttgt atctctgaag 961 catgtttcat gttttgtgac tatatagaga tgtttttaaa agtttcaatg tgattctaat WO 00/09525 PCT/US99/17712 EPI-109 797 1021 gtcttcattt cattgtatga tgtgttgtga tagctaacat tttaaataaa agaaaaaata 1081 tcttgaaaaa aaaaaaaaaa aa (2) INFORMATION FOR SEQ ID NO:2631: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 2283 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2631 1 cgacagcgac cagatcaagg aggaactgcc ggagcccttt gagcatcttc tgcagagaat 61 cgcccggaga cccaagcctc agcagttctt tggattaatg ggcaaacggg atgctggaca 121 tggccagatc tctcacaaaa gacataaaac agattccttt gttggactaa tgggcaaaag 181 agctttaaat tctgtggctt atgaaaggag tgcaatgca 1 gagagtgcgg agcgaccacg tgcgctcgga ggaaccagag aaactcagca ccccgcggga 61 ctgtccgtcg caaaatccaa catgaaaatc ctcgtggcct tggcagtctt ttttcttgtc 121 tccactcagc tgtttgcaga agaaatagga gccaatgatg atctgaatta ctggtccgac 181 tggtacgaca gcgaccagat caaggaggaa ctgccggagc cctttgagca tcttctgcag 241 agaatcgccc ggagacccaa gcctcagcag ttctttggat taatgggcaa acgggatgct 301 gattcctcaa ttgaaaaaca agtggccctg ttaaaggctc tttatggaca tggccagatc 361 tctcacaaaa gacataaaac agattccttt gttggactaa tgggcaaaag agctttaaat 421 tctgtggctt atgaaaggag tgcaatgcag aattatgaaa gaagacgtta ataaactacc 481 taacattatt tattcagctt catttgtgtc aatgggcaat gacaggtaaa ttaagacatg 541 cactatgagg aataattatt tatttaataa caattgttta gggttgaaaa ttcaaaaagt 601 gtttattttt catattgtgc caatatgtat tgtaaacatg tgttttaatt ccaatatgat 661 gactccctta aaatagaaat aagtggttat ttctcaacaa agcacagtgt taaatgaaat 721 tgtaaaacct gtcaatgata cagtccctaa agaaaaaaaa tcattgcttt gaagcagttg 781 tgtcagctac tgcggaaaag gaaggaaact cctgacagtc ttgtgctttt cctatttgtt 841 ttcatggtga aaatgtactg agattttggt attacactgt atttgtatct ctgaagcatg 901 tttcatgttt tgtgactata tagagatgtt tttaaaagtt tcaatgtgat tctaatgtct 961 tcatttcatt gtatgatgtg ttgtgatagc taacatttta aataaaagaa aaaatatctt 1021 g 1 gcgccgcaag gcactgagca ggcgaaagag cgcgctcgga cctccttccc ggcggcagct 61 accgagagtg cggagcgacc agcgtgcgct cggaggaacc agagaaactc agcaccccgc 121 gggactgtcc gtcgcaaaat ccaacatgaa aatcctcgtg gccttggcag tcttttttct 181 tgtctccact cagctgtttg cagaagaaat aggagccaat gatgatctga attactggtc 241 cgactggtac gacagcgacc agatcaagga ggaactgccg gagccctttg agcatcttct 301 gcagagaatc gcccggagac ccaagcctca gcagttcttt ggattaatgg gcaaacggga 361 tgctgattcc tcaattgaaa aacaagtggc cctgttaaag gctctttatg gacatggcca 421 gatctctcac aaaagacata aaacagattc ctttgttgga ctaatgggca aaagagcttt 481 aaattctgtg gcttatgaaa ggagtgcaat gcagaattat gaaagaagac gttaataaac 541 tacctaacat tatttattca gcttcatttg tgtcaatggg caatgacagg taaattaaga 601 catgcactat gaggaataat tatttattta ataacaattg tttggggttg aaaattcaaa 661 aagtgtttat ttttcatatt gtgccaatat gtattgtaaa catgtgtttt aattccaata 721 tgatgactcc cttaaaatag aaataagtgg ttatttctca acaaagcaca gtgttaaatg 781 aaattgtaaa acctgtcaat gatacagtcc ctaaagaaaa aaaatcattg ctttgaagca 841 gttgtgtcag ctactgcgga aaaggaagga aactcctgac agtcttgtgc ttttcctatt 901 tgttttcatg gtgaaaatgt actgagattt tggtattaca ctgtatttgt atctctgaag 961 catgtttcat gttttgtgac tatatagaga tgtttttaaa agtttcaatg tgattctaat 1021 gtcttcattt cattgtatga tgtgttgtga tagctaacat tttaaataaa agaaaaaata 1081 tcttgaaaaa aaaaaaaaaa aa (2) INFORMATION FOR SEQ ID NO:2632: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1621 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2632 1 gaaaaagcct tccacccacc tgtctggctt tagaaggacc ctgagcccca ggcgccacga 61 caggactctg ctgcagaggg gggttgtgta cagatagtag ggctttaccg cctagcttcg 121 aaatggataa cgtcctcccg gtggactcag acctctcccc aaacatctcc actaacacct 181 cggaacccaa tcagttcgtg caaccagcct ggcaaattgt cctttgggca gctgcctaca 241 cggtcattgt ggtgacctct gtggtgggca acgtggtagt gatgtggatc atcttagccc 301 acaaaagaat gaggacagtg acgaactatt ttctggtgaa cctggccttc gcggaggcct 361 ccatggctgc attcaataca gtggtgaact tcacctatgc tgtccacaac gaatggtact 421 acggcctgtt ctactgcaag ttccacaact tcttccccat cgccgctgtc ttcgccagta 481 tctactccat gacggctgcg gcctttgata ggtacatggc catcatacat cccctccagc WO 00/09525 PCT/US99/17712 EPI-109 798 541 cccggctgtc agccacagcc accaaagtgg tcatctgtgt catctgggtc ctggctctcc 601 tgctggcctt cccccagggc tactactcaa ccacagagac catgcccagc agagtcgtgt 661 gcatgatcga atggccagag catccgaaca agatttatga gaaagtgtac cacatctgtg 721 tgactgtgct gatctacttc ctccccctgc tggtgattgg ctatgcatac accgtagtgg 781 gaatcacact atgggccagt gagatccccg gggactcctc tgaccgctac cacgagcaag 841 tctctgccaa gcgcaaggtg gtcaaaatga tgattgtcgt ggtgtgcacc ttcgccatct 901 gctggctgcc cttccacatc ttcttcctcc tgccctacat caacccagat ctctacctga 961 agaagtttat ccagcaggtc tacctggcca tcatgtggct ggccatgagc tccaccatgt 1021 acaaccccat catctactgc tgcctcaatg acaggttccg tctgggcttc aagcatgcct 1081 tccggtgctg ccccttcatc agcgccggcg actatgaggg gctggaaatg aaatccaccc 1141 ggtatctcca gacccagggc agtgtgtaca aagtcagccg cctggagacc accatctcca 1201 cagtggtggg ggcccacgag gaggagccag aggacggccc caaggccaca ccctcgtccc 1261 tggacctgac ctccaacrgc tcttcacgaa gtgactccaa gaccatgaca gagagcttca 1321 gcttctcctc caatgtgctc tcctaggcca cagggccttt ggcaggtgca gcccccactg 1381 cctttgacct gcctcccttc atgcatggaa attcccttca tctggaacca tcagaaacac 1441 cctcacactg ggacttgcaa aaagggtcag tatgggttag ggaaaacatt ccatccttga 1501 gtcaaaaaat ctcaattctt ccctatcttt gccaccctca tgctgtgtga ctcaaaccaa 1561 atcactgaac tttgctgagc ctgtaaaata aaaggtcgga ccagcttttc ccaaaagccc 1621 attcattcca ttctggaagt gactttggct gcatgcgagt gctcatttca ggat (2) INFORMATION FOR SEQ ID NO:2633: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 2581 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2633 1 aattcagagc caccgcgggc aggcgggcag tgcatccaga agcgtttata ttctgagcgc 61 cagttcagct ttcaaaaaga gtgctgccca taaaaagcct tccaccctcc tgtctgcttt 121 agaaggaccc tgagccccag gcgccagcca caggactctg ctgcagaggg gggttgtgta 181 cagatagtag gctttacgcc tagcttcgaa atggataacg tcctcccggt ggactcagac 241 ctctccccaa acatctccac taacacctcg gaacccaatc agttcgtgca accagcctgg 301 caaattgtcc tttgggcagc tgcctacacg gtcattgtgg tgacctctgt ggtgggcaac 361 gtggtagtga tgtggatcat cttagcccac aaaagaatga ggacagtgac gaactatttt 421 ctggtgaacc tggccttcgc ggaggcctcc atggctgcat tcaatacagt ggtgaacttc 481 acctatgctg tccacaacga atggtactac ggcctgttct actgcaagtt ccacaacttc 541 tttcccatcg ccgctgtctt cgccagtatc tactccatga cggctgtggc ctttgatagg 601 tacatggcca tcatacatcc cctccagccc cggctgtcag ccacagccac caaagtggtc 661 atctgtgtca tctgggtcct ggctctcctg ctggccttcc cccagggcta ctactcaacc 721 acagagacca tgcccagcag agtcgtgtgc atgatcgaat ggccagagca tccgaacaag 781 atttatgaga aagtgtacca catctgtgtg actgtgctga tctacttcct ccccctgctg 841 gtgattggct atgcatacac cgtagtggga atcacactat gggccagtga gatccccggg 901 gactcctctg accgctacca cgagcaagtc tctgccaagc gcaaggtggt caaaatgatg 961 attgtcgtgg tgtgcacctt cgccatctgc tggctgccct tccacatctt cttcctcctg 1021 ccctacatca acccagatct ctacctgaag aagtttatcc agcaggtcta cctggccatc 1081 atgtggctgg ccatgagctc caccatgtac aaccccatca tciactgctg cctcaatgac 1141 aggttccgtc tgggcttcaa gcatgccttc cggtgctgcc ccttcatcag cgccggcgac 1201 tatgaggggc tggaaatgaa atccacccgg tatctccaga cccagggcag tgtgtacaaa 1261 gtcagccgcc tggagaccac catctccaca gtggtggggg cccacgagga ggagccagag 1321 gacggcccca aggccacacc ctcgtccctg gacctgacct ccaactgctc ttcacgaagt 1381 gactccaaga ccatgacaga gagcttcagc ttctcctcca atgtgctctc ctaggccaca 1441 gggcctttgg caggtgcagc ccccactgcc tttgacctgc ctcccttcat gcatggaaat 1501 tcccttcatc tggaaccatc agaaacaccc tcacactggg acttgcaaaa agggtcagta 1561 tgggttaggg aaaacattcc atccttgagt caaaaaatct caattcttcc ctatctttgc 1621 caccctcatg ctgtgtgact caaaccaaat cactgaactt tgctgagcct gtaaaataaa 1681 aggtcggacc agcttttcct caagagccca atgcattcca tttctggaag tgactttggc 1741 tgcatgcgag tgctcatttc aggatg (2) INFORMATION FOR SEQ ID NO:2634: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 2581 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2634 1 gaaaaagcct tccaccctcc tgtctggctt tagaaggacc ctgagcccca ggcgccacga 61 caggactctg ctgcagaggg gggctgtgta cagatagtag ggctttaccg cctagcttcg 121 aaatggataa cgtcctcccg gtggactcag acctctcccc aaacatctcc actaacacct 181 cggaacccaa tcagttcgcg caaccagcct ggcaaattgcctttgggca gctgcctaca WO 00/09525 PCTIUS99/17712 EPI-109 799 241 cggtcattgt ggtgacctct gtggtgggca acgtggtagt gatgtaatc atcttagccc 301 acaaaagaat gaggacagtg acgaactatt ttctggtgaa cctggce:tc gcggaggcct 361 ccatggctgc attcaataca gtggtgaact tcacctatgc tgtccacaac gaatggtact 421 acggcctgtt ctactgcaag ttccacaact tcttccccat cgccgctgtc ttcgccagta 481 tctactccat gacggctgtg gcctttgata ggtacatggc catcatacat cccctccagc 541 cccggctgtc agccacagcc accaaagtgg tcatctgtgt catctgggtc ctggctctcc 601 tgctggcctt cccccagggc tactactcaa ccacagagac catgcccagc agagtcgtgt 661 gcatgatcga atggccagag catccgaaca agatttatga gaaagztac cacatctgtg 721 tgactgtgct gatctacttc ctccccctgc tggtgattgg ctatgcarac accgtagtgg 781 gaatcacact atgggccagt gagatccccg gggactcctc tgaccgtrac cacgagcaag 841 tctctgccaa gcgcaaggtg gtcaaaatga tgattgtcgt ggtgtgcacc ttcgccatct 901 gctggctgcc cttccacatc ttcttcctcc tgccctacat caacccagat ctctacctga 961 agaagtttat ccagcaggtc tacctggcca tcatgtggct ggccatgagc tccaccatgt 1021 acaaccccat catctactgc tgcctcaatg acaggtgagg atcccaaccc catgagctct 1081 ccaggggcca caagaccatc tacatacaca gtggccaagc ggcatc:taa atgagtaaac 1141 ccagctgtga gacaagaggg acaagtgggg actgcagcta acttatcatc acacaactca 1201 gcctggctga ttatcaccat ccaggaatgg gagcccggag tagactgatt ttcttttttt 1261 cttttcca (2) INFORMATION FOR SEQ ID NO:2635: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2635 1 atgctgagaa aggtagctgc caaaccttga ctgcaataac aataacaaaa attaaaaacc 61 taaaataata agtatatcat actgaccttt cctgtttacc ttgctgzagg taccacatct 121 gtgtgactgt gctgatctac ttcctccccc tgctggtgat tggctazgca tacaccgtag 181 tgggaatcac actatgggcc agtgagatcc ccggggactc ctctgaccgc taccacgagc 241 aagtctctgc caagcgcaag gtgagcaggg gacaggcaga actaacccac cctggcacag 301 acaacaggct gtcgagaagg gatggcacac ttgtgagccc cagaggcagc tagcacaaaa 361 tatccccagg tat (2) INFORMATION FOR SEQ ID NO:2636: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2636 1 ggatccaatt tttgcccggc ataagtgtat agtaaatttc ccagccttaa agcacttccc 61 gagagatgct ttgagcgctc gcggtaccag tgcgtaaacg ccgctccccg gctggcgcgg 121 gtgtgcgcca actccaacct gcgcgcaagt ctgccggtgc gcgctccagt cccacagctc 181 cgagtccccg cagtgaaagg agggggcggt gcaccggggt agatggccc ctgaggactc 241 ccggggttca gttttccgcg gctgccaaga gggccaagtt ggacag-ggc agggtcctga 301 agcagatcag caacaaccgc aagtgctcca gccccaggtc ctcagacacg gaggaaaacg 361 acaagaggcg gacacacaac gtcttggaac gtcagaggag gaacgaqctg aagcgcagct 421 tttttgccct gcgtgaccag atccctgaat tggaaaacaa cgaaaaagcc cccaaggtag 481 tgatcctcaa aaaagccacc gcctacatcc tgtccattca agcagacgag cacaagctca 541 cctctgaaaa ggacttattg aggaaacgac gagaacagtt gaaacacaaa ctcgaacagc 601 ttcgaaactc tggtgcataa actgacctaa ctcgaggagg agctggaatc tctcgtgaga 661 gtaaggagaa cggttccttc tgacagaact gatgcgctgg aattaaaatg catgctcaaa 721 gcctaacctc acaaccttgg ctggggcttt gggactgtaa gcttagagac tgtcacttcc 781 caggtgaatc agctagccag gtaactgagc tagatatttt gtgggggtgt ttcctaaaca 841 cagcctcagg aaagttgttt tcgggacacc tggaccaggg agtcgtcgcc tctggcttct 901 cggtagctgg agcgcggccc ggagcgcggc gctggcacat cgcccccaca catgaccgtt 961 tcccattgcc acaggcaagc cgcctctgca gagctgtctc agggcrctgg gcttcattcc 1021 ctggaagttg attgtcctcc actccagctg tttcccaaat ccttccztcc tcccagcacc 1081 cctcgtgcaa cgacgattcc agctgcggac cgcatctgtg tcagttactt ccaagccacc 1141 tactgccccc tcgcggagtg cgtggggctc ccggctcgca gactcccacg gcaagtagca 1201 agcagcaaaa ggcgtggtag ctgcggcggt ggaatgagac agttgzaac agctggcgca 1261 cgtgccgccg tgcgcaccgg gactggcgag tacgcagccc aggtaczgcc ccttcccagt 1321 gacgtctctg cagggggtta taaaagcctc gtgcgcagct aactcacgag ctgagcaacc 1381 cgaaccgaga ggtgcccgcg aaactgcagg cggcggcagc ggcagcaaaa gagaaggaaa 1441 aatctccagc tggatacgaa gctccagaat cctggccata ggctcaaaac ttttacaggt 1501 cgcgctgcaa tgggccccca cttcgctcct aagtcctcac gcagcacagg gctttgcctt 1561 tccctgcgga ggaaggagaa ataggagttg caggcagcag caggtgcata aatgcggggg 1621 atctcttgct tcctagaact gtgaccggtg gaatttcttt ccctttztca gtttaccgca WO 00/09525 PCT/US99/17712 EPI-109 800 1681 agagagatgc tgtctccaga cttctgaact caaacgtctc ctgaagcttg aaagtggagg 1741 aattcagagc caccgcgggc aggcgggcag tgcatccaga agcgtttata ttctgagcgc 1801 cagttcagct ttcaaaaaga gtgctgccca gaaaaagcct tccaccctcc tgtctggctt 1861 tagaaggacc ctgagcccca ggcgccagcc acaggactct gctgcagagg ggggttgtgt 1921 acagatagta gggctttacc gcctagcttc gaaatggata acgtcctccc ggtggactca 1981 gacctctccc caaacatctc cactaacacc tcggaaccca atcagttcgt gcaaccagcc 2041 tggcaaattg tcctttgggc agctgcctac acggtcattg tggtgacctc tgtggtgggc 2101 aacgtggtag tgatgtggat catcttagcc cacaaaagaa tgaggacagt gacgaactat 2161 tttctggtga acctggcctt cgcggaggcc tccatggctg cattcaatac agtggtgaac 2221 ttcacctatg ctgtccacaa cgaatggtac tacggcctgt tctactgcaa gttccacaac 2281 ttcttcccca tcgccgctgt cttcgccagt atctactcca tgacggctgt ggcctttgat 2341 aggtgagatt agcctttgtg aaaaggcgag aaagtgctca tagaggacca tggcattgct 2401 gtgaggtttg gaactgggtg gggtatgggt caagtggaag attggccact ctgagggttt 2461 ttttactgat ca (2) INFORMATION FOR SEQ ID NO:2637: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2637 1 agaatatgga aaaggaattg gaaaataatt gtacaaatca tcaggaatca aagggtttct 61 atgaattttc ttattggcag gaaaaatatg gaatctctga tacagatttt ggtgaccaga 121 tcagaacttt gttctttctt ctctgttcca ggtacatggc catcatacat cccctccagc 181 cccggctgtc agccacagcc accaaagtgg tcatctgtgt catctgggtc ctggctctcc 241 tgctggcctt cccccagggc tactactcaa ccacagagac catgcccagc agagtcgtgt 301 gcatgatcga atggccagag catccgaaca agatttatga gaaagtgtga gtagagatga 361 ctccccatgc caaagaaacg atggtgcagg ctgccttcct ggccccttct tgctctttct 421 ttctttccat attcttttgt tggtacagat ttaatgtgta tctgcaagca tttctcacat 481 ataccctcat atcaggttga tatgtccaca gttgtcaggg gactatagta tcccaaatac 541 tattctgagc attgaaagat aatttttgaa gtgtaagatc tagatcctgt tata (2) INFORMATION FOR SEQ ID NO:2638: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: - base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2638 1 gagggggatg tgctggtggt ctcacctgtc tcaccctctt gccaggtggt caaaatgatg 61 attgtcgtgg tgtgcacctt cgccatctgc tggctgccct tccacatctt cttcctcctg 121 ccctacatca acccagatct ctacctgaag aagtttatcc agcaggtcta cctggccatc 181 atgtggctgg ccatgagctc caccatgtac aaccccatca tctactgctg cctcaatgac 241 aggtgaggat cccaacccca tgagctctcc aggggccaca agaccatcta catacacagt 301 ggccaagcgg catctaaatg agtaaaccca gctgtgagac aagagggaca agtggggact 361 gcagctaact t (2) INFORMATION FOR SEQ ID NO:2639: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2639 1 ccgtcccaaa ggtcacctct tcatctgctc gctctccagg ttccgtctgg gcttcaagca 61 tgccttccgg tgctgcccct tcatcagcgc cggcgactat gaggggctgg aaatgaaatc 121 cacccggtat ctccagaccc agggcagtgt gtacaaagtc agccgcctgg agaccaccat 181 ctccacagtg gtgggggccc acgaggagga gccagaggac ggccccaagg ccacaccctc 241 gtccctggac ctgacctcca actgctcttc acgaagtgac tccaagacca tgacagagag 301 cttcagcttc tcctccaatg tgctctccta ggccacaggg cctttggcag gtgcagcccc 361 cactgccttt gacctgcctc ccttcatgca tggaaattcc cttcatctgg aaccatcaga 421 aacaccctca cactgggact tgcaaaaagg gtcagtatgg gttagggaaa acattccatc 481 cttgagtcaa aaaatctcaa ttcttcccta tctttgccac cctcatgctg tgtgactcaa 541 accaaatcac tgaactttgc tgagcctgta aaataaaagg tcggaccagc ttttcccaaa 601 agcccattca ttccattctg gaagtgactt tggctgcatg cgagtgctca tttcaggatg 661 aattctgcag cacagctgcg gacccggaag actcattttc ctggagcccc gtgttacttc 721 aataaagtta tctcagatta gcctcctgca gctggaggct cctatcaccc cagcctacgc 781 ttgacagggt gaacaaaaga aggcaccaca taacatctaa atgaaaaatt tagccctgtc 841 ttctaagcat ctgtgaaaag aaacatatgt attccccttt ttggcatctc agtatttcag WO 00/09525 PCTIUS99/17712 EPI-109 801 901 tacatttata catcatgaga ttgagaacct cgggcttcca cattatgtcc ccggtgactg 961 tcctgagcag ccgacgcaag cagaatatgt ccactgatac ctgctagttc tcttacagac 1021 caggaattgg gagacttgca ctacatttaa tgtgtagttg accctctttt cctacttgta 1081 aacaagggga ctgaactaga taatctaagt gttccttcga atcttaacat cccgtggttc 1141 aaggattgta tgagtttttt gtttgtttta caaaaaaaaa caaaacgaag aataaaagaa 1201 tagaaaagaa taggagcagt gagtcttgta actaataccc agttcctgga gatgtagcaa 1261 ctgctaaggc catctgtaac tatccatctc agacattctc cgatttatct taaaatcctg 1321 agtacattcc ttctcatgga aggttttggc ttttgacaga gcagaggact tcatgccaag 1381 gcctgcatcc atccagcttt agcaggcaga atttcatagc tgcagaacac tgtcagagaa 1441 gacaaatgtg ggctccctgc tttaaccttt tgggtatttt agggtggggg ccctaacctt 1501 cattcttagt tttacactag catcgtgctc atatgtgcga caagcaagaa ggctgcactt 1561 tgcagctgca cttctgggaa gagggcatct tgcatcttcc cttcagactc tctgaatgtc 1621 tcctccctgc tccatggctt tgccagcttc ctgtctctaa ggggtagaat gactcatcaa 1681 ccctaaagga cagtcagtct tccaagagcc atgaactgaa tgctttatat cctaatttag 1741 atttagagtt tccagaaggt gagcatgcag ttttgttttg tttttttttc tgtctcccaa 1801 atctgtgttt tttccagata tggctggaag cagaagcttc atgtaacatc catgaatgtc 1861 ctcctggtag tttgcataat ggatgcacat gtgccgcatc cataacatta aggggagaat 1921 aatgcatggt ttacagcctt tgccagccct gctggctcta attctaccag ggcatccaca 1981 ggcctggggg aagaagaaac agtataagcc agaaaacctc aagaactaca ttctctaaag 2041 cagcatggaa agttttaaat aaactaagtg aagccagatc attgcagata tataaatgga 2101 agacaaaatt tagaagcaac aaaagttagt gccctaagca ttagtcatac ttccaataga 2161 gaatcttgct gtgtatggat tactcacttt ggaagaatgt aaagagctaa catgattatg 2221 agaagtacct gagaagatgg tgtcaagaag ttggggacac cccatctatg gaagagaagg 2281 ttagagttga gctcaacgag gattaactga gtgcctcctc tggactttgc cctgaactgg 2341 gaacacacag cccctgcagc tcttgaagag cctaccttat tggccatcac taactaactc 2401 accagtccta gtgagtctaa gctgcccagc agtcttggag gcatctgaga ggacagattc 2461 tccacagaat tctaaaaacc cacactcaac atgggcagtc aagcaaagac tgggaccttt 2521 ggagagcctc tggaatgaga gttctctggg gtacttccaa agggagctgg cagtcagtcc 2581 aggggaccta aaggaatttg gttgaacagt atcatctctg tgcatagtaa gagggaatgt 2641 tgggtggtcc gggcagtttc caatatggca aagcatctgc ttggacagtg ccagcaagcc 2701 ttcctctgac ccagtctcca atgtccacta acttataaaa atgtcatcaa ctcccacatg 2761 tgagaaacac catgatttg~t actgtgcatg ggtcacattc ttattctaga aatqcatcac 2821 cctgtgttta tccaagtgtg tttacttggt gtaatgtcca gtagtaatag aatatgaaat 2881 atcaaggaac catctttgtt acgtgacttc caaaatgtga gatctcattg ctgtcactgt 2941 gatatttgta ttgtgtgaat ctcttcctcc tcttcctcct catgctttct cagggaggag 3001 ccctgatgta tatcatgaac tcacagttcc tagaccacag taattgaggg gcggtggggg 3061 ggcctttatc ggagaagcta gagaacaaga gtccttctcc tccttatccc ccaacaggac 3121 actaagagac aaggactgag tggaatcctg gagaaagggg actcaggaac tgacctcatt 3181 ggcctgattt gtgaggagag gagtataagt ggagaggggc cattcctgag gtttccgtgt 3241 tttccagcct ggtctcctgg aaagaatctt tatacagaaa taaagtatgt gtttcactct 3301 ctcgtgcctc tgtctcttct ctaggggtcc taaacatcct ataggatgct aaatgggatg 3361 gtactagaaa ccctaataac ttgcatagct agaaggatgg aatcaatgtt cagtaaactc 3421 ttgactctgt gatgaaatgg gttgggaaga tgtgggaaca gttcccaggt tgagatctgg 3481 gaagggaggt gggattatgc gaaatcacag tgatgttgcc tatgaataaa gctgtgtcag 3541 gatgcagaca caacagagtt ataagcacaa gggagttttc gtaggacagg aggttggggg 3601 gaataacatc tgagaaagac aaaggggaaa gaaagcagaa gtactcaggg acagccttca 3661 gaccaccatg ccaatctgac acctgggaaa aaaggggtgg ttaggaagag cctcagactg 3721 tggtgcagct cccagcccaa cacgtgcaaa gattgcccag agagacattg cacgttaaca 3781 gaatggccag gcctgatgcc ctgccgtgct cagccgctgg ctggggctct ctagggaaag 3841 tgttctgtgt ttgaacacca tggtggatgc tgaagccctg cagctggagg ctgtcagcca 3901 agtgccctgc agttcttcct aaagaggga (2) INFORMATION FOR SEQ ID NO:2640: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 2581 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2640 1 gaaaaagcct tccaccctcc tgtctggctt tagaaggacc ctgagcccca ggcgccacga 61 caggactctg ctgcagaggg gggttgtgta cagatagtag ggctttaccg cctagcttcg 121 aaatggataa cgtcctcccg gtggactcag acctctcccc aaacatctcc actaacacct 181 cggaacccaa tcagttcgtg caaccagcct ggcaaattgt cctttgggca gctgcctaca 241 cggtcattgt ggtgacctct gtggtgggca acgtggtagt gatgtggatc atcttagccc 301 acaaaagaat gaggacagtg acgaactatt ttctggtgaa cctggccttc gcggaggcct 361 ccatggctgc attcaataca gtggtgaact tcacctatgc tgtccacaac gaatggtact 421 acggcctgtt ctactgcaag ttccacaact tcttccccat cgccgctgtc ttcgccagta 481 tctactccat gacggctgtg gcctttgata ggtacatggc catcatacat cccctccagc 541 cccggctgtc agccacagcc accaaagtgg tcatctgtgt catctgggtc ctggctctcc WO 00/09525 PCT/US99/17712 EPI-109 802 601 tgctggcctt cccccagaac tactactcaa ccacagagac catgcccagc agagtcgtgt 661 gcatgatcga atggccaaag catccgaaca agatttatga gaaagtgtac cacatctgtg 721 tgactgtgct gatctacztc ctccccctgc tggtgattgg ctatgcatac accgtagtgg 781 gaatcacact atgggccagt gagatccccg gggactcctc tgaccgctac cacgagcaag 841 tctctgccaa gcgcaaggtg gtcaaaatga tgattgtcgt ggtgtgcacc ttcgccatct 901 gctggcrgcc cttccacarc ttcttcctcc tgccctacat caacccagat ctctacctga 961 agaagtttat ccagcaggtc tacctggcca tcatgtggct ggccaugagc tccaccatgt 1021 acaaccccat catctaczgc tgcctcaatg acaggttccg tctgggcttc aagcatgcct 1081 tccggtgctg ccccttcamtc agcgccggcg actatgaggg gctggaaatg aaatccaccc 1141 ggtatctcca gacccaaggc agtgtgtaca aagtcagccg cctggagacc accatctcca 1201 cagtggtggg ggcccacaag gaggagccag aggacggccc caaggccaca ccctcgtccc 1261 tggacctgac ctccaactac tcttcacgaa gtgactccaa gaccatgaca gagagcttca 1321 gcttctcctc caatgtgctc tcctaggcca cagggccttt ggcaggtgca gcccccactg 1381 cctttgacct gcctcccztc atgcatggaa attcccttca tctggaacca tcagaaacac 1441 cctcacactg ggacttgcaa aaagggtcag tatgggttag ggaaaacatt ccatccttga 1501 gtcaaaaaat ctcaattctt ccctatcttt gccaccctca tgctgtgtga ctcaaaccaa 1561 atcactgaac tttgctgagc ctgtaaaata aaaggtcgga ccagcttttc ccaaaagccc 1621 attcattcca ttctggaagt gactttggct gcatgcgagt gctcatttca ggat 1 aattcagagc caccgcgggc aggcgggcag tgcatccaga agcgtttata ttctgagcgc 61 cagttcagct ttcaaaaaga gtgctgccca taaaaagcct tccaccctcc tgtctgcttt 121 agaaggaccc tgagccccag gcgccagcca caggactctg ctgcagaggg gggttgtgta 181 cagatagtag gctttacgcc tagcttcgaa atggataacg tcctcccggt ggactcagac 241 ctctccccaa acatctccac taacacctcg gaacccaatc agttcgtgca accagcctgg 301 caaattgtcc tttgggcagc tgcctacacg gtcattgtgg tgacctctgt ggtgggcaac 361 gtggtagtga tgtggatcat cttagcccac aaaagaatga ggacagtgac gaactatttt 421 ctggtgaacc tggccttcgc ggaggcctcc atggctgcat tcaatacagt ggtgaacttc 481 acctatgctg tccacaacga atggtactac ggcctgttct actgcaagtt ccacaacttc 541 tttcccatcg ccgctgtctt cgccagtatc tactccatga cggctgtggc ctttgatagg 601 tacatggcca tcatacatcc cctccagccc cggctgtcag ccacagccac caaagtggtc 661 atctgtgtca tctgggtcct ggctctcctg ctggccttcc cccagggcta ctactcaacc 721 acagagacca tgcccagcag agtcgtgtgc atgatcgaat ggccagagca tccgaacaag 781 atttatgaga aagtgtacca catctgtgtg actgtgctga tctacttcct ccccctgctg 841 gtgattggct atgcatacac cgtagtggga atcacactat gggccagtga gatccccggg 901 gactcctctg accgctacca cgagcaagtc tctgccaagc gcaaggtggt caaaatgatg 961 attgtcgtgg tgtgcacctt cgccatctgc tggctgccct tccacatctt cttcctcctg 1021 ccctacatca acccagatct ctacctgaag aagtttatcc agcaggtcta cctggccatc 1081 atgtggcigg ccatgagctc caccatgtac aaccccatca tctactgctg cctcaatgac 1141 aggttccgtc tgggcttcaa gcatgccttc cggtgctgcc ccttcatcag cgccggcgac 1201 tatgaggggc tggaaatgaa atccacccgg tatctccaga cccagggcag tgtgtacaaa 1261 gtcagccgcc tggagaccac catctccaca gtggtggggg cccacgagga ggagccagag 1321 gacggcccca aggccacacc ctcgtccctg gacctgacct ccaactgctc ttcacgaagt 1381 gactccaaga ccatgacaqa gagcttcagc ttctcctcca atgtgctctc ctaggccaca 1441 gggcctttgg caggtgcagc ccccactgcc tttgacctgc ctcccttcat gcatggaaat 1501 tcccttcatc tggaaccatc agaaacaccc tcacactggg acttgcaaaa agggtcagta 1561 tgggttaggg aaaacactcc atccttgagt caaaaaatct caattcttcc ctatctttgc 1621 caccctcatg ctgtgtgact caaaccaaat cactgaactt tgctgagcct gtaaaataaa 1681 aggtcggacc agcttttcct caagagccca atgcattcca tttctggaag tgactttggc 1741 tgcatgcgag tgctcatttc aggatg 1 gaaaaagcct tccaccctcc tgtctggctt tagaaggacc ctgagcccca ggcgccacga 61 caggactctg ctgcagaggg gggttgtgta cagatagtag ggctttaccg cctagcttcg 121 aaatggataa cgtcctcccg gtggactcag acctctcccc aaacatctcc actaacacct 181 cggaacccaa tcagttcgtg caaccagcct ggcaaattgt cctttgggca gctgcctaca 241 cggtcattgt ggtgacctct gtggtgggca acgtggtagt gatgtggatc atcttagccc 301 acaaaagaat gaggacagtg acgaactatt ttctggtgaa cctggccttc gcggaggcct 361 ccatggctgc attcaataca gtggtgaact tcacctatgc tgtccacaac gaatggtact 421 acggcctgtt ctactgcaag ttccacaact tcttccccat cgccgctgtc ttcgccagta 481 tctactccat gacggctgtg gcctttgata ggtacatggc catcatacat cccctccagc 541 cccggctgtc agccacagcc accaaagtgg tcatctgtgt catctgggtc ctggctctcc 601 tgctggcctt cccccagggc tactactcaa ccacagagac catgcccagc agagtcgtgt 661' gcatgatcga atggccagag catccgaaca agatttatga gaaagtgtac cacatctgtg 721 tgactgtgct gatctacttc ctccccctgc tggtgattgg ctatgcatac accgtagtgg 781 gaatcacact atgggccagt gagatccccg gggactcctc tgaccgctac cacgagcaag 841 tctctgccaa gcgcaaggtg gtcaaaatga tgattgtcgt ggtgtgcacc ttcgccatct 901 gctggctgcc cttccacatc ttcttcctcc tgccctacat caacccagat ctctacctga 961 agaagtttat ccagcaggtc tacctggcca tcatgtggct ggccatgagc tccaccatgt 1021 acaaccccat catctactgc tgcctcaatg acaggtgagg atcccaaccc catgagctct 1081 ccaggggcca caagaccatc tacatacaca gtggccaagc ggcarcctaa atgagtaaac 1141 ccagctgtga gacaagaggg acaagtgggg actgcagcta acttatcatc acacaactca WO 00/09525 PCT/US99/17712 EPI-109 803 1201 gcctggctga ttatcaccat ccaggaatgg gagcccggag tagaczgatt ttcttttttt 1261 cttttcca 1 atgctgagaa aggtagctgc caaaccttga ctgcaataac aataacaaaa attaaaaacc 61 taaaataata agtatatcat actgaccttt cctgtttacc ttgctgtagg taccacatct 121 gtgtgactgt gctgatctac ttcctccccc tgctggtgat tggctatgca tacaccgtag 181 tgggaatcac actatgggcc agtgagatcc ccggggactc ctctgaccgc taccacgagc 241 aagtctctgc caagcgcaag gtgagcaggg gacaggcaga actaacccac cctggcacag 301 acaacaggct gtcgagaagg gatggcacac ttgtgagccc cagaggcagc tagcacaaaa 361 tatccccagg tat 1 ggatccaatt tttgcccggc ataagtgtat agtaaatttc ccagccttaa agcacttccc 61 gagagatgct ttgagcgctc gcggtaccag tgcgtaaacg ccgctccccg gctggcgcgg 121 gtgtgcgcca actccaacct gcgcgcaagt ctgccggtgc gcgctccagt cccacagctc 181 cgagtccccg cagtgaaagg agggggcggt gcaccggggt agatgggccc ctgaggactc 241 ccggggttca gttttccgcg gctgccaaga gggccaagtt ggacagtggc agggtcctga 301 agcagatcag caacaaccgc aagtgctcca gccccaggtc ctcagacacg gaggaaaacg 361 acaagaggcg gacacacaac gtcttggaac gtcagaggag gaacgagctg aagcgcagct 421 tttttgccct gcgtgaccag atccctgaat tggaaaacaa cgaaaaggcc cccaaggtag 481 tgatcctcaa aaaagccacc gcctacatcc tgtccattca agcagacgag cacaagctca 541 cctctgaaaa ggacttattg aggaaacgac gagaacagtt gaaacacaaa ctcgaacagc 601 ttcgaaactc tggtgcataa actgacctaa ctcgaggagg agctggaatc tctcgtgaga 661 gtaaggagaa cggttccttc tgacagaact gatgcgctgg aattaaaatg catgctcaaa 721 gcctaacctc acaaccttg4 ctggggcttt gggactgtaa gcttagagac tgtcacttcc 781 caggtgaatc agctagccag gtaactgagc tagatatttt gtgggggtgt ttcctaaaca 841 cagcctcagg aaagttgttt tcgggacacc tggaccaggg agtcgtcgcc tctggcttct 901 cggtagctgg agcgcggccc ggagcgcggc gctggcacat cgcccccaca catgaccgtt 961 tcccattgcc acaggcaagc cgcctctgca gagctgtctc agggctctgg gcttcattcc 1021 ctggaagttg attgtcctcc actccagctg tttcccaaat ccttccttcc tcccagcacc 1081 cctcgtgcaa cgacgattcc agctgcggac cgcatctgtg tcagttactt ccaagccacc 1141 tactgccccc tcgcggagtg cgtggggctc ccggctcgca gactcccacg gcaagtagca 1201 agcagcaaaa ggcgtggtag ctgcggcggt ggaatgagac agttgtcaac agctggcgca 1261 cgtgccgccg tgcgcaccgg gactggcgag tacgcagccc aggtactgcc ccttcccagt 1321 gacgtctctg cagggggtta taaaagcctc gtgcgcagct aactcgcgag ctgagcaacc 1381 cgaaccgaga ggtgcccgcg aaactgcagg cggcggcagc ggcagcaaaa gagaaggaaa 1441 aatctccagc tggatacgaa gctccagaat cctggccata ggctcagaac ttttacaggt 1501 cgcgctgcaa tgggccccca cttcgctcct aagtcctcac gcagcacagg gctttgcctt 1561 tccctgcgga ggaaggagaa ataggagttg caggcagcag caggtgcata aatgcggggg 1621 atctcttgct tcctagaact gtgaccggtg gaatttcttt ccctttttca gtttaccgca 1681 agagagatgc tgtctccaga cttctgaact caaacgtctc ctgaagcttg aaagtggagg 1741 aattcagagc caccgcgggc aggcgggcag tgcatccaga agcgtttata ttctgagcgc 1801 cagttcagct ttcaaaaaga gtgctgccca gaaaaagcct tccaccctcc tgtctggctt 1861 tagaaggacc ctgagcccca ggcgccagcc acaggactct gctgcagagg ggggttgtgt 1921 acagatagta gggctttacc gcctagcttc gaaatggata acgtcctccc ggtggactca 1981 gacctctccc caaacatctc cactaacacc tcggaaccca atcagttcgt gcaaccagcc 2041 tggcaaattg tcctttgggc agctgcctac acggtcattg tggtgacctc tgtggtgggc 2101 aacgtggtag tgatgtggat catcttagcc cacaaaagaa tgaggacagt gacgaactat 2161 tttctggtga acctggcctt cgcggaggcc tccatggctg cattcaatac agtggtgaac 2221 ttcacctatg ctgtccacaa cgaatggtac tacggcctgt tctactgcaa gttccacaac 2281 ttcttcccca tcgccgctgt cttcgccagt atctactcca tgacggctgt ggcctttgat 2341 aggtgagatt agcctttgtg aaaaggcgag aaagtgctca tagaggacca tggcattgct 2401 gtgaggtttg gaactgggtg gggtatgggt caagtggaag attggccact ctgagggttt 2461 ttttactgat ca 1 agaatatgga aaaggaattg gaaaataatt gtacaaatca tcaggaatca aagggtttct 61 atgaattttc ttattggcag gaaaaatatg gaatctctga tacagatttt ggtgaccaga 121 tcagaacttt gttctttctt ctctgttcca ggtacatggc catcatacat cccctccagc 181 cccggctgtc agccacagcc accaaagtgg tcatctgtgt catctgggtc ctggctctcc 241 tgctggcctt cccccagggc tactactcaa coacagagac catgcccagc agagtcgtgt 301 gcatgatcga atggccagag catccgaaca agatttatga gaaagtgtga gtagagatga 361 ctccccatgc caaagaaacg atggtgcagg ctgccttcct ggccccttct tgctctttct 421 ttctttccat attcttttgt tggtacagat ttaatgtgta tctgcaagca tttctcacat 481 ataccctcat atcaggttga tatgtccaca gttgtcaggg gactatagta tcccaaatac 541 tattctgagc attgaaagat aatttttgaa gtgtaagatc tagatcctgt tata 1 gagggggatg tgctggtggt ctcacctgtc tcaccctctt gccaggtggt caaaatgatg 61 attgtcgtgg tgtgcacctt cgccatctgc tggctgccct tccacatctt cttcctcctg 121 ccctacatca acccagatct ctacctgaag aagtttatcc agcaggtcta cctggccatc 181 atgtggctgg ccatgagctc caccatgtac aaccccatca tctactgctg cctcaatgac 241 aggtgaggat cccaacccca tgagctctcc aggggccaca agaccatcta catacacagt 301 ggccaagcgg catctaaatg agtaaaccca gctgtgagac aagagggaca agtggggact 361 gcagctaact t WO 00/09525 PCT/US99/17712 EPI-109 804 1 ccgtcccaaa ggtcacctct tcatctgctc gctctccagg ttccgtctgg gcttcaagca 61 tgccttccgg tgctgcccct tcatcagcgc cggcgactat gaggggctgg aaatgaaatc 121 cacccggtat ctccagaccc agggcagtgt gtacaaagtc agccgcctgg agaccaccat 181 ctccacagtg gtgggggccc acgaggagga gccagaggac ggccccaagg ccacaccctc 241 gtccctggac ctgacctcca actgctcttc acgaagtgac tccaagacca tgacagagag 301 cttcagcttc tcctccaatg tgctctccta ggccacaggg cctttggcag gtgcagcccc 361 cactgccttt gacctgcctc ccttcatgca tggaaattcc cttcatctgg aaccatcaga 421 aacaccctca cactgggact tgcaaaaagg gtcagtatgg gttagggaaa acattccatc 481 cttgagtcaa aaaatctcaa ttcttcccta tctttgccac cctcatgctg tgtgactcaa 541 accaaatcac tgaactttgc tgagcctgta aaataaaagg tcggaccagc ttttcccaaa 601 agcccattca ttccattctg gaagtgactt tggctgcatg cgagtgctca tttcaggatg 661 aattctgcag cacagctgcg gacccggaag actcattttc ctggagcccc gtgttacttc 721 aataaagtta tctcagatta gcctcctgca gctggaggct cctatcaccc cagcctacgc 781 ttgacagggt gaacaaaaga aggcaccaca taacatctaa atgaaaaatt tagccctgtc 841 ttctaagcat ctgtgaaaag aaacatatgt attccccttt ttggcatctc agtatttcag 901 tacatttata catcatgaga ttgagaacct cgggcttcca cattatgtcc ccggtgactg 961 tcctgagcag ccgacgcaag cagaatatgt ccactgatac ctgctagttc tcttacagac 1021 caggaattgg gagacttgca ctacatttaa tgtgtagttg accctctttt cctacttgta 1081 aacaagggga ctgaactaga taatctaagt gttccttcga atcttaacat cccgtggttc 1141 aaggattgta tgagtttttt gtttgtttta caaaaaaaaa caaaacgaag aataaaagaa 1201 tagaaaagaa taggagcagt gagtcttgta actaataccc agttcctgga gatgtagcaa 1261 ctgctaaggc catctgtaac tatccatctc agacattctc cgatttatct taaaatcctq 1321 agtacattcc ttctcatgga aggttttggc ttttgacaga gcagaggact tcatgccaag 1381 gcctgcatcc atccagcttt agcaggcaga atttcatagc tgcagaacac tgtcagagaa 1441 gacaaatgtg ggctccctgc tttaaccttt tgggtatttt agggtggggg ccctaacctt 1501 cattcttagt tttacactag catcgtgctc atatgtgcga caagcaagaa ggctgcactt 1561 tgcagctgca cttctgggaa gagggcatct tgcatcttcc cttcagactc tctgaatgtc 1621 tcctccctgc tccatggctt tgccagcttc ctgtctctaa ggggtagaat gactcatcaa 1681 ccctaaagga cagtcagtct tccaagagcc atgaactgaa tgctttatat cctaatttag 1741 atttagagtt tccagaaggt gagcatgcag ttttgttttg tttttttttc tgtctcccaa 1801 atctgtgttt tttccagata tggctggaag cagaagcttc atgtaacatc catgaatgtc 1861 ctcctggtag tttgcataat ggatgcacat gtgccgcatc cataacatta aggggagaat 1921 aatgcatggt ttacagcctt tgccagccct gctggctcta attctaccag ggcatccaca 1981 ggcctggggg aagaagaaac agtataagcc agaaaacctc aagaactaca ttctctaaag 2041 cagcatggaa agttttaaat aaactaagtg aagccagatc attgcagata tataaatgga 2101 agacaaaatt tagaagcaac aaaagttagt gccctaagca ttagtcatac ttccaataga 2161 gaatcttgct gtgtatggat tactcacttt ggaagaatgt aaagagctaa catgattatg 2221 agaagtacct gagaagatgg tgtcaagaag ttggggacac cccatctatg gaagagaagg 2281 ttagagttga gctcaacgag gattaactga gtgcctcctc tggactttgc cctgaactgg 2341 gaacacacag cccctgcagc tcttgaagag cctaccttat tggccatcac taactaactc 2401 accagtccta gtgagtctaa gctgcccagc agtcttggag gcatctgaga ggacagattc 2461 tccacagaat tctaaaaacc cacactcaac atgggcagtc aagcaaagac tgggaccttt 2521 ggagagcctc tggaatgaga gttctctggg gtacttccaa agggagctgg cagtcagtcc 2581 aggggaccta aaggaatttg gttgaacagt atcatctctg tgcatagtaa gagggaatgt 2641 tgggtggtcc gggcagtttc caatatggca aagcatctgc ttggacagtg ccagcaagcc 2701 ttcctctgac ccagtctcca atgtccacta acttataaaa atgtcatcaa ctcccacatg 2761 tgagaaacac catgatttgt actgtgcatg ggtcacattc ttattctaga aatgcatcac 2821 cctgtgttta tccaagtgtg tttacttggt gtaatgtcca gtagtaatag aatatgaaat 2881 atcaaggaac catctttgtt acgtgacttc caaaatgtga gatctcattg ctgtcactgt 2941 gatatttgta ttgtgtgaat ctcttcctcc tcttcctcct catgctttct cagggaggag 3001 ccctgatgta tatcatgaac tcacagttcc tagaccacag taattgaggg gcggtggggg 3061 ggcctttatc ggagaagcta gagaacaaga gtccttctcc tccttatccc ccaacaggac 3121 actaagagac aaggactgag tggaatcctg gagaaagggg actcaggaac tgacctcatt 3181 ggcctgattt gtgaggagag gagtataagt ggagaggggc cattcctgag gtttccgtgt 3241 tttccagcct ggtctcctgg aaagaatctt tatacagaaa taaagtatgt gtttcactct 3301 ctcgtgcctc tgtctcttct ctaggggtcc taaacatcct ataggatgct aaatgggatg 3361 gtactagaaa ccctaataac ttgcatagct agaaggatgg aatcaatgtt cagtaaactc 3421 ttgactctgt gatgaaatgg gttgggaaga tgtgggaaca gttcccaggt tgagatctgg 3481 gaagggaggt gggattatgc gaaatcacag tgatgttgcc tatgaataaa gctgtgtcag 3541 gatgcagaca caacagagtt ataagcacaa gggagttttc gtaggacagg aggttggggg 3601 gaataacatc tgagaaagac aaaggggaaa gaaagcagaa gtactcaggg acagccttca 3661 gaccaccatg ccaatctgac acctgggaaa aaaggggtgg ttaggaagag cctcagactg 3721 tggtgcagct cccagcccaa cacgtgcaaa gattgcccag agagacattg cacgttaaca 3781 gaatggccag gcctgatgcc ctgccgtgct cagccgctgg ctggggctct ctagggaaag 3841 tgttctgtgt ttgaacacca tggtggatgc tgaagccctg cagctggagg ctgtcagcca 3901 agtgccctgc agttcttcct aaagaggga (2) INFORMATION FOR SEQ ID NO:2641: WO 00/09525 PCT/US99/17712 EPI-109 805 (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2641 1 gggtctcaag gaatctttat tctgcgtctt cattctgaac tggatggaac cttcctgagc 61 gcagagtcct ttccactgtg aattatgggt ttgttatcgt ttttgttcgt tgctggttgt 121 acgtgacggg agttcagctt tttgctgcgg gacggcagag ataggatgcg gggcttcctg 181 agaggcgccg gggcagggcc gcacaggtcc atccacctcc cctgggaccc cagccctgca 241 gcagccccag gggagcggcc ggggatcggg gcggggtgcc caggacgcgc cctgattggc 301 ccagtgttag ccaatcaagg ctctcgcatc cccatggtgc tgattggtcc gcctcccagg 361 cctgacccaa tcggagcatt cctaggagga gcggccccag agcgcctgac tcgggggtcc 421 cagagccctc tgcacaccac agccccggtg tccccgtgtg tccctgggtt ctcccagccc 481 tggtgtcccc tgagtctctt cttcaccgtc agccctggtg tctcccgtgt ccctgccaca 541 ccctcatccc tggtgtcccc cgtcacccca tcccctcacc tcctgggctc ctgaaggtcc 601 catcttgtgg gcctcattca tggaaccagg acggggcagg tggaggcctc tggggagttt 661 gtccagagaa tggaggagaa gcagggtcat gagcaggagc ggtctgggcc acccctgcct 721 gtcccccggg gggtgcagcc cggaaggagt ccagatggat atggccccgc agtgcagagt 781 cagccccaaa ccaggctggt cccaggcagg gtgggggcag gaggagcccc ggagtggccc 841 tgtgttgggg gtcggggggc aggcaggggg tcctggggct cagaagcgga ggaggtgggc 901 tggaggcccc agtgaccaac aggcccacgg gagtcgggag gtggggtgga cggacctgca 961 gggacagtgt cagcgctgaa tgggatggag agcacaggga gctggggccg gggatgagac 1021 catggggagc tggggctggg gctgggacta gtccatgggg agctggggct gaagttgggg 1081 gtgagtccat ggggagctgg gctgggcctc ctggggttgc acctgcactc ctctctgctc 1141 ttccctctgc gtatgaagct cagatoccat gataaggagg cacctgcaga ccaggggacc 1201 tgcacggaca gccccagagg tggacattga ggactcgtag gaggacttgg gtctcatacg 1261 gcgggtgggg agcagggccc cttcctggct gaggacactt ggtgctgtcc cctctcaagg 1321 ctgtttcccc atctgacaaa ggggtctcat gtgagccccc aaccaagtga gtcgaggagg 1381 gctggcccca cccccgtgga tttggagtcc gtaggagggg tgtcacccgt cacgtcccca 1441 ccccgtgggc accttcccgt ctcttggagc gtggcccatg gacatgagtt cctcacccgt 1501 gtccctcttg gggaaacagg tttcaggagc gacgggtctt gtagcctggg gcagccaggc 1561 cacctgggtg cagctatgcc tgaaggcctc ctggcaccga gacaggggca ggagcagatc 1621 ccaccagcgg gaaggtggtg cgttctgatg ctgggatcca ccagctgaca ggtggagctg 1681 cgagcctcca gtgctcagcc ctcggcgggg cctgcctggc agccccacac acagagggca 1741 tcggggtggc gggggcacgt gttacacggg ggccctgggt ctgagtcatc cacttcctcc 1801 gagtctggat gggaggaccc agcgcccctc ctccgccccc tcctgatctg gaaggataaa 1861 tggggagggg agagcccgct gggtagaagg aacagggagt ggccagggta agtccctact 1921 ctcagagacc ctgacatcag tgtcacctgg agcagagtgg cccagcctca gactcagagc 1981 accaagaccc aggcccgcag gcctggaccc accccggtcc ccccgtccca gctccattct 2041 tcaccccaca atctgtagcc cccagccctg ccctgtgagg cccggccagg cccacgatgc 2101 tcctccttgc tccccagatg ctgagcctgc tgctgctggc gctgcccgtc ctggcgagcc 2161 cggcctacgc ggcccctggt gagtcccagc cggggtccac cctgcccctc accacattcc 2221 acaggtcagg gcctgggtgg gttctgggga ggctgggctg gcccccacac agggaagggc 2281 tgggcccagg cgtggggctg cttcctggtc ctgacctggc acctgcccca gccccagtcc 2341 aggccctgca gcaagcgggt atcgtcgggg gtcaggaggc ccccaggagc aagtggccct 2401 ggcaggtgag cctgagagtc cgcgaccgat actggatgca cttctgtggg ggctccctca 2461 tccaccccca gtgggtgctg accgcggcgc actgcctggg accgtgagtc tcccagggcc 2521 tggaggggtg ggcaagggct ggatgtgagc cctggctccc gggtgctcct gggggctgcc 2581 cagggccctg agtgggatcc tccgctgccc agggacgtca aggatctggc caccctcagg 2641 gtgcaactgc gggagcagca cctctactac caggaccagc tgctgccggt cagcaggatc 2701 atcgtgcacc cacagttcta catcatccag actggagcgg atatcgccct gctggagctg 2761 gaggagcccg tgaacatctc cagccgcgtc cacacggtca tgctgccccc tgcctcggag 2821 accttccccc cggggatgcc gtgctgggtc actggctggg gcgatgtgga caatgatggt 2881 gggtctgggg acagtgggag gtggggccag ggtcttagcc acagcccagc ccctgggctc 2941 caggtggggg ttgcccggcc ccctcctcag gctgcaccct cttccccacc tgcagagccc 3001 ctcccaccgc catttcccct gaagcaggtg aaggtcccca taatggaaaa ccacatttgt 3061 gacgcaaaat accaccttgg cgcctacacg ggagacgacg tccgcatcat ccgtgacgac 3121 atgctgtgtg ccgggaacac ccggagggac tcatgccagg tgggccccgc gtgtcccccg 3181 ccccccgcac cccaaccccc actcccaggc ctgttcggcg agcgctgacc tctgaccttc 3241 ccagggcgac tctggagggc ccctggtgtg caaggtgaat ggcacctggc tacaggcggg 3301 cgtggtcagc tgggacgagg gctgtgccca gcccaaccgg cctggcatct acacccgtgt 3361 cacctactac ttggactgga tccaccacta tgtccccaaa aagccgtgag tcaggcctgg 3421 ggtgtccacc tgggtcactg gagagccagc ccctcctgtc caaaacacca ctgcttccta 3481 cccaggtggc gactgccccc cacaccttcc ctgccccgtc ctgagtgccc cttcctgtcc 3541 taagccccct gctctcttct gagccccttc ccctgtcctg aggacccttc cccatcctga 3601 gcccccttcc ctgtcctaag cctgacgcct gcactgggcc ctccggccct cccctgccca 3661 ggcagctggt ggtgggcgct aatcctcctg agtgctggac ctcattaaag tgcatggaaa 3721 tcactggtgt gcatcgctgt gtttctggtt gtggatgtca ctgggagaga aggggtccag WO 00/09525 PCT/US99/17712 EPI-109 806 3781 gtgtgctgag gacacct-cc acagtgcgag gtcctagccc tcaaggcaca gccagtcacc 3841 gtgggacggg gcctcctagg cagccctggt ccccggggct ggcttctccc cacacgatgc 3901 atccagcatt cgggtcacac agagccactc gggcaactca gttgattata aaggacagcc 3961 aagtccctgc aaccgggtca agacagagaa tggtcgccgg gagccccagg gctgcccatc 4021 acgagcccct accccacgct tcccacgagc tcttctcccg gcccctctgt ccactgcttg 4081 tgctttgccc tagttgtttg ctttgagaca ggatctcgct gtgtcatcca ggctgaagtg 4141 cagtggtgtg atcagggctc actgtagcct tgaactcctg ggctcaagcg atcctcccat 4201 cttggcctcc catatagctg ggccacagga gtgagccacc acgcccagtt aatttttgta 4261 ttttcagtag agatggggtt tcgccatgtt ggccagtctg gtctcgaact cctgacctca 4321 agtgatctgc ccgcctcagc ctcccaaagt gctgggatga caggcgtgag ccaccgcacc 4381 cagcctgagt ttgacatttt caaattcatt ttgaggtctt tctctacatc aatacatgag 4441 ccctccgcgt ccggcgautg ttgcatttta tcccgggctc ttgtttgcat tttatatttg 4501 aacatgatta cattcaggaa tgaaatgcgg ggctgttctg gttgaaaaca actctctaaa 4561 gaaacattca ctctttcctt ccaactgtca gatgcagaga tgtgcattta gtctctccaa 4621 tctctgcaaa tgacctctgt cctcacaagg ggtggactcg acttccagcg ccctctccag 4681 ccccacgtga cctctgcczc tgcagcccct gaaggcccat ccctcggctc ctgttctgca 4741 ggcccagcgt cttgtctatg aagatggacc tggaactcgg gccctccttc ctccctctgg 4801 cccatcccac cttctaggga tcacagagac agcacggggt gacccccagg gaacactgag 4861 cccctagaag cacttccaca cgcccactgg aggttttgcg gggtgggagt cggagggatg 4921 agaccccgaa gggaagcaag acggcccctc aggacagggc tgccggtgta aggaaaggtg 4981 gacagcaggg gccggtcact gggtggaggg ggagggcagg ctccagcccc agagcttccc 5041 aaattagatc taagatccct gggaagctca gtgaagctca gcgcagtgac actggcagat 5101 gtgagcgtca gcttcagcag gaagggtctc tcaggacgtg acaggcaggc tgctggccag 5161 ggctgcagcc acctgcgttt tgactgggac gggggcacct gatccaaggt cacccacgtg 5221 gctgccggca ggaggccctg gttccccgtc acaagggggt gtgaggggga aggccaagtg 5281 gtggccacan ggttnccacc gagagggaca gtgcccaagt tggccaagcc accctnggac 5341 aagaaacaat nccaagtctt nccaaggtcc ttggacaaca aggagaancc cccccagctt 5401 gggggcnatt aaccaagggc cangnccccc cttcccggtt c (2) INFORMATION FOR SEQ ID NO:2642: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: _base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2642 1 tggacccacc ccggtccccc cgtcccagct tccattcttc accccacaat ctgtagcccc 61 cagccctgcc ctgtgaggcc cggccaggcc cacgatgctc ctccttgctc cccagatgct 121 gaatctgctg ctgctggcgc tgcccgtcct ggcgagccgc gcctacgcgg cccctggtga 181 gtcccagccg gggtccaccc tgcccctcac cacattccac aggtcagggc ctgggtgggt 241 tctggggagg ccgggctggc ccccacacag ggaagggctg ggcccaggcc tggggctgct 301 tcctggtcct gacctggcac ctgccccagc cccaggccag gccctgcagc gagtgggcat 361 cgttgggggt caggaggccc ccaggagc (2) INFORMATION FOR SEQ ID NO:2643: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: _base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear )xi)SEQUENCE DESCRIPTION: SEQ ID NO:2643 1 cagatcggag cggacatcgc cctgctggag ctggaggagc cggtgaaggt ctccagccac 61 gtccacacgg tcaccctgcc ccctgcctca gagaccttcc ccccggggat gccgtgctgg 121 gtcactggct ggggcgatgt ggacaatgat ggtgggtctg gggacagtgg aggtggggcc 181 agggtcttag ccacagccca gcccctgggc tccctctggg ctccaggtgg gggttgcccg 241 gccccctcct gaggctgcac cctcttcccc acctgcagag cgcctcccac cgccatttcc 301 tctgaagcag gtgaaggtcc ccataatgga aaaccacatt tgtgacgcaa aataccacct 361 tggcgcctac acgggagacg acgtccgcat cgtccgtgac gacatgctgt gtgccgggaa 421 cacccggagg gactcatgcc aggtgggccc cgcgtgtccc ccgccccccg caccccaacc 481 cccactccca ggcctgttcg gcgagcgctg acctctgacc ttcccagggc gactccggag 541 ggcccctggt gtgcaaggtg aatggcacct ggctgcaggc gggcgtggtc agctggggcg 601 agggctgtgc ccagcccaac cggcctggca tctacacccg tgtcacctac tacttggact 661 ggatccacca ctatgtcccc aaaaagccgt gagtcaggcc tgggttggcc acctgggtca 721 ctggaggacc aacccctgct gtccaaaaca ccactgcttc ctacccaggt ggcgactgcc 781 ccccacacct tccctgcccc gtcctgagtg ccccttcctg tcctaagccc cctgctctct 841 tctgagcccc ttcccctgtc ctgaggaccc ttccccatcc tgagccccct tccctgtcct 901 aagcctgacg cctgcactgg gccctccggc cctcccctgc ccaggcagct ggtggtgggc 961 gctaatcctc ctgagtgctg gacctcatta aagtgcatgg aaatcactgg tgtgcatcgc 1021 tgtgtttctg gttgtggatg tcactgggag agaaggggc caggtgtgct gaggacacct WO 00/09525 PCTIUS99/17712 EPI-109 807 1081 gccacagtgt gaggtcctag ccctcaaggc acaagccagt caccgtggga cggggcctct 1141 gggcagccct ggtccccgag ctggctt (2) INFORMATION FOR SEQ ID NO:2644: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2644 1 ccaggatgct gaatctgctg ctgctggcgc tgcccgtcct ggcgagccgc gcctacgcgg 61 cccctgcccc aggccaggcc ctgcagcgag tgggcatcgt tgggggtcag gaggccccca 121 ggagcaagtg gccctggcag gtgagcctga gagtccacgg cccatactgg atgcacttct 181 gcgggggctc cctcatccac ccccagtggg tgctgaccgc agcgcactgc gtgggaccgg 241 acgtcaagga tctggccgcc ctcagggtgc aactgcggga gcagcacctc tactaccagg 301 accagctgct gccggtcagc aggatcatcg tgcacccaca gttctacacc gcccagatcg 361 gagcggacat cgccctgctg gagctggagg agccggtgaa ggtctccagc cacgtccaca 421 cggtcaccct gccccctgcc tcagagacct tccccccggg gatgccgtgc tgggtcactg 481 gc'tggggcga tgtggacaat gatgagcgcc tcccaccgcc atttcctctg aagcaggtga 541 aggtccccat aatggaaaac cacatttgtg acgcaaaata ccaccttggc gcctacacgg 601 gagacgacgt ccgcatcgtc cgtgacgaca tgctgtgtgc cgggaacacc cggagggact 661 catgccaggg cgactccgga gggcccctgg tgtgcaaggt gaatggcacc tggctgcagg 721 cgggcgtggt cagctggggc gagggctgtg cccagcccaa ccggcctggc atctacaccc 781 gtgtcaccta ctacttggac tggatccacc actatgtccc caaaaagccg tgagtcaggc 841 ctgggtgtgc cacctgggtc actggaggac caacccctgc tgtccaaaac accactgctt 901 cctacccagg tggcgactgc cccccacacc ttccctgccc cgtcctgagt gccccttcct 961 gtcctaagcc ccctgctctc ttctgagccc cttcccctgt cctgaggacc cttccccatc 1021 ctgagccccc ttccctgtcc taagcctgac gcctgcactg ctccggccct cccctgccca 1081 ggcagctggt ggtgggcgct aatcctcctg agtgctggac ctcattaaag tgcatggaaa 1141 tca (2) INFORMATION FOR SEQ ID NO:2645: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: _base pairs (H) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2645 1 ggccaggatg ctgaatctgc tgctgctggc gctgcccgtc ctggcgagcc gcgcctacgc 61 ggcccctgcc ccaggccagg ccctgcagcg agtgggcatc gttgggggtc aggaggcccc 121 caggagcaag tggccctggc aggtgagcct gagagtccac ggcccatact ggatgcactt 181 ctgcgggggc tccctcatcc acccccagtg ggtgctgacc gcagcgcact gcgtgggacc 241 ggacgtcaag gatctggccg ccctcagggt gcaactqcgg gagcagcacc tctactacca 301 ggaccagctg ctgccggtca gcaggatcat cgtgcaccca cagttctaca ccgcccagat 361 cggagcggac atcgccctgc tggagctgga ggagccggtg aaggtctcca gccacgtcca 421 cacggtcacc ctgccccctg cctcagagac cttccccccg gggatgccgt gctgggtcac 481 tggctggggc gatgtggaca.atgatgagcg cctcccaccg ccatttcctc tgaagcaggt 541 gaaggtcccc ataatggaaa accacatttg tgacgcaaaa taccaccttg gcgcctacac 601 gggagacgac gtccgcatcg tccgtgacga catgctgtgt gccgggaaca cccggaggga 661 ctcatgccag ggcgactccg gagggcccct ggtgtgcaag gtgaatggca cctggctgca 721 ggcgggcgtg gtcagctggg gcgagggctg tgcccagccc aaccggcctg gcatctacac 781 ccgtgtcacc tactacttgg actggatcca ccactatgtc cccaaaaagc cgtgagtcag 841 gcctgggttg gccacctggg tcactggagg accaacccct gctgtccaaa acaccactgc 901 ttcctaccca ggtggcgact gccccccaca ccttccctgc cccgtcctga gtgccccttc 961 ctgtcctaag ccccctgctc tcttctgagc cccttcccct gtcctgagga cccttcccca 1021 tcctgagccc ccttccctgt cctaagcctg acgcctgcac cgggccctcc ggccctcccc 1081 tgcccaggca gctggtggtg ggcgctaatc ctcctgagtg ctggacctca ttaaagtgca 1141 tggaa (2) INFORMATION FOR SEQ ID NO:2646: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2646 1 tgaatctgct gctgctggcg ctgcccgtcc tggcgagccg cgcctacgcg gcccctgccc 61 caggccaggc cctgcagcga gtgggcatcg tcgggggtca ggaggccccc aggagcaagt 121 ggccctggca ggtgagcctg agagtccacg gcccatactg gatgcacttc tgcgggggct 181 ccctcatcca cccccagtgg gtgctgaccg cagcgcactg cgtgggaccg gacgtcaagg WO 00/09525 PCT/US99/17712 EPI-109 808 241 atctggccgc cctcagggtg caactgcggg agcagcacct ctactaccag gaccagctgc 301 tgccggtcag caggatcatc gtgcacccac agttctacac cgcccagatc ggagcggaca 361 tcgccctgct ggagctggag gagccggtga acgtctccag ccacgtccac acggtcaccc 421 tgccccctgc ctcagagacc ttccccccgg ggatgccgtg ctgggtcact ggctggggcg 481 atgtggacaa tgatgagcgc ctcccaccgc catttcctct gaagcaggtg aaggtcccca 541 taatggaaaa ccacatttgt gacgcaaaat accaccttgg cgcctacacg ggagacgacg 601 tccgcatcgt ccgtgacgac atgctgtgtg ccgggaacac ccggagggac tcatgccagg 661 gcgactccgg agggcccctg gtgtgcaagg tgaatggcac ctggctgcag gcgggcgtgg 721 tcagctgggg cgagggctgt gcccagccca accggcctgg catctacacc cgtgtcacct 781 actacttgga ctggatccac cactatgtcc ccaaaaagcc gtgagtcagg cctgggttgg 841 ccacctgggt cactggagga ccaacccctg ctgtccaaaa caccactgct tcctacccag 901 gtggcgactg ccccccacac cttccctgcc ccgtcctgag tgccccttcc tgtcctaagc 961 cccctgctct cttctgagcc ccttcccctg tcctgaggac ccttccctat cctgagcccc 1021 cttccctgtc ctaagcctga cgcctgcacc gggccctcca gccctcccct gcccagatag 1081 ctggtggtgg gcgctaatcc tcctgagtgc tggacctcat taaagtgcat ggaaatc (2) INFORMATION FOR SEQ ID NO:2647: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2647 1 accagctgac aggtggagct gccagtctcc agtgctcagc cctcagcggg gcctgcctgg 61 cagccccaca cacagagggc atcggggtgg cgggggcacg tgttacacgg gggccctggg 121 tctgagtcat ccacttcctc cgagtctgga tgggaggacc cagcgcccct cctccgcccc 181 ctcctgatct ggaaggataa atggggaggg gagagccact gggtagaagg aacagggagt 241 ggccagggta agtccccact ctcagagacc ctgacatcag cgtcacctgg agcagagtgg 301 cccagcctca gactcagagc accaagaccc aggcccgcag gcctggaccc accccggtcc 361 ccccgtccca gctccattct tcaccccaca atctgtagcc cccagccctg ccctgtgagg 421 cccggccagg cccacgatgc tcctccttgc tccccagatg ctgaatctgc tgctgctggc 481 gctgcccgtc ctggcgagcc gcgcctacgc ggcccctggt gagtcccagc cggggtccac 541 cctgcccctc accacattcc acaggtcagg gcctgggtgg gttctgggga ggtcgggctg 601 gccccccaca cagggaaggg ctgggcccag gcctggggct gcttcctggt cctgacctgg 661 cacctgcccc agccccaggc caggccctgc agcgagtggg catcgtcggg ggtcaggagg 721 cccccaggag caagtggccc tggcaggtga gcctgagagt ccacggccca tactggatgc 781 acttctgcgg gggctccctc atccaccccc agtgggtgct gaccgcagcg cactgcgtgg 841 gaccgtgagt ctcccggggc ctggaggggt ggggaagggc tggatgtgag ccctggctcc 901 cgggtgctcc tgggggctgc ccagggccct gagtgggatc ctccgctgcc cagggacgtc 961 aaggatctgg ccgccctcag ggtgcaactg cgggagcagc acctctacta ccaggaccag 1021 ctgctgccgg tcagcaggat catcgtgcac ccacagttct acaccgccca gatcggagcg 1081 gacatcgccc tgctggagct ggaggagccg gtgaacgtct ccagccacgt ccacacggtc 1141 accctgcccc ctgcctcaga gaccttcccc ccggggatgc cgtgctgggt cactggctgg 1201 ggcgatgtgg acaatgatgg tgggtctggg gacagtggag gtggggccag ggtcttagcc 1261 acagcccagc ccctgggtcc ctctgggctc caggtggggg ttgcccggcc ccctcctgag 1321 gctgcaccct cttccccacc tgcagagcgc ctcccaccgc catttcctct gaagcaggtg 1381 aaggtcccca taatggaaaa ccacatttgt gacgcaaaat accaccttgg cgcctacacg 1441 ggagacgacg tccgcatcgt ccgtgacgac atgctgtgtg ccgggaacac ccggagggac 1501 tcatgccagg tgggccccgc ctgtcccccg ccccccgccc cccaaccccc actcccaggc 1561 ctgttcggcg agcgctgacc tctgaccttc ccagggcgac tccggagggc ccctggtgtg 1621 caaggtgaat ggcacctggc tgcaggcggg cgtggtcagc tggggcgagg gctgtgccca 1681 gcccaaccgg cctggcatct acacccgtgt cacctactac ttggactgga tccaccacta 1741 tgtccccaaa aagccgtgag tcaggcctgg gttggccacc tgggtcactg gaggaccaac 1801 ccctgctgtc caaaacacca ctgcttccta cccaggtggc gactgccccc cacaccttcc 1861 ctgccccgtc ctgagtgccc cttcctgtcc taagccccct gctctcttct gagccccttc 1921 ccctgtcctg aggacccttc cctatcctga gcccccttcc ctgtcctaag cctgacgcct 1981 gcaccgggcc ctccagccct cccctgccca gatagctggt ggtgggcgct aatcctcctg 2041 agtgctggac ctcattaaag tgcatggaaa tcactggtgt gcatcgctgt gtttctggtt 2101 gtggatgtca ctgggagaga aggggtccag gtgtgctgag gacacctgcc acagtgtgag 2161 gtcctagccc tcaaggcac gccagtcacc gtgggac (2) INFORMATION FOR SEQ ID NO:2648: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: _base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2648 1 ggaattccgt ggccaggatg ctgagcctgc tgctgctggc gctgcccgtc ctggcgagcc WO 00/09525 PCT/US99/17712 EPI-109 809 61 gcgcctacgc ggcccctgcc ccagtccagg ccctgcagca agcgggtatc gtcgggggtc 121 aggaggcccc caggagcaag tggccctggc aggtgagcct gagagtccgc gaccgatact 181 ggatgcactt ctgcgggggc tccctcatcc acccccagtg ggtgctgacc gcggcgcact 241 gcctgggacc ggacgtcaag gatctggcca ccctcagggt gcaactgcgg gagcagcacc 301 tctactacca ggaccagctg ctgccagtca gcaggatcat cgtgcaccca cagttctaca 361 tcatccagac tggagcggat atcgccctgc tggagctgga ggagcccgtg aacatctcca 421 gccgcgtcca cacggtcatg ctgccccctg cctcggagac cttccccccg gggatgccgt 481 gctgggtcac tggctggggc gatgtggaca atgatgagcc cctcccaccg ccatttcccc 541 tgaagcaggt gaaggtcccc ataatggaaa accacatttg tgacgcaaaa taccaccttg 601 gcgcctacac gggagacgac gtccgcatca tccgtgacga catgctgtgt gccgggaaca 661 gccagaggga ctcctgcaag ggcgactctg gagggcccct ggtgtgcaag gtgaatggca 721 cctggctaca ggcgggcgtg gtcagctggg acgagggctg tgcccagccc aaccggcctg 781 gcatctacac ccgtgtcacc tactacttgg actggatcca ccactatgtc cccaaaaagc 841 cgtgagtcag gcctgggtgt gccacctggg tcactggagg accaacccct gctgtccaaa 901 acaccactgc ttcctaccca ggtggcgact gccccccaca ccttccctgc cccgtcctga 961 gtgccccttc ctgtcctaag ccccctgctc tcttctgagc cccttcccct gtcctgagga 1021 cccttcccca tcctgagccc ccttccctgt cctaagcctg acgcctgcac tgctccggcc 1081 ctcccctgcc caggcagctg gtggtgggcg ctaatcctcc tgagtgctgg acctcattaa 1141 agtgcatgga aatc (2) INFORMATION FOR SEQ ID NO:2649: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: _base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2649 1 gctgcccgtc ctggcgagcc gcgcctacgc ggcccctgcc ccaggccagg ccctgcagcg 61 agtgggcatc gttgggggtc aggaggcccc caggagcaag tggccctggc aggtgagcct 121 gagagtccgc gaccgatact ggatgcactt ctgcgggggc tccctcatcc acccccagtg 181 ggtgctgacc gcagcgcact gcgtgggacc ggacgtcaag gatctggccg ccctcagggt 241 gcaactgcgg gagcagcacc tctactacca ggaccagctg ctgccggtca gcaggatcat 301 cgtgcaccca cagttctaca ccgcccagat cggagcggac atcgccctgc tggagctgga 361 ggagccggtg aaggtctcca gccacgtcca cacggtcacc ctgccccctg cctcagagac 421 cttccccccg gggatgccgt gctgggtcac tggctggggc gatgtggaca atgatgagcg 481 cctcccaccg ccatttcctc tgaagcaggt gaaggtcccc ataatggaaa accacatttg 541 tgacgcaaaa taccaccttg gcgcctacac gggagacgac gtccgcatcg tccgtgacga 601 catgctgtgt gccgggaaca cccggaggga ctcatgccag ggcgactccg gagggcccct 661 ggtgtgcaag gtgaatggca cctggctgca ggcgggcgtg gtcagctggg gcgagggctg 721 tgcccagccc aaccggcctg gcatctacac ccgtgtcacc tactacttgg actggatcca 781 ccactatgtc cccaaaaagc cgtgagtcag gcctggggtg tccacctggg tcactggagg 841 accagcccct cctgtccaaa acaccactgc ttcctaccca ggcggcgact gccccccaca 901 ccttccctgc cccgtcctga gtgccccttc ctgtcctaag ccccctgctc tcttctgagc 961 cccttcccct gtcctgagga cccttcccca tcctgagccc ccttccctgt cctaagcctg 1021 acgcctgcac cgggccctcc ggccctcccc tgcccaggca gctggtggtg ggcgctaatc 1081 C (2) INFORMATION FOR SEQ ID NO:2650: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: _base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2650 1 atctggaagc ataaatgggg aggggagagc ccactgggta gaaggaacag ggagcggcca 61 gggtaagtcc ccactctcag agaccctgac atcagcgtca cctggagcag agtggcccag 121 cttcagactc agagcaccaa gacccaggcc tgcaggcctg gacccacccc ggtccccccg 181 tcccagctcc attcttcacc ccacaatctg tagcccccag ccctgccctg tgaggcccgg 241 ccaggcccac gatgctcctc cttgctcccc agatgctgaa tctgctgctg ctggcgctgc 301 ccgtcctggc gagccgcgcc tacgcggccc ctggtgagtc ccagccgggg tccaccctgc 361 ccctcaccac attccacagg tcagggcctg ggtgggttct ggggaggtcg ggctggcccc 421 cacacaggga agggctgggc ccaggcctgg ggctgcttcc tggtcctgac ctggcacctg 481 ccccagcccc aggccaggcc ctgcagcgag tgggcatcgt tgggggtcag gaggccccca 541 ggagcaagtg gccctggcag gtgagcctga gagtccgcga ccgatactgg atgcacttct 601 gcgggggctc cctcatccac ccccagtggg tgctgaccgc agcgcactgc gtgggaccgt 661 gagtctcccg gggcctggag gggtggggaa gggctggatg tgagccctgg ctcccgggtg 721 ctcctggggg ctgcccaggg ccctgagtgg gatcctccgc tgcccaggga cgtcaaggat 781 ctggccgccc tcagggtgca actgcgggag cagcacctct actaccagga ccagctgctg 841 ccggtcagca ggatcatcgt gcacccacag ttctacaccg cccagatcgg agcggacatc WO 00/09525 PCTIUS99/17712 EPI-109 810 901 gccctgctgg agctggagga gccggtgaac gtctccagcc acgtccacac ggtcaccctg 961 ccccctgcct cagagacctt ccccccgggg atgccgtgct gggtcactgg ctggggcgat 1021 gtggacaatg atggtgggtc tggggacagt ggaggtgggg ccagggcctt agccacagcc 1081 cagcccctgg gctccctctg ggctccaggt gggggttgcc cggccccctc ctgaggctgc 1141 accctcttcc ccacctgcag agcgcctccc accgccattt cctctgaagc aggtgaaggt 1201 ccccataatg gaaaaccaca tttgtgacgc aaaataccac cttggcgcct acacgggaga 1261 cgacgtccgc atcgtccgtg acgacatgct gtgtgccggg aacacccgga gggactcatg 1321 ccaggtgggc cccgcctgtc ccccgccccc cgccccccaa cccccactcc caggcctgtt 1381 cggcgagcgc tgacctctga ccttcccagg gcgactccgg agggcccctg gtgtgcaagg 1441 tgaatggcac ctggctgcag gcgggcgtgg tcagctgggg cgagggctgt gcccagccca 1501 accggcctgg catctacacc cgtgtcacct actacttgga ctggatccac cactatgtcc 1561 ccaaaaagcc gtgagtcagg cctggggtgt ccacctgggt cactggagag ccagcccctc 1621 ctgtccaaaa caccactgct tcctacccag gtggcgactg ccccccacac cttccctgcc 1681 ccgtcctgag tgccccttcc tgtcctaagc cccctgctct cttctgagcc ccttcccctg 1741 tcctgaggac ccttccccat cctgagcccc cttccctgtc ctaagcctga cgcctgcacc 1801 gggccctccg gccctcccct gcccaggcag ctggtggtgg gcgctaatcc tcctgagtgc 1861 tggacctcat taaagtgcat ggaaatcact ggtgtgcatc gctgtgtttc tggttgtgga 1921 tgtcactggg agagaagggg tccaggtgtg ctgaggacac ctgccacagt gtgaggtcct 1981 agccctcaag gcacagccag tcaccgtggg acggggcctc ctgggcagcc ctggtccccg 2041 aggctggctt ctccccacac gatgcatcca gcattcgggt cacacagagc cactcgggca 2101 actcagttga ttataaagga cagccaggtc cctgcaaccg ggtcaagaca gaaatggtca 2161 ccgggaaccc cagggctgcc catcacgagc ccctacccca cgcttcccac gagctcttct 2221 cccggccctc ccgtccatgc ttgtgctttg cctaattgtt tgcttttgag aacgggattg (2) INFORMATION FOR SEQ ID NO:2651: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2651 1 gggtctcaag gaatctttat tctgcgtctt cattctgaac tggatggaac cttcctgagc 61 gcagagtcct ttccactgtg aattatgggt ttgttatcgt ttttgttcgt tgctggttgt 121 acgtgacggg agttcagctt tttgctgcgg gacggcagag ataggatgcg gggcttcctg 181 agaggcgccg gggcagggcc gcacaggtcc atccacctcc cctgggaccc cagccctgca 241 gcagccccag gggagcggcc ggggatcggg gcggggtgcc caggacgcgc cctgattggc 301 ccagtgttag ccaatcaagg ctctcgcatc cccatggtgc tgattggtcc gcctcccagg 361 cctgacccaa tcggagcatt cctaggagga gcggccccag agcgcctgac tcgggggtcc 421 cagagccctc tgcacaccac agccccggtg tccccgtgtg tccctgggtt ctcccagccc 481 tggtgtcccc tgagtctctt cttcaccgtc agccctggtg tctcccgtgt ccctgccaca 541 ccctcatccc tggtgtcccc cgtcacccca tcccctcacc tcctgggctc ctgaaggtcc 601 catcttgtgg gcctcattca tggaaccagg acggggcagg tggaggcctc tggggagttt 661 gtccagagaa tggaggagaa gcagggtcat gagcaggagc ggtctgggcc acccctgcct 721 gtcccccggg gggtgcagcc cggaaggagt ccagatggat atggccccgc agtgcagagt 781 cagccccaaa ccaggctggt cccaggcagg gtgggggcag gaggagcccc ggagtggccc 841 tgtgttgggg gtcggggggc aggcaggggg tcctggggct cagaagcgga ggaggtgggc 901 tggaggcccc agtgaccaac aggcccacgg gagtcgggag gtggggtgga cggacctgca 961 gggacagtgt cagcgctgaa tgggatggag agcacaggga gctggggccg gggatgagac 1021 catggggagc tggggctggg gctgggacta gtccatgggg agctggggct gaagttgggg 1081 gtgagtccat ggggagctgg gctgggcctc ctggggttgc acctgcactc ctctctgctc 1141 ttccctctgc gtatgaagct cagatcccat gataaggagg cacctgcaga ccaggggacc 1201 tgcacggaca gccccagagg tggacattga ggactcgtag gaggacttgg gtctcatacg 1261 gcgggtgggg agcagggccc cttcctggct gaggacactt ggtgctgtcc cctctcaagg 1321 ctgtttcccc atctgacaaa ggggtctcat gtgagccccc aaccaaatga gtcgaggagg 1381 gctggcccca cccccgtgga tttggagtcc gtaggagggg tgtcacccgt cacgtcccca 1441 ccccgtgggc accttcccgt ctcttggagc gtggcccatg gacatgagtt cctcacccgt 1501 gtccctcttg gggaaacagg tttcaggagc gacgggtctt gtagcctggg gcagccaggc 1561 cacctgggtg cagctatgcc tgaaggcctc ctggcaccga gacaggggca ggagcagatc 1621 ccaccagcgg gaaggtggtg cgttctgatg ctgggatcca ccagctgaca ggtggagctg 1681 cgagcctcca gtgctcagcc ctcggcgggg cctgcctggc agccccacac acagagggca 1741 tcggggtggc gggggcacgt gttacacggg ggccctgggt ctgagtcatc cacttcctcc 1801 gagtctggat gggaggaccc agcgcccctc ctccgccccc tcctgatctg gaaggataaa 1861 tggggagggg agagcccgct gggtagaagg aacagggagt ggccagggta agtccctact 1921 ctcagagacc ctgacatcag tgtcacctgg agcagagtgg cccagcctca gactcagagc 1981 accaagaccc aggcccgcag gcctggaccc accccggtcc ccccgtccca gctccattct 2041 tcaccccaca atctgtagcc cccagccctg ccctgtgagg cccggccagg cccacgatgc 2101 tcctccttgc tccccagatg ctgagcctgc tgctgctggc gctgcccgtc ctggcgagcc 2161 cggcctacgc ggcccctggt gagtcccagc cggggtccac cctgcccctc accacattcc 2221 acaggtcagg gcctgggtgg gttctgggga ggctgggctg gcccccacac agggaagggc WO 00/09525 PCTIUS99/17712 EPI-109 811 2281 tgggcccagg cgtggggctg cttcctggtc ctgacctggc acctgcccca gccccagtcc 2341 aggccctgca gcaagcgggt atcgtcgggg gtcaggaggc ccccaggagc aagtggccct 2401 ggcaggtgag cctgagagtc cgcgaccgat actggatgca cttctgtggg ggctccctca 2461 tccaccccca gtgggtgctg accgcggcgc actgcctggg accgtgagtc tcccagggcc 2521 tggaggggtg ggcaagggct ggatgtgagc cctggctccc gggtgctcct gggggctgcc 2581 cagggccctg agtgggatcc tccgctgccc agggacgtca aggatctggc caccctcagg 2641 gtgcaactgc gggagcagca cctctactac caggaccagc tgctgccggt cagcaggatc 2701 atcgtgcacc cacagttcta catcatccag actggagcgg atatcgccct gctggagctg 2761 gaggagcccg tgaacatctc cagccgcgtc cacacggtca tgctgccccc tgcctcggag 2821 accttccccc cggggatgcc gtgctgggtc actggctggg gcgatgtgga caatgatggt 2881 gggtctgggg acagtgggag gtggggccag ggtcttagcc acagcccagc ccctgggctc 2941 caggtggggg ttgcccggcc ccctcctcag gctgcaccct cttccccacc tgcagagccc 3001 ctcccaccgc catttcccct gaagcaggtg aaggtcccca taatggaaaa ccacatttgt 3061 gacgcaaaat accaccttgg cgcctacacg ggagacgacg tccgcatcat ccgtgacgac 3121 atgctgtgtg ccgggaacac ccggagggac tcatgccagg tgggccccgc gtgtcccccg 3181 ccccccgcac cccaaccccc actcccaggo ctgttcggcg agcgctgacc tctgaccttc 3241 ccagggcgac tctggagggc ccctggtgtg caaggtgaat ggcacctggc tacaggcggg 3301 cgtggtcagc tgggacgagg gctgtgccca gcccaaccgg cctggcatct acacccgtgt 3361 cacctactac ttggactgga tccaccacta tgtccccaaa aagccgtgag tcaggcctgg 3421 ggtgtccacc tgggtcactg gagagccagc ccctcctgtc caaaacacca ctgcttccta 3481 cccaggtggc gactgccccc cacaccttcc ctgccccgtc ctgagtgccc cttcctgtcc 3541 taagccccct gctctcttct gagccccttc ccctgtcctg aggacccttc cccatcctga 3601 gcccccttcc ctgtcctaag cctgacgcct gcactgggcc ctccggccct cccctgccca 3661 ggcagctggt ggtgggcgct aatcctcctg agtgctggac ctcattaaag tgcatggaaa 3721 tcactggtgt gcatcgctgt gtttctggtt gtggatgtca ctgggagaga aggggtccag 3781 gtgtgctgag gacacctgcc acagtgcgag gtcctagccc tcaaggcaca gccagtcacc 3841 gtgggacggg gcctcctggg cagccctggt ccccggggct ggcttctccc cacacgatgc 3901 atccagcatt cgggtcacac agagccactc gggcaactca gttgattata aaggacagcc 3961 aagtccctgc aaccgggtca agacagagaa tggtcgccgg gagccccagg gctgcccatc 4021 acgagcccct accccacgct tcccacgagc tcttctcccg gcccctctgt ccactgcttg 4081 tgctttgccc tagttgtttg ctttgagaca ggatctcgct gtgtcatcca ggctgaagtg 4141 cagtggtgtg atcagggctc actgtagcct tgaactcctg ggctcaagcg atcctcccat 4201 cttggcctcc catatagctg ggccacagga gtgagccacc acgcccagtt aatttttgta 4261 ttttcagtag agatggggtt tcgccatgtt ggccagtctg gtctcgaact cctgacctca 4321 agtgatctgc ccgcctcggc ctcccaaagt gctgggatga caggcgtgag ccaccgcacc 4381 cagcctgagt ttgacatttt caaattcatt ttgaggtctt tctctacatc aatacatgag 4441 ccctccgcgt ccggcgagtg ttgcatttta tcccgggctc ttgtttgcat tttatatttg 4501 aacatgatta cattcaggaa tgaaatgcgg ggctgttctg gttgaaaaca actctctaaa 4561 gaaacattca ctctttcctt ccaactgtca gatgcagaga tgtgcattta gtctctccaa 4621 tctctgcaaa tgacctctgt cctcacaagg ggtggactcg acttccagcg ccctctccag 4681 ccccacgtga cctctgcctc tgcagcccct gaaggcccat ccctcggctc ctgttctgca 4741 ggcccagcgt cttgtctatg aagatggacc tggaactcgg gccctccttc ctccctctgg 4801 cccatcccac cttctaggga tcacagagac agcacggggt gacccccagg gaacactgag 4861 cccctagaag cacttccaca cgcccactgg aggttttgcg gggtgggagt cggagggatg 4921 agaccccgaa gggaagcaag acggcccctc aggacagggc tgccggtgta aggaaaggtg 4981 gacagcaggg gccggtcact gggtggaggg ggagggcagg ctccagcccc agagcttccc 5041 aaattagatc taagatccct gggaagctca gtgaagctca gcgcagtgac actggcagat 5101 gtgagcgtca gcttcagcag gaagggtctc tcaggacgtg acaggcaggc tgctggccag 5161 ggctgcagcc acctgcgttt tgactgggac gggggcacct gatccaaggt cacccacgtg 5221 gctgccggca ggaggccctg gttccccgtc acaagggggt gtgaggggga aggccaagtg 5281 gtggccacan ggttnccacc gagagggaca gtgcccaagt tggccaagcc accctnggac 5341 aagaaacaat nccaagtctt nccaaggtcc ttggacaaca aggagaancc cccccagctt 5401 gggggcnatt aaccaagggc cangnccccc cttcccggtt c 1 tggacccacc ccggtccccc cgtcccagct tccattcttc accccacaat ctgtagcccc 61 cagccctgcc ctgtgaggcc cggccaggcc cacgatgctc ctccttgctc cccagatgct 121 gaatctgctg ctgctggcgc tgcccgtcct ggcgagccgc gcctacgcgg cccctggtga 181 gtcccagccg gggtccaccc tgcccctcac cacattccac aggtcagggc ctgggtgggt 241 tctggggagg ccgggctggc ccccacacag ggaagggctg ggcccaggcc tggggctgct 301 tcctggtcct gacctggcac ctgccccagc cccaggccag gccctgcagc gagtgggcat 361 cgttgggggt caggaggccc ccaggagc 1 cagatcggag cggacatcgc cctgctggag ctggaggagc cggtgaaggt ctccagccac 61 gtccacacgg tcaccctgcc ccctgcctca gagaccttcc ccccggggat gccgtgctgg 121 gtcactggct ggggcgatgt ggacaatgat ggtgggtctg gggacagtgg aggtggggcc 181 agggtcttag ccacagccca gcccctgggc tccctctggg ctccaggtgg gggttgcccg 241 gccccctcct gaggctgcac cctcttcccc acctgcagag cgcctcccac cgccatttcc 301 tctgaagcag gtgaaggtcc ccataatgga aaaccacatt tgtgacgcaa aataccacct 361 tggcgcctac acgggagacg acgtccgcat cgtccgtgac gacatgctgt gtgccgggaa 421 cacccggagg gactcatgcc aggtgggccc cgcgtgtccc ccgccccccg caccccaacc WO 00/09525 PCT/US99/17712 EPI-109 812 481 cccactccca ggcctgttcg gcgagcgctg acctctgacc ttcccaaggc gactccggag 541 ggcccctggt gtgcaaggtg aatggcacct ggctgcaggc gggcgzagtc agctggggcg 601 agggctgtgc ccagcccaac cggcctggca tctacacccg tgtcacctac tacttggact 661 ggatccacca ctatgtcccc aaaaagccgt gagtcaggcc tgggtzagcc acctgggtca 721 ctggaggacc aacccctgct gtccaaaaca ccactqcttc ctacccaggt ggcgactgcc 781 ccccacacct tccctgcccc gtcctgagtg ccccttcctg tcctaagccc cctgctctct 841 tctgagcccc ttcccctgtc ctgaggaccc ttccccatcc tgagccccct tccctgtcct 901 aagcctgacg cctgcactgg gccctccggc cctcccctgc ccaggcagct ggtggtgggc 961 gctaatcctc ctgagtgctg gacctcatta aagtgcatgg aaatcactgg tgtgcatcgc 1021 tgtgtttctg gttgtggatg tcactgggag agaaggggtc caggtatgct gaggacacct 1081 gccacagtgt gaggtcctag ccctcaaggc acaagccagt caccgtagga cggggcctct 1141 gggcagccct ggtccccgag ctggctt 1 ccaggatgct gaatctgctg ctgctggcgc tgcccgtcct ggcgaaccgc gcctacgcgg 61 cccctgcccc aggccaggcc ctgcagcgag tgggcatcgt tgggggtcag gaggccccca 121 ggagcaagtg gccctggcag gtgagcctga gagtccacgg cccatactgg atgcacttct 181 gcgggggctc cctcatccac ccccagtggg tgctgaccgc agcgcactgc gtgggaccgg 241 acgtcaagga tctggccgcc ctcagggtgc aactgcggga gcagcacctc tactaccagg 301 accagctgct gccggtcagc aggatcatcg tgcacccaca gttctacacc gcccagatcg 361 gagcggacat cgccctgctg gagctggagg agccggtgaa ggtctcoagc cacgtccaca 421 cggtcaccct gccccctgcc tcagagacct tccccccggg gatgccgtgc tgggtcactg 481 gctggggcga tgtggacaat gatgagcgcc tcccaccgcc atttcczctg aagcaggtga 541 aggtccccat aatggaaaac cacatttgtg acgcaaaata ccaccttggc gcctacacgg 601 gagacgacgt ccgcatcgtc cgtgacgaca tgctgtgtgc cgggaacacc cggagggact 661 catgccaggg cgactccgga gggcccctgg tgtgcaaggt gaatggcacc tggctgcagg 721 cgggcgtggt cagctggggc gagggctgtg cccagcccaa ccggcctggc atctacaccc 781 gtgtcaccta ctacttggac tggatccacc actatgtccc caaaaagccg tgagtcaggc 841 ctgggtgtgc cacctgggtc actggaggac caacccctgc tgtccaaaac accactgctt 901 cctacccagg tggcgactgc cccccacacc ttccctgccc cgtccz agt gccccttcct 961 gtcctaagcc ccctgctctc ttctgagccc cttcccctgt cctgaggacc cttccccatc 1021 ctgagccccc ttccctgtcc taagcctgac gcctgcactg ctccggccct cccctgccca 1081 ggcagctggt ggtgggcgct aatcctcctg agtgctggac ctcattaaag tgcatggaaa 1141 ica 1 ggccaggatg ctgaatctgc tgctgctggc gctgcccgtc ctggcgagcc gcgcctacgc 61 ggcccctgcc ccaggccagg ccctgcagcg agtgggcatc gttgggggtc aggaggcccc 121 caggagcaag tggccctggc aggtgagcct gagagtccac ggcccatact ggatgcactt 181 ctgcgggggc tccctcatcc acccccagtg ggtgctgacc gcagcgcact gcgtgggacc 241 ggacgtcaag gatctggcc g ccctcagggt gcaactgcgg gagcagcacc tctactacca 301 ggaccagctg ctgccggtca gcaggatcat cgtgcaccca cagttctaca ccgcccagat 361 cggagcggac atcgccctgc tggagctgga ggagccggtg aaggtctcca gccacgtcca 421 cacggtcacc ctgccccctg cctcagagac cttccccccg gggatgccgt gctgggtcac 481 tggctggggc gatgtggaca atgatgagcg cctcccaccg ccatttcctc tgaagcaggt 541 gaaggtcccc ataatggaaa accacatttg tgacgcaaaa taccaccttg gcgcctacac 601 gggagacgac gtccgcatcg tccgtgacga catgctgtgt gccgggaaca cccggaggga 661 ctcatgccag ggcgactccg gagggcccct ggtgtgcaag gtgaatggca cctggctgca 721 ggcgggcgtg gtcagctggg gcgagggctg tgcccagccc aaccggcctg gcatctacac 781 ccgtgtcacc tactacttgg actggatcca ccactatgtc cccaaaaagc cgtgagtcag 841 gcctgggttg gccacctggg tcactggagg accaacccct gctgtccaaa acaccactgc 901 ttcctaccca ggtggcgact gccccccaca ccttccctgc cccgtcctga gtgccccttc 961 ctgtcctaag ccccctgctc tcttctgagc cccttcccct gtcctgagga cccttcccca 1021 tcctgagccc ccttccctgt cctaagcctg acgcctgcac cgggccctcc ggccctcccc 1081 tgcccaggca gctggtggtg ggcgctaatc ctcctgagtg ctggacctca ttaaagtgca 1141 tggaa 1 tgaatctgct gctgctggcg ctgcccgtcc tggcgagccg cgcctacgcg gcccctgccc 61 caggccaggc cctgcagcga gtgggcatcg tcgggggtca ggaggccccc aggagcaagt 121 ggccctqgca ggcgagcctg agagtccacg gcccatactg gatgcacttc tgcggggqct 181 ccctcatcca cccccagtgg gtgctgaccg cagcgcactg cgtgggaccg gacgtcaagg 241 atctggccgc cctcagggtg caactgcggg agcagcacct ctactaccag gaccagctgc 301 tgccggtcag caggatcatc gtgcacccac agttctacac cgcccagatc ggagcggaca 361 tcgccctgct ggagctggag gagccggtga acgtctccag ccacgtccac acggtcaccc 421 tgccccctgc ctcagagacc ttccccccgg ggatgccgtg cgggtcact ggctggggcg 481 atgtggacaa tgatgagcgc ctcccaccgc catttcctct gaagcacgtg aaggtcccca 541 taatggaaaa ccacatttgt gacgcaaaat accaccttgg cgcctacacg ggagacgacg 601 tccgcatcgt ccgtgacgac atgctgtgtg ccgggaacac ccggagggac tcatgccagg 661 gcgactccgg agggcccctg gtgtgcaagg tgaatggcac ctggctgcag gcgggcgtgg 721 tcagctgggg cgagggctgt gcccagccca accggcctgg catctacacc cgtgtcacct 781 actacttgga ctggatccac cactatgtcc ccaaaaagcc gtgagtcagg cctgggttgg 841 ccacctgggt cactggagga ccaacccctg ctgtccaaaa caccactgct tcctacccag 901 gtggcgactg ccccccacac cttccctgcc ccgtcctgag tgccccttcc tgtcctaagc WO 00/09525 PCT/US99/17712 EPI-109 813 961 cccctgctct cttctgagcc ccttcccctg tcctgaggac ccttccctat cctgagcccc 1021 cttccctgtc ctaagcctga cgcctgcacc gggccctcca gccctcccct gcccagatag 1081 ctggtggtgg gcgctaatcc tcctgagtgc tggacctcat taaagtgcat ggaaatc 1 accagctgac aggtggagct gccagtctcc agtgctcagc cctcagcggg gcctgcctgg. 61 cagccccaca cacagagggc atcggggtgg cgggggcacg tgttacacgg gggccctggg 121 tctgagtcat ccacttcctc cgagtctgga tgggaggacc cagcgcccct cctccgcccc 181 ctcctgatct ggaaggataa atggggaggg gagagccact gggtagaagg aacagggagt 241 ggccagggta agtccccact ctcagagacc ctgacatcag cgtcacctgg agcagagtgg 301 cccagcctca gactcagagc accaagaccc aggcccgcag gcctggaccc accccggtcc 361 ccccgtccca gctccattct tcaccccaca atctgtagcc cccagccctg ccctgtgagg 421 cccggccagg cccacgatgc tcctccttgc tccccagatg ctgaatctgc tgctgctggc 481 gctgcccgtc ctggcgagcc gcgcctacgc ggcccctggt gagtcccagc cggggtccac 541 cctgcccctc accacattcc acaggtcagg gcctgggtgg gttctgggga ggtcgggctg 601 gccccccaca cagggaaggg ctgggcccag gcctggggct gcttcctggt cctgacctgg 661 cacctgcccc agccccaggc caggccctgc agcgagtggg catcgtcggg ggtcaggagg 721 cccccaggag caagtggccc tggcaggtga gcctgagagt ccacggccca tactggatgc 781 acttctgcgg gggctccctc atccaccccc agtgggtgct gaccgcagcg cactgcgtgg 841 gaccgtgagt ctcccggggc ctggaggggt ggggaagggc tggatgtgag ccctggctcc 901 cgggtgctcc tgggggctg!c ccagggccct gagtgggatc ctccgctgcc cagggacgtc 961 aaggatctgg ccgccctcag ggtgcaactg cgggagcagc acctctacta ccaggaccag 1021 ctgctgccgg tcagcaggat catcgtgcac ccacagttct acaccgccca gatcggagcg 1081 gacatcgccc tgctggagct ggaggagccg gtgaacgtct ccagccacgt ccacacggtc 1141 accctgcccc ctgcctcaga gaccttcccc ccggggatgc cgtgctgggt cactggctgg 1201 ggcgatgtgg acaatgatgg tgggtctggg gacagtggag gtggggccag ggtcttagcc 1261 acagcccagc ccctgggtcc ctctgggctc caggtggggg ttgcccggcc ccctcctgag 1321 gctgcaccct cttccccacc tgcagagcgc ctcccaccgc catttcctct gaagcaggtg 1381 aaggtcccca taatggaaaa ccacatttgt gacgcaaaat accaccttgg cgcctacacg 1441 ggagacgacg tccgcatcgt ccgtgacgac atgctgtgtg ccgggaacac ccggagggac 1501 tcatgccagg tgggccccgc ctgtcccccg ccccccgccc cccaaccccc actcccaggc 1561 ctgttcggcg agcgctgacc tctgaccttc ccagggcgac tccggagggc ccctggtgtg 1621 caaggtgaat ggcacctggc tgcaggcggg cgtggtcagc tggggcgagg gctgtgccca 1681 gcccaaccgg cctggcatct acacccgtgt cacctactac ttggactgga tccaccacta 1741 tgtccccaaa aagccgtgag tcaggcctgg gttggccacc tgggtcactg gaggaccaac 1801 ccctgctgtc caaaacacca ctgcttccta cccaggtggc gactgccccc cacaccttcc 1861 ctgccccgtc ctgagtgccc cttcctgtcc taagccccct gctctcttct gagccccttc 1921 ccctgtcctg aggacccttc cctatcctga gcccccttcc ctgtcctaag cctgacgcct 1981 gcaccgggcc ctccagccct cccctgccca gatagctggt ggtgggcgct aatcctcctg 2041 agtgctggac ctcattaaag tgcatggaaa tcactggtgt gcatcgctgt gtttctggtt 2101 gtggatgtca ctgggagaga aggggtccag gtgtgctgag gacacctgcc acagtgtgag 2161 gtcctagccc tcaaggcaca gccagtcacc gtgggac 1 ggaattccgt ggccaggatg ctgagcctgc tgctgctggc gctgcccgtc cggcgagcc 61 gcgcctacgc ggcccctgcc ccagtccagg ccctgcagca agcgggtatc gtcgggggtc 121 aggaggcccc caggagcaag tggccctggc aggtgagcct gagagtccgc gaccgatact 181 ggatgcactt ctgcgggggc tccctcatcc acccccagtg ggtgctgacc gcggcgcact 241 gcctgggacc ggacgtcaag gatctggcca ccctcaggg gcaactgcgg gagcagcacc 301 tctactacca ggaccagctg ctgccagtca gcaggatcat cgtgcaccca cagttctaca 361 tcatccagac tggagcggat atcgccctgc tggagctgga ggagcccgtg aacatctcca 421 gccgcgtcca cacggtcatg ctgccccctg cctcggagac cttccccccg gggatgccgt 481 gctgggtcac tggctggggc gatgtggaca atgatgagcc cctcccaccg ccatttcccc 541 tgaagcaggt gaaggtcccc ataatggaaa accacatttg tgacgcaaaa taccaccttg 601 gcgcctacac gggagacgac gtccgcatca tccgtgacga catgctgtgt gccgggaaca 661 gccagaggga ctcctgcaag ggcgactctg gagggcccct ggtgtgcaag gtgaatggca 721 cctggctaca ggcgggcgtg gtcagctggg acgagggctg tgcccagccc aaccggcctg 781 gcatctacac ccgtgtcacc tactacttgg actggatcca ccactatgtc cccaaaaagc 841 cgtgagtcag gcctgggtgt gccacctggg tcactggagg accaacccct gctgtccaaa 901 acaccactgc ttcctaccca ggtggcgact gccccccaca ccttccctgc cccgtcctga 961 gtgcccctc ctgtcctaag ccccctgctc tcttctgagc cccttcccct gtcctgagga 1021 cccttcccca tcctgagccc ccttccctgt cctaagcctg acgcctgcac tgctccggcc 1081 ctcccctgcc caggcagctg gtggtgggcg ctaatcctcc tgagtgccgg acctcattaa 1141 agtgcatgga aatc 1 gctgcccgtc ctggcgagcc gcgcctacgc ggcccctgcc ccaggccagg ccctgcagcg 61 agtgggcatc gttgggggtc aggaggcccc caggagcaag tggccctggc aggtgagcct 121 gagagtccgc gacggatact ggatgcactt ctgcgggggc tccctcatcc acccccagtg 181 ggtgctgacc gcagcgcact gcgtgggacc ggacgtcaag gatctggccg ccctcagggt 241 gcaactgcgg gagcagcacc tctactacca ggaccagctg ctgccggtca gcaggatcat 301 cgtgcaccca cagttctaca ccgcccagat cggagcggac atcgccctgc tggagctgga 361 ggagccggcg aaggtctcca gccacgtcca cacggtcacc ctgccccctg cctcagagac 421 cttccccccg gggatgccgt gctgggtcac tggctggggc gatgtggaca atgatgagcg WO 00/09525 PCT/US99/17712 EPI-109 814 481 cctcccaccg ccatttcctc tgaagcaggt gaaggtcccc ataatggaaa accacatttg 541 tgacgcaaaa taccaccrtg gcgcctacac gggagacgac gtccgcatcg tccgtgacga 601 catgctgtgt gccgggaaca cccggaggga ctcatgccag ggcgactccg gagggcccct 661 ggtgtgcaag gcgaatagca cctggctgca ggcgggcgtg gtcagctggg gcgagggctg 721 tgcccagccc aaccggcctg gcatctacac ccgtgtcacc tactacttgg actggatcca 781 ccactatgtc cccaaaaagc cgtgagtcag gcctggggtg tccacctggg tcactggagg 841 accagcccct cctgtccaaa acaccactgc ttcctaccca ggcggcgact gccccccaca 901 ccttccctgc cccgtcczga gtgccccttc ctgtcctaag ccccctgctc tcttctgagc 961 cccttcccct gtcctgagga cccttcccca tcctgagccc ccttccctgt cctaagcctg 1021 acgcctgcac cgggccctcc ggccctcccc tgcccaggca gctggtggtg ggcgctaatc 1081 c 1 atctggaagc ataaatgggg aggggagagc ccactgggta gaaggaacag ggagcgqcca 61 gggtaagtcc ccactctcag agaccctgac atcagcgtca cctggagcag agtggcccag 121 cttcagactc agagcaccaa gacccaggcc tgcaggcctg gacccacccc ggtccccccg 181 tcccagctcc attcttcacc ccacaatctg tagcccccaq ccctgccctg tgaggcccgg 241 ccaggcccac gatgctcctc cttgctcccc agatgctgaa tctgctgctg ctggcgctgc 301 ccgtcctggc gagccgcgcc tacgcggccc ctggtgagtc ccagccgggg tccaccctgc 361 ccctcaccac attccacagg tcagggcctg ggtgggttct ggggaggtcg ggctggcccc 421 cacacaggga agggctgggc ccaggcctgg ggctgcttcc tggtcctgac ctggcacctg 481 ccccagcccc aggccaggcc ctgcagcgag tgggcatcgt tgggggtcag gaggccccca 541 ggagcaagtg gccctggcag gtgagcctga gagtccgcga ccgatactgg atgcacttct 601 gcgggggctc cctcatccac ccccagtggg tgctgaccgc agcgcactgc gtgggaccgt 661 gagtctcccg gggcctggag gggtggggaa gggctggatg tgagccctgg ctcccgggtg 721 ctcctggggg ctgcccaggg ccctgagtgg gatcctccgc tgcccaggga cgtcaaggat 781 ctggccgccc tcagggtgca actgcgggag cagcacctct actaccagga ccagctgctg 841 ccggtcagca ggatcatcgt gcacccacag ttctacaccg cccagatcgg agcggacatc 901 gccctgctgg agctggagga gccggtgaac gtctccagcc acgtccacac ggtcaccctg 961 ccccctgcct cagagacctt ccccccgggg atgccgtgct gggtcactgg ctggggcgat 1021 gtggacaatg atggtgggtc tggggacagt ggaggtgggg ccagggtctt agccacagcc 1081 cagcccctgg gctccctctg ggctccaggt gggggttgcc cggccccctc ctgaggctgc 1141 accctcttcc ccacctgcag agcgcctccc accgccattt cctctgaagc aggtgaaggt 1201 ccccataatg gaaaaccaca tttgtgacgc aaaataccac cttggcgcct acacgggaga 1261 cgacgtccgc atcgtccgtg acgacatgct gtgtgccggg aacacccgga gggactcatg 1321 ccaggtgggc cccgcctgtc ccccgccccc cgccccccaa cccccactcc caggcctgtt 1381 cggcgagcgc tgacctctga ccttcccagg gcgactccgg agggcccctg gtgtgcaagg 1441 tgaatggcac ctggctgcag gcgggcgtgg tcagctgggg cgagggctgt gcccagccca 1501 accggcctgg catctacacc cgtgtcacct actacttgga ctggatccac cactatgtcc 1561 ccaaaaagcc gtgagtcagg cctggggtgt ccacctgggt cactggagag ccagcccctc 1621 ctgtccaaaa caccactgct tcctacccag gtggcgactg ccccccacac cttccctgcc 1681 ccgtcctgag tgccccttcc tgtcctaagc cccctgctct cttctgagcc ccttcccctg 1741 tcctgaggac ccttccccat cctgagcccc cttccctgtc ctaagcctga cgcctgcacc 1801 gggccctccg gccctcccct gcccaggcag ctggtggtgg gcgctaatcc tcctgagtgc 1861 tggacctcat taaagtgcat ggaaatcact ggtgtgcatc gctgtgtttc tggttgtgga 1921 tgtcactggg agagaagggg tccaggtgtg ctgaggacac ctgccacagt gtgaggtcct 1981 agccctcaag gcacagccag tcaccgtggg acggggcctc ctgggcagcc ctggtccccg 2041 aggctggctt ctccccacac gatgcatcca gcattcgggt cacacagagc cactcgggca 2101 actcagttga ttataaagga cagccaggtc cctgcaaccg ggtcaagaca gaaatggtca 2161 ccgggaaccc cagggctgcc catcacgagc ccctacccca cgcttcccac gagctcttct 2221 cccggccctc ccgtccatgc ttgtgctttg cctaattgtt tgcttttgag aacgggattg (2) INFORMATION FOR SEQ ID NO:2652: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2652 1 ttctccttct ccccaacagt tccccaggga cctctctcta atcagccctc tggcccaggc 61lagtcagatca tcttctcgaa ccccgagtga caagcctgta gcccatgttg tagcaaaccc 121 tcaagctgag gggcagctcc agtggctgaa ccgccgggcc aatgccctcc tggccaatgg 181 cgtggagctg agagataacc agctggtggt gccatcagag ggcctgtacc tcatctactc 241 ccaggtcctc ttcaagggcc aaggctgccc ctccacccat gtgctcctca cccacaccat 301 cagccgcatc gccgtctcct accagaccaa ggtcaacctc ctctctgcca tcaagagccc 361 ctgccagagg gagaccccag agggggctga ggccaagccc cggtatgagc ccatctatct 421 gggaggggtc ttccagctgg agaagggtga ccgactcagc gccgagatca atcggcccga 481 ctatctcgac tttgccgagt ctgggcaggt ctactttggg atcattgccc tgtgaggagg 541 acgaacatcc aaccttccca aacgcctccc ctgccccaat ccctttatta ccccctcctt 601 cagacaccct caacctcttc tggctcaaaa agagaattgg gggcttaggg tcggaaccca WO 00/09525 PCT/US99/17712 EPI-109 815 661 agcttagaac tttaagcaac aagaccacca cttcgaaacc tgggattcag gaatgtgtgg 721 cctgcacagt gaattgczgg caaccactaa gaattcaaac tggggcctcc agaactcact 781 ggggcctaca gctttgat-cc ctgacatctg gaatctggag accagggagc ctttggttct 841 ggccagaatg ctgcaggact tgagaagacc tcacctagaa attgacacaa gtggacctta 901 ggccttcctc tctccagatg tttccagact tccttgagac acggagccca gccctcccca 961 tggagccagc tccctctatt tatgtttgca cttgtgatta tttattattt atttattatt 1021 tatttattta cagatgaatg tatttatttg ggagaccggg gtatcctggg ggacccaatg 1081 taggagcrgc cttggctcag acatgttttc cgtgaaaacg gagctgaaca ataggctgtt 1141 cccatgtagc cccctggcct ctgtgccttc ttttgattat gttttttaaa atatttatct 1201 gattaagttg tctaaacaat gctgatttgg tgaccaactg tcactcattg ctgagcctct 1261 gctccccagg ggagttgtgt ctgtaatcgc cctactattc agtggcgaga aataaagttt 1321 gctt (2) INFORMATION FOR SEQ ID NO:2653: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: _base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2653 1 tacgggccgg gcactcccga gctgctgctc gagggcgccg agacggtgac tccagtgctg 61 gacccggcca ggagacaaqg gtacgggcct ctctggtaca cgagcgtggg gttcggcggc 121 ctggtgcagc tccggagggg cgagagggtg tacgtcaaca tcagtcaccc cgatatggtg 181 gacttcgcga gagggaagac cttctttggg gccgtgatgg tggggtgagg gaatatgagt 241 gcgtggtgcg agtgcgtgaa tattgggggn ccggacgccc aggaccccat ggcagtggga 301 aaaatgtagg agactgtttg gaaattgatt ttgaacctga tgaaaataaa gaatggaaag 361 cttcagtgct gccgataaag atgctgagtt gcgacacacg tcttaattca gggtgggtgc 421 acgggtgcgg gttaaatatt ctcagtactc ttctggttgc ttgaaacaat tcatcacaac 481 acagtgtatg gcctttgctc ctagggatga tggtctgcct gtcccacccc ctccctgcct 541 ctgaatggcc aggccccacc attagcccag ttggagggtg ggaggaaggg ggacttctca 601 aactccgaag cttctctagg catcctgatt ttcagggcca catggtccca accagactct 661 gcaccatact cttttctctt gggtaccccc caacagtgag aggggtcatt acagagccca 721 gcaagcacca ctcagaaagg cccagcagca gagtaagccc ctatcatgac agaggaatga 781 agcctggagg ggccccgcac ttctccccct agagctgcct gaaggcctct ctgtctccta 841 cccgacagtc aactcttctc ctccaaggag cttaattcaa ggctcatggg gtctgaaggg 901 aggaggctga aggagaaaga aggggagaat attagagaga gatggggatg gcaggaagga 961 gcctgtggtg cctgaaaaca ccaggaagtt ctggggagga ggaaaaaccg atgccccact 1021 tagggtgtcc catttagggt gagacggaaa atcctcacct ttttttcaca ctttaggtcc 1081 cccttcccaa aagtgagtaa gtgtgggtgc ttctgggatg agtaacagtg tcccccatta 1141 cttcatggct gactttcagc cacaggctgg aggaggcaga gggtgaccca aggccctatc 1201 taggtcaccc caatgggtca ccctaccccc tcagcctacc acatggtttt ctcctgcctg 1261 gcaccccagg gctggaggta aagcctaatt ttccgaactt cagttggggc tcccagtcta 1321 ggggggctca atttccgtct ccatattttg ttttggaatt attatttttt tgagacaggg 1381 tctcgttctg tcacccagac gggggtacag tggcatgatc atagcttact gtaacctcaa 1441 actcctgggc ttgagtgacc ctcctgcctc agcctcctga ggagctagga ttacaggcat 1501 gcaccactac acctgactaa tctttaattt tttttctaga aacaaggtct tgctatgttg 1561 cacaggctgg tcttgaacta gtgggctcaa gtggtcctcc cacctcagcc tcccaaagtg 1621 ttgggataac aggcatgagc cactgcgccc cacccttatt tgtctttgac tctctccaga 1681 agagccttca tccagggagg gggtgctttt ctctttccgg attacccacc tctcacctct 1741 cccctccttc accacaaaga ccagtgggac caagccggca tgtgagtcct tcacccacat 1801 cttattccta tgtttcattc ttttttaaaa aatagagaca ggatctcact atgttgccca 1861 ggttgctctg gaactcctgg gttcaagcga tcctctcacc ttggccttgc aaagtggtag 1921 gattacaggt gcatgccacc acgtccggca gttcggttcc ttgttcttta ttgtcctcag 1981 tctcttcgat ttcacccact gagagaatgg aaggggatag aacagctgga aactggttga 2041 aggaagccag aattcactaa gtgcccactg tgccaagggc tgagtgaggt cctctgatgg 2101 aggtcaggcc ttctctcaca tgccctatgt gtggtggaca ttcctatccc cattggatag 2161 ataggttaag tggctggttc aggttgcaga gttaggacag ggtgatttga agcctagaca 2221 cccgaatctc tggaagtccc ttggctgtgt gattcaggta cctgagaatg cggctcctct 2281 ccagctctct ccggactgct ggccagctgc aacagccgga aatctcacct gagctgcagg 2341 attttcccag caaggattgg aattcccaga gttggaaatt cccatgccct gagggagagg 2401 taattaggtt caggctct-tg tttcctgggg gatggggaat attctgttgg gctttgttta 2461 tgtagggtct ccagggccct aggagtctaa ggatgggact gggtccgagg gatcttaaag 2521 cctgtggaga gaggacttag ggagcttctt cccacccaca agaagaggca gatgcagaat 2581 taattccaag aaggagacca tgtttctttt ctaagcaaac tttatttctc gccactgaat 2641 agtagggcga ttacagacac aactccctgg ggagcagagg cctcagcaat gagtgacagt 2701 tggtcaccaa atcagcattg tttagacaac ttaatcagat aatattttaa aaaacataat 2761 caaaagaagg cacagaggcc agggggctac atgggaacag cctattgttc agcctccgtt 2821 ttcacggaaa acatgtctga gccaaggcag ctcctacatt gggtccccca ggataccccg 2881 gtctcccaaa taaatacact catctgtaaa taaataaata ataaataaat aataaataat WO 00/09525 PCT/US99/17712 EPI-109 816 2941 cacaagtgca aacataaata gagggagctg gctccatggg gagggczggg ctccgtgtct 3001 caaggaagtc tggaaacatc tggagagagg aaggcctaag gtccacztgt gtcaatttct 3061 aggtgaggtc trctcaagtc ctgcagcatt ctggccagaa ccaaaggctc cctggtctcc 3121 agattccaga tgtcagggat caaagctgta ggccccagtg agttctggag gccccagttt 3181 gaattcttag uggttgccag cacttcactg tgcaggccac acattcztga atcccaggtt 3241 tcgaagtggt ggtcttgttg cttaaagttc taagcttggg ttccgaccct aagcccccaa 3301 ttctcttttt gagccagaag aggttgaggg tgtctgaagg agggggtaat aaagggattg 3361 gggcagggga ggcgtttggg aaggttggat gttcgtcctc ctcacauggc aatgatccca 3421 aagtagacct acccagactc ggcaaagtcg agatagtcgg gccgat-gat ctcagcgctg 3481 agtcggtcac ccttctccag ctggaagacc cctcccagat agatgggctc ataccagggc 3541 ttggcctcag ccccctctgg ggtctccctc tggcaggggc tcttgatggc agagaggagg 3601 ttgaccttgg tctggtagga gacggcgatg cggctgatgg tgtgggtgag gagcacatgg 3661 gtggaggggc agccttggcc cttgaagagg acctgggagt agatgaggta caggccctct 3721 gatggcacca ccagctggtt atctctcagc tccacgccat tggccaggag ggcattggcc 3781 cggcggttca gccactggag ctgcccctca gcttgagggt ttgctggagg gagggagaga 3841 gggagaggag agtcagtgtg gccatgtcgg ttcactctcc acatcczggc cctcgagctc 3901 tgcccacccc acatccggtt cctgtcctct ctgtctgtca tcccacatcc cacctggcca 3961 tgacgttctg agtatcccac taaggcctgt gctgttcctc cacccttccc ttgagctcag 4021 cgagtccttc tcacattgtc tccaagttct gcctaccatc agccgggctt caatccccaa 4081 atcctagccc tccaagttcc aagacacatc ctcagagctc ttacctacaa catgggctac 4141 aggcttgtca ctcggggttc gagaagatga tcctgaagag gagagagaaa agaaaaagct 4201 gagaccctta aacttcctag aaaatacccc cctactttca cctccatcca tcctccccca 4261 agaccaaaac tttaaatttc ccccactgct ttccataccg gtactaaccc taccccccaa 4321 acccaaaccc agaattagga aagaggtttg gagacactta ctgactgcct gggccagagg 4381 gctgattaga gagaggtccc tggggaactg ttggggagaa ggagaatggt taacatcgag 4441 ggagtcaccc ttaaaggagg aacagctggc tgcctgtctg gcctgcgctc ttagccctga 4501 ggtgtctggt tttctctctc cattcatctg tgtattcacc ttccaggcat tcaacagctc 4561 tttccctgag tgtcttctgt gtgccagaca ccctatcttc ttctctcctt atctccccca 4621 tctctctcct tagctgtcat atttcccgct ctttctgtct caccatcttt attcatatca 4681 cttgtttctt cccccatctc tcttctcaca ccccacatct gtctccatat cttatttata 4741 tatctgcttg ttcattcatt cattcattca ttcactccat acacacttag tgagcacctt 4801 ccatgtgcca gacatcctgt ctctccatct ttctctctct ctcttcccca tctcttgcca 4861 catctctttc tgcatccccg tctttctcca cgtttttttc tctccatccc tccctatcag 4921 cgcacatctt tcacccatcc catctctctc cctctcttgc gtctccattt ccccttgggt 4981 gggagagtgg atgaaggctg gccaggcact cacctcttcc ctctgggggc cgatcactcc 5041 aaagtgcagc aggcagaaga gcgtggtggc gcctgccacg atcaggaagg agaagaggct 5101 gaggaacaag caccgcctgg agccctgggg cccccctgtc ttcttgggga gcgcctcctc 5161 ggccagctcc acgtcccgga tcatgctttc agtgctcatg gtgtcctttc caggggagag 5221 agggtggagc cgtgggtcag tatgtgagag gaagagaacc tgcctggcag cttgtcaggg 5281 gatgtggcgt ctgagggttg ttttcagggg gggtctgtag ttgcttctct ccctcttagc 5341 tggtcctctg ctgtccttgc tgagggagcg tctgctggct gggtgtgcca acaactgcct 5401 ttatatgtcc ctggggcgag aggagggcgg ggaaagaatc attcaaccag cggaaaactt 5461 ccttggtgga gaaacccatg agctcatctg gaggaagcgg tagtgggccc tgcaccttct 5521 gtctcggttt cttctccatc gcgggggcgg ggatttggaa agttggggac acacaagcat 5581 caaggatacc cctcacactc cccatcctcc ctgctccgat tccgaggggg gtcttctggg 5641 ccactgactg atttgtgtgt aggaccctgg aggctgaacc ccgtccccat gcccctcaaa 5701 acctattgcc tccatttctt ttggggacca ggtctgtggt ctgtttcctt ctaacttcca 5761 gacaggatgc aggaaaaaga tagaactaga actgggaggg gcttcagaaa gctgagtccg 5821 ttgagggaga gaaaacgggg ttggagggaa aagctgtgtt gagtcctgag gcctgtgttt 5881 gggccctgcg gggagaagga gctgggggct tggtggcagg cttgaggcct caggaaaggc 5941 tgggtgcggg tagcagggac aagcctggga cagccccggg gagtgaaatc acccccggga 6001 attcacagac cccactgggg caggccctct tctttcattc tgacccggag actcataatg 6061 cttggttcag tcttggcttc caaggaactc tggggtccct gattttzttc atgaagctct 6121 cacttctcag ggccccagtg tgtggccata tcttcttaaa cgtcccctgt attccatacc 6181 tggaggtcct ggaggctctt tcactccctg gggccctcta catggccctg tcttcgttaa 6241 gtgggggtcc ccatactcga cttccatagc cctggacatt ctcctaccca ttgctgtggt 6301 cacatctccc cagaggtctc ctgtaaccca ttcctcagag ccgctacatg tggccatatc 6361 tcccaggagc tccctgaccc ccgcccctcc agaccctgac ttttccttcg tcttctcagc 6421 ttctcctttg cttcccctgc agcagtctgg cggcctcacc tggtgagtcc atcacatatc 64 81 cctgaagctc tctgagccct tatccttttg ttctccccac agctctzgct ccctttgagc 6541 cctctgtccc tccctccatt ccttagatag actgggaagt tctcactccc agacacacac 6601 acacaagcag acagcatttc agagaaaaga ggtttattgg gcttcatcga gggtgcagat 6661 gcctccgtgt ggggctctgg tcggcagctg gctttcagag cctttccctg ccttctgggg 6721 ccctgtgatc cctcatgcct acttctttct ctcttggtca gccttgtgcg catgccctct 6781 cactcttcat ctcttgggcc tgtctctgtt tctccttgga tgttcttcta ttattcccct 6841 ctctccatcc tccataaata aataatttaa tttttttgcc ttcataaata gtcccctccc 6901 tgcctctagt catcccccaa gctcctccat gtgcctgctc ttcctczgtg tgtggatcta 6961 ggccccacct agctggtggg acagaccaac agctttgggc tgggaattcc taggcaggct WO 00/09525 PCTIUS99/17712 EPI-109 817 7021 tgaaatcctc agccaaacag acatcaggga tggttcaggg aggtgtggtc ccctgggatg 7081 cctagaatcc cttctttgaa agctccggtg acttgatcag ggaagacttg agctgttgga 7141 atgqccaaag gagaggragt gacgacccct gaaatggtca gaatggaggc agaatgggga 7201 qaaggtcttg aaatcaatta ttttttcttt ctggattttt ccaagttcta cagagcgaag 7261 gctccaaaga agacagtact agggctgagg actaggtggg ggatgccatc tgtgtgggtg 7321 gatagctggt ctccctgggt gagctggaac gcagccccgt ggtacatcga gtgcagccag 7381 ggttcctgca gccctgaata caccatcttc tgggagctga ggagaggcac atggaagggg 7441 tactgggagg agaagagctg gacctcatgg gccaggtaga gtggggagga ggtggccttg 7501 ggagagtagg ctttcccaga gaagaccacc tgggagtaga cgaagtagat gccactggtg 7561 gggaccagga gagaattatt gctcaaggag aaaccatcct ggaggaaggc acggtccgtg 7621 tttgctctcc agagcagcga gttctgcttg ctggggtctc ctaggaagag ccatagggga 7681 tgggggtggg agatcaaggg tctggatcag aggtctcaat ccctgaggaa gtgggcactg 7741 aacaactgag ttcctggggg atggcagggg gaggcatagg agtgggctcc ctctgttttt 7801 tttagcgtgg gggaagttgg gggagagggg tggatgcttg ggttcctgag gcaggggtag 7861 gaggagagct ggtggggaca tgtctgggag gtcaggtgga tgtttaccaa tgaggtgagc 7921 agcaggtttg agggtgctgt gggcaagatg catcttgggg tgctgacggg cagtctgggc 7981 agctgaaggt gtgaggccaa caccagggag cccctagggg agaacagagt tgaggggggc 8041 tctagggctc aaggtttggc tgagccaccc cagcagcccc cattctcctg ctgcctcacc 8101 tgggccccag gcagcagaac cagcagcagc cccagaagga ggaggtgtag ggtggtgcca 8161 cgcacccttg ggaggaagag acgttcaggt ggtgtcatgg ggagaacctg cagagaaaga 8221 gagagagaga gagagacagt gagcggggcg gggcacgcgg cggaagacag acctcccgcc 8281 ctgggagaca gcaccccccg acccccgaga gagagatcga cagagaaggg gacaagatgc 8341 agtcagagaa accccaaggt gagcagaggg agacagagag agacaggaag ggaacagaga 8401 ggaatcatgg cagaaacaga gaatgtgtga cagagacaat gagactgaca gatggagagt 8461 cagagacaga gaaggaaacc aaaaccaaac ccaccaaggc ccaggcccag gcaggccggg 8521 gatccaggca gcaggtgcag gagggaccga ggcccaggca gagggcagga cactgcgggg 8581 cggtagtcca aagcacaaag cacgggcagc ccaaggagat ggggcaggag agcctcacct 8641 gctgtgcgga cccctgggcc cggacgctca ggtcccttta tagaggaagc ggcagtggca 8701 gcgtggcagg cagcgggcgg gttctaggtc ggggctgggg cccggggaag cccccagggc 8761 ttagaagata ctgctgtttc agtcaaaggc aggaaaggct gaggcctagg agagaaccac 8821 aggctggggg ttcaggcgac tgagttctgg gaaagggagt cgggtcaggg gaatcgtggg 8881 ctgggagggc cagggagtgg ggtcaggcct agagttccaa agaagggaca gtcaattcag 8941 agaggaggca gttgagcagc tggggtgtga gctggaggcc cggttccctg aagagcaatc 9001 atatataaca tctctgcacc cttggctgag tacaggcttc tctctttgcc catttccttc 9061 tcttgtaccc ctgtccttgt cccaaacaac tcaaatcata cttgtcccag tatacggact 9121 ttccagccca tctggcaggt ttcacatcaa gaaggtccat tatatatccc cttcatcggg 9181 gacattctgg tgtttgcctc ttgtccaggt gaaaatatta atggatcccc cttccactct 9241 tgaaagtgtc ctcagtttgga agataaattt tttggtcccc ttactcagag atgatgctgg 9301 acagtcaagt atgatgaggt ctcatctcac tcctgaagga tgccctccat ctcttcctga 9361 cttcaggtgg cttccacaga acagatttat ataaccccaa ataaacacac attccaggat 9421 caatgtggca gacaccttcc aaagttttct acaaaggaag tttgcagaat tccacatggg 9481 tgaggcttaa gggtggtgac ttagggtggg gtggggacag ctaagggact tgttctgaag 9541 ctgcatttgc agagccata cattatttta aaattgttcc aggcctggtg cagtggctca 9601 cacctgtaat cctggcact tgggagtctg aggtgggcgg attacttgag gtcaggagtt 9661 tgagaccagc tggccaacat ggtgaaaccc catctctata ataaatacaa aaattagcca 9721 ggcgtgctgg agcgcactg cagtcccagc tactcgggag gctgaggctg gagaattatt 9781 tgaacctggg aggcggaggc tgcagtgagt caagatcgca ccactgtatt ccagcctggg 9841 ggacagagca agactctgtc tcaaaaaaaa aaaaaaagtt tccaaaatt ttttcctttt 9901 tattgatatg gaacttaggt atgaggtgga cacctcttaa gtgtacagct gatgaatttt 9961 tccatctgta tgtagccacc acccagctcc acgtattttc aggtccccag caggttccct 10021 catgccccct ccctgctgat accctccaaa gataaccaac cactctctca cttttatcac 10081 catagattat ttcctcctgg tttggggcat catataaatg aaatcacaca gaatgtactc 10141 atttctgttt gacttcttc agtcagcatt atgtttgtga gattcatata cgtggttgta 10201 tgtatcagta atgtttttta aaaaaattat gatgtaatat tctattgtat caatatattc 10261 taatatattc tgttgatggg gatttggttt gtttctagtt tttgtctaac acaaaaatgt 10321 ctacacgaac attctcatac atgagcccat ttcacttagc ttgcaagtta caaggtttaa 10381 aaaaagcagt ttctaaagat gactttattc actttccta agtttgagat aataccaact 10441 tgtcacctca aatattatta ctgctactca tgtgatttta cttggagagt gttagagggg 10501 ttggagctgg ggctggtggt gacccggggt aaagcccact gttgcatggg gcagaccact 10561 tctctcccca ggcacaaggt ccctgagggg tcttggtgta acatggaggg acatgtaagt 10621 aacattctgg gtgtgtatga gctatttctc ctgttcttct ctacttgagg acctgcccct 10681 ttgcctttta tgctttacta gtcttagcta ttatttctgt aggggcagaa aggggtgatc 10741 ccttcctgac ccatcataag ggttatggcc aatactccta taataaaaga cagattaaca 10801 agagaaaagc ataatacatt tatttaatca aagttttagg tgacatggga gccttcagaa 10861 atgaagaccc aaggacccag gggaaaacta tttttatgct tagatttgat gaagaatgaa 10921 cagctgtgca gaaatgtaat tgaacaaaag gagtatcatc taatggtcac agactgggac 10981 tggggggatc ccagcaaggc ctggccatazi cttcttggt ctctctgac agcattcctt 11041 cctcccaggt atagggcaga acctcttctg gaatgagggt cttataacct actacagat WO 00/09525 PCT/US99/17712 EPI-109 818 11101 gagataagtc agaaaatttc ttttcctttt tttttttttg agacagtttc tcactgtcgc 11161 acaggctgga gtgcagtggc acgatcttgg ctcactgcaa cctctgcctc ccaggttcaa 11221 gctattctcc tgcctcagcc tcccgagtag ctgggattac aggcacacgc caccaagccc 11281 gccaaatttt tttttgtatt tttagtagag acggggtctc accatgttgg ccaggttggt 11341 cttgaattcc tgaccacagg tgacccacca gccttggcct cccaaagtgc tgggattatg 11401 ggcgtgagcc actgcgccca accttcttct cattctttta accttattat ctcttgtgtc 11461 agtgtgggtt tcccttttag cccctgctcc tttctttttc tctgtgttgc cctttctctc 11521 agggtccttt ttgcttcctg ttgtctcttt ctgcttctct aatggtatga gctgatggac 11581 tgggacccca gctgagctat attaaaatat aaaatgttat tacaaggcca ggagcagtgg 11641 cacatgcctg tcatcccagc actttgggag gctgaggcga gcagatcaca aggtcaggag 11701 atagagacaa tcctggctaa tacggtgaaa ctccatcact gctaaaaata caaaaaatta 11761 gccgagcatg gtggcacgcg cctgtaatcc tagctactag ggaagctgag gcaggagaac 11821 tgcttgaacc caggaggcgg aggttgcagt gagccgagat cgtgccactg ccctccagcc 11881 tgggcaacaa agtgagactc catttcaaac aaaccaacca aaaaacaaaa caaaacaaaa 11941 caagcaaaca aaaaaaggta ttgcaattaa cagtgagaca cagagagaaa tttaaattaa 12001 agaggaagaa tgggacattg aaagacaaaa aagggaaggc aagaagggtg atggggagac 12061 atgagagaca cagaggaagg aagggtaaga ctgggctgag gctcagtgtc acgtgcatgt 12121 gagatatgcg aaggatgctc cttgagatgg gccaatcttg gtttcaatct cagtttcgga 12181 ggttgtatga atttggtttc tttcttggca ggccagcagt tggtttggga ctttccctgg 12241 gtgggagagc tgatgactgg agtcttgtgc cccagactca gggaaataca gtctttatag 12301 tggtctttgt ggagaaacta gtgaaatctc tgaagcctcc aaatgagact gaaatgacat 12361 tagcttcaaa cttgaactta gcctcaaaac ctgaattggg atttaatacc aacatcaacc 12421 ctaacccaaa tttaacctca acccaaatca caactcaaac tcaaccccaa ctgtaaccct 12481 aacctcaaat ctaaacacat cccaattaat aaccccctaa ataaaacttc tcctctaccc 12541 caacccaacc ctgtttctag ggctaatctt gaaaccagtt taccaccact cctaacacta 12601 aacttaaatc tgactctaaa tgtaagtcca atctgagcca caagcctaaa gttgaacttt 12661 atcctgcttt atgaattatt catccattcc tccatttagt gagtatctgc gtgcctaaca 12721 catgctgggc attgtcctaa ggcaggaggg acatggaggg caaagggatc agagaaggta 12781 ccagcacctg tggagcttgt attccagtga ggcccagacg gaaaaagaaa gaaacttgaa 12841 ggaaggaaat ttggtactat gagaaaataa gacaggctga tgttgtaaga gtggcaggga 12901 gctactttta aatacagtag tcagcaaaat cctctttgag tgtttgggtg gcactggagc 12961 tgagacccaa atgacaaaaa atagtgacca ggtaaaagtt tgggagcaaa gcatttcagg 13021 taaagggagc agctactgca aaggctggaa ggcggaacca agctgggggt gttgacgaca 13081 aacagaaggc cagtgtggct ggagcagaga gagagactgg gaggcgggtg ggagatgagg 13141 tcagagagga gggcaggggc caggtcatgc agggccatgc aagaagggta aagcctctag 13201 atttcatcca gccacaggaa gcctttaaag gtcgtcagag tgtgtggtgc gtgcgtgtgt 13261 gtgtgtgtgt gtgtgttgca ggggagagag gnggagggag agagagagag agagaagagg 13321 gaggtgagca gaggtgattg gatttttttt tcttttgaca tggtgtcttg ctctgtggcc 13381 taggctggag tgcagtggca ccatcatagc ccactgcaac ctcaaaacca tgggctcaag 13441 tcatccttcc acctcagctt cccaagtatc taggactaca ggtgtgtgcc actgtgcctg 13501 gctaatttta aaaaatattt taaaattttt gttgagacag ggtctatgct gctcaggctg 13561 gtctcgaact cctggtttca agtgatctgc ccatcttggc ctcccaaagt ttttttttgt 13621 tagtttgaga ggcggtttcg ctcgttgccc aggctggagt gcaatgactg atctcatctc 13681 actgcaacct ctgcctcctg ggttcaagcg attctcctgc ttcagcctcc caagtagctg 13741 ggattacagg tgcatgccac cattcccggc taattttttg tatttagtag agatggggtt 13801 caccatgtta gtcaggctga tctcaaactc ctgacctcag gtgatccgcc tgcctcagcc 13861 tcccaaagtt ttgggattac aggtgtgagc caccatgctg ggccagcctc ccaaagtttt 13921 gggattacag gcatgagtca ccacactggc cctggatttt ttttctttct tttttttgga 13981 gacggagtct cactctgttg cccaggctgg agtgcaatgg cgtaatctca gctcactgca 14041 acctctgctg cccgggttca aacgattctc ctgtcttagc ctcctgagta gctgggatta 14101 taggtgcatg ccaccatgcc tggctaattt ttgtactttt agtagagaaa gtacaccatc 14161 ttggccaggc tggtctcgaa ctcctgacct caggtgatcc acttgcgtcg gcctcccaaa 14221 gtgctgggat tacaggcgtg agacaccgca cccagccttt tttttttttt ttttctttta 14281 agacagaatc gctctgtcac ccaggctgga gtgcagtggc acaatctcgg ctcactgcaa 14341 cctctgcctc ccaggtttaa gcaatccacc tatgtcagtc tcccaagtag ctgggattat 14401 aggtgcatgt caccatgcct ggctaatttt tgtactttta gtatagaaag tacaccatgt 14461 tggccaggct ggtcttgaac tcctgacctc aagtgatccg cctgcctcag cctcccgaag 14521 tgctggaatt acagacatgt gccactgcac ccggcctggt tttttttttc taagagatgg 14581 agtctcactt ttctgcccag gttggagtgc aatggcacca tcatagctca ctgcagcctt 1 464 1 caactcttgg cctcaggcaa tccttgcacc ttagcctcgc aaagtgttgg gattacaggc 14701 atgagccact gagccttgcc tggacttttt tttttttttg agatggcgtc tcgctctgtt 14761 gcccaggttg gagtgctacg gcatgatctt ggctcactgc aacttccacc tcccaggttc 14821 aagcgattct cttgcctcgg ccccccgagt agctgggatt acagcatgcg ccaccgtgcc 14881 tggctaattt tggtattttt agtagagata gggtttcatc atgttgggca ggctggtctt 14941 gaactcctga cctcgtgatc cacccacctc ggcctcccaa agtgctggga ttataggcat 15001 agccaacgcg cccagcctgg acttgttttt aaaagatcac tgtggctcct gtgtttaggc 15061 tggctggtag gagacaggtg gcagtgacat tgatggtgaa gagaaaatag tggcagccat 15121 ggagatggag agaagtagac aagtttggga tatattatac attccagggg tagaaacaac WO 00/09525 PCT/US99/17712 EPI-109 819 15181 aggactagat gatggarcga tgggtgggag atgtagatac tgggagagaa gcaggattct 15241 gatggatgga aaaactaaaa aattctattt tgggtgtggt aagtctaagt ctattagaca 15301 tgcaagtaga gatgtcactg ggcagataca catctggatt tcaggggcaa ggtccaagct 15361 agagaaagaa acctgggcat ggtcagcatg aggatggtgt ttaaagccat ggaacttatc 15421 ttgtgcatcc ctataagacc cctttgaggc acttgtttcc cctcacaatg gatgcagtgc 15481 atcttccatt ctgaattcca gaggcaacaa cctcctgctc ctagaagcta aactctccag 15541 acttagtctt ctgaattccc actgggattt aacctccctg gattcaattc cctaccccac 15601 aaggaccctt ctaccaatcc atttcacaat atttggtgga actcttcaca ttttcaaatc 15661 ctgtcttcta tgtttgaaag cattttcctc tgggcatttt gaaacctggc tttcccctaa 15721 tgatgctact cctctctgtg gtgaaggttg ctctttcttc gactccatca ctaggggaat 15781 gaaggcagaa gagaggggtc gttatcccct ctcccccagg accactgata aactcctcct 15841 catctcccaa agcacgtgcc ttctggatct gccatgctct ccctgccttc acagcacaat 15901 cttatccatc aaaatattta ttatgctctt aacaacttgt ataactagct cagtctttct 15961 ccacatctta tccctaccat catccttgtt tgtttgtttt ttgagacaag gtattgctct 16021 gtcacccagg ctggagtgca gtggcgtgat cttggctcac tgcagcctcg acctcctggg 16081 ctcaagtgat cctcccacgt cagcctcctg agtagctagg actacaggcg cataccacca 16141 tgcccggcta agttttgtat tttttttttt ttccagagat agggttttgc tatgttgcct 16201 aggctggtct tgaactcctg agctcaagca atccacccgc ctcagcctcc caaagtgctg 16261 ggattacagg catgacccac cgcacccggc ctcctaccac catctttagt (2) INFORMATION FOR SEQ ID NO:2654: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: _base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2654 1 ttctccttct ccccaacagt tccccaggga cctctctcta atcagccctc tggcccaggc 61 agtcagatca tcttctcgaa ccccgagtga caagcctgta gcccatgttg tagcaaaccc 121 tcaagctgag gggcagctcc agtggctgaa ccgccgggcc aatgccctcc tggccaatgg 181 cgtggagctg agagataacc agctggtggt gccatcagag ggcctgtacc tcatctactc 241 ccaggtcctc ttcaagggcc aaggctgccc ctccacccat gtgctcctca cccacaccat 301 cagccgcatc gccgtctcct accagaccaa ggtcaacctc ctctctgcca tcaagagccc 361 ctgccagagg gagaccccag agggggctga ggccaagccc tggtatgagc ccatctatct 421 gggaggggtc ttccagctgg agaagggtga ccgactcagc gctgagatca atcggcccga 481 ctatctcgac tttgccgagt ctgggcaggt ctactttggg atcattgccc tgtgaggagg 541 acgaacatcc aaccttccca aacgcctccc ctgccccaat ccctttatta ccccctcctt 601 cagacaccct caacctcttc tggctcaaaa agagaattgg gggcttaggg tcggaaccca 661 agcttagaac tttaagcaac eagaccacca cttcgaaacc tgggattcag gaatgtgtgg 721 cctgcacagt gaattgctgg caaccactaa gaattcaaac tggggcctcc agaactcact 781 ggggcctaca gctttgatcc ctgacatctg gaatctggag accagggagc ctttggttct 841 ggccagaatg ctgcaggact tgagaagacc tcacctagaa attgacacaa gtggacctta 901 ggccttcctc tctccagatg tttccagact tccttgagac acggagccca gccctcccca 961 tggagccagc tccctctatt tatgtttgca cttgtgatta tttattattt atttattatt 1021 tatttattta cagatgaatg tatttatttg ggagaccggg gtatcctggg ggacccaatg 1081 taggagctgc cttggctcag acatgttttc cgtgaaaacg gagctgaaca ataggctgtt 1141 cccatgtagc cccctggcct ctgtgccttc ttttgattat gttttttaaa atatttatct 1201 gattaagttg tctaaacaat gctgatttgg tgaccaactg tcactcattg ctgagcctct 1261 gctccccagg ggagttgtgt ctgtaatcgc cctactattc agtggcgaga aataaagttt 1321 gctt 1 tacgggccgg gcactcccga gctgctgctc gagggcgccg agacggtgac tccagtgctg 61 gecccggcca ggagecaagg gtacgggcct ctctggtaca cgagcgtggg gttcggcggc 121 ctggtgcagc tccggagggg cgagagggtg tacgtcaaca tcagtcaccc cgatatggtg 181 gacttcgcga gagggaagac cttctttggg gccgtgatgg tggggtgagg gaatatgagt 241 gcgtggtgcg agtgcgtgaa tattgggggn ccggacgccc aggaccccat ggcagtggga 301 aaaatgtagg agactgtttg gaaattgatt ttgaacctga tgaaaataaa gaatggaaag 361 cttcagtgct gccgataaag atgctgagtt gcgacacacg tcttaattca gggtgggtgc 421 acgggtgcgg gttaaatatt ctcagtactc ttccggttgc ttgaaacaat tcatcacaac 481 acagtgtatg gcctttgctc ctagggatga tggtctgcct gtcccacccc ctccctgcct 541 ctgaatggcc aggccccacc attagcccag ttggagggtg ggaggaaggg ggacttctca 601 aactccgaag cttctctagg catcctgatt ttcagggcca catggtccca accagactct 661 gcaccatact cttttccctt gggtaccccc caacagtgag aggggtcatt acagagccca 721 gcaagcacca ctcagaaagg cccagcagca gagtaagccc ctatcatgac agaggaatga 781 agcctggagg ggccccgcac ttctccccct agagctgcct gaaggcctct ctgtctccta 841 cccgacagtc aactcttctc ctccaaggag cttaattcaa ggctcatggg gtctgaaggg 901 aggaggctga aggagaaaga aggggagaat attagagaga gatggggatg gcaggaagga 961 gcctgtggtg cctgaaaaca ccaggaagtt ctggggagga ggaaaaaccg atgccccact 1021 tagggtgtcc catttagggt gagacggaaa atcctcacct ttttttcaca ctttaggtcc 1081 cccttcccaa aagtgagtaa gtgtgggtgc ttcagggatg agtaacagtg tcccccatta WO 00/09525 PCT/US99/17712 EPI-109 820 1141 cttcatggct gactttcagc cacaggctgg aggaggcaga gggtgaccca aggccctatc 1201 taggtcaccc caatgggtca ccctaccccc tcagcctacc acatggtttt ctcctgcctg 1261 gcaccccagg gctggaggta aagcctaatt ttccgaactt cagttggggc tcccagtcta 1321 ggggggctca atttccgtct ccatattttg ttttggaatt attatttttt tgagacaggg 1381 tctcgttctg tcacccagac gggggtacag tggcatgatc atagcttact gtaacctcaa 1441 actcctgggc ttgagtgatc ctcctgcctc agcctcctga ggagctagga ttacaggcat 1501 gcaccactac acctgactaa tctttaattt tttttctaga aacaaggtct tgctatgttg 1561 cacaggctgg tcttgaacta gtgggctcaa gtggtcctcc cacctcagcc tcccaaagtg 1621 ttgggataac aggcatgagc cactgcgccc cacccttatt tgtctttgac tctctccaga 1681 agagccttca tccagggagg gggtgctttt ctctttccgg attacccacc tctcacctct 1741 cccctccttc accacaaaga ccagtgggac caagccggca tgtgagtcct tcacccacat 1801 cttattccta tgtttcattc ttttttaaaa aatagagaca ggatctcact atgttgccca 1861 ggttgctctg gaactcctgg gttcaagcga tcctctcacc ttggccttgc aaagtggtag 1921 gattacaggt gcatgccacc acgtccggca gttcggttcc ttgttcttta ttgtcctcag 1981 tctcttcgat ttcacccact gagagaatgg aaggggatag aacagctgga aactggttga 2041 aggaagccag aattcactaa gtgcccactg tgccaagggc tgagtgaggt cctctgatgg 2101 aggtcaggcc ttctctcaca tgccctatgt gtggtggaca ttcctatccc cattggatag 2161 ataggttaag tggctggttc aggttgcaga gttaggacag ggtgatttga agcctagaca 2221 cccgaatctc tggaagtccc ttggctgtgt gattcaggta cctgagaatg cggctcctct 2281 ccagctctct ccggactgct ggccagctgc aacagccgga aatctcacct gagctgcagg 2341 attttcccag caaggattgg aattcccaga gttggaaatt cccatgccct gagggagagg 2401 taattaggtt caggctcttg tttcctgggg gatggggaat attctgttgg gctttgttta 2461 tgtagggtct ccagggccct aggagtctaa ggatgggact gggtccgagg gatcttaaag 2521 cctgtggaga gaggacttag ggagcttctt cccacccaca agaagaggca gatgcagaat 2581 taattccaag aaggagacca tgtttctttt ctaagcaaac tttatttctc gccactgaat 2641 agtagggcga ttacagacac aactccctgg ggagcagagg cctcagcaat gagtgacagt 2701 tggtcaccaa atcagcattg tttagacaac ttaatcagat aatattttaa aaaacataat 2761 caaaagaagg cacagaggcc agggggctac atgggaacag cctattgttc agcctccgtt 2821 ttcacggaaa acatgtctga gccaaggcag ctcctacatt gggtccccca ggataccccg 2881 gtctcccaaa taaatacatt catctgtaaa taaataaata ataaataaat aataaataat 2941 cacaagtgca aacataaata gagggagctg gctccatggg gagggctggg ctccgtgtct 3001 caaggaagtc tggaaacatc tggagagagg aaggcctaag gtccacttgt gtcaatttct 3061 aggtgaggtc ttctcaagtc ctgcagcatt ctggccagaa ccaaaggctc cctggtctcc 3121 agattccaga tgtcagggat caaagctgta ggccccagtg agttctggag gccccagttt 3181 gaattcttag tggttgccag cacttcactg tgcaggccac acattcctga atcccaggtt 3241 tcgaagtggt ggtcttgttg cttaaagttc taagcttggg ttccgaccct aagcccccaa 3301 ttctcttttt gagccagaag aggttgaggg tgtctgaagg agggggtaat aaagggattg 3361 gggcagggga ggcgtttggg aaggttggat gttcgtcctc ctcacagggc aatgatccca 3421 aagtagacct gcccagactc ggcaaagtcg agatagtcgg gccgattgat ctcagcgctg 3481 agtcggtcac ccttctccag ctggaagacc cctcccagat agatgggctc ataccagggc 3541 ttggcctcag ccccctctgg ggtctccctc tggcaggggc tcttgatggc agagaggagg 3601 ttgaccttgg tctggtagga gacggcgatg cggctgatgg tgtgggtgag gagcacatgg 3661 gtggaggggc agccttggcc cttgaagagg acctgggagt agatgaggta caggccctct 3721 gatggcacca ccagctggtt atctctcagc tccacgccat tggccaggag ggcattggcc 3781 cggcggttca gccactggag ctgcccctca gcttgagggt ttgctggagg gagggagaga 3841 gggagaggag agtcagtgtg gccatgtcgg ttcactctcc acatcctggc cctcgagctc 3901 tgcccacccc acatccggtt cctgtcctct ctgtctgtca tcccacatcc cacctggcca 3961 tgacgttctg agtatcccac taaggcctgt gctgttcctc cacccttccc ttgagctcag 4021 cgagtccttc tcacattgtc tccaagttct gcctaccatc agccgggctt caatccccaa 4081 atcctagccc tccaagttcc aagacacatc ctcagagctc ttacctacaa catgggctac 4141 aggcttgtca ctcggggttc gagaagatga tcctgaagag gagagagaaa agaaaaagct 4201 gagaccctta aacttcctag aaaatacccc cctactttca cctccatcca tcctccccca 4261 agaccaaaac tttaaatttc ccccactgct ttccataccg gtactaaccc taccccccaa 4321 acccaaaccc agaattagga aagaggtttg gagacactta ctgactgcct gggccagagg 4381 gctgattaga gagaggtccc tggggaactg ttggggagaa ggagaatggt taacatcgag 4441 ggagtcaccc ttaaaggagg aacagctggc tgcctgtctg gcctgcgctc ttagccctga 4501 ggtgtctggt tttctctctc cattcatctg tgtattcacc ttccaggcat tcaacagctc 4561 tttccctgag tgtcttctgt gtgccagaca ccctatcttc ttctctcctt atctccccca 4621 tctctctcct tagctgtcat atttcccgct ctttctgtct caccatcttt attcatatca 4681 cttgtttctt cccccatctc tcttctcaca ccccacatct gtctccatat cttatttata 4741 tatctgcttg ttcattcatt cattcattca ttcactccat acacacttag tgagcacctt 4801 ccatgtgcca gacatcctgt ctctccatct ttctctctct ctcttcccca tctcttgcca 4861 catctctttc tgcatccccg tctttctcca cgtttttttc tctccatccc tccctatcag 4921 cgcacatctt tcacccatcc catctctctc cctctcttgc gtctccattt ccccttgggt 4981 gggagagtgg atgaaggctg gccaggcact cacctcttcc ctctgggggc cgatcactcc 5041 aaagtgcagc aggcagaaga gcgtggtggc gcctgccacg atcaggaagg agaagaggct 5101 gaggaacaag caccgcctgg agccctgggg cccccctgtc ttcttgggga gcgcctcctc 5161 ggccagctcc acgtcccgga tcatgctttc agtgctcatg gtgtcctttc caggggagag WO 00/09525 PCT/US99/17712 EPI-109 821 5221 agggtggagc cgtgga::ag tatgtgagag gaagagaacc tgcctggcag cttgtcaggg 5281 gatgtggcgt ctgagga~tg ttttcagggg gggtctgtag ttgcttctct ccctcttagc 5341 tggtcctctg ctgtcc:gc tgagggagcg tctgctggct gggtgtgcca acaactgcct 5401 ttatatgtcc ctggggcgag aggagggcgg ggaaagaatc attcaaccag cggaaaactt 5461 ccttggtgga gaaacccatg agctcatctg gaggaagcgg tagtgggccc tgcaccttct 5521 gtctcggttt cttctccatc gcgggggcgg ggatttggaa agttggggac acacaagcat 5581 caaggatacc cctcacactc cccatcctcc ctgctccgat tccgaggggg gtcttctggg 5641 ccactgactg atttgtzgt aggaccctgg aggctgaacc ccgtccccat gcccctcaaa 5701 acctattgcc tccattzctt ttggggacca ggtctgtggt ctgtttcctt ctaacttcca 5761 gacaggatgc aggaaaaaga tagaactaga actgggaggg gcttcagaaa gctgagtccg 5821 ttgagggaga gaaaacaggg ttggagggaa aagctgtgtt gagtcctgag gcctgtgttt 5881 gggccctgcg gggagaagga gctgggggct tggtggcagg cttgaggcct caggaaaggc 5941 tgggtgcggg tagcagggac aagcctggga cagccccggg gagtgaaatc acccccggga 6001 attcacagac cccactgggg caggccctct tctttcattc tgacccggag actcataatg 6061 cttggttcag tcttggcttc caaggaactc tggggtccct gatttttttc atgaagctct 6121 cacttctcag ggccccagtg tgtggccata tcttcttaaa cgtcccctgt attccatacc 6181 tggaggtcct ggaggctctt tcactccctg gggccctcta catggccctg tcttcgttaa 6241 gtgggggtcc ccatactcga cttccatagc cctggacatt ctcctaccca ttgctgtggt 6301 cacatctccc cagaggtctc ctgtaaccca ttcctcagag ccgctacatg tggccatatc 6361 tcccaggagc tccctgaccc ccgcccctcc agaccctgac ttttccttcg tcttctcagc 6421 ttctcctttg cttcccctgc agcagtctgg cggcctcacc tggtgagtcc atcacatatc 6481 cctgaagctc tctgagccct tatccttttg ttctccccac agctcttgct ccctttgagc 6541 cctctgtccc tccctccatt ccttagatag actgggaagt tctcactccc agacacacac 6601 acacaagcag acagcatttc agagaaaaga ggtttattgg gcttcatcga gggtgcagat 6661 gcctccgtgt ggggctctgg tcggcagctg gctttcagag cctttccctg ccttctgggg 6721 ccctgtgatc cctcatccct acttctttct ctcttggtca gccttgtgcg catgccctct 6781 cactcttcat ctcttgggcc tgtctctgtt tctccttgga tgttcttcta ttattcccct 6841 ctctccatcc tccataaata aataatttaa tttttttgcc ttcataaata gtcccctccc 6901 tgcctctagt catcccccaa gctcctccat gtgcctgctc ttcctctgtg tgtggatcta 6961 ggccccacct agctggtggg acagaccaac agctttgggc tgggaattcc taggcaggct 7021 tgaaatcctc agccagacag acatcaggga tggttcaggg aggtgtggtc ccctgggatg 7081 cctagaattc cttctttgaa agctccggtg acttgatcag ggaagacttg agctgttgga 7141 atggccaaag gagaggtggt gacgacccct gaaatggtca gaatggaggc agaatgggga 7201 gaaggtcttg aaatcaatta ttttttcttt ctggattttt ccaagttcta cagagcgaag 7261 gctccaaaga agacagtact agggctgagg actaggtggg ggatgccatc tgtgtgggtg 7321 gatagctggt ctccctgggt gagctggaac gcagccccgt ggtacatcga gtgcagccag 7381 ggttcctgca gccctggata caccatcttc tgggagctga ggagaggcac atggaagggg 7441 tactgggagg agaagagctg gacctcatgg gccaggtaga gtggggagga ggtggccttg 7501 ggagagtagg ctttcccaga gaagaccacc tgggagtaga cgaagtagat gccactggtg 7561 gggaccagga gagaattgtt gctcaaggag aaaccatcct ggaggaaggc acggtccgtg 7621 tttgctctcc agagcagtga gttctgcttg ctggggtctc ctaggaagag ccatagggga 7681 tgggggtggg agatcagggg tctggatcag aggtctcaat ccctgaggaa gtgggcactg 7741 aacaactgag ttcctggggg atggcagggg gaggcatagg agtgggctcc ctctgttttt 7801 tttagcgtgg gggaagtgg gggagagggg tggatgcttg ggttcctgag gcaggggtag 7861 gaggagagct ggtggggaca tgtctgggag gtcaggtgga tgtttaccaa tgaggtgagc 7921 agcaggtttg agggtgctgt gggcaagatg catcttgggg tgctgacggg cagtctgggc 7981 agctgaaggt gtgaggccaa caccagggag cccctagggg agaacagagt tgaggggggc 8041 tctagggctc aaggttggc tgagccaccc cagcagcccc cattctcctg ctgcctcacc 8101 tgggccccag gcagcagaac cagcagcagc cccagaagga ggaggtgtag ggtggtgcca 8161 cgcacccttg ggaggaagag acgttcaggt ggtgtcatgg ggagaacctg cagagaaaga 8221 gagagagaga gagagacagt gagcggggcg gggcacgcgg cggaagacag acctcccgcc 8281 ctgggagaca gcaccccccg acccccgaga gagagatcga cagagaaggg gacaagatgc 8341 agtcagagaa accccaaggt gagcagaggg agacagagag agacaggaag ggaacagaga 8401 ggaatcatgg cagaaacaga gaatgtgtga cagagacaat gagactgaca gatggagagt 8461 cagagacaga gaaggaaacc aaaaccaaac ccaccaaggc ccaggcccag gcaggccggg 8521 gatccaggca gcaggtgcag gagggaccga ggcccaggca gagggcagga cactgcgggg 8581 cggtagtcca aagcacgaag cacgggcagc ccaaggagat ggggcaggag agcctcacct 8641 gctgtgcgga cccctgggcc cggacgctca ggtcccttta tagaggaagc ggcagtggca 8701 gcgtggcagg cagcgggcgg gttctaggtc ggggctgggg cccggggaag cccccagggc 8761 ttagaagata ctgctgtttc agtcaaaggc aggaaaggct gaggcctagg agagaaccac 8821 aggctggggg ttcaggcgac tgagttctgg gaaagggagt cgggtcaggg gaatcgtggg 8881 ctgggagggc cagggagtgg ggtcaggcct agagttccaa agaagggaca gtcaattcag 8941 agaggaggca gttgagcagc tggggtgtga gctggaggcc cggttccctg aagagcaatc 9001 atatataaca tctctgcacc cttggctgag tacaggcttc tctctttgcc catttccttc 9061 tcttgtaccc ctgtccttgt cccaaacaac tcaaatcata cttgtcccag tatacggact 9121 ttccagccca tctggcaggt ttcacatcaa gaaggtccat tatatatccc cttcatcggg 9181 gacattctgg tgtttgcctc ttgtccaggt gaaaatatta atggatcccc cttccactct 9241 tgaaagtgtc ctagtttgga agataaattt tttggtcccc ttactcagag atgatgctgg WO 00/09525 PCT/US99/17712 EPI-109 822 9301 acagtcaagt atgatgaagt ctcatctcac tcctgaagga tgcccrocat ctcttcctga 9361 cttcaggtgg cttccacaga acagatttat ataaccccaa ataaacacac attccaggat 9421 caatgtggca gacaccttcc aaagttttct acaaaggaag tttgcagaat tccacatggg 9481 tgaggcttaa gggtggtgac ttagggtggg gtggggacag ctaagggact tgttctgaag 9541 ctgcatttgc agagccaata cattatttta aaattgttcc aggcctggtg cagtggctca 9601 cacctgtaat cctggcactt tgggagtctg aggtgggcgg attacttgag gtcaggagtt 9661 tgagaccagc tggccaacat ggtgaaaccc catctctata ataaatacaa aaattagcca 9721 ggcgtgctgg tgcgcatctg cagtcccagc tactcgggag gctgaggctg gagaattatt 9781 tgaacctggg aggcggaggc tgcagtgagt caagatcgca ccactgratt ccagcctggg 9841 ggacagagca agactc:gtc tcaaaaaaaa aaaaaaagtt tccaaaattt ttttcctttt 9901 tattgatatg taacttaggt ataaggtgga cacctcttaa gtgtacagct gatgaatttt 9961 tccatctgta tgtagccacc acccagctcc acgtattttc aggtccccag caggttccct 10021 catgccccct ccctgctgat accctccaaa gataaccaac cactctctca cttttatcac 10081 catagattat ttcctcctgg tttggggcat catataaatg aaatcacaca gaatgtactc 10141 atttctgttt gacttctttc agtcagcatt atgtttgtga gattcatata cgtggttgta 10201 tgtatcagta atgtttttta aaaaaattat gatgtaatat tctattgtat caatatattc 10261 taatatattc tgttgatagg gatttggttt gtttctagtt tttgtctaac acaaaaatgt 10321 ctacacgaac attctcatac atgagcccat ttcacttagc ttgcaagtta caaggtttaa 10381 aaaaagcagt ttctaaaaat gactttattc acttttccta agtttgagat aataccaact 10441 tgtcacctca aatattatta ctgctactca tgtgatttta cttggagagt gttagagggg 10501 ttggagctgg ggctggtggt gacccggggt aaagcccact gttgcatggg gcagaccact 10561 tctctcccca ggcacaaggt ccctgagggg tcttggtgta acatggaggg acatgtaagt 10621 aacattctgg gtgtgtatga gctatttctc ctgttcttct ctacttgagg acctgcccct 10681 ttgcctttta tgctttacta gtcttagcta ttatttctgt aggggcagaa aggggtgatc 10741 ccttcctgac ccatcataag ggttatggcc aatactccta taataaaaga cagattaaca 10801 agagaaaagc ataatacatt tatttaatca aagttttagg tgacatggga gccttcagaa 10861 atgaagaccc aaggacccag gggaaaacta tttttatgct tagatttgat gaagaatgaa 10921 cagctgtgca gaaatgtaat tgaacaaaag gagtatcatc taatggtcac agactgggac 10981 tggggggatc ccagcaaggc ctggccatat tcttcttggt ctctctgtac agcattcctt 11041 cctcccaggt atagggcaga acctcttctg gaatgagggt cttataacct actatcagat 11101 gagataagtc agaaaatttc ttttcctttt tttttttttg agacagtttc tcactgtcgc 11161 acaggctgga gtgcagtggc acgatcttgg ctcactgcaa cctctgcctc ccaggttcaa 11221 gctattctcc tgcctcagcc tcccgagtag ctgggattac aggcacacgc caccaagccc 11281 gccaaatttt tttttgtatt tttagtagag acggggtctc accatgttgg ccaggttggt 11341 cttgaattcc tgaccacagg tgacccacca gccttggcct cccaaagtgc tgggattatg 11401 ggcgtgagcc actgcgccca accttcttct cattctttta accttattat ctcttgtgtc 11461 agtgtgggtt tcccttttag cccctgctcc tttctttttc tctgtgttgc cctttctctc 11521 agggtccttt ttgcttcctg ttgtctcttt ctgcttctct aatggtatga gctgatggac 11581 tgggacccca gctgagctat attaaaatat aaaatgttat tacaaggcca ggagcagtgg 11641 cacatgcctg tcatcccagc actttgggag gctgaggcga gcagarcaca aggtcaggag 11701 atagagacaa tcctggctaa tacggtgaaa ctccatcact gctaaaaata caaaaaatta 11761 gccgagcatg gtggcacgcg cctgtaatcc tagctactag ggaagctgag gcaggagaac 11821 tgcttgaacc caggaggcgg aggttgcagt gagccgagat cgtgccactg ccctccagcc 11881 tgggcaacaa agtgagactc catttcaaac aaaccaacca aaaaacaaaa caaaacaaaa 11941 caagcaaaca aaaaaaggta ttgcaattaa cagtgagaca cagagagaaa tttaaattaa 12001 agaggaagaa tgggacattg aaagacaaaa aagggaaggc aagaagggtg atggggagac 12061 atgagagaca cagaggaagg aagggtaaga ctgggctgag gctcagtgtc acgtgcatgt 12121 gagatatgcg aaggatgctc cttgagatgg gccaatcttg gtttcaatct cagtttcgga 12181 ggttgtatga atttggtttc tttcttggca ggccagcagt tggtttggga ctttccctgg 12241 gtgggagagc tgatgactgg agtcttgtgc cccagactca gggaaataca gtctttatag 12301 tggtctttgt ggagaaacta gtgaaatctc tgaagcctcc aaatgagact gaaatgacat 12361 tagcttcaaa cttgaactta gcctcaaaac ctgaattggg atttaatacc aacatcaacc 12421 ctaacccaaa tttaacctca acccaaatca caactcaaac tcaaccccaa ctgtaaccct 12481 aacctcaaat ctaaacacat cccaattaat aaccccctaa ataaaacttc tcctctaccc 12541 caacccaacc ctgtttctag ggctaatctt gaaaccagtt taccaccact cctaacacta 12601 aacttaaatc tgactctaaa tgtaagtcca atctgagcca caagcctaaa gttgaacttt 12661 atcctgcttt atgaattatt catccattcc tccatttagt gagtatctgc gtgcctaaca 12721 catgctgggc attgtcctaa ggcaggaggg acatggaggg caaagggatc agagaaggta 12781 ccagcacctg tggagcttgt attccagtga ggcccagacg gaaaaagaaa gaaacttgaa 12841 ggaaggaaat ttggtaczat gagaaaataa gacaggctga tgttgtaaga gtggcaggga 12901 gctactttta aatacagtag tcagcaaaat cctctttgag tgtttgggtg gcactggagc 12961 tgagacccaa atgacaaaaa atagtgacca ggtaaaagtt tgggagcaaa gcatttcagg 13021 taaagggagc agctactgca aaggctggaa ggcggaacca agctgggggt gttgacgaca 13081 aacagaaggc cagtgtggct ggagcagaga gagagactgg gaggcgggtg ggagatgagg 13141 tcagagagga gggcaggggc caggtcatgc agggccatgc aagaagggta aagcctctag 13201 atttcatcca gccacaggaa gcctttaaag gtcgtcagag tgtgtggtgc gtgcgtgtgt 13261 gtgtgtgtgt gtgtgttgca ggggagagag gnggagggag agagagagag agagaagagg 13321 gaggtgagca gaggtgattg gatttttttt tcttttgaca tggtgtcttg ctctgtggcc WO 00/09525 PCT/US99/17712 EPI-109 823 13381 taggctggag tgcagtggca ccatcatagc ccactgcaac ctcaaaacca tgggctcaag 13441 tcatccttcc acctcagctt cccaagtatc taggactaca ggtgtgtgcc actgtgcctg 13501 gctaatttta aaaaatattt taaaattttt gttgagacag ggtctargct gctcaggctg 13561 gtctcgaact cctggtttca agtgatctgc ccatcttggc ctcccaaagt ttttttttgt 13621 tagtttgaga ggcggtttcg ctcgttgccc aggctggagt gcaatgactg atctcatctc 13681 actgcaacct ctgcctcctg ggttcaagcg attctcctgc ttcagcctcc caagtagctg 13741 ggattacagg tgcatgccac cattcccggc taattttttg tatttagtag agatggggtt 13801 caccatgtta gtcaggctga tctcaaactc ctgacctcag gtgatccgcc tgcctcagcc 13861 tcccaaagtt ttgggattac aggtgtgagc caccatgctg ggccagcctc ccaaagtttt 13921 gggattacag gcatgagtca ccacactggc cctggatttt ttttctttct tttttttgga 13981 gacggagtct cactctgttg cccaggctgg agtgcaatgg cgtaatctca gctcactgca 14041 acctctgctg cccgggttca aacgattctc ctgtcttagc ctcctgagta gctgggatta 14101 taggtgcatg ccaccatgcc tggctaattt ttgtactttt agtagagaaa gtacaccatc 14161 ttggccaggc tggtctcgaa ctcctgacct caggtgatcc acttgcgtcg gcctcccaaa 14221 gtgctgggat tacaggcgtg agacaccgca cccagccttt tttttttttt ttttctttta 14281 agacagaatc gctctgtcac ccaggctgga gtgcagtggc acaatctcgg ctcactgcaa 14341 cctctgcctc ccaggtttaa gcaatccacc tatgtcagtc tcccaagtag ctgggattat 14401 aggtgcatgt caccatgcct ggctaatttt tgtactttta gtatagaaag tacaccatgt 14461 tggccaggct ggtcttgaac tcctgacctc aagtgatccg cctgcctcag cctcccgaag 14521 tgctggaatt acagacatgt gccactgcac ccggcctggt tttttttttc taagagatgg 14581 agtctcactt ttctgcccag gttggagtgc aatggcacca tcatagctca ctgcagcctt 14641 caactcttgg cctcaggcaa tccttgcacc ttagcctcgc aaagtgttgg gattacaggc 14701 atgagccact gagccttgcc tggacttttt tttttttttg agatggcgtc tcgctctgtt 14761 gcccaggttg gagtgctacg gcatgatctt ggctcactgc aacttccacc tcccaggttc 14821 aagcgattct cttgcctcgg ccccccgagt agctgggatt acagcargcg ccaccgtgcc 14881 tggctaattt tggtattttt agtagagata gggtttcatc atgttgggca ggctggtctt 14941 gaactcctga cctcgtgatc cacccacctc ggcctcccaa agtgctggga ttataggcat 15001 agccaacgcg cccagcctgg acttgttttt aaaagatcac tgtggctcct gtgtttaggc 15061 tggctggtag gagacaggtg gcagtgacat tgatggtgaa gagaaaatag tggcagccat 15121 ggagatggag agaagtagac aagtttggga tatattatac attccagggg tagaaacaac 15181 aggactagat gatggattga tgggtgggag atgtagatac tgggagagaa gcaggattct 15241 gatggatgga aaaactaaaa aattctattt tgggtgtggt aagtctaagt ctattagaca 15301 tgcaagtaga gatgtcactg ggcagataca catctggatt tcaggggcaa ggtccaagct 15361 agagaaagaa acctgggcat ggtcagcatg aggatggtgt ttaaagccat ggaacttatc 15421 ttgtgcatcc ctataagacc cctttgaggc acttgtttcc cctcacaatg gatgcagtgc 15481 atcttccatt ctgaattcca gaggcaacaa cctcctgctc ctagaagcta aactctccag 15541 acttagtctt ctgaattccc actgggattt aacctccctg gattcaattc cctaccccac 15601 aaggaccctt ctaccaatcc atttcacaat atttggtgga actcttcaca ttttcaaatc 15661 ctgtcttcta tgtttgaaag cattttcctc tgggcatttt gaaacctggc tttcccctaa 15721 tgatgctact cctctctgtg gtgaaggttg ctctttcttc gactccatca ctaggggaat 15781 gaaggcagaa gagaggggtc gttatcccct ctcccccagg accactgata aactcctcct 15841 catctcccaa agcacgtgcc ttctggatct gccatgctct ccctgccttc acagcacaat 15901 cttatccatc aaaatattta ttatgctctt aacaacttgt ataactagct cagtctttct 15961 ccacatctta tccctaccat catccttgtt tgtttgtttt ttgagacaag gtattgctct 16021 gtcacccagg ctggagtgca gtggcgtgat cttggctcac tgcagcctcg acctcctggg 16081 ctcaagtgat cctcccacgt cagcctcctg agtagctagg actacaggcg cataccacca 16141 tgcccggcta agttttgtat tttttttttt ttccagagat agggttttgc tatgttgcct 16201 aggctggtct tgaactcctg agctcaagca atccacccgc ctcagcctcc caaagtgctg 16261 ggattacagg catgacccac cgcacccggc ctcctaccac catctttagt (2) INFORMATION FOR SEQ ID NO:2655: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2655 1 aattcgataa ttcaaaatga tatttcagtg gggacaaggc caaaccatat tatgtgcttt 61. atgctactaa taaaaaggtt aaaccgaaca agttcaaaga caaaactcag tagtacttta 121 ttcagacagg ttagtctaaa tctgttaacc ttatacttgc aactctgatc attcattaat 181 tctgcaaatt ttaataaatg ctttatttta agctaaatgc tgagatgaaa aaatgaaacc 241 atatgagtta gcaaagtaga aaatataggc atattaatca gtaaatgcag aatgataaat 301 gctccatcaa tatgcacttg ttgtagtgag gccaccgagg agggtgcaat cctctcaacc 361 tgggaggagc aggtaggact tcagatgtca tccaactcaa agatatagtg agggacttga 421 tcaaacattt gccaagacca ctatgagtta aatgaataga ttaggcattt ctccaatgtt 481 gcaagcttcg aatcatatcc aaactcagaa caacatagct tggtcataat gatcccaagg 541 atcctattgg ccattgtctt tgagcctcaa aggaacatat taaaactcca taataccctt 601 ttgatctatt ctgaagttaa gtagtgaatt tacacgatga tgacacaaac actgtaaagg WO 00/09525 PCT/US99/17712 EPI-109 824 661 acctctgggt tacttgttta taagctagta tttcctgaat caatttttct gatccctaga 721 tatttggtag gtgaagtcat acctatatat ccccacaccc tagaacagca tctccaactt 781 ttttttccct ccttgtcttt tagtgggagc cacatcagta tccaaggagg agatccagaa 841 gcctctccaa ccaggtaggg acagttatag attccagacc tcagctatgg cctttgttac 901 agagtacaaa tgttatatag tacaagttta ttgtacacat cccattgagt ctctgagctt 961 tagaattttc ttgtagaatt taacagtttt ttcatgccgt atttacatat tattgctagt 1021 atttagaatt -tcttczcca aatgtataac gtttattatt gcattttttg tatccactaa 1081 gtggaaaatc atgcattaga tattgtagaa gtagatacaa caatgaacaa gaactggtcc 1141 tgaccatgag aggaactgat gatccaatgg gggagataga cctgcacgtg tttaataaaa 1201 ggaagtggct attccggttt ctttttgatg ggcaagcatt ttgcaaggcc ttgggctatg 1261 tgtgtgcaag gctaagccag ttagttaatt gggatttttt taaaaaggca cttcactggg 1321 gggaaaagga acatagagtt ggttattgtc cccttgccta taataaaaac ctattatttt 1381 taatttttta actgggtttg cggttaaatc tcacagccca agagatttgc cacttcagat 1441 ggattccata cacttgcatt taagtatgca aaaaaattcc aattatccag caatttaacc 1501 aaattattgg taacttttct aaaacaaaaa aaaattgttt cccttgtttt ggcagcaatt 1561 tcagttacag tcctttactt tctactcaag aaaatagttt caaaaagttg atgtttgttg 1621 ctaaaagaac tatttttatg aataaatata aaactaagaa gttatggtgt ccctttttta 1681 aaaaatgact catcaaaaga aataactttt tcctttctct tgtaagagaa aaaaattaat 1741 ctcttttaga attgcaaaca tatttccttg atggagaaaa tcaattcaca tggcatagtc 1801 gttatttatc cagttcaaaa accagagtag aatttactac tctgtctcca ttttttctct 1861 ccccaccccc ttaacccaca ttggattcag aaagcttcat tctgcaatca gcattgtcct 1921 ttatctttcc agtaaagata gccttttgga gtcgaagatg aqgaaaagcc tqtattttat 1981 agtcttggaa gtgtcttctt ttgccaggac agagagagga gcttcagcag tgagagcaac 2041 tgaaggggtt aatagtggaa cttggctggg tgtctgttaa acttttttcc ctggctctgc 2101 cctgggtttc cccttgaagg gatttccctc cgcctctgca acaagaccct ttataaagca 2161 cagactttct atttcactcc gcggtatctg catcgggcct cactggcttc aggagctgaa 2221 taccctccca ggcacacaca ggtgggacac aaataagggt tttggaacca ctattttctc 2281 atcacgacag caacttaaaa tgcctgggaa gatggtcgtg atccttggag cctcaaatat 2341 actttggata atgtttgcag cttgtaagtt atttcccttc atctgtttca aatgtt (2) INFORMATION FOR SEQ ID NO:2656: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: _base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2656 1 atgcctggga agatggtcgt gatccttgga gcctcaaata tactttggat aatgtttgca 61 gcttctcaag cttttaaaat cgagaccacc ccagaatcta gatatcttgc tcagattggt 121 gactccgtct cattgacttg cagcaccaca ggctgtgagt ccccattttt ctcttggaga 181 acccagatag atagtccact gaatgggaag gtgacgaatg aggggaccac atctacgctg 241 acaatgaatc ctgttagttt tgggaacgaa cactcttacc tgtgcacagc aacttgtgaa 301 tctaggaaat tggaaaaagg aatccaggtg gagatctact cttttcctaa ggatccagag 361 attcatttga gtggccctct ggaggctggg aagccgatca cagtcaagtg ttcagttgct 421 gatgtatacc catttgacag gctggagata gacttactga aaggagatca tctcatgaag 481 agtcaggaat ttctggagga tgcagacagg aagtccctgg aaaccaagag tttggaagta 541 acctttactc ctgtcattga ggatattgga aaagttcttg tttgccgagc taaattacac 601 attgatgaaa tggattctgt gcccacagta aggcaggctg taaaagaatt gcaagtctac 661 atatcaccca agaatacagt tatttctgtg aatccatcca caaagctgca agaaggtggc 721 tctgtgacca tgacctgttc cagcgagggt ctaccagctc cagagatttt ctggagtaag 781 aaattagata atgggaatct acagcacctt tctggaaatg caactctcac cttaattgct 841 atgaggatgg aagattctgg aatttatgtg tgtgaaggag ttaatttgat tgggaaaaac 901 agaaaagagg tggaattaat tgttcaagag aaaccattta ctgttgagat ctcccctgga 961 ccccggattg ctgctcagat tggagactca gtcatgttga catgtagtgt catgggctgt 1021 gaatccccat ctttctcctg gagaacccag atagacagcc ctctgagcgg gaaggtgagg 1081 agtgagggga ccaattccac gctgaccctg agccctgtga gttttgagaa cgaacactct 1141 tatctgtgca cagtgacttg tggacataag aaactggaaa agggaatcca ggtggagctc 1201 tactcattcc ctagagatcc agaaatcgag atgagtggtg gcctcgtgaa tgggagctct 1261 gtcactgtaa gctgcaaggt tcctagcgtg tacccccttg accggctgga gattgaatta 1321 cttaaggggg agactattct ggagaatata gagtttttgg aggatacgga tatgaaatct 1381 ctagagaaca aaagtttgga aatgaccttc atccctacca ttgaagatac tggaaaagct 1441 cttgtttgtc aggctaagtt acatattgat gacatggaat tcgaacccaa acaaaggcag 1501 agtacgcaaa cactttatgt caatgttgcc cccagagata caaccgtctt ggtcagccct 1561 tcctccatcc tggaggaagg cagttctgtg aatatgacat gcttgagcca gggctttcct 1621 gctccgaaaa tcctgtggag caggcagctc cctaacgggg agctacagcc tctttctgag 1681 aatgcaactc tcaccttaat ttctacaaaa atggaagatt ctggggttta tttatgtgaa 1741 ggaattaacc aggctggaag aagcagaaag gaagtggaat taattatcca agtactcca 1801 aaagacataa aacttacagc ttttccttct gagagtgtca aagaaggaga cactgtcatc 1861 atctcttgca catgtggaaa tgttccagaa acatggataa tcctgaagaa aaaagcggag WO 00/09525 PCT/US99/17712 EPI-109 825 1921 acaggagaca cagtaczaaa atctatagat ggcgcctata ccatccgaaa ggcccagttg 1981 aaggatgcgg gagtatatga atgtgaatct aaaaacaaag ttggctcaca attaagaagt 2041 ttaacacttg atgttcaagg aagagaaaac aacaaagact atttttctcc tgagcttctc 2101 gtgctctatt ttgcatcctc cttaataata cctgccattg gaatgataat ttactttgca 2161 agaaaagcca acatgaaggg gtcatatagt cttgtagaag cacagaaatc aaaagtgtag (2) INFORMATION FOR SEQ ID NO:2657: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2657 1 aattcgataa ttcaaaatga tatttcagtg gggacaaggc caaaccatat tatgtgcttt 61 atgctactaa taaaaaggtt aaaccgaaca agttcaaaga caaaactcag tagtacttta 121 ttcagacagg ttagtctaaa tctgttaacc ttatacttgc aactctgatc attcattaat 181 tctgcaaatt ttaataaatg ctttatttta agctaaatgc tgagatgaaa aaatgaaacc 241 atatgagtta gcaaagtaga aaatataggc atattaatca gtaaatgcag aatgataaat 301 gctccatcaa tatgcacttg ttgtagtgag gccaccgagg agggtgcaat cctctcaacc 361 tgggaggagc aggtaggact tcagatgtca tccaactcaa agatatagtg agggacttga 421 tcaaacattt gccaagacca ctatgagtta aatgaataga ttaggcattt ctccaatgtt 481 gcaagcttcg aatcatatcc aaactcagaa caacatagct tggtcataat gatcccaagg 541 atcctattgg ccattgtctt tgagcctcaa aggaacatat taaaactcca taataccctt 601 ttgatctatt ctgaagttaa gtagtgaatt tacatgatga tgacacaaac actgtaaagg 661 acctctgggt tacttgttta taagctagta tttcctgaat caatttttct gatccctaga 721 tatttggtag gtgaagtcat acctatatat ccccacaccc tagaacagca tctccaactt 781 ttttttccct ccttgtcttt tagtgggagc cacatcagta tccaaggagg agatccagaa 841 gcctctccaa ccaggtaggg acagttatag attccagacc tcagctatgg cctttgttac 901 agagtacaaa tgttatatag tacaagttta ttgtacacat cccattgagt ctctgagctt 961 tagaattttc ttgtagaatt taacagtttt ttcatgccgt atttacatat tattgctagt 1021 atttagaatt ttcttctcca aatgtataac gtttattatt gcattttttg tatccactaa 1081 gtggaaaatc atgcattaga tattgtagaa gtagatacaa caatgaacaa gaactggtcc 1141 tgaccatgag aggaactgat gatccaatgg gggagataga cctgcacgtg tttaataaaa 1201 ggaagtggct attccggttt ctttttgatg ggcaagcatt ttgcaaggcc ttgggctatg 1261 tgtgtgcaag gctaagccag ttagttaatt gggatttttt taaaaaggca cttcactggg 1321 gggaaaagga acatagagtt ggttattgtc cccttgccta taataaaaac ctattatttt 1381 taatttttta actgggtttg cggttaaatc tcacagccca agagatttgc cacttcagat 1441 ggattccata cacttgcatt taagtatgca aaaaaattcc aattatccag caatttaacc 1501 aaattattgg taacttttct aaaacaaaaa aaaattgttt cccttgtttt ggcagcaatt 1561 tcagttacag tcctttactt tctactcaag aaaatagttt caaaaagttg atgtttgttg 1621 ctaaaagaac tatttttatg aataaatata aaactaagaa gttatggtgt ccctttttta 1681 aaaaatgact catcaaaaga aataactttt tcctttctct tgtaagagaa aaaaattaat 1741 ctcttttaga attgcaaaca tatttccttg atggagaaaa tcaattcaca tggcatagtc 1801 gttatttatc cagttcaaaa accagagtag aatttactac tctgtctcca ttttttctct 1861 ccccaccccc ttaacccaca ttggattcag aaagcttcat tctgcaatca gcattgtcct 1921 ttatctttcc agtaaagata gccttttgga gtcgaagatg aggaaaagcc tgtattttat 1981 agtcttggaa gtgtcttctt ttgccaggac agagagagga gcttcagcag tgagagcaac 2041 tgaaggggtt aatagtggaa cttggctggg tgtctgttaa acttttttcc ctggctctgc 2101 cctgggtttc cccttgaagg gatttccctc cgcctctgca acaagaccct ttataaagca 2161 cagactttct atttcactcc gcggtatctg catcgggcct cactggcttc aggagctgaa 2221 taccctccca ggcacacaca ggtgggacac aaataagggt tttggaacca ctattttctc 2281 atcacgacag caacttaaaa tgcctgggaa gatggtcgtg atccttggag cctcaaatat 2341 actttggata atgtttgcag cttgtaagtt atttcccttc atctgtttca aatgtt 1 atgcctggga agatggtcgt gatccttgga gcctcaaata tactttggat aatgtttgca 61 gcttctcaag cttttaaaat cgagaccacc ccagaatcta gatatcttgc tcagattggt 121 gactccgtct cattgacttg cagcaccaca ggctgtgagt ccccattttt ctcttggaga 181 acccagatag atagtccact gaatgggaag gtgacgaatg aggggaccac atctacgctg 241 acaatgaatc ctgttagttt tgggaacgaa cactcttacc tgtgcacagc aacttgtgaa 301 tctaggaaat tggaaaaagg aatccaggtg gagatctact cttttcctaa ggatccagag 361 attcatttga gtggccctct ggaggctggg aagccgatca cagtcaagtg ttcagttgct 421 gatgtatacc catttgacag gctggagata gacttactga aaggagatca tctcatgaag 481 agtcaggaat ttctggagga tgcagacagg aagtccctgg aaaccaagag tttggaagta 541 acctttactc ctgtcattga ggatattgga aaagttcttg tttgccgagc taaattacac 601 attgatgaaa tggattctgt gcccacagta aggcaggctg taaaagaatt gcaagtctac 661 atatcaccca agaatacagt tatttctgtg aatccatcca caaagctgca agaaggtggc 721 tctgtgacca tgacctgttc cagcgagggt caccagctc cagagatttt ctggagtaag 781 aaattagata atgggaatct acagcacctt tctggaaatg caactctcac cttaattgct 841 atgaggatgg aagattctgg aatttatgtg tgtgaaggag ttaatttgat tgggaaaaac 901 agaaaagagg tggaattaat tgttcaagag aaaccattta ctgttgagat ctcccctgga WO 00/09525 PCT/US99/17712 EPI-109 826 961 ccccggattg ctgctcaaat tggagactca gtcatgttga catgtagtgt catgggctgt 1021 gaatccccat ctttctcctg gagaacccag atagacagcc ctctgagcgg gaaggtgagg 1081 agtgagggga ccaattccac gctgaccctg agccctgtga gttttgagaa cgaacactct 1141 tatctgtgca cagtgacttg tggacataag aaactggaaa agggaatcca ggtggagctc 1201 tactcattcc ctagagatcc agaaatcgag atgagtggtg gcctcgtgaa tgggagctct 1261 gtcactgtaa gctgcaaggt tcctagcgtg tacccccttg accggctgga gattgaatta 1321 cttaaggggg agactattct ggagaatata gagtttttgg aggatacgga tatgaaatct 1381 ctagagaaca aaagtttgga aatgaccttc atccctacca ttgaagatac tggaaaagct 1441 cttgtttgtc aggctaagtt acatattgat gacatggaat tcgaacccaa acaaaggcag 1501 agtacgcaaa cactttatgt caatgttgcc cccagagata caaccgtctt ggtcagccct 1561 tcctccatcc tggaggaagg cagttctgtg aatatgacat gcttgagcca gggctttcct 1621 gctccgaaaa tcctgtggag caggcagctc cctaacgggg agctacagcc tctttctgag 1681 aatgcaactc tcaccttaat ttctacaaaa atggaagatt ctggggttta tttatgtgaa 1741 ggaattaacc aggctggaag aagcagaaag gaagtggaat taattatcca agttactcca 1801 aaagacataa aacttacagc ttttccttct gagagtgtca aagaaggaga cactgtcatc 1861 atctcttgta catgtggaaa tgttccagaa acatggataa tcctgaagaa aaaagcggag 1921 acaggagaca cagtactaaa atctatagat ggcgcctata ccatccgaaa ggcccagttg 1981 aaggatgcgg gagtatatga atgtgaatct aaaaacaaag ttggctcaca attaagaagt 2041 ttaacacttg atgttcaagg aagagaaaac aacaaagact atttttctcc tgagcttctc 2101 gtgctctatt ttgcatcctc cttaataata cctgccattg gaatgataat ttactttgca 2161 agaaaagcca acatgaaggg gtcatatagt cttgtagaag cacagaaatc aaaagtgtag (2) INFORMATION FOR SEQ ID NO:2658: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: _base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2658 1 gcaggaacag tgctagtatt gctcgagccc gagggctgga ggttagggga tgaaggtctg 61 cttccacgct ttgcactgaa ttagggctag aattggggat gggggtaggg gcgcattcct 121 tcgggagccg aggcttaagt cctcggggtc ctgtactcga tgccgtttct cctatctctg 181 agcctcagaa ctgtcttcag tttccgtaca agggtaaaaa ggcgctctct gccccatccc 241 ccccgacctc gggaacaagg gtccgcattg aaccaggtgc gaatgttctc tctcattctg 301 cgccgttccc gcctcccctc ccccagccgc ggcccccgcc tccccccgca ctgcaccctc 361 ggtgttggct gcagcccgcg agcagttccc gtcaatccct ccccccttac acaggatgtc 421 catattagga catctgcgtc agcaggtttc cacggccttt ccctgtagcc ctggggggag 481 ccatccccga aacccctcat cttggggggc ccacgagacc tctgagacag gaactgcgaa 541 atgctcacga gattaggaca cgcgccaagg cgggggcagg gagctgcgag cgctggggac 601 gcagccgggc ggccgcagaa gcgcccaggc ccgcgcgcca cccctctggc gccaccgtgg 661 ttgagcccgt gacgtttaca ctcattcata aaacgcttgt tataaaagca gtggctgcgg 721 cgcctcgtac tccaaccgca tctgcagcga gcaactgaga agccaagact gagccggcgg 781 ccgcggcgca gcgaacgagc agtgaccgtg ctcctaccca gctctgcttc acagcgccca 841 cctgtctccg cccctcggcc cctcgcccgg ctttgcctaa ccgccacgat gatgttctcg 901 ggcttcaacg cagactacga ggcgtcatcc tcccgctgca gcagcgcgtc cccggccggg 961 gatagcctct cttactacca ctcacccgca gactccttct ccagcatggg ctcgcctgtc 1021 aacgcgcagg taaggctggc ttcccgtcgc cgcggggccg ggggcttggg gtcgcggagg 1081 aggagacacc gggcgggacg ctccagtaga tgagtagggg gctcccttgt gcctggaggg 1141 aggctgccgt ggccggagcg gtgccggctc gggggctcgg gacttgctct gagcgcacgc 1201 acgcttgcca tagtaagaat tggttccccc ttcgggaggc aggttcgttc tgagcaacct 1261 ctggtctgca ctccaggacg gatctctgac attagctgga gcagacgtgt cccaagcaca 1321 aactcgctaa ctagagcctg gcttcttcgg ggaggtggca gaaagcggca atcccccctc 1381 ccccggcagc ctggagcacg gaggagggat gagggaggag ggtgcagcgg gcgggtgtgt 1441 aaggcagttt cattgataaa aagcgagttc attctggaga ctccggagcg gcgcctgcgt 1501 cagcgcagac gtcagggata tttataacaa accccctttc aagcaagtga tgctgaaggg 1561 ataacgggaa cgcagcggca ggatggaaga gacaggcact gcgctgcgga atgcctggga 1621 ggaaaagggg gagacctttc atccaggatg agggacattt aagatgaaat gtccgtggca 1681 ggatcgtttc tcttcactgc tgcatgcggc actgggaact cgccccacct gtgtccggaa 1741 cctgctcgct cacgtcggct ttccccttct gttttgttct aggacttctg cacggacctg 1801 gccgtctcca gtgccaactt cattcccacg gtcactgcca tctcgaccag tccggacctg 1861 cagtggctgg tgcagcccgc cctcgtctcc tctgtggccc catcgcagac cagagcccct 1921 caccctttcg gagtccccgc cccctccgct ggggcttact ccagggctgg cgttgtgaag 1981 accatgacag gaggccgagc gcagagcatt ggcaggaggg gcaaggtgga acaggtgagg 2041 aactctagcg tactcttcct gggaatgcgg gggctgggtg ggaagcagcc ccggagatgc 2101 aggagcccag tacagaggat gaagccactg atggggctgg ctgcacatcc gtaactggga 2161 gccctggctc caagcccatt ccatcccaac tcagactctg agtctcaccc taagaagtac 2221 tctcatagtt tcttccctaa gtttcttacc gcatgcttcc agactgggct cttctttgtt 2281 ctcttgctga ggatcttatt ttaaatgcaa gtcacaccta ttctgcaact gcaggtcaga WO 00/09525 PCT/US99/17712 EPI-109 827 2341 aatggtttca cagtggggtg ccaggaagca gggaagctgc aggagccagt tctactgggg 2401 tgggtgaatg gaggtgatgg cagacacttt tactgaatgt cggtcttttt ttgtgattat 2461 tctagttatc tccagaagaa gaagagaaaa ggagaatccg aagggaaagg aataagatgg 2521 ctgcagccaa atgccgcaac cggaggaggg agctgactga tacactccaa gcggtaggta 2581 ctctgtgggt tgctcctttt taaaacttaa gggaaagttg gagattgagc ataagggccc 2641 ttgagtaaga ctgtgtctta tgctttcctt tatccctctg tatacaggag acagaccaac 2701 tagaagatga gaagtctgct ttgcagaccg agattgccaa cctgctgaag gagaaggaaa 2761 aactagagtt catcctggca gctcaccgac ctgcctgcaa gatccctgat gacctgggct 2821 tcccagaaga gatgtctgtg gcttcccttg atctgactgg gggcctacca gaggttgcca 2881 ccccggagtc tgaggaggcc ttcaccctgc ctctcctcaa tgaccctgag cccaagccct 2941 cagtggaacc rgtcaagagc atcagcagca tggagctgaa gaccgagccc tttgatgact 3001 tcctgttccc agcatcatcc aggcccagtg gctctgagac agcccgctcc gtgccagaca 3061 tggacctatc tgggtccttc tatgcagcag actgggagcc tctgcacagt ggctccctgg 3121 ggatggggcc catggccaca gagctggagc ccctgtgcac tccggtggtc acctgtactc 3181 ccagctgcac tgcttacacg tcttccttcg tcttcaccta ccccgaggct gactccttcc 3241 ccagctgtgc agctgcccac cgcaagggca gcagcagcaa tgagccttcc tctgactcgc 3301 tcagctcacc cacgctgctg gccctgtgag ggggcaggga aggggaggca gccggcaccc 3361 acaagtgcca ctgcccgagc tggtgcatta cagagaggag aaacacatct tccctagagg 3421 gttcctgtag acctagggag gaccttatct gtgcgtgaaa cacaccaggc tgtgggcctc 3481 aaggacttga aagcatccat gtgtggactc aagtccttac ctcttccgga gatgtagcaa 3541 aacgcatgga gtgtgtattg ttcccagtga cacttcagag agctggtagt tagtagcatg 3601 ttgagccagg cctgggtctg tgtctctttt ctctttctcc ttagtcttct catagcatta 3661 actaatctat tgggttcatt attggaatta acctggtgct ggatattttc aaattgtatc 3721 tagtgcagct gattttaaca ataactactg tgttcctggc aatagtgtgt tctgattaga 3781 aatgaccaat attatactaa gaaaagatac gactttattt tctggtagat agaaataaat 3841 agctatatcc atgtactgta gtttttcttc aacatcaatg ttcattgtaa tgttactgat 3901 catgcattgt tgaggtggtc tgaatgttct gacattaaca gttttccatg aaaacgtttt 3961 attgtgtttt taatttattt attaagatgg attctcagat atttatattt ttattttatt 4021 tttttctacc ttgaggtctt ttgacatgtg gaaagtgaat ttgaatgaaa aatttaagca 4081 ttgtttgctt attgttccaa gacattgtca ataaaagcat ttaagttgaa tgcgaccaac 4141 cttgtgctct tttcattctg gaagtcttgt aagtttctga aaggtattat tggagaccag 4201 tttgtcaaga agggtagctg ctggaggggg acacaccctc tgtctgatcc cttatcaaag 4261 aggacaagga aactatagag ctgattttag aatattttac aaatacatgc cttccattgg 4321 aatgctaaga ttttctactg cttctgggga cgggaaaccg ctgtgtaaca gcttttgtgg 4381 gaatacattt tttctgtttc agtactcgca gggggaaata tttaaatttt gttgtgctaa 4441 tattaaattc agatgttttg atcttaaagg aaccctttaa gcaaacagaa cctagctttg 4501 tacagactat tttaactttt tattctcaca aaatcacgtg gagggttatt ctacttcaaa 4561 gatgagcaaa ttgaagaatg gttagaataa acaactttct tgatattccg ttatcggcat 4621 tagaatcttc ctgctcgtta tcgtatccag caggctgaac tgcctcttga tacttggtta 4681 aaaaaaattt tcaggccggg cgcggtggcc catgcctgta atcctagcac tttgggaggc 4741 cgaggcaggc ggatcacctg aggtcgggag ttcgagacca gcctgaccaa catggagaaa 4801 ccccgtcttt actaaaaata caaaattagc ctggtgtggt ggtgcatgcc tgtaatccta 4861 gctacttgag aggctgagac aggaaaatca cttgaactcg ggaggcggat gttgcagcga 4921 actgagattg cgccattgca ctccagcctg ggcaacaaga ttgaaactct gtttaaaaaa 4981 aaaagttttc actaatgtgt acattttttt gtactctttt attctcgaaa gggaaggagg 5041 gctattgccc tatcccttat taataaatgc attgtggttt ctggtttctc taataccata 5101 tgcccttcat tcagtttata gtgggcggaa gtgggggaga aaaagrtgct cagaaatcaa 5161 aagatatctc aaacagcaca aataatggct gatcgttctg caaacaaaaa gttacataat 5221 agctcaagaa ggagaagtca acatgactct gaacaagctt taacttagaa actttatcat 5281 cttaaggaag aacgtgacct ttgtccagga cgtctctggt aatggggcac ttacacacac 5341 atgcacacgt acaaaccaca gggaaaggag accgcccttc tgcctctgct cgcgagtatc 5401 acgcaggcac catgcactat gttttcacac acactgggtg gaagaagagc ttcagcgcca 5461 gtcttctaat gctttggtga taatgaaaat cactgggtgc ttatggggtg tcatattcaa 5521 tcgagttaaa agttttaatt caaaatgaca gttttactga ggttgatgtt ctcgtctatg 5581 atatctctgc ccctcccata aaaatggaca tttaaaagca acttaccgct ctttagatca 5641 ctcctatatc acacaccact tggggtgctg tttctgctag acttgaatg acagtggcct 5701 taggatccct gttggctgtt caaagggcaa atattttata gcctttaaat atacctaaac 5761 taaatacaga attaatataa ctaacaaaca cctggtctga aataacaagg tgatctaccc 5821 tggaaggaac ccagctggtg ggccaggagc ggtggctcac acctgaatt ccagcacttt 5881 gggaggctga gacaggagga tcactggagt ccaggagttt gagaccagcc tgggcaacat 5941 ggcaaaaccc agtgtgcttc tgttgtccca gctacactac tcaggaggct gaggcaggag 6001 tatgacttga gcctgggagg gggaggttgc agagaactga tattgcacca ccactgcact 6061 ccagcctggg tgacacagca aaaccctatc tcaaaaaaaa aaaaaaaaaa aaggaaccca 6121 gctggttcct gtaggtgggc aataataaca accagaggaa gaaaaggaag acgatttccc 6181 agatgaagaa gggcagctgg accttcggac (2) INFORMATION FOR SEQ ID NO:2659: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: base pairs WO 00/09525 PCT/US99/17712 EPI-109 828 (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2659 1 gcagccgggc ggccgcagaa gcgcccaggc ccgcgcgcca cccctctggc gccaccgtgg 61 ttgagcccgt gacgtttaca ctcattcata aaacgcttgt tataaaagca gtggctgcgg 121 cgcctcgtac tccaaccgca tctgcagcga gcaactgaga agccaagact gagccggcgg 181 ccgcggcgca gcgaacgagc agtgaccgtg ctcctaccca gctctgcttc acagcgccca 241 cctgtctccg cccctcggcc cctcgcccgg ctttgcctaa ccgccacgat gatgttctcg 301 ggcttcaacg cagactacga ggcgtcatcc tcccgccgca gcagcgcgtc cccggccggg 361 gatagcctct cttactacca ctcacccgca gactccttct ccagcatggg ctcgcctgtc 421 aacgcgcagg taaggctggc ttcccgtcgc cgcggggccg ggggcttggg gtcgcggagg 481 aggagacacc gggcgggacg ctccagtaga tgagtagggg gctcccttgt gcctggaggg 541 aggctgccgt ggccggagcg gtgccggctc gggggctcgg gacttgctct gagcgcacgc 601 acgcttgcca tagtaagaat tggttccccc ttcgggaggc aggttcgttc tgagcaacct 661 ctggtctgca ctccaggacg gatctctgac attagctgga gcagacgtgt cccaagcaca 721 aactcgctaa ctagagcctcg gcttcttcgg ggaggtggca gaaagcggca atcccccctc 781 ccccggcagc ctggagcacg gaggagggat gagggaggag ggtgcagcgg gcgggtgtgt 841 aaggcagttt cattgataaa aagcgagttc attctggaga ctccggagcg gcgcctgcgt 901 cagcgcagac gtcagggata tttataacaa accccctttc aagcaagtga tgctgaaggg 961 ataacgggaa cgcagcggca ggatggaaga gacaggcact gcgctgcgga atgcctggga 1021 ggaaaagggg gagacctttc atccaggatg agggacattt aagatgaaat gtccgtggca 1081 ggatcgtttc tcttcactgc tgcatgcggc actgggaact cgccccacct gtgtccggaa 1141 cctgctcgct cacgtcggct ttccccttct gttttgttct aggacttctg cacggacctg 1201 gccgtctcca gtgccaactt cattcccacg gtcactgcca tctcgaccag tccggacctg 1261 cagtggctgg gcagcccgc cctcgtctcc tctgtggccc catccagac cagagcccct 1321 caccctttcg gagtccccgc cccctccgct ggggcttact ccagggctgg cgttgtgaag 1381 accatgacag gaggccgagc gcagagcatt ggcaggaggg gcaaggtgga acaggtgagg 1441 aactctagcg tactcttcct gggaatgtgg gggctgggtg ggaagcagcc ccggagatgc 1501 aggagcccag tacagagga t gaagccactg atggggctgg ctgcacatcc gtaactggga 1561 gccctggctc caagcccatt ccatcccaac tcagactctg agtctcaccc taagaagtac 1621 tctcatagtt tcttccctaa gtttcttacc gcatgctttc agactgggct cttctttgtt 1681 ctcttgctga ggatcttatt ttaaatgcaa gtcacaccta ttctgcaact gcaggtcaga 1741 aatggtttca cagtggggtg ccaggaagca gggaagctgc aggagccagt tctactgggg 1801 tgggtgaatg gaggtgatgg cagacacttt tactgaatgt cggtcttttt ttgtgattat 1861 tctagttatc tccagaagaa gaagagaaaa ggagaatccg aagggaaagg aataagatgg 1921 ctgcagccaa atgccgcaac cggaggaggg agctgactga tacactccaa gcggtaggta 1981 ctctgtgggt tgctcctttt taaaacttaa gggaaagttg gagattgagc ataagggccc 2041 ttgagtaaga ctgtgtctta tgctttcctt tatccctctg tatacaggag acagaccaac 2101 tagaagatga gaagtctgct ttgcagaccg agattgccaa cctgctgaag gagaaggaaa 2161 aactagagtt catcctggca gctcaccgac ctgcctgcaa gatccctgat gacctgggct 2221 tcccagaaga gatgtctgtg gcttcccttg atctgactgg gggcctgcca gaggttgcca 2281 ccccggagtc tgaggaggcc ttcaccctgc ctctcctcaa tgaccctgag cccaagccct 2341 cagtggaacc tgtcaagagc atcagcagca tggagctgaa gaccgagccc tttgatgact 2401 tcctgttccc agcatcatcc aggcccagtg gctctgagac agcccgctcc gtgccagaca 2461 tggacctatc tgggtccttc tatgcagcag actgggagcc tctgcacagt ggctccctgg 2521 ggatggggcc catggccaca gagctggagc ccctgtgcac tccggtggtc acctgtactc 2581 ccagctgcac tgcttacacg tcttccttcg tcttcaccta ccccgaggct gactccttcc 2641 ccagctgtgc agctgcccac cgcaagggca gcagcagcaa tgagccttcc tctgactcgc 2701 tcagctcacc cacgctgctg gccctgtgag ggggcaggga aggggaggca gccggcaccc 2761 acaagtgcca ctgcccgagc tggtgcatta cagagaggag aaacacatct tccctagagg 2821 gttcctgtag acctagggag gaccttatct gtgcgtgaaa cacaccaggc tgtgggcctc 2881 aaggacttga aagcatccat gtgtggactc aagtccttac ctcttccgga gatgtagcaa 2941 aacgcatgga gtgtgtattg ttcccagtga cacttcagag agctggtagt tagtagcatg 3001 ttgagccagg cctgggtctg tgtctctttt ctctttctcc ttagtcttct catagcatta 3061 actaatctat tgggttcatt attggaatta acctggtgct ggatattttc aaattgtatc 3121 tagtgcagct gattttaaca ataactactg tgttcctggc aatagtgtgt tctgattaga 3181 aatgaccaat attatactaa gaaaagatac gactttattt tctggtagat agaaataaat 3241 agctatatcc atgtactgta gtttttcttc aacatcaatg ttcattgtaa tgttactgat 3301 catgcattgt tgaggtggac tgaatgttct gacattaaca gttttccatg aaaacgtttt 3361 attgtgtttt taatttattt attaagatgg attctcagat atttatattt ttattttatt 3421 tttttctacc ttgaggtctt ttgacatgtg gaaagtgaat ttgaatgaaa aatttaagca 3481 ttgtttgctt attgttccaa gacattgtca ataaaagcat ttaagtgaa tgcgaccaac 3541 cttgtgctct tttcattctg gaagt (2) INFORMATION FOR SEQ ID NO:2660: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: base pairs (B) TYPE: nucleic acid WO 00/09525 PCT/US99/17712 EPI-109 829 (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2660 1 cctcgaggtc gaagcttatt taaaagcata ttttccaatg cctgctttag ctgtggaaaa 61 ggaagactct ccgagggcaa atccaggagt catggaaaac aatgggcagg gcagcttggt 121 gctgtgactg gatgggtctt taaggttgtt tcccttgaat aaagaatgag ggaattccac 181 caggggaagg agagtagacc aaacatttgg tgaacagaaa gggagacaga gtctttagtg 241 ttattcccca aatattcctg gagagncctt tgagacacct ggtaggatta tagtgatcta 301 aagaggcatg gccatgtgac tgcttnggcc aatgatgtat gggcagaagt gatgtgtgcc 361 ataagtggat gctctgacag acatgatgtt ccgagttcct tccccacagn caggatagct 421 gtgaaaaggg gtatcaacac gaggcctcct tcagcctgag ccctttagtg actacaatga 481 gcagagctac cctgccaacc tacaacggtc atgtagnaga aatgaccaac tttcactgga 541 ataagncact gatatgttag ggttgnntgg tagggcagca taacactnnc tntcctgaca 601 gaactgggag tgagagataa ggctggagag agaaggagtt ggattgtgaa aanccccttc 661 tccaaggcat aggaatcgga actctcctga ttgtaaggaa aagccaatga aggcttccaa 721 gcaggggcgt taacatgaac agatttgtta tttttttgga tgaaatatgc tatttctcaa 781 cataaggaga agatcagcct actaaaccac atgaggcaga gaggaacaca cagaacctta 841 gccaaaagat atatatttat gcaaagtcct aagtcttgaa atttctaaat acaggagctc 901 tgaacggagt tacagtcaga ggatcaggca agaaaatttc ttctatgcca caagcgctat 961 ttcctctgca gataactaat actccacaag aaagtttgcc agagtagaga aaatacaaag 1021 gaatgtaaca cagacctgag gtcaatttcc agctgcctgt gtgacctcaa caaagatact 1081 taacctctct gggcctattt cctcacatgt taaatctgga taataatata tgtctctcaa 1141 gacagttgtg gggagaaaac agcgtattta aattgcttag gagaatgcct ggcagataat 1201 aagtgtttaa tacatgaaac tgatttttat tactgttatt aaaaaatatt tagaacacca 1261 actccctgaa tacaacagaa aatgattcag ggcaacagac agaggagaat gttctctcct 1321 tgaggaagca actggatctt gtcatcactg tatacctacc taccccaccc cctccccagc 1381 tcagtgcctg gctcacagta ggctttcagt taccctctgc agatcagtga aagctaggtg 1441 agtgcccgga gtgaagaaaa gttggcaggt ttcccactga taccagctgc tgttggtttc 1501 tgaacactca aagccgcaaa taccttaggg ctgggggcaa tgaacccaag gctgaattcc 1561 aagttcagaa gcagcgaagt ctgaatttag aacctaggac ttaaactgct gcaggtccaa 1621 cttcaagccc cagttttaga cagaggcttg ggaaagatct gacttctaac ccggttcccc 1681 ctcccctcct cccctcgatg cttctcacag gaaagtacac ctggtcctgc caaatcgcac 1741 tcttatatcc tggcatccta tccaggctct gcgaggatgg aaactgcgag gcaggggagg 1801 gaagcgggct gtttggccac cacctcccta gtgctgcagg cgaccctgtc acactaaact 1861 cctggcagcc cagtgaggtg gacggcaccg ccccacctgc agatgaggga aatgaagctc 1921 ggaggagttc cgtgatttgc ttgcttcaca ctgtggtagc ctggccacga aagaaccaag 1981 gattccgact tcggattctt ccaccacaca ctttcgtcct aagggtgggg gcggggggag 2041 aataaaataa ccgcggaaaa ggaaccactt acatgtgtct agcgcttcct agaggctacc 2101 caggatatgc gcccaccacc cggccggagt gcagagattt gaagtccagg ttctaccccg 2161 ggctccgagt actactgcgt gactttatgc gagtgtcgcc gccttctggg cttgttttcc 2221 cggaagcaac tcggcgcgga tggagtgtgt gtgtgcgcgc gcgcgttatg ttgtgcgtgt 2281 tgtgttagcg tgtgcgtgtt gtccgagttt cggatcgcct acacctgtga acccccgcgc 2341 cctttccccc acggtcccgg agatgaagtg gggtgcaacg gagactcagc tgagcgtcca 2401 gtttcgggca atacaaatct ctcggcttct acgagcagcc acacgacccc gcggaccgtc 2461 gctcctgaac ttgaccgaga tgcaaacttc ggagtgttct caacgtgggg gccgactctc 2521 ggagaccgcc ctaaacttaa gtccccttag gctcgcccca cctggacttc acatagccac 2581 cttaagggcg gtattcccgc ccccggaagt gcgggtggca gcgtacttgg attctcagcc 2641 tccagccccg cgcggtggcg gccgcggtgg atgacttcgg gccccacaag tggaaacaac 2701 aaccacccct cgcccgcacc cctggcccaa aacaactggc caggttccct cgtcccgggt 2761 ccctgcatcc cccgcarccc cgtccgcagc cgtgaacttg agcccccctc catcagaggt 2821 tgcgagcgtc gccgctcggc agccaccgtc actagacagt caaaccccaa gacgtcagcc 2881 cacaatgcac cgggcgggcc gggaaaaacg gcccggggag gggaccgggg aacagagggc 2941 cgagaggcgt gcggcagggg ggagggtagg agaaagaagg gcccgactgt aggagggcag 3001 cggagcatta cctcatcccg tgagcctccg .cgggcccaga gaagaatctt ctagggtgga 3061 gtctccatgg tgacgggcgg gcccgccccc ctgagagcga cgcgagccaa tgggaaggcc 3121 ttggggtgac atcatgggct atttttaggg gttgactggt agcagataag tgttgagctc 3181 gggctggata agggctca (2) INFORMATION FOR SEQ ID NO:2661: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2661 1 cccggggagg ggaccgggga acagagggcc gagaggcgtg cggcaggggg gagggtagga 61 gaaagaaggg cccgactgta ggagggcagc ggagcattac ctcatcccgt gagcctccgc 121 gggcccagag aagaatcttc tagggtggag tctccatggt gacgggcggg cccgcccccc 181 tgagagcgac gcgagccaat gggaaggcct tggggtgaca tcatgggcta tttttagggg WO 00/09525 PCT/US99/17712 EPI-109 830 241 ttgactggta gcagataagt gttgagctcg ggctggataa gggctcagag ttgcactgag 301 tgtggctgaa gcagcgaggc gggagtggag gtgcgcggag tcaggcagac agacagacac 361 agccagccag ccaggtcggc agtatagtcc gaactgcaaa tcttattttc ttttcacctt 421 ctctctaact gcccagagct agcgcctgtg gctcccgggc tggtggttcg ggagtgtcca 481 gagagccttg tctccagccg gccccgggag gagagccctg ctgcccaggc gctgttgaca 541 gcggcggaaa gcagcggtac cccacgcgcc cgccggggga cgtcggcgag cggctgcagc 601 agcaaagaac tttcccggcg gggaggaccg gagacaagtg gcagagtccc ggagcgaact 661 tttgcaagcc tttcctgcgt cttaggcttc tccacggcgg taaagaccag aaggcggcgg 721 agagccacgc aagagaagaa ggacgtgcgc tcagcttcgc tcgcaccggt tgttgaactt 781 gggcgagcgc gagccgcggc tgccgggcgc cccctccccc tagcagcgga ggaggggaca 841 agtcgtcgga gtccgggcgg ccaagacccg ccgccggccg gccactgcag ggtccgcact 901 gatccgctcc gcggggagag ccgctgctct gggaagtgag ttcgcctgcg gactccgagg 961 aaccgctgcg cccgaagagc gctcagtgag tgaccgcgac ttttcaaagc cgggtagcgc 1021 gcgcgagtcg acaagtaaga gtgcgggagg catcttaatt aaccctgcgc tccctggagc 1081 gagctggtga ggagggcgca gcggggacga cagccagcgg gtgcgtgcgc tcttagagaa 1141 actttccctg tcaaaggctc cggggggcgc gggtgtcccc cgcttgccag agccctgttg 1201 cggccccgaa acttgtgcgc gcacgccaaa ctaacctcac gtgaagtgac ggactgttct 1261 atgactgcaa agatggaaac gaccttctat gacgatgccc tcaacgcctc gttcctcccg 1321 tccgagagcg gaccttatgg ctacagtaac cccaagatcc tgaaacagag catgaccctg 1381 aacctggccg acccagtggg gagcctgaag ccgcacctcc gcgccaagaa ctcggacctc 1441 ctcacctcgc ccgacgtggg gctgctcaag ctggcgtcgc ccgagctgga gcgcctgata 1501 atccagtcca gcaacgggca catcaccacc acgccgaccc ccacccagtt cctgtgcccc 1561 aagaacgtga cagatgagca ggaggggttc gccgagggct tcgtgcgcgc cctggccgaa 1621 ctgcacagcc agaacacgct gcccagcgtc acgtcggcgg cgcagccggt caacggggca 1681 ggcatggtgg ctcccgcggt agcctcggtg gcagggggca gcggcagcgg cggcttcagc 1741 gccagcctgc acagcgagcc gccggtctac gcaaacctca gcaacttcaa cccaggcgcg 1801 ctgagcagcg gcggcggggc gccctcctac ggcgcggccg gcctggcctt tcccgcgcaa 1861 ccccagcagc agcagcagcc gccgcaccac ctgccccagc agatgcccgt gcagcacccg 1921 cggctgcagg ccctgaagga ggagcctcag acagtgcccg agatgcccgg cgagacaccg 1981 cccctgtccc ccatcgacat ggagtcccag gagcggatca aggcggagag gaagcgcatg 2041 aggaaccgca tcgctgcctc caagtgccga aaaaggaagc tggagagaat cgcccggctg 2101 gaggaaaaag tgaaaacctt gaaagctcag aactcggagc tggcgtccac ggccaacatg 2161 ctcagggaac aggtggcaca gcttaaacag aaagtcatga accacgttaa cagtgggtgc 2221 caactcatgc taacgcagca gttgcaaaca ttttgaagag agaccgtcgg gggctgaggg 2281 gcaacgaaga aaaaaaataa cacagagaga cagacttgag aacttgacaa gttgcgacgg 2341 agagaaaaaa gaagtgtccg agaactaaag ccaagggtat ccaagttgga ctgggttcgg 2401 tctgacggcg cccccagtgt gcacgagtgg gaaggacttg gtcgcgccct cccttggcgt 2461 ggagccaggg agcggccgcc tgcgggctgc cccgctttgc ggacgggctg tccccgcgcg 2521 aacggaacgt tggactttcg ttaacattga ccaagaactg catggaccta acattcgatc 2581 tcattcagta ttaaaggggg gagggggagg gggttacaaa ctgcaataga gactgtagat 2641 tgcttctgta gtactcctta agaacacaaa gcggggggag ggttggggag gggcggcagg 2701 agggaggttt gtgagagcga ggctgagcct acagatgaac tctttctggc ctgctttcgt 2761 taactgtgta tgtacatata tatatttttt aatttgatta aagctgatta ctgtcaataa 2821 acagcttcat gcctttgtaa gttatttctt gtttgtttgt ttgggtatcc tgcccagtgt 2881 tgtttgtaaa taagagattt ggagcactct gagtttacca tttgtaataa agtatataat 2941 ttttttatgt tttgtttctg aaaattccag aaaggatatt taagaaaata caataaacta 3001 ttggaaagta ctcccctaac ctcttttctg catcatctgt agatcctagt ctatctaggt 3061 ggagttgaaa gagttaagaa tgctcgataa aatcactctc agtgcttctt actattaagc 3121 agtaaaaact gttctctatt agacttagaa ataaatgtac ctgatgtacc tgatgctatg 3181 tcaggcttca tactccacgc tcccccagcg tatctatatg gaattgctta ccaaaggcta 3241 gtgcgatgtt tcaggaggct ggaggaaggg gggttgcagt ggagagggac agcccactga 3301 gaagtcaaac atttcaaagt ttggattgca tcaagtggca tgtgctgtga ccatttataa 3361 tgttagaaat tttacaatag gtgcttattc tcaaagcagg aattggtggc agattttaca 3421 aaagatgtat ccttccaatt tggaatcttc tctttgacaa ttcctagata aaaagatggc 3481 ctttgtctta tgaatattta taacagcatt ctgtcacaat aaatgtattc aaataccaat 3541 aacagatctt gaattgcttc cctttactac ttttttgttc ccaagttata tactgaagtt 3601 tttattttta gttgctgagg tt (2) INFORMATION FOR SEQ ID NO:2662: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: _base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2662 1 gcaggaacag tgctagtatt gctcgagccc gagggctgga ggttagggga tgaaggtctg 61 cttccacgct ttgcactgaa ttagggctag aattggggat 9ggggtaggg gcgcattcct 121 tcgggagccg aggcttaagt cctcggggtc ctgtactcga tgccgtttct cctatctctg 181 agcctcagaa ctgtcttcag tttccgtaca agggtaaaaa ggcgctctct gccccatccc WO 00/09525 PCTIUS99/17712 EPI-109 831 241 ccccgacctc gggaacaagg gtccgcattg aaccaggtgc gaatgttctc tctcattctg 301 cgccgttccc gcctcccctc ccccagccgc ggcccccgcc tccccccgca ctgcaccctc 361 ggtgttggct gcagcccgcg agcagttccc gtcaatccct ccccccttac acaggatgtc 421 catattagga catctgcgtc agcaggtttc cacggccttt ccctgtagcc ctggggggag 481 ccatccccga aacccctcat cttggggggc ccacgagacc tctgagacag gaactgcgaa 541 atgctcacga gattaggaca cgcgccaagg cgggggcagg gagctgcgag cgctggggac 601 gcagccgggc ggccgcagaa gcgcccaggc ccgcgcgcca cccctctggc gccaccgtgg 661 ttgagcccgt gacgtttaca ctcattcata aaacgcttgt tataaaagca gtggctgcgg 721 cgcctcgtac tccaaccgca tctgcagcga gcaactgaga agccaaaact gagccggcgg 781 ccgcggcgca gcgaacgagc agtgaccgtg ctcctaccca gctctgcttc acagcgccca 841 cctgtctccg cccctcggcc cctcgcccgg ctttgcctaa ccgccacgat gatgttctcg 901 ggcttcaacg cagactacga ggcgtcatcc tcccgctgca gcagcgcgtc cccggccggg 961 gatagcctct cttactacca ctcacccgca gactccttct ccagcatggg ctcgcctgtc 1021 aacgcgcagg taaggctggc ttcccgtcgc cgcggggccg ggggcttggg gtcgcggagg 1081 aggagacacc gggcgggacg ctccagtaga tgagtagggg gctcccttgt gcctggaggg 1141 aggctgccgt ggccggagcg gtgccggctc gggggctcgg gacttgctct gagcgcacgc 1201 acgcttgcca tagtaagaat tggttccccc ttcgggaggc aggttcgttc tgagcaacct 1261 ctggtctgca ctccaggacg gatctctgac attagctgga gcagacgtgt cccaagcaca 1321 aactcgctaa ctagagcctg gcttcttcgg ggaggtggca gaaagcggca atcccccctc 1381 ccccggcagc ctggagcacg gaggagggat gagggaggag ggtgcagcgg gcgggtgtgt 1441 aaggcagttt cattgataaa aagcgagttc attctggaga ctccggagcg gcgcctgcgt 1501 cagcgcagac gtcagggata tttataacaa accccctttc aagcaagtga tgctgaaggg 1561 ataacgggaa cgcagcggca ggatggaaga gacaggcact gcgctgcgga atgcctggga 1621 ggaaaagggg gagacctttc atccaggatg agggacattt aagatgaaat gtccgtggca 1681 ggatcgtttc tcttcactgc tgcatgcggc actgggaact cgccccacct gtgtccggaa 1741 cctgctcgct cacgtcggct ttccccttct gttttgttct aggacttctg cacggacctg 1801 gccgtctcca gtgccaactt cattcccacg gtcactgcca tctcgaccag tccggacctg 1861 cagtggctgg tgcagcccgc cctcgtctcc tctgtggccc catcgcagac cagagcccct 1921 caccctttcg gagtccccgc cccctccgct ggggcttact ccagggctgg cgttgtgaag 1981 accatgacag gaggccgagc gcagagcatt ggcaggaggg gcaaggtgga acaggtgagg 2041 aactctagcg tactcttcct gggaatgtgg gggctgggtg ggaagcagcc ccggagatgc 2101 aggagcccag tacagaggat gaagccactg atggggctgg ctgcacatcc gtaactggga 2161 gccctggcgc caagcccatt ccatcccaac tcagactctg agtctcaccc taagaagtac 2221 tctcatagtt tcttccctaa gtttcttacc gcatgctttc agactgggct cttctttgtt 2281 ctcttgctga ggatcttatt ttaaatgcaa gtcacaccta ttctgcaact gcaggtcaga 2341 aatggtttca cagtggggtg ccaggaagca gggaagctgc aggagccagt tctactgggg 2401 tgggtgaatg gaggtgatgg cagacacttt tactgaatgt cggtcttttt ttgtgattat 2461 tctagttatc tccagaagaa gaagagaaaa ggagaatccg aagggaaagg aataagatgg 2521 ctgcagccaa atgccgcaac cggaggaggg agctgactga tacactccaa gcggtaggta 2581 ctctgtgggt tgctcctttt taaaacttaa gggaaagttg gagattgagc ataagggccc 2641 ttgagtaaga ctgtgtctta tgctttcctt tatccctctg tatacaggag acagaccaac 2701 tagaagatga gaagtctgct ttgcagaccg agattgccaa cctgctgaag gagaaggaaa 2761 aactagagtt catcctggca gctcaccgac ctgcctgcaa gatccctgat gacctgggct 2821 tcccagaaga gatgtctgtg gcttcccttg atctgactgg gggcctgcca gaggttgcca 2881 ccccggagtc tgaggaggcc ttcaccctgc ctctcctcaa tgaccctgag cccaagccct 2941 cagtggaacc tgtcaagagc atcagcagca tggagctgaa gaccgagccc tttgatgact 3001 tcctgttccc agcatcatcc aggcccagtg gctctgagac agcccgctcc gtgccagaca 3061 tggacctatc tgggtccttc tatgcagcag actgggagcc tctgcacagt ggctccctgg 3121 ggatggggcc catggccaca gagctggagc ccctgtgcac tccggtggtc acctgtactc 3181 ccagctgcac tgcttacacg tcttccttcg tcttcaccta ccccgaggct gactccttcc 3241 ccagctgtgc agctgcccac cgcaagggca gcagcagcaa tgagccttcc tctgactcgc 3301 tcagctcacc cacgctgctg gccctgtgag ggggcaggga aggggaggca gccggcaccc 3361 acaagtgcca ctgcccgagc tggtgcatta cagagaggag aaacacatct tccctagagg 3421 gttcctgtag acctagggag gaccttatct gtgcgtgaaa cacaccaggc tgtgggcctc 3481 aaggacttga aagcatccat gtgtggactc aagtccttac ctcttccgga gatgtagcaa 3541 aacgcatgga gtgtgtattg ttcccagtga cacttcagag agctggtagt tagtagcatg 3601 ttgagccagg cctgggtctg tgtctctttt ctctttctcc ttagtcttct catagcatta 3661 actaatctat tgggttcatt attggaatta acctggtgct ggatattttc aaattgtatc 3721 tagtgcagct gattttaaca ataactactg tgttcctggc aatagtgtg tctgattaga 3781 aatgaccaat attatactaa gaaaagatac gactttattt tctggtagat agaaataaat 3841 agctatatcc atgtactgta gtttttcttc aacatcaatg ttcattgtaa tgttactgat 3901 catgcattgt tgaggtggtc tgaatgttct gacattaaca gttttccatg aaaacgtttt 3961 attgtgtttt taatttattt attaagatgg attctcagat atttatattt ttattttatt 4021 tttttctacc ttgaggtctt ttgacatgtg gaaagtgaat ttgaatgaaa aatttaagca 4081 ttgtttgctt attgttccaa gacattgtca ataaaagcat ttaagttgaa tgcgaccaac 4141 cttgtgctct tttcattctg gaagtcttgt aagtttctga aaggtattat tggagaccag 4201 tttgtcaaga agggtagctg ctggaggggg acacaccctc tgtctgatcc cttatcaaag 4261 aggacaagga aactatagag ctgattttag aatattttac aaatacatgc cttccattgg WO 00/09525 PCT/US99/17712 EPI-109 832 4321 aatgctaaga ttttctactg cttctgggga cgggaaaccg ctgtgtaaca gcttttgtgg 4381 gaatacattt tttctgtttc agtactcgca gggggaaata tttaaatttt gttgtgctaa 4441 tattaaattc agatgttttg atcttaaagg aaccctttaa gcaaacagaa cctagctttg 4501 tacagactat tttaactttt tattctcaca aaatcacgtg gagggttatt ctacttcaaa 4561 gatgagcaaa ttgaagaatg gttagaataa acaactttct tgatattccg ttatcggcat 4621 tagaatcttc ctgctcgtta tcgtatccag caggctgaac tgcctcttga tacttggtta 4681 aaaaaaattt tcaggccggg cgcggtggcc catgcctgta atcctagcac tttgggaggc 4741 cgaggcaggc ggatcacctg aggtcgggag ttcgagacca gcctgaccaa catggagaaa 4801 ccccgtcttt actaaaaata caaaattagc ctggtgtggt ggtgcatgcc tgtaatccta 4861 gctacttgag aggctgagac aggaaaatca cttgaactcg ggaggcggat gttgcagcga 4921 actgagattg cgccattgca ctccagcctg ggcaacaaga ttgaaactct gtttaaaaaa 4981 aaaagttttc actaatgtgt acattttttt gtactctttt attctcgaaa gggaaggagg 5041 gctattgccc tatcccttat taataaatgc attgtggttt ctggtttctc taataccata 5101 tgcccttcat tcagtttata gtgggcggaa gtgggggaga aaaagttgct cagaaatcaa 5161 aagatatctc aaacagcaca aataatggct gatcgttctg caaacaaaaa gttacataat 5221 agctcaagaa ggagaagtca acatgactct gaacaagctt taacttagaa actttatcat 5281 cttaaggaag aacgtgacct ttgtccagga cgtctctggt aatggggcac ttacacacac 5341 atgcacacgt acaaaccaca gggaaaggag accgcccttc tgcctctgct cgcgagtatc 5401 acgcaggcac catgcactat gttttcacac acactgggtg gaagaagagc ttcagcgcca 5461 gtcttctaat gctttggtga taatgaaaat cactgggtgc ttatggggtg tcatattcaa 5521 tcgagttaaa agttttaatt caaaatgaca gttttactga ggttgatgtt ctcgtctatg 5581 atatctctgc ccctcccata aaaatggaca tttaaaagca acttaccgct ctttagatca 5641 ctcctatatc acacaccact tggggtgctg tttctgctag acttgtgatg acagtggcct 5701 taggatccct gtttgctgtt caaagggcaa atattttata gcctttaaat atacctaaac 5761 taaatacaga attaatataa ctaacaaaca cctggtctga aataacaagg tgatctaccc 5821 tggaaggaac ccagctggtg gqccaggagc ggtggctcac acctgtaatt ccagcacttt 5881 gggaggctga gacaggagga tcactggagt ccaggagttt gagaccagcc tgggcaacat 5941 ggcaaaaccc agtgtgcttc tgttgtccca gctacactac tcaggaggct gaggcaggag 6001 tatgacttga gcctgggagg gggaggttgc agagaactga tattgcacca ccactgcact 6061 ccagcctggg tgacacagca aaaccctatc tcaaaaaaaa aaaaaaaaaa aaggaaccca 6121 gctggttcct gtaggtgtgc aataataaca accagaggaa gaaaaggaag acgatttccc 6181 agatgaagaa gggcagctgg accttcggac 1 gcagccgggc ggccgcagaa gcgcccaggc ccgcgcgcca cccctctggc gccaccgtgg 61 ttgagcccgt gacgtttaca ctcattcata aaacgcttgt tataaaagca gtggctgcgg 121 cgcctcgtac tccaaccgca tctgcagcga gcaactgaga agccaagact gagccggcgg 181 ccgcggcgca gcgaacgagc agtgaccgtg ctcctaccca gctctgcttc acagcgccca 241 cctgtctccg cccctcggcc cctcgcccgg ctttgcctaa ccgccacgat gatgttctcg 301 ggcttcaacg cagactacga ggcgtcatcc tcccgctgca gcagcgcgtc cccggccggg 361 gatagcctct cttactacca ctcacccgca gactccttct ccagcatggg ctcgcctgtc 421 aacgcgcagg taaggctggc ttcccgtcgc cgcggggccg ggggcttggg gtcgcggagg 481 aggagacacc gggcgggacg ctccagtaga tgagtagggg gctcccttgt gcctggaggg 541 aggctgccgt ggccggagcg gtgccggctc gggggctcgg gacttgctct gagcgcacgc 601 acgcttgcca tagtaagaat tggttccccc ttcgggaggc aggttcgttc tgagcaacct 661 ctggtctgca ctccaggacg gatctctgac attagctgga gcagacgtgt cccaagcaca 721 aactcgctaa ctagagcctg gcttcttcgg ggaggtggca gaaagcggca atcccccctc 781 ccccggcagc ctggagcacg gaggagggat gagggaggag ggtgcagcgg gcgggtgtgt 841 aaggcagttt cattgataaa aagcgagttc attctggaga ctccggagcg gcgcctgcgt 901 cagcgcagac gtcagggata tttataacaa accccctttc aagcaagtga tgctgaaggg 961 ataacgggaa cgcagcggca ggatggaaga gacaggcact gcgctgcgga atgcctggga 1021 ggaaaagggg gagacctttc atccaggatg agggacattt aagatgaaat gtccgtggca 1081 ggatcgtttc tcttcaccgc tgcatgcggc actgggaact cgccccacct gtgtccggaa 1141 cctgctcgct cacgtcggct ttccccttct gttttgttct aggacttctg cacggacctg 1201 gccgtctcca gtgccaactt cattcccacg gtcactgcca tctcgaccag tccggacctg 1261 cagtggctgg tgcagcccgc cctcgtctcc tctgtggccc catcgcagac cagagcccct 1321 caccctttcg gagtccccgc cccctccgct ggggcttact ccagggctgg cgttgtgaag 1381 accatgacag gaggccgagc gcagagcatt ggcaggaggg gcaaggtgga acaggtgagg 1441 aactctagcg tactcttcct gggaatgtgg gggctgggtg ggaagcagcc ccggagatgc 1501 aggagcccag tacagaggat gaagccactg atggggctgg ctgcacatcc gtaactggga 1561 gccctggctc caagcccatt ccatcccaac tcagactctg agtctcaccc taagaagtac 1621 tctcatagt tcttccctaa gtttcttacc gcatgctttc agactgggct cttctttgtt 1681 ctcttgctga ggatcttatt ttaaatgcaa gtcacaccta ttctgcaact gcaggtcaga 1741 aatggtttca cagtggggtg ccaggaagca gggaagctgc aggagccagt tctactgggg 1801 tgggtgaatg gaggtgatgg cagacacttt tactgaatgt cggtcttttt ttgtgattat 1861 tctagttatc tccagaagaa gaagagaaaa ggagaatccg aagggaaagg aataagatgg 1921 ctgcagccaa atgccgcaac cggaggaggg agctgactga acactccaa gcggtaggta 1981 ctctgtgggt tgctcctttt taaaactaa gggaaagttg gagattgagc ataagggccc 2041 ttgagtaaga ctgtgtctta tgctttcctt tatccctctg tatacaggag acagaccaac 2101 tagaagatga gaagtctgct ttgcagaccg agattgccaa cctgctgaag gagaaggaaa WO 00/09525 PCT/US99/17712 EPI-109 833 2161 aactagagtt catcctacca gctcaccgac ctgcctgcaa gatccctgat gacctgggct 2221 tcccagaaga gatgtctatg gcttcccttg atctgactgg gggcctgcca gaggttgcca 2281 ccccggagtc tgaggaagcc ttcaccctgc ctctcctcaa tgaccctgag cccaagccct 2341 cagtggaacc tgtcaagagc atcagcagca tggagctgaa gaccgagccc tttgatgact 2401 tcctgttccc agcatcatcc aggcccagtg gctctgagac agcccgctcc gtgccagaca 2461 tggacctatc tgggtccttc tatgcagcag actgggagcc tctgcacagt ggctccctgg 2521 ggatggggcc catggccaca gagctggagc ccctgtgcac tccggtggtc acctgtactc 2581 ccagctgcac tgcttacacg tcttccttcg tcttcaccta ccccgaggct gactccttcc 2641 ccagctgtgc agctgcccac cgcaagggca gcagcagcaa tgagccttcc tctgactcgc 2701 tcagctcacc cacgctactg gccctgtgag ggggcaggga aggggaggca gccggcaccc 2761 acaagtgcca ctgcccaagc tggtgcatta cagagaggag aaacacatct tccctagagg 2821 gttcctgtag acctagagag gaccttatct gtgcgtgaaa cacaccaggc tgtgggcctc 2881 aaggacttga aagcatccat gtgtggactc aagtccttac ctcttccgga gatgtagcaa 2941 aacgcatgga gtgtgtattg ttcccagtga cacttcagag agctggtagt tagtagcatg 3001 ttgagccagg cctgggtctg tgtctctttt ctctttctcc ttagtcttct catagcatta 3061 actaatctat tgggttcatt attggaatta acctggtgct ggatattttc aaattgtatc 3121 tagtgcagct gattttaaca ataactactg tgttcctggc aatagtgtgt tctgattaga 3181 aatgaccaat attatactaa gaaaagatac gactttattt tctggtagat agaaataaat 3241 agctatatcc atgtactgta gtttttcttc aacatcaatg ttcattgtaa tgttactgat 3301 catgcattgt tgaggtggtc tgaatgttct gacattaaca gttttccatg aaaacgtttt 3361 attgtgtttt taatttatct attaagatgg attctcagat atttatattt ttattttatt 3421 tttttctacc ttgaggtctt ttgacatgtg gaaagtgaat ttgaatgaaa aatttaagca 3481 ttgtttgctt attgttccaa gacattgtca ataaaagcat ttaagttgaa tgcgaccaac 3541 cttgtgctct tttcattctg gaagt 1 cctcgaggtc gaagcttatt taaaagcata ttttccaatg cctgctttag ctgtggaaaa 61 ggaagactct ccgagggcaa atccaggagt catggaaaac aatgggcagg gcagcttggt 121 gctgtgactg gatgggtctt taaggttgtt tcccttgaat aaagaatgag ggaattccac 181 caggggaagg agagtaacc aaacatttgg tgaacagaaa gggagacaga gtctttagtg 241 ttattcccca aatattcccg gagagncctt tgagacacc ggtaggatta tagtgatcta 301 aagaggcatg gccatgtgac tgcttnggcc aatgatgtat gggcagaagt gatgtgtgcc 361 ataagtggat gctctgacag acatgatgtt ccgagttcct tccccacagn caggatagct 421 gtgaaaaggg gtatcaacac gaggcctcct tcagcctgag ccctttagtg actacaatga 481 gcagagctac cctgccaacc tacaacggtc atgtagnaga aatgaccaac tttcactgga 541 ataagncact gatatgttag ggttgnntgg tagggcagca taacactnnc tntcctgaca 601 gaactgggag tgagagataa ggctggagag agaaggagtt ggattgtgaa aanccccttc 661 tccaaggcat aggaatcgga actctcctga ttgtaaggaa aagccaatga aggcttccaa 721 gcaggggcgt taacatgaac agatttgtta tttttttgga tgaaatatgc tatttctcaa 781 cataaggaga agatcaacct actaaaccac atgaggcaga gaggaacaca cagaacctta 841 gccaaaagat atatatttat gcaaagtcct aagtcttgaa atttctaaat acaggagctc 901 tgaacggagt tacagtcaga ggatcaggca agaaaatttc ttctatgcca caagcgctat 961 ttcctctgca gataactaat actccacaag aaagtttgcc agagtagaga aaatacaaag 1021 gaatgtaaca cagacctgag gtcaatttcc agctgcctgt ggacctcaa caaagatact 1081 taacctctct gggcctattt cctcacatgt taaatctgga taataatata tgtctctcaa 1141 gacagttgtg gggagaaaac agcgtattta aattgcttag gagaatgcct ggcagataat 1201 aagtgtttaa tacatgaaac tgatttttat tactgttatt aaaaaatatt tagaacacca 1261 actccctgaa tacaacagaa aatgattcag ggcaacagac agaggagaat gttctctcct 1321 tgaggaagca actggatctt gtcatcactg tatacctacc taccccaccc cctccccagc 1381 tcagtgcctg gctcacagta ggctttcagt taccctctgc agatcagtga aagctaggtg 1441 agtgcccgga gtgaagaaaa gttggcaggt ttcccactga taccagctgc tgttggtttc 1501 tgaacactca aagccgcaaa taccttaggg ctgggggcaa tgaacccaag gctgaattcc 1561 aagttcagaa gcagcgaagt ctgaatttag aacctaggac ttaaactgct gcaggtccaa 1621 cttcaagccc cagttttaga cagaggcttg ggaaagatct gacttctaac ccggttcccc 1681 ctcccctcct cccctcgatg cttctcacag gaaagtacac ctggtcctgc caaatcgcac 1741 tcttatatcc tggcatccta tccaggctct gcgaggatgg aaactgcgag gcaggggagg 1801 gaagcgggct gtttggccac cacctcccta gtgctgcagg cgaccctgtc acactaaact 1861 cctggcagcc cagtgaggtg gacggcaccg ccccacctgc agatgaggga aatgaagctc 1921 ggaggagttc cgtgatttgc ttgcttcaca ctgtggtagc ctggccacga aagaaccaag 1981 gattccgact tcggattctt ccaccacaca ctttcgtcct aagggtgggg gcggggggag 2041 aataaaataa ccgcggaaaa ggaaccactt acatgtgtct agcgcttcct agaggctacc 2101 caggatatgc gcccaccacc cggccggagt gcagagattt gaagtccagg ttctaccccg 2161 ggctccgagt actactgcgt gactttatgc gagtgtcgcc gccttctggg cttgttttcc 2221 cggaagcaac tcggcgcgga tggagtgtgt gtgtgcgcgc gcgcgttatg ttgtgcgtgt 2281 tgtgttagcg tgtgcgtgtt gtccgagttt cggatcgcct acacctgtga acccccgcgc 2341 cctttccccc acggtcccgg agatgaagtg gggtgcaacg gagactcagc tgagcgtcca 2401 gtttcgggca atacaaatct ctcggcttct acgagcagcc acacgacccc gcggaccgtc 2461 gctcctgaac ttgaccgaga tgcaaacttc ggagtgttct caacgtgggg gccgactctc 2521 ggagaccgcc ctaaacttaa gtccccttag gctcgcccca cctggacttc acatagccac 2581 cttaagggcg gtattcccgc ccccggaagt gcgggtggca gcgtacttgg attctcagcc WO 00/09525 PCTIUS99/17712 EPI-109 834 2641 tccagccccg cgcggtggcg gccgcggtgg atgacttcgg gccccacaag tggaaacaac 2701 aaccacccct cgcccgcacc cctggcccaa aacaactggc caggttccct cgtcccgggt 2761 ccctgcatcc cccgcatccc cgtccgcagc cgtgaacttg agcccccctc catcagaggt 2821 tgcgagcgtc gccgctcggc agccaccgtc actagacagt caaaccccaa gacgtcagcc 2881 cacaatgcac cgggcgggcc gggaaaaacg gcccggggag gggaccgggg aacagagggc 2941 cgagaggcgt gcggcagggg ggagggtagq agaaagaagg gcccgactgt aggagggcag 3001 cggagcatta cctcatcccg tgagcctccg cgggcccaga gaagaatctt ctagggtgga 3061 gtctccatgg tgacgggcgg gcccgccccc ctgagagcga cgcgagccaa tgggaaggcc 3121 ttggggtgac atcatgggct atttttaggg gttgactggt agcagataag tgttgagctc 3181 gggctggata agggctca 1 cccggggagg ggaccgggga acagagggcc gagaggcgtg cggcaggggg gagggtagga 61 gaaagaaggg cccgactgta ggagggcagc ggagcattac ctcatcccgt gagcctccgc 121 gggcccagag aagaatcttc tagggtggag tctccatggt gacgggcggg cccgcccccc 181 tgagagcgac gcgagccaat gggaaggcct tggggtgaca tcatgggcta tttttagggg 241 ttgactggta gcagataagt gttgagctcg ggctggataa gggctcagag ttgcactgag 301 tgtggctgaa gcagcgaggc gggagtggag gtgcgcggag tcaggcagac agacagacac 361 agccagccag ccaggtcggc agtatagtcc gaactgcaaa tcttattttc ttttcacctt 421 ctctctaact gcccagagct agcgcctgtg gctcccgggc tggtggttcg ggagtgtcca 481 gagagccttg tctccagccg gccccgggag gagagccctg ctgcccaggc gctgttgaca 541 gcggcggaaa gcagcggtac cccacgcgcc cgccggggga cgtcggcgag cggctgcagc 601 agcaaagaac tttcccggcg gggaggaccg gagacaagtg gcagagtccc ggagcgaact 661 tttgcaagcc tttcctgcgt cttaggcttc tccacggcgg taaagaccag aaggcggcgg 721 agagccacgc aagagaagaa ggacgtgcgc tcagcttcgc tcgcaccggt tgttgaactt 781 gggcgagcgc gagccgcggc tgccgggcgc cccctccccc tagcagcgga ggaggggaca 841 agtcgtcgga gtccgggcgg ccaagacccg ccgccggccg gccacgcag ggtccgcact 901 gatccgctcc gcggggagag ccgctgctct gggaagtgag ttcgcctgcg gactccgagg 961 aaccgctgcg cccgaagagc gctcagtgag tgaccgcgac ttttcaaagc cgggtagcgc 1021 gcgcgagtcg acaagtaaga gtgcgggagg catcttaatt aaccctgcgc tccctggagc 1081 gagctggtga ggagggcgca gcggggacga cagccagcgg gtgcgtgcgc tcttagagaa 1141 actttccctg tcaaaggctc cggggggcgc gggtgtcccc cgcttgccag agccctgttg 1201 cggccccgaa acttgtgcgc gcacgccaaa ctaacctcac gtgaagtgac ggactgttct 1261 atgactgcaa agatggaaac gaccttctat gacgatgccc tcaacgcctc gttcctcccg 1321 tccgagagcg gaccttatgg ctacagtaac cccaagatcc tgaaacagag catgaccctg 1381 aacctggccg acccagtggg gagcctgaag ccgcacctcc gcgccaagaa ctcggacctc 1441 ctcacctcgc ccgacgtggg gctgctcaag ctggcgtcgc ccgagctgga gcgcctgata 1501 atccagtcca gcaacgggca catcaccacc acgccgaccc ccacccagtt cctgtgcccc 1561 aagaacgtga cagatgagca ggaggggttc gccgagggct tcgtgcgcgc cctggccgaa 1621 ctgcacagcc agaacacgct gcccagcgtc acgtcggcgg cgcagccggt caacggggca 1681 ggcatggtgg ctcccgcggt agcctcggtg gcagggggca gcggcagcgg cggcttcagc 1741 gccagcctgc acagcgagcc gccggtctac gcaaacctca gcaacttcaa cccaggcgcg 1801 ctgagcagcg gcggcggggc gccctcctac ggcgcggccg gcctggcctt tcccgcgcaa 1861 ccccagcagc agcagcagcc gccgcaccac ctgccccagc agatgcccgt gcagcacccg 1921 cggctgcagg ccctgaagga ggagcctcag acagtgcccg agatgcccgg cgagacaccg 1981 cccctgtccc ccatcgacat ggagtcccag gagcggatca aggcggagag gaagcgcatg 2041 aggaaccgca tcgctgcctc caagtgccga aaaaggaagc tggagagaat cgcccggctg 2101 gaggaaaaag tgaaaacctt gaaagctcag aactcggagc tggcgtccac ggccaacatg 2161 ctcagggaac aggtggcaca gcttaaacag aaagtcatga accacgttaa cagtgggtgc 2221 caactcatgc taacgcagca gttgcaaaca ttttgaagag agaccgtcgg gggctgaggg 2281 gcaacgaaga aaaaaaataa cacagagaga cagacttgag aacttgacaa gttgcgacgg 2341 agagaaaaaa gaagtgtccg agaactaaag ccaagggtat ccaagttgga ctgggttcgg 2401 tctgacggcg cccccagtgt gcacgagtgg gaaggacttg gtcgcgccct cccttggcgt 2461 ggagccaggg agcggccgcc tgcgggctgc cccgctttgc ggacgggctg tccccgcgcg 2521 aacggaacgt tggactttcg ttaacattga ccaagaactg catggaccta acattcgatc 2581 tcattcagta ttaaaggggg gagggggagg gggttacaaa ctgcaataga gactgtagat 2641 tgcttctgta gtactcctta agaacacaaa gcggggggag ggttggggag gggcggcagg 2701 agggaggttt gtgagagcga ggctgagcct acagatgaac tctttctggc ctgctttcgt 2761 taactgtgta tgtacatata tatatttttt aatttgatta aagctgatta ctgtcaataa 2821 acagcttcat gcctttgtaa gttatttctt gtttgtttgt ttgggtatcc tgcccagtgt 2881. tgtttgtaaa taagagattt ggagcactct gagtttacca tttgtaataa agtatataat 2941 ttttttatgt tttgtttctg aaaattccag aaaggatatt taagaaaata caataaacta 3001 ttggaaagta ctcccctaac ctcttttctg catcatctgt agatcctagt ctatctaggt 3061 ggagttgaaa gagttaaaaa tgctcgataa aatcactctc agtgcttctt actattaagc 3121 agtaaaaact gttctctatt agacttagaa ataaatgtac ctgatgtacc tgatgctatg 3181 tcaggcttca tactccacgc tcccccagcg tatctatatg gaattgctta ccaaaggcta 3241 gtgcgatgtt tcaggaggct ggaggaaggg gggttgcagt ggagagggac agcccactga 3301 gaagtcaaac atttcaaagt ttggattgca tcaagtggca tgtgctgtga ccatttataa 3361 tgttagaaat tttacaatag gtgcttattc tcaaagcagg aattggtggc agattttaca 3421 aaagatgtat ccttccaatt tggaatcttc tctttgacaa ttcctagata aaaagatggc WO 00/09525 PCT/US99/17712 EPI-109 835 3481 ctttgtctta tgaatattta taacagcatt ctgtcacaat aaatgtattc aaataccaat 3541 aacagatctr gaattgcttc cctttactac ttttttgttc ccaagttata tactgaagtt 3601 tttattttta gttgctgagg tt (2) INFORMATION FOR SEQ ID NO:2663: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2663 1 cggccccaga aaacccgagc gagtaggggg cggcgcgcag gagggaggag aactgggggc 61 gcgggaggct ggtgggtgtc gggggtggag atgtagaaga tgtgacgccg cggcccggcg 121 ggtgccagat tagcggacgg ctgcccgcgg ttgcaacggg atcccgggcg ctgcagcttg 181 ggaggcggct ctccccaggc ggcgtccgcg gagacaccca tccgtgaacc ccaggtcccg 241 ggccgccggc tcgccgcgca ccaggggccg gcggacagaa gagcggccga gcggctcgag 301 gctgggggac cgcgggcgcg gccgcgcgct gccgggcggg aggctggggg gccggggccg 361 gggccgtgcc ccggagcggg tcggaggccg gggccggggc cgggggacgg cggctccccg 421 cgcggctcca gcggctcggg gatcccggcc gggccccgca gggaccatgg cagccgggag 481 catcaccacg ctgcccgcct tgcccgagga tggcggcagc ggcgccttcc cgcccggcca 541 cttcaaggac cccaagcggc tgtactgcaa aaacgggggc ttcttcctgc gcatccaccc 601 cgacggccga gttgacgggg tccgggagaa gagcgaccct cacatcaagc tacaacttca 661 agcagaagag agaggagttg tgtctatcaa aggagtgtgt gctaaccgtt acctggctat 721 gaaggaagat ggaagattac tggcttctaa atgtgttacg gatgagtgtt tcttttttga 781 acgattggaa tctaataact acaatactta ccggtcaagg aaatacacca gttggtatgt 841 ggcactgaaa cgaactgggc agtataaact tggatccaaa acaggacctg ggcagaaagc 901 tatacttttt cttccaatgt ctgctaagag ctgattttaa tggccacatc taatctcatt 961 tcacatgaaa gaagaagtat attttagaaa tttgttaatg agagtaaaag aaaataaatg 1021 tgtatagctc agtttggata attggtcaaa caatttttta tccagtagta aaatatgtaa 1081 ccattgtccc agtaaagaaa aataacaaaa gttgtaaaat gtatattctc ccttttatat 1141 tgcatctgct gttacccagt gaagcttacc tagagcaatg atctttttca cgcatttgct 1201 ttattcgaaa agaggctttt aaaatgtgca tgtttagaaa caaaatttct tcatggaaat 1261 catatacatt agaaaatcac agtcagatgt ttaatcaatc caaaatgtcc actatttctt 1321 atgtcattcg ttagtctaca tgtttctaaa catataaatg tgaatttaat caattccttt 1381 catagtttta taattctctg gcagttcctt atgatagagt ttataaaaca gtcctgtgta 1441 aactgctgga agttcttcca cagtcaggtc aattttgtca aacccttctc tgtacccata 1501 cagcagcagc ctagcaactc tgctggtgat gggagttgta ttttcagtct tcgccaggtc 1561 attgagatcc atccactcac atcttaagca ttcttcctgg caaaaattta tggtgaatga 1621 atatggcttt aqgcggcaga tgatatacat atctgacttc ccaaaagctc caggatttgt 1681 gtgctgttgc cgaatactca ggacggacct gaattctgat tttataccag tctcttcaaa 1741 aacttctcga accgctgtgt ctcctacgta aaaaaagaga tgtacaaatc aataataatt 1801 acacttttag aaactgtatc atcaaagatt ttcagttaaa gtagcattat gtaaaggctc 1861 aaaacattac cctaacaaag taaagttttc aatacaaatt ctttgccttg tggatatcaa 1921 gaaatcccaa aatattttct taccactgta aattcaagaa gcttttgaaa tgctgaatat 1981 ttctttggct gctacttgga ggcttatcta cctgtacatt tttggggtca gctcttttta 2041 acttcttgct gctctttttc ccaaaaggta aaaatataga ttgaaaagtt aaaacatttt 2101 gcatggctgc agttcctttg tttcttgaga taagattcca aagaacttag attcatttct 2161 tcaacaccga aatgctggag gtgtttgatc agttttcaag aaacttggaa tataaataat 2221 tttataattc aacaaaggtt ttcacatttt ataaggttga tttttcaatt aaatgcaaat 2281 ttgtgtggca ggatttttat tgccattaac atatttttgt ggctgctttt tctacacatc 2341 cagatggtcc ctctaactgg gctttctcta attttgtgat gttctgtcat tgtctcccaa 2401 agtatttagg agaagccctt taaaaagctg ccttcctcta ccactttgct ggaaagcttc 2461 acaattgtca cagacaaaga tttttgttcc aatactcgtt ttgcctctat ttttcttgtt 2521 tgtcaaatag taaatgatat ttgcccttgc agtaattcta ctggtgaaaa acatgcaaag 2581 aagaggaagt cacagaaaca tgtctcaatt cccatgtgct gtgactgtag actgtcttac 2641 catagactgt cttacccatc ccctggatat gctcttgttt tttccctcta atagctatgg 2701 aaagatgcat agaaagagta taatgtttta aaacataagg cattcatctg ccatttttca 2761 attacatgct gacttccctt acaattgaga tttgcccata ggttaaacat ggttagaaac 2821 aactgaaagc ataaaagaaa aatctaggcc gggtgcagtg gctcatgcct atattccctg 2881 cactttggga ggccaaagca ggaggatcgc ttgagcccag gagttcaaga ccaacctggt 2941 gaaaccccgt ctctacaaaa aaacacaaaa aatagccagg catggtggcg tgtacatgtg 3001 gtctcagata cttgggaggc tgaggtggga gggttgatca cttgaggctg agaggtcaag 3061 gttgcagtga gccataatcg tgccactgca gtccagccta ggcaacagag tgagactttg 3121 tctcaaaaaa agagaaattt tccttaataa gaaaagtaat ttttactctg atgtgcaata 3181 catttgttat taaatttatt atttaagatg gtagcactag tcttaaattg tataaaatat 3241 cccctaacat gtttaaatgt ccatttttat icattatgct ttgaaaaata attatgggga 3301 aatacatgtt tgttattaaa tttattatta aagatagtag cactagtctt aaatttgata 3361 taacatctcc taacttgttt aaatgtccat ttttattctt tatgcttgaa aataaattat 3421 ggggatccta tttagctctt agtaccacta atcaaaagtt cggcatgtag ctcatgatct WO 00/09525 PCT/US99/17712 EPI-109 836 3481 atgctgtttc tatgtcgtgg aagcaccgga tgggggtagt gagcaaatct gccctgctca 3541 gcagtcacca tagcagctga ctgaaaatca gcactgcctg agtagttttg atcagtttaa 3601 cttgaatcac taactgactg aaaattgaat gggcaaataa gtgcttttgt ctccagagta 3661 tgcgggagac ccttccacct caagatggat atttcttccc caaggatttc aagatgaatt 3721 gaaattttta atcaagatag tgtgctttat tctgttgtat tttttattat tttaatatac 3781 tgtaagccaa actgaaataa catttgctgt tttataggtt tgaagaacat aggaaaaact 3841 aagaggtttt gtttttattt ttgctgatga agagatatgt ttaaatatgt tgtattgttt 3901 tgtttagtta caggacaata atgaaatgga gtttatattt gttatttcta ttttgttata 3961 tttaataata gaattagatt gaaataaaat ataatgggaa ataatctgca gaatgtgggt 4021 ttcctggtgt ttcctctgac tctagtgcac tgatgatctc tgataaggct cagctgcttt 4081 atagttctct ggctaatgca gcagatactc ttcctgccag tggtaatacg attttttaag 4141 aaggcagttt gtcaatttta atcttgtgga tacctttata ctcttagggt attattttat 4201 acaaaagcct tgaggattgc attctatttt ctatatgacc ctcttgatat ttaaaaaaca 4261 ctatggataa caattcttca tttacctagt attatgaaag aatgaaggag ttcaaacaaa 4321 tgtgtttccc agttaactag ggtttactgt ttgagccaat ataaatgttt aactgtttgt 4381 gatggcagta ttcctaaagt acattgcatg ttttcctaaa tacagagttt aaataatttc 4441 agtaattctt agatgattca gcttcatcat taagaatatc ttttgtttta tgttgagtta 4501 gaaatgcctt catatagaca tagtctttca gacctctact gtcagttttc atttctagct 4561 gctttcaggg ttttatgaat tttcaggcaa agctttaatt tatactaagc ttaggaagta 4621 tggctaatgc caacggcagt ttttttcttc ttaattccac atgactgagg catatatgat 4681 ctctgggtag gtgagttgtt gtgacaacca caagcacttt tttttttttt aaagaaaaaa 4741 aggtagtgaa tttttaatca tctggacttt aagaaggatt ctggagtata cttaggcctg 4801 aaattatata tatttggctt ggaaatgtgt ttttcttcaa ttacatctac aagtaagtac 4861 agctgaaatt cagaggaccc ataagagttc acatgaaaaa aatcaattca tttgaaaagg 4921 caagatgcag gagagaggaa gccttgcaaa cctgcagact gctttttgcc caatatagat 4981 tgggtaaggc tgcaaaacat aagcttaatt agctcacatg ctctgctctc acgtggcacc 5041 agtggatagt gtgagagaat taggctgtag aacaaatggc cttctctttc agcattcaca 5101 ccactacaaa atcatctttt atatcaacag aagaataagc ataaactaag caaaaggtca 5161 ataagtacct gaaaccaaga ttggctagag atatatctta atgcaatcca ttttctgatg 5221 gattgttacg agttggctat ataatgtatg tatggtattt tgatttgtgt aaaagtttta 5281 aaaatcaagc tttaagtaca tggacatttt taaataaaat atttaaagac aatttagaaa 5341 attgccttaa tatcattgtt ggctaaatag aataggggac atgcatatta aggaaaaggt 5401 catggagaaa taatattggt atcaaacaaa tacattgatt tgtcatgata cacattgaat 5461 ttgatccaat agtttaagga ataggtagga aaatttggtt tctatttttc gatttcctgt 5521 aaatcagtga cataaataat tcttagctta ttttatattt ccttgtctta aatactgagc 5581 tcagtaagtt gtgttagggg attatttctc agttgagact ttcttatatg acattttact 5641 atgttttgac ttcctgacta ttaaaaataa atagtagaaa caattttcat aaagtgaaga 5701 attatataat cactgcttta taactgactt tattatattt atttcaaagt tcatttaaag 5761 gctactattc atcctctgtg atggaatggt caggaatttg ttttctcata gtttaattcc 5821 aacaacaata ttagtcgtat ccaaaataac ctttaatgct aaactttact gatgtatatc 5881 caaagcttct ccttttcaga cagattaatc cagaagcagt cataaacaga agaataggtg 5941 gtatgttcct aatgatatta tttctactaa tggaataaac tgtaatatta gaaattatgc 6001 tgctaattat atcagctctg aggtaatttc tgaaatgttc agactcagtc ggaacaaatt 6061 ggaaaattta aatttttatt cttagctata aagcaagaaa gtaaacacat taatttcctc 6121 aacattttta agccaattaa aaatataaaa gatacacacc aatatcttct tcaggctctg 6181 acaggcctcc tggaaacttc cacatatttt tcaactgcag tataaagtca gaaaataaag 6241 ttaacataac tttcactaac acacacatat gtagatttca caaaatccac ctataattgg 6301 tcaaagtggt tgagaatata ttttttagta attgcatgca aaatttttct agcttccatc 6361 ctttctccct cgtttcttct ttttttgggg gagctggtaa ctgatgaaat cttttcccac 6421 cttttctctt caggaaatat aagtggtttt gtttggttaa cgtgatacat tctgtatgaa 6481 tgaaacattg gagggaaaca tctactgaat ttctgtaatt taaaatattt tgctgctagt 6541 taactatgaa cagatagaag aatcttacag atgctgctat aaataagtag aaaatataaa 6601 tttcatcact aaaatatgct attttaaaat ctatttccta tattgtattt ctaatcagat 6661 gtattactct tattatttct attgtatgtg ttaatgattt tatgtaaaaa tgtaattgct 6721 tttcatgagt agtatgaata aaattgatta gtttgtg (2) INFORMATION FOR SEQ ID NO:2664: (i) SEQUENCE CHARACTERISTICS: .(A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2664 1 cagtgagctg tgattgcacc actgcaattt agcctgagtg acagaatgaa aaaaaaattt 61 ttttaaagga aaacacaaaa agaatatgct gtcaacaggg atgggaggaa gaccaccttt 121 actgctatac acatttgtac cttttagatg ttgatcaata tgaatatatt atacacacag 181 acacacacac agacacacac acacacacaa acaatacaat ttaatatcct aagaggatat 241 tgacattaga caggtacaaa agctctagaa atgaggactt tcctcagtga tgactttttt 301 caccaccaaa gtcactcagg catcctgaca agggtaagtg aggggagcct ccttggaaaa WO 00/09525 PCT/US99/17712 EPI-109 837 361 taaactcact tggatacga actcctgcac atacctcaaa gcccatctga aatgtcccct 421 cctacaggaa gttttccotg accctccaag aagcagagtt ctatttcact ggggaaaaca 481 tttcttcttc ttcttttttt tccctgccct gcacatgagc tagaaaacat ttcatgaaac 541 tgggagtttc tgtgctaggc tctgtccctc ccccattcta cttcccctcc ctcagcatgg 601 aagcctctgg aagtggggct ctgactccca gcctacagag agattcctag gaagtgttcg 661 actgataaac gcatggccaa aagtgaactg gggatgaggt ccaagacatc tgcggtgggg 721 ggttctccag accttagtgt tcttccacta caaagtgggt ccaacagaga aaggtctgtg 781 ttcaccaggt ggccctgacc ctgggagagt ccagggcagg gtgcagctgc attcatgctg 841 ctggggaaca tgccctcagg ttactcaccc catggacatg ttggccccag ggactgaaaa 901 gcttaggaaa tggtattgag aaatctgggg cagccccaaa aggggagagg ccatggggag 961 aagggggggc tgagtggggg aaaggcagga gccagataaa aagccagctc cagcaggcgc 1021 tgctcactcc tccccatcct ctccctctgt ccctctgtcc ctctgaccct gcactgtccc 1081 agcaccatg (2) INFORMATION FOR SEQ ID NO:2665: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: _base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2665 1 tttctcccat tctacttccc tcctcagcat tggaagctcg taagtgggct ctgactccca 61 gcctacagag agattccta agaagtggtt cgactgataa acgcattgcc aaaagtgaac 121 tgggatgagg tccaagacat ctgcggtggg ggttctccag accttagtgt tcttccacta 181 caaagtgggt ccaacagaga aaggtctgtg ttcaccagg ggccctgacc ctggagagtc 241 cagggcaggg tgcagctgca ttcatgctgc tggggaacat gccctcaggt tactcacccc 301 atgacatgtt ggccccaggg actgaaaagc ttaggaaatg gtattgagaa atctggggca 361 gccaaaaggg gagaggccat ggggagaagg gggggctgag tgggggaaag caggagcgag 421 ataaaaagcc agctccagca ggcgctgctc actcctcccc atcctctccc tctgtccctc 481 tgtccctctg accctgcacc gtcccagcac catgggaccc acctcaggtc ccagcctgct 541 gctcctgcta ctaacccacc tccccctggc tctggggagt cccatgtact ctatcatcac 601 ccccaacatc ttgcggctgg agagcgagga gaccatggtg ctggaggccc acgacgcgca 661 aggggatgtt ccagtcactg ttactgtcca cgacttccca ggcaaaaaac tagtgctgtc 721 cagtgagaag actgtgctga cccctgccac caaccacatg ggcaacgtca ccttcacgat 781 cccagccaac agggagttca agtcagaaaa ggggcgcaac aagttcgtga ccgtgcaggc 841 caccttcggg acccaagtgg tggagaaggt ggtgctggtc agcctgcaga gcgggtacct 901 cttcatccag acagacaaga ccatctacac ccctggctcc acagttctct atcggatctt 961 caccgtcaac cacaagctgc tacccqtggg ccggacggtc atggtcaaca ttgagaaccc 1021 ggaaggcatc ccggtcaagc aggactcctt gtcttctcag aaccagcttg gcgtcttgcc 1081 cttgtcttgg gacattccgg aactcgtcaa catgggccag tggaagatcc gagcctacta 1141 tgaaaactca ccacagcagg tcttctccac tgagtttgag gtgaaggagt acgtgctgcc 1201 cagtttcgag gtcatagtgg agcctacaga gaaattctac tacatctata acgagaaggg 1261 cctggaggtc accatcaccg ccaggttcct ctacgggaag aaagtggagg gaactgcctt 1321 tgtcatcttc gggatccagg atggcgaaca gaggatttcc ctgcctgaat ccctcaagcg 1381 cattccgatt gaggatggct cgggggaggt tgtgctgagc cggaaggtac tgctggacgg 1441 ggtgcagaac ctccgagcag aagacctggt ggggaagtct ttgtacgtgt ctgccaccgt 1501 catcttgcac tcaggcagtg acatggtgca ggcagagcgc agcgggatcc ccatcgtgac 1561 ctctccctac cagatccact tcaccaagac acccaagtac ttcaaaccag gaatgccctt 1621 tgacctcatg gtgttcgtga cgaaccctga tggctctcca gcctaccgag tccccgtggc 1681 agtccagggc gaggacactg tgcagtctct aacccaggga gatggcgtgg ccaaactcag 1741 catcaacaca caccccagcc agaagccctt gagcatcacg gtgcgcacga agaagcagga 1801 gctctcggag gcagagcagg ctaccaggac catgcaggct ctgccctaca gcaccgtggg 1861 caactccaac aattacctgc atctctcagt gctacgtaca gagctcagac ccggggagac 1921 cctcaacgtc aacttcctcc tgcgaatgga ccgcgcccac gaggccaaga tccgctacta 1981 cacctacctg atcatgaaca agggcaggct gttgaaggcg ggacgccagg tgcgagagcc 2041 cggccaggac ctggtggcgc tgcccctgtc catcaccacc gacttcatcc cttccttccg 2101 cctggtggcg tactacacgc tgatcggtgc cagcggccag agggaggtgg tggccgactc 2161 cgtgtgggtg gacgtcaagg actcctgcgt gggctcgctg gtggtaaaaa gcggccagtc 2221 agaagaccgg cagcctgtac ctgggcagca gatgaccctg aagatagagg gtgaccacgg 2281 ggcccgggtg gtactggtgg ccgtgqacaa gggcgtgttc gtgctgaata agaagaacaa 2341 actgacgcag agtaagatct gggacgtggt ggagaaggca gacatcggct gcaccccggg 2401 cagtgggaag gattacgccg gtgtcttctc cgacgcaggg ctgaccttca cgagcagcag 2461 tggccagcag accgcccaga gggcagaact tcagtgcccg cagccagccg cccgccgacg 2521 ccgttccgtg cagctcacgg agaagcgaat ggacaaagtc ggcaagtacc ccaaggagct 2581 gcgcaagtgc tgcgaggacg gcatgcggga gaaccccatg aggttctcgt gccagcgccg 2641 gacccgtttc atctccctgg gcgaggcgtg caagaaggtc ttcctggact gctgcaacta 2701 catcacagag ctgcggcggc agcacgcgcg ggccagccac ctgggcctgg ccaggagtaa 2761 cctggatgag gacatcattg cagaagagaa cat cgtt cc cgaagtgagt tcccagagag 2821 ctggctgtgg aacgttgagg acttgaaaga gccaccgaaa aatggaatct ctacgaagct WO 00/09525 PCT/US99/17712 EPI-109 838 2881 catgaatata tttttgaaag actccatcac cacgtgggag attctagctg tcagcatgtc 2941 ggacaagaaa gggatctgtg tggcagaccc cttcgaggtc acagtaatgc aggacttctt 3001 catcgacctg cggctaccct actctgttgt tcgaaacgag caggtggaaa tccgagccgt 3061 tctctacaat taccggcaga accaagagct caaggtgagg gtggaactac tccacaatcc 3121 agccttctgc agcctggcca ccaccaagag gcgtcaccag cagaccgtaa ccatcccccc 3181 caagtcctcg ttgtccgttc catatgtcat cgtgccgcta aagaccggcc tgcaggaagt 3241 ggaagtcaag gctgccgtct accatcattt catcagtgac ggtgtcagga agtccctgaa 3301 ggtcgtgccg gaaggaatca gaatgaacaa aactgtggct gttcgcaccc tggatccaga 3361 acgcctgggc cgtgaaggag tgcagaaaga ggacatccca cctgcagacc tcagtgacca 3421 agtcccggac accgagtctg agaccagaat tctcctgcaa gggaccccag tggcccagat 3481 gacagaggat gccgtcgacg cggaacggct gaagcacctc attgtgaccc cctcgggctg 3541 cggggaacaa aacatgatcg gcatgacgcc cacggtcatc gctgtgcatt acctggatga 3601 aacggagcag tgggagaagt tcggcctaga gaagcggcag ggggccttgg agctcatcaa 3661 gaaggggtac acccagcagc tggccttcag acaacccagc tctgcctttg cggccttcgt 3721 gaaacgggca cccagcacct ggctgaccgc ctacgtggtc aaggtcttct ctctggctgt 3781 caacctcatc gccatcgact cccaagtcct ctgcggggct gttaaatggc tgatcctgga 3841 gaagcagaag cccgacgggg tcttccagga ggatgcgccc gtgatacacc aagaaatgat 3901 tggtggatta cggaacaaca acgagaaaga catggccctc acggcctttg ttctcatctc 3961 gctgcaggag gctaaagata tttgcgagga gcaggtcaac agcctgccag gcagcatcac 4021 taaagcagga gacttccttg aagccaacta catgaaccta cagagatcct acactgtggc 4081 cattgctggc tatgctctgg cccagatggg caggctgaag gggcctcttc ttaacaaatt 4141 tctgaccaca gccaaagata agaaccgctg ggaggaccct ggtaagcagc tctacaacgt 4201 ggaggccaca tcctatgccc tcttggccct actgcagcta aaagactttg actttgtgcc 4261 tcccgtcgtg cgttggctca atgaacagag atactacggt ggtggctatg gctctaccca 4321 ggccaccttc atggtgttcc aagccttggc tcaataccaa aaggacgccc ctgaccacca 4381 ggaactgaac cttgatgtgt ccctccaact gcccagccgc agctccaaga tcacccaccg 4441 tatccactgg gaatctgcca gcctcctgcg atcagaagag accaaggaaa atgagggttt 4501 cacagtcaca gctgaaggaa aaggccaagg caccttgtcg gtggtgacaa tgtaccatgc 4561 taaggccaaa gatcaactca cctgtaataa attcgacctc aaggtcacca taaaaccagc 4621 accggaaaca gaaaagaggc ctcaggatgc caagaacact atgatccttg agatctgtac 4681 caggtaccgg ggagaccagg atgccactat gtctatattg gacatatcca tgatgactgg 4741 ctttgctcca gacacagatg acctgaagca gctggccaat ggtgttgaca gatacatctc 4801 caagtatgag ctggacaaag ccttctccga taggaacacc ctcatcatct acctggacaa 4861 ggtctcacac tctgaggatg actgtctagc tttcaaagtt caccaatact ttaatgtaga 4921 gcttatccag cctggagcag tcaaggtcta cgcctattac aacctggagg aaagctgtac 4981 ccggttctac catccggaaa aggaggatgg aaagctgaac aagctctgcc gtgatgaact 5041 gtgccgctgt gctgaggaga attgcttcat acaaaagtcg gatgacaagg tcaccctgga 5101 agaacggctg gacaaggcct gtgagccagg agtggactat gtgtacaaga cccgactggt 5161 caaggttcag ctgtccaatg actttgacga gtacatcatg gccattgagc agaccatcaa 5221 gtcaggctcg gatgaggtgc aggttggaca gcagcgcacg ttcatcagcc ccatcaagtg 5281 cagagaagcc ctgaagctgg aggagaagaa acactacctc atgtggggtc tctcctccga 5341 tttctgggga gagaagccca acctcagcta catcatcggg aaggacactt gggtggagca 5401 ctggcctgag gaggacgaat gccaagacga agagaaccag aaacaatgcc aggacctcgg 5461 cgccttcacc gagagcatgg ttgtctttgg gtgccccaac tgaccacacc cccattccat 5521 gaacctacag agatcctaca ctgtggccat tgctggctat gctctggccc agatgggcag 5581 gctgaagggg cctcttctta acaaatttct gaccacagcc aaagataaga accgctggga 5641 ggaccctggt aagcagctct acaacgtgga ggccacatcc tatgccctct tggccctact 5701 gcagctaaaa gactttgact ttgtgcctcc cgtcgtgcgt tggctcaatg aacagagata 5761 ctacggtggt ggctatggct ctacccaggc caccttcatg gtgttccaag ccttggctca 5821 ataccaaaag gacgcccctg accaccagga actgaacctt gatgtgtccc tccaactgcc 5881 cagccgcagc tccaagatca cccaccgtat ccactgggaa tctgccagcc tcctgcgatc 5941 agaagag (2) INFORMATION FOR SEQ ID- NO:2666: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2666 1 ctcctcccca tcctctccct ctgtccctct gtccctctga ccctgcactg tcccagcacc 61 atgggaccca cctcaggtcc cagcctgctg ctcctgctac taacccacct ccccctggct 121 ctggggagtc ccatgtactc tatcatcacc cccaacatct tgcggctgga gagcgaggag 181 accatggtgc tggaggccca cgacgcgcaa ggggatgttc cagtcactgt tactgtccac 241 gacttcccag gcaaaaaact agtgctgtcc agtgagaaga ctgtgctgac ccctgccacc 301 aaccacatgg gcaacgtcac cttcacgatc ccagccaaca gggagttcaa gtcagaaaag 361 gggcgcaaca agttcgtgac cgtgcaggcc accttcggga cccaagtggt ggagaaggtg 421 gtgctggtca gcctgcagag cgggtacctc ttcatccaga cagacaagac catctacacc 481 cctggctcca cagttctcta tcggatcttc accgtcaacc acaagctgct acccgtgggc WO 00/09525 PCT/US99/17712 EPI-109 839 541 cggacggtca tggtcaacat tgagaacccg gaaggcatcc cggtcaagca ggactccttg 601 tcttctcaga accagcttgg cgtcttgccc ttgtcttggg acattccgga actcgtcaac 661 atgggccagt ggaagatccg agcctactat gaaaactcac cacagcaggt cttctccact 721 gagtttgagg tgaaggagta cgtgctgccc agtttcgagg tcatagtgga gcctacagag 781 aaattctact acatctataa cgagaagggc ctggaggtca ccatcaccgc caggttcctc 841 tacgggaaga aagtggaggg aactgccttt gtcatcttcg ggatccagga tggcgaacag 901 aggatttccc tgcctgaatc cctcaagcgc attccgattg aggatggctc gggggaggtt 961 gtgctgagcc ggaaggtact gctggacggg gtgcagaacc tccgagcaga agacctggtg 1021 gggaagtctt tgtacgtgtc tgccaccgtc atcttgcact caggcagtga catggtgcag 1081 gcagagcgca gcgggatccc catcgtgacc tctccctacc agatccactt caccaagaca 1141 cccaagtact tcaaaccagg aatgcccttt gacctcatgg tgttcgtgac gaaccctgat 1201 ggctctccag cctaccgagt ccccgtggca gtccagggcg aggacactgt gcagtctcta 1261 acccagggag atggcgtggc caaactcagc atcaacacac accccagcca gaagcccttg 1321 agcatcacgg tgcgcacgaa gaagcaggag ctctcggagg cagagcaggc taccaggacc 1381 atgcaggctc tgccctacag caccgtgggc aactccaaca attacctgca tctctcagtg 1441 ctacgtacag agctcagacc cggggagacc ctcaacgtca acttcctcct gcgaatggac 1501 cgcgcccacg aggccaagat ccgctactac acctacctga tcatgaacaa gggcaggctg 1561 ttgaaggcgg gacgccaggt gcgagagccc ggccaggacc tggtggtgct gcccctgtcc 1621 atcaccaccg acttcatccc ttccttccgc ctggtggcgt actacacgct gatcggtgcc 1681 agcggccaga gggaggtggt ggccgactcc gtgtgggtgg acgtcaagga ctcctgcgtg 1741 ggctcgctgg tggtaaaaag cggccagtca gaagaccggc agcctgtacc tgggcagcag 1801 atgaccctga agatagaggg tgaccacggg gcccgggtgg tactggtggc cgtggacaag 1861 ggcgtgttcg tgctgaataa gaagaacaaa ctgacgcaga gtaagatctg ggacgtggtg 1921 gagaaggcag acatcggctg caccccgggc agtgggaagg attacgccgg tgtcttctcc 1981 gacgcagggc tgaccttcac gagcagcagt ggccagcaga ccgcccagag ggcagaactt 2041 cagtgcccgc agccagccgc ccgccgacgc cgttccgtgc agctcacgga gaagcgaatg 2101 gacaaagtcg gcaagtaccc caaggagctg cgcaagtgct gcgaggacgg catgcgggag 2161 aaccccatga ggttctcgtg ccagcgccgg acccgtttca tctccctggg cgaggcgtgc 2221 aagaaggtct tcctggactg ctgcaactac atcacagagc tgcggcggca gcacgcgcgg 2281 gccagccacc tgggcctggc caggagtaac ctggatgagg acatcattgc agaagagaac 2341 atcgtttccc gaagtgagtt cccagagagc tggctgtgga acgttgagga cttgaaagag 2401 ccaccgaaaa atggaatctc tacgaagctc atgaatatat ttttgaaaga ctccatcacc 2461 acgtgggaga ttctggctgt cagcatgtcg gacaagaaag ggatctgtgt ggcagacccc 2521 ttcgaggtca cagtaatgca ggacttcttc atcgacctgc ggctacccta ctctgttgtt 2581 cgaaacgagc aggtggaaat ccgagccgtt ctctacaatt accggcagaa ccaagagctc 2641 aaggtgaggg tggaactact ccacaatcca gccttctgca gcctggccac caccaagagg 2701 cgtcaccagc agaccgtaac catccccccc aagtcctcgt tgtccgttcc atatgtcatc 2761 gtgccgctaa agaccggcct gcaggaagtg gaagtcaagg ctgccgtcta ccatcatttc 2821 atcagtgacg gtgtcaggaa gtccctgaag gtcgtgccgg aaggaatcag aatgaacaaa 2881 actgtggctg ttcgcaccct ggatccagaa cgcctgggcc gtgaaggagt gcagaaagag 2941 gacatcccac ctgcagacct cagtgaccaa gtcccggaca ccgagtctga gaccagaatt 3001 ctcctgcaag ggaccccagt ggcccagatg acagaggatg ccgtcgacgc ggaacggctg 3061 aagcacctca ttgtgacccc ctcgggctgc ggggaacaga acatgatcgg catgacgccc 3121 acggtcatcg ctgtgcatta cctggatgaa acggagcagt gggagaagtt cggcctagag 3181 aagcggcagg gggccttgga gctcatcaag aaggggtaca cccagcagct ggccttcaga 3241 caacccagct ctgcctttgc ggccttcgtg aaacgggcac ccagcacctg gctgaccgcc 3301 tacgtggtca aggtcttctc tctggctgtc aacctcatcg ccatcgactc ccaagtcctc 3361 tgcggggctg ttaaatggct gatcctggag aagcagaagc ccgacggggt cttccaggag 3421 gatgcgcccg tgatacacca agaaatgatt ggtggattac ggaacaacaa cgagaaagac 3481 atggccctca cggcctttgt tctcatctcg ctgcaggagg ctaaagatat ttgcgaggag 3541 caggtcaaca gcctgccagg cagcatcact aaagcaggag acttccttga agccaactac 3601 atgaacctac agagatccta cactgtggcc attgctggct atgctctggc ccagatgggc 3661 aggctgaagg ggcctcttct taacaaattt ctgaccacag ccaaagataa gaaccgctgg 3721 gaggaccctg gtaagcagct ctacaacgtg gaggccacat cctatgccct cttggcccta 3781 ctgcagctaa aagactttga ctttgtgcct cccgtcgtgc gttggctcaa tgaacagaga 3841 tactacggtg gtggctatgg ctctacccag gccaccttca tggtgttcca agccttggct 3901 caataccaaa aggacgcccc tgaccaccag gaactgaacc ttgatgtgtc cctccaactg 3961 cccagccgca gctccaagat cacccaccgt atccactggg aatctgccag cctcctgcga 4021 tcagaagaga ccaaggaaaa tgagggtttc acagtcacag ctgaaggaaa aggccaaggc 4081 accttgtcgg tggtgacaat gtaccatgct aaggccaaag atcaactcac ctgtaataaa 4141 ttcgacctca aggtcaccat aaaaccagca ccggaaacag aaaagaggcc tcaggatgcc 4201 aagaacacta tgatccttga gatctgtacc aggtaccggg gagaccagga tgccactatg 4261 tctatattgg acatatccat gatgactggc tttgctccag acacagatga cctgaagcag 4321 ctggccaatg gtgttgacag atacatctcc aagtatgagc tggacaaagc cttctccgat 4381 aggaacaccc tcatcatcta cctggacaag gtctcacact ctgaggatga ctgtctagct 4441 ttcaaagttc accaatactt taatgtagag cttatccagc ctggagcagt caaggtctac 4501 gcctattaca acctggagga aagctgtacc cggttctacc atccggaaaa ggaggatgga 4561 aagctgaaca agctctgccg tgatgaactg tgccgctgtg ctgaggagaa ttgcttcata WO 00/09525 PCT/US99/17712 EPI-109 840 4621 caaaagtcgg atgacaaagt caccctggaa gaacggctgg acaaggcctg tgagccagga 4681 gtggactatg tgtacaagac ccgactggtc aaggttcagc tgtccaatga ctttgacgag 4741 tacatcatgg ccattgagca gaccatcaag tcaggctcgg atgaggtgca ggttggacag 4801 cagcgcacgt tcatcagccc catcaagtgc agagaagccc tgaagctgga ggagaagaaa 4861 cactacctca tgtgggcct ctcctccgat ttctggggag agaagcccaa cctcagctac 4921 atcatcggga aggacactg ggtggagcac tggcctgagg aggacgaatg ccaagacgaa 4981 gagaaccaga aacaatgcca ggacccggc gcettcaccg agagcatggt tgtctttggg 5041 tgccccaact gaccacacc ccattcc (2) INFORMATION FOR SEQ !D NO:2667: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2667 1 cagtgagctg tgattacacc actgcaattt agcctgagtg acagaatgaa aaaaaaattt 61 ttttaaagga aaacacaaaa agaatatgct gtcaacaggg atgggaggaa gaccaccttt 121 actgctatac acatttgtac cttttagatg ttgatcaaa tgaatatatt atacacacag 181 acacacacac agacacacac acacacacaa acaatacaat ttaatatcct aagaggatat 241 tgacattaga caggtacaaa agctctagaa atgaggactt tcctcagtga tgactttttt 301 caccaccaaa gtcactcagg catcctgaca agggtaagtg aggggagcct ccttggaaaa 361 taaactcact tggatagtga actcctgcac atacctcaaa gcccatctga aatgtcccct 421 cctacaggaa gttttccctg accctccaag aagcagagtt ctatttcact ggggaaaaca 481 tttcttcttc ttctttt::tt tccctgccct gcacatgagc tagaaaacat ttcatgaaac 541 tgggagtttc tgtgctaggc tctgtccctc ccccattcta cttcccctcc ctcagcatgg 601 aagcctctgg aagtggggct ctgactccca gcctacagag agattcctag gaagtgttcg 661 actgataaac gcatggccaa aagtgaactg gggatgaggt ccaagacatc tgcggtgggg 721 ggttctccag accttagtgt tcttccacta caaagtgggt ccaacagaga aaggtctgtg 781 ttcaccaggt ggccctgacc ctgggagagt ccagggcagg gtgcagctgc attcatgctg 841 ctggggaaca tgccctcagg ttactcaccc catggacatg ttggccccag ggactgaaaa 901 gcttaggaaa tggtattgag aaatctgggg cagccccaaa aggggagagg ccatggggag 961 aagggggggc tgagtggggg aaaggcagga gccagataaa aagccagctc cagcaggcgc 1021 tgctcactcc tccccatcct ctccctctgt ccctctgtcc ctctgaccct gcactgtccc 1081 agcaccatg 1 tttctcccat tctacttccc tcctcagcat tggaagctcg taagtgggct ctgactccca 61 gcctacagag agattcctta agaagtggtt cgactgataa acgcattgcc aaaagtgaac 121 tgggatgagg tccaagacat ctgcggtggg ggttctccag accttagtgt tcttccacta 181 caaagtgggt ccaacagaga aaggtctgtg ttcaccaggt ggccctgacc ctggagagtc 241 cagggcaggg tgcagctgca ttcatgctgc tggggaacat gccctcaggt tactcacccc 301 atgacatgtt ggccccaggg actgaaaagc ttaggaaatg gtattgagaa: atctggggca 361 gccaaaaggg gagaggccat ggggagaagg gggggctgag tgggggaaag caggagcgag 421 ataaaaagcc agctccagca ggcgctgctc actcctcccc atcctctccc tctgtccctc 481 tgtccctctg accctgcact gtcccagcac catgggaccc acctcaggtc ccagcctgct 541 gctcctgcta ctaacccacc tccccctggc tctggggagt cccatgtact ctatcatcac 601 ccccaacatc ttgcggctgg agagcgagga gaccatggtg ctggaggccc acgacgcgca 661 aggggatgtt ccagtcactg ttactgtcca cgacttccca ggcaaaaaac tagtgctgtc 721 cagtgagaag actgtgctga cccctgccac caaccacatg ggcaacgtca ccttcacgat 781 cccagccaac agggagttca agtcagaaaa ggggcgcaac aagttcgtga ccgtgcaggc 841 caccttcggg acccaagtgg tggagaaggt ggtgctggtc agcctgcaga gcgggtacct 901 cttcatccag acagacaaga ccatctacac ccctggctcc acagttctct atcggatctt 961 caccgtcaac cacaagctgc tacccgtggg ccggacggtc atggtcaaca ttgagaaccc 1021 ggaaggcatc ccggtcaagc aggactcctt gtcttctcag aaccagcttg gcgtcttgcc 1081 cttgtcttgg gacattccgg aactcgtcaa catgggccag tggaagatcc gagcctacta 1141 tgaaaactca ccacagcagg tcttctccac tgagtttgag gtgaaggagt acgtgctgcc 1201 cagtttcgag gtcatagtgg agcctacaga gaaattctac tacatctata acgagaaggg 1261 cctggaggtc accatcaccg ccaggttcct ctacgggaag aaagtggagg gaactgcctt 1321 tgtcatcttc gggatccagg atggcgaaca gaggatttcc ctgcctgaat ccctcaagcg 1381 cattccgatt gaggatggct cgggggaggt tgtgctgagc cggaaggtac tgctggacgg 1441 ggtgcagaac ctccgagcag aagacctggt ggggaagtct ttgtacgtgt ctgccaccgt 1501 catcttgcac tcaggcagtg acatggtgca ggcagagcgc agcgggatcc ccatcgtgac 1561 ctctccctac cagatccact tcaccaagac acccaagtac ttcaaaccag gaatgccctt 1621 tgacctcatg gtgttcgtga cgaaccctga tggctctcca gcctaccgag tccccgtggc 1681 agtccagggc gaggacactg tgcagtctct aacccaggga gatggcgtgg ccaaactcag 1741 catcaacaca caccccagcc agaagccctt gagcatcacg gtgcgcacga agaagcagga 1801 gctctcggag gcagagcagg ctaccaggac catgcaggct ctgccctaca gcaccgtggg 1861 caactccaac aattacctgc atctctcagt gctacgtaca gagctcagac ccggggagac 1921 cctcaacgtc aacttcccc tgcgaatgga ccgcgcccac gaggccaaga tccgctacta 1981 cacctacctg atcatgaaca agggcaggcc gttgaaggcg ggacgccagg tgcgagaqcc WO 00/09525 PCT/US99/17712 EPI-109 841 2041 cggccaggac ctggtggtgc tgcccctgtc catcaccacc gacttcatcc cttccttccg 2101 cctggtggcg tactacacgc tgatcggtgc cagcggccag agggaggtgg tggccgactc 2161 cgtgtgggtg gacgtcaagg actcctgcgt gggctcgctg gtggtaaaaa gcggccagtc 2221 agaagaccgg cagcctgtac ctgggcagca gatgaccctg aagatagagg gtgaccacgg 2281 ggcccgggtg gtactggtgg ccgtggacaa gggcgtgttc gtgctgaata agaagaacaa 2341 actgacgcag agtaagatct gggacgtggt ggagaaggca gacatcggct gcaccccggg 2401 cagtgggaag gattacgccg gtgtcttctc cgacgcaggg ctgaccttca cgagcagcag 2461 tggccagcag accgcccaga gggcagaact tcagtgcccg cagccagccg cccgccgacg 2521 ccgttccgtg cagctcacgg agaagcgaat ggacaaagtc ggcaagtacc ccaaggagct 2581 gcgcaagtgc tgcgaggacg gcatgcggga gaaccccatg aggttctcgt gccagcgccg 2641 gacccgtttc atctccctgg gcgaggcgtg caagaaggtc ttcctggact gctgcaacta 2701 catcacagag ctgcggcggc agcacgcgcg ggccagccac ctgggcctgg ccaggagtaa 2761 cctggatgag gacatcattg cagaagagaa catcgtttcc cgaagtgagt tcccagagag 2821 ctggctgtgg aacgttgagg acttgaaaga gccaccgaaa aatggaatct ctacgaagct 2881 catgaatata tttttgaaag actccatcac cacgtgggag attctggctg tcagcatgtc 2941 ggacaagaaa gggatctgtg tggcagaccc cttcgaggtc acagtaatgc aggacttctt 3001 catcgacctg cggctaccct actctgttgt tcgaaacgag caggtggaaa tccgagccgt 3061 tctctacaat taccggcaga accaagagct caaggtgagg gtggaactac tccacaatcc 3121 agccttctgc agcctggcca ccaccaagag gcgtcaccag cagaccgtaa ccatcccccc 3181 caagtcctcg ttgtccgttc catatgtcat cgtgccgcta aagaccggcc tgcaggaagt 3241 ggaagtcaag gctgccgtct accatcattt catcagtgac ggtgtcagga agtccctgaa 3301 ggtcgtgccg gaaggaatca gaatgaacaa aactgtggct gttcgcaccc tggatccaga 3361 acgcctgggc cgtgaaggag tgcagaaaga ggacatccca cctgcagacc tcagtgacca 3421 agtcccggac accgagtctg agaccagaat tctcctgcaa gggaccccag tggcccagat 3481 gacagaggat gccgtcaacg cggaacggct gaagcacctc attgtgaccc cctcgggctg 3541 cggggaacag aacatgatcg gcatgacgcc cacggtcatc gctgtgcatt acctggatga 3601 aacggagcag tgggagaagt tcggcctaga gaagcggcag ggggccttgg agctcatcaa 3661 gaaggggtac acccagcagc tggccttcag acaacccagc tctgcctttg cggccttcgt 3721 gaaacgggca cccagcacct ggctgaccgc ctacgtggtc aaggtcttct ctctggctgt 3781 caacctcatc gccatcgact cccaagtcct ctgcggggct gttaaatggc tgatcctgga 3841 gaagcagaag cccgacgggg tcttccagga ggatgcgccc gtgatacacc aagaaatgat 3901 tggtggatta cggaacaaca acgagaaaga catggccctc acggcctttg ttctcatctc 3961 gctgcaggag gctaaagata tttgcgagga gcaggtcaac agcctgccag gcagcatcac 4021 taaagcagga gacttccttg aagccaacta catgaaccta cagagatcct acactgtggc 4081 cattgctggc tatgctctgg cccagatggg caggctgaag gggcctcttc ttaacaaatt 4141 tctgaccaca gccaaagata agaaccgctg ggaggaccct ggtaagcagc tctacaacgt 4201 ggaggccaca tcctatgccc tcttggccct actgcagcta aaagactttg actttgtgcc 4261 tcccgtcgtg cgttggctca atgaacagag atactacggt ggtggctatg gctctaccca 4321 ggccaccttc atggtgttcc aagccttggc tcaataccaa aaggacgccc ctgaccacca 4381 ggaactgaac cttgatgtgt ccctccaact gcccagccgc agctccaaga tcacccaccg 4441 tatccactgg gaatctgcca gcctcctgcg atcagaagag accaaggaaa atgagggttt 4501 cacagtcaca gctgaaggaa aaggccaagg caccttgtcg gtggtgacaa tgtaccatgc 4561 taaggccaaa gatcaactca cctgtaataa attcgacctc aaggtcacca taaaaccagc 4621 accggaaaca gaaaagaggc ctcaggatgc caagaacact atgatccttg agatctgtac 4681 caggtaccgg ggagaccagg atgccactat gtctatattg gacatatcca tgatgactgg 4741 ctttgctcca gacacagatg acctgaagca gctggccaat ggtgttgaca gatacatctc 4801 caagtatgag ctggacaaag ccttctccga taggaacacc ctcatcatct acctggacaa 4861 ggtctcacac tctgaggatg actgtctagc tttcaaagtt caccaatact ttaatgtaga 4921 gcttatccag cctggagcag tcaaggtcta cgcctattac aacctggagg aaagctgtac 4981 ccggttctac catccggaaa aggaggatgg aaagctgaac aagctctgcc gtgatgaact 5041 gtgccgctgt gctgaggaga attgcttcat acaaaagtcg gatgacaagg tcaccctgga 5101 agaacggctg gacaaggcct gtgagccagg agtggactat gtgtacaaga cccgactggt 5161 caaggttcag ctgtccaatg actttgacga gtacatcatg gccattgagc agaccatcaa 5221 gtcaggctcg gatgaggtgc aggttggaca gcagcgcacg ttcatcagcc ccatcaagtg 5281 cagagaagcc ctgaagctgg aggagaagaa acactacctc atgtggggtc tctcctccga 5341 tttctgggga gagaagccca acctcagcta catcatcggg aaggacactt gggtggagca 5401 ctggcctgag gaggacgaat gccaagacga agagaaccag aaacaatgcc aggacctcgg 5461 cgccttcacc gagagcatgg ttgtctttgg gtgccccaac tgaccacacc cccattccat 5521 gaacctacag agatcctaca ctgtggccat tgctggctat gctctagccc agatgggcag 5581 gctgaagggg cctcttctta acaaatttct gaccacagcc aaagataaga accgctggga 5641 ggaccctggt aagcagctct acaacgtgga ggccacatcc tatgccctct tggccctact 5701 gcagctaaaa gactttgact ttgtgcctcc cgtcgtgcgt tggctcaatg aacagagata 5761 ctacggtggt ggctatggct ctacccaggc caccttcatg gtgttccaag ccttggctca 5821 ataccaaaag gacgcccctg accaccagga actgaacctt gatgtgtccc tccaactgcc 5881 cagccgcagc tccaagatca cccaccgtat ccactgggaa tctgccagcc tcctgcgatc 5941 agaagag 1 ctcctcccca tcctctccct ctgtccctct gtccctctga ccctgcactg tcccagcacc 61 atgggaccca cctcaggtcc cagcctgctg ctcctgctac taacccacct ccccctggct WO 00/09525 PCT/US99/17712 EPI-109 842 121 ctggggagtc ccatgtactc tatcatcacc cccaacatct tgcggctgga gagcgaggag 181 accatggtgc tggaggccca cgacgcgcaa ggggatgttc cagtcactgt tactgtccac 241 gacttcccag gcaaaaaact agtgctgtcc agtgagaaga ctgtgctgac ccctgccacc 301 aaccacatgg gcaacgtcac cttcacgatc ccagccaaca gggagtzcaa gtcagaaaag 361 gggcgcaaca agttcgtgac cgtgcaggcc accttcggga cccaagtggt ggagaaggtg 421 gtgctggtca gcctgcagag cgggtacctc ttcatccaga cagacaagac catctacacc 481 cctggctcca cagttctcta tcggatcttc accgtcaacc acaagctgct acccgtgggc 541 cggacggtca tggtcaacat tgagaacccg gaaggcatcc cggtcaagca ggactccttg 601 tcttctcaga accagcttgg cgtcttgccc ttgtcttggg acattccgga actcgtcaac 661 atgggccagt ggaagatccg agcctactat gaaaactcac cacagcaggt cttctccact 721 gagtttgagg tgaaggagta cgtgctgccc agtttcgagg tcatagtgga gcctacagag 781 aaattctact acatctataa cgagaagggc ctggaggtca ccatcaccgc caggttcctc 841 tacgggaaga aagtggaggg aactgccttt gtcatcttcg ggatccagga tggcgaacag 901 aggatttccc tgcctgaatc cctcaagcgc attccgattg aggatggctc gggggaggtt 961 gtgctgagcc ggaaggtact gctggacggg gtgcagaacc tccgagcaga agacctggtg 1021 gggaagtctt tgtacgtgtc tgccaccgtc atcttgcact caggcagtga catggtgcag 1081 gcagagcgca gcgggatccc catcgtgacc tctccctacc agatccactt caccaagaca 1141 cccaagtact tcaaaccagg aatgcccttt gacctcatgg tgttcgtgac gaaccctgat 1201 ggctctccag cctaccgagt ccccgtggca gtccagggcg aggacactgt gcagtctcta 1261 acccagggag atggcgtggc caaactcagc atcaacacac accccagcca gaagcccttg 1321 agcatcacgg tgcgcacgaa gaagcaggag ctctcggagg cagagcaggc taccaggacc 1381 atgcaggctc tgccctacag caccgtgggc aactccaaca attacctgca tctctcagtg 1441 ctacgtacag agctcagacc cggggagacc ctcaacgtca acttcctcct gcgaatggac 1501 cgcgcccacg aggccaagat ccgctactac acctacctga tcatgaacaa gggcaggctg 1561 ttgaaggcgg gacgccaggt gcgagagccc ggccaggacc tggtggtgct gcccctgtcc 1621 atcaccaccg acttcatccc ttccttccgc ctggtggcgt actacacgct gatcggtgcc 1681 agcggccaga gggaggtggt ggccgactcc gtgtgggtgg acgtcaagga ctcctgcgtg 1741 ggctcgctgg tggtaaaaag cggccagtca gaagaccggc agcctgtacc tgggcagcag 1801 atgaccctga agatagaggg tgaccacggg gcccgggtgg tactggtggc cgtggacaag 1861 ggcgtgttcg tgctgaataa gaagaacaaa ctgacgcaga gtaagatctg ggacgtggtg 1921 gagaaggcag acatcggctg caccccgggc agtgggaagg attacgccgg tgtcttctcc 1981 gacgcagggc tgaccttcac gagcagcagt ggccagcaga ccgcccagag ggcagaactt 2041 cagtgcccgc agccagccgc ccgccgacgc cgttccgtgc agctcacgga gaagcgaatg 2101 gacaaagtcg gcaagtaccc caaggagctg cgcaagtgct gcgaggacgg catgcgggag 2161 aaccccatga ggttctcgtg ccagcgccgg acccgtttca tctccctggg cgaggcgtgc 2221 aagaaggtct tcctggactg ctgcaactac atcacagagc tgcggcggca gcacgcgcgg 2281 gccagccacc tgggcctggc caggagtaac ctggatgagg acatcattgc agaagagaac 2341 atcgtttccc gaagtgagtt cccagagagc tggctgtgga acgttgagga cttgaaagag 2401 ccaccgaaaa atggaatctc tacgaagctc atgaatatat ttttgaaaga ctccatcacc 2461 acgtgggaga ttctggctgt cagcatgtcg gacaagaaag ggatctgtgt ggcagacccc 2521 ttcgaggtca cagtaatgca ggacttcttc atcgacctgc ggctacccta ctctgttgtt 2581 cgaaacgagc aggtggaaat ccgagccgtt ctctacaatt accggcagaa ccaagagctc 2641 aaggtgaggg tggaactact ccacaatcca gccttctgca gcctggccac caccaagagg 2701 cgtcaccagc agaccgtaac catccccccc aagtcctcgt tgtccgttcc atatgtcatc 2761 gtgccgctaa agaccggcct gcaggaagtg gaagtcaagg ctgccgtcta ccatcatttc 2821 atcagtgacg gtgtcaggaa gtccctgaag gtcgtgccgg aaggaatcag aatgaacaaa 2881 actgtggctg ttcgcaccct ggatccagaa cgcctgggcc gtgaaggagt gcagaaagag 2941 gacatcccac ctgcagacct cagtgaccaa gtcccggaca ccgagtctga gaccagaatt 3001 ctcctgcaag ggaccccagt ggcccagatg acagaggatg ccgtcgacgc ggaacggctg 3061 aagcacctca ttgtgacccc ctcgggctgc ggggaacaga acatgatcgg catgacgccc 3121 acggtcatcg ctgtgcatta cctggatgaa acggagcagt gggagaagtt cggcctagag 3181 aagcggcagg gggccttgga gctcatcaag aaggggtaca cccagcagct ggccttcaga 3241 caacccagct ctgcctttgc ggccttcgtg aaacgggcac ccagcacctg gctgaccgcc 3301 tacgtggtca aggtcttctc tctggctgtc aacctcatcg ccatcgactc ccaagtcctc 3361 tgcggggctg ttaaatggct gatcctggag aagcagaagc ccgacggggt cttccaggag 3421 gatgcgcccg tgatacacca agaaatgatt ggtggattac ggaacaacaa cgagaaagac 3481 atggccctca cggcctttgt tctcatctcg ctgcaggagg ctaaagatat ttgcgaggag 3541 caggtcaaca gcctgccagg cagcatcact aaagcaggag acttccttga agccaactac 3601 atgaacctac agagatccta cactgtggcc attgctggct atgctctggc ccagatgggc 3661 aggctgaagg ggcctcttct taacaaattt ctgaccacag ccaaagataa gaaccgctgg 3721 gaggaccctg gtaagcagct ctacaacgtg gaggccacat cctatgccct cttggcccta 3781 ctgcagctaa aagactttga ctttgtgcct cccgtcgtgc gttggctcaa tgaacagaga 3841 tactacggtg gtggctatgg ctctacccag gccaccttca tggtgttcca agccttggct 3901 caataccaaa aggacgcccc tgaccaccag gaactgaacc ttgatgtgtc cctccaactg 3961 cccagccgca gctccaagat cacccaccgt atccactggg aatctgccag cctcctgcga 4021 tcagaagaga ccaaggaaaa tgagggtttc acagtcacag ctgaaggaaa aggccaaggc 4081 accttgtcgg tggtgacaat gtaccatgct aaggccaaag atcaactcac ctgtaataaa 4141 ttcgacctca aggtcaccat aaaaccagca ccggaaacag aaaagaggcc tcaggatgcc WO 00/09525 PCT7US99/17712 EPI-109 843 4201 aagaacacta tgatccttga gatctgtacc aggtaccggg gagaccagga tgccactatg 4261 tctatattgg acatatccat gatgactggc tttgctccag acacagatga cctgaagcag 4321 ctggccaatg gtgttgacag atacatctcc aagtatgagc tggacaaagc cttctccgat 4381 aggaacaccc ccatcatcta cctggacaag gtctcacact ctgaqgatga ctgtctagct 4441 ttcaaagttc accaatactt taatgtagag cttatccagc ctggagcagt caaggtctac 4501 gcctattaca acctggagga aagctgtacc cggttctacc atccggaaaa ggaggatgga 4561 aagctgaaca agctctgccg tgatgaactg tgccgctgtg ctgaggagaa ttgcttcata 4621 caaaagtcgg atgacaaggt caccctggaa gaacggctgg acaaggcctg tgagccagga 4681 gtggactatg tgtacaagac ccgactggtc aaggttcagc tgtccaatga ctttgacgag 4741 tacatcatgg ccattgagca gaccatcaag tcaggctcgg atgaggtgca ggttggacag 4801 cagcgcacgt tcatcagccc catcaagtgc agagaagccc tgaagctgga ggagaagaaa 4861 cactacctca tgtggggtct ctcctccgat ttctggggag agaagcccaa cctcagctac 4921 atcatcggga aggacacttg ggtggagcac tggcctgagg aggacgaatg ccaagacgaa 4981 gagaaccaga aacaatgcca ggacctcggc gccttcaccg agagcatggt tgtctttggg 5041 tgccccaact gaccacaccc ccattcc (2) INFORMATION FOR SEQ ID NO:2668: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2668 1 cgtgttgat atggagtagc ttcctttgtg cttaatctcc catctggagt gacggtgctg 61 gagtttaatg tcaaaactga tgctccagat cttccagaag aaaatcaggc cagggaaggt 121 taccgagcaa tagcatactc atctctcagc caaagttacc tttatattga ttggactgat 181 aaccataagg ctttgctagt gggagaacat ctgaatatta ttgttacccc caaaagccca 241 tatattgaca aaataactca ctataattac ttgattttat ccaagggcaa aattatccac 301 tttggcacga gggagaaatt ttcagatgca tcttatcaaa gtataaacat ccagtaaca 361 cagaacatgg ttccttcatc ccgacttctg gtctattata tcgtcacagg agaacagaca 421 gcagaattag tgtctgattc agtctggtta aatattgaag aaaaatgtgg caaccagctc 481 caggttcatc tgtctcctga tgcagatgca tattctccag gccaaactgt gtctcttaat 541 atggcaactg gaatggattc ctgggtggca ttagcagcag tggacagtgc tgtgtatgga 601 gtccaaagag gagccaaaaa gcccttggaa agagtatttc aattcttaga gaagagtgat 661 ctgggctgtg gggcaggtgg tggcctcaac aatgccaatg tgttccacct agctggactt 721 accttcctca ctaatgcaaa tgcagatgac tcccaagaaa atgatgaacc ttgtaaagaa 781 attctcaggc caagaagaac gctgcaaaag aagatagaag aaatagctgc taaatataaa 841 cattcagtag tgaagaaatg ttgttacgat ggagcctgcg ttaataatga tgaaacctgt 901 gagcagcgag ctgcacggat tagtttaggg ccaagatgca tcaaagcttt cactgaatgt 961 tgtgtcgtcg caagccagct ccgtgctaat atctctcata aagacatgca attgggaagg 1021 ctacacatga agaccctgtt accagtaagc aagccagaaa ttcggagtta ttttccagaa 1081 agctggttgt gggaagttca tcttgttccc agaagaaaac agttgcagt tgccctacct 1141 gattctctaa ccacctggga aattcaaggc attggcattt caaacactgg tatatgtgtt 1201 gctgatactg tcaaggcaaa ggtgttcaaa gatgtcttcc tggaaatgaa tataccatat 1261 tctqttgtac gaggagaaca gatccaattg aaaggaactg tttacaacca taggacttct 1321 gggatgcagt tctgtgttaa aatgtctgct gtggagggaa tctgcacttc ggaaagccca 1381 gtcattgatc atcagggcac aaagtcctcc aaatgtgtgc gccagaaagt agagggctcc 1441 tccagtcact tggtgacatt cactgtgctt cctctggaaa ttggccttca caacatcaat 1501 ttttcactgg agacttggtt tggaaaagaa atcttagtaa aaacattacg agtggtgcca 1561 gaaggtgtca aaagggaaag ctattctggt gttactttgg atcctagggg tatttatggt 1621 accattagca gacgaaagga gttcccatac aggataccct tagatttggt ccccaaaaca 1681 gaaatcaaaa ggattttgag tgtaaaagga ctgcttgtag gtgagatctt gtctgcagtt 1741 ctaagtcagg aaggcatcaa tatcctaacc cacctcccca aagggagtgc agaggcggag 1801 ctgatgagcg ttgtcccagt attctatgtt tttcactacc tggaaacagg aaatcattgg 1861 aacatttttc attctgaccc attaattgaa aagcagaaac tgaagaaaaa attaaaagaa 1921 gggatgttga gcattatgtc ctacagaaat gctgactact cttacagtgt gtggaagggt 1981 ggaagtgcta gcacttggtt aacagctttt gctttaagag tacttggaca agtaaataaa 2041 tacgtagagc agaaccaaaa ttcaatttgt aattctttat tgtggctagt tgagaattat 2101 caattagata atggatcttt caaggaaaat tcacagtatc aaccaataaa attacagggt 2161-accttgcctg ttgaagcccg agagaacagc ttatatctta cagcctttac tgtgattgga 2221 attagaaagg ctttcgatat atgccccctg gtgaaaatcg acacagctct aattaaagct 2281 gacaactttc tgcttgaaaa tacactgcca gcccagagca cctttacatt ggccatttct 2341 gcgtatgctc tttccctggg agataaaact cacccacagt ttcgttcaat tgtttcagct 2401 ttgaagagag aagctttggt taaaggtaat ccacccattt atcgtttttg gaaagacaat 2461 cttcagcata aagacagctc tgtacctaac actggtacgg cacgtatggt agaaacaact 2521 gcctatgctt tactcaccag tctgaacttg aaagatataa attatgttaa cccagtcatc 2581 aaatggctat cagaagagca gaggtatgga ggtggctttt attcaaccca ggacacaatc 2641 aatqccattg agggcctgac ggaatattca ctcctggtta aacaactccg cttgagtatg 2701 gacatcgatg tttcttacaa gcataaaggt gccttacata attataaaat gacagacaag WO 00/09525 PCT/US99/17712 EPI-109 844 2761 aatttccttg ggaggccagt agaggtgctt ctcaatgatg acctcattgt cagtacagga 2821 tttggcagtg gcttggczac agtacatgta acaactgtag ttcacaaaac cagtacctct 2881 gaggaagttt gcagctt~ta tttgaaaatc gatactcagg atattgaagc atcccactac 2941 agaggctacg gaaactctga ttacaaacgc atagtagcat gtgccagcta caagcccagc 3001 agggaagaat catcatczgg atcctctcat gcggtgatgg acatctcctt gcctactgga 3061 atcagtgcaa atgaagaaga cttaaaagcc cttgtggaag gggtggatca actattcact 3121 gattaccaaa tcaaagatgg acatgttatt ctgcaactga attcgattcc ctccagtgat 3181 ttcctttgtg tacgattccg gatatttgaa ctctttgaag ttgggtttct cagtcctgcc 3241 actttcacag tgtacgaata ccacagacca gataaacagt gtaccatgtt ttatagcact 3301 tccaatatca aaattcagaa agtctgtgaa ggagccgcgt gcaagtgtgt agaagctgat 3361 tgtgggcaaa tgcaggaaga attggatctg acaatctctg cagagacaag aaaacaaaca 3421 gcatgtaaac cagagattgc atatgcttat aaagttagca tcacatccat cactgtagaa 3481 aatgtttttg tcaagtacaa ggcaaccctt ctggatatct acaaaactgg ggaagctgtt 3541 gctgagaaag actctgaaat taccttcatt aaaaaggtaa cctgtactaa cgctgagctg 3601 gtaaaaggaa gacagtactt aattatgggt aaagaagccc tccagataaa atacaatttc 3661 agtttcaggt acatctaccc tttagattcc ttgacctgga ttgaatactg gcctagagac 3721 acaacatgtt catcgtgtca agcattttta gctaatttag atgaatttgc cgaagatatc 3781 tttttaaatg gatgctaaaa ttcctgaagt tcagctgcat acagtttgca cttatggact 3841 cctgttgttg aagttcgttt ttttgttttc ttcttttttt aaacattcat agctggtctt 3901 atttgtaaag ctcactttac ttagaattag tggcacttgc ttttattaga gaatgatttc 3961 aaatgctgta actttctgaa ataacatggc cttggagggc atgaagacag atactcctcc 4021 aaggttattg gacaccggaa acaataaatt ggaacacctc ctcaaaccta ccactcagga 4081 atgtttgctg gggccgaaag aacagtccat tgaaagggag tattacaaaa acatggcctt 4141 tgcttgaaag aaaataccaa ggaacaggaa actgatcatt aaagcctgag tttgctttc (2) INFORMATION FOR SEQ ID NO:2669: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2669 1 ctacctccaa ccatgggcct tttgggaata ctttgttttt taatcttcct ggggaaaacc 61 tggggacagg agcaaacata tgtcatttca gcaccaaaaa tattccgtgt tggagcatct 121 gaaaatattg tgattcaagt ttatggatac actgaagcat ttgatgcaac aatctctatt 181 aaaagttatc ctgataaaaa atttagttac tcctcaggcc atgttcattt atcctcagag 241 aataaattcc aaaactctgc aatcttaaca atacaaccaa aacaattgcc tggaggacaa 301 aacccagttt cttatgtgta tttggaagtt gtatcaaagc atttttcaaa atcaaaaaga 361 atgccaataa cctatgacaa tggatttctc ttcattcata cagacaaacc tgtttatact 421 ccagaccagt cagtaaaagt tagagtttat tcgttgaatg acgacttgaa gccagccaaa 481 agagaaactg tcttaacctt catagatcct gaaggatcag aagttgacat ggtagaagaa 541 attgatcata ttggaattat ctcttttcct gacttcaaga ttccgtctaa tcctagatat 601 ggtatgtgga cgatcaaggc taaatataaa gaggactttt caacaactgg aaccgcatat 661 tttgaagtta aagaatatgt cttgccacat ttttctgtct caatcgagcc agaatataat 721 ttcattggtt acaagaactt taagaatttt gaaattacta taaaagcaag atatttttat 781 aataaagtag tcactgaggc tgacgtttat atcacatttg gaataagaga agacttaaaa 841 gatgatcaaa aagaaatgat gcaaacagca atgcaaaaca caatgttgat aaatggaatt 901 gctcaagtca catttgattc tgaaacagca gtcaaagaac tgtcatacta cagtttagaa 961 gatttaaaca acaagtacct ttatattgct gtaacagtca tagagtctac aggtggattt 1021 tctgaagagg cagaaatacc tggcatcaaa tatgtcctct ctccctacaa actgaatttg 1081 gttgctactc ctcttttcct gaagcctggg attccatatc ccatcaaggt gcaggttaaa 1141 gattcgcttg accagttggt aggaggagtc ccagtaatac tgaatgcaca aacaattgat 1201 gtaaaccaag agacatctga cttggatcca agcaaaagtg taacacgtgt tgatgatgga 1261 gtagcttcct ttgtgcttaa tctcccatct ggagtgacgg tgctggagtt taatgtcaaa 1321 actgatgctc cagatcttcc agaagaaaat caggccaggg aaggttaccg agcaatagca 1381 tactcatctc tcagccaaag ttacctttat attgattgga ctgataacca taaggctttg 1441 ctagtgggag aacatctgaa tattattgtt acccccaaaa gcccatatat tgacaaaata 1501 actcactata attacttgat tttatccaag ggcaaaatta tccattttgg cacgagggag 1561 aaattttcag atgcatctta tcaaagtata aacattccag taacacagaa catggttcct 1621 tcatcccgac ttctggtcta ttatatcgtc acaggagaac agacagcaga attagtgtct 1681 gattcagtct ggttaaatat tgaagaaaaa tgtggcaacc agctccaggt tcatctgtct 1741 cctgatgcag atgcatattc tccaggccaa actgtgtctc ttaatatggc aactggaatg 1801 gattcctggg tggcattagc agcagtggac agtgctgtgt atggagtcca aagaggagcc 1861 aaaaagccct tggaaagagt atttcaattc ttagagaaga gtgatctggg ctgtggggca 1921 ggtggtggcc tcaacaatgc caatgtgttc cacctagctg gacttacctt cctcactaat 1981 gcaaatgcag atgactccca agaaaatgat gaaccttgta aagaaattct caggccaaga 2041 agaacgctgc aaaagaagat agaagaaata gctgctaaat ataaacattc agtagtgaag 2101 aaatgttgtt acgatggagc ctgcgttaat aatgatgaaa cctgtgagca gcgagctgca 2161 cggattagtt tagggccaag atgcatcaaa gctttcactg aatgttgtgt cgtcgcaagc WO 00/09525 PCT/US99/17712 EPI-109 845 2221 cagctccgtg ctaatatctc tcataaagac atgcaattgg gaaggczaca catgaagacc 2281 ctgttaccag taaqcaagcc agaaattcgg agttattttc cagaaagctg gttgtgggaa 2341 gttcatcttg ttcccagaag aaaacagttg cagtttgccc tacctgattc tctaaccacc 2401 tgggaaattc aaggcattgg catttcaaac actggtatat gtgttgctga tactgtcaag 2461 gcaaaggtgt tcaaagatgt cttcctggaa atgaatatac catattctgt tgtacgagga 2521 gaacagatcc aattgaaagg aactgtttac aactatagga cttctgggat gcagttctgt 2581 gttaaaatgt ctgctgtgga gggaatctgc acttcggaaa gcccagtcat tgatcatcag 2641 ggcacaaagt cctccaaatg tgtgcgccag aaagtagagg gctcctccag tcacttggtg 2701 acattcactg tgcttcctct ggaaattggc cttcacaaca tcaatttttc actggagact 2761 tggtttggaa aagaaatctt agtaaaaaca ttacgagtgg tgccagaagg tgtcaaaagg 2821 gaaagctatt ctggtgttac tttggatcct aggggtattt atggtaccat tagcagacga 2881 aaggagttcc catacaggat acccttagat ttggtcccca aaacagaaat caaaaggatt 2941 ttgagtgtaa aaggactgct tgtaggtgag atcttgtctg cagttctaag tcaggaaggc 3001 atcaatatcc taacccacct ccccaaaggg agtgcagagg cggagctgat gagcgttgtc 3061 ccagtattct atgtttttca ctacctggaa acaggaaatc attggaacat ttttcattct 3121 gacccattaa ttgaaaagca gaaactgaag aaaaaattaa aagaagggat gttgagcatt 3181 atgtcctaca gaaatgctga ctactcttac agtgtgtgga agggtggaag tgctagcact 3241 tggttaacag cttttgcttt aagagtactt ggacaagtaa ataaatacgt agagcagaac 3301 caaaattcaa tttgtaattc tttattgtgg ctagttgaga attatcaatt agataatgga 3361 tctttcaagg aaaattcaca gtatcaacca ataaaattac agggtacctt gcctgttgaa 3421 gcccgagaga acagcttata tcttacagcc tttactgtga ttggaattag aaaggctttc 3481 gatatatgcc ccctggtgaa aatcgacaca gctctaatta aagctgacaa ctttctgctt 3541 gaaaatacac tgccagccca gagcaccttt acattggcca tttctgcgta tgctctttcc 3601 ctgggagata aaactcaccc acagtttcgt tcaattgttt cagctttgaa gagagaagct 3661 ttggttaaag gtaatccacc catttatcgt ttttggaaag acaatcttca gcataaagac 3721 agctctgtac ctaacactgg tacggcacgt atggtagaaa caactgccta tgctttactc 3781 accagtctga acttgaaaga tataaattat gttaacccag tcatcaaatg gctatcagaa 3841 gagcagaggt atggaggtgg cttttattca acccaggaca ccatcaatgc cattgagggc 3901 ctgacggaat attcactcct ggttaaacaa ctccgcttga gtatggacat cgatgtttct 3961 tacaagcata aaggtgcctt acataattat aaaatgacag acaagaattt ccttgggagg 4021 ccagtagagg tgcttctcaa tgatgacctc attgtcagta caggatttgg cagtggcttg 4081 gctacagtac atgtaacaac tgtagttcac aaaaccagta cctctgagga agtttgcagc 4141 ttttatttga aaatcgatac tcaggatatt gaagcatccc actacagagg ctacggaaac 4201 tctgattaca aacgcatagt agcatgtgcc agctacaagc ccagcaggga agaatcatca 4261 tctggatcct ctcatgcggt gatggacatc tccttgccta ctggaatcag tgcaaatgaa 4321 gaagacttaa aagcccttgt ggaaggggtg gatcaactat tcactgatta ccaaatcaaa 4381 gatggacatg ttattctgca actgaattcg attccctcca gtgatttcct ttgtgtacga 4441 ttccggatat ttgaactctt tgaagttggg tttctcagtc ctgccacttt cacagtttac 4501 gaataccaca gaccagataa acagtgtacc atgttttata gcacttccaa tatcaaaatt 4561 cagaaagtct gtgaaggagc cgcgtgcaag tgtgtagaag ctgattgtgg gcaaatgcag 4621 gaagaattgg atctgacaat ctctgcagag acaagaaaac aaacagcatg taaaccagag 4681 attgcatatg cttataaagt tagcatcaca tccatcactg tagaaaatgt ttttgtcaag 4741 tacaaggcaa cccttctgga tatctacaaa actggggaag ctgttgotga gaaagactct 4801 gagattacct tcattaaaaa ggtaacctgt actaacgctg agctggtaaa aggaagacag 4861 tacttaatta tgggtaaaga agccctccag ataaaataca atttcagttt caggtacatc 4921 taccctttag attccttgac ctggattgaa tactggccta gagacacaac atgttcatcg 4981 tgtcaagcat ttttagctaa tttagatgaa tttgccgaag atatcztttt aaatggatgc 5041 taaaattcct gaagttcagc tgcatacagt ttgcacttat ggactcctgt tgttgaagtt 5101 cgtttttttg ttttcttctt tttttaaaca ttcatagctg gtcttatttg taaagctcac 5161 tttacttaga attagtggca cttgctttta ttagagaatg atttcaaatg ctgtaacttt 5221 ctgaaataac atggccttgg agggcatgaa gacagatact cctccaaggt tattggacac 5281 cggaaacaat aaattggaac acctcctcaa acctaccact caggaatgtt tgctggggcc 5341 gaaagaacag tccattgaaa gggagtatta caaaaacatg gcctttgctt gaaagaaaat 5401 accaaggaac aggaaactga tcattaaagc ctgagtttgc tttc (2) INFORMATION FOR SEQ ID NO:2670: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2670 1 ctacctccaa ccatgggcct tttgggaata ctttgttttt taatcttcct ggggaaaacc 61 tggggacagg agcaaacata tgtcatttca gcaccaaaaa tattccgtgt tggagcatct 121 gaaaatattg tgattcaagt ttatggatac actgaagcat ttgatgcaac aatctctatt 181 aaaagttatc ctgataaaaa atttagttac tcctcaggcc atgttcattt atcctcagag 241 aataaattcc aaaactctgc aatcttaaca atacaaccaa aacaattgcc tggaggacaa 301 aacccagttt cttatgtgta tttggaagtt gtatcaaagc atttttcaaa atcaaaaaga 361 atgccaataa cctatgacaa tggatttctc ttcattcata cagacaaacc tgtttatact WO 00/09525 PCT/US99/17712 EPI-109 846 421 ccagaccagt cagtaaaagt tagagtttat tcgttgaatg acgacttgaa gccagccaaa 481 agagaaactg tcttaacctt catagatcct gaaggatcag aagttgacat ggtagaagaa 541 attgatcata ttggaattat ctcttttcct gacttcaaga ttccgtctaa tcctagatat 601 ggtatgtgga cgatcaaggc taaatataaa gaggactttt caacaactgg aaccgcatat 661 tttgaagtta aagaatatgt cttgccacat ttttctgtct caatcgagcc agaatataat 721 ttcattggtt acaagaactt taagaatttt gaaattacta taaaagcaag atatttttat 781 aataaagtag tcactgaggc tgacgtttat atcacatttg gaataagaga agacttaaaa 841 gatgatcaaa aagaaatgat gcaaacagca atgcaaaaca caatgttgat aaatggaatt 901 gctcaagtca catttgattc tgaaacagca gtcaaagaac tgtcatacta cagtttagaa 961 gatttaaaca acaagtacct ttatattgct gtaacagtca tagagtctac aggtggattt 1021 tctgaagagg cagaaatacc tggcatcaaa tatgtcctct ctccctacaa actgaatttg 1081 gttgctactc ctcttttcct gaagcctggg attccatatc ccatcaaggt gcaggttaaa 1141 gattcgcttg accagttggt aggaggagtc ccagtaatac tgaatgcaca aacaattgat 1201 gtaaaccaag agacatctga cttggatcca agcaaaagtg taacacgtgt tgatgatgga 1261 gtagcttcct ttgtgcttaa tctcccatct ggagtgacgg tgctggagtt taatgtcaaa 1321 actgatgctc cagatcttcc agaagaaaat caggccaggg aaggttaccg agcaatagca 1381 tactcatctc tcagccaaag ttacctttat attgattgga ctgataacca taaggctttg 1441 ctagtgggag aacatctgaa tattattgtt acccccaaaa gcccatatat tgacaaaata 1501 actcactata attacttgat tttatccaag ggcaaaatta tccattttgg cacgagggag 1561 aaattttcag atgcatctta tcaaagtata aacattccag taacacagaa catggttcct 1621 tcatcccgac ttctggtcta ttatatcgtc acaggagaac agacagcaga attagtgtct 1681 gattcagtct ggttaaatat tgaagaaaaa tgtggcaacc agctccaggt tcatctgtct 1741 cctgatgcag atgcatattc tccaggccaa actgtgtctc ttaatatggc aactggaatg 1801 gattcctggg tggcattagc agcagtggac agtgctgtgt atggagtcca aagaggagcc 1861 aaaaagccct tggaaagagt atttcaattc ttagagaaga gtgatctggg ctgtggggca 1921 ggtggtggcc tcaacaatgc caatgtgttc cacctagctg gacttacctt cctcactaat 1981 gcaaatgcag atgactccca agaaaatgat gaaccttgta aagaaattct caggccaaga 2041 agaacgctgc aaaagaagat agaagaaata gctgctaaat ataaacattc agtagtgaag 2101 aaatgttgtt acgatggagc ctgcgttaat aatgatgaaa cctgtgagca gcgagctgca 2161 cggattagtt tagggccaag atgcatcaaa gctttcactg aatgttgtgt cgtcgcaagc 2221 cagctccgtg ctaatatctc tcataaagac atgcaattgg gaaggctaca catgaagacc 2281 ctgttaccag taagcaagcc agaaattcgg agttattttc cagaaagctg gttgtgggaa 2341 gttcatcttg ttcccagaag aaaacagttg cagtttgccc tacctgattc tctaaccacc 2401 tgggaaattc aaggcattgg catttcaaac actggtatat gtgttgctga tactgtcaag 2461 gcaaaggtgt tcaaagatgt cttcctggaa atgaatatac catattctgt tgtacgagga 2521 gaacagatcc aattgaaagg aactgtttac aactatagga cttctgggat gcagttctgt 2581 gttaaaatgt ctgctgtgga gggaatctgc acttcggaaa gcccagtcat tgatcatcag 2641 ggcacaaagt cctccaaatg tgtgcgccag aaagtagagg gctcctccag tcacttggtg 2701 acattcactg tgcttcctct ggaaattggc cttcacaaca tcaatttttc actggagact 2761 tggtttggaa aagaaatctt agtaaaaaca ttacgagtgg tgccagaagg tgtcaaaagg 2821 gaaagctatt ctggtgttac tttggatcct aggggtattt atggtaccat tagcagacga 2881 aaggagttcc catacaggat acccttagat ttggtcccca aaacagaaat caaaaggatt 2941 ttgagtgtaa aaggactgct tgtaggtgag atcttgtctg cagttctaag tcaggaaggc 3001 atcaatatcc taacccacct ccccaaaggg agtgcagagg cggagctgat gagcgttgtc 3061 ccagtattct atgtttttca ctacctggaa acaggaaatc attggaacat ttttcattct 3121 gacccattaa ttgaaaagca gaaactgaag aaaaaattaa aagaagggat gttgagcatt 3181 atgtcctaca gaaatgctga ctactcttac agtgtgtgga agggtggaag tgctagcact 3241 tggttaacag cttttgcttt aagagtactt ggacaagtaa ataaatacgt agagcagaac 3301 caaaattcaa tttgtaattc tttattgtgg ctagttgaga attatcaatt agataatgga 3361 tctttcaagg aaaattcaca gtatcaacca ataaaattac agggtacctt gcctgttgaa 3421 gcccgagaga acagcttata tcttacagcc tttactgtga ttggaattag aaaggctttc 3481 gatatatgcc ccctggtgaa aatcgacaca gctctaatta aagctgacaa ctttctgctt 3541 gaaaatacac tgccagccca gagcaccttt acattggcca tttctgcgta tgctctttcc 3601 ctgggagata aaactcaccc acagtttcgt tcaattgttt cagctttgaa gagagaagct 3661 ttggttaaag gtaatccacc catttatcgt ttttggaaag acaatcttca gcataaagac 3721 agctctgtac ctaacactgg tacggcacgt atggtagaaa caactgccta tgctttactc 3781 accagtctga acttgaaaga tataaattat gttaacccag tcatcaaatg gctatcagaa 3841 gagcagaggt atggaggtgg cttttattca acccaggaca ccatcaatgc cattgagggc 3901 ctgacggaat attcactcct ggttaaacaa ctccgcttga gtatggacat cgatgtttct 3961' tacaagcata aaggtgcctt acataattat aaaatgacag acaagaattt ccttgggagg 4021 ccagtagagg tgcttctcaa tgatgacctc attgtcagta caggatttgg cagtggcttg 4081 gctacagtac atgtaacaac tgtagttcac aaaaccagta cctctgagga agtttgcagc 4141 ttttatttga aaatcgatac tcaggatatt gaagcatccc actacagagg ctacggaaac 4201 tctgattaca aacgcatagt agcatgtgcc agctacaagc ccagcaggga agaatcatca 4261 tctggatcct ctcatgcggt gatggacatc tccttgccta ctggaatcag tgcaaatgaa 4321 gaagacttaa aagcccttgt ggaaggggtg gatcaactat tcactgatta ccaaatcaaa 4381 gatggacatg ttattctgca actgaattcg attccctcca gtgatttcct ttgtgtacga 4441 ttccggatat ttgaactctt tgaagttggg tttctcagtc ctgccacttt cacagtttac WO 00/09525 PCTIUS99/17712 EPI-109 847 4501 gaataccaca gaccagataa acagtgtacc atgttttata gcacttccaa tatcaaaatt 4561 cagaaagtct gtgaaggagc cgcgtgcaag tgtgtagaag ctgattgtgg gcaaatgcag 4621 gaagaattgg atctgacaat ctctgcagag acaagaaaac aaacagcatg taaaccagag 4681 attgcatatg cttataaagt tagcatcaca tccatcactg tagaaaatgt ttttgtcaag 4741 tacaaggcaa cccttctgga tatctacaaa actggggaag ctgttgctga gaaagactct 4801 gagattacct tcattaaaaa ggtaacctgt actaacgctg agctggtaaa aggaagacag 4861 tacttaatta tgggtaaaga agccctccag ataaaataca atttcagttt caggtacatc 4921 taccctttag attccttgac ctggattgaa tactggccta gagacacaac atgttcatcg 4981 tgtcaagcat ttttagctaa tttagatgaa tttgccgaag atatcttttt aaatggatgc 5041 taaaattcct gaagttcagc tgcatacagt ttgcacttat ggactcctgt tgttgaagtt 5101 cgtttttttg ttttcttctt tttttaaaca ttcatagctg gtcttatttg taaagctcac 5161 tttacttaga attagtggca cttgctttta ttagagaatg atttcaaatg ctgtaacttt 5221 ctgaaataac atggccttgg agggcatgaa gacagatact cctccaaggt tattggacac 5281 cggaaacaat aaattggaac acctcctcaa acctaccact caggaatgtt tgctggggcc 5341 gaaagaacag tccattgaaa gggagtatta caaaaacatg gcctttgctt gaaagaaaat 5401 accaaggaac aggaaactga tcattaaagc ctgagtttgc tttc (2) INFORMATION FOR SEQ ID NO:2671: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2671 1 cgtgttgatg atggagtagc ttcctttgtg cttaatctcc catctggagt gacggtgctg 61 gagtttaatg tcaaaactga tgctccagat cttccagaag aaaatcaggc cagggaaggt 121 taccgagcaa tagcatactc atctctcagc caaagttacc tttatattga ttggactgat 181 aaccataagg ctttgctagt gggagaacat ctgaatatta ttgttacccc caaaagccca 241 tatattgaca aaataactca ctataattac ttgattttat ccaagggcaa aattatccac 301 tttggcacga gggagaaatt ttcagatgca tcttatcaaa gtataaacat tccagtaaca 361 cagaacatgg ttccttcatc ccgacttctg gtctattata tcgtcacagg agaacagaca 421 gcagaattag tgtctgattc agtctggtta aatattgaag aaaaatgtgg caaccagctc 481 caggttcatc tgtctcctga tgcagatgca tattctccag gccaaactgt gtctcttaat 541 atggcaactg gaatggattc ctgggtggca ttagcagcag tggacagtgc tgtgtatgga 601 gtccaaagag gagccaaaaa gcccttggaa agagtatttc aattcttaga gaagagtgat 661 ctgggctgtg gggcaggtgg tggcctcaac aatgccaatg tgttccacct agctggactt 721 accttcctca ctaatgcaaa tgcagatgac tcccaagaaa atgatgaacc ttgtaaagaa 781 attctcaggc caagaagaac gctgcaaaag aagatagaag aaatagctgc taaatataaa 841 cattcagtag tgaagaaatg ttgttacgat ggagcctgcg ttaataatga tgaaacctgt 901 gagcagcgag ctgcacggat tagtttaggg ccaagatgca tcaaagcttt cactgaatgt 961 tgtgtcgtcg caagccagct ccgtgctaat atctctcata aagacatgca attgggaagg 1021 ctacacatga agaccctgtt accagtaagc aagccagaaa ttcggagtta ttttccagaa 1081 agctggttgt gggaagttca tcttgttccc agaagaaaac agttgcagtt tgccctacct 1141 gattctctaa ccacctggga aattcaaggc attggcattt caaacactgg tatatgtgtt 1201 gctgatactg tcaaggcaaa ggtgttcaaa gatgtcttcc tggaaatgaa tataccatat 1261 tctgttgtac gaggagaaca gatccaattg aaaggaactg tttacaacta taggacttct 1321 gggatgcagt tctgtgtcaa aatgtctgct gtggagggaa tctgcacttc ggaaagccca 1381 gtcattgatc atcagggcac aaagtcctcc aaatgtgtgc gccagaaagt agagggctcc 1441 tccagtcact tggtgacatt cactgtgctt cctctggaaa ttggcctca caacatcaat 1501 ttttcactgg agacttggtt tggaaaagaa atcttagtaa aaacattacg agtggtgcca 1561 gaaggtgtca aaagggaaag ctattctggt gttactttgg atcctagggg tatttatggt 1621 accattagca gacgaaagga gttcccatac aggataccct tagatttggt ccccaaaaca 1681 gaaatcaaaa ggattttgag tgtaaaagga ctgcttgtag gtgagatctt gtctgcagtt 1741 ctaagtcagg aaggcatcaa tatcctaacc cacctcccca aagggagtgc agaggcggag 1801 ctgatgagcg ttgtcccagt attctatgtt tttcactacc tggaaacagg aaatcattgg 1861 aacatttttc attctgaccc attaattgaa aagcagaaac tgaagaaaaa attaaaagaa 1921 gggatgttga gcattatgtc ctacagaaat gctgactact cttacagtgt gtggaagggt 1981 ggaagtgcta gcacttggtt aacagctttt gctttaagag tacttggaca agtaaataaa 2041 tacgtagagc agaaccaaaa ttcaatttgt aattctttat tgtggctagt tgagaattat 2101. caattagata atggatcttt caaggaaaat tcacaggatc aaccaataaa attacagggt 2161 accttgcctg ttgaagcccg agagaacagc ttatatctta cagcctttac tgtgattgga 2221 attagaaagg ctttcgatat atgccccctg gtgaaaatcg acacagctct aattaaagct 2281 gacaactttc ggcttgaaaa tacactgcca gcccagagca cctttacatt ggccatttct 2341 gcgtatgctc tttccctggg agataaaact cacecacagt ttcgttcaat tgtttcagct 2401 ttgaagagag aagctttggt taaaggtaat ccacccattt atcgtttttg gaaagacaat 2461 cttcagcata aagacagctc tgtacctaac actggtacgg cacgtatggt agaaacaact 2521 gcctatgctt tacccaccag tctgaacttg aaagatataa attatgttaa cccagtcatc 2581 aaatggctat cagaagagca gaggtatgga ggtggctttt attcaaccca ggacacaatc 2641 aatgccattg agggcctgac ggaatattca ctcctggtta aacaactccg cttgagtatg WO 00/09525 PCT/US99/17712 EPI-109 848 2701 gacatcgatg tttcttacaa gcataaaggt gccttacata attataaaat gacagacaag 2761 aatttccttg ggaggccagt agaggtgctt ctcaatgatg acctcattgt cagtacagga 2821 tttggcagtg gcttggctac agtacatgta acaactgtag ttcacaaaac cagtacctct 2881 gaggaagttt gcagctttza tttgaaaatc gatactcagg atattgaagc atcccactac 2941 agaggctacg gaaactctga ttacaaacgc atagtagcat gtgccagcta caagcccagc 3001 agggaagaat catcatctgg atcctctcat gcggtgatgg acatctcctt gcctactgga 3061 atcagtgcaa atgaagaaga cttaaaagcc cttgtggaag gggtggatca actattcact 3121 gattaccaaa tcaaagatgg acatgttatt ctgcaactga attcgattcc ctccagtgat 3181 ttcctttgtg tacgattccg gatatttgaa ctctttgaag ttgggtttct cagtcctgcc 3241 actttcacag tgtacgaata ccacagacca gataaacagt gtaccatgtt ttatagcact 3301 tccaatatca aaattcagaa agtctgtgaa ggagccgcgt gcaagtgtgt agaagctgat 3361 tgtgggcaaa tgcaggaaga attggatctg acaatctctg cagagacaag aaaacaaaca 3421 gcatgtaaac cagagattgc atatgcttat aaagttagca tcacatccat cactqtagaa 3481 aatgtttttg tcaagtacaa ggcaaccctt ctggatatct acaaaactgg ggaagctgtt 3541 gctgagaaag actctgagat taccttcatt aaaaaggtaa cctgtactaa cgctgagctg 3601 gtaaaaggaa gacagtactt aattatgggt aaagaagccc tccagataaa atacaatttc 3661 agtttcaggt acatctaccc tttagattcc ttgacctgga ttgaatactg gcctagagac 3721 acaacatgtt catcgtgtca agcattttta gctaatttag atgaatttgc cgaagatatc 3781 tttttaaatg gatgctaaaa ttcctgaagt tcagctgcat acagtttgca cttatggact 3841 cctgttgttg aagttcgttt ttttgttttc ttcttttttt aaacattcat agctggtctt 3901 atttgtaaag ctcactttac ttagaattag tggcacttgc ttttattaga gaatgatttc 3961 aaatgctgta actttctgaa ataacatggc cttggagggc atgaagacag atactcctcc 4021 aaggttattg gacaccggaa acaataaatt ggaacacctc ctcaaaccta ccactcagga 4081 atgtttgctg gggccgaaag aacagtccat tgaaagggag tattacaaaa acatggcctt 4141 tgcttgaaag aaaataccaa ggaacaggaa actgatcatt aaagcctgag tttgctttc 1 ctacctccaa ccatgggcct tttgggaata ctttgttttt taatcttcct gggaaaacc 61 tggggacagg agcaaacata tgtcatttca gcaccaaaaa tattccgtgt tggagcatct 121 gaaaatattg tgattcaagt ttatggatac actgaagcat ttgatgcaac aatctctatt 181 aaaagttatc ctgataaaaa atttagttac tcctcaggcc atgttcattt atcctcagag 241 aataaattcc aaaactctc aatcttaaca atacaaccaa aacaattgcc tggaggacaa 301 aacccagttt cttatgtgta tttggaagtt gtatcaaagc atttttcaaa atcaaaaaga 361 atgccaataa cctatgacaa tggatttctc ttcattcata cagacaaacc tgtttatact 421 ccagaccagt cagtaaaagt tagagtttat tcgttgaatg acgacttgaa gccagccaaa 481 agagaaactg tcttaacctt catagatcct gaaggatcag aagttgacat ggtagaagaa 541 attgatcata ttggaattat ctcttttcct gacttcaaga ttccgtctaa tcctagatat 601 ggtatgtgga cgatcaaggc taaatataaa gaggactttt caacaactgg aaccgcatat 661 tttgaagtta aagaatatgt cttgccacat ttttctgtct caatcgagcc agaatataat 721 ttcattggtt acaagaactt taagaatttt gaaattacta taaaagcaag atatttttat 781 aataaagtag tcactgaggc tgacgtttat atcacatttg gaataagaga agacttaaaa 841 gatgatcaaa aagaaatgat gcaaacagca atgcaaaaca caatgttgat aaatggaatt 901 gctcaattca catttgattc tgaaacagca gtcaaagaac tgtcatacta cagtttagaa 961 gatttaaaca acaagtacct ttatattgct gtaacagtca tagagtctac aggtggattt 1021 tctgaagagg cagaaatacc tggcatcaaa tatgtcctct ctccctacaa actgaatttg 1081 gttgctactc ctcttttcct gaagcctggg attccatatc ccatcaaggt gcaggttaaa 1141 gattcgcttg accagttggt aggaggagtc ccagtaatac tgaatgcaca aacaattgat 1201 gtaaaccaag agacatctga cttggatcca agcaaaagtg taacacgtgt tgatgatgga 1261 gtagcttcct ttgtgcttaa tctcccatct ggagtgacgg tgctggagtt taatgtcaaa 1321 actgatgctc cagatctcc agaagaaaat caggccaggg aaggttaccg agcaatagca 1381 tactcatctc tcagccaaag ttacctttat attgattgga ctgataacca taaggctttg 1441 ctagtgggag aacatctgaa tattattgtt acccccaaaa gcccatatat tgacaaaata 1501 actcactata attacttgat tttatccaag ggcaaaatta tccattttgg cacgagggag 1561 aaattttcag atgcatctta tcaaagtata aacattccag taacacagaa catggttcct 1621 tcatcccgac ttctggtcta ttatatcgtc acaggagaac agacagcaga attagtgtct 1681 gattcagtct ggttaaatat tgaagaaaaa tgtggcaacc agctccaggt tcatctgtct 1741 cctgatgcag atgcatattc tccaggccaa actgtgtctc ttaatatggc aactggaatg 1801 gattcctggg tggcattagc agcagtggac agtgctgtgt atggagtcca aagaggagcc 1861 aaaaagccct tggaaagagt atttcaattc ttagagaaga gtgatctggg ctgtggqgca 1921 ggtggtggcc tcaacaatgc caatgtgttc cacctagctg gacttacctt cctcactaat 1981 gcaaatgcag atgactccca agaaaatgat gaaccttgta aagaaattct caggccaaga 2041 agaacgctgc aaaagaagat agaagaaata gctgctaaat ataaacattc agtagtgaag 2101 aaatgttgtt acgatggagc ctgcgttaat aatgatgaaa cctgtgagca gcgagctgca 2161 cggattagtt tagggccaag atgcattaaa gctttcactg aatgttgtgt cgtcgcaagc 2221 cagctccgtg ctaatatctc tcataaagac atgcaattgg gaaggctaca catgaagacc 2281 ctgttaccag taagcaagcc agaaattcgg agttattttc cagaaagctg gttgtgggaa 2341 gttcatcttg ttcccagaag aaaacagttg cagtttgccc tacctgattc tctaaccacc 2401 tgggaaattc aaggcattgg catttcaaac actggtatat gtgttgctga tactgtcaag 2461 gcaaaggtgt tcaaagargt cttcctggaa atgaatatac catattctgt tgtacgagga 2521 gaacagatcc aattgaaagg aactgtttac aactatagga cttctgggat gcagttctgt WO 00/09525 PCT/US99/17712 EPI-109 849 2581 gttaaaatgt ctgctgtgga gggaatctgc acttcggaaa gcccaatcat tgatcatcag 2641 ggcacaaagt cctccaaatg tgtgcgccag aaagtagagg gctccrccag tcacttggtg 2701 acattcactg tgcttcctct ggaaattggc cttcacaaca tcaatztttc actggagact 2761 tggtttggaa aagaaatctt agtaaaaaca ttacgagtgg tgccagaagg tgtcaaaagg 2821 gaaagctatt ctggtgttac tttggatcct aggggtattt atggtaccat tagcagacga 2881 aaggagttcc catacaggat acccttagat ttggtcccca aaacagaaat caaaaggatt 2941 ttgagtgtaa aaggactact tgtaggtgag atcttgtctg cagttczaag tcaggaaggc 3001 atcaatatcc taacccacct ccccaaaggg agtgcagagg cggagczgat gagcgttgtc 3061 ccagtattct atgtttttca ctacctggaa acaggaaatc attggaacat ttttcattct 3121 gacccattaa ttgaaaagca gaaactgaag aaaaaattaa aagaagggat gttgagcatt 3181 atgtcctaca gaaatgctga ctactcttac agtgtgtgga agggtggaag tgctagcact 3241 tggttaacag cttttgcttt aagagtactt ggacaagtaa ataaatacgt agagcagaac 3301 caaaattcaa tttgtaattc tttattgtgg ctagttgaga attatcaatt agataatgga 3361 tctttcaagg aaaattcaca gtatcaacca ataaaattac agggtacctt gcctgttgaa 3421 gcccgagaga acagcttata tcttacagcc tttactgtga ttggaattag aaaggctttc 3481 gatatatgcc ccctggtgaa aatcgacaca gctctaatta aagctgacaa ctttctgctt 3541 gaaaatacac tgccagccca gagcaccttt acattggcca tttctgcgta tgctctttcc 3601 ctgggagata aaactcaccc acagtttcgt tcaattgttt cagctttgaa gagagaagct 3661 ttggttaaag gtaatccacc catttatcgt ttttggaaag acaatcttca gcataaagac 3721 agctctgtac ctaacactgg tacggcacgt atggtagaaa caactgccta tgctttactc 3781 accagtctga acttgaaaga tataaattat gttaacccag tcatcaaatg gctatcagaa 3841 gagcagaggt atggaggtgg cttttattca acccaggaca ccatcaatgc cattgagggc 3901 ctgacggaat attcactcct ggttaaacaa ctccgcttga gtatggacat cgatgtttct 3961 tacaagcata aaggtgcctt acataattat aaaatgacag acaagaattt ccttgggagg 4021 ccagtagagg tgcttctcaa tgatgacctc attgtcagta caggatttgg cagtggcttg 4081 gctacagtac atgtaacaac tgtagttcac aaaaccagta cctctgagga agtttgcagc 4141 ttttatttga aaatcgatac tcaggatatt gaagcatccc actacagagg ctacggaaac 4201 tctgattaca aacgcatagt agcatgtgcc agctacaagc ccagcaggga agaatcatca 4261 tctggatcct ctcatgcggt gatggacatc tccttgccta ctggaatcag tgcaaatgaa 4321 gaagacttaa aagcccttgt ggaaggggtg gatcaactat tcactgatta ccaaatcaaa 4381 gatggacatg ttattctgca actgaattcg attccctcca gtgatttcct ttgtgtacga 4441 ttccggatat ttgaactctt tgaagttggg tttctcagtc ctgccacttt cacagtttac 4501 gaataccaca gaccagataa acagtgtacc atgttttata gcacttccaa tatcaaaatt 4561 cagaaagtct gtgaaggagc cgcgtgcaag tgtgtagaag ctgattgtgg gcaaatgcag 4621 gaagaattgg atctgacaat ctctgcagag acaagaaaac aaacagcatg taaaccagag 4681 attgcatatg cttataaagt tagcatcaca tccatcactg tagaaaatgt ttttgtcaag 4741 tacaaggcaa cccttctgga tatctacaaa actggggaag ctgttgctga gaaagactct 4801 gagattacct tcattaaaaa ggtaacctgt actaacgctg agctggtaaa aggaagacag 4861 tacttaatta tgggtaaaga agccctccag ataaaataca atttcagttt caggtacatc 4921 taccctttag attccttgac ctggattgaa tactggccta gagacacaac atgttcatcg 4981 tgtcaagcat ttttagctaa tttagatgaa tttgccgaag atatcttttt aaatggatgc 5041 taaaattcct gaagttcagc tgcatacagt ttgcacttat ggactcctgt tgttgaagtt 5101 cgtttttttg ttttcttctt tttttaaaca ttcatagctg gtcttatttg taaagctcac 5161 tttacttaga attagtggca cttgctttta ttagagaatg atttcaaatg ctgtaacttt 5221 ctgaaataac atggccttgg agggcatgaa gacagatact cctccaaggt tattggacac 5281 cggaaacaat aaattggaac acctcctcaa acctaccact caggaatgtt tgctggggcc 5341 gaaagaacag tccattgaaa gggagtatta caaaaacatg gcctttgctt gaaagaaaat 5401 accaaggaac aggaaactga tcattaaagc ctgagtttgc tttc 1 ctacctccaa ccatgggcct tttgggaata ctttgttttt taatcttcct ggggaaaacc 61 tggggacagg agcaaacata tgtcatttca gcaccaaaaa tattccgtgt tggagcatct 121 gaaaatattg tgattcaagt ttatggatac actgaagcat ttgatgcaac aatctctatt 181 aaaagttatc ctgataaaaa atttagttac tcctcaggcc atgttcattt atcctcagag 241 aataaattcc aaaactctgc aatcttaaca atacaaccaa aacaattgcc tggaggacaa 301 aacccagttt cttatgtgta tttggaagtt gtatcaaagc atttttcaaa atcaaaaaga 361 atgccaataa cctatgacaa tggatttctc ttcattcata cagacaaacc tgtttatact 421 ccagaccagt cagtaaaagt tagagtttat tcgttgaatg acgacttgaa gccagccaaa 481 agagaaactg tcttaacctt catagatcct gaaggatcag aagttgacat ggtagaagaa 541 attgatcata ttggaattat ctcttttcct gacttcaaga ttccgtctaa tcctagatat 601 ggtatgtgga cgatcaaggc taaatataaa gaggactttt caacaactgg aaccgcatat 66 1 tttgaagtta aagaatatgt cttgccacat ttttctgtct caatcgagcc agaatataat 721 ttcattggtt acaagaactt taagaatttt gaaattacta taaaagcaag atatttttat 781 aataaagtag tcactgaggc tgacgtttat atcacatttg gaataagaga agacttaaaa 841 gatgatcaaa aagaaatgat gcaaacagca atgcaaaaca caatgttgat aaatggaatt 901 gctcaagtca catttgattc tgaaacagca gtcaaagaac tgtcatacta cagtttagaa 961 gatttaaaca acaagtacct ttatattgct gtaacagtca tagagtctac aggtggattt 1021 tctgaagagg cagaaatacc tggcatcaaa tatgtcctct ctccctacaa actgaatttg 1081 gttgctactc ctcttttcct gaagcctggg attccatatc ccatcaaggt gcaggttaaa 1141 gattcgcttg accagttggt aggaggagtc ccagtaatac tgaatgcaca aacaattgat WO 00/09525 PCT/US99/17712 EPI-109 850 1201 gtaaaccaaa agacatctga cttggatcca agcaaaagtg taacacgtgt tgatgatgga 1261 gtagcttcct ttgtgcttaa tctcccatct ggagtgacgg tgctggagtt taatgtcaaa 1321 actgatgctc cagatcttcc agaagaaaat caggccaggg aaggttaccg agcaatagca 1381 tactcatctc tcagccaaag ttacctttat attgattgga ctgataacca taaggctttg 1441 ctagtgggag aacatctgaa tattattgtt acccccaaaa gcccatatat tgacaaaata 1501 actcactata attacttgat tttatccaag ggcaaaatta tccattttgg cacgagggag 1561 aaattttcag atgcatctta tcaaagtata aacattccag taacacagaa catggttcct 1621 tcatcccgac ttctggtcta ttatatcgtc acaggagaac agacagcaga attagtgtct 1681 gattcagtct ggttaaatat tgaagaaaaa tgtggcaacc agctccaggt tcatctgtct 1741 cctgatgcag atgcatattc tccaggccaa actgtgtctc ttaatatggc aactggaatg 1801 gattcctggg tggcattagc agcagtggac agtgctgtgt atggagtcca aagaggagcc 1861 aaaaagccct tggaaagagt atttcaattc ttagagaaga gtgatctggg ctgtggggca 1921 ggtggtggcc tcaacaatgc caatgtgttc cacctagctg gacttacctt cctcactaat 1981 gcaaatgcag atgactccca agaaaatgat gaaccttgta aagaaattct caggccaaga 2041 agaacgctgc aaaagaagat agaagaaata gctgctaaat ataaacattc agtagtgaag 2101 aaatgttgtt acgatggagc ctgcgttaat aatgatgaaa cctgtgagca gcgagctgca 2161 cggattagtt tagggccaag atgcatcaaa gctttcactg aatgttgtgt cgtcgcaagc 2221 cagctccgtg ctaatatctc tcataaagac atgcaattgg gaaggctaca catgaagacc 2281 ctgttaccag taagcaagcc agaaattcgg agttattttc cagaaagctg gttgtgggaa 2341 gttcatcttg ttcccagaag aaaacagttg cagtttgccc tacctgattc tctaaccacc 2401 tgggaaattc aaggcattgg catttcaaac actggtatat gtgttgctga tactgtcaag 2461 gcaaaggtgt tcaaagatgt cttcctggaa atgaatatac catattctgt tgtacgagga 2521 gaacagatcc aattgaaagg aactgtttac aactatagga cttctgggat gcagttctgt 2581 gttaaaatgz ctgctgtgga gggaatctgc acttcggaaa gcccagtcat tgatcatcag 2641 ggcacaaagt cctccaaatg tgtgcgccag aaagtagagg gctcctccag tcacttggtg 2701 acattcactg tgcttcctct ggaaattggc cttcacaaca tcaatttttc actggagact 2761 tggtttggaa aagaaatctt agtaaaaaca ttacgagtgg tgccagaagg tgtcaaaagg 2821 gaaagctatt ctggtgttac tttggatcct aggggtattt atggtaccat tagcagacga 2881 aaggagttcc catacaggat acccttagat ttggtcccca aaacagaaat caaaaggatt 2941 ttgagtgtaa aaggactgct tgtaggtgag atcttgtctg cagttctaag tcaggaaggc 3001 atcaatatcc taacccacct ccccaaaggg agtgcagagg cggagctgat gagcgttgtc 3061 ccagtattct atgtttttca ctacctggaa acaggaaatc attggaacat ttttcattct 3121 gacccattaa ttgaaaagca gaaactgaag aaaaaattaa aagaagggat gttgagcatt 3181 atgtcctaca gaaatgctga ctactcttac agtgtgtgga agggtggaag tgctagcact 3241 tggttaacag cttttgcttt aagagtactt ggacaagtaa ataaatacgt agagcagaac 3301 caaaattcaa tttgtaattc tttattgtgg ctagttgaga attatcaatt agataatgga 3361 tctttcaagg aaaattcaca gtatcaacca ataaaattac agggtacctt gcctgttgaa 3421 gcccgagaga acagcttata tcttacagcc tttactgtga ttggaattag aaaggctttc 3481 gatatatgcc ccctggtgaa aatcgacaca gctctaatta aagctgacaa ctttctgctt 3541 gaaaatacac tgccagccca gagcaccttt acattggcca tttctgcgta tgctctttcc 3601 ctgggagata aaactcaccc acagtttcgt tcaattgttt cagctttgaa gagagaagct 3661 ttggttaaag gtaatccacc catttatcgt ttttggaaag acaatcttca gcataaagac 3721 agctctgtac craacactgg tacggcacgt atggtagaaa caactgccta tgctttactc 3781 accagtctga acttgaaaga tataaattat gttaacccag tcatcaaatg gctatcagaa 3841 gagcagaggt atggaggtgg cttttattca acccaggaca ccatcaatgc cattgagggc 3901 ctgacggaat attcactcct ggttaaacaa ctccgcttga gtatggacat cgatgtttct 3961 tacaagcata aaggtgcctt acataattat aaaatgacag acaagaattt ccttgggagg 4021 ccagtagagg tgcttctcaa tgatgacctc attgtcagta caggatttgg cagtggcttg 4081 gctacagtac atgtaacaac tgtagttcac aaaaccagta cctctgagga agtttgcagc 4141 ttttatttga aaatcgatac tcaggatatt gaagcatccc actacagagg ctacggaaac 4201 tctgattaca aacgcatagt agcatgtgcc agctacaagc ccagcaggga agaatcatca 4261 tctggatcct ctcatgcggt gatggacatc tccttgccta ctggaatcag tgcaaatgaa 4321 gaagacttaa aagcccttgt ggaaggggtg gatcaactat tcactgatta ccaaatcaaa 4381 gatggacatg ttattctgca actgaattcg attccctcca gtgatttcct ttgtgtacga 4441 ttccggatat ttgaactctt tgaagttggg tttctcagtc ctgccacttt cacagtttac 4501 gaataccaca gaccagataa acagtgtacc atgttttata gcacttccaa tatcaaaatt 4561 cagaaagtct gtgaaggagc cgcgtgcaag tgtgtagaag ctgattgtgg gcaaatgcag 4621 gaagaattgg atctgacaat ctctgcagag acaagaaaac aaacagcatg taaaccagag 4681 attgcatatg cttataaagt tagcatcaca tccatcactg tagaaaatgt ttttgtcaag 474 1 tacaaggcaa cccttctgga tatctacaaa actggggaag ctgttgctga gaaagactct 4801 gagattacct tcattaaaaa ggtaacctgt actaacgctg agctggtaaa aggaagacag 4861 tacttaatta tgggtaaaga agccctccag ataaaataca atttcagttt caggtacatc 4921 taccctttag attccttgac ctggattgaa tactggccta gagacacaac atgttcatcg 4981 tgtcaagcat ttttagctaa tttagatgaa tttgccgaag atatcttttt aaatggatgc 5041 taaaattcct gaagttcagc tgcatacagt ttgcacttat ggactcctgt tgttgaagtt 5101 cgtttttttg ttttcttctt tttttaaaca ttcatagctg gtcttatttg taaagctcac 5161 tttacttaga attagtggca cttgctttta ttagagaatg atttcaaatg ctgtaacttt 5221 ctgaaataac atggccttgg agggcatgaa gacagatact cctccaaggt tattggacac WO 00/09525 PCT/US99/17712 EPI-109 851 5281 cggaaacaat aaattggaac acctcctcaa acctaccact caggaatgtt tgctggggcc 5341 gaaagaacag tccattgaaa gggagtatta caaaaacatg gcctttgctt gaaagaaaat 5401 accaaggaac aggaaacrga tcattaaagc ctgagtttgc tttc (2) INFORMATION FOR SEQ ID NO:2672: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: base Dairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2672 1 aagcttcagt atgcaaattt tcaatgacat gtgcctgtgg attctgaaaa ttcacagatc 61 tgtctatcct tagctgagac tgaaggcatc tacttcccaa tgaccaaatc ctggtgctgt 121 ggcgacactg agcaggaact ccattagaat atcaatatca ctctgcagac attccatgat 181 gtaagctatg ttttctcttg ttgcaattac acttaattta ccaccagctg cttcaatgtc 241 atgggctatc ttgaaaaatg aagctccttt cgtagtcaaa ctggatgcaa gacacagcaa 301 atgagaagtt actaaattgt tggagtcctc atagctactg cctgctttaa tgaacaaacc 361 aattcttgat gcagggcata gttttccaaa ggagaaatca taaaaccatt tggaaatttg 421 atgatctcaa ggtcctgatg atgtggagcc actcctatgg gggtagctgt ggctttaact 481 ttgggggcaa ctttgaggga ataaagtctc aaaaagaggg aataaagtct caagattgtt 541 cgtgacccat agtaacttct ggcttaaagg accattcggc aagtttttaa atgtattttc 601 tataatttcc atgtagttct ttatattttc tatttcttat ttaaaacctc tattttagct 661 cgtttccttt gacactgctc tggcagggaa aggggtggca ctgcctcatt actgccaggt 721 aggggtagaa gtccattatc cacttggtct ccattgatac ccaaagtggg gagaggctcc 781 tgttactgct ggtgagggtg ggagtccccc cactaagttt ctgctaatac tgtcctggtg 841 gcttgctact attcccarga agcctccact gatactacat tacttttggg tggtggcaaa 901 tgtcctgcct ctccactagc cctcctgctc taaaacaacc cgagtaggga gtgggaagga 961 agctttgtta ctggtaggtg ggagctgaag tccagacttg ccacattgtc ccactgatgc 1021 tacagggagg aggaagcggg ccacattact gcctgatagg gatgaaagcc ccagctccct 1081 acctggcctt cgctgatacc agcctgctac aggagtgaag agagatttga aggcctcaat 1141 atagcctgtc gagggtggaa gtcttgctcc caatgggcct ttagcagcat gggtgggtgt 1201 ggggccatag ctgtctctgt actgcttggc tagagtggag tatttgaggt ccaaaagttt 1261 tctgtctttc tagccctttg gttagaaaga gcagactttt gttggaagta tttttttgtg 1321 tttacctgtt gtatttccag gttcctagct tctccagcac agtctgggat gtgtgagaca 1381 cagagaaaat ccagtgatgt tactaccgta tggtttcttg ggtcccaacg tctctagcta 1441 atctgctcca ccttttggag ttttcttatt tgttttagat cagggattta gtcatattta 1501 ataggagaaa tatggaaaaa tacttctact ctatcttcct ggaagttcct gtttattttt 1561 tatgtccttt tcctctggct agaccgtaag agacttacga aacaaacact tacacattct 1621 actaaactca atgtccaaag tttgtgaact tcttgaatat tgcttgttca tttccacccc 1681 cagtcactga ctgaatctcc ctgctgtctg tctacaatgc caatgagctt ctggttaact 1741 tcttctcatg catgcttagg caacaacttc ccagttttac tacacttgcc catccctagt 1801 tttgttgttg cttaatccct tggcctagtg ccaccatact cctccagcag agcaaccaat 1861 tcttacatta taggacagca catatccact aaaaacagtt catgccacac caaccacatt 1921 tccctttgtc aacaaaatta cttgatagat aattccagga atgcctgatg aagctgattg 1981 acaacaagat atttggcaga ctctctgctg cctatacata ccttagcatg tggaactcaa 2041 gtaatgagag gtccatttaa ttggattgaa ttgggctgga taggattgga ttgaatcctg 2101 tgggatggct aggctaaatt agaaatgaag actagtttaa cagcagtatc caaggatagt 2161 tgactaatga gttaatttta ctctcaaaga cagtctttag tagtaagctg taatgcatta 2221 tatcaaacta ttttccagtc aatgatttat aagttacttg aataaggatg ctaaagatgt 2281 gccttattga aatggcaatt agcacaaagt tgggaatgaa atctaattag ttaaataaca 2341 gaatcacata aaaaaggact tgaataaatg tagcatccta ccatgttcct ggatagaaag 2401 actgctatcg taaagatatt cattctcctc aggttaaatt ataaactcaa tgcaattcaa 2461 caggatttta aaaaactaga caaagtgatt ccaagtttac gtggaaaata aaatgtgagg 2521 gaccaaacaa tatttgaaaa agaaagagaa taaaatctca tccttccaga taccacaatg 2581 tattataaag caatagtaat taacatgagg gcagaaatga gcaagcaagt gaacaaaata 2641 agacagatag tcacaggaaa ctcatatatt tataggtgct ttgcgtataa tgaagatggt 2701 ccttcaaatc agttgggaaa agatgggtta ttcaataaat ggtgttgggt aaaattggtt 2761 atacattggt gagaaataaa gtgaaactcc tactttgtat catatgcaaa aaatagattc 2821 cagacagatg aaatatttaa atgtaaaaaa taaaattcta aaactactag aaaaaaaaga 2881 agaatatttt tattcctttg aaatagaaaa ggtcttacta agcaaaacac agaagtaata 2941 aatgaataaa tgaagacaaa tatgataaaa ataagttaaa aatataagca atctttcttt 3001 gttttttttt cacctttcct agaaaaaaac atataggcaa cttgttaagc aaggtagatt 3061 acaagaaaat atttacaaca tttgacaggc cacagattat tatccagcct catctgataa 3121 gaaaacttca acataaagat atctgttttt tttcttataa ggttcctcaa agtgagccaa 3181.tcacttctta agctgaacaa aaaacaaaac agaagtgatc ttttccaata atgaaaacaa 3241 acattgacag agcagctgta ggaccctttc aggcaaatta tgaaaaggtg ccctttctca 3301 gaaaccacag ttaccattca gctttgtgac cagaggtttg actgtaccct agtccctact 3361 agcaacccaa ccacataacc aacttcaaag gtcctgaatg actgtgttgt acttaatggc 3421 agatgatcta tctcccattt ttgtcctaag gattttccaa gataatatat ttctgcattt 3481 gttttgcttt tacttcaccc caaattgaaa tctatttgtg ggataagact aaagaaatgc 3541 ttataggaaa attgatagca ccaaattcct atcttaaaaa atgaaaaagg tttcaaatca 3601 atgacctcag cttttacttt aagaaaatag aaaaagcagg ataagctaaa gccaaagtaa 3661 acagaagaaa ggaaattata aaqataagag cagaaatcaa tgaataaaaa acaaaagaaa 3721 aaaatcaaac caaacagccg attctttaag cagatctata aaattgataa aactctagcc 3781 agattgatca agtaaaaaag agagaagaca caaattacca gtattaagaa tgagagaggc WO 00/09525 PCT/US99/17712 EPI-109 852 3841 aatatcacta cagatcc:ac agatataaaa agtataaggg catactttga ataattttat 3901 gactataaat taggcaactt agataaaaca aatttcttga aagacacaaa caaccaaagc 3961 tcacctaaaa tactcacaaa ttgaatagtc ttatagctat tacaaaattg aggccaggcg 4021 cagtggctca agccttzaat cccagcactt tgggagggct aggaaggcgg atcacgaggt 4081 caggagtttg agaccaccct gactaacatg gtgaaaccct gtctctacta aaagtacaaa 4141 aattagccag gcttggtagt gcgtgcctgt aatcccatct actcaggaga ctgaggcagg 4201 agaattgctt gaacctaaga ggcaaagttg tggtgagccg agatcgcgcc actgcacttc 4261 agcctgggca acagaacaag actccgtctc aaaaaaaaaa aaaaaaaaaa aaattgaaat 4321 tatagttaaa agtcttccca caaagcaaac tctagaccca gatggcttca atggtaaatt 4381 ctactggaca atcaaacagg aaacagtaat aattctccac aatgtctttc ataaaattga 4441 tgcggaggag atactctcca actcattcta tgaaactagc attaccctga taccaaaatc 4501 atacagagac agtgtaggaa aacaacagat cagtatcctt catgaacata aatgaagtac 4561 aatgcagtct tatgcacaaa tcagagcttc attgttctac agataaggta atgtaggatt 4621 gttggttgcc cctccaggtc tgttaaattc acctccttcc ccagagagca tccttcttaa 4681 ggacagggag cctcaatatg tcagtcctca cagcacctcc ctcagtcttc agcacttacc 4741 agctcatcac cacaaccgat accacattgg ataatttcat gaattacttt agagcaaatg 4801 caagagaaaa aatggattt tatataggag aagaaggagg aaattcttgt ggatttggta 4861 cagaataggg ccaagggaaa attacagatg taaaaagaaa agtgtgtgaa atagtatcct 4921 tagtgctcac aaatacaatg atttcattgt ttttaaaaa aaaaaatgac aaatgtctaa 4981 tgcttggtgg taatgcttta ttgaatgtgt gttatacact ggttcctcat tcctgaagtt 5041 agaaataata ccttcctctt ttcatttggt tatgtttgct gaaacaaatc aaaggctgag 5101 attgaaacac atgctacttc aggtggatga ccttactact aagctcatca caacagcact 5161 tacagctgaa gaccccagag tcctacctaa cttttgtcac aacccagatt ttggccatgt 5221 agttctgggc cttaccatta aagcagacag aagtcagagg aatgactcct ttccacttga 5281 agtgagctgc aggcttctag gaaaggcaag atgcacattt ccctcctgtg gagcataaag 5341 cctttgtaat tcaggacata ggacccatat ggatttgaaa tattatgaca ttggagctgg 5401 agtggttggg gacaacacca gtagtgttat aggccatgga atgtcaaaag aacatggaac 5461 cctgttaaaa tcattaaaca tcaaaactct cccctcctct ggtgatatgg tttggctgtg 5521 tccccatcca aatctcactct tgaactccca tgtgttgcgg gaggcaccca gtgggaggta 5581 attgaatcat gggggcaggt ctttcccatg ctgttttcac gatactgaat aagtctcaca 5641 agatctgatg gttttataaa ggggagcttc cctgcacaag ctctcttctc ttgtctgcca 5701 ccatgtgaga catgcctttc accttccgcc atgattgtga ggcctcccca accatgtgga 5761 acttttaagt tcattaaacc tcttcctttt gtaaattgct cagtctcaaa tatgtcttta 5821 tcagcaacgt gaaaacagac tatctgattt tctgtgggat gtggattatg accatggaca 5881 gagcataact gggacagagc tggaaaaaat attaattagg tgcttaaaaa tatttgttag 5941 aactatcttc atgaatgaga atcaatcctg tttccatggt gattcaccag gcatcaattc 6001 caagcatcca tgaatcagaa aagtcctatc ttctcttagt tatcatccag gactccaagg 6061 aaccataatt agccaacctg ttcacatttc cttttcattc actagcctcg aagtttccag 6121 gggacaggga ctctgtccta ttcatttctg taaccttacc acctgaccca gaatagctgt 6181 tccctgaaga tttggtggat tataaatgtg gatgtcttat ttctttgaaa gtgtgagctt 6241 caggtactga tcacgttatt ccaattatca atttagtatc tttcttcacc attaaactgt 6301 gaaattcttg agggaagaac ctatgactga tttatctctg taaactcatg ccaccagtat 6361 tcaaaatcac acctagcaca tagtaaacac tcaatgtttg ttgaatgact gaaggaatgg 6421 atgaaaatga acctccttgc ttctgaccag tggatgagtt gcttggccgt gttcctacag 6481 cctagagctc atcccctaaa gcatctgaag ttacccatta gtgcaatggt tcttgaacgc 6541 tggtgttgat cagaatcatc tggatgccca ggttctctga aataagatag ggtctaggca 6601 tttgtatttt taccaaggag gtgtgatgga gtcagatgca agaaggctag ttgaagaaac 6661 cacatgagag tttagtgtag tgtattagaa gacggtttg gctctgtcgc tagtggctac 6721 atcatcttgc tcaagtcatg ccagtctcag gacctcattc agtctcttca gctgtaatat 6781 gggtgggttg caccacataa ccagaaagat cccttccagc tctacccact tacaacatgg 6841 tcaaatttgg tctgattttt taaatcgtag tacaatatat atgacataaa attcaccatt 6901 ttagccactt taaatgtaca attctgtagc attaactaca ttcacattgt tgtgcaacca 6961 tcactaccgt ctacttccag aactcttcat cttgcaaaac tgaacctctg ttgtcattag 7021 tcactaacta ttcctctccc cccctccttc taggccctgg caatcaccat tctactttct 7081 gtcgctatga atttgactac tctaggtaac ttatataagt ggaatcacag catttgccct 7141 attatgactg gtttagttga cttagcacaa cctcctaagg ctcaaccaca ttttagcatg 7201 tgtcagaatt ttctttgttt ttaaggctga ataatattct gttgtatctg taaataacat 7261 ctttattcat ttgtccaca acagactgtt gagttcctcc catcttttga ctattgtgaa 7321 aaatgctgct atgaacctga gtgtacagac atctggttga gtactgcttt caattcattg 7381 tttatatgga tcatatggta attttatgtt taattttttt ggaactgcta cattgttttc 7441 cacagtgtac atcatttac atttccatca gcaatgcaca aaggttccaa tttctccaca 7501 ttcttaccaa cattttttat tttctgtttc ttatttattt gtttatttat tctgagacag 7561 agtctcactc tgtcacccag gctggagtgc agcagggtga tctcagctca ctgcaacctc 7621 tgcctcccat gttcaagga ttctcctccc tcagcctccc aagtaaatgg aattacaggt 7681 gcccaccacc acgcccaggt aatttttgca ttttttttag tagtgatgag gtttcaccat 7741 gttggtcagg ctggtcttga actcctgacc tcaagtgatc cacccgcctc agcctcccaa 7801 agtgctggga ttacaggtat gaaccactgc acccaggcca ttttttgctt tttagataat 7861 agtcatccta gtgggtatga agtggtattt cattgtggtt tgatttata tttccctaat 7921 gatcagtgat attgagcatc tttcaagtgc ttattggcca ttttcttctt tggagaaatg 7981 tctatgcaag tcctttgctc attttttaat ccagttgctt tttgttattc tttttgattt 8041 gaaagtgttc tttatacctc ttgtatacta atcccttatc agatatgatt tataaatatt 8101 ttcttctttt ccatggattg ccctttttac tctgttgata gtgttctttg atacaaaata 8161 atttttaatt tgaatgaagc ccaattaatc tatttttgtt tcttttgttg cctgtgcttt 8221 tggtgtccta tccaagaaac tgttgccaaa tccaatgtca caaagctttt tcccatgctt 8281 ccttctaaga gttttgtagt tacagctctt gtatttaggt atttgactat tttgagttaa WO 00/09525 PCT/US99/17712 EPI-109 853 8341 tttttgtaca tcgtataaaa taagaatcca atttttattt tatttzactt tttgtatgtg 8401 gatatccaat trccccacca ccattcattg aaaagactgt ccttttccta tcgaatggtc 8461 ttggcaccct tgtaaaacat aatttgacca tatatgtgag ggtttaztc tgggctctct 8521 attctattct attctattct attctattct attctattct attctaztct attctattct 8581 attggtccct atgtctttct ttattctagt accaccattt tgctcatcat aactttgtag 8641 taagttttga agtcaggaat cgtaagacct ccagctttgt tcattttcaa ggttgttttg 8701 attattcaag gtcccttgat agtccatatg aatttcagga tggatttttc tatttctgca 8761 aaaaaaaaaa aaaaaaaaaa aaaaatcatt gaaattttta aacagaztgc attaaatctg 8821 tagattgttt tgggtagtat tgacatttaa caacattaaa tcttccaatc aatgaactag 8881 gctattttta tttatttttt ctgtttcttt gagctacttt tgtagtzttc aqtgtataag 8941 tttttgctac ctggttaggt atacttctaa gtattttcta cttttrgatg ctattgcaca 9001 ttgaatcgtt ttcttaattt ggtggtagcg gggattgtgc attgttagta cataaaaatg 9061 caactcattt tttgtgtgtt gattttgtat cctgcagctt taacaaattc atgttagttc 9121 taacagactt attctatgaA tcattagggt tttctacata aaagatcatg tcacctacaa 9181 acagagataa ttttactcca ccccttcccg ttgcaatgcc ttttatgtct ttttcttgcc 9241 taattgttct ggctaagact tocactacca tgttgaatag aagtggzgaa agtagacatc 9301 cttgtcttgt tccaatctta gaqccaaagc tttcagtctt tcacggcctg aaagactttg 9361 taatatgttc tcaaggttaa agaacttcag aagttttcta agcaagagac cattttatta 9421 acttagttgg cagcaattct gagagattag aatgaaaaga tagaggataa gaagtatctg 9481 gcaggtataa tatattgagt gtgctgaata tacttttagt tttgtatagg tgttaaaaaa 9541 tggcaaagga ggccgggcgt ggtggctcac gcctgtaatc ccagcacttt gggaggccga 9601 ggcgggcaga tcatgaggtc aggagatcga gaccatcctg gctaaaacag tgaaacccta 9661 tctctactaa aaatacaaaa aactcgctgg gcatggtggt ggacacctgt agtcccagct 9721 actcgggagg ctgaggcagg agaatggtgt gaacctggaa ggtggagctt gcagtgagcc 9781 gagatcacgc cactgcactc cagcctgggc gacagagaga gactccgtct caaaagaaaa 9841 aaaaaatggc aaaggaaaga atgaaaaata aagcaaggtc ccagaagagg ccaaaaatct 9901 taatcaaaat tgactgaaca ttacggaatg aaatggtttt tcctttactc caattaacga 9961 cttcacaaga agattccac ctcgtttata agattaaccc aaaaccagca cttaaaacca 10021 gaagccttga aaggatggag tttggggacc cttctcatgt ctattcccag aagggggtct 10081 tcttctgggg tcctgtcccc taaagagcta ggcaaaaagt atgcttgcca catctgttga 10141 aagatagaaa gttggtctaa aaatacatga gagggaactg aaacattca gagaaggcaa 10201 gactcagaag taagaaacca aaagaggaag gtaaaattct agttacaaag aaaagaggaa 10261 tggaaattaa attgtcttac agagaaaatc cagaactgcc ccctcttccc ttactactcc 10321 atcaaaaaag gggaaaaata gtcaatggga aagttttgag aaaaatagat ctctgcattc 10381 ttctggttga gaattcagac aacttgaact agagagctgg gtaatttctt gactaaaggt 10441 gtgttagatc tgaaagggtt tttcttaaaa ttgtctgtgt tcatccctcc catcttagag 10501 aggaacacag gataagagac ctctggagct cccccagggt caccgagcta ataggatcag 10561 agacaaagct acaaagtcat tttctgacat ctctccaggg ctcttttttt ctggaccccc 10621 catatcaaca tgatgtattt attacattgg attagcaact ctccttgagc tttcctcagt 10681 accaggttta catctcagtc tgtgggtctc agagaaagta cccaatcagc agcaacatta 10741 cctggaaact catcagaagt gcccctcctc agccccaccc cagatcatg caatcagaaa 10801 ctctggaaat gcaggccagt cctaacaagc ccaccaggga attctggtgc actaaggttt 10861 gagatccact gatcaaagaa ataatattcc ttttcttcat tataatagca tgaataataa 10921 ctaacatgta tttcacaatt tacaaaagag ctttatgctc ttgttaaatt tgagggtagt 10981 cttctcaaaa tctctgtgag gctagaaagt cagatattga aacacctgtt ttatgggttc 11041 aaagataggt tcaaaagaga gtaaatgatt gttggggtgg caggtccaga gagggcagga 11101 tcaaaactgc aattgagtct tctgccttat aaaccagcat agcttcccca aggcacgtca 11161 cttctcgata aaatggtgac aactagagtg tcctttcaga tcattcttag aagcatggag 11221 tgctaggtca attgtgtaat tgatgaggaa ataataatac taagaactcc catcttctac 11281 gtccttatat acaatcctgt caggtagaag ctgagtctca gagagaacaa gttgccctcc 11341 caggaccacc aggtaagctc ggcatagctg tgcttagaat gtaggcrgtc tggcttctgg 11401 gcttgcctgc ccagggaggc tttgtgggtt ctacttggtc atccagatca cagaggggca 11461 gcactgactc ctacccagtg ctcttgactg tacatctaat actttctact aagaaaaccc 11521 cttctcttta gaccaatggt tttcaaatct tggtgtgcat tggaatcacc tggaaagctt 11581 gttaaaacac agattgtccc accccaagag tttctgattc tgtaggctgg ggtggggacc 11641 catgaaagtg catttctaat aaggtcccaa gtgatgctga tgccaccagt gtgtggacaa 11701 ccctttgagt ggtgaagctc tggacaccct aatttgcaag gctaatcagg catatgtggc 11761 aaatgaatac gaactgaaat tctgactcca atatcttcac tgatattcct aatccatagc 11821 atacacacag tcccatccgt ttccctttta gcttttaatc tacatttatc ctttcttcct 11881 ctgccactgc cttctctcca gttagctcaa accaggtaac acataaccgc ctcctaactc 11941 atccgcccag ttggtttctt tggctttaat ctagacttct tatctccacc agatttgcct 12001 taccaaagca ccaatttctt aaggcagggt tagaattaaa aatcttctgt tcctcctcat 12061 tgcctaaaac tcctaaactt atgattcaag gtcttccatg accttcatgg accagtctaa 12121 cgttttagcc tgtcctaagt gacatgcctc caccacatac ttcatgcttt ccactttctt 12181 tctccatgtc tttgttcatg catttccatt tcttctacct gcgatatcct ccttcgccat 12241 ctctgtagat ttaaaaatcc tacagggctc atctcaaatg cccttrcctt catgaagcct 12301 tccatgaaat ccccatcgag aggttttccc tcctctcagc tctccaaagc acagatgtct 12361 gcgtttgtgg ctattatctt acgttgtttt gtattaaaat ttctccagct ttacacattt 12421 gtcatcctct taaggacaaa catcttatta tggcaatgt gaagctatag aggataattt 12481 aatgaaatat tccaagggct agtcattaca catgactgat ttatctctgt aaactcatcc 12541 acactcatcc acctgatttt gattggccaa gttaatgaat cagagaggaa aagatggtaa 12601 aaatataata aaaatctcct aggtagtctc acatcccaca gagccccagg taatgaaatg 12661 aggccctgag ataatacttt atgaacaata aaactccggg ttctartgac agtgaagcaa 12721 gacctgagag agaaggctaa attcccttgt gtccagctgc cacaatcttc tgagaataat 12781 ggcctttctt cccgtctgcc ttctgaatca taggcaaatt tttctctcg gctgatcccta WO 00/09525 PCTYUS99/17712 EPI-109 854 12841 atacagaaag gggaagtcaa ataaaatata tacaaggaga aggattctgg gagacagagt 12901 ttcttgattc ccttctgcat gctcctcctc aaaagccttt atgagcttac cttacattta 12961 aattctttta aacaaggcat tatgtggtct ggtcttttcc agctccacac accttcacac 13021 tacattcccc ccagctaatt ctgctctggg aacactgacc ttcttttagt tctttgaaca 13081 cattgatttc tggtcaagat gactcagtaa cttcaacctt tgttgtgccc ttggtgctgt 13141 gaagatatag atatatatta accactgcac accagaaatc agaaatagca caacagagaa 13201 taaagtcatt gagccatctt ctgagctcca aaagacaaat tttctccaaa aagacaaatt 13261 caggctctaa aacaatacct taaggaacca gaagtggaat agaaaattaa ggtggtaagc 13321 agggctaaac cacatgcctg ttgagcccag gtttggaaga agacaatggc aggtaggaat 13381 gtggtttcta atgggtaata ggtactgttt tcatttactt tctgttgctt ataacagaat 13441 atctgaaact gggtgcttta taaagaaaag gaatttatgt cttgcagtta gggaaactga 13501 gaagtcaaaa gttgagggct gcaattgaca agtgccttct tgctggtggg gatactctga 13561 agagtcttga ggtggtatcg ggcataccac tctcagtgag gggactgagc atactaggtc 13621 aggtctttct tcctcctttt ataaagctat cagtcccact cttatgataa cccattaatc 13681 cattaactga ttagccaatt aatccatgaa tggattaatt cattcatgag ggcagagcct 13741 tcctgaccca aacacctctt aaagactcca cctctcaata ctgccacatg ggggattaaa 13801 tttcagcata agtttttgat gagacaaata ttccaatgat agcagttatt aaaagtacat 13861 gcttgagaga aggggattgg agtcagcctc agtgcttaaa ctcaaaagct aggatgaggc 13921 tctaacactc ctgaaagaag gagttgctgc tggctcctta ccagggctat atcttttaca 13981 gagcaggaga cctaaagagg caggaggacc cggacatcgt ttggaaacca agcactaaaa 14041 caggccatct gttatacccc caatatcctc tcaggacaag tgttttgaac cactcacaca 14101 aggactagtc tgggcaagtg ggctagatga agaaaccaca aaatagctaa gtggggagag 14161 aaagaccaaa aatactattt tattcaaaat gaaaatacaa tccaaaattc catgattcat 14221 gaagaaatca aatggtatgt gttaggtggt tcttgcattg ctatagagaa atacctgaga 14281 ttgggtaatt tataaagaaa agaagtttaa ttggctcata attctgcagg cttcacagga 14341 agcatggtgc tggcatctgc tcagcttctg gagaggcccc aagaagattt gctcaaggca 14401 gaaggttaag ggagagctgg cacatcacat ggtgagaaag gaagctagag agagagtgca 14461 gggtgaggtg ccacaagtta ccacagccag atctcttgag aactcactta ctttcatgag 14521 gacagcacca agccataagg tgtagggagc caaagtccca tgggacatga ccaactcagc 14581 attccactgg aggctatatg atcaaacagc aaactgttta tcacgaatgc aggatgtgag 14641 caaactcaca actggtcctg ccaacagaag gtttgttgga ggcaatcact ccctggtgcc 14701 tgaggtaatc tactgcaaca tctagagaat gcagtcttgc aagcctactc tggacagggc 14761 agctggcacc ttattccatc ccccttctca ctatcttttt ttgcctaata aatacagagg 14821 gctgtgtaaa gctcagggcc cttgtccact agaggcaagt tgccccctga ccccttcttc 14881 caaatatact cttttgtctc ttgtctttta ttctcacatt tgcccccttt gttcagttcc 14941 actaggtccg tgcgggttat atactggtgc cctgagcagc aacagaatca ggctctcaac 15001 aagtgtcatc cgaacatggg actttgagga catgaacgaa gaaggtctgc tggagcagag 15061 gaacagaaat tgacaaggtg aacagggacc ctgggacgag tctgccagca gcggatataa 15121 ggtcagttac ctaaagaggt actgatcagt gccctaaaga gatactggga gcagtgcttt 15181 aaagaagtac tgggaatggg aaattttctg aatcagggta acaaggggaa gaatttgtct 15241 attaaagaaa aacattatgt gcagttgctt aaagttgtat tggaacagtc tggagcttag 15301 gttaatttgc agacactaac tatcacatgc gtccgtgtga agagagtcca ccaacaggct 15361 ttgtgtgggc aataaagctt tttaatcacc ttggtgcagg tgggctgagt ccaaaaaagg 15421 agtcagcaaa gggagataga ggtggggcag ttttatagga tttgggtagg tagtggaaag 15481 ttacagttaa aagtggttat ctcttgtggg cagaggcagg ggtcacaagg tgctgggtgg 15541 ggaaatcatg agactctttt tctgggacag gagtgtcaca aggtcaattg atcagttggg 15601 gtggggcagg aacaaatcgc aatggtggaa tgtcatcact taaggcagga actgactatt 15661 tcacttcttt tgtggttctt cagttgtttc gggccatctg gatgtatagt gcagctcaca 15721 ggggatataa tggcttaggt tgggctcaga gacctgacat tcctatcttt ttatattaat 15781 aagaaaaaca aaacaaaata gtggttaagt gttggggcag caaaaatttt ttggggtggt 15841 atgtagagat aaggggcaat gtttctcagg gctgcttcaa gcacgatcac ggtggtgtgg 15901 gaatctagag tgggagagat taagctgaag aaaaattttg gggaaagggg tgatattctg 15961 gggttgttag aaggagcatt tgtcatatag aatgatgatg gcctggatgt ggttttgtat 16021 gaattgagaa actaaacgga agacacaagg tccaaataag agaaggagaa aaacaggcat 16081 taaaggatta agaattggga ggacacagga catccaatta gagagtgccc aagggggtcc 16141 agtgtaatta tttgcctgga caatgagttt tggggctcta ttaggttgtc atataccagg 16201 ccagattgat ttaggtaaaa acaacactct tcatttaaaa tatacagagt cctccttttt 16261 tagcagtgag taagttgaga cctattcctg tcttcttata ttaataagta aaataaagca 16321 aaatagaggt gaagtgttgg tgtcatgagg ggaacaggaa gcagttcggt cctatttgca 16381 aattgatttt gggggggtaa agaaaactag tgtacctttg cctgtccaat taataagtag 16441 acacatgtag atggaggagc cacagaggaa gaagagaact ttgtaaggca aaactggaaa 16501 tgtaaaggga aaagatgaga gggagcacca aaagaggtgt cttgcaccca gactcaggga 16561 tctagtgaga gcagcagctg ttagaggttg taatggggat taatggggct actgggtaga 16621 gggggaggtt caacttttat ggtgtatgag aaagcgcata gtgtctacaa gcaacctttc 16681 attgctattc ataggattgg gtataagtaa acaagaaggg ggggctagga ggagagtctg 16741 aagaacaagg ggaaggtagc caaggatgga gtgaaatgta gggcaaatgt cttaaaggaa 16801 atgagaggtt ctaagaggag ggctagtggc ttgtaaccca catggaagag gttacgaaag 16861 gatgatagaa tggaatgagc ctgtgaggct ggaaggagga attttccttg gtccaagaac 16921 catttgcctt gtgtgggaag agtttgatag gtggaagttt cagtgggagg gtaggcggga 16981 gtgactgatg agaaggagaa aaactggcca taagggacag aagttggaat gctagctgct 17041 cctttagcta ccttatcagc ataagctttg ccctgagtga tgggatctga tgccttttga 17101 tggcgcttgc agtgaatgac cctagcttcc ttggaagtag agcagcttta agaagagttt 17161 ttatgaagaa ggcattaata atggaggacc ctcgtatagt gaggaaacct ctttcaggcc 17221 atataacaga atggaggtgg agaatatgga aggcatattt agagtcagta taaatactga 17281 cacacaatcc ttttgcaaga gtgagggctc gagttaaggc aatgagttcg gcttgctgag WO 00/09525 PCT/US99/17712 EPI-109 855 17341 agggagtgga gtggggcaga gtggtagcct caatgataga tgtgaaagat actatagcgt 17401 agcctgcctt tgctggtgag tggtgattag gcctagtgga actgccatca ataaaccaag 17461 tgtgatcaga gtgaggaaca ggaaagaagg aaatatggga aaatggagtg aatgctaggt 17521 ggatcagaga gatacagrca tggggatcag gtgtggtatc aggaataatg tgggaggcca 17581 gattgaagtc caggccaaga acaatggtaa ttgtgggaga ctcaacaaag agtgagttca 17641 actgaaggag ccgggggagg gggagagcgg cagaaagtat atgcatcagg tgtgaggaag 17701 aaaatacatt ttgaaagtta tgagaactgt agagagtgag ttgatcatag tttgtgattt 17761 tgagggcctt taaaagtatt aaagcagtgg cagctgccac acacagacat gagagccagc 17821 ctaaaacagt aaggtcaatc tgtttagaca gaaaggctgc agggcactgt ccaagctctt 17881 gtgtaaggat tctgaccgca cagccttgta ctttggctgt gtgtaatgaa aagggttggg 17941 atgagttagg gagagctagt gtgggagtag cttctagggc tgtttttaag gaacataaag 18001 aggagtgggg aaaggattta ggatctatgg ggtcagctag gtttcctttt gtgagtttat 18061 gtaatggttt agtcaggatg gcaaaaccag gtatccaaag gtgaaagtac ccaaccatgt 18121 ctaggaagga aaggattrgt tgctttgtag aagggattgg ggtttgggag attagccgga 18181 cacagatcag gagggagagc acttgtattt ttatgaagaa ttatgccgat aggtaacgga 18241 tgaggaagaa atttgggctt tggaggggga tacacgatat tcccttgaga atagatgttg 18301 gaggagcagg agggtgtcct gttgggaaga ttcataggag gggctataaa gtagaaggcc 18361 atcaaaatat tgaataaggt gacaagcaga tggacagaaa agtaaattat gagaaagggc 18421 ttgactgaag taatggaggc tgtccctgaa gccttgtggc agtacagccc aggtaagttg 18481 ctgagactga tgggtgtcag ggtcagtcca agtgtaagtg aagagaggct ggggtgaaga 18541 gtgcaaagga atagtaaaga aagcatcttc aagatccaga acagaataat gggttgtgga 18601 gggaggtatt gaggatagga gagtatatgg gtttggcacc acagagtgga taggcaagac 18661 aatttggttg ataagctgaa gatcctggac aggctttagt cccttcaaag cctgttgtgg 18721 gatgggatac tggcattgag caggataagg gtaattaggt tttaatggga tggtagggtt 18781 gcgtgatcgg tcaccaagga gggagtagag gtatcccata cttgtgggtt aagataggga 18841 gtcaggaggg gaggttgtga aggaggcttt gaactgggga aaagggtggc aatgaggtgt 18901 ggctgtagcc caggaatagt cagggaagca gataatttag ttaaaatgtc tcaatttaat 18961 aagggagctg ggcaggtggg aataactaaa aaggagtgca taaaagaatg ttgtccaagt 19021 tggcaccaga gttggggagt tttaagaggt ttagcagcct gaccatcaat aaccacaaca 19081 gttatggagg caagggaaac aggcccttga aaggaaagta atatggagtg ggtagcctcc 19141 atattgatta agaaagggac agacttaccc tccactgtaa gagttaccca aagtgtctgt 19201 gatgatccag gaggcttctg aggtgatcag gcagtgtcag tcttcagctg ctaagctgag 19261 aagatctggg aaggagtcag tcagagagcc ctgggccaga gttccagggg ctctgggagt 19321 ggctgacggg caagttggac agtccgattt ccaatgcggt cccacacaga tgggatacag 19381 tttaggagga atcctgggct gtaggcattc cttggcccag tggccagatt tctagcactt 19441 gaagcaagat cctggaggaa tgcctgacca cagtggttta ggtgttttga agttcttgtg 19501 tgctggagat gtggctgagg tttttctcac agcagaggca agtaattgca actcagaaat 19561 acattgccac ttggctgtct cttctctatt attgtacacc ttgaaggtga ggttaattaa 19621 gtcctgttgt ggggtttgag ggccataatc taatttttga agctttttta atgttgggag 19681 tggattgggt aataaaatgc atattgagag taagacagcc ttctggcccc tctgaaccta 19741 gggcagtaaa atgtctaaga gttgttgcca aagggaccat ggactgggct gcgttttcat 19801 atttgatgaa aaaaaaagag cctaaatgct aactaatttg ggagaggtca gataaagtaa 19861 aaggaacatt aatcttgact atgccttcag ctcttgccac ctctctaaga ggaaattgtt 19921 gggcaagtgg aggagtgcta gtcgtggaat gaaaccataa gctggactgg gtgtgaggag 19981 gggaggtgat agaaggatta cagcgtaggg gagtagaggc tgaggaagaa ttgggacctg 20041 gctcagcctg gtgaggagtg gcctggtgag gagcagcctg gggaggagga gagaggttag 20101 atgggttcgt agaaaagaag gattcaaagg actcggagct tggtgaggag actgaaggaa 20161 cagacaggag agaaagaaga aagatttggg acaagtcgca ttgggagcag agactaggaa 20221 gggagtgatg tgtaaagaat gcctggacat caggcacctc agaccatttg cccattttat 20281 gacaaaaatt atctaagtct tgtagggtgg agaaatcaaa agtgccattt tctggccatt 20341 tggaacaatt atcgagtttg tattggggcc aaatggtgtt gcagaagaaa ataagatgct 20401 taggttttag gtcaggtgag agttgaagag gttttaggtt ttttagaaca caggctaagg 20461 cagaagaagg aggaatggag ggtggaaggc tgcccataat aaaaaggtaa gtttagagaa 20521 aagagaggat agagacacag agagaggggg tggtggtact catcagccag gggaggtggt 20581 acttgccacc aaggtgatgg atcaaggcag tcatccccac ggtgatcaga cacctctgaa 20641 atgtgggtga ataatcaggc aggtgtccct gcagtgatta gacaccaagg ggagactgtc 20701 ttcccgagtc cgtgaccggt gctggagttt tgagttcaca gataaaacac atctcctctg 20761 tctctaccag aaagggaaa5 gaactgaaat taaggaaggg agagattgaa gggtggagag 20821 atagcaagag agttggaaaa gagaataaaa agaggccact tactcaattt aaaattggtg 20881 agatgttcct tgggctgatc tgaggaccca aggttgtagg tggatctcct cacggaatga 20941 gggtgaggac aggggactgg tctccagaag gagttcccga gtcctggatc ttcagcacca 21001 aatgtcatgt gcatccatgt gaagagagtc caccaacagg ctttgtgtta tcaataaagc 21061 tttttaatca ccttggtgca ggtgggctga gtctgaaaaa ggagtcagca aagagagata 21121 ggggtgggtc agttttataa gatttgggta ggtagtggaa agttacagtt agaggtggtt 21181 atctcttgag ggcagaggtg ggggtcacaa ggtgctgggt ggggaaacc tgagacttat 21241ccatccaggga aggagtgtca caaggtcgat tgatcagttg gggtggggca ggaacaaatc 21301 gcatggtgga atgtcatcag ttaaggcagg aactcactat ttcacttctt ttgtggttct 21361 tcagtttctt caggccatct ggatgtacac gtgaaggtta cggggatata tgatggctta 21421 gcttgggctc agaggcctga cactaacctc ctgcagaagc cacaaaaggt tattacacat 21481 aaaccatggt ttccacaggc aggcactctt gatgtggaaa attgggatag agcaggatta 21541 aaacaagctc atcaaaaagg tcttaaagtt gattcttcag ttttctccac ttggagttta 21601 gttcatactg tacttctgcc attatctcct tattattctg cggaacagca ggctgaatct 21661 aaaaattgga aagaatttgt tgtcctactc acagctccaa ttgaatataa aaaacaggag 21721 agggaggata aaaattggcc tataccgcct cctccagatg cagaaacatc tgtaccatct 21781 ccttcagtgg cagaaataga gatcccagta caaagaattt tatgctcgc tgtcatagct WO 00/09525 PCT/US99/17712 EPI-109 856 21841 ggagagccct taggaccttg tgcttttcct atttctgtaa ggcctgatcc aaataatcca 21901 cagcagttta ttcatgaaca ctctccacta gaatttaagt tgttgaagga attaaaaact 21961 agtgtggtca ataatggagt acaaagccaa tggttcctgg aggaaggaat gctaqacata 22021 gaactttggg agcaagtagg gagaaatctt aaacaacacc aggcacaaag gcatcaggtc 22081 ccagtaaaat cttttatgtt aggggctttg agtagagcag ccctggttgt tacacacaaa 22141 aqagcctaaa aagggaaagg aggaggaaat gtcacctgcc ttatcacctc cccttccctc 22201 agtgccaata tcactgggcc aaaataacaa agaggaaatg gaggtcttac ctaagcttcc 22261 tcctccaata gataggaaga aggacagagg atacgctaca gctatcagtc cctgtcttaa 22321 gcaggcagca ttagaaggag agctcttagc cgggtgcagt ggctcatgcc tataatccca 22381 gcactttggg aggccgaagc aggcagatca tgaggtcagg agatccagac catcctagct 22441 aacatggtga aaccccgtct ccactaaaaa tacaaaaaat tagccaggca tgttggtggg 22501 cacctgtagc cccagctact tgggaggctg aggcaggaga atggcatgaa cccaggaggt 22561 ggagcttgga gctttcaatg acctgagatt gcaccactgc actacagcct gggcaacaga 22621 gcaagactcc atctaaaaaa agaagaagaa ggagagctct taacctgctc agtaatgcaa 22681 aatcggcaag gcaatcaggt gtatgtttat aaaaagataa gaaaaaggca ttagaagcca 22741 aaaccacgtg gccaagcagg cagtgggcag gagaaaatgc tcagaggcag aaaagctcac 22801 agcgacaaag ccaacaaggt ctgcccagga cggcagcatc cctctggcaa aggagcaagg 22861 gagcagcaca gacacaggca aagcctaaac aagtacaatg tggccacctc ccaggacctg 22921 caccactgcc ctctggctct gtgggcagcc cattgcaaaa tttcatgtgt tacatctcag 22981 gctatgattc tctgctaaga tgtaagtaaa atgtaagaat ttgaaaagca tcttttctaa 23041 taatggccac tattgtcatc tctctcctat ccctgatgta gctttccaaa ttcaatttaa 23101 gtaaaacagt aacctttgaa gggaaagaga ttacagaggg cccatgaatt agttgaagag 23161 taattaaaag ctaggcatgt aaaaccacac attacgcttt aaagaagaaa tttaaaccta 23221 attaaatgat atttgttaaa ttagaaggta aaaatgttgt gccctgttgg gaacaggccc 23281 ccaaatctgg cataaactg gccccaaaac aggccataaa caaaatctct gcagcaccat 23341 gacatgtttg tgatggccat gatgcccacc ttgaaggttg ttggtttact ggaatgaggg 23401 caaggaacac ctggcccacc cagggcagaa aattccttaa aggcattccc aaaccactaa 23461 tgatagcatg agcaatctgt gccttaagga catgttcctg ctgcagacag ctagccagag 23521 cccatccctt tgttttggcc catccctttg tttcccataa ggaatgcttt cagttaatct 23581 atgatctata gaaacgatgc ttatcactgg cttgctgtca ataaatatgg gagtaaaact 23641 ctgttcaggg ctttcagctc agaaagccat aagccccctg atttcccact tcccaccctt 23701 tatttctgtg tgtgtgtctt gaattcctct agcgcctctg ggttatggtc tccacaacca 23761 cgctggtctt ggcagtgccc ttctcagaaa gtgaaaaaga gttgtatgta agtgtagtga 23821 aaacataagc atgaatcact gtcttaaccc actgattaga tagtctttga tttgtacttg 23881 ctaaaagagt cctaaattga gttcctcagc tagtgagtca ctgttttcaa gactgtttgc 23941 cagattgaag tccataaact tggtcagccc gaaaactcaa ttacaagatc taagctattc 24001 tgcctgtggc tttaagcaca tggttaaagt atattattta agtctctcct tctagatatg 24061 ctttcagatt ttctttttaa acttcttgtt acttatttca gctttccata ttgataatta 24121 atgcagtcaa ttgctcagtt atgactgtga tatcatcagg attcctttaa gtaaaaggca 24181 attcaaagcg gtattgcact cccccatacc taatgcttta acactgttta ctgatgggtc 24241 tggtaaacat ggaaaagctg cagtctagta gagaccacat aattcaatca ctcgatctga 24301 gttcactagc actcagagag ctaaggttac tctgtttatt tattaaagaa tttttacaac 24361 cttaagctca ctctggactt tccagcctta tgtggcaaat gtagccatca atttatgggg 24421 tcaagactta cttacagcat gggatatgag gcttacaaat gagactttga taacccagga 24481 ttttaaatgt tgaagaacac gggatatcag agtgaaaaag gtttagggaa aattctgaca 24541 agggaaaatt ctaacctgat atcaataact ggaaagacag gttaaaccct gcaaggggat 24601 acattgacat tttttcttcc tcacttgctc ttttctgctg tctgaatatg ggcatgaggg 24661 caagagtcat tttagaccac caagtgacct tgaggataga agccttatac tagaggtggt 24721 gggaaagaaa aaacagaagg actcaaaag aaaaaaataa taaacctcag tattaagatg 24781 gaaaaattcc cccaattggt ctataggttg aacttcatct ctattaaatt tcagctatgt 24841 ttttgcagaa tttgatatgc tgatcataaa atttatatga aaatgcaaga gacacagaat 24901 agtcaaaact ttgaaaagaa gaaagttgga ggacttacac ttgttgattt taaggctttt 24961 tacaaagcta taataatcaa gacaatgtgt tactgacata atgatagaca tattgatcaa 25021 tatagacaat ggatgaatgg agtagaattg acagtcgaga aataaaacct tatatatatg 25081 gtcaatttat ttctttatgt attctgtcat ccagaataca taaagaacac cttcaactca 25141 ataacaacaa taccaacaag ggtgccaaga ccaatcaatg gaggaaataa tagtcttttc 25201 aagaaatttt gctgagacaa ctaagtattt atatgcaaaa taatgagttt gaatggctac 25261 catatacaaa aattaactca aatggactat attaggtcag tgcaacagta attgcagttt 25321 accaccatta cttgtttttt ttttttggtt tttttttttg agacagagtc ttgctctgtc 25381 acccagacca gagtgcagtg gcatgatctc agctcactgc aagctccact tcctgagttc 25441 acgccattct ccttcctcag cctcctgagt agcgggact acaggcatct gggtaatttt 25501 tttgtatttt tagtggagat ggagtttcac catgttagcc aggatggtct caatctcttg 25561 acctcgtgat ctgcccacct cagcctccca aagtgcggg attacaggca tgagccacca 25621 cgcctggcct accattactt ttaatggcaa aaatgcagtt acttttgcac caccctaata 25681 gaactaaatg taagagctaa aactacaaaa ctgttagaag aaagcatagg agcaaatctt 25741 aatgacatga gagttggcaa ttggttttta gatatgacac caaaagcatc aaggacaaaa 25801 gaaaaaaatg gataaattgg acttcctcca aattaagaga acttttgtcc tgcaagcaat 25861 actattaaga aagtgaaaag acaagtcaca aaatgggaga acatttttgc acataatata 25921 tttaataata ggctgacatc cagaatacat aaatacctac aactcaatac caaaaagaca 25981 gcccaattta aaaatgggcc aaggatatga ataaacattt ctctaaagaa gatacaaaaa 26041 tggtcaatat gcacatgaaa agatgctcaa tatcaatatc tattaggaaa atacaaatta 26101 aaacacaaaa tataaaacac aagatatcaa tttacactca ccaggatggc tgttatcaaa 26161 aagacagata acaagtattg gcaaggattt ggggaaattg taaccttcat acattgctgg 26221 taggaatata aaatttgcag caggtttgga aaacagttta gcagtttccc aaaaagcctg 26281 ggcatggtgg ctcatgccta caatcccagt gctttaggga gctgaggtga gaggattgct WO 00/09525 PCTIUS99/17712 EPI-109 857 26341 tgagcccagg agttggagac cagcctgagt aacacagtga gacctctttt ctaccaaaaa 26401 gaagagagtt aaacataggg taccatataa gccagcaatc catctcctag atatgtaccc 26461 aagaaagttg aaaacatata ctgacacaaa aacttacata tgaatcttca tattagcctt 26521 ataataatag ccaaaaagta gaaacaaccc aaatacccat caactaatta aaatatggtg 26581 tatctataca tattatttgg ccataaaagg aagtactgat acatgtcata acacaaatga 26641 accttggaag cactatgatc tctgtattag tcagctcttg tattqctata aagaactacc 26701 tgagactggg raacttataa agaaaaaggc ttaattgagt cacagttcca caggctgcac 26761 agggatcatg gcccaggaga cctcaggaaa cacagttatg atggaaggaa gagagtgaag 26821 gaggaggtgc tacatacttt taaaccacca gatcttgtga gaagtcactc actatcatga 26881 gaacagcaag ggagaagtcc acccccatga tccagtcagc cccagccagg ccccaactcc 26941 aatattgggg attacaattc cacatgagat ttgggtgggg acactaatcc aaacaatatc 27001 attctgcccc agcccctccc aaatcctgtg tccttctcac attggaagat acaatcatcc 27061 cttctcaaca gtttcatttc agtattaact caaaaatcca aagtctcatc tgagacaaga 27121 caagtccctt ccacctatga gcctataaga tcaaaaagaa gttagttact tccaagatac 27181 aatggaggta caggcattgg gcaaatatat ccattccaaa agggaaaaat tagccaaaac 27241 aaaggggcca caggccccac gcaagtccaa aatcaagcag ggaaatcatt aaatcttaaa 27301 gcttcaaaat gatatccttt gactccatgt ctcacatcca ggccacacca atgcaaggag 27361 tgtgctccca aggccttggg cagctctacc ctgttgctct acagggtata gcccccatgg 27421 ctgctttcac aggctggcat tgagtgcctc cagcttttcc aggtacacag tgcaagctgt 27481 tagtggatct accattctag ggtctggaag attgtggccc tcttctcata gctccagtag 27541 acagtgcccc agtggggaat ctgtatgggg gctgcaaccc cacatttctc ctctgcactg 27601 cccaatagag qttctccatg agggctccat tcctgtagca tacttctacc tggacatcca 27661 ggtgttttca tacatcctct aaaatctagg taggggctcc caagccttaa ctcttgccct 27721 ctgcacatcc gcaggcttaa taccacatgg aaaccaccaa tgcttatggc ttgcacccta 27781 tgaagcagta gtctgagaca tatctgggcc cttttggcca tggctgggat gcagggaaca 27841 gtgtcctgaa gtggcacagg gcagcggggc catgggcctg gcccatgaaa ccttctttcc 27901 tcctaggcct ccagacctgt gatgggaggg tctgcctcga cggtctctag aatgtgtttg 27961 aggcatattc ctcattgtct tggctattaa tatttggctc ctctttactt atgcaaattt 28021 ctacaqcctg attaattcct ttccaaaaaa atggggtttt cttttctact acatggtcag 28081 gtcacaaatt ttccaaactt ttacgcttcc ctttgaaatg taagttccag ttgcaggtca 28141 tttctttgat cacaaatata agcatatatt tgtagaatca gccaggccac atcttgaatg 28201 ttttgctgct tagaaactgc ttccaccaga taccctaaat cattgctatc aggttcaaaa 28261 ttctacatat ctctagggca agggcacaat gcctccaaga cctttgctaa tgcataagaa 28321 aattgacctt tgctccagtt cccaataagt tccccatctt catctgaggt ctccttagcc 28381 tggacttcat tgtccatatc agtatcagca ttttcatcac aataatttaa ctagtctcta 28441 agaagttcca aactttccct tatcttccta tcttcttctg agccctccaa actgctccaa 28501 cctctgccca ttacccgggt tccaaagctg cttccacatt ttcggtatct ttatagcaat 28561 gctccattcc tgataccaat tttctgtatt agtctcttct cgcactcctg taaagaacta 28621 cctgagactg ggtaatttat aaagaaaaga ggtttaattg actcacagtt ccacaagctg 28681 tataggaagc atggttcaga aggccacagg aaacttacaa tcatggagga aggcgaagag 28741 aaagaaggca cgtcttacgt ggctggagta ggaggaagag agtgaagggg gaggtgttac 28801 acacttttaa acaaccagat cttgtgagaa ctcactcact atcatgagaa cagcaaggga 28861 gaggtctgcc tccatgatcc aatcacctcc taccaggctc ctcctccaac attggggatt 28921 atgatttgac atgagatttg ggtagggaca caactccaaa ccatatcaat cccatttata 28981 tgaaatgtcc acaatagata aatctataga gacataaaat agattggtgc ttgcctagtg 29041 ctggacgtga caggagggtg tgagtaaaag aggcaatgga gtgataggta cagggtttct 29101 ttttggggtg atgaaaatat tataaaatta gattgtggtt atagttgtat aactcttgaa 29161 tatcctaaaa atatattgaa ttttccattt ccattttaaa tgggtgaatc ttatggtatg 29221 tgaattatat ctcaataaaa ctgcaaaaaa tgcacaattt gcaattgcaa aaatatggaa 29281 ccagtccaaa tgcccatcaa tgagtggata aaggaactgt ggtatatata tatatatata 29341 tatatatata tatatatata tatatatata tatatataca cacacacaca caccatggaa 29401 tactactcag ccataaaagg gaataaaaca atggcattct cagcaacctg gatggaattg 29461 gagaccatta ttctaagtga aataactcag taatggaaaa ccgaatatca tacattctca 29521 ctcataagtg ggagctaagc tatgaggatg caaaggcata agaatgatat aatggacttt 29581 gggaactcag ggaaagggtg agagaggggt gaggaataaa aggctaccca ttgggtacag 29641 tgtacactgt tcaagtgatg gctgcaccaa aatctcagaa atcaccacta aagaacttat 29701 ttacataacc aaataccacc tgtttctcaa aaacctattg aaattaatta atttttaaaa 29761 actgctgaaa tcaatagtga aaggatggac tattcaataa tgacacagtt aattgaatat 29821 catattttaa aaattagatc cttacctcac actataacat aacaataaat tccaggtgaa 29881 ttatagacca aatatgaaaa gcaaaatttt aatattttag aagacaattt ttatgacctt 29941 aagttagaaa atgattttta aaaacaggat gcaaaaacac taatcataaa gagatatttt 30001 aggccaagca tggtggctca cacctgtaat cctagtactt tgggaagctg aggcaggtgg 30061 atcacttgag gtcaggagtt caagacaagc ctggccaata gggtgaaaca tgtctctact 30121 aaaaatacaa aaattagctg gaaatcgctc gaacccagga ggcagaggtt gcagtgagct 30181 gagattgtgc cactgcactc cagcctgggt gacagagaga gactccacct caaaaaaata 30241 aataaataaa aataaagaga gattttaata aggtgcatta aaataaaaaa ctatccatca 30301 aagacaccat gaataaagtt aaaataggcc acaatgagaa tatatttgcc atgaattttt 30361 tctttttttt tgagatggag tcttgctctg tcacccaggc tggagtgcag tggtgcaatc 30421 tcggcttact gcaaacttca cctcccaggt tcaagcaatt ctcctgcctc agcctcctga 30481 gtagctggga ttacaggtgt gtgccaccat gccggctaa tttttgtatt ttttgtagac 30541 acggggtttc accatgttgg tcaggctgag ctcaaacccc tgacctcgtg atccaccttc 30601 ctcagcctcc caaagtgctg ggattacagg catgagccac cgtgcctggc ctaccatgaa 30661 tattttttta aaggtagcat ccagaattaa taatcttctc caacaaattt cattagtagt 30721 cagggaactg caaattaaaa tcaaagtaaa atactacttt ccactcatta gactaaaatc 30781 cattcaagtc zgataatacc tagtactgag ttggagtaat agaaactgct aatgggacag WO 00/09525 PCT/US99/17712 EPI-109 858 30841 ttagttggtc atcactttgg agagaaatta gtcagtatct agtaaaagtt agtgatacac 30901 cttccatttt catctgttct gtgctgctac caaagaatac ctgagactag gtaatttata 30961 aataatagaa atgtatttct aatggttcta gaggctgaga agtccaagat tgaagggcca 31021 gcctctgcag agagccttct tgctgtgtca tgccatggca gaagggcaaa gagagggcaa 31081 gagagagcaa aagcaaattc acagcatcaa tcccttttat aatcagcatt actctattaa 31141 tgagggcaag accctcatgg cctaatcacc tctaaaaggt cacacctctt aatactattg 31201 caatggtaat taagtttcta atacatactt tttgggagac attttcaaac tatagcacct 31261 accctatagc ccaacatttc tactcctagg agtatgccct agagaaattc tgcataaata 31321 tctaaagaga ggccattgtt gcattgttag gtactggaaa attggaatca attactatgt 31381 ctaccagcag cagaagatgg ctttttaaaa gttttggttt attcatgaaa tggaatattg 31441 cataaagtat gctccatctc accagatgaa aacatttttc actaggacta tttcaaaagt 31501 agtcttatca ctgggcttct ctattatgca taaaaatttt aagtgaacat gttctttgac 31561 ctagtactcc tacttttagg aatttgccca aaagggacaa ttatactact gggataaatc 31621 tttgaatcat aaagtaagtt gtaaatggta caagcagtat gtcttatttt tatttaaagc 31681 acattaacaa tattacacat atagtaaaaa ataaataaat aaaacatgtg aataataaac 31741 acccaattta gaacaagtgt tgacagtgga gagggaaaga gagagaaaga aggagaaatg 31801 gggagtggga gcgggtacac aaggaaattt tagttgcagc tccaaatttt tactttttac 31861 acaatgaagc gaatatggca aaataagatt tgttaaagtt gggcagcagg tacacagata 31921 ttctatcatt atcctttgaa tatttctgta gatttaagtt gtccattaaa aaaataaaat 31981 acacacataa tttttaagat tagttttttc tatttcctgg ccttcgcatg cactgttaac 32041 tttacctgga attctttatg cagtaattaa gagcaaaggt gtagagcaag actgcttgag 32101 cttggatccc agcactgagt tgatttaggg agaataactt aatctcttaa tcccaagaga 32161 aaatatgata taatagtttt gagctcataa agttttcata agcattaaat gtgacctata 32221 tatgtaaagc aatctaacag tgcctatagt atttataagt gtctgcatta ccaaattcat 32281 cattatcatg gcatgtcatg tcaccatcca ctacattacc atcactgtca ccatcatcat 32341 catcaccacc accatcatca ttaactccct ttgtctagtc aattcatatt tgttcttcgt 32401 attttagata cctgttaaaa tattttttca aagatgtcta ctctgattct tcagtacaaa 32461 tttgatttaa taagatccta tcattttgtc caaatactta taaaaatttg tagttctata 32521 tttaatgtgt tttgtttgtt taacatctct ctcctacatt gtgttaagtt ttttaaagag 32581 aaggtaaggg ttaaagagag acatagagag agaaagagag acagagagag agagagagcg 32641 gttctacagc aatacaggta tattagaaaa acctgcaaag gtggggacca gcttaatgcc 32701 agagcccccc actgcttata ggctggggta cttataggtc tgggggtact tataggcctg 32761 ggtgggtggg gtctgagcag tatggcttgc tgcccaagaa gatgttgata agacgttccc 32821 atgatgaggc agtttggtcc ttgcttccat agagtgtgat gcttcttgca ctttttccca 32881 gcagaatgtg gtagggatgt tccttcaggt gggcctttgc ctggcagggt atgataagga 32941 tgttcctgtg ccttggaatc aggtagttag acaggatgtt tctcacagcc tgaaccccca 33001 tggaatgttt cactttgacc agggtctgcg aaatagcagg gggcttacaa aatggtgtag 33061 tttggactaa caccttggaa cacaaaagtt tcttggggcc aaggctggcg tattagtctg 33121 ttttcatgct gctagtaaag acatacctga gactgggtaa tttataaaga gaaaagaggt 33181 ttaatggact cacaattcca catggctgga ggcctcacaa tcatgaggga ggcaaaggag 33241 gagcaaaggc acgtcttaca tggtggtagg caagagaacg tgtgcagggg aactgccctt 33301 tataaaacca tcagatcttg tgatacttat tcactatcaa aagaacagca cgggaaaaat 33361 ctgcctccat gattcaatta cctcccacca gattcctccc atgacatgtg gtaattatgg 33421 gaactacaat tcaagatgaa atttgggtgg ggacacagtc aaaccatatc agctgggtat 33481 gttttattca cctttttata cccattgtca tgtcttctgg acaaacaatg gatgtaaaat 33541 ggtatagact cctgagtact catttgttga atgacaaatc tatgaaccat ttgaccagta 33601 tgcagcagcc attaaaatta tgtttatgaa taatttacag catggaaaaa tttggggttg 33661 ctagtagaaa aacaaaaagg tacaaaagga tatatataat aagcctacaa tgccatataa 33721 acaatactaa cagcaaaaac aaacctataa attgggggaa gatggggcag atagaagtaa 33781 cctaaaatac taacatgttg ttttggggtc atgaaattat aaatgattat gcacccctta 33841 atttttactt tctatgtttg atttttctat ggtaaatgca tttttattga ggtggaattc 33901 acataacatg aaatgaaaaa tttagtggca tttattatat tcacaatatt gtacaaccac 33961 tagctctact tccaaaacat tttcatcact ccaaaataaa accttgtacc cattaagcag 34021 ttactcccca ttatttcctc tcttagctcc tagcaaccac caacctgctt tctgtctcta 34081 gggatttatt tattctgga.t attccataaa aatggaggca caatatgtac cttttatgtc 34141 tggcttcttt caccaagcat gtttttgagg ctaatccaca ttgcagcatg tatcagtact 34201 tcatttcttt ttatgaataa ctgtatacag accacaattt gttatccatt ttttggttta 34261 tggacatttg ggttgtttcc atctctcaac tattgtgaat agtgctgcta tgtatatttg 34321 tgtacaagaa tttggttacc tattttcaat tcttttatgt atatatctaa gatgaaattg 34381 cagggttata tgctaatcct atgtttagca ttttttttta ggaaccatta aactgttttc 34441 caaatctgat gccccatttt atattcctac tagcaatgta agcaagttcc aatttctcca 34501 tatcctcaac aacacttgtt attttctatt tttgttatag ccattctaat gagtgtaaag 34561 tgatatatca ttgtggtttt ctttgcattt tccttatgaa cattgatgtt gagtaccttt 34621 tcatgtactt tttggtcatt tatatatcat ctttggagaa atgcctcttc gtgtatgttt 34681 tgcccatttt aaaactagat tgtctttgtt gttgacatgc atgcattctt taaatattct 34741 gcatactagg cccttatcag atatatgatt tgcaaatgtt ttttctcatt ttactggctg 34801 tcttttcact ttattgataa tgtcctttga tgcccaaaag ttgtttattt tgatgaagca 34861 tatttatcaa tttatttctt ttattgctca tgcttttgat gtcacctcta agaatttata 34921 accaaatcag aggtaatgaa ggtttacccc tctattttct tctaagagtt ttatagtttt 34981 gactcattta cttaggtcgc tgattcattt ttagttaatt tttgcatatg atgtgaggaa 35041 gaggtccaac tttactcatt tgcatgtgga tattcagctg tgccagcacc atttgtgaag 35101 agtctatcat ctcctcattt aataatagta ttgacacctt tgttgaaagt caattgataa 35161 taaatgtatg agtttatttc tggaatctaa attctattcc attgatctac atgtctatcc 35221 ttgtatcagt atcacactat cttgattact gtagatttgt agtaagtttt gaaactagaa 35281 agtgtgagta ctgcaatatt cttctttttc ttttttaaag attgtcaggg cctcttgcaa WO 00/09525 PCT/US99/17712 EPI-109 859 35341 tttaataggg atatgaggat tgacttttct attctacaaa attaaaattt tgttagagat 35401 tgcattgaca ctgtaggzag ctttcagtaa cattgccatc tcaacaattt taagtattct 35461 aatacatgaa tatgagczzt ctttctcttt atttaggtct tctttaattt ctttcagcag 35521 tgttttgtag ttttggggta caagtctttc acctttaaat tttggtgaaa tttattccta 35581 ggtattgcat ttttttazgc tattgtaaat aaaattattt tctcaatttc ctgttggatg 35641 ttcattgcag gtgtatagaa actcaactga ttctttgtgt tgatcttatg ctgagaccag 35701 ctcagttggg gagaccctaa cctagaagca ctagaggaat taaagacaca aacacagaaa 35761 tatagaggtg taaagtggga aatcaggcgt ctcacagcct tcagagctga gagcttcaaa 35821 cagagattta cccacatatt tattaacagc aagccagtca ttagcattgt ttctatagat 35881 attagattaa ctaaaagtat cccttatggg aaacgaaggg aagggctgaa ataaagggat 35941 gggttgggct agttatctgc agcaggagca tgtccttaag tcatagatca ctcatgctat 36001 tgtttgtggt ttaagaatgc ctttaagcgg ttttctgccc tgtgtgggac aggtgttcct 36061 tgccctcatt ccggtaagcc cacaaccttc cagcgtgggc attatggcca tcatgaacat 36121 gtcacggtgc tgcagcggtt tttatggcca gttttggggc cagtttatgg ccagattttg 36181 gggggcctgt tcccaacaat cttatacctt gcaattttgc tgaatttgct tgttaacttt 36241 gatagttttt ttgaggatta tttgggattt tctacatatc atgtcatctg tgaataaaga 36301 tagttttgct tctttctttc tcatttggat gccttttatt tccttttctt gcctaatttc 36361 cctggctaga acttccagta tgatgttgaa taaccatggt gaaatgggca ttcttgtctt 36421 tttcctgatg ttagagagaa atttttcagt ctttaaccat tgagtataat gttagctgtg 36481 ggttttttac aaatatcttt tatcatgttg aggaagttcc ttcctactcc tacttcttgg 36541 agtgtttttg atataaaggg tatttaattt gtcaaatgct ttttctgtgt cagttgagat 36601 tatcatgtga gatttttttt ccttcattct attagtgttg atgttacatt ggttgatttt 36661 ttatgttgta ctacatttgc attctttata taaatttcac ttggtcatgg tgtataaccc 36721 ttttaatatg ccattggatt tagtttgcta gtattttgtt tagagttttt gcatctatat 36781 tcataagcaa tatcagtcca caggtttttt gtggtttatt tgtctggctt tgctataatg 36841 gtaatgctgt cttcttagaa tgaatgaggg agtgttttct cctctttcat tttttaaacg 36901 tttgagaagg agtgatatta atttttcttt aaatgtttgg tagaacttac cagtgaagcc 36961 gtctggttct taacattttt ctgtgttggg aggtttctga ttaccaattt gatctcttta 37021 atttttacag atcttttcag attttctatt tcttcttgag taacttttta gcaatttatg 37081 tattttagaa atttgttcat ttaatctagg ttatttaatt tattggtgtg cattttttca 37141 tagtattatc ttataatctt ttaatttttg taaagttgat aatgtcccca ccttacctga 37201 tcttagttat ttgtgtcttc tctgtattct ttttgtcttc ttcttctgtc ttagcatagc 37261 taaaggtttg tcaactttgt tgatctttta aagagtcaac ttttgctttc agcatgcatt 37321 actttttaaa tagaaatata tacacctaag ttgcattaca aaggagttgt cctccacaca 37381 cttattcttt cccaccatca gaggtttatg gtccccgcaa aagtcaccat cagttgggct 37441 caactccaat cagtcatggt aggtcagggt ccatctcatt gtctccatca ctcatgccca 37501 cccagggtaa gtctaatcat gttcaccaat cagaacctct gccacatcag ctctgtgggt 37561 ttcctctcat gccatctgta ccaacaatga gcacagtctg ggtttcctga tgttttctat 37621 agcatggtgc ccctccctgg gacacctcag aagccacaat gatattcatt aaacttcttc 37681 ctgcaagtac tccctctatt gctccttcta ctcaccaagc ttagtgtcag ggaatatgct 37741 ggtggggagt atgaatctta gcttctcact cccagactcg gctcccaacc tgctgttgcc 37801 aagtcttggg gacatctata aatgccttct aaatacctgt cttggcctat ccccagccac 37861 agattcctcc ctagagcagg ctacctctga ggcatctata ctgagatctt aatcacagag 37921 acatttaaaa catctaggct acaaaagaat tcctactata gggttcaaat gaatttcttt 37981 ccgtcacttg agacagcttt ttagcaagta catgtattaa agattctgat ttcccctttt 38041 ttctcctaca gtttgtttgg cctaaaggta tgacatctaa tctgctgcat ttacactcta 38101 agtcaaaatt accattttgt tcttttaatt tctatttcta atcatacatt cttgtctact 38161 cctggttcat ctggagacaa agttgaactt agaagatgga ggagaaattc ttatctgccc 38221 tctgctagtt gacacttcct ttccaagaat catttgcagt tgctgggctt tcttgctgtg 38281 actctatgcc ctgttgtgtt actttttcat ttgtgacaaa aacagtggta atagtttgct 38341 tcatttttat tatgaagact tgaccaggat aggtaggaac ataattactg ctttttctgt 38401 gggcatcata ttggtccaga tcatgtttaa ccagaattga agatgtaaaa tcctagaact 38461 cactaatcta ttttagtagg tcacaggaag catgcaaacc ataaaaaccg caatgaacca 38521 aaagcatctg tgttgacaag aggcaagaat ttctctattt tctaaaggca ctaactgaac 38581 aaatctattg cccattactt aggaaattgc taagggcatc gttaaagtac ttcaggctgt 38641 tgaaaaacct tttctgtctt cttgccccac caccaattct ctctagctat gctttctctc 38701 acatgttctt gccatccatg gagtggcaga gaggttctga gtacaactct aactttcagt 38761 ttcaatggcc taatccccaa ctcaactgct gaccttgagt gtaaaaataa acaagatctt 38821 aaacatctta gggccagcat tctgggtctt cttttgttat ttggggagca taaactattc 38881 tcatatcatt ggcttgcaga aaaattgagc ttctcctctt ccttgcccca tgtcaccttg 38941 aggtgaccac agccctgcct tctatgtaat cctgcttggt cagcaggcac atcagagctc 39001 agtggcttgt gacatacttt ccttcaagcc tgctcgaagg gccatactca tcattgagac 39061 tgggaacctt agaaaccatg aacccagtgc caatgggtag atacagaatt ctcaaactca 39121 tgaaaaaaca tcctttttaa ctctctccgt gtgcataaag aattctaaga tgtactgatc 39181 aagattccca attttctaac tatctattaa tatatggacg aggtaagaag aaagttgcaa 3924 1 gaaaaaaatt tgtttgactt gacggttgtg tggttatttg ccacactccc ccagatccac 39301 tctgagtccc aggatgctga ttttaggggc tacattgcct agactgtcca ttattccctc 39361 ttcccatctg gttcagtcac tgggaagcac tggtaggagg tcagagtggg agaaggaggt 39421 taggatactt tctgcccctg ctgtcctact gctttgctga acttctagca gtggctgagc 39481 catcaacctg cagctctcaa ttccagctgt ctgtagcact caagtggtat tgtttattct 39541 tttgatcctt ctagctgtta aggaagaaaa aaataatttt ttcctcaatg ctcataagtt 39601 cttggaatgg acccctgtaa caaaagacag attaacacga gaaaagttta ttaacgtaca 39661 tattttatac gtacatagga gctatccagg gaatgaataa ttcttaaaaa ggtgactttg 39721 aattccagct catatagcat cttcaacaaa gttcagtaac attttagaga tatgacaaga 39781 caaagaaaat gaactttgag cctctaggga cagtgacttg taggaaggca aaaggaataa WO 00/09525 PCTIUS99/17712 EPI-109 860 39841 atggaggtaa aggctggtta gtaatacttg ttaatgaaga ttcctctggt gccatctcca 39901 ggtccacaag gatttaaatt tgtcttcagt ggtgaacctt tgttcaccct ggcagaaggt 39961 gtggaggggg gtgcagatcc gttttgtctt tgtaagtcta tatcctgctt ttagacaaat 40021 aaagggaggg aaaagagctt tccttcatct gcttcttaat tgccttcagc tcaacaatcc 40081 ttatgcaaaa gaggtacatt ttagggtgtc aaattctggt ctcccacaaa gcatagggat 40141 gacagaccac ctcaccatcc ctgttgcttc ttttaagcct gctcacccct ccaaaaatat 40201 tttcattcta tactgtctct tcaaaatctc agcggagggt gccctctgtt atcctgccct 40261 ctgtgtcagt ataagccaaa ggtttgaatc ctggctctgc aactarctac ctctgtgcct 40321 ctccttgttt atgaaattac agggctggag acaaagatca caatgtgaag acaaaattgg 40381 agagcggtcc taatcagcca gagcaaaatt tctggctctt gctctzcccc atcctgggtt 40441 gaatcatagg aacaggtggc aagatgccag ggtcaggaga ttccagaagt ggcagcaagc 40501 tcagtgttac caggtcaggg atgacctgtc ttattattga aatctcagag atatgctcca 40561 attccggccc agagacacat tgagagacaa ctggggaact tgctatgttc ctgaacaggc 40621 aatgagctgt cttccaagaa aaaacctgag acccttcaag tctcaggtct tacttagcac 40681 atataccagg tcttacacag gacacatggt tacaactgac tgaaatctgg gctgggtgta 40741 ggagctcaca cctgtaatcc cagcccttca ggaggctgag gcaggcagat tgcctgagcc 40801 caggagttcg agaccagccc gggcaacatg acaaaacccc atctctacaa aaaatagtca 40861 ggcatggtgg catgcacctg tagtctcagc tacttgggag gctgaaatga gaggattgct 40921 tgaggttgag actgcagtga agcatgatca tgccaccgca ctccagccta ggcaacagag 40981 caagatcttg tcgcaaaaga aagcaaaaac acaacataac acaacaacaa caacaacaac 41041 aacaacagca aaaaagccaa cttcttgaaa tctggaaagg acacctggac tgccctgagc 41101 atttgattgt tgttggctct agcagtggat gcatccttca acctctggca ctctgcaggg 41161 ctcagactgt tctgttctgt ttgttacctg tggagtgcct gccagaccct gctctagctg 41221 ctttaggtcc atttaccctc atagaccccc agtcttgtta ttcatatttc atatttggga 41281 aatggaaact tagaaacttg ccaagtccac agcatgagat cctgcctccg gtgtctgctg 41341 gattccagaa agtgccaggg gccaacttag atgacaccat gttctctgca caatcttagg 41401 aatgctccta gtctgatgtc cccattgcaa aatttacatt atcttttaac aaaacgtctt 41461 tccaaggagg ggcatttaaa ataactgagg ttcttcttgc taaggacgtt cctgacacaa 41521 gagataattt agcatttcct tttcattaaa aagtttgaaa tcctgtaatt tgtgataatg 41581 tggatgaacc tagaggatgt taagtgaaat aagccacaca cagatagaca aataccacgt 41641 gatctcactc ttatgtggaa ttttttttta aataagttgc ttagccgggc atgatggcac 41701 acacctgtaa tcctagctac tcaggaggct gaggtgggag gatggcttga actcagaagg 41761 tggaggtagc agtgagctga gactgtgcca gtgcactccg gtctgggtga cagaatgaaa 41821 cccaatttaa aaaaaaaaaa aaagttgcta tcttagaaaa agacagtaga gcagtggtta 41881 ccagagactg gggaggaaag agaggaggtg agaatgggca gcagttgatc aacgggtaca 41941 aagttaccat gagataggag aaacaagtgc tggtgctctg ctccaagtag ggtgacggta 42001 gttaataatg aattctgtat atataaatag ctagaagaga gggttttcaa tatcattatt 42061 atttcaaaag aaatgataaa tgtttcagag gatggatatg taattaccct gatttgatca 42121 ttgcacaatg tatacatgta gcaaaacatc acattgtgtc ccataaatat atacaattat 42181 tatgtgaatt aaataaaaaa aaattttaaa gtcttatcta aatgaaattt ctaaccagat 42241 tctgaatcca tgataccact gaaaccagca cacatgatcg cagtaaaacc tcattatact 42301 tcctccacta tcaccaatac cctttattct ctggaacatg aaacattctg ttgtgctcat 42361 atcatgcaaa ttatcactag taggagagca gagagtggaa atgttccagg tataaagacc 42421 cacaagataa agaagctcag agtcgttaga aacaggagca gatgtacagg gtttgcctga 42481 ctcacactca aggttgcata agcaagattt caaaattaat cctattctgg agacctcaac 42541 ccaatgtaca atgttcctga ctggaaaaga agaactatat ttttctgatt ttttttttca 42601 aatctttacc attagttgcc ctgtatctcc gccttcactt tctgcaggaa actttatttc 42661 ctacttctgc atgccaagtt tctacctcta gatctgtttg gttcagttgc tgagaagcct 42721 gacataccag gactgcctga gacaagccac aagctggtga gttgtaggca ttttttccat 42781 tactttctga ttcataggct caacgcacct caaagctgga aatgccgggt ctgggtacac 42841 cctggggaac tgcaaagcct gcacacttgg gggaaatgat caagatgaga ggcaggggtg 42901 gggatggcat gtgcaccagg agatgttaga gaaaccctga ggaagagcag cgtgcagcag 42961 gtgatggggg agagtgggca gcaagcgagg ccaggacagc cactctgctc agtcaccagt 43021 ccacacaccc aggggctcac tctgcccctc tgagcaccca aggacgttaa agagctggaa 43081 ctgttagtct aaatatagga ccatccaagc tctgaaccaa aatgtgtccc ttgcctcaac 43141 tcaggagatc cacagaggca gaagtaagga atttattttc tgaaagatag atttctatca 43201 gttctgggtg acatgttctg acacttgaaa tgacacctag gacagcacat ttcaggcatc 43261 ttgctcattg ttcactgtag tagaagctac atgctagcca gttgtaaaaa tgaaattaag 43321 taatgtgtgc acagcattta acatagcatc tgagcttcag gagcactcaa ttaatgacca 43381 cagttgtgat tctttaggca gatgcatttt tttccaactt tgatcagagg tcttatttag 43441 cttctccaga tttcaagaat ctggctcagt gatatgaaat acaagacttg tgaaaagtgt 43501 caattgcaag agaaatggaa ggataaagta tacaggtggg tggaaaagaa attcacagtc 43561 actgccagaa aaaaaattct tgagaatcaa gtcctgatga tgttagggct tatagttctt 43621 attataaaga gttttatgta ctcattcagt gaacatttat tggtgcctcc tttagccagg 43681 tactatcata agagctgaaa ataaaagcat aatccagtcc ttgatcttga ggaacatgct 43741 gtgtgtagca gataacataa taagtgctta tctagatgca tgcagtgtta tgtgataaga 43801 gtaatatgac agaggataca gattaggctt cacagagaag ggggatttga gcaggaggta 43861 ttgaagggtg aatagaagct caccaatcat tttgggcaga ggggcaagga cctgcaaaac 43921 cactgaagca tgaaggaaat ggtgagttta gggaaaatga agagaagatg gctgtgactg 43981 aagcacagga tttgggattg gagaagggac tggaggtgag gctgagaaga ggcaaactca 44041 gaaaagatgt tgtgctgggc agtctggaca ttatctttga agcccaccac atataagtca 44101 tagggctact ggaggtttta agctaaaagt gactattcaa tttcaactta agagaagata 44161 ggttgagagg gaacatggct tgagatgagc catgagcaaa ggaaaaacta caacaaagcc 44221 aggagtgagg agtgtgtgaa gcaagaaagt gacagttgaa agcagtgcag aggggatgaa 44281 tctgagaggc atctatgagg tggaactcaa atgacatgat aataatacag ggcatttctc WO 00/09525 PCT/US99/17712 EPI-109 861 44341 tgtgtcagat actgtcctaa gtccttactc cattgatctt cacagcaact cagcatagtt 44401 aatattttat gcataaagaa atcggcactt gaaggagtaa ttggccccag attacactgc 44461 ctataaggat tcaaatccag gtttgtttgg ctccaaaaac tggctcctaa ttttcagaag 44521 gagaagcgac ccagggcaat gcccaatttt gcttcttagg caatggagga atccacaatc 44581 ggaaggagtt ttcagcagtg ccccatttgg ggtgggttga atttgaggtc cctgcatgat 44641 acccactttg ctcacttcag tgcctaaaac tgagtatggt tcatagtagg tgttcaataa 44701 gtgttgatgc agtgaataca tgcatgggga gatatgcatc aggcaatggg aaattcaact 44761 ctaaggctra ggggaaagct ggagcttgaa gacagagctt tagaaaacag tagcatagaa 44821 gggagtagga accatgagtt tagacaatac aattcaggaa gaactttgta gcaaggataa 44881 agaggcaaaa aattaaagag gtgagagcta agtgtggtgc ctggggaatc ttaaggtgtg 44941 ggcacgggga ggagatgcca gcaaagaaca tgaataaaaa gcggtagcac agcccctccc 45001 atctggaagc caaaaagaat tgtaaatgga ggaagttagc agaaggatca aatacttgaa 45061 gagggtggaa ttggaataaa accagggcat ttgaaaaatt gggttgtcac tgcaatctta 45121 acaagagaag ttttggcagg atgatggagg cagaaagctg agagaatcat cagttagaac 45181 gtttttgact tcagagaaca gaaaatgcag ttcataatgg ctttaaaaca ggggcttgtt 45241 tttctcccag caatttgaga ggccaaggcg ggtgcatcag gaggtcaaga gaccgagacc 45301 atcctggcca acatggtgaa tccccatctc tactaaaaat acaaaaatta gcggggcatg 45361 gtggtgcacg cctatagtcc catctactca ggaggctgag gcaggagaat cacttgaacc 45421 caggaggtgg aggttgcagt gagctgagat catggccact gcactatagc ctggagacac 45481 agcgagactc cgtctccaaa aaaaaaaaaa aagaaggcag aaggtgaata gttcaagggt 45541 gggtttagga ctcagtgata ataggattct gcctggcttc tcatggttct ctaggtcttc 45601 cattcatggc accatgccct cactaggcat gctgccagag caggaggggc aggtggaggg 45661 ttctcttgtg tctgtcttat cagggaagaa gagctttctc agaagccccc agcagactcc 45721 cttttcatat tatggtccag caatgagtca cagacctatg caccacctgc aaaggagcca 45781 gagaaaacaa acgcccagcg cttttagcct gaaaatgaga atctggtttg ctggggaaga 45841 taaagggtgt cggaaaatgg ctgttgggta aatcattgat gtctgccact aggaatgaaa 45901 ggcaaatcag gaactggcac acatgctttc agggagatgg ctgcaaggga gagggcaaag 45961 actgggaagt tgcttatgtg gtgccagact atttggaaga tcatggattg cggtgtttgt 46021 gttgtgtggt catcattttg ttctttgttt acagaacaga gaaagtggat tgaacaagga 46081 cgcatttccc cagtacatcc acaacatgct gtccacatct cgttctcggt ttatcagaaa 46141 taccaacgag agcggtgaag aagtcaccac cttttttgat tatgattacg gtgctccctg 46201 tcataaattt gacgtgaagc aaattggggc ccaactcctg cctccgctct actcgctggt 46261 gttcatcttt ggttttgtgg gcaacatgct ggtcgtcctc atcttaataa actgcaaaaa 46321 gctgaagtgc ttgactgaca tttacctgct caacctggcc atctctgatc tgctttttct 46381 tattactctc ccattgtggg ctcactctgc tgcaaatgag tgggtctttg ggaatgcaat 46441 gtgcaaatta ttcacagggc tgtatcacat cggttatttt ggcggaatct tcttcatcat 46501 cctcctgaca atcgatagat acctggctat tgtccatgct gtgtttgctt taaaagccag 46561 gacggtcacc tttggggtgg tgacaagtgt gatcacctgg ttggtggctg tgtttgcttc 46621 tgtcccagga atcatcttta ctaaatgcca gaaagaagat tctgtttatg tctgtggccc 46681 ttattttcca cgaggatgga ataatttcca cacaataatg aggaacattt tggggctggt 46741 cctgccgctg ctcatcatgg tcatctgcta ctcgggaatc ctgaaaaccc tgcttcggtg 46801 tcgaaacgag aagaagaggc atagggcagt gagagtcatc ttcaccatca tgattgttta 46861 ctttctcttc tggactccct ataacattgt cattctcctg aacaccttcc aggaattctt 46921 cggcctgagt aactgtgaaa gcaccagtca actggaccaa gccacgcagg tgacagagac 46981 tcttgggatg actcactgct gcatcaatcc catcatctat gccttcgttg gggagaagtt 47041 cagaaggtat ctctcggtgt tcttccgaaa gcacatcacc aagcgcttct gcaaacaatg 47101 tccagttttc tacagggaga cagtggatgg agtgacttca acaaacacgc cttccactgg 47161 ggagcaggaa gtctcggctg gtttataaaa cgaggagcag tttgattgtt gtttataaag 47221 ggagataaca atctgtatat aacaacaaac ttcaagggtt tgttgaacaa tagaaacctg 47281 taaagcaggt gcccaggaac ctcagggctg tgtgtactaa tacagactat gtcacccaat 47341 gcatatccaa catgtgctca gggaataatc cagaaaaact gtgggtagag actttgactc 47401 tccagaaagc tcatctcagc tcctgaaaaa tgcctcatta ccttgtgcta atcctctttt 47461 tctagtcttc ataatttctt cactcaatct ctgattctgt caatgtcttg aaatcaaggg 47521 ccagctggag gtgaagaaga gaatgtgaca ggcacagatg aatgggagtg agggatagtg 47581 gggtcagggc tgagaggaga aggagggaga catgagcatg gctgagcctg gacaaagaca 47641 aaggtgagca aagggctcac gcattcagcc aggagatgat actggtcctt agccccatct 47701 gccacgtgta tttaaccttg aagggttcac caggtcaggg agagtttggg aactgcaata 47761 acctgggagt tttggtggag tccgatgatt ctcttttgca taagtgcatg acatattttt 47821 gctttattac agtttatcta tggcacccat gcaccttaca tttgaaatct atgaaatatc 47881 atgctccatt gttcagatgc ttcttaggcc acatccccct gtctaaaaat tcagaaaatt 47941 tttgtttata aaagatgcat tatctatgat atgctaatat atgtatatgc aatatatata 48001 ggctcttgct tgatctctcc aggaggtagt gattatgaga agggggtgga gaatgatgag 48061 ttccttcacc aggagcaaag gacggggatc gtgtggaacc actgcagaac tatttccgga 48121 atcaactaag tggagagagc caggaaggct gcatcagaac ccagtaaagc ttcttgtctg 48181 gatctgagct ggtttgtttt gtgcttgctt ttccctgcct tgccactccc ctcactcttc 48241 tcttttcccc acagcctttt tcacatagct cttggctgta ggattgcccc actccaaaaa 48301 ccagtgtgtg gaggtccagg agtgagacca ggaaagaatg tgaaagtgac tacacaagga 48361 ctcctcgatg gtcgtggaaa aggaaagtca attggcagag cccctgaagc cagtcttcag 48421 gacaaagaag gagcctagag acagaaatga cagatctctg ctttggaaat cacacgtctg 48481 gcttcacaga tgtgtgattc acagtgtgaa tcttggtgtc tacgttacca ggcaggaagg 48541 ctgagaggag agagactcca gctgggttgg aaaacagtat tttccaaact accttccagt 48601 tcctcatttt tgaatacagg catagagttc agactttttt taaatagtaa aaataaaatt 48661 aaagctgaaa actgcaactt gtaaatgtgg taaagagtta gtttgagtta ctatcatgtc 48721 aaacgtgaaa atgctgtatt agtcacagag ataattctag ctttgagctt aagaattttg 48781 agcaggtggt atgtttggga gactgctgag tcaacccaat agttgttgat tggcaggagt WO 00/09525 PCT/US99/17712 EPI-109 862 48841 tggaagtgtg tgatctatgg gcacattagc ctatgtgcat gcagcatcta agtaatgatg 48901 tcgtttgaat cacagtatac gctccatcgc tgtcatctca gctggatctc cattctctca 48961 ggcttgctgc caaaagcctt ttgtgttttg ttttgtatca ttatgaagtc atgcgtttaa 49021 tcacattcga gtgtttcagt gcttcgcaga tgtccttgat gctcatattg ttccctattt 49081 tgccagtggg aactcctaaa tcaaattggc ttctaatcaa agcttttaaa ccctattggt 49141 aaagaatgga aggtggagaa gctccctgaa gtaagcaaag actttcctct tagtcgagcc 49201 aagttaagaa tgttcttatg ttgcccagtg tgtttctgat ctgatgcaag caagaaacac 49261 tgggcttcta gaaccaggca acttgggaac tagactccca agctggacta tggctctact 49321 ttcaggccac atggctaaag aaggtttcag aaagaagtgg ggacagagca gaactttcac 49381 cttcatatat ttgtatgatc ctaatgaatg cataaaatgt taagttgatg gtgatgaaat 49441 gtaaatactg tttttaacaa ctatgatttg gaaaataaat caatgctata actatgttga 49501 taaaagattt aaaaacaact ggctgttttt ttacactgtg gtgtggaaga ttgtgttgtg 49561 ttcacaactt ttcacttctt cccctgtgtg attacacaca cctgcccttg tggtgtgact 49621 tgcagtgcgc cctacaggcc acacaacccc atgccctcca ccactggctc tgctgctgga 49681 atgtgagcag aagtgacatc tgcctcatcc aagcagagcc tcttgctcag ccacaggaag 49741 gcccattcca gatcacaccc gtcagcccgt gcgccctggt gaatgagaag acacagggag 49801 ctgcagccac atataacatg agcaagaagt ctgtgtttgc tgtgataagc cactgagttt 49861 taggggttgt ttgttaagaa gcacaaaaac cgattaagac atgtggtata tagtgacttc 49921 atatatagaa tctggaaaac tatccattta ttttcaatca tggaattcaa tatgacaagc 49981 atcccggagg gtctacctat gccagactgg gttggaaaca gaaagacaga tgttaatgcc 50041 agtgtccttt acacctccaa gtccagggcc agctgtggag tgggaggggt agagaaggtc 50101 ctgtgcacag tcacagtgcg ctgtgcagag caggaacaga ggcatctgtg aaaagtgctg 50161 agagcctgga ggacagagtg actaatgcaa tgacagtctt gcatcatagg aataacagcc 50221 acagcaggat tttattgctg ccaaagaaac tgccatttaa aaattgccag ccatccggga 50281 ggctgaggca ggagaatggc atgaatccag gaggcggagc ttgcagtgag ccgagatcgg 50341 gccactgcac tccagcctgg gcaacagagc cagactccat ctcaaaaaaa aaaaaaaatg 50401 ccagccatct ctctttctaa agtggaatcc tcaagtctcg tttattctgg ggacatttga 50461 gtaggctgtt cgagttaagc aggtggaagt tgatgatccc tcatcatcat tctgagggat 50521 gagtgtctga agactttttg gtaaggaagg gtcttggcat agcccacccc atgccacctc 50581 ccttgatctg tgatatcccc agcagctggg gaggttggag cattttgcaa agaggccccg 50641 aagcctccag aaagtaaacc ttcaagagcc catccttcct tcctcttttg tttttgctca 50701 ttatgaaaac ttccctgaca aattgaaaag gcttcaggtg agattagccc acaggaaaaa 50761 ccaccaaggg ccacccagag gggccacact gtgacagaag gagtatgggc tggtgagctg 50821 acctctggaa gacagtgcat gaattgagga gaagagattg gttccaggca tgggaggaat 50881 gaggctggaa atttcttcag acattgccac ttcggcactc tgtgtgtgtg tgtgtgtgtg 50941 tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtaaacaga gtcctgtaat gcaaggtccg 51001 gccttggcag ccccagcctg gagccacagt gagatgtgag ctgagggtta tgctgggaaa 51061 aacctctccc tcccagcacc tgaaaggctc tgcaggccca gcagctcagc aagcaagggt 51121 aagggcatgg actaacatct tatttcatac tatcccttat aacacatcct aatgtaatca 51181 gctcacaata tgaaattatt tcatttctct ccagtcattg tttcaatggg gccttagggt 51241 tgactggatt ctggaggtcc ctgcctagag gagggggtgc attctgtccc tatgtcccct 51301 cctgctccat cctccacagc acgtgcctag tggtctacct tgtggggaat tcttgtacct 51361 ccctcttcta ggcatggact agcattgaga agtgggagag gagtgttagg aaaaagggca 51421 aatatagaca taccttgtct tattgtgctt tacagatatt gtttttgttg ttgttgttgt 51481 tgtttacaaa ttgaaggttt gtggcaaccc tgcctcgagc aagtctattg gtgctgtttt 51541 tccaacagca tgtgcttgtt ttacatctct gtgtcacatt ttggtaattc tcccaatatt 51601 tcaaactttg tcattatttc tatatctgtt atggtaatct gtgatcagtg atctttgatg 51661 tcactattgt agttgttttg gggcaccatg aagtgcaccc atgtaagatg gcaaacaatc 51721 aataaatgtt gtgtgtgttc tgactgctcc atggactgcc tgttcctgag acacaataat 51781 gtatatataa caattatata tatatatatt tataacaatt atatatatat atattttttt 51841 tttttttttg aggcagagtc gcactctgat tgcccaggct ggagtgcaat gatgtgattt 51901 cagctcactg caacctctgc ctccccaggc tcaggtgatt ctcccacttc agcctcccaa 51961 gctgggacta caggtgtgca ccatcacacc cggctaattt tttttttgta tttttaggag 52021 agacagggtt ttgccatgtt gcccaggctg gccttaaact cctagactca aacaatccac 52081 ctgcctcagc ttcccaaagg gctgggatta caggcatgag ccactgtgcc cagcccaaga 52141 cacaataata ttgaaattaa gccaattaat aaccctacaa tggcctctaa gtgttcaagt 52201 gaagggaaaa gtcccacgtc tctcacttta aatcaaaatc tagaaatgat taagcttagt 52261 aaggaggaca tattgaaagt caaggccaaa agctcacctc tgcaccagtt agccaaattg 52321 cgacttcaca ggaaaagttc ttgaaggata tttaagctct actccaggga acatgcaaat 52381 gaagagaaaa caaagcagcc atattgctaa tatggagaaa gtttgagtgg tctggagaaa 52441 agatccaacc agccacaaca tttccttaag tcaaagccta atccagagca agactctaac 52501 tctcttcaat gctatgaagg cggagagagg tgaggaagct gcagaagaaa agtttgaagc 52561 tagcggaggt tggtttgtga ggtttaatga aagacaacat ctccataaca taaaaatgca 52621 agatgaagca gcaagtgcaa agggagaagc tgtggcaagt tatccagaaa atctagataa 52681 gataattgat gaaagtgtct acacgaaaca acagattttc agtgtagaca aaacagtctt 52741 atgttggaag aagatgccat ccaggacttt cacagctaga gaggagatgt caaggcaagc 52801 tgcaaagctc cacaggacag gctgactctc tttttagagg tgaatgcagc tgatgacttt 52861 aagttgaagt aaatgttcat ttactatttt gtaaatcctg gtgtcattaa gaattatgcg 52921 aaatctactc tatctgtgct ccataaatgg aacaataaag cctggatgac aacacatctg 52981 tttacagcat ggtttactga atatttcaag cccactattg agaactattg ctcagaaaaa 53041 aagattcctt tcaaaatatt actgctctgc accatgtcga tcaagagctg tgttggagat 53101 gtacgagaat attcatgttg ttttcatccc tgctaacaca aacatccatt ctgcagtcca 53161 tggaccaaga ctttcaagtc ttattaagaa atatatttca taaggctatt aagaaatagc 53221 tatatatata tatatatata gccttatata gtttatatag ctaccattga tagtgattcc 53281 attgatggat ctgagcaaag caaattgaaa agcttctgga aagtagtcat tattctagat WO 00/09525 PCT/US99/17712 EPI-109 863 53341 gccattagga acatttgtaa ttcatgggag gaggtcaaaa taccaacatt aacaggagtg 53401 tgaaagacat tgattccaac ccccatagat gactttcagg ggttcacgtc ttcagtggag 53461 gaagttgctg tagatgtggt ggaaacagca agagaactag aactagaagt ggagcctgaa 53521 gttgtgactg aattgccgca ctctcatgat caaacttgaa cagatgaaga gttgcttctt 53581 acatatgagc agtgaaagtg gtctcttgag atggaatctc ctcctggtga agatgctgtg 53641 aacacggtta aaatgacaac aatcgattta gaatattaca taaatttagt taataaagca 53701 gtggcagggt ttgagaggat tgactccaat tttgaaagaa gtgggtaaaa tgctatcaaa 53761 tagcatcaca tggtatggag aaatcttttg tgaagggaag agtcgaccaa ggtggcaaat 53821 tgcattgtca tcttatttta agaaattgcc acagccaccc ccagctttag caaccaccac 53881 cctgatcagt aagcagccat caacatcaaa acaagaccgc catcctcttc agcaaaaaca 53941 ctatgacttg ctgaaggctc agatgatggt tagcattttt agcaatacaa tatttttaat 54001 taaggtatgc acattggttt ttctgacata atactattgc atacttaata gactacagta 54061 taggataaac acaactttta tatgcactgg gaaaccaaaa aggttatttt tgagatattt 54121 gctttactgt ggtggtctga agctgaactc acaatctcac caaggtgtgc ctgaacctct 54181 ttagctaact ggccactgcc acagtccact ctgtgttggt caagatgccc cagagtggca 54241 ggcacactgt gtggtcacat ccaagggcct agatatggtg ggggctccaa atggatctag 54301 atatgtgaga tctctctttg atttgacttc ttccaaccca ccattttctg ggtgctgggc 54361 tcatctcacc cagaaagtag gacccaatgt gacagttcct gcccagttcc ctcctgtggt 54421 agccacttga cccaggggca ctcttgatcc ttgcagcctc acttacacac cctatctcta 54481 cccctattaa ctctctccaa tccccactcc ccctgctcag cttgtctgct gcccagtggg 54541 ggccccaccc atgctggcct ctccttttgc aagtccccat tcctcatatg gtttcttcag 54601 agcccctttc tttggctttg aggagagatg ccctcactcg cttccccacc aatcctgccc 54661 acttctacaa tccattcatt atcctaattg cctccgtata cagactggag tgagaggagt 54721 tgatgtgatg ggtgtggata cagggctggt gctgtcatct tctagtaagc cctgggagag 54781 gtgtctgagc ccaggtgtca gtggttttct ttggaactgt gagtgcataa cacttctttg 54841 ccttcagcct taggccatag ttgctagttc tgggacaacc agaaaagccc tacataatct 54901 cgtgttatgt gcagagctga gtatagagct ccaggtatga tctgactcac ttaagatcac 54961 agtgagtcta ttgtattgtt gaactgttag cttagacatc tgttactgta cctacatggc 55021 actagcctca cgcctagaca ccgatctgaa agaaatcccc taaatgcata gagaagactt 55081 ctcagctgag ctaaggggct cccaccaggt ttgagcctat ctaatgaatc catgaggtag 55141 acagcctgca catgtccact tggtttgatg aattgcacaa atccctatgg gggatgtggt 55201 tcatgggctg ggaagtgggt taccctggga aaggtctaca ggacagaggc agggatggag 55261 acaacagcat ggtgagttcc caacccaccc acgatgatag gtgtctgagg cagaaggtaa 55321 agaggctgtc acctggtggg tgtcataaga ctcaagtgtc attgttgagg cacatgggta 55381 acaaagcgtg gcactggatg ggggtagatt cttcctattt ctgtgaggat cagggggact 55441 ccctggctct cctgctaaag gtggctctag ggacaggaag agtgtacttc ttgacaggga 55501 tgtcagagca ctgatggtga caatcagtgt gacactgctc acatgactga acaaccgaga 55561 agagcccgac tgtctactga acaacgggaa gagcccgact gtcaatgacg gagctctgtt 55621 aaatatagtt aaggctattt tgttgaatga atgaagccag acaggaaaga ggacagtatc 55681 tttaatccat ttatagaagt taaagacagg cttatttaat ctctatgaag acagagtggc 55741 ccttacctct gggtggagca aaaggcacct tctgaagtga tagggatgtt ccttatcatc 55801 ttgatccgga gtggtagtta catgcatgta tgcatatcaa aactcaccaa gctgtaccac 55861 taagtgtgtt cttcctcaat aaaaataata aagaactaca cttataaaga attttttaat 55921 aatataggaa aatgtctac'a ctataatctt tagctaaaaa aaaaaaaaaa gaagccgcct 55981 acagaatggt atatgcatga gaacaattaa tcgaaaagtg catgggaaaa gtcaggattg 56041 aaacatcatg ttttaaaaga cattgttttg atactgtgag aatgtaccta agtttttcct 56101 tttttctgtt tttcccaatt ttatacaatg agcatgtgtt ggttttataa ttagacattt 56161 tgtttgtttg gtttggtttt gagacacagc ttgctgtcac ccaggttgga gtgcaatggc 56221 ccaatcttgg ttcactgcaa cctccatctc ctgggttcaa gagattctcc cacttcagcc 56281 tcctgagtag ctgggactat aggggcgcac caccacatcc agctaatttt gtgtattttt 56341 agtagagatg gggtttcacc atgctggcca ggttggtctc aaactcctga cctcaagtta 56401 tccactcgcc ttggcttccc aaagtgctgg gattataggc atgagccacc gcacttggcc 56461 tagacatttg tttttaaaaa taaaagattc atttgctctt tttacagccc gtctcactgt 56521 tgactgatat tgaccaggag tcaactcagg ccccagggat tttcacaaca gctgctgtat 56581 ggcagggttt ctgctcactg tgctcatgta gttggccctt gcacccaaag tgaataatta 56641 acattctccc catcctgttg acgatgctct gaaaatatgg tccagaaatg gtgtgagcaa 56701 ggagacagca aagcaatgct tggaacatag gtgcagtgac tagacatggg gcagctgttt 56761 aaagacaaaa aggccccaaa aaggagggat ggcacgaaac accctccaat atgggcatgg 56821 agtctagagt gacaaagtga tcaaaagttc atttcctatg gggtgtccga atgtacttaa 56881 taataaaaag agaacaagag ccatgcaaac tgagagggac aaagtagaaa gagtagcaga 56941 caccaagcaa ctaagtcaca gcatgataag ctgctagctt gttgtcatta ttgtatccag 57001 aacaacattt catttaaatg ctgaagaatt tcccatgggt ccccactttc ttgtgaatcc 57061 ttgggctgaa cccccctgtc ctgagtggtt actagaacac acctctggac cagaaacaca 57121 aaagtggagt aacacacact gcaaagctgt gcttccttgt ttcagcctgt gaatcctcac 57181 cttgtttccc atctagccta tatttttcaa actaacttgg ccatagaatc atgtagtatt 57241 tagggtggaa gctgccccag gtctagcacg tcatttaaca gatgaggaaa tggaagcttg 57301 ggcagtggaa gtatcttgcc gaggtcacac agcaagtcag cagcacagcg tgtgtgactc 57361 cgagcctgct ccgctagccc acattgccct ctgggggtga gtatgtcttc acatcctcca 57421 ataccctaat gacagacaaa cagaacatgg caaagcctca gctctgcatg gtgaaagtaa 57481 gaaccagcaa ttgccacaaa cagaaataca gtgttggtcc ggcagcctcc gggggttctg 57541 cacaagtgga ttaccagtga atacaaggct atctatcttt cgaaaaacca acgttgtatt 57601 tatgctattt tctataaaat tttatattaa tttatttgtt acctattttt gaactctttc 57661 aaaagcacac tttatatttc cctgcttaaa cagtcccccg agggtgggtg cccaaaaggc 57721 tctacacttg ttatcattcc ctctccacca caggcatatt gagtaagttt gtatttgggt 57781 ttttttaaaa cctccactct acagttaaga aaactaaggc acagagcttc aataatttgg WO 00/09525 PCTIUS99/17712 EPI-109 864 57841 tcagagccaa gtagcagtaa tgaagctgga ggttaaaccc agcagcatga ctgcagttct 57901 taatcaatgc cttttgaatt gcacatatgg gatgaactag aacattttct cgatgattcg 57961 ctgtccttgt tatgattatg ttactgagct ctgttgtagc acagacatat gtccctatat 58021 ggggcggggt tgggggtgtc ttgatcgctg ggctatttct atactgttct ggcttttccc 58081 aagcagtcat ttctttctat tctccaagca ccagcaatta gctttacctt ttcagcttct 58141 agtttgctga aactaatctg ctatagacag agactccggt gaaccaattt tattaggatt 58201 tgatcaaata aactctctct gacaaaggac tgctgaaaga gtaactaaga gtttgatgtt 58261 tactgagtgc atagtatgtg ctagatgctg gccgtggatg cctcatagaa tcctcccaac 58321 aactcatgaa atgactactg tcattcagcc caatacccag acgagaaagc tgagggtaag 58381 acaggtttca agcttggcag tctgactaca gaggccactg gcttagcccc tgggttagtc 58441 tgcctctgta ggattggggg cacgtaattt tgctgtttgg ggtctcattt gccttcttag 58501 agatcacaag ccaaagcttt ttattctaga gccaaggtca cggaagccca gagggcatct 58561 tgtggctcgg gagtagctct ctgctgtctt ctcagctctg ctgacaatac ttgagatttt 58621 cagatgtcac caaccaccaa gagagcttga tatgactgta tatagtatag tcataaagaa 58681 cctgaacttg accatatact tatgtcatgt ggaaaatttc tcatagcttc agatagatta 58741 tatctggagt gaagaatcct gccacctatg tatctggcat agtgtgagtc ctcataaatg 58801 cttactggtt tgaagggcaa caaaatagtg aacagagtga aaatccccac taagatcctg 58861 ggtccagaaa aagatgggaa acctgtttag ctcacccgtg agcccatagt taaaactctt 58921 tagacaacag gttttttccg tttacagaga acaataatat tgggtggtga gcatctgtgt 58981 gggggttggg gtgggatagg ggatacgggg agagtggaga aaaagggggc acagggttaa 59041 tgtgaagtcc aggatccccc tctacattta aagttggttt aagttggctt taattaatag 59101 caactcttaa gataatcaga attttcttaa ccttttagcc ttactgttga aaagccctgt 59161 gatcttgtac aaatcatttg cttcttggat agtaatttct tttactaaaa tgtgggcttt 59221 tgactagatg aatgtaaatg ttcttctagc tctgatatcc tttattcttt atattttcta 59281 acagattctg tgtagtggga tgagcagaga acaaaaacaa aataatccag tgagaaaagc 59341 ccgtaaataa actttcagac cagagatcta ttctctagct tattttaagc tcaacttaaa 59401 aggaagaact gttctctgat tcttttcgcc ttcaatacac ttaatgattt aactccaccc 59461 tccttcaaaa gaaacagcat ttcctacttt tatactgtct atatgattga tttgcacagc 59521 tcatctggcc agaagagctg agacatccgt tcccctacaa gaaactctcc ccggtaagta 59581 acctctcagc tgcttggcct gttagttagc ttctgagatg agtaaaagac tttacaggaa 59641 acccatagaa gacatttggc aaacaccaag tgctcataca attatcttaa aatataatct 59701 ttaagataag gaaagggtca cagtttggaa tgagtttcag acggttataa catcaaagat 59761 acaaaacatg attgtgagtg aaagacttta aagggagcaa tagtatttta ataactaaca 59821 atccttacct ctcaaaagaa agatttgcag agagatgagt cttagctgaa atcttgaaat 59881 cttatcttct gctaaggaga actaaaccct ctccagtgag atgccttctg aatatgtgcc 59941 cacaagaagt tgtgtctaag tctggttctc ttttttcttt ttcctccaga caagagggaa 60001 gcctaaaaat ggtcaaaatt aatattaaat tacaaacgcc aaataaaatt ttcctctaat 60061 atatcagttt catggcacag ttagtatata attctttatg gttcaaaatt aaaaatgagc 60121 ttttctaggg gcttctctca gctgcctagt ctaaggtgca gggagtttga gactcacagg 60181 gtttaataag agaaaattct cagctagagc agctgaactt aaatagacta ggcaagacag 60241 ctggttataa gactaaacta cccagaatgc atgacattca tctgtggtgg cagacgaaac 60301 attttttatt atattatttc ttgggtatgt atgacaactc ttaattgtgg caactcaaac 60361 tacaaacaca aacttcacag aaaatgtgag gattttacaa ttggctgttg tcatctatga 60421 ccttccctgg gacttgggca cccggccatt tcactctgac tacatcatgt caccaaacat 60481 ctgatggtct tgccttttaa ttctcttttt gaggactgag agggagggta gcatggtagt 60541 taagagtgca ggcttcccgc attcaaaatc ggttgcttac tagctgtgtg gctttgagca 60601 agttactcac cctctctgtg cttcaaggtc cttgtctgca aaatgtgaaa aatatttcct 60661 gcctcataag gttgccctaa ggattaaatg aatgaatggg tatgatgctt agaacagtga 60721 ttggcatcca gtatgtgccc tcgaggcctc ttaattatta ctggcttgct catagtgcat 60781 gttctttgtg ggctaactct agcgtcaata aaaatgttaa gactgagttg cagctgggca 60841 tggtggctca tgcctgtaat cccagcattc taggaggctg aggcaggagg atcgcttgag 60901 cccaggagtt cgagaccagc ctgggcaaca tagtgtgatc ttgtatctat aaaaataaac 60961 aaaattagct tggtgtggtg gcgcctgtag tccccagcca cttggagggg tgaggtgaga 61021 ggattgcttg agcccgggat gatccaggct gcagtgagcc atgatcgtgc cactgcactc 61081 cagcctgggc gacagagtga gaccctgtct cacaacaaca acagcaacaa aaaggctgag 61141 ctgcaccatg cttgacccag tttcttaaaa ttgttgtcaa agcttcattc actccatggt 61201 gctatagagc acaagatttt atttggtgag atggtgcttt catgaattcc cccaacagag 61261 ccaagctctc catctagtgg acagggaagc tagcagcaaa ccttcccttc actacaaaac 61321 ttcattgctt ggccaaaaag agagttaatt caatgtagac atctatgtag gcaattaaaa 61381 acctattgat gtataaaaca gtttgcattc atggagggca actaaataca ttctaggact 61441 ttataaaaga tcacttttta tttatgcaca gggtggaaca agatggatta tcaagtgtca 61501 agtccaatct atgacatcaa ttattataca tcggagccct gccaaaaaat caatgtgaag 61561 caaatcgcag cccgcctcct gcctccgctc tactcactgg tgttcatctt tggttttgtg 61621 ggcaacatgc tggtcatcct catcctgata aactgcaaaa ggctgaagag catgactgac 61681 atctacctgc tcaacctggc catctctgac ctgtttttcc ttcttactgt ccccttctgg 61741 gctcactatg ctgccgccca gtgggacttt ggaaatacaa tgtgtcaact cttgacaggg 61801 ctctatttta taggcttctt ctctggaatc ttcttcatca tcctcctgac aatcgatagg 61861 tacctggctg tcgtccatgc tgtgtttgct ttaaaagcca ggacggtcac ctttggggtg 61921 gtgacaagtg tgatcacttg ggtggtggct gtgtttgcgt ctctcccagg aatcatcttt 61981 accagatctc aaaaagaagg tcttcattac acctgcagct ctcattttcc atacagtcag 62041 tatcaattct ggaagaattt ccagacatta aagatagtca tcttggggct ggtcctgccg 62101 ctgcttgtca tggtcatctg ctactcggga atcctaaaaa ctctgcttcg gtgtcgaaat 62161 gagaagaaga ggcacagggc tgtgaggctt atcttcacca tcatgattgt ttattttctc 62221 ttctgggctc cctacaacat tgtccttctc ctgaacacct tccaggaatt ctttggcctg 62281 aataattgca gtagctctaa caggttggac caagctatgc aggtgacaga gactcttggg WO 00/09525 PCT/US99/17712 EPI-109 865 62341 atgacgcact gctgcatcaa ccccatcatc tatgcctttg tcggggagaa gttcagaaac 62401 tacctcttag tcttcttcca aaagcacatt gccaaacgct tctgcaaatg ctgttctatt 62461 ttccagcaag aggctcccga gcgagcaagc tcagtttaca cccgatccac tggggagcag 62521 gaaatatcta tgggcttgtg acacggactc aagtgggctg gtgacccagt cagagttgtg 62581 cacatggctt agttttcata cacagcctgg gctgggggtg gggtgggaga ggtctttttt 62641 aaaaggaagt tactgttata gagggtctaa gattcatcca tttatttggc atctgtttaa 62701 agtagattag atcttttaag cccatcaatt atagaaagcc aaatcaaaat atgttgatga 62761 aaaatagcaa cctttttatc tccccttcac atgcatcaag ttattgacaa actctccctt 62821 cactccgaaa gttccttatg tatatttaaa agaaagcctc agagaattgc tgattcttga 62881 gtttagtgar ctgaacagaa ataccaaaat tatttcagaa atgtacaact ttttacctag 62941 tacaaggcaa catataggtt gtaaatgtgt ttaaaacagg tctttgtctt gctatgggga 63001 gaaaagacat gaatatgatt agtaaagaaa tgacactttt catgtgtgat ttcccctcca 63061 aggtatggtt aataagtttc actgacttag aaccaggcga gagacttgtg gcctgggaga 63121 gctggggaag cttcttaaat gagaaggaat ttgagttgga tcatctattg ctggcaaaga 63181 cagaagcctc actgcaagca ctgcatgggc aagcttggct gtagaaggag acagagctgg 63241 ttgggaagac atggggagga aggacaaggc tagatcatga agaaccttga cggcattgct 63301 ccgtctaagt catgagctga gcagggagat cctggttggt gttgcagaag gtttactctg 63361 tggccaaagg agggtcagga aggatgagca tttagggcaa ggagaccacc aacagccctc 63421 aggtcagggt gaggatggcc tctgctaagc tcaaggcgtg aggatgggaa ggagggaggt 63481 attcgtaagg atgggaagga gggaggtatt cgtgcagcat atgaggatgc agagtcagca 63541 gaactggggt ggatttggtt tggaagtgag ggtcagagag gagtcagaga gaatccctag 63601 tcttcaagca gattggagaa acccttgaaa agacatcaag cacagaagga ggaggaggag 63661 gtttaggtca agaagaagat ggattggtgt aaaaggatgg gtctggtttg cagagcttga 63721 acacagtctc acccagactc caggctgtct ttcactgaat gcttctgact tcatagattt 63781 ccttcccatc ccagctgaaa tactgagggg tctccaggag gagactagat ttatgaatac 63841 acgaggtata aggtctagga acatacttca gctcacacat gagatctagg tgaggattga 63901 ttacctagta gtcatttcat gggttgttgg gaggattcta tgaggcaacc acaggcagca 63961 tttagcacat actacacatt caataagcat caaactctta gttactcatt cagggatagc 64021 actgagcaaa gcattgagca aaggggtccc atagaggtga gggaagcctg aaaaactaag 64081 atgctgcctg cccagtgcac acaagtgtag gtatcatttt ctgcatttaa ccgtcaatag 64141 gcaaaggggg gaagggacat attcatttgg aaataagctg ccttgagcct taaaacccac 64201 aaaagtacaa tttaccagcc tccgtatttc agactgaatg ggggtggggg gggcgcctta 64261 ggtacttatt ccagatgcct tctccagaca aaccagaagc aacagaaaaa atcgtctctc 64321 cctccctttg aaatgaatat accccttagt gtttgggtat attcatttca aagggagaga 64381 gagaggtttt tttctgttct ttctcatatg attgtgcaca tacttgagac tgttttgaat 64441 ttgggggatg gctaaaacca tcatagtaca ggtaaggtga gggaatagta agtggtgaga 64501 actactcagg gaatgaaggt gtcagaataa taagaggtgc tactgacttt ctcagcctct 64561 gaatatgaac ggtgagcatt gtggctgtca gcaggaagca acgaagggaa atgtctttcc 64621 ttttgctctt aagttgtgga gagtgcaaca gtagcatagg accctaccct ctgggccaag 64681 tcaaagacat tctgacatct tagtatttgc atattcttat gtatgtgaaa gttacaaatt 64741 gcttgaaaga aaatatgcat ctaataaaaa acaccttcta aaataattca ttatattctt 64801 gctctttcag tcaagtgtac atttagagaa tagcacataa aactgccaga gcattttata 64861 agcagctgtt ttcttcctta gtgtgtgtgc atgtgtgtgt gatgtataca aagagagaga 64921 taattgtatt tttgtatttt cttttaaata atttttaaaa ttgacccttt tcctgagaca 64981 aattgccaga atagtttgta tttagagatg gtacctctaa gagtaaggtt gctggttgct 65041 gagcaattga cttgaaaact tttaaaattc aaattttaat tccactactc aaaagaattg 65101 ccatgtttta aaaaagagaa ttggtgccat aagttagttg tctatgtttg aaaatgaaga 65161 agatatgcaa cgtcatggcc tggtcactta cccgcagccc tgagttgtag gcacatcata 65221 tgtgagaatg aggatgcttt tctttcattt aaaatccctc cccaaaactt ggctctaatt 65281 gcagtcatga caatcatgta catttggatt tatgtgcacg agtctcttac cctgagagag 65341 gacaggtgct acaggtggag gggacccgtc tgggtcacgt tcacattttg aacatgctgg 65401 ttttcagtca ctgcacactc atctcccagc gcaggtcatg ggcagcagat gcaaaagctg 65461 cccgtggtcc tatttggagg tgcatgaaat gagcagaaga cagaatagct tgatctgact 65521 agaagggcag cttgtcccta ccaagacttg aaggattgcc tttcatctgt tagggtaaaa 65581 ggtagaatga accaaggaag ggcaggaggg ggctggggtt agggtagaag gaaggggcca 65641 tggagaaggg agatccatcc cataggagga aggcagtgcg gcagggaggt ttgaaggtat 65701 cagcttttgt ggctgacata catgcagtca tgtcaattgc tcgtttttcc ttttccatct 65761 tattaaatgt cttccaatgt tagcacgaag aaaagctatt tgcagtgttg ccagcctttc 65821 cagagcccgt ccccattacc tccccaggcc catgccttta ctccttggag tttcaactca 65881 cgaccttcag gatctgactt tattcaccaa ctctggggtg aacgtacctt ctgtctccac 65941 ccagaggtct ctatcaaaga ggagattgca tgccatggat aaagtcaaag tagaggtgac 66001 tgtccttagg aagagtaatg tgaaaattca taaactggga ttctgtttac attttgtact 66061 ccaggggttc ttagtttaaa tcgctctgaa taaattaaga tgcaatggca tttcaactgt 66121 tatgattaaa rttacaaatc atttattttc tatcacgggg agagatagag ctccaaatgc 66181 aaacataact gctcaagtgt taacacttat aatgaaaaca taagaattac caccaactac 66241 cctgggggct agaagcagaa atgtgaacca gaaaacaaat catgaacttt cctttttttt 66301 tttgagatgg agtctcgctc tgttgcccag gctggagtgc aatggtgcga tctcggctca 66361 ctgcaaccac tgcctcccgg gttcaagcaa ttctcctgcc tcagcctcct gagtagctgg 66421 gactacaggc atgcaccacc acgcctgggt aattttttgt atttttagta gagacagggt 66481 ttcaccgtat tagccaggat gctctcgatc tcctgacctc gtgatctgcc cgcctcggcc 66541 tcccaccgaa gtgctgggat tacaggcatg agccactgtg cccggccaac aaatcatgaa 66601 ctttctaact gcagttcctt gtagcttgtt aacacatcca cttacttatt gtcagagtac 66661 gtggagattt tccacaaccc tcggggataa ggctgaacag aagaggcaaa aacgtgaaaa 66721 catttcgata actcctatac tttgaaataa aattcactgt aaaagttgct tgtatttttc 66781 caaaacagag tcaaccctta atatttaaga ttctgtatac aaatacatat ttttatataa WO 00/09525 PCT/US99/17712 EPI-109 866 66841 ttaatatata ttgtcatatg acatatatct ttatattaat atgcatgcat ataatatata 66901 tttccttcct aattttctat aagcaatttt acaagactga cttctatttg cctccttatt 66961 gttactacgt ggtttgataa tccgttttgt gtcattgtga ttctgtcatg ttttggggac 67021 ttatttttgt ttctctgggt ggtcactagt ttttttaaag cattcatgga agagtgtgaa 67081 tcttttacaa gctaggaagc catggcaagc cttgggtcat actgcccccg cgaggccaca 67141 ttggcaaacc agcaagggtg ttcaacttcc agacttggcc atggagaaga catacgagga 67201 ggcttttcac attcagctct ttaatgtttg tctctgccgg caccatccca gttgtgaata 67261 agaggtattt ccacagcggc tcagggtagg tagtgcacag ctcacattca tcatttctga 67321 aaaccgagag gagtctccat tcggggtaca ggttgatgcc tgtcgtggaa tgaaggttcc 67381 aacacccaga ccaatctctg cagtgtgctg ctctcatgag cttgcaacaa gatcagaaaa 67441 tgttttgtga ctaagcattt ttcatattgc ataaaatgct tcaagctcct cccttgtttc 67501 tctctataat cctgtatat.c tgatgattgt gggtaccaag tgtttgaaat aatcaaatgt 67561 gatttgatgt tggtaaattt cttttttttt ttttttttac ttctattttt tttattatac 67621 tttaagtttt agggtacatg tgcacattgt gcaggttagt tacatatgta tacatgtgcc 67681 atgctggtgc actgcaccca ctaactcgtc atctagcatt aggtatatct cccaatgcta 67741 tccctccccc ctccccccac cccaccacag tccccaaagt gtgatattcc ccttcctatg 67801 tccatgtgat ctcattgttc aattcccacc tatgagtgag aatatgcggt gtttggtttt 67861 ttgttcttgc gatagtttac tgagaatgat ggtttccaat ttcatccatg tccctacaaa 67921 ggacatgaac atagcaaaga cttggaacca acccaaatgt ccaacaatga tagactggat 67981 taagaaaatg tggcacatat acaccatggt aaatttcttt atcattcgca ctctcctttc 68041 tctattattg ttattgtaac tgaaccgcag attagtcact cattgcttgc agaatccaat 68101 taacaagagc gaggtcagat ataaagaaaa tgatttattc caaacctcct tcagggaaga 68161 ggtgcagcct cctgcctcta aatgcactgc ttcgccaggc gtggtggctc acacctgtaa 68221 tcccagcact ttgggagacc gaggagggca gatcacttaa ggtcaggagt tcaagaccgg 68281 cctggccaat atagtgaaac ccctgcctct actaaaaata caaaaaatta gccagacgtg 68341 gtggcgggtg cttgtaatcc cagctactcg ggaggctgag gcaggagaat cgcttgaacc 68401 tgggaggtgg aagttgcagt gagctgacat ctagccactg cactccagcc tgggtgacag 68461 agtgagactc tgtctcaaaa taaataaata aataaataaa taaataaata gtaaatgcac 68521 tgctttgctt ttggagcaga aagcaggcac tttgaaaagg caggggagga agtgagcaag 68581 ggcagggggt ctgcacactg gcatggtgcc tgatctatcc aggcagttga attggcactt 68641 tcataggcag aaataagttg aaaaagtggc ctaaaactct ctaggtggga gtggatagtg 68701 ggcatgcctt caacctgcct ttctggaggg tgagttccat ggcaaccccc tgaagggtga 68761 gagttccatg gagatcatgc tttggtctgt aaatcagctg ttaactctct agaaagttct 68821 gtcttggagc atatagttag atgaacttgc cctgtaaaga atgtctggtg aaggggaagt 68881 aaaaggtgag atttgcattt ctaaagggct aagtagaacg tggggtacaa gaggaaagga 68941 gaaaagagaa aataatttaa aaaataattg taacttattc ccttttactt agaaaaaagg 69001 gaatactcag ttacattatc acctcgttta catcaaaccc tcttatggaa tcctatggtt 69061 tgaaaacaaa aaggttgttg aggaccagtg agcccaaccc ctttgcttta taaatgaaga 69121 gcattgcctg ccctaagccc cagagactct gatgtcgtgg gtctggagtg ggctccaaca 69181 gcggcatgtt ttgatggtgc ttcccagtgg cacgccagcg atgagccttt gagtagggaa 69241 agtaggagca ctcgtgactc ccttcacgat cagcacctgt gtgctaataa attcacaaaa 69301 gccaacatat tggagtcact cagggagttt tacaaatagt gaggttaaat ccaacctcaa 69361 atagttctga ttcgatctgc ctgcattgct gccctgtggt tccccactgt agaagctccc 69421 caggtgattc taagtgtagc caagtctgag aaatactgcc taaagcctgt tggactgaca 69481 gcaagggctg ttgtctgagc aagactttgc ctggcctggg gtggcatgtg caccaggaag 69541 agtctcaact ttcataacag aacattcccc aagctggttt ttttaaagca tgtgaatcta 69601 gacttcattg gcaataccaa agatctgtat ttgaggctcc aagtatttca ctttcatttt 69661 tggttttggg ttatgttttc acccttcctt tccaagtgaa aagtaaacag aagtgggatg 69721 tctggcgccc atgctgagct tggcaacttc aaattcaata gagaagaagt ctcttgtata 69781 gaaaagggcc tgtctgagat gtttctcaaa taaatataga ttttgcttat gtggctaaag 69841 gattcttctc cccccatttc cttatccctg cagtgagcca tccttcttaa ctctttccat 69901 gaaagcatta ttcctgaaga actgggaact catgccagcc ctgatcaggc aatgataatt 69961 ctgcagagaa ttagaattta gatttaaatt gtcaactctt atacatcctg gcatatggtt 70021 taaacacatg tacacacaca caaacacctc ctactattta ctgaagagca gatatctgat 70081 aacttaatct ttttggtttt gagtcaagac aattcctcct tttgaaactg cataccgctg 70141 aatataataa aatgtaatta agattaaaaa taagaaacta atgggagaat ttcaatattg 70201 tctctgttca ctttaaaatt cctctactta ggtttactgc cattaccaaa gactattcaa 70261 aaatcctttt taggagaatc ctaatggttt cctgacatat aatcaaataa ggactctgtt 70321 gattggctaa ctcaatcttc ctgtgccaaa aagcagagcc cagcagagaa gagggcaggg 70381 acttgaaagt cagactgact cgagttccag ccttggggct gtgggagctt gggcaagtga 70441 cttaacgtct ctggctctca ggatctaaaa ggatttccag tagtaatttg gggtgttact 70501 gatacaggag ctaaaaagaa attatttagg tggttagtga gggtcagaga gtcctcggta 70561 agatttgcct tttaacaaaa agcagcccca aaatcatttg tttgctaaca aagagaagcc 70621 tgtaaaattg agctgcagac atagataagc aagctggaag cttgcacggg tgaatgccgg 70681 cagctgtgcc aataggaaaa ggctatctgg gggccaggca tgttcaacat ggattctcca 70741 tcttcccttt tctttgtcaa ccaagtgtac agtaaaggaa caggcaacat ggcacgggcc 70801 aggtagagaa cccttctgca taataaaaga ttagggtgag atggccagct tcttcccgtg 70861 ctatgtaaat ggcatacctg gtccaaccag tcttttgggc cctgtgtaaa tcagacaccg 70921 cctcctcaag ttagtctata aaaccccatg cattttaccg tgaaactggg agatccactc 70981 ggaaccccct cctgcacgag agaccttttc tcttttgcct attacacttc cgctcttaaa 71041 ctcactgctc atgtgttagc atccttgatt tccttggcat gaggcaatga accttgtgta 71101 ttaccccata caaatgatgc tgcttcatta ctaatagcaa cctgacaggg ttgtgttggg 71161 gtataaatta tctagaccag ggagatccaa tataattttt ttgtaatgac gggaatgctt 71221 tgtatctgca tcatccaaaa tggtagccac caggccaggg tgaaatgtgg ccagtgtgac 71281 tgaggaactg aatgttttcc atgatttaat ttaaatgtgg ccaatggcta ctgtaggaga WO 00/09525 PCT/US99/17712 EPI-109 867 71341 cagtgtgagt ctggcatatt ataaataata aatattaata taatttgaac tttggcatca 71401 gtgtttccta gatttgaatt actatgcaag ttgcttactg tttccaagcc tcagctttct 71461 aatctgtaat tggggctaat aatagtatct gccttacagg tttgttcaga ggataaatga 71521 gaaattgcat gttgagggct taacacagtg cctggcacat aaaagctctg gtaacagtta 71581 gccactttaa taatttgcta ataatggcta tttcttcttc agattaggat gtgctccccc 71641 aaacagtgca cttagacata gcgggcaatc cagctcactc tctgcagtga gagagaagca 71701 ctggccgacc agagtcagcc aggggctcat gggtatgaaa tcaacagcat gattttgtaa 71761 gtaatggatg gaaagggcct cacaacttta tggcactgtg ttcaatttgc ttggtcttct 71821 gtagctcctt ttgaaagcct tttagggtgg attaacctgc taccaataat tctggtcaga 71881 tgtagactcc atagctcaaa gcaaactgag agagtgaggg cagcaggcca attccccacc 71941 ccttccttct ggactctgac agaagcttac actcaaggaa gagcaagtag gaattaacgt 72001 gttaagagct aggtaagcaa aacccaatga gaagttctgg caaagcccca tgggcagggg 72061 tggcttaggc acaggaaaca agtaggattt cataccacgc gcctcagtct acttccgggg 72121 ccctcatcct cagctgtgcc tatgcaaagg agagcaacca ataaacccca ccgccactct 72181 cctactgtgg aggccaggga tggccagggg taagagaggg atgggaagtg tttcctccag 72241 ccgtcctctg agaaggagag gaaactgggc agagcttctg tcctccttca agcagaaaca 72301 gaaacaaaag aaacccctaa gggggttctt acttcccctc tagttcagtt gtgcactaac 72361 catctgcagc tcaacattca gcattcattc attgattcag caaacattga aggagggcca 72421 gctatgtgcc agatgccaac tcatgccatg aaagagagtc cctgtcctta tgaaattcac 72481 tatttagaga gaaaagcaag caaaaaggca aagtttgaaa agtactgttg aagtggcatc 72541 attgtctggg gtgaatacct gaggtttgtg gtctcacgcc aagggaatca aggactcagg 72601 cacacaagaa gtgagtttaa gagcagaggt ttaataggca aaagaaagag aaaaaagaat 72661 agctctcttg cctgcacaga gagaggggca cctgagtgga tcttcctgtt ttgtggtgaa 72721 atgcaaggca ttttatagac gagcttgagg aagtggtgtc tgatttactt aggacccgag 72781 agattggtca gaccaggtgt gatgtttaca tagcatacaa agaagctggc catcccatcc 72841 taatctttta ttacgcagac ggggtctata cctggctggt gccatgttgt ctgttcctta 72901 ctgtacacgt ggttgacaaa gaaaagggaa gatgaagaat ccatgttgaa catgcctggc 72961 ccccagatag tcttttccta ttggcacagc tgccggcatt cactcttgca agcttccaga 73021 ttgcttatct atgtctgcag cccaatttta caggttgctc tttgctagaa aagaaatgat 73081 ttgggggctg cttttcatta aaaggaaaac cttaccaagg ttaaaaagaa aaaaatttct 73141 ttttaatgcc tatgttactg tgaacagtgt cgggataagg ctctgagagc cagatgagga 73201 tgagttatcc aatccaagga tgggggtctg gaggaaaaaa tcctagagag cattgctgca 73261 gttgaataag gattagttag aagctactga gtggagcata ggagtaggaa ctcttatgca 73321 aatgtgcaga ggtgaaataa agcaaggtat agtccaggtg cctaaagtag cacagctgac 73381 ttgagataga tgatagatag gtagatagat ggatagggta catagatgat agatagatag 73441 atagatagat agatagatag atagatagat agacagacag acagacactg gtgtgagtgt 73501 gggtgtgtgt gtctggctgc gtgcatgcat tcctcctgca ggagatcagg agcagtgggc 73561 agtatggagt gacaagaaga ttgggaggta ctccttctag ccctcccctc tgctctgccc 73621 tccactggag cagaagcaaa gcatatggtg aaggggaaca aggagtctcc ccagcacagt 73681 acccgagtgc attagctatt tatcactcca cagtccccat tcacgtgtta attcagcatt 73741 tattgaatgc ttactgtttg caatgtctat gtcaagctgt caagtgtagt ttttattcta 73801 caggccacag gcacccccta actgtgttaa acaagatggt agtattgaga caggaataat 73861 aagggtggtc acaggagaat ggaagattcc aggcagcagt ttgactagta aaaaaggaaa 73921 ctgttgaaat agctgcataa tccaggggtc aataagaacc tgagaaccag ggtgtgagcc 73981 aaggctggtt aaaagcaact ggatccaata tggtgctgag tttctcctag gttttgcctg 74041 gaacctcatt atatgctcaa taacatacca aatcacacac ccaccagggc cattccattt 74101 cctggaacac tcatgtttgg tgtaaaaatg ggtggcacca cagctctgag aaatctttac 74161 ctttttcagg aaacttcatg aatattccat cctttggtta aagaaaccca taatgtagaa 74221 gccccaaacc ctactgggc'g caactctctc tctcttgagt atgcctgcac ttccctttat 74281 tatttattta tttatttatt atttatttat ttatttttta gatggagtct ggctctgtca 74341 cccaggctgg agtgcagtgg cgcagtctca gctcactgca agctctgcct ccagggttca 74401 ggccattctc ctgcctcagc ctcctgagca gcagggacta caggcgccca ccacaacgcc 74461 tagctaattt tttgtatttt cagtagagat ggggtttcac catattttat tttatttttg 74521 agacagggtc tcactttgtt ggctcgctgc aacctctgcc tcccaggctc aagcaatcct 74581 ccaacctcag ccccccaagt agctgggagg acagacgtgc accaccacac ctggctaata 74641 ttttgtattt ttttttgtag agacagggtc ttgccatgtt ccccaggctg gtcttgaact 74701 cctggactca ggtgatcagc ctgcctccac cttccaaagt gctaggatta caggaatgag 74761 ccaccccacc cgaccacact cccatttctt gagtgtgtgc attttgctct gcaataaatc 74821 tctctacttt cacttttctc tgactcgtcc ttgaattcct tcttgtgaca gcgtcaacag 74881 cctggacacc aggtgcagtc aacgtctcac cagtgtttag ggacctcccc taatccactg 74941 gtatcagcat gatcagactt gctttttcag aaaaagcctt ctgtccatag accaaaggga 75001 agtgactcag agaaggggca ggaggaatca caagctccct gcctgaccag gcctggacta 75061 tggcagagac agtgagatgg tgagaaagca agggtagaca gccagccaaa tccagaatat 75121 agaaagttct acaggaaaag gtggggccaa ggtgggacag ggggaaagga attgttgcac 75181. attaacagtg caatgcagag cactggtctt gtttatgtcc aggttagaac aaaccaatga 75241 gaaagcacat ctttgagaca actggagaaa tttgaacact gactagatat aatattatgt 75301 taattatgct ttaatttggg gtacaataat gcttttgtag ctatttctaa agagtcctta 75361 tctcttaagg atacactcta aaatactagt ggattaagtt atatgatgtt tagactcttt 75421 ttaaaataat ccagtggggt gagaggcaga gggaagggag aggagcatag aggaaacagt 75481 gttggccata tgtttgtaat tgttaaaact gagtgatggg aatatggaga tttaacatat 75541 taatactatt ttctgcccat gtaatatttg aatattttca taataaaatt gagagagaga 75601 taaagaaaga aaagagaaaa gaagagaaga gagaagagat aagggaagtg gaggaaaaag 75661 agctttcttc aaggaccatt gtggtggaca caaatgaaag ataccccctt cctactatga 75721 attctaggtg tgtactaccc aagatgagtc aatcggatcc tagcttccag aaatcgtgag 75781 catgatgcag ccctacagac gcagtgccct ggaaaggaga cccatgacca tccaaggaag WO 00/09525 PCT/US99/17712 EPI-109 868 75841 atgtcccatc acagaactgc cctgggtcat gtgttttcca agtccacatg tccggtagtt 75901 ccttctttcc tatgaccaat gccaccagtc ttccagcact gtcctttatt gctaggcaaa 75961 cctgagccat cctcttcttc ttgcaacttg tgcctgaagt aacatggaca caaagtcccc 76021 acttttccca cattctcaga atgaagtagt tctccctcca cactttaggt gctagaggca 76081 agtggattgc ttgagctcaa gagttcaaga ccagcctgag caacatggca aaaccccgtc 76141 tctacaaaaa atacaaaaat taactggggg tggtggtgtg cacctgcagt cccagctact 76201 caggaggcag agaaggagga tttcttgagc cctgaaggtg gttgtgttac gtgcattcat 76261 gttaagagac caccaaacag gctttgtgtg agcaattaag ctttttaatc atgtgggtgc 76321 aggcagactg agtctgaaaa aagagtcagc aaagggagat agggatgggg cggttttata 76381 ggatttgtgt aggtagtgga aaattacagt taaagggggt tgtcctcttg cgggtacagg 76441 cgggggtcac aaggtgctca gtggggagct cctgagattt attgtccagg agaaggaatg 76501 tcacaaggtc aactgatcag ttagggtggg gcaggaacaa attacaatgg tggaatgtca 76561 tcagttaagg caggaactgg gtattttcac ttctttgtgg ttcttcagtt gcttcaggcc 76621 atctggatgt ataagcgcag gtcacagggg atatgatggc ttagctcggg ctcagaggcc 76681 tgacattcct gtcttcttat attaataaga aaaacaaaac aaaatagtga tgaaatgttg 76741 gggcagcgaa aatttttggg ggtggtatgg agagataatg ggtgatgttt ctcagggctg 76801 cttcaagcag gattaggggt gacacaggaa cctagagagt gagagagatt aaactgaaga 76861 aagattttgt ggtaaggggt gatattgtgg ggttgttaga aagagcaatt ctcatataga 76921 atgattggta atggcctgga tgcagttttg tatgaattga gaaactaaac ggaagacaca 76981 aggtctgaat aagagaagga gaaaaacagg cattaaagga ctaagaactg ggaggaccca 77041 ggacatccaa ttagagagtg cccaaggggg ttcagcataa ttatttgctt ggttggtgag 77101 tttttggtct ccatccttga gtttttttta tgttgtcata tgccaggcca gattgattta 77161 ggtaaaaaca acactcttca tttaaaaata tacagagttc tcctttctca gcagtgagta 77221 agtcaaggcc tcagcagttt tggaggaaag agaaatgcaa aggaagcaat tgtttgttaa 77281 gaaggattag aaatggctag gagagagtga gtgagattga tagtgtggtg gagatagctg 77341 aggagaggta gagggtggca taagaatggg aacgagaata agagtgagta taaaagtaaa 77401 gaatagaact tcatcagggt gaaagtattg gagggtgccc tgtcagcaaa gatcatctgt 77461 ccactccaag agggagtcaa gagtggcgga ttggggatag taccaggaga tatccactat 77521 gatggtttgg aggaaaagtg taaactggca gtgtaaacag gggcagggca tttatgagtc 77581 attgagaatg gtgaatagga gtatgactag acagaagata gtggagatga caaattttgg 77641 gggcacagtc caaatagtgg gggtgactgc gtagagctct gttgcaaaaa gtagggtaag 77701 gataaataga cttaatagaa tgaagagatg tattaggctc ataagggtta ttattgttct 77761 tcagaaatgc gagtgagttt aagggaagta ggggtgagta cttgcgactt ccagaaggaa 77821 gaggagagat caggctggct gtctgatggg cacagcttta ttctggaaca gtgaatccaa 77881 tggggagggt cgtgcagacg gatggcagtt ggggtgctat aaatgaccag gtagggtcca 77941 gtccatcaaa gctgtagagt gtgaggggtc agacttgaca aggactgatt gcccagctaa 78001 ggtatcttca catggctggg agtttggagg aggcaagaga agattagcag cctggcgaat 78061 ttcctgtcta gcctgctgga ggactggaag ataaaggcaa caggtcgtgg gcctggatcc 78121 tgtgtgagga ctctagcagc acagccttgt atttcagctg tgtgtaagga aaaaggatgg 78181 gacgagtcgg ggagtgctag tgtgggagct gtctccaggt cctttttgag agagtgaaag 78241 gaagaatggg gaaaagactt atggtctatg ggattagtta aattaccctt tgtgagctag 78301 taaagtggtt tgattaggat agcaaagccc ggtatccaaa gttggaaata tccaacaatg 78361 cctaagaagg aagggagttg ttgtttggtg gtgggggttg gggtctggga gattaactga 78421 acagagtctg caggaagggt atgtgtatgt tgatggagca ttataccaag ataggtaatg 78481 ctaggggaag aaatttgtgc ctcagagggc aatactttgt acccctttga gtaaagatgt 78541 tgaagaagca ggctagtgtc ctgctgggaa gattggtaag aggggctgca aagaagaaga 78601 tcatcaacat attgaataag gtgggaggta gatgggtgaa aagaaagcag atcatgagaa 78661 agggcctggc caaagtaatg tgggctgtcc ctgaagcctt ggggtagaaa aatccaggtg 78721 agttgttggg actggtgggt gtcagagtca gtccaagtaa ggcaaaaaga ggctgggagg 78781 agggatgcaa ggggatagta aagaaggcat ctttgaggtc gataacagaa tagagttgtg 78841 gaagggtgta ttgaagatag gagggtgtac gggtttggca ctataggatg gatgggaagg 78901 acgatttgat caacaagacg aagatcctga acaaacctgt aagacttgtc cggtttctgg 78961 acgggtagga taggggagtt gtaaggagaa tttgtaggct ttaagaggcc atgttgaaac 79021 aggcaggtga taacaggctt taaccctttt aaagcctgct gtgggatggg atattggcat 79081 tgagcggggt aagggtgatt acattttaat gggatgataa ggggtgcatg atcggttgcc 79141 aaggtaggag tagaggtttc ttatacttgt ggattaaggt ggggagatac aaggggagga 79201 tgtgaaacag gtcttgagtt gggtaaaagt gcagcaaaga gatgtggctg cagcccagga 79261 atactcaggg aagcagataa tttggttaaa atgtctcagc ctattaagga agctggacag 79321 gtggggataa ctaaaaaagt gcataaaaga atgttgtcca agttggcacc agagtggggg 79381 agttttaagc ggtttagaag cctcgccgac aatacccaca acagttatgg aggcaaggga 79441 aacaggccct tgaaaagaaa gtaatgtgga gtgggtagcc tccgtattga ttaagaaggg 79501 gacagactta ccctccactg taagagttac ccaaagcatc tgtgatggtc caggaggctt 79561 ctgaggtgat caggcagtgt cagtcttcag ctgctaagct gagaagatct gggaaggagt 79621 cagtcagaga gccttgggcc agagttccag gggctctggg agtggttgcc aggcaagttg 79681 aacagtctga tttccagtgg ggtctcgcac agatgggaca ttccttggcc cagtggccag 79741 atttccggca cttgaaggaa gatcctgggg gaggaggtcc tggagaaatg cctggcccct 79801 gcagtttagg tgttttgaag ttcttgtgtg ctggagatgt ggctggggtt tctcttacag 79861 cggaggcaag taattgcaac tcagaaatat gttgtcactt ggctgcctct tttctattat 79921 tgtacacctt aaggcgaggg taattaaatc ctgttgtggg gtttgagggc tggaatctaa 79981 tttttggagc tttttctaat gtcaggagca gattgggtaa taaaatgcat attgagaata 80041 agacggcctt ctggcacctc tgggtctaga gaggtaaagt gtctaagggt tgttgccaaa 80101 caggccatgg actcagctgg gttttcatat ttgatgaaaa agagcctaaa cgctaactga 80161 tttgggagag gtcagctaaa gaaaaaggag cattaacctt gactatgcct ttagctctag 80221 ccacctctct aagaggaaat tgttgggccg gtgggggagg gctagttgtg gaacgaaact 80281 gtaagccaga ccaggtgtga ggagagaagg tgaccaaagg tttatagggt aggggagcag WO 00/09525 PCT/US99/17712 EPI-109 869 80341 aggctgggga agaattggga cctggctagg cctagcgagg aacagcctgg ggaggagggg 80401 agaaatcaga tgggtccgta gaaaaggagg attcaaagga ctcagagctt ggggtggaga 80461 ctgaaggaac agacaggaga gaaagaggaa agatttggga tgagtcacat tgggagcaga 80521 gactagagag ggactgatgt gtaaagaatg cctggacgtc aggcacctca gaccatttgc 80581 ccattttacg acaaaaatta tctagatctt gtaggatgga taaatcgaaa gtgtcattct 80641 ctggccactt ggaactattg tcaagtttgt attggggcca agcagtatta cagaagaaaa 80701 taagatgttt aggtttttaa aagagtgcat aaaagaatgt tgtccaagtc catgcccttc 80761 ttaatcaata tgggagctac ccactccaca ttaccttctt ttcaagggcc tgtttccctt 80821 gcctccataa ctgttgtggg tattgatggc caggcttata agccccttaa aattacccca 80881 ctctggtgcc aacttggaga ggtcaggtgt tagtcaaagg tgttttaagt tttaagaaca 80941 caggctaagg gagaagaagg gggaatgaag cgtggaaggt tgcccatagt gaaagaggta 81001 agtttaaaga gaaaggtaga gacatggaga aggggggagg tgagcagccc tgggctgtca 81061 tgtgggttag cagccaaagc tggtgtccca gcaattgact taccaccaag ggaatgtggg 81121 tgaatgacca aggcaggcat ccccccggtg atcagacacc aaatggaatg tgggtgaaag 81181 atcaaggtag gtgtccccat gatgatcaga caccaaagga aggctgtctt cccaaatcca 81241 tgatccatgt tggagttttt gagttcatgg ataaaatgtg tctcctttgt ctctactaga 81301 gaggaaaaag aactggaatt tgaaggacag ggagattgaa gggtagggag agaggctgaa 81361 gaagagagtg aggagaccgc ttacccggtt tgaaattggt gagatgttcc ttgggctggt 81421 ctgaggacct gaggtcgtag gtggatcttc tcatggagtg agggtgagga gaggggacca 81481 atctcccgaa ggagtcaccc tgtccggggt cttcggcacc aaatgttatg cgcatccata 81541 tgaagagacc accaaacagg ctttgtgtga gcaataaagc tttttaatca tgtgggtgca 81601 ggcagactga gtctgaaaaa ggagtcagca atgggagtta gggttggggt ggttctatag 81661 gatttgggta ggtaatggaa aattacagtt aaagggggtt gtcctcttgc aggcaagggc 81721 aggggtcaca aggtgctcgg tggggagttc ctgagactca ctgtccagaa ggaatgtcac 81781 aaggtcaatt gatcagttgg ggtggggcag gaacaaatta caatggtgga atgtcatcag 81841 ttaaggcagg agcggcctat tttcacttct tttgtggttc ttcagttgct tcaggcaatc 81901 tggatgtata tgtgcaggtc acagaggata tgatggctta gcttggactc agaggcctga 81961 caggttgctg cagtgagcca agatcacact actgcactcc tgcctgggca acagagccac 82021 aaaaaaaaaa aaaaagaaaa gaaaagaaaa aaaaagaaga agaaaaaaaa attttttttc 82081 caccaagaat ttagtaaaaa attataggga aaagtgtcac taattcaagg gaattgcact 82141 gaaaattatt cattcattca acagatattt attgagaagc aagtatgctg gtgctagggt 82201 tacaacagcg cacaaattct tgtattcaag gaatgaggta agagtatgca gataggagcc 82261 agagaggtca agaggcaatt gcaacataga gtgacacgtg ctccagaaca cataggaggg 82321 cttccaggcc ccatgctggg ctatcagagc tggcttcctg caggtggtgt ggctcagcta 82381 aaacctgaga accaagaatg agccttctga tatctcaggg ttaaatcggc acaaatgaaa 82441 ccattttata accaaacaac attttccctc ctgaactgca ctttttctag aacccattta 82501 atccttccta acatgttcaa tccagccccg tgatttttca gtcaaatgca agatgcgtag 82561 gattcctttt ctgttcagtg ctccccagcc aatctttttc ccttctccca ccccacagtt 82621 actaattcca gcgtttcagt tctcagcaga ggatgacagt tccaccagga gacatcagtg 82681 ttatctggag acattttagt tgtcccagct gagggcacag tgctgctggc atctagtggg 82741 tgaaggtcag gaatgcacct caacatcctg gaacactcag gacaatcccc agcaacaaaa 82801 acctacccat ccagaacatc aacagggctg tggctgagga gccctgctct agtgcttcct 82861 ccttactgta tcctcatcaa ggagggctct ggggcatgtc aggggctgct acaggctcct 82921 ggcagatttc ggcgacttac tccagacttg tggaacattc aggattctta gcatggccac 82981 aggagagtca ggctgtccac aagcactctc tctttcttca cccactcatt cctgtcactc 83041 taccatttcc actgccttcc caaatgccca tcgtgagtcc caccaggggc cagaacacca 83101 ctctctcaag cctccccagt ggcgcgtgca cacctggaga acatgtctca catcccccag 83161 ccagcgagac gtcctgagat tccagcactt ctcagtgtct ttcccagctt gtttgtatct 83221 ggaatggggt ggggtctctc acacaggaga aattacaagg aaaagtgtac gtgacaggaa 83281 tggaggaatt tctgtggaaa cggtgtgtga gaaaatgtag gaagaaagaa acttcaggaa 83341 atggtaagtg gcatcttgag agcagaaagt gagaagggag cagaaagaaa tggggctgga 83401 acctgggaag gagaggacag gtggggatgg ccttgcacac cgtgggcact gaggagtgtg 83461 ggcccatggc atgggtggag aggagtttca agatagggag tagattccta ttttgaactt 83521 cggattgccc ctggcgatgt ggagactgta ttggaagaag gcaagaatgg aggagagccc 83581 ctaggtggag gtttggcaat gctctctcca gaatatagca gaggcctctt ccaaggtagg 83641 aaagccctga ctggagagaa gttaatggct ctgagggctc aagggaggac ttggattatc 83701 aggactttta gggaggcata tgatcaaggc ttgggtcttg gcccattgaa atggggagca 83761 ctggttttag gatgtgggtc aattagtttg gttttcagga caggctgagt tggatatcct 83821 gggggacctc caggtggcag tgtcagggga agctggatgt gctgacactg aactcagcag 83881 agtgactgag tagagatcga catctggggt cacaggcagt ggatgccgta ggggtggact 83941 caatagctca agcagaaccc ggaggaatgc aggcagcaaa gggagcccta aagaacagtg 84001 aggagatgtg ccaagaaaga gccaaatccg ggggattggc tgtgggagag agggctgtgg 84061 gagtaagagg aagtgtcagc aacgtcaaat gttgcagaga catagagtaa ggtaagagtg 84121 gaaaaaacat ccatggaacc ctgtgatgca atcggaatgc agaaagactt tgtaactcct 8 4181 gcctggtctc ctcctctgcc cactcatggc aaaggaatac aaagtaatgt tccctccttc 84241 cgcctagaaa agcacaactt ctgcccccaa gccctgggct ctcctgagag gacaggacca 84301 gcctctgaag ttgaaggtcc tggttctgcc cccaagccct gggctctcct gagaggacag 84361 gaccagcctc tgaagttgaa ggtcctggtt taccagatag ggaaggggcc ctttccaaga 84421 ccctttccag aaggtgtggc tgagatggga accgtggact ctgtgcagat gtaggagctg 84481 gctccagtca agtgctagga ggttgtgggt cctgggaagg aagaggctct ggagcctctg 84541 tggagactct gggactgtcc ttgggggaga cgtgagcagg aagaagcagg gccttcacag 84601 tccccagctt aggggcctca ccacccagac tgaagaccag gaccaaaccc tttcctgcac 84661 agttacaatg tgtcatttaa ttttactaaa gggaatattt tttaaatgag gatgctactt 84721 tgtgtattaa tttttacctc tattcataaa agaaacgttt cttatctatt taagatgatt 84781 catatcagac cagtgtctgc ccaactcgac tgaccctgtg aaaactgggc acttcacact WO 00/09525 PCT/US99/17712 EPI-109 870 84841 ccaatgatga :ggatgagtc cccagcagca tagtttaagg gagtgagtgg gcagtgtggc 84901 ctcctgtgca cgtgaczzcc tccttcagtg tgcccacatg tgggttccac ggtcttgtga 84961 cattgtggct ttagaaartt ctgtttccat tttctatcat tcagagtaaa tgaaatttgc 85021 aggaaattca gaacctzcca cctgtacagt ggatactgtg agactctgcc cagatgccct 85081 cttcaagcca atgcatctct ccatgctccc actcccatag atgggaacag aggtgctgga 85141 actcagatct actccccttt ctgggaactg gagctgcctg cccaggcaat gcccccttcc 85201 cagggatggc tgagccaatg actggctaat gttggattgc agaggcctag cgccctcccc 85261 tcaattccta attccttgta ggaataactg aggcctcctc tgtgaccacg tgggcagctt 85321 ctccctctgc ctggtcctgt cttgttctct cctttccaat tgtgtctcct ggaagccctc 85381 cccacaagtc zgctgcazac aactctcctt ctcagagagc ctgagccctg gattcccagg 85441 aatccagcct aaaatagzct ggcatttggt ttcaattttc tctttcacta agactcagtc 85501 acaggtgcta ataaataata aaatgtcacc accttgaatt ctatcactct ctcttttctt 85561 gccccatctc tgacaaatag gtggtccctc aagaacctga aaagcagaca ttaggaggaa 85621 aggaggagtg ggggcaagag gcccacacct cacctggccg gctcccatcc atgcgccctt 85681 gactgaggta acacctaccc tgggaatcct tcccctgcct ctcgtgagcc aggccgggtg 85741 ctcttgggac agctcccact gctcctgtgt gctcccccag cttggcacat gactccctga 85801 attatagtca gttccgtacc tgaatctccc tctagaatgc cagtgccacg aggacagagg 85861 acggttccac tttgttcact attttctccc cagggtctgg caaagttcct gggacttggg 85921 agaggtgtcc ttcaggagct tggcagaagc caaacggcac acttaagtag ggcaactgag 85981 gtgagtttaa tgaaggattc tatacaaaaa tttggacaag gtatagggag gccacaatac 86041 acagtgcagt gcctggtgcc agtgagagca gggcactatt cccactgcaa ggccagacag 86101 ggcaagggga gggagctgcc tgacaagagc tgcccttacg tcaagggaca catcagccca 86161 ctagacccca tcaggaggga gccagggcct gactcccctg accttgctct ccaatcttct 86221 gcctaaaatt ccccatcagc caaacacaac tgaaaactga aagacagggg agcctgctgt 86281 taataaggtg agcttccccc agaataaagc tgggtagaga gtggagaatg gatatggaag 86341 ggcaaaagga agatttataa gacagtgggc actaaatatc tatgagatga ataaaggaac 86401 cacattttac aacaaacggt cattgaaacg ctactcaatg gaaagagatc atttcggtca 86461 ctgtctggtg cagacaaatc aaagcccaca tgcatcaaaa aggccatgtc cgtgtaactc 86521 cgacacgggg cagacaacaa ggctgaagcc tatggggtat gtggagccgg aactgagaga 86581 tcctgatgta aatctagcac ttgggaaaag ggggactaga agaaattcac ccacaggcag 86641 aggaaaacac aaacacttat ctatttttgc ctaggcttta agtggtatgg gaaaaatctc 86701 tgagactaca aatcctgtgc ttcatgcaca ggtttataat accctcaaaa tggaagaccc 86761 caaaaccagg cgcggaaaat tcatatcagg ccattgatgc cctcaatgtt cccggctgaa 86821 acaaactcaa aactcctctg gaaaggagtg ctcccacttc aagccatgaa aagctactgc 86881 agagaaaata atccccagtc aagacacact cacattgaaa ctgcaaggca cacaaggaaa 86941 tggatcacct tgagtgatag ctggcagagc taataaacct ctgtatacct ctaagaagct 87001 ccacgcacta gtataaccct taaagatttg atgaaatcat tactttatta aaattgtttt 87061 tataaaaaat caaaatccaa aaaaagcaac aaattttata ccagagccaa ttcggtatat 87121 acaagggtgt cttactcttt tggaatttgt cttattgtcc taactcagca cattgtcctg 87181 gtctatgaaa agtcctagaa acccttctac cctctgtaat gtaggagctt taactcaata 87241 gggtttttta aattcttttt tcttgtcttt ttttcttttt taattttttc cattttttca 87301 agtcaaactg aagaaatatt tttcttttct ttctaggaat gcatattcac cccccaaggc 87361 cacttgtctc ctgattggag agtattagac aattctcagg atttctttat tttccttctt 87421 tattccatag gattgggaaa cccagtagga ttgggtttag gcatatctct aaagcaccat 87481 gtttcaacgt tttgatgtaa gattgtgccc tatttcttgt tcagttgctg ccagcagatg 87541 ttatagtttt aaaactagtt tttggtcatt gagatattag aggagggaag agtctgctat 87601 cctgctttac tcatcttcat ctacactaca ctgtcatctt cactgcaaag tcctgtatta 87661 atgtttttag attctataac attttaacag gtgtcaaaaa atcttaagca ccacttcagc 87721 ttgggaatct ctaaatgtaa tggtgtttgt gggctggact gatgtctgcg tcttgttgtt 87781 gttattgtct gtagtaazgg agagccggga gatcctggac acttcctgtt catgggcact 87841 tgatgcatta gctgccccag cagctgatta catttaaaca aggatgtgtg ggtgaaccca 87901 gggagaccaa tctcagtgga atggtggggg cagaagccag gctgcagggt gtagagtagg 87961 gaatgagcag tgatgaagta gaaacagagt ttggacaact agtgaaactg cctggaagag 88021 ggggagaaga gacagtaaat ggtctgacca atgtttgagg tcaaagtggg tttgtaatct 88081 ttatttaagg gacagatctg agcatttaaa aattctgaat aatctaatag agaggaaaaa 88141 gttgggactc aaagaaaatg tgggaaaaaa tgatgaaggt taaacggaat gagatccaga 88201 gtgcaggggg agagattagc ctttggtgtt agaggagcaa ctctgtccat ggagagagga 88261 aaaatgtaga cataccacag ttgcatttga agttggggcc tgaggagttg aggagttctg 88321 agaaaagcag aagatgagat catttcctga gagtaaatgg gagtcattag aacgggggtg 88381 aagagactgg aagctttagg tagcttgaaa tagttgatgg aaaaattgga taaagtgaca 88441 atttgtcaca ctcagaacag ctatcaggga atctagaaga atctctggaa gctagttgaa 88501 gatcttaaat taccaatgta tcttgtccac atagctaagc ggttttactt atttttattt 88561 ttttgaaaca gggtctcact ctgtcacaca ggctggagtg tagtagtagt agcacaatca 88621 cagctcaatg caatctctgc ctcccgggct caagcaatcc tcccacccca gcctcccggg 88681 cctgggacta cagacacaca ccaccactcc cagctatatt ttgtacattt gtagagacag 88741 ggtctcgcca tgttgcccaa gctggtcttg aactcctggg ctcaagtaat ctgcccacct 88801 cggcctccca aagtgctggg attacaagct tgagcccggc tgctaagtgg ttttaaacag 88861 ctgttctcgg aaacacacac tcaaagaaaa aatgtagagg ataatttatc taaggctggg 88921 gcttcaagag aggtcagggt gttgacaaga gaatgactaa gtggcagact actggatctc 88981 agctagataa agagggatgt gatcgtggga ggggctgata gtcagaggct ggaaggcttg 89041 atgaacaaca catattacac aaagaataaa tggagtgaga gaaaccaaag gagtaaaagt 89101 tgtcatcaga aaagtgagaa attttattgt gagaattcag tggtaaatca atgttaacaa 89161 acctcagctg ggcactagtg gagtgaaacc gaaggccagg gagttgagtt aatgagctga 89221 gacttgggca ccagataggg gtccacatgg acaactaagc caccaggatg atgtgggaaa 89281 ctggggtgaa tagaagcccc ttatccatgt gcacaagtct tgaataaaat aggggcaacc WO 00/09525 PCT/US99/17712 EPI-109 871 89341 aggcagtcag tggatgatag cagtgaggtg gagcagagag caatgtagtt ggagaagtgg 89401 agcccacagc agtctccttt atatctagaa gggaattaat agccaaaaaa tggcaccgag 89461 gccaaggatg tcaccttctg actcccaaat ctgagacaga tgtgagaggg aaggagtatc 89521 ctcaagggac aggagatggt gcgaatgttt ttggcataaa tcaaagatgt cagggaaatt 89581 gtcagaattc aggttccaga gacacagagg aaaagcgtgg gagaaagtgg aatattggga 89641 ggtgagatta gggcagagga agcacaaatc aaagaacgag gaatagaaaa agtcatatga 89701 gctgaggagt tggccaaaca tgacagaatg ggaatatgat ggaattaagt ggctttatgt 89761 gttccaaaag gattggtcca cgcaggccac aggaaaatgg gaggtaagaa gaaagggatc 89821 gaaatgctgc aaagtgtatt acttcatggt aagcaaagga ctcaagactc tagaaaatga 89881 tgcccttcct tccaagacta tgttagtcca aatctttcaa gatacagaac ccaaggtggg 89941 gtctggcata caagaagtat aatagaggaa atgtctgtga catttgcagg actgcaaagg 90001 gagccaggag aagctgggaa agccatgaga tcacaagcag gtctgactcc aagtgaagga 90061 gatggggaat gacgcaaggt ttggctgaag catgtgccaa aggcacccat cagaggagtc 90121 cctctccaag ggatgggcct atcatagtgt ccctaatagt gtcatggagt gggagcagcc 90181 cacggagggc acagccttgg catgaacgca gacatgggtc tcagagtgca gcagctgggc 90241 ccctcagtca attaggctcc ctcagagctg gggcaggagg tgcactagac cacacagtaa 90301 tatttattta ttattaattt aattaataat attaatttat taatttaatt aataatatat 90361 ttatttattt attattacta gaccacacag tagtatttgt atgtctaagg aagcatttct 90421 cagaatatac tcactgaact tttagcctat aagtacctgt atgaaaattt taaaaggggt 90481 ttcatgatca aaacattttg ggaaacactc catacccttt cttcctcatg aaggatcata 90541 atgcctatta gtatatgaag ggctctgaga agtcctgtag taaagaaact tgctttagtt 90601 ttttagtcca gcaatttttc aaacttaaat gagcaatagc ctcccatcct tttttttaca 90661 ctttttagca tactgcggaa taaactcaac atgcattgag aaagactgct ttagggaata 90721 gtcaacacta tttcactccc agtaagtaca tataaaatct gtatttccag ggtggattat 90781 caacacagct gtattttagja aatattatct gccctcccag gtatcacagc tactaattat 90841 tgggtactga ggtggaattt tagggatcag ccaattatgg gaaagaaaat ctgggggcag 90901 gataagatgg tctccgaagc cttaaaatta tatgccatta tttacctctt tgatctacta 90961 ctcaatatca aacaactaat tcagaagaaa attgattgtt ttctaaaagt agtttttcta 91021 catttcccat taagaagcag tggtatttaa aacttataat ggctattatg tgagattatc 91081 actatcatag tttttctcta tacaaatttt ctgtaacatt ttatttgcta ataaaaatta 91141 gatagatgga ttgactaatt gataatctaa gaaagattat atttgaagaa gccatagtaa 91201 gggacagatt aaattatcat cagtctaaac attctaatac ctatttctct ttttttgaaa 91261 ttttccaaat ttgttattat gcatttaaac aataattttt tgaactttta ttttaggttc 91321 tggggtacat gtgaaagctt gttacatagg taaccttttg tcatgagggt ttgttgtaca 91381 aattatttca tcactcagct atcaagccca gtactcaata ggtatctttt ctgctcctct 91441 ccctcctccc accctccagt ctcaagtaga cctcggtgtc tgttgttccc ttctttgagt 91501 tcatgtgttc tcatcattta gctcccactt ataagtgaga atacaaggta tttggttttc 91561 tgttcctgtg ttagtttgct aagggtaata gcctccagct ccattcgtgt ttccacaaaa 91621 aaacatgatc tcgttctttt catggctgca tagtattcca tggtgtatat gtaccacact 91681 ttctttatct aatctgtcat tgatgggcat ttaggtttat tccatgtctt tgctactgtg 91741 aatagtgctg caatgaacat tcacatgcgt gtgtcttcat ggtagaatga tttatattcc 91801 tctgggtgta tacccagtaa tgggatttct gtttttagct ctttgatcta atacctattt 91861 ctcaagatca agttagatct ctaaaaaagg catcatccta gcatttcccc atcccttccc 91921 tgaactaaat ttaatgttgt gtgtatcaat cagcatacag tcaagacaga aaccacacat 91981 gaacattaaa tataatgagt tattaactta taaaagggta tgaactacta aagggggtaa 92041 ggagaatgct gaagaatgca ggaatggcag atgtagagag cagccataac ctctaagcta 92101 aggcacagca gccaaggaag gggcgaactc aaaaaatgcc ctccctcccc agctgatcca 92161 cccttgttgg agggggtgtg gctgcaaccc aatggatgcc caagaagttt gcagagttgt 92221 ggcaggttgg ggctgctgag caggaaactg cccgaagggg taccagtgag attcccaaga 92281 atgtgggcat gcctctggcg aggaagacgc tcttggagtg ccagcaaaat ttactaggaa 92341 gctacccagt agggtgccag caaaagtcag caggaagcca ctgtcgtggt gtcggcaaaa 92401 ttcactgagg agtgggcact gcagggtctc cacccagcac tggcaaatca gccaaaagaa 92461 caaaaacaaa ataaaaacaa atcccagaac cagaaagaaa aaactctgcc tcttactgcg 92521 accctcttat gccttctaca gcaactggca aaggagaaat gtttatgggg tccagctcta 92581 gactcacaaa gcagaacaca gaagagtgaa tgaagagctg aaaggcgata aatcagtaac 92641 tggagcctca catcctttgc cttttttatt gagggtcaat atattaagaa gaatatgtct 92701 gcgtcttcgg taaaattatt gctaaggtta tcacccagtg tgtgttttca acctccctga 92761 tataagaact tagtgacaag aaagaatgag acaatgatca tgaactattg gacccaacca 92821 tttgtggctt tagtgcccat cttctcagca aggctttctc tctctctctc tctctctctc 92881 tctctctctc tttttttttt tttttttttt ttttaagatg gagtctcact ctgtcaccca 92941 ggccggagtg cagtggcaca atcttggctc acggcaacct ccacctcctg ggttcgagtg 93001 attctcctgc ttcagcctcc cgagtagctg ggattacggg cacccatcgc cacccctcct 93061 ggctaatttt tgtattttta gtagagatga agttttgcca tgtcggccag gctgttctca 93121 aactcctgac ctcaagtgat ccacccacct cagcctccca aagtgctggg attacaggca 9 3181,tgagccacca cagccagctc tcagcaaggc tttttctgac tacactattt aaaatgtgat 93241 ccctgagcca ccttggcctc tcttgctgtc cttccctgct tcgccttctc catagcactt 93301 ctctcctact aatctacaat ttacttgagc tctgtgaagg tcaggatttt tgcctatttt 93361 gtccattggt gcatccccag cacctggaac agagctaggc acaggctagg cactctagaa 93421 atacttgctg aataattgaa ttaagtaaat gagtgatcta cacgtagtgg ggaatgagag 93481 tatacagtga tagttccttc gactaaaact ggggtcaaat tatagtgata aagaggaact 93541 cagaccttca gaggtaagct ttgtggacca cttgccaagg ctgcagaatg tgatgtcgtt 93601 tcacaaacaa ggaggcccta ttatggcttc agatatgaga ataataaaga gaactttcct 93661 ttcgcctcaa ctgcagcctt ctaaactctt ccttccttcc tatgtagaag tttcaaggac 93721 ctcatggcct gagtgtggat aggcagaatg ctgggaatca ggcaaaaata aaataatact 93781 gaaagtgaag gtcatgctaa tattagtaag ccagggtgat cctgaattta caaaacattt WO 00/09525 PCT/US99/17712 EPI-109 872 93841 ttctttggga aatttcacac ctcacatgat tctgtgtttt tacttaggaa atttcacatc 93901 tcacatgact ctgtgacatg cggtacatga ggtgcctgac tgctgttttt gtcctctact 93961 aatgaggaag agtgtgcgta ctcccagcgt tttgcaagtt tcaaagctg acttgacttt 94021 ccttcctttt cctggaactg atccatgagt atcgagagta aagctgcccg cacctactca 94081 ttcaagatcc tgagtgtcct gcccagctgc aggaggtgga gagacccagg aggaggggcc 94141 actgctgatc ccaggctgta gggggtggga agagtgtccc agggcaccat gacccccact 94201 cactcactca caggagaccc acacaagaga ggagagggca cttacaactt aggttcccac 94261 cagcaccaac tcctctgcca tcaaacatca ttgtgtttct ctttctgcct tgtctgtcgg 94321 cacacgtgga gttaaattta atgctcaatc acatatttgt ctgggctctt tctgtgttta 94381 tttttctctt aatagttctc tctcctccct tcctctcccc gcccctcctc ctccttcttc 94441 tttttttttt ccagagacag tgtctcgctc tgccacccag gccagagtgc agagtggcat 94501 gatcatggct caccgcagcc tccaactcct gggctcacgt gaacatccca ccttggcctc 94561 tggaatgtct gggattacag gcacttgcca ctgcatctgg ctaattttta tattgtttat 94621 agatccggga tctcactatg ttgcccaggc tggcctcaaa ctcctgggct caagcgaccc 94681 tcccacctca tacttctgag tagctggggc tgtaggaatg cgcctcagtg ccaggctagt 94741 ttcttaattt tctatttcta ttttgacagg tacaaatttt gtattcaatc ctacctcaga 94801 cacatctttg gtgggaaaag gatgtcattt aatcaatata taaattataa gcaaataggt 94861 ctgatcccca aattaggtta gtcacagctg ctgagtcgtt gacccaagag aagctcatct 94921 agattttttc attattttca agttcctctt ctcggttcgt ccttcttcca gaccatgccc 94981 tccccgtccc actctcttcc cacagcctcc cctccccaca gcctcctccc accattccaa 95041 atctgggctg ttctctcaat ttccttctct ctggactcaa acctacccta gcccccagcc 95101 tcagtttggg gttaaacttg tcctcctcac attctctccc acccaacttg atgtcgcctc 95161 tgtgtcatca ccacgggatt ttcctcctct gggttctcct tttccgagtg gggtcagctc 95221 ccccatgagt cacagcacca atcacttctg gctgcttgca aacccctttg ctttcctcag 95281 tgttgacacc cagggcagcc ctatgctcac tgccgctgag accccacctc tgcccctggc 95341 cttttcccag ctgacatcac cctgtggctt ccattttcct aaaattctct tttgaggcct 95401 cagtcttaac caaagcacac agtgcccctc aaaaatgaca ataaaaaccc aaacacaccg 95461 tgactgtcat ggcaggttcc tggtccccgt attgaatcag cgggtgggtt tctgcgaaca 95521 ctggtgagag gccgcattag agggtcagga ccctcaggtc tggactcgtg gtcaccacat 95581 accttcctcc ctgctgacag tagctggtac ctgttaccta ctcagagtgt cacatgccac 95641 aagccagagc gtcttggcag ttctcagcac cttgacatca cttccttgct accactcaga 95701 gcggcagtga cacagttccc ttatctcaga aggccagaag acggctgtca aaggtcacag 95761 ggaaatcaaa ggcggggtac agggccagag ggaggaggaa acaacttccc ggttgctttc 95821 agacgcttca gagatcctct ggaggcctgg gggagctttt gagtacttta tttcagttgg 95881 tccctgagct cggtgagtgg ggcgggtaga gccaccaggg gaatcaacag tggtttctcg 95941 tgcccctcag ggtcaggagc agtctgatca aaaggagggc atccactgtc cggggccatt 96001 cccacagctc ccggatgctg ggtctggagg ctgcgccctt cccctgcagg agctcagccc 96061 agtggtaagt catctgtgtg tcatctatgt atttaacccc ttatggccat gttgatgctg 96121 agcatggttt cacttttgca aacatttatt tatacccttc gagagaaaaa cgtctcagct 96181 gtcacaggaa gctgcttcgg ggggtgagca aactttttaa aatgcagaaa ttatgatcta 96241 cacccgtttc ttaaaagtaa gccatcgtac ttggttctct ttaattatat attttcttac 96301 atattgtgtt catgtaggca agtcctgttt ctgctaaaag aaggtaagtt ctaccaaggc 96361 ggtgtcatgc cagctttatt tcccgtggca cctggcacac tgctaagcac ttacatgctt 96421 aacaactaga ttgggaatgg tgctgctctg gggaagtggg cacacgttaa agaaatgttt 96481 atttcagtct tctgaaatag ggaattactc tggctaaaat gtagctccag aaagggaaag 96541 tggggctgta tgaatccagg tccagtttgt tgtttcctcc aggataaggc agctgtcgga 96601 ggggaaaatc atctcccatt tctccacagg gcagtctgaa gatggccaat tacacgctgg 96661 caccagagga tgaatatgat gtcctcatag aaggtgaact ggagagcgat gaggcagagc 96721 aatgtgacaa gtatgacgcc caggcactct cagcccagct ggtgccatca ctctgctctg 96781 ctgtgtttgt gatcggtgtc ctggacaatc tcctggttgt gcttatcctg gtaaaatata 96841 aaggactcaa acgcgtggaa aatatctatc ttctaaactt ggcagt-tct aacttgtgtt 96901 tcttgcttac cctgcccttc tgggctcatg ctgggggcga tcccatgtgt aaaattctca 96961 ttggactgta cttcgtgggc ctgtacagtg agacattttt caattgcctt ctgactgtgc 97021 aaaggtacct agtgtttttg cacaagggca actttttctc agccaggagg agggtgccct 97081 gtggcatcat tacaagtgtc ctggcatggg taacagccat tctggccact ttgcctgaat 97141 acgtggttta taaacctcag atggaagacc agaaatacaa gtgtgcattt agcagaactc 97201 ccttcctgcc agctgatgag acattctgga agcattttct gactttaaaa atgaacattt 97261 cggttcttgt cctcccccta tttattttta catttctcta tgtgcaaatg agaaaaacac 97321 taaggttcag ggagcagagg tatagccttt tcaagcttgt ttttgccata atggtagtct 97381 tccttctgat gtgggcgccc tacaatattg catttttcct gtccactttc aaagaacact 97441 tctccctgag tgactgcaag agcagctaca atctggacaa aagtgtzcac atcactaaac 97501 tcatcgccac cacccactgc tgcatcaacc ctctcctgta tgcgtttctt gatgggacat 97561 ttagcaaata cctctgccgc tgtttccatc tgcgtagtaa caccccactt caacccaggg 97621 ggcagtctgc acaaggcaca tcgagggaag aacctgacca ttccaccgaa gtgtaaacta 97681 gcatccacca aatgcaagaa gaataaacat ggattttcat ctttctacat tatttcatgt 97741 aaattttcta cacatttgta tacaaaatcg gatacaggaa gaaaagggag aggtgagcta 97801 acatttgcta agcactgaat ttgtctcagg caccgtgcaa ggctctttac aaacgtgagc 97861 tccttcgcct cctaccactt gtccatagtg tggataggac tagtctcatt tctctgagaa 97921 gaaaactaag gcgcggaaat ttgtctaaga tcacataact aggaagtggc agaactgatt 97981 ctccagccct ggtagcattt gctcagagcc tacgcttggt ccagaacatc aaactccaaa 98041 ccctggggac aaacgacatg aaataaatgt attttaaaac atctatttaa tgtattttaa 98101 aataatttgt aagttgattt taaaaccaat ttaactacat tccaaattat agacagccca 98161 tttatatggg agtaactttt caggctcatt gcctcgccgg tgatgagaag aactagctag 98221 ctggaagctg tgggaaaaag aggtaaggta acttgttctg tcgaagttct ctaaattctc 98281 ttgcttactt gccacacccc taggccccca gcttccccta acccaaggtt tctggtattt WO 00/09525 PCT/US99/17712 EPI-109 873 98341 tctcgtactt tatcaaaact atggaatctt aggagactta acaaaagcaa atgagaaatt 98401 atgtttagaa atgtctaaca aaatgaattc tttgtccttt taagtataac acatacctca 98461 ggcctcacca gcacataact acaaaaggtt gtcccacttc ctttctgtgg ctgagttagt 98521 agaacacagg ctcccacctg ccacatcagc agaaggtcac ctcaacatgt gagctacctc 98581 cccggagacc ccccagatcc gtaaggatga tgcatccttg atcctaaaaa cattttcctg 98641 ttcctggtgt tcagaattgg actccacact cactggtctc tttataatct tgcttctggc 98701 cctttgaggc ctcaaagcta ccagggcctt gctgccaggg gacaatcacc gctcccggct 98761 gagtcctgca gacataaggc ctgggctggc tgcctcctcc tgctggccca gcatcttgct 98821 tgcactaaag agagctggag gcttggcact gatgcttgct aaaaacctac ccaggccgcc 98881 cactgctgcc gcactgcagg gcaccagccc acactcctcc cctcctggca tcaggcacac 98941 gttcacggca ctaaacctta caggaaagca gtggaaccct gtctttcctt cacaggaggc 99001 actttccttc ctaggcaaaa acgatgatac ccatgggcac agcatctcac atagggacac 99061 atagagatgt ctgactcatt aaaacccaag tctctggcca attaaaaggg gtccttaatg 99121 tcctactcaa cagtggtgga aggaaatttg ctctatattg atgaaatgag gtggagaaaa 99181 tctgattttc caaacatgag aattctccat atgccacccc ataaccaaag accccttatt 99241 tgtgttagat gaaacattca aagagcctat taggatagcg gatgagaccc ccaagggaca 99301 tgcttataca acaataactg gctccaaacc acactccatg gcagtggctc tcaaatgcca 99361 gctcacatca caagccctgt gctaaaacac agagttctgg gccccatccc ggagtttgtg 99421 gttcaggagg tctggagtgt gacctcagaa tatgcatttc taacaaattc cccaggggat 99481 gcagatactg ctgacccaag gccctccttc tgagaaccac tgttccaggg agaagaaact 99541 cagctaagta agggtttggc tttgtgctga agacaatgtg gaatttagag ttggggtgaa 99601 ttattcagga aagtagagag gtttggagat gtgagggtgg gaagcgcagt ggagggaggc 99661 agagaggaaa tatgaagcag cgtcagttgg agagaaatta ggaagaggaa taaaatgata 99721 tatgccaggg atttcagttt tgctgagccc atgatgacag actcttctct ggcaccttat 99781 gccactcatt gagggcttgt agctggctct gctctttcag agtcataata gggctatggg 99841 tctgacctca aggtgagctg gaatgggcac aagtaataga taaaactgca agaagtcact 99901 caagggtcct tcctagaaca aaggatccct acattccaaa ggcgaatgcc ggtcactatc 99961 ataaaagaaa agaaagaaag aaactgatgg tgacatttta aatggcaatt tttctagctt 100021 ctaaaaggtt gtggagcaac tggaactttc ataccctgct ggtgggaatg taaaatggta 100081 taatcacttt ggaaaaattg gcagtgtcac caaaagcaaa gcctatacct actatccatt 100141 tcactcctca gtatttaccc aagagaaatg agcatgtatg tccatacaaa gatttggacc 100201 caaatgttca tgacagcctt atttatatag cctcaaacta gaaaaagtct gtctatcaac 100261 aggtgaatgg ataaacaaat actggcctgt gtatctaatg gaatactgct catccacaaa 100321 aagaaacgag ctattgatac acacaggagc atgcacgaaa tctcaaaatg ctgaatgaag 100381 gaggccagat tttaatttta tttttaatta tttatttatt tatttatttt tgagacagag 100441 tctcgctctg tcacccagcc tggaatgcaa tggtgtgatc ttggctgact gcaacctctg 100501 cctcctgagt tcaagcaatt ctcatgcctc agcctcccaa gtagctgtga ctacagtcat 100561 gcacaagagc aactgactaa tttttgtaat tttagtagag acggggtttt gccatgttgg 100621 ccagctgctc tcacactcct gacctcaggt gatccacctg cctcggcctc ctaaagtgct 100681 gggattacag gcatgagtca ccgtgcccag ccggaagcca gatatttttt aaaagtactt 100741 attttgtgat tctatttata taaaattcta gaaaatgcaa acaaatccat agcgacagca 100801 aatcagtggt tgctggagat gttggagggg agaggagagg aatagattgc aaaggggaac 100861 aaggaaattc ggggggacag tggatatgtc tgctattttg actgtggtga tggtttcatt 100921 ggtatataca tatgtcaaaa acgtaacaag ttgtatacgt gatttattat gtgttgacta 100981 tacctcaaaa aggctatttt ttaaaatccc cctcaggctc caggcactcc attacgttgg 101041 tgtgacttgt cttggaaata tactttgagc atttgccgga ggagatccag tgcctgggcc 101101 tctgtttctt ctcccaagta gaattggcag ctaaaacggg atgcccatgg gcacaacttg 101161 tcacccccat caccgaacag ggagcagaag gaggctgctg ggggtgcccc cacagggagc 101221 acagtctcat cgggaatgac ctgccatggc aaataaaatc accagggcaa gtcaagggag 101281 agaccaggga agagagtgat ccagtctata ttaaaaaagg atgagaaagg ttgaagaaaa 101341 agagaagaag ggacagaaat tctcttcaca catttgcaga agtaggtccg gactctccat 101401 ccacttctcc tcctccgata ggtaggacag gaatctcaga ggaaatggca tcatcttccc 101461 atgtttacag acacagcaat gaactcaaag aacaatctta tcaggatttt ccaaatgaaa 101521 acatggagca tatagagaat aaagatccat aaactcgtat ggtggctgag actgaaatgg 101581 ttaatgaaaa gcaaaagtgt gtgctgaatg acaccagcca caatggcctg aacacttaag 101641 tagtgtaata tacttggaac attgacagct aacaaggtct tcctcccatg tcagaccaag 101701 aacacagttt cctaaagata aaaatagcac atgcttttcc acttttccat aagtgactgc 101761 attagaaaac taacaaacca tgaaaagcaa aatatggcta gtctcttcaa gaaaaactgg 101821 tgtttctatt ttgtctgtaa attactttct aatacaaaaa acaattcctg ttacattgag 101881 gtaattctaa ctagggacat atgagagaga gattgaaatc tcatgagctg tctccttttc 101941 atctcaattc tgtgtactcg tgggtacaaa tggaactagt ttttgtttgt ttgtttgttt 102001 tttgagatgg agtcttgcgc tgttgcccag gctggagtgc aaaggtgtga tctcggctca 102061 ctgcaacctc tgcctcctgg gttcaagcaa ttctcctgcc tcagcctcct gaatagctga 102121 gattacaggc gcctgccacc atgcctgact aatttttttt ttgtttgtat tttttagtag 102181. agacagggtt tcaccatatt ggtcaggctg gtctcaaact cctgacctca ggtgatccac 102241 ccacctcggc ctcccaaagt gctgggatta caggcgtgag ccactgcacc tggcccggaa 102301 ctagttttaa aacaggaaac agttgatata ctgaatggaa aaacaataca atttgaagtt 102361 gaaaaaacaa aataagatgc ccagttaaat ttaaatttca gttaagcagc taatagttat 102421 ttagtataag tacaacccat atacgacaat tgcagtattt gttatttatc tgaaattcag 102481 acttacctgg gcatcctagt atcctgtttt ttgttttgtt ttgtttttcc ctttgttttc 102541 ttttttttcc ccgaaatctg accaccttaa ctttaaggta tttattcatt tttaaaaact 102601 aaatattttt cggcagtcag aactagagca aagataaatg atcccaggac tctgtttagc 102661 aggcagtcag gaagtgtgac agtgtggtgg gtggcagccc cggccaggcc tttcctcttc 102721 cctaaactgc cacagcagga ctgccacact tgggaatccc agtttccatc tgagcagccc 102781 ctccagagtt tggaaggagt cagtgcttta gcctgaggag ccgtggatgg ctctaacact WO 00/09525 PCT/US99/17712 EPI-109 874 102841 ttgcttgtcg gttgaataaa aatcaaccca aaggtggcct acactcattg aagtaggaat 102901 gccagaactt cagtggtgtc acatagaaga aaatatctaa gtgcttaggg agatggcagt 102961 gctagtggat ctactggatc attaagactc actcacccac ccagcgcagg tctagaggac 103021 acacccttgc cacactggga agtgtaaatg agctccagca tctttatttt tttttatttt 103081 ttatttgttt tattatactt taagttttag ggtacacgtg cacaaagtgc aggtttgtta 103141 catatgtata catgtgccat gttggtgtgc tgcacccatt aactcgtcat ttaacattag 103201 gtatatctcc taatgctatc cctccccccg cccccggtgt gtgatgtccc ccttcctgtg 103261 tccatgtgtt cttattgttc aattcccacc tatgagtgag aacatggggt gtttggtttt 103321 ttgtccttgt gatagtttgc tgagaatgat ggtttccagc ttcatccatg tcccgcatct 103381 ttaaaaaaaa aaaaaaatct ctaagtggtg gctcttctct gtagatcagg agctgtagtg 103441 agcaatgcta caaaactgga gtttctaaat acagggggga tggtgggatt ctgaggaagg 103501 acaggccacg tggtaacact tacaaaagac caagtgggtg tggttgccac tgtggacggt 103561 ggagccaaag cagtcctcag aatagtctga cccccagagg tctttggcat tggctggttg 103621 atcatggtgt ccctggaatt gaaatagaag gacggtctac taaattttta cctgatctgt 103681 ataagcagaa gagttctatc tctagtgaac agaagtctaa ctttagtcac cagaactgag 103741 agtcaattca atcaattccc agatttgaca tagtttatag acctagaacc ccttgaatga 103801 aaggtaagct ggctcccctt gaggaaggac cctgttacat ttccggcatt ttattctgat 103861 aatctttttt cccagccttc cccaaagcaa cttagggcca tttaccaggg aaagccatgg 103921 aggaaaagga aataattagg ctatttggag attccaggac actggctcta cgctgacacc 103981 agttctaaga gacccaaaat atctttgtgg tctaccagcc aaagtagggc ttcatagagg 104041 tcaggggtca ctagagtttg agctcaggtc tgtttcactg tgagtctaga gggtccctga 104101 acttatccta tagttattcc cccagttcca gaatgcagaa ttgagctgag agcagtggct 104161 catgcttgta gtcccaacac tctgggaggc gaaggtgaga ggatcacttg agccaagcgg 104221 tttgagacca gcctgggaaa tatagtgaga ccccatcttt taaaaagaca aagaaaaata 104281 aagaaaattg acatggaaaa ataatataaa atgtgaataa tctcacatct actaaagaaa 104341 ttcaatctgt aattagaact cctcccacag agaactataa gcccagtgcc cccatcaact 104401 ggagaaacag aaagaaacaa tcttcttaac agaaagcata attggaatag agatactctg 104461 catcggggaa gaatccccat attgattctc tgatccatag agtgaaggcc aagtggaagc 104521 ctttggaact ccctctacct gccaagatac taaacaaaac aacactgcac gtctggagga 104581 attgtagcaa gaacttgaaa gatgaaggat gatgatgtcc acctctctcc attcagctca 104641 cctatctggt ttgtgcagaa gacaaatagg tgttggaaaa tgacagtgga ccagtgtaaa 104701 cttaatcagg cgggggctcc agctgcagct gcaggatcag gtgttgtttc atttctgcag 104761 ctaatcaacc cttctcctgg cacctggtgt gcagatggca atttttcttt tctattatct 104821 gttagtaaag actatcagaa gctgtttatt ttcagttggc aaggtcagca atacactcca 104881 agggaagagc agtctgtctc agatcttacc gatgcctggg gatagggagg gagtggcccc 104941 ctcaccgtct ccaaggccta gtcctctgct cctgctactg gcagcaaatc cacgcaggtc 105001 tgcaacaacc tcaattcctg cctcctcaga agaaagaatt caattgaggg acgtaagaca 105061 gaaggagaga ctgaggcaag ttttagcaca ggagtaaaag tttatttaaa agctttagaa 105121 taggaacaaa aggaaggaaa gtacacttgg aagagggcca agtggacgac ttaaaaagca 105181 agtgcgtggt ttgacctttt gacttggggt tttatacgtc agcatgcttt cggggtcttg 105241 cgttatttct cccctggttc ttcccttggg gtgggctgtc ccatgtgcct gcctgagccc 105301 actggctcaa ctcctgagat cttataggga aactactgct caccagtttc gagtgttttc 105361 tatctattag gagccggctt ttccctgttg ccgggtgtga ccaattatta ctttagaaag 105421 acagtcaaca accgccagac catcacctga tggtcacctg acactcctgg tgtgtggggt 105481 atggggagcc ctctcctgcc ctgctctttc tgactagcta cccactataa cactcccaga 105541 gggacctgca cattttgtgc tctttgcaag acagtgcctg cccagcacct gtaggcctgc 105601 tcaccccttc agggtcatga tttttgcttt ttaccgcagg tacccataag caaaacatgg 105661 cattgttcac catgctttta cattattcac ataattttaa gttatttaca caacaatgta 105721 aaaccatggt gaaccatgcc acatgttgct tatgggtacc tgtggtaaaa atcctgctac 105781 tagctcattt tgcagtgtct ataatgacag gtaatgctcc attcactcct ttatgacact 105841 tgcaaaaact gagaacataa cgcctcccag ttaagcaggc atctgggcaa tgtgaggaga 105901 acagaaatag accacgctgc atttatctct cttgatgaca ggcattgaga tttccacttt 105961 ttctggtttc ttattatgtc tctactgggc attcttacat acatcttgca cgccatggaa 106021 agtttctcta gggcagtggt tcacaaactt tttggataca gaatactttt atgtgcttga 106081 aaactgagga ccccatacag ctttagttta tgtgggtgta aggttctagc ccaaactgaa 106141 gtccgaaggg agttggtggg tgggtgaggg gtagctgaaa aaacacccga ggaatcatag 106201 gcagtttgaa catggcctta tcctctctct gggcacgagc catatgtcca gtgtcagcag 106261 ggtaattata ccttttacag acaatagagg ctctgaagca atcacgagct cacgtgagtg 106321 gtcacctaat gcacctcaag tggcatggtt cataatgtgc ggagtcgtgt gcctacgctc 106381 caaacccact gagtcatggt gcaccaaaaa gtggcctcag cctgctcctg actaaagcgc 106441 agccatcttc cttacactcc acccctaggc caggggcatc ctccaggtag ggacatgtgc 106501 ccgtagggtg gagccctgaa tccataatcc acagcaacaa tacggagagc aacagctcat 106561 gactaggatt ccagctatgc tacttatgac tatcagggcc cagcgtaggc cagagcccag 106621 ggatgtctac catctctgca gggggtcatc agtaaggctc ttgactacct taatctcctg 106681 tgagacccct tgcagggctg ctgttatgtt ctgccaattg tcagggataa aggtacaaca 106741 ttgtgttcct aaaagggcac aggtgcctcc ttaggcagca gttactatgt ctaagaccat 106801 tcggtttcgc aacaccacct ttctgatctg atcaacctca tccattaatg ggaagagggc 106861 cactcaggtg taattcagag cctgagcagc atgctctgca agagcagtaa cttggcttct 106921 acagttgtga cacacactcc agggctagtg cctgtcaagg ggtaaaacca ccagggtgct 106981 cattacactt gcaaaaaccg agagtgtagc acctcccagt tatgcaggca tctgggcaat 107041 gtgagaacag tggcaggtac atgaggccac cctcaggtat aatgtccagt ccagtttgct 107101 tataggtaag gccaccctgt gtccccacag acccataaac tcccaggggg cacacagtcc 107161 atcgaggccc cttggtgggg ccgcgtcttc caccatacct ttggtgtggt gacatgtatt 107221 atgcttacac acactgtgac gggtacccat cccacagtgc tattacccca gtgttgctat 107281 atgcaccaca gtgcctgggc caggggtact gcacgttacc tcactagcca gccccaccca WO 00/09525 PCT/US99/17712 EPI-109 875 107341 tcataaatgc tatgggccag ccagggaatg gctgtgctgt gggtcttgtg gcatcctttg 107401 tccaaaactt gccacgttgc gttccaggca tcagccatgg gaccccaagt ctccagccat 107461 gtctggttct ctgcagatgc tgaatgtatg tgctaaggca agccatctgc agctgctaga 107521 agggcggtgc agatccaaca gttggaaaca ttggtcactt cagtgtaggt gtgggcccag 107581 tccacaatgc agttggagca tgttaaccta cagttggaat gacagagtag gcataggtac 107641 taacagagga aaatcacatc cctcaggtaa aatacaggct aacctttcat ccctggataa 107701 caatgcagcc cccaaggggt tctgccctgg gcaatagtac cacacctttt cagctcccca 107761 tggttccttt gggtcctgta ttcatgcgaa agtcacaggg gagcttgtag taggccacac 107821 agacagtaca tttgaaccct ggaggaaagt ttcttccctg gccgttttcc tacaaacagt 107881 taacttcggg gaccattcat tgaacaccca aagagtgaca tacaagtcat actgtaggcc 107941 ctccccacag ggagctacga tggacaacca ccagcagccg ggggcttgga ggggctatgg 108001 ccacagccag gttttctgtt cccctgcctt cagggacgtt ggggcaggca acaacaggtt 108061 actgttcatc cccatacctg gtcagaggcg gttacccttg gtgtgtatct gcaactgaat 108121 aggggtggtg gcccatgtaa caaagcctcc acctgggctg ggctgctttt ccatggccat 108181 tcattcaagg tttggagcat caggtccagc ctggaacttc agccctgcaa agacaggagt 108241 gtgacatgca agtaaaaccc attcttcaag agctcgctat atcactcaat catacccaca 108301 gcttgcaagt tgtgcggtac atggaatccc tactttatgt ccattgttgt gcctgttgtc 108361 cagtaaaatg tgtcccccat cactctcaat gaccaaaggg caaccatata gagcacataa 108421 gtgttgcagg gtctggatgg tgtgctgttg gttggccacc ctgcaaggat aggcaaacaa 108481 caggcctgtg gctgtgtcca cagctgttag cgcatgagta tacccttgtg acttcggcag 108541 cagcccaatg tagtctactt gccacctggt caagggcact tgccctgttg tcacttgtgt 108601 agcactggac agctgcctcc atttagggta tgcctgagca catgccgggc atttctgaca 108661 agcctcccaa atgtcttgca tgggcagaga cagaccccaa catttattga cttgttgcat 108721 cagtttaccc cctgcatgtc ccagtttccg gtgtagctac aaggccacat ctcatgtaga 108781 tgccaactct aaccatcgga ccttggccaa ggcttctgcc tcgtcattgc tgggggtggc 108841 cagaggcata tggcctgaca aatgataaat agttacatct ttgcaatgac ccatttccca 108901 gaggtcttgc gacatgggtt ggtggcccca aatgggttgg tggccaacta gccaattctg 108961 tattttccaa gtagttaaac acaaagttag gcctccatag actgcccagc tatcggtacg 109021 gattaccata ggtgtctcc g ccttgttgat caccatccat actgctttaa attcagccca 109081 ttgactactt tgtccacatc tggtttcaaa ccatatggtt ttggtactaa gttggactgc 109141 aacactggtc caagcaggag tagcacctcg actagaccca tctgtgtgcc atgccccatc 109201 aggaatagag ggatgccctt ccttaaatgg cagtggctca gggtcaaggg gtgcctcagg 109261 ccccatggcc ttctcttgca ttaggactgc aggtcccaag acctcttgca actctgctgc 109321 taatgggctt gtgctcagcg tactctgttg ctccaagtaa gtgcctcact ttgccaaagt 109381 ggatgtctgc accatcccag tctggggggt cattacacat gaatgcaccc atcccgctgt 109441 caggtaagtc atccacactg tgactgtagc ccatcctatc acttctcaca agcctgaagg 109501 gcagcatata cagctgctag ctatttctct atcaaggaat accagagctc agctcctttc 109561 catagttggg accaaaagcc tcctggcatt ctcaggcact ctgtgtgctg ccacaggccc 109621 aaactaaaac catctgtggt cacatgcata tccagttcaa atgggcaccc cttgtcaaat 109681 acccacaggg ctcgtgcctg ctgaatagcc cacttggctg ccaggaagcc agtctcagcc 109741 acatcagccc aatcccagat tgctcccttc tttgttaact gatacaatgg ttttatcatt 109801 tgagctaaat gaggcaggaa tgtccaccaa tatcccagga ggctcacaaa agtttgcagc 109861 tgcctcaccg tggtgggcca gggatatgcc taaattttgt caatgatagc ctcttgtatg 109921 gccttcatct tacccgacca gataactccc aagaatttag caggtaatcc aggccctcgg 109981 accttggatt tgttgatggc ccaactgcat gctgccaaat gttgccacaa gaggggtgcc 110041 actgcttcta aatctgcaag agaatcagag gttaacataa tatcatcaac gtaatggaac 110101 aagtggactc cctttggaca ttttcaggct gttaaatcca tggcaacaag accatgacat 110161 atggtggagc tatgcacata gccctgcagc aacactgtga aagtccattg tcatcaaggc 110221 aaactgttcc tggctctcta gagcaaggtc aactgagaag aatgcattgg ccaagtccac 110281 cacatagtgg tactgtccta attccattgt cgagtggttc atcaaatcca tgatagatgg 110341 cacagcttcc aagccatgta aaatatccac ctccagaatg tattcaggta tgggagagac 110401 atacacagtg tataagcaag gagccaagtg gccaatgcca aggtacagag atacaggttt 110461 cactttcact gactggcctc cgtaaccttt aatatatgca gatttgccca aaaacttaac 110521 tgggttccca taaacaaggc tacaatctat gccagtatct accagcacca gcacccactg 110581 tacattggtg ggggaccagt ggattgccaa ttccacatgt ggcctctggt catctggtgt 110641 ccccccaagc cagacacctt tggccagttc cctagttgaa cagaaaaggc tctacatttc 110701 cacctggctg cagcaagtag tctctgagct gggtaggacc aggtcacaca gcaatgcctt 110761 tctccccttt gggcattttg cggaattgct gccctgcata caactgtctc cgcaaagtta 110821 ggagtatttc attgggctgc ttatcaattt tctctcagtc aaccccagcc aaaatcaaat 110881 ctatccacat ctgtgagcgt gtcactcgtt ggggccccct ttttttatgg gggagccccc 110941 tgtgggtggg gtaacttccc cttctttatg gtgtggaccc tccaatcccc ctgaaggcct 111001 tctgcttccc tgagagccgc catggcagtg gttacttcat gtatgcggtg ccctacgtat 111061 ggggtgagga cagcagctag ggagccaaag gggctcagga gcatcaaacc caacatgaga 111121 tccctcatgt gggaggtgaa acatttatca tctggccctc aggtattcag gacaaacata 111181 gcctgccgca tacccatctc ccgaatgact tacaccaaat tggcatatga ctgccattta 111241 ctcacagttt tgggcatttc accagcatta ttccacacag ttcatatggc tgcctgtagc 111301 cactcagtca gggtgtggtc tccttgcgct gccactaacc acctgctcac ttgcagccgc 111361 tgacagagag aggggtgagt catggtggag gccagcttgt ccatctcaga ggtggaatgg 111421 gagataccat ctgctccctt gttccacaga cgaagcatcc aggcaggcag gggttcccct 111481 ggacactggc aacactgctt gcctaattcc tgcaactcag ttggggtaca ggcaatatac 111541 gaaatgtgtt gcattatggt ggggagtccc tgagtccacc cttggagccc cagtggctgt 111601 tcatgatcta ccttctgtca gaccaccggg tgagcccgca acaggggttc ttcctccttg 111661 gtatgaaact gagtggggat ctccagacaa gatgatggac ccaggcctgc attcatggta 111721 gcctctaatt ccttttccaa gctctgaagc cacacctcca ggcatcctgc ctgcacctgg 111781 aggtccccat tcatggcagc ctctaattat tttccagatc ggtgtagcca gacctccagt WO 00/09525 PCT/US99/17712 EPI-109 876 111841 ctgcatccct cagggactgg gtgtgtactt ttcttagcac agttaaaaat gcccatccaa 111901 ctctgccagc aaaggctctc tccttcttgg tgctctgcac ttccagctgc ttcagcgcct 111961 tctccatgct catgggggac ccatctactg ccacccaggt ttccactcaa gcccaccctc 112021 acagcacggc taccaccggg taccacaacc catgttgtgg tcacatggcc aacctggaat 112081 cagcagggac cgaaggctca cttaccttag gatcctgttc gtgatgccaa ttgtcaggtt 112141 ctagcccaaa ctaaagtcca aggggagttg gtgggtgggt ggcaggraac tggaaaaaca 112201 ctcgagtagg cggtttcgac atggctttat tctctctctg ggtgcaagcc atatgtagtg 112261 tcagcagggt aattttacct tttacagaca atagtggctt tgagccaagc acgtgctcat 112321 atgagtggtc acctaatgca cctcacatgg catggttaca taatgtgtgg agttgtgtgc 112381 ctgcctccaa acccactgag tcatgctgca ccagaaggct gcctcggcct actcctgact 112441 aaagcacaac catctccctt agagtgggct aaatctactg ctatttatac tattagaaat 112501 tttaacacag aagttttaaa tatttacatt gttaattgat tttgaaataa taagcccatt 112561 acaggttaac ataattaaca tacttttatt aaaaatatct gtatttttta aaagaaaaaa 112621 aattagcaac aacagtgatc cttggaatcg tcccacctca gcctcccaag tagctgagac 112681 cacaggcgca catcaccatg cgagctaatt tctatatttt ttggtagaga tgggatcttg 112741 ccatgctggc cagggtggtc tcgagctcct aagctcaagt gatcctcctg cctcggtctc 112801 ccaaagtgct gagattacag gtgtgagcca ccacttctgg ccagaagctg gattctctgt 112861 cttgttctcc atccaatctg ttagactgtc aaatgccaaa taacctttgg aaaattctac 112921 tcgtaaaata aggagagaga taaataactt ctgagtatca tcattaaaat agtttgacct 112981 catggaccca ctgggtccca tgtggagaat agctctaagc taaagagtag aatggctggg 113041 aggggacata aacattcagc ccatagctgc tgaccacaat aacacatttt aagtctcttc 113101 ctctcctgct ccttgtgatt gcagacagac tcaatctgta ggagagctgt agagagaaca 113161 agctcaagcc cctgattttg cctacaaaga aagctgagcc cagcaaagtt aagggactta 113221 cccaaggtca cacagccaca cagcagagct ggggctgagc tccaggtgtc ctgctacaga 113281 ggccacttct ttctcccact agggactggc ctgtgattac ttcagaaaac aatggtcagc 113341 taactgattc tgaacgccct ttgctggtaa aagctaatct cctgaggaaa aatgtatgca 113401 ttggctgggc gcagtggctc aagcctataa ttccagcatt ttgggaggtg gagacaggtg 113461 gatcacttga ggtcaggagt ttaagaccag cctggcagtc atggtgaaac cccgtctcta 113521 ctaaaactac aaatattaag ctcggcatgg tggcaggcac ctgtaatccc agctactgga 113581 gagactgagg caggagaatc gcttgaaccc aggaggcgga ggttgcagtg agccgaggtc 113641 gcaccactgc attccatcct gggcaacaga gtgagattct gtctcaaaaa ataataatag 113701 taaaataaaa ataaataaac aaataagtat gcatcacctc aggtggtcag tcagctttcc 113761 caagacccca aagcacacaa tgttctttct ggtatgagtg acatggggtt cacagcacca 113821 caaagtccat gacttttccc tcagaagtga atgcatggct aattattttg tattttttgt 113881 agacatggag ttttgccatg ttgcccacgc tgctctcaaa ttcctggact caagtaatcc 113941 acccacctca gcttcccaag gtgctgggat tacaggcatg agacaccgca tggcctgcac 114001 ctatagtccc agctatcagg aggctgaggt gggaggatca cctgaaccgg ggaagttgaa 114061 cctgcagtga actgtgatcg ctccggtgca ctccatcctg ggcaacagag tgagatcctg 114121 cctcaaaaaa aaaaaaaaag tgaacacaca tgctggggaa gaggcctgca ggcacccctg 114181 ccagttctgc accagagcac actgtagcag ccctgctgtg atgcaggaag cagctccagg 114241 tcctgcagtc tgaagcatgg agcctgaagc ctggagcccc ccatccaatg ctgcgccatg 114301 ctcaccagta tcccccagca tcagcaccga ggcaccagct gcagataaat ttctcaccta 114361 aaatgttgag agatgttgct aaactgtcct tctaagggta tgtataataa tacggtcctg 114421 ccgatactga ataagactat ctgtttcatt acatcctcac aatactgaat atcattagca 114481 acttgaattt taaattgtgc taatcaatga aaatgattgc ctaattacta gtgagttgag 114541 gttatttaac attaatactc cttctgatga aatattttgc atttatcaca ttttacataa 114601 attctctcta tataattagc actagaatgt ccgacttggt tttcattgtt cctcacctgt 114661 ttggaaacac attaagaatg agggagagaa tggatgggga ctcacctagg gatgcatgga 114721 gctggtcggc agccactctg aggccctctt aacacttccc caccacacac ttaatttccc 114781 ctggtttgtc catagataca tccaacaatt tttatgtaaa taagaaagac tcagctttca 114841 atggaaaatg gtaggttgga ttttatgact gaagtggcaa aaagaaataa gggattttat 114901 tatgggggag gtccaaaccc tggtgaaaaa cgaaattcat tgaaattgtt tgaaaattca 114961 aggattaaat cagattattt tggattcagt aggaattaga ttactttaaa gccccaggat 115021 actttattct gtagaatgca tggaaagtat agaaaagaga aacaaagagg gaaagtcatg 115081 gctaataacc tggaaggggt aaatagggag ccaaaggcct gtgggacgta accaactcag 115141 cattccactg gaggctttat gatcaaatag caagctattt atcatgaatg caggatgtgg 115201 gcaaactcac gactgctccc actgccagaa ggtttgctga gggcaatcac ttcctggcac 115261 cgagctcctt gaggttatct actgggacat ctggagaatg cagtcttgca agcctactct 115321 ggacccagca gctgacccct tcttccatgc ccctcttcct gctatctctt ttgcctaata 115381 aatatggagg gctgtgtaaa gctcagggcc cttgtccact agaggcaaac tgcccgctga 115441 ccccttcttc caaatatgct cttttgtctc atgtctttta ttcccgcttt caccccactt 115501 tgttcagtcc ccctagggcc gtgtgggtta catagtggcg ccctgaacag cgacagaatc 115561 aggtgctcta caagtggcgt ccgaacacag ggactatgag gatgtgaatg aagaagatct 115621 gctggagcag aggaattgaa attgacaagg tgaatgggga tcccgggaca agtctgccgg 115681 cagcagatat aaggtcagtg ccctaaagag gtactgggag cagtgcctta aagtagtact 115741 gggaatggga agttttctga atcagggtaa catggggcag aattggtctg ttgaagaaaa 115801 acattatgtg cagttgctta aagttttgtt gaaacaaact ggtgctcagg ttagttctca 115861 cattaactac gatgctacag gaagtcatta tgcataaccc atggtttcca caggcaggga 115921 ctcttgatgt agaaaattgg gatagagcag aaggattaaa acaggctcat caaaaaggtt 115981 ttcaagttga ttcttcagtt ttctccactt ggagtttagt tcgtactgta cttctgccat 116041 tatctccttg ttattctgcg ggacagcagg ctgaatgtaa aaatctgaaa gaatctgttg 116101 tcccacccac agctccagtt gaaaataagt aataggagag ggaggataaa aattggccta 116161 taccgccccc tccagttgca gaaacatctg taccgcctcc ttcggtggca gaaacagaga 116221 ccccaataca aagaatttta cgctctgccg ccacggctgg agagccctta ggaccttgca 116281 cttttcctat ttccgtaagt cctgatccaa ataatccaca gcagcttaat catgaacaca WO 00/09525 PCTIUS99/17712 EPI-109 877 116341 ttccactaga gtttaagttg ttaaaggaat taaaagtgag tgtggtaaat aatggcatac 116401 agagcccatt cactttagga ttgctagaat ctatgtttgg tgctatgtgt cttttaccct 116461 ttgatgtgaa acacttggca tgaacttgct tgtctgctag cgcatatctg acatggaatt 116521 taaactggca agaacagggt gcagaccagg ctagacagaa ccatgctgct ggaaatggag 116581 acattacaga ggataggcta ttgggtaatg gcccttattc tgacctggta catcaactag 116641 cactcacaaa tgctgcttat cagcagtgca cacaggctgc taaatgtgcc tgggccataa 116701 ttcctgaaga gggagtccca gtactatcat ttttacatat catgcaaggg tcacaggaac 116761 cctacgcaca atttcttgca agattacaag aggcagtgag gcatcagatt cctcatacct 116821 tggctgcaga aatgctaacc tttactctag cttttgagaa tgcaaatgca gattgtaaat 116881 gtgcactggc accggttagg tgtacaaaaa cttgggaaat tttctcagag cttgttaaga 116941 tgtagcaact gagctttatc gatctgcaat gttagctgaa gcaatggcta atttagctgt 117001 tgacaaatct aaaaagagcc aagggtcaaa ccctaaaatg ggaaaatgtt ataattgtgg 117061 aaaaactgga cattttaaaa aggaacgcca ccagatctca ggacagaaag gatcttacaa 117121 tgcttttccc cccggccccc agcggaaaga acacctggac tttgtcctcg ctatgacaaa 117181 ggaaataact cggctaatca gtgctgctca aaatttcatc agaatggcac ccccctgttg 117241 ggaaatgaga tgggggcctg tacccgggcc tcacaaacaa tgagggcatt cccaattcag 117301 acctcaaccc tgtttcaggc atgggttccc agaggcatat tgagtccctc acccgaggaa 117361 ctccaggaag tgcaggatta gatctcccag ccagagaaag ggttacataa ggtggggaag 117421 acaaacccac caagattctc actggcattt ggggaccttt accagcagga tatatgggac 117481 taattttagg caaaagccac cttaacttgc aaaggcatta ctgtagtccc agaagttgtt 117541 gactctgatt atgaaggaga aattcaagta gttttattgt cacgagatct tcgggttttt 117601 gaaccgagag aatacataat gcaattatta cttattccct gcaaattaca cccttctcca 117661 tgaaaggaga aacaaggaaa taaagggttt gggagcacag ctacacggga aatctatcta 117721 tcccgaccca tagcctctaa tagacccacc tgtgtagtac aaattaaagg aaagaaattt 117781 tatgggttta tggataccgg agctgatgtg tcagtgttac cagcaggtct ttgttcttag 117841 agctcccaag atggcggcaa gccttttgtt ctctgacctg gagttcttgg cctcacagat 117901 tccaaggaat ggatccttgg gccatgcagt gagtgtcata gctctattag aagctcttcc 117961 aaaagtcgtg ctgctatcta tggactaaaa catactcaaa caataatgac ctctggcgtt 118021 taggctcaat gctcagagct aattgcagtc attcaggttt tacagctcac agcttcagat 118081 cctgtcaaca ttgtctgtgt tcagtttatg tcgtaaatgt agccggtcac atagaaactg 118141 ctacaattaa aagtacgcta aacccagaac tgctaattta tttttaagac ttcaacaagt 118201 tatttgttct agtgcagctc cttttcatat ttctcatatt ccttctcaca cacaacttcc 118261 tgggccgcta tctctaagta atgagaaaac agacaaactg attgcctctg tgtttcagca 118321 agctcaacca tctcatgtgc ttctgcacca aaatacttcc gcccttactc acatgttcct 118381 acaggtttgt attatattat gcagtatatc cctcgagcca cacctataga aggatgtaat 118441 ccacgaggtt tggctccaaa tgaaatctgg caaatggatg ttacacacac agcaaccttt 118501 gataagctga gctatgttca tgtgactata gacacttatt ctcatatgct gcctgctaca 118561 tgccaaacag gtgagacagc tggtcatgta cagcgacact gtctgtcatc atttgctcat 118621 atggggatat ctaaacaatt aaaaactgac aatggacccg cttatactag tcatgctttt 118681 aaaaatttct tgcagctttg ggctataacc cataaaacag gaattcctta taatcctaga 118741 ggacaaggca ttatagagca ggcacatcaa acattacaat gcatgttgaa aagacaaaaa 118801 gcgggtatag gaggccaact accacctcaa taaaaactac atttagcctt atttacttta 118861 aattttttga ctcctggtat ggatggtaag actccagcag aaagacattg gcaagtgtta 118921 gaagaaaaga ggaaaattta tccaaaagtg ttatggaaat ccctggaaga aggaaaatgg 118981 aaaggtctgg tggatttact gacgtgggga agagagtatg cttgtgtttt tacaggagat 119041 ggacaagccg tgtgggtgcc ctcaaggtgt gtgcaaccat ggaacgggag actagaggaa 119101 cccagggtgg ccaaccatgg acagggtccc cccggtacga gccatgagcc agctgagcct 119161 gagtgcaaag acggagagaa ggccaactgg agtcacaaca cagttctaat gttatatttg 119221 taaagaatat cactactcaa cttacagttt gtgtttatag atatagatat agatatagat 119281 atagatatgg atatagatat agatatagtt atagatatag atagatatac actttaagtt 119341 ctagggtaca tgtgcacaac ttgcaggttt gttacatagg tatacatgtg ccatgttggt 119401 ttgctgcacc catcaactca tcatttacat taggtatttc tcctaatgct ctccctcccc 119461 cagcaccgcc tcccaacagg ccctggtatg tgatgttccc tgccctgtgt ccaagtgttc 119521 tcattgttca atttccacct atgaatgaga acatgcagtg ttttattttc tgttcctgta 119581 ttagtttgct gagaatgatg gtttccagct tcatccatgt ccctgcaaag gacatgaact 119641 catccttttt tatggctgca tagtattcca tggtgtatcc ttatgtcttt ttgacagcta 119701 agaaggacca gctccaggta aacaataccc aattgacctg taaatcttac caattatatc 119761 actgcattaa tcatagcaca ttgcaaacac ataatatctc tactttgatg attttaggcc 119821 acatccctgg gctatgtatt cctgttaatc tgtccgaggc ttgggctgcc acacctgctt 119881 tgcattttgt gaaacttctt ctaactgagc ttactcatca tgtctgtaga gccttagaca 119941 taataatttt agctattgtt tccttggtcg cactaataac ttctgttgtg atgtcctctg 120001 tagctttgca taattctatt caaacagctc agtacatgga gaactggaca cacacagccg 120061 accaagcatg gctacttcag aataaaatta acactgagtt acaaactgaa gtggtgttat 120121 gggaagtcag ggaccccaaa gagagggacc agctggagcc acagcagagg aacgtaaatt 120181.gtgaagattt catcttaata cggatattta tcagttctca aataatactt ttacaatttc 120241 ttatgcctgt ctttaatctc ttaatcctgt taccttcgta agctgaggat gtgcatcacc 120301 tcaggaccac tgttataatt gtgttaactg tacaaattga ttgtaaaacg tgtgtttgaa 120361 caatatgaaa ccagtgcacc ttgaaaaaga acagaataac ggtgattttt atggaacaag 120421 ggaagacaac cataaggtct gactgcctgc agggtcgggc aaaaagagcc atatttttct 120481 ttttgcagag agcctataaa tgaatgtgca agtaggaaac atatcgctaa attcttttcc 120541 tagcaaggaa tattaatatt aataccctcg gaaaagaatg cattcctgag gggaggtcta 120601 taaatggccg ctctgggaat gtctgtcttg tgcagttgag ataaggactg agatacgccc 120661 tggtctcctg cagaaccctc aggcttacta gagtggggaa aaactctgct gtagtaaatt 120721 tttggtcaga ccagttttct gctctcaaac cctgttttct gttaagatgt ttatcaagac 120781 aatacgtgca ccactgaaca tagaccctta tcaggagttt atgatttttc tcctgtcctg WO 00/09525 PCT/US99/17712 EPI-109 878 120841 tttcctcaag agcatgtgat ctttgttctc ctttttgccc tttgaagcat gtgatctttg 120901 tgacctactc cctgttctta caccccctcc ccttttgaaa tccttaataa aaacctgctg 120961 gttttgcggc tcaggtgggc atcacggtcc taccaatatg tgatgtcacc cctggaggcc 121021 cagctgtaaa attcttctct ttgtactctt tctctttatt tctcagccag ccgacactta 121081 tggaaaatag aacgaaccta cgtgaaatat tgggggtggg ttcccccgat atgtgatgtc 121141 acccctggtg gcccagctgt aaaattcctc tctttgtact gtctctcttt atttctcagc 121201 tggccaacac ttatggaaaa tagaaggaac ctatgttgaa atactgaggg tgggttctcc 121261 caataaagtg gtaatgttga aatccacagt tctatggtta ggggaaaagc acaaagcttg 121321 caattgcagc agcaattgca ttgtcatttt aatcacactc atatttgtgt aaccaactta 121381 gaatataacc aaagtgagta tctgtgggac gttgtgaaag cccatttgca gggagctttc 121441 acatctaaca tcacctttga tattggtgaa ttacaaaaca aaattcttga tttacatagg 121501 caaattcaag agtttctgcc ttctttagaa gactggacca aattccagca aggcctggag 121561 agcctcaatc cttggactta tctaaggcac tacattaaca tcttacatgt agttcttgga 121621 ataatattgt tttgtctctg tcttctgttc atagcctgta aaattggatg gaccaccaat 121681 cggaaaatga gagctgccca ccctggcctt acattctttc aattaattca taaacagaaa 121741 gggggatatt tagggagcct aaggctcgtg ggactgacca actcatcatt ccactggagg 121801 ctatatgata aaacagcaaa ctgtttatca tgaatgcagg atgtgggcaa actcacgact 121861 gctcccactg ccagaaggtt tgctgagggc aatcacttcc tggcaccagg ctccttgagg 121921 ttatctactg ggacatctgg agaatgcagt cttgcaagcc tactgtggac tgagcagctg 121981 atcccttctt ccacgccccc cttctcacta tctcttttgt ctaatcacta cggagggttg 122041 tgtaaagctc agggcccttg tccactagag gcaaagtgcc ccctgaccgc ttcttccaaa 122101 tatactcttt tgtctcttgt cttttattcc cacgtttgcc ccctttgttc agtttcccta 122161 ggtccatgtg ggttacatag tggcaacctg aacaatgaca gaatcaggtg ctctacagaa 122221 ataacttttt aaggaaagat ttgggactta gagaccccag gagacataca caaaaatgat 122281 aagaggatgt gcccaaacca gtcttaaagt tgtggcacag ggtgaggaag atgaagctgt 122341 tactgaacct cagagagtga ctggtgttac agcaaaagtt agcaatggcc tgaagggagg 122401 gtttctgaaa tcaaatatga atgattcccc ctcagggaac ccaaccttgg gaactactgc 122461 atggttctct gtatgggaaa atatcattaa tgcaggataa attgtgaaat atcacaggaa 122521 gcatcctgca tctagtcaat cttctgtttc tggggtggcc tgtgcagctg tgcaggcaga 122581 ggcccaacca tcctggtgag tggcacacag ggactgagat ccagccacac ctaccaggcc 122641 atgctctggg aagggggtgg gacctgggca aaggacacct ctctaggact gcacagaagc 122701 ctttgtgggt gggtgggaca ttcctgtgat ggccttctgg ctgggcacta tgaaatgctc 122761 tgaagatttt tccttgcact gttgcactaa ccccagtcct ctatcactgc cccttcctcc 122821 tgggcgactt cactgatgtt gtggccatgt gaattctctg gccaatgaaa tgataaagat 122881 gatatggcct ctgccaagca gacactgtaa gtattattgt atgatgcttt tgtctctttt 122941 tttaaagtta aagcagttta ttaagaaaat aaaggaataa aagaatagca ctccataggc 123001 agagcagctg cctctgtctc ttatattttc ccctctgcct caagcccaac atgcccaaaa 123061 ttggggctgc tggttcagcc tgggtctcag aataaagaca tgagccacag atccattgct 123121 gacccatgat ggagatggac acaagagaga aacacatttt tgtcatgtta gccactaaga 123181 ttttgatttg gaggccattt gctacagcaa tataacctag cgtgaacaga gagacacagc 123241 gatgttccat ttcttttcaa cctggaacag gagaatttca taggtgggcc tcaatttcac 123301 tttagtatct tatttagaca agaaagttca tactgttcaa atgtcatgtt taagagtgct 123361 ggcattatca ctgctgtggc taccccatca gatgttgctc actgactaat cttctcatgt 123421 tagtgaggat ggacaacata tcaggccata attcaaagta gcaaatagga aaagagcttc 123481 atcctagcat tatgggacct taattaatgt cctttcctga caggtttcag aggcttttgc 123541 aggcagcagc agagctattc atctcactga cagtggggaa catggccaaa tggttgcccc 123601 cacaatggag gcagagtttc aggacacttg tctgatctct gcccttgaag gaacagtctc 123661 accctgattg acacttttgc ctgttatgtc caaagaacca atggaaaagc aggaaaatta 123721 ttccttcttc atttctctct tcattattta aaattattct gtcttcactt ctctctcctt 123781 ttctctgctt cctacttagc tctttagaaa tgcaattata atcttttatc tccccttcac 123841 cagacactcc caacagggca agttcatcta actatgtgct cttagttaga cgctacagag 123901 cagaactctc tcccaccaag agactacctt gagacataac agtcaattca caagccaaaa 123961 tatgcccgct atgaaactct cccatctgga aattttttgg ctgcttttac aacctagttt 124021 tgcccacaaa ggcaccagca gtaaccaact caactgcctg gtagacaagg caccaaagcc 124081 agtacccaga ccctctacct gctcacttcc tgccttgcat gccacgcccc ccatttaaaa 124141 gcctctgctt tctgctccaa aggtgaagca gttaccctta aggaaagaag cctgtacttc 124201 ttcccctaag gtagctttgg aataaaagtc actttatacc aaacctagct cttgttaatt 124261 agactctgca agtgatgagc aactgaacct acatttcagt tataattcct atgcttgttc 124321 ttcctgccct gccttgggga cacgcacaca ctcccaggca catacatgca cgtgcactga 124381 gacagctatg tgaataacca acaagatccc cttaggaaaa ccggtgcttg gcctggcctt 124441 aaattccaga cccttgggca tcatacccaa gactgcaaga aagaggaggg gctggacctg 124501 aaaaacttgg aagggaaggt ccaactgtac aggtattttg tcaggcatgt gatttcagta 124561 taaaattcta gaaaagatga gtgacacttt ataaggagag aatatcaaca aaatttctca 124621 ttttacttct tgctaagacg acagcaggga attgtaagca gatggatggg caatccccac 124681 cttcagcagg ggaggccaag gccccaacac acctggggag aagagctggg ggcagtgaat 124741 ggctgaggct ttcttgggga gctgggccat cttcttcggt tttacttcct gaggaattca 124801 caggcttcca ggagggctgt gggacacaac agagcaagag attcagaaac tgatttcttc 124861 cattaaacca gttatttaat ccaataaatc aaagagaata ctaagagttt tctctgccct 124921 tctcccatca ctgagtcagt gcttgccaca ctcatattcc cactccccta ctcctagcga 124981 ctacggtgtt caagggagcc agagtctagc cctcaccagc cagggtgttt ccctgctctg 125041 gcctgagaga cacaaccacc ctgcacttgt ctctgattga atcgactgtc acattctcaa 125101 gttcacaaga cattggtggt cctctagctt ctcccggaat gtgaacctgt ttgcaatcat 125161 gttcacctgc agattcactc attcattcac agatccttac tgagcacctg ctttgtgtga 125221 gttgctgtgc taagtgctgg ggacacagca tggatagact ggcctgccct caagaagcat 125281 gtggtctatg cagtcctgag ctggctgctc acaagaagag ccctgtagcc atatttctca WO 00/09525 PCTIUS99/17712 EPI-109 879 125341 gagggtggtc ctgacctaca tcacagtgac ctgagttgtt tgtcaataca gaaaagggtt 125401 tctcaacctt ggcactatg acatttgggg cctgataata accctttatt gcagggggct 125461 ggctgtgctt tgtttagtag catccctggc ctctacctat ttgttaccag cagcaccctc 125521 tatgttgtaa gaatcaaaaa aatgcttctc acattgtcaa atatcccctc aggggaaaaa 125581 ttgtctctca ttgaaaacta ccgataaaga catttctggc cctgccccca tccttggacc 125641 aacagcatcc ctaatgcccc caactctggg tgagggacca ggaataggaa tctgaatgat 125701 tgcagtgcac agggagctgt gcacactgaa atcccacagt tatcaccggg agccttacaa 125761 tactctgtga tgtcttctaa atatttttaa gggattaaat taatatcaac atatttccct 125821 ggttaagatg tgttttccta cacttgaatt tttttgagat tttgttttct ctatagttgg 125881 catctatggt aactgtc-ag aatcagattt tttttttttt ttttttgagg aagggtcttt 125941 cggtgtcacc taggctgtag tgcagtggta caatcatagc tcactgcagc ttcaaccttc 126001 tgggatcaag caatcctcct atttcagcct ctcaagtagc tgggactaga ggtgcttgac 126061 accacaccag gctaattttc aaaattattt ttgtagaaca aggtctctct gtgttggcca 126121 cattggtctc aaactcccgg gctcaagcca tcctcccacc tctgcttccc aaggtggtgg 126181 gatgacaggt gtgagccatc acacctggct ggttttgtca tttctcaatg catatgtata 126241 tatgcacctt tcattttact gaataaaatg gattatcagt ttccaaagat ttcatgacag 126301 tgccgtcact atccgtacta taaaatttat aaaaatttat tacatactgc tctattttat 126361 tctctaatta ttttatcaat gagattataa tttcctgaac tgtaaagaga tattatcttt 126421 ccttaacatt tttacacctg tgttcgttcc tagaatgctg tttggccctc aaaccttgac 126481 cttcacccat ggtggtttct cggggatgct agctagggtc tacttacggg aggttgagca 126541 ctttttcaga ttagtaatgc ctgcgacata ctgtggtccc aaatattttt catatgttgt 126601 tttgccatgg agtctggcca gacactcagt gttgtcattg aacagaaggt ttttggtttc 126661 agactggaat aagcaaaact tgtccgggca gtcagatcca tttctcccaa atttagcctg 126721 cgacaaaagg gcagacagtg agtagctaag gaaaagagga atttgtgggt taaaggaggc 126781 aaaggggtat ttcttccacc caagaacagc cctgagaaaa ccatggggca gaaggagctg 126841 agttctggag tcattccacc tccttagtgg agtcccccac cccacactcc tggtggcagg 126901 cccgccttgg gcagcatcca ggcctcacac cacttctggt cctacctcct accatctgcc 126961 atctttcctt ccttcttaac ctgtgacctt ttcccataca acttcttatg ggtgacaagg 127021 caacaatgga ggggttttga gatctgccct cacaagtcaa ttgctcagga cattctaata 127081 tgcagctctt ctagagaggc aggctgctag gaaaacccag gctcagccac taaccagctc 127141 agtgtgcagg tcggtcaccc tgcctccctc acacagttcc tgctctgtcc caggctccca 127201 tgtggggaga ctgagaccca aacccctcag tcacggcagc tctctcacca gcaccactgt 127261 gtgtgcacat taagagctcc ataaaggcca gttatggtgg ccagtcttgt tattcctgag 127321 ttgttttctt caaaagcaca cagagacatg atgttatatg ataaaaatag aagttctaat 127381 aaaatcccag attttaagaa aattttggga tttcgttcaa atcacattta gagagcccta 127441 aatctatagg gcaccttctg agtttgctgt tttagaggcc tggtctagag cactgttcac 127501 tcggcccagg ttcaggaaat gtcacctgag taaaaagcac tatactaatg catgtgggag 127561 gaaggctcag tggcttcctc atttgccaga agaacagcag gagggaaaaa gacagcctct 127621 gagccaggca gtgatggcaa caaggccagg gcacagagtc tcagcagaaa tggagtgagt 127681 cccagaaagc ccagagtcaa aagcctctgt tgttcttgtt gacactctgg gcaacgccac 127741 agcatgaagc caatactctc accatgagct tcaagtagag gactagagag gatcgagtgg 127801 gctggtgcac ctagctctgt gatctcctca cctaacatga gcccacacag ctaagaaagc 127861 actagaagcc ctgtggcca tacctgttgg tggagcaaca cctgtttcag gcgttccacc 127921 ttatccatcc gagacaccac ggcatgattc ggggccatgg caagatggca gcttctagcc 127981 tcagtcacag gcttccgttt gccatcgagg cacagcagcg caaagtctgc cagcttcaaa 128041 tccttagccc atgcgtcatt gttatttcct ggggagaaaa agaaggtggc atcatccacg 128101 cctcccctgc ttagccaaga agtctcttct gggtgggtgt ggccattcca ctgacctccc 128161 aaatgcacac actggggttg tggtgatgtg aggaacagag aaggagcttc atcctacaca 128221 agctgtacaa acttcaaata taccaaatat tagtgctgtg tccatgcaat ggaatgttat 128281 tcagcaataa aagggagtga agttctggta catcctgcaa tatgcatgaa cctcgaaaac 128341 gatgctaagt gaaagaagcc agtcacaaaa gaccacacaa taggctgggc acggtggctc 128401 atgcctgtaa tcccagccct ttggaggcca aggtgggaga atcacttgaa gctaggagtt 128461 catgaccagc ttgggcaaca tagcaagacc tcatctcaaa aaaaaaaacc caccacatat 128521 tatatgactc catttatatg aaatgtccag aataggccag cctatggaga cagaaagtgg 128581 attgatggtt gccaatgctg aagaaggata gggcaatgac tgataatagg tgcaagggtt 128641 tctttatggg aggatacaag cgttctagag ttggattgtg ttgatggctg cacaactctg 128701 tgaatgtgct ggagatcact gaattgtaca ctttgcatgg gtggattttt tagtatatga 128761 attctacctc aataaagctg tttagagttc ttattttttt aaagaagaaa accctccacc 128821 tatgccatat ttttcagga gttccagaaa aagaatagat ggtttacatt caaggagaaa 128881 ttggtttctc ctcccttca tattcaaatg ctattagtgt aaccagagaa aggaaaggaa 128941 cttttatagg tttatcaaat atatacagcc aattctaaca aaatacagtt gtaaagtacc 129001 ggagaaagtt aaaattaaat ttgacatcaa tctgatccct ggagattact tcagttaatg 129061 gcttgtaaat tctaaatgta attgtatgca tgtctatgtt tgtgcagatg ccggctcatt 129121 gttccggctc ccgtttgtct ctctgctctc tccctttaag aaagcacttt attcattctc 129181 ttggattcct ctatttgata ttgaaataat ttcaaattta catgtcttgt tttaatctct 129241 gtcccaagag acactagaag gagcagaagc agaagggaga agtggctgag actgcagtga 129301 ttactgaagg agggaggccg aaagtggaga cagttctttc tcaggaaaca gaatagcaag 129361 tcacctgctg agacttgggg gttggaatgc tgaagtgggg ctaaggagac agatgcagat 129421 tggaaggtag caaatggctg aggaccagga gagagagtga ttgttcaaac attggctgga 129481 agattatctt ccatcatctg caaccacctg taattttgtt cccactaact cccaaggagt 129541 ctccagacca aggctcacat ggggatgaat gaaggcctct acttcctttt tcataaaggg 129601 aggcttcatt tgcatatgtt cacccagttt gtagcatcat ccacagtttc caataggcat 129661 gcatgatctc atgtgggcag acagtgtgtt tctgtggttg actagaggaa gccagggaga 129721 catttgctac tgagcatggc tagtatctgt gcgtgtgaga gcgagtgtgt gtgtgtgtgt 129781 gtgagagaaa gagagagagt gtgtgtgtat gaatttcgtt tcaaaatcca tatgacacct WO 00/09525 PCT/US99/17712 EPI-109 880 129841 acagatgtta tcatgttgtc tattgagata aagaattttg gagttctttt aatcacaaat 129901 atggaaaatg ttataaaacc ttcccaaagg caaatctgaa cactaagatg tgttgtgatg 129961 ccaaagactc tgctttgaag gagaaaagga aacaccttca cctaccatca gtgttctgca 130021 agacagtgac atctttcaca aatgcaacgt ctccagcatt ctcagccagg cacctaaaat 130081 gttccagaaa atatacacat aattacagaa gagaaactag tggggctttc ataaatattt 130141 gtaatatgca ttccaaaaac tgaaatatgg aagtaaacat ctaaaagaca actatttcta 130201 ggaatttact gtttacagcg gcagattgaa cacaggtgta cctgccctcc ttttaaaacc 130261 ctatataaaa gacattacaa aaccaagaaa tctaaagata tgcgacccag gaaacaggca 130321 atctaacatq aagtaaaaca aaggaaagca ccaaaataat ggtcaacagg acccccagga 130381 ccacagatgt gcaggcggcc tacacagcaa ccagtccaaa ctgcagcagg aagatggatg 130441 ccttctggag cagcactcc aagtaaatga tgaaactgtg atagcaccca gagagagaga 130501 gagagagaga gagagagaga gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt 130561 gtgtgtgtgt atgcatgttg ttaggagatt tacattactg gcagacagtt tggggatgag 130621 atagtgatgt gtttttttaa gtgcagaaaa ttaagcaaat aagaaaagac atttatgaac 130681 tccagagtaa acaaaaagtt tgtacaataa gggaaatata atatgagaat aacgcttaca 130741 cagtcataag tactgaatat gacattagcg tgttgggtgc tgaagagagt tgaagtctgt 130801 ggttgtgtgg tggaaaaggt gctgggggca gtgtgagagg ctagatcttc ttctatacta 130861 cagagtcagc agaaagttaa aaattaagaa ccagcattat aaggatgata gaaataaagg 130921 ggtatgacac tggtttcagc ttttaatgat tttgctataa atttccccaa tctagattct 130981 agatataatt taaacaaaag acaagggatt ttcttccagt ataattagga atattaaaat 131041 gtgggtgttt ccagtgaact aataccttgc tgcaggtctg aaaaaaaaaa aaagaggagc 131101 acatgcttct ttcgggctct tatgagacat gtgttcagca tttctgagta gaatcacatt 131161 tccatttgca aatccttagt cccttaaaga tatttttaa cattcacaaa acattttttt 131221 ttgttttggg tcttttttta tgagccactt atatagcaaa agctactttt ctgtcatcc 131281 attactggaa caaggctgtt gaatttatat taaaaagttc agacaccctc agacacatga 131341 cgccatctgg tcgtgaaatg tactcttggc aaatggagga aaaggaacag gggaagatcc 131401 tctctgcacc cttcacactg gtaaatagtg cccctgagaa gcaacacccg gatgaatggt 131461 gctgtaaaac gtggggtatg gttacaagtc actaagtggt tataacttat gaattctgaa 131521 aacttgtttt ttggcttatt tttcacttcg ttactggaga ataacactgc aattctgcca 131581 tctctttgcc atttctaagg ccaaagtcag agaaaaaggg aaacctaagc catagtcatg 131641 acctaggtga gaagaaaagg ggcggcgatg ggaaagagaa ttcttcccca taaatggaat 131701 tgtaggaagc acttaggata ccacactcta cccatttgat tttcaggacg aggctattga 131761 ggcctactgc tgttgatctt ggctcaaagc cacagggaga agcactgcgg agctgaggtc 131821 agacagccct ggtgccagcc tccactctct ggggcggtgg gtgtggtggg gacagccctc 131881 actggggcca cccatgagct gacccacagg atgaccccca ctctgctgtg acaggtcaca 131941 tctggctcct tagaactgca atgctgacat gctgagggat gaggtaagtc cccatcctga 132001 tggagctcag tcacagactc accggaaagc cccagtgtag ccgtagtatc tctcgttgct 132061 gttgggcacg cacttattct caccctgctc gtcgccaata cacagagcac agagattaga 132121 tctcgggtca gacccagggg cacagctttg actgaaatat tcatctggag agaaggaaca 132181 cggggagtca gctcttcaaa cctgagtcca cacaagcaac ctttacctaa cagccgatgc 132241 agggtggttt cagttcatta gacttcccag gacagcaatc tagatagaac acactcacca 132301 tcacaaagca acatgttgtc accaacatag gaccaaccag aaaagcttca ttcagactgt 132361 aggcacagat ggacacccaa ctaaggctgg ggatgagagc tgtggctgcc tggagggtcc 132421 cgtcatcaca gccttgagct ggggactcag ctcatgaccg tgatggctgt gtgcagcaga 132481 gcctgtgagt tgcctagtcc aggatctgat tttgttttta tcagtaatgg aaaccctgct 132541 ttgtatctgg gtgcttggcc ctttggtata aagactagac ttatcagact ccctggggct 132601 catatggcca tatgggagc tataggccag tgaaatatca gcaggagtgt tgggcgccag 132661 cttctcagaa acatccttga aagacaattg gtacatgcct tttgcccttt cttctccttc 132721 tctttcttca tcctgcacat agaatgcaga agcagggact ggacttagag atgcaatgtg 132781 ggccatgagg tgaccttgag catgaaagcc acacaaatgg cagagtagcc aaatgattaa 132841 agcccaggtt ccagacccca tattgtcttc ataccagccc taggcaaacc acctctggac 132901 tacatgacac agaaattaac ttctgtcttg tttaagcctc tactatttca ggagttttct 132961 gttccttgca gctgaacctg atctgaattc gttcattgtg tgatttaacc caagaaagaa 133021 taaacaaagg tgacaagaaa gctctgcccc actgagcaaa cgtcacccat tatcagactc 133081 ccactgctgc tggaagagcc acactatgtg tcaacctcag gaaaagctgg gagttcccat 133141 tccatcctgg cagtttccct acagctcaga ggctgccatg gagctggtga ggagcagagc 133201 cacgtgaaag ctgcctgccc cggccaggat caaaaaccca tgcagtggag cccctgccct 133261 aggagacgcc catacaagaa gggagtcaca ttgaggatgt gctacacacc atgccacggg 133321 gcccacagca ggcagggtgt ggctgatgct gactaggatg agtgtggggt gtggtgggga 133381 gagaaaactg cagaagcagg tggagccagg ctcttgaggg cttattcagg ctccgttgca 133441 gtgtagagta agcgtcagtt ttgcttagta acaggagca cctttcatga ggcaggcaga 133501 catctttccc caagctggga agccagagtt taagaggaat ttcaggtcgg agctccaaga 133561 ggtaaaaagc atttgcacat cttggaactt gcatttattc ttagggtgca gcgaaatagg 133621 cagatattcc aatctttaat ctcggggtgg ggtgaatggg gcatgggaag tgctgtgcag 133681 ggaaaccccc agtgcaccca cgccccagg gggcagccac agggagaatt tccttatgct 133741 ggaagaggcc tgcaggccac tatcagcctg caaatcccct cccctccctt ccctaaggtt 133801 ccacagcaca atatgccrac cctccagggt ggcccaccca ccgcaccttt ggaactcctt 133861 accaaatttg caggagcccg tctggctgaa gagcaggccc atggggatat tccagcctgc 133921 agtcctgtcc acggcggcgt ggcaggactt cttgcctttc acagagttcc aggtaaggct 133981 agtgtctgat ctcctaacca ccgccacagc aagatatcct ggcataacag atgacagaaa 134041 aacaagtctt aacctccagg aggcctggca catggatcc agtggagctg tctacagccc 134101 aggccaaaac aggccaagaa gcaacaccag gcaatgattc cctcaaagaa ctggcctttt 134161 taggtagacc gagaaagcat aagctgctgc cttatgtaa ggtgagattg atgaaataaa 134221 acagtaagaa aagctgatta ttttagtgat tacaggggac tgtcttcaac cagccacaca WO 00/09525 PCT/US99/17712 EPI-109 881 134281 atgtccctga gttacaaacc agcaatgcat ctctcagtgt aagctrztac agcaacaaac 134341 actataaaca acaagagaga ccccaacagt gcataaatca ccaaccacag tgtgcatcag 134401 gcaagagcac caacatccag ccagctaacg gctgtgtggg tacaggggca catgtcccca 134461 gggactgccc tgagctgagt ctgaacccac cctgcactgg ttgaactcaa catggttgcc 134521 gttgtcctcc zgagagaatg catctgacag acacccacca agggcaagtc ttttctgaaa 134581 ctgagcaagc accagctctg gtgggcagga ggagtggtgc acagagcact gggacacgag 134641 tcccaggtca cgaggacccg gggtcaagac caggatctac cacagtatta cctatggctg 134701 tgagtgagat cctgggcact tggggactct cggtgccact gtttcctcat ccccatgagg 134761 tggggaagta gcacccccca ttccatgacc atgacaaaat gagggactat atggatgttc 134821 tttgccaagt gtgaaggtca atataaacat taattagaac tattcctctg tgaattattt 134881 gcacccttaa aattattgct cctagaagcc ctatagcttc tagggctgca attctttctg 134941 ttttttttac agttcctgcc acttcctctt ccagcaacaa gaacttatcc ttgaccctga 135001 aagtggctaa tgccaactca ccttccacag gtctatccac acagttagga tcagggtcac 135061 tgctttgttg ggattctgaa agaataaaga caagccagac atcattatcc attcagatgt 135121 agtgagaagc cacaaactct taaatctcaa tgatgcagaa tcaaatccaa agagaccgtc 135181 ccagcagttc catgcaggag aaatgcgtct atatgttcaa caaaaaacat ggcacagaga 135241 ttcacagctg cattattcac cacagccacc aactggaaac tactcaaatg cccatccaca 135301 ctcaaatgat gaataatcac agtagactca cacagcgacg agactgaaca gtctacaact 135361 acacacttag gtggatgaaa agcataacga tgagcaagag aaaccagaca taaaaaaaca 135421 catgctgtgt aattccttta acatgaagtt taaaacatag gcaaacttag atctgcgacc 135481 ttagaagcca ggagagaggc ttcccttgca ggagtaaggg ggcgggggac aggaggacat 135541 aaggggcttc tgaaacttgc agtgtttgtt ctgggcccga gagcatggac tgtacagtgt 135601 gtgaagtgcc atgagttgta catttatgtg cacttttctg tttgtatgtt ataattcact 135661 gagatcttct ggaaaattaa gaagataaaa ccaacctgtc ccttgttaat tctcaacaca 135721 ataggctttg tgggtaacac ggcccctttc atttcttctt tccctgattc tcccttttga 135781 atgtatctgt tcatcataat gtttcacctg cattcaccga atgggattac tcatagcccc 135841 actcccatga cccagaggga atataccaga ggatgctaac tccacttact gtagttctct 135901 gccaggacag gcaccaaacc acatttgcct gcagtgtaca catatcctcc atccaaactc 135961 atggcatcag cttctccttt ctgcaaagac agagcagatc tccagcacca cagtgaggct 136021 gcatcccgtc ctgcctgtct atatagctct ctgagagaat ggttttctgt caggtgacca 136081 gtgaaacagc agaaagagat ggactattca aactgagcag ccagaggaaa caccgtgtgc 136141 accactaatt ctctcccagc cctgcctact ttctgggctg tcaattcaac tggaaagacc 136201 aggcacaggt tgcactaatc ctctgtcctc tgagcaaaac cttttctgtg tccctggcac 136261 tttggggaca ccttcctgga gcagtctcac tgactgagga cacagatggg aacagctggc 136321 ctcatctaat ctgaactcat tagcactcca ctccaagcgc tacacagaag ttgtccaaca 136381 cataagctga agtcgtcata ttggcccacc accagaatga acaagtccag gctacaacac 136441 aggatcatgg actcatcagt agtatgaaac ttcctctttg acccagtaat atttttacaa 136501 ctatattaaa aatagagaag tggacaaaga tttctactca agaatgctca ccacagggtt 136561 attgataata gcaaagtaag ggacaaagag gaatgggggc atgactaaac tgagccatat 136621 tcacataaaa gatatcctgg aagcatgttt aaaaaatgtt ttcgtccgag tgctgtggct 136681 cacacccgta atcccagcac tttgggaggc cgaagcagga agattacttg agcccaggag 136741 ttcgagacga gcctgggcaa caaagcgaga ccctgtcgct acaataataa taataataat 136801 tatgcaggtg tggtggcgta tgcctgtagc cccagctact tgggaagctg agatgggagg 136861 atcacttgag cccaagagtt ccaggctgca gtgagatgtg gtcgcaccac tgcactccag 136921 cctgggtgac agatcaagaa tctgtctctt aaaaaaaaaa aaattaatgc tttccaagag 136981 taaatattca tgtggaagaa tgcccattat acgctgttta gtgaaaaggg cttaaaaacg 137041 acatactgca acacttcatt attgttgcat gcatatctgc agatgtgcag agaaatactg 137101 gaatggagaa :tagccagac tttaaccatg tctgtccctc tgtgtgagat cacaggtggt 137161 ttggggggtt zgttgttgtt ttgttttaac ataatacctt tccatatttt ccaaattcct 137221 tataataatc ctgagttgtt cttataacca gaggagtggg aaacccacag taaactgctt 137281 tttgaaacta aaatgctttc tggccctgag cacacctctc caggcatccc tgcctcaccc 137341 aggcccccgt ggcctctttg actgttgact tcactttaag cagatgccca ggccctaggt 137401 cttccaccgg gcccaccgcc cgcccctgtg atggagctcc ctaccagcac cagggcgatg 137461 cagtcctctg tggtggaggc cgaggagcag gtcacgctgc cttcgctcaa gccactccac 137521 tggttacact tgcgcagctc ctgctcgccc accgcacacc acacgacccg cgcacgccgg 137581 gcagccactt cctcctcacc tgccagaggg aagaccgcag gtggctgggc aacctgagct 137641 ttgccaggtt atccaacctc cccagagcca gggtcctgcc cagactctcc ctggaacagg 137701 agctacagta catgtgtgga catgtggacc cataccctct cctcctccac ttctcagctc 137761 caagcccctt cttcaggtcc acagagctcc ctgtgtttcc cacttctgtt cctttggaga 137821 agttccctgg cttctaatct atccattaat ctttagagtc aggaggcgcc tattgtctct 137881 gtctctgagg ataaacgctc catgacccag agaccagtga cagtcccaag agatggccta 137941 ggggaccttg agcccaaccc tgacttcccc taacgcctgc aatcaccacc aataactacg 138001 gtgcagcctc tgggttcccc cagactccca cccccagccc cccagtagag aaggagccat 138061 agctgagttc ccccaccatg gtgtccccaa ctaagttcaa ggtctgggcc tgggaagtgt 138121 gggtaaatcc aggcccccgg attcatccag gaggggtcct ggctatcttt gttcatgttc 138181 atgtttctca cttaatagga ggcaaactga tttttctgcc aggcctgggg agcctgacgt 138241 gcactgatca ggtggccaga ctattctttt agagacacct gacctaatcc acagaagaca 138301 ctcacacctg catcaaacct ccacgatgac cccacagtgt ctgggaaaag gagtgaccgc 138361 cacaaagtag ggccacctgc tgggaagtag aagaccacac caggcggacc tcaggaccct 138421 cctgggctca ctcacttttc ctcaagttct ggatggcagt gaagtagccg gagccaaggt 138481 acagcccaga atctatcctc gggggcaccc tcgaaaaccc aatggcagag tccttgaaca 138541 gcagatcttt ctgcccacta ggggagccaa agagctggaa tttcggtgac ttgtcctttc 138601 caaacttttc craattaaga aaaaatagaa ttatggtgtc aatggtaaat agggaggaaa 138661 caaaaaaatg atgttaaaaa agagtatctg gagctttggg atcattctaa ctgagagcag 138721 gagcctcggt tgagaccctc ctgcagaggg acttgtgcca tctcggagac ccaagctcag WO 00/09525 PCT/US99/17712 EPI-109 882 138781 ctatggctca ttctttgaag agttgctgag gtccaagcac cttagggccc tgagaagatt 138841 gcatcgacca ccccctgctt ctgctcccat cataagacgc tgtcagcccg tgtgacagaa 138901 gagtttcatt gcttctgctg tccacagtac agcctgggca agcagcccaa tgcattagtg 138961 tgctatcctg cagcaaagct acaggacttc tggagtggca gaagtcaggg aagtaagaaa 139021 ccttgctccc tgccccccat atccaagcaa gtggggagga ccgtgggtga agatacctgt 139081 gcctggcgga gaagattcca gatggcatcc tccttgccat tcacacttcg tgccacaacg 139141 gcatgagaag ggacccgggc cagatggcag tctttgaact tgtccactgg cttccgagtg 139201 ttgtctgggc agagtaactc atactcgtcc ctttcagcct cgtctgacag gtcctctgca 139261 gggaaggtga ggtgggaggg agtctagata agccgactcc agcagtaacc tcgagctata 139321 gttccccttc tccctataga attttgagct tggggagata gctgacaaaa ctgagggtca 139381 gaaaggcagg ggtttgctcc agaacactca gaaaggtaaa ggtagtgccc caaaagcctc 139441 agggggcagc cgaggtgtga tcctcatcct aaatcactta ggccaccctg gggttcccgt 139501 gcagctgctg cctggcaggc cagagaggcc aaaccagacc cgtctgtttc tgcggcatct 139561 ctgcctggaa aagtcacttt gcagagacaa gctcaggggg ccaccaaggg ttgctccctt 139621 actcacatct ctgggaagaa taaaaatgac aaaaatgtta acaaggcagg gaataaggca 139681 ggaaggtgag acactttcca acactgagta tatcaaaaga aggggaagaa tggttttatg 139741 aatgagttca ggcaaatgtg gaatatcata tataagttgc ttcagaatgt gtaaagtgaa 139801 aaaaatcttg cccgagtcat tttatgagat tagtacaacc ttgatgtcaa aatcagaaaa 139861 agtataggag ggaagaatta aaagtttatt ttacttacga acataaatgc aaaatttgta 139921 aataacgtac taactaactc aatctcacag agtatttaaa aagctaatag attggaatga 139981 aggtttacca gtgtattcca ttaacaaaag aatggctgaa catcaaaaaa actaaagtaa 140041 tctgcattta atggcagaaa accatgagat cgtcttcatc ttaatagatg cagaacgatt 140101 gtttatgtgt tcaacatcta tttgtgtgtg gttttttttt cagcctcaga aaaatagtaa 140161 tagatagaat cggtaaagtt tttttgtttg ttttgagacg gagtctcact ctgttgccca 140221 gcctggaatg cagtggtgcg atctcagctc actgcatcct ccatctcctg gagtcaagag 140281 attctcttgc ctcagcctcc caagtagctg ggaccacaag cgcacgccac caggcccagc 140341 taatttttgt atttttaata gagatggggt ttcaccatgt tggccaggct ggtctcgaac 140401 tcctgacctc atgtgatcca cccgcctcag tctcccaaag tgctgggatt acaggggtga 140461 gacaccacgc ctggccataa gttattggct tgataaatgc cattaatcta cagcaaaaac 140521 cttactaaaa gaagaaaatg tagacattca ccgcaaaatc aggaacaagg caaggatgcc 140581 cactgttaca atgccagcac aattctagat atccagatca cacaatttac aaaagaaatg 140641 tgagatataa acactggaag gaaaaagaca cactcttatt taaaaagatg atatcgtcat 140701 ctacaaaaaa ccaatgaaac caacagaaac taataaaact actcagagga gtaacaagtt 140761 ataagagcaa cctacaaaaa tcagatgtta tcctcattaa caataaccaa atagaaacca 140821 atatggacta taagatgtta caatagcaac taaaaccatt aagtagctaa taattagcct 140881 cccacaaaga cacatcagac ccacaaagga aaaattttag ttctatcaaa gaaactaaaa 140941 agaggtgtga tcaaatgggg gagatttagc atcaccatgg actggacaac ttaatgttat 141001 aaatatgctg atttttcatg gaacaattta aattcagtac aattcgaatc aaaattaaag 141061 tatgattttt tccagaaatt caacaaaata attctgaagt tttagctgag tatatttgaa 141121 aaggaataat aaagtgagag gggagaggga gctctctctc attctctctc tcttcctctc 141181 actggctctc tctctttctc tccaccagat agtaagaccc attggtaagc cacagtaaca 141241 aaagcagaaa aaatgcaaat acaccaatga aataaaatag ctcagaaact ggtccacttg 141301 gatatataca aacttggtgt agaattggct tcacatatgg cagaaaaaat atactttttt 141361 tattgtaagg taaattgcct cactgtaaag gggataaaat gctaaagcca aatctatatc 141421 tgactttcta ggtagagcac atataaatag atgaggaagg ggatcttcaa atcttatttt 141481 aggaaataat tatgatttgg gtgtgaagaa gggcatcttt gaaatatctc aaaactacaa 141541 accaacaagg tgaggcttgt ggatttgacc ttatcaatat caaggatttt tgatcaacag 141601 agactaccgt tgtcagattt ttgactgaga agaggtttta ctaaagttta aaatcagcaa 141661 tagtttgata cctagataga aggaacttct gtccttgaat caaaatcatg cagaaacaag 141721 gtgtgaaact caatttaaaa agtagtcaaa tgtcacaaaa taagaaaggg aagcccaaac 141781 ggctagcaaa tatgttgaaa tgatcaaact caccagctgt cagagaaatg aaaattaaaa 141841 ataaaacgaa ctatctattg cattacaacc atcattcgga caaaaagtat gaaagtcaaa 141901 aatacttcta actgaagttg tggggaaatt agaacacttg cagagtgtca ttccagacag 141961 cagcttggtg atcctgggtg catgtggggt ctgtctctgg tggccctggg tgcatgtgga 142021 ggtctgtttc tggtggcctc tgatgaatgc ggggtctgtc tctgatggtc ctaggtgaat 142081 gtgggtgttg tctctttctc tggtggtcct gggtggatgt ggggtgtgtc tctgatggtc 142141 ctgagtgaat gtgggtgtct gtcactttct ctagtggccc tgggtggaat atagtagccc 142201 tgtctctatt ggtcttgcat gaaatgtagt gagcttatgt ccactagtcc tgggtgcagt 142261 gtgtttagcc tctacatact catcaactgc tttattataa gtccaggagg gacgctgtcc 142321 agcaggtaag taaggaacac aggtgaaggt atcagtcgtg tggctgcatg tggtagagga 142381 aaagagagca caacctctgt ccatcactat ggtgacagag aagtaaaagg tggatgtatt 142441 ccacggaaca ctcctcaact gttaggaccc ctgagctaga catgtataca acaataccga 142501 taaacctcta aaacaaaatg ctgagcagaa aacccaagta gcaggatttc taatgctcac 142561 taaaacctct atgaacccag aaaccggaaa cacaaaccag cacaatctgt tctgcatgag 142621 cacatgtgtc ttggaggact ggaggacgca ttgccaagca cctaggcatg ggtgtctatg 142681 aggggaagag aaaggcagta ggcacaggag gtttgaagaa aactgatcat ttaaaatatg 142741 aaagatcata aaatcagagc tgtgccctgt aggaatcttg aaaatggtct gccatgaact 142801 taggaatcta attagctcaa aggtcagagt catgatcaag taagataaaa ggggtcagta 142861 cccacggctc attaccctgc tcttaccaaa cactgtgctc tctctgataa aagccacgtc 142921 tccagccccg tctctcagac acctgtgaaa agagaaacca tcaggggtaa gcacaggcag 142981 ccctccccag cccctccctg tggaacagta gccctggcac tcagcatcta tgggtttcta 143041 ctccctgcag ggcagggctc tgaagctt (2) INFORMATION FOR SEQ ID NO:2673: (i) SEQUENCE CHARACTERISTICS: WO 00/09525 PCT/US99/17712 EPI-109 883 (A) LENGTH: base cairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2673 1 gagctcagaa attcaagacc agcctgggca aggtagagag acccccatgt ctacaaaaaa 61 taaaaaatga ttagtcaggt gtggtggccc gcacctgtag ttccagctac tcaggacgct 121 gaggtgggag aatgaczcga gcccgtgagt tgaggctgca gtgagccgag atcacaccac 181 tccagcctag gcaagaaaa gaccctctct caaaaaaaaa aaaaaaaaaa aaaaaaaaag 241 aaccatcaaa atgttttgca cagcagtcac gccattttac atttctgcca gcaatgtgca 301 ccaggcttcc agtttctzca catcttcact aactcttatt tcctttgctt taaactctaa 361 ccatcaaagt aggtgtaaag ggtatctcac tgtggtttga tttgcatttc tctaatgact 421 aatagtgtta agtatcattt catgtgcatg ttggccattt atatgtcatt ggagaaatgt 481 ctactcaaac cgtttgczca tttagaaact taggtaggtt ggtctgagtg cagtggtgtt 541 taaaactaat tttttttzga gacaaagtct cactctgtcg cccaggctgg aatgcaatgg 601 tgagatcttg gctcactaca acctccatct cctgggttca agcaattctt ctgcctcagc 661 ctctcaagta gctgggatta caggcatgcg ccaccacgcc tggctaattt ttgtattttt 721 ggtagagacg ggggtttctc catgttggcc aggctggtct cgaactcttg acctcaggtg 781 atccacctgc ctcggcctcc acagggctag gattagaggt gtgagccacc gcaccaggcc 841 gtttaaaact aatggagcac aaccagttac caatatcttt gttccttctc cactccctct 901 gcttcaactt gactagccta aaataaataa atttaaaaaa ctgggcacag tggctcacac 961 ctgtaatccc agcacttgg gaggccgagg caggaggatt acttgagcat aggagttcaa 1021 gatcagcctg ggcaactagt gaaaaaccat ctcaaaaaag aaaaattagc caggcatggt 1081 ggcatgcacc tgtggtttca gctacttaga gcagaggtgg aggatcgctt gattctggag 1141 ttcaaggttg cattgagctg tgatcgcgcc agtgcactct cgcttgggtg acagagtaag 1201 accttgtctc aaaaaattta aaacaaaaca aaaaaaactg gttatttgtc tttttattgg 1261 tgaattataa gagttttaaa aaatatattc tggaaacaaa tcccttatta gagatatgat 1321 ttgcaaatat tttctccaat tttttttttt tttaaagaca aagtttcact ttgtcgccca 1381 ggctggtctt gattcctggc ttcaagagat gctcttacct ccacctcctg aagcccaaag 1441 ggctggaatt acagccagtg agcctgcacc cagcctccaa ttctttagat tttacatttt 1501 agaaccaaaa tgggttaaat acactgttct gtaatctgct cttttcttta atagtagttc 1561 atgtacatct ttcaaggtcc agagaaagct ctcactttct ccccgtttta tttttccttc 1621 cctcattctt tttcactgct gcatagcatt ccattgtaat tttgccactg tttattagac 1681 cagtcctctg ctgagcttta cagagccctt agttggatgt tagtgagaac catgacagca 1741 gtgagactgt catctccctg acatgctgtc agcttttgga tgatgtgaaa atgcaagcag 1801 gcacaggaaa tgtctctaac ttgcttacac ttcctccctg aaccctgcgg tttcacaact 1861 cctgcaggca cacctccctc cccgcctgcc agtgtcacca gcctgttgcc tctgtgagaa 1921 agtaccactg taagaggcca aagggcatga tcattttcct ctttcaccct gtctaggttg 1981 ccagcaaatc ccacgggcct cctgacgctg cccctggggc cacaggtccc tcgagtgctg 2041 gaaggatgaa ggattcctgc atcactgtga tggccatggc gctgctgtct gggttctttt 2101 tcttcggtag gcaagggagg aggcagggga agggacatgt gtctgtgacc agagaaactg 2161 cagggcttgg tgcagctgga gtaaacaagg agctgccccc taaaagtggg attggcctta 2221 gggatatggg gccccaggga tcttggaagg agaaagggga gagcggggaa ataaaag (2) INFORMATION FOR SEQ ID NO:2674: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2674 1 gatcttggct cactacaacc tccatctggt gggttcaagc aattcttctg cctcagcctc 61 tcaagtagct gggattacag gcatgcgcca ccacgcccgg ctaatttttg tatttttggt 121 agagacgggg gtttctccat gttggccagg ctggtctcga actcttgacc tcaggtgatc 181 cacctgcctc ggcctcccac aggctaggat tagaggtgtg agccaccgca ccaggccgtt 241 taaaactaat ggagcacaac cagttaccaa tatctttgtt ccttctccac tccctctgct 301 tcacttgact agcctaaaat aaataaattt aaaaaactgg gcacagtggc tcacacctgt 361 aatcccagca ctttgggagg ccgaggcagg aggattactt gagcatagga gttcaagatc 421 agcctgggca acatagtgaa aaaccatctc aaaaaagaaa aaattagcca ggcatggtgg 481 catgcacctg tggtttcagc tacttaggag cagaggtggg aggatcgctt gattctggga 541 gttcaaggtt gcattgagct gtgatcgcgc cagtgcactc tcgcttgggt gacagagcaa 601 gaccttgtct caaaaaattt aaaacaaaac aaaaaaaact ggttatttgt ctttttattg 661 ttgaattata agagttttaa aaaatatatt ctggaaacaa atcccttatt agagatatga 721 tttgcaaata ttttctccaa tttttttttt tttaaagaca aagtttcact ttggtgccca 781 ggctggtctt cattcctggc ttcaagagat gctcttacct ccacctcctg aagccccaaa 841 gggctggaat tacagccagt gagccactgc acccagcctc caattcttta gattttacat 901 tttagaacca aaatgggtta aatacactgt tctgtaatct gctcttttct ttaatagtag 961 ttcatgtaca tctttcaagg tccagagaaa gctctcactt tctccccgtt ttatttttcc 1021 ttccctcatt ctttttcact gctgcatagc attccattgt aattttgcca ctgtttatta WO 00/09525 PCT/US99/17712 EPI-109 884 1081 gaccagtcct ctgctgagct ttacagagcc cttagttggg atgttagtga gaaaccatga 1141 cagcagtgga gactgtcatc tccctgacat gctgtcagct tttggatgat gtgaaaatgc 1201 aagcaggcac aggaaatgtc tctctaactt gcttacactt cctccctgaa ccctgcggtt 1261 tcacaactcc tgcaggcaca cctccctccc cgcctgccag tgtcaccagc ctgttgcctc 1321 tgtgagaaag taccactgta agaggccaaa gggcatgatc attttcctct ttcaccctgt 1381 ctaggttgcc agcaaatccc acgggcctcc tgacgctgcc cctggggcca caggtccctc 1441 gagtgctgga aggatgaagg attcctgcat cactgtgatg gccatggcgc tgctgtctgg 1501 gttctttttc ctcggtaggc (2) INFORMATION FOR SEQ ID NO:2675: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: -base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2675 1 cagggcagac tggtagcaaa gcccccacgc ccagccagga gcaccgccgc ggactccagc 61 acaccgaggg acatgctggg cctgcgcccc ccactgctcg ccctggtggg gctgctctcc 121 ctcgggtgcg tcctctctca ggagtgcacg aagttcaag tcagcagctg ccgggaatgc 181 atcgagtcgg ggcccggctg cacctggtgc cagaagctga acttcacagg gccgggggat 241 cctgactcca ttcgctgcga cacccggcca cagctgctca tgaggggctg tgcggctgac 301 gacatcatgg accccacaag cctcgctgaa acccaggaag accacaatgg gggccagaag 361 cagctgtccc cacaaaaagt gacgctttac ctgcgaccag gccaggcagc agcgttcaac 421 gtgaccttcc ggcgggccaa gggctacccc atcgacctgt actatctgat ggacctctcc 481 tactccatgc ttgatgacct caggaatgtc aagaagctag gtggcgacct gctccgggcc 541 ctcaacgaga tcaccgagtc cggccgcatt ggcttcgggt ccttcatgga caagaccgtg 601 ctgccgttcg tgaacacgca ccctgataag ctgcgaaacc catgccccaa caaggagaaa 661 gagtgccagc ccccgtttgc cttcaggcac gtgctgaagc tgaccaacaa ctccaaccag 721 tttcagaccg aggtcgggaa gcagctgatt tccggaaacc tggatgcacc cgagggtggg 781 ctggacgcca tgatgcaggt cgccgcctgc ccggaggaaa tcggctggcg caacgtcacg 841 cggctgctgg tgtttgccac tgatgacggc ttccatttcg cgggcgacgg aaagctgggc 901 gccatcctga cccccaacga cggccgctgt cacctggagg acaacttgta caagaggagc 961 aacgaattcg actacccatc ggtgggccag ctggcgcaca agctggctga aaacaacatc 1021 cagcccatct tcgcggtgac cagtaggatg gtgaagacct acgagaaact caccgagatc 1081 atccccaagt cagccgtggg ggagctgtct gaggactcca gcaatgtggt ccatctcatt 1141 aagaatgctt acaataaact ctcctccagg gtcttcctgg atcacaacgc cctccccgac 1201 accctgaaag tcacctacga ctccttctgc agcaatggag tgacgcacag gaaccagccc 1261 agaggtgact gtgatggcgt gcagatcaat gtcccgatca ccttccaggt gaaggtcacg 1321 gccacagagt gcatccagga gcagtcgttt gtcatccggg cgctgggctt cacggacata 1381 gtgaccgtgc aggttcttcc ccagtgtgag tgccggtgcc gggaccagag cagagaccgc 1441 agcctctgcc atggcaaggg cttcttggag tgcggcatct gcaggtgtga cactggctac 1501 attgggaaaa actgtgagtg ccagacacag ggccggagca gccaggagct ggaaggaagc 1561 tgccggaagg acaacaactc catcatctgc tcagggctgg gggactgtgt ctgcgggcag 1621 tgcctgtgcc acaccagcga cgtccccggc aagctgatat acgggcagta ctgcgagtgt 1681 gacaccatca actgtgagcg ctacaacggc caggtctgcg gcggcccggg gagggggctc 1741 tgcttctgcg ggaagtgccg ctgccacccg ggctttgagg gctcagcgtg ccagtgcgag 1801 aggaccactg agggctgcct gaacccgcgg cgtgttgagt gtagtggtcg tggccggtgc 1861 cgctgcaacg tatgcgagtg ccattcaggc taccagctgc ctctgtgcca ggagtgcccc 1921 ggctgcccct caccctgtgg caagtacatc tcctgcgccg agtgcctgaa gttcgaaaag 1981 ggcccctttg ggaagaactg cagcgcggcg tgtccgggcc tgcagctgtc gaacaacccc 2041 gtgaagggca ggacctgcaa ggagagggac tcagagggct gctgggtggc ctacacgctg 2101 gagcagcagg acgggatgga ccgctacctc atctatgtgg atgagagccg agagtgtgtg 2161 gcaggcccca acatcgccgc catcgtcggg ggcaccgtgg caggcatcgt gctgatcggc 2221 attctcctgc tggtcatctg gaaggctctg atccacctga gcgacctccg ggagtacagg 2281 cgctttgaga aggagaagct caagtcccag tggaacaatg ataatcccct tttcaagagc 2341 gccaccacga cggtcatgaa ccccaagttt gctgagagtt aggagcactt ggtgaagaca 2401 aggccgtcag gacccaccat gtctgcccca tcacgcggcc gagacatggc ttggccacag 2461 ctcttgagga tgtcaccaat taaccagaaa tccagttatt ttccgccctc aaaatgacag 2521 ccatggccgg ccggtgcttc tgggggctcg tcggggggac agctccactc tgactgqcac 2581 agtctttgca tggagacttg aggagggctt gaggttggtg aggttaggtg cgtgtttcct 2641 gtgcaagtca ggacatcagt ctgattaaag gtggtgccaa tttatttaca tttaaacttg 2701 tcagggtata aaatgacatc ccattaatta tattgttaat caatcacgtg tatagaaaaa 2761 aaaataaaac ttcaat (2) INFORMATION FOR SEQ ID NO:2676: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single WO 00/09525 PCT/US99/17712 EPI-109 885 (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2676 1 ctcgccctgg tggggctgct ctccctcggg tgcgtcctct ctcaggagtg cacgaagttc 61 aaggtcagca gctgccggga atgcatcgag tcggggcccg gctgcacctg gtgccagaag 121 ctgaacttca cagggccggg ggatcctgac tccattcgct gcgacacccg gccacagctg 181 ctcatgaggg gctgtgcggc tgacgacatc atggacccca caagcctcgc tgaaacccag 241 gaagaccaca atgggggcca gaagcagctg tccccacaaa aagtgacgct ttacctgcga 301 ccaggccagg cagcagcgtt caacgtgacc ttccggcggg ccaagggcta ccccatcgac 361 ctgtactatc tgatggacct ctcctactcc atgcttgatg acctcaggaa tgtcaagaag 421 ctaggtggcg acctgctccg ggccctcaac gagatcaccg agtccggccg cattggcttc 481 gggtccttcg tggacaagac cgtgctgccg ttcgtgaaca cgcaccctga taagctgcga 541 aacccatgcc ccaacaagga gaaagagtgc ccgcccccgt ttgccttcag gcacgtgctg 601 aagctgacca acaactccaa ccagtttcag accgaggtcg ggaagcagct gatttccgga 661 aacctggatg cacccgaggg tgggctggac gccatgatgc aggtcgccgc ctgcccggag 721 gaaatcggct ggcgcaacgt cacgcggctg ctggtgtttg ccactgatga cggcttccat 781 ttcgcgggcg acggaaagct gggcgccatc ctgaccccca acgacggccg ctgtcacctg 841 gaggacaact tgtacaagag gagcaacgaa ttcgactacc catcggtggg ccagctggcg 901 cacaagctgg ctgaaaacaa catccagccc atcttcgcgg tgaccagtag gatggtgaag 961 acctacgaga aactcaccga gatcatcccc aagtcagccg tgggggagct gtctgaggac 1021 tccagcaatg tggtccatct cattaagaat gcttacaata aactctcctc cagggtcttc 1081 ctggatcaca acgccctccc cgacaccctg aaagtcacct acgactcctt ctgcagcaat 1141 ggagtgacgc acaggaacca gcccagaggt gactgtgatg gcgtgcagat caatgtcccg 1201 atcaccttcc aggtgaaggt cacggccaca gagtgcatcc aggagcagtc gtttgtcatc 1261 cgggcgctgg gcttcacgga catagtgacc gtgcaggtcc ttccccagtg tgagtgccgg 1321 tgccgggacc agagcagaga ccgcagcctc tgccatggca agggcttctt ggagtgcggc 1381 atctgcaggt gtgacactgg ctacattggg aaaaactgtg agtgccagac acagggccgg 1441 agcagccagg agctggaagg aagctgccgg aaggacaaca actccatcat ctgctcaggg 1501 ctgggggact gtgtctgcgg gcagtgcctg tgccacacca gcgacgtccc cggcaagctg 1561 atatacgggc agtactgcga gtgtgacacc atcaactgtg agcgctacaa cggccaggtc 1621 tgcggcggcc cggggagggg gctctgcttc tgcgggaagt gccgctgcca cccgggcttt 1681 gagggctcag cgtgccagtg cgagaggacc actgagggct gcctgaaccc gcggcgtgtt 1741 gagtgtagtg gtcgtggccg gtgccgctgc aacgtatgcg agtgccattc aggctaccag 1801 ctgcctctgt gccaggagtg ccccggctgc ccctcaccct gtggcaagta catctcctgc 1861 gccgagtgcc tgaagttcga aaagggcccc tttgggaaga actgcagcgc ggcgtgtccg 1921 ggcctgcagc tgtcgaacaa ccccgtgaag ggcaggacct gcaaggagag ggactcagag 1981 ggctgctggg tggcctacac gctggagcag caggacggga tggaccgcta cctcatctat 2041 gtggatgaga gccgagagtg tgtggcaggc cccaacatcg ccgccatcgt cgggggcacc 2101 gtggcaggca tcgtgctgat cggcattctc ctgctggtca tctggaaggc tctgatccac 2161 ctgagcgacc tccgggagta caggcgcttt gagaaggaga agctcaagtc ccagtggaac 2221 aatgataatc cccttttcaa gagcgccacc acgacggtca tgaaccccaa gtttgctgag 2281 agttaggagc a (2) INFORMATION FOR SEQ ID NO:2677: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2677 1 gagctcagaa attcaagacc agcctgggca aggtagagag acccccatgt ctacaaaaaa 61 taaaaaatga ttagtcaggt gtggtggccc gcacctgtag ttccagctac tcaggacgct 121 gaggtgggag aatgactcga gcccgtgagt tgaggctgca gtgagccgag atcacaccac 181 tccagcctag gcaagagtga gaccctctct caaaaaaaaa aaaaaaaaaa aaaaaaaaag 241 aaccatcaaa atgttttgca cagcagtcac gccattttac atttctgcca gcaatgtgca 301 ccaggcttcc agtttcttca catcttcact aactcttatt tcctttgctt taaactctaa 361 ccatcaaagt aggtgtaaag ggtatctcac tgtggtttga tttgcatttc tctaatgact 421 aatagtgtta agtatcattt catgtgcatg ttggccattt atatgtcatt ggagaaatgt 481 ctactcaaac cgtttgctca tttagaaact taggtaggtt ggtctgagtg cagtggtgtt 541 taaaactaat ttttttttga gacaaagtct cactctgtcg cccaggctgg aatgcaatgg 601 tgagatcttg gctcactaca acctccatct cctgggttca agcaattctt ctgcctcagc 661 ctctcaagta gctgggatta caggcatgcg ccaccacgcc tggctaattt ttgtattttt 721 ggtagagacg ggggtttctc catgttggcc aggctggtct cgaactcttg acctcaggtg 781 atccacctgc ctcggcctcc acagggctag gattagaggt gtgagccacc gcaccaggcc 841 gtttaaaact aatggagcac aaccagttac caatatcttt gttccttctc cactccctct 901 gcttcaactt gactagccta aaataaataa atttaaaaaa ctgggcacag tggctcacac 961 ctgtaatccc agcactttgg gaggccgagg caggaggatt acttgagcat aggagttcaa 1021 gatcagcctg ggcaactagt gaaaaaccat ctcaaaaaag aaaaattagc caggcatggt 1081 ggcatgcacc tgtggtttca gctacttaga gcagaggtgg aggatcgctt gattctggag 1141 ttcaaggttg cattgagctg tgatcgcgcc agtgcactct cgcttgggtg acagagtaag WO 00/09525 PCT/US99/17712 EPI-109 886 1201 accttgtctc aaaaaattta aaacaaaaca aaaaaaactg gttatttgtc tttttattgg 1261 tgaattataa gagttttaaa aaatatattc tggaaacaaa tcccttatta gagatatgat 1321 ttgcaaatat tttctccaat tttttttttt tttaaagaca aagtttcact ttgtcgccca 1381 ggctggtctt gattcctggc ttcaagagat gctcttacct ccacctcctg aagcccaaag 1441 ggctggaatt acagccagtg agcctgcacc cagcctccaa ttctttagat tttacatttt 1501 agaaccaaaa tgggttaaat acactgttct gtaatctgct cttttcttta atagtagttc 1561 atgtacatct ttcaaggtcc agagaaagct ctcactttct ccccgtttta tttttccttc 1621 cctcattctt tttcactgct gcatagcatt ccattgtaat tttgccactg tttattagac 1681 cagtcctctg ctgagcttta cagagccctt agttggatgt tagtgagaac catgacagca 1741 gtgagactgt catctccctg acatgctgtc agcttttgga tgatgtgaaa atgcaagcag 1801 gcacaggaaa tgtctctaac ttgcttacac ttcctccctg aaccctgcgg tttcacaact 1861 cctgcaggca cacctccctc cccgcctgcc agtgtcacca gcctgttgcc tctgtgagaa 1921 agtaccactg taagaggcca aagggcatga tcattttcct ctttcaccct gtctaggttg 1981 ccagcaaatc ccacgggcct cctgacgctg cccctggggc cacaggtccc tcgagtgctg 2041 gaaggatgaa ggattcctgc atcactgtga tggccatggc gctgctgtct gggttctttt 2101 tcttcggtag gcaagggagg aggcagggga agggacatgt gtctgtgacc agagaaactg 2161 cagggcttgg tgcagctgga gtaaacaagg agctgccccc taaaagtggg attggcctta 2221 gggatatggg gccccaggga tcttggaagg agaaagggga gagcggggaa ataaaag 1 gatcttggct cactacaacc tccatctggt gggttcaagc aattcttctg cctcagcctc 61 tcaagtagct gggattacag gcatgcgcca ccacgcccgg ctaatttttg tatttttggt 121 agagacgggg gtttctccat gttggccagg ctggtctcga actcttgacc tcaggtgatc 181 cacctgcctc ggcctcccac aggctaggat tagaggtgtg agccaccgca ccaggccgtt 241 taaaactaat ggagcacaac cagttaccaa tatctttgtt ccttctccac tccctctgct 301 tcacttgact agcctaaaat aaataaattt aaaaaactgg gcacagtggc tcacacctgt 361 aatcccagca ctttgggagg ccgaggcagg aggattactt gagcatagga gttcaagatc 421 agcctgggca acatagtgaa aaaccatctc aaaaaagaaa aaattagcca ggcatggtgg 481 catgcacctg tggtttcagc tacttaggag cagaggtggg aggatcgctt gattctggga 541 gttcaaggtt gcattgagct gtgatcgcgc cagtgcactc tcgcttgggt gacagagcaa 601 gaccttgtct caaaaaattt aaaacaaaac aaaaaaaact ggttatttgt ctttttattg 661 ttgaattata agagttttaa aaaatatatt ctggaaacaa atcccttatt agagatatga 721 tttgcaaata ttttctccaa tttttttttt tttaaagaca aagtttcact ttggtgccca 781 ggctggtctt cattcctggc ttcaagagat gctcttacct ccacctcctg aagccccaaa 841 gggctggaat tacagccagt gagccactgc acccagcctc caattcttta gattttacat 901 tttagaacca aaatgggtta aatacactgt tctgtaatct gctcttttct ttaatagtag 961 ttcatgtaca tctttcaagg tccagagaaa gctctcactt tctccccgtt ttatttttcc 1021 ttccctcatt ctttttcact gctgcatagc attccattgt aattttgcca ctgtttatta 1081 gaccagtcct ctgctgagct ttacagagcc cttagttggg atgttagtga gaaaccatga 1141 cagcagtgga gactgtcatc tccctgacat gctgtcagct tttggatgat gtgaaaatgc 1201 aagcaggcac aggaaatgtc tctctaactt gcttacactt cctccctgaa ccctgcggtt 1261 tcacaactcc tgcaggcaca cctccctccc cgcctgccag tgtcaccagc ctgttgcctc 1321 tgtgagaaag taccactgta agaggccaaa gggcatgatc attttcctct ttcaccctgt 1381 ctaggttgcc agcaaatccc acgggcctcc tgacgctgcc cctggggcca caggtccctc 1441 gagtgctgga aggatgaagg attcctgcat cactgtgatg gccatggcgc tgctgtctgg 1501 gttctttttc ttcggtaggc 1 cagggcagac tggtagcaaa gcccccacgc ccagccagga gcaccgccgc ggactccagc 61 acaccgaggg acatgctggg cctgcgcccc ccactgctcg ccctggtggg gctgctctcc 121 ctcgggtgcg tcctctctca ggagtgcacg aagttcaagg tcagcagctg ccgggaatgc 181 atcgagtcgg ggcccggctg cacctggtgc cagaagctga acttcacagg gccgggggat 241 cctgactcca ttcgctgcga cacccggcca cagctgctca tgaggggctg tgcggctgac 301 gacatcatgg accccacaag cctcgctgaa acccaggaag accacaatgg gggccagaag 361 cagctgtccc cacaaaaagt gacgctttac ctgcgaccag gccaggcagc agcgttcaac 421 gtgaccttcc ggcgggccaa gggctacccc atcgacctgt actatctgat ggacctctcc 481 tactccatgc ttgatgacct caggaatgtc aagaagctag gtggcgacct gctccgggcc 541 ctcaacgaga tcaccgagtc cggccgcatt ggcttcgggt ccttcgtgga caagaccgtg 601 ctgccgttcg tgaacacgca ccctgataag ctgcgaaacc catgccccaa caaggagaaa 661 gagtgccagc ccccgtttgc cttcaggcac gtgctgaagc tgaccaacaa ctccaaccag 721 tttcagaccg aggtcgggaa gcagctgatt tccggaaacc tggatgcacc cgagggtggg 781 ctggacgcca tgatgcaggt cgccgcctgc ccggaggaaa tcggctggcg caacgtcacg 841 cggctgctgg tgtttgccac tgatgacggc ttccatttcg cgggcgacgg aaagctgggc 901 gccatcctga cccccaacga cggccgctgt cacctggagg acaacttgta caagaggagc 961 aacgaattcg actacccatc ggtgggccag ctggcgcaca agctggctga aaacaacatc 1021 cagcccatct tcgcggtgac cagtaggatg gtgaagacct acgagaaact caccgagatc 1081 atccccaagt cagccgtggg ggagctgtct gaggactcca gcaatgtggt ccatctcatt 1141 aagaatgctt acaataaact ctcctccagg gtcttcctgg atcacaacgc cctccccgac 1201 accctgaaag tcacctacga ctccttctgc agcaatggag tgacgcacag gaaccagccc 1261 agaggtgact gtgatggcgt gcagatcaat gtcccgatca ccttccaggt gaaggtcacg 1321 gccacagagt gcatccagga gcagtcgttt gtcatccggg cgctgggctt cacggacata 1381 gtgaccgtgc aggttcttcc ccagtgtgag tgccggtgcc gggaccagag cagagaccgc WO 00/09525 PCT/US99/17712 EPI-109 887 1441 agcctctgcc atggcaaggg cttcttggag tgcggcatct gcaggtgtga cactggctac 1501 attgggaaaa actgtgagtg ccagacacag ggccggagca gccaggagct ggaaggaagc 1561 tgccggaagg acaacaactc carcatctgc tcagggctgg gggactgtgt ctgcgggcag 1621 tgcctgtgcc acaccagcga cgtccccggc aagctgatat acgggcagta ctgcgagtgt 1681 gacaccatca actgtgagcg ctacaacggc caggtctgcg gcggcccggg gagggggctc 1741 tgcttctgcg ggaagtgccg ctgccacccg ggctttgagg gctcagcgtg ccagtgcgag 1801 aggaccactg agggctgcct gaacccgcgg cgtgttgagt gtagtggtcg tggccggtgc 1861 cgctgcaacg tatgcgagtg ccattcaggc taccagctgc ctctgtgcca ggagtgcccc 1921 ggctgcccct caccctgtgg caagtacatc tcctgcgccg agtgcctgaa gttcgaaaag 1981 ggcccctttg ggaagaactg cagcgcggcg tgtccgggcc tgcagctgtc gaacaacccc 2041 gtgaagggca ggacctgcaa ggagagggac tcagagggct gctgggtggc ctacacgctg 2101 gagcagcagg acgggatgga ccgctacctc atctatgtgg atgagagccg agagtgtgtg 2161 gcaggcccca acatcgccgc catcgtcggg ggcaccgtgg caggcatcgt gctgatcggc 2221 attctcctgc tggtcatctg gaaggctctg atccacctga gcgacctccg ggagtacagg 2281 cgctttgaga aggagaagct caagtcccag tggaacaatg ataatcccct tttcaagagc 2341 gccaccacga cggtcatga'a ccccaagttt gctgagagtt aggagcactt ggtgaagaca 2401 aggccgtcag gacccaccat gtctgcccca tcacgcggcc gagacatggc ttggccacag 2461 ctcttgagga tgtcaccaat taaccagaaa tccagttatt ttccgccctc aaaatgacag 2521 ccatggccgg ccggtgcttc tgggggctcg tcggggggac agctccactc tgactggcac 2581 agtctttgca tggagacttg aggagggctt gaggttggtg aggttaggtg cgtgtttcct 2641 gtgcaagtca ggacatcagt ctgattaaag gtggtgccaa tttatttaca tttaaacttg 2701 tcagggtata aaatgacatc ccattaatta tattgttaat caatcacgtg tatagaaaaa 2761 aaaataaaac ttcaat 1 ctcgccctgg tggggctact ctccctcggg tgcgtcctct ctcaggagtg cacgaagttc 61 aaggtcagca gctgccggga atgcatcgag tcggggcccg gctgcacctg gtgccagaag 121 ctgaacttca cagggccggg ggatcctgac tccattcgct gcgacacccg gccacagctg 181 ctcatgaggg gctgtgcggc tgacgacatc atggacccca caagcctcgc tgaaacccag 241 gaagaccaca atgggggcca gaagcagctg tccccacaaa aagtgacgct ttacctgcga 301 ccaggccagg cagcagcgtt caacgtgacc ttccggcggg ccaagggcta ccccatcgac 361 ctgtactatc tgatggacct ctcctactcc atgcttgatg acctcaggaa tgtcaagaag 421 ctaggtggcg acctgctccg ggccctcaac gagatcaccg agtccggccg cattggcttc 481 gggtccttcg tggacaagac cgtgctgccg ttcgtgaaca cgcaccctga taagctgcga 541 aacccatgcc ccaacaagga gaaagagtgc ccgcccccgt ttgccttcag gcacgtgctg 601 aagctgacca acaactccaa ccagtttcag accgaggtcg ggaagcagct gatttccgga 661 aacctggatg cacccgaggg tgggctggac gccatgatgc aggtcgccgc ctgcccggag 721 gaaatcggct ggcgcaacgt cacgcggctg ctggtgtttg ccactgatga cggcttccat 781 ttcgcgggcg acggaaagct gggcgccatc ctgaccccca acgacggccg ctgtcacctg 841 gaggacaact tgtacaagag gagcaacgaa ttcgactacc catcggtggg ccagctggcg 901 cacaagctgg ctgaaaacaa catccagccc atcttcgcgg tgaccagtag gatggtgaag 961 acctacgaga aactcaccga gatcatcccc aagtcagccg tgggggagct gtctgaggac 1021 tccagcaatg tggtccatc.t cattaagaat gcttacaata aactctcctc cagggtcttc 1081 ctggatcaca acgccctccc cgacaccctg aaagtcacct acgactcctt ctgcagcaat 1141 ggagtgacgc acaggaacca gcccagaggt gactgtgatg gcgtgcagat caatgtcccg 1201 atcaccttcc aggtgaaggt cacggccaca gagtgcatcc aggagcagtc gtttgtcatc 1261 cgggcgctgg gcttcacgga catagtgacc gtgcaggtcc ttccccagtg tgagtgccgg 1321 tgccgggacc agagcagaga ccgcagcctc tgccatggca agggcttctt ggagtgcggc 1381 atctgcaggt gtgacactgg ctacattggg aaaaactgtg agtgccagac acagggccgg 1441 agcagccagg agctggaagg aagctgccgg aaggacaaca actccatcat ctgctcaggg 1501 ctgggggact gtgtctgcgg gcagtgcctg tgccacacca gcgacgtccc cggcaagctg 1561 atatacgggc agtactgcga gtgtgacacc atcaactgtg agcgctacaa cggccaggtc 1621 tgcggcggcc cggggagggg gctctgcttc tgcgggaagt gccgctgcca cccgggcttt 1681 gagggctcag cgtgccagtg cgagaggacc actgagggct gcctgaaccc gcggcgtgtt 1741 gagtgtagtg gtcgtggccg gtgccgctgc aacgtatgcg agtgccattc aggctaccag 1801 ctgcctctgt gccaggagtg ccccggctgc ccctcaccct gtggcaagta catctcctgc 1861 gccgagtgcc tgaagttcga aaagggcccc tttgggaaga actgcagcgc ggcgtgtccg 1921 ggcctgcagc tgtcgaacaa ccccgtgaag ggcaggacct gcaaggagag ggactcagag 1981 ggctgctggg tggcctacac gctggagcag caggacggga tggaccgcta cctcatctat 2041 gtggatgaga gccgagagtg tgtggcaggc cccaacatcg ccgccatcgt cgggggcacc 2101 gtggcaggca tcgtgctgat cggcattctc ctgctggtca tctggaaggc tctgatccac 2161 ctgagcgacc tccgggagta caggcgcttt gagaaggaga agctcaagtc ccagtggaac 2221 aatgataatc cccttttcaa gagcgccacc acgacggtca tgaaccccaa gtttgctgag 2281 agttaggagc a (2) INFORMATION FOR SEQ ID NO:2678: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear WO 00/09525 PCT/US99/17712 EPI-109 888 (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2678 1 ggaattccgg gcccggtctt tcctcccgcc gccgccggcc tggtcccggg gactggcctc 61 cacgtccgac tcgtccgagc tgaagcccag cagcactttg ctgccagccg cgggggcggc 121 ggaggcgccc ccgggccctc ccaggaggct ctctgggcca gaggccgaga ttcggcacag 181 gcccccagga gtccgtaagt aggagaggtc gcccgagacc ggccggaccc ccatccccgc 241 ggccgccgcc gccgctggtc ccgcggctgc gaccgtggcg gctgccgctg gaaaatgtct 301 caggagaggc ccacgttcta ccggcaggag ctgaacaaga caatctggga ggtgcccgag 361 cgttaccaga acctgtctcc agtgggctct ggcgcctatg gctctgtgtg tgctgctttt 421 gacacaaaaa cggggttacg tgtggcagtg aagaagctct ccagaccatt tcagtccatc 481 attcatgcga aaagaaccta cagagaactg cggttactta aacatatgaa acatgaaaat 541 gtgattggtc tgttggacgt ttttacacct gcaaggtctc tggaggaatt caatgatgtg 601 tatctggtga cccatctcat gggggcagat ctgaacaaca ttgtgaaatg tcagaagctt 661 acagatgacc atgttcagtt ccttatctac caaattctcc gaggtctaaa gtatatacat 721 tcagctgaca taattcacag ggacctaaaa cctagtaatc tagctgtgaa tgaagactgt 781 gagctgaaga ttctggattt tggactggct cggcacacag atgatgaaat gacaggctac 841 gtggccacta ggtggtacag ggctcctgag atcatgctga actggatgca ttacaaccag 901 acagttgata tttggtcagt gggatgcata atggccgagc tgttgactgg aagaacattg 961 tttcctggta cagaccatat tgatcagttg aagctcattt taagactcgt tggaacccca 1021 ggggctgagc ttttgaagaa aatctcctca gagtctgcaa gaaactatat tcagtctttg 1081 actcagatgc cgaagatgaa ctttgcgaat gtatttattg gtgccaatcc cctggctgtc 1141 gacttgctgg agaagatgct tgtattggac tcagataaga gaattacagc ggcccaagcc 1201 cttgcacatg cctactttgc tcagtaccac gatcctgatg atgaaccagt ggccgatcct 1261 tatgatcagt cctttgaaag cagggacctc cttatagatg agtggaaaag cctgacctat 1321 gatgaagtca tcagctttgt gccaccaccc cttgaccaag aagagatgga gtcctgagca 1381 cctggtttct gttctgttga tcccacttca ctgtgagggg aaggcctttt cacgggaact 1441 ctccaaatat tattcaagtg cctcttgttg cagagatttc ctccatggtg gaagggggtg 1501 tgcgtgcgtg tgcgtgcgtg ttagtgtgtg tgcatgtgt (2) INFORMATION FOR SEQ ID NO:2679: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2679 1 tggttaacgc cagggttttc ccagtcacga acgttgtaaa acgacggcca gtgccaagct 61 aaaattaacc ttcactaaag ggaataagct tgcggccgct tcgggtttcc ggaggggccg 121 gagggcgggc gagggcgtca cgtgcgcgcc gcccgcgggc cggttggtcc ccgggcgggg 181 gaggggccgt gcgcagcctg ggtcggggtc gggccggggt cggcacctgg gacatccctg 241 agggaagggc cgggagcggg agcgccccag cggccggcgg gcgggcgggc gagcggacga 301 gcggcgcgga gccggcccga ggcgcgcgcc gagggagccc cgtccccggt cgtgggggca 361 ccgcccgcag gctctgcggg gtgggcagct cccgggcctg ccatgagctc tccgccgccc 421 gcccgcagtg gcttttaccg ccaggaggtg accaagacgg cctgggaggt gcgcgccgtg 481 taccgggacc tgcagcccgt gggctcgggc gcctacggcg cggtgtgctc ggccgtggac 541 ggccgcaccg gcgctaaggt ggccatcaag aagctgtatc ggcccttcca gtccgagctg 601 ttcgccaagc gcgcctaccg cgagctgcgc ctgctcaagc acatgcgcca cgagaacgtg 661 atcgggctgc tggacgtatt cactcctgat gagaccctgg atgacttcac ggacttttac 721 ctggtgatgc cgttcatggg caccgacctg ggcaagctca tgaaacatga gaagctaggc 781 gaggaccgga tccagttcct cgtgtaccag atgctgaagg ggctgaggta tatccacgct 841 gccggcatca tccacagaga cctgaagccc ggcaacctgg ctgtgaacga agactgtgag 901 ctgaagatcc tggacttcgg cctggccagg caggcagaca gtgagatgac tgggtacgtg 961 gtgacccggt ggtaccgggc tcccgaggtc atcttgaatt ggatgcgcta cacgcagacg 1021 gtggacatct ggtccgtggg ctgcatcatg gcggagatga tcacaggcaa gacgctgttc 1081 aagggcagcg accacctgga ccagctgaag gagatcatga aggtgacggg gacgcctccg 1141 gctgagtttg tgcagcggct gcagagcgat gaggccaaga acaacatgaa gggcctcccc 1201 gaattggaga agaaggattt tgcctctatc ctgaccaatg caagccctct ggctgtgaac 1261 ctcctggaga agatgctggt gctggacgcg gagcagcggg tgacggcagg cgaggcgctg 1321 gcccatccct acttcgagtc cctgcacgac acggaagatg agccccaggt ccagaagtat 1381 gatgactcct ttgacgacgt tgaccgcaca ctggatgaat ggaagcgtgt tacttacaaa 1441 gaggtgctca gcttcaagcc tccccggcag ctgggggcca gggtctccaa ggagacgcct 1501 ctgtgaagat ctctgggctc cggggtggca gtgaggacca ccttcacctt (2) INFORMATION FOR SEQ ID NO:2680: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2680 WO 00/09525 PCT/US99/17112 EPI-109 889 1 ggaattcccg gcccggtctt tcctcccgcc gccgccggcc tggtcccggg gactggcctc 61 cacgtccgac zcgtccgagc tgaagcccag cagcactttg ctgccagccg cgggggcggc 121 ggaggcgccc ccgggccctc ccaggaggct ctctgggcca gaggccgaga ttcggcacag 181 gcccccagga gtccgtaagt aggagaggtc gcccgagacc ggccggaccc ccatccccgc 241 ggccgccgcc gccgctggtc ccgcggctgc gaccgtggcg gctgccgctg gaaaatgtct 301 caggagaggc ccacgttcta ccggcaggag ctgaacaaga caatctggga ggtgcccgag 361 cgttaccaga acctgtctcc agtgggctct ggcgcctatg gctctgtgtg tgctgctttt 421 gacacaaaaa cggggttacg tgtggcagtg aagaagctct ccagaccatt tcagtccatc 481 attcatgcga aaagaaccta cagagaactg cggttactta aacatatgaa acatgaaaat 541 gtgattggtc cgttggacgt ttttacacct gcaaggtctc tggaggaatt caatgatgtg 601 tatctggtga cccatctcat gggggcagat ctgaacaaca ttgtgaaatg tcagaagctt 661 acagatgacc atgttcagtt ccttatctac caaattctcc gaggtctaaa gtatatacat 721 tcagctgaca taattcacag ggacctaaaa cctagtaatc tagctgtgaa tgaagactgt 781 gagctgaaga ttctggattt tggactggct cggcacacag atgatgaaat gacaggctac 841 gtggccacta ggtggtacag ggctcctgag atcatgctga actggatgca ttacaaccag 901 acagttgata tttggtcagt gggatgcata atggccgagc tgttgactgg aagaacattg 961 tttcctggta cagaccatat tgatcagttg aagctcattt taagactcgt tggaacccca 1021 ggggctgagc ttttgaagaa aatctcctca gagtctgcaa gaaactatat tcagtctttg 1081 actcagatgc cgaagatgaa ctttgcgaat gtatttattg gtgccaatcc cctggctgtc 1141 gacttgctgg agaagatgct tgtattggac tcagataaga gaattacagc ggcccaagcc 1201 cttgcacatg cctactttgc tcagtaccac gatcctgatg atgaaccagt ggccgatcct 1261 tatgatcagt cctttgaaag cagggacctc cttatagatg agtggaaaag cctgacctat 1321 gatgaagtca tcagctttgt gccaccaccc cttgaccaag aagagatgga gtcctgagca 1381 cctggtttct gttctgttga tcccacttca ctgtgagggg aaggcctttt cacgggaact 1441 ctccaaatat tattcaagtg cctcttgttg cagagatttc ctccatggtg gaagggggtg 1501 tgcgtgcgta tgcgtgcgtg ttagtgtgtg tgcatgtgt 1 tggttaacgc cagggttttc ccagtcacga acgttgtaaa acgacggcca gtgccaagct 61 aaaattaacc ttcactaaag ggaataagct tgcggccgct tcgggtttcc ggaggggccg 121 gagggcgggc gagggcgtca cgtgcgcgcc gcccgcgggc cggttggtcc ccgggcgggg 181 gaggggccgt gcgcagcctg ggtcggggtc gggccggggt cggcacctgg gacatccctg 241 agggaagggc cgggagcggg agcgccccag cggccggcgg gcgggcgggc gagcggacga 301 gcggcgcgga gccggcccga ggcgcgcgcc gagggagccc cgtccccggt cgtgggggca 361 ccgcccgcag gctctgcggg gtgggcagct cccgggcctg ccatgagctc tccgccgccc 421 gcccgcagtg gcttttaccg ccaggaggtg accaagacgg cctgggaggt gcgcgccgtg 481 taccgggacc tgcagcccgt gggctcgggc gcctacggcg cggtgtgctc ggccgtggac 541 ggccgcaccg gcgctaaggt ggccatcaag aagctgtatc ggcccttcca gtccgagctg 601 ttcgccaagc gcgcctaccg cgagctgcgc ctgctcaagc acatgcgcca cgagaacgtg 661 atcgggctgc tggacgtatt cactcctgat gagaccctgg atgacttcac ggacttttac 721 ctggtgatgc cgttcatggg caccgacctg ggcaagctca tgaaacarga gaagctaggc 781 gaggaccgga rccagttcct cgtgtaccag atgctgaagg ggctgaggta tatccacgct 841 gccggcatca tccacagaga cctgaagccc ggcaacctgg ctgtgaacga agactgtgag 901 ctgaagatcc tggacttcgg cctggccagg caggcagaca gtgagatgac tgggtacgtg 961 gtgacccggt ggtaccgggc tcccgaggtc atcttgaatt ggatgcgcta cacgcagacg 1021 gtggacatct ggtccgtggg ctgcatcatg gcggagatga tcacaggcaa gacgctgttc 1081 aagggcagcg accacctgga ccagctgaag gagatcatga aggtgacggg gacgcctccg 1141 gctgagtttg tgcagcggct gcagagcgat gaggccaaga acaacatgaa gggcctcccc 1201 gaattggaga agaaggattt tgcctctatc ctgaccaatg caagccctct ggctgtgaac 1261 ctcctggaga agatgctggt gctggacgcg gagcagcggg tgacggcagg cgaggcgctg 1321 gcccatccct acttcgagtc cctgcacgac acggaagatg agccccaggt ccagaagtat 1381 gatgactcct ttgacgacgt tgaccgcaca ctggatgaat ggaagcgtgt tacttacaaa 1441 gaggtgctca gcttcaagcc tccccggcag ctgggggcca gggtctccaa ggagacgcct 1501 ctgtgaagat ctctgggctc cggggtggca gtgaggacca ccttcacctt (2) INFORMATION FOR SEQ ID NO:2681: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2681 1 ctcgatcaaa cctttttttt atggtacaca atagtcacag tacttttcca tataaaacag 61 gtttagtggt cttaatttag tttggcacat ttaatacact cccatgacca gcatcccaaa 121 tgtacctatc cgttttattt tattgtctca gaattgtcag ttatttaata aattatgtaa 181 cttttttcct catgctcaga tttgcacttc tttctaaaac tctgcccatc cttaaagtcc 241 cagattctcc ttgaactttt ttttttgact ttccaagtac atggaactct tcactctatc 301 ctgctatata aggtgacaga atttccacta tgggatagat ggagttcaat tcctttgagt 361 ttaaaataat ctaaatataa ttattcctta tgccctgttt ttccctcact tttgtatcca 421 aatctctttt cagacaacag aacaattaat gtctgataag gaagacaatg atgatgatca 481 cttcaaaatg aattcaggat tgtaatgtaa aattttagta ctctctcaca gtatggattc WO 00/09525 PCT/US99/17712 EPI-109 890 541 taacatggct tctaacccaa actaacatta gtagctctaa ctataaactt caaatttcag 601 tagatgcaac ctactcc:tt aaaatgaaac agaagattga aattattaaa ttatcaaaaa 661 gaaaatgatc cacgctctta gttgaaattt catgtaagat tccatgcaat aaataggagt 721 gccataaatg gaatgatgaa atatgactag aggaggagaa aggctcctag atgagatggg 781 attttaggca tccgtgtctc atgaggaatc agttgtgtca ctaggcaaaa cagtaaaaaa 841 aaaaacctcc aagtgagtct cttatttatt tttttcttat aagacttcta caaattgagg 901 tacctggtgt agttttattt caggttttat gctgtcattt tcctgtaatg ctaaggactt 961 aggacataac tgaattttct attttccact tcttttctgg tgtgtgtgta tatatatatg 1021 tatatataca cacacacata tacatatata tattttttag tatctcaccc tcacatgctc 1081 ctccctgagc actacccatg atagatgtta aacaaaagca aagatgaaat tccaactgtc 1141 aaaatccccc ctccatctaa ttaatccctc acccaactat gttccaaaac gagaatagaa 1201 aattagcccc aataagccca ggcaactgaa aagtaaatgc tatgttgtac tttgatccat 1261 ggtcacaact cataatcttg gaaaagtgga cagaaaagac aaaagagtga actttaaaac 1321 tcgaatttat tttaccagta tctcctatga agggctagta accaaaataa tccacgcatc 1381 agggagagaa atgccttaag gcatacgttt tggacattta gcgtccctgc aaattctggc 1441 catcgccgct tcctttgtcc atcagaaggc aggaaacttt atattggtga cccgtggagc 1501 tcacattaac tatttacagg gtaactgctt aggaccagta ttatgaggag aatttacctt 1561 tcccgcctct ctttccaaga aacaaggagg gggtgaaggt acggagaaca gtatttcttc 1621 tgttgaaagc aacttagcta caaagataaa ttacagctat gtacactgaa ggtagctatt 1681 tcattccaca aaataagagt tttttaaaaa gctatgtatg tatgtgctgc atatagagca 1741 gatatacagc ctattaagcg tcgtcactaa aacataaaac atgtcagcct ttcttaacct 1801 tactcgcccc agtctgtccc gacgtgactt cctcgaccct ctaaagacgt acagaccaga 1861 cacggcggcg gcggcgggag aggggattcc ctgcggcccc ggacctcagg gccgctcaga 1921 ttcctggaga ggaagccaag tgtccttctg ccctcccccg gtatcccatc caaggcgatc 1981 agtccacaac tggctctcgg aagcactcgg gcaaagactg cgaagaagaa aagacatctg 2041 gcggaaacct gtgcgcctgg ggcggtggaa ctcggggagg agagggaggg atcagacagg 2101 agagtgggga ctaccccctc tgctcccaaa ttggggcagc ttcctgggtt tccgattttc 2161 tcatttccgt gggtaaaaaa ccctgccccc accggcttac gcaatttttt taaggggaga 2221 ggagggaaaa atttgtgggg ggtacgaaaa ggcggaaaga aacagtcatt tcgtcacatg 2281 ggcttggttt tcagtcttat aaaaaggaag gttctctcgg ttagcgacca attgtcatac 2341 gacttgcagt gagcgtcagg agcacgtcca ggaactcctc agcagcgcct ccttcagctc (2) INFORMATION FOR SEQ ID NO:2682: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2682 1 gtccaggaac tcctcagcag cgcctccttc agctccacag ccagacgccc tcagacagca 61 aagcctaccc ccgcgccgcg ccctgcccgc cgctgcgatg ctcgcccgcg ccctgctgct 121 gtgcgcggtc ctggcgctca gccatacagc aaatccttgc tgttcccacc catgtcaaaa 181 ccgaggtgta tgtatgagtg tgggatttga ccagtataag tgcgattgta cccggacagg 241 attctatgga gaaaactgct caacaccgga atttttgaca agaataaaat tatttctgaa 301 acccactcca aacacagtgc actacatact tacccacttc aagggatttt ggaacgttgt 361 gaataacatt cccttccttc gaaatgcaat tatgagttat gtgttgacat ccagatcaca 421 tttgattgac agtccaccaa cttacaatgc tgactatggc tacaaaagct gggaagcctt 481 ctctaacctc tcctattata ctagagccct tcctcctgtg cctgatgatt gcccgactcc 541 cttgggtgtc aaaggtaaaa agcagcttcc tgattcaaat gagattgtgg gaaaattgct 601 tctaagaaga aagttcatcc ctgatcccca gggctcaaac atgatgtttg cattctttgc 661 ccagcacttc acgcatcagt ttttcaagac agatcataag cgagggccag ctttcaccaa 721 cgggctgggc catggggtgg acttaaatca tatttacggt gaaactctgg ctagacagcg 781 taaactgcgc cttttcaagg atggaaaaat gaaatatcag ataattgatg gagagatgta 841 tcctcccaca gtcaaagata ctcaggcaga gatgatctac cctcctcaag tccctgagca 901 tctacggttt gctgtggggc aggaggtctt tggtctggtg cctggtctga tgatgtatgc 961 cacaatctgg ctgagggaac acaacagagt atgcgatgtg cttaaacagg agcatcctga 1021 atggggtgat gagcagttgt tccagacaag caggctaata ctgataggag agactattaa 1081 gattgtgatt gaagattatg tgcaacactt gagtggctat cacttcaaac tgaaatttga 1141 cccagaacta cttttcaaca aacaattcca gtaccaaaat cgtattgctg ctgaatttaa 1201 caccctctat cactggcatc cccttctgcc tgacaccttt caaattcatg accagaaata 1261 caactatcaa cagtttatct acaacaactc tatattgctg gaacatggaa ttacccagtt 1321 tgttgaatca ttcaccaggc aaattgctgg cagggttgct ggtggtagga atgttccacc 1381 cgcagtacag aaagtatcac aggcttccat tgaccagagc aggcagatga aataccagtc 1441 ttttaatgag taccgcaaac gctttatgct gaagccctat gaatcatttg aagaacttac 1501 aggagaaaag gaaatgtctg cagagttgga agcactctat ggtgacatcg atgctgtgga 1561 gctgtatcct gcccttctgg tagaaaagcc tcggccagat gccatctttg gtgaaaccat 1621 ggtagaagtt ggagcaccat tctccttgaa aggacttatg ggtaatgtta tatgttctcc 1681 tgcctactgg aagccaagca cttttggtgg agaagtgggt tttcaaatca tcaacactgc 1741 ctcaattcag tctctcatct gcaataacgt gaagggctgt ccctttactt cattcagtgt WO 00/09525 PCT/US99/17112 EPI-109 891 1801 tccagatcca gagctcatta aaacagtcac catcaatgca agttcttccc gctccggact 1861 agatgatatc aatcccacag tactactaaa agaacgttcg actgaactgt agaagtctaa 1921 tgatcatatt tatttattta tatgaaccat gtctattaat ttaattattt aataatattt 1981 atattaaact ccttatgtta cttaacatct tctgtaacag aagtcagtac tcctgttgcg 2041 gagaaaggag tcatacttgt gaagactttt atgtcactac tctaaagatt ttgctgttgc 2101 tgttaagttt ggaaaacagt ttttattctg ttttataaac cagagagaaa tgagttttga 2161 cgtcttttta cttgaatttc aacttatatt ataaggacga aagtaaagat gtttgaatac 2221 ttaaacacta tcacaagatg ccaaaatgct gaaagttttt acactgtcga tgtttccaat 2281 gcatcttcca tgatgcatta gaagtaacta atgtttgaaa ttttaaagta cttttgggta 2341 tttttctgtc atcaaacaaa acaggtatca gtgcattatt aaatgaatat ttaaattaga 2401 cattaccagt aatttcatgt ctacttttta aaatcagcaa tgaaacaata atttgaaatt 2461 tctaaattca tagggtagaa tcacctgtaa aagcttgttt gatttcttaa agttattaaa 2521 cttgtacata taccaaaaag aagctgtctt ggatttaaat ctgtaaaatc agatgaaatt 2581 ttactacaat tgcttgttaa aatattttat aagtgatgtt cctttttcac caagagtata 2641 aaccttttta gtgtgactgt taaaacttcc ttttaaatca aaatgccaaa tttattaagg 2701 tggtggagcc actgcagtgt tatctcaaaa taagaatatc ctgttgagat attccagaat 2761 ctgtttatat ggctggtaac atgtaaaaac cccataaccc cgccaaaagg ggtcctaccc 2821 ttgaacataa agcaataacc aaaggagaaa agcccaaatt attggttcca aatttagggt 2881 ttaaactttt tgaagcaaac ttttttttag ccttgtgcac tgcagacctg gtactcagat 2941 tttgctatga ggttaatgaa gtaccaagct gtgcttgaat aacgatatgt tttctcagat 3001 tttctgttgt acagtttaat ttagcagtcc atatcacatt gcaaaagtag caatgacctc 3061 ataaaatacc tcttcaaaat gcttaaattc atttcacaca ttaattttat ctcagtcttg 3121 aagccaattc agtaggtgca ttggaatcaa gcctggctac ctgcatgctg ttccttttct 3181 tttcttcttt tagccatttt gctaagagac acagtcttct caaacacttc gtttctccta 3241 ttttgtttta ctagttttaa gatcagagtt cactttcttt ggactctgcc tatattttct 3301 tacctgaact tttgcaagtt ttcaggtaaa cctcagctca ggactgctat ttagctcctc 3361 ttaagaagat taaaaaaaaa aaaaaag (2) INFORMATION FOR SEQ ID NO:2683: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2683 1 gagctcacat taactattta cagggtaact gcttaggacc agtattatga ggagaattta 61 cctttcccgc ctctctttcc aagaaacaag gagggggtga aggtacggag aacagtattt 121 cttctgttga aagcaactta gctacaaaga taaattacag ctatgtacac tgaaggtagc 181 tatttcattc cacaaaataa gagtttttta aaaagctatg tatgtatgtg ctgcatatag 241 agcagatata cagcctatta agcgtcgtca ctaaaacata aaacatgtca gcctttctta 301 accttactcg ccccagtctg tcccgacgtg acttcctcga ccctctaaag acgtacagac 361 cagacacggc ggcggcggcg ggagagggga ttccctgcgc ccccggacct cagggccgct 421 cagattcctg gagaggaagc caagtgtcct tctgccctcc cccggtatcc catccaaggc 481 gatcagtcca gaactggctc tcggaagcgc tcgggcaaag actgcgaaga agaaaagaca 541 tctggcggaa acctgtgcgc ctggggcggt ggaactcggg gaggagaggg agggatcaga 601 caggagagtg gggactacc'c cctctgctcc caaattgggg cagcttcctg ggtttccgat 661 tttctcattt ccgtgggtaa aaaaccctgc ccccaccggg cttacgcaat ttttttaagg 721 ggagaggagg gaaaaaattt gtgggggggt acgaaaaggc ggaaagaaac agtcattcac 781 atgggcttgg ttttcagtct tataaaaagg aaggttctct cggttagcga ccaattgtca 841 tacgacttgc agtgagcgtc aggagcacgt ccaggaactc ctcagcagcg cctccttcag 901 ctccacagcc agacgccctc agacagcaaa gcctaccccc gcgccgcgcc ctgcccgccg 961 ctcggatgct cgcccgcgcc ctgctgctgt gcgcggtcct ggcgctcagc catacaggtg 1021 agtacctggc gccgcgcacc ggggactccg gttccacgca cccgggcaga gtttccgctc 1081 tgacctcctg ggtctatccc agtactccga cttctctccg aatagagaag ctacgtgact 1141 tgggaaagag cttggaccgc tagagtccga aagaactccg tggatattcc agctttccca 1201 caagcactga tcattatgag ccagttactt aaccgatctg agacactctc acctcctaaa 1261 tagggataga tgatactaat ttgcaggttg tcattatgat aagacaggat ctgatcaata 1321 tatgtgaatt gtttatattt ggaacctttt tattgagtgg aagaagttgt tttaaatatt 1381 ctagtcagtt ctttcctgct cccaggaaag cccggattat gttttaagat aagcaaaatg 1441 tcttaaaagt aagctgtttt actttgaatt tttccctaaa tgttgattag tgtactagat 1501 ccattttaat ttggaaagtg aagtgctact tatttgaact tcttaaaaat gctaatttta 1561 acatctaaag agttaactaa gaaaagctta gtaacatgat gtaccaagtt gaatatgctg 1621 ttatccttat ttagaataga aaattggtat ttctacgttt tatccattct aaggcaggtt 1681 aaaaaattgt atttccatga ctacctatat atttcttgaa tttattattg taaagttgat 1741 tcatagtcaa acaattaaat gtttaaatta agattaagac actagagaat gatttatttg 1801 ctgtccttta attgcagcaa atccttgctg ttcccaccca tgtcaaaacc gaggtgtatg 1861 tatgagtgtg ggatttgacc agtataagtg cgattgtacc cggacaggat tctatggaga 1921 aaactgctca acacgtaagt ttgtcctttg gttgcctcat taggagtggg gctggataca 1981 gttatcattg tatagatttg tgtcttataa tgagtcccat taatttctcc ctccctttct WO 00/09525 PCT/US99/17712 EPI-109 892 2041 tcgtcttctt gcagcggaat ttttgacaag aataaaatta tttctgaaac ccactccaaa 2101 cacagtgcac tacatactta cccacttcaa gggattttgg aacgttgtga ataacattcc 2161 cttccttcga aatgcaatta tgagttatgt cttgacatgt aagtacaagt gtctttctaa 2221 ggtttttagc cttctcaaag aaaaatatgc tttataatac tgtaaaccta atctaaaaac 2281 atatttccaa gcttatcaaa aagactttaa gatagctttt aagtttzcct tccatcttaa 2341 tcgccaaaaa tattgacatt tagtcccatc cagtttatac agtctctca caactctgta 2401 tacctcttct aacctttact gtttggtcag tttgtggagg tagcatzgtc cagctgttta 2461 ttgaatgccc atgggccaca gaattgttct gaacatgtag cacccartaa aataaatttg 2521 gatttggatc agcaagaaaa taactttcca tgattctaaa gtgggtgcca tactcagcca 2581 ttcctttcat aggcctcttg gatagtgagc agatggctac ctgaaaaatc aatattgcca 2641 gattataatg tgcagagtat atgtatttta ttaaagatgt atttcaagtg gccattagac 2701 tataaagtgt agttgtttaa aaatagattt tttttatttt ggagttacat tcaacctcag 2761 gtgccacttt ccacatttta caataaaaat aatggttgat ttacttaaca aatgagaata 2821 aataaaacat ttttttcttt gaaaatttca gccagatcac atttgattga cagtccacca 2881 acttacaatg ctgactatgg ctacaaaagc tgggaagcct tctctaacct ctcctattat 2941 actagagccc ttcctcctgt gcctgatgat tgcccgactc ccttgggtgt caaaggtgag 3001 taagaagaat ccattagaga tgtattaact ataagacggg ctgcattgct gccaaaaaaa 3061 aaaattgacc ttagactacc atttatttat taacaaaagc agtttttact tttagcatgg 3121 ttatctatgg gtatttttta aagtatgagt ctatataaac tattatgtaa aagcaaatga 3181 gcgtcttggt ataatgtctt aatattttca aattatttct ttagaaatga aataattcta 3241 attaaaatag ataaaatcat tcagtaagaa gttgttccac catatcttag aactgttgtt 3301 tatattatga tcctattcac aattgtaatt ctcatataaa tgaagaattc ttggtagatt 3361 gacagtcacc atctcctttc ttgaatacat agatggattc ttacctragc tttctcattt 3421 ttcaggtaaa aagcagcttc ctgattcaaa tgagattgtg gaaaaattgc ttctaagaag 3481 aaagttcatc cctgatcccc agggctcaaa catgatgttt gcattctttg cccagcactt 3541 cacgcatcag tttttcaaga cagatcataa gcgagggcca gctttcacca acgggctggg 3601 ccatggggta agatagagtt aatatcttag agttagtaaa attataccaa atcatagtca 3661 agggctaaca ttaaaggaga tatacagata gatagatcca aataacttat ccactttttt 3721 taaaaagaag tcttatctat aaaaacctta aaggaatttt ccatttactt cactggtcta 3781 gtaaaattat acacacacac agacatgcac acacatatat aaacattcac acacatacat 3841 atgtacaggt attgttattt gtaatttgac ccttgtattt tttagtttaa aatgttagta 3901 ctgcaaaatg ttatgtcctc aaaaacacat tgtaccatga ttatgccgct ttcaatattg 3961 taaagtgagg tttttgccgc attattattt tttggatttc aatagcatag cttcaagtta 4021 ttcgtaagaa ttttttataa ataatacatt tttatacttt tttataatta ccatatcatc 4081 atagtgaagt atataatata tatgatataa gctcaatata gtatattaat tccgttaaac 4141 acaaagacat atcagtttgt agctttggtg gataaacaaa ttaatttagc aattcatggc 4201 tatgaaaaat gtatatttta tttaaaaatt ttaaagaaag ctaaatgatc aaattattta 4261 atgatgaatt atatgataga cactttatat aagaaaaact tcaacagcaa caaattaaaa 4321 ttttttcatc attttctagg tggacttaaa tcatatttac ggtgaaactc tggctagaca 4381 gcgtaaactg cgccttttca aggatggaaa aatgaaatat caggtatact tcctttgact 4441 attaagactt agttattacc gcttataccc atattttaaa atccctaaaa atgtgttcct 4501 taacttttta actgatgttt atttatttat ttattttttt agataaztga tggagagatg 4561 tatcctccca cagtcaaaga tactcaggca gagatgatct accctcctca agtccctgag 4621 catctacggt ttgctgtggg gcaggaggtc tttggtctgg tgcctgatct gatgatgtat 4681 gccacaatct ggctgcggga acacaacaga gtatgcgatg tgcttaaaca ggagcatcct 4741 gaatggggtg atgagcagtt gttccagaca agcaggctaa tactgatagg taaacaagaa 4801 aatgatttat ataaaaccct cttccccagg gaaaattagt gtgctatctt tgttatgttt 4861 tgagtaaatg acaagatgtg gtaaatgaaa actcacacat tctatataca ttaaatatgt 4921 aagcatgact gataaaatag ctatcttttg atactgacaa ggaagaaaac agaaatgaag 4981 gaatagcaaa ttttaaaaat tgcattccag ttgcttgaaa gcttgtgatc agatgcaata 5041 aatgttttta ttatttattt tgtgcaaata ggagagacta ttaagattgt gattgaagat 5101 tatgtgcaac acttgagtgg ctatcacttc aaactgaaat ttgacccaga actacttttc 5161 aacaaacaat tccagtacca aaatcgtatt gctgctgaat ttaacaccct ctatcactgg 5221 catccccttc tgcctgacac ctttcaaatt catgaccaga aatacaacta tcaacagttt 5281 atctacaaca actctatatt gctggaacat ggaattaccc agtttgttga atcattcacc 5341 aggcaaattg ctggcagggt aagcattatt attgaaaacc aaaacaaaag actagtcagt 5401 aactttagaa tttctgccac ggaaattatt tttcttaaac ttactaaaag agtagttagt 5461 tatattgcta gtaaaattat tttattgata taagaagcct aactttgttt gaaaagtcta 5521 aacttttagt ctagtctaca gttgtcagac aaatagcaaa ttgtacccct accttaaaaa 5581 tattttcaaa aagtatctat aatcttatag gaataaatat tttaggcttg aatactagtg 5641 ttatttttga aatgtaaaaa ggcaaattag ttctaggctg gtgtcccatt gaattttaag 5701 cagagctcct gttgaaatgt aggtaagcat ctttccagca aataaaaatt gtctccgctg 5761 ggagtttcag ttttacctga tttgtaccta aggcaagctg aatacaaaca gtaaatatgc 5821 ctaaaattct tgttttacaa ctaattttac tttccacagg ttgctggtgg taggaatgtt 5881 ccacccgcag tacagaaagt atcacaggct tccattgacc agagcaggca gatgaaatac 5941 cagtctttta atgagtaccg caaacgcttt atgctgaagc cctatgaatc atttgaagaa 6001 cttacaggta agaaacagtt tctaaacttc ttcgtttttt gtttgtztgt ttgtttttgt 6061 tgtttttggt uttcttttcg agatggagcc gccctctgtc acccaggctg gagtgcagtg WO 00/09525 PCT/US99/17712 EPI-109 893 6121 gcgccatctc ggctcactgc aacctccgcc tcctgggttc aagcaattct cctgcctcaa 6181 cttcctgagt agctgggact acaggctcac gtcgcacgca tggataattt tttgtatttt 6241 cagtatagac ggggtttcac cgtgttagcc aggctggtct caaactcctg acctagtgat 6301 ccgccggctt cggcctcccg aagtgctggg attacaggcg tgagccaccg cgcctggccc 6361 ctaaacttct taaaagaatc aggggtcaaa tggaaacaga gaagttggca gcaaattgag 6421 caaaagaatc aaactgtttt ttattttgtg aagtttgaca ttggttgtat ctctgtcttc 6481 atcgccttca caggagaaaa ggaaatgtct gcagagttgg aagcactcta tggtgacatc 6541 gatgctgtgg agctgtatcc tgcccttctg gtagaaaagc ctcggccaga tgccatcttt 6601 ggtgaaacca tggtagaagt tggagcacca ttctccttga aaggacttat gggtaatgtt 6661 atatgttctc ctgcctactg gaagccaagc acttttggtg gagaagtggg ttttcaaatc 6721 atcaacactg cctcaattca gtctctcatc tgcaataacg tgaagggctg tccctttact 6781 tcattcagtg ttccagatcc agagctcatt aaaacagtca ccatcaatgc aagttcttcc 6841 cgctccggac tagatgatat caatcccaca gtactactaa aagaacgttc gactgaactg 6901 tagaagtcta atgatcatat ttatttattt atatgaacca tgtctattaa tttaattatt 6961 taataatatt tatattaaac tccttatgtt acttaacatc ttctgtaaca gaagtcagta 7021 ctcctgttgc ggagaaagga gtcatacttg tgaagacttt tatgtcacta ctctaaagat 7081 tttgctgttg ctgttaagtt tggaaaacag tttttattct gttttataaa ccagagagaa 7141 atgagttttg acgtcttttt acttgaattt caacttatat tataagaacg aaagtaaaga 7201 tgtttgaata cttaaacact atcacaagat ggcaaaatgc tgaaagtttt tacactgtcg 7261 atgtttccaa tgcatcttcc atgatgcatt agaagtaact aatgtttgaa attttaaagt 7321 acttttggtt atttttctgt catcaaacaa aaacaggtat cagtgcatta ttaaatgaat 7381 atttaaatta gacattacca gtaatttcat gtctactttt taaaatcagc aatgaaacaa 7441 taatttgaaa tttctaaatt catagggtag aatcacctgt aaaagcttgt ttgatttctt 7501 aaagttatta aacttgtaca tataccaaaa agaagctgtc ttggatttaa atctgtaaaa 7561 tcagatgaaa ttttactaca attgcttgtt aaaatatttt ataagtgatg ttcctttttc 7621 accaagagta taaacctttt tagtgtgact gttaaaactt ccttttaaat caaaatgcca 7681 aatttattaa ggtggtggag ccactgcagt gttatctcaa aataagaata ttttgttgag 7741 atattccaga atttgtttat atggctggta acatgtaaaa tctatatcag caaaagggtc 7801 tacctttaaa ataagcaata acaaagaaga aaaccaaatt attgttcaaa tttaggttta 7861 aacttttgaa gcaaactttt ttttatcctt gtgcactgca ggcctggtac tcagattttg 7921 ctatgaggtt aatgaagtac caagctgtgc ttgaataacg atatgttttc tcagattttc 7981 tgttgtacag tttaatttag cagtccatat cacattgcaa aagtagcaat gacctcataa 8041 aatacctctt caaaatgctt aaattcattt cacacattaa ttttatctca gtcttgaagc 8101 caattcagta ggtgcattgg aatcaagcct ggctacctgc atgctgttcc ttttcttttc 8161 ttcttttagc cattttgcta agagacacag tcttctcatc acttcgtttc tcctattttg 8221 ttttactagt tttaagatca gagttcactt tctttggact ctgcctatat tttcttacct 8281 gaacttttgc aagttttcag gtaaacctca gctcaggact gctatttagc tcctcttaag 8341 aagattaaaa gagaaaaaaa aaggcccttt taaaaatagt atacacttat tttaagtgaa 8401 aagcagagaa ttttatttat agctaatttt agctatctgt aaccaagatg gatgcaaaga 8461 ggctagtgcc tcagagagaa ctgtacgggg tttgtgactg gaaaaagtta cgttcccatt 8521 ctaattaatg ccctttctta tttaaaaaca aaaccaaatg atatctaagt agttctcagc 8581 aataataata atgacgataa tacttctttt ccacatctca ttgtcactga catttaatgg 8641 tactgtatat tacttaattt attgaagatt attatttatg tcttattagg acactatggt 8701 tataaactgt gtttaagcct acaatcattg attttttttt gttatgtcac aatcagtata 8761 ttttctttgg ggttacctct ctgaatatta tgtaaacaat ccaaagaaat gattgtatta 8821 agatttgtga ataaattttt agaaatctga ttggcatatt gagatattta aggttgaatg 8881 tttgtcctta ggataggcct atgtgctagc ccacaaagaa tattgtctca ttagcctgaa 8941 tgtgccataa gactgacctt ttaaaatgtt ttgagggatc tgtggatgct tcgttaattt 9001 gttcagccac aatttattga gaaaatattc tgtgtcaagc actgtgggtt ttaatatttt 9061 taaatcaaac gctgattaca gataatagta tttatataaa taattgaaaa aaattttctt 9121 ttgggaagag ggagaaaatg aaataaatat cattaaagat aactcaggag aatcttcttt 9181 acaattttac gtttagaatg tttaaggtta agaaagaaat agtcaatatg cttgtataaa 9241 acactgttca ctgttttttt taaaaaaaaa acttgatttg ttattaacat tgatctgctg 9301 acaaaacctg ggaatttggg ttgtgtatgc gaatgtttca gtgcctcaga caaatgtgta 9361 tttaacttat gtaaaagata agtctggaaa taaatgtctg tttatttttg tactatttaa 9421 aaaaaaaaaa aaaaatcgat gtcgactcga gtc (2) INFORMATION FOR SEQ ID NO:2684: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2684 1 ctcgatcaaa cctttttttt atggtacaca atagtcacag tacttttcca tataaaacag 61 gtttagtggt cttaatttag tttggcacat ttaatacact cccatgacca gcatcccaaa 121 tgtacctatc cgttttattt tattgtctca gaattgtcag ttatttaata aattatgtaa 181 cttttttcct tatgctcaga tttgcacttc tttctaaaac tctgcccatc cttaaagtcc 241 cagattctcc ttgaactttt ttttttgact ttccaagtac atggaactct tcactctatc WO 00/09525 PCT/US99/17712 EPI-109 894 301 ctgctatata aggtgacaga atttccacta tgggatagat ggagttcaat tcctttgagt 361 ttaaaataat ctaaatazaa ttattcctta tgccctgttt ttccctcact tttgtatcca 421 aatctctttt cagacaacag aacaattaat gtctgataag gaagacaatg atgatgatca 481 cttcaaaatg aattcaaat tgtaatgtaa aattttagta ctctctcaca gtatggattc 541 taacatggct tctaacccaa actaacatta gtagctctaa ctataaactt caaatttcag 601 tagatgcaac ctactccttt aaaatgaaac agaagattga aattattaaa ttatcaaaaa 661 gaaaatgatc cacgctctra gttgaaattt catgtaagat tccatgcaat aaataggagt 721 gccataaatg gaatgatgaa atatgactag aggaggagaa aggctcctag atgagatggg 781 attttaggca tccgtgtctc atgaggaatc agttgtgtca ctaggcaaaa cagtaaaaaa 841 aaaaacctcc aagtgagzct cttatttatt tttttcttat aagacttcta caaattgagg 901 tacctggtgt agttttaztt caggttttat gctgtcattt tcctgtaatg ctaaggactt 961 aggacataac tgaattttct attttccact tcttttctgg tgtgtgtgta tatatatatg 1021 tatatataca cacacacata tacatatata tattttttag tatctcaccc tcacatgctc 1081 ctccctgagc actacccatg atagatgtta aacaaaagca aagatgaaat tccaactgtc 1141 aaaatccccc ctccatctaa ttaatccctc acccaactat gttccaaaac gagaatagaa 1201 aattagcccc aataagccca ggcaactgaa aagtaaatgc tatgttgtac tttgatccat 1261 ggtcacaact cataatcttg gaaaagtgga cagaaaagac aaaagagtga actttaaaac 1321 tcgaatttat tttaccagta tctcctatga agggctagta accaaaataa tccacgcatc 1381 agggagagaa atgccttaag gcatacgttt tggacattta gcgtccctgc aaattctggc 1441 catcgccgct tcctttatcc atcagaaggc aggaaacttt atattggtga cccgtggagc 1501 tcacattaac tatttacagg gtaactgctt aggaccagta ttatgaggag aatttacctt 1561 tcccgcctct ctttccaaga aacaaggagg gggtgaaggt acggagaaca gtatttcttc 1621 tgttgaaagc aacttagcta caaagataaa ttacagctat gtacactgaa ggtagctatt 1681 tcattccaca aaataagagt tttttaaaaa gctatgtatg tatgtgctgc atatagagca 1741 gatatacagc ctattaaacg tcgtcactaa aacataaaac atgtcagcct ttcttaacct 1801 tactcgcccc agtctgtccc gacgtgactt cctcgaccct ctaaagacgt acagaccaga 1861 cacggcggcg gcggcgggag aggggattcc ctgcggcccc ggacctcagg gccgctcaga 1921 ttcctggaga ggaagccaag tgtccttctg ccctcccccg gtatcccatc caaggcgatc 1981 agtccacaac tggctctcgg aagcactcgg gcaaagactg cgaagaagaa aagacatctg 2041 gcggaaacct gtgcgcctgg ggcggtggaa ctcggggagg agagggaggg atcagacagg 2101 agagtgggga ctaccccctc tgctcccaaa ttggggcagc ttcctgggtt tccgattttc 2161 tcatttccgt gggtaaaaaa ccctgccccc accggcttac gcaatttttt taaggggaga 2221 ggagggaaaa atttgtgggg ggtacgaaaa ggcggaaaga aacagtcatt tcgtcacatg 2281 ggcttggttt tcagtcttat aaaaaggaag gttctctcgg ttagcgacca attgtcatac 2341 gacttgcagt gagcgtcagg agcacgtcca ggaactcctc agcagcgcct ccttcagctc 1 gtccaggaac tcctcagcag cgcctccttc agctccacag ccagacgccc tcagacagca 61 aagcctaccc ccgcgccgcg ccctgcccgc cgctgcgatg ctcgcccgcg ccctgctgct 121 gtgcgcggtc ctggcgctca gccatacagc aaatccttgc tgttcccacc catgtcaaaa 181 ccgaggtgta tgtatgagtg tgggatttga ccagtataag tgcgattgta cccggacagg 241 attctatgga gaaaactgct caacaccgga atttttgaca agaataaaat tatttctgaa 301 acccactcca aacacagtgc actacatact tacccacttc aagggatttt ggaacgttgt 361 gaataacatt cccttccttc gaaatgcaat tatgagttat gtgttgacat ccagatcaca 421 tttgattgac agtccaccaa cttacaatgc tgactatggc tacaaaagct gggaagcctt 481 ctctaacctc tcctattata ctagagccct tcctcctgtg cctgatgatt gcccgactcc 541 cttgggtgtc aaaggtaaaa agcagcttcc tgattcaaat gagattgtgg gaaaattgct 601 tctaagaaga aagttcatcc ctgatcccca gggctcaaac atgatgtttg cattctttgc 661 ccagcacttc acgcatcagt ttttcaagac agatcataag cgagggccag ctttcaccaa 721 cgggctgggc catggggtgg acttaaatca tatttacggt gaaactctgg ctagacagcg 781 taaactgcgc cttttcaagg atggaaaaat gaaatatcag ataattgatg gagagatgta 841 tcctcccaca gtcaaagata ctcaggcaga gatgatctac cctcctcaag tccctgagca 901 tctacggttt gctgtggggc aggaggtctt tggtctggtg cctggtctga tgatgtatgc 961 cacaatctgg ctgagggaac acaacagagt atgcgatgtg cttaaacagg agcatcctga 1021 atggggtgat gagcagttgt tccagacaag caggctaata ctgataggag agactattaa 1081 gattgtgatt gaagattatg tgcaacactt gagtggctat cacttcaaac tgaaatttga 1141 cccagaacta cttttcaaca aacaattcca gtaccaaaat cgtattgctg ctgaatttaa 1201 caccctctat cactggcatc cccttctgcc tgacaccttt caaattcatg accagaaata 1261 caactatcaa cagtttatct acaacaactc tatattgctg gaacatggaa ttacccagtt 1321 tgttgaatca ttcaccaggc aaattgctgg cagggttgct ggtggtagga atgttccacc 1381 cgcagtacag aaagtatcac aggcttccat tgaccagagc aggcagatga aataccagtc 1441 ttttaatgag taccgcaaac gctttatgct gaagccctat gaatcatttg aagaacttac 1501 aggagaaaag gaaatgtctg cagagttgga agcactctat ggtgacatcg atgctgtgga 1561 gctgtatcct gcccttctgg tagaaaagcc tcggccagat gccatctttg gtgaaaccat 1621 ggtagaagtt ggagcaccat tctccttgaa aggacttatg ggtaatgtta tatgttctcc 1681 tgcctactgg aagccaagca cttttggtgg agaagtgggt tttcaaatca tcaacactgc 1741 ctcaattcag tctctcatct gcaataacgt gaagggctgt ccctttactt cattcagtgt 1801 tccagatcca gagctcatta aaacagtcac catcaatgca agttcttccc gctccggact 1861 agatgatatc aatcccacag tactactaaa agaacgttcg actgaactgt agaagtctaa 1921 tgatcatatt tatttattta tatgaaccat gtctattaat ttaattattt aataatattt WO 00/09525 PCTIUS99/1 7712 EPI-109 895 1981 atattaaact ccttatgtta cttaacatct tctgtaacag aagtcagtac tcctgttgcg 2041 gagaaaggag tcatacttgt gaagactttt atgtcactac tctaaagatt ttgctgttgc 2101 tgttaagttt ggaaaacagt ttttattctg ttttataaac cagagagaaa tgagttttga 2161 cgtcttttta cttgaatttc aacttatatt ataaggacga aagtaaagat gtttgaatac 2221 ttaaacacta tcacaagatg ccaaaatgct gaaagttttt acactgtcga tgtttccaa 2281 gcatcttcca tgatgcatta gaagtaacta atgtttgaaa ttttaaagta cttttgggta 2341 tttttctgtc atcaaacaaa acaggtatca gtgcattatt aaatgaatat ttaaattaga 2401 cattaccagt aatttcatgt ctacttttta aaatcagcaa tgaaacaata atttgaaatt 2461 tctaaattca tagggtagaa tcacctgtaa aagcttgttt gatttcttaa agttattaaa 2521 cttgtacata taccaaaaag aagctgtctt ggatttaaat ctgtaaaatc agatgaaatt 2581 ttactacaat tgcttgttaa aatattttat aagtgatgtt cctttttcac caagagtata 2641 aaccttttta gtgtgactgt taaaacttcc ttttaaatca aaatgccaaa tttattaagg 2701 tggtggagcc actgcagtgt tatctcaaaa taagaatatc ctgttgagat attccagaat 2761 ctgtttatat ggctggtaac atgtaaaaac cccataaccc cgccaaaagg ggtcctaccc 2821 ttgaacataa agcaataacc aaaggagaaa agcccaaatt attggttcca aatttagggt 2881 ttaaactttt tgaagcaaac ttttttttag ccttgtgcac tgcagacctg gtactcagat 2941 tttgctatga ggttaatgaa gtaccaagct gtgcttgaat aacgatatgt tttctcagat 3001 tttctgttgt acagtttaat ttagcagtcc atatcacatt gcaaaagtag caatgacctc 3061 ataaaatacc tcttcaaaat gcttaaattc atttcacaca ttaattttat ctcagtcttg 3121 aagccaattc agtaggtgca ttggaatcaa gcctggctac ctgcatgctg ttccttttct 3181 tttcttcttt tagccatttt gctaagagac acagtcttct caaacacttc gtttctccta 3241 ttttgtttta ctagttttaa gatcagagtt cactttcttt ggactctgcc tatattttct 3301 tacctgaact tttgcaagtt ttcaggtaaa cctcagctca ggactgctat ttagctcctc 3361 ttaagaagat taaaaaaaaa aaaaaag 1 gagctcacat taactattta cagggtaact gcttaggacc agtattatga ggagaattta 61 cctttcccgc ctctctttcc aagaaacaag gagggggtga aggtacggag aacagtattt 121 cttctgttga aagcaactta gctacaaaga taaattacag ctatgtacac tgaaggtagc 181 tatttcattc cacaaaataa gagtttttta aaaagctatg tatgtatgtg ctgcatatag 241 agcagatata cagcctatta agcgtcgtca ctaaaacata aaacatgtca gcctttctta 301 accttactcg ccccagtctg tcccgacgtg acttcctcga ccctctaaag acgtacagac 361 cagacacggc ggcggcggcg ggagagggga ttccctgcgc ccccggacct cagggccgct 421 cagattcctg gagaggaagc caagtgtcct tctgccctcc cccggtatcc catccaaggc 481 gatcagtcca gaactggctc tcggaagcgc tcgggcaaag actgcgaaga agaaaagaca 541 tctggcggaa acctgtgcgc ctggggcggt ggaactcggg gaggagaggg agggatcaga 601 caggagagtg gggactaccc cctctgctcc caaattgggg cagcttcctg ggtttccgat 661 tttctcattt ccgtgggtaa aaaaccctgc ccccaccggg cttacgcaat ttttttaagg 721 ggagaggagg gaaaaaattt gtgggggggt acgaaaaggc ggaaagaaac agtcattcac 781 atgggcttgg ttttcagtct tataaaaagg aaggttctct cggttagcga ccaattgtca 841 tacgacttgc agtgagcgtc aggagcacgt ccaggaactc ctcagcagcg cctccttcag 901 ctccacagcc agacgccctc agacagcaaa gcctaccccc gcgccgcgcc ctgcccgccg 961 ctcggatgct cgcccgcgcc ctgctgctgt gcgcggtcct ggcgctcagc catacaggtg 1021 agtacctggc gccgcgcacc ggggactccg gttccacgca cccgggcaga gtttccgctc 1081 tgacctcctg ggtctatccc agtactccga cttctctccg aatagagaag ctacgtgact 1141 tgggaaagag cttggaccgc tagagtccga aagaactccg tggatattcc agctttccca 1201 caagcactga tcattatgag ccagttactt aaccgatctg agacactctc acctcctaaa 1261 tagggataga tgatactaat ttgcaggttg tcattatgat aagacaggat ctgatcaata 1321 tatqtgaatt gtttatattt ggaacctttt tattgagtgg aagaagttgt tttaaatatt 1381 ctagtcagtt ctttcctgct cccaggaaag cccggattat gttttaagat aagcaaaatg 1441 tcttaaaagt aagctgtttt actttgaatt tttccctaaa tgttgattag tgtactagat 1501 ccattttaat ttggaaagtg aagtgctact tatttgaact tcttaaaaat gctaatttta 1561 acatctaaag agttaactaa gaaaagctta gtaacatgat gtaccaagtt gaatatgctg 1621 ttatccttat ttagaataga aaattggtat ttctacgttt tatccattct aaggcaggtt 1681 aaaaaattgt atttccatga ctacctatat atttcttgaa tttattattg taaagttgat 1741 tcatagtcaa acaattaaat gtttaaatta agattaagac actagagaat gatttatttg 1801 ctgtccttta attgcagcaa atccttgctg ttcccaccca tgtcaaaacc gaggtgtatg 1861 tatgagtgtg ggatttgacc agtataagtg cgattgtacc cggacaggat tctatggaga 1921 aaactgctca acacgtaagt ttgtcctttg gttgcctcat taggagtggg gctggataca 1981 gttatcattg tatagatttg tgtcttataa tgagtcccat taatttctcc ctccctttct 2041 tcgtcttctt gcagcggaat ttttgacaag aataaaatta tttctgaaac ccactccaaa 2101 cacagtgcac tacatactta cccacttcaa gggattttgg aacgttgtga ataacattcc 2161 cttccttcga aatgcaatta tgagttatgt cttgacatgt aagtacaagt gtctttctaa 2221 ggtttttagc cttctcaaag aaaaatatgc tttataatac tgtaagccta atctaaaaac 2281 atatttccaa gcttatcaaa aagactttaa gatagctttt aagtttgcct tccatcttaa 2341 tcgccaaaaa tattgacatt tagtcccatc cagtttatac agtctgctca caactctgta 2401 tacctcttct aacctttact gtttggtcag tttgtggagg tagcatggtc cagctgttta 2461 ttgaatgccc atgggccaca gaattgttct gaacatatag cacccattaa aataaatttg 2521 gatttggatc agcaagaaaa taactttcca tgattctaaa gtgggtgcca tactcagcca 2581 ttcctttcat aggcctcttg gatagtgagc agatggctac ctgaaaaatc aatattgcca WO 00/09525 PCT/US99/17712 EPI-109 896 2641 gattataatg tgcagagtat atgtatttta ttaaagatgt atttcaagtg gccattagac 2701 tataaagtgt agttgtttaa aaatagattt tttttatttt ggagttacat tcaacctcag 2761 gtgccacttt ccacatttta caataaaaat aatggttgat ttacttaaca aatgagaata 2821 aataaaacat ttttttcttt gaaaatttca gccagatcac atttgattga cagtccacca 2881 acttacaatg ctgactatgg ctacaaaagc tgggaagcct tctctaacct ctcctattat 2941 actagagccc ttcctcctgt gcctgatgat tgcccgactc ccttgggtgt caaaggtgag 3001 taagaagaat ccattagaga tgtattaact ataagacggg ctgcattgct gccaaaaaaa 3061 aaaattgacc ttagactacc atttatttat taacaaaagc agtttttact tttagcatgg 3121 ttatctatgg gtatttttta aagtatgagt ctatataaac tattatgtaa aagcaaatga 3181 gcgtcttggt ataatgtctt aatattttca aattatttct ttagaaatga aataattcta 3241 attaaaatag ataaaatcat tcagtaagaa gttgttccac catatcttag aactgttgtt 3301 tatattatga tcctattcac aattgtaatt ctcatataaa tgaagaattc ttggtagatt 3361 gacagtcacc atctcctttc ttgaatacat agatggattc ttaccttagc tttctcattt 3421 ttcaggtaaa aagcagcttc ctgattcaaa tgagattgtg gaaaaattgc ttctaagaag 3481 aaagttcatc cctgatcccc agggctcaaa catgatgttt gcattctttg cccagcactt 3541 cacgcatcag tttttcaaga cagatcataa gcgagggcca gctttcacca acgggctggg 3601 ccatggggta agatagagtt aatatcttag agttagtaaa attataccaa atcatagtca 3661 agggctaaca ttaaaggaga tatacagata gatagatcca aataacttat ccactttttt 3721 taaaaagaag tcttatctat aaaaacctta aaggaatttt ccatttactt cactggtcta 3781 gtaaaattat acacacacac agacatgcac acacatatat aaacattcac acacatacat 3841 atgtacaggt attgttattt gtaatttgac ccttgtattt tttagtttaa aatgttagta 3901 ctgcaaaatg ttatgtcctc aaaaacacat tgtaccatga ttatgccgct ttcaatattg 3961 taaagtgagg tttttgccgc attattattt tttggatttc aatagcatag cttcaagtta 4021 ttcgtaagaa ttttttataa ataatacatt tttatacttt tttataatta ccatatcatc 4081 atagtgaagt atataatata tatgatataa gctcaatata gtatattaat tccgttaaac 4141 acaaagacat atcagtttgt agctttggtg gataaacaaa ttaatttagc aattcatggc 4201 tatgaaaaat gtatatttta tttaaaaatt ttaaagaaag ctaaatgatc aaattattta 4261 atgatgaatt atatgataga cactttatat aagaaaaact tcaacagcaa caaattaaaa 4321 ttttttcatc attttctagg tggacttaaa tcatatttac ggtgaaactc tggctagaca 4381 gcgtaaactg cgccttttca aggatggaaa aatgaaatat caggtatgct tcctttgact 4441 attaagactt agttattacc gcttataccc atattttaaa atccctaaaa atgtgttcct 4501 taacttttta actgatgttt atttatttat ttattttttt agataattga tggagagatg 4561 tatcctccca cagtcaaaga tactcaggca gagatgatct accctcctca agtccctgag 4621 catctacggt ttgctgtggg gcaggaggtc tttggtctgg tgcctggtct gatgatgtat 4681 gccacaatct ggctgcggga acacaacaga gtatgcgatg tgcttaaaca ggagcatcct 4741 gaatggggtg atgagcagtt gttccagaca agcaggctaa tactgatagg taaacaagaa 4801 aatgatttat ataaaaccct cttccccagg gaaaattagt gtgctatctt tgttatgttt 4861 tgagtaaatg acaagatgtg gtaaatgaaa actcacacat tctatataca ttaaatatgt 4921 aagcatgact gataaaatag ctatcttttg atactgacaa ggaagaaaac agaaatgaag 4981 gaatagcaaa ttttaaaaat tgcattccag ttgcttgaaa gcttgtgatc agatgcaata 5041 aatgttttta ttatttattt tgtgcaaata ggagagacta ttaagattgt gattgaagat 5101 tatgtgcaac acttgagtgg ctatcacttc aaactgaaat ttgacccaga actacttttc 5161 aacaaacaat tccagtacca aaatcgtatt gctgctgaat ttaacaccct ctatcactgg 5221 catccccttc tgcctgacac ctttcaaatt catgaccaga aatacaacta tcaacagttt 5281 atctacaaca actctatatt gctggaacat ggaattaccc agtttgttga atcattcacc 5341 aggcaaattg ctggcagggt aagcattatt attgaaaacc aaaacaaaag actagtcagt 5401 aactttagaa tttctgccac ggaaattatt tttcttaaac ttactaaaag agtagttagt 5461 tatattgcta gtaaaattat tttattgata taagaagcct aactttgttt gaaaagtcta 5521 aacttttagt ctagtctaca gttgtcagac aaatagcaaa ttgtacccct accttaaaaa 5581 tattttcaaa aagtatctat aatcttatag gaataaatat tttaggcttg aatactagtg 5641 ttatttttga aatgtaaaaa ggcaaattag ttctaggctg gtgtcccatt gaattttaag 5701 cagagctcct gttgaaatgt aggtaagcat ctttccagca aataaaaatt gtctccgctg 5761 ggagtttcag ttttacctga tttgtaccta aggcaagctg aatacaaaca gtaaatatgc 5821 ctaaaattct tgttttacaa ctaattttac tttccacagg ttgctggtgg taggaatgtt 5881 ccacccgcag tacagaaagt atcacaggct tccattgacc agagcaggca gatgaaatac 5941 cagtctttta atgagtaccg caaacgcttt atgctgaagc cctatgaatc atttgaagaa 6001 cttacaggta agaaacagtt tctaaacttc ttcgtttttt gtttgtttgt ttgtttttgt 6061 tgtttttggt tttcttttcg agatggagcc gccctctgtc acccaggctg gagtgcagtg 6121 gcgccatctc ggctcactgc aacctccgcc tcctgggttc aagcaattct cctgcctcaa 6181 cttcctgagt agctgggact acaggctcac gtcgcacgca tggataattt tttgtatttt 6241 cagtatagac ggggtttcac cgtgttagcc aggctggtct caaactcctg acctagtgat 6301 ccgccggctt cggcctcccg aagtgctggg attacaggcg tgagccaccg cgcctggccc 6361 ctaaacttct taaaagaatc aggggtcaaa tggaaacaga gaagttggca gcaaattgag 6421 caaaagaatc aaactgtttt ttattttgtg aagtttgaca ttggttgtat ctctgtcttc 6481 atcgccttca caggagaaaa ggaaatgtct gcagagttgg aagcactcta tggtgacatc 6541 gatgctgtgg agctgtatcc tgcccttctg gtagaaaagc ctcggccaga tgccatcttt 6601 ggtgaaacca zggtagaagt tggagcacca ttctccttga aaggacttat gggtaatgtt 6661 atatgttctc ctgcctactg gaagccaagc acttttggtg gagaagtggg ttttcaaatc WO 00/09525 PCT/US99/17712 EPI-109 897 6721 atcaacactg cctcaattca gtctctcatc tgcaataacg tgaagggctg tccctttact 6781 tcattcagtg ttccagatcc agagctcatt aaaacagtca ccatcaatgc aagttcttcc 6841 cgctccggac tagatgatat caatcccaca gtactactaa aagaacgttc gactgaactg 6901 tagaagtcta atgatcatat ttatttattt atatgaacca tgtctattaa tttaattatt 6961 taataatatt tatattaaac tccttatgtt acttaacatc ttctgtaaca gaagtcagta 7021 ctcctgttgc ggagaaagga gtcatacttg tgaagacttt tatgtcacta ctctaaagat 7081 tttgctgttg ctgttaagtt tggaaaacag tttttattct gttttataaa ccagagagaa 7141 atgagttttg acgtcttttt acttgaattt caacttatat tataagaacg aaagtaaaga 7201 tgtttgaata cttaaacact atcacaagat ggcaaaatgc tgaaagtttt tacactgtcg 7261 atgtttccaa tgcatcttcc atgatgcatt agaagtaact aatgtttgaa attttaaagt 7321 acttttggtt atttttctgt catcaaacaa aaacaggtat cagtgcatta ttaaatgaat 7381 atttaaatta gacattacca gtaatttcat gtctactttt taaaatcagc aatgaaacaa 7441 taatttgaaa tttctaaatt catagggtag aatcacctgt aaaagcttgt ttgatttctt 7501 aaagttatta aacttgtaca tataccaaaa agaagctgtc ttggatttaa atctgtaaaa 7561 tcagatgaaa ttttactaca attgcttgtt aaaatatttt ataagtgatg ttcctttttc 7621 accaagagta taaacctttt tagtgtgact gttaaaactt ccttttaaat caaaatgcca 7681 aatttattaa ggtggtggag ccactgcagt gttatctcaa aataagaata ttttgttgag 7741 atattccaga atttgtttat atggctggta acatgtaaaa tctatatcag caaaagggtc 7801 tacctttaaa ataagcaata acaaagaaga aaaccaaatt attgttcaaa tttaggttta 7861 aacttttgaa gcaaactttt ttttatcctt gtgcactgca ggcctggtac tcagattttg 7921 ctatgaggtt aatgaagtac caagctgtgc ttgaataacg atatgttttc tcagattttc 7981 tgttgtacag tttaatttag cagtccatat cacattgcaa aagtagcaat gacctcataa 8041 aatacctctt caaaatgctt aaattcattt cacacattaa ttttatctca gtcttgaagc 8101 caattcagta ggtgcattgg aatcaagcct ggctacctgc atgctgttcc ttttcttttc 8161 ttcttttagc cattttgcta agagacacag tcttctcatc acttcgtttc tcctattttg 8221 ttttactagt tttaagatca gagttcactt tctttggact ctgcctatat tttcttacct 8281 gaacttttgc aagttttcag gtaaacctca gctcaggact gctatttagc tcctcttaag 8341 aagattaaaa gagaaaaaaa aaggcccttt taaaaatagt atacacttat tttaagtgaa 8401 aagcagagaa ttttatttat agctaatttt agctatctgt aaccaagatg gatgcaaaga 8461 ggctagtgcc tcagagagaa ctgtacgggg tttgtgactg gaaaaagtta cgttcccatt 8521 ctaattaatg ccctttctta tttaaaaaca aaaccaaatg atatctaagt agttctcagc 8581 aataataata atgacgataa tacttctttt ccacatctca ttgtcactga catttaatgg 8641 tactgtatat tacttaattt attgaagatt attatttatg tcttattagg acactatggt 8701 tataaactgt gtttaagcct acaatcattg attttttttt gttatgtcac aatcagtata 8761 ttttctttgg ggttacctct ctgaatatta tgtaaacaat ccaaagaaat gattgtatta 8821 agatttgtga ataaattttt agaaatctga ttggcatatt gagatattta aggttgaatg 8881 tttgtcctta ggataggcct atgtgctagc ccacaaagaa tattgtctca ttagcctgaa 8941 tgtgccataa gactgacctt ttaaaatgtt ttgagggatc tgtggatgct tcgttaattt 9001 gttcagccac aatttattga gaaaatattc tgtgtcaagc actgtgggtt ttaatatttt 9061 taaatcaaac gctgattaca gataatagta tttatataaa taattgaaaa aaattttctt 9121 ttgggaagag ggagaaaatg aaataaatat cattaaagat aactcaggag aatcttcttt 9181 acaattttac gtttagaatg tttaaggtta agaaagaaat agtcaatatg cttgtataaa 9241 acactgttca ctgttttttt taaaaaaaaa acttgatttg ttattaacat tgatctgctg 9301 acaaaacctg ggaatttggg ttgtgtatgc gaatgtttca gtgcctcaga caaatgtgta 9361 tttaacttat gtaaaagata agtctggaaa taaatgtctg tttatttttg tactatttaa 9421 aaaaaaaaaa aaaaatcgat gtcgactcga gtc (2) INFORMATION FOR SEQ ID NO:2685: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2685 1 gaattccgga gttccgggcg cgcgcgacgt cagtttgagt tctgtgttct ccccgcccgt 61 gtcccgcccg acccgcgccc gcgatgctgg cgctgcgctg cggctcccgc tggctcggcc 121 tgctctccgz cccgcgctcc gtgccgctgc gcctccccgc ggcccgcgcc tgcagcaagg 181 gctccggcga cccgtcctct tcctcctcct ccgggaaccc gctcgtgtac ctggacgtgg 241 acgccaacgg gaagccgctc ggccgcgtgg tgctggagct gaaggcagat gtcgtcccaa 301 agacagctga gaacttcaga gccctgtgca ctggtgagaa gggcttcggc tacaaaggct 361 ccaccttcca cagggtgatc ccttccttca tgtgccaggc gggcgacttc accaaccaca 421 atggcacagg cgggaagtcc atctacggaa gccgctttcc tgacgagaac tttacactga 481 agcacgtggg gccaggtgtc ctgtccatgg ctaatgctgg tcctaacacc aacggctccc 541 agttcttcat ctgcaccata aagacagact ggttggatgg caagcatgtt gtgttcggtc 601 acgtcaaaga gggcatggac gtcgtgaaga aaatagaatc tttcggctct aagagtggga 661 ggacatccaa gaagattgtc atcacagact gtggccagtt gagctaatct gtggccaggg 721 tgctggcatg gtggcagctg caaatgtcca tgcacccagg tggccgcgtt gggctgtcag 781 ccaaggtgcc tgaaacgata cgtgtgccca ctccactgtc acagtgtgcc tgaggaaggc WO 00/09525 PCT/US99/17712 EPI-109 898 841 tgctagggat gttagacgga attcc (2) INFORMATION FOR SEQ ID NO:2686: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2686 1 ttttgcagac gccaccgccg aggaaaaccg tgtactatta gccatggtc (2) INFORMATION FOR SEQ ID NO:2687: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2687 1 cgggaacgca acatgaaggt gctccttgcc gccgccctca tcgcggggtc cgtcttcttc 61 ctgctgctgc cgggaccttc tgcggccgat gagaagaaga aggggcccaa agtcaccgtc 121 aaggtgtatt ttgacctacg aattggagat gaagatgtag gccgggtgat ctttggtctc 181 ttcggaaaga ctgttccaaa aacagtggat aattttgtgg ccttagctac aggagagaaa 241 ggatttggct acaaaaacag caaattccat cgtgtaatca aggacttcat gatccagggc 301 ggagacttca ccaggggaga tggcacagga ggaaagagca tctacggtga gcgcttcccc 361 gatgagaact tcaaactgaa gcactacggg cctggctggg tcagcatggc caacgcaggc 421 aaagacacca acggctccca gttcttcatc acgacagtca agacagcctg gctagatggc 481 aagcatgtgg tgtttggcaa agttctagag ggcatggagg tggtgcggaa ggtggagagc 541 accaagacag acagccggga taaacccctg aaggatgtga tcatcgcaga ctgcggcaag 601 atcgaggtgg agaagccctt tgccatcgcc aaggagtagg gcacagggac atctttcttt 661 gagtgaccgt ctgtgcaggc cctgtagtcc gccacagggc tctgagctgc actggccccg 721 gtgctggcat ctggtggagc ggacccactc ccctcacatt ccacaggccc atggactcac 781 ttttgtaaca aactcctacc aacactgacc aataaaaaaa aatgtgggtt tttttttttt 841 ttaataaaaa a (2) INFORMATION FOR SEQ ID NO:2688: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2688 1 gaaggtgctc cttgccgccg ccctcatcgc ggggtccgtc ttcttcctgc tgctgccggg 61 accttctgcg gccgatgaga agaagaaggg gcccaaagtc accgtcaagg tgtattttga 121 cctacgaatt ggagatgaag atgtaggccg ggtgatcttt ggtctctttg gaaagactgt 181 tccaaaaaca gtggataatt ttgtggcctt agctacagga gagaaaggat ttggctacaa 241 aaacagcaaa ttccatcgtg taatcaagga cttcatgatc cagggcggag acttcaccag 301 gggagatggc acaggaggaa agagcatcta cggtgagcgc ttccccgatg agaacttcaa 361 actgaagcac tacgggcctg gctgggtgag catggccaac gcaggcaaag acaccaacgg 421 ctcccagttc ttcatcacga cagtcaagac agcctggcta gatggcaagc atgtggtgtt 481 tggcaaagtt ctagagggca tggaggtggt gcggaaggtg gagagcacca agacagacag 541 ccgggataaa cccctgaagg atgtgatcat cgcagactgc ggcaagatcg aggtggagaa 601 gccctttgcc atcgccaagg agtagggcac agggacatct ttctttgagt gaccgtctgt 661 gcaggccctg tagtccgcca cagggctctg agctgcactg gccccggtgc tggcatctgg 721 tggagcggac ccactcccct cacattccac aggcccatgg actcactttt gtaacaaact 781 cctaccaaca ctgaccaaca aaaaaaaacg tgggtttttt tttttaataa aag (2) INFORMATION FOR SEQ ID NO:2689: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: base pairs (H) TYPE: nucleic acid (C) STRANDEDNESS: single (D0) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2689 1 gaattccctt gtaaggtttt cgtaacaaaa caccagtcac ataagtgcat tttattttat 61 atttttgttt atttatttga gacggagtct cttgtctctc aggctggagt gcagtggcgc 121 catctctgct cgctgcaacc tccacctcct gggttccagc gattctcctg cctcagccc 181 ccgagggggt agctgggact acaggtgcgc accaccatgc ccagccaatt ttgtattttt 241 cgtagagatg gggtttcacc atgttgtcca ggctggtctt gaactcctga cctcaggtga 301 tcctcccgcc tcggcctccc aaagtgctgg aattacaggc gtgatccacc gcacccggcc 361 tattttttga gagagggcca cacctgtcg tcccggctgg aatgcagtga tgcgatcacc WO 00/09525 PCT/US99/17712 EPI-109 899 421 gcccactaca gcctcgacct ccgggctcaa gcaatcctcc ccgcccaacc tcctgagtag 481 cgagcgcctc gacgcccagc taatttttat ttttatttat ttttttgtag agacggcgtc 541 tctctaagat gcccaggctg gtggccggtg tcgaactcct aagatgaagc gatcctcccc 601 ggccttggcc tccgcgcctc ctaaagcgcc aggtatgagc caccgcgcct ggcctacaag 661 tgcattttaa ttaaagtatt attaatgtct ttgcctgaag aaattcgctt ttaaattgtg 721 acttatcttt cacccaaaaa tcaaagcaca attcagcccc gaggcggggg cggtaggagc 781 tgggcggggc gggggcaggg aaagaccagg agcagagatt caaaaagagt aagagggcaa 841 aatgtgcata atgcatcttc acaggtaaga gcctggccag gctcctattt taatggcttc 901 ctcctgaaga agattcaagc agagtgtaag atattttcgg aaagtagagc attttgaaag 961 catttcataa tctctcaaaa ccggagactg ctcctgtccc acctcgttag agaaaacagc 1021 gatgctcaaa ggcaacctcc ttcctgacat tgcctggtag gacgcgacgt ggtgtttgcc 1081 cgcgcggaat gcggacgcaa ggctgctcct aggtctcggg gacgcgccat ccccatttcc 1141 gctcgcggag gcgtagggtc cgggcgcggg accccagtcg accttgactg gcggcgcgac 1201 cttgaggcct gcgttcgcct cagttgcccc ctctgtgcaa tggggagacg cgcctcatcg 1261 cttgacaacg gccgaagagc cgccgcgctt ccgtctcccg cgtgcgcgcg ccatgctgcc 1321 cacccccgtt ccgcactgac cctcccccgt gccccgcgtc ccgtactgcc gccccgcccc 1381 gagtcccatg ccgcagccac cgcgacggag cccgcaggcg ggaacctgcc tccgcgcgtt 1441 agcgcgcacg cgcgcctcat gtgtcgtccc catcagcgcc ggcttccgtc tataggccag 1501 atgcactgtc actctggcga agtcgcagac ccgattggcc gggacggagg cgcgagaccg 1561 ggttgcgggc ggggccgaac gtggtataaa acgggcggga ggccaggctc gtgccgtttt 1621 gcagacgcca ccgccgagga aaaccgtgta ctattagcca tggtcaaccc caccgtgttc 1681 ttcgacattg ccgtcgacgg cgagcccttg ggccgcgtct cctttgaggt cgggcgggcg 1741 gcggcgtgcg ggaatggggc ccagaaagtg ggccggggtc ggggtgggtg gtagcgcccc 1801 aaaggcccgg gcgcggggcg accctgcttg aggggcgagc gcgggcgggc tgcggcgcca 1861 tttcctgacg aggggccatt ttgggaggtc cgcgagtcgc gggaggaggc cgggacgcgg 1921 cggacaaagg caggcggggc ggctgcgagg ccgttggggg agggggcccg cgtccgcccg 1981 cccgcctcat gtggccgcgc cctgtcctgt ccgacgcacg tgctcggcgg ccgcgctcag 2041 gtccgcgcct tgagagtcgt tgtccgccct agcttggcct gggcgccgca gaccggagcc 2101 agaagcacgc tcgcgggggc ttgcgaccgc cttcctggga agctgtcccc tggcaggcat 2161 gggtgcttta catcctgagc tgggaagctg tttgcttgag ggtttttctc aaggatcgag 2221 gcgcggtgtg agcccgtcca tgctcggtcc tgtagatccc gggaggccat gttataaaag 2281 gagacttgct gggatgtgac gggttgccac ttgaaatatc ttccatttgg ataaagtagg 2341 aatatttata catgtgcccc aaacgtccct ccgtgtcccc cacccccaag cggaaatgtg 2401 aaaatgggcc ttgcctttgc tggtgcccaa ggaccgcctt ccactgcagt gacggcgctg 2461 gcgggggagg cgctcttgag cccctcccga ttgtccctct gcctagcaag caagttgcga 2521 ctggccacaa ggcaggcctc ttccgaccaa ggtggattac cagtgattac ctaattagtt 2581 ttgagagcgt taaatgagtt cttaaagatc agttgtaatt atagcatagt atctaaactt 2641 ggcgcgtgtc ttcaaagtta aatattgagt acgattccgt tccagttaac atggatagac 2701 cttagggagt agcgaaatag gatgttagtg gttttattcc tttaaatcac atctcaaaag 2761 gccaccaatg gctagtttgg atcttattcc gaaaatagat tgatcctcat gcagtcttcg 2821 tgaggacaga gcgatttcct tgttgcctac cctgtccata gtgcctggca cataggcact 2881 gaaacactgc atgttaatcc acaccccacc ccacctatga gtgtagtcaa agctggtaag 2941 tgacaagggc tttcgtggaa acttggcctg acctaatgtt gggcatcagg ttacccaaag 3001 agcttcaggg aaatgagaaa ggacttgcag gtcttgatga gaatggaggg gtaactgcca 3061 atgagggctt tggctttagc gaaagtctga aagggaagcc ataggaactt aaacgtaccg 3121 actataaagc tctgagaaaa gctgatgttt tagaaagacc atacattcta ggtacaaata 3181 cctaaaaact aaaaaataag tacgttggcc aggcgggcgg atcacgaagt caggagattg 3241 agaccatcct gggcccctgg tgaaacccca cctctattaa aaatacaaaa attagctggg 3301 cgtggtggcg cttgcctgta atctcagcta ctctagaggc tgaggcagga gatcgcttga 3361 accccggagg cggaggctgc agtgagccga gatcgtgcca ctgcactcca gcctggtgac 3421 agcgagactc ttgtctcaaa aaaaaaaaag tacattgcta taagagaagt gcacacggat 3481 actagtagtt aattcagtca catctgtgaa atagcttata aaatgctact tttaaacaag 3541 ctgtttttat gaaagggctt gtaaatgttt atggtattta agctacctct ctagccataa 3601 cgtattatac attcaagaaa ggttcaaaac cagatatact agaaaccaat ctttattttt 3661 taccccacta ctaggtaagg gcctggatac caagaagtga ctgctcatct aatccataaa 3721 gctatgttaa cagattggag gtagtagcat tttcattaca agtgactaaa agaacagctg 3781 tttacccctg atcgtgcagc agtgcttgct gttccttaga attttgcctt gtaagttcta 3841 gctcaagttg gggggtggtg atagacattt aagaagccat atatcttttc agaagtaggt 3901 gtgatgtact aaaagtttga gacactttct agaagtctca ctatttaagt tatgactagt 3961 attggatttt tggcatgtct ttgggtttca tgtttcttaa cccaactgcc tgcagggcct 4021 tatggctgtc aggagcagtt cttgggaatt aaagtaatta ctgaagaagt attctagtga 4081 gaaaatgaat ttatgactca gaagccccta aagacatggg tactaagcaa caaaataagc 4141 agatgttaat taactgtaat tttctcttac agctgtttgc agacaaggtc ccaaagacag 4201 caggttggtc cattttctaa gtttaacaaa gatgttccaa ttgtgacagt ttgtgtgtgt 4261 gtgtgtatat atatattttt atgtatgtat atatgtgttt aatttttttt taaacagaaa 4321 attttcgtgc tctgagcact ggagagaaag gatttggtta taagggttcc tgctttcaca 4381 gaattattcc agggtttatg tgtcaggtac gaaatttact gaattttatt ttatttgggt 4441 tgctcccttc atttgggatt gagccagaat atttcaggat acacatatct gaactgttac WO 00/09525 PCT/US99/17712 EPI-109 900 4501 tctaccattt cggttctatt taacccttct attcagtttg aacttgggtt taaagtttga 4561 accttgcaga tttggcacac ttcatggtta tgttgtcaga agtgacattt ttcctatatg 4621 ttgacagggt ggtgacttca cacgccataa tggcactggt ggcaagtcca tctatgggga 4681 gaaatttgaa gatgagaact tcatcctaaa gcatacgggt cctggcatct tgtccatggc 4741 aaatgctgga cccaacacaa atggttccca gtttttcatc tgcactgcca agactgagtg 4801 gtaagggtac aacatggcac actaaccacc tgactaaatg aaaagttgcc ctggggggaa 4861 cggaacaaac actacttttc ttcaaccttt gcttccacag actttttcat ccctaagata 4921 ctagaagaag agcatacata aatgacaaat atagccaatg tgatacagaa tgtcagatac 4981 tatgatagaa acttggccct tagctgggtg gttgaattag gtgctacttt tttgagatgg 5041 agttttgctc tgttgccagg ttggagtgca gtggcacaat ctgggctcac tgcaacctct 5101 gcctcctggg ttcaagcga't tctcctgcct tggcctcctg agtagctgag aatacagatg 5161 tgtgccagca tgcctggcta attttttgta tttttgtgga gacggggttt catcatgttg 5221 gccaagctgg tcttgaactc gtgacttaag gtgaaccacc tgccttggcc ccccaaagtg 5281 ctgggatttc aggcatgagc cactgcgccc aaccaattaa gtgctttttt tttttttttt 5341 cttttctcag actggatctc gctcttatct cccaggttgg agtgcagtgg tgccatctca 5401 gctcactgca acctcctccc gggttcaagc aattcttctg cctcagcctc tcaagtagct 5461 ggaactacag gcatgcacca ccactcccag ctaaattgtg tattattagt agagcgggat 5521 ttaccatgtt gtccaggctg gtctcgaact cctgggctca agtgatctgc ctgccttgac 5581 ccccccgaag tgctgggatt acaggcatga gccactgtgc ccacccaatt aagtgctgct 5641 tttatgttac tattaataac atgcggttgg ttgggttttt tgtttctttg gggtttttgt 5701 tttgttttgt ttgtttttgg gggagggggg cgcaattcat tctatatgtg taactctttt 5761 ttgagatgga gtttcgctct gtcgcccagg ctggagtgca gtggcgcgat ctcggctcac 5821 tgcaagctcc gcctcccagg ttcacgccat tctcctgcct cagcctcccg agtagctggg 5881 actataggca catgccacca tgcccggcta attttttgta tttttagtag agacagggtt 5941 tcaccgtgtt agccaggatg gtctcgatct cctgacctcg tgatccgccc gccttggcct 6001 cccaaagtgc tgggattaca ggcgtgagcc accgcacccg gcctatatgt gtaactcttt 6061 aatggtaatt ggagaatcat gtttaatgac atttagtaca aaaggcttca gttaaaaaaa 6121 aaaaaaaaaa gctacctttc tcgtcttggt tcatgacaca tggaggctgc ttgtttgtgg 6181 ttgccagtca taatgattgt tcttcctttt caaggttgga tggcaagcat gtggtgtttg 6241 gcaaagtgaa agaaggcatg aatattgtgg aggccatgga gcgctttggg tccaggaatg 6301 gcaagaccag caagaagatc accattgctg actgtggaca actcgaataa gtttgacttg 6361 tgttttatct taaccaccag atcattcctt ctgtagctca ggagagcacc cctccacccc 6421 atttgctcgc agtatcctag aatctttgtg ctctcgctgc agttcccttt gggttccatg 6481 ttttccttgt tccctcccat gcctagctgg attgcagagt taagtttatg attatgaaat 6541 aaaaactaaa taacaattgt cctcgtttga gttaagtgtt gatgtaggct ttattttaag 6601 cagtaatggg ttacttctga aacatcactt gtttgcttaa ttctacacag tacttagatt 6661 ttttttactt tccagtccca ggaagtgtca atgtttgttg agtggaatat t (2) INFORMATION FOR SEQ ID NO:2690: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2690 1 gtgtactatt agccatggtc aaccccaccg tgttcttcga cattgccgtc gacggcgagc 61 ccttgggccg cgtctccttt gagctgtttg cagacaaggt cccaaagaca gcagaaaatt 121 ttcgtgctct gagcactgga gagaaaggat ttggttataa gggttcctgc tttcacagaa 181 ttattccagg gtttatgtgt cagggtggtg acttcacacg ccataatggc actggtggca 241 agtccatcta tggggagaaa tttgaagatg agaacttcat cctaaagcat acgggtcctg 301 gcatcttgtc catggcaaat gctggaccca acacaaatgg ttcccagttt ttcatctgca 361 ctgccaagac tgagtggttg gatggcaagc atgtggtgtt tggcaaagtg aaagaaggca 421 tgaatattgt ggaggccatg gagcgctttg ggtccaggaa tggcaagacc agcaagaaga 481 tcaccattgc tgactgtgga caactcgaat aagtttgact tgtgttttat cttaaccacc 541 agatcattcc ttctgtagct caggagagca cccctccacc ccatttgctc gcagtatcct 601 agaatctttg tgctctcgct gcagttccct ttgggttcca tgttttcctt gttccctccc 661 atgcctagct ggattgcaga gttaagttta tgattatgaa ataaaaacta aataacaatt 721 gtc (2) INFORMATION FOR SEQ ID NO:2691: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2691 1 gaattccgga gttccgggcg cgcgcgacgt cagtttgagt tctgtgttct ccccgcccgt 61 gtcccgcccg acccgcgccc gcgatgctgg cgctgcgctg cggctcccgc tggctcggcc 121 tgctctccgt cccgcgctcc gtgccgctgc gcctccccgc ggcccgcgcc tgcagcaagg WO 00/09525 PCT/US99/17712 EPI-109 901 181 gctccggcga cccgtcctct tcctcctcct ccgggaaccc gctcgtgtac ctggacgtgg 241 acgccaacgg gaagccgctc ggccgcgtgg tgctggagct gaaggcagat gtcgtcccaa 301 agacagctga gaacttcaga gccctgtgca ctggtgagaa gggcttcggc tacaaaggct 361 ccaccttcca cagggtgatc ccttccttca tgtgccaggc gggcgacttc accaaccaca 421 atggcacagg cgggaagtcc atctacggaa gccgctttcc tgacgagaac tttacactga 481 agcacgtggg gccaggtgtc ctgtccatgg ctaatgctgg tcctaacacc aacggctccc 541 agttcttcat ctgcaccata aagacagact ggttggatgg caagcatgtt gtgttcggtc 601 acgtcaaaga gggcatggac gtcgtgaaga aaatagaatc tctcggctct aagagtggga 661 ggacatccaa gaagattgtc atcacagact gtggccagtt gagctaatct gtggccaggg 721 tgctggcatg gtggcagctg caaatgtcca tgcacccagg tggccgcgtt gggctgtcag 781 ccaaggtgcc tgaaacgata cgtgtgccca ctccactgtc acagtgtgcc tgaggaaggc 841 tgctagggat gttagacgga attcc 1 ttttgcagac gccaccgccg aggaaaaccg tgtactatta gccatggtc 1 cgggaacgca acatgaaggt gctccttgcc gccgccctca tcgcggggtc cgtcttcttc 61 ctgctgctgc cgggaccttc tgcggccgat gagaagaaga aggggcccaa agtcaccgtc 121 aaggtgtatt ttgacctacg aattggaqat gaagatgtag gccgggtgat ctttggtctc 181 ttcggaaaca ctgttccaaa aacagtggat aattttgtgg ccttagctac aggagagaaa 241 ggatttggct acaaaaacag caaattccat cgtgtaatca aggacttcat gatccagggc 301 ggagacttca ccaggggaga tggcacagga ggaaagagca tctacggtga gcgcttcccc 361 gatgagaact tcaaactgaa gcactacggg cctggctggg tcagcatggc caacgcaggc 421 aaagacacca acggctccca gttcttcatc acgacagtca agacagcctg gctagatggc 481 aagcatgtgg tgtttggcaa aqttctagag ggcatggagg tggtgcggaa ggtggagagc 541 accaagacag acagccggga taaaccccig aaggatgtga tcatcgcaga ctgcggcaag 601 atcgaggtgg agaagccctt tgccatcgcc aaggagtagg gcacagggac atctttcttt 661 gagtgaccgt ctgtgcaggc cctgtagtcc gccacagggc tctgagctgc actggccccg 721 gtgctggcat ctggtggagc ggacccactc ccctcacatt ccacaggccc atggactcac 781 ttttgtaaca aactcctacc aacactgacc aataaaaaaa aatgtgggtt tttttttttt 841 ttaataaaaa a 1 gaaggtgctc cttgccgccg ccctcatcgc ggggtccgtc ttcttcctgc tgctgccggg 61 accttctgcg gccgatgaga agaagaaggg gcccaaagtc accgtcaagg tgtattttga 121 cctacgaatt ggagatgaag atgtaggccg ggtgatcttt ggtctctttg gaaagactgt 181 tccaaaaaca gtggataatt ttgtggcctt agctacagga gagaaaggat ttggctacaa 241 aaacagcaaa ttccatcgtg taatcaagga cttcatgatc cagggcggag acttcaccag 301 gggagatggc acaggaggaa agagcatcta cggtgagcgc ttccccgatg agaacttcaa 361 actgaagcac tacgggcctg gctgggtgag catggccaac gcaggcaaag acaccaacgg 421 ctcccagttc ttcatcacga cagtcaagac agcctggcta gatggcaagc atgtggtgtt 481 tggcaaagtt ctagagggca tggaggtggt gcggaaggtg gagagtacca agacagacag 541 ccgggataaa cccctgaagg atgtgatcat cgcagactgc ggcaagatcg aggtggagaa 601 gccctttgcc atcgccaagg agtagggcac agggacatct ttctttgagt gaccgtctgt 661 gcaggccctg tagtccgcca cagggctctg agctgcactg gccccggtgc tggcatctgg 721 tggagcggac ccactcccct cacattccac aggcccatgg actcactttt gtaacaaact 781 cctaccaaca ctgaccaata aaaaaaaatg tgggtttttt tttttaataa aag 1 gaattccctt gtaaggtttt cttaacaaaa caccagtcac ataagtgcat tttattttat 61 atttttgttt atttatttga gacggagtct cttgtctctc aggctggagt gcagtggcgc 121 catctctgct cgctgcaacc tccacctcct gggttccagc gattctcctg cctcagcctc 181 ccgagggggt agctgggact acaggtgcgc accaccatgc ccagctaatt ttgtattttt 241 cgtagagatg gggtttcacc atgttgtcca ggctggtctt gaactcctga cctcaggtga 301 tcctcccgcc tcggcctccc aaagtgctgg aattacaggc gtgatccacc gcacccggcc 361 tattttttga gagagggtca cactctgtcg tcccggctgg aatgcagtga tgcgatcacc 421 gcccactaca gcctcgacct ccgggctcaa gcaatcctcc ccgcccagcc tcctgagtag 481 cgagcgcctc gacgcccagc taatttttat ttttatttat ttttttgtag agacggcgtc 541 tctctaagat gcccaggctg gtggccggtg tcgaactcct aagatgaagc gatcctcccc 601 ggccttggcc tccgcgcctc ctaaagcgcc aggtatgagc caccgcgcct ggcctacaag 661 tgcattttaa ttaaagtatt attaatgtct ttgcctgaag aaattcgctt ttaaattgtg 721 acttatcttt cacccaaaaa tcaaagcaca attcagcccc gaggcggggg cggtaggagc 781 tgggcggggc gggggcaggg aaagaccagg agcagagatt caaaaagagt aagagggcaa 841 aatgtgcata atgcatcttc acaggtaaga gcctggccag gctcctgttt taatggcttc 901 ctcctgaaga agattcaagc agagtgtaag atattttcgg aaagtagagc attttgaaag 961. catttcataa tctctcaaaa ccggagacg ctcctgtccc acctcgttag agaaaacagc 1021 gatgctcaaa ggcaacctcc ttcctgacat tgcctggtag gacgcgacgt ggctgtttgcc 1081 cgcgcggaat gcggacgcaa ggctgctcct aggtctcggg gacgcgccat ccccatttcc 1141 gctcgcggag gcgtagggtc cgggcgcggg accccagtcg accttgactg gcggcgcgac 1201 cttgaggcct gcgttcgcct cagttgcccc ctctgtgcaa tggggagacg cgcctcatcg 1261 cttgacaacg gccgaagagc cgccgcgctt ccgtctcccg cgtgcgcgcg ccatgctgcc 1321 cacccccgtt ccgcactgac cctcccccgt gccccgcgtc ccgtactgcc gccccgcccc 1381 gagtcccatg ccgcagccac cgcgacggag cccgcaggcg ggaacctgcc tccgcgcgtt 1441 agcgcgcacg cgcgcctcat gtgtcgtccc catcagcgcc ggcttccgtc tataggccag 1501 atgcactgtc actctggcga agtcgcagac ccgattggcc gggacggagg cgcgagaccg WO 00/09525 PCT/US99/17712 EPI-109 902 1561 ggttgcgggc ggggccgaac gtggtataaa acgggcggga ggccaggctc gtgccgtttt 1621 gcagacgcca ccgccgagga aaaccgtgta ctattagcca tggtcaaccc caccgtgttc 1681 ttcgacattg ccgtcgacgg cgagcccttg ggccgcgtct cctttgaggt cgggcgggcg. 1741 gcggcgtgcg ggaatggggc ccagaaagtg ggccggggtc ggggtgggtg gtagcgcccc 1801 aaaggcccgg gcgcggggcg accctgcttg aggggcgagc gcgggcgggc tgcggcgcca 1861 tttcctgacg aggggccart ttgggaggtc cgcgagtcgc gggaggaggc cgggacgcgg 1921 cggacaaagg caggcggggc ggctgcgagg ccgttggggg agggggcccg cgtccgcccg 1981 cccgcctcat gtggccgcgc cctgtcctgt ccgacgcacg tgctcggcgg ccgcgctcag 2041 gtccgcgcct tgagagtcat tgtccgccct agcttggcct gggcgccgca gaccggagcc 2101 agaagcacgc tcgcgggggc ttgcgaccgc cttcctggga agctgtcccc tggcaggcat 2161 gggtgcttta catcctgagc tgggaagctg tttgcttgag ggtttttctc aaggatcgag 2221 gcgcggtgtg agcccgtcca tgctcggtcc tgtagatccc gggaggccat gttataaaag 2281 gagacttgct gggatgtgac gggttgccac ttgaaatatc ttccatttgg ataaagtagg 2341 aatatttata catgtgcccc aaacgtccct ccgtgtcccc cacccccaag cggaaatgtg 2401 aaaatgggcc ttgcctttgc tggtgcccaa ggaccgcctt ccactgcagt gacggcgctg 2461 gcgggggagg cgctcttgag cccctcccga ttgtccctct gcctagcaag caagttgcga 2521 ctggccacaa ggcaggcctc ttccgaccaa ggtggattac cagtgattac ctaattagtt 2581 ttgagagcgt taaatgagtt cttaaagatc agttgtaatt atagcatagt atctaaactt 2641 ggcgcgtgtc ttcaaagtta aatattgagt acgattccgt tccagttaac atggatagac 2701 cttagggagt agcgaaatag gatgttagtg gttttattcc tttaaatcac atctcaaaag 2761 gccaccaatg gctagtttgg atcttattcc gaaaatagat tgatcctcat gcagtcttcg 2821 tgaggacaga gcgatttcct tgttgcctac cctgtccata gtgcctggca cataggcact 2881 gaaacactgc atgttaatcc acaccccacc ccacctatga gtgtagtcaa agctggtaag 2941 tgacaagggc tttcgtggaa acttggcctg acctaatgtt gggcatcagg ttacccaaag 3001 agcttcaggg aaatgagaaa ggacttgcag gtcttgatga gaatggaggg gtaactgcca 3061 atgagggctt tggctttagc gaaagtctga aagggaagcc ataggaactt aaacgtaccg 3121 actataaagc tctgagaaaa gctgatgttt tagaaagacc atacattcta ggtacaaata 3181 cctaaaaact aaaaaataag tacgttggcc aggcgggcgg atcacgaagt caggagattg 3241 agaccatcct gggcccctgg tgaaacccca cctctattaa aaatacaaaa attagctggg 3301 cgtggtggcg cttgcctgta atctcagcta ctctagaggc tgaggcagga gatcgcttga 3361 accccggagg cggaggctgc agtgagccga gatcgtgcca ctgcactcca gcctggtgac 3421 agcgagactc ttgtctcaaa aaaaaaaaag tacattgcta taagagaagt gcacacggat 3481 actagtagtt aattcagtca catctgtgaa atagcttata aaatgctact tttaaacaag 3541 ctgtttttat gaaagggctt gtaaatgttt atggtattta agctacctct ctagccataa 3601 cgtattatac attcaagaaa ggttcaaaac cagatatact agaaaccaat ctttattttt 3661 taccccacta ctaggtaagg gcctggatac caagaagtga ctgctcatct aatccataaa 3721 gctatgttaa cagattggag gtagtagcat tttcattaca agtgactaaa agaacagctg 3781 tttacccctg atcgtgcagc agtgcttgct gttccttaga attttgcctt gtaagttcta 3841 gctcaagttg gggggtggtg atagacattt aagaagccat atatcttttc agaagtaggt 3901 gtgatgtact aaaagtttga gacactttct agaagtctca ctatttaagt tatgactagt 3961 attggatttt tggcatgtct ttgggtttca tgtttcttaa cccaactgcc tgcagggcct 4021 tatggctgtc aggagcagtt cttgggaatt aaagtaatta ctgaagaagt attctagtga 4081 gaaaatgaat ttatgactca gaagccccta aagacatggg tactaagcaa caaaataagc 4141 agatgttaat taactgtaat tttctcttac agctgtttgc agacaaggtc ccaaagacag 4201 caggttggtc cattttctaa gtttaacaaa gatgttccaa ttgtgacagt ttgtgtgtgt 4261 gtgtgtatat atatattttt atgtatgtat atatgtgttt aatttttttt taaacagaaa 4321 attttcgtgc tctgagcact ggagagaaag gatttggtta taagggttcc tgctttcaca 4381 gaattattcc agggtttatg tgtcaggtac gaaatttact gaattttatt ttatttgggt 4441 tgctcccttc atttgggatt gagccagaat atttcaggat acacatatct gaactgttac 4501 tctaccattt cggttctatt taacccttct attcagtttg aacttgggtt taaagtttga 4561 accttgcaga tttggcacac ttcatggtta tgttgtcaga agtgacattt ttcctatatg 4621 ttgacagggt ggtgacttca cacgccataa tggcactggt ggcaagtcca tctatgggga 4681 gaaatttgaa gatgagaact tcatcctaaa gcatacgggt cctggcatct tgtccatggc 4741 aaatgctgga cccaacacaa atggttccca gtttttcatc tgcactgcca agactgagtg 4801 gtaagggtac aacatggcac actaaccacc tgactaaatg aaaagttgcc ctggggggaa 4861 cggaacaaac actacttttc ttcaaccttt gcttccacag actttttcat ccctaagata 4921 ctagaagaag agcatacata aatgacaaat atagccaatg tgatacagaa tgtcagatac 4981 tatgatagaa acttggccct tagctgggtg gttgaattag gtgctacttt tttgagatgg 5041. agttttgctc tgttgccagg ttggagtgca gtggcacaat ctgggctcac tgcaacctct 5101 gcctcctggg ttcaagcgat tctcctgcct tggcctcctg agtagctgag aatacagatg 5161 tgtgccagca tgcctggcta attttttgta tttttgtgga gacggggttt catcatgttg 5221 gccaagctgg tcttgaactc gtgacttaag gtgaaccacc tgccttggcc ccccaaagtg 5281 ctgggatttc aggcatgagc cactgcgccc aaccaattaa gtgctttttt tttttttttt 5341 cttttctcag actggatctc gctcttatct cccaggttgg agtgcagtgg tgccatctca 5401 gctcactgca acctcctccc gggttcaagc aattcttctg cctcagcctc tcaagtagct 5461 ggaactacag gcatgcacca ccactcccag ctaaattgtg tattattagt agagcgggat 5521 ttaccatgtt gtccaggctg gtctcgaact cctgggctca agtgatctgc ctgccttgac 5581 ccccccgaag tgctgggatt acaggcatga gccactgtgc ccacccaatt aagtgctgct WO 00/09525 PCT/US99/17712 EPI-109 903 5641 tttatgttac tattaataac atgcggttgg ttgggttttt tgtttczttg gggtttttgt 5701 tttgttttgt ttgtttttgg gggagggggg cgcaattcat tctatatgtg taactctttt 5761 ttgagatgga gtttcgctct gtcgcccagg ctggagtgca gtggcgcgat ctcggctcac 5821 tgcaagctcc gcctcccagg ttcacgccat tctcctgcct cagcctcccg agtagctggg 5881 actataggca catgccacca tgcccggcta attttttgta tttttagtag agacagggtt 5941 tcaccgtgtt agccaggatg gtctcgatct cctgacctcg tgatccgccc gccttggcct 6001 cccaaagtgc tgggattaca ggcgtgagcc accgcacccg gcctatatgt gtaactcttt 6061 aatggtaatt ggagaatcat gtttaatgac atttagtaca aaaggcttca gttaaaaaaa 6121 aaaaaaaaaa gctacctttc tcgtcttggt tcatgacaca tggaggctgc ttgtttgtgg 6181 ttgccagtca taatgattgt tcttcctttt caaggttgga tggcaagcat gtggtgtttg 6241 gcaaagtgaa agaaggcatg aatattgtgg aggccatgga gcgctttggg tccaggaatg 6301 gcaagaccag caagaagatc accattgctg actgtggaca actcgaataa gtttgacttg 6361 tgttttatct taaccaccag atcattcctt ctgtagctca ggagagcacc cctccacccc 6421 atttgctcgc agtatcctag aatctttgtg ctctcgctgc agttcccttt gggttccatg 6481 ttttccttgt tccctcccat gcctagctgg attgcagagt taagtttatg attatgaaat 6541 aaaaactaaa taacaattgt cctcgtttga gttaagtgtt gatgtaggct ttattttaag 6601 cagtaatggg ttacttctga aacatcactt gtttgcttaa ttctacacag tacttagatt 6661 ttttttactt tccagtccca ggaagtgtca atgtttgttg agtggaatat t 1 gtgtactatt agccatggtc aaccccaccg tgttcttcga cattgccgtc gacggcgagc 61 ccttgggccg cgtctccttt gagctgtttg cagacaaggt cccaaagaca gcagaaaatt 121 ttcgtgctct gagcactgga gagaaaggat ttggttataa gggttcctgc tttcacagaa 181 ttattccagg gtttatqtgt cagggtggtg acttcacacg ccataatggc actggtggca 241 agtccatcta tggggagaaa tttgaagatg agaacttcat cctaaaqcat acgggtcctg 301 gcatcttgtc catggcaaat gctggaccca acacaaatgg ttcccagttt ttcatctgca 361 ctgccaagac tgagtggttg gatggcaagc atgtggtgtt tggcaaagtg aaagaaggca 421 tgaatattgt ggaggccatg gagcgctttg ggtccaggaa tggcaagacc agcaagaaga 481 tcaccattgc tgactgtgga caactcgaat aagtttgact tgtgttttat cttaaccacc 541 agatcattcc ttctgtagct caggagagca cccctccacc ccatttgctc gcagtatcct 601 agaatctttg tgctctcgct gcagttccct ttgggttcca tgttttcctt gttccctccc 661 atgcctagct ggattgcaga gttaagttta tgattatgaa ataaaaacta aataacaatt 721 gtc (2) INFORMATION FOR SEQ ID NO:2692: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: _base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2692 1 gatctgtcta gggctgtcag tggagtattg aagtccccca cgattattgt gttactgtct 61 atctcatttc ttaggtctat taataacagg tttttttgtt ttgttttgtt ttgttttgtt 121 tttttgagat ggagttttgc tcttgttgcc caggctggag tgcaatggca tgatctcagc 181 tcactgcaac ctccgcctcc tgggttcaag cgattctcct gcctcagcct cccgagcagc 241 tgggactaca ggcatgcacc accacacctg gctaattttg tatttttagt agagacaagg 301 gttctccatg ttggtcaggc tggtcttgaa ctcccgacct ctggtgatct tcccacctca 361 gcctcccaaa gcgctgggat tacaggcatg agccaccgtg cccggcccat agtaactgtt 421 ttataaattt gggagctcca gtgtttagta catatatgtt tagaattgtg atatttccct 481 gttggacaag gccttttacc attatataat gccctctttt gtctctttta gctgctgttg 541 ctttaaaatt tgttttgtct gatataagaa tagctacctc tgctcacttt tggtgtctat 601 gtgcatgaaa tgcctttctc caccccttta ctttatgtga gtccttatgt gttgttaggc 661 cagcatcacc ctaatatcaa aaccagcaaa ggacatacca aaaaagaaca ttacagacca 721 atatttttga tgaacacaga tgctaaaatc ctcaacaaaa tactagctaa ccagttgcaa 781 caacatacca aaaagataat ccaccatgat caagtaagtt tcgtaccagg gatgcagaaa 841 agcagcagat ggtttgtgag ttcttatcta ttctgcaatt ctgtagaaaa gtggagcatt 901 taggccattt acattcaatg ttagtattga aatttgaggt accattgcat tcatcatgct 961 ctttgttgcc tgcgtacttt ggtttgtttt ttgattttgc tctttaactt gtatttttgt 1021 tttataggtc ctgtgtgatt tatgctttaa agagattctg ttttgatgtg tttccaggat 1081 ttctttcaag atttagagct cctttaaaca gttcttgtag cagtgccttg gtaatggcaa 1141 attctctcag tatttgtttg tctgaaaacg actgtatctt tccttcatat gtgatgctta 1201 gtttcactgg atgcaaaatt cttgactgat aattgttttg tttgaggagg ctgaagatag 1261 ggccccaacc ccttctagct tgtagggtct ctgctgagaa atctgctatt aatctgatag 1321 gttttcctta taggttacct ggtgcttctg tctcacagct cttaagattc tttccttggt 1381 cttaactttg tataacctga cgacaatgtg cctaggtgaa tatctttttg tatccatcgc 1441 ccaggctgga gtgcagtggc gcaattttgg ctcactgcaa cctctgcctc ccaggttcaa 1501 gcaattctcc tgcctcagcc tcccaaggag ctgggattac aggctcctgc caccacaccc 1561 agctaatttt ttttttttgt atttttagta gagacagggt tttgccatgt tggccagcct 1621 ggtctcaaac tcctgacctc aggtgatcca cctgcctcgg cctcccaaag tgctaggatt 1681 acaggcgtga gcccccgcac ccgagccctg atattaattt ttaaattaaa agactttatt 1741 tttaaaagca gtttgaggtt tacagaaaaa ctgagcagaa agtacagtct ctatataccc 1801 cctactccct gcccccagtt ttccctgtta ttaacatttg tgttaatgtg gcatatttgt 1861 tacaatcagt gaatcaatat tgataaatta aagtccatat gttagtgttc actctgtgtg 1921 ttatacagtt ctatgggttt tgccaaatgt attaatatgt catgtatcca tcattacagt WO 00/09525 PCT/US99/17712 EPI-109 904 1981 atcatccagc ataatttcac tgtcctgaaa atgccctgtg ctccacttat tcatcttttc 2041 cccacttgct atcaccacac caaagccctc acaaccactt atctttttaa tatatccata 2101 gttttgcctt ttgcagaaca tcatatcatt agaatcacaa taatatgtgg cttttcagac 2161 tggtttcttt cactcagcaa catgcagtta agggtcttcc gggtcttttg tggcttgaca 2221 gctcatttct ttttatcact gaataatatt gcattgtata gatataccac agtttttttt 2281 aaatttactc atcattaaag gacatcttga ttacttctaa tttctggcaa taatgaataa 2341 agttgataca aaaacttttg tgtaggattt tgtgtggaca tatgttttca actcattgag 2401 gtaaatgcct aaggcatatt tagttttgta agaaactgct aaactatctt ccaaagtatc 2461 tgtaccattt tgcattccca ccagctatga aagagtttct gttctacatc ttcacaaaca 2521 ttggtgttat cagtgttttg gattttagcc attctaattg gtgtggagtg gtatctcatt 2581 gttgttttaa ttttgcaatt ccctaatgac atatatgttg agcatctttt catatgcata 2641 tttaccatct gtatatcttc tttgggcata tgtccattca gatcttttgc acatcttttc 2701 attgggttgc tcattttctt attgagtttt aagagttctt catatatttt tgataacagt 2761 cctttatcag atatgtcttc tgcaaatatt ttctcccagt ctttgtcgtg tcttttcatt 2821 tacttaacag tgtctttcat aaaacagaag gttttaactt tgatgaagtc taacttgcca 2881 attttttctt tcatggattg tgctttgtgt gttgtatcta aaaactcatt gccaaacaca 2941 aggtcacctc tatgttctcc tatgttatct tctagaagct ttgtagtttt ctgttttaca 3001 tttatagggg ctgtgagaag gtgacagagg ttacatgagg taataaggat agggccttag 3061 ttgaataagg ctagtgccct tataagagga agagacgcca gttttctctc tctctaccat 3121 acgaagacac agcaagaaag tggccatcta caagtcaaga agtgggccat caccagaaac 3181 caaattactg gcaccttgat cttaaacttc ccagcttcca aaactgtgag aaataaattt 3241 ctgctgttta agccatgcaa cctacagtat aagttatagc agcccaagca gactaagaca 3301 gaacccttag catattaatc atagttactt taaatctctg gtcccataat tccaaaatat 3361 ctgccacatc tgagtctggt tctagtgctt gctttgtttc ttcaagactg tggttttttt 3421 tctcttttta gcatatctta taatttttct gttcaaagca aggcatgatg tactgggtaa 3481 agggaactga actgaggtag ataggtgttt agaatgaaat ttagaggcaa cttaagaaag 3541 tactcaaaaa acaaaattat gggagcatgc taaatggaca caggagccag cctgaaagag 3601 cttgcaatgg acaaagttgg aacaatttga gcaacaaaat aagttattct tccttataga 3661 ggaattctaa ataatttata tagatacttg ccttccagga agtggcactt aatccccatc 3721 aaaccctcat aagtgtgggc tggacttggt aacttccttc caaaaaatag agtatggaaa 3781 aggggtgaag taacttcata gtggaaaaac ctggcaaaca ctaccttggt tagctgagca 3841 aagccttgat atggtgtgat gagaatggaa tattaccttt gtgatctttc tctcaaacac 3901 ttataatccc attctaatca tgaggaaagc gtaagacaaa tcccaattga gggacattct 3961 acaaaatacc tgaggagtac tcctcaatag gtcatcaaaa caagtcttag aaactgtcac 4021 agtcaagaag aaactaagga aaaatgacaa ctaaatgcaa tgtggtatca tggactggct 4081 cctagaacag aaaaagtcag tatataaaaa ctaagaaaat ctgaataaag tatggacttt 4141 agtgataata atgtatcaat attggtttat tacttgtagc aaatgtacca tactaatcta 4201 agatgataat aaaaacaata actctgtgta gggccaaagg gagggaagtg ggctgatacg 4261 ggaactctcc gcactatctt agcaactttt tggcaaatct aaaattactc caagatacta 4321 agcttctttt ttaaaaaaaa tcacaaaacc tgaaaaattt taaagaaata aaaatttaaa 4381 aattaaaaag agtcaaatcc cagctgtatt tttattaatt atgtaatatt gtacaagtca 4441 ctctctgagc tttggtgtcc ctgtttataa aagtgataga atacattttt gagtgacatc 4501 tgaaagatag cagagtagga agctccaggc cctcctttcc ccatgtaatc tgtgaaagga 4561 aattcaattt cgggacgcca aactcattta gcgaaaggga aaagtcaaag tgggaactgg 4621 gtcatgcaaa cctgcctccc acttttgggt cctcaataag atggctacaa gatgaaaagc 4681 tacatgcctc cgccatattt tgcccacaag gaaattccta gtgagttgtt aaaatttcac 4741 cgtagcaatg caaattgata gcttatcttt acaggtgcag tcgcccccgg cgcactagac 4801 ataaatgcac atctgagtgt tcccctgccc cattttgtcc atgttatctt atgtaaaatg 4861 catattcccc acatttttcc tctgcctctt ttatgtcatc ttattaatgc agattccctg 4921 agccagacaa aggcatgaat gactattttt ccctaccctc ctcttacatg aaaattgtgt 4981 acttctcagt atcgcaccct ttccccttta aattttgagc cctcaaaatc atcttcggag 5041 acaggcatag acctgtctcc tgagtgcatc cttaactttg gcaaataaat cccctaaaat 5101 gattgagact tgtcattttt ctcaattgac atctggtaac cacgaaggga tcctgagtga 5161 aagtgaccca gcctgcagta gctcacctct cagtgcttgg caccggcttg gtcaccttat 5221 agcccaaact gagaggacaa tttgccaaag tcgaggacct ctttccaggg atctctgatc 5281 ttccaacatt ttccagttgg gggtctgaag tttatttgct gttaaaaaca aaacaaaaca 5341 acaaaaacaa caaaaattcc tttttttgta ggcgtttcca ctcacttcca tcaaggaagg 5401 cgagcctgtc tgcttctgca tatgcagaga gcaatcttca gcttgggccc ccatcactag 5461 gtaagaaact ggtttggaat tctgtcttgc aaattctttt aaacgactag aattagcact 5521 aacaaccagc tggtgttaat ttcctgctta cccttagagc gctcagaaat catataattt 5581 gcgtgatcat tgttagtttt gtttaattgt tttgtttctg ggtttgtgtg tgtgtgtgtg 5641 tgtgtgtata tatatctgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtatgtgtg 5701 tgtgtgtgtg ttttggtcct ttcccctatc ggatttgacc aattctgaac cttcaagctc 5761 atgagtgtga aattttccac tctgaagaaa cagaacacat tgctcccctc agccctttgg 5821 ggcattctca ggcgactgag aatcacatga gggtttctgg gagaaatgct ccctaagaca 5881 tgcagcagct ctaaataggt ttccccctca aaagaacata cttagggtct aatctcagcc 5941 agcagatgca tataaggaac tgacccctcc caaactttga gcccctgaca cactgtgcca 6001 ggtggccaca acgctggtgg accaaactgg ttcagggtgt aatggccctg tgaaaagcta 6061 ggtttgcaag cagcacattt tgggtccaac acacatccca acttggtcaa atccaaaggg 6121 gaactctaaa ttatagagaa caaggcctct aagaccccag cagttgcaga atataaagtt 6181 cccctcttag aaactccagc agggtatatg caaaatactt atggtgaatc atcatgcaaa 6241 tatttaacca agcggaccac tataactaaa gcagattcta agttacaatg gcctaaatgg 6301 ggatcttttg agatgcccaa attagtgtac ctgtgaacca ggatggagaa tgcagacaca 6361 aaaaccaaac aaccagaatg ggacagctat tttcagtggt agctgcaaag tagcaaaagt 6421 ggggaagacc actgtcacgc gtgtctgggt gaagtgacca ccaaacaggc tttgtgtgtg WO 00/09525 PCT/US99/17712 EPI-109 905 6481 caacaaggct gtttatttca cctgggtgca ggtgggctga gtccgaaaaa gatgtcagca 6541 aagggagtta ggggtggggc agttttatag gatttgagta ggtagtgtca ggaggcccga 6601 cactcctgtc ttcttatatt aataagaaaa acaaaacaag atagtggcga agtgttgggg 6661 tggcaaaaat tttggggggt ggtatagaga gataatgggc aatgtttctc agggctgctt 6721 cgagcaggat taggggcagc gtgggaacct agagtgggag agattaagct gaaggaagat 6781 tttgtggtaa ggggtgatat tgtggggttg ttagaagcaa tatttgttgt acagaatgat 6841 tggtgatggc ctggatacag ttttgtatga attgagaaac taaacagaag acacaaggtc 6901 cgaataagag aaggagaaaa acaggtatta aaggactaag aattgggagg acccaggaca 6961 tctaattaga gtgcctaagg gggttcagcg tgattattgc ttggttggtc agttttgggg 7021 ctctatcctt gagttttttt atgttgtcac ataccaggcc agattgattt aggtgaaaac 7081 aacactcttc atttaaaaat atagagtccc ctttttttaa gcagtgagta agcggaagtc 7141 tcggtgattt tggaggaaat agaaatgcaa agccagcaat tgtttgttaa agaaggatta 7201 gaaacggcta ggagagagtg agattgatag tgtggtggag atagctgggg agaggtagag 7261 ggtggcataa gaatgggaac gagaataaga gtgagtaaaa aagtaaagaa taggacttca 7321 tcagggtgaa agtaccggac tgtgccttgc cactgaagat cttttatcca cttcaagaga 7381 gatttaaggg tggtggtttg agataaaacc aggagatacc agttatgatg gtttggagga 7441 aaagtgtaaa ctgggagtgt aaacaagggc agggcattta tgagtagttg agaatggtga 7501 ataggagtat gactagacag aagatagtag ggatgacaag tttttggggt gcagtccaag 7561 ttgggctggt gtctggaatg agactggggc ctaataaaaa ggagtgtcca tacaggagct 7621 caaatgggct gtaccctgta gcatcccgag gacaggccca aattctgaga agggcaagtg 7681 gtaaaagtat tgtccagtcc tttttaagtt ggaggctgag cttggtgagg tgtgttttta 7741 aaagaccatt agtccatttt acctttcctg aagattgagg atgggaaggg gtatgaaggt 7801 tccactgaat accaggagcc tgagaaactg cttgggtgat ttgactaata aaggccggtc 7861 cgttatcaga ctgtatagag gtgggaaggc caaaccgagg aattgtgtct gacagaaggg 7921 aagaaatgac cacagtggac ttctcagacc ctgtgggaaa tgtctctacc catccagtga 7981 aagtgtctac ccagaccaag aggtatttta gtttcctgac tcagggcatg tgagtaaagt 8041 caatttgcca gtcctgggca ggggcaaatc cctgagcttg atgtgtaggg aagggagggg 8101 gcctgaacaa tccctgagaa gtagtagaat agcagatgga acactgagaa gtgatttcct 8161 tgaggataga gttccacgat agaaaggaaa tgagaggttc taagaggcgg gctagcagct 8221 tgtaacctac atggaagaag ttatgaaatg atgacagaat agaatgggcc tgtaaggctg 8281 gaagcaaata ttttccttgg tccaagaacc atttgccttg tgtgggaaga gattgatagg 8341 tggaagtttc agcgggggag taggtgggag tgaccaatga aaaggagaaa aactggcagt 8401 gagggacaga agttggaatg ctagctgctt ttttagttat cttattagca taagtgttgc 8461 cttgagcgat gggatctgat gccttttgat ggcccttgca gtgaatgact agcttttttg 8521 gaagtagagc agctttaaga agagttttta ttaaggaggc attaattatg gaggaccttt 8581 gtgtagtggg gaaacttttt tctgctcata taacagcatg gtagtgcagg atatggaagg 8641 catatttaaa gtcagtataa atattaacac atagtccctt tgcaagagtg agggcctgag 8701 ttaaggcaat gagtttggct tgctgagagg tagtggaggg gggcagagca gtagcctcaa 8761 ggatagatgt ggaagacact atagcttagc ctgcctttgc cagtgattgg cgattaggcc 8821 tggtggaact gccatcaagt gtgatcaggg tgaagaacag gaaagaagga aatatgggga 8881 aatggagtga atgccaggtg gatcagagag atacagtcat gggggtcaga tgtggtatca 8941 ggaataatgt gggaggccgg attgaagtcc aggccaggaa caacggtaac tgtgggagac 9001 tcaagaaaga gtaagtacag ctgaaggagc cagggggcag gaagtgtgag gaggaaaata 9061 gattttgaaa gttatgggaa ctgtagaggg ttagtggagc atagcttgtg atttttaggg 9121 cctctaaaag tattaaagcg gcagcaatga ggtgtggctg tagcctagga atagtcaggg 9181 aagcggataa tttagttaaa atgtctcaat ctaataaggg agctgggcag gtggggataa 9241 ctaaaaaaga gtgcataaaa gaatgttgtc caagttggca ccagagttgg ggagttttaa 9301 ggggtttaga agccttgctg tcaataccca caacagttat ggaggcaagg gaaacagtcc 9361 cttaaaaaga aggtaatgtg gagtgggtag cctccatatt gattaagaag gggacggact 9421 taccctccac tgtaagagtt acccaaagtg tctgtgatgg tccaggaggt ttccgaggcg 9481 attaggcaat gtcagtcttc aactgctaag ccacgaatat ctgggaagga gtcagtcaga 9541 gagccttggg ccagagttcc aggggatctg ggagtggctg ccaggcgagt tggacagtcc 9601 aatttccagt ggggtcccgc acagatggga catggcttag gaggaatccc gggctgcggg 9661 cattccttgg cccagtggcc agatttccgg cacttgaagc aagatcctgg gggtggcagt 9721 cctggaggaa cgcctggctg ctgcagttca ggtgttttga agttcttgtg tgctggagat 9781 gtggctgggg tttctctcac agtggaggca agtaattgca actcagaaat acgttgctac 9841 ttggctgcct ctactccatt attgtccaca ttgaaggaga ggttaattaa gtcctgttgt 9901 ggggtttgag ggccggaatc taatttttgg agctttttct aatgtcagga gcaggttggg 9961 taataaaatg catattgaga ataagatggc tttctggccc ttctgggtct agggcagtaa 10021 agcatctaag ggttgttgcc aaacgggaca tgaactaggc tggattttta tatttgatga 10081 aaaagagcct aaccactaac tgatttggga gaggtcagat aaagaaaaag gagaattaac 10141 cttggctatg ccttcagctc cagccacctc tttaagagga aattgttggg caggtcgggg 10201 agggctagtc acagaacaaa actataagct ggaccaggtg tgaggagggg aggtgataaa 10261 aggattatag ggtgggagag cagaggctga ggaagaattg ggacctggct cggcgtggca 10321. aggagcagcc tggggaggag gggagaggtc agataggtcc gtagaaaagg aggattcaaa 10381 ggactcagag cttgggatgg agactgaagg aacaggagag aaagaagaaa gatttgggac 10441 aagtcgcact gggagcagag actaaggagg gatcaatgtg taaaagaatg cctggacgtc 10501 aggcacctca gacccatttg cccatttttt gaccaaaatc atccaggtct tgtaaaatgg 10561 agaaatcaaa agtgccgttt tctggctatt tagaaccatt attgagtttg tattggggcc 10621 aagcagtgtt gcagaagaaa ataagacgct taggttttag gtcaggcgag agttgaagag 10681 gttttaagtt tttgagaaca caggctaagg gataagaaga gggaatggag ggtggaaggt 10741 tgcccatagt gaagaaggca agccccgaga aaatagaggg tagagacatg gagaaggggg 10801 gtggtgagca gccctgggct gcaatgtggg cgagcagcca cagccaaagc aggcgtccct 10861 gcaattgact tgccaccaag ggaatgtggg tgaatgacca aggtaggcat ccctgcggtg 10921 atcagacacc aatggagtgt gggtgaataa tcaggcaggt gtccccgcag tgattaaaca WO 00/09525 PCT/US99/17712 EPI-109 906 10981 ccaagggaag actgtct-cc tgagttcatg actggcgccg gagttctggg tccatggata 11041 aaatgtgtct cctttgtctc tactagagag gaaaaaaac tagaattgga aggacagaga 11101 gattgaaggg tagcgagaga gggagactga agggtggcaa gagaggctgg agaagagagt 11161 aaaaagacca cttacccaat ttgaaattgg tgagatgttc cttgggctgg ttggtctgag 11221 gacccgaggt cataggtgga tctcctcatg gagtgagggc gaggacaggg gactggtctc 11281 ccaaaggagt cctcctgrcc cgggtcttcg gcaccaaatg tcacactcgt ccgtgtgaag 11341 agaccaccaa acaggctttg tgtgagcaac aaggctgttt atttcacctg ggcgcagttg 11401 ggctgagtcc gaaaaaggag tcagcaaagg gagttagggg tggggcagtt ttataggatt 11461 taggtaggta gtggaaaatt acagtcaaag ggggttgttc tcttgcgggc aggggctggg 11521 gtcacaaggt gctcggtggg ggagcttctg agctaggaca tttcacaagg taatgtaatc 11581 agttaaggca ggaacaggcc attttcactt cttttgtgat tcttcagttg cttcaggcca 11641 tctggatata tacgtgcagg cttgggctca gaggcctgac aaccacctca tctccctaca 11701 ggaggccaac aaacaaczca gaaatgctaa ccaagaactc tgtaatcttg tatctctctt 11761 aaagaaatcc tcagaattcc ttacttcccc cttggtacct ccccctacac ccctactcta 11821 ccctgaccaa tctgaacttc ctggaccaga tctgtccgcc gcctctactg catgtctaac 11881 acttgctcaa cagaaggcag ttcagagtct gactgcaaag accccacccc ctcatgattc 11941 cctgacagct ccaatggcaa catctcatct ggaagatgtg gaaaaggggg accgtgcagg 12001 gatatctctc atgatcaccc tattttggga acaactgcta acaggtaggg gaaccctggt 12061 aattgtctac caacaccctg gtcaaaggct gaattccaag gcataaagaa tttcctgacc 12121 cccataaaga tccaattggg tttgagtatt tgagctcatt gtcagaacct atgacccagg 12181 tcattcagac ttttatcagc tagtccacat gttggtctca gaagctaaag ctaaggaatg 12241 gctgggaaaa gcacaatggt cagactctat agcagatttg acccctgaag gcccaatgga 12301 gccacaacaa ccagccccca caaatccaga agacaggcac aaagatgtgc aggaatgagc 12361 aaccactcta ttaaatatca ttccttcagt gttccaaagg gttgtggatt ggaataaaat 12421 ccaacaatgt caccagaacc caaataaatt agttttagat tatttaacac attttgataa 12481 aactttaaaa caacattatg ggatgtcagc tgattgcttt gaaaacaata aaaatgatac 12541 attattaaat gcaaatttct taaacggact agatgatga ttagccaccc ttgtaaaaca 12601 caaattggac cacagccaga actaatgaac tagttaactt agctgaccaa ttatcccgca 12661 ctatgataaa acaaggaaaa acagaagatt gcccaagtta tgcatttaca gctaaagcaa 12721 ttaacttctc aagcctctcg gccccagaaa gattttaagc tccctcggtc tgaggactct 12781 tccctcccag tctgttacaa ctgtaaatga ccgagacacc ttatgatgga ttgccttagg 12841 ctgaaacaaa agaaaaggca gaatgcaact caggaagaca aggggtgctc caaggaaata 12901 caggggtttc acctctccaa atattctacc ctgacaaacc aattggggga gattaatata 12961 ataataaacc atgagtttac aactgcctta actgacatag gtgtgactat ctctgaaaaa 13021 tcccacctta tttagaaacc ccattcctca gagtaatgaa agaatgaaca tggtgggtat 13081 gtctaataaa atgatctcat gttttaagtc caaacccgta ccttagggtt catcaggttc 13141 cactaccctg tcgcaggctc taagtgtgac acactcaga ggtcccatat gtttctaata 13201 tgcactgggg cccctgtcaa acttttgggc tgtgatctca acatccataa tgcccatatc 13261 tctttttcat caaaaggtga aactttttta gaattggagc caggagacca aaaataccat 13321 atttaaaaat gtcctgacaa cgtacaattt agtactaga atgttaaaat gtcatcttgt 13381 gaccaggaaa ataaaataga gacagagaag gaaatattag ggaagaagag agaacattgg 13441 aatacagagc aggaaacagt aaaactcctt ttagtttccc cagtcttcct gttaacacca 13501 gaagcagagc acttgctcaa ggatgtgtcc tcccacttat agtctcagtc aaatacagat 13561 acagagaaag tattctcagc cattccaata aaggtagaga taaatccaaa gaaaccccta 13621 tccaacctta aacactatcc tctgcaaaag gaagccatag atggaattgc tcctgtcata 13681 caagattatc tgagaaacgg gctcattatt ccctgcacaa gcccctgaaa cagccctata 13741 ttccctgtaa agaaactaag cgggagagga tggaaatttg tgcaggaatt gagggcaata 13801 aacaatatca taattctcag gcacacagta gtccccaacc cacaaaccct tctatcacct 13861 atatccacta ccagccagta tttctcagtt gtggatctct gcagtgcctt ctttagtatt 13921 cctgtagaac cagacagcca atatttgttt gtctttattt ggaaagaatg gcaatatacg 13981 tggactataa tgccccaaag gtatacagaa agtcccactt agtgttccca aatattagaa 14041 gctgatttgg agaattaaat attttcccag ggctcaacat tcatctactc tcctttgttc 14101 agacacactc tcttcctctc aggaagatag tctatattta ctcaaacagc caccaaggga 14161 cacaaatgtc taaagacaaa cttcagctat gcttacctga agttaagtat ttgggacata 14221 ttatctcagc caaaggactg agtattaacc ctgatagagt gaggaatttt agctttccca 14281 atgcccgtca ctaagaaaca acttagagta ttttggggcc tggcaggcta ttgtagaaac 14341 tggataccaa atttctccct tatggctcaa cttcagtgta catacctaaa aaatgaacaa 14401 cctgatccca tcatgtggac tccggaggga caatcagctg tacaacaaat aaaggaaatt 14461 ctgactaatg ccccagcctt agggcacccg aactacaaat tgcctttctc ccttttcata 14521 cacgaagttg gaggtacgc atccggagta ctgacccaga aacatggtga tcatcagaga 14581 cctataggct attatagcca acagctggac cctgtggctc aagggctgcc tccctatgtg 14641 agagcaatag cagccacggc ccttccgtat aagtctgttg aagaaataat tataggttcc 14701 ccccttaaca tttttgtgcc acattctctt gagacccttc taaactctca tcatacacaa 14761 cacctgtctg tcaactggtt agcctcttat gaaattttgc ttttatcatc tcccaatatt 14821 actagttcct gctgtaataa tcttaatctg gccactctct gccaggccc ttctgacaaa 14881 accccctcat gactgtgttt tgatgactga cttctcaccc ccaggacaga cctacaagag 14941 atgccactgg ataatgctga gatagaatgg tatacagatg gatcttattt aagaggagag 15001 gatggaaatt ttatagcagg atatgctgtg gtttccttac tagaggtaat tgaagccaat 15061 cctctccccc aagccagatc agctcaagtg accaaattgg ttgccctgac cgaagcttgt 15121 caattggcaa aagacaaggc tgcaaacatt tacactgaca gccacatgc ttttggggtt 15181 gctcatgact gggatgttat ggaaagagag aggatatta accccctcag ggcaaccca 15241 aaaaaatgga caagtatcag agttgttaga agctgttcta acaccaaaac gcttggcaat 15301 tataaaaatc ccaggttggc caggcgcagt ggctcacacc tgtaatccca gcactttggg 15361 aggccgaggc aggaggatca cgaggtcagg agatcgagac catcctggct aacatggcga 15421 aaccccgtct ctactaaaaa tacaaacccc gtctctacta aaaatacaaa aagttagccg WO 00/09525 PCTIUS99/17712 EPI-109 907 15481 ggcgtggtgg tgggcgcttg tagtcccagc tactcgggag gctgaguag gagaatggca 15541 tgaacctggg aggcagagct tgcagtgagc cgagatggcg ccactgcact ccagcctggg 15601 caacagagag agactccgtc tcaaaaataa ataaataaaa ttaaaaaaaa atcccaggtc 15661 actcaaaatt agacaccaca gtaagtcagg gtaaccaatt tgctgaagcc acagctaaaa 15721 gagcagcatt caagccatca gccccaagtt ggaaaatggc cataaaaccc aaaacactta 15781 aatacatgtt gaaagaaacc cagagcatag ctcctacaaa agagaaatct acttggaaac 15841 aggcaggggg atacttgtct cccaaaactg aaatatggtg tggacctaat tattccattc 15901 caagaaaccc attattccaa tggaatgtca ggtgtccctt atgaaatatg ttcataatct 15961 aacccattgg aatccagata aaataatatc ctggtgtaaa caatattact ggaaaccatc 16021 cttcacagtg gcacaaaaag tttactctca gccgggcacc atggctcaca cctgtaatcc 16081 cagcactttg ggaggcccag gcaggtagat cacctgaggt caggagttca agaccagcct 16141 ggctaacatg gcaaaaccct gtatctacta aaaatacaaa aattagccag gcatggtggt 16201 gcgtgcctgt aatcctgctt cttgggaggc tgaggcagaa gaatcgcctg aacccaggag 16261 gcagaggttg cagtgagctg agatcacgcc attgcactct agcctgggcg acaagagcga 16321 aactccatct caaaaaacca aacaaaaaag tttactctca atgtgttatc tgtcccaaac 16381 ataacccagg aaaacccctc catggggccc agggtcattt tccccttccg gctgaccttt 16441 tgaggtatga cagcttgatt ttatccagct gccatcatct caatgttaca agtatgtttt 16501 agtaatggtc tgcatgtttt atcattgggt tgaagctttt ccctgcaggc aagcaacagc 16561 cacgacagtt ggaaaaatcc tactagaaaa aattgtccca ctgtggggag tcccctgtga 16621 acttcacagt gatgggggat catactttac tggccaggtt actcaaaata tttgtaaaat 16681 ttggcccata tttcaacatt tccattgtgc caccatcccc agtcttcagg cctggtggag 16741 aggaccaatg gaataattaa aacacaattg gctaagttca cagaggcatt tcacctcccc 16801 tggcccaaag cactacccct agtgctgctt atactacgat ccactccttt tggaaaacat 16861 caactgtctc cttatgaaat tataacagga aggcccatgt gtatgggaac gaacataacc 16921 aatccaactt ttctccaggg agatatattg caatattgtg agggactcat ttatcatctt 16981 agaaaaaacc aaaatttgtt aaaaaattcc tttcacggtg cgctccccga agataaggtg 17041 cctggtcatc tgcaacctgg agatttcatc tattggaaaa gacatctaat aaaggattcc 17101 cttcaaccct gatggaaggg cccgtaccag gcactactga ctaatccatg tactgcaaaa 17161 ttaaagagta tagattcatg gattcacatc tctcatctta aaaaggcaca acctcctgag 17221 tggactgtaa ctcccaccaa agaccttcac ctccggttca ctaaacatca acctgcaacc 17281 caggattaga agcagacaac agctgttgtg gactgcttaa acccaagaca cagaaccagg 17341 cctgtataca aagggaacgc ctctgtttat tgtacagtaa ccattacaat tattgtccta 17401 gatataccgg caactgctgt cttataaatg acagggcact tgccttgtct gatttaacac 17461 catttagtaa ctaaaatgaa tttcgcaacc ttgctattat taatcctata tccctacact 17521 ttcttgccac tgccacccac tgatgcccat gaaacaaacc tgtttctaca atgggctcag 17581 cattatgcag acaaattaca aagaacacct gctggatatg cagactcatg cctctttcca 17641 gtggctccag cctgccatgg tggatatccc ccttccaagg tcaggactgg atagaatacc 17701 aaaaatttat cacatcacag aaatggtctg gtattcttag tgctgggata acaaaagaca 17761 atacatacaa ttggcccatt aaaaacactc ttaagaacaa gggacatggg aaaagatttt 17821 gaatggaaag gaccaggtca ttagctctca ctttagcatc cccccagcta aaacagaagg 17881 tggtaaccac accccaaaca acagctcatt ttcaaaatgg aataatgcaa atttgggctg 17941 gatttatctg gctcacccgt tcgtctggcc aactcagcca aaattctcct ctgtgctggg 18001 agaaagaaac catatcaagg acctatggcc aaacagtacg agagatacgg ggtggacacc 18061 tggagaatgc tgtgaccaca ttatcatatt acaagacgct gactggaatg ccaccgattg 18121 ggtgcagcaa tcaggtattt attggatagc tccaaatggg acatattggc tatgtggcac 18181 taacttatgg ccgtggttac ctctagggta gttaggatga tgttccctag gttatgcttg 18241 ggcacaagac acgtaatcca gaccctgcca aaaccagcaa acctttttca tttacaattt 18301 cattggacat gttaggtatt ccaatggtat gatcacttag ctttaatctt tgtaccacag 18361 acaggtattg aagatgttat atggcatata gaggccttac ccaattacat ccaaaaggcc 18421 ctgaatgata gccacatgag tattgccttg ctaagcaatg aggtcatgct tatgaggaaa 18481 gttgtgctat acaaccatat ggctttagat atactcattg cagcacaagg ggggacctgt 18541 gccgtcataa aaactgaatg ttgtgtgtat attcagatga attgaagaac ataactcgat 18601 ttatgactga tatgaaaacc cagataacca acctgtcaga tctaaaaccc tcactaatca 18661 attggttgag tagttggttt ggatcctggg gaacttggtg gcagaagcta ctgcttataa 18721 taggaataat aataatttgt gttctgtcct gtttctgcta caatgttgtt acggtatgtg 18781 cttgcaaata agttaatgca caactgaaag ggctggggta ataattgccc agagaattgc 18841 tttaattgag gaagcagtaa tatagcttga cccagcttca aggtttgctt tccttttgtt 18901 gctataaata tgacctaggt ccctatatat atattttttt ctttttcttt tttcctttcc 18961 tttttccttt tttcctctcc cttttttttt taaatattcg tgggacacaa tttcctagga 19021 atgagccttc ctagcgacaa tgggcgtgac ttcctaggaa tgagccttcc tggtgatgtg 19081 ggacctaaac ttctagaaat aaactatcct agcaacagga aaccagttca gaaaagggag 19141 gaaaaatcaa cctgtagcca agaacccata ttccttttaa aatgcttcct tcaaaagatt 19201 ttaaataaaa aaagagggga aacctgaaag gaaattaaat tttgggaccc cccaaactca 19261 tttagcaaaa ggcaaaagtc aaaatgggaa ctgggtcatc caaacctgcc tccccctttt 19321. ggttcctcaa taaaattgtt acaagatgaa aagctacatg tctcctccat attttgccca 19381 cagagaaatt tctagtgagt tgttaaaatt tcaccatggc aatgcaaatc gatagcttat 19441 ctttacaggt gcagtcgccc ctggcccacc agacataaat gcatatctga gtgttcccct 19501 gcccaatttt gtctatgtta tcttatgtaa aatgcagatt ccccagattt ttcctctgcc 19561 ccttttatgt catcttttat ttatttattt atttatttat ttatttactt atttattttg 19621 agatggagtt tcgctcttgt tgcccaggct ggagtgcaat ggcacgatct cggctcacag 19681 caacctccgc ctcctgggtt caagcaattc tcctgcctca gcctccagag tagctgggat 19741 tacaggcatg caccaccaat cccagctaat ttttgtattt ttagtagaga tggggtttct 19801 ccatgttggt caggctggtc tcgaactcca gacctcaggt gatccacccg cctcggcctc 19861 ccaaagtgct gggattacag gcgtgagcca ccacgcctgg cctttt-gtt gttatttagt 19921 tttatttcat atcataaact taactctgca atccagctag acatggaaag gaacaaggaa WO 00/09525 PCT/US99/17712 EPI-109 908 19981 aacatggaac ccaaagggaa ctgcaatgag agcacaaaga ttataggcta ttgccagcaa 20041 atggggtgga ggggtgctct cctgagctac agaaggaatg gtctggtggt taagataaaa 20101 cacaagtcaa actttaataa gttgtccata gtcagcaatg gtgatcttct tgctggtctt 20161 gccattcctg gacccaaagc attccatggc ccccacaata tttatgcctt cttttacctt 20221 gccaaagacc acatgtttgt catccactca gtcttggcag tgcagatgaa aaactgggaa 20281 ctgtttgtgt ccagcatttg ccatggacaa gatgccagga cctgtatgct ttaggatgaa 20341 gttcttgtca tcaaatttct ccctgtagat ggacttgcca ccagtgccat tatggcaatg 20401 tgaagtcacc accctgacac ataaaccctg gaataagtct gtgaacgcag gaacccttat 20461 aaccaaatcc tttctctcca gtgtgcacag catgaaattt ttctggtgtc ttggaaactt 20521 gtctgcaaac agcttgaagg agatgtggcc caagagccca ccatctatgg tgatgttgaa 20581 gaacaaggtg gggttgacca tggctgatag tacggggctc ctggcagcag cagcatctgt 20641 gaagtggcca ttctatgtta tcttatattt aaaaaatgca gatttgctga accagacaaa 20701 ggcatgaatg actatttttc cctaccccct cttacatgaa aattgtttac ttctcaatat 20761 cctacccttt cccctttaaa tttgaagccc tcaaaatcac cttcggagaa aggcatagac 20821 ctgtctcctg ggcacgtcct taactttggc aaataaatct aaaatcattg ggacttattt 20881 catcattttt ctcaattgac aaaacattta aaaaataata cagactggac ccagcctgcc 20941 caactcccag tggagagcaa ggtttccttc tattttcata ggcaaccaga acaatgttct 21001 atgcacattt tgtcctcagt aagagggcct ctggccaaaa tttggctagc ggcccattgg 21061 gataagaagc taaccaaagc ccctgtgtta cagtgtaatt tagagagcag catggagagt 21121 atcatctcac caaaggtgaa gatagcatta cggacatcag gacatctctt actgggagta 21181 gtttgaatct atcacaggaa agccaaatat cttcttgcag actgtaatga agcattcatt 21241 aagataaaga tggctttttg atcaggtgtt gacctgcctg aggaaaatca ggaagcagct 21301 tataacacca ttactttact tgaataattt catgactttg atcagccact gcctgactta 21361 gatgacatcg atgtggccca gaagttcagc ctgggtcaga gtagagtgga agaaataacc 21421 gtgagagaag aagttgggaa tatcagtatt ttacaagaaa atggttttgg cgattttgga 21481 atggatgatc attgagatca gagaaagcag tgcttttgag gatgatgaca tgttagtagg 21541 cactactgct tctaatctcc tattagagtc tgaacagagc accagcaatc tgaatgagaa 21601 aattaaccat ttagaatatg aagaccaata taaagataat aattttggag aaggaaatga 21661 tggtggaata ttagaagaca aacttattag taataatgat ggtagtatct ttgatgatcc 21721 ccctgccctc tctgaggcag aggtaatgtt gccagagcag cctgcacatg atgatatacg 21781 ggtgaggatg ataatacatc aatgggtggg cctgatagtc ctgattcagt gaatcctgtt 21841 gaaccagcca actatgactg atcaaacaac acttgttcca aatgaggaag aagcatttgc 21901 attggaacct attgatataa ctgttaaaga aacaaacgcc aagaggaaga ggaagctaat 21961 tgttgacagt gtcaaaaact tggatagcaa gacaattaga gcccagctta atgattattc 22021 tgatattgtt actactttgg atctggcacc acccaccaag aaataggtga tgtggaaaga 22081 gacaggagta gtagaaaaac tgttttcttt acctgctcag cctttgtgga ataacagact 22141 actgacgctc tttacatgct gtcttacacc acttgtacca gaagacctta gaaaaagggg 22201 gaaaggaggg acagataatt tggatgagtt cctcaaagaa cttgaaaatc cagaggttcc 22261 tagagagaac tagcaacagc tacaccagca gcatgatgtt attgataagc ccattttgga 22321 agagccaagc catctccaga agtcagtgat gaggccagca gaacaaatct ggatgagtca 22381 gctatgcctc caccaccacc tcagggagtt aagtgaaaag ctggacaaat taacccagag 22441 cctgtgatgc ctcctcagca ggttgagcag atggaaatac tgcctgtaga gcttccccaa 22501 gaagaacctc caaatatctg tcagctaata ccagagttag aacttctgcc agaaaaagag 22561 aatgagaaag aaaaggggaa aaaaagatga tgaaggggaa aaggatgaag atgtttcagg 22621 gggtgatcaa gatcaggaag aaagaagatg gaagaaaagg actcagcaga tgcttcacgg 22681 tcttcagtga gctcttgcta aaactggagc tgaatctatc agtttgcttg agttatatca 22741 aaacacaaac agaaaacaaa ctgttgcaaa gttctacagc ttcttggttc ttaaaaagca 22801 gcaagctatt gagctgacac aggaagaact gtacagtaac atcatcgcaa cacccgggcc 22861 aaagttccat attttatgag gagctagaag cattatagct agtgttcatt tcactagtgc 22921 ttacaaattg cccccatgtg taggagacac agaacccttt gagaaaactt agatttttgt 22981 ctgtacaaag tctttgcctt tttctttctc attttttccc agtatattaa atttgtcagt 23041 ttcatctttg agggaaactg attagatgga tgtgtttgtg ttctgatgga gaaaacagca 23101 ccctaaggac tcagaagatt aacagttcag aacagatgtg tgcaatattg gtgcatgcaa 23161 tgatgttgag tggcagttga aagtcatgat ttttatctta gttcttcatt actgcattga 23221 aaaggaaaac ctgtctggga aaatgcctga cagtttaatt taaaactatg gtatgagtct 23281 ttgaaaagaa aaaaaaaaag cctttccatc agtagtaaca ctggcaatct tcttgttaac 23341 cactctcctt agggatggta cctgaaataa caaaggtcac cctcttgaga ttcgttttaa 23401 gtgtaattcc ctaatgagca aacgtgtacg tgaaattgtg ttgtgactga tacccttcag 23461 ctacagatag gactgacttg gtttaaagtg ttctattttg taaatcattc catttgagtc 23521 tttctgatga acttcgctat ctcgaaatct gtcattttag tgaggctcca aaatgagcag 23581 aaataggcct gattagagta gagtgactat caaatagcag actttctagg acctataaat 23641 agaagtttta aaaagatgtt tggatatatt tgactattca gatcatgaaa acagaaatta 23701 ccctgcctac tacaaggaca gactgatggg aaattataca ccaggtcaac ttaaccttta 23761 agcagacaat gctgtaaaaa ctaatggctt ctctgatatt tattgtaagt tttagtactg 23821 atctcctttt ccagtgctgc acactcctgt gtttggaact ttaatagctt tgcaacgaaa 23881 tcctatatcc ggtttcctat aatttaactg aagaaaaaca catccaaata aaggtctata 23941 ttaacagacc agatagcatc agaaatcatg tgactattat gattatcaga atatgtctta 24001 actttttagg gcaaaattaa cactgaaagt tctagcttaa gtgttgacac tttcgtgggg 24061 aaaaaaatca cttttgaaac agacttcagt gtatactcaa taatttaaaa ttatgtgaaa 24121 tgttttaaat ttgtgaactc attactgttt taatgattcc gtttcttgag agtttaacca 24181 taaaaaattg ctattgcaga tttattttca atatgctgtg cctgtaaacc atggagtttt 24241 ccctgtttgt aaaaagacat tgtagataat tgaatgtttg attttagaaa ggtcattggt 24301 ttcttgttac acattttgtt agtctgtttt ttttgcttat tgggtttaat attgttcttg 24361 aaaatagttg atgctatgtt atgtataact cttctaataa aagttgtgtt ataagttgaa 24421 acaaattata gtattacaga ctggctacaa taactttata ggaagtctga aaaatactca WO 00/09525 PCT/US99/17712 EPI-109 909 24481 aagttctata gcaaccaagc aaacacctag tcaagaaaac gatacagtca aaatggttag 24541 aaattttgtg acattttta'c ttgcctgtac cccatccttc cctcctggca cacctgggga 24601 agcagcagcc ctgctcccaa ttccctccct ggaaccccag agagaggaaa gtggacttta 24661 tttgcaacat tctaacctgt caaggggctg cctgaggtac tggtctctgt tttacctaat 24721 tcggaggtca gacagggaaa agcaacatgg ctggatactc aggctcagga aaagccacag 24781 gaaatgatgg gcactactca tgaacactgc agggggccta caaactcaca gatacctgga 24841 gcaagagatc agaagtagaa gaatacaata gaacatctaa gcccaccttc tgagaagcag 24901 aggtgagact ctttaggaaa ttgagacatt ttaagcagtc atgcattcaa gggaactgga 24961 aaacaacaac aacaacaaca acaacagata cccaggccaa ggcaaaatgc atagccaaaa 25021 gaggtctaag aagaccttaa gacctcacat ggggctgatc ccaaagctga cagcatgccc 25081 tgctaattag tgaaggtctt ccctggcaca gaacctactt gtaatgacta gcagaggtgg 25141 ctgttttttt gaatgatcaa ttttaaaaat gaacaaaaaa ataacaaacc atgcaaagaa 25201 acaggaaaat atggcccatt caaaggaaga taataaactg tcagaaactg tccctgaaga 25261 aacacaagca tcagaagtac tagacaaaga caaaatgtct taaatatgct caaagagcta 25321 aatgaaaact caaagaacta aaggaaatga gaaaaatgac acataaacaa aagagaatat 25381 taacaaagag aaactataaa aaggaaccaa acagaaattc tggagctgaa aatacagtat 25441 ctgaattgaa aaacgcctag agggattcaa cagtagattc aaacaggaag aaaaaagaat 25501 cagtgaactt gaagataagt cctttgaaat tattgaatct gaagaccaaa taataataat 25561 aataattaag aaaagtggac agagactaag agacctatgg gataccatca agctaaccaa 25621 tatatgcatt acagaaatct cagatggtga cgggataaag aaaggagcag aggaactatt 25681 tgaaaaaata atggctgaaa acttcccaaa tttgaggaaa ggcattgatt cacaaatcca 25741 aaaatcttgc tgatctccag gtaggataaa cccaaagcag tacataccaa gacacattat 25801 attctaacaa aagccaaaga catggaacac tgcaggggga ctacagactc acagaaaccg 25861 ggggcaagag atcagaggta aaggaataca atacaaagtc taaggccccc tcaagaatct 25921 tgaaagaagc aagagaaaag taactcatca tgcacaatgg atcttcaata acattatcag 25981 tggatttctc agcaaaaacc ttgaaggaca caaggaattg aataccatat ttaaaggaaa 26041 ttttttaatt gttatttttc cataagttat tggagttcag gtggtatttg gttacgagta 26101 agttatttaa tggtgatttg tgagattttg gtgacctgtc accgaagcag tatacactgc 26161 actgtatttg tagtctttca tccctcaccc acctcccact cttccctcca agtccccaaa 26221 gtccattgta tcattcttat gcttttgtgt cctcatagct tagctcccgc atatcagtga 26281 gaacacgtga tgcttggttt tccattcctg agttacttca cttagaataa tagtctccaa 26341 tctcatccag gtcactgcaa atgctgctaa ttcattcctt tttatggctg cacagtattc 26401 catcatatat atataccaca gtttctttat ccacttgttg attgctgggc atttgggttg 26461 gttccatgat tttgcaattg tgaattgtgc cgctataaac atacatatgc aagttatctt 26521 ttttgaataa tgacttcttt tcctctgggt agacacccag tagtgggatt gctggatcaa 26581 atggtagttc acttttagtt ctttaaggaa tctccacact attttccata gtggctgtag 26641 tagtttactt tccaccagca gtgtggaagt gttccctgtt taccacatcc acaccaacgt 26701 ctactgtttt ttttattatg gccattcttg caggagtaag gaggtattgc attgtggttt 26761 tgatttgcat ttccctgatc attagtgatg ttgagcattt tttcgccatt tgtgtatctt 26821 ttgagaattg tctattcatc tccttagtcc actttttgat gggattgtgg gtttttcttt 26881 cttattgatt tgtttgagtt cgttgtagat tctggatatt agtcctttgt cagatgtata 26941 gattctgaag cttttctccc actctgtggg ttgtctgttt actctgctga ctgttccttt 27001 tctgtgcaaa agctctttag tttaattaga tcccagctat ttatcttttt attgcatttg 27061 cttttgggtt cttggtcatg aaatccttgc tgaagccaat gtctagaagg gtttttccaa 27121 tgttatcttc tagaattttt atagtttcag gtcttaggtt taagtcctta atccatcttg 27181 agttgatttt tgtataaggt gagagatgag gatccattgt cattctccta catgtggcta 27241 gccaattacc ccagcaccat ttgttgaaaa aggtgccctt ttcccacttt gtttttgttt 27301 gctttgttga agatcagttg gctctaagta tttgggttta tttctgggtt ctctattctg 27361 ttccattggt ctacgtgcct atttttatac cagtaccaca ttgttttggt gactatggcc 27421 ttatagtata gtttgaaatc agctagtgtg atgcctccac atttgtcctt tttgcttagt 27481 cttcctttgg ctatgcgggc tcttttttgg ttccatatga ttttgggaat tgttttttct 27541 aattctgtga agaatgatgg tggtattctg atagagattg cattgaattt gtagatggct 27601 tttggcagta tggtcatttt cacaatatta attctaccca tccatgagca tgggagatgt 27661 ttccatttgt ttgtgtcata tatgatttct tacagcagtg tttgtagttt tccttgtaaa 27721 ggtcttttaa ctcattggtt aggtatattc ttaagtgttt tttttttttt tttgcaacta 27781 ttgcaaaagg ggttgagttc ttgatttgat tctctgcttg gttgctgttg gtgtatagaa 27841 gagctactta tttgtgtaca ttaatcttgt atgcagaaat tttgctgaat tcttttatca 27901 gttctaggag ctttctggag gagtctttag gggtttcaag gtaaatgact gctatatata 27961 aagtttcagt ggcacaaaag aaatagcact caaatataaa attttctttt taattctcag 28021 caaggctagt tacttctcta tagaagggtg tgcccttaca gatggaacaa tggtgagcgc 28081 acacttggac gaggggaagg gattcttatc cctgacacac atggcccctg ctgctgttgt 28141 tcccctattg gctagggtca gaccgaacag actaaactaa ttccgaccag ctaatttaaa 28201 gagaatgacg gggtgagtgc tttggaggga gtcagggcag agcaggtagc aggtaaatgg 28261 aatgagttag ggtggagcag gtgattggaa tgtagggtgg agcaggtgat cagaatgagt 28321 cagggtggag taggtaaccg aaaaaggttg ctttacgagg aagttaagtt taaaagtaga 28381 aggcaaagaa ttgaacatac tgacatatta attcttcgaa aagaaattta gaactcatat 28441 ctaacatgat catatcatca gcaaacagtg acagtttgac ttcctcttta ccaattggat 28501 gccctttatt tctttctctt gtctgactgc tttggctagg acttccagta ctatgttgaa 28561 gaggagtggt gagagtgggc atgcttgtct tgttccagtt ctcagaggga atggtttcaa 28621 cttttcctca atcagtatta tgttggctgt gggtttgtca tagatggatt ttattacatt 28681 aaggtatgtc ccttgtatgc cgattttact cagagtttta atcatatagg aatgctgggt 28741 ttcgtcaaat gctttttctg catgtattgt gatgatcatg tgatttttgt ttttaattct 28801 gtttatgtgg tgtataacat ttattgactt gtgtaggtaa aaccatccct gcgtccctgg 28861 tacaaaactt acttgatcat ggtggattat ctttttgata tgttgttaga actggttagc 28921 tagtattttg ttgaggattt tagcatctgt gttcatcaaa aatattggtc tgtaattgtc WO 00/09525 PCT/US99/17712 EPI-109 910 28981 ttttttggtt atgttctttg ctggttttgg tattaggatg atgctggctt catagaatga 29041 attagggagg gttccttctt tctctgtctt gtaaaatagt gtcaaaagga ttgataccaa 29101 ttctttgaat gtctgctaga agtctgctgt gaatccgtct ggtcctggac ttttttttgt 29161 tggtaatttt cttaattacc atttcaatct cactgcttgt tgttggtctg ttcagggtat 29221 cttatccttc ctgatttaaa ctaggagggt tgtatttttc cacgaattta tccatctctt 29281 ctgggttttc tagtttatgt gcataaaggt attcatagca gccttgaatg atcttctgtt 29341 tctgtggtgt cagttgtaat atctcccatt tcatttcttt cctttttttt ttttttgaga 29401 tggagtctca ctctgtcccc caggctggag tgcagtggtg ccatctcagc tcactgcaac 29461 ctccactcct gggttcacgc cattctcctg cctcagcctc ccgagtagct gggactacgg 29521 gcacccacca ccacgcccag ctaatttttt ttctgttttt agtagagaca gggtttcact 29581 gtgttagcca ggatggtctc gatctcctga ccccatgatc cgcccacctc agcctcccaa 29641 agtgctggga ttacaggtgt gagccaccgc acccggccct ctcccgtctc atttcttact 29701 gagcttattt ggattttctc tcttctttac ttggttaatc ttgctaatgg tctatcaatt 29761 ttatttgtct ttcaaagaac cagcttttca tttcatttac cttctgtatt tttgttcatt 29821 tcaatttcac ttagttctgc tctgatcttg gtgatttcct ttcttctgct gggtttgggt 29881 ttggtttgtt cttgtttctc tagttccttg aggtgtgacc ttagattgtc tgtttgtgct 29941 ctttcagact ttttgatgta ggcgtttagg gctatgaact ttcctcttag cactgccttt 30001 gctgaatccc agaggttttg atagttgtgg cattattgtc attcagtttg aagagttttt 30061 aaatttccat cttgatttca tttttgaccc aatgctcatt ctggaccagg ttatttaact 30121 tccatgtatt tgcatggttt tgaaggttcc ctttgaagtt gatttccagt tttattccac 30181 tgtggtctga gagagtgttt gatataattt caattttctt aaatgtattg aagctcattt 30241 tatggcctat catatagtct atcttggaga aagttccatg tattgttgaa tagaatgttt 30301 tattctgcag ttgttggatg aaatgttctg tatatatctg ttaagtccaa ttgttccaac 30361 gtatagttta aatccattgt ttctttgttg actttctgcc ttgatgaact gtctatggct 30421 gtcagtggag taatgaagtc ctccatgatt attgtgttgc tatctatctc atttcttagg 30481 tgtattagta actgttttat taattttgga gttccagtgt taggtgccta tatgtttagg 30541 attgtgatat tttcctgttg gaaaggcctt ttaccattat atactgtccc tctttgtctt 30601 ttgtaactgc tattgcttca aagtttgttt tgtctaagaa tagctacccc tgctcgtttt 30661 tggtgtccat ttgcatgaaa tgcctttttc caccccttta ttttaagttt atgtgagtcc 30721 ttatgtgtta ggtgagtctc ctgaaggcag cagatagttg gttggtgagt tcttattcat 30781 tctgcagttc tgtatctttt aagcggagca tttagaccat ttatattcaa tgttaatatt 30841 gaaatgtgag gtactgttgc tttcatcatg ctctttgttg cttgtgtact ttggtttttg 30901 ttgtttttgc tttttaactt atatttttgt ttcataggtc ctctatgatt tatgctttaa 30961 agaagttctg tttttatgtg tttccaggat ttgtttcaag atttagagat ccttttagca 31021 gttcttgtaa tggtggtttc ctaatggcaa attctctcag catttgtttg tctgaaaatg 31081 actgtatctt tccttcatat atgatactta gtttctctgg atacaaaatt cttggctgat 31141 aattattttg tttgaggagg ctgaagatag gtccccggtc ccttcttgct tgtagggttt 31201 ctgttgagaa atctgctgct aatctgatag gctttccttt ataggtaacc tggtgcttct 31261 gtctcacagc tcttaagatt ctttccttgg tcttaagttt ggataacctg atgacaaagt 31321 gcctaggtga atatcttttt gcgatgaatt tcccaggtgt tctttgtgct tcttgtattt 31381 ggacatctag gtctctcgca aggccaggaa aggtttcctc gattattccc ttaaacatgt 31441 tttccaggct tttagaattc tcttctttct caggtacact gattattct aagtttggtc 31501 atttaacata attccagatt tcttggaggc tttgttcata tttccttatt cttttttctt 31561 tgtctttgct ggatggggta attcatagac cttaaagctc tgaatttctt tattctactt 31621 gttcagttct attgctgaga ctttccagag aatttcacat ttctgaaagt gtgtccaaag 31681 tttcctgagt ttttgactgt ggtttcttta agctatctat ttccatgaat atttctccct 31741 tcacttcttg tatcattttt tgaacttcct tgtattgggc ttcgcctttc tctggtccct 31801 ccctgattag cttaataact aacctcctga attctttttc aggtaaacca ggtatttctt 31861 cttggtttgg atccattgct ggtgaagtac tgtaattttt ggggggtgtg gaagagcctt 31921 gtattgtcat attactgggt atctcagccg tggataccag cacctgttcc aatggaggtg 31981 gcggagggtg caatggactc cgtgagggtc tttagttttg gtgatttaat gctctatttt 32041 tgtgctggtt ggtctcctgc caggaagtgg tgctttccag aaacatcag ctgtagtagc 32101 gtggagaggg actggtggtg tgcagggccc tagaactccc aagattatat gccctttgtt 32161 ttccactacg agggtggata aggaaggacc atcagatggg ggaagggcta ggcgtgtctg 32221 aactcagact ctccttgggt gggtcttgct aaggctgctg tggaggatgg gggtgagatt 32281 cccaggtcac tggagttgtg cacctaggag gattatggct gtctctgctg agtcatgcag 32341 gttgtcaggg aagtggggga aagccggcag tcacaggcct cacccagctc ccacacaaac 32401 tgaagggcag gtctcattcc caccgtgccc tgaccaacag ccccaagtct gtttccatgc 32461 ggagagtgag aagggcttga aaacttgctc aaggctatct gcctcccagc tgtgagagaa 32521 aagggcttta attcttctcc ctgcctgtga agtatgcatg cccaattcac gccctccgct 32581 gagttctggc caggaggctt ctcgccacat tcaaattgtt acaaagttca gctagagaat 32641 tccttctccc tgtggagttt caccccctgc tcctctggcc gatggatccc tgtggtgcca 32701 ggcaggaatg ggctgcttgg gtcccagcaa gttcctgggt cctctacctc tgtatttcac 32761 tcggctctct aacttgactc agctccaggt aaagctggaa acttcacctg caaacagacc 32821 ttcagcctct ccagtggggg tgtgtcttca ggagaggagg gtctaccttt cccacttccg 32881 cagttgggaa actcacagga attttttttt tttaatgtca acagataatt ctacatcttg 32941 gaaaactgcc cttcagaaat gagggacaaa ttaagacatt ccaagataaa taatagtcaa 33001 cattgcatgg gaatttttgg ccagaacaat taggcaagac agaaacaaaa ggcatccaaa 33061 ttggaaagga agaagtaata ttatctctgt ttgcagagga tatgatctta caggtagaac 33121 actgtaaata tttccccaaa atcactgtta gaactagtaa atgaattcag caaaaatgca 33181 gaatacaaaa tcaacacaca aaaatgagtt atgtatctat attggcatta aacaatctga 33241 agaggaaatt aagaaaacaa ttccatttac agtagcattg aaaataataa tattcttaga 33301 aataaactta accaaagagg tgaaagactt gtacacagaa aactacaaaa tgttgctgaa 33361 agaagctaaa gaagacacaa atagatggaa atacatccca tattaatgag ttggaagact 33421 taaaattgtt aagatgtcaa tactacccaa aqtgatctac aaattcaatg caatccctat WO 00/09525 PCT/US99/17712 EPI-109 911 33481 tattaaataa aatcctaatt atgtttttgc agaaatagaa aaatcaaccc taaaattcat 33541 atggaaattc aaggaatcgc aaagaaccaa aacaatttcg aaaaaaaaaa atttttttta 33601 acttggtggt ctctcacttc ctgatttcaa aactacaagc tacagtaatc aaaaccatgt 33661 ggcataaaga cagacataca gactaatgga ataataaaga gcccagaaat aaacccttgc 33721 atatatggtc aaataattct caacaagggt gccaagacca tccaatgggg aaaagaaagt 33781 cttttcaaca aatggtgctg ggaaaactgt atgtccacat agaaaaaaat gaagttggac 33841 ccttaccttg caccatgcaa aaattaattc aaattcaaat tagattaaag acctaaatgt 33901 aagagctaaa actataaaac tcttagaaga aaacataggg ggaaattttc gtaacaagat 33961 ttagcaaaga tttcttgtat ctgataccaa aagtacaggc aacaatttaa aattatatga 34021 gttggactcc atcaaaatta aaaacttttg tatatcaaag gacactatca gcagagtgaa 34081 aaggcaaccc acagaatagg agaaaatatt tgcatatcat atatgtgata agggactaat 34141 atccagaata tataaagaac tcctatgact caacaacaaa aaaaacaaac aacctgattt 34201 aaaaatgggc aaagaacctg aacttcaaag aagttataca aatgaccagt aaacatatga 34261 aaagatgttc aacatcacta accactagag aaatacaaat caaaaccata atgaaatacc 34321 atttcacacc ccctaggatg gctattataa aaaacagaaa ataacaaatg ttggcaagga 34381 tatggagaaa ttggaactct tgtgcattgc tgtaggaatg taaaatggtg caaccactgt 34441 caaaaagagt atgacagttt ctcaacagat caaacataaa attaccatgt atattagtca 34501 aggttctcca cagagacaaa accaataggc tatatataga gagaaagata caagagggga 34561 tttattaggg gaattggctc atgtgattat ggaggctgat aagtcccaca acaggctttc 34621 tgcaaattgg agaccttaga atgccagtag catggcccca ttcaagtctg aaggcatgag 34681 aacccagggg gctgctagag tccaaaggat aaagagcctg gagtgctgat gtctaagggc 34741 aggagaagag tgtatcccac ctgcaagagc gagaaaaatc tctctgctat ttttgttcta 34801 tcctggctcc agctgattag atggtgcctg cccacattga gggcaaatct tccccactta 34861 gtccactcac actcacatgc caatatcctc tgtaaacaca ctcacagaaa caccaaaaaa 34921 taatgcttca cctgttctct agttattcct taatccagac aagttgacac ctaaaactaa 34981 tcatcacacc atgggaccta gcaattccac ttctgggcac aaaagaactg aaagccggga 35041 ctcaaagaga tacttgtata cccatgttca tagcagtatg attcacaatg gccaaaaggt 35101 gaaagcaacc caagtgtcca ttaacagatg aataaacaaa atgtgtattt atatataata 35161 tatatacaat aaaatattca gtcttaaaaa ctaaagaaat tctgacacat ggataacata 35221 gatgaacctt aaagacatta tgctaagtga aataagtcaa ccacagaggg acaaatattg 35281 tatgattcta cttacatgat gtacctagag tagtcaaatt catagagaca gaaagtagaa 35341 cagtggttgt taggggctac gaggagggga tgggcagtta gcatttaatg ggtatgaagt 35401 ttcattttgg gaaaataaaa aaattctgga gatgaatggt ggagactggc gcacaacaat 35461 atgaatgtac ttaatgaccc tgaactgtac acttaaaaat ggctaaaatg gtaaatttta 35521 agttatttat attttactac aaaaaaaagg taacatacta aaatgatctc atgggttttg 35581 tgagaatcaa atgagatcca tgtagagaag ccttgtagtc tatatagccc ttcgcaaatg 35641 ttagctcttc ttagtcatta tcactccatt ttccccaatc tgataccatt atccacacac 35701 tttacccagc cacacttacc caacagcaca ctgtttgagt ttgagtgcta tctggtgaat 35761 actcatcttc attttgctaa accctggatg ccatgtgcta gccaacaata tcctattgtt 35821 ctggttctta aacaaaacaa aatctcaaag acttcttcct cttacctagt tttacccaat 35881 gattggcttt gaagcagtcc ttattcagta ataagaggtc accatgccat ggccaagaat 35941 agggcaaatc ttcctccaat tcagttgaac tccctggccg tctagcaaac aacatatctc 36001 ataacacatc ctttgagcag gtgaacaact ctgaaccttc tttgaaggaa caggattctg 36061 ggaaaggaat aaaagaaatg catgcagtgt gtattgagaa taaaatctat tagctaagaa 36121 ataaaaaatg aaaatgctac aacatgatca gttttgatgg actagacaac tctctgtaga 36181 gtagccacag ggctgaaccc tcaaatattc ccagaaagta tagacattgc tgtagaacca 36241 gcctgataat gcagcagtgc agaacttaag aatgatattt ctttctagaa agcagaccaa 36301 ttgatatctt catcctgtta ttgatcagaa tccacgtcag cattcaggtg ctctctggct 36361 acaagtttcc ttagctcttg caggcgctgc tcattgaaga tttctcttaa cacaggtaat 36421 gctaccagtc tcatctggca cctttttcat gcaatgacaa ctatccagga gttgctgcct 36481 ttccagatat cccctgcgag accaatgagg gattttattc catgactctt tgaagaggtt 36541 caaacatgga tcaaacatga agtagtatgt accccagcct tagaaattta atcttttatg 36601 actgggagaa agaacccaag tctctgtgcc ttcacagtct tgaatatctc tgcttgtttc 36661 acttacgttt acctcactca agattcttag tgtcatcgac atgactggtt aagaactcag 36721 gacttttcaa caaagttttc tgccagtgcc ccacaaatca tgactgtggt ctcccaaatt 36781 ctttgattct ccactaggtt ccctttctcc tccattcaaa gccccaaata acatttaccc 36841 tatatattta gtcccgtttt ttgtagaaat gcttctttgc ttgtgttccc cctacctttt 36901 catatcatac ctacatcgtt aactgaggct cagtcataac atcaacaaca gcatgaaaca 36961 tcccaccttc tgtcttcatt ttgctataaa ctggaggcaa aggaaatgct gtcactcagg 37021 gagtatatca atgaagggaa agactctcac aagacaggca ctgaggcagg agtcactagc 37081 acacagtgta taagtgaaat ctaaatataa aaaagcaagc acttgggata catcccttgc 37141 acacacctcc tcttttataa ccagtagagt gaagttggtt gctgaagtca cagaatcaat 37201 agtctatttc ccacagacgg ctgatgatag cagaacaagc cctggctaag tcccccaccc 37261 ttttcttgag tagctcattg ttatgagcca cggacccacc atcaccaggt cacatgttct 37321 gtactctttc ctaaaaacag tgacaaaata tgctgagcca tccatatttc ctcagttaca 37381 ttgagaggca ggagatataa caattaagca gtctctggag ccagagcaac ctgagctcaa 37441 accatgcctt agcttgcttg ttgtgggacc taggcaaagt tactgaaact tctttagaca 37501 tgtttatcaa taaaatgggt acagttgact ggctccaaga tttcttgacc tcttgatgta 37561 tttgccctgc ataattccta agactgtgat tataatggat tttactctta tgattaggtt 37621 ttcacatagc acagttgact ttaatacagg gagattatct gggtaggcct tgcctaaaca 37681 caagagccat ttaaaagcag agttctcccc agctggtcaa aagagagaat ctctggtcag 37741 agattcacag cataagaagg tttcaatgtg ccatcactgg ctctgagatg tagaaaccca 37801 catgtaagga ccaaaaagaa gcccttagga gctaagagct acagccctcc agccaatagc 37861 cagcaaagaa acaaggacct cggtcctaca accacagcca accaaattct gccaacaaga 37921 aaaatgagct tggaagctga ttcttctccc aaagattcca gataagagta caacaccttg WO 00/09525 PCT/US99/17712 EPI-109 912 37981 atttcagcct tgtgagatcc taagcaaaga acccactcat gtccacccaa acttctgacc 38041 tacagaactg tgagctaaca aatgagtgtt gtacatagtgg attctgta 38101 cacagcaata gaaaactaat acaatgagga cacagcaagt gcttaataaa tgttagcttt 38161 tattattact aactcattgg gatcagctac acagttgtaa gaaggctaaa gtaaaaatta 38221 tttatgcaag gctggcagtg caacatagca ttcagatcca gggtccattt ggtctaatat 38281 ggctgatatt aagtgtttct caaggggaga gacattattg gcattcagtg gggggagggg 38341 ttcatcctgt agaactgcct tggacatggc agtccattta tcatctctgg cttctcttcc 38401 cctagcagta gtcattgcaa caactgaaaa tgccactgta catttccaaa aatgctcctc 38461 cacaagggtt gagaactttg agaactactt taagggaaat ttcataagaa agcatgcgtg 38521 tcttaaatgc tgccataaag ctacctcaat aactacaatg ctactcaaat tacctgaccc 38581 taagaatcgc cagtggcact tgtttaaata taacgattcc caagttcttt ccctggagtc 38641 ccattccata gggctggggt ggagccccag gaatctatac tcttactcaa agaccccagg 38701 ttaatctttt gtttatgtaa gtttgccaaa cactgagtta gaaatatact cagccgtaca 38761 tgcatttagc aaaattcac cacaacggaa caatgacaca ccaaaactct ttgaaactgt 38821 gccttctaca gagctgtaaa tctccttttg gaccattcca ttacacaagg tgtcctcttg 38881 gtcacacagt gattcaaat gggactctag agtcatggaa atgggtatac tcttctcaaa 38941 ctttccatct ttaccagaat tacttcttaa agtgatatgc ttcatggtgt aaactagcac 39001 ttattaattt tttctaaata tttatcatat ttcatatact tttattttgg agatggagtt 39061 tcgctcttgt tgcccaggct ggagcgcaat ggcagatctc ggatcaccgc aacatccatc 39121 tcccgggttc aagcgattct ctggcctcag cctcctgagc agctgggatt acaggcatgc 39181 gccaccacgc ccggctaatt ttgtattttt agtagaaaag gggttctcca tgttggccag 39241 gctggtctcc aactcccgac ctcaggtgat gcgcccgcct cggcctccca aagtgttggc 39301 attacaggca tgagccaccg cgcccggccc atatactttt aatacatgtg gaattaataa 39361 aaacgtccat gcctccaatt ccgtggctat tttaccgtct tcctttttcg gacaagtccc 39421 tcaaaggtag cgctcttggc tccttccttt gcttatcccc taaccctgtc ctcctgaggt 39481 gccccctgga tttcctccaa ccccggcagg gtctgccttt ccgggatgat acaacgacct 39541 gccctgcatg ccatatccca ggcgcgtggg caccaaagtg tggaaaaacc gatgaatgac 39601 gttttctgtt tccgatactc tgcctgccag aatcccctgc cgcaccgccc caccacgaag 39661 cacatggaac ccacggacta cacgaggaca gaggtctgtt ctccctttac ctctcccatt 39721 tctttaacta tgcttctctc ggctggcatg ccctttcctc atctcactcc acacacgaac 39781 aggtttagca aataatatgc acgctgctgg gacgggccca agcatttccc tcccttgata 39841 gggcggaact aaaatgcaag ccccacagtt gtcagcaaag gacttccctg ttaccatggt 39901 aaagccgctg cgcctttatt gtggttgagg agtacttgca tcaacctaag agaaaattaa 39961 taagaaggaa gtctgcaggc tgaaaccctt caaattagcc tggactcgcc tgcatctggc 40021 tcggaacaga gttaatctca ggagtgagaa tatagccctc cggtggacgc aactcgcgcc 40081 tgcggctaac agaatgtctc caggggaggg gctctgcgtc cgttccgccc aggcccttcc 40141 ggctcacgcg ccgtacggaa gcgtgctcag cgctgggctt gtgctccgta cggaagtgtg 40201 ctttggcgca ccggaagccg actcaacaga gctatggcgg gtttgactgt gagagaccca 40261 gcggtggatc gttctctacg ttctgtgttc ggtgagagga attcgttgta gtcaagcttc 40321 ggggagggac tcccctctgc accttctatc tcatgaatcg ctaccggagc cgctgacggt 40381 tcggacgtgc agttctccct gcttatcctg tagggcgtcc aacctggtgg actcatgagc 40441 aaagagatat tcccattctg ccgaggtctc gtaggctttc cgcaatatca gtggggaagt 40501 tagactagcg ttcagcttct gtgcgtttct cctttcatga gcttcaatta ttctctagag 40561 gagaaggctc acggtaacag ctcctcactg tcccgtacta cttctcatcc tctgccccag 40621 aatacagact atatgctgag ggtataqatc ctagtgtcca cttactgtcc tctcctaagg 40681 actttcatcc tttgcttttt atctgtaaca ttttagtgca tcaatagtgg tagcggccac 40741 ctggtgtcct gagatggctt gtaagtgaat gaatgaatga actattaaga tctcctcaga 40801 ggaattttaa aaaggatcga aacgattctg aattatcttt ttggctgaaa taagttgttt 40861 ttaaaaatac gtgtgattat tttagagtac catttgaaag ggacatgaca aagtagttca 40921 gaatactttt taaacatctt tcactacatt catcgtcatt ctcccttaaa tgttgtatgt 40981 gtggaaatac ataggaacct gttttaaaaa ttatattaaa taacattgat attttttgta 41041 gtcactgatg agacttgcag atctttaggt aaataccagt gccaaagtat ttatttgcac 41101 caaagttaag gaaaatctaa cacgtgtcag atcagtctga gaactaacat ttgagagtac 41161 ctacacattt tgtatttagt ttcagtggta tatttccttt gttaagaggt ctgaagaaat 41221 acaatggaat tgggattgga gaacactatt ttgagtctta tatttgatga tataagttta 41281 ctttctcact aaagatctat gttataaact cagaatttta atgttaccta ttttcttcct 41341 tagtggggaa cattccttat gaagctactg aagagcagtt gaaggacatc ttttctgagg 41401 ttggacctgt tgttagtttc aggtgagatc cccttttcct tcatggtggg agcttcttaa 41461 aaatcaccac agatttggct cttagtaata atggcaggtt ttctttactg gtgacttttc 41521 acatacattt tgttcttgta acagctttat tgagatataa ttgatacact atacaattga 41581 catttattct tacctaaaat atgttttttt cgttaaaaat gttttttagg cagggcatag 41641 tgactcaagc ctgtaatccc agcactttgg gaggccgagg caggcggatc acctggggtc 41701 aggagttcga gaccagcctg accaatgtgg tgaaaccttg tctctactaa aaatacaaaa 41761 attagccgcc gtggtggccc atgcctgtag tcccagctac tcaggaggct gagacaggag 41821 aattgcttga acccgggagg cagagatagc agtgagccaa gatcatgcca ctgcactcca 41881 gcctgggcaa cagagcaaga ctccatctca ggaaaaaaaa aaaaaaagtt ttaaaaaata 41941 tttctgtgag gctgtcagag atataaggtt atttatgtta cagtgggccc aattaaagca 42001 tggcaatgtt agcaggaacc ctgtatgtgt gtaacatttg ttcctgacac ttggttctgc 42061 tctccagatt ggtatacgat agagagacag gaaagccaaa gggttatggc ttctgtgaat 42121 accaagacca agagacagca cttagtgcca tgcggaacct gaatgggcgc gaattcagtg 42181 ggagagcact tcgagtggac aatgctgcca gtgaaaagaa caaagaagag ctgaagagtg 42241 agtacaaatc caacttggat gcagtatgag ttagtaaaga tgtaacaatg aagattttcc 42301 atttctgata tgttttagaa tatgctgaaa tggttagcca cgcagcttgt ttattacttg 42361 actgacctga tgtgcctgag ttaggcaagt attatatata tctttttaaa aactttttat 42421 aaattttttt tcaagtaatt gtctgaaatt tctataccct tgctctggat ggagcagggc WO 00/09525 PCT/US99/17712 EPI-109 913 42481 aaggcctcaa accgtttcaa aactgttctg gcaagcactg tagggatgca tagggtcact 42541 gcagacctaa gcatgctgga ggcttgctag taagtgtata tctttaagaa acagataaag 42601 ttgacattag aaattctt a gttgctccag cctgggcgac agagtgagac tctgtctcaa 42661 aaaaaaaaaa aaaaaaaaga atttccattg ctaaggagtt atttccagtt aaagatgaa 42721 tcaaattcat caagccatta gtagtactaa ctgtggcatt agtcattcct gtcactcttt 42781 tcaggaattt ttgaagttag cgtatttttc tcttttaacc ttttgtttct gaaatgacttt 42841 gttaaaagaa gtcaatgtgc ctagttctct aacttaggtt aacattgtcc ttccatgtga 42901 tcatgatccc cagctttcct ctgagaacag aaaatacact ctcactttcc tccacagaaa 42961 caagaggctt tcacatcatt tatttctcag ctctggagaa tctaaaatta tcagctggtt 43021 cttacagcag ccctgaaaag tagatatttg aaatgattta gctttttgtt ttgcctccct 43081 aactttcttg tactttctc ttgattaggc cttggcactg gtgcccctgt cattgagtca 43141 ccttatggag agaccatcag tcctgaggat gcccctgagt ccattagcaa agcagttgcc 43201 agccttccac cagagcagat gtttgagctg atgaaacaaa tgaaggtggg aggaggcatt 43261 aggttatgaa taaagcaaat cacatcaggt tttcaaggag ttacttgaat tagttccctg 43321 agctcaaata gaaattgtct gtagaccacc atttcttgca ccttcaatat tctgtatgta 43381 cacagtatat tttacatttt gtacaaagag ctttctattt ttgtacacaa acacagctat 43441 ccaaacaatc cagctggagt tttgtggccc atagatgtca gatgtagata ttaaaatttg 43501 gcttttttcc taaatgataa tatcacagta tttgaaatgc ctctttcttc tcttgcctgc 43561 catgaccaag gtttttttgt gccatgcaaa aactaatgat aaagagcctc ttgaatatta 43621 catttctcag aggggaatgg ctctaaatca ctatcagttt ctaagtcata agtattaaac 43681 ctgaatctgc ttatcttctc agctctgtgt ccagaatagt ccccaggagg cacggaacat 43741 gttacttcag aaccctcaac tggcttatgc tttgctgcaa gcacaggtag tgatgagaat 43801 tgtggatccg gaaattgccc tggtgagtgc ttctggttct tttatggaaa tggtcgggta 43861 aaccttgaat gggataggaa ctacctgatt qctttgttaa acagacagct cataggtttg 43921 tcttttcact ttttagaaaa ttctgcatcg ccagacaaat atcccaacgc tgattgcagg 43981 caaccctcag ccagtccatg gtgctgggcc tggctcagga tccaatgtgt caatgaacca 44041 gcagaatcct caggcccctc aggcccagtc tttggtaggg ctttatccct taacattttt 44101 ttgtatctgt cttagaatgt cattttcttt ttaggagaat atattgaaag aagaatggtc 44161 aggaaccaga gatgataatt tcaatttcca ggcataaaag caatttccag gttgcagagc 44221 acatgacatc tgaatgaata tagattcgat tccaagtttg taaaacaaag agatccttcc 44281 cgtatgccct tttcttataa gctaactttg tgtgtatgtg catgcctggc actgtggttg 44341 gcacttcgtt attccatatg cattatctca tttaatcctc aaagcaattg tatgaggttg 44401 gcactcttat tatctccatt cttactgatg aaaaaagtaa agcttgcttt caaagcatga 44461 cacaaaacct taaagccata aaaaattgat acatttgaaa actaaaaaat ttctatataa 44521 agaaaaaaat aagtatcaaa gacatgacaa attgagaaaa agtatttacc acacatgtga 44581 tggaaaacag actaataaag agcccatagt cattcacaag aatgtttatt gccttagagt 44641 gaaaaattgg aaatgtccta aatgtacgtc agtggaagaa tggagaaaat gtgtggtaca 44701 ttcatccagt gaaatactgt acaacagtta aataaactac acgtatcaac atgaatgact 44761 ttgaaaaaca taattccata cagcagttaa gatgaactag gatacataat atcaacacaa 44821 ctccaaaaca gtgacatacg gacatgaaac taagtgaata tggatgcatt cccqaaatgt 44881 aggatatatg tttctgcata aatccccaaa atatgtggaa tgagttgcaa aataatatat 44941 tgagtatgta atgattcata taaaattttg aaacattaag aagacgtctt agtggtcatc 45001 aaaggagaag agagcacagg atgcaattgg ggaagaccgt acaggccatt ggtttatttc 45061 atttacttat ttatttccta agctgggtgg ctattttatt ttctatatga tttgtatatc 45121 tgtaattttt cataataaat tttaaaaggc ctcctataaa ttagtaagaa aatttccaat 45181 aacccagtag aaaaatggga aatagacata aatatttcac aaaaggagaa atataaatat 45241 ataaaaattt attcaacttc aaaataagat aatgtaataa attatcattt atatatgtaa 45301 tgttataaga taatgtaaat agaaactaca ataagctacc atttttcatc tctcaggttg 45361 gcagaggtac agggcaggga ccagcaaaca tttttctgta aatgatcaga cagtaaatat 45421 ttttggcttt gcaagtcaca ggatctgcca cagctactct gccatggtag tatgaaatca 45481 gccataggca ataagtgaac aagtgtgtgt ggttgtgttc cgttaaaagt ttgtttataa 45541 aaccaggcag tgagcccgat ttggcccatg ggtcatagtt tgccaacccc tgctctaaat 45601 aaataaatac attttcagag atagaaaaaa aaagctaagg cccagagagg ttagctggtc 45661 caaaaattga cacaattata agtggcagat ctatttctga acctggtttt atctgacctc 45721 acagccagtt ttctcttaac tactttccta tacagctctt ccttttcttt tgtagagttt 45781 -tgtgttcctt aaacgtatat gtgatttttt ttacagtct tgcctttcttt tgttaattta 45841 ttgagctgtt tctaattcaa gggactactc agttttttgg ggaatgcaca gatgaaaaga 45901 tgacattctc tttttctcaa cgagttttaa tgtagcattt aaaaaaatat atttcacatt 45961 cccccaaaac cagaattata tctaaggaca ggagtgagaa aagattggtt aaattaaaaa 46021 aaaaatttaa ttttaaaaat gtggactacc agcagttgtt ttttttaaaa gagtcccagt 46081 ctccttttat gtttcttggg tttagggctt tttttttttt ttttttttac tcttattggc 46141 agccccaatc atgaagttaa cagtaggtgt tatgtgctgc cttgccacac agataagact 46201 tgtcaatctc tacattgaga atatgttcca tcttaaccgt gttccatata accaggctca 46261 tgacgtatat tgcttctgtg gagtttaaag tgtgtgacaa atctaatgct gcataagaca 46321 tgccatacaa aaaggatgtt tagtagtgta tttggggctg ttcatttgaa gaggactttt 46381 aaggtcgtag acttagtata ttgagtatcc acagaggcat atacatactc tgtttttttt 46441 gcttggtcag ggtggaatgc atgtcaatgg cgcacctcct ctgatgcaag cttctatgca 46501 gggtggagtt ccagcaccag ggcaaatgcc agctgctgtc acaggacctg gccctggttc 46561 cttagctcct ggaggtaagt ttcatttagt cttcaccatt tcagtacttg ctaaagtttt 46621 gtcatagcca ctgttgcagt gcagccaaat atgataatgg gatccttagg taaaattaat 46681 acacagctag aaagtatata tcttaggtgg aggaaatagt agatttctta cgttaaatc 46741 tgtatgtcta attataagaa cagggaaagg gacagtaaag tgaaagagca tagtaaaacc 46801 tccaagttaa caagggggaa aatggaatga gtggaaacaa aatcaagcca gcaaaaatag 46861 agaagaggaa aaaagtaaga gacagtgtaa aataagtaat aataaatgta gagtaagatg 46921 gaaggaataa aaactaatgt agttgttact ctgctaaata tgaatgaact gtcagattag WO 00/09525 PCT/US99/17712 EPI-109 46981 gttcaaaac tcatgaaaa aacagacaaa aaaatacaag gtcacatttg ttatagcata 47041 ttaaactgac ataaaattgt attttaacaa acataatcag aacaaacaac aaaagggaaa 47101 aagagaaatt taaaagctat gtacatttat tgaaaatgta tagatcggca attaataaga 47161 gtattgctca tatacttgta actgttcctt gttcaacaat tgtaacaag aagattgagt 47221 gaaataatga ttccccatat aaacatctg tatgaacaca tgatgtatta ccaatattta 47281 aagttttttt atgtaacaaa cttggttttt gttaatttat ctaatctagg gtaggttgag 47341 tacaacacta ctcatggaga atgatttaat tctaaattgt tctgttctgt agagaatcca 47401 gtctgcagag ctaagttgat gaggaatgga agaagagatt ttttgaagaa atttctgcaa 47461 actcaggaat tttttgtatc tactttagga ttgttatgta tctacttat cctaatagag 47521 ttatacttgt atttaaatta tctttcatga caggaggtcc atgggtaagt gacattgttt 47581 tcctgtatta tagaagagct tcctgccaag agtttggtaa ccaatgaaat gaattattct 47641 tattgaactc actattctgt cactgaaaca taaagtacaa attgtaaata tactaacaaa 47701 ccccatcttc tctctcattg cattgttgaa tatcttcctt tgtaggtttc tgcttgtgga 47761 gcagaatgag gaaatttgta aactcagcca ctgttctaat ttttcttttc cgctgttcta 47821 attggtgttt tttcttgtct gccctttatc ttctaggagg aatgcaggct caggttggaa 47881 tgccaggaag tggaccagtg tccatggaac gggggcaagg taaataaata ttaatgtctg 47941 actaatgtta attggtcatg gaagtgttcc acatccacag tatctaatat ggcagccact 48001 aaccacccat ggctatttca atattaagtt aattaaaatt aagtaaaatt taaaactcag 48061 ttcctcagtc acaatagcca cattccaagt gctcagtggc cacaggtgac tagtggatac 48121 catacaggac attacagata tagaacattt ctatcatcgt aaaaagatct attggacagt 48181 gctggtctag actttccacc tggtgattca gagtccagct ctacaagaat tgataatgaa 48241 gcaagtggat cgtttgtttc ctgattccta gtctaataat tccactgaca tgttctctct 48301 ccctgtatgg atatctgttg actgagtaag gaattttaat aatgagcatg taaatatgtg 48361 gctgggtatg tagaagacta gatttaaacc ccagagaaaa ctgggaggga atcataggtc 48421 tgtaacgcct acttaatgaa catatgttgt accgtggctg tactgctata tacaacagta 48481 gctgctgctc caaaatctcc atgttgtttc ttcatgttac tggagtttga aggacaagaa 48541 agtgcagtgg ttcagttgga aacaatgtta ggaggagaga tcgtaagaaa agagaaggaa 48601 ctgagtgcat actatatgcc aggcacttta attttcataa ataatcttgt gagttaggtg 48661 gcagcacctc agttttaca gcaaagagtt ggaagctcag aataagttac tttctcaagg 48721 ggacaaggta agtaaatatt aatgtatgag taatgtggac tggatttggt gctcttattt 48781 tctcttccaa ctagtaagtg gcagagctaa gattcagaag tctttgactc cagaatctgt 48841 cctctttctg tcactccaca ctgcctctgt taacttccaa gcatattctt cagtgtcttc 48901 tactcttatt ccttgggaat aaaatgatgg gaaagactgc tttggacaag catagagaag 48961 cttaaggttt tttcttttgt agcatatggt ttataagtgg aacccattta aaaagcaaaa 49021 tattggccag gcgcagtggc tcatgcctgt aatcccagca ctttgggagg ctgaggtggg 49081 tggattgctt gagctcagag gtttgaaact agcctagaca acatggcaaa accccgtctc 49141 tataaaaaat acaaaaacta gttgggcaat ggtggtgtgc acttgtggtc ccagctactt 49201 gggaggccga agtggaagga tcacttgagc ccaacaggtt gagactgcag tgagccataa 49261 tcgggcacca ctgcactcca gcctgggcaa cagagcaaga ccctgtctca aagaatatat 49321 atatatacac acacacacac atatatatac acacatacat acataaacat taatatacaa 49381 gcctgtggtt tttacactgg ggttggttgc tgaagtgaca gaattaactt tttcttgtta 49441 gaagtctgac agcaggacaa actccctggc caaatatctc atattttctc taagcatcca 49501 atgcttttgt gctattgtac atccctctat ccccaccgca ccactgtcaa tagatcatat 49561 atgttcccca gagtatttct gcagtaatga gaaggtatta gggtttcagt catacttctg 49621 cctgtcatgg ggccagccct caatccatca ggttttagct gtttaacgca tacttgcaca 49681 agacatcttc ctattatagt tatcttcacc tttttgtcag aaattggcaa agggaagtga 49741 ctcatgtttt gagggtattt ccaggatgtc ttcatgcaga gactaagtga gatgagcttt 49801 cttttatagt ttccttcagt acccagcaga ggaagcaaga gtcttttcgt gtgtgcctag 49861 tttgtcttac ttttcctgaa atccatgctg cttttaatgc tgaaagaga tggagatgtt 49921 tgagaagata cttcttgctt ccctgccatg tttgtttagt gtcggttccc atgtcatctc 49981 attagtcttt gtttgctgtt gtcatgatgt ttattatcaa agacttgctg tggcagagta 50041 tttcttgtgg agtgatattc tctttcatca tgtaaagttc attcactgca tttccccatc 50101 tgatacattt ttgacagcag aaatttttgt gctttaaaat gtgacaaaaa tagaattgcc 50161 gtacttcagt tatggccgtt tcagaatgaa tcttgccttc cagattcagt gcagtttctt 50221 ttatgttttg cttctgaaac tacatttatg ttctttgcat aactagaaga ttcaaaacta 50281 tcctttttat atattttttt cctaatgatt tcataaggag acctaacgga aaactagtag 50341 cagaggtgaa aatcgaaaat gtcaggttat tcccacctag atcaaaccag tgcccccatg 50401 ggattccctt tcaaaagcta tctggtcaaa atggaactat ttcagagacc caaaggagct 50461 agtgtagttt agggagattt tgtagcctgg agcaagccga tgaactcttg gctttttaac 50521 ttatatatgt aaatctcaat ctccatgtgt gtgtgtttct gcgtgtgtat gcaagctatt 50581 ttaagtgtct gctctttctc cttttgaact tactgcttac ctaggaaccc tacagcactc 50641 gcccgtggga cccgccgggc ctgcatcaat tgagcgagtt caaggtaccc attgtatctg 50701 tgggtttcct tttgcttgtg gtgttcaggg tgggacgttg agaggaaaag agctgcgtgg 50761 cagtcatcct cgcgttcaga acccaaaagg gtagtgtttt tgggtttttg tttttttaat 50821. tttttcctgt tgaggccaca agcctaagat tgacctcttc acacagggca gagaacatgg 50881 atgatatggg catctgtccg aggctgtact ccctccctac tggtgtcagg aggcttggat 50941 ggaatagcag tctgtaagga gacagcgggt tcttgcagag ccatggcagt gttcacatat 51001 gccaagactc tacctctgtt ttgtgactct ggtccttgaa ctaagattga ttagaaggaa 51061 aaccaggagc ataagtttct ccaggtcgca gtgctagccc ttggcaggtt gctccccagt 51121 ttgctcttta tataattcca tccatacctc tgacatggca cagattctgc ctacaccctg 51181 cttctgttct tgagctgcaa gaggattctg ctgtggtgag gtttcaccca ctctaaggtg 51241 tctgaattat gttgtcagtg gtatatagag tcatttcttg tttgcttatg tgtctttcac 51301 agcagtaact ccccgtttgt ttccctgtca gtgccgatgc aagaccccag agcagctatg 51361 cagcggggat ccttgcctgc gaatgtccca acccctcgag gcttgttagg agatgctccg 51421 aatgatccac ggggaggcac tttactttct gtaactggag aggtagagcc taggtaagca WO 00/09525 PCT/US99/17712 EPI-109 915 51481 ctaacataga aggaaacagt tgaagaaatc agaattgtcc cttcttccct gagaacaaaa 51541 tctttctgta ccagttgtac ctgtttgcct acttcaaaag gtagatcaat attcatggcc 51601 actgtccaag ggtaagcact tctcctaagg cagaactatg tacttgagta tgtcattttg 51661 agctattata tttttagaaa ttggaaattt tagtatacat acttgaacag ggaaatttat 51721 agtagtggaa atattaataa tagcaataat aggccgggtg cagtggctga cgcctataat 51781 cccagtactt tgggaggcca aggtgggtgg atcacttgag gtcaggagtt cgagacctgc 51841 ctggcctaca tggtgaaatc ccatctctac taaaaataga aaaattagcc gggcgtggtg 51901 gcgggcgcct ataattacag ctactgggga ggctgaggca ggagaatcgc ttgaacccag 51961 gaggtggagg ttgcagtgag ccgaggtcat gccactgcac tccagcctgg gcaacaagag 52021 tgaaactcca tttcaaaagt aaataaataa ataaaataat gatagtaata ataattgaca 52081 ttaatgggga tcatgcctct gactctgctc tgagtacttt acttagatca tcttattaaa 52141 tccacaagat cctgtgagat ggataccatt attagtccca ttttacacgt gaaactgatg 52201 tgtggaaaag ttaaataatg tgtccaatat cacacagcta ataagtgata gagcctagat 52261 ttgaacccat acagtctgaa tccagagctc atgttcttat gcattgttct gcaaactcat 52321 acatataatg aatattcgtt gattcctccc taattatgaa ccaaataacg aaattctaga 52381 atacatggat ttatatctct gtagcttttc ttccatctat ttggtgttat tttcttgtta 52441 gtattcatag actacatcag ctctttgttg gatgtttact tactgatctg gttggtactt 52501 tgttgttgtt ttgttctatt ttaaaataca acgtttttct ccatctccag aggttacttg 52561 ggaccacctc atcagggtcc acccatgcac catgtccctg gccatgagag ccgaggacca 52621 cccccacatg aactgagggg agggccatta cccgagccca gacctctaat ggcagaacca 52681 agaggaccca tgctagatca gaggggtcca cccttggatg gcagaggtaa ggggagatca 52741 cattgcaaat gccataatga actcaactgt cttaggctct aatctgggat aaagaatgct 52801 ggaacagtag gtttgcaagc atctttaagg tttatccaca aatctgagaa actggggagg 52861 agacaatagt ctcatatgtt aatagctgag gggacaaatg tgactagaag agatttctat 52921 ctttcttgga ttgttcatca ttcttgcagt acatgcaagt agctacataa tggttttgtt 52981 acatttttct ttataggtgg aagggatccc cgaggaatag atgcacgagg gatggaggcc 53041 cgagccatgg aggcaagagg gttagatgcc agaggattag aggcccgtgc aatggaggcc 53101 cgtgcgatgg aagctcgtgc aatggaggcc cgagcgatgg aggcccgtgc aatggaagtc 53161 cgagggatgg aggccagagg catggatacc agaggcccag tgcctggccc cagaggacct 53221 atacctagtg gaatgcaggg tcccagtcca attaacatgg gggcggttgt cccccaggga 53281 tccagacagg tatgtgtaac actgacttct ggcatccaag tgaaatcttg atctattcag 53341 gaattgatta ttgagcctaa ttattactgc cttctgactt gggctgtttc ttagcttgtt 53401 agaaagggaa gacttggatc tccctgtagc ttctctgtcc cttagggtgg tgattttctg 53461 gctatcagga ttgtagttca aaaaaaaaca accttatccc acaataaata gctattcatt 53521 tggagcagag cccctgaaaa tttaggggtt agaaagtagt cttgattggg gtacaaacca 53581 acatcatgta cacggttttt tccaagatat acttgcccgg atctcatccg aggtataact 53641 cagaatctct tattagtagg atctgagcat ggatagtttg aaaaacttcc cccaaatgat 53701 tctaatgtga accctgactg ggaaccactg ggttagagta tatgaagagc tgttagtggc 53761 catttagata atcttaggtt tagagagacc tgtgttaatt tattgtcatc acatagccta 53821 agtgaacagt ggaatgtgaa aggcagttta ttaataatca ccttaaaagg tgtggaaccg 53881 aagtcttgtc tcctctcttt tatttggatc tctctgcctg tgtgtacatg ctccctcttc 53941 atctcgactt ggttgtggag aggtggtatg tgtgtttctt ccgtgagttt ttatatgctg 54001 gcaccttcat ttccctctaa ctgctccacc ttccttttcc ccccttcctc tgcgtacttc 54061 tctcttcttt ttttatgtgt cttcctcccc atgtctgtgt gtatgagaga gagaaagata 54121 atggcagagc tggaatggaa tacatcaatc atctaattcc ctcagtttat agatttggaa 54181 attaaggccc aagaattcag gtgacttgac caaattcaca tgactaaaaa gtggcagagc 54241 aaggaacaga agccactact ttttccactt tactactctg tcctgttatc tgcacatttg 54301 tgtgtgtgta tatgtgtgga tatgtgtcta ccccctcctc tgtaatatga aatacaaata 54361 gagggttttt ttgctatgtg tagaataaaa ctgttctcta ttgtgtttga agtgtttgtg 54421 ggccttgatt tttattgtac tctctatggt cagtagccta gtaacagaaa tggtttttat 54481 gcattcattc tgtcactcag caaatattta ttgagcacct actatgtacc aaacatagat 54541 ctaggtacgg gggatactgc agtgtgaaca gaacaaagcc ccttccccca tgggcttaca 54601 ttctagttgg gaagacagat aacaaacaaa taactacata atgcgcttac ataattttac 54661 tggtagttct atgatgcaag acattgcaag taagggttgg aagaacattt ctggataata 54721 ttttgctcct ttctctctgc tggtacttga acttattacc ctaatactag gtttatacca 54781 tttttattag tagattcgat aaagccaatt agatctgagg caagagaaaa tacaaatttt 54841 atcttcaaac ctttaaaaaa attttaaatt aatatattaa cttataaata tatatattcg 54901 ttcatctata aaagatatat gtattaagaa cttcaagcca ggcatggtga catgcacctg 54961 tagtgccagc actctggagg ctggggcagg aagaccattt aagtctagga acttgaggct 55021 gtggtgcatt ctgatcgcac ctgtgactag ccactgcact ccagcctggg cagcatatta 55081 gactcccatc tttaaaaaaa aaaaaaaagc cagggtagaa tcctgtagtc ccagctactc 55141 tggaggctaa ggcaggagga tcagtagagc ccaggagttg gaggcccgcc tacacaagat 55201 agtgagacca catcttaaac taaaaggaac cttgcttcct ctcctatgct tgtctcccct 55261 gtggccctct aggtcctgta gataatcact tttattagat ttttcatgtt actttctgga 55321 aaacatgaat atatattatt tttccccttt cactgttcta tacctttttt ttttttaact 55381 taacaacatg tccttaattc atacttttaa attagatttt aaaattaact ctagtccact 55441 tagttagaaa cttgtgggca aaaggcttat tattactagg gtgattatat aatttatcat 55501 ctaaaggaga acatgaaaga aagtgctgtt actttacttg gaggcaaaaa cataaactgg 55561 gactatctta gggaaaccaa gatgtatggt cacttttgct agtacttgtc tgcctagaac 55621 aagcacacct agaaacttaa aatggccgtt attgagtggt tagatcacaa ttacagtacc 55681 tcagattaaa gcttcaaaaa gattatactc aattccgaat tgtgctgcta taaactcatg 55741 tgaccaaaca ccacctgttc cccaataacc tatggaaata aaaaatttta aaaaaaaaga 55801 ttatactcat aggtgtttca gacccataat agctcgttaa tgttcagact ggtctctgga 55861 aacttgtctc tggtttcagt attgataatg aacagaacag tgataatatt ctagcagtct 55921 atacaaatct gtactaatgt ttcatctatc cattgtcttt gggaaatgag ttaatgcatg WO 00/09525 PCT/US99/17712 EPI-109 916 55981 taagtgaatg ttccagataa tagaactatt ctaccaagtt ttttaacttt tttaataaaa 56041 aattataaaa agtatttgat atttcctttc ttgaacagga tacaaaaaaa tagtttaatc 56101 agttttgact actcaaggtc atcattgaat agattcatta ttgtctatac cgtaatataa 56161 aacatagtta tctcctgttt ggtttctggt ctccttcact gtcaggccgt cacctggctc 56221 ttcatattac tgaagtggta tctgctccta acagttattt atccgtattt cttttatgtt 56281 ttgctgcttc taatctgctg ggtaagcagg taacaagttt gttaacaata tgtgtttatt 56341 aagagagtac ctaagctctg ggtgaatgcc tgagtgtgaa cataatgctt gtatagggac 56401 attctaacag ttagatttgg tactcaagag gtcttttcct tggttctgg tagtcttgca 56461 aagggttgaa ctcattgaag atcttaagta ccagtaagta tgatatcact gtacttggtt 56521 ttttcactcc agtcagtcat attttttggt ctacatttag cagaaagcat ctgccatatg 56581 ttc (2) INFORMATION FOR SEQ ID NO:2693: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: _base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2693 1 ttcagttcta gcgtcaaccc ggtgctctac gtcttcaccg ctggagatct gctgccccgg 61 gcaggtcccc gtttcctcac gcggctcttc gaaggctctg gggaggcccg agggggcggc 121 cgctctaggg aagggaccat ggagctccga actacccctc agctgaaagt ggtggggcag 181 ggccgcggca atggagaccc ggggggtggg atggagaagg acggtccgga atgggacctt 241 tgacagcaga ccctacaacc tgctgccctt ccctgtccct ttccaccccc cacccaccct 301 ccagaggtcc tcccgacggc catgaacact acatcttctg cagcaccccc ctcactaggt 361 gtagagttca tctctctgct ggctatcatc ctgctgtcag tggcgctggc tgtggggctt 421 cccggcaaca gctttgtggt gtggagtatc ctgaaaagga tgcagaagcg ctctgtcact 481 gccctgatgg tgctgaacct ggccctggcc gacctggccg tattgctcac tgctcccttt 541 ttccttcact tcctggccca aggcacctgg agttttggac tggctggttg ccgcctgtgt 601 cactatgtct gcggagtcag catgtacgcc agcgtcctgc ttatcacggc catgagtcta 661 gaccgctcac tggcggtggc ccgccccttt gtgtcccaga agctacgcac caaggcgatg 721 gcccggcggg tgctggcagg catctgggtg ttgtcctttc tgctggccac acccgtcctc 781 gcgtaccgca cagtagtgcc ctggaaaacg aacatgagcc tgtgcttccc gcggtacccc 841 agcgaagggc accgggcctt ccatctaatc ttcgaggctg tcacgggctt cctgctgccc 901 ttcctggctg tggtggccag ctactcggac atagggcgtc ggctacaggc ccggcgcttc 961 cgccgcagcc gccgcaccgg ccgcctggtg gtgctcatca tcctgacctt cgccgccttc 1021 tggctgccct accacgtggt gaacctggct gaggcgggcc gcgcgctggc cggccaggcc 1081 gccgggttag ggctcgtggg gaagcggctg agcctggccc gcaacgtgct catcgcactc 1141 gccttcctga gcagcagcgt gaaccccgtg ctgtacgcgt gcgccggcgg cggcctgctg 1201 cgctcggcgg gcgtgggctt cgtcgccaag ctgctggagg gcacgggttc cgaggcgtcc 1261 agcacgcgcc gcgggggcag cctgggccag accgctagga gcggccccgc cgctctggag 1321 cccggccctt ccgagagcct cactgcctcc agccctctca agttaaacga actgaactag 1381 gcctggtgga aggaggcgca ctttcctcct ggcagaatgc tagctctgag ccagttcagt 1441 acctggagga ggagcagggg cgtggagggc gtggagggcg tgggagcgtg ggaggcggga 1501 gtggagtgga agaagaggga gagatggagc aaagtgaggg ccgagtgaga gcgtgctcca 1561 gcctggctcc cacaggcagc tttaaccatt aaaactgaag tctgaaattt ggtcaaaaaa 1621 aataaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 1681 a (2) INFORMATION FOR SEQ ID NO:2694: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2694 1 gatcaaaatt tttacctatt atgcatttga tatataaata agtatataaa tgcacacaca 61 gacacagcaa tgatggtgaa cagtcttcat acaattatat ggatgaatct cataaaatgc 121 tgagttaaag aaatcagacc aaagaacata tactgaaaga ttctctctat atacaaagtt 181 caaaaatagg tggaccaatt catggtggtg ttagaaatca gaagagaggc tacctttgtg 241 gggaggggac agtttaatgc ccagaagcgg taaataagga atcctctggg gagtggtaat 301 gatctggatg ctggctacag gatgtgttgg ttgtaaaaat gcattttttt atatctagct 361 ttttccatgt gtatattata cttcaaagaa gttcagttaa taatttctca tgtcactgta 421 gagtagctca gttagcccca gcaagcctct ggcttaatct tgttttacct taagccatca 481 gtcatttaca agtaggaaaa ttcacaggga aagttagagt ataaaatcca gaatgaaggt 541 ttactgggta agagtctctc cattttccaa agcccgttta tttcttgatt ccagttctta 601 agaagtctca gcattgtgtc tttttcatgt atcttacaag aagacagcat gtgcttctaa 661 cacctgatac attgtatcta ccagcacttg gtaaacagaa aagaaccaca tttttcttgt 721 aggagaaatt tggtgcctat ttcctaccag gcaccaataa gtgggaccaa taggtgggat 781 taaagataca gtagaaagta tttaaaactt gccagggggc aatagtctga aaataagtaa 841 attggtgcta tagaatggaa gttacaggct tctttctttt ttcccacaag atctgctcct 901 tgagccccta gagacttttc tgtctgttac tgtttcttca ttcctcatct gcagagccag WO 00/09525 PCT/US99/17712 EPI-109 917 961 ccctgagaag tgcagaccaa agccagggaa ggctctgcaa agatgtacaa atggaagtca 1021 ccttaataac ctctgactgc tgcgcataat acatttcact caaaagaggg gttaaacaat 1081 ggaacagaat acagaggcca gaaataatgc tgaacactga caaccatctg atctttgaca 1141 aaatccacaa aaacaagcaa tggagaaagg actccctatt ccataatggt gctgggataa 1201 ctgtctagct atatacagaa gattgaacct gggccccttc cttacatcat atacaaaaaa 1261 taactcaaga tggagtaaag acttaaatct aaaaccaaac actataaaaa ccctggaaga 1321 tagcctggga aataccattc tggacatagg acctggcaaa gacttcatga caagacacca 1381 aaagcaatag caacaaaaac caaattgact aatgaaacta atgaaactct ttagttgtac 1441 aacagatagt ttatctgtac aacaaaataa actatcaaca gagtaaacaa cctacagaat 1501 ggaaaaattt tttgcaaact atgcatctga caaaggtcta atatccagaa tctataagga 1561 atttaaacaa atttacaagc aaaaaaatga cctcattaaa aagtgggcaa aggacatgaa 1621 cagatgcttt tcaaaataag acattcacac atccaacaac catatgaaaa gatgtttaac 1681 atcactaatc attagaggaa tacaaatcaa aagcataata agataccatc taataccagt 1741 aggaatgact actattaaaa agtcagacaa taacagatgc tggtgaaggt tgtggagaaa 1801 agggaatgtt tatgcactgc tagtgggaat gtaaactagt tcagccattg tggaagagag 1861 tgtggtgatt cctcaaagaa tgtaaaaccg aactgccttt caatccagca atcccattat 1921 tggatataca ccaaaaggaa tagaaattgt tttaccgtaa aggcgcatgc atgcatatgt 1981 tcattacagc actatttacg atagcaaaga catggaatcg tctaaatgcc catcagtggt 2041 agactagcta aaaaaaaaaa aatgtggtac atatacatca cagaatagta tgcagccata 2101 aaaatgaaca agatcatcat gtcctttgca gcaacatgga tgtagttgga ggccattatc 2161 ctaagcaaat taatgcagga acagaaagcc aaataccaca tgttctcatt tataagtgac 2221 agctaaatat tgagtacaca tggacacaaa gaagggaaca atagacatgg gacctacttg 2281 agaatagagg gtgggaggag ggtgaggatc aaaaagtacc cataggacac tgtgcttatt 2341 acctgggtga tgaaataatt tgcacaccaa acccctgtga cacacaattt acctatatag 2401 aaaacctgtg catgtaccc: tgaacctaaa agttaatggt gggggggtgg ggttaagcta 2461 ctttgtggta taaatctgag cattcatatt aaaataaaat atttacctca ttagagtaat 2521 taacatttat taagcaaaga gccaagtacc ttacacacat gatgtttaat ctcacaatga 2581 tctttaatct cataacaacc gtccattgta tgtacatatg tggaaattga gccttggaga 2641 gattaaatgc atggggcatg ccatttgact agaaactgga agcatcagga tttaaactca 2701 gttctgaatg gttttgtagg ctttgttttt tccacattat agcatggcct gccatgaaga 2761 acaggtcctt tctggtgttt gtcttgtttg gtttaagtga agcaaatatt tatttaaata 2821 ttcaagatat gctgttaaat ttttactcaa aaatttgagt acagtatgga tcttctgaag 2881 ccaaataact cttattcaat gcttagttga gaaattttat ggagtagttc tcaattttta 2941 tgtagttcca ctgcaaaggt aagtcttatg gaaagattca ctgtaatttt ttttcctcat 3001 ttggacatca gctttttctt ttcctcagac ccgctgaaag ataattttta aaataaaaac 3061 cttgttttta tatcaagtgg ggacattttt tccaaatgaa aaccgtgtat tcattttata 3121 tgataaaatc aatgttatta tttttaaaat tttgatttaa aaatcattaa aaataaattt 3181 tcagatatta cctgaaattc taccatccag agataatagt gcttaaagat ttgatatata 3241 gacacacaca catatataca tatatatcat cctaaacttc tttgtataaa tgtatataaa 3301 gtttttaata aaaactagga gattaatgcc ctttgaatga aaataaatac aatgtgtatg 3361 ctttaacatc ttgcctttac tttataacat ttatcacagc agtcatgaga taatgattta 3421 catggtcatt gttagtaagc taatagctaa gtgcatgaac tctggagcta gcctccctgg 3481 attttaatcc cagatctgtc actgaccagc tgagcaatac taggtaaatt gctcttgttc 3541 cttagtttct tcatctgtaa aatagagata aaaataatat ccacctcata ggattggtgt 3601 gagcattaaa tgagcatacg tatgtaggcc acttaacaac aatgccttca catactgaac 3661 acaaatatac gagctgttgt cttattgggc tcatgttttt cctaccacta agccgcatgc 3721 atgcaaggac catgttggtt ttgttccaca ttgcatcccc aacctggtat acagtgtgca 3781 ttcaatagtt gttgactatt attactagtg gcatttaaca aatatctgtt aaatgagtga 3841 agaaataccc atttactgca agtgtgtcta atattgatgg cataatgggg gaaactcaaa 3901 ctctggagtc aaacaggttt taaaacctta ttccctcatc ctcagttatt gacgtttttt 3961 ttttggcagg tgtgtgtgtg ggacaactta ttgaactttt ctgaatttcc agcttcgcat 4021 atataaaata gagatagtga ttcattcttg caatgtatgg atttgagaca attgtgtaag 4081 tttatcaata aatagtagct atttttgtat aagtattaca tataatatcc aggccactgc 4141 tttgcataac ccaaaagggg caccattcat gcagaataca acataaatgg tgtccctgga 4201 gcagtgcagt ataggaaccc tgaggggacc tacagtatac tttatagttc atagattaca 4261 aattatccct ttatcagagt ctctcaaggt tggatgtatt tgaggtccat aagagcaatt 4321 taggattaac agtagctgca gaaaccatct gcagtgatat tctcatttta aatccgcggg 4381 aaagaagaca gctataaact tgggacctgg gtttaagcat tttaaatgcc aagttcacca 4441 ttttctaaaa cacaacaaat acccagtgag agagggagaa gggaagtaaa tgcctctgaa 4501 taagcaagtt aatgtcagta gttgtactgt atgcatattg atgaacaata gaggaaccaa 4561 tgtccaatca gatgagcagg atatttggca ataacaagtt gcctttgagg aaaaatgatt 4621 ttcttggcaa gttctttatc agcattacaa agctaaaagc tacgcttatc atcacttata 4681 ctagcatacc ctgttgtgca aatgctgtct gtgtttgcat ctgctattgt tgatgcctgg 4741 tgcatgaatc aggactccag cccacaagtt ttcccagaac tttcttatgg ccatcatctt 4801. taagtgtctg gtgaacagtc atagtttggt acacaaaagg gtcaacctgg gggatggcta 4861 gggtttgact cagtcgttac atttcaatag agcaggaagg ggaaatggtg gcctgtaacc 4921 tcagggaatt ttgccagttg gtccacccca ctctctctct cctgctctga ggaagtggca 4981 cagcctagaa cagcaccaca ggtgagagaa atgcaaaccc taaccagaga agcagactct 5041 ttgccagtag taatagttca ggaccaccac cagcttttat taaaattttt aataacactc 5101 aagtattggc agaaagaaat aatcttgggt taactataac tagaatattg actcttcctc 5161 tgtggaagaa tcagccaatc acatttgttt acatcagttc ccctgaagaa gaaaaataca 5221 ctgatgttgc agcaagacaa atttaagcta gatgtaaata acttccttta gcctgtaatg 5281 ctaggctaat tacatattgg aactattttt tcagggaaga attgtgtagg gtttcaggga 5341 agaattctga agaaaatata gagctgaaat gatcttgcag ctcactgaaa ctgcagggtt 5401 tagatccaca ctgatactcg ttctattatc actgtaatga aggctgatgg aataagtaaa WO 00/09525 PCT/US99/17712 EPI-109 918 5461 aatgttttgt attagtatgt ttttacactt atttgcaagg cataaatagg ttaggttttg 5521 atcttaattt aattctaaca tgtattgtgc acaagctgtg agcagttttc aggagttagg 5581 tatctggcca tgactgattt ttcaggagtt aatcatctgg tagaagggtc atacacaata 5641 ggaagatgtg tgtgacaggt tgtgatcatt actataatca cacagagagc tgtagaattt 5701 taggctggca gggtggctca cgcctgtaat cccagcactt tgggaggcca aggcaggcgg 5761 atcaagaggt caggagatgg agaccatcct ggctaacacg gtgaaacccc gtctgtacta 5821 aaaatacaaa aaaaaaaaaa agccaggcgt ggtggtgggc gcctgtagtc ccagctactt 5881 gggaggctga ggcaggagaa tggcgtgaac ccgggaggtg gagcttgcag tgagccgaga 5941 tcgcatcact gcaatccaac ctgggcgaca gagggagact cagtctcaaa aaaaaaaaaa 6001 aaaaaaagtc atgttagatc cagaggggta gcaactgggg ctgggctgtc agtcaactca 6061 gtcaactcag tcaactctgc tcccccacag gagatgccag tgatgcattt tcatggccaa 6121 cattgtcagt cagcatcatt gaattactcc tgattataga gacacagctg caaacgattc 6181 cccattaaat atgatgtttc ttgcaatgtt tggaaggtac tcctttttag taagggaaat 6241 cccctcttct ggcttgctga aagttttttc tttccatttt aaaaatcgtg aattcctttt 6301 tgcaatattg aggtggttat atggtttctc ttctctaatc tgttaatatg gtgatttaat 6361 ggttagaaat tttctaatgt aaattccact catattgcag aaataaacct aaactgagca 6421 tgaggctata ttttttattt gcttctatat ttggttgcta tacagtatta tgtttaagat 6481 ttgttcacat atatttgtga atgggattgg actatttttc cttcttgccg atttttatct 6541 ggtttttaaa ttaaggatat tttagactta tgaaatattt ggcaaacaat ccttggcaag 6601 taattttttg gggaatttgt tttggctatt ttgagtatta cccaatatat tttaattaag 6661 ttattcttaa tgttttctta attaaaaaaa ttacctactc tagagatatt ctttatgtac 6721 tccagatttt gtctatttat accacttttc ttttttcctc gatgagtgtc atagatgttc 6781 atctattttt ttatcttctt tgatcttctc ttattccttg tttctattaa cttctgaagt 6841 ttattatttt cttttttcca cttccttatg gtttattctt tcaatttttc tctaacttct 6901 taagttgggt gtttaatttt tagcttgctt tgctttttta ggataagcat taaaactaca 6961 aattttcctt gttattcttt tgctgcaccc caaattgttg atatttctat tgtctaattt 7021 ctattcaatt agaatacttt aaagtttctt tttggttttt aaaaactaac tttttaaatt 7081 gacaaataaa aattgtgtat atttattgtg cacagcatat ggctttgaaa tatatgtaca 7141 ttgtggaatg gctaaattta gcttattaat gtatgcatta tctcacatac ttatcatttt 7201 ttgtggtgag aqctatgtga cttttgaact tatgagttat ttaaatattt ttaaattatt 7261 aagcatattg ggattttaag taatttacct ttttattatt aacttataac aagtagaaca 7321 gttaacctgt atgattctac atcattgaaa tttattgaca tttgcttcat agtctattat 7381 atggtctact tttgttcatg ttacatctgt agtagaattg gctaatagtt gagtaaagta 7441 cacatatgtc tatgaaatca agtgtaatcc agagaaaaag agaaatttac tgaatatatt 7501 gttctaggtg ctattatatg ttgtcatgtt taatcctcac cacaattgta tgaggcagcc 7561 ataattaatt ccactttaca catgaggagc ctgagggtta aaaaaaaagc tagctctact 7621 atttgtaaag aatgaagcaa agatacaaat gaaggcccac atatcctata actagatatt 7681 taagcatttt aattcaagct ttaaaactgc taaataaaat gtgctccaat ttctatattg 7741 acagacatac cttcctaatg agctggggtt cgaatttaga aatctttgat gcttcagagt 7801 ccacactgaa atgtggaggc acatagtgag ttggtcccca gccttcagtc cacccacctt 7861 ctctttacta aatcaccttt cacatacatg tatgaacacc ccagcctcca agtccaaacc 7921 ctaaacaaaa tgggacaccc ttgtgcatac acagagacac agcccatcct caggaaaacc 7981 tggaaaagtc catacaagtt ctggaagcaa gcttgggacg gtttcagtag tgtggtctat 8041 aagggaggcc tcagaagaca ggttttctta attctgtgaa cttctcccac agtagaaagg 8101 gtgctggagg agggtcagag tgaggacttc taaagcatgg gtcctgagta ggggccactc 8161 ttgcccaagt ctaagaaggg tactagaata gcacactact actagatact agaacccaga 8221 tacaagcaca ggtcttctga aattaataat aataataact attaccatta ttataccagt 8281 agctgtcatt tatttagtgc ttattatttg ccagtcactg ttctaaattc tttacatgta 8341 ttatacaact gccatataac tgccatatga gggatgtacc ctcattgtca ccattttacc 8401 gatgagaaaa ctggcataaa acgtttaagt aacttgtcca attacagag cttagtgaag 8461 ccacaatgtt gctcaatttg ctctcaaact tcaaagggat gggaaggaca cctaagtcat 8521 agagtcttta agaatcagag ctagaaggaa tcttagatgt tatctagtca gcctcctccc 8581 attacagtcc aagagaagat ggccctgagt tacttgtagc tatttttgca tgtgaattgc 8641 aagtgaatat acattctact gaagataaaa gatatttaaa gatatcgctg gatataggaa 8701 cagtggtttt aaatctctag gctttaactt ttctcagaac aagaaatcct ttttggtttt 8761 aatctatatg cacatctgta tttttctcaa ttatcgggta gtaaaatata acttttcttc 8821 tgtaatattt tttaacttta atgagtgttc ctcataatag aaaaqtttgg aaaccattgc 8881 tatgggtata tactttctaa agggatagta atttctctag aatattcatt taatgctcca 8941 gaagtaatta gcacaattgt gcaagtctqt gcatcatcaa ctatacattc tgcctgttta 9001 ctccaaatcc acatgaaact gattatacag tcaaaggcga gcccagtgga gaggcatttt 9061 tggagacttc ctggtacatt gagacagggt cggccagtct gcgttagggt cttggtcaaa 9121 actgcatttc tgaaactaaa ctcagattgc tttcttttaa ggggtcagaa ctgattcaaa 9181 tctacatttt taaaagcctt agatgtgggg cttttcctat tcccagtctc cgctattggt 9241 ctttgtgaat ccacaggcaa tttggccaca tccttgactc tctcttatat taagaattaa 9301 acagctaagt tcatgcagag gaaatataac aaaggaggga ctttcctaca agatctttga 9361 aaaatggaac atttgcataa gtcatattta gccagaactg ttgttttata ttttcctttc 9421 tgaatacttt gttacacctc ctcccagcca accccccccc tccctgaccc caactagtca 9481 gagaccaaag ccttcacaat ggtttacact tgaaccttcc tggccccacc ctcatcatca 9541 cgcctgaata attacattca ctgactggtc tcccctgctt ccgtttatct ccactcctaa 9601 accctctgac accttaatct tcccagaata ccattgtgat cctgttccac tcttgctcaa 9661 gttttcccag aaactagagt acaaacttta taagctttag agttgaaagc cactctatct 9721 ctttttcatc cccaggtctc tgccaaggca gtataacctg tccaacatct ctaacttcaa 9781 tacctttgtc ttagatacta gactctcctc ctggtttcta attaaacctg atctaggatc 9841 taattttgcc tctgaattct gttgcccttt gccaagtgat ctcttcctcc tctgagccgc 9901 agcatctctg agcttgcaca cttagcatag ccatagcaca cacagcctta gcttgcagtt WO 00/09525 PCT/US99/17712 EPI-109 919 9961 cagggtgttt accttccctc cccttccaga tgctggatcc ccagggatag gaactctgcc 10021 cttatgtgtc catagcccct ggtagtatgt cttgcagtcg tacattttca gcaaatgttt 10081 aattggttaa ttgaagacaa ctgtcccatg ccttaagcct ctctttttgc taaacatgcc 10141 tgtgtccttt gtcattgaac aactattttg atctattttc ttcctgacat aggggtcagt 10201 tccgaggatg ctgaaatcaa gagacatagc ttattctctc aaaattgctt tcaagagtga 10261 ttttgttgtg aattgagaac tggctgccta cttttggact acccacttca gcaagagtgt 10321 ttgaaaccaa atctattcta agtaattttt tattcccttt tctctatggc attagacaca 10381 cagctctttt aaactacctt tcgttatcta ttaaacagac attcagtaac tctatagaca 10441 ctgtctagct atatgaactt agacaaacta atatctctga gcttcagttt cttaaaattt 10501 aaaatgagga caataccatc tatggccggg gattaaatgc tatgaggaat gtaaaccaga 10561 tgtcaggtac catctctcta aaatccagat aaaatgaatt aaaaatactg gccgcaaacc 10621 ctctctaaga gttctcaaaa ttctcagaga gcttaatttt catgctcacc atagcaccga 10681 ttttcttcta aatattttgt ttctaccaaa atattttgtc ccaattttgc cttttatggc 10741 tatttcttca tatccacttt cccaaactaa agaagcagcc ccttcacctt aaactcctcc 10801 ttcaaagcaa cctaaataca ggtctgggtt tgtattccta gtgggatgtt acagaggtta 10861 gtgtgatgca gaggaggagt catgctgttt aaatccatac tagtccccag aggccaggct 10921 gcttctgcca cccctacccc tcccgccaca gagctcttca gcttctcaca tttctagttc 10981 ttctctctct actttcatta ccttctctct tttttttttt cttctcatgt gctcacggga 11041 gcagagaaaa ttaactcctc taagttttct taacacagag tgccttaatt acatattact 11101 attgtttgag ttcctgccaa cactacgtct gtagggtcac acctgctata ttagaggctt 11161 atcaaaaaaa gatagctttc tcctaaaaag ggatttggat gcctactaag ataactggat 11221 gccaagataa gtttaaccta acaaacttta ttattattat tattattatt attagagata 11281 ggtacttatt ctgtcaccca gactgcagtg cagggatgca ataatagctc actgcagcct 11341 caaagtcctg agttcatgca atccttctgc ttcagctccc tgagtagcta ggactacagg 11401 catatgctac tctgcccagc tacttttaaa aaaataatta gggatggggt cttgttgtat 11461 tgcccaggct cgtctcaaac ttctggtttc aagcaatcct cctgcctttt acctccctaa 11521 ttgttggagt tacaggcatg agccacagca ctcaaccaag atttaaaaac ttttaaaaga 11581 aatcacatta cttactgtta tcatcattat ggttactacc agtgttaaaa caattggtat 11641 tgaaaacacc actaccagat caagcttcaa accaagatgt caagtaaata ttattgtcag 11701 acctctgagc ccaagcctgc aggtatacac ccagatggcc tgaagcaagt gaagaatcac 11761 aaaagaactg aaaatggccg gttcctgcct taactgatga cattccacca ttgtgatttg 11821 ttcctgcccc accttgactg agggattaac cttgtgaaat tccttcccct ggctcagaag 11881 ctccccgact gagtaccttg tgacccccac ccctgcccac aagtgaaaaa ccccctttga 11941 ctgtaatttt ccactaccca cccaaatcct ataaaacagc ctcaccccta tctcccttcg 12001 ctgactctct tttcagactc aacctgcctg cacctaggtg attcaaaagc tttattgctc 12061 acacaaagcc tgtttggtgg tctcttcaca cagaccatgt gacatttggt gccgtaactc 12121 agatcgggga acctcccttg ggagatcagt cccctgtcat cctgctcttt gctccatgag 12181 aaagatccac ctatgacctc tggtcctcag accaaccagc ccaaggaaca tctcaccaat 12241 tttaaattgg gtaagtggcc tctttttact ctcttctcca gcctctctca ctatccctca 12301 acatctttct cctttcaatc ttggcaccac gcttcaatct ctcccttccc ttaatttcag 12361 ttcctttctt tttctggtag agacagagga aacgtgttct atctgtgaac ccaaaactcc 12421 agcactggtc atggacttgg aaagacagtc ttcccttgat gtttaatcac tgcagggatg 12481 cctgcctgat tattcaccca catttcagag ctgtctgatc actgcaggga cgcctgcctg 12541 gatccttcac cttagtggca agtaccactt tgcctgggtg gcaagcacca cctctcctgg 12601 ggggcaagca ccacctctcc tggggggcaa gtacccccca accccttctc tccatgtctc 12661 caccctctct tctctgggct tgcctccttc actatgggcc accttccacc ctccattcct 12721 cccttttctc ccttagcctg tgttctcaag aacttaaaac ctcttcaact cacgtctgac 12781 ctaaaaccta aatgccttac tttcttctgc aataccgctt gaccccaata caaactcaac 12841 aatggttcca aatagcctga aaacggcact ttcaatttct ccatcccaca agatctaaat 12901 aattcttgtc gtaaaatgga caaatggtct gaggtgcctg acatctgggc attcttttac 12961 acgtcggtcc ctccctagtc tctgttccca atgcaactca tcccaaatcc tccttctttc 13021 cctcctgcct gtcccctcag tcccaacccc aagtgtcgct gagtctttcc aatcttcctt 13081 ttctactgac ccatctgacc tctcccctct tccccagact gctcctcctc aggtcgctcc 13141 ccgccaggct gaatcaggct ccaattcttc ctcagcgtcc gctcctccac cctataatcc 13201 ttctatcacc tcccctcctc acacctggtc cagcttacag tttcattctg tgactagccc 13261 tcccccacct gcccaacaat ttcctcttaa agaggtggct ggagctaaag gcatagtcaa 13321 ggttaatgct cctttttctt tatccaacct ctcccatctc agttagtatt taggcttttt 13381 ttcatcaaat atgaatacct agcccactcc atggctcatt tggcagcaac tcctagacat 13441 tttacagcct tggacccaga ggggccagaa ggtcatctta ttctcaatat gcattttatt 13501 acccaatcca ctcccaacat tagaaaaagc tccaaaagtt agactccggc cctcaaaccc 13561 cacaacagga cttaattaac cttgccttca aagcgtacaa taatagagta gaggcagcca 13621 agtagcaaca tatttctgag ttgcaattcc ttgcctccac tgtgagagaa accccagcca 13681 catctccagt acacaagaac ttcaaaatgc ctaagccaca gtggtcaagc attcctacag 13741 gacctcctcc atcaggatct tgcttcaagt gccagaaatc tggccactgg gccaaggaat 13801 gccctcagcc tgggattcct cctaagccat gttccatctg tgtgggaccc cactggaaat 13861 cggactgtcc aacttgccca gcacccactc ccagagcccc tggaactctg gcccaaggct 13921 ctctgactga ctccttccca gatcttcttg gcttagtggc tgaagactga tgctgcctga 13981 tcgcctcaga agcctcctgg accatcacag atgcttttgg taactcttac agtggagggt 14041 aagtccgtcc ccttcttaa.t caatgcagag gctacccact ccacattacc ttctcttcaa 14101 ggtcctgttt cccttgtctt cataaatgtt gtgggtattg atggccaggc ttctaaaccc 14161 cttaaaactc cccaactctg gtgccgattt aaacaacatt cttttataca cttcttttta 14221 gttatcccca cctgcccagt tcccttatta ggctgagaca ttttaaccaa attatttgct 14281 tccctgacta ttcctggact acagccacat ctcattgctg cccttcttcc caacccaaaa 14341 gtggcaactc ctttgccact tcctctcata tccccctacc ttaacccaca ggtatgggac 14401 acctctactc cctccctggc aacaaatcac accctcatta ctatcccatt aaaacctaat WO 00/09525 PCT/US99/17712 EPI-109 920 14461 cacccttacc tgggtcaacg ccagtatccc atcccacaac aggctttaaa gggattaaag 14521 cctgttatca cttgcctgtt acaacatgtc cttttaaagc ctgtaaactc tccttacaat 14581 tcccccattt tacctgtcca aaaactggac atgccttaca ggttagttca ggatctgtgc 14641 cttatcaacc aaattgtctt gcctatccac gccatggtgc caaacccata tactctccta 14701 tcctcaatac ctccctccaa aacccctcca taacccttat tctgttctgg atctcaaaac 14761 atgctttctt tactattcat ttgcaccctt catcccagcc tctcttcact ttcacttgga 14821 ctgaccctga cacccatcag cctcagcaac ttacctgggc tgtactgccg caaggcttca 14881 tggacagccc ccattacctc agtcaaccca aatttcttct tcatccatta cctatccagg 14941 catagttctt catgaaaaca cacgtgctct ccctgctgat catgtccagc taatctcccc 15001 aaccccagga ctggcaaatt gactttactc acatgcccca aatcaggaca ctaaagtacc 15061 tcttggtctg ggtagacact ttcactggat aggtagatgc ctttcccaca gggcctaaga 15121 aggccaccgt ggtcatttct tcccttctgt cagacataat tccttggttt ggccttccca 15181 cctctataca gtctgataat ggacaagcct ttactagtca aagcacgcaa gcagtttctc 15241 aggctcttgg tattcagtga aaccttcata ccccttaccg tcctcaatcc ttaggaaagg 15301 tagaactgat taatggtctt ttaaaaacac acctcaccaa gctcagcctc caacttaaaa 15361 aggactggac agtactttta ccacttgcca ttctcagaat tcgggCctgt cctcgaaatg 15421 ctacaaggta cagcccattt aagattctgt atggacgctc ctttttatta ggccccagtc 15481 tcattccaga caccagccca acttgaactg tgccccaaaa acttgtcatc cctacaatct 15541 tctgtctagt catactccta ttcaccattc tcaactactt gtaaatgccc tgcccttttt 15601 tacagtgctg atttatactt ttcctccaaa ccatcataac tgatatctcc tggttttacc 15661 tcaaaccgcc acccttaagt ctctcttaaa gtggatagaa gatcttcagt gacaaggtac 15721 actccaatac tttcacccta ataaagccct attctttact tttatattca ctcttattct 15781 tgttcccatt cttatgccac tctctacctc tccccagcta tctccaccac actatcaatc 15841 tcactcactc tctcctagcc atttctaatc cttctttaac aaacaattgc tggctttaca 15901 atttctcttt cctccaaaat caccgagtcc tcaatttact cactgctaaa aaaggggact 15961 ctgcatattt ttaaatgaag agtgttgttt ttacctaaat caatctggcc tggtatatga 16021 caacataaaa aaaactcaag gatagagcca aaaaccttgc caaccaagca agtaattatg 16081 ctgaaccccc ttgggcactc taattagatg tcctgggttc tcccgattct taatccttta 16141 atacctgttt ttctccttct cttatgcaga ccttgtgtct tccatttagt ttctcaattc 16201 atacaaaacc gtatccaggc catcaccaat cattctatac gacaaatgtt ttaagggagg 16261 agaccacccc tcatattgtc ttatgcccaa tttctgcctc caaagaaaga agtaaaaatg 16321 aaaaggcaga aatgaaatcc acaggcagac agcctgatgc cacaccctgg gcctggtggt 16381 taagatcaac ccctgaccta atcagttatg ttatctatag attacagaca ttgtatggaa 16441 aagcactgtg aaaatccctg tcttgttctg ttcctctaat taccagtaca cgcagcccct 16501 agtcatgtac cccctgcttg ctccccctgc ttgctcaatc agtcatgacc ctctcacgca 16561 gaccccctta gagttgtaag cccttaagag gaaaaggaat tgttcactcg gagagctcgg 16621 tttttgagac atgagtcttg ccaatgctcc cagctgaata aagcccttcc ttctttaact 16681 cagtgtctga ggggttttgt ctgtgtcttg tcctgctaca gtttcatcta acaaccccat 16741 aatatcaccc cttaccacaa aatcttcctt cagcttaatc tctcccactc taggttctca 16801 cgccacccct aatcctgctc gaagcagccc tgagaaacat cgcccgttat ctctccacac 16861 cacccccaaa aattttcact gccccaacac tttaccacta tttcgtttta tttttcttat 16921 taatataaga agatagaaat gtcaggcctc tgagcccaag cctgcacgta tacatccaca 16981 tggcctgaag caagtgaaga atcacaaaag aagtgaaaat ggctggttcc tgccttaact 17041 gatgatattc caccattgtg atttgttcct gcgccacctt gactgaggga ttaaccttgt 17101 gaaattcctt cccctggctc agaagctccc ccactgagca ccttgtgacc cccaccccta 17161 cccacaagtg aaaaaccccc tttgactgta attttccact acccacccaa atcctataaa 17221 acagccccac cccatctccc tttgctgact ctatttttgg actcagccca cctgcaccca 17281 ggtgattcaa aagcttcatt gctcacacaa agcctgtttg gtggtctctt cacaccgaca 17341 cgcgtgataa ttattatatt acttttaact aaaacccttt cagagtctcg cagggaaggc 17401 tgtatatatc tcataaaatg ttggggccca ctggatcaga caaggccaca aaggccaaag 17461 ggaagtaaag atctcattat ttctcctaat aatttccctg tcctttgtca taaatggtgg 17521 gtaggctgtt atggtgatgg cagattttct ttccataaaa tgtccataat aggacatttg 17581 aacagaaggg aaaaatcaaa ttgctgaagt tgaaagaggg caatgcaaag aactttggag 17641 aaagaactgt acagagaagt caactggcag atgggaggaa gtttaagggg aaaaatatag 17701 atgtctaaag aatacattta ttcattttcc acagtgcaat ttggacaaga agcctctttc 17761 ttgcttcttt ctattctcat taaatcatta gagctcaagc aatccttctg cctcagcttc 17821 ccgactagct aggactacag gtatgtgcta ctatgcccag ctaatttttt aaaaattaga 17881 ttttaatttg gtgaactatt tctgtaggaa actacaataa tacagcccag gcacattgat 17941 cttgggtgaa caaatcagaa ggaatgaata attctgtgtt cctgggactc tgacaatttc 18001 atgaacttgg tactctgagt aaagcatagg aggagttatt tcataaaatg tggagcacaa 18061 tcatgtgaca aagataatgg gatccccatt tcataaataa atctgaagtt cagagagagt 18121 aacaactggc cagggtcaca tcacggagac agaggcaggg ttcccactga tgcctctgac 18181 tccctgtccc aggcccttcc tcctcccgca agcagaagtg cagggggcag agctgaccct 18241 gtgcagtgaa aatctgaggg ctgagttcct attggaacac aagtgaaaga cttcctggct 18301 tctaatctca ggataaggac tcagagctcc atctgttcca gccttaggat aagaaccaga 18361 atcttacacc atgaaagcat gaaaggtaag atttgagtga ggaaaaaaaa aaaaaaagtc 18421 tgtgtttcag attcagttca caaagcagtt tcatacttaa ggtaccatca caataaccct 18481 gtggggtaag caaggcaaat ttcattcttg ttttatgggc ataggaagta agtctcaggg 18541 aggttaagac caaggtttct ggagaatttt atattatgaa tcttgattta tgggattact 18601 attatgtaat tcctaagatc atataggaat cctagagctt gaatatagaa ctttattttt 18661 aaatctatat acatcataat tacaaggagt agtgtccatt tgggttcctt ggccctgatg 18721 tgttagtgga ataaacattt ttgtcagggt tgccatgtgt gtctgtgcac gtgtgcactg 18781 tacacctcca ggggatgtac cctaaaccac atgaatgtga tttgcacatc caagatttac 18841 agtgtactat agggagaatc ttttgcaaca gcttttgcta taatacagaa tctgagatgt 18901 ctttgagaaa gaaaagtgta atcattacca aaaaattatt ctcataatgt gtgcaaattt WO 00/09525 PCT/US99/17712 EPI-109 921 18961 gtatgaaatc tatattggcc atgggacaag gaggtatttc cagctagctt ctgaaagggc 19021 tctattctct cataagaatt cagctgttga cattaggtga tatctgccca ggtcatcaga 19081 tgccatagag aaagagggtt tgctgaaact tatatcagca gtgcactgta tgctctttct 19141 gatttatttg aacattcatt tattgagtgt caagtaatgc actagatact ccagggatct 19201 gacacaaact ctgccctgaa ggagcatgta atctcactgg ggagaaaaca aaacatatga 19261 taatttcaaa ataacaaact aggcaaacta gttaacactt aaaaagcagg ctttattcaa 19321 atgcaaaatt gcatgttaca gggtaacctt tcagtaagaa gccaggaaga ggagctcatc 19381 atgggttgga ttagtaaagg actagttata aaagaagtgg tggggttgag ggaggcctga 19441 gatgaaattt aaagaatatg tagaatctag gtaagtggat aaaaggtctg ggggcagggg 19501 aaaggagagc atttcattgt gaatcaagga atttctccac ctgttttaac tcttccatat 19561 gacatcaaag agatgtcact tgcagctagc atttcagtga tgttttctta ctaataatat 19621 cgtgataaaa gaaacattga ctataagaaa taggaatggg tctcataaaa ggaaacagca 19681 aaacccccaa actaaaaaac agcgcaggct atttctctct tctctccttt tgcttggcac 19741 tcatgagatg ctaggtgtgg aagtcagcca actgaaaaag agaggtggct gaagaaggtg 19801 gggaggctga agccagttaa ataggatggt ccaattcaca gacggcgagg ctacagtgca 19861 aataggactc tttcaacttg agcaggaccc cattacttca ctggagttag aaagaaagga 19921 gagcgtagac tttttgaact ttctataaga gtgtacctcc acagtataca gaagacgacg 19981 tgaaatttga tctgcaagaa aactgagtcc atattcacat atgtatcaaa tttgcacttc 20041 atttagaagt gtctgtcatc aagtacagca ctgaattgaa actgaaaaca agagtcaaga 20101 aagagcaaag tcagccatct ttatattcca catgaatcct ttccctttat ggtcttattt 20161 gtttctcctc agaaaagaca aaaagctgag ctgtataaac acctgtgggc tgggggttga 20221 gggataaatg aggggcgaaa tggaagctga aggaactgtt ggtcaggtag aaatcttccc 20281 agatgcactg aaggaaacac acttcatgtt tgacgtagga ggtgccacca cacaaaacgt 20341 ttcatggaag gatttaaagg atctcatgat ttttagtatt ccaagaattt tctttcacca 20401 agggcgattt aatatgggtc attcatactg aaagaaaaac aaaagataat aagagtttaa 20461 aaattgcaaa acttggagtg ttagtagtaa aggtaaatat tcattagaga tgagaagagg 20521 agcaaggaaa tgctttcagc tggaaatctc agacaagagg ccaggcttta ggaacctctg 20581 aagatgaaca aatgtaagca aaccctagta gcagcacttc tcagattttc atgtgcttac 20641 cactcagaga tggtgttaaa atgcagactc tgattcagta ggtctgagtg gagcctgaga 20701 ttctgcaccc ctaacaagct ctttagtgat gcttatgcca ctggcgcaca gaccccactt 20761 ggagaaattt ttgtggtgca tacggtcttt gtctccagat ctaatgagtc tgaaggacag 20821 tgtagattga ttttttaaat ttatgtttat tttaatttaa tttaatttaa tttatttatt 20881 tatttatttt tgagatggag tctcactctg ttgcccagtc cggagtgcag tggcacggag 20941 gcagctcatg caaccacggc ctcctgggtt caagcgattc ttccgcctca acttcctgag 21001 tagctgggaa tacaggcacg tgccagcaca cccagctaat ttttgtattt ttagtagaga 21061 tggggtttca ccacattggc caagctaatc tcaaactcct gacctcatga tccacctgcc 21121 acggcctccg aaagtgctgg gattacaggc gtgagccacc gagcccagct gtagattgat 21181 tttgagcagt ggaaagtcaa ggaattagaa ggcatgctta aatggaaagt gaaattggag 21241 aaaatttaaa ctcatgaaat agtggtggtt ataaactcgt gataaattat atcctgggat 21301 ataatttaat gagatggtaa cacatttagt ttaaagaaat aagtgacact ttttttgtgt 21361 gacacaactg tcttattctt ggaaaggaca aggagagaat gaaatatggt atgtcttcac 21421 agcacctttc aaagggagaa ccagattctg aggagctggt ctcatgatga actgtcaggg 21481 taaaccacag ttcagcagct gcaaatgtgc ttgccaaaat agagacaaaa aaatgtttct 21541 gaaaacaaaa tttcacatat gccctcctct gaggttggca tcatatcttc ctgtgtatct 21601 tgggtgtagc ttctatcctg ccagaattta gacagtagaa accaaatgag gtgataaaca 21661 gagtcatttt gcagaagagt caaaataacc cagcaagaaa tgaaaccaca aatgcccaag 21721 gagtcattca ttcaccattc aaaagctaat agaaatgaac acaaactact atgaaaattc 21781 acccaagaac ttaaaaaaaa aaaaaaaggc tcatggtgtt tagtgtgata gtattcattt 21841 tacctttgac ttgttctaaa aacacaccat acttctaccc cacccttcct cagtgccgtc 21901 acacaatggt ttcagtgtga aaaaaaaaac cacgttactg gaaaaggagg gtgcctggga 21961 cttgccactc taagctggta gtcaagggtc ttgagttcta aaagcatacg cgttaagagc 22021 atgattcctg gatccaaatg agtatggatc tcagcattgc catttattgt gacctcaggc 22081 tattttattt ctctgtgcct gtttctttat cagtaatgaa gatgttcata gacccttctc 22141 ccacagactt aaaggcatat ttcatgattt aagacatgta aaccattcat aacagtatac 22201 aacatggaat taatatttga taaaggttta tgattattgt aactaactct gtcacttgct 22261 caaggcctat agaaaactta cttaattagt tcaactacaa aaagagtttg aatgtgatat 22321 ccaccaagat catattcaga cctagaattc tgtgattctt atgaattaat acagccttgg 22381 tcaataaatg agagctgggc aaataattct tctttgctag gcctttctag accatctggt 22441 gaagcattca agacttatgt tattggggcc agccttcctt tccaacttca actccacaac 22501 tcctcaataa gccatgggct caagaaagtt ctgctcagtg gcccctgaaa aatgctttca 22561 tagtctcact accataccac tgcttacaca atttccttcc tacagactgc cttcctttcc 22621 tgcttttctc catataccta aatcctatct attcttcata agcaaccttc tttataacat 22681 tttctataac caccaagcca aatgaccttt tccttcttaa atatagcacc cattggccat 22741 taccatgctc tgccttgtat ttttctgatt tttttctttc tatattcctg tcttaactcc 22801 ccagctaggt aataattttc ctgaaatcag ggaccaggct gactcctctt gctgtctcaa 22861 gaaagcttag cagtttccaa cacaaaaatg ttcaataaac aactattaat tgactgatta 22921 taaaaaatca gtgaaccatt aaacttaata tagcaatttg cttagcatgg taattagctt 22981 tttgctaata ttcttccagc cagtctctcc tcctgtgcct caaggacatc ttaaaaaaaa 23041 aaaatctagt tgatctgctt ccatctagtg gcaattaaaa caggtggttc cggtagccag 23101 aaaacagctc tgggtagatt gtgccagaaa atactttcac tcagtaggtg cgagtttgaa 23161 agaaatcttc acatctgtgg gtttcctgcc acagacatag ggagaccagc ccagagaaag 23221 aagcctttcc tcactagact ccatttgcac tagtaaagag aagacagagt aattaaaaag 23281 aataaaaaga acctccactg atcgtacatc ctcatccagt tacccctgcc ccacttctcc 23341 ttcacagcca aacattttaa aagagatgac tgcttgttct gtctctactt tctcatcctc 23401 agtaatgctc aatgcttggc cgtctgacct ctgtcttgat gtctgcact caaatagtct WO 00/09525 PCT/US99/17712 EPI-109 922 23461 ccccactgac acccttgttg catccagggg atacttactg gttctcttqg caatgtttga 23521 aaccgttccc ctttctttgt ttccttggca ttcattaccc cacactcttt ctcctcttcc 23581 ttctccctgc ctggcaacat cttttcattt ctctttccct taggtgactt attagataat 23641 gatgttcctc tggctcccat actctctccc aggtcctctt ccattcttaa agcactcaca 23701 ccctccctgg atgatagtac ccactcctga gatggcagtt acctcctgaa atgtgaggga 23761 cccaaatcca cttctcctgc catagcctct gtgctttgga taggtccaat gagccacagt 23821 gaatgatgtg catacaccca aagctcagta caaaactgaa cccatgatct ttacctccaa 23881 aacctctcat tcttttatgt tcccttctca gaagtaaaca ggactaccat ccgccagttt 23941 ccaggtgaga aagatgataa tttgattctt ctctctcact tttagccaat taacagacac 24001 attcagttaa tatcacctc.c tcttatttca tgaacccatt cttactacta gttccctaga 24061 caggcgccat cggttttaat ctaataactg caaatgcctc caaaacaagt ctctttgaat 24121 ccaggctcac ctgtctccca cacttgCcat actgctctgc agggtgacct tataagatgc 24181 cagaggtaag gctactcact gtttaaaccc ctttaqtgat atcccaaaag acctcaagat 24241 aaagcccata tcacatggct tatacattag tttatgatct ggcttctggt gcctcatttt 24301 tccccacttt ttcctttgca ttctaagcaa tggcccatac taagtttgtg attggtagga 24361 tggttgccca aaccagcatc caatcccttc agaaatcatc tcacttcatt tctagcattt 24421 taaaggaagc tcagttgtcc agctgggtac tgaatatgtc accaaagtcc tcctttcata 24481 gtttatttta cttaaactct ccttcctaaa attccagagc aagtcactaa accctagata 24541 ctgagaaata tttttccatc ttcatttctg ccaggtgggc catcaacttt cacatgtctg 24601 catctcctcc cactgtgcta tttctccagt agaagaaatt tgagcttcaa gaccaaactg 24661 aaaaatactt gcctccttgg ggaagctgta ggtagaattc atgctcccta tctttcccac 24721 atttctgaag gacaatgcct gttagagcaa ttgaatgcaa atagtcaatt gaataagcat 24781 ttattcattt ctcaataagt gcttgttcaa ttgaatattt cttaaataat atatttaaga 24841 acaagaagaa cacaccacaa tgtttttaac cctcagaaaa aattctgagg taatcagaaa 24901 aatctccctt tacataaact gcccttttct aatagggatt acttgttcgt tcattcattc 24961 attcagctcc actagcacca aaaagcacag ctctgaaagg aagctagtag atttatcacc 25021 ttatctggtc atttggatga ggaccccagg taaataaact actatggggt taatgtgtct 25081 agctagagca ggaagtaact taaggaagta gagaatgaat cagcagatgt ggaaactcct 25141 cgccactaat aaaacttacc ttctcttgga tttcttgcct gaaaatagaa aatagagaaa 25201 aggcattagc aaaaattaga caatttaaag tttttcaagt aagggagaag gaagactccc 25261 actctcaaaa ctgtcttttg aagtatatta ggtatttgtt aggtggaccc tatctgtgtc 25321 aaaggagatt tgaggaactg gcttaataaa cagtggtaga cactaataca gaacagacat 25381 gttgatgcag atgcctcctg aggttccatt ccattctccg tgctactcaa gaagacagaa 25441 ttgctaaatt gcctggtggc aagacccaat atgtccattc aagtgtttat cccttcccaa 25501 tctgccatct catcctacct gcagattctt cccttgaggg acaqctgcta atactgtaaa 25561 actatgtgcc attacagctc acagcatcat ctctatgaga atccacaaga gaatttcact 25621 ttggtcttgt tggtaggaat tgtgcagcct catctgagta actaatgtgt ttttatctta 25681 caaacacaag gaatatcaca tggttctcct ttgactggct gtaaggaaac tcagagctag 25741 atctgagacc ctctcctacc aagtatataa aactttgtga catacatttt tgtgccataa 25801 cttcaacctt ggttccaaat gatttttgta ccctaagttt aaatttggct ttcttttttt 25861 tttttttgta ctcaataaaa catcaagctc atttattatt gcgaagagcg aaacaacaaa 25921 gcttccacag cgtggaaggg gacccgagtg ggttgcccaa attggcttct ttttcttact 25981 ttttaattaa ttttaatttg ctatactgaa cacattttgt actgttctca cattcttttt 26041 gaaaaaagca gaatataaat aagtagataa cttaaaaaaa actctttgag cagaaagaat 26101 catttgggag gcaatatatt tcagtggctg taaagtggca ttctagaatc atcctaccca 26161 ggtgaaagcc ctattttgcc acctgtagtg tagtgtgtat ttgaacagct actttctttt 26221 ctaaactaca atttcttcat ctgttaaaga ggcataataa ttgtatcatc ctcattgggt 26281 tgataaaata aaatatttcc aagtatttag ttcaggtcct agcacgtaga cagtgttgca 26341 ttactgtttt aatcctttaa agtattaaag actactattt gaaatctttt cttctaaaat 26401 tcagcctgct gatgaccaag tgcacttgag cagggggaat caaatctgaa ttaatttcag 26461 attctggtta gcttcacata aatatttttt ttagggatga tgaacctaac agcaatagat 26521 gagtaagaat ctgttcctac tgagagagtt tcattttgaa gaaaaaggaa ctaagggggc 26581 atgtgttcag tttcatgccc tggtctaacc ctgtgtgttg gttctggtgg gaaattcttc 26641 caaccgagga aaaaaccagt tcacaaatct gaagaccagt gattttagaa gatgtatctg 26701 gactggagtc taatctctga ctctgggtcc tgctgatatg gtatttttga gatttggcct 26761 aaaacatcat tgccctggtt tccttattta ccaaacaggg ccaatggtag tgactaatca 26821 gaaaatgata atgcctggtg cacaaaatgt gtctagatga gcccatgcac aaggacacat 26881 gtttctggaa ctgttcctta ttcctttcct aaaagaaagg agggaaagtc tccatactaa 26941 gactactagg gcaggggaca aagtgctaga gtcagaagat tcatctgagg acagaagaat 27001 aggggtgaag gctctagtca cttcattggc taccatgctc taaatagtta cctgtgccct 27061 ttttctaact attagaaccc aaaaagccta taaattctct ctctctctct ctctctctct 27121 gtgtatatat atacatatac acacacacat agacacacac acacacctaa acacacacat 27181 agagatttat gactttttac ttttatcctt gtaaatgcca ttaactatat tttgtcttag 27241 atttagcctg ggaatgtagc cattatttct accattgcct ccataggaaa aatactcttc 27301 atgttttaaa ggaccaacct acaactaaaa tctttggaaa gcagaatcat ttgtaagttg 27361 gtgaaaatgg aagatgttgt tttataaatg aagacttttt tttttttttt ttttgagaca 27421 gggcctcact ctgttgtgga gtgcagtggt gctgtcatgg cttactgcag ccttgacctc 27481 ctgggttcaa gtgatcctcc cacctcagtc tcctgggtag ctgggactac atgtgcatgc 27541 taccatgcct gactaatttt ttgtattttt qtagagatgt ggtttcgcca tgttgcccag 27601 gctggtcttg aactcgtggg ctcaagtaat cctcctgcct cagcctccaa aagtgctggg 27661 attagaggtg acagccaagg tgcctggccc acagatgaag actatttaat gttatcttaa 27721 agatacccta agcttcctac caagccagtg atcttttggg gcttctgttt tctttgttgg 27781 cataactgta actagcctaa ctgcccgtta tctgtttcct gtttgccca cactgattcc 27841 cacagcagtt ttcaagttat cggtttgaga tcttgtacag aaatgactcc aaggtaaaaa 27901 atttaaaaac aacccctcta atttttttac ccttgcttat aaaacagcct tagccagcta WO 00/09525 PCT/IUS99/17712 EPI-109 923 27961 acccctcact acatgcaaat gagtttgatt ctattctttt gattctacaa acacttatta 28021 aaagatttta gaattcggaa ataaatagct tccttattaa ggtgacttac agccccaaag 28081 tccttaaaat tatttagaca atagccacct tatcccaggg ggcagtgtgt aataacccac 28141 cctgttctct atccgtcagt zctgccatca tcgcccaagg taggaagaaa gacaggacaa 28201 ccggggtcaa gatttgaagt ctcaatggaa agaataatca gtggttggag aaaactgtca 28261 ttcttctttt gccttaatgc agtacttgat acttatactt agtactgtat agtacttagt 28321 actgtataat actataagat agtgagattc aatcagcaca gaatttctaa tagcaagggc 28381 agagacattt taactgctca gtgctctcag gttatacata gctaatgaag ttcttgcata 28441 tcaacaatcc ccacccccct cacacacttt gtctttctgg attggttaga aaacttacct 28501 agcgcccact attctcaaat ttaaatgaaa gataagatca gagtggcacg caattaggga 28561 ctgataaata atatttttgt aattgccagt gtaaatggac agggggcaac ctttacatac 28621 catattcagt gaacagaata cgtactaact aatttgatgg aaggaaaatt aaaatgacaa 28681 tcaactgagc ccacaqaaag gcaacacaga gcagttggtt agcaattgtt tcgagatcat 28741 ccctgaactt gaaacaggta tatctttttt tttttttttt ttgagacaga gtctcactct 28801 gtcaccaggc tggagtgcaa tggtgcggtc tcagctcact gcaacctccg cctcccgggt 28861 tcaagtgatt cttctgtctc agcctcccga gtagctggga ttacaggtgc ccgccaccac 28921 gcctggctaa tttttgtatt tttagtagag acagggtttc accatgttgg ccaggctggt 28981 cttgaactgc tgagctcatg atccgcccgc ctcggcctcc caaagtgctg ggattacagg 29041 catgagccac cacacctggc caaaacaggt atatcttaaa agctgcccaa tgtccatgaa 29101 tgttacagcc ttgaatggtt cttccaggtg agtttggcca aatgtggcac catacaccca 29161 aggcctgctg caggctagtg ggttgctcac actttaaagc tgagacacac tcatgcctta 29221 aggtaaaggg agtgataatc tgggcagcag atgttaactt ctcaaggcag tcctccttct 29281 cttttcctct ccagtgacgg atggttggaa agcatatatg gtgcatttgg ttagagctgt 29341 ggccttggtg aatagatact tgggagaata catgggaatt tctcccaggg ttaatgcaat 29401 gcccatgtgt tgggaaccag gtgactcttg aagaggtcag gtatttggga gcagtgcctt 29461 gaaaccttag tggacattag acccacttcc tagtggaatt gtagcattga aatccaaggc 29521 atgtaggctc ttagaggaca gagatagtgt gtcatttttt cagaattaat taagagcagg 29581 ccaggcgtgg tggctcacac ctgtaatcca agccctttgg gaggccaagg caggcagatc 29641 acgaggtcag gagatcgaga ccactctggc taacacagtg aaaccccgtg tctactaaaa 29701 atacaaaaaa ttagctgggc atggtggcac gctcctgtag tcccagctac ttgggaggct 29761 gaggtgggag aatagcttga acccagaagg cggaggttgc agtgagctga aattgcacca 29821 ctgcactcta gcctggtgac agagtgaggc tctgtctcaa aaaaaaaaaa gtattaaaga 29881 attacataag agcaaagaac cattagaata tctcacttag ttgttatcag cctagcaagc 29941 tgccttgaag gtaatagaca tttttaaaag tttatcagat gaaaagcgaa aatcagccaa 30001 cctgttttaa tgaaggtgtg tcctgggctg atttacatgt ctccagggac tgatggctct 30061 agaatgtaaa gcttggcatc ctgcttgtgt tgaatctatc acatttaatt tcctgtgggt 30121 ttcttttttt tttctttttc actttaaagt tgtgttcttt tcatgtgaag ttaaactcac 30181 ataccttttt ttaatctcct tgccagccaa atgataaatg ccaacccaga gaatgcagta 30241 accatgactg ccactggaat gaagaggggg ttataatcac cctccttaat cattgagaaa 30301 cttttgtcca attctgaaag agaaatcagt aaggcacata gcatgagacc accagcatta 30361 tttccttagt ctatctcatg atatttgact tttttcctcc ttacatctcc cagtagtagc 30421 ccatttgatg ccatttgaca gatgaggaaa ctggcatggg aaggcccctg atgagtctac 30481 agcataggca aagactggac cagccttgct agtctaatgc ctacagaatc tcaatgccca 30541 gatttgtggt tcatagagtt cctgaaaatg cacctaaaaa tgttggcaag aatggtcatc 30601 gttgtattta gctccatgga cttgttcaat gactggaact ctgaaacaca gagaagagct 30661 aaaagcctaa tacaacttca ggaaaaataa aagccaatga tctgaactgg ataattcacc 30721 agtcaaagga aatcattaat gcttttactt taaagcagtt gtgcaaaaat aagcacttga 30781 tttttacatg ccaaggacct gcactaattt ctttccaatg cagtagttac cacttccctc 30841 tacttccttc acgaataagt aaaagggcat gtttagagat actcttgtaa gtgtaaacta 30901 agttcatttg ggagcctcta tttgaaaata ctggtataaa aaaaaatctg tctcctgata 30961 ctaacatttg aaggaatcta cttttttaca tattggcaga gggtctgatt ctatccttag 31021 ttcttcccat tactttgatg aaccttttca aggtgatttg atccccacac ccaaatatat 31081 gattgagaga aggctcaagt tcccaggagc tccagacaga aggtacctgt tggcttgatg 31141 aagatgagga ggaaatgaac actagctag ccttaaaggg aaatgtctct gataggccta 31201 atacacagtc ctctgctaaa ggcctccctg cctctctctg ctcatccact ctactccctg 31261 gccctgggca cgcagcacac agagatcagc atttctgaca gcttctgtag atcctaccat 31321 ttaaagactt ttgtcatcca tgcagatagt ctcaggagca gacacaggta gctattcttt 31381 cacatgctag cttaacatgc atttgcttta gcacctattg ccaggcactg tgtcaggtgg 31441 agggtataca aagatgaaca agacatgatt cttctcatat acagatagat tttggaggca 31501 ttagcttagt gatgattcag gagtatccat tatttgggga agtaggtggt cattagtgac 31561 cttttacagg catttcaatg ggctaacaga gatgttagat tgtagtggaa tagaagaatg 31621 ggtaaaaagt aaatcagtga gttcagattt taggagttaa gatggcaaga ggtgagaaca 31681 aaaaaaggaa atgattgtca ttaaaggagg aggaaagacc agccaaagat tttacagtga 31741 gttaagcata caaatttatt tctaggccac atattcttag caaaacaaca tgtaaatgtt 31801 tatgtatgtc tttcctcata tctgctcatc catcagctcc atcgttaaga tttcagtttt 31861 ccaggacaaa cttactcact ttgacatatt ggactaggat ttgaccagat tccagatgat 31921 tcacaaatgg ttttcttctt cccaattaac tcagttcctt ctgagcagat gaaggtacat 31981 gcagaggtaa agctgaagct ggccagggga tggctacagt tcatgatccc caaatctggt 32041 gctgatagag gctcacactg aatcacttca atgaaaaaga aaaaaaaaaa aaagacaaaa 32101 cagtatttct gagtagagac cctcccttga gcaaaggatt tttagccaaa gctgcctgac 32161 tacattactt gtgatattgc ttccaggctt tattttcttg agaatgatgg tgggtggtga 32221 atgagagatg aaggcaagga agcattgaaa gctgtgggga gaggagtagc tactccaggc 32281 tgctgcccta gctaaggtga ccctcccctt ctgctggaag taccatgcca tatggcctct 32341 gcatcaaggg ctcttatggg atattctcag agaatctctg ccgtttcatc tgttctgata 32401 tctacccaag cattttgaaA aacatcccaa ttcactgaag caagtccaac ttccgtaaat WO 00/09525 PCT/US99/17712 EPI-109 924 32461 tccagtaggt gggttgacag ttttataatt tcaataaggg attttgatag cacttctaag 32521 aattaaacta cttaaactaa tgcatcagga gcatacttgt agaaaagtta accaaaactt 32581 cgtaagttca gatgacattg gttttctccc atatggagat aaggttggca gttaaaaatg 32641 aaaaaaaaaa aaaaacctac cttatttcaa acttgaaaag atcaagagat tgtgtttttg 32701 tttttcagtt gttattctcc taaaagttta tgcatgagga aaagtaaaag tgattttaag 32761 aataagccaa ataaaacaac caagaaagac ctccactacc ctgggaagga aactggttgg 32821 tattaagtag gacaccacat aaaacaggtg ttattgagag gagaagaacc aaaatgtaac 32881 tgaggttcaa caagacatta tttatgcaat ggcaatgaga aaaataaaaa acacagtata 32941 accatgctgt attgctataa gtcatgttac acactgggag atggcttcag gggtatttgg 33001 tttttacttt ttgtttggga ggtttttcaa aaaaatttag ttagaataag tcctttgaga 33061 aacatcacag taggttaaac aaagttaggt taaattaggc tcctaagttt gacttctcag 33121 caaacttcta ctgaatgttc tgactgtaag cccaggattg catgacaaaa cctctagtct 33181 gaagttactc accttgacag gttggttctg gagatgacca gtttccaaat ggtccacagg 33241 tggtttcttc aatcccagtt aagtttgttc cttcagagca gctgaaggca cactgtgagc 33301 tgaagctgaa gtttcccaaa gggtgagtac agtccatggt acccagctct ggggcctcca 33361 aaggctcaca ctgaatcact tcaataggga aagaaacagt atggggaaga gttaagagga 33421 actgacgcct ggatttgaat cctagccctg ccacttgata accatgtgcc tttaaacaag 33481 gttacttgaa ccctccaact tcagtttctt catctatata agaggaataa tgaaattgtg 33541 ttatctttat caaattgata tggaaactaa atgtaattca attagcataa gtcaaggacc 33601 ttagaacaaa gcctgactca tcagaaattc taagtaaaca ttagctagtc ttcatattat 33661 tatcttcagc attatctgta gtgagaatcc ttaaagccaa ataggtgtaa ctgggaatga 33721 ccagcttagt cgggaaataa ctatcacatc agagcccctg agtctactag agtattggga 33781 gcaagatgtt cagagaaaga gtgggtctcc ataataagcc ttctttgcaa ggagagaata 33841 taaaagtcta ggaagcattt tgacctcaat tctgtcttct attctagctc agttccagaa 33901 ttttaactct tttgattttg acaaccctct ccagaaactg tatctatttc cctgttctga 33961 ttggtggtac aataggtaaa tttaagactt ggaaatcaaa gttttcacat tttagaccct 34021 gccatgccat ttagtaaaca gtacaacttt catgtcttat tcctcatctg tcaaatttaa 34081 gccattattg ctaccttgct ctagagactt caaggaagaa tggactcaag gaatcagaag 34141 aatttttgta tttggaaact atatgagatg agattaggga gaaacatggg aactaagaga 34201 aaatgttatc ttttttcatt gatttaaaga gtatctatta tatatcaagc attactctgg 34261 ggcttgaaga gcttagattt caccctgtag gacaaaatgg taggtagaaa ttaatgggtg 34321 gattgtcatg tatgtgtgat gtgttttaat tgcttttaat tgatcagtct ccctgtagta 34381 tgaataatgt atttgagggg agctaattta aaattgtgga actcatctaa taaactattg 34441 caagaatcta gaagaaagat aatgacggca atggtagtag agttgacaag tggaagacaa 34501 attagaaaaa cactaagttg taaaaattgg tagaatgtta ccctgcataa atgttggggg 34561 agttaagaga gtctcatacc agggtgccca tgtaaatggt gattccacat actgagataa 34621 gaaatacgaa gagaaaagct gactgggaac aattggtttt atagtctttt aaacatccca 34681 aaggacatcc ttagcatatt tgagttcaga gctggagata ggcttatcag tccaaagatc 34741 acatagattt gtgagtccgc aaaagtcagt aagtttgacc aaaggataca tgtagattag 34801 agtcagaaga gcaatataca aaagacaaaa gctgagaaat tatagtagtt tatggtcctg 34861 gataagtgct catgaaggat ctcaggagaa atgatcacag gtagaaagaa tgagaaaaga 34921 gtgatatgag agaaaccaag acaaagaaaa gtaaaatgtt aaaaatgagt gaaataggca 34981 taccaataat taaaaatgag taaaataggc ataccaataa cataagggtt aaaaaataga 35041 gttcaaaaat ggggtgaggg taaagtatta ggaaggagtc atggcccagg gatcaagtga 35101 aatgagttag atctatagat ctatttcagt tggttgacat ttaaatgtat tttggtttta 35161 attctttatt gtttacaaac attgcttttt taaaaaatta aattgtccaa ttcaattcag 35221 gctcacaagc aagtgcctca tatatacagg cattttgtgg atcccaaaga tgcaatgata 35281 aataggacac ttactgatct caagaagttt tcagtaccag aggagacgga caagtgaaca 35341 gatgacttca acataagtgg gagaaatgag gaagaaatat gtggagctat cagaactaag 35401 aaagcttcct agaagaaact gtctttgaac aatgtcttaa agatgacatg ttttttggcc 35461 atgtgcaaaa tgagagagaa ggccaccagc aaagtcagtg tgctacagag cacatgtgtt 35521 aagtgtggag aactgcaaga aggaaaggaa ctactagaag gaaaaagcaa gatactttct 35581 gggtaactca gcctcctaat gataaatggc atagtttctt ccagacctta gagttctaat 35641 taatctaaca agctcattag atcgtgagct tcttgagagc gggaatctac catgctaatt 35701 ccttatggta accctgacag cttttatccc aacactgtgc ttcttgtggt actcaaaaag 35761 acttgttgag aagtgagtcg aaacttcatg ctgacttatg aaatctttac ggaaaggtaa 35821 caatattgtg aaagcagagc tttctgatca aaacttccca tttctcagag tggctagtat 35881 cattttgttc caaccagctt catgataagc tataatgatt cctgtgactt tacctaagaa 35941 gaagcaaaga aaggaaagag acttaccaaa ctgacactgg ggcccatagt accccacatc 36001 acagttgcag gtgtaattat tgatgatttc tacacattct ccatggccac tgcatgacca 36061 gggctggcaa gaagctttaa ggaggtcaga aaaaaaatat tttaatgtga ttacatttta 36121 gtactcaaag tcatttcttt agacatagat aaccttttgt ctgagatgat ttaaataatc 36181 aggaaaggtt tatttgtaaa ttcatagcat aaaaatcata tgctaaaatt tttacgtata 36241 aaatacacta agcatatagt cataggcatt tatttgcttt tggaatgaaa ttaccaatac 36301 taatattctg taacacttat aggaaactta gtggcatacc ttgaaactct tgaaattact 36361 tgtttttaat gagtgagaag gttaaatgat gacctgacct caatcatttc tgcatgcaat 36421 tatttcttgg caatcccttt ctttatagaa atcaaagatt aaaaagtcca aatttgctaa 36481 aacggtagag tccaatttat aagagaccaa attaactatg gttcattatt aaaacatcac 36541 ttggaaaatg ctggctgttt tggaattgta gaagatttta cagaaatatt catacaccaa 36601 agatagtgca atttttatat aaaattatat aaggttagac caagaaggaa gcacgcagca 36661 ccacactctc tacttcacaa tgtgaaaact gaggtgatgt gagcctaagt ttccaactgg 36721 ccccagctgt cagcttctcc tcccctgcct tattatcaaa ggcactgatt gtctagctct 36781 tcctctgtac ttcctacgta gatctatcat tttgatgtaa cttgatttag gggtatagct 36841 tttgtgcaca gggacaaatc ttacacacca aaaattctta ggagtgacac gatgcaagat 36901 tatatagagg gctagatgta ttttagaatg aaccagaagc tgttctcatc cccccacctt WO 00/09525 PCTUS99/17712 EPI-109 925 36961 tccatggggt aaatctgagt attctcttaa ccgtggccct tcctgagtct gaggcagcat 37021 agccgtcttg tcactcccta cctgtgtaac agagggctgc ctttagtttg tggcaggcgt 37081 catcgttcca tttgcctgca tctttgtttc tcttgatata gatctccacg cagtcctcct 37141 tgttcttctt gttgttgggc tcaccatctc cccagttctc tgcttcttca gtaagagatt 37201 tgttggttcc cacccacgtc catattcctc ctatcttccg gattcctatc cagtagtaag 37261 aacgactgaa aggcagagtc ttctccagat actcaatttc cgccttgttt tgtatggcaa 37321 ctaaatctgt gtaattgtct cggcagaatc ttctagccct ttgccagttc atgggttttt 37381 cagaataatg gtaagtccag cagtcggttc catgatgtgc caggaaatct gcaagacatc 37441 agtgtgacct atgcagactt acataatgtt acagctaaaa agaacctagc actactccag 37501 gctgagctag acacttagag atgaggaaac agagcctaag agtgtatgtg accatctcag 37561 gatcacagaa tagttgtttg cagatttgaa gtagaaccta gaccttctgg cttgaatata 37621 agatgctttt atctaaggtt ctatttgaaa caaatttagt ggttttctag gtttattttc 37681 ttattaattt ttttctcaaa attatttcag gtgaaattta accaacatat tttagacatt 37741 catatttctt tttctttgta gctgttaatg atttacaact aattaccgtg taatatcata 37801 taactataca atttacgtat actttttaat cctggaatca tttcttgaag gccaacacat 37861 atgtacctat gggagaagca taataaggac aggaagaaca gtgacatact tttaagtaac 37921 ctcttttaca taaaaaacat tttattttac cataggaaga actgcttctg gaaaagccca 37981 atataccact caactcttat atatctaact gtataatttt taaaaagaac aatttacaaa 38041 gccaaatggt ataggattat gaaattcatt agatcatgtt ctatacacaa agagactcaa 38101 ctgatgatgt ttaataaaca tatggaccca tcaaatatga gggctttgaa gatatctaat 38161 taaacacata attacacaat gacttcataa taatatatgg cattctaagc atggtatgat 38221 ctacatgaat cactatttaa tacagtaaag aaacagatat aattgatggt aaagagcatc 38281 ataaaataaa cattttgaac agagttttga atgagcattc cactagaatg caagttctaa 38341 gagggaaaaa actgttgtgt ccactgctgt atccttagtg cctagcataa atttcacaca 38401 ttgtagggac tcagaaaata cctgttgtat gaaaagagca ctaagtttct atgtgacaca 38461 gtgcagacat ggcataagga atgtgtgaac gggagagtta gcatgtttgc ttggctagag 38521 ctgaaaatcc aggctaggga gaaagaagac attagtttac ttaggaaatg aaaaaccaag 38581 ttcaaagcta ttgctggaga gtcttcaaga atcagatata aaatttgtca caacaatggg 38641 agaaggacca aaaaatgata aacccccgtc ccttaataag ctcgtattgt aattgtagaa 38701 atgacattaa tgtacactga actatgaata aaaaatagaa aatgaggtgc taaatatttg 38761 gtacagattg taagtacctt aacagagatt tcttaattaa cattattcct ttataattga 38821 gggattttgt ggggttattg ggatttgaac tctacagcat gggctattat aggttaaaaa 38881 tagtgttcag qagtttctqg ggaagaacta aaggtaagaa gaaaagagat gtttacagaa 38941 gggatagaat taacagctct gtgaaataat tttcccttag actatgtata actagtggat 39001 atttaagaaa aatgaatata agtaaaatag acttagcgat atataaatat cataacatac 39061 cacaacagag cattgtccac ccccacaact tgaagatgtt ccataagtcc ctctgggtgc 39121 tctgacattt ccatggaaat atctgcaaat gaaatacaaa attatattta gatgtatact 39181 cttaaaccac acatttatag cctttgaggt ggtgcttaca actttcttaa taatcagaat 39241 aaaacacata tgtctactaa ccctgtctga ggtaacaggt ttctcagaca tagatgaaaa 39301 attacttcaa atttacatca gaactgatgc acagttttgt tttgttctat tttattttta 39361 cgctttagtc tcaagttgct aatcggtact gccctgaatt ttttctatgg tttggtaatt 39421 tttatacctg cttttctgct gagctattag ataaaactat ttaatattta ctatgtatat 39481 tttttaaagt attgttgctg cttaattaac tattgatgct tatatttaat gttatagcct 39541 cactcttgat cataatgggt caatgcctca aatacctaaa aaaaaaaaaa attagatagc 39601 cagacaccag gaaagaaaag tatttctttt tttaataaaa agaaatacct ttttgagcaa 39661 ctgaaatgac aaagtcacaa atttcctgca caccttaaaa tatacttaat gtaaatgacg 39721 agttaatggg tgcagcacac caacatggca catgtataca tgtgtgacaa acctgtatgt 39781 tgtgcacatg taccctagaa cttaaagtat aattttaaaa aaattctatc ttccaaagca 39841 tatcacttct caggtagaca cagtgtttat tgcaaaagat ctgatttcaa tagtatttct 39901 tcaagagtct ccccagagac aaagtcaaga agaggaaatc agcatatctg agaagaaaga 39961 tttcaggatc actttttttg agggtctgag aaaatgttta gtttctatat tatttaaaac 40021 cagaattgaa atggggtgat tcctatcctt gccacctgcc tctacaaccc caagagtttc 40081 tatctgagca tctaaacgtc ttttaggctg aaaggctcac catggctttg cttggtcctt 40141 ctctagttct tctgcagccc attgagcctc ttgacttagc acaagggtct caggtccttg 40201 cccaaaggga gtgtgctgtg ctgcaggtag actgcactga atgtcaacag aaagccttgc 40261 tttctttcat ttctctaacc cagtctcaca tcctcctcct cctccccttt tccctcccct 40321 tcctcctgca cttctctttc ctctttcccc acccctttcc tagactggcc tctattgcct 40381 cccactgaga caaaaatgaa ctgctgatca gaaagtaatg tgactagatt ctctcttcct 40441 tccctccttt ctatccttcc ttccattctc ctatgcatct ttccttaccc tcctcctcct 40501 tcactcattg ttgttgctgt tcttcttcct cttctttttc ctcctgctcc tcttcttcta 40561 cttgttcttg ttcttgtttt tgtttggttc ttgttctcct cttcctcctt ctctctctcc 40621 tcctcctcct tcttttcca, caccctcccc tatctttttc ataaatgcta aactaactct 40681 tggctacctg tggtaaatgg cccttggaaa ttgcaaatac tacaaatcaa aactgcattt 40741 cagacatatt tatgatgttt gcaaaacttc agtagagcta agcagtggac ttgactcgtt 40801 tcggttcctt cacctccgtc tttccttgct caccacctag tggacgtcct tgttagtggc 40861. acttcctgaa gttaacccct gaagagagcc catgctctct agcttttcac cgtgtaggtt 40921 tgggagccta caagtacctt taatattctt ggactataaa atgagatggt tttataagac 40981 tgcatgtgaa attaggaccc atatgatgaa ggacaataaa aaggaagacc cactgatgtg 41041 agtcaatgag tcaaatgcaa atcagatttg catttttagg aaaataataa taacaacaac 41101 aaaaactctg aagctcagcg ccccatattt attatattgt ttaatcttta taacagctct 41161 ctgctataga tatgattatt atccccattc taaagagtct caaagaggtt aagaaacaaa 41221 ttcaaaaact agcgaaagac aagaaataac taagatcaga gcagaaccat aggaggtaga 41281 gacacgaaaa agccttcaaa aaatcaataa atccaggagc tgcattttga aaagattaac 41341 aaaatagatg gaccactagc tagactaata agaaagaaga atcaatagac acaataaaaa 41401 atggtaaagg ggatattacc actgatcccg tagaaataca aactaccatc agagattact WO 00/09525 PCTIUS99/17712 EPI-109 926 41461 ataaacatct ttacacaaat aaactagaaa atctagaaga aatggataaa ttcctggaca 41521 catacaccct cccaagacta aaccaggaag aagtcaaatc cctgaataga ctaataacaa 41581 gttctgaaat taaggcagca attaatagcc taccaactaa aaaaagccca ggaccagatg 41641 gattcacagc caaattctac cagaggtaca aagaggtgct ggtaccattc cttctgaaac 41701 tattccagag aatagaaaaa gaggaactcc tccctcactc attttatgag gccagcatca 41761 tcctgatact aaaacctggc agagacacaa caaaaaaaga aaatttcagg ccaatatccc 41821 tgatgaacat cattgcgaaa atactcaata aaatacggca aactgaatcc agcagcacat 41881 caaaaagctt atcaaccaca atcaagttgg cttcatccct ggaatgcaag gctggttcaa 41941 catacacaaa tcaataaaca gaatccatta cgtaaacaga accaatcaca aaaaccacgt 42001 gattatctca atagatgcag aaaaggcctt ggataaaatt caacacccct tcatgctaaa 42061 aactctcaat aaactaggta ttgatggaac gtatctcaaa ataataagag ctatttatga 42121 caaacccaca gccaatagca tactgaatgg gcaaaaactg aaagcgttcc ctttaaaaac 42181 tggcacaaga caagtatgcc tctctcacca ctcctgttca acatagtatt ggaagttctg 42241 gccagggcaa tcaggcaaga gaaagaaata aagtgtattc aaatagaaga gaggaagtca 42301 aattgtgtct gtttgcagat gacatgattg tatatttaga aaatcccatt gtctcagccc 42361 aaaatctcct taaactgatc agcaacttca gcaaagtctc aggttacaaa atcaatgtga 42421 aaaaatcaca agaattccta tacagcaata atagacaaac agagagccaa atcatgagtg 42481 aactcccatt cacgattgct acaaagagaa taaaatacct aggaatccaa cttacaagga 42541 atgtgaagga cctattcaag gagaactaca aaccactgct caaggaaata agagaggaca 42601 caaatgaatg gaaaaacatt ccatgctcat gggtaggaag aatcaatatc atgaaaatga 42661 ccatactgcc caaggtaatt tatagattca gtgctatccc catcaagcta ctactgactt 42721 ttttcacaga attagaaaaa aactacttta aatttcatat ggaaccaaaa aagagcttgt 42781 atagccaaga caatcctaag caaaaagaac aaagctggag gcatcatgct acctgacttc 42841 aaactatact acaaggctat agtaaccaaa acagcatggt gctggtacaa aaacagatat 42901 atggaccaac ggaacagaac agaggcatca gaaataacac cacacatcta caaccatctg 42961 atctttgaca aagctgacaa aaagaagcaa ttgggaaagg attccccatt taataaatga 43021 tgttgggaaa actggctagc catatgcaga aaactgaaac tggatccctt ccttacacct 43081 tatataaaaa ttaactcaag atggattaaa gacttaaatg gaagacctaa aaccataaaa 43141 attctaggag aaaacctagg caataccatt caggacgtag gtatgggcaa agacttcatg 43201 actaaaacac caaaagcaac agcaacaaaa gccaaaattg acaaatggga tctaattaaa 43261 ctaaagagct tctgcacagt agaaaaaaaa aaactatcat caaagtgaac aggaaaccta 43321 cagaatggga gaaaattttt gcaatctatt cacctgacaa agggctaata tccaaaatct 43381 acaagaaact taaacaaatt tacaagaaaa aacaaacaac accatcaaaa agtgagtgaa 43441 ggatatgaac agatgcttct caaaagaaga agtttatgca gtcaacaaac atatgaaaaa 43501 aagctcatca tcactggtca ttagagaaat gcaaatcaaa accacaatga gatgccatct 43561 catgccagtt agaatggcga ttattaaaaa gtcaggaaac aacagatgct ggagaggatg 43621 tggagaaata agaatgcttt ttacagtgtt ggtggaagtg taaattagtt caatcattgt 43681 ggaagacaat gtggcgattt ctcaaggatc tataactaga aaaaccattt gacccagcaa 43741 tcccattact gggtatatac ccaaaggatt ataaatcatt ctacgataaa gacacatgca 43801 cacttatgtt tattgaggca ctattcacaa cagcaaagag ttggaaccaa cccaaatgcc 43861 caccaatgat aaactggata aagatgatgt ggcacatata catcatggaa tactatacag 43921 ccataaaaaa ggatgagttc atgtcctttg cagggacatg gatgaagctg gaaaccgtca 43981 ttctcagcaa actaacactg gaacagaaaa ccaaacatta cccattctca ctcataagtg 44041 ggagttgaac aatgagaaca catggacaca gggaggggaa catcacacac tggggcatgt 44101 caggggatgt ggggctaggg gaggaacagc attaggagaa atacctaatg tagatgacag 44161 gttgatgaat gcagcaaacc accatggcac atgtatacct atgtaacaaa cctgcacgtt 44221 ctgctcatgt atcccagaaa ttaaagtata atttaaaaaa agtttaaaaa aagaaagttg 44281 ccttagtcac ataactagta agagacatgg ttgggaattt gaacagaggc caatcagttc 44341 caaatccatg ctcttgatca ttaagctgaa cttatggcag gaacttggaa gacatggtaa 44401 aatggggaaa aacgtggagc cagggagact tgtgaaagtg ccagtgctcc cactataccc 44461 tgaaagaagt atctagactt acttttttct aagtcctctc ctctaattct ctcaatctct 44521 ctctctcttt ctctaagaga tgggaatgct gctctgtcac tcaggctaga gtgcagtggt 44581 gcgatcatag ctcattgcac tcaaggaatc ctagggtcta gtgccccttc tccctcagcc 44641 tcccatgtag ctaagactac aggcacatgc cccaaccctc gactaatttt tttatttttt 44701 atttttgtag agacaggatc tcactatgtt gctcaggctg taattctgtc ttgaagcttg 44761 tccaatcagg ctttcagcca caccaattcc ctgagactgc tctcaccaag gtcctacact 44821 tcactaacac aaacagccta ttctccatcc tcatcttact tcaccaggga gctcctggtt 44881 ttcctcctac ttcactggct atttcttctg tatcatgtgt tgattctccc tcatctccc 44941 aacctccaaa cccttggagt actccagaga tcaccgcttt gctcttctgt gtctaacctc 45001 actaacttgg tggtccaatt cacactcttg actttgaata ccatttaaat gcgaacgaat 45061 tctaaattct gtacaaccag aaccattctc ctgtagccaa atgcctactc aacatctcca 45121 tccccaaaca aatttagttg ttcaataagc ctctcatatt ttacatatcc caaactgaac 45181 ttctgaattt ctcctccaat ctgtagggct cttcccacag cctttccatc tcagtggatt 45241 ataactccat ccttccagtt actcagacca aaacttttgg agttaactga gacacctctc 45301 ttttttttca caagtcatat ccaatgtgtc aacaaatttt ggtagtggaa atattgcggg 45361. attttttaag aaatcagaga gaccgatggg gttcaggagg atatttatta tttaggtgca 45421 ctggccaagt cagattaaca tccaaaggac tgagccctga acaaagagtt aagttacctt 45481 ttaagcattt tgtggggtgg gagagagggg tatctgtgca gggggaagca tactacagaa 45541 gtgagaaata aagacagtta ttcaattaat tgagacatgc attacatcat ttcttacttt 45601 tcaagaagaa acatgttttg cgacttgagt ttatctgtct agtgaccttg cagctgcaca 45661 gctagagaaa cagggtcttc acaatgcctg ggaaaggagg agaggtaagt ctcactagcc 45721 acagaaaaac aggcagttaa tttttaaagg gctccagctc tttctctttc tcagggggag 45781 ttgggttttg ttacatacaa ctgagtttcc gcttacacat tatttaattt cttttaattc 45841 ctgttccaaa agaagccaga tacaaaaggt tacatgttgt ctgattccat ttatatgaaa 45901 catatagaag aggtaaatcc atagagacag aaagtagatt agaggttccc aggggctgag WO 00/09525 PCT/US99/17712 EPI-109 927 45961 gaagaaatgg ggactaactg cttatagggt acagagtttt cttctgataa aaatattttg 46021 gaactagata gacattttgt taggccattc ttgcattgtt ataaagaatt acctgagact 46081 tggtaattta taaagaaaag atgtttaatt ggcttacact tctgcaagct ttacaggaag 46141 catggtgccg atatctgctc agcttctggt aaggcctcag gaagcttaca atcatggcag 46201 aaggtgaaag gggagcaggc atatcacata gcaaaagcag gagcaagaga gggatgtggg 46261 gaggtgacag tcacttttaa acagccagat cttgtgagaa ctcattcact atcatgaaga 46321 cagtaccaag aggatggtac taaatcattc atgagaaacc ccaccctcat gatcaaatca 46381 cctcccacca ggccccacct ccaacactgg ggattacaat ttgacatgag atttgagtga 46441 gaacacggat ccaaaccata tcagagatgg tggttataca atgcgataaa cgtcactgga 46501 ttgtacactt taagatggtt gttttatgtt gtgtgaactt cacctcaata aaaaaaaata 46561 tttaatgtac attcagccaa aagaagattt ggaataqgaa aggtcatgga gatatattaa 46621 cagccatttg atgggtggta aggaaaagag tggttattag actgttttgt ggccctcaaa 46681 aggtagaact agatcgagtt ggtgagcatt ataaaaccat cacaaaaccc tggagagagg 46741 acccagtgct gaagaaccgt ttgcctgcca tgagacatga gggaagtacc agtgaatgcc 46801 attgaaagca gcatccctgg gtccaaggga tggtcaaagg accactaccc aacccttccc 46861 tagcctacgc ctccattaca gatgaccgca agatttattt gctcattgct gccaaccaag 46921 gctgcactca ctgcagttgc tatcagttta tcatgggtaa aaggaatgtg cagtagagaa 46981 ctaactaact gcccacctac ctccacaatc ctatcaggac aaatcaccat ggctcacatt 47041 tccttacatt tggcatgtaa gcccctctta ctgtctgtca tctatctcct acacagttca 47101 cctaaactgt tctctcctga cccaaccttg attttcatcc caaatgcttc cttgccatct 47161 ctgggattcc tgtcttcacc atcaccaaac tcccctcaat cttccagttt cctgttcaaa 47221 cttttctcct acctccttgc tttgtcatta gcccgactgc ctccctagga catcacttcc 47281 cctgcagatc tctcaagatg acaatattta ttctccacac agcacatact tcagggttgg 47341 aaggcagggg caatcttctc ctttataatg agtgcctctt atatatgttt attcatctgc 47401 cctcttgtaa aacacacaca cacacacaca caaagaagaa ataaaataac tctgcttctt 47461 tgaagcttgt gacactgaga taaaccatct cactgtcctc attgtagtga cctctcaact 47521 cctcatgcaa gattggcttt ggcacctagt tcctgatctt cctttccctg taagcacttc 47581 tcatagtctt acgggacttc accatccatg gcacaaccaa taccacagcc cagatcctca 47641 gctctccaat gacattttcc tccactagac ttgagctacc tccttcccta ggcacagcct 47701 caacctcgac aacacctaag actgtaccgt ctctaaagtc acatgttcaa acacttcact 47761 ctttaaccac tgtctcctat tcttgcaagt gtattgctca agtatctcat tgcaatgctt 47821 tttacttcta cctcattgaa cctccaggcc attaaacatt tccttatttc taaccatcag 47881 gtttctcctt acttgtttgt ttgtttattt gtttcttttt tttttttttt tttgagacag 47941 ggtctcactc tgttgcccag gctggagtgc agtggtatga tctcggctca ctgcagcctc 48001 catctccctg gttcaagtga ttctcatgtc tcagcctccc gagtagctgg gactacaggt 48061 gcatgccact acgcctggct aagattttgt atttttatta gagaaggggt tttgccatgt 48121 tggccaagct ggtctcgaac tcctaacctc aggtgatcca cctgcctcag cctcccaaag 48181 tgctgagatt ataggcatga gccactatgc cccacctggt ttctccttat ttatttcaag 48241 tctatgctgc actattaaaa ctgccttgac aaaaattata atagtgagaa aattatgaca 48301 gtgaaagaga tctgaaataa tcaaccccca tcttgccttt accttccaga ctgcccttaa 48361 taattcctga gcttgggcca agctatcttt ggcagaaatt tagtttatag tttaaatgat 48421 aatagccctt ctccaaaact aaactgcctt tgtaaaacta ataaaagacc accaatgaaa 48481 ggttaggagg atgagaggag cctgaattct gctaaggtgt agatgtaaac aattaccaac 48541 tgttattccg gaggtcacaa gatttgcaac atcgccaatt actcctgcag ataacagcac 48601 tatcatagaa tctgattggc cttttgagat gtcttttcag attcttacat ttcaactggt 48661 ggctctacct ggacccatca acaagtcctg tggctccacc cagaagcaga cttaacatgc 48721 acaaggacca ttttccacac cgctatgatt gcatcccaac caatcagcag caaccattcc 48781 tctgcctgcc aaattatcct tgaaaaatct tagccttaga attttggggg aggctgattt 48841 cagtaataac aaaaccccgg tctcccattt ggctggctct gcatgaatta aattctttct 48901 ctattgcagt tcccatcttg ataaatcacc tttatctggg cagcaaacaa aaggaaccca 48961 ttggacagtt acactgttgg cagatatatc ttgcttccaa aattggattt ttgtttaatg 49021 aatttattct gttttcttga tatttacaac tgtgaatgtt gtgtctgaat tctctttatt 49081 tcttgttgaa aagaactata ttgctacagc cagtacatac agatggatag ctaattactc 49141 aacacggggg gatgtgacca tcaccgcact gtgcaaatga atgttaccca ttgtccactt 49201 ttcccaaact acatagtgtt atatggtata tgacccaatc aacggtggca aagctccaga 49261 aataccacat agacatcagg gacactttaa actaatcagc ctatagtcct ttttcagtaa 49321 tttccaaacc tggttgtgca tccaaatcac ttggtaacat taaaaaaaca aaaaaatata 49381 cacgcaacat tcgctcccaa tcctactgaa tcagaatatt ttgggttggt tcaggaacat 49441 tcaggagttt ttcagggtcc aaggtttata taatttgagg tctctctttg agaaaaggaa 49501 cgtaaaagcg tcttgctttt atagatctta caaagatgta ttaccatgta aacacattcc 49561 taggacccag gcccttgtaa tttaaaggtt tatctaagta atgggccctg aagcttaatt 49621 ttcattatct tcagggcaaa ttacctgtgg gttagggttt aggaatatat ctctctgtgt 49681 atgtgtgtgc acattagcat gtacgcttgt gtggattttt tttttttttt tttttttttc 49741 tgagacagag tctcgctctg tcgccaggct ggagtgcagt ggcgtgatct ctgctcactg 49801 caaactccgc ctcccaggct caagcgattc ttctgcctca gcctcttgag tagctgggac 49861 tataggcacg caccactatg cccagctaat ttttgtattt ttagtagagt tggggtttcg 49921 ccatgttggc caggatggtc ttgatctctt gacctcgtga tccacccgcc tccacctccc 49981 aaagtgctgg gattacaggc gtgagtcacc atgcccagca cttgtgtgga tgttttaagc 50041 tcccaggtga gtgaatacaa aactagatct ttcccttctg tagcatctgt actgtttact 50101 ctatgcatct caatattttt tcttttagta tctttccttt ttctctctta ttacttcctc 50161 ttgtgctatt tttacacctc cttttttaaa aaattttttc ccttttattt ctattgacct 50221 ttagccctca caatgattcc tacaagcccc atttctgtaa atggggattg aaataattgc 50281 tggacttttg agagatagat atattaaatt gcaaactggc agtagtgggg gcagttgata 50341 cataactagg ttttaaagtc tagccttctg agaccactca ttccatttgt gaaaagtgat 50401 tctacttctt attatgagcc aaaatatgca ttcattcacc catgcattga tttattcatt WO 00/09525 PCT/US99/17712 EPI-109 928 50461 caataaatat ttgttggatg tccactctgt atcaggaatg tgctaggttc tgggaataca 50521 gcaatgaaca aggtaatttt tccctacccc taaggaactt agagtttagt ggggaagaca 50581 gacattaaac aaacaattgt gcaagtaata atctataatt atttattaca attaaaggaa 50641 ggaagagaca tatggattat gagggcatta aagaggagac ctagtgtaag tagccagttc 50701 tcgtgaaggg acatgtatta gttggagttc tccagagaaa cagaaccaat ggtgtgtgtg 50761 tgtgtgtgtg cgtgtgtgcg tgtgtgtgtt ggggtgtggg ggtgtggtat tttttataga 50821 aattgtctca cacaattatg gaagctgaga agtcccatgg cctgctgtct acgagctgag 50881 aaccaggaaa gccagtggaa tacttcaaag tccaaaggcc ctggaaccaa gagtgccagt 50941 gttggaaggc aggagaagat gggtgtccca gcttaaaaaq acagtgaatt cactcttttt 51001 gctctacata gggcctcaat gggttggatc atggccaccc acattggtga aggcaatcct 51061 cttagtctac caattaaata ctaatctctt tggaaatact ctcacagaca cactgagaaa 51121 taatgtttta tcagggtgat agaaatcttc tggagttaaa caatggtgat agctgtacaa 51181 tcacatacat ttttaaaggg tgcgttttat ggaaagtgag ttttatctaa ataaaatttc 51241 taagaaagag acttaacaca gagataaaca taagcacatt tattgtcaac ctttatagtg 51301 ttatgtcaaa taggtctgac ataagcttaa ataaatatat actttaaaaa ttataaaata 51361 ttttaagtta taatttaaaa ttctcaataa aactcaaaca caaaccacac tggtatttca 51421 cacagctaat ttctaatgca gtttacataa atatttacaa cacttaaaca atttcaaaga 51481 aaataacact gtattccata catagcctga tcacagtagt tgttctctct tatttcccag 51541 agtttttctg cccctttaaa agaacctctg ctgttctgat ccttatcaca tctctgtttt 51601 gactgttggc tttgttgttg ccagtgttca gccagaactt ctctgaaact tttttttcaa 51661 cacatgctaa gttaatggaa gtgtaggaga gttttgattc tcacactcct caaggctaga 51721 gcagctttgg caattactga ctgagaattt ttcattgcca gtgatcaact gaaaactgga 51781 gattcctttg gaattgttaa atctgcttat aaataaacat aaatgcttgc tcacacaggc 51841 attcctctct tccagagcac cctaacatac agaagaaaac aaatagggaa taactattag 51901 acatcttcat tcgttaaaaa tctaccagat gactctttta catggtgagt ttctattgtg 51961 aatttaaaat cttccataat atacaagaat tatgtttaca tatcatatct gacaaacatc 52021 tttgtaggaa tgcaaagcac atccatcttt ctgtattctt ttccaacaaa gacattcata 52081 aaattatacc tttgtgtgtt tgcatttatg cttttattag ttcaaaacgt ttggcctcat 52141 ggaagttttt catcgtggaa accacatatt tctgaaaaaa tatctgacaa tatacaaacc 52201 ttccattcag tttttactct ccaattctac catgttttca aaaaacaact gtagtaaaaa 52261 cactcagaac tttattctgg ttaacatcat gccttgctag gggacaatag tttccctttt 52321 tgaaataaat ttaaaacaga tgtaacataa tttgttaata aacaatgagg gggtaatcta 52381 gaataagtaa cttttaccat atcatagttg acagcattta caagtttttt aagtccctac 52441 cacacttgta ttgaatgaag aagtatggaa gattataata tattcaatgc aagtaaaaat 52501 atcacaatcc ttaagaactc tttaagaagc actgaatccc atagggatga aagtgattaa 52561 attgtgcata gtaaccctcg cacagagcat tcagtaggat ttgcaccatt aacaaccctc 52621 catgcatttg cctgtgggca ttcaacatct gtcatttttt taagttataa tatttttagt 52681 catttttttc ctctaaactc tggataatta ttattcattc ttatgacagc aactgtgtaa 52741 tcagctgtcg aaacactgtg aagggcaaaa gaaagaaagc cacaaaatat tgtgtttctg 52801 tgccaagatt ttacagcgag caagggagag ttagaaaagg aattctgaga tttcagagtc 52861 ttggtctctt cacctttgct tggaagaaaa tatcctttcc cttcattagc caacactttc 52921 ttgatcctga gagtaggaaa gggaacactg agtcttttca gttgaaggcc gtccttgcct 52981 gctggacttt gatctattga agtggtgatg ggtgttgcgg tttcagccat aaaggcatct 53041 ggcatagtag gcaagaaggg ccagagaccc gaggagagtt atctgtctct gttaacttca 53101 gtgtatccct ctagttcccc agatgcacct gtttctgtaa atataaacat gcatgtcatc 53161 agaacactta atattctgca tactgatcat gacaacaaaa tgtaccttct aacacagaca 53221 ctctcactag gatagaccat gtaggaacat cgaattctat tcagttagga cagtgatgat 53281 gtctacatat tatacctctg tcaaaaccta cagaatatac aacacagcac agagtgaatt 53341 ctaatgtagc ctgtggacat taatgaataa taatgtatca atattggccc atcagttgta 53401 acactaatat aagatgttaa taacaggggg aattgaaggg gtggtgggga gatatgttgg 53461 aactctttgt gctttctgct caatttttct gtaaacttaa aaccgcacac acaaaaaaag 53521 ttattttaat tttttaaaaa gtattcagag ggacttgacc tttccaaatt ctctcaaagc 53581 aggtcggagt agttaagaac acaaatttta gaaccagact gccagagttt gaatcctggc 53641 tacaccactt actagctttg agatttcaga caatttactt aacttctctg tctcattttc 53701 ttcatctgtg tgataagaaa taaagtaaca ggccaggccc agtggctcac gcctgtaatc 53761 ccagcacttt gagaggccaa ggcgggtgga tcaggagttc aagatcagcc tggccaacat 53821 gacgaaaaaa tacaaaatct ctactaaaaa tacaaaaatt agctgggtgt ggtggcaggc 53881 acctgtaatc ccagctactc aggaggctga ggcaggagaa ttgcttgaac gcaggaggtg 53941 gaggttgcag tgagccaaga tcatgccact gcactccagt ctaggcaaca gaatgagact 54001 ccatctcaaa attaaaaaaa aaaaaagtaa aaagaaaaga taagaaatat agtaccagcc 54061 cctatctcag agttcctagc ttagaaaaat tcccagaata taataagtgc aatgtaaggg 54121 tcagctatct tcattattat tatctatcat aaatgaaatt acacaataaa gctagatccg 54181 tttctttcct ctccttctac aaaaaataaa gcaactttcc agaacaatac ccaggtgatg 54241 atttctcccc tgctccctcc ctaagatatt ggcaagtttg gagggttcaa ggagaaacag 54301 agcatgtaga gaagatacct ctctcataac catttgtgat ttacaagtct tacctgattc 54361 ttttgaactt aaaggatgta agaaggcttt tggtagcttc catctgattc aaggctttgg 54421 cagctgctgt ggaatacatg agaacactag gtaaagcact gtcttccaac atgaagagag 54481 aaaaatatgt ggaatqttca atggcatgct ttgtataaga atgcaactta cctggcagga 54541 acaaatttct ttgctgcaaa agaaaagaca aacaaccatt aattcagact aaatgacttt 54601 taaggatata ttaaatccag atacaatatg acttaattca tcaagtgttg caaactcgat 54661 gcttcagggc ctctgtaata atcagagcac aagcatggct ctgtggcatc tagggtaaaa 54721 tgcaaagtgc acagccatcc aaagggcata gcagcttcct aatgccagca aatagctacg 54781 gggtcatctt gcccaattca gctcccaatt tttcatgaga agtccaaagt cttaatttaa 54841 atgtgagatt tcctattttg taaacgtcag aacttaactc aaaaatgttt taagtactct 54901 taaacatgta agccaaacaa accatgagtg tagtcagatg tgcttccata ttccttatga WO 00/09525 PCT/US99/17712 EPI-109 929 54961 gagactctca aatttaaqcc tgtactccaa ataaatctcc ttaggaagaa ttttatccat 55021 tttccttaga gtgctcatca tggcagttcc attgcacaat tccgggaggc atcatataat 55081 tcaacatgaa tagcaccccc tggagttgta caatattagg cacgactaac atttttattt 55141 cctgaaacac ttcccacact gagttgtact actaactctt ttcttaatac ttctgcttaa 55201 ttatactgca ttttatccag attctaatta ttgtttaaat cagtaagcaa gaccatgact 55261 tatcaatgag aaagaaatgt attttcaaaa acatttttga agtacattca taaacttcct 55321 cacctttccg taagcatttc cgaagccaga ggagaaatgg tgctaatgtc aggagggaga 55381 gtccagcagc agaaagtcca gctaccaagg gaatgttgga ctcagtggga gctaaggaag 55441 taagagacga agaaaggtca tgaggaagaa ttgatgttaa agtctctccg tcctgtccct 55501 ttggcctttt ttctgtacat tcattactag gagcagaaga gctatctagt ttaatacaag 55561 aagcagagat gtggcattac aggcctttga gatctgctcc aagccacctt tgaagctatt 55621 tccaccattg gcaggcagaa ctctaacttg ccaagctcgt tcacaatacc acaccacacc 55681 ttggttaata aacactgcac ttgcttgctc tcttgctctc actccctctt gttttccatt 55741 tcccctttct cctctcctct ctctgtctcc tttttccagt tgtcagaatt ctaccctttc 55801 catcaacatg caacttctgt tttttctcta tccccataca acttaatatt cacaacttgt 55861 caacctgggc gaactttctg gtttggatat aatgaatagt tgattactgt aacaagatag 55921 ctcccccttt ttctttttaa tcaccagaca accaccatca atcaatgcat caccttcaca 55981 ggtaggtagc aggccagacc agtgtcctgt ggctccacat gtccgagctg cagagccatt 56041 gagcgtccat ccttcaggac aggcgaactt gcacacagtg ccaaacacgg gctccccact 56101 gcagctcatg ttgatctttc ccggaactgc caggcttgaa cattttacca ctgcaaatgt 56161 taggtacaca ggcagagttt cagaaaaatc tactggaaaa cttccaaaac ttgcttaaaa 56221 gtcaacaatg aatgtaaagt gtaagcgcta cttagttttc agcatgtagg aaattaggac 56281 caaacccctt tggggcaatc taggttcaga aactttatga agtatttgac ctgtacccta 56341 aaaaagtctg cactcaattc taccttggca ggaaggaacc tcttctgtcc attgtccctg 56401 agatgtgcac tcaagttgag ttgatccatg taattcaaat ccctcctcac agctgaaggc 56461 acaagaggac ttgtaggtga attctccaat aggggaatga gcacacctca ccaaaccctt 56521 cgggggctgg tggacagcat cgcatctcac agctggaaca cacgagagag cactttagaa 56581 gtttgtttgc atctccagca atacgtttcc caaggtaacc aagttcccaa gctcttcaat 56641 agttcttttt atcttaaaat aaaataaaaa caaagactgt accttcacat gtgggcttct 56701 cgttgtccca ctcccctgtg gggccacatt ggagcctttt ggatcccttc aacacaaaac 56761 cctgctcaca ggagaactca cagctggacc cataacggaa actgccagaa gcactaggaa 56821 gacaattcat gtagcctcgc tcggggttgg acaaggctgt gcactggaaa gctgagacat 56881 caaaatgatg gtcagaaaat attgcagtgg aactagagag tacttggcgt ttgttgagtg 56941 aacccagttc attcaagcaa cacttggaga actgaagatt ctttataatt ccctggacaa 57001 atgggaagat ggctgtgttt tctttgaatt tcagccccct cactgatcat ggcactaatt 57061 aaaagactaa ttaatcagaa cattagttcc tgagcactgt tcttctaaca cacaaaataa 57121 attatggtcc aaggaaagat ttcacgcagt ctgaggacaa catatgggtc atggatgttt 57181 atagatggtg ccaaaaagaa agaaaagaaa gcacccctat aaaatttgtc tgttttgcag 57241 tttggttttt gtgttatgtt ttgctactgg aaatcattct gtgctggctt tggctaggac 57301 aaggccagtg cctgatagta aaaactgctt gttttcaata tccttgctct cactttaaag 57361 tgaattaaaa tttactgctt atatatgcat caatactatc tctgtagctg acaccatgct 57421 tgaaacagtc tcatcactgc taattatgag ccatttcaga agacaggtgt gatgagagtt 57481 ttacattcaa atcatgttct cattattctg ctttccgaat tttctaatat gattccttta 57541 gattaagaat tctgtctatt ccatgctaat gtctacaaag ttttatcagc acatcacagt 57601 taaaaaaaaa cagcaaaqaa ttcattctta acacatatga tcctttccct ggccaaacat 57661 tagttctttt aaatgaatct caaagatacg agggttgctc atcaaatctg atttctatag 57721 ttaaagtggg tattggtttt ttttttcact gtccaagttt gaagatggtt gttctttaag 57781 aaagtataaa tcgaaggatc tcaagcttac cttcacaaac tgggatttgc tgtgtccact 57841 gcccttgagt ggtgcattca acctgggctg gtccctgcaa catgaagcct tcctcacagg 57901 tgaagttgca ggatgatttg aaggtgaact ctccagcagg ggaatggctg cacctcacag 57961 agccattctg aggctggcgg acggccctgc atgtcacagc tgtaacaaat atacgcattg 58021 atattagcac ggcctagaat tagcttgccc atttccagta tgggttgaga gaaagaatgt 58081 tcacagtaag tctccatgtg gaacaactct acctttacac gttggcttct cgttgtccca 58141 attcccagat gaggtacact gaaggctctg ggctcccatt agttcaaatc cttcttcaca 58201 gtcaaatgta caggttgtgt tccatgggaa gcttccaggg ttttggaaac attccacgaa 58261 cccattggct ggatttgtca cagcatcaca ctcaaccact gaggatttta aagagcacca 58321 tgaattttac agaagaatga tcttttcact tcctattgag ctgggtgcct aacagagtga 58381 ggaagctgcc ttcaaagggt agatcccaaa gtcctatgtc aattcttagg gacatgcaca 58441 gccagaataa aagcttttat tctttttcat ggatattcta tcttttctga tttccacttt 58501 gcctatgctg agtggtctct aatctatgtt atcatttacg tgaggtaaaa atttaaaaaa 58561 aatagattcc agattaggag ttatgactag tactgacata cgtaggctat tcatttattt 58621 tagcccatca gagcctgaag aactgatttt tctttttttg gcctctggtt cagaaagata 58681 aaattaagag agaaaaagag atactaagac tgcttgacta tcatggtctt aagttagtcc 58741 catggcttgg aaaagttaaa cagggaaaca agatgagaaa tccattgaga tttctagagc 58801 tttattgttt tatggtctcc cttacaaatc accagagoct cagaaacacc catttcaagc 58861 atagaataaa aaaacctctc tcaacccaag caggtactgg gttggcaata tacattggct 58921 gagagaacaa attgtattaa aaacaaaaac aaaaaaaaaa ctttccctga agttttgaaa 58981 atgtaagttg aatcaaaaaa cagaagcaat gagggatgag ttacagaacg ttctgtgcat 59041 tctcagaggg atttaccatt gcaggctgga ataggagcac tccattctcc agaggacata 59101 cactgcatgg tctccatgct gcttggcagg taacccctat cacagctgat agagcaggaa 59161 gaattgtagc tgaagtttcc cagtgggtga ctgcaaacca ggcttccatg ctcaggggat 59221 tccagggctg tacagttcac aactgaaaaa gaaacccaaa tcagttctgc tcatctctca 59281 cctttaacag ataagaacac tggaaactag aactacagtt tggttttttt tttttttagt 59341 ttaaaaattt ataaaatttc taatggaatt tgtaaaattg actgtaattc tacccctttt 59401 cttttattca agaaaatgct gatccataac aacaacaaca aaaaagcagt gatgacaacc WO 00/09525 PCT/US99/17712 EPI-109 930 59461 ataaaaaaga aatattgagt gatatgggga gagtagtgta attgtgttta cctcaaaact 59521 gttcaaatta tatgaacaaa cacagcaaac ttaggtacca caacaaattt cttgttactt 59581 ttctcacaac tgctaaaaat actacagtaa gcttccaacc aggatgagaa ccattcacaa 59641 agctatattt caaatttaag tactagaata cattacaaat tttaaaaccc taatgctgca 59701 ctgtctacta tagtagccac tatctgtgtg gctactcaaa tttaaacttg aattcgttga 59761 aatcaaataa catttaaaat tcagttcctc agtgtcacca gccacatttc aagtactcaa 59821 taaccacatg tggctcatag gtacacactg gaaaacacag ctatggaaca tttccattat 59881 cacaaaagct ctactgcaca acgctgtgct aaggaatctt ggagagaagc tcatctaact 59941 ctcttaatgt acaaatttag gaactgagac ctcatttcat tcaagtgact tgctccatgc 60001 tacacggcta gtcattacag agccagaggc cagagcatga accaagatac cctggactct 60061 gtaactcact catttctact gcaacgtctt gttaccacct agatgaggtg agtacatgtt 60121 cctcgcaggg acacagaatt acagtttatt gaatgtgtcc tgtgtgccag gcaccatgta 60181 accatgagcc tatgaagttc acactattat tatcctcatt ttacaatgag aaaactgaca 60241 tagagagtta aactatcttg tcaaggtgcc aaaataaata actggtgaat ctaggactca 60301 aacccagcag ggtctgactt catagtctca gctcacgatc accatatgac accatctgca 60361 ccagggaagg gaaggcatgc agacctgact ctaatgccag ctaggacgtg agatggtgct 60421 accatctcaa gtgaagaaag aggcaagaac cagacttact ttgctcacac ttgagtccac 60481 tgaagccagg gtcacacttg caagtgtaat tattgatggt ctctacacat tcaccgtggc 60541 cactgcagga tgtattggta caggcagcta cggaaaatac aaagcatgat gaggaggact 60601 attactgtgc ttatactgag tgcctttgat tttagaatca acagtgtgca acagagacat 60661 cagcagtcct acagagtgcc atagacttta actgaagtgt tttacaaagt tccaaatctg 60721 agtttcaggc ccacctatcc taaaccttga tgctaatgta tagctgtggc tggcacctac 60781 cgtagaaaat ttacttcttc acaaactctg aagacagttc ccctaccaca aataaacaag 60841 taattaaaat atgtattgtg tgtgtgcatt tttatatgta aagaactaca tatttgccta 60901 cagtatttat atatatttta tatatataca tacacacata tatgtgtgta tatgtgtgta 60961 tgtatatata taaaatgtat ataaatgctg taggctatat atatatacac acacacatat 61021 atgtgtgtgt gtatatatgt gtgtgtgtgt atatatatac atatccacat attcttgccc 61081 acattcacac aaaacagcaa aagagagaaa ctttagcagt taaacagaat cttttggaac 61141 ataaaatgac cacaatagag agcagttttt gcatgctgta aatttgccaa gatgcccaca 61201 cactgaaact acctcccact gctgccgcaa actccctacc tgtgtagcat agggcaagct 61261 tcttcttgct gcacctctca tcattccaca tgcccacatc tttttctctc ttgatgtaga 61321 tctccacgca gtcctcatct ttttgcctat tgttgggttc acctggagcc cagttcttgg 61381 cttcttctgt cagaggtttc tgggttccta cccagaccca cacattgttg acttttctga 61441 ttccaatcca gtaataactt ggtgaatagc tcaatatgga gtttaggtac tcaatctctt 61501 ctttgttttg aattgcaacc aggtgtgtgt acctttgctg acaataagca ctggcctcat 61561 cataagtcat agcttccgtg gaggtgttgt aagaccaggc tccactctct ttaatgagaa 61621 gcactagtgg gagaaaaaga aaagaaatgg tagagtttgg tactgttgtg gtttaactct 61681 gacaactgtg ctttttattg tcttattttt ggcaatgttt gtgacatggc ccagactttt 61741 ctcatctttt caaaagtaag aagtacgtat gaagaaacag cgacttattg tttatctctt 61801 ttgtgactgc cacccactag gtaccttatc cacactcact cacaacatta tagtataccc 61861 attttgtagt agaataataa tcagaataac taagctttat tgagcactta gtatgcacca 61921 agaagcactg tatgaggtac tttccatgaa ccatgctatt gaatcctcac aatgcatctg 61981 ggaaataggt cattatgatc cacactttac acttaaggaa agggagacac caagaggtaa 62041 agtaaatgac cccaagccca gggaagaaca cattgcaggt agaggtcaag gatgctgcca 62101 gatatcctgt gcaggacagc cccagacaag caaggatatt tcagtctgaa atatctatag 62161 tgcgagaatg agaaatcttg gtctaatggc actgacttac ccaaagtgag agctgagaga 62221 aactgtgaag caatcatgac ttcaagagtt cttttcaccc aaaggtttag gcttgaaata 62281 ctttcctggg gagataaaac acaaaatgaa ttaaagaagg aaatcgtggg tagctagtta 62341 cattattcta ccatgatgtt taaggcagca tcctaagatt ttgggcaaag gacactagtg 62401 caataatctt tatttcagag tttaatcaaa taaataaaca aattttaaga ctttcattat 62461 ttaggtcaaa gagaaaagac aggttttagc tacaatacaa taagagcttg tacagatgtg 62521 gtttttatta gaaggccttt tgcatatctg tgtttcatgg cccgaggctg cccttataaa 62581 gcgttctgca cttaccgttt tgggaagcag ttgttcaaac acaggatctc tcaggtgggt 62641 atcactgctg cctctgtctc aggtcagtat aggagttttg atgtgaagtc agccaagaac 62701 agctgaacac tacttcggct gaggcccttt tataggaggg attgcttcct gtgaataata 62761 ggaggatatt gtccacatcc agtaaagagg aaatccccaa tggcatccaa aaactttccc 62821 gggaatatcc acgatgctta aaattacaat gatgtcagaa actctgtctc ttgaagctac 62881 ttcacctttg tccatgcctt tatatcgtat atgcaatttt attaatatga caaaaatgca 62941 tgatttttaa ttataataac ataaagtcta tgtctttaaa aagttgtaaa actttgcttg 63001 ttagtagtgt ctctcatgta gttgtggtag taattagaat ttcagaaaca gaaggaaacc 63061 aagaataggt ttgtcatcca tagtctacta ccttcaattt ctcattcata gctgtggata 63121 accaatcact actcattttt tcttcctttt tcacctgcca attcaacata tttaacatgc 63181 actgtctcac agaggaatga ctcacaaggt agatattaat cttcagattt tgcacggcag 63241 ttatgcctaa attaaaatat tatctaaaaa taatatctaa cactcaaatg gttaaaataa 63301 tgccttattt taaaaaaaga aaaatgggaa atagatattt acatctggga aagtttcatg 63361 gtttgttcag tgaaaaaaat aaaaaggagg ccaggcacag tggctcacgc ctgtaatccc 63421 accactttgg gaggccgagg caggcggatc acctgaggcc gggagttcaa gaccagcctg 63481 accaacatgg agaaacgcca tctctactaa aaatacaaaa ttagctgggc atggtggcgc 63541 atgcctgtaa tcccagctac tcgggaggct gaggcaggag aatcgcttga acccgggaag 63601 tggaggttgc agtgagccaa gatcacgcca gtgcactcca gcctgggaaa cgagtgaaac 63661 tctgtcttaa aaaaaaaaaa aaaaaaagaa aagaaaagaa aaaaaataaa acggaaaact 63721 atatatatat atttaattgg tcaaaatttt gtttaaaatt tttgaaatgt taatgtgcaa 63781 agaataaaaa ttcttccaca atgttaacag tgactaactc tggatggcag gatttgggat 63841 aatttttata tccttcatta ttattttcag gattttaaag tttttttcaa tttccctttt 63901 tttcaccttt atagtaacaa gaatacagtt taaagaaact tgtctctagg ccaggcatga WO 00/09525 PCT/US99/17712 EPI-109 931 63961 tggctcatgc ctgtaatccc agcactttgg gaggctgagg tgggtggatc acctgaggtc 64021 aggagttcca gaccagcgtg gccaatatgg tgaaaccctg tctctactaa aaatacaaaa 64081 attagccggg gtgtagtggc gcatgcctgt aatcccagct actggggagc ctgatgcaag 64141 agaatcgctt gaacccagga ggcagaggtt gcagtgagct gaaatcacac cattgcactc 64201 cagcctgggc gacagagcaa gactccatct caaaaaaaaa gaaaaaaaga aaaagaaaag 64261 aaaagaaatt tgtttccaaa tgcaacagaa ggagatgtat gtggtatcct atattcctgc 64321 tcttcatttt gacatttctt ctgggtgatt gtatacattc cccatctctg catcttaccc 64381 tatctaaatg atggtaacag taaatgggga tcattttaat ttccatattc tgtaggtttt 64441 cagagctcaa gtcaagctaa tattctatat ctacagcctt tcaaaatagg aggtctatct 64501 aaaaatgtac tgtcagcaga cctgaacgag tagtggtaaa agcctcgttt ttctctttac 64561 ttgttagcac tggtctttct gtgttcataa agatgtcaaq acccaaaaaa aaaacaagaa 64621 aagagaagaa aaattccaaa aaagacaact gattagaaaa aaataactta attaacgaat 64681 ttaattcaac ccctatcaaa aagcatagaa tttattccct ccaccttacc actctcttac 64741 atgatccaga tactgacatt attccaattc tttatcccac tttacttagc tcaatgtggt 64801 tgttgcttca ataaattcag aagagtaatc actcatatag tgtttattta gattttaggg 64861 cagaatgtca agttgggtta atacattatc tgtatgtatt ttatttttaa taaagtatga 64921 atacataatc tgctattttt aaaaagcatg gtcaaatgta tagagtagcc aaatcttaaa 64981 aaacaattta tcttcgatat caataaagta cctaataatt atattgctaa tagaaattag 65041 tcgttaacat ccctagataa ctaactttat tattgcgaat ttttcataac taagtttata 65101 gtttatctct tccccttttt aaaattagtt caaagatatc taaaaatagc cccagtggtg 65161 atgaagtttc tattttactt acatatatat gtcctggacc cccaattata atctctaaca 65221 tttattgagt gcttactatg tgccaggcca tattctgagc attttgtatg ttcacctatt 65281 gattattcaa tccgtacaac agcctatgaa ataggtactc ctattatccc cattttacag 65341 atgaggaaat tgagaatctg gggattttat ctcattcaaa agcacagagc taagggttga 65401 aaccaggcag ttgatatcca gagcccactc ccttacctgc tactccaaac catgatttct 65461 tttgttgtta tgccccgaga ttccttgttc tacccaagtt tcctgtactc ttcttgccct 65521 cttcttcctg agacatcctt gaccatcaca gctctccact gagataactg tgtcctgggt 65581 tctgagacat gggggctgga agggacccca gggacagtga gcagtaggga gaggatgcag 65641 tgagaacaga ccctggatcc ccggtgcata ggcagggaga aagtggacaa aggaaaaaac 65701 aagcaaggca ggtggagcca tgcctaggta aagttgatcc ctaagccaca gttcccagaa 65761 gttcctgatt caaaagcaaa ttttctctaa ggtcaaaggg caaactgatt attctaaatt 65821 ctaaactgat tatttctaaa ttgagaaagc ttcagggaga gatcccaata ttcgaaggat 65881 aagagaaatg aggagtggaa gagataggtg agtaacagta acttaaatgt agactatata 65941 taatatataa tatatgtaga gtatatatat ataattacaa tatattatat atgtggaata 66001 tatatattat ttatatatat ttatatattt tatatatata gatattttta tattttatat 66061 ataaatatag atatttttat attttatata taaatataga tatttttata tatattatat 66121 ataaatatat gtaaaatact gtgaaagaaq aatagaatct tgagacctca aattcactat 66181 gccaaaggga aagttaagct tgggaaatga gtcatgcaaa aactgccttc cttttgttcc 66241 caaatacctg taatttcaca tgcttacttt atcttatata aaatgtagat gtactgagca 66301 tgagatccat gcataatttc cctctagtcc cttcttttta catgtaaagt gtagactcac 66361 tgagtgttac agagccttgc cacaatgtaa acacttgtct cattgccaac ccatctttcg 66421 tttattttct tcccctcctg cttgctcttt cccctctaaa gatggaagtt cccaaaactc 66481 tctttggaaa aagcgcaggt cacagatcct acagtgattt gtgtttcttt tacctgggac 66541 aaaataaacc tctaatctgt tgagatatgc ttcagttact ttttggttta caatatgtac 66601 atgtatgtat ataatttata tgtatataat atatgtactt gttttaacca gaggtatgtt 66661 attcaaaatc cattcatcct tacaattacc tgcattctcc cacagtattt tctgtgtccc 66721 tgcccccgag gttgtcactg caaatcaggt acatggatac tgggagctga tgggctcccc 66781 tctggctacc tgggctgctg aaggggccat agacagaccc agctttcctc tcgtggagag 66841 gccctgggcc agcgctgcgt gggagtggga ttacaaccag actatagctt cttcacctgc 66901 tttttcctat caggatttca taagaggcaa ttgcttgttt tttgagggtg ggggcaaatc 66961 agggggagtt gaagaggaaa ttgggtaaga tttgaatagt tgggcatgtt gaatattatg 67021 aatatcatct ccctcttcaa ataatccaaa atataccccc aagaaacagg ctgattagag 67081 gtgcttcaag gctccactga atctcccaag ctctgaagat gtagctagct gttaccggat 67141 tgccggtttt caagcctcgc ctcacatgga ccctcttggc agtttctcgc atgggggaag 67201 catccgctac atagatggga atgaaaagag gaaagaagac ggtgcaaact caggcacacc 67261 ccggtgtctg ccaccagtgc tatttaatct ctgaggtgtc acccttcctg gctttattgt 67321 ctcttcctgg aagtctcttg tcctctcctc cacacccttt aatcaggcat caaagacttt 67381 aaccagtttt gctgtgtgcc caggcccact cattctcact tttatggcaa agggagtggg 67441 agacagagag atagccagaa agaagagatt ggggacccca agacaaatgt tagaatttta 67501 accaaggcca ccctgtggac aggagattat tgggtttagt ggaaagcagc actggccaca 67561 accacacgtg gcaaaagcat ctatcgagga gtgaagttat atttggtgaa tgtgaccggg 67621 aagcaggggc agtggtgtcc tcctgccttc ctgaggcact ctgttccctt acctctgcga 67681 aggcttattt tacccctgag tgcttagttt tgaaagcctt agttccctct ctcccataaa 67741 aaagctctac tctgctaaca tctaagttac ctttgcagag tcttaggtag agggaggaaa 67801 tcccaataaa gattccaccc tatctgcaaa atacaaacat ggtatttctt gcattcccaa 67861 aattgtgaaa gaaaatgtgt atcaccacag tagagaatgg cattttttgt ttgatcaaaa 67921 cctaaatata tttgatgaaa atgtgtctgg ttctaagttt atttcccaga aagccatgtt 67981 tactcacttg gaatttatag acatcttata atatctgagt cgagtaggag ctccgggctc 68041 tacctcactc ttttctccca cacccagggg gaagtgtagg gttctcagac tttagaataa 68101 agaggaatca cctggacaac tcacctaaaa tgcacatctt caggtctcat actcagaggc 68161 tctgactcaa caggtctggg tggcgcccaa gaatttgggc tttaaatgag tatctcagat 68221 gattctaata cagaatgtgt aagatgacca gatcctatca cacttagatg tattggccta 68281 gggccaccta acttggagaa aatgttagta agaccccgtg gttggtgctc agctataggt 68341 accagaattt tgatcaaaat ttactatcat tgtgacactt ctcttcggaa ctggaaggcc 68401 agaaccccac ttgtaaagtg ctgggaaaat acaaggaaaa tttagggtga gtagcatttt WO 00/09525 PCT/US99/17712 EPI-109 932 68461 gaattcttac acatggaaag taaatgtata agaattCtta ccaataaaaa aaaagcaaga 68521 gagaatagct gctaaagaat taacacaaat atgtatatat tagttattct cttttctcct 68581 ctgattccag aggactttgt aattccacta attcttcttg agcttccagg atgatctgag 68641 acttgaattt ttcatgtgct ttttgcttcc tatttggcag catcttatct tgaagtttcc 68701 gctttctgct tggggaccta aaaactaact aatgggaatt tcttcaaaat gagcaaactc 68761 tggtgaattc ccaaagcgga agaaacaagt gaggatcggg ctggttaatt aagagaactt 68821 ttcctgaatg tagccagact gtttgccgac tgttgttaac atgagggaag aaatacccct 68881 ggattttaga agagcccctt gtttgttttc cttggccatt tgtgctgctt gttttgtaag 68941 tcagaaattt cctgaaggac tattattagc tttgttctca cgtcagaaaa cttctgctct 69001 ggccactttt aaacatataa cttggatttt actgtattag aaaatgtaac aattacagac 69061 agcactaaaa ggacaccaaa gggcaaagaa aatgggtaac ttttttttct tccccaaatc 69121 taaaataggt gattttggag aagtaggaga aaaacctgga ttttctagat ctctttagag 69181 ctcaacaact gatatagtta attatgtaag tctttgatat ttggaaatga ttggattaac 69241 cggataacaa tgaatattta aatacagtga tttggccagg agcagtggct catgcctgta 69301 atcccagcat ttggggaggc tgaggcgggt ggatcaccta aggccggqag ttccagacca 69361 gcctggccaa catggtgaaa ccccatctct actaaaaata caaaattagc caggcgtggt 69421 ggtgcaagac tgtaatccca gcaactcggg aggctgaggc aggagaattg cttgaacccg 69481 ggaggcagag gttgcagtga gccaagatca cgccattgca ctccagcctg ggcaacaaga 69541 gcgaaattcc atctcaataa ataaataaat aaatacagtg atttaacaca agagatttct 69601 atttcacact aatgagctct gtcactgggg caagcttctt tgcctcatta agtctcagat 69661 ttcccgagag cttatttatt tataccaaga gtgctttact accgtctctg ctagctgtga 69721 cataatatga caaaaggtat aaatatggga aaaggcacta atttatatca aagcgttctt 69781 cgtttttcct tgctgtgaag tttttagcta ataattcata agaatatacc atatttagag 69841 tgtttactat gcatgggcct ggcacttcac atacattgct tcttacaaat tttacaaagt 69901 gaaaggtaga tattaatctc attttatgga ggacaagata gagatctgga gaggttacat 69961 aacttgccag tgttttttca gttaataaat ggtagggtgg agattcaatc tgtgttactc 70021 taaagtccgt gtccttttta ttggctccat gcctactcag atttaaatct cagcagggaa 70081 gtaaacctta gtttttacat gagaaaatgt tacagcagcc ttctcggctt cctttacccc 70141 catcccagtt tcacgagctt agtgccttag atcgggttcc tttagaagca gacctcgaaa 70201 taaggatgtg ggtgccagtc atttattgaa aagatgatcc caagaaagcc tagtaggaga 70261 gtgaggaagt gagatgggga aaggaagaaa ctccacaaga agtgtgttaa taagcaggtt 70321 accgctgtgg gcagccatgg ggctcagctg cactaacaaa ctctgtctag tacagaaaac 70381 ctcagggtct ccccaaggag gggcaagaag tctgcctagg gtatatatcc gccaactcag 70441 tcactggctg agagctgatc ctgggagggc atggttaatt cctctgcact ttcaagtgga 70501 ttcctgtggt cagaaaaagc cctctacaat gaattccaga tgcttgtatt taaatctgac 70561 atgatctgaa tgctgtgttg ggacagggtg ggcgttatta gttttctgtc attactgtaa 70621 cagattacta caaacctgat ggctgcaaac aacacatatt tattatgtca tagtttgtgt 70681 gggtcagaag tacaggttag ctcaactagt ttctctgctc taggtttcac attgccaata 70741 tcaaggtgtc atccagttgg gctcttcttg ggaggcttgg ggatgaatcc actttcaagc 70801 tcattcagat tgttggcaga atccagttcc ttgtggttgc aggaccaagg tccctgttgc 70861 cttgctggct gttggccagg agtcattctt agcttctaga gactacctgt actctctgac 70921 tcgtgtctcc acttcacctt tcaaaccagc agcggctagt cgagtccctc tcttcaaatg 70981 tctccaactg tgccttcacc tcatttctcc tctgtgtacc atgtctgcct ctactgcttg 71041 taagggctca tgggattaca ttggatttat tcaatccagg ataatctcca tattttaagg 71101 ctagctgact agtgatctta attccatcta caaagtccct tccaatagta ctgtattagt 71161 ccattttcat gctactgata aagacatacc caagactggg caattcacaa aagaaagagg 71221 tttaattaga tttacagttc cacatggctg gggaagcctc acaatcatgg cagaagtcaa 71281 ggaagagcaa gtcatgtctt acatagatgg cagcaggcaa agagagagag cttgtgcagg 71341 gaactcctct ttttaaaacc atcagatctc ataatactta ttcactatca caagaacagc 71401 atgggaaagt cttgccccca tgattcaatt actcccacca ggtccctccc acaacatgca 71461 ggaattcaag atgagatttg tgtggggaca cagccaaacc atatcaagta cctagattca 71521 tgtttgatta aacaaccagg gagcagaaat cttcaggagt ggggggcatc tttagaattc 71581 tgcccaccaa ggctgggcgc ggtggctcac acctgtaatc ccagcacttt gggaggccaa 71641 ggtgggtgga tcatgaggtc aagagatcga gaccaccctg gccatggtga aaccccattt 71701 ctactaaaaa tacaaaaatt agccaggtat ggtggtgggc acctgtagtc ccagctactc 71761 aggaggctga ggtaggagaa tcacttgaac ccaggaagcg gaggttgcag tgagccaaga 71821 ttgcgccgct gcactccagc ctgggagaca gagcaagact gtctcaaaaa aaaagaattc 71881 tgcccatcat agtaggctgt cctacagaga cataacccag gaattaggtg aatggctaac 71941 ctaaattagc actgtgatgt gttttctgac ttggtcctta tagctcctct gcttagatgt 72001 ggaactaatc catgaatgca agggtttgtc tagagtttta agtgggagtt aaatatccaa 72061 agtacaggag atattatggg tgcctcatcc atgtcccctt ggcatttatc tttcttggat 72121 aacccaactc tattagtttt tatatctcac ttgttcctat actctgtgaa ctgatgtccc 72181 ataaatagac atttcatttt gccagtcttc ttgaacaata attacgatta ttaatctagc 72241 agttatcatt aattggccac ttcacattag acacagcact taggacttaa gaataccatg 72301 tcatttgatc atcataatat ggtcaggaat taagtattgc tatccaaatt ttacaaagaa 72361. ggcactgagg gttagagttt aaataacttg cttaagatgt catagcctgt aagtgacaaa 72421 actaggactc aaatacaggt ccatctgact ccaaagtcta tgttcttggc taccacactg 72481 cctctcctac aagtgacctg tggttttact actatattca cactctacta actttaccat 72541 ctcccatgag tctgtctaga ggagggcaca cacagcacag aaaacacatg aatgcaaaat 72601 aaggaagggc ctacttacta cacagagcca ttctaatacc tgatgtttgc tctaatccag 72661 ttttactatt aattagttgc tggtgcccaa gtttttactg agaaatgggg ataattttgg 72721 aagtcataat gatgccttct tctcataggg tattttattt gttgttgtat ctccaggccc 72781 caacacagcc tggcttttag taaatgatca aaaatacctg ttgaatgaat aaatggagtc 72841 acctgaaaca tgttaaacat ttgttcatgt gtcctaatcg tggatttcag gatagtaagc 72901 atcctaaaag gaaagcatgc acactgttct tgctacatta atttctcaca atataaaaaa WO 00/09525 PCT/US99/17712 EPI-109 933 72961 agaaaagcat ctgaaaaaag ctgccagccg ctgtgtctcc taatatcaaa ctgagcacag 73021 atatggagaa gctaagggag agggatgatg ggccatgcct ctaacctcat catggcaaaa 73081 gtcctggggg tcagacccga ggagagcagg aagtgtcttt tgagggatac atttccacag 73141 tggaaataat gagacttaaa taaatattat atacacagtt caactgtttt tatgtgtaaa 73201 ggtagtaggt tttcacagta aggaagcact tctttttttt tttgtttgag acagagtctc 73261 gctctgtctc ccagcctgga gtacagtggt gctatctcgg ctcactgcaa tctctgcctc 73321 ctggattcaa gtgattctcc tgcctcagcc tcccgagtag ctgggacaac aggtgtgtgc 73381 cattacacct ggctaatttt tgtattttta gcagagatgc ggtttcacca tgttggccag 73441 gctgatctcg aactcctgac ctcaggtgtt ctgcccgcct ctgcctccca atgtgctggg 73501 attacaggca tgagccactg cactcaccaa gcacttctac tgatagcatt tacaaaccct 73561 tcttagaata tttaaaaatt ctaagagaag agtaaattga gccttcccaa ctaatactag 73621 gaggttataa ccttcatacc aaaactggac aatgcttgca caaaagaagg aagccaatga 73681 ggccacctag aaggaagact gggcattggg cccagtgagt cctggaaacc tcatctgtgc 73741 cagccacccc ggcatggcct gtatgagtgg atgagggtga cttgtccaca gacaatagcc 73801 atctagctgt gataaaggag tcaaggtagt cagctgcatc tctttcacct gtttgccaat 73861 gttacacagg ttgaaaagct aaggtttatg taaagcaagc atcaaagatg atgaaatgat 73921 caacctgaca atgagtacta tgctgcattg tccagaaagg aactgtggaa gattttgggc 73981 tgaatttcaa aacagaattt cctcactctc tggatgttgg cttacttggc ctttgatgtt 74041 cagaggtggt gcctttgtgt tgttgaacaa tgttgatttt ggagagaaaa cagaqttgaa 74101 aaacccacaa gtcattccct ggggagtatt accggaatac agaggataat ttcagcaagc 74161 cagcaaggcc tcatctctgc ttctaataga taggaagaaa ggaagagagg aacaatactt 74221 ttttaagaag ctcagcttta tcgccttatc tcatagaaag atgcctccag tctgtctggc 74281 taaaggtaat tggcatggga aagtctttat ctgtgattct aacaagtgga atgtttccct 74341 tcattaagag agccttgtct ggcttgggga aatgaaacac tttctccgat atgagtgggc 74401 tgtaacccct gctactaaat actcagaaga aataaggcgg ttgtggagca gtcaggaatg 74461 agtcacttgc ctccctggaa tattcagaaa actgaatcaa aagtacattc ttctgggttt 74521 tcttagtcta atagactaag ggtctctact ttgttaaatt tctgggaaac agcatagaat 74581 gggagaaaaa actggtcact gtagtcatgc aaatctgcaa aacaaacaaa aaagtctggg 74641 tattgctgct aactagctat gtgaccttaa gcaaggtatt aactctctct gaatttcagg 74701 ttcttcatct gttaaatagc atatctgtaa aatgggaatt attttcatat cataatgctg 74761 tagctttaaa aaataaaata aaatggatga gataatcaga attaaagagc ctgggatata 74821 tagttaatat atagcagcat gtaaagatcc tgttagaaat gctaatttta cagttaacca 74881 tttggagatg atccgccaaa gctgctagtg tagaggcaac tgagaatttg cctgtccttc 74941 agaatatgaa taaataactg tcaatgatgt ctcaagccta gaaaaaccta tccatctgga 75001 tgggtgggaa atttctaggc tagtattgag aagcccattt cttgggaaat aggtcctgga 75061 ctgagtgaag gaaaagaaac agtaaaaccc atggtaaagc agcaaggctc tctagaggct 75121 ctggagagga tgaattgaat tctagaagat gaagtaggga agacgcttta ccttcttgtg 75181 aaatggattc aaagattcaa agaccttcgg gaatctccaa ttgtataaat ggcaccatag 75241 ctgtatgttc catggaacac tacttcccag agatgcccag tgaaaaaaga atgccacagt 75301 caaataagtt tggaaacact ccattatgtg gccacctcct tgaagactct aatgcacatt 75361 agcatgttaa acagtcttga gaagtcctgc agagcagaaa ttgcttcaca tctgctaagc 75421 cggcagtttc ccaatatact tgattatgga tagttttttc cttacaacac cattctctga 75481 tatgcttcca atgacatgaa ataaatatat atgcatgagg ttcttcatta gggcatactt 75541 tttaatagaa aatattgaga ataatctaaa tataaatgca cagcatttac cttttctgca 75601 taaactatat acaggcatac cttggagata ctatgggttt ggttcccaca atatctccaa 75661 aaccacattc ggttttatga ccactgccat aaaaccagcc acatgaattt tttggtttcc 75721 caatgtatat caaagttaca tttttactat accatagtct attatatata caatagcatt 75781 atatctaaaa aacaacgtaa acaccttaat ttaaggctgt ggctggtttg attttctacc 75841 cagaccacta aaactttctt catatcagca ataaggctgt ttcactttct tactattttt 75901 tgtgatagca cttttccttt ccttcaagaa tttttccttt ctattcacaa tttgtttgat 75961 acaagaggac tagattttag cttatctcag tttaaggtgt ttacattgtt agctaaaaat 76021 gctaatgatc atctgagact tcagcaagtc ataatctttt gctggtggaa ggtcttgcct 76081 cagtgttgat gtctgctgac tgggtggctt tggcaatttc ttaaagtaag acaacaatca 76141 agtttgacat atcaattgac ccttcctgtc ataaatgatt ttttttttct ctgtagcctg 76201 caatgctctt tgatagcatt ttacccacag tagaattttc aaaattggag tcaatccttt 76261 caaactctgg tgctgtttta tcaactaagt ttatggagta ttagaaatcc cttgttgtca 76321 tttcaacaat gttcacacca tcttccccag gagtatattc tacctcaaga aaccactttc 76381 tttgctcatc tataagaagc agctcctcat ccactaaagt tttatcctga gattgcaaca 76441 attcagttac atcttcaggc tctacttcta attctagttc tcttgctgtt tctatctcat 76501 ttgtgcttac tttctccgct gaagtcttga accccttaaa gtcactcatg agggttggaa 76561 tcaacttctt acaaactcct gttgatgttg atattttgac ctgctcccat gattcatggg 76621 tattcttaat ggcatctaga atggtgaacg ttttcagaag gttttcagtt ggctttgccc 76681 ggatccatca gacgaatccc tatctatgga agctatagat ttataaaatg tatttctttt 76741 tttgtggggg catagcgtct caccctgtca cccaacctgg aatgcagtgg cacagtcata 76801 actcactgaa gactcaaact cctgggctca agtgattctt ccaccttggc ctcccaaaac 76861 actggattac aagcttgagc cactgtgtct agcccaaaat gtatatcata actaatgagg 76921 cttgaaagtc aaagtgactc cttgatccat gggctacaga atggacgctg ggttaccaga 76981 catgaaaaca atactcatct cctcatacat ctccttcaga gctcctgggt gagcaggccc 77041 attgtcaaat gagcagtagt atcttgaaag aaattttttt tctgagcagt agatctccac 77101 agtggactta aaatagtcag taaactatgc tgtaaacaga agtgctgtca tccaagctct 77161 gtttttccac tgatagggca aaagcagagt agatttggca taattctcta gggccttagg 77221 atttttggaa tggcaaattg agcattggct tcaacttttt tttttttttt tttttttgag 77281 acagagtctt ggtctgtcac ccaggctgga gtgcagtggt gcaatctcgg cccactgcaa 77341 gctctgcctc ccaggttcac accattctcc tgcctctgcc tcctgagtag ctgggactac 77401 aggcacccgc caccatgccc ggctaatttt ttgtatttta gtacagacgg ggtttcgcca WO 00/09525 PCTIUS99/17712 EPI-109 934 77461 tgttagccag gatggtctcg atctcctgac ctcgtgatcc acccgcctcq gcctcccaaa 77521 gtgctgggat tacaggcgtg agccacagcg cccagcctgt cttcaactta aagtcgccag 77581 ctgtgttagc ctctaataag agagtctgcc tgtcctttca agctttgaag ccaggcatca 77641 ttctcttctc tagctatgaa aatcttagat agcatcttct cccaatagga agccattttt 77701 tatgccctaa aaatctgtcg tttggtgtag ccaccttcat cattgatctt acctagatcc 77761 gctggataac ttaccacagt gtctacatca ttacttctgc ttcaccttgc acttttatgt 77821 tatggggatg gctcctttcc tctaacctca taaactaacc tccactagcc tcacattctt 77881 cttttacagc ttcctcgcct ctctcagagt tcacagaatt gaagaatgtt gggccttgga 77941 ttacactttg gtttaaggga atgctgtggc tggtttgatt ttctatccag aacactaaaa 78001 ctttcttcat atcagcaata agactgtttc actttcttac tattttttgt gatagcactt 78061 ttcctttcct tcaagaattt ttcctttcta ttcacaattt gaccgtttga tatgagaggc 78121 ctagatttta gccaatctca gtttacacca tgcctttttc actaagcttc atcattttag 78181 ctttttattt aaagtaagat gtgtgaccct tcctttcatt tgaacactta catgatgatg 78241 cctggcttca aagcttgaaa ggacaggcag actctcttat taggggctaa cacagctggc 78301 gacttttaag ttgaagccaa tgctcaattt gccattagaa gccattgtag ggttaattaa 78361 tttgcctaat tttaatatta tggtgtctca gggaataagg aggcctgagt agagggaggg 78421 agatggggaa acagccagtc atcagagcac acacaacatt tatcaattaa gtttatcacc 78481 ttgagggcac aggtcatgat acttcaaaac aattacaata ataaaataaa aaatcattga 78541 tcgcagatca ccataacaga tataatgata atgaaaaatt tgaagtattg tgagaattac 78601 caaaacgtga cacacagaca caaagtgagc acatgtcatt ggaaaagtgg tgctgataga 78661 cttacttcat gcagggttgc cacaaatact caatctgtaa aaaattcaat tatctacata 78721 gtaccataaa aacaaggtat acctgtttat ataatcaaga ccaacagaac cctagagaaa 78781 atagctcact ccctagctcg gagacattct aaccaacata cacttacctt tctttttgct 78841 gtgtacagaa ttcaaatccc tgtctcagca aaattgcaaa gtatcaaatg tcatgtccat 78901 ctaatactca aaactgcaaa tgttaagtct tgtaagccca gagaccactg tatatacaag 78961 tgttgctata agcattagtt cttctccaaa gaaaatagtc cacttggtag aaacaaacaa 79021 aaagaaaaaa aaagaaagaa aaaacatttt ttacaagaag attcagtctc ttacctacat 79081 aagcaaaaat atgagatgtt ctcttatcat ttttccatct atcttataat ctttggtgct 79141 gacttagaca ctcattttcc tttttgtacg tgaccatgta aaagttcaag tcaagaaaaa 79201 cttgttttga catttgtttt gctgagtgat gggtccctaa aagaaatttg gctttgcttt 79261 tgaaaagttc agcatgatat tgtgtqaatt tttcatggct aatgattttt agaacagttg 79321 tgatgtgttt aggtgtttta agaatatgaa gcattcagtg gtttaagttg gttgttataa 79381 aatgaaagaa tatgaaggaa agccttcttg tcttagaaca cactgattca caaataagca 79441 gcttctctca aaatgttgta attacaaaaa ttccaaggca aatataataa actccttgtc 79501 ggtgctatgt ctagaaactt aacagcccca aagaaagtcc tgacaaggca aaaaatatat 79561 atatatatac aaattgtgga agcagggtgt tgaaagaaga ataaagacta tataaggaca 79621 aactgtttaa aagggagggt atccttgaaa gcttgacact tgactctttt gacgaggctg 79681 agggaaaaca ctcagtttca tagattgctg gtacggatgt aaaatagtga catccctata 79741 gagaggaatt tggcaatatc tagcaaaagt gcttatgcat ttattctttg acctagtaat 79801 cccgcttcta ggattagtgg tgaagataca cctcaacaat aaaaatatat atacattagg 79861 ttattagtta tggtttaatt tttaatagca aaatatttaa aacaacctac atgaacaaat 79921 aggagactta ctgaataaac tatggtatat ctgtacaata aagtgcaatt cacttatgtt 79981 gttaatttgt tccaaaaatc cagagccaaa gagtatttgt tatgctctct ttagtataag 80041 aaaggggaaa taagatatgt gtgcatctgt ttatttttgt gaaaataagt acagaaagga 80101 taagtaagaa actagtaaaa ctagttatct cctagtgtta gtagaaatag aatgaaagtg 80161 aattaggctt ctttgagtat atgtttatat atagttttga cttttgaatt atgtttatgt 80221 ttacatagtc aaaaatataa attaatcaac agaaataaca aaaaaagaag aaatcacaag 80281 ctttaaaatt taatacaaac agaaataatt gaatctaaca gtatatcaaa gtgataacgt 80341 aaactcagaa gaaaaaaaca taatccaaca taccagtgga acacaatatt ctaactgtat 80401 acattcagtg gttatagtct aaggacaaga aaaattgcaa aaatatcttg aactttagct 80461 tgtaggattt ttattggtag caatactaat gtactaattc tgaaattaat gttcgtgtat 80521 tatagaattg agtaaatgaa taaatatgtt gatgttattg ggaactaaaa ttatcattct 80581 gggagtagag aaatataaat atggacttgg caaatgaaac aaagacctgc agagagataa 80641 ccatataaac tcattatttt aaaaattata agtgtcctag ctctgttact gaaaaggcct 80701 agattcaatc ttatcttgat agacaggagg gcaccccttt ctcagaacat ggtttccaaa 80761 tgccattctc cattaaaagg aacaaggtct tcttggagaa aagactgatt ctaggtctgg 80821 attaggtaaa gtacaacgtt agtctggaat ttcttgctga atcagaagta agaaagtgct 80881 caaaaacatg ggaacatgtc acaaacacac gtgaggcaac ttgaatcctc actggccata 80941 tttaggacaa tcgagcatca aaaaaaaaaa aaatgttgag aataatggat tctaacactt 81001 aaaacaaaaa ataatccata gcccacagaa ggggaagaga gggggagctc ttatttacag 81061 atgaatatca aatagcaaag acagaagaaa tgacagaatt agagaaacat cattttgcaa 81121 aacaccactg taataatcaa ttcaggcaag tattattaat ggatgtatta ctattgcgta 81181 aaaccagttg gggaacagga tattcataca gtctgaaggt gtcaccctaa acataactta 81241 ttacaagtgg aaaatggtgc ctttacaatg aagaaatcta gcagaaacca tcttaatcta 81301 gtgatcaaac ttagtatcac caataatgga tcatactgag tcatgtgtct cctaatatga 81361,tgcaccagga aggatgcaac gtcatgaacg ttgtattctt ttgtattcaa cagaccacco 81421 agggtaaagg cagctttctc acttactaat cagaattgtt ggttttaatt cattttggat 81481 tttaagattt cttactttct tgtcagctca gaaatttatt taagatgatt tttatctttt 81541 attcaatact ttagcttgga gaaccattca gagtttctaa ctcattgtat tgccaaaaat 81601 agaaaacagc atggtttctt ttgaaaatgt ctaactttaa agttacttgt gtgtgtcact 81661 cagattcaca tagctttttt gcctagtaat gtagtatcat gtggcaaggc tataaaaatg 81721 tttacaatct tttatttaat atgactcttg agagtttatt ctaaggaaat aattgaatag 81781 taacaaaaca ctattaacac aaagcatagc aatttgattt gggcaaccaa acactggaaa 81841 caacctaaat gtccattaca ggaatcattt atgaagcaaa cactaaaata tttattgtga 81901 agattatgag aacatagaag acagttatga gagtaaattt gaaaacctga acacaaaact WO 00/09525 PCTIUS99/17712 EPI-109 935 81961 tacatatact ccaattgtaa cttataaaaa atacgtgcat ataaggataa aacagtacaa 82021 acaaaaaaat agttgcgtta gattggtaga attatggctc cttttgctgt cttaattttt 82081 tccttttaca ttttgataca ttattttaat tttaatttta aaattcaaaa gaatttgcca 82141 ctcatctttg ccacttcaag gaaaaaagaa atgtgttcga ttattctgtt cttagtatag 82201 ttttggcaat ttcctcacgt gtaaaaagag aatactatta ataatttcag tatctataag 82261 acaatataaa attaaagaat ctagcccagt aactggtaca tggaacgtaa ttaataaatc 82321 attatggact ttttttctca cacccaagta gggaggaatc agtggtcccc tagaggccca 82381 gtgtagaggt ggcagcacca atccctaggg gagaagatct tggtgatgat aattcctgag 82441 cagacagtta gctgagaatt caagagcaga aaagtaagaa agaaacaact tcttgctaac 82501 acctttccac ccacgtttcc ctgttctgtt gtactctgct taccctttca tggatggagg 82561 cagaggaaag agaaccaagt ttgctcttag tcattcacta tgttgtttaa tctgccttcc 82621 atctttctta tcagttcaaa ttagaatgta gacctgaatt taaatccccg ttctgtcagt 82681 tataatgtga ccctagacaa aacacattct ctgaacctca gagaacattc ttcatttgta 82741 gaatgggaag attaatctat attccacttg gatggcaagt cttttataaa ctttataacc 82801 taaacatgtg tgagttgcta gtatcattat gttggtaaag ttattctgag atatgataac 82861 agaactgttt tgtctaactc cactagcatg gttcaggttt agagagtgtg gaattaaaag 82921 gctttatcct caaatatgac ttaaatccga tttttctcat ccactttcct ccacaaacaa 82981 atcctcagga aatgacaaac tttacatggt taaacatcag ttttgtttag tctttgacat 83041 ccacatggtt aaatcataca tttgaaaact gcttatattt gtgttgtcta tgtctaaatt 83101 gaaaagactt attgaggaat agaagactac acatttttca gcaaacactg cacgttttgc 83161 agaatttccc caggcaccag tctccaggaa tttattggct actaacaata ctaagatatg 83221 gatgaatgag gaaatcaaaa tggagatctt gcaagttttg tgagaatggg tgaatggtcc 83281 aaatgaagag ataagttgtg aaatattagt acaagtaaaa attatttaca atgaaagaca 83341 ttttgtcaat agctatgaga attttaccat tgacccagaa attccatttc tttcttcaga 83401 aatacccacg taggtataca tataaaaagt taticattac agtatcgttt ttcataggaa 83461 aaagttttaa aaatcagaag ctatctaaac tatggtatat ctaggtcata gaaatcaaat 83521 gactaaaaat gttaatataa gcatatgttt ttaaattaac ttggcttggg tcttcagcaa 83581 aattggcttc ttaacattgc actccagagt tagacttacc cactcagtca cttatcatgc 83641 aggagcagac tcctaatacc acatatcata gagcagagta ggacacaggt tctctgcagg 83701 caggcaaatc ccaaagagaa gggaggaaag ggctgagaca ctgcatggtc aatttcttct 83761 gaactctgca atgtacggag gtggacagtg tccacaaaga ttgctcccct ggacccacca 83821 tcataataac acaacggctt tgttttgttt ttgtttttgt tttttgacac ggagttttgc 83881 tcttgttgtc caggctggag tgcaatggtg tgatctcgac tcaccacaac ctccacttcc 83941 tgggttcaag tgattctcct gcctcagcct cctgagtgga tgggattaca ggcatgcacc 84001 accatgccca gctaattttg tatttttagt agagacgagg tttctccacg ttggccaggc 84061 tggtctcaaa ctcttaacct caggtgatcc acccgtcttg gcctcccaaa gtgctgcgat 84121 tacaggtgtg agccaccgcg cccagcccac aatggccttt tgtttacatc tctagtgcag 84181 cactcatttc atgttctttc aagaagaata catatttcat ctttttattt tatacagcaa 84241 ttagcacagt gcctggcata aggaaaatga tcattaaaag ctgggtgaaa aacctaataa 84301 agctactgag gataggaact gcagaccagc atggaaagaa aactatgagc cagatattga 84361 catcatcctg aaaggcagaa gatttagtat aggcaagaag tatgcttttg gaatatagaa 84421 aatctggatt atgataagaa aagaatcata tttgtcttat cttacctact cacttctcag 84481 ttccacatgt ttctgaggct gtttgtcctt actttctttt ctgttttatc cactctttct 84541 gttctttaga ttggatcatt cctattgagc tgacatcaag ttaactgacc ttttattttg 84601 tccaaactgc tgttaaatgc atccagtgaa tttttaactt tatatagtat atcttttagt 84661 cctagaattt ccacatgagt tttttaagtt tccatttctc tgctgagatc tcctatttgt 84721 tcattcatta tgaccatatt tttctctaca ttattgagca taattataac agctcttcta 84781 aaattcttgt ctgcacattc taacacctga attattctgg ggtcagtctc tgttacattg 84841 ccttattaca aaaacagtat aagtcacatt gccttgtttc ttaatatgca aaatgatttt 84901 tgattgcaga ctagacattt tgaattaaac attatagaga ttctggattc tcgagagagt 84961 attgacttgt tttttccatc aggcaggtaa cttgactgga ctcaaactcc aaactctagg 85021 tcctctgtaa tgggcaactg cagtaatctt tgtttagttc tttaagactt attggccagg 85081 cacgggggct catgcctgca atcccagcac tgtgggaggc caaggtggga ggatcacctg 85141 aggtcaggag ttcgagacca gcctggccca catggtgaaa ccctgcctci actaaaaata 85201 caaaaattag ccgggtgtgg tggtgggcgc ctgtagtccc agctactcag aaggctaagg 85261 cagaagaatc acttgaacct ggaaggcaga ggttgcagtg agccgagatt gtgccactat 85321 actccagcct gggtgacaaa agcgagactc cctctcaaaa aaaaatttat tggcactgct 85381 tggcatctgc tatgaataca tgaagttcat gggtcagcta tagatctggg cacgttatac 85441 acagaatttg ggtctccctt tctctggatt tctccttttc tggatttctt ttctcatttt 85501 ccagcagctg tggttgccct aaactcggtc ctctgtttct ttacggcagt aagatttggg 85561 aacttttagg ttttacctgt ctctcagaca aaataaaaaa taattttcat cttgatgcta 85621 ctcctttctt ccagatgtag acacctctct aatttccagt tgctttttat tgctctccag 85681 agtctaaaga ttatcattgt tttctgtggg agagttggtc tgataaaaac tactccccca 85741 aaactggaag ctggaagctt gtaattatga atagactttg agtagtattc ttctttggaa 85801 aaggatttta actactccct atgtacttct ttatttcctg tttttctcat ccgtaatctt 85861. tttattttca tacttcctaa gtcagacaat tttcctactt gaagattcag tgactgctat 85921 caaatgaccc ccatattact aaatacaata tccccaactg catttataaa aagaaaattt 85981 actgtttatt agtaaacaat gttgtagaat agtaaaatat tgctgggctt tggagccaga 86041 taatcaaggt tagaatccca gattctaact tactagctgg tgtattagtc ctttctcatg 86101 ctgctaataa agacataccc cagactggga gactgggtaa tttatgaaga aaagaggttt 86161 aattgactca cagttcagca tggctgggga ggccttagga aacttacagt catggtggca 86221 gcaaggagaa gttccaagca aagagggaaa agccccttat aaaaccatct gatcttatga 86281 gaactcactc actatcacga gaacagcatg agggtaactg ccctcacgtt taattacctt 86341 ccaccagttc ccccccatga cacatgggga ttatgaaagc tataattcaa gatgagattt 86401 gggtggagaa atagccaaac catataattc cacccctggc ccctctcaaa tctcatgtcc WO 00/09525 PCTIUS99/17712 EPI-109 936 86461 tcacatttca aaactcaatc atgccctccc aactgtcccc caaggtctta actcattcca 86521 gcattaagtc aaaaatccaa gttcaaagtc tcatctgaga caaggcaagt cccttctgcc 86581 tatgagccta taaaatcaaa agcatgttag ttacttccta gatacagtgg gggtacaggc 86641 gttgggtaaa tacactgatt ccaaatggga gaaattgcca aaacaaaaga gttacagacc 86701 ccatgcaagt ccaaaaccca atagggcagt cattaacatt aaagttccaa aatgatctcc 86761 tttgacttca tgtctcacat ccaggtcaca ctgatgcaag aggtgggctt ccaatggcct 86821 tgggcagctc tgcccctgtg gctttgcagg gtatagcctg cttcctgttt gctttttcac 86881 aggctgacat tgagtgtctg tggcttttcc atgagtatgg tgcaagctgt tggtggattt 86941 accattctgg ggtctgggcc aggtgcagtg gctcatgcct gtaatcccag cactttggga 87001 ggctgaggtg ggggatcaca aggtcaggag atcgagacca tcctggctaa cacggtaaaa 87061 cccagtctct gcttaaaaaa tacaaaaaat tagccaggcg tggtggtggg tgcctgtagt 87121 cccagatact tgggaggctg aggcaggaga atggcgtgaa cccaggaggt ggagcttgca 87181 gcgagctgag attgtgccab tgcactccag cctgggcgac agagcaagac tccatcaaaa 87241 aaaaaaacaa aaaaaccatt ctggggtctg gagaatggta gcccttacag caccaccagg 87301 cagtgcccca gtggggactc tgtgtggggg ctctgacccc acatttccct tctgcacggc 87361 cctagtagag gttctccatg agggttctac ccctgcagca aacttctgcc tggacatcca 87421 ggcatttcca tacatcctcg gaaatctaag ccgcggaggt tcccaaactt caattcttga 87481 ctcctgtgca cccacaggct caataccaca tgtaagccac caatgcttgg tcagggcttg 87541 aaccctctga agcaatggcc tgagctgtac gttgacacct tttagcctag acatctagga 87601 cacagggcac catgacccga agcttcataa agtgggaggg ccttgggact agctgaggaa 87661 accatttttc catcctaggc ctccaggcct gtgatgggaa gggcagccat gaaggtgcct 87721 gacatgccct ggagacgttt tccccattgt cttggtaact aacattcagc tccgtgtgca 87781 gcaccaactt acttatgcaa atttctgtca ctggtttgaa tttctcccca gaaaacagga 87841 tttttctttt ctattgcatc atcatgctgc aaattttcaa acttttatgc tatgcttcct 87901 gttgaagact ttgcggctta gaaatttctt cccccagata cccaaaatta tctctctcaa 87961 gttcaaagtt ccacagatat ctaggggaca aaatgttgcc agtctctttg catagcaaga 88021 gtgaccttta ctccagttcc caacaagttt ctcatctcca tatgagacca tctcagcttg 88081 gacttagttg tccatgttac tatcaacatt ttggtcaaag ccattcaaca agtctctatg 88141 aagtttcaaa cttccccatg ttttcctgtc tictaatagc cctccaaatt tttccaacct 88201 ctgtctgtta cccagttcta aagtcacttc tacatttttg ggtatcttta cagcagtggc 88261 actccccatg gtactaattt actgtattag tctgttctca tgctgctaat aaagacttac 88321 tcgagactgg gtaatttata aagaacagag gttcaactgg ctcacagttc agcatggctg 88381 ggaggcctca ggaaacttac aaacatggtg gcagcaaaga gaagttccaa gcaaagaggg 88441 aaaagcccct tataaaacca tcagatcttg tgagaattca ctatcatgaa aatagcatga 88501 gggtaactgc ccccatgatt aatttacctc ccacagggtc cctcccatga caggtgggga 88561 ttatgggaac tacaattcaa gatgagattt gggtggggac acagccatac catgccagct 88621 agagagcctt aagaaagtca cctaatctcc acaaataaaa ggtttcctat ttgttcaaca 88681 aaaataatga cacccctttt atgggatttc tgtgaggaca aatgataact aacatagcct 88741 tgcatagtgt ctggcacaaa atagctactc aaaaaataat agaaacaaca tttaaaaaat 88801 gtagacttta ttttttagag ttttatgtac aaagcaaaat tgagcagaat gtacagagag 88861 tttccgtata gcactcccta cccccaagca cagatagcct cccccagtat cagcatcccg 88921 caccagagtg gtacatttat tataactgat gaatctatat tgacgtgtca ttttcatcca 88981 aaatccatag tttatattag ggatgcctct tggtgttgta ccttctatgg gttttgacaa 89041 atgtataatg acatgtattc accattacag tatcataaag aatagtttca ctgtcctaaa 89101 aatctttgat cttcttccta ttcatcactc cctccccatt aatccctgac aactactgct 89161 aattttcctg tctccattgt tttgtctttt cctgaatgtc atatagttta aatatacagt 89221 atgtaggatt ttcaaactgg tttatttcac ttagtaatat gcatttgatg ttcttccata 89281 tcttttcaaa gcttcatagt tcaatattta tagaattgaa taatattcca ttgtctggat 89341 gtactacagt ttatgtattc attcacctat caaagaacac cttggttgct tccaagtttc 89401 aacaatcatg agtaaagctg ctataaacat ctatgtacat gtttttttgt gaattgaaca 89461 ttttcagctt ttttagctcc attcctagga gtgcaattgc tggattgtat gataagggta 89521 tgtttagtgt tgtaagaaac tgccacgctc ttcctaactg gatgtactgt tttgcattct 89581 caccagcaat gaaagagttc ctgttgctcc acatactcac cagcatttgg tgtcgtcaat 89641 gttttgagca atagcatttt gatctaactt ttcctaggta ttctttttga aggaaataat 89701 atgacagata atagagaaag gatatacgag gacagttctg tcctttattt atagtccatc 89761 atttaatgaa ggactctgtc cacacttggt atttttaact ctgatcctcc tctcccatga 89821 actctgacaa tctcctaaat ccctgttgct ggcacacatg gttgtgtatc aggccccctg 89881 tggtctgtct gaagcatggc tttttttttt tttttttttt tttttttgag acggagtctc 89941 gctctgtcgc ccaggctgga gtgcagtggc gcgatctcgg ctcactgcaa gctccgcctc 90001 ccgggttcac gccattctcc tgcctcagcc tcccgagtag ctgggactac aggcgcccgc 90061 caccacgcct ggctaatttt ttgtattttt agtagaggcg gggtttcact gtgttagcca 90121 ggatggtctc gatctcctga ccttgtgatc cgcccgcctc tgcctcccaa agtgctggga 90181 ttacaggcgt gagccaccgc gcccggcctt tttttttttt tttttttttt tttgagatgg 90241 agtctgtcac tctgtcaccc aggctggtgc agtgatgcaa tcttggctca ctacaacctc 90301 catctttcag gttcaagtga ttctgccacc tcagcctccc aagtacctgg gattacaggt 90361. gcccgccacc acacccagct atttttttgt atttttagta gagacqtagt ttcaccatgt 90421 tggccaggct ggtctcattc ctgaccttga gtgatccacc tgccttggcc tcccaaagtg 90481 ctgggattac aggcatgggt catcacatgt ggcctgaagc atgactgttg ctttaatcat 90541 atgaaatact gctctgtatt gttatctatt tgaaatgcca cacctcctga gctaaattgc 90601 aagcttttat ggagcacaaa ccatatttat atatattagc atgataccat gacacatatc 90661 aaaagctgtt atatattgtt acgtgaattg attctttctc agttaagagg acctctgtag 90721 tagcactttc ataccgttaa tttttcattt tgtgcccagc ccctactctg tgaaaaatga 90781 aatgaatcct gttatcattt ccctcccagg ccttttctcc ttgtggacaa tgtgtggctc 90841 aagagaaaat tcagtcagta aatttgttca gtgcacaaac tctttatcac ctctcactgt 90901 tctcaagtga gatagaacag aacatccatc cagtgtctta caaattgtct ggtatatagt WO 00/09525 PCT/US99/17712 EPI-109 937 90961 aggcactcaa taaatgtttt ttgaataaat gcatacatga atcctattcc tatatatagt 91021 atggtagaca gatcattgat acccaaagat gcccaaatgc tgatccccag aacttgtgaa 91081 tatgttacat ttcatgtcaa aagggacttt gctaatgtga ttaaggattc agacccttgg 91141 attgtaagat tatcccggat taaccagggc caatctaatc acatgagacc ttaaaaaagc 91201 agaaaacatt tcccagctgg gttagagaga gatgagacag agtaaaaagg aaagagattc 91261 agggcatgaa aatgactcta cccactgttg ctggctttga agatagagga actaggccac 91321 aaaacaagga gtatgagtgg ccttaagaaa taggaaaaag ccctcatctg acagccagct 91381 agaaagcagt cctctgacca caagaaattg gattctgcca accactcaaa tgagcaagga 91441 aatggattct cccctagaac ctccagaaag gaacacagct ctgtaatgcc ttgattttag 91501 ccaggtgaga cctgtttcag acttttgacc tatggaaata taagataata aagttttatt 91561 gtatgctgct aaatttgcgg tagtttatta ctgaagcaat ggaaagccaa tacagacaga 91621 atatacagag agaaagagaa tgagttcttt cctgataatt tgtaaatatt tgggtcttca 91681 ctggacaagc ttcacagagg attcactggt tccctagcaa accagcatgt ccagtcctgc 91741 agcctccctt tcttaggccc agcatatgtc agctgtgtgc atagaaaaat caaagcagga 91801 ccctgagtag ttggaaagaa aagatggttg gaaatgggtt gcacttcaag tgaggaaaca 91861 agaggtagga gaccggcatc tctttctcat atgtcccagg ctgactcttg tgagttgttt 91921 tcccttggag gctatcgatg acagtcacag taacctgatg gaacctggat catgatgaaa 91981 gaagtaagtg tcaatggctc cgacttccaa ggactctgat gtcccacagc actagctaaa 92041 caaagccagt tggaaatgag cttaaatggg gaatttcctg aatatattcc ctattgttag 92101 gaagccaggt tggcttcctt gcctacaatt atgccaagca gtcacactat agagtcccta 92161 gggacatgat attaagtgat tcttttaaca caaacaactt aataatcatt tatactaata 92221 gcaaaacggc caacggctga tattccactt gaagtagaat tggctatcca actggaagag 92281 aagacaggaa gacgtgatct ccagggagcc actaaaagga ttggcacctg cctctggatt 92341 ccccttttcc ttatattacc tctcagcact ggcaggcctt tatttcagga tacagtttca 92401 caagtattat gtcacgtctc tgagaattat gttggtagat atttgctcct ctggccagaa 92461 agacctagtt tggagtctgg agtcatgaag gtgacataca tgtagctagt gacataagtg 92521 tagctagtaa aaatagtgag taatggccct gaaattctat tgaatgccca aagtgctgac 92581 caggaacaag catgctctag cttatctcac aaggaacttg acaattttct tcaaaaatcc 92641 tagtagctaa gatttcttag taacaaagcc actaaggcac aattatgatt aacttgaccc 92701 ttaggtgact tttaaggact attctataaa atattacaac taatagtgga tccaagccag 92761 cacactctgc tatataagat taattgacag tgtccacact ggtaaaataa gttgtttcat 92821 aaatacatta gaattcattt gcactttcta cacagcccca agtccagaac tttccccaga 92881 ataggtctat gttttgcaat ctgctactcc atacagagat ttgagttcac ttggcaattt 92941 agtgctgctt atatgtgacc agttagtctg ttttacttat ctatgcctta aacattacta 93001 tacttactaa ctccaagatg cctggtctca acttgacaaa aataccccaa gttgggaaat 93061 ccttatgtga atatgtagat agtcacaatt gctggttgat gatgatctgt cttttcctgt 93121 atttgagaaa atggagataa aatggaccaa tccaaataat ggattaaaca tgggaatagg 93181 tgagagagag agaggaatac atggtggctc tcagtgtctg gcttaggcag taaacacttt 93241 cgttaataaa gacggaaaat aaaaaaggaa taattggtgt ctaggggaaa ataatgagct 93301 caagttttaa cactctgagt tcccggatgt gagacatcca ggcgcattta tccaagaggc 93361 agttggaagc aacgttccgg agcttaggag agaggcatga ccaaaagctg gtgggactgt 93421 gaaaaggtat ggccattctg gaaaactgtt tggcagtttc ttagaaaatt aaacatgtac 93481 taacaaccca gcaattgtac tcttgagcat ttgtcccaga taaatgaaaa aaaaaaaaag 93541 catttttttt acacaaaaac atatacatga aagttcatag aagtgttatt cataaaaaac 93601 tggaaaaaac tgagatgtct ttattgagtg aatgcttagg caaacggtgg tctatccata 93661 caatggaatt atgcttagca ataaagagaa aagaactatt gatacatgca ataacacaga 93721 tgaatctcaa aggaattaat gctgagtggg aaaaaaagca catctcaaaa tggtatatac 93781 tgtactattt tatttactta acattttaaa aatagcaaaa tcatagagat ggagaacaga 93841 ttaatgggta ctgtgttttg ggatggggag tgagaaaagg gtaaggtgta aatataaagg 93901 ggtagcacaa aagagccttg tggttgaagg attctatgtc ttggttgtag tcgtgattgc 93961 aggaatctac atgtgataaa attgtatggg tctacatacg catacacaca agagcatata 94021 aaactggtga catgtgaaga agctccgcac attgtgccaa catcagtatc ctagtttcaa 94081 tatcagacta cagttataca aaacattgtc attgagggaa actgggtaaa gggaacacag 94141 gacatttggc atatattttt gcaatttcct gtgaatccgt aattatttaa aaataacaga 94201 tatactacat atcaaaaatt taatgtcata aagttgatga gtttacctag tggatagctt 94261 tgttaatatc tgctataaga ctactgaaaa tgacagttat gcaagtataa gctcagagaa 94321 ctttcctccc ccttcgtaaa tgaaatgagc aaaagaaatg aaacaggaaa ggcaagcagt 94381 actgaaaaca gggaagggct cttccccata taactatatc tgcgacttca acagctattc 94441 atccagaaac acagcctctt gcgctaagag gaaactttgg ataacaatat gttttcactc 94501 tccaagagag aaaatggata gattaatttt taagaaaaaa aaaaaaacct caccaatttc 94561 atgctgtggc ttgcaccttt aatcccagct acctacaagg ctgaggtgag aggcttactt 94621 gagcccagga gttcaaggct gcaatgagct atgattgatt gtgctatcgc actccaacct 94681 ggagtactaa gctaagagct aagaacacag ctgagagcgg agaagaaaca aacaaatctg 94741 accaataacc cccactcccc tcattttact ggagtgagct gagactgctg gcaaacatgg 94801 cctttgacct agcctgaact gtagcaaaag tcatcagata tttttccacc aatcaacaga 94861 cagaagtggg gagaaaacaa tcgtagttca taactacaac aagcagataa acgaaggcca 94921 tggtgaggga tggaagacat tgtgatatat caaaggcagg ctcatttaaa actcaaccca 94981 aattccaaac aaaatatata attgaatatg tattaatgcc aaaggagctt gagtgagctt 95041 tagcacaaac cccgccctcc agcccccacc caaaaaaatc actctgttct ctccccattc 95101 tttgataggc atacttgctg ttttctcaca gccaaggtac agaggggact tagaggaact 95161 agaactctaa tacactgcta gcaggaatgt aaaatgaagc atctacttca gaaaaccatt 95221 ttatcagttt ctagaaagtt aaacatagac ccaccatgca gcccagccac tctactccta 95281 agtatttaca caagagaaat gaaaacgtgt ccccacacag ttgtatttaa aggtgatggt 95341 tagccttgtg tgtcaacttg gctaggctat aatacccagt tactgaatca aatagtaatc 95401 taggtgcatc tgtgaaggta tcttgtagat gtggttaaca gctacaatct gttgacttca WO 00/09525 PCT/US99/17712 EPI-109 938 95461 agtaaaggag attgctcttg atagtatggg tgggcttcat ccaatcaatt gaaggcctta 95521 agagcaaaaa gtaaggtttc ccggagagaa agaaatcctg cctcaagact gcagcctcaa 95581 ctcctgcctg agtttccagt cagccagcca gcctaaagat ttgctaggca ttataatcac 95641 atcagctaat ttcttaaaat aaacctcttt atatatattg atacaatgaa tggttatagc 95701 agccttattt gtaatagcca caaactggaa acaacctaaa tgtccttcaa taagtgaata 95761 cataaacaaa ttgtggtata tccacaattt ttacgcagca gtaaaaagga ataaatggtt 95821 gaataaggaa taaacacata acaaggatga accttaaaac cgtaaggctg aatggaaaaa 95881 gtcagacaaa actaatacat actgaataat tccatttata ttgaagttct agaaaatgag 95941 gactaaccta tagtaacaaa aagcagaaaa attttgccca ctggtgatgg agggggcgca 96001 ggtattgtag agtatctgag aaaggacaac tggataaaag ggggcacaag aaaacttttg 96061 agggtgattg atatgttcat tatcttgtgg catggtttca taggtgcata catatgtcaa 96121 aacatcaagt tatacacttt taaaatgttc agtttactgt atatctatta tacttcagta 96181 gagaggaagg aagaaagtgg gcagggtggg ggagaggaaa ggaaacgagg gaggaaaggc 96241 cctaatagga aggattttgg agtttagatt ttaaaatgat aaaggatgtt tgacactcta 96301 ggcatatgac gaatatagga ttatgagtcc acaaaaacca ccaggaagtc atgtatgttt 96361 atacttttaa gtgaaggatc agtggattat caactcccta atgctttgcc tctctatgac 96421 tggctgctgt ccttctcatc ccaatactcc ttccaaagcc ccttgcttaa atgtaagcct 96481 tctttcctcc tttcaacaca tcctgcattc cgtgacaaaa taagttttcc ttaaacagaa 96541 tgtacagcat attatttgta caattaaaaa tttttggcca ggtgtgatga ctcatgcctg 96601 taatcccagc aatttgggag gccgagatgt gtggattacc tgaggtcagg agttcgagac 96661 cagcctggcc aacatggtga aaccctgtct ctactaaaaa tacaaaaatt agctgagtgt 96721 agtgtggcag gtacctgtaa tcccagctac tcaggaagct gaggcaggag aatcgcttga 96781 acctgggagg tggaggttgc tgtgagcaga gatcagacta ttgcattcta ggctaggaga 96841 cagagtgaga ctcggtcccc aaaaaaaaac acattttttt ttaatgtttc ctccttgcct 96901 gtaggaaaaa ggctctgact ccttagcctg ggcatcagag ctctatctaa atggacttta 96961 acctgatttt gtggcactaa ttccattgca gtacttgtcc gctcactggc ctgtgcctct 97021 ctgccactat ttttggaata atgtcctctc tccatcttgt ttactcaact atatccaacc 97081 tctaaggctg tgctcctaca aagcctcccc tggctacttc agcccacaga gatatttaac 97141 tgctctgcag ttcaggacat tcttctgact ctttaaatca catttactta tatatgatct 97201 tgtgatattt tttgttgacg tgtttacttt aattttcttc cataacctat tcattcaaca 97261 aactcaacaa ttatttatta aatgccaagt tagaaaaata ttattgattt tatatagatt 97321 atagatatgt ttgaaatttt atttggcaat ctgcaagtag aaaaataatt ataatgtggt 97381 atatctgtga tagaagtatt agtgcagaga ccatggggaa cataatccag cctggaagtt 97441 caggagagat acgtggaaga aaggacgtca gagccttttt cctacaggca tggaagaaac 97501 attaaaaaaa attttttttt ttgagatgga gtctcactct gtctcccagc ctagactgtg 97561 gtggtgcgat ctctgctcac tgcaacctct gtctcccggg ttcaagtgat tctcctgcct 97621 cagcttccca agtagctggg attacaggta cctgccacac atggatgata aatatgatca 97681 tattttcttg ttcttttcct cctcagttgt cttccctgaa gaaaggaatg ccttttatag 97741 atgacaaact cccattctca agaacaagga tttttgacca atttaattta atcagatgtc 97801 tggctttgac ctagaaacac agtcacgaaa cttggtgatt agagaccaat tcccaaacat 97861 gagcatttct taggaaacac agtaaagatc tgagagaccc aagagcagaa gggcgagaaa 97921 ccaaaagcca tcagtttgca taggaaacac cttgtttagc ctaatctttt tatttttatt 97981 actctattag tcactacaac tattttctga ttgctatggt gatagatggt ttaaaacaag 98041 ccttcattaa gaattgtcac accatggtct cagtcaaaaa caccaacatt tttattggta 98101 ttgacaatta tgggaatatc caattccaag aagacaagga gacctctgaa ctttctaaat 98161 gaagactcca atcttcctga tctgatggga agcagcttgg caagattacc aaccaccacc 98221 acagagagtg gactctaagc taagacttaa aagataagta gaaattatcc aggtaaagat 98281 gtgtacagag aaggaagtac atccagggga aaagaacaat acgtgcaaaa gtacggaaat 98341 ggtaaaaagt aatactacat agtcaaagcc aagcagagtt cagaagggat ctggtggtga 98401 aaaatacggc tagagaaagc agcaaggatt ggcttctaaa acctatgtag tatcttggac 98461 cttaccctaa atgtaatgag aagcttctaa agaatctttc atttattcat tcattgaaca 98521 aatattttga ggctttctgt gaagaacatc attctaagta gtaaagatac agcagtgaat 98581 aggacacata aaatcctaga tctcacagaa ttgacattcc agagagggaa aggtagacaa 98641 taaatacata aacaaatcat ttaacaagat gatttcagac aatggtacgt actgtgaaaa 98701 aaatgaaaca aggtaatgga cagcgaaaag gcactggaag gaagcctgct tacctttgca 98761 tggttagaaa agatctctct aagaaagaga ccacatgtga gctgcgacct gaaggatacc 98821 gagaagctag gtgtgcaaag atgtggggac agaacttttg gactgaatag caaatacaaa 98881 tgcccttggg tgcaagcttt gcctgttcaa ggaccaaaaa gaaggccagt gtgcctgcag 98941 catactaagc acagaggaaa acactgttat atgctgagat tggaattata agtagagcca 99001 gataatatag tctcttatag gtcataataa ggcaaccaga ttttattcca agaggattta 99061 aaaatcactg gaggttttgc actagggtga gaggtgtgat ttgtattttt aaaagataat 99121 tctggagaat taactataat gaggtaggag taaactaagt taggggctat ttcagtggct 99181 cagacaagag ataatggtag cttagactag gatagtagtc gtagaaataa ataaaagtgg 99241 cactctactt tgggggtaga gtctataata ggtttggttt atggatcata tatgagagta 99301 aaaaaaagaa aataaattaa taatggttcc taggtttgta cctgagcaac tgaataaatg 99361 ggtgctgtga attgagataa aggagattga gaatcacagg ctttgttttg caaattaatt 99421 ttgagaggct tattagacat cccagtggag atttcaggtg agtggagccc attgaaaggt 99481 aagggacagg gtcaggtgtg gtaggtcagg cctgtgatcc caggactttg gaaggccaag 99541 gcagacagat cagttgagct caggagtttg agaccagcct gggcaacatg ggaaaaccct 99601 gtctctacaa aatatgcaaa atattacctg ggcatggtgg catatgactg tggtccaagc 99661 cacttggggg gctgagatgg gaggatcact tgagtacagg aggcggaggt tgcagtgagc 99721 caagatctcg ccactgcaaa ccagcttagg tgacagagtg agaacctgtc tcaataaata 99781 aataagaaac gtaagggaaa aggaaattaa tctgatcatt ggcaaatgca tagtatttaa 99841 agccagggga gtagatgaga tactcaaagt aggtgaagat aaggaggcaa tgaaggccta 99901 ggactctggt gtacatttag atggttataa gaggaataga aactggcaaa ataagtaaca WO 00/09525 PCTIUS99/17712 EPI-109 939 99961 ctgagcaccc aatgaggtgg agaggaaagc caggagatga agcatcatag aaggcaagag 100021 aagaagggtg tcaaagaggc gaggcagtca tcaacttctg ggcagtcaaa taatataagg 100081 acagaaaagt gaccattgga tttggaaata tgatgagcac tttgagtgga gtgttgagac 100141 agaagaccaa ttagagtaga ttgaggagat aacgagaaat gagaaaatgt aacctgcaag 100201 cacagacaat tcttgagaga cttttctgtg aaaggaaaca gacacagagt cttagcatgt 100261 cttgtctttc tatgggaaat gtaaatagtt tgagatcagg gatagtattt tattctgctt 100321 tttgtacctc tacattacct agcatagagc tagctaatgt gcacttaagt atgttctcaa 100381 ttcttatcgc ctgaatgact ggatgggtga aagaatggat ggatggatgg atggatggat 100441 ggaaggatgg atggatggat ggaagacttc tgatttgcca agaagaggat actggtagca 100501 gaaataaaaa cagcactgga gaaagaagag tttagatttt tattctttgg tgtcagttag 100561 acaggaaagt aagacattag aagagtcctt agataattta tgtaattgtt cacttaggat 100621 ttttaaatgt gatcactgat attggacatg ttcctagtga agcatttttg gtgtttcact 100681 ggttgaagtt aataactgta aaattatttc ccgttcagga cagaaaaaca gaaaacttga 100741 agctcctatt agaaagttca agattctctg gggttcttag gatttactgt tcccaaaact 100801 ctgtcaagaa caagaaaatg acctgtatac ttaactggtc taggcaacag tggaaagaca 100861 attctcagag aagatttgtt ttaagaagac actttccata ggaatcaaac aatagctttc 100921 agtgactaac atggtaagac acagggtgtt agctctttcc ttccaacctc atggctgttg 100981 taccttacct ttcqaccccg tgttcctgaa attgttaaat tcataaactt accaaggact 101041 aaccagcctc tggggaattg ctgtatactt agcaaactta caatggacat atttataagc 101101 cataatgata actgactaat aggaaatacc ctcaactgaa aatgagagat catcatttgc 101161 aaatgagttc ccttgcccag gcaactactg gggaaaatgt catgcaagca aaattaatct 101221 ttgaaatcct ccttttccat tttttgtgtc ttccttttcc ataggcacca gaaatatcat 101281 ggtgcctgga tctcatctct acagaaaaaa aaagtgattt gataaactga tttatattgt 101341 gtccaaatgt gattgtattt tcaaagataa cctaagggga gaatgctgtc tggcccaaca 101401 gcaggctctc gacttcattt cagacactgt ggccaatggc tgggaaacag gtatgaacag 101461 taggtttctg agtcccctgg aattattcca tttatgtagc cacctccatg acaggaagcc 101521 tccctactct tacttcccag tttgttcatt catggcacca ggttgcagat taaaatttgc 101581 tcagtgacct tttatctaat aatgtgttac cttcttctct taaaaagtac aagggacaaa 101641 tgctcatggt atacttttag gagattgtgg ctctctatta acagtattta ttcaacaaac 101701 atttattgag catttatatg tgcatcatgc tagggactgg aacctagtaa gtgtagcaca 101761 tattatttca tttaatcctc acaacaaacc catgaggttg gttttatgat cccaattttt 101821 cagaagaaga aactgatatt cagaaccagt taactaactg gttcaaggtc atgcaatttc 101881 taagatacag aaccaagagt caaagacatg attttaaacc aaagcttttt ctgctactcc 101941 acattgcttc cctaggtgag atctgaggca ttccgcgaaa agagaagggt cataaagcca 102001 agggaagaca agcttaggaa aaaaaaggga aatgtcctaa ataaacagct ttcctattta 102061 ccagaaacca ctagtttaaa aatataatgg gaaaaatcct attcacttta acaatgttaa 102121 aaaaaaaaaa gatagaaga' acatagggat aaacttaaca catttgtagg atatgtaaag 102181 aaactaaaag atgttaataa tggcctaaag aaaaaaaaac ttacatgtat ggggagatag 102241 accatcttac tggattctaa tatttaatag tctaggtgtt ccatttctca ccaaattaat 102301 gtatacattt aatacaatgt caaacgaaat atcttaggaa ttgcttacaa attgtcagat 102361 aattacaaag tttacctggg aaatataagc atatatgaag agtgaatggg accccaccac 102421 tccccccaaa acaaaaaagg tctgaaaagg acagaaatca aggagagtct tgcctgccag 102481 atacaaaatt ctattataaa ggtgtattga tgaaaacaat ttaatactag tgtagcaata 102541 ggcagcaaag caatgaaaca gcataaaaag accagaacta tacctaatta tgatgaagat 102601 ttaaggtatg ataaacatga cataattcaa atcagcagaa attggcatag atagggttaa 102661 gacaaatagc taatcattag aggggaggaa ggaaaggagg gaggataaaa ttaggttcct 102721 gccttcatct tacattaaaa taaattccag atgtattaca tttaaatttt tttaaaaaaa 102781 gaaaccacaa aatacttgaa gaaaatataa gttgttatat agtcttttga tgggaatttt 102841 tttttttttc agagacaggg tcttgctctg tcacctagcc tagagtgcaa tggcatgatc 102901 atggctcact gcagccttga actcctgggc tcaagtgatc ctcccagctc agccccccag 102961 gtagcaggaa ctacaggcat gcgacacccc atccaactta ttttttattt tttgtagaga 103021 caggggtctt gctttgtttc ccaggcttat ctcgaacttc tgccttcaag cacctcagcc 103081 tcccaaagag ctgggctgat gggacatttt ttaacatagt gccacattac cataaatgaa 103141 aagcttgtaa aatactaatt tttaaaacta atatatatca gaaattttta taaacaaagt 103201 taaaaagcaa acacaaaaaa tttgtagcac ttatgacaaa tatatgtata tatatgaata 103261 caaaaagagc ctttacaaaa cagtaagaaa acaatgaata ctcccaatgg agtattcaaa 103321 actaaactgc taaaagcaat tcaaaacaaa aaacataaac tatgcatata tgtatgtgaa 103381 aaagtttaac cttatcaaag aagtaaactc tcaaagaaat aaacatcaaa taaggaaata 103441 gccttttccc acaaataacc aaaatctgta agaatactga gctgcgaatg tttcagaaaa 103501 aaaaaaaaat catacaccta gttcggcatg taattaatat agatcagaac actttaaaaa 103561 tatttatagg ccaggcacgg tggctcatgc ctataatccc agcactttgg gaggccaagg 103621 cgggtggatc acctgaagtc aggagtttga gaccatcctg accaacatgg tgaaaccctg 103681 tctctactaa aaatacaaaa actagccagg catgttggcg tatgctggta atcctggcta 103741 ctcgggaggc tgaggcagga gaattgcttg aacccaggag gtggaggttg cagtgagctg 103801 acattgtgcc actgtactcc agcctgggca acaagagcaa aactctgtct caaaaaataa 103861 -taataaataa aaaiaaaata tttatatact ctgacccatc aatttgtcca gcataattag 103921 gcatgtgtac aagggtttac acacaagaat gcctattgca atattgcttt taatgctaaa 103981 aaaaattggg gaaaatgctt taaaaatata gattaagact gtacattgtg gtacagtcat 104041 ataatcaata qtatacagct attatttatt ttcagccact gtccaaaata tagcctggcc 104101 taacaacatt ctgttaggat acgcaagcac cgtgaggaga tcagctataa agtatcagtg 104161 tttcacacca ctgctccttt gctaataacc ttcaatggct tttaaagaag taaaaaacaa 104221 aggcaaaatt ccttagtcag cccttaagac tctctgttac ttagctcaaa ctaccctttt 104281 caacaacact gccctaacca ggatgagttt tttgcccccc tggagtacat tcagcctttc 104341 cttatcaaac cttcctttaa ataagtatct tctccaggac cacttcactt tcttccccaa 104401 tttagcattt tctatatctc caggcctacc tctataaagc ctgtcctaac cactcaaacc WO 00/09525 PCTIUS99/17712 EPI-109 940 104461 ctagcttttt ctctgaactg ctagaaatat ttttctctca ttggccattt aggtaaaaag 104521 gtttttactg tttattacct actcaataaa aattttcttt ttttgagaca aggtcttact 104581 ctgtcgccta gaatgggggg aagtggtgtg atcacaactc actgcagctt ctacctccca 104641 gctcaacagt cctcccacct cagcctagtg agtagctgtg actacaggca tgtgccacca 104701 taccccacta cttttcattt tttatttttt gtgagatgga atctcactat gttacccagg 104761 ctggtctgct gatctcaatt gatcctccca ctgtggcctc ccaaaatgct gggattacag 104821 gcatgagcca caatatctgg ccccagtaag cttttaaggc cattaacatg aggaacagtg 104881 ttctttacac tattttatca gctagggctt tgcatggagt aggagtttag taaatgcggt 104941 tgatgggtta atcaatgtgt gaaaatattc agagccacca aaaacagata ttatgtctat 105001 tctcatcaac aatcaaaatt gagtaaacag ccattttcta atacaggaaa ccacaaaaca 105061 ttgaatggtg acattaaaaa attcccccag caggagccaa ccaatttttt catcctgatc 105121 caagttagca aactgcaaaa gataggaagc actaatgagt ggaaatttga gtagaagcat 105181 ttcttatgaa ggctgtcttg actggatcac atttttattg ctgttggagg tgccaaatgt 105241 gtgtgtttat gctaatcctc cacctcaggc aacacacagt caaggatcct accaagtgtt 105301 accgtcaagt gtctgttggc agctcaaggc cccagcgttg ttcccttgca ctagggaaaa 105361 gacatattcc aggtacaagt actcccactt tgatgctaca gaggagttgc tgaactttgt 105421 gtcattaatc tctcttcgtt agatcccaac cctgtttaaa tcccactatc tgcctactct 105481 gggtcttcac caatttacta gatcatagtt ggagaaaatc tacaaagcct tgctcccttt 105541 agatttaaac aggtctccgt ttaaatttag aattgctaac ttcaagcggg cccttatgcg 105601 acagtatgcc tgtcagtcat actacatttc ctcaattcca ttcatgtgac tgctccatac 105661 ccttccctct ctcttcatac tactattate tcttcccccc tccctcattt ttaactgatg 105721 atcttgtttc ctatttctct gagaaaatag aagccatcaa aagagagttt ccacaaactc 105781 ctactgcctt atctagccct gtaccatata ctttgcattt cctctcatta ccatggatgt 105841 actgcctatc tgtgcttcta tctaaggcta acccttccac ttcagttttg aatattatca 105901 gctcttacca actcaaggcc attgctctag caattctctc attctctctc attttcttcc 105961 atcaagtttt ccttttcttc aattaacaga gtagctccta aagggaaaaa aaagtcttct 106021 ttttcaatgc tcatcatcac tggccatcag agaaatgcaa atcaaaacca caatgagata 106081 tcatctcaca ccagttagaa tggcaatcat taaaaagtca ggaaacaaca ggtgctggag 106141 aggatgtgga gaaataggaa cacttttaca ctgttggtgg gactgtaaac tagttcaacc 106201 attgtggaag acagtgtggc gattcctcag ggatctagaa ttagaaatac catttgaccc 106261 agccatccca ttactgggta tatacccaaa ggattataaa caatgctgct ataaagacac 106321 atgcacacgt atgtttattg tggcactact cacaatagca aagacttgga accaacccaa 106381 acgtccaaca atgatagact ggattaagaa aatgtggcac atatacacca tggaatacta 106441 tgcagccata aaaaatgatg agttcatgtc ctttgtaggg acatggagga agctggaaac 106501 catcactctc agcaaactat cacaaggaca aaaaaccaaa cactgcatgt tctcactcat 106561 aggtgggaat tgaacaatga gaacacttgg acacaggaag gggaacatca cccactgggg 106621 cctgttgtgg gatgagggga gtggggaggg atagcattag gagatatacc taatgttaaa 106681 tgatgagtta atgggtgcag cacaccaaca tagcacatgt atacatatgt aacaaacctg 106741 cacgttgtgc acatgtaccc taaaacttaa agtataataa aaaaatatat atatatatat 106801 aaaacaacta aaaataaatc ttctttttct gcaggatcag tccatcacca cacacacagg 106861 ctgtgtttta tgttgttccc cagcttaaga gatcgttctc cagatcccac tgctccttcc 106921 agttgtcacc tcagttctcc acttcttttt gctgataaac tactctaact agttacatat 106981 gatttctgtc cccaggtccc ctccctcagt tgttttgaac ataatcattt atatcattta 107041 tcattttcac tctaattgca caaccaaaaa ctcccttttt ttttagatgg agtctcactc 107101 tgtcacctag gctggagtgc agtggcatga tctcggctca ctccaacctc cgcctcacgg 107161 gttcaagtga tccccctgcc ttagcctcct gaatagctgg gattatacac atgcaccacc 107221 acacctggct aattgctttg tttttgtttg tgtgtgtgtg tgtttttttt tttttttgga 107281 cagagtctca ctctgttgcc caggctagac tgcagtggca tgatctcagc tcactgcaac 107341 ctccacctcc tgggttcaag cgattctcct gcctcagcct cccgagtagc tgggactaca 107401 ggcatgcacc accatgccag gctaattttt ttgtattttc agtagagacc aggtttcacc 107461 atgttggtca ggctggtctt gaactcctga cctcaaatga tctgcgcacc tggacctccc 107521 aaagtgctgg gattacagac ttgagctact gcgccgggct attttgtgtt tttagtaaag 107581 acggggtttc accatgttgt ccaggctggt ctcaaactcc tgacctcaag tgatccgctc 107641 gcctcaggcc ctcaaagtgc tgggattaca ggagtgagcc accatgcctg gccataaaac 107701 tgccctttgt taatatgact gttggcctgc acattgtcaa atccagtggc attcatctta 107761 ctcggccaac ctacggcatt tgacactgtc tgtctttcct tctgttcctc tatctgtttc 107821 cagtatactg gcctggcttt ctttttacct cttttatatg ctcttccagt ctcaggctcc 107881 tttggggatt tgaaggtatg ttgcattttg ctattcaatg aataatgaca agtaatgatc 107941 acttaagaca ttaagtggtc agttccttta ctaggataaa aataattttc ttcccaacat 108001 ggggcatatt ccatttccag tctgactgtt ctgtgtaatc tttgtattcc ttggcagccc 108061 cttttatatc agttcatcta ctgtgcagga aattggacaa acatttgcac tggtataacc 108121 aaatacagtt gaacttttgg cttgactctt agctgaactc accaaaaata atttctgtaa 108181 gagactgaga cgtctacgag taggtttttc agaattagta aacataaatc aaggatacac 108241 aggtagattt gaatttcaga taaacaacaa atactttttt agtatgtcta ctgaaatatt 108301 tgtatcttat ctggcaattc tacctggtac agaactaatc cattctcttg aaagatcttg 108361 actctgtaat aagttctttg gtgatggaag ggaggtattt ctgtaattag agtcactgtc 108421 ttcctcccag ttttttatcc tggcccagat ctgcaatgaa cacacgacag aatccagggg 108481 ggatgaagat gggtgctttg caggaaaaaa aaattaaaaa catctgaaaa agcttttgta 108541 ctaaaagaat gtgatctaaa aaagaaagca ggagaacttt ctgtctgcac tttacatcag 108601 aacaaccttg gcgtctagaa gctgtgccct gtgggaagtg gtggtgcttg gtaagagatg 108661 ccaggaccag tggtacccac tgggagcact gccaataccc agcaaggagc atgggtgcac 108721 agtaaggcat tgcactgtga ttcagcataa aataacaata agggaacgtc acggagaaaa 108781 ggccagactt cctttgttta gaatgtggga aatgtcttct gaaaaatggt agtaaaaaag 108841 catgcttgga tggtccactc caggcaaaac tgactaatcg ggggtcaggg atacaacccc 108901 tgcatcatat gtttgtttct gttgggctga catgaggttc actgtgacca ctgtggttta WO 00/09525 PCT/US99/17712 EPI-109 941 108961 accccatagt ctcctggaaa tacagccagg tcaagagagc tccacataaa acataatcaa 109021 aaaaataaac tcaagtttcc actgatcagc ttttcacaac tcttatcctt tcactaactt 109081 tggagcaaga tttgagaatt ggatggctat ttgagggcta tttctgcgct ttagttcaat 109141 gttttgttct ttctttatta gagaactatg gttttttatt atatttacac tttaagttct 109201 agggtacatg tgcacaacgt gcagatttgt tacacaggta taaatgtgcc atgttggttt 109261 gctgcaccca tcaactcgtc atttacatta ggtatttctc ctaatgctat ccctccccca 109321 gtcccccacc ccccgacagg ccctggtgtg tgatgttccc cttcctgtgt ccaagtgttc 109381 tgtttatgtg atagattacg tttattgatt tgtgtatgtt gaaccagcct tgcatcacag 109441 tcacttgctt acaagaaaca aacacttcac agatggatca ttatgtgtga taagtgaaat 109501 ccaaggattt atgctcagag gtgggcttaa caggtaggaa gagcagtatt ttccttcaac 109561 catgagtgta tgcaggtttt tcttttcttt tttgagatgg agtctcactc ttttacccag 109621 gctggcgcgc agtggtgcga tcttggctca ctgtaacctc tgccacctgg gttcaagcaa 109681 ttctcctgcc tcagcctccc aagtggctgg gattacaggc acctgccact gtctccggct 109741 aatttttgtc tttttagtag agatggggtt tcaccatctt ggccagcctt gtcttgaact 109801 cctgacctca tgaatcatcc ttctcagcct cccaaagtgc tgggattaca ggcatgagcc 109861 actgcgccca gcccacaggt ttttcaaaga ctaaacttaa aaaaaaaaaa aaaatttccc 109921 aatgaaatat aaaactaaag tgctaaactg tgatagactg ttttacaaga atgccagttt 109981 tcacaagtgt ctatagaaca tgtaatttag ataggtaaqa tgaaattttg ataatatttg 110041 atggcaaatt taaacaggta tacaacaaaa ataaaattct aagcccctca accaactgaa 110101 tggactcctt ctctcagcca aaggaatacc aaagtaaacc tgaaaaacta gttttggcca 110161 ggattggggg taggtggggg aagcccaaca cgactcatta ttctctcctc cctttggaat 110221 tcaggcacaa ctgaatgtca gcattgacac taaaacacag atcttaagac tgacaagcca 110281 gactctttgt agcagagagc caggccctgg aagaaatcaa gttattttat cccaaaaaat 110341 atttctttga tatattttca aatggccctg caaagctgtc tcttgtgggg aaaattgaca 110401 tgctgtacag aatttccttc tctttccaag tttttactga tccaggagag atttaactaa 110461 gaggctagca tgtttttttt tttttttttt tgaggcggag tcttgctctg ttgcccaggc 110521 tggagtgcag tggcgtgatc tcagctcact gcaaccttcg cctcccgggt tcaagcgatt 110581 ctcctgcctc agcttcccga gtagctggga ttacagatcc atgccactat gcccagctaa 110641 tttttgtatt ttttgtagag acagggtttc accatgttgg ccaggctagt attgaactcc 110701 tgacctcgtg atccgcccac ctcggcctcc caaagtgctg gcattacagg cgtgagccac 110761 cgtgcccagc acaagacatt taccgtctat tctctctgaa gctactatct agaggcttca 110821 tcaacataat aagacccttg gtctccacaa ctccttatct tatcctatta gtttctactg 110881 attccaggtc tttagataat aacaactctt tcaaccaatt gccaatcaga aagtctttga 110941 atccacctat gacttaaaag ccccactcct tcaagttatc ccgcctttct ggactgaacc 111001 aatgtacacc ttatatgtgt tgatggatat ctgcctgtaa cttccattcc cctaaaatgt 111061 ataacatcaa gctgtaaccc aaccaccttg ggcacatgtt ttcaggaact catgagactg 111121 tgttgcagac cttggtcact catatttggc tcacagtaaa cttctttaaa tattgtatag 111181 agtttggctt ttttcattga cacaggaaaa ataaagaatt ggaaggtctt tcatcagtca 111241 ctgagccagc ttcatatctg actgaggtca tacagttcag tgatttgtag ctttgctact 111301 tagattgcta tccattatct agaagcatca ggatcacgtg ggacctattg gaaatgcaga 111361 ctttcctcct agaacccagg accttggaat attcttggca catagtaggt gctcaataca 111421 tattgaactc ctaggtgcaa ttcattaatt catgaattaa tgaattaaca cgctctcaaa 111481 gtttagtgct ttttcacaga ctagtctttc tgcctcttaa gcactcagct caccacgctt 111541 ccagtctcac tcccctatta gtctgattaa aatctgctta catgtgagtc tgagatcaag 111601 tgttatctct tctgagaagt cttccctcac tggcccaaag gaatttctcc tctattttag 111661 cactgtccca gttgacttgt cattattcta gtctttttca tattagttgt ttttcatata 111721 tatgttatta aggaaactag tcatttcccc taatagaaca aaattgctgg cctttggggt 111781 tggcaatgga ggggaggctc ttcttgaaaa gggggaagag tgttctccta atatttttct 111841 tacgagattt atgttgctca tctttagcct ttagtccccc attgcctgcc tacagttggc 111901 agagaccatc tgttctctca ctgtcaggaa ctgtctcaat tcttgaagtt cagagtcaaa 111961 aaagaagcaa gttttcctag ctctttgatc aactttcaaa gttttacttc catttgaaaa 112021 tttactaagt caccaggaga tggtttatac tgagaaatat ccactcatac tcttcctctt 112081 caactttctt ccatatacac cctattacag ggatatagtc ttactctata gctcaaaagg 112141 atgaccctat cagaaacctg cacagtatgt aaaacattct caccagaggt tcacttgtgt 112201 atttccaccc tagaatggaa gctctacaaa agcacagaat gtatcatttt aactttagat 112261 tctattttca cacccagtgc ttgacacatg atttgaagtt aatatttatt tatcaagtga 112321 ttgttttaaa atcatgactc actcaacaaa gttataagaa taagaatagt gttacagaat 112381 tggtatacac aagctgacca taatcaacac acctattatc atttttttgc gacaggttct 112441 cgctgtctca ccctggctgg agtggagtgg catgaccacg gttcactgca ggtttgaact 112501 tccaggctca agcaatcctc ccacctcagc ctcccacata gctgagccca caggtgtgtg 112561 ccaccatgtc cagctaactt tttaattctt tgtagagaca gggtcaccct atgttgccca 112621 agctggtctt gaactccttg gctagagaga tcctccctcc aaggtccccc aaaatgctgg 112681 gatctcaggc aagagccacc atgcctggcc ataatcaata cacttttaag aatgctagaa 112741 tgttatatca gatgcatact tcagcactat ctcaagcaaa ctggggtgtg ggttattcta 112801 catataaagt tcagcagtgt tgttccacag tcccaaactc caactgaggt caaatgtagg 112861 gtgcagcaag gtcactgggg ctgtcatcaa gggcctctcc ttgcactctt gccaaccctg 112921 tttcttgatt gtctctacca ccatgagtca ccagcaatct cccacagtca cttgtttaaa 112981 agttcacaag tattgtgtga attgcaggca accccttgac tccctgattg cctggtcttc 113041 ttccttgggc tctaccattt tttttcccca gcactctttc tgctgctcta aattttaatt 113101 catgcaattc catatgtgtt tctctatcat tcttcatctc tttcctctcc cttccatcca 113161 attttgtttg tctgtttgct tgcttgcttg ctttaataca tttctctttt tctgagaagg 113221 cttgagtcca aaactctcag ttacctgttg ttctgtttcc cgttagttaa tctccgaacc 113281 ttcataaatt aaatctgaca aagtcccctg actaacaaag gaaatgcaca agtcacagta 113341 aaaggggcac acacagaaca caaatagacc cagggtcttt tctgttcatc actcagcttt 113401 ttataggaga tccaggagaa atgaagtgga aagggaagtg tgttgagtta ctatacaaca WO 00/09525 PCT/US99/17712 EPI-109 942 113461 caagagtaaa ctttcttata agtggtaatt tttttttaca ggaataattg aaaatggaaa 113521 ttaccttctc tactcatagt aagtactcag tgcgttcttg atgggatgag aatgtgtttg 113581 agctttagtg taaggcagaa ttctgtttag tctgccagta ttggagaaaa ataaaacaca 113641 aagggactga catgtaggaa gtggcacctg ggagggtctc aattcttcct attacaaaaa 113701 tgccccagag aaataaaaag cttgtgtaca tgttgagatg ggagagttct ctggcccccc 113761 tcgcaggatg tgtgacagtg gggtggctct ctgctgcgcc accatgagct caaacccctc 113821 ataggagggg gagcacacag gcaggaaggt gcaggagctg ggcgagctct ttgggctctg 113881 gccccgtggt actgtctaga ggtgggtgcc tgcaactcct gaaagcccaa gtgggcatgt 113941 gttacagtgc actctttcag ctttgctgtc tgcagcttaa gcgttaacca gctcagtttc 114001 ttcttggtac ccaggtcctt gtctggcatc caggaagaat caggttacac atggacttga 114061 aggatgaatg tgggagtttt atggagtggt ggaggtggct ctcagtggga tggatgggga 114121 gctggaaggg ggatggagtg ggaagatgat attctcctgg agtttggctg tccagcagcc 114181 gatctcctct ccagtcgtcc ccagcctctc gacgttcaga tgctcctctt ctctccttct 114241 ctgccatgct gttctgccgt tcatctgcct gtctctctct ggagcctgga atttggggtt 114301 tatatggtac acaataaggg gcatggcagg ccaaaaggga actttttagg tgcaaaaaac 114361 aggaatgcct cttctcactt agggctatag attttcaggc ttgaaggtgg ggcctttacc 114421 agcgaacctg tatttccctg tctcctgtgc atatcaatgt aatcaaatac tgggctgatc 114481 caggatgttt ctttagacca attatgggta aaataattta cattcaggtt tttatatttg 114541 cttttgtcat ttctttttaa gcaatcatgt aaaatatcta tacgacagta atagatgata 114601 gcgaacctaa ttaaaattac cagaaactta agaatctcta atgatttcaa ctgtaactaa 114661 ggttatttct ctttatgttg aacaatgttg ggagataaga cacaagagtt tctgaagtat 114721 ttcagaaaca caaagaggga ggttatataa ataatatttt tttcctactt tgggaaaatg 114781 aaagctagtc acaaagttaa acgagtggtt attttaatat ttaaaataca ggcttggatg 114841 tatttcctgt taaagaaaat aaaatgcaga atattcaaaa cgtctgacca cccttctaag 114901 aaaatgcatc tctgaggtat ttttccttag aagttattgt aaaaatcctg gagaagcttg 114961 aacacagcaa agcaaacagg atgcagagtt taatctgtgg aaagcttagg gaagaaaagc 115021 aaatcattaa aaataggtct tcctctgaag atttttaaaa cgcaaagagg gtggaatagc 115081 aatgataata aaaaagctgg catagagagt ggcacaattt gctgtgccac tgagctgact 115141 ggatgtgttc tgaatttcta ggcattagtg tacctttcca cacgcattct cctttaaaa 115201 aaaatgccca cacactgaat acttttttca tgcaatttaa aataagcgca ccatctagtt 115261 tacagaaatt cactagaagt tatttatcct aaaatagcag agatctagaa gaattttgag 115321 ctctaggaca ttttagacac acagaaagaa gaatctggac aagtcttgac cagacatgac 115381 agaatagaaa tttcttttcc tatttatctc tttgaataaa attttcagga tcttacagtg 115441 gacaagtttg ttatctacac attgtgaagc acattgattt ctcctctgta gccttaqgaa 115501 gatctgagag gtgactgagc tgattgaatg atccgtgacc gctctactgg gaccagtagt 115561 agaactttac tggtggagac ctgctggagg tttgagagca gactttgaaa attactagag 115621 ctacacagat actgtgtggc taactggatt atgtttagag gctttcagaa ctatgctgct 115681 gctgctgcag tgtagccagg acgcacagag aacatctaag gctcttgaat ggggcgatag 115741 ggacagattt cagcagccat ctgacttcag tgctcatttt gatgctttcc ctgcagggtg 115801 cagtgtgcag tgtgcagtgt gcagtggtgg gaggctcaca caggaatact tgcttctgta 115861 gccctaattt ccggttcaaa ctctgcattc accttgacag attctttcct tggccaaaat 115921 ttagttaggc ttctgggctt tctcttatgc ccacctgcag actttttggt aaaatccagt 115981 tttagtaaag agctctgcta agtcagttta gcaagaatcc ccacctcaaa agtcactatc 116041 tccctccctg gtagtgtctg gcttgtcttc agcgagaatt ctattaggtt ctgttagatt 116101 agaatcctcc ttacccttga tgcttcctct tagtattttt tcatccactg actccttgac 116161 ccaccttgct cctcggctat aaattcccac ttgcccatac tctgcagtta agactatttt 116221 ctccccacta ctgcaaaatc ccattgccat ggtccctata ctatctcaat ggtaatgaat 116281 aaagtctgcc ttaccatgct ttaacaagta acattgaacc atttttttct ttaacaatct 116341 gctgcacaat gagattacta aaactttatt ccattttgcc atgctggatg tcctcaatgg 116401 aatggctctt gtgagcacca aatcattgtg agaaggaaaa cccatctctt acagccccct 116461 gtaacgtgat gtatgttaca tgtgatgtat gttacatagt tttttttcat gttgatcact 116521 ttttgcccat tttcctatat cttatcagtt ggaagactgt ggaagtttgt agtactaagc 116581 cacaagatga ctaagaagag ttgaaagggc aagtggggct aaaaacagat tttgtttgac 116641 ttaccccacc attcccccta tcatggggct gaatctgcct ggaggaagga gcatctttat 116701 ctttgtactg tgaaccacac agtctagcag cagcacagcc aaggcacttg gggtttcatg 116761 agactaagta catgcaattc tattgtaaag gcttaaaata tatacaactg acccttgaac 116821 aacatgaatt tgaattgcat ggtcagttat acgcagattt tcttccacct ctgccacccc 116881 tgagacagta agatcaatca atcctcttcc tcctactcct cagtctactc aaagatactt 116941 gaagtctact tgaagatgac aagcacaaag acatttatga tgatccactt ccacttagtg 117001 aatagtaaat atgttttctc ttcctcctaa ttttttaaca ctttcttctc tctagcttaa 117061 tttattgtta agaatacaat ctataataca tatgacatac aaaatatgtc ttagttgact 117121 gtttatgtta tctgtaaggc ttcaggtcaa gagtatgcta ttagtggtta agttttcgag 117181 gagtcaaaag gtgtatgtgg actttcaact gcaggggggt gggcacccct gcccccatgt 117241 tgttcaaggg tcaactttac tgccaaaggc aagcctttac atccactttt tccatcccat 117301 cagtaaatgg aaaaagatag ctacagtatc cctgcgtcaa atcttttttt ttgcagatca 117361 caaattggcc actcaccttg ctctgtgagg ggtaaaatgc cccactttct ttagtaatat 117421 ttaagttaga taatatttaa gttataaagt tgttctttgt aatcgttaat tgtaattttt 117481 acatagtttc tttcaaacag aaatagcatt tttgttagat aacctcccgt atagatgatg 117541 aaactccttt taagggctat ctgaatttta attccttgaa aaggcagaaa ttggatagct 117601 agtagtcata aatgtactgt ggcttccccc aaccatctgg gctatataga agctgcatcc 117661 ttggactgca gtagaggagt cttacaaagc acagagcaac ttctctcctg ggttgcgcta 117721 gttatgatgg caattttaaa tgtgtacttt tacccaaaga aaatccttat tatcaacaat 117781 cacaatgcca tcataaccat ggtataaaaa attcaaaatg tcccagctga agtggaggca 117841 aagactcaag ttcatggagt cagagtttcc ttgctattcc tctttttcaa atgaccattt 117901 agtaagcacc tgaagaaaat actatggacg gcattgaaaa gtgaagatag gtttaatctt WO 00/09525 PCT/US99/17712 EPI-109 943 117961 ctcgaaaatc taattctcca gatgaaacgc tgacacttat ccaccccaca gaccctatag 118021 cagatgtgtc actggccatc acatttgaca cagagaagtc ataactcagt cagcacagag 118081 acatttccat gagtttctga accatggaca gaacgtcgtc tgtgggacat gaaaactgga 118141 acttagagga caggcacatc tgagaaatgg gcagtttaaa ggcagaacat agcacatatg 118201 tgactgggtt ttagaagcaa atttacaaga cgcactcttc ttcatcczaa ataatctgca 118261 accaaagctt ccaaaaaaga caatttagga atgcagaggt gaggagtagg gaggggaatg 118321 ggatgagaga gagtggagat taatggtggg cagagcgagg tttagaactt agtggtttct 118381 tcaggttctg aactgaaatt tgtatactgt aaaggcacaa acaccatttt taacaaaagt 118441 gagcaggact tcctatctgg ttcagaaaat aggtgaataa atagtacgaa ttattaaaaa 118501 taataatttc cacttataca taggaaactt gataggaacc atgataaatg cttaactctt 118561 aatcttcaag gaactctgct agggatataa tattataaat cttgttttgc agatggagaa 118621 attgaatttt aacccaagtt atcataaccc ttaaatgatt aaatgatact gttacatgag 118681 aaagctgcgt atctgtttcc tggatttgta gccataattt gtgtctcaag tcccttttgc 118741 tgccagctat cttgggtagg tgtgttccct ttgggctgtt tgataccccc acatttatct 118801 tttttttttc tctttttttg ttgagagagt ctttccctgt tgcctaggct ggagggcaat 118861 ggcgcgatct cggctcactg caacctccgc ctcctgggtt caagtgcttc tcacgattct 118921 cttgtcccag cctctctaat agctcggatt actggcatgc accaccacgc ccacctaatt 118981 ttgtattttt agtagacaag gggtttctcc atgttggtca gggtggtctc aaactcctga 119041 cctcaggtga tctgcctgcc ttggcctccc aaagtgctgg gattacaggt gtgagccacc 119101 atgcctggcc ccaaatttat ctttaatgcc ccaaattatc tagttcccat gactgggctt 119161 ctgctttgat cctttctgca cttgctggac cctctccctg ggaaatgaga ttgtgtcctg 119221 agcccctagt tagaggctat gtctctgctg ttcctgaatg ggcctcctgg atgagacctc 119281 attaaaagtc taattctctt ggagaattga gagataccta tttgtctcaa aatcattgaa 119341 accaattaat gtattatgag cctctatcca gtgatttgta cctcaattcc ccaatccagc 119401 tgtcaaggcc aatttqttct accttaccta gtaggtaagt ctggaattgt agctgtggca 119461 ttttcagtaa tggtactcta ggttagcagt ccccaacctt tttggcacca gggaccagtt 119521 ttgtggaaga caatttttcc atgaagggct gggcagggga gtggtttcag gatgaaactg 119581 ttccacctca gatcatcagg cattagattc tcacaaggag tgcgcaagct agatccctca 119641 cacatgcagt tcacaatagg gtgtgcactc ccatgagaat ctaacaccgc tgctgatctg 119701 acaggagaca gagctcaggc agtaatactc atttgcctac cgctcacctc ctgccgtgca 119761 gctcagttcc taacaggcca cggaccagta ctggtccacg gcgcaggcat cagggacccc 119821 tgttgctagg tataagcatc tggctgctgc atgtcttctg tgtagctaca tctgtatgtg 119881 tatctgatga gatataaatt atttgattat aaattacttt cttcatatta gagttgtgaa 119941 tgagtatcac atataattat acataaacta ggaatatgct ttttaataat gtatataagt 120001 aagtttcctt aactatgact ttcatcttag cgtagtaaga gggtgctaag aaatatttgt 120061 gatgaaaata ggcattggta gagttgagac cactgggtga tgaaagagtg taaagatttt 120121 aaagccttca gatgctggtt caaggtgaga aatgtgattg ggagcaaatc aattaacttc 120181 ttgaagtctt atagggcagt tatgaatact taatgttaac atatgtaaag ctcttctgcc 120241 ctgtatacag taaatgctag ttagctatta tgatcactac taaaatgggg atgacataaa 120301 cctcataagg ttttaagtat tatgcaagat actatacaaa gtccagtaaa tatcacattc 120361 aattgaatcc atgatgtccg attattttag ctacttccaa gagagaaaaa aatgctgtca 120421 gttttactgt tcttatagag agcaaggcag atcccaattc ccaatgtggt aacgtgaaaa 120481 tttttgcatt tgaatcaaca aaacactttc tcctttcttt cctactattt aacaactggt 120541 aagtctatac tcccccaaat ctggaattct cctttcttat tctttttcct cctaccaaga 120601 ccgcaggatc ttttacttgg ctataagggg taaacctcaa gtagtacaag ttctctgtat 120661 tacttttata ctctgtcaca gattcccttt gtttcctcat ctccatgtga atttagttaa 120721 attctcagca ttctgatcct tactatacaa ggtaaatgaa tataaaaaca aaacgaaaca 120781 aaaacctctt cctatttaca taaggcccca acctaatatt tagtgatata tattaatgtg 120841 aacaaggaac taacgaagac tgggaagaaa ttcacagact tgagagaaga aatggcagga 120901 tttcctggga acaatttcat gtaacgtcaa aggtggtaaa aggtcaaata gaatgaagat 120961 ggagaatacc ggattttctt acaaaatgat ttcccaggag atctcatcaa atgcacgagg 121021 ataccttctc agtttcacct agtgagtaaa agactggtaa catagctcac ttacaatttg 121081 gataaacaaa actaaacaaa caacatcaaa atttcagaaa aaataatagc aaaacagaaa 121141 tcaaacactc aaatttttgg tccttctgtt tatttcattt tggatactca gtgaatgtta 121201 attaaccagg aaacttaaaa gttatttcaa ttatgaacct cttcaatcct tcatcaatta 121261 ttttgagtat tctggtctta aaaacatctc tttcttctac aaacttctga aagagatgaa 121321 cacctccacc tacaccaaaa taatgtgctt tgctggccaa aagtacacgt ccatttttac 121381 ttaacagtct aaggaaagtc tggtgcaaat tactataata atctgggttg taaatggttt 121441 ctgaggtgag aatgagatca tattttacaa aaagtttttc actacttagt acaagcttac 121501 aaaactcaga ccactcacca gaaaaaaatc ggcatttata tagttgtgtt acttttggtt 121561 tcctgcatct tttcacatct ggctcattta catcattttc ttcatcttcc aaagtggagt 121621 tagctactac attaggtaag gttacttcat caatcaccat actgttataa tcttgaaagt 121681 gaatttcttt ggaccctccc ttgaatgcag ttatacctag taaacctgat ccacaaccaa 121741 gatccaagac ttttttccca gcaaatttca ctttggcctt tgtgaaataa gccaggaggt 121801 caaaggtaca ttcccagatt tttaagcctc cctcataaac acctgtaatc agatcagagt 121861 gagaagaaaa gctttttgaa actatgtttt ctccagggaa gttctctttc aacaagatgg 121921 ttttcactac tgataactta acatgctgga aacctggtaa tgtttctatg actttatttt 121981 ctaacatctt ctttaaatct ttaggcatag catgctcttt ggcagctctc aaggagggct 122041 gttttccatg tggctccaag ttccttgaac tgctggctgc actgagtgga ctgtctgtgt 122101 cttgagaggg agctgcattt tccattgact tatgttccca caagtgatcc tgaggcaagt 122161 caaattgttc tgcagaacat tttctgtccc tctcttctcc tttttgactt tctgagactg 122221 acagctcttt tgaggaatcc agggtcaaag ctccatctct aatgggtgtt aattcatttt 122281 ccagatggtc ttctatagtg aaattaaact gaaaggtcat cctcttatta aatgcacaca 122341 atctttaaat tcagattctt caacttctgg atagaatttg atgatacaca caaatctgcc 122401 tcaattattc aattagtttt gttgggccca atttctcttt agcagcttat acatggtaac WO 00/09525 PCT/US99/17712 EPT-109 944 122461 aaatatttag agatatttcc aaatgacttt ttagacgtct ttggtcctct ttccaagcag 122521 ctctggaaag aaaaaaaaaa aaaaaagaaa gaaaatgatg attaaagcaa aatggcacat 122581 ttcactaaag tgtaatatta aacagccacc cccacccctc cctgtcccac catacagctg 122641 ctttttctta aaaagttgtg gggaagagag agagataaga gatttggaca ctcatacaca 122701 ccttaagggt tccaaagtgg gagaagaaaa tcaactataa aaacaaacag aagaacaaca 122761 gcaaccacca ccactaccac ctggacaaac ataaagtcca agatattcag acaggacagc 122821 ctagctactt gctgtctttc agctgtcttg atttgtgtcc aaccatattc accccctaag 122881 cttccagaat aacttcactt ctgtctttta cagaagaggt gcagtatttt attttggtaa 122941 gtcagcgtcc ctttaaaaac atgcataggt atggcctggt gtgtgtaaat tcatccaaga 123001 cttcactcca aacatttagt cgagaacagc agccctaagt gtatagaagt gggggtaatt 123061 tggcaataat tagtaaagac taattcggtg gcagagcaaa cgcaaactag ggcactgcag 123121 tagtttggag agacctgtag aaataagaag caactttatt gagaatcttc tatctactgc 123181 gctagacact ataccatctg cctcaatttt cacagttctg gcaagtggga tctttgttcc 123241 ctttatacaa gatttacaat ttgggggaga ggcgggtcac ccagtcccgc ggctaggaac 123301 gcgcctcttt cctctcccat cacgctgcaa ggcttggagt cacttccggc tgcaggtccc 123361 ggaacaaatc cgaccccaga agtggggact tctggccctc acctccccat ttgaatgtaa 123421 tgtttacagt gatccagacc tggggatgct tgcttcccga cgtgtcctgg gatcgcgctt 123481 ctgaaaaagc tcacctcaca acgcctcctc cggacctaaa tcgcgcacca gtgagtcgag 123541 tcctccaggg gctagagaag cccgactttc tttccggcct tgagggaccc gggctcacca 123601 agaaaccagc cgccctcctc tctatggttt tggagccggc ggagagcgcg caagggttgg 123661 cgggactgcg agtttccggt ctgggctttg gcgggtctgg tttgaagctc tcctgtttga 123721 cgaaagtatg tctcaggaag gtgcggtccc agctagcgcg gttccctgg aagaattaag 123781 tagctggcca gaggagctat gccgccggga actgccgtcc gtcctgcccc gactcctcat 123841 atccttcctt ggttgtcact tctacctaga gaagggtgtg ggcgggtcgc gaacctttct 123901 cttctgtccc ttcagaccca ccgccaggct gggttatatt accgcggcct gaaccccctc 123961 ttttctttgt cagtgagtgg gatgaaaagt gagggactgg aggggaagcg acaaccgtgg 124021 tagatttaag taaggctttg gccctggaaa gcctcgcgga cgtgttctga cccaaggttt 124081 tagcagtgga tgtggcgttt tcttccattc cttctttcag tttttCtgta ctcgttgctt 124141 gcaattaagt gtaaatactt ttgctagtgg ataatggggg aggcaaggac tgagacctgc 124201 ggtatgacga tagctctggc tcttaatagt ttgaggtaaa gcgagatact ctgagctttt 124261 gtctcccgta aaaagggtgg tgaatatgaa taagggcttt cttagcgtta taagaattaa 124321 agggcatagt tctgtggtgt gaaatcttta aaagatgttc agtaaataaa aatgattttc 124381 ctccttcccc tctcagacct ctttttcttc tttctttctt tttttttgac aagttctcac 124441 tcctctcacc caggctggag tctttctgaa agagttcttc cgcttgttgt tggctttcaa 124501 ctgttggatt tgaggcgctt agcgccttct tcgtccgggt gcagcacatt cttgattggt 124561 ctcatgcctt tgtggttgta aatgtgcctg gaatcctagc ctttcatggt aaaccatatg 124621 tatatgtatc tttttcacaa catttgagcc cagctttata caattacact caaaagaaaa 124681 aaagtaacct tcacttgaga gaatctcaat actgcacaaa tattgtgcag ctaaagccct 124741 atgtaatcac atagaagtca ttcacctagg cattagcaaa atctcagaag gtgccaaagc 124801 cccctttttt agtttttgtg taggtacaga actgccgtct tcaaggagtt tcaacttgaa 124861 aacaaatagc caccctcaaa acattcaaaa acacttaaac tgcgtgcata atgtgtgtga 124921 gacatggtgt taggctttgg gagaacagag acacggaacg tgattcctct tcttccccac 124981 aagcttatag agagacttca ttaagttgaa agtcaacatt cccacctagc tttgcacttc 125041 aaacgacata ttcaaaaaag cccaaacttc ctctagtttt cttcatctga gtaaatggtt 125101 tcacaaactq aaaccttgaa tcctctctgt ctcacacacc cgatcagtaa gttctattgt 125161 ttctgattcc aaactatgtc ttgaatcaat ccgtttatct ccatcctcat tgctaccact 125221 ctgattccaa acccttatca cctctcactt ggagtattaa tagtttcctt gtttctactc 125281 ataattcatt attccaaaaa agttaagagg ggaaaaacat agatctcgtc atttcccttt 125341 ttaaaccact ttaccttcaa ggttccaggt gatctaagcc ttgcccttct ctcataccta 125401 gttaattaac tacactctgt tcatgaatac attaggctca cctacctcaa gatctttttg 125461 ctcagcctga tttgttctct cagccttttg catatttcat gtttatgtct tggcccaaat 125521 gtcacttcct tagaggggct ttttcagagc cttcaatctt aggcagttcc cccaaacgca 125581 gtcttacact tgtatcacat tggcctgttc agttttctaa aaagcacatt accattaaaa 125641 gaaatgctct tgtttgcttt gtatattttc cacttctaca cattatgttg caaagttcat 125701 aaaggcagga tgttgatttt cttcacagcg ttaccctcag cacctagaac agtgcctgac 125761 acatagtaag cattcattaa agggctaaaa atatttcatg ttttaaaaat acttgggagt 125821 ctaattagac aatacttttt ttcagcttaa tggtagtatt ttagcttcac tattttaaca 125881 aatgaaaaat ttgcaataaa tctacaatgc cattaccccc caaaatcttt ttcatgtttt 125941 gcattttacg tattattttc caggccttac ctgcatgtct gcataatcat aactgactaa 126001 ttttggaaca gctggtaatt atttgagctt tactgaaatt ttttcatgag gccaattcta 126061 ccctactgaa ctcaaatttg agttaatgat gacctcattt tgattgctgc tgtaaaaaat 126121 aagatttcgg aagaggaatg aattcttgta ttactgtggt aggactatgg gttttttttt 126181 gtttgtttgt ttgttttgag acggagtctc accctgtcac ccaggctgga gtgcagtggt 126241 gcgatctcag ctcacagcag ccaggttcaa gtgattctcc ttcctcagcc tcccgagtag 126301 ctgagattac aggcacgtgc caccatgccc ggctaatttt ttgtatcttt agtagagatg 126361 gtttcaccat gttggccagg ctggtctcga actcctgacc tcgtgatccg cctgcctcag 126421 cctcccaaag tgctgggact acaggcgtga gccaccgtgc ccggccgggt tattcatttt 126481 tcttattaac attctttgat gattcttatg gtgttgttac agtaaaacat ttctaacaat 126541 tattctaaca attattcttg atggtgtata tgaagaattt attgtcgtgt atttgtaagc 126601 tgctatgtgc agaagaattt cagtcaaata aagttggtaa gataggtatg taagtaatat 126661 gaaaaaagat agaaggtgat gagtgactta ggtataaatt aagtacaata gaaatgttga 126721 ggaaagaaaa atttcttgta atagaaatcg gaagtacaaa ctgggcatgg tggtgtgcat 126781 ctctaatccc agctccttga gaggctggta tgggaggatc actttagccc aggagcttga 126841 ggctgcagtg aggtgtgatc atgtcaccgc actccatcc gggtgacagc aagaccgtct 126901 ctcttttttt ttttttttga gacggagtct cgcctatgct ggagtgcaat ggcgcgatct WO 00/09525 PCT/US99/17712 EPI-109 945 126961 tggctcactg caacctcrgc ctcccagttt caagtgattc tcctgcctca gcctcctgag 127021 cagctgggat tacaggtgtg cgccaccatg cccagctaat tattttgtat tttaagtaga 127081 gacgggttct caccatactg gccaggctgg tcttcaactc ctgacctctt gttcgcccat 127141 ctaggtctcc caaagtgctg ggattacagg tgtgagccac cccacttggc cccgagcgag 127201 accctctctc taaaaaaaaa taaataaata aatcataaac ctgtggatta ttgtagcatt 127261 gtttctcatc tgtcaaaaat atttcatgac tatgcatagt ttgaaaaggc aagtttgtcc 127321 ctgggcaatt ttcaaaatat ttctttaatg tgttttcaca atactgttta cctaataaat 127381 cttaagtttt taaaagcaaa attaagccag taatttgagt ccaattccaa tctcttatga 127441 gtcattgctt aaatttcaaa agggttttat ttttttttta ggtttgttct gagtaatgaa 127501 taccctatta ctatgatact agtatcttcc ttaattatcc tactcattgt ctcaacattc 127561 tgacagttgg attgagcata ttcgtaagta aaattgtttt aactgtatga tgtactttga 127621 tgttaaggtc cgagtcccca catacctcgg tagatgtgtt cttacagttt tgtattccct 127681 tgaaatgtaa ctgttctcta tgttacagcc tttataacct tcagttactt gaaatgaaca 127741 aattcattca aattccagca cttaaaagtt ttaaattaca ttttggataa ataccaaagt 127801 gttttgttga tgatgtatgt ataaacaaat tgtaaatatt aaacgttagt tgttacgatt 127861 agacctatat aaaacatgat atgcagteta ctgaatagct atcagcctct aacatgttta 127921 gtgtcattta gaaaatgctt tctaaattgc caaaagctga ttgtctaggt gataacaaat 127981 ttaccatttg gaggaagttg actttctcat tttcatgtct tcatcagtct tacttgatga 128041 gattcattct tctagtcaga agagagttta gactgctcag tttactcata ttttgagtta 128101 gcttttctat ttagagttca cttggttgtg gaatattcat ttataatttg aatctacgtt 128161 gtgtaatggg acctaatttt tttttccttt gtttttgttg gagtctcgtt ttgtcaccca 128221 ggttggagtg cagtggcgtg atctttgctc actgcaacct ccaccttcca ggttcaggtg 128281 attctcctgc ctcagtctcc caagtagctg ggattacagg catgcttcac cacgcctggc 128341 taatttttgt atttttagta gagatggggt ttcaccatgt tggccaggct ggtctcaaaa 128401 ctcctgagct caagtgatcc tcctgccttg gcctccataa gtgctgggat tacaggcgtg 128461 agccgctgag cctggcccca gagtttgttt tgttttgttt tcaagacaag atctcactct 128521 attgcccagg ctggagagca gtagtgcgat catagctcac tgcagcctga actcctgggt 128581 tcaagctatt ctcctgcctc catcttctaa agtgctgtga ttacaggtct gagccatgat 128641 gcttggcctg tgtttttgtt tgtttgtttt gggggacagg gtcttgcttt gtcaccaaaa 128701 ctggagtgta gtggtgcgaa catagctagc tcactgcagc ctccatctcc cacgctcaag 128761 caatcctctc acctcagcct tccaagtagc tgagaccgca ggtgcgtgct accatgcgtg 128821 gctaattttc tatttatata tttatttttt ggtagacatg aggtcttgtc atgtttccca 128881 ggtggtcttt aactcctggg ctcagacagt cctcccgcct cagccaccca aagtgttggg 128941 attacaggcg tgagccacca tgcgtggcat aatttttttt aagtaaatta tttttttatc 129001 ttgagtatag aagtgattca tgttcattgt ggaaaatatg aaacatatag aaaaacagaa 129061 aagattacaa aacatctaat ctgaaatggt taagattttg atgagaacag tctcatctca 129121 tttccgtata ttcctgccag cctatccatc attcttcgta catgtttatc tacattaaaa 129181 ttggtgttat attttggaaa ctttttgttt aactacattg tgaacatttt tcatgtttta 129241 aaatgtcatt ttaatgatgg cagatcctat tcaatagatg tacacacaco tatttaactg 129301 gtccacaatt gttggatatg taggtcgttt cctttctctc tttttttttt tttttggcta 129361 ctacttaata gtttctctgt atagaatgtg gtattttgaa agtgtatcaa gctttagatt 129421 ggtagtattc ttgcatttaa taaagggcag tggcctttgt tgactgacat gacaatattt 129481 ttataaaatt tgttatttgc tttacagaaa ttttgaaaat tattgtagaa atgtttttac 129541 ctcatatgaa ccacctgaca ttggaacaga ctttcttttc acaagtgtta ccaaaggtat 129601 aatactatta cctgaaaata catgttataa ggaatctagc ctcagtctta gatgatttat 129661 tattaattat ggctctcttt ttctaatata tcaaatatat tcaaaataaa aataaggagt 129721 aagtagatct catqtgagac tataatggtg ttagtgtgat cattaggcag ttaaaaactg 129781 ttacaggctg ggcacggtgg ctcatgcctg taatcccagc tctctgagag gctgaggtgg 129841 gcagatcatc tgaggtcagg agttcgagac cacccatggt caacatgatg aaacctcgtc 129901 tctactaaaa gtacaaaaaa ttagctggac atggtggcag gtgcctgtaa tcccagctac 129961 ttgggagact gagacaggag aattgcttga gcctgggagg cggaggttgc attgagtcaa 130021 gatcgtgcca ttgcactcca gcctgggcaa taagagcgat gctccgtctc aaaaaaaaaa 130081 aaaaaaaaaa aagaacttat attttcagat tgtgtggttc ctttactaac tgaatttaaa 130141 ttatttgtag tcaattttaa atgctcttgt attttaaagc cactgtactc cagcctgggt 130201 gacagagtga aacccttaat tcaaaaaaaa aaaaaaaaaa aagaaaagct ggaatattgg 130261 caaaatcaag taactaagag aaaacattaa attcacagaa tacattatta cattttagat 130321 atatatggta tatgttttct ctgaaaagca caagcatacc ttttttgttt taaatggagg 130381 gaactaaaga tactttggtg ccaaaatgaa acattatttg taattaatct cttattgaaa 130441 tgggtttcta actttagctt tgaatcgtaa tctttcaaat ttcttgtact catagtcact 130501 tgatgattct ctatctgaaa tatttcttag aatttgttct tgaccaccag aaaaagattc 130561 aactgttaca tagatgaaaa tggatgttga gtgttaacag gcctatggga aacagtattt 130621 tctttagcta cattgtattg ttgactgtgt tgctattctt ataatgttta ggtcatttaa 130681 attgttagaa agatccaagt attaagatct agggtggcta acttttcaca gacaaaaagc 130741 ttgtttgtaa ggtcatttac tataccctta attcaggaag gttagcttga attgggtcaa 130801 aaggaaactg gttagaaaat aagtgagtag tgaataggcg attcagtgca aattccttcc 130861 agaaaatacc cttgtaaatg actgtatgaa tgtggattct tcaagacagt caaatttatt 130921 gtgcgaaagt aatactttta ttttttgcat ctctaaaaca tgaactttga gtgatttttt 130981 aaaaaaattg atgctattaa atagattcaa accatagaaa tggaaaataa atttctgttt 131041 ggggcttttg gggggattat gttgtaaaaa taccttttct ctgtattttg tgcttaatta 131101 ggtacaattg ttaagctaga tgatagcctg tggatgttac tagtgcaaaa tcaaattatc 131161 gtattgtgtt ttctctgtaa agttttgtct tgtcttttct agtgatttct cttattcctg 131221 tttattactt gatttgtttt tacagactgt gaaattattc gatgacatga tgtatgaatt 131281 aaccagtcaa gccagaggac tgtcaagcca aaatttggaa atccagacca ctctaaggaa 131341 tattttacaa gtcaagtcaaa agtattagaa agcaggagag agagggagct taaagaatgt WO 00/09525 PCT/US99/17712 EPI-109 946 131401 caaaattttt atactgatac tgattagcta tgtattctta tgtaatggcc taatgttgga 131461 attaaattta tagaattaaa gacgtgaata tagaaacatg aattctgaat aataaactct 131521 tataagaaga gaagtcatca agctagctga ccctacctgt attttcaagg atatgtgtgg 131581 aacacctgcc atgtgttttg aagtttgtgt tagtattcta aatggctaga cagttgttcc 131641 agtatttgta gttctgatag actaaagttc tgtgaaaaga ggaagagact gtgttttgtt 131701 cattgctgta tttgtagcac ccagcatgct gactaatacc ttttcagtgc acaaaaaata 131761 tattctaagt gaaatttcct tccttattca cagacaatgg tgcagctctt aggagctctc 131821 acaggatgtg ttcagcatat ctgtgccaca caggaatcca tcattttgga aaatattcag 131881 agtctcccct cctcagtcct tcatataatt aaaagcacat ttgtgcattg taaggtgagt 131941 aaaggtctaa ttatactttg aatggtatat aatcaatgtg cataggggct gagtaaaata 132001 atgtttgtat aagattttac attttagtct atattattga aataaacttt tccatagaat 132061 aaagaacatg taagtaaata attgttgcaa aaaaagtggt tttaaggaag tcattaaaag 132121 tggctttttg gggtttttta gttttatctt atttcccctc tataaagaaa gaagttttaa 132181 gaatttgtgt tgagacagac acagggatcc tgaaatagtt atgtcatgtt gcattgacca 132241 atattcaatt accattatga ttagatgtca gaacttcctt ttataaagga aagttaatcc 132301 ttatttagtc catctctaca tgccagaggt agccttgagg cacaaaagct tgcctagaat 132361 ttatgggtca cagacagttt taatattgct atttgttggg cgaatgaaaa tcactagtta 132421 attaatacct ctctttgctg ataggatgct aaaaatgtca cgcacctggc ctaatgttac 132481 ccttttttag ttctgtattt gcaagatcat ggaagtcaga aataatattt tatacatgct 132541 tgcatctctt gaagcacact atatttaatg gatgttcact aaacaatgaa tgaatatgtg 132601 attcagtaaa tttatgatct ctaatagtat gaattaaagt aaatttggct cttgagcttt 132661 gatttgtttt ttctctcatt tttatttatc cgtaatcaga atagtgaatc tgtgtattct 132721 gggtgtttac acctagtttc agaccttctc caggctcttt tcaaggaggc ctattctctt 132781 caaaagcagt taatggaact gctggacatg gtttgcatgg accctttagt agatgacaat 132841 gatgatattt tgaatatggt aataggtgag tgaagaaaac tttctgctta gtatatggtg 132901 actataaatc atgtatcaat taaaattgtc tctaatgatt catgttattt tcttactaat 132961 tatgcattaa aattgattta aatcttacca aataaatttt taatcttgaa atttggaatt 133021 tgtaaaattt attttgggta ccttaaccta gatttgcgta tttagttact gtaatttctc 133081 cacaatgatt aacttatata actttataat ctctgaggtt gtccatattc agagacaata 133141 actttcacat ttttttaacc ataactgata ttgagatgca gtttatattt ccttccagaa 133201 tacatataaa tacgtgcata tgtgtatgta aatatgtcta ttctcatata catattataa 133261 tgaaataact cattttacat gtgatgcact ttatactagt ttatttttat tttattttat 133321 ttttttgaga cagagtctca ctgtgtagcc caggctggag tgcagtggca caatctcggc 133381 tcactgcaac ctcgcctccc ggactcaagc gattctcctg cctcagcctc atgagtagct 133441 gggattatag gcgtccgcca ccacacctgg ctaatttttg tatttttagt agagacaggg 133501 tttcaccgtg ttggccaggc tggtcttgaa ctcctgacct caggtaatcc acctgcctca 133561 gcctcccaaa gtgctgggat tacaggcatg agccaccgtg cccagccaat actagtttat 133621 ttttaaagaa ttgctggtcg taacacactt cattgatttt atcactcatt aatggattat 133681 gaacaagagt ttgaaaaaca atataaaggc aaagtttgca ttcaaaactt tggtataaag 133741 agagtaagtt ggttttgtgc agtgtatcag gcacctgttg ctctgcaaca caccacctca 133801 aaatctattt attcactatt tatttattca tgattctgtg agtctgcagt ttagggtggg 133861 atgtcctgag acaactttct ctgatccacc tggggcacta gctcacccat gtgacttcag 133921 tgacttcatt cacatctggc tgttggcaga ggcagaagta cttgagaaag ccatgtgcat 133981 catccagcag gttcacccta tctcagatac ctgatgccag tggtttcagg gtttctaaga 134041 gtagcaaaag tgtgagcagg tcgctgtgtg ctagcacttt tcaagtttct gcttgcctta 134101 attttattat tgtcccccgg gccacagcag gtcatagcgt ttagcccaga gtcattgtag 134161 aaaagtgtgg attcacaaag ggcagtcatt gtggccattt ttataaataa tctaccacag 134221 actgagtaaa agccttgcat gaataccatg gatattaatt tgaattcttc ctttttagat 134281 tttctttcct tagcaatttg ttttgtcatt ttggattaga attatatctg tagaatattt 134341 cagttataat agggtacaac ttttattcca ctgaacatct ttagttttat ttaggtcatc 134401 tggtaggtat aaacttcaga agttaatatt caatatttat aaaaaccatt aacaagtgtg 134461 acacttaaat agtttaaata attcttttga cacaactgtt tccaagttgt gttacgtatt 134521 ttaattcaat caaatgttga aattgttcag tagatagttt taattatagg agaaactcac 134581 ccccatgaca tttggatgtc ttaaaagttc tgttatcttt ctttgcagtt attcattctt 134641 tattggatat ctgctctgtt atttccagta tggaccatgc atttcatgcc aatacttgga 134701 agtttataat taagtaagtt tgtttgttat tttttacttt ttagaaaatg ttttccatat 134761 tccccaatct taattattca tgattcttta gattgcattt aaaacatttt gtgtgaattt 134821 aatgttcact gacactgctg tctgataatc cagatattct acatgtagct ctcaagccaa 134881 attggacttc tttaccctgt ggcctctaaa attaaaaaaa atgttcttcc tagttagcta 134941 gtacttcaga aataatgggc catgggccag actagaactt aaccactttt cttctgctac 135001 tgttgtttaa ccagctatca agtatcctat ttctaggatt agataaattg ataactataa 135061 ttaaaactga atataatctt ttcattaggt acttttaagt tgttcacact taattccatt 135121 tgtacagtaa ttttaacttt ctgaaactga agcattttaa agggtcacca gggatagtgc 135181 ctgtagcatt catcagattc ttaggggtga gaggagatgt ggttgagatg taaaaatggt 135241 taagaatatc tactttatac acatacataa aacattaaag gtcagtgtat tttcaggtct 135301 taggtacttt tcttgtacta ccaggacatt aagttgccat tcagtggtta agagtgttgc 135361 ctgggagctg tatcacatgt gcttaaatcc attcttgaaa tcatttactc cttctgagcc 135421 cttgggctat ttggttaatt tctctgaacg ttagtttgct catctgaaaa tggaaataat 135481 aatagcaact tcttgacagg gttatagtga gaattgagtt catcactgtg aaatgcttag 135541 aaatgtgcat gacacatagt taatactcaa ggaattagcc acatcactat catcatcact 135601 gattatcttc cactcttacc ctcttccagt tcattttctg cccagcagaa tgatctttta 135661 aaaagtaaat cagatcatgt tactctattg cttgaagtct atcccatttg attaagaata 135721 acaacctaat cctctgtgga tgctgcctcc ttcaccagcc tgtctcatgc tgctctccct 135781 actcttagtt cctcaaacat accaaactct cctgtcccag agtcttttcg tggtttttcc 135841 atctgcctag gatgcttctc tctcctattt tgtgtacctt gctaactcct gcttactgtc WO 00/09525 PCT/US99/17712 EPI-109 947 135901 tttcagttct cagcttaaga gttatatctt catgataaca ttctttgata tccttaccct 135961 aagattaagt tagattgata tccttaccct aagaataagt taqattaggt ctctctattg 136021 tagcacctta gactctgtca tttgacaaat cacagcccta attaattatt cttaaaatta 136081 tttaacattc tctctcatgc tagaccacaa gtttcatgca ggtaaggcgg agattgtgtc 136141 catttgtttg acccctttgt ctccagggcc tggtagaatg cctcatacat agtaagaatt 136201 caattaatat tttacacaga gaaaaaatta gcaacttatt taaacaaata taactgcttc 136261 agaggtaaac tgggcacatc ttagttatat tatgtgatat atgatgcttt ttgattgttt 136321 ttttaaatgt tctacaaggt agatattgtt agaggtccta agttacttga tgtgttactt 136381 gtggtgattg tattcttttc tttttattca tttaggcaga gccttaagca ccagtccata 136441 ataaaaagcc agttgaaaca caaagatata attactagct tgtgtgaaga cattcttttc 136501 tccttccatt cttgtttaca gttagctgag cagatgacac agtcagatgc acaggtaaaa 136561 tttgggctaa tagcatttta aacagcaact cttattttct ttggcagtta gtaaatctca 136621 tttgaatgtc tgggtcagtc tatttaagag gattttaatt tatttcattt gggtgttttt 136681 ttttgatctg tgggattatt tatatcccat aattactttt cacccagagc attgtattag 136741 attcctaact gctgtcattg cctctggggt ctgcctggct ccctctttgc ttggtaactg 136801 gttggtcaca gcattcttct cagaatcctt tcattctttt ctgcatgaga acaaaaattc 136861 ttttgttcat atttgtataa gatctgatat agctgcaatc aatcttgcat tttttcttca 136921 ccaacgcatt gcgaccttta gggatacaag tatgtttgtg catgtatatg tatgtatcag 136981 tcttttaaat ttgatatagt catacatttg tttttatttt gaaaagttag agtgttgaat 137041 tggtatccca tttatgaaac attatattct aaaaatttgt agtacgatta ttgggaatta 137101 taactcattt tcctgtaaca ctgttataca tagtaccttt tgctttcaga ctagccctca 137161 attttattta actatagtag tcctaaatta taagattaat agtactcagg acctaacagt 137221 tatatgtcat ttgttttttt tttttttgag atggcgtctc actctgtcac ccaagctgga 137281 gtgcagtggt atgaccttgg ctcactgcag cctctgcctc acgggttcaa gggatcgttc 137341 tgccttagcc tcctgagtag ctgggattat aggcgcctgc caccacgcct ggctaatttt 137401 tttagtagag acggggtttc gccatgttgg ccaggctggt ctcgaactcc tgacctcagg 137461 tggtccaccc gccttggcct cccaaagtgc tgggattaca ggtgtgagcc accgcgccca 137521 gcctatatgt aataatttta atgggaccat gaattgaata tttcttcctt gaatagcaat 137581 gacatagccc cttctattgt acatctgcaa gctgatacag ggaattcctt tgtacctgcg 137641 ctcttccctg ccagtcagct atgggggtga aagtgtaggg gttcatccaa gtcctaaaac 137701 tggtagcaac tcctagggca gggctgatct ggaaggacag accctagggg agggtggaac 137761 tttaaaaaga agttctgaag gtagtaagaa ggaaatgagg agtagtgtta ggaaggggct 137821 aacttttttc ttcttgcttc tcttctttat ctcacctgcc cctccccttg tatcccttct 137881 tcctttttcc ctttcctttt ttgtcctcac ttcattcgtg catcctttct gattcctctt 137941 accttgctaa aaggagaagt ttgtttgggt atcctatatc aatggcagga aggttgtttt 138001 cttctttacc tttatcctat agattcatat tctcaacacc aacctcctcc tttttcagtt 138061 tccttcttgc ttctcttgac accacagagt ttgcagctag tacttggaga ggaaaattaa 138121 acagagatac ttggaccaag agtaagatga agaaagtcta aacaacagta tagtctatag 138181 tggcaagaga gagtatgggg gctgcttagc cagggtggct gtacataaag tatatcttca 138241 gtttatataa actgcttata gatggaaatc agaaaattta aattctctta actgtccaag 138301 aaaattctca ttttttcaaa tttgggactg ataaatgtga ccagttctgc ttactgtcca 138361 ttgcctgaaa tggagctttg aggtggactg tataatttct tcaatcttaa ctccaaattc 138421 tgatcagcga cgccctctgc tgttcactat taatatttat ttaccaatca aagtaaagta 138481 ttgaagtttt cctggcagtt ttcactttgt gttttagtcc atttaggctg ctataacaaa 138541 atcccttaaa ctgggtaagg gattataaat attagaaatt tatctctcac agttctggaa 138601 gctgggaagc ccaatatcaa ggcaccagta gatttggtgt ctaacgaggg tgtgccgtct 138661 gcttcaaaaa tggccccttg ttgctgcatc ctcacttagt gcaaggggca agacagctcc 138721 cttcaacctc ttttataagg gcacttatgt cattcatgag ggcagagccc tcatgactta 138781 atcacttccc caaaggcccc acctcttaat agtatcacat tgggtgttag gtgtctggga 138841 ggacaccaat cttcaagcca tatcatctca cttggaaaaa agtcaaaata aaaccagtag 138901 atttaattaa tattacacta tttatagaag catgtgatgt atcattcctt gtattaattt 138961 cctggggttg ccgtaacaag ttaccacaaa ctaggtggct taaaacaata gaattttatt 139021 ctctcacatt tctagaggca gaagttcaca gtgtgtcaat agggccatgt tctctggaag 139081 gctttagggg agaatatatt tcatatcttt ctcttagctt ctcggtgtca ctggcaatcc 139141 ttagcttact ttggctttct gtgtcttcac atcatctttt tataagaaca ccagtgatag 139201 tgattaaggg cataccttac tttaatatga cctcatctta actaattatg tcttcaataa 139261 ccctatttcc aaataaggcc acattctgaa gtattgggag ttagaactta aagctttttg 139321 ggagggacac agttcaaccc ataacaaccc ctaaaatcga tatttattct caattaagtc 139381 ttgaaattgg tttcaaaaag agaatattct attagagttt ttaatgtata gttttaacat 139441 atagttcttt agcccccaat tttttttttt tttttttttt tttttttttt tttttgagac 139501 ggagtctcgc tctgtcgccc aggccggact gcggactgca gtggcgcaat ctcggctcac 139561 tgcaagctcc gcttcccggg ttcacgccat tcccctgcct cagcctcccg agtagctggg 139621 actacaggcg cctgccaccg cgcccggcta atttttttgt atttttagta gagacggggt 139681 ttcaccttgt tagccaggat ggtctcgatc tcctgacctc atgatccacc cgcctcggcc 139741 tcccaaagtg ctgggattac aggcgtgagc caccgcgccc ggcctgcccc caattattta 139801 gtttttctat aaacagggaa atttatttgt gtggccctta gaactaattt aatttccact 139861 ctaattccta cttatgttta tataatgctt ttagaaattt gtattattca gaaaataaac 139921 atatactatt gtatctgttg cctacactta gattttattg cctgctatat ttaaatttta 139981 ttagtatttt aattgtttta ttaaagaaag aatgtgcctg taatctcagc acttttgaga 140041 ggccaaggca gaaggattgc ttgagcccag gagtttgaga ccagactgag caacacaggg 140101 agacccccat ctctacaaaa aataaaaaaa ttctccaggc ctcatggcac atacctgtag 140161 ttctagttac ttgggagact ggggtgggag gatgcattga gcccaggaga ttgaggctgc 140221 agtgagccat gatcaggcca ctgtactcca gcttggacaa cagagtgaga gcttgtctag 140281 atagatagat agatagataa tctaaataga taatagacag attatctaaa tagataatag 140341 acagattatc taaatagata atagacagat tatctaaata gataatagac agattatcta WO 00/09525 PCT/US99/17712 EPI-109 948 140401 aatagataat agacagatta tctaaataga taatagacag attatctatc taaatagata 140461 atagattatc taaatagata atagatagat agattagata gatagataga tagatagagc 140521 ttggacaaca gagtgagagc ctgtctagat agatagaaac aaagaaagaa agaaagaatg 140581 gtgctcatat tttaaagcat tgaaaaatgg tcttccttgc ttatattacc cacaccttct 140641 ttgttggcat taagatgcaa actttgtttt aaacagttga gtaaatcaaa gatgggactg 140701 ttaagttatt tgtgttattt acctgctttt tgaaaatgta aaaataaaac tctaggttta 140761 attagtagta tgctatttag taatgaagta aagctagagg cttcgaacaa atcttgtgta 140821 atttcctctt gaatgagaga gaaaatttaa agtaagcaaa caaataagtt gtgtgtcacc 140881 actcattcag tcatttaaca agtatttcca gagtacttat tctgtgccag gaaatgttgt 140941 aggtgccctc aacaacttag agtctagcct gagacacaag taagtaggta attattatag 141001 aatggtatga tctttggagg actgggtatt ggctggctca tgggagtaca agataggtac 141061 ccagtgatga agtcaggaaa ggtttcttat ggtgatatga tgacgtctat gctgattata 141121 aggtcagtgt agaataaact ttgtgctttt aaatttgcat agcactgtat tagagagttc 141181 atcttcaaaa taatcgaaaa ggctgagtgt ggtgaccat ggctgtaatc ccagcacttt 141241 gggaggccga ggtgggcaga ttgcttgagc taggagttcg agaccaggct ggccaacatg 141301 gtgaaacccc gtctctacta aaaatacaaa aattagccag gagtgatggt gcgcacctgt 141361 aatgccagct acttgggagg ctgaggcagg aggatcactt gaacccagga ggtggaggtt 141421 gaagtaagcc gaggtcatgc cactgcactc cagcctgggc aaagagtga gactccatct 141481 caaaaaaaaa aaaaatgatc aaagaaaggt gaattttcat ctaccctatt tctgctgagg 141541 aaaatggact attttcaaat atttttaata agggtcaaaa tgagggatc (2) INFORMATION FOR SEQ ID NO:2695: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: _base pairs (B) TYPE: nucleic acid (C) STRA NDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2695 1 cctctctcgg ctagacgagc ttccccaact ggtaaccctt ccacacccca atcttcatgg 61 accagagatc ttggatgttc cttccacagt tcaaaagacc cctttcgtca cccaccctgg 121 gtatgacact ggaaatggta ttcagcttcc tggcacttct ggtcagcaac ccagtgttgg 181 gcaacaaatg atctttgagg aacatggttt taggcggacc acaccgccca caacggccac 241 ccccataagg cataggccaa gaccataccc gccgaatgta ggtgaggaaa tccaaattgg 301 tcacattccc agggaagatg tagactatca cctgtaccca cacggtccgg gactcaatcc 361 aaatgcctct acaggacaag aagctctctc tcagacaacc atctcatggg ccccattcca 421 ggacacttct gagtacatca tttcatgtca tcctgttggc actgatgaag aacccttaca 481 ggtaattaat tgttctcttc acttctcatg gggcagcaca gaaaggaata agttaggtaa 541 ctgaagtgac cagccctcga ataaaaagtg gcttcatggc cgggtgtgat ggctcacgcc 601 tgtaatccca gcactttggg aggccgaggc aggtggatca tttgaggtta ggagttcaag 661 accagcctgg ccaacatggt gaaacctcgt ctcttgaaaa aaaaaaaaaa aaagtggctc 721 caccttttag aacctcttag aagatggcac atttaagccc tgcttttttt tttttttaaa 781 tcccaatatg gctctacttt ggaggacata ccagagagtc actagccttt tatttccata 841 gagaaaatga aactatttct cttattctca cacatttgag gttccttttt gagtaagata 901 gatggttcta gaaaagaaag aaagatattc tacctgaatt tccatttgtg tgcagaagtc 961 taaaacacta cctttacgat ttgtccttga agaaccccac tatctacaac atatctaaag 1021 aaaaaaaaaa acagcgaagc tgtgcatagc ag (2) INFORMATION FOR SEQ ID NO:2696: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2696 1 atcaaacaga aatgactatt gaaggcttgc agcccacagt ggagtatgtg gttagtgtct 61 atgctcagaa tccaagcgga gagagtcagc ctctggttca gactgcagta accagtacgt 121 aaccactgct tggtttccat tttcaaagtc aaattttgtt cttgggtgtc tgaatgccca 181 cgacatgtct tttgcaatta cacataggga aagtgaactt gttggttagt ttatgtcttg 241 agctgagccc tttacgaaca tcttttttcc ttctcagtgc caagcgagga atttacagag 301 aaagaagttg tgaaaccacc atagttagtt gctgtgcttt gaatttcttt ttgctcaaat 361 ggcctcagcg aaatcttatt tgcctatagc aaatctacaa aaaattttcc tagaccgtct 421 tttctacaac tggatggtaa agttgattga agtgtgcctc atgtagcttt atgtttgggg 481 catttgaagg gctatggctg gaccagagtg taatataaat gcttaataga gaggggaaaa 541 gaagagtgta agaaccatta tagggctggg ctcacgcctg taatcccagc attttgggag 601 gctgaggcgg atcacgaggt caggagttcg agaccagcct gaccaacatg gtgaaacccc 661 atctctacta aaaatacaaa aattagccag tcgcggtggc acgtgcctgt aatcccagct 721 actcacggag gctgaggcag aagaatcact tggacccagg aggcagaagt tgcagtgagc 781 caagatcatg cctctgcacc ccagcctagg tgatagagtg agactccatc tcaaaaaaaa 841 acaaaacaaa acaattataa caatttgaat ctgaaccata tgcaaatcag ctttaccact 901 tccaaggtat aagaaaatcc aggtctatga gactaacatc acattgtaaa aatcaaatcg 961 tggtagaata cctttaaatt aatataaata catccccatt gtggggacat tttgcagggt WO 00/09525 PCT/US99/17712 EPI-109 949 1021 atctgcttat ctcacataca ccatgtttta ataagtgatg caacattgca tattttctaa 1081 accaagaaaa attaagcaag tgtttaagtg atttttcctt tgatagtggg ttaattggac 1141 ttcatcaaag aaaatggtat ctgcaaaact gctttgcatg ttataaaaat gcttatttca 1201 caacttgctt tcacataacc tcttaccatt aatttgccta acagacattg atcgccctaa 1261 aggactggca ttcactgatg tggatgtcga ttccatcaaa attgcttggg aaagcccaca 1321 ggggcaagtt tccaggtaca gggtgaccta ctcgagccct gaggatggaa tccatgagct 1381 attccclgca cctgatggtg aagaagacac tgcagagctg caaggcctca gaccgggttc 1441 tgagtacaca gtcagtgtgg ttgccttgca cgatgatatg gagagccagc ccctgattgg 1501 aacccagtcc acaggtatat ggttaattgc acacaggtgc catgggagca gcggctttat 1561 gcctactgaa tgaattatgc ttcactgggc tattgattcc cgtgtaaggg tgaaaaagaa 1621 ttattaggaa agatcctctt taaagaggaa tggtaagaaa caataaaact taggtgatat 1681 ttaaggaaac aagtctgatt aaaagaaatt ttggagtatc ctggcttata cacaagacca 1741 taaagcaaga catttgaaga ggatactaaa gttgtggatt atttcctaag ctctgactcc 1801 ctgtgattac cctcactatg tataaagaaa agaagtttgg cattacagag cttacttata 1861 aaaaggaacc caaactcggg catttcatag cagcatgatt ctgagcacac gtgggtaaga 1921 cctttcttct ctggttagat atcatatgct ggtgtataat tagcttaaat gattgtgatt 1981 tagacaccta ggaaataatc aatagggcaa ttgctttcca taatacttta tcttcttgtg 2041 ctttatttct gaagcagagt agaatgctaa agatgtatcc tagtgacagc ataaacccta 2101 gaggtgacag tctgtattat tgcttttcgc ttctcttttc tgcttctgtt gggagccagt 2161 tttcttctta cgccgcatta cagagagaac gtcaaattta gcaagccata tctgccatag 2221 gtccaaataa agagacaata aaaattattc tctctttttt ggatggaata ctgcgtgaaa 2281 tggttatcca tacaaagata ctttatgtag aatagaaaaa ggaggccggg tgcagtggct 2341 cacacatgta atcctagtgc tttgggaggc taagccggga gcactgattg aggccaggag 2401 ttcatgatca gcctgggcaa tgaagtgaga ccccgtctct acaaaaaaat atgaaaaaat 2461 tagcgaggtg tggtgacaca tgcctgtagt cccagctact caagaggctg aggtagagga 2521 tcacttgagc ctacgagttc aaggctgcag tgagctatga taactccact gcactgctgc 2581 ctggatgaca cagagagacc gtttctaaat taattaatta acaattttaa gaaagaaaaa 2641 gggccattgc ttatttttcc atacaaaagt aaaataaatc ataatggcca ataagccaat 2701 gtaacttttt tttttaaggg aaagcaaaac ttgtaaaacc taaaatctct tagagttttg 2761 gcatttaccc aaatgttttc agtgattctg agaattggtg gatataaaac acatttctca 2821 gcaaacactt tcttcatttt gcatccctta ctgtactttc ttgtactgaa tctttgcttg 2881 accagggaac ccacctagcc caacaagaac aatccattct acttcttgga actacgttta 2941 ttttcctttt cccccatttc ctataagata acctctaacc aatgacaatc tcgacagcta 3001 ttcctgcacc aactgacctg aagttcactc aggtcacacc cacaagcctg agcgcccagt 3061 ggacaccacc caatgttcag ctcactggat atcgagtgcg ggtgaccccc aaggagaaga 3121 ccggaccaat gaaagaagtc aaccttgctc ctgacagctc atccgtggtt gtatcaggac 3181 ttatc (2) INFORMATION FOR SEQ ID NO:2697: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: _base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2697 1 ctgcactttt gataacctga gtcccggcct ggagtacaat gtcagtgttt acactgtcaa 61 ggatgacaag gaaagtgtcc ctatctctga taccatcatc ccaggtaata gaaaataagc 121 tgctatcctg agagtgacat tccaataaga gtggggatta gcatcttaat ccccagatgc 181 ttaagggtgt caactatatt tgggatttaa ttccgatctc ccagctgcac tttccaaaac 241 caagaagtca aagcagcgat ttggacaaaa tgcttgctgt taacactgct ttactgtctg 301 tgcttcactg ggatgctgtg tgttgcagcg agtatgtaat ggagtggcag ccatggcttt 361 aactctgtat tgtctgctca catggaagta tgactaaaac actgtcacgt gtctgtactc 421 agtactgata ggctcaaagt aatatggtaa atgcatccca tcagtacatt tctgcccgat 481 tttacaatcc atatcaattt ccaacagctg cctatttcat cttgcagttt caaatccttc 541 tttttgaaaa ttggatttta aaaaaaagtt aagtaaaagt cacaccttca gggttgttct 601 ttcttgtggc cttgaaagac aacattgcaa aggcctgtcc taaggatagg cttgtttgtc 661 cattgggtta taacataatg aaagcattgg acagatcgtg tccccctttg gactcttcag 721 tagaatgctt ttactaacgc taattacatg ttttgattat gaatgaacct aaaatagtgg 781 caatggcctt aacctaggcc tgtctttcct cagcctgaat gtgcttttga atggcacatt 841 tcacaccata cattcataat gcattagcgt tatggccatg atgttgtcat gagttttgta 901 tgggagaaaa aaaatcaatt tatcacccat ttattatttt ttccggttgt tcatgcaagc 961 ttattttcta ctaaaacagt tttggaatta ttaaaagcat tgctgatact tacttcagat 1021 attatgtcta ggctctaaga atggtttcga catcctaaac agccatatga tttttaggaa 1081 tctgaacagt tcaaattgta ccctttaagg atgttttcaa aatgtaaaaa atatatatat 1141 atatatatat tccctaaaag aatattcctg tttattcttc tagggaagca aactgttcat 1201 gatgcttagg aagtcttttc agagaattta aaacagattg catattacca tcattgcttt 1261 aacattccac caatttact actagtaacc tgatatacac tgctttattt tttcctcttt 1321 ttttccctctc attttccttt tgcctccccc tccctttgct ttgtaactca atagaggtgc 1381 cccaactcac tgacctaagc tttgtgata taaccgattc aagcatcggc ctgaggtgga WO 00/09525 PCTIUS99/17712 EPI-109 950 1441 ccccgctaaa ctcttccacc attattgggt accgcatcac agtagttacg gcaggagaag 1501 gtatccctat ttttgaagat tttgtggact cctcagtagg atactacaca gtcacagggc 1561 tggagccggg cattgactat gatatcagcg ttatcactct cattaatggc ggcgagagtg 1621 cccctactac actgacacaa caaacgggtg aattttgaaa acttctgcgt ttgagacata 1681 gatggtgttg catgctgcca ccagttactc cggttaaata tggatgtttc atgggggaag 1741 tcagcaattg gccaaagatt cagataggtg gaattggggg gataaggaat caaatgcatc 1801 tgctaaactg attggagaaa aacacatgca atatcttcag tacactctca tttaaaccac 1861 aagtagatat aaagcctaga gaaatacaga tgtctgctct gttaaatata aaatagcaaa 1921 tgttcattca atttgaagac ctagaatttt tcttcttaaa taccaaacac gaataccaaa 1981 ttgcgtaagt accaattgat aagaatatat caccaaaatg taccatcatg ctcttccttc 2041 taccctttga taaactctac catgctcctt ctttgtagct aaaaacccat caaaatttag 2101 ggtagagtgg atgggcattg ttttgaggta ggagaaaagt aaacttggga ccattctagg 2161 ttttgttgct gtcactaggt aaagaaacac ctctttaacc acagtctggg gacaagcatg 2221 caacatttta aaggttctct gctgtgcatg ggaaaagaaa catgctgaga accaatttgc 2281 atgaacatgt tcacttgtaa gtagaattca ctgaatggaa ctgtagctct agatatctca 2341 catgggggga agtttaggac cctcttgtct ttttgtctgt gtgcatgtat ttctttgtaa 2401 agtactgcta tgtttctctt tgctgtgtgg caacttaagc ctcttcggcc tgggataaaa 2461 taatctgcag tggtattaat aatgtacata aagtcaacat atttgaaagt agattaaaat 2521 cttttttaaa tatatcaatg atggcaaaaa ggttaaaggg ggcctaacag tactgtgtgt 2581 agtgttttat ttttaacagt agtacactat aacttaaaat agacttagat tagactgttt 2641 gcatgattat gattctgttt cctttatgca tgaaatattg attttacctt tccagctact 2701 tcgttagctt taattttaaa atacattaac tgagtcttcc ttcttgttcg aaaccagctg 2761 ttcctcctcc cactgacctg cgattcacca acattggtcc agacaccatg cgtgtcacct 2821 ggg (2) INFORMATION FOR SEQ ID NO:2698: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2698 1 gaagagcaag aggcaggctc agcaaatggt tcagccccag tccccggtgg ctgtcagtca 61 aagcaagccc ggttgttatg acaatggaaa acactatcag ataaatcaac agtgggagcg 121 gacctaccta ggtaatgtgt tggtttgtac ttgttatgga ggaagccgag gttttaactg 181 cgaaagtaaa cctgaagctg aagagacttg ctttgacaag tacactggga acacttaccg 241 agtgggtgac acttatgagc gtcctaaaga ctccatgatc tgggactgta cctgcatcgg 301 ggctgggcga gggagaataa gctgtaccat cgcaaaccgc tgccatgaag ggggtcagtc 361 ctacaagatt ggtgacacct ggaggagacc acatgagact ggtggttaca tgttagagtg 421 tgtgtgtctt ggtaatggaa aaggagaatg gacctgcaag cccatagctg agaagtgttt 481 tgatcatgct gctgggactt cctatgtggt cggagaaacg tgggagaagc cctaccaagg 541 ctggatgatg gtagattgta cttgcctggg agaaggcagc ggacgcatca cttgcacttc 601 tagaaataga tgcaacgatc aggacacaag gacatcctat agaattggag acacctggag 661 caagaaggat aatcgaggaa acctgctcca gtgcatctgc acaggcaacg gccgaggaga 721 gtggaagtgt gagaggcaca cctctgtgca gaccacatcg agcggatctg gccccttcac 781 cgatgttcgt gcagctgttt accaaccgca gcctcacccc cagcctcctc cctatggcca 841 ctgtgtcaca gacagtggtg tggtctactc tgtggggatg cagtggttga agacacaagg 901 aaataagcaa atgctttgca cgtgcctggg caacggagtc agctgccaag agacagctgt 961 aacccagact tacggtggca acttaaatgg agagccatgt gtcttaccat tcacctacaa 1021 tggcaggacg ttctactcct gcaccacgga agggcgacag gacggacatc tttggtgcag 1081 cacaacttcg aattatgagc aggaccagaa atactctttc tgcacagacc acactgtttt 1141 ggttcagact caaggaggaa attccaatgg tgccttgtgc cacttcccct tcctatacaa 1201 caaccacaat tacactgatt gcacttctga gggcagaaga gacaacatga agtggtgtgg 1261 gaccacacag aactatgatg ccgaccagaa gtttgggttc tgccccatgg ctgcccacga 1321 ggaaatctgc acaaccaatg aaggggtcat gtaccgcatt ggagatcagt gggataagca 1381 gcatgacatg ggtcacatga tgaggtgcac gtgtgttggg aatggtcgtg gggaatggac 1441 atgcattgcc tactcgcaac ttcgagatca gtgcattgtt gatgacatca cttacaatgt 1501 gaacgacaca ttccacaagc gtcatgaaga ggggcacatg ctgaactgta catgcttcgg 1561 tcagggtcgg ggcaggtgga agtgtgatcc cgtcgaccaa tgccaggatt cagagactgg 1621 gacgttttat caaattggag attcatggga gaagtatgtg catggtgtca gataccagtg 1681 ctactgctat ggccgtggca ttggggagtg gcattgccaa cctttacaga cctatccaag 1741 ctcaagtggt cctgtcgaag tatttatcac tgagactccg agtcagccca actcccaccc 1801 cagccagtgg aatgcaccac agccatctca catttccaag tacattctca ggtggagacc 1861 taaaaattct gtaggccgtt ggaaggaagc taccatacca ggccacttaa actcctacac 1921 catcaaaggc ctgaagcctg gtgtggtata cgagggccag ctcatcagca tccagcagta 1981 cggccaccaa gaagtgactc gctttgactt caccaccacc agcaccagca cacctgtgac 2041 cagcaacacc gtgacaggag agacgactcc cttttctcct cttgtggcca cttctgaatc 2101 tgtgaccgaa atcacagcca gtagctttgt ggtctcctgg gtctcagctt ccgacaccgt 2161 gtcgggattc cgggtggaat atgagctgag tgaggaggga gacgagccac agtacctgga WO 00/09525 PCTIUS99/17712 EPI-109 951 2221 tcttccaagc acagccactt ctgtgaacat ccctgacctg cttcctggcc gaaaatacat 2281 tgtaaatgtc tatcagatat ctgaggatgg ggagcagagt ttgatcctgt ctacttcaca 2341 aacaacagcg cctgatgccc ctcctgaccc gactgtggac caagttgatg acacctcaat 2401 tgttgttcgc tggagcagac cccaggctcc catcacaggg tacagaatag tctattcgcc 2461 atcagtagaa ggtagcagca cagaactcaa ccttcctgaa actgcaaact ccgtcaccct 2521 cagtgacttg caacctggtg ttcagtataa catcactatc tatgctgtgg aagaaaatca 2581 agaaagtaca cctgttgtca ttcaacaaga aaccactggc accccacgct cagatacagt 2641 gccctctccc agggacctgc agtttgtgga agtgacaqac gtgaaggtca ccatcatgtg 2701 gacaccgcct gagagtgcag tgaccggcta ccgtgtggat gtgatccccg tcaacctgcc 2761 tggcgagcac gggcagaggc tgcccatcag caggaacacc tttgcagaag tcaccgggct 2821 gtcccctggg gtcacctatt acttcaaagt ctttgcagtg agccatggga gggagagcaa 2881 gcctctgact gctcaacaga caaccaaact ggatgctccc actaacctcc agtttgtcaa 2941 tgaaactgat tctactgtcc tggtgagatg gactccacct cgggcccaga taacaggata 3001 ccgactgacc gtgggcctta cccgaagagg ccagcccagg cagtacaatg tgggtccctc 3061 tgtctccaag taccccctga ggaatctgca gcctgcatct gagtacaccg tatccctcgt 3121 ggccataaag ggcaaccaag agagccccaa agccactgga gtctttacca cactgcagcc 3181 tgggagctct attccacctt acaacaccga ggtgactgag accaccatcg tgatcacatg 3241 gacgcctgct ccaagaattg gttttaagct gggtgtacga ccaagccagg gaggagaggc 3301 accacgagaa gtgacttcag actcaggaag catcgttgtg tccggcttga ctccaggagt 3361 agaatacgtc tacaccatcc aagtcctgag agatggacag gaaagagatg cgccaattgt 3421 aaacaaagtg gtgacacca.t tgtctccacc aacaaacttg catctggagg caaaccctga 3481 cactggagtg ctcacagtct cctgggagag gagcaccacc ccagacatta ctggttatag 3541 aattaccaca acccctacaa acggccagca gggaaattct ttggaagaag tggtccatgc 3601 tgatcagagc tcctgcactt ttgataacct gagtcccggc ctggagtaca atgtcagtgt 3661 ttacactgtc aaggatgaca aggaaagtgt ccctatctct gataccatca tcccagctgt 3721 tcctcctccc actgacctgc gattcaccaa cattggtcca gacaccatgc gtgtcacctg 3781 ggctccaccc ccatccattg atttaaccaa cttcctggtg cgttactcac ctgtgaaaaa 3841 tgaggaagat gttgcagagt tgtcaatttc tccttcagac aatgcagtgg tcttaacaaa 3901 tctcctgcct ggtacagaat atgtagtgag tgtctccagt gtctacgaac aacatgagag 3961 cacacctctt agaggaagac agaaaacagg tcttgattcc ccaactggca ttgacttttc 4021 tgatattact gccaactctt ttactgtgca ctggattgct cctcgagcca ccatcactgg 4081 ctacaggatc cgccatcatc ccgagcactt cagtgggaga cctcgagaag atcgggtgcc 4141 ccactctcgg aattccatca ccctcaccaa cctcactcca ggcacagagt atgtggtcag 4201 catcgttgct cttaatggca gagaggaaag tcccttattg attggccaac aatcaacagt 4261 ttctgatgtt ccgagggacc tggaagttgt tgctgcgacc cccaccagcc tactgatcag 4321 ctgggatgct cctgctgtca cagtgagata ttacaggatc acttacggag aaacaggagg 4381 aaatagccct gtccaggagt tcactgtgcc tgggagcaag tctacagcta ccatcagcgg 4441 ccttaaacct ggagttgatt ataccatcac tgtgtatgct gtcactggcc gtggagacag 4501 ccccgcaagc agcaagccaa tttccattaa ttaccgaaca gaaattgaca aaccatccca 4561 gatgcaagtg accgatgttc aggacaacag cattagtgtc aagtggctgc cttcaagttc 4621 ccctgttact ggttacagag taaccaccac tcccaaaaat ggaccaggac caacaaaaac 4681 taaaactgca ggtccagatc aaacagaaat gactattgaa ggcttgcagc ccacagtgga 4741 gtatgtggtt agtgtctatg ctcagaatcc aagcggagag agtcagcctc tggttcagac 4801 tgcagtaacc aacattgatc gccctaaagg actggcattc actgatgtgg atgtcgattc 4861 catcaaaatt gcttgggaaa gcccacaggg gcaagtttcc aggtacaggg tgacctactc 4921 gagccctgag gatggaatcc atgagctatt ccctgcacct gatggtgaag aagacactgc 4981 agagctgcaa ggcctcagac cgggttctga gtacacagtc agtgtggttg ccttgcacga 5041 tgatatggag agccagcccc tgattggaac ccagtccaca gctattcctg caccaactga 5101 cctgaagttc actcaggtca cacccacaag cctgagcgcc cagtggacac cacccaatgt 5161 tcagctcact ggatatcgag tgcgggtgac ccccaaggag aagaccggac caatgaaaga 5221 aatcaacctt gctcctgaca gctcatccgt ggttgtatca ggacttatgg tggccaccaa 5281 atatgaagtg agtgtctatg ctcttaagga cactttgaca agcagaccag ctcagggtgt 5341 tgtcaccact ctggagaatg tcagcccacc aagaagggct cgtgtgacag atgctactga 5401 gaccaccatc accattagct ggagaaccaa gactgagacg atcactggct tccaagttga 5461 tgccgttcca gccaatggcc agactccaat ccagagaacc atcaagccag atgtcagaag 5521 ctacaccatc acaggtttac aaccaggcac tgactacaag atctacctgt acaccttgaa 5581 tgacaatgct cggagctccc ctgtggtcat cgacgcctcc actgccattg atgcaccatc 5641 caacctgcgt ttcctggcca ccacacccaa ttccttgctg gtatcatggc agccgccacg 5701 tgccaggatt accggctaca tcatcaagta tgagaagcct gggtctcctc ccagagaagt 5761. ggtccctcgg ccccgccctg gtgtcacaga ggctactatt actggcctgg aaccgggaac 5821 cgaatataca atttatgtca ttgccctgaa gaataatcag aagagcgagc ccctgattgg 5881 aaggaaaaag acagacgagc ttccccaact ggtaaccctt ccacacccca atcttcatgg 5941 accagagatc ttggatgttc cttccacagt tcaaaagacc cctttcgtca cccaccctgg 6001 gtatgacact ggaaatggta ttcagcttcc tggcacttct ggtcagcaac ccagtgttgg 6061 gcaacaaatg atctttgagg aacatggttt taggcggacc acaccgccca caacggccac 6121 ccccataagg cataggccaa gaccataccc gccgaatgta ggacaagaag ctctctctca 6181 gacaaccatc tcatgggccc cattccagga cacttctgag tacatcattt catgtcatcc 6241 tgttggcact gatgaagaac ccttacagtt cagggttcct ggaacttcta ccagtgccac WO 00/09525 PCT/US99/17712 EPI-109 952 6301 tctgacaggc ctcaccagag gtgccaccta caacatcata gtggaggcac tgaaagacca 6361 gcagaggcat aaggttcggg aagaggttgt taccgtgggc aactctgtca acgaaggctt 6421 gaaccaacct acggatgact cgtgctttga cccctacaca gtttcccatt atgccgttgg 6481 agatgagtgg gaacgaatgt ctgaatcagg ctttaaactg ttgtgccagt gcttaggctt 6541 tggaagtggt catttcagat gtgattcatc tagatggtgc catgacaatg gtgtgaacta 6601 caagattgga gagaagtggg accgtcaggg agaaaatggc cagatgatga gctgcacatg 6661 tcttgggaac ggaaaaggag aattcaagtg tgaccctcat gaggcaacgt gttacgatga 6721 tgggaagaca taccacgtag gagaacagtg gcagaaggaa tatctcggtg ccatttgctc 6781 ctgcacatgc tttggaggcc agcggggctg gcgctgtgac aactgccgca gacctggggg 6841 tgaacccagt cccgaaggca ctactggcca gtcctacaac cagtattctc agagatacca 6901 tcagagaaca aacactaatg ttaattgccc aattgagtgc ttcatgcctt tagatgtaca 6961 ggctgacaga gaagattccc gagagtaaat catctttcca atccagagga acaagcatgt 7021 ctctctgcca agatccatct aaactggagt gatgttagca gacccagctt agagttcttc 7081 tttctttctt aagccctttg ctctggagga agttctccag cttcagctca actcacagct 7141 tctccaagca tcaccctggg agtttcctga gggttttctc ataaatgagg gctgcacatt 7201 gcctgttctg cttcgaagta ttcaataccg ctcagtattt taaatgaagt gattctaaga 7261 tttggtttgg gatcaatagg aaagcatatg cagccaacca agatgcaaat gttttgaaat 7321 gatatgacca aaattttaag taggaaagtc acccaaacac ttctgctttc acttaagtgt 7381 ctggcccgca atactgtagg aacaagcatg atcttgttac tgtgatattt taaatatcca 7441 cagtactcac tttttccaaa tgatcctagt aattgcctag aaatatcttt ctcttacctg 7501 ttatttatca atttttccca gtatttttat acggaaaaaa ttgtattgaa aacacttagt 7561 atgcagttga taagaggaat ttggtataat tatggtgggt gattattttt tatactgtat 7621 gtgccaaagc tttactactg tggaaagaca actgttttaa taaaagattt acattccaca (2) INFORMATION FOR SEQ ID NO:2699: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2699 1 cctctctcgg ctagacgagc ttccccaact ggtaaccctt ccacacccca atcttcatgg 61 accagagatc ttggatgttc cttccacagt tcaaaagacc cctttcgtca cccaccctgg 121 gtatgacact ggaaatggta ttcagcttcc tggcacttct ggtcagcaac ccagtgttgg 181 gcaacaaatg atctttgagg aacatggttt taggcggacc acaccgccca caacggccac 241 ccccataagg cataggccaa gaccataccc gccgaatgta ggtgaggaaa tccaaattgg 301 tcacattccc agggaagatg agactatca cctgtaccca cacggtccgg gactcaatcc 361 aaatgcctct acaggacaag aagctctctc tcagacaacc atctcatggg ccccattcca 421 ggacacttct gagtacatca tttcatgtca tcctgttggc actgatgaag aacccttaca 481 ggtaattaat tgttctcttc acttctcatg gggcagcaca gaaaggaata agttaggtaa 541 ctgaagtgac cagccctcga ataaaaagtg gcttcatggc cgggtgtgat ggctcacgcc 601 tgtaatccca gcactttggg aggccgaggc aggtggatca tttgaggtta ggagttcaag 661 accagcctgg ccaacatggt gaaacctcgt ctcttgaaaa aaaaaaaaaa aaagtggctc 721 caccttttag aacctctta aagatggcac atttaagccc tgcttttttt tttttttaaa 781 tcccaatatg gctctacttt ggaggacata ccagagagtc actagccttt tatttccata 841 gagaaaatga aactatttct cttattctca cacatttgag gttccttttt gagtaagata 901 gatggttcta gaaaagaaag aaagatattc tacctgaatt tccatttgtg tgcagaagtc 961 taaaacacta cctttacgat ttgtccttga agaaccccac tatctacaac atatctaaag 1021 aaaaaaaaaa acagcgaagc tgtgcatagc ag 1 atcaaacaga aatgactatt gaaggcttgc agcccacagt ggagtatgtg gttagtgtct 61 atgctcagaa tccaagcgga gagagtcagc ctctggttca gactgcagta accagtacgt 121 aaccactgct tggtttccat tttcaaagtc aaattttgtt cttgggtgtc tgaatgccca 181 cgacatgtct tttgcaatta cacataggga aagtgaactt gttggttagt ttatgtcttg 241 agctgagccc tttacgaaca tcttttttcc ttctcagtgc caagcgagga atttacagag 301 aaagaagttg tgaaaccacc atagttagtt gctgtgcttt gaatttcttt ttgctcaaat 361 ggcctcagcg aaatcttatt tgcctatagc aaatctacaa aaaattttcc tagaccgtct 421 tttctacaac tggatggtaa agttgattga agtgtgcctc atgtagcttt atgtttgggg 481 catttgaagg gctatggctg gaccagagtg taatataaat gcttaataga gaggggaaaa 541 gaagagtgta agaaccatta tagggctggg ctcacgcctg taatcccagc attttgggag 601 gctgaggcgg atcacgaggt caggagttcg agaccagcct gaccaacatg gtgaaacccc 661 atctctacta aaaatacaaa aattagccag tcgcggtggc acgtgcctgt aatcccagct 721 actcacggag gctgaggcag aagaatcact cggacccagc aggcagaagt tgcagtgagc 781 caagatcatg cctctgcacc ccagcctagg tgatagagtg agactccatc tcaaaaaaaa 841 acaaaacaaa acaattataa caatttgaat ctgaaccata tgcaaatcag ctttaccact 901 tccaaggtat aagaaaatcc aggtctatga gactaacatc acattgtaaa aatcaaatcg 961 tggtagaata cctttaaatt aatataaata catccccatt gtggggacat tttgcagggt 1021 atctgcttat ctcacataca ccatgtttta ataagtgatg caacattgca tattttctaa 1081 accaagaaaa attaagcaag tgtttaagtg attttcctt tgatagtggg ttaattggac 1141 ttcatcaaag aaaatggtat ctgcaaaact gctttgcatg ttataaaaat gcttatttca WO 00/09525 PCT/US99/17712 EPI-109 953 1201 caacttgctt tcacataacc tcttaccatt aatttgccta acagacattg atcgccctaa 1261 aggactggca ttcactgatg tggatgtcga ttccatcaaa attgcttggg aaagcccaca 1321 ggggcaagtt tccaggtaca gggtgaccta ctcgagccct gaggatggaa tccatgagct 1381 attccctgca cctgatggtg aagaagacac tgcagagctg caaggcctca gaccgggttc 1441 tgagtacaca gtcagtgtgg ttgccttgca cgatgatatg gagagccagc ccctgattgg 1501 aacccagtcc acaggtatat qgttaattgc acacaggtgc catgggagca gcggctttat 1561 gcctactgaa tgaattatgc ttcactgggc tattgattcc cgtgtaaggg tgaaaaagaa 1621 ttattaggaa aqatcctctt taaagaggaa tggtaagaaa caataaaact taggtgatat 1681 ttaaggaaac aagtctgatt aaaagaaatt ttggagtatc ctggcttata cacaagacca 1741 taaagcaaga catttgaaga ggatactaaa gttgtggatt atttcctaag ctctgactcc 1801 ctgtgattac cctcactatg tataaagaaa agaagtttgg cattacagag cttacttata 1861 aaaaggaacc caaactcggg catttcatag cagcatgatt ctgagcacac gtgggtaaga 1921 cctttcttct ctggttagat atcatatgct ggtgtataat tagcttaaat gattgtgatt 1981 tagacaceta ggaaataatc aatagggcaa ttgctttcca taatacttta tcttcttgtg 2041 ctttatttct gaagcagagt agaatgctaa agatgtatcc tagtgacagc ataaacccta 2101 gaggtgacag tctgtattat tgcttttcgc ttctcttttc tgcttctgtt gggagccagt 2161 tttcttctta cgccgcatta cagagagaac gtcaaattta gcaagccata tctgccatag 2221 gtccaaataa agagacaata aaaattattc tctctttttt ggatggaata ctgcgtgaaa 2281 tggttatcca tacaaagata ctttatgtag aatagaaaaa ggaggccggg tgcagtggct 2341 cacacatgta atcctagtgc tttgggaggc taagccggga gcactgattg aggccaggag 2401 ttcatgatca gcctgggcaa tgaagtgaga ccccgtctct acaaaaaaat atgaaaaaat 2461 tagcgaggtg tggtgacaca tgcctgtagt cccagctact caagaggctg aggtagagga 2521 tcacttgagc ctacgagttc aaggctgcag tgagctatga taactccact gcactgctgc 2581 ctggatgaca cagagagacc gtttctaaat taattaatta acaattttaa gaaagaaaaa 2641 gggccattgc ttatttttcc atacaaaagt aaaataaatc ataatggcca ataagccaat 2701 gtaacttttt tttttaaggg aaagcaaaac ttgtaaaacc taaaatctct tagagttttg 2761 gcatttaccc aaatgttttc agtgattctg agaattggtg gatataaaac acatttctca 2821 gcaaacactt tcttcatttt gcatccctta ctgtactttc ttgtactgaa tctttgcttg 2881 accagggaac ccacctagcc caacaagaac aatccattct acttcttgga actacgttta 2941 ttttcctttt cccccatttc ctataagata acctctaacc aatgacaatc tcgacagcta 3001 ttcctgcacc aactgacctg aagttcactc aggtcacacc cacaagcctg agcgcccagt 3061 ggacaccacc caatgttcag ctcactggat atcgagtgcg ggtgaccccc aaggagaaga 3121 ccggaccaat gaaagaagtc aaccttgctc ctgacagctc atccgtggtt gtatcaggac 3181 ttatc 1 ctgcactttt gataacctga gtcccggcct ggagtacaat gtcagtgttt acactgtcaa 61 ggatgacaag gaaagtgtc c ctatctctga taccatcatc ccaggtaata gaaaataagc 121 tgctatcctg agagtgacat tccaataaga gtggggatta gcatcttaat ccccagatgc 181 ttaagggtgt caactatatt tgggatttaa ttccgatctc ccagctgcac tttccaaaac 241 caagaagtca aagcagcgat ttggacaaaa tgcttgctgt taacactgct ttactgtctg 301 tgcttcactg ggatgctgtg tgttgcagcg agtatgtaat ggagtggcag ccatggcttt 361 aactctgtat tgtctgctca catggaagta tgactaaaac actgtcacgt gtctgtactc 421 agtactgata ggctcaaagt aatatggtaa atgcatccca tcagtacatt tctgcccgat 481 tttacaatcc atatcaattt ccaacagctg cctatttcat cttgcagttt caaatccttc 541 tttttgaaaa ttggatttta aaaaaaagtt aagtaaaagt cacaccttca gggttgttct 601 ttcttgtggc cttgaaagac aacattgcaa aggcctgtcc taaggatagg cttgtttgtc 661 cattgggtta taacataatg aaagcattgg acagatcgtg tccccctttg gactcttcag 721 tagaatgctt ttactaacgc taattacatg ttttgattat gaatgaacct aaaatagtgg 781 caatggcctt aacctaggcc tgtctttcct cagcctgaat gtgcttttga atggcacatt 841 tcacaccata cattcataat gcattagcgt tatggccatg atgttgtcat gagttttgta 901 tgggagaaaa aaaatcaatt tatcacccat ttattatttt ttccggttgt tcatgcaagc 961 ttattttcta ctaaaacagt tttggaatta ttaaaagcat tgctgatact tacttcagat 1021 attatgtcta ggctctaaga atggtttcga catcctaaac agccatatga tttttaggaa 1081 tctgaacagt tcaaattgta ccctttaagg atgttttcaa aatgtaaaaa atatatatat 1141 atatatatat tccctaaaag aatattcctg tttattcttc tagggaagca aactgttcat 1201 gatgcttagg aagtcttttc agagaattta aaacagattg catattacca tcattgcttt 1261 aacattccac caattttact actagtaacc tgatatacac tgctttattt tttcctcttt 1321 ttttccctct attttccttt tgcctccccc tccctttgct ttgtaactca atagaggtgc 1381 cccaactcac tgacctaagc tttgttgata taaccgattc aagcatcggc ctgaggtgga 1441 ccccgctaaa ctcttccacc attattgggt accgcatcac agtagttgCg gcaggagaag 1501 gtatccctat ttttgaagat tttgtggact cctcagtagg atactacaca gtcacagggc 1561 tggagccggg cattgactat gatatcagcg ttatcactct cattaatggc ggcgagagtg 1621 cccctactac actgacacaa caaacgggtg aattttgaaa acttctgcgt ttgagacata 1681 gatggtgttg catgctgcca ccagttactc cggttaaata tggatgtttc atgggggaag 1741 tcagcaattg gccaaagatt cagataggtg gaattggggg gataaggaat caaatgcatc 1801 tgctaaactg attggagaaa aacacatgca atatcttcag tacactctca tttaaaccac 1861 aagtagatat aaagcctaga gaaatacaga tgtctgctct gttaaatata aaatagcaaa 1921 tgttcattca atttgaagac ctagaatttt tcttcttaaa taccaaacac gaataccaaa 1981 ttgcgtaagt accaattgat aagaatatat caccaaaatg taccatcatg ctcttccttc WO 00/09525 PCT/US99/17712 EPI-109 954 2041 taccctttga taaactctac catgctcctt ctttgtagct aaaaacccat caaaatttag 2101 ggtagagtgg atgggcattg ttttgaggta ggagaaaagt aaacttggga ccattctagg 2161 ttttgttgct gtcactaggt aaagaaacac ctctttaacc acagtctggg gacaagcatg 2221 caacatttta aaggttctct gctgtgcatg ggaaaagaaa catgctgaga accaatttgc 2281 atgaacatgt tcacttgtaa gtagaattca ctgaatggaa ctgtagctct agatatctca 2341 catgggggga agtttaggac cctcttgtct ttttgtctgt gtgcatgtat ttctttgtaa 2401 agtactgcta tgtttctctt tgctgtgtgg caacttaagc ctcttcggcc tgggataaaa 2461 taatctgcag tggtattaat aatgtacata aagtcaacat atttgaaagt agattaaaat 2521 cttttttaaa tatatcaatg atqgcaaaaa ggttaaaggg ggcctaacag tactgtgtgt 2581 agtgttttat ttttaacagt agtacactat aacttaaaat agacttagat tagactgttt 2641 gcatgattat gattctgttt cctttatgca tgaaatattg attttacctt tccagctact 2701 tcgttagctt taattttaaa atacattaac tgagtcttcc ttcttgttcg aaaccagctg 2761 ttcctcctcc cactgacctg cgattcacca acattggtcc agacaccatg cgtgtcacct 2821 ggg 1 gaagagcaag aggcaggctc agcaaatggt tcagccccag tccccggtgg ctgtcagtca 61 aagcaagccc ggttgttatg acaatggaaa acactatcag ataaatcaac agtgggagcg 121 gacctaccta ggtaatgtgt tggtttgtac ttgttatgga ggaagccgag gttttaactg 181 cgaaagtaaa cctgaagctg aagagacttg ctttgacaag tacactggga acacttaccg 241 agtgggtgac acttatgagc gtcctaaaga ctccatgatc tgggactgta cctgcatcgg 301 ggctgggcga gggagaataa gctgtaccat cgcaaaccgc tgccatgaag ggggtcagtc 361 ctacaagatt ggtgacacct ggaggagacc acatgagact ggtggttaca tgttagagtg 421 tgtgtgtctt ggtaatggaa aaggagaatg gacctgcaag cccatagctg agaagtgttt 481 tgatcatgct gctgggactt cctatgtggt cggagaaacg tgggagaagc cctaccaagg 541 ctggatgatg gtagattgta cttgcctggg agaaggcagc ggacgcatca cttgcacttc 601 tagaaataga tgcaacgatc aggacacaag gacatcctat agaattggag acacctggag 661 caagaaggat aatcgaggaa acctgctcca gtgcatctgc acaggcaacg gccgaggaga 721 gtggaagtgt gagaggcaca cctctgtgca gaccacatcg agcggatctg gccccttcac 781 cgatgttcgt gcagctgttt accaaccgca gcctcacccc cagcctcctc cctatggcca 841 ctgtgtcaca gacagtggtg tggtctactc tgtggggatg cagtggttga agacacaagg 901 aaataagcaa atgctttgca cgtgcctggg caacggagtc agctgccaag agacagctgt 961 aacccagact tacggtggca acttaaatgg agagccatgt gtcttaccat tcacctacaa 1021 tggcaggacg ttctactcct gcaccacgga agggcgacag gacggacatc tttggtgcag 1081 cacaacttcg aattatgagc aggaccagaa atactctttc tgcacagacc acactgtttt 1141 ggttcagact caaggaggaa attccaatgg tgccttgtgc cacttcccct tcctatacaa 1201 caaccacaat tacactgatt gcacttctga gggcagaaga gacaacatga agtggtgtgg 1261 gaccacacag aactatgatg ccgaccagaa gtttgggttc tgccccatgg ctgcccacga 1321 ggaaatctgc acaaccaatg aaggggtcat gtaccgcatt ggagatcagt gggataagca 1381 gcatgacatg ggtcacatga tgaggtgcac gtgtgttggg aatggtcgtg gggaatggac 1441 atgcattgcc tactcgcaac ttcgagatca gtgcattgtt gatgacatca cttacaatgt 1501 gaacgacaca ttccacaagc gtcatgaaga ggggcacatg ctgaactgta catgcttcgg 1561 tcagggtcgg ggcaggtgga agtgtgatcc cgtcgaccaa tgccaggatt cagagactgg 1621 gacgttttat caaattggag attcatggga gaagtatgtg catggtgtca gataccagtg 1681 ctactgctat ggccgtggca ttggggagtg gcattgccaa cctttacaga cctatccaag 1741 ctcaagtggt cctgtcgaag tatttatcac tgagactccg agtcagccca actcccaccc 1801 catccagtgg aatgcaccac agccatctca catttccaag tacattctca ggtggagacc 1861 taaaaattct gtaggccgtt ggaaggaagc taccatacca ggccacttaa actcctacac 1921 catcaaaggc ctgaagcctg gtgtggtata cgagggccag ctcatcagca tccagcagta 1981 cggccaccaa gaagtgactc gctttgactt caccaccacc agcaccagca cacctgtgac 2041 cagcaacacc gtgacaggag agacgactcc cttttctcct cttgtggcca cttctgaatc 2101 tgtgaccgaa atcacagcca gtagctttgt ggtctcctgg gtctcagctt ccgacaccgt 2161 gtcgggattc cgggtggaat atgagctgag tgaggaggga gatgagccac agtacctgga 2221 tcttccaagc acagccactt ctgtgaacat ccctgacctg cttcctggcc gaaaatacat 2281 tgtaaatgtc tatcagatat ctgaggatgg ggagcagagt ttgatcctgt ctacttcaca 2341 aacaacagcg cctgatgccc ctcctgaccc gactgtggac caagttgatg acacctcaat 2401 tgttgttcgc tggagcagac cccaggctcc catcacaggg tacagaatag tctattcgcc 2461 atcagtagaa ggtagcagca cagaactcaa ccttcctgaa actgcaaact ccgtcaccct 2521 cagtgacttg caacctggtg ttcagtataa catcactatc tatgctgtgg aagaaaatca 2581 agaaagtaca cctgttgtca ttcaacaaga aaccactggc accccacgct cagatacagt 2641 gccctctccc agggacctgc agtttgtgga agtgacagac gtgaaggtca ccatcatgtg 2701 gacaccgcct gagagtgcag tgaccggcta ccgtgtggat gtgatccccg tcaacctgcc 2761 tggcgagcac gggcagaggc tgcccatcag caggaacacc tttgcagaag tcaccgggct 2821 gtcccctggg gtcacctatt acttcaaagt ctttgcagtg agccatggga gggagagcaa 2881 gcctctgact gctcaacaga caaccaaact ggatgctccc actaacctcc agtttgtcaa 2941 tgaaactgat tctactgtcc tggtgagatg gactccacct cgggcccaga taacaggata 3001 ccgactgacc gtgggcctta cccgaagagg ccagcccagg cagtacaatg tgggtccctc 3061 tgtctccaag taccccctga ggaatctgca gcctgcatct gagtacaccg tatccctcgt 3121 ggccataaag ggcaaccaag agagccccaa agccactgga gtctttacca cactgcagcc 3181 tgggagctct attccacctt acaacaccga ggtgactgag accaccatcg tgatcacatg WO 00/09525 PCTIUS99/17712 EPI-109 955 3241 gacgcctgct ccaagaattg gttttaaact gggtgtacga ccaagccagq gaggagaggc 3301 accacgagaa gtgacttcag actcaggaag catcgttgtg tccggcttga ctccaggagt 3361 agaatacgtc tacaccatcc aagtcctgag agatggacag gaaagagatg cgccaattgt 3421 aaacaaagtg gtgacaccat tgtctccacc aacaaacttg catctggagg caaaccctga 3481 cactggagtg ctcacagtct cctgggagag gagcaccacc ccagacatta ctggttatag 3541 aattaccaca acccctacaa acggccagca gggaaattct ttggaagaag tggtccatgc 3601 tgatcagagc tcctgcactt ttgataacct gagtcccggc ctggagtaca atgtcagtgt 3661 ttacactgtc aaggatgaca aggaaagtgt ccctatctct gataccatca tcccagctgt 3721 tcctcctccc actgacctgc gattcaccaa cattggtcca gacaccatgc gtgtcacctg 3781 ggctccaccc ccatccattg atttaaccaa cttcctggtg cgttactcac ctgtgaaaaa 3841 tgaggaagat gttgcagagt tgtcaatttc tccttcagac aatgcagtgg tcttaacaaa 3901 tctcctgcct ggtacagaat atgtagtgag tgtctccagt gtctacgaac aacatgagag 3961 cacacctctt agaggaagac agaaaacagg tcttgattcc ccaactggca ttgacttttc 4021 tgatattact gccaactctt ttactgtgca ctggattgct cctcgagcca ccatcactgg 4081 ctacaggatc cgccatcatc ccgagcactt cagtgggaga cctcgagaag atcgggtgcc 4141 ccactctcgg aattccatca ccctcaccaa cctcactcca ggcacagagt atgtggtcag 4201 catcgttgct cttaatggca gagaggaaag tcccttattg attggccaac aatcaacagt 4261 ttctgatgtt ccgagggacc tggaagttgt tgctgcgacc cccaccagcc tactqatcag 4321 ctgggatgct cctgctgtca cagtgagata ttacaggatc acttacggag aaacaggagg 4381 aaatagccct gtccaggagt tcactgtgcc tgggagcaag tctacagcta ccatcagcgg 4441 ccttaaacct ggagttgatt ataccatcac tgtgtatgct gtcactggcc gtggagacag 4501 ccccgcaagc agcaagccaa tttccattaa ttaccgaaca gaaattgaca aaccatccca 4561 gatgcaagtg accgatgttc aggacaacag cattagtgtc aagtggctgc cttcaagttc 4621 ccctgttact ggttacagag taaccaccac tcccaaaaat ggaccaggac caacaaaaac 4681 taaaactgca ggtccagatc aaacagaaat gactattgaa ggcttgcagc ccacagtgga 4741 gtatgtggtt agtgtctatg ctcagaatcc aagcggagag agtcagcctc tggttcagac 4801 tgcagtaacc aacattgatc gccctaaagg actggcattc actgatgtgg atgtcgattc 4861 catcaaaatt gcttgggaaa gcccacaggg gcaagtttcc aggtacaggg tgacctactc 4921 gagccctgag gatggaatcc atgagctatt ccctgcacct gatggtgaag aagacactgc 4981 agagctgcaa ggcctcagac cgggttctga gtacacagtc agtgtggttg ccttgcacga 5041 tgatatggag agccagcccc tgattggaac ccagtccaca gctattcctg caccaactga 5101 cctgaagttc actcaggtca cacccacaag cctgagcgcc cagtggacac cacccaatgt 5161 tcagctcact ggatatcgag tgcgggtgac ccccaaggag aagaccggac caatgaaaga 5221 aatcaacctt gctcctgaca gctcatccgt ggttgtatca ggacttatgg tggccaccaa 5281 atatgaagtg agtgtctatg ctcttaagga cactttgaca agcagaccag ctcagggtgt 5341 tgtcaccact ctggagaatg tcagcccacc aagaagggct cgtgtgacag atgctactga 5401 gaccaccatc accattagct ggagaaccaa gactgagacg atcactggct tccaagttga 5461 tgccgttcca gccaatggcc agactccaat ccagagaacc atcaagccag atgtcagaag 5521 ctacaccatc acaggtttac aaccaggcac tgactacaag atctacctgt acaccttgaa 5581 tgacaatgct cggagctccc ctgtggtcat cgacgcctcc actgccattg atgcaccatc 5641 caacctgcgt ttcctggcca ccacacccaa ttccttgctg gtatcatggc agccgccacg 5701 tgccaggatt accggctaca tcatcaagta tgagaagcct gggtctcctc ccagagaagt 5761 ggtccctcgg ccccgccctg gtgtcacaga ggctactatt actggcctgg aaccgggaac 5821 cgaatataca atttatgtca ttgccctgaa gaataatcag aagagcgagc ccctgattgg 5881 aaggaaaaag acagacgagc ttccccaact ggtaaccctt ccacacccca atcttcatgg 5941 accagagatc ttggatgttc cttccacagt tcaaaagacc cctttcgtca cccaccctgg 6001 gtatgacact ggaaatggta ttcagcttcc tggcacttct ggtcagcaac ccagtgttgg 6061 gcaacaaatg atctttgagg aacatggttt taggcggacc acaccgccca caacggccac 6121 ccccataagg cataggccaa gaccataccc gccgaatgta ggacaagaag ctctctctca 6181 gacaaccatc tcatgggccc cattccagga cacttctgag tacatcattt catgtcatcc 6241 tgttggcact gatgaagaac ccttacagtt cagggttcct ggaacttcta ccagtgccac 6301 tctgacaggc ctcaccagag gtgccaccta caacatcata gtggaggcac tgaaagacca 6361 gcagaggcat aaggttcggg aagaggttgt taccgtgggc aactctgtca acgaaggctt 6421 gaaccaacct acggatgact cgtgctttga cccctacaca gtttcccatt atgccgttgg 6481 agatgagtgg gaacgaatgt ccgaatcagg ctttaaactg ttgtgccagt gcttaggctt 6541 tggaagtggt catttcagat gtgattcatc tagatggtgc catgacaatg gtgtgaacta 6601 caagattgga gagaagtggg accgtcaggg agaaaatggc cagatgatga gctgcacatg 6661 tcttgggaac ggaaaaggag aattcaagtg tgaccctcat gaggcaacgt gttacgatga 6721 tgggaagaca taccacgtag gagaacagtg gcagaaggaa tatctcggtg ccatttgctc 6781. ctgcacatgc tttggaggcc agcggggctg gcgctgtgac aactgccgca gacctggggg 6841 tgaacccagt cccgaaggca ctactggcca gtcctacaac cagtattctc agagatacca 6901 tcagagaaca aacactaatg ttaattgccc aattgagtgc ttcatgcctt tagatgtaca 6961 ggctgacaga gaagattccc gagagtaaat catctttcca atccagagga acaagcatgt 7021 ctctctgcca agatccatct aaactggagt gatgttagca gacccagctt agagttcttc 7081 tttctttctt aagccctttg ctctggagga agttctccag cttcagctca actcacagct 7141 tctccaagca tcaccctggg agtttcctga gggttttctc ataaatgagg gctgcacatt 7201 gcctgttctg cttcgaagta ttcaataccg ctcagtattt taaatgaagt gattctaaga 7261 tttggtttgg gatcaaagg aaagcatatg cagccaacca agatgcaaat gttttgaaat WO 00/09525 PCT/US99/17712 EPI-109 956 7321 gatatgacca aaattttaag taggaaagtc acccaaacac ttctgctttc acttaagtgt 7381 ctggcccgca atactgtagg aacaagcatg atcttgttac tgtgatattt taaatatcca 7441 cagtactcac tttttccaaa tgatcctagt aattgcctag aaatatcttt ctcttacctg 7501 ttatttatca atttttccca gtatttttat acggaaaaaa ttgtattgaa aacacttagt 7561 atgcagttga taagaggaat ttggtataat tatggtgggt gattattttt tatactgtat 7621 gtgccaaagc tttactactg tggaaagaca actgttttaa taaaagattt acattccaca (2) INFORMATION FOR SEQ ID NO:2700: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2700 1 ctgctcctgc gcggcagctg ctttagaagg tctcgagcct cctgtacctt cccagggatg 61 aaccgggcct tccctctgga aggcgagggt tcgggccaca gtgagcgagg gccagggcgg 121 tgggcgcgcg cagagggaaa ccggatcagt tgagagagaa tcaagagtag cggatgaggc 181 gcttgtgggg cgcggcccgg aagccctcgg gcgcgggctg ggagaaggag tgggcggagg 241 cgccgcagga ggctcccggg gcctggtcgg gccggctggg ccccgggcgc agtggaagaa 301 agggacgggc ggtgcccggt tgggcgtcct ggccagctca ccttgccctg gcggctcgcc 361 ccgcccggca cttgggagga gcagggcagg gcccgcggcc tttgcattct gggaccgccc 421 ccttccattc ccgggccagc ggcgagcggc agcgacggct ggagccgcag ctacagcatg 481 agagccggtg ccgctcctcc acgcctgcgg acgcgtggcg agcggaggca gcgctgcctg 541 ttcgcgccat gggggcaccg tggggctcgc cgacggcggc ggcgggcggg cggcgcgggt 601 ggcgccgagg ccgggggctg ccatggaccg tctgtgtgct ggcggccgcc ggcttgacgt 661 gtacggcgct gatcacctac gcttgctggg ggcagctgcc gccgctgccc tgggcgtcgc 721 caaccccgtc gcgaccggtg ggcgtgctgc tgtggtggga gcccttcggg gggcgcgata 781 gcgccccgag gccgccccct gactgccggc tgcgcttcaa catcagcggc tgccgcctgc 841 tcaccgaccg cgcgtcctac ggagaggctc aggccgtgct tttccaccac cgcgacctcg 901 tgaaggggcc ccccgactgg cccccgccct ggggcatcca ggcgcacact gccgaggagg 961 tggatctgcg cgtgttggac tacgaggagg cagcggcggc ggcagaagcc ctggcgacct 1021 ccagccccag gcccccgggc cagcgctggg tttggatgaa cttcgagtcg ccctcgcact 1081 ccccggggct gcgaagcctg gcaagtaacc tcttcaactg gacgctctcc taccgggcgg 1141 actcggacgt ctttgtgcct tatggctacc tctaccccag aagccacccc ggcgacccgc 1201 cctcaggcct ggccccgcca ctgtccagga aacaggggct ggtggcatgg gtggtgagcc 1261 actgggacga gcgccaggcc cgggtccgct actaccacca actgagccaa catgtgaccg 1321 tggacgtgtt cggccggggc gggccggggc agccggtgcc cgaaattggg ctcctgcaca 1381 cagtggcccg ctacaagttc tacctggctt tcgagaactc gcagcacctg gattatatca 1441 ccgagaagct ctggcgcaac gcgttgctcg ctggggcggt gccggtggtg ctgggcccag 1501 accgtgccaa ctacgagcgc tttgtgcccc gcggcgcctt catccacgtg gacgacttcc 1561 caagtgcctc ctccctggcc tcgtacctgc ttttcctcga ccgcaacccc gcggtctatc 1621 gccgctactt ccactggcgc cggagctacg ctgtccacat cacctccttc tgggacgagc 1681 cttggtgccg ggtgtgccag gctgtacaga gggctgggga ccggcccaag agcatacgga 1741 acttggccag ctggttcgag cggtgaagcc gcgctcccct ggaagcgacc caggggaggc 1801 caagttgtca gctttttgat cctctactgt gcatctcctt gactgccgca tcatgggagt 1861 aagttcttca aacacccatt tttgctctat gggaaaaaaa cgatttacca attaatatta 1921 ctcagcacag agatgggggc ccggtttcca tattttttgc acagctagca attgggctcc 1981 ctttgctgct gatgggcatc attgtttagg ggtgaaggag ggggttcttc ctcaccttgt 2041 aaccagtgca gaaatgaaat agcttagcgg caagaagccg ttgaggcggt ttcctgaatt 2101 tccccatctg ccacaggcca tatttgtggc ccgtgcagct tccaaatctc atacacaact 2161 gttcccgatt cacgtttttc tggaccaagg tgaagcaaat ttgtggttgt agaaggagcc 2221 ttgttggtgg agagtggaag gactgtggct gcaggtggga ctttgttgtt tggattcctc 2281 acagccttgg ctcctgagaa aggtgaggag ggcagtccaa gaggggccgc tgacttcttt 2341 cacaagtact atctgttccc ctgtcctgtg aatggaagca aagtgctgga ttgtccttgg 2401 aggaaactta agatgaatac atgcgtgtac ctcactttac ataagaaatg tattcctgaa 2461 aagctgcatt taaatcaagt cccaaattca ttgacttagg ggagttcagt atttaatgaa 2521 accctatgga gaatttatcc ctttacaatg tgaatagtca tctcctaatt tgtttcttct 2581 gtctttatgt ttttctataa cctggatttt ttaaatcata ttaaaattac agatgtgaaa 2641 ataaagcaga agcaaccttt ttccctcttc ccagaaaacc agtctgtgtt tacagacaga 2701 agagaaggaa gccatagtgt cacttccaca caattattta tttcatgtct ttactggacc 2761 tgaaatttaa actgcaatgc cagtcctgca ggagtgctgg cattaccctc tgcagaacag 2821 tgaaaggtat tgcactacat tatggaatca tgcaaaaaaa a (2) INFORMATION FOR SEQ ID NO:2701: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: _base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear WO 00/09525 PCT/US99/17712 EPI-109 957 (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2701 1 acgcgtggcg agcggaggca gcgctgcctg ttcgcgccat gggggcaccg tggggctcgc 61 cgacggcggc ggcgggcggg cggcgcgggt ggcgccgagg ccgggggctg ccatggaccg 121 tctgtgtgct ggcggccgcc ggcttgacgt gtacggcgct gatcacctac gcttgctggg 181 ggcagctgcc gccgctgccc tgggcgtcgc caaccccgtc gcgaccggtg ggcgtgctgc 241 tgtggtggga gcccttcggg gggcgcgata gcgccccgag gccgccccct gactgcccgc 301 tgcgcttcaa catcagcggc tgccgcctgc tcaccgaccg cgcgtcctac ggagaggctc 361 aggccgtgct tttccaccac cgcgacctcg tgaaggggcc ccccgactgg cccccgccct 421 ggggcatcca ggcgcacact gccgaggagg tggatctgcg cgtgttggac tacgaggagg 481 cagcggcggc ggcagaagcc ctggcgacct ccagccccag gcccccgggc cagcgctggg 541 tttggatgaa cttcgagtcg ccctcgcact ccccggggct gcgaagcctg gcaagtaacc 601 tcttcaactg gacgctctcc taccgggcgg actcggacgt ctttgtgcct tatggctacc 661 tctaccccag aagccacccc ggcgacccgc cctcaggcct ggccccgcca ctgtccagga 721 aacaggggct ggtggcatgg gtggtgagcc actgggacga gcgccaggcc cgggtccgct 781 actaccacca actgagcca , catgtgaccg tggacgtgtt cggccggggc gggccggggc 841 agccggtgcc cgaaattggg ctcctgcaca cagtggcccg ctacaagttc tacctggctt 901 tcgagaactc gcagcacctg gattatatca ccgagaagct ctggcgcaac gcgttgctcg 961 ctggggcggt gccggtggtg ctgggcccag accgtgccaa ctacgagcgc tttgtgcccc 1021 gcggcgcctt catccacgtg gacgacttcc caagtgcctc ctccctggcc tcgtacctgc 1081 ttttcctcga ccgcaacccc gcggtctatc gccgctactt ccactggcgc cggagctacg 1141 ctgtccacat cacctccttc tgggacgagc cttggtgccg ggtgtgccag gctgtacaga 1201 gggctgggga ccggcccaag agcatacgga acttggccag ctggttcgag cggtag (2) INFORMATION FOR SEQ ID NO:2702: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: _base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2702 1 cagatactct gacccatgga tcccctgggc ccggccaagc cacagtggtc gtggcgctgc 61 tgtctgacca cgctgctgtt tcagctgctg atggctgtgt gtttcttctc ctatctgcgt 121 gtgtctcaag acgatcccac tgtgtaccct aatgggtccc gcttcccaga cagcacaggg 181 acccccgccc actccatccc cctgatcctg ctgtggacgt ggccttttaa caaacccata 241 gctctgcccc gctgctcaga gatggtgcct ggcacggctg actgcaacat cactgccgac 301 cgcaaggtgt atccacaggc agacgcggtc atcgtgcacc accgagaggt catgtacaac 361 cccagtgccc agctcccacg ctccccgagg cggcaggggc agcgatggat ctggttcagc 421 atggagtccc caagccactg ctggcagctg aaagccatgg acggatactt caatctcacc 481 atgtcctacc gcagcgactc cgacatcttc acgccctacg gctggctgga gccgtggtcc 541 ggccagcctg cccacccacc gctcaacctc tcggccaaga ccgagctggt ggcctgggca 601 gtgtccaact gggggccaaa ctccgccagg gtgcgctact accagagcct gcaggcccat 661 ctcaaggtgg acgtgtacgg acgctcccac aagcccctgc cccagggaac catgatggag 721 acgctgtccc ggtacaagtt ctatctggcc ttcgagaact ccttgcaccc cgactacatc 781 accgagaagc tgtggaggaa cgccctggag gcctgggccg tgcccgtggt gctgggcccc 841 agcagaagca actacgagag gttcctgccg cccgacgcct tcatccacgt ggacgacttc 901 cagagcccca aggacctggc ccggtacctg caggagctgg acaaggacca cgcccgctac 961 ctgagctact ttcgctggcg ggagacgctg cggcctcgct ccttcagctg ggcactcgct 1021 ttctgcaagg cctgctggaa actgcaggag gaatccaggt accagacacg cggcatagcg 1081 gcttggttca cctgagaggc ccggcatggg gcctgggctg ccaggg (2) INFORMATION FOR SEQ ID NO:2703: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2703 1 aaggagcaca gttccaggcg gggctgagct agggcgtagc tgtgatttca ggggcacctc 61 tggcggctgc cgtgatttga gaatctcggg tctcttggct gactgatcct gggagactgt 121 ggatgaataa tgctgggcac ggccccaccc ggaggctgcg aggcttgggg gtcctggccg 181 gggtggctct gctcgctgcc ctctggctcc tgtggctgct ggggtcagcc cctcggggta 241 ccccggcacc ccagcccacg atcaccatcc ttgtctggca ctggcccttc actgaccagc 301 ccccagagct gcccagcgac acctgcaccc gctacggcat cgcccgctgc cacctgagtg 361 ccaaccgaag cctgctggcc agcgccgacg ccgtggtctt ccaccaccgc gagctgcaga 421 cccggcggtc ccacctgccc ctggcccagc ggccgcgagg gcagccctgg gtgtgggcct 481 ccatggagtc tcctagccac acccacggcc tcagccacct ccgaggcatc ttcaactggg 541 tgctgagcta ccggcgcgac tcggacatct ttgtgcccta tggccgcctg gagccccact 601 gggggccctc gccaccgctg ccagccaaga gcagggtggc cgcctgggtg gtcagcaact 661 tccaggagcg gcagctgcgt gccaggctgt accggcagct ggcgcctcat ctgcgggtgg WO 00/09525 PCT/US99/17712 EPI-109 958 721 atgtctttgg ccgtgccaat ggacggccac tgtgcgccag ctgcctggtg cccaccgtgg 781 cccagtaccg cttctacctg tcctttgaga actctcagca ccgcgactac attacggaga 841 aattctggcg caacgcactg gtggctggca ctgtgccagt ggtgctgggg cccccacggg 901 ccacctatga ggccttcgtg ccggctgacg ccttcgtgca tgtggatgac tttggctcag 961 cccgagagct ggcggctttc ctcactggca tgaatgagag ccgataccaa cgcttctttg 1021 cctggcgtga caggctccgc gtgcgactgt tcaccgactg gcgggaacgt ttctgtgcca 1081 tctgtgaccg ctacccacac ctaccccgca gccaagtcta tgaggacctt gagggttggt 1141 ttcaggcctg agatccgctg gccgggggag gtgggtgtgg gtggaagggc tgggtgtcga 1201 aatcaaacca ccaggcatcc ggcccttacc ggcaagcagc gggctaacgg gaggctgggc 1261 acagaggtca ggaagcaggg gtggggggtg caggtgggca ctggagcatg cagaggaggt 1321 gagagtggga gggaggtaac gggtgcctgc tgcggcagac gggaggggaa aggctgccga 1381 ggaccctccc caccctgaac aaatcttggg tgggtgaagg cctggctgga agagggtgaa 1441 aggcagggcc cttggggctg gggggcaccc cagcctgaag tttgtggggg ccaaacctgg 1501 gaccccgagc ttcctcggta gcagaggccc tgtggtcccc gagacacagg cacgggtccc 1561 tgccacgtcc atagttctga ggtccctgtg tgtaggctgg ggcggggccc aggagaccac 1621 ggggagcaaa ccagcttgtt ctgggctcag ggagggaggg cggtggacaa taaacgtctg 1681 agcagtgaaa aaaaaaaaaa a (2) INFORMATION FOR SEQ ID NO:2704: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2704 1 ctgctcctgc gcggcagctg ctttagaagg tctcgagcct cctgtacctt cccagggatg 61 aaccgggcct tccctctgga aggcgagggt tcgggccaca gtgagcgagg gccagggcgg 121 tgggcgcgcg cagagggaaa ccggatcagt tgagagagaa tcaagagtag cggatgaggc 181 gcttgtgggg cgcggcccgg aagccctcgg gcgcgggctg ggagaaggag tgggcggagg 241 cgccgcagga ggctcccggg gcctggtcgg gccggctggg ccccgggcgc agtggaagaa 301 agggacgggc ggtgcccggt tgggcgtcct ggccagctca ccttgccctg gcggctcgcc 361 ccgcccggca cttgggagga gcagggcagg gcccgcggcc tttgcattct gggaccgccc 421 ccttccattc ccgggccagc ggcgagcggc agcgacggct ggagccgcag ctacagcatg 481 agagccggtg ccgctcctcc acgcctgcgg acgcgtggcg agcggaggca gcgctgcctg 541 ttcgcgccat gggggcaccg tggggctcgc cgacggcggc ggcgggcggg cggcgcgggt 601 ggcgccgagg ccgggggctg ccatggaccg tctgtgtgct ggcggccgcc ggcttgacgt 661 gtacggcgct gatcacctac gcttgctggg ggcagctgcc gccgctgccc tgggcgtcgc 721 caaccccgtc gcgaccggtg ggcgtgctgc tgtggtggga gcccttcggg gggcgcgata 781 gcgccccgag gccgccccct gactgccggc tgcgcttcaa catcagcggc tgccgcctgc 841 tcaccgaccg cgcgtcctac ggagaggctc aggccgtgct tttccaccac cgcgacctcg 901 tgaaggggcc ccccgactgg cccccgccct ggggcatcca ggcgcacact gccgaggagg 961 tggatctgcg cgtgttggac tacgaggagg cagcggcggc ggcagaagcc ctggcgacct 1021 ccagccccag gcccccgggc cagcgctggg tttggatgaa cttcgagtcg ccctcgcact 1081 ccccggggct gcgaagcctg gcaagtaacc tcttcaactg gacgctctcc taccgggcgg 1141 actcggacgt ctttgtgcct tatggctacc tctaccccag aagccacccc ggcgacccgc 1201 cctcaggcct ggccccgcca ctgtccagga aacaggggct ggtggcatgg gtggtgagcc 1261 actgggacga gcgccaggcc cgggtccgct actaccacca actgagccaa catgtgaccg 1321 tggacgtgtt cggccggggc gggccggggc agccggtgcc cgaaattggg ctcctgcaca 1381 cagtggcccg ctacaagttc tacctggctt tcgagaactc gcagcacctg gattatatca 1441 ccgagaagct ctggcgcaac gcgttgctcg ctggggcggt gccggtggtg ctgggcccag 1501 accgtgccaa ctacgagcgc tttgtgcccc gcggcgcctt catccacgtg gacgacttcc 1561 caagtgcctc ctccctggcc tcgtacctgc ttttcctcga ccgcaacccc gcggtctatc 1621 gccgctactt ccactggcgc cggagctacg ctgtccacat cacctccttc tgggacgagc 1681 cttggtgccg ggtgtgccag gctgtacaga gggctgggga ccggcccaag agcatacgga 1741 acttggccag ctggttcgag cggtgaagcc gcgctcccct ggaagcgacc caggggaggc 1801 caagttgtca gctttttgat cctctactgt gcatctcctt gactgccgca tcatgggagt 1861 aagttcttca aacacccatt tttgctctat gggaaaaaaa cgatttacca attaatatta 1921 ctcagcacag agatgggggc ccggtttcca tattttttgc acagctagca attgggctcc 1981 ctttgctgct gatgggcatc attgtttagg ggtgaaggag ggggttcttc ctcaccttgt 2041 aaccagtgca gaaatgaaat agcttagcgg caagaagccg ttgaggcggt ttcctgaatt 2101 tccccatctg ccacaggcca tatttgtggc ccgtgcagct tccaaatctc atacacaact 2161 gttcccgatt cacgtttttc tggaccaagg tgaagcaaat ttgtggttgt agaaggagcc 2221 ttgttggtgg agagtggaag gactgtggct gcaggtggga ctttgttgtt tggattcctc 2281 acagccttgg ctcctgagaa aggtgaggag ggcagtccaa gaggggccgc tgacttcttt 2341 cacaagtact atctgttccc ctgtcctgtg aatggaagca aagtgctgga ttgtccttgg 2401 aggaaactta agatgaatac atgcgtgtac ctcactttac ataagaaatg tattcctgaa 2461 aagctgcatt taaatcaagt cccaaattca ttgacttagg ggagttcagt atttaatgaa 2521 accctatgga gaatttatcc ctttacaatg tgaatagtca tctcctaatt tgtttcttct 2581 gtctttatgt ttttctataa cctggattt ttaaatcata ttaaaattac agatgtgaaa WO 00/09525 PCT/US99/17712 EPI-109 959 2641 ataaagcaga agcaaccttt ttccctcttc ccagaaaacc agtctgtgtt tacagacaga 2701 agagaaggaa gccatagtgt cacttccaca caattattta tttcatgtct ttactggacc 2761 tgaaatttaa actgcaatgc cagtcctgca ggagtgctgg cattaccctc tgcagaacag 2821 tgaaaggtat tgcactacat tatggaatca tgcaaaaaaa a 1 acgcgtggcg agcggaggca gcgctgcctg ttcgcgccat gggggcaccg tggggctcgc 61 cgacggcggc ggcgggcggg cggcgcgggt ggcgccgagg ccgggggctg ccatggaccg 121 tctgtgtgct ggcggccgcc ggcttgacgt gtacggcgct gatcacctac gcttgctggg 181 ggcagctgcc gccgctgccc tgggcgtcgc caaccccgtc gcgaccggtg ggcgtgctgc 241 tgtggtggga gcccttcggg gggcgcgata gcgccccgag gccgccccct gactgcccgc 301 tgcgcttcaa catcagcggc tgccgcctgc tcaccgaccg cgcgtcctac ggagaggctc 361 aggccgtgct tttccaccac cgcgacctcg tgaaggggcc ccccgactgg cccccgccct 421 ggggcatcca ggcgcacact gccgaggagg tggatctgcg cgtgttggac tacgaggagg 481 cagcggcggc ggcagaagcc ctggcgacct ccagccccag gcccccgggc cagcgctggg 541 tttggatgaa cttcgagtcg ccctcgcact ccccggggct gcgaagcctg gcaagtaacc 601 tcttcaactg gacgctctcc taccgggcgg actcggacgt ctttgtgcct tatggctacc 661 tctaccccag aagccacccc ggcgacccgc cctcaggcct ggccccgcca ctgtccagga 721 aacaggggct ggtggcatgg gtggtgagcc actgggacga gcgccaggcc cgggtccgct 781 actaccacca actgagccaa catgtgaccg tggacgtgtt cggccggggc gggccggggc 841 agccggtgcc cgaaattggg ctcctgcaca cagtggcccg ctacaagttc tacctggctt 901 tcgagaactc gcagcacctg gattatatca ccgagaagct ctggcgcaac gcgttgctcg 961 ctggggcggt gccggtggtg ctgggcccag accgtgccaa ctacgagcgc tttgtgcccc 1021 gcggcgcctt catccacgtg gacgacttcc caagtgcctc ctccctggcc tcgtacctgc 1081 ttttcctcga ccgcaacccc gcggtctatc gccgctactt ccactggcgc cggagctacg 1141 ctgtccacat cacctccttc tgggacgagc cttggtgccg ggtgtgccag gctgtacaga 1201 gggctgggga ccggcccaag agcatacgga acttggccag ctggttcgag cggtag 1 cagatactct gacccatgga tcccctgggc ccggccaagc cacagtggtc gtggcgctgc 61 tgtctgacca cgctgctgtt tcagctgctg atggctgtgt gtttcttctc ctatctgcgt 121 gtgtctcaag acgatcccac tgtgtaccct aatgggtccc gcttcccaga cagcacaggg 181 acccccgccc actccatccc cctgatcctg ctgtggacgt ggccttttaa caaacccata 241 gctctgcccc gctgctcaga gatggtgcct ggcacggctg actgcaacat cactgccgac 301 cgcaaggtgt atccacaggc agacgcggtc atcgtgcacc accgagaggt catgtacaac 361 cccagtgccc agctcccacg ctccccgagg cggcaggggc agcgatggat ctggttcagc 421 atggagtccc caagccactg ctggcagctg aaagccatgg acggatactt caatctcacc 481 atgtcctacc gcagcgactc cgacatcttc acgccctacg gctggctgga gccgtggtcc 541 ggccagcctg cccacccacc gctcaacctc tcggccaaga ccgagctggt ggcctgggca 601 gtgtccaact gggggccaaa ctccgccagg gtgcgctact accagagcct gcaggcccat 661 ctcaaggtgg acgtgtacgg acgctcccac aagcccctgc cccagggaac catgatggag 721 acgctgtccc ggtacaagtt ctatctggcc ttcgagaact ccttgcaccc cgactacatc 781 accgagaagc tgtggaggaa cgccctggag gcctgggccg tgcccgtggt gctgggcccc 841 agcagaagca actacgagag gttcctgccg cccgacgcct tcatccacgt ggacgacttc 901 cagagcccca aggacctggc ccggtacctg caggagctgg acaaggacca cgcccgctac 961 ctgagctact ttcgctggcg ggagacgctg cggcctcgct ccttcagctg ggcactcgct 1021 ttctgcaagg cctgctggaa actgcaggag gaatccaggt accagacacg cggcatagcg 1081 gcttggttca cctgagaggc ccggcatggg gcctgggctg ccaggg 1 aaggagcaca gttccaggcg gggctgagct agggcgtagc tgtgatttca ggggcacctc 61 tggcggctgc cgtgatttga gaatctcggg tctcttggct gactgatcct gggagactgt 121 ggatgaataa tgctgggcac ggccccaccc ggaggctgcg aggcttgggg gtcctggccg 181 gggtggctct gctcgctgcc ctctggctcc tgtggctgct ggggtcagcc cctcggggta 241 ccccggcacc ccagcccacg atcaccatcc ttgtctggca ctggcccttc actgaccagc 301 ccccagagct gcccagcgac acctgcaccc gctacggcat cgcccgctgc cacctgagtg 361 ccaaccgaag cctgctggcc agcgccgacg ccgtggtctt ccaccaccgc gagctgcaga 421 cccggcggtc ccacctgccc ctggcccagc ggccgcgagg gcagccctgg gtgtgggcct 481 ccatggagtc tcctagccac acccacggcc tcagccacct ccgaggcatc ttcaactggg 541 tgctgagcta ccggcgcgac tcggacatct ttgtgcccta tggccgcctg gagccccact 601 gggggccctc gccaccgctg ccagccaaga gcagggtggc cgcctgggtg gtcagcaact 661 tccaggagcg gcagctgcgt gccaggctgt accggcagct ggcgcctcat ctgcgggtgg 721 atgtctttgg ccgtgccaat ggacggccac tgtgcgccag ctgcctggtg cccaccgtgg 781 cccagtaccg cttctacctg tcctttgaga actctcagca ccgcgactac attacggaga 841 aattctggcg caacgcactg gtggctggca ctgtgccagt ggtgctgggg cccccacggg 901 ccacctatga ggccttcgtg ccggctgacg ccttcgtgca tgtggatgac tttggctcag 961 cccgagagct ggcggctttc ctcactggca tgaatgagag ccgataccaa cgcttctttg 1021 cctggcgtga caggctccgc gtgcgactgt tcaccgactg gcgggaacgt ttctgtgcca 1081 tctgtgaccg ctacccacac ctaccccgca gccaagtcta tgaggacctt gagggttggt 1141 ttcaggcctg agatccgctg gccgggggag gtgggtgtgg gtggaagggc tgggtgtcga 1201 aatcaaacca ccaggcatcc ggcccttacc ggcaagcagc gggctaacgg gaggctgggc 1261 acagaggtca ggaagcaggg gtggggggtg caggtgggca ctggagcatg cagaggaggt 1321 gagagtggga gggaggtaac gggtgcctgc tgcggcagac gggaggggaa aggctgccga 1381 ggaccctccc caccctgaac aaatcttggg tgggtgaagg cctggctgga agagggtgaa WO 00/09525 PCT/US99/17712 EPI-109 960 1441 aggcagggcc cttggggctg gggggcaccc cagcctgaag tttgtggggg ccaaacctgg 1501 gaccccgagc ttcctcggta gcagaggccc tgtggtcccc gagacacagg cacgggtccc 1561 tgccacgtcc atagttctga ggtccctgtg tgtaggctgg ggcggggccc aggagaccac 1621 ggggagcaaa ccagcttgtt ctgggctcag ggagggaggg cggtggacaa taaacgtctg 1681 agcagtgaaa aaaaaaaaaa a (2) INFORMATION FOR SEQ ID NO:2705: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2705 1 cccccctcca agataatttt taaaaaacct tctcctttgc tcacctttgc ttcccagcct 61 tcccatcccc ccaccgaaag caaatcattc aacgaccccc gaccctccga cggcaggagc 121 cccccgacct cccaggcgga ccgccctccc tccccggggt tccgggcccg gcgagagggc 181 gcgagcacag ccgaggccat ggaggtgacg gcggaccagc cgcgctgggt gagccaccac 241 caccccgccg tgctcaacgg gcagcacccg gacacgcacc acccgggcct cagccactcc 301 tacatggacg cggcgcagta cccgctgccg gaggaggtgg atgtgctttt taacatcgac 361 ggtcaaggca accacgtccc gccctactac ggaaactcgg tcagggccac ggtgcagagg 421 taccctccga cccaccacgg gagccaggtg tgccgcccgc ctctgcttca tggatcccta 481 ccctggctgg acggcggcaa agccctgggc agccaccaca ccgcctcccc ctggaatctc 541 agccccttct ccaagacgtc catccaccac ggctccccgg ggcccctctc cgtctacccc 601 ccggcctcgt cctcctcctt gtcggggggc cacgccagcc cgcacctctt caccttcccg 661 cccaccccgc cgaaggacgc ctccccggac ccatcgctgt ccaccccagg ctcggccggc 721 tcggcccggc aggacgagaa agagtgcctc aagtaccagg tgcccctgcc cgacagcatg 781 aagctggagt cgtcccactc ccgtggcagc atgaccgccc tgggtggagc ctcctcgtcg 841 acccaccacc ccatcaccac ctacccgccc tacgtgcccg agtacagctc cggactcttc 901 ccccccagca gcctgctggg cggctccccc accggcttcg gatgcaagtc caggcccaag 961 gcccggtcca gcacagaagg cagggagtgt gtgaactgtg gggcaacctc gaccccactg 1021 tggcggcgag atggcacggg acactacctg tgcaacgcct gcgggctcta tcacaaaatg 1081 aacggacaga accggcccct cattaagccc aagcgaaggc tgtctgcagc caggagagca 1141 gggacgtcct gtgcgaactg tcagaccacc acaaccacac tctggaggag gaatgccaat 1201 ggggaccctg tctgcaatgc ctgtgggctc tactacaagc ttcacaatat taacagaccc 1261 ctgactatga agaaggaagg catccagacc agaaaccgaa aaatgtctag caaatccaaa 1321 aagtgcaaaa aagtgcatga ctcactggag gacttcccca agaacagctc gtttaacccg 1381 gccgccctct ccagacacat gtcctccctg agccacatct cgcccttcag ccactccagc 1441 cacatgctga ccacgcccac gccgatgcac ccgccatcca gcctgtcctt tggaccacac 1501 cacccctcca gcatggtcac cgccatgggt tagagccctg ctcgatgctc acagggcccc 1561 cagcgagagt ccctgcagtc cctttcgact tgcatttttg caggagcagt atcatgaagc 1621 ctaaacgcga tggatatatg tttttgaagg cagaaagcaa aattatgttt gccactttgc 1681 aaaggagctc actgtggtgt ctgtgttcca accactgaat ctggacccca tctgtgaata 1741 agccattctg actcatatcc cctatttaac agggtctcta gtgctgtgaa aaaaaaaatg 1801 ctgaacattg catataactt atattgtaag aaatactgta caatgacttt attgcatctg 1861 ggtagctgta aggcatgaag gatgccaaga agtttaagga atatgggaga aatggtgtgg 1921 aaattaagaa gaaactaggt ctgatattca aatggacaaa ctgccagttt tgtttccttt 1981 cactggccac agttgtttga tgcattaaaa gaaaataaaa aaaag (2) INFORMATION FOR SEQ ID NO:2706: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: _base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2706 1 acacagagag aaaggctaaa gttctctgga ggatgtggct gcagagcctg ctgctcttgg 61 gcactgtggc ctgcagcatc tctgcacccg cccgctcgcc cagccccagc acgcagccct 121 gggagcatgt gaatgccatc caggaggccc ggcgtctcct gaacctgagt agagacactg 181 ctgctgagat gaatgaaaca gtagaagtca tctcagaaat gtttgacctc caggagccga 241 cctgcctaca gacccgcctg gagctgtaca agcagggcct gcggggcagc ctcaccaagc 301.tcaagggccc cttgaccatg atggccagcc actacaagca gcactgccct ccaaccccgg 361 aaacttcctg tgcaacccag attatcacct ttgaaagttt caaagagaac ctgaaggact 421 ttctgcttgt catccccttt gactgctggg agccagtcca ggagtgagac cggccagatg 481 aggctggcca agccggggag ctgctctctc atgaaacaag agctagaaac tcaggatggt 541 catcttggag ggaccaaggg gtgggccaca gccatggtgg gagtggcctg gacctgccct 601 gggcacactg accctgatac aggcatggca gaagaatggg aatattttat actgacagaa 661 atcagtaata tttatatatt tatattttta aaatatttat ttatttattt atttaagttc 721 atattccata tttattcaag atgttttacc gtaataatta ttattaaaaa tagcttctaa 781 aaaaaaaaa WO 00/09525 PCT/US99/17712 EPI-109 961 (2) INFORMATION FOR SEQ ID NO:2707: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2707 1 ttctctctga ccagcaccat gcttctcctg gtgacaagcc ttctgctctg tgagttacca 61 cacccagcat tcctcctgat cccagagaaa tcggatctgc gaacagtggc accagcctct 121 agtctcaatg tgaggtttga ctccaggacg atgaatttaa gctgggactg ccaagaaaac 181 acaaccttca gcaagtgttt cttaactgac aagaagaaca gagtcgtgga acccaggctc 241 agtaacaacg aatgttcgtg cacatttcgt gaaatttgtc tgcatgaagg agtcacattt 301 gaggttcacg tgaatactag tcaaagagga tttcaacaga aactgcttta tccaaattca 361 ggaagggagg gtaccgctgc tcagaatttc tcctgtttca tctacaatgc ggatttaatg 421 aactgtacct gggcgagggg tccgacggcc ccccgtgacg tccagtattt tttgtacata 481 cgaaactcaa agagaaggag ggagatccgg tgtccttatt acatacaaga ctcaggaacc 541 catgtgggat gtcacctgga taacctgtca ggattaacgt ctcgcaatta ctttctggtt 601 aacggaacca gccgagaaat tggcatccaa ttctttgatt cacttttgga cacaaagaaa 661 atagaacgat tcaaccctcc cagcaatgtc accgtacgtt gcaacacgac gcactgcctc 721 gtacggtgga aacagcccag gacctatcag aagctgtcgt acctggactt tcagtaccag 781 ctggacgtcc acagaaagaa tacccagcct ggcacggaaa acctactgat taatgtttct 841 ggtgatttgg aaaatagata caactttcca agctctgagc ccagagcaaa acacagtgtg 901 aagatcagag ctgcagacgt ccgcatcttg aattggagct cctggagtga agccattgaa 961 tttggttcct taggatacag cggctgttcc cgccagttcc acagatcaaa gacaaactga 1021 atgataacca tgaggtggaa gacgagatca tctgggagga attcacccca gaggaaggga 1081 aaggctaccg cgaagaggtc ttgaccgtga aggaaattac ctgagaccca gagggtgtag 1141 gaatggcatg gacatctccg cctccgcgac acgggggaac tgttttcttg atgatgctgt 1201 gaacctttat atcattttct atgtttttat ttaaaaacat gacatttggg gccaggcgcg 1261 gtggctcacg cctgtaatcc cag (2) INFORMATION FOR SEQ ID NO:2708 (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: _base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2708 1 ttctcagagt ggctgcagtc tcgctgctgg atgtgcacat ggtggtcatt ccctctgctc 61 acaggggcag gggtcccccc ttactggact gaggttgccc cctgctccag gtcctgggtg 121 ggagcccatg tgaactgtca gtggggcagg tctgtgagag ctcccctcac actcaagtct 181 ctctcacagt ggccagagaa gaggaaggct ggagtcagaa tgaggcacca gggcgggcat 241 agcctgccca aaggcccctg ggattacagg caggatgggg agccctatct aagtgtctcc 301 cacgccccac cccagccatt ccaggccagg aagtccaaac tgtgcccctc agagggaggg 361 ggcagcctca ggcccattca gactgcccag ggagggctgg agagccctca ggaaggcggg 421 tgggtgggct gtcggttctt ggaaaggttc attaatgaaa acccccaagc ctgaccacct 481 agggaaaagg ctcaccgttc ccatgtgtgg ctgataaggg ccaggagatt ccacagttca 541 ggtagttccc ccgcctccct ggcattttgt ggtcaccatt aatcatttcc tctgtgtatt 601 taagagctct tttgccagtg agcccagcta cacagagaga aaggctaaag ttctctggag 661 gatgtggctg cagagcctgc tgctcttggg cactgtggcc tgcagcatct ctgcacccgc 721 ccgctcgccc agccccagca cgcagccctg ggagcatgtg aatgccatcc aggaggcccg 781 gcgtctcctg aacctgagta gagacactgc tgctgagatg gtaagtgaga gaatgtgggc 841 ctgtgctagg caccagtggc cctgactggc cacgcctgtc agcttgataa catgacattt 901 tccttttcta cagaatgaaa cagtagaagt catctcagaa atgtttgacc tccaggtaag 961 atgcttctct ctgacatagc tttccagaag cccctgccct ggggtggagg tggggactcc 1021 attttagatg gcaccacaca gggttgtcca ctttctctcc agtcagctgg ctgcaggagg 1081 agggggtagc aactgggtgc tcaagaggct gctggccgtg cccctatggc agtcacatga 1141 gctcctttat cagctgagcg gccatgggca gacctagcat tcaatggcca ggagtcacca 1201 ggggacaggt ggtaaagtgg gggtcacttc atgagacagg agctgtgggt ttggggcgct 1261 cactgtgccc cgagaccaag tcctgttgag acagtgctga ctacagagag gcacagaggg 1321 gtttcaggaa caacccttgc ccacccagca ggtccaggtg aggccccacc cccctctccc 1381 tgaatgatgg ggtgagagtc acctccttcc ctaaggctgg gctcctctcc aggtgccgct 1441 gagggtggcc tgggcggggc agtgagaagg gcaggttcgt gcctgccatg gacagggcag 1501 ggtctatgac tggacccagc ctgtgcccct cccaagccct actcctgggg gctgggggca 1561 gcagcaaaaa ggagtggtgg agagttcttg taccactgtg ggcacttggc cactgctcac 1621 cgacgaacga cattttccac aggagccgac ctgcctacag acccgcctgg agctgtacaa 1681 gcagggcctg cggggcagcc tcaccaagct caagggcccc ttgaccatga tggccagcca 1741 ctacaagcag cactgccctc caaccccggt gagtgcctac ggcagggcct ccagcaggaa 1801 tgtcttaatc tagggggtgg ggtcgacatg gggagagatc tatggctgtg gctgttcagg WO 00/09525 PCT/US99/17712 EPI-109 962 1861 accccagggg gtttctgtgc caacagttat gtaatgatta gccctccaga gaggaggcag 1921 acagcccatt tcatcccaag gagtcagagc cacagagcgc tgaagcccac agtgctcccc 1981 agcaggagct gctcctatcc tggtcattat tgtcattacg gttaatgagg tcagaggtga 2041 gggcaaaccc aaggaaactt ggggcctgcc caaggcccag aggaagtgcc caggcccaag 2101 tgccaccttc tggcaggact ttcctctggc cccacatggg gtgcttgaat tgcagaggat 2161 caaggaaggg aggctacttg gaatggacaa ggacctcagg cactccttcc tgcgggaagg 2221 gagcaaagtt tgtggccttg actccactcc ttctgggtgc ccagagacga cctcagccca 2281 gctgccctgc tctgccctgg gaccaaaaag gcaggcgttt gactgcccag aaggccaacc 2341 tcaggctggc acttaagtca ggcccttgac tctggctgcc actggcagag ctatgcactc 2401 cttggggaac acgtgggtgg cagcagcgtc acctgaccca ggtcagtggg tgtgtcctgg 2461 agtgggcctc ctggcctctg agttctaaga ggcagtagag aaacatgctg gtgcttcctt 2521 cccccacgtt acccacttgc ctggactcaa gtgtttttta tttttctttt tttaaaggaa 2581 acttcctgtg caacccagat tatcaccttt gaaagtttca aagagaacct gaaggacttt 2641 ctgcttgtca tcccctttga ctgctgggag ccagtccagg agtgagaccg gccagatgag 2701 gctggccaag ccggggagct gctctctcat gaaacaagag ctagaaactc aggatggtca 2761 tcttggaggg accaaggggt gggccacagc catggtggga gtggcctgga cctgccctgg 2821 gcacactgac cctgatacag gcatggcaga agaatgggaa tattttatac tgacagaaat 2881 cagtaatatt tatatattta tatttttaaa atatttattt atttatttat ttaagttcat 2941 attccatatt tattcaagat gttttaccgt aataattatt attaaaaata tgcttctact 3001 tgtccagtgt tctagtttgt ttttaaccat gagcaaatgc cat (2) INFORMATION FOR SEQ ID NO:2709: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2709 1 acacagagag aaaggctaaa gttctctgga ggatgtggct gcagagcctg ctgctcttgg 61 gcactgtggc ctgcagcatc tctgcacccg cccgctcgcc cagccccagc acgcagccct 121 gggagcatgt gaatgccatc caggaggccc ggcgtctcct gaacctgagt agagacactg 181 ctgctgagat gaatgaaaca gtagaagtca tctcagaaat gtttgacctc caggagccga 241 cctgcctaca gacccgcctg gagctgtaca agcagggcct gcggggcagc ctcaccaagc 301 tcaagggccc cttgaccatg atggccagcc actacaagca gcactgccct ccaaccccgg 361 aaacttcctg tgcaacccag attatcacct ttgaaagttt caaagagaac ctgaaggact 421 ttctgcttgt catccccttt gactgctggg agccagtcca ggagtgagac cggccagatg 481 aggctggcca agccggggag ctgctctctc atgaaacaag agctagaaac tcaggatggt 541 catcttggag ggaccaaggg gtgggccaca gccatggtgg gagtggcctg gacctgccct 601 gggcacactg accctgatac aggcatggca gaagaatggg aatattttat actgacagaa 661 atcagtaata tttatatatt tatattttta aaatatttat ttatttattt atttaagttc 721 atattccata tttattcaag atgttttacc gtaataatta ttattaaaaa tagcttctaa 781 aaaaaaaaa 1 ttctctctga ccagcaccat gcttctcctg gtgacaagcc ttctgctctg tgagttacca 61 cacccagcat tcctcctgat cccagagaaa tcggatctgc gaacagtggc accagcctct 121 agtctcaatg tgaggtttga ctccaggacg atgaatttaa gctgggactg ccaagaaaac 181 acaaccttca gcaagtgttt cttaactgac aagaagaaca gagtcgtgga acccaggctc 241 agtaacaacg aatgttcgtg cacatttcgt gaaatttgtc tgcatgaagg agtcacattt 301 gaggttcacg tgaatactag tcaaagagga tttcaacaga aactgcttta tccaaattca 361 ggaagggagg gtaccgctgc tcagaatttc tcctgtttca tctacaatgc ggatttaatg 421 aactgtacct gggcgagggg tccgacggcc ccccgtgacg tccagtattt tttgtacata 481 cgaaactcaa agagaaggag ggagatccgg tgtccttatt acatacaaga ctcaggaacc 541 catgtgggat gtcacctgga taacctgtea ggattaacgt ctcgcaatta ctttctggtt 601 aacggaacca gccgagaaat tggcatccaa ttctttgatt cacttttgga cacaaagaaa 661 atagaacgat tcaaccctcc cagcaatgtc accgtacgtt gcaacacgac gcactgcctc 721 gtacggtgga aacagcccag gacctatcag aagctgtcgt acctggactt tcagtaccag 781 ctggacgtcc acagaaagaa tacccagcct ggcacggaaa acctactgat taatgtttct 841 ggtgatttgg aaaatagata caactttcca agctctgagc ccagagcaaa acacagtgtg 901 aagatcagag ctgcagacgt ccgcatcttg aattggagct cctggagtga agccattgaa 961 tttggttcct taggatacag cggctgttcc cgccagttcc acagatcaaa gacaaactga 1021 atgataacca tgaggtggaa gacgagatca tctgggagga attcacccca gaggaaggga 1081 aaggctaccg cgaagaggtc ttgaccgtga aggaaattac ctgagaccca gagggtgtag 1141 gaatggcatg gacatctccg cctccgcgac acgggggaac tgttttcttg atgatgctgt 1201 gaacctttat atcattttct atgtttttat ttaaaaacat gacatttggg gccaggcgcg 1261 gtggctcacg cctgtaatcc cag 1 ttctcagagt ggctgcagtc tcgctgctgg atgtgcacat ggtggtcatt ccctctgctc 61 acaggggcag gggtcccccc ttactggact gaggttgccc cctgctccag gtcctgggtg 121 ggagcccatg tgaactgtca gtggggcagg tctgtgagag ctcccctcac actcaagtct 181 ctctcacagt ggccagagaa gaggaaggct ggagtcagaa tgaggcacca gggcgggcat 241 agcctgccca aaggcccctg ggattacagg caggatgggg agccctatct aagtgtctcc WO 00/09525 PCT/US99/17712 EPI-109 963 301 cacgccccac cccagccatt ccaggccagg aagtccaaac tgtgcccctc agagggaggg 361 ggcagcctca ggcccattca gactgcccag ggagggctgg agagccctca ggaaggcggg 421 tgggtgggct gtcggttctt ggaaaggttc attaatgaaa acccccaagc ctgaccacct 481 agggaaaagg ctcaccgttc ccatgtgtgg ctgataaggg ccaggagatt ccacagttca 541 ggtagttccc ccgcctccct ggcattttgt ggtcaccatt aatcatttcc tctgtgtatt 601 taagagctct tttgccagtg agcccagcta cacagagaga aaggctaaag ttctctggag 661 gatgtggctg cagagcctgc tgctcttggg cactgtggcc tgcagcatct ctgcacccgc 721 ccgctcgccc agccccagca cgcagccctg ggagcatgtg aatgccatcc aggaggcccg 781 gcgtctcctg aacctgagta gagacactgc tgctgagatg gtaagtgaga gaatgtgggc 841 ctgtgctagg caccagtggc cctgactggc cacgcctgtc agcttgataa catgacattt 901 tccttttcta cagaatgaaa cagtagaagt catctcagaa atgtttgacc tccaggtaag 961 atgcttctct ctgacatagc tttccagaag cccctgccct ggggtggagg tggggactcc 1021 attttagatg gcaccacaca gggttgtcca ctttctctcc agtcagctgg ctgcaggagg 1081 agggggtagc aactgggtgc tcaagaggct gctggccgtg cccctatggc agtcacatga 1141 gctcctttat cagctgagcg gccatgggca gacctagcat tcaatggcca ggagtcacca 1201 ggggacaggt ggtaaagtgg gggtcacttc atgagacagg agctgtgggt ttggggcgct 1261 cactgtgccc cgagaccaag tcctgttgag acagtgctga ctacagagag gcacagaggg 1321 gtttcaggaa caacccttgc ccacccagca ggtccaggtg aggccccacc cccctctccc 1381 tgaatgatgg ggtgagagtc acctccttcc ctaaggctgg gctcctctcc aggtgccgct 1441 gagggtggcc tgggcggggc agtgagaagg gcaggttcgt gcctgccatg gacagggcag 1501 ggtctatgac tggacccagc ctgtgcccct cccaagccct actcctgggg gctgggggca 1561 gcagcaaaaa ggagtggtgg agagttcttg taccactgtg ggcacttggc cactgctcac 1621 cgacgaacga cattttccac aggagccgac ctgcctacag acccgcctgg agctgtacaa 1681 gcagggcctg cggggcagcc tcaccaagct caagggcccc ttgaccatga tggccagcca 1741 ctacaagcag cactgccctc caaccccggt gagtgcctac ggcagggcct ccagcaggaa 1801 tgtcttaatc tagggggtgg ggtcgacatg gggagagatc tatggctgtg gctgttcagg 1861 accccagggg gtttctgtgc caacagttat gtaatgatta gccctccaga gaggaggcag 1921 acagcccatt tcatcccaag gagtcagagc cacagagcgc tgaagcccac agtgctcccc 1981 agcaggagct gctcctatcc tggtcattat tgtcattacg gttaatgagg tcagaggtga 2041 gggcaaaccc aaggaaactt ggggcctgcc caaggcccag aggaagtgcc caggcccaag 2101 tgccaccttc tggcaggact ttcctctggc cccacatggg gtgcttgaat tgcagaggat 2161 caaggaaggg aggctacttg gaatggacaa ggacctcagg cactccttcc tgcgggaagg 2221 gagcaaagtt tgtggccttg actccactcc ttctgggtgc ccagagacga cctcagccca 2281 gctgccctgc tctgccctgg gaccaaaaag gcaggcgttt gactgcccag aaggccaacc 2341 tcaggctggc acttaagtca ggcccttgac tctggctgcc actggcagag ctatgcactc 2401 cttggggaac acgtgggtgg cagcagcgtc acctgaccca ggtcagtggg tgtgtcctgg 2461 agtgggcctc ctggcctctg agttctaaga ggcagtagag aaacatgctg gtgcttcctt 2521 cccccacgtt acccacttgc ctggactcaa gtgtttttta tttttctttt tttaaaggaa 2581 acttcctgtg caacccagat tatcaccttt gaaagtttca aagagaacct gaaggacttt 2641 ctgcttgtca tcccctttga ctgctgggag ccagtccagg agtgagaccg gccagatgag 2701 gctggccaag ccggggagct gctctctcat gaaacaagag ctagaaactc aggatggtca 2761 tcttggaggg accaaggggt gggccacagc catggtggga gtggcctgga cctgccctgg 2821 gcacactgac cctgatacag gcatggcaga agaatgggaa tattttatac tgacagaaat 2881 cagtaatatt tatatattta tatttttaaa atatttattt atttatttat ttaagttcat 2941 attccatatt tattcaagat gttttaccgt aataattatt attaaaaata tgcttctact 3001 tgtccagtgt tctagtttgt ttttaaccat gagcaaatgc cat (2) INFORMATION FOR SEQ ID NO:2710: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: _base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2710 1 atcctggctg atatggtgaa accccatctc tactaaaaat acaaaaatta gctgggcgtg 61 gtggtgggcg catgtaatcc cagctactca ggaggctgag gcaggagaat tacttgaacc 121 tgggaggcag aggttgcagt gaaccgagat cgcgccattg cactccagtc tggcgacaga 181 gcgagactcc gtctctaaact aaataaataa ataaatttag ccttctactc aagaacttat 241 ctggctttgt cttaatgtaa aaataatttc tttttgctaa attattgaga gaaatttact 301 atttattagt gtttatcagt tttctttaaa ctcaccactt tttgatgaat atgaaaatct 361 aaaaacttgg ccgggcgcag tggctcacac ctgtaatctc agcactttgg gaggccaagg 421 tgggcggatc atctgaggtc aggagttcaa gatcagcctg accaacatgg tgaaacccct 481 tctctactaa aaatacaaaa attagctggg cgtggtggtg ggtgcctgta attgtagcta 541 cttgggaggc tgaggcatga gaatcacttg aacccagaaa gcagaggttg cagtgagctg 601 agatggtgcc actgcactcc agcctgggtg acagagtgag actctgtcct aaaaaaaaaa 661 aaaaaaaaaa tggctgggcg tggtgcctca tgcctgtaat cccagcactt tgggagtcca 721 gcgtgggtgg atcaccgag gtcaggagtt caagtccagc ctgaccaaca tggtgaaacc 781 ccgtctctac taaaaaagta caaaaaaaat agccgggtgc ggtggcacac tcctgtaatc 841 ccagctactc aggaggctga ggcaggagaa tcactgaat ttgggagctg gagattgtag WO 00/09525 PCT/US99/17712 EPI-109 964 901 tcagccaaga tggtgccatt gcactccagt ctgggtgaca gagtgagact ccatctcaaa 961 aaaaaaaaaa aaatcttaaa aactccttcc agaagattta atacttactt tcacccaacc 1021 acccgacttg agtatcacca ataacagagg atacagtccg ttttcagtag agccttagta 1081 gcaaagggtt ttcattttta tttttcagat acaggatctt gccctgtcac ccaagctgga 1141 gtgcagtgat gtgatcatag ctgactgcag cctcctgagt agctaggact ataggtgtat 1201 tataggacaa tttttaaaaa atttcattgt aaagacagga ttccactgtg ttgcccaggc 1261 tgcaagtctt ggcctcaagt gatcattcca cctttaactc ttgccctcaa gcagtcctcc 1321 cacctcagac tcccaaaatg ctgggattat gggtgtgagc caccatttcc agcctactag 1381 caagggtctt gttacatatt acttggcatg atttatgtaa tttaaaaaaa ttgtttgttt 1441 ttcaaataga aaagtaaaat aacgaatatg cttttccaat aacataatcc ccttctcact 1501 tgagaatttt cctctaaaaa gatatgctag atttatttca tgctttatgt gcctctggtg 1561 tgtcccctta taacctcctc catatcattt agggatggtc tcagctgcaa gtaagaactg 1621 ccacaacagg tgatgtaagc ccaaaaaaaa aaaaaaaaaa aaagcaaagc caagcaaaac 1681 aaagcccatt taattatttc ccataataat aagtctggga gaaagaagat tccagagttg 1741 gctcagcagc ttagtgacag caaggcccta ggctggcatt ttcttggcct tcccgatggt 1801 cccaagatga ctctcatggc ctcaaacatc acttcctcac atcctgtcag ggagaaagag 1861 gcaagtgagc aacaacaatt tgtggtgttt ggatcatttg tcagagagga agaacgttcc 1921 taaaaactcc gcctctgctg tttgacatcc tcatcctatt ccttggccat ggtggtatct 1981 catggtcact cctctatctg ccactgtaaa gaggaactgg attgctatat tctgcttaga 2041 cacatgagga tgcagcccac cttcccagaa catgtgcgga attagatttc tacaaacaca 2101 tttgtcttgc ttctgcccaa ctctctcact agaatgcaca ttccataggg gcaaacattt 2161 ttgtctattt tgttcacagc tatattctca acacctagaa gagtgacaga aattcaataa 2221 atagttgtta agtgagcaaa tgaatgcatg aataaggaaa agggtacatg gctattgagt 2281 aggtaaccag cagtgttgat cacccccaac agcatacaac tccagtctga tgaacatcat 2341 gctactaagt ggccactcat cacccaagtc tctgacctta ctttttctct cttttctccc 2401 agggagtgag ccataactgg cggctgctct tgcgccaatg (2) INFORMATION FOR SEQ ID NO:2711: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2711 1 ccaatgagcc tccccaattc ctcctgcctc ttagaagaca agatgtgtga gggcaacaag 61 accactatgg ccagccccca gctgatgccc ctggtggtgg tcctgagcac tatctgcttg 121 gtcacagtag ggctcaacct gctggtgctg tatgccgtac ggagtgagcg gaagctccac 181 actgtgggga acctgtacat cgtcagcctc tcggtggcgg acttgatcgt gggtgccgtc 241 gtcatgccta tgaacatcct ctacctgctc atgtccaagt ggtcactggg ccgtcctctc 301 tgcctctttt ggctttccat ggactatgtg gccagcacag cgtccatttt cagtgtcttc 361 atcctgtgca ttgatcgcta ccgctctgtc cagcagcccc tcaggtacct taagtatcgt 421 accaagaccc gagcctcggc caccattctg ggggcctggt ttctctcttt tctgtgggtt 481 attcccattc taggctggaa tcacttcatg cagcagacct cggtgcgccg agaggacaag 541 tgtgagacag acttctatga tgtcacctgg ttcaaggtca tgactgccat catcaacttc 601 tacctgccca ccttgctcat gctctggttc tatgccaaga tctacaaggc cgtacgacaa 661 cactgccagc accgggagct catcaatagg tccctccctt ccttctcaga aattaagctg 721 aggccagaga accccaaggg ggatgccaag aaaccaggga aggagtctcc ctgggaggtt 781 ctgaaaagga agccaaaaga tgctggtggt ggatctgtct tgaagtcacc atcccaaacc 841 cccaaggaga tgaaatcccc agttgtcttc agccaagagg atgatagaga agtagacaaa 901 ctctactgct ttccacttga tattgtgcac atgcaggctg cggcagaggg gagtagcagg 961 gactatgtag ccgtcaaccg gagccatggc cagctcaaga cagatgagca gggcctgaac 1021 acacatgggg ccagcgagat atcagaggat cagatgttag gtgatagcca atccttctct 1081 cgaacggact cagataccac cacagagaca gcaccaggca aaggcaaatt gaggagtggg 1141 tctaacacag gcctggatta catcaagttt acttggaaga ggctccgctc gcattcaaga 1201 cagtatgtat ctgggttgca catgaaccgc gaaaggaagg ccgccaaaca gttgggtttt 1261 atcatggcag ccttcatcct ctgctggatc ccttatttca tcttcttcat ggtcattgcc 1321 ttctgcaaga actgttgcaa tgaacatttg cacatgttca ccatctggct gggctacatc 1381 aactccacac tgaaccccct catctacccc ttgtgcaatg agaacttcaa gaagacattc 1441 aagagaattc tgcatattcg ctcctaaggg aggctctgag gggatgcaac aaaatgatcc 1501 ttatgatgtc caacaaggaa atagaggacg aaggcctgtg tgttgccagg caggcacctg 1561 ggctttctgg aatccaaacc acagtcttag gggcttggta gtttggaaag ttcttaggca 1621 ccatagaaga acagcagatg gcggtgatca gcag (2) INFORMATION FOR SEQ ID NO:2712: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear WO 00/09525 PCT/LJS99/17712 EPI-109 965 (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2712 1 atgagcctcc ccaattcctc ctgcctctta gaagacaaga tgtgtgaggg caacaagacc 61 actatggcca gcccccagct gatgcccctg gtggtggtcc tgagcactat ctgcttggtc 121 acagtagggc tcaacctgct ggtgctgtat gccgtacgga gtgagcggaa gctccacact 181 gtggggaacc tgtacatcgt cagcctctcg gtggcggact tgatcgltggg tgccgtcgtc 241 atgcctatga acatcctcta cctgctcatg tccaagtggt cactgggccg tcctctctgc 301 ctcttttggc tttccatgga ctatgtggcc agcacagcgt ccattttcag tgtcttCatc 361 ctgtgcattg atcgctaccg ctctgtccag cagcccctca ggtaccrtaa gtatcgtacc 421 aagacccgag cctcggccac cattctgggg gcctggtttc tctcttt tct gtgggttatt 481 cccattctag gctggaatca cttcatgcag cagacctcgg tgcgccg-aga ggacaagtgt 541 gagacagact tctatgatgt cacctggttc aaggtcatga ctgccatcat caacttctac 601 ctgcccacct tgctcatgct ctggttctat gccaagatct acaaggccgt acgacaacac 661 tgccagcacc gggagctcat caataggtcc ctcccttcct tctcagaaat taagctgagg 721 ccagagaacc ccaaggggga tgccaagaaa ccagggaagg agtctccctg ggaggttctg 781 aaaaggaagc caaaagatgc tggtggtgga tctgtcttga agtcaccatc ccaaaccccc 841 aaggagatga aatccccagt tgtcttcagc caagaggatg atagagaagt agacaaactc 901 tactgctttc cacttgatat tgtgcacatg caggctgcgg cagaggggag tagcagggac 961 tatgtagccg tcaaccggag ccatggccag ctcaagacag atgagcaggg cctgaacaca 1021 catggggcca gcgagatatc agaggatcag atgttaggtg atagccaatc cttctctcga 1081 acggactcag ataccaccac agagacagca ccaggcaaag gcaaattgag gagtgggtct 1141 aacacaggcc tggattacat caagtttact tggaagaggc tccgctcgca ttcaagacag 1201 tatgtatctg ggttgcacat gaaccgcgaa aggaaggccg ccaaacagtt gggttttatc 1261 atggcagcct tcatcctctg ctggatccct tatttcatct tcttcatggt cattgccttc 1321 tgcaagaact gttgcaatg a acatttgcac atgttcacca tctggctggg ctacatcaac 1381 tccacactga accccctcat ctaccccttg tgcaatgaga acttcaagaa gacattcaag 1441 agaattctgc atattcgctc ctaagggagg ctctgagggg atgcaacaaa atgatcctta 1501 tgatgtccaa caaggaaata gaggacgaag gcctgtgtgt tgccaggcag gcacctgggc 1561 tttctggaat ccaaaccaca gtcttagggg cttggtagtt tggaaagttc ttaggcacca 1621 tagaagaaca gcagatggcg gtgatcagca gagagattga actttgagga ggaagcagaa 1681 tctttgcaag aaagtcagac ctgtttcttg taactgggtt caaaaagaaa aaaaaaaaaa 1741 aa (2) INFORMATION FOR SEQ ID NO:2713: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: _base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2713 1 atcctggctg atatggtgaa accccatctc tactaaaaat acaaaaatta gctgggcgtg 61 gtggtgggcg catgtaatcc cagctactca ggaggctgag gcaggagaat tacttgaacc 121 tgggaggcag aggttgcagt gaaccgagat cgcgccattg cactccagtc tggcgacaga 181 gcgagactcc gtctctaaat aaataaataa ataaatttag ccttctactc aagaacttat 241 ctggctttgt cttaatgtaa aaataatttc tttttgctaa attattgaga gaaatttact 301 atttattagt gtttatcagt tttctttaaa ctcaccactt tttgatgaat atgaaaatct 361 aaaaacttgg ccgggcgcag tggctcacac ctgtaatctc agcactztgg gaggccaagg 421 tgggcggatc atctgaggtc aggagttcaa gatcagcctg accaacatgg tgaaacccct 481 tctctactaa aaatacaaaa attagctggg cgtggtggtg ggtgcctgta attgtagcta 541 cttgggaggc tgaggcatga gaatcacttg aacccagaaa gcagaggttg cagtgagctg 601 agatggtgcc actgcactcc agcctgggtg acagagtgag actctgtcct aaaaaaaaaa 661 aaaaaaaaaa tggctgggcg tggtgcctca tgcctgtaat cccagcactt tgggagtcca 721 gcgtgggtgg atcacctgag gtcaggagtt caagtccagc ctgaccaaca tggtgaaacc 781 ccgtctctac taaaaaagta caaaaaaaat agccgggtgt ggtggcacac tcctgtaatc 841 ccagctactc aggaggctga ggcaggagaa tcacttgaat ttgggagctg gagattgtag 901 tcagccaaga tggtgccatt gcactccagt ctgggtgaca gagtgagact ccatctcaaa 961 aaaaaaaaaa aaatcttaaa aactccttcc agaagattta atacttactt tcacccaacc 1021 acccgacttg agtatcacca ataacagagg atacagtccg ttttcagtag agccttagta 1081 gcaaagggtt ttcattttta tttttcagat acaggatctt gccctgtcac ccaagctgga 1141 gtgcagtgat gtgatcatag ctgactgcag cctcctgagt agctaggact ataggtgtat 1201 tataggacaa tttttaaaaa atttcattgt aaagacagga ttccactgtg ttgcccaggc 1261 tgcaagtctt ggcctcaagt gatcattcca cctttaactc ttgccczcaa gcagtcctcc 1321 cacctcagac tcccaaaatg ctgggattat gggtgtgagc caccatttcc agcctactag 1381 caagggtctt gttacatatt acttggcatg atttatgtaa tttaaaaaaa ttgtttgttt 1441 ttcaaataga aaagtaaaat aacgaatatg cttttccaat aacataatcc ccttctcact 1501 tgagaatttt cctctaaaaa gatatgctag atttatttca tgctttatgt gcctctggtg 1561 tgtcccctta taacctcctc catatcattt agggatggtc tcagctgcaa gtaagaactg 1621 ccacaacagg tgatgtaagc ccaaaaaaaa aaaaaaaaaa aaagcaaagc caagcaaaac 1681 aaagcccatt taattatttc ccataataat aagtctggga gaaagaagat tccagagttg 1741 gctcagcagc ttagtgacag caaggcccta ggctggcatt ttcttggcct tcccgatggt WO 00/09525 PCT/US99/17712 EPI-109 966 1801 cccaagatga ctctcatggc ctcaaacatc acttcctcac atcctgtcag ggagaaagag 1861 gcaagtgagc aacaacaatt tgtggtgttt ggatcatttg tcagagagga agaacgttcc 1921 taaaaactcc gcctctgctg tttgacatcc tcatcctatt ccttggccat ggtggtatct 1981 catggtcact cctctatctg ccactgtaaa gaggaactgg attgctatat tctgcttaga 2041 cacatgagga tgcagcccac cttcccagaa catgtgcgga attagatttc tacaaacaca 2101 tttgtcttgc ttctgccca'a ctctctcact agaatgcaca ttccataggg gcaaacattt 2161 ttgtctattt tgttcacagc tatattctca acacctagaa gagtgacaga aattcaataa 2221 atagttgtta agtgagcaaa tgaatgcatg aataaggaaa agggtacatg gctattgagt 2281 aggtaaccag cagtgttgat cacccccaac agcatacaac tccagtctga tgaacatcat 2341 gctactaagt ggccactcat cacccaagtc tctgacctta ctttttctct cttttctccc 2401 agggagtgag ccataactgg cggctgctct tgcgccaatg 1 ccaatgagcc tccccaattc ctcctgcctc ttagaagaca agatgtgtga gggcaacaag 61 accactatgg ccagccccca gctgatgccc ctggtggtgg tcctgagcac tatctgcttg 121 gtcacagtag ggctcaacct gctggtgctg tatgccgtac ggagtgagcg gaagctccac 181 actgtgggga acctgtacat cgtcagcctc tcggtggcgg acttgatcgt gggtgccgtc 241 gtcatgccta tgaacatcct ctacctgctc atgtccaagt ggtcactggg ccgtcctctc 301 tgcctctttt ggctttccat ggactatgtg gccagcacag cgtccatttt cagtgtcttc 361 atcctgtgca ttgatcgcta ccgctctgtc cagcagcccc tcaggtacct taagtatcgt 421 accaagaccc gagcctcggc caccattctg ggggcctggt ttctctcttt tctgtgggtt 481 attcccattc taggctggaa tcacttcatg cagcagacct cggtgcgccg agaggacaag 541 tgtgagacag acttctatga tgtcacctgg ttcaaggtca tgactgccat catcaacttc 601 tacctgccca ccttgctcat gctctggttc tatgccaaga tctacaaggc cgtacgacaa 661 cactgccagc accgggagct catcaatagg tccctccctt ccttctcaga aattaagctg 721 aggccagaga accccaaggg ggatgccaag aaaccaggga aggagtctcc ctgggaggtt 781 ctgaaaagga agccaaaaga tgctggtggt ggatctgtct tgaagtcacc atcccaaacc 841 cccaaggaga tgaaatcccc agttgtcttc agccaagagg atgatagaga agtagacaaa 901 ctctactgct ttccacttga tattgtgcac atgcaggctg cggcagaggg gagtagcagg 961 gactatgtag ccgtcaaccg gagccatggc cagctcaaga cagatgagca gggcctgaac 1021 acacatgggg ccagcgagat atcagaggat cagatgttag gtgatagcca atccttctct 1081 cgaacggact cagataccac cacagagaca gcaccaggca aaggcaaatt gaggagtggg 1141 tctaacacag gcctggatta catcaagttt acttggaaga ggctccgctc gcattcaaga 1201 cagtatgtat ctgggttgca catgaaccgc gaaaggaagg ccgccaaaca gttgggtttt 1261 atcatggcag ccttcatcct ctgctggatc ccttatttca tcttcttcat ggtcattgcc 1321 ttctgcaaga actgttgcaa tgaacatttg cacatgttca ccatctggct gggctacatc 1381 aactccacac tgaaccccct catctacccc ttgtgcaatg agaacttcaa gaagacattc 1441 aagagaattc tgcatattcg ctcctaaggg aggctctgag gggatgcaac aaaatgatcc 1501 ttatgatgtc caacaaggaa atagaggacg aaggcctgtg tgttgccagg caggcacctg 1561 ggctttctgg aatccaaacc acagtcttag gggcttggta gtttggaaag ttcttaggca 1621 ccatagaaga acagcagatg gcggtgatca gcag 1 atgagcctcc ccaattcctc ctgcctctta gaagacaaga tgtgtgaggg caacaagacc 61 actatggcca gcccccagct gatgcccctg gtggtggtcc tgagcactat ctgcttggtc 121 acagtagggc tcaacctgct ggtgctgtat gccgtacgga gtgagcggaa gctccacact 181 gtggggaacc tgtacatcgt cagcctctcg gtggcggact tgatcgtggg tgccgtcgtc 241 atgcctatga acatcctcta cctgctcatg tccaagtggt cactgggccg tcctctctgc 301 ctcttttggc tttccatgga ctatgtggcc agcacagcgt ccattttcag tgtcttcatc 361 ctgtgcattg atcgctaccg ctctgtccag cagcccctca ggtaccttaa gtatcgtacc 421 aagacccgag cctcggccac cattctgggg gcctggtttc tctcttttct gtgggttatt 481 cccattctag gctggaatca cttcatgcag cagacctcgg tgcgccgaga ggacaagtgt 541 gagacagact tctatgatgt cacctggttc aaggtcatga ctgccatcat caacttctac 601 ctgcccacct tgctcatgct ctggttctat gccaagatct acaaggccgt acgacaacac 661 tgccagcacc gggagctcat caataggtcc ctcccttcct tctcagaaat taagctgagg 721 ccagagaacc ccaaggggga tgccaagaaa ccagggaagg agtctccctg ggaggttctg 781 aaaaggaagc caaaagatgc tggtggtgga tctgtcttga agtcaccatc ccaaaccccc 841 aaggagatga aatccccagt tgtcttcagc caagaggatg atagagaagt agacaaactc 901 tactgctttc cacttgatat tgtgcacatg caggctgcgg cagaggggag tagcagggac 961 tatgtagccg tcaaccggag ccatggccag ctcaagacag atgagcaggg cctgaacaca 1021 catggggcca gcgagatatc agaggatcag atgttaggtg atagccaatc cttctctcga 1081 acggactcag ataccaccac agagacagca ccaggcaaag gcaaattgag gagtgggtct 1141 aacacaggcc tggattacat caagtttact tggaagaggc tccgctcgca ttcaagacag 1201 tatgtatctg ggttgcacat gaaccgcgaa aggaaggccg ccaaacagtt gggttttatc 1261 atggcagcct tcatcctctg ctggatccct tatttcatct tcttcatggt cattgccttc 1321 tgcaagaact gttgcaatga acatttgcac atgttcacca tctggctggg ctacatcaac 1381 tccacactga accccctcat ctaccccttg tgcaatgaga acttcaagaa gacattcaag 1441 agaattctgc atattcgctc ctaagggagg ctctgagggg atgcaacaaa atgatcctta 1501 tgatgtccaa caaggaaata gaggacgaag gcctgtgtgt tgccaggcag gcacctgggc 1561 tttctggaat ccaaaccaca gtcttagggg cttggtagtt tggaaagttc ttaggcacca 1621 tagaagaaca gcagatggcg gtgatcagca gagagattga actttgagga ggaagcagaa 1681 tctttgcaag aaagtcagac ctgtttcttg taactgggtt caaaaagaaa aaaaaaaaaa WO 00/09525 PCTIUS99/17712 EPI-109 967 1741 aa (2) INFORMATION FOR SEQ ID NO:2714: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2714 1 cacgcgtccg cgagaaggag gactcgcaag cctcggcggc ccggaaccgg cctcggactg 61 tcgacggaac ctgaggccgc ttgccctccc gccccatgga gcggcccccg gggctgcggc 121 cgggcgcggg cgggccctgg gagatgcggg agcggctggg caccggcggc ttcgggaacg 181 tctgtctgta ccagcatcgg gaacttgatc tcaaaatagc aattaagtct tgtcgcctag 241 agctaagtac caaaaacaga gaacgatggt gccatgaaat ccagattatg aagaagttga 301 accatgccaa tgttgtaaag gcctgtgatg ttcctgaaga attgaatatt ttgattcatg 361 atgtgcctct tctagcaatg gaatactgtt ctggaggaga tctccgaaag ctgctcaaca 421 aaccagaaaa ttgttgtgga cttaaagaaa gccagatact ttctttacta agtgatatag 481 ggtctgggat tcgatatttg catgaaaaca aaattataca tcgagatcta aaacctgaaa 541 acatagttct tcaggatgtt ggtggaaaga taatacataa aataattgat ctgggatatg 601 ccaaagatgt tgatcaagga agtctgtgta catcttttgt gggaacactg cagtatctgg 661 ccccagagct ctttgagaat aagccttaca cagccactgt tgattattgg agctttggga 721 ccatggtatt tgaatgtatt gctggatata ggcctttttt gcatcatctg cagccattta 781 cctggcatga gaagattaag aagaaggatc caaagtgtat atttgcatgt gaagagatgt 841 caggagaagt tcggtttagt agccatttac ctcaaccaaa tagcctttgt agtttaatag 901 tagaacccat gqaaaactgg ctacagttga tgttgaattg ggaccctcag cagagaggag 961 gacctgttga ccttactttg aagcagccaa gatgttttgt attaatggat cacattttga 1021 atttgaagat agtacacatc ctaaatatga cttctgcaaa gataatttct tttctgttac 1081 cacctgatga aagtcttcat tcactacagt ctcgtattga gcgtgaaact ggaataaata 1141 ctggttctca agaacttctt tcagagacag gaatttctct ggatcctcgg aaaccagcct 1201 ctcaatgtgt tctagatgga gttagaggct gtgatagcta tatggtttat ttgtttgata 1261 aaagtaaaac tgtatatgaa gggccatttg cttccagaag tttatctgat tgtgtaaatt 1321 atattgtaca ggacagcaaa atacagcttc caattataca gctgcgtaaa gtgtgggctg 1381 aagcagtgca ctatgtgtct ggactaaaag aagactatag caggctcttt cagggacaaa 1441 gggcagcaat gttaagtctt cttagatata atgctaactt aacaaaaatg aagaacactt 1501 tgatctcagc atcacaacaa ctgaaagcta aattggagtt ttttcacaaa agcattcagc 1561 ttgacttgga gagatacagc gagcagatga cgtatgggat atcttcagaa aaaatgctaa 1621 aagcatggaa agaaatggaa gaaaaggcca tccactatgc tgaggttggt gtcattggat 1681 acctggagga tcagattatg tctttgcatg ctgaaatcat ggagctacag aagagcccct 1741 atggaagacg tcagggagac ttgatggaat ctctggaaca gcgtgccatt gatctatata 1801 agcagttaaa acacagacct tcagatcact cctacagtga cagcacagag atggtgaaaa 1861 tcattgtgca cactgtgcag agtcaggacc gtgtgctcaa ggagctgttt ggtcatttga 1921 gcaagttgtt gggctgtaag cagaagatta ttgatctact ccctaaggtg gaagtggccc 1981 tcagtaatat caaagaagct gacaatactg tcatgttcat gcagggaaaa aggcagaaag 2041 aaatatggca tctccttaaa attgcctgta cacagagttc tgcccggtcc cttgtaggat 2101 ccagtctaga aggtgcagta acccctcaga catcagcatg gctgcccccg acttcagcag 2161 aacatgatca ttctctgtca tgtgtggtaa ctcctcaaga tggggagact tcagcacaaa 2221 tgatagaaga aaatttgaac tgccttggcc atttaagcac tattattcat gaggcaaatg 2281 aggaacaggg caatagtatg atgaatcttg attggagttg gttaacagaa tgagttgtca 2341 cttgttcact gtccccaaac ctatggaagt tgttgctata catgttggaa atgtgttttt 2401 cccccatgaa accattcttc agacatcagt caatggaaga aatggctatg aacagaaact 2461 acatttctac tatgatcaga agaacatgat tttacaagta taacagtttt gagtaattca 2521 agcctctaaa cagacaggaa tttagaaaaa gtcaatgtac ttgtttgaat atttgtttta 2581 ataccacagc tatttagaag catcatcacg acacatttgc cttcagtctt ggtaaaacat 2641 tacttattta actgattaaa aataccttct atgtattagt gtcaactttt aacttttggg 2701 cgtaagacaa agtgtagttt tgtatacaga gaagaaaacc tcaagtaata ggcattttaa 2761 gtaaaagtct acctgtgttt ttttctaaaa aggctgctca caagttctat ttcttgaaga 2821 ataaattcta cctccttgtg ttgcactgaa caggttctct tcctggcatc ataaggagtt 2881 ggtgtaatca ttttaaattc cactgaaaat ttaacagtat ccccttctca tcgaagggat 2941 tgtgtatctg tgcttctaat attagttggc tttcataaat catgttgttg tgtgtatatg 3001 tatttaagat gtacatttaa taatatcaaa gagaagatgc ctgttaattt ataatgtatt 3061 tgaaaattac atgttttttc atttgtaaaa atgagtcatt tgtttaaaca atctttcatg 3121 tcttgtcata caaatttata aaggtctgca ctcctttatc tgtaattgta attccaaaat 3181 ccaaaaagct ctgaaaacaa ggtttccata agcttggtga caaaattcat ttgcttgcaa 3241 tctaatctga actgaccttg aatcttttta tcccatttag tgtgaatatt cctttatttt 3301 gctgcttgat gatgagaggg agggctgctg ccacagactg tggtgagggc tggttaatgt 3361 agtatggtat atgcacaaaa ctacttttct aaaatctaaa atttcataat tctgaaacaa 3421 cttgccccaa gggtttcaga gaaaggactg tggacctcta tcatctgcta agtaatttag 3481 aagatattat ttgtcttaaa aaatgtgaaa tgcttttata ttctaatagt ttttcacttt 3541 gtgtattaaa tggtttttaa attaaaaaaa aaaaaaaaa WO 00/09525 PCT/US99/17712 EPI-109 968 (2) INFORMATION FOR SEQ ID NO:2715: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2715 1 gcccgcgtta agattcccgc attttaatgt tttcaggggg gtgtcatagc cccgggtttg 61 gccgccccag ccccgccttc cccgccccgg ggagcccgcc cccttccccg cgtccctgcc 121 gacagagtta gcacgacatc agtatgagct ggtcaccttc cctgacaacg cagacatgtg 181 gggcctggga aatgaaagag cgccttggga cagggggatt tggaaatgtc atccgatggc 241 acaatcagga aacaggtgag cagattgcca tcaagcagtg ccggcaggag ctcagccccc 301 ggaaccgaga gcggtggtgc ctggagatcc agatcatgag aaggctgacc caccccaatg 361 tggtggctgc ccgagatgtc cctgagggga tgcagaactt ggcgcccaat gacctgcccc 421 tgctggccat ggagtactgc caaggaggag atctccggaa gtacctgaac cagtttgaga 481 actgctgtgg tctgcgggaa ggtgccatcc tcaccttgct gagtgacatt gcctctgcgc 541 ttagatacct tcatgaaaac agaatcatcc atcgggatct aaagccagaa aacatcgtcc 601 tgcagcaagg agaacagagg ttaatacaca aaattattga cctaggatat gccaaggagc 661 tggatcaggg cagtctttgc acatcattcg tggggaccct gcagtacctg gccccagagc 721 tactggagca gcagaagtac acagtgaccg tcgactactg gagcttcggc accctggcct 781 ttgagtgcat cacgggcttc cggcccttcc tccccaactg gcagcccgtg cagtggcatt 841 caaaagtgcg gcagaagagt gaggtggaca ttgttgttag cgaagacttg aatggaacgg 901 tgaagttttc aagctcttta ccctacccca ataatcttaa cagtgtcctg gctgagcgac 961 tggagaagtg gctgcaactg atgctgatgt ggcacccccg acagaggggc acggatccca 1021 cgtatgggcc caatggctgc ttcaaggccc tggatgacat cttaaactta aagctggttc 1081 atatcttgaa catggtcacg ggcaccatcc acacctaccc tgtgacagag gatgagagtc 1141 tgcagagctt gaaggccaga atccaacagg acacgggcat cccagaggag gaccaggagc 1201 tgctgcagga agcgggcctg gcgttgatcc ccgataagcc tgccactcag tgtatttcag 1261 acggcaagtt aaatgagggc cacacattgg acatggatct tgtttttctc tttgacaaca 1321 gtaaaatcac ctatgagact cagatctccc cacggcccca acctgaaagt gtcagctgta 1381 tccttcaaga gcccaagagg aatctcgcct tcttccagct gaggaaggtg tggggccagg 1441 tctggcacag catccagacc ctgaaggaag attgcaaccg gctgcagcag ggacagcgag 1501 ccgccatgat gaatctcctc cgaaacaaca gctgcctctc caaaatgaag aattccatgg 1561 cttccatgtc tcagcagctc aaggccaagt tggatttctt caaaaccagc atccagattg 1621 acctggagaa gtacagcgag caaaccgagt ttgggatcac atcagataaa ctgctgctgg 1681 cctggaggga aatggagcag gctgtggagc tctgtgggcg ggagaacgaa gtgaaactcc 1741 tggtagaacg gatgatggct ctgcagaccg acattgtgga cttacagagg agccccatgg 1801 gccggaagca ggggggaacg ctggacgacc tagaggagca agcaagggag ctgtacagga 1861 gactaaggga aaaacctcga gaccagcgaa ctgagggtga cagtcaggaa atggtacggc 1921 tgctgcttca ggcaattcag agcttcgaga agaaagtgcg agtgatctat acgcagctca 1981 gtaaaactgt ggtttgcaag cagaaggcgc tggaactgtt gcccaaggtg gaagaggtgg 2041 tgagcttaat gaatgaggat gagaagactg ttgtccggct gcaggagaag cggcagaagg 2101 agctctggaa tctcctgaag attgcttgta gcaaggtccg tggtcctgtc agtggaagcc 2161 cggatagcat gaatgcctct cgacttagcc agcctgggca gctgatgtct cagccctcca 2221 cggcctccaa cagcttacct gagccagcca agaagagtga agaactggtg gctgaagcac 2281 ataacctctg caccctgcta gaaaatgcca tacaggacac tgtgagggaa caagaccaga 2341 gtttcacggc cctagactgg agctggttac agacggaaga agaagagcac agctgcctgg 2401 agcaggcctc atgatgtggg gggactcgac cccctgacat ggggcagccc atagcaggcc 2461 ttgtgcagtg gggggactcg accccctgac atggggctgc ctggagcagg ccgcgtgacg 2521 tggggctgcc tggccgcggc tctcacatgg tggttcctgc tgcactgatg gcccaggggt 2581 ctctggtatc cagatggagc tctcgcttcc tcagcagctg tgactttcac ccaggaccca 2641 ggacgcagcc ctccgtgggc actgccggcg ccttgtctgc acactggagg tcctccatta 2701 cagaggccca gcgcacatcg ctggccccac aaacgttcag gggtacagcc atggcagctc 2761 cttcctctgc cgtgagaaaa gtgcttggag tacggtttgc cacacacgtg actggacagt 2821 gtccaattca aatctttcag ggcagagtcc gagcagcgct tggtgacagc ctgtcctctc 2881 ctgctctcca aaggccctgc tccctgtcct ctctcacttt acagcttgtg tttcttctgg 2941 attcagcttc tcctaaacag acagtttaat tatagttgcg gcctggcccc atcctcactt 3001 cctcttttta tttcactgct gctaaaattg tgtttttacc tacaaaaaaa aaaaaaaa (2) INFORMATION FOR SEQ ID NO:2716: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: _base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2716 1 ggcacgagca tggcccttgt gatccaggtg gggaaactaa ggcccagaga agtgaggacc 61 ccgcagacta tcaatcccag tctcttcccc tcactccctg tgaagctctc cagcatcatc WO 00/09525 PCT/US99/17712 EPI-109 969 121 gaggtcccat cagcccttgc cctgttggat gaataggcac ctctggaaga gccaactgtg 181 tgagatggtg cagcccagtg gtggcccggc agcagatcag gacgtactgg gcgaagagtc 241 tcctctgggg aagccagcc *a tgctgcacct gccttcagaa cagggcgctc ctgagaccct 301 ccagcgctgc ctggaggaga atcaagagct ccgagatgcc atccggcaga gcaaccagat 361 tctgcgggag cgctgcgagg agcttctgca tttccaagcc agccagaggg aggagaagga 421 gttcctcatg tgcaagttcc aggaggccag gaaactggtg gagagactcg gcctggagaa 481 gctcgatctg aagaggcaga aggagcaggc tctgcgggag gtggagcacc tgaagagatg 541 ccagcagcag atggctgagg acaaggcctc tgtgaaagcc caggtgacgt ccttgctcgg 601 ggagctgcag gagagccaga gtcgcttgga ggctgccact aaggaatgcc aggctctgga 661 gggtcgggcc cgggcggcca gcgagcaggc gcggcagctg gagagtgagc gcgaggcgct 721 gcagcagcag cacagcgtgc aggtggacca gctgcgcatg cagggccaga gcgtggaggc 781 cgcgctccgc atggagcgcc aggccgcctc ggaggagaag aggaaqctgg cccagttgca 841 ggtggcctat caccagctct tccaagaata cgacaaccac atcaagagca gcgtggtggg 901 cagtgagcgg aagcgaggaa tgcagctgga agatctcaaa cagcagctcc agcaggccga 961 ggaggccctg gtggccaaac aggaggtgat cgataagctg aaggaggagg ccgagcagca 1021 caagattgtg atggagaccg ttccggtgct gaaggcccag gcggatatct acaaggcgga 1081 cttccaggct gagaggcagg cccgggagaa gctggccgag aagaaggagc tcctgcagga 1141 gcagctggag cagctgcaga gggagtacag caaactgaag gccagctgtc aggagtcggc 1201 caggatcgag gacatgagga agcggcatgt cgaggtctcc caggccccct tgccccccgc 1261 ccctgcctac ctctcctctc ccctggccct gcccagccag aggaggagcc cccccgagga 1321 gccacctgac ttctgctgtc ccaagtgcca gtatcaggcc cctgatatgg acaccctgca 1381 gatacatgtc atggagtgca ttgagtaggg ccggccagtg caaggccact gcctgcccga 1441 ggacgtgccc gggaccgtgc agtctgcgct ttcctctccc gcctgcctag cccaggatga 1501 agggctgggt ggccacaact gggatgccac ctggagcccc acccaggagc tggccgcggc 1561 accttacgct tcagctgttg atccgctggt cccctctttt ggggtagatg cggccccgat 1621 caggcctgac tcgctgctct ttttgttccc ttctgtctgc tcgaaccact tgcctcgggc 1681 taatccctcc ctcttcctcc acccggcact ggggaagtca agaatggggc ctggggctct 1741 cagggagaac tgcttcccct ggcagagctg ggtggcagct cttcctccca ccggacaccg 1801 acccgcccgc cgctgtgccc tgggagtgct gccctcttac catgcacacg ggtgctctcc 1861 ttttgggctg catgctattc cattttgcag ccagaccgat gtgtatttaa ccagtcacta 1921 ttgatggaca tttgggttgt ttcccatctt tttgttacca taaataatgg catagtaaaa 1981 aaaaaaaaaa aaaa (2) INFORMATION FOR SEQ ID NO:2717: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2717 1 cacgcgtccg cgagaaggag gactcgcaag cctcggcggc ccggaaccgg cctcggactg 61 tcgacggaac ctgaggccgc ttgccctccc gccccatgga gcggcccccg gggctgcggc 121 cgggcgcggg cgggccctgg gagatgcggg agcggctggg caccggcggc ttcgggaacg 181 tctgtctgta ccagcatcgg gaacttgatc tcaaaatagc aattaagtct tgtcgcctag 241 agctaagtac caaaaacaga gaacgatggt gccatgaaat ccagattatg aagaagttga 301 accatgccaa tgttgtaaag gcctgtgatg ttcctgaaga attgaatatt ttgattcatg 361 atgtgcctct tctagcaatg gaatactgtt ctggaggaga tctccgaaag ctgctcaaca 421 aaccagaaaa ttgttgtgga cttaaagaaa gccagatact ttctttacta agtgatatag 481 ggtctgggat tcgatatttg catgaaaaca aaattataca tcgagatcta aaacctgaaa 541 acatagttct tcaggatgtt ggtggaaaga taatacataa aataattgat ctgggatatg 601 ccaaagatgt tgatcaagga agtctgtgta catcttttgt gggaacactg cagtatctgg 661 ccccagagct ctttgagaat aagccttaca cagccactgt tgattattgg agctttggga 721 ccatggtatt tgaatgtatt gctggatata ggcctttttt gcatcatctg cagccattta 781 cctggcatga gaagattaag aagaaggatc caaagtgtat atttgcatgt gaagagatgt 841 caggagaagt tcggtttagt agccatttac ctcaaccaaa tagcctttgt agtttaatag 901 tagaacccat ggaaaactgg ctacagttga tgttgaattg ggaccctcag cagagaggag 961 gacctgttga ccttactttg aagcagccaa gatgttttgt attaatggat cacattttga 1021 atttgaagat agtacacatc ctaaatatga cttctgcaaa gataatttct tttctgttac 1081 cacctgatga aagtcttcat tcactacagt ctcgtattga gcgtgaaact ggaataaata 1141 ctggttctca agaacttctt tcagagacag gaatttctct ggatcctcgg aaaccagcct 1201 ctcaatgtgt tctagatgga gttagaggct gtgatagcta catggtttat ttgtttgata 1261 aaagtaaaac tgtatatgaa gggccatttg cttccagaag tttatctgat tgtgtaaatt 1321 atattgtaca ggacagcaaa atacagcttc caattataca gctgcgtaaa gtgtgggctg 1381 aagcagtgca ctatgtqtct ggactaaaag aagactatag caggctcttt cagggacaaa 1441 gggcagcaat gttaagtctt cttagatata atgctaactt aacaaaaatg aagaacactt 1501 tgatctcagc atcacaacaa ctgaaagcta aattggagtt ttttcacaaa agcattcagc 1561 ttgacttgga gagatacagc gagcagatga cgtatgggat atcttcagaa aaaatgctaa 1621 aagcatggaa agaaatggaa gaaaaggcca tccactatgc tgaggttggt gtcattggat WO 00/09525 PCT/US99/17712 EPI-109 970 1681 acctggagga tcagattata tctttgcatg ctgaaatcat ggagctacag aagagcccct 1741 atggaagacg tcagggagac ttgatggaat ctctggaaca gcgtgccatt gatctatata 1801 agcagttaaa acacagacct tcagatcact cctacagtga cagcacagag atggtgaaaa 1861 tcattgtgca cactgtgcag agtcaggacc gtgtgctcaa ggagctgttt ggtcatttga 1921 gcaagttgtt gggctgtaag cagaagatta ttgatctact ccctaaggtg gaagtggccc 1981 tcagtaatat caaagaagct gacaatactg tcatgttcat gcagggaaaa aggcagaaag 2041 aaatatggca tctccttaaa attgcctgta cacagagttc tgcccggtcc cttgtaggat 2101 ccagtctaga aggtgcagta acccctcaga catcagcatg gctgcccccg acttcagcag 2161 aacatgatca ttctctgtca tgtgtggtaa ctcctcaaga tggggagact tcagcacaaa 2221 tgatagaaga aaatttgaac tgccttggcc atttaagcac tattattoat gaggcaaatg 2281 aggaacaggg caatagtatg atgaatcttg attggagttg gttaacagaa tgagttgtca 2341 cttgttcact gtccccaaac ctatggaagt tgttgctata catgttggaa atgtgttttt 2401 cccccatgaa accattcttc agacatcagt caatggaaga aatggctatg aacagaaact 2461 acatttctac tatgatcaga agaacatgat tttacaagta taacagtttt gagtaattca 2521 agcctctaaa cagacaggaa tttagaaaaa gtcaatgtac ttgtttgaat atttgtttta 2581 ataccacagc tatttagaag catcatcacg acacatttgc cttcagtctt ggtaaaacat 2641 tacttattta actgattaaa aataccttct atgtattagt gtcaactttt aacttttggg 2701 cgtaagacaa agtgtagttt tgtatacaga gaagaaaacc tcaagtaata ggcattttaa 2761 gtaaaagtct acctgtgttt ttttctaaaa aggctgctca caagttctat ttcttgaaga 2821 ataaattcta cctccttgtg ttgcactgaa caggttctct tcctggcatc ataaggagtt 2881 ggtgtaatca ttttaaattc cactgaaaat ttaacagtat ccccttctca tcgaagggat 2941 tgtgtatctg tgcttctaat attagttggc tttcataaat catgttgttg tgtgtatatg 3001 tatttaagat gtacatttaa taatatcaaa gagaagatgc ctgttaattt ataatgtatt 3061 tgaaaattac atgttttttc atttgtaaaa atgagtcatt tgtttaaaca atctttcatg 3121 tcttgtcata caaatttata aaggtctgca ctcctttatc tgtaattgta attccaaaat 3181 ccaaaaagct ctgaaaacaa ggtttccata agcttggtga caaaattcat ttgcttgcaa 3241 tctaatctga actgaccttg aatcttttta tcccatttag tgtgaatatt cctttatttt 3301 gctgcttgat gatgagaggg agggctgctg ccacagactg tggtgagggc tggttaatgt 3361 agtatggtat atgcacaaaa ctacttttct aaaatctaaa atttcataat tctgaaacaa 3421 cttgccccaa gggtttcaga gaaaggactg tggacctcta tcatctgcta agtaatttag 3481 aagatattat ttgtcttaaa aaatgtgaaa tgcttttata ttctaatagt ttttcacttt 3541 gtgtattaaa tggtttttaa attaaaaaaa aaaaaaaaa 1 gcccgcgtta agattcccgc attttaatgt tttcaggggg gtgtcatagc cccgggtttg 61 gccgccccag ccccgccttc cccgccccgg ggagcccgcc cccttccccg cgtccctgcc 121 gacagagtta gcacgacatc agtatgagct ggtcaccttc cctgacaacg cagacatgtg 181 gggcctggga aatgaaagag cgccttggga cagggggatt tggaaatgtc atccgatggc 241 acaatcagga aacaggtgag cagattgcca tcaagcagtg ccggcaggag ctcagccccc 301 ggaaccgaga gcggtggtgc ctggagatcc agatcatgag aaggctgacc caccccaatg 361 tggtggctgc ccgagatgtc cctgagggga tgcagaactt ggcgcccaat gacctgcccc 421 tgctggccat ggagtactgc caaggaggag atctccggaa gtacctgaac cagtttgaga 481 actgctgtgg tctgcgggaa ggtgccatcc tcaccttgct gagtgacatt gcctctgcgc 541 ttagatacct tcatgaaaac agaatcatcc atcgggatct aaagccagaa aacatcgtcc 601 tgcagcaagg agaacagagg ttaatacaca aaattattga cctaggatat gccaaggagc 661 tggatcaggg cagtctttgc acatcattcg tggggaccct gcagtacctg gccccagagc 721 tactggagca gcagaagtac acagtgaccg tcgactactg gagcttcggc accctggcct 781 ttgagtgcat cacgggcttc cggcccttcc tccccaactg gcagcccgtg cagtggcatt 841 caaaagtgcg gcagaagagt gaggtggaca ttgttgttag cgaagacttg aatggaacgg 901 tgaagttttc aagctcttta ccctacccca ataatcttaa cagtgtcctg gctgagcgac 961 tggagaagtg gctgcaactg atgctgatgt ggcacccccg acagaggggc acggatccca 1021 cgtatgggcc caatggctgc ttcaaggccc tggatgacat cttaaactta aagctggttc 1081 atatcttgaa catggtcacg ggcaccatcc acacctaccc tgtgacagag gatgagagtc 1141 tgcagagctt gaaggccaga atccaacagg acacgggcat cccagaggag gaccaggagc 1201 tgctgcagga agcgggcctg gcgttgatcc ccgataagcc tgccactcag tgtatttcag 1261 acggcaagtt aaatgagggc cacacattgg acatggatct tgtttttctc tttgacaaca 1321 gtaaaatcac ctatgagact cagatctccc cacggcccca acctgaaagt gtcagctgta 1381 tccttcaaga gcccaagagg aatctcgcct tcttccagct gaggaaggtg tggggccagg 1441 tctggcacag catccagacc ctgaaqgaag attgcaaccg gctgcagcag ggacagcgag 1501 ccgccatgat gaatctcctc cgaaacaaca gctgcctctc caaaatgaag aattccatgg 1561 cttccatgtc tcagcagctc aaggccaagt tggatttctt caaaaccagc atccagattg 1621 acctggagaa gtacagcgag caaaccgagt ttgggatcac atcagataaa ctgctgctgg 1681 cctggaggga aatggagcag gctgtggagc tctgtgggcg ggagaacgaa qtgaaactcc 1741 tggtagaacg gatgatggct ctgcagaccg acattgtgga cttacagagg agccccatgg 1801 gccggaagca ggggggaacg ctggacgacc tagaggagca agcaagggag ctgtacagga 1861 gactaaggga aaaacctcga gaccagcgaa ctgagggtga cagtcaggaa atggtacggc 1921 tgctgcttca ggcaattcag agcttcgaga agaaagtgcg agtgatctat acgcagctca 1981 gtaaaactgt ggtttgcaag cagaaggcgc tggaactgtt gcccaaggtg gaagaggtgg 2041 tgagcttaat gaatgaggat gagaagactg ttgtccggct gcaggagaag cggcagaagg 2101 agctctggaa tctcctgaag attgcttgta gcaaggtccg tggtcctgtc agtggaagcc WO 00/09525 PCT/US99/17712 EPI-109 971 2161 cggatagcat gaatgcc-ct cgacttagcc agcctgggca gctgatgtct cagccctcca 2221 cggcctccaa cagcttacct gagccagcca agaagagtga agaactggtg gctgaagcac 2281 ataacctctg caccctgcta gaaaatgcca tacaggacac tgtgagggaa caagaccaga 2341 gtttcacggc cctagactgg agctggttac agacggaaga agaagagcac agctgcctgg 2401 agcaggcctc atgatgtggg gggactcgac cccctgacat ggggcagccc atagcaggcc 2461 ttgtgcagtg gggggactcg accccctgac atggggctgc ctggagcagg ccgcgtgacg 2521 tggggctgcc tggccgcggc tctcacatgg tggttcctgc tgcactgatg gcccaggggt 2581 ctctggtatc cagatggagc tctcgcttcc tcagcagctg tgactttcac ccaggaccca 2641 ggacgcagcc ctccgtgggc actgccggcg ccttgtctgc acactggagg tcctccatta 2701 cagaggccca gcgcacatcg ctggccccac aaacgttcag gggtacagcc atggcagctc 2761 cttcctctgc cgtqagaaaa gtgcttggag tacggtttgc cacacacgtg actggacagt 2821 gtccaattca aatctttcag ggcagagtcc gagcagcgct tggtgacagc ctgtcctctc 2881 ctgctctcca aaggccctgc tccctgtcct ctctcacttt acagcttgtg tttcttctgg 2941 attcagcttc tcctaaacag acagtttaat tatagttgcg gcctggcccc atcctcactt 3001 cctcttttta tttcactgct gctaaaattg tgtttttacc tacaaaaaaa aaaaaaaa 1 ggcacgagca tggcccttgt gatccaggtg gggaaactaa ggcccagaga agtgaggacc 61 ccgcagacta tcaatcccag tctcttcccc tcactccctg tgaagctctc cagcatcatc 121 gaggtcccat cagcccttgcz cctgttggat gaataggcac ctctggaaga gccaactgtg 181 tgagatggtg cagcccagtg gtggcccggc agcagatcag gacgtactgg gcgaagagtc 241 tcctctgggg aagccagcca tgctgcacct gccttcagaa cagggcgctc ctgagaccct 301 ccagcgctgc ctggaggaga atcaagagct ccgagatgcc atccggcaga gcaaccagat 361 tctgcgggag cgctgcgagg agcttctgca tttccaagcc agccagaggg aggagaagga 421 gttcctcatg tgcaagttcc aggaggccag gaaactggtg gagagactcg gcctggagaa 481 gctcgatctg aagaggcaga aggagcaggc tctgcgggag gtggagcacc tgaagagatg 541 ccagcagcag atggctgagg acaaggcctc tgtgaaagcc caggtgacgt ccttgctcgg 601 ggagctgcag gagagccaga gtcgcttgga ggctgccact aaggaatgcc aggctctgga 661 gggtcgggcc cgggcggcca gcgagcaggc gcggcagctg gagagtgagc gcgaggcgct 721 gcagcagcag cacagcgtgc aggtggacca gctgcgcatg cagggccaga gcgtggaggc 781 cgcgctccgc atggagcgcc aggccgcctc ggaggagaag aggaagctgg cccagttgca 841 ggtggcctat caccagctct tccaagaata cgacaaccac atcaagagca gcgtggtggg 901 cagtgagcgg aagcgaggaa tgcagctgga agatctcaaa cagcagctcc agcaggccga 961 ggaggccctg gtggccaaac aggaggtgat cgataagctg aaggaggagg ccgagcagca 1021 caagattgtg atggagaccg ttccggtgct gaaggcccag gcggatatct acaaggcgga 1081 cttccaggct gagaggcagg cccgggagaa gctggccgag aagaaggagc tcctgcagga 1141 gcagctggag cagctgcaga gggagtacag caaactgaag gccagctgtc aggagtcggc 1201 caggatcgag gacatgagga agcggcatgt cgaggtctcc caggccccct tgccccccgc 1261 ccctgcctac ctctcctctc ccctggccct gcccagccag aggaggagcc cccccgagga 1321 gccacctgac ttctgctgtc ccaagtgcca gtatcaggcc cctgatatgg acaccctgca 1381 gatacatgtc atggagtgca ttgagtaggg ccggccagtg caaggccact gcctgcccga 1441 ggacgtgccc gggaccgtgc agtctgcgct ttcctctccc gcctgcctag cccaggatga 1501 agggctgggt ggccacaact gggatgccac ctggagcccc acccaggagc tggccgcggc 1561 accttacgct tcagctgttg atccgctggt cccctctttt ggggtagatg cggccccgat 1621 caggcctgac tcgctgctct ttttgttccc ttctgtctgc tcgaaccact tgcctcgggc 1681 taatccctcc ctcttcctcc acccggcact ggggaagtca agaatggggc ctggggctct 1741 cagggagaac tgcttcccct ggcagagctg ggtggcagct cttcctccca ccggacaccg 1801 acccgcccgc cgctgtgccc tgggagtgct gccctcttac catgcacacg ggtgctctcc 1861 ttttgggctg catgctattc cattttgcag ccagaccgat gtgtatttaa ccagtcacta 1921 ttgatggaca tttgggttgt ttcccatctt tttgttacca taaataatgg catagtaaaa 1981 aaaaaaaaaa aaaa (2) INFORMATION FOR SEQ ID NO:2718: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2718 1 gaattcctct ggtcctcatc caggtgcgcg ggaagcaggt gcccaggaga gaggggataa 61 tgaagattcc atgctgatga tcccaaagat tgaacctgca gaccaagcgc aaagtagaaa 121 ctgaaagtac actgctggcg gatcctacgg aagttatgga aaaggcaaag cgcagagcca 181 cgccgtagtg tgtgccgccc cccttgggat ggatgaaact gcagtcgcgg cgtgggtaag 241 aggaaccagc tgcagagatc accctgccca acacagactc ggcaactccg cggaagacca 301 gggtcctggg agtgactatg ggcggtgaga gcttgctcct gctccagttg cggtcatcat 361 gactacgccc gcctcccgca gaccatgttc catgtttctt ttaggtatat ctttggactt 421 cctcccctga tccttgttct gttgccagta gcatcatctg attgtgatat tgaaggtaaa 481 gatggcaaac aatatgagag tgttctaatg gtcagcatcg atcaattatt ggacagcatg 541 aaagaaattg gtagcaattg cctgaataat gaatttaact tttttaaaag acatatctgt 601 gatgctaata aggaaggtat gtttttattc cgtgctgctc gcaagttgag gcaatttctt 661 aaaatgaata gcactggtga ttttgatctc cacttattaa aagtttcaga aggcacaaca WO 00/09525 PCT/US99/17712 EPI-109 972 721 atactgttga actgcactgg ccaggttaaa ggaagaaaac cagctgccct gggtgaagcc 781 caaccaacaa agagtttgga agaaaataaa tctttaaagg aacagaaaaa actgaatgac 841 ttgtgtttcc taaagagact attacaagag ataaaaactt gttggaataa aattttgatg 901 ggcactaaag aacactgaaa aatatggagt ggcaatatag aaacacgaac tttagctgca 961 tcctccaaga atctatctgc ttatgcagtt tttcagagtg gaatgcttcc tagaagttac 1021 tgaatgcacc atggtcaaaa cggattaggg catttgagaa atgcatattg tattactaga 1081 agatgaatac aaacaatgga aactgaatgc tccagtcaac aaactatttc ttatatatgt 1141 gaacatttat caatcagtat aattctgtac tgatttttgt aagacaatcc atgtaaggta 1201 tcagttgcaa taatacttct caaacctgtt taaatatttc aagacattaa atctatgaag 1261 tatataatgg tttcaaagat tcaaaattga cattgcttta ctgtcaaaat aattttatgg 1321 ctcactatga atctattata ctgtattaag agtgaaaatt gtcttcttct gtgctggaga 1381 tgttttagag ttaacaatga tatatggata atgccggtga gaataagaga gtcataaacc 1441 ttaagtaagc aacagcataa caaggtccaa gatacctaaa agagatttca agagatttaa 1501 ttaatcatga atgtgtaaca cagtgccttc aataaatggt atagcaaatg ttttgacatg 1561 aaaaaaggac aatttcaaaa aaataaaat (2) INFORMATION FOR SEQ ID NO:2719: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2719 1 gatcaaaatt tttacctatt atgcatttga tatataaata agtatataaa tgcacacaca 61 gacacagcaa tgatggtgaa cagtcttcat acaattatat ggatgaatct cataaaatgc 121 tgagttaaag aaatcagacc aaagaacata tactgaaaga ttctctctat atacaaagtt 181 caaaaatagg tggaccaatt catggtggtg ttagaaatca gaagagaggc tacctttgtg 241 gggaggggac agtttaatgc ccagaagcgg taaataagga atcctctggg gagtggtaat 301 gatctggatg ctggctacag gatgtgttgg ttgtaaaaat gcattttttt atatctagct 361 ttttccatgt gtatattata cttcaaagaa gttcagttaa taatttctca tgtcactgta 421 gagtagctca gttagcccca gcaagcctct ggcttaatct tgttttacct taagccatca 481 gtcatttaca agtaggaaaa ttcacaggga aagttagagt ataaaatcca gaatgaaggt 541 ttactgggta agagtctctc cattttccaa agcccgttta tttcttgatt ccagttctta 601 agaagtctca gcattgtgtc tttttcatgt atcttacaag aagacagcat gtgcttctaa 661 cacctgatac attgtatcta ccagcacttg gtaaacagaa aagaaccaca tttttcttgt 721 aggagaaatt tggtgcctat ttcctaccag gcaccaataa gtgggaccaa taggtgggat 781 taaagataca gtagaaagta tttaaaactt gccagggggc aatagtctga aaataagtaa 841 attggtgcta tagaatggaa gttacaggct tctttctttt ttcccacaag atctgctcct 901 tgagccccta gagacttttc tgtctgttac tgtttcttca ttcctcatct gcagagccag 961 ccctgagaag tgcagaccaa agccagggaa ggctctgcaa agatgtacaa atggaagtca 1021 ccttaataac ctctgactgc tgcgcataat acatttcact caaaagaggg gttaaacaat 1081 ggaacagaat acagaggcca gaaataatgc tgaacactga caaccatctg atctttgaca 1141 aaatccacaa aaacaagcaa tggagaaagg actccctatt ccataatggt gctgggataa 1201 ctgtctagct atatacagaa gattgaacct gggccccttc cttacatcat atacaaaaaa 1261 taactcaaga tggagtaaag acttaaatct aaaaccaaac actataaaaa ccctggaaga 1321 tagcctggga aataccattc tggacatagg acctggcaaa gacttcatga caagacacca 1381 aaagcaatag caacaaaaac caaattgact aatgaaacta atgaaactct ttagttgtac 1441 aacagatagt ttatctgtac aacaaaataa actatcaaca gagtaaacaa cctacagaat 1501 ggaaaaattt tttgcaaact atgcatctga caaaggtcta atatccagaa tctataagga 1561 atttaaacaa atttacaagc aaaaaaatga cctcattaaa aagtgggcaa aggacatgaa 1621 cagatgcttt tcaaaataag acattcacac atccaacaac catatgaaaa gatgtttaac 1681 atcactaatc attagaggaa tacaaatcaa aagcataata agataccatc taataccagt 1741 aggaatgact actattaaaa agtcagacaa taacagatgc tggtgaaggt tgtggagaaa 1801 agggaatgtt tatgcactgc tagtgggaat gtaaactagt tcagccattg tggaagagag 1861 tgtggtgatt cctcaaagaa tgtaaaaccg aactgccttt caatccagca atcccattat 1921 tggatataca ccaaaaggaa tagaaattgt tttaccgtaa aggcgcatgc atgcatatgt 1981 tcattacagc actatttacg atagcaaaga catggaatcg tctaaatgcc catcagtggt 2041 agactagcta aaaaaaaaaa aatgtggtac atatacatca cagaatagta tgcagccata 2101 aaaatgaaca agatcatcat gtcctttgca gcaacatgga tgtagttgga ggccattatc 2161 ctaagcaaat taatgcagga acagaaagcc aaataccaca tgttctcatt tataagtgac 2221 agctaaatat tgagtacaca tggacacaaa gaagggaaca atagacatgg gacctacttg 2281 agaatagagg gtgggaggag ggtgaggatc aaaaagtacc cataggacac tgtgcttatt 2341 acctgggtga tgaaataatt tgcacaccaa acccctgtga cacacaattt acctatatag 2401. aaaacctgtg catgtacccc tgaacctaaa agttaatggt gggggggtgg ggttaagcta 2461 ctttgtggta taaatctgag cattcatatt aaaataaaat atttacctca ttagagtaat 2521 taacatttat taagcaaaga gccaagtacc ttacacacat gatgtttaat ctcacaatga 2581 tctttaatct cataacaacc gtccattgta tgtacatatg tggaaattga gccttggaga 2641 gattaaatgc atggggcatg ccatttgact agaaactgga agcatcagga tttaaactca 2701 gttctgaatg gttttgtagg ctttgttttt tccacattat agcatggcct gccatgaaga 2761 acaggtcctt tctggtgttt gtcttgtttg gtttaagtga agcaaatatt tatttaaata 2821 ttcaagatat gctgttaaat ttttactcaa aaatttgagt acagtatgga tcttctgaag 2881 ccaaataact cttattcaat gcttagttga gaaattttat ggagtagttc tcaattttta 2941 tgtagttcca ctgcaaaggt aagtcttatg gaaagattca ctgtaatttt ttttcctcat WO 00/09525 PCT/US99/17712 EPI-109 973 3001 ttggacatca gctttttctt ttcctcagac ccgctgaaag ataattttta aaataaaaac 3061 cttgttttta tatcaagtgg ggacattttt tccaaatgaa aaccgtgtat tcattttata 3121 tgataaaatc aatgttatta tttttaaaat tttgatttaa aaatcattaa aaataaattt 3181 tcagatatta cctgaaattc taccatccag agataatagt gcttaaagat ttgatatata 3241 gacacacaca catatataca tatatatcat cctaaacttc tttgtataaa tgtatataaa 3301 gtttttaata aaaactagga gattaatgcc ctttgaatga aaataaatac aatgtgtatg 3361 ctttaacatc ttgcctttac tttataacat ttatcacagc agtcatgaga taatgattta 3421 catggtcatt gttagtaagc taatagctaa gtgcatgaac tctggagcta gcctccctgg 3481 attttaatcc cagatctgtc actgaccagc tgagcaatac taggtaaatt gctcttgttc 3541 cttagtttct tcatctgtaa aatagagata aaaataatat ccacctcata ggattggtgt 3601 gagcattaaa tgagcatacg tatgtaggcc acttaacaac aatgccttca catactgaac 3661 acaaatatac gagctgttgt cttattgggc tcatgttttt cctaccacta agccgcatgc 3721 atgcaaggac catgttggtt ttgttccaca ttgcatcccc aacctggtat acagtgtgca 3781 ttcaatagtt gttgactatt attactagtg gcatttaaca aatatctgtt aaatgagtga 3841 agaaataccc atttactgca agtgtgtcta atattgatgg cataatgggg gaaactcaaa 3901 ctctggagtc aaacaggttt taaaacctta ttccctcatc ctcagttatt gacgtttttt 3961 ttttggcagg tgtgtgtgtg ggacaactta ttgaactttt ctgaatttcc agcttcgcat 4021 atataaaata gagatagtga ttcattcttg caatgtatgg atttgagaca attgtgtaag 4081 tttatcaata aatagtagct atttttgtat aagtattaca tataatatcc aggccactgc 4141 tttgcataac ccaaaagggg caccattcat gcagaataca acataaatgg tgtccctgga 4201 gcagtgcagt ataggaaccc tgaggggacc tacagtatac tttatagttc atagattaca 4261 aattatccct ttatcagagt ctctcaaggt tggatgtatt tgaggtccat aagagcaatt 4321 taggattaac agtagctgca gaaaccatct gcagtgatat tctcatttta aatccgcggg 4381 aaagaagaca gctataaact tgggacctgg gtttaagcat tttaaatgcc aagttcacca 4441 ttttctaaaa cacaacaaat acccagtgag agagggagaa gggaagtaaa tgcctctgaa 4501 taagcaagtt aatgtcagta gttgtactgt atgcatattg atgaacaata gaggaaccaa 4561 tgtccaatca gatgagcagg atatttggca ataacaagtt gcctttgagg aaaaatgatt 4621 ttcttggcaa gttctttatc agcattacaa agctaaaagc tacgcttatc atcacttata 4681 ctagcatacc ctgttgtgca aatgctgtct gtgtttgcat ctgctattgt tgatgcctgg 4741 tgcatgaatc aggactccag cccacaagtt ttcccagaac tttcttatgg ccatcatctt 4801 taagtgtctg gtgaacagtc atagtttggt acacaaaagg gtcaacctgg gggatggcta 4861 gggtttgact cagtcgttac atttcaatag agcaggaagg ggaaatggtg gcctgtaacc 4921 tcagggaatt ttgccagttg gtccacccca ctctctctct cctgctctga ggaagtggca 4981 cagcctagaa cagcaccaca ggtgagagaa atgcaaaccc taaccagaga agcagactct 5041 ttgccagtag taatagttca ggaccaccac cagcttttat taaaattttt aataacactc 5101 aagtattggc agaaagaaat aatcttgggt taactataac tagaatattg actcttcctc 5161 tgtggaagaa tcagccaatc acatttgttt acatcagttc ccctgaagaa gaaaaataca 5221 ctgatgttgc agcaagacaa atttaagcta gatgtaaata acttccttta gcctgtaatg 5281 ctaggctaat tacatattgg aactattttt tcagggaaga attgtgtagg gtttcaggga 5341 agaattctga agaaaatata gagctgaaat gatcttgcag ctcactgaaa ctgcagggtt 5401 tagatccaca ctgatactcg ttctattatc actgtaatga aggctgatgg aataagtaaa 5461 aatgttttgt attagtatgt ttttacactt atttgcaagg cataaatagg ttaggttttg 5521 atcttaattt aattctaaca tgtattgtgc acaagctgtg agcagttttc aggagttagg 5581 tatctggcca tgactgattt ttcaggagtt aatcatctgg tagaagggtc atacacaata 5641 ggaagatgtg tgtgacaggt tgtgatcatt actataatca cacagagagc tgtagaattt 5701 taggctggca gggtggctca cgcctgtaat cccagcactt tgggaggcca aggcaggcgg 5761 atcaagaggt caggagatgg agaccatcct ggctaacacg gtgaaacccc gtctgtacta 5821 aaaatacaaa aaaaaaaaaa agccaggcgt ggtggtgggc gcctgtagtc ccagctactt 5881 gggaggctga ggcaggagaa tggcgtgaac ccgggaggtg gagcttgcag tgagccgaga 5941 tcgcatcact gcaatccaac ctgggcgaca gagggagact cagtctcaaa aaaaaaaaaa 6001 aaaaaaagtc atgttagatc cagaggggta gcaactgggg ctgggctgtc agtcaactca 6061 gtcaactcag tcaactctgc tcccccacag gagatgccag tgatgcattt tcatggccaa 6121 cattgtcagt cagcatcatt gaattactcc tgattataga gacacagctg caaacgattc 6181 cccattaaat atgatgtttc ttgcaatgtt tggaaggtac tcctttttag taagggaaat 6241 cccctcttct ggcttgctga aagttttttc tttccatttt aaaaatcgtg aattcctttt 6301 tgcaatattg aggtggttat atggtttctc ttctctaatc tgttaatatg gtgatttaat 6361 ggttagaaat tttctaatgt aaattccact catattgcag aaataaacct aaactgagca 6421 tgaggctata ttttttattt gcttctatat ttggttgcta tacagtatta tgtttaagat 6481 ttgttcacat atatttgtga atgggattgg actatttttc cttcttgccg atttttatct 6541 ggtttttaaa ttaaggatat tttagactta tgaaatattt ggcaaacaat ccttggcaag 6601 taattttttg gggaatttgt tttggctatt ttgagtatta cccaatatat tttaattaag 6661 ttattcttaa tgttttctta attaaaaaaa ttacctactc tagagatatt ctttatgtac 6721 tccagatttt gtctatttat accacttttc ttttttcctc gatgagtgtc atagatgttc 6781 atctattttt ttatcttctt tgatcttctc ttattccttg tttctattaa cttctgaagt 6841 ttattatttt cttttttcca cttccttatg gtttattctt tcaatttttc tctaacttct 6901 taagttgggt gtttaatttt tagcttgctt tgctttttta ggataagcat taaaactaca 6961 aattttcctt gttattcttt tgctgcaccc caaattgttg atatttctat tgtctaattt 7021 ctattcaatt agaatacttt aaagtttctt tttggttttt aaaaactaac tttttaaatt 7081 gacaaataaa aattgtgtat atttattgtg cacagcatat ggctttgaaa tatatgtaca 7141 ttgtggaatg gctaaattta gcttattaat gtatgcatta tctcacatac ttatcatttt 7201 ttgtggtgag agctatgtga cttttgaact tatgagttat ttaaatattt ttaaattatt 7261 aagcatattg ggattttaag taatttacct ttttattatt aacttataac aagtagaaca 7321 gttaacctgt atgattctac atcattgaaa tttattgaca tttgcttcat agtctattat 7381 atggtctact tttgttcatg ttacatctgt agtagaattg gctaatagtt gagtaaagta 7441 cacatatgtc tatgaaatca agtgtaatcc agagaaaaag agaaatttac tgaatatatt WO 00/09525 PCT/US99/17712 EPI-109 974 7501 gttctaggtg ctattatatg ttgtcatgtt taatcctcac cacaattgta tgaggcagcc 7561 ataattaatt ccactttaca catgaggagc ctgagggtta aaaaaaaagc tagctctact 7621 atttgtaaag aatgaagcaa agatacaaat gaaggcccac atatcctata actagatatt 7681 taagcatttt aattcaagct ttaaaactgc taaataaaat gtgctccaat ttctatattg 7741 acagacatac cttcctaatg agctggggtt cgaatttaga aatctttgat gcttcagagt 7801 ccacactgaa atgtggaggc acatagtgag ttggtcccca gccttcagtc cacccacctt 7861 ctctttacta aatcacctt cacatacatg tatgaacacc ccagcctcca agtccaaacc 7921 ctaaacaaaa tgggacaccc ttgtgcatac acagagacac agcccatcct caggaaaacc 7981 tggaaaagtc catacaagtt ctggaagcaa gcttgggacg gtttcagtag tgtggtctat 8041 aagggaggcc tcagaagaca ggttttctta attctgtgaa cttctcccac agtagaaagg 8101 gtgctggagg agggtcagag tgaggacttc taaagcatgg gtcctgagta ggggccactc 8161 ttgcccaagt ctaagaaggg tactagaata gcacactact actagatact agaacccaga 8221 tacaagcaca ggtcttctga aattaataat aataataact attaccatta ttataccagt 8281 agctgtcatt tatttagtgc ttattatttg ccagtcactg ttctaaattc tttacatgta 8341 ttatacaact gccatataac tgccatatga gggatgtacc ctcattgtca ccattttacc 8401 gatgagaaaa ctggcataaa acgtttaagt aacttgtcca agttacagag cttagtgaag 8461 ccacaatgtt gctcaatttg ctctcaaact tcaaagggat gggaaggaca cctaagtcat 8521 agagtcttta agaatcagag ctagaaggaa tcttagatgt tatctagtca gcctcctccc 8581 attacagtcc aagagaagat ggccctgagt tacttgtagc tatttttgca tgtgaattgc 8641 aagtgaatat acattctact gaagataaaa gatatttaaa gatatcgctg gatataggaa 8701 cagtggtttt aaatctctag gctttaactt ttctcagaac aagaaatcct ttttggtttt 8761 aatctatatg cacatctgta tttttctcaa ttatcgggta gtaaaatata acttttcttc 8821 tgtaatattt tttaacttta atgagtgttc ctcataatag aaaagtttgg aaaccattgc 8881 tatgggtata tactttctaa agggatagta atttctctag aatattcatt taatgctcca 8941 gaagtaatta gcacaattgt gcaagtctgt gcatcatcaa ctatacattc tgcctgttta 9001 ctccaaatcc acatgaaact gattatacag tcaaaggcga gcccagtgga gaggcatttt 9061 tggagacttc ctggtacatt gagacagggt cggccagtct gcgttagggt cttggtcaaa 9121 actgcatttc tgaaactaaa ctcagattgc tttcttttaa ggggtcagaa ctgattcaaa 9181 tctacatttt taaaagcctt agatgtgggg cttttcctat tcccagtctc cgctattggt 9241 ctttgtgaat ccacaggcaa tttggccaca tccttgactc tctcttatat taagaattaa 9301 acagctaagt tcatgcagag gaaatataac aaaggaggga ctttcctaca agatctttga 9361 aaaatggaac atttgcataa gtcatattta gccagaactg ttgttttata ttttcctttc 9421 tgaatacttt gttacacctc ctcccagcca accccccccc tccctgaccc caactagtca 9481 gagaccaaag ccttcacaat ggtttacact tgaaccttcc tggccccacc ctcatcatca 9541 cgcctgaata attacattca ctgactggtc tcccctgctt ccgtttatct ccactcctaa 9601 accctctgac accttaatct tcccagaata ccattgtgat cctgttccac tcttgctcaa 9661 gttttcccag aaactagagt acaaacttta taagctttag agttgaaagc cactctatct 9721 ctttttcatc cccaggtctc tgccaaggca gtataacctg tccaacatct ctaacttcaa 9781 tacctttgtc ttagatacta gactctcctc ctggtttcta attaaacctg atctaggatc 9841 taattttgcc tctgaattct gttgcccttt gccaagtgat ctcttcctcc tctgagccgc 9901 agcatctctg agcttgcaca cttagcatag ccatagcaca cacagcctta gcttgcagtt 9961 cagggtgttt accttccctc cccttccaga tgctggatcc ccagggatag gaactctgcc 10021 cttatgtgtc catagcccct ggtagtatgt cttgcagtcg tacattttca gcaaatgttt 10081 aattggttaa ttgaagacaa ctgtcccatg ccttaagcct ctctttttgc taaacatgcc 10141 tgtgtccttt gtcattgaac aactattttg atctattttc ttcctgacat aggggtcagt 10201 tccgaggatg ctgaaatcaa gagacatagc ttattctctc aaaattgctt tcaagagtga 10261 ttttgttgtg aattgagaac tggctgccta cttttggact acccacttca gcaagagtgt 10321 ttgaaaccaa atctattcta agtaattttt tattcccttt tctctatggc attagacaca 10381 cagctctttt aaactacctt tcgttatcta ttaaacagac attcagtaac tctatagaca 10441 ctgtctagct atatgaactt agacaaacta atatctctga gcttcagttt cttaaaattt 10501 aaaatgagga caataccatc tatggccggg gattaaatgc tatgaggaat gtaaaccaga 10561 tgtcaggtac catctctcta aaatccagat aaaatgaatt aaaaatactg gccgcaaacc 10621 ctctctaaga gttctcaaaa ttctcagaga gcttaatttt catgctcacc atagcaccga 10681 ttttcttcta aatattttgt ttctaccaaa atattttgtc ccaattttgc cttttatggc 10741 tatttcttca tatccacttt cccaaactaa agaagcagcc ccttcacctt aaactcctcc 10801 ttcaaagcaa cctaaataca ggtctgggtt tgtattccta gtgggatgtt acagaggtta 10861 gtgtgatgca gaggaggagt catgctgttt aaatccatac tagtccccag aggccaggct 10921 gcttctgcca cccctacccc tcccgccaca gagctcttca gcttctcaca tttctagttc 10981 ttctctctct actttcatta ccttctctct tttttttttt cttctcatgt gctcacggga 11041 gcagagaaaa ttaactcctc taagttttct taacacagag tgccttaatt acatattact 11101 attgtttgag ttcctgccaa cactacgtct gtagggtcac acctgctata ttagaggctt 11161 atcaaaaaaa gatagctttc tcctaaaaag ggatttggat gcctactaag ataactggat 11221 gccaagataa gtttaaccta acaaacttta ttattattat tattattatt attagagata 11281 ggtacttatt ctgtcaccca gactgcagtg cagggatgca ataatagctc actgcagcct 11341 caaagtcctg agttcatgca atccttctgc ttcagctccc tgagtagcta ggactacagg 11401 catatgctac tctgcccagc tacttttaaa aaaataatta gggatggggt cttgttgtat 11461 tgcccaggct cgtctcaaac ttctggtttc aagcaatcct cctgcctttt acctccctaa 11521 ttgttggagt tacaggcatg agccacagca ctcaaccaag atttaaaaac ttttaaaaga 11581 aatcacatta cttactgtta tcatcattat ggttactacc agtgttaaaa caattggtat 11641 tgaaaacacc actaccagat caagcttcaa accaagatgt caagtaaata ttattgtcag 11701 acctctgagc ccaagcctgc aggtatacac ccagatggcc tgaagcaagt gaagaatcac 11761 aaaagaactg aaaatggccg gttcctgcct taactgatga cattccacca ttgtgatttg 11821 ttcctgcccc accttgactg agggattaac cttgtgaaat tccttcccct ggctcagaag 11881 ctccccgact gagtaccttg tgacccccac ccctgcccac aagtgaaaaa ccccctttga 11941 ctgtaatttt ccactaccca cccaaatcct ataaaacagc ctcaccccta tctcccttcg WO 00/09525 PCT/US99/17712 EPI-109 975 12001 ctgactctct tttcagactc aacctgcctg cacctaggtg attcaaaagc tttattgctc 12061 acacaaagcc tgtttggtgg tctcttcaca cagaccatgt gacatttggt gccgtaactc 12121 agatcgggga acctccctg ggagatcagt cccctgtcat cctgctcttt gctccatgag 12181 aaagatccac ctatgacctc tggtcctcag accaaccagc ccaaggaaca tctcaccaat 12241 tttaaattgg gtaagtggcc tctttttact ctcttctcca gcctctctca ctatccctca 12301 acatctttct cctttcaatc ttggcaccac gcttcaatct ctcccttccc ttaatttcag 12361 ttcctttctt tttctggtag agacagagga aacgtgttct atctgtgaac ccaaaactcc 12421 agcactggtc atggacttgg aaagacagtc ttcccttgat gtttaatcac tgcagggatg 12481 cctgcctgat tattcaccca catttcagag ctgtctgatc actgcaggga cgcctgcctg 12541 gatccttcac cttagtggca agtaccactt tgcctgggtg gcaagcacca cctctcctgg 12601 ggggcaagca ccacctctcc tggggggcaa gtacccccca accccttctc tccatgtctc 12661 caccctctct tctctgggct tgcctccttc actatgggcc accttccacc ctccattcct 12721 cccttttctc ccttagcctg tgttctcaag aacttaaaac ctcttcaact cacgtctgac 12781 ctaaaaccta aatgccttac tttcttctgc aataccgctt gaccccaata caaactcaac 12841 aatggttcca aatagcctga aaacggcact ttcaatttct ccatcccaca agatctaaat 12901 aattcttgtc gtaaaatgga caaatggtct gaggtgcctg acatctgggc attcttttac 12961 acgtcggtcc ctccctagtc tctgttccca atgcaactca tcccaaatcc tccttctttc 13021 cctcctgcct gtcccctcag tcccaacccc aagtgtcgct gagtctttcc aatcttcctt 13081 ttctactgac ccatctgacc tctcccctct tccccagact gctcctcctc aggtcgctcc 13141 ccgccaggct gaatcaggct ccaattcttc ctcagcgtcc gctcctccac cctataatcc 13201 ttctatcacc tcccctcctc acacctggtc cagcttacag tttcattctg tgactagccc 13261 tcccccacct gcccaacaat ttcctcttaa agaggtggct ggagctaaag gcatagtcaa 13321 ggttaatgct cctttttctt tatccaacct ctcccatctc agttagtatt taggcttttt 13381 ttcatcaaat atgaatacct agcccactcc atggctcatt tggcagcaac tcctagacat 13441 tttacagcct tggacccaga ggggccagaa ggtcatctta ttctcaatat gcattttatt 13501 acccaatcca ctcccaacat tagaaaaagc tccaaaagtt agactccggc cctcaaaccc 13561 cacaacagga cttaattaac cttgccttca aagcgtacaa taatagagta gaggcagcca 13621 agtagcaaca tatttctgag ttgcaattcc ttgcctccac tgtgagagaa accccagcca 13681 catctccagt acacaagaac ttcaaaatgc ctaagccaca gtggtcaagc attcctacag 13741 gacctcctcc atcaggatct tgcttcaagt gccagaaatc tggccactgg gccaaggaat 13801 gccctcagcc tgggattcct cctaagccat gttccatctg tgtgggaccc cactggaaat 13861 cggactgtcc aacttgccca gcacccactc ccagagcccc tggaactctg gcccaaggct 13921 ctctgactga ctccttccca gatcttcttg gcttagtggc tgaagactga tgctgcctga 13981 tcgcctcaga agcctcctgg accatcacag atgcttttgg taactcttac agtggagggt 14041 aagtccgtcc ccttcttaat caatgcagag gctacccact ccacattacc ttctcttcaa 14101 ggtcctgttt cccttgtctt cataaatgtt gtgggtattg atggccaggc ttctaaaccc 14161 cttaaaactc cccaactctg gtgccgattt aaacaacatt cttttataca cttcttttta 14221 gttatcccca cctgcccagt tcccttatta ggctgagaca ttttaaccaa attatttgct 14281 tccctgacta ttcctggact acagccacat ctcattgctg cccttcttcc caacccaaaa 14341 gtggcaactc ctttgccact tcctctcata tccccctacc ttaacccaca ggtatgggac 14401 acctctactc cctccctggc aacaaatcac accctcatta ctatcccatt aaaacctaat 14461 cacccttacc tgggtcaacg ccagtatccc atcccacaac aggctttaaa gggattaaag 14521 cctgttatca cttgcctgtt acaacatgtc cttttaaagc ctgtaaactc tccttacaat 14581 tcccccattt tacctgtcca aaaactggac atgccttaca ggttagttca ggatctgtgc 14641 cttatcaacc aaattgtctt gcctatccac gccatggtgc caaacccata tactctccta 14701 tcctcaatac ctccctccaa aacccctcca taacccttat tctgttctgg atctcaaaac 14761 atgctttctt tactattcat ttgcaccctt catcccagcc tctcttcact ttcacttgga 14821 ctgaccctga cacccatcag cctcagcaac ttacctgggc tgtactgccg caaggcttca 14881 tggacagccc ccattacctc agtcaaccca aatttcttct tcatccatta cctatccagg 14941 catagttctt catgaaaaca cacgtgctct ccctgctgat catgtccagc taatctcccc 15001 aaccccagga ctggcaaatt gactttactc acatgcccca aatcaggaca ctaaagtacc 15061 tcttggtctg ggtagacact ttcactggat aggtagatgc ctttcccaca gggcctaaga 15121 aggccaccgt ggtcatttct tcccttctgt cagacataat tccttggttt ggccttccca 15181 cctctataca gtctgataat ggacaagcct ttactagtca aagcacgcaa gcagtttctc 15241 aggctcttgg tattcagtga aaccttcata ccccttaccg tcctcaatcc ttaggaaagg 15301 tagaactgat taatggtctt ttaaaaacac acctcaccaa gctcagcctc caacttaaaa 15361 aggactggac agtactttta ccacttgcca ttctcagaat tcgggcctgt cctcgaaatg 15421 ctacaaggta cagcccattt aagattctgt atggacgctc ctttttatta ggccccagtc 15481 tcattccaga caccagccca acttgaactg tgccccaaaa acttgtcatc cctacaatct 15541 tctgtctagt catactccta ttcaccattc tcaactactt gtaaatgccc tgcccttttt 15601 tacagtgctg atttatactt ttcctccaaa ccatcataac tgatatctcc tggttttacc 15661 tcaaaccgcc acccttaagt ctctcttaaa gtggatagaa gatcttcagt gacaaggtac 15721 actccaatac tttcacccta ataaagccct attctttact tttatattca ctcttattct 15781 tgttcccatt cttatgccac tctctacctc tccccagcta tctccaccac actatcaatc 15841 tcactcactc tctcctagcc atttctaatc cttctttaac aaacaattgc tggctttaca 15901 atttctcttt cctccaaaat caccgagtcc tcaatttact cactgctaaa aaaggggact 15961 ctgcatattt ttaaatgaag agtgttgttt ttacctaaat caatctggcc tggtatatga 16021 caacataaaa aaaactcaag gatagagcca aaaaccttgc caaccaagca agtaattatg 16081 ctgaaccccc ttgggcactc taattagatg tcctgggttc tcccgattct taatccttta 16141 atacctgttt ttctccttct cttatgcaga ccttgtgtct tccatttagt ttctcaattc 16201 atacaaaacc gtatccaggc catcaccaat cattctatac gacaaatgtt ttaagggagg 16261 agaccacccc tcatattgtc ttatgcccaa tttctgcctc caaagaaaga agtaaaaatg 16321 aaaaggcaga aatgaaatcc acaggcagac agcctgatgc cacaccctgg gcctggtggt 16381 taagatcaac ccctgaccta atcagttatg ttatctatag attacagaca ttgtatggaa 16441 aagcactgtg aaaatccctg tcttgttctg ttcctctaat taccagtaca cgcagcccct WO 00/09525 PCT/US99/17712 EPI-109 976 16501 agtcatgtac cccctgcttg ctccccctgc ttgctcaatc agtcatgacc ctctcacgca 16561 gaccccctta gagttgtaag cccttaagag gaaaaggaat tgttcactcg gagagctcgg 16621 tttttgagac atgagtcttg ccaatgctcc cagctgaata aagcccttcc ttctttaact 16681 cagtgtctga ggggttttgt ctgtgtcttg tcctgctaca gtttcatcta acaaccccat 16741 aatatcaccc cttaccacaa aatcttcctt cagcttaatc tctcccactc taggttctca 16801 cgccacccct aatcctgctc gaagcagccc tgagaaacat cgcccgttat ctctccacac 16861 cacccccaaa aattttcact gccccaacac tttaccacta tttcgtttta tttttcttat 16921 taatataaga agatagaaat gtcaggcctc tgagcccaag cctgcacgta tacatccaca 16981 tggcctgaag caagtgaaga atcacaaaag aagtgaaaat ggctggttcc tgccttaact 17041 gatgatattc caccattgtg atttgttcct gcgccacctt gactgaggga ttaaccttgt 17101 gaaattcctt cccctggctc agaagctccc ccactgagca ccttgtgacc cccaccccta 17161 cccacaagtg aaaaaccccc tttgactgta attttccact acccacccaa atcctataaa 17221 acagccccac cccatctccc tttgctgact ctatttttgg actcagccca cctgcaccca 17281 ggtgattcaa aagcttcatt gctcacacaa agcctgtttg gtggtctctt cacaccgaca 17341 cgcgtgataa ttattatatt acttttaact aaaacccttt cagagtctcg cagggaaggc 17401 tgtatatatc tcataaaatg ttggggccca ctggatcaga caaggccaca aaggccaaag 17461 ggaagtaaag atctcattat ttctcctaat aatttccctg tcctttgtca taaatggtgg 17521 gtaggctgtt atggtgatgg cagattttct ttccataaaa tgtccataat aggacatttg 17581 aacagaaggg aaaaatcaaa ttgctgaagt tgaaagaggg caatgcaaag aactttggag 17641 aaagaactgt acagagaagt caactqgcag atgggaggaa gtttaagggg aaaaatatag 17701 atgtctaaag aatacattta ttcattttcc acagtgcaat ttggacaaga agcctctttc 17761 ttgcttcttt ctattctcat taaatcatta gagctcaagc aatccttctg cctcagcttc 17821 ccgactagct aggactacag gtatgtgcta ctatgcccag ctaatttttt aaaaattaga 17881 ttttaatttg gtgaactatt tctgtaggaa actacaataa tacagcccag gcacattgat 17941 cttgggtgaa caaatcagaa ggaatgaata attctgtgtt cctgggactc tgacaatttc 18001 atgaacttgg tactctgagt aaagcatagg aggagttatt tcataaaatg tggagcacaa 18061 tcatgtgaca aagataatgg gatccccatt tcataaataa atctgaagtt cagagagagt 18121 aacaactggc cagggtcaca tcacggagac agaggcaggg ttcccactga tgcctctgac 18181 tccctgtccc aggcccttcc tcctcccgca agcagaagtg cagggggcag agctgaccct 18241 gtgcagtgaa aatctgaggg ctgagttcct attggaacac aagtgaaaga cttcctggct 18301 tctaatctca ggataaggac tcagagctcc atctgttcca gccttaggat aagaaccaga 18361 atcttacacc atgaaagcat gaaaggtaag atttgagtga ggaaaaaaaa aaaaaaagtc 18421 tgtgtttcag attcagttca caaagcagtt tcatacttaa ggtaccatca caataaccct 18481 gtggggtaag caaggcaaat ttcattcttg ttttatgggc ataggaagta agtctcaggg 18541 aggttaagac caaggtttct ggagaatttt atattatgaa tcttgattta tgggattact 18601 attatgtaat tcctaagatc atataggaat cctagagctt gaatatagaa ctttattttt 18661 aaatctatat acatcataat tacaaggagt agtgtccatt tgggttcctt ggccctgatg 18721 tgttagtgga ataaacattt ttgtcagggt tgccatgtgt gtctgtgcac gtgtgcactg 18781 tacacctcca ggggatgtac cctaaaccac atgaatgtga tttgcacatc caagatttac 18841 agtgtactat agggagaatc ttttgcaaca gcttttgcta taatacagaa tctgagatgt 18901 ctttgagaaa gaaaagtgta atcattacca aaaaattatt ctcataatgt gtgcaaattt 18961 gtatgaaatc tatattggcc atgggacaag gaggtatttc cagctagctt ctgaaagggc 19021 tctattctct cataagaatt cagctgttga cattaggtga tatctgccca ggtcatcaga 19081 tgccatagag aaagagggtt tgctgaaact tatatcagca gtgcactgta tgctctttct 19141 gatttatttg aacattcatt tattgagtgt caagtaatgc actagatact ccagggatct 19201 gacacaaact ctgccctgaa ggagcatgta atctcactgg ggagaaaaca aaacatatga 19261 taatttcaaa ataacaaact aggcaaacta gttaacactt aaaaagcagg ctttattcaa 19321 atgcaaaatt gcatgttaca gggtaacctt tcagtaagaa gccaggaaga ggagctcatc 19381 atgggttgga ttagtaaagg actagttata aaagaagtgg tggggttgag ggaggcctga 19441 gatgaaattt aaagaatatg tagaatctag gtaagtggat aaaaggtctg ggggcagggg 19501 aaaggagagc atttcattgt gaatcaagga atttctccac ctgttttaac tcttccatat 19561 gacatcaaag agatgtcact tgcagctagc atttcagtga tgttttctta ctaataatat 19621 cgtgataaaa gaaacattga ctataagaaa taggaatggg tctcataaaa ggaaacagca 19681 aaacccccaa actaaaaaac agcgcaggct atttctctct tctctccttt tgcttggcac 19741 tcatgagatg ctaggtgtgg aagtcagcca actgaaaaag agaggtggct gaagaaggtg 19801 gggaggctga agccagttaa ataggatggt ccaattcaca gacggcgagg ctacagtgca 19861 aataggactc tttcaacttg agcaggaccc cattacttca ctggagttag aaagaaagga 19921 gagcgtagac tttttgaact ttctataaga gtgtacctcc acagtataca gaagacgacg 19981 tgaaatttga tctgcaagaa aactgagtcc atattcacat atgtatcaaa tttgcacttc 20041 atttagaagt gtctgtcatc aagtacagca ctgaattgaa actgaaaaca agagtcaaga 20101 aagagcaaag tcagccatct ttatattcca catgaatcct ttccctttat ggtcttattt 20161 gtttctcctc agaaaagaca aaaagctgag ctgtataaac acctgtgggc tgggggttga 20221 gggataaatg aggggcgaaa tggaagctga aggaactgtt ggtcaggtag aaatcttccc 20281 agatgcactg aaggaaacac acttcatgtt tgacgtagga ggtgccacca cacaaaacgt 20341 ttcatggaag gatttaaagg atctcatgat ttttagtatt ccaagaattt tctttcacca 20401 agggcgattt aatatgggtc attcatactg aaagaaaaac aaaagataat aagagtttaa 20461 aaattgcaaa acttggagtg ttagtagtaa aggtaaatat tcattagaga tgagaagagg 20521 agcaaggaaa tgctttcagc tggaaatctc agacaagagg ccaggcttta ggaacctctg 20581 aagatgaaca aatgtaagca aaccctagta gcagcacttc tcagattttc atgtgcttac 20641 cactcagaga tggtgttaaa atgcagactc tgattcagta ggtctgagtg gagcctgaga 20701 ttctgcaccc ctaacaagct ctttagtgat gcttatgcca ctggcgcaca gaccccactt 20761 ggagaaattt ttgtggtgca tacggtcttt gtctccagat ctaatgagtc tgaaggacag 20821 tgtagattga ttttttaaat ttatgtttat tttaatttaa tttaatttaa tttatttatt 20881 tatttatttt tgagatggag tctcactctg ttgcccagtc cggagtgcag tggcacggag 20941 gcagctcatg caaccacggc ctcctgggtt caagcgattc ttccgcctca acttcctgag WO 00/09525 PCT/US99/17712 EPI-109 977 21001 tagctgggaa tacaggcacg tgccagcaca cccagctaat ttttgtattt ttagtagaga 21061 tggggtttca ccacattggc caagctaatc tcaaactcct gacctcatga tccacctqcc 21121 acggcctccg aaagtgctgg gattacaggc gtgagccacc gagcccagct gtagattgat 21181 tttgagcagt ggaaagtcaa ggaattagaa ggcatgctta aatggaaagt gaaattggag 21241 aaaatttaaa ctcatgaaat agtggtggtt ataaactcgt gataaattat atcctgggat 21301 ataatttaat gagatggtaa cacatttagt ttaaagaaat aagtgacact ttttttgtgt 21361 gacacaactg tcttattctt ggaaaggaca aggagagaat gaaatatggt atgtcttcac 21421 agcacctttc aaagggagaa ccagattctg aggagctggt ctcatgatga actgtcaggg 21481 taaaccacag ttcagcagct gcaaatgtgc ttgccaaaat agagacaaaa aaatgtttct 21541 gaaaacaaaa tttcacatat gccctcctct gaggttggca tcatatcttc ctgtgtatct 21601 tgggtgtagc ttctatcctg ccagaattta gacagtagaa accaaatgag gtgataaaca 21661 gagtcatttt gcagaagagt caaaataacc cagcaagaaa tgaaaccaca aatgcccaag 21721 gagtcattca ttcaccattc aaaagctaat agaaatgaac acaaactact atgaaaattc 21781 acccaagaac ttaaaaaaaa aaaaaaaggc tcatggtgtt tagtgtgata gtattcattt 21841 tacctttgac ttgttctaaa aacacaccat acttctaccc cacccttcct cagtgccgtc 21901 acacaatggt ttcagtgtga aaaaaaaaac cacgttactg gaaaaggagg gtgcctggga 21961 cttgccactc taagctggta gtcaagggtc ttgagttcta aaagcatacg cgttaagagc 22021 atgattcctg gatccaaatg agtatggatc tcagcattgc catttattgt gacctcaggc 22081 tattttattt ctctgtgcct gtttctttat cagtaatgaa gatgttcata gacccttctc 22141 ccacagactt aaaggcatat ttcatgattt aagacatgta aaccattcat aacagtatac 22201 aacatggaat taatatttga taaaggttta tgattattgt aactaactCt gtcacttgct 22261 caaggcctat agaaaactta cttaattagt tcaactacaa aaagagtttg aatgtgatat 22321 ccaccaagat catattcaga cctagaattc tgtgattctt atgaattaat acagccttgg 22381 tcaataaatg agagctgggc aaataattct tctttgctag gcctttctag accatctggt 22441 gaagcattca agacttatgt tattggggcc agccttcctt tccaacttca actccacaac 22501 tcctcaataa gccatgggct caagaaagtt ctgctcagtg gcccctgaaa aatgctttca 22561 tagtctcact accataccac tgcttacaca atttccttcc tacagactgc cttcctttcc 22621 tgcttttctc catataccta aatcctatct attcttcata agcaaccttc tttataacat 22681 tttctataac caccaagcca aatgaccttt tccttcttaa atatagcacc cattggccat 22741 taccatgctc tgccttgtat ttttctgatt tttttctttc tatattcctg tcttaactcc 22801 ccagctaggt aataattttc ctgaaatcag ggaccaggct gactcctctt gctgtctcaa 22861 gaaagcttag cagtttccaa cacaaaaatg ttcaataaac aactattaat tgactgatta 22921 taaaaaatca gtgaaccatt aaacttaata tagcaatttg cttagcatgg taattagctt 22981 tttgctaata ttcttccagc cagtctctcc tcctgtgcct caaggacatc ttaaaaaaaa 23041 aaaatctagt tgatctgctt ccatctagtg gcaattaaaa caggtggttc cggtagccag 23101 aaaacagctc tgggtagatt gtgccagaaa atactttcac tcagtaggtg cgagtttgaa 23161 agaaatcttc acatctgtgg gtttcctgcc acagacatag ggagaccagc ccagagaaag 23221 aagcctttcc tcactagact ccatttgcac tagtaaagag aagacagagt aattaaaaag 23281 aataaaaaga acctccactg atcgtacatc ctcatccagt tacccctgcc ccacttctcc 23341 ttcacagcca aacattttaa aagagatgac tgcttgttct gtctctactt tctcatcctc 23401 agtaatgctc aatgcttggc cgtctgacct ctgtcttgat gtctgcactg caaatagtct 23461 ccccactgac acccttgttg catccagggg atacttactg gttctcttgg caatgtttga 23521 aaccgttccc ctttctttgt ttccttggca ttcattaccc cacactcttt ctcctcttc 23581 ttctccctgc ctggcaacat cttttcattt ctctttccct taggtgactt attagataat 23641 gatgttcctc tggctcccat actctctccc aggtcctctt ccattcttaa agcactcaca 23701 ccctccctgg atgatagtac ccactcctga gatggcagtt acctcctgaa atgtgaggga 23761 cccaaatcca cttctcctgc catagcctct gtgctttgga taggtccaat gagccacagt 23821 gaatgatgtg catacaccca aagctcagta caaaactgaa cccatgatct ttacctccaa 23881 aacctctcat tcttttatgt tcccttctca gaagtaaaca ggactaccat ccgccagttt 23941 ccaggtgaga aagatgataa tttgattctt ctctctcact tttagccaat taacagacac 24001 attcagttaa tatcacctcc tcttatttca tgaacccatt cttactacta gttccctaga 24061 caggcgccat cggttttaat ctaataactg caaatgcctc caaaacaagt ctctttgaat 24121 ccaggctcac ctgtctccca cacttgccat actgctctgc agggtgacct tataagatgc 24181 cagaggtaag gctactcact gtttaaaccc ctttagtgat atcccaaaag acctcaagat 24241 aaagcccata tcacatggct tatacattag tttatgatct ggcttctggt gcctcatttt 24301 tccccacttt ttcctttgca ttctaagcaa tggcccatac taagtttgtg attggtagga 24361 tggttgccca aaccagcatc caatcccttc agaaatcatc tcacttcatt tctagcattt 24421 taaaggaagc tcagttgtcc agctgggtac tgaatatgtc accaaagtcc tcctttcata 24481 gtttatttta cttaaactct ccttcctaaa attccagagc aagtcactaa accctagata 24541 ctgagaaata tttttccatc ttcatttctg ccaggtgggc catcaacttt cacatgtctg 24601 catctcctcc cactgtgcta tttctccagt agaagaaatt tgagcttcaa gaccaaactg 24661 aaaaatactt gcctccttgg ggaagctgta ggtagaattc atgctcccta tctttcccac 24721 atttctgaag gacaatgcct gttagagcaa ttgaatgcaa atagtcaatt gaataagcat 24781 ttattcattt ctcaataagt gcttgttcaa ttgaatattt cttaaataat atatttaaga 24841 acaagaagaa cacaccacaa tgtttttaac cctcagaaaa aattctgagg taatcagaaa 24901 aatctccctt tacataaact gcccttttct aatagggatt acttgttcgt tcattcattc 24961 attcagctcc actagcacca aaaagcacag ctctgaaagg aagctagtag atttatcacc 25021 ttatctggtc atttggatga ggaccccagg taaataaact actatggggt taatgtgtct 25081 agctagagca ggaagtaact taaggaagta gagaatgaat cagcagatgt ggaaactcct 25141 cgccactaat aaaacttacc ttctcttgga tttcttgcct gaaaatagaa aatagagaaa 25201 aggcattagc aaaaattaga caatttaaag tttttcaagt aagggagaag gaagactccc 25261 actctcaaaa ctgtcttttg aagtatatta ggtatttgtt aggtggaccc tatctgtgtc 25321 aaaggagatt tgaggaactg gcttaataaa cagtggtaqa cactaataca gaacagacat 25381 gttgatgcag atgcctcctg aggttccatt ccattctccg tgctactcaa gaagacagaa 25441 ttgctaaatt gcctggtggc aagacccaat atgtccattc aagtgtttat cccttcccaa WO 00/09525 PCTIUS99/17712 EPI-109 978 25501 tctgccatct catcctaczt gcagattctt cccttgaggg acagctgcta atactgtaaa 25561 actatgtgcc attacagctc acagcatcat ctctatgaga atccacaaga gaatttcact 25621 ttggtcttgt tggtaggaat tgtgcagcct catctgagta actaatgtgt ttttatctta 25681 caaacacaag gaatatcaca tggttctcct ttgactggct gtaaggaaac tcagagctag 25741 atctgagacc ctctcctacc aagtatataa aactttgtga catacatttt tgtgccataa 25801 cttcaacctt ggttccaaat gatttttgta ccctaagttt aaatttggct ttcttttttt 25861 tttttttgta ctcaataaaa catcaagctc atttattatt gcgaagagcg aaacaacaaa 25921 gcttccacag cgtggaaggg gacccgagtg ggttgcccaa attggcttct ttttcttact 25981 ttttaattaa ttttaatttg ctatactgaa cacattttgt actgttctca cattcttttt 26041 gaaaaaagca gaatataaat aagtagataa cttaaaaaaa actctttgag cagaaagaat 26101 catttgggag gcaatatatt tcagtggctg taaagtggca ttctagaatc atcctaccca 26161 ggtgaaagcc ctattttgcc acctgtagtg tagtgtgtat ttgaacagct actttctttt 26221 ctaaactaca atttcttcat ctgttaaaga ggcataataa ttgtatcatc ctcattgggt 26281 tgataaaata aaatatttcc aagtatttag ttcaggtcct agcacgtaga cagtgttgca 26341 ttactgtttt aatcctttaa agtattaaag actactattt gaaatctttt cttctaaaat 26401 tcagcctgct gatgaccaag tgcacttgag cagggggaat caaatctgaa ttaatttcag 26461 attctggtta gcttcacata aatatttttt ttagggatga tgaacctaac agcaatagat 26521 gagtaagaat ctgttcctac tgagagagtt tcattttgaa gaaaaaggaa ctaagggggc 26581 atgtgttcag tttcatgccc tggtctaacc ctgtgtgttg gttctggtgg gaaattcttc 26641 caaccgagga aaaaaccagt tcacaaatct gaagaccagt gattttagaa gatgtatctg 26701 gactggagtc taatctctga ctctgggtcc tgctgatatg gtatttttga gatttggcct 26761 aaaacatcat tgccctggtt tccttattta ccaaacaggg ccaatggtag tgactaatca 26821 gaaaatgata atgcctggtg cacaaaatgt gtctagatga gcccatgcac aaggacacat 26881 gtttctggaa ctgttcctta ttcctttcct aaaagaaagg agggaaagtc tccatactaa 26941 gactactagg gcaggggaca aagtgctaga gtcagaagat tcatctgagg acagaagaat 27001 aggggtgaag gctctagtca cttcattggc taccatgctc taaatagtta cctgtgccct 27061 ttttctaact attagaaccc aaaaagccta taaattctct ctctctctct ctctctctct 27121 gtgtatatat atacatatac acacacacat agacacacac acacacctaa acacacacat 27181 agagatttat gactttttac ttttatcctt gtaaatgcca ttaactatat tttgtcttag 27241 atttagcctg ggaatgtagc cattatttct accattgcct ccataggaaa aatactcttc 27301 atgttttaaa ggaccaacct acaactaaaa tctttggaaa gcagaatcat ttgtaagttg 27361 gtgaaaatgg aagatgttgt tttataaatg aagacttttt tttttttttt ttttgagaca 27421 gggcctcact ctgttgtgga gtgcagtggt gctgtcatgg cttactgcag ccttgacctc 27481 ctgggttcaa gtgatcctcc cacctcagtc tcctgggtag ctgggactac atgtgcatgc 27541 taccatgcct gactaatttt ttgtattttt gtagagatgt ggtttcgcca tgttgcccag 27601 gctggtcttg aactcgtggg ctcaagtaat cctcctgcct cagcctccaa aagtgctggg 27661 attagaggtg acagccaagg tgcctggccc acagatgaag actatttaat gttatcttaa 27721 agatacccta agcttcctac caagccagtg atcttttggg gcttCtgttt tctttgttgg 27781 cataactgta actagcctaa ctgcccgtta tctgtttcct gtttgcccca cactgattcc 27841 cacagcagtt ttcaagttat cggtttgaga tcttgtacag aaatgactcc aaggtaaaaa 27901 atttaaaaac aacccctcta atttttttac ccttgcttat aaaacagcct tagccagcta 27961 acccctcact acatgcaaat gagtttgatt ctattctttt gattctacaa acacttatta 28021 aaagatttta gaattcggaa ataaatagct tccttattaa ggtgacttac agccccaaag 28081 tccttaaaat tatttagaca atagccacct tatcccaggg ggcagtgtgt aataacccac 28141 cctgttctct atccgtcagt tctgccatca tcgcccaagg taggaagaaa gacaggacaa 28201 ccggggtcaa gatttgaagt ctcaatggaa agaataatca gtggttggag aaaactgtca 28261 ttcttctttt gccttaatgc agtacttgat acttatactt agtactgtat agtacttagt 28321 actgtataat actataagat agtgagattc aatcagcaca gaatttctaa tagcaagggc 28381 agagacattt taactgctca gtgctctcag gttatacata gctaatgaag ttcttgcata 28441 tcaacaatcc ccacccccct cacacacttt gtctttctgg attggttaga aaacttacct 28501 agcgcccact attctcaaat ttaaatgaaa gataagatca gagtggcacg caattaggga 28561 ctgataaata atatttttgt aattgccagt gtaaatggac agggggcaac ctttacatac 28621 catattcagt gaacagaata cgtactaact aatttgatgg aaggaaaatt aaaatgacaa 28681 tcaactgagc ccacagaaag gcaacacaga gcagttggtt agcaattgtt tcgagatcat 28741 ccctgaactt gaaacaggta tatctttttt tttttttttt ttgagacaga gtctcactct 28801 gtcaccaggc tggagtgcaa tggtgcggtc tcagctcact gcaacctccg cctcccgggt 28861 tcaagtgatt cttctgtctc agcctcccga gtagctggga ttacaggtgc ccgccaccac 28921 gcctggctaa tttttgtatt tttagtagag acagggtttc accatgttgg ccaggctggt 28981 cttgaactgc tgagctcatg atccgcccgc ctcggcctcc caaagtgctg ggattacagg 29041 catgagccac cacacctggc caaaacaggt atatcttaaa agctgcccaa tgtccatgaa 29101 tgttacagcc ttgaatggtt cttccaggtg agtttggcca aatgtggcac catacaccca 29161 aggcctgctg caggctagtg ggttgctcac actttaaagc tgagacacac tcatgcctta 29221 aggtaaaggg agtgataatc tgggcagcag atgttaactt ctcaaggcag tcctccttct 29281 cttttcctct ccagtgacgg atggttggaa agcatatatg gtgcatttgg ttagagctgt 29341 ggccttggtg aatagatact tgggagaata catgggaatt tctcccaggg ttaatgcaat 29401 gcccatgtgt tgggaaccag gtgactcttg aagaggtcag gtatttggga qcagtgcctt 29461 gaaaccttag iggacattag acccacttcc tagtggaatt gtagcattga aatccaaggc 29521 atgtaggctc ttagaggaca gagatagtgt gtcatttttt cagaattaat taagagcagg 29581 ccaggcgtgg tggctcacac ctgtaatcca agccctttgg gaggccaagg caggcagatc 29641 acgaggtcag gagatcgaga ccactctggc taacacagtg aaaccccgtg tctactaaaa 29701 atacaaaaaa ttagctgggc atggtggcac gctcctgtag tcccagctac ttgggaggct 29761 gaggtgggag aatagcttga acccagaagg cggaggttgc agtgagctga aattgcacca 29821 ctgcactcta gcctggtgac agagtgaggc tctgtctcaa aaaaaaaaaa gtattaaaga 29881 attacataag agcaaagaac cattagaata tctcacttag ttgttatcag cctagcaagc 29941 tgccttgaag gtaatagaca tttttaaaag tttatcagat gaaaagcgaa aatcagccaa WO 00/09525 PCTIUS99/17712 EPI-109 979 30001 cctgttttaa tgaaggtgtg tcctgggctg atttacatgt ctccagggac tgatggctct 30061 agaatgtaaa gcttggcatc ctgcttgtgt tgaatctatc acatttaatt tcctgtgggt 30121 ttcttttttt tttctttttc actttaaagt tgtgttcttt tcatgtgaag ttaaactcac 30181 ataccttttt ttaatctcct tgccagccaa atgataaatg ccaacccaga gaatgcagta 30241 accatgactg ccactggaat gaagaggggg ttataatcac cctccttaat cattgagaaa 30301 cttttgtcca attctgaaag agaaatcagt aaggcacata gcatgagacc accagcatta 30361 tttccttagt ctatctcatg atatttgact tttttcctcc ttacatctcc cagtagtagc 30421 ccatttgatg ccatttgaca gatgaggaaa ctggcatggg aaggcccctg atgagtctac 30481 agcataggca aagactggac cagccttgct agtctaatgc ctacagaatc tcaatgccca 30541 gatttgtggt tcatagagtt cctgaaaatg cacctaaaaa tgttggcaag aatggtcatc 30601 gttgtattta gctccatgga cttgttcaat gactggaact ctgaaacaca gagaagagct 30661 aaaagcctaa tacaacttca ggaaaaataa aagccaatga tctgaactgg ataattcacc 30721 agtcaaagga aatcattaat gcttttactt taaagcagtt gtgcaaaaat aagcacttga 30781 tttttacatg ccaaggacct gcactaattt ctttccaatg cagtagttac cacttccctc 30841 tacttccttc acgaataagt aaaagggcat gtttagagat actcttgtaa gtgtaaacta 30901 agttcatttg ggagcctcta tttgaaaata ctggtataaa aaaaaatctg tctcctgata 30961 ctaacatttg aaggaatcta cttttttaca tattggcaga gggtctgatt ctatccttag 31021 ttcttcccat tactttgatg aaccttttca aggtgatttg atccccacac ccaaatatat 31081 gattgagaga aggctcaagt tcccaggagc tccagacaga aggtacctgt tggcttgatg 31141 aagatgagga ggaaatgaac actagctagg ccttaaaggg aaatgtctct gataggccta 31201 atacacagtc ctctgctaaa ggcctccctg cctctctctg ctcatccact ctactccctg 31261 gccctgggca cgcagcacac agagatcagc atttctgaca gcttctgtag atcctaccat 31321 ttaaagactt ttgtcatcca tgcagatagt ctcaggagca gacacaggta gctattcttt 31381 cacatgctag cttaacatgc atttgcttta gcacctattg ccaggcactg tgtcaggtgg 31441 agggtataca aagatgaaca agacatgatt cttctcatat acagatagat tttggaggca 31501 ttagcttagt gatgattcag gagtatccat tatttgggga agtaggtggt cattagtgac 31561 cttttacagg catttcaatg ggctaacaga gatgttagat tgtagtggaa tagaagaatg 31621 ggtaaaaagt aaatcagtga gttcagattt taggagttaa gatggcaaga ggtgagaaca 31681 aaaaaaggaa atgattgtca ttaaaggagg aggaaagacc agccaaagat tttacagtga 31741 gttaagcata caaatttatt tctaggccac atattcttag caaaacaaca tgtaaatgtt 31801 tatgtatgtc tttcctcata tctgctcatc catcagctcc atcgttaaga tttcagtttt 31861 ccaggacaaa cttactcact ttgacatatt ggactaggat ttgaccagat tccagatgat 31921 tcacaaatgg ttttcttctt cccaattaac tcagttcctt ctgagcagat gaaggtacat 31981 gcagaggtaa agctgaagct ggccagggga tggctacagt tcatgatccc caaatctggt 32041 gctgatagag gctcacactg aatcacttca atgaaaaaga aaaaaaaaaa aaagacaaaa 32101 cagtatttct gagtagagac cctcccttga gcaaaggatt tttagccaaa gctgcctgac 32161 tacattactt gtgatattgc ttccaggctt tattttcttg agaatgatgg tgggtggtga 32221 atgagagatg aaggcaagga agcattgaaa gctgtgggga gaggagtagc tactccaggc 32281 tgctgcccta gctaaggtga ccctcccctt ctgctggaag taccatgcca tatggcctct 32341 gcatcaaggg ctcttatggg atattctcag agaatctctg ccgtttcatc tgttctgata 32401 tctacccaag cattttgaaa aacatcccaa ttcactgaag caagtccaac ttccgtaaat 32461 tccagtaggt gggttgacag ttttataatt tcaataaggg attttgatag cacttctaag 32521 aattaaacta cttaaactaa tgcatcagga gcatacttgt agaaaagtta accaaaactt 32581 cgtaagttca gatgacattg gttttctccc atatggagat aaggttggca gttaaaaatg 32641 aaaaaaaaaa aaaaacctac cttatttcaa acttgaaaag atcaagagat tgtgtttttg 32701 tttttcagtt gttattctcc taaaagttta tgcatgagga aaagtaaaag tgattttaag 32761 aataagccaa ataaaacaac caagaaagac ctccactacc ctgggaagga aactggttgg 32821 tattaagtag gacaccacat aaaacaqgtg ttattgagag gagaagaacc aaaatgtaac 32881 tgaggttcaa caagacatta tttatgcaat ggcaatgaga aaaataaaaa acacagtata 32941 accatgctgt attgctataa gtcatgttac acactgggag atggcttcag gggtatttgg 33001 tttttacttt ttgtttggga ggtttttcaa aaaaatttag ttagaataag tcctttgaga 33061 aacatcacag taggttaaac aaagttaggt taaattaggc tcctaagttt gacttctcag 33121 caaacttcta ctgaatgttc tgactgtaag cccaggattg catgacaaaa cctctagtct 33181 gaagttactc accttgacag gttggttctg gagatgacca gtttccaaat ggtccacagg 33241 tggtttcttc aatcccagtt aagtttgttc cttcagagca gctgaaggca cactgtgagc 33301 tgaagctgaa gtttcccaaa gggtgagtac agtccatggt acccagctct ggggcctcca 33361 aaggctcaca ctgaatcact tcaataggga aagaaacagt atggggaaga gttaagagga 33421 actgacgcct ggatttgaat cctagccctg ccacttgata accatgtgcc tttaaacaag 33481 gttacttgaa ccctccaact tcagtttctt catctatata agaggaataa tgaaattgtg 33541 ttatctttat caaattgata tggaaactaa atgtaattca attagcataa gtcaaggacc 33601 ttagaacaaa gcctgactca tcagaaattc taagtaaaca ttagctagtc ttcatattat 33661 tatcttcagc attatctgta gtgagaatcc ttaaagccaa ataggtgtaa ctgggaatga 33721 ccagcttagt cgggaaataa ctatcacatc agagcccctg agtctactag agtattggga 33781 gcaagatgtt cagagaaaga gtgggtctcc ataataagcc ttctttgcaa ggagagaata 33841 taaaagtcta ggaagcattt tgacctcaat tctgtcttct attctagctc agttccagaa 33901 ttttaactct tttgattttg acaaccctct ccagaaactg tatctatttc cctgttctga 33961 ttggtggtac aataggtaaa tttaagactt ggaaatcaaa gttttcacat tttagaccct 34021 gccatgccat ttagtaaaca gtacaacttt catgtcttat tcctcatctg tcaaatttaa 34081 gccattattg ctaccttgct ctagagactt caaggaagaa tggactcaag gaatcagaag 34141 aatttttgta tttggaaact atatgagatg agattaggga gaaacatggg aactaagaga 34201 aaatgttatc ttttttcatt gatttaaaga gtatctatta tatatcaagc attactctgg 34261 ggcttgaaga gcttagattt caccctgtag gacaaaatgg taggtagaaa ttaatgggtg 34321 gattgtcatg tatgtgtgat gtgttttaat tgcttttaat tgatcagtct ccctgtagta 34381 tgaataatgt atttgagggg agctaattta aaattgtgga actcatctaa taaactattg 34441 caagaatcta gaagaaagat aatgacggca atggtagtag agttgacaag tggaagacaa WO 00/09525 PCT/US99/17712 EPI-109 980 34501 attagaaaaa cactaagttg taaaaattgg tagaatgtta ccctgcataa atgttggggg 34561 agttaagaga gtctcatacc agggtgccca tgtaaatggt gattccacat actgagataa 34621 gaaatacgaa gagaaaagct gactgggaac aattggtttt atagtctttt aaacatccca 34681 aaggacatcc ttagcatatt tgagttcaga gctggagata ggcttatcag tccaaagatc 34741 acatagattt gtgagtccgc aaaagtcagt aagtttgacc aaaggataca tgtagattag 34801 agtcagaaga gcaatataca aaagacaaaa gctgagaaat tatagtagtt tatggtcctg 34861 gataagtgct catgaaggat ctcaggagaa atgatcacag gtagaaagaa tgagaaaaga 34921 gtgatatgag agaaaccaag acaaagaaaa gtaaaatgtt aaaaatgagt gaaataggca 34981 taccaataat taaaaatgag taaaataggc ataccaataa cataagggtt aaaaaataga 35041 gttcaaaaat ggggtgaggg taaagtatta ggaaggagtc atggcccagg gatcaagtga 35101 aatgagttag atctatagat ctatttcagt tggttgacat ttaaatgtat tttggtttta 35161 attctttatt gtttacaaac attgcttttt taaaaaatta aattgtccaa ttcaattcag 35221 gctcacaagc aagtgcctca tatatacagg cattttgtgg atcccaaaga tgcaatgata 35281 aataggacac ttactgatct caagaagttt tcagtaccag aggagacgga caagtgaaca 35341 gatgacttca acataagtgg gagaaatgag gaagaaatat gtggagctat cagaactaag 35401 aaagcttcct agaagaaact gtctttgaac aatgtcttaa agatgacatg ttttttggcc 35461 atgtgcaaaa tgagagagaa ggccaccagc aaagtcagtg tgctacagag cacatgtgtt 35521 aagtgtggag aactgcaaga aggaaaggaa ctactagaag gaaaaagcaa gatactttct 35581 gggtaactca gcctcctaat gataaatggc atagtttctt ccagacctta gagttctaat 35641 taatctaaca agctcattag atcgtgagct tcttgagagc gggaatctac catgctaatt 35701 ccttatggta accctgacag cttttatccc aacactgtgc ttcttgtggt actcaaaaag 35761 acttgttgag aagtgagtcg aaacttcatg ctgacttatg aaatctttac ggaaaggtaa 35821 caatattgtg aaagcagagc tttctgatca aaacttccca tttctcagag tggctagtat 35881 cattttgttc caaccagctt catgataagc tataatgatt cctgtgactt tacctaagaa 35941 gaagcaaaga aaggaaagag acttaccaaa ctgacactgg ggcccatagt accccacatc 36001 acagttgcag gtgtaattat tgatgatttc tacacattct ccatggccac tgcatgacca 36061 gggctggcaa gaagctttaa ggaggtcaga aaaaaaatat tttaatgtga ttacatttta 36121 gtactcaaag tcatttcttt agacatagat aaccttttgt ctgagatgat ttaaataatc 36181 aggaaaggtt tatttgtaaa ttcatagcat aaaaatcata tgctaaaatt tttacgtata 36241 aaatacacta agcatatagt cataggcatt tatttgcttt tggaatgaaa ttaccaatac 36301 taatattctg taacacttat aggaaactta gtggcatacc ttgaaactct tgaaattact 36361 tgtttttaat gagtgagaag gttaaatgat gacctgacct caatcatttc tgcatgcaat 36421 tatttcttgg caatcccttt ctttatagaa atcaaagatt aaaaagtcca aatttgctaa 36481 aacggtagag tccaatttat aagagaccaa attaactatg gttcattatt aaaacatcac 36541 ttggaaaatg ctggctgttt tggaattgta gaagatttta cagaaatatt catacaccaa 36601 agatagtgca atttttatat aaaattatat aaggttagac caagaaggaa gcacgcagca 36661 ccacactctc tacttcacaa tgtgaaaact gaggtgatgt gagcctaagt ttccaactgg 36721 ccccagctgt cagcttctcc tcccctgcct tattatcaaa ggcactgatt gtctagctct 36781 tcctctgtac ttcctacgta gatctatcat tttgatgtaa cttgatttag gggtatagct 36841 tttgtgcaca gggacaaatc ttacacacca aaaattctta ggagtgacac gatgcaagat 36901 tatatagagg gctagatgta ttttagaatg aaccagaagc tgttctcatc cccccacctt 36961 tccatggggt aaatctgagt attctcttaa ccgtggccct tcctgagtct gaggcagcat 37021 agccgtcttg tcactcccta cctgtgtaac agagggctgc ctttagtttg tggcaggcgt 37081 catcgttcca tttgcctgca tctttgtttc tcttgatata gatctccacg cagtcctcct 37141 tgttcttctt gttgttgggc tcaccatctc cccagttctc tgcttcttca gtaagagatt 37201 tgttggttcc cacccacgtc catattcctc ctatcttccg gattcctatc cagtagtaag 37261 aacgactgaa aggcagagtc ttctccagat actcaatttc cgccttgttt tgtatggcaa 37321 ctaaatctgt gtaattgtct cggcagaatc ttctagccct ttgccagttc atgggttttt 37381 cagaataatg gtaagtccag cagtcggttc catgatgtgc caggaaatct gcaagacatc 37441 agtgtgacct atgcagactt acataatgtt acagctaaaa agaacctagc actactccag 37501 gctgagctag acacttagag atgaggaaac agagcctaag agtgtatgtg accatctcag 37561 gatcacagaa tagttgtttg cagatttgaa gtagaaccta gaccttctgg cttgaatata 37621 agatgctttt atctaaggtt ctatttgaaa caaatttagt ggttttctag gtttattttc 37681 ttattaattt ttttctcaaa attatttcag gtgaaattta accaacatat tttagacatt 37741 catatttctt tttctttgta gctgttaatg atttacaact aattaccgtg taatatcata 37801 taactataca atttacgtat actttttaat cctggaatca tttcttgaag gccaacacat 37861 atgtacctat gggagaagca taataaggac aggaagaaca gtgacatact tttaagtaac 37921 ctcttttaca taaaaaacat tttattttac cataggaaga actgcttctg gaaaagccca 37981 atataccact caactcttat atatctaact gtataatttt taaaaagaac aatttacaaa 38041 gccaaatggt ataggattat gaaattcatt agatcatgtt ctatacacaa agagactcaa 38101 ctgatgatgt ttaataaaca tatggaccca tcaaatatga gggctttgaa gatatctaat 38161 taaacacata attacacaat gacttcataa taatatatgg cattctaagc atggtatgat 38221 ctacatgaat cactatttaa tacagtaaag aaacagatat aattgatggt aaagagcatc 38281 ataaaataaa cattttgaac agagttttga atgagcattc cactagaatg caagttctaa 38341 gagggaaaaa actgttgtgt ccactgctgt atccttagtg cctagcataa atttcacaca 38401 ttgtagggac tcagaaaata cctgttgtat gaaaagagca ctaagtttct atgtgacaca 38461 gtgcagacat ggcataagga atgtgtgaac gggagagtta gcatgtttgc ttggctagag 38521 ctgaaaatcc aggctaggga gaaagaagac attagtttac ttaggaaatg aaaaaccaag 38581 ttcaaagcta ttgctggaga gtcttcaaga atcagatata aaatttgtca caacaatggg 38641 agaaggacca aaaaatgata aacccccgtc ccttaataag ctcgtattgt aattgtagaa 38701 atgacattaa tgtacactga actatgaata aaaaatagaa aatgaggtgc taaatatttg 38761 gtacagattg taagtacctt aacagagatt tcttaattaa cattattcct ttataattga 38821 gggattttgt ggggttattg ggatttgaac tctacagcat gggctattat aggttaaaaa 38881 tagtgttcag gagtttctgg ggaagaacta aaggtaagaa gaaaagagat gtttacagaa 38941 gggatagaat taacagctct gtgaaataat tttcccttag actatgtata actagtggat WO 00/09525 PCTIUS99/17712 EPI-109 981 39001 atttaagaaa aatgaatata agtaaaatag acttagcgat atataaatat cataacatac 39061 cacaacagag cattgtccac ccccacaact tgaagatgtt ccataagtcc ctctgggtgc 39121 tctgacattt ccatggaaat atctgcaaat gaaatacaaa attatattta gatgtatact 39181 cttaaaccac acatttatag cctttgaggt ggtgcttaca actttcttaa taatcagaat 39241 aaaacacata tgtctactaa ccctgtctga ggtaacaggt ttctcagaca tagatgaaaa 39301 attacttcaa atttacatca gaactgatgc acagttttgt tttgttctat tttattttta 39361 cgctttagtc tcaagttgct aatcggtact gccctgaatt ttttctatgg tttggtaatt 39421 tttatacctg cttttctgct gagctattag ataaaactat ttaatattta ctatgtatat 39481 tttttaaagt attgttgctg cttaattaac tattgatgct tatatttaat gttatagcct 39541 cactcttgat cataatgggt caatgcctca aatacctaaa aaaaaaaaaa attagatagc 39601 cagacaccag gaaagaaaag tatttctttt tttaataaaa agaaatacct ttttgagcaa 39661 ctgaaatgac aaagtcacaa atttcctgca caccttaaaa tatacttaat gtaaatgacg 39721 agttaatggg tgcagcacac caacatggca catgtataca tgtgtgacaa acctgtatgt 39781 tgtgcacatg taccctagaa cttaaagtat aattttaaaa aaattctatc ttccaaagca 39841 tatcacttct caggtagaca cagtgtttat tgcaaaagat ctgatttcaa tagtatttct 39901 tcaagagtct ccccagagac aaagtcaaga agaggaaatc agcatatctg agaagaaaga 39961 tttcaggatc actttttttg agggtctgag aaaatgttta gtttctatat tatttaaaac 40021 cagaattgaa atggggtgat tcctatcctt gccacctcc tctacaaccc caagagtttc 40081 tatctgagca tctaaacgtc ttttaggctg aaaggctcac catggctttg cttggtcctt 40141 ctctagttct tctgcagccc attgagcctc ttgacttagc acaagggtct caggtccttg 40201 cccaaaggga gtgtgctgtg ctgcaggtag actgcactga atgtcaacag aaagccttgc 40261 tttctttcat ttctctaacc cagtctcaca tcctcctcct cctccccttt tccctcccct 40321 tcctcctgca cttctctttc ctctttcccc acccctttcc tagactggcc tctattgcct 40381 cccactgaga caaaaatgaa ctgctgatca gaaagtaatg tgactagatt ctctcttcct 40441 tccctccttt ctatccttcc ttccattctc ctatgcatct ttccttaccc tcctcctcct 40501 tcactcattg ttgttgctgt tcttcttcct cttctttttc ctcctgctcc tcttcttcta 40561 cttgttcttg ttcttgtttt tgtttggttc ttgttctcct cttcctcctt ctctctctcc 40621 tcctcctcct tcttttccac caccctcccc tatctttttc ataaatgcta aactaactct 40681 tggctacctg tggtaaatgg cccttggaaa ttgcaaatac tacaaatcaa aactgcattt 40741 cagacatatt tatgatgttt gcaaaacttc agtagagcta agcagtggac ttgactcgtt 40801 tcggttcctt cacctccgtc tttccttgct caccacctag tggacgtcct tgttagtggc 40861 acttcctgaa gttaacccct gaagagagcc catgctctct agcttttcac cgtgtaggtt 40921 tgggagccta caagtacctt taatattctt ggactataaa atgagatggt tttataagac 40981 tgcatgtgaa attaggaccc atatgatgaa ggacaataaa aaggaagacc cactgatgtg 41041 agtcaatgag tcaaatgcaa atcagatttg catttttagg aaaataataa taacaacaac 41101 aaaaactctg aagctcagcg ccccatattt attatattgt ttaatcttta taacagctct 41161 ctgctataga tatgattatt atccccattc taaagagtct caaagaggtt aagaaacaaa 41221 ttcaaaaact agcgaaagac aagaaataac taagatcaga gcagaaccat aggaggtaga 41281 gacacgaaaa agccttcaaa aaatcaataa atccaggagc tgcattttga aaagattaac 41341 aaaatagatg gaccactagc tagactaata agaaagaaga atcaatagac acaataaaaa 41401 atggtaaagg ggatattacc actgatcccg tagaaataca aactaccatc agagattact 41461 ataaacatct ttacacaaat aaactagaaa atctagaaga aatggataaa ttcctggaca 41521 catacaccct cccaagacta aaccaggaag aagtcaaatc cctgaataga ctaataacaa 41581 gttctgaaat taaggcagca attaatagcc taccaactaa aaaaagccca ggaccagatg 41641 gattcacagc caaattctac cagaggtaca aagaggtgct ggtaccattc cttctgaaac 41701 tattccagag aatagaaaaa gaggaactcc tccctcactc attttatgag gccagcatca 41761 tcctgatact aaaacctggc agagacacaa caaaaaaaga aaatttcagg ccaatatccc 41821 tgatgaacat cattgcgaaa atactcaata aaatacggca aactgaatcc agcagcacat 41881 caaaaagctt atcaaccaca atcaagttgg cttcatccct ggaatgcaag gctggttcaa 41941 catacacaaa tcaataaaca gaatccatta cgtaaacaga accaatcaca aaaaccacgt 42001 gattatctca atagatgcag aaaaggcctt ggataaaatt caacacccct tcatgctaaa 42061 aactctcaat aaactaggta ttgatggaac gtatctcaaa ataataagag ctatttatga 42121 caaacccaca gccaatagca tactgaatgg gcaaaaactg aaagcgttcc ctttaaaaac 42181 tggcacaaga caagtatgcc tctctcacca ctcctgttca acatagtatt ggaagttctg 42241 gccagggcaa tcaggcaaga gaaagaaata aagtgtattc aaatagaaga gaggaagtca 42301 aattgtgtct gtttgcagat gacatgattg tatatttaga aaatcccatt gtctcagccc 42361 aaaatctcct taaactgatc agcaacttca gcaaagtctc aggttacaaa atcaatgtga 42421 aaaaatcaca agaattccta tacagcaata atagacaaac agagagccaa atcatgagtg 42481 aactcccatt cacgattgct acaaagagaa taaaatacct aggaatccaa cttacaagga 42541 atgtgaagga cctattcaag gagaactaca aaccactgct caaggaaata agagaggaca 42601 caaatgaatg gaaaaacatt ccatgctcat gggtaggaag aatcaatatc atgaaaatga 42661 ccatactgcc caaggtaatt tatagattca gtgctatccc catcaagcta ctactgactt 42721 ttttcacaga attagaaaaa aactacttta aatttcatat ggaaccaaaa aagagcttgt 42781 atagccaaga caatcctaag caaaaagaac aaagctggag gcatcatgct acctgacttc 42841 aaactatact acaaggctat agtaaccaaa acagcatggt gctggtacaa aaacagatat 42901 atggaccaac ggaacagaac agaggcatca gaaataacac cacacatcta caaccatctg 42961 atctttgaca aagctgacaa aaagaagcaa ttgggaaagg attccccatt taataaatga 43021 tgttgggaaa actggctagc catatgcaga aaactgaaac tggatccctt ccttacacct 43081 tatataaaaa ttaactcaag atggattaaa gacttaaatg gaagacctaa aaccataaaa 43141 attctaggag aaaacctagg caataccatt caggacgtag gtatgggcaa agacttcatg 43201 actaaaacac caaaagcaac agcaacaaaa gccaaaattg acaaatggga tctaattaaa 43261 ctaaagagct tctgcacagt agaaaaaaaa aaactatcat caaagtgaac aggaaaccta 43321 cagaatggga gaaaattttt gcaatctatt cacctgacaa agggctaata tccaaaatct 43381 acaagaaact taaacaaatt tacaagaaaa aacaaacaac accatcaaaa agtgagtgaa 43441 ggatatgaac agatgcttct caaaagaaga agtttatgca gtcaacaaac atatgaaaaa WO 00/09525 PCTIUS99/17712 EPI-109 982 43501 aagctcatca tcactggtca ttagagaaat gcaaatcaaa accacaatga gatgccatct 43561 catgccagtt agaatggcga ttattaaaaa gtcaggaaac aacagatgct ggagaggatg 43621 tggagaaata agaatgcttt ttacagtgtt ggtggaagtg taaattagtt caatcattgt 43681 ggaagacaat gtggcgattt ctcaaggatc tataactaga aaaaccattt gacccagcaa 43741 tcccattact gggtatatac ccaaaggatt ataaatcatt ctacgataaa gacacatgca 43801 cacttatgtt tattgaggca ctattcacaa cagcaaagag ttggaaccaa cccaaatgcc 43861 caccaatgat aaactggata aagatgatgt ggcacatata catcatggaa tactatacag 43921 ccataaaaaa ggatgagttc atgtcctttg cagggacatg gatgaagctg gaaaccgtca 43981 ttctcagcaa actaacactg gaacagaaaa ccaaacatta cccattctca ctcataagtg 44041 ggagttgaac aatgagaaca catggacaca gggaggggaa catcacacac tggggcatgt 44101 caggggatgt ggggctaggg gaggaacagc attaggagaa atacctaatg tagatgacag 44161 gttgatgaat gcagcaaacc accatggcac atgtatacct atgtaacaaa cctgcacgtt 44221 ctgctcatgt atcccagaaa ttaaagtata atttaaaaaa agtttaaaaa aagaaagttg 44281 ccttagtcac ataactagta agagacatgg ttgggaattt gaacagaggc caatcagttc 44341 caaatccatg ctcttgatca ttaagctgaa cttatggcag gaacttggaa gacatggtaa 44401 aatggggaaa aacgtggagc cagggagact tgtgaaagtg ccagtgctcc cactataccc 44461 tgaaagaagt atctagactt acttttttct aagtcctctc ctctaattct ctcaatctct 44521 ctctctcttt ctctaagaga tgggaatgct gctctgtcac tcaggctaga gtgcagtggt 44581 gcgatcatag ctcattgcac tcaaggaatc ctagggtcta gtgccccttc tccctcagcc 44641 tcccatgtag ctaagactac aggcacatgc cccaaccctc gactaatttt tttatttttt 44701 atttttgtag agacaggatc tcactatgtt gctcaggctg taattctgtc ttgaagcttg 44761 tccaatcagg ctttcagcca caccaattcc ctgagactgc tctcaccaag gtcctacact 44821 tcactaacac aaacagccta ttctccatcc tcatcttact tcaccaggga gctcctggtt 44881 ttcctcctac ttcactggct atttcttctg tatcatgtgt tgattctccc tcatctcccc 44941 aacctccaaa cccttggagt actccagaga tcaccgcttt gctcttctgt gtctaacctc 45001 actaacttgg tggtccaatt cacactcttg actttgaata ccatttaaat gcgaacgaat 45061 tctaaattct gtacaaccag aaccattctc ctgtagccaa atgcctactc aacatctcca 45121 tccccaaaca aatttagttg ttcaataagc ctctcatatt ttacatatcc caaactgaac 45181 ttctgaattt ctcctccaat ctgtagggct cttcccacag cctttccatc tcagtggatt 45241 ataactccat ccttccagtt actcagacca aaacttttgg agttaactga gacacctctc 45301 ttttttttca caagtcatat ccaatgtgtc aacaaatttt ggtagtggaa atattgcggg 45361 attttttaag aaatcagaga gaccgatggg gttcaggagg atatttatta tttaggtgca 45421 ctggccaagt cagattaaca tccaaaggac tgagccctga acaaagagtt aagttacctt 45481 ttaagcattt tgtggggtgg gagagagggg tatctgtgca gggggaagca tactacagaa 45541 gtgagaaata aagacagtta ttcaattaat tgagacatgc attacatcat ttcttacttt 45601 tcaagaagaa acatgttttg cgacttgagt ttatctgtct agtgaccttg cagctgcaca 45661 gctagagaaa cagggtcttc acaatgcctg ggaaaggagg agaggtaagt ctcactagcc 45721 acagaaaaac aggcagttaa tttttaaagg gctccagctc tttctctttc tcagggggag 45781 ttgggttttg ttacatacaa ctgagtttcc gcttacacat tatttaattt cttttaattc 45841 ctgttccaaa agaagccaga tacaaaaggt tacatgttgt ctgattccat ttatatgaaa 45901 catatagaag aggtaaatcc atagagacag aaagtagatt agaggttccc aggggctgag 45961 gaagaaatgg ggactaactg cttatagggt acagagtttt cttctgataa aaatattttg 46021 gaactagata gacattttgt taggccattc ttgcattgtt ataaagaatt acctgagact 46081 tggtaattta taaagaaaag atgtttaatt ggcttacact tctgcaagct ttacaggaag 46141 catggtgccg atatctgctc agcttctggt aaggcctcag gaagcttaca atcatggcag 46201 aaggtgaaag gggagcaggc atatcacata gcaaaagcag gagcaagaga gggatgtggg 46261 gaggtgacag tcacttttaa acagccagat cttgtgagaa ctcattcact atcatgaaga 46321 cagtaccaag aggatggtac taaatcattc atgagaaacc ccaccctcat gatcaaatca 46381 cctcccacca ggccccacct ccaacactgg ggattacaat ttgacatgag atttgagtga 46441 gaacacggat ccaaaccata tcagagatgg tggttataca atgcgataaa cgtcactgga 46501 ttgtacactt taagatggtt gttttatgtt gtgtgaactt cacctcaata aaaaaaaata 46561 tttaatgtac attcagccaa aagaagattt ggaataggaa aggtcatgga gatatattaa 46621 cagccatttg atgggtggta aggaaaagag tggttattag actgttttgt ggccctcaaa 46681 aggtagaact agatcgagtt ggtgagcatt ataaaaccat cacaaaaccc tggagagagg 46741 acccagtgct gaagaaccgt ttgcctgcca tgagacatga gggaagtacc agtgaatgcc 46801 attgaaagca gcatccctgg gtccaaggga tggtcaaagg accactaccc aacccttccc 46861 tagcctacgc ctccattaca gatgaccgca agatttattt gctcattgct gccaaccaag 46921 gctgcactca ctgcagttgc tatcagttta tcatgggtaa aaggaatgtg cagtagagaa 46981 ctaactaact gcccacctac ctccacaatc ctatcaggac aaatcaccat ggctcacatt 47041 tccttacatt tggcatgtaa gcccctctta ctgtctgtca tctatctcct acacagttca 47101 cctaaactgt tctctcctga cccaaccttg attttcatcc caaatgcttc cttgccatct 47161 ctgggattcc tgtcttcacc atcaccaaac tcccctcaat cttccagttt cctgttcaaa 47221 cttttctcct acctccttgc tttgtcatta gcccgactgc ctccctagga catcacttcc 47281 cctgcagatc tctcaagatg acaatattta ttctccacac agcacatact tcagggttgg 47341 aaggcagggg caatcttctc ctttataatg agtgcctctt atatatgttt attcatctgc 47401 cctcttgtaa aacacacaca cacacacaca caaagaagaa ataaaataac tctgcttctt 47461 tgaagcttgt gacactgaga taaaccatct cactgtcctc attgtagtga cctctcaact 47521 cctcatgcaa gattggcttt ggcacctagt tcctgatctt cctttccctg taagcacttc 47581 tcatagtctt acgggacttc accatccatg gcacaaccaa taccacagcc cagatcctca 47641 gctctccaat gacattttcc tccactagac ttgagctacc tccttcccta ggcacagcct 47701 caacctcgac aacacctaag actgtaccgt ctctaaagtc acatgttcaa acacttcact 47761 ctttaaccac tgtctcctat tcttgcaagt gtattgctca agtatctcat tgcaatgctt 47821 tttacttcta cctcattgaa cctccaggcc attaaacatt tccttatttc taaccatcag 47881 gtttctcctt acttgtttgt ttgtttattt gtttcttttt tttttttttt tttgagacag 47941 ggtctcactc tgttgcccag gctggagtgc agtggtatga tctcggctca ctgcagcctc WO 00/09525 PCT/US99/17712 EPI-109 983 48001 catctccctg gttcaagtga ttctcatgtc tcagcctccc gagtagctgg gactacaggt 48061 gcatgccact acgcctggct aagattttgt atttttatta qagaaggggt tttgccatgt 48121 tggccaagct ggtctcgaac tcctaacctc aggtgatcca cctgcctcag cctcccaaag 48181 tgctgagatt ataggcatga gccactatgc cccacctggt ttctccttat ttatttcaag 48241 tctatgctgc actattaaaa ctgccttgac aaaaattata atagtgagaa aattatgaca 48301 gtgaaagaga tctgaaataa tcaaccccca tcttgccttt accttccaga ctgcccttaa 48361 taattcctga gcttgggcca agctatcttt ggcagaaatt tagtttatag tttaaatgat 48421 aatagccctt ctccaaaact aaactgcctt tgtaaaacta ataaaagacc accaatgaaa 48481 ggttaggagg atgagaggag cctgaattct gctaaggtgt agatgtaaac aattaccaac 48541 tgttattccg gaggtcacaa gatttgcaac atcgccaatt actcctgcag ataacagcac 48601 tatcatagaa tctgattggc cttttgagat gtcttttcag attcttacat ttcaactggt 48661 ggctctacct ggacccatca acaagtcctg tggctccacc cagaagcaga cttaacatgc 48721 acaaggacca ttttccacac cgctatgatt gcatcccaac caatcagcag caaccattcc 48781 tctgcctgcc aaattatcct tgaaaaatct tagccttaga attttggggg aggctgattt 48841 cagtaataac aaaaccccgg tctcccattt ggctggctct gcatgaatta aattctttct 48901 ctattgcagt tcccatcttg ataaatcacc tttatctggg cagcaaacaa aaggaaccca 48961 ttggacagtt acactgttgg cagatatatc ttgcttccaa aattggattt ttgtttaatg 49021 aatttattct gttttcttga tatttacaac tgtgaatgtt gtgtctgaat tctctttatt 49081 tcttgttgaa aagaactata ttgctacagc cagtacatac agatggatag ctaattactc 49141 aacacggggg gatgtgacca tcaccgcact gtgcaaatga atgttaccca ttgtccactt 49201 ttcccaaact acatagtgtt atatggtata tgacccaatc aacggtggca aagctccaga 49261 aataccacat agacatcagg gacactttaa actaatcagc ctatagtcct ttttcagtaa 49321 tttccaaacc tggttgtgca tccaaatcac ttggtaacat taaaaaaaca aaaaaatata 49381 cacgcaacat tcgctcccaa tcctactgaa tcagaatatt ttgggttggt tcaggaacat 49441 tcaggagttt ttcagggtcc aaggtttata taatttgagg tctctctttg agaaaaggaa 49501 cgtaaaagcg tcttgctttt atagatctta caaagatgta ttaccatgta aacacattcc 49561 taggacccag gcccttgtaa tttaaaggtt tatctaagta atgggccctg aagcttaatt 49621 ttcattatct tcagggcaaa ttacctgtgg gttagggttt aggaatatat ctctctgtgt 49681 atgtgtgtgc acattagcat gtacgcttgt gtggattttt tttttttttt tttttttttc 49741 tgagacagag tctcgctctg tcgcCaggct ggagtgcagt ggcgtgatct ctgctcactg 49801 caaactccgc ctcccaggct caagcgattc ttctgcctca gcctcttgag tagctgggac 49861 tataggcacg caccactatg cccagctaat ttttgtattt ttagtagagt tggggtttcg 49921 ccatgttggc caggatggtc ttgatctctt gacctcgtga tccacccgcc tccacctccc 49981 aaagtgctgg gattacaggo gtgagtcacc atgcccagca cttgtgtgga tgttttaagc 50041 tcccaggtga gtgaatacaa aactagatct ttcccttctg tagcatctgt actgtttact 50101 ctatgcatct caatattttt tcttttagta tctttccttt ttctctctta ttacttcctc 50161 ttgtgctatt tttacacctc cttttttaaa aaattttttc ccttttattt ctattgacct 50221 ttagccctca caatgattcc tacaagcccc atttctgtaa atggggattg aaataattgc 50281 tggacttttg agagatagat atattaaatt gcaaactggc agtagtgggg gcagttgata 50341 cataactagg ttttaaagtc tagccttctg agaccactca ttccatttgt gaaaagtgat 50401 tctacttctt attatgagcc aaaatatgca ttcattcacc catgcattga tttattcatt 50461 caataaatat ttgttggatg tccactctgt atcaggaatg tgctaggttc tgggaataca 50521 gcaatgaaca aggtaatttt tccctacccc taaggaactt agagtttagt ggggaagaca 50581 gacattaaac aaacaattgt gcaagtaata atctataatt atttattaca attaaaggaa 50641 ggaagagaca tatggattat gagggcatta aagaggagac ctagtgtaag tagccagttc 50701 tcgtgaaggg acatgtatta gttggagttc tccagagaaa cagaaccaat ggtgtgtgtg 50761 tgtgtgtgtg cgtgtgtgcg tgtgtgtgtt ggggtgtggg ggtgtggtat tttttataga 50821 aattgtctca cacaattatg gaagctgaga agtcccatgg cctgctgtct acgagctgag 50881 aaccaggaaa gccagtggaa tacttcaaag tccaaaggcc ctggaaccaa gagtgccagt 50941 gttggaaggc aggagaagat gggtgtccca gcttaaaaag acagtgaatt cactcttttt 51001 gctctacata gggcctcaat gggttggatc atggccaccc acattggtga aggcaatcct 51061 cttagtctac caattaaata ctaatctctt tggaaatact ctcacagaca cactgagaaa 51121 taatgtttta tcagggtgat agaaatcttc tggagttaaa caatggtgat agctgtacaa 51181 tcacatacat ttttaaaggg tgcgttttat ggaaagtgag ttttatctaa ataaaatttc 51241 taagaaagag acttaacaca gagataaaca taagcacatt tattgtcaac ctttatagtg 51301 ttatgtcaaa taggtctgac ataagcttaa ataaatatat actttaaaaa ttataaaata 51361 ttttaagtta taatttaaaa ttctcaataa aactcaaaca caaaccacac tggtatttca 51421 cacagctaat ttctaatqca gtttacataa atatttacaa cacttaaaca atttcaaaga 51481 aaataacact gtattccata catagcctga tcacagtagt tgttctctct tatttcccag 51541 agtttttctg cccctttaaa agaacctctg ctgttctgat ccttatcaca tctctgtttt 51601 gactgttggc tttgttgttg ccagtgttca gccagaactt ctctgaaact tttttttcaa 51661 cacatgctaa gttaatggaa gtgtaggaga gttttgattc tcacactcct caaggctaga 51721 gcagctttgg caattactga ctgagaattt ttcattgcca gtgatcaact gaaaactgga 51781 gattcctttg gaattgttaa atctgcttat aaataaacat aaatgcttgc tcacacaggc 51841 attcctctct tccagagcac cctaacatac agaagaaaac aaatagggaa taactattag 51901 acatcttcat tcgttaaaaa tctaccagat gactctttta catggtgagt ttctattgtg 51961 aatttaaaat cttccataat atacaagaat tatgtttaca tatcatatct gacaaacatc 52021 tttgtaggaa tgcaaagcac atccatcttt ctgtattctt ttccaacaaa gacattcata 52081 aaattatacc tttgtgtgtt tgcatttatg cttttattag ttcaaaacgt ttggcctcat 52141 ggaagttttt catcgtggaa accacatatt tctgaaaaaa tatctgacaa tatacaaacc 52201 ttccattcag tttttactct ccaattctac catgttttca aaaaacaact gtagtaaaaa 52261 cactcagaac tttattctgg ttaacatcat gccttgctag gggacaatag tttccctttt 52321 tgaaataaat ttaaaacaga tgtaacataa tttgttaata aacaatgagg gggtaatcta 52381 gaataagtaa cttttaccat atcatagttg acagcattta caagtttttt aagtccctac 52441 cacacttgta ttgaatgaag aagtatggaa gattataata tattcaatgc aagtaaaaat WO 00/09525 PCT/US99/17712 EPI-109 984 52501 atcacaatcc ttaagaactc tttaagaagc actgaatccc atagggatga aagtgattaa 52561 attgtgcata gtaaccctcg cacagagcat tcagtaggat ttgcaccatt aacaaccctc 52621 catgcatttg cctgtgggca ttcaacatct gtcatttttt taagttataa tatttttagt 52681 catttttttc ctctaaactc tggataatta ttattcattc ttatgacagc aactgtqtaa 52741 tcagctgtcg aaacactgtg aagggcaaaa gaaagaaagc cacaaaatat tgtgtttctg 52801 tgccaagatt ttacagcgag caagggagag ttagaaaagg aattctgaga tttcagagtc 52861 ttggtctctt cacctttgct tggaagaaaa tatcctttcc cttcattagc caacactttc 52921 ttgatcctga gagtaggaaa gggaacactg agtcttttca gttgaaggcc gtccttgcct 52981 gctggacttt gatctattga agtggtgatg ggtgttgcgg tttcagccat aaaggcatct 53041 ggcatagtag gcaagaaggg ccagagaccc gaggagagtt atctgtctct gttaacttca 53101 gtgtatccct ctagttcccc agatgcacct gtttctgtaa atataaacat gcatgtcatc 53161 agaacactta atattctgca tactgatcat gacaacaaaa tgtaccttct aacacagaca 53221 ctctcactag gatagaccat gtaggaacat cgaattctat tcagttagga cagtgatgat 53281 gtctacatat tatacctctg tcaaaaccta cagaatatac aacacagcac agagtgaatt 53341 ctaatgtagc ctgtggacat taatgaataa taatgtatca atattggccc atcagttgta 53401 acactaatat aagatgttaa taacaggggg aattgaaggg gtggtgggga gatatgttgg 53461 aactctttgt gctttctgct caatttttct gtaaacttaa aaccgcacac acaaaaaaag 53521 ttattttaat tttttaaaaa gtattcagag ggacttgacc tttccaaatt ctctcaaagc 53581 aggtcggagt agttaagaac acaaatttta gaaccagact gccagagttt gaatcctggc 53641 tacaccactt actagctttg agatttcaga caatttactt aacttctctg tctcattttc 53701 ttcatctgtg tgataagaaa taaagtaaca ggccaggccc agtggctcac gcctgtaatc 53761 ccagcacttt gagaggccaa ggcgggtgga tcaggagttc aagatcagcc tggccaacat 53821 gacgaaaaaa tacaaaatct ctactaaaaa tacaaaaatt agctgggtgt ggtggcaggc 53881 acctgtaatc ccagctactc aggaggctga ggcaggagaa ttgcttgaac gcaggaggtg 53941 gaggttgcag tgagccaaga tcatgccact gcactccagt ctaggcaaca gaatgagact 54001 ccatctcaaa attaaaaaaa aaaaaagtaa aaagaaaaga taagaaatat agtaccagcc 54061 cctatctcag agttcctagc ttagaaaaat tcccagaata taataagtgc aatgtaaggg 54121 tcagctatct tcattattat tatctatcat aaatgaaatt acacaataaa gctagatccg 54181 tttctttcct ctccttctac aaaaaataaa gcaactttcc agaacaatac ccaggtgatg 54241 atttctcccc tgctccctcc ctaagatatt ggcaagtttg gagggttcaa ggagaaacag 54301 agcatgtaga gaagatacct ctctcataac catttgtgat ttacaagtct tacctgattc 54361 ttttgaactt aaaggatgta agaaggcttt tggtagcttc catctgattc aaggctttgg 54421 cagctgctgt ggaatacatg agaacactag gtaaagcact gtcttccaac atgaagagag 54481 aaaaatatgt ggaatgttca atggcatgct ttgtataaga atgcaactta cctggcagga 54541 acaaatttct ttgctgcaaa agaaaagaca aacaaccatt aattcagact aaatgacttt 54601 taaggatata ttaaatccag atacaatatg acttaattca tcaagtgttg caaactcgat 54661 gcttcagggc ctctgtaata atcagagcac aagcatggct ctgtggcatc tagggtaaaa 54721 tgcaaagtgc acagccatcc aaagggcata gcagcttcct aatgccagca aatagctacg 54781 gggtcatctt gcccaattca gctcccaatt tttcatgaga agtccaaagt cttaatttaa 54841 atgtgagatt tcctattttg taaacgtcag aacttaactc aaaaatgttt taagtactct 54901 taaacatgta agccaaacaa accatgagtg tagtcagatg tgcttccata ttccttatga 54961 gagactctca aatttaagcc tgtactccaa ataaatctcc ttaggaagaa ttttatccat 55021 tttccttaga gtgctcatca tggcagttcc attgcacaat tccgggaggc atcatataat 55081 tcaacatgaa tagcaccccc tggagttgta caatattagg cacgactaac atttttattt 55141 cctgaaacac ttcccacact gagttgtact actaactctt ttcttaatac ttctgcttaa 55201 ttatactgca ttttatccag attctaatta ttgtttaaat cagtaagcaa gaccatgact 55261 tatcaatgag aaagaaatgt attttcaaaa acatttttga agtacattca taaacttcct 55321 cacctttccg taagcatttc cgaagccaga ggagaaatgg tgctaatgtc aggagggaga 55381 gtccagcagc agaaagtcca gctaccaagg gaatgttgga ctcagtggga gctaaggaag 55441 taagagacga agaaaggtca tgaggaagaa ttgatgttaa agtctctccg tcctgtccct 55501 ttggcctttt ttctgtacat tcattactag gagcagaaga gctatctagt ttaatacaag 55561 aagcagagat gtggcattac aggcctttga gatctgctcc aagccacctt tgaagctatt 55621 tccaccattg gcaggcagaa ctctaacttg ccaagctcgt tcacaatacc acaccacacc 55681 ttggttaata aacactgcac ttgcttgctc tcttgctctc actccctctt gttttccatt 55741 tcccctttct cctctcctct ctctgtctcc tttttccagt tgtcagaatt ctaccctttc 55801 catcaacatg caacttctgt tttttctcta tccccataca acttaatatt cacaacttgt 55861 caacctgggc gaactttctg gtttggatat aatgaatagt tgattactgt aacaagatag 55921 ctcccccttt ttctttttaa tcaccagaca accaccatca atcaatgcat caccttcaca 55981 ggtaggtagc aggccagacc agtgtcctgt ggctccacat gtccgagctg cagagccatt 56041 gagcgtccat ccttcaggac aggcgaactt gcacacagtg ccaaacacgg gctccccact 56101 gcagctcatg ttgatctttc ccggaactgc caggcttgaa cattttacca ctgcaaatgt 56161 taggtacaca ggcagagttt cagaaaaatc tactggaaaa cttccaaaac ttgcttaaaa 56221 gtcaacaatg aatgtaaagt gtaagcgcta cttagttttc agcatgtagg aaattaggac 56281 caaacccctt tggggcaatc taggttcaga aactttatga agtatttgac ctgtacccta 56341 aaaaagtctg cactcaattc taccttggca ggaaggaacc tcttctgtcc attgtccctg 56401 agatgtgcac tcaagttgag ttgatccatg taattcaaat ccctcctcac agctgaaggc 56461 acaagaggac ttgtaggtga attctccaat aggggaatga gcacacctca ccaaaccctt 56521 cgggggctgg tggacagcat cgcatctcac agctggaaca cacgagagag cactttagaa 56581 gtttgtttgc atctccagca atacgtttcc caaggtaacc aagttcccaa gctcttcaat 56641 agttcttttt atcttaaaat aaaataaaaa caaagactgt accttcacat gtgggcttct 56701 cgttgtccca ctcccctgtg gggccacatt ggagcctttt ggatcccttc aacacaaaac 56761 cctgctcaca ggagaactca cagctggacc cataacggaa actgccagaa gcactaggaa 56821 gacaattcat gtagcctcgc tcggggttgg acaaggctgt gcactggaaa gctgagacat 56881 caaaatgatg gtcagaaaat attgcagtgg aactagagag tacttggcgt ttgttgagtg 56941 aacccagttc attcaagcaa cacttggaga actgaagatt ctttataatt ccctggacaa WO 00/09525 PCT/US99/17712 EPI-109 985 57001 atgggaagat ggctgtgttt tctttgaatt tcagccccct cactgatcat ggcactaatt 57061 aaaagactaa ttaatcagaa cattagttcc tgagcactgt tcttctaaca cacaaaataa 57121 attatggtcc aaggaaagat ttcacgcagt ctgaggacaa catatgggtc atggatgttt 57181 atagatggtg ccaaaaagaa agaaaagaaa gcacccctat aaaatttgtc tgttttgcag 57241 tttggttttt gtgttatgtt ttgctactgg aaatcattct gtgctggctt tggctaggac 57301 aaggccagtg cctgatagta aaaactgctt gttttcaata tccttgctct cactttaaag 57361 tgaattaaaa tttactgctt atatatgcat caatactatc tctgtagctg acaccatgct 57421 tgaaacagtc tcatcactgc taattatgag ccatttcaga agacaggtgt gatgagagtt 57481 ttacattcaa atcatgttct cattattctg ctttccgaat tttctaatat gattccttta 57541 gattaagaat tctgtctatt ccatgctaat gtctacaaag ttttatcagc acatcacagt 57601 taaaaaaaaa cagcaaagaa ttcattctta acacatatga tcctttccct ggccaaacat 57661 tagttctttt aaatgaatct caaagatacg agggttgctc atcaaatctg atttctatag 57721 ttaaagtggg tattggtttt ttttttcact gtccaagttt gaagatggtt gttctttaag 57781 aaagtataaa tcgaaggatc tcaagcttac cttcacaaac tgggatttgc tgtgtccact 57841 gcccttgagt ggtgcattca acctgggctg gtccctgcaa catgaagcct tcctcacagg 57901 tgaagttgca ggatgatttg aaggtgaact ctccagcagg ggaatggctg cacctcacag 57961 agccattctg aggctggcgg acggccctgc atgtcacagc tgtaacaaat atacgcattg 58021 atattagcac ggcctagaat tagcttgccc atttccagta tgggttgaga gaaagaatgt 58081 tcacagtaag tctccatgtg gaacaactct acctttacac gttggcttct cgttgtccca 58141 attcccagat gaggtacact gaaggctctg ggctcccatt agttcaaatc cttcttcaca 58201 gtcaaatgta caggttgtgt tccatgggaa gcttccaggg ttttggaaac attccacgaa 58261 cccattggct ggatttgtca cagcatcaca ctcaaccact gaggatttta aagagcacca 58321 tgaattttac agaagaatga tcttttcact tcctattgag ctgggtgcct aacagagtga 58381 ggaagctgcc ttcaaagggt agatcccaaa gtcctatgtc aattcttagg gacatgcaca 58441 gccagaataa aagcttttat tctttttcat ggatattcta tcttttctga tttccacttt 58501 gcctatgctg agtggtctct aatctatgtt atcatttacg tgaggtaaaa atttaaaaaa 58561 aatagattcc agattaggag ttatgactag tactgacata cgtaggctat tcatttattt 58621 tagcccatca gagcctgaag aactgatttt tctttttttg gcctctggtt cagaaagata 58681 aaattaagag agaaaaagag atactaagac tgcttgacta tcatggtctt aagttagtcc 58741 catggcttgg aaaagttaaa cagggaaaca agatgagaaa tccattgaga tttctagagc 58801 tttattgttt tatggtctcc cttacaaatc accagagcct cagaaacacc catttcaagc 58861 atagaataaa aaaacctctc tcaacccaag caggtactgg gttggcaata tacattggct 58921 gagagaacaa attgtattaa aaacaaaaac aaaaaaaaaa ctttccctga agttttgaaa 58981 atgtaagttg aatcaaaaaa cagaagcaat gagggatgag ttacagaacg ttctgtgcat 59041 tctcagaggg atttaccatt gcaggctgga ataggagcac tccattctcc agaggacata 59101 cactgcatgg tctccatgct gcttggcagg taacccctat cacagctgat agagcaggaa 59161 gaattgtagc tgaagtttcc cagtgggtga ctgcaaacca ggcttccatg ctcaggggat 59221 tccagggctg tacagttcac aactgaaaaa gaaacccaaa tcagttctgc tcatctctca 59281 cctttaacag ataagaacac tggaaactag aactacagtt tggttttttt tttttttagt 59341 ttaaaaattt ataaaatttc taatggaatt tgtaaaattg actgtaattc tacccctttt 59401 cttttattca agaaaatgct gatccataac aacaacaaca aaaaagcagt gatgacaacc 59461 ataaaaaaga aatattgagt gatatgggga gagtagtgta attgtgttta cctcaaaact 59521 gttcaaatta tatgaacaaa cacagcaaac ttaggtacca caacaaattt cttgttactt 59581 ttctcacaac tgctaaaaat actacagtaa gcttccaacc aggatgagaa ccattcacaa 59641 agctatattt caaatttaag tactagaata cattacaaat tttaaaaccc taatgctgca 59701 ctgtctacta tagtagccac tatctgtgtg gctactcaaa tttaaacttg aattcgttga 59761 aatcaaataa catttaaaat tcagttcctc agtgtcacca gccacatttc aagtactcaa 59821 taaccacatg tggctcatag gtacacactg gaaaacacag ctatggaaca tttccattat 59881 cacaaaagct ctactgcaca acgctgtgct aaggaatctt ggagagaagc tcatctaact 59941 ctcttaatgt acaaatttag gaactgagac ctcatttcat tcaagtgact tgctccatgc 60001 tacacggcta gtcattacag agccagaggc cagagcatga accaagatac cctggactct 60061 gtaactcact catttctact gcaacgtctt gttaccacct agatgaggtg agtacatgtt 60121 cctcgcaggg acacagaatt acagtttatt gaatgtgtcc tgtgtgccag gcaccatgta 60181 accatgagcc tatgaagttc acactattat tatcctcatt ttacaatgag aaaactgaca 60241 tagagagtta aactatcttg tcaaggtgcc aaaataaata actggtgaat ctaggactca 60301 aacccagcag ggtctgactt catagtctca gctcacgatc accatatgac accatctgca 60361 ccagggaagg gaaggcatgc agacctgact ctaatgccag ctaggacgtg agatggtgct 60421 accatctcaa gtgaagaaag aggcaagaac cagacttact ttgctcacac ttgagtccac 60481 tgaagccagg gtcacacttg caagtgtaat tattgatggt ctctacacat tcaccgtggc 60541 cactgcagga tgtattggta caggcagcta cggaaaatac aaagcatgat gaggaggact 60601 attactgtgc ttatactgag tgcctttgat tttagaatca acagtgtgca acagagacat 60661 cagcagtcct acagagtgcc atagacttta actgaagtgt tttacaaagt tccaaatctg 60721 agtttcaggc ccacctatcc taaaccttga tgctaatgta tagctgtggc tggcacctac 60781 cgtagaaaat ttacttcttc acaaactctg aagacagttc ccctaccaca aataaacaag 60841 taattaaaat atgtattgtg tgtgtgcatt tttatatgta aagaactaca tatttgccta 60901 cagtatttat atatatttta tatatataca tacacacata tatgtgtgta tatgtgtgta 60961 tgtatatata taaaatgtat ataaatgctg taggctatat atatatacac acacacatat 61021 atgtgtgtgt gtatatatgt gtgtgtgtgt atatatatac atatccacat attcttgccc 61081 acattcacac aaaacagcaa aagagagaaa ctttagcagt taaacagaat cttttggaac 61141 ataaaatgac cacaatagag agcagttttt gcatgctgta aatttgccaa gatgcccaca 61201 cactgaaact acctcccact gctgccgcaa actccctacc tgtgtagcat agggcaagct 61261 tcttcttgct gcacctctca tcattccaca tgcccacatc tttttctctc ttgatgtaga 61321 tctccacgca gtcctcatct ttttgcctat tgttgggttc acctggagcc cagttcttgg 61381 cttcttctgt cagaggtttc tgggttccta cccagaccca cacattgttg acttttctga 61441 ttccaatcca gtaataactt ggtgaatagc tcaatatgga gtttaggtac tcaatctctt WO 00/09525 PCTIUS99/17712 EPI-109 986 61501 ctttgttttg aattgcaacc aggtgtgtgt acctttgctg acaataagca ctggcctcat 61561 cataagtcat agcttccgtg gaggtgttgt aagaccaggc tccactctct ttaatgagaa 61621 gcactagtgg gagaaaaaqa aaagaaatgg tagagtttgg tactgttgtg gtttaactct 61681 gacaactgtg ctttttattg tcttattttt ggcaatgttt gtgacatggc ccagactttt 61741 ctcatctttt caaaagtaag aagtacgtat gaagaaacag cgacttattg tttatctctt 61801 ttgtgactgc cacccactag gtaccttatc cacactcact cacaacatta tagtataccc 61861 attttgtagt agaataataa tcagaataac taagctttat tgagcactta gtatgcacca 61921 agaagcactg tatgaggtac tttccatgaa ccatgctatt gaatcctcac aatgcatctg 61981 ggaaataggt cattatgatc cacactttac acttaaggaa agggagacac caagaggtaa 62041 agtaaatgac cccaagccca gggaagaaca cattgcaggt agaggtcaag gatgctgcca 62101 gatatcctgt gcaggacagc cccagacaag caaggatatt tcagtctgaa atatctatag 62161 tgcgagaatg agaaatcttg gtctaatggc actgacttac ccaaagtgag agctgagaga 62221 aactgtgaag caatcatgac ttcaagagtt cttttcaccc aaaggtttag gcttgaaata 62281 ctttcctggg gagataaaac acaaaatgaa ttaaagaagg aaatcgtggg tagctagtta 62341 cattattcta ccatgatgtt taaggcagca tcctaagatt ttgggcaaag gacactagtg 62401 caataatctt tatttcagag tttaatcaaa taaataaaca aattttaaga ctttcattat 62461 ttaggtcaaa gagaaaagac aggttttagc tacaatacaa taagagcttg tacagatgtg 62521 gtttttatta gaaggccttt tgcatatctg tgtttcatgg cccgaggctg cccttataaa 62581 gcgttctgca cttaccgttt tgggaagcag ttgttcaaac acaggatctc tcaggtgggt 62641 atcactgctg cctctgtctc aggtcagtat aggagttttg atgtgaagtc agccaagaac 62701 agctgaacac tacttcggct gaggcccttt tataggaggg attgcttcct gtgaataata 62761 ggaggatatt qtccacatcc agtaaagagg aaatccccaa tggcatccaa aaactttccc 62821 ggqaatatcc acgatgctta aaattacaat gatgtcagaa actctgtctc ttgaagctac 62881 ttcacctttg tccatgcctt tatatcgtat atgcaatttt attaatatga caaaaatgca 62941 tgatttttaa ttataataac ataaagtcta tgtctttaaa aagttgtaaa actttgcttg 63001 ttagtagtgt ctctcatgta gttgtggtag taattagaat ttcagaaaca gaaggaaacc 63061 aagaataggt ttgtcatcca tagtctacta ccttcaattt ctcattcata gctgtggata 63121 accaatcact actcattttt tcttcctttt tcacctgcca attcaacata tttaacatgc 63181 actgtctcac agaggaatga ctcacaaggt agatattaat cttcagattt tgcacggcag 63241 ttatgcctaa attaaaatat tatctaaaaa taatatctaa cactcaaatg gttaaaataa 63301 tgccttattt taaaaaaaga aaaatgggaa atagatattt acatctggga aagtttcatg 63361 gtttgttcag tgaaaaaaat aaaaaggagg ccaggcacag tggctcacgc ctgtaatccc 63421 accactttgg gaggccgagg caggcggatc acctgaggcc gggagttcaa gaccagcctg 63481 accaacatgg agaaacgcca tctctactaa aaatacaaaa ttagctgggc atggtggcgc 63541 atgcctgtaa tcccagctac tcgggaggct gaggcaggag aatcgcttga acccgggaag 63601 tggaggttgc agtgagccaa gatcacgcca gtgcactcca gcctgggaaa cgagtgaaac 63661 tctgtcttaa aaaaaaaaaa aaaaaaagaa aagaaaagaa aaaaaataaa acggaaaact 63721 atatatatat atttaattgg tcaaaatttt gtttaaaatt tttgaaatgt taatgtgcaa 63781 agaataaaaa ttcttccaca atgttaacag tgactaactc tggatggcag gatttgggat 63841 aatttttata tccttcatta ttattttcag gattttaaag tttttttcaa tttccctttt 63901 tttcaccttt atagtaacaa gaatacagtt taaagaaact tgtctctagg ccaggcatga 63961 tggctcatgc ctgtaatccc agcactttgg gaggctgagg tgggtggatc acctgaggtc 64021 aggagttcca gaccagcgtg gccaatatgg tgaaaccctg tctctactaa aaatacaaaa 64081 attagccggg gtgtagtggc gcatgcctgt aatcccagct actggggagc ctgatgcaag 64141 agaatcgctt gaacccagga ggcagaggtt gcagtgagct gaaatcacac cattgcactc 64201 cagcctgggc gacagagcaa gactccatct caaaaaaaaa gaaaaaaaga aaaagaaaag 64261 aaaagaaatt tgtttccaaa tgcaacagaa ggagatgtat gtggtatcct atattcctgc 64321 tcttcatttt gacatttctt ctgggtgatt gtatacattc cccatctctg catcttaccc 64381 tatctaaatg atggtaacag taaatgggga tcattttaat ttccatattc tgtaggtttt 64441 cagagctcaa gtcaagctaa tattctatat ctacagcctt tcaaaatagg aggtctatct 64501 aaaaatgtac tgtcagcaga cctgaacgag tagtggtaaa agcctcgttt ttctctttac 64561 ttgttagcac tggtctttct gtgttcataa agatgtcaag acccaaaaaa aaaacaagaa 64621 aagagaagaa aaattccaaa aaagacaact gattagaaaa aaataactta attaacgaat 64681 ttaattcaac ccctatcaaa aagcatagaa tttattccct ccaccttacc actctcttac 64741 atgatccaga tactgacatt attccaattc tttatcccac tttacttagc tcaatgtggt 64801 tgttgcttca ataaattcag aagagtaatc actcatatag tgtttattta gattttaggg 64861 cagaatgtca agttgggtta atacattatc tgtatgtatt ttatttttaa taaagtatga 64921 atacataatc tgctattttt aaaaagcatg gtcaaatgta tagagtagcc aaatcttaaa 64981 aaacaattta tcttcgatat caataaagta cctaataatt atattgctaa tagaaattag 65041 tcgttaacat ccctagataa ctaactttat tattgcgaat ttttcataac taagtttata 65101 gtttatctct tccccttttt aaaattagtt caaagatatc taaaaatagc cccagtggtg 65161 atgaagtttc tattttactt acatatatat gtcctggacc cccaattata atctctaaca 65221 tttattgagt gcttactatg tgccaggcca tattctgagc attttgtatg ttcacctatt 65281 gattattcaa tccgtacaac agcctatgaa ataggtactc ctattatccc cattttacag 65341 atgaggaaat tgagaatctg gggattttat ctcattcaaa agcacagagc taagggttga 65401 aaccaggcag ttgatatcca gagcccactc ccttacctgc tactccaaac catgatttct 65461 tttgttgtta tgccccgaga ttccttgttc tacccaagtt tcctgtactc ttcttgccct 65521 cttcttcctg agacatcctt gaccatcaca gctctccact gagataactg tgtcctgggt 65581 tctgagacat gggggctgga agggacccca gggacagtga gcagtaggga gaggatgcag 65641 tgagaacaga ccctggatcc ccggtgcata ggcagggaga aagtggacaa aggaaaaaac 65701 aagcaaggca ggtggagcca tgcctaggta aagttgatcc ctaagccaca gttcccagaa 65761 gttcctgatt caaaagcaaa ttttctctaa ggtcaaaggq caaactgatt attctaaatt 65821 ctaaactgat tatttctaaa ttgaaaagc ttcagggaga gatcccaata ttcgaaggat 65881 aagagaaatg aggagtggaa gagataggtg agtaacagta acttaaatgt agactatata 65941 taatatataa tatatgtaga gtatatatat ataattacaa tatattatat atgtggaata WO 00/09525 PCT/US99/17712 EPI-109 987 66001 tatatattat ttatatatat ttatatattt tatatatata gatattttta tattttatat 66061 ataaatatag atatttttat attttatata taaatataga tatttttata tatattatat 66121 ataaatatat gtaaaatact gtgaaagaag aatagaatct tgagacctca aattcactat 66181 gccaaaggga aagttaagct tgggaaatga gtcatgcaaa aactgccttc cttttgttcc 66241 caaatacctg taatttcaca tgcttacttt atcttatata aaatgtagat gtactgagca 66301 tgagatccat gcataatttc cctctagtcc cttcttttta catgtaaagt gtagactcac 66361 tgagtgttac agagccttgc cacaatgtaa acacttgtct cattgccaac ccatctttcg 66421 tttattttct tcccctcctg cttgctcttt cccctctaaa gatggaagtt cccaaaactc 66481 tctttggaaa aagcgcaggt cacagatcct acagtgattt gtgtttcttt tacctgggac 66541 aaaataaacc tctaatctgt tgagatatgc ttcagttact ttttggttta caatatgtac 66601 atgtatgtat ataatttata tgtatataat atatgtactt gttttaacca gaggtatgtt 66661 attcaaaatc cattcatcct tacaattacc tgcattctcc cacagtattt tctgtgtccc 66721 tgcccccgag gttgtcactg caaatcaggt acatggatac tgggagctga tgggctcccc 66781 tctggctacc tgggctgctg aaggggccat agacagaccc agctttcctc tcgtggagag 66841 gccctgggcc agcgctgcgt gggagtggga ttacaaccag actatagctt cttcacctgc 66901 tttttcctat caggatttca taagaggcaa ttgcttgttt tttgagggtg ggggcaaatc 66961 agggggagtt gaagaggaaa ttgggtaaga tttgaatagt tgggcatgtt gaatattatg 67021 aatatcatct ccctcttcaa ataatccaaa atataccccc aagaaacagg ctgattagag 67081 gtgcttcaag gctccactga atctcccaag ctctgaagat gtagctagct gttaccggat 67141 tgccggtttt caagcctcgc ctcacatgga ccctcttggc agtttctcgc atgggggaag 67201 catccgctac atagatggga atgaaaagag gaaagaagac ggtgcaaact caggcacacc 67261 ccggtgtctg ccaccagtgc tatttaatct ctgaggtgtc acccttcctg gctttattgt 67321 ctcttcctgg aagtctcttg tcctctcctc cacacccttt aatcaggcat caaagacttt 67381 aaccagtttt gctgtgtgcc caggcccact cattctcact tttatggcaa agggagtggg 67441 agacagagag atagccagaa agaagagatt ggggacccca agacaaatgt tagaatttta 67501 accaaggcca ccctgtggac aggagattat tgggtttagt ggaaagcagc actggccaca 67561 accacacgtg gcaaaagcat ctatcgagga gtgaagttat atttggtgaa tgtgaccggg 67621 aagcaggggc agtggtgtcc tcctgccttc ctgaggcact ctgttccctt acctctgcga 67681 aggcttattt tacccctgag tgcttagttt tgaaagcctt agttccctct ctcccataaa 67741 aaagctctac tctgctaaca tctaagttac ctttgcagag tcttaggtag agggaggaaa 67801 tcccaataaa gattccaccc tatctgcaaa atacaaacat ggtatttctt gcattcccaa 67861 aattgtgaaa gaaaatgtgt atcaccacag tagagaatgg cattttttgt ttgatcaaaa 67921 cctaaatata tttgatgaaa atgtgtctgg ttctaagttt atttcccaga aagccatgtt 67981 tactcacttg gaatttatag acatcttata atatctgagt cgagtaggag ctccgggctc 68041 tacctcactc ttttctccca cacccagggg gaagtgtagg gttctcagac tttagaataa 68101 agaggaatca cctggacaac tcacctaaaa tgcacatctt caggtctcat actcagaggc 68161 tctgactcaa caggtctggg tggcgcccaa gaatttgggc tttaaatgag tatctcagat 68221 gattctaata cagaatgtgt aagatgacca gatcctatca cacttagatg tattggccta 68281 gggccaccta acttggagaa aatgttagta agaccccgtg gttggtgctc agctataggt 68341 accagaattt tgatcaaaat ttactatcat tgtgacactt ctcttcggaa ctggaaggcc 68401 agaaccccac ttgtaaagtg ctgggaaaat acaaggaaaa tttagggtga gtagcatttt 68461 gaattcttac acatggaaag taaatgtata agaattctta ccaataaaaa aaaagcaaga 68521 gagaatagct gctaaagaat taacacaaat atgtatatat tagttattct cttttctcct 68581 ctgattccag aggactttgt aattccacta attcttcttg agcttccagg atgatctgag 68641 acttgaattt ttcatgtgct ttttgcttcc tatttggcag catcttatct tgaagtttcc 68701 gctttctgct tggggaccta aaaactaact aatgggaatt tcttcaaaat gagcaaactc 68761 tggtgaattc ccaaagcgga agaaacaagt gaggatcggg ctggttaatt aagagaactt 68821 ttcctgaatg tagccagact gtttgccgac tgttgttaac atgagggaag aaatacccct 68881 ggattttaga agagcccctt gtttgttttc cttggccatt tgtgctgctt gttttgtaag 68941 tcagaaattt cctgaaggac tattattagc tttgttctca cgtcagaaaa cttctgctct 69001 ggccactttt aaacatataa cttggatttt actgtattag aaaatgtaac aattacagac 69061 agcactaaaa ggacaccaaa gggcaaagaa aatgggtaac ttttttttct tccccaaatc 69121 taaaataggt gattttggag aagtaggaga aaaacctgga ttttctagat ctctttagag 69181 ctcaacaact gatatagtta attatgtaag tctttgatat ttggaaatga ttggattaac 69241 cggataacaa tgaatattta aatacagtga tttggccagg agcagtggct catgcctgta 69301 atcccagcat ttggggaggc tgaggcgggt ggatcaccta aggccgggag ttccagacca 69361 gcctggccaa catggtgaaa ccccatctct actaaaaata caaaattagc caggcgtggt 69421 ggtgcaagac tgtaatccca gcaactcggg aggctgaggc aggagaattg cttgaacccg 69481 ggaggcagag gttgcagtga gccaagatca cgccattgca ctccagcctg ggcaacaaga 69541 gcgaaattcc atctcaataa ataaataaat aaatacagtg atttaacaca agagatttct 69601 atttcacact aatgagctct gtcactgggg caagcttctt tgcctcatta agtctcagat 69661 ttcccgagag cttatttatt tataccaaga gtgctttact accgtctctg ctagctgtga 69721 cataatatga caaaaggtat aaatatggga aaaggcacta atttatatca aagcgttctt 69781 cgtttttcct tgctgtgaag tttttagcta ataattcata agaatatacc atatttagag 69841 tgtttactat gcatgggcct ggcacttcac atacattgct tcttacaaat tttacaaagt 69901 gaaaggtaga tattaatctc attttatgga ggacaagata gagatctgga gaggttacat 69961 aacttgccag tgttttttca gttaataaat ggtagggtgg agattcaatc tgtgttactc 70021 taaagtccgt gtccttttta ttggctccat gcctactcag atttaaatct cagcagggaa 70081 gtaaacctta gtttttacat gagaaaatgt tacagcagcc ttctcggctt cctttacccc 70141 catcccagtt tcacgagctt agtgccttag atcgggttcc tttagaagca gacctcgaaa 70201 taaggatgtg ggtgccagtc atttattgaa aagatgatcc caagaaagcc tagtaggaga 70261 gtgaggaagt gagatgggga aaggaagaaa ctccacaaga agtgtgttaa taagcaggtt 70321 accgctgtgg gcagccatgg ggctcagctg cactaacaaa ctctgtctag tacagaaaac 70381 ctcagggtct ccccaaggag gggcaagaag tcgcctagg gtataatcc gccaactcag 70441 tcactggctg agagctgatc ctgggagggc atggttaatt cctctgcact ttcaagtgga WO 00/09525 PCT/US99/17712 EPI-109 988 70501 ttcctgtggt cagaaaaagc cctctacaat gaattccaga tgcttgtatt taaatctgac 70561 atgatctgaa tgctgtgttg ggacagggtg ggcgttatta gttttctgtc attactgtaa 70621 cagattacta caaacctgat ggctgcaaac aacacatatt tattatgtca tagtttgtgt 70681 gggtcagaag tacaggttag ctcaactagt ttctctgctc taggtttcac attgccaata 70741 tcaaggtgtc atccagttgg gctcttcttg ggaggcttgg ggatgaatcc actttcaagc 70801 tcattcagat tgttggcaga atccagttcc ttgtggttgc aggaccaagg tccctgttgc 70861 cttgctggct gttggccagg agtcattctt agcttctaga gactacctgt actctctgac 70921 tcgtgtctcc acttcacctt tcaaaccagc agcggctagt cgagtccctc tcttcaaatg 70981 tctccaactg tgccttcacc tcatttctcc tctgtgtacc atgtctgcct ctactgcttg 71041 taagggctca tgggattaca ttggatttat tcaatccagg ataatctcca tattttaagg 71101 ctagctgact agtgatctta attccatcta caaagtccct tccaatagta ctgtattagt 71161 ccattttcat gctactgata aagacatacc caagactggg caattcacaa aagaaagagg 71221 tttaattaga tttacagttc cacatggctg gggaagcctc acaatcatgg cagaagtcaa 71281 ggaagagcaa gtcatgtctt acatagatgg cagcaggcaa agagagagag cttgtgcagg 71341 gaactcctct ttttaaaacc atcagatctc ataatactta ttcactatca caagaacagc 71401 atgggaaagt cttgccccca tgattcaatt actcccacca ggtccctccc acaacatgca 71461 ggaattcaag atgagatttg tgtggggaca cagccaaacc atatcaagta cctagattca 71521 tgtttgatta aacaaccagg gagcagaaat cttcaggagt ggggggcatc tttagaattc 71581 tgcccaccaa ggctgggcgc ggtggctcac acctgtaatc ccagcacttt gggaggccaa 71641 ggtgggtgga tcatgaggtc aagagatcga gaccaccctg gccatggtga aaccccattt 71701 ctactaaaaa tacaaaaatt agccaggtat ggtggtgggc acctgtagtc ccagctactc 71761 aggaggctga ggtaggagaa tcacttgaac ccaggaagcg gaggttgcag tgagccaaga 71821 ttgcgccgct gcactccagc ctgggagaca gagcaagact gtctcaaaaa aaaagaattc 71881 tgcccatcat agtaggctgt cctacagaga cataacccag gaattaggtg aatggctaac 71941 ctaaattagc actgtgatgt gttttctgac ttggtcctta tagctcctct gcttagatgt 72001 ggaactaatc catgaatgca agggtttgtc tagagtttta agtgggagtt aaatatccaa 72061 agtacaggag atattatggg tgcctcatcc atgtcccctt ggcatttatc tttcttggat 72121 aacccaactc tattagtttt tatatctcac ttgttcctat actctgtgaa ctgatgtccc 72181 ataaatagac atttcatttt gccagtcttc ttgaacaata attacgatta ttaatctagc 72241 agttatcatt aattggccac ttcacattag acacagcact taggacttaa gaataccatg 72301 tcatttgatc atcataatat ggtcaggaat taagtattgc tatccaaatt ttacaaagaa 72361 ggcactgagg gttagagttt aaataacttg cttaagatgt catagcctgt aagtgacaaa 72421 actaggactc aaatacaggt ccatctgact ccaaagtcta tgttcttggc taccacactg 72481 cctctcctac aagtgacctg tggttttact actatattca cactctacta actttaccat 72541 ctcccatgag tctgtctaga ggagggcaca cacagcacag aaaacacatg aatgcaaaat 72601 aaggaagggc ctacttacta cacagagcca ttctaatacc tgatgtttgc tctaatccag 72661 ttttactatt aattagttgc tggtgcccaa gtttttactg agaaatgggg ataattttgg 72721 aagtcataat gatgccttct tctcataggg tattttattt gttgttgtat ctccaggccc 72781 caacacagcc tggcttttag taaatgatca aaaatacctg ttgaatgaat aaatggagtc 72841 acctgaaaca tgttaaacat ttgttcatgt gtcctaatcg tggatttcag gatagtaagc 72901 atcctaaaag gaaagcatgc acactgttct tgctacatta atttctcaca atataaaaaa 72961 agaaaagcat ctgaaaaaag ctgccagccg ctgtgtctcc taatatcaaa ctgagcacag 73021 atatggagaa gctaagggag agggatgatg ggccatgcct ctaacctcat catggcaaaa 73081 gtcctggggg tcagacccga ggagagcagg aagtgtcttt tgagggatac atttccacag 73141 tggaaataat gagacttaaa taaatattat atacacagtt caactgtttt tatgtgtaaa 73201 ggtagtaggt tttcacagta aggaagcact tctttttttt tttgtttgag acagagtctc 73261 gctctgtctc ccagcctgga gtacagtggt gctatctcgg ctcactgcaa tctctgcctc 73321 ctggattcaa gtgattctcc tgcctcagcc tcccgagtag ctgggacaac aggtgtgtgc 73381 cattacacct ggctaatttt tgtattttta gcagagatgc ggtttcacca tgttggccag 73441 gctgatctcg aactcctgac ctcaggtgtt ctgcccgcct ctgcctccca atgtgctggg 73501 attacaggca tgagccactg cactcaccaa gcacttctac tgatagcatt tacaaaccct 73561 tcttagaata tttaaaaatt ctaagagaag agtaaattga gccttcccaa ctaatactag 73621 gaggttataa ccttcatacc aaaactggac aatgcttgca caaaagaagg aagccaatga 73681 ggccacctag aaggaagact gggcattggg cccagtgagt cctggaaacc tcatctgtgc 73741 cagccacccc ggcatggcct gtatgagtgg atgagggtga cttgtccaca gacaatagcc 73801 atctagctgt gataaaggag tcaaggtagt cagctgcatc tctttcacct gtttgccaat 73861 gttacacagg ttgaaaagct aaggtttatg taaagcaagc atcaaagatg atgaaatgat 73921 caacctgaca atgagtacta tgctgcattg tccagaaagg aactgtggaa gattttgggc 73981 tgaatttcaa aacagaattt cctcactctc tggatgttgg cttacttggc ctttgatgtt 74041 cagaggtggt gcctttgtgt tgttgaacaa tgttgatttt ggagagaaaa cagagttgaa 74101 aaacccacaa gtcattccct ggggagtatt accggaatac agaggataat ttcagcaagc 74161 cagcaaggcc tcatctctgc ttctaataga taggaagaaa ggaagagagg aacaatactt 74221 ttttaagaag ctcagcttta tcgccttatc tcatagaaag atgcctccag tctgtctggc 74281 taaaggtaat tggcatggga aagtctttat ctgtgattct aacaagtgga atgtttccct 74341 tcattaagag agccttgtct ggcttgggga aatgaaacac tttctccgat atgagtgggc 74401 tgtaacccct gctactaaat actcagaaga aataaggcgg ttgtggagca gtcaggaatg 74461 agtcacttgc ctccctggaa tattcagaaa actgaatcaa aagtacattc ttctgggttt 74521 tcttagtcta atagactaag ggtctctact ttgttaaatt tctgggaaac agcatagaat 74581 gggagaaaaa actggtcact gtagtcatgc aaatctgcaa aacaaacaaa aaagtctggg 74641 tattgctgct aactagctat gtgaccttaa gcaaggtatt aactctctct gaatttcagg 74701 ttcttcatct gttaaatagc atatctgtaa aatgggaatt attttcatat cataatgctg 74761 tagctttaaa aaataaaata aaatggatga gataatcaga attaaagagc ctgggatata 74821 tagttaatat atagcagcat gtaaagatcc tgttagaaat gctaatttta cagttaacca 74881 tttggagatg atccgccaaa gctgctagtg tagaggcaac tgagaatttg cctgtccttc 74941 agaatatgaa taaataactg tcaatgatgt ctcaagccta gaaaaaccta tccatctgga WO 00/09525 PCT/US99/17712 EPI-109 989 75001 tgggtgggaa atttctaggc tagtattgag aagcccattt cttgggaaat aggtcctgga 75061 ctgagtgaag gaaaagaaac agtaaaaccc atggtaaagc agcaaggctc tctagaggct 75121 ctggagagga tgaattgaat tctagaagat gaagtaggga agacgcttta ccttcttgtg 75181 aaatggattc aaagattcaa agaccttcgg gaatctccaa ttgtataaat ggcaccatag 75241 ctgtatgttc catggaacac tacttcccag agatgcccag tgaaaaaaga atgccacagt 75301 caaataagtt tggaaacact ccattatgtg gccacctcct tgaagactct aatgcacatt 75361 agcatgttaa acagtcttga gaagtcctgc agagcagaaa ttgcttcaca tctgctaagc 75421 cggcagtttc ccaatatact tgattatgga tagttttttc cttacaacac cattctctga 75481 tatgcttcca atgacatgaa ataaatatat atgcatgagg ttcttcatta gggcatactt 75541 tttaatagaa aatattgaga ataatctaaa tataaatgca cagcatttac cttttctgca 75601 taaactatat acaggcatac cttggagata ctatgggttt ggttcccaca atatctccaa 75661 aaccacattc ggttttatga ccactgccat aaaaccagcc acatgaattt tttggtttcc 75721 caatgtatat caaagttaca tttttactat accatagtct attatatata caatagcatt 75781 atatctaaaa aacaacgtaa acaccttaat ttaaggctgt ggctggtttg attttctacc 75841 cagaccacta aaactttctt catatcagca ataaggctgt ttcactttct tactattttt 75901 tgtgatagca cttttccttt ccttcaagaa tttttccttt ctattcacaa tttgtttgat 75961 acaagaggac tagattttag cttatctcag tttaaggtgt ttacattgtt agctaaaaat 76021 gctaatgatc atctgagact tcagcaagtc ataatctttt gctggtggaa ggtcttgcct 76081 cagtgttgat gtctgctgac tgggtggctt tggcaatttc ttaaagtaag acaacaatca 76141 agtttgacat atcaattgac ccttcctgtc ataaatgatt ttttttttct ctgtagcctg 76201 caatgctctt tgatagcatt ttacccacag tagaattttc aaaattggag tcaatccttt 76261 caaactctgg tgctgtttta tcaactaagt ttatggagta ttagaaatcc cttgttgtca 76321 tttcaacaat gttcacacca tcttccccag gagtatattc tacctcaaga aaccactttc 76381 tttgctcatc tataagaagc agctcctcat ccactaaagt tttatcctga gattgcaaca 76441 attcagttac atcttcaggc tctacttcta attctagttc tcttgctgtt tctatctcat 76501 ttgtgcttac tttctccgct gaagtcttga accccttaaa gtcactcatg agggttggaa 76561 tcaacttctt acaaactcct gttgatgttg atattttgac ctgctcccat gattcatggg 76621 tattcttaat ggcatctaga atggtgaacg ttttcagaag gttttcagtt ggctttgccc 76681 ggatccatca gacgaatccc tatctatgga agctatagat ttataaaatg tatttctttt 76741 tttgtggggg catagcgtct caccctgtca cccaacctgg aatgcagtgg cacagtcata 76801 actcactgaa gactcaaact cctgggctca agtgattctt ccaccttggc ctcccaaaac 76861 actggattac aagcttgagc cactgtgtct agcccaaaat gtatatcata actaatgagg 76921 cttgaaagtc aaagtgactc cttgatccat gggctacaga atggacgctg ggttaccaga 76981 catgaaaaca atactcatct cctcatacat ctccttcaga gctcctgggt gagcaggccc 77041 attgtcaaat gagcagtagt atcttgaaag aaattttttt tctgagcagt agatctccac 77101 agtggactta aaatagtcag taaactatgc tgtaaacaga agtgctgtca tccaagctct 77161 gtttttccac tgatagggca aaagcagagt agatttggca taattctcta gggccttagg 77221 atttttggaa tggcaaattg agcattggct tcaacttttt tttttttttt tttttttgag 77281 acagagtctt ggtctgtcac ccaggctgga gtgcagtggt gcaatctcgg cccactgcaa 77341 gctctgcctc ctaggttcac accattctcc tgcctctgcc tcctgagtag ctgggactac 77401 aggcacccgc caccatgccc ggctaatttt ttgtatttta gtacagacgg ggtttcgcca 77461 tgttagccag gatggtctcg atctcctgac ctcgtgatcc acccgcctcg gcctcccaaa 77521 gtgctgggat tacaggcgtg agccacagcg cccagcctgt cttcaactta aagtcgccag 77581 ctgtgttagc ctctaataag agagtctgcc tgtcctttca agctttgaag ccaggcatca 77641 ttctcttctc tagctatgaa aatcttagat agcatcttct cccaatagga agccattttt 77701 tatgccctaa aaatctgtcg tttggtgtag ccaccttcat cattgatctt acctagatcc 77761 gctggataac ttaccacagt gtctacatca ttacttctgc ttcaccttgc acttttatgt 77821 tatggggatg gctcctttcc tctaacctca taaactaacc tccactagcc tcacattctt 77881 cttttacagc ttcctcgcct ctctcagagt tcacagaatt gaagaatgtt gggccttgga 77941 ttacactttg gtttaaggga atgctgtggc tggtttgatt ttctatccag aacactaaaa 78001 ctttcttcat atcagcaata agactgtttc actttcttac tattttttgt gatagcactt 78061 ttcctttcct tcaagaattt ttcctttcta ttcacaattt gaccgtttga tatgagaggc 78121 ctagatttta gccaatctca gtttacacca tgcctttttc actaagcttc atcattttag 78181 ctttttattt aaagtaagat gtgtgaccct tcctttcatt tgaacactta catgatgatg 78241 cctggcttca aagcttgaaa ggacaggcag actctcttat taggggctaa cacagctggc 78301 gacttttaag ttgaagccaa tgctcaattt gccattagaa gccattgtag ggttaattaa 78361 tttgcctaat tttaatatta tggtgtctca gggaataagg aggcctgagt agagggaggg 78421 agatggggaa acagccagtc atcagagcac acacaacatt tatcaattaa gtttatcacc 78481 ttgagggcac aggtcatgat acttcaaaac aattacaata ataaaataaa aaatcattga 78541 tcgcagatca ccataacaga tataatgata atgaaaaatt tgaagtattg tgagaattac 78601 caaaacgtga cacacagaca caaagtgagc acatgtcatt ggaaaagtgg tgctgataga 78661 cttacttcat gcagggttgc cacaaatact caatctgtaa aaaattcaat tatctacata 78721 gtaccataaa aacaaggtat acctgtttat ataatcaaga ccaacagaac cctagagaaa 78781 atagctcact ccctagctcg gagacattct aaccaacata cacttacctt tctttttgct 78841 gtgtacagaa ttcaaatccc tgtctcagca aaattgcaaa gtatcaaatg tcatgtccat 78901'ctaatactca aaactgcaaa tgttaagtct tgtaagccca gagaccactg tatatacaag 78961 tgttgctata agcattagtt cttctccaaa gaaaatagtc cacttggtag aaacaaacaa 79021 aaagaaaaaa aaagaaagaa aaaacatttt ttacaagaag attcagtctc ttacctacat 79081 aagcaaaaat atgagatgtt ctcttatcat ttttccatct atcttataat ctttggtgct 79141 gacttagaca ctcattttcc tttttgtacg tgaccatgta aaagttcaag tcaagaaaaa 79201 cttgttttga catttgtttt gctgagtgat gggtccctaa aagaaatttg gctttgcttt 79261 tgaaaagttc agcatgatat tgtgtgaatt tttcatggct aatgattttt agaacagttg 79321 tgatgtgttt aggtgtttta agaatatgaa gcattcagtg gtttaagttg gttgttataa 79381 aatgaaagaa tatgaaggaa agccttcttg tcttagaaca cactgattca caaataagca 79441 gcttctctca aaatgttgta attacaaaaa ttccaaggca aatataataa actccttgtc WO 00/09525 PCT/US99/17712 EPI-109 990 79501 ggtgctatgt ctagaaactt aacagcccca aagaaagtcc tgacaaggca aaaaatatat 79561 atatatatac aaattgtgga aqcagggtgt tgaaagaaga ataaagacta tataaggaca 79621 aactgtttaa aagggagggt atccttgaaa gcttgacact tgactctttt gacgaggctg 79681 agggaaaaca ctcagtttca cagattgctg gtacggatgt aaaatagtga catccctata 79741 gagaggaatt tggcaatatc tagcaaaagt gcttatgcat ttattctttg acctagtaat 79801 cccgcttcta ggattagtgg tgaagataca cctcaacaat aaaaatatat atacattagg 79861 ttattagtta tggtttaatt tttaatagca aaatatttaa aacaacctac atgaacaaat 79921 aggagactta ctgaataaac tatggtatat ctgtacaata aagtgcaatt cacttatgtt 79981 gttaatttgt tccaaaaatc cagagccaaa gagtatttgt tatgctctct ttagtataag 80041 aaaggggaaa taagatatgt gtgcatctgt ttatttttgt gaaaataagt acagaaagga 80101 taagtaagaa actagtaaaa ctagttatct cctagtgtta gtagaaatag aatgaaagtg 80161 aattaggctt ctttgagtat atgtttatat atagttttga cttttgaatt atgtttatgt 80221 ttacatagtc aaaaatataa attaatcaac agaaataaca aaaaaagaag aaatcacaag 80281 ctttaaaatt taatacaaac agaaataatt gaatctaaca gtatatcaaa gtgataacgt 80341 aaactcagaa gaaaaaaaca taatccaaca taccagtgga acacaatatt ctaactgtat 80401 acattcagtg gttatagtct aaggacaaga aaaattgcaa aaatatcttg aactttagct 80461 tgtaggattt ttattggtag caatactaat gtactaattc tgaaattaat gttcgtgtat 80521 tatagaattg agtaaatgaa taaatatgtt gatgttattg ggaactaaaa ttatcattct 80581 gggagtagag aaatataaat atggacttgg caaatgaaac aaagacctgc agagagataa 80641 ccatataaac tcattatttt aaaaattata agtgtcctag ctctgttact gaaaaggcct 80701 agattcaatc ttatcttgat agacaggagg gcaccccttt ctcagaacat ggtttccaaa 80761 tgccattctc cattaaaagg aacaaggtct tcttggagaa aagactgatt ctaggtctgg 80821 attaggtaaa gtacaacgtt agtctggaat ttcttgctga atcagaagta agaaagtgct 80881 caaaaacatg ggaacatgtc acaaacacac gtgaggcaac ttgaatcctc actggccata 80941 tttaggacaa tcgagcatca aaaaaaaaaa aaatgttgag aataatggat tctaacactt 81001 aaaacaaaaa ataatccata gcccacagaa ggggaagaga gggggagctc ttatttacag 81061 atgaatatca aatagcaaag acagaagaaa tgacagaatt agagaaacat cattttgcaa 81121 aacaccactg taataatcaa ttcaggcaag tattattaat ggatgtatta ctattgcgta 81181 aaaccagttg gggaacagga tattcataca gtctgaaggt gtcaccctaa acataactta 81241 ttacaagtgg aaaatggtgc ctttacaatg aagaaatcta gcagaaacca tcttaatcta 81301 gtgatcaaac ttagtatcac caataatgga tcatactgag tcatgtgtct cctaatatga 81361 tgcaccagga aggatgcaac gtcatgaacg ttgtattctt ttgtattcaa cagaccaccc 81421 agggtaaagg cagctttctc acttactaat cagaattgtt ggttttaatt cattttggat 81481 tttaagattt cttactttct tgtcagctca gaaatttatt taagatgatt tttatctttt 81541 attcaatact ttagcttgga gaaccattca gagtttctaa ctcattgtat tgccaaaaat 81601 agaaaacagc atggtttctt ttgaaaatgt ctaactttaa agttacttgt gtgtgtcact 81661 cagattcaca tagctttttt gcctagtaat gtagtatcat gtggcaaggc tataaaaatg 81721 tttacaatct tttatttaat atgactcttg agagtttatt ctaaggaaat aattgaataq 81781 taacaaaaca ctattaacac aaagcatagc aatttgattt gggcaaccaa acactggaaa 81841 caacctaaat gtccattaca ggaatcattt atgaagcaaa cactaaaata tttattgtga 81901 agattatgag aacatagaag acagttatga gagtaaattt gaaaacctga acacaaaact 81961 tacatatact ccaattgtaa cttataaaaa atacgtgcat ataaggataa aacagtacaa 82021 acaaaaaaat agttgcgtta gattggtaga attatggctc cttttgctgt cttaattttt 82081 tccttttaca ttttgataca ttattttaat tttaatttta aaattcaaaa gaatttgcca 82141 ctcatctttg ccacttcaag gaaaaaagaa atgtgttcga ttattctgtt cttagtatag 82201 ttttggcaat ttcctcacgt gtaaaaagag aatactatta ataatttcag tatctataag 82261 acaatataaa attaaagaat ctagcccagt aactggtaca tggaacgtaa ttaataaatc 82321 attatggact ttttttctca cacccaagta gggaggaatc agtggtcccc tagaggccca 82381 gtgtagaggt ggcagcacca atccctaggg gagaagatct tggtgatgat aattcctgag 82441 cagacagtta gctgagaatt caagagcaga aaagtaagaa agaaacaact tcttgctaac 82501 acctttccac ccacgtttcc ctgttctgtt gtactctgct taccctttca tggatggagg 82561 cagaggaaag agaaccaagt ttgctcttag tcattcacta tgttgtttaa tctgccttcc 82621 atctttctta tcagttcaaa ttagaatgta gacctgaatt taaatccccg ttctgtcagt 82681 tataatgtga ccctagacaa aacacattct ctgaacctca gagaacattc ttcatttgta 82741 gaatgggaag attaatctat attccacttg gatggcaagt cttttataaa ctttataacc 82801 taaacatgtg tgagttgcta gtatcattat gttggtaaag ttattctgag atatgataac 82861 agaactgttt tgtctaactc cactagcatg gttcaggttt agagagtgtg gaattaaaag 82921 gctttatcct caaatatgac ttaaatccga tttttctcat ccactttcct ccacaaacaa 82981 atcctcagga aatgacaaac tttacatggt taaacatcag ttttgtttag tctttgacat 83041 ccacatggtt aaatcataca tttgaaaact gcttatattt gtgttgtcta tgtctaaatt 83101 gaaaagactt attgaggaat agaagactac acatttttca gcaaacactg cacgttttgc 83161 agaatttccc caggcaccag tctccaggaa tttattggct actaacaata ctaagatatg 83221 gatgaatgag gaaatcaaaa tggagatctt gcaagttttg tgagaatggg tgaatggtcc 83281 aaatgaagag ataagttgtg aaatattagt acaagtaaaa attatttaca atgaaagaca 83341 ttttgtcaat agctatgaga attttaccat tgacccagaa attccatttc tttcttcaga 83401 aatacccacg taggtataca tataaaaagt tattcattac agtatcgttt ttcataggaa 83461 aaagttttaa aaatcagaag ctatctaaac tatggtatat ctaggtcata gaaatcaaat 83521 gactaaaaat gttaatataa gcatatgttt ttaaattaac ttggcttggg tcttcagcaa 83581 aattggcttc ttaacattgc actccagagt tagacttacc cactcagtca cttatcatgc 83641 aggagcagac tcctaatacc acatatcata gagcagagta ggacacaggt tctctgcagg 83701 caggcaaatc ccaaagagaa gggaggaaag ggctgagaca ctgcatggtc aatttcttct 83761 gaactctgca atgtacggag gtggacagtg tccacaaaga ttgctcccct ggacccacca 83821 tcataataac acaacggctt tgttttgttt ttgtttttgt tttttgacac ggagttttgc 83881 tcttgttgtc caggctggag tgcaatggtg tgatctcgac tcaccacaac ctccacttcc 83941 tgggttcaag tgattctcct gcctcagcct cctgagtgga tgggattaca ggcatgcacc WO 00/09525 PCTIUS99/17712 EPI-109 991 84001 accatgccca gctaatttzg tatttttagt agagacgagg tttctccacg ttggccaggc 84061 tggtctcaaa ctcttaacct caggtgatcc acccgtcttg gcctcccaaa gtgctgcgat 84121 tacaggtgtg agccaccacg cccagcccac aatggccttt tgtttacatc tctagtgcag 84181 cactcatttc atgttcttzc aagaagaata catatttcat ctttttattt tatacagcaa 84241 ttagcacagt gcctggcata aggaaaatga tcattaaaag ctgggtgaaa aacctaataa 84301 agctactgag gataggaact gcagaccagc atggaaagaa aactatgagc cagatattga 84361 catcatcctg aaaggcagaa gatttagtat aggcaagaag tatgcttttg gaatatagaa 84421 aatctggatt atgataaaa aagaatcata tttgtcttat cttacctact cacttctcag 84481 ttccacatgt ttctgaggct gtttgtcctt actttctttt ctgttttatc cactctttct 84541 gttctttaga ttggatcatt cctattgagc tgacatcaag ttaactgacc ttttattttg 84601 tccaaactgc tgttaaatgc atccagtgaa tttttaactt tatatagtat atcttttagt 84661 cctagaattt ccacatgaat tttttaagtt tccatttctc tgctgagatc tcctatttgt 84721 tcattcatta tgaccatatt tttctctaca ttattgagca taattataac agctcttcta 84781 aaattcttgt ctgcacaztc taacacctga attattctgg ggtcagtctc tgttacattg 84841 ccttattaca aaaacagtat aagtcacatt gccttgtttc ttaatatgca aaatgatttt 84901 tgattgcaga ctagacattt tgaattaaac attatagaga ttctggattc tcgagagagt 84961 attgacttgt tttttccatc aggcaggtaa cttgactgga ctcaaactcc aaactctagg 85021 tcctctgtaa tgggcaactg cagtaatctt tgtttagttc tttaagactt attggccagg 85081 cacgggggct catgcctgca atcccagcac tgtgggaggc caaggtggga ggatcacctg 85141 aggtcaggag ttcgagacca gcctggccca catggtgaaa ccctgcctct actaaaaata 85201 caaaaattag ccgggtgtgg tggtgggcgc ctgtagtccc agctactcag aaggctaagg 85261 cagaagaatc acttgaacct ggaaggcaga ggttgcagtg agccgagatt gtgccactat 85321 actccagcct gggtgacaaa agcgagactc cctctcaaaa aaaaatttat tggcactgct 85381 tggcatctgc tatgaataca tgaagttcat gggtcagcta tagatctggg cacgttatac 85441 acagaatttg ggtctccctt tctctggatt tctccttttc tggatttctt ttctcatttt 85501 ccagcagctg tggttgccct aaactcggtc ctctgtttct ttacggcagt aagatttggg 85561 aacttttagg ttttacctgc ctctcagaca aaataaaaaa taattttcat cttgatgcta 85621 ctcctttctt ccagatgtag acacctctct aatttccagt tgctttttat tgctctccag 85681 agtctaaaga ttatcattgt tttctgtggg agagttggtc tgataaaaac tactccccca 85741 aaactggaag ctggaagctt gtaattatga atagactttg agtagtattc ttctttggaa 85801 aaggatttta actactccct atgtacttct ttatttcctg tttttctcat ccgtaatctt 85861 tttattttca tacttcctaa gtcagacaat tttcctactt gaagattcag tgactgctat 85921 caaatgaccc ccatattact aaatacaata tccccaactg catttataaa aagaaaattt 85981 actgtttatt agtaaacaat gttgtagaat agtaaaatat tgctgggctt tggagccaga 86041 taatcaaggt tagaatccca gattctaact tactagctgg tgtattagtc ctttctcatg 86101 ctgctaataa agacataccc cagactggga gactgggtaa tttatgaaga aaagaggttt 86161 aattgactca cagttcagca tggctgggga ggccttagga aacttacagt catggtggca 86221 gcaaggagaa gttccaagca aagagggaaa agccccttat aaaaccatct gatcttatga 86281 gaactcactc actatcacga gaacagcatg agggtaactg ccctcacgtt taattacctt 86341 ccaccagttc ccccccatga cacatgggga ttatgaaagc tataattcaa gatgagattt 86401 gggtggagaa atagccaaac catataattc cacccctggc ccctctcaaa tctcatgtcc 86461 tcacatttca aaactcaatc atgccctccc aactgtcccc caaggtctta actcattcca 86521 gcattaagtc aaaaatccaa gttcaaagtc tcatctgaga caaggcaagt cccttctgcc 86581 tatgagccta taaaatcaaa agcatgttag ttacttccta gatacagtgg gggtacaggc 86641 gttgggtaaa tacactgatt ccaaatggga gaaattgcca aaacaaaaga gttacagacc 86701 ccatgcaagt ccaaaaccca atagggcagt cattaacatt aaagttccaa aatgatctcc 86761 tttgacttca tgtctcacat ccaggtcaca ctgatgcaag aggtgggctt ccaatggcct 86821 tgggcagctc tgcccctgtg gctttgcagg gtatagcctg cttcctgttt gctttttcac 86881 aggctgacat tgagtgtctg tggcttttcc atgagtatgg tgcaagctgt tggtggattt 86941 accattctgg ggtctgggcc aggtgcagtg gctcatgcct gtaatcccag cactttggga 87001 ggctgaggtg ggggatcaca aggtcaggag atcgagacca tcctggctaa cacggtaaaa 87061 cccagtctct gcttaaaaaa tacaaaaaat tagccaggcg tggtggtggg tgcctgtagt 87121 cccagatact tgggaggctg aggcaggaga atggcgtgaa cccaggaggt ggagcttgca 87181 gcgagctgag attgtgccac tgcactccag cctgggcgac agagcaagac tccatcaaaa 87241 aaaaaaacaa aaaaaccatt ctggggtctg gagaatggta gcccttacag caccaccagg 87301 cagtgcccca gtggggactc tgtgtggggg ctctgacccc acatttccct tctgcacggc 87361 cctagtagag gttctccatg agggttctac ccctgcagca aacttctgcc tggacatcca 87421 ggcatttcca tacatcctcg gaaatctaag ccgcggaggt tcccaaactt caattcttga 87481 ctcctgtgca cccacaggct caataccaca tgtaagccac caatgcttgg tcagggcttg 87541 aaccctctga agcaatggcc tgagctgtac gttgacacct tttagcctag acatctagga 87601 cacagggcac catgacccga agcttcataa agtgggaggg ccttgggact agctgaggaa 87661 accatttttc catcctaggc ctccaggcct gtgatgggaa gggcagccat gaaggtgcct 87721 gacatgccct ggagacgttt tccccattgt cttggtaact aacattcagc tccgtgtgca 87781 gcaccaactt acttatgcaa atttctgtca ctggtttgaa tttctcccca gaaaacagga 87841 tttttctttt ctattgcatc atcatgctgc aaattttcaa acttttatgc tatgcttcct 87901' gttgaagact ttgcggctta gaaatttctt cccccagata cccaaaatta tctctctcaa 87961 gttcaaagtt ccacagatat ctaggggaca aaatgttgcc agtctctttg catagcaaga 88021 gtgaccttta ctccagttcc caacaagttt ctcatctcca tatgagacca tctcagcttg 88081 gacttagttg tccatgttac tatcaacatt ttggtcaaag ccattcaaca agtctctatg 88141 aagtttcaaa cttccccatg ttttcctgtc ttctaatagc cctccaaatt tttccaacct 88201 ctgtctgtta cccagttcta aagtcacttc tacatttttg ggtatcttta cagcagtggc 88261 actccccatg gtactaattt actgtattag tctgttctca tgctgctaat aaagacttac 88321 tcgagactgg gtaatttata aagaacagag gttcaactgg ctcacagttc agcatggctg 88381 ggaggcctca ggaaacttac aaacatggtg gcagcaaaga gaagttccaa gcaaagaggg 88441 aaaagcccct tataaaacca tcagatcttg tgagaattca ctatcatgaa aatagcatga WO 00/09525 PCT/US99/17712 EPI-109 992 88501 gggtaactgc ccccatgatt aatttacctc ccacagggtc cctcccatga caggtgggga 88561 ttatgggaac tacaattoaa gatgagattt gggtggggac acagccatac catgccagct 88621 agagagcctt aagaaagtca cctaatctcc acaaataaaa ggtttcctat ttgttcaaca 88681 aaaataatga cacccctttt atgggatttc tgtgaggaca aatgataact aacatagcct 88741 tgcatagtgt ctggcacaaa atagctactc aaaaaataat agaaacaaca tttaaaaaat 88801 gtagacttta ttttttagag ttttatgtac aaagcaaaat tgagcagaat gtacagagag 88861 tttccgtata gcactcczta cccccaagca cagatagcct cccccagtat cagcatcccg 88921 caccagagtg gtacatttat tataactgat gaatctatat tgacgtgtca ttttcatcca 88981 aaatccatag tttatattag ggatgcctct tggtgttgta ccttctatgg gttttgacaa 89041 atgtataatg acatgtattc accattacag tatcataaag aatagtttca ctgtcctaaa 89101 aatctttgat cttcttccta ttcatcactc cctccccatt aatccctgac aactactgct 89161 aattttcctg tctccattgt tttgtctttt cctgaatgtc atatagttta aatatacagt 89221 atgtaggatt ttcaaactgg tttatttcac ttagtaatat gcatttgatg ttcttccata 89281 tcttttcaaa gcttcatagt tcaatattta tagaattgaa taatattcca ttgtctggat 89341 gtactacagt ttatgtattc attcacctat caaagaacac cttggttgct tccaagtttc 89401 aacaatcatg agtaaagctg ctataaacat ctatgtacat gtttttttgt gaattgaaca 89461 ttttcagctt ttttagctcc attcctagga gtgcaattgc tggattqtat gataagggta 89521 tgtttagtgt tgtaagaaac tgccacgctc ttcctaactg gatgtactgt tttgcattct 89581 caccagcaat gaaagagttc ctgttgctcc acatactcac cagcatttgg tgtcgtcaat 89641 gttttgagca atagcatttt gatctaactt ttcctaggta ttctttttga aggaaataat 89701 atgacagata atagagaaag gatatacqag gacagttctg tcctttattt atagtccatc 89761 atttaatgaa ggactctgtc cacacttggt atttttaact ctgatcctcc tctcccatga 89821 actctgacaa tctcctaaat ccctgttgct ggcacacatg gttgtgtatc aggccccctg 89881 tggtctgtct gaagcatggc tttttttttt tttttttttt tttttttgag acggagtctc 89941 gctctgtcgc ccaggctgga gtgcagtggc gcgatctcgg ctcactgcaa gctccgcctc 90001 ccgggttcac gccattctcc tgcctcagcc tcccgagtag ctgggactac aggcgcccgc 90061 caccacgcct ggctaatttt ttgtattttt agtagaggcg gggtttcact gtgttagcca 90121 ggatggtctc gatctcctga ccttgtgatc cgcccgcctc tgcctcccaa agtgctggga 90181 ttacaggcgt gagccaccgc gcccggcctt tttttttttt tttttttttt tttgagatgg 90241 agtctgtcac tctgtcaccc aggctggtgc agtgatgcaa tcttggctca ctacaacctc 90301 catctttcag gttcaagtga ttctgccacc tcagcctccc aagtacctgg gattacaggt 90361 gcccgccacc acacccagct atttttttgt atttttagta gagacgtagt ttcaccatgt 90421 tggccaggct ggtctcattc ctgaccttga gtgatccacc tgccttggcc tcccaaaqtg 90481 ctgggattac aggcatgggt catcacatgt ggcctgaagc atgactgttg ctttaatcat 90541 atgaaatact gctctgtatt gttatctatt tgaaatgcca cacctcctga gctaaattgc 90601 aagcttttat ggagcacaaa ccatatttat atatattagc atgataccat gacacatatc 90661 aaaagctgtt atatattgtt acgtgaattg attctttctc agttaagagg acctctgtag 90721 tagcactttc ataccgttaa tttttcattt tgtgcccagc ccctactctg tgaaaaatga 90781 aatgaatcct gttatcattt ccctcccagg ccttttctcc ttgtggacaa tgtgtggctc 90841 aagagaaaat tcagtcagta aatttgttca gtgcacaaac tctttatcac ctctcactgt 90901 tctcaagtga gatagaacag aacatccatc cagtgtctta caaattgtct ggtatatagt 90961 aggcactcaa taaatgtttt ttgaataaat gcatacatga atcctattcc tatatatagt 91021 atggtagaca gatcattgat acccaaagat gcccaaatgc tgatccccag aacttgtgaa 91081 tatgttacat ttcatgtcaa aagggacttt gctaatgtga ttaaggattc agacccttgg 91141 attgtaagat tatcccggat taaccagggc caatctaatc acatgagacc ttaaaaaagc 91201 agaaaacatt tcccagctgg gttagagaga gatgagacag agtaaaaagg aaagagattc 91261 agggcatgaa aatgactcta cccactgttg ctggctttga agatagagga actaggccac 91321 aaaacaagga gtatgagtgg ccttaagaaa taggaaaaag ccctcatctg acagccagct 91381 agaaagcagt cctctgacca caagaaattg gattctgcca accactcaaa tgagcaagga 91441 aatggattct cccctagaac ctccagaaag gaacacagct ctgtaatgcc ttgattttag 91501 ccaggtgaga cctgtttcag acttttgacc tatggaaata taagataata aagttttatt 91561 gtatgctgct aaatttgcgg tagtttatta ctgaagcaat ggaaagccaa tacagacaga 91621 atatacagag agaaagagaa tgagttcttt cctgataatt tgtaaatatt tgggtcttca 91681 ctggacaagc ttcacagagg attcactggt tccctagcaa accagcatgt ccagtcctgc 91741 agcctccctt tcttaggccc agcatatgtc agctgtgtgc atagaaaaat caaagcagga 91801 ccctgagtag ttggaaagaa aagatggttg gaaatgggtt gcacttcaag tgaggaaaca 91861 agaggtagga gaccggcatc tctttctcat atgtcccagg ctgactcttg tgagttgttt 91921 tcccttggag gctatcgatg acagtcacag taacctgatg gaacctggat catgatgaaa 91981 gaagtaagtg tcaatggctc cgacttccaa ggactctgat gtcccacagc actagctaaa 92041 caaagccagt tggaaatgag cttaaatggg gaatttcctg aatatattcc ctattgttag 92101 gaagccaggt tggcttcctt gcctacaatt atgccaagca gtcacactat agagtcccta 92161 gggacatgat attaagtgat tcttttaaca caaacaactt aataatcatt tatactaata 92221 gcaaaacggc caacggctga tattccactt gaagtagaat tggctatcca actggaagag 92281 aagacaggaa gacgtgatct ccagggagcc actaaaagga ttggcacctg cctctggatt 92341 ccccttttcc ttatattacc tctcagcact ggcaggcctt tatttcagga tacagtttca 92401'caagtattar gtcacgtctc tgagaattat gttggtagat atttgctcct ctggccagaa 92461 agacctagtt tggagtctgg agtcatgaag gtgacataca tgtagctagt gacataagtg 92521 tagctagtaa aaatagtgag taatggccct gaaattctat tgaatgccca aagtgctgac 92581 caggaacaag catgctctag cttatctcac aaggaacttg acaattttct tcaaaaatcc 92641 tagtagctaa gatttcttag taacaaagcc actaaggcac aattatgatt aacttgaccc 92701 ttaggtgact tttaaggact attctataaa atattacaac taatagtgga tccaagccag 92761 cacactctgc tatataagat taattgacag tgtccacact ggtaaaataa gttgtttcat 92821 aaatacatta gaattcattt gcactttcta cacagcccca agtccagaac tttccccaga 92881 ataggtctat gttttgcaat ctgctactcc atacagagat ttgagttcac ttggcaattt 92941 agtgctgctt atatgtgacc agttagtctg ttttacttat ctatgccita aacattacta WO 00/09525 PCT/US99/17712 EPI-109 993 93001 tacttactaa ctccaagatg cctggtctca acttgacaaa aataccccaa gttgggaaat 93061 ccttatgtga atatgtagat agtcacaatt gctggttgat gatgatctgt cttttcctgt 93121 atttgagaaa atggagataa aatggaccaa tccaaataat ggattaaaca tgggaatagg 93181 tgagagagag agaggaatac atggtggctc tcagtgtctg gcttaggcag taaacacttt 93241 cgttaataaa gacggaaaat aaaaaaggaa taattggtgt ctaggggaaa ataatgagct 93301 caagttttaa cactctgagt tcccggatgt gagacatcca ggcgcattta tccaagaggc 93361 agttggaagc aacgttccgg agcttaggag agaggcatga ccaaaagctg gtgggactgt 93421 gaaaaggtat ggccattctg gaaaactgtt tggcagtttc ttagaaaatt aaacatgtac 93481 taacaaccca gcaattgtac tcttgagcat ttgtcccaga taaatgaaaa aaaaaaaaag 93541 catttttttt acacaaaaac atatacatga aagttcatag aagtgttatt cataaaaaac 93601 tggaaaaaac tgagatgtct ttattgagtg aatgcttagg caaacggtgg tctatccata 93661 caatggaatt atgcttagca ataaagagaa aagaactatt gatacatgca ataacacaga 93721 tgaatctcaa aggaattaat gctgagtggg aaaaaaagca catctcaaaa tggtatatac 93781 tgtactattt tatttactta acattttaaa aatagcaaaa tcataqagat ggagaacaga 93841 ttaatgggta ctgtgttttg ggatggggag tgagaaaagg gtaaggtgta aatataaagg 93901 ggtagcacaa aagagccttg tggttgaagg attctatgtc ttggttgtag tcgtgattgc 93961 aggaatctac atgtgataaa attgtatggg tctacatacg catacacaca agagcatata 94021 aaactggtga catgtgaaga agctccgcac attgtgccaa catcagtatc ctagtttcaa 94081 tatcagacta cagttataca aaacattgtc attgagggaa actgggtaaa gggaacacag 94141 gacatttggc atatattttt gcaatttcct gtgaatccgt aattatttaa aaataacaga 94201 tatactacat atcaaaaatt taatgtcata aagttgatga gtttacctag tggatagctt 94261 tgttaatatc tgctataaga ctactgaaaa tgacagttat gcaagtataa gctcagagaa 94321 ctttcctccc ccttcgtaaa tgaaatgagc aaaagaaatg aaacaggaaa ggcaagcagt 94381 actgaaaaca gggaagggct cttccccata taactatatc tgcgacttca acagctattc 94441 atccagaaac acagcctctt gcgctaagag gaaactttgg ataacaatat gttttcactc 94501 tccaagagag aaaatggata gattaatttt taagaaaaaa aaaaaaacct caccaatttc 94561 atgctgtggc ttgcaccttt aatcccagct acctacaagg ctgaggtgag aggcttactt 94621 gagcccagga gttcaaggct gcaatgagct atgattgatt gtgctatcgc actccaacct 94681 ggagtactaa gctaagagct aagaacacag ctgagagcgg agaagaaaca aacaaatctg 94741 accaataacc cccactcccc tcattttact ggagtgagct gagactgctg gcaaacatgg 94801 cctttgacct agcctgaact gtagcaaaag tcatcagata tttttccacc aatcaacaga 94861 cagaagtggg gagaaaacaa tcgtagttca taactacaac aagcagataa acgaaggcca 94921 tggtgaggga tggaagacat tgtgatatat caaaggcagg ctcatttaaa actcaaccca 94981 aattccaaac aaaatatata attgaatatg tattaatgcc aaaggagctt gagtgagctt 95041 tagcacaaac cccgccctcc agcccccacc caaaaaaatc actctgttct ctccccattc 95101 tttgataggc atacttgctg ttttctcaca gccaaggtac agaggggact tagaggaact 95161 agaactctaa tacactgcta gcaggaatgt aaaatgaagc atctacttca gaaaaccatt 95221 ttatcagttt ctagaaagtt aaacatagac ccaccatgca gcccagccac tctactccta 95281 agtatttaca caagagaaat gaaaacgtgt ccccacacag ttgtatttaa aggtgatggt 95341 tagccttgtg tgtcaacttg gctaggctat aatacccagt tactgaatca aatagtaatc 95401 taggtgcatc tgtgaaggta ttttgtagat gtggttaaca gctacaatct gttgacttca 95461 agtaaaggag attgctcttg atagtatggg tgggcttcat ccaatcaatt gaaggcctta 95521 agagcaaaaa gtaaggtttc ccggagagaa agaaattctg cctcaagact gcagcctcaa 95581 ctcctgcctg agtttccagt cagccagcca gcctaaagat ttgctaggca ttataatcac 95641 atcagctaat ttcttaaaat aaacctcttt atatatattg atacaatgaa tggttatagc 95701 agccttattt gtaatagcca caaactggaa acaacctaaa tgtccttcaa taagtgaata 95761 cataaacaaa ttgtggtata tccacaattt ttacgcagca gtaaaaagga ataaatggtt 95821 gaataaggaa taaacacata acaaggatga accttaaaac cgtaaggctg aatggaaaaa 95881 gtcagacaaa actaatacat actgaataat tccatttata ttgaagttct agaaaatgag 95941 gactaaccta tagtaacaaa aagcagaaaa attttgccca ctggtgatgg agggggcgca 96001 ggtattgtag agtatctgag aaaggacaac tggataaaag ggggcacaag aaaacttttg 96061 agggtgattg atatgttcat tatcttgtgg catggtttca taggtgcata catatgtcaa 96121 aacatcaagt tatacacttt taaaatgttc agtttactgt atatctatta tacttcagta 96181 gagaggaagg aagaaagtgg gcagggtqgg ggagaggaaa ggaaacgagg gaggaaaggc 96241 cctaatagga aggattttgg agtttagatt ttaaaatgat aaaggatgtt tgacactcta 96301 ggcatatgac gaatatagga ttatgagtcc acaaaaacca ccaggaagtc atgtatgttt 96361 atacttttaa gtgaaggatc agtggattat caactcccta atgctttgcc tctctatgac 96421 tggctgctgt ccttctcatc ccaatactcc ttccaaagcc ccttgcttaa atgtaagcct 96481 tctttcctcc tttcaacaca tcctgcattc cgtgacaaaa taagttttcc ttaaacagaa 96541 tqtacagcat attatttgta caattaaaaa tttttggcca ggtgtgatga ctcatgcctg 96601 taatcccagc aatttgggag gccgagatgt gtggattacc tgaggtcagg agttcgagac 96661 cagcctggcc aacatggtga aaccctgtct ctactaaaaa tacaaaaatt agctgagtgt 96721 agtgtggcag gtacctgtaa tcccagctac tcaggaagct gaggcaggag aatcgcttga 96781 acctgggagg tggaggttgc tgtgagcaga gatcagacta ttgcattcta ggctaggaga 96841 cagagtgaga ctcggtcccc aaaaaaaaac acattttttt ttaatgtttc ctccttgcct 96901 gtaggaaaaa ggctctgact ccttagcctg ggcatcagag ctctatctaa atggacttta 96961 acctgatttt gtggcactaa ttccattgca gtacttgtcc gctcactggc ctgtgcctct 97021 ctgccactat ttttggaata atgtcctctc tccatcttgt ttactcaact atatccaacc 97081 tctaaggctg tgctcctaca aagcctcccc tggctacttc agcccacaga gatatttaac 97141 tgctctgcag ttcaggacat tcttctgact ctttaaatca catttactta tatatgatct 97201 tgtgatattt tttgttgacg tgtttacttt aattttcttc cataacctat tcattcaaca 97261 aactcaacaa ttatttatta aatgccaagt tagaaaaata ttattgattt tatatagatt 97321 atagatatgt ttgaaatttt atttggcaat ctgcaagtag aaaaataatt ataatgtggt 97381 atatctgtga tagaagtatt agtgcagaga ccatggggaa cataatccag cctggaagtt 97441 caggagagat acgtggaaga aaggacgcca gagccttttt cctacaggca tggaagaaac WO 00/09525 PCT/US99/17712 EPI-109 994 97501 attaaaaaaa attttttttt ttgagatgga gtctcactct gtctcccagc ctagactgtg 97561 gtggtgcgat ctctgctcac tgcaacctct gtctcccggg ttcaagtgat tctcctgcct 97621 cagcttccca agtagctggg attacaggta cctgccacac atggatgata aatatgatca 97681 tattttcttg ttcttttcct cctcagttgt cttccctgaa gaaaggaatg ccttttatag 97741 atgacaaact cccattctca agaacaagga tttttgacca atttaattta atcagatgtc 97801 tggctttgac ctagaaacac agtcacgaaa cttggtgatt agagaccaat tcccaaacat 97861 gagcatttct taggaaacac agtaaagatc tgagagaccc aagagcagaa gggcgagaaa 97921 ccaaaagcca tcagtttgca taggaaacac cttgtttagc ctaatctttt tatttttatt 97981 actctattag tcactacaac tattttctga ttgctatggt gatagatggt ttaaaacaag 98041 ccttcattaa gaattgtcac accatggtct cagtcaaaaa caccaacatt tttattggta 98101 ttgacaatta tgggaatatc caattccaag aagacaagga gacctctgaa cittctaaat 98161 gaagactcca atcttcctga tctgatggga agcagcttgg caagattacc aaccaccacc 98221 acagagagtg gactctaagc taagacttaa aagataagta gaaattatcc aggtaaagat 98281 gtgtacagag aaggaagtac atccagggga aaagaacaat acgtgcaaaa gtacggaaat 98341 ggtaaaaagt aatactacat agtcaaaqcc aagcagagtt cagaagggat ctggtggtga 98401 aaaatacggc tagagaaagc agcaaggatt ggcttctaaa acctatgtag tatcttggac 98461 cttaccctaa atgtaatgag aagcttctaa agaatctttc atttattcat tcattgaaca 98521 aatattttga ggctttctgt gaagaacatc attctaagta gtaaagatac agcagtgaat 98581 aggacacata aaatcctaga tctcacagaa ttgacattcc agagagggaa aggtagacaa 98641 taaatacata aacaaatcat ttaacaagat gatttcagac aatggtacgt actgtgaaaa 98701 aaatgaaaca aggtaatgga cagcgaaaag gcactggaag gaagcctgct tacctttgca 98761 tggttagaaa agatctctct aagaaagaga ccacatgtga gctgcgacct gaaggatacc 98821 gagaagctag gtgtgcaaag atgtggggac agaacttttg gactgaatag caaatacaaa 98881 tgcccttggg tgcaagcttt gcctgttcaa ggaccaaaaa gaaggccagt gtgcctgcag 98941 catactaagc acagaggaaa acactgttat atgctgagat tggaattata agtagagcca 99001 gataatatag tctcttatag gtcataataa ggcaaccaga ttttattcca agaggattta 99061 aaaatcactg gaggttttgc actagggtga gaggtgtgat ttgtattttt aaaagataat 99121 tctggagaat taactataat gaggtaggag taaactaagt taggggctat ttcagtggct 99181 cagacaagag ataatggtag cttagactag gatagtagtc gtagaaataa ataaaagtgg 99241 cactctactt tgggggtaga gtctataata ggtttggttt atggatcata tatgagagta 99301 aaaaaaagaa aataaattaa taatggttcc taggtttgta cctgagcaac tgaataaatg 99361 ggtgctgtga attgagataa aggagattga gaatcacagg ctttgttttg caaattaatt 99421 ttgagaggct tattagacat cccagtggag atttcaggtg agtggagccc attgaaaggt 99481 aagggacagg gtcaggtgtg gtaggtcagg cctgtgatcc caggactttg gaaggccaag 99541 gcagacagat cagttgagct caggagtttg agaccagcct gggcaacatg ggaaaaccct 99601 gtctctacaa aatatgcaaa atattacctg ggcatggtgg catatgactg tggtccaagc 99661 cacttggggg gctgagatgg gaggatcact tgagtacagg aggcggaggt tgcagtgagc 99721 caagatctcg ccactgcaaa ccagcttagg tgacagagtg agaacctgtc tcaataaata 99781 aataagaaac gtaagggaaa aggaaattaa tctgatcatt ggcaaatgca tagtatttaa 99841 agccagggga gtagatgaga tactcaaagt aggtgaagat aaggaggcaa tgaaggccta 99901 ggactctggt gtacatttag atggttataa gaggaataga aactggcaaa ataagtaaca 99961 ctgagcaccc aatgaggtgg agaggaaagc caggagatga agcatcatag aaggcaagag 100021 aagaagggtg tcaaagaggc gaggcagtca tcaacttctg ggcagtcaaa taatataagg 100081 acagaaaagt gaccattgga tttggaaata tgatgagcac tttgagtgga gtgttgagac 100141 agaagaccaa ttagagtaga ttgaggagat aacgagaaat gagaaaatgt aacctgcaag 100201 cacagacaat tcttgagaga cttttctgtg aaaggaaaca gacacagagt cttagcatgt 100261 cttgtctttc tatgggaaat gtaaatagtt tgagatcagg gatagtattt tattctgctt 100321 tttgtacctc tacattacct agcatagagc tagctaatgt gcacttaagt atgttctcaa 100381 ttcttatcgc ctgaatgact ggatgggtga aagaatggat ggatggatgg atggatggat 100441 ggaaggatgg atggatggat ggaagacttc tgatttgcca agaagaggat actggtagca 100501 gaaataaaaa cagcactgga gaaagaagag tttagatttt tattctttgg tgtcagttag 100561 acaggaaagt aagacattag aagagtcctt agataattta tgtaattgtt cacttaggat 100621 ttttaaatgt gatcactgat attggacatg ttcctagtga agcatttttg gtgtttcact 100681 ggttgaagtt aataactgta aaattatttc ccgttcagga cagaaaaaca gaaaacttga 100741 agctcctatt agaaagttca agattctctg gggttcttag gatttactgt tcccaaaact 100801 ctgtcaagaa caagaaaatg acctgtatac ttaactggtc taggcaacag tggaaagaca 100861 attctcagag aagatttgtt ttaagaagac actttccata ggaatcaaac aatagctttc 100921 agtgactaac atggtaagac acagggtgtt agctctttcc ttccaacctc atggctgttg 100981 taccttacct ttcgaccccg tgttcctgaa attgttaaat tcataaactt accaaggact 101041 aaccagcctc tggggaattg ctgtatactt agcaaactta caatggacat atttataagc 101101 cataatgata actgactaat aggaaatacc ctcaactgaa aatgagagat catcatttgc 101161 aaatgagttc ccttgcccag gcaactactg gggaaaatgt catgcaagca aaattaatct 101221 ttgaaatcct ccttttccat tttttgtgtc ttccttttcc ataggcacca gaaatatcat 101281 ggtgcctgga tctcatctct acagaaaaaa aaagtgat: gataaactga tttatattgt 101341 gtccaaatgt gattgtattt tcaaagataa cctaagggga gaatgctgtc tggcccaaca 101401 gcaggctctc gacttcattt cagacactgt ggccaatggc tgggaaacag gtatgaacag 101461 taggtttctg agtcccctgg aattattcca tttatgtagc cacctccatg acaggaagcc 101521 tccctactct tacttcccag tttgttcatt catggcacca ggttgcagat taaaatttgc 101581 tcagtgacct tttatctaat aatgtgttac cttcttctct taaaaagtac aagggacaaa 101641 tgctcatggt atacttttag gagattgtgg ctctctatta acagtattta ttcaacaaac 101701 atttattgag catttatatg tgcatcatgc tagggactgg aacctagtaa gtgtagcaca 101761 tattatttca tttaatcctc acaacaaacc catgaggttg gttttatgat cccaattttt 101821 cagaagaaga aactgatatt cagaaccagt taactaacta gttcaaggtc atgcaatttc 101881 taagatacag aaccaagagt caaagacatg attttaaacc aaagcttttt ctgctactcc 101941 acattgcttc cctaggtgag atctgaggca ttccgcgaaa agagaagggt cataaagcca WO 00/09525 PCTIUS99/17712 EPI-109 995 102001 agggaagaca aqcttaggaa aaaaaaggga aatgtcctaa ataaacagct ttcctattta 102061 ccagaaacca ctagtttaaa aatataatgg gaaaaatcct attcacttta acaatgttaa 102121 aaaaaaaaaa gatagaagaa acatagggat aaacttaaca catttgtagg atatgtaaag 102181 aaactaaaag atgttaataa tggcctaaag aaaaaaaaac ttacatgtat ggggagatag 102241 accatcttac tggattctaa tatttaatag tctaggtgtt ccatttctca ccaaattaat 102301 gtatacattt aatacaatgt caaacgaaat atcttaggaa ttgcttacaa attgtcagat 102361 aattacaaag tttacctggg aaatataagc atatatgaag agtgaatggg accccaccac 102421 tccccccaaa acaaaaaagg tctgaaaagg acagaaatca aggagagtct tgcctgccag 102481 atacaaaatt ctattataaa ggtgtattga tgaaaacaat ttaatactag tgtagcaata 102541 ggcagcaaag caatgaaaca gcataaaaag accagaacta tacctaatta tgatgaagat 102601 ttaaggtatg ataaacatga cataattcaa atcagcagaa attggcatag atagggttaa 102661 gacaaatagc taatcattag aggggaggaa gqaaaggagg gaggataaaa ttaggttcct 102721 gccttcatct tacattaaaa taaattccag atgtattaca tttaaatttt tttaaaaaaa 102781 gaaaccacaa aatacttgaa gaaaatataa gttgttatat agtcttttga tgggaatttt 102841 tttttttttc agagacaggg tcttgctctg tcacctagcc tagagtgcaa tggcatgatc 102901 atggctcact gcagccttga actcctgggc tcaagtgatc ctcccagctc agccccccag 102961 gtagcaggaa ctacaggcat gcgacacccc atccaactta ttttttattt tttgtagaga 103021 caggggtctt gctttgtttc ccaggcttat ctcgaacttc tgccttcaag cacctcagcc 103081 tcccaaagag ctgggctgat gggacatttt ttaacatagt gccacattac cataaatgaa 103141 aagcttgtaa aatactaatt tttaaaacta atatatatca gaaattttta taaacaaagt 103201 taaaaagcaa acacaaaaaa tttgtagcac ttatgacaaa tatatgtata tatatgaata 103261 caaaaagagc ctttacaaaa cagtaagaaa acaatgaata ctcccaatgg agtattcaaa 103321 actaaactgc taaaagcaat tcaaaacaaa aaacataaac tatgcatata tgtatgtgaa 103381 aaagtttaac cttatcaaag aagtaaactc tcaaagaaat aaacatcaaa taaggaaata 103441 gccttttccc acaaataacc aaaatctgta agaatactga gctgcgaatg tttcagaaaa 103501 aaaaaaaaat catacaccta gttcggcatg taattaatat agatcaqaac actttaaaaa 103561 tatttatagg ccaggcacgg tggctcatgc ctataatccc agcactttgg gaggccaagg 103621 cgggtggatc acctgaagtc aggagtttga gaccatcctg accaacatgg tgaaaccctg 103681 tctctactaa aaatacaaaa actagccagg catgttggcg tatgctggta atcctggcta 103741 ctcgggaggc tgaggcagga gaattgcttg aacccaggag gtggaggttg cagtgagctg 103801 acattgtgcc actgtactcc agcctgggca acaagagcaa aactctgtct caaaaaataa 103861 taataaataa aaataaaata tttatatact ctgacccatc aatttgtcca gcataattag 103921 gcatgtgtac aagggtttac acacaagaat gcctattgca atattgcttt taatgctaaa 103981 aaaaattggg gaaaatgctt taaaaatata gattaagact gtacattgtg gtacagtcat 104041 ataatcaata gtatacagct attatttatt ttcagccact gtccaaaata tagcctggcc 104101 taacaacatt ctgttaggat acgcaagcac cgtgaggaga tcagctataa agtatcagtg 104161 tttcacacca ctgctccttt gctaataacc ttcaatggct tttaaagaag taaaaaacaa 104221 aggcaaaatt ccttagtcag cccttaagac tctctgttac ttagctcaaa ctaccctttt 104281 caacaacact gccctaacca ggatgagttt tttgcccccc tggagtacat tcagcctttc 104341 cttatcaaac cttcctttaa ataagtatct tctccaggac cacttcactt tcttccccaa 104401 tttagcattt tctatatctc caggcctacc tctataaagc ctgtcctaac cactcaaacc 104461 ctagcttttt ctctgaactg ctagaaatat ttttctctca ttggccattt aggtaaaaag 104521 gtttttactg tttattacct actcaataaa aattttcttt ttttgagaca aggtcttact 104581 ctgtcgccta gaatgggggg aagtggtgtg atcacaactc actgcagctt ctacctccca 104641 gctcaacagt cctcccacct cagcctagtg agtagctgtg actacaggca tgtgccacca 104701 taccccacta cttttcattt tttatttttt gtgagatgga atctcactat gttacccagg 104761 ctggtctgct gatctcaatt gatcctccca ctgtggcctc ccaaaatgct gggattacag 104821 gcatgagcca caatatctgg ccccagtaag cttttaaggc cattaacatg aggaacagtg 104881 ttctttacac tattttatca gctagggctt tgcatggagt aggagtttag taaatgcggt 104941 tgatgggtta atcaatgtgt gaaaatattc agagccacca aaaacagata ttatgtctat 105001 tctcatcaac aatcaaaatt gagtaaacag ccattttcta atacaggaaa ccacaaaaca 105061 ttgaatggtg acattaaaaa attcccccag caggagccaa ccaatttttt catcctgatc 105121 caagttagca aactgcaaaa gataggaagc actaatgagt ggaaatttga gtagaagcat 105181 ttcttatgaa ggctgtcttg actggatcac atttttattg ctgttggagg tgccaaatgt 105241 gtgtgtttat gctaatcctc cacctcaggc aacacacagt caaggatcct accaagtgtt 105301 accgtcaagt gtctgttggc agctcaaggc cccagcgttg ttcccttgca ctagggaaaa 105361 gacatattcc aggtacaagt actcccactt tgatgctaca gaggagttgc tgaactttgt 105421 gtcattaatc tctcttcgtt agatcccaac cctgtttaaa tcccactatc tgcctactct 105481 gggtcttcac caatttacta gatcatagtt ggagaaaatc tacaaagcct tgctcccttt 105541 agatttaaac aggtctccgt ttaaatttag aattgctaac ttcaagcggg cccttatgcg 105601 acagtatgcc tgtcagtcat actacatttc ctcaattcca ttcatgtgac tgctccatac 105661 ccttccctct ctcttcatac tactattatc tcttcccccc tccctcattt ttaactgatg 105721 atcttgtttc ctatttctct gagaaaatag aagccatcaa aagagagttt ccacaaactc 105781 ctactgcctt atctagccct gtaccatata ctttgcattt cctctcatta ccatggatgt 105841 actgcctatc tgtgcttcta tctaaggcta acccttccac ttcagttttg aatattatca 105901 gctcttacca actcaaggcc attgctctag caattctctc attctctctc attttcttcc 105961 atcaagtttt ccttttcttc aattaacaga gtagctccta aagggaaaaa aaagtcttct 106021 ttttcaatgc tcatcatcac tggccatcag agaaatgcaa atcaaaacca caatgagata 106081 tcatctcaca ccagttagaa tggcaatcat taaaaagtca ggaaacaaca ggtgctggag 106141 aggatgtgga gaaataggaa cacttttaca ctgttggtgg gactgtaaac tagttcaacc 106201 attgtggaag acagtgtggc gattcctcag ggatctagaa ttagaaatac catttgaccc 106261 agccatccca ttactgggta tatacccaaa ggattataaa caatgctgct ataaagacac 106321 atgcacacgt atgtttattg tggcactact cacaatagca aagacttgga accaacccaa 106381 acgtccaaca atgatagact ggattaagaa aatgtggcac atatacacca tggaatacta 106441 tgcagccata aaaaatgatg agttcatgtc ctttgtaggg acatggagga agctggaaac WO 00/09525 PCT/US99/17712 EPI-109 996 106501 catcactctc agcaaactat cacaaggaca aaaaaccaaa cactgcatgt tctcactcat 106561 aggtgggaat tgaacaatga gaacacttgg acacaggaag gggaacatca cccactgggg 106621 cctgttgtgg gatgagggga gtggggaggg atagcattag gagatatacc taatgttaaa 106681 tgatgagtta atgggtgcag cacaccaaca tagcacatgt atacatatgt aacaaacctg 106741 cacgttgtgc acatgtaccc taaaacttaa agtataataa aaaaatatat atatatatat 106801 aaaacaacta aaaataaatc ttctttttct gcaggatcag tccatcacca cacacacagg 106861 ctgtgtttta tgttgttccc cagcttaaga gatcgttctc cagatcccac tgctccttcc 106921 agttgtcacc tcagttctcc acttcttttt gctgataaac tactctaact agttacatat 106981 gatttctgtc cccaggtccc ctccctcagt tgttttgaac ataatcattt atatcattta 107041 tcattttcac tctaattgca caaccaaaaa ctcccttttt ttttagatgg agtctcactc 107101 tgtcacctag gctggagtgc agtggcatga tctcggctca ctccaacctc cgcctcacgg 107161 gttcaagtga tccccctgcc ttagcctcct gaatagctgg gattatacac atgcaccacc 107221 acacctggct aattgctttg tttttgtttg tgtgtgtgtg tgtttttttt tttttttgga 107281 cagagtctca ctctgttgcc caggctagac tgcagtggca tgatctcagc tcactgcaac 107341 ctccacctcc tgggttcaag cgattctcct gcctcagcct cccgagtagc tgggactaca 107401 ggcatgcacc accatgccag gctaattttt ttgtattttc agtagagacc aggtttcacc 107461 atgttggtca ggctggtctt gaactcctga cctcaaatga tctgcgcacc tggacctccc 107521 aaagtgctgg gattacagac ttgagctact gcgccgggct attttgtgtt tttagtaaag 107581 acggggtttc accatgttgt ccaggctggt ctcaaactcc tgacctcaag tgatccgctc 107641 gcctcaggcc ctcaaagtgc tgggattaca ggagtgagcc accatgcctg gccataaaac 107701 tgccctttgt taatatgact gttggcctgc acattgtcaa atccagtggc attcatctta 107761 ctcggccaac ctacggcatt tgacactgtc tgtctttcct tctgttcctc tatctgtttc 107821 cagtatactg gcctggcttt ctttttacct cttttatatg ctcttccagt ctcaggctcc 107881 tttggggatt tgaaggtatg ttgcattttg ctattcaatg aataatgaca agtaatgatc 107941 acttaagaca ttaagtggtc agttccttta ctaggataaa aataattttc ttcccaacat 108001 ggggcatatt ccatttccag tctgactgtt ctgtgtaatc tttgtattcc ttggcagccc 108061 cttttatatc agttcatcta ctgtgcagga aattggacaa acatttgcac tggtataacc 108121 aaatacagtt gaacttttgg cttgactctt agctgaactc accaaaaata atttctgtaa 108181 gagactgaga cgtctacgag taggtttttc agaattagta aacataaatc aaggatacac 108241 aggtagattt gaatttcaga taaacaacaa atactttttt agtatgtcta ctgaaatatt 108301 tgtatcttat ctggcaattc tacctggtac agaactaatc cattctcttg aaagatcttg 108361 actctgtaat aagttctttg gtgatggaag ggaggtattt ctgtaattag agtcactgtc 108421 ttcctcccag ttttttatcc tggcccagat ctgcaatgaa cacacgacag aatccagggg 108481 ggatgaagat gggtgctttg caggaaaaaa aaattaaaaa catctgaaaa agcttttgta 108541 ctaaaagaat gtgatctaaa aaagaaagca ggagaacttt ctgtctgcac tttacatcag 108601 aacaaccttg gcgtctagaa gctgtgccct gtgggaagtg gtggtgcttg gtaagagatg 108661 ccaggaccag tggtacccac tgggagcact gccaataccc agcaaggagc atgggtgcac 108721 agtaaggcat tgcactgtga ttcagcataa aataacaata agggaacgtc acggagaaaa 108781 ggccagactt cctttgttta gaatgtggga aatgtcttct gaaaaatggt agtaaaaaag 108841 catgcttgga tggtccactc caggcaaaac tgactaatcg ggggtcaggg atacaacccc 108901 tgcatcatat gtttgtttct gttgggctga catgaggttc actgtgacca ctgtggttta 108961 accccatagt ctcctggaaa tacagccagg tcaagagagc tccacataaa acataatcaa 109021 aaaaataaac tcaagtttcc actgatcagc ttttcacaac tcttatcctt tcactaactt 109081 tggagcaaga tttgagaatt ggatggctat ttgagggcta tttctgcgct ttagttcaat 109141 gttttgttct ttctttatta gagaactatg gttttttatt atatttacac tttaagttct 109201 agggtacatg tgcacaacgt gcagatttgt tacacaggta taaatgtgcc atgttggttt 109261 gctgcaccca tcaactcgtc atttacatta ggtatttctc ctaatgctat ccctccccca 109321 gtcccccacc ccccgacagg ccctggtgtg tgatgttccc cttcctgtgt ccaagtgttc 109381 tgtttatgtg atagattacg tttattgatt tgtgtatgtt gaaccagcct tgcatcacag 109441 tcacttgctt acaagaaaca aacacttcac agatggatca ttatgtgtga taagtgaaat 109501 ccaaggattt atgctcagag gtgggcttaa caggtaggaa gagcagtatt ttccttcaac 109561 catgagtgta tgcaggtttt tcttttcttt tttgagatgg agtctcactc ttttacccag 109621 gctggcgcgc agtggtgcga tcttggctca ctgtaacctc tgccacctgg gttcaagcaa 109681 ttctcctgcc tcagcctccc aagtggctgg gattacaggc acctgccact gtctccggct 109741 aatttttgtc tttttagtag agatggggtt tcaccatctt ggccagcctt gtcttgaact 109801 cctgacctca tgaatcatcc ttctcagcct cccaaagtgc tgggattaca ggcatgagcc 109861 actgcgccca gcccacaggt ttttcaaaga ctaaacttaa aaaaaaaaaa aaaatttccc 109921 aatgaaatat aaaactaaag tgctaaactg tgatagactg ttttacaaga atgccagttt 109981 tcacaagtgt ctatagaaca tgtaatttag ataggtaaga tgaaattttg ataatatttg 110041 atggcaaatt taaacaggta tacaacaaaa ataaaattct aagcccctca accaactgaa 110101 tggactcctt ctctcagcca aaggaatacc aaagtaaacc tgaaaaacta gttttggcca 110161 ggattggggg taggtggggg aagcccaaca tgactcatta ttctctcctc cctttggaat 110221 tcaggcacaa ctgaatgtca gcattgacac taaaacacag atcttaagac tgacaagcca 110281 gactctttgt agcagagagc caggccctgg aagaaatcaa gttattttat cccaaaaaat 110341 atttctttga tatattttca aatggccctg caaagctgtc tcttgtgggg aaaattgaca 110401 tgctgtacag aatttccttc tctttccaag tttttactga tccaggagag atttaactaa 110461 gaggctagca tgtttttttt tttttttttt tgaggcggag tcttgctctg ttgcccaggc 110521 tggagtgcag tggcgtgatc tcagctcact gcaaccttcg cctcccgggt tcaagcgatt 110581 ctcctgcctc agcttcccga gtagctggga ttacagatcc atgccactat gcccagctaa 110641 tttttgtatt ttttgtagag acagggtttc accatgttgg ccaggctagt attgaactcc 110701 tgacctcgtg atccgcccac ctcggcctcc caaagtgctg gcattacagg cgtgagccac 110761 cgtgcccagc acaagacatt taccgtctat tctctctgaa gctactatct agaggcttca 110821 tcaacataat aagacccttg gtctccacaa ctccttatct tatcctatta gtttctactg 110881 attccaggtc tttagataat aacaactctt tcaaccaatt gccaatcaga aagtctttga 110941 atccacctat gacttaaaag ccccactcct tcaagttatc ccgcctttct ggactgaacc WO 00/09525 PCTIUS99/17712 EPI-109 997 111001 aatgtacacc ttatatgtgt tgatggatat ctgcctgtaa cttccattcc cctaaaatgt 111061 ataacatcaa gctgtaaccc aaccaccttg ggcacatgtt ttcaggaact catgagactg 111121 tgttgcagac cttggtcact catatttggc tcacagtaaa cttctttaaa tattgtatag 111181 agtttggctt ttttcattga cacaggaaaa ataaagaatt ggaaggtctt tcatcagtca 111241 ctgagccagc ttcatatctg actgaggtca tacagttcag tgatttgtag ctttgctact 111301 tagattgcta tccattatct agaagcatca ggatcacgtg ggacctattg gaaatgcaga 111361 ctttcctcct agaacccagg accttggaat attcttggca catagtaggt gctcaataca 111421 tattgaactc ctaggtgcaa ttcattaatt catgaattaa tgaattaaca cgctctcaaa 111481 gtttagtgct ttttcacaga ctagtctttc tgcctcttaa gcactcagct caccacgctt 111541 ccagtctcac tcccctatta gtctgattaa aatctgctta catgtgagtc tgagatcaag 111601 tgttatctct tctgagaagt cttccctcac tggcccaaag gaatttctcc tctattttag 111661 cactgtccca gttgacttgt cattattcta gtctttttca tattagttgt ttttcatata 111721 tatgttatta aggaaactag tcatttcccc taatagaaca aaattgctgg cctttggggt 111781 tggcaatgga ggggaggctc ttcttgaaaa gggggaagag tgttctccta atatttttct 111841 tacgagattt atgttgctca tctttagcct ttagtccccc attgcctgcc tacagttggc 111901 agagaccatc tgttctctca ctgtcaggaa ctgtctcaat tcttgaagtt cagagtcaaa 111961 aaagaagcaa gttttcctag ctctttgatc aactttcaaa gttttacttc catttgaaaa 112021 tttactaagt caccaggaga tggtttatac tgagaaatat ccactcatac tcttcctctt 112081 caactttctt ccatatacac cctattacag ggatatagtc ttactctata gctcaaaagg 112141 atgaccctat cagaaacctg cacagtatgt aaaacattct caccagaggt tcacttgtgt 112201 atttccaccc tagaatggaa gctctacaaa agcacagaat gtatcatttt aactttagat 112261 tctattttca cacccagtgc ttgacacatg atttgaagtt aatatttatt tatcaagtga 112321 ttgttttaaa atcatgactc actcaacaaa gttataagaa taagaatagt gttacagaat 112381 tggtatacac aagctgacca taatcaacac acctattatc atttttttgc gacaggttct 112441 cgctgtctca ccctggctgg agtggagtgg catgaccacg gttcactgca ggtttgaact 112501 tccaggctca agcaatcctc ccacctcagc ctcccacata gctgagccca caggtgtgtg 112561 ccaccatgtc cagctaactt tttaattctt tgtagagaca gggtcaccct atgttgccca 112621 agctggtctt gaactccttg gctagagaga tcctccctcc aaggtccccc aaaatgctgg 112681 gatctcaggc aagagccacc atgcctggcc ataatcaata cacttttaag aatgctagaa 112741 tgttatatca gatgcatact tcagcactat ctcaagcaaa ctggggtgtg ggttattcta 112801 catataaagt tcagcagtgt tgttccacag tcccaaactc caactgaggt caaatgtagg 112861 gtgcagcaag gtcactgggg ctgtcatcaa gggcctctcc ttgcactctt gccaaccctg 112921 tttcttgatt gtctctacca ccatgagtca ccagcaatct cccacagtca cttgtttaaa 112981 agttcacaag tattgtgtga attgcaggca accccttgac tccctgattg cctggtcttc 113041 ttccttgggc tctaccattt tttttcccca gcactctttc tgctgctcta aattttaatt 113101 catgcaattc catatgtgtt tctctatcat tcttcatctc tttcctctcc cttccatcca 113161 attttgtttg tctgtttgct tgcttgcttg ctttaataca tttctctttt tctgagaagg 113221 cttgagtcca aaactctcag ttacctgttg ttctgtttcc cgttagttaa tctccgaacc 113281 ttcataaatt aaatctgaca aagtcccctg actaacaaag gaaatgcaca agtcacagta 113341 aaaggggcac acacagaaca caaatagacc cagggtcttt tctgttcatc actcagcttt 113401 ttataggaga tccaggagaa atgaagtgga aagggaagtg tgttgagtta ctatacaaca 113461 caagagtaaa ctttcttata agtggtaatt tttttttaca ggaataattg aaaatggaaa 113521 ttaccttctc tactcatagt aagtactcag tgcgttcttg atgggatgag aatgtgtttg 113581 agctttagtg taaggcagaa ttctgtttag tctgccagta ttggagaaaa ataaaacaca 113641 aagggactga catgtaggaa gtggcacctg ggagggtctc aattcttcct attacaaaaa 113701 tgccccagag aaataaaaag cttgtgtaca tgttgagatg ggagagttct ctggcccccc 113761 tcgcaggatg tgtgacagtg gggtggctct ctgctgcgcc accatgagct caaacccctc 113821 ataggagggg gagcacacag gcaggaaggt gcaggagctg ggcgagctct ttgggctctg 113881 gccccgtggt actgtctaga ggtgggtgcc tgcaactcct gaaagcccaa gtgggcatgt 113941 gttacagtgc actctttcag ctttgctgtc tgcagcttaa gcgttaacca gctcagtttc 114001 ttcttggtac ccaggtcctt gtctggcatc caggaagaat caggttacac atggacttga 114061 aggatgaatg tgggagtttt atggagtggt ggaggtggct ctcagtggga tggatgggga 114121 gctggaaggg ggatggagtg ggaagatgat attctcctgg agtttggctg tccagcagcc 114181 gatctcctct ccagtcgtcc ccagcctctc gacgttcaga tgctcctctt ctctccttct 114241 ctgccatgct gttctgccgt tcatctgcct gtctctctct ggagcctgga atttggggtt 114301 tatatggtac acaataaggg gcatggcagg ccaaaaggga actttttagg tgcaaaaaac 114361 aggaatgcct cttctcactt agggctatag attttcaggc ttgaaggtgg ggcctttacc 114421 agcgaacctg tatttccctg tctcctgtgc atatcaatgt aatcaaatac tgggctgatc 114481 caggatgttt ctttagacca attatgggta aaataattta cattcaggtt tttatatttg 114541 cttttgtcat ttctttttaa gcaatcatgt aaaatatcta tacgacagta atagatgata 114601 gcgaacctaa ttaaaattac cagaaactta agaatctcta atgatttCaa ctgtaactaa 114661 ggttatttct ctttatgttg aacaatgttg ggagataaga cacaagagtt tctgaagtat 114721 ttcagaaaca caaagaggga ggttatataa ataatatttt tttcctactt tgggaaaatg 114781 aaagctagtc acaaagttaa acgagtggtt attttaatat ttaaaataca ggcttggatg 114841 tatttcctgt taaagaaaat aaaatgcaga atattcaaaa cgtctgacca cccttctaag 114901 aaaatgcatc tctgaggtat ttttccttag aagttattgt aaaaatcctg gagaagcttg 114961 aacacagcaa agcaaacagg atgcagagtt taatctgtgg aaagcttagg gaagaaaagc 115021 aaatcattaa aaataggtct tcctctgaag atttttaaaa cgcaaagagg gtggaatagc 115081 aatgataata aaaaagctgg catagagagt ggcacaattt gctgtgccac tgagctgact 115141 ggatgtgttc tgaatttcta ggcattagtg tacctttcca cacqcattct ccctttaaaa 115201 aaaatgccca cacactgaat acttttttca tgcaatttaa aataagcgca ccatctagtt 115261 tacagaaatt cactagaagt tatttatcct aaaatagcag agatctagaa gaattttgag 115321 ctctaggaca ttttagacac acagaaagaa gaatctggac aagtcttgac cagacatgac 115381 agaatagaaa tttcttttcc tatttatctc tttgaataaa attttcagga tcttacagtg 115441 gacaagtttg ttatctacac attgtgaagc acattgattt ctcctctgta gccttaggaa WO 00/09525 PCT/US99/17712 EPI-109 998 115501 gatctgagag gtgactaaqc tgattgaatg atccgtgacc gctctactgg gaccagtagt 115561 agaactttac tggtggagac ctgctggagg tttgagagca gactttgaaa attactagag 115621 ctacacagat actgtgtggc taactggatt atgtttagag gctttcagaa ctatgctgct 115681 gctgctgcag tgtagccagg acgcacagag aacatctaag gctcttgaat ggggcgatag 115741 ggacagattt cagcagccat ctgacttcag tgctcatttt gatgctttcc ctgcagggtg 115801 cagtgtgcag tgtgcagtgt gcagtggtgg gaggctcaca caggaatact tgcttctgta 115861 gccctaattt ccggttcaaa ctctgcattc accttgacag attctttcct tggccaaaat 115921 ttagttaggc ttctgggct tctcttatgc ccacctgcag actttttggt aaaatccagt 115981 tttagtaaag agctctgcta agtcagttta gcaagaatcc ccacctcaaa agtcactatc 116041 tccctccctg gtagtgtctg gcttgtcttc agcgagaatt ctattaggtt ctgttagatt 116101 agaatcctcc ttacccttga tgcttcctct tagtattttt tcatccactg actccttgac 116161 ccaccttgct cctcggctat aaattcccac ttgcccatac tctgcagtta agactatttt 116221 ctccccacta ctgcaaaatc ccattgccat ggtccctata ctatctcaat ggtaatgaat 116281 aaagtctgcc ttaccatgct ttaacaagta acattgaacc atttttttct ttaacaatct 116341 gctgcacaat gagattacta aaactttatt ccattttgcc atgctggatg tcctcaatgg 116401 aatggctctt gtgagcacca aatcattgtg agaaggaaaa cccatctctt acagccccct 116461 gtaacgtgat gtatgttaca tgtgatgtat gttacatagt tttttttcat gttgatcact 116521 ttttgcccat tttcctatat cttatcagtt ggaagactgt ggaagtttgt agtactaagc 116581 cacaagatga ctaagaagag ttgaaagggc aagtggggct aaaaacagat tttgtttgac 116641 ttaccccacc attcccccta tcatggggct gaatctgcct ggaggaagga gcatctttat 116701 ctttgtactg tgaaccacac agtctagcag cagcacagcc aaggcacttg gggtttcatg 116761 agactaagta catgcaattc tattgtaaag gcttaaaata atacaactg acccttgaac 116821 aacatgaatt tgaattgcat ggtcagttat acgcagattt tcttccacct ctgccacccc 116881 tgagacagta agatcaatca atcctcttcc tcctactcct cagtctactc aaagatactt 116941 gaagtctact tgaagatgac aagcacaaag acatttatga tgatccactt ccacttagtg 117001 aatagtaaat atgttttctc ttcctcctaa ttttttaaca ctttcttctc tctagcttaa 117061 tttattgtta agaatacaat ctataataca tatgacatac aaaatatgtc ttagttgact 117121 gtttatgtta tctgtaaggc ttcaggtcaa gagtatgcta ttagtggtta agttttcgag 117181 gagtcaaaag gtgtatgtgg actttcaact gcaggggggt gggcacccct gcccccatgt 117241 tgttcaaggg tcaactttac tgccaaaggc aagcctttac atccactttt tccatcccat 117301 cagtaaatgg aaaaagatag ctacagtatc cctgcgtcaa atcttttttt ttgcagatca 117361 caaattggcc actcaccttg ctctgtgagg ggtaaaatgc cccactttct ttagtaatat 117421 ttaagttaga taatatttaa gttataaagt tgttctttgt aatcgttaat tgtaattttt 117481 acatagtttc tttcaaacag aaatagcatt tttgttagat aacctcccgt atagatgatg 117541 aaactccttt taagggctat ctgaatttta attccttgaa aaggcagaaa ttggatagct 117601 agtagtcata aatgtactgt ggcttccccc aaccatctgg gctatataga agctgcatcc 117661 ttggactgca gtagaggagt cttacaaagc acagagcaac ttctctcctg ggttgcgcta 117721 gttatgatgg caattttaaa tgtgtacttt tacccaaaga aaatccttat tatcaacaat 117781 cacaatgcca tcataaccat ggtataaaaa attcaaaatg tcccagctga agtggaggca 117841 aagactcaag ttcatggagt cagagtttcc ttgctattcc tctttttcaa atgaccattt 117901 agtaagcacc tgaagaaaat actatggacg gcattgaaaa gtgaagatag gtttaatctt 117961 ctcgaaaatc taattctcca gatgaaacgc tgacacttat ccaccccaca gaccctatag 118021 cagatgtgtc actggccatc acatttgaca cagagaagtc ataactcagt cagcacagag 118081 acatttccat gagtttctga accatggaca gaacgtcgtc tgtgggacat gaaaactgga 118141 acttagagga caggcacatc tgagaaatgg gcagtttaaa ggcagaacat agcacatatg 118201 tgactgggtt ttagaagcaa atttacaaga cgcactcttc ttcatcctaa ataatctgca 118261 accaaagctt ccaaaaaaga caatttagga atgcagaggt gaggagtagg gaggggaatg 118321 ggatgagaga gagtggagat taatggtggg cagagcgagg tttagaactt agtggtttct 118381 tcaggttctg aactgaaatt tgtatactgt aaaggcacaa acaccatttt taacaaaagt 118441 gagcaggact tcctatctgg ttcagaaaat aggtgaataa atagtacgaa ttattaaaaa 118501 taataatttc cacttataca taggaaactt gataggaacc atgataaatg cttaactctt 118561 aatcttcaag gaactctgct agggatataa tattataaat cttgttttgc agatggagaa 118621 attgaatttt aacccaagtt atcataaccc ttaaatgatt aaatgatact gttacatgag 118681 aaagctgcgt atctgtttcc tggatttgta gccataattt gtgtctcaag tcccttttgc 118741 tgccagctat cttgggtagg tgtgttccct ttgggctgtt tgataccccc acatttatct 118801 tttttttttc tctttttttg ttgagagagt ctttccctgt tgcctaggct ggagggcaat 118861 ggcgcgatct cggctcactg caacctccgc ctcctgggtt caagtgcttc tcacgattct 118921 cttgtcccag cctctctaat agctcggatt actggcatgc accaccacgc ccacctaatt 118981 ttgtattttt agtagacaag gggtttctcc atgttggtca gggtggtctc aaactcctga 119041 cctcaggtga tctgcctgcc ttggcctccc aaagtgctgg gattacaggt gtgagccacc 119101 atgcctggcc ccaaatttat ctttaatgcc ccaaattatc tagttcccat gactgggctt 119161 ctgctttgat cctttctgca cttgctggac cctctccctg ggaaatgaga ttgtgtcctg 119221 agcccctagt tagaggctat gtctctgctg ttcctgaatg ggcctcctgg atgagacctc 119281 attaaaagtc taattctctc ggagaattga gagataccta tttgtctcaa aatcattgaa 119341 accaattaat gtattatgag cctctatcca gtgatttgta cctcaattcc ccaatccagc 119401 tgtcaaggcc aatttgttct accttaccta gtaggtaagt ctggaattgt agctgtggca 119461 ttttcagtaa tggtactcta ggttagcagt ccccaacctt tttggcacca gggaccagtt 119521 ttgtggaaga caatttttcc atgaagggct gggcagggga gtggtttcag gatgaaactg 119581 ttccacctca gatcatcagg cattagattc tcacaaggag tgcgcaagct agatccctca 119641 cacatgcagt tcacaatagg gtgtgcactc ccatgagaat ctaacaccgc tgctgatctg 119701 acaggagaca gagctcaggc agtaatactc atttgcctac cgctcacctc ctgccgtgca 119761 gctcagttcc taacaggcca cggaccagta ctggtccacg gcgcaggcat cagggacccc 119821 tgttgctagg tataagcaac tggctgctgc atgtcttctg tgtagctaca tctgtatgtg 119881 tatctgatga gatataaatt atttgattat aaattacttt cttcatatta gagttgtgaa 119941 tgagtatcac atataattat acataaacta ggaatatgct ttttaataat gtatataagt WO 00/09525 PCT/US99/17712 EPI-109 999 120001 aagtttcctt aactataact ttcatcttag cgtagtaaga gggtgctaag aaatatttgt 120061 gatgaaaata ggcattgata gagttgagac cactgggtga tgaaagagtg taaagatttt 120121 aaagccttca gatgctggtt caaggtgaga aatgtgattg ggagcaaatc aattaacttc 120181 ttgaagtctt atagggcagt tatgaatact taatgttaac atatgtaaag ctcttctgcc 120241 ctgtatacag taaatgctag ttagctatta tgatcactac taaaatgggg atgacataaa 120301 cctcataagg ttttaagrat tatgcaagat actatacaaa gtccagtaaa tatcacattc 120361 aattgaatcc atgatgtccg attattttag ctacttccaa gagagaaaaa aatgctgtca 120421 gttttactgt tcttataqag agcaaggcag atcccaattc ccaatgtggt aacgtgaaaa 120481 tttttgcatt tgaatcaaca aaacactttc tcctttcttt cctactattt aacaactggt 120541 aagtctatac tcccccaaat ctggaattct cctttcttat tctttttcct cctaccaaga 120601 ccgcaggatc ttttacttgg ctataagggg taaacctcaa gtagtacaag ttctctgtat 120661 tacttttata ctctgtcaca gattcccttt gtttcctcat ctccatgtga atttagttaa 120721 attctcagca ttctgatcct tactatacaa ggtaaatgaa tataaaaaca aaacgaaaca 120781 aaaacctctt cctatttaca taaggcccca acctaatatt tagtgatata tattaatgtg 120841 aacaaggaac taacgaagac tgggaagaaa ttcacagact tgagagaaga aatggcagga 120901 tttcctggga acaatttcat gtaacgtcaa aggtggtaaa aggtcaaata gaatgaagat 120961 ggagaatacc ggattttctt acaaaatgat ttcccaggag atctcatcaa atgcacgagg 121021 ataccttctc agtttcacct agtgagtaaa agactggtaa catagctcac ttacaatttg 121081 gataaacaaa actaaacaaa caacatcaaa atttcagaaa aaataatagc aaaacagaaa 121141 tcaaacactc aaatttttgg tccttctgtt tatttcattt tggatactca gtgaatgtta 121201 attaaccagg aaacttaaaa gttatttcaa ttatgaacct cttcaatcct tcatcaatta 121261 ttttgagtat tctggtctta aaaacatctc tttcttctac aaacttctga aagagatgaa 121321 cacctccacc tacaccaaaa taatgtgctt tgctggccaa aagtacacgt ccatttttac 121381 ttaacagtct aaggaaaatc tggtgcaaat tactataata atctgggttg taaatggttt 121441 ctgaggtgag aatgagatca tattttacaa aaagtttttc actacttagt acaagcttac 121501 aaaactcaga ccactcacca gaaaaaaatc ggcatttata tagttgtgtt acttttggtt 121561 tcctgcatct tttcacatct ggctcattta catcattttc ttcatcttcc aaagtggagt 121621 tagctactac attaggtaag gttacttcat caatcaccat actgttataa tcttgaaagt 121681 gaatttcttt ggaccctccc ttgaatgcag ttatacctag taaacctgat ccacaaccaa 121741 gatccaagac ttttttccca gcaaatttca ctttggcctt tgtgaaataa gccaggaggt 121801 caaaggtaca ttcccagatt tttaagcctc cctcataaac acctgtaatc agatcagagt 121861 gagaagaaaa qctttttgaa actatgtttt ctccagggaa gttctctttc aacaagatgg 121921 ttttcactac tgataactta acatgctgga aacctggtaa tgtttctatg actttatttt 121981 ctaacatctt ctttaaatct ttaggcatag catgctcttt ggcagctctc aaggagggct 122041 gttttccatg tggctccaag ttccttgaac tgctggctgc actgagtgga ctgtctgtgt 122101 cttgagaggg agctgcattt tccattgact tatgttccca caagtgatcc tgaggcaagt 122161 caaattgttc tgcagaacat tttctgtccc tctcttctcc tttttgactt tctgaqactg 122221 acagctcttt tgaggaatcc agggtcaaag ctccatctct aatgggtgtt aattcatttt 122281 ccagatggtc ttctatagtg aaattaaact gaaaggtcat cctcttatta aatgcacaca 122341 atctttaaat tcagattctt caacttctgg atagaatttg atgatacaca caaatctgcc 122401 tcaattattc aattagtttt gttgggccca atttctcttt agcagcttat acatggtaac 122461 aaatatttag agatatttcc aaatgacttt ttagacgtct ttggtcctct ttccaagcag 122521 ctctggaaag aaaaaaaaaa aaaaaagaaa gaaaatgatg attaaagcaa aatggcacat 122581 ttcactaaag tgtaatatta aacagccacc cccacccctc cctgtcccac catacagctg 122641 ctttttctta aaaagttgtg gggaagagag agagataaga gatttggaca ctcatacaca 122701 ccttaagggt tccaaagtgg gagaagaaaa tcaactataa aaacaaacag aagaacaaca 122761 gcaaccacca ccactaccac ctggacaaac ataaagtcca agatattcag acaggacagc 122821 ctagctactt gctgtctttc agctgtcttg atttgtgtcc aaccatattc accccctaag 122881 cttccagaat aacttcactt ctgtctttta cagaagaggt gcagtatttt attttggtaa 122941 gtcagcgtcc ctttaaaaac atgcataggt atggcctggt gtgtgtaaat tcatccaaga 123001 cttcactcca aacatttagt cgagaacagc agccctaagt gtatagaagt gggggtaatt 123061 tggcaataat tagtaaaqac taattcggtg gcagagcaaa cgcaaactag ggcactgcag 123121 tagtttggag agacctgtag aaataagaag caactttatt gagaatcttc tatctactgc 123181 gctagacact ataccatctg cctcaatttt cacagttctg gcaagtggga tctttgttcc 123241 ctttatacaa gatttacaat ttgggggaga ggcgggtcac ccagtcccgc ggctaggaac 123301 gcgcctcttt cctctcccat cacgctgcaa ggcttggagt cacttccggc tgcaggtccc 123361 ggaacaaatc cgaccccaga agtggggact tctggccctc acctccccat ttgaatgtaa 123421 tgtttacagt gatccagacc tggggatgct tgcttcccga cgtgtcctgg gatcgcgctt 123481 ctgaaaaagc tcacctcaca acgcctcctc cggacctaaa tcgcgcacca gtgagtcgag 123541 tcctccaggg gctagagaag cccgactttc tttccggcct tgagggaccc gggctcacca 123601 agaaaccagc cgccctcctc tctatggttt tggagccggc ggagagcgcg caagggttgg 123661 cgggactgcg agtttccggt ctgggctttg gcgggtctgg tttgaagctc tcctgtttga 123721 cgaaagtatg tctcaggaag gtgcggtccc agctagcgcg gttcccctgg aagaattaag 123781 tagctggcca gaggagctat gccgccggga actgccgtcc gtcctgcccc gactcctcat 123841 atccttcctt ggttgtcact tctacctaga gaagggtgtg ggcgggtcgc gaacctttct 123901 cttctgtccc ttcagaccca ccgccaggct gggttatatt accgcggcct gaaccccctc 123961 ttttctttgt cagtgagtgg gatgaaaagt gagggactgg aggggaagcg acaaccgtgg 124021 tagatttaag taaggctttg gccctggaaa gcctcgcgga cgtgttctga cccaaggttt 124081 tagcagtgga tgtggcgttt tcttccattc cttctttcag tttttctgta ctcgttgctt 124141 gcaattaagt gtaaatactt ttgctagtgg ataatggggg aggcaaggac tgagacctgc 124201 ggtatgacga tagctctggc tcttaatagt ttgaggtaaa gcgagatact ctgagctttt 124261 gtctcccgta aaaagggtgg tgaatatgaa taagggcttt cttagcgtta taagaattaa 124321 agggcatagt tctgtggtgt gaaatcttta aaagatgttc agtaaataaa aatgattttc 124381 ctccttcccc tctcagacct ctttttcttc tttctttctt tttttttgac aagttctcac 124441 tcctctcacc caggctggag tctttctgaa agagttcttc cgcttgttgt tggctttcaa WO 00/09525 PCT/US99/17712 EPI-109 1000 124501 ctgttggatt tgaggcgctt agcgccttct tcgtccgggt gcagcacatt cttgattggt 124561 ctcatgcctt tgtggttgta aatgtgcctg gaatcctagc ctttcatggt aaaccatatg 124621 tatatgtatc tttttcacaa catttgagcc cagctttata caattacact caaaagaaaa 124681 aaagtaacct tcacttgaga gaatctcaat actgcacaaa tattgtgcag ctaaagccct 124741 atgtaatcac atagaagtca ttcacctagg cattagcaaa atctcagaag gtgccaaagc 124801 cccctttttt agtttttgtg taggtacaga actgccgtct tcaaggagtt tcaacttgaa 124861 aacaaatagc caccctcaaa acattcaaaa acacttaaac tgcgtgcata atgtgtgtga 124921 gacatggtgt taggctttgg gagaacagag acacggaacg tgattcctct tcttccccac 124981 aagcttatag agagacttca ttaagttgaa agtcaacatt cccacctagc tttgcacttc 125041 aaacgacata ttcaaaaaag cccaaacttc ctctagtttt cttcatctga gtaaatggtt 125101 tcacaaactg aaaccttgaa tcctctctgt ctcacacacc cgatcagtaa gttctattgt 125161 ttctgattcc aaactatgtc ttgaatcaat ccgtttatct ccatcctcat tgctaccact 125221 ctgattccaa acccttatca cctctcactt ggagtattaa tagtttcctt gtttctactc 125281 ataattcatt attccaaaaa agttaagagg ggaaaaacat agatctcgtc atttcccttt 125341 ttaaaccact ttaccttcaa ggttccaggt gatctaagcc ttgcccttct ctcataccta 125401 gttaattaac tacactctgt tcatgaatac attaggctca cctacctcaa gatctttttg 125461 ctcagcctga tttgttctct cagccttttg catatttcat gtttatgtct tggcccaaat 125521 gtcacttcct tagaggggct ttttcagagc cttcaatctt aggcagttcc cccaaacgca 125581 gtcttacact tgtatcacat tggcctgttc agttttctaa aaagcacatt accattaaaa 125641 gaaatgctct tgtttgcttt gtatattttc cacttctaca cattatgttg caaagttcat 125701 aaaggcagga tgttgatttt cttcacagcg ttaccctcag cacctagaac agtgcctgac 125761 acatagtaag cattcattaa agggctaaaa atatttcatg ttttaaaaat acttgggagt 125821 ctaattagac aatacttttt ttcagcttaa tggtagtatt ttagcttcac tattttaaca 125881 aatgaaaaat ttgcaataaa tctacaatgc cattaccccc caaaatcttt ttcatgtttt 125941 gcattttacg tattattttc caggccttac ctgcatgtct gcataatcat aactgactaa 126001 ttttggaaca gctggtaatt atttgagctt tactgaaatt ttttcatgag gccaattcta 126061 ccctactgaa ctcaaatttg agttaatgat gacctcattt tgattgctgc tgtaaaaaat 126121 aagatttcgg aagaggaatg aattcttgta ttactgtggt aggactatgg gttttttttt 126181 gtttgtttgt ttgttttgag acggagtctc accctgtcac ccaggctgga gtgcagtggt 126241 gcgatctcag ctcacagcag ccaggttcaa gtgattctcc ttcctcagcc tcccgagtag 126301 ctgagattac aggcaegtgc caccatgccc ggctaatttt ttgtatcttt agtagagatg 126361 gtttcaccat gttggccagg ctggtctcga actcctgacc tcgtgatccg cctgcctcag 126421 cctcccaaag tgctgggact acaggcgtga gccaccgtgc ccggccgggt tattcatttt 126481 tcttattaac attctttgat gattcttatg gtgttgttac agtaaaacat ttctaacaat 126541 tattctaaca attattcttg atggtgtata tgaagaattt attgtcgtgt atttgtaagc 126601 tgctatgtgc agaagaattt cagtcaaata aagttggtaa gataggtatg taagtaatat 126661 gaaaaaagat agaaggtgat gagtgactta ggtataaatt aagtacaata gaaatgttga 126721 ggaaagaaaa atttcttgta atagaaatcg gaagtacaaa ctgggcatgg tggtgtgcat 126781 ctctaatccc agctccttga gaggctggta tgggaggatc actttagccc aggagcttga 126841 ggctgcagtg aggtgtgatc atgtcaccgc actccatcct gggtgacagc aagaccgtct 126901 ctcttttttt ttttttttga gacggagtct cgcctatgct ggagtgcaat ggcgcgatct 126961 tggctcactg caacctctgc ctcccagttt caagtgattc tcctgcctca gcctcctgag 127021 cagctgggat tacaggtgtg cgccaccatg cccagctaat tattttgtat tttaagtaga 127081 gacgggttct caccatactg gccaggctgg tcttcaactc ctgacctctt gttcgcccat 127141 ctaggtctcc caaagtgctg ggattacagg tgtgagccac cccacttggc cccgagcgag 127201 accctctctc taaaaaaaaa taaataaata aatcataaac ctgtggatta ttgtagcatt 127261 gtttctcatc tgtcaaaaat atttcatgac tatgcatagt ttgaaaaggc aagtttgtcc 127321 ctgggcaatt ttcaaaatat ttctttaatg tgttttcaca atactgttta cctaataaat 127381 cttaagtttt taaaagcaaa attaagccag taatttgagt ccaattccaa tctcttatga 127441 gtcattgctt aaatttcaaa agggttttat ttttttttta ggtttgttct gagtaatgaa 127501 taccctatta ctatgatact agtatcttcc ttaattatcc tactcattgt ctcaacattc 127561 tgacagttgg attgagcata ttcgtaagta aaattgtttt aactgtatga tgtactttga 127621 tgttaaggtc cgagtcccca catacctcgg tagatgtgtt cttacagttt tgtattccct 127681 tgaaatgtaa ctgttctcta tgttacagcc tttataacct tcagttactt gaaatgaaca 127741 aattcattca aattccagca cttaaaagtt ttaaattaca ttttggataa ataccaaagt 127801 gttttgttga tgatgtatgt ataaacaaat tgtaaatatt aaacgttagt tgttacgatt 127861 agacctatat aaaacatgat atgcagtcta ctgaatagct atcagcctct aacatgttta 127921 gtgtcattta gaaaatgctt tctaaattgc caaaagctga ttgtctaggt gataacaaat 127981 ttaccatttg gaggaagttg actttctcat tttcatgtct tcatcagtct tacttgatga 128041 gattcattct tctagtcaga agagagttta gactgctcag tttactcata ttttgagtta 128101 gcttttctat ttagagttca cttggttgtg gaatattcat ttataatttg aatctacgtt 128161 gtgtaatggg acctaatttt tttttccttt gtttttgttg gagtctcgtt ttgtcaccca 128221 ggttggagtg cagtggcgtq atctttgctc actgcaacct ccaccttcca ggttcaggtg 128281 attctcctgc ctcagtctcc caagtagctg ggattacagg catgcttcac cacgcctggc 128341 taatttttgt atttttagta gagatggggt ttcaccatgt tggccaggct ggtctcaaaa 128401' ctcctgagct caagtgatcc tcctgccttg gcctccataa gtgctgggat tacaggcgtg 128461 agccgctgag cctggcccca gagtttgttt tgttttgttt tcaagacaag atctcactct 128521 attgcccagg ctggagagca gtagtgcgat catagctcac tgcagcctga actcctgggt 128581 tcaagctatt ctcctgcctc catcttctaa agtgctgtga ttacaggtct gagccatgat 128641 gcttggcctg tgtttttgtt tgtttgtttt gggggacagg gtcttgcttt gtcaccaaaa 128701 ctggagtgta gtggtgcgaa catagctagc tcactgcagc ctccatctcc cacgctcaag 128761 caatcctctc acctcagcct tccaagtagc tgagaccgca ggtgcgtgct accatgcgtg 128821 gctaattttc tatttatata tttatttttt ggtagacatg aggtcttgtc atgtttccca 128881 ggtggtcttt aactcctggg ctcagacagt cctcccgcct cagccaccca aagtgttggg 128941 attacaggcg tgagccacca tgcgtggcat aatttttttt aagtaaatta tttttttatc WO 00/09525 PCT/US99/17712 EPI-109 1001 129001 ttgagtatag aagtgattca tgttcattgt ggaaaatatg aaacatatag aaaaacagaa 129061 aagattacaa aacatctaat ctgaaatggt taagattttg atgagaacag tctcatctca 129121 tttccgtata ttcctgccag cctatccatc attcttcgta catgtttatc tacattaaaa 129181 ttggtgttat attttggaaa ctttttgttt aactacattg tgaacatttt tcatgtttta 129241 aaatgtcatt ttaatgatgg cagatcctat tcaatagatg tacacacacc tatttaactg 129301 gtccacaatt gttggatatg taggtcgttt cctttctctc tttttttttt tttttggcta 129361 ctacttaata gtttctctgt atagaatgtg gtattttgaa agtgtatcaa gctttagatt 129421 ggtagtattc ttgcatttaa taaagggcag tggcctttgt tgactgacat gacaatattt 129481 ttataaaatt tgttatttgc tttacagaaa ttttgaaaat tattgtagaa atgtttttac 129541 ctcatatgaa ccacctgaca ttggaacaga ctttcttttc acaagtgtta ccaaaggtat 129601 aatactatta cctgaaaata catgttataa ggaatctagc ctcagtctta gatgatttat 129661 tattaattat ggctctcttt ttctaatata tcaaatatat tcaaaataaa aataaggagt 129721 aagtagatct catgtgagac tataatggtg ttagtgtgat cattaggcag ttaaaaactg 129781 ttacaggctg ggcacggtgg ctcatgcctg taatcccagc tctctgagag gctgaggtgg 129841 gcagatcatc tgaggtcagg agttcgagac cacccatggt caacatgatg aaacctcgtc 129901 tctactaaaa gtacaaaaaa ttagctggac atggtggcag gtgcctgtaa tcccagctac 129961 ttgggagact gagacaggag aattgcttga gcctgggagg cggaggttgc attgagtcaa 130021 gatcgtgcca ttgcactcca gcctgggcaa taagagcgat gctccgtctc aaaaaaaaaa 130081 aaaaaaaaaa aagaacttat attttcagat tgtgtggttc ctttactaac tgaatttaaa 130141 ttatttgtag tcaattttaa atgctcttgt attttaaagc cactgtactc cagcctgggt 130201 gacagagtga aacccttaat tcaaaaaaaa aaaaaaaaaa aagaaaagct ggaatattgg 130261 caaaatcaag taactaagag aaaacattaa attcacagaa tacattatta cattttagat 130321 atatatggta tatgttttct ctgaaaagca caagcatacc ttttttgttt taaatggagg 130381 gaactaaaga tactttggtg ccaaaatgaa acattatttg taattaatct cttattgaaa 130441 tgggtttcta actttagctt tgaatcgtaa tctttcaaat ttcttgtact catagtcact 130501 tgatgattct ctatctgaaa tatttcttag aatttgttct tgaccaccag aaaaagattc 130561 aactgttaca tagatgaaaa tggatgttga gtgttaacag gcctatggga aacagtattt 130621 tctttagcta cattgtattg ttgactgtgt tgctattctt ataatgttta ggtcatttaa 130681 attgttagaa agatccaagt attaagatct agggtggcta acttttcaca gacaaaaagc 130741 ttgtttgtaa ggtcatttac tataccctta attcaggaag gttagcttga attgggtcaa 130801 aaggaaactg gttagaaaat aagtgagtag tgaataggcg attcagtgca aattccttcc 130861 agaaaatacc cttgtaaatg actgtatgaa tgtggattct tcaagacagt caaatttatt 130921 gtgcgaaagt aatactttta ttttttgcat ctctaaaaca tgaactttga gtgatttttt 130981 aaaaaaattg atgctattaa atagattcaa accatagaaa tggaaaataa atttctgttt 131041 ggggcttttg gggggattat gttgtaaaaa taccttttct ctgtattttg tgcttaatta 131101 ggtacaattg ttaagctaga tgatagcctg tggatgttac tagtgcaaaa tcaaattatc 131161 gtattgtgtt ttctctgtaa agttttgtct tgtcttttct agtgatttct cttattcctg 131221 tttattactt gatttgtttt tacagactgt gaaattattc gatgacatga tgtatgaatt 131281 aaccagtcaa gccagaggac tgtcaagcca aaatttggaa atccagacca ctctaaggaa 131341 tattttacaa gtaagtcaaa tgtattagaa agcaggagag agagggagct taaagaatgt 131401 caaaattttt atactgatac tgattagcta tgtattctta tgtaatggcc taatgttgga 131461 attaaattta tagaattaaa gacgtgaata tagaaacatg aattctgaat aataaactct 131521 tataagaaga gaagtcatca agctagctga ccctacctgt attttcaagg atatgtgtgg 131581 aacacctgcc atgtgttttg aagtttgtgt tagtattcta aatggctaga cagttgttcc 131641 agtatttgta gttctgatag actaaagttc tgtgaaaaga ggaagagact gtgttttgtt 131701 cattgctgta tttgtagcac ccagcatgct gactaatacc ttttcagtgc acaaaaaata 131761 tattctaagt gaaatttcct tccttattca cagacaatgg tgcagctctt aggagctctc 131821 acaggatgtg ttcagcatat ctgtgccaca caggaatcca tcattttgga aaatattcag 131881 agtctcccct cctcagtcct tcatataatt aaaagcacat ttgtgcattg taaggtgagt 131941 aaaggtctaa ttatactttg aatggtatat aatcaatgtg cataggggct gagtaaaata 132001 atgtttgtat aagattttac attttagtct atattattga aataaacttt tccatagaat 132061 aaagaacatg taagtaaata attgttgcaa aaaaagtggt tttaaggaag tcattaaaag 132121 tggctttttg gggtttttta gttttatctt atttcccctc tataaagaaa gaagttttaa 132181 gaatttgtgt tgagacagac acagggatcc tgaaatagtt atgtcatgtt gcattgacca 132241 atattcaatt accattatga ttagatgtca gaacttcctt ttataaagga aagttaatcc 132301 ttatttagtc catctctaca tgccagaggt agccttgagg cacaaaagct tgcctagaat 132361 ttatgggtca cagacagttt taatattgct atttgttggg cgaatgaaaa tcactagtta 132421 attaatacct ctctttgctg ataggatgct aaaaatgtca cgcacctggc ctaatgttac 132481 ccttttttag ttctgtattt gcaagatcat ggaagtcaga aataatattt tatacatgct 132541 tgcatctctt gaagcacact atatttaatg gatgttcact aaacaatgaa tgaatatgtg 132601 attcagtaaa tttatgatct ctaatagtat gaattaaagt aaatttggct cttgagcttt 132661 gatttgtttt ttctctcatt tttatttatc cgtaatcaga atagtgaatc tgtgtattct 132721 gggtgtttac acctagtttc agaccttctc caggctcttt tcaaggaggc ctattctctt 132781 caaaagcagt taatggaact gctggacatg gtttgcatgg accctttagt agatgacaat 132841 gatgatattt tgaatatggt aataggtgag tgaagaaaac tttctgctta gtatatggtg 132901 actataaatc atgtatcaat taaaattgtc tctaatgatt catgttattt tcttactaat 132961 tatgcattaa aattgattta aatcttacca aataaattt taatcttgaa atttggaatt 133021 tgtaaaattt attttgggta ccttaaccta gatttgcgta tttagttact gtaatttctc 133081 cacaatgatt aacttatata actttataat ctctgaggtt gtccatattc agagacaata 133141 actttcacat ttttttaacc ataactgata ttgagatgca gtttatattt ccttccagaa 133201 tacatataaa tacgtgcata tgtgtatgta aatatgtcta ttctcatata catattataa 133261 tgaaataact cattttacat gtgatgcact ttatactagt ttatttttat tttattttat 133321 ttttttgaga cagagtctca ctgtgtagcc caggctggag tgcagtggca caatctcggc 133381 tcactgcaac ctcgcctccc ggactcaagc gattctcctg cctcagcctc atgagtagct WO 00/09525 PCTIUS99/I7712 EPI-109 1002 133441 gggattataq gcgtccacca ccacacccgg ctaatttttg tatttttagt agagacaggg 133501 tttcaccgtg ttggccaagc tggtcttgaa ctcctgacct caggtaatcc acctgcctca 133561 gcctcccaaa gtgctgggat tacaggcatg agccaccgtg cccagccaat actagtttat 133621 ttttaaagaa ttgctggtcg taacacactt cattgatttt atcactcatt aatggattat 133681 gaacaagagt ttgaaaaaca atataaaggc aaagtttgca ttcaaaactt tggtataaag 133741 agagtaagtt ggttttgtgc agtgtatcag gcacctgttg ctctgcaaca caccacctca 133801 aaatctattt attcactatt tatttattca tgattctgtg agtctgcagt ttagggtggg 133861 atgtcctgag acaactttct ctgatccacc tggggcacta gctcacccat gtgacttcag 133921 tgacttcatt cacatctagc tgttggcaga ggcagaagta cttgagaaag ccatgtgcat 133981 catccagcag gttcacccta tctcagatac ctgatgccag tggtttcagg gtttctaaga 134041 gtagcaaaag tgtgagcagg tcgctgtgtg ctagcacttt tcaagtttct gcttgcctta 134101 attttattat tgtcccccgg gccacagcag gtcatagcgt ttagcccaga gtcattgtag 134161 aaaagtgtgg attcacaaag ggcagtcatt gtggccattt ttataaataa tctaccacag 134221 actgagtaaa agccttgcat gaataccatg gatattaatt tgaattcttc ctttttagat 134281 tttctttcct tagcaatttg ttttgtcatt ttggattaga attatatctg tagaatattt 134341 cagttataat agggtacaac ttttattcca ctgaacatct ttagttttat ttaggtcatc 134401 tggtaggtat aaacttcaga agttaatatt caatatttat aaaaaccatt aacaagtgtg 134461 acacttaaat agtttaaata attcttttga cacaactgtt tccaagttgt gttacgtatt 134521 ttaattcaat caaatgttga aattgttcag tagatagttt taattatagg agaaactcac 134581 ccccatgaca tttggatgtc ttaaaagttc tgttatcttt ctttgcagtt attcattctt 134641 tattggatat ctgctctgtt atttccagta tggaccatgc atttcatgcc aatacttgga 134701 agtttataat taagtaagtt tgtttgttat tttttacttt ttagaaaatg ttttccatat 134761 tccccaatct taattattca tgattcttta gattgcattt aaaacatttt gtgtgaattt 134821 aatgttcact gacactgctg tctgataatc cagatattct acatgtagct ctcaagccaa 134881 attggacttc tttaccctgt ggcctctaaa attaaaaaaa atgttcttcc tagttagcta 134941 gtacttcaga aataatgggc catgggccag acragaactt aaccactttt cttctgctac 135001 tgttgtttaa ccagctatca agtatcctat ttctaggatt agataaattg ataactataa 135061 ttaaaactga atataatctt ttcattaggt acttttaagt tgttcacact taattccatt 135121 tgtacagtaa ttttaacttt ctgaaactga agcattttaa agggtcacca gggatagtgc 135181 ctgtagcatt catcagattc ttaggggtga gaggagatgt ggttgagatg taaaaatggt 135241 taagaatatc tactttatac acatacataa aacattaaag gtcagtgtat tttcaggtct 135301 taggtacttt tcttgtacta ccaggacatt aagttgccat tcagtggtta agagtgttgc 135361 ctgggagctg tatcacatgt gcttaaatcc attcttgaaa tcatttactc cttctgagcc 135421 cttgggctat ttggttaatt tctctgaacg ttagtttgct catctgaaaa tggaaataat 135481 aatagcaact tcttgacagg gttatagtga gaattgagtt catcactgtg aaatgcttag 135541 aaatgtgcat gacacatagt taatactcaa ggaattagcc acatcactat catcatcact 135601 gattatcttc cactcttacc ctcttccagt tcattttctg cccagcagaa tgatctttta 135661 aaaagtaaat cagatcatgt tactctattg cttgaagtct atcccatttg attaagaata 135721 acaacctaat cctctgtgga tgctgcctcc ttcaccagcc tgtctcatgc tgctctccct 135781 actcttagtt cctcaaacat accaaactct cctgtcccag agtcttttcg tggtttttcc 135841 atctgcctag gatgcttctc tctcctattt tgtgtacctt gctaactcct gcttactgtc 135901 tttcagttct cagcttaaga gttatatctt catgataaca ttctttgata tccttaccct 135961 aagattaagt tagattgata tccttaccct aagaataagt tagattaggt ctctctattg 136021 tagcacctta gactctgtca tttgacaaat cacagcccta attaattatt cttaaaatta 136081 tttaacattc tctctcatgc tagaccacaa gtttcatgca ggtaaggcgg agattgtgtc 136141 catttgtttg acccctttgt ctccagggcc tggtagaatg cctcatacat agtaagaatt 136201 caattaatat tttacacaga gaaaaaatta gcaacttatt taaacaaata taactgcttc 136261 agaggtaaac tgggcacatc ttagttatat tatgtgatat atgatgcttt ttgattgttt 136321 ttttaaatgt tctacaaggc agatattgtt agaggtccta agttacttga tgtgttactt 136381 gtggtgattg tattcttttc tttttattca tttaggcaga gccttaagca ccagtccata 136441 ataaaaagcc agttgaaaca caaagatata attactagct tgtgtgaaga cattcttttc 136501 tccttccatt cttgtttaca gttagctgag cagatgacac agtcagatgc acaggtaaaa 136561 tttgggctaa tagcatttta aacagcaact cttattttct ttggcagtta gtaaatctca 136621 tttgaatgtc tgggtcagtc tatttaagag gattttaatt tatttcattt gggtgttttt 136681 ttttgatctg tgggattatt tatatcccat aattactttt cacccagagc attgtattag 136741 attcctaact gcigtcattg cctctggggt ctgcctggct ccctctttgc ttggtaactg 136801 gttggtcaca gcattcttct cagaatcctt tcattctttt ctgcatgaga acaaaaattc 136861 ttttgttcat atttgtataa gatctgatat agctgcaatc aatcttgcat tttttcttca 136921 ccaacgcatt gcgaccttta gggatacaag tatgtttgtg catgtatatg tatgtatcag 136981 tcttttaaat ttgatatagt catacatttg tttttatttt gaaaagttag agtgttgaat 137041 tggtatccca tttatgaaac attatattct aaaaatttgt agtacgatta ttgggaatta 137101 taactcattt tcctgtaaca ctgttataca tagtaccttt tgctttcaga ctagccctca 137161 attttattta actatagtag tcctaaatta taagattaat agtactcagg acctaacagt 137221 tatatgtcat ttgttttttt tttttttgag atggcgtctc actctgtcac ccaagctgga 137281 gtgcagtggt atgaccttgg ctcactgcag cctctgcctc acgggttcaa gggatcgttc 137341 tgccttagcc tcctgagtag ctgggattat aggcgcctgc caccacgcct ggctaatttt 137401 tttagtagag acggggtttc gccatgttgg ccaggctggt ctcgaactcc tgacctcagg 137461 tggtccaccc gccttggcct cccaaagtgc tgggattaca ggtgtgagcc accgcgccca 137521 gcctatatgt aataatttta atgggaccat gaattgaata tttcttcctt gaatagcaat 137581 gacatagccc cttctattgt acatctgcaa gctgatacag ggaattcctt tgtacctgcg 137641 ctcttccctg ccagtcagct atgggggtga aagtgtaggg gttcatccaa gtcctaaaac 137701 tggtagcaac tcctagggca gggctgatct ggaaggacag accctagggg agggtggaac 137761 tttaaaaaga agttctgaag gtagtaagaa ggaaatgagg agtagtgtta ggaaggggct 137821 aacttttttc ttcttgcttc tcttctttat ctcacctgcc cctccccttg tatcccttct 137881 tcctttttcc ctttcctttt ttgtcctcac ttcattcgtg catcctttct gattcctctt WO 00/09525 PCTUS99/17712 EPI-109 1003 137941 accttgctaa aaggagaagt ttgtttgggt atcctatatc aatggcagga aggttgtttt 138001 cttctttacc tttatcczat agattcatat tctcaacacc aacctcctcc tttttcagtt 138061 tccttcttgc ttctcttgac accacagagt ttgcagctag tacttggaga ggaaaattaa 138121 acagagatac ttggaccaag agtaagatga agaaagtcta aacaacagta tagtctatag 138181 tggcaagaga gagtatgggg gctgcttagc cagggtggct gtacataaag tatatcttca 138241 gtttatataa actgcttata gatggaaatc agaaaattta aattctctta actgtccaag 138301 aaaattctca ttttttcaaa tttgggactg ataaatgtga ccagttctgc ttactgtcca 138361 ttgcctgaaa tggagctttg aggtggactg tataatttct tcaatcttaa ctccaaattc 138421 tgatcagcga cgccctctgc tgttcactat taatatttat ttaccaatca aagtaaagta 138481 ttgaagtttt cctggcagtt ttcactttgt gttttagtcc atttaggctg ctataacaaa 138541 atcccttaaa ctgggtaagg gattataaat attagaaatt tatctctcac agttctggaa 138601 gctgggaagc ccaatatcaa ggcaccagta gatttggtgt ctaacgaggg tgtgccgtct 138661 gcttcaaaaa tggccccttg ttgctgcatc ctcacttagt gcaaggggca agacagctcc 138721 cttcaacctc ttttataagg gcacttatgt cattcatgag ggcagagccc tcatgactta 138781 atcacttccc caaaggcccc acctcttaat agtatcacat tgggtgttag gtgtctggga 138841 ggacaccaat cttcaagcca tatcatctca cttggaaaaa agtcaaaata aaaccagtag 138901 atttaattaa tattacacta tttatagaag catgtgatgt atcattcctt gtattaattt 138961 cctggggttg ccgtaacaag ttaccacaaa ctaggtggct taaaacaata gaattttatt 139021 ctctcacatt tctagaggca gaagttcaca gtgtgtcaat agggccatgt tctctggaag 139081 gctttagggg agaatatatt tcatatcttt ctcttagctt ctcggtgtca ctggcaatcc 139141 ttagcttact ttggctttct gtgtcttcac atcatctttt tataagaaca ccagtgatag 139201 tgattaaggg cataccttac tttaatatga cctcatctta actaattatg tcttcaataa 139261 ccctatttcc aaataaggcc acattctgaa gtattgggag ttagaactta aagctttttg 139321 ggagggacac agttcaaccc ataacaaccc ctaaaatcga tatttattct caattaagtc 139381 ttgaaattgg tttcaaaaag agaatattct attagagttt ttaatgtata gttttaacat 139441 atagttcttt agcccccaat tttttttttt tttttttttt tttttttttt tttttgagac 139501 ggagtctcgc tctgtcgccc aggccggact gcggactgca gtggcgcaat ctcggctcac 139561 tgcaagctcc gcttcccggg ttcacgccat tcccctgcct cagcctcccg agtagctggg 139621 actacaggcg cctgccaccg cgcccggcta atttttttgt atttttagta gagacggggt 139681 ttcaccttgt tagccaggat ggtctcgatc tcctgacctc atgatccacc cgcctcggcc 139741 tcccaaagtg ctgggattac aggcgtgagc caccgcgccc ggcctgccc caattattta 139801 gtttttctat aaacagggaa atttatttgt gtggccctta gaactaattt aatttccact 139861 ctaattccta cttatgttta tataatgctt ttagaaattt gtattattca gaaaataaac 139921 atatactatt gtatctgttg cctacactta gattttattg cctgctatat ttaaatttta 139981 ttagtatttt aattgtttta ttaaagaaag aatgtgcctg taatctcagc acttttgaga 140041 ggccaaggca gaaggattgc ttgagcccag gagtttgaga ccagactgag caacacaggg 140101 agacccccat ctctacaaaa aataaaaaaa ttctccaggc ctcatggcac atacctgtag 140161 ttctagttac ttgggagact ggggtgggag gatgcattga gcccaggaga ttgaggctgc 140221 agtgagccat gatcaggcca ctgtactcca gcttggacaa cagagtgaga gcttgtctag 140281 atagatagat agatagataa tctaaataga taatagacag attatctaaa tagataatag 140341 acagattatc taaatagata atagacagat tatctaaata gataatagac agattatcta 140401 aatagataat agacagatta tctaaataga taatagacag attatctatc taaatagata 140461 atagattatc taaatagata atagatagat agattagata gatagataga tagatagagc 140521 ttggacaaca gagtgagagc ctgtctagat agatagaaac aaagaaagaa agaaagaatg 140581 gtgctcatat tttaaagcat tgaaaaatgg tcttccttgc ttatattacc cacaccttct 140641 ttgttggcat taagatgcaa actttgtttt aaacagttga gtaaatcaaa gatgggactg 140701 ttaagttatt tgtgttattt acctgctttt tgaaaatgta aaaataaaac tctaggttta 140761 attagtagta tgctatttag taatgaagta aagctagagg cttcgaacaa atcttgtgta 140821 atttcctctt gaatgagaga gaaaatttaa agtaagcaaa caaataagtt gtgtgtcacc 140881 actcattcag tcatttaaca agtatttcca gagtacttat tctgtgccag gaaatgttgt 140941 aggtgccctc aacaacttag agtctagcct gagacacaag taagtaggta attattatag 141001 aatggtatga tctttggagg actgggtatt ggctggctca tgggagtaca agataggtac 141061 ccagtgatga agtcaggaaa ggtttcttat ggtgatatga tgacgtctat gctgattata 141121 aggtcagtgt agaataaact ttgtgctttt aaatttgcat agcactgtat tagagagttc 141181 atcttcaaaa taatcgaaaa ggctgagtgt ggtgacccat ggctgtaatc ccagcacttt 141241 gggaggccga ggtgggcaga ttgcttgagc taggagttcg agaccaggct ggccaacatg 141301 gtgaaacccc gtctctacta aaaatacaaa aattagccag gagtgatggt gcgcacctgt 141361 aatgccagct acttgggagg ctgaggcagg aggatcactt gaacccagga ggtggaggtt 141421 gaagtaagcc gaggtcatgc cactgcactc cagcctgggc aacagagtga gactccatct 141481 caaaaaaaaa aaaaatgatc aaagaaaggt gaattttcat ctaccctatt tctgctgagg 141541 aaaatggact attttcaaat atttttaata agggtcaaaa tgagggatc (2) INFORMATION FOR SEQ ID NO:2720: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: _base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2720 1 atttttttgt agagacaggg tctctctatg ttgcccaggc tggtttcaaa ctcccaggct 61 caagcaatcc tcctgccttg gcctcccaaa gtgctggcat tacaggcgtg agccactgcg 121 cctggcccgt attaatgttt agaacacgaa ttccaggagg caggctaagt ctattcagct 181 tgttcatatg cttgggccaa cccaagaaac aagtgggtga caaatggcac cttttggata 241 gtggtattga ctttgaaagt ttgggtcagg aagctgggga ggaagggtgg gcaggctgtg WO 00/09525 PCTJS99/17712 EPI-109 1004 301 ggcagtcctg ggcggaagac caggcagggc tatgtgctca ctgagcctcc gccctcttcc 361 tttgaatctc tgatagactt ctgcctccta cttctccttt tctgcccttc tttgctttgg 421 tggcttcctt gtggttcctc agtggtgcct gcaacccctg gttcacctcc ttccaggttc 481 tggctccttc cagccatggc tctcagagtc cttctgttaa caggtgcatg ggg (2) INFORMATION FOR SEQ ID NO:2721: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2721 1 gaattccgtg gttcctcagt ggtgcctgca acccctggtt cacctccttc caggttctgg 61 ctccttccag ccatggctct cagagtcctt ctgttaacag ccttgacctt atgtcatggg 121 ttcaacttgg acactgaaaa cgcaatgacc ttccaagaga acgcaagggg cttcgggcag 181 agcgtggtcc agcttcaggg atccagggtg gtggttggag ccccccagga gatagtggct 241 gccaaccaaa ggggcagcct ctaccagtgc gactacagca caggctcatg cgagcccatc 301 cgcctgcagg tccccgtgga ggccgtgaac atgtccctgg gcctgtccct ggcagccacc 361 accagccccc ctcagctgct ggcctgtggt cccaccgtgc accagacttg cagtgagaac 421 acgtatgtga aagggctctg cttcctgttt ggatccaacc tacggcagca gccccagaag 481 ttcccagagg ccctccgagg gtgtcctcaa gaggatagtg acattgcctt cttgattgat 541 ggctctggta gcatcatccc acatgacttt cggcggatga aggagtttgt ctcaactgtg 601 atggagcaat taaaaaagtc caaaaccttg ttctctttga tgcagtactc tgaagaattc 661 cggattcact ttaccttcaa agagttccag aacaacccta acccaagatc actggtgaag 721 ccaataacgc agctgcttgg gcggacacac acggccacgg gcatccgcaa agcggtacga 781 gagctgttta acatcaccaa cggagcccga aagaatgcct ttaagatcct agttgtcatc 841 acggatggag aaaagtttgg cgatcccttg ggatatgagg atgtcatccc tgaggcagac 901 agagagggag tcattcgcta cgtcattggg gtgggagatg ccttccgcag tgagaaatcc 961 cgccaagagc ttaataccat cgcatccaag ccgcctcgtg atcacgtgtt ccaggtgaat 1021 aactttgagg ctctgaagac cattcagaac cagcttcggg agaagatctt tgcgatcgag 1081 ggtactcaga caggaagtag cagctccttt gagcatgaga tgtctcagga aggcttcagc 1141 gctgccatca cctctaatgg ccccttgctg agcactgtgg ggagctatga ctgggctggt 1201 ggagtctttc tatatacatc aaaggagaaa agcaccttca tcaacatgac cagagtggat 1261 tcagacatga atgatgctta cttgggttat gctgccgcca tcatcttacg gaaccgggtg 1321 caaagcctgg ttctgggggc acctcgatat cagcacatcg gcctggtagc gatgttcagg 1381 cagaacactg gcatgtggga gtccaacgct aatgtcaagg gcacccagat cggcgcctac 1441 ttcggggcct ccctctgctc cgtggacgtg gacagcaacg gcagcaccga cctggtcctc 1501 atcggggccc cccattacta cgagcagacc cgagggggcc aggtgtccgt gtgccccttg 1561 cccagggggc agagggctcg gtggcagtgt gatgctgttc tctacgggga gcagggccaa 1621 ccctggggcc gctttggggc agccctaaca gtgctggggg acgtaaatgg ggacaagctg 1681 acggacgtgg ccattggggc cccaggagag gaggacaacc ggggtgctgt ttacctgttt 1741 cacggaacct caggatctgg catcagcccc tcccatagcc agcggatagc aggctccaag 1801 ctctctccca ggctccagta ttttggtcag tcactgagtg ggggccagga cctcacaatg 1861 gatggactgg tagacctgac tgtaggagcc caggggcacg tgctgctgct caggtcccag 1921 ccagtactga gagtcaaggc aatcatggag ttcaatccca gggaagtggc aaggaatgta 1981 tttgagtgta atgatcaggt ggtgaaaggc aaggaagccg gagaggtcag agtctgcctc 2041 catgtccaga agagcacacg ggatcggcta agagaaggac agatccagag tgttgtgact 2101 tatgacctgg ctctggactc cggccgccca cattcccgcg ccgtcttcaa tgagacaaag 2161 aacagcacac gcagacagac acaggtcttg gggctgaccc agacttgtga gaccctgaaa 2221 ctacagttgc cgaattgcat cgaggaccca gtgagcccca ttgtgctgcg cctgaacttc 2281 tctctggtgg gaacgccatt gtctgctttc gggaacctcc ggccagtgct ggcggaggat 2341 gctcagagac tcttcacagc cttgtttccc tttgagaaga attgtggcaa tgacaacatc 2401 tgccaggatg acctcagcat caccttcagt ttcatgagcc tggactgcct cgtggtgggt 2461 gggccccggg agttcaacgt gacagtgact gtgagaaatg atggtgagga ctcctacagg 2521 acacaggtca ccttcttctt cccgcttgac ctgtcctacc ggaaggtgtc cacactccag 2581 aaccagcgct cacagcgatc ctggcgcctg gcctgtgagt ctgcctcctc caccgaagtg 2641 tctggggcct tgaagagcac cagctgcagc ataaaccacc ccatcttccc ggaaaactca 2701 gaggtcacct ttaatatcac gtttgatgta gactctaagg cttcccttgg aaacaaactg 2761 ctcctcaagg ccaatgtgac cagtgagaac aacatgccca gaaccaacaa aaccgaattc 2821 caactggagc tgccggtgaa atatgctgtc tacatggtgg tcaccagcca tggggtctcc 2881 actaaatatc tcaacttcac ggcctcagag aataccagtc gggtcatgca gcatcaatat 2941 caggtcagca acctggggca gaggagcctc cccatcagcc tggtgttctt ggtgcccgtc 3001 cggctgaacc agactgtcat atgggaccgc ccccaggtca ccttctccga gaacctctcg 3061 agtacgtgcc acaccaagga gcgcttgccc tctcactccg actttctggc tgagcttcgg 3121 aaggcccccg tggtgaactg ctccatcgct gtctgccaga gaatccagtg tgacatcccg 3181 ttctttggca tccaggaaga attcaatgct accctcaaag gcaacctctc gtttgactgg 3241 tacatcaaga cctcgcataa ccacctcctg atcgtgagca cagctgagat cttgtttaac 3301 gattccgtgt tcaccctgct gccgggacag ggggcgtttg tgaggtccca gacggagacc 3361 aaagtggagc cgttcgaggt ccccaacccc ctgccgctca tcgtgggcag ctctgtcggg WO 00/09525 PCT/US99/17712 EPI-109 1005 3421 ggactgctgc cctggccct catcaccgcc gcgctgtaca agctcggctt cttcaagcgg 3481 caatacaagg acatgatgag tgaagggggt cccccggggg ccgaacccca gtagcggctc 3541 cttcccgaca gagctgcctc tcggtggcca gcaggactct gcccagacca cacgtagccc 3601 ccaggctgct ggacacgtcg gacagcgaag tatccccgac aggacgggct tgggcttcca 3661 tttgtgtgtg tgcaagtgtg tatgtgcgtg tgtgcgagtg tgtgcaagtg tctgtgtgca 3721 agtgtgtgca cgtgtgcgtg tgcgtgcatg tgcactcgca cgcccatgtg tgagtgtgtg 3781 caagtatgtg agtgtgtcca gtgtgtgtgc gtgtgtccat gtgtgtgcag tgtgtgcatg 3841 tgtgcgagtg tgtgcatgtg tgtgctcagg ggctgtggct cacgtgtgtg actcagagtg 3901 tctctggcgt gtgggtaggt gacggcagcg tagcctctcc ggcagaaggg aactgcctgg 3961 gctcccttgt gcgtgggtaa gccgctgctg ggttttcctc cgggagaggg gacggtcaat 4021 cctgtgggtg aagagagagg gaaacacagc agcatctctc cactgaaaga agtgggactt 4081 cccgtcgcct gcgagcctgc ggcctgctgg agcctgcgca gcttggatgg atactccatg 4141 agaaaagccg tgggtggaac caggagcctc ctccacacca gcgctgatgc ccaataaaga 4201 tgcccactga ggaatcatga agcttccttt ctggattcat ttattatttc aatgtgactt 4261 taattttttg gatggataag cctgtctatg gtacaaaaat cacaaggcat tcaagtgtac 4321 agtgaaaagt ctccctttcc agatattcaa gtcacctcct taaaggtagt caagattgtg 4381 ttttgaggtt tccttcagac agattccagg cgatgtgcaa gtgtatgcac gtgtgcacac 4441 accacacaca tacacacaca caagcttttt tacacaaatg gtagcatact ttatattggt 4501 ctgtatcttg ctttttttca ccaatatttc tcagacatcg gttcatatta agacataaat 4561 tactttttca ttcttttata ccgctgcata gtattccatt gtgtgagtgt accataatgt 4621 atttaaccag tcttcttttg atatactatt ttcatctctt gttattgcat ctgctgagtt 4681 aataaatcaa atatatgtca aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa (2) INFORMATION FOR SEQ ID NO:2722: (i( SEQUENCE CHARACTERISTICS: (A) LENGTH: _base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2722 1 ggttcaagtg attctgctgc ctcagcctcc caggcgggac tacaggtgcc tgccaccacg 61 cctggctaat ttttttgtct ttttagtaaa gatgaggttt caccatgttg ggcaggctgg 121 tttcaattgc tgacctcaag tgagccaccc cgcctcagcc tccaaaatgc taggattaca 181 ggcatgagcc accgcaccca gccaagtttg tacatatatt tttgactaca cttcttaact 241 attcttagga taaattacta gaagtgaaaa ttcttgggtg aagagcttga ggcctttaca 301 cacacacaca cacacacaca cacacacaca caaataggct ggatcgagtg gctcacacct 361 gtaatctcag cagtttggga ggctgaggaa ggaggatcac ttgagtccag gaggttgaga 421 atagcctgaa caacatagca agatcttgtc tctacaaaaa agtttaaaaa aaattagctg 481 gccatggcag catgtgcctg tagtaccagc tactcggaag gctgaggtag gaggatcgct 541 tgagcccagg aggtgattga agctgcagtg agctgtgatt acaccactgc actccagcct 601 gggcaacaga gctagactct gtctctaaaa aaaggcacaa aataatattt aaaaagcacc 661 aggtatgcct gtacttgagt tgtctttgtt gatggctaca aatgagacag ctctggctga 721 agggcggctt ccatttccat gggctggagg aggacattt gcaaagtgtg ttttcaggaa 781 gacacagagt tttacctcct acacttgttt gatctgtatt aatgtttgct tatttattta 841 tttaattttt tttttgagac agagtctcac tctgtcacct gggctggagt gcagtggcat 901 tattgaggct cattgcagtc tcagactcct gagctcaaac aatcctcctg cctcagcctc 961 tggagtagct aggactacag gcatgtgcca ccatgcctgg ctaatttttt aaatgtattt 1021 ttttgtagag tcggggtctc cctatgttgc ccaggctgga gtgcagtggt gtgatcctag 1081 ctcactgcag cctggacctc gggctcaaga aattctcaca cctcagcctg tccagtagca 1141 ggggctacag gcgcgcacca ccatcccagc taattaaaaa tatttttttg tagagacagg 1201 gtctctctat gttgcccagg ctggtttcaa actcccaggc tcaagcaatc ctcctgcctt 1261 gcctcccaaa tgacatcgga ttacaggcgt gagccactga gcctggcccg tattaatgtt 1321 tagaacacga attccaggag gcaggctaag tctattcagc ttgttcatat gcttgggcca 1381 acccaagaaa caagtgggtg acaaatggca ccttttggat agtggtattg actttgaaag 1441 tttgggtcag gagctgggga ggaagggtgg gcaggctgg ggcagtcctg ggcggaagac 1501 caggcagggc tatgtgctca ctgagcctcc gccctcttcc tttgaatctc tgatagactt 1561 ctgcctccta cttctccttt tctgcccttc tttgctttgg tggcttcctt gtggttcctc 1621 agtggtgcct gcaaccctgg ttcactcttc caggttctgg ctccttccag ccatggctct 1681 cagagtcctt ctgttaacag gtgcatgggg gtggggtggg ggactctggg tggggaggag 1741 ggtaactttt gggtctgtca taaatagagg gccc (2) INFORMATION FOR SEQ ID NO:2723: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear )xi)SEQUENCE DESCRIPTION: SEQ ID NO:2723 1 atttttttgt agagacaggg tctctctatg ttgcccaagc tggtttcaaa ctcccaggct WO 00/09525 PCT/US99/17712 EPI-109 1006 61 caagcaatcc tcctgccztg gcctcccaaa gtgctggcat tacaqgcgtg agccactgcg 121 cctggcccgt attaatgttt agaacacgaa ttccaggagg caggctaagt ctattcagct 181 tgttcatatg cttgggccaa cccaagaaac aagtgggtga caaatggcac cttttggata 241 gtggtattga ctttgaaagt ttgggtcagg aagctgggga ggaagggtgg gcaggctgtg 301 ggcagtcctg ggcggaagac caggcagggc tatgtgctca ctgagcctcc gccctcttcc 361 tttgaatctc tgatagactt ctgcctccta cttctccttt tctgcccttc tttgctttgg 421 tggcttcctt gtggttcctc agtggtgcct gcaacccctg gttcacctcc ttccaggttc 481 tggctccttc cagccatggc tctcagagtc cttctgttaa caggtgcatg ggg 1 gaattccgtg gttcctcagt ggtgcctgca acccctggtt cacctccttc caggttctgg 61 ctccttccag ccatggcrct cagagtcctt ctgttaacag ccttgacctt atgtcatggg 121 ttcaacttgg acactgaaaa cgcaatgacc ttccaagaga acgcaagggg cttcgggcag 181 agcgtggtcc agcttcaggg atccagggtg gtggttggag ccccccagga gatagtggct 241 gccaaccaaa ggggcagcct ctaccagtgc gactacagca caggctcatg cgagcccatc 301 cgcctgcagg tccccgtgga ggccgtgaac atgtccctgg gcctgtccct ggcagccacc 361 accagccccc ctcagctgct ggcctgtggt cccaccgtgc accagacttg cagtgagaac 421 acgtatgtga aagggctctg cttcctgttt ggatccaacc tacggcagca gccccagaag 481 ttcccagagg ccctccgagg gtgtcctcaa gaggatagtg acattgcctt cttgattgat 541 ggctctggta gcatcatccc acatgacttt cggcggatga aggagtttgt ctcaactgtg 601 atggagcaat taaaaaagtc caaaaccttg ttctctttga tgcagtactc tgaagaattc 661 cggattcact ttaccttcaa agagttccag aacaacccta acccaagatc actggtgaag 721 ccaataacgc agctgcttgg gcggacacac acggccacgg gcatccgcaa agtggtacga 781 gagctgttta acatcaccaa cggagcccga aagaatgcct ttaagatcct agttgtcatc 841 acggatggag aaaagtttgg cgatcccttg ggatatgagg atgtcatccc tgaggcagac 901 agagagggag tcattcgcta cgtcattggg gtgggagatg ccttccgcag tgagaaatcc 961 cgccaagagc ttaataccat cgcatccaag ccgcctcgtg atcacgtgtt ccaggtgaat 1021 aactttgagg ctctgaagac cattcagaac cagcttcggg agaagatctt tgcgatcgag 1081 ggtactcaga caggaagtag cagctccttt gagcatgaga tgtctcagga aggcttcagc 1141 gctgccatca cctctaatgg ccccttgctg agcactgtgg ggagctatga ctgggctggt 1201 ggagtctttc tatatacatc aaaggagaaa agcaccttca tcaacatgac cagagtggat 1261 tcagacatga atgatgctta cttgggttat gctgccgcca tcatcttacg gaaccgggtg 1321 caaagcctgg ttctgggggc acctcgatat cagcacatcg gcctggtagc gatgttcagg 1381 cagaacactg gcatgtggga gtccaacgct aatgtcaagg gcacccagat cggcgcctac 1441 ttcggggcct ccctctgctc cgtggacgtg gacagcaacg gcagcaccga cctggtcctc 1501 atcggggccc cccattacta cgagcagacc cgagggggcc aggtgtccgt gtgccccttg 1561 cccagggggc agagggctcg gtggcagtgt gatgctgttc tctacgggga gcagggccaa 1621 ccctggggcc gctttggggc agccctaaca gtgctggggg acgtaaatgg ggacaagctg 1681 acggacgtgg ccattggggc cccaggagag gaggacaacc ggggtgctgt ttacctgttt 1741 cacggaacct caggatctgg catcagcccc tcccatagcc agcggatagc aggctccaag 1801 ctctctccca ggctccagta ttttggtcag tcactgagtg ggggccagga cctcacaatg 1861 gatggactgg tagacctgac tgtaggagcc caggggcacg tgctgctgct caggtcccag 1921 ccagtactga gagtcaaggc aatcatggag ttcaatccca gggaagtggc aaggaatgta 1981 tttgagtgta atgatcaggt ggtgaaaggc aaggaagccg gagaggtcag agtctgcctc 2041 catgtccaga agagcacacg ggatcggcta agagaaggac agatccagag tgttgtgact 2101 tatgacctgg ctctggactc cggccgccca cattcccgcg ccgtcttcaa tgagacaaag 2161 aacaqcacac gcagacagac acaggtcttg gggctgaccc agacttgtga gaccctgaaa 2221 ctacagttgc cgaattgcat cgaggaccca gtgagcccca ttgtgctgcg cctgaacttc 2281 tctctggtgg gaacqccatt gtctgctttc gggaacctcc ggccagtgct ggcggaggat 2341 gctcagagac tcttcacagc cttgtttccc tttgagaaga attgtggcaa tgacaacatc 2401 tgccaggatg acctcagcat caccttcagt ttcatgagcc tggactgcct cgtggtgggt 2461 gggccccggg agttcaacgt gacagtgact gtgagaaatg atggtgagga ctcctacagg 2521 acacaggtca ccttcttctt cccgcttgac ctgtcctacc ggaaggtgtc cacactccag 2581 aaccagcgct cacagcgatc ctggcgcctg gcctgtgagt ctgcctcctc caccgaagtg 2641 tctggggcct tgaagagcac cagctgcagc ataaaccacc ccatcttccc ggaaaactca 2701 gaggtcacct ttaatatcac gtttgatgta gactctaagg cttcccttgg aaacaaactg 2761 ctcctcaagg ccaatgtgac cagtgagaac aacatgccca gaaccaacaa aaccgaattc 2821 caactggagc tgccggtgaa atatgctgtc tacatggtgg tcaccagcca tggggtctcc 2881 actaaatatc tcaacttcac ggcctcagag aataccagtc gggtcatgca gcatcaatat 2941 caggtcagca acctggggca gaggagcctc cccatcagcc tggtgttctt ggtgcccgtc 3001 cggctgaacc agactgtcat atgggaccgc ccccaggtca ccttctccga gaacctctcg 3061 agtacgtgcc acaccaagga gcgcttgccc tctcactccg actttctggc tgagcttcgg 3121 aaggcccccg tggtgaactg ctccatcgct gtctgccaga gaatccagtg tgacatcccg 3181 ttctttggca tccaggaaga attcaatgct accctcaaag gcaacctctc gtttgactgg 3241 tacatcaaga cctcgcataa ccacctcctg atcgtgagca cagctgagat cttgtttaac 3301 gattccgtgt tcaccctqct gccgggacag ggggcgtttg tgaggtccca gacggagacc 3361 aaagtggagc cgttcgaggt ccccaacccc ctgccgctca tcgtgggcag ctctgtcggg 3421 ggactgctgc tcctggccct catcaccgcc gcgctgtaca agctcggctt cttcaagcgg 3481 caatacaagg acatgatgag tgaagggggt cccccggggg ccgaacccca gtagcggctc 3541 cttcccgaca gagctgcctc tcggtggcca gcaggactct gcccagacca cacgtagccc WO 00/09525 PCT/US99/17712 EPI-109 1007 3601 ccaggctgct ggacacarcg gacagcgaag tatccccgac aggacgggct tgggcttcca 3661 tttgtgtgtg tgcaagtgtg tatgtgcgtg tgtgcgagtg tgtgcaagtg tctgtgtgca 3721 agtgtgtgca cgtgtgcgtg tgcgtgcatg tgcactcgca cgcccatgtg tgagtgtgtg 3781 caagtatgtg agtgtgtcca gtgtgtgtgc gtgtgtccat gtgtgtgcag tgtgtgcatg 3841 tgtgcgagtg tgtgcatgtg tgtgctcagg ggctgtggct cacgtgtgtg actcagagtg 3901 tctctggcgt gtgggtaggt gacggcagcg tagcctctcc ggcagaaggg aactgcctgg 3961 gctcccttgt gcgtgggtaa gccgctgctg ggttttcctc cgggagaggg gacggtcaat 4021 cctgtgggtg aagagagagg gaaacacagc agcatctctc cactgaaaga agtgggactt 4081 cccgtcgcct gcgagcctgc ggcctgctgg agcctgcgca gcttggatgg atactccatg 4141 agaaaagccg tgggtggaac caggagcctc ctccacacca gcgctgatgc ccaataaaga 4201 tgcccactga ggaatcatga agcttccttt ctggattcat ttattatttc aatgtgactt 4261 taattttttg gatggataag cctgtctatg gtacaaaaat cacaaggcat tcaagtgtac 4321 agtgaaaagt ctccctttcc agatattcaa gtcacctcct taaaggtagt caagattgtg 4381 ttttgaggtt tccttcagac agattccagg cgatgtgcaa gtgtatgcac gtgtgcacac 4441 accacacaca tacacacaca caagcttttt tacacaaatg gtagcatact ttatattggt 4501 ctgtatcttg ctttttttca ccaatatttc tcagacatcg gttcatatta agacataaat 4561 tactttttca ttcttttata ccgctgcata gtattccatt gtgtgagtgt accataatgt 4621 atttaaccag tcttcttttq atatactatt ttcatctctt gttattgcat ctgctgagtt 4681 aataaatcaa atatatgtca aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 1 ggttcaagtg attctgctgc ctcagcctcc caggcgggat tacaggtgcc tgccaccacg 61 cctggctaat ttttttgtct ttttagtaaa gatgaggttt caccatgttg ggcaggctgg 121 tttcaattgc tgacctcaag tgagccaccc cgcctcagcc tccaaaatgc taggattaca 181 ggcatgagcc accgcaccca gccaagtttg tacatatatt tttgactaca cttcttaact 241 attcttagga taaattacta gaagtgaaaa ttcttgggtg aagagcttga ggcctttaca 301 cacacacaca cacacacaca cacacacaca caaataggct ggatcgagtg gctcacacct 361 gtaatctcag cagtttggga ggctgaggaa ggaggatcac ttgagtccag gaggttgaga 421 atagcctgaa caacatagca agatcttgtc tctacaaaaa agtttaaaaa aaattagctg 481 gccatggcag catgtgcctg tagtaccagc tactcggaag gctgaggtag gaggatcgct 541 tgagcccagg aggtgattga agctgcagtg agctgtgatt acaccactgc actccagcct 601 gggcaacaga gctagactct gtctctaaaa aaaggcacaa aataatattt aaaaagcacc 661 aggtatgcct gtacttgagt tgtctttgtt gatggctaca aatgagacag ctctggctga 721 agggcggctt ccatttccat gggctggagg aggacatttt gcaaagtgtg ttttcaggaa 781 gacacagagt tttacctcct acacttgttt gatctgtatt aatgtttgct tatttattta 841 tttaattttt tttttgagac agagtctcac tctgtcacct gggctggagt gcagtggcat 901 tattgaggct cattgcagtc tcagactcct gagctcaaac aatcctcctg cctcagcctc 961 tggagtagct aggactacag gcatgtgcca ccatgcctgg ctaatttttt aaatgtattt 1021 ttttgtagag tcggggtctc cctatgttgc ccaggctgga gtgcagtggt gtgatcctag 1081 ctcactgcag cctggacctc gggctcaaga aattctcaca cctcagcctg tccagtagca 1141 ggggctacag gcgcgcacca ccatcccagc taattaaaaa tatttttttg tagagacagg 1201 gtctctctat gttgcccagg ctggtttcaa actcccaggc tcaagcaatc ctcctgcctt 1261 gcctcccaaa tgacatcgga ttacaggcgt gagccactga gcctggcccg tattaatgtt 1321 tagaacacga attccaggag gcaggctaag tctattcagc ttgttcatat gcttgggcca 1381 acccaagaaa caagtgggtg acaaatggca ccttttggat agtggtattg actttgaaag 1441 tttgggtcag gagctgggga ggaagggtgg gcaggctgtg ggcagtcctg ggcggaagac 1501 caggcagggc tatgtgctca ctgagcctcc gccctcttcc tttgaatctc tgatagactt 1561 ctgcctccta cttctccttt tctgcccttc tttgctttgg tggcttcctt gtggttcctc 1621 agtggtgcct gcaaccctgg ttcactcttc caggttctgg ctccttccag ccatggctct 1681 cagagtcctt ctgttaacag gtgcatgggg gtggggtggg ggactctggg tggggaggag 1741 ggtaactttt gggtctgtca taaatagagg gccc (2) INFORMATION FOR SEQ ID NO:2724: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRA14DEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2724 1 ctgcagctcc ggaacggggg ggggctgctc tccaccgccc ctgtgcggcc gcccgggaaa 61 gtgcaggcgg gccgggcgcg gtggctcacg cctgtgatct cagcactttg ggaggccgag 121 gtgggcggat cacctgaggt cgggagttcg aggccagcct gcccaacatg gagaaaccct 181 gtctctacta aagatacaaa attagccagg cgtggtgacg catgcctgta atcccagcta 241 ctggagtggc tgaggcagga gaatcgcttg agcccgggag acagaggttg cggtgagctg 301 agatcgcacc attgcactcc agcctgggca acaagagcga aactcagaaa aaaaagaaaa 361 gaaagtgcag gggacccgcc gtcggggtgg gggcggcgct gcccagcctc tgtcccactt 421 ccatgcactt gacctcgacc ctccggcctc cgtctgcgat cttcccgtgc ctgaatatga 481 ggcttggaac agacccagac cttcctgcct gcccgtcctg agtggccccg ggaccccgcc 541 ccatctttgg cccccagccc ctgcctctct gccgcctcca gggtcggggg tcaggccagg 601 aaagcccctt gggaagcccc cggggagcag ctggagcggg gtcgccgggc ggcgggaagg 661 agtgggcgcc tctatttaag cggcttcccc gcggcctcgg gacagagggg actgagcatg WO 00/09525 PCT/US99/17712 EPI-109 1008 721 gatttcggac tggccctcct gctggcgggg cttctggggc tcctcctcgg tgagaaggg (2) INFORMATION FOR SEQ ID NO:2725: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2725 1 atggatttcg gactggccct cctgctggcg gggcttctgg ggctcctcct cggccagtcc 61 ctccaggtga agcccctgca ggtggagccc ccggagccgg tggtggccgt ggccttgggc 121 gcctcgcgcc agctcacctg ccgcctggcc tgcgcggacc gcggggcctc ggtgcagtgg 181 cggggcctgg acaccagcct gggcgcggtg cagtcggaca cgggccgcag cgtcctcacc 241 gtgcgcaacg cctcgctgtc ggcggccggg acccgcgtgt gcgtgggctc ctgcgggggc 301 cgcaccttcc agcacaccgt gcagctcctt gtgtacgcct tcccggacca gctgaccgtc 361 tccccagcag ccctggtgcc tggtgacccg gaggtggcct gtacggccca caaagtcacg 421 cccgtggacc ccaacgcgct ctccttctcc ctgctcgtcg ggggccagga actggagggg 481 gcgcaagccc tgggcccgga ggtgcaggag gaggaggagg agccccaggg ggacgaggac 541 gtgctgttca gggtgacaga gcgctggcgg ctgccgcccc tggggacccc tgtcccgccc 601 gccctctact gccaggccac gatgaggctg cctggcttgg agctcagcca ccgccaggcc 661 atccccgtcc tgcacagccc gacctccccg gagcctcccg acaccacctc cccggagcct 721 cccaacacca cctccccgga gtctcccgac accacctccc cggagtctcc cgacaccacc 781 tcccaggagc ctcccgacac cacctcccag gagcctcccg acaccacctc ccaggagcct 841 cccgacacca cctccccgga gcctcccgac aagacctccc cggagcccgc cccccagcag 901 ggctccacac acacccccag gagcccaggc tccaccagga ctcgccgccc tgagatctcc 961 caggctgggc ccacgcaggg agaagtgatc ccaacaggct cgtccaaacc tgcgggtgac 1021 cagctgcccg cggctctgtg gaccagcagt gcggtgctgg gactgctgct cctggccttg 1081 cccacgtatc acctctggaa acgctgccgg cacctggctg aggacgacac ccacccacca 1141 gcttctctga ggcttctgcc ccaggtgtcg gcctgggctg ggttaagggg gaccggccag 1201 gtcgggatca gcccctcctg agtggccagc ctttccccct gtgaaagcaa aatagcttgg 1261 accccttcaa gttgagaact ggtcagggca aacctgcctc ccattctact caaagtcatc 1321 cctctgctca cagagatgga tgcatgttct gattgcctct ttggagaagc tcatcagaaa 1381 ctcaaaagaa ggccactgtt tgtctcacct acccatgacc tgaagcccct ccctgagtgg 1441 tccccacctt tctggacgga accacgtact ttttacatac attgattcat gtctcacgtc 1501 tccctaaaaa tgcgtaagac caagctgtgc cctgaccacc ctgggcccct gtcgtcagga 1561 cctcctgagg ctttggcaaa taaacctcct aaaatgat (2) INFORMATION FOR SEQ ID NO:2726: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2726 1 tccatcacag ccttcccgga ccagctgacc gtctccccag cagccctggt gcctggtgac 61 ccggaggtgg cctgtacggc ccacaaagtc acgcccgtgg accccaacgc gctctccttc 121 tccctgctcg tcgggggcca ggaactggag ggggcgcaag ccctgggccc ggaggtgcag 181 gaggaggagg aggagcccca gggggacgag gacgtgctgt tcagggtgac agagcgctgg 241 cggctgccgc ccctggggac ccctgtcccg cccgccctct actgccaggc cacgatgagg 301 ctgcctggct tggagctcag ccaccgccag gccatccccg gtgagtccgc (2) INFORMATION FOR SEQ ID NO:2727: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2727 1 gtcgccgcag gccagtccct ccaggtgaag cccctgcagg tggagccccc ggagccggtg 61 gtggccgtgg ccttgggcgc ctcgcgccag ctcacctgcc gcctggcctg cgcggaccgc 121 ggggcctcgg tgcagtggcg gggcctggac accagcctgg gcgcggtgca gtcggacacg 181 ggccgcagcg tcctcaccgt gcgcaacgcc tcgctgtcgg cggccgggac ccgcgtgtgc 241 gtgggctcct gcgggggccg caccttccag cacaccgtgc agctccttgt gtacggtgag 301 gcgtc (2) INFORMATION FOR SEQ ID NO:2728: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single WO 00/09525 PCT/US99/17712 EPI-109 1009 (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2728 1 ctgtttccag tcctgcacag cccgacctcc ccggagcctc ccgacaccac ctccccggag 61 cctcccaaca ccacctcccc ggagtctccc gacaccacct ccccggagtc tcccgacacc 121 acctcccagg agcctcccga caccacctcc caggagcctc ccgacaccac ctcccaggag 181 cctcccgaca ccacctcccc ggagcctccc gacaagacct ccccggagcc cgccccccag 241 cagggctcca cacacacccc caggagccca ggctccacca ggactcgccg ccctgagatc 301 tcccaggctg ggcccacgca gggagaagtg atcccaacag gctgtgagtt ctg (2) INFORMATION FOR SEQ ID NO:2729: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2729 1 ctctccccag cgtccaaacc tgcgggtgac cagctgcccg cggctctgtg gaccagcagt 61 gcggtgctgg gactgctgct cctggccttg cccacgtatc acctctggaa acgctgccgg 121 cacctggctg aggacgacac ccacccacca gcttctctga ggcttctgcc ccaggtgtcg 181 gcctgggctg ggttaagggg gaccggccag gtcgggatca gcccctcctg agtggccagc 241 ctttccccct gtgaaagcaa aatagcttgg accccttcaa gttgagaact ggtcagggca 301 aacctgcctc ccattctact caaagtcatc cctctgttca cagagatgga tgcatgttct 361 gattgcctct ttggagaagc tcatcagaaa ctcaaaagaa ggccactgtt tgtctcacct 421 acccatgacc tgaagcccct ccctgagtgg tccccacctt tctggacgga accacgtact 481 ttttacatac attgattcat gtctcacgtc tccctaaaaa tgcgtaagac caagctgtgc 541 cctgaccacc ctgggcccct gtcgtcagga cctcctgagg ctttggcaaa taaacctcct 601 aaaatgat (2) INFORMATION FOR SEQ ID NO:2730: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2730 1 gggactgagc atggatttcg gactggccct cctgctggcg gggcttctgg ggctcctcct 61 cggccagtcc ctccaggtga agcccctgca ggtggagccc ccggagccgg tggtggccgt 121 ggccttgggc gcctcgcgcc agctcacctg ccgcctggcc tgcgcggacc gcggggcctc 181 ggtgcagtgg cggggcctgg acaccagcct gggcgcggtg cagtcggaca cgggccgcag 241 cgtcctcacc gtgcgcaacg cctcgctgtc ggcggccggg acccgcgtgt gcgtgggctc 301 ctgcgggggc cgcaccttcc agcacaccgt gcagctcctt gtgtacgcct tcccggacca 361 gctgaccgtc tccccagcag ccctggtgcc tggtgacccg gaggtggcct gtacggccca 421 caaagtcacg cccgtggacc ccaacgcgct ctccttctcc ctgctcgtcg ggggccagga 481 actggagggg gcgcaagccc tgggcccgga ggtgcaggag gaggaggagg agccccaggg 541 ggacgaggac gtgctgttca gggtgacaga gcgctggcgg ctgccgcccc tggggacccc 601 tgtcccgccc gccctctact gccaggccac gatgaggctg cctggcttgg agctcagcca 661 ccgccaggcc atccccgtcc tgcacagccc gacctccccg gagcctcccg acaccacctc 721 cccggagtct cccgacacca cctccccgga gtctcccgac accacctccc cggagcctcc 781 cgacaccacc tccccggagc ctcccgacaa gacctccccg gagcccgccc cccagcaggg 841 ctccacacac acccccagga gcccaggctc caccaggact cgccgccctg agatctccca 901 ggctgggccc acgcagggag aagtgatccc aacaggctcg tccaaacctg cgggtgacca 961 gctgcccgcg gctctgtgga ccagcagtgc ggtgctggga ctgctgctcc tggccttgcc 1021 cacgtatcac ctctggaaac gctgccggca cctggctgag gacgacaccc acccaccagc 1081 ttctctgagg cttctgcccc aggtgtcggc ctgggctggg ttaaggggga ccggccaggt 1141 cgggatcagc ccctcctgag tggccagcct ttccccctgt gaaagcaaaa tagcttggac 1201 cccttcaagt tgagaactgg tcagggcaaa cctgcctccc attctactca aagtcatccc 1261 tctgttcaca gagatggatg catgttctga ttgcctcttt ggagaagctc atcagaaact 1321 caaaagaagg ccactgtttg tctcacctac ccatgacctg aagcccctcc ctgagtggtc 1381 cccacctttc tggacggaac cacgtacttt ttacatacat tgattcatgt ctcacgtctc 1441 cctaaaaatg cgtaagacca agctgtgccc tgaccaccct gggcccctgt cgtcaggacc 1501 tcctgaggct ttggcaaaa aacctcctaa aatgataaaa aaaaaa (2) INFORMATION FOR SEQ ID NO:2731: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2731 1 ctgcagctcc ggaacggggg ggggctgctc tccaccgccc ctgtgcggcc gcccgggaaa WO 00/09525 PCT/US99/17712 EPI-109 1010 61 gtgcaggcgg gccgggcgcg gtggctcacg cctgtgatct cagcactttg ggaggccgag 121 gtgggcggat cacctgaggt cgggagttcg aggccagcct gcccaacatg gagaaaccct 181 gtctctacta aagatacaaa attagccagg cgtggtgacg catgcctgta atcccagcta 241 ctggagtggc tgaggcagga gaatcgcttg agcccgggag acagaggttg cggtgagctg 301 agatcgcacc attgcactcc agcctgggca acaagagcga aactcagaaa aaaaagaaaa 361 gaaagtgcag gggacccgcc gtcggggtgg gggcggcgct gcccagcctc tgtcccactt 421 ccatgcactt gacctcgacc ctccggcctc cgtctgcgat cttcccgtgc ctgaatatga 481 ggcttggaac agacccagac cttcctgcct gcccgtcctg agtggccccg ggaccccgcc 541 ccatctttgg cccccagccc ctgcctctct gccgcctcca gggtcggggg tcaggccagg 601 aaagcccctt gggaagcccc cggggagcag ctggagcggg gtcgccgggc ggcgggaagg 661 agtgggcgcc tctatttaag cggcttcccc gcggcctcgg gacagagggg actgagcatg 721 gatttcggac tggccctcct gctggcgggg cttctggggc tcctcctcgg tgagaaggg 1 atggatttcg gactggccct cctgctggcg gggcttctgg ggctcctcct cggccagtcc 61 ctccaggtga agcccctgca ggtggagccc ccggagccgg tggtggccgt ggccttgggc 121 gcctcgcgcc agctcacctg ccgcctggcc tgcgcggacc gcggggcctc ggtgcagtgg 181 cggggcctgg acaccagcct gggcgcggtg cagtcggaca cgggccgcag cgtcctcacc 241 gtgcgcaacg cctcgctgtc ggcggccggg acccgcgtgt gcgtgggctc ctgcgggggc 301 cgcaccttcc agcacaccgt gcagctcctt gtgtacgcct tcccggacca gctgaccgtc 361 tccccagcag ccctggtgcc tggtgacccg gaggtggcct gtacggccca caaagtcacg 421 cccgtggacc ccaacgcgct ctccttctcc ctgctcgtcg ggggccagga actggagggg 481 gcgcaagccc tgggcccgga ggtgcaggag gaggaggagg agccccaggg ggacgaggac 541 gtgctgttca gggtgacaga gcgctggcgg ctgccgcccc tggggacccc tgtcccgccc 601 gccctctact gccaggccac gatgaggctg cctggcttgg agctcagcca ccgccaggcc 661 atccccgtcc tgcacagccc gacctccccg gagcctcccg acaccacctc cccggagcct 721 cccaacacca cctccccgga gtctcccgac accacctccc cggagtctcc cgacaccacc 781 tcccaggagc ctcccgacac cacctcccag gagcctcccg acaccacctc ccaggagcct 841 cccgacacca cctccccgga gcctcccgac aagacctccc cggagcccgc cccccagcag 901 ggctccacac acacccccag gagcccaggc tccaccagga ctcgccgccc tgagatctcc 961 caggctgggc ccacgcaggg agaagtgatc ccaacaggct cgtccaaacc tgcgggtgac 1021 cagctgcccg cggctctgtg gaccagcagt gcggtgctgg gactgctgct cctggccttg 1081 cccacgtatc acctctggaa acgctgccgg cacctggctg aggacgacac ccacccacca 1141 gcttctctga ggcttctgcc ccaggtgtcg gcctgggctg ggttaagggg gaccggccag 1201 gtcgggatca gcccctcctg agtggccagc ctttccccct gtgaaagcaa aatagcttgg 1261 accccttcaa gttgagaact ggtcagggca aacctgcctc ccattctact caaagtcatc 1321 cctctgctca cagagatgga tgcatgttct gattgcctct ttggagaagc tcatcagaaa 1381 ctcaaaagaa ggccactgtt tgtctcacct acccatgacc tgaagcccct ccctgagtgg 1441 tccccacctt tctggacgga accacgtact ttttacatac attgattcat gtctcacgtc 1501 tccctaaaaa tgcgtaagac caagctgtgc cctgaccacc ctgggcccct gtcgtcagga 1561 cctcctgagg ctttggcaaa taaacctcct aaaatgat 1 tccatcacag ccttcccgga ccagctgacc gtctccccag cagccctggt gcctggtgac 61 ccggaggtgg cctgtacggc ccacaaagtc acgcccgtgg accccaacgc gctctccttc 121 tccctgctcg tcgggggcca ggaactggag ggggcgcaag ccctgggccc ggaggtgcag 181 gaggaggagg aggagcccca gggggacgag gacgtgctgt tcagggtgac agagcgctgg 241 cggctgccgc ccctggggac ccctgtcccg cccgccctct actgccaggc cacgatgagg 301 ctgcctggct tggagctcag ccaccgccag gccatccccg gtgagtccgc 1 gtcgccgcag gccagtccct ccaggtgaag cccctgcagg tggagccccc ggagccggtg 61 gtggccgtgg ccttgggcgc ctcgcgccag ctcacctgcc gcctggcctg cgcggaccgc 121 ggggcctcgg tgcagtggcg gggcctggac accagcctgg gcgcggtgca gtcggacacg 181 ggccgcagcg tcctcaccgt gcgcaacgcc tcgctgtcgg cggccgggac ccgcgtgtgc 241 gtgggctcct gcgggggccg caccttccag cacaccgtgc agctccttgt gtacggtgag 301 gcgtc 1 ctgtttccag tcctgcacag cccgacctcc ccggagcctc ccgacaccac ctccccggag 61 cctcccaaca ccacctcccc ggagtctccc gacaccacct ccccggagtc tccgacacc 121 acctcccagg agcctcccga caccacctcc caggagcctc ccgacaccac ctcccaggag 181 cctcccgaca ccacctcccc ggagcctccc gacaagacct ccccggagcc cgccccccag 241 cagggctcca cacacacccc caggagccca ggctccacca ggactcgccg ccctgagatc 301 tcccaggctg ggcccacgca gggagaagtg atcccaacag gctgtgagtt ctg 1 ctctccccag cgtccaaacc tgcgggtgac cagctgcccg cggctctgtg gaccagcagt 61 gcggtgctgg gactgctgct cctggccttg cccacgtatc acctctggaa acgctgccgg 121'cacctggctg aggacgacac ccacccacca gcttctctga ggcttctgcc ccaggtgtcg 181 gcctgggctg ggttaagggg gaccggccag gtcgggatca gcccctcctg agtggccagc 241 ctttccccct gtgaaagcaa aatagcttgg accccttcaa gttgagaact ggtcagggca 301 aacctgcctc ccattctact caaagtcatc cctctgttca cagagatgga tgcatgttct 361 gattgcctct ttggagaagc tcatcagaaa ctcaaaagaa ggccactgtt tgtctcacct 421 acccatgacc tgaagcccct ccctgagtgg tccccacctt tctggacgga accacgtact 481 ttttacatac attgattcat gtctcacgtc tccctaaaaa tgcgtaagac caagctgtgc 541 cctgaccacc ctgggcccct gtcgtcagga cctcctgagg ctttggcaaa taaacctcct 601 aaaatgat WO 00/09525 PCTIUS99/17712 EPI-109 1011 1 gggactgagc atggatttcg gactggccct cctgctggcg gggcttctgg ggctcctcct 61 cggccagtcc ctccaggtga agcccctgca ggtggagccc ccggagccgg tggtggccgt 121 ggccttgggc gcctcgcgcc agctcacctg ccgcctggcc tgcgcggacc gcggggcctc 181 ggtgcagtgg cggggcctgg acaccagcct gggcgcggtg cagtcggaca cgggccgcag 241 cgtcctcacc gtgcgcaacg cctcgctgtc ggcggccggg acccgcgtgt gcgtgggctc 301 ctgcgggggc cgcaccttcc agcacaccgt gcagctcctt gtgtacgcct tcccggacca 361 gctgaccgtc tccccagcag ccctggtgcc tggtgacccg gaggtggcct gtacggccca 421 caaagtcacg cccgtggacc ccaacgcgct ctccttctcc ctgctcgtcg ggggccagga 481 actggagggg gcgcaagccc tgggcccgga ggtgcaggag gaggaggagg agccccaggg 541 ggacgaggac gtgctgttca gggtgacaga gcgctggcgg ctgccgcccc tggggacccc 601 tgtcccgccc gccctctact gccaggccac gatgaggctg cctggcttgg agctcagcca 661 ccgccaggcc atccccgtcc tgcacagccc gacctccccg gagcctcccg acaccacctc 721 cccggagtct cccgacacca cctccccgga gtctcccgac accacctccc cggagcctcc 781 cgacaccacc tccccggagc ctcccgacaa gacctccccg gagcccgccc cccagcaggg 841 ctccacacac acccccagga gcccaggctc caccaggact cgccgccctg agatctccca 901 ggctgggccc acgcagggag aagtgatccc aacaggctcg tccaaacctg cgggtgacca 961 gctgcccgcg gctctgtgga ccagcagtgc ggtgctggga ctgctgctcc tggccttgcc 1021 cacgtatcac ctctggaaac gctgccggca cctggctgag gacgacaccc acccaccagc 1081 ttctctgagg cttctgcccc aggtgtcggc ctgggctggg ttaaggggga ccggccaggt 1141 cgggatcagc ccctcctgag tggccagcct ttccccctgt gaaagcaaaa tagcttggac 1201 cccttcaagt tgagaactgg tcagggcaaa cctgcctccc attctactca aagtcatccc 1261 tctgttcaca gagatggatg catgttctga ttgcctcttt ggagaagctc atcagaaact 1321 caaaagaagg ccactgtttg tctcacctac ccatgacctg aagcccctcc ctgagtggtc 1381 cccacctttc tggacggaac cacgtacttt ttacatacat tgattcatgt ctcacgtctc 1441 cctaaaaatg cgtaagacca agctgtgccc tgaccaccct gggcccctgt cgtcaggacc 1501 tcctgaggct ttggcaaata aacctcctaa aatgataaaa aaaaaa (2) INFORMATION FOR SEQ ID NO:2732: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: _base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQOENCE DESCRIPTION: SEQ ID NO:2732 1 ggaattccgg gcccggtctt tcctcccgcc gccgccggcc tggtcccggg gactggcctc 61 cacgtccgac tcgtccgagc tgaagcccag cagcactttg ctgccagccg cgggggcggc 121 ggaggcgccc ccgggccctc ccaggaggct ctctgggcca gaggccgaga ttcggcacag 181 gcccccagga gtccgtaagt aggagaggtc gcccgagacc ggccggaccc ccatccccgc 241 ggccgccgcc gccgctggtc ccgcggctgc gaccgtggcg gctgccgctg gaaaatgtct 301 caggagaggc ccacgttcta ccggcaggag ctgaacaaga caatctggga ggtgcccgag 361 cgttaccaga acctgtctcc agtgggctct ggcgcctatg gctctgtgtg tgctgctttt 421 gacacaaaaa cggggttacg tgtggcagtg aagaagctct ccagaccatt tcagtccatc 481 attcatgcga aaagaaccta cagagaactg cggttactta aacatatgaa acatgaaaat 541 gtgattggtc tgttggacgt ttttacacct gcaaggtctc tggaggaatt caatgatgtg 601 tatctggtga cccatctcat gggggcagat ctgaacaaca ttgtgaaatg tcagaagctt 661 acagatgacc atgttcagtt ccttatctac caaattctcc gaggtctaaa gtatatacat 721 tcagctgaca taattcacag ggacctaaaa cctagtaatc tagctgtgaa tgaagactgt 781 gagctgaaga ttctggattt tggactggct cggcacacag atgatgaaat gacaggctac 841 gtggccacta ggtggtacag ggctcctgag atcatgctga actggatgca ttacaaccag 901 acagttgata tttggtcagt gggatgcata atggccgagc tgttgactgg aagaacattg 961 tttcctggta cagaccatat tgatcagttg aagctcattt taagactcgt tggaacccca 1021 ggggctgagc ttttgaagaa aatctcctca gagtctgcaa gaaactatat tcagtctttg 1081 actcagatgc cgaagatgaa ctttgcgaat gtatttattg gtgccaatcc cctggctgtc 1141 gacttgctgg agaagatgct tgtattggac tcagataaga gaattacagc ggcccaagcc 1201 cttgcacatg cctactttgc tcagtaccac gatcctgatg atgaaccagt ggccgatcct 1261 tatgatcagt cctttgaaag cagggacctc cttatagatg agtggaaaag cctgacctat 1321 gatgaagtca tcagctttgt gccaccaccc cttgaccaag aagagatgga gtcctgagca 1381 cctggtttct gttctgttga tcccacttca ctgtgagggg aaggcctttt cacgggaact 1441 ctccaaatat tattcaagtg cctcttgttg cagagatttc ctccatggtg gaagggggtg 1501 tgcgtgcgtg tgcgtgcgtg ttagtgtgtg tgcatgtgt (2) INFORMATION FOR SEQ ID' NO:2733: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2733 1 aattaaccct cactaaaggg agtcgactcg atccccccgc ctcagcccct tttttctttt WO 00/09525 PCT/US99/17712 EPI-109 1012 61 ttttttcatt ttcagttcag gagagtttta gcttaattat aggctacaga accagctttg 121 ggcttcatct atcctttcta atatttactg tttcctattt ctctaatcct agctctttat 181 ttcttccctt tactttcact gggcttattt tgctatagtg gaatgcagag ggatgagtat 241 tccaggaagg cacaaaaact gtgccaagtc ttggagctag ggatgagtgg gaaagggaca 301 tgttcaacca ttttaggcca ttccctcccc acctcccagc tcccagatat gtgcccctcg 361 caggaggagc ccaggaatgg gccaaacacc tcacttcttt gctctgaggg ccaccccagc 421 cctcccatca acagctctag aaacccaatg gtccttcctg gaaacacggg gcctgcatca 481 atcagaggtg tttgaaccat gtccctctgg gcctgagggg cagaagggga cacaatatgt 541 aatgtaagga gcccctgtca tcagaaatct gacttaatct gttttcagat attagacttc 601 cacataaaag ttgacttgga aaaagacttc tgctgctaaa caaaagttga aactgccttg 661 gtgataaaat ataagcagac cagctttctc ttctagcttt ccctctcatt tcccataaga 721 ttttggtcaa gttatttaat ctctctgcat ccgtttcctc ttctatgaaa tgggcatgat 781 aataatggta tatacctcct caaggggggt ataacgtgaa cagagtcctt agcacagcac 841 tctgtctcta cgggagtgaa ttttcattgt ttttctcttt cctgttggag aaagtaagaa 901 gaaaacagcg cctttatggc ttcccatggt gaatggctgg ggcgcgtctg tgtccctgtc 961 tcctctctgg ctccttgtgg cctgaacagc cagaaggaag ccatgccatg ctgtttcagc 1021 cctcagcttc cctcttgcat ttcctagaaa agtctttggt gcccagctcc agctcagcag 1081 attcaggatc ccccttcatc atgacttggt caacgccctg ctcaggccaa ggtcctctga 1141 gagttccaag cttctccact ccctataaaa ggccggcgga acagccagag gagcagagag 1201 gcaaagaaac attgtgaaat ctccaactct taaccttcaa catgaaagtc tctgcagtgc 1261 ttctgtgcct gctgctcatg acagcagctt tcaaccccca gggacttgct cagccaggta 1321 agtcacctcc cttcgactct ccctctcttt ccctctgttt ctctattcaa ggaagaccta 1381 agcccgagtg ctcctccact ttttttttag attgagtctc attatgttgc ccaggctgaa 1441 gtgcaggggt gcgatcttgg ctcattgcaa ccttcacctc ccaggttcaa gcgattctct 1501 tgcctcagcc ttctgagtag ctgtgattac aggcaccgcc atcacgtgca gctaattttt 1561 gtatttttag tagagaaggg gtttcactat gttggccagg ctggtctcaa actcttgacc 1621 tcaagtgatc ctcccgtctc ggcctcccaa agtgctggga ttacaggcgt gagcaccagg 1681 cccagccaag tgccccactt ctaagcccac cagaatagta aggctcctca gaggttcact 1741 ttaacatcta attttaaaga tagaaagctg aagcccatgt tggaggcaga agggacccta 1801 gccatccacc tccaggttat tgcagagcaa gaatgaaacc taagcttctg actccagatt 1861 tagggccttt tctttgacct catctgatcg tcccaaactc tgcagatctg gaccacaccc 1921 agaccttccc actggccttg cccgtggcct cccctagatg gctgtgacat gtctccacca 1981 tgcagctgag cctttgagah cctgaggcac atgtcacagg tcccacctca cctcagggtc 2041 tagggtggga gtgctgggct tgggggtgag taagatctac ttcttcctct ttgctttgca 2101 tcccatacag atgctccctg ctgtattcaa gctgagaaaa gcctaacaca tcctcaaagt 2161 ctttttcttt gtaactattt ctagatgcac tcaacgtccc atctacttgc tgcttcacat 2221 ttagcagtaa gaagatctcc ttgcagaggc tgaagagcta tgtgatcacc accagcaggt 2281 gtccccagaa ggctgtcatg tgggtagaaa aatccctgct cgcctggctc ctccccactc 2341 ccacattccc caatccaaag ttctgcccca ggagacagac gtcagactga cttgagatct 2401 taggatgaga tctagccaga ctgtgtgatg caaaatcctc caattttggc tgcacaacag 2461 gtccaaagag gacctataat ttcccacacc ttgtttcctg gatgggcacc agcccacacc 2521 ctttagcaga tgccaggatc agtttcccag gggcagcaag agcagtggct gcctccagag 2581 accccttctg tccacacac c tcctacttcc tgtcctggag gggtgcccct tcacctgtag 2641 taggtggacc aggcaggttt agaacccagt gtgtcatctc ctaggtaaac cctcaaaggg 2701 ttccatctaa ctgtgccaga tctccttcct ccacagcttc agaaccaaac tgggcaagga 2761 gatctgtgct gacccaaagg agaagtgggt ccagaattat atgaaacacc tgggccggaa 2821 agctcacacc ctgaagactt gaactctgct acccctactg aaatcaagct ggagtacgtg 2881 aaatgacttt tccattctcc tctggcctcc tcttctatgc tttggaatac ttctaccata 2941 attttcaaat aggatgcatt cggttttgtg attcaaaatg tactatgtgt taagtaatat 3001 tggctattat ttgacttgtt gctggtttgg agtttatttg agtattgctg atcttttcta 3061 aagcaaggcc ttgagcaagt aggttgctgt ctctaagccc ccttcccttc cactatgagc 3121 tgctggcagt gggtttgtat tcggttccca ggggttgagc (2) INFORMATION FOR SEQ ID NO:2734: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: _base pairs (B) TYPE: nucleic acid (C) STR?.NDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2734 1 ggcaaagaaa cattgtgaaa tctccaactc ttaaccttca acatgaaagt ctctgcagtg 61 cttctgtgcc tgctgctcat gacagcagct ttcaaccccc agggacttgc tcagccagat 121 gcactcaacg tcccatctac ttgctgcttc acatttagca gtaagaagat ctccttgcag 181 aggctgaaga gctatgtgat caccaccagc aggtgtcccc agaaggctgt catcttcaga 241 accaaactgg gcaaggagat ctgtgctgac ccaaaggaga agtgggtcca gaattatatg 301 aaacacctgg gccggaaagc tcacaccctg aagacttgaa ctctgctacc cctactgaaa 361 tcaagctgga gtacgtgaaa tgacttttcc attctcctct ggcctcctct tctatgcttt 421 ggaatacttc taccataatt ttcaaatagg atgcattcgg ttttgtgatt caaaatgtac 481 tatgtgttaa gtaatattgg ctattatttg acttgttgct ggtttggagt ttatttgagt WO 00/09525 PCT/US99/17712 EPI-109 1013 541 attgctgatc ttttctatag caaggccttg agcaagtagg ttgctgtctc taagccccct 601 tcccttccac tatgagctgc tggcagtggg tttgtattcg gttcccaggg gttgagagca 661 tgcctgtggg agtcatggac atgaagggat gccgcaatgt aggaaggaga gctctttgtg 721 aatgtgaggt gttgctaaat atgttattgt ggaaagatga atgcaatagt aggactgctg 781 acattttgca gaaaatacat tttatttaaa aatctcctaa aaaaaaaaaa aaaaaaaaaa 841 aagaaaaaaa aaaaa (2) INFORMATION FOR SEQ ID NO:2735: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2735 1 acattgtgaa atctccaact cttaaccttc aacatgaaag tctctgcagt gcttctgtgc 61 ctgctgctca tgacagcagc tttcaacccc cagggacttg ctcagccaga tgcactcaac 121 gtcccatcta cttgctgctt cacatttagc agtaagaaga tctccttgca gaggctgaag 181 agctatgtga tcaccaccag caggtgtccc cagaaggctg tcatcttcag aaccaaactg 241 ggcaaggaga tctgtgctga cccaaaggag aagtgggtcc agaattatat gaaacacctg 301 ggccggaaag ctcacaccct gaagacttga actctgctac ccctactgaa atcaagctgg 361 agtacgtgaa atgacttttc cattctcctc tggcctcctc ttctatgctt tggaatactt 421 ctaccataat tttcaaatag gatgcattcg gttttgtgat tcaaaatgta ctatgtgtta 481 agtaatattg gctattattt gacttgttgc tggtttggag tttatttgag tattgctgat 541 cttttctaaa gcaaggcctt gagcaagtag gttgctgtct ctaagccccc ttcccttcca 601 ctatgagctg ctggcagtgg gttgtattcg gttcccaggg gttgagagca tgcctgtggg 661 agtcatggac atgaagggat gctgcaatgt aggaaggaga gctctttgtg aatgtgaggt 721 tgttgctaaa ttattgttta ttgtggaaag atgaatgcaa tagtaggact gctgacattt 781 tgcagaaaat acattttatt taaaatctcc taaaaaaaaa aaaaa (2) INFORMATION FOR SEQ ID NO:2736: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2736 1 aaaaggccgg cggaacagcc agaggagcag agaggcaaag aaacattgtg aaatctccaa 61 ctcttaacct tcaacatgaa agtctctgca gtgcttctgt gcctgctgct catgacagca 121 gctttcaacc cccagggact tgctcagcca gatgcactca acgtcccatc tacttgctgc 181 ttcacattta gcagtaagaa gatctccttg cagaggctga agagctatgt gatcaccacc 241 agcaggtgtc cccagaaggc tgtcatcttc agaaccaaac tgggcaagga gatctgtgct 301 gacccaaagg agaagtgggt ccagaattat atgaaacacc tgggccggaa agctcacacc 361 ctgaagactt gaactctgct acccctactg aaatcaagct ggagtacgtg aaatgacttt 421 tccattctcc tctggcctcc tcttctatgc tttggaatac ttctaccata attttcaaat 481 aggatgcatt cggttttgtg attcaaaatg tactatgtgt taagtaatat tggctattat 541 ttgacttgtt gctggtttgg agtttatttg agtattgctg atcttttcta aagcaaggcc 601 ttgagcaagt aggttgctgt ctctaagccc ccttcccttc cactatgagc tgctggcagt 661 gggtttgtat tcggttccca ggggttgaga gcatgcctgt gggagtcatg gacatgaagg 721 gatgctgcaa tgtaggaagg agagctcttt gtgaatgtga ggtgttgcta aatatgttat 781 tgtggaaaga tgaatgcaat agtaggactg ctgacatttt gcagaaaata cattttattt 841 aaaatctcca aaaaaaaaaa (2) INFORMATION FOR SEQ ID NO:2737: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2737 1 aattaaccct cactaaaggg agtcgactcg atccccccgc ctcagcccct tttttctttt 61 ttttttcatt ttcagttcag gagagtttta gcttaattat aggctacaga accagctttg 121 ggcttcatct atcctttcta atatttactg tttcctattt ctctaatcct agctctttat 181 ttcttccctt tactttcact gggcttattt tgctatagtg gaatgcagag ggatgagtat 241 tccaggaagg cacaaaaact gtgccaagtc ttggagctag ggatgagtgg gaaagggaca 301 tgttcaacca ttttaggcca ttccctcccc acctcccagc tcccagatat gtgcccctcg 361 caggaggagc ccaggaatgg gccaaacacc tcacttcttt gctctgaggg ccaccccagc 421 cctcccatca acagctctag aaacccaatg gtccttcctg gaaacacggg gcctgcatca 481 atcagaggtg tttgaaccat gtccctctgg gcctgagggg cagaagggga cacaatatgt 541 aatgtaagga gcccctgtca tcagaaatct gacttaatct gttttcagat attagacttc WO 00/09525 PCT/US99/17712 EPI-109 1014 601 cacataaaag ttgacttaga aaaagacttc tgctgctaaa caaaagttga aactgccttg 661 gtgataaaat ataagcagac cagctttctc ttctagcttt ccctctcatt tcccataaga 721 ttttggtcaa gttatttaat ctctctgcat ccgtttcctc ttctatgaaa tgggcatgat 781 aataatggta tatacctcct caaggggggt ataacgtgaa cagagtcctt agcacagcac 841 tctgtctcta cgggagtgaa ttttcattgt ttttctcttt cctgttggag aaagtaagaa 901 gaaaacagcg cctttatggc ttcccatggt gaatggctgg ggcgcgtctg tgtccctgtc 961 tcctctctgg ctccttgtgg cctgaacagc cagaaggaag ccatgccatg ctgtttcagc 1021 cctcagcttc cctcttgcat ttcctagaaa agtctttggt gcccagctcc agctcagcag 1081 attcaggatc ccccttcatc atgacttggt caacgccctg ctcaggccaa ggtcctctga 1141 gagttccaag cttctccact ccctataaaa ggccggcgga acagccagag gagcagagag 1201 gcaaagaaac attgtgaaat ctccaactct taaccttcaa catgaaagtc tctgcagtgc 1261 ttctgtgcct gctgctcatg acagcagctt tcaaccccca gggacttgct cagccaggta 1321 agtcacctcc cttcgactct ccctctcttt ccctctgttt ctctattcaa ggaagaccta 1381 agcccgagtg ctcctccact ttttttttag attgagtctc attatgttgc ccaggctgaa 1441 gtgcaggggt gcgatcttgg ctcattgcaa ccttcacctc ccaggttcaa gcgattctct 1501 tgcctcagcc ttctgagtag ctgtgattac aggcaccgcc atcacgtgca gctaattttt 1561 gtatttttag tagagaaggg gtttcactat gttggccagg ctggtctcaa actcttgacc 1621 tcaagtgatc ctcccgtctc ggcctcccaa agtgctggga ttacaggcgt gagcaccagg 1681 cccagccaag tgccccactt ctaagcccac cagaatagta aggctcctca gaggttcact 1741 ttaacatcta attttaaaga tagaaagctg aagcccatgt tggaggcaga agggacccta 1801 gccatccacc tccaggttat tgcagagcaa gaatgaaacc taagcttctg actccagatt 1861 tagggccttt tctttgacct catctgatcg tcccaaactc tgcagatctg gaccacaccc 1921 agaccttccc actggccttg cccgtggcct cccctagatg gctgtgacat gtctccacca 1981 tgcagctgag cctttgagah cctgaggcac atgtcacagg tcccacctca cctcagggtc 2041 tagggtggga gtgctgggct tgggggtgag taagatctac ttcttcctct ttgctttgca 2101 tcccatacag atgctccctg ctgtattcaa gctgagaaaa gcctaacaca tcctcaaagt 2161 ctttttcttt gtaactattt ctagatgcac tcaacgtccc atctacttgc tgcttcacat 2221 ttagcagtaa gaagatcccc ttgcagaggc tgaagagcta tgtgatcacc accagcaggt 2281 gtccccagaa ggctgtcatg tgggtagaaa aatccctgct cgcctggctc ctccccactc 2341 ccacattccc caatccaaag ttctgcccca ggagacagac gtcagactga cttgagatct 2401 taggatgaga tctagccaga ctgtgtgatg caaaatcctc caattttggc tgcacaacag 2461 gtccaaagag gacctataat ttcccacacc ttgtttcctg gatgggcacc agcccacacc 2521 ctttagcaga tgccaggatc agtttcccag gggcagcaag agcagtggct gcctccagag 2581 accccttctg tccacacacc tcctacttcc tgtcctggag gggtgcccct tcacctgtag 2641 taggtggacc aggcaggttt agaacccagt gtgtcatctc ctaggtaaac cctcaaaggg 2701 ttccatctaa ctgtgccaga tctccttcct ccacagcttc agaaccaaac tgggcaagga 2761 gatctgtgct gacccaaagg agaagtgggt ccagaattat atgaaacacc tgggccggaa 2821 agctcacacc ctgaagactt gaactctgct acccctactg aaatcaagct ggagtacgtg 2881 aaatgacttt tccattctcc tctggcctcc tcttctatgc tttggaatac ttctaccata 2941 attttcaaat aggatgcatt cggttttgtg attcaaaatg tactatgtgt taagtaatat 3001 tggctattat ttgacttgtt gctggtttgg agtttatttg agtattgctg atcttttcta 3061 aagcaaggcc ttgagcaagt aggttgctgt ctctaagccc ccttcccttc cactatgagc 3121 tgctggcagt gggtttgtat tcggttccca ggggttgagc 1 ggcaaagaaa cattgtgaaa tctccaactc ttaaccttca acatgaaagt ctctgcagtg 61 cttctgtgcc tgctgctcat gacagcagct ttcaaccccc agggacttgc tcagccagat 121 gcactcaacg tcccatctac ttgctgcttc acatttagca gtaagaagat ctccttgcag 181 aggctgaaga gctatgtgat caccaccagc aggtgtcccc agaaggctgt catcttcaga 241 accaaactgg gcaaggagat ctgtgctgac ccaaaggaga agtgggtcca gaattatatg 301 aaacacctgg gccggaaagc tcacaccctg aagacttgaa ctctgctacc cctactgaaa 361 tcaagctgga gtacgtgaaa tgacttttcc attctcctct ggcctcctct tctatgcttt 421 ggaatacttc taccataatt ttcaaatagg atgcattcgg ttttgtgatt caaaatgtac 481 tatgtgttaa gtaatattgg ctattatttg acttgttgct ggtttggagt ttatttgagt 541 attgctgatc ttttctatag caaggccttg agcaagtagg ttgctgtctc taagccccct 601 tcccttccac tatgagctgc tggcagtggg tttgtattcg gttcccaggg gttgagagca 661 tgcctgtggg agtcatggac atgaagggat gccgcaatgt aggaaggaga gctctttgtg 721 aatgtgaggt gttgctaaat atgttattgt ggaaagatga atgcaatagt aggactgctg 781 acattttgca gaaaatacat tttatttaaa aatctcctaa aaaaaaaaaa aaaaaaaaaa 841 aagaaaaaaa aaaaa 1 acattgtgaa atctccaact cttaaccttc aacatgaaag tctctgcagt gcttctgtgc 61 ctgctgctca tgacagcagc tttcaacccc cagggacttg ctcagccaga tgcactcaac 121 gtcccatcta cttgctgctt cacatttagc agtaagaaga tctccttgca gaggctgaag 181 agctatgtga tcaccaccag caggtgtccc cagaaggctg tcatcttcag aaccaaactg 241 ggcaaggaga tctgtgctga cccaaaggag aagtgggtcc agaattatat gaaacacctg 301 ggccggaaag ctcacaccct gaagacttga actctgctac ccctactgaa atcaagctgg 361 agtacgtgaa atgacttttc cattctcctc tggcctcctc ttctatgctt tggaatactt 421 ctaccataat tttcaaatag gatgcattcg gttttgtgat tcaaaatgta ctatgtgtta 481 agtaatattg gctattattt gacttgttgc tggtttggag tttatttgag tattgctgat 541 cttttctaaa gcaaggcctt gagcaagtag gttgctgtct ctaagccccc ttcccttcca WO 00/09525 PCT/US99/17712 EPI-109 1015 601 ctatgagctg ctggcagtgg gttgtattcg gttcccaggg gttgagagca tgcctgtggg 661 agtcatggac atgaagggat gctgcaatgt aggaaggaga gctctttgtg aatgtgaggt 721 tgttgctaaa ttattgttta ttgtggaaag atgaatgcaa tagtaggact gctgacattt 781 tgcagaaaat acattttatt taaaatctcc taaaaaaaaa aaaaa 1 aaaaggccgg cggaacagcc agaggagcag agaggcaaag aaacattgtg aaatctccaa 61 ctcttaacct tcaacatgaa agtctctgca gtgcttctgt gcctgctgct catgacagca 121 gctttcaacc cccagggact tgctcagcca gatgcactca acgtcccatc tacttgctgc 181 ttcacattta gcagtaagaa gatctccttg cagaggctga agagctatgt gatcaccacc 241 agcaggtgtc cccagaaggc tgtcatcttc agaaccaaac tgggcaagga gatctgtgct 301 gacccaaagg agaagtgggt ccagaattat atgaaacacc tgggccggaa agctcacacc 361 ctgaagactt gaactctgct acccctactg aaatcaagct ggagtacgtg aaatgacttt 421 tccattctcc tctggcctcc tcttctatgc tttggaatac ttctaccata attttcaaat 481 aggatgcatt cggttttgtg attcaaaatg tactatgtgt taagtaatat tggctattat 541 ttgacttgtt gctggtttgg agtttatttg agtattgctg atcttttcta aagcaaggcc 601 ttgagcaagt aggttgctgt ctctaagccc ccttcccttc cactatgagc tgctggcagt 661 gggtttgtat tcggttccca ggggttgaga gcatgcctgt gggagtcatg gacatgaagg 721 gatgctgcaa tgtaggaagg agagctcttt gtgaatgtga ggtgttgcta aatatgttat 781 tgtggaaaga tgaatgcaat agtaggactg ctgacatttt gcagaaaata cattttattt 841 aaaatctcca aaaaaaaaaa (2) INFORMATION FOR SEQ ID NO:2738: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2738 1 cgcccgggca ggtcctctgc ctagcactgc tcccccaagg ctcccagaaa tctcaggtca 61 gaggcacgga cagcctctgg agctctcgtc tggtgggacc atgaactgcc agcagctgtg 121 gctgggcttc ctactcccca tgacagtctc aggccgggtc ctggggcttg cagaggtggc 181 gcccgtggac tacctgtcac aatatgggta cctacagaag cctctagaag gatctaataa 241 cttcaagcca gaagatatca ccgaggctct gagagctttt caggaagcat ctgaacttcc 301 agtctcaggt cagctggatg atgccacaag ggcccgcatg aggcagcctc gttgtggcct 361 agaggatccc ttcaaccaga agacccttaa atacctgttg ctgggccgct ggagaaagaa 421 gcacctgact ttccgcatct tgaacctgcc ctccaccctt ccaccccaca cagcccgggc 481 agccctgcgt caagccttcc aggactggag caatgtggct cccttgacct tccaagaggt 541 gcaggctggt gcggctgaca tccgcctctc cttccatggc cgccaaagct cgtactgttc 601 caatactttt gatgggcctg ggagagtcct ggcccatgcc gacatcccag agctgggcag 661 tgtgcacttc gacgaagacg agttctggac tgaggggacc taccgtgggg tgaacctgcg 721 catcattgca gcccatgaag tgggccatgc tctggggctt gggcactccc gatattccca 781 ggccctcatg gccccagtct acgagggcta ccggccccac tttaagctgc acccagatga 841 tgtggcaggg atccaggctc tctatggcaa gaagagtcca gtgataaggg atgaggaaga 901 agaagagaca gagctgccca ctgtgccccc agtgcccaca gaacccagtc ccatgccaga 961 cccttgcagt agtgaactgg atgccatgat gctggggccc cgtgggaaga cctatgcttt 1021 caagggggac tatgtgtgga ctgtatcaga ttcaggaccg ggccccttgt tccgagtgtc 1081 tgccctttgg gaggggctcc ccggaaacct ggatgctgct gtctactcgc ctcgaacaca 1141 atggattcac ttctttaagg gagacaaggt gtggcgctac attaatttca agatgtctcc 1201 tggcttcccc aagaagctga ataggtcaga acctaacctg gatgcagctc tctattggcc 1261 tctcaaccaa aaggtgttcc tctttaaggg ctccgggtac tggcagtggg acgagctagc 1321 ccgaactgac ttcagcagct accccaaacc aatcaagggt ttgtttacgg gagtgccaaa 1381 ccagccctcg gctgctatga gttggcaaga tggccgagtc tacttcttca agggcaaagt 1441 ctactggcgc ctcaaccagc agcttcgagt agagaaaggc tatcccagaa atatttccca 1501 caactggatg cactgtcgtc cccggactat agacactacc ccatcaggtg ggaataccac 1561 tccctcaggt acgggcataa ccttggatac cactctctca gccacagaaa ccacgtttga 1621 atactgactg ctcacccaca gacacaatct tggacattaa cccctgaggc tccaccaccc 1681 accctttcat ttccccccca gaagcctaag gcctaatagc tgaatgaaat acctgtctgc 1741 tcagtagaac cttgcaggtg ctgtagcagg cgcaagaccg tagatctcag gcctctaaca 1801 cttccaactc cagccaccac tttcctgtgc attttcactc ctgagaagtg ctcccctaac 1861 tcagatcccc taacttagat ttggccccca actccatttc ctgtctgtct tagacagccc 1921 ttccaactgt gtcatctctt ctctggaggt caatggtgga gggagatgcc tgggtcctgt 1981 tcttcctaca taaaatgcaa gaaaacagca tggccagtaa actgagcaag ggccttggaa 2041 tccttgagaa tcacatttat gtgcttatga ttacgggcaa gctaattaac cttgttgaat 2101 ctcagattcc ccatttgcaa cattaggtta agaccagtac tgcaggattg ttgcactaaa 2161 tgaaatactg tatgtgaagt gcctggcaca gtgtctggta catttgtgtt taataaaagc 2221 taactccatg ttcataagaa aaaaaaaa (2) INFORMATION FOR SEQ ID'NO:2739: (1) SEQUENCE CHARACTERISTICS: (A) LENGTH: base pairs WO 00/09525 PCT/US99/17712 EPI-109 1016 (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2739 1 ggagaccggc cgcatggacc cagggacagt ggccaccatg cgtaagcccc gctgctccct 61 gcctgacgtg ctgggggtgg cggggctggt caggcggcgt cgccggtacg ctctgagcgg 121 cagcgtgtgg aagaagcgaa ccctgacatg gagggtacgt tccttccccc agagctccca 181 gctgagccag gagaccgtgc gggtcctcat gagctatgcc ctgatggcct ggggcatgga 241 gtcaggcctc acatttcatg aggtggattc cccccagggc caggagcccg acatcctcat 301 cgactttgcc cgcgccttcc accaggacag ctaccccttc gacgggttgg ggggcaccct 361 agcccatgcc ttcttccctg gggagcaccc catctccggg gacactcact ttgacgatga 421 ggagacctgg acttttgggt caaaagcctc tcagcagctg gagcaggagc tggcaggcgg 481 ctcaccggtt gatgaggagc tgggcttcag ccggggctgg cgtgtgaatc ctctgggtcc 541 tggcagtcct gagcgcctga gctgaataca gagggaagag gctgggagca aggccgggtg 601 ctggggccgg caggctgtgt tctgaga (2) INFORMATION FOR SEQ ID NO:2740: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2740 1 atgatcttac tcacattcag cactggaaga cggttggatt tcgtgcatca ttcgggggtg 61 tttttcttgc aaaccttgct ttggatttta tgtgctacag tctgcggaac ggagcagtat 121 ttcaatgtgg aggtttggtt acaaaagtac ggctaccttc caccgactga ccccagaatg 181 tcagtgctgc gctctgcaga gaccatgcag tctgccctag ctgccatgca gcagttctat 241 ggcattaaca tgacaggaaa agtggacaga aacacaattg actggatgaa gaagccccga 301 tgcggtgtac ctgaccagac aagaggtagc tccaaatttc atattcgtcg aaagcgatat 361 gcattgacag gacagaaatg gcagcacaag cacatcactt acagtataaa gaacgtaact 421 ccaaaagtag gagaccctga gactcgtaaa gctattcgcc gtgcctttga tgtgtggcag 481 aatgtaactc ctctgacatt tgaagaagtt ccctacagtg aattagaaaa tggcaaacgt 541 gatgtggata taaccattat ttttgcatct ggtttccatg gggacagctc tccctttgat 601 ggagagggag gatttttggc acatgcctac ttccctggac caggaattgg aggagatacc 661 cattttgact cagatgagcc atggacacta ggaaatccta atcatgatgg aaatgactta 721 tttcttgtag cagtccatga actgggacat gctctgggat tggagcattc caatgacccc 781 actgccatca tggctccatt ttaccagtac atggaaacag acaacttcaa actacctaat 841 gatgatttac agggcatcca gaagatatat ggtccacctg acaagattcc tccacctaca 901 agacctctac cgacagtgcc cccacaccgc tctattcctc cggctgaccc aaggaaaaat 961 gacaggccaa aacctcctcg gcctccaacc ggcagaccct cctatcccgg agccaaaccc 1021 aacatctgtg atgggaactt taacactcta gctattcttc gtcgtgagat gtttgttttc 1081 aaggaccagt ggttttggcg agtgagaaac aacagggtga tggatggata cccaatgcaa 1141 attacttact tctggcgggg cttgcctcct agtatcgatg cagtttatga aaatagcgac 1201 gggaattttg tgttctttaa agtgaaggga gacactctat ctgtaatcca agatggttgg 1261 ctctacaaat accattggaa atggattcta gaacaaaggc agtcagtgcc tgtgctctca 1321 agacaaactg aaaagcacaa gacctatgaa gaattatctt ccatcacata ctaacaaaga 1381 acaatcagga attgaaaatt taaaataaaa ggccatttac aattgcattc gaaaacacca 1441 aataccgagg gatcaatctg caaaaaatgt gcatgacctc tacattgaaa acaacaaaac 1501 actactaaat gtttgtcttt aaaggcagct gg (2) INFORMATION FOR SEQ ID NO:2741: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2741 1 tagaagttta caatgaagtt tcttctaata ctgctcctgc aggccactgc ttctggagct 61 cttcccctga acagctctac aagcctggaa aaaaataatg tgctatttgg tgagagatac 121 ttagaaaaat tttatggcct tgagataaac aaacttccag tgacaaaaat gaaatatagt 181. ggaaacttaa tgaaggaaaa aatccaagaa atgcagcact tcttgggtct gaaagtgacc 241 gggcaactgg acacatctac cctggagatg atgcacgcac ctcgatgtgg agtccccgat 301 ctccatcatt tcagggaaat gccagggggg cccgtatgga ggaaacatta tatcacctac 361 agaatcaata attacacacc tgacatgaac cgtgaggatg ttgactacgc aatccggaaa 421 gctttccaag tatggagtaa tgttaccccc ttgaaattca gcaagattaa cacaggcatg 481 gctgacattt tggtggtttt tgcccgtgga gctcatggag acttccatgc ttttgatggc 541 aaaggtggaa tccaagccca tgcttttgga cctggactg gcattggagg ggatgcacat 601 ttcgatgagg acgaattctg gactacacat tcaggaggca caaacttgtt cctcactgct 661 gttcacgaga ttggccattc cttaggtctt ggccattcta gtgatccaaa ggctgtaatg 721 ttccccacct acaaatatgt cgacatcaac acatttcgcc tctctgctga tgacatacgt WO 00/09525 PCT/US99/17712 EPI-109 1017 781 ggcattcagt ccctgtatgg agacccaaaa gagaaccaac gcttgccaaa tcctgacaat 841 tcagaaccag ctctctgrga ccccaatttg agttttgatg ctgtcactac cgtgggaaat 901 aagatctttt tcttcaaaga caggttcttc tggctgaagg tttctgagag accaaagacc 961 agtgttaatt taatttcttc cttatggcca accttgccat ctggcattga agctgcttat 1021 gaaattgaag ccagaaatca agtttttctt tttaaagatg acaaatactg gttaattagc 1081 aatttaagac cagagccaaa ttatcccaag agcatacatt cttttggttt tcctaacttt 1141 gtgaaaaaaa ttgatgcagc tgtttttaac ccacgttttt ataggaccta cttctttgta 1201 gataaccagt attggaggta tgatgaaagg agacagatga tggaccctgg ttatcccaaa 1261 ctgattacca agaacttcca aggaatcggg cctaaaattg atgcagtctt ctattctaaa 1321 aacaaatact actatttctt ccaaggatct aaccaatttg aatatgactt cctactccaa 1381 cgtatcacca aaacactgaa aagcaatagc tggtttggtt gttagaaatg gtgtaattaa 1441 tggtttttgt tagttcactt cagcttaata agtatttatt gcatatttgc tatgtcctca 1501 gtgtaccact acttagagat atgtatcata aaaataaaat ctgtaaacca taggtaatga 1561 ttatataaaa tacataatat ttttcaattt tgaaaactct aattgtccat tcttgcttga 1621 ctctactatt aagtttgaaa atagttacct tcaaagcaag ataattctat ttgaagcatg 1681 ctctgtaagt tgcttcctaa catccttgga ctgagaaatt atacttactt ctggcataac 1741 taaaattaag tatatatatt ttggctcaaa taaaattg (2) INFORMATION FOR SEQ ID NO:2742: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2742 1 aaagaaggta agggcagtga gaatgatgca tcttgcattc cttgtgctgt tgtgtctgcc 61 agtctgctct gcctatcctc tgagtggggc agcaaaagag gaggactcca acaaggatct 121 tgcccagcaa tacctagaaa agtactacaa cctcgaaaag gatgtgaaac agtttagaag 181 aaaggacagt aatctcatcg ttaaaaaaat ccaaggaatg cagaagttcc ttgggttgga 241 ggtgacaggg aagctagaca ctgacactct ggaggtgatg cgcaagccca ggtgtggagt 301 tcctgacgtt ggtcacttca gctcctttcc tggcatgccg aagtggagga aaacccacct 361 tacatacagg attgtgaatt atacaccaga tttgccaaga gatgctgttg attctgccat 421 tgagaaagct ctgaaagtct gggaagaggt gactccactc acattctcca ggctgtatga 481 aggagaggct gatataatga tctctttcgc agttaaagaa catggagact tttactcttt 541 tgatggccca ggacacagtt tggctcatgc ctacccacct ggacctgggc tttatggaga 601 tattcacttt gatgatgatg aaaaatggac agaagatgca tcaggcacca atttattcct 661 cgttgctgct catgaacttg gccactccct ggggctcttt cactcagcca acactgaagc 721 tttgatgtac ccactctaca actcattcac agagctcgcc cagttccgcc tttcgcaaga 781 tgatgtgaat ggcattcagt ctctctacgg acctccccct gcctctactg aggaacccct 841 ggtgcccaca aaatctgttc cttcgggatc tgagatgcca gccaagtgtg atcctgcttt 901 gtccttcgat gccatcagca ctctgagggg agaatatctg ttctttaaag acagatattt 961 ttggcgaaga tcccactgga accctgaacc tgaatttcat ttgatttctg cattttggcc 1021 ctctcttcca tcatatttgg atgctgcata tgaagttaac agcagggaca ccgtttttat 1081 ttttaaagga aatgagttct gggccatcag aggaaatgag gtacaagcag gttatccaag 1141 aggcatccat accctgggtt ttcctccaac cataaggaaa attgatgcag ctgtttctga 1201 caaggaaaag aagaaaacat acttctttgc agcggacaaa tactggagat ttgatgaaaa 1261 tagccagtcc atggagcaag gcttccctag actaatagct gatgactttc caggagttga 1321 gcctaaggtt gatgctgtat tacaggcatt tggatttttc tacttcttca gtggatcatc 1381 acagtttgag tttgacccca atgccaggat ggtgacacac atattaaaga gtaacagctg 1441 gttacattgc taggcgagat agggggaaga cagatatggg tgtttttaat aaatctaata 1501 attattcatc taatgtatta tgagccaaaa tggttaattt ttcctgcatg ttctgtgact 1561 gaagaagatg agccttgcag atatctgcat gtgtcatgaa gaatgtttct ggaattcttc 1621 acttgctttt gaattgcact gaacagaatt aagaaatact catgtgcaat aggtgagaga 1681 atgtattttc atagatgtgt tattacttcc tcaataaaaa gttttatttt gggcctgttc 1741 ctt (2) INFORMATION FOR SEQ ID NO:2743: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: _base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2743 1 ctgaggtggg taagagtaca atggctaaat cttaacacac tcttacgtgt acaccctacc 61 gtacaccatc cagactcgtc cccatacaat caggagtgat cagtacgtaa atgcttatgg 121 tgtgatttga aggggtgtta gagtagatca tctctcacac cgcagcagca ctgcttccaa 181 ttcatccttt ggaattttat tccctgactg ttaaaagttt ttagtgctta aatattctct 241 attgaggtaa gagacagatt ctgtgcaatg ggacaattag gtcaagaggg aaagaagctg 301 aggtgatagg cagatagatt ccagaggcaa acttttccca tctgctaaag ttgaaaagag WO 00/09525 PCTIUS99/17712 EPI-109 1018 361 taacccacat cctaccaacg ctagacaatc taggatgtag ggaaagtttg tctctggaat 421 ctatccaggt acccagttgg gactgagctt cagcttagat gtctgaagat gttaagttat 481 agaatcaggt ttaagtctga agatgttaag ttatagaatc aggatctgag ccggtacaac 541 acgtggataa acaatgaagt cgatgttaca aatttttttt tgctacttgt aaaatctctg 601 tatcacattt ctctagggag ctggattccg tttaggagca ctcatttact ccaggaaaag 661 gattttattt aatctttcaa catttacttt aaaaactttt tttatctata atgaatataa 721 ggaagtatta taatgaaaac caagttatca ggctttaaga aaatatattt taagttctcc 781 ttctctttta gttgcttgat atttctttta caagggctta ttttgtagat aggtggacgt 841 agaggcttat ttatcatttt gaaggtacat actctgaatt gcttgagtga tggactagat 901 gctaattgat ccattgtcgt ctgaataaag tcatgctttt gtttgcatgt ttttagagat 961 agtcaaggga tgatatcaac tatgagtcac tcataggatt catattcaca gaacccggac 1021 taagggctat ataaagagga acagttcagg aacttaggct agaaaggaca cagtaaactg 1081 aattgatccg tttagaagtt tacaatgaag tttcttctaa tactgctcct gcaggccact 1141 gcttctggag ctcttcccct gaacagctct acaagcctgg aaaaaaataa tgtgctattg 1201 ggtgagaga (2) INFORMATION FOR SEQ ID NO:2744: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2744 1 cgcccgggca ggtcctctgc ctagcactgc tcccccaagg ctcccagaaa tctcaggtca 61 gaggcacgga cagcctctgg agctctcgtc tggtgggacc atgaactgcc agcagctgtg 121 gctgggcttc ctactcccca tgacagtctc aggccgggtc ctggggcttg cagaggtggc 181 gcccgtggac tacctgtcac aatatgggta cctacagaag cctctagaag gatctaataa 241 cttcaagcca gaagatatca ccgaggctct gagagctttt caggaagcat ctgaacttcc 301 agtctcaggt cagctggatg atgccacaag ggcccgcatg aggcagcctc gttgtggcct 361 agaggatccc ttcaaccaga agacccttaa atacctgttg ctgggccgct ggagaaagaa 421 gcacctgact ttccgcatct tgaacctgcc ctccaccctt ccaccccaca cagcccgggc 481 agccctgcgt caagccttcc aggactggag caatgtggct cccttgacct tccaagaggt 541 gcaggctggt gcggctgaca tccgcctctc cttccatggc cgccaaagct cgtactgttc 601 caatactttt gatgggcctg ggagagtcct ggcccatgcc gacatcccag agctgggcag 661 tgtgcacttc gacgaagacg agttctggac tgaggggacc taccgtgggg tgaacctgcg 721 catcattgca gcccatgaag tgggccatgc tctggggctt gggcactccc gatattccca 781 ggccctcatg gccccagtct acgagggcta ccggccccac tttaagctgc acccagatga 841 tgtggcaggg atccaggctc tctatggcaa gaagagtcca gtgataaggg atgaggaaga 901 agaagagaca gagctgccca ctgtgccccc agtgcccaca gaacccagtc ccatgccaga 961 cccttgcagt agtgaactgg atgccatgat gctggggccc cgtgggaaga cctatgcttt 1021 caagggggac tatgtgtgga ctgtatcaga ttcaggaccg ggccccttgt tccgagtgtc 1081 tgccctttgg gaggggctcc ccggaaacct ggatgctgct gtctactcgc ctcgaacaca 1141 atggattcac ttctttaagg gagacaaggt gtggcgctac attaatttca agatgtctcc 1201 tggcttcccc aagaagctga ataggtcaga acctaacctg gatgcagctc tctattggcc 1261 tctcaaccaa aaggtgttcc tctttaaggg ctccgggtac tggcagtggg acgagctagc 1321 ccgaactgac ttcagcagct accccaaacc aatcaagggt ttgtttacgg gagtgccaaa 1381 ccagccctcg gctgctatga gttggcaaga tggccgagtc tacttcttca agggcaaagt 1441 ctactggcgc ctcaaccagc agcttcgagt agagaaaggc tatcccagaa atatttccca 1501 caactggatg cactgtcgtc cccggactat agacactacc ccatcaggtg ggaataccac 1561 tccctcaggt acgggcataa ccttggatac cactctctca gccacagaaa ccacgtttga 1621 atactgactg ctcacccaca gacacaatct tggacattaa cccctgaggc tccaccaccc 1681 accctttcat ttccccccca gaagcctaag gcctaatagc tgaatgaaat acctgtctgc 1741 tcagtagaac cttgcaggtg ctgtagcagg cgcaagaccg tagatctcag gcctctaaca 1801 cttccaactc cagccaccac tttcctgtgc attttcactc ctgagaagtg ctcccctaac 1861 tcagatcccc taacttagat ttggccccca actccatttc ctgtctgtct tagacagccc 1921 ttccaactgt gtcatctctt ctctggaggt caatggtgga gggagatgcc tgggtcctgt 1981 tcttcctaca taaaatgcaa gaaaacagca tggccagtaa actgagcaag ggccttggaa 2041 tccttgagaa tcacatttat gtgcttatga ttacgggcaa gctaattaac cttgttgaat 2101 ctcagattcc ccatttgcaa cattaggtta agaccagtac tgcaggattg ttgcactaaa 2161 tgaaatactg tatgtgaagt gcctggcaca gtgtctggta catttgtgtt taataaaagc 2221 taactccatg ttcataagaa aaaaaaaa 1 ggagaccggc cgcatggacc cagggacagt ggccaccatg cgtaagcccc gctgctccct 61 gcctgacgtg ctgggggtgg cggggctggt caggcggcgt cgccggtacg ctctgagcgg 121 cagcgtgtgg aagaagcgaa ccctgacatg gagggtacgt tccttccccc agagctccca 181 gctgagccag gagaccgtgc gggtcctcat gagctatgcc ctgatggcct ggggcatgga 241 gtcaggcctc acatttcatg aggtggattc cccccagggc caggagcccg acatcctcat 301 cgactttgcc cgcgccttcc accaggacag ctaccccttc gacgggttgg ggggcaccct 361 agcccatgcc ttcttccctg gggagcaccc catctccgqg gacactcact ttgacgatga 421 ggagacccgg acttttgggt caaaagcctc tcagcagctg gagcaggagc tggcaggcgg WO 00/09525 PCT/US99/17712 EPI-109 1019 481 ctcaccggtt gatgaggagc tgggcttcag ccggggctgg cgtgtgaatc ctctgggtcc 541 tggcagtcct gagcgcctga gctgaataca gagggaagag gctgggagca aggccgggtg 601 ctggggccgg caggctgtgt tctgaga 1 atgatcttac tcacattcag cactggaaga cggttggatt tcgtgcatca ttcgggggtg 61 tttttcttgc aaaccttgct ttggatttta tgtgctacag tctgcggaac ggagcagtat 121 ttcaatgtgg aggtttggtt acaaaagtac ggctaccttc caccgactga ccccagaatg 181 tcagtgctgc gctctgcaga gaccatgcag tctgccctag ctgccatgca gcagttctat 241 ggcattaaca tgacaggaaa agtggacaga aacacaattg actggatgaa gaagccccga 301 tgcggtgtac ctgaccagac aagaggtagc tccaaatttc atattcgtcg aaagcgatat 361 gcattgacag gacagaaatg gcagcacaag cacatcactt acagtataaa gaacgtaact 421 ccaaaagtag gagaccctga gactcgtaaa gctattcgcc gtgcctttga tgtgtggcag 481 aatgtaactc ctctgacatt tgaagaagtt ccctacagtg aattagaaaa tggcaaacgt 541 gatgtggata taaccattat ttttgcatct ggtttccatg gggacagctc tccctttgat 601 ggagagggag gatttttggc acatgcctac ttccctggac caggaattgg aggagatacc 661 cattttgact cagatgagcc atggacacta ggaaatccta atcatgatgg aaatgactta 721 tttcttgtag cagtccatga actgggacat gctctgggat tggagcattc caatgacccc 781 actgccatca tggctccatt ttaccagtac atggaaacag acaacttcaa actacctaat 841 gatgatttac agggcatcca gaagatatat ggtccacctg acaagattcc tccacctaca 901 agacctctac cgacagtgcc cccacaccgc tctattcctc cggctgaccc aaggaaaaat 961 gacaggccaa aacctcctcg gcctccaacc ggcagaccct cctatcccgg agccaaaccc 1021 aacatctgtg atgggaactt taacactcta gctattcttc gtcgtgagat gtttgttttc 1081 aaggaccagt ggttttggcg agtgagaaac aacagggtga tggatggata cccaatgcaa 1141 attacttact tctggcgggg cttgcctcct agtatcgatg cagtttatga aaatagcgac 1201 gggaattttg tgttctttaa agtgaaggga gacactctat ctgtaatcca agatggttgg 1261 ctctacaaat accattggaa atggattcta gaacaaaggc agtcagtgcc tgtgctctca 1321 agacaaactg aaaagcacaa gacctatgaa gaattatctt ccatcacata ctaacaaaga 1381 acaatcagga attgaaaatt taaaataaaa ggccatttac aattgcattc gaaaacacca 1441 aataccgagg gatcaatctg caaaaaatgt gcatgacctc tacattgaaa acaacaaaac 1501 actactaaat gtttgtcttt aaaggcagct gg 1 tagaagttta caatgaagtt tcttctaata ctgctcctgc aggccactgc ttctggagct 61 cttcccctga acagctctac aagcctggaa aaaaataatg tgctatttgg tgagagatac 121 ttagaaaaat tttatggcct tgagataaac aaacttccag tgacaaaaat gaaatatagt 181 ggaaacttaa tgaaggaaaa aatccaagaa atgcagcact tcttgggtct gaaagtgacc 241 gggcaactgg acacatctac cctggagatg atgcacgcac ctcgatgtgg agtccccgat 301 ctccatcatt tcagggaaat gccagggggg cccgtatgga ggaaacatta tatcacctac 361 agaatcaata attacacacc tgacatgaac cgtgaggatg ttgactacgc aatccggaaa 421 gctttccaag tatggagtaa tgttaccccc ttgaaattca gcaagattaa cacaggcatg 481 gctgacattt tggtggtttt tgcccgtgga gctcatggag acttccatgc ttttgatggc 541 aaaggtggaa tcctagccca tgcttttgga cctggatctg gcattggagg ggatgcacat 601 ttcgatgagg acgaattctg gactacacat tcaggaggca caaacttgtt cctcactgct 661 gttcacgaga ttggccattc cttaggtctt ggccattcta gtgatccaaa ggctgtaatg 721 ttccccacct acaaatatgt cgacatcaac acatttcgcc tctctgctga tgacatacgt 781 ggcattcagt ccctgtatgg agacccaaaa gagaaccaac gcttgccaaa tcctgacaat 841 tcagaaccag ctctctgtga ccccaatttg agttttgatg ctgtcactac cgtgggaaat 901 aagatctttt tcttcaaaga caggttcttc tggctgaagg tttctgagag accaaagacc 961 agtgttaatt taatttcttc cttatggcca accttgccat ctggcattga agctgcttat 1021 gaaattgaag ccagaaatca agtttttctt tttaaagatg acaaatactg gttaattagc 1081 aatttaagac cagagccaaa ttatcccaag agcatacatt cttttggttt tcctaacttt 1141 gtgaaaaaaa ttgatgcagc tgtttttaac ccacgttttt ataggaccta cttctttgta 1201 gataaccagt attggaggta tgatgaaagg agacagatga tggaccctgg ttatcccaaa 1261 ctgattacca agaacttcca aggaatcggg cctaaaattg atgcagtctt ctattctaaa 1321 aacaaatact actatttctt ccaaggatct aaccaatttg aatatgactt cctactccaa 1381 cgtatcacca aaacactgaa aagcaatagc tggtttggtt gttagaaatg gtgtaattaa 1441 tggtttttgt tagttcactt cagcttaata agtatttatt gcatatttgc tatgtcctca 1501 gtgtaccact acttagagat atgtatcata aaaataaaat ctgtaaacca taggtaatga 1561 ttatataaaa tacataatat ttttcaattt tgaaaactct aattgtccat tcttgcttga 1621 ctctactatt aagtttgaaa atagttacct tcaaagcaag ataattctat ttgaagcatg 1681 ctctgtaagt tgcttcctaa catccttgga ctgagaaatt atacttacct ctggcataac 1741 taaaattaag tatatatatt ttggctcaaa taaaattg 1 aaagaaggta agggcagtga gaatgatgca tcttgcattc cttgtgctgt tgtgtctgcc 61 agtctgctct gcctatcctc tgagtggggc agcaaaagag gaggactcca acaaggatct 121 tgcccagcaa tacctagaaa agtactacaa cctcgaaaag gatgtgaaac agtttagaag 181 aaaggacagt aatctcattg ttaaaaaaat ccaaggaatg cagaagttcc ttgggttgga 241 ggtgacaggg aaqctagaca ctgacactct ggaggtgatg cgcaagccca ggtgtggagt 301 tcctgacgtt ggtcacttca gctcctttcc tggcatgccg aagtggagga aaacccacct 361 tacatacagg attgtgaatt atacaccaga tttgccaaga gatgctgttg attctgccat 421 tgagaaagct ctgaaagtct gggaagaggt gactccactc acattctcca ggctgtatga 481 aggagaggct gatataatga tctctttcgc agttaaagaa catggagact tttactcttt WO 00/09525 PCT/US99/17712 EPI-109 1020 541 tgatggccca ggacacagtt tggctcatgc ctacccacct ggacctgggc tttatggaga 601 tattcacttt gatgatgatg aaaaatggac agaagatgca tcaggcacca atttattcct 661 cgttgctgct catgaacttg gccactccct ggggctcttt cactcagcca acactgaagc 721 tttgatgtac ccactctaca actcattcac agagctcgcc cagttccgcc tttcgcaaga 781 tgatgtqaac ggcattcagt ctctctacgg acctccccct gcctctactg aggaacccct 841 ggtgcccaca aaatctgttc cttcgggatc tgagatgcca gccaagtgtg atcctgcttt 901 gtccttcgat gccatcagca ctctgagggg agaatatctg ttctttaaag acagatattt 961 ttggcgaaga tcccactgga accctgaacc tgaatttcat ttgatttctg cattttggcc 1021 ctctcttcca tcatatttgg atgctgcata tgaagttaac agcagggaca ccgtttttat 1081 ttttaaagga aatgagttct gggccatcag aggaaatgag gtacaagcag gttatccaag 1141 aggcatccat accctgggtt ttcctccaac cataaggaaa attgatgcag ctgtttctga 1201 caaggaaaag aagaaaacat acttctttgc agcggacaaa tactggagat ttgatgaaaa 1261 tagccagtcc atggagcaag gcttccctag actaatagct gatgactttc caggagttga 1321 gcctaaggtt gatgctgtat tacaggcatt tggatttttc tacttcttca gtggatcatc 1381 acagtttgag tttgacccca atgccaggat ggtgacacac atattaaaga gtaacagctg 1441 gttacattgc taggcgagat agggggaaga cagatatggg tgtttttaat aaatctaata 1501 attattcatc taatgtatta tgagccaaaa tggttaattt ttcctgcatg ttctgtgact 1561 gaagaagatg agccttgcag atatctgcat gtgtcatgaa gaatgtttct ggaattcttc 1621 acttgctttt gaattgcact gaacagaatt aagaaatact catgtgcaat aggtgagaga 1681 atgtattttc atagatgtgt tattacttcc tcaataaaaa gttttatttt gggcctgttc 1741 ctt 1 ctgaggtggg taagagtaca atggctaaat cttaacacac tcttacgtgt acaccctacc 61 gtacaccatc cagactcgtc cccatacaat caggagtgat cagtacgtaa atgcttatgg 121 tgtgatttga aggggtgtta gagtagatca tctctcacac cgcagcagca ctgcttccaa 181 ttcatccttt ggaattttat tccctgactg ttaaaagttt ttagtgctta aatattctct 241 attgaggtaa gagacagat~t ctgtgcaatg ggacaattag gtcaagaggg aaagaagctg 301 aggtgatagg cagatagatt ccagaggcaa acttttccca tctgctaaag ttgaaaagag 361 taacccacat cctaccaacg ctagacaatc taggatgtag ggaaagtttg tctctggaat 421 ctatccaggt acccagttgg gactgagctt cagcttagat gtctgaagat gttaagttat 481 agaatcaggt ttaagtctga agatgttaag ttatagaatc aggatctgag ccggtacaac 541 acgtggataa acaatgaagt cgatgttaca aatttttttt tgctacttgt aaaatctctg 601 tatcacattt ctctagggag ctggattccg tttaggagca ctcatttact ccaggaaaag 661 gattttattt aatctttcaa catttacttt aaaaactttt tttatctata atgaatataa 721 ggaagtatta taatgaaaac caagttatca ggctttaaga aaatatattt taagttctcc 781 ttctctttta gttgcttgat atttctttta caagggctta ttttgtagat aggtggacgt 841 agaggcttat ttatcatttt gaaggtacat actctgaatt gcttgagtga tggactagat 901 gctaattgat ccattgtcgt ctgaataaag tcatgctttt gtttgcatgt ttttagagat 961 agtcaaggga tgatatcaac tatgagtcac tcataggatt catattcaca gaacccggac 1021 taagggctat ataaagagga acagttcagg aacttaggct agaaaggaca cagtaaactg 1081 aattgatccg tttagaagtt tacaatgaag tttcttctaa tactgctcct gcaggccact 1141 gcttctggag ctcttcccct gaacagctct acaagcctgg aaaaaaataa tgtgctattg 1201 ggtgagaga (2) INFORMATION FOR SEQ ID NO:2745: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2745 1 aaggacacgg gcagcagaca gtggtcagtc ctttcttggc tctgctgaca ctcgagccca 61 cattccgtca cctgctcaga atcatgcagg tctccactgc tgcccttgct gtcctcctct 121 gcaccatggc tctctgcaac cagttctctg catcacttgc tgctgacacg ccgaccgcct 181 gctgcttcag ctacacctcc cggcagattc cacagaattt catagctgac tactttgaga 241 cgagcagcca gtgctccaag cccggtgtca tcttcctaac caagcgaagc cggcaggtct 301 gtgctgaccc cagtgaggag tgggtccaga aatatgtcag cgacctagag ctgagtgcct 361 gaggggtcca gaagcttcga ggcccagcga cctcggtggg ccagtgggga ggagcaggag 421 cctgagcctt gggaaacatg cgtgtgacct ccacagctac ctcttctatg gactggttgt 481 tgccaaacag ccacactgtg ggactcttct taacttaaat tttaatttat ttatactatt 541 tagtttttgt aatttatttt cgatttcaca gtgtgtttgt gattgtttgc tctgagagtt 601 cccctgtccc ctcccccttc cctcacaccg cgtctggtga caaccgagtg gctgtcatca 661 gcctgtgtag gcagtcatgg caccaaagcc accagactga caaatgtgta tcggatgctt 721 ttgttcaggg ctgtgatcgg cctggggaaa taataaagca cgctctttta aaaggt (2) INFORMATION FOR SEQ ID NO:2746: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: _base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single WO 00/09525 PCTIUS99/17712 EPI-109 1021 (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2746 1 acagccttga ccttatgtca tgggttcaac ttggacactg aaaacgcaat gaccttccaa 61 gagaacqcaa ggggcttcgg gcagagcgtg gtccagcttc agggatccag ggtggtggtt 121 ggagcccccc aggagatagt ggctgccaac caaaggggca gcctctacca gtgcgactac 181 agcacaggct catgcgagcc catccgcctg caggtccccg tggaggccgt gaacatgtcc 241 ctgggcctgt ccctggcagc caccaccagc ccccctcagc tgctggcctg tggtcccacc 301 gtgcaccaga cttgcagtga gaacacgtat gtgaaagggc tctgcttcct gtttggatcc 361 aacctacggc agcagcccca gaagttccca gaggccctcc gagggtgtcc tcaagaggat 421 agtgacattg ccttcttgat tgatggctct ggtagcatca tcccacatga ctttcggcgg 481 atgaaggagt ttgtctcaac tgtgatggag caattaaaaa agtccaaaac cttgttctct 541 ttgatgcagt actctgaaga attccggatt cactttacct tcaaagagtt ccagaacaac 601 cctaacccaa gatcactggt gaagccaata acgcagctgc ttgggcggac acacacggcc 661 acgggcatcc gcaaagtggt acgagagctg tttaacatca ccaacggagc ccgaaagaat 721 gcctttaaga tcctagttgt catcacggat ggagaaaagt ttggcgatcc cttgggatat 781 gaggatgtca tccctgaggc agacagagag ggagtcattc gctacgtcat tggggtggga 841 gatgccttcc gcagtgagaa atcccgccaa gagcttaata ccatcgcatc caagccgcct 901 cgtgatcacg tgttccaggt gaataacttt gaggctctga agaccattca gaaccagctt 961 cgggagaaga tctttgcgat cgagggtact cagacaggaa gtagcagctc ctttgagcat 1021 gagatgtctc aggaaggctt cagcgctgcc atcacctcta atggcccctt gctgagcact 1081 gtggggagct atgactgggc tggtggagtc tttctatata catcaaagga gaaaagcacc 1141 ttcatcaaca tgaccagagt ggattcagac atgaatgatg cttacttggg ttatgctgcc 1201 gccatcatct tacggaaccq ggtgcaaagc ctggttctgg gggcacctcg atatcagcac 1261 atcggcctgg tagcgatgtt caggcagaac actggcatgt gggagtccaa cgctaatgtc 1321 aagggcaccc agatcggcgc ctacttcggg gcctccctct gctccgtgga cgtggacagc 1381 aacggcagca ccgacctggt cctcatcggg gccccccatt actacgagca gacccgaggg 1441 ggccaggtgt ccgtgtgccc cttgcccagg gggcagaggg ctcggtggca gtgtgatgct 1501 gttctctacg gggagcaggg ccaaccctgg ggccgctttg gggcagccct aacagtgctg 1561 ggggacgtaa atggggacaa gctgacggac gtggccattg gggccccagg agaggaggac 1621 aaccggggtg ctgtttacct gtttcacgga acctcaggat ctggcatcag cccctcccat 1681 agccagcgga tagcaggctc caagctctct cccaggctcc agtattttgg tcagtcactg 1741 agtgggggcc aggacctcac aatggatgga ctggtagacc tgactgtagg agcccagggg 1801 cacgtgctgc tgctcaggtc ccagccagta ctgagagtca aggcaatcat ggagttcaat 1861 cccagggaag tggcaaggaa tgtatttgag tgtaatgatc aggtggtgaa aggcaaggaa 1921 gccggagagg tcagagtctg cctccatgtc cagaagagca cacgggatcg gctaagagaa 1981 ggacagatcc agagtgttgt gacttatgac ctggctctgg actccggccg cccacattcc 2041 cgcgccgtct tcaatgagac aaagaacagc acacgcagac agacacaggt cttggggctg 2101 acccagactt gtgagaccct gaaactacag ttgccgaatt gcatcgagga cccagtgagc 2161 cccattgtgc tgcgcctgaa cttctctctg gtgggaacgc cattgtctgc tttcgggaac 2221 ctccggccag tgctggcgga ggatgctcag agactcttca cagccttgtt tccctttgag 2281 aagaattgtg gcaatgacaa catctgccag gatgacctca gcatcacctt cagtttcatg 2341 agcctggact gcctcgtggt gggtgggccc cgggagttca acgtgacagt gactgtgaga 2401 aatgatggtg aggactccta caggacacag gtcaccttct tcttcccgct tgacctgtcc 2461 taccggaagg tgtccacgct ccagaaccag cgctcacagc gatcctggcg cctggcctgt 2521 gagtctgcct cctccaccga agtgtctggg gccttgaaga gcaccagctg cagcataaac 2581 caccccatct tcccggaaaa ctcagaggtc acctttaata tcacgtttga tgtagactct 2641 aaggcttccc ttggaaacaa actgctcctc aaggccaatg tgaccagtga gaacaacatg 2701 cccagaacca acaaaaccga attccaactg gagctgccgg tgaaatatgc tgtctacatg 2761 gtggtcacca gccatggggt ctccactaaa tatctcaact tcacggcctc agagaatacc 2821 agtcgggtca tgcagcatca atatcaggtc agcaacctgg ggcagaggag cctccccatc 2881 agcctggtgt tcttggtgcc cgtccggctg aaccagactg tcatatggga ccgcccccag 2941 gtcaccttct ccgagaacct ctcgagtacg tgccacacca aggagcgctt gccctctcac 3001 tccgactttc tggctgagct tcggaaggcc cccgtggtga actgctccat cgctgtctgc 3061 cagagaatcc agtgtgacat cccgttcttt ggcatccagg aagaattcaa tgctaccctc 3121 aaaggcaacc tctcgtttga ctggtacatc aagacctcgc ataaccacct cctgatcgtg 3181 agcacagctg agatcttgtt taacgattcc gtgttcaccc tgctgccggg acagggggcg 3241 tttgtgaggt cccagacgga gaccaaagtg gagccgttcg aggtccccaa ccccctgccg 3301 ctcatcgtgg gcagctctgt cgggggactg ctgctcctgg ccctcatcac cgccgcgctg 3361 tacaagctcg gcttcttca 'a gcggcaatac aaggacatga tgagtgaagg gggtcccccg 3421 ggggccgaac cccagtagcg gctccttccc gacagagctg cctctcggtg gccagcagga 3481 ctctgcccag accacacgta gcccccaggc tgctggacac gtcggacagc gaagtatccc 3541 cgacaggacg ggcttgggct tccatttgtg tgtgtgcaag tgtgtatgtg cgtgtgtgcg 3601 agtgtgtgca agtgtctgtg tgcaagtgtg tgcacgtgtc ggtgtgcgtg catgtgcact 3661 cgcacgccca tgtgtgagtg tgtgcaagta tgtgagtgtg tccaagtgtg tgtgcgtgtg 3721 tccatgtgtg tgcaagtgtg tgcatgtgtg cgagtgtgtg catgtgtgtg ctcaggggcg 3781 tgtggctcac gtgtgtgact cagatgtctc tggcgtgtgg gtaggtgacg gccagcgtag 3841 cctctccggc agaagggaac tgcctgggct cccttgtgcg tgggtgaagc cgctgctggg 3901 ttttcctccg ggagagggga cggtcaatcc tgtgggtgaa gacagaggga aacacagcag WO 00/09525 PCT/US99/17712 EPI-109 1022 3961 cttctctcca ctgaaagaag tgggacttcc cgtcgcctgc agcctgcggc ctgctggagc 4021 ctgcgcagct tggatggaga ctccatgaga agccgtgggt ggaaccagga gcctcctcca 4081 caccagcgct gatgcccaat aaagatgccc actgaggaat gatg (2) INFORMATION FOR SEQ ID NO:2747: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2747 1 agcaggaagc tcgcgccgcc gtcgccgccg ccgctcagct tccccgggcg cgtccaggac 61 ccgctgcgcc aggcgcgccg tccccggacc cggcgtgcgc ccctacgagg aaagggaccc 121 cgccgctcga gccgcctccg ccagccccac tgcgaggggt cccagagcca gccgcgcccg 181 ccctcgcccc cggccccgca gccttcccgc cctgcgcgcc atgaacgccc ccgagcggca 241 gccccaaccc gacggcgggg acgccccagg ccacgagcct gggggcagcc cccaagacga 301 gcttgacttc tccatcctct tcgactatga gtatttgaat ccgaacgaag aagagccgaa 361 tgcacataag gtcgccagcc caccctccgg acccgcatac cccgatgatg taatggacta 421 tggcctcaag ccatacagcc cccttgctag tctctctggc gagccccccg gccgattcgg 481 agagccggat agggtagggc cgcagaagtt tctgagcgcg gccaagccag caggggcctc 541 gggcctgagc cctcggatcg agatcactcc gtcccacgaa ctgatccagg cagtggggcc 601 cctccgcatg agagacgcgg gcctcctggt ggagcagcct cccctggccg gggtggccgc 661 cagcccgagg ttcaccctgc ccgtgcccgg cttcgagggc taccgcgagc cgctttgctt 721 gagccccgct agcagcggct cctctgccag cttcatttct gacaccttct ccccctacac 781 ctcgccctgc gtctcgccca ataacggcgg gcccgacgac ctgtgtccgc agtttcaaaa 841 catccctgct cattattccc ccagaacctc gccaataatg tcacctcgaa ccagcctcgc 901 cgaggacagc tgcctgggcc gccactcgcc cgtgccccgt ccggcctccc gctcctcatc 961 gcctggtgcc aagcggaggc attcgtgcgc cgaggccttg gttgccctgc cgcccggagc 1021 ctcaccccag cgctcccgga gcccctcgcc gcagccctca tctcacgtgg caccccagga 1081 ccacggctcc ccggctgggt acccccctgt ggctggctct gccgtgatca tggatgccct 1141 gaacagcctc gccacggact cgccttgtgg gatccccccc aagatgtgga agaccagccc 1201 tgacccctcg ccggtgtctg ccgccccatc caaggccggc ctgcctcgcc acatctaccc 1261 ggccgtggag ttcctggggc cctgcgagca gggcgagagg agaaactcgg ctccagaatc 1321 catcctgctg gttccgccca cttggcccaa gccgctggtg cctgccattc ccatctgcag 1381 catcccagtg actgcatccc tccctccact tgagtggccg ctgtccagtc agtcaggctc 1441 ttacgagctg cggatcgagg tgcagcccaa gccacatcac cgggcccact atgagacaga 1501 aggcagccga ggggctgtca aagctccaac tggaggccac cctgtggttc agctccatgg 1561 ctacatggaa aacaagcctc tgggacttca gatcttcatt gggacagctg atgagcggat 1621 ccttaagccg cacgccttct accaggtgca ccgaatcacg gggaaaactg tcaccaccac 1681 cagctatgag aagatagtgg gcaacaccaa agtcctggag atccccttgg agcccaaaaa 1741 caacatgagg gcaaccatcg actgtgcggg gatcttgaag cttagaaacg ccgacattga 1801 gctgcggaaa ggcgagacgg acattggaag aaagaacacg cgggtgagac tggttttccg 1861 agttcacatc ccagagtcca gtggcagaat cgtctcttta cagactgcat ctaaccccat 1921 cgagtgctcc cagcgatctg ctcacgagct gcccatggtt gaaagacaag acacagacag 1981 ctgcctggtc tatggcggcc agcaaatgat cctcacgggg cagaacttta catccgagtc 2041 caaagttgtg tttactgaga agaccacaga tggacagcaa atttgggaga tggaagccac 2101 ggtggataag gacaagagcc agcccaacat gctttttgtt gagatccctg aatatcggaa 2161 caagcatatc cgcacacctg taaaagtgaa cttctacgtc atcaatggga agagaaaacg 2221 aagtcagcct cagcacttta cctaccaccc agtcccagcc atcaagacgg agcccacgga 2281 tgaatatgac cccactctga tctgcagccc cacccatgga ggcctgggga gccagcctta 2341 ctacccccag cacccgatgg tggccgagtc cccctcctgc ctcgtggcca ccatggctcc 2401 ctgccagcag ttccgcacgg ggctctcatc ccctgacgcc cgctaccagc aacagaaccc 2461 agcggccgta ctctaccagc ggagcaagag cctgagcccc agcctgctgg gctatcagca 2521 gccggccctc atggccgccc cgctgtccct tgcggacgct caccgctctg tgctggtgca 2581 cgccggctcc cagggccaga gctcagccct gctccacccc tctccgacca accagcaggc 2641 ctcgcctgtg atccactact cacccaccaa ccagcagctg cgctgcggaa gccaccagga 2701 gttccagcac atcatgtact gcgagaattt cgcaccaggc accaccagac ctggcccgcc 2761 cccggtcagt caaggtcaga ggctgagccc gggttcctac cccacagtca ttcagcagca 2821 gaatgccacg agccaaagag ccgccaaaaa cggacccccg gtcagtgacc aaaaggaagt 2881 attacctgcg ggggtgacca ttaaacagga gcagaacttg gaccagacct acttggatga 2941 tgttaatgaa attatcagga aggagttttc aggacctcct gccagaaatc agacgtaa (2) INFORMATION FOR SEQ ID NO:2748: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: _base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2748 WO 00/09525 PCT/US99/17712 EPI-109 1023 1 gctgcagcac cctgggccac gccgatqact actgcaaact gtggcgccca cgacgagctc 61 gacttcaaac tcgtctttgg cgaggacggg gcgccggcgc cgccgccccc gggctcgcgg 121 cctgcagatc ttgagccaga tgattgtgca tccatttaca tctttaatgt agatccacct 181 ccatctactt taaccacacc actttgctta ccacatcatq gattaccgtc tcactcttct 241 gttttgtcac catcgtttca gctccaaagt cacaaaaact atgaaggaac ttgtgagatt 301 cctgaatcta aatatagccc attaggtggt cccaaaccct ttgagtgccc aagtattcaa 361 attacatcta tctctcctaa ctgtcatcaa gaattagatg cacatgaaga tgacctacag 421 ataaatgacc cagaacggga atttttggaa aggccttcta gagatcatct ctatcttcct 481 cttgagccat cctaccggga gtcttctctt agtcctagtc ctgccagcag catctcttct 541 aggagttggt tctctgatgc atcttcttgt gaatcgcttt cacatattta tgatgatgtg 601 gactcagagt tgaatgaagc tgcagcccga tttacccttg gatcccctct gacttctcct 661 ggtggctctc cagggggctg ccctggagaa gaaacttggc atcaacagta tggacttgga 721 cactcattat cacccaggca atctccttgc cactctccta gatccagtgt cactgatgag 781 aattggctga gccccaggcc agcctcagga ccctcatcaa ggcccacatc cccctgtggg 841 aaacggaggc actccagtgc tgaagtttgt tatgctgggt ccctttcacc ccatcactca 901 cctgttcctt cacctggtca ctcccccagg ggaagtgtga cagaagatac gtggctcaat 961 gcttctgtcc atggtgggtc aggccttggc cctgcagttt ttccatttca gtactgtgta 1021 gagactgaca tccctctcaa aacaaggaaa acttctgaag atcaagctgc catactacca 1081 ggaaaattag agctgtgttc agatgaccaa gggagtttat caccagcccg ggagacttca 1141 atagatgatg gccttggatc tcagtatcct ttaaagaaaq attcatgtgg tgatcagttt 1201 ctttcagttc cttcaccctt tacctggagc aaaccaaagc ctggccacac ccctatattt 1261 cgcacatctt cattacctcc actagactgg cctttaccag ctcattttgg acaatgtgaa. 1321 ctgaaaatag aagtgcaacc taaaactcat catcgagccc attatgaaac tgaaggtagc 1381 cgaggggcag taaaagcatc tactggggga catcctgttg tgaagctcct gggctataac 1441 gaaaagccaa taaatctaca aatgtttatt gggacagcag atgatcgata tttacgacct 1501 catgcatttt accaggtgca tcgaatcact gggaagacag tcgctactgc aagccaagag 1561 ataataattg ccagtacaaa agttctggaa attccacttc ttcctgaaaa taatatgtca. 1621 gccagtattg attgtgcagg tattttgaaa ctccgcaatt cagatataga acttcgaaaa 1681 ggagaaactg atattggcag aaagaatact agagtacgac ttgtgtttcg tgtacacatc 1741 ccacagccca gtggaaaagt cctttctctg cagatagcct ctatacccgt tgagtgctcc 1801 cagcggtctg ctcaagaact tcctcatatt gagaagtaca gtatcaacag ttgttctgta 1861 aatggaggtc atgaaatggt tgtgactgga tctaattttc ttccagaatc caaaatcatt 1921 tttcttgaaa aaggacaaga tggacgacct cagtgggagg tagaagggaa gataatcagg 1981 gaaaaatgtc aaggggctca cattgtcctt gaagttcctc catatcataa cccagcagtt 2041 acagctgcag tgcaggtgca cttttatctt tgcaatggca agaggaaaaa. aagccagtct 2101 caacgtttta cttatacacc agttttgctg aagcaagaac acagagaaga gattgatttg 2161 tcttcagttc catctttgcc tgtgcctcat cctgctcaga cccagaggcc ttcctctgat 2221 tcagggtgtt cacatqacag tgtactgtca ggacagagaa gtttgatttg ctccatccca 2281 caaacatatg catccatggt gacctcatcc catctgccac agttgcagtg tagagatgag 2341 agtgttagta aagaacagca tatgattcct tctccaattg tacaccagcc ttttcaagtc 2401 acaccaacac ctcctgtggg gtcttcctat cagcctatgc aaactaatgt tgtgtacaat 2461 ggaccaactt gtcttcctat taatgctgcc tctagtcaag aatttgattc agtttggttt 2521 cagcaggatg caactctttc tggtttagtg aatcttggct gtcaaccact gtcatccata 2581 ccatttcatt cttcaaattc aggctcaaca ggacatctct tagcccatac acctcattct 2641 gtgcataccc tgcctcatct gcaatcaatg ggatatcatt gttcaaatac aggacaaaga 2701 tctctttctt ctccagtggg tgaccagatt acaggtcagc cttcgtctca gttacaacct 2761 attacatatg gtccttcaca ttcagggtct gttacaacag cttccccagc agcttctcat 2821 cccttgggta. gttcaccgct ttctgggcca ccatctcctc agtttcagcc tatgccttac 2881 caatctccta gctcaggaac tggctcatca ccgtctccag ccaccagaat gcattctgga 2941 cagcactcaa ctcaagcaca aagtacgggc caggggggtc tttctgcacc ttcatcctta 3001 atatgtcaca gtttgtgtga tccagcgtca tttccacctg atggggcaac tgtgagcatt 3061 aaacctgaac cagaagatcg agagcctaac tttgcaacca ttggtctgca ggacatcact 3121 ttagatgatg accaatttat atctgacttg gaacaccagc catcaggttc agcagagaaa. 3181 tggcctaacc acagtgtgct ctcatgtcca gctcctttct ggagaatcta gaggtgaacg 3241 agataattgg gagagacatg tcccagattt ctgtttccca aggagcaggg gtgagcaggc 3301 aggctcccct cccgagtcct gagtccctgg atttaggaag atctgatggg ctctaacagt 3361 gcttactgca gccttgtgtc caccaccaac ttctcagcat gtttctctcc ttggaccttg 3421 ggtttccaac tcttcaacct tcaggtctgg ggccaggagt gggacccacc atttgtgggg 3481 aaagtagcat tcctccacct caggccttgg gtagatttgg caaaagaaca ggagcagcat 3541 aggctgtttg agctttgggg aaatgaactt tgctttttat atttaactag gatactttta 3601 aatgatgggt gctttgagtg tgaatccagc aggctctctt gtttccgagg tgctgctttt 3661 gcaggtgacc tggttactta actaggagtg gtgatttgta ctgctttatg gtcatttgaa 3721 gggcccttta gtttttatga taatttttaa aataggaact tttgataaga ccttctagaa 3781 gcaa (2) INFORMATION FOR SEQ ID NO:2749: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: _base pairs (B) TYPE: nucleic acid WO 00/09525 PCT/US99/17712 EPI-109 1024 (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2749 1 gctgcagcac cctgggccac gccgatgact actgcaaact gtggcgccca cgacgagctc 61 gacttcaaac tcgtctttgg cgaggacggg gcgccggcgc cgccgccccc gggctcgcgg 121 cctgcagatc ttgagccaga tgattgtgca tccatttaca tctttaatgt agatccacct 181 ccatctactt taaccacacc actttgctta ccacatcatg gattaccgtc tcactcttct 241 gttttgtcac catcgtttca gctccaaagt cacaaaaact atgaaggaac ttgtgagatt 301 cctgaatcta aatatagccc attaggtggt cccaaaccct ttgagtgccc aagtattcaa 361 attacatcta tctctcctaa ctgtcatcaa gaattagatg cacatgaaga tgacctacag 421 ataaatgacc cagaacggga atttttggaa aggccttcta gagatcatct ctatcttcct 481 cttgagccat cctaccggga gtcttctctt agtcctagtc ctgccagcag catctcttct 541 aggagttggt tctctgatgc atcttcttgt gaatcgcttt cacatattta tgatgatgtg 601 gactcagagt tgaatgaagc tgcagcccga tttacccttg gatcccctct gacttctcct 661 ggtggctctc cagggggctg ccctggagaa gaaacttggc atcaacagta tggacttgga 721 cactcattat cacccaggca atctccttgc cactctccta gatccagtgt cactgatgag 781 aattggctga gccccaggcc agcctcagga ccctcatcaa ggcccacatc cccctgtggg 841 aaacggaggc actccagtgc tgaagtttgt tatgctgggt ccctttcacc ccatcactca 901 cctgttcctt cacctggtca ctcccccagg ggaagtgtga cagaagatac gtggctcaat 961 gcttctgtcc atggtgggtc aggccttggc cctgcagttt ttccatttca gtactgtgta 1021 gagactgaca tccctctcaa aacaaggaaa acttctgaag atcaagctgc catactacca 1081 ggaaaattag agctgtgttc agatgaccaa gggagtttat caccagcccg ggagacttca 1141 atagatgatg gccttggatc tcagtatcct ttaaagaaag attcatgtgg tgatcagttt 1201 ctttcagttc cttcaccctt tacctggagc aaaccaaagc ctggccacac ccctatattt 1261 cgcacatctt cattacctcc actagactgg cctttaccag ctcattttgg acaatgtgaa 1321 ctgaaaatag aagtgcaacc taaaactcat catcgagccc attatgaaac tgaaggtagc 1381 cgaggggcag taaaagcatc tactggggga catcctgttg tgaagctcct gggctataac 1441 gaaaagccaa taaatctaca aatgtttatt gggacagcag atgatcgata tttacgacct 1501 catgcatttt accaggtgca tcgaatcact gggaagacag tcgctactgc aagccaagag 1561 ataataattg ccagtacaaa agttctggaa attccacttc ttcctgaaaa taatatgtca 1621 gccagtattg attgtgcagg tattttgaaa ctccgcaatt cagatataga acttcgaaaa 1681 ggagaaactg atattggcag aaagaatact agagtacgac ttgtgtttcg tgtacacatc 1741 ccacagccca gtggaaaagt cctttctctg cagatagcct ctatacccgt tgagtgctcc 1801 cagcggtctg ctcaagaact tcctcatatt gagaagtaca gtatcaacag ttgttctgta 1861 aatggaggtc atgaaatggt tgtgactgga tctaattttc ttccagaatc caaaatcatt 1921 tttcttgaaa aaggacaaga tggacgacct cagtgggagg tagaagggaa gataatcagg 1981 gaaaaatgtc aaggggctca cattgtcctt gaagttcctc catatcataa cccagcagtt 2041 acagctgcag tgcaggtgca cttttatctt tgcaatggca agaggaaaaa aagccagtct 2101 caacgtttta cttatacacc agttttgctg aagcaagaac acagagaaga gattgatttg 2161 tcttcagttc catctttgcc tgtgcctcat cctgctcaga cccagaggcc ttcctctgat 2221 tcagggtgtt cacatgacag tgtactgtca ggacagagaa gtttgatttg ctccatccca 2281 caaacatatg catccatggt gacctcatcc catctgccac agttgcagtg tagagatgag 2341 agtgttagta aagaacagca tatgattcct tctccaattg tacaccagcc ttttcaagtc 2401 acaccaacac ctcctgtggg gtcttcctat cagcctatgc aaactaatgt tgtgtacaat 2461 ggaccaactt gtcttcctat taatgctgcc tctagtcaag aatttgattc agtttggttt 2521 cagcaggatg caactctttc tggtttagtg aatcttggct gtcaaccact gtcatccata 2581 ccatttcatt cttcaaattc aggctcaaca ggacatctct tagcccatac acctcattct 2641 gtgcataccc tgcctcatct gcaatcaatg ggatatcatt gttcaaatac aggacaaaga 2701 tctctttctt ctccagtggg tgaccagatt acaggtcagc cttcgtctca gttacaacct 2761 attacatatg gtccttcaca ttcagggtct gttacaacag cttccccagc agcttctcat 2821 cccttgggta gttcaccgct ttctgggcca ccatctcctc agtttcagcc tatgccttac 2881 caatctccta gctcaggaac tggctcatca ccgtctccag ccaccagaat gcattctgga 2941 cagcactcaa ctcaagcaca aagtacgggc caggggggtc tttctgcacc ttcatcctta 3001 atatgtcaca gtttgtgtga tccagcgtca tttccacctg atggggcaac tgtgagcatt 3061 aaacctgaac cagaagatcg agagcctaac tttgcaacca ttggtctgca ggacatcact 3121 ttagatgatg atttgtttac cagtaataat tttgacttgc ttcagttgag acctacgttt 3181 tggccagtcc cagcaggaag atatctgagg aatctagagt gaacgagata attgggagag 3241 acatgtccca gatttctgtt tcccaaggag caggggtgag caggcaggct cccctcccga 3301 gtcctgagtc cctggattta ggaagatctg atgggctcta acagtgctta ctgcagcctt 3361 gtgtccacca ccaacttctc agcatgtttc tctccttgga ccttgggttt ccaactcttc 3421 aaccttcagg tctggggcca ggagtgggac ccaccattta tggggaaagt agcattcctc 3481 cacctcaggc cttgggtaga tttggcaaaa gaacaggagc agcataggct gtttgagctt 3541 tggggaaatg aactttgctt tttatattta actaggatac ttttaaatga tgggtgcttt 3601 gagtgtgaat ccagcaggct ctcttgtttc cgaggtgctg cttttgcagg tgacctggtt 3661 acttaactag gagtggtgat ttgtactgct ttatggtcat ttgaagggcc ctttagtttt 3721 tatgataatt tttaaaatag gaacttttga taagaccttc tagaagcaa (2) INFORMATION FOR SEQ ID NO:2750: (i) SEQUENCE CHARACTERISTICS: WO 00/09525 PCT/US99/17712 EPI-109 1025 (A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2750 1 gctgcagcac cctgggccac gccgatgact actgcaaact gtggcgccca cgacgagctc 61 gacttcaaac tcgtctttgg cgaggacggg gcgccggcgc cgccgccccc gggctcgcgg 121 cctgcagatc ttgagccaga tgattgtgca tccatttaca tctttaatgt agatccacct 181 ccatctactt taaccacacc actttgctta ccacatcatg gattaccgtc tcactcttct 241 gttttgtcac catcgtttca gctccaaagt cacaaaaact atgaaggaac ttgtgagatt 301 cctgaatcta aatatagccc attaggtggt cccaaaccct ttgagtgccc aagtattcaa 361 attacatcta tctctcctaa ctgtcatcaa gaattagatg cacatgaaga tgacctacag 421 ataaatgacc cagaacggga atttttggaa aggccttcta gagatcatct ctatcttcct 481 cttgagccat cctaccggga gtcttctctt agtcctagtc ctgccagcag catctcttct 541 aggagttggt tctctgatgc atcttcttgt gaatcgcttt cacatattta tgatqatgtg 601 gactcagagt tgaatgaagc tgcagcccga tttacccttg gatcccctct gacttctcct 661 ggtggctctc cagggggctg ccctggagaa gaaacttggc atcaacagta tggacttgga 721 cactcattat cacccaggca atctccttgc cactctccta gatccagtgt cactgatgag 781 aattggctga gccccaggcc agcctcagga ccctcatcaa ggcccacatc cccctgtggg 841 aaacggaggc actccagtgc tgaagtttgt tatgctgggt ccctttcacc ccatcactca 901 cctgttcctt cacctggtca ctcccccagg ggaagtgtga cagaagatac gtggctcaat 961 gcttctgtcc atggtgggtc aggccttggc cctgcagttt ttccatttca gtactgtgta 1021 gagactgaca tccctctcaa aacaaggaaa acttctgaag atcaagctgc catactacca 1081 ggaaaattag agctgtgttc agatgaccaa gggagtttat caccagcccg ggagacttca 1141 atagatgatg gccttggatc tcagtatcct ttaaagaaag atccatgtgg tgatcagttt 1201 ctttcagttc cttcaccctt tacctggagc aaaccaaagc ctggccacac ccctatattt 1261 cgcacatctt cattacctcc actagactgg cctttaccag ctcattttgg acaatgtgaa 1321 ctgaaaatag aagtgcaacc taaaactcat catcgagccc attatgaaac tgaaggtagc 1381 cgaggggcag taaaagcatc tactggggga catcctgttg tgaagctcct gggctataac 1441 gaaaagccaa taaatctaca aatgtttatt gggacagcag atgatcgata tttacgacct 1501 catgcatttt accaggtgca tcgaatcact gggaagacag tcgctactgc aagccaagag 1561 ataataattg ccagtacaaa agttctggaa attccacttc ttcctgaaaa taatatgtca 1621 gccagtattg attgtgcagg tattttgaaa ctccgcaatt cagatataga acttcgaaaa 1681 ggagaaactg atattggcag aaagaatact agagtacgac ttgtgtttcg tgtacacatc 1741 ccacagccca gtggaaaagt cctttctctg cagatagcct ctatacccgt tgagtgctcc 1801 cagcggtctg ctcaagaact tcctcatatt gagaagtaca gtatcaacag ttgttctgta 1861 aatggaggtc atgaaatggt tgtgactgga tctaattttc ttccagaatc caaaatcatt 1921 tttcttgaaa aaggacaaga tggacgacct cagtgggagg tagaagggaa gataatcagg 1981 gaaaaatgtc aaggggctca cattgtcctt gaagttcctc catatcataa cccagcagtt 2041 acagctgcag tgcaggtgca cttttatctt tgcaatggca agaggaaaae aagccagtct 2101 caacgtttta cttatacacc agttttgctg aagcaagaac acagagaaga gattgatttq 2161 tcttcagttc catctttgcc tgtgcctcat cctgctcaga cccagaggcc ttcctctgat 2221 tcagggtgtt cacatgacag tgtactgtca ggacagagaa gtttgatttg ctccatccca 2281 caaacatatg catccatggt gacctcatcc catctgccac agttgcagtg tagagatgag 2341 agtgttagta aagaacagca tatgattcct tctccaattg tacaccagcc ttttcaagtc 2401 acaccaacac ctcctgtggg gtcttcctat cagcctatgc aaactaatgt tgtgtacaat 2461 ggaccaactt gtcttcctat taatgctgcc tctagtcaag aatttgattc agtttggttt 2521 cagcaggatg caactctttc tggtttagtg aatcttggct gtcaaccact gtcatccata 2581 ccatttcatt cttcaaattc aggctcaaca ggacatctct tagcccatac acctcattct 2641 gtgcataccc tgcctcatct gcaatcaatg ggatatcatt gttcaaatac aggacaaaga 2701 tctctttctt ctccagtggg tgaccagatt acaggtcagc cttcgtctca gttacaacct 2761 attacatatg gtccttcaca ttcagggtct gttacaacag cttccccagc agcttctcat 2821 cccttgggta gttcaccgct ttctgggcca ccatctcctc agtttcagcc tatgccttac 2881 caatctccta gctcaggaac tggctcatca ccgtctccag ccaccagaat gcattctgga 2941 cagcactcaa ctcaagcaca aagtacgggc caggggggtc tttctgcacc ttcatcctta 3001 atatgtcaca gtttgtgtga tccagcgtca tttccacctg atggggcaac tgtgagcatt 3061 aaacctgaac cagaagatcg agagcctaac tttgcaacca ttggtctgca ggacatcact 3121 ttagatgatg gtaagttcat ctctgatatg ttcttgaagt agtgaagatt cagggacttt 3181 attctcccaa gtgtcatgaa aaagtttcta tggattgctt attggcatat ggttgggctt 3241 ttaaataagt tgttattaga aatatatgtt aatatataac tttgccaggt accacggctc 3301 acgcctgtat cccagcactt tggaaggctg aggcgggtgg atcacaaggt caggagttca 3361 agaccagcct ggccaacatg gtgtaacgct gtctctacta aaaatacaaa aaattagcca 3421 ggcatggtgg tgtgtgacta taatcccagc tactcgggag gctgagacag gagaatcact 3481 tgaacccggg aggtggcagt tgcagggagc taagatcgcg ccattgcact ccagcctggg 3541 cggcagagca agactccgtc tcgggaaaaa aaaaaaaaaa aaa (2) INFORMATION FOR SEQ ID NO:2751: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: base pairs WO 00/09525 PCT/US99/17712 EPI-109 1026 (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2751 1 gaattccggg ccgggagaac cgaacccctg gcggccgcga ccccggctcc cgccccggcc 61 ccggcccgac ccgccatgac ggggctggag gaccaggagt tcgacttcga gttcctcttc 121 gagtttaacc agcgcgacga gggcgccgcc gcggccgccc cagaacacta tggctatgca 181 tcctccaacg tcagccccgc cctgccgctc cccacggcgc actccaccct gccggccccg 241 tgccacaacc ttcagacctc cacaccgggc atcatcccgc cggcggatca cccctcgggg 301 tacggagcag ctttggacgg tgggcctgcg ggctacttcc tctcctccgg ccacaccagg 361 cctgatgggg cccctgccct ggagagtcct cgcatcgaga taacctcgtg cttgggcctg 421 taccacaaca ataaccagtt tttccacgat gtggaggtgg aagacgtcct ccctagctcc 481 aaacggtccc cctccacggc cacgctgagt ctgcccagcc tggaggccta cagagacccc 541 tcgtgcctga gcccggccag cagcctgtcc tcccggagct gcaactcaga ggcctcctcc 601 tacgagtcca actactcgta cccgtacgcg tccccccaga cgtcgccatg gcagtctccc 661 tgcgtgtctc ccaagaccac ggaccccgag gagggctttc cccgcgggct gggggcctgc 721 acactgctga gttccccgcg gcactccccc tccacctcgc cccgcgccag cgtcactgag 781 gagagctggc tgggtgcccg ctcctccaga cccgcgtccc cttgcaacaa gaggaagtac 841 agcctcaacg gccggcagcc gccctactca ccccaccact cgcccacgcc atccccgcac 901 ggctccccgc gggtcagcgt gaccgacgac tcgtggttgg gcaacaccac ccagtacacc 961 agctcggcca tcgtggccgc catcaacgcg ctgaccaccg acagcagcct ggacctggga 1021 gatggcgtcc ctgtcaagtc ccgcaagacc accctggagc agccgccctc agtggcgctc 1081 aaggtggagc ccgtcgggga ggacctgggc agccccccgc ccccggccga cttcgcgccc 1141 gaagactact cctctttcca gcacatcagg aagggcggct tctgcgacca gtacctggcg 1201 gtgccgcagc acccctacca gtgggcgaag cccaagcccc tgtcccctac gtcctacatg 1261 agcccgaccc tgcccgccct ggactggcag ctgccgtccc actcaggccc gtatgagctt 1321 cggattgagg tgcagcccaa gtcccaccac cgagcccact acgagacgga gggcagccgg 1381 ggggccgtga aggcgtcggc cggaggacac cccatcgtgc agctgcatgg ctacttggag 1441 aatgagccgc tgatgctgca gcttttcatt gggacggcgg acgaccgcct gctgcgcccg 1501 cacgccttct accaggtgca ccgcatcaca gggaagaccg tgtccaccac cagccacgag 1561 gccatcctct ccaacaccaa agtcctggag atcccactcc tgccggagaa cagcatgcga 1621 gccgtcattg actgtgccgg aatcctgaaa ctcagaaact ccgacattga acttcggaaa 1681 ggagagacgg acatcgggag gaagaacaca cgggtacggc tggtgttccg cgttcacgtc 1741 ccgcaaccca gcggccgcac gctgtccctg caggtggcct ccaaccccat cgaatgctcc 1801 cagcgctcag ctcaggagct gcctctggtg gagaagcaga gcacggacag ctatccggtc 1861 gtgggcggga agaagatggt cctgtctggc cacaacttcc tgcaggactc caaggtcatt 1921 ttcgtggaga aagccccaga tggccaccat gtctgggaga tggaagcgaa aactgaccgg 1981 gacctgtgca agccgaattc tctggtggtt gagatcccgc cgtttcggaa tcagaggata 2041 accagccccg ttcacgtcag tttctacgtc tgcaacggga agagaaagcg aagccagtac 2101 cagcgtttca cctaccttcc cgccaacgtt ccaattataa aaacagaacc cactgatgat 2161 tatgagcctg ctccaacctg tggaccggtg agccaggggt taagtcctct cccaagacca 2221 tactacagcc agcagctcgc gatgccaccc gaccccagct cctgcctcgt ggccggcttc 2281 ccgccctgtc cgcagagaag caccctgatg ccaqcggccc ctggcgtgag ccccaagctc 2341 cacgaccttt ctcccgctgc ctacaccaag ggcgttgcca gcccgggcca ctgtcacctc 2401 ggactcccgc agccggccgg agaggccccc gccgtccagg acgtgcccag gccagtggcc 2461 acgcaccccg gctcgcccgg gcagccaccc ccggccctgc tgccacagca gtaaatgaaa 2521 taatacgaaa tgacctctcc agcacgagca cccactccta gttgccacat tggagcactc 2581 agttcagcag gggtatgctg acttcagcag acaaagactt ttgaataaat aaactgaact 2641 cacacctggt accactcaga acctccaact gactgaatgc caggagctga acattaatat 2701 gtgcaaagat tggctctcca acaagaagga aagcagggag gaagggagac cactgtgtcg 2761 cctggaggag aagtcatctc atgacaacag aagggaggtg gccgggctga gcacggagac 2821 ccaccgtgca ggggcctttc atgggaacgg cccacacgca gtttgacccc acgcccagcc 2881 cttctggcac ccctggggtt caatactgga agtgccttat ttaaccagac catca (2) INFORMATION FOR SEQ ID NO:2752: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: _base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2752 1 agcaggaagc tcgcgccgcc gtcgccgccg ccgctcagct tccccgggcg cgtccaggac 61 ccgctgcgcc aggcgcgccg tccccggacc cggcgtgcgt ccctacgagg aaagggaccc 121 cgccgctcga gccgcctccg ccagccccac tgcgaggggt cccagagcca gccgcgcccg 181 ccctcgcccc cggccccgca gccttcccgc cctgcgcgcc atgaacgccc ccgagcggca 241 gccccaaccc gacggcgggg acgccccagg ccacgagcct gggggcagcc cccaagacga 301 gcttgacttc tccatcctct tcgactatga gtatttgaat ccgaacgaag aagagccgaa 361 tgcacataag gtcgccagcc caccctccgg acccgcatac cccgatgatg taatggacca 421 tggcctcaag ccatacagcc cccttgctag tctctcggc gagccccccg gccgattcgg WO 00/09525 PCT/US99/17712 EPI-109 1027 481 agagccggat agggtagggc cgcagaagtt tctgagcgcg gccaagccag caggggcctc 541 gggcctgagc cctcggatcg agatcactcc gtcccacgaa ctgatccagg cagtggggcc 601 cctccgcatg agagacgcgg gcctcctggt ggagcagcct cccctggccg gggtggccgc 661 cagcccgagg ttcaccctgc ccgtgcccgg cttcgagggc taccgcgagc cgctttgctt 721 gagccccgct agcagcggct cctctgccag cttcatttct gacaccttct ccccctacac 781 ctcgccctgc gtctcgccca ataacggcgg gcccgacgac ctgtgtccgc agtttcaaaa 841 catccctgct cattattccc ccagaacctc gccaataatg tcacctcgaa ccagcctcgc 901 cgaggacagc tgcctgggcc gccactcgcc cgtgccccgt ccggcctccc gctcctcatc 961 gcctggtgcc aagcggaggc attcgtgcgc cgaggccttg gttgccctgc cgcccggagc 1021 ctcaccccag cgctcccgga gcccctcgcc gcagccctca tctcacgtgg caccccagga 1081 ccacggctcc ccggctgggt acccccctgt ggctggctct gccgtgatca tggatgccct 1141 gaacagcctc gccacggact cgccttgtgg gatccccccc aagatgtgga agaccagccc 1201 tgacccctcg ccggtgtctg ccgccccatc caaggccggc ctgcctcgcc acatctaccc 1261 ggccgtggag ttcctggggc cctgcgagca gggcgagagg agaaactcgg ctccagaatc 1321 catcctgctg gttccgccca cttggcccaa gccgctggtg cctgccattc ccatctgcag 1381 catcccagtg actgcatccc tccctccact tgagtggccg ctgtccagtc agtcaggctc 1441 ttacgagctg cggatcgagg tgcaqcccaa gccacatcac cgggcccact atgagacaga 1501 aggcagccga ggggctgtca aagctccaac tggaggccac cctgtggttc agctccatgg 1561 ctacatggaa aacaagcctc tgggacttca gatcttcatt gggacagctg atgagcggat 1621 ccttaagccg cacgccttct accaggtgca ccgaatcacg gggaaaactg tcaccaccac 1681 cagctatgag aagatagtgg gcaacaccaa agtcctggag atccccttgg agcccaaaaa 1741 caacatgagg gcaaccatcg actgtgcggg gatcttgaag cttagaaacg ccgacattga 1801 gctgcggaaa ggcgagacgg acattggaag aaagaacacg cgggtgagac tggttttccg 1861 agttcacatc ccagagtcca gtggcagaat cgtctcttta cagactgcat ctaaccccat 1921 cgagtgctcc cagcgatctg ctcacgagct gcccatggtt gaaagacaag acacagacag 1981 ctgcctggtc tatggcggcc agcaaatgat cctcacgggg cagaacttta catccgagtc 2041 caaagttgtg tttactgaga agaccacaga tggacagcaa atttgggaga tggaagccac 2101 ggtggataag gacaagagcb agcccaacat gctttttgtt gagatccctg aatatcggaa 2161 caagcatatc cgcacacctg taaaagtgaa cttctacgtc atcaatggga agagaaaacg 2221 aagtcagcct cagcacttta cctaccaccc agtcccagcc atcaagacgg agcccacgga 2281 tgaatatgac cccactctga tctgcagccc cacccatgga ggcctgggga gccagcctta 2341 ctacccccag cacccgatgg tggccgagtc cccctcctgc ctcgtggcca ccatggctcc 2401 ctgccagcag ttccgcacgg ggctctcatc ccctgacgcc cgctaccagc aacagaaccc 2461 agcggccgta ctctaccagc ggagcaagag cctgagcccc agcctgctgg gctatcagca 2521 gccggccctc atggccgccc cgctgtccct tgcggacgct caccgctctg tgctggtgca 2581 cgccggctcc cagggccaga gctcagccct gctccacccc tctccgacca accagcaggc 2641 ctcgcctgtg atccactact cacccaccaa ccagcagctg cgctgcggaa gccaccagga 2701 gttccagcac atcatgtact gcgagaattt cgcaccaggc accaccagac ctggcccgcc 2761 cccggtcagt caaggtcaga ggctgagccc gggttcctac cccacagtca ttcagcagca 2821 gaatgccacg agccaaagag ccgccaaaaa cggacccccg gtcagtgacc aaaaggaagt 2881 attacctgcg ggggtgacca ttaaacagga gcagaacttg gaccagacct acttggatga 2941 tgttaatgaa attatcagga aggagttttc aggacctcct gccagaaatc agacgtaa 1 gctgcagcac cctgggccac gccgatgact actgcaaact gtggcgccca cgacgagctc 61 gacttcaaac tcgtctttgg cgaggacggg gcgccggcgc cgccgccccc gggctcgcgg 121 cctgcagatc ttgagccaga tgattgtgca tccatttaca tctttaatgt agatccacct 181 ccatctactt taaccacacc actttgctta ccacatcatg gattaccgtc tcactcttct 241 gttttgtcac catcgtttca gctccaaagt cacaaaaact atgaaggaac ttgtgagatt 301 cctgaatcta aatatagccc attaggtggt cccaaaccct ttgagtgccc aagtattcaa 361 attacatcta tctctcctaa ctgtcatcaa gaattagatg cacatgaaga tgacctacag 421 ataaatgacc cagaacggga atttttggaa aggccttcta gagatcatct ctatcttcct 481 cttgagccat cctaccggga gtcttctctt agtcctagtc ctgccagcag catctcttct 541 aggagttggt tctctgatgc atcttcttgt gaatcgcttt cacatattta tgatgatgtg 601 gactcagagt tgaatgaagic tgcagcccga tttacccttg gatcccctct gacttctcct 661 ggtggctctc cagggggctg ccctggagaa gaaacttggc atcaacagta tggacttgga 721 cactcattat cacccaggca atctccttgc cactctccta gatccagtgt cactgatgag 781 aattggctga gccccaggcc agcctcagga ccctcatcaa ggcccacatc cccctgtggg 841 aaacggaggc actccagtgc tgaagtttgt tatgctgggt ccctttcacc ccatcactca 901 cctgttcctt cacctggtca ctcccccagg ggaagtgtga cagaagatac gtggctcaat 961 gcttctgtcc atggtgggtc aggccttggc cctgcagttt ttccatttca gtactgtgta 1021 gagactgaca tccctctcaa aacaaggaaa acttctgaag atcaagctgc catactacca 1081 ggaaaattag agctgtgttc agatgaccaa gggagtttat caccagcccg ggagacttca 1141 atagatgatg gccttggatc tcagtatcct ttaaagaaag attcatgtgg tgatcagttt 1201 ctttcagttc cttcaccctt tacctggagc aaaccaaagc ctggccacac ccctatattt 1261 cgcacatctt cattacctcc actagactgg cctttaccag ctcattttgg acaatgtgaa 1321 ctgaaaatag aagtgcaacc taaaactcat catcgagccc attatgaaac tgaaggtagc 1381 cgaggggcag taaaagcatc tactggggga catcctgttg tgaagctcct gggctataac 1441 gaaaagccaa taaatctaca aatgtttatt gggacagcag atgatcgata tttacgacct 1501 catgcatttt accaggtgca tcgaatcact gggaagacag tcgctactgc aagccaagag WO 00/09525 PCTIUS99/17712 EPI-109 1028 1561 ataataattg ccagtacaaa agttctggaa attccacttc ttcctgaaaa taatatgtca 1621 gccagtattg attgtgcagg tattttgaaa ctccgcaatt cagatataga acttcgaaaa 1681 ggagaaactg atattggcag aaagaatact agagtacgac ttgtgtttcg tgtacacatc 1741 ccacagccca gtggaaaagt cctttctctg cagatagcct ctatacccgt tgagtgctcc 1801 cagcggtctg ctcaagaact tcctcatatt gagaagtaca gtatcaacag ttgttctgta 1861 aatggaggtc atgaaatggt tgtgactgga tctaattttc ttccagaatc caaaatcatt 1921 tttcttgaaa aaggacaaga tggacgacct cagtgggagg tagaagggaa gataatcagg 1981 gaaaaatgtc aaggggctca cattgtcctt gaagttcctc catatcataa cccagcagtt 2041 acagctgcag tgcaggtgca cttttatctt tgcaatggca agaggaaaaa aagccagtct 2101 caacgtttta cttatacacc agttttgctg aagcaagaac acagagaaga gattgatttg 2161 tcttcagttc catctttgcc tgtgcctcat cctgctcaga cccagaggcc ttcctctgat 2221 tcagggtgtt cacatgacag tgtactgtca ggacagagaa gtttgatttg ctccatccca 2281 caaacatatg catccatggt gacctcatcc catctgccac agttgcagtg tagagatgag 2341 agtgttagta aagaacagca tatgattcct tctccaattg tacaccagcc ttttcaagtc 2401 acaccaacac ctcctgtggg gtcttcctat cagcctatgc aaactaatgt tgtgtacaat 2461 ggaccaactt gtcttcctat taatgctgcc tctagtcaag aatttgattc agtttggttt 2521 cagcaggatg caactctttc tggtttagtg aatcttggct gtcaaccact gtcatccata 2581 ccatttcatt cttcaaattc aggctcaaca ggacatctct tagcccatac acctcattct 2641 gtgcataccc tgcctcatct gcaatcaatg ggatatcatt gttcaaatac aggacaaaga 2701 tctctttctt ctccagtggg tgaccagatt acaggtcagc cttcgtctca gttacaacct 2761 attacatatg gtccttcaca ttcagggtct gttacaacag cttccccagc agcttctcat 2821 cccttgggta gttcaccgct ttctgggcca ccatctcctc agtttcagcc tatgccttac 2881 caatctccta gctcaggaac tggctcatca ccgtctccag ccaccagaat gcattctgga 2941 cagcactcaa ctcaagcaca aagtacgggc caggggggtc tttctgcacc ttcatcctta 3001 atatgtcaca gtttgtgtga tccagcgtca tttccacctg atggggcaac tgtgagcatt 3061 aaacctgaac cagaagatcg agagcctaac tttgcaacca ttggtctgca ggacatcact 3121 ttagatgatg accaatttat atctgacttg gaacaccagc catcaggttc agcagagaaa 3181 tggcctaacc acagtgtgct ctcatgtcca gctcctttct ggagaatcta gaggtgaacg 3241 agataattgg gagagacatg tcccagattt ctgtttccca aggagcaggg gtgagcaggc 3301 aggctcccct cccgagtcct gagtccctgg atttaggaag atctgatggg ctctaacagt 3361 gcttactgca gccttgtgtc caccaccaac ttctcagcat gtttctctcc ttggaccttg 3421 ggtttccaac tcttcaacct tcaggtctgg ggccaggagt gggacccacc atttgtgggg 3481 aaagtagcat tcctccacct caggccttgg gtagatttgg caaaagaaca ggagcagcat 3541 aggctgtttg agctttgggg aaatgaactt tgctttttat atttaactag gatactttta 3601 aatgatgggt gctttgagtg tgaatccagc aggctctctt gtttccgagg tgctgctttt 3661 gcaggtgacc tggttactta actaggagtg gtgatttgta ctgctttatg gtcatttgaa 3721 gggcccttta gtttttatga taatttttaa aataggaact tttgataaga ccttctagaa 3781 gcaa 1 gctgcagcac cctgggccac gccgatgact actgcaaact gtggcgccca cgacgagctc 61 gacttcaaac tcgtctttgg cgaggacggg gcgccggcgc cgccgccccc gggctcgcgg 121 cctgcagatc ttgagccaga tgattgtgca tccatttaca tctttaatgt agatccacct 181 ccatctactt taaccacacc actttgctta ccacatcatg gattaccgtc tcactcttct 241 gttttgtcac catcgtttca gctccaaagt cacaaaaact atgaaggaac ttgtgagatt 301 cctgaatcta aatatagccc attaggtggt cccaaaccct ttgagtgccc aagtattcaa 361 attacatcta tctctcctaa ctgtcatcaa gaattagatg cacatgaaga tgacctacag 421 ataaatgacc cagaacggga atttttggaa aggccttcta gagatcatct ctatcttcct 481 cttgagccat cctaccggga gtcttctctt agtcctagtc ctgccagcag catctcttct 541 aggagttggt tctctgatgc atcttcttgt gaatcgcttt cacatattta tgatgatgtg 601 gactcagagt tgaatgaagc tgcagcccga tttacccttg gatcccctct gacttctcct 661 ggtggctctc cagggggctg ccctggagaa gaaacttggc atcaacagta tggacttgga 721 cactcattat cacccaggca atctccttgc cactctccta gatccagtgt cactgatgag 781 aattggctga gccccaggcc agccteagga ccctcatcaa ggcccacatc cccctgtggg 841 aaacggaggc actccagtgc tgaagtttgt tatgctgggt ccctttcacc ccatcactca 901 cctgttcctt cacctggtca ctcccccagg ggaagtgtga cagaagatac gtggctcaat 961 gcttctgtcc atggtgggtc aggccttggc cctgcagttt ttccatttca gtactgtgta 1021 gagactgaca tccctctcaa aacaaggaaa acttctgaag atcaagctgc catactacca 1081 ggaaaattag agctgtgttc agatgaccaa gggagtttat caccagcccg ggagacttca 1141 atagatgatg gccttggatc tcagtatcct ttaaagaaag attcatgtgg tgatcagttt 1201 ctttcagttc cttcaccctt tacctggagc aaaccaaagc ctggccacac ccctatattt 1261 cgcacatctt cattacctc c actagactgg cctttaccag ctcattttgg acaatgtgaa 1321 ctgaaaatag aagtgcaacc taaaactcat catcgagccc attatgaaac tgaaggtagc 1381 cgaggggcag taaaagcatc tactggggga catcctgttg tgaagctcct gggctataac 1441 gaaaagccaa taaatctaca aatgtttatt gggacagcag atgatcgata tttacgacct 1501 catgcatttt accaggtgca tcgaatcact gggaagacag tcgctactgc aagccaagag 1561 ataataattg ccagtacaaa agttctggaa attccacttc ttcctgaaaa taatatgtca 1621 gccagtattg attgtgcagg tattttgaaa ctccgcaatt cagatataga acttcgaaaa 1681 ggagaaactg atattggcag aaagaatact agagtacgac ttgtgtttcg tgtacacatc 1741 ccacagccca gtggaaaagt cctttctctg cagatagcct ctatacccgt tgagtgctcc WO 00/09525 PCTIUS99/17712 EPI-109 1029 1801 cagcggtctg ctcaagaact tcctcatatt gagaagtaca gtatcaacag ttgttctgta 1861 aatggaggtc atgaaatggt tgtgactgga tctaattttc ttccagaatc caaaatcatt 1921 tttcttgaaa aaggacaaga tggacgacct cagtgggagg tagaagggaa gataatcagg 1981 gaaaaatgtc aaggggctca cattgtcctt gaagttcctc catatcataa cccagcagtt 2041 acagctgcag tgcaggtgca cttttatctt tgcaatggca agaggaaaaa aagccagtct 2101 caacgtttta cttatacacc agttttgctg aagcaagaac acagagaaga gattgatttg 2161 tcttcagttc catctttgcc tgtgcctcat cctgctcaga cccagaggcc ttcctctgat 2221 tcagggtgtt cacatgacag tgtactgtca ggacagagaa gtttgatttg ctccatccca 2281 caaacatatg catccatggt gacctcatcc catctgccac agttgcagtg tagagatgag 2341 agtgttagta aagaacagca tatgattcct tctccaattg tacaccagcc ttttcaagtc 2401 acaccaacac ctcctgtggg gtcttcctat cagcctatgc aaactaatgt tgtgtacaat 2461 ggaccaactt gtcttcctat taatgctgcc tctagtcaag aatttgattc agtttggttt 2521 cagcaggatg caactctttc tggtttagtg aatcttggct gtcaaccact gtcatccata 2581 ccatttcatt cttcaaattc aggctcaaca ggacatctct tagcccatac acctcattct 2641 gtgcataccc tgcctcatct gcaatcaatg ggatatcatt gttcaaatac aggacaaaga 2701 tctctttctt ctccagtggg tgaccagatt acaggtcagc cttcgtctca gttacaacct 2761 attacatatg gtccttcaca ttcagggtct gttacaacag cttccccagc agcttctcat 2821 cccttgggta gttcaccgct ttctgggcca ccatctcctc agtttcagcc tatgccttac 2881 caatctccta gctcaggaac tggctcatca ccgtctccag ccaccagaat gcattctgga 2941 cagcactcaa ctcaagcaca aagtacgggc caggggggtc tttctgcacc ttcatcctta 3001 atatgtcaca gtttgtgtga tccagcgtca tttccacctg atggggcaac tgtgagcatt 3061 aaacctgaac cagaagatcg agagcctaac tttgcaacca ttqgtctgca ggacatcact 3121 ttagatgatg atttgtttac cagtaataat tttgacttgc ttcagttgag acctacgttt 3181 tggccagtcc cagcaggaag atatctgagg aatctagagt gaacgagata attgggagag 3241 acatgtccca gatttctgtt tcccaaggag caggggtgag caggcaggct cccctcccga 3301 gtcctgagtc cctggattta ggaagatctg atgggctcta acagtgctta ctgcagcctt 3361 gtgtccacca ccaacttctc agcatgtttc tctccttgga ccttgggttt ccaactcttc 3421 aaccttcagg tctggggcca ggagtgggac ccaccatttg tggggaaagt agcattcctc 3481 cacctcaggc cttgggtaga tttggcaaaa gaacaggagc agcataggct gtttgagctt 3541 tggggaaatg aactttgctt tttatattta actaggatac ttttaaatga tgggtgcttt 3601 gagtgtgaat ccagcaggct ctcttgtttc cgaggtgctg cttttgcagg tgacctggtt 3661 acttaactag gagtggtgat ttgtactgct ttatggtcat ttgaagggcc ctttagtttt 3721 tatgataatt tttaaaatag gaacttttga taagaccttc tagaagcaa 1gctgcagcac cctgggccac gccgatgact actgcaaact gtggcgccca cgacgagctc 61 gacttcaaac tcgtctttgg cgaggacggg gcgccggcgc cgccgccccc gggctcgcgg 121 cctgcagatc ttgagccaga tgattgtgca tccatttaca tctttaatgt agatccacct 181 ccatctactt taaccacacc actttgctta ccacatcatg gattaccgtc tcactcttct 241 gttttgtcac catcgtttca gctccaaagt cacaaaaact atgaaggaac ttgtgagatt 301 cctgaatcta aatatagccc attaggtggt cccaaaccct ttgagtgccc aagtattcaa 361 attacatcta tctctcctaa ctgtcatcaa gaattagatg cacatgaaga tgacctacag 421 ataaatgacc cagaacggga atttttggaa aggccttcta gagatcatct ctatcttcct 481 cttgagccat cctaccggga gtcttctctt agtcctagtc ctgccagcag catctcttct 541 aggagttggt tctctgatgc atcttcttgt gaatcgcttt cacatattta tgatgatgtg 601 gactcagagt tgaatgaagc tgcagcccga tttacccttg gatcccctct gacttctcct 661 ggtggctctc cagggggctg ccctggagaa gaaacttggc atcaacagta tggacttgga 721 cactcattat cacccaggca atctccttgc cactctccta gatccagtgt cactgatgag 781 aattggctga gccccaggcc agcctcagga ccctcatcaa ggcccacatc cccctgtggg 841 aaacggaggc actccagtgc tgaagtttgt tatgctgggt ccctttcacc ccatcactca 901 cctgttcctt cacctggtca ctcccccagg ggaagtgtga cagaagatac gtggctcaat 961 gcttctgtcc atggtgggtc aggccttggc cctgcagttt ttccatttca gtactgtgta 1021 gagactgaca tccctctcaa aacaaggaaa acttctgaag atcaagctgc catactacca 1081 ggaaaattag agctgtgttc agatgaccaa gggagtttat caccagcccg ggagacttca 1141 atagatgatg gccttggatc tcagtatcct ttaaagaaag attcatgtgg tgatcagttt 1201 ctttcagttc cttcaccctt tacctggagc aaaccaaagc ctggccacac ccctatattt 1261 cgcacatctt cattacctcc actagactgg cctttaccag ctcattttgg acaatgtgaa 1321 ctgaaaatag aagtgcaacc taaaactcat catcgagccc attatgaaac tgaaggtagc 1381 cgaggggcag taaaagcatc tactggggga catcctgttg tgaagctcct gggctataac 1441 gaaaagccaa taaatctaca aatgtttatt gggacagcag atgatcgata tttacgacct 1501 catgcatttt accaggtgca tcgaatcact gggaagacag tcgctactgc aagccaagag 1561 ataataattg ccagtacaaa agttctggaa attccacttc ttcctgaaaa taatatgtca 1621 gccagtattg attgtgcagg tattttgaaa ctccgcaatt cagatataga acttcgaaaa 1681 ggagaaactg atattggcag aaagaatact agagtacgac ttgtgtttcg tgtacacatc 1741 ccacagccca gtggaaaagt cctttctctg cagatagcct ctatacccgt tgagtgctcc 1801 cagcggtctg ctcaagaact tcctcatatt gagaagtaca gtatcaacag ttgttctgta 1861 aatggaggtc atgaaatggt tgtgactgga tctaattttc ttccagaatc caaaatcatt 1921 tttcttgaaa aaggacaaga tggacgacct cagtgggagg tagaagggaa gataatcagg 1981 gaaaaatgtc aaggggctca cattgtcctt gaagttcctc catatcataa cccagcagtt 2041 acagctgcag tgcaggtgca cttttatctt tgcaatggca agaggaaaaa aagccagtct WO 00/09525 PCT/US99/17712 EPI-109 1030 2101 caacgtttta cttatacacc agttttgctg aagcaagaac acagagaaga gattgatttg 2161 tcttcagttc catctttgcc tgtgcctcat cctgctcaga cccagaggcc ttcctctgat 2221 tcagggtgtt cacatgacag tgtactgtca ggacagagaa gtttgatttg ctccatccca 2281 caaacatatg catccatggt gacctcatcc catctgccac agttgcagtg tagagatgag 2341 agtgttagta aagaacagca tatgattcct tctccaattg tacaccagcc ttttcaagtc 2401 acaccaacac ctcctgtggg gtcttcctat cagcctatgc aaactaatgt tgtgtacaat 2461 ggaccaactt gtcttcctat taatgctgcc tctagtcaag aatttgattc agtttggttt 2521 cagcaggatg caactctttc tggtttagtg aatcttgqct gtcaaccact gtcatccata 2581 ccatttcatt cttcaaattc aggctcaaca ggacatctct tagcccatac acctcattct 2641 gtgcataccc tgcctcatct gcaatcaatg ggatatcatt gttcaaatac aggacaaaga 2701 tctctttctt ctccagtggg tgaccagatt acaggtcagc cttcgtctca gttacaacct 2761 attacatatg gtccttcaca ttcagggtct gttacaacag cttccccagc agcttctcat 2821 cccttgggta gttcaccgct ttctgggcca ccatctcctc agtttcagcc tatgccttac 2881 caatctccta gctcaggaac tggctcatca ccgtctccag ccaccagaat gcattctgga 2941 cagcactcaa ctcaagcaca aagtacgggc caggggggtc tttctgcacc ttcatcctta 3001 atatgtcaca gtttgtgtga tccagcgtca tttccacctg atggggcaac tgtgagcatt 3061 aaacctgaac cagaagatcg agagcctaac tttgcaacca ttggtctgca ggacatcact 3121 ttagatgatg gtaagttcat ctctgatatg ttcttgaagt agtgaagatt cagggacttt 3181 attctcccaa gtgtcatgaa aaagtttcta tggattgctt attggcatat ggttgggctt 3241 ttaaataagt tgttattaga aatatatgtt aatatataac tttgccaggt accacggctc 3301 acgcctgtat cccagcactt tggaaggctg aggcgggtgg atcacaaggt caggagttca 3361 agaccagcct ggccaacatg gtgtaacgct gtctctacta aaaatacaaa aaattagcca 3421 ggcatggtgg tgtgtgacta taatcccagc tactcgggag gctgagacag gagaatcact 3481 tgaacccggg aggtggcagt tgcagggagc taagatcgcg ccattgcact ccagcctggg 3541 cggcagagca agactccgtt tcgggaaaaa aaaaaaaaaa aaa 1 gaattccggg ccgggagaac cgaacccctg gcggccgcga ccccggctcc cgccccggcc 61 ccggcccgac ccgccatgac ggggctggag gaccaggagt tcgacttcga gttcctcttc 121 gagtttaacc agcgcgacga gggcgccgcc gcggccgccc cagaacacta tggctatgca 181 tcctccaacg tcagccccgc cctgccgctc cccacggcgc actccaccct gccggccccg 241 tgccacaacc ttcagacctc cacaccgggc atcatcccgc cggcggatca cccctcgggg 301 tacggagcag ctttggacgg tgggcctgcg ggctacttcc tctcctccgg ccacaccagg 361 cctgatgggg cccctgccct ggagagtcct cgcatcgaga taacctcgtg cttgggcctg 421 taccacaaca ataaccagtt tttccacgat gtggaggtgg aagacgtcct ccctagctcc 481 aaacggtccc cctccacggc cacgctgagt ctgcccagcc tggaggccta cagagaccec 541 tcgtgcctga gcccggccag cagcctgtcc tcccggagct gcaactcaga ggcctcctcc 601 tacgagtcca actactcgta cccgtacgcg tccccccaga cgtcgccatg gcagtctccc 661 tgcgtgtctc ccaagaccac ggaccccgag gagggctttc cccgcgggct gggggcctgc 721 acactgctga gttccccgcg gcactccccc tccacctcgc cccgcgccag cgtcactgag 781 gagagctggc tgggtgcccg ctcctccaga cccgcgtccc cttgcaacaa gaggaagtac 841 agcctcaacg gccggcagcc gccctactca ccccaccact cgcccacgcc atccccgcac 901 ggctccccgc gggtcagcgt gaccgacgac tcgtggttgg gcaacaccac ccagtacacc 961 agctcggcca tcgtggccgc catcaacgcg ctgaccaccg acagcagcct ggacctggga 1021 gatggcgtcc ctgtcaagtc ccgcaagacc accctggagc agccgccctc agtggcgctc 1081 aaggtggagc ccgtcgggga ggacctgggc agccccccgc ccccggccga cttcgcgccc 1141 gaagactact cctctttcca gcacatcagg aagggcggct tctgcgacca gtacctggcg 1201 gtgccgcagc acccctacca gtgggcgaag cccaagcccc tgtcccctac gtcctacatg 1261 agcccgaccc tgcccgccct ggactggcag ctgccgtccc actcaggccc gtatgagctt 1321 cggattgagg tgcagcccaa gtcccaccac cgagcccact acgagacgga gggcagccgg 1381 ggggccgtga aggcgtcggc cggaggacac cccatcgtgc agctgcatgg ctacttggag 1441 aatgagccgc tgatgctgc -a gcttttcatt gggacggcgg acgaccgcct gctgcgcccg 1501 cacgccttct accaggtgca ccgcatcaca gggaagaccg tgtccaccac cagccacgag 1561 gccatcctct ccaacaccaa agtcctggag atcccactcc tgccggagaa cagcatgcga 1621 gccgtcattg actgtgccgg aatcctgaaa ctcagaaact ccgacattga acttcggaaa 1681 ggagagacgg acatcgggag gaagaacaca cgggtacggc tggtgttccg cgttcacgtc 1741 ccgcaaccca gcggccgcac gctgtccctg caggtggcct ccaaccccat cgaatgctcc 1801 cagcgctcag ctcaggagct gcctctggtg gagaagcaga gcacggacag ctatccggtc 1861 gtgggcggga agaagatggt cctgtctggc cacaacttcc tgcaggactc caaggtcatt 1921 ttcgtggaga aagccccaga tggccaccat gtctgggaga tggaagcgaa aactgaccgg 1981 gacctgtgca agccgaattc tctggtggtt gagatcccgc cgtttcggaa tcagaggata 2041 accagccccg ttcacgtcag tttctacgtc tgcaacggga agagaaagcg aagccagtac 2101 cagcgtttca cctaccttcc cgccaacgtt ccaattataa aaacagaacc cactgatgat 2161 tatgagcctg ctccaacctg tggaccggtg agccaggggt taagtcctct cccaagacca 2221 tactacagcc agcagctcgc gatgccaccc gaccccagct cctgcctcgt ggccggcttc 2281 ccgccctgtc cgcagagaag caccctgatg ccagcggccc ctggcgtgag ccccaagctc 2341 cacgaccttt ctcccgctgc ctacaccaag ggcgttgcca gcccgggcca ctgtcacctc 2401 ggactcccgc agccggccgg agaggccccc gccgtccagg acgtgcccag gccagtggcc 2461 acgcaccccg gctcgcccgg gcagccaccc ccggccctgc tgccacauca gtaaatgaaa 2521 taatacgaaa tgacctctcc agcacgagca cccactccta gttgccacat tggagcactc WO 00/09525 PCT/US99/17712 EPI-109 1031 2581 agttcagcag gggtatgctg acttcagcag acaaagactt ttgaataaat aaactgaact 2641 cacacctggt accactcaga acctccaact gactgaatgc caggagctga acattaatat 2701 gtgcaaagat tggctctcca acaagaagga aagcagggag gaagggagac cactgtgtcg 2761 cctggaggag aagtcatctc atgacaacag aagggaggtg gccgggctga gcacggagac 2821 ccaccgtgca ggggcctttc atgggaacgg cccacacgca gtttgacccc acgcccagcc 2881 cttctggcac ccctggggtt caatactgga agtgccttat ttaaccagac catca (2) INFORMATION FOR SEQ ID NO:2753: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2753 1 gaattcccaa ggcgcccccg accgcctgct acgcgggggc cgcgccggcg ccctcgcagg 61 tcaagagcaa ggccaagaag accgtggaca agcacagcga cgagtacaag atccggcgcg 121 agcgcaacaa catcgccgtg cgcaagagcc gcgacaaggc caagatgcgc aacctggaga 181 cgcagcacaa ggtcctggag ctcacggccg agaacgagcg gctgcagaag aaggtggagc 241 agctgtcgcg cgagggaatt c (2) INFORMATION FOR SEQ ID NO:2754: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2754 1 gtccttcgcg tcccggcggc gcggcggagg ggccggcgtg acgcagcggt tgctacgggc 61 cgcccttata aataaccggg ctcaggagaa actttagcga gtcagagccg cgcacgggac 121 tgggaagggg acccacccga gggtccagcc accagccccc tcactaatag cggccacccc 181 ggcagcggcg gcagcagcag cagcgacgca gcggcgacag ctcagagcag ggaggccgcg 241 cacctgcggg ccggccggag cgggcagccc caggccccct ccccgggcac ccgcgttcat 301 gcaacgcctg gtggcctggg acccagcatg tctccccctg ccgccgccgc cgcctgcctt 361 taaatccatg gaagtggcca acttctacta cgaggcggac tgcttggctg ctgcgtacgg 421 cggcaaggcg gcccccgcgg cgccccccgc ggccagaccc gggccgcgcc cccccgccgg 481 cgagctgggc agcatcggcg accacgagcg cgccatcgac ttcagcccgt acctggagcc 541 gctgggcgcg ccgcaggccc cggcgcccgc cacggccacg gacaccttcg aggcggctcc 601 gcccgcgccc gcccccgcgc ccgcctcctc cgggcagcac cacgacttcc tctccgacct 661 cttctccgac gactacgggg gcaagaactg caagaagccg gccgagtacg gctacgtgag 721 cctggggcgc ctgggggctg ccaagggcgc gctgcacccc ggctgcttcg cgcccctgca 781 cccaccgccc ccgccgccgc cgccgcccgc cgagctcaag gcggagccgg gcttcgagcc 841 cgcggactgc aagcggaagg aggaggccgg ggcgccgggc ggcggcgcag gcatggcggc 901 gggcttcccg tacgcgctgc gcgcttacct cggctaccag gcggtgccga gcggcagcag 961 cgggagcctc tccacgtcct cctcgtccag cccgcccggc acgccgagcc ccgctgacgc 1021 caaggccccc ccgaccgcct gctacgcggg ggccgggccg gcgccctcgc aggtcaagag 1081 caaggccaag aagaccgtgg acaagcacag cgacgagtac aagatccggc gcgagcgcaa 1141 caacatcgcc gtgcgcaaga gccgcgacaa ggccaagatg cgcaacctgg agacgcagca 1201 caaggtcctg gagctcacgg ccgagaacga gcggctgcag aagaaggtgg agcagctgtc 1261 gcgcgagctc agcaccctgc ggaacttgtt caagcagctg cccgagcccc tgctcgcctc 1321 ctccggccac tgctagcgcg gcccccgcgg cgtccccctg gggccggccg gggctgagac 1381 tccggggagc gcccgcgccc gcgccctcgc ccccnccccc nnnnccgcaa aactttggca 1441 ctggggcact tggcagcngg ggagcccgtc ggtaatttta atattttatt atatatatat 1501 atctatattt tgccaaccaa ccgtacatgc agatggctcc cgcccgtggt gtataaagaa 1561 gaaatgtcta tgtgtacaga tgaatgataa actctctgct ctccctctgc ccctctccag 1621 gcccggcggg cggggccggt ttcgaagttg atgcaatcgg tttaaacatg gctgaacgcg 1681 tgtgtacacg ggactgacgc aacccacgtg taactgtcag ccgggccctg agtaatcgct 1741 taaagatgtt ctagggcttg ttgctgttga tgttttgttt tgttttgttt tttggtcttt 1801 ttttgtatta taaaaaataa tctatttcta tgagaaaaga ggcgtctgta tattttggga 1861 atcttttccg tttcaagcaa ttaagaacac ttttaataaa cttttttttg (2) INFORMATION FOR SEQ ID NO:2755: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2755 1 gaattcccaa ggcgcccccg accgcctgctc acgcgggggc cgcgccggcg ccctcgcagg 61 tcaagagcaa ggccaagaag accgtggaca agcacagcga cgagtacaag atccggcgcg 121 agcgcaacaa catcgccgtg cgcaagagcc gcgacaaggc caagatgcgc aacctggaga WO 00/09525 PCTUS99/17712 EPI-109 1032 181 cgcagcacaa ggtcctggag ctcacggccg agaacgagcg gctgcagaag aaggtggagc 241 agctgtcgcg cgagggaatt C 1 gtccttcgcg tcccggcggc gcggcggagg ggccggcgtg acgcagcggt tgctacgggc 61 cgcccttata aataaccggg ctcaggagaa actttagcga gtcagagccg cgcacgggac 121 tgggaagggg acccacccga gggtccagcc accagccccc tcactaatag cggccacccc 181 ggcagcggcg gcagcagcag cagcgacgca gcggcgacag ctcagagcag ggaggccgcg 241 cacctgcggg ccggccggag cgggcagccc caggccccct ccccgggcac ccgcgttcat 301 gcaacgcctg gtggcctggg acccagcatg tctccccctg ccgccgccgc cgcctgcctt 361 taaatccatg gaagtggcca acttctacta cgaggcggac tgcttggctg ctgcgtacgg 421 cggcaaggcg gcccccgcgg cgccccccgc ggccagaccc gggccgcgcc cccccgccgg 481 cgagctgggc agcatcggcg accacgagcg cgccatcgac ttcagcccgt acctggagcc 541 gctgggcgcg ccgcaggccc cggcgcccgc cacggccacg gacaccttcg aggcggctcc 601 gcccgcgccc gcccccgcgc ccgcctcctc cgggcagcac cacgacttcc tctccgacct 661 cttctccgac gactacgggg gcaagaactg caagaagccg gccgagtacg gctacgtgag 721 cctggggcgc ctgggggctg ccaagggcgc gctgcacccc ggctgcttcg cgcccctgca 781 cccaccgccc ccgccgccgc cgccgcccgc cgagctcaag gcggagccgg gcttcgagcc 841 cgcggactgc aagcggaagg aggaggccgg ggcgccgggc ggcggcgcag gcatggcggc 901 gggcttcccg tacgcgctgc gcgcttacct cggctaccag gcggtgccga gcggcagcag 961 cgggagcctc tccacgtcct cctcgtccag cccgcccggc acgccgagcc ccgctgacgc 1021 caaggccccc ccgaccgcct gctacgcggg ggccgggccg gcgccctcgc aggtcaagag 1081 caaggccaag aagaccgtgg acaagcacag cgacgagtac aagatccggc gcgagcgcaa 1141 caacatcgcc gtgcgcaaga gccgcgacaa ggccaagatg cgcaacctgg agacgcagca 1201 caaggtcctg gagctcacgg ccgagaacga gcggctgcag aagaaggtgg agcagctgtc 1261 gcgcgagctc agcaccctgc ggaacttgtt caagcagctg cccgagcccc tgctcgcctc 1321 ctccggccac tgctagcgcg gcccccgcgg cgtccccctg gggccggccg gggctgagac 1381 tccggggagc gcccgcgccc gcgccctcgc ccccnccccc nnnnccgcaa aactttggca 1441 ctggggcact tggcagcngg ggagcccgtc ggtaatttta atattttatt atatatatat 1501 atctatattt tgccaaccaa ccgtacatgc agatggctcc cgcccgtggt gtataaagaa 1561 gaaatgtcta tgtgtacaga tgaatgataa actctctgct ctccctctgc ccctctccag 1621 gcccggcggg cggggccggt ttcgaagttg atgcaatcgg tttaaacatg gctgaacgcg 1681 tgtgtacacg ggactgacgc aacccacgtg taactgtcag ccgggccctg agtaatcgct 1741 taaagatgtt ctagggcttg ttgctgttga tgttttgttt tgttttgttt tttggtcttt 1801 ttttgtatta taaaaaataa tctatttcta tgagaaaaga ggcgtctgca tattttggga 1861 atcttttccg tttcaagcaa ttaagaacac ttttaataaa cttttttttg (2) INFORMATION FOR SEQ ID NO:2756: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: _base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2756 1 gaccagagca atttctgctt ttcacagggc gggtttctca acggtgactt gtgggcagtg 61 ccttctgctg agcgagtcat ggcccgaagg cagaactaac tgtgcctgca gtcttcactc 121 tcaggatgca gccgaggtgg gcccaagggg ccacgatgtq gcttggagtc ctgctgaccc 181 ttctgctctg ttcaagcctt gagggtcaag aaaactcttt cacaatcaac agtgttgaca 241 tgaagagcct gccggactgg acggtgcaaa atgggaagaa cctgaccctg cagtgcttcg 301 cggatgtcag caccacctct cacgtcaagc ctcagcacca gatgctgttc tataaggatg 361 acgtgctgtt ttacaacatc tcctccatga agagcacaga gagttatttt attcctgaag 421 tccggatcta tgactcaggg acatataaat gtactgtgat tgtgaacaac aaagagaaaa 481 ccactgcaga gtaccaggtg ttggtggaag gagtgcccag tcccagggtg acactggaca 541 agaaagaggc catccaaggt gggatcgtga gggtcaactg ttctgtccca gaggaaaagg 601 ccccaataca cttcacaatt gaaaaacttg aactaaatga aaaaatggtc aagctgaaaa 661 gagagaagaa ttctcgagac cagaattttg tgatactgga attccccgtt gaggaacagg 721 accgcgtttt atccttccga tgtcaagcta ggatcatttc tgggatccat atgcagacct 781 cagaatctac caagagtgaa ctggtcaccg tgacggaatc cttctctaca cccaagttcc 841 acatcagccc caccggaatg atcatggaag gagctcagct ccacattaag tgcaccattc 901 aagtgactca cctggcccag gagtttccag aaatcataat tcagaaggac aaggcgattg 961 tggcccacaa cagacatggc aacaaggctg tgtactcagt catggccatg gtggagcaca 1021 gtggcaacta cacgtgcaaa gtggagtcca gccgcatatc caaggtcagc agcatcgtgg 1081 tcaacataac agaactattt tccaagcccg aactggaatc ttccttcaca catctggacc 1141 aaggtgaaag actgaacctg tcctgctcca tcccaggagc acctccagcc aacttcacca 1201 tccagaagga agatacgatt gtgtcacaga ctcaagattt caccaagata gcctcaaagt 1261 cggacagtgg gacgtatatc tgcactgcag gtattgacaa agtggtcaag aaaagcaaca 1321 cagtccagat agtcgtatgt gaaatgctct cccagcccag gatttcttat gatgcccagt 1381 ttgaggtcat aaaaggacag accatcgaag tccgttgcga atcgatcagt ggaactttgc 1441 ctatttctta ccaactttta aaaacaagta aagttttgga gaatagtacc aagaactcaa 1501 atgatcctgc ggtattcaaa gacaacccca ctgaagacgt cgaataccag tgtgttgcag 1561 ataattgcca ttcccacgcc aaaatgttaa gtgaggttct gagggtgaag gtgatagccc WO 00/09525 PCT/US99/17712 EPI-109 1033 1621 cggtggatga ggtccaaatz tctatcctgt caagtaaggt ggtggagtct ggagaggaca 1681 ttgtgctgca atgtgctgtz aatgaaggat ctggtcccat cacctataag ttttacagag 1741 aaaaagaggg caaaccctrz tatcaaatga cctcaaatgc cacccaggca ttttggacca 1801 agcagaaggc taacaaggaa caggagggag agtattactg cacagccttc aacagagcca 1861 accacgcctc cagtgtcccc agaagcaaaa tactgacagt cagagtcatt cttgccccat 1921 ggaagaaagg acttattaca gtggttatca tcggagtgat cattgctctc ttgatcattg 1981 cggccaaatg ttattttczg aggaaagcca aggccaagca gatgccagtg gaaatgtcca 2041 ggccagcagt accacttctg aactccaaca acgagaaaat gtcagatccc aatatggaag 2101 ctaacagtca ttacggtcac aatgacgatg tcggaaacca tgcaatgaaa ccaataaatg 2161 ataataaaga gcctctgaac tcagacgtgc agtacacgga agttcaagtg tcctcagctg 2221 agtctcacaa agatctagga aagaaggaca cagagacagt gtacagtgaa gtccggaaag 2281 ctgtccctga tgccgtggaa agcagatact ctagaacgga aggctccctt gatggaactt 2341 agacagcaag gccagatgca catccctgga aggacatcca tgttccgaga agaacagatg 2401 atccctgtat ttcaagacct ctgtcc (2) INFORMATION FOR SEQ ID NO:2757: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2757 1 gaattccggg agaagtgacc agagcaattt ctgcttttca cagggcgggt ttctcaacgg 61 tgacttgtgg gcagtgcctt ctgctgagcg agtcatggcc cgaaggcaga actaactgtg 121 cctgcagtct tcactctcag gatgcagccg aggtgggccc aaggggccac gatgtggctt 181 ggagtcctgc tgacccttc gctctgttca agccttgagg gtcaagaaaa ctctttcaca 241 atcaacagtg ttgacatgaa gagcctgccg gactggacgg tgcaaaatgg gaagaacctg 301 accctgcagt gcttcgcgga tgtcagcacc acctctcacg tcaagcctca gcaccagatg 361 ctgttctata aggatgacgt gctgttttac aacatctcct ccatgaagag cacagagagt 421 tattttattc ctgaagtccg gatctatgac tcagggacat ataaatgtac tgtgattgtg 481 aacaacaaag agaaaaccac tgcagagtac cagctgttgg tggaaggagt gcccagtccc 541 agggtgacac tggacaagaa agaggccatc caaggtggga tcgtgagggt caactgttct 601 gtcccagagg aaaaggcccc aatacacttc acaattgaaa aacttgaact aaatgaaaaa 661 atggtcaagc tgaaaagaga gaagaattct cgagaccaga attttgtgat actggaattc 721 cccgttgagg aacaggaccg cgttttatcc ttccgatgtc aagctaggat catttctggg 781 atccatatgc agacctcaga atctaccaag agtgaactgg tcaccgtgac ggaatccttc 841 tctacaccca agttccacat cagccccacc ggaatgatca tggaaggagc tcagctccac 901 attaagtgca ccattcaagt gactcacctg gcccaggagt ttccagaaat cataattcag 961 aaggacaagg cgattgtggc ccacaacaga catggcaaca aggctgtgta ctcagtcatg 1021 gccatggtgg agcacagtgg caactacacg tgcaaagtgg agtccagccg catatccaag 1081 gtcagcagca tcgtggtcaa cataacagaa ctattttcca agcccgaact ggaatcttcc 1141 ttcacacatc tggaccaagg tgaaagactg aacctgtcct gctccatccc aggagcacct 1201 ccagccaact tcaccatcca gaaggaagat acgattgtgt cacagactca agatttcacc 1261 aagatagcct caaagtcgga cagtgggacg tatatctgca ctgcaggtat tgacaaagtg 1321 gtcaagaaaa gcaacacagt ccagatagtc gtatgtgaaa tgctctccca gcccaggatt 1381 tcttatgatg cccagtttga ggtcataaaa ggacagacca tcgaagtccg ttgcgaatcg 1441 atcagtggaa ctttgcctat ttcttaccaa cttttaaaaa caagtaaagt tttggagaat 1501 agtaccaaga actcaaatga tcctgcggta ttcaaagaca accccactga agacgtcgaa 1561 taccagtgtg ttgcagataa ttgccattcc catgccaaaa tgttaagtga ggttctgagg 1621 gtgaaggtga tagccccggt ggatgaggtc cagatttcta tcctgtcaag taaggtggtg 1681 gagtctggag aggacattgt gctgcaatgt gctgtgaatg aaggatctgg tcccatcacc 1741 tataagtttt acagagaaaa agagggcaaa cccttctatc aaatgacctc aaatgccacc 1801 caggcatttt ggaccaagca gaaggctagc aaggaacagg agggagagta ttactgcaca 1861 gccttcaaca gagccaacca cgcctccagt gtccccagaa gcaaaatact gacagtcaga 1921 gtcattcttg ccccatggaa gaaaggactt attgcagtgg ttatcatcgg agtgatcatt 1981 gctctcttga tcattgcggc caaatgttat tttctgagga aagccaaggc caagcagatg 2041 ccagtggaaa tgtccaggcc agcagtacca cttctgaact ccaacaacga gaaaatgtca 2101 gatcccaata tggaagctaa cagtcattac ggtcacaatg acgatgtcag aaaccatgca 2161 atgaaaccaa taaatgataa taaagagcct ctgaactcag acgtgcagta cacggaagtt 2221 caagtgtcct cagctgagtc tcacaaagat ctaggaaaga aggacacaga gacagtgtac 2281 agtgaagtcc ggaaagctgt ccctgatgcc gtggaaagca gatactctag aacggaaggc 2341 tcccttgatg gaacttagac agcaaggcca gatgcacatc cctggaagga catccatgtt 2401 ccgagaagaa cagataatcc ctgtatttca agacctctgt gcacttattt atgaacctgc 2461 cctgctccca cagaacacag caattcctca ggctaagctg ccggttctta aatccatcct 2521 gctaagttaa tgttgggtag aaagagatac agagggg (2) INFORMATION FOR SEQ ID NO:2758: (1) SEQUENCE CHARACTERISTICS: (A) LENGTH: base pairs WO 00/09525 PCT/US99/17712 EPI-109 1034 (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2758 1 cccgggttca agcgattctc ctgcctcagc ctcttgggta gctgggatta taggcgtgtg 61 ccaccgtgcc tggctaattt ttgtattttt attggagaca gggtttcacc atgttggcca 121 ggctggtctg aaactcctga cctcaggcaa tcctcctacc tcagcctctc aaagtgctgg 181 gattaccggc atgagccacg actcccggcc ccaaaggtca atcttaaagc tacaaggtat 241 cttttaaaag gagtaggaat aacgtatttt gaggcttaaa ggagtaggaa tagtgtattt 301 ttagatttga agccatcttc taaagggtac gatatttggt taacatgtca ctccttatcg 361 ccatggaaga agttaattct attctttttt tttttttttt gagatggagt ctcactctgt 421 tgcccaggct ggagtacaat ggtgtgatct cagctcactg caacctctgc ctcctgggtt 481 caagcaattc tcctgcctca gcctcctgag tagcagggat tacaggggtt ctccaccatg 541 cctgtctaat ttttgtattt ttttttttag tagaggtgga gtttcaccat gttggtcagg 601 ctggtctcaa acccctaacc tcatgatccg cccgccttgg cctcccaaag tgctgggatt 661 acaggcgtga gccaccatgc ccagccgtta attctattct tactgcttac tcccttattt 721 tgtatgttct tcttctatct tacatctttt gcttttgcta ttgcttaagc tagcctacgc 781 caagggtgct ctttgccccc tacttcctct gctattctcg cctcagttcc gctgcattcc 841 aagctcagcc tgccccagca gcaggtctct ttgacaaacc tgcaattttg gggaaaagtc 901 agccccaaga aaggcagggg gcccagactt atgctgtgtg gcaaaagccc tctttgatgg 961 gggaagggga ggactggaaa agcagagaga tctttctgga tgtcctggga gagcagccct 1021 ttgggtggtg ggtggaggct ggaggcaggg aggaatcccc tcacagtgcc atgagaaggg 1081 cccccaaacc caggcgagac agagggaggg tcaagaacgc caaggcaaat gtcacttgtg 1141 ccttgttttt tccctaaaga aactaaacaa agcggccgcg ttcggtggcc cctcaggaag 1201 gccggtcatt tcctgaggag atatcaggcc agcccaggcc ccattgttcc cggtttccag 1261 ccatggctgc cattacctga ccagcgccac agccggtctc tctgcaggcg ccgggagaag 1321 tgaccagagc aatttctgct tttcacaggg cgggtttctc aacggtgact tgtgggcagt 1381 gccttctgct gagcgagtca tggcccgaag gcagaactaa ctgtgcctgc agtcttcact 1441 ctcaggatgc agccgaggtg ggcccaaggg gccacgatgt ggcttggagt cctgctgacc 1501 cttctgctct gtgagtgttt actctgtttc cacatcactt taactccatg agcatcgaag (2) INFORMATION FOR SEQ ID NO:2759: (i) SEQUENCE CHARlACTERISTICS: (A) LENGTH: _base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2759 1 gaattccggg agaagtgacc agagcaattt ctgcttttca cagggcgggt ttctcaacgg 61 tgacttqtgg gcagtgcctt ctgctgagcg agtcatggcc cgaaggcaga actaactgtg 121 cctgcagtct tcactctcag gatgcagccg aggtgggccc aaggggccac gatgtggctt 181 ggagtcctgc tgacccttct gctctgttca agccttgagg gtcaagaaaa ctctttcaca 241 atcaacagtg ttgacatgaa gagcctgccg gactggacgg tgcaaaatgg gaagaacctg 301 accctgcagt gcttcgcgga tgtcagcacc acctctcacg tcaagcctca gcaccagatg 361 ctgttctata aggatgacgt gctgttttac aacatctcct ccatgaagag cacagagagt 421 tattttattc ctgaagtccg gatctatgac tcagggacat ataaatgtac tgtgattgtg 481 aacaacaaag agaaaaccac tgcagagtac cagctgttgg tggaaggagt gcccagtccc 541 agggtgacac tggacaagaa agaggccatc caaggtggga tcgtgagggt caactgttct 601 gtcccagagg aaaaggcccc aatacacttc acaattgaaa aacttgaact aaatgaaaaa 661 atggtcaagc tgaaaagaga gaagaattct cgagaccaga attttgtgat actggaattc 721 cccgttgagg aacaggaccg cgttttatcc ttccgatgtc aagctaggat catttctggg 781 atccatatgc agacctcaga atctaccaag agtgaactgg tcaccgtgac ggaatccttc 841 tctacaccca agttccacat cagccccacc ggaatgatca tggaaggagc tcagctccac 901 attaagtgca ccattcaagt gactcacctg gcccaggagt ttccagaaat cataattcag 961 aaggacaagg cgattgtggc ccacaacaga catggcaaca aggctgtgta ctcagtcatg 1021 gccatggtgg agcacagtgg caactacacg tgcaaagtgg agtccagccg catatccaag 1081 gtcagcagca tcgtggtcaa cataacagaa ctattttcca agcccgaact ggaatcttcc 1141 ttcacacatc tqgaccaagg tgaaagactg aacctgtcct gctccatccc aggagcacct 1201 ccagccaact tcaccatcca gaaggaagat acgattgtgt cacagactca agatttcacc 1261 aagatagcct caaagtcgga cagtgggacg tatatctgca ctgcaggtat tgacaaagtg 1321 gtcaagaaaa gcaacacagt ccagatagtc gtatgtgaaa tgctctccca gcccaggatt 1381 tcttatgatg cccagtttga ggtcataaaa ggacagacca tcgaagtccg ttgcgaatcg 1441 atcagtggaa ctttgcctat ttcttaccaa cttttaaaaa caagtaaagt tttggagaat 1501 agtaccaaga actcaaatga tcctgcggta tcaaagaca accccactga agacgtcgaa 1561 taccagtgtg ttgcagataa ttgccattcc catgccaaaa tgttaagtga ggttctgagg 1621 gtgaaggtga tagccccggt ggatgaggtc cagatttcta tcctgtcaag taaggtggtg 1681 gagtctggag aggacattgt gctgcaatgt gctgtgaatg aaggatctgg tcccatcacc 1741 tataagtttt acagagaaaa agagggcaaa cccttctatc aaatgacctc aaatgccacc 1801 caggcatttt ggaccaagca gaaggctagc aaggaacagg agggagagta ttactgcaca WO 00/09525 PCT/US99/17712 EPI-109 1035 1861 gccttcaaca gagccaacca cgcctccagt gtccccagaa gcaaaatact gacagtcaga 1921 gtcattcttg ccccatggaa gaaaggactt attgcagtgg ttatcatcgg agtgatcatt 1981 gctctcttga tcattgcggc caaatgttat tttctgagga aagccaaggc caagcagatg 2041 ccagtggaaa tgtccaggcc agcagtacca cttctgaact ccaacaacga gaaaatgtca 2101 gatcccaata tggaagctaa cagtcattac ggtcacaatg acgatgtcag aaaccatgca 2161 atgaaaccaa taaatgataa taaagagcct ctgaactcag acgtgcagta cacggaagtt 2221 caagtgtcct cagctgagtc tcacaaagat ctaggaaaga aggacacaga gacagtgtac 2281 agtgaagtcc ggaaagctgt ccctgatgcc gtggaaagca gatactctag aacggaaggc 2341 tcccttgatg gaacttagac agcaaggcca gatgcacatc cctggaagga catccatgtt 2401 ccgagaagaa cagataatcc ctgtatttca agacctctgt gcacttattt atgaacctgc 2461 cctgctccca cagaacacag caattcctca ggctaagctg ccggttctta aatccatcct 2521 gctaagttaa tgttgggtag aaagagatac agagggg (2) INFORMATION FOR SEQ ID NO:2760: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2760 1 tcttttggtt ttgctattgc ttaagctagc ctacgccaag ggtgctcttt gccccctact 61 tcctctgcta ttctcgcctc agttccgctg cattccaagc tcagcctgcc ccagcagcag 121 gtctctttga caaacctgca attttgggga aaagtcagcc caagaaaggc agggggccca 181 gacttatgct gtgtggcaaa agccctcttt gatggggcaa gggtaggact ggaaaagcag 241 agagatcttt ctggatgtcc tgggagagca gccctttggg tggtgggtgg aggctggagg 301 cagggaggaa tcccctcaca gtgagaaggg cccccaaacc caggcgagac agagggaggg 361 tcaagaacgc caaggcaaat gtcacttgtg ccttgttttt tccctaaaga aactaaacaa 421 agcggccgcg ttcggtggcc cctcaggaag gccggtcatt tcctgaggag atatcaggcc 481 agcccaggcc ccattgttcc cggtttccag ccatggctgc cattacctga ccagcgccac 541 agccggtctc tctgcaggcg ccgggagaag tgaccagagc aatttctgct tttcacaggg 601 cgggtttctc aacggtgact tgtgggcagt gccttctgct gagcgagtca tggcccgaag 661 gcagaactaa ctgtgcctgc agtcttcact ctcaggatgc agccgaggtg ggcccaaggg 721 gccacgatgt ggcttggagt cctgctgacc cttctgctct gtgagtgttt actctgtttc 781 cacatcactt taactccatg agcatcgaag cttctggaat caacatgttt cttatgtttc 841 ttgcaggttc aagccttgag ggtcaagaaa actgtaagtc tgatgtttcc actgtaacag 901 atgtttctac ctggcttcct cctttctctt ctgtgatgcc taaaacgcac attaaattgc 961 tggggtttga tacttctaac aattaaggaa aagaatccaa ttgagaacta aagtttatcc 1021 catgtgggca tttttagaaa ggcttagatc taagccaagt tctggtcagt gtgttttaga 1081 agtagcacac gtttccttgg ctggtctgaa agtagtgggt tatcttgatg aattgtttag 1141 tcagttacag atcaaactcc atgttctttt ctctgttctc acgactactc ttgactagtc 1201 taaaaatata ttaggttgtt gaaaagtaat tgtggttttt gccattactt tttaaaagat 1261 ggcaaaaaac acaattataa gtagcacaca ttttcttttt tttttccttt tttttttgag 1321 acagagtctc tgttacccag gctggagtgc agtggtgcaa tccggctctc tgcaaactcc 1381 gcctccaggg ttcaagggat tctcctgtct cagcctcctg ggtcgctgga attagagg (2) INFORMATION FOR SEQ ID NO:2761: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: _base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (0) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2761 1 ttggcaggct ggtctcaaac tcctgacctc aggtgatccg ctggcctcca cctcccaaag 61 tgctgggatt acaggtgtga gccaccacgc ccggcctcac attttctaga tttcagtgca 121 ttgctgtttt ttgggatggg gaagtgattt ttttatttta atgagcaatt ccataattag 181 ttttttgttg ttttaccata atggcttatt tgaatattgt aaggtatccc caactgtttt 241 tatttgcaaa tgagatataa ttgatttgtt aqacatatga agacagatcc tagtttaaat 301 tgttgctact ttttttactc ctaaatgata aaaatcacac actcgagctc (2) INFORMATION FOR SEQ ID NO:2762: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2762 1 ttggcaggct ggtctcaaac tcctgacctc aggtgatccg ctggcctcca cctcccaaag 61 tgctgggatt acaggtgtga gccaccacgc ccggcctcac attttctaga tttcagtgca 121 ttgctgtttt ttgggatggg gaagtgattt ttttatttta atgagcaatt ccataattag 181 ttttttgttg ttttaccata atggcttatt tgaatattgt aaggtatccc caactgtttt 241 tatttgcaaa tgagatataa ttgatttgtt agacatatga agacagatcc tagtttaaat WO 00/09525 PCT/US99/17712 EPI-109 1036 301 tgttgctact ttttttaczc ctaaatgata aaaatcacac actcgagctc (2) INFORMATION FOR SEQ ID NO:2763: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2763 1 gctgtcccac agcccaccct tcatcacaat agtcctgaaa ctttttgggt tcagtaagga 61 aatctgtggg ccttctctcc agaaaaagca cacatttgca cacaattgga ggtagttgat 121 gagcctccta acacccaccc atgcacctcc caggggctgt gtcccccagg ttgtgaacag 181 tcactctgtg taaatagtga gacctacagg cagtaattca gtttggctgt gcttggctgg 241 tttatttaga aagatgataa tgttt (2) INFORMATION FOR SEQ ID NO:2764: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2764 1 gagctctcca agggcagaca ctgccagcct cactgttctc tgaaccccca gtatgggaca 61 gtgcttggca cagaaaaacc cccttaaatg tttgctatga atggtgctaa ggaagaaggc 121 agagaatgtc aaccagaggc caggcactgg caatatatac acggcccc (2) INFORMATION FOR SEQ ID NO:2765: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2765 1 ataccttggc tcactgcaac ctctgcctcc caggttcaag cagttctcct gcctcagtct 61 cccaagtagc tgggattaca ggcgcccacc accacacccg gctaattttg tatttttagt 121 agagatgagg tttcaccatg ttggccaggc tggtcttgaa ctcctgacct caagtgatcc 181 acccgcctcg gcctcccaaa gtgctgggat tacaggcata aaccaccgtg cccggctggt 241 cca (2) INFORMATION FOR SEQ ID NO:2766: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2766 1 gagctcatcc agcaggcttc ttaaatcagg agcttgtaag ttgcatataa agacaaaaaa 61 gggagttcca aagagtaatg ctgtgggaaa tgacttgaat ttaaaccgtc accttgtttg 121 atctcatgga ctggtcagac accatttttg ttgtcgttgt tgttgttaaa ttaattgctc 181 agaatatagc agcaggcgca aattgtagta ctcgttttaa aattgaagat taaattttaa 241 attacccaac aaaggcctaa ctttgttaaa ag (2) INFORMATION FOR SEQ ID NO:2767: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2767 1 gaattctacc gacagcctat ggttactgga tataagccaa ttctgttctg gggacttgcc 61 agaaatgaca caattggcca gttgacccac agcctagttc ctagcagaga ttggatagct 121 gattgagcgt tgtggctgtt ttgaggcttg accagagatt cctgccgttg gcagagggga 181 atctgtagtc tttgcttctt ggtagcaggt gaggctgaaa acgcaagtag caggctaaaa 241 actggtttca agtcctcacc atctggtgaa acctcagagc ccatcagata gaaaatgcca 301 gctgggactg tgctaattcg gtaaggcctg ggtggagaag gagggcctgg gcacgaccat 361 ctggtttcgg aatggaggta gcagtcattt attaagtact taatgtatat cgggcactgt 421 acaggagacg ttctggctgt tctcctgtac atttcctgca aagacctaat gagatatgat 481 tactccatcc tacaggtaag gaaactgagc tcagagagtc tagctgccca gggtcacaca 541 gtaaatgatg agccaggact tgaacacttg actgcttgaa tcctgtactc cctccagggg WO 00/09525 PCTIUS99/17712 EPI-109 1037 601 ccaagatgtg gcagctcaca gaatgcctat atctttttt ttttttgtct tttgagacag 661 tctcactctg tcgcccaggc tggagtgcag tggtgagatc tcacctcact gcaacccccg 721 cctcccaggt tcaagtgatt cttgtgcctc agcctctcaa gtagctgggt tacaggcctg 781 caccaccaaa cctggctaat ttttgtattt ttagtagaga gggggtttca ccatgttggc 841 caggccagtc tctaactgct gacctcaggt gatccaccca ccttggtctc ccaaagtgct 901 gggattatag gcgtgagcca ccatacctag ctctacatct ttatcactct gttcctttgc 961 cttggtggga aaagttgcag cttagtacca actgcctcct gcttgagcca ctgtgcacag 1021 ttactatcag cctggccctg taggcacgta gaacccctgg actcaatact gcataggatg 1081 ggataagacc acatctgatg tggtgaaggt caccgggatg atgttgtttc tgagataaca 1141 ggtatgtctg ccttccttcg ggttgcattt agctttcaca atcaacagtg ttgacatgaa 1201 gagcctgccg gactggacgg tgcaaaatgg gaagaacctg accctgcagt gcttcgcgga 1261 tgtcagcacc acctctcacg tcaagcctca gcaccagatg ctgttctata aggatgacgt 1321 gctgttttac aacatctcct ccatgaagag cacagagagt tattttattc ctgaagtccg 1381 gatctatgac tcagggacat ataaatgtac tgtgattgtg aacaacaaag agaaaaccac 1441 tgcagagtac cagctgttgg tggaaggtga gtccttggaa ctgagcacag gcaagcagat 1501 ggagcatagc acacagtggc gtgaataaca gctgtgaatg aatagtgaca ctggacttaa 1561 ctctccaccc atcaccctct cattcatctg cctggcattt tccttacctg aatacgtaag 1621 cactagacat attccccaat aggcaggccc ttccttcctt ccttccttcc ttccttcctt 1681 ccttccttcc ttccttcctt ccttccttcc ttcctttctt tctttgatgg agtctcactc 1741 tgtcacccag tctggagtgc agtgggtgat ctcggctcac tgcaacctct gcctcccagg 1801 ttcaagcgat tctcctgcct cagcctccca agtaattggg attacaggtg tgtgccacca 1861 cacctggcta attttgtatt tttagtagag atggggtttc actgtgttgg tcaggctggt 1921 ctcgaactct gacctcaagt gatccacctg cctcccaaaa tgcttcttca tctcgctcta 1981 taaattacaa tttctttctt caagactcaa ctcaatgatg ttttgccaaa acaaaatggg 2041 tctaccccag ggtgccagtc agtacagctc tgatgctctc tctacaggca atggtatttg 2101 tgtgtataaa ggccacagcg gtgtgttaag acacctcgtt ctgcagtcac tctgcctggg 2161 tttcaatctt gggtcaagtc cttaacatgc tctaaacttc aaaatcctca ccagtaaaag 2221 gaagataaca acgataccca tttcaggcaa ttattgagag ggttaaaagt gtcatgtggg 2281 tagagtgctt agcaaaattt ccagcaccta gtgagttcct aataaataga aatgtattta 2341 tttatttgag acagagtctt cctctgtcac ccaggctaaa gagcaatggc gcgaccttgg 2401 ctcactgcaa cctctgtctc ctgggttcaa gcgattctcc tgtctcagcc tcccaagaaa 2461 ctgggattac aggcacgcgc cactgtgcct ggctaatttt ttgtattttt agtaaggatg 2521 gggttttacc atgttggcca gcctggtctc gaactcctaa cttcaagtga tttacccacc 2581 ttggcctccc agagtgtcag gattacaggt gtgagccacc atgcccggtc cacaaatatt 2641 ctatttcact cagtattggc atccgttctt acacatctgt ctgctcttct ggatagtgaa 2701 attgtaaaga cagagatggt gtttgggttt attcttatat cttgaacaat gaatctggct 2761 catagtaggc attcagtcaa tgttcatgga ataaattaaa gtcagtccta gcctgtgggt 2821 gcattcaata aagggtaaca acaatcacag tgacactgac aaatactggg ttacctttcc 2881 cctctaagca tcatctgttg ggaatctgat tqtgtcctct tcccaatagg attataaacc 2941 attgaaaaca ccaagtacat cttgaccata ttttattttt taaatttatt tatttattta 3001 tttatttatt tttagacaga gtctcactct gttgcccagg ctggagggca gtggcacgat 3061 ctcagctcac tgcaacctct gccttcgggg ttcaagcaat tctcctgcct cagcctccaa 3121 gtagctggga ttacaggtgc ctgccaccat gccggctaat tttgatttaa tagagatggg 3181 gttcgccatg ttggccaggc tggtctcaaa ctcctgacct caggtgatcc acctgcctca 3241 gcctcccaaa gtgttgagat tacagatgtg agccacctcg cgtggcctta gtggtgattt 3301 tggtggaccc atcacccgag cagtgtacac tgtacccagt gtgtagtcat tttatccctc 3361 gctccctccc actctttccc ctgagtcccc aaagtccact gtatcattct tatgcctttg 3421 tttcctcata gcttagctcc cattgagcat attttatatt ttttcctttc ttttcttctc 3481 ttttttgaga cagggtctct gttgcccagg ctggagtgca gtggtgggat tactgctcac 3541 tgccgcctca acctcctagg ctcaagtgat tctcccacct cggcctccca agtagctggg 3601 actaccagtg cacaccacta actacccctg gctaatttta attttttttt ttgtagagat 3661 agcatttcac cgtgttgccc aggctggtct ccaactcctg ggctcaagag atccacccac 3721 ctcagcctcc agattttata tatttcaaag tgcctagtac tgtgctgggc acatacctgt 3781 tcatttatta cctggtaggt cgcactgggt gttcagagaa caaaaaagag ccctctcatg 3841 ggatcaacta cagtcactca gcggagggga gggcttgtgt ctctcaatca ggctgatact 3901 gacagacttt cttcttcaat caggctgata ctgacatgac tttctacttt ccccgtagga 3961 gtgcccagtc ccagggtgac actggacaag aaagaggcca tccaaggtgg gatcgtgagg 4021 gtcaactgtt ctgtcccaga ggaaaaggcc ccaatacact tcacaattga aaaacttgaa 4081 ctaaatgaaa aaatggtcaa gctgaaaaga gagaagaatt ctcgagacca gaattttgtg 4141 atactggaat tccccgttga ggaacaggac cgcgttttat ccttccgatg tcaagctagg 4201 atcatttctg ggatccatat gcagacctca gaatctacca agagtgaact ggtcaccgtg 4261 acgggtcagc atctgctccc ttcctcatcg ttctttgtgg tttctggt (2) INFORMATION FOR SEQ ID NO:2768: Wi SEQUENCE CHARACTERISTICS: (A) LENGTH: _base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2768 1 gttctagaga agaaaggttg aattttaaag ttagttagga acaatagaaa agtttgaaaa 61 ggggaagcag caaaaagagc agaagaggct cctcttgccc aggtttgcac ctgagtccaa 121 ccaggttgtc ttcctctctt gcagaatcct tctctacacc caagttccac atcagcccca 181 ccggaatgat catggaagga gctcagctcc acattaagtg caccattcaa gtgactcacc WO 00/09525 PCT/US99/17712 EPI-109 1038 241 tggcccagga gtttccagaa atcataattc agaaggacaa ggcgattgtg gcccacaaca 301 gacatggcaa caaggctgtg tactcagtca tggccatggt ggagcacagt ggcaactaca 361 cgtgcaaagt ggagtccagc cgcatatcca aggtcagcag catcgtggtc aacataacag 421 gtagggctgc tgctgccgga gggtgttggc atatggcggg ctcaagaggc caccatgctg 481 caatccagca tggccaaaga gagctgatca tttcctgccc ctgcttatct gaatgaatgt 541 gctcagatgg ggctttggtg ctcgtgggag gaaaccactg cagagcgagt taacagtcta 601 ctgtgcgtgt tgagggtaca ggctccggca ccaaagctta accctgccgc tcactgcttc 661 tgtgaccttg ggtgagttat tgaacgtgcc gcagcgctgt gagatggtga taatgacctt 721 ttaggactgc tataatgatt aatgagataa ctatactgta agcatgagct gagagatttg 781 tacagagtaa gactctgaaa cactggttaa tgttttcatt actctgttat atttctccat 841 cccctgtgac aagcactatg ctagatc (2) INFORMATION FOR SEQ ID NO:2769: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: _base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2769 1 gaattccggc ctgtgaatcc atctggttct tggacttttt ttggttggta agctattgat 61 tattgccaca atttcagatc ccgttattgg tctattcaga gattcaactt cttcctggtt 121 tagtcttggg agagtgtgtg tgttgaggaa tttatccatt tctcctagat tttctagttt 181 atttgcgtag aggtgtttgt agatattctc tgatggtagt ttgtatttgt gagggatcgg 241 tgatgatatc ccctttatca ttttttattg cgtgtatttg attcttctct ctttttttct 301 ttattaggct tgctagcggt ctatcaattt tgttgatcct ttcaaaaaac cagctcctgg 361 attcattaat tttttgaagg gttttttgtg tctctatttc cttcagttct gctctgattt 421 tagttatttc tgccttctg ctagcttaag gagtttcatt cttgttgccc aggctggagt 481 gcagtggagc aatctcggct cactgcaatc tctgtctcct gggttcaagg gattctcttg 541 cctcagcctc ccgagtatct gggattacag gcgcccacca ccatgctggc taattttata 601 tttttagtag agatggggtt tcaccatgtt gcccaggctg gtctcaactc ctgacctcag 661 gtgatccacc cacctctgcc tcccaaagtg ctgggattac aggcatgagc caccacacct 721 ggccacaagt tgcaaaactt ttctaatcct tgtcattgaa ataaattgga ttaacaagaa 781 aggaaaacct gccattggaa tcctaggcaa agaatgaacc ctagctcctt actggggtga 841 tcgttaggta catgagaagc aaaggaaaac tttttgctgg aagttggaag ttggttctgc 901 caagagcacc tgagccaagg gcctctccag gaagggtctt tagggtggtg gccagacaca 961 tctcgctcca ttcccactca ctgtttttca gaactatttt ccaagcccga actggaatct 1021 tccttcacac atctggacca aggtgaaaga ctgaacctgt cctgctccat cccaggagca 1081 cctccagcca acttcaccat ccagaaggaa gatacgattg tgtcacagac tcaagatttc 1141 accaagatag cctcaaagtc ggacagtggg acgtatatct gcactgcagg tattgacaaa 1201 gtggtcaaga aaagcaacac agtccagata gtcgtatgtg gtgagtatat tgttgcgact 1261 cagaggacat ccggggttga atgggagaaa ggaaatttat ctgcagctgc cgccctctcc 1321 ggtctccggt ctgagcagac tcaggcaggg taagaactag agggagagaa gtgcgaaatc 1381 aaaggccaaa gaaacaagga ggtattcctg ctcagaacac tgattcactg atgatgatgt 1441 ggcctctgac ttgcaagatt ctggcaagat tctgcctcct ggagcaagac ccacccaaaa 1501 gttcaggaag gaaacactac ttagtcaatg ttaaactttt cttttttttt tttgagacgt 1561 gtcgcccagg ctagagtgca gtggcacgat agctcactgc aacctctgcc tcctaggttc 1621 aagtgatctc ctgcctcagc ctcccaagta gctgggatta caggtgccca ccaccacgtc 1681 tgcctaattt ttgtattttt atttttatta cttttattta tttatttatt tatttttttt 1741 cggtctgtca cccaggctgg cagtgccagt ggcacaatct gggcatcact ggaaagcatc 1801 cgcactcctg ggtacacgag cattctcctg cctcagccct cccaagtggg tgtggactac 1861 aggacacacc gt (2) INFORMATION FOR SEQ ID NO:2770: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2770 1 tcacttgagt ccaggagttc aagaccagcc tgagcacata gtgagaccct gtctctacaa 61 aaaataaaga attagccagg tgtggtgtgc acctatagtc ccagctactc gggaggctga 121 ggtaggagga ttgcttgatt ctgggaggtt gtagtgagct gtcatcgcac cagtgcactc 181 cagcctgggt aatagagtga gaccctgtct caaatacaca cacacacaca cacacacaca 241 cattttgttg gctacttgtt gtactttttc tatgttttct gtgtctttgc tcaacacaag 301 aaaagtatat tatgtgtgca tgtgcgtgtg agatatggta aaatatgaac atgtatttct 361 ggggatgtaa tgttttcctt gaatttctgt cattctctgt tttgcttatt gtacttctct 421 ttccctttcc cttctcacca cacacacaca cacacacaca cacacacaca cacagcctgt 481 cagtctcata ggtgtcctat aaaggtaaat ggcaggcagg caittgaaat tacagcaggg 541 atagaaagca aaactcaggc tttggaggag gaacctcttg tgctggatgc tttgttttta 601 ccttcagtgc cttttggatt gtttctccct ctgttctaga aatgctctcc cagcccagga 661 tttcttatga tgcccagttt gaggtcataa aaggacagac catcgaagtc cgttgcgaat 721 cgatcagtgg aactttgcct atttcttacc aacttttaaa aacaagtaaa gttttggaga 781 atagtaccaa gaactcaaat gatcctgcgg tattcaaaga caaccccact gaagacgtcg WO 00/09525 PCT/US99/17712 EPI-109 1039 841 aataccagtg tgttgcagat aattgccatt cccacgccaa aatgttaagt gaggttctga 901 gggtgaaggt gataggtaag ttgctgtgct gtgagaagaa atcatgtggg cttggggcat 961 tctttcaccc ccagggactg tggggacaaL aagagaagta gggggccagg tgcggtggct 1021 catgcctgta atcccagcac tttaggaggc caaggccggt gaatcattga ggccaggagt 1081 tcaagaccag cctggccaac atggtgaaac cccatctcta ctaaaaatac aaaaattagc 1141 tgggcatgat ggcgtgcgcc tataatccca gccactcggg aggctgaggc aggagaattg 1201 cttgaaccca ggaagcacag gttgcactga gccaagttgc gccattgcac tccagcctga 1261 gcaacaagag cgaaactcca tctaaaaaaa aaaaagcgag agaagtagtg ggtgcttatg 1321 caaagtccat atactagata tgcaccaaag cagggccaag gttcagtaaa ggaggctgga 1381 aaatatttgg gggctattga tgaggacaat ataatctctt tccagaacct ttcaacaaac 1441 tgctaaaaqa tgataagcat gaaagtgtcc tgactgcagg aagcactgaa gttgtgcata 1501 tgggcttccc ttagcacttt ctccttttca gatacactgt tctgagaatt gtagatcagg 1561 actctgctgt tgtgactcct agccggggaa ccctgccttg tgtgaattcg agattagcct 1621 ggccaacatg gtgaaatcct gtctctaata aaaatacaaa aaattagctg ggtgtggtgg 1681 tgggcacctt taatgccagc tactcgggag gctgaggcac aagaatcatt tgaacctggg 1741 aggcagaggc tgcagtgagc caatatcatt ccgctacact ccagcctggg caacggagca 1801 agactccatc tcaaaaaaaa aaaaaattaa cattacatag actaagcacc taatggtgtg 1861 aggcatacaa aaaagaagac atattctttg tttcaatgct gtggtaagaa acacaagctc 1921 tcctaatgaa aatgatggac aaacatctga atcatactac caataagcat agaaaaaatg 1981 ttgggggtca tgtttggttg tcacgtgaac tatatcctta cagtgatggt gatagtaatt 2041 tagggtatgc cagacttcat ctagcttaag tgggtaaaca ttgtgaaaaa gctgggctag 2101 gtgccagggc ttgagaatgg gtggccagag aaggctgaag atggctgaac atctccagca 2161 aacacatgag ccaaaaggtc ccatggggca cttcaaaaga ctgtgcgcag ccaggtgcgg 2221 tggctcacgc ctataatccc agcactttgg gagaccgaat ggggtggatc acttgagccc 2281 agaggtttgt gactagcttg gccaacatgg caaaaccccg tctctactaa aaatacaaaa 2341 attagcccag cgtggtggtg ggtgtcctgt agccccagct actcaggtgg ctgaggtggt 2401 agaatcactt gaatccagga ggcagaggtt gcagtgagcc aagatcgtgc cactgcactc 2461 cagcctgggt gacagagtga gactctatct ccacaaaaaa aaaaaaaaaa aaaaaaatta 2521 aaggactgtg gccaaatcag atggctggaa acaaaggctg gagtttggga atggagaatc 2581 accggatatg agctgaaaaa gtggctgagc ctaagcgtga caggtgtcag gtgccagtct 2641 caggagtagg caattgtcct gcatgcagtg aaaagccaga agatggaagg aaggacagga 2701 tgcaaatgag ttctcggaac gatccacctg gtggctgggt cagggagcag gcatggtgac 2761 ttcagacctc atggtacgtt agaggctaat gtgaagccca tgtgaagctg ttggtttaaa 2821 ctgggtcgat atcagtggca cacatttact gaccatgtgt ccagccctgt gtgaagtact 2881 gtagtaaatt gctccaatgg aaactcacaa taaccacaga aggccagtaa cagcattgtc 2941 gttattttat catgacgcaa ctgaggctta gggcagacag ctggtgggtg gtgggactgg 3001 gatttgagcc cactggtgtc ccaggcccgg agcttggctt cttccattgt cttaccacag 3061 cctgcactca caggagagtg actcataagt tacaatacca tctgctgacc atctgctctc 3121 acactagaag gaaagtctac ttggggagac aatttaggat ccgaattttg gtagttgagg 3181 atggagctag gaaaagcgga tacaggaggt agccaagttc tgcttggacc tgcagggagt 3241 gaggctggcc gggctccagg tggaaatccc caggtgaaaa gggagacttg gagttcagga 3301 aagtaacctg gactggagcc ataggtttag gtgtcagtgg ctcagagaca gaagctcagc 3361 gtgtaggtga aatcacccag gaggagaatg gggatggaaa actgaggatt gaattttgca 3421 aaatgttcat acttccgggg aaaacaaaga ataaccagtg aataagaaag gggtgccagg 3481 taagaaggga agagaatcag agtcatgagg aaccccagaa ccccagaaaa agctgagttc 3541 cacgtaagac ctgggcaaca gtgaagtatg gagagcccaa gattgggagc gtggaggaag 3601 agcatccacc actgaattta atcagccccg gactcaggga cgttggttgg ggaatcaagt 3661 gaccttccca gtttcttcaa aacttgagag agagtgcagt gtcacaagat tgtgactaca 3721 aaagagtgca gtcagatttc aggggtaaca agaaagtgtg aaataaggga gtcaaagcat 3781 aaaggaaaaa ggagaaaaaa tggccgatag ctagagaagg cgtgggtcaa gattgtctgt 3841 ggcctggcat ggtggcttat gcctgtaatc ccagcatttt ggaaggccga ggtgggcaaa 3901 tcacctgagg tcaggaattc aagaccagcc tggccaacag ggcaaaaccc cgtctctaaa 3961 acaacaacaa caacaaaaaa atccaaaaag ttagctgggc ctggtgggcg cacctgtcat 4021 tccagctact cgggaggctg aggcaggaga tttgcttgaa cccaggaggc acacgttgcg 4081 gtaagctgag attataccac tgcactccag cctgggtgat aagagcggga ctctgtctca 4141 gaggaaaaaa aaaaaagttg agcagtggct gtctcatgtt cctcttcctc tgcccttctt 4201 tgctcagtgt gaatcctttt cctgcttttc agccccggtg gatgaggtcc agatttctat 4261 cctgtcaagt aaggtggtgg agtctggaga ggacattgtg ctgcaatgtg ctgtgaatga 4321 aggatctggt cccatcacct ataagtttta cagagaaaaa gagggcaaac ccttctatca 4381 aatgacctca aatgccaccc aggcattttg gaccaagcag aaggctaaca aggaacagga 4441 gggagagtat tactgcacag ccttcaacag agccaaccac gcctccagtg tccccagaag 4501 caaaatactg acagtcagag gtgagtcagg gtctccatag caagctgtgc tgtgggcccc 4561 caagggcaag accagaaaac accccccttg taagagggag tttgggggga gtctagctta 4621 tgtgactgaa ggctaggaga gtaatgtcct ccaggctctt ggttgcaagt gacagaaacc 4681 cactcaaatt aagtaaaaaa gagaaatcga ctattataag gaattgggag aatgtcacat 4741 cgttccaatt acaaattgtt ggcagactca ccattgagtc atcttgggtc aaacatccaa 4801 ccacagacca cctgtagcca aggggattgg gtcacgcaga acagacatga ttggggaacc 4861 acttatgtgg gtgtgggggc ggtttcctgg agaagaagag ggctgaaaac acatgccaaa 4921 aaggagtcta ctccacttga gccctggagt tggagaccag cctgggcaac atggtgaaac 4981 cctgtctcta caaaaagtac aaaaataggc tgggcgcagt ggctcatacc tgtaatccca 5041 gctactcggg aggctgagac atgagaatca cttgaaccca ggaggtagag gttgcagtga 5101 gcagagcttg ctccactgca ctccagcctg ggcaacagag caagactctg cctcaaaaat 5161 caaaccaaca aaaaatagct gtgtgtggtg gtgtgctcct gtagtcccag ctactcggga 5221 ggctgaggtg gaaggattgc tcaagcccag gaagttgagg ctgcagtgag ctgtcatcag 5281 cctctagcct gggtgacaga gtgagaccc gttcaaaaag aaagaaaaag aaaagagtct WO 00/09525 PCT/US99/17712 EPI-109 1040 5341 acccagcaaa gctggtttgt tccctccttg aggaccacag ctgacctcta tttgtagcag 5401 aaacaatcat ttctgcacca gctctgagtg cagaacccct cagaggtaga tggatgctaa 5461 ggcaagctgc cagttacaag agctgtgaga atcagactga cttttgttgc ttaaggcctg 5521 atattatttc ttcctggcag aggaagagcc tatatacaaa aaaaattttt tgttttgttt 5581 tgttttcagt cattcttgcc ccatggaaga aaggacttat tgcagtggtt atcatcggag 5641 tgatcattgc tctcttgatc attgcggcca aatgttattt tctgaggaaa gccaagggtg 5701 agcatagttc tttccttcca tactgactgg tcgtccttgc caggaaacca gccagggatg 5761 cgtggtgctt ttctgacccc tggattcagc taggcaaaaa tgaaagctat tattttcctc 5821 attgggcaaa ccagaaaaga taaaatttgg gggaaattac atctttgtgt ggttagaaga 5881 agccatttct gtagatttgt ccacacctag tcctgtaatg cgtgtagagt ggggtgcaag 5941 cgtcttggag acacacaaac atgcgcataa cacccacatg ttgcacacac acattg (2) INFORMATION FOR SEQ ID NO:2771: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2771 1 acctctttct tttctgtctt ttgaaaaaga gtgaatatat ttgccttctt tttctctctt 61 tttctgggta ttcaatcttc tgggaagtcc aaacgtagct gaaaagagtg ttccttcaca 121 gcttactagg agtaaaacaa aaagaaaaga aaagtgtttt ctatctatta ggttagtgca 181 aaagccattg gcgttttggc cattatagtg gtatggatgt gggtactgta tactgacttt 241 ggtttttcgt tttctgtttt taaagccaag cagatgccag tggaaatgtc caggtgagtg 301 tatttgtaag aagggggcgg ctgctctgtg agcacggtgg acatgtctgg agggagattc 361 tggtcattag gaagttttca gtggctcttg gcaaacttag aaaaatatag gccttccttg 421 ggtgtgagtt gtgtgtgtga gttgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtatctc 481 cgtggaagaa tgccaattgt cctttcatgg gaaggaatgg cttttattct gagatcatgt 541 ccttcctaca tgattatttg tgaaatctcc ctttctttat gaaattataa tggtagtaga 601 taatttttta aaatttgaca aaatagagtt ggcctttaaa aaatggtttt actaccttta 661 ctgttgttga aatcccaaat caaaagtata gaaatgattg ctctgttcca gagagaaaca 721 gtagcgtggg ataagaattt cagggggctt ggtagtagcc tgtgaaggac tccggtattc 781 atgtgtgctt tggtctgatg ttatttaata ggaaagtt (2) INFORMATION FOR SEQ ID NO:2772: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2772 1 aaaaaaaaaa aaagtttttt tacataatcc ttggagctgc caaaaaatat ttgttttcca 61 aatgagagag taaagttttc cttaccttgg aaaactcttc ctggttttct catgatcttc 121 ccttgtttac tttggtggtt tggggttaga acaataacaa caacaaatat atctatatat 181 tgttttctgt ttttatattt cattttaaag gccagcagta ccacttctga actccaacaa 241 cgagaaaatg tcagatccca atatggaagc taacagtcat tacggtaaag tcatgttctc 301 ctgccattta taattccccc caacttgcta catacttcct tacccctctc agaagcagaa 361 tatgtaagtg gtgggattac agttggaaga gaaaccctgg cttcaacagg gtacttcatc 421 tcatcagcca ctgggccatg taatatacgg aaacgtaaaa ggaaaggtaa catattttat 481 tctaactttg ccaccttcca aactccccgt agaagaaaga tggagaataa tcataatgcc 541 ttcaaagact ttgaacattg ctccagcgta atattataat tctccatttt caagacagag 601 acagatattg aatgaaacat tggtaaacat cttctcagat ggaattatta caagcacaag 661 acagttttac ttcaaatttg gcacaaaggg aaagcaattt caatattctc tcagtaaagg 721 cataaataaa gtgttccaac taagaaaata tctattcata aggctcatca gtagcttcag 781 ggtcagctca gctgaatgag taggcagtcc taggagttct taatcccagg ttagtaagaa 841 aattgctcaa gcatttcagc aggatgctac ttacttccca gaggggggta ttattacatc 901 acaaaaagtc ctgtcccaga ccaaatttgg ggacactctt cctctt (2) INFORMATION FOR SEQ ID NO:2773: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2773 1 atagccacga ctcaaatata ttgatcttag aatctaaaag acttaggtct gggcgcggtg 61 gctcacgcct gtaatctcaa cactttggga ggccgaggta ggtggatcac ttgaggtcag 121 cagttcaaaa accacctggc caacatggtg taaccctgt tctactaaaa atacaaaaaa 181 ttagctgggc atggtggtag atgttataa tcccagctac tcaggcaggc tgaggcagga 241 gaataccctt gaacctggga ggtggaggtt gcatgacctg a 1 tggacctcaa catgcacacc agtccgagca acaagagcga aactccatct caaaaaagaa WO 00/09525 PCT/US99/17712 EPI-109 1041 61 agaaagaaag aaactatatt caggccaggc atggtagutc atgcctataa ccccagctct 121 ttgggaggct gaggtgggag gatcattgag cccaggagtt ggagaccagc ctgtgcaaca 181 aagcgagaca tggagaatgt ggaacgaggg acccaggacc cagagacagt gctggttgtc 241 actacactga ataaatcagg cttgactttg ttaggggtac tgaattttta aaagggtttt 301 agaaaactag aatttccctt gtcactcacc ctaattgtta tttttcaact aggtcacaat 361 gacgatgtca gaaaccatgc aatgaaacca ataaatgata ataaaggtaa ttatctaatt 421 acatgttttt attagaacca acttttacat taaaaaaaag actcatagga aaagaaaact 481 aaaacttgaa ggactgtgga taatttccca cctctcttaa tgaccctgta cccagccgat 541 gtgtcaatga aggtagctag ctgctttcac cagagatgct atctagtgtc ctcagtggga 601 agtacctaaa tcaaagtagg gaagaactgg gttatactca aaaaa (2) INFORMATION FOR SEQ ID NO:2774: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2774 1 acaacaactc tgtggtttct ttaggcagag cctctgaact cagacgtgca gtacacggaa 61 gttcaagtgt cctcagctga gtctcacaaa ggtaagtgcc actcgagtga gtccccaggc 121 attcgctttg gcttgggttt aaaccccagt ggtggcgggg gtgctgtgtt cagtgagaag 181 agtctgtgca ccctcagtcg ctccaaagga agtgattagc agacctaccg gcctgctaag 241 actggaagga gcaaggcccc tggcctggcc tgtctctgag ctgtaaaatt tcaataattt 301 aaaagaaaaa aagaaaaggc caggcactgt ggctcacacc tgtaatccta gcactttggg 361 aggccaaggc gggtggatca cctgagatca (2) INFORMATION FOR SEQ ID NO:2775: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear. (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2775 1 tatattttat atattaatat ataaatataa atacatatat aatatataat atatgttttc 61 tttgtgtata atatatattt tataatattt tatatatttt tattttttat ttttatatat 121 tttatatata atatttttat atttatatta tttatatatt ttttatttta tatatatata 181 tatatttttt tttttctttg ttgagacgga gtctactctc tgcccaggct ggggtgcagt 241 tgcgagatct (2) INFORMATION FOR SEQ ID NO:2776: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2776 1 tgcaaacctc tgcctccggg ttaaagcagc attctcctcc ctcagcctcc cgagtagctg 61 ggattacagg catgtcaccg ccacagccgg gtaatttatt tatttttttt ttgtattttt 121 aagtagagat gggatttcac catgttggcc agcgtgaact cgaacttctg acttcaaaag 181 atccaccccc ctcagcctcc caaagtgctg ggattacagg tgtgag (2) INFORMATION FOR SEQ ID NO:2777: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2777 1 gaattcaatt tgagttttcc agacccgtcc tcctccttgg cagctaagga gcagtgtggg 61 aagtcaggcc tgagcctcag gtgttccctc tctgccttcc tgtgggtgga gagccaggta 121 ttaccaggta cgaaaagggg ctttgtgggt acaaggctca gtggtgagta catttgacct 181 ggtcttgacc aagccagttc cctgctctca agacttcctc ctcctatgga ggaggggttg 241 ggaaccacat ccagctctga ccctagtggc aggcgaccaa gtggtcactt ggggtggagg 301 aggggcagga aggaactcag taaatcctgg tttgctgcat gtttgctctg agactaattg 361 ctgggaaaac cccatgacgt tggaagccat ctccttctct gttatcacag agaaaaacag 421 aagccaaaat aaagccccat ccggaaacat ccctgacagc agagacaaag agcctgccag 481 cctggtttac tcattagcaa gcagctgctc cctggagtgg gtggggagga gaggtagtga 541 tgagctgcaa ctctgcctgc ccacccatca cttaactggg cagatttggg ggcagctgca 601 actctagaag ctccaccaag aagcagaacc ccccaggccc aaacaccaag ccctctccct 661 ccatttattc ctcacctgcc ccagccccca ctgtgggcct gggtgggagg gtgagctggc WO 00/09525 PCT/US99/17712 EPI-109 1042 721 cgtgaccacc ccaccatgcg cctggtatat ggtgtttgat agcatttgtt gcagtgtctg 781 cgttgtttgt gcacctgtct gcctcacagc ctggagctcc tgaaagctgg ggaccaggcc 841 cgatcacctt tcctcttcca cagtgcgggg ttcacactag gtgtctagga ttctgctgag 901 tgagtgattt ggccaggcct gacatcaagc agagggtgtc ttggggatgt ggaggatccc 961 ccaatagggt tggggatccc tacagcttcc cttgagggcc ccacatctgg tgccacagaa 1021 agagagtgag gggtgtgtgg gcatctctgc tgtcccagca gtgtggtgcc ctggtagctc 1081 agccactcta ctgagttcca aatcctgttt gggtgccctg ggggaagtca gtgtaagggc 1141 ctagtca (2) INFORMATION FOR SEQ ID NO:2778: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2778 1 aaggagggaa atccacttga ccatggcaca ggaacccccc ttacccaatc tgggccttcc 61 ctttccccca tctgtaaaag gagaacagtg cccacacgac atcagcctct tttcctacag 121 tgagccttcc tggccctttg tgcagtagac aggagctggg aagtgcccag gttccatcct 181 gtttcctcag ggttggtggg tatgtatgtg tgtgcacacc ctgtgtgcat gagtgtgtgc 241 acacccagat tgcatgtttg tacatacagt gtgtatacaa tgtgtgtaga cacatcctat 301 acactgtatgagggtataca tagcatgtat acacattgtg tgcatgagtg tgcgtgtgta 361 tatgctgtgt gtgtattttt gtatacacat cctgtgccca taccccagtg taaggtaaac 421 agatggcagg aagggcgccc ttgagtctcc tccaggtata cgccacaccc tgggtcagtc 481 atcatgctgc catattgaga gggtctagcc cagaggatct cagccctgtc tgcatattag 541 ggcccctgag gagatcctaa aaaaccagca ccagggaccc ccccagacca atccaaccag 601 aagctgcagt gaggcccagg agccagcagt gaaaacagcc agcccagctg tctatctctg 661 taagagttct cagtcccagc tattcctagg gtcactgaca acccccaggc tctaacccag 721 acctcaggat cttgttctgg atcccggggt ctgggctctc aggtgattgg gaggccatag 781 cccaaccctg cgttgaggga cctggcagaa tgtctggaca agggtcacgg tggcagggga 841 agaggagtgg gggcagcaag ctggaggctg caggcccttg ctggggggct ctccatccgt 901 gggcccctca ggtccagggg ttcctctggt gcatgtggcc ctgctccaca atggcctgct 961 gacctcctat tcccagactg ggagtgacgc tcgttagacc aagacctcct tcttcttctt 1021 cttttttttt tttgggaggt ggtgtgtcac tgtgttgccc aggctggagt gcagtggcgc 1081 aatcttggct cactgcaacc tctgcatcct gggttcaagc gattctcgtc ccttagctct 1141 cgagtaactg ggatcacagg gacgcaccac catgcccggt taattttttg gaatttttag 1201 tagagacggg gtttcggcat gttggccaga atggtctcaa cctcctgacc tcaagtgatc 1261 ttgccccctc aacctcccaa agtgctggga ttacaggtat gagccacctt gcccagccag 1321 gatcttctaa catcagaaat gacaaggtct ctgggtgctt ctggacctgg ttctggtggg 1381 gtgcagtggt ggggtacagc cttgcctgca gagcctcaga ccttttccta tgactgcagt 1441 ggactgacct cgttcccaga ggcagctact aacttatgcc tggtcctttt tccagatcta 1501 ggaaagaagg acacagagac agtgtacagt gaagtccgga aagctgtccc tggtgagtga 1561 gggtctccag tgccccagcc tgggggatgc cccctataat cactgatggg ggcttgggag 1621 tgggcagaga aaagaagaag caaagaaggg caaaaaaggg gtggcacctc ttacaccagc 1681 gctgtgggct tcctctctcc caccaccctt aaaaagtcac ctcgggtcac atttactatt 1741 catgtagtca acgagcgctt cttgaatgct tactgacccc agccggtgac ccttacctgc 1801 tccccacaca ggccctggtg gctggggttc cccaaggtct tggacgtcga gtgttttgct 1861 ttggagaccc ccagtagctt cagcctttct tcttgttttc ttttttctct tttttttttg 1921 gggatacgga gtctcgctct gtcactcagg ctggagtgca gtggtgcaat ctcgactcac 1981 tgcaacctcc acttcccgga tttaagtgat tctcctgcct cagcctccca agtagatggg 2041 attacaggcg cctgtcacca cactcagcta attttttttt tttatatttg ggagacagag 2101 tttcgctctt gatgcccagg ctggggtgca atggag (2) INFORMATION FOR SEQ ID NO:2779: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2779 1 tgctgggatt accaagtgtg accccccgcc ccagcagctt cagcttttct gacaagaaga 61 ctgactttgg gagtgggtgt gggtttgcgg atctactcta tttcctttgg ttcggctgcc 121 cccacttcgc ttcccgtgac gacccactgc ttactcatga aagggcttcc cccagagctg 181, agcacagagc ttaagcagac ccggaactgg gggagctcaa caagtccttt ttttcggtgg 241 gggggtataa taactgtatt caattcaggt gaaatgaaat acacaatgac aacttttaaa 301 ttctgaaggt aagtcagcaa tccgaaagac gtaaacattg tgggggaaat agtgactgtg 361 tgagtatctc gctttgtaca gcagacctct atttaagtgg gttcttggaa agggaatcat 421 taaaatggtc caggacattt ctgcaaaggg tgcctactca gcctaggcgt ggtggctcat 481 taagcactca gtaagtgctt tatttattta ccccaaataa ataaataaat ataaaaggat 541 gactcctccg agtacagtcg ccaaaccagc agcagcaatc tcgggcccag cccagaccca 601 caaaactagt ctctggaatc tgaacttagc cagcttcaga tgtttctgat gctgccaata 661 tttgagaagc actgtttgtg ttttgttttg tttttttgtt tgaaacagag tctcactctg 721 tcacccagac tggagtacag cagtgccatc tcagctgact gcaactccgt gcaacacccc 781 ccagccccta aggcttaagc gatcctccca agtagctaga accacagaca cacaccacca WO 00/09525 PCTUS99/17712 EPI-109 1043 841 tgcccagcta agtttttgta tttttggtag agatgaggtt ttaccatgtt gcccagactg 901 gtgttgaatt cctgagctca agcaatccac ccccttcggc ctcccaaagt gctgggatta 961 caagcgtgag ccactgtgcc aggcaaaaag cactgtttta gaagaaccat ccaattctct 1021 gaggaccctg ctttttatct gaaatagcga tcacttctta attcactttt aaaagttggt 1081 atatctacaa gaagaataga aactcaaccc ttgtggaact tgaccctgaa taatttttga 1141 aaaaccaatt ctctggggaa tttttagctc aaatacctca ttt (2) INFORMATION FOR SEQ ID NO:2780: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2780 1 aaaaaaaaaa aaaaaaagaa gaagtagttt ctgcttttag tcagataaac aagctctggg 61 gagacttcct tctacatctg aaccagctca aaacaatcct tatgccaaag gggcatattt 121 tgtggtggca tattctgatt tccttcatct gctttagggc agctggctgt tcaagtgggt 181 tctctcgggg tctccaggtt ggttctaga (2) INFORMATION FOR SEQ ID NO:2781: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2781 1 ctttctttct ttcctttctt tttttttttt ttgagacagg gtcttcgctc tgtcacccag 61 gctggagtgc agtggcgcga tcgcagctca ctgcaacctc cagctcccgg gttcaagtga 121 ttcttctgcc tcagcctcct gagtagctgg gaccacagct actgccacca cccccgggta 181 attttttttg tatttttagt agagacggtg tttcaccata ttggtcaggc tgatctcgaa 241 ctccagacct caggtgatcc acctgccttg gcctcccaaa gtgctgggat aacaggtgtg 301 agacaccacg cccggccaga tcatat (2) INFORMATION FOR SEQ ID NO:2782: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2782 1 gatcctatct acgggaaaca tgaagagtaa tattctactg tggcctgggt gaccctgggc 61 aagtcataga gcctctcaag accttggtca ccttctctgt gagatgaggt atgggctgga 121 ggcaggtcag tggtcctcgg gctttattaa aacatcaata gtttggcgca ccccactccc 181 tgtgaatttc ccattcacta ggtctggagc ggtgccgaaa acgtgcattt ctaacaggtg 241 tccacacgca gctgctcgcc gacacgctgg ggcccgggct ttgagaacca ctcttgatgc 301 agcatgttcc tttctgattg tgccacgcta aggctctgct tcttgttgga aggagtaggg 361 tctttctcac cctccagaaa tcctggaggg atctttcagc attggtgggc aggtaaaacc 421 cagaaacact gtgcttatta gagggaaggt tgtattgagt gacccccaat aaaacagggg 481 gcccagggcc gcgcgcagtg gctcacgcct gtaatcccag caatttggga ggctaaggcg 541 ggcggatcat gaggtcagga gatcgagacc atcctggcta acacggtgga aaccccatct 601 ctactaaaaa tacaaaaaat tagctggacg tggt (2) INFORMATION FOR SEQ ID NO:2783: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2783 1 agataagcaa tagggcatgg gcaggcctgc ctccaaggag cagccccagg gccgaggaga 61 gagagctggc gctggcccag gggacttgag tttgatggga aagcttgcag acagtggggg 121 agctgcctgg tctttccagt cttggctttt ggctctaagc acagcttttt tttttttttt 181 tttaattgtt gtatcatgag gcgccttcca ctcagctgcc tccccacgtt aggggatgga 241 cacagcactg gcagggatcc tgtgtgtctc agtttcccta ttgactctct gtggcctaga 301 gatgtatggt agaattccac actatgcttt ttttccaccg tgtttttttt tttttttttt 361 tttgagacag ggtctctctc tgtcacccag gctggagtgc agtggcgcaa tcttggctca 421 ctgcaacctc cacctcccca ggcaggcccc tctgactcag ctgggactac aggcatgcac 481 caccagcacc cagcaaaata tttttatatt ttagtagaga tggggtttcg tcacattggc 541 caggctggtc ttgaactcca gagctcaagc aatccgcccg cctcagcctc ccaaagtgct 601 gggattacaa tgcccagccc actttttttt ttacttttta caattttatt cttaaaattg WO 00/09525 PCT/US99/17712 EPI-109 1044 661 tggtaaaaca catatcacat aaaatttacc attttaactc taagtatcca gctcagtggc 721 actaagacta cacttttat tgtcatagcg tggtgaacag agaagagaat gctactgcgt 781 ctcgtggaga gaggccaggg gataccgcta aacatgcgac aatgcacagg acagtcccct 841 ccccaccaca aaacaccacc cagcccaaaa tttcaacagg gccaccatgg agaaaccctg 901 gccagaggaa ttcaccrcct gcaactcctc caacaggaga gctggttttc ctctccagta 961 ccagcttgtg gctgccctct gtcttgggag ggtgacttaa gggcacatcc cacctgatta 1021 ctgtgggctc tggatgggtg ctgagtcttg gtctggggaa cag (2) INFORMATION FOR SEQ ID NO:2784: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2784 1 aaattaccca ggcatggtgg tgtgcgcctg tagtcccacc aacttgggag gctgaggcag 61 gagaattcct tgaatctggg aggcggaggg tgcagtgagc cgagatagtg ccagctgagg 121 caggagaatt ccctggaggt agaggttacg gtgagccaag atggcgccac cacactccag 181 cctgagtgac aaagcgagac tctgtctcaa aaaaaaaaaa ataaagaaaa ttttaaatga 241 agtgccaggg actttatgcg catgtcatgt ggagctagct acagggtccc ggggaagctg 301 tcttgcacaa aggagccata aacctctaag ggcactgccg gctgatgtct cctggctctc 361 gcctcctccc tcttttctcg acctgctcct gaccctgtga tgttgttggg gcagttgaac 421 tgggttattt gcgttgctca ctgccatgtc atcctttgtt ttgtagatgc cgtggaaagc 481 agatactctg taagtacaca tttcatatac attatattta aaagtactcc actgaacagt 541 gaaatatttc cagactcacc cacgcctgca ttcacacgaa ttcttccccg ctccctagcc 601 tgttcagacc agaagccctg ggcttctctg actagccttg gccagttctg atttcgaata 661 ttctctcctg caatttccat cattacatct cagcccacac gtgaagggat tgggactctg 721 gggtgcttag cgccaaacaa gcaaagcaca catttcgttt aacgccaaag tctaggctct 781 ggaagtgagg cagatctagg gtgtatgctt ggaggagtgg agcagctgac agctcattgc 841 aatttagccg atactaatta ccccctacac accaggccat cagctgcagg aggacaccca 901 agcttcttga cctcagttca ccttctgatg agggaatcag acatgtgatc acttatcata 961 aagccaagtg agctatgcca gagcctatgg gaacacagaa cagagaccta gctagtgccc 1021 tcttccccaa ggaatcattt ggaatggccc atgaagaatg aatggagtga tgatgccagc 1081 attgagggag aaagatcagc aggagcacaa gggtgaggga tgaccagttt caagcagtgt 1141 gggatgggaa agaagagtgt gacagtgaca agtgacggga gaaagataag tcagggctta 1201 aatccaaagg atttacatcc cttgttaaga agcttcattc tgtaggaaat ggagttagga 1261 atctgcattt ggcagatggg agggtttatg aaagacacag aggcccacgt tcaacttttg 1321 caaagacgtg tcttccaatc ccaacctttt tgtgagctac ccagcaatgc aggagttaac 1381 tgggcagcta atatctgaag aaatgaggca tttgccgcat aaacttcttt taggtctggg 1441 aagaactttc agcaaagatt tcaggtagct cttccagtgg cccctggctt cctttgtttt 1501 gcccatgtca ggactcttgt aaaacagagc tc (2) INFORMATION FOR SEQ ID NO:2785: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2785 1 gagctccagc tttccagctg tcttttgggt gagccgtct tcctcaagct caagcttcct 61 tatctataaa gtggagacgg tgatgacaat gatgaaaga gcaacctatt aggattttaa 121 ggatgaaatg agcaactgca accaccatat aaaagctgca agctgcaaac caccatataa 181 aagctggttg atctcaagct cttttcatca cttgggcaat agtaggtgtg gatgggggac 241 ttaacttgat ttggccatga aatgaccctg ccacatatgg agaatgtagc agttgcttac 301 ccaaggcata ggattcaacc aaggccaggc tttgacttag gaatcagaga cccacattaa 361 catttgactt cccgcttctt agccatgtca ccatgggcaa atttcttggc ctctcaagac 421 ctctgcttcc taatctgtat actgggaatc ataaactccc tcacttggtt gttgcaaggg 481 ttgaatgagc ac (2) INFORMATION FOR SEQ ID NO:2786: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2786 1 ctatcaatct ccagagcttt ttctttttaa gtgtgagcga gtttattaga gaagtaaaga 61 gacccaagag tgcctactcc atagacagag cagccactgt gacactgtac ccattaaaca 121 ctaactctcc attgcccctc cagcaacccc tagcacccac tgtctacttt ctgtctctat 181 gtggttgtct atttgaggga catcacataa gtggagtcat atatttgtcc tttcatgtct 241 cccttatttc atttagcaca acgttttcaa gggtttcctg tgttgtgaat atatcagaat WO 00/09525 PCT/US99/17712 EPI-109 1045 301 ttcattctct ttttaaggta gaatcatatc attttaaaac atttcagttg gaccatctaa 361 gttcagtcct tcattttcaa caattaaaaa acagccctca accgggtgca tctcacgtta 421 gctagagaca gaactggagc tagaagtcag atctcttacc aaagttgcct ttcttcttct 481 gtgggtaagt ggggcaccct tgggacgctg tgctgggcgt acatgggtgc ttgatgaagt 541 tacttggtgg actgatgtga ttgatgtcca acatgtatgc agggacagag gctatggtcc 601 ctacagagca ggcatggaga gaaggagaaa tacatacggg caggagccag gagagggagg 661 gtgtagtgag cagagaccgc gccactgcac tccagcctga gtgacagagt gagaatccat 721 ctaaaaaatt gcttactaaa gaagtggtct cctgaggtct taagacgttc ctggcaatgt 781 cttgagtggg tgggagagag cctccagtca ttgagctgtg gaatttcaga ggtgagaacc 841 acacctaacc cccaattact ttcccctgtt tgcctcagtg acacagctgc aggaaccctg 901 gtgggtgttg tattaagta 'a atttgacctt tattctttgc agatctgtga aatgttgtct 961 tctgaggggc cacgtgtatc tgtagtgctg aggactcctt ggggcctctg aagtcacaga 1021 gagaacctgc agggtggggg accagtgtgt gacagccctg cttt.gcattt tctttgagaa 1081 gtgctgtcat tttgcatttc tctccaccag gggaatcttc aatcttgaga ggtgtgatca 1141 taacttgcct tgtttcttgt cgctacagag aacggaaggc tcccttgatg gaacttagac 1201 agcaaggcca gatgcacatc cctggaagga catccatgtt ccgagaagaa cagatgatcc 1261 ctgtatttca agacctctgt gcacttattt atgaacctgc cctgctccca cagaacacag 1321 caattcctca ggctaagctg ccggttctta aatccatcct gctaagttaa tgttgggtag 1381 aaagagatac agaggggctg ttgaatttcc cacataccct ccttccacca agttggaaca 1441 tccttggaaa ttgggaagag cacaagagga gatccagggc aaggccattg ggatattctg 1501 aaacttgaat attttgtttt gtgcagagat aaagaccttt tccatgcacc ctcatacaca 1561 gaaaccaatt ttctttttta tactcaatca tttctagcgc atggcctggt tagaggctgg 1621 ttttttctct tttcctttgg tccttcaaag gcttgtagtt ttgggtagtc cttgttcttt 1681 ggaaatacac agtgctgacc agacagcctc cccctgtccc ctctatgacc tcgccctcca 1741 caaatgggaa aaccagacta cttgggagca ccgcctgtga aataccaacc tgaagacacg 1801 gttcattcag gcaacgcaca aaacagaaaa tgaaggtgga acaagcacat atgttcttca 1861 actgtttttg tctacactct ttctcttttc ctctacatgc tgaaggctga aagacaggaa 1921 agatggtgcc atcagcaaat attattctta attgaaaact tgaaatgtgt atgtttctta 1981 ctaattttta aaaatgtatt ccttgccagg gcaggcaagg tcgtcacgcc tgtaatccca 2041 gcacttcagg aggctgaggt gggcggatc (2) INFORMATION FOR SEQ ID NO:2787: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: _base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTI 'ON: SEQ ID NO:2787 1 gaattccggg agaagtgacc agagcaattt ctgcttttca cagggcgggt ttctcaacgg 61 tgacttgtgg gcagtgcctt ctgctgagcg agtcatggcc cgaaggcaga actaactgtg 121 cctgcagtct tcactctcag gatgcagccg aggtgggccc aaggggccac gatgtggctt 181 ggagtcctgc tgacccttct gctctgttca agccttgagg gtcaagaaaa ctctttcaca 241 atcaacagtg ttgacatgaa gagcctgccg gactggacgg tgcaaaatgg gaagaacctg 301 accctgcagt gcttcgcgga tgtcagcacc acctctcacg tcaagcctca gcaccagatg 361 ctgttctata aggatgacgt gctgttttac aacatctcct ccatgaagag cacagagagt 421 tattttattc ctgaagtccg gatctatgac tcagggacat ataaatgtac tgtgattgtg 481 aacaacaaag agaaaaccac tgcagagtac cagctgttgg tggaaggagt gcccagtccc 541 agggtgacac tggacaagaa agaggccatc caaggtggga tcgtgagggt caactgttct 601 gtcccagagg aaaaggcccc aatacacttc acaattgaaa aacttgaact aaatgaaaaa 661 atggtcaagc tgaaaagaga gaagaattct cgagaccaga attttgtgat actggaattc 721 cccgttgagg aacaggaccg cgttttatcc ttccgatgtc aagctaggat catttctggg 781 atccatatgc agacctcaga atctaccaag agtgaactgg tcaccgtgac ggaatccttc 841 tctacaccca agttccacat cagccccacc ggaatgatca tggaaggagc tcagctccac 901 attaagtgca ccattcaagt gactcacctg gcccaggagt ttccagaaat cataattcag 961 aaggacaagg cgattgtggc ccacaacaga catggcaaca aggctgtgta ctcagtcatg 1021 gccatggtgg agcacagtgg caactacacg tgcaaagtgg agtccagccg catatccaag 1081 gtcagcagca tcgtggtcaa cataacagaa ctattttcca agcccgaact ggaatcttcc 1141 ttcacacatc tggaccaagg tgaaagactg aacctgtcct gctccatccc aggagcacct 1201 ccagccaact tcaccatcca gaaggaagat acgattgtgt cacagactca agatttcacc 1261 aagatagcct caaagtcgga cagtgggacg tatatctgca ctgcaggtat tgacaaagtg 1321 gtcaagaaaa gcaacacagt ccagatagtc gtatgtgaaa tgctctccca gcccaggatt 1381 tcttatgatg cccagtttga ggtcataaaa ggacagacca tcgaagtccg ttgcgaatcg 1441 atcagtggaa ctttgcctat ttcttaccaa cttttaaaaa caagtaaagt tttggagaat 1501 agtaccaaga actcaaatga tcctgcggta ttcaaagaca accccactga agacgtcgaa 1561 taccagtgtg ttgcagataa ttgccattcc catgccaaaa tgttaagtga ggttctgagg 1621 gtgaaggtga tagccccggt ggatgaggtc cagatttcta tcctgtcaag taaggtggtg 1681 gagtctggag aggacattgt gctgcaatgt gctgtgaatg aaggatctgg tcccatcacc 1741 tataagtttt acagagaaaa agagggcaaa cccttctatc aaatgacctc aaatgccacc 1801 caggcatttt ggaccaagca gaaggctagc aaggaacagg agggagagta ttactgcaca 1861 gccttcaaca gagccaacca cgcctccagt gtccccagaa gcaaaatact gacagtcaga 1921 gtcattcttg ccccatggaa gaaaggactt attgcagtgg ttatcatcgg agtgatcatt WO 00/09525 PCT/US99/17712 EPI-109 1046 1981 gctctcttga tcattgcggc caaatgttat tttctgagga aagccaaggc caagcagatg 2041 ccagtggaaa tgtccaggcc agcagtacca cttctgaact ccaacaacga gaaaatgtca 2101 gatcccaata tggaagctaa cagtcattac ggtcacaatg acgatgtcag aaaccatgca 2161 atgaaaccaa taaatgataa taaagagcct ctgaactcag acgtgcagta cacggaagtt 2221 caagtgtcct cagctgagtc tcacaaagat ctaggaaaga aggacacaga gacagtgtac 2281 agtgaagtcc ggaaagctgt ccctgatgcc gtggaaagca gatactctag aacggaaggc 2341 tcccttgatg gaacttagac agcaaggcca gatgcacatc cctggaagga catccatgtt 2401 ccgagaagaa cagataatcc ctgtatttca agacctctgt gcacttattt atgaacctgc 2461 cctgctccca cagaacacag caattcctca ggctaagctg ccggttctta aatccatcct 2521 gctaagttaa tgttgggtag aaagagatac agagggg (2) INFORMATION FOR SEQ ID NO:2788: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2788 1 gaccagagca atttctgctt ttcacagggc gggtttctca acggtgactt gtgggcagtg 61 ccttctgctg agcgagtcat ggcccgaagg cagaactaac tgtgcctgca gtcttcactc 121 tcaggatgca gccgaggtgg gcccaagggg ccacgatgtg gcttggagtc ctgctgaccc 181 ttctgctctg ttcaagcctt gagggtcaag aaaactcttt cacaatcaac agtgttgaca 241 tgaagagcct gccggactgg acggtgcaaa atgggaagaa cctgaccctg cagtgcttcg 301 cggatgtcag caccacctct cacgtcaagc ctcagcacca gatgctgttc tataaggatg 361 acgtgctgtt ttacaacatc tcctccatga agagcacaga gagttatttt attcctgaag 421 tccggatcta tgactcaggg acatataaat gtactgtgat tgtgaacaac aaagagaaaa 481 ccactgcaga gtaccaggtg ttggtggaag gagtgcccag tcccagggtg acactggaca 541 agaaagaggc catccaaggt gggatcgtga gggtcaactg ttctgtccca gaggaaaagg 601 ccccaataca cttcacaatt gaaaaacttg aactaaatga aaaaatggtc aagctgaaaa 661 gagagaagaa ttctcgagac cagaattttg tgatactgga attccccgtt gaggaacagg 721 accgcgtttt atccttccga tgtcaagcta ggatcatttc tgggatccat atgcagacct 781 cagaatctac caagagtgaa ctggtcaccg tgacggaatc cttctctaca cccaagttcc 841 acatcagccc caccggaatg atcatggaag gagctcagct ccacattaag tgcaccattc 901 aagtgactca cctqgcccag gagtttccag aaatcataat tcagaaggac aaggcgattg 961 tggcccacaa cagacatggc aacaaggctg tgtactcagt catggccatg gtggagcaca 1021 gtggcaacta cacgtgcaaa gtggagtcca gccgcatatc caaggtcagc agcatcgtgg 1081 tcaacataac agaactattt tccaagcccg aactggaatc ttccttcaca catctggacc 1141 aaggtgaaag actgaacctg tcctgctcca tcccaggagc acctccagcc aacttcacca 1201 tccagaagga agatacgatt gtgtcacaga ctcaagattt caccaagata gcctcaaagt 1261 cggacagtgg gacgtatatc tgcactgcag gtattgacaa agtggtcaag aaaagcaaca 1321 cagtccagat agtcgtatgt gaaatgctct cccagcccag gatttcttat gatgcccagt 1381 ttgaggtcat aaaaggacag accatcgaag tccgttgcga atcgatcagt ggaactttgc 1441 ctatttctta ccaactttta aaaacaagta aagttttgga gaatagtacc aagaactcaa 1501 atgatcctgc ggtattcaaa gacaacccca ctgaagacgt cgaataccag tgtgttgcag 1561 ataattgcca ttcccacgcc aaaatgttaa gtgaggttct gagggtgaag gtgatagccc 1621 cggtggatga ggtccagatt tctatcctgt caagtaaggt ggtggagtct ggagaggaca 1681 ttgtgctgca atgtgctgtg aatgaaggat ctggtcccat cacctataag ttttacagag 1741 aaaaagaggg caaacccttc tatcaaatga cctcaaatgc cacccaggca ttttggacca 1801 agcagaaggc taacaaggaa caggagggag agtattactg cacagccttc aacagagcca 1861 accacgcctc cagtgtcccc agaagcaaaa tactgacagt cagagtcatt cttgccccat 1921 ggaagaaagg acttattgca gtggttatca tcggagtgat cattgctctc ttgatcattg 1981 cggccaaatg ttattttctg aggaaagcca aggccaagca gatgccagtg gaaatgtcca 2041 ggccagcagt accacttctg aactccaaca acgagaaaat gtcagatccc aatatggaag 2101 ctaacagtca ttacggtcac aatgacgatg tcggaaacca tgcaatgaaa ccaataaatg 2161 ataataaaga gcctctgaac tcagacgtgc agtacacgga agttcaagtg tcctcagctg 2221 agtctcacaa agatctagga aagaaggaca cagagacagt gtacagtgaa gtccggaaaq 2281 ctgtccctga tgccgtggaa agcagatact ctagaacgga aggctccctt gatggaactt 2341 agacagcaag gccagatgca catccctgga aggacatcca tgttccgaga agaacagatg 2401 atccctgtat ttcaagacct ctgtcc 1 gaattccggg agaagtgacc agagcaattt ctgcttttca cagggcgggt ttctcaacgg 61 tgacttgtgg gcagtgcctt ctgctgagcg agtcatggcc cgaaggcaga actaactgtg 121 cctgcagtct tcactctcag gatgcagccg aggtgggccc aaggggccac gatgtggctt 181 ggagtcctgc tgacccttct gctctgttca agccttgagg gtcaagaaaa ctctttcaca 241 atcaacagtg ttgacatgaa gagcctgccg gactggacgg tgcaaaatgg gaagaacctg 301 accctgcagt gcttcgcgga tgtcagcacc acctctcacg tcaagcctca gcaccagatg 361 ctgttctata aggatgacgt gctgttttac aacatctcct ccatgaagag cacagagagt 421 tattttattc ctgaagtccg gatctatgac tcagggacat ataaatgtac tgtgattgtg 481 aacaacaaag agaaaaccac tgcagagtac cagctgttgg tggaaggagt gcccagtccc 541 agggtgacac tggacaagaa agaggccatc caaggtggga tcgtgagggt caactgttct WO 00/09525 PCT/US99/17712 EPI-109 1047 601 gtcccagagg aaaaggcccc aatacacttc acaattgaaa aacttgaact aaatgaaaaa 661 atggtcaagc tgaaaagaga gaagaattct cgagaccaga attttgtgat actggaattc 721 cccgttgagg aacaggaccg cgttttatcc ttccgatgtc aagctaggat catttctggg 781 atccatatgc agacctcaga atctaccaag agtgaactgg tcaccgtgac ggaatccttc 841 tctacaccca agttccacat cagccccacc ggaatgatca tggaaggagc tcagctccac 901 attaagtgca ccattcaagt gactcacctg gcccaggagt ttccaqaaat cataattcag 961 aaggacaagg cgattgtggc ccacaacaga catggcaaca aggctgtgta ctcagtcatg 1021 gccatggtgg agcacagtgg caactacacg tgcaaagtgg agtccagccg catatccaag 1081 gtcagcagca tcgtggtcaa cataacagaa ctattttcca agcccgaact ggaatcttcc 1141 ttcacacatc tggaccaagg tgaaagactg aacctgtcct gctccatccc aggagcacct 1201 ccagccaact tcaccatcca gaaggaagat acgattgtgt cacagactca agatttcacc 1261 aagatagcct caaagtcgga cagtgggacg tatatctgca ctgcaggtat tgacaaagtg 1321 gtcaagaaaa gcaacacagt ccagatagtc gtatgtgaaa tgctctccca gcccaggatt 1381 tcttatgatg cccagtttga ggtcataaaa ggacagacca tcgaagtccg ttgcgaatcg 1441 atcagtggaa ctttgcctat ttcttaccaa cttttaaaaa caagtaaagt tttggagaat 1501 agtaccaaga actcaaatga tcctgcggta ttcaaagaca accccactga agacgtcgaa 1561 taccagtgtg ttgcagataa ttgccattcc catgccaaaa tgttaagtga ggttctgagg 1621 gtgaaggtga tagccccggt ggatgaggtc cagatttcta tcctgtcaag taaggtggtg 1681 gagtctggag aggacattgt gctgcaatgt gctgtgaatg aaggatctgg tcccatcacc 1741 tataagtttt acagagaaaa agagggcaaa cccttctatc aaatgacctc aaatgccacc 1801 caggcatttt ggaccaagca gaaggctagc aaggaacagg agggagagta ttactgcaca 1861 gccttcaaca gagccaacca cgcctccagt gtccccagaa gcaaaatact gacagtcaga 1921 gtcattcttg ccccatggaa gaaaggactt attgcagtgg ttatcatcgg agtgatcatt 1981 gctctcttga tcattgcggc caaatgttat tttctgagga aagccaaggc caagcagatg 2041 ccagtggaaa tgtccaggcc agcagtacca cttctgaact ccaacaacga gaaaatgtca 2101 gatcccaata tggaagctaa cagtcattac ggtcacaatg acgatgtcag aaaccatgca 2161 atgaaaccaa taaatgataa taaagagcct ctgaactcag acgtgcagta cacggaagtt 2221 caagtgtcct cagctgagtc tcacaaagat ctaggaaaga aggacacaga gacagtgtac 2281 agtgaagtcc ggaaagctgt ccctgatgcc gtggaaagca gatactctag aacggaaggc 2341 tcccttgatg gaacttagac agcaaggcca gatgcacatc cctggaagga catccatgtt 2401 ccgagaagaa cagataatcc ctgtatttca agacctctgt gcacttattt atgaacctgc 2461 cctgctccca cagaacacag caattcctca ggctaagctg ccggttctta aatccatcct 2521 gctaagttaa tgttgggtag aaagagatac agagggg 1 cccgggttca agcgattctc ctgcctcagc ctcttgggta gctgggatta taggcgtgtg 61 ccaccgtgcc tggctaattt ttgtattttt attggagaca gggtttcacc atgttggcca 121 ggctggtctg aaactcctga cctcaggcaa tcctcctacc tcagcctctc aaagtgctgg 181 gattaccggc atgagccacg actcccggcc ccaaaggtca atcttaaagc tacaaggtat 241 cttttaaaag gagtaggaat aacgtatttt gaggcttaaa ggagtaggaa tagtgtattt 301 ttagatttga agccatcttc taaagggtac gatatttggt taacatgtca ctccttatcg 361 ccatggaaga agttaattct attctttttt tttttttttt gagatggagt ctcactctgt 421 tgcccaggct ggagtacaat ggtgtgatct cagctcactg caacctctgc ctcctgggtt 481 caagcaattc tcctgcctca gcctcctgag tagcagggat tacaggggtt ctccaccatg 541 cctgtctaat ttttgtattt ttttttttag tagaggtgga gtttcaccat gttggtcagg 601 ctggtctcaa acccctaacc tcatgatccg cccgccttgg cctcccaaag tgctgggatt 661 acaggcgtga gccaccatgc ccagccgtta attctattct tactgcttac tcccttattt 721 tgtatgttct tcttctatct tacatctttt gcttttgcta ttgcttaagc tagcctacgc 781 caagggtgct ctttgccccc tacttcctct gctattctcg cctcagttcc gctgcattcc 841 aagctcagcc tgccccagca gcaggtctct ttgacaaacc tgcaattttg gggaaaagtc 901 agccccaaga aaggcagggg gcccagactt atgctgtgtg gcaaaagccc tctttgatgg 961 gggaagggga ggactggaaa agcagagaga tctttctgga tgtcctggga gagcagccct 1021 ttgggtggtg ggtggaggct ggaggcaggg aggaatcccc tcacagtgcc atgagaaggg 1081 cccccaaacc caggcgagac agagggaggg tcaagaacgc caaggcaaat gtcacttgtg 1141 ccttgttttt tccctaaaga aactaaacaa agcggccgcg ttcggtggcc cctcaggaag 1201 gccggtcatt tcctgaggag atatcaggcc agcccaggcc ccattgttcc cggtttccag 1261 ccatggctgc cattacctga ccagcgccac agccggtctc tctgcaggcg ccgggagaag 1321 tgaccagagc aatttctgct tttcacaggg cgggtttctc aacggtgact tgtgggcagt 1381 gccttctgct gagcgagtca tggcccgaag gcagaactaa ctgtgcctgc agtcttcact 1441 ctcaggatgc agccgaggtg ggcccaaggg gccacgatgt ggcttggagt cctgctgacc 1501 cttctgctct gtgagtgttt actctgtttc cacatcactc taactccatg agcatcgaag 1 gaattccggg agaagtgacc agagcaattt ctgcttttca cagggcgggt ttctcaacgg 61 tgacttgtgg gcagtgcctt ctgctgagcg agtcatggcc cgaaggcaga actaactgtg 121 cctgcagtct tcactctcag gatgcagccg aggtgggccc aaggggccac gatgtggctt 181 ggagtcctgc tgacccttct gctctgttca agccttgagg gtcaagaaaa ctctttcaca 241 atcaacagtg ttgacatgaa gagcctgccg gactggacgg tgcaaaatgg gaagaacctg 301 accctgcagt gcttcgcgga tgtcagcacc acctctcacg tcaagcctca gcaccagatg 361 ctgttctata aggatgacgt gctgttttac aacatctcct ccatgaagag cacagagagt 421 tattttattc ctgaagtccg gatctatgac tcagggacat ataaatgtac tgtgattgtg 481 aacaacaaag agaaaaccac tgcagagtac cagctgttgg tggaaggagt gcccagtccc WO 00/09525 PCT/US99/17712 EPI-109 1048 541 agggtgacac tggacaagaaa agaggccatc caaggtggga tcgtgagggt caactgttct 601 gtcccagagg aaaaggcccc aatacacttc acaattgaaa aacttgaact aaatgaaaaa 661 atggtcaagc tgaaaagaga gaagaattct cgagaccaga attttgtgat actggaattc 721 cccgttgagg aacaggaccg cgttttatcc ttccgatgtc aagctaggat catttctggg 781 atccatatgc agacctcaga atctaccaag agtgaactgg tcaccgtgac ggaatccttc 841 tctacaccca agttccacat cagccccacc ggaatgatca tggaaggagc tcagctccac 901 attaagtgca ccattcaagt gactcacctg gcccaggagt ttccagaaat cataattcag 961 aaggacaagg cgattgtagc ccacaacaga catggcaaca aggctgtgta ctcagtcatg 1021 gccatggtgg agcacagtgg caactacacg tgcaaagtgg agtccagccg catatccaag 1081 gtcagcagca tcgtggtcaa cataacagaa ctattttcca agcccgaact ggaatcttcc 1141 ttcacacatc tggaccaagg tgaaagactg aacctgtcct gctccatccc aggagcacct 1201 ccagccaact tcaccatcca gaaggaagat acgattgtgt cacagactca agatttcacc 1261 aagatagcct caaagtcgga cagtgggacg tatatctgca ctgcaggtat tgacaaagtg 1321 gtcaagaaaa gcaacacaqt ccagatagtc gtatgtgaaa tgctctccca gcccaggatt 1381 tcttatgatg cccagtttga ggtcataaaa ggacagacca tcgaagtccg ttgcgaatcg 1441 atcagtggaa ctttgcctat ttcttaccaa cttttaaaaa caagtaaagt tttggagaat 1501 agtaccaaga actcaaatga tcctgcggta ttcaaagaca accccactga agacgtcgaa 1561 taccagtgtg ttgcagataa ttgccattcc catgccaaaa tgttaagtga ggttctgagg 1621 gtgaaggtga tagccccggt ggatgaggtc cagatttcta tcctgtcaag taaggtggtg 1681 gagtctggag aggacattgt gctgcaatgt gctgtgaatg aaggatctgg tcccatcacc 1741 tataagtttt acagagaaaa agagggcaaa cccttctatc aaatgacctc aaatgccacc 1801 caggcatttt ggaccaagca gaaggctagc aaggaacagg agggagagta ttactgcaca 1861 gccttcaaca gagccaacca cgcctccagt gtccccagaa gcaaaatact gacagtcaga 1921 gtcattcttg ccccatggaa gaaaggactt attgcagugg ttatcatcgg agtgatcatt 1981 gctctcttga tcattgcggc caaatgttat tttctgagga aagccaaggc caagcagatg 2041 ccagtggaaa tgtccaggcc agcagtacca cttctgaact ccaacaacga gaaaatgtca 2101 gatcccaata tggaagctaa cagtcattac ggtcacaatg acgatgtcag aaaccatgca 2161 atgaaaccaa taaatgataa taaagagcct ctgaactcag acgtgcagta cacggaagtt 2221 caagtgtcct cagctgagtc tcacaaagat ctaggaaaga aggacacaga gacagtgtac 2281 agtgaagtcc ggaaagctgt ccctgatgcc gtggaaagca gatactctag aacggaaggc 2341 tcccttgatg gaacttagac agcaaggcca gatgcacatc cctggaagga catccatgtt 2401 ccgagaagaa cagataatcc ctgtatttca agacctctgt gcacttattt atgaacctgc 2461 cctgctccca cagaacacag caattcctca ggctaagctg ccggttctta aatccatcct 2521 gctaagttaa tgttgggtag aaagagatac agagggg 1 tcttttggtt ttgctattgc ttaagctagc ctacgccaag ggtgctcttt gccccctact 61 tcctctgcta ttctcgcctc agttccgctg cattccaagc tcagcctgcc ccagcagcag 121 gtctctttga caaacctgca attttgggga aaagtcagcc caagaaaggc agggggccca 181 gacttatgct gtgtggcaaa agccctcttt gatggggcaa gggtaggact ggaaaagcag 241 agagatcttt ctggatgtcc tgggagagca gccctttggg tggtgggtgg aggctggagg 301 cagggaggaa tcccctcaca gtgagaaggg cccccaaacc caggcgagac agagggaggg 361 tcaagaacgc caaggcaaat gtcacttgtg ccttgttttt tccctaaaga aactaaacaa 421 agcggccgcg ttcggtggcc cctcaggaag gccggtcatt tcctgaggag atatcaggcc 481 agcccaggcc ccattgttcc cggtttccag ccatggctgc cattacctga ccagcgccac 541 agccggtctc tctgcaggcg ccgggagaag tgaccagagc aatttctgct tttcacaggg 601 cgggtttctc aacggtgact tgtgggcagt gccttctgct gagcgagtca tggcccgaag 661 gcagaactaa ctgtgcctgc agtcttcact ctcaggatgc agccgaggtg ggcccaaggg 721 gccacgatgt ggcttggagt cctgctgacc cttctgctct gtgagtgttt actctgtttc 781 cacatcactt taactccatg agcatcgaag cttctggaat caacatgttt cttatgtttc 841 ttgcaggttc aagccttgag ggtcaagaaa actgtaagtc tgatgtttcc actgtaacag 901 atgtttctac ctggcttcct cctttctctt ctgtgatgcc taaaacgcac attaaattgc 961 tggggtttga tacttctaac aattaaggaa aagaatccaa ttgagaacta aagtttatcc 1021 catgtgggca tttttagaaa ggcttagatc taagccaagt tctggtcagt gtgttttaga 1081 agtagcacac gtttccttgg ctggtctgaa agtagtgggt tatcttgatg aattgtttag 1141 tcagttacag atcaaactcc atgttctttt ctctgttctc acgactactc ttgactagtc 1201 taaaaatata ttaggttgtt gaaaagtaat tgtggttttt gccattactt tttaaaagat 1261 ggcaaaaaac acaattataa gtagcacaca ttttcttttt tttttccttt tttttttgag 1321 acagagtctc tgttacccag gctggagtgc agtggtgcaa tccggctctc tgcaaactcc 1381 gcctccaggg ttcaagggat tctcctgtct cagcctcctg ggtcgctgga attagagg 1 ttggcaggct ggtctcaaac tcctgacctc aggtgatccg ctggcctcca cctcccaaag 61 tgctgggatt acaggtgtga gccaccacgc ccggcctcac attttctaga tttcagtgca 121 ttgctgtttt ttgggatggg gaagtgattt ttttatttta atgagcaatt ccataattag 181 ttttttgttg ttttaccata atggcttatt tgaatattgt aaggtatccc caactgtttt 241 tatttgcaaa tgagatataa ttgatttgtt agacatatga agacagatcc tagtttaaat 301 tgttgctact ttttttactc ctaaatgata aaaatcacac actcgagctc 1 gctgtcccac agcccaccct tcatcacaat agtcctgaaa ctttttgggt tcagtaagga 61 aatctgtggg ccttctctcc agaaaaagca cacatttgca cacaattgga ggtagttgat 121 gagcctccta acacccaccc atgcacctcc caggggctgt gtcccccagg ttgtgaacag 181 tcactctgtg taaatagtga gacctacagg cagtaattca gtttggctgt gcttggctgg 241 tttatttaga aagatgataa tgttt 1 gagctctcca agggcagaca ctgccagcct cactgttct-c tgaaccccca gtatgggaca 61 gtgcttggca cagaaaaacc cccttaaatg tttgctatga atggtgctaa ggaagaaggc 121 agagaatgtc aaccagaggc caggcactgg caatatatac acggcccc WO 00/09525 PCT/US99/17712 EPI-109 1049 1 ataccttggc tcactgcaac ctctgcctcc caggttcaag cagttctcct gcctcagtct 61 cccaagtagc tgggattaca ggcgcccacc accacacccg gctaattttg tatttttagt 121 agagatgagg tttcaccatg ttggccaggc tggtcttgaa ctcctgacct caagtgatcc 181 acccgcctcg gcctcccaaa gtgctgggat tacaggcata aaccaccgtg cccggctggt 241 cca 1 gagctcatcc agcaggcttc ttaaatcagg agcttgtaag ttgcatataa agacaaaaaa 61 gggagttcca aagagtaatg ctgtgggaaa tgacttgaat ttaaaccgtc accttgtttg 121 atctcatgga ctggtcagac accatttttg ttgtcgttgt tgttgttaaa ttaattgctc 181 agaatatagc agcaggcgca aattgtagta ctcgttttaa aattgaagat taaattttaa 241 attacccaac aaaggcctaa ctttgttaaa ag 1 gaattctacc gacagcctat ggttactgga tataagccaa ttctgttctg gggacttgcc 61 agaaatgaca caattggcca gttgacccac agcctagttc ctagcagaga ttggatagct 121 gattgagcgt tgtggctgtt ttgaggcttg accagagatt cctgccgttg gcagagggga 181 atctgtagtc tttgcttctt ggtagcaggt gaggctgaaa acgcaagtag caggctaaaa 241 actggtttca agtcctcacc atctggtgaa acctcagagc ccatcagata gaaaatgcca 301 gctgggactg tgctaattcg gtaaggcctg ggtggagaag gagggcctgg gcacgaccat 361 ctggtttcgg aatggaggta gcagtcattt attaagtact taatgtatat cgggcactgt 421 acaggagacg ttctggctgt tctcctgtac atttcctgca aagacctaat gagatatgat 481 tactccatcc tacaggtaag gaaactgagc tcagagagtc tagctgccca gggtcacaca 541 gtaaatgatg agccaggact tgaacacttg actgcttgaa tcctgtactc cctccagggg 601 ccaagatgtg gcagctcaca gaatgcctat atcttttttt ttttttgtct tttgagacag 661 tctcactctg tagcccaggc tggagtgcag tggtgagatc tcacctcact gcaacccccg 721 cctcccaggt tcaagtgatt cttgtgcctc agcctctcaa gtagctgggt tacaggcctg 781 caccaccaaa cctggctaat ttttgtattt ttagtagaga gggggtttca ccatgttggc 841 caggccagtc tctaactgct gacctcaggt gatccaccca ccttggtctc ccaaagtgct 901 gggattatag gcgtgagcca ccatacctag ctctacatct ttatcactct gttcctttgc 961 cttggtggga aaagttgcag cttagtacca actgcctcct gcttgagcca ctgtgcacag 1021 ttactatcag cctggccctg taggcacgta gaacccctgg actcaatact gcataggatg 1081 ggataagacc acatctgatg ggtgaaggt caccgggatg atgttgttc tgagataaca 1141 ggtatgtctg ccttccttcg ggttgcattt agctttcaca atcaacagtg ttgacatgaa 1201 gagcctgccg gactggacgg tgcaaaatgg gaagaacctg accctgcagt gcttcgcgga 1261 tgtcagcacc acctctcacg tcaagcctca gcaccagatg ctgttctata aggatgacgt 1321 gctgttttac aacatctcct ccatgaagag cacagagagt tattttattc ctgaagtccg 1381 gatctatgac tcagggacat ataaatgtac tgtgattgtg aacaacaaag agaaaaccac 1441 tgcagagtac cagctgttgg tggaaggtga gtccttggaa ctgagcacag gcaagcagat 1501 ggagcatagc acacagtggc gtgaataaca gctgtgaatg aatagtgaca ctggacttaa 1561 ctctccaccc atcaccctct cattcatctg cctggcattt tccttacctg aatacgtaag 1621 cactagacat attccccaat aggcaggccc ttccttcctt ccttccttcc ttccttcctt 1681 ccttccttcc ttccttcctt ccttccttcc ttcctttctt tctttgatgg agtctcactc 1741 tgtcacccag tctggagtgc agtgggtgat ctcggctcac tgcaacctct gcctcccagg 1801 ttcaagcgat tctcctgcct cagcctccca agtaattggg attacaggtg tgtgccacca 1861 cacctggcta attttgtatt tttagtagag atggggtttc actgtgttgg tcaggctggt 1921 ctcgaactct gacctcaagt gatccacctg cctcccaaaa tgcttcttca tctcgctcta 1981 taaattacaa tttctttctt caagactcaa ctcaatgatg ttttgccaaa acaaaatggg 2041 tctaccccag ggtgccagt agtacagctc tgatgctctc tctacaggca atggtatttg 2101 tgtgtataaa ggccacagcg gtgtgttaag acacctcgtt ctgcagtcac tctgcctggg 2161 tttcaatctc gggtcaagtc cttaacatgc tctaaacttc aaaatcctca ccagtaaaag 2221 gaagataaca acgataccca tttcaggcaa ttattgagag ggtaaaagt gtcatgtggg 2281 tagagtgctt agcaaaattt ccagcaccta gtgagttcct aataaataga aatgtattta 2341 tttatttgag acagagtctt cctctgtcac ccaggctaaa gagcaaiggc gcgaccttgg 2401 ctcactgcaa cctctgtctc ctgggttcaa gcgattctcc tgtctcagcc tcccaagaaa 2461 ctgggattac aggcacgcgc cactgtgcct ggctaatttt ttgtattttt agtaaggatg 2521 gggttttacc atgttggcca gcctggtctc gaactcctaa cttcaagtga tttacccacc 2581 ttggcctccc agagtgtcag gattacaggt gtgagccacc atgcccggtc cacaaatatt 2641 ctatttcact cagtattggc atccgttctt acacatctgt ctgctcttct ggatagtgaa 2701 attgtaaaga cagagatggt gtttgggttt attcttatat cttgaacaat gaatctggct 2761 catagtaggc attcagtcaa tgttcatgga ataaattaaa gtcagtccta gcctgtgggt 2821 gcattcaata aagggtaaca acaatcacag tgacactgac aaatactggg ttacctttcc 2881 cctctaagca tcatctgttg ggaatctgat tgtgtcctct tcccaatagg attataaacc 2941 attgaaaaca ccaagtacat cttgaccata ttttattttt taaatttatt tatttattta 3001 tttatttatt tttagacaga gtctcactct gttgcccagg ctggagggca gtggcacgat 3061 ctcagctcac gcaacctct gccttcgggg ttcaagcaat tctcctgcct cagcctccaa 3121 gtagctggga tctacaggtgc ctgccaccat gccggctaat tttgatttaa tagagatggg 3181 gttcgccatg ttggccaggc tggtctcaaa ctcctgacct caggtgatcc acctgcctca 3241 gcctcccaaa gtgttgagat tacagatgtg agccacctcg cgtggcctta gtggtgattt 3301 tggtggaccc atcacccgag cagtgtacac tgtacccagt gtgtagtcat tttatccctc 3361 gctccctccc actctttccc ctgagtcccc aaagtccact gtatcact tatgcctttg 3421 tttcctcata gcttagctcc cattgagcat attttatatt ttttcctttc ttttcttctc 3481 ttttttgaga cagggtctct gttgcccagg ctggagtgca gtggtgggat tactgctcac 3541 tgccgcctca acctcctagg ctcaagtgat tctcccacct cggcctccca agtagctggg 3601 actaccagtg cacaccacta actacccctg gctaatttta attttttttt ttgtagagat 3661 agcatttcac cgtgttgccc aggctggtct ccaactcctg ggctcaagag atccacccac 3721 ctcagcctcc agattttata tatttcaaag tgcctagtac tgtgctgggc acatacctgt 3781 tcatttatta cctggtaggt cgcactgggt gtcagagaa caaaaaagag ccctctcatg 3841 ggatcaaccta cagtcactca gcggagggga gggcttgtgt ctctcaatca ggctgatact WO 00/09525 PCT/US99/17712 EPI-109 1050 3901 gacagacttt cttcttcaat caggctgata ctgacatgac tttctacttt ccccgtagga 3961 gtgcccagtc ccagggtgac actggacaag aaagaggcca tccaaggtgg gatcgtgagg 4021 gtcaactgtt ctgtcccaga ggaaaaggcc ccaatacact tcacaattga aaaacttgaa 4081 ctaaatgaaa aaatggtcaa gctgaaaaga gagaagaatt ctcgagacca gaattttgtg 4141 atactggaat tccccgttga ggaacaggac cgcgttttat ccttccgatg tcaagctagg 4201 atcatttctg ggatccatat gcagacctca gaatctacca agagtgaact ggtcaccgtg 4261 acgggtcagc atctgctccc ttcctcatcg ttctttgtgg tttctggt 1 gttctagaga agaaaggttg aattttaaag ttagttagga acaatagaaa agtttgaaaa 61 ggggaagcag caaaaagagc agaagaggct cctcttgccc aggtttgcac ctgagtccaa 121 ccaggttgtc ttcctctctt gcagaatcct tctctacacc caagttccac atcagcccca 181 ccggaatgat catggaagga gctcagctcc acattaagtg caccattcaa gtgactcacc 241 tggcccagga gtttccagaa atcataattc agaaggacaa ggcgattgtg gcccacaaca 301 gacatggcaa caaggctgtg tactcagtca tggccatggt ggagcacagt ggcaactaca 361 cgtgcaaagt ggagtccagc cgcatatcca aggtcagcag catcgtggtc aacataacag 421 gtagggctgc tgctgccgga gggtgttggc atatggcggg ctcaagaggc caccatgctg 481 caatccagca tggccaaaga gagctgatca tttcctgccc ctgcttatct gaatgaatgt 541 gctcagatgg ggctttggtg ctcgtgggag gaaaccactg cagagcgagt taacagtcta 601 ctgtgcgtgt tgagggtaca ggctccggca ccaaagctta accctgccgc tcactgcttc 661 tgtgaccttg ggtgagttat tgaacgtgcc gcagcgctgt gagatggtga taatgacctt 721 ttaggactgc tataatgatt aatgagataa ctatactgta agcatgagct gagagatttg 781 tacagagtaa gactctgaaa cactggttaa tgttttcatt actctgttat atttctccat 841 cccctgtgac aagcactatg ctagatc 1 gaattccggc ctgtgaatcc atctggttct tggacttttt ttggttggta agctattgat 61 tattgccaca atttcagatc ccgttattgg tctattcaga gattcaactt cttcctggtt 121 tagtcttggg agagtgtgtg tgttgaggaa tttatccatt tctcctagat tttctagttt 181 atttgcgtag aggtgtttgt agatattctc tgatggtagt ttgtatttgt gtgggatcgg 241 tgatgatatc ccctttatca ttttttattg cgtgtatttg attcttctct ctttttttct 301 ttattaggct tgctagcggt ctatcaattt tgttgatcct ttcaaaaaac cagctcctgg 361 attcattaat tttttgaagg gttttttgtg tctctatttc cttcagttct gctctgattt 421 tagttatttc ttgccttctg ctagcttaag gagtttcatt cttgttgccc aggctggagt 481 gcagtggagc aatctcggct cactgcaatc tctgtctcct gggttcaagg gattctcttg 541 cctcagcctc ccgagtatct gggattacag gcgcccacca ccatgctggc taattttata 601 tttttagtag agatggggtt tcaccatgtt gcccaggctg gtctcaactc ctgacctcag 661 gtgatccacc cacctctgcc tcccaaagtg ctgggattac aggcatgagc caccacacct 721 ggccacaagt tgcaaaactt ttctaatcct tgtcattgaa ataaattgga ttaacaagaa 781 aggaaaacct gccattggaa tcctaggcaa agaatgaacc ctagctcctt actggggtga 841 tcgttaggta catgagaagc aaaggaaaac tttttgctgg aagttggaag ttggttctgc 901 caagagcacc tgagccaagg gcctctccag gaagggtctt tagggtggtg gccagacaca 961 tctcgctcca ttcccactca ctgtttttca gaactatttt ccaagcccga actggaatct 1021 tccttcacac atctggacca aggtgaaaga ctgaacctgt cctgctccat cccaggagca 1081 cctccagcca acttcaccat ccagaaggaa gatacgattg tgtcacagac tcaagatttc 1141 accaagatag cctcaaagtc ggacagtggg acgtatatct gcactgcagg tattgacaaa 1201 gtggtcaaga aaagcaacac agtccagata gtcgtatgtg gtgagtatat tgttgcgact 1261 cagaggacat ccggggttga atgggagaaa ggaaatttat ctgcagctgc cgccctctcc 1321 ggtctccggt ctgagcagac tcaggcaggg taagaactag agggagagaa gtgcgaaatc 1381 aaaggccaaa gaaacaagga ggtattcctg ctcagaacac tgattcactg atgatgatgt 1441 ggcctctgac ttgcaagatt ctggcaagat tctgcctcct ggagcaagac ccacccaaaa 1501 gttcaggaag gaaacactac ttagtcaatg ttaaactttt cttttttttt tttgagacgt 1561 gtcgcccagg ctagagtgca gtggcacgat agctcactgc aacctctgcc tcctaggttc 1621 aagtgatctc ctgcctcagc ctcccaagta gctgggatta caggtgccca ccaccacgtc 1681 tgcctaattt ttgtattttt atttttatta cttttattta tttatttatt tatttttttt 1741 cggtctgtca cccaggctgg cagtgccagt ggcacaatct gggcatcact ggaaagcatc 1801 cgcactcctg ggtacacgag cattctcctg cctcagccct cccaagtggg tgtggactac 1861 aggacacaca gt 1 tcacttgagt ccaggagttc aagaccagcc tgagcacata gtgagaccct gtctctacaa 61 aaaataaaga attagccagg tgtggtgtgc acctatagtc ccagctactc gggaggctga 121 ggtaggagga ttgcttgatt ctgggaggtt gtagtgagct gtcatcgcac cagtgcactc 181 cagcctgggt aatagagtga gaccctgtct caaatacaca cacacacaca cacacacaca 241 cattttgttg gctacttgtt gtactttttc tatgttttct gtgtctttgc tcaacacaag 301 aaaagtatat tatgtgtgca tgtgcgtgtg agatatggta aaatatgaac atgtatttct 361 ggggatgtaa tgttttcctt gaatttctgt cattctctgt tttgcttatt gtacttctct 421 ttccctttcc cttctcacca cacacacaca cacacacaca cacacacaca cacagcctgt 481 cagtctcata ggtgtcctat aaaggtaaat ggcaggcagg catttgaaat tacagcaggg 541 atagaaagca aaactcaggc tttggaggag gaacctcttg tgctggatgc tttgttttta 601 ccttcagtgc cttttggatt gtttctccct ctgttctaga aagctctcc cagcccagga 661 tttcttatga tgcccagttt gaggtcataa aaggacagac catcgaagtc cgttgcgaat 721 cgatcagtgg aactttgcct atttcttacc aacttttaaa aacaagtaaa gttttggaga 781 atagtaccaa gaactcaaat gatcctgcgg tattcaaaga caaccccact gaagacgtcg 841 aataccagtg tgttgcagat aattgccatt cccacgccaa aatgttaagt gaggttctga 901 gggtgaaggt gataggtaag ttgctgtgct gtgagaagaa atcatgtggg cttggggcat 961 tctttcaccc ccagggactg tggggacaat aagagaagta gggggccagg tgcggtggct 1021 catgcctgta atcccagcac tttaggaggc caaggccggt gaatcattga ggccaggagt 1081 tcaagaccag cctggccaac atggtgaaac cccatctcta ctaaaaatac aaaaattagc 1141 tgggcatgat ggcgtgcgcc tataatccca gccactcggg aggctgaggc aggagaattg 1201 cttgaaccca ggaagcacag gttgcactga gccaagttgc gccattgcac tccagcctga WO 00/09525 PCTIUS99/17712 EPI-109 1051 1261 gcaacaagag cgaaactcca tctaaaaaaa aaaaagcgag agaagtagtg ggtgcttatg 1321 caaagtccat atactagata tgcaccaaag cagggccaag gttcagtaaa ggaggctgga 1381 aaatatttgg gggctattga tgaggacaat ataatctctt tccagaacct ttcaacaaac 1441 tgctaaaaga tgataagcat gaaagtgtcc tgactgcagg aagcactgaa gttgtgcata 1501 tgggcttccc tragcacttt ctccttttca gatacactgt tctgagaatt gtagatcagg 1561 actctgctgt tgtgactcct agccggggaa ccctgccttg tgtgaattcg agattagcct 1621 ggccaacatg gtgaaatcct gtctctaata aaaatacaaa aaattagctg ggtgtggtgg 1681 tgggcacctt taatgccagc tactcgggag gctgaggcac aagaatcatt tgaacctggg 1741 aggcagaggc tgcagtgagc caatatcatt ccgctacact ccagcctggg caacggagca 1801 agactccatc tcaaaaaaaa aaaaaattaa cattacatag actaagcacc taatggtgtg 1861 aggcatacaa aaaagaagac atattctttg tttcaatgct gtggtaagaa acacaagcc 1921 tcctaatgaa aatgatggac aaacatctga atcatactac caataagcat agaaaaaatg 1981 ttgggggtca tgtttggttg tcacgtgaac tatatcctta cagtgatggt gatagtaatt 2041 tagggtatgc cagacttcat ctagcttaag tgggtaaaca ttgtgaaaaa gctgggctag 2101 gtgccagggc ttgagaatgg gtggccagag aaggctgaag atggctgaac atctccagca 2161 aacacatgag ccaaaaggtc ccatggggca cttcaaaaga ctgtgcgcag ccaggtgcgg 2221 tggctcacgc ctataatccc agcactttgg gagaccgaat ggggtggatc acttgagccc 2281 agaggtttgt gactagcttg gccaacatgg caaaaccccg tctctactaa aaatacaaaa 2341 attagcccag cgtggtggtg ggtgtcctgt agccccagct actcaggtgg ctgaggtggt 2401 agaatcactt gaatccagga ggcagaggtt gcagtgagcc aagatcgtgc cactgcactc 2461 cagcctgggt gacagagtga gactctatct ccacaaaaaa aaaaaaaaaa aaaaaaatta 2521 aaggactgtg gccaaatcag atggctggaa acaaaggctg gagtttggga atggagaatc 2581 accggatatg agctgaaaaa gtggctgagc ctaagcgtga caggtgtcag gtgccagtct 2641 caggagtagg caattgtcct gcatgcagtg aaaagccaga agatggaagg aaggacagga 2701 tgcaaatgag ttctcggaac gatccacctg gtggctgggt cagggagcag gcatggtgac 2761 ttcagacctc atggtacgtt agaggctaat gtgaagccca tgtgaagctg ttggtttaaa 2821 ctgggtcgat atcagtggca cacatttact gaccatgtgt ccagccctgt gtgaagtact 2881 gtagtaaatt gctccaatgg aaactcacaa taaccacaga aggccagtaa cagcattgtc 2941 gttattttat catgacgcaa ctgaggctta gggcagacag ctggtgggtg gtgggactgg 3001 gatttgagcc cactggtgtc ccaggcccgg agcttggctt cttccattgt cttaccacag 3061 cctgcactca caggagagtg actcataagt tacaatacca tctgctgacc atctgctctc 3121 acactagaag gaaagtctac ttggggagac aatttaggat ccgaattttg gtagttgagg 3181 atggagctag gaaaagcgga tacaggaggt agccaagttc tgcttggacc tgcagggagt 3241 gaggctggcc gggctccagg tggaaatccc caggtgaaaa gggagacttg gagttcagga 3301 aagtaacctg gactggagcc ataggtttag gtgtcagtgg ctcagagaca gaagctcagc 3361 gtgtaggtga aatcacccag gaggagaatg gggatggaaa actgaggatt gaattttgca 3421 aaatgttcat acttccgggg aaaacaaaga ataaccagtg aataagaaag gggtgccagg 3481 taagaaggga agagaatcag agtcatgagg aaccccagaa ccccagaaaa agctgagttc 3541 cacgtaagac ctgggcaaca gtgaagtatg gagagcccaa gattgggagc gtggaggaag 3601 agcatccacc actgaattta atcagccccg gactcaggga cgttggttgg ggaatcaagt 3661 gaccttccca gtttcttcaa aacttgagag agagtgcagt gtcacaagat tgtgactaca 3721 aaagagtgca gtcagatttc aggggtaaca agaaagtgtg aaataaggga gtcaaagcat 3781 aaaggaaaaa ggagaaaaaa tggccgatag ctagagaagg cgtgggtcaa gattgtctgt 3841 ggcctggcat ggtggcttat gcctgtaatc ccagcatttt ggaaggccga ggtgggcaaa 3901 tcacctgagg tcaggaattc aagaccagcccggccaacag ggcaaaaccc cgtctctaaa 3961 acaacaacaa caacaaaaaa atccaaaaag ttagctgggc ctggtgggcg cacctgtcat 4021 tccagctact cgggaggctg aggcaggaga tttgcttgaa cccaggaggc acacgttgcg 4081 gtaagctgag attataccac tgcactccag cctgggtgat aagagcggga ctctgtctca 4141 gaggaaaaaa aaaaaagttg agcagtggct gtctcatgtt cctcttcctc tgcccttctt 4201 tgctcagtgt gaatcctttt cctgcttttc agccccggtg gatgaggtcc agatttctat 4261 cctgtcaagt aaggtggtgg agtctggaga ggacattgtg ctgcaatgtg ctgtgaatga 4321 aggatctggt cccatcacct ataagtttta cagagaaaaa gagggcaaac ccttctatca 4381 aatgacctca aatgccaccc aggcattttg gaccaagcag aaggctaaca aggaacagga 4441 gggagagtat tactgcacag ccttcaacag agccaaccac gcctccagtg tccccagaag 4501 caaaatactg acagtcagag gtgagtcagg gtctccatag caagctgtgc tgtgggcccc 4561 caagggcaag accagaaaac accccccttg taagagggag tttgggggga gtctagctta 4621 tgtgactgaa ggctaggaga gtaatgtcct ccaggctctt ggttgcaagt gacagaaacc 4681 cactcaaatt aagtaaaaaa gagaaatcga ttattataag gaattgggag aatgtcacat 4741 cgttccaatt acaaattgtt ggcagactca ccattgagtc atcttgggtc aaacatccaa 4801 ccacagacca cctgtagcca aggggattgg gtcacgcaga acagacatga ttggggaacc 4861 acttatgtgg gtgtgggggc ggtttcctgg agaagaagag ggctgaaaac acatgccaaa 4921 aaggagtcta ctccacttga gccctggagt tggagaccag cctgggcaac atggtgaaac 4981 cctgtctcta caaaaagtac aaaaataggc tgggcgcagt ggctcataec tgtaatccca 5041 gctactcggg aggctgagac atgagaatca cttgaaccca ggaggtagag gttgcagtga 5101 gcagagcttg ctccactgca ctccagcctg ggcaacagag caagactctg cctcaaaaat 5161 caaaccaaca aaaaatagct gtgtgtggtg gtgtgctcct gtagtcccag ctactcggga 5221 ggctgaggtg gaaggattgc tcaagcccag gaagttgagg ctgcagtgag ctgtcatcag 5281 cctctagcct gggtgacaga gtgagaccct gttcaaaaag aaagaaaaag aaaagagtct 5341 acccagcaaa gctggtttgt tccctccttg aggaccacag ctgacctcta tttgtagcag 5401 aaacaatcat ttctgcacca gctctgagtg cagaacccct cagaggtaga tggatgctaa 5461 ggcaagctgc cagttacaag agctgtgaga atcagactga cttttgttgc ttaaggcctg 5521 atattatttc ttcctggcag aggaagagcc tatatacaaa aaaaattttt tgttttgttt 5581 tgttttcagt cattcttgcc ccatggaaga aaggacttat tgcagtggtt atcatcggag 5641 tgatcattgc tctcttgatc attgcggcca aatgttat: tctgaggaaa gccaagggtg 5701 agcaagttc tttccttcca tactgactgg tccgtccttgc caggaaacca gccagggag WO 00/09525 PCT/US99/17712 EPI-109 1052 5761 cgtggtgctt ttctgacccc tggattcagc taggcaaaaa tgaaagctat tattttcctc 5821 attgggcaaa ccagaaaaga taaaatttgg gggaaattac atctttgtgt ggttagaaga 5881 agccatttct gtagatttgt ccacacctag tcctgtaatg cgtgtagagt ggggtgcaag 5941 cgtcttggag acacacaaac atgcgcataa cacccacatg ttgcacacac acattg 1 acctctttct tttctgtctt ttgaaaaaga gtgaatatat ttgccttctt tttctctctt 61 tttctgggta ttcaatcttc tgggaagtcc aaacgtagct gaaaagagtg ttccttcaca 121 gcttactagg agtaaaacaa aaagaaaaga aaagtgtttt ctatctatta ggttagtgca 181 aaagccattg gcgttttggc cattatagtg gtatggatgt gggtactgta tactgacttt 241 ggtttttcgt tttctgtttt taaagccaag cagatgccag tggaaatgtc caggtgagtg 301 tatttgtaag aagggggcgg ctgctctgtg agcacggtgg acargtctgg agggagattc 361 tggtcattag gaagttttca gtggctcttg gcaaacttag aaaaatatag gccttccttg 421 ggtgtgagtt gtgtgtgtga gttgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtatctc 481 cgtggaagaa tgccaattgt cctttcatgg gaaggaatgg cttttattct gagatcatgt 541 ccttcctaca tgattatttg tgaaatctcc ctttctttat gaaattataa tggtagtaga 601 taatttttta aaatttgaca aaatagagtt ggcctttaaa aaatggtttt actaccttta 661 ctgttgttga aatcccaaat caaaagtata gaaatgattg ctctgttcca gagagaaaca 721 gtagcgtggg ataagaattt cagggggctt ggtagtagcc tgtgaaggac tccggtattc 781 atgtgtgctt tggtctgatg ttatttaata ggaaagtt 1 aaaaaaaaaa aaagtttttt tacataatcc ttggagctgc caaaaaatat ttgttttcca 61 aatgagagag taaagttttc cttaccttgg aaaactcttc ctggttttct catgatcttc 121 ccttgtttac tttggtggtt tggggttaga acaataacaa caacaaatat atctatatat 181 tgttttctgt ttttatattt cattttaaag gccagcagta ccacttctga actccaacaa 241 cgagaaaatg tcagatccca atatggaagc taacagtcat tacggtaaag tcatgttctc 301 ctgccattta taattccccc caacttgcta catacttcct tacccctctc agaagcagaa 361 tatgtaagtg gtgggattac agttggaaga gaaaccctgg cttcaacagg gtacttcatc 421 tcatcagcca ctgggccatg taatatacgg aaacgtaaaa ggaaaggtaa catattttat 481 tctaactttg ccaccttcca aactccccgt agaagaaaga tggagaataa tcataatgcc 541 ttcaaagact ttgaacattg ctccagcgta atattataat tctccatttt caagacagag 601 acagatattg aatgaaacat tggtaaacat cttctcagat ggaattatta caagcacaag 661 acagttttac ttcaaatttg gcacaaaggg aaagcaattt caatattctc tcagtaaagg 721 cataaataaa gtgttccaac taagaaaata tctattcata aggctcatca gtagcttcag 781 ggtcagctca gctgaatgag taggcagtcc taggagttct taatcccagg ttagtaagaa 841 aattgctcaa gcatttcagc aggatgctac ttacttccca gaggggggta ttattacatc 901 acaaaaagtc ctgtcccaga ccaaatttgg ggacactctt cctctt atagccacga ctcaaatata ttgatcttag aatctaaaag acttaggtct gggcgcggtg 61 gctcacgcct gtaatctcaa cactttggga ggccgaggta ggtggatcac ttgaggtcag 121 cagttcaaaa accacctggc caacatggtg taaccctgtt tctactaaaa atacaaaaaa 181 ttagctgggc atggtggtag atgtttataa tcccagctac tcaggcaggc tgaggcagga 241 gaataccctt gaacctggga ggtggaggtt gcatgacctg a 1 tggacctcaa catgcacacc agtccgagca acaagagcga aactccatct caaaaaagaa 61 agaaagaaag aaactatatt caggccaggc atggtagttc atgcctataa ccccagctct 121 ttgggaggct gaggtgggag gatcattgag cccaggagtt ggagaccagc ctgtgcaaca 181 aagcgagaca tggagaatgt ggaacgaggg acccaggacc cagagacagt gctggttgtc 241 actacactga ataaatcagg cttgactttg ttaggggtac tgaattttta aaagggtttt 301 agaaaactag aatttccctt gtcactcacc ctaattgtta tttttcaact aggtcacaat 361 gacgatgtca gaaaccatgc aatgaaacca ataaatgata ataaaggtaa ttatctaatt 421 acatgttttt attagaacca acttttacat taaaaaaaag actcatagga aaagaaaact 481 aaaacttgaa ggactgtgga taatttccca cctctcttaa tgaccctgta cccagccgat 541 gtgtcaatga aggtagctag ctgctttcac cagagatgct atctagtgtc ctcagtggga 601 agtacctaaa tcaaagtagg gaagaactgg gttatactca aaaaa 1 acaacaactc tgtggtttct ttaggcagag cctctgaact cagacgtgca gtacacggaa 61 gttcaagtgt cctcagctga gtctcacaaa ggtaagtgcc actcgagtga gtccccaggc 121 attcgctttg gcttgggttt aaaccccagt ggtggcgggg gtgctgtgtt cagtgagaag 181 agtctgtgca ccctcagtcg ctccaaagga agtgattagc agacctaccg gcctgctaag 241 actggaagga gcaaggcccc tggcctggcc tgtctctgag ctgtaaaatt tcaataattt 301 aaaagaaaaa aagaaaaggc caggcactgt ggctcacacc tgtaatccta gcactttggg 361 aggccaaggc gggtggatca cctgagatca 1 tatattttat atattaatat ataaatataa atacatatat aatatataat atatgttttc 61 tttgtgtata atatatattt tataatattt tatatatttt tattttttat ttttatatat 121 tttatatata atatttttat atttatatta tttatatatt ttttatttta tatatatata 181 tatatttttt tttttctttg ttgagacgga gtctactctc tgcccaggct ggggtgcagt 241 tgcgagatct 1 tgcaaacctc tgcctccggg ttaaagcagc attctcctcc ctcagcctcc cgagtagctg 61 ggattacagg catgtcaccg ccacagccgg gtaatttatt tatttttttt ttgtattttt 121 aagtagagat gggatttcac catgttggcc agcgtgaact cgaacttctg acttcaaaag 181 atccaccccc ctcagcctcc caaagtgctg ggattacagg tgtgag 1 gaattcaatt tgagttttcc agacccgtcc tcctccttgg cagctaagga gcagtgtggg 61 aagtcaggcc tgagcctcag gtgttccctc tctgccttcc tgtgggtgga gagccaggta 121 ttaccaggta cgaaaagggg ctttgtgggt acaaggctca gtggtgagta catttgacct 181 ggtcttgacc aagccagttc cctgctctca agacttcctc ctcctatgga ggaggggttg 241 ggaaccacat ccagctctga ccctagtggc aggcgaccaa gtggtcactt ggggtggagg 301 aggggcagga aggaactcag taaatcctgg tttgctgcat gtttgctctg agactaattg 361 ctgggaaaac cccatgacgt tggaagccat ctccttctct gttatcacag agaaaaacag 421 aagccaaaat aaagccccat ccggaaacat ccctgacagc agagacaaag agcctgccag 481 cctggtttac tcattagcaa gcagctgctc cctggagtgg gtggggagga gaggtagtga WO 00/09525 PCTIUS99/17712 EPI-109 1053 541 tgagctgcaa ctctgcctgc ccacccatca cttaactggg cagatttggg ggcagctgca 601 actctagaag ctccaccaag aagcagaacc ccccaggccc aaacaccaag ccctctccct 661 ccatttattc ctcacctgcc ccagccccca ctgtgggcct gggtgggagg gtgagctggc 721 cgtgaccacc ccaccatgcg cctggtatat ggtgtttgat agcatttgtt gcagtgtctg 781 cgttgtttgt gcacctgtct gcctcacagc ctggagctcc tgaaagctgg ggaccaggcc 841 cgatcacctt tcctcttcca cagtgcgggg ttcacactag gtgtctagga ttctgctgag 901 tgagtgattt ggccaggcct gacatcaagc agagggtgtc ttggggatgt ggaggatccc 961 ccaatagggt tggggatccc tacagcttcc cttgagggcc ccacatctgg tgccacagaa 1021 agagagtgag gggtgtgtgg gcatctctgc tgtcccagca gtgtggtgcc ctggtagctc 1081 agccactcta ctgagttcca aatcctgttt gggtgccctg ggggaagtca gtgtaagggc 1141 ctagtca 1 aaggagggaa atccacttga ccatggcaca ggaacccccc ttacccaatc tgggccttcc 61 ctttccccca tctgtaaaag gagaacagtg cccacacgac atcagcctct tttcctacag 121 tgagccttcc tggccctttg tgcagtagac aggagctggg aagtgcccag gttccatcct 181 gtttcctcag ggttggtggg tatgtatgtg tgtgcacacc ctgtgtgcat gagtgtgtgc 241 acacccagat tgcatgtttg tacatacagt gtgtatacaa tgtgtgtaga cacatcctat 301 acactgtatg agggtataca tagcatgtat acacattgtg tgcatgagtg tgcgtgtgta 361 tatgctgtgt gtgtattttt gtatacacat cctgtgccca taccccagtg taaggtaaac 421 agatggcagg aagggcgccc ttgagtctcc tccaggtata cgccacaccc tgggtcagtc 481 atcatgctgc catattgaga gggtctagcc cagaggatct cagccctgtc tgcatattag 541 ggcccctgag gagatcctaa aaaaccagca ccagggaccc ccccagacca atccaaccag 601 aagctgcagt gaggcccagg agccagcagt gaaaacagcc agcccagctg tctatctctg 661 taagagttct cagtcccagc tattcctagg gtcactgaca acccccaggc tctaacccag 721 acctcaggat cttgttctgg atcccggggt ctgggctctc aggtgattgg gaggccatag 781 cccaaccctg cgttgaggga cctggcagaa tgtctggaca agggtcacgg tggcagggga 841 agaggagtgg gggcagcaag ctggaggctg caggcccttg ctggggggct ctccatccgt 901 gggcccctca ggtccagggg ttcctctggt gcatgtggcc ctgctccaca atggcctgct 961 gacctcctat tcccagactg ggagtgacgc tcgttagacc aagacctcct tcttcttctt 1021 cttttttttt tttgggaggt ggtgtgtcac tgtgttgccc aggctggagt gcagtggcgc 1081 aatcttggct cactgcaacc tctgcatcct gggttcaagc gattctcgtc ccttagctct 1141 cgagtaactg ggatcacagg gacgcaccac catgcccggt taattttttg gaatttttag 1201 tagagacggg gtttcggcat gttggccaga atggtctcaa cctcctgacc tcaagtgatc 1261 ttgccccctc aacctcccaa agtgctggga ttacaggtat gagccacctt gcccagccag 1321 gatcttctaa catcagaaat gacaaggtct ctgggtgctt ctggacctgg ttctggtggg 1381 gtgcagtggt ggggtacagc cttgcctgca gagcctcaga ccttttccta tgactgcagt 1441 ggactgacct cgttcccaga ggcagctact aacttatgcc tggtcctttt tccagatcta 1501 ggaaagaagg acacagagac agtgtacagt gaagtccgga aagctgtccc tggtgagtga 1561 gggtctccag tgccccagcc tgggggatgc cccctataat cactgatggg ggcttgggag 1621 tgggcagaga aaagaagaag caaagaaggg caaaaaaggg gtggcacctc ttacaccagc 1681 gctgtgggct tcctctctcc caccaccctt aaaaagtcac ctcgggtcac atttactatt 1741 catgtagtca acgagcgctt cttgaatgct tactgacccc agccggtgac ccttacctgc 1801 tccccacaca ggccctggtg gctggggttc cccaaggtct tggacgtcga gtgttttgct 1861 ttggagaccc ccagtagctt cagcctttct tcttgttttc ttttttctct tttttttttg 1921 gggatacgga gtctcgctct gtcactcagg ctggagtgca gtggtgcaat ctcgactcac 1981 tgcaacctcc acttcccgga tttaagtgat tctcctgcct cagcctccca agtagatggg 2041 attacaggcg cctgtcacca cactcagcta attttttttt tttatatttg ggagacagag 2101 tttcgctctt gatgcccagg ctggggtgca atggag 1 tgctgggatt accaagtgtg accccccgcc ccagcagctt cagcttttct gacaagaaga 61 ctgactttgg gagtgggtg gggtttgcgg atctactcta tttcctttgg ttcggctgcc 121 cccacttcgc ttcccgtgac gacccactgc ttactcatga aagggcttcc cccagagctg 181 agcacagagc ttaagcagac ccggaactgg gggagctcaa caagtccttt ttttcggtgg 241 gggggtataa taactgtatt caattcaggt gaaatgaaat acacaatgac aacttttaaa 301 ttctgaaggt aagtcagcaa tccgaaagac gtaaacattg tgggggaaat agtgactgtg 361 tgagtatctc gctttgtaca gcagacctct atttaagtgg gttcttggaa agggaatcat 421 taaaatggtc caggacattt ctgcaaaggg tgcctactca gcctaggcgt ggtggctcat 481 taagcactca gtaagtgctt tatttattta ccccaaataa ataaataaat ataaaaggat 541 gactcctccg agtacagtcg ccaaaccagc agcagcaatc tcgggcccag cccagaccca 601 caaaactagt ctctggaatc tgaacttagc cagcttcaga tgtttctgat gctgccaata 661 tttgagaagc actgtttgtg ttttgttttg tttttttgtt tgaaacagag tctcactctg 721 tcacccagac tggagtacag cagtgccatc tcagctgact gcaactccgt gcaacacccc 781 ccagccccta aggcttaagc gatcctccca agtagctaga accacagaca cacaccacca 841 tgcccagcta agtttttgta tttttggtag agatgaggtt ttaccatgtt gcccagactg 901 gtgttgaatt cctgagctca agcaatccac ccccttcggc ctcccaaagt gctgggatta 961 caagcgtgag ccactgtgcc aggcaaaaag cactgtttta gaagaaccat ccaattctct 1021 gaggaccctg ctttttatct gaaatagcga tcacttctta attcactttt aaaagttggt 1081 atatctacaa gaagaataga aactcaaccc ttgtggaact tgaccctgaa taatttttga 1141 aaaaccaatt ctctggggaa tttttagctc aaatacctca ttt 1 aaaaaaaaaa aaaaaaagaa gaagtagttt ctgcttttag tcagataaac aagctctggg 61 gagacttcct tctacatctg aaccagctca aaacaatcct tatgccaaag gggcatattt 121 tgtggtggca tattctgatt tccttcatct gctttagggc agctggctgt tcaagtgggt 181 tctctcgggg tctccaggtt ggttctaga 1 ctttctttct ttcctttctt tttttttttt ttgagacagg gtcttcgctc tgtcacccag 61 gctggagtgc agtggcgcga tcgcagctca ctgcaacctc cagctcccgg gttcaagtga 121 ttcttctgcc tcagcctcct gagtagctgg gaccacagct actgccacca cccccgggta 181 attttttttg tatttttagt agagacggtg tttcaccata ttggccaggc tgatctcgaa WO 00/09525 PCTUS99/17712 EPI-109 1054 241 ctccagacct caggtgatcc acctgccttg gcctcccaaa gtgctgggat aacaggtgtg 301 agacaccacg cccggccaga tcatat 1 gatcctatct acgggaaaca tgaagagtaa tattctactg tggcctgggt gaccctgggc 61 aagtcataga gcctctcaag accttggtca ccttctctgt gagatgaggt atgggctgga 121 ggcaggtcag tggtcctcgg gctttattaa aacatcaata gtttggcgca ccccactccc 181 tgtgaatttc ccattcacta ggtctggagc ggtgccgaaa acgtgcattt Ctaacaggtg 241 tccacacgca gctgctcgcc gacacgctgg ggcccgggct ttgagaacca ctcttgatgc 301 agcatgttcc tttctgattg tgccacgcta aggctctgct tcttgttgga aggagtaggg 361 tctttctcac cctccagaaa tcctggaggg atctttcagc attggtgggc aggtaaaacc 421 cagaaacact gtgcttatta gagggaaggt tgtattgagt gacccccaat aaaacagggg 481 gcccagggcc gcgcgcagtg gctcacgcct gtaatcccag caatttggga ggctaaggcg 541 ggcggatcat gaggtcagga gatcgagacc atcctggcta acacggtgga aaccccatct 601 ctactaaaaa tacaaaaaat tagctggacg tggt 1 agataagcaa tagggcatgg gcaggcctgc ctccaaggag cagccccagg gccgaggaga 61 gagagctggc gctggcccag gggacttgag tttgatggga aagcttgcag acagtggggg 121 agctgcctgg tctttccagt cttggctttt ggctctaagc acagcttttt tttttttttt 181 tttaattgtt gtatcatgag gcgccttcca ctcagctgcc tccccacgtt aggggatgga 241 cacagcactg gcagggatcc tgtgtgtctc agtttcccta ttgactctct gtggcctaga 301 gatgtatggt agaattccac actatgcttt ttttccaccg tgtttttttt tttttttttt 361 tttgagacag ggtctctctc tgtcacccag gctggagtgc agtggcgcaa tcttggctca 421 ctgcaacctc cacctcccca ggcaggcccc tctgactcag ctgggactac aggcatgcac 481 caccagcacc cagcaaaata tttttatatt ttagtagaga tggggtttcg tcacattggc 541 caggctggtc ttgaactcca gagctcaagc aatccgcccg cctcagcctc ccaaagtgct 601 gggattacaa tgcccagccc actttttttt ttacttttta caattttatt cttaaaattg 661 tggtaaaaca catatcacat aaaatttacc attttaactc taagtatcca gctcagtggc 721 actaagacta cacttttggt tgtcatagcg tggtgaacag agaagagaat gctactgcgt 781 ctcgtggaga gaggccaggg gataccgcta aacatgcgac aatgcacagg acagtcccct 841 ctccaccaca aaacaccacc cagcccaaaa cttcaacagg gccaccatgg agaaaccctg 901 gccagaggaa ttcacctcct gcaactcctc caacaggaga gctggttttc ctctccagta 961 ccagcttgtg gctgccctct gtcttgggag ggtgacttaa gggcacatcc cacctgatta 1021 ctgtgggctc tggatgggtg ctgagtcttg gtctggggaa cag 1 aaattaccca ggcatggtgg tgtgcgcctg tagtcccacc aacttgggag gctgaggcag 61 gagaattcct tgaatctggg aggcggaggg tgcagtgagc cgagatagtg ccagctgagg 121 caggagaatt ccctggaggt agaggttacg gtgagccaag atggcgccac cacactccag 181 cctgagtgac aaagcgagac tctgtctcaa aaaaaaaaaa ataaagaaaa ttttaaatga 241 agtgccaggg actttatgcg catgtcatgt ggagctagct acagggtccc ggggaagctg 301 tcttgcacaa aggagccata aacctctaag ggcactgccg gctgatgtct cctggctctc 361 gcctcctccc tcttttctcg acctgctcct gaccctgtga tgttgttggg gcagttgaac 421 tgggttattt gcgttgctca ctgccatgtc atcctttgtt ttgtagatgc cgtggaaagc 481 agatactctg taagtacaca tttcatatac attatattta aaagtactcc actgaacagt 541 gaaatatttc cagactcacc cacgcctgca ttcacacgaa ttcttccccg ctccctagcc 601 tgttcagacc agaagccctg ggcttctctg actagccttg gccagttctg atttcgaata 661 ttctctcctg caatttccat cattacatct cagcccacac gtgaagggat tgggactctg 721 gggtgcttag cgccaaacaa gcaaagcaca catttcgttt aacgccaaag tctaggctct 781 ggaagtgagg cagatctagg gtgtatgctt ggaggagtgg agcagctgac agctcattgc 841 aatttagccg atactaatta ccccctacac accaggccat cagctgcagg aggacaccca 901 agcttcttga cctcagttca ccttctgatg agggaatcag acatgtgatc acttatcata 961 aagccaagtg agctatgcca gagcctatgg gaacacagaa cagagaccta gctagtgccc 1021 tcttccccaa ggaatcattt ggaatggccc atgaagaatg aatggagtga tgatgccagc 1081 attgagggag aaagatcagc aggagcacaa gggtgaggga tgaccagttt caagcagtgt 1141 gggatgggaa agaagagtgt gacagtgaca agtgacggga gaaagataag tcagggctta 1201 aatccaaagg atttacatcc cttgttaaga agcttcattc tgtaggaaat ggagttagga 1261 atctgcattt ggcagatggg agggtttatg aaagacacag aggcccacgt tcaacttttg 1321 caaagacgtg tcttccaatc ccaacctttt tgtgagctac ccagcaatgc aggagttaac 1381 tgggcagcta atatctgaag aaatgaggca tttgccgcat aaacttcttt taggtctggg 1441 aagaactttc agcaaagatt tcaggtagct cttccagtgg cccctggctt cctttgtttt 1501 gcccatgtca ggactcttgt aaaacagagc tc 1 gagctccagc tttccagctg tcttttgggt gagcctgtct tcctcaagct caagcttcct 61 tatctataaa gtggagatgg tgatgacaat gatgataaga gcaacctatt aggattttaa 121 ggatgaaatg agcaactgca accaccatat aaaagctgca agctgcaaac caccatataa 181 aagctggttg atctcaagct cttttcatca cttgggcaat agtaggtgtg gatgggggac 241 ttaacttgat ttggccatga aatgaccctg ccacatatgg agaatgtagc agttgcttac 301 ccaaggcata ggattcaacc aaggccaggc tttgacttag gaatcagaga cccacattaa 361 catttgactt cccgcttctt agccatgtca ccatgggcaa atttcttggc ctctcaagac 421 ctctgcttcc taatctgtaa actgggaatc ataaactccc tcacttggtt gttgcaaggg 481 ttgaatgagc ac 1 ctatcaatct ccagagcttt ttctttttaa gtgtgagcga gtttattaga gaagtaaaga 61 gacccaagag tgcctactcc atagacagag cagccactgt gacactgtac ccattaaaca 121 ctaactctcc attgcccctc cagcaacccc tagcacccac tgtctacttt ctgtctctat 181 gtggttgtct atttgaggga catcacataa gtggagtcat atatttgtcc tttcatgtct 241 cccttatttc atttagcata acgttttcaa gggtttcctg tgttgtgaat atatcagaat 301 ttcattctct ttttaaggta gaatcatatc attttaaaac atttcagttg gaccatctaa 361 gttcagtcct tcattttcaa caattaaaaa acagccctca accgggcgca tctcacgtta 421 gctagagaca gaactggagc tagaagtcag atctcttacc aaagttgcct ttcttcttct 481 gtgggtaagt ggggcaccct tgggacgctg tgctgggcgt acatgggtgc ttgatgaagt WO 00/09525 PCT/US99/17712 EPI-109 1055 541 tacttggtgg actgatgtga ttgatgtcca acatgtatgc agggacagag gctatggtcc 601 ctacagagca ggcatggaga gaaggagaaa tacatacggg caggagccag gagagggagg 661 gtgtagtgag cagagaccgc gccactgcac tccagcctga gtgacagagt gagaatccat 721 ctaaaaaatt gcttactaaa gaagtggtct cctgaggtct taagacgttc ctggcaatgt 781 cttgagtggg tgggagagag cctccagtca ttgagctgtg gaatttcaga ggtgagaacc 841 acacctaacc cccaattact ttcccctgtt tgcctcagtg acacagctgc aggaaccctg 901 gtgggtgttg tattaagtaa atttgacctt tattctttgc agatctgtga aatgttgtct 961 tctgaggggc cacgtgtatc tgtagtgctg aggactcctt ggggcctctg aagtcacaga 1021 gagaacctgc agggtggggg accagtgtgt gacagccctg ctttgcattt tctttgagaa 1081 gtgctgtcat tttgcatttc tctccaccag gggaatcttc aatcttgaga ggtgtgatca 1141 taacttgcct tgtttcttgt cgctacagag aacggaaggc tcccttgatg gaacttagac 1201 agcaaggcca gatgcacatc cctggaagga catccatgtt ccgagaagaa cagatgatcc 1261 ctgtatttca agacctctgt gcacttattt atgaacctgc cctgctccca cagaacacag 1321 caattcctca ggctaagctg ccggttctta aatccatcct gctaagttaa tgttgggtag 1381 aaagagatac agaggggctg ttgaatttcc cacataccct ccttccacca agttggaaca 1441 tccttggaaa ttgggaagag cacaagagga gatccagggc aaggccattg ggatattctg 1501 aaacttgaat attttgtttt gtgcagagat aaagaccttt tccatgcacc ctcatacaca 1561 gaaaccaatt ttctttttta tactcaatca tttctagcgc atggcctggt tagaggctgg 1621 ttttttctct tttcctttgg tccttcaaag gcttgtagtt ttgggtagtc cttgttcttt 1681 ggaaatacac agtgctgacc agacagcctc cccctgtccc ctctatgacc tcgccctcca 1741 caaatgggaa aaccagacta cttgggagca ccgcctgtga aataccaacc tgaagacacg 1801 gttcattcag gcaacgcaca aaacagaaaa tgaaggtgga acaagcacat atgttcttca 1861 actgtttttg tctacactct ttctcttttc ctctacatgc tgaaggctga aagacaggaa 1921 agatggtgcc atcagcaaat attattctta attgaaaact tgaaatgtgt atgtttctta 1981 ctaattttta aaaatgtatt ccttgccagg gcaggcaagg tcgtcacgcc tgtaatccca 2041 gcacttcagg aggctgaggt gggcggatc 1 gaattccggg agaagtgacc agagcaattt ctgcttttca cagggcgggt ttctcaacgg 61 tgacttgtgg gcagtgcct ctgctgagcg agtcatggcc cgaaggcaga actaactgtg 121 cctgcagtct tcactctcag gatgcagccg aggtgggccc aaggggccac gatgtggctt 181 ggagtcctgc tgacccttct gctctgttca agccttgagg gtcaagaaaa ctctttcaca 241 atcaacagtg ttgacatgaa gagcctgccg gactggacgg tgcaaaatgg gaagaacctg 301 accctgcagt gcttcgcgga tgtcagcacc acctctcacg tcaagcctca gcaccagatg 361 ctgttctata aggatgacgt gctgttttac aacatctcct ccatgaagag cacagagagt 421 tattttattc ctgaagtccg gatctatgac tcagggacat ataaatgtac tgtgattgtg 481 aacaacaaag agaaaaccac tgcagagtac cagctgttgg tggaaggagt gcccagtccc 541 agggtgacac tggacaagaa agaggccatc caaggtggga tcgtgagggt caactgttct 601 gtcccagagg aaaaggcccc aatacacttc acaattgaaa aacttgaact aaatgaaaaa 661 atggtcaagc tgaaaagaga gaagaattct cgagaccaga attttgtgat actggaattc 721 cccgttgagg aacaggaccg cgttttatcc ttccgatgtc aagctaggat catttctggg 781 atccatatgc agacctcaga atctaccaag agtgaactgg tcaccgtgac ggaatccttc 841 tctacaccca agttccacat cagccccacc ggaatgatca tggaaggagc tcagctccac 901 attaagtgca ccattcaagt gactcacctg gcccaggagt ttccagaaat cataattcag 961 aaggacaagg cgattgtggc ccacaacaga catggcaaca aggctgtgta ctcagtcatg 1021 gccatggtgg agcacagtgg caactacacg tgcaaagtgg agtccagccg catatccaag 1081 gtcagcagca tcgtggtcaa cataacagaa ctattttcca agcccgaact ggaatcttcc 1141 ttcacacatc tggaccaagg tgaaagactg aacctgtcct gctccatccc aggagcacct 1201 ccagccaact tcaccatcca gaaggaagat acgattgtgt cacagactca agatttcacc 1261 aagatagcct caaagtcgga cagtgggacg tatatctgca ctgcaggtat tgacaaagtg 1321 gtcaagaaaa gcaacacagt ccagatagtc gtatgtgaaa tgctctccca gcccaggatt 1381 tcttatgatg cccagtttga ggtcataaaa ggacagacca tcgaagtccg ttgcgaatcg 1441 atcagtggaa ctttgcctat ttcttaccaa cttttaaaaa caagtaaagt tttggagaat 1501 agtaccaaga actcaaatga tcctgcggta ttcaaagaca accccactga agacgtcgaa 1561 taccagtgtg ttgcagataa ttgccattcc catgccaaaa tgttaagtga ggttctgagg 1621 gtgaaggtga tagccccggt ggatgaggtc cagatttcta tcctgtcaag taaggtggtg 1681 gagtctggag aggacattgt gctgcaatgt gctgtgaatg aaggatctgg tcccatcacc 1741 tataagtttt acagagaaaa agagggcaaa cccttctatc aaatgacctc aaatgccacc 1801 caggcatttt ggaccaagca gaaggctagc aaggaacagg agggagagta ttactgcaca 1861 gccttcaaca gagccaacca cgcctccagt gtccccagaa gcaaaatact gacagtcaga 1921 gtcattcttg ccccatggaa gaaaggactt attgcagtgg ttatcatcgg agtgatcatt 1981 gctctcttga tcattgcggc caaatgttat tttctgagga aagccaaggc caagcagatg 2041 ccagtggaaa tgtccaggcc agcagtacca cttctgaact ccaacaacga gaaaatgtca 2101 gatcccaata tggaagctaa cagtcattac ggtcacaatg acgatgtcag aaaccatgca 2161 atgaaaccaa taaatgataa taaagagcct ctgaactcag acgtgcagta cacggaagtt 2221 caagtgtcct cagctgagtc tcacaaagat ctaggaaaga aggacacaga gacagtgtac 2281 agtgaagtcc ggaaagctgt ccctgatgcc gtggaaagca gatactctag aacggaaggc 2341 tcccttgatg gaacttagac agcaaggcca gatgcacatc cctggaagga catccatgtt 2401 ccgagaagaa cagataatcc ctgtatttca agacctctgt gcacttattt atgaacctgc 2461 cctgctccca cagaacacag caattcctca ggctaagctg ccggttctta aatccatcct 2521 gctaagttaa tgttgggtag aaagagatac agagggg (2) INFORMATION FOR SEQ ID NO:2789: WO 00/09525 PCT/US99/17712 EPI-109 1056 (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2789 1 tggtcatctc agtttctttt ctcaccttga ctgcaagatg aaactccttg tgctagctgt 61 gctgctcaca gtggccgccg ccgacagcgg catcagccct cgggccgtgt ggcagttccg 121 caaaatgatc aagtgcgtga tcccggggag tgaccccttc ttggaataca acaactacgg 181 ctgctactgt ggcttggggg gctcaggcac ccccgtggat gaactggaca agtgctgcca 241 gacacatgac aactgctatg accaggccaa gaagctggac agctgtaaat ttctgctgga 301 caacccgtac acccacacct attcatactc gtgctctggc tcggcaatca cctgtagcag 361 caaaaacaaa gagtgtgagg ccttcatttg caactgcgac cgcaacgctg ccatctgctt 421 ttcaaaagct ccatataaca aggcacacaa gaacctggac accaagaagt attgtcagag 481 ttgaatatca cctctcaaaa gcatcacctc tatctgcctc atctcacact gtactctcca 541 ataaagcacc ttgttgaaag aa (2) INFORMATION FOR SEQ ID NO:2790: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2790 1 ctgcagaggc tcaatcactg ttcattgcag ccttgacctc cctggctcac gagatcctcc 61 catctcagcc tcctgagttg ctgggatcac aggtgcaatc caccaccaca cctggttaac 121 attttttttt ttagagatga ggtctctcta tgttgcccag gctgcacttc cttcttgtct 181 cccttatccc agcgtccgac tgaactgacg gctttgcttt ccccaaccag cccgtgaagc 241 tgggctgagt acaaagtggt gggtatgagg gtcaaqattg taagatctga aaactccaga 301 aaccatccct ttggttaaca gttgctaagg acaaatgcat aacatatttt ccagtgatcc 361 catgctggca aatcgtgagg gtcattcctg caacagacag attcaaggcc agccccaaac 421 tcagccaaga gcaaagcaaa cactccagcc ttatctgggc agggttgtgt ggagactgac 481 tataagacta tacctgagac tggtcatctc agttcttttc tcaccttgac tgcaagatga 541 aactccttgt gctagctgtg ctgctcacag gtaggcaagt ctccccggct ccacccgcct 601 ttctctccca agtgagctaa gatctcactc ctctggaatg ggggccacac acagcaaaca 661 gggatggcca gccccgcagt ctcaattcga ggttcccagt gggcttaagg gctcctctat 721 tggggttccc tcaaggctgg cactttttca acctgcaagt ctgaactcag attgcctgag 781 ctaagaaagc ttgcctttat tttctttttt ccagacaggg tcttgctcta taacccaggc 841 tggagttcag tggcatgatc atagctcacc acagcttcca actcgtgggc tcaagtgatc 901 ctcccacctt actcaactaa gtagttaggc caatctccca tttattttat tttattttaa 961 tttttatttt tattttactt tattttattt ttgagacggg gctcactctg tcgccaggct 1021 ggagtgcggt gggctgatct cagatcacta caacctccat ctcctggttc aaataattct 1081 cttgcctcag cctctcaag.t agctggactt gtagctctca agtagctggc acacaccacc 1141 atgcccagct aattttttgt gtgttttttt tggtagagac aggttttcac catgttggcc 1201 aggctgggtg acctcccttt tagattctcc tcatcctgct ctattcttcc cctttctaaa 1261 tgcagtatcc agtttcctta cttatacact ttattattat tcttattatt attgagacag 1321 agtcttgctt tgtgcccaag gctggagtac agtggtgcga tctcggctca ctgcaagctc 1381 cacctgctgg gttcacgcca ttctcccgcc tcagcctccc cagtagctgg gactaaagcg 1441 cctgccacca cgccccgcta atttttttgt atttttaata aagacggggt ttcatcgtgt 1501 tagccaggat ggtctcgatc tcatgacctt gtgatccgcc tgcctcggcc tcccaaatgc 1561 tggattacag gcatgagcca ccgtgcccgg ccttatcaca tttattattt attgtttttc 1621 tctcccacta ggttgtaagc tccatgaggt tagagattat tattattatt attattatta 1681 ttattattat tattattatt attatatctg ttcactgctg tatctctagc tcctaggaca 1741 gagcctggca catagtaagt gctcaataaa tattcactgg ataaacagtg cagatagttt 1801 aaaactatct gacctaggga ggctgaggca ggagaatggc gtgaacccgg gaagcagagt 1861 ttgcagtgag ctgaaatcgt gtcactgcac tccaacctgg gcaacagagc aagactccat 1921 ctcaaaaaaa aaaaaaaaac tatcaggcct agctgggtgg cacatgcctg taatcctagc 1981 tgaggcggta gggtcccaga agaagaagaa gaagaaaaag aagaagatat atatatatat 2041 acacacacac aaagatataa actttatata tataaagttt tcattaaaaa aaaaaaaaac 2101 ctctacccac tttcacttta ccaggttcct gggtccaacg gtcttcagag gaggcagctg 2161 gcaggggtca gggaggcagc gtgggacccg agggagcagg aaggcagtgt gtccccgggg 2221 tgctggcaga ccgatttgaa ctctggctat gtcttcttgc agtggccgcc gccgacagcg 2281 gcatcagccc tcgggccgtg tggcagttcc gcaaaatgat caagtgcgtg atcccgggga 2341 gtgacccctt cttggaatac aacaactacg gctgctactg tggcttgggg ggctcaggca 2401 cccccgtgga tgaactggac aagtaagtga tccgcctgca ggaaaattgg agtgcctgcc 2461 gggggcgggg tggggcacca cgccaaggat ctcacgaggc atacaaaggg gacttgcata 2521 tctgctaagg ataacatatt ttcacctctt gtcaaataaa catatatgtt ccaagaggac 2581 cctgtagcga acgcaccccg ttagagatgg aaacattgac cgacgtgcaa aacagtgggc 2641 gatgctgccc tccagtggca gaatgtagca acattaaaca tcacagcacc tatccacgtg WO 00/09525 PCT/US99/17712 EPI-109 1057 2701 tcattttcta gcagtggttg tcactgcccc ttctggaata caggatttta ctgtattctt 2761 gcaaccatgt taaaaatcgc tttcaggcca ggcgcggtgg ctcatgcctg taatcccagc 2821 actttgggag gccgaggcgg gcggatcact tgaggtcagg agttcgagac cagcctggcc 2881 aacatggtga aaccctgtct ctactaaaaa atacaaaaat tagccggaca tggtggcgag 2941 cgcctgtaac cccagctact tgggagactg agttggaggt ttcatgagcc aaggtcgtgt 3001 cactgctgtc cagcctgggt aacagagcaa ctctgtctca aaaaaaaaaa atgctttcaa 3061 taaatatatg ataaaaggac ttatattttt tcaagccata ggatcatttc tcctgaagca 3121 tcttggcgaa gtcatcccca cctgttcctg agagtgggca ggtgagggct gacctattgc 3181 tctgcactta ctcctatctc agctgtccct cccactttcc aggtgctgcc agacacatga 3241 caactgctac gaccaggcca agaagctgga cagctgtaaa tttctgctgg acaacccgta 3301 cacccacacc tattcatact cgtgctctgg ctcggcaatc acctgtagca gtaggtttat 3361 cccttccttg accta (2) INFORMATION FOR SEQ ID NO:2791: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2791 1 gcccactccc accgccagct ggaaccctgg ggactacgac gtccctcaaa ccttgcttct 61 aggagataaa aagaacatcc agtcatggat aaaaatgagc tggttcagaa ggccaaactg 121 gccgagcagg ctgagcgata tgatgacatg gcagcctgca tgaagtctgt aactgagcaa 181 ggagctgaat tatccaatga ggagaggaat cttctctcag ttgcttataa aaatgttgta 241 ggagcccgta ggtcatctt' gagggtcgtc tcaagtattq aacaaaagac ggaaggtgct 301 gagaaaaaac agcagatggc tcgagaatac agagagaaaa ttgagacgga gctaagagat 361 atctgcaatg atgtactgtc tcttttggaa aagttcttga tccccaatgc ttcacaagca 421 gagagcaaag tcttctattt gaaaatgaaa ggagattact accgttactt ggctgaggtt 481 gccgctggtg atgacaagaa agggattgtc gatcagtcac aacaagcata ccaagaagct 541 tttgaaatca gcaaaaagga aatgcaacca acacatccta tcagactggg tctggccctt 601 aacttctctg tgttctatta tgagattctg aactccccag agaaagcctg ctctcttgca 661 aagacagctt ttgatgaagc cattgctgaa cttgatacat taagtgaaga gtcatacaaa 721 gacagcacgc taataatgca attactgaga gacaacttga cattgtggac atcggatacc 781 caaggagacg aagctgaagc aggagaagga ggggaaaatt aaccggcctt ccaacttttg 841 tctgcctcat tctaaaattt acacagtaga ccatttgtca tccatgctgt cccacaaata 901 gttttttgtt tacgatttat gacaggttta tgttacttct atttgaattt ctatatttcc 961 catgtggttt ttatgtttaa tattagggga gtagagccag ttaacattta gggagttatc 1021 tgttttcatc ttgaggtggc caatatgggg atgtggaatt tttatacaag ttataagtgt 1081 ttggcatagt acttttggta cattgtggct tcaaaagggc cagtgtaaaa ctgcttccat 1141 gtctaagcaa agaaaactgc ctacatactg gtttgtcctg gcggggaata aaagggatca 1201 ttggttccag tcacaggtgt agtaattgtg ggtactttaa ggtttggagc acttacaagg 1261 ctgtggtaga atcatacccc atggatacca catattaaac catgtatatc tgtggaatac 1321 tcaatgtgta cacctttgac tacagctgca gaagtgttcc tttagacaaa gttgtgaccc 1381 attttactct ggataagggc agaaacggtt cacattccat tatttgtaaa gttacctgct 1441 gttagctttc attatttttg ctacactcat tttatttgta tttaaatgtt ttaggcaacc 1501 taagaacaaa tgtaaaagta aagatgcagg aaaaatgaat tgcttggtat tcattacttc 1561 atgtatatca agcacagcag taaaacaaaa acccatgtat ttaacttttt tttaggattt 1621 ttgcttttgt gatttttttt tttttttttt gatacttgcc taacatgcat gtgctgtaaa 1681 aatagttaac agggaaataa cttgagatga tggctagctt tgtttaatgt cttatgaaat 1741 tttcatgaac aatccaagcA taattgttaa gaacacgtgt attaaattca tgtaagtgga 1801 ataaaagttt tatgaatgga cttttcaact actttctcta cagcttttca tgtaaattag 1861 tcttggttct gaaacttctc taaaggaaat tgtacattct ttgaaattta ttccttattc 1921 cctcttggca gctaatgggc tcttaccaag tttaaacaca aaatttatca taacaaaaat 1981 actactaata taactactgt ttccatgtcc catgatcccc tctcttcctc cccaccctga 2041 aaaaaatgag ttcctatttt ttctgggaga gggggggatt gattagaaaa aaatgtagtg 2101 tgttccattt aaaattttgg catatggcat tttctaactt aggaagccac aatgttcttg 2161 gcccatcatg acattgggta gcattaactg taagttttgt gcttccaaat cactttttgg 2221 tttttaagaa tttcttgata ctcttatagc ctgccttcaa ttttgatcct ttattctttc 2281 tatttgtcag gtgcacaaga ttaccttcct gttttagcct tctgtcttgt caccaaccat 2341 tcttacttgg tggccatgta cttggaaaaa ggccgcatga tctttctggc tccactcagt 2401 gtctaaggca ccctgcttcc tttgcttgca tcccacagac tatttccctc atcctattta 2461 ctgcagcaaa tctctcctta gttgatgaga ctgtgtttat ctccctttaa aaccctacct 2521 atcctgaatg gtctgtcatt gtctgccttt aaaatccttc ctctttcttc ctcctctatt 2581 ctctaaataa tgatggggct aagttatacc caaagctcac tttacaaaat atttcctcag 2641 tactttgcag aaaacaccaa acaaaaatgc cattttaaaa aaggtgtatt ttttctttta 2701 gaatgtaagc tcctcaagag cagggacaat gttttctgta tgttctattg tgcctagtac 2761 actgtaaatg ctcaataaat attgatgatg ggaggcagtg agtcttgatg ataagggtga 2821 gaaactgaaa tccc WO 00/09525 PCT/US99/17712 EPI-109 1058 (2) INFORMATION FOR SEQ ID NO:2792: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2792 1 tggtcatctc agtttctttt ctcaccttga ctgcaagatg aaactccttg tgctagctgt 61 gctgctcaca gtggccgccg ccgacagcgg catcagccct cgggccgtgt ggcagttccg 121 caaaatgatc aagtgcgtga tcccggggag tgaccccttc ttggaataca acaactacgg 181 ctgctactgt ggcttggggg gctcaggcac ccccgtggat gaactggaca agtgctgcca 241 gacacatgac aactgctatg accaggccaa gaagctggac agctgtaaat ttctgctgga 301 caacccgtac acccacacct attcatactc gtgctctggc tcggcaatca cctgtagcag 361 caaaaacaaa gagtgtgagg ccttcatttg caactgcgac cgcaacgctg ccatctgctt 421 ttcaaaagct ccatataaca aggcacacaa gaacctggac accaagaagt attgtcagag 481 ttgaatatca cctctcaaaa gcatcacctc tatctgcctc atctcacact gtactctcca 541 ataaagcacc ttgttgaaag aa 1 ctgcagaggc tcaatcactg ttcattgcag ccttgacctc cctggctcac gagatcctcc 61 catctcagcc tcctgagttg ctgggatcac aggtgcaatc caccaccaca cctggttaac 121 attttttttt ttagagatga ggtctctcta tgttgcccag gctgcacttc cttcttgtct 181 cccttatccc agcgtccgac tgaactgacg gctttgcttt ccccaaccag cccgtgaagc 241 tgggctgagt acaaagtggt gggtatgagg gtcaagattg taagatctga aaactccaga 301 aaccatccct ttggttaaca gttgctaagg acaaatgcat aacatatttt ccagtgatcc 361 catgctggca aatcgtgagg gtcattcctg caacagacag attcaaggcc agccccaaac 421 tcagccaaga gcaaagcaaa cactccagcc ttatctgggc agggttgtgt ggagactgac 481 tataagacta tacctgagac tggtcatctc agttcttttc tcaccttgac tgcaagatga 541 aactccttgt gctagctgtg ctgctcacag gtaggcaagt ctccccggct ccacccgcct 601 ttctctccca agtgagctaa gatctcactc ctctggaatg ggggccacac acagcaaaca 661 gggatggcca gccccgcagt ctcaattcga ggttcccagt gggcttaagg gctcctctat 721 tggggttccc tcaaggctgg cactttttca acctgcaagt ctgaactcag attgcctgag 781 ctaagaaagc ttgcctttat tttctttttt ccagacaggg tcttgctcta taacccaggc 841 tggagttcag tggcatgatc atagctcacc acagcttcca actcgtgggc tcaagtgatc 901 ctcccacctt actcaactaa gtagttaggc caatctccca tttattttat tttattttaa 961 tttttatttt tattttactt tattttattt ttgagacggg gctcactctg tcgccaggct 1021 ggagtgcggt gggctgatct cagatcacta caacctccat ctcctggttc aaataattct 1081 cttgcctcag cctctcaagt agctggactt gtagctctca agtagctggc acacaccacc 1141 atgcccagct aattttttgt gtgttttttt tggtagagac aggttttcac catgttggcc 1201 aggctgggtg acctcccttt tagattctcc tcatcctgct ctattcttcc cctttctaaa 1261 tgcagtatcc agtttcctta cttatacact ttattattat tcttattatt attgagacag 1321 agtcttgctt tgtgcccaag gctggagtac agtggtgcga tctcggctca ctgcaagctc 1381 cacctgctgg gttcacgcca ttctcccgcc tcagcctccc cagtagctgg gactaaagcg 1441 cctgccacca cgccccgcta atttttttgt atttttaata aagacggggt ttcatcgtgt 1501 tagccaggat ggtctcgatc tcatgacctt gtgatccgcc tgcctcggcc tcccaaatgc 1561 tggattacag gcatgagcca ccgtgcccgg ccttatcaca tttattattt attgtttttc 1621 tctcccacta ggttgtaagc tccatgaggt tagagattat tattattatt attattatta 1681 ttattattat tattattatt attatatctg ttcactgctg tatctctagc tcctaggaca 1741 gagcctggca catagtaagt gctcaataaa tattcactgg ataaacagtg cagatagttt 1801 aaaactatct gacctaggga ggctgaggca ggagaatggc gtgaacccgg gaagcagagt 1861 ttgcagtgag ctgaaatcgt gtcactgcac tccaacctgg gcaacagagc aagactccat 1921 ctcaaaaaaa aaaaaaaaac tatcaggcct agctgggtgg cacatgcctg taatcctagc 1981 tgaggcggta gggtcccaga agaagaagaa gaagaaaaag aagaagatat atatatatat 2041 acacacacac aaagatataa actttatata tataaagttt tcattaaaaa aaaaaaaaac 2101 ctctacccac tttcacttta ccaggttcct gggtccaacg gtcttcagag gaggcagctg 2161 gcaggggtca gggaggcagc gtgggacccg agggagcagg aaggcagtgt gtccccgggg 2221 tgctggcaga ccgatttgaa ctctggctat gtcttcttgc agtggccgcc gccgacagcg 2281 gcatcagccc tcgggccgtg tggcagttcc gcaaaatgat caagtgcgtg atcccgggga 2341 gtgacccctt cttggaatac aacaactacg gctgctactg tggcttgggg ggctcaggca 2401 cccccgtgga tgaactggac aagtaagtga tccgcctgca ggaaaattgg agtgcctgcc 2461 gggggcgggg tggggcacca cgccaaggat ctcacgaggc atacaaaggg gacttgcata 2521 tctgctaagg ataacatatt ttcacctctt gtcaaataaa catatatgtt ccaagaggac 2581 cctgtagcga acgcaccccg ttagagatgg aaacattgac cgacgtgcaa aacagtgggc 2641 gatgctgccc tccagtggca gaatgtagca acattaaaca tcacagcacc tatccacgtg 2701 tcattttcta gcagtggttg tcactgcccc ttctggaata caggatttta ctgtattctt 2761 gcaaccatgt taaaaatcgc tttcaggcca ggcgcggtgg ctcatgcctg taatcccagc 2821 actttgggag gccgaggcgg gcggatcact tgaggtcagg agttcgagac cagcctggcc 2881 aacatggtga aaccctgtct ctactaaaaa atacaaaaat tagccggaca tggtggcgag 2941 cgcctgtaac cccagctact tgggagactg agttggaggt ttcatgagcc aaggtcgtgt 3001 cactgctgtc cagcctgggt aacagagcaa ctctgtctca aaaaaaaaaa atgctttcaa 3061 taaatatatg ataaaaggac ttatattttt caagccata ggatcatttc tcctgaagca WO 00/09525 PCT/US99/17712 EPI-109 1059 3121 tcttggcgaa gtcatcccca cctgttcctg agagtgggca ggtgagggct gacctattgc 3181 tctgcacta ctcctatctc agctgtccct cccactttcc aggtgctgcc agacacatga 3241 caactgctac gaccaggcca agaagctgga cagctgtaaa tttctgctgg acaacccgta 3301 cacccacacc tattcatact cgtgctctgg ctcggcaatc acctgtagca gtaggtttat 3361 cccttccttg accta 1 gcccactccc accgccagct ggaaccctgg ggactacgac gtccctcaaa ccttgcttct 61 aggagataaa aagaacatcc agtcatggat aaaaatgagc tggttcagaa ggccaaactg 121 gccgagcagg ctgagcgata tgatgacatg gcagcctgca tgaagtctgt aactgagcaa 181 ggagctgaat tatccaatga ggagaggaat cttctctcag ttgcttataa aaatgttgta 241 ggagcccgta ggtcatcttg gagggtcgtc tcaagtattg aacaaaagac ggaaggtgct 301 gagaaaaaac agcagatggc tcgagaatac agagagaaaa ttgagacgga gctaagagat 361 atctgcaatg atgtactgtc tcttttggaa aagttcttga tccccaatgc ttcacaagca 421 gagagcaaag tcttctattt gaaaatgaaa ggagattact accgttactt ggctgaggtt 481 gccgctggtg atgacaagaa agggattgtc gatcagtcac aacaagcata ccaagaagct 541 tttgaaatca gcaaaaaaga aatgcaacca acacatccta tcagactggg tctggccctt 601 aacttctctg tgttctatta tgagattctg aactccccag agaaagcctg ctctcttgca 661 aagacagctt ttgatgaagc cattgctgaa cttgatacat taagtgaaga gtcatacaaa 721 gacagcacgc taataatgca attactgaga gacaacttga cattgtggac atcggatacc 781 caaggagacg aagctgaagc aggagaagga ggggaaaatt aaccggcctt ccaacttttg 841 tctgcctcat tctaaaattt acacagtaga ccatttgtca tccatgctgt cccacaaata 901 gttttttgtt tacgatttat gacaggttta tgttacttct atttgaattt ctatatttcc 961 catgtggttt ttatgtttaa tattagggga gtagagccag ttaacattta gggagttatc 1021 tgttttcatc ttgaggtggc caatatgggg atgtggaatt tttatacaag ttataagtgt 1081 ttggcatagt acttttggta cattgtggct tcaaaagggc cagtgtaaaa ctgcttccat 1141 gtctaagcaa agaaaactgc ctacatactg gtttgtcctg gcggggaata aaagggatca 1201 ttggttccag tcacaggtgt agtaattgtg ggtactttaa ggtttggagc acttacaagg 1261 ctgtggtaga atcatacccc atggatacca catattaaac catgtatatc tgtggaatac 1321 tcaatgtgta cacctttgac tacagctgca gaagtgttcc tttagacaaa gttgtgaccc 1381 attttactct ggataagggc agaaacggtt cacattccat tatttgtaaa gttacctgct 1441 gttagctttc attatttttg ctacactcat tttatttgta tttaaatgtt ttaggcaacc 1501 taagaacaaa tgtaaaagta aagatgcagg aaaaatgaat tgcttggtat tcattacttc 1561 atgtatatca agcacagcag taaaacaaaa acccatgtat ttaacttttt tttaggattt 1621 ttgcttttgt gatttttttt tttttttttt gatacttgcc taacatgcat gtgctgtaaa 1681 aatagttaac agggaaataa cttgagatga tggctagctt tgtttaatgt cttatgaaat 1741 tttcatgaac aatccaagca taattgttaa gaacacgtgt attaaattca tgtaagtgga 1801 ataaaagttt tatgaatgga cttttcaact actttctcta cagcttttca tgtaaattag 1861 tcttggttct gaaacttctc taaaggaaat tgtacattct ttgaaattta ttccttattc 1921 cctcttggca gctaatgggc tcttaccaag tttaaacaca aaatttatca taacaaaaat 1981 actactaata taactactgt ttccatgtcc catgatcccc tctcttcctc cccaccctga 2041 aaaaaatgag ttcctatttt ttctgggaga gggggggatt gattagaaaa aaatgtagtg 2101 tgttccattt aaaattttgg catatggcat tttctaactt aggaagccac aatgttcttg 2161 gcccatcatg acattgggta gcattaactg taagttttgt gcttccaaat cactttttgg 2221 tttttaagaa tttcttgata ctcttatagc ctgccttcaa ttttgatcct ttattctttc 2281 tatttgtcag gtgcacaaga ttaccttcct gttttagcct tctgtcttgt caccaaccat 2341 tcttacttgg tggccatgta cttggaaaaa ggccgcataa tctttctggc tccactcagt 2401 gtctaaggca ccctgcttcc tttgcttgca tcccacagac tatttccctc atcctattta 2461 ctgcagcaaa tctctcctta gttgatgaga ctgtgtttat ctccctttaa aaccctacct 2521 atcctgaatg gtctgtcatt gtctgccttt aaaatccttc ctctttcttc ctcctctatt 2581 ctctaaataa tgatggggct aagttatacc caaagctcac tttacaaaat atttcctcag 2641 tactttgcag aaaacaccaa acaaaaatgc cattttaaaa aaggtgtatt ttttctttta 2701 gaatgtaagc tcctcaagag cagggacaat gttttctgta tgttctattg tgcctagtac 2761 actgtaaatg ctcaataaat attgatgatg ggaggcagtq agtcttgatg ataagggtga 2821 gaaactgaaa tccc (2) INFORMATION FOR SEQ ID NO:2793: (1) SEQUENCE CHARACTERISTICS: (A) LENGTH: _base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2793 1 gctgtgcaac ctcggcgcca tgcgcaacct ctatgcgata caccggcggc tgcagcggca 61 cccgcgctcc tgcaccaggg actgtgccga gccgcgcgca gacgggaggg aagcgtcccc 121 tcagcccctg gaggagctgg atcacctcct gctgctggcg ctgatgaccg tgctcttcac 181 tatgtgttct ctgcccgtaa tttatcgcgc ttactatgga gcatttaagg atgtcaagga 241 gaaaaacagg acctctgaag aagcagaaga cctccgagcc ttgcgatttc tatctgtgat 301 ttcaattgtg gacccttgga tttttatcat tttcagatct ccagtatttc ggatattttt 361 tcacaagatt ttcattagac ctcttaggta caggagccag tgcagcaatt ccactaacat 421 ggaatccagt ctgtgacagt gtttttcact ctgtggtaag ctgaggaata tgtcacattt WO 00/09525 PCT/US99/17712 EPI-109 1060 481 tcagtcaaag aacca (2) INFORMATION FOR SEQ ID NO:2794: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2794 1 gaattctggc tattttcctc ctgccgttcc gactcggcac cagagtctgt ctctactgag 61 aacgcagcgc gtcagggccg agctcttcac tggcctgctc cgcgctcttc aatgccagcg 121 ccaggcgctc accctgcaga gcgtcccgcc tctcaaagag gggtgtgacc cgcgagttta 181 gataggaggt tcctgccgtg gggaacaccc cgccgccctc ggagcttttt ctgtggcgca 241 gcttctccgc ccgagccgcg cgcggagctg ccgggggctc cttagcaccc gggcgccggg 301 gccctcgccc ttccgcagcc ttcactccag ccctctgctc ccgcacgcca tgaagtcgcc 361 gttctaccgc tgccagaaca ccacctctgt ggaaaaaggc aactcggcgg tgatgggcgg 421 ggtgctcttc agcaccggcc tcctgggcaa cctgctggcc ctggggctgc tggcgcgctc 481 ggggctgggg tggtgctcgc ggcgtccact gcgcccgctg ccctcggtct tctacatgct 541 ggtgtgtggc ctgacggtca ccgacttgct gggcaagtgc ctcctaagcc cggtggtgct 601 ggctgcctac gctcagaacc ggagtctgcg ggtgcttgcg cccgcattgg acaactcgtt 661 gtgccaagcc ttcgccttct tcatgtcctt ctttgggctc tcctcgacac tgcaactcct 721 ggccatggca ctggagtgct ggctctccct agggcaccct ttcttctacc gacggcacat 781 caccctgcgc ctgggcgcac tggtggcccc ggtggtgagc gccttctccc tggctttctg 841 cgcgctacct ttcatgggct tcgggaagtt cgtgcagtac tgccccggca cctggtgctt 901 tatccagatg gtccacgagg agggctcgct gtcggtgctg gggtactctg tgctctactc 961 cagcctcatg gcgctgctgg tcctcgccac cgtgctgtgc aacctcggcg ccatgcgcaa 1021 cctctatgcg atgcaccggc ggctgcagcg gcacccgcgc tcctgcacca gggactgtgc 1081 cgagccgcgc gcggacggga gggaagcgtc ccctcagccc ctggaggagc tggatcacct 1141 cctgctgctg gcgctgatga ccgtgctctt cactatgtgt tctctgcccg taattgtgag 1201 tccccgggcc ccgagg (2) INFORMATION FOR SEQ ID NO:2795: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: _base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2795 1 gggccgccgt cggcgcgctg ggtgcgggaa gggggctctg gatttcggtc cctccccttt 61 ttcctctgag tctcggaacg ctccagctct cagaccctct tcctcccagg taaaggccgg 121 gagaggaggg cgcatctctt ttccaggcac cccaccatgg gcaatgcctc caatgactcc 181 cagtctgagg actgcgagac gcgacagtgg cttcccccag gcgaaagccc agccatcagc 241 tccgtcatgt tctcggccgg ggtgctgggg aacctcatag cactggcgct gctggcgcgc 301 cgctggcggg gggacgtggg gtgcagcgcc ggccgcagga gctccctctc cttgttccac 361 gtgctggtga ccgagctggt gttcaccgac ctgctcggga cctgcctcat cagcccagtg 421 gtactggctt cgtacgcgcg gaaccagacc ctggtggcac tggcgcccga gagccgcgcg 481 tgcacctact tcgctttcgc catgaccttc ttcagcctgg ccacgatgct catgctcttc 541 gccatggccc tggagcgcta cctctcgatc gggcacccct acttctacca gcgccgcgtc 601 tcggcctccg ggggcctggc cgtgctgcct gtcatctatg cagtctccct gctcttctgc 661 tcgctgccgc tgctggacta tgggcagtac gtccagtact gccccgggac ctggtgcttc 721 atccggcacg ggcggaccgc ttacctgcag ctgtacgcca ccctgctgct gcttctcatt 781 gtctcggtgc tcgcctgcaa cttcagtgtc attctcaacc tcatccgcat gcaccgccga 841 agccggagaa gccgctgcgg accttccctg ggcagtggcc ggggcggccc cggggcccgc 901 aggagagggg aaagggtgtc catggcggag gagacggacc acctcattct cctggctatc 961 atgaccatca ccttcgccgt ctgctccttg cctttcacga tttttgcata tatgaatgaa 1021 acctcttccc gaaaggaaaa atgggacctc caagctctta ggtttttatc aattaattca 1081 ataattgacc cttgggtctt tgccatcctt aggcctcctg ttctgagact aatgcgttca 1141 gtcctctgtt gtcggatttc attaagaaca caagatgcaa cacaaacttc ctgttctaca 1201 cagtcagatg ccagtaaaca ggctgacctt tgaggtcagt agtttaaaag ttcttagtta 1261 tatagcatct ggaagatcat tttgaaattg ttccctggag aaatgaaaac agtgtgtaaa 1321 caaaatgaag ctgccctaat aaaaaggagt atacaaacat ttaagctgtg gtcaaggcta 1381 cagatgtgct gacaaggcac ttcatgtaaa gtgtcagaag gagctacaaa acctaccctc 1441 aatgagcatg gtacttggcc tttggaggaa caatcggctg cattgaagatc ccagctgcct 1501 attgatttaa gctttcctgt tgaatgacaa agtatgtggt tttgtaattt gtttgaaacc 1561 ccaaacagtg actgtacttt ctattttaat cttgctacta ccgttataca catatagtgt 1621 acagccagac cagattaaac ttcatatgta atctctagga agtcaatatg tggaagcaac 1681 caagcctgct gtcttgtgat cacttagcga accctttatt tgaacaatcga agttgaaaat 1741 cataggcacc ttttactgtg atgtttgtgt atgtgggagt actctcatca ctacagtatt 1801 actcttacaa gagtggactc agtgggttaa catcagtttt gctactcat cctccaggaa WO 00/09525 PCT/US99/17712 EPI-109 1061 1861 ctgcaggtca agttgtcagg ttatttattt tataatgtcc atatgctaat agtgatcaag 1921 aagactttag gaatggttct ctcaacaaga aataatagaa atgtctcaag gcagttaatt 1981 ctcattaata ctcttattat cctatttctg ggggaggatg tacgtggcca tgtatgaagc 2041 caaatattag gcttaaaaac tgaaaaatct ggttcattct tcagatatac tggaaccctt 2101 ttaaagttga tattggggcc atgagtaaaa tagattttat aagatgactg tgttgtacca 2161 aaattcatct gtctatattt tatttagggg aacatggttt gactcatctt atatgggaaa 2221 ccatgtagca gtgagtcata tcttaatata tttctaaatg tttggcatgt aaatgtaaac 2281 tcagcatcaa aatatttcag tgaatttgca ctgtttaatc atagttactg tgtaaactca 2341 tctgaaatgt tacaaaaata aactataaaa ca (2) INFORMATION FOR SEQ ID NO:2796: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2796 1 agagaggaag gcgtggctcc ctcccgggcc agtgagccct ggcgccgccg cggccgcggt 61 cccagcagcg gagtagggcg gcggctgcgc cccgcaccat ggggggcagc ccagccccag 121 ccgcggtaaa cgccgacctc cgccgccgcc cgcgccgcgt ctgccccctc ccgctgcggc 181 tctctggacg ccatcccctc ctcacctcga agccaacatg aaggagaccc ggggctacgg 241 aggggatgcc cccttctgca cccgcctcaa ccactcctac acaggcatgt gggcgcccga 301 gcgttccgcc gaggcgcggg gcaacctcac gcgccctcca gggtctggcg aggattgcgg 361 atcggtgtcc gtggccttcc cgatcaccat gctgctcact ggtttcgtgg gcaacgcact 421 ggccatgctg ctcgtgtcgc gcagctaccg gcgccgggag agcaagcgca agaagtcctt 481 cctgctgtgc atcggctggc tggcgctcac cgacctggtc gggcagcttc tcaccacccc 541 ggtcgtcatc gtcgtgtacc tgtccaagca gcgttgggag cacatcgacc cgtcggggcg 601 gctctgcacc tttttcgggc tgaccatgac tgttttcggg ctctcctcgt tgttcatcgc 661 cagcgccatg gccgtcgagc gggcgctggc catcagggcg ccgcactggt atgcgagcca 721 catgaagacg cgtgccaccc gcgctgtgct gctcggcgtg tggctggccg tgctcgcctt 781 cgccctgctg ccggtgctgg gcgtgggcca gtacaccgtc cagtggcccg ggacgtggtg 841 cttcatcagc accgggcgag ggggcaacgg gactagctct tcgcataact ggggcaacct 901 tttcttcgcc tctgcctttg ccttcctggg gctcttggcg ctgacagtca ccttttcctg 961 caacctggcc accattaagg ccctggtgtc ccgctgccgg gccaaggcca cggcatctca 1021 gtccagtgcc cagtggggcc gcatcacgac cgagacggcc attcagctta tggggatcat 1081 gtgcgtgctg tcggtctgct ggtctccgct cctgataatg atgttgaaaa tgatcttcaa 1141 tcagacatca gttgagcact gcaagacaca cacggagaag cagaaagaat gcaacttctt 1201 cttaatagct gttcgcctgg cttcactgaa ccagatcttg gatccttggg tttacctgct 1261 gttaagaaag atccttcttc gaaagttttg ccaggtagca aatgctgtct ccagctgctc 1321 taatgatgga cagaaagggc agcctatctc attatctaat gaaataatac agacagaagc 1381 atgaaagaaa acacttaact tgcatgtgca cagcttctgg taacaaatat cgctaaacct 1441 tactgtgaat ttaggcatct ctggcatgcc actgtttatg cattgaagtg gaatttttgg 1501 tataaagcta aatggtctta gaagcataga aaatccctat gtgccaaaag tagtgaaaca 1561 caaacaaagg aaaatatatt aataacagtc tagtgttttt gttgagtctg ccattcgtag 1621 ctgaatatgt gattaattat gtgatgaaaa ctttttttat aaatgatctt ggtctattgg 1681 gg (2) INFORMATION FOR SEQ ID NO:2797: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: _base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2797 1 cccgggccag tgagccctgg cgccgccgcg gccgcggtcc cagcagcgga gtagggcggc 61 ggctgcgccc cgcaccatgg ggggcagccc agccccagcc gcggtaaacg ccgacctccg 121 ccgccgcccg cgccgcgtct gccccctccc gctgcggctc tctggacgcc atcccctcct 181 cacctcgaag ccaacatgaa ggagacccgg ggctacggag gggatgcccc cttctgcacc 241 cgcctcaacc actcctacac aggcatgtgg gcgcccgagc gttccgccga ggcgcggggc 301 aacctcacgc gccctccagg gtctggcgag gattgcggat cggtgtccgt ggccttcccg 361 atcaccatgc tgctcactgg tttcgtgggc aacgcactgg ccatgctgct cgtgtcgcgc 421 agctaccggc gccgggagag caagcgcaag aagtccttcc tgctgtgcat cggctggctg 481 gcgctcaccg acctggtcgg gcagcttctc accaccccgg tcgtcatcgt cgtgtacctg 541 tccaagcagc gttgggagca catcgacccg tcggggcggc tctgcacctt tttcgggctg 601 accatgactg ttttcgggct ctcctcgttg ttcatcgcca gcgccatggc cgtcgagcgg 661 gcgctggcca tcagggcgcc gcactggtat gcgagccaca tgaagacgcg tgccacccgc 721 gctgtgctgc tcggcgtgtg gctgqccgtg ctcgccttcg ccctgctgcc ggtgctgggc 781 gtgggccagt acaccgtcca gtggcccggg acgtggtgct tcatcagcac cgggcgaggg 841 ggcaacggga ctagctcttc gcataactgg ggcaaccttt tcttcgcctc tgcctttgcc WO 00/09525 PCT/US99/17712 EPI-109 1062 901 ttcctggggc tcttggcgct gacagtcacc ttttcctgca acctggccac cattaaggcc 961 ctggtgtccc gctgccgggc caaggccacg gcatctcagt ccagtgccca gtggggccgc 1021 atcacgaccg agacggccat tcagcttatg gggatcatgt gcgtgctgtc ggtctgctgg 1081 tctccgctcc tgataatgat gttgaaaatg atcttcaatc agacatcagt tgagcactgc 1141 aagacacaca cggagaagca gaaagaatgc aacttcttct taatagctgt tcgcctggct 1201 tcactgaacc agatcttgga tccttgggtt tacctgctgt taagaaagat ccttcttcga 1261 aagttttgcc agatcaggta ccacacaaac aactatgcat ccagctccac ctccttaccc 1321 tgccagtgtt cctcaacctt gatgtggagc gaccatttgg aaagataatg aaagaacgga 1381 gttggacatt ttattgcaat tcctgcttcc ctgaatttgc atatttcttc ccacctgaga 1441 aggataatta tatattttaa tttggattat ttcttcattt ttatcttttt attttaatga 1501 ttgttttgtc agtaataccc atggagatca actttattat tataatccat gcctctgaat 1561 attagattgg tttcttggat gggattttga atatgcattt aagaagttgg gaagaatttc 1621 acagatgatg attggaggaa aagtgatgaa aagaaagacc tgtgttccag gagttttctc 1681 caacttcaaa cctttacgtg aatcttaacc aaagtggaca tctttacatt tcatgatagc 1741 ttgcttttgc aatatgagtt tgaaaaatca gtataagctt atgatggtga aaagtcaaca 1801 tattgagagt gataattcaa ttaataggat atgaacttaa cgatataaaa gcaaatgagg 1861 gcaggagggg (2) INFORMATION FOR SEQ ID NO:2798: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2798 1 agagaggaag gcgtggctcc ctcccgggcc agtgagccct ggcgccgccg cggccgcggt 61 cccagcagcg gagtagggcg gcggctgcgc cccgcaccat ggggggcagc ccagccccag 121 ccgcggtaaa cgccgacctc cgccgccgcc cgcgccgcgt ctgccccctc ccgctgcggc 181 tctctggacg ccatcccctc ctcacctcga agccaacatg aaggagaccc ggggctacgg 241 aggggatgcc cccttctgca cccgcctcaa ccactcctac acaggcatgt gggcgcccga 301 gcgttccgcc gaggcgcggg gcaacctcac gcgccctcca gggtctggcg aggattgcgg 361 atcggtgtcc gtggccttcc cgatcaccat gctgctcact ggtttcgtgg gcaacgcact 421 ggccatgctg ctcgtgtcgc gcagctaccg gcgccgggag agcaagcgca agaagtcctt 481 cctgctgtgc atcggctggc tggcgctcac cgacctggtc gggcagcttc tcaccacccc 541 ggtcgtcatc gtcgtgtacc tgtccaagca gcgttgggag cacatcgacc cgtcggggcg 601 gctctgcacc tttttcgggc tgaccatgac tgttttcggg ctctcctcgt tgttcatcgc 661 cagcgccatg gccgtcgagc gggcgctggc catcagggcg ccgcactggt atgcgagcca 721 catgaagacg cgtgccaccc gcgctgtgct gctcggcgtg tggctggccg tgctcgcctt 781 cgccctgctg ccggtgctgg gcgtgggcca gtacaccgtc cagtggcccg ggacgtggtg 841 cttcatcagc accgggcgag ggggcaacgg gactagctct tcgcataact ggggcaacct 901 tttcttcgcc tctgcctttg ccttcctggg gctcttggcg ctgacagtca ccttttcctg 961 caacctggcc accattaagg ccctggtgtc ccgctgccgg gccaaggcca cggcatctca 1021 gtccagtgcc cagtggggcc gcatcacgac cgagacggcc attcagctta tggggatcat 1081 gtgcgtgctg tcggtctgct ggtctccgct cctgataatg atgttgaaaa tgatcttcaa 1141 tcagacatca gttgagcact gcaagacaca cacggagaag cagaaagaat gcaacttctt 1201 cttaatagct gttcgcctgg cttcactgaa ccagatcttg gatccttggg tttacctgct 1261 gttaagaaag atccttcttc gaaagttttg ccaggtagca aatgctgtct ccagctgctc 1321 taatgatgga cagaaagggc agcctatctc attatctaat gaaataatac agacagaagc 1381 atgaaagaaa acacttaact tgcatgtgca cagcttctgg taacaaatat cgctaaacct 1441 tactgtgaat ttaggcatct ctggcatgcc actgtttatg cattgaagtg gaatttttgg 1501 tataaagcta aatggtctta gaagcataga aaatccctat gtgccaaaag tagtgaaaca 1561 caaacaaagg aaaatatatt aataacagtc tagtgttttt gttgagtctg ccattcgtag 1621 ctgaatatgt gattaattat gtgatgaaaa ctttttttat aaatgatctt ggtctattgg 1681 gg (2) INFORMATION FOR SEQ ID NO:2799: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: _base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single g(D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2799 1 agagaggaag gcgtggctcc ctcccgggcc agtgagccct ggcgccgccg cggccgcggt 61 cccagcagcg gagtagggcg gcggctgcgc cccgcaccat ggggggcagc ccagccccag 121 ccgcggtaaa cgccgacctc cgccgccgcc cgcgccgcgt ctgccccctc ccgctgcggc 181 tctctggacg ccatcccctc ctcacctcga agccaacatg aaggagaccc ggggctacgg 241 aggggatgcc cccttctgca cccgcctcaa ccactcctac acaggcatgt gggcgcccga 301 gcgttccgcc gaggcgcggg gcaacctcac gcgccctcca gggtctggcg aggattgcgg 361 atcggtgtcc gtggccttcc cgatcaccat gctgctcact ggtttcgtgg gcaacgcact WO 00/09525 PCT/US99/17712 EPI-109 1063 421 ggccatgctg ctcgtgtcgc gcagctaccg gcgccgggag agcaagcgca agaagtcctt 481 cctgctgtgc atcggctggc tggcgctcac cgacctggtc gggcagcttc tcaccacccc 541 ggtcgtcatc gtcgtgtacc tgtccaagca gcgttgggag cacatcgacc cgtcggggcg 601 gctctgcacc tttttcgggc tgaccatgac tgttttcggg ctctcctcgt tgttcatcgc 661 cagcgccatg gccgtcgagc gggcgctggc catcagggcg ccgcactggt atgcgagcca 721 catgaagacg cgtgccaccc gcgctgtgct gctcggcgtg tggctggccg tgctcgcctt 781 cgccctgctg ccggtgctgg gcgtgggcca gtacaccgtc cagtggcccg ggacgtggtg 841 cttcatcagc accgggcgag ggggcaacgg gactagctct tcgcataact ggggcaacct 901 tttcttcgcc tctgcctttg ccttcctggg gctcttggcg ctgacagtca ccttttcctg 961 caacctggcc accattaagg ccctggtgtc ccgctgccgg gccaaggcca cggcatctca 1021 gtccagtgcc cagtggggcc gcatcacgac cgagacggcc attcagctta tggggatcat 1081 gtgcgtgctg tcggtctgct ggtctccgct cctgataatg atgttgaaaa tgatcttcaa 1141 tcagacatca gttgagcact gcaagacaca cacggagaag cagaaagaat gcaacttctt 1201 cttaatagct gttcgcctgg cttcactgaa ccagatcttg gatccttggg tttacctgct 1261 gttaagaaag atccttcttc gaaagttttg ccaggaggaa ttttggggaa attaaaacct 1321 gcctttctgc caggatcaca tcactggaag ctccatgact ctctttttgt aaaagaaaa (2) INFORMATION FOR SEQ ID NO:2800: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2800 1 gtgcgcggag gggacgagcg gctggaccac agccggcgcc cgatcaggat ctccgcgctg 61 ggatcggtgg aacttgaggc agcggcggcg cggggcgcca tggcacaccg agcggctccg 121 tcttctgctc ctcagagagc ccggctggcg gcctgggatg acaagatgtc tggactgcaa 181 tcctgcacag ttttgagagg gagatgactt gagtggttgg cttttatctc cacaacaatg 241 tccatgaaca attccaaaca gctagtgtct cctgcagctg cgcttctttc aaacacaacc 301 tgccagacgg aaaaccggct ttccgtattt ttttcagtaa tcttcatgac agtgggaatc 361 ttgtcaaaca gccttgccat cgccattctc atgaaggcat atcagagatt tagacagaag 421 tccaaggcat cgtttctgct tttggccagc ggcctggtaa tcactgattt ctttggccat 481 ctcatcaatg gagccatagc agtatttgta tatgcttctg ataaagaatg gatccgcttt 541 gaccaatcaa atgtcctttg cagtattttt ggtatctgca tggtgttttc tggtctgtgc 601 ccacttcttc taggcagtgt gatggccatt gagcggtgta ttggagtcac aaaaccaata 661 tttcattcta cgaaaattac atccaaacat gtgaaaatga tgttaagtgg tgtgtgcttg 721 tttgctgttt tcatagcttt gctgcccatc cttggacatc gagactataa aattcaggcg 781 tcgaggacct ggtgtttcta caacacagaa gacatcaaag actgggaaga tagattttat 841 cttctacttt tttcttttct ggggctctta gcccttggtg tttcattgtt gtgcaatgca 901 atcacaggaa ttacactttt aagagttaaa tttaaaagtc agcagcacag acaaggcaga 961 tctcatcatt tggaaatggt aatccagctc ctggcgataa tgtgtgtctc ctgtatttgt 1021 tggagcccat ttctggttac aatggccaac attggaataa atggaaatca ttctctggaa 1081 acctgtgaaa caacactttt tgctctccga atggcaacat ggaatcaaat cttagatcct 1141 tgggtatata ttcttctacg aaaggctgtc cttaagaatc tctataagct tgccagtcaa 1201 tgctgtggag tgcatgtcat cagcttacat atttgggagc ttagttccat taaaaattcc 1261 ttaaaggttg ctgctatttc tgagtcacca gttgcagaga aatcagcaag cacctagctt 1321 aataggacag taaatctgtg tggggctaga acaaaaatta agacatgttt ggcaatattt 1381 cagttagtta aatacctgta gcctaactgg aaaattcagg cttcatcatg tagtttgaag 1441 atactattgt cagattcagg ttttgaaatt tgtcaaataa acaggataac tgtacatttt 1501 caacttgttt ttgccaatgg gaggtagaca caataaaata atgccatggg agtcacactg 1561 aaagcaattt tgagcttatc tgtcttattt atgctttgag tgaatcatct gttgaggtct 1621 aatgcctcta cttggcctat ttgccagaga acatcttaat gcagcctgca tagtgaaatg 1681 gttattttga gatcaccgct ctgtagctaa cccttataaa ctaggctcag taaaataaag 1741 cactcttatt ttttgatctg gcctattttg cccctcattg tgtagcctca attaacacat 1801 gcatggtcat gacacccaga attcatgatg gtttgttata acaacctctg catattccag 1861 gtctggcaga caggttgcct gaccctgcaa tcctatctag aatgggccca ttcttgtcac 1921 atttgacaaa taggactgcc tacatttatt attatgaagg tcgattgttg ttggaagtgt 1981 tttttcatgt catagattag caattttcaa ataattattt tttctctgaa aattttgtgt 2041 gtgattgcac aataaataat ttttagagaa acaaaggctc tttctcagca cattgatggg 2101 caactagaat tacagcagtt tcaaactcta ccatggataa tgcaaacaaa ccgaagctac 2161 atgccaatga taggtgcaaa gaatattggc aaaaggtgct ttaccttgag ccattatttg 2221 tgtcagagaa caaaagaaac agaatcaata tataaattca aagactatct gcagctagtg 2281 tgtttcttct ttacacacat atacacacag acatcagaaa attctgttga gagcaggttc 2341 attaaatttg taagatggca tattctaaag cctgtgctac cagtactaag aggggaagac 2401 tggcaatttg ccaagcactt ggggattatt ataacaatta actaggagat caagagataa 2461 taatctctcc ccaaattttc caataataat tgag (2) INFORMATION FOR SEQ ID NO:2801: (i) SEQUENCE CHARACTERISTICS: WO 00/09525 PCT/US99/17712 EPI-109 1064 (A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2801 1 ggcacagacg cacgggacag gagagcctgg gcaagactgg agagcccaga cctgggatgg 61 cggattcgtg caggaacctc acctacgtgc ggggctcggt ggggccggcc accagcaccc 121 tgatgttcgt ggccggtgtg gtgggcaacg ggctggccct gggcatcctg agcgcacggc 181 gaccggcgcg cccctcggcc ttcgcggtgc tggtcaccgg actggcggcc accgacctgc 241 tgggcaccag cttcctgagc ccggccgtgt tcgtggccta tgcgcgcaac agctccctgc 301 tgggcctggc ccgaggcggc cccgccctgt gcgatgcctt cgccttcgcc atgaccttct 361 tcggcctggc gtccatgctc atcctctttg ccatggccgc ggagcgctgc ctggcgctga 421 gccaccccta cctctacgcg cagctggacg ggccccgctg cgcccgcctg gcgctgccag 481 ccatctacgc cttctgcgtc ctcttctgcg cgctgcccct gctgggcctg ggccaacacc 541 agcagtactg ccccggcagc tggtgcttcc tccgcatgcg ctgggcccag ccgggcggcg 601 ccgccttctc gctggcctac gccggcctgg tggccctgct ggtggctgcc atcttcctct 661 gcaacggctc ggtcaccctc agcctctgcc gcatgtaccg ccagcagaag cgccaccagg 721 gctctctggg tccacggccg cgcaccggag aggacgaggt ggaccacctg atcctgctgg 781 ccctcatgac agtggtcatg gccgtgtgct ccctgcctct cacgatccgc tgcttcaccc 841 aggctgtcgc ccctgacagc agcagtgaga tgggggacct ccttgccttc cgcttctacg 901 ccttcaaccc catcctggac ccctgggtct tcatcctttt ccgcaaggct gtcttccagc 961 gactcaagct ctgggtctgc tgcctgtgcc tcgggcctgc ccacggagac tcgcagacac 1021 ccctttccca gctcgcctcc gggaggaggg acccaagggc cccctctgct cctgtgggaa 1081 aggaggggag ctgcgtgcct ttgtcggctt ggggcgaggg gcaggtggag cccttgcctc 1141 ccacacagca gtccagcggc agcgccgtgg gaacgtcgtc caaagcagaa gccagcgtcg 1201 cctgctccct ctgctgacat ttcaagctga ccctgtgatc tctgccctgt cttcgggcga 1261 caggagccag aaaatcaggg acatggctga tggctgcgga tgctggaacc ttggccccca 1321 aactctgggg ccgatcagct gctgtttctc tgcggcaggg cagtcgctgc tggctctggg 1381 aagagagtga gggacagagg aaacgtttat cctggag (2) INFORMATION FOR SEQ ID NO:2802: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: _base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2802 1 gctgtgcaac ctcggcgcca tgcgcaacct ctatgcgatg caccggcggc tgcagcggca 61 cccgcgctcc tgcaccaggg actgtgccga gccgcgcgcg gacgggaggg aagcgtcccc 121 tcagcccctg gaggagctgg atcacctcct gctgctggcg ctgatgaccg tgctcttcac 181 tatgtgttct ctgcccgtaa tttatcgcgc ttactatgga gcatttaagg atgtcaagga 241 gaaaaacagg acctctgaag aagcagaaga cctccgagcc ttgcgatttc tatctgtgat 301 ttcaattgtg gacccttgga tttttatcat tttcagatct ccagtatttc ggatattttt 361 tcacaagatt ttcattagac ctcttaggta caggagccgg tgcagcaatt ccactaacat 421 ggaatccagt cagtgacagt gtttttcact ctgtggtaag ctgaggaata tgtcacattt 481 tcagtcaaag aacca 1 gaattctggc tattttcctc ctgccgttcc gactcggcac cagagtctgt ctctactgag 61 aacgcagcgc gtcagggccg agctcttcac tggcctgctc cgcgctcttc aatgccagcg 121 ccaggcgctc accctgcaga gcgtcccgcc tctcaaagag gggtgtgacc cgcgagttta 181 gataggaggt tcctgccgtg gggaacaccc cgccgccctc ggagcttttt ctgtggcgca 241 gcttctccgc ccgagccgcg cgcggagctg ccgggggctc cttagcaccc gggcgccggg 301 gccctcgccc ttccgcagcc ttcactccag ccctctgctc ccgcacgcca tgaagtcgcc 361 gttctaccgc tgccagaaca ccacctctgt ggaaaaaggc aactcggcgg tgatgggcgg 421 ggtgctcttc agcaccggcc tcctgggcaa cctgctggcc ctggggctgc tggcgcgctc 481 ggggctgggg tggtgctcgc ggcgtccact gcgcccgctg ccctcggtct tctacatgct 541 ggtgtgtggc ctgacggtca ccgacttgct gggcaagtgc ctcctaagcc cggtggtgct 601 ggctgcctac gctcagaacc ggagtctgcg ggtgcttgcg cccgcattgg acaactcgtt 661 gtgccaagcc ttcgccttct tcatgtcctt ctttgggctc tcctcgacac tgcaactcct 721 ggccatggca ctggagtgct ggctctccct agggcaccct ttcttctacc gacggcacat 781 caccctgcgc ctgggcgcac tggtggcccc ggtggtgagc gccttctccc tggctttctg 841 cgcgctacct ttcatgggct tcgggaagtt cgtgcagtac tgccccggca cctggtgctt 901 tatccagatg gtccacgagg agggctcgct gtcggtgctg gggtactctg tgctctactc 961 cagcctcatg gcgctgctgg tcctcgccac cgtgctgtgc aacctcggcg ccatgcgcaa 1021 cctctatgcg atgcaccggc ggctgcagcg gcacccgcgc tcctgcacca gggactgtgc 1081 cgagccgcgc gcggacggga gggaagcgtc ccctcagccc ctggaggagc tggatcacct 1141 cctgctgctg gcgctgatga ccgtgctctt cactatgtgt tctctgcccg taattgtgag 1201 tccccgggcc ccgagg 1 gggccgccgt cggcgcgccg ggtgcgggaa gggggctctg gatttcggtc cctccccttt 61 ttcctctgag tctcggaacg ctccagctct cagaccctct tcctcccagg taaaggccgg WO 00/09525 PCT/US99/17712 EPI-109 1065 121 gaqaggaggg cgcatctctt ttccaggcac cccaccatgg gcaatgcctc caatgactcc 181 cagtctgagg actgcgagac gcgacagtgg cttcccccag gcgaaagccc agccatcagc 241 tccgtcatgt tctcggccgg ggtgctgggg aacctcatag cactggcgct gctggcgcgc 301 cgctggcggg gggacgtggg gtgcagcgcc ggccgcagga gctccctctc cttgttccac 361 gtgctggtga ccgagctggt gttcaccgac ctgctcggga cctgcctcat cagcccagtg 421 gtactggctt cgtacgcgcg gaaccagacc ctggtggcac tggcgcccga gagccgcgcg 481 tgcacctact tcgctttcgc catgaccttc ttcagcctgg ccacgatgct catgctcttc 541 gccatggccc tggagcgcta cctctcgatc gggcacccct acttctacca gcgccgcgtc 601 tcggcctccg ggggcctggc cgtgctgcct gtcatctatg cagtctccct gctcttctgc 661 tcgctgccgc tgctggacta tgggcagtac gtccagtact gccccgggac ctggtgcttc 721 atccggcacg ggcggaccgc ttacctgcag ctgtacgcca ccctgctgct gcttctcatt 781 gtctcggtgc tcgcctgcaa cttcagtgtc attctcaacc tcatccgcat gcaccgccga 841 agccggagaa gccgctgcgg accttccctg ggcagtggcc ggggcggccc cggggcccgc 901 aggagagggg aaagggtgtc catggcggag gagacggacc acctcattct cctggctatc 961 atgaccatca ccttcgccgt ctgctccttg cctttcacga tttttgcata tatgaatgaa 1021 acctcttccc gaaaggaaaa atgggacctc caagctctta ggtttttatc aattaattca 1081 ataattgacc cttgggtctt tgccatcctt aggcctcctg ttctgagact aatgcgttca 1141 gtcctctgtt gtcggatttc attaagaaca caagatgcaa cacaaacttc ctgttctaca 1201 cagtcagatg ccagtaaaca ggctgacctt tgaggtcagt agtttaaaag ttcttagtta 1261 tatagcatct ggaagatcat tttgaaattg ttccctggag aaatgaaaac agtgtgtaaa 1321 caaaatgaag ctgccctaat aaaaaggagt atacaaacat ttaagctgtg gtcaaggcta 1381 cagatgtgct gacaaggcac ttcatgtaaa gtgtcagaag gagctacaaa acctaccctc 1441 aatgagcatg gtacttggcc tttggaggaa caatcggctg cattgaagat ccagctgcct 1501 attgatttaa gctttcctgt tgaatgacaa agtatgtggt tttgtaattt gtttgaaacc 1561 ccaaacagtg actgtacttt ctattttaat cttgctacta ccgttataca catatagtgt 1621 acagccagac cagattaaac ttcatatgta atctctagga agtcaatatg tggaagcaac 1681 caagcctgct gtcttgtgat cacttagcga accctttatt tgaacaatga agttgaaaat 1741 cataggcacc ttttactgtg atgtttgtgt atgtgggagt actctcatca ctacagtatt 1801 actcttacaa gagtggactc agtgggttaa catcagtttt gtttactcat cctccaggaa 1861 ctgcaggtca agttgtcagg ttatttattt tataatgtcc atatgctaat agtgatcaag 1921 aagactttag gaatggttct ctcaacaaga aataatagaa atgtctcaag gcagttaatt 1981 ctcattaata ctcttatta *t cctat ttctg ggggaggatg tacgtggcca tgtatgaagc 2041 caaatattag gcttaaaaac tgaaaaatct ggttcattct tcagatatac tggaaccctt 2101 ttaaagttga tattggggcc atgagtaaaa tagattttat aagatgactg tgttgtacca 2161 aaattcatct gtctatattt tatttagggg aacatggttt gactcatctt atatgggaaa 2221 ccatgtagca gtgagtcata tcttaatata tttctaaatg tttggcatgt aaatgtaaac 2281 tcagcatcaa aatatttcag tgaatttgca ctgtttaatc atagttactg tgtaaactca 2341 tctgaaatgt tacaaaaata aactataaaa ca 1 agagaggaag gcgtggctcc ctcccgggcc agtgagccct ggcgccgccg cggccgcggt 61 cccagcagcg gagtagggcg gcggctgcgc cccgcaccat ggggggcagc ccagccccag 121 ccgcggtaaa cgccgacctc cgccgccgcc cgcgccgcgt ctgccccctc ccgctgcggc 181 tctctggacg ccatcccctc ctcacctcga agccaacatg aaggagaccc ggggctacgg 241 aggggatgcc cccttctgca cccgcctcaa ccactcctac acaggcatgt gggcgcccga 301 gcgttccgcc gaggcgcggg gcaacctcac gcgccctcca gggtctagcg aggattgcgg 361 atcggtgtcc gtggccttcc cgatcaccat gctgctcact ggtttcgtgg gcaacgcact 421 ggccatgctg ctcgtgtcgc gcagctaccg gcgccgggag agcaagcgca agaagtcctt 481 cctgctgtgc atcggctggc tggcgctcac cgacctggtc gggcagcttc tcaccacccc 541 ggtcgtcatc gtcgtgtacc tgtccaagca gcgttgggag cacatcgacc cgtcggggcg 601 gctctgcacc tttttcgggc tgaccatgac tgttttcggg ctctcctcgt tgttcatcgc 661 cagcgccatg gccgtcgagc gggcgctggc catcagggcg ccgcactggt atgcgagcca 721 catgaagacg cgtgccaccc gcgctgtgct gctcggcgtg tggctggccg tgctcgcctt 781 cgccctgctg ccggtgctgg gcgtgggcca gtacaccgtc cagtggcccg ggacgtggtg 841 cttcatcagc accgggcgag ggggcaacgg gactagctct tcgcataact ggggcaacct 901 tttcttcgcc tctgcctttg ccttcctggg gctcttggcg ctgacagtca ccttttcctg 961 caacctggcc accattaagg ccctggtgtc ccgctgccgg gccaaggcca cggcatctca 1021 gtccagtgcc cagtggggcc gcatcacgac cgagacggcc attcagctta tggggatcat 1081 gtgcgtgctg tcggtctgct ggtctccgct cctgataatg atgttgaaaa tgatcttcaa 1141 tcagacatca gttgagcact gcaagacaca cacggagaag cagaaaaaat gcaacttctt 1201 cttaatagct gttcgczctgg cttcactgaa ccagatcttg gatccttggg tttacctgct 1261 *gttaagaaag atccttcttc gaaagttttg ccaggtagca aatgctgtct ccagctgctc 1321 taatgatgga cagaaagggc agcctatctc attatctaat gaaataatac agacagaagc 1381 atgaaagaaa acacttaact tgcatgtgca cagcttctgg taacaaatat cgctaaacct 1441 tactgtgaat ttaggcatct ctggcatgcc actgtttatg cattgaagtg gaatttttgg 1501 tataaagcta aatggtctta gaagcataga aaatccctat gtgccaaaag tagtgaaaca 1561 caaacaaagg aaaatatatt aataacagtc tagtgttttt gttgagtctg ccattcgtag 1621 ctgaatatgt gattaattat gtgatgaaaa ctttttttat aaatgatctt ggtctattgg 1681 gg 1 cccgggccag tgagccctgg cgccgccgcg gccgcggtcc cagcaacgga gtagggcggc WO 00/09525 PCT/US99/17712 EPI-109 1066 61 qgctgcgccc cgcaccatgg ggggcagccc agccccagcc gcggtaaacg ccgacctccg 121 ccgccgcccg cgccgcgtct gccccctccc gctgcggctc tctggacgcc atcccctcct 181 cacctcgaag ccaacatgaa ggagacccgg ggctacggag gggatgcccc cttctgcacc 241 cgcctcaacc actcctacac aggcatgtgg gcgcccgagc gttccgccga ggcgcggggc 301 aacctcacgc gccctccagg gtctggcgag gattgcggat cggtgtccgt ggccttcccg 361 atcaccatgc tgctcactgg tttcgtgggc aacgcactgg ccatgctgct cgtgtcgcgc 421 agctaccggc gccgggagag caagcgcaag aagtccttcc tgctgtgcat cggctggctg 481 gcgctcaccg acctggtcgg gcagcttctc accaccccgg tcgtcatcgt cgtgtacctg 541 tccaagcagc gttgggagca catcgacccg tcggggcggc tctgcacctt tttcgggctg 601 accatgactg ttttcgggct ctcctcgttg ttcatcgcca gcgccatggc cgtcgagcgg 661 gcgctggcca tcagggcgcc gcactggtat gcgagccaca tgaagacgcg tgccacccgc 721 gctgtgctgc tcggcgtgtg gctggccgtg ctcgccttcg ccctgctgcc ggtgctgggc 781 gtgggccagt acaccgtcca gtggcccggg acgtggtgct tcatcagcac cgggcgaggg 841 ggcaacggga ctagctcttc gcataactgg ggcaaccttt tcttcgcctc tgcctttgcc 901 ttcctggggc tcttggcgct gacagtcacc ttttcctgca acctggccac cattaaggcc 961 ctggtgtccc gctgccgggc caaggccacg gcatctcagt ccagtgccca gtggggccgc 1021 atcacgaccg agacggccat tcagcttatg gggatcatgt gcgtgctgtc ggtctgctgg 1081 tctccgctcc tgataatgat gttgaaaatg atcttcaatc agacatcagt tgagcactgc 1141 aagacacaca cggagaagca gaaagaatgc aacttcttct taatagctgt tcgcctggct 1201 tcactgaacc agatcttgga tccttgggtt tacctgctgt taagaaagat ccttcttcga 1261 aagttttgcc agatcaggta ccacacaaac aactatgcat ccagctccac ctccttaccc 1321 tgccagtgtt cctcaacctt gatgtggagc gaccatttgg aaagataatg aaagaacgga 1381 gttggacatt ttattgcaat tcctgcttcc ctgaatttgc atatttcttc ccacctgaga 1441 aggataatta tatattttaa tttggattat ttcttcattt ttatcttttt attttaatga 1501 ttgttttgtc agtaataccc atggagatca actttattat tataatccat gcctctgaat 1561 attagattgg tttcttggat gggattttga atatgcattt aagaagttgg gaagaatttc 1621 acagatgatg attggaggaa aagtgatgaa aagaaagacc tgtgttccag gagttttctc 1681 caacttcaaa cctttacgtg aatcttaacc aaagtggaca tctttacatt tcatgatagc 1741 ttgcttttgc aatatgagtt tgaaaaatca gtataagctt atgatggtga aaagtcaaca 1801 tattgagagt gataattcaa ttaataggat atgaacttaa cgatataaaa gcaaatgagg 1861 gcaggagggg 1 agagaggaag gcgtggctcc ctcccgggcc agtgagccct ggcgccgccg cggccgcggt 61 cccagcagcg gagtagggcg gcggctgcgc cccgcaccat ggggggcagc ccagccccag 121 ccgcggtaaa cgccgacctc cgccgccgcc cgcgccgcgt ctgccccctc ccgctgcggc 181 tctctggacg ccatcccctc ctcacctcga agccaacatg aaggagaccc ggggctacgg 241 aggggatgcc cccttctgca cccgcctcaa ccactcctac acaggcatgt gggcgcccga 301 gcgttccgcc gaggcgcggg gcaacctcac gcgccctcca gggtctggcg aggattgcgg 361 atcggtgtcc gtggccttcc cgatcaccat gctgctcact ggtttcgtgg gcaacgcact 421 ggccatgctg ctcgtgtcgc gcagctaccg gcgccgggag agcaagcgca agaagtcctt 481 cctgctgtgc atcggctggc tggcgctcac cgacctggtc gggcagcttc tcaccacccc 541 ggtcgtcatc gtcgtgtacc tgtccaagca gcgttgggag cacatcgacc cgtcggggcg 601 gctctgcacc tttttcgggc tgaccatgac tgttttcggg ctctcctcgt tgttcatcgc 661 cagcgccatg gccgtcgagc gggcgctggc catcagggcg ccgcactggt atgcgagcca 721 catgaagacg cgtgccaccc gcgctgtgct gctcggcgtg tggctggccg tgctcgcctt 781 cgccctgctg ccggtgctgg gcgtgggcca gtacaccgtc cagtggcccg ggacgtggtg 841 cttcatcagc accgggcgag ggggcaacgg gactagctct tcgcataact ggggcaacct 901 tttcttcgcc tctgcctttg ccttcctggg gctcttggcg ctgacagtca ccttttcctg 961 caacctggcc accattaagg ccctggtgtc ccgctgccgg gccaaggcca cggcatctca 1021 gtccagtgcc cagtggggcc gcatcacqac cgagacggcc attcagctta tggggatcat 1081 gtgcgtgctg tcggtctgct ggtctccgct cctgataatg atgttgaaaa tgatcttcaa 1141 tcagacatca gttgagcact gcaagacaca cacggagaag cagaaagaat gcaacttctt 1201 cttaatagct gttcgcctgg cttcactgaa ccagatcttg gatccttggg tttacctgct 1261 gttaagaaag atccttcttc gaaagttttg ccaggtagca aatgctgtct ccagctgctc 1321 taatgatgga cagaaagggc agcctatctc attatctaat gaaataatac agacagaagc 1381 atgaaagaaa acacttaact tgcatgtgca cagcttctgg taacaaatat cgctaaacct 1441 tactgtgaat ttaggcatct ctggcatgcc actgtttatg cattgaagtg gaatttttgg 1501 tataaagcta aatggtctta gaagcataga aaatccctat gtgccaaaag tagtgaaaca 1561 caaacaaagg aaaatatatt aataacagtc tagtgttttt gttgagtctg ccattcgtag 1621 ctgaatatgt gattaattat gtgatgaaaa ctttttttat aaatgatctt ggtctattgg 1681 gg 1 agagaggaag gcgtggctcc ctcccgggcc agtgagccct ggcgccgccg cggccgcggt 61 cccagcagcg gagtagggcg gcggctgcgc cccgcaccat ggggggcagc ccagccccag 121 ccgcggtaaa cgccgacctc cgccgccgcc cgcgccgcgt ctgccccctc ccgctgcggc 181 tctctggacg ccatcccctc ctcacctcga agccaacatg aaggagaccc ggggctacgg 241 aggggatgcc cccttctgca cccgcctcaa ccactcctac acaggcatgt gggcgcccga 301 gcgttccgcc gaggcgcggg gcaacctcac gcgccctcca gggtctggcg aggattgcgg 361 atcggtgtcc gtggccttcc cgatcaccat gctgctcact ggtttcgtgg gcaacgcact 421 ggccatgctg ctcgtgtcgc gcagctaccg gcgccgggag agcaagcgca agaagtcctt WO 00/09525 PCTIUS99/17712 EPI-109 1067 481 cctgctgtgc atcggctggc tggcgctcac cgacctggtc gggcagcttc tcaccacccc 541 ggtcgtcatc gtcgtgtacc tgtccaagca gcgttgggag cacatcgacc cgtcggggcg 601 gctctgcacc tttttcgggc tgaccatgac tgttttcggg ctctcctcgt tgttcatcgc 661 cagcgccatg gccgtcgagc gggcgctggc catcagggcg ccgcactggt atgcgagcca 721 catgaagacg cgcgccaccc gcgctgtgct gctcggcgtg tggctggccg tgctcgcctt 781 cgccctgctg ccggtgctgg gcgtgggcca gtacaccgtc cagtggcccg ggacgtggtg 841 cttcatcagc accgggcgag ggggcaacgg gactagctct tcgcataact ggggcaacct 901 tttcttcgcc tctgcctttg ccttcctggg gctcttggcg ctgacagtca ccttttcctg 961 caacctggcc accattaagg ccctggtgtc ccgctgccgg gccaaggcca cggcatctca 1021 gtccagtgcc cagtggggcc gcatcacgac cgagacggcc attcagctta tggggatcat 1081 gtgcgtgctg tcggtctgct ggtctccgct cctgataatg atgttgaaaa tgatcttcaa 1141 tcagacatca gttgagcact gcaagacaca cacggagaag cagaaagaat gcaacttctt 1201 cttaatagct gttcgcctgg cttcactgaa ccagatcttg gatccttggg tttacctgct 1261 gttaagaaag atccttcttc gaaagttttg ccaggaggaa ttttggggaa attaaaacct 1321 gcctttctgc caggatcaca tcactggaag ctccatgact ctctttttgt aaaagaaaa 1 gtgcgcggag gggacgagcg gctggaccac agccggcgcc cgatcaggat ctccgcgctg 61 ggatcggtgg aacttgaggc agcggcggcg cggggcgcca tggcacaccg agcggctccg 121 tcttctgctc ctcagagagc ccggctggcg gcctgggatg acaagatgtc tggactgcaa 181 tcctgcacag ttttgagagg gagatgactt gagtggttgg cttttatctc cacaacaatg 241 tccatgaaca attccaaaca gctagtgtct cctgcagctg cgcttctttc aaacacaacc 301 tgccagacgg aaaaccggct ttccgtattt ttttcagtaa tcttcatgac agtgggaatc 361 ttgtcaaaca gccttgccat cgccattctc atgaaggcat atcagagatt tagacagaag 421 tccaaggcat cgtttctgct tttggccagc ggcctggtaa tcactgattt ctttggccat 481 ctcatcaatg gagccatagc agtatttgta tatgcttctg ataaagaatg gatccgcttt 541 gaccaatcaa atgtcctttg cagtattttt ggtatctgca tggtgttttc tggtctgtgc 601 ccacttcttc taggcagtgt gatggccatt gagcggtgta ttggagtcac aaaaccaata 661 tttcattcta cgaaaattac atccaaacat gtgaaaatga tgttaagtgg tgtgtgcttg 721 tttgctgttt tcatagcttt gctgcccatc cttggacatc gagactataa aattcaggcg 781 tcgaggacct ggtgtttcta caacacagaa gacatcaaag actqggaaga tagattttat 841 cttctacttt tttcttttct ggggctctta gcccttggtg tttcattgtt gtgcaatgca 901 atcacaggaa ttacactttt aagagttaaa tttaaaagtc agcagcacag acaaggcaga 961 tctcatcatt tggaaatggt aatccagctc ctggcgataa tgtgtgtctc ctgtatttgt 1021 tggagcccat ttctggttac aatggccaac attggaataa atggaaatca ttctctggaa 1081 acctgtgaaa caacactttt tgctctccga atggcaacat ggaatcaaat cttagatcct 1141 tgggtatata ttcttctacg aaaggctgtc cttaagaatc tctataagct tgccagtcaa 1201 tgctgtggag tgcatgtcat cagcttacat atttgggagc ttagttccat taaaaattcc 1261 ttaaaggttg ctgctatttc tgagtcacca gttgcagaga aatcagcaag cacctagctt 1321 aataggacag taaatctgtg tggggctaga acaaaaatta agacatgttt ggcaatattt 1381 cagttagtta aatacctgta gcctaactgg aaaattcagg cttcatcatg tagtttgaag 1441 atactattgt cagattcagg ttttgaaatt tgtcaaataa acaggataac tgtacatttt 1501 caacttgttt ttgccaatgg gaggtagaca caataaaata atgccatggg agtcacactg 1561 aaagcaattt tgagcttatc tgtcttattt atgctttgag tgaatcatct gttgaggtct 1621 aatgcctcta cttggcctat ttgccagaga acatcttaat gcagcctgca tagtgaaatg 1681 gttattttga gatcaccgct ctgtagctaa cccttataaa ctaggctcag taaaataaag 1741 cactcttatt ttttgatctg gcctattttg cccctcattg tgtagcctca attaacacat 1801 gcatggtcat gacacccaga attcatgatg gtttgttata acaacctctg catattccag 1861 gtctggcaga caggttgcct gaccctgcaa tcctatctag aatgggccca ttcttgtcac 1921 atttgacaaa taggactgcc tacatttatt attatgaagg tcgattgttg ttggaagtgt 1981 tttttcatgt catagattag caattttcaa ataattattt tttctctgaa aattttgtgt 2041 gtgattgcac aataaataat ttttagagaa acaaaggctc tttctcagca cattgatggg 2101 caactagaat tacagcagtt tcaaactcta ccatggataa tgcaaacaaa ccgaagctac 2161 atgccaatga taggtgcaaa gaatattggc aaaaggtgct ttaccttgag ccattatttg 2221 tgtcagagaa caaaagaaac agaatcaata tataaattca aagactatct gcagctagtg 2281 tgtttcttct ttacacacat atacacacag acatcagaaa attctgttga gagcaggttc 2341 attaaatttg taagatggca tattctaaag cctgtgctac cagtactaag aggggaagac 2401 tggcaatttg ccaagcactt ggggattatt ataacaatta actaggagat caagagataa 2461 taatctctcc ccaaattttc caataataat tgag 1 ggcacagacg cacgggacag gagagcctgg gcaagactgg agagcccaga cctgggatgg 61 cggattcgtg caggaacctc acctacgtgc ggggctcggt ggggccggcc accagcaccc 121 tgatgttcgt ggccggtgtg gtgggcaacg ggctggccct gggcatcctg agcgcacggc 181 gaccggcgcg cccctcggcc ttcgcggtgc tggtcaccgg actggcggcc accgacctgc 241 tgggcaccag cttcctgagc ccggccgtgt tcgtggccta tgcgcgcaac agctccctgc 301 tgggcctggc ccgaggcggc cccgccctgt gcgatgcctt cgccttcgcc atgaccttct 361 tcggcctggc gtccatgctc atcctctttg ccatggccgt ggagcgctgc ctggcgctga 421 gccaccccta cctctacgcg cagctggacg ggccccgctg cgcccgcctg gcgctgccag 481 ccatctacgc cttctgcgtc ctcttctgcg cgctgcccct gctgggcctg ggccaacacc 541 agcagtactg ccccggcagc tggtgcttcc tccgcatgcg ctgggcccag ccgggcggcg 601 ccgccttctc gctggcctac gccggcctgg tggccctgct ggtggctgcc atcttcctct WO 00/09525 PCT/US99/17712 EPI-109 1068 661 gcaacggctc ggtcaccctc agcctctgcc gcatgtaccg ccagcagaag cgccaccagg 721 gctctctggg tccacggccg cgcaccggag aggacgaggt ggaccacctg atcctgctgg 781 ccctcatgac agtggtcatg gccgtgtgct ccctgcctct cacgatccgc tgcttcaccc 841 aggctgtcgc ccctgacagc agcagtgaga tgggggacct ccttgccttc cgcttctacg 901 ccttcaaccc catcctggac ccctgggtct tcatcctttt ccgcaaggct gtcttccagc 961 gactcaagct ctgggtctgc tgcctgtgcc tcgggcctgc ccacggagac tcgcagacac 1021 ccctttccca gctcgcctcc gggaggaggg acccaagggc cccctctgct cctgtgggaa 1081 aggaggggag ctgcgtgcct ttgtcggctt ggggcgaggg gcaggtggag cccttgcctc 1141 ccacacagca atccagcggc agcgccgtgg gaacgtcgtc caaagcagaa gccagcgtcg 1201 cctgctccct ctgctgacat ttcaagctga ccctgtgatc tctgccctgt cttcgggcga 1261 caggagccag aaaatcaggg acatggctga tggctgcgga tgctggaacc ttggccccca 1321 aactctgggg ccgatcagct gctgtttctc tgcggcaggg cagtcgctgc tggctctggg 1381 aagagagtga gggacagagg aaacgtttat cctggag (2) INFORMATION FOR SEQ ID NO:2803: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2803 1 gctttctcct agggactgtg aggggcgctt ctgactttgg acttgagcac tgcctgggac 61 ctgtgctgag agagcgctag catgtctcag tggaatcaag tccaacagtt agaaatcaag 121 tttttggagc aggtggatca attctatgat gacaactttc ccatggaaat tcggcatctg 181 ttggcccaat ggattgaaaa tcaagactgg gaggcagctt ctaacaatga aaccatggca 241 acgattcttc ttcaaaactt gttaatacaa ctggatgaac agttaggtcg tgtttccaaa 301 gagaaaaacc tactcttgat acacaatcta aaaagaatta ggaaggtcct tcagggaaaa 361 tttcatggaa atccaatgca tgtagctgtg gttatttcaa actgtttaag ggaagagagg 421 agaatattgg ctgcagccaa catgcctgtc caggggcctc tagagaaatc cttacaaagt 481 tcttcagttt cagaaagaca gaggaatgtg gagcacaaag tggctgccat taaaaacagt 541 gtgcagatga cagaacaaga taccaaatac ttagaagatc tgcaagacga atttgactac 601 aggtataaaa caattcagac aatggatcag agtgacaaga atagtgccat ggtgaatcag 661 gaagttttga cactgcagga aatgcttaac agcctcgatt tcaagagaaa ggaggctctc 721 agtaaaatga cccaaatcat ccatgagaca gacctgttaa tgaacaccat gctcatagaa 781 gagctgcaag actggaagcg gcggcagcaa atcgcctgca tcgggggtcc actccacaat 841 gggctcgacc agcttcagaa ctgctttaca ctattggcag aaagtctttt ccaactgaga 901 aggcaattgg agaaactaga ggagcaatct accaaaatga catatgaagg tgatcccatt 961 ccaatgcaaa gaactcacat gctagaaaga gtcaccttct tgatctacaa ccttttcaag 1021 aactcatttg tggttgagcg acagccatgt atgccaaccc accctcagag gccgttggta 1081 cttaaaaccc taattcagtt cactgtaaaa ctaaggctac taataaaatt gccagaacta 1141 aactatcagg taaaggttaa ggcatcaatt gacaagaatg tttcaactct aagcaaccga 1201 agatttgtac tttgtggaac taatgtcaaa gccatgtcta ttgaagaatc ttccaatggg 1261 agtctctcag tagaatttcg acatttgcaa ccaaaggaaa tgaagtccag tgctggaggt 1321 aaaggaaatg agggctgtca catggtgact gaagaacttc attccataac gtttgaaaca 1381 cagatctgcc tctatggcct gaccatagat ttggagacca gctcattgcc tgtggtgatg 1441 atttccaatg tcagtcagtt acctaatgct tgggcatcca tcatttggta caacgtgtca 1501 accaacgatt cccagaactt ggttttcttt aataatcctc cacctgccac attgagtcaa 1561 ctactggagg tgatgagctg gcagttttca tcgtacgttg gtcgtggtct taactcagat 1621 caactccata tgctggcaga gaagcttaca gtccaatcta gctacagtga tggtcacctc 1681 acctgggcca agttctgcaa ggaacattta cctggtaaat catttacctt ttggacatgg 1741 cttgaagcaa tattggatct aattaagaaa cacattcttc ccctttggat tgatgggtat 1801 gtcatgggct ttgttagcaa agagaaggaa cggctgttgc taaaggataa aatgcctggc 1861 acctttttat taagattcag tgaaagccat ctcggaggaa taactttcac ctgggtggac 1921 cattctgaaa gtggggaagt gagattccac tctgtagaac cctacaataa aggccggttg 1981 tctgctctgc cattcgctga catcctgcga gactacaaag ttattatggc tgaaaacatt 2041 cctgaaaacc ctctgaagta cctatatcct gacattccca aagacaaagc cttcggtaaa 2101 cactacagct ctcagccttg cgaagtttca agaccaacag aaaggggtga caaaggttat 2161 gttccttctg tttttatccc catctcaaca atccgaagtg attcaacaga gccacattct 2221 ccatcagacc ttcttcccat gtctccaagt gtgtatgcgg tgttgagaga aaacctgagt 2281 cccacaacaa ttgaaactgc aatgaagtct ccttattctg ctgaatgaca ggataaactc 2341 tgacgcacca agaaaggaag caaatgaaaa agtttaaaga ctgttctttg cccaataacc 2401 acattttatt tcttcagctt tgtaaatacc aggttctagg aaatgtttga catctgaagc 2461 tctcttcaca ctcccgtggc actcctcaat tgggagtgtt gtgactgaaa tgcttgaaac 2521 caaagcttca gataaacttg caagataaga caactttaag aaaccagtgt taataacaat 2581 attaacag (2) INFORMATION FOR SEQ ID NO:2804: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: base pairs WO 00/09525 PCT/US99/17712 EPI-109 1069 (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2804 1 gctttctcct agggactgtg aggggcgctt ctgactttgg acttgagcac tgcctgggac 61 ctgtgctgag agagcgctag catgtctcag tggaatcaag tccaacagtt agaaatcaag 121 tttttggagc aggtggatca attctatgat gacaactttc ccatggaaat tcggcatctg 181 ttggcccaat ggattgaaaa tcaagactgg gaggcagctt ctaacaatga aaccatggca 241 acgattcttc ttcaaaactt gttaatacaa ctggatgaac agttaggtcg tgtttccaaa 301 gagaaaaacc tactcttgat acacaatcta aaaagaatta ggaaggtcct tcagggaaaa 361 tttcatggaa atccaatgca tgtagctgtg gttatttcaa actgtttaag ggaagagagg 421 agaatattgg ctgcagccaa catgcctgcc caggggcctc tagagaaatc cttacaaagt 481 tcttcagttt cagaaagaca gaggaatgtg gagcacaaag tggctgccat taaaaacagt 541 gtgcagatga cagaacaaga taccaaatac ttagaagatc tgcaagacga atttgactac 601 aggtataaaa caattcagac aatggatcag agtgacaaga atagtgccat ggtgaatcag 661 gaagttttga cactgcagga aatgcttaac agcctcgatt tcaagagaaa ggaggctctc 721 agtaaaatga cccaaatcat ccatgagaca gacctgttaa tgaacaccat gctcatagaa 781 gagctgcaag actggaagcg gcggcagcaa atcgcctgca tcgggggtcc actccacaat 841 gggctcgacc agcttcagaa ctgctttaca ctattggcag aaagtctttt ccaactgaga 901 aggcaattgg agaaactaga ggagcaatct accaaaatga catatgaagg tgatcccatt 961 ccaatgcaaa gaactcacat gctagaaaga gtcaccttct tgatctacaa ccttttcaag 1021 aactcatttg tggttgagcg acagccatgt atgccaaccc accctcagag gccgttggta 1081 cttaaaaccc taattcagtt cactgtaaaa ctaaggctac taataaaatt gccagaacta 1141 aactatcagg taaaggttaa ggcatcaatt gacaagaatg tttcaactct aagcaaccga 1201 agatttgtac tttgtggaac taatgtcaaa gccatgtcta ttgaagaatc ttccaatggg 1261 agtctctcag tagaatttcg acatttgcaa ccaaaggaaa tgaagtccag tgctggaggt 1321 aaaggaaatg agggctgtca catggtgact gaagaacttc attccataac gtttgaaaca 1381 cagatctgcc tctatggcct gaccatagat ttggagacca gctcattgcc tgtggtgatg 1441 atttccaatg tcagtcagtt acctaatgct tgggcatcca tcatttggta caacgtgtca 1501 accaacgatt cccagaactt ggttttcttt aataatcctc cacctgccac attgagtcaa 1561 ctactggagg tgatgagctg gcagttttca tcgtacgttg gtcgtggtct taactcagat 1621 caactccata tgctggcaga gaagcttaca gtccaatcta gctacagtga tggtcacctc 1681 acctgggcca agttctgcaa ggaacattta cctggtaaat catttacctt ttggacatgg 1741 cttgaagcaa tattggatct aattaagaaa cacattcttc ccctttggat tgatgggtat 1801 gtcatgggct ttgttagcaa agagaaggaa cggctgttgc taaaggataa aatgcctggc 1861 acctttttat taagattcag tgaaagccat ctcggaggaa taactttcac ctgggtggac 1921 cattctgaaa gtggggaagt gagattccac tctgtagaac cctacaataa aggccggttg 1981 tctgctctgc cattcgctga catcctgcga gactacaaag ttattatggc tgaaaacatt 2041 cctgaaaacc ctctgaagta cctatatcct gacattccca aagacaaagc cttcggtaaa 2101 cactacagct ctcagccttg cgaagtttca agaccaacag aaaggggtga caaaggttat 2161 gttccttctg tttttatccc catctcaaca atccgaagtg attcaacaga gccacattct 2221 ccatcagacc ttcttcccat gtctccaagt gtgtatgcgg tgttgagaga aaacctgagt 2281 cccacaacaa ttgaaactgc aatgaagtct ccttattctg ctgaatgaca ggataaactc 2341 tgacgcacca agaaaggaag caaatgaaaa agtttaaaga ctgttctttg cccaataacc 2401 acattttatt tcttcagctt tgtaaatacc aggttctagg aaatgtttga catctgaagc 2461 tctcttcaca ctcccgtggc actcctcaat tgggagtgtt gtgactgaaa tgcttgaaac 2521 caaagcttca gataaacttg caagataaga caactttaag aaaccagtgt taataacaat 2581 attaacag (2) INFORMATION FOR SEQ ID NO:2805: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2805 1 atcttatttt tctttttggt ggtggtggtg gaagggggga ggtgctagca gggccagcct 61 tgaactcgct ggacagagct acagacctat ggggcctgga agtgcccgct gagaaaggga 121 gaagacagca gaggggttgc cgaggcaacc tccaagtccc agatcatgtc tctgtggggt 181 ctggtctcca agatgccccc agaaaaagtg cagcggctct atgtcgactt tccccaacac 241 ctgcggcatc ttctgggtga ctggctggag agccagccct gggagtcct ggtcggctcc 301 gacgccttct gctgcaactt ggctagtgcc ctactttcag acactgtcca gcaccttcag 361 gcctcggtgg gagagcaggg ggaggggagc accatcttgc aacacatcag cacccttgag 421 agcatatatc agagggaccc cctgaagctg gtggccactt tcagacaaat acttcaagga 481 gagaaaaaag ctgttatgga acagttccgc cacttgccaa tgcctttcca ctggaagcag 541 gaagaactca agtttaagac aggcttgcgg aggctgcagc accgagtagg ggagatccac 601 cttctccgag aagccctgca gaagggggct gaggctggcc aagtgtctct gcacagcttg 661 atagaaactc ctgctaatgg gactgggcca agtgaggccc tggccacgct actgcaggag 721 accactggag agctagaggc agccaaagcc ctagtgctga agaggaccca gatttggaaa WO 00/09525 PCT/US99/17712 EPI-109 1070 781 cggcagcagc agctggcagg gaatggcgca ccgtttgagg agagcctggc cccactccag 841 gagaggtgtg aaagcctggt ggacatttat tcccagctac agcaggaggt aggggcggct 901 ggtggggagc ttgagcccaa gacccgggca tcgctgactg gccggctgga tgaagtcctg 961 agaaccctcg tcaccagttg cttcctggtg gagaagcagc ccccccaggt actgaagact 1021 cagaccaagt tccaggctgg agttcgattc ctgttgggct tgaggttcct gggggcccca 1081 gccaagcctc cgctggtcag ggccgacatg gtqacagaga agcaggcgcg ggagctgagt 1141 gtgcctcagg gtcctggggc tggagcagaa agcactggag aaatcatcaa caacactgtg 1201 cccttggaga acagcattcc tgggaactgc tgctctgccc tgttcaagaa cctgcttctc 1261 aagaagatca agcggtgtga gcggaagggc actgagtctg tcacagagga gaagtgcgct 1321 gtgctcttct ctgccagctt cacacttggc cccggcaaac tccccatcca gctccaggcc 1381 ctgtctctgc ccctggtggt catcgtccat ggcaaccaag acaacaatgc caaagccact 1441 atcctgtggg acaatgcctt ctctgagatg gaccgcgtgc cctttgtggt ggctgagcgg 1501 gtgccctggg agaagatgtg tgaaactctg aacctgaagt tcatggctga ggtggggacc 1561 aaccgggggc tgctcccaga gcacttcctc ttcctggccc agaagatctt caatgacaac 1621 agcctcagta tggaggcctt ccagcaccgt tctgtgtcct ggtcgcagtt caacaaggag 1681 atcctgctgg gccgtggctt caccttttgg cagtggtttg atggtgtcct ggacctcacc 1741 aaacgctgtc tccggagcta ctggtctgac cggctgatca ttggcttcat cagcaaacag 1801 tacgttacta gccttcttct caatgagccc gacggaacct ttctcctccg cttcagcgac 1861 tcagagattg ggggcatcac cattgcccat gtcatccggg gccaggatgg ctctccacag 1921 atagagaaca tccagccatt ctctgccaaa gacctgtcca ttcgctcact gggggaccga 1981 atccgggatc ttgctcagct caaaaatctc tatcccaaga agcccaagga tgaggctttc 2041 cggagccact acaagcctga acagatgggt aaggatggca ggggttatgt cccagctacc 2101 atcaagatga ccgtggaaag ggaccaacca cttcctaccc cagagctcca gatgcctacc 2161 atggtgcctt cttatgacct tggaatggcc cctgattcct ccatgagcat gcagcttggc 2221 ccagatatgg tgccccaggt gtacccacca cactctcact ccatcccccc gtatcaaggc 2281 ctctccccag aagaatcagt caacgtgttg tcagccttcc aggagcctca cctgcagatg 2341 ccccccagcc tgggccagat gagcctgccc tttgaccagc ctcaccccca gggcctgctg 2401 ccgtgccagc ctcaggagca tgctgtgtcc agccctgacc ccctgctctg ctcagatgtg 2461 accatggtgg aagacagctg cctgagccag ccagtgacag cgtttcctca gggcacttgg 2521 attggtgaag acatattccc tcctctgctg cctcccactg aacaggacct cactaagctt 2581 ctcctggagg ggcaagggga gtcgggggga gggtccttgg gggcacagcc cctcctgcag 2641 ccctcccact atgggcaatc tgggatctca atgtcccaca tggacctaag ggccaacccc 2701 agttggtgat cccagctgga gggagaaccc aaagagacag ctcttctact acccccacag 2761 acctgctctg gacacttgct catgccctgc caagcagcag atggggaggg tgccctccta 2821 tccccaccta ctcctgggtc aggaggaaaa gactaacagg agaatgcaca gtgggtggag 2881 ccaatccact ccttcctttc tatcattccc ctgcccacct ccttccagca ctgactggaa 2941 gggaagttca ggctctgaga cacgccccaa catgcctgca cctgcagcgc gcacacgcac 3001 gcacacacac atacagagct ctctgagggt gatggggctg agcagg (2) INFORMATION FOR SEQ ID NO:2806: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: _base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2806 1 gctttctcct agggactgtg aggggcgctt ctgactttgg acttgagcac tgcctgggac 61 ctgtgctgag agagcgctag catgtctcag tggaatcaag tccaacagtt agaaatcaag 121 tttttggagc aggtggatca attctatgat gacaactttc ccatggaaat tcggcatctg 181 ttggcccaat ggattgaaaa tcaagactgg gaggcagctt ctaacaatga aaccatggca 241 acgattcttc ttcaaaactt gttaatacaa ctggatgaac agttaggtcg tgtttccaaa 301 gagaaaaacc tactcttgat acacaatcta aaaagaatta ggaaggtcct tcagggaaaa 361 tttcatggaa atccaatgca tgtagctgtg gttatttcaa actgtttaag ggaagagagg 421 agaatattgg ctgcagccaa catgcctgtc caggggcctc tagagaaatc cttacaaagt 481 tcttcagttt cagaaagaca gaggaatgtg gagcacaaag tggctgccat taaaaacagt 541 gtgcagatga cagaacaaga taccaaatac ttagaagatc tgcaagacga atttgactac 601 aggtataaaa caattcagac aatggatcag agtgacaaga atagtgccat ggtgaatcag 661 gaagttttga cactgcagga aatgcttaac agcctcgatt tcaagagaaa ggaggctctc 721 agtaaaatga cccaaatcat ccatgagaca gacctgttaa tgaacaccat gctcatagaa 781 gagctgcaag actggaagcg gcggcagcaa atcgcctgca tcgggggtcc actccacaat 841 gggctcgacc agcttcagaa ctgctttaca ctattggcag aaagtctttt ccaactgaga 901 aggcaattgg agaaactaga ggagcaatct accaaaatga catatgaagg tgatcccatt 961 ccaatgcaaa gaactcacat gctagaaaga gtcaccttct tgatctacaa ccttttcaag 1021 aactcatttg tggttgagcg acagccatgt atgccaaccc accctcagag gccgttggta 1081 cttaaaaccc taattcagtt cactgtaaaa ctaaggctac taataaaatt gccagaacta 1141 aactatcagg taaaggttaa ggcatcaatt gacaagaatg tttcaactct aagcaaccga 1201 agatttgtac tttgtggaac taatgtcaaa gccatgtcta ttgaagaatc ttccaatggg 1261 agtctctcag tagaatttcg acatttgcaa ccaaaggaaa tgaagtccag tgctggaggt 1321 aaaggaaatg agggctgtca catggtgact gaagaacttc attccataac gtttgaaaca WO 00/09525 PCT/US99/177-12 EPI-109 101 1381 cagatctgcc tctatggcct gaccatagat ttggagacca gctcattgcc tgtggtgatg 1441 atttccaatg tcagtcagtt acctaatgct tgggcatcca tcatttggta caacgtgtca 1501 accaacgatt cccagaactt ggttttcttt aataatcctc cacctgccac attgagtcaa 1561 ctactggagg tgatgagctg gcagttttca tcgtacgttg gtcgtggtct taactcagat 1621 caactccata tgctggcaga gaagcttaca gtccaatcta gctacagtga tggtcacctc 1681 acctgggcca agttctgcaa ggaacattta cctggtaaat catttacctt ttggacatgg 1741 cttgaagcaa tattggatct aattaagaaa cacattcttc ccctttggat tgatgggtat 1801 gtcatgggct ttgttagcaa agagaaggaa cggctgttgc taaaggataa aatgcctggc 1861 acctttttat taagattcag tgaaagccat ctcggaggaa taactttcac ctgggtggac 1921 cattctgaaa gtggggaagt gagattccac tctgtagaac cctacaataa aggccggttg 1981 tctgctctgc cattcgctga catcctgcga gactacaaag ttattatggc tgaaaacatt 2041 cctgaaaacc ctctgaagta cctatatcct gacattccca aagacaaagc cttcggtaaa 2101 cactacagct ctcagccttg cgaagtttca agaccaacag aaaggggtga caaaggttat 2161 gttccttctg tttttatccc catctcaaca atccgaagtg attcaacaga gccacattct 2221 ccatcagacc ttcttcccat gtctccaagt gtgtatgcgg tgttgagaga aaacctgagt 2281 cccacaacaa ttgaaactgc aatgaagtct ccttattctg ctgaatgaca ggataaactc 2341 tgacgcacca agaaaggaag caaatgaaaa agtttaaaga ctgttctttg cccaataacc 2401 acattttatt tcttcagctt tgtaaatacc aggttctagg aaatgtttga catctgaagc 2461 tctcttcaca ctcccgtggc actcctcaat tgggagtgtt gtgactgaaa tgcttgaaac 2521 caaagcttca gataaacttg caagataaga caactttaag aaaccagtgt taataacaat 2581 attaacag 1 gctttctcct agggactgtg aggggcgctt ctgactttgg acttgagcac tgcctgggac 61 ctgtgctgag agagcgctag catgtctcag tggaatcaag tccaacagtt agaaatcaag 121 tttttggagc aggtggatca attctatgat gacaactttc ccatggaaat tcggcatctg 181 ttggcccaat ggattgaaaa tcaagactgg gaggcagctt ctaacaatga aaccatggca 241 acgattcttc ttcaaaactt gttaatacaa ctggatgaac agttaggtcg tgtttccaaa 301 gagaaaaacc tactcttgat acacaatcta aaaagaatta ggaaggtcct tcagggaaaa 361 tttcatggaa atccaatgca tgtagctgtg gttatttcaa actgtttaag ggaagagagg 421 agaatattgg ctgcagccaa catgcctgtc caggggcctc tagagaaatc cttacaaagt 481 tcttcagttt cagaaagaca gaggaatgtg gagcacaaag tggctgccat taaaaacagt 541 gtgcagatga cagaacaaga taccaaatac ttagaagatc tgcaagacga atttgactac 601 aggtataaaa caattcagac aatggatcag agtgacaaga atagtgccat ggtgaatcag 661 gaagttttga cactgcagga aatgcttaac agcctcgatt tcaagagaaa ggaggctctc 721 agtaaaatga cccaaatcat ccatgagaca gacctgttaa tgaacaccat gctcatagaa 781 gagctgcaag actggaagcg gcggcagcaa atcgcctgca tcgggggtcc actccacaat 841 gggctcgacc agcttcagaa ctgctttaca ctattggcag aaagtctttt ccaactgaga 901 aggcaattgg agaaactaga ggagcaatct accaaaatga catatgaagg tgatcccatt 961 ccaatgcaaa gaactcacat gctagaaaga gtcaccttct tgatctacaa ccttttcaag 1021 aactcatttg tggttgagcg acagccatgt atgccaaccc accctcagag gccgttggta 1081 cttaaaaccc taattcagtt cactgtaaaa ctaaggctac taataaaatt gccagaacta 1141 aactatcagg taaaggttaa ggcatcaatt gacaagaatg tttcaactct aagcaaccga 1201 agatttgtac tttgtggaac taatgtcaaa gccatgtcta ttgaagaatc ttccaatggg 1261 agtctctcag tagaatttcg acatttgcaa ccaaaggaaa tgaagtccag tgctggaggt 1321 aaaggaaatg agggctgtca catggtgact gaagaacttc attccataac gtttgaaaca 1381 cagatctgcc tctatggcct gaccatagat ttggagacca gctcattgcc tgtggtgatg 1441 atttccaatg tcagtcagtt acctaatgct tgggcatcca tcatttggta caacgtgtca 1501 accaacgatt cccagaactt ggttttcttt aataatcctc cacctgccac attgagtcaa 1561 ctactggagg tgatgagctg gcagttttca tcgtacgttg gtcgtggtct taactcagat 1621 caactccata tgctggcaga gaagcttaca gtccaatcta gctacagtga tggtcacctc 1681 acctgggcca agttctgcaa ggaacattta cctggtaaat catttacctt ttggacatgg 1741 cttgaagcaa tattggatct aattaagaaa cacattcttc ccctttggat tgatgggtat 1801 gtcatgggct ttgttagcaa agagaaggaa cggctgttgc taaaggataa aatgcctggc 1861 acctttttat taagattcag tgaaagccat ctcggaggaa taactttcac ctgggtggac 1921 cattctgaaa gtggggaagt gagattccac tctgtagaac cctacaataa aggccggttg 1981 tctgctctgc cattcgctga catcctgcga gactacaaag ttattatggc tgaaaacatt 2041 cctgaaaacc ctctgaagta cctatatcct gacattccca aagacaaagc cttcggtaaa 2101 cactacagct ctcagccttg cgaagtttca agaccaacag aaaggggtga caaaggttat 2161 gttccttctg tttttatccc catctcaaca atccgaagtg attcaacaga gccacattct 2221 ccatcagacc ttcttcccat gtctccaagt gtgtatgcgg tgttgagaga aaacctgagt 2281 cccacaacaa ttgaaactgc aatgaagtct ccttattctg ctgaatgaca ggataaactc 2341 tgacgcacca agaaaggaag caaatgaaaa agtttaaaga ctgttctttg cccaataacc 2401 acattttatt tcttcagctt tgtaaatacc aggttctagg aaatgtttga catctgaagc 2461 tctcttcaca ctcccgtggc actcctcaat tgggagtgtt gtgactgaaa tgcttgaaac 2521 caaagcttca gataaacttg caagataaga caactttaag aaaccagtgt taataacaat 2581 attaacag 1 atcttatttt tctttttggt ggtggtggtg gaagggggga ggtgctagca gggccagcct 61 tgaactcgct ggacagagct acagacctat ggggcctgga agtgcccgct gagaaaggga 121 gaagacagca gaggggttgc cgaggcaacc tccaagtccc agatcatgtc tctgtggggt WO 00/09525 PCT/US99/17712 EPI-109 1072 181 ctggtctcca agatgccccc agaaaaagtg cagcggctct atgtcgactt tccccaacac 241 ctgcggcatc ttctgggtga ctggctggag agccagccct gggagttcct ggtcggctcc 301 gacgccttct gctgcaactt ggctagtgcc ctactttcag acactgtcca gcaccttcag 361 gcctcggtgg gagagcaggg ggaggggagc accatcttgc aacacatcag cacccttgag 421 agcatatatc agagggaccc cctgaagctg gtggccactt tcagacaaat acttcaagga 481 gagaaaaaag ctgttatgga acagttccgc cacttgccaa tgcctttcca ctggaagcag 541 gaagaactca agtttaagac aggcttgcgg aggctgcagc accgagtagg ggagatccac 601 cttctccgag aagccctgca gaagggggct gaggctggcc aagtgtctct gcacagcttg 661 atagaaactc ctgctaatgg gactgggcca agtgaggccc tggccatgct actgcaggag 721 accactggag agctagaggc agccaaagcc ctagtgctga agaggatcca gatttggaaa 781 cggcagcagc agctggcagg gaatggcgca ccgtttgagg agagcctggc cccactccag 841 gagaggtgtg aaagcctggt ggacatttat tcccagctac agcaggaggt aggggcggct 901 ggtggggagc ttgagcccaa gacccgggca tcgctgactg gccggctgga tgaagtcctg 961 agaaccctcg tcaccagttg cttcctggtg gagaagcagc ccccccaqgt actgaagact 1021 cagaccaagt tccaggctgg agttcgattc ctgttgggct tgaggttcct gggggcccca 1081 gccaagcctc cgctggtcag ggccgacatg gtgacagaga agcaggcgcg ggagctgagt 1141 gtgcctcagg gtcctggggc tggagcagaa agcactggag aaatcatcaa caacactgtg 1201 cccttggaga acagcattcc tgggaactgc tgctctgccc tgttcaagaa cctgcttctc 1261 aagaagatca agcggtgtga gcggaagggc actgagtctg tcacagagga gaagtgcgct 1321 gtgctcttct ctgccagctt cacacttggc cccggcaaac tccccatcca gctccaggcc 1381 ctgtctctgc ccctggtggt catcgtccat ggcaaccaag acaacaatgc caaagccact 1441 atcctgtggg acaatgcctt ctctgagatg gaccgcgtgc cctttgtggt ggctgagcgg 1501 gtgccctggg agaagatgtg tgaaactctg aacctgaagt tcatggctga ggtggggacc 1561 aaccgggggc tgctcccaga gcacttcctc ttcctggccc agaagatctt caatgacaac 1621 agcctcagta tggaggcctt ccagcaccgt tctgtgtcct ggtcgcagtt caacaaggag 1681 atcctgctgg gccgtggctt caccttttgg cagtggtttg atggtgtcct ggacctcacc 1741 aaacgctgtc tccggagcta ctggtctgac cggctgatca ttggcttcat cagcaaacag 1801 tacgttacta gccttcttct caatgagccc gacggaacct ttctcctccg cttcagcgac 1861 tcagagattg ggggcatcac cattgcccat gtcatccggg gccaggatgg ctctccacag 1921 atagagaaca tccagccatt ctctgccaaa gacctgtcca ttcgctcact gggggaccga 1981 atccgggatc ttgctcagct caaaaatctc tatcccaaga agcccaagga tgaggctttc 2041 cggagccact acaagcctga acagatgggt aaggatggca ggggttatgt cccagctacc 2101 atcaagatga ccgtggaaag ggaccaacca cttcctaccc cagagctcca gatgcctacc 2161 atggtgcctt cttatgacct tggaatggcc cctgattcct ccatgagcat gcagcttggc 2221 ccagatatgg tgccccaggt gtacccacca cactctcact ccatcccccc gtatcaaggc 2281 ctctccccag aagaatcagt caacgtgttg tcagccttcc aggagcctca cctgcagatg 2341 ccccccagcc tgggccagat gagcctgccc tttgaccagc ctcaccccca gggcctgctg 2401 ccgtgccagc ctcaggagca tgctgtgtcc agccctgacc ccctgctctg ctcagatgtg 2461 accatggtgg aagacagctg cctgagccag ccagtgacag cgtttcctca gggcacttgg 2521 attggtgaag acatattccc tcctctgctg cctcccactg aacaggacct cactaagctt 2581 ctcctggagg ggcaagggga gtcgggggga gggtccttgg gggcacagcc cctcctgcag 2641 ccctcccact atgggcaatc tgggatctca atgtcccaca tggacctaag ggccaacccc 2701 agttggtgat cccagctgga gggagaaccc aaagagacag ctcttctact acccccacag 2761 acctgctctg gacacttgct catgccctgc caagcagcag atggggaggg tgccctccta 2821 tccccaccta ctcctgggtc aggaggaaaa gactaacagg agaatgcaca gtgggtggag 2881 ccaatccact ccttcctttc tatcattccc ctgcccacct ccttccagca ctgactggaa 2941 gggaagttca ggctctgaga cacgccccaa catgcctgca cctgcagcgc gcacacgcac 3001 gcacacacac atacagagct ctctgagggt gatggggctg agcagg (2) INFORMATION FOR SEQ ID NO:2807: (1) SEQUENCE CHARlACTERISTICS: (A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2807 1 tttattttta atttaatcac ttaattttta atttttaaga tggagtctca ctctgttgcc 61 caggctgaag tgcaagggtg taatctcagc tcactgcagc ctctgcctcc cggattccag 121 tgattttcct gcttcagctt cccaggtagc tgggattgca ggcacatgcc actgtgccca 181 gataattttt tgtatttttt agtagagacg gggcttcacc atgttggcca ggctggtctt 241 gaactcctaa cctcagatga tccgcacacc tcggcctccc aaagtgctag gattacaggc 301 atgagcctct gcgcctggcc tttacttcag tttcaaagag tgaaggtcaa gacactgttt 361 ttttttatgt tttgttttta attttgtttt aaattttttt tgtagagatg ggatcttgct 421 atgttgccca ggctggtctc gaactcctgg cctccagcaa tcctcctgcc tcagcctccc 481 agagtattgg gattacaggt gtgagccatt gtgcttgatc aagatgccgt tatgggctga 541 gttgtgttcc tcaaaaattc tcttgaagtc ctaatctcaa gtacttcagg acgtgacctt 601 attttgaagg acccccttat agggtcttta cagaggtaat taagttaaaa tgaggccatt 661 aggatggggc ctaatgcaat atgactggta tccttgaaaa aaggggaaac ttggagactg 721 acttgcatac aaagagaaca gtgtgtgaac gtgaaaatgg ccaaggaggg aggcctggaa WO 00/09525 PCTIUS99/17712 EPI-109 1073 781 tagagccttc cttcacatcc ctgagaagga atcaatcaat cctgctcagg ttaacctizga 841 tcttggactt ctagcctcca gcatcttgag agatttctgt tgtttaagtc atgcaatatg 901 tagtactttg ttacagcagc cctagcaaac tgatacactc accaaatcga ttttgtgact 961 cactattggg ttgtaaccag cagtacatag acataaagtt attttttcct tacgctttat 1021 cttgtgcaat cgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgacgg 1081 agtcttgttc tgtcaccagg ctggagtgca gtggcttgat ctcggctcac tataatcaca 1141 gccttccaga ttcaagtgat ttccctgcct cagcctcctg agtagctggg actacaggcg 1201 cgcaccacca cgcccgacta attttttgta tttttagtag agacggggtt tcaccatgtt 1261 ggccaggatg gtctcaatct cctgaccttg tgatctgcct gcctcagcct cccaaagtgc 1321 tgggattaca ggcgtgagcc tctcttgtgc aatctttacc accactcaat gggatgtcaa 1381 ggtccagggg agggtgatac agtcaccctc acagtcatgc aggtgcagat gtcattaatg 1441 aaggtctgac agaccctgca attgtacaat ctgaagatga gtatctcctt aaatttcata 1501 ctctaggcac tttaccctag cctagactct gttgaagtag gtataactat tattctcatt 1561 tgagggattg acacctgatt gtgaacctcc taaatgqagt catacccaag ccagatttgc 1621 ctctaaattc tgttttttcc ccttacatca cagtgttccc attggtatag tcagttacag 1681 agggagtaat atatactatt tttctaccag tacttgctcc tcgccttcct accccctaaa 1741 aggagccaaa gtcagagatc acatttactc ttttccctcc tcctctccaa gtctttgggg 1801 acttgtagct ctgacaccct tagatggtga aacctggctt cacctactgt ctgtggatgt 1861 ctgcaggcag agtgggcact caggagcaca tacaaagcac gtgtgccgtg aacacgtatg 1921 tgcacacacc ttgatcctag catggcttgt tggacaagcc aatggacaga gtccctgcct 1981 gccacctcca cccctgctct cccttctctt ccattcactg tcctgcagac acagcaaaca 2041 catacgcaca tacaccctca atatcctttt ggcagtaaca tgacccccaa atctggggac 2101 ttctatgtag gatggagacc cttctccttt cctcatacct ggtttattat gaaccataaa 2161 aatagtgcct gacagttact gtgtgtcagg cattgttcta agccttcaga tgttttactg 2221 cattttattc tcacattatg ggttaagact tatttgctcc attttacaga tgacgagaat 2281 gaatcacaga gtaaattgct cagggttgtg tggttagcag cattagcagg atttgaaccc 2341 aagcagcctg tatccacagt ccagtctttt aactgctata ttttgctgtg ttcaaaccct 2401 ctgctgcctg gctgggtcca cacacgtgca ctcatgcaca gacctgcggg gtagcaaggg 2461 atggaggagg aggagctggt tctggaaatc aattcaggca ccagggggca gcataggcct 2521 agctttggcc cctcagccca gcccctgcta tgggagggag gaggggagta gaaacttcct 2581 cccaccgccc ctcagacacc acctcttcca cacaccgggg ctctcaggtg tccgggagta 2641 aaggcctctc tggatccctt ggtctcctcc agctcctccc ccagcaaaaa ctgcagaacc 2701 ctccactagt tatgttgatg actcagaagt tgagcaagac tgtgtgtgtg tgtgtgtgtg 2761 tgtgtgtgtg tgtgtgtgtg tgtgtgtggt gttgtgattg caatgggctc tgtttgtgag 2821 cctgcctgca cgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtagtcttg tggtcaggga 2881 agttgtgcat gtgtgtgttt gtttcttggc gtgtctcagt gtttacccca gaaacatata 2941 ggaacttggc agataggaac acagcagatt cgtattcaaa cttgcccctt gtgaatctgc 3001 aggcagcagc tccggcttgt gctggttccc accacagtct caggaggggt gccctgtgag 3061 gagagagcaa agaccagctt cagtccaagg gactoctaga gtcttccaga attctgagct 3121 gagggttccc ctcccccact ccctcccgtc agtggtcacg agaccgacct ctaaggcgtt 3181 ccctgccgga agggaggggg acctaggagt tggctggcat cgagctccct ggcggctttt 3241 tagggtcctc cactggaggg agcgcagagt ccagagggat ttacttttcc tgaggccctg 3301 gggagcccag tcccttgtgg gtccaaaccc cagcccttgg cagagtttga gtttgggagc 3361 caggcagtta ggggtggcaa atctctgttt gatattgggt gactttctgg agaaaagctg 3421 atgcttttga gggggacaga gtaagtgggg gtcagcctcc ccccaagcct ggctccaagg 3481 cctggacccc agtcctgatc ccccacgtgt tcccccactc ggcacaggag gcacacatat 3541 tcaccccact ttcttcctct tcctcctcca gcccactttc tcttctctgt gtcgtcagag 3601 ctccagggag ggacctgggt agaaggagaa gccggaaaca gcgggctggg gcagccactg 3661 cttacactga agagggagga cgggagagga gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt 3721 atgtatgtgt gtgctttatc ttatttttct ttttggtggt ggtgttggaa ggggggaggt 3781 gctagcaggg ccagccttga actcgctgga cagagctaca gacctatggg gcctggaagt 3841 gcccgctgag aaagggagaa gacagcagag gggttgccga ggtgaggggt tgcctccgag 3901 gtgggtgcgg gggcctctat gagtgcatgg gggtggattc gtggggggag ctctcgggat 3961 cctcccctgg ctgggtggat ggtccccaan gagatggttt cagctantgt tggtggctgg 4021 tggcactggg ttttancagt ttcgaactcc tggaggaact gggagggtcc aggcctcant 4081 actcccetcc cccatgggtc acgttttcac agcctcaccc ctgcaccccc aagggcccat 4141 ggaaagtcag ggaaaggagg tgaaggagtg cccctctgcc ctgagtcggg ggaagtggcc 4201 gcccctccct ggaaggttga tcgcagaggg cagtggatcc ttgttaaacc cctatcctgc 4261 cctccactaa aggttcctgt tcaagggtgt ggctggggcg tgagcaagcc ccagatgtag 4321 acctcatggt ggcccagacg agggggaatt tccccctcaa aactgctcca cgcttggctc 4381 gtgtagacgc tgagatttcc cagcggcggc gccgaattaa ccctcctcgt gctgaactgg 4441 ctccacctcc ccgccttgcc cccaccgcca cattcacgca ttgggcaact cagagaagat 4501 gttttaactt tcgatcctgt ggtccacaat gagaggactc gggcagatag gggttgagat 4561 aagcgagttt aggccaccaa gcgggcggac gaggatccca gaccttgcgc ttcccttctg 4621 agtttgggag gtaacactgg ccccgcccct cacgccgtgg ctcctccctc ccttcccctt 4681 caaggggctg aagacaaaag gtgcccctgt cctggtcaag ccaatcgacc cagccttgtt 4741 atgggttggg gtggggaaaa atgagtcctc ctgatggctg gggaagaaga ggggttggat 4801 atttctagcc agggccatgc caggaggctg gtcactctgc aaggggatgc agaggaaagc WO 00/09525 PCT/US99/17712 EPI-109 1074 4861 ggagcccact cactccagag gacctttctc ttcttgggct agagaaaggc ctattggagg 4921 aacctgagca ggaggggtaa ggattctgcc ttgaggagaa aagagctggg gtaagtgggc 4981 actggaggaa agaggggcat gaaggtcttg gagcagaaac gtccagagaa gggacctctc 5041 cattttccat ccctctgaga ggcctgggag aggtgagagg ctgaacgtgc aacaggagga 5101 cttggggtta ctgggtttgg ggagacctgg ggagttgtca tcccatcctc tccctcatct 5161 ctgggagagg gatattatga gaaacgtgaa ctgagaggcc cctgggaaac cactggttac 5221 ccagtcctcc ctgaacctgg aaatggggat gcaaccccct cttctacttc cctgtcccct 5281 cctctccttt ctacctgttt tcgtctctca tctttgcctt ctagccctcc agcttcctct 5341 ctcttctagg ctctttcctc ctagcttact aaacccgcct tttttccagt ctcttccatc 5401 ctcttcctta gttctctcta ctttcctttt ccacctctcc tccttcaagt ctcctcccac 5461 cttcccccac ttcttaggat gatcagattt gcccctggaa gggatcctaa caacacagtg 5521 cgatggttaa tccccactca gattcaaagc ctgctttcca aactcactta ctgagtggcc 5581 ttgggcagag tagagaaact ccttaagcct cagtttcttc atctataaaa tgggatatta 5641 tatattttaa aaagtgtcgt gaggcctgaa ggagataata cactgagtgt aatgcctcat 5701 acacagtaag tgcttaacaa atagtagctg ttattactct cccatcctct tcatcatcta 5761 gccttgtggt tttcattttt attttatttc atttatttat ttatttattt tgagcagagt 5821 ctctctctgt cgcccaggct ggagtgcagt ggctcgatct ctgctcactg caagctccgc 5881 cccccaggtt cacgccattc tgtcacctca gcctccccag tagctgggag tacaggcgct 5941 cgccaccacg ccctgctaat tttgtttttg tatttttagt agagatgggg tttcactgtg 6001 ttagccagga tggtcttgat ctcctgacct cgtgatctgc ccgcctcggc ctcccaaagc 6061 gctgggatta caggcatgag ccactgcgcc tggccgagcc ttgtggtttt caaattatct 6121 catggagtcc tagaattttg agaggtttgt ctagggatgc ctttggcgtc aggaggtggg 6181 gagagggaag tagaagcagt cgagtttcag gctttccatg cttgctttca acagggcatc 6241 ttcggtttcg taccttttat gtaattgaga ttccacagat taaaagctga cattgcctac 6301 cgctttaaaa agtttggaaa gttttccact catctaacac tcatatttta tagatgagaa 6361 gatcgaagcc cacaaaggga aggctctttg cccacagaac cagagccagg tctagagctg 6421 caactaaatc ctctgccact ctaagagagc tctcgctcta ctgccctgtc tccctttgcc 6481 tccccatccc tctggctaca gctcagctct tcccacccct gtgtctatca ctgaaggagt 6541 tacccccatc tcaggcattg actcaggatg cccctggttt aaggtggtct ggccatgagt 6601 ggtggtgggg acggtcccta ggagggctat ctatgggagg tcccctggct gccccaggag 6661 ataggccaag tttctttggg cacccctcag agtggcctta tttttttcct ccaggcaacc 6721 tccaagtccc agatcatgtc tctgtggggt ctggtctcca agatgccccc agaaaaagtg 6781 cagcggctct atgtcgactt tccccaacac ctgcggcatc ttctgggtga ctggctggag 6841 agccagccct ggtgagtcct ggctgctccc tgctggtccc ccaagtcttc cctaactcat 6901 cttccttctc cttagatttt tctcccctca cccatggatt cagaacttga gacctgttat 6961 tccatgtgta gtgacctaga tttagcaggg agtctgtgcc ccatcaagac caggctatga 7021 atgttgacag atggagaccc ccatctctta ggaggctgag ccgaagagga ggggggtttg 7081 ggctgggaca aaggcacttc tcataacagc tagaagactg ggaaacaagg cgcatgggtg 7141 aaagctacag agggcctaga tggagaataa ggagcgagaa aggaatgctg acttttggct 7201 gtggggtaaa ggtcaggaaa ctgaagaagc ctggcctgaa gtacctctcc tgatcttcct 7261 gcaagggagt tcctggtcgg ctccgacgcc ttctgctgca acttggctag tgccctactt 7321 tcagacactg tccagcacct tcaggcctcg gtgggagagc agggggaggg gagcaccatc 7381 ttgcaacaca tcagcaccct tgaggtgggg caggagggga ggggacaagg ctgggtgggg 7441 ctgaggttga actgggttga gcattgggcc ctggaagaaa attggttgga tgctggaagc 7501 aaattggtgt tcctgtggtt aactgctagc tagcaggcaa attagatttt aaaagcatgc 7561 aaatgcacaa aaacttctgg agtctacagt tgtgcttcct tatagtatat gtgtgaatgc 7621 aggcctgggg attggaggga ttgaaggaca tgggtaagag caaagctcac tgtttaccac 7681 cctcatttct gtagagcata tatcagaggg accccctgaa gctggtggcc actttcagac 7741 aaatacttca aggagagaaa aaagctgtta tggaacaggt attgtgatat tccacctccc 7801 accccaactc aatcccctga gactttggcc tgagccatga caaactagaa agaatttgat 7861 cctcagaaaa ggctcagtgt tctaggccca ggaatgacca aaggaggttc ctagggtcag 7921 agtgaacccc aagtcaagct cagggaatct ttctatgagg gactgaaggt aagaggccgq 7981 ggagaacaga gcaagggata aggagctgat tctgctagqa gcaaggtctt atctccacga 8041 tattccaaaa ggtcaggaag aactgccaaa ggggagaggg gaacaagaaa acgctatatg 8101 cagagcagag agtggaggcc aggtatagag ggatgagcag agtgtttgag ttcttggcat 8161 ctgtccttcc tgtgtagttc cgccacttgc caatgccttt ccactggaag caggaagaac 8221 tcaagtttaa gacaggcttg cggaggctgc agcaccgagt aggggagatc caccttctcc 8281 gacaagccct gcagaagggg gctgaggctg gccaaggtgg gggccagggt ggttctgggg 8341 agtgtgtaag agtggttgcc tcttggatct caaccttatc tgaacctcta atctgtctgc 8401 acccttgatt tctgccccca accctcagtg tctctgcaca gcttgataga aactcctgct 8461 aatgggactg ggccaagtga ggtgagtaat gggctgacag gtggagacct tggtcaaagt 8521 gcagctggag ggatggaagc tagacctcag aaagacacag gctgaagtag ggcaagggaa 8581 tgccagagga gtgagaaaaa gaccgtatcc caggagctgg gtgtggaggc agcgtgaggc 8641 cctggctcag gcccctctct gcccataggc cctggccatg ctactgcagg agaccactgg 8701 agagctagag gcagccaaag ccctagtgct gaagaggatc cagatttgga aacggcagca 8761 gcagctggca gggaatggcg caccgtttga ggagagcctg gccccactcc aggagaggtt 8821 gggctagggc tgatggggaa gagggggcaa gctgggggtg ggcagctgac cctgctgaag 8881 gccctacagg tgagagaaag aagccaggcg ggagggcctt ggcagtggac caagatgcat WO 00/09525 PCT/US99/17712 EPI-109 1075 8941 aaaagccagt tccagcgggg ctgtgcacac tgtcgttcag gtcgcatcct gtacaagtgg 9001 gcctagtgga ggggcacaag cggggactca tccaacccag gcttctctcc tcaagcccca 9061 tgcctagagg aataggaggg cttttccatt tggtttattg ggtgggaaca cttcccaatt 9121 tgccacaaag cactgtaagt ggtggcagtt gttcttgggt gcaagaaccg tcggggagag 9181 gcagctgggt ttccacaggg ggtgtaggca actgataatg aacctcccac ccacacccta 9241 ggccaacaga tcacagaacc ccttcagccc aggtgccttg cagccacacc cactacccac 9301 cccacttctc cacacatgat agcctttctc cctgggtata ggggaagggg gtctgggccg 9361 gagcaagcag ccttaatcct gtgccccctg accactgtcc tggccccagg tgtgaaagcc 9421 tggtggacat ttattcccag ctacagcagg aggtaggggc ggctggtggg gagcttgagc 9481 ccaagacccg ggcatcgctg actggccggc tggatgaagt cctgagaacc ctcgtcacca 9541 ggtattcccc gggagctccc agtctggcct agaacagacc tcgggaagaa aagaaggggg 9601 ctagagctgt ggggagggca ccagcaggga cctagccccc aactcccctt gtgtcctcct 9661 cactcccagt tgcttcctgg tggagaagca gcccccccag gtactgaaga ctcagaccaa 9721 gttccaggct ggagttcgat tcctgttggg cttgaggttc ctgggggccc cagccaagcc 9781 tccgctggtc agggccgaca tggtgacaga gaagcaggcg cgggagctga gtgtgcctca 9841 gggtcctggg gctggagcgt aagctgggat tggacctggg gttggagaag ggctgttagg 9901 gtqatggagg cagcctggag ggctggcact gaaaagagca agggatgggg agggagggcc 9961 atgggatgtg gagaccctga atggtcaagg cagaggaaag ggagggaccc atttagggct 10021 ggaatggggt gggggcatca tgatttggcc aagatgggga ctcctccctt aagaacccaa 10081 acagagacat ggagacttag ggctggtgac agtgggtagt ctacactcac ccatgcactc 10141 gccacacctg acgacagtga gatgagctcg ttcacactct gacctcccct gggcagagaa 10201 agcactggag aaatcatcaa caacactgtg cccttggaga acagcattcc tgggaactgc 10261 tgctctgccc tgttcaagaa cctggtgagg ggctttgggg tgcagtgagg ggggcaccac 10321 taggagactg tgggactctc cttggagagg atgtcaggaa gcccaggagg agcggtctct 10381 gtcctcatga cctcgccctt gctctccctc accccaccca cagcttctca agaagatcaa 10441 gcggtgtgag cagaagggca ctgagtctgt cacagaggag aagtgcgctg tgctcttctc 10501 tgccagcttc acacttggcc ccggcaaact ccccatccag ctccaggtga accgtggccc 10561 agccctgccc caatctggga ccccgagtcc tcctccaatg ccacgcacaa gggccctgga 10621 ccctcacctc ttgtgactgc cccatacccc atgtgtctgg gattcatgca cactggggcc 10681 cgggtgagtg ggggtgagca agagcatgga gtgcacaggg cagggaatgg tagtggatag 10741 cagcaaacac ttcggaagca cttcctatag accaggggca ctctattaaa tgatacatac 10801 tgcacatgcg tgccagcaca cacacgtctg gttttcacaa taacattatg aggtaggcag 10861 tattatcagc ctcattttat agcatgagga cattgagaca gagagtttaa gtagtttgtc 10921 ccagtcaccc agctaagtgt tggagctggt atctgaaacc tggaagtctg gttccatagc 10981 gattatagta accacttctc tacggtgagg ccctgattga gcttcaaaac gcatttaata 11041 acatgg (2) INFORMATION FOR SEQ ID NO:2808: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: _base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2808 1 ggaaagaaag aaagaaaaga aaccctgtcc tcaccctact tcaggccctg tctctgcccc 61 tggtggtcat cgtccatggc aaccaagaca acaatgccaa agccactatc ctgtgggaca 121 atgccttctc tgagatggtg aggaaagtcc ttggtagttg gagggaacag ggtgcagggt 181 gggttctaac atgggcagtg gtgcaggcct gctgatgggg tggtgggcat gtcggatggg 241 tgtgacctta acacttcttc atgggcctgc tttcgtgctt ctgacctctt ttcaccccag 301 tcttaacaac tatcaggcca cagcactgta acctagaaaa aacagcatgt ttgtgagcga 361 tatcaggggc tgtggagggg taggccacag gcatgtggga cggatgaagg ccggcccgag 421 gaataacaag acggtagcct gcagtgctct cttcttcccc cttctcccca ggaccgcgtg 481 ccctttgtgg tggctgagcg ggtgccctgg gagaagatgt gtgaaactct gaacctgaag 541 ttcatggctg aggtggggac caaccggggg ctgctcccag agcacttcct cttcctggcc 601 cagaagatct tcaatgacaa cagcctcagt atggaggcct tccagcaccg ttctgtgtcc 661 tggtcgcagt tcaacaaggt tcagttctcc (2) INFORMATION FOR SEQ ID NO:2809: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: _base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2809 1 gcggccgcga gctctaatac gactcactat agggcgtcga ctcgatcata ccactgcact 61 caagcctggg tgacagagca agactctgtc tcaaaaaaaa aaaaaaaaaa aggccaggca 121 tggtggttca tgcctgtaat cccagcactt tgggaggccg agacggatag atcacctgag 181 gtcaggagtt cgagaccagc ctggccaaca tggcaaaacc ccgtctctac taaaaacaaa 241 aaaatagcca ggatggtcg ttgcgtctgt aatcccagct actcggctga ggcaggaggt WO 00/09525 PCT/US99/17712 EPI-109 1076 301 gaacccagga ggtaaaggct gcaggggaag atgaaaccat tgcactccag cctgggcaag 361 actctgtatc aaaaaaaaaa aaaaaaaggc taggtgtggt ggctcacacc tgtaatccca 421 gcactttggg aggctgaggc gggcggatca caaggtcaag aaatcgagac catcctgacc 481 aacatggtga aaccccgtct ctactaaaaa tacaaaaatt acctgggcat ggtggcgcat 541 gcctgtattc ccaactactc gggaggctga ggcatgaaaa tcacttgaac ctgggaggca 601 gaggttgcag gcgagccaag attgtgccac tgcactccag cctgccaaca aaaatgagat 661 tctgtc (2) INFORMATION FOR SEQ ID NO:2810: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2810 1 ggttaccttc cctttgggcg tcaacttctg ccacacctcc ttagggagag ggtgtagcat 61 agtagttaag aggggtccag ggccagaatg cctgggttta aatcctagct ctgcctctta 121 ccagctatgt agacctgggc aagtcattcg acgtttttgg acttccattt cttcatctgt 181 aagatggaat tattataatc cctacttcca tagcctggta aagagcaaat aaatatatgg 241 aaaggcttga aatagtggct ggcacgtgta agcattagga ttggtcgttg tcattgatgg 301 agtctcaggt tcggtctgat cctcagcccc tgtgattctg tcgtgagggc actcacagct 361 cactgcctgc cctaaacagg ctccagctct ggccctccct cggctcacac ctttccccct 421 ctccccctag gagatcctgc tgggccgtgg cttcaccttt tggcagtggt ttgatggtgt 481 cctggacctc accaaacgct gtctccggag ctactggtct gaccggtgag tccccaccct 541 gggtagtttg agcagccata caccagtcac ctccatactc actgcccatg ccccatcctc 601 tccttcatcc cggccaggct gatcattggc ttcatcagca aacagtacgt tactagcctt 661 cttctcaatg agcccgacgg aacctttctc ctccgcttca gcgactcaga gattgggggc 721 atcaccattg cccatgtcat ccggggccag gatggtgagg ccaccccagc cagtcctctg 781 tctctgtgcc tgtgccctct ggggtttctt ctgggaatga aatgtcctga ccttcctgat 841 gccgatcctg atcttcagga agttcttcca gcttctcttc ttccttctgt ggtctaaatg 901 ttcaccttct cactgtgagc tctgtgggaa cggagactag tgggtctctc tccctcagga 961 gccccaccct aggtcctctc tcccttgcct tggtggagtg agaacaggtc ttatggtagg 1021 ggttggggaa ggggaagaaa tccggacaga gggatctcag ggtctccttc ctaccatagg 1081 ctctccacag atagagaaca tccagccatt ctctgccaaa gacctgtcca ttcgctcact 1141 gggggaccga atccgggatc ttgctcagct caaaaatctc tatcccaaga agcccaagga 1201 tgaggctttc cggagccact acaagcgtga gctggaactg gcagctctga ttccttcctg 1261 tcacccactt cctgccatgc tccccgctgc catcctctcc ccagcccgtg agttatcctg 1321 aggtcactcc gaatttccat agctgtgctt ttcttacttc ccggatgatc catgcccacc 1381 ttttccacct cccttcctcc ctaacccgag agcaatccat ggcagtcttt tccatctcac 1441 aacagctgaa cagctgaaca gatgggtaag gatggcaggg gttatgtccc agctaccatc 1501 aagatgaccg tggaaaggtg agtgtggtgg tatggacagt gggtaggtca ggggcttagt 1561 gcttatctgc aggaaggagg ggtggcatca acccttggtc agtcacatgt acctccttcc 1621 ctcctccagg gaccaaccac ttcctacccc agagctccag atgcctacca tggtgccttc 1681 ttatgacctt ggaatggccc ctgattcctc catgagcatg cagcttggcc cagatatggt 1741 gtaaggagct ggaaagacag gaatgggagt ggtctgtgca gatgggctaa tcttagcatg 1801 ggcagctggg agagctggca ctgggggctg aacagggaat cttcctttcc atgagaggga 1861 cacctgttca aaagcagggt gtggtggtgt ccaggagaag ggctggcatc agggggtctg 1921 ttttctttcc ccaggcccca ggtgtaccca ccacactctc actccatccc cccgtatcaa 1981 ggcctctccc cagaagaatc agtcaacgtg ttgtcagcct tccaggagta agtgaaaaac 2041 ctcatgggga taccatccca ctctaagggg gtgggcattt gaattgttag aagaggctct 2101 tctgtgagaa aggagcagca aatgctaaca gcctgtcttc ttctcttctg tccactctaa 2161 tgagggggta gtagttaaga tctggactgc ctaggtttga attctagctc caccacttac 2221 tggtttgggg caaattactt agcctttggt gccttatctg cacaatgggg gataataatg 2281 ctaataataa taacctacct cactgcatta ttgtggagat taaatgagtt cataacactt 2341 aaaaagctcg agcatagtgc atggctcata gcaaaagctg tgtaagtcca gtcgtggatc 2401 acttaatgaa ggagcatttt ctgtctttgg cagtttcata attatgcgga ataccattga 2461 gtataattac acaaacctag atggtataga ctactataca ctgaggctat attgtgtagc 2521 ctattgatcc tagctttaaa cccgagcagc atgatactgt tctgaatagt ataaggaaat 2581 agtaacataa tggtaaatat ttgtgtgata ggaattttca gcttgattat aatttttttt 2641 ttttgagaca gggtctcact cactggagtg cagtggtgcg atcttagctc ccctgcaacc 2701 tccgcctctt gggctcgagc aatcctcctg ctgtagtgca ccacgacact cggctaattc 2761 ttttttaaga tttttctgca gacaaggtct cacttactgc ccaagctggt ctcaaactcc 2821 tgggcttaag tgatcctccc acctcggcct cccaaagcgt taggattaca ggcgtgagtc 2881 actctgcctg gccttgatta taatcttatg ggaccactgt ggtctgtagt tgacagaaat 2941 gtcgttaatg tggtgcatga ctgttattat tattttctgt cctgcccctg agagccactg 3001 tcacttctct gctgtattgg tttttgttta ctcatctgtt ttggccttga aatggcctag 3061 acatttttct tcccgaagta tgacactcgg gtgcttatta acttagtcaa gacacaacat 3121 ctcccttccc agaaagtgag gcgggagtga ggacttgggg acttaagaac taccaaagtt 3181 cagagtccaa aggaaacatt agaaattggg taatccaccc ccataacacg cacattttac WO 00/09525 PCT/US99/17712 EPI-109 1077 3241 agatgagaag actgagctca gagcatagaa atagcttgcc caggccatga ctaagtcagg 3301 ataaggagct ggagcttgtt tcctcactca gtggtcctga ctttgcacca ctctgcattt 3361 gcctagcctg ccttcctcta actgtgctct ccctacttcc aggcctcacc tgcagatgcc 3421 ccccagcctg ggccagatga acctgccctt tgaccagcct cacccccagg tgaatgacaa 3481 aagcccctcc tgacccatgt gcctcttctt tcctgggcct tgcccgctct ccttatttcc 3541 attgctggtt cctggcaggg cctgctgccg tgccagcctc aggagcatgc tgtgtccagc 3601 cctgaccccc tgctctgctc agatgtgacc atggtggaag acagctgcct gagccagcca 3661 gtgacagcgt ttcctcaggg cacttggtga gtggcagctt gggagtggag gctgggtggc 3721 atctagggga gtgggcgcca tgcctactcc actgcttctc ccatctcctt gcaggattgg 3781 tgaagacata ttccctcctc tgctgcctcc cactgaacag gacctcacta agcttctcct 3841 ggaggggcaa ggggagtcgg ggggagggtc cttgggggca cagcccctcc tgcagccctc 3901 ccactatggg caatctggga tctcaatgtc ccacatggac ctaagggcca accccagttg 3961 gtgatcccag ctggagggag aacccaaaga gacagctctt ctactacccc cacagacctg 4021 ctctggacac ttgctcatgc cctgccaagc agcagatggg gagggtgccc tcctatcccc 4081 acctactcct gggtcaggag gaaaagacta acaggagaat gcacagtggg tggagccaat 4141 ccactccttc ctttctatca ttcccctgcc cacctccttc cagcactgac tggaagggaa 4201 gttcaggctc tgagacacgc cccaacatgc ctgcacctgc agcgcgcaca cgcacgcaca 4261 cacacataca gagctctctg agggtgatgg ggctgagcag gaggggggct gggtaagagc 4321 acaggttagg gcatggaagg cttctccgcc cattctgacc cagggcctag gacggatagg 4381 caggaacata cagacacatt tacactagag gccagggata gagqatattg ggtctcagcc 4441 ctaggggaat gggaagcagc tgaagggacc ctgggtggga gcataggagg agtctggaca 4501 tgtggttact agtacaggtt ttgccctgat taaaaaatct cccaaagccc caaattcctg 4561 ttagccaggt ggaggcttct gatacgtgta tgagactatg caaaagtaca agggctgaga 4621 ttcttcgtgt atagctgtgt gaacgtgtat gtacctagga tatgttaaat atatagctgg 4681 caccttagtt gcatgaccac atagaacatg tgtctatctg cttttgccta cgtgacaaca 4741 caaatttggg agggtgagac actgcacaga agacagcagc aagtgtgctg gcctctctga 4801 catatgctaa cccccaaata ctctgaattt ggagtctgac tgtgcccaag tgggtccaag 4861 tggctgtgac atctacgtat ggctccacac ctccaatgct gcctgggagc cagggtgaga 4921 gtctgggtcc aggcctggcc atgtggccct ccagtgtatg agagggccct gcctgctgca 4981 tcttttctgt tgccccatcc accgccagct tcccttcact cccctatccc attctccctc 5041 tcaaggcagg ggtcatagat cctaagccat aaaataaatt ttattccaaa ataacaaaat 5101 aaataatcta ctgtacacaa tctgaaaaga aagacgctct aactgctcag ataggtgctg 5161 cggtccagcc cccagctgga ggagaccctg agtccaaccc aggcctcccg agggggccag 5221 tgaagggatc ccacacccac cgcccctatg tagggcaggg aagaaattgc aaaggacttg 5281 ggggatagat gggaatggga gggcaaactg cagcacttgt taaattaatt aaagaaacaa 5341 accagaaca caaaaacggg gaaggagaag ggagaaggag caggtccagt gttccaggcc 5401 ccaattctgg gggcaaatgt gcca (2) INFORMATION FOR SEQ ID NO:2811: (1) SEQUENCE CHARACTERISTICS: (A) LENGTH: _base pairs (H) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2811 1 gcagcaccta tctgagcagt tagagcgct ttcttttcag attgtgtaca gtagattatt 61 tattttgtta ttttggaata aaatttattt tatggcttag gatctatgac ccctgccttg 121 agagggagaa tgggataggg gagtgaaggg aagctggcgg tggatggggc aacagaaaag 181 atgcagcagg cagggccctc tcatacactg gagggccaca tggccaggcc tggacccaga 241 ctctcaccct ggctcccagg cagcattgga ggtgtggagc catacgtaga tgtcacagcc 301 acttggaccc acttgggcac agtcagactc caaattcaga gtatttgggg gttagcatat 361 gtcagagagg ccagcacact tgctgctgtc ttctgtgcag tgtctcaccc tcccaaattt 421 gtgttgtcac gtaggcaaaa gcagatagac acatgttcta tgtggtcatg caactaaggt 481 gccagctata catttaacat atcctaggta catacacgtt cacacagcta tacacgaaga 541 atctcagccc ttgtactttt gcatagtctc atacacgtat cagaagcctc cacctggcta 601 acaggaattt ggggctttgg gagatttttt aatcagggca aaacctgtac tagtaaccac 661 atgtccagac ccctcctatg ctcccaccca gggtcccttg agctgcttcc cattccccta 721 gggctgagac ccaatatcct ctatccctgg cctctagtgt aaatgtgtct gtatgttcct 781 gcctatccgt ccaggccct gggtcagaat gggcggagaa gccttccatg ccctaacctg 841 tgctcttacc cagcccccct cctgctcagc cccatcaccc tcagagagct ctgtatgtgt 901 gtgtgcgtgc gtgtgcgcgc tgcaggtgca ggcatgttgg ggtgtgtctc agagcctgaa 961 cttcccttcc agtcagtact ggaaggaggt gggcagggga atgatagaaa ggaaggagtg 1021 gattggctcc acccactgtg cattctcctg ttagtctttt cctcctgacc caggagtagg 1081 tggggatagg agggcaccct ccccatctgc tgcttggcag ggcatgagca agtgtccaga 1141 gcaggtctgt gggggtagta gaagagctgt ctctttgggt tctccctcca gctgggatca 1201 ccaactgggg ttggccctta ggtccacgtg ggacattgag atcccagatt gcccatagtg 1261 ggagggctgc aggaggggct gtgcccccaa ggaccctccc cccgactccc cttgcccctc 1321 caggagaagc tagtgaggt ccgtcagt gggaggcagc agaggaggga atatgtcttc 1381 accaatcctg caaggagatg ggagaagcag tggagtaggc atggcgccca ctcccctaga WO 00/09525 PCTUS99/17712 EPI-109 1078 1441 tgccacccag cctccactcc caagctgcca ctcac (2) INFORMATION FOR SEQ ID NO:2812: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2812 1 tttattttta atttaatcac ttaattttta atttttaaga tggagtctca ctctgttgcc 61 caggctgaag tgcaagggtg taatctcagc tcactgcagc ctctgcctcc cggattccag 121 tgattttcct gcttcagctt cccaggtagc tgggattgca ggcacatgcc actgtgccca 181 gataattttt tgtatttttt agtagagacg gggcttcacc atgttggcca ggctggtctt 241 gaactcctaa cctcagatga tccgcacacc tcggcctccc aaagtgctag gattacaggc 301 atgagcctct gcgcctggcc tttacttcag tttcaaagag tgaaggtcaa gacactgttt 361 ttttttatgt tttgttttta attttgtttt aaattttttt tgtagagatg ggatcttgct 421 atgttgccca ggctggtctc gaactcctgg cctccagcaa tcctcctgcc tcagcctccc 481 agagtattgg gattacaggt gtgagccatt gtgcttgatc aagatgctgt tatgggctga 541 gttgtgttcc tcaaaaattc tcttgaagtc ctaatctcaa gtacttcagg acgtgacctt 601 attttgaagg acccccttat agggtcttta cagaggtaat taagttaaaa tgaggccatt 661 aggatggggc ctaatgcaat atgactggta tccttgaaaa aaggggaaac ttggagactg 721 acttgcatac aaagagaaca gtgtgtgaac gtgaaaatgg ccaaggaggg aggcctggaa 781 tagagccttc cttcacatcc ctgagaagga atcaatcaat cctgctcagg ttaaccttga 841 tcttggactt ctagcctcca gcatcttgag agatttctgt tgtttaagtc atgcaatatg 901 tagtactttg ttacagcagc cctagcaaac tgatacactc accaaatcga ttttgtgact 961 cactattggg ttgtaaccag cagtacatag acataaagtt attttttcct tacgctttat 1021 cttgtgcaat cgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgacgg 1081 agtcttgttc tgtcaccagg ctggagtgca gtggcttgat ctcggctcac tataatcaca 1141 gccttccaga ttcaagtgat ttccctgcct cagcctcctg agtagctggg actacaggcg 1201 cgcaccacca cgcccgacta attttttgta tttttagtag agacggggtt tcaccatgtt 1261 ggccaggatg gtctcaatct cctgaccttg tgatctgcct gcctcagcct cccaaagtgc 1321 tgggattaca ggcgtgagcc tctcttgtgc aatctttacc accactcaat gggatgtcaa 1381 ggtccagggg agggtgatac agtcaccctc acagtcatgc aggtgcagat gtcattaatg 1441 aaggtctgac agaccctgca attgtacaat ctgaagatga gtatctcctt aaatttcata 1501 ctctaggcac tttaccctag cctagactct gttgaagtag gtataactat tattctcatt 1561 tgagggattg acacctgatt gtgaacctcc taaatggagt catacccaag ccagatttgc 1621 ctctaaattc tgttttttcc ccttacatca cagtgttccc attggtatag tcagttacag 1681 agggagtaat atatactatt tttctaccag tacttgctcc tcgccttcct accccctaaa 1741 aggagccaaa gtcagagatc acatttactc ttttccctcc tcctctccaa gtctttgggg 1801 acttgtagct ctgacaccct tagatggtga aacctggctt cacctactgt ctgtggatgt 1861 ctgcaggcag agtgggcact caggagcaca tacaaagcac gtgtgccgtg aacacgtatg 1921 tgcacacacc ttgatcctag catggcttgt tggacaagcc aatggacaga gtccctgcct 1981 gccacctcca cccctgctct cccttctctt ccattcactg tcctgcagac acagcaaaca 2041 catacgcaca tacaccctca atatcctttt ggcagtaaca tgacccccaa atctggggac 2101 ttctatgtag gatggagacc cttctccttt cctcatacct ggtttattat gaaccataaa 2161 aatagtgcct gacagttact gtgtgtcagg cattgttcta agccttcaga tgttttactg 2221 cattttattc tcacattatg ggttaagact tatttgctcc attttacaga tgacgagaat 2281 gaatcacaga gtaaattgct cagggttgtg tggttagcag cattagcagg atttgaaccc 2341 aagcagcctg tatccacagt ccagtctttt aactgctata ttttgctgtg ttcaaaccct 2401 ctgctgcctg gctgggtcca cacacgtgca ctcatgcaca gacctgcggg gtagcaaggg 2461 atggaggagg aggagctggt tctggaaatc aattcaggca ccagggggca gcataggcct 2521 agctttggcc cctcagccca gcccctgcta tgggagggag gaggggagta gaaacttcct 2581 cccaccgccc ctcagacacc acctcttcca cacaccgggg ctctcaggtg tccgggagta 2641 aaggcctctc tggatccctt ggtctcctcc agctcctccc ccagcaaaaa ctgcagaacc 2701 ctccactagt tatgttgatg actcagaagt tgagcaagac tgtgtgtgtg tgtgtgtgtg 2761 tgtgtgtgtg tgtgtgtgtg tgtgtgtggt gttgtgattg caatgggctc tgtttgtgag 2821 cctgcctgca cgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtagtcttg tggtcaggga 2881 agttgtgcat gtgtgtgttt gtttcttggc gtgtctcagc gtttacccca gaaacatata 2941 ggaacttggc agataggaac acagcagatt cgtattcaaa cttgcccctt gtgaatctgc 3001 aggcagcagc tccggcttgt gctggttccc accacagtct caggaggggt gccctgtgag 3061 gagagagcaa agaccagctt cagtccaagg gactcctaga gtcttccaga attctgagct 3121 gagggttccc ctcccccact ccctcccgtc agtggtcacg agaccgacct ctaaggcgtt 3181 ccctgccgga agggaggggg acctaggagt tggctggcat cgagctccct ggcggctttt 3241 tagggtcctc cactggaggg agcgcagagt ccagagggat ttacttttcc tgaggccctg 3301 gggagcccag tcccttgtgg gtccaaaccc cagcccttgg cagagtttga gtttgggagc 3361 caggcagtta ggggtggcaa atctctgttt gatattgggt gactttctgg agaaaagctg 3421 atgcttttga gggggacaga gtaagtgggg gtcagcctcc ccccaagcct ggctccaagg 3481 cctggacccc agtcctgatc ccccacgtgt tcccccactc ggcacaggag gcacacatat 3541 tcaccccact tccttcctct tcctcctcca gcccactttc tcttctctgt gtcgtcagag WO 00/09525 PCT/US99/17712 EPI-109 1079 3601 ctccagggag ggacctgggt agaaggagaa gccggaaaca gcgggctggg gcagccactg 3661 cttacactga agagggagga cgggagagga gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt 3721 atgtatgtgt gtgctttatc ttatttttct ttttggtggt ggtgttggaa ggggggaggt 3781 gctagcaggg ccagccttga actcgctgga cagagctaca gacctatggg gcctggaagt 3841 gcccgctgag aaagggagaa gacagcagag gggttgccga ggtgaggggt tgcctccgag 3901 gtgggtgcgg gggcctctat gagtgcatgg gggtggattc gtggggggag ctctcgggat 3961 cctcccctgg ctgggtggat ggtccccaan gagatggttt cagctantgt tggtggctgg 4021 tggcactggg ttttancagt ttcgaactcc tggaggaact gggagggtcc aggcctcant 4081 actcccctcc cccatgggtc acgttttcac agcctcaccc ctgcaccccc aagggcccat 4141 ggaaagtcag ggaaaggagq tgaaqgagtg cccctctgcc ctgagtcggg ggaagtggcc 4201 gcccctccct ggaaggttga tcgcagaggg cagtggatcc ttgttaaacc cctatcctgc 4261 cctccactaa aggttcctgt tcaagggtgt ggctggggcg tgagcaagcc ccagatgtag 4321 acctcatggt ggcccagacg agggggaatt tccccctcaa aactgctcca cgcttggctc 4381 gtgtagacgc tgagatttcc cagcggcggc gccgaattaa ccctcctcgt gctgaactgg 4441 ctccacctcc ccgccttgcc cccaccgcca cattcacgca ttgggcaact cagagaagat 4501 gttttaactt tcgatcctgt ggtccacaat gagaggactc gggcagatag gggttgagat 4561 aagcgagttt aggccaccaa gcgggcggac gaggatccca gaccttgcgc ttcccttctg 4621 agtttgggag gtaacactgg ccccgcccct cacgccgtgg ctcctccctc ccttcccctt 4681 caaggggctg aagacaaaag gtgcccctgt cctggtcaag ccaatcgacc cagccttgtt 4741 atgggttggg gtggggaaaa atgagtcctc ctgatggctg gggaagaaga ggggttggat 4801 atttctagcc agggccatgc caggaggctg gtcactctgc aaggggatgc agaggaaagc 4861 ggagcccact cactccagag gacctttctc ttcttgggct agagaaaggc ctattggagg 4921 aacctgagca ggaggggtaa ggattctgcc ttgaggagaa aagagctggg gtaagtgggc 4981 actggaggaa aaaggggcat gaaggtcttg gagcagaaac gtccagagaa gggacctctc 5041 cattttccat ccctctgaga ggcctgggag aggtgagagg ctgaacgtgc aacaggagga 5101 cttggggtta ctgggtttgg ggagacctgg ggagttgtca tcccatcctc tccctcatct 5161 ctgggagagg gatattatga gaaacgtgaa ctgagaggcc cctgggaaac cactggttac 5221 ccagtcctcc ctgaacctgg aaatggggat gcaaccccct cttctacttc cctgtcccct 5281 cctctccttt ctacctgttt tcgtctctca tctttgcctt ctagccctcc agcttcctct 5341 ctcttctagg ctctttcctc ctagcttact aaacccgcct tttttccagt ctcttccatc 5401 ctcttcctta gttctctcta ctttcctttt ccacctctcc tccttcaagt ctcctcccac 5461 cttcccccac ttcttaggat gatcagattt gcccctggaa gggatcctaa caacacagtg 5521 cgatggttaa tccccactca gattcaaagc ctgctttcca aactcactta ctgagtggcc 5581 ttgggcagag tagagaaact ccttaagcct cagtttcttc atctataaaa tgggatatta 5641 tatattttaa aaagtgtcgt gaggcctgaa ggagataata cactgagtgt aatgcctcat 5701 acacagtaag tgcttaacaa atagtagctg ttattactct cccatcctct tcatcatcta 5761 gccttgtggt tttcattttt attttatttc atttatttat ttatttattt tgagcagagt 5821 ctctctctgt cgcccaggct ggagtgcagt ggctcgatct ctgctcactg caagctccgc 5881 cccccaggtt cacgccattc tgtcacctca gcctccccag tagctgggag tacaggcgct 5941 cgccaccacg ccctgctaat tttgtttttg tatttttagt agagatgggg tttcactgtg 6001 ttagccagga tggtcttgat ctcctgacct cgtgatctgc ccgcctcggc ctcccaaagc 6061 gctgggatta caggcatgag ccactgcgcc tggccgagcc ttgtggtttt caaattatct 6121 catggagtcc tagaattttg agaggtttgt ctagggatgc ctttggcgtc aggaggtggg 6181 gagagggaag tagaagcagt cgagtttcag gctttccatg cttgctttca acagggcatc 6241 ttcggtttcg taccttttat gtaattgaga ttccacagat taaaagctga cattgcctac 6301 cgctttaaaa agtttggaaa gttttccact catctaacac tcatatttta tagatgagaa 6361 gatcgaagcc cacaaaggga aggctctttg cccacagaac cagagccagg tctagagctg 6421 caactaaatc ctctgccact ctaagagagc tctcgctcta ctgccctgtc tccctttgcc 6481 tccccatccc tctggctaca gctcagctct tcccacccct gtgtctatca ctgaaggagt 6541 tacccccatc tcaggcattg actcaggatg cccctggttt aaggtggtct ggccatgagt 6601 ggtggtgggg acggtcccta ggagggctat ctatgggagg tcccctggct gccccaggag 6661 ataggccaag tttctttggg cacccctcag agtggcctta tttttttcct ccaggcaacc 6721 tccaagtccc agatcatgtc tctgtggggt ctggtctcca agatgccccc agaaaaagtg 6781 cagcggctct atgtcgactt tccccaacac ctgcggcatc ttctgggtga ctggctggag 6841 agccagccct ggtgagtcct ggctgctccc tgctggtccc ccaagtcttc cctaactcat 6901 cttccttctc cttagatttt tctcccctca cccatggatt cagaacttga gacctgttat 6961 tccatgtgta gtgacctaga tttagcaggg agtctgtgcc ccatcaagac caggctatga 7021 atgttgacag atggagaccc ccatctctta ggaggctgag ccgaagagga ggggggtttg 7081 ggctgggaca aaggcacttc tcataacagc tagaagactg ggaaacaagg cgcatgggtg 7141 aaagctacag agggcctaga tggagaataa ggagcgagaa aggaatgctg acttttggct 7201 gtggggtaaa ggtcaggaaa ctgaagaagc ctggcctgaa gtacctctcc tgatcttcct 7261 gcaagggagt tcctggtcgg ctccgacgcc ttctgctgca acttggctag tgccctactt 7321 tcagacactg tccagcacct tcaggcctcg gtgggagagc agggggaggg gagcaccatc 7381 ttgcaacaca tcagcaccct tgaggtgggg caggagggga ggggacaagg ctgggtgggg 7441 ctgaggttga actgggttga gcattgggcc ctggaagaaa attggttgga tgctggaagc 7501 aaattggtgt tcctgtggtt aactgctagc tagcaggcaa attagatttt aaaagcatgc 7561 aaatgcacaa aaacttctgg agtctacagt ttgcttcct tatagtatat gtgtgaatgc 7621 aggcctgggg attggaggga ttgaaggaca tgggtaagag caaagctcac tgtttaccac WO 00/09525 PCTIUS99/17712 EPI-109 1080 7681 cctcatttct gtagagcata tatcagaggg accccctgaa gctggtggcc actttcagac 7741 aaatacttca aggagagaaa aaagctgtta tggaacaggt attgtgatat tccacctccc 7801 accccaactc aatcccctga gactttggcc tgagccatga caaactagaa agaatttgat 7861 cctcagaaaa ggctcagtgt tctaggccca ggaatgacca aaggaggttc ctagggtcag 7921 agtgaacccc aagtcaagct cagggaatct ttctatgagg gactgaaggt aagaggccgg 7981 ggagaacaga gcaagggata aggagctgat tctgctagga gcaaggtctt atctccacga 8041 tattccaaaa ggtcaggaag aactgccaaa ggggagaggg gaacaagaaa acgctatatg 8101 cagagcagag agtggaggcc aggtatagag ggatgagcag agtgtttgag ttcttggcat 8161 ctgtccttcc tgtgtagttc cgccacttgc caatgccttt ccactggaag caggaagaac 8221 tcaagtttaa gacaggcttg cggaggctgc agcaccgagt aggggagatc caccttctcc 8281 gacaagccct gcagaagggg gctgaggctg gccaaggtgg gggccagggt ggttctgggg 8341 agtgtgtaag agtggttgcc tcttggatct caaccttatc tgaacctcta atctgtctgc 8401 acccttgatt tctgccccca accctcagtg tctctgcaca gcttgataga aactcctgct 8461 aatgggactg ggccaagtga ggtgagtaat gggctgacag gtggagacct tggtcaaagt 8521 gcagctggag qgatggaagc tagacctcaq aaagacacag gctgaagtag ggcaagggaa 8581 tgccagagga gtgagaaaaa gaccgtatcc caggagctgg gtgtggaggc agcgtgaggc 8641 cctggctcag gcccctctct gcccataggc cctggccatg ctactgcagg agaccactgg 8701 agagctagag gcagccaaag ccctagtgct gaagaggatc cagatttgga aacggcagca 8761 gcagctggca gggaatggcg caccgtttga ggagagcctg gccccactcc aggagaggtt 8821 gggctagggc tgatggggaa gagggggcaa gctgggggtg ggcagctgac cctgctgaag 8881 gccctacagg tgagagaaag aagccaggcg ggagggcctt ggcagtggac caagatgcat 8941 aaaagccagt tccagcgggg ctgtgcacac tgtcgttcag gtcgcatcct gtacaagtgg 9001 gcctagtgga ggggcacaag cggggactca tccaacccag gcttctctcc tcaagcccca 9061 tgcctagagg aataggaggg cttttccatt tggtttattg ggtgggaaca cttcccaatt 9121 tgccacaaag cactgtaagt ggtggcagtt gttcttgggt gcaagaaccg tcggggagag 9181 gcagctgggt ttccacaggg ggtgtaggca actgataatg aacctcccac ccacacccta 9241 ggccaacaga tcacagaacc ccttcagccc aggtgccttg cagccacacc cactacccac 9301 cccacttctc cacacatgat agcctttctc cctgggtata ggggaagggg gtctgggccg 9361 gagcaagcag ccttaatcct gtgccccctg accactgtcc tggccccagg tgtgaaagcc 9421 tggtggacat ttattcccag ctacagcagg aggtaggggc ggctggtggg gagcttgagc 9481 ccaagacccg ggcatcgctg actggccggc tggatgaagt cctgagaacc ctcgtcacca 9541 ggtattcccc gggagctccc agtctggcct agaacagacc tcgggaagaa aagaaggggg 9601 ctagagctgt ggggagggca ccagcaggga cctagccccc aactcccctt gtgtcctcct 9661 cactcccagt tgcttcctgg tggagaagca gcccccccag gtactgaaga ctcagaccaa 9721 gttccaggct ggagttcgat tcctgttggg cttgaggttc ctgggggccc cagccaagcc 9781 tccgctggtc agggccgaca tggtgacaga gaagcaggcg cgggagctga gtgtgcctca 9841 gggtcctggg gctggagcgt aagctgggat tggacctggg gttggagaag ggctgttagg 9901 gtgatggagg cagcctggag ggctggcact gaaaagagca agggatgggg agggagggcc 9961 atgggatgtg gagaccctga atggtcaagg cagaggaaag ggagggaccc atttagggct 10021 ggaatggggt gggggcatca tgatttggcc aagatgggga ctcctccctt aagaacccaa 10081 acagagacat ggagatttag ggctggtgac agtgggtagt ctacactcac ccatgcactc 10141 gccacacctg acgacagtga gatgagctcg ttcacactct gacctcccct gggcagagaa 10201 agcactggag aaatcatcaa caacactgtg cccttggaga acagcattcc tgggaactgc 10261 tgctctgccc tgttcaagaa cctggtgagg ggctttgggg tgcagtgagg ggggcaccac 10321 taggagactg tgggactctc cttggagagg atgtcaggaa gcccaggagg agcggtctct 10381 gtcctcatga cctcgccctt gctctccctc accccaccca cagcttctca agaagatcaa 10441 gcggtgtgag cggaagggca ctgagtctgt cacagaggag aagtgcgctg tgctcttctc 10501 tgccagcttc acacttggcc ccggcaaact ccccatccag ctccaggtga accgtggccc 10561 agccctgccc caatctggga ccccgagtcc tcctccaatg ccacgcacaa gggccctgga 10621 ccctcacctc ttgtgactgc cccatacccc atgtgtctgg gattcatgca cactggggcc 10681 cgggtgagtg ggggtgagca agagcatgga gtgcacaggg cagggaatgg tagtggatag 10741 cagcaaacac ttcggaagca cttcctatag accaggggca ctctattaaa tgatacatac 10801 tgcacatgcg tgccagcaca cacacgtctg gttttcacaa taacattatg aggtaggcag 10861 tattatcagc ctcattttat agcatgagga cattgagaca gagagtttaa gtagtttgtc 10921 ccagtcaccc agctaagtgt tggagctggt atctgaaacc tggaagtctg gttccatagc 10981 gattatagta accacttctc tacggtgagg ccctgattga gcttcaaaac gcatttaata 11041 acatgg ggaaagaaag aaagaaaaga aaccctgtcc tcaccctact tcaggccctg tctctgcccc 61 tggtggtcat cgtccatggc aaccaagaca acaatgccaa agccactatc ctgtgggaca 121atgccttctc tgagatggtg aggaaagtcc ttggtagttg gagggaacag ggtgcagggt 181 gggttctaac atgggcagtg gtgcaggcct gctgatgggg tggtgggcat gtcggatggg 241 tgtgacctta acacttcttc atgggcctgc tttcgtgctt ctgacctctt ttcaccccag 301 tcttaacaac tatcaggcca cagcactgta acctagaaaa aacagcatgt ttgtgagcga 361 tatcaggggc tgtggagggg taggccacag gcatgtggga cggatgaagg ccggcccgag 421 gaataacaag acggtagcct gcagtgctct cttcttcccc cttctcccca ggaccgcgtg 481 ccctttgtgg tggctgagcg ggtgccctgg gagaagatgt gtgaaactct gaacctgaag 541 ttcatggctg aggtggggac caaccggggg ctgctcccag agcacttcct cttcctggcc 601 cagaagatct tcaatgacaa cagcctcagt atggaggcct tccagcaccg ttctgtgtcc WO 00/09525 PCT/US99/17712 EPI-109 1081 661 tggtcgcagt tcaacaaggt tcagttctcc 1 gcggccgcga gctctaatac gactcactat agggcgtcga ctcgatcata ccactgcact 61 caagcctggg tgacagagca agactctgtc tcaaaaaaaa aaaaaaaaaa aggccaggca 121 tggtggttca tgcctgtaat cccagcactt tgggaggccg agacggatag atcacctgag 181 gtcaggagtt cgagaccagc ctggccaaca tggcaaaacc ccgtctctac taaaaacaaa 241 aaaatagcca ggatggtcgt ttgcgtctgt aatcccagct actcggctga ggcaggaggt 301 gaacccagga ggtaaaggct gcaggggaag atgaaaccat tqcactccag cctgggcaag 361 actctgtatc aaaaaaaaaa aaaaaaaggc taggtgtggt ggctcacacc tgtaatccca 421 gcactttggg aggctgaggc gggcggatca caaggtcaag aaatcgagac catcctgacc 481 aacatggtga aaccccgtct ctactaaaaa tacaaaaatt acctgggcat ggtggcgcat 541 gcctgtattc ccaactactc gggaggctga ggcatgaaaa tcacttgaac ctgggaggca 601 gaggttgcag gcgagccaag attgtgccac tgcactccag cctgccaaca aaaatgagat 661 tctgtc 1 ggttaccttc cctttgggcg tcaacttctg ccacacctcc ttagggagag ggtgtagcat 61 agtagttaag aggggtccag ggccagaatg cctgggttta aatcctagct ctgcctctta 121 ccagctatgt agacctgggc aagtcattcg acgtttttgg acttccattt cttcatctgt 181 aagatggaat tattataatc cctacttcca tagcctggta aagagcaaat aaatatatgg 241 aaaggcttga aatagtggct ggcacgtgta agoattagga ttggtcgttg tcattgatgg 301 agtctcaggt tcggtctgat cctcagcccc tgtgattctg tcgtgagggc actcacagct 361 cactgcctgc cctaaacagg ctccagctct ggccctccct cggctcacac ctttccccct 421 ctccccctag gagatcctgc tgggccgtgg cttcaccttt tggcagtggt ttgatggtgt 481 cctggacctc accaaacgct gtctccggag ctactggtct gaccggtgag tccccaccct 541 gggtagtttg agcagccata caccagtcac ctccatactc actgcccatg ccccatcctc 601 tccttcatcc cggccaggct gatcattggc ttcatcagca aacagtacgt tactagcctt 661 cttctcaatg agcccgacgg aacctttctc ctccgcttca gcgactcaga gattgggggc 721 atcaccattg cccatgtcat ccggggccag gatggtgagg ccaccccagc cagtcctctg 781 tctctgtgcc tgtgccctct ggggtttctt ctgggaatga aatgtcctga ccttcctgat 841 gccgatcctg atcttcagga agttcttcca gcttctcttc ttccttctgt ggtctaaatg 901 ttcaccttct cactgtgagc tctgtgggaa cggagactag tgggtctctc tccctcagga 961 gccccaccct aggtcctctc tcccttgcct tggtggagtg agaacaggtc ttatggtagg 1021 ggttggggaa ggggaagaaa tccggacaga gggatctcag ggtctccttc ctaccatagg 1081 ctctccacag atagagaaca tccagccatt ctctgccaaa gacctgtcca ttcgctcact 1141 gggggaccga atccgggatc ttgctcagct caaaaatctc tatcccaaga agcccaagga 1201 tgaggctttc cggagccact acaagcgtga gctggaactg gcagctctga ttccttcctg 1261 tcacccactt cctgccatgc tccccgctgc catcctctcc ccagcccgtg agttatcctg 1321 aggtcactcc gaatttccat agctgtgctt ttcttacttc ccggatgatc catgcccacc 1381 ttttccacct cccttcctcc ctaacccgag agcaatccat ggcagtcttt tccatctcac 1441 aacagctgaa cagctgaaca gatgggtaag gatggcaggg gttatgtccc agctaccatc 1501 aagatgaccg tggaaaggtg agtgtggtgg tatggacagt gggtaggtca ggggcttagt 1561 gcttatctgc aggaaggagg ggtggcatca acccttggtc agtcacatgt acctccttcc 1621 ctcctccagg gaccaaccac ttcctacccc agagctccag atgcctacca tggtgccttc 1681 ttatgacctt ggaatggccc ctgattcctc catgagcatg cagcttggcc cagatatggt 1741 gtaaggagct ggaaagacag gaatgggagt ggtctgtgca gatgggctaa tcttagcatg 1801 ggcagctggg agagctggca ctgggggctg aacagggaat cttcctttcc atgagaggga 1861 cacctgttca aaagcagggt gtggtggtgt ccaggagaag ggctggcatc agggggtctg 1921 ttttctttcc ccaggcccca ggtgtaccca ccacactctc actccatccc cccgtatcaa 1981 ggcctctccc cagaagaatc agtcaacgtg ttgtcagcct tccaggagta agtgaaaaac 2041 ctcatgggga taccatccca ctctaagggg gtgggcattt gaattgttag aagaggctct 2101 tctgtgagaa aggagcagca aatgctaaca gcctgtcttc ttctcttctg tccactctaa 2161 tgagggggta gtagttaaga tctggactgc ctaggtttga attctagctc caccacttac 2221 tggtttgggg caaattactt agcctttggt gccttatctg cacaatgggg gataataatg 2281 ctaataataa taacctacct cactgcatta ttgtggagat taaatgagtt cataacactt 2341 aaaaagctcg agcatagtgc atggctcata gcaaaagctg tgtaagtcca gtcgtggatc 2401 acttaatgaa ggagcatttt ctgtctttgg cagtttcata attatgcgga ataccattga 2461 gtataattac acaaacctag atggtataga ctactataca ctgaggctat attgtgtagc 2521 ctattgatcc tagctttaaa cccgagcagc atgatactgt tctgaatagt ataaggaaat 2581 agtaacataa tggtaaatat ttgtgtgata ggaattttca gcttgattat aatttttttt 2641 ttttgagaca gggtctcact cactggagtg cagtggtgcg atcttagctc ccctgcaacc 2701 tccgcctctt gggctcgagc aatcctcctg ctgtagtgca ccacgacact cggctaattc 2761 ttttttaaga tttttctgca gacaaggtct cacttactgc ccaagctggt ctcaaactcc 2821 tgggcttaag tgatcctccc acctcggcct cccaaagcgt taggattaca ggcgtgagtc 2881 actctgcctg gccttgatta taatcttatg ggaccactgt ggtctgtagt tgacagaaat 2941 gtcgttaatg tggtgcatga ctgttattat tattttctgt cctgcccctg agagccactg 3001 tcacttctct gctgtattgg tttttgttta ctcatctgtt ttggccttga aatggcctag 3061 acatttttct tcccgaagta tgacactcgg gtgcttatta acttagtcaa gacacaacat 3121 ctcccttccc agaaagtgag gcgggagtga ggacttgggg acttaagaac taccaaagtt 3181 cagagtccaa aggaaacatt agaaattggg taatccaccc ccataacacg cacattttac 3241 agatgagaag actgagctca gagcatagaa atagcttgcc caggccatga ctaagtcagg WO 00/09525 PCT/US99/17712 EPI-109 1082 3301 ataaggagct ggagcttgtt tcctcactca gtggtcctga ctttgcacca ctctgcattt 3361 gcctagcctg ccttcctcta actgtgctct ccctacttcc aggcctcacc tgcagatgcc 3421 ccccagcctg ggccagatga acctgccctt tgaccagcct cacccccagg tgaatgacaa 3481 aagcccctcc tgacccatgt gcctcttctt tcctgggcct tgcccgctct ccttatttcc 3541 attgctggtt cctggcaggg cctgctgccg tgccagcctc aggagcatgc tgtgtccagc 3601 cctgaccccc tgctctgctc agatgtgacc atggtggaag acagctgcct gagccagcca 3661 gtgacagcgt ttcctcaggg cacttggtga gtggcagctt gggagtggag gctgggtggc 3721 atctagggga gtgggcgcca tgcctactcc actgcttctc ccatctcctt gcaggattgg 3781 tgaagacata ttccctcctc tgctgcctcc cactgaacag gacctcacta agcttctcct 3841 ggaggggcaa ggggagtcgg ggggagggtc cttgggggca cagcccctcc tgcagccctc 3901 ccactatggg caatctggga tctcaatgtc ccacatggac ctaagggcca accccaqttg 3961 gtgatcccag ctggagggag aacccaaaga gacagctctt ctactacccc cacagacctg 4021 ctctggacac ttgctcatgc cctgccaagc agcagatggg gagggtgccc tcctatcccc 4081 acctactcct gggtcaggag gaaaagacta acaggagaat gcacagtggg tggagccaat 4141 ccactccttc ctttctatca ttcccctgcc cacctccttc cagcactgac tggaagggaa 4201 gttcaggctc tgagacacgc cccaacatgc ctgcacctgc agcgcgcaca cgcacgcaca 4261 cacacataca gagctctctg agggtgatgg ggctgagcag gaggggggct gggtaagagc 4321 acaggttagg gcatggaagg cttctccgcc cattctgacc cagggcctag gacggatagg 4381 caggaacata cagacacatt tacactagag gccagggata gaggatattg ggtctcagcc 4441 ctaggggaat gggaagcagc tgaagggacc ctgggtggga gcataggagg agtctggaca 4501 tgtggttact agtacaggtt ttgccctgat taaaaaatct cccaaagccc caaattcctg 4561 ttagccaggt ggaggcttct gatacgtgta tgagactatg caaaagtaca agggctgaga 4621 ttcttcgtgt atagctgtgt gaacgtgtat gtacctagga tatgttaaat atatagctgg 4681 caccttagtt gcatgaccac atagaacatg tgtctatctg cttttgccta cgtgacaaca 4741 caaatttggg agggtgagac actgcacaga agacagcagc aagtgtgctg gcctctctga 4801 catatgctaa cccccaaata ctctgaattt ggagtctgac tgtgcccaag tgggtccaag 4861 tggctgtgac atctacgtat ggctccacac ctccaatgct gcctgggagc cagggtgaga 4921 gtctgggtcc aggcctggcc atgtggccct ccagtgtatg agagggccct gcctgctgca 4981 tcttttctgt tgccccatcc accgccagct tcccttcact cccctatccc attctccctc 5041 tcaaggcagg ggtcatagat cctaagccat aaaataaatt ttattccaaa ataacaaaat 5101 aaataatcta ctgtacacaa tctgaaaaga aagacgctct aactgctcag ataggtgctg 5161 cggtccagcc cccagctgga ggagaccctg agtccaaccc aggcctcccg agggggccag 5221 tgaagggatc ccacacccac cgcccctatg tagggcaggg aagaaattgc aaaggacttg 5281 ggggatagat gggaatggga gggcaaactg cagcacttgt taaattaatt aaagaaacaa 5341 accagaagca caaaaacggg gaaggagaag ggagaaggag caggtccagt gttccaggcc 5401 ccaattctgg gggcaaatgt gcca 1 gcagcaccta tctgagcagt tagagcgtct ttcttttcag attgtgtaca gtagattatt 61 tattttgtta ttttggaata aaatttattt tatggcttag gatctatgac ccctgccttg 121 agagggagaa tgggataggg gagtgaaggg aagctggcgg tggatggggc aacagaaaag 181 atgcagcagg cagggccctc tcatacactg gagggccaca tggccaggcc tggacccaga 241 ctctcaccct ggctcccagg cagcattgga ggtgtggagc catacgtaga tgtcacagcc 301 acttggaccc acttgggcac agtcagactc caaattcaga gtatttgggg gttagcatat 361 gtcagagagg ccagcacact tgctgctgtc ttctgtgcag tgtctcaccc tcccaaattt 421 gtgttgtcac gtaggcaaaa gcagatagac acatgttcta tgtggtcatg caactaaggt 481 gccagctata catttaacat atcctaggta catacacgtt cacacagcta tacacgaaga 541 atctcagccc ttgtactttt gcatagtctc atacacgtat cagaagcctc cacctggcta 601 acaggaattt ggggctttgg gagatttttt aatcagggca aaacctgtac tagtaaccac 661 atgtccagac ccctcctatg ctcccaccca gggtcccttg agctgcttcc cattccccta 721 gggctgagac ccaatatcct ctatccctgg cctctagtgt aaatgtgtct gtatgttcct 781 gcctatccgt cctaggccct gggtcagaat gggcggagaa gccttccatg ccctaacctg 841 tgctcttacc cagcccccct cctgctcagc cccatcaccc tcagagagct ctgtatgtgt 901 gtgtgcgtgc gtgtgcgcgc tgcaggtgca ggcatgttgg ggtgtgtctc agagcctgaa 961 cttcccttcc agtcagtact ggaaggaggt gggcagggga atgatagaaa ggaaggagtg 1021 gattggctcc acccactgtg cattctcctg ttagtctttt cctcctgacc caggagtagg 1081 tggggatagg agggcaccct ccccatctgc tgcttggcag ggcatgagca agtgtccaga 1141 gcaggtctgt gggggtagta gaagagctgt ctctttgggt tctccctcca gctgggatca 1201 ccaactgggg ttggccctta qgtccatgtg ggacattgag atcccagatt gcccatagtg 1261 ggagggctgc aggaggggct gtgcccccaa ggaccctccc cccgactccc cttgcccctc 1321 caggagaagc ttagtgaggt cctgttcagt gggaggcagc agaggaggga atatgtcttc 1381 accaatcctg caaggagatg ggagaagcag tggagtaggc atggcgccca ctcccctaga 1441 tgccacccag cctccactcc caagctgcca ctcac (2) INFORMATION FOR SEQ ID NO:2813: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2813 WO 00/09525 PCT/US99/17712 EPI-109 1083 1 cgccatcccg cgctctgcgg actgggaggc ccgggccagg acgcgagtct gcgcagccga 61 ggttccccag cgccccctgc agccgcgcgt aggcagagac ggagcccggc cctgcgcctc 121 cgcaccacgc ccgggacccc acccagcggc ccgtacccgg agaagcagcg cgagcacccg 181 aagctcccgg ctcggcggca gaaaccggga gtggggccgg gcgagtgcgc ggcatcccag 241 gccggcccga acgtccgccc gcggtgggcc gacttcccct cctcttccct ctctccttcc 301 tttagcccgc tggcgccgga cacgctgcgc ctcatctctt ggggcgttct tccccgttgg 361 ccaaccgtcg catcccgtgc aactttgggg tagtggccgc ttagtgttga atgttcccca 421 ccgagagcgc atggcttggg aagcgaggcg cgaacccggg ccccgaagcc gccgtccggg 481 agacggtgat gctgttgctg tgcctggggg tcccgaccgg ccgcccctac aacgtggaca 541 ctgagagcgc gctgctttac cagggccccc acaacacgct gttcggctac tcggtcgtgc 601 tgcacagcca cggggcgaac cgatggctcc tagtgggtgc gcccactgcc aactggctcg 661 ccaacgcttc agtgatcaat cccggggcga tttacagatg caggatcgga aagaatcccg 721 gccagacgtg cgaacagctc cagctgggta gccctaatgg agaaccttgt ggaaagactt 781 gtttggaaga gagagacaat cagtggttgg gggtcacact ttccagacag ccaggagaaa 841 atggatccat cgtgacttgt gggcatagat ggaaaaatat attttacata aagaatgaaa 901 ataagctccc cactggtggt tgctatggag tgccccctga tttacgaaca gaactgagta 961 aaagaatagc tccgtgttat caagattatg tgaaaaaatt tggagaaaat tttgcatcat 1021 gtcaagctgg aatatccagt ttttacacaa aggatttaat tgtgatgggg gccccaggat 1081 catcttactg gactggctct ctttttgtct acaatataac tacaaataaa tacaaggctt 1141 ttttagacaa acaaaatcaa gtaaaatttg gaagttattt aggatattca gtcggagctg 1201 gtcattttcg gagccagcat actaccgaag tagtcggagg agctcctcaa catgagcaga 1261 ttggtaaggc atatatattc agcattgatg aaaaagaact aaatatctta catgaaatga 1321 aaggtaaaaa gcttggatcg tactttggag cttctgtctg tgctgtggac ctcaatgcag 1381 atggcttctc agatctgctc gtgggagcac ccatgcagag caccatcaga gaggaaggaa 1441 gagtgtttgt gtacatcaac tctggctcgg gagcagtaat gaatgcaatg gaaacaaacc 1501 tcgttggaag tgacaaatat gctgcaagat ttggggaatc tatagttaat cttggcgaca 1561 ttgacaatga tggctttgaa gatgttgcta tcggagctcc acaagaagat gacttgcaag 1621 gtgctattta tatttacaat ggccgtgcag atgggatctc gtcaaccttc tcacagagaa 1681 ttgaaggact tcagatcagc aaatcgttaa gtatgtttgg acagtctata tcaggacaaa 1741 ttgatgcaga taataatggc tatgtagatg tagcagttgg tgcttttcgg tctgattctg 1801 ctgtcttgct aaggacaaga cctgtagtaa ttgttgacgc ttctttaagc caccctgagt 1861 cagtaaatag aacgaaattt gactgtgttg aaaatggatg gccttctgtg tgcatagatc 1921 taacactttg tttctcatat aagggcaagg aagttccagg ttacattgtt ttgttttata 1981 acatgagttt ggatgtgaac agaaaggcag agtctccacc aagattctat ttctcttcta 2041 atggaacttc tgacgtgatt acaggaagca tacaggtgtc cagcagagaa gctaactgta 2101 gaacacatca agcatttatg cggaaagatg tgcgggacat cctcacccca attcagattg 2161 aagctgctta ccaccttggt cctcatgtca tcagtaaacg aagtacagag gaattcccac 2221 cacttcagcc aattcttcag cagaagaaag aaaaagacat aatgaaaaaa acaataaact 2281 ttgcaaggtt ttgtgcccat gaaaattgtt ctgctgattt acaggtttct gcaaagattg 2341 ggtttttgaa gccccatgaa aataaaacat atcttgctgt tgggagtatg aagacattga 2401 tgttgaatgt gtccttgttt aatgctggag atgatgcata tgaaacgact ctacatgtca 2461 aactacccgt gggtctttat ttcattaaga ttttagagct ggaagagaag caaataaact 2521 gtgaagtcac agataactct ggcgtggtac aacttgactg cagtattggc tatatatatg 2581 tagatcatct ctcaaggata gatattagct ttctcctgga tgtgagctca ctcagcagag 2641 cggaagagga cctcagtatc acagtgcatg ctacctgtga aaatgaagag gaaatggaca 2701 atctaaagca cagcagagtg actgtagcaa tacctttaaa atatgaggtt aagctgactg 2761 ttcatgggtt tgtaaaccca acttcatttg tgtatggatc aaatgatgaa aatgagcctg 2821 aaacgtgcat ggtggagaaa atgaacttaa ctttccatgt tatcaacact ggcaatagta 2881 tggctcccaa tgttagtgtg gaaataatgg taccaaattc ttttagcccc caaactgata 2941 agctgttcaa cattttggat gtccagacta ctactggaga atgccacttt gaaaattatc 3001 aaagagtgtg tgcattagag cagcaaaaga gtgcaatgca gaccttgaaa ggcatagtcc 3061 agttcttgtc caagactgat aagaggctat tgtactgcat aaaagctgat ccacattgtt 3121 taaatttctt gtgtaatttt gggaaaatgg aaagtggaaa agaagccagt gttcatatcc 3181 aactggaagg ccggccatcc attttagaaa tggatgagac ttcagcactc aagtttgaaa 3241 taagagcaac aggttttcca gagccaaatc caagagtaat tgaactaaac aaggatgaga 3301 atgttgcgca tgttctactg gaaggactac atcatcaaag acccaaacgt tatttcacca 3361 tagtgattat ttcaagtagc ttgctacttg gacttattgt acttctgttg atctcatatg 3421 ttatgtggaa ggctggcttc tttaaaagac aatacaaatc tatcctacaa gaagaaaaca 3481 gaagagacag ttggagttat atcaacagta aaagcaatga tgattaagga cttctttcaa 3541. attgagagaa tggaaaacag cccgccc (2) INFORMATION FOR SEQ ID NO:2814: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: _base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2814 1 gaattccggg ccgcttagtg ttgaatgttc cccaccgaga gcgcatggct tgggaagcga WO 00/09525 PCT/US99/17712 EPI-109 1084 61 ggcgcgaacc cgggccccga agccgccgtc cgggagacgg tgatgctgtt gctgtgcctg 121 ggggtcccga ccggccgccc ctacaacgtg gacactgaga gcgcgctgct ttaccagggc 181 ccccacaaca cgctgttcgg ctactcggtc gtgctgcaca gccacggggc gaaccgatgg 241 ctcctagtgg gtgcgcccac tgccaactgg ctcgccaacg cttcagtgat caatcccggg 301 gcgatttaca gatgcaggat cggaaagaat cccggccaga cgtgcgaaca gctccagctg 361 ggtagcccta atggagaacc ttgtggaaag acttgtttgg aagagagaga caatcagtgg 421 ttgggggtca cactttccag acagccagga gaaaatggat ccatcgtgac ttgtgggcat 481 agatggaaaa atatatttta cataaagaat gaaaataagc tccccactgg tggttgctat 541 ggagtgcccc ctgatttacg aacagaactg agtaaaagaa tagctccgtg ttatcaagat 601 tatgtgaaaa aatttggaga aaattttgca tcatgtcaag ctggaatatc cagtttttac 661 acaaaggatt taattgtgat gggggcccca ggatcatctt actggactgg ctctcttttt 721 gtctacaata taactacaaa taaatacaag gcttttttag acaaacaaaa tcaagtaaaa 781 tttggaagtt atttaggata ttcagtcgga gctggtcatt ttcggagcca gcatactacc 841 gaagtagtcg gaggagctcc tcaacatgag cagattggta aggcatatat attcagcatt 901 gatgaaaaag aactaaatat cttacatgaa atgaaaggta aaaagcttgg atcgtacttt 961 ggagcttctg tctgtgctgt ggacctcaat gcagatggct tctcagatct gctcgtggga 1021 gcacccatgc agagcaccat cagagaggaa ggaagagtgt ttgtgtacat caactctggc 1081 tcgggagcag taatgaatgc aatggaaaca aacctcgttg gaagtgacaa atatgctgca 1141 agatttgggg aatctatagt taatcttggc gacattgaca atgatggctt tgaagatgtt 1201 gctatcggag ctccacaaga agatgacttg caaggtgcta tttatattta caatggccgt 1261 gcagatggga tctcgtcaac cttctcacag agaattgaag gacttcagat cagcaaatcg 1321 ttaagtatgt ttggacagtc tatatoagga caaattgatg cagataataa tggctatgta 1381 gatgtagcag ttggtgcttt tcggtctgat tctgctgtct tgctaaggac aagacctgta 1441 gtaattgttg acgcttcttt aagccaccct gagtcagtaa atagaacgaa atttgactgt 1501 gttgaaaatg gatggccttc tgtgtgcata gatctaacac tttgtttctc atataagggc 1561 aaggaagttc caggttacat tgttttgttt tataacatga gtttggatgt gaacagaaag 1621 gcagagtctc caccaagatt ctatttctct tctaatggaa cttctgacgt gattacagga 1681 agcatacagg tgtccagcag agaagctaac tgtagaacac atcaagcatt tatgcggaaa 1741 gatgtgcggg acatcctcac cccaattcag attgaagctg cttaccacct tggtcctcat 1801 gtcatcagta aacgaagtac agaggaattc ccaccacttc agccaattct tcagcagaag 1861 aaagaaaaag acataatgaa aaaaacaata aactttgcaa ggttttgtgc ccatgaaaat 1921 tgttctgctg atttacaggt ttctgcaaag attgggtttt tgaagcccca tgaaaataaa 1981 acatatcttg ctgttgggag tatgaagaca ttgatgttga atgtgtcctt gtttaatgct 2041 ggagatgatg catatgaaac gactctacat gtcaaactac ccgtgggtct ttatttcatt 2101 aagattttag agctggaaga gaagcaaata aactgtgaag tcacagataa ctctggcgtg 2161 gtacaacttg actgcagtat tggctatata tatgtagatc atctctcaag gatagatatt 2221 agctttctcc tggatgtgag ctcactcagc agagcggaag aggacctcag tatcacagtg 2281 catgctacct gtgaaaatga agaggaaatg gacaatctaa agcacagcag agtgactgta 2341 gcaatacctt taaaatatga ggttaagctg actgttcatg ggtttgtaaa cccaacttca 2401 tttgtgtatg gatcaaatga tgaaaatgag cctgaaacgt gcatggtgga gaaaatgaac 2461 ttaactttcc atgttatcaa cactggcaat agtatggctc ccaatgttag tgtggaaata 2521 atggtaccaa attcttttag cccccaaact gataagctgt tcaacatttt ggatgtccag 2581 actactactg gagaatgcca ctttgaaaat tatcaaagag tgtgtgcatt agagcagcaa 2641 aagagtgcaa tgcagacctt gaaaggcata gtccggttct tgtccaagac tgataagagg 2701 ctattgtact gcataaaagc tgatccacat tgtttaaatt tcttgtgtaa ttttgggaaa 2761 atggaaagtg gaaaagaagc cagtgttcat atccaactgg aaggccggcc atccatttta 2821 gaaatggatg agacttcag c actcaagttt gaaataagag caacaggttt tccagagcca 2881 aatccaagag taattgaact aaacaaggat gagaatgttg cgcatgttct actggaagga 2941 ctacatcatc aaagacccaa acgttatttc accatagtga ttatttcaag tagcttgcta 3001 cttggactta ttgtacttct gttgatctca tatgttatgt ggaaggctgg cttctttaaa 3061 agacaataca aatctatcct acaagaagaa aacagaagag acagttggag ttatatcaac 3121 agtaaaagca atgatgatta aggacttctt tcaaattgag agaatggaaa acagactcag 3181 gttgtagtaa agaaatttaa aagacactgt ttacaagaaa aaatgaattt tgtttggact 3241 tcttttactc atgatcttgt gacatattat gtcttcatgc aaggggaaaa tctcagcaat 3301 gattactctt tgagatagaa gaactgcaaa ggtaataata cagccaaaga taatctctca 3361 gcttttaaat gggtagagaa acactaaagc attcaattta ttcaagaaaa gtaagccctt 3421 gaagatatct tgaaatgaaa gtataactga gttaaattat actggagaag tcttagactt 3481 gaaatactac ttaccatatg tgcttgcctc agtaaaatga accccactgg gtgggcagag 3541 gttcatttca aatacatctt tgatacttgt tcaaaatatg ttctttaaaa atataatttt 3601 ttagagagct gttcccaaat tttctaacga gtggaccatt atcactttaa agccctttat 3661 ttataataca tttcctacgg gctgtgttcc aacaaccatt ttttttcagc agactatgaa 3721 tattatagta ttataggcca aactggcaaa cttcagactg aacatgtaca ctggtttgag 3781 ctcagtgaaa tgacttccgg aatct (2) INFORMATION FOR SEQ ID NO:2815: (1) SEQUENCE CHARACTERISTICS: (A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single WO 00/09525 PCT/US99/17712 EPI-109 1085 (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2815 1 cgccatcccg cgctctgcgg actgggaggc ccgggccagg acgcgagtct gcgcagccga 61 ggttccccag cgccccctgc agccgcgcgt aggcagagac ggagcccggc cctgcgcctc 121 cgcaccacgc ccgggacccc acccagcggc ccgtacccgg agaagcagcg cgagcacccg 181 aagctcccgg ctcggcggca gaaaccggga gtggggccgg gcgagtgcgc ggcatcccag 241 gccggcccga acgtccgccc gcggtgggcc gacttcccct cctcttccct ctctccttcc 301 tttagcccgc tggcgccgga cacgctgcgc ctcatctctt ggggcgttct tccccgttgg 361 ccaaccgtcg catcccgtgc aactttgggg tagtggccgc ttagtgttga atgttcccca 421 ccgagagcgc atggcttggg aagcgaggcg cgaacccggg ccccgaagcc gccgtccggg 481 agacggtgat gctgttgctg tgcctggggg tcccgaccgg ccgcccctac aacgtggaca 541 ctgagagcgc gctgctttac cagggccccc acaacacgct gttcggctac tcggtcgtgc 601 tgcacagcca cggggcgaac cgatggctcc tagtgggtgc gcccactgcc aactggctcg 661 ccaacgcttc agtgatcaat cccggggcga tttacagatg caggatcgga aagaatcccg 721 gccagacgtg cgaacagctc cagctgggta gccctaatgg agaaccttgt ggaaagactt 781 gtttggaaga gagagacaat cagtggttgg gggtcacact ttccagacag ccaggagaaa 841 atggatccat cgtgacttgt gggcatagat ggaaaaatat attttacata aagaatgaaa 901 ataagctccc cactggtggt tgctatggag tgccccctga tttacgaaca gaactgagta 961 aaagaatagc tccgtgttat caagattatg tgaaaaaatt tggagaaaat tttgcatcat 1021 gtcaagctgg aatatccagt ttttacacaa aggatttaat tgtgatgggg gccccaggat 1081 catcttactg gactggctct ctttttgtct acaatataac tacaaataaa tacaaggctt 1141 ttttagacaa acaaaatcaa gtaaaatttg gaagttattt aggatattca gtcggagctg 1201 gtcattttcg gagccagcat actaccgaag tagtcggagg agctcctcaa catgagcaga 1261 ttggtaaggc atatatattc agcattgatg aaaaagaact aaatatctta catgaaatga 1321 aaggtaaaaa gcttggatcg tactttggag cttctgtctg tgctgtggac ctcaatgcag 1381 atggcttctc agatctgctc gtgggagcac ccatgcagag caccatcaga gaggaaggaa 1441 gagtgtttgt gtacatcaac tctggctcgg gagcagtaat gaatgcaatg gaaacaaacc 1501 tcgttggaag tgacaaatat gctgcaagat ttggggaatc tatagttaat cttggcgaca 1561 ttgacaatga tggctttgaa gatgttgcta tcggagctcc acaagaagat gacttgcaag 1621 gtgctattta tatttacaat ggccgtgcag atgggatctc gtcaaccttc tcacagagaa 1681 ttgaaggact tcagatcagc aaatcgttaa gtatgtttgg acagtctata tcaggacaaa 1741 ttgatgcaga taataatggc tatgtagatg tagcagttgg tgcttttcgg tctgattctg 1801 ctgtcttgct aaggacaaga cctgtagtaa ttgttgacgc ttctttaagc caccctgagt 1861 cagtaaatag aacgaaattt gactgtgttg aaaatggatg gccttctgtg tgcatagatc 1921 taacactttg tttctcatat aagggcaagg aagttccagg ttacattgtt ttgttttata 1981 acatgagttt ggatgtgaac agaaaggcag agtctccacc aagattctat ttctcttcta 2041 atggaacttc tgacgtgatt acaggaagca tacaggtgtc cagcagagaa gctaactgta 2101 gaacacatca agcatttatg cggaaagatg tgcgggacat cctcacccca attcagattg 2161 aagctgctta ccaccttggt cctcatgtca tcagtaaacg aagtacagag gaattcccac 2221 cacttcagcc aattcttcag cagaagaaag aaaaagacat aatgaaaaaa acaataaact 2281 ttgcaaggtt ttgtgcccat gaaaattgtt ctgctgattt acaggtttct gcaaagattg 2341 ggtttttgaa gccccatgaa aataaaacat atcttgctgt tgggagtatg aagacattga 2401 tgttgaatgt gtccttgttt aatgctggag atgatgcata tgaaacgact ctacatgtca 2461 aactacccgt gggtctttat ttcattaaga ttttagagct ggaagagaag caaataaact 2521 gtgaagtcac agataactct ggcgtggtac aacttgactg cagtattggc tatatatatg 2581 tagatcatct ctcaaggata gatattagct ttctcctgga tgtgagctca ctcagcagag 2641 cggaagagga cctcagtatc acagtgcatg ctacctgtga aaatgaagag gaaatggaca 2701 atctaaagca cagcagagtg actgtagcaa tacctttaaa atatgaggtt aagctgactg 2761 ttcatgggtt tgtaaaccca acttcatttg tgtatggatc aaatgatgaa aatgagcctg 2821 aaacgtgcat ggtggagaaa atgaacttaa ctttccatgt tatcaacact ggcaatagta 2881 tggctcccaa tgttagtgtg gaaataatgg taccaaattc ttttagcccc caaactgata 2941 agctgttcaa cattttggat gtccagacta ctactggaga atgccacttt gaaaattatc 3001 aaagagtgtg tgcattagag cagcaaaaga gtgcaatgca gaccttgaaa ggcatagtcc 3061 agttcttgtc caagactgat aagaggctat tgtactgcat aaaagctgat Ccacattgtt 3121 taaatttctt gtgtaatttt gggaaaatgg aaagtggaaa agaagccagt gttcatatcc 3181 aactggaagg ccggccatcc attttagaaa tggatgagac ttcagcactc aagtttgaaa 3241 taagagcaac aggttttcca gagccaaatc caagagtaat tgaactaaac aaggatgaga 3301 atgttgcgca tgttctactg gaaggactac atcatcaaag acccaaacgt tatttcacca 3361 tagtgattat ttcaagtagc ttgctacttg gacttattgt acttctgttg atctcatatg 3421 ttatgtggaa ggctggcttc tttaaaagac aatacaaatc tatcctacaa gaagaaaaca 3481 gaagagacag ttggagttat atcaacagta aaagcaatga tgattaagga cttctttcaa 3541 attgagagaa tggaaaacag cccgccc 1 gaattccggg ccgcttagtg ttgaatgttc ccaccgaga gcgcatggct tgggaagcga 61 ggcgcgaacc cgggccccga agccgccgtc cgggagacgg tgatgctgtt gctgtgcctg 121 ggggtcccga ccggccgccc ctacaacgtg gacactgaga gcgcgctgct ttaccagggc 181 ccccacaaca cgctgttcgg ctactcggtc gtgctgcaca gccacggggc gaaccgatgg 241 ctcctagtgg gtgcgcccac tgccaactgg ctcgccaacg cttcagtgat caatcccggg 301 gcgatttaca gatgcaggat cggaaagaat cccggccaga cgtgcgaaca gctccagctg WO 00/09525 PCT/US99/17712 EPI-109 1086 361 ggtagcccta atggagaacc ttgtggaaag acttgtttgg aagagagaga caatcagtgg 421 ttgggggtca cactttccag acagccagga gaaaatggat ccatcgtgac ttgtgggcat 481 agatggaaaa atatatttta cataaagaat gaaaataagc tccccactgg tggttgctat 541 ggagtgcccc ctgatttacg aacagaactg agtaaaagaa tagctccgtg ttatcaagat 601 tatgtgaaaa aatttggaga aaattttgca tcatgtcaag ctggaatatc cagtttttac 661 acaaaggatt taattgtgat gggggcccca ggatcatctt actggactgg ctctcttttt 721 gtctacaata taactacaaa taaatacaag gcttttttag acaaacaaaa tcaagtaaaa 781 tttggaagtt atttaggata ttcagtcgga gctggtcatt ttcggagcca gcatactacc 841 gaagtagtcg gaggagctcc tcaacatgag cagattggta aggcatatat attcagcatt 901 gatgaaaaag aactaaatat cttacatgaa atgaaaggta aaaagcttgg atcgtacttt 961 ggagcttctg tctgtgctgt ggacctcaat gcagatggct tctcagatct gctcgtggga 1021 gcacccatgc agagcaccat cagagaggaa ggaagagtgt ttgtgtacat caactctggc 1081 tcgggagcag taatgaatgc aatggaaaca aacctcgttg gaagtgacaa atatgctgca 1141 agatttgggg aatctatagt taatcttggc gacattgaca atgatggctt tgaagatgtt 1201 gctatcggag ctccacaaga agatgacttg caaggtgcta tttatattta caatggccgt 1261 gcagatggga tctcgtcaac cttctcacag agaattgaag gacttcagat cagcaaatcg 1321 ttaagtatgt ttggacagtc tatatcagga caaattgatg cagataataa tggctatgta 1381 gatgtagcag ttggtgcttt tcggtctgat tctgctgtct tgctaaggac aagacctgta 1441 gtaattgttg acgcttcttt aagccaccct gagtcagtaa atagaacgaa atttgactgt 1501 gttgaaaatg gatggccttc tgtgtgcata gatctaacac tttgtttctc atataagggc 1561 aaggaagttc caggttacat tgttttgttt tataacatga gtttggatgt gaacagaaag 1621 gcagagtctc caccaagatt ctatttctct tctaatggaa cttctgacgt gattacagga 1681 agcatacagg tgtccagcag agaagctaac tgtagaacac atcaagcatt tatgcggaaa 1741 gatgtgcggg acatcctcac cccaattcag attgaagctg cttaccacct tggtcctcat 1801 gtcatcagta aacgaagtac agaggaattc ccaccacttc agccaattct tcagcagaag 1861 aaagaaaaag acataatgaa aaaaacaata aactttgcaa ggttttgtgc ccatgaaaat 1921 tgttctgctg atttacaggt ttctgcaaag attgggtttt tgaagcccca tgaaaataaa 1981 acatatcttg ctgttgggag tatgaagaca ttgatgttga atgtgtcctt gtttaatgct 2041 ggagatgatg catatgaaac gactctacat gtcaaactac ccgtgggtct ttatttcatt 2101 aagattttag agctggaaga gaagcaaata aactgtgaag tcacagataa ctctggcgtg 2161 gtacaacttg actgcagtat tggctatata tatgtagatc atctctcaag gatagatatt 2221 agctttctcc tggatgtgag ctcactcagc agagcggaag aggacctcag tatcacagtg 2281 catgctacct gtgaaaatga agaggaaatg gacaatctaa agcacagcag agtgactgta 2341 gcaatacctt taaaatatga ggttaagctg actgttcatg ggtttgtaaa cccaacttca 2401 tttgtgtatg gatcaaatga tgaaaatgag cctgaaacgt gcatggtgga gaaaatgaac 2461 ttaactttcc atgttatcaa cactggcaat agtatggctc ccaatgttag tgtggaaata 2521 atggtaccaa attcttttag cccccaaact gataagctgt tcaacatttt ggatgtccag 2581 actactactg gagaatgcca ctttgaaaat tatcaaagag tgtgtgcatt agagcagcaa 2641 aagagtgcaa tgcagacctt gaaaggcata gtccggttct tgtccaagac tgataagagg 2701 ctattgtact gcataaaagc tgatccacat tgtttaaatt tcttgtgtaa ttttgggaaa 2761 atggaaagtg gaaaagaagc cagtgttcat atccaactgg aaggccggcc atccatttta 2821 gaaatggatg agacttcagc actcaagttt gaaataagag caacaggttt tccagagcca 2881 aatccaagag taattgaact aaacaaggat gagaatgttg cgcatgttct actggaagga 2941 ctacatcatc aaagacccaa acgttatttc accatagtga ttatttcaag tagcttgcta 3001 cttggactta ttgtacttct gttgatctca tatgttatgt ggaaggctgg cttctttaaa 3061 agacaataca aatctatcct acaagaagaa aacagaagag acagttggag ttatatcaac 3121 agtaaaagca atgatgatta aggacttctt tcaaattgag agaatggaaa acagactcag 3181 gttgtagtaa agaaatttaa aagacactgt ttacaagaaa aaatgaattt tgtttggact 3241 tcttttactc atgatcttgt gacatattat gtcttcatgc aaggggaaaa tctcagcaat 3301 gattactctt tgagatagaa gaactgcaaa ggtaataata cagccaaaga taatctctca 3361 gcttttaaat gggtagagaa acactaaagc attcaattta ttcaagaaaa gtaagccctt 3421 gaagatatct tgaaatgaaa gtataactga gttaaattat actggagaag tcttagactt 3481 gaaatactac ttaccatatg tgcttgcctc agtaaaatga accccactgg gtgggcagag 3541 gttcatttca aatacatctt tgatacttgt tcaaaatatg ttctttaaaa atataatttt 3601 ttagagagct gttcccaaat tttctaacga gtggaccatt atcactttaa agccctttat 3661 ttataataca tttcctacgg gctgtgttcc aacaaccatt ttttttcagc agactatgaa 3721 tattatagta ttataggcca aactggcaaa cttcagactg aacatgtaca ctggtttgag 3781 cttagtgaaa tgacttccgg aatct (2) INFORMATION FOR SEQ ID NO:2816: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: _base pairs (B) TYPE: nucleic acid (C) STRA14DEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2816 (2) INFORMATION FOR SEQ ID NO:2817: WO 00/09525 PCT/US99/17712 EPI-109 1087 (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: _ base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2817 (2) INFORMATION FOR SEQ ID NO:2818: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2818 (2) INFORMATION FOR SEQ ID NO:2819: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2819 (2) INFORMATION FOR SEQ ID NO:1: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1108 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:1: 1 cagctgtccc tccccactgc catttattcc ttccttcatt caaaccttat gtggctgcta 61 cttaccgtgt gttaagtgtt cacttttttt cttggaattc aaaaaaagaa ggacagtatt 121 tggggcacag atcttttggt gttctataca tttttttaaa gtttcatttt acatttgtgt 181 gtgcgtgtgt gtgtgtgtgt gagacagtct tgctctgttg cccaggctgg agtgcagtgg 241 cataatcatt ggctcactgt agcctcaaag tcctgggccc aagcgatctt cccacctcag 301 ccacccaaaa tgctggggtt acaggtttat gccactctgt ctgacctgaa agttttgggt 361 ttactttccc ttctttctct ttgctgaagt cagagatgat ggcagcttcc agattctctg 421 gtgcctgtgc tgggctcgtg ctggtcatgg tcttgggtcc aggattcatt ctggagactc 481 tcagggaagt ttcccatgac aaggaaatgt aggagagtgt gctggctttg cgtgctcctc 541 tgccaagccc tgcttctcct ggtgggacac actgaaccac agccagggca ttttggtggt 601 tagttaaaaa aaaaaaaaaa aaaaaaaagg aagaagaagg cactgtgtaa ttgtgccggg 661 gatcttcaga aattgtaatg atgaaagagt gcaagctctc acttcccctt cctgtacagg 721 gcaggttgtg cagctggagg cagagcagtc ctctctgggg agcctgaagc aaacatggat 781 caagaaactg taggcaatgt tgtcctgttg gccatcgtca ccctcatcag cgtggtccag 841 aatggtaagg aaagcccttc actcagggaa gaacagaagg ggagattttc tttgatggtt 901 gtttggaagt caggcttaaa caattgtgtc tgtgtgtgcg catgcacaaa cacttttacc 961 ttatctttat tttcttcttt ttatttgaat gtatagggtt gtgtgtattt ctgtgtaaat 1021 ttggggtttt cctcctctta gtctttcact tttgtggtga ttaccagtcc catttttaga 1081 gccagggctg caacttgaag gttttgct (2) INFORMATION FOR SEQ ID NO:2: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 540 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:2: 1 tgcgttttgg gggttcctgg agtatcaatc atggatcaag aaactgtagg caatgttgtc 61 ctgttggcca tcgtcaccct catcagcgtg gtccagaatg gattctttgc ccataaagtg 121 gagcacgaaa gcaggaccca gaatgggagg agcttccaga ggaccggaac acttgccttt 181 gagcgggtct acactgccaa ccagaactgt gtagatgcgt accccacttt cctcgctgtg 241 ctctggtctg cggggctact ttgcagccaa gttcctgctg cgtttgctgg actgatgtac 301 ttgtttgtgc ggcaaaagta ctttgtcggt tacctaggag agagaacgca gagcacccct 361 ggctacatat ttgggaaacg catcatactc ttcctgttcc tcatgtccgt tgctggcata 421 ttcaactatt acctcatctt ctttttcgga agtgactttg aaaactacat aaagacgatc 481 tccaccacca tctcccctct acttctcatt tcctaactct ctgctgaata tggggttggt (2) INFORMATION FOR SEQ ID NO:3: WO 00/09525 PCT/US99/17712 EPI-109 1088 (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 2022 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:3: 1 atgccctcct acacggtcac cgtggccact ggcagccagt ggttcgccgg cactgacgac 61 tacatctacc tcagcctcgt gggctcggcg ggctgcagcg agaagcacct gctggacaag 121 cccttctaca acgacttcga gcgtggcgcg gtggattcat acgacgtgac tgtggacgag 181 gaactgggcg agatccagct ggtcagaatc gagaagcgca agtactggct gaatgacgac 241 tggtacctga agtacatcac gctgaagacg ccccacgggg actacatcga gttcccctgc 301 taccgctgga tcaccggcga tgtcgaggtt gtcctgaggg atggacgcgc aaagttggcc 361 cgagatgacc aaattcacat tctcaagcaa caccgacgta aagaactgga aacacggcaa 421 aaacaatatc gatggatgga gtggaaccct ggcttcccct tgagcatcga tgccaaatgc 481 cacaaggatt taccccgtga tatccagttt gatagtgaaa aaggagtgga ctttgttctg 541 aattactcca aagcgatgga gaacctgttc atcaaccgct tcatgcacat gttccagtct 601 tcttggaatg acttcgccga ctttgagaaa atctttgtca agatcagcaa cactatttct 661 gagcgggtca tgaatcactg gcaggaagac ctgatgtttg gctaccagtt cctgaatggc 721 tgcaaccctg tgttgatccg gcgctgcaca gagctgcccg agaagctccc ggtgaccacg 781 gagatggtag agtgcagcct ggagcggcag ctcagcttgg agcaggaggt ccagcaaggg 841 aacattttca tcgtggactt tgagctgctg gatggcatcg atgccaacaa aacagacccc 901 tgcacactcc agttcctggc cgctcccatc tgcttgctgt ataagaacct ggccaacaag 961 attgtcccca ttgccatcca gctcaaccaa atcccgggag atgagaaccc tattttcctc 1021 ccttcggatg caaaatacga ctggcttttg gccaaaatct gggtgcgttc cagtgacttc 1081 cacgtccacc agaccatcac ccaccttctg cgaacacatc tggtgtctga ggtttttggc 1141 attgcaatgt accgccagct gcctgctgtg caccccattt tcaagctgct ggtggcacac 1201 gtgagattca ccattgcaat caacaccaag gcccgtgagc agctcatctg cgagtgtggc 1261 ctctttgaca aggccaacgc cacagggggc ggtgggcacg tgcagatggt gcagagggcc 1321 atgaaggacc tgacctatgc ctccctgtgc tttcccgagg ccatcaaggc ccggggcatg 1381 gagagcaaag aagacatccc ctactacttc taccgggacg acgggctcct ggtgtgggaa 1441 gccatcagga cgttcacggc cgaggtggta gacatctact acgagggcga ccaggtggtg 1501 gaggaggacc cggagctgca ggacttcgtg aacgatgtct acgtgtacgg catgcggggc 1561 cgcaagtcct caggcttccc caagtcggtc aagagccggg agcagctgtc ggagtacctg 1621 accgtggtga tcttcaccgc ctccgcccag cacgccgcgg tcaacttcgg ccagtacgac 1681 tggtgctcct ggatccccaa tgcgccccca accatgcgag ccccgccacc gactgccaag 1741 ggcgtggtga ccattgagca gatcgtggac acgctgcccg accgcggccg ctcctgctgg 1801 catctgggtg cagtgtgggc gctgagccag ttccaggaaa acgagctgtt cctgggcatg 1861 tacccagaag agcattttat cgagaagcct gtgaaggaag ccatggcccg attccgcaag 1921 aacctcgagg ccattgtcag cgtgattgct gagcgcaaca agaagaagca gctgccatat 1981 tactacttgt ccccagaccg gattccgaac agtgtggcca tc (2) INFORMATION FOR SEQ ID NO:4: (1) SEQUENCE CHARACTERISTICS: (A) LENGTH: 2500 base pairs (H) TYPE: nucleic acid (C) STRANDEDNESS: single (0) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:4: 1gggcccggcg ctcgctgctc ccgcggcccg cgccatgccc tcctacacgg tcaccgtggc 61 cactggcagc cagtggttcg ccggcactga cgactacatc tacctcagcc tcgtgggctc 121 ggcgggctgc agcgagaagc acctgctgga caagcccttc tacaacgact tcgagcgtgg 181 cgcggtggat tcatacgacg tgactgtgga cgaggaactg ggcgagatcc agctggtcag 241 aatcgagaag cgcaagtact ggctgaatga cgactggtac ctgaagtaca tcacgctgaa 301 gacgccccac ggggactaca tcgagttccc ctgctaccgc tggatcaccg gcgatgtcga 361 ggttgtcctg agggatggac gcgcaaagtt ggcccgagat gaccaaattc acattctcaa 421 gcaacaccga ctgaaagaac tggaaacacg gcaaaaacaa tatcgatgga tggagtggaa 481 ccctggcttc cccttgagca tcgatgccaa atgccacaag gatttacccc gtgatatcca 541 gtttgatagt gaaaaaggag tggactttgt tctgaattac tccaaagcga tggagaacct 601 gttcatcaac cgcttcatgc acatgttcca gtcttcttgg aatgacttcg ccgactttga 661 gaaaatcttt gtcaagatca gcaacactat ttctgagcgg gtcatgaatc actggcagga 721 agacctgatg tttggctacc agttcctgaa tggctgcaac cctgtgttga tccggcgctg 781 cacagagctg cccgagaagc tcccggtgac cacggagatg gtagagtgca gcctggagcg 841 gcagctcagc ttggagcagg aggtccagca agggaacatt ttcatcgtgg actttgagct 901 gctggatggc atcgatgcca acaaaacaga cccctgcaca ctccagttcc tggccgctcc 961 catctgcttg ctgtataaga acctggccaa caagattgtc cccattgcca tccagctcaa 1021 ccaaatcccg ggagatgaga accctatttt cctcccttcg gatgcaaaat acgactggct 1081 tttggccaaa atctgggtgc gttccagtga cttccacgtc caccagacca tcacccacct 1141 tctgcgaaca catctggtgt ctgaggtttt tggcattgca atgtaccgcc agctgcctgc 1201 tgtgcacccc attttcaagc tgctggtggc acacgtgaga ttcaccatg caatcaacac WO 00/09525 PCT/US99/17712 EPI-109 1089 1261 caaggcccgt gagcagctca tctgcgagrg tggcctcttt gacaaggcca acgccacagg 1321 gggcggtggg cacgtgcaga tggtgcagag ggccatgaag gacctgacct atgcctccct 1381 gtgctttccc gaggccatca aggcccgggg catggagagc aaagaagaca tcccctacta 1441 cttctaccgg gacgacgggc tcctggtgtg ggaagccatc aggacgttca cggccgaggt 1501 ggtagacatc tactacgagg gcgaccaggt ggtggaggag gacccggagc tgcaggactt 1561 cgtgaacgat gtctacgtgt acggcatgcg gggccgcaag tcctcaggct tccccaagtc 1621 ggtcaagagc cgggagcagc tgtcggagta cctgaccgtg gtgatcttca ccgcctccgc 1681 ccagcacgcc gcggtcaact tcggccagta cgactggtgc tcctggatcc ccaatgcgcc 1741 cccaaccatg cgagccccgc caccgactgc caagggcgtg gtgaccattg agcagatcgt 1801 ggacacgctg cccgaccgcg gccgctcctg ctggcatctg ggtgcagtgt gggcgctgag 1861 ccagttccag gaaaacgagc tgttcctggg catgtaccca gaagagcatt ttatcgagaa 1921 gcctgtgaag gaagccatgg cccgattccg caagaacctc gaggccattg tcagcgtgat 1981 tgctgagcgc aacaagaaga agcagctgcc atattactac ttgtccccag accggattcc 2041 gaacagtgtg gccatctgag cacactgcca gtctcactgt gggaaggcca gctgccccag 2101 ccagatggac tccagcctgc ctggcaggtg tctggccagg cctcttggca gtcacatctc 2161 ttcctccgag gccagtacct ttccatttat tctttgatct tcagggaact gcatagattg 2221 atcaaagtgt aaacaccata gggacccatt ctacacagag caggactgca cagcgtcctg 2281 tccacaccca gctcagcatt tccacaccaa gcagcaacag caaatcacga ccactgatag 2341 atgtctattc ttgttggaga catgggatga ttattttctg ttctatttgt gcttagtcca 2401 attccttgca catagtaggt acccaattca attactattg aatgaattaa gaattggttg 2461 ccataaaaat aaatcagttc atttaaaaaa aaaaaaaaaa (2) INFORMATION FOR SEQ ID NO:5: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 2484 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:5: gggcccggcg ctcgctgctc ccgcggcccg cgccatgccc tcctacacgg tcaccgtggc 61 cactggcagc cagtggttcg ccggcactga cgactacatc tacctcagcc tcgtgggctc 121 ggcgggctgc agcgagaagc acctgctgga caagcccttc tacaacgact tcgagcgtgg 181 cgcggtggat tcatacgacg tgactgtgga cgaggaactg ggcgagatcc agctggtcag 241 aatcgagaag cgcaagtact ggctgaatga cgactggtac ctgaagtaca tcacgctgaa 301 gacgccccac ggggactaca tcgagttccc ctgctaccgc tggatcaccg gcgatgtcga 361 ggttgtcctg agggatggac gcgcaaagtt ggcccgagat gaccaaattc acattctcaa 421 gcaacaccga cgtaaagaac tggaaacacg gcaaaaacaa tatcgatgga tggagtggaa 481 ccctggcttc cccttgagca tcgatgccaa atgccacaag gatttacccc gtgatatcca 541 gtttgatagt gaaaaaggag tggactttgt tctgaattac tccaaagcga tggagaacct 601 gttcatcaac cgcttcatgc acatgttcca gtcttcttgg aatgacttcg ccgactttga 661 gaaaatcttt gtcaagatca gcaacactat ttctgagcgg gtcatgaatc actggcagga 721 agacctgatg tttggctacc agttcctgaa tggctgcaac cctgtgttga tccggcgctg 781 cacagagctg cccgagaagc tcccggtgac cacggagatg gtagagtgca gcctggagcg 841 gcagctcagc ttggagcagg aggtccagca agggaacatt ttcatcgtgg actttgagct 901 gctggatggc atcgatgcca acaaaacaga cccctgcaca ctccagttcc tggccgctcc 961 catctgcttg ctgtataaga acctggccaa caagattgtc cccattgcca tccagctcaa 1021 ccaaatcccg ggagatgaga accctatttt cctcccttcg gatgcaaaat acgactggct 1081 tttggccaaa atctgggtgc gttccagtga cttccacgtc caccagacca tcacccacct 1141 tctgcgaaca catctggtgt ctgaggtttt tggcattgca atgtaccgcc agctgcctgc 1201 tgtgcacccc attttcaagc tgctggtggc acacgtgaga ttcaccattg caatcaacac 1261 caaggcccgt gagcagctca tctgcgagtg tggcctcttt gacaaggcca acgccacagg 1321 gggcggtggg cacgtgcaga tggtgcagag ggccatgaag gacctgacct atgcctccct 1381 gtgctttccc gaggccatca aggcccgggg catggagagc aaagaagaca tcccctacta 1441 cttctaccgg gacgacgggc tcctggtgtg ggaagccatc aggacgttca cggccgaggt 1501 ggtagacatc tactacgagg gcgaccaggt ggtggaggag gacccggagc tgcaggactt 1561 cgtgaacgat gtctacgtgt acggcatgcg gggccgcaag tcctcaggct tccccaagtc 1621 ggtcaagagc cgggagcagc tgtcggagta cctgaccgtg gtgatcttca ccgcctccgc 1681 ccagcacgcc gcggtcaact tcggccagta cgactggtgc tcctggatcc ccaatgcgcc 1741 cccaaccatg cgagccccgc caccgactgc caagggcgtg gtgaccattg agcagatcgt 1801a ggacacgctg cccgaccgcg gccgctcctg ctggcatctg ggtgcagtgt gggcgctgag 1861 ccagttccag gaaaacgagc tgttcctggg catgtaccca gaagagcatt ttatcgagaa 1921 gcctgtgaag gaagccatgg cccgattccg caagaacctc gaggccattg tcagcgtgat 1981 tgctgagcgc aacaagaaga agcagctgcc atattactac ttgtccccag accggattcc 2041 gaacagtgtg gccatctgag cacactgcca gtctcactgt gggaaggcca gctgccccag 2101 ccagatggac tccagcctgc ctggcaggtg tctggccagg cctcttggca gtcacatctc 2161 ttcctccgag gccagtacct ttccatttat tctttgatct tcagggaact gcatagattg 2221 atcaaagtgt aaacaccata gggacccatt ctacacagag caggactgca cagcgtcctg 2281 tccacaccca gctcagcatt tccacaccaa gcagcaacag caaatcacga ccactgatag 2341 atgtctattc ttgttggaga catgggatga ttattttctg ttctatttgt gcttagtcca WO 00/09525 PCT/US99/17712 EPI-109 1090 2401 attccttgca catagtaggt acccaattca attactattg aatgaattaa gaattggttg 2461 ccataaaaat aaatcagttc attt (2) INFORMATION FOR SEQ ID NO:6: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 2497 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:6: 1 gggcgccgag gctccccgcc gctcgctgct ccccggcccg cgccatgccc tcctacacgg 61 tcaccgtggc cactggcagc cagtggttcg ccggcactga cgactacatc tacctcagcc 121 tcgtgggctc ggcgggctgc agcgagaagc acctgctgga caagcccttc tacaacgact 181 tcgagcgtgg cgcggtggat tcatacgacg tgactgtgga cgaggaactg ggcgagatcc 241 agctggtcag aatcgagaag cgcaagtact ggctgaatga cgactggtac ctgaagtaca 301 tcacgctgaa gacgccccac ggggactaca tcgagttccc ctgctaccgc tggatcaccg 361 gcgatgtcga ggttgtcctg agggatggac gcgcaaagtt ggcccgagat gaccaaattc 421 acattctcaa gcaacaccga cgtaaagaac tggaaacacg gcaaaaacaa tatcgatgga 481 tggagtggaa ccctggcttc cccttgagca tcgatgccaa atgccacaag gatttacccc 541 gtgatatcca gtttgatagr gaaaaaggag tggactttgt tctgaattac tccaaagcga 601 tggagaacct gttcatcaac cgcttcatgc acatgttcca gtcttcttgg aatgacttcg 661 ccgactttga gaaaatcttt gtcaagatca gcaacactat ttctgagcgg gtcatgaatc 721 actggcagga agacctgatg tttggctacc agttcctgaa tggctgcaac cctgtgttga 781 tccggcgctg cacagagctg cccgagaagc tcccggtgac cacggagatg gtagagtgca 841 gcctggagcg gcagctcagc ttggagcagg aggtccagca agggaacatt ttcatcgtgg 901 actttgagct gctggatggc atcgatgcca acaaaacaga cccctgcaca ctccagttcc 961 tggccgctcc catctgcttg ctgtataaga acctggccaa caagattgtc cccattgcca 1021 tccagctcaa ccaaatcccg ggagatgaga accctatttt cctcccttcg gatgcaaaat 1081 acgactggct tttggccaaa atctgggtgc gttccagtga cttccacgtc caccagacca 1141 tcacccacct tctgcgaaca catctggtgt ctgaggtttt tggcattgca atgtaccgcc 1201 agctgcctgc tgtgcacccc attttcaagc tgctggtggc acacgtgaga ttcaccattg 1261 caatcaacac caaggcccgt gagcagctca tctgcgagtg tggcctcttt gacaaggcca 1321 acgccacagg gggcggtggg cacgtgcaga tggtgcagag ggccatgaag gacctgacct 1381 atgcctccct gtgctttccc gaggccatca aggcccgggg catggagagc aaagaagaca 1441 tcccctacta cttctaccgg gacgacgggc tcctggtgtg ggaagccatc aggacgttca 1501 cggccgaggt ggtagacatc tactacgagg gcgaccaggt ggtggaggag gacccggagc 1561 tgcaggactt cgtgaacgat gtctacgtgt acggcatgcg gggccgcaag tcctcaggct 1621 tccccaagtc ggtcaagagc cgggagcagc tgtcggagta cctgaccgtg gtgatcttca 1681 ccgcctccgc ccagcacgcc gcggtcaact tcggccagta cgactggtgc tcctggatcc 1741 ccaatgcgcc cccaaccatg cgagccccgc caccgactgc caagggcgtg gtgaccattg 1801 agcagatcgt ggacacgctg cccgaccgcg gccgctcctg ctggcatctg ggtgcagtgt 1861 gggcgctgag ccagttccag gaaaacgagc tgttcctggg catgtaccca gaagagcatt 1921 ttatcgagaa gcctgtgaag gaagccatgg cccgattccg caagaacctc gaggccattg 1981 tcagcgtgat tgctgagcgc aacaagaaga agcagctgcc atattactac ttgtccccag 2041 accggattcc gaacagtgtg gccatctgag cacactgcca gtctcactgt gggaaggcca 2101 gctgccccag ccagatggac tccagcctgc ctggcaggct gtctggccag gcctcttggc 2161 agtcacatct cttcctccga ggccagtacc tttccattta ttctttgatc ttcagggaac 2221 tgcatagatt gtatcaaagt gtaaacacca tagggaccca ttctacacag agcaggactg 2281 cacaggcgtc ctgtccacac ccagctcagc atttccacac caagcagcaa cagcaaatca 2341 cgaccactga tagatgtcta ttcttgttgg agacatggga tgattatttt ctgttctatt 2401 tgtgcttagt ccaattcctt gcacatagca ggtacccaat tcaattacta ttgaatgaat 2461 taagaattgg ttgccataaa aataaatcag ttcattt (2) INFORMATION FOR SEQ ID NO:7: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 10151 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:7: 1 cagctgtccc tccccactgc catttattcc ttccttcat caaaccttat gtggctgcta 61 cttaccgtgt gttaagtgtt cacttttttt ctggaattc aaaaaaagaa ggacagtatt 121 tggggcacag atcttttgga gttctataca tttttttaaa gtttcatttt acatttgtgt 181 gtgcgtgtgt gtgtgtgtgt gagacagtca tgctctgttg cccaggctgg agtgcagtgg 241 cataatcatt ggctcactgt agcctcaaag tcctgggccc aagcgatctt cccacctcag 301 ccacccaaaa tgctggggtt acaggtttat gccactctgt ctgacctgaa agttttgggt 361 ttactttccc ttctttctc ttgctgaagt cagagatgac ggcagcttcc agattctctg 421 gtgcctgtgc gggctcgtg ctggtcatgg tctgggtcc aggattcatt ctggagactc 481 tcagggaagt ttcccatgac aaggaaatgt aggagagtg gctggctttg cgtgctccc WO 00/09525 PCT/US99/17712 EPI-109 1091 541 tgccaagccc tgcttctcct ggtgggacac actgaaccac agccagggca ttttggtggt 601 tagttaaaaa aaaaaaaaaa aaaaaaaagg aagaagaagg cactgtgtaa ttgtgccggg 661 gatcttcaga aattgtaatg atgaaagagt gcaagctctc acttcccctt cctgtacagg 721 gcaggttgtg cagctggagg cagagcagtc ctctctgggg agcctgaagc aaacatggat 781 caagaaactg taggcaatgt tgtcctgttg gccatcgtca ccctcatcag cgtggtccag 841 aatggtaagg aaagcccttc actcagggaa gaacagaagg ggagattttc tttgatggtt 901 gtttggaagt caggcttaaa caattgtgtc tgtgtgtgcg catgcacaaa cacttttacc 961 ttatctttat tttcttcttt ttatttgaat gtatagggtt gtgtgtattt ctgtgtaaat 1021 ttggggtttt cctcctctta gtctttcact tttgtggtga ttaccagtcc catttttaga 1081 gccagggctg caacttgaag gttttgct 1 tgcgttttgg gggttcctgg agtatcaatc atggatcaag aaactgtagg caatgttgtc 61 ctgttggcca tcgtcaccct catcagcgtg gtccagaatg gattctttgc ccataaagtg 121 gagcacgaaa gcaggaccca gaatgggagg agcttccaga ggaccggaac acttgccttt 181 gagcgggtct acactgccaa ccagaactgt gtagatgcgt accccacttt cctcgctgtg 241 ctctggtctg cggggctact ttgcagccaa gttcctgctg cgtttgctgg actgatgtac 301 ttgtttgtgc ggcaaaagta ctttgtcggt tacctaggag agagaacgca gagcacccct 361 ggctacatat ttgggaaacg catcatactc ttcctgttcc tcatgtccgt tgctggcata 421 ttcaactatt acctcatctt ctttttcgga agtgactttg aaaactacat aaagacgatc 481 tccaccacca tctcccctct acttctcatt tcctaactct ctgctgaata tggggttggt 1 atgccctcct acacggtcac cgtggccact ggcagccagt ggttcgccgg cactgacgac 61 tacatctacc tcagcctcgt gggctcggcg ggctgcagcg agaagcacct gctggacaag 121 cccttctaca acgacttcga gcgtggcgcg gtggattcat acgacgtgac tgtggacgag 181 gaactgggcg agatccagc.t ggtcagaatc gagaagcgca agtactggct gaatgacgac 241 tggtacctga agtacatcac gctgaagacg ccccacgggg actacatcga gttcccctgc 301 taccgctgga tcaccggcga tgtcgaggtt gtcctgaggg atggacgcgc aaagttggcc 361 cgagatgacc aaattcacat tctcaagcaa caccgacgta aagaactgga aacacggcaa 421 aaacaatatc gatggatgga gtggaaccct ggcttcccct tgagcatcga tgccaaatgc 481 cacaaggatt taccccgtga tatccagttt gatagtgaaa aaggagtgga ctttgttctg 541 aattactcca aagcgatgga gaacctgttc atcaaccgct tcatgcacat gttccagtct 601 tcttggaatg acttcgccga ctttgagaaa atctttgtca agatcagcaa cactatttct 661 gagcgggtca tgaatcactg gcaggaagac ctgatgtttg gctaccagtt cctgaatggc 721 tgcaaccctg tgttgatccg gcgctgcaca gagctgcccg agaagctccc ggtgaccacg 781 gagatggtag agtgcagcct ggagcggcag ctcagcttgg agcaggaggt ccagcaaggg 841 aacattttca tcgtggactt tgagctgctg gatggcatcg atgccaacaa aacagacccc 901 tgcacactcc agttcctggc cgctcccatc tgcttgctgt ataagaacct ggccaacaag 961 attgtcccca ttgccatcca gctcaaccaa atcccgggag atgagaaccc tattttcctc 1021 ccttcggatg caaaatacga ctggcttttg gccaaaatct gggtgcgttc cagtgacttc 1081 cacgtccacc agaccatcac ccaccttctg cgaacacatc tggtgtctga ggtttttggc 1141 attgcaatgt accgccagct gcctgctgtg caccccattt tcaagctgct ggtggcacac 1201 gtgagattca ccattgcaat caacaccaag gcccgtgagc agctcatctg cgagtgtggc 1261 ctctttgaca aggccaacgc cacagggggc ggtgggcacg tgcagatggt gcagagggcc 1321 atgaaggacc tgacctatgc ctccctgtgc tttcccgagg ccatcaaggc ccggggcatg 1381 gagagcaaag aagacatccc ctactacttc taccgggacg acgggctcct ggtgtgggaa 1441 gccatcagga cgttcacggc cgaggtggta gacatctact acgagggcga ccaggtggtg 1501 gaggaggacc cggagctgca ggacttcgtg aacgatgtct acgtgtacgg catgcggggc 1561 cgcaagtcct caggcttccc caagtcggtc aagagccggg agcagctgtc ggagtacctg 1621 accgtggtga tcttcaccgc ctccgcccag cacgccgcgg tcaacttcgg ccagtacgac 1681 tggtgctcct ggatccccaa tgcgccccca accatgcgag ccccgccacc gactgccaag 1741 ggcgtggtga ccattgagca gatcgtggac acgctgcccg accgcggccg ctcctgctgg 1801 catctgggtg cagtgtgggc gctgagccag ttccaggaaa acqagctgtt cctgggcatg 1861 tacccagaag agcattttat cgagaagcct gtgaaggaag ccatggcccg attccgcaag 1921 aacctcgagg ccattgtcag cgtgattgct gagcgcaaca agaagaagca gctgccatat 1981 tactacttgt ccccagaccg gattccgaac agtgtggcca tc tgggcccggcg ctcgctgctc ccgcggcccg cgccatgccc tcctacacgg tcaccgtggc 61 cactggcagc cagtggttcg ccggcactga cgactacatc tacctcagcc tcgtgggctc 121 ggcgggctgc agcgagaagc acctgctgga caagcccttc tacaacgact tcgagcgtgg 181 cgcggtggat tcatacgacg tgactgtgga cgaggaactg ggcgagatcc agctggtcag 241 aatcgagaag cgcaagtact ggctgaatga cgactggtac ctgaagtaca tcacgctgaa 301 gacgccccac ggggactaca tcgagttccc ctgctaccgc tggatcaccg gcgatgtcga 361 ggttgtcctg agggatqgac gcgcaaagtt ggcccgagat gaccaaattc acattctcaa 421 gcaacaccga ctgaaagaac tggaaacacg gcaaaaacaa tatcgatgga tggagtggaa 481 ccctggcttc cccttgagca tcgatgccaa atgccacaag gatttacccc gtgatatcca 541 gtttgatagt gaaaaaggag tggactttgt tctgaattac tccaaagcga tggagaacct 601 gttcatcaac cgcttcatgc acatgttcca gtcttcttgg aatgacttcg ccgactttga 661 gaaaatcttt gtcaagatca gcaacactat ttctgagcgg gtcatgaatc actggcagga 721 agacctgatg tttggctacc agttcctgaa tggctgcaac cctgtgttga tccggcgctg 781 cacagagctg cccgagaagc tcccggtgac cacggagatg gtagagtgca gcctggagcg 841 gcagctcagc ttggagcagg aggtccagca agggaacatt ttcatcgtgg actttgagct WO 00/09525 PCT/US99/17712 EPI-109 1092 901 gcrggatggc atcgatgcca acaaaacaga cccctgcaca ctccagttcc tggccgctcc 961 catctgcttg ctgtataaga acctggccaa caagattgtc cccattgcca tccagctcaa 1021 ccaaatcccg ggagatgaga accctatttt cctcccttcg gatgcaaaat acgactggct 1081 tttggccaaa atctgggtgc gttccagtga cttccacgtc caccagacca tcacccacct 1141 tctgcgaaca catctggtgt ctgaggtttt tggcattgca atgtaccgcc agctgcctgc 1201 tgtgcacccc attttcaagc tgctggtggc acacgtgaga ttcaccattg caatcaacac 1261 caaggcccgt gagcagctca tctgcgagtg tggcctcttt gacaaqgcca acgccacagg 1321 gggcggtggg cacgtgcaga tggtgcagag ggccatgaag gacctgacct atgcctccct 1381 gtgctttccc gaggccatca aggcccgggg catggagagc aaagaagaca tcccctacta 1441 cttctaccgg gacgacgggc tcctggtgtg ggaagccatc aggacgttca cggccgaggt 1501 ggtagacatc tactacgagg gcgaccaggt ggtggaggag gacccggagc tgcaggactt 1561 cgtgaacgat gtctacgtgt acggcatgcg gggccgcaag tcctcaggct tccccaagtc 1621 ggtcaagagc cgggagcagc tgtcggagta cctgaccgtg gtgatcttca ccgcctccgc 1681 ccagcacgcc gcggtcaact tcggccagta cgactggtgc tcctggatcc ccaatgcgcc 1741 cccaaccatg cgagccccgc caccgactgc caagggcgtg gtgaccattg agcagatcgt 1801 ggacacgctg cccgaccgcg gccgctcctg ctggcatctg ggtgcagtgt gggcgctgag 1861 ccagttccag gaaaacgagc tgttcctggg catgtaccca gaagagcatt ttatcgagaa 1921 gcctgtgaag gaagccatgg cccgattccg caagaacctc gaggccattg tcagcgtgat 1981 tgctgagcgc aacaagaaga agcagctgcc atattactac ttgtccccag accggattcc 2041 gaacagtgtg gccatctgag cacactgcca gtctcactgt gggaaggcca gctgccccag 2101 ccagatggac tccagcctgc ctggcaggtg tctggccagg cctcttggca gtcacatctc 2161 ttcctccgag gccagtacct ttccatttat tctttgatct tcagggaact gcatagattg 2221 atcaaagtgt aaacaccata gggacccatt ctacacagag caggactgca cagcgtcctg 2281 tccacaccca gctcagcatt tccacaccaa gcagcaacag caaatcacga ccactgatag 2341 atgtctattc ttgttggaga catgggatga ttattttctg ttctatttgt gcttagtcca 2401 attccttgca catagtaggt acccaattca attactattg aatgaattaa gaattggttg 2461 ccataaaaat aaatcagttc atttaaaaaa aaaaaaaaaa 1 gggcccggcg ctcgctgctc ccgcggcccg cgccatgccc tcctacacgg tcaccgtggc 61 cactggcagc cagtggttcg ccggcactga cgactacatc tacctcagcc tcgtgggctc 121 ggcgggctgc agcgagaagc acctgctgga caagcccttc tacaacgact tcgagcgtgg 181 cgcggtggat tcatacgacg tgactgtgga cgaggaactg ggcgagatcc agctggtcag 241 aatcgagaag cgcaagtact ggctgaatga cgactggtac ctgaagtaca tcacgctgaa 301 gacgccccac ggggactaca tcgagttccc ctgctaccgc tggatcaccg gcgatgtcga 361 ggttgtcctg agggatggac gcgcaaagtt ggcccgagat gaccaaattc acattctcaa 421 gcaacaccga cgtaaagaac tggaaacacg gcaaaaacaa tatcgatgga tggagtggaa 481 ccctggcttc cccttgagca tcgatgccaa atgccacaag gatttacccc gtgatatcca 541 gtttgatagt gaaaaaggag tggactttgt tctgaattac tccaaagcga tggagaacct 601 gttcatcaac cgcttcatgc acatgttcca gtcttcttgg aatgacttcg ccgactttga 661 gaaaatcttt gtcaagatca gcaacactat ttctgagcgg gtcatgaatc actggcagga 721 agacctgatg tttggctacc agttcctgaa tggctgcaac cctgtgttga tccggcgctg 781 cacagagctg cccgagaagc tcccggtgac cacggagatg gtagagtgca gcctggagcg 841 gcagctcagc ttggagcagg aggtccagca agggaacatt ttcatcgtgg actttgagct 901 gctggatggc atcgatgcca acaaaacaga cccctgcaca ctccagttcc tggccgctcc 961 catctgcttg ctgtataaga acctggccaa caagattgtc cccattgcca tccagctcaa 1021 ccaaatcccg ggagatgaga accctatttt cctcccttcg gatgcaaaat acgactggct 1081 tttggccaaa atctgggtgc gttccagtga cttccacgtc caccagacca tcacccacct 1141 tctgcgaaca catctggtgt ctgaggtttt tggcattgca atgtaccgcc agctgcctgc 1201 tgtgcacccc attttcaagc tgctggtggc acacgtgaga ttcaccattg caatcaacac 1261 caaggcccgt gagcagctca tctgcgagtg tggcctcttt gacaaggcca acgccacagg 1321 gggcggtggg cacgtgcaga tggtgcagag ggccatgaag gacctgacct atgcctccct 1381 gtgctttccc gaggccatca aggcccgggg catggagagc aaagaagaca tcccctacta 1441 cttctaccgg gacgacgggc tcctggtgtg ggaagccatc aggacgttca cggccgaggt 1501 ggtagacatc tactacgagg gcgaccaggt ggtggaggag gacccggagc tgcaggactt 1561 cgtgaacgat gtctacgtgt acggcatgcg gggccgcaag tcctcaggct tccccaagtc 1621 ggtcaagagc cgggagcagc tgtcggagta cctgaccgtg gtgatcttca ccgcctccgc 1681 ccagcacgcc gcggtcaact tcggccagta cgactggtgc tcctggatcc ccaatgcgcc 1741 cccaaccatg cgagccccgc caccgactgc caagggcgtg gtgaccattg agcagatcgt 1801 ggacacgctg cccgaccgcg gccgctcctg ctggcatctg ggtgcagtgt gggcgctgag 1861 ccagttccag gaaaacgagc tgttcctggg catgtaccca gaagagcatt ttatcgagaa 1921 gcctgtgaag gaagccatgg cccgattccg caagaacctc gaggccattg tcagcgtgat 1981 tgctgagcgc aacaagaaga agcagctgcc atattactac ttgtccccag accggattcc 2041 gaacagtgtg gccatctgag cacactgcca gtctcactgt gggaaggcca gctgccccag 2101 ccagatggac tccagcctgc ctggcaggtg tctggccagg cctcttggca gtcacatctc 2161 ttcctccgag gccagtacct ttccatttat tctttgatct tcagggaact gcatagattg 2221 atcaaagtgt aaacaccata gggacccatt ctacacagag caggactgca cagcgtcctg 2281 tccacaccca gctcagcatt tccacaccaa gcagcaacag caaatcacga ccactgatag 2341 atgtctattc ttgttggaga catgggatga ttattttctg ttctattigt gcttagtcca 2401 attccttgca catagtaggt acccaattca attactattg aatgaattaa gaattggttg WO 00/09525 PCT/US99/17712 EPI-109 1093 2461 ccataaaaat aaatcagttc attt 1 gggcgccgag gctccccgcc gctcgctgct ccccggcccg cgccatgccc tcctacacgg 61 tcaccgtggc cactggcagc cagtggttcg ccggcactga cgactacatc tacctcagcc 121 tcgtgggctc ggcgggctgc agcgagaagc acctgctgga caagcccttc tacaacgact 181 tcgagcgtgg cgcggtggat tcatacgacg tgactgtgga cgaggaactg ggcgagatcc 241 agctggtcag aatcgagaag cgcaagtact ggctgaatga cgactggtac ctgaagtaca 301 tcacgctgaa gacgccccac ggggactaca tcgagttccc ctgctaccgc tggatcaccg 361 gcgatgtcga ggttgtcctg agggatggac gcgcaaagtt ggcccgagat gaccaaattc 421 acattctcaa gcaacaccga cgtaaagaac tggaaacacg gcaaaaacaa tatcgatgga 481 tggagtggaa ccctggcttc cccttgagca tcgatgccaa atgccacaag gatttacccc 541 gtgatatcca gtttgatagt gaaaaaggag tggactttgt tctgaattac tccaaagcga 601 tggagaacct gttcatcaac cgcttcatgc acatgttcca gtcttcttgg aatgacttcg 661 ccgactttga gaaaatcttt gtcaagatca gcaacactat ttctgagcgg gtcatgaatc 721 actggcagga agacctgatg tttggctacc agttcctgaa tggctgcaac cctgtgttga 781 tccggcgctg cacagagctg cccgagaagc tcccggtgac cacggagatg gtagagtgca 841 gcctggagcg gcagctcagc ttggagcagg aggtccagca agggaacatt ttcatcgtgg 901 actttgagct gctggatggc atcgatgcca acaaaacaga cccctgcaca ctccagttcc 961 tggccgctcc catctgcttg ctgtataaga acctggccaa caagattgtc cccattgcca 1021 tccagctcaa ccaaatcccg ggagatgaga accctatttt cctcccttcg gatgcaaaat 1081 acgactggct tttggccaaa atctgggtgc gttccagtga cttccacgtc caccagacca 1141 tcacccacct tctgcgaaca catctggtgt ctgaggtttt tggcattgca atgtaccgcc 1201 agctgcctgc tgtgcacccc attttcaagc tgctggtggc acacgtgaga ttcaccattg 1261 caatcaacac caaggcccgt gagcagctca tctgcgagtg tggcctcttt gacaaggcca 1321 acgccacagg gggcggtggg cacgtgcaga tggtgcagag ggccatgaag gacctgacct 1381 atgcctccct gtgctttccc gaggccatca aggcccgggg catggagagc aaagaagaca 1441 tcccctacta cttctaccgg gacgacgggc tcctggtgtg ggaagccatc aggacgttca 1501 cggccgaggt ggtagacatc tactacgagg gcgaccaggt ggtggaggag gacccggagc 1561 tgcaggactt cgtgaacgat gtctacgtgt acggcatgcg gggccgcaag tcctcaggct 1621 tccccaagtc ggtcaagagc cgggagcagc tgtcggagta cctgaccgtg gtgatcttca 1681 ccgcctccgc ccagcacgcc gcggtcaact tcggccagta cgactggtgc tcctggatcc 1741 ccaatgcgcc cccaaccatg cgagccccgc caccgactgc caagggcgtg gtgaccattg 1801 agcagatcgt ggacacgctg cccgaccgcg gccgctcctg ctggcatctg ggtgcagtgt 1861 gggcgctgag ccagttccag gaaaacgagc tgttcctggg catgtaccca gaagagcatt 1921 ttatcgagaa gcctgtgaag gaagccatgg cccgattccg caagaacctc gaggccattg 1981 tcagcgtgat tgctgagcgc aacaagaaga agcagctgcc atattactac ttgtccccag 2041 accggattcc gaacagtgtg gccatctgag cacactgcca gtctcactgt gggaaggcca 2101 gctgccccag ccagatggac tccagcctgc ctggcaggct gtctggccag gcctcttggc 2161 agtcacatct cttcctccga ggccagtacc tttccattta ttctttgatc ttcagggaac 2221 tgcatagatt gtatcaaagt gtaaacacca tagggaccca ttctacacag agcaggactg 2281 cacaggcgtc ctgtccacac ccagctcagc atttccacac caagcagcaa cagcaaatca 2341 cgaccactga tagatgtcta ttcttgttgg agacatggga tgattatttt ctgttctatt 2401 tgtgcttagt ccaattcctt gcacatagta ggtacccaat tcaattacta ttgaatgaat 2461 taagaattgg ttgccataaa aataaatcag ttcattt (2) INFORMATION FOR SEQ ID NO:8: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 2383 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:8: 1ggcacgaggc tggctgagcc atgatgctgc tgccagaacc cctgcagagg gcctggtttc 61 aggagactca gagtcctctg tgaaaaagcc cttggagagg cgccccagca gggctgcact 121 tggctcctgt gaggaagggg ctcagggtct gggcccctcc gcctgggccg ggctgggagc 181 caggcgggcg gctgggctgc agcaatggac cgtgagctgg cccagcccgc gtccgtgctg 241 agcctgcctg tcgtctgtgg ccatgccatc atgggctcct cggtgtacat cacggtggag 301 ctggccattg ctgtgctggc catcctgggc aatgtgctgg tgtgctgggc cgtgtggctc 361 aacagcaacc tgcagaacgt caccaactac tttgtggtgt cactggcggc ggccgacatc 421 gcagtgggtg tgctcgccat cccctttgcc atcaccatca gcaccgggtt ctgcgctgcc 481 tgccacggct gcctcttcat tgcctgcttc gtcctggtcc tcacgcagag ctccatcttc 541 agtctcctgg ccatcgccat tgaccgctac attgccatcc gcatcccgct ccggtacaat 601 ggcttggtga ccggcacgag ggctaagggc atcattgcca tctgctgggt gctgtcgttt 661 gccatcggcc tgactcccat gctaggttgg aacaactgcg gtcagccaaa ggagggcaag 721 aaccactccc agggctgcgg ggagggccaa gtggcctgtc tctttgagga tgtggtcccc 781 atgaactaca tggtgtactt caacttcttt gcctgtgtgc tggtgcccct gctgctcatg 841 ctgggtgtct atttgcggat cttcctggcg gcgcgacgac agctgaagca gatggagagc 901 cagcctctgc cgggggagcg ggcacggtcc acactgcaga aggaggtcca tgctgccaag 961 tcactggcca tcattgtggg gctctttgcc ctctgctggc tgcccctaca catcatcaac 1021 tgcttcactt tcttctgccc cgactgcagc cacgcccctc tctggctcat gtacctggcc WO 00/09525 PCT/US99/17712 EPI-109 1094 1081 atcgtcctct cccacaccaa ttcggttgtg aatcccttca tctacgccta ccgtatccgc 1141 gagttccgcc agaccttccg caagatcatt cgcagccacg tcctgaggca gcaagaacct 1201 ttcaaggcag ctggcaccag tgcccgggtc ttggcagctc atggcagtga cggagagcag 1261 gtcagcctcc gtctcaacgg ccacccgcca ggagtgtggg ccaacggcag tgctccccac 1321 cctgagcgga ggcccaatgg ctatgccctg gggctggtga gtggagggag tgcccaagag 1381 tcccagggga acacgggcct cccagacgtg gagctcctta gccatgagct caagggagtg 1441 tgcccagagc cccctggcct agatgacccc ctggcccagg atggagcagg agtgtcctga 1501 tgattcatgg agtttgcccc ttcctaaggg aaggagatct ttatctttct ggttggcttg 1561 accagtcacg ttgggagaag agagagagtg ccaggagacc ctgagggcag ccggttccta 1621 ctttggactg agagaaggga gccccaggct ggagcagcat gaggcccagc aagaagggct 1681 tgggttctga ggaagcagat gtttcatgct gtgaggcctt gcaccaggtg ggggccacag 1741 caccagcagc atctttgctg ggcagggccc agccctccac tgcagaagca tctggaagca 1801 ccaccttgtc tccacagagc agcttgggca cagcagactq gcctggccct gagactgggg 1861 agtggctcca acagcctcct gccacccaca caccactctc cctagactct cctagggttc 1921 aggagctgct gggcccagag gtgacatttg acttttttcc aggaaaaatg taagtgtgag 1981 gaaacccttt ttattttatt acctttcact ctctggctgc tgggtctgcc gtcggtcctg 2041 ctgctaacct ggcaccagag cctctgccgg ggagcctcag gcagtcctct cctgctgtca 2101 cagctgccat ccacttctca gtcccagggc catctcttgg agtgacaaag ctgggatcaa 2161 ggacagggag ttgtaacaga gcagtgccag agcatgggcc caggtcccag gggagaggtt 2221 ggggctggca ggccactggc atgtgctgag tagcgcagag ctacccagtg agaggccttg 2281 tctaactgcc tttccttcta aagggaatgt ttttttctga gataaaataa aaacgagcca 2341 catcgtgttt taagcttgtc caaatgaaaa aaaaaaaaaa aaa (2) INFORMATION FOR SEQ ID NO:9: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 2988 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:9: 1 catcaccttt ttttaagtag taagaataaa gccactgtat gattctctta atagctatac 61 attaatcctg tttttaggc tgactgggcc agccttccgg gaactggagt ctgtctcttt 121 cagtgctttt ttgttttttg ttggtttttt cgagacgggg tcgatcacgg ctcaccacag 181 ccttaacctc cagggctcca gcaatcctcc cacctcagcc tcctgagtag ctgggaccac 241 aggtgtgtgc caccatctcc agcagtttgt ttatttattt tttctttttt tttttttggt 301 agaaatgggc ttttcgccca tgttgcccaa gctggtcttg cacttctggg ctgaagcaat 361 cctctcgcct tggcctccca gagccttggg attacagaat catgggtgag agctggcatg 421 gcccctagag gtcatttggg gtccagctgc ctcaccgtat caatgaggaa actgaggccc 481 agaaaagaaa agcatttttg cccagagtcc ctcagaaaaa aacagaccac atctgatcct 541 tggccctgag tccagagtgg gaggcaccgt gacaacaatg cgcagagcag ggaatgcagg 601 gagccatgga tagtgctggg gtgcctcagg aaccctgaag ctgggctgag ccatgatgct 661 gctgccagaa cccctgcaga gggcctggtt tcaggagact cagagtcctc tgtgaaaaag 721 cccttggaga gcgccccagc agggctgcac ttggctcctg tgaggaaggg gctcaggggt 781 ctgggcccct ccgcctgggc cgggctggga gccaggcggg cggctgggct gcagcaatgg 841 accgtgagct ggcccagccc gcgtccgtgc tgagcctgcc tgtcgtctgt ggcatgccca 901 tcatgggctc ctcggtgca 'c atcacggtgg agctggccat tgctgtgctg gccatcctgg 961 gcaatgtgct ggtgtgctgg gccgtgtggc tcaacagcaa cctgcagaac gtcaccaact 1021 actttgtggt gtcactggcg gcggccgaca tcgcagtggg tgtgctcgcc atcccctttg 1081 ccatcaccat cagcaccggg ttctgcgctg cctgccacgg ctgcctcttc attgcctgct 1141 tcgtcctggt cctcacgcag agctccatct tcagtctcct ggccatcgcc attgaccgct 1201 acattgccat ccgcatcccg ctccggtaca atggcttggt gaccggcacg agggctaagg 1261 gcatcattgc catctgctgg gtgctgtcgt ttgccatcgg cctgactccc atgctaggtt 1321 ggaacaactg cggtcagcca aaggagggca agaaccactc ccagggctgc ggggagggcc 1381 aagtggcctg tctctttgag gatgtggtcc ccatgaacta catggtgtac ttcaacttct 1441 ttgcctgtgt gctggtgccc ctgctgctca tgctgggtgt ctatttgcgg atcttcctgg 1501 cggcgcgacg acagctgaag cagatggaga gccagcctct gccgggggag cgggcacggt 1561 ccacactgca gaaggaggtc catgctgcca agtcactggc catcattgtg gggctctttg 1621 ccctctgctg gctgccccta cacatcatca actgcttcac tttcttctgc cccgactgca 1681 gccacgcccc tctctggctc atgtacctgg ccatcgtcct ctcccacacc aattcggttg 1741 tgaatccctt catctacgcc taccgtatcc gcgagttccg ccagaccttc cgcaagatca 1801 ttcgcagcca cgtcctgagg cagcaagaac ctttcaaggc agctggcacc agtgcccggg 1861 tcttggcagc tcatggcagt gacggagagc aggtcagcct ccgtctcaac ggccacccgc 1921 caggagtgtg ggccaacggc agtgctcccc accctgagcg gaggcccaat ggctatgccc 1981 tggggctggt gagtggaggg agtgcccaag agtcccaggg gaacacgggc ctcccagacg 2041 tggagctcct tagccatgag ctcaagggag tgtgcccaga gccccctggc ctagatgacc 2101 ccctggccca ggatggagca ggagtgtcct gatgattcat ggagtttgcc ccttcctaag 2161 ggaaggagat ctttatcttt ctggttggct tgaccagcca cgttgggaga agagagagag 2221 tgccaggaga ccctgagggc agccggttcc tactttggac tgagagaagg gagccccagg 2281 ctggagcagc atgaggccca gcaagaaggg cttgggttct gaggaagcag atgtttcatg WO 00/09525 PCT/US99/17712 EPI-109 1095 2341 ctgtgaggcc ttgcaccagg tgggggccac agcaccagca gcagcatctt tctgggcagg 2401 cccagccctc cactgcagaa gcatctggaa gcaccacctt gtctccacag agcagcttgg 2461 gcacagcaga ctggcctggc cctgagactg gggagtggct ccaacagcct cctgccaccc 2521 acacaccact ctccctagac tctcctaggg ttcaggagct gctgggccca gaggtgacat 2581 ttgacttttt tccaggaaaa atgtaagtgt gaggaaaccc cttttatttt attacctttc 2641 actctctggc tgctgggtct gccgtcggtc ctgctgctaa cctggcagca gagcctctgc 2701 ccggggagcc tcaggcagtc ctctcctgct gtcacagctg ccatccactt ctcagtccca 2761 gggccatctc ttggagtgac aaagctggga tcaaggacag ggagttgtaa cagagcagtg 2821 ccagagcatg ggcccaggtc ccaggggaga ggttggggct ggcaggccac tggcatgtgc 2881 tgagtagcgc agagctaccc agtgagaggc cttgtctaac tgcctttcct tctaaaggga 2941 atgttttttt ctgagataaa ataaaaacga gccacatcgt gttttaag (2) INFORMATION FOR SEQ ID NO:10: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 2157 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:10: 1 ggcacgagcc cagaaacaaa gacttcacgg acaaagtccc ttggaaccag agagaagccg 61 ggatggaaac tccaaacacc acagaggact atgacacgac cacagagttt gactatgggg 121 atgcaactcc gtgccagaag gtgaacgaga gggcctttgg ggcccaactg ctgccccctc 181 tgtactcctt ggtatttgtc attggcctgg ttggaaacat cctggtggtc ctggtccttg 241 tgcaatacaa gaggctaaaa aacatgacca gcatctacct cctgaacctg gccatttctg 301 acctgctctt cctgttcacg cttcccttct ggatcgacta caagttgaag gatgactggg 361 tttttggtga tgccatgtgt aagatcctct ctgggtttta ttacacaggc ttgtacagcg 421 agatcttttt catcatcctg ctgacgattg acaggtacct ggccatcgtc cacgccgtgt 481 ttgccttgcg ggcacggacc gtcacttttg gtgtcatcac cagcatcatc atttgggccc 541 tggccatctt ggcttccatg ccaggcttat acttttccaa gacccaatgg gaattcactc 601 accacacctg cagccttcac tttcctcacg aaagcctacg agagtggaag ctgtttcagg 661 ctctgaaact gaacctcttt gggctggtat tgcctttgtt ggtcatgatc atctgctaca 721 cagggattat aaagattctg ctaagacgac caaatgagaa gaaatccaaa gctgtccgtt 781 tgatttttgt catcatgatc atcttttttc tcttttggac cccctacaat ttgactatac 841 ttatttctgt tttccaagac ttcctgttca cccatgagtg tgagcagagc agacatttgg 901 acctggctgt gcaagtgacg gaggtgatcg cctacacgca ctgctgtgtc aacccagtga 961 tctacgcctt cgttggtgag aggttccgga agtacctgcg gcagttgttc cacaggcgtg 1021 tggctgtgca cctggttaaa tggctcccct tcctctccgt ggacaggctg gagagggtca 1081 gctccacatc tccctccaca ggggagcatg aactctctgc tgggttctga ctcagaccat 1141 aggaggccaa cccaaaataa gcaggcgtga cctgccaggc acactgagcc agcagcctgg 1201 ctctcccagc caggttctga ctcttggcac agcatggagt cacaqccact tgggatagag 1261 agggaatgta atggtggcct ggggcttctg aggcttctgg ggcttcagtc ttttccatga 1321 acttctcccc tggtagaaag aagatgaatg agcaaaacca aatattccag agactgggac 1381 taagtgtacc agagaagggc ttggactcaa gcaagatttc agatttgtga ccattagcat 1441 ttgtcaacaa agtcacccac ttcccactat tgcttgcaca aaccaattaa acccagtagt 1501 ggtgactgtg ggctccattc aaagtgagct cctaagccat gggagacact gatgtatgag 1561 gaatttctgt tcttccatca cctccccccc cccgccaccc tcccactgcc aagaacttgg 1621 aaatagtgat ttccacagtg actccactct gagtcccaga gccaatcagt agccagcatc 1681 tgcctcccct tcactcccac cgcaggattt gggctcttgg aatcctgggg aacatagaac 1741 tcatgacgga agagttgaga cctaacgaga aatagaaatg ggggaactac tgctggcagt 1801 ggaactaaga aagcccttag gaagaatttt tatatccact aaaatcaaac aattcaggga 1861 gtgggctaag cacgggccat atgaataaca tggtgtgctt cttaaaatag ccataaaggg 1921 gagggactca tcatttccat ttacccttct tttctgacta tttttcagaa tctctcttct 1981 tttcaagttg ggtgatatgt tggtagattc taatggcttt attgcagcga ttaataacag 2041 gcaaaaggaa gcagggttgg tttcccttct ttttgttctt catctaagcc ttctggtttt 2101 atgggtcaga gttccgactg ccatcttgga cttgtcagca aaaaaaaaaa aaaaaa (2) INFORMATION FOR SEQ ID NO:1l: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 949 base pairs (B) TYPE: nucleic acid *(C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:1l: 1 agaagctttt gctcctggga ttaggttgat gggcctctaa tgtcaccagt gaaatgggat 61 attagatatt ttccagctag gatacgacag ctcccaataa aaccaaatta ctaagccttt 121 tctgcaagca aggagccgtc tggaacataa ggactttaac cttgggtagg agacaggcaa 181 gcagaagtct tcaattgtgt cacaattttc actgaggact caagtgacct aagaaagtaa 241 ttgtgattgt cagagccttg ttcttccttt tctttctcca gccgcacgct tcacctactc 301 aggagagtgc ctacgcaatc tgacttgaca gcttctagaa agaaattaga gcaacagggg WO 00/09525 PCT/US99/17712 EPI-109 1096 361 tctcagcagg gtggtcttgg gccaaacact gaaagcaggc aggcttaccc tttcctcttc 421 tgcccccttc aactttttcc tgatgttctt acccacatcc ctcaccacac cacacccttt 481 cattcatcct tgtcccagac ttattaagta tatacagata agcaatccag ggaacttgca 541 ttcattagga gaaacccaga aattcaaaag caataatgat ctaatcccag aggagtagaa 601 aacaggaagt gggcagctgc cagctttctt gctttgctgg agtattctgg aatttgatgg 661 gttgagggtt ctggacacaa tgccccaagc cccttccttg ttgtgctggg ttcctatttc 721 tgctctcggc actgacttag cagctgctca agagctcact atgttggctt ggattacact 781 ggtctcaccc acatctccgg cagtttgtgg gcaaacctcc tgagcagcct tgggtgatga 841 aacctttcat ggtagcagga gaatgggact gtgaattctc aatcccctgt ccccacccct 901 tccttcctct ctcagggcct taaagtctag gaggaggaag cacagcagc (2) INFORMATION FOR SEQ ID NO:12: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 3734 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:12: 1 cttgctttgc tggagtattc tggtaatttg atgggttgag ggttctggac acaatgcccc 61 aagccccttc cttgttgtgc tgggttccta tttctgctct cggcactgac ttagcagctg 121 ctcaagagct cactatgttg gcttggatta cacggtctca cccacatctc cggcagtttg 181 tgggcaaacc tcctgagcag ccttgggtga tgaaaccttt catggtagca ggagaatggg 241 actgtgaatt ctcaatcccc tgtccccacc ccttccttcc tctctcaggg ccttaaagtc 301 taggaggagg aagcacagca gcaactgact gggcagcctt tcaggaaaga tgcagccact 361 cctgcttctg ctggcctttc tcctacccac tggggctgag gcaggtgagt gaccatcccc 421 accctcagag gcctgacctc atcccataga ttcttgagcc aaattgcctt ggtatatcct 481 aattctgtac tgttgagcaa gttatttgaa tttgtgtttc ctcatctata aaatgagaat 541 aatattaata ccgatcttgc agagttgcca tgagagttaa ataagttaga gtatttaaat 601 gtcttggaat tgcccgcaca ctataagtgc tataaaaaca tgctttgtgt aaataatttg 661 gcagcatgtg tcagacccta cctaggaggt aagaatacag caataacagt accatcagct 721 catgtctaga tttttaaaca ccagtcccac gtggtcttga attggactca gagggctctg 781 ggaagctcca tgaggataaa agtataaggg aacttcagga acaatcctgt acttacagca 841 aagcattctc ctcaatacct gaggctgaag ctggccttgc ctggaacaag ggttgttctc 901 cctcttttgg agaggaggag ggaggtgagg cctaggatgg ggaaaagggc tcctttcaag 961 acagcagtgt ttcctgtaga accctggagc cccctcccaa tctgctgccc catagactcc 1021 aagcctcagc accatctcct ccctctcctg caccctctct cctgccgtcc ccatcttcca 1081 gcctttctgg agccaccaat ctggtaccca cattgcaggt tcagcaagca tagagctaag 1141 tgccaaatgc ttccttccag gggagatcat cggaggccgg gagagcaggc cccactcccg 1201 cccctacatg gcgtatcttc agatccagag tccagcaggt cagagcagat gtggagggtt 1261 cctggtgcga gaagactttg tgctgacagc agctcattgc tggggaaggt gaggagctaa 1321 ggaacttcct ggccagccag gaacacagcc ctgcggagct cttcggtgga agagccatct 1381 gaaagaagag ttgtagcaat gaaagggtga aagaaagacc aagtgagtct ttgcgggagg 1441 gaacaggcca gtgtaaatga ggaggaaagg aggataagat caaaaagagc aagaggaaga 1501 gatggaagac acatattggg gctcaaaata taaactcagg ctatttatca acttaatctg 1561 gggaagtaaa cctgaaggca agtaccaccc tgtcatccct agctcagagc tgctgagaaa 1621 gaggatacag ctgagcccca gggccctccc atcccctcga ttctggttag ctgcagtctt 1681 gccctccccg tgctgtctgc ctaccctgca gagctggtgg accatagctc ctgcagccca 1741 gacctacctc ttgcttttgc agcaatataa atgtcaccct gggcgcccac aatatccaga 1801 gacgggaaaa cacccagcaa cacatcactg cgcgcagagc catccgccac cctcaatata 1861 atcagcggac catccagaat gacatcatgt tattgcaggt accacctacc tggccctctg 1921 gctccttcct agtgtgtccg gggacaatgg aggaggaagt gagggcaagg ctccggggtg 1981 gcggggaggg catgggatgt gtactgcacc agcqaccccc gagccttggc tggaggcccc 2041 agctgagcgg gaacgcctac attcttcctc cagctgagca gaagagtcag acggaatcga 2101 aacgtgaacc cagtggctct gcctagagcc caggagggac tgagacccgg gacgctgtgc 2161 actgtggccg gctggggcag ggtcagcatg aggaggggaa cagatacact ccgagaggtg 2221 cagctgagag tgcagaggga taggcagtgc ctccgcatct tcggttccta cgacccccga 2281 aggcagattt gtgtggggga ccggcgggaa cggaaggctg ccttcaaggt aaggcatggg 2341 cattggccaa cacaccccgg gagagagggg cccgtgcaga gccaggcagt gcgaacagat 2401 tccatcccca cagcctcagc ctggcagcca gaccagggtg ggctggggat tgttttcccc 2461 atcaacctgg tctctggggg aataggagga agacccacaa cacatacata ggcaacattc 2521 tcctggagaa gggagaggta ccttgactca gattgggctg gagacagtaa ttaaggcaga 2581 gctgaagtcc agcgaccgaa aagatccaga ggcttggctc ctgtacccca ccgatcttcc 2641 atctcacaca cacccagcaa ttgaaggggc ccacccaccc ctgccttccc tgagagcccg 2701 gagctcaggg aagcaggagc agggaggcct gtctcagtct cccttctcct ctctacctac 2761 agggggattc cggaggcccc ctgctgtgta acaatgtggc ccacggcatc gtctcctatg 2821 gaaagtcgtc aggggttcct ccagaagtct tcaccagggt ctcaagtttc ctgccctgga 2881 taaggacaac aatqagaagc ttcaaactgc tggatcagat ggagaccccc ctgtgactga 2941 ctcttcttct cggggacaca ggccagctcc acagtgttgc cagagcctta ataaacgtcc 3001 acagagtata aataaccaat tcctcatttg ttcattaaac gtcattcagt acttagtttg WO 00/09525 PCT/US99/17712 EPI-109 1097 3061 tttggattgc tacaacaaaa tagcacaaat tgggtggctt ataaataaca aatttatttc 3121 tcacaggtct agaggctaag aagtctaaga tcaagtcact agcagattca gtgtctaatt 3181 agggcccatt ttctggttca cagacaacca tcctctccct gtgtccacat atggcaaaag 3241 gggcaaggga attctctgat gtctctttta caagggacct agtctcattc aaagagctca 3301 gcttttacga cctaatcaca tcccaaaggc cccacctaat gccatcacga cattggggat 3361 taggtctggg aaacataggg aaagagtgtc tctacacaaa aattttaaaa ttagccaggc 3421 atggtggcat gtgtctatag tcccagctac ttgggaggct aaagtggaag gattagttga 3481 acccacgagg ttgaggcttc agtgaaccat gcactccagc ctgagcgaca gagcaagaca 3541 ccattccaag aaagaaaaaa aaaaagactg gcaggccaaa aagacagaac tgaaattcca 3601 aaaaaaaaga cctactttag tgtatgaaaa aggtggcatc tcaaatcact gggaaacaat 3661 ggaatttttg aataaatagc attagaacca acctagatag atatttggag gggatggaag 3721 gtataattgg atcc (2) INFORMATION FOR SEQ ID NO:13: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 4683 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:13: 1 agaagctttt gctcctggga ttaggttgat gggcctctaa tgtcaccagt gaaatgggat 61 attagatatt ttccagctag gatacgacag ctcccaataa aaccaaatta ctaagccttt 121 tctgcaagca aggagccgtc tggaacataa ggactttaac cttgggtagg agacaggcaa 181 gcagaagtct tcaattgtgt cacaattttc actgaggact caagtgacct aagaaagtaa 241 ttgtgattgt cagagccttg ttcttccttt tctttctcca gccgcacgct tcacctactc 301 aggagagtgc ctacgcaatc tgacttgaca gcttctagaa agaaattaga gcaacagggg 361 tctcagcagg gtggtcttgg gccaaacact gaaagcaggc aggcttaccc tttcctcttc 421 tgcccccttc aactttttcc tgatgttctt acccacatcc ctcaccacac cacacccttt 481 cattcatcct tgtcccagac ttattaagta tatacagata agcaatccag ggaacttgca 541 ttcattagga gaaacccaga aattcaaaag caataatgat ctaatcccag aggagtagaa 601 aacaggaagt gggcagctgc cagctttctt gctttgctgg agtattctgg aatttgatgg 661 gttgagggtt ctggacacaa tgccccaagc cccttccttg ttgtgctggg ttcctatttc 721 tgctctcggc actgacttag cagctgctca agagctcact atgttggctt ggattacact 781 ggtctcaccc acatctccgg cagtttgtgg gcaaacctcc tgagcagcct tgggtgatga 841 aacctttcat ggtagcagga gaatgggact gtgaattctc aatcccctgt ccccacccct 901 tccttcctct ctcagggcct taaagtctag gaggaggaag cacagcagc 1 cttgctttgc tggagtattc tggtaatttg atgggttgag ggttctggac acaatgcccc 61 aagccccttc cttgttgtgc tgggttccta tttctgctct cggcactgac ttagcagctg 121 ctcaagagct cactatgttg gcttggatta cacggtctca cccacatctc cggcagtttg 181 tgggcaaacc tcctgagcag ccttgggtga tgaaaccttt catggtagca ggagaatggg 241 actgtgaatt ctcaatcccc tgtccccacc ccttccttcc tctctcaggg ccttaaagtc 301 taggaggagg aagcacagca gcaactgact gggcagcctt tcaggaaaga tgcagccact 361 cctgcttctg ctggcctttc tcctacccac tggggctgag gcaggtgagt gaccatcccc 421 accctcagag gcctgacctc atcccataga ttcttgagcc aaattgcctt ggtatatcct 481 aattctgtac tgttgagcaa gttatttgaa tttgtgtttc ctcatctata aaatgagaat 541 aatattaata ccgatcttgc agagttgcca tgagagttaa ataagttaga gtatttaaat 601 gtcttggaat tgcccgcaca ctataagtgc tataaaaaca tgctttgtgt aaataatttg 661 gcagcatgtg tcagacccta cctaggaggt aagaatacag caataacagt accatcagct 721 catgtctaga tttttaaaca ccagtcccac gtggtcttga attggactca gagggctctg 781 ggaagctcca tgaggataaa agtataaggg aacttcagga acaatcctgt acttacagca 841 aagcattctc ctcaatacct gaggctgaag ctggccttgc ctggaacaag ggttgttctc 901 cctcttttgg agaggaggag ggaggtgagg cctaggatgg ggaaaagggc tcctttcaag 961 acagcagtgt ttcctgtaga accctggagc cccctcccaa tctgctgccc catagactcc 1021 aagcctcagc accatctcct ccctctcctg caccctctct cctgccgtcc ccatcttcca 1081 gcctttctgg agccaccaat ctggtaccca cattgcaggt tcagcaagca tagagctaag 1141 tgccaaatgc ttccttccag gggagatcat cggaggccgg gagagcaggc cccactcccg 1201 cccctacatg gcgtatcttc agatccagag tccagcaggt cagagcagat gtggagggtt 1261 cctggtgcga gaagactttg tgctgacagc agctcattgc tggggaaggt gaggagctaa 1321 ggaacttcct ggccagccag gaacacagcc ctgcggagct cttcggtgga agagccatct 1381 gaaagaagag ttgtagcaat gaaagggtga aagaaagacc aagtgagtct ttgcgggagg 1441 gaacaggcca gtgtaaatga ggaggaaagg aggataagat caaaaagagc aagaggaaga 1501 gatggaagac acatattggg gctcaaaata taaactcagg ctatttatca acttaatctg 1561 gggaagtaaa cctgaaggca agtaccaccc tgtcatccct agctcagagc tgctgagaaa 1621 gaggatacag ctgagcccca gggccctccc atcccctcga ttctggttag ctgcagtctt 1681 gccctccccg tgctgtctgc ctaccctgca gagctggtgg accatagctc ctgcagccca 1741 gacctacctc ttgcttttgc agcaatataa atgtcaccct gggcgcccac aatatccaga 1801 gacgggaaaa cacccagcaa cacatcactg cgcgcagagc catccgccac cctcaatata 1861 atcagcggac catccagaat gacatcatgt tattgcaggt accacctacc tggccctctg 1921 gctccttcct agtgtgtccg gggacaatgg aggaggaagt gagggcaagg ctccggggtg WO 00/09525 PCT/US99/17712 EPI-109 1098 1981 gcggggaggg catgggatgt gtactgcacc agcgaccccc gagccttggc tggaggcccc 2041 agctgagcgg gaacgcctac attcttcctc cagctgagca gaagagtcag acggaatcga 2101 aacgtgaacc cagtggctct gcctagagcc caggagggac tgagacccgg gacgctgtgc 2161 actgtggccg gctggggcag ggtcagcatg aggaggggaa cagatacact ccgagaggtg 2221 cagctgagag tgcagaggga taggcagtgc ctccgcatct tcggttccta cgacccccga 2281 aggcagattt gtgtggggga ccggcgggaa cggaaggctg ccttcaaggt aaggcatggg 2341 cattggccaa cacaccccgg gagagagggg cccgtgcaga gccaggcagt gcgaacagat 2401 tccatcccca cagcctcaac ctggcagcca gaccagggtg ggctggggat tgttttcccc 2461 atcaacctgg tctctggggg aataggagga agacccacaa cacatacata ggcaacattc 2521 tcctggagaa gggagaggta ccttgactca gattgggctg gagacagtaa ttaaggcaga 2581 gctgaagtcc agcgaccgaa aagatccaga ggcttggctc ctgtacccca ccgatcttcc 2641 atctcacaca cacccagcaa ttgaaggggc ccacccaccc ctgccttccc tgagagcccg 2701 gagctcaggg aagcaggagc agggaggcct gtctcagtct cccttctcct ctctacctac 2761 agggggattc cggaggcccc ctgctgtgta acaatgtggc ccacggcatc gtctcctatg 2821 gaaagtcgtc aggggttcct ccagaagtct tcaccagggt ctcaagtttc ctgccctgga 2881 taaggacaac aatgagaagc ttcaaactgc tggatcagat ggagaccccc ctgtgactga 2941 ctcttcttct cggggacaca ggccagctcc acagtgttgc cagagcctta ataaacgtcc 3001 acagagtata aataaccaat tcctcatttg ttcattaaac gtcattcagt acttagtttg 3061 tttggattgc tacaacaaaa tagcacaaat tgggtggctt ataaataaca aatttatttc 3121 tcacaggtct agaggctaag aagtctaaga tcaagtcact agcagattca gtgtctaatt 3181 agggcccatt ttctggttca cagacaacca tcctctccct gtgtccacat atggcaaaag 3241 gggcaaggga attctctgat gtctctttta caagggacct agtctcattc aaagagctca 3301 gcttttacga cctaatcaca tcccaaaggc cccacctaat gccatcacga cattggggat 3361 taggtctggg aaacataggg aaagagtgtc tctacacaaa aattttaaaa ttagccaggc 3421 atggtggcat gtgtctatag tcccagctac ttgggaggct aaagtggaag gattagttga 3481 acccacgagg ttgaggcttc agtgaaccat gcactccagc ctgagcgaca gagcaagaca 3541 ccattccaag aaagaaaaaa aaaaagactg gcaggccaaa aagacagaac tgaaattcca 3601 aaaaaaaaga cctactttag tgtatgaaaa aggtggcatc tcaaatcact gggaaacaat 3661 ggaatttttg aataaatagc attagaacca acctagatag atatttggag gggatggaag 3721 gtataattgg atcc (2) INFORMATION FOR SEQ ID NO:14: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 2156 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:14: 1 ggcacgagcc cagaaacaaa gacttcacgg acaaagtccc ttggaaccag agagaagccg 61 ggatggaaac tccaaacacc acagaggact atgacacgac cacagagttt gactatgggg 121 atgcaactcc gtgccagaag gtgaacgaga gggcctttgg ggcccaactg ctgccccctc 181 tgtactcctt ggtatttgtc attggcctgg ttggaaacat cctggtggtc ctggtccttg 241 tgcaatacaa gaggctaaaa aacatgacca gcatctacct cctgaacctg gccatttctg 301 acctgctctt cctgttcacg cttcccttct ggatcgacta caagttgaag gatgactggg 361 tttttggtga tgccatqtgt aagatcctct ctgggtttta ttacacaggc ttgtacagcg 421 agatcttttt catcatcctg ctgacgattg acaggtacct ggccatcgtc cacgccgtgt 481 ttgccttgcg ggcacggacc gtcacttttg gtgtcatcac cagcatcatc atttgggccc 541 tggccatctt ggcttccatg ccaggcttat acttttccaa gacccaatgg gaattcactc 601 accacacctg cagccttcac tttcctcacg aaagcctacg agagtggaag ctgtttcagg 661 ctctgaaact gaacctcttt gggctggtat tgcctttgtt ggtcatgatc atctgctaca 721 cagggattat aaagattctg ctaagacgac caaatgagaa gaaatccaaa gctgtccgtt 781 tgatttttgt catcatgatc atcttttttc tcttttggac cccctacaat ttgactatac 841 ttatttctgt tttccaagac ttcctgttca cccatgagtg tgagcagagc agacatttgg 901 acctggctgt gcaagtgacg gaggtgatcg cctacacgca ctgctgtgtc aacccagtga 961 tctacgcctt cgttggtgag aggttccgga agtacctgcg gcagttgttc cacaggcgtg 1021 tggctgtgca cctggttaaa tggctcccct tcctctccgt ggacaggctg gagagggtca 1081 gctccacatc tccctccaca ggggagcatg aactctctgc tgggttctga ctcagaccat 1141 aggaggccaa cccaaaataa gcaggcgtga cctgccaggc acactgagcc agcagcctgg 1201 ctctcccagc caggttctga ctcttggcac agcatggagt cacagccact tgggatagag 1261 agggaatgta atggtggcct ggggcttctg aggcttctgg ggcttcagtc ttttccatga 1321 acttctcccc tggtagaaag aagatgaatg agcaaaacca aatattccag agactgggac 1381 taagtgtacc agagaagggc ttggactcaa gcaagatttc agatttgtga ccattagcat 1441 ttgtcaacaa agtcacccac ttcccactat tgcttgcaca aaccaattaa acccagtagt 1501 ggtgactgtg ggctccattc aaagtgagct cctaagccat gggagacact gatgtatgag 1561 gaatttctgt tcttccatca cctccccccc cccgccaccc tcccactgcc aagaacttgg 1621 aaatagtgat ttccacagtg actccactct gagtcccaga gccaatcagt agccagcatc 1681 tgcctcccct tcactcccac cgcaggattt gggctcttgg aatcctgggg aacatagaac 1741 tcatgacgga agagttgaga cctaacgaga aatagaaatg ggggaactac tgctggcagt WO 00/09525 PCT/US99/17712 EPI-109 1099 1801 ggaactaaga aagcccttag gaagaatttt tatatccact aaaatcaaac aattcaggga 1861 gtgggctaag cacgggccat atgaataaca tggtgtgctt cttaaaatag ccataaaggg 1921 gagggactca tcatttccat ttacccttct tttctgacta tttttcagaa tctctcttct 1981 tttcaagttg ggtgatatgt tggtagattc taatggcttt attgcagcga ttaataacag 2041 gcaaaaggaa gcagggttgg tttcccttct ttttgttctt catctaagcc ttctggtttt 2101 atgggtcaga gttccgactg ccatcttgga cttgtcagca aaaaaaaaaa aaaaaa (2) INFORMATION FOR SEQ ID NO:15: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 2955 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:15: 1 gagagccccc cccccgagac tgaaagtttt ggagattcag gggtcggggg aaagggttca 61 ggaaatggta attgagtttc caagggatag tgttacaagt ggtatgggag gccccctatt 121 tctgatagta atagagaata ttttctttgt tcattatgat agaacccgtg ggataaagag 181 ggaaaataaa tgttgggagt cccccagggg agaggagaga atccaacagg gtgatttgct 241 gatatttgta cgaggaggga aaqaattttt caaagacaaa gttggagtga ggagtttttg 301 tagagggaac caggtggggt acaaagagag agacacactg agccggtggg aagggaagaa 361 ttaagagggg tgttccccca cactgtatat taagaaagaa aaacaatggg gacaggacgg 421 cagaagttag agtttcttaa ccaggatgag agggggattt cacggtaact aatgagtgat 481 ttcagacctt attccactat cccagggcaa tcagatatta atcatgtaca agttgaaatc 541 atgcgtgtcc tttgaggtaa gacttacata atcctattta gcataacagg cccccagatc 601 cagaaagggg agggttccgc ccctatcact gaaggggatc agggatatga aagtggctca 661 tggttgacca tcacgtttaa caggaatggg caatcaggag gggtaggtcc aattgtgacc 721 aacagaccaa acttccatta atgcttgcgg ttcttgtggc aaagccagtc tgtgaggttt 781 gatggggatg gacttggtga gcagagagca gggggacaac gaatcccaga agctgagggg 841 aatggggttc caaagagccg ctgctgcctc tgggagcacc catgtcagtt agtttttccg 901 tacgggactc agggttccag attattcgtt tttaaatcct tccattcaca atctttaaga 961 agaagaaaaa aaagaagtct gccgctgacc acaagagctc tatgccctgc ccccatccca 1021 catacacaca tcccacactt caattgctcc aaacattctg ggaacatctc actgccaccc 1081 acctcaccca actcagcttc acctgccccc aattccctta aggctgagct cccagggcca 1141 agactcaaga ggctcagagt gagcagagaa aatcctcgca gttaacttgg cttccaggaa 1201 gtggccactg gtgggcgttg tggccattca tgagcaccaa accacacaaa aagaactttg 1261 tccctttctt gtcattttga aagactgtga aactggagcc aattctccat catcacacag 1321 gaagctgagt acttcctact tggtcaggat cttgaaactt gaattcataa aacccagaaa 1381 gccccagaaa caaagacttc acggacaaag tcccttggaa ccagagtaag tgtcacttgt 1441 cttttctgtc ttatctgtta ctgtggaggg cagtgttgtt caaagacatg catgcagcta 1501 ggggctcctc aaaggtaggg ggaattcttt gagtaggctg ggcaaatgtc taagtagccc 1561 atggatgcat ctccaaggca attaatactg tagcaatact gagaatggtg gatttataaa 1621 gctgggtgct cagatgaaat ataggctttt ttgctaaaaa ggaagcttac ttgaaggatt 1681 ggcttttggt tactgattaa gaaagtcagt cagtactaag ggacaaaagg tgttttctgt 1741 ggaaacctat tcaataagaa attacttggc ggggcgcagt ggctcacggc tgtaatccca 1801 gcactttggg agaccgaggc aggtggatca tgaggtcaag agatggagac aatcctggcc 1861 atatggtgaa accctgtctc tactaaaaat aaaaattagc cgggcaggtg gccgcagcct 1921 gttagtccca gctactcaag aggctgaggc aggagaatca ctcgaatccg ggaggtggag 1981 gttgcagtga gctgagattg caccacaaca ctccagcctg gcgacagagc aagagtctgt 2041 ctgaaaaaaa aaaattgctt gccaaattcc cccaagtaaa ggaaaaccaa acatggtgta 2101 tgaagaaatt atagcaagag ggaaatatta gctagaaaaa tcttggcaga tgcaaggatg 2161 atttgatact gaacctatct cttaagaaga ctagaaccaa ggatcctcaa aattggcact 2221 gctatctttg gaagagaggt aggctttcac tcacccaaag gcaaggagct ggccaggtga 2281 tcttgggggg catctgttct gctctactaa caaagacaca ggtcaggatt ttgttctgaa 2341 gatagagggg catggtggct ccgtataggt atctacttca taggtggcct tggtgggtcc 2401 cagatttcaa agaagagatg gaaactccca aaagtttgca caacctggca ccaggctatg 2461 tgccactcac tgatccttta gtccccgcac cgagcagtgg gacagtgctg gactgttcag 2521 aatgtggggc ctgggcagtg atgtgctggt aaatgttcaa caactgactc ttctgaagaa 2581 aagatccctg ctttataaca tttgttgatt ttcatggtat aaatgccccc actgtggtca 2641 gtttcaagct accaacatgc tgaatgtgga gtggggaaga gatgcacgca attggcattt 2701 ataaaccagt ataagccagc cagcgcacca taggcctggg tgtctttcac catcacagac 2761 tgctctactc tgctcagaga ctcaccaact cccaggctgg aagacactag cagtggaagg 2821 tccaggatcc agggctatac tgaccactgt gccagtggcc ttgaggcaga ctctgcagta 2881 gacaacancc agggctggcc nattagatga caacatgncc ttggtccctc tcgggcccaa 2941 cccagacacc tcctg (2) INFORMATION FOR SEQ ID NO:16: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1495 base pairs (B) TYPE: nucleic acid WO 00/09525 PCT/US99/17712 EPI-109 1100 (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:16: 1 atggaaactc caaacaccac agaggactat gacacgacca cagagtttga ctatggggat 61 gcaactccgt gccagaaggt gaacgagagg gcctttgggg cccaactgct gccccctctg 121 tactccttgg tatttgtcat tggcctggtt ggaaacatcc tggtggtcct ggtccttgtg 181 caatacaaga ggctaaaaaa catgaccagc atctacctcc tgaacctggc catttctgac 241 ctgctcttcc tgttcacgct tcccttctgg atcgactaca agttgaagga tgactgggtt 301 tttggtgatg ccatgtgtaa gatcctctc gggttttatt acacaggctt gtacagcgag 361 atctccttca tcatcctgct gacgattgac aggtacctgg ccatcgtcca cgccgtgttt 421 gccttgcggg cacggaccgt cacttttggt gtcatcacca gcatcatcat ttgggccctg 481 gccatcttgg cttccatgcc aggcttatac ttttccaaga cccaatggga attcactcac 541 cacacctgca gccttcactt tcctcacgaa agcctacgag agtggaagct gtttcaggct 601 ctgaaactga acctctttgg gctggtattg cctttgttgg tcatgatcat ctgctacaca 661 gggattataa agattctgct aagacgacca aatgagaaga aatccaaagc tgtccgtttg 721 atttttgtca tcatgatcat cttttttctc ttttggaccc cctacaattt gactatactt 781 atttctgttt tccaagactt cctgttcacc catgagtgtg agcagagcag acatttggac 841 ctggctgtgc aagtgacgga ggtgatcgcc tacacgcact gctgtgtcaa cccagtgatc 901 tacgccttcg ttggtgagag gttccggaag tacctgcggc agttgttcca caggcgtgtg 961 gctgtgcacc tggttaaatg gctccccttc ctctccgtgg acaggctgga gagggtcagc 1021 tccacatctc cctccacagg ggagcatgaa ctctctgctg ggttctgact cagaccatag 1081 gaggccaacc caaaataagc aggcgtgacc tgccaggcac actgaccagc agcctggctc 1141 tcccagccag gttctgactc ttggcacagc atggagtccg cctcttggat agagaggaat 1201 gtaatggtgg cctggggctt ctgaggcttc tgggcttgag tcttttccat gaacttctcc 1261 cctggtagaa aagaagatga atgagcaaaa ccaaatattc cagagactgg gactaagtgt 1321 accagagaag ggcttggact caagcaagat ttcagatttg tgaccattag catttgtcaa 1381 caaagtcacc cacttcccac tattgcttgc acaaaccaat taaacccagt agtggtgact 1441 gtgggctcca ttcaaagtga gctcctaagc catgggagac actgatgtat gagga (2) INFORMATION FOR SEQ ID NO:17: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 6606 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (0) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:17: 1ggcacgagcc cagaaacaaa gacttcacgg acaaagtccc ttggaaccag agagaagccg 61 ggacggaaac tccaaacacc acagaggact atgacacgac cacagagttt gactatgggg 121 atgcaactcc gtgccagaag gtgaacgaga gggcctttgg ggcccaactg ctgccccctc 181 tgtactcctt ggtatttgtc attggcctgg ttggaaacat cctggtggtc ctggtccttg 241 tgcaatacaa gaggctaaaa aacatgacca gcatctacct cctgaacctg gccatttctg 301 acctgctctt cctgttcacg cttcccttct ggatcgacta caagttgaag gatgactggg 361 tttttggtga tgccatgtgt aagatcctct ctgggtttta ttacacaggc ttgtacagcg 421 agatcttttt catcatcctg ctgacgacrg acaggtacct ggccatcgtc cacgccgtgt 481 ttgccttgcg ggcacggacc gtcacttttg gtgtcatcac cagcatcatc atttgggccc 541 tggccatctt ggcttccatg ccaggcttat acttttccaa gacccaatgg gaattcactc 601 accacacctg cagccttcac tttcctcacg aaagcctacg agagtggaag ctgtttcagg 661 ctctgaaact gaacctcttt gggctggtat tgcctttgtt ggtcatgatc atctgctaca 721 cagggattat aaagattctg ctaagacgac caaatgagaa gaaatccaaa gctgtccgtt 781 tgatttttgt catcatgatc atcttttttc tcttttggac cccctacaat ttgactatac 841 ttatttctgt tttccaagac ttcctgttca cccatgagtg tgagcagagc agacatttgg 901 acctggctgt gcaagtgacg gaggtgatcg cctacacgca ctgctgtgtc aacccagtga 961 tctacgcctt cgttggtgag aggttccgga agtacctgcg gcagttgttc cacaggcgtg 1021 tggctgtgca cctggttaaa tggctcccct tcctctccgt ggacaggctg gagagggtca 1081 gctccacatc tccctccaca ggggagcatg aactctctgc tgggttctga ctcagaccat 1141 aggaggccaa cccaaaataa gcaggcgtga cctgccaggc acactgagcc agcagcctgg 1201 ctctcccagc caggttctga ctcttggcac agcatggagt cacagccact tgggatagag 1261 agggaatgta atggtggcct ggggcttctg aggcttctgg ggcttcagtc ttttccatga 1321 acttctcccc tggtagaaag aagatgaatg agcaaaacca aatattccag agactgggac 1381 taagtgtacc agagaagggc ttggactcaa gcaagatttc agatttgtga ccattagcat 1441 ttgtcaacaa agtcacccac ttcccactat tgcttgcaca aaccaattaa acccagtagt 1501 ggtgactgtg ggctccattc aaagtgagct cctaagccat gggagacact gatgtatgag 1561 gaatttctgt tcttccatca cctccccccc cccgccaccc tcccactgcc aagaacttgg 1621 aaatagtgat ttccacagtg actccactct gagtcccaga gccaatcagt agccagcatc 1681 tgcctcccct tcactcccac cgcaggattt gggctcttgg aatcctgggg aacatagaac 1741 tcatgacgga agagttgaga cctaacgaga aatagaaatg ggggaactac tgctggcagt 1801 ggaactaaga aagcccttag gaagaatttt tatatccact aaaatcaaac aattcaggga 1861 gtgggctaag cacgggccat atgaataaca tggtgtgctt cttaaaatag ccataaaggg 1921 gagggactca tcatttccat ttacccttct tttctgacta tttttcagaa tctctcttct WO 00/09525 PCT/US99/17712 EPI-109 1101 1981 tttcaagttg ggtgatatgt tggtagattc taatggcttt attgcagcga ttaataacag 2041 gcaaaaggaa gcagggttgg tttcccttct ttttgttctt catctaagcc ttctggtttt 2101 atgggtcaga gttccgactg ccatcttgga cttgtcagca aaaaaaaaaa aaaaaa 1 gagagccccc cccccgagac tgaaagtttt ggagattcag gggtcggggg aaagggttca 61 ggaaatggta attgagtttc caagggatag tgttacaagt ggtatgggag gccccctatt 121 tctgatagta atagagaata ttttctttgt tcattatgat agaacccgtg ggataaagag 181 ggaaaataaa tgttgggagt cccccagggg agaggagaga atccaacagg gtgatttgct 241 gatatttgta cgaggaggga aagaattttt caaagacaaa gttggagtga ggagtttttg 301 tagagggaac caggtggggt acaaagagag agacacactg agccggtggg aagggaagaa 361 ttaagagggg tgttccccca cactgtatat taagaaagaa aaacaatggg gacaggacgg 421 cagaagttag agtttcttaa ccaggatgag agggggattt cacggtaact aatgagtgat 481 ttcagacctt attccactat cccagggcaa tcagatatta atcatgtaca agttgaaatc 541 atgcgtgtcc tttgaggtaa gacttacata atcctattta gcataacagg cccccagatc 601 cagaaagggg agggttccgc ccctatcact gaaggggatc agggatatga aagtggctca 661 tggttgacca tcacgtttaa caggaatggg caatcaggag gggtaggtcc aattgtgacc 721 aacagaccaa acttccatta atgcttgcgg ttcttgtggc aaagccagtc tgtgaggttt 781 gatggggatg gacttggtga gcagagagca gggggacaac gaatcccaga agctgagggg 841 aatggggttc caaagagccg ctgctgcctc tgggagcacc catgtcagtt agtttttccg 901 tacgggactc agggttccag attattcgtt tttaaatcct tccattcaca atctttaaga 961 agaagaaaaa aaagaagtct gccgctgacc acaagagctc tatgccctgc ccccatccca 1021 catacacaca tcccacactt caattgctcc aaacattctg ggaacatctc actgccaccc 1081 acctcaccca actcagcttc acctgccccc aattccctta aggctgagct cccagggcca 1141 agactcaaga ggctcagagt gagcagagaa aatcctcgca gttaacttgg cttccaggaa 1201 gtggccactg gtgggcgttg tggccattca tgagcaccaa accacacaaa aagaactttg 1261 tccctttctt gtcattttga aagactgtga aactggagcc aattctccat catcacacag 1321 gaagctgagt acttcctact tggtcaggat cttgaaactt gaattcataa aacccagaaa 1381 gccccagaaa caaagacttc acggacaaag tcccttggaa ccagagtaag tgtcacttgt 1441 cttttctgtc ttatctgtta ctgtggaggg cagtgttgtt caaagacatg catgcagcta 1501 ggggctcctc aaaggtaggg ggaattcttt gagtaggctg ggcaaatgtc taagtagccc 1561 atggatgcat ctccaaggca attaatactg tagcaatact gagaatggtg gatttataaa 1621 gctgggtgct cagatgaaat ataggctttt ttgctaaaaa ggaagcttac ttgaaggatt 1681 ggcttttggt tactgattaa gaaagtcagt cagtactaag ggacaaaagg tgttttctgt 1741 ggaaacctat tcaataagaa attacttggc ggggcgcagt ggctcacggc tgtaatccca 1801 gcactttggg agaccgaggc aggtggatca tgaggtcaag agatggagac aatcctggcc 1861 atatggtgaa accctgtctc tactaaaaat aaaaattagc cgggcaggtg gccgcagcct 1921 gttagtccca gctactcaag aggctgaggc aggagaatca ctcgaatccg ggaggtggag 1981 gttgcagtga gctgagattg caccacaaca ctccagcctg gcgacagagc aagagtctgt 2041 ctgaaaaaaa aaaattgctt gccaaattcc cccaagtaaa ggaaaaccaa acatggtgta 2101 tgaagaaatt atagcaagag ggaaatatta gctagaaaaa tcttggcaga tgcaaggatg 2161 atttgatact gaacctatct cttaagaaga ctagaaccaa ggatcctcaa aattggcact 2221 gctatctttg gaagagaggt aggctttcac tcacccaaag gcaaggagct ggccaggtga 2281 tcttgggggg catctgttct gctctactaa caaagacaca ggtcaggatt ttgttctgaa 2341 gatagagggg catggtggct ccgtataggt atctacttca taggtggcct tggtgggtcc 2401 cagatttcaa agaagagatg gaaactccca aaagtttgca caacctggca ccaggctatg 2461 tgccactcac tgatccttta gtccccgcac cgagcagtgg gacagtgctg gactgttcag 2521 aatgtggggc ctgggcagtg atgtgctggt aaatgttcaa caactgactc ttctgaagaa 2581 aagatccctg ctttataaca tttgttgatt ttcatggtat aaatgccccc actgtggtca 2641 gtttcaagct accaacatgc tgaatgtgga gtggggaaga gatgcacgca attggcattt 2701 ataaaccagt ataagccagc cagcgcacca taggcctggg tgtctttcac catcacagac 2761 tgctctactc tgctcagaga ctcaccaact cccaggctgg aagacactag cagtggaagg 2821 tccaggatcc agggctatac tgaccactgt gccagtggcc ttgaggcaga ctctgcagta 2881 gacaacancc agggctggcc nattagatga caacatgncc ttggtccctc tcgggcccaa 2941 cccagacacc tcctg 1 atggaaactc caaacaccac agaggactat gacacgacca cagagtttga ctatggggat 61 gcaactccgt gccagaaggt gaacgagagg gcctttgggg cccaactgct gccccctctg 121 tactccttgg tatttgtcat tggcctggtt ggaaacatcc tggtggtcct ggtccttgtg 181 caatacaaga ggctaaaaaa catgaccagc atctacctcc tgaacctggc catttctgac 241 ctgctcttcc tgttcacgct tcccttctgg atgactaca agttgaagga tgactgggtt 301 tttggtgatg ccatgtgtaa gatcctctct gggttttatt acacaggctt gtacagcgag 361 atctttttca tcatcctgct gacgattgac aggtacctgg ccatcgtcca cgccgtgttt 421 gccttgcggg cacggaccgt cacttttggt gtcatcacca gcatcatcat ttgggccctg 481 gccatcttgg cttccatgcc aggcttatac ttttccaaga cccaatggga attcactcac 541 cacacctgca gccttcactt tcctcacgaa agcctacgag agtggaagct gtttcaggct 601 ctgaaactga acctctttgg gctggtattg cctttgttgg tcatgatcat ctgctacaca 661 gggattataa agattctgct aagacgacca aatgagaaga aatccaaagc tgtccgtttg 721 atttttgtca tcatgatcat cttttttc c ttttggaccc cctacaattt gactatactt 781 atttctgttt tccaagactt cctgttcacc catgagtgtg agcagagcag acatttggac 841 ctggctgtgc aagtgacgga ggtgatcgcc tacacgcact gctgtgtcaa cccagtgatc WO 00/09525 PCT/US99/17712 EPI-109 1102 901 tacgccttcg ttggtgagag gttccggaag tacctgcggc agttgttcca caggcgtgtg 961 gctgtgcacc tggttaaatg gctccccttc ctctccgtgg acaggctgga gagggtcagc 1021 tccacatctc cctccacagg ggagcatgaa ctctctgctg ggttctgact cagaccatag 1081 gaggccaacc caaaataagc aggcgtgacc tgccaggcac actgaccagc agcctggctc 1141 tcccagccag gttctgactc ttggcacagc atggagtccg cctcttggat agagaggaat 1201 gtaatggtgg cctggggctt ctgaggcttc tgggcttgag tcttttccat gaacttctcc 1261 cctggtagaa aagaagatga atgagcaaaa ccaaatattc cagagactgg gactaagtgt 1321 accagagaag ggcttggact caagcaagat ttcagatttg tgaccattag catttgtcaa 1381 caaagtcacc cacttcccac tattgcttgc acaaaccaat taaacccagt agtggtgact 1441 gtgggctcca ttcaaagtga gctcctaagc catgggagac actgatgtat gagga (2) INFORMATION FOR SEQ ID NO:18: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1068 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:18: 1 atgacaacct cactagatac agttgagacc tttggtacca catcctacta tgatgacgtg 61 ggcctgctct gtgaaaaagc tgataccaga gcactgatgg cccagtttgt gcccccgctg 121 tactccctgg tgttcactgt gggcctcttg ggcaatgtgg tggtggtgat gatcctcata 181 aaatacagga ggctccgaat tatgaccaac atctacctgc tcaacctggc catttcggac 241 ctgctcttcc tcgtcaccct tccattctgg atccactatg tcagggggca taactgggtt 301 tttggccatg gcatgtgtaa gctcctctca gggttttatc acacaggctt gtacagcgag 361 atctttttca taatcctgct gacaatcgac aggtacccgg ccattgtcca tgctgtgttt 421 gcccttcgag cccggactgt cacttttggt gtcatcacca gcatcgtcac ctggggcctg 481 gcagtgctag cagctcttcc tgaatttatc ttctatgaga ctgaagagtt gtttgaagag 541 actctttgca gtgctcttta cccagaggat acagtatata gctggaggca tttccacact 601 ctgagaatga ccatcttctg tctcgttctc cctctgctcg ttatggccat ctgctacaca 661 ggaatcatca aaacgctgct gaggtgcccc agtaaaaaaa agtacaaggc catccggctc 721 atttttgtca tcatggcggt gtttttcatt ttctggacac cctacaatgt ggctatcctt 781 ctctcttcct atcaatccat cttatttgga aatgactgtg agcggagcaa gcatctggac 841 ctggtcatgc tggtgacaga ggtgatcgcc tactcccact gctgcatgaa cccggtgatc 901 tacgcctttg ttggagagag gttccggaag tacctgcgcc acttcttcca caggcacttg 961 ctcatgcacc tgggcagata catcccattc cttcctagtg agaagctgga aagaaccagc 1021 tctgtctctc catccacagc agagccggaa ctctctattg tgttttag (2) INFORMATION FOR SEQ ID NO:19: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1201 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear )xi)SEQUENCE DESCRIPTION: SEQ ID NO:19: 1 tttttcttct tctatcacag ggagaagtga aatgacaacc tcactagata cagttgagac 61 ctttggtacc acatcctact atgatgacgt gggcctgctc tgtgaaaaag ctgataccag 121 agcactgatg gcccagtttg tgcccccgct gtactccctg gtgttcactg tgggcctctt 181 gggcaatgtg gtggtggtga tgatcctcat aaaatacagg aggctccgaa ttatgaccaa 241 catctacctg ctcaacctgg ccatttcgga cctgctcttc ctcgtcaccc ttccattctg 301 gatccactat gtcagggggc ataactgggt ttttggccat ggcatgtgta agctcctctc 361 agggttttat cacacaggct tgtacagcga gatctttttc ataatcctgc tgacaatcga 421 caggtacctg gccattgtcc atgctgtgtt tgcccttcga gcccggactg tcacttttgg 481 tgtcatcacc agcatcgtca cctggggcct ggcagtgcta gcagctcttc ctgaatttat 541 cttctatgag actgaagagt tgtttgaaga gactctttgc agtgctcttt acccagagga 601 tacagtatat agctggaggc atttccacac tctgagaatg accatcttct gtctcgttct 661 ccctctgctc gttatggcca tctgctacac aggaatcatc aaaacgctgc tgaggtgccc 721 cagtaaaaaa aagcacaagg ccatccggct catttttgtc atcatggcgg tgtttttcat 781 tttctggaca ccctacaatg tggctatcct tctctcttcc tatcaatcca tcttatttgg 841 aaatgactgt gagcggagca agcatctgga cctggtcatg ctggtgacag aggtgatcgc 901 ctactcccac tgctgcatga acccggtgat ctacgccttt gttggagaga ggttccggaa 961 gtacctgcgc cacttcttcc acaggcactt gctcatgcac ctgggcagat acatcccatt 1021 ccttcctagt gagaagctgg aaagaaccag ctctgtctct ccatccacag cagagccgga 1081 actctctatt gtgttttagg tcagatgcag aaaattgcct aaagaggaag gaccaaggag 1141 atgaagcaaa cacattaagc cttccacact cacctctaaa acagtccttc aaacttccag 1201 t (2) INFORMATION FOR SEQ ID NO:20: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1699 base pairs WO 00/09525 PCT/US99/17712 EPI-109 1103 (B) TYPE: nucieic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:20: 1 aatccttttc ctggcacctc tgatatcctt ttgaaattca tgttaaagaa tccctaggct 61 gctatcacat gtggcatctt tgttgagtac atgaataaat caactggtgt gttttacgga 121 ggatgattat gcttcaccgt gggattgtat ttttcttctt ctatcacagg gagaagtgaa 181 atgacaacct cactagarac agttgagacc tttggtacca catcctacta tgatgacgtg 241 ggcctgctct gtgaaaaagc tgataccaga gcactgatgg cccagtttgt gcccccgctg 301 tactccctgg tgttcactgt gggcctcttg ggcaatgtgg tggtggtgat gatcctcata 361 aaatacagga ggctccgaat tatgaccaac atctacctgc tcaacctggc catttcggac 421 ctgctcttco tcgtcaccct tccattctgg atccactatg tcagggggca taactgggtt 481 tttggccatg gcatgtgtaa gctcctctca gggttttatc acacaggctt gtacagcgag 541 atctttttca taatcctgct gacaatcgac aggtacctgg ccattgtcca tgctgtgttt 601 gcccttcgag cccggactgt cacttttggt gtcatcacca gcatcgtcac ctggggcctg 661 gcagtgctag cagctcttcc tgaatttatc ttctatgaga ctgaagagtt gtttgaagag 721 actctttgca gtgctcttta cccagaggat acagtatata gctggaggca tttccacact 781 ctgagaatga ccatcttctg tctcgttctc cctctgctcg ttatggccat ctgctacaca 841 ggaatcatca aaacgctgct gaggtgcccc agtaaaaaaa agtacaaggc catccggctc 901 atttttgtca tcatggcggt gtttttcatt ttctggacac cctacaatgt ggctatcctt 961 ctctcttcct atcaatccat cttatttgga aatgactgtg agcggacgaa gcatctggac 1021 ctggtcatgc tggtgacaga gggatcgcc tactcccact gctgcatgaa cccggtgatc 1081 tacgccttta ttggagagag gttccggaag tacctgcgcc acttcttcca caggcacttg 1141 ctcatgcacc tgggcagata catcccattc cttcctagtg agaagctgga aagaaccagc 1201 tctgtctctc caccacagc agagccggaa ctctctattg tgttttaggt agatgcagaa 1261 aattgcctaa agaggaagga ccaaggagat naagcaaaca cattaagcct tccacactca 1321 cctctaaaac agtccttcaa accttccagt gcaacactga agctcttaag acactgaaat 1381 atacacacag cagtagcagt agatgcatgt accctaaggt cattaccaca ggccagggct 1441 gggcagcgta ctcatcatca acctaaaaag cagagctttg cttctctctc taaaatgagt 1501 tacctatatt ttaatgcacc tgaatgttag atagttacta tatgccgcta caaaaaggta 1561 aaacttttta tattttatac attaacttca gccagctatt atataaataa aacattttca 1621 cacaatacaa taagttaact attttatttt ctaatgtgcc tagttctttc cctgcttaat 1681 gaaaagctt (2) INFORMATION FOR SEQ ID NO:21: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 2968 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:21: 1 atgacaacct cactagatac agttgagacc tttggtacca catcctacta tgatgacgtg 61 ggcctgctct gtgaaaaagc tgataccaga gcactgatgg cccagtttgt gcccccgctg 121 tactccctgg tgttcactgt gggcctcttg ggcaatgtgg tggtggtgat gatcctcata 181 aaatacagga ggctccgaat tatgaccaac atctacctgc tcaacctggc catttcggac 241 ctgctcttcc tcgtcaccct tccattctgg atccactatg tcagggggca taactgggtt 301 tttggccatg gcatgtgtaa gctcctctca gggttttatc acacaggctt gtacagcgag 361 atctttttca taatcctgct gacaatcgac aggtacctgg ccattgtcca tgctgtgttt 421 gcccttcgag cccggactgt cacttttggt gtcatcacca gcatcgtcac ctggggcctg 481 gcagtgctag cagctcttcc tgaatttatc ttctatgaga ctgaagagtt gtttgaagag 541 actctttgca gtgctcttta cccagaggat acagtatata gctggaggca tttccacact 601 ctgagaatga ccatcttctg tctcgttctc cctctgctcg ttatggccat ctgctacaca 661 ggaatcatca aaacgctgct gaggtgcccc agtaaaaaaa agtacaaggc catccggctc 721 atttttgtca tcatggcggt gtttttcatt ttctggacac cctacaatgt ggctatcctt 781 ctctcttcct atcaatccat cttatttgga aatgactgtg agcggagcaa gcatctggac 841 ctggtcatgc tggtgacaga ggtgatcgcc tactcccact gctgcatgaa cccggtgatc 901 tacgcctttg ttggagagag gttccggaag tacctgcgcc acttcttcca caggcacttg 961 ctcatgcacc tgggcagata catcccattc cttcctagtg agaagctgga aagaaccagc 1021 tctgtctctc catccacagc agagccggaa ctctctattg tgttttag 1 tttttcttct tctatcacag ggagaagtga aatgacaacc tcactagata cagtgagac 61ctttggtacc acatcctact atgatgacgt gggcctgctc tgtgaaaaag ctgataccag 121 agcactgata gcccagtttg tgcccccgct gtactccctg gtgttcactg tgggcctctt 181 gggcaatgtg gtggtggtga tgatcctcat aaaatacagg aggctccgaa ttatgaccaa 241 catctacctg ctcaacctgg ccatttcgga cctgctcttc ctcgtcaccc ttccattctg 301 gatccactaa gtcagggggc ataactgggt ttttggccat ggcatgtgta agctcctctc 361 agggttttat cacacaggct tgtacagcga gatctttttc ataatcctgc tgacaatcga 421 caggtacctg gccattgtcc atgctgtgtt tgcccttcga gcccggactg tcacttttgg 481 tgtcatcacc agcaacgtca cctggggcct ggcagtgcta gcagctctc ctgaatttat 541 cttctatgag actgaagagt tgtttgaaga gactctttgc agagccttt acccagagga WO 00/09525 PCT/US99/17712 EPI-109 1104 601 tacagtatat agctggaggc atttccacac tctgagaatg accatcttct gtctcgttct 661 ccctctgctc gttatggcca tctgctacac aggaatcatc aaaacgctgc tgaggtgccc 721 cagtaaaaaa aagtacaagg ccatccggct catttttgtc atcatggcgg tgtttttcat 781 tttctggaca ccctacaatg tggctatcct tctctcttcc tatcaatcca tcttatttgg 841 aaatgactgt gagcggagca agcatctgga cctggtcatg ctggtgacag aggtgatcgc 901 ctactcccac tgctgcatga acccggtgat ctacgccttt gttggagaga ggttccggaa 961 gtacctgcgc cacttcttcc acaggcactt gctcatgcac ctgggcagat acatcccatt 1021 ccttcctagt gagaagctgg aaagaaccag ctctgtctct ccatccacag cagagccgga 1081 actctctatt gtgttttagg tcagatgcag aaaattgcct aaagaggaag gaccaaggag 1141 atgaagcaaa cacattaagc cttccacact cacctctaaa acagtccttc aaacttccag 1201 t 1 aatccttttc ctggcacctc tgatatcctt ttgaaattca tgttaaagaa tccctaggct 61 gctatcacat gtggcatctt tgttgagtac atgaataaat caactggtgt gttttacgga 121 ggatgattat gcttcattgt gggattgtat ttttcttctt ctatcacagg gagaagtgaa 181 atgacaacct cactagatac agttgagacc tttggtacca catcctacta tgatgacgtg 241 ggcctgctct gtgaaaaagc tgataccaga gcactgatgg cccagtttgt gcccccgctg 301 tactccctgg tgttcactgt gggcctcttg ggcaatgtgg tggtggtgat gatcctcata 361 aaatacagga ggctccgaat tatgaccaac atctacctgc tcaacctggc catttcggac 421 ctgctcttcc tcgtcaccct tccattctgg atccactatg tcagggggca taactgggtt 481 tttggccatg gcatgtgtaa gctcctctca gggttttatc acacaggctt gtacagcgag 541 atctttttca taatcctgct gacaatcgac aggtacctgg ccattgtcca tgctgtgttt 601 gcccttcgag cccggactgt cacttttggt gtcatcacca gcatcgtcac ctggggcctg 661 gcagtgctag cagctcttcc tgaatttatc ttctatgaga ctgaagagtt gtttgaagag 721 actctttgca gtgctcttta cccagaggat acagtatata gctggaggca tttccacact 781 ctgagaatga ccatcttctg tctcgttctc cctctgctcg ttatggccat ctgctacaca 841 ggaatcatca aaacgctgct gaggtgcccc agtaaaaaaa agtacaaggc catccggctc 901 atttttgtca tcatggcggt gtttttcatt ttctggacac cctacaatgt ggctatcctt 961 ctctcttcct atcaatccat cttatttgga aatgactgtg agcggacgaa gcatctggac 1021 ctggtcatgc tggtgacaga ggtgatcgcc tactcccact gctgcatgaa cccggtgatc 1081 tacgcctttg ttggagagag gttccggaag tacctgcgcc acttcttcca caggcacttg 1141 ctcatgcacc tgggcagata catcccattc cttcctagtg agaagctgga aagaaccagc 1201 tctgtctctc catccacagc agagccggaa ctctctattg tgttttaggt agatgcagaa 1261 aattgcctaa agaggaagga ccaaggagat naagcaaaca cattaagcct tccacactca 1321 cctctaaaac agtccttcaa accttccagt gcaacactga agctcttaag acactgaaat 1381 atacacacag cagtagcagt agatgcatgt accctaaggt cattaccaca ggccagggct 1441 gggcagcgta ctcatcatca acctaaaaag cagagctttg cttctctctc taaaatgagt 1501 tacctatatt ttaatgcacc tgaatgttag atagttacta tatgccgcta caaaaaggta 1561 aaacttttta tattttatac attaacttca gccagctatt atataaataa aacattttca 1621 cacaatacaa taagttaact attttatttt ctaatgtgcc tagttctttc cctgcttaat 1681 gaaaagctt (2) INFORMATION FOR SEQ ID NO:22: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 2961 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:22: 1 tctagagcca aggtcacgga agcccagagg gcatcttgtg gctcgggagt agctctctgc 61 tgtcttctca gctctgctga caatacttga gattttcaga tgtcaccaac caccaagaga 121 gcttgatatg actgtatata gtatagtcat aaagaacctg aacttgacca tatacttatg 181 tcatgtggaa aatttctcat agcttcagat agattatatc tggagtgaag aatcctgcca 241 cctatgtatc tggcatagtg tgagtcctca taaatgctta ctggtttgaa gggcaacaaa 301 atagtgaaca gagtgaaaat ccccactaag atcctgggtc cagaaaaaga tgggaaacct 361 gtttagctca cccgtgagcc catagttaaa actctttaga caacaggttt tttccgttta 421 cagagaacaa taatattggg tggtgagcat ctgtgtgggg gttggggtgg gataggggat 481 acggggagag tggagaaaaa gggggcacag ggttaatgtg aagtccagga tccccctcta 541 catttaaagt tggtttaagt tggctttaat taatagcaac tcttaagata atcagaattt 601 tcttaacctt ttagccttac tgttgaaaag ccctgtgatc ttgtacaaat catttgcttc 661 ttggatagta atttctttta ctaaaatgtg ggcttttgac tagatgaatg taaatgttct 721 tctagctctg atatccttta ttctttatat tttctaacag attctgtgta gtgggatgag 781 cagagaacaa aaacaaaata atccagtgag aaaagcccgt aaataaactt tcagaccaga 841 gatctattct ctagcttatt ttaagctcaa cttaaaagga agaactgttc tctgattctt 901 ttcgccttca atacacttaa tgatttaact ccaccctcct tcaaaagaaa cagcatttcc 961 tacttttata ctgtctatat gattgatttg cacagctcat ctggccagaa gagctgagac 1021 atccgttccc ctacaagaaa ctctccccgg taagtaacct ctcagctgct tggcctgtta 1081 gttagcttct gagatgagta aaagacttta caggaaaccc atagaagaca tttggcaaac 1141 accaagtgct catacaatta tcttaaaata taatctttaa gataaggaaa gggtcacagt 1201 ttggaatgag tttcagacgg ttataacatc aaagatacaa aacatgattg tgagtgaaag WO 00/09525 PCT/US99/17712 EPI-109 1105 1261 actrtaaagg gagcaatagL attttaataa ctaacaatcc ttacctctca aaagaaagat 1321 ttgcagagag atgagtctta gctgaaatct tgaaatctta tcttctacza aggagaacta 1381 aaccctctcc agtgagatgc cttctgaata tgtgcccaca agaagttgtg tctaagtctg 1441 gttctctttt ttctttttcc tccagacaag agggaagcct aaaaatggtc aaaattaata 1501 ttaaattaca aacgccaaat aaaattttcc tctaatatat cagtttcatg gcacagttag 1561 tatataattc tttatggttc aaaattaaaa atgagctttt ctaggggct ctctcagctg 1621 cctagtctaa ggtgcaggga gtttgagact cacagggttt aataagagaa aattctcagc 1681 tagagcagct gaacttaaat agactaggca agacagctgg ttataagact aaactaccca 1741 gaatgcatga cattcatctg tggtggcaga cgaaacattt tttattatat tatttcttgg 1801 gtatgtatga caactcttaa ttgtggcaac tcaaactaca aacacaaact tcacagaaaa 1861 tgtgaggatt ttacaattgg ctgttgtcat ctatgacctt ccctgggact tgggcacccg 1921 gccatttcac tctgactaca tcatgtcacc aaacatctga tggtcttgcc ttttaattct 1981 ctttttgagg actgagaggg agggtagcat ggtagttaag agtgcaggcr tcccgcattc 2041 aaaatcggtt gcttactagc tgtgtggctt tgagcaagtt actcaccctc tctgtgcttc 2101 aaggtccttg tctgcaaaat gtgaaaaata tttcctgcct cataaggttg ccctaaggat 2161 taaatgaatg aatgggtatg atgcttagaa cagtgattgg catccagtat gtgccctcga 2221 ggcctcttaa ttattactgg cttgctcata gtgcatgttc tttgtgggct aactctagcg 2281 tcaataaaaa tgttaagact gagttgcagc tgggcatggt ggctcatgcc tgtaatccca 2341 gcattctagg aggctgaggc aggaggatcg cttgagccca ggagttcgag accagcctgg 2401 gcaacatagt gtgatcttgt atctataaaa ataaacaaaa ttagcttggt gtggtggcgc 2461 ctgtagtccc cagccacttg gaggggtgag gtgagaggat tgcttgagcc cgggatgatc 2521 caggctgcag tgagccatga tcgtgccact gcactccagc ctgggcgaca gagtgagacc 2581 ctgtctcaca acaacaacag caacaaaaag gctgagctgc accatgcttg acccagtttc 2641 ttaaaattgt tgtcaaagct tcattcactc catggtgcta tagagcacaa gattttattt 2701 ggtgagatgg tgctttcatg aattccccca acagagccaa gctctccatc tagtggacag 2761 ggaagctagc agcaaacctt cccttcacta caaaacttca ttgcttggcc aaaaagagag 2821 ttaattcaat gtagacatct atgtaggcaa ttaaaaacct attgatgtat aaaacagttt 2881 gcattcatgg agggcaacta aatacattct aggactttat aaaagatcac tttttattta 2941 tgcacagggt ggaacaagat g (2) INFORMATION FOR SEQ ID NO:23: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 3383 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:23: 1 agaagagctg agacatccgt tcccctacaa gaaactctcc ccgggtggaa caagatggat 61 tatcaagtgt caagtccaat ctatgacatc aattattata catcggagcc ctgccaaaaa 121 atcaatgtga agcaaatcgc agcccgcctc ctgcctccgc tctactcact ggtgttcatc 181 tttggttttg tgggcaacat gctggtcatc ctcatcctga taaactgcaa aaggctgaag 241 agcatgactg acatctacct gctcaacctg gccatctctg acctgttttt ccttcttact 301 gtccccttct gggctcacta tgctgccgcc cagtgggact ttggaaatac aatgtgtcaa 361 ctcttgacag ggctctattt tataggcttc ttctctggaa tcttcttcat catcctcctg 421 acaatcgata ggtacctggc tgtcgtccat gctgtgtttg ctttaaaagc caggacggtc 481 acctttgggg tggtgacaag tgtgatcact tgggtggtgg ctgtgtttgc gtctctccca 541 ggaatcatct ttaccagatc tcaaaaagaa ggtcttcatt acacctgcag ctctcatttt 601 ccatacagtc agtatcaatt ctggaagaat ttccagacat taaagatagt catcttgggg 661 ctggtcctgc cgctgcttgt catggtcatc tgctactcgg gaatcctaaa aactctgctt 721 cggtgtcgaa atgagaagaa gaggcacagg gctgtgaggc ttatcttcac catcatgatt 781 gtttattttc tcttctgggc tccctacaac attgtccttc tcctgaacac cttccaggaa 841 ttctttggcc tgaataattg cagtagctct aacaggttgg accaagctat gcaggtgaca 901 gagactcttg ggatgacgca ctgctgcatc aaccccatca tctatgcctt tgtcggggag 961 aagttcagaa actacctctt agtcttcttc caaaagcaca ttgccaaacg cttctgcaaa 1021 tgctgttcta ttttccagca agaggctccc gagcgagcaa gctcagttta cacccgatcc 1081 actggggagc aggaaatatc tgtgggcttg tgacacggac tcaagtgggc tggtgaccca 1141 gtcagagttg tgcacatggc ttagttttca tacacagcct gggctggggg tggggtggga 1201 gaggtctttt ttaaaaggaa gttactgtta tagagggtct aagattcatc catttatttg 1261 gcatctgttt aaagtagatt agatctttta agcccatcaa ttatagaaag ccaaatcaaa 1321 atatgttgat gaaaaatagc aaccttttta tctccccttc acatgcatca agttattgac 1381 aaactctccc ttcactccga aagttcctta tgtatattta aaagaaagcc tcagagaatt 1441 gctgattctt gagtttagtg atctgaacag aaataccaaa attatttcag aaatgtacaa 1501 ctttttacct agtacaaggc aacatatagg ttgtaaatgt gtttaaaaca ggtctttgtc 1561 ttgctatggg gagaaaagac atgaatatga ttagtaaaga aatgacactt ttcatgtgtg 1621 atttcccctc caaggtatgg ttaataagtt tcactgactt agaaccaggc gagagacttg 1681 tggcctggga gagctgggga agcttcttaa atgagaagga atttgagttg gatcatctat 1741 tgctggcaaa gacagaagcc tcactgcaag cactgcatgg gcaagcttgg ctgtagaagg 1801 agacagagct ggttgggaag acatggggag gaaggacaag gctagatcat gaagaacctt 1861 gacggcattg ctccgtctaa gtcatgagcc gagcagggag atcctggtg gtgttgcaga WO 00/09525 PCTJUS99/17712 EPI-109 1106 1921 aggtttactc tutggccaaa ggagggtcaa gaaggatgag catttagggc aaggagacca 1981 ccaacagccc tcaggtcagg gtgaggatgg cctctgctaa gctcaaggcg tgaggatggg 2041 aaggagggag acattcataa ggatgggaag gagggaggta ttcgtgcagc atatgaggat 2101 gcagagtcag cagaactaug gtggatttgg tttggaagtg agggtcagag aggagtcaga 2161 gagaatccct agtcttcaag cagattggag aaacccttga aaagacatca agcacagaag 2221 gaggaggagg aggtttaagt caagaagaag atggattggt gtaaaaggat gggtctggtt 2281 tgcagagctt aaacacaazc tcacccagac tccaggctgt ctttcactga atgcttctga 2341 cttcatagat ttccttccca tcccagctga aatactgagg ggtctccagg aggagactag 2401 atttatgaat acacgaggta tgaggtctag gaacatactt cagctcacac atgagatcta 2461 ggtgaggatt gattacctag tagtcatttc atgggttgtt gggaggattc tatgaggcaa 2521 ccacaggcag catcagcac atactacaca ttcaataagc atcaaactct tagttactca 2581 ttcagggata gcactgaaca aagcattgag caaaggggtc ccatataggt gagggaagcc 2641 tgaaaaacta auatgctgcc tgcccagtgc acacaagtgt aggtatcatt ttctgcattt 2701 aaccgtcaat aggcaaaagg gggaagggac atattcattt ggaaataagc tgccttgagc 2761 cttaaaaccc acaaaagtac aatttaccag cctccgtatt tcagactgaa tgggggtggg 2821 qggggcgcct taggtaczca ttccagatgc cttctccaga caaaccagaa gcaacagaaa 2881 aaatcgtctc tccctccctt tgaaatgaat atacccctta gtgtttgggt atattcattt 2941 caaagggaga gagagaatt tttttctgtt ctttctcata tgattgtgca catacttgag 3001 actgttttga atttggggga tggctaaaac catcatagta caggtaaggt gagggaatag 3061 taagtggtga gaactactca gggaatgaag gtgtcagaat aataagaggt gctactgact 3121 ttctcagcct ctgaatataa acggtgagca ttgtggctgt cagcaggaag caacgaaggg 3181 aaatgtcttt ccttttgctc ttaagttgg gagagtgcaa cagtagcata ggaccctacc 3241 ctctgggcca agtcaaaaac attctgacat cttagtattt gcatattctt atgtatgtga 3301 aagttacaaa ttgcttgaaa gaaaatatgc atctaataaa aaacaccttc taaaataaaa 3361 aaaaaaaaaa aaaaaaaaaa aaa (2) INFORMATION FOR SEQ ID NO:24: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 143068 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:24: 1 aagcttcagt atgcaaattt tcaatgacat gtgcctgtgg attctgaaaa ttcacagatc 61 tgtctatcct tagctgagac tgaaggcatc tacttcccaa tgaccaaatc ctggtgctgt 121 ggcgacactg agcaggaact ccattagaat atcaatatca ctctgcagac attccatgat 181 gtaagctatg ttttctcttg ttgcaattac acttaattta ccaccagctg cttcaatgtc 241 atgggctatc ttgaaaaatg aagctccttt cgtagtcaaa ctggatgcaa gacacagcaa 301 atgagaagtt actaaattgt tggagtcctc atagctactg cctgctttaa tgaacaaacc 361 aattcttgat gcagggcata gttttccaaa ggagaaatca taaaaccatt tggaaatttg 421 atgatctcaa ggtcctgatg atgtggagcc actcctatgg gggtagctgt ggctttaact 481 ttgggggcaa ctctgaggga ataaagtctc aaaaagaggg aataaagtct caagattgtt 541 cgtgacccat aacaacttct ggcttaaagg accattcggc aagtttttaa atgtattttc 601 tataatttcc atgtagttct ttatattttc tatttcttat ttaaaacctc tattttagct 661 cgtttccttt gacactgctc tggcagggaa aggggtggca ctgcctcatt actgccaggt 721 aggggtagaa gtccattatc cacttggtct ccattgatac ccaaagtggg gagaggctcc 781 tgttactgct ggtgagggtg ggagtccccc cactaagttt ctgctaatac tgtcctggtg 841 gcttgctact attcccatga agcctccact gatactacat tacttttggg tggtggcaaa 901 tgtcctgcct ctccactagc cctcctgctc taaaacaacc cgagtaggga gtgggaagga 961 agctttgtta ctggtaggtg ggagcgaag tccagacttg ccacattgtc ccactgatgc 1021 tacagggagg aggaagcggg ccacattact gcctgatagg gatgaaagcc ccagctccct 1081 acctggcctt cgctgatacc agcctgctac aggagtgaag agagatttga aggcctcaat 1141 atagcctgtc gagggtggaa gtcttgctcc caatgggcct ttagcagcat gggtgggtgt 1201 ggggccatag ctgtctctgt actgcttggc tagagtggag tatttgaggt ccaaaagttt 1261 tctgtctttc tagccctttg gtagaaaga gcagactttt gttggaagta tttttttgtg 1321 tttacctgtt gtatttccag gttcctagct tctccagcac agtctgggat gtgtgagaca 1381 cagagaaaat ccagtgatgt tactaccgta tggtttcttg ggtcccaacg tctctagcta 1441 atctgctcca ccttttggag ttttcttatt tgttttagat cagggattta gtcatattta 1501 ataggagaaa tatggaaaaa tacttctact ctatcttcct ggaagttcct gtttattttt 1561 tatgtccttt tcctctggct agaccgtaag agacttacga aacaaacact tacacattct 1621 actaaactca atgtccaaag tttgtgaact tcttgaatat tgcttgttca tttccacccc 1681 cagtcactga ctgaatctcc ctgctgtctg tctacaatgc caatgagctt ctggttaact 1741 tcttctcatg catgcttagg caacaacttc ccagttttac tacacttgcc catccctagt 1801 tttgttgttg cttaatccct tggcctagtg ccaccatact cctccagcag agcaaccaat 1861 tcttacatta taggacagca catatccact aaaaacagtt catgccacac caaccacatt 1921 tccctttgtc aacaaaatta cttgatagat aattccagga atgcctgatg aagctgattg 1981 acaacaagat atttggcaaa ctctctgctg cctatacata ccttagcatg tggaactcaa 2041 gtaatgagag gtccatttaa ttggattgaa ttgggctgga taggattgga ttgaatcctg 2101 tgggatggct aggctaaatt agaaatgaag actagtttaa cagcagtatc caaggatagt 2161 tgactaatga gttaatttta ctctcaaaga cagtctttag agtaagctg taatgcatta 2221 tatcaaacta ttttccagc aatgatttatc aagttacttg aataaggatg ctaaagatgt 2281 gccttattga aatggcaatt aacacaaagt tgggaatgaa atctaattag ttaaataaca WO 00/09525 PCTIUS99/17712 EPI-109 1107 2341 gaatcacata aaaaaaaact tgaataaatg tagcatccta ccatgttcct ggatagaaag 2401 actgctatcg taaagarart cattctcctc aggttaaatt ataaactcaa tgcaattcaa 2461 caggatttta aaaaactaga caaagtgatt ccaagtttac gtggaaaata aaatgtgagg 2521 gaccaaacaa tatttgaaaa agaaagagaa taaaatctca tccttccaga taccacaatg 2581 tattataaag caatagtaat taacatgagg gcagaaatga gcaagcaagt gaacaaaata 2641 agacagatag tcacaggaaa ctcatatatt tataggtgct ttgcgtataa tgaagatggt 2701 ccttcaaatc agttgggaaa agatgggtta ttcaataaat ggtgttgggt aaaattggtt 2761 atacattggt gagaaataaa gtgaaactcc tactttgtat catatgcaaa aaatagattc 2821 cagacagatg aaatatttaa atgtaaaaaa taaaattcta aaactactag aaaaaaaaga 2881 agaatatttt tattcctttg aaatagaaaa ggtcttacta agcaaaacac agaagtaata 2941 aatgaataaa tgaagacaaa tatgataaaa ataagttaaa aatataagca atctttcttt 3001 gttttttttt cacctttoct agaaaaaaat atataggcaa cttgttaagc aaggtagatt 3061 acaagaaaat atttacaaca tttgacaggc cacagattat tatccagcct catctgataa 3121 gaaaacttca acataaagat atctgttttt tttcttataa ggttcctcaa agtgagccaa 3181 tcacttctta agctgaacaa aaaacaaaac agaagtgatc ttttccaata atgaaaacaa 3241 acattgacag agcagctgta ggatcctttc aggcaaatta tgaaaaggtg ccctttctca 3301 gaaaccacag ttaccattca gctttgtgac cagaggtttg actgtaccct agtccctact 3361 agcaacccaa ccacataacc aacttcaaag gtcctgaatg actgtgttgt acttaatggc 3421 agatgatcta tctcccattt ttgtcctaag gattttccaa gataatatat ttctgcattt 3481 gttttgcttt tacttcactc caaattgaaa tctatttgtg ggataagact aaagaaatgc 3541 ttataggaaa attgatagca ccaaattcct atcttaaaaa atgaaaaagg tttcaaatca 3601 atgacctcag cttttacttt aagaaaatag aaaaagcagg ataagctaaa gccaaagtaa 3661 acagaagaaa ggaaattata aagataagag cagaaatcaa tgaatagaaa acaaaagaaa 3721 aaaatcaaac caaacagctg attctttaag cagatctata aaattgataa aactctagcc 3781 agattgatca agtaaaaaag agagaagaca caaattacca gtattaagaa tgagagaggc 3841 aatatcacta cagatcctac agatataaaa agtataaggg catactttga ataattttat 3901 gactataaat taggcaactt agataaaaca aatttcttga aagacacaaa caaccaaagc 3961 tcacctaaaa tactcacaaa ttgaatagtc ttatagctat tacaaaattg aggccaggcg 4021 cagtggctca agcctttaat cccagcactt tgggagggct aggaaggcgg atcacgaggt 4081 caggagtttg agaccagcct gactaacatg gtgaaaccct gtctctacta aaagtacaaa 4141 aattagccag gcttggtggt gcgtgcctgt aatcccatct actcaggaga ctgaggcagg 4201 agaattgctt gaacctggga ggcaaagttg tggtgagccg agatcgcgcc actgcacttc 4261 agcctgggca acagaacaag actccgtctc aaaaaaaaaa aaaaaaaaaa aaattgaaat 4321 tatagttaaa agtcttccca caaagcaaac tctagaccca gatggcttca atggtaaatt 4381 ctactggaca atcaaacagg aaacagtaat aattctccac aatgtctttc ataaaattga 4441 tgcggaggag atactctcca actcattcta tgaaactagc attaccctga taccaaaatc 4501 atacagagac agtgtaggaa aacaacagat cagtatcctt catgaacata aatgaagtac 4561 aatgcagtct tatgcataaa tcagagcttc attgttctac agataaggta atgtaggatt 4621 gttggttgcc cctccaggtc tgttaaattc acctccttcc ccagagagca tccttcttaa 4681 ggacagggag cctcaatatg tcagtcctca cagcacctcc ctcagtcttc agcacttacc 4741 agctcatcac cacaaccgat accacattgg ataatttcat gaattacttt agagcaaatg 4801 caagagaaaa aatggatttt tatataggag aagaaggagg aaattcttgt ggatttggta 4861 cagaataggg ccaagggaaa attacagatg taaaaagaaa agtgtgtgaa atagtatcct 4921 tagtgctcac aaatacaatg atttcattgt ttttaaaaat aaaaaatgac aaatgtctaa 4981 tgcttggtgg taatgcttta ttgaatgtgt gttatacact ggttcctcat tcctgaagtt 5041 agaaataata ccttcctctt ttcatttggt tatgtttgct gaaacaaatc aaaggctgag 5101 attgaaacac atgctacttc aggtggatga ccttactact aagctcatca caacagcact 5161 tacagctgaa gaccccagag tcctacctaa cttttgtcac aacccagatt ttggccatgt 5221 agttctgggc cttaccatta aagcagacag aagtcagagg aatgactcct ttccacttga 5281 agtgagctgc aggcttctag gaaaggcaag atgcacattt ccctcctgtg gagcataaag 5341 cctttgtaat tcaggactta ggacccatat ggatttgaaa tattatgaca ttggagctgg 5401 agtggttggg gacaacacca gtagtgttat aggccatgga atgtcaaaag aacatggaac 5461 cctgttaaaa tcattaaaca tcaaaactct cccctcctct ggtgatatgg tttggctgtg 5521 tccccatcca aatctcatct tgaactccca tgtgttgtgg gaggcaccca gtgggaggta 5581 attgaatcat gggggcaggt ctttcccatg ctgttttcac gatactgaat aagtctcaca 5641 agatctgatg gttttataaa ggggagcttc cctgcacaag ctctcttctc ttgtctgcca 5701 ccatgtgaga catgcctttc accttccgcc atgattgtga ggcctcccca accatgtgga 5761 acttttaagt tcattaaacc tcttcctttt gtaaattgct cagtctcaaa tatgtcttta 5821 tcagcaacgt gaaaacagac tatctgattt tctgtgggat gtggattatg accatggaca 5881 gagcataact gggacagagc tggaaaaaat attaattagg tgcttaaaaa tatttgttag 5941 aactatcttc atgaatgaga atcaatcctg tttccatggt gattcaccag gcatcaattc 6001 caagcatcca tgaatcagaa aagtcctatc ttctcttagt tatcatccag gactccaagg 6061 aaccataatt agccaacctg ttcacatttc cttttcattc actagcctcg aagtttccag 6121 gggacaggga ctctgtccta ttcatttctg taaccttacc acctgaccca gaatagctgt 6181 tccctgaaga tttggtggat tataaatgtg gatgtcttat ttctttgaaa gtgtgagctt 6241 caggtactga tcacgttatt ccaattatca atttagtatc tttcttcacc attaaactgt 6301 gaaattcttg agggaagaac ctatgactga tttatctctg taaactcatg ccaccagtat 6361 tcaaaatcac acctagcaca tagtaaacac tcaatgtttg ttgaatgact gaaggaatgg 6421 atgaaaatga acctccttgc ttctgaccag tggatgagtt gcttggccgt gttcctacag 6481 cctagagctc atcccctaaa gcatctgaag ttacccatta gtgcaatggt tcttgaacgc 6541 tggtgttgat cagaatcatc tggatgccca ggttctctga aataagatag ggtctaggca 6601 tttgtatttt taccaaggag gtgtgatgga gtcagatgca agaaggctag ttgaagaaac 6661 cacatgagag tttagtgtag tgtattagaa gactggtttg gctctgtcgc tagtggctac 6721 atcatcttgc tcaagtcatg ccagtctcag gacctcattc agtctcttca gctgtaatat 6781 gggtgggctg caccacataa ccagaaagat cccttccagc tctacccact tacaacatgg WO 00/09525 PCT/US99/17712 EPI-109 1108 6841 tcaaatttgg tctgattttt taaatcgtag tacaatatat ataacazaaa attcaccatt 6901 ttagccactt taaatgtaca attctgtagc attaactaca ttcacattgt tgtgcaacca 6961 tcactaccgt ctacttccag aactcttcat cttgcaaaac tgaacctctg ttgtcattag 7021 tcactaacta ttcctctccc cccctccttc taggccctgg caatcaccat tctactttct 7081 gtcgctatga atttgactac tctaggtaac ttatataagt ggaatcacag catttgccct 7141 attatgactg gtttagttga cttagcacaa cctcctaagg ctcaaccaca ttttagcatg 7201 tgtcagaatt ttctttgttt ttaaggctga ataatattct gttgtatctg taaataacat 7261 ctttattcat ttgtccatca acagactgtt gagttcctcc catcttttga ctattgtgaa 7321 aaatgctgct atgaacctga gtgtacagac atctggttga gtactgcttt caattcattg 7381 tttatatgga tcatatggta attttatgtt taattttttt ggaactacta cattgttttc 7441 cacagtgtac atcattttac atttccatca gcaatgcaca aaggttccaa tttctccaca 7501 ttcttaccaa cattttttat tttctgtttc ttatttattt gtttazttat tctgagacag 7561 agtctcactc tgtcacctag gctggagtgc agcagggtga tctcagctca ctgcaacctc 7621 tgcctcccat gttcaagtga ttctcctccc tcagcctccc aagtaaatgg aattacaggt 7681 gcccaccacc acgcccaggt aatttttgca ttttttttag tagtgatgag gtttcaccat 7741 gttggtcagg ctggtcttga actcctgacc tcaagtgatc cacccgcctc agcctcccaa 7801 agtgctggga ttacaggtat gaaccactgc acccaggcca tittttgctt tttagataat 7861 agtcatccta gtgggtatga agtggtattt cattgtggtt ttgatttata tttccctaat 7921 gatcagtgat attgagcatc tttcaagtgc ttattggcca ttttcttctt tggagaaatg 7981 tctatgcaag tcctttgctc attttttaat ccagttgctt tttgttattc tttttgattt 8041 gaaagtgttc tttatacctc ttgtatacta atcccttatc agatatgatt tataaatatt 8101 ttcttctttt ccatggattg ccctttttac tctgttgata gtgttctttg atacaaaata 8161 atttttaatt tgaatgaagc ccaattaatc tatttttgtt tcttttgttg cctgtgcttt 8221 tggtgtccta tccaagaaac tgttgccaaa tccaatgtca taaagctttt tcccatgctt 8281 ccttctaaga gttttgtagt tacagctctt gtatttaggt atttgactat tttgagttaa 8341 tttttgtaca tcgtataaaa taagaatcca atttttattt tattttactt tttgtatgtg 8401 gatatccaat ttccccacca ccattcattg aaaagactgt ccttttccta tcgaatggtc 8461 ttggcaccct tgtaaaacat aatttgacca tatatgtgag ggtttatttc tgggctctct 8521 attctattct attctattct attctattct attctattct attctattct attctattct 8581 attggtccct atgtctttct ttattctagt accaccattt tgctcatcat aactttgtag 8641 taagttttga agtcaggaat cgtaagacct ccagctttgt tcattttcaa ggttgttttg 8701 attattcaag gtcccttgat agtccatatg aatttcagga tggatttttc tatttctgca 8761 aaaaaaaaaa aaaaaaaaaa aaaaatcatt gaaattttta aacagattgc attaaatctg 8821 tagattgttt tgggtagtat tgacatttaa caacattaaa tcttccaatc aatgaactag 8881 gctattttta tttatttttt ctgtttcttt gagctacttt tgtagttttc agtgtataag 8941 tttttgctac ctggttaggt atacttctaa gtattttcta ctttttgatg ctattgcaca 9001 ttgaatcgtt ttcttaattt ggtggtagcg gggattgtgc attgttagta cataaaaatg 9061 caactcattt tttgtgtgtt gattttgtat cctgcagctt taacaaattc atgttagttc 9121 taacagactt attctatgaa tcattagggt tttctacata aaagatcatg tcacctacaa 9181 acagagataa ttttactcca ccccttcccg ttgcaatgcc ttttatgtct ttttcttgcc 9241 taattgttct ggctaagact tccactacca tgttgaatag aagtggtgaa agtagacatc 9301 cttgtcttgt tccaatctta gagccaaagc tttcagtctt tcacggcctg aaagactttg 9361 taatatgttc tcaaggttaa agaacttcag aagttttcta agcaagagac cattttatta 9421 acttagttgg cagcaattct gagagattag aatgaaaaga tagaggataa gaagtatctg 9481 gcaggtataa tatattgagt gtgctgaata tacttttagt tttgtatagg tgttaaaaaa 9541 tggcaaagga ggccgggcgt ggtggctcac gcctgtaatc ccagcacttt gggaggccga 9601 ggcgggcaga tcatgaggtc aggagatcga gaccatcctg gctaaaacag tgaaacccta 9661 tctctactaa aaatacaaaa aactcgctgg gcatggtggt ggacacctgt agtcccagct 9721 actcgggagg ctgaggcagg agaatggtgt gaacctggaa ggtggagctt gcagtgagcc 9781 gagatcacgc cactgcactc cagcctgggc gacagagaga gactccgtct caaaagaaaa 9841 aaaaaatggc aaaggaaaga atgaaaaata aagcaaggtc ccagaagagg ccaaaaatct 9901 taatcaaaat tgactgaaca ttacggaatg aaatggtttt tcctttactc caattaacga 9961 cttcacaaga agattccatc ctcgtttata agattaaccc aaaaccagca cttaaaacca 10021 gaagccttga aaggatggag tttggggacc cttctcatgt ctattcccag aagggggtct 10081 tcttctgggg tcctgtcccc taaagagcta ggcaaaaagt atgcttgcca catctgttga 10141 aagatagaaa gttggtctaa aaatacatga gagggaactg aaacatttca gagaaggcaa 10201 gactcagaag taagaaacca aaagaggaag gtaaaattct agttacaaag aaaagaggaa 10261 tggaaattaa attgtcttac agagaaaatc cagaactgcc ccctcttccc ttactactcc 10321 atcaaaaaag gggaaaaata gtcaatggga aagttttgag aaaaatagat ctctgcattc 10381 ttctggttga gaattcagac aacttgaact agagagctgg gtaatttctt gactaaaggt 10441 gtgttagatc tgaaagggtt tttcttaaaa ttgtctgtgt tcatccctcc catcttagag 10501 aggaacacag gataagagac ctctggagct cccccagggt caccgagcta ataggatcag 10561 agacaaagct acaaagtcat tttctgacat ctctccaggg ctcttttttt ctggaccccc 10621 catatcaaca tgatgtattt attacattgg attagcaact ctccttgagc tttcctcagt 10681 accaggttta catctcagtc tgtgggtctc agagaaagta cccaatcagc agcaacatta 10741 cctggaaact catcagaagt gcccctcctc agccccaccc cagatctatg caatcagaaa 10801 ctctggaaat gcaggccagt cctaacaagc ccaccaggga attctggtgc actaaggttt 10861 gagatccact gatcaaagaa ataatattcc ttttcttcat tataatagca tgaataataa 10921 ctaacatgta tttcacaatt tacaaaagag ctttatgctc ttgttaaatt tgagggtagt 10981 cttctcaaaa tctctgtgag gctagaaagt cagatattga aacacctgtt ttatgggttc 11041 aaagataggt tcaaaagaga gtaaatgatt gttggggtgg caggtccaga gagggcagga 11101 tcaaaactgc aattgagtct tctgccttat aaaccagcat agcttcccca aggcacgtca 11161 cttctcgata aaatggtgac aactagagtg tcctttcaga tcattcttag aagcatggag 11221 tgctaggtca attgtgtaat tgatgaggaa ataataatac taagaaccc catcttctac 11281 gtccttatat acaatcctgt caggtagaag ctgagtctca gagagaacaa gttgccctcc WO 00/09525 PCTIUS99/17712 EPI-109 1109 11341 caggaccacc aggtaagctc ggcatagctg rgcttagaat gtaggctgtc tggcttctgg 11401 gcttgcctgc ccagggaggc tttgtgggtt ctacttggtc atccagatca cagaggggca 11461 gcactgactc ctacccagtg ctcttgactg tacatctaat actttctact aagaaaaccc 11521 cttctcttta gaccaatggt tttcaaatct tggtgtgcat tggaatcacc tggaaagctt 11581 gttaaaacac agattgtccc accccaagag tttctgattc tgtaggctgg ggtggggacc 11641 catgaaagtg catttctaat aaggtcccaa gtgatgctga tgccaccagt gtgtggacaa 11701 ccctttgagt ggtgaagctc tggacaccct aatttgcaag gctaatcagg catatgtggc 11761 aaatgaatac gaactgaaat tctgactcca atatcttcac tgatattcct aatccatagc 11821 atacacacag tcccattcgt ttccctttta gcttttaatc tacatttatc ctttcttcct 11881 ctgccactgc cttctctcca gttagctcaa accaggtaac acataaccgc ctcctaactc 11941 atccgcccag ttggtttctt tggctttaat ctagacttct tatctccacc agatttgcct 12001 taccaaagca ccaatttctt aaggcagggt tagaattaaa aatcttctgt tcctcctcat 12061 tgcctaaaac tcctaaactt atgattcaag gtcttccatg accttcatgg accagtctaa 12121 cgttttagcc tgtcctaagt gacatgcctc caccacatac ttcatgcttt ccactttctt 12181 tctccatgtc tttgttcatg catttccatt tcttctacct gcgatgtcct ccttcgccat 12241 ctctgtagat ttaaaaatcc tacagggctc atctcaaatg ccctttcctt catgaagcct 12301 ttcatgaaat ccccatcgag aggttttccc tcctctcagc tctccaaagc acagatgtct 12361 gcgtttgtgg ctattatctt acgttgtttt gtattaaaat ttctccagct ttacacattt 12421 gtcatcctct taaggacaaa catcttatta tggtcaatgt gaagctatag aggataattt 12481 aatgaaatat tccaagggct agtcattaca catgactgat ttatctctgt aaactcatcc 12541 acactcatcc acctgatttt gattggccaa gttaatgaat cagagaggaa aagatggtaa 12601 aaatataata aaaatctcct aggtagtctc acatcccaca gagccccagg taatgaaatg 12661 aggccctgag ataatacttt atgaacaata aaactccggg ttctattgac agtgaagcaa 12721 gacctgagag agaaggctaa attcccttgt gtctagctgc cacaatcttc tgagaataat 12781 ggcctttctt cccgtctgcc ttctgaatca taggcaaatt tttctctttg gtgatcccta 12841 atacagaaag gggaagtcaa ataaaatata tacaaggaga aggattctgg gagacagagt 12901 ttcttgattc ccttctgcat gctcctcctc aaaagccttt atgagcttac cttacattta 12961 aattctttta aacaaggcat tatgtggtct ggtcttttcc agctccacac accttcacac 13021 tacattcccc ccagctaatt ctgctctggg aacactgacc ttcttttagt tctttgaaca 13081 cattgatttc tggtcaagat gactcagtaa cttcaacctt tgttgtgccc ttggtgctgt 13141 gaagatatag atatatatta accactgcac accagaaatc agaaatagca caacagagaa 13201 taaagtcatt gagccatctt ctgagctcca aaagacaaat tttctccaaa aagacaaatt 13261 caggctctaa aacaatacct taaggaacca gaagtggaat agaaaattaa ggtggtaagc 13321 agggctaaac cacatgcctg ttgagcccag gtttggaaga agacaatggc aggtaggaat 13381 gtggtttctg atgggtaata ggtactgttt tcatttactt tctgttgctt ataacagaat 13441 atctgaaact gggtgcttta taaagaaaag gaatttatgt cttgcagtta gggaaactga 13501 gaagtcaaaa gttgagggct gcaattgaca agtgccttct tgctggtggg gatactctga 13561 agagtcttga ggtggtatcg ggcataccac tctcagtgag gggactgagc atactaggtc 13621 aggtctttct tcctcctttt ataaagctat cagtcccact cttatgataa cccattaatc 13681 cattaactga ttagccaatt aatccatgaa tggattaatt cattcatgag ggcagagcct 13741 tcctgaccca aacacctctt aaagactcca cctctcaata ctgccacatg ggggattaaa 13801 tttcagcatg agtttttgat gagacaaata ttccaatgat agcagttatt aaaagtacat 13861 gcttgagaga aggggattgg agtcagcctc agtgcttaaa ctcaaaagct aggatgaggc 13921 tctaacactc ctgaaagaag gagttgctgc tggctcctta ccagggctat atcttttaca 13981 gagcaggaga cctaaagagg caggaggacc cggacatcgt ttggaaacca agcactaaaa 14041 caggccatct gttatacccc caatatcctc tcaggacaag tgttttgaac cactcacaca 14101 aggactagtc tgggcaagtg ggctagatga agaaaccaca aaatagctaa gtggggagag 14161 aaagaccaaa aatactattt tattcaaaat gaaaatacaa tccaaaattc catgattcat 14221 gaagaaatca aatggtatgt gtcaggtggt tcttgcattg ctatagagaa atacctgaga 14281 ttgggtaatt tataaagaaa agaagtttaa ttggctcata attctgcagg cttcacagga 14341 agcatggtgc tggcatctgc tcagcttctg gagaggcccc aagaagattt gctcaaggca 14401 gaaggttaag ggagagctgg cacatcacat ggtgagaaag gaagctagag agagagtgca 14461 gggtgaggtg ccacaagtta ccacagccag atctcttgag aactcactta ctttcatgag 14521 gacagcacca agccataagg tgtagggagc caaagtccca tgggacatga ccaactcagc 14581 attccactgg aggctatatg atcaaacagc aaactgttta tcacgaatgc aggatgtgag 14641 caaactcaca actggtcctg ccaacagaag gtttgttgga ggcaatcact ccctggtgcc 14701 tgaggtaatc tactgcaaca tctagagaat gcagtcttgc aagcctactc tggacagggc 14761 agctggcacc ttattccatc ccccttctca ctatcttttt ttgcctaata aatacagagg 14821 gctgtgtaaa gctcagggcc cttgtccact agaggcaagt tgccccctga ccccttcttc 14881 caaatatact cttttgtctc ttgtctttta ttctcacatt tgcccccttt gttcagttcc 14941 actaggtccg tgcgggttat atactggtgc cctgagcagc aacagaatca ggctctcaac 15001 aagtgtcatc cgaacatggg actttgagga catgaacgaa gaaggtctgc tggagcagag 15061 gaacagaaat tgacaaggtg aacagggacc ctgggacgag tctgccagca gcggatataa 15121 ggtcagttac ctaaagaggt actgatcagt gccctaaaga gatactggga gcagtgcttt 15181 aaagaagtac tgggaatggg aaattttctg aatcagggta acaaggggaa gaatttgtct 15241 attaaagaaa aacattatgt gcagttgctt aaagttgtat tggaacagtc tggagcttag 15301 gttaatttgc agacactaac tatcacatgc gtccgtgtga agagagtcca ccaacaggct 15361 ttgtgtgggc aataaagcct tttaatcacc ttggtgcagg tgggctgagt ccaaaaaagg 15421 agtcagcaaa gggagataga ggtggggcag ttttatagga tttgggtagg tagtggaaag 15481 ttacagttaa aagtggttat ctcttgtggg cagaggcagg ggtcacaagg tgctgggtgg 15541 ggaaatcatg agactctttt tctgggacag gagtgtcaca aggtcaattg atcagttggg 15601 gtggggcagg aacaaatcgc aatggtggaa tgtcatcact taaggcagga actgactatt 15661 tcacttcttt tgtggttctt cagttgtttc gggccatctg gatgtatagt gcagctcaca 15721 ggggatatga tggcttaggt tgggctcaga gacctgacat tcctatcttt ttatattaat 15781 aagaaaaaca aaacaaaata gtggttaagt gttggggcag caaaaatttt ttggggtggt WO 00/09525 PCT/US99/17712 EPI-109 1110 15841 atgtagagat aaggggcaat gtttctcagg gctgcttcaa gcacgatcac ggtggtgtgg 15901 gaatctagag Lgggagagat taagctgaag aaaaattttg gggaaagggg tgatattctg 15961 gggttgttag aaggagcatt tgtcatatag aatgatgatg gcctggatgt ggttttgtat 16021 gaattgagaa actaaacgaa agacacaagg tccaaataag agaaggagaa aaacaggcat 16081 taaaggatta agaattagga ggacacagga catccaatta gagagtgccc aagggggtcc 16141 agtgtaatta tttgcctgga caatgagttt tggggctcta ttaggttgtc atataccagg 16201 ccagattgat ttaggtaaaa acaacactct tcatttaaaa tatacagagt cctccttttt 16261 tagcagtgag taagttgaga cctattcctg tcttcttata ttaataagta aaataaagca 16321 aaatagaggt gaagtgttgg tgtcatgagg ggaacaggaa gcagttcggt cctatttgca 16381 aattgatttt gggggggraa agaaaactag tgtacctttg cctgtccaat taataagtag 16441 acacatgtag atggaggagc cacagaggaa gaagagaact ttgtaaggca aaactggaaa 16501 tgtaaaggga aaagataaga gggagcacca aaagaggtgt cttgcaccca gactcaggga 16561 tctagtgaga gcagcaacrg ttagaggttg taatggggat taatggggct actgggtaga 16621 gggggaggtt caactttzat ggtgtatgag aaagcgcata gtgtctacaa gcaacctttc 16681 attgctattc ataggaztg gtataagtaa acaagaaggg ggggctagga ggagagtctg 16741 aagaacaagg ggaagg-agc caaggatgga gtgaaatgta gggcaaatgt cttaaaggaa 16801 atgagaggtt ctaagaggag ggctagtggc ttgtaaccca catggaagag gttacgaaag 16861 gatgatagaa tggaatgagc ctgtgaggct ggaaggagga attttccttg gtccaagaac 16921 catttgcctt gtgtgggaag agtttgatag gtggaagttt cagtgggagg gtaggcggga 16981 gtgactgatg agaaggagaa aaactggcca taagggacag aagttggaat gctagctgct 17041 cctttagcta ccttatcagc ataagctttg ccctgagtga tgggatctga tgccttttga 17101 tggcgcttgc agtgaatgac cctagcttcc ttggaagtag agcagcttta agaagagttt 17161 ttatgaagaa ggcattaata atggaggacc ctcgtatagt gaggaaacct ctttcaggcc 17221 atataacaga atggaggtgg agaatatgga aggcatattt agagtcagta taaatactga 17281 cacacaatcc ttttgcaaga gtgagggctc gagttaaggc aatgagttcg gcttgctgag 17341 agggagtgga gtggggcaga gtggtagcct caatgataga tgtgaaagat actatagcgt 17401 agcctgcctt tgctggtgag tggtgattag gcctagtgga actgccatca ataaaccaag 17461 tgtgatcaga gtgaggaaca ggaaagaagg aaatatggga aaatggagtg aatgctaggt 17521 ggatcagaga gatacagzca tggggatcag gtgtggtatc aggaataatg tgggaggcca 17581 gattgaagtc caggccagga acaatggtaa ttgtgggaga ctcaacaaag agtgagttca 17641 actgaaggag ccgggggagg gggagagcgg cagaaagtat atgcatcagg tgtgaggaag 17701 aaaatacatt ttgaaaatta tgagaactgt agagagtgag ttgatcatag tttgtgattt 17761 tgagggcctt taaaagtatt aaagcagtgg cagctgccac acacagacat gagagccagc 17821 ctaaaacagt aaggtcaatc tgtttagaca gaaaggctgc agggcactgt ccaagctctt 17881 gtgtaaggat tctgaccgca cagccttgta ctttggctgt gtgtaatgaa aagggttggg 17941 atgagttagg gagagctagt gtgggagtag cttctagggc tgtttttaag gaacataaag 18001 aggagtgggg aaaggattta ggatctatgg ggtcagctag gtttcctttt gtgagtttat 18061 gtaatggttt agtcaggatg gcaaaaccag gtatccaaag gtgaaagtac ccaaccatgt 18121 ctaggaagga aaggatttgt tgctttgtag aagggattgg ggtttgggag attagccgga 18181 cacagatcag gagggagagc acttgtattt ttatgaagaa ttatgccgat aggtaacgga 18241 tgaggaagaa atttgggctt tggaggggga tacacgatat tcccttgaga atagatgttg 18301 gaggagcagg agggtgtcct gttgggaaga ttcataggag gggctataaa gtagaaggcc 18361 atcaaaatat tgaataaggt gacaagcaga tggacagaaa agtaaattat gagaaagggc 18421 ttgactgaag taatggaggc tgtccctgaa gccttgtggc agtacagccc aggtaagttg 18481 ctgagactga tgggtgtcag ggtcagtcca agtgtaagtg aagagaggct ggggtgaaga 18541 gtgcaaagga atagtaaaga aagcatcttc aagatccaga acagaataat gggttgtgga 18601 gggaggtatt gaggatagga gagtatatgg gtttggcacc acagagtgga taggcaagac 18661 aatttggttg ataagctgaa gatcctggac aggctttagt cccttcaaag cctgttgtgg 18721 gatgggatac tggcattgag caggataagg gtaattaggt tttaatggga tggtagggtt 18781 gcgtgatcgg tcaccaagga gggagtagag gtatcccata cttgtgggtt aagataggga 18841 gtcaggaggg gaggttgtga aggaggcttt gaactgggga aaagggtggc aatgaggtgt 18901 ggctgtagcc caggaatagt cagggaagca gataatttag ttaaaatgtc tcaatttaat 18961 aagggagctg ggcaggtggg aataactaaa aaggagtgca taaaagaatg ttgtccaagt 19021 tggcaccaga gttggggagt tttaagaggt ttagcagcct gaccatcaat aaccacaaca 19081 gttatggagg caagggaaac aggcccttga aaggaaagta atatggagtg ggtagcctcc 19141 atattgatta agaaagggac agacttaccc tccactgtaa gagttaccca aagtgtctgt 19201 gatgatccag gaggcttctg aggtgatcag gcagtgtcag tcttcagctg ctaagctgag 19261 aagatctggg aaggagtcag tcagagagcc ctgggccaga gttccagggg ctctgggagt 19321 ggctgacggg caagttggac agtccgattt ccaatgcggt cccacacaga tgggatacag 19381 tttaggagga atcctgggct gtaggcattc cttggcccag tggccagatt tctagcactt 19441 gaagcaagat cctggaggaa tgcctgacca cagtggttta ggtgttttga agttcttgtg 19501 tgctggagat gtggctgagg tttttctcac agcagaggca agtaattgca actcagaaat 19561 acattgccac ttggctgtct cttctctatt attgtacacc ttgaaggtga ggttaattaa 19621 gtcctgttgt ggggtttgag ggccataatc taatttttga agctttttta atgttgggag 19681 tggattgggt aataaaatgc atattgagag taagacagcc ttctggcccc tctgaaccta 19741 gggcagtaaa atgtctaaga gttgttgcca aagggaccat ggactgggct gcgttttcat 19801 atttgatgaa aaaaaaagag cctaaatgct aactaatttg ggagaggtca gataaagtaa 19861 aaggaacatt aatcttgact atgccttcag ctcttgccac ctctctaaga ggaaattgtt 19921 gggcaagtgg aggagtgcta gtcgtggaat gaaaccataa gctggactgg gtgtgaggag 19981 gggaggtgat agaaggatta cagcgtaggg gagtagaggc tgaqgaagaa ttgggacctg 20041 gctcagcctg gtgaggagtg gcctggtgag gagcagcctg gggaggagga gagaggttag 20101 atgggttcgt agaaaagaag gattcaaagg actcggagct tggtgaggag actgaaggaa 20161 cagacaggag agaaagaaga aagatttggg acaagtcgca ttgggagcag agactaggaa 20221 gggagtgatg tgtaaaaaat gcctggacat caggcacctc agaccatttg cccattttat 20281 gacaaaaatt atctaagtct tgtagggcgg agaaatcaaa agtgccattt tctggccatt WO 00/09525 PCTIUS99/17712 EPI-109 1111 20341 tggaacaatt atcgagtttg tattggggcc aaatggtgtt gcagaagaaa ataagatgct 20401 taggttttag gtcaggtgag agttgaagag gttttaggtt ttttagaaca caggctaagg 20461 cagaagaagg aggaatggag ggtggaaggc tgcccataat aaaaaggtaa gtttagagaa 20521 aagagaggat agagacacag agagaggggg tggtggtact catcagccag gggaggtggt 20581 acttgccacc aaggtgatgg atcaaggcag tcatccccac ggtgatcaga cacctctgaa 20641 atgtgggtga ataatcaggc aggtgtccct gcagtgatta gacaccaagg ggagactgtc 20701 ttcccgagtc cgtgaccggt gctggagttt tgagttcaca gataaaacac atctcctctg 20761 tctctaccag aaagggaaag gaactgaaat taaggaaggg agagattgaa gggtggagag 20821 atagcaagag agttggaaaa gagaataaaa agaggccact tactcaattt aaaattggtg 20881 agatgttcct tgggctgatc tgaggaccca aggttgtagg tggatctcct cacggaatga 20941 gggtgaggac aggggactgg tctccagaag gagttcccga gtcctggatc ttcagcacca 21001 aatgtcatgt gcatccatgt gaagagagtc caccaacagg ctttgtgtta tcaataaagc 21061 tttttaatca ccttggtgca ggtgggctga gtctgaaaaa ggagtcagca aagagagata 21121 ggggtgggtc agttttataa gatttgggta ggtagtggaa agttacagtt agaggtggtt 21181 atctcttgag ggcagaggtg ggggtcacaa ggtgctgggt ggggaaatcc tgagacttat 21241 catccaggga aggagtgtca caaggtcgat tgatcagttg gggtggggca ggaacaaatc 21301 gcatggtgga atgtcatcag ttaaggcagg aactcactat ttcacttctt ttgtggttct 21361 tcagtttctt caggccatct ggatgtacac gtgaaggtta cggggatata tgatggctta 21421 gcttgggctc agaggcctga cactaacctc ctgcagaagc cacaaaaggt tattacacat 21481 aaaccatggt ttccacaggc aggcactctt gatgtggaaa attgggatag agoaggatta 21541 aaacaagctc atcaaaaagg tcttaaagtt gattcttcag ttttctccac ttggagttta 21601 gttcatactg tacttctgcc attatctcct tattattctg cggaacagca ggctgaatct 21661 aaaaattgga aagaatttgt tgtcctactc acagctccaa ttgaatataa aaaacaggag 21721 agggaggata aaaattggcc tataccgcct cctccagatg cagaaacatc tgtaccatct 21781 ccttcagtgg cagaaataga gatcccagta caaagaattt tatgctctgc tgtcatagct 21841 ggagagccct taggaccttg tgcttttcct atttctgtaa ggcctgatcc aaataatcca 21901 cagcagttta ttcatgaaca ctctccacta gaatttaagt tgttgaagga attaaaaact 21961 agtgtggtca ataatggagt acaaagccaa tggttcctgg aggaaggaat gctagacata 22021 gaactttggg agcaagtggg gagaaatctt aaacaacacc aggcacaaag gcatcaggtc 22081 ccagtaaaat cttttatgtt aggggctttg agtagagcag ccctggttgt tacacacaaa 22141 agagcctaaa aagggaaagg aggaggaaat gtcacctgcc ttatcacctc cccttccctc 22201 agtgccaata tcactgggcc aaaataacaa agaggaaatg gaggtcttac ctaagcttcc 22261 tcctccaata gataggaaga aggacagagg atacgctaca gctatcagtc cctgtcttaa 22321 gcaggcagca ttagaaggag agctcttagc cgggtgcagt ggctcatgcc tataatccca 22381 gcactttggg aggccgaggc aggcagatca tgaggtcagg agatccagac catcctagct 22441 aacatggtga aaccccgtct ccactaaaaa tacaaaaaat tagccaggca tgttggtggg 22501 cacctgtagc cccagctact tgggaggctg aggcaggaga atggcatgaa cccaggaggt 22561 ggagcttgga gctttcagtg acctgagatt gcaccactgc actacagcct gggcaacaga 22621 gcaagactcc atctaaaaaa agaagaagaa ggagagctct taacctgctc agtaatgcaa 22681 aatcggcaag gcaatcaggt gtatgtttat aaaaagataa gaaaaaggca ttagaagcca 22741 aaaccacgtg gccaagcagg cagtgggcag gagaaaatgc tcagaggcag aaaagctcac 22801 agcgacaaag ccaacaaggt ctgcccagga cggcagcatc cctctggcaa aggagcaagg 22861 gagcagcaca gacacaggca aagcctaaac aagtacaatg tggccacctc ccaggacctg 22921 caccactgcc ctctggctct gtgggcagcc cattgcaaaa tttcatgtgt tacatctcag 22981 gctatgattc tctgctaaga tgtaagtaaa atgtaagaat ttgaaaagca tcttttctaa 23041 taatggccac tattgtcatc tctctcctat ccctgatgta gctttccaaa ttcaatttaa 23101 gtaaaacagt aacctttgaa gggaaagaga ttacagaggg cccatgaatt agttgaagag 23161 taattaaaag ctaggcatgt aaaaccacac attacgcttt aaagaagaaa tttaaaccta 23221 attaaatgat atttgttaaa ttagaaggta aaaatgttgt gccctgttgg gaacaggccc 23281 ccaaatctgg ccataaactg gccccaaaac aggccataaa caaaatctct gcagcaccat 23341 gacatgtttg tgatggccat gatgcccacc ttgaaggttg ttggtttact ggaatgaggg 23401 caaggaacac ctggcccacc cagggcagaa aattccttaa aggcattccc aaaccactaa 23461 tgatagcatg agcaatctgt gccttaagga catgttcctg ctgcagacag ctagccagag 23521 cccatccctt tgttttggcc catccctttg tttcccataa ggaatgcttt cagttaatct 23581 atgatctata gaaacgatgc ttatcactgg cttgctgtca ataaatatgg gagtaaaact 23641 ctgttcaggg ctttcagctc agaaagccat aagccccctg atttcccact tcccaccctt 23701 tatttctgtg tgtgtgtctt gaattcctct agcgcctctg ggttatggtc tccacaacca 23761 cgctggtctt ggcagtgccc ttctcagaaa gtgaaaaaga gttgtatgta agtgtagtga 23821 aaacataagc atgaatcact gtcttaaccc actgattaga tagtctttga tttgtacttg 23881 ctaaaagagt cctaaattga gttcctcagc tagtgagtca ctgttttcaa gactgtttgc 23941 cagattgaag tccataaact tggtcagccc gaaaactcaa ttacaagatc taagctattc 24001 tgcctgtggc tttaagcaca tggttaaagt atattattta agtctctcct tctagatatg 24061 ctttcagatt ttctttttaa acttcttgtt acttatttca gctttccata ttgataatta 24121 atgcagtcaa ttgctcagtt atgactgtga tatcatcagg attcctttaa gtaaaaggca 24181 attcaaagcg gtattgcact cccccatacc taatgcttta acactgttta ctgatgggtc 24241 tggtaaacat ggaaaagctg cagtctagta gagaccacat aattcaatca ctcgatctga 24301 gttcactagc actcagagag ctaaggttac tctgtttatt tattaaagaa tttttacaac 24361 cttaagctca ctctggactt tccagcctta tgtggcaaat gtagccatca atttatgggg 24421 tcaagactta cttacagcat gggatatgag gcttacaaat gagactttga taacccagga 24481 ttttaaatgt tgaagaacac gggatatcag agtgaaaaag gtttagggaa aattctgaca 24541 agggaaaatt ctaacctgat atcaataact ggaaagacag gttaaaccct gcaaggggat 24601 acatgacat tttttcttcc tcacttgctc ttttctgctg tctgaatatg ggcatgaggg 24661 caagagtcat tttagaccac caagtgacct tgaggaaga agccttatac tagaggtggt 24721 gggaaagaaa aaacagaagg actcataaag aaaaaaataa taaacctcag tattaagatg 24781 gaaaaattcc cccaattggt ctataggttg aacttcatct ctattaaat tcagcctctgt WO 00/09525 PCT/US99/17712 EPI-109 1112 24841 ttttgcagaa tttgatatgc tgatcataaa atttatatga aaatgcaaga gacacagaat 24901 agtcaaaact ttgaaaagaa gaaagttgga ggacttacac ttgttgattt taaggctttt 24961 tacaaagcta taataatcaa gacaatgtgt tactgacata atgatagaca tattgatcaa 25021 tatagacaat ggatgaatgg agtagaattg acagtctaga aataaaacct tatatatatg 25081 gtcaatttat ttctttatgt attctgtcat ccagaataca taaagaacac cttcaactca 25141 ataacaacaa taccaacaag ggtgccaaga ccaatcaatg gaggaaataa tagtcttttc 25201 aagaaatttt gctgagacaa ctaagtattt atatgcaaaa taatgagttt gaatggctac 25261 catatacaaa aattaactca aatggactat attaggtcag tgcaacagta attgcagttt 25321 accaccatta cttgtttttt ttttttggtt tttttttttg agacagagtc ttgctctgtc 25381 acccagacca gagtgcagtg gcatgatctc agctcactgc aagctccact tcctgagttc 25441 acgccattct ccttcctcag cctcctgagt agctgggact acaggcatct gggtaatttt 25501 tttgtatttt tagtggagat ggagtttcac catgttagcc aggatggtct caatctcttg 25561 acctcgtgat ctgcccacct cagcctccca aagtgctggg attacaagca tgagccacca 25621 cgcctggcct accattactt ttaatggcaa aaatgcagtt acttttacac caccctaata 25681 gaactaaatg taagagctaa aactacaaaa ctgttagaag aaagcatagg agcaaatctt 25741 aatgacatga gagttggcaa ttgtttttta gatatgacac caaaagcatc aaggacaaaa 25801 gaaaaaaatg gataaattgg acttcctcca aattaagaga acttttgtcc tgcaagcaat 25861 actattaaga aagtgaaaag acaagtcaca aaatgggaga acatttttgc acataatata 25921 tttaataata ggctgacatc cagaatacat aaatacctac aactcaatac caaaaagaca 25981 gcccaattta aaaatgggcc aaggatatga ataaacattt ctctaaagaa gatacaaaaa 26041 tggtcaatat gcacatgaaa agatgctcaa tatcaatatc tattaggaaa atacaaatta 26101 aaacacaaaa tataaaacac aagatatcaa tttacactca ccaggatggc tgttatcaaa 26161 aagacagata acaagtattg gcaaggattt ggggaaattg taaccttcat acattgctgg 26221 taggaatata aaatttgcag caggtttgga aaacagttta gcagtttctc aaaaagcctg 26281 ggcatggtgg ctcatgccta caatcccagt gctttaggga gctgaggtga gaggattgct 26341 tgagcccagg agttggagac cagcctgagt aacacagtga gaCCtCtttt ctaccaaaaa 26401 gaagagagtt aaacataggg taccatataa gccagcaatc catctcctag atatgtaccc 26461 aagaaagttg aaaacatata ctgacacaaa aacttacata tgaatctca tattagcctt 26521 ataataatag ccaaaaagta gaaacaaccc aaatacccat caactaatta aaatatggtg 26581 tatctataca tattatttgg ccataaaagg aagtactgat acatgtcata acacaaatga 26641 accttggaag cactatgatc tctgtattag tcagctcttg tattgctata aagaactacc 26701 tgagactggg taacttataa agaaaaaggc ttaattgagt cacagttcca caggctgcac 26761 agggatcatg gcccaggaga cctcaggaaa cacagttatg atggaaggaa gagagtgaag 26821 gaggaggtgc tacatacttt taaaccacca gatcttgtga gaagtcactc actatcatga 26881 gaacagcaag ggagaagtcc acccccatga tccagtcagc cccagccagg ccccaactcc 26941 aatattgggg attacaattc cacatgagat ttgggtgggg acactaatcc aaacaatatc 27001 attctgcccc agcccctccc aaatcctgtg tccttctcac attggaagat acaatcatcc 27061 cttctcaaca gtttcatttc agtattaact caaaaatcca aagtctcatc tgagacaaga 27121 caagtccctt ccacctatga gcctataaga tcaaaaagaa gttagttact tccaagatac 27181 aatggaggta caggcattgg gcaaatatat ccattccaaa agggaaaaat tagccaaaac 27241 aaaggggcca caggccccac gcaagtccaa aatcaagcag ggaaatcatt aaatcttaaa 27301 gcttcaaaat gatatccttt gactccatgt ctcacatcca ggccacacca atgcaaggag 27361 tgtgctccca aggccttggg cagctctacc ctgttgctct acagggtata gcccccatgg 27421 ctgctttcac aggctggcat tgagtgcctc cagcttttcc aggtacacag tgcaagctgt 27481 tagtggatct accattctag ggtctggaag attgtggccc tcttctcata gctccagtag 27541 acagtgcccc agtggggaat ctgtatgggg gctgcaaccc cacatttctc ctctgcactg 27601 cccaatagag gttctccatg agggctccat tcctgtagca tacttctacc tggacatcca 27661 ggtgttttca tacatcctct aaaatctagg taggggctcC caagccttaa ctcttgccct 27721 ctgcacatcc gcaggcttaa taccacatgg aaaccaccaa tgcttatggc ttgcacccta 27781 tgaagcagta gtctgagaca tatctgggcc cttttggcca tggctgggat gcagggaaca 27841 gtgtcctgaa gtggcacagg gcagcggggc catgggcctg gcccatgaaa ccttctttcc 27901 tcctaggcct ccagacctgt gatgggaggg tctgcctcga cggtctctag aatgtgtttg 27961 aggcatattc ctcattgtct tggctattaa tatttggctc ctctttactt atgcaaattt 28021 ctacagcctg attaattcct ttccaaaaaa atggggtttt cttttctact acatggtcag 28081 gtcacaaatt ttccaaactt ttacgcttcc ctttgaaatg taagttCcag ttgcaggtca 28141 tttctttgat cacaaatata agcatatatt tgtagaatca gccaggccac atcttgaatg 28201 ttttgctgct tagaaactgc ttccaccaga taccctaaat cattgctatc aggttcaaaa 28261 ttctacatat ctctagggca agggcacaat gcctccaaga cctttgctaa tgcataagaa 28321 aattgacctt tgctccagtt cccaataagt tccccatctt catctgaggt ctccttagcc 28381 tggacttcat tgtccatatc agtatcagca ttttcatcac aataatttaa ctagtctcta 28441 agaagttcca aactttccct tatcttccta tcttcttctg agccctccaa actgctccaa 28501 cctctgccca ttacccgggt tccaaagctg cttccacatt ttcggtatct ttatagcaat 28561 gctccattcc tgataccaat tttctgtatt agtctcttct cgcacccctg taaagaacta 28621 cctgagactg ggtaatttat aaagaaaaga ggtttaattg actcacagtt ccacaagctg 28681 tataggaagc atggttcaga aggccacagg aaacttacaa tcatggagga aggcgaagag 28741 aaagaaggca cgtcttacgt ggctggagta ggaggaagag agtgaagggg gaggtgttac 28801 acacttttaa acaaccagat cttgtgagaa ctcactcact atcatgagaa cagcaaggga 28861 gaggtctgcc tccatgatcc aatcacctcc taccaggctc ctcctccaac attggggatt 28921 atgatttgac atgagatttg ggtagggaca caactccaaa ccatatcaat cccatttata 28981 tgaaatgtcc acaatagata aatctataga gacataaaat agattggtgc ttgcctagtg 29041 ctggacgtga caggagggtg tgagtaaaag aggcaatgga gtgataggta cagggtttct 29101 ttttggggtg atgaaaatat tataaaatta gattgtggtt atagttatat aactcttgaa 29161 tatcctaaaa atatattgaa ttttccattt ccattttaaa tgggtgaatc ttatggtatg 29221 tgaattatat ctcaataaaa ctgcaaaaaa tgcacaattt gcaattacaa aaatatggaa 29281 ccagtccaaa tgcccatcaa tgagtggata aaggaactgt ggtatatata tatatatata WO 00/09525 PCTIUS99/17712 EPI-109 1113 29341 tatatatata tatatatata tatatatata tatatataca cacacacaca caccatggaa 29401 tactactcag ccataaaagg gaataaaaca atggcattct cagcaacctg gatggaattg 29461 gagaccatta ttctaagtga aataactcag taatggaaaa ccgaatatca tacattctca 29521 ctcataagtg ggagctaagc tatgaggatg caaaggcata agaatgatat aatggacttt 29581 gggaactcag ggaaagggtg agagaggggt gaggaataaa aggctaccca ttgggtacag 29641 tgtacactgt tcaagtgatg gctgcaccaa aatctcagaa atcaccacta aagaacttat 29701 ttacataacc aaataccacc tgtttctcaa aaacctattg aaattaatta atttttaaaa 29761 actgctgaaa ccaatagtga aaggatggac tattcaataa tgacacagtt aattgaatat 29821 catattttaa aaattagatc cttacctcac actataacat aacaataaat tccaggtgaa 29881 ttatagacca aatatgaaaa gcaaaatttt aatattttag aagacaattt ttatgacctt 29941 aagttagaaa atgattttta aaaacaggat gcaaaaacac taatcataaa gagatatttt 30001 aggccaagca tggtggctca cacctgtaat cctagtactt tgggaagctg aggcaggtgg 30061 atcacttgag gtcaggagtt caagacaagc ctggccaata gggtgaaaca tgtctctact 30121 aaaaatacaa aaattagctg gaaatcgctc gaacccagga ggcagaggtt gcagtgagct 30181 gagattgtgc cactgcactc cagcctgggt gacagagaga gactccacct caaaaaaata 30241 aataaataaa aataaagaga gattttaata aggtgcatta aaataaaaaa ctatccatca 30301 aagacaccat gaataaagtt aaaataggcc acaatgagaa tatatttgcc atgaattttt 30361 tctttttttt tgagatggag tcttgctctg tcacccaggc tggagtgcag tggtgcaatc 30421 tcggcttact gcaaacttca cctcccaggt tcaagcaatt ctcctgcctc agcctcctga 30481 gtagctggga ttacaggtgt gtgccaccat gcctggctaa tttttgtatt ttttgtagac 30541 acggggtttc accatgttgg tcaggctgag ctcaaacccc tgacctcgtg atccaccttc 30601 ctcagcctcc caaagtgctg ggattacagg catgagccac cgtgcctggc ctaccatgaa 30661 tattttttta aaggtagcat ccagaattaa taatcttctc caacaaattt cattagtagt 30721 cagggaactg caaattaaaa tcaaagtaaa atactacttt ccactcatta gactaaaatc 30781 cattcaagtc tgataatacc tagtactgag ttggagtaat agaaactgct aatgggacag 30841 ttagttggtc atcactttgg agagaaatta gtcagtatct agtaaaagtt agtgatacac 30901 cttccatttt catctgttct gtgctgctac caaagaatac ctgagactag gtaatttata 30961 aataatagaa atgtatttct aatggttcta gaggctgaga agtccaagat tgaagggcca 31021 gcctctgcag agagccttct tgctgtgtca tgccatggca gaagggcaaa gagagggcaa 31081 gagagagcaa aagcaaattc acagcatcaa tcccttttat aatcagcatt actctattaa 31141 tgagggcaag accctcatgg cctaatcacc tctaaaaggt cacacctctt aatactattg 31201 caatggtaat taagtttcta atacatactt tttgggagac attttcaaac tatagcacct 31261 accctatagc ccaacatttc tactcctagg agtatgccct agagaaattc tgcataaata 31321 tctaaagaga ggccattgtt gcattgttag gtactggaaa attggaatca attactatgt 31381 ctaccagcag cagaagatgg ctttttaaaa gttttggttt attcatgaaa tggaatattg 31441 cataaagtat gctccatctc accagatgaa aacatttttc actaggacta tttcaaaagt 31501 agtcttatca ctgggcttct ctattatgca taaaaatttt aagtgaacat gttctttgac 31561 ctagtactcc tacttttagg aatttgccca aaagggacaa ttatactact gggataaatc 31621 tttgaatcat aaagtaagtt gtaaatggta caagcagtat gtcttatttt tatttaaagc 31681 acattaacaa tattacacat atagtaaaaa ataaataaat aaaacatgtg aataataaac 31741 acccaattta gaacaagtgt tgacagtgga gagggaaaga gagagaaaga aggagaaatg 31801 gggagtggga gcgggtacac aaggaaattt tagttgcagc tccaaatttt tactttttac 31861 acaatgaagc gaatatggca aaataagatt tgttaaagtt gggcagcagg tacacagata 31921 ttctatcatt atcctttgaa tatttctgta gatttaagtt gtccattaaa aaaataaaat 31981 acacacataa tttttaagat tagttttttc tatttcctgg ccttcgcatg cactgttaac 32041 tttacctgga attctttatg cagtaattaa gagcaaaggt gtagagcaag actgcttgag 32101 cttggatccc agcactgagt tgatttaggg agaataactt aatctcttaa tcccaagaga 32161 aaatatgata taatagtttt gagctcataa agttttcata agcattaaat gtgacctata 32221 tatgtaaagc aatctaacag tgcctatagt atttataagt gtctgcatta ccaaattcat 32281 cattatcatg gcatgtcatg tcaccatcca ctacattacc atcactgtca ccatcatcat 32341 catcaccacc accatcatca ttaactccct ttgtctagtc aattcatatt tgttcttcgt 32401 attttagata cctgttaaaa tattttttca aagatgtcta ctctgattct tcagtacaaa 32461 tttgatttaa taagatccta tcattttgtc caaatactta taaaaatttg tagttctata 32521 tttaatgtgt tttgtttgtt taacatctct ctcctacatt gtgttaagtt ttttaaagag 32581 aaggtaaggg ttaaagagag acatagagag agaaagagag acagagagag agagagagcg 32641 gttctacagc aatacaggta tattagaaaa acctgcaaag gtggggacca gcttaatgcc 32701 agagcccccc actgcttata ggctggggta cttataggtc tgggggtact tataggcctg 32761 ggtgggtggg gtctgagcag tatggcttgc tgcccaagaa gatgttgata agacgttccc 32821 atgatgaggc agtttggtcc ttgcttccat agagtgtgat gcttcttgca ctttttccca 32881 gcagaatgtg gtagggatgt tccttcaggt gggcctttgc ctggcagggt atgataagga 32941 tgttcctgtg ccttggaatc aggtagttag acaggatgtt tctcacagcc tgaaccccca 33001 tggaatgttt cactttgacc agggtctgcg aaatagcagg gggcttacaa aatggtgtag 33061 tttggactaa caccttggaa cacaaaagtt tcttggggcc aaggctggcg tattagtctg 33121 ttttcatgct gctagtaaag acatacctga gactgggtaa tttataaaga gaaaagaggt 33181 ttaatggact cacaattcca catggctgga ggcctcacaa tcatgaggga ggcaaaggag 33241 gagcaaaggc acgtcttaca tggtggtagg caagagaacg tgtgcagggg aactgccctt 33301 tataaaacca tcagatcttg tgatacttat tcactatcaa aagaacagca cgggaaaaat 33361 ctgcctccat gattcaatta cctcccacca gattcctccc atgacatgtg gtaattatgg 33421 gaactacaat tcaagatgaa atttgggtgg ggacacagtc aaaccatatc agctgggtat 33481 gttttattca cctttttata cccattgtca tgtcttctgg acaaacaatg gatgtaaaat 33541 ggtatagact cctgagtact catttgttga atgacaaatc tatgaaccat ttgaccagta 33601 tgcagcagcc attaaaatta tgtttatgaa taatttacag catggaaaaa tttggggttg 33661 ctagtagaaa aacaaaaagg tacaaaagga tatatataat aagcctacaa tgccatataa 33721 acaatactaa cagcaaaaac aaacctataa attgggggaa gatggggcag atagaagtaa 33781 cctaaaatac taacatgttg ttttggggtc atgaaattat aaatgattat gcacccctta WO 00/09525 PCTIUS99/17712 EPI-109 1114 33841 atttttactt tctatgtttg atttttctat ggtaaatgca tttttattga ggtggaattc 33901 acataacatg aaatgaaaaa tttagtggca tttattatat tcacaatatt gtacaaccac 33961 tagctctact tccaaaacat tttcatcact ccaaaataaa accttgtacc cattaagcag 34021 ttactcccca ttatttcctc tcttagctcc tagcaaccac caacctgctt tctgtctcta 34081 gggatttatt tattctggat attccataaa aatggaggca caatatgtac cttttatgtc 34141 tggcttcttt caccaagcat gtttttgagg ctaatccaca ttgcagcatg tatcagtact 34201 tcatttcttt ttatgaataa ctgtatacag accacaattt gttatccatt ttttggttta 34261 tggacatttg ggttgtttcc atctctcaac tattgtgaat agtgctgcta tgtatatttg 34321 tgtacaagaa tttggtacc tattttcaat tcttttatgt atatatctaa gatgaaattg 34381 cagggttata tgctaatcct atgtttagca ttttttttta ggaaccatta aactgttttc 34441 caaatctgat gccccatttt atattcctac tagcaatgta agcaagttcc aatttctcca 34501 tatcctcaac aacacttgtt attttctatt tttgttatag ccattctaat gagtgtaaag 34561 tgatatatca ttgtggtttt ctttgcattt tccttatgaa cattgatgtt gagtaccttt 34621 tcatgtactt tttggtcatt tatatatcat ctttggagaa atgcctcttc gtgtatgttt 34681 tgcccatttt aaaactagat tgtctttgtt gttgacatgc atgcattctt taaatattct 34741 gcatactagg cccttatcag atatatgatt tgcaaatgtt ttttctcatt ttactggctg 34801 tcttttcact ttattgataa tgtcctttga tgcccaaaag ttgtttattt tgatgaagca 34861 tatttatcaa tttatttctt ttattgctca tgcttttgat gtcacctcta agaatttata 34921 accaaatcag aggtaatgaa ggtttacccc tctattttct tctaagagtt ttatagtttt 34981 gactcattta cttaggtcgc tgattcattt ttagttaatt tttgcatatg atgtgaggaa 35041 gaggtccaac tttactcatt tgcatgtgga tattcagctg tgccagcacc atttgtgaag 35101 agtctatcat ctcctcattt aataatagta ttgacacctt tgttgaaagt caattgataa 35161 taaatgtatg agtttatttc tggaatctaa attctattcc attgatctac atgtctatcc 35221 ttgtatcagt atcacactat cttgattact gtagatttgt agtaagtttt gaaactagaa 35281 agtgtgagta ctgcaatatt cttctttttc ttttttaaag attgtcaggg cctcttgcaa 35341 tttaataggg atatgaggat tgacttttct attctacaaa attaaaattt tgttagagat 35401 tgcattgaca ctgtaggtag ctttcagtaa cattgccatc tcaacaattt taagtattct 35461 aatacatgaa tatgagcttt ctttctcttt atttaggtct tctttaattt ctttcagcag 35521 tgttttgtag ttttggggta caagtctttc acctttaaat tttggtgaaa tttattccta 35581 ggtattgcat ttttttatgc tattgtaaat aaaattattt tctcaatttc ctgttggatg 35641 ttcattgcag gtgtatagaa actcaactga ttctttgtgt tgatcttatg ctgagaccag 35701 ctcagttggg gagaccctaa cctagaagca ctagaggaat taaagacaca aacacagaaa 35761 tatagaggtg taaagtggga aatcaggcgt ctcacagcct tcagagctga gagcttcaaa 35821 cagagattta cccacatatt tattaacagc aagccagtca ttagcattgt ttctatagat 35881 attagattaa ctaaaagtat cccttatggg aaacgaaggg aagggctgaa ataaagggat 35941 gggttgggct agttatctgc agcaggagca tgtccttaag tcatagatca ctcatgctat 36001 tgtttgtggt ttaagaatgc ctttaagcgg ttttctgccc tgtgtgggac aggtgttcct 36061 tgccctcatt ccggtaagcc cacaaccttc cagcgtgggc attatggcca tcatgaacat 36121 gtcacggtgc tgcagcggtt tttatggcca gttttggggc cagtttatgg ccagattttg 36181 gggggcctgt tcccaacaat cttatacctt gcaattttgc tgaatttgct tgttaacttt 36241 gatagttttt ttgaggatta tttgggattt tctacatatc atgtcatctg tgaataaaga 36301 tagttttgct tctttctttc tcatttggat gccttttatt tccttttctt gcctaatttc 36361 cctggctaga acttccagta tgatgttgaa taaccatggt gaaatgggca ttcttgtctt 36421 tttcctgatg ttagagagaa atttttcagt ctttaaccat tgagtataat gttagctgtg 36481 ggttttttac aaatatcttt tatcatgttq aggaagttcc ttcctactcc tacttcttgg 36541 agtgtttttg atataaaggg tatttaattt gtcaaatgct ttttctgtgt cagttgagat 36601 tatcatgtga gatttttttt ccttcattct attagtgttg atgttacatt ggttgatttt 36661 ttatgttgta ctacatttgc attctttata taaatttcac ttggtcatgg tgtataaccc 36721 ttttaatatg ccattggatt tagtttgcta gtattttgtt tagagttttt gcatctatat 36781 tcataagcaa tatcagtcca caggtttttt gtggtttatt tgtctggctt tgctataatg 36841 gtaatgctgt cttcttagaa tgaatgaggg agtgttttct cctctttcat tttttaaacg 36901 tttgagaagg agtgatatta atttttcttt aaatgtttgg tagaacttac cagtgaagcc 36961 gtctggttct taacattttt ctgtgttggg aggtttctga ttaccaattt gatctcttta 37021 atttttacag atcttttcag attttctatt tcttcttgag taacttttta gcaatttatg 37081 tattttagaa atttgttcat ttaatctagg ttatttaatt tattggtgtg cattttttca 37141 tagtattatc ttataatctt ttaatttttg taaagttgat aatgtcccca ccttacctga 37201 tcttagttat ttgtgtcttc tctgtattct ttttgtcttc ttcttctgtc ttagcatagc 37261 taaaggtttg tcaactttgt tgatctttta aagagtcaac ttttgctttc agcatgcatt 37321 actttttaaa tagaaatata tacacctaag ttgcattaca aaggagttgt cctccacaca 37381 cttattcttt cccaccatca gaggtttatg gtccccgcaa aagtcaccat cagttgggct 37441 caactccaat cagtcatggt aggtcagggt ccatctcatt gtctccatca ctcatgccca 37501 cccagggtaa gtctaatcat gttcaccaat cagaacctct gccacatcag ctctgtgggt 37561 ttcctctcat gccatctgta ccaacaatga gcacagtctg ggtttcctga tgttttctat 37621 agcatggtgc ccctccctgg gacacctcag aagccacaat gatattcatt aaacttcttc 37681 ctgcaagtac tccctctatt gctccttcta ctcaccaagc ttagtgtcag ggaatatgct 37741 ggtggggagt atgaatctta gcttctcact cccagactcg gctcccaacc tgctgttgcc 37801 aagtcttggg gacatctata aatgccttct aaatacctgt cttggcctat ccccagccac 37861 agattcctcc ctagagcagg ctacctctga ggcatctata ctgagatctt aatcacagag 37921 acatttaaaa catctaggct acaaaagaat tcctactata gggttcaaat gaatttcttt 37981 ccgtcacttg agacagcttt ttagcaagta catgtattaa agattctgat ttcccctttt 38041 ttctcctaca gtttgtttgg cctaaaggta tgacatctaa tctgctgcat ttacactcta 38101 agtcaaaatt accattttgt tcttttaatt tctatttcta atcatacatt cttgtctact 38161 cctggttcat ctggagacaa agttgaactt agaagatgga ggagaaattc ttatctgccc 38221 tctgctagtt gacacttcct ttccaagaat catttgcagt tgctgggctt tcttgctgtg 38281 actctatgcc ctgttgtgtt actttttcat ttgtgacaaa aacagtggta atagtttgct WO 00/09525 PCT/US99/17712 EPI-109 1115 38341 tcatttttat tatgaagact tgaccaggat aggtaggaac ataatractg ctttttctgt 38401 gggcatcata ttggtccaga tcatgtttaa ccagaattga agatgtaaaa tcctagaact 38461 cactaatcta ttttagtagg tcacaggaag catgcaaacc ataaaaaccg caatgaacca 38521 aaagcatctg tgttgacaag aggcaagaat ttctctattt tctaaaggca ctaactgaac 38581 aaatctattg cccattactt aggaaattgc taagggcatc gttaaagtac ttcaggctgt 38641 tgaaaaacct tttctgtctt cttgccccac caccaattct ctctagctat gctttctctc 38701 acatgttctt gccatccatg gagtggcaga gaggttctga gtacaactct aactttcagt 38761 ttcaatggcc taatccccaa ctcaactgct gaccttgagt gtaaaaataa acaagatctt 38821 aaacatctta gggccagcat tctgggtctt cttttgttat ttggggagca taaactattc 38881 tcatatcatt ggcttgcaga aaaattgagc ttctcctctt ccttgcccca tgtcaccttg 38941 aggtgaccac agccctgcct tctatgtaat cctgcttggt cagcaggcac atcagagctc 39001 agtggcttgt gacatacttt ccttcaagcc tgctcgaagg gccatactca tcattgagac 39061 tgggaacctt agaaaccatg aacccagtgc caatgggtag atacagaatt ctcaaactca 39121 tgaaaaaaca tcctttttaa ctctctccgt gtgcataaag aattctaaga tgtactgatc 39181 aagattccca attttctaac tatctattaa tatatggacg aggtaagaag aaagttgcaa 39241 gaaaaaaatt tgtttgactt gacggttgtg tggttatttg ccacactccc ccagatccac 39301 tctgagtccc aggatgctga ttttaggggc tacattgcct agactgtcca ttattccctc 39361 ttcccatctg gttcagtcac tgggaagcac tggtaggagg tcagagtggg agaaggaggt 39421 taggatactt tctgcccctg ctgtcctact gctttgctga acttctagca gtggctgagc 39481 catcaacctg cagctctcaa ttccagctgt ctgtagcact caagtggtat tgtttattct 39541 tttgatcctt ctagctgtta aggaagaaaa aaataatttt ttcctcaatg ctcataagtt 39601 cttggaatgg acccctgtaa caaaagacag attaacacga gaaaagttta ttaacgtaca 39661 tattttatac gtacatagga gctatccagg gaatgaataa ttcttaaaaa ggtgactttg 39721 aattccagct catatagcat cttcaacaaa gttcagtaac attttagaga tatgacaaga 39781 caaagaaaat gaactttgag cctctaggga cagtgacttg taggaaggca aaaggaataa 39841 atggaggtaa aggctggtta gtaatacttg ttaatgaaga ttcctctggt gccatctcca 39901 ggtccacaag gatttaaatt tgtcttcagt ggtgaacctt tgttcaccct ggcagaaggt 39961 gtggaggggg gtgcagatcc gttttgtctt tgtaagtcta tatcctgctt ttagacaaat 40021 aaagggaggg aaaagagctt tccttcatct gcttcttaat tgccttcagc tcaacaatcc 40081 ttatgcaaaa gaggtacatt ttagggtgtc aaattctggt ctcccacaaa gcatagggat 40141 gacagaccac ctcaccatcc ctgttgcttc ttttaagcct gctcacccct ccaaaaatat 40201 tttcattcta tactgtctct tcaaaatctc agcggagggt gccctctgtt atcctgccct 40261 ctgtgtcagt ataagccaaa ggtttgaatc ctggctctgc aactatctac ctctgtgcct 40321 ctccttgttt atgaaattac agggctggag acaaagatca caatgtgaag acaaaattgg 40381 agagcggtcc taatcagcca gagcaaaatt tctggctctt gctcttcccc atcctgggtt 40441 gaatcatagg aacaggtggc aagatgccag ggtcaggaga ttccagaagt ggcagcaagc 40501 tcagtgttac caggtcaggg atgacctgtc ttattattga aatctcagag atatgctcca 40561 attccggccc agagacacat tgagagacaa ctggggaact tgctatgttc ctgaacaggc 40621 aatgagctgt cttccaagaa aaaacctgag acccttcaag tctcaggtct tacttagcac 40681 atataccagg tcttacacag gacacatggt tacaactgac tgaaatctgg gctgggtgta 40741 ggagctcaca cctgtaatcc cagcccttca ggaggctgag gcaggcagat tgcctgagcc 40801 caggagttcg agaccagccc gggcaacatg acaaaacccc atctctacaa aaaatagtca 40861 ggcatggtgg catgcacctg tagtctcagc tacttgggag gctgagatga gaggattgct 40921 tgaggttgag actgcagtga agcatgatca tgccaccgca ctccagccta ggcaacagag 40981 caagatcttg tcgcaaaaga aagcaaaaac acaacataac acaacaacaa caacaacaac 41041 aacaacagca aaaaagccaa cttcttgaaa tctggaaagg acacctggac tgccctgagc 41101 atttgattgt tgttggctct agcagtggat gcatccttca acctctggca ctctgcaggg 41161 ctcagactgt tctgttctgt ttgttacctg tggagtgcct gccagaccct gctctagctg 41221 ctttaggtcc atttaccctc atagaccccc agtcttgtta ttcatatttc atatttggga 41281 aatggaaact tagaaacttg ccaagtccac agcatgagat cctgcctccg gtgtctgctg 41341 gattccagaa agtgccaggg gccaacttag atgacaccat gttctctgca caatcttagg 41401 aatgctccta gtctgatgtc cccattgcaa aatttacatt atcttttaac aaaacgtctt 41461 tccaaggagg ggcatttaaa ataactgagg ttcttcttgc taaggacgtt cctgacacaa 41521 gagataattt agcatttcct tttcattaaa aagtttgaaa tcctgtaatt tgtgataatg 41581 tggatgaacc tagaggatgt taagtgaaat aagccacaca cagatagaca aataccacgt 41641 gatctcactc ttatgtggaa ttttttttta aataagttgc ttagccgggc atgatggcac 41701 acacctgtaa tcctagctac tcaggaggct gaggtgggag gatggcttga actcagaagg 41761 tggaggtagc agtgagctga gactgtgcca gtgcactccg gtctgggiga cagaatgaaa 41821 cccaatttaa aaaaaaaaaa aaagttgcta tcttagaaaa agacagtaga gcagtggtta 41881 ccagagactg gggaggaaag agaggaggtg agaatgggca gcagttgatc aacgggtaca 41941 aagttaccat gagataggag aaacaagtgc tggtgctctg ctccaagtag ggtgacggta 42001 gttaataatg aattctgtat atataaatag ctagaagaga gggttttcaa tatcattatt 42061 atttcaaaag aaatgataaa tgtttcagag gatggatatg taattaccct gatttgatca 42121 ttgcacaatg tatacatgta gcaaaacatc acattgtgtc ccataaatat atacaattat 42181 tatgtgaatt aaataaaaaa aaattttaaa gtcttatcta aatgaaattt ctaaccagat 42241 tctgaatcca tgataccact gaaaccagca cacatgatcg cagtaaaacc toattatact 42301 tcctccacta tcaccaatac cctttattct ctggaacatg aaacattctg ttgtgctcat 42361 atcatgcaaa ttatcactag taggagagca gagagtggaa atgttccagg tataaagacc 42421 cacaagataa agaagctcag agtcgttaga aacaggagca gatgtacagg gtttgcctga 42481 ctcacactca aggttgcata agcaagattt caaaattaat cctattctgg agacctcaac 42541 ccaatgtaca atgttcctga ctggaaaaga agaactatat ttttctgatt ttttttttca 42601 aatctttacc attagtgcc ctgtatctcc gccttcactt tctgcaggaa actttatttc 42661 ctacttctgc atgccaagtt tctacctcta gatctgtttg gttcaatgc tgagaagcct 42721 gacataccag gactgcctga gacaagccac aagctggtga gttgtaggca ttttttccat 42781 tactttctga ctcataggct caacgcacc caaagctgga aatgccgggt ctgggtacac WO 00/09525 PCTIUS99/17712 EPI-109 1116 42841 cctggggaac tgcaaagcct gcacacttgg gggaaatgat caagazaaa ggcaggggtg 42901 gggatggcat gtgcaccagg agatgttaga gaaaccctga ggaagaucag cgtgcagcag 42961 gtgatggggg agagtgggca gcaagcgagg ccaggacagc cactctgctc agtcaccagt 43021 ccacacaccc aggggctcac tctgcccctc tgagcaccca aggacgzaa agagctggaa 43081 ctgttagtct aaatatagga ccatccaagc tctgaaccaa aatgtgtccc ttgcctcaac 43141 tcaggagatc cacagaggca gaagtaagga atttattttc tgaaagazag atttctatca 43201 gttctgggtg acatgttctg acacttgaaa tgacacctag gacagcacat ttcaggcatc 43261 ttgctcattg ttcactgtag tagaagctac atgctagcca gttgtaaaaa tgaaattaag 43321 taatgtgtgc acagcattta acatagcatc tgagcttcag gagcaczcaa ttaatgacca 43381 cagttgtgat tctttaggca gatgcatttt tttccaactt tgatcagagg tcttatttag 43441 cttctccaga tttcaagaat ctggctcagt gatatgaaat acaagacztg tgaaaagtgt 43501 caattgcaag agaaatggaa ggataaagta tacaggtggg tggaaaaaaa attcacagtc 43561 actgccagaa aaaaaattct tgagaatcaa gtcctgatga tgttagggct tatagttctt 43621 attataaaga gttttatgta ctcattcagt gaacatttat tggtgcczcc tttagccagg 43681 tactatcata agagctgaaa ataaaagcat aatccagtcc ttgatctga ggaacatgct 43741 gtgtgtagca gataacataa taagtgctta tctagatgca tgcagtgtta tgtgataaga 43801 gtaatatgac agaggataca gattaggctt cacagagaag ggggatzga gcaggaggta 43861 ttgaagggtg aatagaagct caccaatcat tttgggcaga ggggcaagga cctgcaaaac 43921 cactgaagca tgaaggaaat ggtgagttta gggaaaatga agagaagatg gctgtgactg 43981 aagcacagga tttgggattg gagaagggac tggaggtgag gctgagaaga ggcaaactca 44041 gaaaagatgt tgtgctgggc agtctggaca ttatctttga agcccaccac atataagtca 44101 tagggctact ggaggtttta agctaaaagt gactattcaa tttcaactta agagaagata 44161 ggttgagagg gaacatggct tgagatgagc catgagcaaa ggaaagacta caacaaagcc 44221 aggagtgagg agtgtgtgaa gcaagaaagt gacagttgaa agcagtgcag aggggatgaa 44281 tctgagaggc atctatgagg tggaactcaa atgacatgat aataatacag ggcatttctc 44341 tgtgtcagat gctgtcctaa gtccttactc cattgatctt cacagcaact cagcatagtt 44401 aatattttat gcataaagaa atcggcactt gaaggagtaa ttggccccag attacactgc 44461 ctataaggat tcaaatccag gtttgtttgg ctccaaaaac tggcccraa ttttcagaag 44521 gagaagcgac ccagggcaat gcccaatttt gcttcttagg caatggagga atccacaatc 44581 ggaaggagtt ttcagcagtg ccccatttgg ggtgggttga atttgaggtc cctgcatgat 44641 acccactttg ctcacttcag tgcctaaaac tgagtatggt tcatagtagg tgttcaataa 44701 gtgttgatgc agtgaataca tgcatgggga gatatgcatc aggcaatggg aaattcaact 44761 ctaaggctta ggggaaagct ggagcttgaa gacagagctt tagaaaacag tagcatagaa 44821 gggagtagga accatgagtt tagacaatac aattcaggaa gaactttgta gcaaggataa 44881 agaggcaaaa aattaaagag gtgagagcta agtgtggtgc ctggggaatc ttaaggtgtg 44941 ggcacgggga ggagatgcca gcaaagaaca tgaataaaaa gcggtagcac agcccctccc 45001 atctggaagc caaaaagaat tgtaaatgga ggaagttagc agaaggatca aatacttgaa 45061 gagggtggaa ttggaataaa accagggcat ttgaaaaatt gggttgtcac tgcaatctta 45121 acaagagaag ttttggcagg atgatggagg cagaaagctg agagaatcat cagttagaac 45181 gtttttgact tcagagaaca gaaaatgcag ttcataatgg ctttaaaaca ggggcttgtt 45241 tttctcccag caatttgaga ggccaaggcg ggtgcatcag gaggtcaaga gaccgagacc 45301 atcctggcca acatggtgaa tccccatctc tactaaaaat acaaaaarta gcggggcatg 45361 gtggtgcacg cctatagtcc catctactca ggaggctgag gcaggagaat cacttgaacc 45421 caggaggtgg aggttgcagt gagctgagat catggccact gcactatagc ctggagacac 45481 agcgagactc cgtctccaaa aaaaaaaaaa aagaaggcag aaggtgaata gttcaagggt 45541 gggtttagga ctcagtgata ataggattct gcctggcttc tcatggtzct ctaggtcttc 45601 cattcatggc accatgccct cactaggcat gctgccagag caggaggggc aggtggaggg 45661 ttctcttgtg tctgtcttat cagggaagaa gagctttctc agaagccccc agcagactcc 45721 cttttcatat tatggtccag caatgagtca cagacctatg caccaccrgc aaaggagcca 45781 gagaaaacaa acgcccagcg cttttagcct gaaaatgaga atctggtttg ctggggaaga 45841 taaagggtgt cggaaaatgg ctgttgggta aatcattgat gtctgccact aggaatgaaa 45901 ggcaaatcag gaactggcac acatgctttc agggagatgg ctgcaaggga gagggcaaag 45961 actgggaagt tgcttatgtg gtgccagact atttggaaga tcatggattg cggtgtttgt 46021 gttgtgtggt catcattttg ttctttgttt acagaacaga gaaagtggat tgaacaagga 46081 cgcatttccc cagtacatcc acaacatgct gtccacatct cgttctcggt ttatcagaaa 46141 taccaacgag agcggtgaag aagtcaccac cttttttgat tatgattacg gtgctccctg 46201 tcataaattt gacgtgaagc aaattggggc ccaactcctg cctccgctct actcgctggt 46261 gttcatcttt ggttttgtgg gcaacatgct ggtcgtcctc atcttaataa actgcaaaaa 46321 gctgaagtgc ttgactgaca tttacctgct caacctggcc atctctgatc tgctttttct 46381 tattactctc ccattgtggg ctcactctgc tgcaaatgag tgggtctttg ggaatgcaat 46441 gtgcaaatta ttcacagggc tgtatcacat cggttatttt ggcggaatct tcttcatcat 46501 cctcctgaca atcgatagat acctggctat tgtccatgct gtgtttgctt taaaagccag 46561 gacggtcacc tttggggtgg tgacaagtgt gatcacctgg ttggtggctg tgtttgcttc 46621 tgtcccagga atcatcttta ctaaatgcca gaaagaagat tctgtttatg tctgtggccc 46681 ttattttcca cgaggatgga ataatttcca cacaataatg aggaacattt tggggctggt 46741 cctgccgctg ctcatcatgg tcatctgcta ctcgggaatc ctgaaaaccc tgcttcggtg 46801 tcgaaacgag aagaagaggc atagggcagt gagagtcatc ttcaccatca tgattgttta 46861 ctttctcttc tggactccct ataacattgt cattctcctg aacaccttcc aggaattctt 46921 cggcctgagt aactgtgaaa gcaccagtca actggaccaa gccacgcagg tgacagagac 46981 tcttgggatg actcactgct gcatcaatcc catcatctat gccttcgttg gggagaagtt 47041 cagaaggtat ctctcggtgt tcttccgaaa gcacatcacc aagcgcttct gcaaacaatg 47101 tccagttttc tacagggaga cagtggatgg agtgacttca acaaacacgc cttccactgg 47161 ggagcaggaa gtctcggctg gtttataaaa cgaggagcag tttgattgtt gtttataaag 47221 ggagataaca atctgtatat aacaacaaac ttcaagggt tgttgaacaa tagaaacctg 47281 taaagcaggt gcccaggaac ctcagggctg gtgtactaa tacagactat gtcacccaat WO 00/09525 PCT/US99/17712 EPI-109 1117 47341 gcatatccaa catgtgctca gggaataatc cagaaaaact gtgggtagag actttgactc 47401 tccagaaagc tcatctcagc tcctgaaaaa tgcctcatta ccttgtgcta atcctctttt 47461 tctagtcttc ataatttctt cactcaatct ctgattctgt caatgtcttg aaatcaaggg 47521 ccagctggag gtgaagaaga gaatgtgaca ggcacagatg aatgggagtg agggatagtg 47581 gggtcagggc tgagaggaga aggagggaga catgagcatg gctgagcctg gacaaagaca 47641 aaggtgagca aagggctcac gcattcagcc aggagatgat actggtcctt agccccatct 47701 gccacgtgta tttaaccctg aagggttcac caggtcaggg agagtttggg aactgcaata 47761 acctgggagt tttggtggag tccgatgatt ctcttttgca taagtgcatg acatattttt 47821 gctttattac agtttatcta tggcacccat gcaccttaca tttgaaatct atgaaatatc 47881 atgctccatt gttcagatgc ttcttaggcc acatccccct gtctaaaaat tcagaaaatt 47941 tttgtttata aaagatgcat tatctatgat atgctaatat atgtatatgc aatatatata 48001 ggctcttgct tgatctctcc aggaggtagt gattatgaga agggggtgga gaatgatgag 48061 ttccttcacc aggagcaaag gacggggatc gtgtggaacc actgcagaac tatttccgga 48121 atcaactaag tggagagagc caggaaggct gcatcagaac ccagtaaagc ttcttgtctg 48181 gatctgagct ggtttgtttt gtgcttgctt ttccctgcct tgccactccc ctcactcttc 48241 tcttttcccc acagcctttt tcacatagct cttggctgta ggattgcccc actccaaaaa 48301 ccagtgtgtg gaggtccagg agtgagacca ggaaagaatg tgaaagtgac tacacaagga 48361 ctcctcgatg gtcgtggaaa aggaaagtca attggcagag cccctgaagc cagtcttcag 48421 gacaaagaag gagcctagag acagaaatga cagatctctg ctttggaaat cacacgtctg 48481 gcttcacaga tgtgtgattc acagtgtgaa tcttggtgtc tacgttacca ggcaggaagg 48541 ctgagaggag agagactcca gctgggttgg aaaacagtat tttccaaact accttccagt 48601 tcctcatttt tgaatacagg catagagttc agactttttt taaatagtaa aaataaaatt 48661 aaagctgaaa actgcaactt gtaaatgtgg taaagagtta gtttgagtta ctatcatgtc 48721 aaacgtgaaa atgctgtatt agtcacagag ataattctag ctttgagctt aagaattttg 48781 agcaggtggt atgtttggga gactgctgag tcaacccaat agttgttgat tggcaggagt 48841 tggaagtgtg tgatctgtgg gcacattagc ctatgtgcat gcagcatcta agtaatgatg 48901 tcgtttgaat cacagtatac gctccatcgc tgtcatctca gctggatctc cattctctca 48961 ggcttgctgc caaaagcctt ttgtgttttg ttttgtatca ttatgaagtc atgcgtttaa 49021 tcacattcga gtgtttcagt gcttcgcaga tgtccttgat gctcatattg ttccctattt 49081 tgccagtggg aactcctaaa tcaaattggc ttctaatcaa agcttttaaa ccctattggt 49141 aaagaatgga aggtggagaa gctccctgaa gtaagcaaag actttcctct tagtcgagcc 49201 aagttaagaa tgttcttatg ttgcccagtg tgtttctgat ctgatgcaag caagaaacac 49261 tgggcttcta gaaccaggca acttgggaac tagactccca agctggacta tggctctact 49321 ttcaggccac atggctaaag aaggtttcag aaagaagtgg ggacagagca gaactttcac 49381 cttcatatat ttgtatgatc ctaatgaatg cataaaatgt taagttgatg gtgatgaaat 49441 gtaaatactg tttttaacaa ctatgatttg gaaaataaat caatgctata actatgttga 49501 taaaagattt aaaaacaact ggctgttttt ttacactgtg gtgtggaaga ttgtgttgtg 49561 ttcacaactt ttcacttctt cccctgtgtg attacacaca cctgcccttg tggtgtgact 49621 tgcagtgcgc cctacaggcc acacaacccc atgccctcca ccactggctc tgctgctgga 49681 atgtgagcag aagtgacatc tgcctcatcc aagcagagcc tcttgctcag ccacaggaag 49741 gcccattcca gatcacaccc gtcagcccgt gcgccctggt gaatgagaag acacagggag 49801 ctgcagccac atataacatg agcaagaagt ctgtgtttgc tgtgataagc cactgagttt 49861 taggggttgt ttgttaagaa gcacaaaaac cgattaagac atgtggtata tagtgacttc 49921 atatatagaa tctggaaaac tatccattta ttttcaatca tggaattcaa tatgacaagc 49981 atcccggagg gtctacctat gccagactgg gttggaaaca gaaagacaga tgttaatgcc 50041 agtgtccttt acacctccaa gtccagggcc agctgtggag tgggaggggt agagaaggtc 50101 ctgtgcacag tcacagtgcg ctgtgcagag caggaacaga ggcatctgtg aaaagtgctg 50161 agagcctgga ggacagagtg actaatgcaa tgacagtctt gcatcatagg aataacagcc 50221 acagcaggat tttattgctg ccaaagaaac tgccatttaa aaattgccag ccatccggga 50281 ggctgaggca ggagaatggc atgaatccag gaggcggagc ttgcagtgag ccgagatcgg 50341 gccactgcac tccagcctgg gcaacagagc cagactccat ctcaaaaaaa aaaaaaaatg 50401 ccagccatct ctctttctaa agtggaatcc tcaagtctcg tttattctgg ggacatttga 50461 gtaggctgtt cgagttaagc aggtggaagt tgatgatccc tcatcatcat tctgagggat 50521 gagtgtctga agactttttg gtaaggaagg gtcttggcat agcccacccc atgccacctc 50581 ccttgatctg tgatatcccc agcagctggg gaggttggag cattttgcaa agaggccccg 50641 aagcctccag aaagtaaacc ttcaagagcc catccttcct tcctcttttg tttttgctca 50701 ttatgaaaac ttccctgaca aattgaaaag gcttcaggtg agattagccc acaggaaaaa 50761 ccaccaaggg ccacccagag gggccacact gtgacagaag gagtatgggc tggtgagctg 50821 acctctggaa gacagtgcat gaattgagga gaagagattg gttccaggca tgggaggaat 50881 gaggctggaa atttcttcag acattgccac ttcggcactc tgtgtgtgtg tgtgtgtgtg 50941 tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtaaacaga gtcctgtaat gcaaggtccg 51001 gccttggcag ccccagcctg gagccacagt gagatgtgag ctgagggtta tgctgggaaa 51061 aacctctccc tcccagcacc tgaaaggctc tgcaggccca gcagctcagc aagcaagggt 51121 aagggcatgg actaacatct tatttcatac tatcccttat aacacatcct aatgtaatca 51181 gctcacaata tgaaattatt tcatttctct ccagtcattg tttcaatggg gccttagggt 51241 tgactggatt ctggaggtcc ctgcctagag gagggggtgc attctgtccc tatgtcccct 51301 cctgctccat cctccacagc acgtgcctag tggtctacct tgtggggaat tcttgtacct 51361 ccctcttcta ggcatggact agcattgaga agtgggagag gagtgttagg aaaaagggca 51421 aatatagaca taccttgtct tattgtgctt tacagatatt gtttttgttg ttgttgttgt 51481 tgtttacaaa ttgaaggttt gtggcaaccc tgcctcgagc aagtctattg gtgctgtttt 51541 tccaacagca tgtgcttgtt ttacatctct gtgtcacatt ttggtaattc tcccaatatt 51601 tcaaactttg tcattatttc tatatctgtt atggtaatct gtgatcagtg atctttgatg 51661 tcactattgt agttgttttg gggcaccatg aagtgcaccc atgtaagatg gcaaacaatc 51721 aataaatgtt gtgtgtgttc tgactgctcc atggactgcc tgttcctgag acacaataat 51781 gtatatataa caattatata tatatatatt tataacaatt atatatatat atattttttt WO 00/09525 PCT/US99/17712 EPI-109 1118 51841 ttttttt-tg aggcaaatc gcactctgat tgcccaggct ggagtgcaat gatgtgattt 51901 cagctcactg caacctc:gc ctccccaggc tcaggtgatt ctcccacttc agcctcccaa 51961 gctgggacta caggtgtgca ccatcacacc cggctaattt tttttttgta tttttaggag 52021 agacagggtt ttgccatatt gcccaggctg gccttaaact cctagactca aacaatccac 52081 ctgcctcagc ttcccaaagg gctgggatta caggcatgag ccactgtgcc cagcccaaga 52141 cacaataata ttgaaattaa gccaattaat aaccctacaa tggcctctaa gtgttcaagt 52201 gaagggaaaa gtcccacgtc tctcacttta aatcaaaatc tagaaatgat taagcttagt 52261 aaggaggaca tattgaaagt caaggccaaa agctcacctc tgcaccagtt agccaaattg 52321 cgacttcaca ggaaaagttc ttgaaggata tttaagctct actccaggga acatgcaaat 52381 gaagagaaaa caaagcaacc atattgctaa tatggagaaa gtttgagtgg tctggagaaa 52441 agatccaacc agccacaaca tttccttaaq tcaaagccta atccagagca agactctaac 52501 tctcttcaat gctatgaagg cggagagagg tgaggaagct gcagaagaaa agtttgaagc 52561 tagcggaggt tgqtttgtga ggtttaatga aagacaacat ctccataaca taaaaatgca 52621 agatgaagca gcaagtgcaa aqggagaagc tgtggcaagt tatccagaaa atctagataa 52681 gataattgat gaaagtgtct acacgaaaca acagattttc agtgtagaca aaacagtctt 52741 atgttggaag aagatgccat ccaggacttt cacagctaga gaggagatgt caaggcaagc 52801 tgcaaagctc cacaggacag gctgactctc tttttagagg tgaatgcagc tgatgacttt 52861 aagttgaagt aaatgttcat ttactatttt gtaaatcctg gtgtcattaa gaattatgcg 52921 aaatctactc tatctgtgct ccataaatgg aacaataaag cctggatgac aacacatctg 52981 tttacagcat ggtttactga atatttcaag cccactattg agaactattg ctcagaaaaa 53041 aagattcctt tcaaaatatt actgctctgc accatgtcga tcaagagctg tgttggagat 53101 gtacgagaat attcatgttg ttttcatccc tgctaacaca aacatccatt ctgcagtcca 53161 tggaccaaga ctttcaagtc ttattaagaa atatatttca taaggctatt aagaaatagc 53221 tatatatata tatatatata gccttatata gtttatatag ctaccattga tagtgattcc 53281 attgatggat ctgagcaaag caaattgaaa agcttctgga aagtagtcat tattctagat 53341 gccattagga acatttgtaa ttcatgggag gaggtcaaaa taccaacatt aacaggagtg 53401 tgaaagacat tgattccaac ccccatagat gactttcagg ggttcacgtc ttcagtggag 53461 gaagttgctg tagatgtggt ggaaacagca agagaactag aactagaagt ggagcctgaa 53521 gttgtgactg aattgccgca ctctcatgat caaacttgaa cagatgaaga gttgcttctt 53581 acatatgagc agtgaaagtg gtctcttgag atggaatctc ctcctggtga agatgctgtg 53641 aacacggtta aaatgacaac aatcgattta gaatattaca taaatttagt taataaagca 53701 gtggcagggt ttgagaggat tgactccaat tttgaaagaa gtgggtaaaa tgctatcaaa 53761 tagcatcaca tggtatggag aaatcttttg tgaagggaag agtcgaccaa ggtggcaaat 53821 tgcattgtca tcttatttta agaaattgcc acagccaccc ccagctttag caaccaccac 53881 cctgatcagt aagcagccat caacatcaaa acaagaccgc catcctcttc agcaaaaaca 53941 ctatgacttg ctgaaggctc agatgatggt tagcattttt agcaatacaa tatttttaat 54001 taaggtatgc acattggttt ttctgacata atactattgc atacttaata gactacagta 54061 taggataaac acaactttta tatgcactgg gaaaccaaaa aggttatttt tgagatattt 54121 gctttactgt ggtggtctga agctgaactc acaatctcac caaggtgtgc ctgaacctct 54181 ttagctaact ggccactgcc acagtccact ctgtgttggt caagatgccc cagagtggca 54241 ggcacactgt gtggtcacat ccaagggcct agatatggtg ggggctccaa atggatctag 54301 atatgtgaga tctctctttg atttgacttc ttccaaccca ccattttctg ggtgctgggc 54361 tcatctcacc cagaaagtag gacccaatgt gacagttcct gcccagttcc ctcctgtggt 54421 agccacttga cccaggggca ctcttgatcc ttgcagcctc acttacacac cctatctcta 54481 cccctattaa ctctctccaa tccccactcc ccctgctcag cttgtctgct gcccagtggg 54541 ggccccaccc atgctggcct ctccttttgc aagtccccat tcctcatatg gtttcttcag 54601 agccccttc tttggctttg aggagagatg ccctcactcg cttccccacc aatcctgccc 54661 acttctacaa tccattcatt atcctaattg cctccgtata cagactggag tgagaggagt 54721 tgatgtgatg ggtgtggata cagggctggt gctgtcatct tctagtaagc cctgggagag 54781 gtgtctgagc ccaggtgtca gtggttttct ttggaactgt gagtgcataa cacttctttg 54841 ccttcagcct taggccatag ttgctagttc tgggacaacc agaaaagccc tacataatct 54901 cgtgttatgt gcagagctga gtatagagct ccaggtatga tctgactcac ttaagatcac 54961 agtgagtcta ttgtattgtt gaactgttag cttagacatc tgttactgta cctacatggc 55021 actagcctca cgcctagaca ccgatctgaa agaaatcccc taaatgcata gagaagactt 55081 ctcagctgag ctaaggggct cccaccaggt ttgagcctat ctaatgaatc catgaggtag 55141 acagcctgca catgtccact tggtttgatg aattgcacaa atccctatgg gggatgtggt 55201 tcatgggctg ggaagtgggt taccctggga aaggtctaca ggacagaggc agggatggag 55261 acaacagcat ggtgagttcc caacccaccc acgatgatag gtgtctgagg cagaaggtaa 55321 agaggctgtc acctggtggg tgtcataaga ctcaagtgtc attgttgagg cacatgggta 55381 acaaagcgtg gcactggatg ggggtagatt cttcctattt ctgtgaggat cagggggact 55441 ccctggctct cctgctaaag gtggctctag ggacaggaag agtgtacttc ttgacaggga 55501 tgtcagagca ctgatggtga caatcagtgt gacactgctc acatgactga acaaccgaga 55561 agagcccgac tgtctactga acaacgggaa gagcccgact gtcaatgacg gagctctgtt 55621 aaatatagtt aaggctattt tgttgaatga atgaagccag acaggaaaga ggacagtatc 55681 tttaatccat ttatagaagt taaagacagg cttatttaat ctctatgaag acagagtggc 55741 ccttacctct gggtggagca aaaggcacct tctgaagtga tagggatgtt ccttatcatc 55801 ttgatccgga gtggtagtta catgcatgta tgcatatcaa aactcaccaa gctgtaccac 55861 taagtgtgtt cttcctcaat aaaaataata aagaactaca cttataaaga attttttaat 55921 aatataggaa aatgtctaca ctataatctt tagctaaaaa aaaaaaaaaa gaagccgcct 55981 acagaatggt atatgcatga gaacaattaa tcgaaaagtg catgggaaaa gtcaggattg 56041 aaacatcatg ttttaaaaga cattgttttg atactgtgag aatgtaccta agtttttcct 56101 tttttctgtt tttcccaatt ttatacaatg agcatgtgtt ggttttataa ttagacattt 56161 tgtttgtttg gttggtttt gagacacagc ttgctgtcac ccaggtgga gtgcaatggc 56221 ccaatcttgg ttcactgcaa cctccatctc ctgggttcaa gagattctcc cacttcagcc 56281 tcctgagtag cagggactat aggggcgcac caccacatcc agctaatttt gtgtattttt WO 00/09525 PCT/US99/17712 EPI-109 1119 56341 agtagagatg gggtttcacc atgctggcca ggttggtctc aaaczctga cctcaagtta 56401 tccaczcgcc tcggcttccc aaagtgctgg gattataggc atgagccacc gcacttggcc 56461 tagacatttg tttttaaaaa taaaagattc atttgctctt tttacagccc gtctcactgt 56521 tgactgatat tgaccaggag tcaactcagg ccccagggat tttcacaaca gctgctgtat 56581 ggcagggttt ctgctcactg tgctcatgta gttggccctt gcacccaaag tgaataatta 56641 acattctccc catcctgttg acgatgctct gaaaatatgg tccagaaatg gtgtgagcaa 56701 ggagacagca aagcaatgct tggaacatag gtgcagtgac tagacarggg gcagctgttt 56761 aaagacaaaa aggccccaaa aaggagggat ggcacgaaac accctccaat atgggcatgg 56821 agtctagagt gacaaagtga tcaaaagttc atttcctatg gggtg-ccga atgtacttaa 56881 taataaaaag agaacaagag ccatgcaaac tgagagggac aaagcagaaa gagtagcaga 56941 caccaagcaa ctaagtcaca gcatgataag ctgctagctt gttgtcatta ttgtatccag 57001 aacaacattt catttaaatg ctgaagaatt tcccatgggt ccccac-ttc ttgtgaatcc 57061 ttgggctgaa cccccctgtc ctgagtggtt actagaacac acctczggac cagaaacaca 57121 aaagtggagt aacacacact gcaaagctgt gcttccttgt ttcaucctgt gaatcctcac 57181 cttgtttccc atctagccta tatttttcaa actaacttgg ccatagaatc atgtagtatt 57241 tagggtggaa gctgccccag gtctagcacg tcatttaaca gatgaagaaa tggaagcttg 57301 ggcagtggaa gtatcttgcc gaggtcacac agcaagtcag cagcacagcg tgtgtgactc 57361 cgagcctgct ccgctagccc acattgccct ctgggggtga gtatgtcttc acatcctcca 57421 ataccctaat gacagacaaa cagaacatgg caaagcctca gctctgcatg gtgaaagtaa 57481 gaaccagcaa ttgccacaaa cagaaataca gtgttggtcc ggcagcctcc gggggttctg 57541 cacaagtgga ttaccagtga atacaaggct atctatcttt cgaaaaacca acgttgtatt 57601 tatgctattt tctataaaat tttatattaa tttatttgtt acctattttt gaactctttc 57661 aaaagcacac tttatatttc cctgcttaaa cagtcccccg agggtgggtg cccaaaaggc 57721 tctacacttg ttatcattcc ctctccacca caggcatatt gagtaagttt gtatttgggt 57781 ttttttaaaa cctccactct acagttaaga aaactaaggc acagagcttc aataatttgg 57841 tcagagccaa gtagcagtaa tgaagctgga ggttaaaccc agcaacatga ctgcagttct 57901 taatcaatgc cttttgaatt gcacatatgg gatgaactag aacattttct cgatgattcg 57961 ctgtccttgt tatgattatg ttactgagct ctgttgtagc acagacatat gtccctatat 58021 ggggcggggt tgggggtgtc ttgatcgctg ggctatttct atactattct ggcttttccc 58081 aagcagtcat ttctttctat tctccaagca ccagcaatta gctttacctt ttcagcttct 58141 agtttgctga aactaatctg ctatagacag agactccggt gaaccaattt tattaggatt 58201 tgatcaaata aactctctct gacaaaggac tgctgaaaga gtaactaaga gtttgatgtt 58261 tactgagtgc atagtatgtg ctagatgctg gccgtggatg cctcatagaa tcctcccaac 58321 aactcatgaa atgactactg tcattcagcc caatacccag acgagaaagc tgagggtaag 58381 acaggtttca agcttggcag tctgactaca gaggccactg gcttagcccc tgggttagtc 58441 tgcctctgta ggattggggg cacgtaattt tgctgtttgg ggtctcattt gccttcttag 58501 agatcacaag ccaaagcttt ttattctaga gccaaggtca cggaagccca gagggcatct 58561 tgtggctcgg gagtagctct ctgctgtctt ctcagctctg ctgacaatac ttgagatttt 58621 cagatgtcac caaccaccaa gagagcttga tatgactgta tatagtatag tcataaagaa 58681 cctgaacttg accatatact tatgtcatgt ggaaaatttc tcatagcttc agatagatta 58741 tatctggagt gaagaatcct gccacctatg tatctggcat agtgtgagtc ctcataaatg 58801 cttactggtt tgaagggcaa caaaatagtg aacagagtga aaatccccac taagatcctg 58861 ggtccagaaa aagatgggaa acctgtttag ctcacccgtg agcccatagt taaaactctt 58921 tagacaacag gttttttccg tttacagaga acaataatat tgggtagtga gcatctgtgt 58981 gggggttggg gtgggatagg ggatacgggg agagtggaga aaaaaggggc acagggttaa 59041 tgtgaagtcc aggatccccc tctacattta aagttggttt aagttagctt taattaatag 59101 caactcttaa gataatcaga attttcttaa ccttttagcc ttactg-tga aaagccctgt 59161 gatcttgtac aaatcatttg cttcttggat agtaatttct tttactaaaa tgtgggcttt 59221 tgactagatg aatgtaaatg ttcttctagc tctgatatcc tttattcttt atattttcta 59281 acagattctg tgtagtggga tgagcagaga acaaaaacaa aataazccag tgagaaaagc 59341 ccgtaaataa actttcagac cagagatcta ttctctagct tattttaagc tcaacttaaa 59401 aggaagaact gttctctgat tcttttcgcc ttcaatacac ttaatgattt aactccaccc 59461 tccttcaaaa gaaacagcat ttcctacttt tatactgtct atatgattga tttgcacagc 59521 tcatctggcc agaagagctg agacatccgt tcccctacaa gaaactctcc ccggtaagta 59581 acctctcagc tgcttggcct gttagttagc ttctgagatg agtaaaagac tttacaggaa 59641 acccatagaa gacatttggc aaacaccaag tgctcataca attatcttaa aatataatct 59701 ttaagataag gaaagggtca cagtttggaa tgagtttcag acggttataa catcaaagat 59761 acaaaacatg attgtgagtg aaagacttta aagggagcaa tagtatttta ataactaaca 59821 atccttacct ctcaaaagaa agatttgcag agagatgagt cttagctgaa atcttgaaat 59881 cttatcttct gctaaggaga actaaaccct ctccagtgag atgccttctg aatatgtgcc 59941 cacaagaagt tgtgtctaag tctggttctc ttttttcttt ttcctccaga caagagggaa 60001 gcctaaaaat ggtcaaaatt aatattaaat tacaaacgcc aaataaaatt ttcctctaat 60061 atatcagttt catggcacag ttagtatata attctttatg gttcaaaatt aaaaatgagc 60121 ttttctaggg gcttctctca gctgcctagt ctaaggtgca gggagcttga gactcacagg 60181 gtttaataag agaaaattct cagctagagc agctgaactt aaatagacta ggcaagacag 60241 ctggttataa gactaaacta cccagaatgc atgacattca tctgtggtgg cagacgaaac 60301 attttttatt atattatttc ttgggtatgt atgacaactc ttaattgtgg caactcaaac 60361 tacaaacaca aacttcacag aaaatgtgag gattttacaa ttggctgttg tcatctatga 60421 ccttccctgg gacttgggca cccggccatt tcactctgac tacatcatgt caccaaacat 60481 ctgatggtct tgccttttaa ttctcttttt gaggactgag agggagggta gcatggtagt 60541 taagagtgca ggcttcccgc attcaaaatc ggttgcttac tagctgtgtg gctttgagca 60601 agttactcac cctctctgtg cctcaaggtc cctgtctgca aaaatgaaa aatatttcct 60661 gcctcataag gttgccctaa ggattaaatg aatgaatggg tatgatctt agaacagtga 60721 ctggcacca gtatgagccc tcgaggcctc ttaattata ctggcaagct catagtgcat 60781 gttctttgtg ggctaactct agcgtcaata aaaa tcaa gactaaattg cagctgggca WO 00/09525 PCT/US99/17712 EPI-109 1120 60841 tggtggctca tgcctgtaat cccagcattc taggaggctg aggcagaagg atcgcttgag 60901 cccaggagtt cgagaccagc ctgggcaaca tagtgtgatc ttgtatctat aaaaataaac 60961 aaaattagct tggtgtggtg gcgcctgtag tccccagcca cttggagggg tgaggtgaga 61021 ggattgcttg agcccgggat gatccaggct gcagtgagcc atgatcgtgc cactgcactc 61081 cagcctgggc gacagagtga gaccctgtct cacaacaaca acagcaacaa aaaggctgag 61141 ctgcaccatg cttgacccag tttcttaaaa ttgttgtcaa agcttcattc actccatggt 61201 gctatagagc acaagatttt atttggtgag atggtgcttt catgaattcc cccaacagag 61261 ccaagctctc catctagtgg acagggaagc tagcagcaaa ccttcccttc actacaaaac 61321 ttcattgctt ggccaaaaag agagttaatt caatgtagac atctatgtag gcaattaaaa 61381 acctattgat gtataaaaca gtttgcattc atggagggca actaaataca ttctaggact 61441 ttataaaaga tcacttttta tttatgcaca gggtggaaca agatggatta tcaagtgtca 61501 agtccaatct atgacatcaa ttattataca tcggagccct gccaaaaaat caatgtgaag 61561 caaatcgcag cccgcctcct gcctccgctc tactcactgg tgttcatctt tggttttgtg 61621 ggcaacatgc tggtcatcct catcctgata aactgcaaaa ggctgaagag catgactgac 61681 atctacctgc tcaacctggc catctctgac ctgtttttcc ttcttactgt ccccttctgg 61741 gctcactatg ctgccgccca gtgggacttt ggaaatacaa tgtgtcaact cttgacaggg 61801 ctctatttta taggcttctt ctctggaatc ttcttcatca tcctcctgac aatcgatagg 61861 tacctggctg tcgtccatgc tgtgtttgct ttaaaagcca ggacggtcac ctttggggtg 61921 gtgacaagtg tgatcacttg ggtggtggct gtgtttgcgt ctctcccagg aatcatcttt 61981 accagatctc aaaaagaagg tcttcattac acctgcagct ctcattttcc atacagtcag 62041 tatcaattct ggaagaattt ccagacatta aagatagtca tcttggggct ggtcctgccg 62101 ctgcttgtca tggtcatctg ctactcggga atcctaaaaa ctctgcttcg gtgtcgaaat 62161 gagaagaaga ggcacagggc tgtgaggctt atcttcacca tcatgattgt ttattttctc 62221 ttctgggctc cctacaacat tgcccttctc ctgaacacct tccaggaatt ctttggcctg 62281 aataattgca gtagctctaa caggttggac caagctatgc aggtgacaga gactcttggg 62341 atgacgcact gctgcatcaa ccccatcatc tatgcctttg tcggggagaa gttcagaaac 62401 tacctcttag tcttcttcca aaagcacatt gccaaacgct tctgcaaatg ctgttctatt 62461 ttccagcaag aggctcccga gcgagcaagc tcagtttaca cccgatccac tggggagcag 62521 gaaatatctg tgggcttgtg acacggactc aagtgggctg gtgacccagt cagagttgtg 62581 cacatggctt agttttcata cacagcctgg gctgggggtg gggtgggaga ggtctttttt 62641 aaaaggaagt tactgttata gagggtctaa gattcatcca tttatttggc atctgtttaa 62701 agtagattag atcttttaag cccatcaatt atagaaagcc aaatcaaaat atgttgatga 62761 aaaatagcaa cctttttatc tccccttcac atgcatcaag ttattgacaa actctccctt 62821 cactccgaaa gttccttatg tatatttaaa agaaagcctc agagaattgc tgattcttga 62881 gtttagtgat ctgaacagaa ataccaaaat tatttcagaa atgtacaact ttttacctag 62941 tacaaggcaa catataggtt gtaaatgtgt ttaaaacagg tctttgtctt gctatgggga 63001 gaaaagacat gaatatgatt agtaaagaaa tgacactttt catgtgtgat ttcccctcca 63061 aggtatggtt aataagtttc actgacttag aaccaggcga gagacttgtg gcctgggaga 63121 gctggggaag cttcttaaat gagaaggaat ttgagttgga tcatctattg ctggcaaaga 63181 cagaagcctc actgcaagca ctgcatgggc aagcttggct gtagaaggag acagagctgg 63241 ttgggaagac atggggagga aggacaaggc tagatcatga agaaccttga cggcattgct 63301 ccgtctaagt catgagctga gcagggagat cctggttggt gttgcagaag gtttactctg 63361 tggccaaagg agggtcagga aggatgagca tttagggcaa ggagaccacc aacagccctc 63421 aggtcagggt gaggatggcc tctgctaagc tcaaggcgtg aggatgggaa ggagggaggt 63481 attcgtaagg atgggaagga gggaggtatt cgtgcagcat atgaggatgc agagtcagca 63541 gaactggggt ggatttggtt tggaagtgag ggtcagagag gagtcagaga gaatccctag 63601 tcttcaagca gattggagaa acccttgaaa agacatcaag cacagaagga ggaggaggag 63661 gtttaggtca agaagaagat ggattggtgt aaaaggatgg gtctggtttg cagagcttga 63721 acacagtctc acccagactc caggctgtct ttcactgaat gcttctgact tcatagattt 63781 ccttcccatc ccagctgaaa tactgagggg tctccaggag gagactagat ttatgaatac 63841 acgaggtatg aggtctagga acatacttca gctcacacat gagatctagg tgaggattga 63901 ttacctagta gtcatttcat gggttgttgg gaggattcta tgaggcaacc acaggcagca 63961 tttagcacat actacacatt caataagcat caaactctta gttactcatt cagggatagc 64021 actgagcaaa gcattgagca aaggggtccc atagaggtga gggaagcctg aaaaactaag 64081 atgctgcctg cccagtgcac acaagtgtag gtatcatttt ctgcatttaa ccgtcaatag 64141 gcaaaggggg gaagggacat attcatttgg aaataagctg ccttgagcct taaaacccac 64201 aaaagtacaa tttaccagcc tccgtatttc agactgaatg ggggtggggg gggcgcctta 64261 ggtacttatt ccagatgcct tctccagaca aaccagaagc aacagaaaaa atcgtctctc 64321 cctccctttg aaatgaatat accccttagt gtttgggtat attcatttca aagggagaga 64381 gagaggtttt tttctgttct ttctcatatg attgtgcaca tacttgagac tgttttgaat 64441 ttgggggatg gctaaaacca tcatagtaca ggtaaggtga gggaatagta agtggtgaga 64501 actactcagg gaatgaaggt gtcagaataa taagaggtgc tactgacttt ctcagcctct 64561 gaatatgaac ggtgagcatt gtggctgtca gcaggaagca acgaagggaa atgtctttcc 64621 ttttgctctt aagttgtgga gagtgcaaca gtagcatagg accctaccct ctgggccaag 64681 tcaaagacat tctgacatct tagtatttgc atattcttat gtatgtgaaa gttacaaatt 64741 gcttgaaaga aaatatgcat ctaataaaaa acaccttcta aaataattca ttatattctt 64801 gctctttcag tcaagtgtac atttagagaa tagcacataa aactgccaga gcattttata 64861 agcagctgtt ttcttcctta gtgtgtgtgc atgtgtgtgt gatgtataca aagagagaga 64921 taattgtatt tttgtatttt cttttaaata atttttaaaa ttgacccttt tcctgagaca 64981 aattgccaga atagtttgta tttagagatg gtacctctaa gagtaaggtt gctggttgct 65041 gagcaattga cttgaaaact tttaaaattc aaattttaat tccactactc aaaagaattg 65101 ccatgtttta aaaaagagaa ttggtgccat aagttagttg tctatgtttg aaaatgaaga 65161 agaatgcaa cgtcatggcc tggtcactca cccgcagccc tgagttgtag gcacatcata 65221 tgtgagaactg aggatgcttt tctttcattt aaaatccctc cccaaaactt ggctctaatt 65281 gcagtcatga caatcatgta catttggatt tatgtgcacg agtctcttac cctgagagag WO 00/09525 PCT/US99/17712 EPI-109 1121 65341 gacaggtgct acaggtggag gggacccgtc tgggtcacgt tcacatttta aacatgctgg 65401 ttttcagtca ctgcacactc atctcccagc gcaggtcatg ggcagcagat gcaaaagctg 65461 cccgtggtcc zatttggagg tgcatgaaat gagcagaaga cagaatagct tgatctgact 65521 agaagggcag cttqtcccta ccaagacttg aaggattgcc tttcatctgt tagggtaaaa 65581 ggtagaatga accaaggaag ggcaggaggg ggctggggtt agggtagaag gaaggggcca 65641 tggagaaggg aaatccatcc cataggagga aggcagtgcg gcagggaggt ttgaaggtat 65701 cagcttttgt ggctgacata catgcagtca tgtcaattgc tcgtttttcc ttttccatct 65761 tattaaatgt cttccaatgt tagcacgaag aaaagctatt tgcagtgttg ccagcctttc 65821 cagagcccgt ccccattacc tccccaggcc catgccttta ccctggag tttcaactca 65881 cgaccttcag gatctgactt tattcaccaa ctctggggtg aacgtacctt ctgtctccac 65941 ccagaggtct ctatcaaaga ggagattgca tgccatggat aaagtcaaag tagaggtgac 66001 tgtccttagg aagagtaatg tgaaaattca taaactggga ttctgtttac attttgtact 66061 ccaggggttc ttagtttaaa tcgctctgaa taaattaaga tgcaatggca tttcaactgt 66121 tatgattaaa tttacaaatc atttattttc tatcacgggg agagatagag ctccaaatgc 66181 aaacataact gctcaagtgt taacacttat aatgaaaaca taagaattac caccaactac 66241 cctgggggct agaagcagaa atgtgaacca gaaaacaaat catgaacttt cctttttttt 66301 tttgagatgg agtctcgctc tgttgcccag gctggagtgc aatggtgcga tctcggctca 66361 ctgcaaccac tgcctcccgg gttcaagcaa ttctcctgcc tcagcctcct gagtagctgg 66421 gactacaggc atgcaccacc acgcctgggt aattttttgt atttttagta gagacagggt 66481 ttcaccgtat tagccaggat gctctcgatc tcctgacctc gtgatctgcc cgcctcggcc 66541 tcccaccgaa gtgctgggat tacaggcatg agccactgtg cccggccaac aaatcatgaa 66601 ctttctaact gcagttcctt gtagcttgtt aacacatcca cttacttatt gtcagagtac 66661 gtggagattt tccacaaccc tcggggataa ggctgaacag aagaggcaaa aacgtgaaaa 66721 catttcgata gctcctatac tttgaaataa aattcactgt aaaagttgct tgtatttttc 66781 caaaacagag tcaaccctta atatttaaga ttctgtatac aaatacatat ttttatataa 66841 ttaatatata ttgtcatatg acatatatct ttatattaat atgcatgcat ataatatata 66901 tttccttcct aattttctat aagcaattc acaagactga cttctatttg cctccttatt 66961 gttactacgt ggtttgataa tccgttttgt gtcattgtga ttctgtcatg ttttggggac 67021 ttatttttgt ttctctgggt ggtcactagt ttttttaaag cattcatgga agagtgtgaa 67081 tcttttacaa gctaggaagc catggcaagc cttgggtcat actgcccccg cgaggccaca 67141 ttggcaaacc agcaagggtg ttcaacttcc agacttggcc atggagaaga catacgagga 67201 ggcttttcac attcagctct ttaatgtttg tctctgccgg caccatccca gttgtgaata 67261 agaggtattt ccacagcggc tcagggtagg tagtgcacag ctcacattca tcatttctga 67321 aaaccgagag gagtctccat tcggggtaca ggttgatgcc tgtcgtggaa tgaaggttcc 67381 aacacccaga ccaatctctg cagtgtgctg ctctcatgag cttgcaacaa gatcagaaaa 67441 tgttttgtga ctaagcattt ttcatattgc ataaaatgct tcaagctcct cccttgtttc 67501 tctctataat cctgtatatc tgatgattgt gggtaccaag tgtttgaaat aatcaaatgt 67561 gatttgatgt tggtaaattt cttttttttt ttttttttac ttctattttt tttattatac 67621 tttaagtttt agggtacatg tgcacattgt gcaggttagt tacatatgta tacatgtgcc 67681 atgctggtgc actgcaccca ctaactcgtc atctagcatt aggtatatct cccaatgcta 67741 tccctccccc ctccccccac cccaccacag tccccaaagt gtgatattcc ccttcctatg 67801 tccatgtgat ctcattgttc aattcccacc tatgagtgag aatatgcggt gtttggtttt 67861 ttgttcttgc gatagtttac tgagaatgat ggtttccaat ttcatccatg tccctacaaa 67921 ggacatgaac atagcaaaga cttggaacca acccaaatgt ccaacaatga tagactggat 67981 taagaaaatg tggcacatat acaccatggt aaatttcttt atcattcgca ctctcctttc 68041 tctattattg ttattgtaac tgaaccgcag attagtcact cattgcttgc agaatccaat 68101 taacaagagc gaggtcagat ataaagaaaa tgatttattc caaacctcct tcagggaaga 68161 ggtgcagcct cctgcccca aatgcactgc ttcgccaggc gtggtggctc acacctgtaa 68221 tcccagcact ttgggagacc gaggagggca gatcacttaa ggtcaggagt tcaagaccgg 68281 cctggccaat atagtgaaac ccctgcctct actaaaaata caaaaaatta gccagacgtg 68341 gtggcgggtg cttgtaatcc cagctactcg ggaggctgag gcaggagaat cgcttgaacc 68401 tgggaggtgg aagttgcagt gagctgacat ctagccactg cactccagcc tgggtgacag 68461 agtgagactc tgtctcaaaa taaataaata aataaataaa taaataaata gtaaatgcac 68521 tgctttgctt ttggagcaga aagcaggcac tttgaaaagg caggggagga agtgagcaag 68581 ggcagggggt ctgcacactg gcatggtgcc tgatctatcc aggcagttga attggcactt 68641 tcataggcag aaataagttg aaaaagtggc ctaaaactct ctaggtggga gtggatagtg 68701 ggcatgcctt caacctgcct ttctggaggg tgagttccat ggcaaccccc tgaagggtga 68761 gagttccatg gagatcatgc tttggtctgt aaatcagctg ttaactctct agaaagttct 68821 gtcttggagc atatagttag atgaacttgc cctgtaaaga atgtctggtg aaggggaagt 68881 aaaaggtgag atttgcattt ctaaagggct aagtagaacg tggggtacaa gaggaaagga 68941 gaaaagagaa aataatttaa aaaataattg taacttattc ccttttactt agaaaaaagg 69001 gaatactcag ttacattatc acctcgttta catcaaaccc tcttatggaa tcctatggtt 69061 tgaaaacaaa aaggttgttg aggaccagtg agcccaaccc ctttgcttta taaatgaaga 69121 gcattgcctg ccctaagccc cagagactct gatgtcgtgg gtctggagtg ggctccaaca 69181 gcggcatgtt ttgatggtgc ttcccagtgg cacgccagcg atgagccttt gagtagggaa 69241 agtaggagca ctcgtgactc ccttcacgat cagcacctgt gtgctaataa attcacaaaa 69301 gccaacatat tggagtcact cagggagttt tacaaatagt gaggttaaat ccaacctcaa 69361 atagttctga ttcgatctgc ctgcattgct gccctgtggt tccccactgt agaagctccc 69421 caggtgattc taagtgtagc caagtctgag aaatactgcc taaagcctgt tggactgaca 69481 gcaagggctg ttgtctgagc aagactttgc ctggcctggg gtggcatgtg caccaggaag 69541 agtctcaact ttcataacag aacattcccc aagctggttt ttttaaagca tgtgaatcta 69601 gacttcattg gcaataccaa agatctgtat ttgaggctcc aagtatttca ctttcatttt 69661 tggttttggg ttatgttttc acccttcctt tccaagtgaa aagtaaacag aagtgggatg 69721 tctggcgccc argctgagct tggcaacttc aaattcaata gagaagaagt ctcttgtata 69781 gaaaagggcc tatctgagat gtttctcaaa taaatataga ttttgcttat gtggctaaag WO 00/09525 PCTIUS99/17712 EPI-109 1122 69841 gattcttctc cccccatttc cttatccctg cagtgagcca cccttcttaa ctctttccat 69901 gaaaacatta ttcctgaaga actgggaact catgccagcc ctgatcaggc aatgataatt 69961 ctgcagagaa ttagaattta gatttaaatt gtcaactctt atacatcctg gcatatggtt 70021 taaacacatg tacacacaca caaacacctc ctactattta ctgaagagca gatatctgat 70081 aacttaatct ttcggtttt gagtcaagac aattccccct tttgaaactg cataccgctg 70141 aatataataa aatgtaatta agattaaaaa taagaaacta atgggagaat ttcaatattg 70201 tctctgttca ctttaaaatt cctctactta ggtttactgc cattaccaaa gactattcaa 70261 aaatcctttt taggagaatc ctaatggttt cctgacatat aatcaaataa ggactctgtt 70321 gattggctaa ctcaatcttc ctgtgccaaa aagcagagcc cagcagagaa gagggcaggg 70381 acttgaaagt cagactgact cgagttccag ccttggggct gtgggagctt gggcaagtga 70441 cttaacgtct ctggctctca ggatctaaaa ggatttccag tagtaatttg gggtgttact 70501 gatacaggag ctaaaaagaa attatttagg tggttagtga gggtcagaga gtcctcggta 70561 agatttgcct tttaacaaaa agcagcccca aaatcatttg tttgctaaca aagagaagcc 70621 tgtaaaattg agctgcagac atagataagc aagctggaag cttgcacggg tgaatgccgg 70681 cagctgtgcc aataggaaaa ggctatctgg gggccaggca tgttcaacat ggattctcca 70741 tcttcccttt tctttgtcaa ccaagtgtac agtaaaggaa caggcaacat ggcacgggcc 70801 aggtagagaa cccttctgca taataaaaga ttagggtgag atggccagct tcttcccgtg 70861 ctatgtaaat ggcatacctg gtccaaccag tcttttgggc cctgtgtaaa tcagacaccg 70921 cctcctcaag ttagtctata aaaccccatg cattttaccg tgaaactggg agatccactc 70981 ggaaccccct cctgcacgag agaccttttc tcttttgcct attacacttc cgctcttaaa 71041 ctcactgctc atgtgttagc atccttgatt tccttggcat gaggcaatga accttgtgta 71101 ttaccccata caaatgatgc tgcttcatta ctaatagcaa cctgacaggg ttgtgttggg 71161 gtataaatta tctagaccag ggagatccaa tataattttt ttgtaatgac gggaatgctt 71221 tgtatctgca tcatccaaaa tggtagccac caggccaggg tgaaatgtgg ccagtgtgac 71281 tgaggaactg aatgttttcc atgatttaat ttaaatgtgg ccaatggcta ctgtaggaga 71341 cagtgtgagt ctggcatatt ataaataata aatattaata taatttgaac tttggcatca 71401 gtgtttccta gatttgaatt actatgcaag ttgcttactg tttccaagcc tcagctttct 71461 aatctgtaat tggggctaat aatagtatct gccttacagg tttgttcaga ggataaatga 71521 gaaattgcat gttgagggct taacacagtg cctggcacat aaaagctctg gtaacagtta 71581 gccactttaa taatttgcta ataatggcta tttcttcttc agattaggat gtgctccccc 71641 aaacagtgca cttagacata gcgggcaatc cagctcactc tctgcagtga gagagaagca 71701 ctggccgacc agagtcagcc aggggctcat gggtatgaaa tcaacagcat gattttgtaa 71761 gtaatggatg gaaagggcct cacaacttta tggcactgtg ttcaatttgc ttggtcttct 71821 gtagctcctt ttgaaagcct tttagggtgg attaacctgc taccaataat tctggtcaga 71881 tgtagactcc atagctcaaa gcaaactgag agagtgaggg cagcaggcca attccccacc 71941 ccttccttct ggactctgac agaagcttac actcaaggaa gagcaagtag gaattaacgt 72001 gttaagagct aggtaagcaa aacccaatga gaagttctgg caaagcccca tgggcagggg 72061 tggcttaggc acaggaaaca agtaggattt cataccacgc gcctcagtct acttccgggg 72121 ccctcatcct cagctgtgcc tatgcaaagg agagcaacca ataaacccca ccgccactct 72181 cctactgtgg aggccaggga tggccagggg taagagaggg atgggaagtg tttcctccag 72241 ccgtcctctg agaaggagag gaaactgggc agagcttctg tcctccttca agcagaaaca 72301 gaaacaaaag aaacccctaa gggggttctt acttcccctc tagttcagtt gtgcactaac 72361 catctgcagc tcaacattca gcattcattc attgattcag caaacattga aggagggcca 72421 gctatgtgcc agatgccaac tcatgccatg aaagagagtc cctgtcctta tgaaattcac 72481 tatttagaga gaaaagcaag caaaaaggca aagtttgaaa agtactgttg aagtggcatc 72541 attgtctggg gtgaatacct gaggtttgtg gtctcacgcc aagggaatca aggactcagg 72601 cacacaagaa gtgagtttaa gagcagaggt ttaataggca aaagaaagag aaaaaagaat 72661 agctctcttg cctgcacaga gagaggggca cctgagtgga tcttcctgtt ttgtggtgaa 72721 atgcaaggca ttttatagac gagcttgagg aagtggtgtc tgatttactt aggacccgag 72781 agattggtca gaccaggtgt gatgtttaca tagcatacaa agaagctggc catcccatcc 72841 taatctttta ttacgcagac ggggtctata cctggctggt gccatgttgt ctgttcctta 72901 ctgtacacgt ggttgacaaa gaaaagggaa gatgaagaat ccatgttgaa catgcctggc 72961 ccccagatag tcttttccta ttggcacagc tgccggcatt cactcttgca agcttccaga 73021 ttgcttatct atgtctgcag cccaatttta caggttgctc tttgctagaa aagaaatgat 73081 ttgggggctg cttttcatta aaaggaaaac cttaccaagg ttaaaaagaa aaaaatttct 73141 ttttaatgcc tatgttactg tgaacagtgt cgggataagg ctctgagagc cagatgagga 73201 tgagttatcc aatccaagga tgggggtctg gaggaaaaaa tcctagagag cattgctgca 73261 gttgaataag gattagttag aagctactga gtggagcata ggagtaggaa ctcttatgca 73321 aatgtgcaga ggtgaaataa agcaaggtat agtccaggtg cctaaagtag cacagctgac 73381 ttgagataga rgatagatag gtagatagat ggatagggta catagatgat agatagatag 73441 atagatagat agatagatag atagatagat agacagacag acagacactg gtgtgagtgt 73501 gggtgtgtgt gtctggctgc gtgcatgcat tcctcctgca ggagaccagg agcagtgggc 73561 agtatggagt gacaagaaga ttgggaggta ctccttctag ccctcccctc tgctctgccc 73621 tccactggag cagaagcaaa gcatatggtg aaggggaaca aggagtctcc ccagcacagt 73681 acccgagtgc attagctatt tatcactcca cagtccccat tcacgtgtta attcagcatt 73741 tattgaatgc ttactgtttg caatgtctat gtcaagctgt caagtgtagt ttttattcta 73801 caggccacag gcacccccta actgtgttaa acaagatggt agtattgaga caggaataat 73861 aagggtggtc acaggagaat ggaagattcc aggcagcagt ttgactagta aaaaaggaaa 73921 ctgttgaaat agctgcataa tccaggggtc aataagaacc tgagaaccag ggtgtgagcc 73981 aaggctggtt aaaagcaact ggatccaata tggtgctgag tttctcctag gttttgcctg 74041 gaacctcatt atatgctcaa taacatacca aatcacacac ccaccagggc cattccattt 74101 cctggaacac tcatgtttgg tgtaaaaatg ggtggcacca cagctctgag aaatctttac 74161 ctttttcagg aaacttcatg aatattccat cctttggtta aagaaaccca taatgtagaa 74221 gccccaaacc ctactgggcg caactctctc tctcttgagt atgcctgcac ttccctttat 74281 tatttattta tttatttatt atttattat ttatttttta gatggagtct ggctctgtca WO 00/09525 PCT/US99/17712 EPI-109 1123 74341 cccaggctgg agtgcagtgg cgcagtctca gctcactgca agctctzzct ccagggttca 74401 ggccattctc ctgcctcagc ctcctgagca gcagggacta caggcgccca ccacaacgcc 74461 tagctaattt tttgtatttt cagtagagat ggggtttcac catattztat tttatttttg 74521 agacagggtc tcactttgtt ggctcgctgc aacctctgcc tcccaagctc aagcaatcct 74581 ccaacctcag ccccccaagt agctgggagg acagacgtgc accaccacac ctggctaata 74641 ttttgtattt ttttttgtag agacagggtc ttgccatgtt ccccaggctg gtcttgaact 74701 cctggactca ggtgatcagc ctgcctccac cttccaaagt gctaggatta caggaatgag 74761 ccaccccacc cgaccacact cccatttctt gagtgtgtgc attttgctct gcaataaac 74821 tctctacttt cacttttctc tgactcgtcc ttgaattcct tcttgtaaca gcgtcaacag 74881 cctggacacc aggtgcagtc aacgtctcac cagtgtttag ggacctcccc taatccactg 74941 gtatcagcat gatcagactt gctttttcag aaaaagcctt ctgtccatag accaaaggga 75001 agtgactcag agaaggggca ggaggaatca caagctccct gcctgaccag gcctggacra 75061 tggcagagac agtgagatgg tgagaaagca agggtagaca gccagccaaa tccagaatat 75121 agaaagttct acaggaaaag gtggggccaa ggtgggacag ggggaaagga attgttgcac 75181 attaacagtg caatgcagag cactggtctt gtttatgtcc aggttagaac aaaccaatga 75241 gaaagcacat ctttgagaca actggagaaa tttgaacact gactagatat aatattatgt 75301 taattatgct ttaatttggg gtacaataat gcttttgtag ctatttctaa agagtcctta 75361 tctcttaagg atacactcta aaatactagt ggattaagtt atatgatgtt tagactcttt 75421 ttaaaataat ccagtggggt gagaggcaga gggaagggag aggagcatag aggaaacagt 75481 gttggccata tgtttgtaat tgttaaaact gagtgatggg aatatagaga tttaacatat 75541 taatactatt ttctgcccat gtaatatttg aatattttca taataaaatt gagagagaga 75601 taaagaaaga aaagagaaaa gaagagaaga gagaagagat aagggaagtg gaggaaaaag 75661 agctttcttc aaggaccatt gtggtggaca caaatgaaag ataccccctt cctactatga 75721 attctaggtg tgtactaccc aagatgagtc aatcggatcc tagcttccag aaatcgtgag 75781 catgatgcag ccctacagac gcagtgccct ggaaaggaga cccatgacca tccaaggaag 75841 atgtcccatc acagaactgc cctgggtcat gtgttttcca agtccacatg tccggtagtt 75901 ccttctttcc tatgaccaat gccaccagtc ttccagcact gtccttatt gctaggcaaa 75961 cctgagccat cctcttcttc ttgcaacttg tgcctgaagt aacacgaca caaagtcccc 76021 acttttccca cattctcaga atgaagtagt tctccctcca cactttaggt gctagaggca 76081 agtggattgc ttgagctcaa gagttcaaga ccagcctgag caacatggca aaaccccgtc 76141 tctacaaaaa atacaaaaat taactggggg tggtggtgtg cacctgcagt cccagctact 76201 caggaggcag agaaggagga tttcttgagc cctgaaggtg gttgtgttac gtgcattcat 76261 gttaagagac caccaaacag gctttgtgtg agcaattaag ctttttaatc atgtgggtgc 76321 aggcagactg agtctgaaaa aagagtcagc aaagggagat agggatgggg cggttttata 76381 ggatttgtgt aggtagtgga aaattacagt taaagggggt tgtcctcttg cgggtacagg 76441 cgggggtcac aaggtgctca gtggggagct cctgagattt attgtccagg agaaggaatg 76501 tcacaaggtc aactgatcag ttagggtggg gcaggaacaa attacaatgg tggaatgtca 76561 tcagttaagg caggaactgg gtattttcac ttctttgtgg ttcttcagtt gcttcaggcc 76621 atctggatgt ataagcgcag gtcacagggg atatgatggc ttagctcggg ctcagaggcc 76681 tgacattcct gtcttcttat attaataaga aaaacaaaac aaaatagtga tgaaatgttg 76741 gggcagcgaa aatttttggg ggtggtatgg agagataatg ggtgatgttt ctcagggctg 76801 cttcaagcag gattaggggt gacacaggaa cctagagagt gagagagatt aaactgaaga 76861 aagattttgt ggtaaggggt gatattgtgg ggttgttaga aagagcaatt ctcatataga 76921 atgattggta atggcctgga tgcagttttg tatgaattga gaaactaaac ggaagacaca 76981 aggtctgaat aagagaagga gaaaaacagg cattaaagga ctaagaactg ggaggaccca 77041 ggacatccaa ttagagagtg cccaaggggg ttcagcataa ttatttactt ggttggtgag 77101 tttttggtct ccatccttga gtttttttta tgttgtcata tgccaggcca gattgattta 77161 ggtaaaaaca acactcttca tttaaaaata tacagagttc tcctttctca gcagtgagta 77221 agtcaaggcc tcagcagttt tggaggaaag agaaatgcaa aggaagcaat tgtttgttaa 77281 gaaggattag aaatggctag gagagagtga gtgagattga tagtgtggtg gagatagctg 77341 aggagaggta gagggtggca taagaatggg aacgagaata agagtgagta taaaagtaaa 77401 gaatagaact tcatcagggt gaaagtattg gagggtgccc tgtcagcaaa gatcatctgt 77461 ccactccaag agggagtcaa gagtggcgga ttggggatag taccaggaga tatccactat 77521 gatggtttgg aggaaaagtg taaactggca gtgtaaacag gggcagggca tttatgagtc 77581 attgagaatg gtgaatagga gtatgactag acagaagata gtggagatga caaattttgg 77641 gggcacagtc caaatagtgg gggtgactgc gtagagctct gttgcaaaaa gtagggtaag 77701 gataaataga cttaatagaa tgaagagatg tattaggctc ataagggtta ttattgttct 77761 tcagaaatgc gagtgagttt aagggaagta ggggtgagta cttgcgactt ccagaaggaa 77821 gaggagagat caggctggct gtctgatggg cacagcttta ttctggaaca gtgaatccaa 77881 tggggagggt cgtgcagacg gatggcagtt ggggtgctat aaatgaccag gtagggtcca 77941 gtccatcaaa gctgtagagt gtgaggggtc agacttgaca aggactgatt gcccagctaa 78001 ggtatcttca catggctggg agtttggagg aggcaagaga agattagcag cctggcgaat 78061 ttcctgtcta gcctgctgga ggactggaag ataaaggcaa caggtcgtgg gcctggatcc 78121 tgtgtgagga ctctagcagc acagccttgt atttcagctg tgtgtaagga aaaaggatgg 78181 gacgagtcgg ggagtgctag tgtgggagct gtctccaggt cctttttgag agagtgaaag 78241 gaagaatggg gaaaagactt atggtctatg ggattagtta aattaccctt tgtgagctag 78301 taaagtggtt tgattaggat agcaaagccc ggtatccaaa gttggaaata tccaacaatg 78361 cctaagaagg aagggagttg ttgtttggtg gtgggggttg gggtctggga gattaactga 78421 acagagtctg caggaagggt atgtgtatgt tgatggagca ttataccaag ataggtaatg 78481 ctaggggaag aaatttgtgc ctcagagggc aatactttgt acccctttga gtaaagatgt 78541 tgaagaagca ggctagtgtc ctgctgggaa gattggtaag aggggctgca aagaagaaga 78601 tcatcaacat attgaataag gtgggaggta gatgggtgaa aagaaaacag atcatgagaa 78661 agggcctggc caaagtaatg tgggctgtcc ctgaagcctt ggggtagaaa aatccaggtg 78721 agttgttggg actggtgggt gtcagagtca gtccaagtaa ggcaaaaaga ggctgggagg 78781 agggatgcaa ggggatagta aagaaggcat ctttgaggtc gataacagaa tagagttgtg WO 00/09525 PCT/US99/17712 EPI-109 1124 78841 gaagggtgta ttgaagaraQ gagggtgtac gggtttggca ctataggatg gatgggaagg 78901 acgatttgat caacaagacg aagatcctga acaaacctgt aagacttgtc cggtttctgg 78961 acgggtagga taggggagtt gtaaggagaa tttgtaggct ttaagaggcc atgttgaaac 79021 aggcaggtga taacaggctt taaccctttt aaagcctgct gtgggatggg atattggcat 79081 tgagcggggt aagggtgatt acattttaat gggatgataa ggggtgcatg atcggttgcc 79141 aaggtaggag tagaggtttc ttatacttgt ggattaaggt ggggagatac aaggggagga 79201 tgtgaaacag gtcttgagtt gggtaaaagt gcagcaaaga gatgtggctg cagcccagga 79261 atactcaggg aagcagataa tttggttaaa atgtctcagc ctattaagga agctggacag 79321 gtggggataa ctaaaaaagt gcataaaaga atgttgtcca agttggcacc agagtggggg 79381 agttttaagc ggtttagaag cctcgccgac aatacccaca acagttatgg aggcaaggga 79441 aacaggccct tgaaaagaaa gtaatgtgga gtgggtagcc tccgtattga ttaagaaggg 79501 gacagactta ccctccactg taagagttac ccaaagcatc tgtgatggtc caggaggctt 79561 ctgaggtgat caggcagtgt cagtcttcag ctgctaagct gagaagatct gggaaggagt 79621 cagtcagaga gccttgggcc agagttccag gggctctggg agtggttgcc aggcaagttg 79681 aacagtctga tttccagtgg ggtctcgcac'agatgggaca ttccttggcc cagtggccag 79741 atttccggca cttgaaggaa gatcctgggg gaggaggtcc tggagaaatg cctggcccct 79801 gcagtttagg tgttttgaag ttcttgtgtg ctggagatgt ggctggggtt tctcttacag 79861 cggaggcaag taattgcaac tcagaaatat gttgtcactt ggctgcctct tttctattat 79921 tgtacacctt aaggcgaggg taattaaatc ctgttgtggg gtttgagggc tggaatctaa 79981 tttttggagc tttttctaat gtcaggagca gattgggtaa taaaatgcat attgagaata 80041 agacggcctt ctggcacctc tgggtctaga gaggtaaagt gtctaagggt tgttgccaaa 80101 caggccatgg actcagctgg gttttcatat ttgatgaaaa agagcctaaa cgctaactga 80161 tttgggagag gtcagctaaa gaaaaaggag cattaacctt gactatgcct ttagctctag 80221 ccacctctct aagaggaaat tgttgggccg gtgggggagg gctagttgtg gaacgaaact 80281 gtaagccaga ccaggtqtga ggagagaagg tgaccaaagg tttatagggt aggggagcag 80341 aggctgggga agaattggga cctggctagg cctagcgagg aacagcctgg ggaggagggg 80401 agaaatcaga tgggtccgta gaaaaggagg attcaaagga ctcagagctt ggggtggaga 80461 ctgaaggaac agacaggaga gaaagaggaa agatttggga tgagtcacat tgggagcaga 80521 gactagagag ggactgatgt gtaaagaatg cctggacgtc aggcacctca gaccatttgc 80581 ccattttacg acaaaaatta tctagatctt gtaggatgga taaatcgaaa gtgtcattct 80641 ctggccactt ggaactattg tcaagtttgt attggggcca agcagtatta cagaagaaaa 80701 taagatgttt aggtttttaa aagagtgcat aaaagaatgt tgtccaagtc catgcccttc 80761 ttaatcaata tgggagctac ccactccaca ttaccttctt ttcaagggcc tgtttccctt 80821 gcctccataa ctgttgtggg tattgatggc caggcttata agccccttaa aattacccca 80881 ctctggtgcc aacttggaga ggtcaggtgt tagtcaaagg tgttttaagt tttaagaaca 80941 caggctaagg gagaagaagg gggaatgaag cgtggaaggt tgcccatagt gaaagaggta 81001 agtttaaaga gaaaggtaga gacatggaga aggggggagg tgagcagccc tgggctgtca 81061 tgtgggttag cagccaaagc tggtgtccca gcaattgact taccaccaag ggaatgtggg 81121 tgaatgacca aggcaggcat ccccccggtg atcagacacc aaatggaatg tgggtgaaag 81181 atcaaggtag gtgtccccat gatgatcaga caccaaagga aggctgtctt cccaaatcca 81241 tgatccatgt tggagttttt gagttcatgg ataaaatgtg tctcctttgt ctctactaga 81301 gaggaaaaag aactggaatt tgaaggacag ggagattgaa gggtagggag agaggctgaa 81361 gaagagagtg aggagaccgc ttacccggtt tgaaattggt gagatgttcc ttgggctggt 81421 ctgaggacct gaggtcgtag gtggatcttc tcatggagtg agggtgagga gaggggacca 81481 atctcccgaa ggagtcaccc tgtccggggt cttcggcacc aaatgttatg cgcatccata 81541 tgaagagacc accaaacagg ctttgtgtga gcaataaagc tttttaatca tgtgggtgca 81601 ggcagactga gtctgaaaaa ggagtcagca atgggagtta gggttggggt ggttctatag 81661 gatttgggta ggtaatggaa aattacagtt aaagggggtt gtcctcttgc aggcaagggc 81721 aggggtcaca aggtgctcgg tggggagttc ctgagactca ctgtccagaa ggaatgtcac 81781 aaggtcaatt gatcagttgg ggtggggcag gaacaaatta caatggtgga atgtcatcag 81841 ttaaggcagg agcggcctat tttcacttct tttgtggttc ttcagttgct tcaggcaatc 81901 tggatgtata tgtgcaggtc acagaggata tgatggctta gcttggactc agaggcctga 81961 caggttgctg cagtgagcca agatcacact actgcactcc tgcctgggca acagagccac 82021 aaaaaaaaaa aaaaagaaaa gaaaagaaaa aaaaagaaga agaaaaaaaa attttttttc 82081 caccaagaat ttagtaaaaa attataggga aaagtgtcac taattcaagg gaattgcact 82141 gaaaattatt cattcattca acagatattt attgagaagc aagtatgctg gtgctagggt 82201 tacaacagcg cacaaattct tgtattcaag gaatgaggta agagtatgca gataggagcc 82261 agagaggtca agaggcaatt gcaacataga gtgacacgtg ctccagaaca cataggaggg 82321 cttccaggcc ccatgctggg ctatcagagc tggcttcctg caggtggtgt ggctcagcta 82381 aaacctgaga accaagaatg agccttctga tatctcaggg ttaaatcggc acaaatgaaa 82441 ccattttata accaaacaac attttccctc ctgaactgca ctttttctag aacccattta 82501 atccttccta acatgttcaa tccagccccg tgatttttca gtcaaatgca agatgcgtag 82561 gattcctttt ctgttcagtg ctccccagcc aatctttttc ccttctccca ccccacagtt 82621 actaattcca gcgtttcagt tctcagcaga ggatgacagt tccaccagga gacatcagtg 82681 ttatctggag acattttagt tgtcccagct gagggcacag tgctgctggc atctagtggg 82741 tgaaggtcag gaatgcacct caacatcctg gaacactcag gacaatcccc agcaacaaaa 82801 acctacccat ccagaacatc aacagggctg tggctgagga gccctgctct agtgcttcct 82861 ccttactgta tcctcatcaa ggagggctct ggggcatgtc aggggctgct acaggctcct 82921 ggcagatttc ggcgacttac tccagacttg tggaacattc aggattctta gcatggccac 82981 aggagagtca ggctgtccac aagcactctc tctttcttca cccactcatt cctgtcactc 83041 taccatttcc actgccttcc caaatgccca tcgtgagtcc caccaggggc cagaacacca 83101 ctctctcaag cctccccagt ggcgcgtgca cacctggaga acatatctca catcccccag 83161 ccagcgagac gtcctgagat tccagcactt ctcagtgtct ttcccagctt gtttgtatct 83221 ggaatggggt ggggtctctc acacaggaga aattacaagg aaaagtgtac gtgacaggaa 83281 aggaggaatt tctgtggaaa cggtgtgtga gaaaaegtag gaagaaagaa acttcaggaa WO 00/09525 PCT/US99/17712 EPI-109 1125 83341 atggtaagta acatcttag agcagaaagt gagaagggag cagaaagaaa tggggctgga 83401 acctgggaag gagaggacag gtggggatgg ccttgcacac cgtgggcact gaggagtgtg 83461 ggcccatggc atgggtggag aggagtttca agatagggag tagattccta ttttgaactt 83521 cggattgccc ctggcgatgt ggagactgta ttggaagaag gcaagaatgg aggagagccc 83581 ctaggtggag gtttggcaat gctctctcca gaatatagca gaggcctctt ccaaggtagg 83641 aaagccctga ctggagagaa gttaatggct ctgagggctc aagggaggac ttggattatc 83701 aggactttta aggaggcata tgatcaaggc tgggtcttg gcccattgaa atggggagca 83761 ctggttttag gatgtaggtc aattagtttg gttttcagga caggctgagt tggatatcct 83821 gggggacctc caggtggcag tgtcagggga agctggatgt gctgacactg aactcagcag 83881 agtgactgag raaagatcga catctggggt cacaggcagt ggatgccgta ggggtggact 83941 caatagctca agcagaaccc ggaggaatgc aggcagcaaa gggagcccta aagaacagtg 84001 aggagatgtg ccaagaaaga gccaaatccg ggggattggc tgtgggagag agggctgtgg 84061 gagtaagagg aagtgtcagc aacgtcaaat gttgcagaga catagagtaa ggtaagagtg 84121 gaaaaaacat ccatggaacc ctgtgatgca atcggaatgc agaaagactt tgtaactcct 84181 gcctggtctc cccctgcc cactcatggc aaaggaatac aaagtaatgt tccctccttc 84241 cgcctagaaa agcacaactt ctgcccccaa gccctgggct ctcctgagag gacaggacca 84301 gcctctgaag ttgaaggtcc tggttctgcc cccaagccct gggctctcct gagaggacag 84361 gaccagcctc tgaagttgaa ggtcctggtt taccagatag ggaaggggcc ctttccaaga 84421 ccctttccag aaggtgtggc tgagatggga accgtggact ctgtgcagat gtaggagctg 84481 gctccagtca agrgctagga ggttgtgggt cctgggaagg aagaggctct ggagcctctg 84541 tggagactct gggactgtcc ttgggggaga cgtgagcagg aagaagcagg gccttcacag 84601 tccccagctt aggggcctca ccacccagac tgaagaccag gaccaaaccc tttcctgcac 84661 agttacaatg tgtcatttaa ttttactaaa gggaatattt tttaaatgag gatgctactt 84721 tgtgtattaa tttttacctc tattcataaa agaaacgttt cttatctatt taagatgatt 84781 catatcagac cagtgtctgc ccaactcgac tgaccctgtg aaaactgggc acttcacact 84841 ccaatgatga tggatgagtc cccagcagca tagtttaagg gagtgagtgg gcagtgtggc 84901 ctcctgtgca cgtgacttcc tccttcagtg tgcccacatg tgggttccac ggtcttgtga 84961 cattgtggct ttagaaattt ctgtttccat tttctatcat tcagagtaaa tgaaatttgc 85021 aggaaattca gaaccttcca cctgtacagt ggatactgtg agactctgcc cagatgccct 85081 cttcaagcca atgcatctct ccatgctccc actcccatag atgggaacag aggtgctgga 85141 actcagatct actccccttt ctgggaactg gagctgcctg cccaggcaat gcccccttcc 85201 cagggatggc tgagccaatg actggctaat gttggattgc agaggcctag cgccctcccc 85261 tcaattccta attccttgta ggaataactg aggcctcctc tgtgaccacg tgggcagctt 85321 ctccctctgc ctggtcctgt cttgttctct cctttccaat tgtgtctcct ggaagccctc 85381 cccacaagtc tgctgcatac aactctcctt ctcagagagc ctgagccctg gattcccagg 85441 aatccagcct aaaatagtct ggcatttggt ttcaattttc tctttcacta agactcagtc 85501 acaggtgcta ataaataata aaatgtcacc accttgaatt ctatcactct ctcttttctt 85561 gccccatctc tgacaagtag gtggtccctc aagaacctga aaagcagaca ttaggaggaa 85621 aggaggagtg ggggcaagag gcccacacct cacctggccg gctcccatcc atgcgccctt 85681 gactgaggta acacctaccc tgggaatcct tcccctgcct ctcgtgagcc aggccgggtg 85741 ctcttgggac agctcccact gctcctgtgt gctcccccag cttggcacat gactccctga 85801 attatagica gttccgtacc tgaatctccc tctagaatgc cagtgccacg aggacagagg 85861 acggttccac tttgttcact attttctccc cagggtctgg caaagttcct gggacttggg 85921 agaggtgtcc ttcaggagct tggcagaagc caaacggcac acttaagtag ggcaactgag 85981 gtgagtttaa tgaaggattc tatacaaaaa tttggacaag gtatagggag gccacaatac 86041 acagtgcagt gcctggtgcc agtgagagca gggcactatt cccactgcaa ggccagacag 86101 ggcaagggga gggagctgcc tgacaagagc tgcccttacg tcaagggaca catcagccca 86161 ctagacccca tcaggaggga gccagggcct gactcccctg accttgctct ccaatcttct 86221 gcctaaaatt ccccatcagc caaacacaac tgaaaactga aagacagggg agcctgctgt 86281 taataaggtg agcttccccc agaataaagc tgggtagaga gtggagaatg gatatggaag 86341 ggcaaaagga agatttataa gacagtgggc actaaatatc tatgagatga ataaaggaac 86401 cacattttac aacaaacggt cattgaaacg ctactcaatg gaaagagatc atttcggtca 86461 ctgtctggtg cagacaaatc aaagcccaca tgcatcaaaa aggccatgtc cgtgtaactc 86521 cgacacgggg cagacagcaa ggctgaagcc tatggggtat gtggagccgg aactgagaga 86581 tcctgatgta aatctagcac ttgggaaaag ggggactaga agaaattcac ccacaggcag 86641 aggaaaacac aaacacttat ctatttttgc ctaggcttta agtggtatgg gaaaaatctc 86701 tgagactaca aatcctgtgc ttcatgcaca ggtttataat accctcaaaa tggaagaccc 86761 caaaaccagg cgcggaaaat tcatatcagg ccattgatgc cctcaatgtt cccggctgaa 86821 acaaactcaa aactcctctg gaaaggagtg ctcccacttc aagccatgaa aagctactgc 86881 agagaaaata atccccagtc aagacacact cacattgaaa ctgcaaggca cacaaggaaa 86941 tggatcacct tgagtgatag ctggcagagc taataaacct ctgtatacct ctaagaagct 87001 ccacgcacta gtataaccct taaagatttg atgaaatcat tactttatta aaattgtttt 87061 tataaaaaat caaaatccaa aaaaagcaac aaattttata ccagagccaa ttcggtatat 87121 acaagggtgt cttactcttt tggaatttgt cttattgtcc taactcagca cattgtcctg 87181 gtctatgaaa aatcctagaa acccttctac cctctgtaat gtaggagctt taactcaata 87241 gggtttttta aattcttttt tcttgtcttt ttttcttttt taattttttc cattttttca 87301 agtcaaactg aagaaatatt tttcttttct ttctaggaat gcatattcac cccccaaggc 87361 cacttgtctc ctgattggag agtattagac aattctcagg atttctttat tttccttctt 87421 tattccatag gattgggaaa cccagtagga ttgggtttag gcatatctct aaagcaccat 87481 gtttcaacgt tttgatgtaa gattgtgccc tatttcttgt tcagttgctg ccagcagatg 87541 ttatagttc aaaactagtt tttggtcatt gagatattag aggagggaag agtctgctat 87601 cctgctttac tcatcttcat ctacactaca ctgtcatctt cactgcaaag tcctgtatta 87661 atgtttttag accataac attttaacag gtgtcaaaaa atcttaagca ccacttcagc 87721 tcgggatccc ccaaatgtaa tggtgtttgt gggctggact gatgtctgcg tcttgttgtt 87781 gttattgtct gtagtaatgg agagccggga gatcctggac acttcctgtt catgggcact WO 00/09525 PCT/US99/17712 EPI-109 1126 87841 tgatgcatta gctgccccag cagctgatta catttaaaca aggatgtgtg ggtgaaccca 87901 gggagaccaa tctcagtgga atggtggggg cagaagccag gctgcagggt gtagagtagg 87961 gaatgagcag tgatgaagta gaaacagagt ttggacaact agtgaaactg cctggaagag 88021 ggggagaaga gacagtaaat ggtctgacca atgtttgagg tcaaagtggg tttgtaatct 88081 ttatttaagg gacagatcrg agcatttaaa aattctgaat aatctaatag agaggaaaaa 88141 gttgggactc aaagaaaatg tgggaaaaaa tgatgaaggt taaacggaat gagatccaga 88201 gtgcaggggg agagattagc ctttggtgtt agaggagcaa ctctgtccat ggagagagga 88261 aaaatgtaga cataccacag ttgcatttga agttggggcc tgaggagttg aggagttctg 88321 agaaaagcag aagatgagat catttcctga gagtaaatgg gagtcattag aacgggggtg 88381 aagagactgg aagctttagg tagcttgaaa tagttgatgg aaaaattgga taaagtgaca 88441 atttgtcaca ctcagaacag ctatcaggga atctagaaga atctctggaa gctagttgaa 88501 gatcttaaat taccaatgta tcttgtccac atagctaagc ggttttactt atttttattt 88561 ttttgaaaca gggtctcact ctgtcacaca ggctggagtg tagtagtagt agcacaatca 88621 cagctcaatg caatctctgc ctcccgggct caagcaatcc tcccacccca gcctcccggg 88681 cctgggacta cagacacaca ccaccactcc cagctatatt ttgtacattt gtagagacag 88741 ggtctcgcca tgttgcccaa gctggtcttg aactcctggg ctcaagtaat ctgcccacct 88801 cggcctccca aagtgctggg attacaagct tgagcccggc tgctaagtgg ttttaaacag 88861 ctgttctcgg aaacacacac tcaaagaaaa aatgtagagg ataatttatc taaggctggg 88921 gcttcaagag aggtcagggt gttgacaaga gaatgactaa gtggcagact actggatctc 88981 agctagataa agagggatgt gatcgtggga ggggctgata gtcagaggct ggaaggcttg 89041 atgaacaaca catattacac aaagaataaa tggagtgaga gaaaccaaag gagtaaaagt 89101 tgtcatcaga aaagtgagaa attttattgt gagaattcag tggtaaatca atgttaacaa 89161 acctcagctg ggcactagtg gagtgaaacc gaaggccagg gagttgagtt aatgagctga 89221 gacttgggca ccagatgggg gtccacatgg acaactaagc caccaggatg atgtgggaaa 89281 ctggggtgaa tagaagcccc ttatccatgt gcacaagtct tgaataaaat aggggcaacc 89341 aggcagtcag tggatgatag cagtgaggtg gagcagagag caatgtagtt ggagaagtgg 89401 agcccacagc agtctccttt atatctagaa gggaattaat agccaaaaaa tggcaccgag 89461 gccaaggatg tcaccttctg actcccaaat ctgagacaga tgtgagaggg aaggagtatc 89521 ctcaagggac aggagatggt gcgaatgttt ttggcataaa tcaaagatgt cagggaaatt 89581 gtcagaattc aggttccaga gacacagagg aaaagcgtgg gagaaagtgg aatattggga 89641 ggtgagatta gggcagagga agcacaaatc aaagaacgag gaatagaaaa agtcatatga 89701 gctgaggagt tggccaaaca tgacagaatg ggaatatgat ggaattaagt ggctttatgt 89761 gttccaaaag gattggtcca cgcaggccac aggaaaatgg gaggtaagaa gaaagggatc 89821 gaaatgctgc aaagtgtatt acttcatggt aagcaaagga ctcaagactc tagaaaatga 89881 tgcccttcct tccaagacta tgttagtcca aatctttcaa gatacagaac ccaaggtggg 89941 gtctggcata caagaagtat aatagaggaa atgtctgtga catttgcagg actgcaaagg 90001 gagccaggag aagctgggaa agccatgaga tcacaagcag gtctgactcc aagtgaagga 90061 gatggggaat gacgcaaggt ttggctgaag catgtgccaa aggcacccat cagaggagtc 90121 cctctccaag ggatgggcct atcatagtgt ccctaatagt gtcatggagt gggagcagcc 90181 cacggagggc acagccttgg catgaacgca gacatgggtc tcagagtgca gcagctgggc 90241 ccctcagtca attaggctcc ctcagagctg gggcaggagg tgcactagac cacacagtaa 90301 tatttattta ttattaattt aattaataat attaatttat taatttaatt aataatatat 90361 ttatttattt attattacta gaccacacag tagtatttgt atgtctaagg aagcatttct 90421 cagaatatac tcactgaact tttagcctat aagtacctgt atgaaaattt taaaaggggt 90481 ttcatgatca aaacattttg ggaaacactc catacccttt cttcctcatg aaggatcata 90541 atgcctatta gtatatgaag ggctctgaga agtcctgtag taaagaaact tgctttagtt 90601 ttttagtcca gcaatttttc aaacttaaat gagcaatagc ctcccatcct tttttttaca 90661 ctttttagca tactgcggaa taaactcaac atgcattgag aaagactgct ttagggaata 90721 gtcaacacta tttcactccc agtaagtaca tataaaatct gtatttccag ggtggattat 90781 caacacagct gtattttaga aatattatct gccctcccag gtatcacagc tactaattat 90841 tgggtactga ggtggaattt tagggatcag ccaattatgg gaaagaaaat ctgggggcag 90901 gataagatgg tctccgaagc cttaaaatta tatgccatta tttacctctt tgatctacta 90961 ctcaatatca aacaactaat tcagaagaaa attgattgtt ttctaaaagt agtttttcta 91021 catttcccat taagaagcag tggtatttaa aacttataat ggctattatg tgagattatc 91081 actatcatag tttttctcta tacaaatttt ctgtaacatt ttatttgcta ataaaaatta 91141 gatagatgga ttgactaatt gataatctaa gaaagattat atttgaagaa gccatagtaa 91201 gggacagatt aaattatcat cagtctaaac attctaatac ctatttctct ttttttgaaa 91261 ttttccaaat ttgttattat gcatttaaac aataattttt tgaactttta ttttaggttc 91321 tggggtacat gtgaaagctt gttacatagg taaccttttg tcatgagggt ttgttgtaca 91381 aattatttca tcactcagct atcaagccca gtactcaata ggtatctttt ctgctcctct 91441 ccctcctccc accctccagt ctcaagtaga cctcggtgtc tgttgttccc ttctttgagt 91501 tcatgtgttc tcatcattta gctcccactt ataagtgaga atacaaggta tttggttttc 91561 tgttcctgtg ttagtttgct aagggtaata gcctccagct ccattcgtgt ttccacaaaa 91621 aaacatgatc tcgttctttt catggctgca tagtattcca tggtgtatat gtaccacact 91681 ttctttatct aatctgtcat tgatgggcat ttaggtttat tccatgtctt tgctactgtg 91741 aatagtgctg caatgaacat tcacatgcgt gtgtcttcat ggtagaatga tttatattcc 91801 tctgggtgta tacccagtaa tgggatttct gtttttagct ctttgatcta atacctattt 91861 ctcaagatca agttagatct ctaaaaaagg catcatccta gcatttcccc atcccttccc 91921 tgaactaaat ttaatgttgt gtgtatcaat cagcatacag tcaagacaga aaccacacat 91981 gaacattaaa tataatgagt tattaactta taaaagggta tgaactacta aagggggtaa 92041 ggagaatgct gaagaatgca ggaatggcag atgtagagag cagccataac ctctaagcta 92101 aggcacagca gccaaggaag gggcgaactc aaaaaatgcc ctccctcccc agctgatcca 92161 cccttgttag agggggtgtg gctgcaaccc aatggatgcc caagaagttt gcagagttgt 92221 ggcaggttgg ggctgctgag caggaaactg cccgaagggg taccagtgag attcccaaga 92281 atgtgggcat gcctctggcg aggaagacgc tcttggagtg ccagcaaaat tactaggaa WO 00/09525 PCTIUS99/17712 EPI-109 1127 92341 gctacccagt agggtgccag caaaagtcag caggaagcca ctgz:=zagt gtcggcaaaa 92401 ttcactgagg agtgggcact gcagggtctc cacccagcac tggcaaatca gccaaaagaa 92461 caaaaacaaa ataaaaacaa atcccagaac cagaaagaaa aaactzzgcc tcttactgcg 92521 accctcttat gccttctaca gcaactggca aaggagaaat gtttat-ggg tccagctcta 92581 gactcacaaa gcagaacaca gaagagtgaa tgaagagctg aaaggcaata aatcagtaac 92641 tggagcctca catcctttgc cttttttatt gagggtcaat atattaaaaa gaatatgtct 92701 gcgtcttcgg taaaattatt gctaaggtta tcacccagtg tgtgtz~zca acctccctga 92761 tataagaact tagtgacaag aaagaatgag acaatgatca tgaacta-tg gacccaacca 92821 tttgtggctt tagtgcccat cttctcagca aggctttctc tctctczctc tctctctctc 92881 tctctctctc tttttttttt tttttttttt ttttaagatg gagzctoact ctgtcaccca 92941 ggccggagtg cagtggcaca atcttggctc acggcaacct ccacczzctg ggttcgagtg 93001 attctcctgc ttcagcctcc cgagtagctg ggattacggg cacccaccgc cacccctcct 93061 ggctaatttt tgtattttta gtagagatga agttttgcca tgtcauccag gctgttctca 93121 aactcctgac ctcaagtgat ccacccacct cagcctccca aagtgctggg attacaggca 93181 tgagccacca cagccagctc tcagcaaggc tttttctgac tacaccattt aaaatgtgat 93241 ccctgagcca ccttggcctc tcttgctgtc cttccctgct tcgccttctc catagcactt 93301 ctctcctact aatctacaat ttacttgagc tctgtgaagg tcaggatttt tgcctatttt 93361 gtccattggt gcatccccag cacctggaac agagctaggc acaggctagg cactctagaa 93421 atacttgctg aataattgaa ttaagtaaat gagtgatcta cacgtaatgg ggaatgagag 93481 tatacagtga tagttccttc gactaaaact ggggtcaaat tatagtgata aagaggaact 93541 cagaccttca gaggtaagct ttgtggacca cttgccaagg ctgcagaatg tgatgtcgtt 93601 tcacaaacaa ggaggcccta ttatggcttc agatatgaga ataataaaga gaactttcct 93661 ttcgcctcaa ctgcagcctt ctaaactctt ccttccttcc tatgtagaag tttcaaggac 93721 ctcatggcct gagtgtggat aggcagaatg ctgggaatca ggcaaaaata aaataatact 93781 gaaagtgaag gtcatgctaa tattagtaag ccagggtgat cctgaattta caaaacattt 93841 ttctttggga aatttcacac ctcacatgat tctgtgtttt tacttgagaa atttcacatc 93901 tcacatgact ctgtgacatg cggtacatga ggtgcctgac tgctgttttt gtcctctact 93961 aatgaggaag agtgtgcgta ctcccagcgt tttgcaagtt tcaaaazctg acttgacttt 94021 ccttcctttt cctggaactg atccatgagt atcgagagta aagctgcccg cacctactca 94081 ttcaagatcc tgagtgtcct gcccagctgc aggaggtgga gagacccagg aggaggggcc 94141 actgctgatc ccaggctgta gggggtggga agagtgtccc agggcaccat gacccccact 94201 cactcactca caggagaccc acacaagaga ggagagggca cttacaactt aggttcccac 94261 cagcaccaac tcctctgcca tcaaacatca ttgtgtttct ctttctgcct tgtctgtcgg 94321 cacacgtgga gttaaattta atgctcaatc acatatttgt ctgggccctt tctgtgttta 94381 tttttctctt aatagttctc tctcctccct tcctctcccc gccccccc ctccttcttc 94441 tttttttttt ccagagacag tgtctcgctc tgccacccag gccagagtgc agagtggcat 94501 gatcatggct caccgcagcc tccaactcct gggctcacgt gaacatccca ccttggcctc 94561 tggaatgtct gggattacag gcacttgcca ctgcatctgg ctaattttta tattgtttat 94621 agatccggga tctcactatg ttgcccaggc tggcctcaaa ctcctgggct caagcgaccc 94681 tcccacctca tacttctgag tagctggggc tgtaggaatg cgcctcagtg ccaggctagt 94741 ttcttaattt tctatttcta ttttgacagg tacaaatttt gtattcaatc ctacctcaga 94801 cacatctttg gtgggaaaag gatgtcattt aatcaatata taaattctaa gcaaataggt 94861 ctgatcccca aattaggtta gtcacagctg ctgagtcgtt gacccaagag aagctcatct 94921 agattttttc attattttca agttcctctt ctcggttcgt ccttcttcca gaccatgccc 94981 tccccgtccc actctcttcc cacagcctcc cctccccaca gcctcczccc accattccaa 95041 atctgggctg ttctctcaat ttccttctct ctggactcaa acctacccta gcccccagcc 95101 tcagtttggg gttaaacttg tcctcctcac attctctccc acccaacttg atgtcgcctc 95161 tgtgtcatca ccacgggatt ttcctcctct gggttctcct tttccaagtg gggtcagctc 95221 ccccatgagt cacagcacca atcacttctg gctgcttgca aacccctttg ctttcctcag 95281 tgttgacacc cagggcagcc ctatgctcac tgccgctgaq accccacctc tgcccctggc 95341 cttttcccag ctgacatcac cctgtggcct ccattttcct aaaattctct tttgaggcct 95401 cagtcttaac caaagcacac agtgcccctc aaaaatgaca ataaaaaccc aaacacaccg 95461 tgactgtcat ggcaggttcc tggtccccgt attgaatcag cgggtgggtt tctgcgaaca 95521 ctggtgagag gccgcattag agggtcagga ccctcaggtc tggactcgtg gtcaccacat 95581 accttcctcc ctgctgacag tagctggtac ctgttaccta ctcagagtgt cacatgccac 95641 aagccagagc gtcttggcag ttctcagcac cttgacatca cttccttgct accactcaga 95701 gcggcagtga cacagttccc ttatctcaga aggccagaaq acggctgtca aaggtcacag 95761 ggaaatcaaa ggcggggtac agggccagag ggaggaggaa acaacttccc ggttgctttc 95821 agacgcttca gagatcctct ggaggcctgg gggagctttt gagtacttta tttcagttgg 95881 tccctgagct cggtgagtgg ggcgggtaga gccaccaggg gaatcaacag tggtttctcg 95941 tgcccctcag ggtcaggagc agtctgatca aaaggagggc atccactgtc cggggccatt 96001 cccacagctc ccggatgctg ggtctggagg ctgcgccctt ccccracagg agctcagccc 96061 agtggtaagt catctgtgtg tcatctatgt atttaacccc ttatggccat gttgatgctg 96121 agcatggttt cacttttgca aacatttatt tatacccttc gagagaaaaa cgtctcagct 96181 gtcacaggaa gctgcttcgg ggggtgagca aactttttaa aatgcagaaa ttatgatcta 96241 cacccgtttc ttaaaagtaa gccatcgtac ttggttctct ttaattatat attttcttac 96301 atattgtgtt catgtaggca agtcctgttt ctgctaaaag aaggtaagtt ctaccaaggc 96361 ggtgtcatgc cagctttatt tcccgtggca cctggcacac tgctaaacac ttacatgctt 96421 aacaactaga ttgggaatgg tgctgctctg gggaagtggg cacacartaa agaaatgttt 96481 atttcagtct tctgaaatag ggaattactc tggctaaaat gtagctccag aaagggaaag 96541 tggggctgta tgaatccagg tccagtttgt tgtttcctcc aggataaggc agctgtcgga 96601 ggggaaaatc atctcccatt tctccacagg gcagtctgaa gatggccaat tacacgctgg 96661 caccagagga tgaatatgat gtcctcatag aaggtgaact ggagagcgat gaggcagagc 96721 aatgtgacaa gtatgacgcc caggcactct cagcccagct ggtgccatca ctctgctctg 96781 ctgtgtttgt gatcggtgtc ctggacaatc tcctggttgt gcttaaactg gtaaaatata WO 00/09525 PCT/US99/17712 EPI-109 1128 96841 aaggactcaa acgcgtggaa aatatctatc ttctaaactt ggcagtttct aacttgtgtt 96901 tcttgcttac cctgcccttc tgggctcatu ctgggggcga tcccatgtgt aaaattctca 96961 ttggactgta cttcgtgggc ctgtacagtg agacattttt caattgcctt ctgactgtgc 97021 aaaggtacct agtgtttttg cacaagggca actttttctc agccaggagg agggtgccct 97081 gtggcatcat tacaagtgtc ctggcatggg taacagccat tctggccact ttgcctgaat 97141 acgtggttta taaacctcag atggaagacc agaaatacaa gtgtgcattt agcagaactc 97201 ccttcctgcc agctgatgag acattctgga agcattttct gactttaaaa atgaacattt 97261 cggttcttgt cctcccccta tttattttta catttctcta tgtgcaaatg agaaaaacac 97321 taaggttcag ggagcagagg tatagccttt tcaagcttgt ttttgccata atggtagtct 97381 tccttctgat gtgggcgccc tacaatattg catttttcct gtccactttc aaagaacact 97441 tctccctgag tgactgcaag agcagctaca atctggacaa aagtgttcac atcactaaac 97501 tcatcgccac cacccactgc tgcatcaacc ctctcctgta tgcgtttctt gatgggacat 97561 ttagcaaata cctctgccgc tgtttccatc tgcgtagtaa caccccactt caacccaggg 97621 ggcagtctgc acaaggcaca tcgagggaag aacctgacca ttccaccgaa gtgtaaacta 97681 gcatccacca aatgcaagaa gaataaacat ggattttcat ctttctgcat tatttcatgt 97741 aaattttcta cacatttgta tacaaaatcg gatacaggaa gaaaagggag aggtgagcta 97801 acatttgcta agcactgaat ttgtctcagg caccgtgcaa ggctctttac aaacgtgagc 97861 tccttcgcct cctaccactt gtccatagtg tggataggac tagtctcatt tctctgagaa 97921 gaaaactaag gcgcggaaat ttgtctaaga tcacataact aggaagtggc agaactgatt 97981 ctccagccct gqtagcattt gctcagagcc tacgcttggt ccagaacatc aaactccaaa 98041 ccctggggac aaacgacatg aaataaatgt attttaaaac atctatttaa tgtattttaa 98101 aataatttgt aagttgattt taaaaccaat ttaactacat tccaaattat agacagccca 98161 tttatatggg agtaactttt caggctcatt gcctcgccgg tgatgagaag aactagctag 98221 ctggaagctg tgggaaaaag aggtaaggta acttgttctg tcgaagttct ctaaattctc 98281 ttgcttactt gccacacccc taggccccca gcttccccta acccaaggtt tctggtattt 98341 tctcgtactt tatcaagact atggaatctt aggagactta acaaaagcaa atgagaaatt 98401 atgtttagaa atgtctaaca aaatgaattc tttgtccttt taagtataac acatacctca 98461 ggcctcacca gcacataact acaaaaggtt gtcccacttc ctttctgtgg ctgagttagt 98521 agaacacagg ctcccacctg ccacatcagc agaaggtcac ctcaacatgt gagctacctc 98581 cccggagacc ccccagatcc gtaaggatga tgcatccttg atcctaaaaa cattttcctg 98641 ttcctggtgt tcagaattgg actccacact cactggtctc tttataatct tgcttctggc 98701 cctttgaggc ctcaaagcta ccagggcctt gctgccaggg gacaatcacc gctcccggct 98761 gagtcctgca gacatagggc ctgggctggc tgcctcctcc tgctggccca gcatcttgct 98821 tgcactaaag agagctggag gcttggcact gatgcttgct aaaaacctac ccaggccgcc 98881 cactgctgcc gcactgcagg gcaccagccc acactcctcc cctcctggca tcaggcacac 98941 gttcacggca ctaaacctta caggaaagca gtggaaccct gtctttcctt cacaggaggc 99001 actttccttc ctaggcaaaa acgatgatac ccatgggcac agcatctcac atagggacac 99061 atagagatgt ctgactcatt aaaacccaag tctctggcca attaaaaggg gtccttaatg 99121 tcctactcaa cagtggtgga aggaaatttg ctctatattg atgaaatgag gtggagaaaa 99181 tctgattttc caaacatgag aattctccat atgccacccc ataaccaaag accccttatt 99241 tgtgttagat gaaacattca aagagcctat taggatagcg gatgagaccc ccaagggaca 99301 tgcttataca acaataactg gctccaaacc acactccatg gcagtggctc tcaaatgcca 99361 gctcacatca caagccctgt gctaaaacac agagttctgg gccccatccc ggagtttgtg 99421 gttcaggagg tctggagtgt gacctcagaa tatgcatttc taacaaattc cccaggggat 99481 gcagatactg ctgacccaag gccctccttc tgagaaccac tgttccaggg agaagaaact 99541 cagctaagta agggtttggc tttgtgctga agacaatgtg gaatttagag ttggggtgaa 99601 ttattcagga aagtagagag gtttggagat gtgagggtgg gaagcgcagt ggagggaggc 99661 agagaggaaa tatgaagcag cgtcagttgg agagaaatta ggaagaggaa taaaatgata 99721 tatgccaggg atttcagttt tgctgagccc atgatgacag actcttctct ggcaccttat 99781 gccactcatt gagggcttgt agctggctct gctctttcag agtcataata gggctatggg 99841 tctgacctca aggtgagctg gaatgggcac aagtaataga taaaactgca agaagtcact 99901 caagggtcct tcctagaaca aaggatccct acattccaaa ggcgaatgcc ggtcactatc 99961 ataaaagaaa agaaagaaag aaactgatgg tgacatttta aatggcaatt tttctagctt 100021 ctaaaaggtt gtggagcaac tggaactttc ataccctgct ggtgggaatg taaaatggta 100081 taatcacttt ggaaaaattg gcagtgtcac caaaagcaaa gcctatacct actatccatt 100141 tcactcctca gtatttaccc aagagaaatg agcatgtatg tccatacaaa gatttggacc 100201 caaatgttca tgacagcctt atttatatag cctcaaacta gaaaaagtct gtctatcaac 100261 aggtgaatgg ataaacaaat actggcctgt gtatctaatg gaatactgct catccacaaa 100321 aagaaacgag ctattgatac acacaggagc atgcacgaaa tctcaaaatg ctgaatgaag 100381 gaggccagat tttaatttta tttttaatta tttatttatt tatttatttt tgagacagag 100441 tctcgctctg tcacccagcc tggaatgcaa tggtgtgatc ttggctgact gcaacctctg 100501 cctcctgagt tcaagcaatt ctcatgcctc agcctcccaa gtagctgtga ctacagtcat 100561 gcacaagagc aactgactaa tttttgtaat tttagtagag acggggtttt gccatgttgg 100621 ccagctgctc tcacactcct gacctcaggt gatccacctg cctcggcctc ctaaagtgct 100681 gggattacag gcatgagtca ccgtgcccag ccggaagcca gatatttttt aaaagtactt 100741 attttgtgat tctatttata taaaattcta gaaaatgcaa acaaatccat agcgacagca 100801 aatcagtggt tgctggagat gttggagggg agaggagagg aatagattgc aaaggggaac 100861 aaggaaattc ggggggacag tggatatgtc tgctattttg actgtggtga tggtttcatt 100921 ggtatataca tatgtcaaaa acgtaacaag ttgtatacgt gatttattat gtgttgacta 100981 tacctcaaaa aggctatttt ttaaaatccc cctcaggctc caggcactcc attacgttgg 101041 tgtgacttgt cttggaaata tactttgagc atttgccgga ggagatccag tgcctgggcc 101101 tctgtttctt ctcccaagta gaattggcag ctaaaacggg atgcccatgg gcacaacttg 101161 tcacccccat caccgaacag ggagcagaag gaggctgctg ggggtgcccc cacagggagc 101221 acagtctcat caggaatgac ctgccatggc aaataaaatc accagggcaa gtcaagggag 101281 agaccaggga aagagtgat ccagtctata ttaaaaaagg atgagaaagg ttgaagaaaa WO 00/09525 PCTIUS99/17712 EPI-109 1129 101341 agagaagaag ggacagaaaz tctcttcaca catttgcaga agtaggtccg gactctccat 101401 ccacttctcc tcctccaata ggtaggacag gaacctcaga ggaaatggca tcatcttccc 101461 atgtttacag acacaqcaat gaactcaaag aacaatctta tcaggatttt ccaaatgaaa 101521 acatggagca tatagagaat aaagatccat aaactcgtat ggtggctgag actgaaatgg 101581 ttaatgaaaa gcaaaagtgt gtgctgaatg acaccagcca caatggcctg aacacttaag 101641 tagtgtaata tacttggaac attgacagct aacaaggtct tcctcccatg tcagaccaag 101701 aacacagttt cctaaagata aaaatagcac atgcttttcc acttttccat aagtgactgc 101761 attagaaaac taacaaacca tgaaaagcaa aatatggcta gtctcttcaa gaaaaactgg 101821 tgtttctatt ttgtctgtaa attactttct aatacaaaaa acaattcctg ttacattgag 101881 gtaattctaa ctagggacat atgagagaga gattgaaatc tcatgagctg tctccttttc 101941 atctcaattc tgtgtactcg tgggtacaaa tggaactagt ttttgtttgt ttgtttgttt 102001 tttgagatgg agtcttgcgc tgttgcccag gctggagtgc aaaggtgtga tctcggctca 102061 ctgcaacctc tgcctcctgg gttcaagcaa ttctcctgcc tcagcctcct gaatagctga 102121 gattacaggc gcctgccacc atgcctgact aatttttttt ttgtttgtat tttttagtag 102181 agacagggtt tcaccatgtt ggtcaggctg gtctcaaact cctgacctca ggtgatccac 102241 ccacctcggc ctcccaaagt gctgggatta caggcgtgag ccactgcacc tggcccggaa 102301 ctagttttaa aacaggaaac agttgatata ctgaatggaa aaacaataca atttgaagtt 102361 gaaaaaacaa aataagatgc ccagttaaat ttaaatttca gttaagcagc taatagttat 102421 ttagtataag tacaacccat atacgacaat tgcagtattt gttatttatc tgaaattcag 102481 acttacctgg gcatcctagt atcctgtttt ttgttttgtt ttgtttttcc ctttgttttc 102541 ttttttttcc ccgaaatctg accaccttaa ctttaaggta tttattcatt tttaaaaact 102601 aaatattttt cggcagtcag aactagagca aagataaatg atcccaggac tctgtttagc 102661 aggcagtcag gaagtgtgac agtgtggtgg gtggcagccc cggccaggcc tttcctcttc 102721 cctaaactgc cacagcagga ctgccacact tgggaatccc agtttccatc tgagcagccc 102781 ctccagagtt tgqaaggagt cagtgcttta gcctgaggag ccgtggatgg ctctaacact 102841 ttgcttgtcg gttgaataaa aatcaaccca aaggtggcct acactcattg aagtaggaat 102901 gccagaactt cagtggtgtc acatagaaga aaatatctaa gtgcttaggg agatggcagt 102961 gctagtggat ctactggatc attaagactc actcacccac ccagcgcagg tctagaggac 103021 acacccttgc cacactggga agtgtaaatg agctccagca tctttatttt tttttatttt 103081 ttatttgttt tattatactt taagttttag ggtacacgtg cacaaagtgc aggtttgtta 103141 catatgtata catgtgccat gttggtgtgc tgcacccatt aactcgtcat ttaacattag 103201 gtatatctcc taatgctatc cctccccccg cccccggtgt gigatgtccc ccttcctgtg 103261 tccatgtgtt cttattgttc aattcccacc tatgagtgag aacatggggt gtttggtttt 103321 ttgtccttgt gatagtttgc tgagaatgat ggtttccagc ttcatccatg tcccgcatct 103381 ttaaaaaaaa aaaaaaatct ctaagtggtg gctcttctct gtagatcagg agctgtagtg 103441 agcaatgcta caaaactgga gtttctaaat acagggggga tggtgggatt ctgaggaagg 103501 acaggccacg tggtaacact tacaaaagac caagtgggtg tggttgccac tgtggacggt 103561 ggagccaaag cagtcctcag aatagtctga cccccagagg tctttggcat tggctggttg 103621 atcatggtgt ccctggaatt gaaatagaag gacggtctac taaattttta cctgatctgt 103681 ataagcagaa gagttctatc tctagtgaac agaagtctaa ctttagtcac cagaactgag 103741 agtcaattca atcaattccc agatttgaca tagtttatag acctagaacc ccttgaatga 103801 aaggtaagct ggctcccctt gaggaaggac cctgttacat ttccggcatt ttattctgat 103861 aatctttttt cccagccttc cccaaagcaa cttagggcca tttaccaggg aaagccatgg 103921 aggaaaagga aataattagg ctatttggag attocaggac actggctcta cgctgacacc 103981 agttctaaga gacccaaaat atctttgtgg tctaccagcc aaagtagggc ttcatagagg 104041 tcaggggtca ctagagtttg agctcaggtc tgtttcactg tgagtctaga gggtccctga 104101 acttatccta tagttattcc cccagttcca gaatgcagaa ttgagctgag agcagtggct 104161 catgcttgta gtcccaacac tctgggaggc gaaggtgaga ggatcacttg agccaagcgg 104221 tttgagacca gcctgggaaa tatagtgaga ccccatcttt taaaaagaca aagaaaaata 104281 aagaaaattg acatggaaaa ataatataaa atgtgaataa tctcacatct actaaagaaa 104341 ttcaatctgt aattagaact cctcccacag agaactataa gcccagtgcc cccatcaact 104401 ggagaaacag aaagaaacaa tcttcttaac agaaagcata attggaatag agatactctg 104461 catcggggaa gaatccccat attgattctc tgatccatag agtgaaggcc aagtggaagc 104521 ctttggaact ccctctacct gccaagatac taaacaaaac aacactgcac gtctggagga 104581 attgtagcaa gaacttgaaa gatgaaggat gatgatgtcc acctctctcc attcagctca 104641 cctatctggt ttgtgcagaa gacaaatagg tgttggaaaa tgacagtgga ccagtgtaaa 104701 cttaatcagg cgggggctcc agctgcagct gcaggatcag gtgttgtttc atttctgcag 104761 ctaatcaacc cttctcctgg cacctggtgt gcagatggca atttttcttt tctattatct 104821 gttagtaaag actatcagaa gctgtttatt ttcagttggc aaggtcagca atacactcca 104881 agggaagagc agtctgtctc agatcttacc gatgcctggg gatagggagg gagtggcccc 104941 ctcaccgtct ccaaggccta gtcctctgct cctgctactg gcagcaaatc cacgcaggtc 105001 tgcaacaacc tcaattcctg cctcctcaga agaaagaatt caattgaggg acgtaagaca 105061 gaaggagaga ctgaggcaag ttttagcaca ggagtaaaag tttatttaaa agctttagaa 105121 taggaacaaa aggaaggaaa gtacacttgg aagagggcca agtggacgac ttaaaaagca 105181 agtgcgtggt ttgacctttt gacttggggt tttatacgtc agcatgcttt cggggtcttg 105241 cgttatttct cccctggttc ttcccttggg gtgggctgtc ccatgtgcct gcctgagccc 105301 actggctcaa ctcctgagat cttataggga aactactgct caccagtttc gagtgttttc 105361 tatctattag gagccggctt ttccctgttg ccgggtgtga ccaattatta ctttagaaag 105421 acagtcaaca accgccagac catcacctga tggtcacctg acactcctgg tgtgtggggt 105481 atggggagcc ctctcctgcc ctgctctttc tgactagcta cccactataa cactcccaga 105541 gggacctgca cattttgtgc tctttgcaag acagtgcctg cccagcacct gtaggcctgc 105601 tcaccccttc agggtcatga tttttgcttt ttaccgcagg tacccataag caaaacatgg 105661 cattgttcac catgctttta cattattcac ataattttaa gttatttaca caacaatgta 105721 aaaccatggt aaaccatgcc acatgttgct tatgggtacc tgtggtaaaa atcctgctac 105781 tagctcattt tgcagcgtct ataatgacag gtaatgctcc attcactcct ttatgacact WO 00/09525 PCT/US99/17712 EPI-109 1130 105841 tgcaaaaact gagaacataa cgcctcccag ttaagcaggc atctaaacaa tgtgaggaga 105901 acagaaatag accacgctgc atttatctct cttgatgaca ggcattgaga tttccacttt 105961 ttctggtttc ttattatgtc tctactgggc attottacat acatcttgca cgccatggaa 106021 agtttctcta gggcagtggt tcacaaactt tttggataca gaataczttt atgtgcttga 106081 aaactgagga ccccatacag ctttagttta tgtgggtgta aggttctagc ccaaactgaa 106141 gtccgaaggg agttggtggg tgggtgaggg gtagctgaaa aaacacccga ggaatcatag 106201 gcagtttgaa catggcctca tcctctctct gggcacgagc catatgtcca gtgtcagcag 106261 ggtaattata ccttttacag acaatagagg ctctgaagca atcacuagct cacgtgagtg 106321 gtcacctaat gcacctcaag tggcatggtt cataatgtgc ggagtcatgt gcctacgctc 106381 caaacccact gagtcatggt gcaccaaaaa gtggcctcag cctgctcctg actaaaqcgc 106441 agccatcttc cttacactcc acccctaggc caggggcatc ctccaggtag ggacatgtgc 106501 ccgtagggtg gagccctgaa tccataatcc acagcaacaa tacggagagc aacagctcat 106561 gactaggatt ccagctatgc tacttatgac tatcagggcc cagcgtaggc cagagcccag 106621 ggatgtctac catctctgca gggggtcatc agtaaggctc ttgactacct taatctcctg 106681 tgagacccct tgcagggctg ctgttatgtt ctgccaattg tcagggataa aggtacaaca 106741 ttgtgttcct aaaagggcac aggtgcctcc ttaggcagca gttactatgt ctaagaccat 106801 tcggtttcgc aacaccacct ttctgatctg atcaacctca tccataatg ggaagagggc 106861 cactcaggtg taattcagag cctgagcagc atgctctgca agagcagtaa cttggcttct 106921 acagttgtga cacacactcc agggctagtg cctgtcaagg ggtaaaacca ccagggtgct 106981 cattacactt gcaaaaaccg agagtgtagc acctcccagt tatgcaggca tctgggcaat 107041 gtgagaacag tggcaggtac atgaggccac cctcaggtat aatgtccagt ccagtttgct 107101 tataggtaag gccaccctgt gtccccacag acccataaac tcccaggggg cacacagtcc 107161 atcgaggccc cttggtgggg ccgcgtcttc caccatacct ttggtgtggt gacatgtatt 107221 atgcttacac acactgtgac gggtacccat cccacagtgc tattacccca gtgttgctat 107281 atgcaccaca gtgcctgggc caggggtact gcacgttacc tcactagcca gccccaccca 107341 tcataaatgc tatgggccag ccagggaatg gctgtgctgt gggtcttgtg gcatcctttg 107401 tccaaaactt gccacgttgc gttccaggca tcagccatgg gaccccaagt ctccagccat 107461 gtctggttct ctgcagatgc tgaatgtatg tgctaaggca agccatctgc agctgctaga 107521 agggcggtgc agatccaaca gttggaaaca ttggtcactt cagtgtaggt gtgggcccag 107581 tccacaatgc agttggagca tgttaaccta cagttggaat gacagagtag gcataggtac 107641 taacagagga aaatcacatc cctcaggtaa aatacaggct aacctttcat ccctggataa 107701 caatgcagcc cccaaggggt tctgccctgg gcaatagtac cacacctttt cagctcccca 107761 tggttccttt gggtcctgta ttcatgcgaa agtcacaggg gagcttgtag taggccacac 107821 agacagtaca tttgaaccct ggaggaaagt ttcttccctg gccgttttcc tacaaacagt 107881 taacttcggg gaccattcat tgaacaccca aagagtgaca tacaagtcat actgtaggcc 107941 ctccccacag ggagctacga tggacaacca ccagcagccg ggggcttgga ggggctatgg 108001 ccacagccag gttttctgtt cccctgcctt cagggacgtt ggggcaggca acaacaggtt 108061 actgttcatc cccatacctg gtcagaggcg gttacccttg gtgtgtatct gcaactgaat 108121 aggggtggtg gcccatgtaa caaagcctcc acctgggctg ggctgctttt ccatggccat 108181 tcattcaagg tttggagcat caggtccagc ctggaacttc agccctgcaa agacaggagt 108241 gtgacatgca agtaaaaccc attcttcaag agctcgctat atcactcaat catacccaca 108301 gcttgcaagt tgtgcggtac atggaatccc tactttatgt ccattgttgt gcctgttgtc 108361 cagtaaaatg tgtcccccat cactctcaat gaccaaaggg caaccatata gagcacataa 108421 gtgttgcagg gtctggatgg tgtgctgttg gttggccacc ctgcaaggat aggcaaacaa 108481 caggcctgtg gctgtgtcca cagctgttag cgcatgagta tacccttgtg acttcggcag 108541 cagcccaatg tagtctactt gccacctggt caagggcact tgccctgttg tcacttgtgt 108601 agcactggac agctgcctcc atttagggta tgcctgagca catgccgggc atttctgaca 108661 agcctcccaa atgtcttgca tgggcagaga cagaccccaa catttattga cttgttgcat 108721 cagtttaccc cctgcatgtc ccagtttccg gtgtagctac aaggccacat ctcatgtaga 108781 tgccaactct aaccatcgga ccttggccaa ggcttctgcc tcgtcattgc tgggggtggc 108841 cagaggcata tggcctgaca aatgataaat agttacatct ttgcaatgac ccatttccca 108901 gaggtcttgc tacatgggtt ggtggcccca aatgggttgg tggccaacta gccaattctg 108961 tattttccaa gtagttaaac acaaagttag gcctccatag actgcccagc tatcggtacg 109021 gattaccata ggtgtctccg ccttgttgat caccatccat actgctttaa attcagccca 109081 ttgactactt tgtccacatc tggtttcaaa ccatatggtt ttggtactaa gttggactgc 109141 aacactggtc caagcaggag tagcacctcg actagaccca tctgtgtgcc atgccccatc 109201 aggaatagag ggatgccctt ccttaaatgg cagtggctca gggtcaaggg gtgcctcagg 109261 ccccatggcc ttctcttgca ttaggactgc aggtcccaag acctcttgca actctgctgc 109321 taatgggctt gtgctcagcg tactctgttg ctccaagtaa gtgcctcact ttgccaaagt 109381 ggatgtctgc accatcccag tctggggggt cattacacat gaatgcaccc atcccgctgt 109441 caggtaagtc atccacactg tgactgtagc ccatcctatc acttctcaca agcctgaagg 109501 gcagcatata cagctgctag ctatttctct atcaaggaat accagagctc agctcctttc 109561 catagttggg accaaaagcc tcctggcatt ctcaggcact ctgtgtgctg ccacaggccc 109621 aaactaaaac catctgtggt cacatgcata tccagttcaa atgggcaccc cttgtcaaat 109681 acccacaggg ctcgtgcctg ctgaatagcc cacttggctg ccaggaagcc agtctcagcc 109741 acatcagccc aatcccagat tgctcccttc tttgttaact gatacaatgg ttttatcatt 109801 tgagctaaat gaggcaggaa tgtccaccaa tatcccagga ggctcacaaa agtttgcagc 109861 tgcctcaccg tggtgggcca gggatatgcc taaattttgt caatgatagc ctcttgtatg 109921 gccttcatct tacccgacca gataactccc aagaatttag caggtaatcc aggccctcgg 109981 accttggatt tgttgatggc ccaactgcat gctgccaaat gttgccacaa gaggggtgcc 110041 actgcttcta aatctgcaag agaatcagag gttaacataa tatcatcaac gtaatggaac 110101 aagtggactc cctttggaca ttttcaggct gttaaatcca tggcaacaag accatgacat 110161 atggtggagc tatgcacata gccctgcagc aacactgtga aagtccattg tcatcaaggc 110221 aaactgttcc tggctctcta gagcaaggtc aactgagaag aatgcattgg ccaagtccac 110281 cacatagtgg tactgtccta attccattgt cgagtggttc atcaaatcca tgatagatgg WO 00/09525 PCT/US99/17712 EPI-109 1131 110341 cacagcttcc aagccatuta aaatatccac ctccagaatg tattcaggta tgggagagac 110401 atacacagtg tataagcaag gagccaagtg gccaatgcca aggtacagag atacaggttt 110461 cactttcact gactggcctc cgtaaccttt aatatatgca gatttgccca aaaacttaac 110521 tgggttccca taaacaaggc tacaatctat gccagtatct accagcacca gcacccactg 110581 tacattggtg ggggaccagt ggattgccaa ttccacatgt ggcctctggt catctggtgt 110641 ccccccaagc cagacacctt tggccagttc cctagttgaa cagaaaaggc tctacatttc 110701 cacctggctg cagcaagtag tctctgagct gggtaggacc aggtcacaca gcaatgcctt 110761 tctccccttt gggcattttc cggaattgct gccctgcata caactgtctc cgcaaagtta 110821 ggagtatttc attgggctgc ttatcaattt tctctcagtc aaccccagcc aaaatcaaat 110881 ctatccacat ctgtgagcgt gtcactcgtt ggggccccct ttttttatgg gggagccccc 110941 tgtgggtggg gtaacttccc cttctttatg gtgtggaccc tccaatcccc ctgaaggcct 111001 tctgcttccc tgagagccgc catggcagtg gttacttcat gtatgcggtg ccctacgtat 111061 ggggtgagga cagcagctag ggagccaaag gggctcagga gcatcaaacc caacatgaga 111121 tccctcatgt gggaggtgaa acatttatca tctggccctc aggtattcag gacaaacata 111181 gcctgccgca tacccatctc ccgaatgact tacaccaaat tggcatatga ctgccattta 111241 ctcacagttt tgggcatttc accagcatta ttccacacag ttcatatggc tgcctgtagc 111301 cactcagtca gggtgtggtc tccttgcgct gccactaacc acctgctcac ttgcagccgc 111361 tgacagagag aggggtgagt catggtggag gccagcttgt ccatctcaga ggtggaatgg 111421 gagataccat ctgctccctt gttccacaga cgaagcatcc aggcaggcag gggttcccct 111481 ggacactggc aacactgctt gcctaattcc tgcaactcag ttggggtaca ggcaatatac 111541 gaaatgtgtt gcattatggt ggggagtccc tgagtccacc cttggagccc cagtggctgt 111601 tcatgatcta ccttctgtca gaccaccggg tgagcccgca acaggggttc ttcctccttg 111661 gtatgaaact gagtggggat ctccagacaa gatgatggac ccaggcctgc attcatggta 111721 gcctctaatt ccttttccaa gctctgaagc cacacctcca ggcatcctgc ctgcacctgg 111781 aggtccccat tcatggcagc ctctaattat tttccagatc ggtgtagcca gacctccagt 111841 ctgcatccct cagggactgg gtgtgtactt ttcttagcac agttaaaaat gcccatccaa 111901 ctctgccagc aaaggctctc tccttcttgg tgctctgcac ttccagctgc ttcagcgcct 111961 tctccatgct catgggggac ccatctactg ccacccaggt ttccactcaa gcccaccctc 112021 acagcacggc taccaccggg taccacaacc catgttgtgg tcacatggcc aacctggaat 112081 cagcagggac cgaaggctca cttaccttag gatcctgttc gtgatgccaa ttgtcaggtt 112141 ctagcccaaa ctaaagtcca aggggagttg gtgggtgggt ggcaggtaac tggaaaaaca 112201 ctcgagtagg cggtttcgac atggctttat tctctctctg ggtgcaagcc atatgtagtg 112261 tcagcagggt aattttacct tttacagaca atagtggctt tgagccaagc acgtgctcat 112321 atgagtggtc acctaatgca cctcacatgg catggttaca taatgtgtgg agttgtgtgc 112381 ctgcctccaa acccactgag tcatgctgca ccagaaggct gcctcggcct actcctgact 112441 aaagcacaac catctccctt agagtgggct aaatctactg ctatttatac tattagaaat 112501 tttaacacag aagttttaaa tatttacatt gttaattgat tttgaaataa taagcccatt 112561 acaggttaac ataattaaca tacttttatt aaaaatatct gtatttttta aaagaaaaaa 112621 aattagcaac aacagtgatc cttggaatcg tcccacctca gcctcccaag tagctgagac 112681 cacaggcgca catcaccatg cgagctaatt tctatatttt ttggtagaga tgggatcttg 112741 ccatgctggc cagggtggtc tcgagctcct aagctcaagt gatcctcctg cctcggtctc 112801 ccaaagtgct gagattacag gtgtgagcca ccacttctgg ccagaagctg gattctctgt 112861 cttgttctcc atccaatctg ttagactgtc aaatgccaaa taacctttgg aaaattctac 112921 tcgtaaaata aggagagaga taaataactt ctgagtatca tcattaaaat agtttgacct 112981 catggaccca ctgggtccca tgtggagaat agctctaagc taaagagtag aatggctggg 113041 aggggacata aacattcagc ccatagctgc tgaccacaat aacacatttt aagtctcttc 113101 ctctcctgct ccttgtgatt gcagacagac tcaatctgta ggagagctgt agagagaaca 113161 agctcaagcc cctgattttg cctacaaaga aagctgagcc cagcaaagtt aagggactta 113221 cccaaggtca cacagocaca cagcagagct ggggctgagc tccaggtgtc ctgctacaga 113281 ggccacttct ttctcccact agggactggc ctgtgattac ttcagaaaac aatggtcagc 113341 taactgattc tgaacgccct ttgctggtaa aagctaatct cctgaggaaa aatgtatgca 113401 ttggctgggc gcagtggctc aagcctataa ttccagcatt ttgggaggtg gagacaggtg 113461 gatcacttga ggtcaggagt ttaagaccag cctggcagtc atggtgaaac cccgtctcta 113521 ctaaaactac aaatattaag ctcggcatgg tggcaggcac ctgtaatccc agctactgga 113581 gagactgagg caggagaatc gcttgaaccc aggaggcgga ggttgcagtg agccgaggtc 113641 gcaccactgc attccatcct gggcaacaga gtgagattct gtctcaaaaa ataataatag 113701 taaaataaaa ataaataaac aaataagtat gcatcacctc aggtggtcag tcagctttcc 113761 caagacccca aagcacacaa tgttctttct ggtatgagtg acatggggtt cacagcacca 113821 caaagtccat gacttttccc tcagaagtga atgcatggct aattattttg tattttttgt 113881 agacatggag ttttgccatg ttgcccacgc tgctctcaaa ttcctggact caagtaatcc 113941 acccacctca gcttcccaag gtgctgggat tacaggcatg agacaccgca tggcctgcac 114001 ctatagtccc agctatcagg aggctgaggt gggaggatca cctgaaccgg ggaagttgaa 114061 cctgcagtga actgtgatcg ctccggtgca ctccatcctg ggcaacagag tgagatcctg 114121 cctcaaaaaa aaaaaaaaag tgaacacaca tgctggggaa gaggcctgca ggcacccctg 114181 ccagttctgc accagagcac actgtagcag ccctgctgtg atgcaggaag cagctccagg 114241 tcctgcagtc tgaagcatgg agcctgaagc ctggagcccc ccatccaatg ctgcgccatg 114301 ctcaccagta tcccccagca tcagcaccga ggcaccagct gcagataaat ttctcaccta 114361 aaatgttgag agatgttgct aaactgtcct tctaagggta tgtataataa tacggtcctg 114421 ccgatactga ataagactat ctgtttcatt acatcctcac aatactgaat atcattagca 114481 acttgaattt taaattgtgc taatcaatga aaatgattgc ctaattacta gtgagttgag 114541 gttatttaac attaatactc cttctgatga aatattttgc atttatcaca ttttacataa 114601 attctctcta tataattagc actagaatgt ccgacttggt tttcattgtt cctcacctgt 114661 ttggaaacac attaagaatg agggagagaa tggatggga ctcacctagg gatgcatgga 114721 gctggtcggc agccactctg aggccctctt aacacttccc caccacacac ttaatttccc 114781 ctggtttgtc catagataca tccaacaatt tttatataaa taagaaaac tcagctttca WO 00/09525 PCT/US99/17712 EPI-109 1132 114841 atggaaaatg gtaggttgga ttttatgact gaagtggcaa aaagaaataa gggattttat 114901 tatgggggag gtccaaaccc tggtgaaaaa cgaaattcat tgaaattgtt tgaaaattca 114961 aggattaaat cagattatZt tggattcag aggaattaga ttactttaaa gccccaggat 115021 actttattct gtagaataca tggaaagtat agaaaagaga aacaaagagg gaaagtcatg 115081 gctaataacc tggaaggggt aaatagggag ccaaaggcct gtgggacgta accaactcag 115141 cattccactg gaggctttat gatcaaataa caagctattt atcatgaatg caggatgtgg 115201 gcaaactcac gactgctccc actgccagaa ggtttgctga gggcaatcac ttcctggcac 115261 cgagctcctt gaggttatct actgggacat ctggagaatg cagtcttgca agcctactct 115321 ggacccagca gctgacccct tcttccatgc ccctcttcct gctatctctt ttgcctaata 115381 aatatggagg gctgtgtaaa gctcagggcc cttgtccact agaggcaaac tgcccgctga 115441 ccccttcttc caaatatgct cttttgtctc atgtctttta ttcccgcttt caccccactt 115501 tgttcagtcc ccctagggcc gtgtgggtta catagtggcg ccctgaacag cgacagaatc 115561 aggtgctcta caagtggcgt ccgaacacag ggactatgag gatgtgaatg aagaagatct 115621 gctggagcag aggaattgaa attgacaagg tgaatgggga tcccgggaca agtctgccgg 115681 cagcagatat aaggtcagtg ccctaaagag gtactgggag cagtgcctta aagtagtact 115741 gggaatggga agttttctga atcagggtaa catggggcag aattggtctg ttgaagaaaa 115801 acattatgtg cagttgctta aagttttgtt gaaacaaact ggtgctcagq ttagttctca 115861 cattaactac gatgctacag gaagtcatta tgcataaccc atggtttcca caggcaggga 115921 ctcttgatgt agaaaattgg gatagagcag aaggattaaa acaggctcat caaaaaggtt 115981 ttcaagttga ttcttcagtt ttctccactt ggagtttagt tcgtactgta cttctgccat 116041 tatctccttg ttattctgcg ggacagcagg ctgaatgtaa aaatctgaaa gaatctgttg 116101 tcccacccac agctccagtt gaaaataagt aataggagag ggaggataaa aattggccta 116161 taccgccccc tccagttgca gaaacatctg taccgcctcc ttcggtggca gaaacagaga 116221 ccccaataca aagaatttta cgctctgccg ccacggctgg agagccctta ggaccttgca 116281 cttttcctat ttccgtaagt cctgatccaa ataatccaca gcagcttaat catgaacaca 116341 ttccactaga gtttaagttg ttaaaggaat taaaagtgag tgtggtaaat aatggcatac 116401 agagcccatt cactttagga ttgctagaat ctatgtttgg tgctatgtgt cttttaccct 116461 ttgatgtgaa acacttggca tgaacttgct tgtctgctag cgcatatctg acatggaatt 116521 taaactggca agaacagggt gcagaccagg ctagacagaa ccatgctgct ggaaatggag 116581 acattacaga ggataggcta ttgggtaatg gcccttattc tgacctggta catcaactag 116641 cactcacaaa tgctgcttat cagcagtgca cacaggctgc taaatgtgcc tgggccataa 116701 ttcctgaaga gggagtccca gtactatcat ttttacatat catgcaaggg tcacaggaac 116761 cctacgcaca atttcttgca agattacaag aggcagtgag gcatcagatt cctcatacct 116821 tggctgcaga aatgctaacc tttactctag cttttgagaa tgcaaatgca gattgtaaat 116881 gtgcactggc accggttagg tgtacaaaaa cttgggaaat tttctcagag cttgttaaga 116941 tgtagcaact gagctttatc gatctgcaat gttagctgaa gcaatggcta atttagctgt 117001 tgacaaatct aaaaagagcc aagggtcaaa ccctaaaatg ggaaaatgtt ataattgtgg 117061 aaaaactgga cattttaaaa aggaacgcca ccagatctca ggacagaaag gatcttacaa 117121 tgcttttccc cccggccccc agcggaaaga acacctggac tttgtcctcg ctatgacaaa 117181 ggaaataact cggctaatca gtgctgctca aaatttcatc agaatggcac ccccctgttg 117241 ggaaatgaga tgggggcctg tacccgggcc tcacaaacaa tgagggcatt cccaattcag 117301 acctcaaccc tgtttcaggc atgggttccc agaggcatat tgagtccctc acccgaggaa 117361 ctccaggaag tgcaggatta gatctcccag ccagagaaag ggttacataa ggtggggaag 117421 acaaacccac caagattctc actggcattt ggggaccttt accagcagga tatatgggac 117481 taattttagg caaaagccac cttaacttgc aaaggcatta ctgtagtccc agaagttgtt 117541 gactctgatt atgaaggaga aattcaagta gttttattgt cacgagatct tcgggttttt 117601 gaaccgagag aatacataat gcaattatta cttattccct gcaaattaca cccttctcca 117661 tgaaaggaga aacaaggaaa taaagggttt gggagcacag ctacacggga aatctatcta 117721 tcccgaccca tagcctctaa tagacccacc tgtgtagtac aaattaaagg aaagaaattt 117781 tatgggttta tggataccgg agctgatgtg tcagtgttac cagcaggtct ttgttcttag 117841 agctcccaag atggcggcaa gccttttgtt ctctgacctg gagttcttgg cctcacagat 117901 tccaaggaat ggatccttgg gccatgcagt gagtgtcata gctctattag aagctcttcc 117961 aaaagtcgtg ctgctatcta tggactaaaa catactcaaa caataatgac ctctggcgtt 118021 taggctcaat gctcagagct aattgcagtc attcaggttt tacagctcac agcttcagat 118081 cctgtcaaca ttgtctgtgt tcagtttatg tcgtaaatgt agccggtcac atagaaactg 118141 ctacaattaa aagtacgcta aacccagaac tgctaattta tttttaagac ttcaacaagt 118201 tatttgttct agtgcagctc cttttcatat ttctcatatt ccttctcaca cacaacttcc 118261 tgggccgcta tctctaagta atgagaaaac agacaaactg attgcctctg tgtttcagca 118321 agctcaacca tctcatgtgc ttctgcacca aaatacttcc gcccttactc acatgttcct 118381 acaggtttgt attatattat gcagtatatc cctcgagcca cacctataga aggatgtaat 118441 ccacgaggtt tggctccaaa tgaaatctgg caaatggatg ttacacacac agcaaccttt 118501 gataagctga gctatgttca tgtgactata gacacttatt ctcatatgct gcctgctaca 118561 tgccaaacag gtgagacagc tggtcatgta cagcgacact gtctgtcatc atttgctcat 118621 atggggatat ctaaacaatt aaaaactgac aatggacccg cttatactag tcatgctttt 118681 aaaaatttct tgcagctttg ggctataacc cataaaacag gaattcctta taatcctaga 118741 ggacaaggca ttatagagca ggcacatcaa acattacaat gcatgttgaa aagacaaaaa 118801 gcgggtatag gaggccaact accacctcaa taaaaactac atttagcctt atttacttta 118861 aattttttga ctcctggtat ggatggtaag actccagcag aaagacattg gcaagtgtta 118921 gaagaaaaga ggaaaattta tccaaaagtg ttatggaaat ccctggaaga aggaaaatgg 118981 aaaggtctgg tggatttact gacgtgggga agagagtatg cttgtgtttt tacaggagat 119041 ggacaagccg tgtgggtgcc ctcaaggtgt gtgcaaccat ggaacgggag actagaggaa 119101 cccagggtgg ccaaccatgg acagggtccc cccggtacga gccatgagcc agctgagcct 119161 gagtgcaaag acggagagaa ggccaactgg agtcacaaca cagttctaat gttatatttg 119221 taaagaatat cactactcaa cttacagttt gtgtttatag atatagatat agatatagat 119281 atagatatgg atatagatat agatatagtt atagatatag atagatatac actttaagtt WO 00/09525 PCTIUS99/17712 EPI-109 1133 119341 ctagggtaca -atgcacaac ttgcaggttt gttacatagg tatacatgtg ccatgttggt 119401 ttgctgcacc catcaactca tcatttacat taggtatttc tcctaatgct ctccctcccc 119461 cagcaccgc3 tcccaacagg ccctggtatg tgatgttccc tgccctgtgt ccaagtgttc 119521 tcattgttca atttccacct atgaatgaga acatgcagtg ttttattttc tgttcctgta 119581 ttagtttgct gagaatgatg gtttccagct tcatccatgt ccctgcaaag gacatgaact 119641 catccttttt tatggctgca tagtattcca tggtgtatcc ttatgtcttt ttgacagcta 119701 agaaggacca gctccaggta aacaataccc aattgacctg taaatcttac caattatatc 119761 actgcattaa tcatagcaca ttgcaaacac ataatatctc tactttgatg attttaggcc 119821 acatccctgg gctatgtatt cctgttaatc tgtccgaggc ttgggctgcc acacctgctt 119881 tgcattttgt gaaacttctt ctaactgagc ttactcatca tgtctgtaga gccttagaca 119941 taataatttt agctattgtt tccttggtcg cactaataac ttctgttgtg atgtcctctg 120001 tagctttgca taattctatt caaacagctc agtacatgga gaactggaca cacacagccg 120061 accaagcatg gctacttcag aataaaatta acactgagtt acaaactgaa gtggtgttat 120121 gggaagtcag ggaccccaaa gagagggacc agctggagcc acagcagagg aacgtaaatt 120181 gtgaagattt catcttaata cggatattta tcagttctca aataatactt ttacaatttc 120241 ttatgcctgt ctttaatctc ttaatcctgt taccttcgta agctgaggat gtgcatcacc 120301 tcaggaccac tgttataatt gtgttaactg tacaaattga ttgtaaaacg tgtgtttgaa 120361 caatatgaaa ccagtgcacc ttgaaaaaga acagaataac ggtgattttt atggaacaag 120421 ggaagacaac cataaggtct gactgcctgc agggtcgggc aaaaagagcc atatttttct 120481 ttttgcagag agcctataaa tgaatgtgca agtaggaaac atatcgctaa attcttttcc 120541 tagcaaggaa tattaatatt aataccctcg gaaaagaatg cattcctgag gggaggtcta 120601 taaatggccg ctctgggaat gtctgtcttg tgcagttgag ataaggactg agatacgccc 120661 tggtctcctg cagaaccctc aggcttacta gagtggggaa aaactctgct gtagtaaatt 120721 tttggtcaga ccagttttct gctctcaaac cctgttttct gttaagatgt ttatcaagac 120781 aatacgtgca ccactgaaca tagaccctta tcaggagttt atgatttttc tcctgtcctg 120841 tttcctcagg agcatgtgat ctttgttctc ctttttgccc tttgaagcat gtgatctttg 120901 tgacctactc cctgttctta caccccctcc ccttttgaaa tccttaataa aaacctgctg 120961 gttttgcggc tcaggtgggc atcacggtcc taccaatatg tgatgtcacc cctggaggcc 121021 cagctgtaaa attcttctct ttgtactctt tctctttatt tctcagccag ccgacactta 121081 tggaaaatag aacgaaccta cgtgaaatat tgggggtggg ttcccccgat atgtgatgtc 121141 acccctggtg gcccagctgt aaaattcctc tctttgtact gtctctcttt atttctcagc 121201 tggccaacac ttatggaaaa tagaaggaac ctatgttgaa atactgaggg tgggttctcc 121261 caataaagtg gtaatgttga aatccacagt tctatggtta ggggaaaagc acaaagcttg 121321 caattgcagc agcaattgca ttgtcatttt aatcacactc atatttgtgt aaccaactta 121381 gaatataacc aaagtgagta tctgtgggac gttgtgaaag cccatttgca gggagctttc 121441 acatctaaca tcacctttga tattggtgaa ttacaaaaca aaattcttga tttacatagg 121501 caaattcaag agtttctgcc ttctttagaa gactggacca aattccagca aggcctggag 121561 agcctcaatc cttggactta tctaaggcac tacattaaca tcttacatgt agttcttgga 121621 ataatattgt tttgtctctg tcttctgttc atagcctgta aaattggatg gaccaccaat 121681 cggaaaatga gagctgccca ccctggcctt acattctttc aattaattca taaacagaaa 121741 gggggatatt tagggagcct aaggctcgtg ggactgacca actcatcatt ccactggagg 121801 ctatatgata aaacagcaaa ctgtttatca tgaatgcagg atgtgggcaa actcacgact 121861 gctcccactg ccagaaggtt tgctgagggc aatcacttcc tggcaccagg ctccttgagg 121921 ttatctactg ggacatctgg agaatgcagt cttgcaagcc tactgtggac tgagcagctg 121981 atcccttctt ccacgccccc cttctcacta tctcttttgt ctaatcacta cggagggttg 122041 tgtaaagctc agggcccttg tccactagag gcaaagtgcc ccctgaccgc ttcttccaaa 122101 tatactcttt tgtctcttgt cttttattcc cacgtttgcc ccctttgttc agtttcccta 122161 ggtccatgtg ggttacatag tggcaacctg aacaatgaca gaatcaggtg ctctacagaa 122221 ataacttttt aaggaaagat ttgggactta gagaccccag gagacataca caaaaatgat 122281 aagaggatgt gcccaaacca gtcttaaagt tgtggcacag ggtgaggaag atgaagctgt 122341 tactgaacct cagagagtga ctggtgttac agcaaaagtt agcaatggcc tgaagggagg 122401 gtttctgaaa tcaaatatga atgattcccc ctcagggaac ccaaccttgg gaactactgc 122461 atggttctct gtatgggaaa atatcattaa tgcaggataa attgtgaaat atcacaggaa 122521 gcatcctgca tctagtcaat cttctgtttc tggggtggcc tgtgcagctg tgcaggcaga 122581 ggcccaacca tcctggtgag tggcacacag ggactgagat ccagccacac ctaccaggcc 122641 atgctctggg aagggggtgg gacctgggca aaggacacct ctctaggact gcacagaagc 122701 ctttgtgggt gggtgggaca ttcctgtgat ggccttctgg ctgggcacta tgaaatgctc 122761 tgaagatttt tccttgcact gttgcactaa ccccagtcct ctatcactgc cccttcctcc 122821 tgggcgactt cactgatgtt gtggccatgt gaattctctg gccaatgaaa tgataaagat 122881 gatatggcct ctgccaagca gacactgtaa gtattattgt atgatgcttt tgtctctttt 122941 tttaaagtta aagcagttta ttaagaaaat aaaggaataa aagaatagca ctccataggc 123001 agagcagctg cctctgtctc ttatattttc ccctctgcct caagcccaac atgcccaaaa 123061 ttggggctgc tggttcagcc tgggtctcag aataaagaca tgagccacag atccattgct 123121 gacccatgat ggagatggac acaagagaga aacacatttt tgtcatgtta gccactaaga 123181 ttttgatttg gaggccattt gctacagcaa tataacctag cgtgaacaga gagacacagc 123241 gatgttccat ttcttttcaa cctggaacag gagaatttca taggtgggcc tcaatttcac 123301 tttagtatct ratttagaca agaaagttca tactgttcaa atgtcatgtt taagagtgct 123361 ggcattatca ctgctgtggc taccccatca gatgttgctc actgactaat cttctcatgt 123421 tagtgaggat agacaacata tcaggccata attcaaagta gcaaatagga aaagagcttc 123481 atcctagcat tatgggacct taattaatgt cctttcctga caggtttcag aggcttttgc 123541 aggcagcagc agagctattc atctcactga cagtggggaa catggccaaa tggttgcccc 123601 cacaatggag gcagagtttc aggacacttg tctgatctct gcccttgaag gaacagtctc 123661 accctgattg acacttttgc ctgttatgtc caaagaacca atggaaaagc aggaaaatta 123721 ttccttcttc atttctctct tcattattta aaattattct gtcttcactt ctctctcctt 123781 ttctctgct-t cctacttagc tctttagaaa tgcaattata atcttttatc tccccttcac WO 00/09525 PCT/US99/17712 EPI-109 1134 123841 cagacactcc caacagggca agttcatcta actatgtgct ctragzzaga cgctacagag 123901 cagaactctc tcccaccaag agactacctt gagacataac agtcaattca caagccaaaa 123961 tatgcccgct atgaaactct cccatctgga aattttttgg ctgctzttac aacctagttt 124021 tgcccacaaa ggcaccagca gtaaccaact caactgcctg gtagacaagg caccaaagcc 124081 agtacccaga ccctctacct gctcacttcc tgccttgcat gccacgcccc ccatttaaaa 124141 gcctctgctt tctgctccaa aggtgaagca gttaccctta aggaaagaag cctgtacttc 124201 ttcccctaag gtagctttgg aataaaagtc actttatacc aaacctagct cttgttaatt 124261 agactctgca agtgatgagc aactgaacct acatttcagt tataattcct atgcttgttc 124321 ttcctgccct gccttgggga cacgcacaca ctcccaggca catacatgca cgtgcactga 124381 gacagctatg tgaataacca acaagatccc cttaggaaaa ccggtgcttg gcctggcctt 124441 aaattccaga cccttgggca tcatacccaa gactgcaaga aagaggaggg gctggacctg 124501 aaaaacttgg aagggaaggt ccaactgtac aggtattttg tcaggcatgt gatttcagta 124561 taaaattcta gaaaagatga gtgacacttt ataaggagag aatatcaaca aaatttctca 124621 ttttacttct tgctaagacg acagcaggga attgtaagca gatggatggg caatccccac 124681 cttcagcagg ggaggccaag gccccaacac acctggggag aagagctggg ggcagtgaat 124741 ggctgaggct ttcttgggga gctgggccat cttcttcggt tttacttcct gaggaattca 124801 caggcttcca ggagggctgt gggacacaac agagcaagag attcagaaac tgatttcttc 124861 cattaaacca gttatttaat ccaataaatc aaagagaata ctaagagttt tctctgccct 124921 tctcccatca ctgagtcagt gcttgccaca ctcatattcc cactccccta ctcctagcga 124981 ctacggtgtt caagggagcc agagtctagc cctcaccagc cagggtgttt ccctgctctg 125041 gcctgagaga cacaaccacc ctgcacttgt ctctgattga atcgactgtc acattctcaa 125101 gttcacaaga cattggtggt cctctagctt ctcccggaat gtgaacctgt ttgcaatcat 125161 gttcacctgc agattcactc attcattcac agatccttac tgagcacctg ctttgtgtga 125221 gttgctgtgc taagtgctgg ggacacagca tggatagact ggcctgccct caagaagcat 125281 gtggtctatg cagtcctgag ctggctgctc acaagaagag ccctgtagcc atatttctca 125341 gagggtggtc ctgacctgca tcacagtgac ctgagttgtt tgtcaataca gaaaagggtt 125401 tctcaacctt ggcactattg acatttgggg cctgataata accctttatt gcagggggct 125461 ggctgtgctt tgtttagtag catccctggc ctctacctat ttgttaccag cagcaccctc 125521 tatgttgtaa gaatcaaaaa aatgcttctc acattgtcaa atatcccctc aggggaaaaa 125581 ttgtctctca ttgaaaacta ccgataaaga catttctggc cctgccccca tccttggacc 125641 aacagcatcc ctaatgcccc caactctggg tgagggacca ggaataggaa tctgaatgat 125701 tgcagtgcac agggagctgt gcacactgaa atcccacagt tatcaccggg agccttacaa 125761 tactctgtga tgtcttctaa atatttttaa gggattaaat taatatcaac atatttccct 125821 ggttaagatg tgttttccta cacttgaatt tttttgagat tttgttttct ctatagttgg 125881 catctatggt aactgtctag aatcagattt tttttttttt ttttttgagg aagggtcttt 125941 cggtgtcacc taggctgtag tgcagtggta caatcatagc tcactgcagc ttcaaccttc 126001 tgggatcaag caatcctcct atttcagcct ctcaagtagc tgggactaga ggtgcttgac 126061 accacaccag gctaattttt aaaattattt ttgtagaaca aggtctctct gtgttggcca 126121 cattggtctc aaactcccgg gctcaagcca tcctcccacc tctgcttccc aaggtggtgg 126181 gatgacaggt gtgagccatc acacctggct ggttttgtca tttctcaatg catatgtata 126241 tatgcacctt tcattttact gaataaaatg gattatcagt ttccaaagat ttcatgacag 126301 tgccgtcact atccgtacta taaaatttat aaaaatttat tacatactgc tctattttat 126361 tctctaatta ttttatcaat gagattataa tttcctgaac tgtaaagaga tattatcttt 126421 ccttaacatt tttacacctg tgttcgttcc tagaatgctg tttggccctc aaaccttgac 126481 cttcacccat ggtggtttct cggggatgct agctagggtc tacttacggg aggttgagca 126541 ctttttcaga ttagtaatgc ctgcgacata ctgtggtccc aaatattttt catatgttgt 126601 tttgccatgg agtctggcca gacactcagt gttgtcattg aacagaaggt ttttggtttc 126661 agactggaat aagcaaaact tgtccgggca gtcagatcca tttctcccaa atttagcctg 126721 cgacaaaagg gcagacagtg agtagctaag gaaaagagga atttgtgggt taaaggaggc 126781 aaaggggtat ttcttccacc caagaacagc cctgagaaaa ccatggggca gaaggagctg 126841 agttctggag tcattccacc tccttagtgg agtcccccac cccacactcc tggtggcagg 126901 cccgccttgg gcagcatcca ggcctcacac cacttctggt cctacctcct accatctgcc 126961 atctttcctt ccttcttaac ctgtgacctt ttcccataca acttcttatg ggtgacaagg 127021 caacaatgga ggggttttga gatctgccct cacaagtcaa ttgctcagga cattctaata 127081 tgcagctctt ctagagaggc aggctgctag gaaaacccag gctcagccac taaccagctc 127141 agtgtgcagg tcggtcaccc tgcctccctc acacagttcc tgctctgtcc caggctccca 127201 tgtggggaga ctgagaccca aacccctcag tcacggcagc tctctcacca gcaccactgt 127261 gtgtgcacat taagagctcc ataaaggcca gttatggtgg ccagtcttgt tattcctgag 127321 ttgttttctt caaaagcaca cagagacaig atgttatatg ataaaaatag aagttctaat 127381 aaaatcccag attttaagaa aattttggga tttcgttcaa atcacattta gagagcccta 127441 aatctatagg gcaccttctg agtttgctgt tttagaggcc tggtctagag cactgttcac 127501 tcggcccagg ttcaggaaat gtcacctgag taaaaagcac tatactaatg catgtgggag 127561 gaaggctcag tggcttcctc atttgccaga agaacagcag gagggaaaaa gacagcctct 127621 gagccaggca gtgatggcaa caaggccagg gcacagagtc tcagcagaaa tggagtgagt 127681 cccagaaagc ccagagtcaa aagcctctgt tgttcttgtt gacactctgg gcaacgccac 127741 agcatgaagc caatactctc accatgagct tcaagtagag gactagagag gatcgagtgg 127801 gctggtgcac ctagctctgt gatctcctca cctaacatga gcccacacag ctaagaaagc 127861 actagaagcc ctgtggtcca tacctgttgg tggagcaaca cctgtttcag gcgttccacc 127921 ttatccatcc gagacaccac ggcatgattc ggggccatgg caagatggca gcttctagcc 127981 tcagtcacag gcttccgttt gccatcgagg cacagcagcg caaaatctgc cagcttcaaa 128041 tccttagccc atgcgtcatt gttatttcct ggggagaaaa agaaggtggc atcatccacg 128101 cctcccctgc ttagccaaga agtctcttct gggtgggtgt ggccattcca ctgacctccc 128161 aaatgcacac actggggttg tggtgatgtg aggaacagag aaggagcttc atcctacaca 128221 agctgtacaa acttcaaata taccaaatat tagtgctgtg tccargcaac ggaatgttat 128281 tcagcaataa aagggagtga agttctggta catcctgcaa tatgcatgaa cctcgaaaac WO 00/09525 PCT/US99/17712 EPI-109 1135 128341 gatgctaagt gaaaqaagcc agtcacaaaa gaccacacaa taggctaggc acggtggctc 128401 atgcctgtaa tcccagccct ttggaggcca aggtgggaga atcacttgaa gctaggagtt 128461 catgaccagc ttgggcaaca tagcaagacc tcatctcaaa aaaaaaaacc caccacatat 128521 tatatgactc catttatatg aaatgtccag aataggccag cctatggaga cagaaagtgg 128581 attgatggtt gccaatgctg aagaaggata gggcaatgac tgataatagg tgcaagggtt 128641 tctttatggg aggatacaag cgttctagag ttggattgtg ttgatggctg cacaactctg 128701 tgaatgtgct ggagatcact gaattgtaca ctttgcatgg gtggatctt tagtatatga 128761 attctacctc aataaagctg tttagagttc ttattttttt aaagaagaaa accctccacc 128821 tatgccatat ttttcagtga gttccagaaa aagaatagat ggtttacatt caaggagaaa 128881 ttggtttctc ctccctttca tattcaaatg ctattagtgt aaccagagaa aggaaaggaa 128941 cttttatagg tttatcaaat atatacagcc aattctaaca aaatacagtt gtaaagtacc 129001 ggagaaagtt aaaattaaat ttgacatcaa tctgatccct ggagattact tcagttaatg 129061 gcttgtaaat tctaaatgta attgtatgca tgtctatgtt tgtgcagatg ccggctcatt 129121 gttccggctc ccgtttgtct ctctgctctc tccctttaag aaagcacttt attcattctc 129181 ttggattcct ctatttgata ttgaaataat ttcaaattta catgtcttgt tttaatctct 129241 gtcccaagag acactagaag gagcagaagc agaagggaga agtggctgag actgcagtga 129301 ttactgaagg agggaggccg aaagtggaga cagttctttc tcaggaaaca gaatagcaag 129361 tcacctgctg agacttgggg gttggaatgc tgaagtgggg ctaaggagac agatgcagat 129421 tggaaggtag caaatggctg aggaccagga gagagagtga ttgttcaaac attggctgga 129481 agattatctt ccatcatctg caaccacctg taattttgtt cccactaact cccaaggagt 129541 ctccagacca aggctcacat ggggatgaat gaaggcctct acttcctttt tcataaaggg 129601 aggcttcatt tgcatatgtt cacccagttt gtagcatcat ccacagtttc caataggcat 129661 gcatgatctc atgtgggcag acagtgtgtt tctgtggttg actagaggaa gccagggaga 129721 catttgctac tgagcatggc tagtatctgt gtgtgtgaga gtgagtgtgt gtgtgtgtgt 129781 gtgagagaaa gagagagagt gtgtgtgtat gaatttcgtt tcaaaatcca tatgacacct 129841 acagatgtta tcatgttgtc tattgagata aagaattttg gagttctttt aatcacaaat 129901 atggaaaatg ttataaaacc ttcccaaagg caaatctgaa cactaagatg tgttgtgatg 129961 ccaaagactc tgctttgaag gagaaaagga aacaccttca cctaccatca gtgttctgca 130021 agacagtgac atctttcaca aatgcaacgt ctccagcatt ctcagccagg cacctaaaat 130081 gttccagaaa atatacacat aattacagaa gagaaactag tggggctttc ataaatattt 130141 gtaatatgca ttccaaaaac tgaaatatgg aagtaaacat ctaaaagaca actatttcta 130201 ggaatttact gtttacagcg gcagattgaa cacaggtgta cctgccctcc ttttaaaacc 130261 ctatataaaa gacattacaa aaccaagaaa tctaaagata tgcgacccag gaaacaggca 130321 atctaacatg aagtaagaca aaggaaagca ccaaaataat ggtcaacagg acccccagga 130381 ccacagatgt gcaggcggcc tacacagcaa ccagtccaaa ctgcagcagg aagatggatg 130441 ccttctggag cagcacttcc aagtaaatga tgaaactgtg atagcaccca gagagagaga 130501 gagagagaga gagagagaga gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt 130561 gtgtgtgtgt atgcatgttg ttaggagatt tacattactg gcagacagtt tggggatgag 130621 atagtgatgt gtttttttaa gtgcagaaaa ttaagcaaat aagaaaagac atttatgaac 130681 tccagagtaa acaaaaagtt tgtacaataa gggaaatata atatgagaat aacgcttaca 130741 cagtcataag tactgaatat gacattagcg tgttgggtgc tgaagagagt tgaagtctgt 130801 ggttgtgtgg tggaaaaggt gctgggggca gtgtgagagg ctagatcttc ttctatacta 130861 cagagtcagc agaaagttaa aaattaagaa ccagcattat aaggatgata gaaataaagg 130921 ggtatgacac tggtttcagc ttttaatgat tttgctataa atttccccaa tctagattct 130981 agatataatt taaacaaaag acaagggatt ttcttccagt ataattagga atattaaaat 131041 gtgggtgttt ccagtgaact aataccttgc tgcaggtctg aaaaaaaaaa aaagaggagc 131101 acatgcttct ttcgggctct tatgagacat gtgttcagca tttctgagta gaatcacatt 131161 tccatttgca aatccttagt cccttaaaga tatttttata cattcacaaa acattttttt 131221 ttgttttggg tcttttttta tgagccactt atatagcaaa agctactttt ctgtcattcc 131281 attactggaa caaggctgtt gaatttatat taaaaagttc agacaccctc agacacatga 131341 cgccatctgg tcgtgaaatg tactcttggc aaatggagga aaaggaacag gggaagatcc 131401 tctctgcacc cttcacactg gtaaatagtg cccctgagaa gcaacacccg gatgaatggt 131461 gctgtaaaac gtggggtgtg gttacaagtc actaagtggt tataacttat gaattctgaa 131521 aacttgtttt ttggcttatt tttcacttcg ttactggaga ataacactgc aattctgcca 131581 tctctttgcc atttctaagg ccaaagtcag agaaaaaggg aaacctaagc catagtcatg 131641 acctaggtga gaagaaaagg ggcggcgatg ggaaagagaa ttcttcccca taaatggaat 131701 tgtaggaagc acttaggata ccacactcta cccatttgat tttcaggacg aggctattga 131761 ggcctactgc tgttgatctt ggctcaaagc cacagggaga agcactgcgg agctgaggtc 131821 agacagccct ggtgccagcc tccactctct ggggcggtgg gtgtggtggg gacagccctc 131881 actggggcca cccatgagct gacccacagg atgaccccca ctctgctgtg acaggtcaca 131941 tctggctcct tagaactgca atgctgacat gctgagggat gaggtaagtc cccatcctga 132001 tggagctcag tcacagactc accggaaagc cccagtgtag ccgtagtatc tctcgttgct 132061 gttgggcacg cacttattct caccctgctc gtcgccaata cacagagcac agagattaga 132121 tctcgggtca gacccagggg cacagctttg actgaaatat tcatctggag agaaggaaca 132181 cggggagtca gctcttcaaa cctgagtcca cacaagcaac ctttacctaa cagccgatgc 132241 agggtggttt cagttcatta gacttcccag gacagcaatc tagatagaac acactcacca 132301 tcacaaagca acatgttgtc accaacatag gacccaccag aaaagcttca ttcagactgt 132361 aggcacagat ggacacccaa ctaaggctgg ggatgagagc tgtggctgcc tggagggtcc 132421 cgtcatcaca gccttgagct ggggactcag ctcatgaccg tgatggctgt gtgcagcaga 132481 gcctgtgagt tgcctagtcc aggatctgat tttgttttta tcagtaatgg aaaccctgct 132541 ttgtatctgg gtgcttggcc ctttggtata aagactagac ttatcagact ccctggggct 132601 catatggcca tatgggtagc tataggccag tgaaatatca gcaggagtgt tgggcgccag 132661 cttctcagaa acatccttga aagacaattg gtacatgcct tttgcccttt cttctccttc 132721 tctttcttca tcctgcacat agaatgcaga agcagggact ggacttagag atgcaatgtg 132781 ggccatgagg tgaccttgag catgaaagcc acacaaatgg cagagtagcc aaatgattaa WO 00/09525 PCT/US99/17712 EPI-109 1136 132841 agcccaggtt ccagacccca tattgtcttc ataccagccc taggcaaacc acctctggac 132901 tacatgacac agaaattaac ttctgtcttg tttaagcctc tactatttca ggagttttct 132961 gttccttgca gctgaaccg atctgaattc gttcattgtg tgatttaacc caagaaagaa 133021 taaacaaagg tgacaagaaa gctctgcccc actgagcaaa cgtcacccat tatcagactc 133081 ccactgctgc :ggaagagcc acactatgtg tcaacctcag gaaaagctgg gagttcccat 133141 tccatcctgg cagtttccct acagctcaga ggctgccatg gagctggtga ggagcagagc 133201 cacgtgaaag ctgcctgccc cggccaggat caaaaaccca tgcagtggag cccctgccct 133261 aggagacgcc catacaaaa gggagtcaca ttgaggatgt gctacacacc atgccacggg 133321 gcccacagca agcagggtgt ggctgatgct gactaggatg agtgtggggt gtggtgggga 133381 gagaaaactg cagaagcagg tggagccagg ctcttgaggt cttattcagg ctccgttgca 133441 gtgtagagta aacgtcagtt ttgcttagta acaggagtca cctttcatga ggcaggcaga 133501 catctttccc caagctggga agccagagtt taagaggaat ttaggtctgg agctccaaga 133561 ggtaaaaagc atttgcacat cttggaactt gcatttattc ttagggtgca gcgaaatagg 133621 cagatattcc aatctttaat cttggggtgg ggtgaatggg gcatgggaag tgctgtgcag 133681 ggaaaccccc agtgcaccca cgcctccagg gggcagccac agggagaatt tccttatgct 133741 ggaagaggcc tgcaggccac tatcagcctg caaatcccct cccctccctt ccctaaggtt 133801 ccacagcaca atatgcctac cctccagggt ggcccaccca ccgcaccttt ggaactcctt 133861 accaaatttg caggagcccg tctggttgaa gagcaggccc atggggatat tccagcctgc 133921 agtcctgtcc acggcggtgt ggcaggactt cttgcctttc acagagttcc aggtaaggct 133981 agtgtctgat ctcctaacca ccgccacagc aagatatcct ggcataacag atgacagaaa 134041 aacaagtctt aacctccagg aggcctggca catggattcc agtggagctg tctacagccc 134101 aggccaaaac aggccaagaa gcaacaccag gcaatgattc cctcaaagaa ctggcctttt 134161 taggtagacc gagaaagcat aagctgctgc cttatgttaa ggtgagattg atgaaataaa 134221 acagtaagaa aagctgatta ttttagtgat tacaggggac tgtcttcaac cagccacaca 134281 atgtccctga gttacaaacc agcaatgcat ctctcagtgt aagcttctac agcaacaaac 134341 actataaaca acaagagaga ccccaacagt gcataaatca ccaaccacag tgtgcatcag 134401 gcaagagcac caacatccag ccagctaacg gctgtgtggg tacaggggca catgtcccca 134461 gggactgccc tgagctgagt ctgaacccac cctgcactgg ttgaactcaa catggttgcc 134521 gttgtcctcc tgagagaatg catctgacag acacccacca agggcaagtc ttttctgaaa 134581 ctgagcaagc accagctctg gtgggcagga ggagtggtgc acagagcact gggacacgag 134641 tcccaggtca cgaggacccg gggtcaagac caggatctac cacagtatta cctatggctg 134701 tgagtgagat cctgggcact tggggactct cggtgccact gtttcctcat ccccatgagg 134761 tggggaagta gcacccccca ttccatgacc atgacaaaat gagggactat atggatgttc 134821 tttgccaagt gtgaaggtca atataaacat taattagaac tattcctctg tgaattattt 134881 gcacccttaa aattattgct cctagaagcc ctatagcttc tagggctgca attctttctg 134941 ttttttttac agttcctgcc acttcctctt ccagcaacaa gaacttatcc ttgaccctga 135001 aagtggctaa tgccaactca ccttccacag gtctatccac acagttagga tcagggtcac 135061 tgctttgttg ggattctgaa agaataaaga caagccagac atcattatcc attcagatgt 135121 agtgagaagc cacaaactct taaatctcaa tgatgcagaa tcaaatccaa agagaccgtc 135181 ccagcagttc catgcaggag aaatgcgtct atatgttcaa caaaagacat ggcacagaga 135241 ttcacagctg cattattcac cacagccacc aactggaaac tactcaaatg cccatccaca 135301 ctcaaatgat gaataatcac agtagactca cacagcgacg agactgaaca gtctacaact 135361 acacacttag gtggatgaaa agcataacga tgagcaagag aaaccagaca taaaaaaaca 135421 catgctgtgt aattccttta acatgaagtt taaaacatag gcaaacttag atctgcgacc 135481 ttagaagcca ggagagaggc ttcccttgca ggagtaaggg ggcgggggac aggaggacat 135541 aaggggcttc tgaaacttgc agtgtttgtt ctgggcccga gagcatggac tgtacagtgt 135601 gtgaagtgcc atgagttgta catttatgtg cacttttctg tttgtatgtt ataattcact 135661 gagatcttct ggaaaattaa gaagataaaa ccaacctgtc ccttgttaat tctcaacaca 135721 ataggctttg tgggtaacac ggcccctttc atttcttctt tccctgattc tcccttttga 135781 atgtatctgt tcatcataat gtttcacctg cattcaccga atgggattac tcatagcccc 135841 actcccatga cccagaggga atataccaga ggatgctaac tccacttact gtagttctct 135901 gccaggacag gcaccaaacc acatttgcct gcagtgtaca catatcctcc atccaaactc 135961 atggcatcag cttctccttt ctgcaaagac agagcagatc tccagcacca cagtgaggct 136021 gcatcccgtc ctgcctgtct atatagctct ctgagagaat ggttttctgt caggtgacca 136081 gtgaaacagc agaaagagat ggactattca aactgagcag ccagaggaaa caccgtgtgc 136141 accactaatt ctctcccagc cctgcctact ttctgggctg tcaattcaac tggaaagacc 136201 aggcacaggt tgcactaatc ctctgtcctc tgagcaaaac cttttctgtg tccctggcac 136261 tttggggaca ccttcctgga gcagtctcac tgactgagga cacagatggg aacagctggc 136321 ctcatctaat ctgaactcat tagcactcca ctccaagcgc tacacagaag ttgtccaaca 136381 cataagctga agtcgtcata ttggcccacc accagaatga acaagtccag gctacaacac 136441 aggatcatgg actcatcagt agtatgaaac ttcctctttg acccagtaat atttttacaa 136501 ctatattaaa aatagagaag tggacaaaga tttctactca agaatgctca ccacagggtt 136561 attgataata gcaaagtaag ggacaaagag gaatgggggc atgactaaac tgagccatat 136621 tcacataaaa gatatcctgg aagcatgttt aaaaaatgtt ttcgtccgag tgctgtggct 136681 cacacccgta atcccagcac tttgggaggc cgaagcagga agattgcttg agcccaggag 136741 ttcgagacga gcctgggcaa caaagcgaga ccctgtcgct acaataataa taataataat 136801 tatgcaggtg tggtggcgta tgcctgtagc cccagctact tgggaagctg agatgggagg 136861 atcacttgag cccaagagtt ccaggctgca gtgagatgtg gtcgcaccac tgcactccag 136921 cctgggtgac agatcaagaa tctgtctctt aaaaaaaaaa aaattaatgc tttccaagag 136981 taaatattca tgtggaagaa tgcccattat acgctgttta gtgaaaaggg cttaaaaacg 137041 acatactgca acacttcatt attgttgcat gcatatctgc agatgtgcag agaaatactg 137101 gaatggagaa ttagccagac tttaaccatg tctgtccctc tgtgtgagat cacaggtggt 137161 ttggggggtt tgttgttgtt ttgttttaac ataatacctt tccatatttt ccaaattcct 137221 tataataatc ctgagttgtt cttataacca gaggagtggg aaacccacag taaactgctt 137281 tttgaaacta aaatgctttc tggccctgag cacacctctc caggcatccc tgcctcaccc WO 00/09525 PCT/US99/17712 EPI-109 1137 137341 aggcccccgt ggcctcttg actgttgact tcactttaag cagatgccca ggccctaggt 137401 cttccaccgg gcccaccgcc cgcccctgtg atggagctcc ctaccagcac cagggcgatg 137461 cagtcctctg tggtggaggc cgaggagcag gtcacgctgc cttcgctcaa gccactccac 137521 tggttacact tgcgcagctc ctgctcgccc accgcacacc acacgacccg cgcacgccgg 137581 gcagccactt cctcctcacc tgccagaggg aagaccgcag gtggctgggc aacctgagct 137641 ttgccaggtt gtccaacctc cccagagcca gggtcctgcc cagactctcc ctggaacagg 137701 agctacagta catgtgtgga catgtggacc cataccctct cctcctccac ttctcagctc 137761 caagcccctt cttcaggtcc acagagctcc ctgtgtttcc cacttctgtt cctttggaga 137821 agttccctgg cttctaatct atccattaat ctttagagtc aggaggcgcc tattgtctct 137881 gtctctgagg ataaacgctc catgacccag agaccagtga cagtcccaag agatggccta 137941 ggggaccttg agcccaaccc tgacttcccc taacgcctgc aatcaccacc aataactacg 138001 gtgcagcctc tgggttcccc cagactccca cccccagccc cccagtagag aaggagccat 138061 agctgagttc ccccaccatg gtgtccccaa ctaagttcaa ggtctgggcc tgggaagtgt 138121 gggtaaatcc aggcccccgg attcatccag gaggggtcct ggctatcttt gttcatgttc 138181 atgtttctca cttaatagga ggcaaactga tttttctgcc aggcctgggg agcctgacgt 138241 gcactgatca ggtggccaga ctattctttt agagacacct gacctaatcc acagaagaca 138301 ctcacacctg catcaaacct ccacgatgac cccacagtgt ctgggaaaag gagtgaccgc 138361 cacaaagtag ggccacctgc tgggaagtag aagaccacac caggcggacc tcaggaccct 138421 cctgggctca ctcacttttc ctcaagttct ggatggcagt gaagtagccg gagccaaggt 138481 acagcccaga atctatcctc gggggcaccc tcgaaaaccc aatggcagag tccttgaaca 138541 gcagatcttt ctgcccacta ggggagccaa agagctggaa tttcggtgac ttgtcctttc 138601 caaacttttc ctaattaaga aaaaatagaa ttatggtgtc aatggtaaat agggaggaaa 138661 caaaaaaatg atgttaaaaa agagtatctg gagctttggg atcattctaa ctgagagcag 138721 gagcctcggt tgagaccctc ctgcagaggg acttgtgcca tctcggagac ccaagctcag 138781 ctatggctca ttctttgaag agttgctgag gtccaagcac cttagggccc tgagaagatt 138841 gcatcgacca ccccctgctt ctgctcccat cataagacgc tgtcagcccg tgtgacagaa 138901 gagtttcatt gcttctgctg tccacagtac agcctgggca agcagcccaa tgcattagtg 138961 tgctatcctg cagcaaagct acaggacttc tggagtggca gaagtcaggg aagtaagaaa 139021 ccttgctccc tgccccccat atccaagcaa gtggggagga ccgtgggtga agatacctgt 139081 gcctggcgga gaagattcca gatggcatcc tccttgccat tcacacttcg tgccacaacg 139141 gcatgagaag ggacccgggc cagatggcag tctttgaact tgtccactgg cttccgagtg 139201 ttgtctgggc agagtaactc atactcgtcc ctttcagcct cgtctgacag gtcctctgca 139261 gggaaggtga ggtgggaggg agtctagata agccgactcc agcagtaacc tcgagctata 139321 gttccccttc tccctataga attttgagct tggggagata gctgacaaaa ctgagggtca 139381 gaaaggcagg ggtttgctcc agaacactca gaaaggtaaa ggtagtgccc caaaagcctc 139441 agggggcagc cgaggtgtga tcctcatcct aaatcactta ggccaccctg gggttcccgt 139501 gcagctgctg cctggcaggc cagagaggcc aaaccagacc cgtctgtttc tgcggcatct 139561 ctgcctggaa aagtcacttt gcagagacaa gctcaggggg ccaccaaggg ttgctccctt 139621 actcacatct ctgggaagaa taaaaatgac aaaaatgtta acaaggcagg gaataaggca 139681 ggaaggtgag acactttcca acactgagta tatcaaaaga aggggaagaa tggttttatg 139741 aatgagttca ggcaaatgtg gaatatcata tataagttgc ttcagaatgt gtaaagtgaa 139801 aaaaatcttg cccgagtcat tttatgagat tagtacaacc ttgatgtcaa aatcagaaaa 139861 agtataggag ggaagaatta aaagtttatt ttacttacga acataaatgc aaaatttgta 139921 aataacgtac taactaactc aatctcacag agtatttaaa aagctaatag attggaatga 139981 aggtttacca gtgtattcca ttaacaaaag aatggctgaa catcaaaaaa actaaagtaa 140041 tctgcattta atggcagaaa accatgagat cgtcttcatc ttaatagatg cagaacgatt 140101 gtttatgtgt tcaacatcta tttgtgtgtg gttttttttt cagcctcaga aaaatagtaa 140161 tagatagaat cggtaaagtt tttttgtttg ttttgagacg gagtctcact ctgttgccca 140221 gcctggaatg cagtggtgcg atctcagctc actgcatcct ccatctcctg gagtcaagag 140281 attctcttgc ctcagcctcc caagtagctg ggaccacaag cgcacgccac caggcccagc 140341 taatttttgt atttttaata gagatggggt ttcaccatgt tggccaggct ggtctcgaac 140401 tcctgacctc atgtgatcca cccgcctcag tctcccaaag tgctgggatt acaggggtga 140461 gacaccacgc ctggccataa gttattggct tgataaatgc cattaatcta cagcaaaaac 140521 cttactaaaa gaagaaaatg tagacattca ccgcaaaatc aggaacaagg caaggatgcc 140581 cactgttaca atgccagcac aattctagat atccagatca cacaatttac aaaagaaatg 140641 tgagatataa acactggaag gaaaaagaca cactcttatt taaaaagatg atatcgtcat 140701 ctacaaaaaa ccaatgaaac caacagaaac taataaaact actcagagga gtaacaagtt 140761 ataagagcaa cctacaaaaa tcagatgtta tcctcattaa caataaccaa atagaaacca 140821 atatggacta taagatgtta caatagcaac taaaaccatt aagtagctaa taattagcct 140881 cccacaaaga cacatcagac ccacaaagga aaaattttag ttctatcaaa gaaactaaaa 140941 agaggtgtga tcaaatgggg gagatttagc atcaccatgg actggacaac ttaatgttat 141001 aaatatgctg atttttcatg gaacaattta aattcagtac aattcgaatc aaaattaaag 141061 tatgattttt tccagaaatt caacaaaata attctgaagt tttagctgag tatatttgaa 141121 aaggaataat aaagtgagag gggagaggga gctctctctc attctctctc tcttcctctc 141181 actggctctc tctctttctc tccaccagat agtaagaccc attggtaagc cacagtaaca 141241 aaagcagaaa aaatgcaaat acaccaatga aataaaatag ctcagaaact ggtccacttg 141301 gatatataca aacttggtgt agaattggct tcacatatgg cagaaaaaat atactttttt 141361 tattgtaagg taaattgcct cactgtaaag gggataaaat gctaaagcca aatctatatc 141421 tgactttcta ggtagagcac atataaatag atgaggaagg ggatcttcaa atcttatttt 141481 aggaaataat tatgatttgg gtgtgaagaa gggcatcttt gaaatatctc aaaactacaa 141541 accaacaagg tgaggcttgt ggatttgacc ttatcaatat caaggatttt tgatcaacag 141601 agactaccgt tgtcagattt ttgactgaga agaggtttta ctaaagttta aaatcagcaa 141661 tagtttgata cctagataga aggaacttct gtccttgaat caaaatcatg cagaaacaag 141721 gtgtgaaact caatttaaaa agtagtcaaa tgtcacaaaa taagaaaggg aagcccaaac 141781 ggctagcaaa tatgttgaaa tgatcaaact caccagctgt cagagaaatg aaaattaaaa WO 00/09525 PCTUS99/17712 EPI-109 1138 141841 ataaaacgaa ctatctattg cattacaacc atcattcgga caaaaaatac gaaagtcaaa 141901 aatactcca actgaagttg tggggaaatt agaacacttg cagag:;tca ttccagacag 141961 cagcttggtg atcctgggtg catgtggggt ctgtctctgg tggcccggg tgcatgtgga 142021 ggtctgtttc tggtggcctc tgatgaatgc ggggtctgtc tctgaragtc ctaggtgaat 142081 gtgggtgttg tctctttctc tggtggtcct gggtggatgt ggggtz:gtc tctgatggtc 142141 ctgagtgaat gtgggtgtct gtcactttct ctagtggccc tgggtazaat atagtagccc 142201 tgtctctatt ggtcttgcat gaaatgtagt gagcttatgt ccactatcc tgggtgcagt 142261 gtgtttagcc tctacatact catcaactgc tttattataa gtccagagg gacgctgtcc 142321 agcaggtaag taaggaacac aggtgaaggt atcagtcgtg tggctacatg tggtagagga 142381 aaagagagca caacctctgt ccatcactat ggtgacagag aagtaaaagg tggatgtatt 142441 ccacggaaca ctcctcaact gttaggaccc ctgagctaga catgtazaca acaataccga 142501 taaacctcta aaacaaaatg ctgagcagaa aacccaagta gcagga,:tc taatgctcac 142561 taaaacctct atgaacccag aaaccggaaa cacaaaccag cacaatctgt tctgcatgag 142621 cacatgtgtc ttggaggact ggaggacgca ttgccaagca cctaggcatg ggtgtctatg 142681 aggggaagag aaaggcagta ggcacaggag gtttgaagaa aactgazcat ttaaaatatg 142741 aaagatcata aaatcagagc tgtgccctgt aggaatcttg aaaatautct gccatgaact 142801 taggaatcta attagctcaa aggtcagagt catgatcaag taagataaaa ggggtcagta 142861 cccacggctc attaccctgc tcttaccaaa cactgtgctc tctctgataa aagccacgtc 142921 tccagccccg tctctcagac acctgtgaaa agagaaacca tcaggggaa gcacaggcag 142981 ccctccccag cccctccctg tggaacagta gccctggcac tcagca:cta tgggtttcta 143041 ctccctgcag ggcagggctc tgaagctt (2) INFORMATION FOR SEQ ID NO:25: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 149412 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:25: 1 tctagagcca aggtcacgga agcccagagg gcatcttgtg gctcgggagt agcctctgc 61 tgtcttctca gctctgctga caatacttga gattttcaga tgtcaccaac caccaagaga 121 gcttgatatg actgtatata gtatagtcat aaagaacctg aacttgacca tatacttatg 181 tcatgtggaa aatttctcat agcttcagat agattatatc tggaggaag aatcctgcca 241 cctatgtatc tggcatagtg tgagtcctca taaatgctta ctggttrgaa gggcaacaaa 301 atagtgaaca gagtgaaaat ccccactaag atcctgggtc cagaaaaaga tgggaaacct 361 gtttagctca cccgtgagcc catagttaaa actctttaga caacaggttt tttccgttta 421 cagagaacaa taatattggg tggtgagcat ctgtgtgggg gttggggtgg gataggggat 481 acggggagag tggagaaaaa gggggcacag ggttaatgtg aagtccagga tccccctcta 541 catttaaagt tggtttaagt tggctttaat taatagcaac tcttaagata atcagaattt 601 tcttaacctt ttagccttac tgttgaaaag ccctgtgatc ttgtacaaat catttgcttc 661 ttggatagta atttctttta ctaaaatgtg ggcttttgac tagatgaatg taaatgttct 721 tctagctctg atatccttta ttctttatat tttctaacag attctgtgta gtgggatgag 781 cagagaacaa aaacaaaata atccagtgag aaaagcccgt aaataaactt tcagaccaga 841 gatctattct ctagcttatt ttaagctcaa cttaaaagga agaactattc tctgattctt 901 ttcgccttca atacacttaa tgatttaact ccaccctcct tcaaaaaaa cagcatttcc 961 tacttttata ctgtctatat gattgatttg cacagctcat ctggccagaa gagctgagac 1021 atccgttccc ctacaagaaa ctctccccgg taagtaacct ctcagctgct tggcctgtta 1081 gttagcttct gagatgagta aaagacttta caggaaaccc atagaaaaca tttggcaaac 1141 accaagtgct catacaatta tcttaaaata taatctttaa gataaggaaa gggtcacagt 1201 ttggaatgag tttcagacgg ttataacatc aaagatacaa aacatgattg tgagtgaaag 1261 actttaaagg gagcaatagt attttaataa ctaacaatcc ttacctcca aaagaaagat 1321 ttgcagagag atgagtctta gctgaaatct tgaaatctta tcttcgcta aggagaacta 1381 aaccctctcc agtgagatgc cttctgaata tgtgcccaca agaagtr-gtg tctaagtctg 1441 gttctctttt ttctttttcc tccagacaag agggaagcct aaaaatagtc aaaattaata 1501 ttaaattaca aacgccaaat aaaattttcc tctaatatat cagtttoatg gcacagttag 1561 tatataattc tttatggttc aaaattaaaa atgagctttt ctaggggctt ctctcagctg 1621 cctagtctaa ggtgcaggga gtttgagact cacagggttt aataaaagaa aattctcagc 1681 tagagcagct gaacttaaat agactaggca agacagctgg ttataagact aaactaccca 1741 gaatgcatga cattcatctg tggtggcaga cgaaacattt tttattatat tatttcttgg 1801 gtatgtatga caactcttaa ttgtggcaac tcaaactaca aacacaaact tcacagaaaa 1861 tgtgaggatt ttacaattgg ctgttgtcat ctatgacctt ccctggact tgggcacccg 1921,gccatttcac tctgactaca tcatgtcacc aaacatctga tggtctgcc ttttaattct 1981 ctttttgagg actgagaggg agggtagca ggtagttaag agtgcaagct tcccgcattc 2041 aaaatcggtt gcttactagc tgtgtggct c tgagcaagtt actcaccctc tctgtgcttc 2101 aaggtccttg tctgcaaaat gtgaaaaata tttcctgcct cataaattg ccctaaggat 2161 taaatgaatg aatgggtatg atgcttagaa cagtgattgg catccagtat gtgccctcga 2221 ggcctcttaa ttattactgg cttgctcata gtgcatgttc tttgtgagct aactctagcg 2281 tcaataaaaa tgttaagact gagttgcagc tgggcatggt ggctca,:gcc tgtaatccca 2341 gcattctagg aggctgaggc aggaggatcg cttgagccca ggagttcgag accagcctgg 2401 gcaacatagt gtgatcttgt atctataaaa ataaacaaaa ttagctggt gtggtggcgc 2461 ctgtagtccc cagccacttg gaggggtgag gtgagaggat tgcttgagcc cgggatgatc WO 00/09525 PCT/US99/17712 EPI-109 1139 2521 caggctgcag tgagccatga tcgtgccact gcactccagc ctgggcgaca gagtgagacc 2581 ctgtctcaca acaacaacag caacaaaaag gctgagctgc accatgcttg acccagtttc 2641 ttaaaattgt tgtcaaagct tcattcactc catggtgcta tagagcacaa gattttattt 2701 ggtgagatgg tgctttcatg aattccccca acagagccaa gctctccatc tagtggacag 2761 ggaagctagc agcaaacctt cccttcacta caaaacttca ttgcttggcc aaaaagagag 2821 ttaattcaat gtagacatct atgtaggcaa ttaaaaacct attgatgtat aaaacagttt 2881 gcattcatgg agggcaacta aatacattct aggactttat aaaagatcac tttttattta 2941 tgcacagggt ggaacaagat g 1 agaagagctg agacatccgt tcccctacaa gaaactctcc ccgggtggaa caagatggat 61 tatcaagtgt caagtccaat ctatgacatc aattattata catcggagcc ctgccaaaaa 121 atcaatgtga agcaaatcgc agcccgcctc ctgcctccgc tctactcact ggtgttcatc 181 tttggttttg tgggcaacat gctggtcatc ctcatcctga taaactgcaa aaggctgaag 241 agcatgactg acatctacct gctcaacctg gccatctctg acctgttttt ccttcttact 301 gtccccttct gggctcacta tgctgccgcc cagtgggact ttggaaatac aatgtgtcaa 361 ctcttgacag ggctctattt tataggcttc ttctctggaa tcttcttcat catcctcctg 421 acaatcgata ggtacctggc tgtcgtccat gctgtgtttg ctttaaaagc caggacggtc 481 acctttgggg tggtgacaag tgtgatcact tgggtggtgg ctgtgtttgc gtctctccca 541 ggaatcatct ttaccagatc tcaaaaagaa ggtcttcatt acacctgcag ctctcatttt 601 ccatacagtc agtatcaatt ctggaagaat ttccagacat taaagatagt catcttgggg 661 ctggtcctgc cgctgcttgt catggtcatc tgctactcgg gaatcctaaa aactctgctt 721 cggtgtcgaa atgagaagaa gaggcacagg gctgtgaggc ttatcttcac catcatgatt 781 gtttattttc tcttctgggc tccctacaac attgtccttc tcctgaacac cttccaggaa 841 ttctttggcc tgaataattg cagtagctct aacaggttgg accaagctat gcaggtgaca 901 gagactcttg ggatgacgca ctgctgcatc aaccccatca tctatgcctt tgtcggggag 961 aagttcagaa actacctctt agtcttcttc caaaagcaca ttgccaaacg cttctgcaaa 1021 tgctgttcta ttttccagca agaggctccc gagcgagcaa gctcagttta cacccgatcc 1081 actggggagc aggaaatatc tgtgggcttg tgacacggac tcaagtgggc tggtgaccca 1141 gtcagagttg tgcacatggc ttagttttca tacacagoct gggctggggg tggggtggga 1201 gaggtctttt ttaaaaggaa gttactgtta tagagggtct aagattcatc catttatttg 1261 gcatctgttt aaagtagatt agatctttta agcccatcaa ttatagaaag ccaaatcaaa 1321 atatgttgat gaaaaatagc aaccttttta tctccccttc acatgcatca agttattgac 1381 aaactctccc ttcactccga aagttcctta tgtatattta aaagaaagcc tcagagaatt 1441 gctgattctt gagtttagtg atctgaacag aaataccaaa attatttcag aaatgtacaa 1501 ctttttacct agtacaaggc aacatatagg ttgtaaatgt gtttaaaaca ggtctttgtc 1561 ttgctatggg gagaaaagac atgaatatga ttagtaaaga aatgacactt ttcatgtgtg 1621 atttcccctc caaggtatgg ttaataagtt tcactgactt agaaccaggc gagagacttg 1681 tggcctggga gagctgggga agcttcttaa atgagaagga atttgagttg gatcatctat 1741 tgctggcaaa gacagaagcc tcactgcaag cactgcatgg gcaagcttgg ctgtagaagg 1801 agacagagct ggttgggaag acatggggag gaaggacaag gctagatcat gaagaacctt 1861 gacggcattg ctccgtctaa gtcatgagct gagcagggag atcctggttg gtgttgcaga 1921 aggtttactc tgtggccaaa ggagggtcag gaaggatgag catttagggc aaggagacca 1981 ccaacagccc tcaggtcagg gtgaggatgg cctctgctaa gctcaaggcg tgaggatggg 2041 aaggagggag gtattcgtaa ggatgggaag gagggaggta ttcgtgcagc atatgaggat 2101 gcagagtcag cagaactggg gtggatttgg tttggaagtg agggtcagag aggagtcaga 2161 gagaatccct agtcttcaag cagattggag aaacccttga aaagacatca agcacagaag 2221 gaggaggagg aggtttaggt caagaagaag atggattggt gtaaaaggat gggtctggtt 2281 tgcagagctt gaacacagtc tcacccagac tccaggctgt ctttcactga atgcttctga 2341 cttcatagat ttccttccca tcccagctga aatactgagg ggtctccagg aggagactag 2401 atttatgaat acacgaggta tgaggtctag gaacatactt cagctcacac atgagatcta 2461 ggtgaggatt gattacctag tagtcatttc atgggttgtt gggaggattc tatgaggcaa 2521 ccacaggcag catttagcac atactacaca ttcaataagc atcaaactct tagttactca 2581 ttcagggata gcactgagca aagcattgag caaaggggtc ccatataggt gagggaagcc 2641 tgaaaaacta agatgctgcc tgcccagtgc acacaagtgt aggtatcatt ttctgcattt 2701 aaccgtcaat aggcaaaggg gggaagggac atattcattt ggaaataagc tgccttgagc 2761 cttaaaaccc acaaaagtac aatttaccag cctccgtatt tcagactgaa tgggggtggg 2821 gggggcgcct taggtactta ttccagatgc cttctccaga caaaccagaa gcaacagaaa 2881 aaatcgtctc tccctccctt tgaaatgaat atacccctta gtgtttgggt atattcattt 2941 caaagggaga gagagaggtt tttttctgtt ctttctcata tgattgtgca catacttgag 3001 actgttttga atttggggga tggctaaaac catcatagta caggtaaggt gagggaatag 3061 taagtggtga gaactactca gggaatgaag gtgtcagaat aataagaggt gctactgact 3121 ttctcagcct ctgaatatga acggtgagca ttgtggctgt cagcaggaag caacgaaggg 3181 aaatgtcttt ccttttgctc ttaagttgtg gagagtgcaa cagtagcata ggaccctacc 3241 ctctgggcca agtcaaagac attctgacat cttagtattt gcatattctt atgtatgtga 3301 aagttacaaa ttgcttgaaa gaaaatatgc atctaataaa aaacaccttc taaaataaaa 3361 aaaaaaaaaa aaaaaaaaaa aaa 1 aagcttcagt atgcaaattt tcaatgacat gtgcctgtgg attctgaaaa ttcacagatc 61 tgtctaccct tagctgagac tgaaggcatc tacttcccaa tgaccaaatc ctggtgctgt 121 ggcgacactg agcaggaact ccattagaat atcaatatca ctctgcagac attccatgat 181 gtaagctatg ttttctcttg ccgcaattac acttaattta ccaccagctg cttcaatgtc WO 00/09525 PCT/US99/17712 EPI-109 1140 241 atgggctatc zgaaaaatg aagctccttt cgtagtcaaa ctggatgcaa gacacagcaa 301 atgagaagtt actaaatrat tggagtcctc atagctactg cctgctttaa tgaacaaacc 361 aattcttgat acagggcata gttttccaaa ggagaaatca taaaaccatt tggaaatttg 421 atgatctcaa agtcctgatg atgtggagcc actcctatgg gggtagctgt ggctttaact 481 ttgggggcaa crttgaggga ataaagtctc aaaaagaggg aataaagtct caagattgtt 541 cgtgacccat agtaacttct ggcttaaagg accattcggc aagtttttaa atgtattttc 601 tataatttcc atgtagtct ttatattttc tatttcttat ttaaaacctc tattttagct 661 cgtttccttt gacactgctc tggcagggaa aggggtggca ctgcctcatt actgccaggt 721 aggggtagaa atccattatc cacttggtct ccattgatac ccaaagtggg gagaggctcc 781 tgttactgct agtgagggtg ggagtccccc cactaagttt ctgctaatac tgtcctggtg 841 gcttgctact attcccatga agcctccact gatactacat tacttttggg tggtggcaaa 901 tgtcctgcct ctccactagc cctcctgctc taaaacaacc cgagtaggga gtgggaagga 961 agctttgtta ctggtaggtg ggagctgaag tccagacttg ccacattgtc ccactgatgc 1021 tacagggagg aggaagcggg ccacattact gcctgatagg gatgaaagcc ccagctccct 1081 acctggcctt cgctgatacc agcctgctac aggagtgaag agagatttga aggcctcaat 1141 atagcctgtc gagggtggaa gtcttgctcc caatgggcct ttagcagcat gggtgggtgt 1201 ggggccatag ctgtctctgt actgcttggc tagagtggag tatttgaggt ccaaaagttt 1261 tctgtctttc tagccctttg gttagaaaga gcagactttt gttggaagta tttttttgtg 1321 tttacctgtt gtatttccag gttcctagct tctccagcac agtctgggat gtgtgagaca 1381 cagagaaaat ccagtgatgt tactaccgta tggtttcttg ggtcccaacg tctctagcta 1441 atctgctcca ccttttggag ttttcttatt tgttttagat cagggattta gtcatattta 1501 ataggagaaa tatggaaaaa tacttctact ctatcttcct ggaagttcct gtttattttt 1561 tatgtccttt tcctctggct agaccgtaag agacttacga aacaaacact tacacattct 1621 actaaactca atgtccaaag tttgtgaact tcttgaatat tgcttgttca tttccacccc 1681 cagtcactga ctgaatctcc ctgctgtctg tctacaatgc caatgagctt ctggttaact 1741 tcttctcatg catgcttagg caacaacttc ccagttttac tacacttgcc catccctagt 1801 tttgttgttg cttaatccct tggcctagtg ccaccatact cctccagcag agcaaccaat 1861 tcttacatta taggacaaca catatccact aaaaacagtt catgccacac caaccacatt 1921 tccctttgtc aacaaaatta cttgatagat aattccagga atgcctgatg aagctgattg 1981 acaacaagat atttggcaga ctctctgctg cctatacata ccttagcatg tggaactcaa 2041 gtaatgagag gtccatttaa ttggattgaa ttgggctgga taggattgga ttgaatcctg 2101 tgggatggct aggctaaatt agaaatgaag actagtttaa cagcagtatc caaggatagt 2161 tgactaatga gttaatttta ctctcaaaga cagtctttag tagtaagctg taatgcatta 2221 tatcaaacta ttttccagtc aatgatttat aagttacttg aataaggatg ctaaagatgt 2281 gccttattga aatggcaatt agcacaaagt tgggaatgaa atctaattag ttaaataaca 2341 gaatcacata aaaaaggact tgaataaatg tagcatccta ccatgttcct ggatagaaag 2401 actgctatcg taaagatatt cattctcctc aggttaaatt ataaactcaa tgcaattcaa 2461 caggatttta aaaaactaga caaagtgatt ccaagtttac gtggaaaata aaatgtgagg 2521 gaccaaacaa tatttgaaaa agaaagagaa taaaatctca tccttccaga taccacaatg 2581 tattataaag caatagtaat taacatgagg gcagaaatga gcaagcaagt gaacaaaata 2641 agacagatag tcacaggaaa ctcatatatt tataggtgct ttgcgtataa tgaagatggt 2701 ccttcaaatc agttgggaaa agatgggtta ttcaataaat ggtgttgggt aaaattggtt 2761 atacattggt gagaaataaa gtgaaactcc tactttgtat catatgcaaa aaatagattc 2821 cagacagatg aaatatttaa atgtaaaaaa taaaattcta aaactactag aaaaaaaaga 2881 agaatatttt tattcctttg aaatagaaaa ggtcttacta agcaaaacac agaagtaata 2941 aatgaataaa tgaagacaaa tatgataaaa ataagttaaa aatataagca atctttcttt 3001 gttttttttt cacctttcct agaaaaaaat atataggcaa cttgttaagc aaggtagatt 3061 acaagaaaat atttacaaca tttgacaggc cacagattat tatccagcct catctgataa 3121 gaaaacttca acataaagat atctgttttt tttcttataa ggttcctcaa agtgagccaa 3181 tcacttctta agctgaacaa aaaacaaaac agaagtgatc ttttccaata atgaaaacaa 3241 acattgacag agcagctgta ggatcctttc aggcaaatta tgaaaaggtg ccctttctca 3301 gaaaccacag ttaccattca gctttgtgac cagaggtttg actgtaccct agtccctact 3361 agcaacccaa ccacataacc aacttcaaag gtcctgaatg actgtgttgt acttaatggc 3421 agatgatcta tctcccattt ttgtcctaag gattttccaa gataatatat ttctgcattt 3481 gttttgcttt tacttcactc caaattgaaa tctatttgtg ggataagact aaagaaatgc 3541 ttataggaaa attgatagca ccaaattcct atcttaaaaa atgaaaaagg tttcaaatca 3601 atgacctcag cttttacttt aagaaaatag aaaaagcagg ataagctaaa gccaaagtaa 3661 acagaagaaa ggaaattata aagataagag cagaaatcaa tgaatagaaa acaaaagaaa 3721 aaaatcaaac caaacagctg attctttaag cagatctata aaattgataa aactctagcc 3781 agattgatca agtaaaaaag agagaagaca caaattacca gtattaagaa tgagagaggc 3841 aatatcacta cagatcctac agatataaaa agtataaggg catactttga ataattttat 3901 gactataaat taggcaactt agataaaaca aatttcttga aagacacaaa caaccaaagc 3961 tcacctaaaa tactcacaaa ttgaatagtc ttatagctat tacaaaattg aggccaggcg 4021 cagtggctca agcctttaat cccagcactt tgggagggct aggaaggcgg atcacgaggt 4081 caggagtttg agaccagcct gactaacatg gtgaaaccct gtctctacta aaagtacaaa 4141 aattagccag gcttggtggt gcgtgcctgt aatcccatct actcaggaga ctgaggcagg 4201 agaattgctt gaacctggga ggcaaagttg tggtgagccg agatcgcgcc actgcacttc 4261 agcctgggca acagaacaag actccgtctc aaaaaaaaaa aaaaaaaaaa aaattgaaat 4321 tatagttaaa agtcttccca caaagcaaac tctagaccca gatggcttca atggtaaatt 4381 ctactggaca atcaaacagg aaacagtaat aattctccac aatgtctttc ataaaattga 4441 tgcggaggag atactctcca actcattcta tgaaactagc attaccctga taccaaaatc 4501 atacagagac agtgtaggaa aacaacagat cagtatcctt catgaacata aatgaagtac 4561 aatgcagtct tatgcataaa tcagagcttc attgttctac agataaggta atgtaggatt 4621 gttggttgcc cctccaggtc tgttaaattc acctccttcc ccagagagca tccttcttaa 4681 ggacagggag cctcaatatg tcagtcctca cagcacctcc ctcagtcttc agcacttacc WO 00/09525 PCT/US99/17712 EPI-109 1141 4741 agctcatcac cacaaccgat accacattgg ataatttcat gaattacttt agagcaaatg 4801 caagagaaaa aatggatttt tatataggag aagaaggagg aaattcttgt ggatttggta 4861 cagaataggg ccaagggaaa attacagatg taaaaagaaa agtgtgtgaa atagtatcct 4921 tagtgctcac aaatacaatg atttcattgt ttttaaaaat aaaaaatgac aaatgtctaa 4981 tgcttggtgg taatgcttta ttgaatgtgt gttatacact ggttcctcat tcctgaagtt 5041 agaaataata ccttcctctt ttcatttggt tatgtttgct gaaacaaatc aaaggctgag 5101 attgaaacac atgctacttc aggtggatga ccttactact aagctcatca caacagcact 5161 tacagctgaa gaccccagag tcctacctaa cttttgtcac aacccagatt ttggccatgt 5221 agttctgggc cttaccatta aagcagacag aagtcagagg aatgactcct ttccacttga 5281 agtgagctgc aggcttctag gaaaggcaag atgcacattt ccctcctgtg gagcataaag 5341 cctttgtaat tcaggactta ggacccatat ggatttgaaa tattatgaca ttggagctgg 5401 agtggttggg gacaacacca gtagtgttat aggccatgga atgtcaaaag aacatggaac 5461 cctgttaaaa tcattaaaca tcaaaactct cccctcctct ggtgatatgg tttggctgtg 5521 tccccatcca aatctcatct tgaactccca tgtgttgtgg gaggcaccca gtgggaggta 5581 attgaatcat gggggcaggt ctttcccatg ctgttttcac gatactgaat aagtctcaca 5641 agatctgatg gttttataaa ggggagcttc cctgcacaag ctctcttctc ttgtctgcca 5701 ccatgtgaga catgcctttc accttccgcc atgattgtga ggcctcccca accatgtgga 5761 acttttaagt tcattaaacc tcttcctttt gtaaattgct cagtctcaaa tatgtcttta 5821 tcagcaacgt gaaaacagac tatctgattt tctgtgggat gtggattatg accatggaca 5881 gagcataact gggacagagc tggaaaaaat attaattagg tgcttaaaaa tatttgttag 5941 aactatcttc atgaatgaga atcaatcctg tttccatggt gattcaccag gcatcaattc 6001 caagcatcca tgaatcagaa aagtcctatc ttctcttagt tatcatccag gactccaagg 6061 aaccataatt agccaacctg ttcacatttc cttttcattc actagcctcg aagtttccag 6121 gggacaggga ctctgtccta ttcatttctg taaccttacc acctgaccca gaatagctgt 6181 tccctgaaga tttggtggat tataaatgtg gatgtcttat ttctttgaaa gtgtgagctt 6241 caggtactga tcacgttatt ccaattatca atttagtatc tttcttcacc attaaactgt 6301 gaaattcttg agggaagaac ctatgactga tttatctctg taaactcatg ccaccagtat 6361 tcaaaatcac acctagcaca tagtaaacac tcaatgtttg ttgaatgact gaaggaatgg 6421 atgaaaatga acctccttgc ttctgaccag tggatgagtt gcttggccgt gttcctacag 6481 cctagagctc atcccctaaa gcatctgaag ttacccatta gtgcaatggt tcttgaacgc 6541 tggtgttgat cagaatcatc tggatgccca ggttctctga aataagatag ggtctaggca 6601 tttgtatttt taccaaggag gtgtgatgga gtcagatgca agaaggctag ttgaagaaac 6661 cacatgagag tttagtgtag tgtattagaa gactggtttg gctctgtcgc tagtggctac 6721 atcatcttgc tcaagtcatg ccagtctcag gacctcattc agtctcttca gctgtaatat 6781 gggtgggttg caccacataa ccagaaagat cccttccagc tctacccact tacaacatgg 6841 tcaaatttgg tctgattttt taaatcgtag tacaatatat atgacataaa attcaccatt 6901 ttagccactt taaatgtaca attctgtagc attaactaca ttcacattgt tgtgcaacca 6961 tcactaccgt ctacttccag aactcttcat cttgcaaaac tgaacctctg ttgtcattag 7021 tcactaacta ttcctctccc cccctccttc taggccctgg caatcaccat tctactttct 7081 gtcgctatga atttgactac tctaggtaac ttatataagt ggaatcacag catttgccct 7141 attatgactg gtttagttga cttagcacaa cctcctaagg ctcaaccaca ttttagcatg 7201 tgtcagaatt ttctttgttt ttaaggctga ataatattct gttgtatctg taaataacat 7261 ctttattcat ttgtccatca acagactgtt gagttcctcc catcttttga ctattgtgaa 7321 aaatgctgct atgaacctga gtgtacagac atctggttga gtactgcttt caattcattg 7381 tttatatgga tcatatggta attttatgtt taattttttt ggaactgcta cattgttttc 7441 cacagtgtac atcattttac atttccatca gcaatgcaca aaggttccaa tttctccaca 7501 ttcttaccaa cattttttat tttctgtttc ttatttattt gtttatttat tctgagacag 7561 agtctcactc tgtcacctag gctggagtgc agcagggtga tctcagctca ctgcaacctc 7621 tgcctcccat gttcaagtga ttctcctccc tcagcctccc aagtaaatgg aattacaggt 7681 gcccaccacc acgcccaggt aatttttgca ttttttttag tagtgatgag gtttcaccat 7741 gttggtcagg ctggtcttga actcctgacc tcaagtgatc cacccgcctc agcctcccaa 7801 agtgctggga ttacaggtat gaaccactgc acccaggcca ttttttgctt tttagataat 7861 agtcatccta gtgggtatga agtggtattt cattgtggtt ttgatttata tttccctaat 7921 gatcagtgat attgagcatc tttcaagtgc ttattggcca ttttcttctt tggagaaatg 7981 tctatgcaag tcctttgctc attttttaat ccagttgctt tttgttattc tttttgattt 8041 gaaagtgttc tttatacctc ttgtatacta atcccttatc agatatgatt tataaatatt 8101 ttcttctttt ccatggattg ccctttttac tctgttgata gtgttctttg atacaaaata 8161 atttttaatt tgaatgaagc ccaattaatc tatttttgtt tcttttgttg cctgtgcttt 8221 tggtgtccta tccaagaaac tgttgccaaa tccaatgtca taaagctttt tcccatgctt 8281 ccttctaaga gttttgtagt tacagctctt gtatttaggt atttgactat tttgagttaa 8341 tttttgtaca tcgtataaaa taagaatcca atttttattt tattttactt tttgtatgtg 8401 gatatccaat ttccccacca ccattcattg aaaagactgt ccttttccta tcgaatggtc 8461 ttggcaccct tgtaaaacat aatttgacca tatatgtgag ggtttatttc tgggctctct 8521 attctattct attctattct attctattct attctattct attctattct attctattct 8581 attggtccct atgtctttct ttattctagt accaccattt tgctcatcat aactttgtag 8641 taagttttga agtcaggaat cgtaagacct ccagctttgt tcattttcaa ggttgttttg 8701 attattcaag gtcccttgat agtccatatg aatttcagga tggatttttc tatttctgca 8761 aaaaaaaaaa aaaaaaaaaa aaaaatcatt gaaattttta aacagattgc attaaatctg 8821 tagattgttt tgggtagtat tgacatttaa caacattaaa tcttccaatc aatgaactag 8881 gctattttta tttatttttt ctgtttcttt gagctacttt tgtagttttc agtgtataag 8941 tttttgctac ctggttaggt atacttctaa gtattttcta ctttttgatg ctattgcaca 9001 ttgaatcgtt ttcttaattt ggtggtagcg gggattgtgc attgttagta cataaaaatg 9061 caactcattt tttgtgtgtt gattttgtat cctgcagctt taacaaattc atgttagttc 9121 taacagactt attctatgaa tcattagggt tttctacata aaagatcatg tcacctacaa 9181 acagagataa ttttactcca ccccttcccg ttgcaatgcc ttttatgtct ttttcttgcc WO 00/09525 PCT/US99/17712 EPI-109 1142 9241 taattgttct ggctaagact tccactacca tgttgaataq aaatggtgaa agtagacatc 9301 cttgtcttgt tccaatctta gagccaaagc tttcagtctt tcacggcctg aaagactttg 9361 taatatgttc tcaaggttaa agaacttcag aagttttcta agcaagagac cattttatta 9421 acttagttgg cagcaattct gagagattag aatgaaaaga tagaggataa gaagtatctg 9481 gcaggtataa tatattgagt gtgctgaata tacttttagt tttgtatagg tgttaaaaaa 9541 tggcaaagga ggccgggcgt ggtggctcac gcctgtaatc ccagcacttt gggaggccga 9601 ggcgggcaga tcatgaggtc aggagatcga gaccatcctg gctaaaacag tgaaacccta 9661 tctctactaa aaatacaaaa aactcgctgg gcatggtggt ggacacctgt agtcccagct 9721 actcgggagg ctgaggcagg agaatggtgt gaacctggaa ggtggagctt gcagtgagcc 9781 gagatcacgc cactgcactc cagcctgggc gacagagaga gactccgtct caaaagaaaa 9841 aaaaaatggc aaaggaaaga atgaaaaata aagcaaggtc ccagaagagg ccaaaaatct 9901 taatcaaaat tgactgaaca ttacggaatg aaatggtttt tcctttactc caattaacga 9961 cttcacaaga agattccatc ctcgtttata agattaaccc aaaaccagca cttaaaacca 10021 gaagccttga aaggatggag tttggggacc cttctcatgt ctattcccag aagggggtct 10081 tcttctgggg tcctgtcccc taaagagcta ggcaaaaagt atgcttgcca catctgttga 10141 aagatagaaa gttggtctaa aaatacatga gagggaactg aaacatttca gagaaggcaa 10201 gactcagaag taagaaacca aaagaggaag gtaaaattct agttacaaag aaaagaggaa 10261 tggaaattaa attgtcttac agagaaaatc cagaactgcc ccctcttccc ttactactcc 10321 atcaaaaaag gggaaaaata gtcaatggga aagttttgag aaaaatagat ctctgcattc 10381 ttctggttga gaattcagac aacttgaact agagagctgg gtaatttctt gactaaaggt 10441 gtgttagatc tgaaagggtt tttcttaaaa ttgtctgtgt tcatccctcc catcttagag 10501 aggaacacag gataagagac ctctggagct cccccagggt caccgagcta ataggatcag 10561 agacaaagct acaaagtcat tttctgacat ctctccaggg ctcttttttt ctggaccccc 10621 catatcaaca tgatgtattt attacattgg attagcaact ctccttgagc tttcctcagt 10681 accaggttta catctcagtc tgtgggtctc agagaaagta cccaatcagc agcaacatta 10741 cctggaaact catcagaagt gcccctcctc agccccaccc cagatctatg caatcagaaa 10801 ctctggaaat gcaggccagt cctaacaagc ccaccaggga attctggtgc actaaggttt 10861 gagatccact gatcaaagaa ataatattcc ttttcttcat tataatagca tgaataataa 10921 ctaacatgta tttcacaatt tacaaaagag ctttatgctc ttgttaaatt tgagggtagt 10981 cttctcaaaa tctctgtgag gctagaaagt cagatattga aacacctgtt ttatgggttc 11041 aaagataggt tcaaaagaga gtaaatgatt gttggggtgg caggtccaga gagggcagga 11101 tcaaaactgc aattgagtct tctgccttat aaaccagcat agcttcccea aggcacgtca 11161 cttctcgata aaatggtgac aactagagtg tcctttcaga tcattcttag aagcatggag 11221 tgctaggtca attgtgtaat tgatgaggaa ataataatac taagaactcc catcttctac 11281 gtccttatat acaatcctgt caggtagaag ctgagtctca gagagaacaa gttgccctcc 11341 caggaccacc aggtaagctc ggcatagctg tgcttagaat gtaggctgtc tggcttctgg 11401 gcttgcctgc ccagggaggc tttgtgggtt ctacttggtc atccagatca cagaggggca 11461 gcactgactc ctacccagtg ctcttgactg tacatctaat actttctact aagaaaaccc 11521 cttctcttta gaccaatggt tttcaaatct tggtgtgcat tggaatcacc tggaaagctt 11581 gttaaaacac agattgtccc accccaagag tttctgattc tgtaggctgg ggtggggacc 11641 catgaaagtg catttctaat aaggtcccaa gtgatgctga tgccaccagt gtgtggacaa 11701 ccctttgagt ggtgaagctc tggacaccct aatttgcaag gctaatcagg catatgtggc 11761 aaatgaatac gaactgaaat tctgactcca atatcttcac tgatattcct aatccatagc 11821 atacacacag tcccattcgt ttccctttta gcttttaatc tacatttatc ctttcttcct 11881 ctgccactgc cttctctcca gttagctcaa accaggtaac acataaccgc ctcctaactc 11941 atccgcccag ttggtttctt tggctttaat ctagacttct tatctccacc agatttgcct 12001 taccaaagca ccaatttctt aaggcagggt tagaattaaa aatcttctgt tcctcctcat 12061 tgcctaaaac tcctaaactt atgattcaag gtcttccatg accttcatgg accagtctaa 12121 cgttttagcc tgtcctaagt gacatgcctc caccacatac ttcatgcttt ccactttctt 12181 tctccatgtc tttgttcatg catttccatt tcttctacct gcgatgtcct ccttcgccat 12241 ctctgtagat ttaaaaatcc tacagggctc atctcaaatg ccctttcctt catgaagcct 12301 ttcatgaaat ccccatcgag aggttttccc tcctctcagc tctccaaagc acagatgtct 12361 gcgtttgtgg ctattatctt acgttgtttt gtattaaaat ttctccagct ttacacattt 12421 gtcatcctct taaggacaaa catcttatta tggtcaatgt gaagctatag aggataattt 12481 aatgaaatat tccaagggct agtcattaca catgactgat ttatctctgt aaactcatcc 12541 acactcatcc acctgatttt gattggccaa gttaatgaat cagagaggaa aagatggtaa 12601 aaatataata aaaatctcct aggtagtctc acatcccaca gagccccagg taatgaaatg 12661 aggccctgag ataatacttt atgaacaata aaactccggg ttctattgac agtgaagcaa 12721 gacctgagag agaaggctaa attcccttgt gtctagctgc cacaatcttc tgagaataat 12781 ggcctttctt cccgtctgcc ttctgaatca taggcaaatt tttctctttg gtgatcccta 12841 atacagaaag gggaagtcaa ataaaatata tacaaggaga aggattctgg gagacagagt 12901 ttcttgattc ccttctgcat gctcctcctc aaaagccttt atgagcttac cttacattta 12961 aattctttta aacaaggcat tatgtggtct ggtcttttcc agctccacac accttcacac 13021 tacattcccc ccagctaatt ctgctctggg aacactgacc ttcttttagt tctttgaaca 13081 cattgatttc tggtcaagat gactcagtaa cttcaacctt tgttgtgccc ttggtgctgt 13141 gaagatatag atatatatta accactgcac accagaaatc agaaatagca caacagagaa 13201 taaagtcatt gagccatctt ctgagctcca aaagacaaat tttctccaaa aagacaaatt 13261 caggctctaa aacaatacct taaggaacca gaagtggaat agaaaattaa ggtggtaagc 13321 agggctaaac cacatgcctg ttgagcccag gtttggaaga agacaatggc aggtaggaat 13381 gtggtttctg atgggtaata ggtactgttt tcatttactt tctgttgctt ataacagaat 13441 atctgaaact gggtgcttta taaagaaaag gaatttatgt cttgcagtta gggaaactga 13501 gaagtcaaaa gttgagggct gcaattgaca agtgccttct tgctggtggg gatactctga 13561 agagtcttga ggtggtatcg ggcataccac tctcagtgag gggactgagc atactaggtc 13621 aggtctttct tcctcctttt ataaagctat cagtcccact cttatgataa cccattaatc 13681 cattaactga ttagccaatt aatccatgaa tggattaatt cattcatgag ggcagagcct WO 00/09525 PCT/US99/17712 EPI-109 1143 13741 tcctgaccca aacacctctt aaagactcca cctctcaata ctgccacatg ggggattaaa 13801 tttcagcatg agtttttgat gagacaaata ttccaatgat agcagttatt aaaagtacat 13861 gcttgagaga aggggattgg agtcagcctc agtgcttaaa ctcaaaagct aggatgaggc 13921 tctaacactc ctgaaagaag gagttgctgc tggctcctta ccagggctat atcttttaca 13981 gagcaggaga cctaaagagg caggaggacc cggacatcgt ttggaaacca agcactaaaa 14041 caggccatct gttatacccc caatatcctc tcaggacaag tgttttgaac cactcacaca 14101 aggactagtc tgggcaagtg ggctagatga agaaaccaca aaatagctaa gtggggagag 14161 aaagaccaaa aatactattt tattcaaaat gaaaatacaa tccaaaattc catgattcat 14221 gaagaaatca aatggtatgt gttaggtggt tcttgcattg ctatagagaa atacctgaga 14281 ttgggtaatt tataaagaaa agaagtttaa ttggctcata attctgcagg cttcacagga 14341 agcatggtgc tggcatctgc tcagcttctg gagaggcccc aagaagattt gctcaaggca 14401 gaaggttaag ggagagctgg cacatcacat ggtgagaaag gaagctagag agagagtgca 14461 gggtgaggtg ccacaagtta ccacagccag atctcttgag aactcactta ctttcatgag 14521 gacagcacca agccataagg tgtagggagc caaagtccca tgggacatga ccaactcagc 14581 attccactgg aggctatatg atcaaacagc aaactgttta tcacgaatgc aggatgtgag 14641 caaactcaca actggtcctg ccaacagaag gtttgttgga ggcaatcact ccctggtgcc 14701 tgaggtaatc tactgcaaca tctagagaat gcagtcttgc aagcctactc tggacagggc 14761 agctggcacc ttattccatc ccccttctca ctatcttttt ttgcctaata aatacagagg 14821 gctgtgtaaa gctcagggcc cttgtccact agaggcaagt tgccccctga ccccttcttc 14881 caaatatact cttttgtctc ttgtctttta ttctcacatt tgcccccttt gttcagttcc 14941 actaggtccg tgcgggttat atactggtgc cctgagcagc aacagaatca ggctctcaac 15001 aagtgtcatc cgaacatggg actttgagga catgaacgaa gaaggtctgc tggagcagag 15061 gaacagaaat tgacaaggtg aacagggacc ctgggacgag tctgccagca gcggatataa 15121 ggtcagttac ctaaagaggt actgatcagt gccctaaaga gatactggga gcagtgcttt 15181 aaagaagtac tgggaatggg aaattttctg aatcagggta acaaggggaa gaatttgtct 15241 attaaagaaa aacattatgt gcagttgctt aaagttgtat tggaacagtc tggagcttag 15301 gttaatttgc agacactaac tatcacatgc gtccgtgtga agagagtcca ccaacaggct 15361 ttgtgtgggc aataaagctt tttaatcacc ttggtgcagg tgggctgagt ccaaaaaagg 15421 agtcagcaaa gggagataga ggtggggcag ttttatagga tttgggtagg tagtggaaag 15481 ttacagttaa aagtggttat ctcttgtggg cagaggcagg ggtcacaagg tgctgggtgg 15541 ggaaatcatg agactctttt tctgggacag gagtgtcaca aggtcaattg atcagttggg 15601 gtggggcagg aacaaatcgc aatggtggaa tgtcatcact taaggcagga actgactatt 15661 tcacttcttt tgtggttctt cagttgtttc gggccatctg gatgtatagt gcagctcaca 15721 ggggatatga tggcttaggt tgggctcaga gacctgacat tcctatcttt ttatattaat 15781 aagaaaaaca aaacaaaata gtggttaagt gttggggcag caaaaatttt ttggggtggt 15841 atgtagagat aaggggcaat gtttctcagg gctgcttcaa gcacgatcac ggtggtgtgg 15901 gaatctagag tgggagagat taagctgaag aaaaattttg gggaaagggg tgatattctg 15961 gggttgttag aaggagcatt tgtcatatag aatgatgatg gcctggatgt ggttttgtat 16021 gaattgagaa actaaacgga agacacaagg tccaaataag agaaggagaa aaacaggcat 16081 taaaggatta agaattggga ggacacagga catccaatta gagagtgccc aagggggtcc 16141 agtgtaatta tttgcctgga caatgagttt tggggctcta ttaggttgtc atataccagg 16201 ccagattgat ttaggtaaaa acaacactct tcatttaaaa tatacagagt cctccttttt 16261 tagcagtgag taagttgaga cctattcctg tcttcttata ttaataagta aaataaagca 16321 aaatagaggt gaagtgttgg tgtcatgagg ggaacaggaa gcagttcggt cctatttgca 16381 aattgatttt gggggggtaa agaaaactag tgtacctttg cctgtccaat taataagtag 16441 acacatgtag atggaggagc cacagaggaa gaagagaact ttgtaaggca aaactggaaa 16501 tgtaaaggga aaagatgaga gggagcacca aaagaggtgt cttgcaccca gactcaggga 16561 tctagtgaga gcagcagctg ttagaggttg taatggggat taatggggct actgggtaga 16621 gggggaggtt caacttttat ggtgtatgag aaagcgcata gtgtctacaa gcaacctttc 16681 attgctattc ataggattgg gtataagtaa acaagaaggg ggggctagga ggagagtctg 16741 aagaacaagg ggaaggtagc caaggatgga gtgaaatgta gggcaaatgt cttaaaggaa 16801 atgagaggtt ctaagaggag ggctagtggc ttgtaaccca catggaagag gttacgaaag 16861 gatgatagaa tggaatgagc ctgtgaggct ggaaggagga attttccttg gtccaagaac 16921 catttgcctt gtgtgggaag agtttgatag gtggaagttt cagtgggagg gtaggcggga 16981 gtgactgatg agaaggagaa aaactggcca taagggacag aagttggaat gctagctgct 17041 cctttagcta ccttatcagc ataagctttg ccctgagtga tgggatctga tgccttttga 17101 tggcgcttgc agtgaatgac cctagcttcc ttggaagtag agcagcttta agaagagttt 17161 ttatgaagaa ggcattaata atggaggacc ctcgtatagt gaggaaacct ctttcaggcc 17221 atataacaga atggaggtgg agaatatgga aggcatattt agagtcagta taaatactga 17281 cacacaatcc ttttgcaaga gtgagggctc gagttaaggc aatgagttcg gcttgctgag 17341 agggagtgga gtggggcaga gtggtagcct caatgataga tgtgaaagat actatagcgt 17401 agcctgcctt tgctggtgag tggtgattag gcctagtgga actgccatca ataaaccaag 17461 tgtgatcaga gtgaggaaca ggaaagaagg aaatatggga aaatggagtg aatgctaggt 17521 ggatcagaga gatacagtca tggggatcag gtgtggtatc aggaataatg tgggaggcca 17581 gattgaagtc caggccagga acaatggtaa ttgtgggaga ctcaacaaag agtgagttca 17641 actgaaggag ccgggggagg gggagagcgg cagaaagtat atgcatcagg tgtgaggaag 17701 aaaatacatt ttgaaagtta tgagaactgt agagagtgag ttgatcatag tttgtgattt 17761 tgagggcctt taaaagtatt aaagcagtgg cagctgccac acacagacat gagagccagc 17821 ctaaaacagt aaggtcaatc tgtttagaca gaaaggctgc agggcactgt ccaagctctt 17881 gtgtaaggat tctgaccgca cagccttgta ctttggctgt gtgtaatgaa aagggttggg 17941 atgagttagg gagagctagt gtgggagtag cttctagggc tgtttttaag gaacataaag 18001 aggagtgggg aaaggattta ggatctatgg ggtcagctag gtttcctttt gtgagtttat 18061 gtaatggttt agtcaggatg gcaaaaccag gtatccaaag gtgaaagtac ccaaccatgt 18121 ctaggaagga aaggatttgt tgctttgtag aagggattgg ggtttgggag attagccgga 18181 cacagatcag gagggagagc acttgtattt ttatgaagaa ttatgccgat aggtaacgga WO 00/09525 PCTIUS99/17712 EPI-109 1144 18241 tgaggaaaa atttgggctz tagaggggga tacacgarat tcctzaga atagatatzg 18301 gaggagcagg agggrgtc-t :tgggaaga ttcataggag gggctataaa gtagaaggcc 18361 atcaaaatat tgaataaggt gacaagcaga tggacagaaa agtaaatzat gagaaagggc 18421 ttgactgaag taatggaggc zgtccctgaa gccttgtggc agtacagccc aggtaagttg 18481 ctgagactga tgggtgtcaa ggtcagtcca agtgtaagtg aagagaggct ggggtgaaga 18541 gtgcaaagga atagtaaaga aagcatcttc aagatccaga acagaataat gggttgtgga 18601 gggaggtatt gaggatagga gagtatatgg gtttggcacc acagagtgga taggcaagac 18661 aatttggttg ataagctgaa aatcctggac aggctttagt cccttcaaag cctgttgtgg 18721 gatgggatac tggcattgaq caggataagg gtaattaggt tttaatggga tggtagggtt 18781 gcgtgatcgg tcaccaagga gggagtagag gtatcccata cttgtgggtt aagataggga 18841 gtcaggaggg gaggttgtaa aggaggcttt gaactgggga aaagggtggc aatgaggtgt 18901 ggctgtagcc caggaatagt cagggaagca gataatttag ttaaaatgtc tcaatttaat 18961 aagggagctg ggcaggtggg aataactaaa aaggagtgca taaaagaatg ttgtccaagt 19021 tggcaccaga gttggggagt tttaagaggt ttagcagcct gaccatcaat aacCacaaca 19081 gttatggagg caagggaaac aggcccttga aaggaaagta atatggagtg ggtagcctcc 19141 atattgatta agaaagggac agacttaccc tccactgtaa gagttaccca aagtgtctgt 19201 gatgatccag gaggcttctg aggtgatcag gcagtgtcag tcttcagctg ctaagctgag 19261 aagatctggg aaggagtcaa tcagagagcc ctgggccaga gttccagggg ctctgggagt 19321 ggctgacggg caagttggac agtccgattt ccaatgcggt cccacacaga tgggatacag 19381 tttaggagga atcctgggct gtaggcattc cttggcccag tggccagatt tctagcactt 19441 gaagcaagat cctggaggaa tgcctgacca cagtggttta ggtgttttga agttcttgtg 19501 tgctggagat gtggctgagg tttttctcac agcagaggca agtaattgca actcagaaat 19561 acattgccac ttggctgtct cttctctatt attgtacacc ttgaaggtga ggttaattaa 19621 gtcctgttgt ggggtttgag ggccataatc taatttttga agctttttta atgttgggag 19681 tggattgggt aataaaatgc atattgagag taagacagcc ttctggcccc tctgaaccta 19741 gggcagtaaa atgtctaaga gttgttgcca aagggaccat ggactgggct gcgttttcat 19801 atttgatgaa aaaaaaagag cctaaatgct aactaatttg ggagaggtca gataaagtaa 19861 aaggaacatt aatcttgact atgccttcag ctcttgccac ctctctaaga ggaaattgtt 19921 gggcaagtgg aggagtgcta gtcgtggaat gaaaccataa gctggactgg gtgtgaggag 19981 gggaggtgat agaaggatta cagcgtaggg gagtagaggt tgaggaagaa ttgggacctg 20041 gctcagcctg gtgaggagtg gcctggtgag gagcagcctg gggaggagga gagaggttag 20101 atgggttcgt agaaaagaag gattcaaagg actcggagct tggtgaggag actgaaggaa 20161 cagacaggag agaaagaaga aagatttggg acaagtcgca ttgggagcag agactaggaa 20221 gggagtgatg tgtaaagaat gcctggacat caggcacctc agaccatttg cccattttat 20281 gacaaaaatt atctaagtct tgtagggtgg agaaatcaaa agtgccattt tctggccatt 20341 tggaacaatt atcgagtttg tattggggcc aaatggtgtt gcagaagaaa ataagatgct 20401 taggttttaq gtcaggtgag agttgaagag gttttaggtt ttttagaaca caggctaagg 20461 cagaagaagg aggaatggag ggtggaaggc tgcccataat aaaaaggtaa gtttagagaa 20521 aagagaggat agagacacag agagaggggg tggtggtact catcagccag gggaggtggt 20581 acttgccacc aaggtgatgg atcaaggcag tcatccccac ggtgatcaga cacctctgaa 20641 atgtgggtga ataatcaggc aggtgtccct gcagtgatta gacaccaagg ggagactgtc 20701 ttcccgagtc cgtgaccggt gctggagttt tgagttcaca gataaaacac atctcctctg 20761 tctctaccag aaagggaaag gaactgaaat taaggaaggg agagattgaa gggtggagag 20821 atagcaagag agttggaaaa gagaataaaa agaggccact tactcaattt aaaattggtg 20881 agatgttcct tgggctgatc tgaggaccca aggttgtagg tggatctcct cacggaatga 20941 gggtgaggac aggggactgg tctccagaag gagttcccga gtcctagatc ttcagcacca 21001 aatgtcatgt gcatccatat gaagagagtc caccaacagg Ctttgtgtta tcaataaagc 21061 tttttaatca ccttggtgca ggtgggctga gtctgaaaaa ggagtcagca aagagagata 21121 ggggtgggtc agttttataa gatttgggta ggtagtggaa agttacagtt agaggtggtt 21181 atctcttgag ggcagaggtg ggggtcacaa ggtgctgggt ggggaaatcc tgagacttat 21241 catccaggga aggagtgtca caaggtcgat tgatcagttg gggtggggca ggaacaaatc 21301 gcatggtgga atgtcatcag ttaaggcagg aactcactat ttcacttctt ttgtggttct 21361 tcagtttctt caggccatct ggatgtacac gtgaaggtta cggggatata tgatggctta 21421 gcttgggctc agaggcctga cactaacctc ctgcagaagc cacaaaaggt tattacacat 21481 aaaccatggt ttccacaggc aggcactctt gatgtggaaa attgggatag agcaggatta 21541 aaacaagctc atcaaaaagg tcttaaagtt gattcttcag ttttctccac ttggagttta 21601 gttcatactg tacttctgcc attatctcct tattattctg cggaacagca ggctgaatct 21661 aaaaattgga aagaatttgt tgtcctactc acagctccaa ttgaatataa aaaacaggag 21721 agggaggata aaaattggcc tataccgcct cctccagatg cagaaacatc tgtaccatct 21781 ccttcagtgg cagaaataga gatcccagta caaagaattt tatgctctgc tgtcatagct 21841 ggagagccct taggaccttg tgcttttcct atttctgtaa ggcctgatcc aaataatcca 21901 cagcagttta ttcatgaaca ctctccacta gaatttaagt tgttgaagga attaaaaact 21961 agtgtggtca ataatggagt acaaagccaa tggttcctgg aggaaggaat gctagacata 22021 gaactttggg agcaagtggg gagaaatctt aaacaacacc aggcacaaag gcatcaggtc 22081 ccagtaaaat cttttatgtt aggggctttg agtagagcag ccctggttgt tacacacaaa 22141 agagcctaaa aagggaaagg aggaggaaat gtcacctgcc ttatcacctc cccttccctc 22201 agtgccaata tcactgggcc aaaataacaa agaggaaatg gaggtcttac ctaagcttcc 22261 tcctccaata gataggaaga aggacagagg atacgctaca gctatcagtc cctgtcttaa 22321 gcaggcagca ttagaaggag agctcttagc cgggtgcagt ggctcatgcc tataatCcca 22381 gcactttggg aggccgaggc aggcagatca tgaggtcagg agatccagac catcctagct 22441 aacatggtga aaccccgtct ccactaaaaa tacaaaaaat tagccaggca tgttggtggg 22501 cacctgtagc cccagctact tgggaggctg aggcaggaga atggcataaa cccaggaggt 22561 ggagcttgga gctgtcagtg acctgagatt gcaccactgc actacagcct gggcaacaga 22621 gcaagactcc atctaaaaaa agaagaagaa ggagagctct taaccgctc agtaatgcaa 22681 aatcggcaag gcaatcaggt gtatgtttat aaaaagataa gaaaaaggca ttagaagcca WO 00/09525 PCT/US99/17712 EPI-109 1145 22741 aaaccaczg zccaaacaaa caazgggcag gagaaaazgc tcaaaggcag aaaagctcac 22801 agcgacaaag ccaacaaggt ctacccagga cggcagcatc cc:ggcaa aggagcaagg 22861 gagcagcaca gacacaggca aagcctaaac aagtacaatg tggccacctc ccaggacctg 22921 caccactacc ctctggctct gtgggcagcc cattgcaaaa tttcatgtgt tacatctcag 22981 gctatgattc tctgctaaga tgtaagtaaa atgtaagaat ttgaaaagca tcttttctaa 23041 taatggccac tattgtcatc tctctcctat ccctgatgta gctttccaaa ttcaatttaa 23101 gtaaaacagt aacctttgaa gggaaagaga ttacagaggg cccatgaatt agttgaagag 23161 taatcaaaag ctaggcatgt aaaaccacac attacgcttt aaagaagaaa tttaaaccta 23221 attaaacgat atttgttaaa ttagaaggta aaaatgttgt gccctgttgg gaacaggccc 23281 ccaaatctgg ccataaactg gccccaaaac aggccataaa caaaatctct gcagcaccat 23341 gacatgtttg tgatggccat gatgcccacc ttgaaggttg ttggtttact ggaatgaggg 23401 caaggaacac ctggcccacc cagggcagaa aattccttaa aggcattccc aaaccactaa 23461 tgatagcatg agcaatctgt gccttaagga catgttcctg ctgcagacag ctagccagag 23521 cccatccctt tgttttggcc catccctttg tttcccataa ggaatgcttt cagttaatct 23581 atgatctata gaaacgatgc ttatcaCtgg cttgCtgtCa ataaatatgg gagtaaaact 23641 ctgttcaggg ctttcagctc agaaagccat aagccccctg atttcccact tcccaccctt 23701 tatttctatg tgtgtgtctt gaattcctct agcgcctctg ggttatggtc tccacaacca 23761 cgctggtctt ggcaqtgccc ttctcagaaa gtgaaaaaga gttgtatgta agtgtagtga 23821 aaacataagc atgaatcact gtcttaaccc actgattaga tagtctttga tttgtacttg 23881 ctaaaagagt cctaaattga gttcctcagc tagtgagtca ctgttttcaa gactgtttgc 23941 cagattgaag tccataaact tggtcagccc gaaaactcaa ttacaagatc taagctattc 24001 tgcctgtggc tttaagcaca tggttaaagt atattattta agtctctcct tctagatatg 24061 ctttcagatt ttctttttaa acttcttgtt acttatttca gctttccata ttgataatta 24121 atgcagtcaa ttgctcagtt atgactgtga tatcatcagg attcctttaa gtaaaaggca 24181 attcaaagcg gtattgcact cccccatacc taatgcttta acactgttta ctgatgggtc 24241 tggtaaacat ggaaaagctg cagtctagta gagaccacat aattcaatca ctcgatctga 24301 gttcactagc actcagagag ctaaggttac tctgtttatt tattaaagaa tttttacaac 24361 cttaagctca cccggactt tccagcctta tgtggcaaat gtagccatca atttatgggg 24421 tcaagactta cttacagcat gggatatgag gcttacaaat gagactttga taacccagga 24481 ttttaaatgt tgaagaacac gggatatcag agtgaaaaag gtttagggaa aattctgaca 24541 agggaaaatt ctaacctgat atcaataact ggaaagacag gttaaaccct gcaaggggat 24601 acattgacat tttttcttcc tcacttgctc ttttctgctg tctgaatatg ggcatgaggg 24661 caagagtcat tttagaccac caagtgacct tgaggataga agccttatac tagaggtggt 24721 gggaaagaaa aaacagaagg actcataaag aaaaaaataa taaacctcag tattaagatg 24781 gaaaaattcc cccaattggt ctataggttg aacttcatct ctattaaatt tcagctatgt 24841 ttttgcagaa tttgatatgc tgatcataaa atttatatga aaatgcaaga gacacagaat 24901 agtcaaaact ttgaaaagaa gaaagttgga ggacttacac ttgttgattt taaggctttt 24961 tacaaagcta taataatcaa gacaatgtgt tactgacata atgatagaca tattgatcaa 25021 tatagacaat ggatgaatgg agtagaattg acagtctaga aataaaacct tatatatatg 25081 gtcaatttat ttctttatgt attctgtcat ccagaataca taaagaacac cttcaactca 25141 ataacaacaa taccaacaag ggtgccaaga ccaatcaatg gaggaaataa tagtcttttc 25201 aagaaatttt gctgagacaa ctaagtattt atatgcaaaa taatgagttt gaatggctac 25261 catatacaaa aattaactca aatggactat attaggtcag tgcaacagta attgcagttt 25321 accaccatta cttgtttttt ttttttggtt tttttttttg agacagagtc ttgctctgtc 25381 acccagacca gagtgcagtg gcatgatctc agctcactgc aagctccact tcctgagttc 25441 acgccattct ccttcctcag cctcctgagt agctgggact acaggcatct gggtaatttt 25501 tttgtatttt tagcggagat ggagtttcac catgttagcc aggatggtct caatctcttg 25561 acctcgtgat ctgcccacct cagccccca aagtgctggg attacaggca tgagccacca 25621 cgcctggcct accattactt ttaatggcaa aaatgcagtt acttttgcac caccctaata 25681 gaactaaatg taagagctaa aactacaaaa ctgttagaag aaagcatagg agcaaatctt 25741 aatgacatga gagttggcaa ttgtttttta gatatgacac caaaagcatc aaggacaaaa 25801 gaaaaaaatg gataaattgg acttcctcca aattaagaga acttttgtcc tgcaagcaat 25861 actattaaga aagtgaaaag acaagtcaca aaatgggaga acatttttgc acataatata 25921 tttaataata ggctgacatc cagaatacat aaatacctac aactcaatac caaaaagaca 25981 gcccaattta aaaatgggcc aaggatatga ataaacattt ctctaaagaa gatacaaaaa 26041 tggtcaatat gcacatgaaa agatgctcaa tatcaatatc tattaggaaa atacaaatta 26101 aaacacaaaa tataaaacac aagatatcaa tttacactca ccaggatggc tgttatcaaa 26161 aagacagata acaagtattg gcaaggattt ggggaaattg taaccttcat acattgctgg 26221 taggaatata aaatttgcag caggtttgga aaacagttta gcagtttctc aaaaagcctg 26281 ggcatggtgg ctcatgccta caatcccagt gctttaggga gctgaggtga gaggattgct 26341 tgagcccagg agttggagac cagcctgagt aacacagtga gacctctttt ctaccaaaaa 26401 gaagagagtt aaacataggg taccatataa gccagcaatc catctcctag atatgtaccc 26461 aagaaagttg aaaacatata ctgacacaaa aacttacata tgaatcttca tattagcctt 26521 ataataatag ccaaaaagta gaaacaaccc aaatacccat caactaatta aaatatggtg 26581 tatctataca tattatttgg ccataaaagg aagtactgat acatgtcata acacaaatga 26641 accttggaag cactatgatc tctgtattag tcagctcttg tattgctata aagaactacc 26701 tgagactggg taacttataa agaaaaaggc ttaattgagt cacagttcca caggctgcac 26761 agggatcatg gcccaggaga cctcaggaaa cacagttatg atggaaggaa gagagtgaag 26821 gaggaggtgc tacatacttt taaaccacca gatcttgtga gaagtcactc actatcatga 26881 gaacagcaag ggagaagtcc acccccatga tccagtcagc cccagccagg ccccaactcc 26941 aatattgggg attacaattc cacatgagat ttgggtgggg acactaatcc aaacaatatc 27001 attctgcccc agcccctccc aaatcctgtg tccttctcac attggaagat acaatcatcc 27061 cttctcaaca gtttcatttc agtattaact caaaaatcca aagtctcatc tgagacaaga 27121 caagtccctt ccacctatga gcctataaga tcaaaaagaa gttagttac tccaagaac 27181 aatggaggta caggcattgg gcaaatatat ccattccaaa agggaaaaat tagccaaaac WO 00/09525 PCT/US99/17712 EPI-109 1146 27241 aaaggggcca caggccccac gcaagtccaa aatcaagcag ggaaatcatt aaatcttaaa 27301 gcttcaaaat gatatccttt gactccatgt ctcacatcca ggccacacca atgcaaggag 27361 tgtgctccca aggccttggg cagctctacc ctgttgctct acagggtata gccccCatgg 27421 ctgctttcac aggctggcat tgagtgcctc cagcttttcc aggtacacag tgcaagctgt 27481 tagtggatct accattctag ggtctggaag attgtggccc tcttctcata gctccagtag 27541 acagtgcccc agtgggqaat ctgtatgggg gctgcaaccc cacatttctc ctctgcactg 27601 cccaatagag gttctccatg agggctccat tcctgtagca tacttctacc tggacatcca 27661 ggtgttttca tacatcctct aaaatctagg taggggctcc caagccttaa ctcttgccct 27721 ctgcacatcc gcaggcttaa taccacatgg aaaccaccaa tgcttatggc ttgcacccta 27781 tgaaacagta gtctgagaca tatctgggcc cttttggcca tggctgggat gcagggaaca 27841 gtgtcctgaa gtggcacagg gcagcggggc catgggcctg gcccatgaaa ccttctttcc 27901 tcctaggcct ccagacctgt gatgggaggg tctgcctcga cggtctctag aatgtgtttg 27961 aggcatattc ctcattgtct tggctattaa tatttggctc ctctttactt atgcaaattt 28021 ctacagcctg attaattcct ttccaaaaaa atggggtttt cttttctact acatggtcag 28081 gtcacaaatt ttccaaactt ttacgcttcc ctttgaaatg taagttccag ttgcaggtca 28141 tttctttgat cacaaatata agcatatatt tgtagaatca gecaggccac atcttgaatg 28201 ttttgctgct tagaaactgc ttccaccaga taccctaaat cattgctatc aggttcaaaa 28261 ttctacatat ctctagggca agggcacaat gcctccaaga cctttgctaa tgcataagaa 28321 aattgacctt tgctccagtt cccaataagt tccccatctt catctgaggt ctccttagcc 28381 tggacttcat tgtccatatc agtatcagca ttttcatcac aataatttaa ctagtctcta 28441 agaagttcca aactttccct tatcttccta tcttcttctg agccctccaa actgctccaa 28501 cctctgccca ttacccgggt tccaaagctg cttccacatt ttcggtatct ttatagcaat 28561 gctccattcc tgataccaat tttctgtatt agtctcttct cgcactcctg taaagaacta 28621 cctgagactg ggtaatttat aaagaaaaga ggtttaattg actcacagtt ccacaagctg 28681 tataggaagc atggttcaga aggccacagg aaacttacaa tcatggagga aggcgaagag 28741 aaagaaggca cqtcttacgt ggctggagta ggaggaagag agtgaagggg gaggtgttac 28801 acacttttaa acaaccagat cttgtgagaa ctcactcact atcatgagaa cagcaaggga 28861 gaggtctgcc tccatgatcc aatcacctcc taccaggctc ctcctccaac attggggatt 28921 atgatttgac atgagatttg ggtagggaca caactccaaa ccatatcaat cccatttata 28981 tgaaatgtcc acaatagata aatctataga gacataaaat agattggtgc ttgcctagtg 29041 ctggacgtga caggagggtg tgagtaaaag aggcaatgga gtgataggta cagggtttct 29101 ttttggggtg atgaaaatat tataaaatta gattgtggtt atagttgtat aactcttgaa 29161 tatcctaaaa atatattgaa ttttccattt ccattttaaa tgggtgaatc ttatggtatg 29221 tgaattatat ctcaataaaa ctgcaaaaaa tgcacaattt gcaattgcaa aaatatggaa 29281 ccagtccaaa tgcccatcaa tgagtggata aaggaactgt ggtatatata tatatatata 29341 tatatatata tatatatata tatatatata tatatataca cacacacaca caccatggaa 29401 tactactcag ccataaaagg gaataaaaca atggcattct cagcaacctg gatggaattg 29461 gagaccatta ttctaagtga aataactcag taatggaaaa ccgaatatca tacattctca 29521 ctcataagtg ggagctaagc tatgaggatg caaaggcata agaatgatat aatggacttt 29581 gggaactcag ggaaagggtg agagaggggt gaggaataaa aggctaccca ttgggtacag 29641 tgtacactgt tcaagtgatg gctgcaccaa aatctcagaa atcaccacta aagaacttat 29701 ttacataacc aaataccacc tgtttctcaa aaacctattg aaattaatta atttttaaaa 29761 actgctgaaa tcaatagtga aaggatggac tattcaataa tgacacagtt aattgaatat 29821 catattttaa aaattagatc cttacctcac actataacat aacaataaat tccaggtgaa 29881 ttatagacca aatatgaaaa gcaaaatttt aatattttag aagacaattt ttatgacctt 29941 aagttagaaa atgattttta aaaacaggat gcaaaaacac taatcataaa gagatatttt 30001 aggccaagca tggtggctca cacctgtaat cctagtactt tgggaagctg aggcaggtgg 30061 atcacttgag gtcaggagtt caagacaagc ctggccaata gggtgaaaca tgtctctact 30121 aaaaatacaa aaattagctg gaaatcgctc gaacccagga ggcagaggtt gcagtgagct 30181 gagattgtgc cactgcactc cagcctgggt gacagagaga gactccacct caaaaaaata 30241 aataaataaa aataaagaga gattttaata aggtgcatta aaataaaaaa ctatccatca 30301 aagacaccat gaataaagtt aaaataggcc acaatgagaa tatatttgcc atgaattttt 30361 tctttttttt tgagatggag tcttgctctg tcacccaggc tggagtgcag tggtgcaatc 30421 tcggcttact gcaaacttca cctcccaggt tcaagcaatt ctcctgcctc agcctcctga 30481 gtagctggga ttacaggtgt gtgccaccat gcctggctaa tttttgtatt ttttgtagac 30541 acggggtttc accatgttgg tcaggctgag ctcaaacccc tgacctcgtg atccaccttc 30601 ctcagcctcc caaagtgctg ggattacagg catgagccac cgtgcctggc ctaccatgaa 30661 tattttttta aaggtagcat ccagaattaa taatcttctc caacaaattt cattagtagt 30721 cagggaactg caaattaaaa tcaaagtaaa atactacttt ccactcatta gactaaaatc 30781 cattcaagtc tgataatacc tagtactgag ttggagtaat agaaactgct aatgggacag 30841 ttagttggtc atcactttgg agagaaatta gtcagtatct agtaaaagtt agtgatacac 30901 cttccatttt catctgttct gtgctgctac caaagaatac ctgagactag gtaatttata 30961 aataatagaa atgtatttct aatggttcta gaggctgaga agtccaagat tgaagggcca 31021 gcctctgcag agagccttct tgctgtgtca tgccatggca gaagggcaaa gagagggcaa 31081 gagagagcaa aagcaaattc acagcatcaa tcccttttat aatcagcatt actctattaa 31141 tgagggcaag accctcatgg cctaatcacc tctaaaaggt cacacctctt aatactattg 31201 caatggtaat taagtttcta atacatactt tttgggagac attttcaaac tatagcacct 31261 accctatagc ccaacatttc tactcctagg agtatgccct agagaaattc tgcataaata 31321 tctaaagaga ggccattgtt gcattgttag gtactggaaa attggaatca attactatgt 31381 ctaccagcag cagaagatgg ctttttaaaa gttttggttt attcatgaaa tggaatattg 31441 cataaagtat gctccatctc accagatgaa aacatttttc actaggacta tttcaaaagt 31501 agtcttatca ctgggcttct ctattatgca taaaaatttt aagtgaacat gttctttgac 31561 ctaggactcc tacttttagg aatttgccca aaagggacaa ttatactact gggaaaatc 31621 tttgaacat aaagtaagtt gtaaatggta caagcagtat gtcttatttt tatttaaagc 31681 acattaacaa tattacacat atagtaaaaa ataaataaat aaaacatgtg aataataaac WO 00/09525 PCT/US99/17712 EPI-109 1147 31741 acccaattta gaacaaatgtgacagtgga gagggaaaga gagagaaaga aggagaaatg 31801 gggagtggga gcgggtacac aaagaaattt -agttgcagc tccaaatttt tactttttac 31861 acaatgaagc gaatatagca aaataaqatt tgttaaagtt gggcagcagg tacacagata 31921 ttctatcatt atcctttgaa tatttctgta gatttaagtt gtccattaaa aaaataaaat 31981 acacacataa tttttaaac tagttttttc catttcctgg ccttcgcatg cactgttaac 32041 tttacctgga attctttatg cagtaattaa gagcaaaggt gtagagcaag actgcttgag 32101 cttggatccc agcactgagt tgatttaggg agaataactt aatcttttaa tcccaagaga 32161 aaatatgata taatagtttt gagctcataa agttttcata agcattaaat gtgacctata 32221 tatgtaaagc aatctaacag tgcctatagt atttataagt gtctgcatta ccaaattcat 32281 cattatcatg gcatgtcata tcaccatcca ctacattacc atcactgtca ccatcatcat 32341 catcaccacc accatcatta ttaactccct ttgtctagtc aattcatatt tgttcttcgt 32401 attttagata cctgttaaaa tattttttca aagatgtcta ctctgattct tcagtacaaa 32461 tttgatttaa taagatccca tcatttatc caaatactta taaaaatttg tagttctata 32521 tttaatgtgt tttgtttgtt taacatctct ctcctacatt gtgttaagtt ttttaaagag 32581 aaggtaaggg ttaaagagag acacagagag agaaagagag acagagagag agagagagcg 32641 gttctacagc aatacaggta tattagaaaa acctgCaaag gtggggacca gcttaatgcc 32701 agagcccccc actgcttata ggctggggta cttataggtc tgggggtact tataggcctg 32761 ggtgggtggg gtctgagcag tatggcttgc tgcccaagaa gatgttgata agacgttccc 32821 atgatgaggc agtttggtcc ttgcttccat agagtgtgat gcttcttgca ctttttccca 32881 gcagaatgtg gtagggatgt tccttcaggt gggcctttgc ctggcagggt atgataagga 32941 tgttcctgtg ccttggaatc aggtagttag acaggatgtt tctcacagcc tgaaccccca 33001 tggaatgttt cactttgacc agggtctgcg aaatagcagg gggcttacaa aatggtgtag 33061 tttggactaa caccttggaa cacaaaagtt tcttggggcc aaggctggcg tattagtctg 33121 ttttcatgct gctagtaaaa acatacctga gactgggtaa tttataaaga gaaaagaggt 33181 ttaatggact cacaattcca catggctgga ggcctcacaa tcatgaggga ggcaaaggag 33241 gagcaaaggc acgtcttaca tggtggtagg caagagaacg tgtgcagggg aactgccctt 33301 tataaaacca tcagatctzz tgatacttat tcactatcaa aagaacagca cgggaaaaat 33361 ctgcctccat gattcaatta cctcccacca gattcctccc atgacatgtg gtaattatgg 33421 gaactacaat tcaagatgaa atttgggtgg ggacacagtc aaaccatatc agctgggtat 33481 gttttattca cctttttata cccattgtca tgtcttctgg acaaacaatg gatgtaaaat 33541 ggtatagact cctgagtact catttgttga atgacaaatc tatgaaccat ttgaccagta 33601 tgcagcagcc attaaaatta tgtttatgaa taatttacag catggaaaaa tttggggttg 33661 ctagtagaaa aacaaaaagg tacaaaagga tatatataat aagcctacaa tgccatataa 33721 acaatactaa cagcaaaaac aaacctataa attgggggaa gatggggcag atagaagtaa 33781 cctaaaatac taacatgttg ttttggggtc atgaaattat aaatgattat gcacccctta 33841 atttttactt tctatgtttg atttttctat ggtaaatgca tttttattga ggtggaattc 33901 acataacatg aaatgaaaaa tttagtggca tttattatat tcacaatatt gtacaaccac 33961 tagctctact tccaaaacat tttcatcact ccaaaataaa accttgtacc cattaagcag 34021 ttactcccca ttatttcctc tcttagctcc tagcaaccac caacctgctt tctgtctcta 34081 gggatttatt tattctggat attccataaa aatggaggca caatatgtac cttttatgtc 34141 tggcttcttt caccaagcat gtttttgagg ctaatccaca ttgcagcatg tatcagtact 34201 tcatttcttt ttatgaataa ctgtatacag accacaattt gttatccatt ttttggttta 34261 tggacatttg ggttgtttcc atctctcaac tattgtgaat agtgctgcta tgtatatttg 34321 tgtacaagaa tttggttacc tattttcaat tcttttatgt atatatctaa gatgaaattg 34381 cagggttata tgctaatcct atgtttagca ttttttttta ggaaccatta aactgttttc 34441 caaatctgat gccccatttt atattcctac tagcaatgta agcaagttcc aatttctcca 34501 tatcctcaac aacacttatt attttctatt tttgttatag ccattctaat gagtgtaaag 34561 tgatatatca ttgtggtttt ctcgcattt tccttatgaa cattgatgtt gagtaccttt 34621 tcatgtactt tttggtcatt tatatatcat ctttggagaa atgcctcttc gtgtatgttt 34681 tgcccatttt aaaactagat tgtctttgtt gttgacatgc atgcattctt taaatattct 34741 gcatactagg cccttatcag atatatgatt tgcaaatgtt ttttctcatt ttactggctg 34801 tcttttcact ttattgataa tgtcctttga tgcccaaaag ttgtttattt tgatgaagca 34861 tatttatcaa tttatttctt ttattgctca tgcttttgat gtcacctcta agaatttata 34921 accaaatcag aggtaatgaa ggtttacccc tctattttct tctaagagtt ttatagtttt 34981 gactcattta cttaggtcgc tgattcattt ttagttaatt tttgcatatg atgtgaggaa 35041 gaggtccaac tttactcatt tgcatgtgga tattcagctg tgccagcacc atttgtgaag 35101 agtctatcat ctcctcattt aataatagta ttgacacctt tgttgaaagt caattgataa 35161 taaatgtatg agtttatttc tggaatctaa attctattcc attgatctac atgtctatcc 35221 ttgtatcagt atcacactat cttgattact gtagatttgt agtaagtttt gaaactagaa 35281 agtgtgagta ctgcaatatt cttctttttc ttttttaaag attgtcaggg cctcttgcaa 35341 tttaataggg atatgaggat tgacttttct attctacaaa attaaaattt tgttagagat 35401 tgcattgaca ctgtaggtag ctttcagtaa cattgccatc tcaacaattt taagtattct 35461 aatacatgaa tatgagcttt ctttctcttt atttaggtct tctttaattt ctttcagcag 35521 tgttttgtag ttttggggta caagtctttc acctttaaat tttggtgaaa tttattccta 35581 ggtattgcat ttttttatgc tattgtaaat aaaattattt tctcaatttc ctgttggatg 35641 ttcattgcag gtgtatagaa actcaactga ttctttgtgt tgatcttatg ctgagaccag 35701 ctcagttggg gagaccctaa cctagaagca ctagaggaat taaagacaca aacacagaaa 35761 tatagaggtg taaagtggga aatcaggcgt ctcacagcct tcagagctga gagcttcaaa 35821 cagagattta cccacatatt tattaacagc aagccagtca ttagcattgt ttctatagat 35881 attagattaa ctaaaagtat cccttatggg aaacgaaggg aagggctgaa ataaagggat 35941 gggttgggct agttatctgc agcaggagca tgtccttaag tcatagatca ctcatgctat 36001 tgtttgtggt ttaagaatgc ctttaagcgg ttttctgccc tgtgtgggac aggtgttcct 36061 tgccctcatt ccggtaagcc cacaaccttc cagcgtgggc attatggcca tcatgaacat 36121 gtcacggtgc tgcagcggtz tttatggcca gttttggggc cagtttatgg ccagattttg 36181 gggggcctgt tcccaacaat cttatacctt gcaattttgt tgaatttgct tgttaacttt WO 00/09525 PCT/US99/17712 EPI-109 1148 36241 gatagttutt ttaaggata tttgggattt tctacatatc atatcatcta tgaataaaaa 36301 tagttttgct tttctttc tcatttggat g=ctttatt tccttttctt gcctaatttc 36361 cctggctaga acttccauta tgatgttgaa taaccatggt gaaatgggca ttcttgtctt 36421 tttcctgatg ttagagagaa atttttcagt crttaaccat tgagtataat gttagctgtg 36481 ggttttttac aaatatcttt tatcatgttg aggaagttcc ttcctactcc tacttcttgg 36541 agtgtttttg atataaaggg tatctaattt gtcaaatgct ttttCtgtgt cagttgagat 36601 tatcatgtga gattttttt ccttcattct attagtgttg atgttacatt ggttgatttt 36661 ttatgttgta ctacatttgc attctttata taaatttcac ttggtcatgg tgtataaccc 36721 ttttaatatg ccattggatt tagtttgcta gtattttgtt tagagttttt gcatctatat 36781 tcataagcaa tatcagtcca caggtttttt gtggtttatt tgtctggctt tgctataatg 36841 gtaatgctgt cttcttagaa tgaatgaggg agtgttttct cctctttcat tttttaaacg 36901 tttgagaagg agtgatatta atttttcttt aaacgtttgg tagaacttac cagtgaagcc 36961 gtctggttct taacattttt ctgtgttggg aggtttctga ttaccaattt gatctcttta 37021 atttttacag atcttttcag attttctatt tcttcttgag taacttttta gcaatttatg 37081 tattttagaa atttgttcat ttaatctagg ttatttaatt tattggtgtg cattttttca 37141 tagtattatc ttataatctt ttaatttttg taaagttgat aatgtcccca ccttacctga 37201 tcttagttat ttgtgtcttc tctgtattct ttttgtcttc ttcttctgtc ttagcatagc 37261 taaaggtttg tcaactttgt tgatctttta aagagtcaac ttttgctttc agcatgcatt 37321 actttttaaa tagaaatata tacacctaag ttgcattaca aaggagttgt cctccacaca 37381 cttattcttt cccaccatca gaggtttatg gtccccgcaa aagtcaccat cagttgggct 37441 caactccaat cagtcatggt aggtcagggt ccatctcatt gtctccatca ctcatgccca 37501 cccagggtaa gtctaatcat gttcaccaat cagaacctct gccacatcag ctctgtgggt 37561 ttcctctcat gccatctgta ccaacaatga gcacagtctg ggtttcctga tgttttctat 37621 agcatggtgc ccctccctgg gacacctcag aagccacaat gatattcatt aaacttcttc 37681 ctgcaagtac tccctctatt gctccttcta ctcaccaagc ttagtgtcag ggaatatgct 37741 ggtggggagt atgaatctta gcttctcact cccagactcg gctcccaacc tgctgttgcc 37801 aagtcttggg gacatotata aatgccttct aaatacctgt cttggcctat ccccagccac 37861 agattcctcc ctagagcagg ctacctctga ggcatctata ctgagatctt aatcacagag 37921 acatttaaaa catctaggct acaaaagaat tcctactata gggttcaaat gaatttcttt 37981 ccgtcacttg agacagcttt ttagcaagta catgtattaa agattctgat ttcccctttt 38041 ttctcctaca gtttgtttgg cctaaaggta tgacatctaa tctgctgcat ttacactcta 38101 agtcaaaatt accattttgt tcttttaatt tctatttcta atcatacatt cttgtctact 38161 cctggttcat ctggagacaa agttgaactt agaagatgga ggagaaattc ttatctgccc 38221 tctgctagtt gacacttcct ttccaagaat catttgcagt tgctgggctt tcttgctgtg 38281 actctatgcc ctgttgtgtt actttttcat ttgtgacaaa aacagtggta atagtttgct 38341 tcatttttat tatgaagact tgaccaggat aggtaggaac ataattactg ctttttctgt 38401 gggcatcata ttggtccaga tcatgtttaa ccagaattga agatgtaaaa tcctagaact 38461 cactaatcta ttttagtagg tcacaggaag catgcaaacc ataaaaaccg caatgaacca 38521 aaagcatctg tgttgacaag aggcaagaat ttctctattt tctaaaggca ctaactgaac 38581 aaatctattg cccattactt aggaaattgc taagggcatc gttaaagtac ttcaggctgt 38641 tgaaaaacct tttctgtctt cttgccccac caccaattct ctctagctat gctttctctc 38701 acatgttctt gccatccatg gagtggcaga gaggttctga gtacaactct aactttcagt 38761 ttcaatggcc taatccccaa ctcaactgct gaccttgagt gtaaaaataa acaagatctt 38821 aaacatctta gggccaqcat tctgggtctt cttttgttat ttggggagca taaactattc 38881 tcatatcatt ggcttgcaga aaaattgagc ttctcctctt ccttgcccca tgtcaccttg 38941 aggtgaccac agccctgcct tctatgtaat cctgcttggt cagcaggcac atcagagctc 39001 agtggcttgt gacatacttt ccttcaagcc tgctcgaagg gccatactca tcattgagac 39061 tgggaacctt agaaaccatg aacccagtgc caatgggtag atacagaatt ctcaaactca 39121 tgaaaaaaca tcctttttaa ctctctccgt gtgcataaag aattctaaga tgtactgatc 39181 aagattccca attttctaac tatctattaa tatatggacg aggtaagaag aaagttgcaa 39241 gaaaaaaatt tgtttgactt gacggttgtg tggttatttg ccacactccc ccagatccac 39301 tctgagtccc aggatgctga ttttaggggc tacattgcct agactgtcca ttattccctc 39361 ttcccatctg gttcagtcac tgggaagcac tggtaggagg tcagagtggg agaaggaggt 39421 taggatactt tctgcccctg ctgtcctact gctttgctga acttctagca gtggctgagc 39481 catcaacctg cagctctcaa ttccagctgt ctgtagcact caagtggtat tgtttattct 39541 tttgatcctt ctagctgtta aggaagaaaa aaataatttt ttcctcaatg ctcataagtt 39601 cttggaatgg acccctgtaa caaaagacag attaacacga gaaaagttta ttaacgtaca 39661 tattttatac gtacatagga gctatccagg gaatgaataa ttcttaaaaa ggtgactttg 39721 aattccagct catatagcat cttcaacaaa gttcagtaac attttagaga tatgacaaga 39781 caaagaaaat gaactttgag cctctaggga cagtgacttg taggaaggca aaaggaataa 39841 atggaggtaa aggctggtta gtaatacttg ttaatgaaga ttcctctggt gccatctcca 39901 ggtccacaag gatttaaatt tgtcttcagt ggtgaacctt tgttcaccct ggcagaaggt 39961 gtggaggggg gtgcagatcc gttttgtctt tgtaagtcta tatcctgctt ttagacaaat 40021 aaagggaggg aaaagagctt tccttcatct gcttcttaat tgccttcagc tcaacaatcc 40081 ttatgcaaaa gaggtacatt ttagggtgtc aaattctggt ctcccacaaa gcatagggat 40141 gacagaccac ctcaccatcc ctgttgcttc ttttaagcct gctcacccct ccaaaaatat 40201 tttcattcta tactgtctct tcaaaatctc agcggagggt gccctctgtt atcctgccct 40261 ctgtgtcagt ataagccaaa ggtttgaatc ctggctctgc aactatctac ctctgtgcct 40321 ctccttgttt atgaaattac agggctggag acaaagatca caatgtgaag acaaaattgg 40381 agagcggtcc taatcagcca gagcaaaatt tctggctctt gctcttcccc atcctgggtt 40441 gaatcatagg aacaggtggc aagatgccag ggtcaggaga ttccagaagt ggcagcaagc 40501 tcagtgttac caggtcaggg atgacctgtc ttattattga aatctcagag atatgctcca 40561 attccggccc agagacacat tgagagacaa ctggggaact tgctatgttc ctgaacaggc 40621 aatgagctgt cttccaagaa aaaacctgag acccttcaag tctcaggtct tacttagcac 40681 atataccagg tcttacacag gacacatggt tacaactgac tgaaatctgg gctgggtgta WO 00/09525 PCT/US99/17712 EPI-109 1149 40741 ggagctcaca cctgtaatcc cagcccttca ggaggctgag gcaggcaaat tgcctgagcc 40801 caggagtcg agaccagccc gggcaacatg acaaaacccc atctc7acaa aaaatagtca 40861 ggcatggtgg catgcacctg tagtctcagc tacttgggag gctgagatga gaggattgct 40921 tgaggttgag actgcagtga agcatgatca tgccaccgca ctccagccta ggcaacagag 40981 caagatcttq tcgcaaaaga aagcaaaaac acaacataac acaacaacaa caacaacaac 41041 aacaacagca aaaaagccaa cttcttgaaa tctggaaagg acacctggac tgccctgagc 41101 atttgattgt tgttggctct agcagtggat gcatccttca acctctggca ctctgcaggg 41161 ctcagactgt tctgttctgt ttgttacctg tggagtqcct gccagaccct gctctagctg 41221 ctttaggtcc atttaccctc atagaccccc agtcttgtta ttcatatttc atatttggga 41281 aatggaaact tagaaacttg ccaagtccac agcatgagat cctgcctccg gtgtctgctg 41341 gattccagaa agtgccaggg gccaacttag atgacaccat gttctctgca caatcttagg 41401 aatgctccta gtctgatgtc cccattgcaa aatttacatt atcttttaac aaaacgtctt 41461 tccaaggagg ggcatttaaa ataactgagg ttcttcttgc taaggacgtt cctgacacaa 41521 gagataattt agcatttcct tttcattaaa aagtttgaaa tcctgtaatt tgtgataatg 41581 tggatgaacc tagaggatgt taagtgaaat aagccacaca cagatagaca aataccacgt 41641 gatctcactc ttatgtggaa ttttttttta aataagttgc ttagccgggc atgatggcac 41701 acacctgtaa tcctagctac tcaggaggct gaggtgggag gatggcttga actcagaagg 41761 tggaggtagc agtgagctga gactgtgcca gtgcactccg gtctgggtga cagaatgaaa 41821 cccaatttaa aaaaaaaaaa aaagttgcta tcttagaaaa agacagtaga gcagtggtta 41881 ccagagactg gggaggaaag agaggaggtg agaatgggca gcagttgatc aacgggtaca 41941 aagttaccat gagataggag aaacaagtgc tggtgctctg ctccaagtag ggtgacggta 42001 gttaataatg aattctgtat atataaatag ctagaagaga gggttttcaa tatcattatt 42061 atttcaaaag aaatgataaa tgtttcagag gatggatatg taattaccct gatttgatca 42121 ttgcacaatg tatacatgta gcaaaacatc acattgtgtc ccataaatat atacaattat 42181 tatgtgaatt aaataaaaaa aaattttaaa gtcttatcta aatgaaattt ctaaccagat 42241 tctgaatcca tgataccact gaaaccagca cacatgatcg cagtaaaacc tcattatact 42301 tcctccacta tcaccaatac cctttattct ctggaacatg aaacattctg ttgtgctcat 42361 atcatgcaaa ttatcactag taggagagca gagagtggaa atgttccagg tataaagacc 42421 cacaagataa agaagctcag agtcgttaga aacaggagca gatgtacagg gtttgcctga 42481 ctcacactca aggttgcata agcaagattt caaaattaat cctattctgg agacctcaac 42541 ccaatgtaca atgttcctga ctggaaaaga agaactatat ttttctgatt ttttttttca 42601 aatctttacc attagttgcc ctgtatctcc gccttcactt tctgcaggaa actttatttc 42661 ctacttctgc atgccaagtt tctacctcta gatctgtttg gttcagttgc tgagaagcct 42721 gacataccag gactgcctga gacaagccac aagctggtga gttgtaggca ttttttccat 42781 tactttctga ttcataggct caacgcacct caaagctgga aatgccgggt ctgggtacac 42841 cctggggaac tgcaaagcct gcacacttgg gggaaatgat caagatgaga ggcaggggtg 42901 gggatggcat gtgcaccagg agatgttaga gaaaccctga ggaagagcag cgtgcagcag 42961 gtgatggggg agagtgggca gcaagcgagg ccaggacagc cactctgctc agtcaccagt 43021 ccacacaccc aggggctcac tctgcccctc tgagcaccca aggacgttaa agagctggaa 43081 ctgttagtct aaatatagga ccatccaagc tctgaaccaa aatgtgtccc ttgcctcaac 43141 tcaggagatc cacagaggca gaagtaagga atttattttc tgaaagatag atttctatca 43201 gttctgggtg acatgttctg acacttgaaa tgacacctag gacagcacat ttcaggcatc 43261 ttgctcattg ttcactgtag tagaagctac atgctagcca gttgtaaaaa tgaaattaag 43321 taatgtgtgc acagcattta acatagcatc tgagcttcag gagcactcaa ttaatgacca 43381 cagttgtgat tctttaggca gatgcatttt tttccaactt tgatcagagg tcttatttag 43441 cttctccaga tttcaagaat ctggctcagt gatatgaaat acaagacttg tgaaaagtgt 43501 caattgcaag agaaatggaa ggataaagta tacaggtggg tggaaaagaa attcacagtc 43561 actgccagaa aaaaaattct tgagaatcaa gtcctgatga tgttagggct tatagttctt 43621 attataaaga gttttatgta ctcattcagt gaacatttat tggtgcctcc tttagccagg 43681 tactatcata agagctgaaa ataaaagcat aatccagtcc ttgatcttga ggaacatgct 43741 gtgtgtagca gataacataa taagtgctta tctagatgca tgcagtgtta tgtgataaga 43801 gtaatatgac agaggataca gattaggctt cacagagaag ggggatttga gcaggaggta 43861 ttgaagggtg aatagaagct caccaatcat tttgggcaga ggggcaagga cctgcaaaac 43921 cactgaagca tgaaggaaat ggtgagttta gggaaaatga agagaagatg gctgtgactg 43981 aagcacagga tttgggattg gagaagggac tggaggtgag gctgagaaga ggcaaactca 44041 gaaaagatgt tgtgctgggc agtctggaca ttatctttga agcccaccac atataagtca 44101 tagggctact ggaggtttta agctaaaagt gactattcaa tttcaactta agagaagata 44161 ggttgagagg gaacatggct tgagatgagc catgagcaaa ggaaagacta caacaaagcc 44221 aggagtgagg agtgtgtgaa gcaagaaagt gacagttgaa agcagtgcag aggggatgaa 44281 tctgagaggc atctatgagg tggaactcaa atgacatgat aataatacag ggcatttctc 44341 tgtgtcagat gctgtcctaa gtccttactc cattgatctt cacagcaact cagcatagtt 44401 aatattttat gcataaagaa atcggcactt gaaggagtaa ttggccccag attacactgc 44461 ctataaggat tcaaatccag gtttgtttgg ctccaaaaac tggctcctaa ttttcagaag 44521 gagaagcgac ccagggcaat gcccaatttt gcttcttagg caatggagga atccacaatc 44581 ggaaggagtt ttcagcagtg ccccatttgg ggtgggttga atttgaggtc cctgcatgat 44641 acccactttg ctcacttcag tgcctaaaac tgagtatggt tcatagtagg tgttcaataa 44701 gtgttgatgc agtgaataca tgcatgggga gatatgcatc aggcaatggg aaattcaact 44761 ctaaggctta ggggaaagct ggagcttgaa gacagagctt tagaaaacag tagcatagaa 44821 gggagtagga accatgagtt tagacaatac aattcaggaa gaactttgta gcaaggataa 44881 agaggcaaaa aattaaagag gtgagagcta agtgtggtgC Ctggggaatc ttaaggtgtg 44941 ggcacgggga ggagatgcca gcaaagaaca tgaataaaaa gcggtagcac agcccctccc 45001 atctggaagc caaaaagaat tgtaaatgga ggaagttagc agaaggatca aatacttgaa 45061 gagggtggaa ttggaataaa accagggcat ttgaaaaatt gggttgtcac tgcaatctta 45121 acaagagaag ttttggcagg atgatggagg cagaaagctg agagaatcat cagctagaac 45181 gtttttgacc tcagagaaca gaaaatgcag ttcataatgg ctttaaaaca ggggcttgtt WO 00/09525 PCTIUS99/17712 EPI-109 1150 45241 tttctcccag caatttaaaa ggccaaggc agrgcatcag gaggtcaaga gaccgagacc 45301 atcctagcca acatggtgaa tccccatctc zactaaaaat acaaaaatta gcggggcatg 45361 gtggtgcacg cctatagtcc cacctaczca agaggctgag gcaggagaat cacttgaacc 45421 caggaggtgg aggttgcagt gagctgagat catggccact gcactatagc ctggagacac 45481 agcgagactc cgtctccaaa aaaaaaaaaa aagaaggcag aaggtgaata gttcaagggt 45541 gggtttagga ctcagtgata ataggattct gcctggcttc tcatggttct ctaggtcttc 45601 cattcatggc accatgccct cactaggcat gctgccagag caggaggggc aggtggaggg 45661 ttctcttgtg tctgtcttat cagggaagaa gagctttctc agaagccccc agcagactcc 45721 cttttcatat tatggtccag caatgagtca cagacctatg caccacctgc aaaggagcca 45781 gagaaaacaa acgcccagcg cttttagcct gaaaatgaga atctggtttg ctggggaaga 45841 taaagggtgt cggaaaatgg ctgttgggta aatcattgat gtctgccact aggaatgaaa 45901 ggcaaatcag gaactggcac acatgctttc agggagatgg ctgcaaggga gagggcaaag 45961 actgggaagt tgcttatgtg gtgccagact atttggaaga tcatggattg cggtgtttgt 46021 gttgtgtggt catcattttg ttctttgttt acagaacaga gaaagtggat tgaacaagga 46081 cgcatttccc cagtacatcc acaacatgct gtceacatct cgttctcggt ttatcagaaa 46141 taccaacgag agcggtgaag aagtcaccac cttttttgat tatgattacg gtgctccctg 46201 tcataaattt gacgtgaagc aaattggggc ccaactcctg cctccgctct actcgctggt 46261 gttcatcttt ggttttgtgg gcaacatgct ggtcgtcctc atcttaataa actgcaaaaa 46321 gctgaagtgc ttgactgaca tttacctgct caacctggcc atctctgatc tgctttttct 46381 tattactctc ccattgtggg ctcactctgc tgcaaatgag tgggtctttg ggaatgcaat 46441 gtgcaaatta ttcacagggc tgtatcacat cggttatttt ggcggaatct tcttcatcat 46501 cctcctgaca atcgatagat acctggctat tgtccatgct gtgtttgctt taaaagccag 46561 gacggtcacc tttggggtgg tgacaagtgt gatcacctgg ttggtggctg tgtttgcttc 46621 tgtcccagga atcatcttta ctaaatgcca gaaagaagat tctgtttatg tctgtggccc 46681 ttattttcca cgaggatgga ataatttcca cacaataatg aggaacattt tggggctggt 46741 cctgccgctg ctcatcatgg tcatctgcta ctcgggaatc ctgaaaaccc tgcttcggtg 46801 tcgaaacgag aagaagaggc atagggcagt gagagtcatc ttcaccatca tgattgttta 46861 ctttctcttc tggactccct ataacattgt cattctcctg aacaccttcc aggaattctt 46921 cggcctgagt aactgtgaaa gcaccagtca actggaccaa gccacgcagg tgacagagac 46981 tcttgggatg actcactgct gcatcaatcc catcatctat gccttcgttg gggagaagtt 47041 cagaaggtat ctctcggtgt tcttccgaaa gcacatcacc aagcgcttct gcaaacaatg 47101 tccagttttc tacagggaga cagtggatgg agtgacttca acaaacacgc cttccactgg 47161 ggagcaggaa gtctcggctg gtttataaaa cgaggagcag tttgattgtt gtttataaag 47221 ggagataaca atctgtatat aacaacaaac ttcaagggtt tgttgaacaa tagaaacctg 47281 taaagcaggt gcccaggaac ctcagggctg tgtgtactaa tacagactat gtcacccaat 47341 gcatatccaa catgtgctca gggaataatc cagaaaaact gtgggtagag actttgactc 47401 tccagaaagc tcatctcagc tcctgaaaaa tgcctcatta ccttgtgcta atcctctttt 47461 tctagtcttc ataatttctt cactcaatct ctgattctgt caatgtcttg aaatcaaggg 47521 ccagctggag gtgaagaaga gaatgtgaca ggcacagatg aatgggagtg agggatagtg 47581 gggtcagggc tgagaggaga aggagggaga catgagcatg gctgagcctg gacaaagaca 47641 aaggtgagca aagggctcac gcattcagcc aggagatgat actggtcctt agccccatct 47701 gccacgtgta tttaaccttg aagggttcac caggtcaggg agagtttggg aactgcaata 47761 acctgggagt tttggtggag tccgatgatt ctcttttgca taagtgcatg acatattttt 47821 gctttattac agtttatcta tggcacccat gcaccttaca tttgaaatct atgaaatatc 47881 atgctccatt gttcagatgc ttcttaggcc acatccccct gtctaaaaat tcagaaaatt 47941 tttgtttata aaagatgcat tatctatgat atgctaatat atgtatatgc aatatatata 48001 ggctcttgct tgatctctcc aggaggtagt gattatgaga agggggtgga gaatgatgag 48061 ttccttcacc aggagcaaag gacggggatc gtgtggaacc actgcagaac tatttccgga 48121 atcaactaag tggagagagc caggaaggct gcatcagaac ccagtaaagc ttcttgtctg 48181 gatctgagct ggtttgtttt gtgcttgctt ttccctgcct tgccactccc ctcactcttc 48241 tcttttcccc acagcctttt tcacatagct cttggctgta ggattgcccc actccaaaaa 48301 ccagtgtgtg gaggtccagg agtgagacca ggaaagaatg tgaaagtgac tacacaagga 48361 ctcctcgatg gtcgtggaaa aggaaagtca attggcagag cccctgaagc cagtcttcag 48421 gacaaagaag gagcctagag acagaaatga cagatctctg ctttggaaat cacacgtctg 48481 gcttcacaga tgtgtgattc acagtgtgaa tcttggtgtc tacgttacca ggcaggaagg 48541 ctgagaggag agagactcca gctgggttgg aaaacagtat tttccaaact accttccagt 48601 tcctcatttt tgaatacagg catagagttc agactttttt taaatagtaa aaataaaatt 48661 aaagctgaaa actgcaactt gtaaatgtgg taaagagtta gtttgagtta ctatcatgtc 48721 aaacgtgaaa atgctgtatt agtcacagag ataattctag ctttgagctt aagaattttg 48781 agcaggtggt atgtttggga gactgctgag tcaacccaat agttgttgat tggcaggagt 48841 tggaagtgtg tgatctgtgg gcacattagc ctatgtgcat gcagcatcta agtaatgatg 48901 tcgtttgaat cacagtatac gctccatcgc tgtcatctca gctggatctc cattctctca 48961 ggcttgctgc caaaagcctt ttgtgttttg ttttgtatca ttatgaagtc atgcgtttaa 49021 tcacattcga gtgtttcagt gcttcgcaga tgtccttgat gctcatattg ttccctattt 49081 tgccagtggg aactcctaaa tcaaattggc ttctaatcaa agcttttaaa ccctattggt 49141 aaagaatgga aggtggagaa gctccctgaa gtaagcaaag actttcctct tagtcgagcc 49201 aagttaagaa tgttcttatg ttgcccagtg tgtttctgat ctgatgcaag caagaaacac 49261 tgggcttcta gaaccaggca acttgggaac tagactccca agctggacta tggctctact 49321 ttcaggccac atggctaaag aaggtttcag aaagaagtgg ggacagagca gaactttcac 49381 cttcatatat ttgtatgatc ctaatgaatg cataaaatgt taagttgatg gtgatgaaat 49441 gtaaatactg tttttaacaa ctatgatttg gaaaataaat caatgctata actatgttga 49501 taaaagattt aaaaacaact ggctgttttt ttacactgtg gtgtggaaga ttgtgttgtg 49561 ttcacaactt ttcacttctt cccctgtgtg attacacaca cctgcccttg tggtgtgact 49621 tgcagtgcgc cctacaggcc acacaacccc agccctcca ccactggctc tgctgctgga 49681 atgtgagcag aagtgacatc tgcctcatcc aagcagagcc tcttgctcag ccacaggaag WO 00/09525 PCT/US99/17712 EPI-109 1151 49741 gcccattcca gatcacaccc qtcagcccgt gcgccctggt gaatgagaag acacagggag 49801 ctgcagccac auataacata agcaagaagt ctgtgtttgc gtgazaagc cactgagttt 49861 taggggttgt ttgttaagaa acacaaaaac cgattaagac atgtggtata tagtgacttc 49921 atatatagaa tctggaaaac tatccattta ttttcaatca tggaattcaa tatgacaagc 49981 atcccggagg gtctacctat gccagactgg gttggaaaca gaaagacaga tgttaatgcc 50041 agtgtccttt acacctccaa gtccaqggcc agctgtggag tgggaggggt agagaaggtc 50101 ctgtgcacag tcacagtgca ctgtgcagag caggaacaga ggcatctgtg aaaagtgctg 50161 agagcctgga ggacagagtg actaatgcaa tgacagtctt gcatcaragg aataacagcc 50221 acagcaggat tttattgctg ccaaagaaac tgccatttaa aaattgccag ccatccggga 50281 ggctgaggca ggagaatggc atgaatccag gaggcggagc ttacagtgag ccgagatcgg 50341 gccactgcac tccagcctga gcaacagagc cagactccat ctcaaaaaaa aaaaaaaatg 50401 ccagccatct ctctttctaa agtggaatcc tcaagtctcg tttattCtgg ggacatttga 50461 gtaggctgct cgagttaagc aggtggaagt tgatgatccc tcatcatcat tctgagggat 50521 gagtgtctga agactttttg qtaaggaagg gtcttggcat agcccacccc atgccacctc 50581 ccttqatctg tgatatcccc agcagctggg gaggttggag cattttgcaa agaggccccg 50641 aagcctccag aaagtaaacc ttcaagagcc catccttcct tcctcttttg tttttgctca 50701 ttatgaaaac ttccctgaca aattgaaaag gcttcaggtg agattagccc acaggaaaaa 50761 ccaccaaggg ccacccagag gggccacact gtgacagaag gagtatgggc tggtgagctg 50821 acctctggaa gacagtgcat gaattgagga gaagaqattg gttccaggca tgggaggaat 50881 gaggctggaa atttcttcag acattgccac ttcggcactc tgtgtgtgtg tgtgtgtgtg 50941 tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtaaacaga gtcctgtaat gcaaggtccg 51001 gccttggcag ccccagccta gagccacagt gagatgtgag ctgagggtta tgctgggaaa 51061 aacctctccc tcccagcacc tgaaaggctc tgcaggccca gcagctcagc aagcaagggt 51121 aagggcatgg actaacatct tatttcatac tatcccttat aacacatcct aatgtaatca 51181 gctcacaata tgaaattatt tcatttctct ccagtcattg tttcaatggg gccttagggt 51241 tgactgqatt ctggaggtcc ctgcctagag gagggggtgc attctgtccc tatgtcccct 51301 cccgctccat cctccacagc acgtgcctag tggtctacct tgtggggaat tcttgtacct 51361 ccctcttcta ggcatggact agcattgaga agtgggagag gagtgttagg aaaaagggca 51421 aatatagaca taccttgtct tattgtgctt tacagatatt gtttttgttg ttgttgttgt 51481 tgtttacaaa ttgaaggttt gtggcaaccc tgcctcgagc aagtctattg gtgctgtttt 51541 tccaacagca tgtgcttgtt ttacatctct gtgtcacatt ttggtaattc tcccaatatt 51601 tcaaactttg tcattatttc catatctgtt atggtaatct gtgatcagtg atctttgatg 51661 tcactattgt agttgttttg gggcaccatg aagtgcaccc atgtaagatg gcaaacaatc 51721 aataaatqtt gtgtgtgttc tgactgctcc atggactgcc tgttcctgag acacaataat 51781 gtatatataa caattatata tatatatatt tataacaatt atatatatat atattttttt 51841 tttttttttg aggcagagtc gcactctgat tgcccaggct ggagtgcaat gatgtgattt 51901 cagctcactg caacctctgc ctccccaggc tcaggtgatt ctcccacttc agcctcccaa 51961 gctgggacta caggtgtgca ccatcacacc cggctaattt tttttttgta tttttaggag 52021 agacagggtt ttgccatgtt gcccaggctg gccttaaact cctagactca aacaatccac 52081 ctgcctcagc ttcccaaagg gctgggatta caggcatgag ccactgtgcc cagcccaaga 52141 cacaataata ttgaaattaa gccaattaat aaccctacaa tggcctctaa gtgttcaagt 52201 gaagggaaaa gtcccacgtc tctcacttta aatcaaaatc tagaaatgat taagcttagt 52261 aaggaggaca tattgaaagt caaggccaaa agctcacctc tgcaccagtt agccaaattg 52321 cgacttcaca ggaaaagttc ttgaaggata tttaagctct actccaggga acatgcaaat 52381 gaagagaaaa caaagcagcc atattgctaa tatggagaaa gtttgagtgg tctggagaaa 52441 agatccaacc agccacaaca tttccttaag tcaaagccta atccagagca agactctaac 52501 tctcttcaat gctatgaagg cggagagagg tgaggaagct gcagaagaaa agtttgaagc 52561 tagcggaggt tggtttgtga ggtttaatga aagacaacat ctccataaca taaaaatgca 52621 agatgaagca gcaagtgcaa agggagaagc tgtggcaagt tatccagaaa atctagataa 52681 gataattgat gaaagtgtct acacgaaaca acagattttc agtgtagaca aaacagtctt 52741 atgttggaag aagatgccat ccaggacttt cacagctaga gaggagatgt caaggcaagc 52801 tgcaaagctc cacaggacag gctgactctc tttttagagg tgaatgcagc tgatgacttt 52861 aagttgaagt aaatgttcat ttactatttt gtaaatcctg gtgtcattaa gaattatgcg 52921 aaatctactc tatctgtgct ccataaatgg aacaataaag cctggatgac aacacatctg 52981 tttacagcat ggtttactga atatttcaag cccactattg agaactattg ctcagaaaaa 53041 aagattcctt tcaaaatatt actgctctgc accatgtcga tcaagagctg tgttggagat 53101 gtacgagaat attcatgttg ttttcatccc tgctaacaca aacatccatt ctgcagtcca 53161 tggaccaaga ctttcaagtc ttattaagaa atatatttca taaggctatt aagaaatagc 53221 tatatatata tatatataca gccttatata gtttatatag ctaccattga tagtgattcc 53281 attgatggat ctgagcaaag caaattgaaa agcttctgga aagtagtcat tattctagat 53341 gccattagga acatttgtaa ttcatgggag gaggtcaaaa taccaacatt aacaggagtg 53401 tgaaagacat tgattccaac ccccatagat gactttcagg ggttcacgtc ttcagtggag 53461 gaagttgctg tagatgtggt ggaaacagca agagaactag aactagaagt ggagcctgaa 53521 gttgtgactg aattgccgca ctctcatgat caaacttgaa cagatgaaga gttgcttctt 53581 acatatgagc agtgaaagtg gtctcttgag atggaatctc ctcctggtga agatgctgtg 53641 aacacggtta aaatgacaac aatcgattta gaatattaca taaatttagt taataaagca 53701 gtggcagggt ttgagaggat tgactccaat tttgaaagaa gtgggtaaaa tgctatcaaa 53761 tagcatcaca tggtatggag aaatcttttg tgaagggaag agtcgaccaa ggtggcaaat 53821 tgcattgtca tcttatttta agaaattgcc acagccaccc ccagctttag caaccaccac 53881 cctgatcagt aagcagccat caacatcaaa acaagaccgc catcctcttc agcaaaaaca 53941 ctatgacttg ctgaaggctc agatgatggt tagcattttt agcaatacaa tatttttaat 54001 taaggtatgc acattggttt ttctgacata atactattgc atacttaata gactacagta 54061 taggataaac acaactttta tatgcactgg gaaaccaaaa aggttatttt tgagatattt 54121 gctttactgt ggtggcctga agctgaactc acaatctcac caaggcgggc ctgaacctct 54181 ttagctaact ggccactgcc acagccact ctgtgttgg caagatgccc cagagtggca WO 00/09525 PCT/US99/17712 EPI-109 1152 54241 ggcacact gtggtcacat ccaagggcct agatatggtg ggggczzaa atggatcta. 54301 atatqtgaga uctctctttg atttgacttc ttccaaccca ccattttwcg ggtgctgggc 54361 tcatctcacc cagaaagtag gacccaatgt gacagttcct gcccaqtzcc ctcctgtggt 54421 agccacttga cccaggggca ctcttgatcc ttgcagcctc acttacacac cctatctcta 54481 cccctattaa ctctctccaa tccccactcc ccctgctcag cttgtctgct gcccagtggg 54541 ggccccaccc atgctggcct ctccttttgc aagtccccat tcctcatatg gtttcttcag 54601 agcccctttc tttggctttg aggagagatg ccctcacccg cttccccacc aatcctgccc 54661 acttctacaa tccattcatt atcctaattg cctccgtata cagactaag tgagaggagt 54721 tgatgtgata ggtgtggata cagggctggt gctgtcatct tctagtaagc cctgggagag 54781 gtgtctgagc ccaggtgtca gtggttttct ttggaactgt gagtgcataa cacttctttg 54841 ccttcagcct taggccatag ttgctagttc tgggacaacc agaaaaaccc tacataatct 54901 cgtgttatgt gcagagctga gtatagagct ccaggtatga tctgactcac ttaagatcac 54961 agtgagtcta ttgtattgtt gaactgttaq cttagacatc tgttactgta cctacatggc 55021 actaqcctca cgcctagaca ccgatctgaa agaaatcccc taaatgcata gagaagactt 55081 ctcagctgag ctaaggggct cccaccaggt ttgagcctat ctaatgaatc catgaggtag 55141 acagcctgca catgtccact tggtttgatg aattgcacaa atccctatgg gggatgtggt 55201 tcatgggctg ggaagtgggt taccctggga aaggtctaca ggacaaaggC agggatggag 55261 acaacagcat ggtgagttcc caacccaccc acgatgatag gtgtctgagg cagaaggtaa 55321 agaggctgtc acctggtggg tgtcataaga ctcaagtgtc attgttgagg cacatgggta 55381 acaaagcgtg gcactggatg ggggtagatt cttcctattt ctgtgaggat cagggggact 55441 ccctggctct cctgctaaag gtggctctag ggacaggaag agtgtacttc ttgacaggga 55501 tgtcagagca ctgatggtga caatcagtgt gacactgctc acatgactga acaaccgaga 55561 agagcccgac tgtctactga acaacgggaa gagcccgact gtcaatgacg gagctctgtt 55621 aaatatagtt aaggctattt tgttgaatga atgaagccag acaggaaaga ggacagtatc 55681 tttaatccat ttatagaagt taaagacagg cttatttaat ctctatgaag acagagtggc 55741 ccttacctct gggtggagca aaaggcacct tctgaagtga tagggatgtt ccttatcatc 55801 ttgatccgga gtggtagtta catgcatgta tgcatatcaa aactcaccaa gctgtaccac 55861 taagtgtgtt cttcctcaat aaaaataata aagaactaca cttataaaga attttttaat 55921 aatataggaa aatgtctaca ctataatctt tagctaaaaa aaaaaaaaaa gaagccgcct 55981 acagaatggt atatgcatga gaacaattaa tCgaaaagtg catgggaaaa gtcaggattg 56041 aaacatcatg ttttaaaaga cattgttttg atactgtgag aatgtaccta agtttttcct 56101 tttttctgtt tttcccaatt ttatacaatg agcatgtgtt ggttttataa ttagacattt 56161 tgtttgtttg gtttggtttt gagacacagc ttgctgtcac ccaggttgga gtgcaatggc 56221 ccaatcttgg ttcactgcaa cctccatctc ctgggttcaa gagattctcc cacttcagcc 56281 tcctgagtag ctgggactat aggggcgcac caccacatcc agctaatttt gtgtattttt 56341 agtagagatg gggtttcacc atgctggcca ggttggtctc aaactcctga cctcaagtta 56401 tccactcgcc ttggcttccc aaagtgctgg gattataggc atgagccacc gcacttggcc 56461 tagacatttg tttttaaaaa taaaagattc atttgctctt tttacagccc gtctcactgt 56521 tgactgatat tgaccaggag tcaactcagg CCCCagggat tttcacaaca gctgctgtat 56581 ggcagggttt ctgctcactg tgctcatgta gttggccctt gcacccaaag tgaataatta 56641 acattctccc catcctgttg acgatgctct gaaaatatgg tccagaaatg gtgtgagcaa 56701 ggagacagca aagcaatgct tggaacatag gtgcagtgac tagacatggg gcagctgttt 56761 aaagacaaaa aggccccaaa aaggagggat ggcacgaaac accctccaat atgggcatgg 56821 agtctagagt gacaaagtga tcaaaagttc atttcctatg gggtgtccga atgtacttaa 56881 taataaaaag agaacaagag ccatgcaaac tgagagggac aaagtaaaaa gagtagcaga 56941 caccaagcaa ctaagtcaca gcatgataag ctgctagctt gttgtcatta ttgtatccag 57001 aacaacattt catttaaatg ctgaagaatt tcccatgggt ccccactttc ttgtgaatcc 57061 ttgggctgaa cccccctgtc ctgagtggtt actagaacac acctctggac cagaaacaca 57121 aaagtggagt aacacacact gcaaagctgt gcttccttgt ttcagcctgt gaatcctcac 57181 cttgtttccc atctagccta tatttttcaa actaacttgg ccatagaatc atgtagtatt 57241 tagggtggaa gctgccccag gtctagcacg tcatttaaca gatgaggaaa tggaagcttg 57301 ggcagtggaa gtatcttgcc gaggtcacac agcaagtcag cagcacagcg tgtgtgactc 57361 cgagcctgct ccgctagccc acattgccct ctgggggtga gtatgtcttc acatcctcca 57421 ataccctaat gacagacaaa cagaacatgg caaagcctca gctctgcatg gtqaaagtaa 57481 gaaccagcaa ttgccacaaa cagaaataca gtgttggtcc ggcagcctcc gggggttctg 57541 cacaagtgga ttaccagtga atacaaggct atctatcttt cgaaaaacca acgttgtatt 57601 tatgctattt tctataaaat tttatattaa tttatttgtt acctattttt gaactctttc 57661 aaaagcacac tttatatttc cctgcttaaa cagtcccccg agggtgggtg cccaaaaggc 57721 tctacacttg ttatcattcc ctctccacca caggcatatt gagtaagttt gtatttgggt 57781 ttttttaaaa cctccactct acagttaaga aaactaaggc acagagcttc aataatttgg 57841 tcagagccaa gtagcagtaa tgaagctgga ggttaaaccc agcagcatga ctgcagttct 57901 taatcaatgc cttttgaatt gcacatatgg gatgaactag aacattttct cgatgattcg 57961 ctgtccttgt tatgattatg ttactgagct ctgttgtagc acagacatat gtccctatat 58021 ggggcggggt tgggggtgtc ttgatcgctg ggctatttct atactgttct ggcttttccc 58081 aagcagtcat ttctttctat tctccaagca ccagcaatta gctttacctt ttcagcttct 58141 agtttgctga aactaatctg otatagacag agactccggt gaaccaattt tattaggatt 58201 tgatcaaata aactctctct gacaaaggac tgctgaaaga gtaactaaga gtttgatgtt 58261 tactgagtgc atagtatgtg ctagatgctg gccgtggatg cctcatagaa tcctcccaac 58321 aactcatgaa atgactactg tcattcagcc caatacccag acgagaaagc tgagggtaag 58381 acaggtttca agcttggcag tctgactaca gaggccactg gcttagcccc tgggttagtc 58441 tgcctctgta ggattggggg cacgtaattt tgctgtttgg ggtctcattt gccttcttag 58501 agatcacaag ccaaagcttt ttattCtaga gccaaggta cggaagccca gagggcatct 58561 tgtggctcgg gagtagctct ctgctgtctt ctcagctctg ctgacaatac ttgagatttt 58621 cagatgtcac caaccaccaa gagagcttga tatgactgta tatagtatag tcataaagaa 58681 cctgaacttg accatatcact tatgtcatgt ggaaaatttc tcatagcttc agatagatta WO 00/09525 PCTIUS99/17712 EPI-109 1153 58741 tazctggaat gaagaatcct gccacctata tarctggcat ag-7:aagtc ctcataaatg 58801 ctzactggzt tgaagggcaa caaaatagtg aacagagtga aaazcccac taaaccctq 58861 ggtccagaaa aagatgggaa acctgtttag ctcacccgtg agcccatagt taaaactctt 58921 tagacaacag gttttttccg tttacagaga acaataatat tgggzggtga gcatctgtgt 58981 gggggttggg gtgggatagg ggatacgggg agagtggaga aaaaaggggc acagggttaa 59041 tgtgaagtcc aggatccccc tctacattta aagttggttt aagtzggctt taattaatag 59101 caactcttaa gataatcaga attttcttaa ccttttagcc ttaczgttga aaagccctgt 59161 gatcttgtac aaatcatttg cttcttggat agtaatttct tttac:aaaa tgtgggcttt 59221 tgactagatg aatgtaaatg ttcttctagc tctgatatcc tttatzcttt atattttcta 59281 acagattctg tgtagtggga tgagcagaga acaaaaacaa aataazccag tgagaaaagc 59341 ccgtaaataa actttcagac cagagatcta ttctctagct tatttaagc tcaacttaaa 59401 aggaagaact gttctctgat tcttttcgcc ttcaatacac ttaataattt aactccaccc 59461 tccttcaaaa gaaacagcat ttcctacttt tatactgtct atataattga tttgcacagc 59521 tcatctggcc agaagagctg agacatccgt tcccctacaa gaaaczctcc ccggtaagta 59581 acctctcagc tgcttggcct gttagttagc ttctgagatg agtaaaagac tttacaggaa 59641 acccatagaa gacatttggc aaacaccaag tgctcataca attatcttaa aatataatct 59701 ttaagataag gaaagggtca cagtttggaa tgagtttcag acggttataa catcaaagat 59761 acaaaacatg attgtgagtg aaagacttta aagggagcaa tagtazttta ataactaaca 59821 atccttacct ctcaaaagaa agatttgcag agagatgagt cttagctgaa atcttgaaat 59881 cttatcttct gctaaggaga actaaaccct ctccagtgag atgccttctg aatatgtgcc 59941 cacaagaagt tgtgtctaag tctggttctc ttttttcttt ttcczccaga caagagggaa 60001 gcctaaaaat ggtcaaaatt aatattaaat tacaaacgcc aaataaaatt ttcctctaat 60061 atatcagttt catggcacag ttagtatata attctttatg gttcaaaatt aaaaatgagc 60121 ttttctaggg gcttctctca gctgcctagt ctaaggtgca gggagzttga gactcacagg 60181 gtttaataag agaaaattct cagctagagc agctgaactt aaatagacta ggcaagacag 60241 ctggttataa gactaaacta cccagaatgc atgacattca tctgtggtgg cagacgaaac 60301 attttttatt atattatttc ttgggtatgt atgacaactc ttaat-gtgg caactcaaac 60361 tacaaacaca aacttcacag aaaatgtgag gattttacaa ttggctgttg tcatctatga 60421 ccttccctgg gacttgggca cccggccatt tcactctgac tacazatgt caccaaacat 60481 ctgatggtct tgccttttaa ttctcttttt gaggactgag agggagggta gcatggtagt 60541 taagagtgca ggcttcccgc attcaaaatc ggttgcttac tagctgtgtg gctttgagca 60601 agttactcac cctctctgtg cttcaaggtc cttgtctgca aaatgtgaaa aatatttcct 60661 gcctcataag gttgccctaa ggattaaatg aatgaatggg tatgatgctt agaacagtga 60721 ttggcatcca gtatgtgccc tcgaggcctc ttaattatta ctggcttgct catagtgcat 60781 gttctttgtg ggctaactct agcgtcaata aaaatgttaa gactgagttg cagctgggca 60841 tggtggctca tgcctgtaat cccagcattc taggaggctg aggcaggagg atcgcttgag 60901 cccaggagtt cgagaccagc ctgggcaaca tagtgtgatc ttgtatctat aaaaataaac 60961 aaaattagct tggtgtggtg gcgcctgtag tccccagcca cttggagggg tgaggtgaga 61021 ggattqcttg agcccgggat gatccaggct gcagtgagcc atgatcgtgc cactgcactc 61081 cagcctgggc gacagagtga gaccctgtct cacaacaaca acagcaacaa aaaggctgag 61141 ctgcaccatg cttgacccag tttcttaaaa ttgttgtcaa agcttcattc actccatggt 61201 gctatagagc acaagatttt atttggtgag atggtgcttt catgaattcc cccaacagag 61261 ccaagctctc catctagtgg acagggaagc tagcagcaaa ccttcccttc actacaaaac 61321 ttcattgctt ggccaaaaag agagttaatt caatgtagac atctatgtag gcaattaaaa 61381 acctattgat gtataaaaca gtttgcattc atggagggca actaaataca ttctaggact 61441 ttataaaaga tcacttttta tttatgcaca gggtggaaca agatggatta tcaagtgtca 61501 agtccaatct atgacatcaa ttattataca tcggagccct gccaaaaaat caatgtgaag 61561 caaatcgcag cccgcctcct gcctccgctc tactcactgg tgttcatctt tggttttgtg 61621 ggcaacatgc tggtcatcct catcctgata aactgcaaaa ggctaaagag catgactgac 61681 atctacctgc tcaacctggc catctctgac ctgtttttcc ttcttactgt ccccttctgg 61741 gctcactatg ctgccgccca gtgggacttt gqaaatacaa tgtgtcaact cttgacaggg 61801 ctctatttta taggcttctt ctctggaatc ttcttcatca tcctcctgac aatcgatagg 61861 tacctggctg tcgtccatgc tgtgtttgct ttaaaagcca ggacggtcac ctttggggtg 61921 gtgacaagtg tgatcacttg ggtggtggct gtgtttgcgt ctctcccagg aatcatcttt 61981 accagatctc aaaaagaagg tcttcattac acctgcagct ctcattttcc atacagtcag 62041 tatcaattct ggaagaattt ccagacatta aagatagtca tcttggggct ggtcctgccg 62101 ctgcttgtca tggtcatctg ctactcggga atcctaaaaa ctctgcttcg gtgtcgaaat 62161 gagaagaaga ggcacagggc tgtgaggctt atcttcacca tcatgattgt ttattttctc 62221 ttctgggctc cctacaacat tgtccttctc ctgaacacct tccaggaatt ctttggcctg 62281 aataattgca gtagctctaa caggttggac caagctatgc aggtgacaga gactcttggg 62341 atgacgcact gctgcatcaa ccccatcatc tatgcctttg tcggggagaa gttcagaaac 62401 tacctcttag tcttcttcca aaagcacatt gccaaacgct tctgcaaatg ctgttctatt 62461 ttccagcaaq aggctcccga gcgagcaagc tcagtttaca cccgatccac tggggagcag 62521 gaaatatctg tgggcttgtg acacggactc aagtgggctg gtgacccagt cagagttgtg 62581 cacatggctt agttttcata cacagcctgg gctgggggtg gggtgggaga ggtctttttt 62641 aaaaggaagt tactgttata gagggtctaa gattcatcca tttatttggc atctgtttaa 62701 agtagattag atcttttaag cccatcaatt atagaaagcc aaatcaaaat atgttgatga 62761 aaaatagcaa cctttttatc tccccttcac atgcatcaag ttattgacaa actctccctt 62821 cactccgaaa gttccttatg tatatttaaa agaaagcctc agagaattgc tgattcttga 62881 gtttagtgat ctgaacagaa ataccaaaat tatttcagaa atgtacaact ttttacctag 62941 tacaaggcaa catataggtt gtaaatgtgt ttaaaacagg tctttatctt gctatgggga 63001 gaaaagacat gaatatgatt agtaaagaaa tgacactttt catgtgtgat ttcccctcca 63061 aggtatggat aataagtttc actgacttag aaccaggcga gagacttgtg gcctgggaga 63121 gctggggaag cttcttaaat gagaaggaat ttgagttgga tcatctattg ctggcaaaga 63181 cagaagcctc actgcaagca ctgcatgggc aagcttggct gtagaaggag acagagctgg WO 00/09525 PCT/US99/17712 EPI-109 1154 63241 ttgggaagac atagggagga aggacaaagc tagatcatga agaaccttga cggcattgct 63301 ccgtctaagt ca.aagctga gcagggagat ctggttggt gttgcaaaag gtttactctg 63361 tggccaaagg agagtcagga aggatgagca tttagggcaa ggagaccacc aacagccctc 63421 aggtcagggt gaagatggcc tctgctaagc zcaaggcgtg aggatgggaa qgagggaggt 63481 attcgtaagg ataggaagga gggaggtatt cgtgcagcat atgaggatgc agagtcagca 63541 gaactggggt ggatttagtt tggaagtgag ggtcagagag gagtcagaga gaatccctag 63601 tcttcaagca gattggagaa acccttgaaa agacatcaag cacagaagga ggaggaggag 63661 gtttaggtca agaagaagat ggattggtgt aaaaggatgg gtctggtttg cagagcttga 63721 acacagtctc acccagactc caggctgtct ttcactgaat gcttctgact tcatagattt 63781 ccttcccatc ccagctgaaa tactgagggg tctccaggag gagactagat ttatgaatac 63841 acgaggtatg aggtctagga acatacttca gctcacacat gagatctagg tgaggattga 63901 ttacctagta gucatttcat gggttgttgg gaggattcta tgaggcaacc acaggcagca 63961 tttagcacat actacacatt caataagcat caaactctta gttactcatt cagggatagc 64021 actgagcaaa gcattgagca aaggggtccc atagaggtga gggaagcctg aaaaactaag 64081 atgctgcctg cccagtgcac acaagtgtag gtatcatttt ctgcatttaa ccgtcaatag 64141 gcaaaggggg gaagggacat attcatttgg aaataagctg ccttgagcct taaaacccac 64201 aaaagtacaa tttaccagcc tccgtatttc agactgaatg 9999t99999 gggcgcctta 64261 ggtacttatt ccagatgcct tctccagaca aaccagaagc aacagaaaaa atcgtctctc 64321 cctccctttg aaatgaatat accccttagt gtttgggtat attcatttca aagggagaga 64381 gagaggtttt tttctgttct ttctcatatg attgtgcaca tacttgagac tgttttgaat 64441 ttgggggatg gctaaaacca tcatagtaca ggtaaggtga gggaatagta agtggtgaga 64501 actactcagg gaatgaaggt gtcagaataa taagaggtgc tactgacttt ctcagcctct 64561 gaatatgaac ggtgagcatt gtggctgtca gcaggaagca acgaagggaa atgtctttcc 64621 ttttgctctt aagttgtgga gagtgcaaca gtagcatagg accctaccct ctgggccaag 64681 tcaaagacat tctgacatct tagtatttgc atattcttat gtatgtgaaa gttacaaatt 64741 gcttgaaaga aaatatgcat ctaataaaaa acaccttcta aaataattca ttatattctt 64801 gctctttcag tcaagtgtac atttagagaa tagcacataa aactgccaga gcattttata 64861 agcagctgtt ttcttcctta gtgtgtgtgc atgtgtgtgt gatgtataca aagagagaga 64921 taattgtatt tttgtatttt cttttaaata atttttaaaa ttgacccttt tcctgagaca 64981 aattgccaga atagtttgta tttagagatg gtacctctaa gagtaaggtt gctggttgct 65041 gagcaattga cttgaaaact tttaaaattc aaattttaat tccactactc aaaagaattg 65101 ccatgtttta aaaaagagaa ttggtgccat aagttagttg tctatgtttg aaaatgaaga 65161 agatatgcaa cgtcatggcc tggtcactta cccgcagccc tgagttgtag gcacatcata 65221 tgtgagaatg aggatgcttt tctttcattt aaaatccctc cccaaaactt ggctctaatt 65281 gcagtcatga caatcatgta catttggatt tatgtgcacg agtctcttac cctgagagag 65341 gacaggtgct acaggtggag gggacccgtc tgggtcacgt tcacattttg aacatgctgg 65401 ttttcagtca ctgcacactc atctcccagc gcaggtcatg ggcagcagat gcaaaagctg 65461 cccgtggtcc tatttggagg tgcatgaaat gagcagaaga cagaatagct tgatctgact 65521 agaagggcag cttgtcccta ccaagacttg aaggattgcc tttcatctgt tagggtaaaa 65581 ggtagaatga accaaggaag ggcaggaggg ggctggggtt agggtagaag gaaggggcca 65641 tggagaaggg agatccatcc cataggagga aggcagtgcg gcagggaggt ttgaaggtat 65701 cagcttttgt ggctgacata catgcagtca tgtcaattgc tcgtttttcc ttttccatct 65761 tattaaatgt cttccaatgt tagcacgaag aaaagctatt tgcagtgttg ccagcctttc 65821 cagagcccgt ccccattacc tccccaggcc catgccttta ctccttggag tttcaactca 65881 cgaccttcag gatctgactt tattcaccaa ctctggggtg aacgtacctt ctgtctccac 65941 ccagaggtct ctatcaaaga ggagattgca tgccatggat aaagtcaaag tagaggtgac 66001 tgtccttagg aagagtaatg tgaaaattca taaactggga ttctgtttac attttgtact 66061 ccaggggttc ttagtttaaa tcgctctgaa taaattaaga tgcaatggca tttcaactgt 66121 tatgattaaa tttacaaatc atttattttc tatcacgggg agagatagag ctccaaatgc 66181 aaacataact gctcaagtgt taacacttat aatgaaaaca taagaattac caccaactac 66241 cctgggggct agaagcagaa atgtgaacca gaaaacaaat catgaacttt cctttttttt 66301 tttgagatgg agtctcgctc tgttgcccag gctggagtgc aatggtgcga tctcggctca 66361 ctgcaaccac tgcctcccgg gttcaagcaa ttctcctgcc tcagcctcct gagtagctgg 66421 gactacaggc atgcaccacc acgcctgggt aattttttgt atttttagta gagacagggt 66481 ttcaccgtat tagccaggat gctctcgatc tcctgacctc gtgatctgcc cgcctcggcc 66541 tcccaccgaa gtgctgggat tacaggcatg agccactgtg cccggccaac aaatcatgaa 66601 ctttctaact gcagttcctt gtagcttgtt aacacatcca cttacttatt gtcagagtac 66661 gtggagattt tccacaaccc tcggggataa ggctgaacag aagaggcaaa aacgtgaaaa 66721 catttcgata gctcctatac tttgaaataa aattcactgt aaaagttgct tgtatttttc 66781 caaaacagag tcaaccctta atatttaaga ttctgtatac aaatacatat ttttatataa 66841 ttaatatata ttgtcatatg acatatatct ttatattaat atgcatgcat ataatatata 66901 tttccttcct aattttctat aagcaatttt acaagactga cttctatttg cctccttatt 66961 gttactacgt ggtttgataa tccgttttgt gtcattgtga ttctgtcatg ttttggggac 67021 ttatttttgt ttctctgggt ggtcactagt ttttttaaag cattcatgga agagtgtgaa 67081 tcttttacaa gctaggaagc catggcaagc cttgggtcat actgcccccg cgaggccaca 67141 ttggcaaacc agcaagggtg ttcaacttcc agacttggcc atggagaaga catacgagga 67201 ggcttttcac attcagctct ttaatgtttg tctctgccgg caccatccca gttgtgaata 67261 agaggtattt ccacagcggc tcagggtagg tagtgcacag ctcacattca tcatttctga 67321 aaaccgagag gagtctccat tcggggtaca ggttgatgcc tgtcgtggaa tgaaggttcc 67381 aacacccaga ccaatctctg cagtgtgctg ctctcatgag cttgcaacaa gatcagaaaa 67441 tgttttgtga ctaagcattt ttcatattgc ataaaatgct tcaagctcct cccttgtttc 67501 tctctataat cctgtatatc tgatgattgt gggtaccaag tgtttgaaat aatcaaatgt 67561 gatttgatgt tggtaaattt cttttttttt ttttttttac ttctattttt tttattatac 67621 tttaagtttt agggtacatg tgcacattgt gcaggttagt tacatatgta tacatgtgcc 67681 atgctggtgc actgcaccca ctaactcgtc atctagcatt aggtatatct cccaatgcta WO 00/09525 PCT/US99/17712 EPI-109 1155 67741 tcccccccc ctcccccac cccaccacag toccaaagt gtgatartcc ccttcctatg 67801 cccatgtgat ctcattattc aattcccacc tatgagtgag aatatacggt gtttggtttt 67861 ttgttcttgc gatagtttac tgagaatgat ggtttccaat ttcatccatg tccctacaaa 67921 ggacatgaac atagcaaaga cttggaacca acccaaatgt ccaacaatga tagactggat 67981 taagaaaatg tggcacatat acaccatggt aaatttcttt atcattcgca ctctcctttc 68041 tctattattg ttattgtaac tgaaccgcag attagtcact cattgcttgc agaatccaat 68101 taacaagagc gaggtcagat ataaagaaaa tgatttattc caaacctcct tcagggaaga 68161 ggtgcagcct cctgcctcta aatgcactgc ttcgccaggc gtggtggctc acacctgtaa 68221 tcccagcact ttgggagacc gaggagggca gatcacttaa ggtcaggagt tcaagaccgg 68281 cctggccaat atagtgaaac ccctgcctct actaaaaata caaaaaatta gccagacgtg 68341 gtggcgggtg cttgtaatcc cagctactcg ggaggctgag gcaggagaat cgcttgaacc 68401 tgggagqtgg aagttgcagt gagctgacat ctagccactg cactccagcc tgggtgacag 68461 agtgagactc tgtctcaaaa taaataaata aataaataaa taaataaata gtaaatgcac 68521 tgctttgctt ttggagcaga aagcaggcac tttgaaaagg caggggagga agtgagcaag 68581 ggcagggggt ctgcacactg gcatggtgcc tgatctatcc aggcagttga attggcactt 68641 tcataggcag aaataagttg aaaaagtggc ctaaaactct ctaggtggga gtggatagtg 68701 ggcatgcctt caacctgcct ttctggaggg tgagttccat ggcaaccccc tgaagggtga 68761 gagttccatg gagatcatgc tttggtctgt aaatcagctg ttaactCtct agaaagttct 68821 gtcttggagc atatagttag atgaacttgc cctgtaaaga atgtctggtg aaggggaagt 68881 aaaaggtgag atttgcattt ctaaagggct aagtagaacg tggggtacaa gaggaaagga 68941 gaaaagagaa aataatttaa aaaataattg taacttattc ccttttactt agaaaaaagg 69001 gaatactcag ttacattatc acctcgttta catcaaaccc tcttatggaa tcctatggtt 69061 tgaaaacaaa aaggttgttg aggaccagtg agcccaaccc ctttgcttta taaatgaaga 69121 gcattgcctg ccctaagccc cagagactct gatgtcgtgg gtctggagtg ggctccaaca 69181 gcggcatgtt ttgatggtgc ttcccagtgg cacgccagcg atgagccttt gagtagggaa 69241 agtaggagca ctcgtgactc ccttcacgat cagcacctgt gtgctaataa attcacaaaa 69301 gccaacatat tggagtcact cagggagttt tacaaatagt gaggttaaat ccaacctcaa 69361 atagttctga ttcgatctgc ctgcattgct gccctgtggt tccccactgt agaagctccc 69421 caggtgattc taagtgtagc caagtctgag aaatactgcc taaagcctgt tggactgaca 69481 gcaagggctg ttgtctgagc aagactttgc ctggcctggg gtggcatgtg caccaggaag 69541 agtctcaact ttcataacag aacattcccc aagctggttt ttttaaagca tgtgaatcta 69601 gacttcattg gcaataccaa agatctgtat ttgaggctcc aagtatttca ctttcatttt 69661 tggttttggg ttatgttttc acccttcctt tccaagtgaa aagtaaacag aagtgggatg 69721 tctggcgccc atgctgagct tggcaacttc aaattcaata gagaagaagt ctcttgtata 69781 gaaaagggcc tgtctgagat gtttctcaaa taaatataga ttttgcttat gtggctaaag 69841 gattcttctc cccccatttc cttatccctg cagtgagcca tccttcttaa ctctttccat 69901 gaaagcatta ttcctgaaga actgggaact catgccagcc ctgatcaggc aatgataatt 69961 ctgcagagaa ttagaattta gatttaaatt gtcaactctt atacatcctg gcatatggtt 70021 taaacacatg tacacacaca caaacacctc ctactattta ctgaagagca gatatctgat 70081 aacttaatct ttttggtttt gagtcaagac aattcctcct tttgaaactg cataccgctg 70141 aatataataa aatgtaatta agattaaaaa taagaaacta atgggagaat ttcaatattg 70201 tctctgttca ctttaaaatt cctctactta ggtttactgc cattaccaaa gactattcaa 70261 aaatcctttt taggagaatc ctaatggttt cctgacatat aatcaaataa ggactctgtt 70321 gattggctaa ctcaatcttc ctgtgccaaa aagcagagcc cagcagagaa gagggcaggg 70381 acttgaaagt cagactgact cgagttccag ccttggggct gtgggagctt gggcaagtga 70441 cttaacgtct ctggctctca ggatctaaaa ggatttccag tagtaatttg gggtgttact 70501 gatacaggag ctaaaaagaa attatttagg tggttagtga gggtcagaga gtcctcggta 70561 agatttgcct tttaacaaaa agcagcccca aaatcatttg tttgctaaca aagagaagcc 70621 tgtaaaattg agctgcagac atagataagc aagctggaag cttgcacggg tgaatgccgg 70681 cagctgtgcc aataggaaaa ggctatctgg gggccaggca tgttcaacat ggattctcca 70741 tcttcccttt tctttgtcaa ccaagtgtac agtaaaggaa caggcaacat ggcacgggcc 70801 aggtagagaa cccttctgca taataaaaga ttagggtgag atggccagct tcttcccgtg 70861 ctatgtaaat ggcatacctg gtccaaccag tcttttgggc cctgtgtaaa tcagacaccg 70921 cccctcaag ttagtctata aaaccccatg cattttaccg tgaaactggg agatccactc 70981 ggaaccccct cctgcacgag agaccttttc tcttttgcct attacacttc cgctcttaaa 71041 ctcactgctc atgtgttagc atccttgatt tccttggcat gaggcaatga accttgtgta 71101 ttaccccata caaatgatgc tgcttcatta ctaatagcaa cctgacaggg ttgtgttggg 71161 gtataaatta tctagaccag ggagatccaa tataattttt ttgtaatgac gggaatgctt 71221 tgtatctgca tcatccaaaa tggtagccac caggccaggg tgaaatgtgg ccagtgtgac 71281 tgaggaactg aatgttttcc atgatttaat ttaaatgtgg ccaatggcta ctgtaggaga 71341 cagtgtgagt ctggcatatt ataaataata aatattaata taatttgaac tttggcatca 71401 gtgtttccta gatttgaatt actatgcaag ttqcttactg tttccaagcc tcagctttct 71461 aatctgtaat tggggctaat aatagtatct gccttacagg tttgttcaga ggataaatga 71521 gaaattgcat gttgagggct taacacagtg cctggcacat aaaagctctg gtaacagtta 71581 gccactttaa taatttgcta ataatggcta tttcttcttc agattaggat gtgctccccc 71641 aaacagtgca cttagacata gcgggcaatc cagctcactc tctgcagtga gagagaagca 71701 ctggccgacc agagtcagcc aggggctcat gggtatgaaa tcaacagcat gattttgtaa 71761 gtaatggatg gaaagggcct cacaacttta tggcactgtg ttcaatttgc ttggtcttct 71821 gtagctcctt ttgaaagcct tttagggtgg attaacctgc taccaataat tctggtcaga 71881 tgtagactcc atagctcaaa gcaaactgag agagtgaggg cagcaggcca attccccacc 71941 ccttccttct ggactctgac agaagcttac actcaaggaa gagcaagtag gaattaacgt 72001 gttaagagct aggtaagcaa aacccaatga gaagttctgg caaagctca tgggcagggg 72061 tggcttaggc acaggaaaca agtaggattt cataccacgc gcctcactct acttccgggg 72121 ccctcaccct cagctgtgcc tatgcaaagg agagcaacca ataaacccca ccgccactct 72181 cctactgtgg aggccaggga tggccagggg taagagaggg atgggaagtg tttcctccag WO 00/09525 PCT/US99/17712 EPI-109 1156 72241 ccgtcctc g agaaggagag gaaactgggc aaagcttctg tcctcctzca agcagaaaca 72301 gaaacaaaaa aaacccctaa gggggttctt acttcccctc tauztcaatt gtgcactaac 72361 catctgcagc ccaacattca gcattcattc attgattcag caaacatzga aggagggcca 72421 gctatgtgcc agatgccaac tcatgccatg aaagagagtc cctgtcctta tgaaattcac 72481 tatttagaga gaaaagcaag caaaaaggca aagtttgaaa agtactgztg aagtggcatc 72541 attgtctggg gtgaataccc gaggtttgtg gtctcacgcc aagggaatca aggactcagg 72601 cacacaaaa gtgagtttaa gagcagaggt ttaataggca aaaaaaagag aaaaaagaat 72661 agctctcttg cctgcacaaa gagaggggca cctgagtgga tcttcctgtt ttgtggtgaa 72721 atgcaaggca ttttatagac gagcttgagg aagtggtgtc tgatttactt aggacccgag 72781 aqattggtca gaccaggtgt gatgtttaca tagcatacaa agaagctggc catcccatcc 72841 taatctttta ttacgcagac ggggtctata cctggctggt gccatgtrgt ctgttcctta 72901 ctgtacacgt ggttgacaaa gaaaagggaa gatgaagaat ccatgttgaa catgcctggc 72961 ccccagatag tcttttccta ttggcacagc tgccggcatt cactcttgca agcttccaga 73021 ttgcttatct atgtctgcag cccaatttta caggttgctc tttgctagaa aagaaatgat 73081 ttgggggctg cttttcatta aaaggaaaac cttaccaagg ttaaaaagaa aaaaatttct 73141 ttttaatgcc tatgttactg tgaacagtgt cgggataagg ctctgagagc cagatgagga 73201 tgagttatcc aatccaagga tgggggtctg gaggaaaaaa tcctagagag cattgctgca 73261 gttgaataag gattagttag aagctactga gtggagcata ggagtaggaa ctcttatgca 73321 aatgtgcaga ggtgaaataa agcaaggtat agtccaggtg cctaaagtag cacagctgac 73381 ttgagataga tgatagatag gtagatagat ggatagggta catagatgat agatagatag 73441 atagatagat agatagatag atagatagat agacagacag acagacactg gtgtgagtgt 73501 gggtgtgtgt gtctggctgc gtgcatgcat tcctcctgca ggagatcagg agcagtgggc 73561 agtatggagt gacaagaaga ttgggaggta ctccttctag ccctcccctc tgctctgccc 73621 tccactggag cagaagcaaa gcatatggtg aaggggaaca aggagtctcc ccagcacagt 73681 acccgagtgc attagctatt tatcactcca cagtccccat tcacgtgtta attcagcatt 73741 tattgaatgc ttactgtttg caatgtctat gtcaagctgt caagtgtagt ttttattcta 73801 caggccacag gcacccccta actgtgttaa acaagatggt agtattgaga caggaataat 73861 aagggtggtc acaggagaat ggaagattcc aggcagcagt ttgactagta aaaaaggaaa 73921 ctgttgaaat agctgcataa tccaggggtc aataagaacc tgagaaccag ggtgtgagcc 73981 aaggctggtt aaaagcaact ggatccaata tggtgctgag tttctcctag gttttgcctg 74041 gaacctcatt atatgctcaa taacatacca aatcacacac ccaccagggc cattccattt 74101 cctggaacac tcatgtttgg tgtaaaaatg ggtggcacca cagctctgag aaatctttac 74161 ctttttcagg aaacttcatg aatattccat cctttggtta aagaaaccca taatgtagaa 74221 gccccaaacc ctactgggcg caactctctc tctcttgagt atgcctgcac ttccctttat 74281 tatttattta tttatttatt atttatttat ttatttttta gatggagtct ggctctgtca 74341 cccaggctgg agtgcagtgg cgcagtctca gctcactgca agctctgcct ccagggttca 74401 ggccattctc ctgcctcagc ctcctgagca gcagggacta caggcgccca ccacaacgcc 74461 tagctaattt tttgtatttt cagtagagat ggggtttcac catattttat tttatttttg 74521 agacagggtc tcactttgtt ggctcgctgc aacctctgcc tcccaggctc aagcaatcct 74581 ccaacctcag ccccccaagt agctgggagg acagacgtgc accaccacac ctggctaata 74641 ttttgtattt ttttttgtag agacagggtc ttgccatgtt ccccaggctg gtcttgaact 74701 cctggactca ggtgatcagc ctgcctccac cttccaaagt gctaggatta caggaatgag 74761 ccaccccacc cgaccacact cccatttctt gagtgtgtgc attttgctct gcaataaatc 74821 tctctacttt cacttttctc tgactcgtcc ttgaattcct tcttgtgaca gcgtcaacag 74881 cctggacacc aggtgcagtc aacgtctcac cagtgtttag ggacctcccc taatccactg 74941 gtatcagcat gatcagactt gctttttcag aaaaagcctt ctgtccatag accaaaggga 75001 agtgactcag agaaggggca ggaggaatca caagctccct gcctgaccag gcctggacta 75061 tggcagagac agtgagatgg tgagaaagca agggtagaca gccagccaaa tccagaatat 75121 agaaagttct acaggaaaag gtggggccaa ggtgggacag ggggaaagga attgttgcac 75181 attaacagtg caatgcagag cactggtctt gtttatgtcc aggttagaac aaaccaatga 75241 gaaagcacat ctttgagaca actggagaaa tttgaacact gactagatat aatattatgt 75301 taattatgct ttaatttggg gtacaataat gcttttgtag ctatttctaa agagtcctta 75361 tctcttaagg atacactcta aaatactagt ggattaagtt atatgatgtt tagactcttt 75421 ttaaaataat ccagtggggt gagaggcaga gggaagggag aggagcatag aggaaacagt 75481 gttggccata tgtttgtaat tgttaaaact gagtgatggg aatatggaga tttaacatat 75541 taatactatt ttctgcccat gtaatatttg aatattttca taataaaatt gagagagaga 75601 taaagaaaga aaagagaaaa gaagagaaga gagaagagat aagggaagtg gaggaaaaag 75661 agctttcttc aaggaccatt gtggtggaca caaatgaaag ataccccctt cctactatga 75721 attctaggtg tgtactaccc aagatgagtc aatcggatcc tagcttccag aaatcgtgag 75781 catgatgcag ccctacagac gcagtgccct ggaaaggaga cccatgacca tccaaggaag 75841 atgtcccatc acagaactgc cctgggtcat gtgttttcca agtccacatg tccggtagtt 75901 ccttctttcc tatgaccaat gccaccagtc ttccagcact gtcctttatt gctaggcaaa 75961 cctgagccat cctcttcttc ttgcaacttg tgcctgaagt aacatggaca caaagtcccc 76021 acttttccca cattctcaga atgaagtagt tctccctcca cactttaggt gctagaggca 76081 agtggattgc ttgagctcaa gagttcaaga ccagcctgag caacatggca aaaccccgtc 76141 tctacaaaaa atacaaaaat taactggggg tggtggtgtg cacctgcagt cccagctact 76201 caggaggcag agaaggagga tttcttgagc cctgaaggtg gttgtgttac gtgcattcat 76261 gttaagagac caccaaacag gctttgtgtg agcaattaag ctttttaatc atgtgggtgc 76321 aggcagactg agtctgaaaa aagagtcagc aaagggagat agggatgggg cggttttata 76381 ggatttgtgt aggtagtgga aaattacagt taaagggggt tgtcctcttg cgggtacagg 76441 cgggggtcac aaggtgctca gtggggagct cctgagattt attgtccagg agaaggaatg 76501 tcacaaggtc aactgatcag ttagggtggg gcaggaacaa attacaatgg tggaatgtca 76561 tcagttaagg caggaactgg gtattttcac ttctttgtgg ttcttcagtt gcttcaggcc 76621 atctggatgt ataagcgcag gtcacagggg atatgatggc ttagctcggg ctcagaggcc 76681 tgacattcct gtcttcttat attaataaga aaaacaaaac aaaatagtga tgaaatgttg WO 00/09525 PCTIUS99/17712 EPI-109 1157 76741 aggcagcgaa aattttggg ggtggtatgg agagataatg ggtgatartt ctcagggctg 76801 cttcaagcag gattaggggt gacacaggaa cctagagagt gagagagart aaactgaaga 76861 aagattttgt ggtaaggggt gatattgtgg ggttgttaqa aagagcaatt ctcatataga 76921 acgattggta atggcctgga tgcagttttg tatgaattga gaaactaaac ggaagacaca 76981 aggtctgaat aagagaagga gaaaaacagg cattaaagga ctaagaactg ggaggaccca 77041 ggacatccaa ttagagagtg cccaaggggg ttcagcataa ttatttgctt ggttggtgag 77101 ttttggtct ccatccttga gtttttttta tgttgtcata tgccaggcca gattgattta 77161 ggtaaaaaca acactcttca tttaaaaata tacagagttc tcctttctca gcagtgagta 77221 agtcaaggcc tcagcagttt tggaggaaag agaaatgcaa aggaagcaat tgtttgttaa 77281 gaaagattag aaatggctag gagagagtga gtgagattga tagtgtggtg gagatagctg 77341 aggagaggta gagggtggca taagaatggg aacgagaata agagtgagta taaaagtaaa 77401 gaaragaact tcatcagggt gaaagtattg gagggtgccc tgtcagcaaa gatcatctgt 77461 ccactccaag agggagtcaa gagtggcgga ttggggatag taccaggaga tatccactat 77521 gatggtttgg aggaaaagtg taaaCtggca gtgtaaacag gggcagggca tttatgagtc 77581 attgagaatg gtgaatagga gtatgactag acagaagata gtggagacga caaattttgg 77641 gggcacagtc caaatagtgg gggtgactgc gtagagctct gttgcaaaaa gtagggtaag 77701 gataaataga cttaatagaa tgaagagatg tattaggctc ataagggtta ttattgttct 77761 tcagaaatgc gagtgagttt aagggaagta ggggtgagta cttgcgactt ccagaaggaa 77821 gaggagagat caggctggct gtctgatggg cacagcttta ttctggaaca gtgaatccaa 77881 tggggagggt cgtgcagacg gatggcagtt ggggtgctat aaatgaccag gtagggtcca 77941 gtccatcaaa gctgtagagt gtgaggggtc agacttgaca aggactgatt gcccagctaa 78001 ggtatcttca catggctggg agtttggagg aggcaagaga agattagcag cctggcgaat 78061 ttcctgtcta gcctgctgga ggactggaag ataaaggcaa caggtcgtgg gcctggatcc 78121 tgtgtgagga ctctagcagc acagccttgt atttcagctg tgtgtaagga aaaaggatgg 78181 gacgagtcgg ggagtgctag cgtgggagct gtctccaggt cctttttgag agagtgaaag 78241 gaagaatggg gaaaagactt atggtctatg ggattagtta aattactt tgtgagctag 78301 taaagtggtt tgattaggat agcaaagccc ggtatccaaa gttggaaata tccaacaatg 78361 cctaagaagg aagggagttg ttgtttggtg gtgggggttg gggtctggga gattaactga 78421 acagagtctg caggaagggt atgtgtatgt tgatggagca ttataccaag ataggtaatg 78481 ctaggggaag aaatttgtgc ctcagagggc aatactttgt acccctttga gtaaagatgt 78541 tgaagaagca ggctagtgtc ctgctgggaa gattggtaag aggggCtgca aagaagaaga 78601 tcatcaacat attgaataag gtgggaggta gatgggtgaa aagaaagcag atcatgagaa 78661 agggcctggc caaagtaatg tgggctgtcc ctgaagcctt ggggtagaaa aatccaggtg 78721 agttgttggg actggtgggt gtcagagtca gtccaagtaa ggcaaaaaga ggctgggagg 78781 agggatgcaa ggggatagta aagaaggcat ctttgaggtc gataacagaa tagagttgtg 78841 gaagggtgta ttgaagatag gagggtgtac gggtttggca ctataggatg gatgggaagg 78901 acgatttgat caacaagacg aagatcctga acaaacctgt aagacttgtc cggtttctgg 78961 acgggtagga taggggagtt gtaaggagaa tttgtaggct ttaagaggcc atgttgaaac 79021 aggcaggtga taacaggctt taaccctttt aaagcctgct gtgggatggg atattggcat 79081 tgagcggggt aagggtgatt acattttaat gggatgataa ggggtgcatg atcggttgcc 79141 aaggtaggag tagaggtttc ttatacttgt ggattaaggt ggggagatac aaggggagga 79201 tgtgaaacag gtcttgagtt gggtaaaagt gcagcaaaga gatgtggctg cagcccagga 79261 atactcaggg aagcagataa tttggttaaa atgtctcagc ctattaagga agctggacag 79321 gtggggataa ctaaaaaagt gcataaaaga atgttgtcca agttggcacc agagtggggg 79381 agttttaagc ggtttagaag cctcgccgac aatacccaca acagttatgg aggcaaggga 79441 aacaggccct tgaaaagaaa gtaatgtgga gtgggtagcc tccgtattga ttaagaaggg 79501 gacagactta ccctccactg taagagttac ccaaagcatc tgtgatggtc caggaggctt 79561 ctgaggtgat caggcagtgt cagtcttcag ctgctaagct gagaagatct gggaaggagt 79621 cagtcagaga gccttgggcc agagttccag gggctctggg agtggttgcc aggcaagttg 79681 aacagtctga tttccagtgg ggtctcgcac agatgggaca ttccttggcc cagtggccag 79741 atttccggca cttgaaggaa gatcctgggg gaggaggtcc tggagaaatg cctggcccct 79801 gcagtttagg tgttttgaag ttcttgtgtg ctggagatgt ggctggggtt tctcttacag 79861 cggaggcaag taattgcaac tcagaaatat gttgtcactt ggctgcctct tttctattat 79921 tgtacacctt aaggcgaggg taattaaatc ctgttgtggg gtttgagggc tggaatctaa 79981 tttttggagc tttttctaat gtcaggagca gattgggtaa taaaatgcat attgagaata 80041 agacggcctt ctggcacctc tgggtctaga gaggtaaagt gtctaagggt tgttgccaaa 80101 caggccatgg actcagctgg gttttcatat ttgatgaaaa agagcctaaa cgctaactga 80161 tttgggagag gtcagctaaa gaaaaaggag cattaacctt gactatgcct ttagctctag 80221 ccacctctct aagaggaaat tgttgggccg gtgggggagg gctagttgtg gaacgaaact 80281 gtaagccaga ccaggtgtga ggagagaagg tgaccaaagg tttatagggt aggggagcag 80341 aggctgggga agaattggga cctggctagg cctagcgagg aacagcctgg ggaggagggg 80401 agaaatcaga tgggtccgta gaaaaggagg attcaaagga ctcagagctt ggggtggaga 80461 ctgaaggaac agacaggaga gaaagaggaa agatttggga tgagtcacat tgggagcaga 80521 gactagagag ggactgatgt gtaaagaatg cctggacgtc aggcacctca gaccatttgc 80581 ccattttacg acaaaaatta tctagatctt gtaggatgga taaatcgaaa gtgtcattct 80641 ctggccactt ggaactattg tcaagtttgt attggggcca agcagtatta cagaagaaaa 80701 taagatgttt aggtttttaa aagagtgcat aaaagaatgt tgtccaagtc catgcccttc 80761 ttaatcaata tgggagctac ccactccaca ttaccttctt ttcaagggcc tgtttccctt 80821 gcctccataa ctgttgtggg tattgatggc caggcttata agccccttaa aattacccca 80881 ctctggtgcc aacttggaga ggtcaggtgt tagtcaaagg tgttttaagt tttaagaaca 80941 caggctaagg gagaagaagg gggaatgaag cgtggaaggt tgcccatagt gaaagaggta 81001 agtttaaaga gaaaggtaga gacatggaga aggggggagg tgagcagccc tgggctgtca 81061 tgtgggttag cagccaaagc tggtgtccca gcaattgact taccaccaag ggaatgtggg 81121 tgaatgacca aggcaggcat ccccccggtg atcagacacc aaatggaatg tgggtgaaag 81181 atcaaggcag gcgtccccat gatgatcaga caccaaagga aggctgtctt cccaaatcca WO 00/09525 PCT/US99/17712 EPI-109 1158 81241 tgatccatgt tggagtttt, gagttcataa ataaaatgtg tctcctttgt ctctactaga 81301 gaggaaaaag aactggaat tgaaggacau ggagattgaa gggtagggag agaggctgaa 81361 gaagagagtg aggagaccac ttacccggtt tgaaattggt gagatgttcc ttgggctggt 81421 ctgaggacct gaggtcgtaa gcggatcttz tcatggagtg agggtgagga gaggggacca 81481 atctcccgaa ggagtcaccc tgtccggggt cttcggcacc aaatgttatg cgcatccata 81541 tgaagagacc accaaacagg ctttgtgtga gcaataaagc tttttaatca tgtgggtgca 81601 ggcagactga gtctgaaaaa ggagtcagca atgggagtta gggttggggt ggttctatag 81661 gatttgggta ggtaatggaa aattacagtt aaagggggtt gtcctcttgc aggcaagggc 81721 aggggtcaca aggtgctcgg tggggagttc ctgagactca ctgtccagaa ggaatgtcac 81781 aaggtcaatt gatcagttgg ggtggggcag gaacaaatta caatggtgga atgtcatcag 81841 ttaaggcagg agcggcctat tttcacttct tttgtggttc ttcagttgct tcaggcaatc 81901 tggatgtata tgtgcaggtc acagaggata tgatggctta gcttggactc agaggcctga 81961 caggttgctg cagtgagcca agatcacact actgcactcc tgcctgggca acagagccac 82021 aaaaaaaaaa aaaaagaaaa gaaaagaaaa aaaaagaaga agaaaaaaaa attttttttc 82081 caccaagaat ttagtaaaaa attataggga aaagtgtcac taattcaagg gaattgcact 82141 gaaaattatt cattcattca acagatatit attgagaagc aagtatgctg gtgctagggt 82201 tacaacagcg cacaaattct tgtattcaag gaatgaggta agagtatgca gataggagcc 82261 agagaggtca agaggcaatt gcaacataga grgacacgtg ctccagaaca cataggaggg 82321 cttccaggcc ccatgctggg ctatcagagc tggcttcctg caggtggtgt ggctcagcta 82381 aaacctgaga accaagaatg agccttctga tatctCaggg ttaaatcggc acaaatgaaa 82441 ccattttata accaaacaac attttccctc ctgaactgca ctttttctag aacccattta 82501 atccttccta acatgttcaa tccagccccg tgatttttca gtcaaatgca agatqcgtag 82561 gattcctttt ctgttcagtg ctccccagcc aatctttttc ccttctccca ccccacagtt 82621 actaattcca gcgtttcagt tctcagcaga ggatgacagt tccaccagga gacatcagtg 82681 ttatctggag acattttagt tgtcccagct gagggcacag tgctgctggc atctagtggg 82741 tgaaggtcaq gaatgcacct caacatcctg gaacactcag gacaatcccc agcaacaaaa 82801 acctacccat ccagaacatc aacagggctg tggctgagga gccctgctct agtgcttcct 82861 ccttactgta tcctcatcaa ggagggctct ggggcatgtc aggggctgct acaggctcct 82921 ggcagatttc ggcgacttac tccagacttg tggaacattc aggattctta gcatggccac 82981 aggagagtca ggctgtccac aagcactctc tctttcttca cccactcatt cctgtcactc 83041 taccatttcc actgccttcc caaatgccca tcgtgagtcc caccaggggc cagaacacca 83101 ctctctcaag cctccccagt ggcgcgtgca cacctggaga acatgtctca catcccccag 83161 ccagcgagac gtcctgagat tccagcactt ctcagtgtct ttcccagctt gtttgtatct 83221 ggaatggggt ggggtctctc acacaggaga aattacaagg aaaagtgtac gtgacaggaa 83281 tggaggaatt tctgtggaaa cggtgtgtga gaaaatgtag gaagaaagaa acttcaggaa 83341 atggtaagtg gcatcttgag agcagaaagt gagaagggag cagaaagaaa tggggctgga 83401 acctgggaag gagaggacag gtggggatgg ccttgcacac cgtgggcact gaggagtgtg 83461 ggcccatggc atgggtggag aggagtttca agatagggag tagattccta ttttgaactt 83521 cggattgccc ctggcgatgt ggagactgta ttggaagaag gcaagaatgg aggagagccc 83581 ctaggtggag gtttggcaat gctctctcca gaatatagca gaggcctctt ccaaggtagg 83641 aaagccctga ctggagagaa gttaatggct ctgagggctc aagggaggac ttggattatc 83701 aggactttta gggaggcata tgatcaaggc ttgggtcttg gcccattgaa atggggagca 83761 ctggttttag gatgtgggtc aattagtttg gttttcagga caggctgagt tggatatcct 83821 gggggacctc caggtggcag tgtcagggga agctggatgt gctgacactg aactcagcag 83881 agtgactgag tagagatcga catctggggt cacaggcagt ggatgccgta ggggtggact 83941 caatagctca agcagaaccc ggaggaatgc aggcagcaaa gggagcccta aagaacagtg 84001 aggagatgtg ccaagaaaga gccaaatccg ggggattggc tgtgggagag agggctgtgg 84061 gagtaagagg aagtgtcagc aacgtcaaat gttgcagaga catagagtaa ggtaagagtg 84121 gaaaaaacat ccatggaacc ctgtgatgca atcggaatgc agaaagactt tgtaactcct 84181 gcctggtctc ctcctctgcc cactcatggc aaaggaatac aaagtaatgt tccctccttc 84241 cgcctagaaa agcacaactt ctgcccccaa gccctgggct ctcctgagag gacaggacca 84301 gcctctgaag ttgaaggtcc tggttctgcc cccaagccct gggctctcct gagaggacag 84361 gaccagcctc tgaagttgaa ggtcctggtt taccagatag ggaaggggcc ctttccaaga 84421 ccctttccag aaggtgtggc tgagatggga accgtggact ctgtgcagat gtaggagctg 84481 gctccagtca agtgctagga ggttgtgggt cctgggaagg aagaggctct ggagcctctg 84541 tggagactct gggactgtcc ttgggggaga cgtgagcagg aagaagcagg gccttcacag 84601 tccccagctt aggggcctca ccacccagac tgaagaccag gaccaaaccc tttcctgcac 84661 agttacaatg tgtcatttaa ttttactaaa gggaatattt tttaaatgag gatgctactt 84721 tgtgtattaa tttttacctc tattcataaa agaaacgttt cttatctatt taagatgatt 84781 catatcagac cagtgtctgc ccaactcgac tgaccctgtg aaaactgggc acttcacact 84841 ccaatgatga tggatgagtc cccagcagca tagtttaagg gagtgagtgg gcagtgtggc 84901 ctcctgtgca cgtgacttcc tccttcagtg tgcccacatg tgggttccac ggtcttgtga 84961 cattgtggct ttagaaattt ctgtttccat tttctatcat tcagagtaaa tgaaatttgc 85021 aggaaattca gaaccttcca cctgtacagt ggatactgtg agactctgc cagatgccct 85081 cttcaagcca atgcatctct ccatgctccc actcccatag atgggaacag aggtgctgga 85141 actcagatct actccccttt ctgggaacig gagctgcctg cccaggcaat gcccccttcc 85201 cagggatggc tgagccaatg actggctaat gttggattgc agaggcctag cgccctcccc 85261 tcaattccta attccttgta ggaataactg aggcctcctc tgtgaccacg tgggcagctt 85321 ctccctctgc ctggtcctgt cttgttctct cctttccaat tgtgtctcct ggaagccctc 85381 cccacaagtc tgctgcatac aactctcctt ctcagagagc ctgagccctg gattcccagg 85441 aatccagcct aaaatagtct ggcatttggt ttcaattttc tctttcacta agactcagtc 85501 acaggtgcta ataaataata aaatgtcacc accttgaatt ctatcactct ctcttttctt 85561 gccccatctc tgacaagtag gtggtccctc aagaacctga aaagcagaca ttaggaggaa 85621 aggaggagtg ggggcaagag gcccacaccc cacctggccg gctcccatcc atgcgccctt 85681 gactgaggta acacctaccc tgggaatcct tcccctgcct ctcgtgagcc aggccgggtg WO 00/09525 PCT/US99/17712 EPI-109 1159 85741 ctcttgggac agcrcccac- gctcctgtgt gctcccccag cttggcacat gactccctga 85801 attatagtca gttccgtacc tgaatctccc tctagaaugc cagtgccacg aggacagagg 85861 acggttccac tttgttcact attttctccc cagggtctgg caaagttcct gggacttggg 85921 agaggtgtcc ttcaggagct tggcagaagc caaacggcac acttaagtag ggcaactgag 85981 gtgagtttaa tgaaggattc tatacaaaaa tttggacaag gtatagggag gccacaatac 86041 acagtgcagt gcctggtgcc agtgagagca gggcactatt cccactgcaa ggccagacag 86101 ggcaagggga gggagctgcc tgacaaqagc tgcccttacg tcaagggaca catcagccca 86161 ctagacccca tcaggaggga gccagggcct gactcccctg accttgctct ccaatcttct 86221 gcctaaaatt ccccatcagc caaacacaac tgaaaactga aagacagggg agcctgctgt 86281 taataaggtg agcttccccc agaataaagc tgggtagaga gtggagaatg gatatggaag 86341 ggcaaaagga agatttataa gacagtgggc actaaatatc tatgagatga ataaaggaac 86401 cacattttac aacaaacggt cattgaaacg ctactcaatg gaaagagatc atttcggtca 86461 ctgtctggtg cagacaaatc aaagcccaca tgcatcaaaa aggccatqtc cgtgtaactc 86521 cgacacgggg cagacagcaa ggctgaagcc tatggggtat gtggagccgg aactgagaga 86581 tcctgatgta aatctagcac ttgggaaaag ggggactaga agaaattcac ccacaggcag 86641 aggaaaacac aaacacttat ctatttttgc ctaggcttta agtggtatgg gaaaaatctc 86701 tgagactaca aatcctgtgc ttcatgcaca ggtttataat accctcaaaa tggaagaccc 86761 caaaaccagg cgcggaaaat tcatatcagg ccattgatgc cctcaatgtt cccggctgaa 86821 acaaactcaa aactcctctg gaaaggagtg ctcccacttc aagccatgaa aagctactgc 86881 agagaaaata atccccagtc aagacacact cacattgaaa ctgcaaggca cacaaggaaa 86941 tggatcacct tgagtgatag ctggcagagc taataaacct ctgtatacct ctaagaagct 87001 ccacgcacta gtataaccct taaagatttg atgaaatcat tactttatta aaattgtttt 87061 tataaaaaat caaaatccaa aaaaagcaac aaattttata ccagagccaa ttcggtatat 87121 acaagggtgt cttactcttt tggaatttgt cttattgtcc taactcagca cattgtcctg 87181 gtctatgaaa agtcctagaa acccttctac cctctgtaat gtaggagctt taactcaata 87241 gggtttttta aattcttttt tcttgtcttt ttttcttttt taattttttc cattttttca 87301 agtcaaactg aagaaatatt tttcttttct ttctaggaat gcatattcac cccccaaggc 87361 cacttgtctc ctgattggag agtattagac aattctcagg atttctttat tttccttctt 87421 tattccatag gattgggaaa cccagtagga ttgggtttag gcatatctct aaagcaccat 87481 gtttcaacgt tttgatgtaa gattgtgccc tatttcttgt tcagttgctg ccagcagatg 87541 ttatagtttt aaaactagtt tttggtcatt gagatattag aggagggaag agtctgctat 87601 cctgctttac tcatcttcat ctacactaca ctgtcatctt cactgcaaag tcctgtatta 87661 atgtttttag attctataac attttaacag gtgtcaaaaa atcttaagca ccacttcagc 87721 ttgggaatct ctaaatgtaa tggtgtttgt gggctggact gatgtctgcg tcttgttgtt 87781 gttattgtct gtagtaatgg agagccggga gatcctggac acttcctgtt catgggcact 87841 tgatgcatta gctgccccag cagctgatta catttaaaca aggatgtgtg ggtgaaccca 87901 gggagaccaa tctcagtgga atggtggggg cagaagccag gctgcagggt gtagagtagg 87961 gaatgagcag tgatgaagta gaaacagagt ttggacaact agtgaaactg cctggaagag 88021 ggggagaaga gacagtaaat ggtctgacca atgtttgagg tcaaagtggg tttgtaatct 88081 ttatttaagg gacagatctg agcatttaaa aattctgaat aatctaatag agaggaaaaa 88141 gttgggactc aaagaaaatg tgggaaaaaa tgatgaaggt taaacggaat gagatccaga 88201 gtgcaggggg agagattagc ctttggtgtt agaggagcaa ctctgtccat ggagagagga 88261 aaaatgtaga cataccacag ttgcatttga agttggggcc tgaggagttg aggagttctg 88321 agaaaagcag aagatgagat catttcctga gagtaaatgq gagtcattag aacgggggtg 88381 aagagactgg aagctttagg tagcttgaaa tagttgatgg aaaaattgga taaagtgaca 88441 atttgtcaca ctcagaacag ctatcaggga atctagaaga atctctggaa gctagttgaa 88501 gatcttaaat taccaatgta tcttgtccac atagctaagc ggttttactt atttttattt 88561 ttttgaaaca gggtctcact ctgtcacaca ggctggagtg tagtagtagt agcacaatca 88621 cagctcaatg caatctctgc ctcccgggct caagcaatcc tcccacccca gcctcccggg 88681 cctgggacta cagacacaca ccaccactcc cagctatatt ttgtacattt gtagagacag 88741 ggtctcgcca tgttgcccaa gctggtcttg aactcctggg ctcaagtaat ctgcccacct 88801 cggcctccca aagtgctggg attacaagct tgagcccggc tgctaagtgg ttttaaacag 88861 ctgttctcgg aaacacacac tcaaagaaaa aatgtagagg ataatttatc taaggctggg 88921 gcttcaagag aggtcagggt gttgacaaga gaatgactaa gtggcagact actggatctc 88981 agctagataa agagggatgt gatcgtggga ggggctgata gtcagaggct ggaaggcttg 89041 atgaacaaca catattacac aaagaataaa tggagtgaga gaaaccaaag gagtaaaagt 89101 tgtcatcaga aaagtgagaa attttattgt gagaattcag tggtaaatCa atgttaacaa 89161 acctcagctg ggcactagtg gagtgaaacc gaaggccagg gagttgagtt aatgagctga 89221 gacttgggca ccagatgggg gtccacatgg acaactaagc caccaggatg atgtgggaaa 89281 ctggggtgaa tagaagcccc ttatccatgt gcacaagtct tgaataaaat aggggcaacc 89341 aggcagtcag tggatgatag cagtgaggtg gagcagagag caatgtagtt ggagaagtgg 89401 agcccacagc agtctccttt atatctagaa gggaattaat agccaaaaaa tggcaccgag 89461 gccaaggatg tcaccttctg actcccaaat ctgagacaga tgtgagaggg aaggagtatc 89521 ctcaagggac aggagatggt gcgaatgttt ttggcataaa tcaaagatgt cagggaaatt 89581 gtcagaattc aggttccaga gacacagagg aaaagcgtgg gagaaagtgg aatattggga 89641 ggtgagatta gggcagagga agcacaaatc aaagaacgag gaatagaaaa agtcatatga 89701 gctgaggagt tggccaaaca tgacagaatg ggaatatgat ggaattaagt ggctttatgt 89761 gttccaaaag gattggtcca cgcaggccac aggaaaatgg gaggtaagaa gaaagggatc 89821 gaaatgctgc aaagtgtatt acttcatggt aagcaaagga ctcaagactc tagaaaatga 89881 tgcccttcct tccaagacta tgttagtcca aatctttcaa gatacagaac ccaaggtggg 89941 gtctggcata caagaagtat aatagaggaa atgtctgtga catttgcagg actgcaaagg 90001 gagccaggag aagctgggaa agccatgaga tcacaagcag gtctgactcc aagtgaagga 90061 gatggggaat gacgcaaggt ttggctgaag catgtgccaa aggcacccat cagaggagtc 90121 cctctccaag ggatgggcct atcatagtgt ccctaatagt gtcatggagt gggagcagcc 90181 cacggagggc acagccttgg catgaacgca gacatgggtc tcagagtgca gcagctgggc WO 00/09525 PCT/US99/17712 EPI-109 1160 90241 ccctcaazca attaggctcc ctcagagctg gggcaggagg tgcaczagac cacacagtaa 90301 tattta::ta ttattaattt aattaataat attaatttat taatZ:-=att aataatatat 90361 ttatttattt attattacta gaccacacag tagtatttgt atgtctaagg aagcatttct 90421 cagaatarac tcactgaact tttagcctat aagtacctgt atgaaaattt taaaaggggt 90481 ttcatgacca aaacattttg ggaaacactc catacccttt cttCttcatg aaggatcata 90541 acgcctatta gtatatgaag ggctctgaga agtcctgtag taaagaaact tgctttagtt 90601 ttttagtcca gcaatttttc aaacttaaat gagcaatagc ctcccazcct tttttttaca 90661 ctttttagca tactgcggaa taaactcaac atgcattgag aaagactgct ttagggaata 90721 gtcaacacta ttcactccc agtaagtaca tataaaatct gtatttccag ggtggattat 90781 caacacagct gtattttaga aatattatct gccctcccag gtatcacagc tactaattat 90841 tgggtactga ggtggaattt tagggatcag ccaattatgg gaaagaaaat ctgggggcag 90901 gataagatgg tctccgaagc cttaaaatta tatgccatta tttacctctt tgatctacta 90961 ctcaatatca aacaactaat tcagaagaaa attgattgtt ttctaaaagt agtttttcta 91021 catttcccat taagaagcag tggtatttaa aacttataat ggctattatg tgagattatc 91081 actatcatag tttttctcta tacaaatttt ctgtaacatt ttatttgcta ataaaaatta 91141 gatagatgga ttgactaatt gataatctaa gaaagattat atttgaagaa gccatagtaa 91201 gggacagatt aaattatcat cagtctaaac attctaatac ctatttctct ttttttgaaa 91261 ttttccaaat ttgttattat gcatttaaac aataattttt tgaactttta ttttaggttc 91321 tggggtacat gtgaaagctt gttacatagg taaccttttg tcatgagggt ttgttgtaca 91381 aattatttca tcactcagct atcaagccca gtactcaata ggtatctttt ctgctcctct 91441 ccctcctccc accctccagt ctcaagtaga cctcggtgtc tgttgttccc ttctttgagt 91501 tcatgtgttc tcatcattta gctcccactt ataagtgaga atacaaggta tttggttttc 91561 tgttcctgtg ttagtttgct aagggtaata gcctccagct ccattcgtgt ttccacaaaa 91621 aaacatgatc tcgttctttt catggctgca tagtattcca tggtgtatat gtaccacact 91681 ttctttatct aatctgtcat tgatgggcat ttaggtttat tccatgtctt tgctactgtg 91741 aatagtgctg caatgaacat tcacatgcgt gtgtcttcat ggtagaatga tttatattcc 91801 tctgggtgta tacccagtaa tgggatttct gtttttagct ctttgatcta atacctattt 91861 ctcaagatca agttagatct ctaaaaaagg catcatccta gcatttcccc atcccttccc 91921 tgaactaaat ttaatgttgt gtgtatcaat cagcatacag tcaagacaga aaccacacat 91981 gaacattaaa tataatgagt tattaactta taaaagggta tgaactacta aagggggtaa 92041 ggagaatgct gaagaatgca ggaatggcag atgtagagag cagccataac ctctaagcta 92101 aggcacagca gccaaggaag gggcgaactc aaaaaatgcc ctccctcccc agctgatcca 92161 cccttgttgg agggggtgtg gctgcaaccc aatggatgcc caagaagttt gcagagttgt 92221 ggcaggttgg ggctgctgag caggaaactg cccgaagggg taccagtgag attcccaaga 92281 atgtgggcat gcctctggcg aggaagacgc tcttggagtg ccagcaaaat ttactaggaa 92341 gctacccagt agggtgccag caaaagtcag caggaagcca ctgtcgtggt gtcggcaaaa 92401 ttcactgagg agtgggcact gcagggtctc cacccagcac tggcaaatca gccaaaagaa 92461 caaaaacaaa ataaaaacaa atcccagaac cagaaagaaa aaactctgcc tcttactgcg 92521 accctcttat gccttctaca gcaactggca aaggagaaat gtttatgggg tccagctcta 92581 gactcacaaa gcagaacaca gaagagtgaa tgaagagctg aaaggcgata aatcagtaac 92641 tggagcctca catcctttgc cttttttatt gagggtcaat atattaagaa gaatatgtct 92701 gcgtcttcgg taaaattatt gctaaggtta tcacccagtg tgtgttttca acctccctga 92761 tataagaact tagtgacaag aaagaatgag acaatgatca tgaactattg gacccaacca 92821 tttgtggctt tagtgcccat cttctcagca aggctttctc tctctctctc tctctctctc 92881 tctctctctc tttttttttt tttttttttt ttttaagatg gagtctcact ctgtcaccca 92941 ggccggagtg cagtggcaca atcttggctc acggcaacct ccacctcctg ggttcgagtg 93001 attctcctgc ttcagcctcc cgagtagctg ggattacggg cacccatcgc cacccctcct 93061 ggctaatttt tgtattttta gtagagatga agttttgcca tgtcggccag gctgttctca 93121 aactcctgac ctcaagtgat ccacccacct cagcctccca aagtgctggg attacaggca 93181 tgagccacca cagccagctc tcagcaaggc tttttctgac tacactattt aaaatgtgat 93241 ccctgagcca ccttggcctc tcttgctgtc cttccctgct tcgccttctc catagcactt 93301 ctctcctact aatctacaat ttacttgagc tctgtgaagg tcaggatttt tgcctatttt 93361 gtccattggt gcatccccag cacctggaac agagctaggc acaggctagg cactctagaa 93421 atacttgctg aataattgaa ttaagtaaat gagtgatcta cacgtagtgg ggaatgagag 93481 tatacagtga tagttccttc gactaaaact ggggtcaaat tatagtgata aagaggaact 93541 cagaccttca gaggtaagct ttgtggacca cttgccaagg ctgcagaatg tgatgtcgtt 93601 tcacaaacaa ggaggcccta ttatggcttc agatatgaga ataataaaga gaactttcct 93661 ttcgcctcaa ctgcagcctt ctaaactctt ccttccttcc tatgtagaag tttcaaggac 93721 ctcatggcct gagtgtggat aggcagaatg ctgggaatca ggcaaaaata aaataatact 93781 gaaagtgaag gtcatgctaa tattagtaag ccagggtgat cctgaattta caaaacattt 93841 ttctttggga aatttcacac ctcacatgat tctgtgtttt tacttgggaa atttcacatc 93901 tcacatgact ctgtgacatg cggtacatga ggtgcctgac tgctgttttt gtcctctact 93961 aatgaggaag agtgtgcgta ctcccagcgt tttgcaagtt tcaaagtctg acttgacttt 94021 ccttcctttt cctggaactg atccatgagt atcgagagta aagctgcccg cacctactca 94081 ttcaagatcc tgagtgtcct gcccagctgc aggaggtgga gagacccagg aggaggggcc 94141 actgctgatc ccaggctgta gggggtggga agagtgtccc agggcaccat gacccccact 94201 cactcactca caggagaccc acacaagaga ggagagggca cttacagctt aggttcccac 94261 cagcaccaac tcctctgcca tcaaacatca ttgtgtttct ctttctgcct tgtctgtcgg 94321 cacacgtgga gttaaattta atgctcaatc acatatttgt ctgggctctt tctgtgttta 94381 tttttctctt aatagttctc tctcctccct tcctctcccc gcccctcctc ctccttcttc 94441 tttttttttt ccagagacag tgtctcgctc tgccacccag gccagagtgc agagtggcat 94501 gatcatggct caccgcagcc tccaactcct gggctcacgt gaacatccca ccttggcctc 94561 tggaatatct gggattacag gcacttgcca ctgcatctgg ctaattttta tattgtttat 94621 agatccggga tctcactatg ttgcccaggc tggcctcaaa ctcctgggct caagcgaccc 94681 tcccacctca tacttctgag tagctggggc tgtaggaatg cgcctcagtg ccaggctagt WO 00/09525 PCT/US99/17712 EPI-109 1161 94741 ttcttaattt tctatttcta ttttgacag zacaaatttt gtatzaatc ctacctcaga 94801 cacatctttg gtgggaaaag gatgtcartt aatcaatata taaatzctaa gcaaataagt 94861 ctgatcccca aattaggtta gtcacagczq ctgagtcgtt gacccaagag aagctcatct 94921 aqattttttc attattttca agttcctctt ctcggttcgt ccttcttcca gaccatgccc 94981 tccccgtccc actctcttcc cacagcctcc cctccccaca gcctcctccc accattccaa 95041 atctgggctg ttctctcaac ttccttctcz ctggactcaa acctacccta gcccccagcc 95101 tcagtttggg gttaaacttg tcctcctcac attctctccc acccaacctg atgtcgcctc 95161 tgtgtcatca ccacgggatt ttcctcctct gggttctcct tttccuagtg gggtcagctc 95221 ccccatgagt cacagcacca atcacttcta gctqCttgCa aacccczttg ctttcctcag 95281 tgttgacacc cagggcagcc ctatgctcac tgccgctgag accccacctc tgcccctggc 95341 cttttcccag ctgacarcac cctgtggctt ccattttcct aaaat:ctct tttgaggcct 95401 cagtcttaac caaagcacac agtgcccctc aaaaatgaca ataaaaaccc aaacacaccg 95461 tgactgtcat ggcaggttcc tggtccccgt attgaatcag cgggtgggtt tctgcgaaca 95521 ctggtgagag gccgcattag agggtcagga ccctcaggtc tggactcgtg gtcaccacat 95581 accttcctcc ctgctgacag tagctggtac ctgttaccta ctcagagtgt cacatgccac 95641 aagccagagc gtcttggcag ttctcagcac cttgacatca cttccztgct accactcaga 95701 gcggcagtga cacagttccc ttatctcaga aggccagaag acggczatca aaggtcacag 95761 ggaaatcaaa ggcggggtac agggccagag ggaggaggaa acaacztccc ggttgctttc 95821 agacgcttca gagatcctct ggaggcctgg gggagctttt gagtacttta tttcagttgg 95881 tccctgagct cggtgagtgg ggcgggtaga gccaccaggg gaatcaacag tggtttctcg 95941 tgcccctcag ggtcaggagc agtctgacca aaaggagggc atccactgtc cggggccatt 96001 cccacagctc ccggatgctg ggtctggagg ctgcgccctt cccctgcagg agctcagccc 96061 agtggtaagt catctgtgtg tcatctatgt atttaacccc ttatggccat gttgatgctg 96121 agcatggttt cacttttgca aacatttatt tatacccttc gagagaaaaa cgtctcagct 96181 gtcacaggaa gctgcttcgg ggggtgagca aactttttaa aatgcagaaa ttatgatcta 96241 cacccgtttc ttaaaagtaa gccatcgtac ttggttctct ttaattatat attttcttac 96301 atattgtqtt catgtaggca agtcctgttt ctgctaaaag aaggtaagtt ctaccaaggc 96361 ggtgtcatgc cagctttatt tcccgtggca cctggcacac tgctaagcac ttacatgctt 96421 aacaactaga ttgggaatgg tgctgctctg gggaagtggg cacacgttaa agaaatgttt 96481 atttcagtct tctgaaatag ggaattactc tggctaaaat gtagctccag aaagggaaag 96541 tggggctgta tgaatccagg tccagtttgt tgtttcctcc aggataaggc agctgtcgga 96601 ggggaaaatc atctcccatt tctccacagg gcagtctgaa gatggccaat tacacgctgg 96661 caccagagga tgaatatgat gtcctcatag aaggtgaact ggagagcgat gaggcagagc 96721 aatgtgacaa gtatgacgcc caggcactct cagcccagct ggtgccatca ctctgctctg 96781 ctgtgtttgt gatcggtgtc ctggacaatc tcctggttgt gcttatcctg gtaaaatata 96841 aaggactcaa acgcgtggaa aatatctatc ttctaaactt ggcagtttct aacttgtgtt 96901 tcttgcttac cctgcccttc tgggctcatg ctgggggcga tcccatgtgt aaaattctca 96961 ttggactgta cttcgtgggc ctgtacagtg agacattttt caattgcctt ctgactgtgc 97021 aaaggtacct agtgtttttg cacaagggca actttttctc agccaggagg agggtgccct 97081 gtggcatcat tacaagtgtc ctggcatggg taacagccat tctggccact ttgcctgaat 97141 acgtggttta taaacctcag atggaagacc agaaatacaa gtgtgcattt agcagaactc 97201 ccttcctgcc agctgatgag acattctgga agcattttct gactttaaaa atgaacattt 97261 cggttcttgt cctcccccta tttattttta catttctcta tgtgcaaatg agaaaaacac 97321 taaggttcag ggagcagagg tatagccttt tcaagcttgt ttttgccata atggtagtct 97381 tccttctgat gtgggcgccc tacaatattg catttttcct gtccactttc aaagaacact 97441 tctccctgag tgactgcaag agcagctaca atctggacaa aagtgttcac atcactaaac 97501 tcatcgccac cacccactgc tgcatcaacc ctctcctgta tgcgtttctt gatgggacat 97561 ttagcaaata cctctgccgc tgtttccatc tgcgtagtaa caccccactt caacccaggg 97621 ggcagtctgc acaaggcaca tcgagggaag aacctgacca ttccaccgaa gtgtaaacta 97681 gcatccacca aatgcaagaa gaataaacat ggattttcat ctttctgcat tatttcatgt 97741 aaattttcta cacatttgta tacaaaatcg gatacaggaa gaaaagggag aggtgagcta 97801 acatttgcta agcactgaat ttgtctcagg caccgtgcaa ggctctttac aaacgtgagc 97861 tccttcgcct cctaccactt gtccatagtg tggataggac tagtctcatt tctctgagaa 97921 gaaaactaag gcgcggaaat ttgtctaaga tcacataact aggaagtggc agaactgatt 97981 ctccagccct ggtagcattt gctcagagcc tacgcttggt ccagaacatc aaactccaaa 98041 ccctggggac aaacgacatg aaataaatgt attttaaaac atctatttaa tgtattttaa 98101 aataatttgt aagttgattt taaaaccaat ttaactacat tccaaattat agacagccca 98161 tttatatggg agtaactttt caggctcatt gcctcgccgg tgatgagaag aactagctag 98221 ctggaagctg tgggaaaaag aggtaaggta acttgttctg tcgaagttct ctaaattctc 98281 ttgcttactt gccacacccc taggccccca gcttccccta acccaaggtt tctggtattt 98341 tctcgtactt tatcaagact atggaatctt aggagactta acaaaaccaa atgagaaatt 98401 atgtttagaa atgtctaaca aaatgaattc tttgtccttt taagtataac acatacctca 98461 ggcctcacca gcacataact acaaaaggtt gtcccacttc ctttctgtgg ctgagttagt 98521 agaacacagg ctcccacctg ccacatcagc agaaggtcac ctcaacatgt gagctacctc 98581 cccggagacc ccccagatcc gtaaggatga tgcatccttg atcctaaaaa cattttcctg 98641 ttcctggtgt tcagaattgg actccacact cactggtctc tttataatct tgcttctggc 98701 cctttgaggc ctcaaagcta ccagggcctt gctgccaggg gacaatcacc gctcccggct 98761 gagtcctgca gacatagggc ctgggctggc tgcctcctcc tgctggccca gcatcttgct 98821 tgcactaaag agagctggag gcttggcact gatgcttgct aaaaacctac ccaggccgcc 98881 cactgctgcc gcactgcagg gcaccagccc acactcctcc cctcctggca tcaggcacac 98941 gttcacggca ctaaacctta caggaaagca gtggaaccct gtcttcctt cacaggaggc 99001 actttccttc ctaggcaaaa acgatgatac ccatgggcac agcatctcac atagggacac 99061 aagagatgt ctgactcatt aaaacccaag ctctggcca attaaaaggg gtccttaatg 99121 tcctactcaa cagtggtgga aggaaatttg ctctatattg atgaaatag gtggagaaaa 99181 tctgattttc caaacatgag aattctccat atgccaccc ataaccaaag accccttatt WO 00/09525 PCT/US99/17712 EPI-109 1162 99241 tgcgttagat gaaaca:: a aagagcozat taagatagcg gatgagaccc ccaagggaca 99301 tgcttataca acaataaczg gctccaaacc acactccatg gcagtggctc tcaaatgcca 99361 gctcacatca caagccczzt gctaaaacac agagttctgg gccccatccc ggagtttgtg 99421 gttcaggagg tctagagtgt gacctcagaa tatgcattc taacaaattc cccaggggat 99481 gcagatactg ctgacccaag gccctccttc tgagaaccac tgttccaggg agaagaaact 99541 cagctaagta agggtttaac tttgtgctga agacaatgtg gaatttagag ttggggtgaa 99601 ttattcagga aagtaaagag gtttggagat gtgagggtgg gaagcgcagt ggagggaggc 99661 agagaggaaa tatgaagcau cgtcagttgg agagaaatta ggaagaggaa taaaatgata 99721 tatgccaggg atttcagttt tgctgagccc atgatgacag actcttctct ggcaccttat 99781 gccactcatt gagggcttat agctggctct gctctttcag agtcataata gggctatggg 99841 tctgacctca aggtgagctg gaatgggcac aagtaataga taaaactgca agaagtcact 99901 caagggtcct tcctagaaca aaggatccct acattccaaa ggcgaatgcc ggtcactatc 99961 ataaaagaaa agaaagaaag aaactgatgg tgacatttta aatggCaatt tttctagctt 100021 ctaaaaggtt gtggagcaac tggaactttc ataccctgct ggtgggaatg taaaatggta 100081 taatcacttt ggaaaaattg gcagtgtcac caaaagcaaa gcctatacct actatccatt 100141 tcactcctca gtatttaccc aagagaaatg agcatgtatg tccatacaaa gatttggacc 100201 caaatgttca tgacagcctt atttatatag cctcaaacta gaaaaagtct gtctatcaac 100261 aggtgaatgg ataaacaaat actggcctgt gtatctaatg gaatactgct catccacaaa 100321 aagaaacgag ctattgatac acacaggagc atgcacgaaa tctcaaaatg ctgaatgaag 100381 gaggccagat tttaatttta tttttaatta tttatttatt tatttatttt tgagacagag 100441 tctcgctctg tcacccagcc tggaatgcaa tggtgtgatc ttggctgact gcaacctctg 100501 cctcctgagt tcaagcaatt ctcatgcctc agcctcccaa gtagctgtga ctacagtcat 100561 gcacaagagc aactgactaa tttttgtaat tttagtagag acggggtttt gccatgttgg 100621 ccagctgctc tcacactcct gacctcaggt gatccacctg cctcggcctc ctaaagtgct 100681 gggattacag gcatgagtca ccgtgcccag ccggaagcca gatatttttt aaaagtactt 100741 attttgtgat tctatttata taaaattcta gaaaatgcaa acaaatccat agcgacagca 100801 aatcagtggt tgctggagat gttggagggg agaggagagg aatagattgc aaaggggaac 100861 aaggaaattc ggggggacag tggatatgtc tgctattttg actgtggtga tggtttcatt 100921 ggtatataca tatgtcaaaa acgtaacaag ttgtatacgt gatttattat gtgttgacta 100981 tacctcaaaa aggctatttt ttaaaatccc cctcaggctc caggcactcc attacgttgg 101041 tgtgacttgt cttggaaata tactttgagc atttgccgga ggagatccag tgcctgggcc 101101 tctgtttctt ctcccaagta gaattggcag ctaaaacggg atgcccatgg gcacaacttg 101161 tcacccccat caccgaacag ggagcagaag gaggctgctg ggggtgcccc cacagggagc 101221 acagtctcat cgggaatgac ctgccatggc aaataaaatc accagggcaa gtcaagggag 101281 agaccaggga agagagtgat ccagtctata ttaaaaaagg atgagaaagg ttgaagaaaa 101341 agagaagaag ggacagaaat tctcttcaca catttgcaga agtaggtccg gactctccat 101401 ccacttctcc tcctccgata ggtaggacag gaatctcaga ggaaatggca tcatcttccc 101461 atgtttacag acacagcaat gaactcaaag aacaatctta tcaggatttt ccaaatgaaa 101521 acatggagca tatagagaat aaagatccat aaactcgtat ggtggctgag actgaaatgg 101581 ttaatgaaaa gcaaaagtgt gtgctgaatg acaccagcca caatggcctg aacacttaag 101641 tagtgtaata tacttggaac attgacagct aacaaggtct tcctcccatg tcagaccaag 101701 aacacagttt cctaaagata aaaatagcac atgcttttcc acttttccat aagtgactgc 101761 attagaaaac taacaaacca tgaaaagcaa aatatggcta gtctcttcaa gaaaaactgg 101821 tgtttctatt ttgtctgtaa attactttct aatacaaaaa acaattcctg ttacattgag 101881 gtaattctaa ctagggacat atgagagaga gattgaaatc tcatgagctg tctccttttc 101941 atctcaattc tgtgtactcg tgggtacaaa tggaactagt ttttgtttgt ttgtttgttt 102001 tttgagatgg agtcttgcgc tgttgcccag gctggagtgc aaaggtgtga tctcggctca 102061 ctgcaacctc tgcctcctgg gttcaagcaa ttctcctgcc tcagcctcct gaatagctga 102121 gattacaggc gcctgccacc atgcctgact aatttttttt ttgtttgtat tttttagtag 102181 agacagggtt tcaccatgtt ggtcaggctg gtctcaaact cctgacctca ggtgatccac 102241 ccacctcggc ctcccaaagt gctgggatta caggcgtgag ccactgcacc tggcccggaa 102301 ctagttttaa aacaggaaac agttgatata ctgaatggaa aaacaataca atttgaagtt 102361 gaaaaaacaa aataagatgc ccagttaaat ttaaatttca gttaagcagc taatagttat 102421 ttagtataag tacaacccat atacgacaat tgcagtattt qttatttatc tgaaattcag 102481 acttacctgg gcatcctagt atcctgtttt ttgttttgtt ttgtttttcc ctttgttttc 102541 ttttttttcc ccgaaatctg accaccttaa ctttaaggta tttattcatt tttaaaaact 102601 aaatattttt cggcagtcag aactagagca aagataaatg atcccaggac tctgtttagc 102661 aggcagtcag gaagtgtgac agtgtggtgg gtggcagccc cggccaggcc tttcctcttc 102721 cctaaactgc cacagcagga ctgccacact tgggaatccc agtttCcatc tgagcagccc 102781 ctccagagtt tggaaggagt cagtgcttta gcctgaggag ccgtggatgg ctctaacact 102841 ttgcttgtcg gttgaataaa aatcaaccca aaggtggcct acactcattg aagtaggaat 102901 gccagaactt cagtggtgtc acatagaaga aaatatctaa gtgcttaggg agatggcagt 102961 gctagtggat ctactggatc attaagactc actcacccac ccagcgcagg tctagaggac 103021 acacccttgc cacactggga agtgtaaatg agctccagca tctttatttt tttttatttt 103081 ttatttgttt tattatactt taagttttag ggtacacgtg cacaaagtgc aggtttgtta 103141 catatgtata catgtgccat gttggtgtgc tgcacccatt aactcgtcat ttaacattag 103201 gtatatctcc taatgctatc cctccccccg cccccggtgt gtgatgtccc ccttcctgtg 103261 tccatgtgtt cttattgttc aattcccacc tatgagtgag aacatggggt gtttggtttt 103321 ttgtccttgt gatagtttgc tgagaatgat ggtttccagc ttcatccatg tcccgcatct 103381 ttaaaaaaaa aaaaaaatct ctaagtggtg gctcttctct gtagatcagg agctgtagtg 103441 agcaatgcta caaaactgga gtttctaaat acagggggga tggtgggatt ctgaggaagg 103501 acaggccacg tggtaacact tacaaaagac caagtgggtg tggttgccac tgtggacggt 103561 ggagccaaag cagtcctcag aatagtctga cccccagagg tctttggcat tggctggttg 103621 atcatggtgt ccctggaatt gaaatagaag gacggtctac taaattttta cctgatctgt 103681 ataagcagaa agttctatc tctagtgaac agaagtctaa ctttagtcac cagaactgag WO 00/09525 PCT/US99/17712 EPI-109 1163 103741 agtcaattca atcaattcc agatttgaca tagtttatag acctaaaacc ccttgaatga 103801 aaggtaagct ggctccctt gaggaaggac cctgttacac ttzcggcatt ttattctgat 103861 aatctttttt cccagcc cccaaagcaa cttagggcca tttaccaggg aaagccatg 103921 aggaaaagga aataattagg ctatttggag attccaagac actggczcta cgctgacacc 103981 agttctaaga gacccaaaat atctttgtgg tctaccagcc aaagtagggc ttcatagagg 104041 tcaggggtca ctagagtttg agctcaggtc tgtttcactg tgagtctaga gggtccctga 104101 acttatccta tagttattcc cccagttcca gaatgcagaa ttgagctgag agcagtggct 104161 catgcttgta gtcccaacac tctgggaggc gaaggtgaga ggatcacttg agccaagcgg 104221 tttgagacca gcctgggaaa tatagtgaga ccccatcttt taaaaagaca aagaaaaata 104281 aagaaaatta acatggaaaa ataatataaa atgtgaataa tctcacatct actaaagaaa 104341 ttcaatctgt aattagaact cctcccacag agaactataa gcccagtgcc cccatcaact 104401 ggagaaacag aaagaaacaa tcttcttaac agaaagcata attggaatag agatactctg 104461 catcggggaa gaatccccat attgattctc tgatccatag agtgaaggcc aagtggaagc 104521 ctttggaact ccctctacct gccaagatac taaacaaaac aacactgcac gtctggagga 104581 attgtagcaa gaacttgaaa gatgaaggat gatgatgtcc acctctztcc attcagctca 104641 cctatctggt ttgtgcagaa gacaaatagg tgttggaaaa tgacagtgga ccagtgtaaa 104701 cttaatcagg cgggggctcc agctgcagct gcagqatcag gtgttgtttc atttctgcag 104761 ctaatcaacc cttctcctgg cacctggtgt gcagatggca atttttcttt tctattatct 104821 gttagtaaag actatcagaa gctgtttatt ttcagttggc aaggtcagca atacactcca 104881 agggaagagc agtctgtctc agatcttacc gatgcctggg gatagggagg gagtggcccc 104941 ctcaccgtct ccaaggccta gtcctctgct cctgctactg gcagcaaatc cacgcaggtc 105001 tgcaacaacc tcaattcctg cctcctcaga agaaagaatt caattgaggg acgtaagaca 105061 gaaggagaga ctgaggcaag ttttagcaca ggagtaaaag tttatttaaa agctttagaa 105121 taggaacaaa aggaaggaaa gtacacttgg aagagggcca agtggacgac ttaaaaagca 105181 agtgcgtggt ttgacctttt gacttggggt tttatacgtc agcatgcttt cggggtcttg 105241 cgttatttct cccctggttc ttcccttggg gtgggctgtc ccatgtgcct gcetgagccc 105301 actggctcaa ctcctgagat cttataggga aactactgct caccagtttc gagtgttttc 105361 tatctattag gagccggctt ttccctgttg ccgggtgtga ccaattatta ctttagaaag 105421 acagtcaaca accgccagac catcacctga tggtcacctg acactcctgg tgtgtggggt 105481 atggggagcc ctctcctgcc ctgctctttc tgactagcta cccactataa cactcccaga 105541 gggacctgca cattttgtgc tctttgcaag acagtgcctg cccagcacct gtaggcctgc 105601 tcaccccttc agggtcatga tttttgcttt ttaccgcagg tacccataag caaaacatgg 105661 cattgttcac catgctttta cattattcac ataattttaa gttatttaca caacaatgta 105721 aaaccatggt gaaccatgcc acatgttgct tatgggtacc tgtggtaaaa atcctgctac 105781 tagctcattt tgcagtgtct ataatgacag gtaatgctcc attcactcct ttatgacact 105841 tgcaaaaact gagaacataa cgcctcccag ttaagcaggc atctgggcaa tgtgaggaga 105901 acagaaatag accacgctgc atttatctct cttgatgaca ggcattgaga tttccacttt 105961 ttctggtttc ttattatgtc tctactgggc attcttacat acatcttgca cgccatggaa 106021 agtttctcta gggcagtggt tcacaaactt tttggataca gaatactttt atgtgcttga 106081 aaactgagga ccccatacag ctttagttta tgtgggtgta aggttctagc ccaaactgaa 106141 gtccgaaggg agttggtggg tgggtgaggg gtagctgaaa aaacacccga ggaatcatag 106201 gcagtttgaa catggcctta tcctctctct gggcacgagc catatgtcca gtgtcagcag 106261 ggtaattata ccttttacag acaatagagg ctctgaagca atcacgagct cacgtgagtg 106321 gtcacctaat gcacctcaag tggcatggtt cataatgtgc ggagtcgtgt gcctacgctc 106381 caaacccact gagtcatggt gcaccaaaaa gtggcctcag cctgcrcctg actaaagcgc 106441 agccatcttc cttacactcc acccctaggc caggggcatc ctccaggtag ggacatgtgc 106501 ccgtagggtg gagccctgaa tccataatcc acagcaacaa tacggagagc aacagctcat 106561 gactaggatt ccagctatgc tacttatgac tatcagggcc cagcgtaggc cagagccag 106621 ggatgtctac catctctgca gggggtcatc agtaaggctc ttgactacct taatctcctg 106681 tgagacccct tgcagggctg ctgttatgtt ctgccaattg tcagggataa aggtacaaca 106741 ttgtgttcct aaaagggcac aggtgcctcc ttaggcagca gttactatgt ctaagaccat 106801 tcggtttcgc aacaccacct ttctgatctg atcaacctca tccattaatg ggaagagggc 106861 cactcaggtg taattcagag cctgagcagc atgctctgca agagcagtaa cttggcttct 106921 acagttgtga cacacactcc agggctagtg cctgtcaagg ggtaaaacca ccagggtgct 106981 cattacactt gcaaaaaccg agagtgtagc acctcccagt tatgcaggca tctgggcaat 107041 gtgagaacag tggcaggtac atgaggccac cctcaggtat aatgtccagt ccagtttgct 107101 tataggtaag gccaccctgt gtccccacag acccataaac tcccaggggg cacacagtcc 107161 atcgaggccc cttggtgggg ccgcgtcttc caccatacct ttggtgtggt gacatgtatt 107221 atgcttacac acactgtgac gggtacccat cccacagtgc tattacccca gtgttgctat 107281 atgcaccaca gtgcctgggc caggggtact gcacgttacc tcactagcca gccccaccca 107341 tcataaatgc tatgggccag ccagggaatg gctgtgctgt gggtcttgtg gcatcctttg 107401 tccaaaactt gccacgttgc gttccaggca tcagccatgg gaccccaagt ctccagccat 107461 gtctggttct ctgcagatgc tgaatgtatg tgctaaagca agccatctgc agctgctaga 107521 agggcggtgc agatccaaca gttggaaaca ttggtcactt cagtgtaggt gtgggcccag 107581 tccacaatgc agttggagca tgttaaccta cagttggaat gacagagtag gcataggtac 107641 taacagagga aaatcacatc cctcaggtaa aatacaggct aacctttcat ccctggataa 107701 caatgcagcc cccaaggggt tctgccctgg gcaatagtac cacacctttt cagctcccca 107761 tggttccttt gggtcctgta ttcatgcgaa agtcacaggg gagcttgtag taggccacac 107821 agacagtaca tttgaaccct ggaggaaagt ttcttccctg gccgttttcc tacaaacagt 107881 taacttcggg gaccattcat tgaacaccca aagagtgaca tacaagtcat actgtaggcc 107941 ctccccacag ggagctacga tggacaacca ccagcagccg ggggcttgga ggggctatgg 108001 ccacagccag gttttctgtt cccctgcctt cagggacgtt ggggcaggca acaacaggtt 108061 actgttcatc cccatacctg gtcagaggcg gttacccttg gtgtgtatct gcaactgaat 108121 aggggtggtg gcccatgtaa caaagcctcc acctgggctg ggctgctttt ccatggccat 108181 tcattcaagg tttggagcat caggtccagc ctggaacttc agccctgcaa agacaggagt WO 00/09525 PCT/US99/17712 EPI-109 1164 108241 gtgacatgca agtaaaaccc artcttcaag agctcgctat atcaczcaat catacccaca 108301 gcttgcaagt tgrgcggtac atggaatccc tactttatgt ccattattgt gcctgttgtc 108361 cagtaaaatg tgtcccccat cactctcaat gaccaaaggg caaccatata gagcacataa 108421 gtgttgcagg gtctggatgg tgtgctgttg gttggccacc ctgcaaggat aggcaaacaa 108481 caggcctgtg gctgtgtcca cagctgttag cgcatgagta tacccttgtg acttcggcag 108541 caacccaatg taqtctactt gccacctggt caagggcact tgCCtgttg tcacttgtgt 108601 agcactggac agctgcctcc atttagggta tgcctgagca catgccgggc atttctgaca 108661 agcctcccaa atgtcttgca tgggcagaga cagaccccaa catttattga cttgttgcat 108721 cagtttaccc cctgcatgtc ccagtttccg gtgtagctac aaggccacat ctcatgtaga 108781 tgccaaccct aaccatcqga ccttggccaa ggcttctgcc tcgtcattgc tgggggtggc 108841 cagaggcata tggcctgaca aatgataaat agttacatct ttgcaatgac ccatttccca 108901 gaggtcttgc tacatgggtt ggtggcccca aatgggttgg tggccaacta gccaattctg 108961 tattttccaa gtagttaaac acaaagttag gcctccatag actgcccagc tatcggtacg 109021 gattaccata ggtgtctccg ccttgttgat caccatccat actgctttaa attcagccca 109081 ttgactactt tgtccacatc tggtttcaaa ccatatggtt ttggtactaa gttggactgc 109141 aacactggtc caagcaggag tagcacctcg actagaccca tctgtgtgcc atgccccatc 109201 aggaatagag ggatgccctt ccttaaatgg cagtggctca gggtcaaggg gtgcctcagg 109261 ccccatggcc ctctcttgca ttaggactgc aggtcccaag acCtcttgca actctgctgc 109321 taatgggctt gtgctcagcg tactctgttg ctccaagtaa gtgcctcact ttgccaaagt 109381 ggatgtctgc accatcccag tctggggggt cattacacat gaatgcaccc atcccgctgt 109441 caggtaagtc atccacactg tgactgtagc ccatcctatc acttctcaca agcctgaagg 109501 gcagcatata cagctgctag ctatttctct atcaaggaat accagagctc agctcctttc 109561 catagttggg accaaaagcc tcctggcatt ctcaggcact ctgtgtgctg ccacaggccc 109621 aaactaaaac catctgtggt cacatgcata tccagttcaa atgggcaccc cttgtcaaat 109681 acccacaggg ctcgtgcctg ctgaatagcc cacttggctg ccaggaagcc agtctcagcc 109741 acatcagccc aatcccagat tgctcccttc tttgttaact gatacaatgg ttttatcatt 109801 tgagctaaat gaggcaggaa tgtccaccaa tatcccagga ggctcacaaa agtttgcagc 109861 tgcctcaccg tggtgggcca gggatatgcc taaattttgt caatgatagc ctcttgtatg 109921 gccttcatct tacccgacca gataactccc aagaatttag caggtaatcc aggccctcgg 109981 accttggatt tgttgatggc ccaactgcat gctgccaaat gttgccacaa gaggggtgcc 110041 actgcttcta aatctgcaag agaatcagag gttaacataa tatcatcaac gtaatggaac 110101 aagtggactc cctttggaca ttttcaggct gttaaatcca tggcaacaag accatgacat 110161 atggtggagc tatgcacata gccctgcagc aacactgtga aagtccattg tcatcaaggc 110221 aaactgttcc tggctctcta gagcaaggtc aactgagaag aatgcattgg ccaagtccac 110281 cacatagtgg tactgtccta attccattgt cgagtggttc atcaaatcca tgatagatgg 110341 cacagcttcc aagccatgta aaatatccac ctccagaatg tattcaggta tgggagagac 110401 atacacagtg tataagcaag gagccaagtg gccaatgcca aggtacagag atacaggttt 110461 cactttcact gactggcctc cgtaaccttt aatatatgca gatttgccca aaaacttaac 110521 tgggttccca taaacaaggc tacaatctat gccagtatct accagcacca gcacccactg 110581 tacattggtg ggggaccagt ggattgccaa ttccacatgt ggcctctggt catctggtgt 110641 ccccccaagc cagacacctt tggccagttc cctagttgaa cagaaaaggc tctacatttc 110701 cacctggctg cagcaagtag tctctgagct gggtaggacc aggtcacaca gcaatgcctt 110761 tctccccttt gggcattttc cggaattgct gccctgcata caactgtctc cgcaaagtta 110821 ggagtatttc attgggctgc ttatcaattt tctctcagtc aaccccagcc aaaatcaaat 110881 ctatccacat ctgtgagcgt gtcactcgtt ggggccccct ttttttatgg gggagccccc 110941 tgtgggtggg gtaacttccc cttctttatg gtgtggaccc tccaatcccc ctgaaggcct 111001 tctgcttccc tgagagccgc catggcagtg gttacttcat gtatgcggtg ccctacgtat 111061 ggggtgagga cagcagctag ggagccaaag gggctcagga gcatcaaacc caacatgaga 111121 tccctcatgt gggaggtgaa acatttatca tctggccctc aggtattcag gacaaacata 111181 gcctgccgca tacccatctc ccgaatgact tacaccaaat tggcatatga ctgccattta 111241 ctcacagttt tgggcatttc accagcatta ttccacacag ttcatatggc tgcctgtagc 111301 cactcagtca gggtgtggtc tccttgcgct gccactaacc acctgctcac ttgcagccgc 111361 tgacagagag aggggtgagt catggtggag gccagcttgt ccatctcaga ggtggaatgg 111421 gagataccat ctgctccctt gttccacaga cgaagcatcc aggcaggcag gggttcccct 111481 ggacactggc aacactgctt gcctaattcc tgcaactcag ttggggtaca ggcaatatac 111541 gaaatgtgtt gcattatggt ggggagtccc tgagtccacc cttggagccc cagtggctgt 111601 tcatgatcta ccttctgtca gaccaccggg tgagcccgca acaggggttc ttcctccttg 111661 gtatgaaact gagtggggat ctccagacaa gatgatggac ccaggcctgc attcatggta 111721 gcctctaatt ccttttccaa gctctgaagc cacacctcca ggcatcctgc ctgcacctgg 111781 aggtccccat tcatggcagc ctctaattat tttccagatc ggtgtagcca gacctccagt 111841 ctgcatccct cagggactgg gtgtgtactt ttcttagcac agttaaaaat gcccatccaa 111901 ctctgccagc aaaggctctc tccttcttgg tgctctgcac ttccagctgc ttcagcgcct 111961 tctccatgct catgggggac ccatctactg ccacccaggt ttccactcaa gcccaccctc 112021 acagcacggc taccaccggg taccacaacc catgttgtgg tcacatggcc aacctggaat 112081 cagcagggac cgaaggctca cttaccttag gatcctgttc gtgatgccaa ttgtcaggtt 112141 ctagcccaaa ctaaagtcca aggggagttg gtgggtgggt ggcaggtaac tggaaaaaca 112201 ctcgagtagg cggtttcgac atggctttat tctctctctg ggtgcaagcc atatgtagtg 112261 tcagcagggt aattttacct tttacagaca atagtggctt tgagccaagc acgtgctcat 112321 atgagtggtc acctaatgca cctcacatgg catggttaca taatgtgtgg agttgtgtgc 112381 ctgcctccaa acccactgag tcatgctgca ccagaaggct gcctcggcct actcctgact 112441 aaagcacaac catctccctt agagtgggct aaatctactg ctatttatac tattagaaat 112501 tttaacacag aagttttaaa tatttacatt gttaattgat tttgaaataa taagcccatt 112561 acaggttaac ataattaaca tacttttatt aaaaatatct gtatttttta aaagaaaaaa 112621 aagtagcaac aacagtgatc cttggaatcg tcccacctca gcctcccaag tagctgagac 112681 cacaggcgca catcaccatg cgagctaatt tctatatttt ttggtagaga tgggatcttg WO 00/09525 PCTIUS99/17712 EPI-109 1165 112741 ccatgctggc cagggtggtc tcgagctccz aagctcaagt gatcctcctg cctcggtctc 112801 ccaaagtgct gagattacag gtgtgagcca ccacttctgg ccagaagctg gattctctgt 112861 cttgttcccc atccaatctg ttagactgtc aaatgccaaa taacctttgg aaaattctac 112921 tcgtaaaata aggagagaga taaataactt ctgagtatca tcattaaaat agtttgacct 112981 catggaccca ctgggtccca tgtggagaat agctctaagc taaagagtag aatggctggg 113041 aggggacata aacattcagc ccatagctgc tgaccacaat aacacatttt aagtctcttc 113101 ctctcctgct ccttgtgatt gcagacagac tcaatctgta ggagagctgt agagagaaca 113161 agctcaagcc cctgattttg cctacaaaga aagctgagcc cagcaaagtt aagggactta 113221 cccaaggtca cacagccaca cagcagagct ggggctgagc tccaggtgtc ctgctacaga 113281 ggccacttct ttctcccact agggactggc ctgtgattac ttcagaaaac aatggtcagc 113341 taactgattc tgaacgccct ttgctggtaa aagctaatct cctgaggaaa aatgtatgca 113401 ttggctgggc gcagtggctc aagcctataa ttccagcatt ttgggaggtg gagacaggtg 113461 gatcacttga ggtcaggagt ttaagaccag cctggcagtc atggtgaaac cccgtctcta 113521 ctaaaactac aaatattaag ctcggcatgg tggcaggcac ctgtaatccc agctactgga 113581 gagactgagg caggagaatc gcttgaaccc aggaggcgga ggttgcagtg agccgaggtc 113641 gcaccactgc attccatcct gggcaacaga gtgagattct gtctcaaaaa ataataatag 113701 taaaataaaa ataaataaac aaataagtat gcatcacctc aggtggtcag tcagctttcc 113761 caagacccca aagcacacaa tgttctttct ggtatgagtg acatggggtt cacagcacca 113821 caaagtccat gacttttccc tcagaagtga atgcatggct aattattttg tattttttgt 113881 agacatggag ttttgccatg ttgcccacgc tgctctcaaa ttcctggact caagtaatcc 113941 acccacctca gcttcccaag gtgctgggat tacaggcatg agacaccgca tggcctgcac 114001 ctatagtccc agctatcagg aggctgaggt gggaggatca cctgaaccgg ggaagttgaa 114061 cctgcagtga actgtgatcg ctccggtgca ctccatcctg ggcaacagag tgagatcctg 114121 cctcaaaaaa aaaaaaaaag tgaacacaca tgctggggaa gaggcctgca ggcacccctg 114181 ccagttctgc accagagcac actgtagcag ccctgctgtg atgcaggaag cagctccagg 114241 tcctgcagtc tgaagcatgg agcctgaagc ctggagcccc ccatccaatg ctgcgccatg 114301 ctcaccagta tcccccagca tcagcaccga ggcaccagct gcagataaat ttctcaccta 114361 aaatgttgag agatgttgct aaactgtcct tctaagggta tgtataataa tacggtcctg 114421 ccgatactga ataagactat ctgtttcatt acatcctcac aatactgaat atcattagca 114481 acttgaattt taaattgtgc taatcaatga aaatgattgc ctaattacta gtgagttgag 114541 gttatttaac attaatactc cttctgatga aatattttgc atttatcaca ttttacataa 114601 attctctcta tataattagc actagaatgt ccgacttggt tttcattgtt cctcacctgt 114661 ttggaaacac attaagaatg agggagagaa tggatgggga ctcacctagg gatgcatgga 114721 gctggtcggc agccactctg aggccctctt aacacttccc caccacacac ttaatttccc 114781 ctggtttgtc catagataca tccaacaatt tttatgtaaa taagaaagac tcagctttca 114841 atggaaaatg gtaggttgga ttttatgact gaagtggcaa aaagaaataa gggattttat 114901 tatgggggag gtccaaaccc tggtgaaaaa cgaaattcat tgaaattgtt tgaaaattca 114961 aggattaaat cagattattt tggattcagt aggaattaga ttactttaaa gccccaggat 115021 actttattct gtagaatgca tggaaagtat agaaaagaga aacaaagagg gaaagtcatg 115081 gcaataacc tcggaaggggt aaatagggag ccaaaggcct gtgggacgta accaactcag 115141 cattccactg gaggctttat gatcaaatag caagctattt atcatgaatg caggatgtgg 115201 gcaaactcac gactgctccc actgccagaa ggtttgctga gggcaatcac ttcctggcac 115261 cgagctcctt gaggttatct actgggacat ctggagaatg cagtcttgca agcctactct 115321 ggacccagca gctgacccct tcttccatgc ccctcttcct gctatctctt ttgcctaata 115381 aacatggagg gctgtgtaaa gctcagggcc cttgtccact agaggcaaac tgcccgctga 115441 ccccttcttc caaatatgct cttttgtctc atgtctttta ttcccgcttt caccccactt 115501 tgttcagtccc ccctagggcc gtgtgggtta catagtggcg ccctgaacag cgacagaatc 115561 aggtgctcta caagtggcgt ccgaacacag ggactatgag gatgtgaatg aagaagatct 115621 gctggagcag aggaattgaa attgacaagg tgaatgggga tcccgggaca agtctgccgg 115681 cagcagatat aaggtcagtg ccctaaagag gtactgggag cagtgcctta aagtagtact 115741 gggaatggga agttttctga atcagggtaa catggggcag aattgtctg ttgaagaaaa 115801 acattatgtg cagttgctta aagttttgtt gaaacaaact ggtgctcagg ttagttctca 115861 cattaactac gatgctacag gaagtcatta tgcataaccc atggtttcca caggcaggga 115921 ctcttgatgt agaaaattgg gatagagcag aaggattaaa acaggctcat caaaaaggtt 115981 ttcaagttga ttcttcagtt ttctccactt ggagtttagt tcgtactgta cttctgccat 116041 tatctccttg ttattctgcg ggacagcagg ctgaatgtaa aaatctgaaa gaatctgttg 116101 tcccacccac agctccagtt gaaaataagt aataggagag ggaggataaa aattggccta 116161 taccgccccc tccagttgca gaaacatctg taccgcctcc ttcggtggca gaaacagaga 116221 ccccaataca aagaatttta cgctctgccg ccacggctgg agagccctta ggaccttgca 116281 cttttcctat ttccgtaagt cctgatccaa ataatccaca gcagcttaat catgaacaca 116341 ttccactaga gtttaagttg ttaaaggaat taaaagtgag tgtggtaaat aatggcatac 116401 agagcccatt cactttagga ttgctagaat ctatgtttgg tgctatgtgt cttttaccct 116461 ttgatgtgaa acacttggca tgaacttgct tgtctgctag cgcatatctg acatggaatt 116521 taaactggca agaacagggt gcagaccagg ctagacagaa ccatgctgct ggaaatggag 116581 acattacaga ggataggcta ttgggtaatg gcccttattc tgacctggta catcaactag 116641 cactcacaaa tgctgcttat cagcagtgca cacaggcgc taaatgtgcc tgggccataa 116701 ttcctgaaga gggagtccca gtactatcat ttttacatat catgcaaggg tcacaggaac 116761 cctacgcaca atttcttgca agattacaag aggcagtgag gcatcagatt cctcatacct 116821 tggctgcaga aatgctaacc tttactctag cttttgagaa tgcaaatgca gattgtaaa 116881 gtgcactggc accggttagg tgtacaaaaa cttgggaaat tttctcagag cttgttaaga 116941 tgtagcaact gagctttatc gatctgcaat gttagctgaa gcaatggcta atttagctgt 117001 tgacaaatct aaaaagagcc aagggtcaaa ccctaaaatg ggaaaatgtt ataattgtgg 117061 aaaaactgga cattttaaaa aggaacgcca ccagatctca ggacagaaag gatcttacaa 117121 tgcttttccc cccggccccc agcggaaaga acacctggac tttgtcctcg ctatgacaaa 117181 ggaaataact cggctaatca gtgctgctca aaatttcatc agaatggcac ccccctgttg WO 00/09525 PCT/US99/17712 EPI-109 1166 117241 ggaaatgaga tgggggccta tacccgggcc tcacaaacaa zaagggcatt cccaattcag 117301 acctcaaccc tgtttcaagc atgggttccc agaggcatat tgagtccctc acccgaggaa 117361 ctccaggaag tgcaggatta gatctcccag ccagagaaag ggttacataa ggtggggaag 117421 acaaacccac caagattctc actggcattt ggggaccttt accagcagga tatatgggac 117481 taattttagg caaaagccac cttaacttgc aaaggcatta ctgtagtccc agaagttgtt 117541 gactctgazt atgaaggaga aattcaagta gttttattgt cacgagatct tcgggttttt 117601 gaaccgagag aatacataat gcaattatta cttattccct gcaaattaca cccttctcca 117661 tgaaaggaga aacaaggaaa taaagggttt gggagcacag ctacacggga aatctatcta 117721 tcccgaccca tagcctczaa tagacccacc tgtgtagtac aaattaaagg aaagaaattt 117781 tatgggttta tggataccgg agctgatgtg tcagtgttac cagcaggtct ttgttcttag 117841 agctcccaag atggcggcaa gccttttgtt ctctgacctg gagttcttgg cctcacagat 117901 tccaaggaat ggatccctgg gccatgcagt gagtgtcata gctctattag aagctcttcc 117961 aaaagtcgtg ctgctatcta tggactaaaa catactcaaa caataatgac ctctggcgtt 118021 taggctcaat gctcagagct aattgcagtc attcaggttt tacagctcac agcttcagat 118081 cctgtcaaca ttgtctgtgt tcagtttatg tcgtaaatgt agccggtcac atagaaactg 118141 ctacaattaa aagtacgcta aacccagaac tgctaattta tttttaagac ttcaacaagt 118201 tatttgttct agtgcagctc cttttcatat ttctcatatt ccttctcaca cacaacttcc 118261 tgggccgcta tctctaacta atgagaaaac agacaaactg attgcctctg tgtttcagca 118321 agctcaacca tctcatgtgc ttctgcacca aaatacttcc gcccttactc acatgttcct 118381 acaggtttgt attatattat gcagtatatc cctcgagcca cacctataga aggatgtaat 118441 ccacgaggtt tggctccaaa tgaaatctgg caaatggatg ttacacacac agcaaccttt 118501 gataagctga gctatgttca tgtgactata gacacttatt ctcatatgct gcctgctaca 118561 tgccaaacag gtgagacaac tggtcatgta cagcgacact gtctgtcatc atttgctcat 118621 atggggatat ctaaacaatt aaaaactgac aatggacccg cttatactag tcatgctttt 118681 aaaaatttct tgcaqctttg ggctataacc cataaaacag gaattcctta taatcctaga 118741 ggacaaggca ttatagagca ggcacatcaa acattacaat gcatgttgaa aagacaaaaa 118801 gcgggtatag gaggccaact accacctcaa taaaaactac atttagcctt atttacttta 118861 aattttttga ctcctggtat ggatggtaag actccagcag aaagacattg gcaagtgtta 118921 gaagaaaaga ggaaaattta tccaaaagtg ttatggaaat ccctggaaga aggaaaatgg 118981 aaaggtctgg tggatttact gacgtgggga agagagtatg cttgtgtttt tacaggagat 119041 ggacaagccg tgtgggtgcc ctcaaggtgt gtgcaaccat ggaacgggag actagaggaa 119101 cccagggtgg ccaaccatgg acagggtccc cccggtacga gccatgagcc agctgagcct 119161 gagtgcaaag acggagagaa ggccaactgg agtcacaaca cagttctaat gttatatttg 119221 taaagaatat cactactcaa cttacagttt gtgtttatag atatagatat agatatagat 119281 atagatatgg atatagatat agatatagtt atagatataq atagatatac actttaagtt 119341 ctagggtaca tgtgcacaac ttgcaggttt gttacatagg tatacatgtg ccatgttggt 119401 ttgctgcacc catcaactca tcatttacat taggtatttc tcctaatgct ctccctcccc 119461 cagcaccgcc tcccaacagg ccctggtatg tgatgttccc tgccctgtgt ccaagtgttc 119521 tcattgttca atttccacct atgaatgaga acatgcagtg ttttattttc tgttcctgta 119581 ttagtttgct gagaatgatg gtttccagct tcatccatgt ccctgcaaag gacatgaact 119641 catccttttt tatggctgca tagtattcca tggtgtatcc ttatgtcttt ttgacagcta 119701 agaaggacca gctccaggta aacaataccc aattgacctg taaatcttac caattatatc 119761 actgcattaa tcatagcaca ttgcaaacac ataatatctc tactttgatg attttaggcc 119821 acatccctgg gctatgtatt cctgttaatc tgtccgaggc ttgggctgcc acacctgctt 119881 tgcattttgt gaaacttctt ctaactgagc ttactcatca tgtctgtaga gccttagaca 119941 taataatttt agctattgtt tccttggtcg cactaataac ttctgttgtg atgtcctctg 120001 tagctttgca taattctatt caaacagctc agtacatgga gaactggaca cacacagccg 120061 accaagcatg gctacttcag aataaaatta acactgagtt acaaactgaa gtggtgttat 120121 gggaagtcag ggaccccaaa gagagggacc agctggagcc acagcagagg aacgtaaatt 120181 gtgaagattt catcttaata cggatattta tcagttctca aataatactt ttacaatttc 120241 ttatgcctgt ctttaatctc ttaatcctgt taccttcgta agctgaggat gtgcatcacc 120301 tcaggaccac tgttataatt gtgttaactg tacaaattga ttgtaaaacg tgtgtttgaa 120361 caatatgaaa tcagtgcacc ttgaaaaaga acagaataac ggtgattttt atggaacaag 120421 ggaagacaac cataaggtct gactgcctgc agggtcgggc aaaaagagcc atatttttct 120481 ttttgcagag agcctataaa tgaatgtgca agtaggaaac atatcgctaa attcttttcc 120541 tagcaaggaa tattaatatt aataccctcg gaaaagaatg cattcctgag gggaggtcta 120601 taaatggccg ctctgggaat gtctgtcttg tgcagttgag ataaggactg agatacgccc 120661 tggtctcctg cagaaccctc aggcttacta gagtggggaa aaactctgct gtagtaaatt 120721 tttggtcaga ccagttttct gctctcaaac cctgttttct gttaagatgt ttatcaagac 120781 aatacgtgca ccactgaaca tagaccctta tcaggagttt atgatttttc tcctgtcctg 120841 tttcctcagg agcatgtgat ctttgttctc ctttttgccc tttgaagcat gtgatctttg 120901 tgacctactc cctgttctta caccccctcc ccttttgaaa tccttaataa aaacctgctg 120961 gttttgcggc tcaggtgggc atcacggtcc taccaatatg tgatgtcacc cctggaggcc 121021 cagctgtaaa attcttctct ttgtactctt tctctttatt tctcagccag ccgacactta 121081 tggaaaatag aacgaaccta cgtgaaatat tgggggtggg ttcccccgat atgtgatgtc 121141 acccctggtg gcccagctgt aaaattcctc tctttgtact gtctctcttt atttctcagc 121201 tggccaacac ttatggaaaa tagaaggaac ctatgttgaa atactgaggg tgggttctcc 121261 caataaagtg gtaatgttga aatccacagt tctatggtta ggggaaaagc acaaagcttg 121321 caattgcagc agcaattgca ttgtcatttt aatcacactc atatttgtgt aaccaactta 121381 gaatataacc aaagtgagta tctgtgggac gttgtgaaag cccatttgca gggagctttc 121441 acatctaaca tcacctttga tattggtgaa ttacaaaaca aaattcttga tttacatagg 121501 caaattcaag agtttctgcc ttctttagaa gactggacca aattccagca aggcctggag 121561 agcctcaatc cttggaccta tctaaggcac tacattaaca tcttacatgt agttcttgga 121621 ataatattgt tttgtctcta tcttctgttc atagcctgta aaattggatg gaccaccaat 121681 cggaaaatga gagctgccca ccctggcctt acattctttc aattaatca taaacagaaa WO 00/09525 PCTIUS99/17712 EPI-109 1167 121741 gggggatt tagggagcct aaggctcgtg ggactgacca actcazatt ccactggagg 121801 ctatatgata aaacagcaaa ctgtttatca tgaatgcagg atuzgggcaa actcacgact 121861 gctcccactg ccagaaagtt tgctgagggc aatcactrcc tggcaccagg ctccttgagg 121921 ttatctactg ggacatctgg agaatgcagt cttgcaagcc tactgtggac tgagcagctg 121981 atcccttctt ccacgccccc cttctcacta tctcttttgt ctaatcacta cggagggttg 122041 tgtaaagctc agggcccttg tccactagag gcaaagtgcc ccctgaccgc ttcttccaaa 122101 tatactcttt tgtctcttgt cttttattcc cacgcttgcc ccctttattc agtttcccta 122161 ggtccatgtg ggttacatag tggcaacctg aacaatgaca gaatcaggtg ctctacagaa 122221 ataacttttt aaggaaagat ttgggaccta gagaccccag gagacataca caaaaatgat 122281 aagaggatgt gcccaaacca gtcttaaagt tgtggcacag ggtgaggaag atgaagctgt 122341 tactgaacct cagagagtga ctggtgttac agcaaaagtt agcaatggcc tgaagggagg 122401 gtttctgaaa tcaaatatga atgattcccc ctcagggaac ccaaccttgg gaactactgc 122461 atggttctct gtatgggaaa atatcattaa tgcaggataa attgtgaaat atcacaggaa 122521 gcatcctgca tctagtcaat cttctgtttc tggggtggcc tgtgcagctg tgcaggcaga 122581 ggcccaacca tcctggtgag tggcacacag ggactgagat ccagccacac ctaccaggcc 122641 atgctctggg aagggggtgg gacctgggca aaggacacct ctctaggact gcacagaagc 122701 ctttgtgggt gggtgggaca ttcctgtgat ggccttctgg ctgggcacta tgaaatgctc 122761 tgaagatttt tccttgcact gttgcactaa ccccagtcct ctatcactgc cccttcctcc 122821 tgggcgactt cactgatgtt gtggccatgt gaattctctg gccaatgaaa tgataaagat 122881 gatatggcct ctgccaagca gacactgtaa gtattattgt atgatgcttt tgtctctttt 122941 tttaaagtta aagcagttta ttaagaaaat aaaggaataa aagaatagca ctccataggc 123001 agagcagctg cctctgtctc ttatattttc ccctctgcct caagcccaac atgcccaaaa 123061 ttggggctgc tggttcagcc tgggtctcag aataaagaca tgagccacag atccattgct 123121 gacccatgat ggagatggac acaagagaga aacacatttt tgtcatgtta gccactaaga 123181 ttttgatttg gaggccattt gctacagcaa tataacctag cgtgaacaga gagacacagc 123241 gatgttccat ttcttttcaa cctggaacag gagaatttca taggtgggcc tcaatttcac 123301 tttagtatct tatttagaca agaaagttca tactgttcaa atgtcatgtt taagagtgct 123361 ggcattatca ctgctgtggc taccccatca gatgttgctc actgactaat cttctcatgt 123421 tagtgaggat ggacaacata tcaggccata attcaaagta gcaaatagga aaagagcttc 123481 atcctagcat tatgggacct taattaatgt cctttcctga caggtttcag aggcttttgc 123541 aggcagcagc agagctattc atctcactga cagtggggaa catggccaaa tggttgcccc 123601 cacaatggag gcagagtttc aggacacttg tctgatctct gcccttgaag gaacagtctc 123661 accctgattg acacttttgc ctgttatgtc caaagaacca atggaaaagc aggaaaatta 123721 ttccttcttc atttctctct tcattattta aaattattct gtcttcactt ctctctcctt 123781 ttctctgctt cctacttagc tctttagaaa tgcaattata atcttttatc tccccttcac 123841 cagacactcc caacagggca agttcatcta actatgtgct cttagttaga cgctacagag 123901 cagaactctc tcccaccaag agactacctt gagacataac agtcaattca caagccaaaa 123961 tatgcccgct atgaaactct cccatctgga aattttttgg ctgcttttac aacctagttt 124021 tgcccacaaa ggcaccagca gtaaccaact caactgcctg gtagacaagg caccaaagcc 124081 agtacccaga ccctctacct gctcacttcc tgccttgcat gccacgcccc ccatttaaaa 124141 gcctctgctt tctgctccaa aggtgaagca gttaccctta aggaaagaag cctgtacttc 124201 ttcccctaag gtagctttgg aataaaagtc actttatacc aaacctagct cttgttaatt 124261 agactctgca agtgatgagc aactgaacct acatttcagt tataattcct atgcttgttc 124321 ttcctgccct gccttgggga cacgcacaca ctcccaggca catacatgca cgtgcactga 124381 gacagctatg tgaataacca acaagatccc cttaggaaaa ccggtgcttg gcctggcctt 124441 aaattccaga cccttgggca tcatacccaa gactgcaaga aagaggaggg gctggacctg 124501 aaaaacttgg aagggaaggt ccaactgtac aggtattttg tcaggcatgt gatttcagta 124561 taaaattcta gaaaagatga gtgacacttt ataaggagag aatatcaaca aaatttctca 124621 ttttacttct tgctaagacg acagcaggga attgtaagca gatggatggg caatccccac 124681 cttcagcagg ggaggccaag gccccaacac acctggggag aagagctggg ggcagtgaat 124741 ggctgaggct ttcttgggga gctgggccat cttcttcggt tttacttcct gaggaattca 124801 caggcttcca ggagggctgt gggacacaac agagcaagag attcagaaac tgatttcttc 124861 cattaaacca gttatttaat ccaataaatc aaagagaata ctaagagttt tctctgccct 124921 tctcccatca ctgagtcagt gcttgccaca ctcatattcc cactccccta ctcctagcga 124981 ctacggtgtt caagggagcc agagtctagc cctcaccagc cagggtgttt ccctgctctg 125041 gcctgagaga cacaaccacc ctgcacttgt ctctgattga atcgactgtc acattctcaa 125101 gttcacaaga cattggtggt cctctagctt ctcccggaat gtgaacctgt ttgcaatcat 125161 gttcacctgc agattcactc attcattcac agatccttac tgagcacctg ctttgtgtga 125221 gttgctgtgc taagtgctgg ggacacagca tggatagact ggcctgccct caagaagcat 125281 gtggtctatg cagtcctgag ctggctgctc acaagaagag ccctgtagcc atatttctca 125341 gagggtggtc ctgacctgca tcacagtgac ctgagttgtt tgtcaataca gaaaagggtt 125401 tctcaacctt ggcactattg acatttgggg cctgataata accctttatt gcagggggct 125461 ggctgtgctt tgtttagtag catccctggc ctctacctat ttgttaccag cagcaccctc 125521 tatgttgtaa gaatcaaaaa aatgcttctc acattgtcaa atatcccctc aggggaaaaa 125581 ttgtctctca ttgaaaacta ccgataaaga catttctggc cctgccccca tccttggacc 125641 aacagcatcc ctaatgcccc caactctggg tgagggacca ggaataggaa tctgaatgat 125701 tgcagtgcac agggagctgt gcacactgaa atcccacagt tatcaccggg agccttacaa 125761 tactctgtga tgtcttctaa atatttttaa gggattaaat taatatcaac atatttccct 125821 ggttaagatg tgttttccta cacttgaatt tttttgagat tttgttttct ctatagttgg 125881 catctatggt aactgtctag aatcagattt tttttttttt ttttttgagg aagggtcttt 125941 cggtgtcacc taggctgtag tgcagtggta caatcatagc tcactgcagc ttcaaccttc 126001 tgggatcaag caatcctcct atttcagcct ctcaagtagc tgggactaga ggtgcttgac 126061 accacaccag gctaattttt aaaattattt ttgtagaaca aggtctctct gtgttggcca 126121 cattggtctc aaactcccgg gctcaagcca tcctcccacc tctgcttccc aaggtggtgg 126181 gatgacaggt gctgagccatc acacctggct ggttttgtca tttctcaatg catatgtata WO 00/09525 PCT/US99/17712 EPI-109 1168 126241 tatgcacctt tcattttact gaataaaatg gattatcagt ttccaaagat ttcatgacag 126301 tgccgtcact atccgtacta taaaatttat aaaaatttat tacatactgc tctattttat 126361 tctctaatta ttttatcaat gagattataa tttcctgaac tgtaaagaga tattatcttt 126421 ccttaacatt tttacacctg tgttcgttcc tagaatgctg tttggccctc aaaccttgac 126481 cttcacccat ggtggtttct cggggatgct agctagggtc tacttacggg aggttgagca 126541 ct-tttcaga ttagtaatgc ctgcgacata ctgtggtccc aaatattttt catatgttgt 126601 tttaccatgg agtctggcca gacactcagt gttgtcattg aacagaaggt ttttggtttc 126661 agactggaat aagcaaaact tgtccgggca gtcagatcca tttctcccaa atttagcctg 126721 cgacaaaagg qcagacagtg agtagctaag gaaaagagga atttgtgggt taaaggaggc 126781 aaaggggtat ttcttccacc caagaacagc cctgagaaaa ccatggggca gaaggagctg 126841 agttctggag tcattccacc tccttagtgg agtcCCCCac cccacactcc tggtggCagg 126901 cccaccttgg gcagcatcca ggcctcacac cacttctggt cctacctcct accatctgcc 126961 atctttcctt ccttcttaac ctgtgacctt ttcccataca acttcttatg ggtgacaagg 127021 caacaatgga ggggttttga gatctgccct cacaagtcaa ttgctcagga cattctaata 127081 tgcagctctt ctagagaggc aggctgctag gaaaacccag gctcagccac taaccagctc 127141 agtgtgcagg tcggtcaccc tgcctccctc acacagttcc tgctctgtcc caggctccca 127201 tgtggggaga ctgagaccca aacccctcag tcacggcagc tctctcacca gcaccactgt 127261 gtgtgcacat taagagctcc ataaaggcca gttatggtgg ccagtcttgt tattcctgag 127321 ttgttttctt caaaagcaca cagagacatg atgttatatg ataaaaatag aagttctaat 127381 aaaatcccag attttaagaa aattttggga tttcgttcaa atcacattta gagagcccta 127441 aatctatagg gcaccttctg agtttgctgt tttagaggcc tggtctagag cactgttcac 127501 tcggcccagg ttcaggaaat gtcacctgag taaaaagcac tatactaatg catgtgggag 127561 gaaggctcag tggcttcctc atttgccaga agaacagcag gagggaaaaa gacagcctct 127621 gagccaqgca gtgatggcaa caaggccagg gcacagagtc tcagcagaaa tggagtgagt 127681 cccagaaagc ccagagtcaa aagcctctgt tgttcttgtt gacactctgg gcaacgccac 127741 agcatgaagc caatactctc accatgagct tcaagtagag gactagagag gatcgagtgg 127801 gctggtgcac ctagctctgt gatctcctca cctaacatga gcccacacag ctaagaaagc 127861 actagaagcc ctgtggtcca tacctgttgg tggagcaaca cctgtttcag gcgttccacc 127921 ttatccatcc gagacaccac ggcatgattc ggggccatgg caagatggca gcttCtagcc 127981 tcagtcacag gcttccgttt gccatcgagg cacagcagcg caaagtctgc cagcttcaaa 128041 tccttagccc atgcgtcatt gttatttcct ggggagaaaa agaaggtggc atcatccacg 128101 cctcccctgc ttagccaaga agtctcttct gggtgggtgt ggccattcca ctgacctccc 128161 aaatgcacac actggggttg tggtgatgtg aggaacagag aaggagcttc atcctacaca 128221 agctgtacaa acttcaaata taccaaatat tagtgctgtg tccatgcaat ggaatgttat 128281 tcagcaataa aagggagtga agttctggta catcctgcaa tatgcatgaa cctcgaaaac 128341 gatgctaagt gaaagaagcc agtcacaaaa gaccacacaa taggctgggc acggtggctc 128401 atgcctgtaa tcccagccct ttggaggcca aggtgggaga atcacttgaa gctaggagtt 128461 catgaccagc ttgggcaaca tagcaagacc tcatctcaaa aaaaaaaacc caccacatat 128521 tatatgactc catttatatg aaatgtccag aataggccag cctatggaga cagaaagtgg 128581 attgatggtt gccaatgctg aagaaggata gggcaatgac tgataatagg tgcaagggtt 128641 tctttatggg aggatacaag cgttctagag ttggattgtg ttgatggctg cacaactctg 128701 tgaatgtgct ggagatcact gaattgtaca ctttgcatgg gtggattttt tagtatatga 128761 attctacctc aataaagctg tttagagttc ttattttttt aaagaagaaa accctccacc 128821 tatgccatat ttttcagtga gttccagaaa aagaatagat ggtttacatt caaggagaaa 128881 ttggtttctc ctccctttca tattcaaatg ctattagtgt aaccagagaa aggaaaggaa 128941 cttttatagg tttatcaaat atatacagcc aattctaaca aaatacagtt gtaaagtacc 129001 ggagaaaatt aaaattaaat ttgacatcaa tctgatccct ggagattact tcagttaatg 129061 gcttgtaaat tctaaatgta attgtatgca tgtctatgtt tgtgCagatg ccggctcatt 129121 gttccggctc ccgtttgtct ctctgctctc tccctttaag aaagcacttt attcattctc 129181 ttggattcct ctatttgata ttgaaataat ttcaaattta catgtcttgt tttaatctct 129241 gtcccaagag acactagaag gagcagaagc agaagggaga agtggctgag actgcagtga 129301 ttactgaagg agggaggccg aaagtggaga cagttctttc tcaggaaaca gaatagcaag 129361 tcacctgctg agacttgggg gttggaatgc tgaagtgggg ctaaggagac agatgcagat 129421 tggaaggtag caaatggctg aggaccagga gagagagtga ttgttcaaac attggctgga 129481 agattatctt ccatcatctg caaccacctg taattttgtt cccactaact cccaaggagt 129541 ctccagacca aggctcacat ggggatgaat gaaggcctct acttcctttt tcataaaggg 129601 aggcttcatt tgcatatgtt cacccagttt gtagcatcat ccacagtttc caataggcat 129661 gcatgatctc atgtgggcag acagtgtgtt tctgtggttg actagaggaa gccagggaga 129721 catttgctac tgagcatggc tagtatctgt gtgtgtgaga gtgagtgtgt gtgtgtgtgt 129781 gtgagagaaa gagagagagt gtgtgtgtat gaatttcgtt tcaaaatcca tatgacacct 129841 acagatgtta tcatgttgtc tattgagata aagaattttg gagttctttt aatcacaaat 129901 atggaaaatg ttataaaacc ttcccaaagg caaatctgaa cactaagatg tgttgtgatg 129961 ccaaagactc tgctttgaag gagaaaagga aacaccttca cctaccatca gtgttctgca 130021 agacagtgac atctttcaca aatgcaacgt ctccagcatt ctcagccagg cacctaaaat 130081 gttccagaaa atatacacat aattacagaa gagaaactag tggggctttc ataaatattt 130141 gtaatatgca ttccaaaaac tgaaatatgg aagtaaacat ctaaaagaca actatttcta 130201 ggaatttact gtttacagcg gcagattgaa cacaggtgta cctgccctcc ttttaaaacc 130261 ctatataaaa gacattacaa aaccaagaaa tctaaagata tgcgacccag gaaacaggca 130321 atctaacatg aagtaagaca aaggaaagca ccaaaataat ggtcaacagg acccccagga 130381 ccacagatgt gcaggcggcc tacacagcaa ccagtccaaa ctgcagcagg aagatggatg 130441 ccttctggag cagcacttcc aagtaaatga tgaaactgtg atagcaccca gagagagaga 130501 gagagagaga gagagagaga gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt 130561 gtgtgtgtgt atgcatgttg ttaggagatt tacattactg gcagacagtt tggggatgag 130621 atagtgatgt gtttttttaa gtgcagaaaa ttaagcaaat aagaaaagac atttatgaac 130681 tccagagtaa acaaaaagtt tgtacaataa gggaaatata atatgagaat aacgcttaca WO 00/09525 PCT/US99/17712 EPI-109 1169 130741 caatcataag tactgaatat aacattaaca tgttaagtgc zgaagagagt tgaagtctgt 130801 agztgtgtgg tggaaaaggt gctgggggca gtgtgagagg ctagatcttc ttctatacta 130861 caaagtcagc agaaagttaa aaattaagaa ccagcattat aaggacgata gaaataaagg 130921 ggtatgacac tggtttcaac ttttaatgat tttgctataa atttccccaa tctagattCt 130981 agatataatt taaacaaaag acaagggatt ttcttccagt ataattagga atattaaaat 131041 gtgggtgttt ccagtgaact aataccttgc tgcaggtctg aaaaaaaaaa aaagaggagc 131101 acatgcttct ttcgggctct tatgagacat gtgttcagca tttctgagta gaatcacatt 131161 tccatttgca aatccttagt cccttaaaga tatttttata cattcacaaa acattttttt 131221 ttgttttggg tcttttttta tgagccactt atatagcaaa agctactttt ctgtcattcc 131281 attactggaa caaggctgtt gaatttatat taaaaagttc agacaccctc agacacatga 131341 cgccatctgg tcgtgaaatg tactcttggc aaatggagga aaaggaacag gggaagatcc 131401 tctctgcacc cttcacactg gtaaatagtg cccctgagaa gcaacacccg gatgaatggt 131461 gctgtaaaac gtggggtgtg gttacaagtc actaagtggt tataacttat gaattctgaa 131521 aacttgtttt ttggcttatt tttcacttcg ttactggaga ataacactgc aattctgcca 131581 tctctttgcc atttctaagg ccaaagtcag agaaaaaggg aaacctaagc catagtcatg 131641 acctaggtga gaagaaaagg ggcggcgatg ggaaagagaa ttcttcccca taaatggaat 131701 tgtaggaagc acttaggata ccacactcta cccatttgat tttcaggacg aggctattga 131761 ggcctactgc tgttgatctt ggctcaaagc cacagggaga agcactgcgg agctgaggtc 131821 agacagccct ggtgccagcc tccactctct ggggcggtgg gtgtggtggg gacagccctc 131881 actggggcca cccatgagct gacccacagg atgaccccca ctctgctgtg acaggtcaca 131941 tctggctcct tagaactgca atgctgacat gctgagggat gaggtaagtc cccatcctga 132001 tggagctcag tcacagactc accggaaagc cccagtgtag ccgtagtatc tctcgttgct 132061 gtzgggcacg cacttattct caccctgctc gtcgccaata cacagagcac agagattaga 132121 tctcgggtca gacccagggg cacagctttg actgaaatat tcatctggag agaaggaaca 132181 cggggagtca gctcttcaaa cctgagtcca cacaagcaac ctttacctaa cagccgatgc 132241 agggtggttt cagttcatta gacttcccag gacagcaatc tagatagaac acactcacca 132301 tcacaaagca acatgttgtc accaacatag gacccaccag aaaagcttca ttcagactgt 132361 aggcacagat ggacacccaa ctaaggctgg ggatgagagc tgtggCtgcc tggagggtcc 132421 cgtcatcaca gccttgagct ggggactcag ctcatgaccg tgatggctgt gtgcagcaga 132481 gcctgtgagt tgcctagtcc aggatctgat tttgttttta tcagtaatgg aaaccctgct 132541 ttgtatctgg gtgcttggcc ctttjgtata aagactagac ttatcagact ccctggggct 132601 catatggcca tatgggtagc tataggccag tgaaatatca gcaggagtgt tgggcgccag 132661 cttctcagaa acatccttga aagacaattg gtacatgcct tttgcccttt cttctccttc 132721 tctttcttca tcctgcacat agaatgcaga agcagggact ggacttagag atgcaatgtg 132781 ggccatgagg tgaccttgag catgaaagcc acacaaatgg cagagtagcc aaatgattaa 132841 agcccaggtt ccagacccca tattgtcttc ataccagccc taggcaaacc acctctggac 132901 tacatgacac agaaattaac ttctgtcttg tttaagcctc tactatttca ggagttttct 132961 gttccttgca gctgaacctg atctgaattc gttcattgtg tgatttaacc caagaaagaa 133021 taaacaaagg tgacaagaaa gctctgcccc actgagcaaa cgtcacccat tatcagactc 133081 ccactgctgc tggaagagcc acactatgtg tcaacctcag gaaaagctgg gagttcccat 133141 tccatcctgg cagtttccct acagctcaga ggctgccatg gagctggtga ggagcagagc 133201 cacgtgaaag ctgcctgccc cggccaggat caaaaaccca tgcagtggag cccctgccct 133261 aggagacgcc catacaagaa gggagtcaca ttgaggatgt gctacacacc atgccacggg 133321 gcccacagca ggcagggtgt ggctgatgct gactaggatg agtgtggggt gtggtgggga 133381 gagaaaactg cagaagcagg tggagccagg ctcttgaggt cttattcagg ctccgttgca 133441 gtgtagagta agcgtcagtt ttgcttagta acaggagtca cctttcatga ggcaggcaga 133501 catctttccc caagctggga agccagagtt taagaggaat ttaggtctgg agctccaaga 133561 ggtaaaaagc atttgcacat cttggaactt gcatttattc ttagggtgca gcgaaatagg 133621 cagatattcc aatctttaat cttggggtgg ggtgaatggg gcatgggaag tgctgtgcag 133681 ggaaaccccc agtgcaccca cgcctccagg gggcagccac agggagaatt tccttatgct 133741 ggaagaggcc tgcaggccac tatcagcctg caaatcccct cccctccctt ccctaaggtt 133801 ccacagcaca atatgcctac cctccagggt ggcccaccca ccgcaccttt ggaactcctt 133861 accaaatttg caggagcccg tctggttgaa gagcaggccc atggggatat tccagcctgc 133921 agtcctgtcc acggcggtgt ggcaggactt cttgcctttc acagagttcc aggtaaggct 133981 agtgtctgat ctcctaacca ccgccacagc aagatatcct ggcataacag atgacagaaa 134041 aacaagtctt aacctccagg aggcctggca catggattcc agtggagctg tctacagccc 134101 aggccaaaac aggccaagaa gcaacaccag gcaatgattc cctcaaagaa ctggcctttt 134161 taggtagacc gagaaagcat aagctgctgc cttatgttaa ggtgagattg atgaaataaa 134221 acagtaagaa aagctgatta ttttagtgat tacaggggac tgtcttcaac cagccacaca 134281 atgtccctga gttacaaacc agcaatgcat ctctcagtgt aagcttctac agcaacaaac 134341 actataaaca acaagagaga ccccaacagt gcataaatca ccaaccacag tgtgcatcag 134401 gcaagagcac caacatccag ccagctaacg gctgtgtggg tacaggggca catgtcccca 134461 gggactgccc tgagctgagt ctgaacccac cctgcactgg ttgaactcaa catggttgcc 134521 gttgtcctcc tgagagaatg catctgacag acacccacca agggcaagtc ttttctgaaa 134581 ctgagcaagc accagctctg gtgggcagga ggagtggtgc acagagcact gggacacgag 134641 tcccaggtca cgaggacccg gggtcaagac caggatctac cacagtatta cctatggctg 134701 tgagtgagat cctgggcact tggggactct cggtgccact gtttcctcat ccccatgagg 134761 tggggaagta gcacccccca ttccatgacc atgacaaaat gagggactat atggatgttc 134821 tttgccaagt gtgaaggtca atataaacat taattagaac tattcctctg tgaattattt 134881 gcacccttaa aattattgct cctagaagcc ctatagcttc tagggctgca attctttctg 134941 ttttttttac agttcctgcc acttcctctt ccagcaacaa gaacttatcc ttgaccctga 135001 aagtggctaa tgccaactca ccttccacag gtctatccac acagttagga tcagggtcac 135061 tgcttgttg ggatctgaa agaataaaga caagccagac atcattatcc attcagatgt 135121 agtgagaagc cacaaactct taaatctcaa tgatgcagaa tcaaatccaa agagaccgtc 135181 ccagcagttc catgcaggag aaatgcgtct atatgttcaa caaaagacat ggcacagaga WO 00/09525 PCT/US99/17712 EPI-109 1170 135241 ttcacaactg cattattcac cacagccacc aactggaaac tactcaaatg cccatccaca 135301 ctcaaatgat gaataacc agtagactca cacagcgacg agactgaaca gtctacaact 135361 acacacttag gtggatgaaa agcataacga tgagcaagag aaaccagaca taaaaaaaca 135421 catgctgtgt aattccttta acatgaagtt taaaacatag gcaaacttag atctgcgacc 135481 ttagaagcca ggagagaggc rtcccttgca ggagtaaggg ggcgggggac aggaggacat 135541 aaggggcttc tgaaacttac agtgtttgtt ctgggcccua gagcatggac tgtaCagtgt 135601 gtgaagtgcc atgagttgta catttatgtg cacttttctg tttgtatgtt ataattcact 135661 gagatcttct ggaaaattaa gaagataaaa ccaacctgtc ccttgttaat tctcaacaca 135721 ataggctttg tgggtaacac ggcccctttc atttcttctt tccctgattc tcccttttga 135781 atgtatctgt tcatcataat gtttcacctg cattcaccga atgggattac tcatagcccc 135841 actcccatga cccagaggga atataccaga ggatgctaac tccacttact gtagttctct 135901 gccaggacag gcaccaaacc acatttgcct gcagtgtaCa catatcctcc atccaaactc 135961 atggcatcag cttctccttt ctgcaaagac agagcagatc tccagcacca cagtgaggct 136021 gcatcccgtc ctgcctgtct atatagctct ctgagagaat ggttttctgt caggtgacca 136081 gtgaaacagc agaaagagat ggactattca aactgagcag ccagaggaaa caccgtgtgc 136141 accactaatt ctctcccagc cctgcctact ttctgggctg tcaattcaac tggaaagacc 136201 aggcacaggt tgcactaatc ctctgtcctc tgagcaaaac cttttctgtg tccctggcac 136261 tttggggaca ccttcctgga gcagtctcac tgactgagga cacagatggg aacagctggc 136321 ctcatctaat ctgaactcat tagcactcca ctccaagcgc tacacagaag ttgtccaaca 136381 cataagctga agtcgtcata ttggcccacc accagaatga acaagtcCag gctacaacac 136441 aggatcatgg actcatcagt agtatgaaac ttcctctttg acccagtaat atttttacaa 136501 ctatattaaa aatagagaag tggacaaaga tttctactca agaatgctca ccacagggtt 136561 attgataata gcaaagtaag ggacaaagag gaatgggggc atgactaaac tgagccatat 136621 tcacataaaa gatatcctgg aagcatgttt aaaaaatgtt ttcgtccgag tgctgtggct 136681 cacacccgta atcccagcac tttgggaggc cgaagcagga agattgcttg agcccaggag 136741 ttcgagacga gcctgggcaa caaagcgaga ccctgtcgct acaataataa taataataat 136801 tatgcaggtg tggtggcgta tgcctgtagc cccagctact tgggaagctg agatgggagg 136861 atcacttgag cccaagagtt ccaggctgca gtgagatgtg gtcgcaccac tgcactccag 136921 cctgggtgac agatcaagaa tctgtctctt aaaaaaaaaa aaattaatgc tttccaagag 136981 taaatattca tgtggaagaa tgcccattat acgctgttta gtgaaaaggg cttaaaaacg 137041 acatactgca acacttcatt attgttgcat gcatatctgc agatgtgcag agaaatactg 137101 gaatggagaa ttagccagac tttaaccatg tctgtccctc tgtgtgagat cacaggtggt 137161 ttggggggtt tgttgttgtt ttgttttaac ataatacctt tccatatttt ccaaattcct 137221 tataataatc ctgagttgtt cttataacca gaggagtggg aaacccacag taaactgctt 137281 tttgaaacta aaatgctttc tggccctgag cacacctctc caggcatccc tgcctcaccc 137341 aggcccccgt ggcctctttg actgttgact tcactttaag cagatgccca ggccctaggt 137401 cttccaccgg gcccaccgcc cgcccctgtg atggagctcc ctaccagcac cagggcgatg 137461 cagtcctctg tggtggaggc cgaggagcag gtcacgctgc cttcgctcaa gccactccac 137521 tggttacact tgcgcagctc ctgctcgccc accgcacacc acacgacccg cgcacgccgg 137581 gcagccactt cctcctcacc tgccagaggg aagaccgcag gtggctgggc aacctgagct 137641 ttgccaggtt gtccaacctc cccagagcca gggtcctgcc cagactctcc ctggaacagg 137701 agctacagta catgtgtgga catgtggacc cataccctct cctcctccac ttctcagctc 137761 caagcccctt cttcaggtcc acagagctcc ctgtgtttcc cacttctgtt cctttggaga 137821 agttccctgg cttctaatct atccattaat ctttagagtc aggaggcgcc tattgtctct 137881 gtctctgagg ataaacgctc catgacccag agaccagtga cagtcccaag agatggccta 137941 ggggaccttg agcccaaccc tgacttcccc taacgcctgc aatcaccacc aataactacg 138001 gtgcagcctc tgggttcccc cagactccca cccccagccc cccagtagag aaggagccat 138061 agctgagttc ccccaccatg gtgtccccaa ctaagttcaa ggtctgggcc tgggaagtgt 138121 gggtaaatcc aggcccccgg attcatccag gaggggtcct ggctatcttt gttcatgttc 138181 atgtttctca cttaatagga ggcaaactga tttttctgcc aggcctgggg agcctgacgt 138241 gcactgatca ggtggccaga ctattctttt agagacacct gacctaatcc acagaagaca 138301 ctcacacctg catcaaacct ccacgatgac cccacagtgt ctgggaaaag gagtgaccgc 138361 cacaaagtag ggccacctgc tgggaagtag aagaccacac caggcggacc tcaggaccct 138421 cctgggctca ctcacttttc ctcaagttct ggatggcagt gaagtagccg gagccaaggt 138481 acagcccaga atctatcctc gggggcaccc tcgaaaaccc aatggcagag tccttgaaca 138541 gcagatcttt ctgcccacta ggggagccaa agagctggaa tttcggtgac ttgtcctttc 138601 caaacttttc ctaattaaga aaaaatagaa ttatggtgtc aatggtaaat agggaggaaa 138661 caaaaaaatg atgttaaaaa agagtatctg gagctttggg atcattctaa ctgagagcag 138721 gagcctcggt tgagaccctc ctgcagaggg acttgtgcca tctcggagac ccaagctcag 138781 ctatggctca ttctttgaag agttgctgag gtccaagcac cttagggccc tgagaagatt 138841 gcatcgacca ccccctgctt ctgctcccat cataagacgc tgtcagcccg tgtgacagaa 138901 gagtttcatt gcttctgctg cccacagtac agcctgggca agcagcccaa tgcattagtg 138961 tgctatcctg cagcaaagct acaggacttc tggagtggca gaagtcaggg aagtaagaaa 139021 ccttgctccc tgccccccat atccaagcaa gtggggagga ccgtgggtga agatacctgt 139081 gcctggcgga gaagattcca gatggcatcc tccttgccat tcacacttcg tgccacaacg 139141 gcatgagaag ggacccgggc cagatggcag tctttgaact tgtccactgg cttccgagtg 139201 ttgtctgggc agagtaactc atactcgtcc ctttcagcct cgtctgacag gtcctctgca 139261 gggaaggtga ggtgggaggg agtctagata agccgactcc agcagtaacc tcgagctata 139321 gttccccttc tccctataga attttgagct tggggagata gctgacaaaa ctgagggtca 139381 gaaaggcagg ggtttgctcc agaacactca gaaaggtaaa ggtagtgccc caaaagcctc 139441 agggggcagc cgaggtgtga tcctcatcct aaatcactta ggccaccctg gggttcccgt 139501 gcagctgctg cctggcaggc cagagaggcc aaaccagacc cgtctgtttc tgcggcatct 139561 c agcctggaa aagtcacttt gcagagacaa gctcaggggg ccaccaaggg ttgctccctt 139621 actcacatct ctgggaagaa taaaaatgac aaaaatgtta acaaggcagg gaataaggca 139681 ggaaggtgag acactttcca acactgagta tatcaaaaga aggggaagaa tggttttatg WO 00/09525 PCT/US99/17712 EPI-109 1171 139741 ggcaaatgtg gaatatcata tataagttgc ttcagaatgt gtaaagtgaa 139801 aaaaatcztq cccgagtcat tttatgagat tagtacaacc ttgatgtcaa aatcagaaaa 139861 agtataggag ggaagaatta aaagtttatt ttacttacga acataaatgc aaaatttgta 139921 aataacgtac taactaactc aatctcacag agtatttaaa aaactaatag attggaatga 139981 aggtttacca gtgtattcca ttaacaaaag aatggctgaa catcaaaaaa actaaagtaa 140041 tctgcattta atggcagaaa accatgagat cgtcttcatc ttaatagatg cagaacgatt 140101 gtttatgtgt tcaacatcta tttgtgtgtg gttttttttt cagcctcaga aaaatagtaa 140161 tagatagaat cggtaaagtt tttttgtttg ttttgagacg gagtctcact ctgttgccca 140221 gcctgqaatg cagtggtgcg atctcagctc actgcatcct ccatctcctg gagtcaagag 140281 attctcttgc ctcagcctcc caagtagctg ggaccacaag cgcacgccac caggcccagc 140341 taatttttat atttttaata gagatggggt ttcaccatgt tggccaggct ggtctcgaac 140401 tcctgacctc atgtgatcca cccgcctcag tctcccaaag tgctgggatt acaggggtga 140461 gacaccacgc ctggccataa gttattggct tgataaatgc cattaatcta cagcaaaaac 140521 cttactaaaa gaagaaaatg tagacattca ccgcaaaatc aggaacaagg caaggatgcc 140581 cactgttaca atgccagcac aattctagat atccagatca cacaatttac aaaagaaatg 140641 tgagatataa acactggaag gaaaaagaca cactcttatt taaaaagatg atatcgtcat 140701 ctacaaaaaa ccaatgaaac caacagaaac taataaaact actcagagga gtaacaagtt 140761 ataagagcaa cctacaaaaa tcagatgtta tcctcattaa caataaccaa atagaaacca 140821 atatggacta taagatgtta caatagcaac taaaaccatt aagtagctaa taattagcct 140881 cccacaaaga cacatcagac ccacaaagga aaaattttag ttctatcaaa gaaactaaaa 140941 agaggtgtga tcaaatgggg gagatttagc atcaccatgg actggacaac ttaatgttat 141001 aaatatgctg atttttcatg gaacaattta aattcagtac aattcgaatc aaaattaaag 141061 tatgattttt tccagaaatt caacaaaata attctgaagt tttagctgag tatatttgaa 141121 aaggaataat aaagtgagag gggagaggga gctctctctc attctctctc tcttcctctc 141181 actggctctc tctctttctc tocaccagat agtaagaccc attggtaagc cacagtaaca 141241 aaagcagaaa aaatgcaaat acaccaatga aataaaatag ctcagaaact ggtccacttg 141301 gatatataca aacttggtgt agaattggct tcacatatgg cagaaaaaat atactttttt 141361 tattgtaagg taaattgcct cactgtaaag gggataaaat gctaaagcca aatctatatc 141421 tgactttcta ggtagagcac atataaatag atgaggaagg ggatcttcaa atcttatttt 141481 aggaaataat tatgatttgg gtgtgaagaa gggcatcttt gaaatatctc aaaactacaa 141541 accaacaagg tgaggcttgt ggatttgacc ttatcaatat caaggatttt tgatcaacag 141601 agactaccgt tgtcagattt ttgactgaga agaggtttta ctaaagttta aaatcagcaa 141661 tagtttgata cotagataga aggaacttct gtccttgaat caaaatcatg cagaaacaag 141721 gtgtgaaact caatttaaaa agtagtcaaa tgtcacaaaa taagaaaggg aagcccaaac 141781 ggctagcaaa tatgttgaaa tgatcaaact caccagctgt cagagaaatg aaaattaaaa 141841 ataaaacgaa ctatctattg cattacaacc atcattcgga caaaaagtat gaaagtcaaa 141901 aatacttcta actgaagttg tggggaaatt agaacacttg cagagtgtca ttccagacag 141961 cagcttggtg atcctgggtg catgtggggt ctgtctctgg tggccctggg tgcatgtgga 142021 ggtctgtttc tggtggcctc tgatgaatgc ggggtctgtc tctgatggtc ctaggtgaat 142081 gtgggtgttg tctctttctc tggtggtcct gggtggatgt ggggtgtgtc tctgatggtc 142141 ctgagtgaat gtgggtgtct gtcactttct ctagtggccc tgggtggaat atagtagccc 142201 tgtctctatt ggtcttgcat gaaatgtagt gagcttatgt ccactagtcc tgggtgcagt 142261 gtgtttagcc tctacatact catcaactgc tttattataa gtccaggagg gacgctgtcc 142321 agcaggtaag taaggaacac aggtgaaggt atcagtcgtg tggctgcatg tggtagagga 142381 aaagagagca caacctctgt ccatcactat ggtgacagag aagtaaaagg tggatgtatt 142441 ccacggaaca ctcctcaact gttaggaccc ctgagctaga catgtataca acaataccga 142501 taaacctcta aaacaaaatg ctgagcagaa aacccaagta gcaggatttc taatgctcac 142561 taaaacctct atgaacccag aaaccggaaa cacaaaccag cacaatctgt tctgcatgag 142621 cacatgtgtc ttggaggact ggaggacgca ttgccaagca cctaggcatg ggtgtctatg 142681 aggggaagag aaaggcagta ggcacaggag gtttgaagaa aactgatcat ttaaaatatg 142741 aaagatcata aaatcagagc tgtgccctgt aggaatcttg aaaatggtct gccatgaact 142801 taggaatcta attagctcaa aggtcagagt catgatcaag taagataaaa ggggtcagta 142861 cccacggctc attaccctgc tcttaccaaa cactgtgctc tctctgataa aagccacgtc 142921 tccagccccg tctctcagac acctgtgaaa agagaaacca tcaggggtaa gcacaggcag 142981 ccctccccag cccctccctg tggaacagta gccctggcac tcagcatcta tgggtttcta 143041 ctccctgcag ggcagggctc tgaagctt (2) INFORMATION FOR SEQ ID NO:26: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 5133 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single D)TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:26: 1 cctctttcac cctgtctagg ttgccagcaa atcccacggg cctcctgacg ctgcccctgg 61 ggccacaggt ccctcgagtg ctggaaggat gaaggattcc tgcatcactg tgatggccat 121 ggcgctgctg tctgggttct ttttcttcgc gccggcctcg agctacaacc tggacgtgcg 181 gggcgcgcgg agcttctccc caccgcgcgc cgggaggcac tttggatacc gcgtcctgca 241 ggtcggaaac ggggtcatcg tgggagctcc aggggagggg aacagcacag gaagcctcta 301 tcagtgccag tcgggcacag gacactgcct gccagtcacc ctgagaggtt ccaactatac 361 ctccaagtac ttgggaatga ccttggcaac agaccccaca gatggaagca ttttggcctg 421 tgaccctggg ctgtctcgaa cgtgtgacca gaacacctat ctgagtggcc tgtgttacct 481 cttccgccag aatctgcagg gtcccatgct gcaggggcgc cctggttttc aggaatgtat WO 00/09525 PCT/US99/17712 EPI-109 1172 541 caaaggcaac gtaaacctgg tatttctatt zaatggttcg atgagctzgc agccagatga 601 atttcagaaa at- ctggact tcatgaagga tgtgatgaag aaactcauca acacttcgta 661 ccagtttgct gczgttcagt tttccacaaa ctacaaaaCa gaatttaatt tctcagatta 721 tgttaaatgg aaagaccctg atgctctgct gaagcatgta aagcacatgt tgctgttgac 781 caataccttt ggtgccatca attatgtcgc qacagaggtg ttccgggagg agctgggggc 841 ccggccaqat gccaccaaag tgcttatcat catcacggat ggggaggcca ctgacagtgg 901 caacatcgat gcagccaaag acatcatccg ctacatcatc gggattaaaa agcattttca 961 gaccaaggag agtcaggaga ccctccacaa atttgcatca aaacccacga gcgagtttgt 1021 gaaaattctg gacacatttg agaagctgaa agatctattc actgagctgc agaagaagat 1081 ctatgtcatt gagggcacaa gcaaacagga cctgacttcc ttcaacatgg agctgtcctc 1141 cagcggcatc agtgctgacc tcagcagggg ccaigcagtc gtgggggcag taggagccaa 1201 ggactgggct gggggctttc ttgacctgaa ggcagacctg caggatgaca catttattgg 1261 gaatgaacca ttgacaccag aagtgagagc aggctatttg ggttacaccg tgacctggct 1321 gccctcccgg caaaagactt cgttgctggc ctcgggagcc cctcgatacc agcacatggg 1381 ccgagtgctg ctgttccaag agccacaggg cggaggacac tggagccagg tccagacaat 1441 ccatgggacc cagattggct cttatttcgg tggggagctg tgtggcgtcg acgtggacca 1501 agatggggag acagagctgc tgctgattgg tgccccactg ttctatgggg agcagagagg 1561 aggccgggtg tttatctacc agagaagaca gttggggttt gaagaagtCt cagagctgca 1621 gggggacccc ggctacccac tcgggcggtt tggagaagcc atcactgctc tgacagacat 1681 caacggcgat gggctggtag acgtggctgt gggggcccct ctggaggagc agggggctgt 1741 gtacatcttc aatgggaggc acggggggct tagtccccag ccaagtcagc ggatagaagg 1801 gacccaagtg ctctcaggaa ttcagtggtt tggacgctcc atccatgggg tgaaggacct 1861 tgaaggggat ggcttggcag atgtggctgt gggggctgag agccagatga tcgtgztgag 1921 ctcccggccc gtggtggata tggtcaccct gatgtccttc tctccagctg agatcccagt 1981 gcatgaagtg gagtgctcct attcaaccag taacaagatg aaagaaggag ttaatatcac 2041 aatctgtttc cagatcaagt ctctctaccc ccagttccaa ggccgcctag ttgccaatCt 2101 cacttacact ctgcagctgg atggccaccg gaccagaaga cgggggttat tcccaggagg 2161 gagacatgaa ctcagaagga atatagctgt caccaccagc atgtcatgca CtgaCttCtC 2221 atttcatttc ccggtatgtg ttcaagacct catctccccc atcaatgttt ccctgaattt 2281 ctctctttgg gaggaggaag ggacaccgag ggaccaaagg gcgcagggca aggacatacc 2341 gcccatcctg agaccctccc tgcactcgga aacctgggag atcccttttg agaagaactg 2401 tggggaggac aagaagtgtg aggcaaactt gagagtgtcc ttctctcctg caagatccag 2461 agccctgcgt ctaactgctt ttgccagcct ctctgtggag ctgagcctga gtaacttgga 2521 agaagatgct tactgggtcc agctggacct gcacttcccc ccgggactct ccttccgcaa 2581 ggtggagatg ctgaagcccc atagccagat acctgtgagc tgcgaggagC ttcctgaaga 2641 gtccaggctt ctgtccaggg cattatcttg caatgtgagc tctcccatct tcaaagcagg 2701 ccactcggtt gctctgcaga tgatgtttaa tacactggta aacagctcct ggggggactc 2761 ggttgaattg cacgccaatg tgacctgtaa caatgaggac tcagacctcc tggaggacaa 2821 ctcagccact accatcatcc ccatcctgta ccccatcaac atcctcatcc aggaccaaga 2881 agactccaca ctctatgtca gtttcacccc caaaggccCC aagatccacc aagtcaagca 2941 catgtaccag gtgaggatcc agccttccat ccacgaccac aacataccca ccctggaggc 3001 tgtggttggg gtgccacagc ctcccagcga ggggcccatc acacaccagt ggagcgtgca 3061 gatggagcct cccgtgccct gccactatga ggatctggag aggctcccgg atgcagctga 3121 gccttgtctc cccggagccc tgttccgctg ccctgttgtc ttcaggcagg agatcctcgt 3181 ccaagtgatc gggactctgg agctggtggg agagatcgag gcctcttcca tgttcagcct 3241 ctgcagctcc ctctccatct ccttcaacag cagcaagcat ttccacctct atggcagcaa 3301 cgcctccctg gcccaggttg tcatgaaggt tgacgtggtg tatgagaagc agatgctcta 3361 cctctacgtg ctgagcggca tcggggggct gctgctgctg ctgctcattt tcatagtgct 3421 gtacaaggtt ggtttcttca aacggaacct gaaggagaag atggaggctg gcagaggtgt 3481 cccgaatgga atccctgcag aagactctga gcagctggca tctgggcaag aggctgggga 3541 tcccggctgc ctgaagcccc tccatgagaa ggactctgag agtggtggtg gcaaggactg 3601 agtccaggcc tgtgaggtgc agagtgccca gaactggact caggatgccc agggccactc 3661 tgcctctgcc tgcattctgc cgtgtgccct cgggcgagtc actgcctctc cctggccctc 3721 agtttcccta tctcgaacat ggaactcatt cctgaatgtc tcctttgcag gctcataggg 3781 aagacctgct gagggaccag ccaagagggc tgcaaaagtg agggcttgtc attaccagac 3841 ggttcaccag cctctcttgg ttccttcctt ggaagagaat gtctgatcta aatgtggaga 3901 aactgtagtc tcaggaccta gggatgttCt ggccctcacc cctgccctgg gatgtccaca 3961 gatgcctcca ccccccagaa cctgtccttg cacactcccc tgcactggag tccagtctct 4021 tctgctggca gaaagcaaat gtgacctgtg tcactacgtg actgtggcac acgccttgtt 4081 cttggccaaa gaccaaattc cttggcatgc cttccagcac cctgcaaaat gagaccctcg 4141 tggccttccc cagcctcttc tagagccgtg atgcctccct gttgaagctc tggtgacacc 4201 agcctttctc ccaggccagg ctccttcctg tcttcctgca ttcacccaga cagctccctc 4261 tgcctgaacc ttccatctcg cccacccctc cttccttgac cagcagatCC cagctcacgt 4321 cacacacttg gttgggtcct cacatctttc acacttccac caccctgcac tactcccica 4381 aagcacacgt catgtttctt catccggcag cctggatgtt ttttccctgt ttaatgattg 4441 acgtacttag cagctat-ctc tcagtgaact gtgagggtaa aggctatact t-atcttgttc 4501 accttgggat aacgCCucat gatatgtcag ggcgtgggac atctagtagg tgcttgacat 4561 aatttcactg aactaatuac agagccagtg ggaagataca gaaaaagagg gccggggctg WO 00/09525 PCT/US99/17712 EPI-I09 1173 4621 ggcacggtgg ::cacgcc:g taatcccaac actttgggag gccaaggagg gtggatcacc 4681 tgaggtcaag aattaaaggc cagcctggcg aaaccccatc tctactaaaa atacaaaatc 4741 cagacgtggt aacacacace tgtagtccca gctactcagg aggttgaggt aggagaattg 4801 cttgaacctg ggaggtggag gttgcagtga gccaaaattg cgccattgca ctccagcctg 4861 ggcaacacag cgagactccg tctcaaggaa aaaataaaaa taaaaagcgg gcacgggccc 4921 ggacatcccc acccttagag gctgtcttct caggctctgc cctgccctag ctccacaccc 4981 tctcccagga cccatcacac ctgtgcagtg gcccccacag aaagactgag ctcaaggtgg 5041 gaaccacgtc tgctaacttg gagccccagt gccaagcaca gtgcctgcat gtatttatcc 5101 aataaatgtg aaattctgtc caaaaaaaaa aaa (2) INFORMATION FOR SEQ ID NO:27: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1388 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:27: 1 ggatccagaa gggtcattca atcagttctc agtcttatca ggtctaagtt cctttcttat 61 caggtcctaa aggcctaatc ttatcattgt gacaaagata actgtagagt ctgttaaact 121 ttttttttaa taacatgaag attatgattt atagctgaat ttctcccttt tattccaatt 181 caacaatttt catggctttt tgtgtttgtt ttgttctgga catatttaca gaaaattacc 241 tgaagagttc caacctgagg cctcctcatg gatgggtcaa acgtgacatc atttgttgtt 301 gaggaaccca cgaacatctc aactggcagg aacgcctcag tcgggaatgc acatcggcaa 361 atccccatcg tgcactgggt cattatgagc atctccccag tggggtttgt tgagaatggg 421 attctcctct ggttcctgtg cttccggatg agaagaaatc ccttcactgt ctacatcacc 481 cacctgtcta tcgcagacat ctcactgctc ttctgtatit tcatcttgtc tategactat 541 gctttagatt atgagctttc ttctggccat tactacacaa ttgtcacatt atcagtgact 601 tttctgtttg gctacaacac gggcctctat ctgctgacgg ccattagtgt ggagaggtgc 661 ctgtcagtcc tttaccccat ctggtaccga tgccatcgcc ccaagtacca gtcggcattg 721 gtctgtgccc ttctgtgggc tctttcttgc ttggtgacca ccatggagta tgtcatgtgc 781 atcgacagag aagaagagag tcactctcgg aatgactacc gagcagtCat catctttata 841 gccatcctga gcttcctggt cttcacgcc ctcatgctgg tgtccagcac catcttggtc 901 gtgaagatcc ggaagaacac gtgggcttcc cattcctcca agctttacat agtcatcatg 961 gtcaccatca ttatattcct catcttcgct atgcccatga gactccttta cctgctgtac 1021 tatgagtatt ggtcgacctt tgggaaccta caccacattt ccctgctctt ctccacaatc 1081 aacagtagcg ccaacccttt catttacttc tttgtgggaa gcagtaagaa gaagagattc 1141 aaggagtcct taaaagttgt tctgaccagg gctttcaaag atgaaatgca acctcggcgc 1201 cagaaagaca attgtaatac ggtcacagtt gagactgtcg tctaagaact gtgagggaag 1261 ttgtggataa aaatggtgga acacaggtca tttttagttt gtgcttggaa tatgacttaa 1321 gtatctccta aatgtgatac agaagaacat ctcatcaat atgcatgaga tactaattaa 1381 tgatgaaa (2) INFORMATION FOR SEQ ID NO:28: Ci) SEQUENCE CHARACTERISTICS: (A) LENGTH: 393 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:28: 1 gagcagtgcc cagcttgtcg cagatattga agccgtgtaa aataaatgcc tttgattgtt 61 cacactttaa gcaatattgg tacaatatta aacccattgt cccaggcact ccctctcctt 121 actgcttatg gcacttcatg tattaaaaaa tgacagtggc agcattgccc agacatgcgt 181 tttgtcatca agtcttaatg cagtccacct ggtccctcag gcaaatgaat ggaggcacag 241 aagatgaaat gattttcaaa atgccattag gaaagctcag gccagaactg gaaatgggtc 301 ccgcacaggg cactcggcca ctcttgcctg gccatctcct ttttggcact aagcacacaa 361 tgatatagaa tgaatggtta tcactgggga tcc (2) INFORMATION FOR SEQ ID NO:29: (i) SEQUENCE CHARACTERISTICS: CA) LENGTH: 1388 base pairs (B) TYPE: nucleic acid (C) STRAI4DEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:29: 1 ggatccagaa gggtcattca atcagttctc agtcttatca ggtctaagtt cctttcttat 61 caggtcctaa aggcctaatc ttatcattgt gacaaagata actgtagagt gttaaact 121 ttttttttaa taacatgaaa attatgattt atagctgaat ttctcccttt tattccaatt 181 caacaatttz catqgctttt tgtgtttgtt ttgtctga catattiaca aaaaattac 241 tqaagagttc caacctgagg cctctata gatttttcaa acgtgacazc azttgttgtt 301 gaggaaccca cgaacatctc aacggcaga aacgtcag tcgggaatac acatcggcaa WO 00/09525 PCT/US99/17712 EPI-109 1174 361 atccccatcg cgcactgggt cattataagc atctccccag tggggttzgt tgagaatagg 421 attctcctct ggttcctatg cttccggatg agaagaaatc cottcactgt ctacatcacc 481 cacctgtcta tcgcagacat ctcactgctc ttctgtattt tcatcttgtc tatcgactat 541 gctttagatt atgagctttc ttctggccat tactacacaa ttgtcacatt atcagtgact 601 tttctgtttg gctacaacac gggcctctat ctgctgacgg ccattagtgt ggagaggtgc 661 ctgtcagtcc tttaccccat ctggtaccga tgccatcgcc ccaagtacca gtcggcatta 721 gtctgtgccc ttctgtgggc tctttcttgc ttggtgacca ccatggagta tgtcatgtgc 781 atcgacagag aagaagagag tcactctcgg aatgactgcc gagcagtcat catctttata 841 gccatcctga gcttcctggt cttcacgccc ctcatgctgg tgtccagcac catcttggtc 901 gtgaagatcc ggaagaacac gtgggcttcc cattcctcca agctttacat agtcatcatg 961 gtcaccatca ttatattcct catcttcgct atgcccatga gactccttta cctgctgtac 1021 tatgagtatt ggtcgacctt tgggaaccta caccacattt ccctgctctt ctccacaatc 1081 aacagtagcg ccaacccttt catttacttc tttgtgggaa gcagtaagaa gaagagattc 1141 aaggagtcct taaaagttgt tctgaccagg gctttcaaag atgaaatgca acctcggcgc 1201 cagaaagaca attgtaatac ggtcacagtt gagactgtcg tctaagaact gtgagggaag 1261 ttgtggataa aaatggtgga acacaggtca tttttagttt gtgcttggaa tatgacttaa 1321 gtatctccta aatgtgatac agaagaacat ctcatcccat atgcatgaga tactaattaa 1381 tgatgaaa (2) INFORMATION FOR SEQ ID NO:30: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 3169 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:30: 1 ggatccagaa gggtcattca atcagttctc agtcttatca ggtctaagtt cctttcttat 61 caggtcctaa aggcctaatc ttatcattgt gacaaagata actgtagagt ctgttaaact 121 ttttttttaa taacatgaag attatgattt atagctgaat ttctcccttt tattccaatt 181 caacaatttt catggctttt tgtgtttgtt ttgttctgga catatttaca gaaaattacc 241 tgaagagttc caacctgagg cctcctcatg gatgggtcaa acgtgacatc atttgttgtt 301 gaggaaccca cgaacatctc aactggcagg aacgcctcag tcgggaatgc acatcggcaa 361 atccccatcg tgcactgggt cattatgagc atctccccag tggggtttgt tgagaatggg 421 attctcctct ggttcctgtg cttccggatg agaagaaatc ccttcactgt ctacatcacc 481 cacctgtcta tcgcagacat ctcactgctc ttctgtattt tcatcttgtc tatcgactat 541 gctttagatt atgagctttc ttctggccat tactacacaa ttgtcacatt atcagtgact 601 tttctgtttg gctacaacac gggcctctat ctgctgacgg ccattagtgt ggagaggtgc 661 ctgtcagtcc tttaccccat ctggtaccga tgccatcgcc ccaagtacca gtcggcattg 721 gtctgtgccc ttctgtgggc tctttcttgc ttggtgacca ccatggagta tgtcatgtgc 781 atcgacagag aagaagagag tcactctcgg aatgactgcc gagcagtcat catctttata 841 gccatcctga gcttcctggt cttcacgccc ctcatgctgg tgtccagcac catcttggtc 901 gtgaagatcc ggaagaacac gtgggcttcc cattcctcca agctttacat agtcatcatg 961 gtcaccatca ttatattcct catcttcgct atgcccatga gactccttta cctgctgtac 1021 tatgagtatt ggtcgacctt tgggaaccta caccacattt ccctgctctt ctccacaatc 1081 aacagtagcg ccaacccttt catttacttc tttgtgggaa gcagtaagaa gaagagattc 1141 aaggagtcct taaaagttgt tctgaccagg gctttcaaag atgaaatgca acctcggcgc 1201 cagaaagaca attgtaatac ggtcacagtt gagactgtcg tctaagaact gtgagggaag 1261 ttgtggataa aaatggtgga acacaggtca tttttagttt gtgcttggaa tatgacttaa 1321 gtatctccta aatgtgatac agaagaacat ctcatcccat atgcatgaga tactaattaa 1381 tgatgaaa 1 gagcagtgcc cagcttgtcg cagatattga agccgtgtaa aataaatgcc tttgattgtt 61 cacactttaa gcaatattgg tacaatatta aacccattgt cccaggcact ccctctcctt 121 actgcttatg gcacttcatg tattaaaaaa tgacagtggc agcattgccc agacatgcgt 181 tttgtcatca agtcttaatg cagtccacct ggtccctcag gcaaatgaat ggaggcacag 241 aagatgaaat gattttcaaa atgccattag gaaagctcag gccagaactg gaaatgggtc 301 ccgcacaggg cactcggcca ctcttgcctg gccatctcct ttttggcact aagcacacaa 361 tgatatagaa tgaatggtta tcactgggga tcc 1 ggatccagaa gggtcattca atcagttctc agtcttatca ggtctaagtt cctttcttat 61 caggtcctaa aggcctaatc ttatcattgt gacaaagata actgtagagt ctgttaaact 121 ttttttttaa taacatgaag attatgattt atagctgaat ttctcccttt tattccaatt 181 caacaatttt catggctttt tgtgtttgtt ttgttctgga catatttaca gaaaattacc 241 tgaagagttc caacctgagg cctcctcatg gatgggtcaa acgtgacatc atttgttgtt 301 gaggaaccca cgaacatctc aactggcagg aacgcctcag tcgggaatgc acatcggcaa 361 atccccatcg tgcactgggt cattatgagc atctccccag tggggtttgt tgagaatggg 421 attctcctct ggttcctgtg cttccggatg agaagaaatc ccttcactgt ctacatcacc 481 cacctgtcta tcgcagacat ctcactgctc ttctgtattt tcatcttgtc tatcgactat 541 gctttagatt atgagctttc ttctggccat tactacacaa ttgtcacatt atcagtgact 601 tttctgtttg gctacaacac gggcctctat ctgctgacgg ccattagtgt ggagaggtgc 661 ctgtcagtcc tttaccccat ctggtaccga tgccatcgcc ccaagtacca gtcggcattg WO 00/09525 PCT/US99/17712 EPI-109 1175 721 gtcgtgccc ttctgtgggc tctttcttgc ttggtgacca ccacggagta tgtcatgtgc 781 atcgacagag aagaagagag rcactctcgg aatgactgcc gagcagtcat catctttata 841 gccatcctga gcttcctggt cttcacgccc ctcatgctgg tgtccagacac catcttggtc 901 gtgaagatcc ggaagaacac gtgggcttcc cattcctcca agctttacat agtcatcatg 961 gtcaccatca ttatattcct catcttcgct atgcccatga gactccttta cctgctgtac 1021 tatgagtatt agtcgacctt tgggaaccta caccacattt ccctgctctt ctccacaatc 1081 aacagtagcg ccaacccttt catttacttc tttgtgggaa gcagtaagaa gaagagattc 1141 aaggagtcct taaaagttgt tctgaccagg gctttcaaag atgaaatuca acctcggcgc 1201 cagaaagaca attgtaatac ggtcacagtt gagactgtcg tctaagaact gtgagggaag 1261 ttgtggataa aaatggtgga acacaggtca tttttagttt gtgcttggaa tatgacttaa 1321 gtatctccta aatgtgatac agaagaacac ctcatcccat atgcatgaga tactaattaa 1381 tgatgaaa (2) INFORMATION FOR SEQ ID NO:31: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 3585 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:31: 1 gggcccagag aaagagctgt ccccggggcc ttggggacag ggtgacagcc acccagagat 61 catggagaag gggacgtaag gaagacctca cagaggagtc atcctgcgac tgtgttggtt 121 gggtccttca ggaagcagag tcccaggagt tggaagcata agaggaatac tgcgggcaat 181 gcctgagaaa gataacaggg accgggagca ggagtgagtt gggcagggga aggatcaggc 241 ccacaatgcc aggctcacac ctgcagagga gggaagaaga agaagggcct cacatcagcc 301 cagcggggga tgttacgccc acagacgccc cgggqctcag ttactgtcta agtgttagaa 361 ataaattttc ggtgccacaa aagaaatagc actcagatta aatgttccca gcaaggcaat 421 tttacttcta tagaagggtg catctcacag atggagcaat ggcaagagca cacctgaaca 481 agggaaggga aggggttttt atccctaagg caggtagccc ctacagctgt gttgttcccc 541 tattggctag ggttggacca caccgtctga gctaattgtt actggctatt ttaaagagag 601 caggggtaag agccggattg gcagggtaag tagtttggca ggaaggacgg tcacagaaca 661 ggtgactcag gatgactcag gtcagagcag gtgaccagtg gtgactcagt tcggagcagg 721 tgatagaagc taggaggggg ttgtttactg aaactagggg caaggagacg aagagaacat 781 gaaagttaaa ctttaagatg aagaacaaag ctgaacatac tgatgcattg gatctttgga 841 gaggatctca gaactcattg tacttaattt acaggctaaa accttagaag aggaatttat 901 tatatcctac acaagactcc agggaagcac atggccttgg actgaaggct ggcatctgga 961 agctgtcagc caccagcacc ttctgcagca ggtacctgct ctctaagagg gaggcctggg 1021 tggtgcacct ccagagctgc ccaggctggg cctcaaggaa gaaaaagatt ttcatttgtc 1081 agaggcggaa gggagaggtg gagggaacag cacagcagcg gcccaggggc agggaagcac 1141 aggaccatta gggagacacg agaaagccca tttgtctaga acagaggatt caagcagtgc 1201 accaaggaaa atgagggcca ggccaatgtg ctggagtggc tttgttcttg gctgagggtt 1261 ttgggtagtg ccaaagcgta aggtaagccc tgctttccag aagaatctag cagagtgtgg 1321 agcccagatg ggactggaag gcctgggagg ggtcaggtgg ccacagggac gggccacagc 1381 cagtggtgca ggcaagaaga caatggccat ccatggtggc tcacacctgg aatcccagcc 1441 cattgggagg tcgaggcagg tggatcacct gaggtcagga gttcgagacc agcctggtca 1501 acatggtgaa accctgtctc taataaaatt ataaaaatta gccgggcgtg gtggtgggta 1561 cctgtaatct cagctactca ggaggctggg tcaggagaat cgcttgaacc caggaggcgg 1621 aggttacagt gagctgagat agcaccattg cattccagcc tggacaacaa aagcgagact 1681 ctgtctcaaa aaaaaaaaaa aattagccag gcgtggtggt gggtgcctgt cgtcctcggg 1741 aggctgaggc atgagaatca ctccgggagg cagaggttgc aatgaaccaa gatcacacca 1801 ctgcactcca gcctgggtga cagagcaaga ctctgtctaa aaaaaaaaaa aagacagaag 1861 gatgtcagca tctgatgctg cctgtcacct tgaccctgag gatgccagtc acagctccat 1921 taactgggac ctaggaaaat gagtcatcct tggtcatgca catttcaaat ggtggcttaa 1981 tatggaagcc acacttggga tctgttgtct cctccagcat ggtagaagat gcctgaaaag 2041 taggggctgg atcccatccc ctgcctcact gggaaggcga ggtggtgggg tggggtgggg 2101 cctcaggctt ggggtcatgg gacaaagccc aggctgaatg ccgcccttcc atctccctcc 2161 tcctgagaca ggggcagcag ggcacactag tgtccaggag cagcttatga ggccccttca 2221 ccctccgatc ctccaaaact ggcagacccc accttcttcg gtgtgacccc agagctctga 2281 gqacagcccg ttccttccgc ctgccggccc cccacccagg cccaccccaa ccttatcctc 2341 cactgctttt cagaggagtc tggccaacac aaatcctctt gtttgtttgt ctgtctgtct 2401 gctgctccta gtctctgcct ctcccagtct ctcagcttcc gtttctttct taaactttct 2461 ctcagtctct gaggtctcga aatcacgagg cttcgacccc tgtggaccag atgcccagct 2521 agtggccttt ctccagcccc tcagatggca cagaactaca aaccccagca tgcactctgg 2581 cctgaagtgc ctggagagtg ctggtgtacc ccacctgcat tctgggaact gtagtttccc 2641 tagtccccca tgctcccacc agggcatcaa gctcttccct ggccggctga ccctgcctca 2701 gccctagtct ctctgctgac ctgcggcccc gggaagcgtg cgtcactgaa tgacagggtg 2761 ggggtggagg cactggaagg caucttcctg ctcttttgtg tcccccactt gagtcatggg 2821 ggtgtggggg ttccaggaaa ttggggctgg gaggggaagg gataccctaa tgtcagacc 2881 aaggacaaaa agtcactaca tccttgctgg gcctctatcc ccaagaaccc aaaaggactc WO 00/09525 PCT/US99/17712 EPI-109 1176 2941 aagggtgggg atccaggagt tcttgtatgt atggggggag gtgaaggaga gaacctgcat 3001 gaccctagag gtccctgtgg tcactgagag tgtgggctgc catcccctgc tacagaaacg 3061 gtgctcacct tctgcccaac cctccaggga aaggcacaca ggggtgaggc cgaaccttcc 3121 gtctggtgcc acatcacaga aggaccttta tgaccccctg gtggctctac cctgccactc 3181 cccaatgccc cagcccccat gctgcagccc cagggctctg ctggacacct gggctcccac 3241 ttatcagcct cagtcctcac agcggaaccc aggcgtccgg ccccccaccc ttcaggccag 3301 cgggcgtgga gctgaggctt tagagcctcc cagccgggct tgttcctgtc ccattgtgta 3361 tgggataggg gcggggcgag ggccagcact ggagagcccc ctcccactgc cccctcctct 3421 cggtcccctc cctcttccta aggaaaaggc cagggctctg ctggagcagg cagcagagtg 3481 gacgcacagt aacatgggca acttgaagag cgtggcccag gagcctgggc caccctgcgg 3541 cctggggctg gggctgggcc ttgggctgtg cggcaagcag ggccc (2) INFORMATION FOR SEQ ID NO:32: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 23142 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:32: 1 ggatcccatg ccctgcctca ctgggaaggc gaggtggtgg ggtggggtgg ggcctcaggc 61 ttggggtcat gggacaaagc ccaggctgaa tgccgccctt ccatctccct cctcctgaga 121 caggggcagc agggcacact agtgtgcagg agcagcttat gaggcccctt caccctccat 181 cctccaaaac tggcagaccc caccttcttg gtgtgacccc agagctctga gcacagcccg 241 ttccttccgc ctgccggccc cccacccagg cccaccccaa ccttatcctc cactgctttt 301 cagaggagtc tggccaacac aaatcctctt gtttgtttgt ctgtctgtct gctgctccta 361 gtctctgcct ctcccagtct ctgagcttcc gtttctttct taaactttct ctcagtctct 421 gaggtctcga aatcacgagg cttcgacccc tgtggaccag atgcccagct agtggccttt 481 ctccagcccc tcagatgaca cagaactaca aaccccagca tgcactctgg cctgaagtgc 541 ctggagagtg ctggtgtacc ccacctgcat tctgggaact gtagtttccc tagtccccca 601 tgctcccacc agggcatcaa gctcttccct ggctggctga ccctgcctca gccctagtct 661 ctctgctgac tgcggccccg ggaagcgtgc gtcactgaat gacagggtgg gggtggaggc 721 actggaaggc agcttcctgc tcttttgtgt cccccacttg agtcatgggg gtgtgggggt 781 tccaggaaat tggggctggg aggggaaggg ataccctaat gtcagactca aggacaaaaa 841 gtcactacat ccttgctggg cctctatccc caagaaccca aaaggactca agggtgggga 901 tccaggagtt cttgtatgta tggggggagg tgaaggagag aacctgcatg accctagagg 961 tccctgtggt cactgagagt gtgggctgcc atcccctgct acagaaacgg tgctcacctt 1021 ctgcccaacc ctccagggaa aggcacacag gggtgagccg aaggcccttc cgtctggtgc 1081 cacatcacag aaggaccttt atgaccccct ggtggctcta ccctgccact ccccaatgcc 1141 ccagccccca tgctgcagcc ccagggctct gctggacacc tgggctccca cttatcagcc 1201 tcagtcctca cagcggaacc caggcgtccg gccccccacc cttcaggcca gcgggcgtgg 1261 agctgaggct ttagagcctc ccagccgggc ttgttcctgt cccattgtgt atgggatagg 1321 ggcggggcga gggccagcac tggagagccc cctcccactg ccccctcctc tcggtcccct 1381 ccctcttcct aaggaaaagg ccagggctct gctggagcag gcagcagagt ggacgcacag 1441 taacatgggc aacttgaaga gcgtggccca ggagcctggg ccaccctgcg gcctggggct 1501 ggggctgggc cttgggctgt gcggcaagca gggcccagcc accccggccc ctgagcccag 1561 ccgggcccca gcatccctac tcccaccagc gccagaacac aggtaagggc caggcagcta 1621 ggagcaggtg ggcaacaagg gtggtgtcaa ggcctgaagc ctggggctgg gaaggtctgg 1681 aacttgtagc tgagtcggga gggccaggtc acaaatgcaa aagggctatt aatgtgcata 1741 gaacaggaca gtctgggagg ctcagaaagg agaccaggat cagagtcggc aggtgaagct 1801 gggagtaagg gtgccagcta tagaatctgg ccagggtttg aatgctgctc tgccgccagg 1861 agctgtttga ctttgagcaa gttacttaat ctctctgaac ctccatttat ataaaacgag 1921 atatggcaat acttactcca tggggaagta agtttctagc tcacagcaag ccttcaacag 1981 cagcgatgat tatttagctg gagaagaaag gagctgacag cagtggttac aggagtgaga 2041 aagtggggtc tcccagaaga gggagagagt tgggcaggaa actcgggccc ttggggtaag 2101 caggctgaga agacagagcc accaggcttt tttcccctgc tccagccccc tctcctcgtg 2161 gctgtcaccc gaaaactgga ccatgcagtt cccacaagag tcctcccggg ggtagaggtc 2221 ccaggaggga ggaaagaccc ggaggcctgg tggggtgcca ggccgggggc aggctggggc 2281 tgcaggcagc tatgcaggga aggctgaggg ccggggccct gctgctcagg cgcacccttg 2341 gcctgagtcc ctcccttcct ccctgccgct ggtggctctg ggaggaagtg ataaggcctg 2401 cgaggcttcc cttcacacat ggggctgctg tcaggagggg ttgtgagtgc ggagggaaat 2461 cagagctgag gaatccctgc agggcttccc tccactcaag caccaggctc tgtccccctc 2521 agggtagggc ttatagcagc tttgcggggg gtggacaccc catctccaga agaggtgagg 2581 tgggcgctgc aggtgggatg cgaacttagc ctcgggtcag gggctcagga gctcagcacc 2641 agcagcccct gcagcccagg accctggtct ataaacggag gcacagctcg cctctagctc 2701 ctaaggcatg gggaacgcca gaaggcatgc ggcaggtggg ctgtgagatc gccagtgctg 2761 taacaggggc ctccgggtga catctgggaa ggctgaaagg aaacaaaccc ttcctgatga 2821 ccctatccct ggctcccaac agccccccga gctccccgct aacccagccc ccagaggggc 2881 ccaagttccc tcgtgtgaag aactgggagg tggggagcat cacctatgac accctcagcg 2941 cccaggcgca gcaggtaagg ccggcatgcc ctgtccccat cgtctccagg gaaagggtgg WO 00/09525 PCT/US99/17712 EPI-109 7177 3001 graaggcctg gcctcagatg gggccggaga aggaagctca acccttcttt gaattggtcc 3061 cttgtttcca aaaagaggag aggactggga agaaccagag gaattgaggg acatgcacgg 3121 gacttgggtg accctcagcc tccagcctta cccccaaccc tggctcaaac ttttccccca 3181 tcccacccct gcaccccttt tccccctccc acccctgcac ccttcctccc tctcccccac 3241 cccacccctg ccCcccctcc catcccagct ctaaacccct cctccctctc cccCgtccca 3301 cccctaaacc ccacctccct gtccccctct aaacccctcc tccctgtccc cctctaaacc 3361 ccacctccct ctccccatcc cacccctgca cccttcctcc ctctgccccc gtcccacgcc 3421 tgtactcctc ctccctctcc cccgtcacac ccctgcaccc ctcctccctc tccccatccc 3481 atccctgcac ccctcctccc tctgcccccg tcccacccct aaacccctcc tccctctgcc 3541 ccaccccacc cttgcacccc rcctccctct tcccccgtcc cctgcctgca ttcctcct c c 3601 ctctccccat ctcacccctg cacccctctt ccctctccca cccctgcacc cctcctccct 3661 ctccccgtcc caccctgcac tcccgccctc tccagcgtcc cacccctaca cccctcctcc 3721 ctctgcccca ttccacccct gcaccccctc ctccctctgc cccgacccac ccctgcaccc 3781 ctcctccctc tcccccgtcc cacccctgca tccctcctcc ctctgccccg tcccacccct 3841 acacccctcc tccctctccc ccatcccacc cctaaacccc tcctccctct cccctgtccc 3901 atccctgcac ccttcctccc tctccccgtc ccatccctgc acccttcctc cctctccccg 3961 tcccatccct gcacccctcc tccctctgct cccatcccac ccctgcaccc ctcctccctc 4021 tgcccctacc ccacctctgc acccctcctc cttctcccca tcccacccct gcacccctcc 4081 tccctctgcc cctaccccac ccctgcaccc ctcctccttc tccccatccc acctctgcac 4141 ccctcctccc tctcccctct cccacccctg tacccttcct ccttctcccc gtcccacccc 4201 tgcacttctc ctccctctaa cccatcccac ccctgcaccc ttcttccctc tcccccatcc 4261 caccactgca cccctcctcc ctctccccct gttccacccc tgcacccctc ctccctgccc 4321 ccaactccca tcccacccct gcaccctggc ctgtcctgac ctttgcactc cctcgaccca 4381 ggatgggccc tgcaccccaa gacgctgcct gggctccctg gtatttccac ggaaactaca 4441 gggccggccc tcccccggcc ccccggcccc tgagcagctg ctgagtcagg cccgggactt 4501 catcaaccag tactacagct ccattaagag gtgacagctt cccggacgcc acagcctccc 4561 ttgtcccact gaggccccag aaaccccgtg acgaccttcc catgaccccc tcccttccca 4621 gatcctaaca ccacgtgggc ccctcccgcc ctcccccagc acttgcacaa agcctggagg 4681 agggcctccc tgtcccacac aacttcctgc ttgtcccctt cccacccctc tcctccccag 4741 gagcggctcc caggcccacg aacagcggct tcaagaggtg gaagccgagg tggcagccac 4801 aggcacctac cagcttaggg agagcgagct ggtgttcggg gctaagcagg cctggcgcaa 4861 cgctccccgc tgcgtgggcc ggatccagtg ggggaagctg caggtgcggc tggccagcga 4921 ctgagagacc cgggcgctac caaaagggga gcggggtggc ggggcagttc ctaaggcttc 4981 ccgggggctg ggaggtccca aactgtgggg gagatccttg ccttttccct tagagactgg 5041 aaaggtaggg ggactgcccc accctcagca cccaggggaa cctcagccca gtagtgaaga 5101 cctggttatc aggccctatg gtagtgcctt ggctggagga ggggaaagaa gtctagacct 5161 gctgcagggg tgaggaagtc tagacctgct gcaggggtga ggaagtctag acctgctgca 5221 ggggtgagga agtctagacc tgctgcgggg gtgaggaagt ctagacctgc tgcgggggtg 5281 aggacagctg agcggagttc cctgggcggt gctgtcagta gcaggagcag cctcctggaa 5341 aagccctggc tgctgcttct cccccaagag agaaggcttc tcccgccagg ccagtccagt 5401 gcagcccctc acccacaccc actgctaccc cagttcccct gcttcggccc gcaccctccc 5461 tcacacccca gcccacagac tcggggctgg ccttagttac tggaacgcct gtgaccacag 5521 cactaagaga agcaagctgc cccatggggg acttggtccc catggccttg gcctccttca 5581 ccatcactgg ccgccaaaga gtttgaaata aagccacgtg cccagtgaat cccaaaggaa 5641 cctcaactaa aataaaaaca atcctatctg acacttgcct gaccctctaa gtcattcaaa 5701 gctttagctc aacttcgatc catctgagct gccatagtgg accccactca gagctgcgtc 5761 cctcccttga ccccaggttg gtccctgcca ctcccctgcc cctgtcactg acacatgttt 5821 cctcctccct caggcaggag tgggacctcc cagcctcctc ctggggcctc cactcagaat 5881 gtcaggatga gcagggtcct aggaggcctc tggtgcagcc ttcccttccc accatccatg 5941 tgctcaaaga gaatcacccg tcctttcttg aatgccatgg atcatggggg atttgctgcc 6001 cacactccta ggcggcctct tagacatccg ttggtgccta acccaagcat cagtttggca 6061 gaggccgagt ccctcctctg tactggatac caagtcagct tccataggga tggggagaca 6121 cctggcccag ggaggagatg agaagcagcc cggatggtgc tacatatgtc agagagcagg 6181 gcaggaaggg atcagtgtgg ctgccaatgg tcaggagggc gccatggagt gaaccatggc 6241 ccctgcctcc tcaaccaaga agtcctctgg agctgatact caagaccccc cgtctctctc 6301 ctcaccctcc tctcccgctg cctcggctgg ctcaggtgtt cgatgcccgg gactgcaggt 6361 ctgcacagga aatgttcacc tacatctgca accacatcaa gtatgccacc aaccggggca 6421 accttcggtg agtgcccccc accatgccag gccccagcct tcttccccaa ggcagggaag 6481 gcggggctct gaccagctct ttccccatgc gtgccagctc ggccatcaca gtgttcccgc 6541 agcgctgccc tggccgagga gacttccgaa tctggaacag ccagctggtg cgctacgcgg 6601 gctaccggca gcaggacggc tctgtgcggg gggacccagc caacgtggag atcaccgagg 6661 tgggcaccga gggccaccca tgagggtgtc cccaaggtgg agaatgagga aaccagtggg 6721 agaaggctcg ggggatccag gcaggaagag gggagcctcg gtgagataaa ggatgaaaaa 6781 caccaaagga ggggtgcctg ggtggtcacg gagacccagc caatgaggga ccctggagat 6841 gaaggcagga gacagtggat ggaggggtcc ctgaggaggg catgaggctc agccccagaa 6901 ccccctctgg cccactcccc acagctctgc attcagcacg gctggacccc aggaaacggt 6961 cgcttcgacg tgctgcccct gctgctgcag gccccagatg agcccccaga actcttcctt 7021 ctgccccccg agctggtcct tgaggtgccc ctggagcacc ccacgtgagc accaaaggga WO 00/09525 PCT/US99/17712 EPI-109 1178 7081 ttgactgggt gggatggaag gggccatccc tgagcctctc aagaaaggcc tgcaaggggg 7141 tgctgatccc acaccccaac acccccaggc tggagtggtt tgcagccctg ggcctgcgct 7201 ggtacgccct cccggcagtg tccaacatgc tgctggaaat tgggggcctg gagttccccg 7261 cagccccctt cagtggctgg tacatgagca ctgagatcgg cacgaggaac ctgtgtgacc 7321 ctcaccgcta caacatcctg gaggtgaggt gcgggatggg gctcgggcac cgaatgcacc 7381 tgtccaaggc aggagtctgg ctctcactcc atccccaaaa tgccagccac ggggacaatc 7441 agagcaggtc cagggttgcc tcctaaatgg gaactgagga caagctctag aaccactgaa 7501 gcaaaggggt agggggtggc aggggtgtgt gtgggggtgt gagtgggtga gtgtgagagt 7561 gtgggtttct ggggtgtgca gtgggtgaga gtgtgggctt gtggggtgtg tagtgggtgt 7621 gagactgtgg gtttgtaggg gtgggtgagt gtgggtgtgt gggggtaggt gggtgtgggt 7681 ttgtgggtgt gtataggcag tgactgtgag actgtgggtt tgtgggggta ggtgactgtg 7741 ggtttgtggg gtgtgtaggg gtgagtgtgt gtgggtttgt aggggtaggc gagtgtgggt 7801 ttgtggggtg tgtaggggtg agtgtgtgtg agtttgtagg ggtaggcgag tgtgggtttg 7861 tggggtgtgt aggggtgagt gtgtgtgagt ttgtaggggt aggrgagigt gggtttgtgg 7921 ggtgtgtagg gggtgtgtgt gggcttgtag gggtaggcga gtgtgggttt gtggggtgtg 7981 taggggcgag tgtgagagtg taggtatgtg ggtgtgagtg tggatgtgtg taggcggtga 8041 gtgtgaaatt gtgggtttgt gggggtgggt gggtgtgagt gtgtgggttt gtgggtgggt 8101 gtgggtgtga gtgggtgggt gaggggggca tggggatggg tgtgaacatg tagttgttct 8161 ttcaggcata ggacccatag ctctagagct ttcatcagat tctcaaaggg gaccttgact 8221 cggaaaaggt taagacccat tttagagatg agaaattaaa gcctggagct gaggagcgac 8281 tggcccaaag tccctctctg ctctgaggtg cttcgcaggc aaaaacctga accagccccc 8341 taggcagcca ggcctcccaa tggacaccac tcacctcact ccttccagcc atgtacggga 8401 aacagagata gtctccccac cccacccccg tgatcacctc tgtccctacc gatgccacac 8461 acccttctgc cccaggatgt ggctgtctgc atggacctgg atacccggac cacctcgtcc 8521 ctgtggaaag acaaggcagc agtggaaatc aacgtggccg tgctgcacag ttaccaggtg 8581 cagaggccca gactggccag gaaggcaaag ggtttgcata cgggggcagc aggggcgggg 8641 gatggaggag aggcagccat ttagaaacta gggcaggatt tggacaggca gaagaagttc 8701 cgtagtccca gtgccatggc gcacactggc tgcggttcgg ggacagggca ggtactattc 8761 caggcgctgt catctggtgg cttactgtgt gccagggacc ttgctgttta ctgcatgccc 8821 agtcatgctg attctcaggg catattgggt attgcagttt gtgggacccg ctggatcctg 8881 gaaacaaata ccaggatcaa gggcacacca ggagtcgtag tttgaggaag ccggggcctg 8941 ctgagaattt ctgtgggcta tttggtttgg ggaccaggca tgcagatgct ggagattaga 9001 gctgcttgtt gcatgttgaa cctgcagcat gaccatgcat gatgtggttt ggggtgaggg 9061 tgacattgtg gtttgagggg acacagggtg tgttagatat ggggtaatcg agggcacatg 9121 tggtttgggg tgaccggagt ggtggaggaa gaatgggcga ggtctgtggg tctggtttga 9181 gcctctcccc ctctctctcc cttccagcta gccaaagtca ccatcgtgga ccaccacgcc 9241 gccacggcct ctttcatgaa gcacctggag aatgagcaga aggccagggg gggctgccct 9301 gcagactggg cctggatcgt gccccccatc tcgggcagcc tcactcctgt tttccatcag 9361 gagatggtca actatttcct gtccccggcc ttccgctacc aggtgcccac cctaatggct 9421 ctgccagcct gggcccagct ctaattctaa gcagcccctg gggacctcta acctttcctt 9481 ttctttacct cccctcccaa ccccatcatc tctctgcagc cagacccctg gaaggggagt 9541 gccgccaagg gcaccggcat caccaggaag aagaccttta aagaagtggc caagtgggtc 9601 ccctgggagc cccgctctcc cacacacacc ctgggggccc cactctcccc cacacaccct 9661 gggggaccct gccccagcag tgttctggac ctaccactca gtatcccaaa accctgttgt 9721 gagggggttg gacccttgcc tggggaggcc ctgcctctgt gcacccggga caccctcaca 9781 ccttcctctc ccgcagcgcc gtgaagatct ccgcctcgct catgggcacg gtgatggcga 9841 agcgagtgaa ggcgacaatc ctgtatggct ccgagaccgg ccgggcccag agctacgcac 9901 agcagctggg gagactcttc cggaaggctt ttgatccccg ggtagggctg agcccagggg 9961 agcagggagc tagaaagagg gggctctatc agcatcttca ggggtgccct ggaggacagg 10021 aagtgttaca agtcaggact catgaggaac ccggaaccac aggtgttcag agatcaagtt 10081 ggggcctgaa tcttgcactg ccagggaggc cagagtgagg agggcagggc ctccgggggc 10141 cacagcaccc aggacatctg tcttcccacc cacaggtcct gtgtatggat gagtatgacg 10201 tggtgtccct cgaacacgag acgctggtgc tggtggtaac cagcacattt gggaatgggg 10261 atcccccgga gaatggagag gtgagaactt ccaggaaagg ggctgctggg aatgaggaga 10321 gactcagaat tggagtgact gggcaggaac ctctgcccaa cacacacaca cacacacaca 10381 cacacacaca cacacacaca cacacacaca cacacacaca cacacacaca cgccaggatg 10441 gaaagggaga tgctaagaga cccctggagc ctgaaacccc acacaacgta cgctcccagc 10501 ccacccatgt ggctgcctcc ctgcaagcac atttgcttaa ctgcgcgtcc ccaagtcatt 10561 tccattatca gtgcaagttt ttaatacaag gaaggcacat cctggctgac caagaggtta 10621 gactgtgctc gggcactgac aagaaaaaca gggatacgtc actgagggcg gcttctagga 10681 tgcgggtaat gtttcttaat gggatactgg ttacacaggt gtgttcagtt tgtaaaaatc 10741 cacagagctg tacatttaca acatgtacaa cactattcca gcattttatt ttatttgttt 10801 tatttatttt gataacctat ttacgttgcc caggctggcc ttgaactcct agcctcaaga 10861 gatcctcctg ccgcaggctc ctttttcaaa agaagaaatt gagcgctgtt tagatgccaa 10921 catagattaa ataacttcac tttttaaaaa gaaacacaaa gctagagtac catcattgaa 10981 ttccttctct tgcaagctta ggtatctctg aggtgcccca ggctaggctc atttctgagt 11041 cttacctgct ccagcttcta ggtgttaaag gcCttattag cactaaatac ttcctcagta 11101 ctcttttttc ttttttcctt tgagacaggg tctcactttg tggcccaggc tggagtgcag WO 00/09525 PCT/US99/17712 EPI-109 11161 taatacaatc acagctcact gcagcctcaa cctcctagac tcaaacaatc ctcccacttc 11221 aacctcccaa gtagttggga ctacaggcgc atgccatgat gcctaaczaa tttttgtatt 11281 ttttatagag atggggtttc gccatgttgc ccaggctggt ctctaactcc tgggttcaag 11341 caatccacct gcctcggcct cccaaagtgc tgcgattata gacgtgagcc actgcacctg 11401 gcccgcagta tcttaagcaa gttggaatct cgtgaaaccc tttttactgc cttagtgtcc 11461 gtttcagccc tcattcttac ctaccttttc aagaaaaata gcaccagcaa ttgacttttt 11521 tttagcataa aggtgtatag aacccatata acctacagcc ttcacaaagc atagcacatt 11581 ttcaccaccc tggaaagttc cctcatcagt tcctcacgtg aatccctzcc cagtctgtct 11641 ccctgccaga agtgtctgtc accacagaat agtttcgcct gctctagaac ggcacctaga 11701 tggaagcacg cagtgttgcg gcgtctcctg ctgaggctgt ttttgaggcg cactcgtgtt 11761 gctgcgtgac tcagtatttc actcattctg ctgctgagtg ccgttcattg tgtgaatatc 11821 cccagtttgt ttacccattc tcttgttggt gacacttggg ctgtttccag gtcggggcta 11881 ttatgaataa acctgttatg aacattctgt acccggcttt tgtgggctta tgtttttatt 11941 tctcttgggt aaaacctagg agtagaattg gtaggtcata gggtagatgc atgtttaatc 12001 tttcactttt ttaaaaaata aaactgccag gccaggcgcg gctgctcacg cctgtgatcc 12061 cagcactttg ggaggcccag gtgggtggat cacttgaggt cagaagctca agaccagcct 12121 ggccaacatg gcaaaaccct gtctctacta aaaatacaaa aattagctgg gcatggtggc 12181 gcacgcctat agtcctagct actcaggagg ctaggcggga gaattgcttg aacctgggag 12241 gtggaggttg cagtgagccg agatcacgcc actgcactcc agcctgggtg acagagcaag 12301 aattctactt aaaataaaat acaaataaat aaaataaaac tgtcaaacag caaagcaaat 12361 taaactgccc tttaacatct gtgcagttca atgtatgtta attttatccc aaatttttaa 12421 caaatctagg aatacagctc acagaaaatg gggtatattc actaaaaata aggaatattt 12481 atagcaaatt tgtttgtaat accccacact ggaaacaatt caaatgacca tcgacaaata 12541 ctgataaatt gtggtatatt caagtgccat atcgcactaa gtgtgaacaa aacacaacca 12601 cacacaacag tgcaggtgaa tctgaaaaaa tgtgaagaga agaaaaagcc agaccaaaga 12661 atacatactg tactacaggg ttcactttat ataaagttca gaaacaggca gaactaatcc 12721 acggagttag aaattaggag aggagttagt cactgggatg ggggtggcag tgacaggaag 12781 aaggcacgaa gttggcttct aggatgcggg taatgtttgt ttgtttgttt gtttgtttgt 12841 ttttgttttt gagctggagt ctcactctgt tgcccaggct ggagtgcaat ggcgtgatct 12901 cggctcactg caacctccgc ctccccggtt caagcgattc tcctgcctca gcctcccgag 12961 tagctgggat tacaggtgcc cgccaccatg gccagctaat ttttgtgttt ttagtagaga 13021 cgcgtttcac catgttggcc aggctggtct tgaatccctg acctcagcct cccaaagtgc 13081 tgggattaca ggcgtgagcc accacgccca gccacgggta atgtttctcg atgggatgct 13141 ggttgcacag gtgtgttcag tttgtgaaaa cttacagagt tgtacattta caacatgtgt 13201 gcacctctgg acttgtgttg cacgttgaca aaacattcaa aaatgaaatt caaatcgttc 13261 ttgctaactc tggcgcactt gggaaccagc acccagaggc atctgcagtt gagcaccaga 13321 tgcagttcct tccagcttcc ttccccctgg gaggtccgct tgatgccact tcttcatggc 13381 agcacaaaca aggccatggt cttctgagga gggcaacctg cacaatgtct gctagtgacc 13441 aggacactgc tgaaggaact gagagtttgt ccacccatga aatccactaa aacaggaaag 13501 attttgctct agccgttgtt agccaggagt gaggaaagag ctgtgccctc ccctgcagct 13561 gcgaggacga tctgcctgcc ccaacaagtg gggattcagc aactccactt ctaaggatta 13621 cccagctgaa gcatttaaaa gtgggagcaa ggcacacgta caagggcgtt tgagagagca 13681 cctgttccca gaccaccgag ctgcccttca gtctcagtga agtacaatgt agccactaaa 13741 aagactgagg tcatgttttg gaaagtccag gccggaggat cgcttgagcc caggagttca 13801 aggccagact gaacaacaca gcgagactcc atctcttcag aaaatttaaa aattaaccaa 13861 gagtggtggc acgcacctat agatctagct actaggaagg cagaaaaatc ccttaagccc 13921 aggagtttga ggttacagtg aatgatgatg gagccactgc accccaacct gggcgacaga 13981 gcaagaccca tatctaaaaa caatactact acttacgtca atattgttgt attgacctgg 14041 agggatgtct gcaataaatt attgattaaa accaaggaag tacagtatgg taccactttt 14101 acttaaaaaa aaactataaa tatgcacgtg cacgtaagtt caaggaaaaa gggctggaag 14161 gttaacacct gtgaatggcg catatgcccg gaggaagatg gggtggtctt tgtcttatca 14221 ctttacacat ttctgtaatg tcatttttca aaaacatcag atcgcttttg aaattttcaa 14281 aacaaataaa aattaagtga caaatcaata ataatgagga tcagctggta cagttttaaa 14341 cttctatgta gtttgaaatg aaacaaaact aaccctgatg caaacactcc cctcgccaga 14401 gctttgcagc tgccctgatg gagatgtccg gcccctacaa cagctcccct cggccggaac 14461 agcacaagtg agttgggtga gagtttgggg gagctggggg agctgatgca tttggagaca 14521 caaacagaaa gggggtctga aaagctctcc ctctgtgcct caagtcgttt tcccaccaaa 14581 agccagggct ccaggatgcc ctccattcca ggctgcaatg gcagtccaga cctgcctgct 14641 tctgagagcc gggacagtcc tgaggtcttc agagatgggg gtgtggtgtg tcagggcccc 14701 aggctcggaa ccccagggat gctggccctc agcccctccc aagggcaggg cctttcctgt 14761 ccagaggcag agaccctgaa gccgtccctg gggctgggtc tgggcctagc ctgtatcccc 14821 agggccctgt gacaaccttg tctttgtcct ctcttgccag gagttataag atccgcttca 14881 acagcatctc ctgctcagac ccactggtgt cctcttggcg gcggaagagg aaggagtcca 14941 gtaacacaga cagtgcaggg gccctgggca ccctcaggtc agggcctcac caagaggggt 15001 gcaacgggtg ggcaagctgc ctgggcaaac gtggcctgca aagggagctc cactgacgac 15061 ccctgcaccc caggttctgt gtgttcgggc tcggctcccg ggcatacccc cacttctgcg 15121 cctttgctcg tgcggtggac acacggctgg aggaactggg cggggagcgg ctgctgcagc 15181 tgggccaggg cgacgagctg tgcggccagg aggaggcctt ccgaggctgg gcccaggctg WO 00/09525 PCT/US99/17712 EPI-109 1180 15241 ccttccaagt gaacccagcc cagcccctgc tctgactcct gccccctggg atgcctcctc 15301 ctgcctcact ctgccctgat tctgtttagt tctttggtcc cttcctgttc cttccaaaat 15361 ccaccctcat ctctccatgg catagccagc tcttctgggt caggggcaga ggatgacatg 15421 gccctgccga ccacaggggt gcctagccca ggcagaagtg cagccgaaag agagcaggca 15481 gggccctggc aggagggagc ttcagccagg cacaggctgg gcctcacaag tgggcgcaca 15541 aagggagggg gtgcagggca gggcagggga ccccacccag gatgggcagg atggagggag 15601 aaggaaggga cagagagaag gtcagacaga ggcaagggct gaagctgagg ccagcacaga 15661 agccacagga agccagaggc cagacagcct ggggcggtgc ctgcaccaga actggtccgg 15721 gccaggcaag caaacacagg gagaggtgga tccctggggg ctgtggcttt ttaagcctgg 15781 gcttcctcag gggcagtgct gcctgtctgg ggatcatgtc tgcagttgac aagggctcgg 15841 tctccccagt gccacactgt tcagggcagt gctgctgtcc cggggcccag gctggagctc 15901 agcagatttg ccttgattgg aggaggaggg catcctagga ggagagggag tgggggctac 15961 ctcagggacg gggaggtcag gctgcagaaa cacataggcc ctgattggga agaagggaca 16021 cggtaaaata agctctaaaa gaatttaaaa caaaaagagc cattgcagcg ggatgagacc 16081 acatcatcag gttttgggaa taggacttta gaggcgtagg atccattaca gcatcaccga 16141 accagaagca ggaaggctga gctaagcaga gcagcagcag tggagatagg aaggaaggga 16201 gggaggggcc gaggaaggaa ggaagagata taagacttca cacgcaccac aaaagaaaga 16261 ttaacgggac ttggtgatat gaggctcagc caatcacggg tgagccctgc atttcaagcc 16321 tgggactggc ccagcagttt tccagctgtg tgcctgacca ggagtagacg ggatccacac 16381 cctcccaggg atctgccccg tggggtcccc tctgccgccc gaattgtgcg tcccttccca 16441 ggagcactta ctatctgcac gcactttgtg gaaagctaag ggctttacat aaagtatctc 16501 atttaatctt caccagaaca caatgaggtg taaagatggg gaaactgagg catgtcactg 16561 taagtacggg attcggaatt tgaatgcagg tctgaacaca cagacgcctt cacagagcta 16621 ccgtgtgcca agcactatgc ttctcggatc acgggattaa cacgcaccag ataaggaacg 16681 atgcaccaat caggacgtgc agagaaagag ccagccgggt ccctgggccc agcggccaat 16741 ccatgaaatg ggctggcgga aaaggtgctg tccttggcgc cggcctcagc cactggggct 16801 gccaaccccc caggagcaag acgcagtgaa gccgcccagg cgcctcacta gggcgacccc 16861 tggtggcggg aggtcctcag ccctcaccgg cctgtcccgc aggccgcctg tgagaccttc 16921 tgtgtgggag aggatgccaa ggccgccgcc cgagacatct tcagccccaa acggagctgg 16981 aagcgccaga ggtaccggct gagcgcccag gccgagggcc tgcagttgct gccaggtggg 17041 ccctgcctca ccctaacccg gctggttctc tgaggccccc acaccccggg actaaagcac 17101 tctggggcca ggccctgctc cctagctcag gctgcctcat ttgcccctcc ccgcccccag 17161 gtctgatcca cgtgcacagg cggaagatgt tccaggctac aatccgctca gtggaaaacc 17221 tgcaaagcag caagtccacg tgaggacgac ggctttaccg ccccccaacc cctgtcctga 17281 acaccctgac cctggaccct cctcctccca cattctcccg cccccacccc tctctgactc 17341 cccataagtg cccctctccc cacccccagg agggccacca tcctggtgcg cctggacacc 17401 ggaggccagg aggggctgca gtaccagccg ggggaccaca taggtgtctg cccgcccaac 17461 cggcccggcc ttgtggaggc gctgctgagc cgcgtggagg acccgccggc gcccactgag 17521 cccgtggcag tagagcagct ggagaagggc agccctggtg aggggcagcc tgggaagcaa 17581 cagggcacac cagccccatg cccagcccca cccccggccc caggcctcca ggagctcagg 17641 acccgaccca gggggtggcc acctcctcca cagctcagca ggcaggctca gagctggctg 17701 tgctgcccac tgccgggctg gccttgttgc tggaccatcc ccacaccctc aaatgcaccc 17761 ccaccaaaag gctgtcccct ccctctgggc tcctctccaa ggctccccta gcaatctagc 17821 ttgctctgga gctggcactg gggctatttg ctgccacatc aatgcctggg ctttatttaa 17881 aataaggggg tggagtcaga ggcagaggag cccagaccaa cccagtccgg ccaggggccc 17941 ccgaacaata cactgaggct acctagacag gccgaccccg ctgctcaagg gcaggctctc 18001 taacagtcac caaaacacaa acatcagccc aggtactgca gtcctgctgg gccctgtcct 18061 cagagctccc tgtgcactat ccccaggtgg ccctcccccc ggctgggtgc gggacccccg 18121 gctgcccccg tgcacgctgc gccaggctct caccttcttc ctggacatca cctccccacc 18181 cagccctcag ctcttgcggc tgctcagcac cttggcagaa gagcccaggg aacagcagga 18241 gctggaggcc ctcagccagg ttgggggcca ccccaatgag gcacaggggc tagagagacg 18301 ggatgagctg gggggacccc agtggcagga aacccccatg caaagtcccc cctggacttt 18361 cttctcctgg ctgacatgca ctggtgcttt aagacccagc tcctcaggga ggaattcatg 18421 gctggattct ccaggtctta gagaaaactc tattggcctg aactgagcag ggagaaaccc 18481 taaagaggct cagtggggga ggggtcaaga agggaggtta ctaggaaggg ctatggggcc 18541 tccaacccac tgcatcctgc cccgccagga tccccgacgc tacgaggagt ggaagtggtt 18601 ccgctgcccc acgctgctgg aggtgctgga gcagttcccg tcggtggcgc tgcctgcccc 18661 actgctcctc acccagctgc ctctgctcca gccccggtac tactcagtca gctcggcacc 18721 cagcacccac ccaggagaga tccacctcac tgtagctgtg ctggcataca ggactcaggg 18781 tgaggcaaca agcaggagca ggcctggcca cagcagggtt gggaccggcc cctctctggc 18841 ccctcaccgg cctctccttc ccacccccag atgggctggg ccccctgcac tatggagtct 18901 gctccacgtg gctaagccag ctcaagcccg gagaccctgt gccctgcttc atccgggggt 18961 aagtgagatg gaggacttgg tggggagctg cccagggtca gggtggcagc tttggtgagg 19021 agtgtcactg gtgaggggtg tcactggaaa caggaaggag ctctgtaaca tgtcaagggt 19081 gtggtgtcat taggtcactt cagaactctg gctaagcttt ggctctctca ttcatttaga 19141 ctcagagttc tgccctgaaa ctatagctcc cagagccaga gctggtatca aaccggctgg 19201 ccctgtggct ttctgaaagc ttctgtgttc ctctctatgt ccctgggctg tctgatgttg 19261 ggcagcatgg cacctgggaa ctacagtcac taaatcctca ctcaatccag ggagaactac WO 00/09525 PCT/US99/17712 EPI-109 1181 19321 taattagggt taaaacc--c czz-ggccz- ggtgccca aggactcaaa gaaggtgaaa 19381 gttttggtct tttttccagagatgaa qtcttaczct gtcgcccagg ctggagtgca 19441 gtggtacgat ctcggcctaz tgcaacctcc acctcccagg ttcaagagat tctcctatgg 19501 cgtgaacctg ggaggtggag cttgcagtga gccaagactg tcccactgca ctccagcctg 19561 ggcgacagag ccagacc: tctcaaaaaa aaaaaaaaaa tattctcctg tctcagcctc 19621 ctgagtagct gggattacag gcacccacca ccacqcccag ctaatttttg tatttttagt 19681 agagacggtg tatcactatg ttggccaggc tggtctcgag ctcctgacct cacaacctc 19741 ccacctccgc ctcccaaagc cttgggata caggtgtgag ccaccgcgcc cggaccgagg 19801 gtgaaggatt ttaagagacc ctcccttcac gctgtgtcca gaagtcttgc ccgctctcgc 19861 agccaggaac caaaagtcc ggtaggact agaacagttc ccaggctgcc atcagctggg 19921 cctggtgat caaatccacc caggtggcta aactacaaat aaaccgtacc catctactga 19981 acataaacta aataccacza ttaagqatac ttaaaataaa cacacttagt gaacccatta 20041 tgaactgaaa gtgtctttca cccttcccac gttttctaaa tcccctgagt catctaagta 20101 ttcttcaatc caaaatgaac tatatttccc tggtgcaag ctccagaaac cacagatcca 20161 aggagtttca gcaagtagag ttgttttttg ttttttgttt tttttttaat ttttttttga 20221 gatgggaaga acttgggtcc tccttgctcc acccaccctg catggtgaga atggtggagc 20281 aggaaaggca aaggggacc gatggagtgt ctctcctgcc agggctccct ccttccggct 20341 gccacccgat cccagcttac cctgcatcct ggtgggtcca ggcactggca ttgccccctt 20401 ccggggattc tggcaggagc ggctgcatga cattgagagc aaaggtgagg ctggtgacta 20461 aaggactgcc tgaagggagt cacacaatct agggacagag gggtggggct ggaaggcagg 20521 aaataggaaa gagagggcag gaaacaaagt ccacaaagct gaaaagacgc tcatgagacc 20581 aaggggaggg caggtaccaa aggcaagggc tgggccccga gcttctggct tcctggtgcc 20641 tggtacatag taggtgttga ctggattgag gacaaaggaa aatagaattt tcaaagggat 20701 tagggctaag actcaaagaa gaactgccca aggtggattc ttgactgtgc cagagctgac 20761 cgaggtctgt ccaagaccta aggatgctac aaggtgttca tattgagcat ggggtgccca 20821 gggtggcctg tcaatcaaaa gaagagggct qtgactggga ggagagttat aagtatggga 20881 gaagatgaag tgggagcggg gaaggggact gcgagtcac acaatgcaaa gggcatggaa 20941 ttctgagtcc gaagccgcgc attctagcgc actccaccag gggccaccac ctcacccgcg 21001 cttcccttcc ctctgtaaa cagggctgtg cagggtctct gtgaaagcat tctacactct 21061 cttagagatg aaacagccaa agtaatggtg gtttcagccc aaaacgctgg gctgccaggc 21121 tgggcgacgg tggcctgtgg ggaggcccca ctagcactgt gccccggaga agagccttcc 21181 caagcgcggg gttgcttgca gggctgcagc ccactcccat gactttggtg ttcggctgcc 21241 gatgctccca acttgaccat ctctaccgcg acgaggtgca gaacgcccag cagcgcgggg 21301 tgtttggccg agtcctcacc gccttctccc gggaacctga caaccccaag gtgtgagacc 21361 ctgagggcgc aatggtaacc tgaagatagg gagagagggg aggactcgcg ctctccagcg 21421 gggcacacca accacggccc tcccgtggcc tcccacgacc actcagccac ccctgcacac 21481 tctggcccac ccttgtgccc cggcccctct aggccccgcc tcctcccgcc cctgccccgc 21541 ccctttggct ctgccctgtt gacaacgccc cagggcacgc aggccccacc aggcccgctc 21601 cggagaattt caaggtccag ggccagccag cagccccggg ctgcccccgc gcccaccccc 21661 accagggccc gccctaaccc cgccgccccg cagacctacg tgcaggacat cctgaggacg 21721 gagctggctg cggaggtgca ccgcgtgctg tgcctcgagc ggggccacat gtttgtctgc 21781 ggcgatgtta ccatggcaac caacgtcctg cagaccgtgc agcgcatcct ggcgacggag 21841 ggcgacatgg agcggacga ggccggcgac gtcatcggcg tgctgcgg gcggaggggc 21901 gggccgggcc cgagcgtgcg gggttcctgc caaggtctcc gagtcgggtt ctgatccact 21961 gtgctctttt ccgacaggac cagcaacgct accacgaaga cattttcggg ctcacgctgc 22021 gcacccagga ggtgacaagc cgcatacgca cccagagctt ttccttgcag gagcgtcagt 22081 tgcggggcgc agtgccctgg gcgttcgacc ctcccggctc agacaccaac agcccctgag 22141 agccgcctgg catcccttc cagttccggg agagcggctg cccgactcag gtccgcccga 22201 ccaggatcag ccccgctcct cccctcttga ggtggtgcct tctcacatct gtccagaggc 22261 tgcaaggatt cagcattatt cctccaggaa ggagcaaaac gcctcttttc cctctctagg 22321 cctgttgcct cgggcctggg tccgccttaa tctggaaggc ccctcccagc agcggtaccc 22381 cagggcctac tgccacccgc ttcctgtttc ttagtcgaat gttagattcc tcttgcctct 22441 ctcaggagta tcttacctgg aaagtctaat ctctaaatca agtatttatt attgaagatt 22501 taccataagg gactgtgcca gatgttagga gaactactaa agtgcctacc ccagctcatg 22561 tggattacag tttttttttt ttgttttttt ttttttgaaa cggagtctcc ctctgccgcc 22621 cgggctggag tgcagtggcg tgatctcagc tcactgcaac ctccacccca caagttcaag 22681 tgattctcct gcctcagcct cccaagtagt tgggattaca ggtgcctgcc accgcgcccg 22741 gctaggtttt gtatttttag taaagacggg gtttcaccat cttggccagg ctggtcttga 22801 actcctgacc tcgtgatcca accgcctcag cctcccaaag tgctgggatt acaggtgtga 22861 gctactgcac ccggcgtgga ttacaattat aaaatgacaa gatttctgtc ttaacctgtg 22921 cagttgtggg tatgtggtgg ggaaaggggt cattctttta acagagtcct acacgccact 22981 tgaccctgca ctctgaaaac atggtttcca gccagtctgg gctgctcccc cgtgcagttc 23041 tcaggctcgt aatcgagaag gcaggtgcag cactcagctg ccaggagtgg ggcctgccag 23101 aaacaagagt cacagagatg tgcaacagcc atgagcaagc tt (2) INFORMATION FOR SEQ ID NO: 33: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 3690 base pairs (B) TYPE: nucleic acid WO 00/09525 PCT/US99/17712 EPI-109 1182 (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:33: cagagtggac gcacagtaac atgggcaact tgaagagcgt ggcccaggag cczaggccac 61 cctgcggcct ggggctgggg ctgggccttg ggctgtgcgg caaacagggc ccagccaccc 121 cggcccctga gcccagccgg gccccagcat ccctactccc accagcgcca gaacacagcc 181 ccccgagctc cccgctaacc cagcccccag aggggcccaa gttccctcgt gtgaagaact 241 gggaggtggg gagcatcacc tatgacaccc tcagcgccca ggcgcaacag gatgggccct 301 gcaccccaag acgctgcctg ggctccctgg tatttccacg gaaactacag ggccggccct 361 cccccggccc cccggcccct gagcagctgc tgagtcaggc ccgggacttc atcaaccagt 421 actacagctc cattaagagg agcggctccc aggcccacga acagcggctt caagaggtgg 481 aagccgaggt ggcagccaca ggcacctacc agcttaggga gagcgagcg gtgttcgggg 541 ctaagcaggc ctggcgcaac gctccccgct gcgtgggccg gatccagtgg gggaagctgc 601 aggtgttcga tgcccgggac tgcaggtctg cacaggaaat gttcacctac atctgcaacc 661 acatcaagta tgccaccaac cggggcaacc ttcgctcggc catcacagtg ttcccgcagc 721 gctgccctgg ccgaggagac ttccgaatct ggaacagcca gctggtgcgc tacgcgggct 781 accggcagca ggacggctct gtgcgggggg acccagccaa cgtggagatc accgagctct 841 gcattcagca cggctggacc ccaggaaacg gtcgcttcga cgtgctgccc ctgctgctgc 901 aggccccaga tgagccccca gaactcttcc ttctgccccc cgagctggtc cttgaggtgc 961 ccctggagca ccccacgctg gagtggtttg cagccctggg cctgcgctgg tacgccctcc 1021 cggcagtgtc caacatgctg ctggaaattg ggggcctgga gttccccgca gcccccttca 1081 gtggctggta catgagcact gagatcggca cgaggaacct gtgtgaccct caccgctaca 1141 acatcctgga ggatgtggct gtctgcatgg acctggatac ccggaccacc tcgtccctgt 1201 ggaaagacaa ggcagcagtg gaaatcaacg tggccgtgct gcacagttac cagctagcca 1261 aagtcaccat cgtggaccac cacgccgcca cggcctcttt catgaagcac ctggagaatg 1321 agcagaaggc cagggggggc tgccctgcag actgggcctg gatcgtgccc cccatctcgg 1381 gcagcctcac tcctgttttc catcaggaga tggtcaacta tttcctgtcc ccggccttcc 1441 gctaccagcc agacccctgg aaggggagtg ccgccaaggg caccggcatc accaggaaga 1501 agacctttaa agaagtggcc aacgccgtga agatctccgc ctcgctcatg ggcacggtga 1561 tggcgaagcg agtgaaggcg acaatcctgt atggctccga gaccggccgg gcccagagct 1621 acgcacagca gctggggaga ctcttccgga aggcttttga tccccgggtc ctgtgtatgg 1681 atgagtatga cgtggtgtcc ctcgaacacg agacgctggt gctggtggta accagcacat 1741 ttgggaatgg ggatcccccg gagaatggag agagctttgc agctgccctg atggagatgt 1801 ccggccccta caacagctcc cctcggccgg aacagcacaa gagttataag atccgcttca 1861 acagcatctc ctgctcagac ccactggtgt cctcttggcg gcggaagagg aaggagtcca 1921 gtaacacaga cagtgcaggg gccctgggca ccctcaggtt ctgtgtgttc gggctcggct 1981 cccgggcata cccccacttc tgcgcctttg ctcgtgccgt ggacacacgg ctggaggaac 2041 tgggcgggga gcggctgctg cagctgggcc agggcgacga gctgtgcggc caggaggagg 2101 ccttccgagg ctgggcccag gctgccttcc aggccgcctg tgagaccttc tgtgtgggag 2161 aggatgccaa ggccgccgcc cgagacatct tcagccccaa acggagctgg aagcgccaga 2221 ggtaccggct gagcgcccag gccgagggcc tgcagttgct gccaggtctg atccacgtgc 2281 acaggcggaa gatgttccag gctacaatcc gctcagtgga aaacctgcaa agcagcaagt 2341 ccacgagggc caccatcctg gtgcgcctgg acaccggagg ccaggagggg ctgcagtacc 2401 agccggggga ccacataggt gtctgcccgc ccaaccggcc cggccttgtg gaggcgctgc 2461 tgagccgcgt ggaggacccg ccggcgccca ctgagcccgt ggcagtagag cagctggaga 2521 agggcagccc tggtggccct ccccccggct gggtgcggga cccccggctg cccccgtgca 2581 cgctgcgcca ggctctcacc ttcttcctgg acatcacctc cccacccagc cctcagctct 2641 tgcggctgct cagcaccttg gcagaagagc ccagggaaca gcaggagctg gaggccctca 2701 gccaggatcc ccgacgctac gaggagtgga agtggttccg ctgccccacg ctgctggagg 2761 tgctggagca gttcccgtcg gtggcgctgc ctgccccact gctcctcacc cagctgcctc 2821 tgctccagcc ccggtactac tcagtcagct cggcacccag cacccaccca ggagagatcc 2881 acctcactgt agctgtgctg gcatacagga ctcaggatgg gctgggcccc ctgcactatg 2941 gagtctgctc cacgtggcta agccagctca agcccggaga ccctgtgccc tgcttcatcc 3001 ggggggctcc ctccttccgg ctgccacccg atcccagctt gccctgcatt ctggtgggtc 3061 caggcactgg cattgccccc ttccggggat tctggcagga gcggctgcat gacattgaga 3121 gcaaagggct gcagcccact cccatgactt tggtgttcgg ctgccgatgc tcccaacttg 3181 accatctcta ccgcgacgag gtgcagaacg cccagcagcg cggggtgttt ggccgagtcc 3241 tcaccgcctt ctcccgggaa cctgacaacc ccaagaccta cgtgcaggac atcctgagga 3301 cggagctggc tgcggaggtg caccgcgtgc tgtgcctcga gcggggccac atgtttgtct 3361 gcggcgatgt taccatggca accaacgtcc tgcagaccgt gcagcgcatc ctggcgacgg 3421 agggcgacat ggagctggac gaggccggcg acgtcatcgg cgtgctgcgg gatcagcaac 3481 gctaccacga agacattttc gggctcacgc tgcgcaccca ggaggtgaca agccgcatac 3541 gcacccagag cttttccttg caggagcgtc agttgcgggg cgcagtgccc tgggcgttcg 3601 accctcccgg ctcagacacc aacagcccct gagagccgcc tggctttccc ttccagttcc 3661 gggagagcgg ctgcccgact caggtccgcc (2) INFORMATION FOR SEQ ID NO:34: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 30417 base pairs WO 00/09525 PCT/US99/17712 EPI-109 1183 (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:34: 1 gggcccagag aaagagctgt ccccggggcc ttggggacag ggtgacagcc acccagagat 61 catggagaag gggacgtaag gaagacctca cagaggagtc atcctgcgac tgtgttggtt 121 gggtccttca ggaagcagag tcccaggagt tggaagcata agaggaatac tgcgggcaat 181 gcctgagaaa gataacaggg accgggagca ggagtgagtt gggcagggga aggatcaggc 241 ccacaatgcc aggctcacac ctgcagagga gggaagaaga agaagggcct cacatcagcc 301 cagcggggga tgttacgccc acagacgccc cggggctcag ttactgtcta agtgttagaa 361 ataaattttc ggtgccacaa aagaaatagc actcagatta aatgttccca gcaaggcaat 421 tttacttcta tagaagggtg catctcacag atggagcaat ggcaagagca cacctgaaca 481 agggaaggga aggggttttt atccctaagg caggtagccc ctacagctgt gttgttcccc 541 tattggctag ggttggacca caccgtctga gctaattgtt actggctatt ttaaagagag 601 caggggtaag agccggattg gcagggtaag tagtttggca ggaaggacgg tcacagaaca 661 ggtgactcag gatgactcag gtcagagcag gtgaccagtg gtgactcagt tcggagcagg 721 tgatagaagc taggaggggg ttgtttactg aaactagggg caaggagacg aagagaacat 781 gaaagttaaa ctttaagatg aagaacaaag ctgaacatac tgatgcattg gatctttgga 841 gaggatctca gaactcattg tacttaattt acaggctaaa accttagaag aggaatttat 901 tatatcctac acaagactcc agggaagcac atggccttgg actgaaggct ggcatctgga 961 agctgtcagc caccagcacc ttctgcagca ggtacctgct ctctaagagg gaggcctggg 1021 tggtgcacct ccagagctgc ccaggctggg cctcaaggaa gaaaaagatt ttcatttgtc 1081 agaggcggaa gggagaggtg gagggaacag cacagcagcg gcccaggggc agggaagcac 1141 aggaccatta gggagacacg agaaagccca tttgtctaga acagaggatt caagcagtgc 1201 accaaggaaa atgagggcca ggccaatgtg ctggagtggc tttgttcttg gctgagggtt 1261 ttgggtagtg ccaaagcgta aggtaagccc tgctttccag aagaatctag cagagtgtgg 1321 agcccagatg ggactggaag gcctgggagg ggtcaggtgg ccacagggac gggccacagc 1381 cagtggtgca ggcaagaaga caatggccat ccatggtggc tcacacctgg aatcccagcc 1441 cattgggagg tcgaggcagg tggatcacct gaggtcagga gttcgagacc agcctggtca 1501 acatggtgaa accctgtctc taataaaatt ataaaaatta gccgggcgtg gtggtgggta 1561 cctgtaatct cagctactca ggaggctggg tcaggagaat cgcttgaacc caggaggcgg 1621 aggttacagt gagctgagat agcaccattg cattccagcc tggacaacaa aagcgagact 1681 ctgtctcaaa aaaaaaaaaa aattagccag gcgtggtggt gggtgcctgt cgtcctcggg 1741 aggctgaggc atgagaatca ctccgggagg cagaggttgc aatgaaccaa gatcacacca 1801 ctgcactcca gcctgggtga cagagcaaga ctctgtctaa aaaaaaaaaa aagacagaag 1861 gatgtcagca tctgatgctg cctgtcacct tgaccctgag gatgccagtc acagctccat 1921 taactgggac ctaggaaaat gagtcatcct tggtcatgca catttcaaat ggtggcttaa 1981 tatggaagcc acacttggga tctgttgtct cctccagcat ggtagaagat gcctgaaaag 2041 taggggctgg atcccatccc ctgcctcact gggaaggcga ggtggtgggg tggggtgggg 2101 cctcaggctt ggggtcatgg gacaaagccc aggctgaatg ccgcccttcc atctccctcc 2161 tcctgagaca ggggcagcag ggcacactag tgtccaggag cagcttatga ggccccttca 2221 ccctccgatc ctccaaaact ggcagacccc accttcttcg gtgtgacccc agagctctga 2281 gcacagcccg ttccttccgc ctgccggccc cccacccagg cccaccccaa ccttatcctc 2341 cactgctttt cagaggagtc tggccaacac aaatcctctt gtttgtttgt ctgtctgtct 2401 gctgctccta gtctctgcct ctcccagtct ctcagcttcc gtttctttct taaactttct 2461 ctcagtctct gaggtctcga aatcacgagg cttcgacccc tgtggaccag atgcccagct 2521 agtggccttt ctccagcccc tcagatggca cagaactaca aaccccagca tgcactctgg 2581 cctgaagtgc ctggagagtg ctggtgtacc ccacctgcat tctgggaact gtagtttccc 2641 tagtccccca tgctcccacc agggcatcaa gctcttccct ggccggctga ccctgcctca 2701 gccctagtct ctctgctgac ctgcggcccc gggaagcgtg cgtcactgaa tgacagggtg 2761 ggggtggagg cactggaagg cagcttcctg ctcttttgtg tcccccactt gagtcatggg 2821 ggtgtggggg ttccaggaaa ttggggctgg gaggggaagg gataccctaa tgtcagactc 2881 aaggacaaaa agtcactaca tccttgctgg gcctctatcc ccaagaaccc aaaaggactc 2941 aagggtgggg atccaggagt tcttgtatgt atggggggag gtgaaggaga gaacctgcat 3001 gaccctagag gtccctgtgg tcactgagag tgtgggctgc catcccctgc tacagaaacg 3061 gtgctcacct tctgcccaac cctccaggga aaggcacaca ggggtgaggc cgaaccttcc 3121 gtctggtgcc acatcacaga aggaccttta tgaccccctg gtggctctac cctgccactc 3181 cccaatgccc cagcccccat gctgcagccc cagggctctg ctggacacct gggctcccac 3241 ttatcagcct cagtcctcac agcggaaccc aggcgtccgg ccccccaccc ttcaggccag 3301 cgggcgtgga gctgaggctt tagagcctcc cagccgggct tgttcctgtc ccattgtgta 3361 tgggataggg gcggggcgag ggccagcact ggagagcccc ctcccactgc cccctcctct 3421 cggtcccctc cctcttccta aggaaaaggc cagggctctg ctggagcagg cagcagagtg 3481 gacgcacagt aacatgggca acttgaagag cgtggcccag gagcctgggc caccctgcgg 3541 cctggggctg gggctgggcc ttgggctgtg cggcaagcag ggccc 1 ggatcccatg ccctgcctca ctgggaaggc gaggtggtgg ggtggggtgg ggcctcaggc 61 ttggggtcat gggacaaagc ccaggctgaa tgccgccctt ccatctccct cctcctgaga 121 caggggcagc agggcacact agtgtgcagg agcagcttat gaggcccctt caccctccat 181 cctccaaaac tggcagaccc caccttcttg gtgtgacccc agagctctga gcacagcccg 241 ttccttccgc ctgccggccc cccacccagg cccaccccaa ccttatcctc cactgctttt WO 00/09525 PCT/US99/17712 EPI-109 1184 301 cagaggagtc tggccaacac aaatcctctt gtttgtttgt ctgtctgtct gctgctccta 361 atctctgcct ctcccagrct ctgagcttcc gtttctttct taaactttct ctcagtctct 421 gaggtctcga aatcacgagg cttcgacccc tgtggaccag atgcccagct agtggccttt 481 ctccagcccc tcagatgaca cagaactaca aaccccagca tgcactctgg cctgaagtgc 541 ctggagagtg ctggtgtacc ccacctgcat tctgggaact gtagtttccc tagtccccca 601 tgctcccacc agggcatcaa gctcttccct ggctggctga ccctgcctca gccctagtct 661 ctctgctgac tgcggccccg ggaagcgtgc gtcactgaat gacagggtgg gggtggaggc 721 actggaaggc agcttcctgc tcttttgtgt cccccacttg agtcatgggg gtgtgggggt 781 tccaggaaat tggggctggg aggggaaggg ataccctaat gtcagactca aggacaaaaa 841 gtcactacat ccttgctggg cctctatccc caagaaccca aaaggactca agggtgggga 901 tccaggagtt cttgtatgta tggggggagg tgaaggagag aacctgcatg accctagagg 961 tccctgtggt cactgagagt gtgggctgcc atcccctgct acagaaacgg tgctcacctt 1021 ctgcccaacc ctccagggaa aggcacacag gggtgagccg aaggcccttc cgtctggtgc 1081 cacatcacag aaggaccttt atgaccccct ggtggctcta ccctgccact ccccaatgcc 1141 ccagccccca tgctgcagcc ccagggctct gctggacacc tgggctccca cttatcagcc 1201 tcagtcctca cagcggaacc caggcgtccg gccccccacc cttcaggcca gcgggcgtgg 1261 agctgaggct ttagagcctc ccagccgggc ttgttcctgt cccattgtgt atgggatagg 1321 ggcggggcga gggccagcac tggagagccc cctcccactg ccccctcctc tcggtcccct 1381 ccctcttcct aaggaaaagg ccagggctct gctggagcag gcagcagagt ggacgcacag 1441 taacatgggc aacttgaaga gcgtggccca ggagcctggg ccaccctgcg gcctggggct 1501 ggggctgggc cttgggctgt gcggcaagca gggcccagcc accccggccc ctgagcccag 1561 ccgggcccca gcatccctac tcccaccagc gccagaacac aggtaagggc caggcagcta 1621 ggagcaggtg ggcaacaagg gtggtgtcaa ggcctgaagc ctggggctgg gaaggtctgg 1681 aacttgtagc tgagtcggga gggccaggtc acaaatgcaa aagggctatt aatgtgcata 1741 gaacaggaca gtctgggagg ctcagaaagg agaccaggat cagagtcggc aggtgaagct 1801 gggagtaagg gtgccagcta tagaatctgg ccagggtttg aatgctgctc tgccgccagg 1861 agctgtttga ctttgagcaa gttacttaat ctctctgaac ctccatttat ataaaacgag 1921 atatggcaat acttactcca tggggaagta agtttctagc tcacagcaag ccttcaacag 1981 cagcgatgat tatttagctg gagaagaaag gagctgacag cagtggttac aggagtgaga 2041 aagtggggtc tcccagaaga gggagagagt tgggcaggaa actcgggccc ttggggtaag 2101 caggctgaga agacagagcc accaggcttt tttcccctgc tccagccccc tctcctcgtg 2161 gctgtcaccc gaaaactgga ccatgcagtt cccacaagag tcctcccggg ggtagaggtc 2221 ccaggaggga ggaaagaccc ggaggcctgg tggggtgcca ggccgggggc aggctggggc 2281 tgcaggcagc tatgcaggga aggctgaggg ccggggccct gctgctcagg cgcacccttg 2341 gcctgagtcc ctcccttcct ccctgccgct ggtggctctg ggaggaagtg ataaggcctg 2401 cgaggcttcc cttcacacat ggggctgctg tcaggagggg ttgtgagtgc ggagggaaat 2461 cagagctgag gaatccctgc agggcttccc tccactcaag caccaggctc tgtccccctc 2521 agggtagggc ttatagcagc tttgcggggg gtggacaccc catctccaga agaggtgagg 2581 tgggcgctgc aggtgggatg cgaacttagc ctcgggtcag gggctcagga gctcagcacc 2641 agcagcccct gcagcccagg accctggtct ataaacggag gcacagctcg cctctagctc 2701 ctaaggcatg gggaacgcca gaaggcatgc ggcaggtggg ctgtgagatc gccagtgctg 2761 taacaggggc ctccgggtga catctgggaa ggctgaaagg aaacaaaccc ttcctgatga 2821 ccctatccct ggctcccaac agccccccga gctccccgct aacccagccc ccagaggggc 2881 ccaagttccc tcgtgtgaag aactgggagg tggggagcat cacctatgac accctcagcg 2941 cccaggcgca gcaggtaagg ccggcatgcc ctgtccccat cgtctccagg gaaagggtgg 3001 gtaaggcctg gcctcagatg gggccggaga gggaagctca acccttcttt gaattggtcc 3061 cttgtttcca aaaagaggag aggactggga agaaccagag gagttgaggg acatgcacgg 3121 gacttgggtg accctcagcc tccagcctta cccccaaccc tggctcaaac ttttccccca 3181 tcccacccct gcaccccttt tccccctccc acccctgcac ccttcctccc tctcccccac 3241 cccacccctg ccccccctcc catcccagct ctaaacccct cctccctctc ccccgtccca 3301 cccctaaacc ccacctccct gtccccctct aaacccctcc tccctgtccc cctctaaacc 3361 ccacctccct ctccccatcc cacccctgca cccttcctcc ctctgccccc gtcccacgcc 3421 tgtactcctc ctccctctcc cccgtcacac ccctgcaccc ctcctccctc tccccatccc 3481 atccctgcac ccctcctccc tctgcccccg tcccacccct aaacccctcc tccctctgcc 3541 ccaccccacc cttgcacccc tcctccctct tcccccgtcc cctgcctgca ttcctcctcc 3601 ctctccccat ctcacccctg cacccctctt ccctctccca cccctgcacc cctcctccct 3661 ctccccgtcc caccctgcac tcccgccctc tccagcgtcc cacccctaca cccctcctcc 3721 ctctgcccca ttccacccct gcaccccctc ctccctctgc cccgacccac ccctgcaccc 3781 ctcctccctc tcccccgtcc cacccctgca tccctcctcc ctctgccccg tcccacccct 3841 acacccctcc tccctctccc ccatcccacc cctaaacccc tcctccctct cccctgtccc 3901 atccctgcac ccttcctccc tctccccgtc ccatccctgc acccttcctc cctctccccg 3961 tcccatccct gcacccctcc tccctctgct cccatcccac ccctgcaccc ctcctccctc 4021 tgcccctacc ccacctctgc acccctcctc cttctcccca tcccacccct gcacccctcc 4081 tccctctgcc cctaccccac ccctgcaccc ctcctccttc tccccatccc acctctgcac 4141 ccctcctccc tctcccctct cccacccctg tacccttcct ccttctcccc gtcccacccc 4201 tgcacttctc ctccctctaa cccatcccac ccctgcaccc ttcttccctc tcccccatcc 4261 caccactgca cccctcctcc ctctccccct gttccacccc tgcacccctc ctccctgccc 4321 ccaactccca tcccacccct gcaccctggc ctgtcctgac ctttgcactc cctcgaccca WO 00/09525 PCT/US99/17712 EPI-109 1185 4381 ggatgggccc tgcaccccaa gacgctgcct gggctzzctg gratttccac ggaaactaca 4441 gggccggccc tcccccggcc ccccggcccc tgagcaactg ctgagtcagg cccgggactt 4501 catcaaccag tactacagct ccattaagag gtgacagctt cccggacgcc acagcctccc 4561 ttgtcccact gaggccccag aaaccccgtg acgaccztcc catgaccccc tcccttccca 4621 gatcctaaca ccacgtgggc ccctcccgcc ctcccccagc acttgcacaa agcctggagg 4681 agggcctccc tgtcccacac aacttcctgc ttgtcccctt cccacccctc tcctccccag 4741 gagcggctcc caggcccacg aacagcggct tcaagaggtg gaagccgagg tggcagccac 4801 aggcacctac cagcttaggg agagcgagct ggtgttcggg gctaagcagg cctggcgcaa 4861 cgctccccgc tgcgtgggcc ggatccagtg ggggaaactg caggtgcggc tggccagcga 4921 ctgagagacc cgggcgctac caaaagggga gcggggtggc ggggcagttc ctaaggcttc 4981 ccgggggctg ggaggtccca aactgtgggg gagatccttg ccttttccct tagagactgg 5041 aaaggtaggg ggactgcccc accctcagca cccaggggaa cctcagccca gtagtgaaga 5101 cctggttatc aggccctatg gtagtgcctt ggctggagga ggggaaagaa gtctagacct 5161 gctgcagggg tgaggaagtc tagacctgct gcaggggtga ggaagtctag acctgctgca 5221 ggggtgagga agtctagacc tgctgcgggg gtgaggaagt ctagacctgc tgcgggggtg 5281 aggacagctg agcggagttc cctgggcggt gctgtcagta gcaggagcag cctcctggaa 5341 aagccctggc tgctgcttct cccccaagag agaaggcttc tcccgccagg ccagtccagt 5401 gcagcccctc acccacaccc actgctaccc cagttcccct gcttcggccc gcaccctccc 5461 tcacacccca gcccacagac tcggggctgg ccttagttac tggaacgcct gtgaccacag 5521 cactaagaga agcaagctgc cccatggggg acttggtccc catggccttg gcctccttca 5581 ccatcactgg ccgccaaaga gtttgaaata aagccacgtg cccagtgaat cccaaaggaa 5641 cctcaactaa aataaaaaca atcctatctg acacttgcct gaccctctaa gtcattcaaa 5701 gctttagctc aacttcgatc catctgagct gccatagtgg accccactca gagctgcgtc 5761 cctcccttga ccccaggttg gtccctgcca ctcccctgcc cctgtcactg acacatgttt 5821 cctcctccct caggcaggag tgggacctcc cagcctcctc ctggggcctc cactcagaat 5881 gtcaggatga gcagggtcct aggaggcctc tggtgcagcc ttcccttccc accatccatg 5941 tgctcaaaga gaatcacccg tcctttcttg aatgccatgg atcatggggg atttgctgcc 6001 cacactccta ggcggcctct tagacatccg ttggtgccta acccaagcat cagtttggca 6061 gaggccgagt ccctcctctg tactggatac caagtcagct tccataggga tggggagaca 6121 cctggcccag ggaggagatg agaagcagcc cggatggtgc tacatatgtc agagagcagg 6181 gcaggaaggg atcagtgtgg ctgccaatgg tcaggagggc gccatggagt gaaccatggc 6241 ccctgcctcc tcaaccaaga agtcctctgg agctgatact caagaccccc cgtctctctc 6301 ctcaccctcc tctcccgctg cctcggctgg ctcaggtgtt cgatgcccgg gactgcaggt 6361 ctgcacagga aatgttcacc tacatctgca accacatcaa gtatgccacc aaccggggca 6421 accttcggtg agtgcccccc accatgccag gccccagcct tcttccccaa ggcagggaag 6481 gcggggctct gaccagctct ttccccatgc gtgccagctc ggccatcaca gtgttcccgc 6541 agcgctgccc tggccgagga gacttccgaa tctggaacag ccagctggtg cgctacgcgg 6601 gctaccggca gcaggacggc tctgtgcggg gggacccagc caacgtggag atcaccgagg 6661 tgggcaccga gggccaccca tgagggtgtc cccaaggtgg agaatgagga aaccagtggg 6721 agaaggctcg ggggatccag gcaggaagag gggagcctcg gtgagataaa ggatgaaaaa 6781 caccaaagga ggggtgcctg ggtggtcacg gagacccagc caatgaggga ccctggagat 6841 gaaggcagga gacagtggat ggaggggtcc ctgaggaggg catgaggctc agccccagaa 6901 ccccctctgg cccactcccc acagctctgc attcagcacg gctggacccc aggaaacggt 6961 cgcttcgacg tgctgcccct gctgctgcag gccccagatg agcccccaga actcttcctt 7021 ctgccccccg agctggtcct tgaggtgccc ctggagcacc ccacgtgagc accaaaggga 7081 ttgactgggt gggatggagg gggccatccc tgagcctctc aagaagggcc tgcaaggggg 7141 tgctgatccc acaccccaac acccccaggc tggagtggtt tgcagccctg ggcctgcgct 7201 ggtacgccct cccggcagtg tccaacatgc tgctggaaat tgggggcctg gagttccccg 7261 cagccccctt cagtggctgg tacatgagca ctgagatcgg cacgaggaac ctgtgtgacc 7321 ctcaccgcta caacatcctg gaggtgaggt gcgggatggg gctcgggcac cgaatgcacc 7381 tgtccaaggc aggagtctgg ctctcactcc atccccaaaa tgccagccac ggggacaatc 7441 agagcaggtc cagggttgcc tcctaaatgg gaactgagga caagctctag aaccactgaa 7501 gcaaaggggt agggggtggc aggggtgtgt gtgggggtgt gagtgggtga gtgtgagagt 7561 gtgggtttct ggggtgtgca gtgggtgaga gtgtgggctt gtggggtgtg tagtgggtgt 7621 gagactgtgg gtttgtaggg gtgggtgagt gtgggtgtgt gggggtaggt gggtgtgggt 7681 ttgtgggtgt gtataggcag tgactgtgag actgtgggtt tgtgggggta ggtgactgtg 7741 ggtttgtggg gtgtgtaggg gtgagtgtgt gtgggtttgt aggggtaggc gagtgtgggt 7801 ttgtggggtg tgtaggggtg agtgtgtgtg agtttgtagg ggtaggcgag tgtgggtttg 7861 tggggtgtgt aggggtgagt gtgtgtgagt ttgtaggggt aggtgagtgt gggtttgtgg 7921 ggtgtgtagg gggtgtgtgt gggcttgtag gggtaggcga gtgtgggttt gtggggtgtg 7981 taggggcgag tgtgagagtg taggtatgtg ggtgtgagtg tggatgtgtg taggcggtga 8041 gtgtgaaatt gtgggtttgt gggggtgggt gggtgtgagt gtgtgggttt gtgggtgggt 8101 gtgggtgtga gtgggtgggt gaggggggca tggggatggg tgtgaacatg tagttgttct 8161 ttcaggcata ggacccatag ctctagagct ttcatcagat tctcaaaggg gaccttgact 8221 cggaaaaggt taagacccat tttagagatg agaaattaaa gcctggagct gaggagcgac 8281 tggcccaaag tccctctctg ctctgaggtg cttcgcaggc aaaaacctga accagccccc 8341 taggcagcca ggcctcccaa tggacaccac tcacctcact ccttccagcc atgtacggga 8401 aacagagata gtctccccac cccacccccg tgatcacctc tgtccctacc gatgccacac WO 00/09525 PCT/US99/17712 EPT-109 1186 8461 acccttctgc cccaagatgt ggctgrctgc atagacctgg atacccagac cacctcatcc 8521 ctgtggaaag acaaggcaac agtggaaatc aacgtggccg tgccgcacag ttaccaggtg 8581 cagaggccca gactggccag gaaggcaaag ggtttgcata cgggggcagc aggggcgggg 8641 gatggaggag aggcagccat ttagaaacta gggcaggatt tggacagaca gaagaagttc 8701 cgtagtccca gtgccatagc gcacactggc tgcggttcgg ggacagggca ggtactattc 8761 caggcgctgt catctggtgg cttactgtgt gccagggacc ttgctgttta ctgcatgccc 8821 agtcatgctg attctcaggg catattgggt attgcagttt gtgggaccg ctggatcctg 8881 gaaacaaata ccaggatcaa gggcacacca ggagtcgtag tttgaggaag ccggggcctg 8941 ctgagaattt ctgtgggcta tttggtttgg ggaccaggca tgcagatgct ggagattaga 9001 gctgcttgtt gcatgttgaa cctgcagcat gaccatgcat gatgtggttt ggggtgaggg 9061 tgacattgtg gtttgagggg acacagggtg tgttagatat ggggtaatcg agggcacatg 9121 tggtttgggg tgaccggagt ggtggaggaa gaatgggcga ggtctgtggg tctggtttga 9181 gcctctcccc ctctctctcc cttccagcta gccaaagtca ccatcgtgga ccaccacgcc 9241 gccacggcct ctttcatgaa gcacctggag aatqagcaga aggccagggg gggctgccct 9301 gcagactggg cctggatcgt gccccccatc tcgggcagcc tcactcctgt tttccatcag 9361 gagatggtca actatttcct gtccccggcc ttccqctacc aggtgcccac cctaatggct 9421 ctgccagcct gggcccagct ctaattctaa gcagcccctg gggacctcta acctttcctt 9481 ttctttacct cccctcccaa ccccatcatc tctctgcagc cagacccctg gaaggggagt 9541 gccgccaagg gcaccggcat caccaggaag aagaccttta aagaagtggc caagtgggtc 9601 ccctgggagc cccgctctcc cacacacacc ctgggggccc cactctcccc cacacaccct 9661 gggggaccct gccccagcag tgttctggac ctaccactca gtatcccaaa accctgttgt 9721 gagggggttg gacccttgcc tggggaggcc ctgcctctgt gcacccggga caccctcaca 9781 ccttcctctc ccgcagcgcc gtgaagatct ccgcctcgct catgggcacg gtgatggcga 9841 agcgagtgaa ggcgacaagc ctgtatggct ccgagaccgg cctggcccag agctacgcac 9901 agcagctggg gagactcttc cggaaggctt ttgatccccg ggtagggctg agcccagggg 9961 agcagggagc tagaaagagg gggctctatc agcatcttca ggggtgccct ggaggacagg 10021 aagtgtaca agtcaggact cacgaggaac ccggaaccac aggtgttcag agatcaagtt 10081 ggggcctgaa tcttgcactg ccagggaggc cagagtgagg agggcagggc ctccgggggc 10141 cacagcaccc aggacatctg tcttcccacc cacaggtcct gtgtatggat gagtatgacg 10201 tggtgtccct cgaacacgag acgctggtgc tggtggtaac cagcacattt gggaatgggg 10261 atcccccgga gaatggagag gtgagaactt ccaggaaagg ggctgctggg aatgaggaga 10321 gactcagaat tggagtgact gggcaggaac ctctgcccaa cacacacaca cacacacaca 10381 cacacacaca cacacacaca cacacacaca cacacacaca cacacacaca cgccaggatg 10441 gaaagggaga tgctaagaga cccctggagc ctgaaacccc acacaacgta cgctcccagc 10501 ccacccatgt ggctgcctcc ctgcaagcac atttgcttaa ctgcgcgtcc ccaagtcatt 10561 tccattatca gtgcaagttt ttaatacaag gaaggcacat cctggctgac caagaggtta 10621 gactgtgctc gggcactgac aagaaaaaca gggatacgtc actgagggcg gcttctagga 10681 tgcgggtaat gtttcttaat gggatactgg ttacacaggt gtgttcagtt tgtaaaaatc 10741 cacagagctg tacatttaca acatgtacaa cactattcca gcattttatt ttatttgttt 10801 tatttatttt gataacctat ttacgttgcc caggctggcc ttgaactcct agcctcaaga 10861 gatcctcctg ccgcaggctc ctttttcaaa agaagaaatt gagcgctgtt tagatgccaa 10921 catagattaa ataacttcac tttttaaaaa gaaacacaaa gctagagtac catcattgaa 10981 ttccttctct tgcaagctta ggtatctctg aggtgcccca ggctaggctc atttctgagt 11041 ctaccctgcc ccagcttcta ggtgttaaag gccttattag cactaagtac ttcctcagta 11101 ctcttttttc ttttttcctt tgagacaggg tctcactttg tggcccaggc tggagtgcag 11161 tagtacaatc acggctcact gcagcctcaa cctcctagac tcaagcaatc ctcccacttc 11221 aacctcccaa gtagttggga ctacaggcgc atgccatgat gcctagctaa tttttgtatt 11281 ttttatagag atggggtttc gccatgttgc ccaggctggt ctctaactcc tgggttcaag 11341 caatccacct gcctcggcct cccaaagtgc tgcgattata gacgtgagcc actgcacctg 11401 gcccgcagta tcttaagcaa gttggaatct cgtgaaaccc tttttgctgc cttagtgtcc 11461 gtttcagccc cattcttac ctaccttttc aagaaaaata gcaccagcaa ttgacttttt 11521 tttagcataa aggtgtatag aacccatata acctacagcc ttcacaaggc atagcacatt 11581 ttcaccaccc tggaaattc cctcatcagt tcctcacgtg aatcccttcc cagtctgtct 11641 ccctgccaga agtgtctgtc accacagaat agtttcgcct gctctagaac ggcacctaga 11701 tggaagcacg cagtgttgcg cgtctcctg ctgaggctgt ttttgaggcg cactcgtgtt 11761 gctgcgtgac tcagtatttc actcattctg ctgctgagtg ccgttcattg tgtgaatatc 11821 cccagtttgt ttacccattc tcttgttggt gacacttggg ctgtttccag gtcggggcta 11881 ttatgaataa acctgttatg aacattctgt acccggcttt tgtgggctta tgtttttatt 11941 tctcttgggt aaaacctagg agtagaattg gtaggtcata gggtagatgc atgtttaatc 12001 tttcactttt ttaaaaaata aaactgccag gccaggcgcg gctgctcacg cctgtgatcc 12061 cagcactttg ggaggcccag gtgggtggat cacttgaggt cagaagctca agaccagcct 12121 ggccaacatg gcaaaaccct gtctctacta aaaatacaaa aattagctgg gcatggtggc 12181 gcacgcctat agtcctagct actcaggagg ctaggcggga gaattgcttg aacctgggag 12241 gtggaggttg cagtgagccg agatcacgcc actgcactcc agcctgggtg acagagcaag 12301 aattctactt aaaataaaat acaaataaat aaaataaaac tgtcaaacag caaagcaaa 12361 taaactgccc tttaacatct gtgcagttca atgtatgtta attttatccc aaatttttaa 12421 caaatctagg aatacagcc acagaaaatg gggtatattc accaaaaata aggaatattt 12481 atagcaaatt tgtttgtaat accccacact ggaaacaatt caaatgacca tcgacaaata WO 00/09525 PCT/US99/17712 EPI-109 1187 12541 ctgataaatt gtggtatatt caagtgccat atcgcactaa gtgtgaacga aacacaacca 12601 cacacaacag tgcaggtgaa tctgaaaaaa tgtgaagaga agaaaaagcc agaccaaaga 12661 atacatactg tactacaggg ttcactttat ataaagttca gaaacaggca gaactaatcc 12721 acggagttag aaattaggag aggagttagt cactgggatg ggggtggcag tgacaggaag 12781 aaggcacgaa gttggcttct aggatgcggg taatgtttgt ttgtttgttt gtttgtttgt 12841 ttttgttttt gagctggagt ctcactctgt tgcccaggct ggagtgcaat ggcgtgatct 12901 cggctcactg caacctccgc ctccccggtt caagcgattc tcctgcctca gcctcccgag 12961 tagctgggat tacaggtgcc cgccaccatg gccagctaat ttttgtgttt ttagtagaga 13021 cgcgtttcac catgttggcc aggctggtct tgaatccctg acctcagcct cccaaagtgc 13081 tgggattaca ggcgtgagcc accacgccca gccacgggta atgtttctcg atgggatgct 13141 ggttgcacag gtgtgttcag tttgtgaaaa cttacagagt tgtacattta caacatgtgt 13201 gcacctctgg acttgtgttg cacgttgaca aaacattcaa aaatgaaatt caaatcgttc 13261 ttgctaactc tggcgcactt gggaaccagc acccagaggc atctgcagtt gagcaccaga 13321 tgcagttcct tccagcttcc ttccccctgg gaggtccgct tgatgccact tcttcatggc 13381 agcacaaaca aggccatggt cttctgagga gggcaacctg cacaatgtct gctagtgacc 13441 aggacactgc tgaaggaact gagagtttgt ccacccatga aatccactaa aacaggaaag 13501 attttgctct agccgttgtt agccaggagt gaggaaagag ctgtgccctc ccctgcagct 13561 gcgaggacga tctgcctgcc ccaacaagtg gggattcagc aactccactt ctaaggatta 13621 cccagctgaa gcatttaaaa gtgggagcaa ggcacacgta caagggcgtt tgagagagca 13681 cctgttccca gaccaccgag ctgcccttca gtctcagtga agtacaatgt agccactaaa 13741 aagactgagg tcatgttttg gaaagtccag gccggaggat cgcttgagcc caggagttca 13801 aggccagact gaacaacaca gcgagactcc atctcttcag aaaatttaaa aattaaccaa 13861 gagtggtggc acgcacctat agatctagct actaggaagg cagaaaaatc ccttaagccc 13921 aggagtttga ggttacagtg aatgatgatg gagccactgc accccaacct gggcgacaga 13981 gcaagaccca tatctaaaaa caatactact acttacgtca atattgttgt attgacctgg 14041 agggatgtct gcaataaatt attgattaaa accaaggaag tacagtatgg taccactttt 14101 acttaaaaaa aaactataaa tatgcacgtg cacgtaagtt caaggaaaaa gggctggaag 14161 gttaacacct gtgaatggcg catatgcccg gaggaagatg gggtggtctt tgtcttatca 14221 ctttacacat ttctgtaatg tcatttttca aaaacatcag atcgcttttg aaattttcaa 14281 aacaaataaa aattaagtga caaatcaata ataatgagga tcagctggta cagttttaaa 14341 cttctatgta gtttgaaatg aaacaaaact aaccctgatg caaacactcc cctcgccaga 14401 gctttgcagc tgccctgatg gagatgtccg gcccctacaa cagctcccct cggccggaac 14461 agcacaagtg agttgggtga gagtttgggg gagctggggg agctgatgca tttggagaca 14521 caaacagaaa gggggtctga aaagctctcc ctctgtgcct caagtcgttt tcccaccaaa 14581 agccagggct ccaggatgcc ctccattcca ggctgcaatg gcagtccaga cctgcctgct 14641 tctgagagcc gggacagtcc tgaggtcttc agagatgggg gtgtggtgtg tcagggcccc 14701 aggctcggaa ccccagggat gctggccctc agcccctccc aagggcaggg cctttcctgt 14761 ccagaggcag agaccctgaa gccgtccctg gggctgggtc tgggcctagc ctgtatcccc 14821 agggccctgt gacaaccttg tctttgtcct ctcttgccag gagttataag atccgcttca 14881 acagcatctc ctgctcagac ccactggtgt cctcttggcg gcggaagagg aaggagtcca 14941 gtaacacaga cagtgcaggg gccctgggca ccctcaggtc agggcctcac caagaggggt 15001 gcaacgggtg ggcaagctgc ctgggcaaac gtggcctgca aagggagctc cactgacgac 15061 ccctgcaccc caggttctgt gtgttcgggc tcggctcccg ggcatacccc cacttctgcg 15121 cctttgctcg tgcggtggac acacggctgg aggaactggg cggggagcgg ctgctgcagc 15181 tgggccaggg cgacgagctg tgcggccagg aggaggcctt ccgaggctgg gcccaggctg 15241 ccttccaggt gagcccagcc cagcccctgc tctgactcct gccccctggg atgcctcctc 15301 ctgcctcact ctgccctgat tctgtttggt tctttggtcc cttcctgttc cttccaaaat 15361 ccaccctcat ctctccatgg catagccagc tcttctgggt caggggcaga ggatgacatg 15421 gccctgccga ccacaggggt gcctagccca ggcagaagtg cagccgaaag agagcaggca 15481 gggccctggc aggagggagc ttcagccagg cacaggctgg gcctcacaag tgggcgcaca 15541 aagggagggg gtgcagggca gggcagggga ccccacccag gatgggcagg atggagggag 15601 aaggaaggga cagagagaag gtcagacaga ggcaagggct gaagctgagg ccagcacaga 15661 agccacagga agccagaggc cagacagcct ggggcggtgc ctgcaccaga actggtccgg 15721 gccaggcaag caagcacagg gagaggtgga tccctggggg ctgtggcttt ttaagcctgg 15781 gcttcctcag gggcagtgct gcctgtctgg ggatcatgtc tgcagttgac aagggctcgg 15841 tctccccagt gccacactgt tcagggcagt gctgctgtcc cggggcccag gctggagctc 15901 agcagatttg ccttgattgg aggaggaggg catcctagga ggagagggag tgggggctac 15961 ctcagggacg gggaggtcag gctgcagaaa cacataggcc ctgattggga agaagggaca 16021 cggtaaaata agctctaaaa gaatttaaaa caaaaagagc cattgcagcg ggatgagacc 16081 acatcatcag gttttgggaa taggacttta gaggcgtagg atccattaca gcatcaccga 16141 accagaagca ggaaggctga gctaagcaga gcagcagcag tggagatagg aaggaaggga 16201 gggaggggcc gaggaaggaa ggaagagata taagacttca cacgcaccac aaaagaaaga 16261 ttaacgggac ttggtgatat gaggctcagc caatcacggg tgagccctgc atttcaagcc 16321 tgggactggc ccagcagttt tccagctgtg tgcctgacca ggagtagacg ggatccacac 16381 cctcccaggg atctgccccg tggggtcccc tctgccgccc gaattgtgcg tcccttccca 16441 ggagcactta ctatctgcac gcactttgtg gaaagctaag ggctttacat aaagtatctc 16501 atttaatctt caccagaaca caatgaggtg taaagatggg gaaactgagg catgtcactg 16561 taagtacggg attcggaatt tgaatgcagg tctgaacaca cagacgcctt cacagagcta WO 00/09525 PCT/US99/17712 EPI-109 1188 16621 ccgtgtgcca agcactatgc ttctcggatc acgggattaa cacgcaccag ataaggaacg 16681 atgcaccaat caggacgtgc agagaaagag ccaaccgggt ccctgggccc agcggccaat 16741 ccatgaaatg ggctggcgga aaaggtgctg tccttggcgc cggcctcagc cactggggct 16801 gccaaccccc caggagcaag acgcagtgaa gccgcccagg cgcctcacta gggcgacccc 16861 tggtggcggg aggtcctcag ccctcaccgg cctgtcccgc aggccgcctg tgagaccttc 16921 tgtgtgggag aggatgccaa ggccgccgcc cgagacatct tcagccccaa acggagctgg 16981 aagcgccaga ggtaccggct gagcgcccag gccgagggcc tgcagttgct gccaggtggg 17041 ccctgcctca ccctaacccg gctggttctc tgaggccccc acaccccggg actaaagcac 17101 tctggggcca ggccctgctc cctagctcag gctgcctcat ttgcccctcc ccgcccccag 17161 gtctgatcca cgtgcacagg cggaagatgt tccaggctac aatccgctca gtggaaaacc 17221 tgcaaagcag caagtccacg tgaggacgac ggctttaccg ccccccaacc cctgtcctga 17281 acaccctgac cctggaccct cctcctccca cattctcccg cccccacccc tctctgactc 17341 cccataagtg cccctctccc cacccccagg agggccacca tcctggtgcg cctggacacc 17401 ggaggccagg aggggctgca gtaccagccg ggggaccaca taggtgtctg cccgcccaac 17461 cggcccggcc ttgtggaggc gctgctgagc cgcgtggagg acccgccggc gcccactgag 17521 cccgtggcag tagagcagct ggagaagggc agccctggtg aggggcagcc tgggaagcaa 17581 cagggcacac cagccccatg cccagcccca cccccggccc caggcctcca ggagctcagg 17641 acccgaccca gggggtggcc acctcctcca cagctcagca ggcaggctca gagctggctg 17701 tgctgcccac tgccgggctg gccttgttgc tggaccatcc ccacaccctc aaatgcaccc 17761 ccaccaaaag gctgtcccct ccctctgggc tcctctccaa ggctccccta gcaatctagc 17821 ttgctctgga gctggcactg gggctatttg ctgccacatc aatgcctggg ctttatttaa 17881 aataaggggg tggagtcaga ggcagaggag cccagaccaa cccagtccgg ccaggggccc 17941 ccgaacaata cactgaggct acctagacag gccgaccccg ctgctcaagg gcaggctctc 18001 taacagtcac caaaacacaa acatcagccc aggtactgca gtcctgctgg gccctgtcct 18061 cagagctccc tgtgcactat ccccaggtgg ccctcccccc ggctgggtgc gggacccccg 18121 gctgcccccg tgcacgctgc gccaggctct caccttcttc ctggacatca cctccccacc 18181 cagccctcag ctcttgcggc tgctcagcac cttggcagaa gagcccaggg aacagcagga 18241 gctggaggcc ctcagccagg ttgggggcca ccccaatgag gcacaggggc tagagagacg 18301 ggatgagctg gggggacccc agtggcagga aacccccatg caaagtcccc cctggacttt 18361 cttctcctgg ctgacatgca ctggtgcttt aagacccagc tcctcaggga ggaattcatg 18421 gctggattct ccaggtctta gagaaaactc tattggcctg aactgagcag ggagaaaccc 18481 taaagaggct cagtggggga ggggtcaaga agggaggtta ctaggaaggg ctatggggcc 18541 tccaacccac tgcatcctgc cccgccagga tccccgacgc tacgaggagt ggaagtggtt 18601 ccgctgcccc acgctgctgg aggtgctgga gcagttcccg tcggtggcgc tgcctgcccc 18661 actgctcctc acccagctgc ctctgctcca gccccggtac tactcagtca gctcggcacc 18721 cagcacccac ccaggagaga tccacctcac tgtagctgtg ctggcataca ggactcaggg 18781 tgaggcaaca agcaggagca ggcctggcca cagcagggtt gggaccggcc cctctctggc 18841 ccctcaccgg cctctccttc ccacccccag atgggctggg ccccctgcac tatggagtct 18901 gctccacgtg gctaagccag ctcaagcccg gagaccctgt gccctgcttc atccgggggt 18961 aagtgagatg gaggacttgg tggggagctg cccagggtca gggtggcagc tttggtgagg 19021 agtgtcactg gtgaggggtg tcactggaaa caggaaggag ctctgtaaca tgtcaagggt 19081 gtggtgtcat taggtcactt cagaactctg gctaagcttt ggctctctca ttcatttaga 19141 ctcagagttc tgccctgaaa ctatagctcc cagagccaga gctggtatca aaccggctgg 19201 ccctgtggct ttctgaaagc ttctgtgttc ctctctatgt ccctgggctg tctgatgttg 19261 ggcagcatgg cacctgggaa ctacagtcac taaatcctca ctcaatccag ggagaactac 19321 tagttagggt taagaccacc ctttggcctt ggtgtcacca aggactcaaa gaaggtgaag 19381 gttttggttt ttttttcccc cagagatgga gtcttgctct gtcgcccagg ctggagtgca 19441 gtggtacgat ctcggcttac tgcaacctcc gcctcccggg ttcaagagat tctcctatgg 19501 cgtgaacctg ggaggtggag cttgcagtga gccaagattg tcccactgca ctccagcctg 19561 ggcgacagag ccagactctg tctcaaaaaa aaaaaaaaaa tattctcctg tctcagcctc 19621 ctgagtagct gggattacag gcacccacca ccacgcccag ctaatttttg tatttttagt 19681 agagacggtg tttcactatg ttggccaggc tggtctcgag ctcctgacct cacaatcctc 19741 ccacctccgc ctcccaaagt cttgggatta caggtgtgag ccaccgcgcc cggaccgagg 19801 gtgaaggatt ttaagagacc cttccttcat gctgtgtcca gaagtcttgc ccgctctcgc 19861 agccaggaac caaaagtcct ggtaggactg agaacagttc ctaggctgcc atcagctggg 19921 cctggtgatt caaatccacc caggtggcta aactacaaat aaaccgtacc catctactga 19981 acataaacta aataccacta ttaaggatac ttaaaataaa cacacttagt gaacccatta 20041 tgaactgaaa gtgtctttca cccttcccac gttttctaaa tcccctgagt catctaagta 20101 ttcttcaatc caaaatgaac tatatttcct ttggtgcaat ctccagaaac cacagatcca 20161 aggagtttca gcaagtagag ttgttttttg ttttttgttt tttttttaat ttttttttga 20221 gatgggaaga acttgggtcc tccttgctcc acccaccctg catggtgaga atggtggagc 20281 aggaaaggca aaggggacct gatggagtgt ctctcctgcc agggctccct ccttccggct 20341 gccacccgat cccagcttgc cctgcatcct ggtgggtcca ggcactggca ttgccccctt 20401 ccggggattc tggcaggagc ggctgcatga cattgagagc aaaggtgagg ctggtgacta 20461 aaggactgcc tgaagggagt cacacaatct agggacagag gggtggggct ggaaggcagg 20521 aaataggaaa gagagggcag gaaacaaagt ccacaaagct gaaaagacgc tcatgagacc 20581 aaggggaggg caggtaccaa aggcaagggc tgggccctga gcttctggct tcctggtgcc 20641 tggtacatag taggtgttga ctggattgag gacaaaggaa aatagaattt tcaaagggat WO 00/09525 PCT/US99/17712 EPI-109 1189 20701 tagggctaag actcaaagaa gaactgccca aggtggatc ttgacgtgc gac 20761 cgaggtctat ccaagaccta aagatgctac aaggtgttca tatzgagcat cagagctga 20821 gggtggtctg tcaatcaaaa aaagagggct gtgactggga tagagcat ggggtgccca 20881 gaatatgaag tgggagcggg gaaggggact gcgatgtcac acaatgcaaa gggcatggaa 20941 ttctgagtcc gaagccgacgc attctagcgc actccaccag gggccaccac ctcacccgcg 21001 cttcccttcc ctctgtaaa cagggctgtg cagggtctct gtgaaagcat tctacactct 21061 cttagagatg aaacagccaa agtaatggtg gtttcagccc aaaacgctgg gctgccaggc 21121 tgggcgacgg tggcctatgg ggaggcccca ctagcactgt gccccggaga agagccttcc 21181 caagcgcggg gtgcttgca gggctgcagc ccactcccat gactttggtg ttcggctgcc 21241 gatgctccca acttgaccat ctctaccgcg acgaggtgca gaacgcccag cagcgcgggg 21301 tgtttggccg agtcctcacc gcctctccc gggaacctga caaccccaag gtgtgagacc 21361 ctgagggcgc aatggaacc tgaagatagg gagagagggg aggactcgcg ctctccagcg 21421 gggcacacca accacggccc tcccgtggcc tcccacgacc actcagccac ccctgcacac 21481 tctggcccac ccttgtgccc cggcccctct aggccccgcc tcctcccgcc cctgccccgc 21541 ccctttggct ctgccctgtt gacaacgccc cagggcacgc aggccccacc aggcccgctc 21601 cggagaattt caaggtccag ggccagccag cagccccggg ctgcccccgc gcccaccccc 21661 accagggccc gccctaaccc cgccgccccg cagacctacg tgcaggacat cctgaggacg 21721 gagctggctg cggaggtgca ccgcgtgctg tgcctcgagc ggggccacat gtttgtctgc 21781 ggcgatgtta ccatggcaac caacgtcctg cagaccgtgc agcgcatcct ggcgacggag 21841 ggcgacatgg agctggacga ggccggcgac gtcatcggcg tgctgcgggt gcggaggggc 21901 gggccgggcc tgagcgtgcg gggttcctgc taaggtctcc gagtcgggtt ctgatccact 21961 gtgctctttt ccgacaggat cagcaacgct accacgaaga cattttcggg ctcacgctgc 22021 gcacccagga ggtgacaagc cgcatacgca cccagagctt ttccttgcag gagcgtcagt 22081 tgcggggcgc agtgccctgg gcgttcgacc ctcccggctc agacaccaac agcccctgag 22141 agccgcctgg ctttcccttc cagttccggg agagcggctg cccgactcag gtccgcccga 22201 ccaggatcag ccccgctcct ccctcttga ggtggtgcct tctcacatct gtccagaggc 22261 tgcaaggatt cagcattatt cctccaggaa ggagcaaaac gcctcttttc cctctctagg 22321 cctgttgcct cgggcctggg tccgccttaa tctggaaggc ccctcccagc agcggtaccc 22381 cagggcctac tgccacccgc ttcctgtttc ttagtcgaat gttagattcc tcttgcctct 22441 ctcaggagta tcttacctgt aaaqtctaat ctctaaatca agtatttatt attgaagatt 22501 taccataagg gactgtgcca gatgttagga gaactactaa agtgcctacc ccaqctcatg 22561 tggattacag tttttttttt ttgttttttt ttttttgaaa cggagtctcc ctctgccgcc 22621 cgggctggag tgcagtggcg tgatctcagc tcactgcaac ctccacccca caagttcaag 22681 tgattctcct gcctcagcct cccaagtagt tgggattaca ggtgcctgcc accgcgcccg 22741 gctaggtttt gtatttttag taaagacggg gtttcaccat cttggccagg ctggtcttga 22801 actcctgacc tcgtgatcca accgcctcag cctcccaaag tgctgggatt acaggtgtga 22861 gctactgcac ccggcgtgga ttacaattat aaaatgacaa gatttctgtt ttaacctgtg 22921 cagttgtggg tatgtggtgg ggaaaggggt cattctttta acagagtcct acacgccact 22981 tgaccctgca ctctgaaaac atggtttcca gccagtctgg gctgctcccc cgtgcagttc 23041 tcaggctcgt aatcgagaag gcaggtgcag cactcagctg ccaqgagtgg ggcctgccag 23101 aaacaagagt cacagagatg tgcaacagcc atgagcaagc tt 1 cagagtggac gcacagtaac atgggcaact tgaagagcgt ggcccaggag gctgggccac 61 cctgcggcct ggggctgggg ctgggccttg ggctgtgcgg caagcagggc ccagccacct 121 cggcccctga gcccagccgg gccccagcat ccctactccc accagcgcca gaacacagcc 181 ccccgagctc cccgctaacc cagcccccag aggggcccaa gttccctcgt gtgaagaact 241 gggaggtggg gagcatcacc tatgacaccc tcagcgccca ggcgcagcag gatgggccct 301 gcaccccaag acgctgcctg ggctccctgg tatttccacg gaaactacag ggccggccct 361 cccccggccc cccggcccct gagcagctgc tgagtcaggc ccgggacttc atcaaccagt 421 actacagctc cattaagagg agcggctccc aggcccacga acagcggctt caagaggtgg 481 aagccgaggt ggcagccaca ggcacctacc agcttaggga gagcgagctg gtgttcgggg 541 ctaagcaggc ctggcgcaac gctccccgct gcgtgggccg gatccagtgg gggaagctgc 601 aggtgttcga tgcccgggac tgcaggtctg cacaggaaat gttcacctac atctgcaacc 661 acatcaagta tgccaccaac cggggcaacc ttcgctcggc catcacagtg ttcccgcagc 721 gctgccctgg ccgaggagac ttccgaatct ggaacaqcca gctggtgcgc tacgcgggct 781 accggcagca ggacggctct gtgcgggggg acccagccaa cgtggagatc accgagctct 841 gcattcagca cggctggacc ccaggaaacg gtcgcttcga cgtgctgccc ctgctgctgc 901 aggccccaga tgagccccca gaactcttcc ttctgccccc cgagctggtc cttgaggtgc 961 ccctggagca ccccacgctg gagtggtttg cagccctggg cctgcgctgg tacgccCtcc 1021 cggcagtgtc caacatgctg ctggaaattg ggggcctgga gttccccgca gcccccttca 1081 gtggctggta catgagcact gagatcggca cgaggaacct gtgtgaccct caccgctaca 1141 acatcctgga ggatgtggct gtctgcatgg acctggatac ccggaccacc tcgtccctgt 1201 ggaaagacaa ggcagcagtg gaaatcaacg tggccgtgct gcacagttac cagctagcca 1261 aagtcaccat cgtggaccac cacgccgcca cggcctcttt catgaagcac ctggagaatg 1321 agcagaaggc cagggggggc tgccctgcag actgggcctg gatcgtgccc cccatctcgg 1381 gcagcctcac tcctgttttc catcaggaga tggtcaacta tttcctgtcc ccggccttcc 1441 gctaccagcc agacccctgg aaggggagtg ccgccaaggg caccggcatc accaggaaga 1501 agacctttaa agaagtggcc aacgccgtga aaatctccgc ctcgctcatg ggcacggtga 1561 tggcgaagcg agtgaaggcg acaatcctgt atggctccga gaccggccgg gcccagagct WO 00/09525 PCT/US99/17712 EPI-109 1190 1621 acgcacagca gctggggaga ctcttccgga aggcttttga tccccggtc ztgtgtatgg 1681 atgagtatga cgtggtgtcc ctcgaacacg agacgctggt gczggtagta accagcacat 1741 ttgggaatgg ggatcccccg gagaatggag agagctttgc agctgccctg atggagatgt 1801 ccggccccta caacagctcc cctcggccgg aacagcacaa gagttataag atccgcttca 1861 acagcatctc ctgctcagac ccactggtgt cctcttggcg gcggaagagg aaggagtcca 1921 gtaacacaga cagtgcaggg gccctgggca ccctcaggtt ctgtgtgttc gggctcggct 1981 cccgggcata cccccacttc tgcgcctttg ctcgtgccgt ggacacacgg ctggaggaac 2041 tgggcgggga gcggctgctg cagctgggcc agggcgacga gctgtgcggc caggaggagg 2101 ccttccgagg ctgggcccag gctgccttcc aggccgcctg tgagaccttc tgtgtgggag 2161 aggatgccaa ggccgccgcc cgagacatct tcagccccaa acggagctgg aagcgccaga 2221 ggtaccggct gagcgcccag gccgagggcc tgcagttgct gccaggtctg atccacgtgc 2281 acaggcggaa gatgttccag gctacaatcc gctcagtgga aaacctgcaa agcagcaagt 2341 ccacgagggc caccatcctg gtgcgcctgg acaccggagg ccaggagggg ctgcagtacc 2401 agccggggga ccacataggt gtctgcccgc ccaaccggcc cggccttgtg gaggcgctgc 2461 tgagccgcgt ggaggacccg ccggcgccca ctgagcccgt ggcagtagag cagctggaga 2521 agggcagccc tggtggccct ccccccggct gggtgcggga cccccggctg cccccgtgca 2581 cgctgcgcca ggctctcacc ttcttcctgg acatcacctc cccacccagc cctcagctct 2641 tgcggctgct cagcaccttg gcagaagagc ccagggaaca gcaggagctg gaggccctca 2701 gccaggatcc ccgacgctac gaggagtgga agtggttccg ctgccCacg ctgctggagg 2761 tgctggagca gttcccgtcg gtggcgctgc ctgccccact gctcctcacc cagctgcctc 2821 tgctccagcc ccggtactac tcagtcagct cggcacccag cacccaccca ggagagatcc 2881 acctcactgt agctgtgctg gcatacagga ctcaggatgg gctgggcccc ctgcactatg 2941 gagtctgctc cacgtggcta agccagctca agcccggaga ccctgtgccc tgcttcatcc 3001 ggggggctcc ctccttccgg ctgccacccg atcccagctt gccctgcatt ctggtgggtc 3061 caggcactgg cattgccccc ttccggggat tctggcagga gcggctgcat gacattgaga 3121 gcaaagggct gcagcccact cccatgactt tggtgttcgg ctgccgatgc tcccaacttg 3181 accatctcta ccgcgacgag gtgcagaacg cccagcagcg cggggtgttt ggccgagtcc 3241 tcaccgcctt ctcccgggaa cctgacaacc ccaagaccta cgtgcaggac atcctgagga 3301 cggagctggc tgcggaggtg caccgcgtgc tgtgcctcga gcggggccac atgtttgtct 3361 gcggcgatgt taccatggca accaacgtcc tgcagaccgt gcagcgcatc ctggcgacgg 3421 agggcgacat ggagctggac gaggccggcg acgtcatcgg cgtgctgcgg gatcagcaac 3481 gctaccacga agacattttc gggctcacgc tgcgcaccca ggaggtgaca agccgcatac 3541 gcacccagag cttttccttg caggagcgtc agttgcgggg cgcagtgccc tgggcgttcg 3601 accctcccgg ctcagacacc aacagcccct gagagccgcc tggctttccc ttccagttcc 3661 gggagagcgg ctgcccgact caggtccgcc (2) INFORMATION FOR SEQ ID NO:35: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1872 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:35: aggagtttcg acccgcgctg gcgagtcatg agcgccaagt ttcccactgg cgcgcaaact 61 tgagttactt ttgagcgtgg atactggcga agaggctgcg ggcggtatta gcgtttgcag 121 cgacttggct cgggcagctg acccaagtgt cctgtcttcc ttcctctgct tgtctctagg 181 ctctgaaact gcggagcggc caccggacgc cttctggagc aggtagcagc atgcagccgc 241 ctccaagtct gtgcggaccg gccctggttg cgctggttct tgcctgcggc ctgtcgcgga 301 tctggggaga ggagagaggc ttcccgcctg acagggccac tccgcttttg caaaccgcag 361 agataatgac gccacccact aagaccttat ggcccaaggg ttccaacgcc agtctggcgc 421 ggtcgttggc acctgcggag gtgcctaaag gagacaggac ggcaggatct ccgccacgca 481 ccatctcccc tcccccgtgc caaggaccca tcgagatcaa ggagactttc aaatacatca 541 acacggttgt gtcctgcctt gtgttcgtgc tggggatcat cgggaactcc acacttctga 601 gaattatcta caagaacaag tgcatgcgaa acggtcccaa tatcttgatc gccagcttgg 661 ctctgggaga cctgctgcac atcgtcattg acatccctat caatgtctac aagctgctgg 721 cagaggactg gccatttgga gctgagatgt gtaagctggt gcctttcata cagaaagcct 781 ccgtgggaat cactgtgctg agtctatgtg ctctgagtat tgacagatat cgagctgttg 841 cttcttggag tagaattaaa ggaattgggg ttccaaaatg gacagcagta gaaattgttt 901 tgatttgggt ggtctctgtg gttctggctg tccctgaagc cataggtttt gatataatta 961 cgatggacta caaaggaagt tatctgcgaa tctgcttgct tcatcccgtt cagaagacag 1021 ctttcatgca gttttacaag acagcaaaag attggtggct attcagtttc tatttctgct 1081 tgccattggc catcactgca tttttttata cactaatgac ctgtgaaatg ttgagaaaga 1141 aaagtggcat gcagattgct ttaaatgatc acctaaagca gagacgggaa gtggccaaaa 1201 ccgtcttttg cctggtcctt gtctttgccc tctgctggct tccccttcac ctcagcagga 1261 ttctgaagct cactctttat aatcagaatg atcccaatag atgtgaactt ttgagctttc 1321 tgttggtatt ggactatatt ggtatcaaca tggcttcact gaattcctgc attaacccaa 1381 ttgctctgta tttggtgagc aaaagattca aaaactgctt taagtcagc ttatgctgct 1441 ggtgccagtc atttgaagaa aaacagtcct tggaggaaaa gcatcgtgc ttaaagttca 1501 aagctaatga tcacggatat gacaacttcc gttccagtaa taaatacagc tcatcttgaa WO 00/09525 PCTIUS99/17712 EPI-109 1191 1561 aaaagaacra ztcactgrat ttcattttcz tratattgga ccgaagtcat taaaacaaaa 1621 tgaaacatcc gccaaaacaa aacaaaaaac tatgtatttg cacaacacac tattaaaata 1681 ttaatgtaa ztattttaac actcacagct acatatgaca ttttatgagc tgtttacggc 1741 atggaaagaa aatcagtggg aattaagaaa gcctcgtcgt gaaagcactt aattttttac 1801 agttagcac: ccaacatagc tcttaacaac ttccaggata ttcacacaac acttaggctt 1861 aaaaatgagc tc (2) INFORMATION FOR SEQ ID NO:36: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 4286 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:36: 1 gagacattcc ggtgggggac tctggccagc ccgagcaacg tggatcctga gagcactccc 61 aggraggcat ttgccccggt gggacgcctt gccagagcag tgtgtggcag gcccccgtgg 121 aggatcaaca cagtggctga acactgggaa ggaactggta cttggagtct ggacatctga 181 aacttggctc tgaaactgcg cagcggccac cggacgcctt ctggagcagg tagcagcatg 241 cagccgcctc caagtctgtg cggacgcgcc ctggttgcgc tggttcttgc ctgcggcctg 301 tcgcggatct ggggagagga gagaggcttc ccgcctgaca gggccactcc gcttttgcaa 361 accgcagaga taatgacgcc acccactaag accttatggc ccaagggttc caacgccagt 421 ctggcgcggt cgttggcacc tgcggaggtg cctaaaggag acaggacggc aggatctccg 481 ccacgcacca tctcccctcc cccgtgccaa ggacccatcg agatcaagga gactttcaaa 541 tacatcaaca cggttgtgtc ctgccttgtg ttcgtgctgg ggatcatcgg gaactccaca 601 cttctgagaa rtatctacaa gaacaagtgc atgcgaaacg gtcccaatat cttgatcgcc 661 agcttggctc tgggagacct gctgcacatc gtcattgaca tccctatcaa tgtctacaag 721 ctgctggcag aggactggcc atttggagct gagatgtgta agctggtgcc tttcatacag 781 aaagcctccg tgggaatcac tgtgctgagt ctatgtgctc tgagtattga cagatatcga 841 gctgttgctt cttggagtag aattaaagga attggggttc caaaatggac agcagtagaa 901 attgttttga tttgggtggt ctctgtggtt ctggctgtcc ctgaagccat aggttttgat 961 ataattacga tggactacaa aggaagttat ctgcgaatct gcttgcttca tcccgttcag 1021 aagacagctt tcatgcagtt ttacaagaca gcaaaagatt ggtggctgtt cagtttctat 1081 ttctgcttgc cattggccat cactgcattt ttttatacac taatgacctg tgaaatgttg 1141 agaaagaaaa gtggcatgca gattgcttta aatgatcacc taaagcagag acgggaagtg 1201 gccaaaaccg tcttttgcct ggtccttgtc tttgccctct gctggcttcc ccttcacctc 1261 agcaggattc tgaagctcac tctttataat cagaatgatc ccaatagatg tgaacttttg 1321 agctttctgt tggtattgga ctatattggt atcaacatgg cttcactgaa ttcctgcatt 1381 aacccaattg ctctgtattt ggtgagcaaa agattcaaaa actgctttaa gtcatgctta 1441 tgctgctggt gccagtcatt tgaagaaaaa cagtccttgg aggaaaagca gtcgtgctta 1501 aagttcaaag ctaatgatca cggatatgac aacttccgtt ccagtaataa atacagctca 1561 tcttgaaaga agaactattc actgtatttc attttcttta tattggaccg aagtcattaa 1621 aacaaaatga aacatttgcc aaaacaaaac aaaaaactat gtatttgcac agcacactat 1681 taaaatatta agtgtaatta ttttaacact cacagctaca tatgacatti tatgagctgt 1741 ttacggcata gaaagaaaat cagtgggaat taagaaagcc tcgtcgtgaa agcacttaat 1801 tttttacagt tagcacttca acatagctct taacaacttc caggatattc acacaacact 1861 taggcttaaa aatgagctca ctcagaattt ctattctttc taaaaagaga tttattttta 1921 aatcaatggg actctgatat aaaggaagaa taagtcactg taaaacagaa cttttaaatg 1981 aagcttaaat tactcaattt aaaattttaa aatcctttaa aacaactttt caattaatat 2041 tatcacacta ttatcagatt gtaattagat gcaaatgaga gagcagttta gttgttgcat 2101 ttttcggaca ctggaaacat ttaaatgatc aggagggagt aacagaaaga gcaaggctgt 2161 ttttgaaaat cattacactt tcactagaag cccaaacctc agcattctgc aatatgtaac 2221 caacatgtca caaacaagca gcatgtaaca gactggcaca tgtgccagct gaatttaaaa 2281 tataatactt ttaaaaagaa aattattaca tcctttacat tcagttaaga tcaaacctca 2341 caaagagaaa tagaatgttt gaaaggctat cccaaaagac ttttttgaat ctgtcattca 2401 cataccctgt gaagacaata ctatctacaa ttttttcagg attattaaaa tcttcttttt 2461 tcactatcgt agcttaaact ctgtttggtt ttgtcatctg taaatactta cctacataca 2521 ctgcatgtag atgattaaat gagggcaggc cctgtgctca tagctttacg atggagagat 2581 gccagtgacc tcataataaa gactgtgaac tgcctggtgc agtgtccaca tgacaaaggg 2641 gcaggtagca ccctctctca cccatgctgt ggttaaaatg gtttctagca tatgtataat 2701 gctatagtta aaatactatt tttcaaaatc atacagatta gtacatttaa cagctacctg 2761 taaagcttat tactaatttt tgtattattt ttgtaaatag ccaatagaaa agtttgcttg 2821 acatggtgct tttctttcat ctagaggcaa aactgctttt tgagaccgta agaacctctt 2881 agctttgtgc gttcctgcct aatttttata tcttctaagc aaagtgcctt aggatagctt 2941 gggatgagar gtgtgtgaaa gtatgtacaa gagaaaacgg aagagagagg aaatgaggtg 3001 gggttggagg aaacccatgg ggacagattc ccattcttag cctaacgttc gtcattgcct 3061 cgtcacatca atgcaaaagg tcctgatttt gttccagcaa aacacagtgc aatgttctca 3121 gagtgacttz cgaaataaat tgggcccaag agctttaact cggtcttaaa atatgcccaa 3181 atttttactt tgtttttctt ttaataggct gggccacatg ttggaaataa gctagtaatg 3241 ttgttttct ctaatattga atgtgaggt acagtaaacc aaaacccaac aatgtggcca WO 00/09525 PCT/US99/17712 EPI-109 1192 3301 gaaagaaaga gcaataataa ttaattcaca caccatatgg attctattta taaatcaccc 3361 acaaacttgt tctttaattt catcccaatc actttttcag aggcctgtta tcatagaagt 3421 cattttagac tctcaatttt aaattaattt tgaatcacta atattttcac agtttattaa 3481 tatatttaat ttctatttaa attttagatt atttttatta ccatgtactg aatttttaca 3541 tcctgatacc ctttccttct ccatgtcagt atcatgttct ctaattatct tgccaaattt 3601 tgaaactaca cacaaaaagc atacttgcat tatttataat aaaattgcat tcagtggctt 3661 tttaaaaaaa atgtttgatt caaaacttta acatactgat aagtaagaaa caattataat 3721 ttctttacat actcaaaacc aagatagaaa aaggtgctat cgttcaactt caaaacatgt 3781 ttcctagtat taaggacttt aatatagcaa cagacaaaat tattgttaac atggatgtta 3841 cagctcaaaa gatttataaa agattttaac ctattttctc ccttattatc cactgctaat 3901 gtggatgtat gttcaaacac cttttagtat tgatagctta catatggcca aaggaataca 3961 gtttatagca aaacargggt atgctgtagc taactttata aaagtgtaat ataacaatgt 4021 aaaaaattat atatctggga ggattttttg gttgcctaaa gtggctatag ttactgattt 4081 tttattatgt aagcaaaacc aataaaaatt taagtttttt taacaactac cttatttttc 4141 actgtacaga cactaattca ttaaatacta attgattgtt taaaagaaat ataaatgtga 4201 caagtggaca ttatttatgt taaatataca attatcaagc aagtatgaag ttattcaatt 4261 aaaatgccac atttctggtc tctggg (2) INFORMATION FOR SEQ ID NO:37: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1719 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:37: 1 gggctgcagg tttcgacccg cgctggcgag tcatgagcgc caagtttccc actggcgcgc 61 aaacttgagt tacttttgag cgtggatact ggcgaagagg ctgcgggcgg tattagcgtt 121 tgcagcgact tggctcgggc agctgacccc aaagtgtctg tcttccttcc tctgcttgtc 181 tctaggctct gaaactgcgg cggccaccgg acgcttctgg agcaggtagc agcatgcagc 241 cgcctccaag tctgtgcgga cgcgccctgg ttgcgctggt tcttgcctgc ggcctgtcgc 301 ggatctgggg agaggagaga ggcttcccgc ccgacagggc cactccgctt ttgcaaaccg 361 cagagataat gacgccaccc actaagacct tatggcccaa gggttccaac gccagtctgg 421 cgcggtcgtt ggcacctgcg gaggtgccta aaggagacag gacggcagga tctccgccac 481 gcaccatctc ccctcccccg tgccaaggac ccatcgagat caaggagact ttcaaataca 541 tcaacacggt tgtgtcctgc cttgtgttcg tgctggggat catcgggaac tccacacttc 601 tgagaattat ctacaagaac aagtgcatgc gaaacggtcc caatatcttg atcgccagct 661 tggctctggg agacctgctg cacatcgtca ttgacatccc tatcaatgtc tacaagctgc 721 tggcagagga ctggccattt ggagctgaga tgtgtaagct ggtgcctttc atacagaaag 781 cctccgtggg aatcactgtg ctgagtctat gtgctctgag tattgacaga tatcgagctg 841 ttgcttcttg gagtagaatt aaaggaattg gggttccaaa atggacagca gtagaaattg 901 ttttgatttg ggtggtctct gtggttctgg ctgtccctga agccataggt tttgatataa 961 ttacgatgga ctacaaagga agttatctgc gaatctgctt gcttcatccc gttcagaaga 1021 cagctttcat gcagttttac aagacagcaa aagattggtg gctgttcagt ttctatttct 1081 gcttgccatt ggccatcact gcattttttt atacactaat gacctgtgaa atgttgagaa 1141 agaaaagtgg catgcagatt gctttaaatg atcacctaaa gcagagacgg gaagtggcca 1201 aaaccgtctt ttgcctggtc cttgtctttg ccctctgctg gcttcccctt cacctcagca 1261 ggattctgaa gctcactctt tataatcaga atgatcccaa tagatgtgaa cttttgagct 1321 ttctgttggt attggactat attggtatca acatggcttc actgaattcc tgcattaacc 1381 caattgctct gtatttggtg agcaaaagat tcaaaaactg ctttaagtca tgcttatgct 1441 gctggtgcca gtcatttgaa gaaaaacagt ccttggagga aaagcagtcg tgcttaaagt 1501 tcaaagctaa tgatcacgga tatgacaact tccgttccag taataaatac agctcatctt 1561 gaaagaagaa ctattcactg tatttcattt tctttatatt ggaccgaagt cattaaaaca 1621 aaatgaaaca tttgccaaaa caaaacaaaa aactatgtat ttgcacagca cactattaaa 1681 atattaagtg taattatttt aaaaaaaaaa aaaaaaaaa (2) INFORMATION FOR SEQ ID NO:38: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 4156 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:38: t cccactatgt tggccaggat ggtcttgatt tcttgacctc gtgttctgcc cgcctctacc 61 tcccaaagtg ccgggattac aggcgtgact gctgtgcccg gccccagcat cacttttata 121 gctttctgtg cctcttcctc tgggccttgg tgtatgaagc cacttgcctt tctctgttgg 181 gaagcgagca gaatcagatt gctactcatg atgcagtccg ggcagggcat actgtcacct 241 ttggctgtgg acacagttgt caggataggg gagaagccct ttaggtccgt cttcttgaca 301 cagccctcct acctggttac gctggtgct tcgcttggtt tagacaacca agacacttga 361 gaattatgct gtcctcagaa tatctgatga aaagaacaga ttcacttttt ggacacaatg WO 00/09525 PCT/US99/17712 EPI-109 1193 421 cccattagcc atctttggca utgtttctga tcaaaagttc cccaza=ct ctctaggaaa 481 gtaaaczttt ttcagaataa arcctcaaat ggattactga gtagtcttta caccattccc 541 atcagcctaa tcagactgaa tggtcacgct cagtgcaaaa aaczgttttg ctgttaggat 601 gtttcagtgt ttcttgtctt tcctggaaca gttcagttgt ttaaatttag taattcaatc 661 ctgaccagtg taaacccact taattattgc agcctaaaga attcagcrac ttctactctt 721 cataaatgtg cccaagtaaa tatgtgtttt taatattcaa ccctggaaaa ttagtaattc 781 agatgataaa agctcatgtt ttggtgtctt tgtactcaga ttutgaacag gcatatttca 841 ctgatttaga cttagtatac ztgatgagaa tgctcaggtt gaagagatag ttctgtcagc 901 aatccaacat ctatagcaat gtggaaaaag taatcaactc atatttcacg aatttgatgt 961 atgttgtgat ttagagggca tgagataaag tttatatttg aactgtgtgg ggtaggggga 1021 agaagaggtt gcttaagcaa atqggggggt gattgaggaa caagatgtct ctaagatgag 1081 aagttatttt cttgcatcat agaagcactc tythyacccg ngagtgattg tgttaactat 1141 aaatcattta tatctgtaca ttaaagcaga ttccctcaat taggcaaatt tggttagcca 1201 agcccaagtt attgtttgta cttgaaagta ataaagctgc atttccttaa aaatatattc 1261 tgtagttaag actttgtctt gctttccgga attcctgttt ttcttttcct ctagagacct 1321 cggcttgcaa ctggatcaaa cgctgtcgaa aggatgtaaa taggcagagc aactgttacc 1381 aagaaggcca ccacccccac ccaaaggcag tgaggagtgt ggggcttcgt ctgggctccc 1441 ccgagtctca acagtaatca acagtcaggt gttgattgca acttttcaag gtcagccacc 1501 gggagtagcc tattccctct aggaaccttg gagggcatac cttgctggga ctcaacttgg 1561 ctgagaaatg cacaagatgc caaaggagga aggattatag ggggcgtgtg tgtgaccccc 1621 aagaccgatc ttccgctatc accctaatct ccggttcccc gctacccggg cgggggtgag 1681 tatgtgacat gtgcctaact ctcagcagca acttcggcag caggtgtcga tcctaactaa 1741 gcaggagctg cggctgccgg gtgtgccctc accaagccat gcgagccccg ggcgcgcttc 1801 tcgcccgcat gtcgcggcta ctgcttctgc tactgctcaa ggtgtctgcc tcttctgccc 1861 tcggggtcgc ccctgcgtcc agaaacgaaa cttgtctggg ggagagctgt gcacctacag 1921 tgatccagcg ccgcggcagg gacgcctggg gaccgggaaa ttctgcaaga gacgttctgc 1981 gagcccgagc acccagggag gagcaggggg cagcgtttct tgcgggaccc tcctgggacc 2041 tgccggcggc cccggaccgt gacccggctg caggcagagg ggcggaggcg tcgacagccg 2101 gacccccggg acctccaacc aggccacctg tcccctggag gtggaaaggt gctcggggtc 2161 aggagccttc tgaaactttg gggagaggga accccacggc cctccagctc ttccttcaga 2221 tctcagagga ggaagagaag ggtcccagag gcgctgtcat ttccgggcgt agccaggagc 2281 agagtgtgaa gacagtcccc ggagccagcg atctttttta ctgtccaagg agagccggga 2341 aactccaggg ttcccaccac aagcccctgt ccaagacggc caatggactg gcggggcacg 2401 aagggtggac aattgcactc ccgggccggg cgctggccca gaatggatcc ttgggtgaag 2461 gaatccatga tcctgggggt ccccgccggg gaaacagcac gaaccggcgt gtgagactga 2521 agaacccctt ctacccgctg acccaggagt cctatggagc ctacgcggtc atgtgtctgt 2581 ccgtggtgat cttcgggacc ggcatcattg gcaacctggc ggtgatgtgc atcgtgtgcc 2641 acaactacta catgcggagc atctccaact ccctcttggc caacctggtc ttctgggact 2701 ttctcatcat cttcttctgc cttccgctgg tcatcttcca cgagctgacc aagaagtggc 2761 tggtggagga cttctcctgc aagatcgtgc cctatataga ggtcgcttct ctgggagtca 2821 ccactttcac cttatgtgct ctgtgcatag accgcttccg tgctgccacc aacgtacaga 2881 tgtactacga aatgatcgaa aactgttcct caacaactgc caaacttgct gttatatggg 2941 tgggagctct attgttagca cttccagaag ttgttctccg ccagctgagc aaggaggatt 3001 tggggtttag tggccgagct ccggcagaaa ggtgcattat taagatCtct cctgatttac 3061 cagacaccat ctatgttcta gccctcacct acgacagtgc gagaCtgtgg tggtattttg 3121 gctgttactt ttgtttgccc acgcttttca ccatcacctg ctctctagtg actgcgagga 3181 aaatccgcaa agcagagaaa gcctgtaccc gagggaataa acggcagatt caactagaga 3241 gtcagatgaa ctgtacagta gtggcactga ccattttata tggattgggc attattcctg 3301 aaaatatctg caacattgtt actgcctaca tggctacagg ggtttcacag cagacaatgg 3361 acctccttaa tatcatcagc cagttccttt tgttctttaa gtcctgtgtc accccagtcc 3421 tccttttctg tctctgcaaa cccttcagtc gggccttcat ggagtgctgc tgctgttgct 3481 gtgaggaatg cattcagaag tcttcaacgg tgaccagtga tgacaatgac aacgagtaca 3541 ccacggaact cgaactctcg cctttcagtg ccatacgccg tgaaatgtcc acttttgctt 3601 ctgtcggaac tcattgctga aggacagtac ttggttgggt cagatttatt tgtttgattt 3661 tcatatcccg tgaaagtttt taattcatat ttttccttat agggaaaaat gcaaaaaaga 3721 aacaataaag aaagaaatat taactactgt agaactgatt ttacaaatta atatttgtgc 3781 tttgaaaaaa agtttctatt tagttattta agaagaatga gaaggccaat agttttagat 3841 tattttatct ggtatggtgc taatatttta tttgaaaaaa gttactgcaa cttaacttaa 3901. aattgctaac gttttttctt cttttaaaaa tacaattatt gtatattaat tatagcaatg 3961 tgattttgta ggttatttta tatttgagtt gtgattgaaa gtatgttgta tatggtattg 4021 tgagatgatt tgtacttgga agcattcaca aagtagcacc aaataaatta cactttattc 4081 tttaatgtca ttgtcaatct acttttaacc aatattcaat aaatcttcta attgccttaa 4141 aaaaaaaaaa aaaaaa (2) INFORMATION FOR SEQ ID NO:39: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1578 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single WO 00/09525 PCT/US99/17712 EPI-109 1194 (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:39: 1 gggctgcagg tttcgacccg cgctggcgag tcatgagcgc caagtttccc aczggcgcgc 61 aaacttgagt tacttttgag cgtggatact ggcgaagagg ctgcgggcgg tattagcgtt 121 tgcagcgact tggctcgggc agctgacccc aaagtgtctg tcttccttcc tctgcttgtc 181 tctaggctct gaaactgcgg cggccaccgg acgcttctgg agcaggtagc agcatgcagc 241 cgcctccaag tctgtgcgga cgcgccctgg ttgcgctggt tcttgcctgc ggcctgtcgc 301 ggatctgggg agaggagaga ggcttcccgc ccgacagggc cactccgctt ttgcaaaccg 361 cagagataat gacgccaccc actaagacct tatggcccaa gggttccaac gccagtctgg 421 cgcggtcgtt ggcacctgcg gaggtgccta aaggagacag gacggcagga tctccgccac 481 gcaccatctc ccctcccccg tgccaaggac ccatcgagat caaggagact ttcaaataca 541 tcaacacggt tgtgtcctgc cttgtgttcg tgctggggat catcgggaac tccacacttc 601 tgagaattat ctacaagaac aagtgcatgc gaaacggtcc caatatcttg atcgccagct 661 tggctctggg agacctgctg cacatcgtca ttgacatccc tatcaatgtc tacaagctgc 721 tggcagagga ctggccattt ggagctgaga tgtgtaagct ggtgcctttc atacagaaag 781 cctccgtggg aatcactgtg ctgagtctat gtgctctgag tattgacaga tatcgagctg 841 ttgcttcttg gagtagaatt aaaggaattg gggttccaaa atggacagca gtagaaattg 901 ttttgatttg ggtggtctct gtggttctgg ctgtccctga agccataggt tttgatataa 961 ttacgatgga ctacaaagga agttatctgc gaatctgctt gcttcatccc gttcagaaga 1021 cagctttcat gcagttttac aagacagcaa aagattggtg gctgttcagt ttctatttct 1081 gcttgccatt ggccatcact gcattttttt atacactaat gacctgtgaa atgttgagaa 1141 agaaaagtgg catgcagatt gctttaaatg atcacctaaa gcagagacgg gaagtggcca 1201 aaaccgtctt ttgcctggtc cttgtctttg ccctctgctg gcttcccctt cacctcagca 1261 ggattctgaa gctcactctt tataatcaga atgatcccaa tagatgtgaa cttttgagct 1321 ttctgttggt attggactat attggtatca acatggcttc actgaattcc tgcattaacc 1381 caattgctct gtatttggtg agcaaaagat tcaaaaactg ctttaaggct gggccacatg 1441 ttggaaataa gctagtaatg ttgttttctg tcaatattga atgtgatggt acagtaaacc 1501 aaaacccaac aatgtggcca gaaagaaaga gcaataataa ttaattcaca caccatatgg 1561 attctattta taaatcac (2) INFORMATION FOR SEQ ID NO:40: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 13611 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQtJENCE DESCRIPTION: SEQ ID NO:40: 1 aggagtttcg acccgcgctg gcgagtcatg agcgccaagt ttcccactgg cgcgcaaact 61 tgagttactt ttgagcgtgg atactggcga agaggctgcg ggcggtatta gcgtttgcag 121 cgacttggct cgggcagctg acccaagtgt cctgtcttcc ttcctctgct tgtctctagg 181 ctctgaaact gcggagcggc caccggacgc cttctggagc aggtagcagc atgcagccgc 241 ctccaagtct gtgcggaccg gccctggttg cgctggttct tgcctgcggc ctgtcgcgga 301 tctggggaga ggagagaggc ttcccgcctg acagggccac tccgcttttg caaaccgcag 361 agataatgac gccacccact aagaccttat ggcccaaggg ttccaacgcc agtctggcgc 421 ggtcgttggc acctgcggag gtgcctaaag gagacaggac ggcaggatct ccgccacgca 481 ccatctcccc tcccccgtgc caaggaccca tcgagatcaa ggagactttc aaatacatca 541 acacggttgt gtcctgcctt gtgttcgtgc tggggatcat cgggaactcc acacttctga 601 gaattatcta caagaacaag tgcatgcgaa acggtcccaa tatcttgatc gccagcttgg 661 ctctgggaga cctgctgcac atcgtcattg acatccctat caatgtctac aagctgctgg 721 cagaggactg gccatttgga gctgagatgt gtaagctggt gcctttcata cagaaagcct 781 ccgtgggaat cactgtgctg agtctatgtg ctctgagtat tgacagatat cgagctgttg 841 cttcttggag tagaattaaa ggaattgggg ttccaaaatg gacagcagta gaaattgttt 901 tgatttgggt ggtctctgtg gttctggctg tccctgaagc cataggtttt gatataatta 961 cgatggacta caaaggaagt tatctgcgaa tctgcttgct tcatcccgtt cagaagacag 1021 ctttcatgca gttttacaag acagcaaaag attggtggct attcagtttc tatttctgct 1081 tgccattggc catcactgca tttttttata cactaatgac ctgtgaaatg ttgagaaaga 1141 aaagtggcat gcagattgct ttaaatgatc acctaaagca gagacgggaa gtggccaaaa 1201 ccgtcttttg cctggtcctt gtctttgccc tctgctggct tccccttcac ctcagcagga 1261 ttctgaagct cactctttat aatcagaatg atcccaatag atgtgaactt ttgagctttc 1321 tgttggtatt ggactatatt ggtatcaaca tggcttcact gaattcctgc attaacccaa 1381 ttgctctgta tttggtgagc aaaagattca aaaactgctt taagtcatgc ttatgctgct 1441 ggtgccagtc atttgaagaa aaacagtcct tggaggaaaa gcagtcgtgc ttaaagttca 1501 aagctaatga tcacggatat gacaacttcc gttccagtaa taaatacagc tcatcttgaa 1561 agaagaacta ttcactgtat ttcattttct ttatattgga ccgaagtcat taaaacaaaa 1621 tgaaacattt gccaaaacaa aacaaaaaac tatgtatttg cacagcacac tattaaaata 1681 ttaagtgtaa ttattttaac actcacagct acatatgaca ttttatcagc tgtttacggc 1741 atggaaagaa aatcagtggg aattaagaaa gcctcgtcgt gaaagcactt aattttttac 1801 agttagcact tcaacatagc tcttaacaac ttccaggata ttcacacaac acttaggctt 1861 aaaaatgagc tc WO 00/09525 PCTIUS99/17712 EPI-109 1195 gagacattcc ggtgggggac tc:agccagc ccgagcaacg tggatcctga gagcactccc 61 aggraggcat ttgccccggt gggacgcctt gccagagcag tgtgtggcag gcccccgtgg 121 aggatcaaca cagtggctga acactgggaa ggaactggta cttggagtct ggacatctga 181 aacttggctc tgaaactgcg cagcggccac cggacgcctt ctggagcagg tagcagcatg 241 cagccgcctc caagtctgtg cggacgcgcc ctggttgcgc tggttcttgc ctgcggcctg 301 tcgcggatct ggggagagga gagaggcttc ccgcctgaca gggccactcc gcttttgcaa 361 accgcagaga taatgacgcc acccactaag accttatggc ccaagggttc caacgccagt 421 ctggcgcggt cgttggcacc tgcggaggtg cctaaaggag acaggacggc aggatctccg 481 ccacgcacca tctcccctcc cccgtgccaa ggacccatcg agatcaagga gactttcaaa 541 tacatcaaca cagttgtgtc ctgccttgtg ttcgtgctgg ggatcatcgg gaactccaca 601 cttctgagaa ttatctacaa gaacaagtgc atgcgaaacg gtcccaatat cttgatcgcc 661 agcttggctc tgggagacct gctgcacatc gtcattgaca tccctatcaa tgtctacaag 721 ctgctggcag aggactggcc atttggagct gagatgtgta agctggtgcc tttcatacag 781 aaagcctccg tgggaatcac tgtgctgagt ctatgtgctc tgagtattga cagatatcga 841 gctgttgctt cttggagtag aattaaagqa attggggttc caaaatggac agcagtagaa 901 attgttttga tttgggtggt ctctgtggtt ctggctgtcc ctgaagccat aggttttgat 961 ataattacga tggactacaa aggaagttat ctgcgaatct gcttgcttca tcccgttcag 1021 aagacagctt tcatgcagtt ttacaagaca gcaaaagatt ggtggctgtt cagtttctat 1081 ttctgcttgc cattggccat cactgcattt ttttatacac taatgacctg tgaaatgttg 1141 agaaagaaaa gtggcatgca gattgcttta aatgatcacc taaagcagag acgggaagtg 1201 gccaaaaccg tcttttgcct ggtccttgtc tttgccctct gctggcttcc ccttcacctc 1261 agcaggattc tgaagctcac tctttataat cagaatgatc ccaatagatg tgaacttttg 1321 agctttctgt tggtattgga ctatattggt atcaacatgg cttcactgaa ttcctgcatt 1381 aacccaattg ctctgtattt ggtgagcaaa agattcaaaa actgctttaa gtcatgctta 1441 tgctgctggt gccagtcatt tgaagaaaaa cagtccttgg aggaaaagca gtcgtgctta 1501 aagttcaaag ctaatgatca cggatatgac aacttccgtt ccagtaataa atacagctca 1561 tcttgaaaga agaactattc actgtatttc attttcttta tattggaccg aagtcattaa 1621 aacaaaatga aacatttgcc aaaacaaaac aaaaaactat gtatttgcac agcacactat 1681 taaaatatta agtgtaatta ttttaacact cacagctaca tatgacattt tatgagctgt 1741 ttacggcatg gaaagaaaat cagtgggaat taagaaagcc tcgtcgtgaa agcacttaat 1801 tttttacagt tagcacttca acatagctct taacaacttc caggatattc acacaacact 1861 taggcttaaa aatgagctca ctcagaattt ctattctttc taaaaagaga tttattttta 1921 aatcaatggg actctgatat aaaggaagaa taagtcactg taaaacagaa cttttaaatg 1981 aagcttaaat tactcaattt aaaattttaa aatcctttaa aacaactttt caattaatat 2041 tatcacacta ttatcagatt gtaattagat gcaaatgaga gagcagttta gttgttgcat 2101 ttttcggaca ctggaaacat ttaaatgatc aggagggagt aacagaaaga gcaaggctgt 2161 ttttgaaaat cattacactt tcactagaag cccaaacctc agcattctgc aatatgtaac 2221 caacatgtca caaacaagca gcatgtaaca gactggcaca tgtgccagct gaatttaaaa 2281 tataatactt ttaaaaagaa aattattaca tcctttacat tcagttaaga tcaaacctca 2341 caaagagaaa tagaatgttt gaaaggctat cccaaaagac ttttttgaat ctgtcattca 2401 cataccctgt gaagacaata ctatctacaa ttttttcagg attattaaaa tcttcttttt 2461 tcactatcgt agcttaaact ctgtttggtt ttgtcatctg taaatactta cctacataca 2521 ctgcatgtag atgattaaat gagggcaggc cctgtgctca tagctttacg atggagagat 2581 gccagtgacc tcataataaa gactgtgaac tgcctggtgc agtgtccaca tgacaaaggg 2641 gcaggtagca ccctctctca cccatgctgt ggttaaaatg gtttctagca tatgtataat 2701 gctatagtta aaatactatt tttcaaaatc atacagatta gtacatttaa cagctacctg 2761 taaagcttat tactaatttt tgtattattt ttgtaaatag ccaatagaaa agtttgcttg 2821 acatggtgct tttctttcat ctagaggcaa aactgctttt tgagaccgta agaacctctt 2881 agctttgtgc gttcctgcct aatttttata tcttctaagc aaagtgcctt aggatagctt 2941 gggatgagat gtgtgtgaaa gtatgtacaa gagaaaacgg aagagagagg aaatgaggtg 3001 gggttggagg aaacccatgg ggacagattc ccattcttag cctaacgttc gtcattgcct 3061 cgtcacatca atgcaaaagg tcctgatttt gttccagcaa aacacagtgc aatgttctca 3121 gagtgacttt cgaaataaat tgggcccaag agctttaact cggtcttaaa atatgcccaa 3181 atttttactt tgtttttctt ttaataggct gggccacatg ttggaaataa gctagtaatg 3241 ttgttttctg tcaatattga atgtgatggt acagtaaacc aaaacccaac aatgtggcca 3301 gaaagaaaga gcaataataa ttaattcaca caccatatgg attctattta taaatcaccc 3361 acaaacttgt tctttaattt catcccaatc actttttcag aggcctgtta tcatagaagt 3421 cattttagac tctcaatttt aaattaattt tgaatcacta atattttcac agtttattaa 3481 tatatttaat ttctatttaa attttagatt atttttatta ccatgtactg aatttttaca 3541 tcctgatacc ctttccttct ccatgtcagt atcatgttct ctaattatct tgccaaattt 3601 tgaaactaca cacaaaaagc atacttgcat tatttataat aaaattgcat tcagtggctt 3661 tttaaaaaaa atgtttgatt caaaacttta acatactgat aagtaagaaa caattataat 3721 ttctttacat actcaaaacc aagatagaaa aaggtgctat cgttcaactt caaaacatgt 3781 ttcctagtat taaggacttt aatatagcaa cagacaaaat tattgttaac atggatgtta 3841 cagctcaaaa gatttataaa agattttaac ctattttctc ccttattatc cactgctaat 3901 gtggatgtat gttcaaacac cttttagtat tgatagctta catatggcca aaggaataca 3961 gtttatagca aaacatgggt atgctgtagc taactttata aaagtgtaat ataacaatgt 4021 aaaaaattat atatctggga ggattttttg gttgcctaaa gtggctatag ttactgattt WO 00/09525 PCTIUS99/17712 EPI-109 1196 4081 tttattatgt aagcaaaacc aataaaaatt taagtttttt taacaactac cttattttte 4141 actgtacaga cactaattca ttaaatacta a~tgattgtt taaaagaaat ataaatgtga 4201 caagtggaca ttatttatgt taaatataca attatcaagc aagtatgaag ttattcaatt 4261 aaaatgccac atttctggtc tctggg 1 gggctgcagg tttcgacccg cgctggcgag tcatgagcgc caagtttccc actggcgcgc 61 aaacttgagt tacttttgag cgtggatact ggcgaagagg ctgcgggcgg tattagcgtt 121 tgcagcgact tggctcgggc agctgacccc aaagtgtctg tcttccttcc tctgcttgtc 181 tctaggctct gaaactgcgg cggccaccgg acgcttctgg agcaggtagc agcatgcagc 241 cgcctccaag tctgtgcgga cgcgccctgg ttgcgctggt tcttgcctgc ggcctgtcgc 301 ggatctgggg agaggagaga ggcttcccgc ccgacagggc cactccgctt ttgcaaaccg 361 cagagataat gacgccaccc actaagacct tatggcccaa gggttccaac gccagtctgg 421 cgcggtcgtt ggcacctgcg gaggtgccta aaggagacag gacggcagga tctccgccac 481 gcaccatctc ccctcccccg tgccaaggac ccatcgagat caaggagact ttcaaataca 541 tcaacacggt tgtgtcctgc cttgtgttcg tgctggggat catcgggaac tccacacttc 601 tgagaattat ctacaagaac aagtgcatgc gaaacggtcc caatatcttg atcgccagct 661 tggctctggg agacctgctg cacatcgtca ttgacatccc tatcaatgtc tacaagctgc 721 tggcagagga ctggccattt ggagctgaga tgtgtaagct ggtgcctttc atacagaaag 781 cctccgtggg aatcactgtg ctgagtctat gtgctctgag tattgacaga tatcgagctg 841 ttgcttcttg gagtagaatt aaaggaattg gggttccaaa atggacagca gtagaaattg 901 ttttgatttg ggtggtctct gtggttctgg ctgtccctga agccataggt tttgatataa 961 ttacgatgga ctacaaagga agttatctgc gaatctgctt gcttcatccc gttcagaaga 1021 cagctttcat gcagttttac aagacagcaa aagattggtg gctgttcagt ttctatttct 1081 gcttgccatt ggccatcact gcattttttt atacactaat gacctgtgaa atgttgagaa 1141 agaaaagtgg catgcagatt gctttaaatg atcacctaaa gcagagacgg gaagtggcca 1201 aaaccgtctt ttgcctggtc cttgtctttg ccctctgctg gcttcccctt cacctcagca 1261 ggattctgaa gctcactctt tataatcaga atgatcccaa tagatgtgaa cttttgagct 1321 ttctgttggt attggactat attggtatca acatggcttc actgaattcc tgcattaacc 1381 caattgctct gtatttggtg agcaaaagat tcaaaaactg ctttaagtca tgcttatgct 1441 gctggtgcca gtcatttgaa gaaaaacagt ccttggagga aaagcagtcg tgcttaaagt 1501 tcaaagctaa tgatcacgga tatgacaact tccgttccag taataaatac agctcatctt 1561 gaaagaagaa ctattcactg tatttcattt tctttatatt ggaccgaagt cattaaaaca 1621 aaatgaaaca tttgccaaaa caaaacaaaa aactatgtat ttgcacagca cactattaaa 1681 atattaagtg taattatttt aaaaaaaaaa aaaaaaaaa 1 cccactatgt tggccaggat ggtcttgatt tcttgacctc gtgttctgcc cgcctctacc 61 tcccaaagtg ccgggattac aggcgtgact gctgtgcccg gccccagcat cacttttata 121 gctttctgtg cctcttcctc tgggccttgg tgtatgaagc cacttgcctt tctctgttgg 181 gaagcgagca gaatcagatt gctactcatg atgcagtccg ggcagggcat actgtcacct 241 ttggctgtgg acacagttgt caggataggg gagaagccct ttaggtccgt cttcttgaca 301 cagccctcct acctggttac gctggtgctt tcgcttggtt tagacaacca agacacttga 361 gaattatgct gtcctcagaa tgtctgatga aaagaacaga ttcacttttt ggacacaatg 421 cccattagcc atctttggca gtgtttctga tcaaaggttc cccatgcctg ctctaggaaa 481 gtaaactttt ttcagaataa atcctcaaat ggattactga gtagtctttg caccattccc 541 atcagcctaa tcagactgaa tggtcacgct cagtgcaaaa agctgttttg ctgttaggat 601 gtttcagtgt ttcttgtctt tcctggaaca gttcagttgt ttaaatttag taattcaatc 661 ctgaccagtg taaacccact taattattgc agcctaaaga attcagctac ttctactctt 721 cataaatgtg cccaagtaaa tatgtgtttt taatattcaa ccctggaaaa ttagtaattc 781 agatgataaa agctcatgtt ttggtgtctt tgtactcaga ttgtgaacag gcatatttca 841 ctgatttaga cttagtatac ttgatgagaa tgctcaggtt gaagagatag ttctgtcagc 901 aatccaacat ctatagcaat gtggaaaaag taatcaactc atatttcacg aatttgatgt 961 atgttgtgat ttagagggca tgagataaag tttatatttg aactgtgtgg ggtaggggga 1021 agaagaggtt gcttaagcaa atgggggggt gattgaggaa caagatgtct ctaagatgag 1081 aagttatttt cttgcatcat agaagcactc tythyacccg ngagtgattg tgttaactat 1141 aaatcattta tatctgtaca ttaaagcaga ttccctcaat taggcaaatt tggttagcca 1201 agcccaagtt attgtttgta cttgaaagta ataaagctgc atttccttaa aaatatattc 1261 tgtagttaag actttgtctt gctttccgga attcctgttt ttcttttcct ctagagacct 1321 cggcttgcaa ctggatcaaa cgctgtcgaa aggatgtaaa taggcagagc aactgttacc 1381 aagaaggcca ccacccccac ccaaaggcag tgaggagtgt ggggcttcgt ctgggctccc 1441 ccgagtctca acagtaatca acagtcaggt gttgattgca acttttcaag gtcagccacc 1501 gggagtagcc tattccctct aggaaccttg gagggcatac cttgctggga ctcaacttgg 1561 ctgagaaatg cacaagatgc caaaggagga aggattatag ggggcgtgtg tgtgaccccc 1621 aagaccgatc ttccgctatc accctaatct ccggttcccc gctacccggg cgggggtgag 1681 tatgtgacat gtgcctaact ctcagcagca acttcggcag caggtgtcga tcctaactaa 1741 gcaggagctg cggctgccgg gtgtgccctc accaagccat gcgagccccg ggcgcgcttc 1801 tcgcccgcat gtcgcggcta ctgcttctgc tactgctcaa ggtgtctgcc tcttctgccc 1861 tcggggtcgc ccctgcgtcc agaaacgaaa cttgtctggg ggagagctgt gcacctacag 1921 tgatccagcg ccgcggcagg gacgcctggg gaccgggaaa ttctgcaaga gacgttctgc 1981 gagcccgagc acccagggag gagcaggggg cagcgtttct tgcgggaccc tcctgggacc 2041 tgccggcggc cccggaccgt gacccggctg caggcagagg ggcggaggcg tcgacagccg WO 00/09525 PCT/US99/17712 EPI-109 1197 2101 gacccccggg accccaacc aggccacctg tccccragag gtggaaaggt gctcggggtc 2161 aggagccttc tgaaactttg gggagaggga accccacggc cctccagctc ttccttcaga 2221 tctcagagga ggaagagaag ggtcccagag gCgctgtCat ttCCgggCgt agccaggagc 2281 agagtgtgaa gacagtcccc ggagccagcg atctttttta ctgtccaagg agagccggga 2341 aactccaggg ttcccaccac aagcccctgt ccaagacggc caatggactg gcggggcacg 2401 aagggtggac aattgcacrc ccgggccggg cgctggccca gaatggatcc ttgggtgaag 2461 gaatccatga tcctgggggt ccccgccggg gaaacaqcac gaaccggcgt gtgagactga 2521 agaacccctt ctacccgctg acccaggagt cctatggagc ctacgcggtc atgtgtctgt 2581 ccgiggtgat cttcgggacc ggcatcattg gcaacctggc ggtgatgtgc atcgtgtgcc 2641 acaactacta catgcggagc atctccaact ccctcttggc caacctggtc ttctgggact 2701 ttctcatcat cttcttctgc cttccgctgg tcatcttcca cgagczgacc aagaagtggc 2761 tggtggagga cttctcctgc aagatcgtgc cctatataga ggtcgcttCt ctgggagtca 2821 ccactttcac cttatgtgct ctgtgcatag accgcttccg tgctgccacc aacgtacaga 2881 tgtactacga aatgatcgaa aactgttcct caacaactgc caaacttgct gttatatggg 2941 tgggagctct attgttagca cctccagaag ttgttctccg ccagctgagc aaggaggatt 3001 tggggtttag tggccgagct ccggcagaaa ggtgcattat taagatctct cctgatttac 3061 cagacaccat ctatgttcta gccctcacct acgacagtgc gagactgtgg tggtattttg 3121 gctgttactt ttgtttgccc acgcttttca ccatcacctg ctctctagtg actgcgagga 3181 aaatccgcaa agcagagaaa gcctgtaccc gagggaataa acggcagatt caactagaga 3241 gtcagatgaa ctgtacagta gtggcactga ccattttata tggattgggc attattcctg 3301 aaaatatctg caacattgtt actgcctaca tggctacagg ggtttcacag cagacaatgg 3361 acctccttaa tatcatcagc cagttccttt tgttctttaa gtcctgtgtc accccagtcc 3421 tccttttctg tctctgcaaa cccttcagtc gggccttcat ggagtgctgc tgctgttgct 3481 gtgaggaatg cattcagaag tcttcaacgg tgaccagtga tgacaatgac aacgagtaca 3541 ccacggaact cgaactctcg cctttcagtg ccatacgccg tgaaatgtcc acttttgctt 3601 ctgtcggaac tcattgctga aggacagtac ttggttgggt cagatttatt tgtttgattt 3661 tcatatcccg tgaaagtttt taattcatat ttttccttat agggaaaaat gcaaaaaaga 3721 aacaataaag aaagaaatat taactactgt agaactgatt ttacaaatta atatttgtgc 3781 tttgaaaaaa agtttctatt tagttattta agaagaatga gaaggccaat agttttagat 3841 tattttatct ggtatggtgc taatatttta tttgaaaaaa gttactgcaa cttaacttaa 3901 aattgctaac gttttttctt cttttaaaaa tacaattatt gtatattaat tatagcaatg 3961 tgattttgta ggttatttta tatttgagtt gtgattgaaa gtatgttgta tatggtattg 4021 tgagatgatt tgtacttgga agcattcaca aagtagcacc aaataaatta cactttattc 4081 tttaatgtca ttgtcaatct acttttaacc aatattcaat aaatcttcta attgccttaa 4141 aaaaaaaaaa aaaaaa 1 gggctgcagg tttcgacccg cgctggcgag tcatgagcgc caagtttccc actggcgcgc 61 aaacttgagt tacttttgag cgtggatact ggcgaagagg ctgCgggcgg tattagcgtt 121 tgcagcgact tggctcgggc agctgacccc aaagtgtctg tcttccttcc tctgcttgtc 181 tctaggctct gaaactgcgg cggccaccgg acgcttctgg agcaggtagc agcatgcagc 241 cgcctccaag tctgtgcgga cgcccctgg ttgcgctggt tcttgcctgc ggcctgtcgc 301 ggatctgggg agaggagaga ggcttcccgc ccgacagggc cactccgctt ttgcaaaccg 361 cagagataat gacgccaccc actaagacct tatggcccaa gggttccaac gccagtctgg 421 cgcggtcgtt ggcacctgcg gaggtgccta aaggagacag gacggcagga tctccgccac 481 gcaccatctc ccctcccccg tgccaaggac ccatcgagat caaggagact ttcaaataca 541 tcaacacggt tgtgtcctgc cttgtgttcg tgctggggat catcgggaac tccacacttc 601 tgagaattat ctacaagaac aagtgcatgc gaaacggtcc caatatcttg atcgccagct 661 tggctctggg agacctgctg cacatcgtca ttgacatccc tatcaatgtc tacaagctgc 721 tggcagagga ctggccattt ggagctgaga tgtgtaagct ggtgcctttC atacagaaag 781 cctccgtggg aatcactgtg ctgagtctat gtgctctgag tattgacaga tatcgagctg 841 ttgcttcttg gagtagaatt aaaggaattg gggttccaaa atggacagca gtagaaattg 901 ttttgatttg ggtggtctct gtggttctgg ctgtccctga agccataggt tttgatataa 961 ttacgatgga ctacaaagga agttatctgc gaatctgctt gcttcatccc gttcagaaga 1021 cagctttcat gcagttttac aagacagcaa aagattggtg gctgttcagt ttctatttct 1081 gcttgccatt ggccatcact gcattttttt atacactaat gacctgtgaa atgttgagaa 1141 agaaaagtgg catgcagatt gctttaaatg atcacctaaa gcagagacgg gaagtggcca 1201 aaaccgtctt ttgcctggtc cttgtctttg ccctctgctg gcttcccctt cacctcagca 1261 ggattctgaa gctcactctt tataatcaga atgatcccaa tagatgtgaa cttttgagct 1321 ttctgttggt attggactat attggtatca acatggcttc actgaattcc tgcattaac 1381 caattgctct gtatttggtg agcaaaagat tcaaaaactg ctttaaggct gggccacatg 1441 ttggaaataa gctagtaatg ttgttttctg tcaatattga atgtgatggt acagtaaacc 1501 aaaacccaac aatgtggcca gaaagaaaga gcaataataa ttaattcaca caccatatgg 1561 attctattta taaatcac (2) INFORMATION FOR SEQ ID NO:41: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 12461 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear WO 00/09525 PCT/US99/17712 EPI-109 1198 (xi)SEQUENCE DESCRIPTION: SEQ ID NO:41: 1 gatatcctat taatacaaag atacagaaag aaatacataa aaaatagttt tatcaaatac 61 tttccagcat t-caagtgtag cctcaaaagc aagaataggc caggagtggt ggctcacgct 121 gtaatccaca gcactgtggg aggccaaggt aagaggattg cttgaggcca ggatttcaag 181 accagcctag gcaacatagt gagatcccta tctctacgaa aaaattttaa aacttagctg 241 ggcatggtgc ttaaqcctgt tgtcccagct actcaggagg tgaagtagga gtgtcacttg 301 agcccaggag gttgaggctg cagtgagcta taactgcacc actgcactcc agccttggag 361 acagagtgag accctgtccc caaaaaaatt aaaattgaga aaaaaaaaaa ggcaagaaca 421 gccacagcaa actttctatt ggggaaaaaa aaaaatcctc ctctttacat ctctcccttc 481 cttcccttcc ctttctgaga gtgactgtgg ccaaaaggag cattttcccc ctgcagtcct 541 ctgaggggtg gggtggggct atgaagccat ccttcatatt cactcctttg tccagctctt 601 ttcacctcta gttcttctcc ccgcatctct gtctagcagt gccttaagtg gaggaggggt 661 gggggcatca agcttgtaaa actggtttgt tggggttctc cttctcccct catttcttga 721 ttcttgggaa aatgtcttgc tgggaggctg cctggcgagt gccctagctg ccttctgtgg 781 gcttgaatgg ggcttccctc tgcccctaca ggaggaaaag ggagctgctg ccagagggag 841 aaatggagag atggacagag aaggcaggtg ccacccctcg cccctgacac acaaagaaaa 901 agacacggaa attctctctc tctcttctct tctcctatct ctctctctct ccctctctct 961 ctctctctct ctctctctca cacacacaca cacacacaca cacacacaca caggcgcgcg 1021 ccgcgcgcgc aggcacacgt cttgcaaatt caggattcaa agagacaggg gcaccattat 1081 atttggcacg gtggggcctt ccaggtctga aatcctgcat tcttccttac tatttacttt 1141 ccccgagctc gagaagggcc aggtgtgggc ggatggctgg ccacgttttg tgtttccaat 1201 tcatattcac gggatgacac agacgggqcg tggtgagtgc tgttggaggc gcttgggcag 1261 tttcactcg ccccacttct ccacctgaag gctgggcgtt gctggaacct gcaggggcag 1321 cctcagcaag gtggggtggc gtggagtggg gtgggagaag ggactccagc tgaagtagaa 1381 cccaggctgg acctgagaat attggggagg gcatgggcgg tggtttccgg gtaggggcct 1441 tgaggacatg ttggtcctga ctgttgtcag tgtttggtca aagttgccaa aaggttaaaa 1501 aaaaaaaagt agggggagtc cctgccaaga catatttccc aggccacctt tcttccgcgg 1561 gagtgttggg ggggaggcgc tgcttggaac ctgtgaatgt gacatcagct ctcctctcct 1621 ctcccaaggt cggctttgga gagggaggtc agggcaccct tgcctggcac aggcacgctg 1681 gcttccggct cagtgccgcc tgctctccgg gagctgtgcg ctccctgggc cccggggcta 1741 ggctgaggta agcgcacagc ggaggccagg cgcgccggca gaggcctggg ggatagggtg 1801 gaggcatctc tgggtgtggg tgtgggtgtg ggtgtgggag ggagagttct tgcctctctc 1861 tctcccatct ccaactcttg cttcagtggc tcttttagag gatgcatgtc attatggacc 1921 tgtcgctgcc actgtccctg ttcccccagc tgtgacttcg agggaggtct ggggatctga 1981 gtctgtccaa acccacggct ttgctgttgg gataaaaact gtccttttga ttttagaagg 2041 aggagggaaa aaaggtttcc cagcatgtgt gttgtgccag tcttggaaat tcatccgtgc 2101 ttgaattcca ccctccatcc ccagaaaaac tggagtaaaa caaaaagagg agatggacaa 2161 agtgtgtatt tgatggcatc ccctgggaag agactctaaa tttatcccat aggtcttact 2221 gggccactgt gagcgctttg gtggagaaca aacaaaaatt ctgggtgctc agttgtctaa 2281 cctgaaaaat gggactagcg gaaaaagcca atgtgttcca tgcacctttt gctttcttta 2341 ttaaggcatg atgtcacctg tacagtaact gccctgtgtg tacttcaggg ggggatttca 2401 aggttagata gacaggaaat tgttttgaaa atgtaaacac attattaaat gtgaagtatt 2461 atctgattcc ttgttcgaat ggcatttcct tctcagcacc accttccttg catattcact 2521 taaccttgta caagaacacc tttttgccct aaatgaagac acccccccaa aaaaaagagt 2581 cccagaaaac atgtccctgc ttgtgcggga ataaatagaa tattctgagg tgcattcctc 2641 cttcctatgt taggcaacat tccttgaccc tcctcggccc ccaagccagg ttgcgttttt 2701 ttctgccatt tagaagggtt ttcctttttg tcctagtaaa acatcagccc ctgtagctct 2761 tcatctcccc ctggtgttct tctcccgcca tgtcttaaga ttggtggcac cgaccaatct 2821 taagatttaa gttctgtgtg aaaaacacct ttgcttttca atcagtttat cagcctcctc 2881 cgcaggggaa tgtggacaca caaaagaact tatcggggct tctcatcagt gatagggaaa 2941 agactggcat gtgcctaaac gagctctgat gttattttta agctcccttt cttgccaatc 3001 cctcacggat ctttctccga tagatgcaaa gaacttcagc aaaaaagacc cgcaggaagg 3061 ggcttgaaga gaaaagtacg ttgatctgcc aaaatagtct gacccccagt agtgggcagt 3121 gacgagggag agcattccct tgtttgactg agactagaat cggagagaca taaaaggaaa 3181 atgaagcgag caacaattaa aaaaaattcc ccgcacacaa caatacaatc tatttaaact 3241 gtggctcata cttttcatac caatggtatg actttttttc tggagtcccc tcttctgatt 3301 cttgaactcc ggggctggca gcttgcaaag gggaagcgga ctccagcact gcacgggcag 3361 gtttagcaaa ggtctctaat gggtattttc tttttcttag ccctgccccc gaattgtcag 3421 acggcgggcg tctgcttctg aagttagcag tgatttcctt tcgggcctgg cttatctccg 3481 gctgcacgtt gcctgttggt gactaataac acaataacat tgtctggggc tggaataaag 3541 tcggagctgt ttacccccac tctaataggg gttcaatata aaaagccggc agagagctgt 3601 ccaagtcaga cgcgcctctg catctgcgcc aggcgaacgg gtcctgcgcc tcctgcagtc 3661 ccagctctcc accgccgcgt gcgcctgcag acgctccgct cgctgccttc tctcctggca 3721 ggcgctgcct tttctccccg ttaaagggca cttgggctga aggatcgctt tgagatctga 3781 ggaacccgca gcgctttgag ggacctgaag ctgtttttct tcgttttcct ttgggttcag 3841 tttgaacggg aggtttttga tccctttttt tcagaatgga ttatttgctc atgattttct 3901 ctctgctgtt tgtggcttgc caaggagctc cagaaacagg taggcacgct cgttgacttg 3961 taagtctcgg aactacaagt tagtgtgttc ttatccacct tcatgctttt cttgcttcta WO 00/09525 PCT/US99/17712 EPI-109 1199 4021 tttttccccg zttttttat gactgcagct zagagagcaa gtgtctgaga attattgctg 4081 aaacgtactt :aagtcttct agtgtaaaat ataaaattcc tctactgaat acaattaggt 4141 gcaattgact ataacatqac attaaaataa cttatcgttt tattattatt attccattat 4201 gtgtttcctt agcttttaaa aaatgagaag agtatggaca tatacaattt agtcaaatgt 4261 atgtttgtaa tatatgtgtt tatacaggta cacaggccat ataggaactt aaatcttatt 4321 taaacactat tttaatagtg tgttaacgtg taaaatattt aagcattcca gcttgaagcc 4381 aaggaattgt atccagtcgt tcaagcaatg tatgttcagt aaaatcacct gcagagcaaa 4441 agtctgttga ctaactaccg cctcccccgc ccccccacca ccccccgcag gcggtttctg 4501 ggtgaagcag atgttttctt taaaatttgt catcattgac tttaggtttc ttttggcagg 4561 tttttggcac ccaaaacagt gtgagctctc ttttcagctt tattcacctg tgctgggagg 4621 ggagctagga taattcttgg ctgccgaagg atttaggcag tgcgtgtgca tctgcccggg 4681 tcccccccgt ttttagggtc agtgcacttt ttttgtcttt tcgtgaccct gactaaagag 4741 aaaggatgtc aagggaatga aaatcctgga atgtgtctga tcatttgaaa tgtacaaaat 4801 tgggcagata agctgcatgg ctaaattgtt aggaggaaga ggcaaggcag tagtggagaa 4861 gggggaggca gtggatccca cacaagcctg atgcccaggg attcqgaatt caaaatcccc 4921 ccagcctacc ttcagtcccc tgacctgctt ctcagcccca ccttaggtca ctggtttcta 4981 tggagttacc ctactgaatt gaatattgaa tagttaattt ctctctccaa tcattttccc 5041 cacctaattt tgaaagatat acatcatctg gggtaccctg tgccctacac agcatgtgaa 5101 gtggatgggt accccctaaa gagagggtca tcctgaatgg ggaagtggcc ccaaagctag 5161 gaataactgt gatttcttgt ctttagtcat gtgccaatgt taagtaagct tcagtggata 5221 gtgctgtcct accaagttcc ttgtagaagc cagccggatt ttcaacaggc agcattccac 5281 agcatttccc tgagcctgct tcaagagggg tgggggaagt cccttttcag gtgtttatct 5341 cctctgcatt tgtgtaatct ccctgaaggt ggataagcca agggcatgag ggggaggcaa 5401 aaggtgaact catgttaagg agggaaaaaa ataaagagcc cttttttctg tgtttcttgc 5461 tgatggcagg ctgtgtgctt catctgcttt tatctgctct gctagctctg actctactgt 5521 gatccagcat gtctctcggc gtttgaggag acatccccca ctgacctgct ctttctctcc 5581 ccagcagtct taggcgctga gctcagcgcg gtgggtgaga acggcgggga gaaacccact 5641 cccagtccac cctggcggct ccgccggtcc aagcgctgct cctgctcgtc cctgatggat 5701 aaagagtgtg tctacttctg ccacctggac atcatttggg tcaacactcc cgagtaagtc 5761 tctagagggc attgtaaccc tattcattca ttagcgctgg ctccactgga gcccagtttt 5821 agagtttctt ttctagggac tctgaaggta gtccttctaa caccatccaa gtgcctcagt 5881 ggggacagtt tccctctatt cctgaaaata acgacagctt cgttcttagc aaccaagggg 5941 agggtcttct gaggccccgt agctcaggct actcatgatg ggacaagcag gaggccactg 6001 cacgtttcaa atgaggaact ttcagtgaga gggcctcagg gggacactct cacagtggca 6061 tctgatgggg tttcgggaat aattgccgag gtcagatgtg ggttagtgca acctgtgctt 6121 ctcatgggag ggtggagact gagaggcaga agtgatgata tagagggtta gaatcactta 6181 attttagtta cagaaaaacc taggctcaaa gtgttgaagc catttgtgca ggagtgagtt 6241 tgtagcagag ctagaactgg agcccggatt tcctttgctg ctatattttc cctttagaaa 6301 tgcccatttc agaactgaaa tagaaatact gtccataggc ttctctttca cctacagaga 6361 agaaaagcag atttcctcct tctgccctgg acactagttc atcatctgtc ggaagcagtc 6421 ataaacaagc acacatttac tatgcataca atgtaccgtt atgacaaagg aggaccaaaa 6481 tccaaacaat atcaaaccac accaaaaacc acaaggagcc taataattac taaggtgata 6541 cttccaaagg gaggacttta tttcttagat gagaatgaaa atggacacat tggaaattat 6601 tggagagccc tctggctatg agtccttcca caaccatatg gtaccaccga ctggcaggag 6661 aaatgtgtga acatgtgcct cctctcccca accactgggg ccggtggggt gacggtggca 6721 cttttagcag tatcctccgt ggtttgagtt gaaaataagt tttaaaaatc ctgtgagtca 6781 tggttttgca ttgaaacctc ttcccactgt gtacccacaa atagttaact aaatagacca 6841 ttagaaaagg aagaaaatat aaagcagatg ccaagcagag atgtcctaat ttttgacaaa 6901 aaagcaatgt tgcttgtgtc aagaagaaac tgaactttgt gaagagttga aatggaattc 6961 cactgaatta gaaaaacttg ttttctcctg cctggataca tacagtcagg gccattgatg 7021 cacaggtgtt cctggctgtt gttacacttt accctctgaa atgatgctcc caagtgctat 7081 gtgatgagct ccttgtgtgc ccagtggaat aggtgtgtcc atgtgtcatt ttaaagacta 7141 ttaattacac taatatagtt tctttctctc tttggataat aggcacgttg ttccgtatgg 7201 acttggaagc cctaggtcca agagagcctt ggagaattta cttcccacaa aggcaacaga 7261 ccgtgagaat agatgccaat gtgctagcca aaaagacaag aagtgctgga atttttgcca 7321 agcaggaaaa gaactcaggt gagcagaaac acctttgctt ttcaatcagt ttaacagcct 7381 cctgaactcc ttcctatcat ggtactgcct tcctgtttta gagagactaa cagagacatt 7441 gaaagtcagg gtaaagctga atataacatt gctgaaatgt ttttccttgt gtattttaac 7501 agggctgaag acattatgga gaaagactgg aataatcata agaaaggaaa agactgttcc 7561 aagcttggga aaaagtgtat ttatcagcag ttagtgagag gaaqaaaaat cagaagaagt 7621 tcagaggaac acctaagaca aaccaggtaa gagggaagga agaaaaatta ggtaagaggt 7681 tcacaagaac aactagcccc agtcagtgat gccagcagcc tgttcctcca gcccttctta 7741 cccgggcagg tgaaagactt agaaaacagt agcagaggag atctatgcat cctatagatt 7801 aaaaggagca aaagaatccc tcttaaatat ttccatgaag ctctggaatg caaaccgatg 7861 tcctctgtac ctttagcaca taccatttca tctacaggta gatttcccaa ccaaaatata 7921 tccagagatg cctttgtcat tgggttatat acagcctttg cctctctgag tcaatgtatt 7981 taccactttc cctgagaaat cgaaaatcat tttggggagc ggacatttag aaaaagaatc 8041 aaagtgtcat ggataatcaa attcttcaat aagttgcagt tattcagatg gccaaaggaa WO 00/09525 PCT/US99/17712 EPI-109 1200 8101 aaataaagtc attagatagg gttggtagaa tttagaacat gctgtttttc aggtttatgg 8161 tctttttttt tttttttttt tttttttaaa tagggaaatg tgtttggtgc agagccaatg 8221 tcattccaaa aagctctctc ttttcctggt cagtcatgtg ctgggacaga gaagggatct 8281 ggattaggca acatcataga gttgctctga gctgctcttt ggtgataacc cttccaaatc 8341 ctaaactttt tggaattcac aagctcaaag gaggaaacct actctctgat ctaccacatg 8401 ttctgcattt ttctatcatg gtctatggaa acttctctta gaaatccagt ggcaagaagt 8461 tctatgatta aagtgttctg agctcaggcc aggcagtcat gaactacttc tgagttgttt 8521 actactgatt tgtggggcag cctcagctat cggtttcttc acacctgctt atgagagtat 8581 ccatatttat ggtcgcaggc agtaatgctc cccacgagat cagtttctga actaacctgg 8641 aattttttat gggtttttat tatgccaact attaaatcaa cattacagtt cttccctctg 8701 tatttctcct gtaaaacatt aggcctgcaa aaaaaaaaaa tctttttaaa aataattgcc 8761 ataaagtatt tgctctgggc ctactgtatg cttcttttyt ttttctctct tttcaactaa 8821 gtcaccgtca atttattaag atggccataa ctattcaaaa cctatgctga gttcctcaag 8881 gcagggtcgc atagtgatga aggttgggat ggggctacgg aagaaaccag aacaactcta 8941 gtttatttaa aacctgtatt tactgcccac ttccccttag acttgaccat atgacccctt 9001 gctccccatt ctaagcatag gggcaggctt tatttttaca atggtaatag atgatatcac 9061 ttgaggtttt atcaaagagt tgcggcgggt ggtgaaagtt cacaaccaga ttcaggtttt 9121 gtttgtgcca gattctaatt ttacatgttt cttttgccaa agggtgattt ttttaaaata 9181 acatttgttt tctcttatct tgctttatta ggtcggagac catgagaaac agcgtcaaat 9241 catcttttca tgatcccaag ctgaaaggca agccctccag agagcgttat gtgacccaca 9301 accgagcaca ttggtgacag accttcgggg cctgtctgaa gccatagcct ccacggagag 9361 ccctgtggcc gactctgcac tctccaccct ggctgggatc agagcaggag catcctctgc 9421 tggttcctga ctggcaaagg accagcgtcc tcgttcaaaa cattccaaga aaggttaagg 9481 agttccccca accatcttca ctggcttcca tcagtggtaa ctgctttggt ctcttctttc 9541 atctggggat gacaatggac ctctcagcag aaacacacag tcacattcga attcgggtgg 9601 catcctccgg agagagagag aggaaggaga ttccacacag gggtggagtt tctgacgaag 9661 gtcctaaggg agtgtttgtg tctgactcag gcgcctggca catttcaggg agaaactcca 9721 aagtccacac aaagattttc taaggaatgc acaaattgaa aacacactca aaagacaaac 9781 atgcaagtaa agaaaaaaaa aagaaagact tttgtttaaa tttgtaaaat gcaaaactga 9841 atgaaactgt tactaccata aatcaggata tgtttcatga atatgagtct acctcaccta 9901 tattgcactc tggcagaagt atttcccaca tttaattatt gcctccccaa actcttccca 9961 cccctgctgc cccttcctcc atcccccata ctaaatccta gcctcgtaga agtctggtct 10021 aatgtgtcag cagtagatat aatattttca tggtaatcta ctagctctga tccataagaa 10081 aaaaaagatc attaaatcag gagattccct gtccttgatt tttggagaca caatggtata 10141 gggttgttta tgaaatatat tgaaaagtaa gtgtttgtta cgctttaaag cagtaaaatt 10201 attttccttt atataaccgg ctaatgaaag aggttggatt gaattttgat gtacttattt 10261 ttttatagat atttatattc aaacaattta ttccttatat ttaccatgtt aaatatctgt 10321 ttgggcaggc catattggtc tatgtatttt taaaatatgt atttctaaat gaaattgaga 10381 acatgctttg ttttgcctgt caaggtaatg actttagaaa ataaatattt ttttccttac 10441 tgtactgatt tggaatcatt actgaaattt gtaaggagtg ggccaacgtg attaagtacc 10501 ataaaggcaa ataaatggtt aaagacggtt tcatagaaaa gtgacaatta gaaggatatt 10561 acggtctaag ctaattatat aaagaatttt atctgtatct taaatgttga ttttatactg 10621 cattgaggta aaaacacaaa acaaaaaagc agctttaaca cctctgtctt ctcttgggta 10681 gcagcctcct gcttctcctt cacctgaaaa attctccagg gacttcatcc attaacttgg 10741 ctcaggctat tggcaggatt cacagtttaa gctgatggtg tggtgagaga tgctttatcc 10801 atattaatgg actgaaggaa gtaatggcaa gacaaccccc caaaacatac ctaattatac 10861 aaagttatat accaaagttg cttttagaaa atggcctgct cagagcaagt agaggtttcc 10921 aatggctttt tattttctca cattaaggat gttgtttctt aaggaacatt gagtaccatt 10981 gcttcttcgt gatagcctag gactgccgtg tgcccatgga ggtagagaca ccaggtactg 11041 attctaggtc ctctgccaca aagcaccact tcctctccac tttgccttgg ctggccttgt 11101 cagctcactg gagagcacag tattgcaatt gcagtattgc aaatggtcac tactaactga 11161 attctctaag agcttgatta gccctcgaga atcttccttg cccttctcta atagtgtctg 11221 aaggaattcc tggcatttaa caaatattag catgtagtga tcactgtcgt cctaacagtg 11281 acacatcaga aggatttcaa ataacagtct tcaggcatgc gtaatcaatg tcctgtgcag 11341 agtctccgtc ctcattgatc ctcatttttc tctttaaggc acagtccaat gtctttgggg 11401 aattgtttat aaagcttact ttatccataa actgtttctc agtgcgtgac tctgaagaaa 11461 attttgaagt tttgcccatg ttgacaaggt gcttggtctg aacttggcca gtatttaatc 11521 ttgagcaaac gattcaattt ccttctatcg tgagttttct catctatgaa acaagggagt 11581 tgaggggagt ttctttcata cctctgagaa agagtttgag attacataaa gaagttgaag 11641 tggcatgaaa aaaaataaag atctgagctt agaagacatg gatctaatac atttaagagg 11701 aagtcagaat cagagaagcc actgaacaaa acagtccaaa cggagcatag taagtcagat 11761 tgatgagttt tggttgggtt tttcatcagt caaacccttg agcccccctt tcccatgctt 11821 cctgcttcag tatccagtag gaaaaatgaa agggatgatg tagacactct agggcatgag 11881 gatttgcagt aaataagttg ggagactcac agaaaattaa tatttttcaa acatgaagac 11941 gaaacattca attatattac agtccacatc agcttgaagg gtaaactgat gggatgatct 12001 gtcacatttc ttgctctgtt tccagtaaaa gcatggtttc tggaaaccca cttaggacag 12061 ctttctctct ttacactgat agcccaggca agctttgatc tcagaactcc agaaaccaga 12121 gaactctagg tggaatgtgg taacttttgc cagggcagag ggaacaccta ctaataggta WO 00/09525 PCTUS99/17712 EPI-109 1201 12181 cttcattzgc accaccagag attggcatct tttttgatgg atccactagc tttgatactg 12241 cctgtac-cc cccaaaacac agcttgggta ttggactaat ctagagctcc ctcaggagaa 12301 ctcttgctga cattaagaaa gagcaacatt ttgtctttcc aggtgaaaat ccaaggccaa 12361 aaagggagtg actcacctaa gatcacagaa ggagctgtag catctctgga gcctgaacac 12421 ttaagttaag cacgactatt tcacgcagag ggcatgaatt c (2) INFORMATION FOR SEQ ID NO:42: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1251 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:42: 1 ggagctgttt acccccactc taataggggt tcaatataaa aagccggcag agagctgtcc 61 aagtcagacg cgcctctgca tctgcgccag gcgaacgggt cctgcgcctc ctgcagtccc 121 agctctccac caccgccgcg tgcgcctgca gacgctccgc tcgctgcctt ctctcctggc 181 aggcgctgcc ttttctcccc gttaaagggc acttgggctg aaggatcgct ttgagatctg 241 aggaacccgc agcgctttga gggacctgaa gctgtttttc ttcgttttcc tttgggttca 301 gtttgaacgg gaggtttttg atcccttttt ttcagaatgg attatttgct catgattttc 361 tctctgctgt ttgtggcttg ccaaggagct ccagaaacag cagtcttagg cgctgagctc 421 agcgcggtgg gtgagaacgg cggggagaaa cccactccca gtccaccctg gcggctccgc 481 cggtccaagc gctgctcctg ctcgtccctg atggataaag agtgtgtcta cttctgccac 541 ctggacatca tttgggtcaa cactcccgag cacgttgttc cgtatggact tggaagccct 601 aggtccaaga gagccttgga gaatttactt cccacaaagg caacagaccg tgagaataga 661 tgccaatgtg ctagccaaaa agacaagaag tgctggaatt tttgccaagc aggaaaagaa 721 ctcagggctg aagacattat ggagaaagac tggaataatc ataagaaagg aaaagactgt 781 tccaagcttg ggaaaaagtg tatttatcag cagttagtga gaggaagaaa aatcagaaga 841 agttcagagg aacacctaag acaaaccagg tcggagacca tgagaaacag cgtcaaatca 901 tcttttcatg atcccaagct gaaaggcaag ccctccagag agcgttatgt gacccacaac 961 cgagcacatt ggtgacagac ttcggggcct gtctgaagcc atagcctcca cggagagccc 1021 tgtggccgac tctgcactct ccaccctggc tgggatcaga gcaggagcat cctctgctgg 1081 ttcctgactg gcaaaggacc agcgtcctcg ttcaaaacat tccaagaaag gttaaggagt 1141 tcccccaacc atcttcactg gcttccatca gtggtaactg ctttggtctc ttctttcatc 1201 tggggatgac aatggacctc tcagcagaaa cacacagtca cattcgaatt c (2) INFORMATION FOR SEQ ID NO:43: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1166 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:43: 1 ctgcgccagg cgaacgggtc ctgcgcctcc tgcagtccca gctctccacc gccgcgtgcg 61 cctgcagacg ctccgctcgc tgccttctct cctggcaggc gctgcctttt ctccccgtta 121 aagggcactt gggctgaagg atcgctttga gatctgagga acccgcagcg ctttgaggga 181 cctgaagctg tttttcttcg ttttcctttg ggttcagttt gaacgggagg tttttgatcc 241 ctttttttca gaatggatta tttgctcatg attttctctc tgctgtttgt ggcttgccaa 301 ggagctccag aaacagcagt cttaggcgct gagctcagcg cggtgggtga gaacggcggg 361 gagaaaccca ctcccagtcc accctggcgg ctccgccggt ccaagcgctg ctcctgctcg 421 tccctgatgg ataaagagtg tgtctacttc tgccacctgg acatcatttg ggtcaacact 481 cccgagcacg ttgttccgta tggacttgga agccctaggt ccaagagagc cttggagaat 541 ttacttccca caaaggcaac agaccgtgag aatagatgcc aatgtgctag ccaaaaagac 601 aagaagtgct ggaatttttg ccaagcagga aaagaactca gggctgaaga cattatggag 661 aaagactgga ataatcataa gaaaggaaaa gactgttcca agcttgggaa aaagtgtatt 721 tatcagcagt tagtgagagg aagaaaaatc agaagaagtt cagaggaaca cctaagacaa 781 accaggtcgg agaccatgag aaacagcgtc aaatcatctt ttcatgatcc caagctgaaa 841 ggcaagccct ccagagagcg ttatgtgacc cacaaccgag cacattggtg acagacttcg 901 gggcctgtct gaagccatag cctccacgga gagccctgtg gccgactctg cactctccac 961 cctggctggg atcagagcag gagcatcctc tgctggttcc tgactggcaa aggaccagcg 1021 tcctcgttca aaacattcca agaaaggtta aggagttccc ccaaccatct tcactggctt 1081 ccatcagtgg taactgcttt ggtctcttct ttcatctggg gatgacaatg gacctctcag 1141 cagaaacaca cagtcacatt cgaattc (2) INFORMATION FOR SEQ ID NO:44: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14878 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:44: 1 gatatactat taatacagag atacagaaag aaatacataa aaaatagttt tatcaaatac 61 tttccagcat tcaagtgtag cctccaaaagc aagaataggc caggagtggt ggctcacgct 121 gtaatccaca gcactgtggg aggccaaggt aagaggattg cttgaggcca ggatttcaag 181 accagcctag gcaacatagt gagatcccta tctctacgaa aaaattttaa aacttagctg WO 00/09525 PCT/US99/17712 EPI-109 1202 241 ggcatggrgc ittaagcctgt tgtcccagct actcaggagg tgaagtagga gtgtcacttg 301 agcccaggag gztgaggctg cagtgagcta taactgcacc actacactcc agccttggag 361 acagagtgag accctgtccc caaaaaaatt aaaattgaga aaaaaaaaaa ggcaagaaca 421 gccacagcaa actttctatt ggggaaaaaa aaaaatcctc ctctttacat ctctcccttc 481 cttcccttcc ctttctgaga gtgactgtgg ccaaaaggag cattitcccc ctgcagtcct 541 ctgaggggtg gggtggggct atgaagctat ccttcatatt cactcctttg tccagctctt 601 ttcacctcta gttcttctcc ccgcatctct gtctagcagt gccttaagtg gaggaggggt 661 gggggcatca agcttgtaaa actggtttgt tggggttctc cttctcccct catttcttga 721 ttcttgggaa aatgtcttgc tgggaggctg cctggcgagt gccctagctg ccttctgtgg 781 gcttgaatgg ggcttccctc tgcccctaca ggaggaaaaq ggagctgctg ccagagggag 841 aaatggagag atggacagag aaqgcaggtg ccacccctcg cccctgacac acaaagaaaa 901 agacacggaa attctctctc tctcttctct tctcctatct ctctctctct ccctctctCt 961 ctctctctct ctctctctca cacacacaca cacacacaca cacacacaca caggcgcgcg 1021 ccgcgcgcgc aggcacacgt cttgcaaatt caggattcaa agagacaggg gcaccattat 1081 atttggcacg gtggggcctt ccaggtctga aatcctgcat tcttccttac tatttacttt 1141 ccccgagctc gagaagggcc aggtgtgggc ggatggctgg ccacgttttg tgtttccaat 1201 tcatattcac gggatgacac agacggggcg tggtgagtgc tgttggaggc gcttgggcag 1261 tttcattttg ccccacttct ccacctgaag gctgggcgtt gctggaacct gcaggggcag 1321 cctcagcaag gtggggtggc gtggagtggg gtgggagaag ggactccagc tgaagtagaa 1381 cccaggctgg acctgagaat attggggagg gcatgggcgg tggtttccgg gtaggggcct 1441 tgaggacatg ttggtcctga ctgttgtcag tgtttggtca aagttgccaa aaggttaaaa 1501 aaaaaaaagt agggggagtc cctgccaaga catatttccC aggccacctt tcttccgcgg 1561 gagtgttggg ggggaggcgc tgcttggaac ctgtgaatgt gacatcagct ctcctctcct 1621 ctcccaaggt cggctttgga gagggaggtc agggcaccct tgcctggcac aggcacgctg 1681 gcttccggct cagtgccgcc tgctctccgg gagctgtgcg ctccctgggc cccggggcta 1741 ggctgaggta agcgcacagc ggaggccagg cgcgccggca gaggcctggg ggatagggtg 1801 gaggcatctc tgggtgtggg tgtgggtgtg ggtgtgggag ggagagttct tgcctctctc 1861 tctcccatct ccaactcttg cttcagtggc tcttttagag gatgcatgtc attatggacc 1921 tgtcgctgcc actgtccctg ttcccccagc tgtgacttcg agggaggtct ggggatctga 1981 gtctgtccaa acccacggct ttgctgttgg gataaaaact gtccttttga ttttagaagg 2041 aggagggaaa aaaggtttcc cagcatgtgt gttgtgccag tcttggaaat tcatccgtgc 2101 ttgaattcca ccctccatcc ccagaaaaac tggagtaaaa caaaaagagg agatggacaa 2161 agtgtgtatt tgatggcatc ccctgggaag agactctaaa tttatcccat aggtcttact 2221 gggccactgt gagcgctttg gtggagaaca aacaaaaatt ctgggtgctc agttgtctaa 2281 cctgaaaaat gggactagcg gaaaaagcca atgtgttcca tgcacctttt gctttcttta 2341 ttaaggcatg atgtcacctg tacagtaact gccctgtgtg tacttcaggg ggggatttca 2401 aggttagata gacaggaaat tgttttgaaa atgtaaacac attattaaat gtgaagtatt 2461 atctgattcc ttgttcgaat ggcatttcct tctcagcacc accttccttg catattcact 2521 taaccttgta caagaacacc tttttgccct aaatgaagac acccccccaa aaaaaagagt 2581 cccagaaaat atgtccctgc ttgtgcggga ataaatagaa tattctgagg tgcattcctc 2641 cttcctatgt taggcaacat tccttgaccc tcctcggccc ccaagccagg ttgcgttttt 2701 ttctgccatt tagaagggtt ttcctttttg tcctagtaaa acatcagccc ctgtagctct 2761 tcatctcccc ctggtgttct tctcccgcca tgtcttaaga ttggtggcac cgaccaatct 2821 taagatttaa gttctgtgtg aaaaacacct ttgcttttca atcagtttat cagcctcctc 2881 cgcaggggaa tgtggacaca caaaagaact tatcggggct tctcatcagt gatagggaaa 2941 agactggcat gtgcctaaac gagctctgat gttattttta agctcccttt cttgccaatc 3001 cctcacggat ctttctccga tagatgcaaa gaacttcagc aaaaaagacc cgcaggaagg 3061 ggcttgaaga gaaaagtacg ttgatctgcc aaaatagtct gacccccagt agtgggcagt 3121 gacgagggag agcattccct tgtttgactg agactagaat cggagagaca taaaaggaaa 3181 atgaagcgag caacaattaa aaaaaattcc ccgcacacaa caatacaatc tatttaaact 3241 gtggctcata cttttcatac caatggtatg actttttttc tggagtcccc tcttctgatt 3301 cttgaactcc ggggctggca gcttgcaaag gggaagcgga ctccagcact gcacgggcag 3361 gtttagcaaa ggtctctaat gggtattttc tttttcttag ccctgccccc gaattgtcag 3421 acggcgggcg cctgcttctg aagttagcag tgatttcctt tcgggcctgg cttatctccg 3481 gctgcacgtt gcctgttggt gactaataac acaataacat tgtctggggc tggaataaag 3541 tcggagctgt ttacccccac tctaataggg gttcaatata aaaagccggc agagagctgt 3601 ccaagtcaga cgcgcctctg catctgcgcc aggcgaacgg gtcctgcgcc. tcctgcagtc 3661 ccagctctcc accgccgcgt gcgcctgcag acgctccgct cgctgccttc tctcctggca 3721 ggcgctgcct tttctccccg ttaaagggca cttgggctga aggatcgctt tgagatctga 3781 ggaacccgca gcgctttgag ggacctgaag ctgtttttct tcgttttcct ttgggttcag 3841 tttgaacggg aggtttttga tccctttttt tcagaatgga ttatttgctc atgattttct 3901 ctctgctgtt tgtggcttgc caaggagctc cagaaacagg taggcacgct cgttgacttg 3961 taagtctcgg aattacaagt tagtgtgttc ttatccacct tcatgctttt cttgcttcta 402.1 tttttccccg ttctttttat gactgcagct tagagagcaa gtgtctgaga attattgctg 4081 aaacgtactt taagtcttct agtgtaaaat gtaaaattcc tctactgaat acaattaggt 4141 gcaattgact ataacatgac attaaaataa cttatcgttt tattattatt attccattat 4201 gtgtttcctt ggcttttaaa aaatgagaag agtatggaca tatacaattt agtcaaatgt 4261 atgtttgtaa tatatgtgtt tatacaggta cacaggccat ataggaactt aaatcttatt 4321 taaacactat tttaatagtg tgttaacgtg taaaatattt aagcattcca gcttgaagcc 4381 aaggaattgt atccagtcgt tcaagcaatg tatgttcagt aaaatcacct gcagagcaaa 4441 agtctgttga ctaactaccg cctcccccgc ccccccacca ccccccgcag gcggtttctg 4501 ggtgaagcag atgttttctt taaaatttgt catcattgac tttaggtttc ttttggcagg 4561 tttttggcac ccaaaacagt gtgagctctc ttttcagctt tattcacctg tgctgggagg 4621 ggagctagga taatcttgg ctgccgaagg atttaggcag tgcgtgtgca tctgcccggg 4681 tcccccccgt ttttagggtc agtgcacttt ttttgtcttt tcgtgaccct gactaaagag WO 00/09525 PCT/US99/17712 EPI-109 1203 4741 aaaggatgtc aagggaatga aaatcctaga atgtgtctga tcatttgaaa tgtacaaaat 4801 tgggcagata agctgcatgq ctaaattgtt aggaggaaga ggcaaggcag tagtggagaa 4861 gggggaggca gtggatccca cacaagcctg atgcccaggg attcggaatt caaaatcccc 4921 ccagcctacc ttcagtcccc tgacctgctt ctcagcccca ccttaggtca ctggtttcta 4981 tggagttacc ctactgaatt gaatattgaa tagttaattt ctctctccaa tcattttccc 5041 cacctaattt tgaaagatat acatcatctg gggtaccctg tgccctacac agcatgtgaa 5101 gtggatgggt accccctaaa gagagggtca tcctgaatgg ggaagtggcc ccaaagctag 5161 gaataactgt gatttcttgt ctttagtcat gtgccaatgt taagtaagct tcagtggata 5221 gtgctgtcct accaagttcc ttgtagaagc cagccggatt ttcaacaggc agcattccac 5281 agcatttccc tgagcctgct tcaagagggg tgggggaagt cccttttcag gtgtttatct 5341 cctctgcatt tgtgtaatct ccctgaaggt ggataagcca agggcatgag ggggaggcaa 5401 aaggtgaact catgttaagg agggaaaaaa ataaagagcc cttttttctg tgtttcttgc 5461 tgatggcagg ctgtgtgctt catctgcttt tatctgctct gctagctctg actctactgt 5521 gatccagcat gtctctcggc gtttgaggag acatccccca ctgacctgct ctttctctcc 5581 ccagcagtct taggcgctga gctcagcgcg gtgggtgaga acggcgggga gaaacccact 5641 cccagtccac cctggcggct ccgccggtcc aagcgctgct cctgctcgtc cctgatggat 5701 aaagagtgtg tctacttctg ccacctggac atcatttggg tcaacactcc cgagtaagtc 5761 tctagagggc attgtaaccc tattcattca ttagcgctgg ctccactgga gcccagtttt 5821 agagtttctt ttctagggac tctgaaggta gtccttctaa caccatccaa gtgcctcagt 5881 ggggacagtt tccctctatt cctgaaaata acgacagctt cgttcttagc aaccaagggg 5941 agggtcttct gaggccccgt agcccaggct actcatgatg ggacaagcag gaggccactg 6001 cacgtttcaa atgaggaact ttcagtgaga gggcctcagg gggacactct cacagtggca 6061 tctgatgggg tttcgggaat aattgccgag gtcagatgtg ggttagtgca acctgtgctt 6121 ctcatgggag ggtggagact gagaggcaga agtgatgata tagagggtta gaatcactta 6181 attttagtta cagaaaaacc taggctcaaa gtgttgaagc catttgtgca ggagtgagtt 6241 tgtagcagag ctagaactgg agcccggatt tcctttgctg ctatattttc cctttagaaa 6301 tgcccatttc agaactgaaa tagaaatact gtccataggc ttctctttca cctacagaga 6361 agaaaagcag atttcctcct tctgccctgg acactagttc atcatctgtc ggaagcagtc 6421 ataaacaagc acacatttac tatgcataca atgtaccgtt atgacaaagg aggaccaaaa 6481 tccaaacaat atcaaaccac accaaaaacc acaaggagcc taataattac taaggtgata 6541 cttccaaagg gaggacttta tttcttagat gagaatgaaa atggacacat tggaaattat 6601 tggagagccc tctggctatg agtccttcca caaccatatg gtaccaccga ctggcaggag 6661 aaatgtgtga acatgtgcct cctctcccca accactgggg ccggtggggt gacggtggca 6721 cttttagcag tatcctccgt ggtttgagtt gaaaataagt tttaaaaatc ctgtgagtca 6781 tggttttgca ttgaaacctc ttcccactgt gtacccacaa atagttaact aaatagacca 6841 ttagaaaagg aagaaaatat aaagcagatg ccaagcagag atgtcctaat ttttgacaaa 6901 aaagcaatgt tgcttgtgtc aagaagaaac tgaactttgt gaagagttga aatggaattc 6961 cactgaatta gaaaaacttg ttttctcctg cctggataca tacagtcagg gccattgatg 7021 cacaggtgtt cctggctgtt gttacacttt accctctgaa atgatgctcc caagtgctat 7081 gtgatgagct ccttgtgtgc ccagtggaat aggtgtgtcc atgtgtcatt ttaaagacta 7141 ttaattacac taatatagtt tctttctctc tttggataat aggcacgttg ttccgtatgg 7201 acttggaagc cctaggtcca agagagcctt ggagaattta cttcccacaa aggcaacaga 7261 ccgtgagaat agatgccaat gtgctagcca aaaagacaag aagtgctgga atttttgcca 7321 agcaggaaaa gaactcaggt gagcagaaac acctttgctt ttcaatcagt ttaacagcct 7381 cctgaactcc ttcctatcat ggtactgcct tcctgtttta gagagactaa cagagacatt 7441 gaaagtcagg gtaaagctga atataacatt gctgaaatgt ttttccttgt gtattttaac 7501 agggctgaag acattatgga gaaagactgg aataatcata agaaaggaaa agactgttcc 7561 aagcttggga aaaagtgtat ttatcagcag ttagtgagag gaagaaaaat cagaagaagt 7621 tcagaggaac acctaagaca aaccaggtaa gagggaagga agaaaaatta ggtaagaggt 7681 tcacaagaac aactagcccc agtcagtgat gccagcagcc tgttcctcca gcccttctta 7741 cccgggcagg tgaaagactt agaaaacagt agcagaggag atctatgcat cctatagat 7801 aaaaggagca aaagaatccc tcttaaatat ttccatgaag ctctggaatg caaaccgatg 7861 tcctctgtac ctttagcaca taccatttca tctacaggta gatttcccaa ccaaaatata 7921 tccagagatg cctttgtcat tgggttatat acagcctttg cctctctgag tcaatgtatt 7981 taccactttc cctgagaaat cgaaaatcat tttggggagc ggacatttag aaaaagaatc 8041 aaagtgtcat ggataatcaa attcttcaat aagttgcagt tattcagatg gccaaaggaa 8101 aaataaagtc attagatagg gttggtagaa tttagaacat gctgtttttc aggtttatgg 8161 tctttttttt tttttttttt tttttttaaa tagggaaatg tgtttggtgc agagccaatg 8221 tcattccaaa aagctctctc ttttcctggt cagtcatgtg ctgggacaga gaagggatct 8281 ggattaggca acatcataga gttgctctga gctgctcttt ggtgataacc cttccaaatc 8341 ctaaactttt tggaattcac aagctcaaag gaggaaacct actctctgat ctaccacatg 8401 ttctgcattt ttctatcatg gtctatggaa acttctctta gaaatccagt ggcaagaagt 8461 tctatgatta aagtgttctg agctcaggcc aggcagtcat gaactacttc tgagttgttt 8521 actactgatt tgtggggcag cctcagctat cggtttcttc acacctgctt atgagagtat 8581 ccatatttat ggtcgcaggc agtaatgctc cccacgagat cagtttctga actaacctgg 8641 aattttttat gggtttttat tatgccaact attaaatcaa cattacagtt cttccctctg 8701 tatttctcct gtaaaacatt aggcctgcaa aaaaaaaaaa tctttttaaa aataattgcc 8761 ataaagtatt tgctctgggc ctactgtatg cttcttttyt ttttctctct tttcaactaa 8821 gtcaccgtca atttattaag atggccataa ctattcaaaa cctatgctga gttcctcaag 8881 gcagggtcgc atagtgatga aggttgggat ggggctacgg aagaaaccag aacaactcta 8941 gtttatttaa aacctgtatt tactgcccac ttccccttag acttgaccat atgacccctt 9001 gctccccatt ctaagcatag gggcaggctt tatttttaca atggtaatag atgatatcac 9061 ttgaggtttt atcaaagagt tgcggcgggt ggtgaaagtt cacaaccaga ttcaggtttt 9121 gtttgtgcca gattctaa t ttacatgttt cttttgccaa agggtgattt ttttaaaata 9181 acatttgttt tctcttatct tgctttatta ggtcggagac catgagaaac agcgtcaaat WO 00/09525 PCTIUS99/17712 EPI-109 1204 9241 catcttztca tgatcccaaa otgaaaggca agccctccag agagcgttat gtgacccaca 9301 accgagcaca ttggtgacaa accttcgggg cctgtct-aa gccatagcct ccacggagag 9361 ccctgtggcc gactctac tctccaccct ggctgggatc agagcaggag catcctctgc 9421 tggttcc-ga ctggcaaagg accagcgtcc tcgttcaaaa cattccaaga aaggttaagg 9481 agttccccca accatctzca ctggcttcca tcagtggtaa ctgctttggt ctCttctttc 9541 atctggggat gacaatggac ctctcagcag aaacacacag tcacattcga attcgggtgg 9601 catcctccgg agagagagag aggaaggaga ttccacacag gggtggagtt tctgacgaag 9661 gtcctaaggg agtgtttazg tctgactcag gcgcctggca catttcaggg agaaactcca 9721 aagtccacac aaagattvtc taaggaatgc acaaattgaa aacacactca aaagacaaac 9781 atgcaaataa agaaaaaaaa aagaaagact tttgtttaaa tttgtaaaat gcaaaactga 9841 atgaaactgt tactaccata aatcaggata tgtttcatga atatgagtct acctcaccta 9901 tattgcactc tggcagaagt atttcccaca tttaattatt gcctccccaa actcttccca 9961 cccctgctgc cccttcctcc atcccccata ctaaatccta gcctcgtaga agtctggtct 10021 aatgtgtcag cagtagatat aatattttca tggtaatcta ctagctctga tccataagaa 10081 aaaaaagatc attaaatcag gagattccct gtccttgatt tttggagaca caatggtata 10141 gggttgttta tgaaatatat tgaaaagtaa gtgtttgtta cgctttaaag cagtaaaatt 10201 attttccttt atataaccgg ctaatgaaag aggttggatt gaattttgat gtacttattt 10261 ttttatagat atttatattc aaacaattta ttccttatat ttaccatgtt aaatatctgt 10321 ttgggcaggc catattggtc tatgtatttt taaaatatgt atttctaaat gaaattgaga 10381 acatgctttg ttttgcctgt caaggtaatg actttagaaa ataaatattt ttttccttac 10441 tgtactgatt tggaatcatt actgaaattt gtaaggagtg ggccaacgtg attaagtacc 10501 ataaaggcaa ataaatggtt aaagacggtt tcatagaaaa gtgacaatta gaaggatatt 10561 acggtctaag ctaattatat aaagaatttt atctgtatct taaatgttga ttttatactg 10621 cattgaggta aaaacacaaa acaaaaaagc agctttaaca cctctgtctt ctcttgggta 10681 gcagcctcct gcttctcctt cacctgaaaa attctccagg gacttcatcc attaacttgg 10741 ctcaggctat tggcaggatt cacagtttaa gctgatggtg tggtgagaga tgctttatcc 10801 atattaatgg actgaaggaa gtaatggcaa gacaaccccc caaaacatac ctaattatac 10861 aaagttatat accaaagttg cttttagaaa atggcctgct cagagcaagt agaggtttcc 10921 aatggctttt tattttctca cattaaggat gttgtttctt aaggaacatt gagtaccatt 10981 gcttcttcgt gatagcctaa gactgccgtg tgcccatgga ggtagagaca ccaggtactg 11041 attctaggtc ctctgccaca aagcaccact tcctctccac tttgccttgg ctggccttgt 11101 cagctcactg gagagcacag tattgcaatt gcagtattgc aaatggtcac tactaactga 11161 attctctaag agcttgatta gccctcgaga atcttccttg cccttctcta atagtgtctg 11221 aaggaattcc tggcatttaa caaatattag catgtagtga tcactgtcgt cctaacagtg 11281 acacatcaga aggatttcaa ataacagtct tcaggcatgc gtaatcaatg tcctgtgcag 11341 agtctccgtc ctcattgatc ctcatttttc tctttaaggc acagtccaat gtctttgggg 11401 aattgtttat aaagcttact ttatccataa actgtttctc agtgcgtgac tctgaagaaa 11461 attttgaagt tttgcccatg ttgacaaggt gcttggtctg aacttggcca gtatttaatc 11521 ttgagcaaac gattcaattt ccttctatcg tgagttttct catctatgaa acaagggagt 11581 tgaggggagt ttctttcata cctctgagaa agagtttgag attacataaa gaagttgaag 11641 tggcatgaaa aaaaataaag atctgagctt agaagacatg gatctaatac atttaagagg 11701 aagtcagaat cagagaagcc actgaacaaa acagtccaaa cggagcatag taagtcagat 11761 tgatgagttt tggttgggtt tttcatcagt caaacccttg agcccccctt tcccatgctt 11821 cctgcttcag tatccagtag gaaaaatgaa agggatgatg tagacactet agggcatgag 11881 gatttgcagt aaataagttg ggagactcac agaaaattaa tatttttcaa acatgaagac 11941 gaaacattca attatattac agtccacatc agcttgaagg gtaaactgat gggatgatct 12001 gtcacatttc ttgctctgtt tccagtaaaa gcatggtttc tggaaaccca cttaggacag 12061 ctttctctct ttacactgat agcccaggca agctttgatc tcagaactcc agaaaccaga 12121 gaactctagg tggaatgtgg taacttttgc cagggcagag ggaacaccta ctaataggta 12181 cttcatttgc accaccagag attggcatct tttttgatgg atccactggc tttgatactg 12241 cctgtactcc cccaaaacac agcttgggta ttggactaat ctagagctcc ctcaggagaa 12301 ctcttgctga cattaagaaa gagcaacatt ttgtctttcc aggtgaaaat ccaaggccaa 12361 aaagggagtg actcacctaa gatcacagaa ggagctgtag catctctgga gcctgaacac 12421 ttaagttaag cacgactatt tcacgcagag ggcatgaatt c ggagctgttt acccccactc taataggggt tcaatataaa aagccggcag agagctgtc 61 aagtcagacg cgcctcgca tctgcgccag gcgaacgggt cctgcgcctc ctgcagtccc 121 agctctccac caccgccgcg tgcgcctgca gacgctccgC tcgctgcctt ctctcctggc 181 aggcgctgcc ttttctcccc gttaaagggc acttgggctg aaggatcgct ttgagatctg 241 aggaacccgc agcgctttga gggacctgaa gctgtttttc ttcgttttcc tttgggttca 301 gtttgaacgg gaggtttttg atcccttttt ttcagaatgg attatttgct catgattttc 361 tctctgctgt ttgtggcttg ccaaggagct ccagaaacag cagtcttagg cgctgagctc 421 agcgcggtgg gtgagaacgg cggggagaaa cccactccca gtccaccctg gcggctccgc 481 cggtccaagc gctgctcctg ctcgtccctg atggataaag agtgtgtcta cttctgccac 541 ctggacatca tttgggtcaa cactcccgag cacgttgttc cgtatggact tggaagccct 601 aggtccaaga gagccttgga gaatttactt cccacaaagg caacagaccg tgagaataga 661 tgccaatgtg ctagccaaaa agacaagaag tgctggaatt tttgccaagc aggaaaagaa 721 ctcagggctg aagacattag ggagaaagac tggaataatc ataagaaagg aaaagactgt 781 tccaagcttg ggaaaaaatg tatttatcag cagttagtga gaggaagaaa aatcagaaga 841 agttcagagg aacacctaag acaaaccagg tcggagacca tgagaaacag cgtcaaatca 901 tcttttcatg atcccaagct gaaaggcaag ccctccagag agcgttatgt gacccacaac 961 cgagcacatt ggtgacagac ttcggggcct gtctgaagcc atagcctcca cggagagccc 1021 tgtggccgac tctgcactct ccaccctggc tgggatcaga gcaggagcat cctctgctgg 1081 ttcctgactg gcaaaggacc agcgtcctcg ttcaaaacat tccaagaaag gttaaggagt 1141 tcccccaacc atcttcacctg gcttccatca gtggtaact ctttggtctc ttctttcatc 1201 tggggatgac aatggacctc tcagcagaaa cacacagtca cattcgaatt c WO 00/09525 PCT/US99/17712 EPI-109 1205 1 ctgcgccagg cgaacgggtc ctgcgcctcc tgcagtccca gctctccacc gccgcgtgcg 61 cctgcagacg ctccgctcgc tgccttctct cctggcaggc gczacttt ctccccgtta 121 aagggcaczt gggctgaagg atcctttga gatctgagga acccgcagcg ctttgaggga 181 cctgaagctg tttttcttcg ttttcctttg ggttcagttt gaacgggagg tttttgatcc 241 ctttttttca gaatggacta tttgctcatg attttctctc tgczgtttgt ggcttgccaa 301 ggagctccag aaacagcagt cttaggcgct gagctcagcg cggtgggtga gaacggcggg 361 gagaaaccca ctcccagtcc accctggcgg ctccgccggt ccaagcgctg ctcctgctcg 421 tccctgatag ataaagagtg tgtctacttc tgccacctgg aca::catttg ggtcaacact 481 cccgagcacg ttgttccgta tggacttgga agccctaggt ccaagagagc cttggagaat 541 ttacttccca caaaggcaac agaccgtgag aatagatgcc aa7-atgctag ccaaaaagac 601 aagaagtgct ggaatttttg ccaagcagga aaagaactca gggctgaaga cattatggag 661 aaagactaga ataatcataa gaaaggaaaa gactgttcca agcztgggaa aaagtgtatt 721 tatcagcagt tagtgagagg aaaaaaaatc agaagaagtt cagaggaaca cctaagacaa 781 accaggtcgg agaccatgag aaacagcgtc aaatcatctt ttcatgatcc caagctgaaa 841 ggcaagccct ccagagagcg ttatgtgacc cacaaccgag cacattggtg acagacttcg 901 gggcctgtct gaagccatag cctccacgga gagccctgtg gccgactctg cactctccac 961 cctggctggg atcagagcag gagcatcctc tgctggttcc tgactggcaa aggaccagog 1021 tcctcgttca aaacattcca agaaaggtta aggagttccc ccaaccarct tcactggctt 1081 ccatcagtgg taactgcttt ggtctcttct ttcatctggg gatgacaatg gacctctcag 1141 cagaaacaca cagtcacatt cgaattc (2) INFORMATION FOR SEQ ID NO:45: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 718 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:45: 1 aggggcagct ggatcagttc tcacaggagc cacagctcag agactgggaa acatggttcc 61 aaaactgttc acttcccaaa tttgtctgct tcttctgttg gggcttatgg gtgtggaggg 121 ctcactccat gccagacccc cacagtttac gagggctcag tggtttgcca tccagcacat 181 cagtctgaac ccccctcgat gcaccattgc aatgcgggca attaacaatt atcgatggcg 241 ttgcaaaaac caaaatactt ttcttcgtac aacttttgct aatgtagtta atgtttgtgg 301 taaccaaagt atacgctgcc ctcataacag aactctcaac aattgtcatc ggagtagatt 361 ccgggtgcct ttactccact gtgacctcat aaatccaggt gcacagaata tttcaaactg 421 caggtatgca gacagaccag gaaggaggtt ctatgtagtt gcatgtgaca acagagatcc 481 acgggattct ccacggtatc ctgtggttcc agttcacctg gataccacca tctaagctcc 541 tgtatcagca gtcctcatca tcactcatct gccaagctcc tcaatcatag ccaagatccc 601 atccctccat gtactctggg tatcagcaac tgtcctcatc agtctccata ccccttcagc 661 tttcctgagc tgaagtccct tgtgaaccct gcaataaact gctttgcaaa ttcaaaaa (2) INFORMATION FOR SEQ ID NO:46: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 725 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:46: 1 gaacaaccag ctggatcagt tctcacagga gccacagctc agagactggg aaacatggtt 61 ccaaaactgt tcacttccca aatttgtctg cttcttctgt tggggcttat gggtgtggag 121 ggctcactcc atgccagacc cccacagttt acgagggctc agtggtttgc catccagcac 181 atcagtctga acccccctcg atgcaccatt gcaatgcggg caattaacaa ttatcgatgg 241 cgttgcaaaa accaaaatac ttttcttcgt acaacttttg ctaatgtagt taatgtttgt 301 ggtaaccaaa gtatacgctg ccctcataac agaactctca acaattgtca tcggagtaga 361 ttccgggtgc ctttactcca ctgtgacctc ataaatccag gtgcacagaa tatttcaaac 421 tgcaggtatg cagacagacc aggaaggagg ttctatgtag ttgcatgtga caacagagat 481 ccacgggatt ctccacggta tcctgtggtt ccagttcacc tggataccac catctaagct 541 cctgtatcag cagtcctcat catcactcat ctgccaagct cctcaatcat agccaagatc 601 ccatccctcc atgtactctg ggtatcagca actgtcctca tcagtctcca taccccttca 661 gctttcctga gctgaagtcc cttgtgaacc ctgcaataaa ctgctttgca aattc (2) INFORMATION FOR SEQ ID NO:47: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1452 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:47: 1 ctgccagcag cgtatagttt tcacccagag tccagatccc accggcaaaa ctctgtctaa 61 cacaggatga cttggaatta gagtccgtat agcagaaaga gcagcagggc tgtccttggg 121 tatccgttgc tcagccaagt catcaaataa aaaggatgat tgcacaagtg gaccatgtgt 181 caatctgtgg gtttctgcat ggccagaccc accaagggaa gctttattta aacagttcca 241 agtaggggag accagctgcc cctgaacccc agaacaacca gctggatcag ttctcacagg 301 agccacagct cagagactgg gtaagtcaac aatccccaga gctgggacau gaggggcagc 361 gacagggcag cacctgaggg agaggtgagc tgaagttagt gcttaggaga tgtggcacac WO 00/09525 PCT/US99/17712 EPI-109 1206 421 ttzagggaca aqaagaaaag gaaatacgac cccagagtgg cagcagaggg gcctgtgggt 481 tgagacacza Lagagtgtgt cataaccaag accggatagg ggagtagtta cttctcttct 541 tttcttacag gaaacatggt tccaaaactg ttcacttccc aaatttgtct gcttcttctg 601 ttggggctta tgggtgtgga gggctcactc catgccagac ccccacagtt tacgagggct 661 cagtggtttg ccatccagca catcagtctg aacccccctc gatgcaccat tgcaatgcgg 721 gcaattaaca attatcgatg gcgttgcaaa aaccaaaata cttttcttcg tacaactttt 781 gctaatgtag ttaatgtttg tggtaaccaa agtatacgct gccctcataa cagaactctc 841 aacaattgtc atcggagtag attccgggtg cctttactcc actgtgacct cataaatcca 901 ggtgcacaga atatttcaaa ctgcaggtat gcagacagac caggaaggag gttctatgta 961 gttgcatgtg acaacagaga tccacgggat tctccacggt atcctgtggt tccagttcac 1021 ctggatacca ccatctaagc tcctgtatca gcagtcctca tcatcactca tctgccaagc 1081 tcctcaatca tagccaagat cccatccctc catgtactct gggtatcagc aactgtcctc 1141 atcagtctcc ataccccttc agctttcctg agctgaagtc ccttgtgaac cctgcaataa 1201 actgctttgc aaattcatct ggaagtgtct gtgtgtcttc ctcggccgct ctgctgtcat 1261 ttagtgacaa tctgctctag agatttgggt ttatcatgaa tctctccccc tcaatatctg 1321 accaaattcc ttgattcccc catcatcctt catgtgatac ctgattccag gcctgcctta 1381 aaaaaaaatc caattgagtc aacttagcat tggtctccct agccttaata tctcctctaa 1441 gcaattttcc at (2) INFORMATION FOR SEQ ID NO:48: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 2395 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:48: 1aggggcagct ggatcaattc tcacaggagc cacagctcag agactgggaa acatggttcc 61 aaaactgttc acttcccaaa tttgtctgct tcttctgttg gggcttatgg gtgtggaggg 121 ctcactccat gccagacccc cacagtttac gagggctcag tggtttgcca tccagcacat 181 cagtctgaac ccccctcgat gcaccattgc aatgcgggca attaacaatt atcgatggcg 241 ttgcaaaaac caaaatacct ttcttcgtac aacttttgct aatgtagtta atgtttgtgg 301 taaccaaagt atacgctgcc ctcataacag aactctcaac aattgtcatc ggagtagatt 361 ccgggtgcct ttactccact gtgacctcat aaatccaggt gcacagaata tttcaaactg 421 caggtatgca gacagaccag gaaggaggtt ctatgtagtt gcatgtgaca acagagatcc 481 acgggattct ccacggtatc ctgtggttcc agttcacctg gataccacca tctaagctcc 541 tgtatcagca gtcctcatca tcactcatct gccaagctcc tcaatcatag ccaagatccc 601 atccctccat gtactctggg tatcagcaac tgtcctcatc agtctccata ccccttcagc 661 tttcctgagc tgaagtccct tgtgaaccct gcaataaact gctttgcaaa ttcaaaaa 1 gaacaaccag ctggatcagt tctcacagga gccacagctc agagactggg aaacatggtt 61 ccaaaactgt tcacttccca aatttgtctg cttcttctgt tggggcttat gggtgtggag 121 ggctcactcc atgccagacc cccacagttt acgagggctc agtggtttgc catccagcac 181 atcagtctga acccccctcg atgcaccatt gcaatgcggg caattaacaa ttatcgatgg 241 cgttgcaaaa accaaaatac ttttcttcgt acaacttttg ctaatgtagt taatgtttgt 301 ggtaaccaaa gtatacgctg ccctcataac agaactctca acaattgtca tcggagtaga 361 ttccgggtgc ctttactcca ctgtgacctc ataaatccag gtgcacagaa tatttcaaac 421 tgcaggtatg cagacagacc aggaaggagg ttctatgtag ttgcatgtga caacagagat 481 ccacgggatt ctccacggta tcctgtgc ccagttcacc tggataccac catctaagct 541 cctgtatcag cagtcctcat catcactcat ctgccaagct cctcaatcat agccaagatc 601 ccatccctcc atgtactctg ggtatcagca actgtcctca tcagtctcca taccccttca 661 gctttcctga gctgaagtcc cttgtgaacc ctgcaataaa ctgctttgca aattc 1 ctgccagcag cgtatagttt tcacccagag tccagatccc accggcaaaa ctctgtctaa 61 cacaggatga cttggaatta gagtccgtat agcagaaaga gcagcagggc tgtccttggg 121 tatccgttgc tcagccaagt catcaaataa aaaggatgat tgcacaagtg gaccatgtgt 181 caatctgtgg gtttctgcat ggccagaccc accaagggaa gctttattta aacagttcca 241 agtaggggag accagctgcc cctgaacccc agaacaacca gctggatcag ttctcacagg 301 agccacagct cagagactgg gtaagtcaac aatccccaga gctgggacag gaggggcagc 361 gacagggcag cacctgaggg agaggtgagc tgaagttagt gcttaggaga tgtggcacac 421 tttggggaca ggaagaaaag gaaatgcgac cccagagtgg cagcagaggg gcctgtgggt 481 tgagacacta tagagtgtgt cataaccgag accggatagg ggagtagtta cttctcttct 541 tttcttacag gaaacatggt tccaaaactg ttcacttccc aaatttgtct gcttcttctg 601 ttggggctta tgggtgtgga gggctcactc catgccagac ccccacagtt tacgagggct 661 cagtggtttg ccatccagca catcagtctg aacccccctc gatgcaccat tgcaatgcgg 721 gcaattaaca attatcgatg gcgttgcaaa aaccaaaata cttttcttcg tacaactttt 78.1 gctaatgtag ttaatgtttg tggtaaccaa agtatacgct gccctcataa cagaactctc 841 aacaattgtc atcggagtag attccgggtg cctttactcc actgtgacct cataaatcca 901 ggtgcacaga atatttcaaa ctgcaggtat gcagacagac caggaaggag gttctatgta 961 gttgcatgtg acaacagaga tccacgggat tctccacggt atcctgtggt tccagttcac 1021 ctggatacca ccatctaagc tcctgtatca gcagtcctca tcatcactca tctgccaagc 1081 tcctcaatca tagccaagat cccatccctc catgtactct gggtatcagc aactgtcctc 1141 atcagtctcc ataccccttc agctttcctg agctgaagtc ccttgtgaac cctgcaataa 1201 actgctttgc aaattcatct ggaagtgtct gtgtgtcttc ctcggccgct ctgctgtcat 1261 ttagtgacaa tctgctctag agatttgggt ttatcatgaa tctctccccc tcaatatctg 1321 accaaattcc ttgattcccc catcatcctt catgtgatac ctgattccag gcctgcctta 1381 aaaaaaaatc caattgagtc aacttagcat tggtctccct agccttaata tctcctctaa 1441 gcaattttcc at WO 00/09525 PCT/US99/17712 EPI-109 1207 (2) INFORMATION FOR SEQ ID NO:49: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 694 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:49: 1 cacaggagct acagcgcgga gactggaaac atggttccaa aactgttcac ttcccaaatt 61 tgtctgcttc ttctgttggg gcttctggct gzggagggct cactccatgt caaacctcca 121 cagtttacct gggctcaatg gtttgaaacc cagcacatca atatgacctc ccagcaatgc 181 accaatgcaa tgcaggtcat taacaattat caacggcgat gcaaaaacca aaatactttc 241 cttcttacaa cttttgctaa cgtagttaat gtttgtggta acccaaatat gacctgtcct 301 agtaacaaaa ctcgcaaaaa ttgtcaccac agtggaagcc aggtgccttt aatccactgt 361 aacctcacaa ctccaagtcc acagaatatt tcaaactgca ggtatgcgca gacaccagca 421 aacatgttct atatagttgc atgtgacaac agagatcaac gacgagaccc tccacagtat 481 ccggtggttc cagttcacct ggatagaatc atctaagctc ctgtatcagc actcctcatc 541 atcactcatc tgccaagctc ctcaatcata gccaagatcc catctctcca tatactttgg 601 gtatcagcat ctgtcctcat cagtctccat accccttcag ctttcctgag ctgaagtgcc 661 ttgtgaaccc cgcaataaac tgctttgcaa attc (2) INFORMATION FOR SEQ ID NO:50: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1489 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:50: ctgcaggcag caatagttt tcatccagag tttggatcta accagcaaaa ctctgtctta 61 cacaggatga cttggaatta gagtccttat agcagaaaga gcagcagggc tgtccttggg 121 tatccgttgc tcagccaagt catcaaataa aaaggatgat tgcacaagtg gactatgtac 181 caatctgtgg gtttctgcat ggccaagagc cagaccctcc ctctgggctc tgctggccca 241 acccaccaag ggatgcttta tttaaacagt tccaagtagg ggagaccagc tgcccctgaa 301 ccccagaaca accagctgga tcagttctca caggagctac agcgcggaga ctgggtaagt 361 caacgatccc cagagctggg acagaagggg cagcaatggg gcagcaactg agggagaaga 421 gagctgacgt tagtgcttag gagacgttgc acactttgca gacaggaagt aaaggaaatg 481 ggaccccaga gtggccgcag aggggcctgt ggggtaagac actacagtgt gtgtcataac 541 caagacccga tcagggagta gttacttctc ttcttttctt acaggaaaca tggttccaaa. 601 actgttcact tcccaaattt gtctgcttct tctgttgggg cttctggctg tggagggctc 661 actccatgtc aaacctccac agtttacctg ggctcaatgg tttgaaaccc agcacatcaa 721 tatgacctcc cagcaatgca. ccaatgcaat gcaggtcatt aacaattatc aacggcgatg 781 caaaaaccaa. aatactttcc ttcttacaac ttttgctaac gtagttaatg tttgtggtaa. 841 cccaaatatg acctgtccta gtaacaaaac tcgcaaaaat tgtcaccaca gtggaagcca 901 ggtgccttta. atccactgta acctcacaac tccaagtcca cagaatattt caaactgcag 961 gtatgcgcag acaccagcaa acatgttcta. tatagttgca tgtgacaaca gagatcaacg 1021 acgagaccct ccacagtatc cggtggttcc agttcacctg gatagaatca tctaagctcc 1081 tgtatcagca ctcctcatca tcactcatct gccaagctcc tcaatcatag ccaagatccc 1141 atctctccat atactttggg tatcagcatc tgtcctcatc agtctccata ccccttcagc 1201 tttcctgagc tgaagtgcct tgtgaaccct gcaataaact gctttgcaaa ttcatctgaa 1261 agtgtctgtg tgtcttcatt agccgctctg ctgtcattta gtgacaatct actctagaga 1321 tttttcttcc tctaacctga gacttccggg aaacagagag atttgaagat aagagacgct 1381 ttctgtcatg aaacagcaca gtcttatccc tctccctgct ttaggctgag aagctgaggt 1441 ctcaaccgat atctagcaac tgtcgaagac tcttgctttg atcaagctt (2) INFORMATION FOR SEQ ID NO:51: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 735 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:51: 1 gctgcccctg aaccccagaa caaccagctg gatcagttct cacaggagct acaggccgga 61 gactgggaaa catggttcca aaactgttca cttcccaaat ttgtctgctt cttctgttgg 121 ggcttctggc tgtggagggc tcactccatg tcaaacctcc acagtttacc tgggctcaat 181 ggtttgaaac ccagcacatc aatatgacct cccagcaatg caccaatgca atgcaggtca 241 ttaacaatta tcaacggcga tgcaaaaacc aaaatacttt ccttcttaca acttttgcta 301 acgtagttaa tgtttgtggt aacccaaata tgacctgtcc tagtaacaaa actcgcaaaa 361 attgtcacca cagtggaagc caggtgcctt taatccactg taacctcaca actccaagtc 421 cacagaatat ttcaaactgc aggtatgcgc agacaccagc aaacatgttc tatatagttg 481 cacgtgacaa cagagatcaa cgacgagacc ctccacagta tccggtggtt ccagttcacc 541 tggatagaat catctaagct cctgtatcag cactcctcat catcactcat ctgccaagct 601 cctcaatcat agccaagatc ccatctctcc atatactttg ggtatcagca tctgtcctca 661 tcagtctcca aaccccttca gctttcctga gctgaagtgc cttgtgaacc ctgcaataaa 721 ctgctttgca aattc WO 00/09525 PCT/US99/17712 EPI-109 1208 (2) INFORMATION FOR SEQ ID NO:52: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 2918 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:52: 1 cacaggagct acagcgcgga gactggaaac atggttccaa aactgttcac ttcccaaatt 61 tgtctgcttc ttctgttggg gcttctggct gtggagggct cactccatgt caaacctcca 121 cagtttacct gggctcaatg gtttgaaacc cagcacatca atatgacctc ccagcaatgc 181 accaatgcaa tgcaggtcat taacaattat caacggcgat gcaaaaacca aaatactttc 241 cttcttacaa cttttgctaa cgtagttaat gtttgtggta acccaaatat gacctgtcct 301 agtaacaaaa ctcgcaaaaa ttgtcaccac agtggaagcc aggtgccttt aatccactgt 361 aacctcacaa ctccaagtcc acagaatatt tcaaactgca ggtatgcgca gacaccagca 421 aacatgttct atatagttgc atgtgacaac agagatcaac gacgagaccc tccacagtat 481 ccggtggttc cagttcacct ggatagaatc atctaagctc ctgtatcagc actcctcatc 541 atcactcatc tgccaagctc ctcaatcata gccaagatcc catctctcca tatactttgg 601 gtatcagcat ctgtcctcat cagtctccat accccttcag ctttcctgag ctgaagtgcc 661 ttgtgaaccc tgcaataaac tgctttgcaa attc 1 ctgcaggcag catatagttt tcatccagag tttggatcta accagcaaaa ctctgtctta 61 cacaggatga cttggaatta gagtccttat agcagaaaga gcagcagggc tgtccttggg 121 tatccgttgc tcagccaagt catcaaataa aaaggatgat tgcacaagtg gactatgtac 181 caatctgtgg gtttctgcat ggccaagagc cagaccctcc ctctgggctc tgctggccca 241 acccaccaag ggatgcttta tttaaacagt tccaagtagg ggagaccagc tgcccctgaa 301 ccccagaaca accagctgga tcagttctca caggagctac agcgcggaga ctgggtaagt 361 caacgatccc cagagctggg acagaagggg cagcaacggg gcagcaactg agggagaaga 421 gagctgacgt tagtgcttag gagacgttgc acactttgca gacaggaagt aaaggaaatg 481 ggaccccaga gtggccgcag aggggcctgt ggggtaagac actacagtgt gtgtcataac 541 caagacccga tcagggagta gttacttctc ttcttttctt acaggaaaca tggttccaaa 601 actgttcact tcccaaattt gtctgcttct tctgttgggg cttctggctg tggagggctc 661 actccatgtc aaacctccac agtttacctg ggctcaatgg tttgaaaccc agcacatcaa 721 tatgacctcc cagcaatgca ccaatgcaat gcaggtcatt aacaattatc aacggcgatg 781 caaaaaccaa aatactttcc ttcttacaac ttttgctaac gtagttaatg tttgtggtaa 841 cccaaatatg acctgtccta gtaacaaaac tcgcaaaaat tgtcaccaca gtggaagcca 901 ggtgccttta atccactgta acctcacaac tccaagtcca cagaatattt caaactgcag 961 gtatgcgcag acaccagcaa acatgttcta tatagttgca tgtgacaaca gagatcaacg 1021 acgagaccct ccacagtatc cggtggttcc agttcacctg gatagaatca tctaagctcc 1081 tgtatcagca ctcctcatca tcactcatct gccaagctcc tcaatcatag ccaagatccc 1141 atctctccat atactttggg tatcagcatc tgtcctcatc agtctccata ccccttcagc 1201 tttcctgagc tgaagtgcct tgtgaaccct gcaataaact gctttgcaaa ttcatctgaa 1261 agtgtctgtg tgtcttcatt agccgctctg ctgtcattta gtgacaatct actctagaga 1321 tttttcttcc tctaacctga gacttccggg aaacagagag atttgaagat aagagacgct 1381 ttctgtcatg aaacagcaca gtcatatccc tctccctgct ttaggctgag aagctgaggt 1441 ctcaaccgat atctagcaac tggcgaagac tcttgctttg atcaagctt 1 gctgcccctg aaccccagaa caaccagctg gatcagttct cacaggagct acaggccgga 61 gactgggaaa catggttcca aaactgttca cctcccaaat ttgtctgctt cttctgttgg 121 ggcttctggc tgtggagggc tcactccatg tcaaacctcc acagtttacc tgggctcaat 181 ggtttgaaac ccagcacatc aatatgacct cccagcaatg caccaatgca atgcaggtca 241 ttaacaatta tcaacggcga tgcaaaaacc aaaatacttt ccttcttaca acttttgcta 301 acgtagttaat tgtttgtggt aacccaaata tgacctgtcc tagtaacaaa actcgcaaaa 361 attgtcacca cagtggaagc caggtgcctt taatccactg taacctcaca actccaagtc 421 cacagaatat ttcaaactgc aggtatgcgc agacaccagc aaacatgttc tatatagttg 481 catgtgacaa cagagatcaa cgacgagacc ctccacagta tccggtggtt ccagttcacc 541 tggatagaat catctaagct cctgtatcag cactcctcat catcactcat ctgccaagct 601 cctcaatcat agccaagatc ccatctctcc atatactttg ggtatcagca tctgtcctca 661 tcagtctcca taccccttca gctttcctga gctgaagtgc cttgtgaacc ctgcaataaa 721 ctgctttgca aattc (2) INFORMATION FOR SEQ ID NO:53: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 391 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:53: 1 ccatggagga aggtcaatat tcaggtagga ggactctctg gttctaacgt tggcagaagc 61 aatgaccctt agctactcct ttcacccaga agagaatcgg ggcttcccag tccctctctg 121 ggaaagaggg tgaatttcta agaaagggac tggtgtgagt aaggaggga ggccgcactg 181 actttcctgg cacagagcca ggaaggagtg gaaaattgag ggcccctcct ttttctgatt 241 caacaccctc ctgacaaaaa aagaaaaaga aaaaaaaaaa cggcttcagc tagggagcgg WO 00/09525 PCT/US99/17712 EPI-109 1209 301 ggacgcaaza gagtcagagg ccaaatagaa caggaacttg gaacaagcag aatttagcat 361 aargaatcoz ccaagccagg gtgagtgcag a (2) INFORMATION FOR SEQ ID NO:54: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 3108 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:54: 1 aagcttggga ataagtccag ctgggccatg ttgtgaggac atggggatga agtcttagtt 61 ccaggatggg gctgggatgg agtttggtgt ttcttttctg tttttctttc ttttttcttt 121 tctttttttt ttttgtgaga cagagtttag cttttgttgc ccaggctgga atgcaatggc 181 ggatctcggc tcaccgcaac ctctgcctcc cggattcaag cgattctcct gcctcagcct 241 cccgagtaac taggattaca ggtgcccacc accatgccca gctaattttt tttttttttt 301 tttttttttg tattttcagt agatacaggg tttcaccatg ttggccttga actcctgacc 361 tcagatgatc cacctgcctc ggcctcccaa agtgctggga ttacaggcgc tgacgatgtg 421 cccggtctct ctctctctct ttctctctct ctttctttca tctcactgtg ttgccccagg 481 ctgatcttga actcctgggc tcaagtgatc cactcacctc tgcctcccca gtagctggga 542. tcacaggcat gcaccaccat gccctgctag tttttatagt ttttgtagag acaacggctt 601 gctatgttgt ccaggctggt cttgaactcc caggcttaag tgatcctccc acctcagcct 661 cccaaagtgc tgggattaca ggcgtgaacg tccgtgccag ccaaactgtc catatttgac 721 ctgaatatta tctcacgtat ctttctttcc ccccgcttcc ctccttccct cctactcctc 781 cttctccctc tccttccttc tgtctttttt ttccccttcc tctgcctctc tctcctcttc 841 ccttttttct tgctgggact caaacctggg acatttgacc tgggagccta tttgctcaat 901 catcagaga cataatctca tggtggggtg tctgctggta agtgccgggt ggcaggatcc 961 caactccagg ccgtccttct aacccaagag gccctgcctc tgcctagagc cttccgtggc 1021 tccccagggc cctctgtgat cggccatagt ggtatgattc agtgtgcagt aacagtggtt 1081 cacatcttga cgctaccact cacctccttc agccctgtgg gaacttgctg cttaacetct 1141 ctagttctca cccaattctc ttacctgaga aatggagata ataataacac ggacttcacc 1201 cgggtgtggg gagcaccagg agaggccatg cgtgtaatgt tatccgggtg gcaagcccat 1261 atttaggtct atgaaaatag aagctgtcag tggctctact ttcagaagaa agtgtctctc 1321 ttcctgctta aacctctgtc tctgacggtc cctgccaatc gctctggtcg accccaacac 1381 actaggagga cagacacagg ctccaaactc cactaagtga gtacgtatct ggtgtgttgg 1441 gggttggccc atgggcagtg gagatcaaag cgcccttgga agaaacgacc ttgggctgag 1501 cctcaaggga tgaccagcag gaggtcacaa ccagagaagg gaggtggtgg gtggtgaggg 1561 ggcgggggtg ggggccgcag tgtggacaga atctcgaggc attcgagtcc ctgatttggg 1621 gaagtgaaag caggccatct ggtctgagat gagcttggtg agtgcgctgg gccgatcata 1681 gagggccctg gggagccatg gaagactcta ggcagaggca ggacctcttg ggttagaagg 1741 acggcctgga gttgggatcc tgccacccag cacttaccag tagacacccc accatgagat 1801 tatgtctcca gatgattgag caaatgggct cccagctcaa gggtcccggg tttgagtcca 1861 gtcccaccac tgcgtgatgg ggacaaatga cttaccctct tggaacctca gttccactga 1921 gagaggcccc acagaatgag gacagtcccc cagcatcctg ccagtaggtt tactgagcac 1981 ctactgtgtg ctggtgcttt gaatactccc aatttacaga tgagcaaact gagctgctca 2041 tccagggaga agccaggact cggactcagg tctgtccagc tgcctccctg gacagttcca 2101 gtcccaggat ggtctctggg ttcctctcac aatgtcaaaa gggccagctt gagctgccgc 2161 taatcagagc ctggccgcgc cacaccccac ctccctgagg ctccgagaga agggacttac 2221 ctatagtcaa gcagcgaaag aaggtagccc gtgacctcca ggcctgaagg accccaagtc 2281 ccatgctcct cagcacatag tagatgcttt aaagtcagag gacttggtcg ggcgcaggca 2341 cgcctgtaat cctagcactt tgggaggctg aggagggcag atcacctgtg gtcaggagtt 2401 cgagaccagc ctgatcaata tggtgaaacc ctgtctctac taaaatacaa aaattagcca 2461 ggtgtggtgg tgggtgcctg tagtcccagc tacttgggag gctaagacag gagaatcgct 2521 tgaacccggg aggtggaggt tgcagtgagc caagatggtg ccattgcact ctagcctggg 2581 tgacagagcg agactccatc tcaaaaaata aaaaaatagg ccatgcacag gctcacgcct 2641 gtaatcccag cactttggga ggccgaggcg ggcggatcat gaggtcagga gtttgagact 2701 agcctggcca acatagtgaa aacccgtctc tactaaaaat acaaaaatta tctggtcatg 2761 gtggcacgtg actatagtcc cagctactcg ggaggctgag gcgggagaat cgcttgaacc 2821 caggaggtgg aggtggcagt gagccgagat cgtgcccctg cactccagcc tgggcaacag 2881 agcgagactc catttcaata aataaataaa taaataaagt cagagcactt tacagatgcc 2941 ctggggacat tggcagagga gaaggctgag gcctgggtta tgggctctta gcatttctca 3001 gtgggacgtg gcacagagta gatgtttcat aaatgtttag aatctgaaga cccactgtgc 3061 gcagcccggc accaaaaacc tcaggtatgc tgtgatctca ttggatcc (2) INFORMATION FOR SEQ ID NO:55: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1503 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:55: 1 ctcctgctta aacctctgtc tctgacggtc cctgccaatc gctctggtcg accccaacac 61 actaggagga cagacacagg ctccaaactc cactaagtga ccagagctgt gattgtgccc 121 gctgagtgga ctgcgttgtc agggagtgag tgctccatca tcgggagaat ccaagcagga 181 ccgccataga ggaaggtcaa tattcagaga tcgaggagct tcccaggagg cggtgttgca 241 ggcgtgggac tcagatcgtg ctgctggggc tggtgaccgc cgctctgtgg gctgggctgc WO 00/09525 PCT/US99/17712 EPI-109 1210 301 tga ctctg-z tctcctatgg cactgggaca ccacacagag tctaaaacag ctggaagaga 361 gggczacccg gaacgtctct caagtttcca agaacttgga aagccaccac ggcgaccaga 421 tggcgcagaa atcccagccc acgcagatt cacaggaact ggaggaactt cgagctgaac 481 agcagagatt gaaatctcag gacttggagc t.gtcctggaa cctgaacggg cttcaagcag 541 atctgagcag cttcaagtcc caggaattga acgagaggaa cgaagcttca gatttgctgg 601 aaagactccg ggaggaggtg acaaagctaa ggatggagtt gcaggtgtcc agcggctttg 661 tgtgcaacac gtgccctuaa aagtggatca atttccaacg gaagtgctac tacttcggca 721 agggcaccaa gcagtgggtc cacgcccggt atgcctgtga cgacatggaa gggcagctgg 781 tcagcatcca cagcccggag gagcaggact tcctgaccaa gcatgccagc cacaccggct 841 cctggattgg ccttcggaac ttggacctga agggagagtt tatctgggtg gatgggagcc 901 atgtggacta cagcaactgg gctccagggg agcccaccag ccggagccag ggcgaggact 961 gcgtgatgat gcggggctcc ggtcgctgga acgacgcctt ctgcgaccgt aagctgggcg 1021 cctgggtgtg cgaccggctg gccacatgca cgccgccagc cagcgaaggt tccgcggagt 1081 ccatgggacc tgattcaaga ccagaccctg acggccgcct gcccaccccc tctgcccctc 1141 tccactcttg agcatggata cagccaggcc cagagcaaga ccctgaagac ccccaaccac 1201 ggcctaaaag cctctttgtg gctgaaaggt ccctgtgaca ttttctgcca cccaaacgga 1261 ggcagctgac acatctcccg ctcctctatg gcccctgcct tcccaggagt acaccccaac 1321 agcaccctct ccagatggga gtgcccccaa cagcaccctc tccagatgag agtacacccc 1381 aacagcaccc tctccagatg cagccccatc tcctcagcac cccaggacct gagtatcccc 1441 agctcaggtg gtgagtcctc ctgtccagcc tgcatcaata aaatggggca gtgatggcct 1501 ccc (2) INFORMATION FOR SEQ ID NO:56: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1530 base pairs (B) TYPE: nucleic acid (C) STRAI4DEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:56: 1 agtggctcta ctttcagaag aaagtgtctc tcttcctgct taaacctctg tctctgacgg 61 tccctgccaa tcgctctggt cgaccccaac acactaggag gacagacaca ggctccaaac 121 tccactaacc agagctgtga ttgtgcccgc tgagtggact gcgttgtcag ggagtgagtg 181 ctccatcatc gggagaatcc aagcaggacc gccatggagg aaggtcaata ttcagagatc 241 gaggagcttc ccaggaggcg gtgttgcagg cgtgggactc agatcgtgct gctggggctg 301 gtgaccgccg ctctgtgggc tgggctgctg actctgcttc tcctgtggca ctgggacacc 361 acacagagtc taaaacagct ggaagagagg gctgcccgga acgtctctca agtttccaag 421 aacttggaaa gccaccacgg tgaccagatg gcgcagaaat cccagtccac gcagatttca 481 caggaactgg aggaacttcg agctgaacag cagagattga aatctcagga cttggagctg 541 tcctggaacc tgaacgggct tcaagcagat ctgagcagct tcaagtccca ggaattgaac 601 gagaggaacg aagcttcaga tttgctggaa aqactccggg aggaggtgac aaagctaagg 661 atggagttgc aggtgtccag cggctttgtg tgcaacacgt gccctgaaaa gtggatcaat 721 ttccaacgga agtgctacta cttcggcaag ggcaccaagc agtgggtcca cgcccggtat 781 gcctgtgacg acatggaagg gcagctggtc agcatccaca gcccggagga gcaggacttc 841 ctgaccaagc atgccagcca caccggctcc tggattggcc ttcggaactt ggacctgaag 901 ggagagttta tctgggtgga tgggagccat gtggactaca gcaactgggc tccaggggag 961 cccaccagcc ggagccaggg cgaggactgc gtgatgatgc ggggctccgg tcgctggaac 1021 gacgccttct gcgaccgtaa gctgggcgcc tgggtgtgcg accggctggc cacatgcacg 1081 ccgccagcca gcgaaggttc cgcggagtcc atgggacctg attcaagacc agaccctgac 1141 ggccgcctgc ccaccccctc tgcccctctc cactcttgag catggataca gccaggccca 1201 gagcaagacc ctgaagaccc ccaaccacgg cctaaaagcc tctttgtggc tgaaaggtcc 1261 ctgtgacatt ttctgccacc caaacggagg cagctgacac atctcccgct cctctatggc 1321 ccctgccttc ccaggagtac accccaacag caccctctcc agatgggagt gcccccaaca 1381 gcaccctctc cagatgagag tacaccccaa cagcaccctc tccagatgca gccccatctc 1441 ctcagcaccc caggacctga gtatccccag ctcaggtggt gagtcctcct gtccagcctg 1501 catcaataaa atggggcagt gatggcctcc (2) INFORMATION FOR SEQ ID NO:57: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 5533 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:57: l ccatggagga aggtcaatat tcaggtagga ggactctctg gttctaacgt tggcagaagc 61 aatgaccctt agctactcct ttcacccaga agagaagcgg ggcttcccag tccctctctg 121 ggaaagaggg tgaatttcta agaaagggac tggtgtgagt aaggaggtga ggccgcactg 181 actttcccgg cacagagcca ggaaggagtg gaaaattgag ggcccctcct ttttctgatt 241 caacaccctc ctgacaaaaa aagaaaaaga aaaaaaaaaa cggcttcagc tagggagcgg 301 ggacgcaata gagtcagagg ccaaatagaa caggaacttg gaacaagcag aatttagcat 361 aatgaatcct ccaagccagg gtgagtgcag a 1aagcttggga ataagtccag ctgggccatg ttgtgaggac atggggatga agtcttagtt 61 ccaggatggg gctgggatgg agtttggtgt ttcttttctg tttttctttc ttttttcttt 121 tctttttttt ttttgtgaga cagagtttag cttttgttgc ccaggctgga atgcaatggc 181 ggatctcggc tcaccgcaac ctctgcctcc cggattcaag cgattctcct gcctcagcct 241 cccgagtagc taggattaca ggtgcccacc accatgccca gctaattttt tttttttttt WO 00/09525 PCT/US99/17712 EPI-109 1211 301 tttttttttg tattttcaar agatacaggg :t:accacg ttggccttga actcctgacc 361 tcagatgatc cacctacczc agcctcccaa aazgctggga ttacaggcgc tgacgatgtg 421 cccggtctct ctctctctct z.tctctctct c=ttctttca tctcactgtg ttgccccagg 481 ctgatcttga actcctgggc tcaagtgatc cactcacctc tgcctcccca gtagctggga 541 tcacaggcat gcaccaccat gccctgctag tttatagt ttttgtagag acaacggctt 601 gctatgttgt ccaggctggt cttgaactcc caggcttaag tgatcctccc acctcagcct 661 cccaaagtgc tgggattaca ggcgtgaacg tccgtgccag ccaaactgtc catatttgac 721 ctgaatatta tctcacgtat ctttctttcc ccccgcttcc ctccttccct cctactcctc 781 cttctccctc tccttccttc tgtctttttt ttccccttcc tctgcctctc tctcctcttc 841 ccttttttct tgctgggact caaacctggg acatttgacc tgggagccta tttgctcaat 901 catcaagaga cataatctca tggtggggcg tctgctggta agtgccgggt ggcaggatcc 961 caactccagg ccgtccttct aacccaagag gccctgcctc tgcctagagc cttccgtggc 1021 tccccagggc cctctgtgat cggccatagt ggtatgattc agtgtgcagt aacagtggtt 1081 cacatcttga cgctaccact cacctccttc agccctgtgg gaacttgctg cttaacatct 1141 ctagttctca cccaattctc ttacctgaga aatggagata ataataacac ggacttcacc 1201 cgggtgtggg gagcaccagg agaggccatg cgtgtaatgt tatccgggtg gcaagcccat 1261 atttaggtct atgaaaatag aagctgtcag tggctctact ttcagaagaa agtgtctctc 1321 ttcctgctta aacctctgtc tctgacggtc cctgccaatc gctctggtcg accccaacac 1381 actaggagga cagacacagg ctccaaactc cactaagtga gtacgtatct ggtgtgttgg 1441 gggttggccc atgggcagtg gagatcaaag cgcccttgga agaaacgacc ttgggctgag 1501 cctcaaggga tgaccagcag gaggtcacaa ccagagaagg gaggtggtgg gtggtgaggg 1561 ggcgggggtg ggggccgcag tgtggacaga atctcgaggc attcgagtcc ctgatttggg 1621 gaagtgaaag caggccatct ggtctgagat gagcttggtg agtgcgctgg gccgatcata 1681 gagggccctg gggagccatg gaagactcta ggcagaggca ggacctcttg ggttagaagg 1741 acggcctgga gttgggatcc tgccacccag cacttaccag tagacacccc accatgagat 1801 tatgtctcca gatgattgag caaatgggct cccagctcaa gggtcccggg tttgagtcca 1861 gtcccaccac tgcgtgatgg ggacaaatga cttaccctct tggaacctca gttccactga 1921 gagaggcccc acagaatgag gacagtcccc cagcatcctg ccagtaggtt tactgagcac 1981 ctactgtgtg ctggtgcttt gaatactccc aatttacaga tgagcaaact gagctgctca 2041 tccagggaga agccaggact cggactcagg tctgtccagc tgcctccctg gacagttcca 2101 gtcccaggat ggtctctggg ttcctctcac aatgtcaaaa gggccagctt gagctgccgc 2161 taatcagagc ctggccgcgc cacaccccac ctccctgagg ctccgagaga agggacttac 2221 ctatagtcaa gcagcgaaag aaggtagccc gtgacctcca ggcctgaagg accccaagtc 2281 ccatgctcct cagcacatag tagatgcttt aaagtcagag gacttggtcg ggcgcaggca 2341 cgcctgtaat cctagcactt tgggaggctg aggagggcag atcacctgtg gtcaggagtt 2401 cgagaccagc ctgatcaata tggtgaaacc ctgtctctac taaaatacaa aaattagcca 2461 ggtgtggtgg tgggtgcctg tagtcccagc tacttgggag gctaagacag gagaatcgct 2521 tgaacccggg aggtggaggt tgcagtgagc caagatggtg ccattgcact ctagcctggg 2581 tgacagagcg agactccatc tcaaaaaata aaaaaatagg ccatgcacag gctcacgcct 2641 gtaatcccag cactttggga ggccgaggcg ggcggatcat gaggtcagga gtttgagact 2701 agcctggcca acatagtgaa aacccgtctc tactaaaaat acaaaaatta tctggtcatg 2761 gtggcacgtg actatagtcc cagctactcg ggaggctgag gcgggagaat cgcttgaacc 2821 caggaggtgg aggtggcagt gagccgagat cgtgcccctg cactccagcc tgggcaacag 2881 agcgagactc catttcaata aataaataaa taaataaagt cagagcactt tacagatgcc 2941 ctggggacat tggcagagga gaaggctgag gcctgggtta tgggctctta gcatttctca 3001 gtgggacgtg gcacagagta gatgtttcai aaatgtttag aatctgaaga cccactgtgc 3061 gcagcccggc accaaaaacc tcaggtatgc tgtgatctca ttggatcc 1 ctcctgctta aacctctgtc tctgacggtc cctgccaatc gctctggtcg accccaacac 61 actaggagga cagacacagg ctccaaactc cactaagtga ccagagctgt gattgtgccc 121 gctgagtgga ctgcgttgtc agggagtgag tgctccatca tcgggagaat ccaagcagga 181 ccgccatgga ggaaggtcaa tattcagaga tcgaggagct tcccaggagg cggtgttgca 241 ggcgtgggac tcagatcgtg ctgctggggc tggtgaccgc cgctctgtgg gctgggctgc 301 tgactctgct tctcctgtgg cactgggaca ccacacagag tctaaaacag ctggaagaga 361 gggctgcccg gaacgtctct caagtttcca agaacttgga aagccaccac ggtgaccaga 421 tggcgcagaa atcccagtcc acgcagattt cacaggaact ggaggaactt cgagctgaac 481 agcagagatt gaaatctcag gacttggagc tgtcctggaa cctgaacggg cttcaagcag 541 atctgagcag cttcaagtcc caggaattga acgagaggaa cgaagcttca gatttgctgg 601 aaagactccg ggaggaggtg acaaagctaa ggatggagtt gcaggtgtcc agcggctttg 661 tgtgcaacac gtgccctgaa aagtggatca atttccaacg gaagtgctac tacttcggca 721 agggcaccaa gcagtgggtc cacgcccggt atgcctgtga cgacatggaa gggcagctgg 781 tcagcatcca cagcccggag gagcaggact tcctgaccaa gcatgccagc cacaccggct 841 cctggattgg ccttcggaac ttggacctga agggagagtt tatctgggtg gatgggagcc 901 atgtggacta cagcaactgg gctccagggg agcccaccag ccggagccag ggcgaggact 961 gcgtgatgat gcggggctcc ggtcgctgga acgacgcctt ctgcgaccgt aagctgggcg 1021 cctgggtgtg cgaccggctg gccacatgca cgccgccagc cagcgaaggt tccgcggagt 1081 ccatgggacc tgattcaaga ccagaccctg acggccgcct gcccaccccc tctgcccctc 1141 tccactcttg agcatggata cagccaggcc cagagcaaga ccctgaagac ccccaaccac 1201 ggcctaaaag cctctttgtg gctgaaaggt ccctgtgaca ttttctgcca cccaaacgga 1261 ggcagctgac acatctcccg ctcctctatg gcccctgcct tcccaggagt acaccccaac 1321 agcaccctct ccagatggga gtgcccccaa cagcaccctc tccagatgag agtacacccc 1381 aacagcaccc tctccagatg cagccccatc tcctcagcac cccaggacct gagtatcccc 1441 agctcaggtg gtgagtcccc ctgtccagcc tgcatcaata aaatggggca gtgatggcct 1501 ccc 1 agtggctcta ctttcagaag aaagtgcctc tcttcctgct taaacctctg tctctgacgg 61 tccctgccaa tcgctctggt cgaccccaac acactaggag gacagacaca ggctccaaac WO 00/09525 PCT/US99/17712 EPI-109 1212 121 tccactaacc agagccatga ttatgcccgc tgagtggact gcaztatcag ggagtgagtc 181 ctccatcatc gggagaarcc aagcaggacc gccatggagg aacatcaata ttcagagazc 241 gaggagc--tc ccaggaggcg gtgttgcagg cgtgggactc agarcgtgct gctggggctg 301 gtgaccgccg ctctgtgggc tgggctgctg actctgcttc tcctgtggca ctgggacacc 361 acacagagtc taaaacagct ggaagagagg gctgcccgga acgrctctca agtttccaag 421 aacttggaaa gccaccacgg tgaccagatg gcgcagaaac cccagtccac gcagatttca 481 caggaactgg aggaacttcg agctgaacag cagagattga aatctcagga cttggagctg 541 tcctggaacc tgaacgggct tcaagcagat ctgagcagct tcaagtccca ggaattgaac 601 gagaggaacg aagcttcaga tttgctggaa agactccggg aggaggtgac aaagctaagg 661 atggagttgc aggtgtccag cggctttgtg tgcaacacgt gccctaaaaa gtggatcaat 721 ttccaacgga agtgctacta cttcggcaag ggcaccaagc agtgggtcca cgcccggtat 781 gcctgtgacg acatggaagg gcagctggtc agcatccaca gcccggagga gcaggacttc 841 ctgaccaagc atgccagcca caccggctcc tggattggcc ttcggaactt ggacctgaag 901 ggagagttta tctgggtgga tgggagccat gtggactaca gcaactgggc tccaggggag 961 cccaccaacc ggagccaggg cgaggactgc gtgatgatgc ggggctccgg tcgctggaac 1021 gacgccttct gcgaccgtaa gctgggcgcc tgggtgtgcg accggctggc cacatgcacg 1081 ccgccagcca gcgaaggttc cgcggagtcc atgggacctg attcaagacc agaccctgac 1141 ggccgcctgc ccaccccctc tgcccctctc cactcttgag catggataca gccaggccca 1201 gagcaagacc ctgaagaccc ccaaccacgg cctaaaagcc tctttgtggc tgaaaggtcc 1261 ctgtgacatt ttctgccacc caaacggagg cagctgacac atctcccgct cctctatggc 1321 ccctgccttc ccaggagtac accccaacag caccctctcc agatgggagt gcccccaaca 1381 gcaccctctc cagatgagag tacaccccaa cagcaccctc tccagatgca gccccatctc 1441 ctcagcaccc caggacctga gtatccccag ctcaggtggt gagtcctcct gtccagcctg 1501 catcaataaa atggggcagt gatggcctcc (2) INFORMATION FOR SEQ ID NO:58: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 825 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:58: 1 gtaagtatct tccctctgtg gctaggaaga caaggaatac atttttaaat gtctcctaaa 61 gcaaggacct gaaaccagct ctatgggatt attcttgttc ctctttggtc aatgcagaga 121 catgggaaga accaccaaaq gtcatgaggg tctcttccag ggatccctgg acattgcctt 181 tcccagtggt gtgacaagag ttagaggtgg cctaccttgc ctcctgtcct aggaggcgac 241 agtaggagag ccttcggttt tctcatcctc ttacttgtat gttgaacttt acttaatgca 301 ggctatatcc aaaatacagt gtgaattagg ctagaataga aatgctttct attctacctt 361 cagaaaagga aaagggtagg gtaggggaaa tcatgggaga gattaaaggc agagaggaaa 421 cccagatagg actgtttaat ccccaagcaa gaaaccacta ggaaagagag ataccttccc 481 tctaactttt gtattcggtg cactgacatt gctctctgtg ctggtgggaa attgatttct 541 gtgccaggat gttctaggct gaggccaaga gggtgctggc cctttaccca gtggaagaaa 601 aaggcaaggg tgaggctttg tagactttcc cattcggagg taatgatgcc tccttcagcc 661 ccacttcttc aaactgactc cacctgctcc catctccaca cccctccgtt tctcatttag 721 ccaaagcaca tcatccttgc agcccaccac tcagcttggc caggtgcgag acatctttcc 781 ccacttcata cctcccctcc ggccaggtga tgtttgcctc ctcag (2) INFORMATION FOR SEQ ID NO:59: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 32351 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:59: 1 gatcacctga agtcaggagt tcgagaccag cctgaccaac atggagaaac cccgtctcta 61 ctaaaaatac aaaattagtt gggcatggtc gtgcatgcct gtaatcccag ctactcagga 121 ggctgaggca ggagtatcac ttgaacccag gagacggagg ttgcggtgag ccaagaacat 181 gccattgcac tccagccttg gcaacaagag caaaactccg tctcaaagaa aaaaaaaatt 241 tttttttgtc aacccatgtg ggtatgaaat tgtttctcat tatttgcatt tcactaatta 301 ctagtgaggt caaacatttt ttccctcatt tcttatccat taaagtttat tctgtgaatt 361 gccagttcat ggccattttg ggggtgtagt ttttcttact gatttattga agtttaatgt 421 ttttctggaa actaatattt tgctagttgt gtgaattgta aatatcttct cccactgtat 481 ttttttaaaa actttttatt gtctgaatta gcacatattt agtgaatgcc tctatgtgca 541 attctttttt tttttttttt tttttttttg agatggagtt tcgctcttgt ttcccagact 601 ggagtgcagt ggcatgatct aagctcactg caaccttcac ctcccgggtt caagtgattc 661 tcctgcctca ggcctcctga gtagctggga ttacaggtgc ccgctaccat gaccagctaa 721 ttttttgtat ttttagtaga gacggggttt catcatgttg gccaggttgg tctcgaactc 781 ctgacctcag gtgatccacc cgcctcggcc ttccaaagtg tagggattac aggcatgagc 841 cagtgagctc agcctctatg tgcaattctt aatgtcaagc tgagggagaa gtctaagaag 901 ttttatataa gtctgacacc cagggtgcct gtaattaaag gtggaatgaa attttaattt 961 gcgagttgat ccttctgttt tttagttcag tacttcctcc tttttagaat gtatgctttc 1021 cagataatta gtgagataaa gatttgattt tcacttttag catttctaaa agctgtaata 1081 tgctacctaa cttgttttta attcttgctc taacttctga tattttatag ttgtgtattt 1141 tgaattatat tttaaaggat taagtggatt attgcacatg atatttagta aagtgtttgg 1201 gagcatttag cacagcctcc aaaaattaga attccactag ccccctgatc ctacatatct WO 00/09525 PCT/US99/17712 EPI-109 1213 1261 ggcazct~aa aagtcaataa tagcaaagtt gagagaggca gcttggtg gtggaaagaa 1321 cat:ggtart ggatccgata gccttaggtt caaatcctgg cttcttzagz aattatcttc 1381 tgtaatttta accaagtgtt taatttcctt gagactcagt ttctcgaaga tgaagtagaa 1441 aatggctttc accaggttgt tgtaaagact gaatcaaata gtgtgCatga aaattgcaag 1501 gcatagtgct caggacatag ttaacattct taaatatatg ttgaggaarg gtgtgcacct 1561 gaaaattcct ataaaagctg caaatataca tgccttttga tccagctgtt ccacttcagg 1621 atatccttac tcatgtgtgc aaagcaattt tttgtagaaa tgtttataat agCaaaagac 1681 tgaaaacaac taaaatgtac actgctaggg aactgattac tctctggzat gtccacgcaa 1741 tgcagctcta taaaaaaaag gagtacgtgt caagatatat taacaaataa agtacagaat 1801 attatactgt acttatccct tttgtgttta acaaaagaaa gaaaaagaga aaaattagaa 1861 tatagtatat atttgccttt atgtgcaaaa aaaggaaatc actttttgtt ttttttgaga 1921 cagggtctca ttctgtcacc caggctgggg tgcagtggcg ctatcacggc tcactgcaac 1981 ctcaacctcc caggctcaag cgatcctccc gccacagcct cccaagtagc tgggactaca 2041 ggcacacgcg ccatgcccag ctaatttatt tatttatttt tggtagagat ggggtttcgc 2101 gatgttaccc aggctggtct caaactcctg agttcaggtg atccacctgt cttggcctcc 2161 caaagtgctc tgggattaca ggcatgagcc actgtgcctg acctcttttc ttcttgatgt 2221 gaaattcttc atagattaga caaatttgcc cattgtgcaa atatgttgCa aatatatttt 2281 ctcagtttgt catttatctt gatttttctt atggttttaa aaaaatatga ttggatttat 2341 ggtttctggc attgaaccat agttataaat gtattcttta ctctgaggtt gtccagggaa 2401 tcttctaatt ttcttaattt aattttcatc ttttaaaaac agctctattg atgcataatt 2461 gatatacaaa aatagcatat atttactact atttgatgag tttggacatg tgtacacacc 2521 catgaagcca tcagttaacc tgatggtggt gatggtttcc tgtaatttta tgcttccatt 2581 tttcacattt agatctgact tttctggaat ttatctaagt gcacgatgtg aaagatagat 2641 acagcttatt tttctttcca gatggctata ccttgttcta ggacaattta ttaaatagtc 2701 catctttttc tttctgatct gagatgctat ctttattata tgctaaattt ctgtacatgt 2761 ttaaatttat ttgctccttt tgtttgtctc tttgtacacc agtatctacc tcattgttct 2821 aattattcga gcttcaggat acattttaat acttctgggt aggaacaaaa ccttctcgtt 2881 actcttacaa aattttcttc tttattctgg tttatttttc ctaagaactz taaaagttgg 2941 cactgaattc caaaatagaa cacccaaaaa cctgttgatt tttccactgg gattatgtta 3001 aattttcggg ttaacttagg ggaaaaccat tatttcatga tgttaaatct tactccatga 3061 gagagcatgg tacgtctttt catctgtaca ggtctttttt tatattgttc agtagcaatt 3121 taaaaaaatc atccactatg ttcaatgaaa taaaaggcca gatttaaaaa tttggcaagg 3181 agttgaaaac tataaaaagg aaccaaataa aaattctttt tttgccccca taaggcagaa 3241 gaaatacaaa ttctacaact gaaaaaatat aatatctgat attaagaaat caataaatgg 3301 tttattatat tagctacatt tgaagagaca actaaaaaag aaaaatattt tcaaaccaac 3361 tcagaaacaa gaagatggaa aataaagaat acaatgctat ttatatttat atataatagt 3421 atatataata cacaagttta acataggact gcatttgcag aatagaagag agataatggg 3481 gagatagcaa cacttggaga aaaaataacg aacacttttt tatttaaagt gcctaacttg 3541 gctgggtgtg gtggctgaca cctgtaatcc caacactttg ggaggctgag atgggtggat 3601 catttgagcc caggagttca agaccaactt gggtaacatg gcgaaacccc atctctacag 3661 aaaaactcca agaaataaaa aacaataatc atctgagtgt ggtagcacat gcctgcgtcc 3721 ttgctactca ggaggtgggg gtggcagaat taccagggcc tggaagtcaa ggctgcaatg 3781 agctgtgatc gcatcactat acttcagcct ggttgacgag tgagaccctg tctcaacaaa 3841 taaaaataaa aataaaaata aaaatgccta acttggtgct tggcactttc taaaattgac 3901 acataatatt tgcacctgtt tatggagtat atgtgatatt ttgatacatg catacaatgt 3961 gtgtaatgat caaatcagga tatttaagat atccatcatc tcaaacattt ttctttgtgt 4021 tcagaacatt ccaaatctag ctattttgaa atatacaata aattattaac tatagtcatc 4081 ctaatgtgct attgaatatt attgaattcc atctaattat atgtttgtac caattaacca 4141 atctctactt attcctcacc cccagctccc accaaccctt tccagtctct ggtaactatc 4201 attttattct ctacctccat gagatcaaat tttttacctc ccatatcgtt gtcaatatta 4261 ttatttttcc caccctggct cctaatgaag gatttattga caatatcact ggaatctaaa 4321 tcctctaggc cattttttca ccaatgccct tattttctta gggctttttt ttttcttaaa 4381 tcaacagttt taatgagata taattcccat tctataaaat ttcctcgttt gaagtgtaca 4441 gtttaatagc ttttagtata tccacagaag tgtgcaacca tcaccataat aaattttaaa 4501 acattttcag cagggcgcag tggctcacgc ctgtaatccc agctactcag gaggctgagg 4561 caggagaatt gcttgaaccc aggaggcaga ggtttcagtg agccgagatt gcaccactgc 4621 aatccagcct gggccacaga gtgagactcc atctcaaaac aaaacaaaac aaagcaaaat 4681 aaaacaaagc aaaataaaac aaaaccaaaa cccaacaatt ttgaacattt tcatcttacc 4741 accctgccaa aaatccctgt tctccttagc catcaatctt cagctcccta cccacttcta 4801 accatgaatc tattttgtag atttgtctat tctcgatatt tcatatgaat gaaataatat 4861 aatatatggt tccttgtgac tagtttcttt cacttagtat gtttccaagt tcatccatgt 4921 tttggtatgt atcagtactt cattcctttt tatcatggaa taatattctg ttgtattgat 4981 atactacgtt tcattcattc atctgaacat ttggattatt tccatttttg tctattataa 5041 taattctgct atgaacaccc atgtatacgt ttttgtgtgg acatgatttc attttccttg 5101 gatatacacc tagcagtaga attgttgagt cataaagaac tctaggttta gctttctggg 5161 gagcttccag attattttcc aaaatggctg tgccatttta cattcccacc agtaaagtat 5221 gagggttcta atttttccct gtcttcacca atacttgttg ttatctatct tttttattat 5281 agtcatcata gtctgtatga agtgatttct cactgtagtt ttttcagtag taattaaaaa 5341 atttcctacc tattttagcc taaaattact ttcctgactc tcttcaagga gcctgccaga 5401 gaattctctc tctcgtgctg tctcccttat gcctgggcat aagctctgat aatgccctgt 5461 ctgggaaaac tcttttggcc ttctcaattt ctattacatt gagagcccaa gaacccatgg 5521 tcagtaacag gccaatgaga agcctcctgc attagtctag gtgaaggata atggtggctt 5581 ggaccggaat auggtggtag tcatggaaat ggggagaatt tgacagacta gatttatttt 5641 ggaaatagaa ctgaatctga acagattgaa ttgggcaggg agcagggaaa gtgaagggga 5701 aggaagacac caggtttatg ccttcagcat ttgggtggat gaatggatgg atgaaaggat WO 00/09525 PCT/US99/17712 EPI-109 1214 5761 agatggatac atggatggta gttagazgga gagtggttg gatgaatgga cggrcaaggg 5821 gtgaataaat gggtggatgg aaaatggaga .atgatgaac tgagatgggg aagactagaa 5881 gtggggcata tttttgggga aagacagttt t:caatacgt taagtttgag gtgcctcaga 5941 gtcataagag aggatttgtc agaaaggCag ztggatataa gattttgaag ctcaaaagac 6001 agggagggcc tgatggtatg tttaaaccta tacggatatc acataggtaa catttcaagc 6061 ctaagaaatg ggccgggcgc agtggctcac acctgtaatc ccagcacttt ggaaggctga 6121 ggcggqtgga tcacttgagg tcaggagttc gagacaaacc cagccaacat ggtgaaaccc 6181 catctctgct aaaaacacaa aaattagtgg ggcatggtgg cacatacctg taggcccagc 6241 tactcaggag gttgaggtgg gagaattgct tgaacccggg aggcagaggt tgcagtgagc 6301 caagattgcg ccactgcact ccagcctggg caacagagca agactccgtc taaacaaaac 6361 aaaacaaaaa aagccttaga aatgggcaat accaccaaag cagaaagatg aaaggagggc 6421 aatgccctga ggtgtgccag cattggagga aacaaacagC cagagatgta ggaggaaagc 6481 ccaqagaaac tgtgagctgc aaggatgaag tagtaacaaa taaaatgcca ccaagagaac 6541 cagaaggacg actggaaaca aataaacaag aaagactatt gcatttagca acgtgaaaac 6601 gttggattac tttttactca gaaatcaaac cccaaggata gtgtttcccc tccctacggg 6661 gtttctgcag gtccctttac acgccccctt ctacttcttt aagtgctaaa agtgattaat 6721 ttggggtgat gttttaattt ctattctttt tggcttataa ctgtgttttt tcattctttg 6781 caacaacaga tagtatgttg taatagaaaa atccattgtg gtcaatgata acttctgcct 6841 gttcctgggc acagggggca tcactattag tgcctgttcc tccctcccta ctgctgataa 6901 ggaaacaggg gcaggaataa tactaataat ttgtgctact ttttctgcat acccttggcc 6961 ttattctggt ctactgagct gggagcttgt ctgaggctgg agctctattg tctgaatcca 7021 ggggcagaaa gaactgaggg ctcttttacg gcatccacct ggaggctgcc tgcaggcttg 7081 ggttgctaag tgcactgctt aatttagaag cgccttttat cctggctctc ttgaccagtc 7141 aaagttgtgg tcgctgtttt ctacaaggac tggggaaaga aagggtggaa ttaattaaac 7201 ctggaggaaq ggactttgaa gggcggagct aaggtcaaag aaagaaccct ttaaataaag 7261 ggcccacact ggctgccagg gagtgcgcag gactggcaag agggaagccg ggctgctcca 7321 cgcctttcac gccttccacc tcctgcgtgt ccatctgtga gaaggagcca gagcccaagg 7381 gagatgatgg agcctgagga gtacagagag agaggtgagc aacgggcatc cctggccctc 7441 ttccctgctg ctactcctgc aggaacggct gctggtgggt ggcccttaga ttgtggggtg 7501 acatttgatg ggagcattag aattgccttc tgagagttgg caccagcaac attttttttt 7561 ctgcgaaagg aatgtgggat cagagtgtaa aacttttctc aaccactctt tcattctccc 7621 tctcatatac ccactctcac atatgtccac actaccgtgc cttgcttttc ctccccactt 7681 tcccacaaaa ttgaggattt ggatccctga gccactagat gggaaaaggg gattgttcat 7741 attctgaaat agaaaaaaat tttctcaata ttctgtaatc actgcaaatc ctttctttct 7801 taacattcat tccttcatgt gtgaatctat cagcagtgtt ctttcattta gtcattcatt 7861 tcataaatat ttagtaggtg cctactctgt atcaggcaaa accaagtggt tatccagttc 7921 tcaggcatgg atctccctta gcaggaaagt aggtagttgc ttaaaaaaga atcttgaatg 7981 tctatttcta taatgtttta tatcctccta ctcactaatt agtgtgcgtt agcttattcc 8041 attgctttcc taaggcactg tcagctgaga gcaagttcct gtggatattt atcttctgag 8101 tggaacacaa atacatttag cactgttcct ggatcagtgg agggttaggt ctagagctct 8161 cagatctctg gtggggccct gctggagaag aaccaggatg tgagagggtt gaaggggagc 8221 agaaggaaga tagaatggtg tggaaatcta cctttgtctc ataagttttg tctggggttg 8281 gttctgttct taagaacttt gcataagctg atgcagaggg gagaaactga gtcccctctc 8341 ctaggtaaaa gcagcccagg gagtactaag gaatggatgt tgagacagac aaagagatat 8401 gtacacacac acacatgcac acacagcaac agaggcactg aagactgcaa tctgaaagaa 8461 taaataattt gcaatagttt cagagtgttc aacttgactt ttttttcctt ccttactcat 8521 atgttcattc acttgataca ttttttttta gcatctaaaa aatatcctaa gcactgaggt 8581 gttgatggag gcagcaggag ggagagaaag tcattaagat ttggtgccac atttcccagg 8641 ccagggcagg gggcttggtc tggatccatg gttgtgcttt agggattctg tgagcctcag 8701 aaattataca caaagttctg tgtatatgta agcctacagt tttaatcaga ttcttgaatt 8761 aagtcctcat atgagtccaa aaaagatgaa taataactga ttcaatgggg atggtgaaaa 8821 aatagatttt tttgtccttt atcggaactg ggcatggaat ctttctatct gtgctaacag 8881 atataactgg tgggtgtgtg tgtaacaatt tttggataca aagagctata gagtttctat 8941 tgaacctata aaatagttaa tagatgttct gtttctgaga aggaaagaaa ggtaggagag 9001 acaatcaaaa ttgaagtgga taaaggaagg ggaaagaaaa tgaaacgttt cactttggcg 9061 ctagagtttt gtgctttgga gattttcctt tttgttcatt tgctcactta gaaactccct 9121 ccatcattca ttcactccct cactcttttt ttaaattctg aagataaggt cgtgcagggg 9181 atcagatcct accctcggcc catgaatctg tctctctctt ttttttgagt ccaggctgga 9241 gtgcagtggc acgatctcgg ctcactgcaa cctccgtctc ccaggttcaa gcgattctcc 9301 tgcctcagcc tcccaagtag ctgggattac atgcgcctgc caccacgccc ggctaatttt 9361 ttgtattttt agtagagagg ggtttgacca tgttagtcag gatggtcttg atctcctgac 9421 ctcgtgatcc gcctgcctca gcctcccaaa gtgctgggat tacaggcatg agccactgtg 9481 cccggccaaa tccatctcct tctttaccaa gtctcttggc ccggacctga gagggatggg 9541 cacaaatcgg tcaggcccag tcaggggatt tcagcctgat ttctctatgt cacttctagg 9601 gagagagatg gtggattaca tctgccagta cctgagcact gtgcgggaga gacgtgtgac 9661 gccagacgtg cagcctggct acctgcgagc ccagctgcct gagagtgctc ctgaggaccc 9721 cgacagctgg gacagcatct ttggggacat tgaacgaatc atcatgcctg gggtgagaca 9781 cagtgaccac aagggcagtt ctggatttca gggcacagaa gggtgggtgg tggcctggag 9841 aaagacctgc tttgggtcag cttgggatga gaatgcatcc ttcagccact tggccaccaa 9901 caccccagcc catctgctag gcatgtggag ggcaggactt tgactggtat taggtttctt 9961 tttctttttt tttgcccagt tgtgccatgg catgaggttt ctgatgccag ggcagggctg 10021 gccagaacac ctgcattcca gagcacagcc tggcagaagt gtggaagtct aatgggatgg 10081 gtggagaagt gaacattttg tctgagggga aaggacactg tgtatagtaa gacaggggag 10141 aggaagctgg tggtagtgcc tggccctgac gacggagcca gagactcttc tgtacagtgt 10201 ctgagaccac accaaagaga aggaaggaag tggggaacac atcctggcaa ggacacgctg WO 00/09525 PCT/US99/17712 EPI-109 1215 10261 gcgaccaaz tgcgta: caagaaactg agrgggccct ggcaacccct cctgtccccr 10321 ctgaggtctg gtgattaac tgcttttcaa gagcaaaag ggactttccc tgaatcattg 10381 atactttoca ugatggaag Tgcagcctgg gatagtgctg gtggggccag gaagctgatg 10441 gaagctggct gatgcatagg cttgagctgg agcctgczt gatgggtggt ggacacccct 10501 gaccactggc ggtgaggagc tctgccatgg tgctcatgct aaagtggcat cgactccctt 10561 cctgtggcgg ggctccctac catgtgccag ctctgtgctg gccacatgac atgctatcta 10621 atttaatctt cccagtggc ctgttttaca gatgaggaaa ctgctgatgc tcagagaagt 10681 taactgtctt gcccaaaarc acagaattag tacctggtag atccaggatt ttaccctaga 10741 ccagtcttac ttcacaggct gtgccgtttc tcctaccccc tgtcacctct actggtgggt 10801 gcctgaatgt gcctggctaa gcctgggccc ctagcattgc ctgtctggct ccacaccccc 10861 acacaaactg tgtcttccct ctccctgctt ggggcatttg tgttctgaac cacacatgtt 10921 tagaggctct tcctgaggcc agcttgaggt ttgccttcat cattcccaaa gaacttttga 10981 cttcaatgtg acaaaaaagc caggcgcggg ggctcacacc tgtaatccca gcactttggg 11041 aggccaaggc aggtggatca cctgaggtcg ggagttcaag accagcctga ccaazatgga 11101 gaaaccccgt ctctactaaa aatacaaaat tagctgggca tggtggcaca tgcctgtaat 11161 cccagctact tgggaggctg aggtaggaga atcgcttgaa cccgggaggc ggaggttgcg 11221 gtgagctgag atagcgccgt tgcactccag cctgggcaac aagagcgaaa Ctccatctca 11281 aaaaaaaaaa aaaqtgacaa aaatatgcct agaggcaggg gtgggaaaat attcaaactc 11341 agaaagtgat ggcaattttg actttttttt tttttttttt ttgaagcaat agagacaagg 11401 tcttgctatg ttgcccaagc tggtctccaa ctcctgggct caagtgatcc tcctgcctcg 11461 gccttccaaa gtgttgggat gagaggccta agccactacg cctggccatg agggcaattt 11521 catacaaagc cactcatctc tttgaccatt cagcctattt cacaagcatt ttttgaaaat 11581 gtcaatatca gtaaggcttt acggaggcta gatcctgata agattatctc ctggatttta 11641 ttctgtaaaa tgtaatctgc tgaggggcta actgtaatct gggagtgaga ctgaaagcaa 11701 ctgtcagaag aggtggaaat gagctgattc atttgatcaa gaggaattcc agcagttgct 11761 gtgggtatgg tcggtgaggc tcatttctgg aaagaggtct gtttgttttt gataagggct 11821 cttctggcta ttttatctta tttatcttac aagaacagac tattgtctct tgatagagct 11881 aggaggtaga agcccttctc tggggtttcc aaaatactgt cactaaggac agtgataatg 11941 atggtcaaat ctctcaactc atctctcagg ccacaccagc ctctgagagc tggcctgaaa 12001 gcagttggcc ctttgcttac tcattttgct cagtgcctca ttgaaaactg aattagtttt 12061 tctcttcctg ccaccaccta gaaaataaga gaagaagaaa aactctcttt cccctttaat 12121 tccaaccctg gttagacaat cctcatttac ttttcatgag agagagagag catccccacg 12181 ggaaaagtca ggacaccacc ctgctcgggt gtctgggctt ctgcctcatt gcggtcacct 12241 gtccctatgg ggtatgtgtg accacaggga tgtggcctct ctctgtcagc cccagttctc 12301 gcctgcaaaa cagagataat gtgtaggtcc taccccatag ggtcctgtga gaagtaagta 12361 agagaaggct tggagagcag gagatgtggt tattaccgat catgactctt acatggtgaa 12421 aattggagga agaggtttga ttctctgagt caagtcagga tatgtgatgt gtctgtcacc 12481 cacatgatta gtttaccgtt aatgttagag cttaacattt cacacatttc ttgcccacgc 12541 ctccacccac acaacaaccc taggagacag gatttatttt acgatgagaa actgaggttg 12601 agggaggtgc aggagaggct cctggtctta tggggtctgt actgtaaaca ctttttgaga 12661 cctccttttg aaaaacaaaa aagaaggagg ccggacacag tggtgcacgc ctgtaatccc 12721 agcactttgg gaggctgagg cgggtggatc atgaggtcag gagttcgaga ctagcctggc 12781 caacatagtg aaacactttc tctattaaaa atacaaaaaa ttagccaggc atggtggtgg 12841 gcacctgtaa tcccagctac ttgggaggct gaggcaggag aatctcttga acctgggagc 12901 caggggttgc actgagccaa gatggcgctg ctgcactcca gccctggtga cagtgcgaga 12961 atctgtctca aaaaaaaaaa aaaaagaatg aatctcaaaa gagacccaca caaatggtat 13021 gttggagctt aagttcatta gcttcatggt aaatctacac ggtcacacag ctggttaggg 13081 actgaggtgg gatgggaact tgtgtccttg gacttaattc ttaggctcct tatactatac 13141 acactgtcca ggacaaggtc cttgctcttg aaggactcta agtatgtgtg gacagtaaag 13201 aacaggatga tgccctaaga tgttatcaaa tgagtcctca gtagagtgaa acatctagaa 13261 ttctagagtt ctatcgctca gggaagggat cgaagggagc tgtgggagct gggggagagt 13321 tcgaggagga aatgaatatt tagtagcttt ctaagaactg gcaggttttg gaaggtcatg 13381 tctttataga gagtgccttt ctatcagggg acacagcatt gctcaaagac ataaatgcag 13441 aaaggaacag ggcatgcttc agagcagtga gatgaggaga gatgagataa tccatgaggc 13501 cgatgaacca ccagggctgc ttctgagttc tgatgggggg cccttcctgc ccactcagct 13561 cctccttaca tccggttttg attgtgggct cagggcttag cctggaggtc ggcctcccat 13621 acgcttggtc tgggctctcc tctctaccgt ctcctttcct cactacattc ccaatgtgat 13681 gcttaaggac agctttgaac ccattcaccc agaccctctg agttgcatgc tcagggagct 13741 cagtgctcca taaaacaaaa acaaaaggtg ccttttgcaa gaaactggat gaaacaagta 13801 gtctgctttt ctggagctca cagtctgccc ttcctttttt ttttttgaga cggagtcttg 13861 ctctgtcgcc caggctggag tgcagtggag cgatcttggc icactgcaag ctcagcctcc 13921 cgggttcaca tcattctcct gcctcagcct cctgagtagc tgggactaca ggcttctgcc 13981 accccgcctg gctaattttt ttggtatttt tagtagagat ggggtttcac catgttagcc 14041 aggatggtct caatctcttg atctcgtgat ccacctgcct cggcctccca aagtgctggg 14101 attataggca tgagccaccg cacccggcct gcccttcctt ttattgctgg gcaggggcgg 14161 catgaggggt aagtactggg gactaatgtg aataccaccc agaatcccac aactgggtta 14221 ctgtagtgat tttccttttg catatttcct tctggacttt gcatatatga aaaggctcca 14281 ctgatgatct agoataggac atgggccaca ttagtgacaa gaacaccagt gaacaagtct 14341 gattttcatg gagttatgtc acttatttct gcttaaaagt gtcagcccat ctctagagtg 14401 acacttcacc ttgccagaga tggtctctgg agaaagaaag cctgctggaa atgcctcctg 14461 gtgccaactc tgtgcatgct ctgcctccag gtggtacatt ggcagagccc ccatatgcac 14521 gcctactacc cagccctcac ctcttggccc tccctgctag gagacatgct ggctgatgcc 14581 atcaactgct tgggattcac ctgggtgagt agcaacggct gtaactactc gcaatgggga 14641 acgtagcagg gagtggtatc ctagggcaga catattttgt cttggtttct gaatatggct 14701 ccacaataaa tattaatgag ggctatattc tttaagctta cgctttattt taattttctc WO 00/09525 PCT/US99/17712 EPI-109 1216 14761 atcacatcct ttaaccctat agaatcacqa gtattgatcc cat::a gtgaagaaa: 14821 cgaggcttaa gcaacttatc tcccccagat cacacagctc atagagacac agataagact 14881 tggatacaga tctggttatt gccacagttt gtgaccttac ctaagcaazt tgatgcctat 14941 tgagtcacca cttcctctgt gctcttgtat ttgagtagct ggagatatgt cctaagacut 15001 cccttaataa ccccttaagc accactcagc tttaaatggt gccaaaaacc ttccagaaca 15061 tctttttatt ttaagcctga actcctatgg gtgtgtgggt gggtgggcgg gggtattcat 15121 atcttttcta ggaaaacatc cccctgggca tttgaggact tctcagctat gtattttagc 15181 gacttggaga accaaatcca agccaaCCat ttctagggct gtttctccat agagccttgg 15241 agaattcgcc tcattgaggg cagcatgaat ccaaaacccc acattatttt ctcttttggt 15301 tgacagagag tggaccagga gagaggcacg tggcctaaca tgacccctc tccagaaatg 15361 ttcccattga caccatcagg ggcagacatg tttctggagc tcqtgggggc acctcagtgc 15421 cctggggctg tgcagtttga agttcctttt cctttctcag gcatccagcc ctgcgtgtac 15481 agagctggag atgaacgtca tggactggtt ggcaaaaatg ctgggactzc cagagcactt 15541 cttgcaccac caccccagca gccagggcgg aggcgtcctg caggtacctc ccttggcaaa 15601 gcttcaccta gcttgggggc taagtagcga aagacaagcc aaaccctaac ctggcaattc 15661 tcccgttctc catggagttt cccccacatt acccacaccg tcatcaccaa cagcaccatc 15721 atcacagctt cacctctact cccacctcag cttctgcttc attcacatgt actgctactt 15781 cctttgaaag aaattaaaga gccaacacat gatcacattt ccagtatgac ttgattcagg 15841 tttcttagtc tataatctga caattccttt ttggtgtccc attttgtatc tcacggtaaa 15901 aggggaaagg agaaggcaag gagaggactt ctctttctct ccctgctagg ttcaggagat 15961 ccccttgcag tgagagcaat taacagcata aactgattaa cggtatccrc tgaccctatc 16021 ttctggatac ttgtcaaatt atggttcttc aaatatttct ttttttcaag agtagtgcca 16081 tggagtggag ctttctgggt gcctcccatg gaccacacac attgttaggt gcttttgcat 16141 ctataaatcc ttgacgttca tgagggcttg gttctaagac ctttgagatt cctcagattc 16201 ttgaattctt tttttaaata aaaatcgtgg ctggacatgg tgactcaccc tgtaatctca 16261 gcacattgag aggctgagac agatggatca cttagcccag gagttcaaac cagcctgggc 16321 aacatggtga aactgatctc tccaaacaaa caaaattagc tgggtgtggt ggcatgtgcc 16381 tgtagaccca gctacttggg atgctgaggt aggaggattg cttgagccca gaagattgag 16441 gctgcagtgg gctatgattg tgccactgcc ctccagcctg ggcgacagtg taagaccttg 16501 tctcaaaaaa taaaaaaatt gccatgttgc tctgagatga gaaccaggaa gttcactagg 16561 tcctcttgct agctaagtga ctccctctct cactgcagcc ttgcagcaag attaaaatct 16621 gaacctcgga agaaagacaa attgcagcat gttgtggaca ttttggattg tcagcaaata 16681 gttacaactt cagatatcat atttgggaga acatgctaaa tgtctgcggt acatgatctt 16741 gcttttcatc tgattatctc aggaaccctg caggtgaata gtaccattCC ccaatgtttt 16801 gagataagag cactgaagtt cagagagatt aaataatttg ccctagctta cacagctgat 16861 aagcagaaga acgaggattc aaactgatgc ctgtctaaat ccaaaccatg ctttctcctg 16921 tatcgtcagc catgtgaact tgagttagtc ccatcacctc tctgagcatc actctcctca 16981 tcttagtgtg acaagaatca taattatctc aaagaggtgt tgtgaggagc aagtagaatg 17041 ccagaaagtg ttttgtaaac tatgaattgc aatacagatg gaaggtgttg ttaccattat 17101 tattattttt aaaaacaggg cctggttctg tctcccaggc tggagtgcag tggagccatc 17161 atggctcact gcagcctcca tctcctgggc ccaagcaatc ctccaacctc agcctcccac 17221 gtagctggga ctacaggtgt gcaccactac acctggcttt ttgttttttg ttttttttgt 17281 agagacaggg tctcactatg ttgtccaggc tggtctcaaa ctcctggact caagggatcc 17341 tcccaaagtg ctgggattac aggtgcgagc cactgcaccc agctgattat tattattatt 17401 atgctacata cttctttaca taaatagctt tctttttatg gagtaactcc caggcactta 17461 atatctgtgg gatctggtcc acaccactct ccatgacagt gtctgccagg catttttagc 17521 aggattctat cagctgtagg tcacttgaag atttcaagaa gcaaagacat caaagactgg 17581 gtgaatgaat gataaggaac cataaagact cctgtgaagt tcctgaggtg gccccgaaga 17641 tttccacaat catggccaga gcaaaatcct acccaaccct tgtttggata atctatactc 17701 ccatcctggg aagcagttaa agggatgctc tccatttcat agacagaaaa gagtcttctg 17761 gaggggaaat gttagcccaa ggtcacaaga gctattgaca actaaatggg cccaagtcac 17821 cagcctctca cacaggocag gatcctctct tcctggggac tcaaactcca tatccatttg 17881 tgtaataagc tgagagttct tcttttaaat atgttttaca tggggagcaa acacatccag 17941 gagggacaga acattctctt tttggtttct gtggcctctg taatagagag gctggtatta 18001 ggtgcaaact tattttagaa ggcagaatag gaatgaaagt tggggaggga catgggcacc 18061 ctgggcagga ggagctgtgt atttccttct gtgaatagct atgacacaca catacacaaa 18121 cacatacaca cacagagaga gagagagaga gagagagaga gagagagaga gaaaaaacta 18181 gaaagcctgg ggaaatttgg caagagaata cagaaaggct gccatgataa tccttttccc 18241 ctgcagagca cggtcagtga atccactttg attgccctgc tggcagcaag gaagaacaaa 18301 atcctggaaa tgaaaacgtc tgagcccgat gctgatgagt cctgcctaaa tgcccgactc 18361 gtggcctatg cctctgacca ggtgagttgc ccgacgcagg acagcccttc gggttggtgc 18421 ttggcttctg gaatcttggt ccttgagcaa tttttttcta gacgtgagta cgctggggtt 18481 ctgagcagct cagacatggg agcttgtctc cagcaactgt agggaagaca agcttccaat 18541.gatcatattt ggttcccgag tcttaggctt cagcagtttc tggggggtga tcattccagg 18601 atgactcttt gctgacaggt ttctgtggcc cttctaggct cactcctctg tggaaaaggc 18661 tggtttgatt tcccttgtga agatgaaatt tctgcctgtg gatgacaact tctcactccg 18721 aggggaagct cttcagaagg ccatcgagga agacaagcag cggggcttag tgcccgtctt 18781 tgtaagtcag gatatatgcc taagcttaga atgatagaaC ttggatgtga ggaaggaatt 18841 ttggcagaat tcaggtaagt aacatgctgc acacaaaagc agaaaggtcc tcccatacag 18901 tattttacac atcatgaggt gctatccata ggtgtgttat ggaataaatt ttgtgggtca 18961 taaccagcat taaaaagaaa tatagtataa aatattagag tgcacacata tagccagagt 19021 atgtattgtt ttatgaaact tttttttcaa atacacacgt atacatgtac tagattgtta 19081 tataaaatgt gtttcttacg agccatggta aaacacagtc tgaaatatac actgttctgg 19141 tgggatggat gggagtagat cacgtctgtg gtgaaatctt tctcaggcca aatgtgtcac 19201 acgagcccac cctcctgtgt taacttgcct taattttccc ctaggtctat gcaacactag WO 00/09525 PCT/US99/17712 EPI-109 1217 19261 ggaccaczag ggtctgtgca tttgaczgcc tgtcagagct gggccccatc tgtaagtatc 19321 tt ctczat ggctaggaag acaaggaata catttttaaa tgtctcctaa agcaaggacc 19381 tgaaaccagc tctatgggat tattcttgtt cctctttggt caatgcagag acatgggaag 19441 aaccaccaaa ggtcatgagg gtctcttcca gggatccctg gacattgcct ttcccagtgg 19501 tgtgacaaaa gttagaggtg gcctaccttg cctcctgtcc taqgaggcga cagtaggaga 19561 gccttcggtt ttctcatcct cttacttgta tgttgaactt tacttaatgc aggctatatc 19621 caaaatacag tgtgaattag gctagaatag aaatgctttc tattctacct tcagaaaagg 19681 aaaagggtag ggtaggggaa atcatgggag agattaaagg cagagaggaa acccagatgg 19741 gactgtttaa tccccaagca agaaaccact aggaaagaga gataccttcc ctctaacttt 19801 tgtattcggt gcactgacat tgctctctgt gctggtggga aattgatttc tgtgccagga 19861 tgttctaaac tgaggccaag agggtgctgg ccctttaccc agtggaagaa aaaggcaagg 19921 gtgaggcttt gtagactttc ccattcggag gtaatgatgc ctccttcagc cccacttctt 19981 caaactgact ccacctgctc ccatctccac acccctccgt ttctcattta gccaaagcac 20041 atcatccttg cagcccacca ctcagcttgg ccaggtgcga gacatctttc cccacttcat 20101 acctcccctc cggccaggtg atgtttgcct cctcaggtgc ccgtgagggg ctgtggctcc 20161 acatcgatgc tgcttatgca ggcactgcct tcctgtgccc cgagttccgg gggtttctga 20221 aggggattga gtatgccgac tccttcacct ttaatccttc caagtggatg atggtgcatt 20281 ttgactgtac tgggttctgg tgagtgtagc agcccagctc cgagcacgca ggaacgcctt 20341 gcctcctctg gagagacctc agccactaat gcccatttgg aaacccacag ggtcaaggac 20401 aagtacaagc tgcagcagac cttcagtgtg aatcccatct acctcaggca tqccaactca 20461 ggcgtggcca ccgacttcat ggtgagtggc cagggacggg cagcctggtg ggctcgggtg 20521 gccagtggga actgtaggcg tctgaccccc caaaatctgt acggtggctc ccttcagaag 20581 gcagcacact atgagctcat ctcataatac tgccaatgca taccttggtt tctaattgtg 20641 cctaagtata tagaatgaaa cccagaaaat ggttaaaaac cctagaaaat gagaccagcc 20701 tttgaggcag tgtgcacatt tcctgaatat ttgtggcatt ttttaattcc cagaaatgct 20761 cttcctacca caggtggacc agttccttct gcctccatct cgggtcatct tttttgtttc 20821 ttacccagca gcagggcagg gtggagaatt tccctggtgg ggaaagagct ttcttgctga 20881 aatcgctttt gtttttttgt ccctgacaga ggcgctgtgg ggcagctctg tggtagtgat 20941 gggctgcagg acttgtgtga ggttctggaa gcctccaagc attcctgact ttcccaactg 21001 actgcgcctc aactctctaa ctcactctct ctctcttttc ttttgttttc tttctttctt 21061 tctttctttt tttttttctg agacagagtc tcgctctgtc aaccaggctg gagagcagtg 21121 gcgcatcttg gctcactgca acctccgcct tccaggttca agcgattctc ctgcctcagc 21181 tttccaaqta tctgggacta caggcgtgag ccaccgcgcc cagcaaacct caactctctt 21241 gattccacat cctcagccag tattttgcct gagggaaacg agttcttaac aaattgactc 21301 cgcagtttga ggatgagccc ttcctttact tgtaggggag acagggatgt aaacgaatgt 21361 attacacata acctggccaa cggaggcagc agagcagagt gggggcaagc ttggtttgga 21421 attccattcc agcagtggcc ctttgggaaa ctaactggac ctctctgagc cttgctttcc 21481 ttatctgtaa aatgagaata gtggcattga ttcatagggt attgtgaagc ttaaatggga 21541 acacgtgtgg atcacctagc aaaatagccg tgtggcaagt gctcaatata tggtaggcat 21601 agtatttctg aaagctcttc tttgaagctg cagagatttg ttaggacagt ggttaggcat 21661 gtaggtgcta aagccagatg gcatgtgttg gagtcctggc tttctgttta ctaacttgtg 21721 tgacctcggg caagtgactt aaactctgtg tccagatttc ctcttgtgtc aaatgaggct 21781 gatgaccaca gttctggctt cttaggcttg ctgtgaggat tatacaaatt aatacactga 21841 agtgctgaga gcagtgtctg acccctgtaa gcatccttcc ttgtgaagag atggttttat 21901 cttatcttct tggacaactg aagtgtcttg cccttttagt cttaaaataa tagcttcgtc 21961 atcacttgat tatactggct attctccctt ggaccagtcc acaccctctt tagatatttg 22021 aagcttttgg attagaattg cagcggtaag cctcacggct tactggtggt gacagaagac 22081 cctctagagg taaagaaaga aagaaaaata atggttcttt atctccactg ctctttctgg 22141 taggttttca gagattttta atgaaaaatt aaaaaaattc cagaacagcc caagggtcag 22201 atatctttag ggataactgt aggtttgctt cctqagtgtg aattgatgcc cattctccta 22261 tgagtgtatt tgggtcatca taactgagga gcattatatt cacccttgcc cttttgaatt 22321 tcatgttacc gtttaaattc atttaccaca gtgcctcagg atcttcccgg ggttcattcc 22381 taggagtttg gagattttac agtgctctct gtcttccaga taactcataa aaatgttaga 22441 gtaaactctt cccagccctg ctctggggaa ccttattatt tttacctctc cacccagaag 22501 gcactgcctt acacttaccc ttcccccacc tttaatccta tggatttgat tttcaagtcc 22561 atgaagaaac tcctagaaaa gtgaagttgc tatctttttc atgatcctga gggtcctcag 22621 agctactctc acctgggccc aatgtctttc ccacccaggt ggctgcagct ttgaacagaa 22681 gctcagtcct gctctgagat gagccagaaa cagggcagca tcccaggaga gaagacttag 22741 gtgcttaacc cctggggtcc tggaatcacc taaaatcagg gctagattct ctgacagcgg 22801 agaagctccc tgttttctgc ctctcactgg acagagagca ccagtggagg gagcgttacc 22861 ttagccttgg caagggagcc ctgcaaggac cttacaagga cacagaggag gctggagatg 22921 cctcaaggta aagaagagcc ctgtcaggct ttatacgtcc agattttttg atccaacaga 22981 aaatgttggc tagaaccact ctgctgagtc agcatggatc agttttggaa tagtgacaag 23041 aaaaggagca actgggaata aggaagattg tgaagaaatc aaaataaaat cacctctgcc 23101 tatcctggtt tatttgctgg taaaataaag tagctctctc tatatatgaa ataaattggc 23161 tataactatc tggaaaccag aaccttttga cagatgatcc ctatcatccg ttcattattc 23221 tcttggagtg tccattggac aagaggtgga gttgacactt tccttgttac agcaattttg 23281 ttccattttc aggttttgat gccttctgct ggcacaaaag cccccaagct gctccccagc 23341 acaacagagt tttgcttgga aatcaaaggc ttagtagttt tctgctgggg aaacattgtc 23401 catcaacaaa ggggtaacat cccaactgtg cctggctcag gaaactgggg tgaagggtga 23461 aggtgaggac atttgtgagg atttgataat cttgtgtatg ggcagataaa tacgcagtgg 23521 gacaaacatt tatttttagt caacagaaat tgtggtagaa actttctgac gtttgagqga 23581 gatgtcatta ggaaaccacg tgactcatta gaataactgt aaatgttttc caaatcctct 23641 gctctatttt cagatctgag aaatcagct gaaattgatt tggaaatttt cagatgtatg 23701 gtgactgcaa ccttgaactt taagcccgt tgaatttggc caccaggagc aaagagtcaa WO 00/09525 PCT/US99/17712 EPI-109 1218 23761 ttttcatcta acagcggcag aaatttgggt actcatttga aatctgacag ctggagtgat 23821 ggctctcaga tcacaggaat ctcacaggaa aatgaacaag gcagtgtaag gttaaatagg 23881 ggtcatcttg gctctagaca gaaatgctac :gtgatttgt agctcacatt ttaaaataat 23941 ctaaatagcc aacacctact gacaacttct tctgaggctc ttggcgttct ttgtcctcac 24001 accacttgcc cgggaggtgc aattggttct ttatgtcccg gactgatgag ccagtgaggt 24061 ggcactaccc aaggtcacac agctagtaag tggcacagct ggaggcgaaa cctaggtctg 24121 cagggctcta gtgtctgtgc tctaactacc atactttaca ttttgggagg aataaaaata 24181 gaactttatt tctgctatt caaggaatat agattcattt agagtaaaaa tgtatttccc 24241 ttatgttgag tttctgggcc gggatgaaat gtttaaagca gcacttgaaa gcaaagtgcc 24301 cttctcattg gttcagggta atggacttga cttccacttg tctggctctc agacaagtga 24361 ctattggcca ccttcatcag tgatttggtc acacgatggg gcaacCCttg gggagcttgg 24421 cttactcctt agcaacaact cccagagtca tggtgacatc gtccatccct ggagggctgg 24481 gcaggcaaca gataatgccc agaaatgccC gagggagtgg ggcacccttg tctctaacct 24541 tgggcactgt gttcctttgt ttctagcact ggcagatccc cctgagccga cggtttcgct 24601 ctgttaaact ctggttcgtg attcggtcct tcggggtgaa gaatcttcaa gcacatgtca 24661 gacatgtatg tagcatgctg ctgtgggggc tgagcctgtg ttcctctgtt ttctcatggc 24721 gaggaaggct ggtttctact ttgcagatct gcctaggaga cttgcggtgt gtggttcagg 24781 tgtctgggcc tgttcctcag ctcctgggac ttgattctct ttgttaacca gaggagcgct 24841 gagcacaaca tgccctgagg gctgcctgat gcctgtcctc tgctgagtgt ctcaccgttc 24901 cccttgctgt cactgagcac tggggagggt tggccccaga gtctggtttg caggaaagag 24961 aaagagaaag taaatcaagg ggaagtgtgt gtggccaggg taggatccta tctgctttgg 25021 aattacctca atggtcacag ctggctgaat acttttagca ctattatgat tatgcctgaa 25081 ataaagctcc cctggccttg gacaggtaga cctaccaagt ctggaacaaa cctccctgca 25141 tcaacaggca tttattgaag gcctattttg cttaatttat ttctattcaa ttcaacaatt 25201 acaaggtatt gtgctaagaa agggacacag aggtaaatga gacaggtgca gcctctctcc 25261 catgttcttc atggaagaag cgggacttaa ctaagaactc tggccactgg cattgttctc 25321 ccacttctac aagagtccac atgcaagaca aagccattga taaaagtagt gggggaagct 25381 gaagacactg tcctttctgc ctatgtgtgt ctttgtcctt ccacctttcc tctagggaat 25441 tccttcttgg ttaaacaaac acaaaccaaa atgaagtggt ggaagcggta actatgattt 25501 tttttaacat ttaaaaaaaa taattattat gcttacataa taattacgta tatatttatg 25561 gggtatgtgt gaggttttga tacaggcata caatgtgcaa tgatcaaatt agggtaactg 25621 ggtatccacc actcaaccat ttatcatttc tttgtgttag aaacattcta gttccattct 25681 ttaagttagt ttgaaatgta cagcaaatta tagttaacta tagttgcctt attgtgccgc 25741 ctaacattag atctatttaa ttgtattttt gcgcccgtta actatcacct ctttatcccc 25801 cattccctgc tacccttccc agcctctgcc aaccatcatt ctactgtgcg tctccacgag 25861 ctcagtttgc ttacttttta actcccacgt ttgagtgaga acatgtgaaa tttgtccttc 25921 tgtgcctggc ttattttgct taacataatg ttctccagtt tcctatgact ggttttaatg 25981 ttggtaattt tacctttgta atcaccactg gttgtttacc aatgagcagc tgccaccaac 26041 aatattgagg aactttaggc actttgtgct gtttctagaa atgcagactc aagactggag 26101 ggttgtgggc ggggaatggt tggtggaggt tacaagtaat taggaacatt tttttgctta 26161 cagtttggga ctggatattc aatgtgcaqa tcctgactaa cctcccttag cacttctgtt 26221 tgcaaatcaa acccctgaat tcctcctatt agcaacccca ttgcctacca tatgaggccc 26281 acactcctgg gcctggcttt caaggacttg acgattagct cctaccttag cttgggcatt 26341 tcatcgaccc atccagacct catgctcagt ccatctctgc accttcaccc gtgtccttca 26401 cctgaactac cctctcctct ccaaatgttg tgaatggatt aaattctgct tccactagaa 26461 gcttttctgc ctattccatc tgttctggtt tctgcttcat tagcattcct gtgatcacct 26521 actcaaacac cittacaaaa ctgtgctcaa agttcttcca atgtcccaca atagaagaaa 26581 tggaattaaa ataaagttgt ttgatatgat ttgattttat ctcttcaact tgacggtgat 26641 gataattatt gacacttgcg taatgccttc aatacaaaaa taaattctag ttcttcatta 26701 gatccttagc acagtgcctg gggtggtcac tctaacctgg caaggctcag agggagtaat 26761 tgccctgctt gagggaagaa ggcccgggac tttccctgaa gcctcccaat tccaaatcct 26821 ttcttcatag ttctgggctg ctttctacta cactgagctc ttggaaagtt atataaaatt 26881 aaatttcata tttctgtgtt acagagaagt gctttaaaga atggattttt agttctaccc 26941 tttacctgtt tgatgacctt agacaaatta cttaaccttt ctatatttgt ctgccttatt 27001 tatttattgt tatttatttt tgagatgcag gtctctgctt gctcaggctg aagtgcggta 27061 gtgccatcag agctcactgc agccttgacc tccccaggct caggtgatcc tcccacctca 27121 gcctcctgag tagctgggac tacaggcgca taccatcatg cctggctact ttttgtattt 27181 tttgtagaga tggggttttg tcatgttgcc caggttgttc tcacgctcct gggctcaagc 27241 aatctgccta ccttggcctc ccaaagtgcg aggattacag gcatgagcca ccacccctgg 27301 ccatgccttc ctaatttata aaaatgagaa aaggatacta cctctctcaa attaaatgag 27361 ataatatata tgcagccctt agcacagggt ctacctacta ctcagttaag tactcaatga 27421 gtacctcttc ctcttctctt cttccccttc ttcatcatct ccttcttcat ctaattataa 27481 taaattgtca tcatcatcac catcatcatc atcatcatcc tcatctccta tcacctacaa 27541 tagggattgg taaacatttc ctgtaaaaag ccagatacta aatacttttg gctttgtggg 27601 ccatactcta ttgtaattac ctctgtacta caagagctac cgtagacaat atgtaaacaa 27661 atgggaatgc tgtgttccaa aaaactttac aaacacaggt gggggctata tttggccatg 27721 gctgcactgt gcctgccctt gacctagagc ggtgcagggc actggcagca gctctgcttt 27781 catgacctgt aaagtggggc tttggaggtg gcagtgctgc ctgtgctctg tattctcctc 27841 tcccctgacc tctgcttctg ttattgcaaa cagcatgtgt tgtaggaggg ataaaagcac 27901 agtgggagga gatctaccta ctgtcacttg taccttggga aagtcacttt cccttggttc 27961 cttctaaaaa atggaaagat tgagctgggc acaggggcac gtgtctgtag tcccagctac 28021 ttgggaggct gaggtgggaa gctcaattgc tcccaccata gcccaggtgg gagttctggg 28081 ctatggtgtg ctatgccaat tgagtgtcca cactaagttc ggcatcaata tggtgacctc 28141 ccaggagcaa gggatcacca ggttgcctaa ggaggggtga aggggcccag gttagaaatg 28201 gagcaggtca aaactcctgt gctgtttgaa actgaccacg caggggagaa aggggctctg WO 00/09525 PCT/US99/17712 EPI-109 1219 28261 agaaagattt ggagaaac:z at-ccattat ggtcaaaaga caggctcagg gccagacatg 28321 gtggctcatg ccagtaatcc cagtactttg ggaggczag gaaggaggat cgcttaagcc 28381 caggagtttg ataccagggt gaacaaccta gtgagaccac tgctttaca aaaaaattaa 28441 aaaatgtagc tgggcatggt ggtgcatgtc tgtagtccza gctactcagg aggtgaaggt 28501 gggaggatta cttgagctca ggagttcaag gctgcagtga gctttgattg tgcaacatgc 28561 ctctgtactc tagcctgtgt gacaaagcaa gaccctatct ctcaaaaaaa aaaaaaaaaa 28621 aaaaaaaaag aggttcagcL aactcccttg ccctctcttg aaatagagca gtaagtatga 28681 gaactaactg atagaattac ttagcaaata tttttattga gatcttctgg atgcttggag 28741 aaatttttaa aaagaaaaga gaaggcaagt cctgtccttg tttagttagt aatcctgggt 28801 taaaaacaaa aagcaaaaaa ccccaggaca tttaaaaaaa tggtatgaac ttcagtggaa 28861 gattaatata atacaaagcc tttaacattt taaaatgtaa caaaatattc ataccataga 28921 atgtaccatt ttactcattt ttaagtgtac aattcagtgg cattaagaat actcacaatg 28981 tggtgtgacc atcaccatta tttccagaat tttttcatca tcccgagcag aaactctgta 29041 tccattaacc aggtccaaaa cctttccatg atgggtggag acaagatgtg aaaatatgtt 29101 ctctatggaa tgtcagaaac aggggatgaa aagggcattt ggggtacagg gtgagaagag 29161 gtttgagagg caagtgaagc atgtaggctt aggatggggc agggccgcca ctagcccata 29221 tggcaacttg atgtgcacta caaacaggca tctcttcctt taggcacacg cagctcgcat 29281 gaggcacctg gctgggaacg cagagcatgg actgggtttt ggccctcact tgcccacttg 29341 gccagtcaag gagctgtgaa atcaggagtt gaggccgggt tgcctggact gcaaagcaca 29401 tgccttctgg gttctggggc tgagttgaaa gagggccctg agatgagttc tcgaggtgga 29461 tcccatgtga caggaaacag ggcgccattg gaaattttcc agcttggaat atgagcaaaa 29521 tcaaatggag atgacaatga ggcagaagcc gcttacaacg gctgtgacgg gaagatggcc 29581 ctggtttaaa accatttagc agtctgaaag tttatgcata gtctcttgtc tgatgattaa 29641 tctcagttct ctttatactt gcaattccag ggtactgaaa tggctaaata ttttgaatct 29701 ctggtcagaa acgacccttc ctttgaaatt cctgccaaga ggcaccttgg cctggtggtt 29761 tttcgtctaa aggtaatacc atcttccaag cccctctgtg aatgatgtct tgtggtgctc 29821 cagagcctct cggaaacaca aactgggctc tggggatgct gacagggggt gcgatggaga 29881 cttcacttcc tttatttttc aaacagggtc ctaattgtct cacagaaaat gtgttaaagg 29941 aaatagctaa agctggccgt ctcttcctca tcccggccac tatccaggac aagttaatca 30001 tccgtttcac tgtgacatcc cagtttacca ctagggatga catcctgaga gactggaatc 30061 tcattcgaga tgctgccact ctcatcctga gtcagcactg tacttcccaa cccagccctc 30121 gggttgggaa cctcatctcc caaatcaggg gtgccagagc ctgggcctgt ggaacgtccc 30181 ttcagtctgt cagtggggca ggagatgatc cagtccaggc caggaagatc atcaagcagc 30241 ctcagcgtgt gggagccggt cccatgaaaa gggaaaatgg cctccatctt gaaaccctgc 30301 tggacccagt tgatgactgc ttttcagaag aggccccaga tgccaccaag cacaagctgt 30361 cctccttcct gttcagttac ttgtctgtgc agactaagaa gaagacggtg cgctccctca 30421 gttgcaacag tgtgccagtg agtgctcaga agccactgcc cacagaggcc tctgtgaaga 30481 atgggggctc ctccagggtc agaatctttt ccaggtttcc agaagacatg atgatgctga 30541 agaaaagtgc cttcaaaaaa ctcatcaaat tctacagcgt ccccagcttt cctgaatgca 30601 gctctcaatg tggactccag ctgccctgtt gccctctgca ggccatggtt tagacacagg 30661 gccttcagcc agagtctgag gatatacttc agggactctg tgaacccctc acaattgtat 30721 gccaactttg tgtgcttatg tgtacatgca tttttcttgg ggcgagttca taattttaat 30781 caaattctca taggggcttc atgacccaca ataggataca aacgaagagt ttaagccagc 30841 atgatccaga tgggttcagc agtctggtca gtgagaaagg gccgagggta gacaggcagc 30901 ttctgtggtt cagcttgtga catgatatat aacacagaaa taaattatgc ttgtccctga 30961 aacaaaacat accctgtgtc acttaattgg ctgctgaaac attgattaac cagtctggga 31021 gcttaaacat atgtactttt tttgaagcat caattatgag tcaggcactg tggctcatgg 31081 ttcataaatg aggaaaccaa cgtttaggtc acacagcttt aaataggcaa acccaggtct 31141 cctgcttcca gtgaagccca ggctgtttcc accatgcagt actgctcaag gttggacctg 31201 aacaggagct cacagcccag caggctgctg gtcctccagt acatttaaat gtttcctttc 31261 taggtttgga acttgtgcat tttcccctta ttttcctgga cccggtagtc aaataaaagc 31321 tatgctcaca agtggcttgc ccataattag ttcagaggcc aaacacataa ttttatttcc 31381 atttcagatg gtactttgat aggttgtgac tctgaaatgg gttatgtaaa gagtattaaa 31441 gacaaacaaa gctgggcatt agttagaact ttaaggatag atgttaaaca gtaatatact 31501 atcacaatag ggaaaagggt cccatgtgaa ctgaactcaa cttggatttg tgcaaaggtg 31561 actaggcatt tcacagcgtg aatgggagaa tagggagaag gccagcctag acttagaaga 31621 gtcaggaatg tgaaaaatta caaaaagcgg aaagtggttg atgtgaaacc cctctgggtt 31681 tgctaactgg tgctttttga agtaagactc ttaccctccc acagagactg ggagtcaggg 31741 ccctgtgttc aggggttcgc tggaacaaac agttaattct ttcggcagct ttgagttttc 31801 ttaagcaggc actttaaggt gagctaggat caacttaggg atgtggcctt gagctgtgag 31861 aaactgtgtt agtgtttgtt caagtcttta taggcaaagg ttgaggccta gttgagaagg 31921 gggctcggag gagcttagct agagtttggt cgagaaaaga atctttgtta agagtttaaa 31981 gctttttttt tttttttttt tttttttttt ttgagactag tgctttctct ctttcccagg 32041 ctggagtgca gaggcacaat catgtcttac tgcagcctca acttcctggg cttgagcaat 32101 cctcctgctt cagcctccca agtagctatt tatttttgag atggggtctc attctgtgag 32161 tgcagtggtt ggaacacagt tcactgcagc ctcagcctct gaggctcaag ctgtctttcc 32221 acctcagtcc cacgagtagc tgggactatg agtgcacacc actatgcctg gctaattttt 32281 ataacttttt acagagacag ggtctccctg tgttgcccag gctggtctgg aactcctggg 32341 ctcaggtgat c (2) INFORMATION FOR SEQ ID NO:60: (1) SEQUENCE CHARACTERISTICS: (A) LENGTH: 2371 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single WO 00/09525 PCT/US99/17712 EPI-109 1220 (D) TOPOLCGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:60: 1 cgactaagaa gccctgztga cagctgcctt ccagcctcct ctgtctgtct gccaggagga 61 gcaatccaag ggagatgatg gagccctgtg aataccgtga ataccgtgaa tactaccgag 121 ctagagggaa agagatggtg gattacator cccagtacct gagcactutg cgggagaggc 181 aggtgactcc aaatgtgcag cctggatacc tgcgagccca gctacctgcg agtgctcccg 241 aggaacccga cagctgggac agcatctttg gggacattga acgagtcazc atgcctgggg 301 tggttcactg gcagagcccc cacatgcacg cctactatcc tgctcttacc tcatggccat 361 ccctgctagg agacatgctg gccgatgcca ttaactgctt aggattcaca tgggcatcta 421 gcccagcttg cacagagctg gagatgaaca tcatggactg gctggcgaag atgctggggc 481 tcccggagta cttcctgcac caccatccca gcagccgagg gggaggtgtc ttacagagca 541 ctgtcagcga atccacttta attgccctgc tggcagcaag aaagaacaaa atcctagcaa 601 tgacagcgtg cgagcccgat gctaacgagt cctccctgaa cgctcgtctc gttgcctaca 661 cctctgatca ggctcactct tcagtggaga aggctggctt gatttccctt gtgaagatca 721 gatttctacc tgtggacgac aacttctcac tccgaggaga agctctccag aaagctattg 781 aggaagacaa gcaacagggc ttggtgcctg tgtttgtctg tgcaacgtta gggactactg 841 gagtctgtgc atttgacagg ctgtcagaac tggggcccat ctgtgccagt gagggactgt 901 ggctccacgt cgatgctgct tatgcaggca cggcctttct gtgccctgag ctccgagggt 961 tcctggaggg catcgagtac gccgactcct tcacctttaa cccttccaag tggatgatgg 1021 tacactttga ctgtactgga ttctgggtca aggacaagta caagctgcag cagaccttta 1081 gtgtgaaccc catctacctc cgacatgcca actctggtgc agccacggac ttcatgcatt 1141 ggcagatccc cttgagccgg cgctttcgct ccattaagct gtggtttgtg attcggtcct 1201 tcggggtgaa gaatcttcaa gcacatgtca gacacggcac agaaatggct aaatactttg 1261 aatctctggt cagaagcgac ccttccttcg aaattcctgc taagaggcac cttggtttgg 1321 tggttttccg tctgaagggt cctaattgtc tcacagaaag tgtgttaaag gaaatagcca 1381 aagctggcca gctctttctc atcccggcta ctatccaaga caagctgatc atccgtttca 1441 ctgtgacgtc ccagtttacc accaaggagg acatcctgag agattggcac ctcatccaag 1501 aggctgctaa ccttgtcctg agccagcact gcacttccca gccgagccct cgggccaaga 1561 acgtcatccc gccaccgcca gggaccagag ggctatccct ggagtcagtc agcgagggag 1621 gagatgaccc agcacaggcc cggaagatca tcaagcagcc aggagccagt ctggcgagaa 1681 gggaaggcgg ctctgatctg gaaacgatgc cggatccctt tgatgattgc ttctctgaag 1741 aggcccccaa caccaccaag cacaagctgt catcctttct gttcagttac ttgtcggtcc 1801 agaacaggag gaagacaacg cggtccctca gctgcaacag tgtgcctatg agtgcccaga 1861 agtcactccc cgcagacgct tcactgaaga atgggggctc cttccgggcc agaatctttt 1921 ccgggttccc agaacaaatg atgatgatga agaaaggtgc cttcaaaaag ctgatcaagt 1981 tctacagcgt ccccagcttt cctgaatgca gttctcagtg tgctcgccag ctaccgtgct 2041 gccccctgga ggccatggtg tagagtcctc aatcagaatg caagggtgcc tgtgcttcag 2101 ggagttgggg aaccctcgaa attgcctgca gtttgtgtgc ttattatgtg tgtgtgcatc 2161 ttgagggaag caagcccatt attttgatca taacctcaca gggtcttcgt gatccacaac 2221 agattgtaac tgggaagttt aagcgggcat gctccagagg ttgcaggcgc ttgtgtgata 2281 gaaggggctg agacggtggc atgctgttaa gcttgtaatg tgaaaaaCaa cttagaaata 2341 aattgtgctt atatctaaaa aaaaaaaaaa a (2) INFORMATION FOR SEQ ID NO:61: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 2355 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:61: 1 cttccacctc ctgcgtgtcc atctgtgaga aggagccaga gcccaaggga gatgatggag 61 cctgaggagt acagagagag agggagagag atggtggatt acatctgcca gtacctgagc 121 actgtgcggg agagacgtgt gacgccagac gtgcagcctg gctacctgcg agcccagctg 181 cctgagagtg ctcctgagga ccccgacagc tgggacagca tctttgggga cattgaacga 241 atcatcatgc ctggggtggt acattggcag agcccccata tgcacgccta ctacccagcc 301 ctcacctctt ggccctccct gctaggagac atgctggctg atgccatcaa ctgcttggga 361 ttcacctggg catccagccc tgcgtgtaca gagctggaga tgaacgtcat ggactggttg 421 gcaaaaatgc tgggacttcc agagcacttc ttgcaccacc accccagcag ccagggcgga 481 ggcgtcctgc agagcacggt cagtgaatcc actttgattg ccctctggc agcaaggaag 541 aacaaaatcc tggaaatgaa aacgtctgag cccgatgctg atgagtcctg cctaaatgcc 601 cgactcgtgg cctatgcctc tgaccaggct cactcctctg tggaaaaggc tggtttgatt 661 tcccttgtga agatgaaatt tctgcctgtg gatgacaact tctcactccg aggggaagct 721 cttcagaagg ccatcgagga agacaagcag cggggcttgg tgcccgtctt tgtctgtgca 781 acactaggga ccactggggt ctgtgcattt gactgcctgt cagagctggg ccccatctgt 841 gcccgtgagg ggctgtggct ccacatcgat gctgcttatg caggcactgc cttcctgtgc 901 cccgagttcc gggggtttct gaaggggatt gagtatgccg actccttcac ctttaatcct 961 tccaagtgga tgatggtgca ttttgactgt actgggttct gggtcaagga caagtacaag 1021 ctgcagcaga ccttcagtgt gaatcccatc tacctcaggc atgccaactc aggcgtggcc 1081 accgacttca tgcactggca gatccccctg agccgacggt ttcgctctgt taaactctgg 1141 ttcgtgattc ggtccttcgg ggtgaagaat cttcaagcac atgtcagaca tggtactgaa 1201 atggctaaat attttgaatc tctggtcaga aacgaccctt cctttgaaat tcctgccaag 1261 aggcaccttg gcctggtggt ttttcgtcta aagggtccta attgtctcac agaaaatgtg 1321 ttaaaggaaa tagctaaagc cggccgtctc ttcctcatcc cggccactat ccaggacaag 1381 ttaatcatcc gtttcactgt gacatcccag tttaccacta gggatgaca cctgagagac 1441 tggaatctca ttcgagatgc tgccactctc atcctgagtc agcactgtac ttcccaaccc WO 00/09525 PCTUS99/17712 EPI-109 1221 1501 aaccctc; ttgggaaccc catctcccaa atcaggggtg ccagagccta ggcctgtgga 1561 acatccct agtctgzcag tggggcagga gatgatccag tccaggccag gaagatcatc 1621 aagcagcczc agcgtgtggg agccggtccc acgaaaaggg aaaatggcct ccatcttgaa 1681 acctgczag acccagttga tgactgcttt tcagaagagg ccccagatgc caccaagcac 1741 aaactgtcc ccttcctgtt cagttacttg tctgtgcaga ctaagaagaa gacggtgcgc 1801 tccctcagzz gcaacagtgt gccagtgagt gctcagaagc cactgcccac agaggcctct 1861 gtgaagaatg ggggctcctc cagggtcaga atcttttcca ggtttccaga agacatgatg 1921 atgctgaaua aaagtgcctt caaaaaactc atcaaattct acagcgtccc cagctttcct 1981 gaazgcacz ctcaatgtgg actccagctg ccctgttgcc ctctgcaggc catggtttag 2041 acacagggcz ttcagccaga gtctgaggat atacttcagg gactCtgtga acccctcaca 2101 attgtatgcc aactttgtgt gcttatgtgt acatgcattt ttcttggggc gagttcataa 2161 ttttaatcaa attctcatag gggttcatga cccacaatag gatacaaacg aagagtttaa 2221 gccagcaca tccagatggg ttcagcagtc tggtcagtga gaaagggccg agggtagaca 2281 ggcagctt t gtggttcagc tgtgacatg atatataaca cagaaataaa ttatgcttgt 2341 ccctgaaaca aaaaa (2) INFORMATION FOR SEQ ID NO:62: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 2396 base pairs (B) TYPE: nucleic acid (C) STRANDEONESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:62: agtgcgcagg actggcaaga gggaagccgg gctgctccac gcctttcacg ccttccacct 61 cctgcgtgtc catctgtgag aaggagccag agcccaaggg agatgatgga gcctgaggag 121 tacagagaea gagggagaga gatggtggat tacatctgcc agtaccigag cactgtgcgg 181 gagagacg g tgacgccaga cgtgcagcct ggctacctgc gagcccagct gcctgagagt 241 gctcctgagg accccgacag ctgggacagc atctttgggg acattgaacg aatcatcatg 301 cctggggtgg tacattggca gagcccccat atgcacgcct actacccagc cctcacctct 361 tggccctcc agctaggaga catgctggct gatgccatca actgcttggg attcacctgg 421 gcacccagcc ctgcgtgtac agagctggag agaacgtca tggactggtt ggcaaaaatg 481 ctgggacttc cagagcactt cttgcaccac caccccagca gccagggcgg aggcgtcctg 541 cagcagacgg tcagtgaatc cactttgatt gccctgctgg cagcaaggaa gaacaaaatc 601 ctggaaatga aaacgtctga gcccgatgct gatgagtcct gcctaaatgc ccgactcgtg 661 gcctatgcct ctgaccaggc tcactcctct gtggaaaagg ctggtttgat ttcccttgtg 721 aagatgaaat ttctgcctgt ggatgacaac ttctcactcc gaggggaagc tcttcagaag 781 gccatcgagg aagacaagca gcggggcttg gtgcccgtct ttgtctgtgc aacactaggg 841 accactgggg tctgtgcatt tgactgcctg tcagagctgg gccccatctg tgcccgtgag 901 gggctgtggc tccacatcga tgctgcttat gcaggcactg ccttcctgtg ccccgagttc 961 cgggggttsc tgaaggggat tgagtatgcc gactccttca cctttaatcc ttccaagtgg 1021 atgatggtgc attttgactq tactgggttc tgggtcaagg acaagtacaa gctgcagcag 1081 accctcagtg tgaatcccat ctacctcagg catgccaact caggcgtggc caccgacttc 1141 atgcactggc agatccccct gagccgacgg tttcgctctg ttaaactctg gttcgtgatt 1201 cggtccttcg gggtgaagaa tcttcaagca catgtcagac atggtactga aatggctaaa 1261 tattttgaat ctctggtcag aaacgaccct tcctttgaaa ttcctgccaa gaggcacctt 1321 ggcctggtgg tttttcgtct aaagggtcct aattgtctca cagaaaatgt gttaaaggaa 1381 atagctaaaa ctggccgtct cttcctcatc ccggccacta tccaggacaa gttaatcatc 1441 cgtttcactg tgacatccca gtttaccact agggatgaca tcctgagaga ctggaatctc 1501 attcgagatg ctgccactct catcctgagt cagcactgta cttcccaacc cagccctcgg 1561 gttgggaacc tcatctccca aatcaggggt gccagagcct gggcctgtgg aacgtccctt 1621 cagtctgtca gtggggcagg agatgatcca gtccaggcca ggaagatcat caagcagcct 1681 cagcgtgtgg gagccggtcc catgaaaagg gaaaatggcc tccatcttga aaccctgctg 1741 gacccagttg atgactgctt ttcagaagag gccccagatg ccaccaagca caagctgtcc 1801 tccttcctgt tcagttactt gtctgtgcag actaagaaga agacggtgcg ctccctcagt 1861 tgcaacagtg tgccagtgag tgctcagaag ccactgccca cagaggcctc tgtgaagaat 1921 gggggctcct ccagggtcag aatcttttcc aggtttccag aagacatgat gatgctgaag 1981 aaaagtgcct tcaaaaaact catcaaattc tacagcgtcc ccagctttcc tgaatgcagc 2041 tctcaatgtg gactccagct gccctgttgc cctctgcagg ccatggttta gacacagggc 2101 cttcagcaga gtctgaggat atacttcagg gactctgtga acccctcaca attgtatgcc 2161 aactttgtgt gcttatgtgt acatgcattt ttcttggggc gagttcataa ttttaatcaa 2221 attctcatag gggctcatga cccacaatag gatacaaacg aagagtttaa gccagcatga 2281 tccagatggg ttcatcagtc tggtcagtga gaaagggccg agggtagaca ggcagcttct 2341 gtggttcagc ttgtgacatg atatataaca cagaaataaa ttatgcttgt ccctga (2) INFORMATION FOR SEQ ID NO:63: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 40298 base pairs (B) TYPE: nucleic acid (C) STRA NDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:63: gtaagtatct tccctctgtg gctaggaaga caaggaatac atttttaaat gtctcctaaa 61 gcaaggaccz gaaaccagct ctatgggatt attcttgttc ctctttggtc aatgcagaga 121 catgggaaaa accaccaaag gtcatgaggg tctcttccag ggatccctgg acattgcctt 181 tcccagtggt gtgacaagag ttagaggtgg cctaccttgc ctcctgtcct aggaggcgac WO 00/09525 PCT/US99/17712 EPI-109 1222 241 agtaggagag ccttcggt:t :ctcatccc :racttgrat attgaacttt acttaatgca 301 ggctatatcc aaaatacagt atgaattaga cagaataga aatgctttct attctacctt 361 cagaaaagga aaagggtagg gtaggggaaa zeargggaga gattaaaggc agagaggaaa 421 cccagatggg actgtttaat ccccaagcaa aaaaccacta ggaaagagag ataccttccc 481 tctaactttt gtattcggtg cactgacatt gctctctgtg ctggtgggaa attgatttct 541 gtgccaggat gttctaggct gaggccaaga gggtgctggc cctttaccca gtggaagaaa 601 aaggcaaggg tgaggctttg tagactttcc cattcggagg taatgatgcc tccttcagcc 661 ccacttcttc aaactgactc cacctgctcc catctccaca cccctccgtt tctcatttag 721 ccaaagcaca tcatccttgc agcccaccac tcagcttggc caggtgcgag acatctttcc 781 ccacttcata cctcccctcc ggccaggtga tgtttgcctc ctcag 1 gatcacctga agtcaggagt tcgagaccag cctgaccaac atggagaaac cccgtctcta 61 ctaaaaatac aaaattagtt gggcatggtc gtgcatgcct gtaatcccag ctactcagga 121 ggctgaggca ggagtatcac ttgaacccag gagacggagg ttgcggtgag ccaaqaacat 181 gccattgcac tccagccttg gcaacaagag caaaactccg tctcaaagaa aaaaaaaatt 241 tttttttgtc aacccatgtg ggtatgaaat tgtttctcat tatttgcatt tcactaatta 301 ctagtgaggt caaacatttt ttccctcatt tcttatccat taaagtttat tctgtgaatt 361 gccagttcat ggccattttg ggggtgtagt ttttcttact gatttattga agtttaatgt 421 ttttctggaa actaatattt tgctagttgt gtgaattgta aatatcttct cccactgtat 481 ttttttaaaa actttttatt gtctgaatta gcacatattt agtgaatgcc tctatgtgca 541 attctttttt tttttttttt tttttttttg agatggagtt tcgctcttgt ttcccagact 601 ggagtgcagt ggcatgatct aagctcactg caaccttcac ctcccgggtt caagtgattc 661 tcctgcctca ggcctcctga gtagctggga ttacaggtgc ccgctaccat gaccagctaa 721 ttttttgtat ttttagtaga gacggggttt catcatgttg gccaggttgg tctcgaactc 781 ctgacctcag gtgatccacc cgcctcggcc ttccaaagtg tagggattac aggcatgagc 841 cagtgagctc agcctctatg tgcaattctt aatgtcaagc tgagggagaa gtctaagaag 901 ttttatataa gtctgacacc cagggtgcct gtaattaaag gtggaatgaa attttaattt 961 gcgagttgat ccttctgttt tttagttcag tacttccc tttttagaat gtatgctttc 1021 cagataatta gtgagataaa gatttgattt tcacttttag catttctaaa agctgtaata 1081 tgctacctaa cttgttttta attcttgctc taacttctga tattttatag ttgtgtattt 1141 tgaattatat tttaaaggat taagtggatt attgcacatg atatttagta aagtgtttgg 1201 gagcatttag cacagcctcc aaaaattaga attccactag ccccctgatc ctacatatct 1261 ggcatcttaa gagtcaataa tagcaaagtt gagagaggca gcttggtgtg gtggaaagaa 1321 catgggtatt ggatccgata gccttaggtt caaatcctgg cttcttcagt aattatcttc 1381 tgtaatttta gccaagtgtt taatttcctt gagactcagt ttctcgaaga tgaagtagaa 1441 aatggctttc accaggttgt tgtaaagact gaatcaaata gtgtgcatga aaattgcaag 1501 gcatagtgct caggacatag ttaacattct taaatatatg ttgaggaatg gtgtgcacct 1561 gaaaattcct ataaaagctg caaatataca tgccttttga tccagctgtt ccacttcagg 1621 atatccttac tcatgtgtgc aaagcaattt tttgtagaaa tgtttgtaat agcaaaagac 1681 tggaaacaac tgaaatgtac actgctaggg aactgattac tctctggtat gtccacgcaa 1741 tgcagctcta tgaaaaaaag gagtacgtgt caagatatat taacaaataa agtacagaat 1801 attgtactgt acttatccct tttgtgttta acaaaagaaa gaaaaggaga aaaattagaa 1861 tatagtatat atttgccttt atgtgcaaaa aaaggaaatc actttttgtt ttttttgaga 1921 cagggtctca ttctgtcacc caggctgggg tgcagtggcg ctatcacggc tcactgcaac 1981 ctcaacctcc caggctcaag cgatcctccc gccacagcct cccaagtagc tgggactaca 2041 ggcacacgcg ccatgcccag ctaatttatt tatttatttt tggtagagat ggggtttcgc 2101 gatgttaccc aggctggtct caaactcctg agttcaggtg atccacctgt cttggcctcc 2161 caaagtgctc tgggattaca ggcatgagcc actgtgcczg acctcttttc ttcttgatgt 2221 gaaattcttc atagattaga caaatttgcc cattgtgcaa atatgttgca aatatatttt 2281 ctcagtttgt catttatctt gatttttctt atggttttaa aaaaatgtga ttggatttat 2341 ggtttctggc attgaaccat agttataaat gtattcttta ctctgaggtt gtccagggaa 2401 tcttctaatt ttcttaattt aattttcatc ttttaaaaac agctctattg atgcataatt 2461 gatatacaaa aatagcatat atttactact atttgatgag tttggacatg tgtacacacc 2521 catgaagcca tcagttaacc tgatggtggt gatggtttcc tgtaatttta tgcttccatt 2581 tttcacattt agatctgact tttctggaat ttatctaagt gcacgatgtg aaagatagat 2641 acagcttatt tttctttcca gatggctata ccttgttcta ggacaattta ttaaatagtc 2701 catctttttc tttctgatct gagatgctat ctttattata tgctaaattt ctgtacatgt 2761 ttaaatttat ttgctccttt tgtttgtctc tttgtacacc agtatctacc tcattgttct 2821 aattattcga gcttcaggat acattttaat acttctgggt aggaacagaa ccttctcgtt 2881 actcttacaa aattttcttc tttattctgg tttatttttc ctaagaactt taaaagttgg 2941 cactgaattc caaaatagaa cacccaaaaa cctgttgatt tttccactgg gattatgtta 3001 aattttcggg ttaacttagg ggaaaaccat tatttcatga tgttaaatct tactccatga 3061 gagagcatgg tacgtctttt catctgtaca ggtctttttt tatattgttc agtagcaatt 3121 taaaaaaatc atccactatg ttcaatgaaa taaaaggcca gatttaaaaa tttggcaagg 3181 agttgaaaac tataaaaagg aaccaaataa aaattctttt tttgccccca taaggcagaa 3241 gaaatacaaa ttctacaact gaaaaaatat aatatctgat attaagaaat caataaatgg 3301 tttattatat tagctacatt tgaagagaca actaaaaaag aaaaatattt tcaaaccaac 3361 tcagaaacaa gaagatggaa aataaagaat acaatgctat ttatatttat atataatagt 3421 atatataata cacaagttta acataggact gcatttgcag aatagaagag agataatggg WO 00/09525 PCT/US99/17712 EPI-109 1223 3481 gagatacaa cacttggaga aaaaataacg aacactttt tatzaaagt gcctaactt 3541 gctgggtgzg gtggctgaca czgtaatcc caacacttzg ggaggctgag atgggtggar 3601 catttgaacc caggagttca aaaccaactt gggtaacatg gcgaaacccc atctctacag 3661 aaaaactcca agaaataaaa aacaataatc atctgagtgt ggtagcacat gcccgcgtcc 3721 ttgctactca ggaggtgggg gtggcagaat taccagggcc tagaagtcaa ggctgcaatg 3781 agctgtgatc gcatcactat acttcagcct ggttgacgag tgagaccctg tctcaacaaa 3841 taaaaataaa aataaaaata aaaatgccta acttggtgct tggcactttc taaaattgac 3901 acataatatt tgtacctgtt tatggagtat atgtgatatt ttgatacatg catacaatgt. 3961 gtgtaataa caaatcagga zttaagat atccatcatc tcaaacattt ttctttgtgt 4021 tcagaacatt ccaaatctag otattttgaa atatacaata aattattaac tatagtcatc 4081 ctaatgtgct attgaatatt attgaattcc atctaattat atgtttgtac caattaacca 4141 atctctactt attcctcacc cccagctccc accaaccctt tccagtctct ggtaactatc 4201 attttattct ctacctccat gagatcaaat tttttacctc ccatatcgtt gtcaatatta 4261 ttatttttcc caccctggct cctaatgaag gatttattga caatatcact ggaatctaaa 4321 tcctctaggc cattttttca ccaatgccct tattttctta gggctttttt ttttcttaaa 4381 tcaacagttt taatgagata taattcccat tctataaaat ttcctcgttt gaagtgtaca 4441 gtttaatagc ttttagtata tccacagaag tgtgcaacca tcaccataat aaattttaaa 4501 acattttcag cagggcgcag tggctcacgc ctgtaatccc agctactcag gaggctgagg 4561 caggagaatt gcttgaaccc aggaggcaga ggtttcagtg agccgagatt gcaccactgc 4621 aatccagcct gggccacaga gtgagactcc atctcaaaac aaaacaaaac aaagcaaaat 4681 aaaacaaagc aaaataaaac aaaaccaaaa cccaacaatt ttgaacattt tcatcttacc 4741 accctgccaa aaatccctgt tctccttagc catcaatctt cagctcccta cccacttcta 4801 accatgaatc tattttgtag atttgtctat tctcgatatt tcatatgaat gaaataatat 4861 aatatatggt tccttgtgac tagtttcttt cacttagtat gtttccaagt tcatccatgt 4921 tttggtatgt atcagtactt cattcctttt tatcatggaa taatattctg ttgtattgat 4981 atactacgtt tcattcattc atctgaacat ttggattatt tccatttttg tctattataa 5041 taattctgct atgaacaccc atgtatacgt ttttgtgtgg acatgatttc attttccttg 5101 gatatacacc tagcagtaga attgttgagt cataaagaac tctaggttta gctttctggg 5161 gagcttccag attattttcc aaaatggctg tgccatttta cattcccacc agtaaagtat 5221 gagggttcta atttttccct gtcttcacca atacttgttg ttatctatct tttttattat 5281 agtcatcata gtctgtatga agtgatttct cactgtagtt ttttcagtag taattaaaaa 5341 atttcctacc tattttagcc taaaattact ttcctgactc tcttcaagga gcctgccaga 5401 gaattctctc tctcgtgctg tctcccttat gcctgggcat aagctctgat aatgccctgt 5461 ctgggaaaac tcttttggcc ttctcaattt ctattacatt gagagcccaa gaacccatgg 5521 tcagtaacag gccaatgaga agcctcctgc attagtctag gtgaaggata atggtggctt 5581 ggaccggaat agggtggtag tcatggaaat ggggagaatt tgacagacta gatttatttt 5641 ggaaatagaa ctgaatctga acagattgaa ttgggcaggg agcagggaaa gtgaagggga 5701 aggaagacac caggtttatg ccttcagcat ttgggtggat gaatggatgg atgaaaggat 5761 agatggatgc atggatggtg gttggatgga tgagtggttg gatgaatgga cggtcaaggg 5821 gtgaatagat gggtggatgg aaaatggaga gatgatgaac tgagatgggg aagactagaa 5881 gtggggcata tttttgggga aagacagttt tgcaatacgt taagtttgag gtgcctcaga 5941 gtcataagag aggatttgtc agaaaggcag ttggatataa gattttgaag ctcaaaagac 6001 agggagggcc tgatggtatg tttaaaccta tacggatatc acataggtaa catttcaagc 6061 ctaagaaatg ggccgggcgc agtggctcac acctgtaatc ccagcacttt ggaaggctga 6121 ggcgggtgga tcacttgagg tcaggagttc gagacaaacc cagccaacat ggtgaaaccc 6181 catctctgct aaaaacacaa aaattagtgg ggcatggtgg cacatacctg taggcccagc 6241 tactcaggag gttgaggtgg gagaattgct tgaacccggg aggcagaggt tgcagtgagc 6301 caagattgcg ccactgcact ccagcctggg cgacagagca agactccgtc taaacaaaac 6361 aaaacaaaaa aagccttaga aatgggcaat gccaccaaag cagaaagatg aaaggagggc 6421 aatgccctga ggtgtgccag cattggagga aacaaacagc cagagatgta ggaggaaagc 6481 ccagagaaac tgtgagctgc aaggatgaag tagtaacaaa taaaatgcca ccaagagaac 6541 cagaaggacg actggaaaca aataaacaag aaagactatt gcatttagca acgtgaaaac 6601 gttggattac tttttactca gaaatcaaac cccaaggata gtgtttCCCC tccctacggg 6661 gtttctgcag gtccctttac acgccccctt ctacttcttt aagtgctaaa agtgattaat 6721 ttggggtgat gttttaattt ctattctttt tggcttataa ctgtgttttt tcattctttg 6781 caacaacaga tagtatgttg taatagaaaa atccattgtg gtcaatgata acttctgcct 6841 gttcctgggc acagggggca tcactattag tgcctgttcc tcctcccta ctgctgataa 6901 ggaaacaggg gcaggaataa tactaataat ttgtgctact ttttctgcat acccttggcc 6961 ttattctggt ctactgagct gggagcttgt ctgaggctgg agctctattg tctgaatcca 7021 ggggcagaaa gaactgaggg ctcttttacg gcatccacct ggaggctgcc tgcaggcttg 7081 ggttgctaag tgcactgctt aacttagaag cgccttttat cctggctctc ttgaccagtc 7141 aaagttgtgg tcgctgtttt ctacaaggac tggggaaaga aagggtggaa ttaattaaac 7201 ctggaggaag ggactttgaa gggcggagct aaggtcaaag aaagaaccct ttaaataaag 7261 ggcccacact ggctgccagg gagtgcgcag gactggcaag agggaaqccg ggctgctcca 7321 cgcctttcac gccttccacc tcctgcgtgt ccatctgtga gaaggagcca gagcccaagg 7381 gagatgatgg agcctgagga gtacagagag agaggtgagc aacgggcatc cctggccctc 7441 ttccctgctg ctactcctgc aggaacggct gctggtgggt ggcccttaaa ttgtggggtg 7501 acatttgatg ggagcattag aattgccttc tgagagttgg caccagcaac attttttttt WO 00/09525 PCT/US99/17712 EPI-109 1224 7561 cracgaaaaa aatgtgggat cagagtgtaa aacttttctc aaccacgtg tcattctccc 7621 tctcatatac ccactctcac atatgtccac actaccgtgc cttgct::tz ctccccactt 7681 tcccacaaaa ttgaggattt ggatccctga gccactagat gggaaaaagg gattgttcat 7741 attctgaaat agaaaaaaat tttctcaata ttctgtaatc actgcaaatc ctttctttct 7801 taacattcat tccttcatgt gtgaatctat cagcagtgtt ctttcattta gtcattcatt 7861 tcataaatat ttagtaggtg cctactctgt atcaggcaaa accaagtagt tatccagttc 7921 tcaggcatgg atctccctta gcaggaaagt aggtagttgc ttaaaaaaga atcttgaatg 7981 tctatttcta taatgtttta tatcctccta ctcactaatt agtgtgCgtt agcttattcc 8041 attgctttcc caaggcactq tcagctgaga gcaagttCct gtggatattt atcttctgag 8101 tggaacacaa atacatttag cactgttcct ggatcagtgg agggttaggt ctagagctct 8161 cagatctctg gtggggccct gctggagaag aaccaggatg tgagagggtt gaaggggagc 8221 agaaggaaga tagaatggtg tggaaatcta cctttgtctc ataagttttg tctggggttg 8281 gttctgttct taagaacttt gcataagctg atgcagaggg gagaaactga gtcccctctc 8341 ctaggtaaaa gcagcccagg gagtactaag gaatggatgt tgagacagac aaagagatat 8401 gtacacacac acacatgcac acacagcaac agaggcactg aagactgcaa tctgaaagaa 8461 taaataattt gcaatagttt cagagtgttc aacttgactt ttttttcctt ccttactcat 8521 atgttcattc acttgataca ttttttttta gcatctaaaa aatatcctaa gcactgaggt 8581 gttgatggag gcagcaggag ggagagaaaq tcattaagat ttggtgccac atttcccagg 8641 ccagggcagg gggcttggtc tggatccatg gttgtgcttt agggattctg tgagcctcag 8701 aaattataca caaagttctg tgtatatgta agcctacagt tttaatcaga ttcttgaatt 8761 aagtcctcat atgagtccaa aaaagatgaa taataactga ttcaatgggg atggtgaaaa 8821 aatagatttt tttgtccttt atcggaactg ggcatggaat ctttctatct gtgctaacag 8881 atataactgg tgggtgtgtg tgtaacaatt tttggataca aagagctata gagtttctat 8941 tgaacctata aaatagttaa tagatgttct gtttctgaga aggaaaaaaa ggtaggagag 9001 acaatcaaaa ttgaagtgga taaaggaagg ggaaagaaaa tgaaacgttt cactttggcg 9061 ctagagtttt gtgctttgga gattttcctt tttgttcatt tgctcactta gaaactccct 9121 ccatcattca ttcactccct cactcttttt ttaaattctg aagataaggt cgtgcagggg 9181 atcagatcct accctcggcc catgaatctg tctctctctt ttttttgagt ccaggctgga 9241 gtgcagtggc acgatctcgg ctcactgcaa cctccgtctc ccaggttcaa gcgattctcc 9301 tgcctcagcc tcccaagtag ctgggattac atgcgcctgc caccacgccc ggctaatttt 9361 ttgtattttt agtagagagg ggtttgacca tgttagtcag gatggtcttg atctcctgac 9421 ctcgtgatcc gcctgcctca gcctcccaaa gtgctgggat tacaggcatg agccactgtg 9481 cccggccaaa tccatctcct tctttaccaa gtctcttggc cggacctga gagggatggg 9541 cacaaatcgg tcaggcccag tcaggggatt tcagcctgat ttctctatgt cacttctagg 9601 gagagagatg gtggattaca tctgccagta cctgagcact gtgcgggaga gacgtgtgac 9661 gccagacgtg cagcctggct acctgcgagc ccaqctgcct gagagtgctc ctgaggaccc 9721 cgacagctgg gacagcatct ttggggacat tgaacgaatc atcatgcctg gggtgagaca 9781 cagtgaccac aagggcagtt ctggatttca gggcacagaa gggtgggtgg tggcctggag 9841 aaagacctgc tttgggtcag cttgggatga gaatgcatcc ttcagccact tggccaccaa 9901 caccccagcc catctgctag gcatgtggag ggcaggactt tgactggtat taggtttctt 9961 tttctttttt tttgcccagt tgtgccatgg catgaggttt ctgatgccag ggcagggctg 10021 gccagaacac ctgcattcca gagcacagcc tggcagaagt gtggaag-ct aatgggatgg 10081 gtggagaagt gaacattttg tctgagggga aaggacactg tgtatagtaa gacaggggag 10141 aggaagctgg tggtagtgcc tggccctgac gacggagcca gagactcttc tgtacagtgt 10201 ctgagaccac accaaagaga aggaaggaag tggggaacac atcctggcaa ggacacgctg 10261 gtgaccaggt tgcgttggcc caggaaactg agtgggccct ggcaacccct cctgtcccct 10321 ctgaggtctg gtgattgagc tgcttttcaa gagcaagaag ggactttzcc tgaatcattg 10381 atactttcca tgatggaggg tgcagcctgg gatagtgctg gtggggccag gaagctgatg 10441 gaagctggct gatgcatggg cttgagctgg agcctgcctt gatgggtggt ggacacccct 10501 gaccactggc ggtgaggagc tctgccatgg tgctcatgct aaagtggcat cgactccctt 10561 cctgtggcgg ggctccctgc catgtgccag ctctgtgctg gccacatgac atgctatcta 10621 atttaatctt cccagtggcc ctgttttaca gatgaggaaa ctgctgatgc tcagagaagt 10681 taactgtctt gcccaaagtc acagaattag tacztggtag atccaggatt ttaccctaga 10741 ccagtcttac ttcacaggct gtgccgtttc tcctaccccc tgtcacctct actggtgggt 10801 gcctgaatgt gcctggctaa gcctgggccc ctagcattgc ctgtctggct ccacaccccc 10861 acacaagctg tgtcttccct ctccctgctt ggggcatttg tgttctgaac cacacatgtt 10921 tagaggctct tcctgaggcc agcttgaggt ttgccttcat cattcccaaa gaacttttga 10981 cttcaatgtg acaaaaaggc caggcgcggg ggctcacacc tgtaatccca gcactttggg 11041 aggccaaggc aggtggatca cctgaggtcg ggagttcaag accagcctga ccaacatgga 11101 gaaaccccgt ctctactaaa aatacaaaat tagctgggca tggtggcaca tgcctgtaat 11161 cccagctact tgggaggctg aggtaggaga atcgcttgaa cccgggaggc ggaggttgcg 11221 gtgagctgag atagcgccgt tgcactccag cctgggcaac aagagcgaaa ctccatctca 11281 aaaaaaaaaa aaagtgacaa aaatatgcct agaggcaggg gtgggaaaat attcaaactc 11341 agaaagtgat ggcaattttg actttttttt tttttttttt ttgaagcaat agagacaagg 11401 tcttgctatg tcgcccaagc tggtctccaa ctcctgggct caagtgatcc tcctgcctcg 11461 gccttccaaa gtgttgggat gagaggccta agccactacg cctggccatg agggcaattt 11521 catacaaagc cactcatctc tttgaccatt cagcctattt cacaagcatt ttttgaaaat 11581 gtcaatatca gtaaggcttt acggaggcta gatcctgata agattatCtC ctggatttta WO 00/09525 PCT/US99/17712 EPI-109 1225 11641 ttc:ataaaa :ataatctac Lgaggggcza actgtaatct gggagtgaga ctgaaagcaa 11701 ctgzcaaaag aggtggaaat gagctgaztc a7ttgatcaa gaggaatrcc agcagttgct 11761 gtgggtatag zcggtgaggc tcatttc-;g aaagaggtct gtttgttttt gataagggct 11821 cttctggcta tttatctta tttatCttac aagaacagac tattgtctct tgatagagct 11881 aggaggtaga agcccttctc tggggtttcc aaaatactgt cactaaggac agtgataatg 11941 atggtcaaat ctctcaactc atctctcagg ccacaccagc ctctgagagc tggcctgaaa 12001 gcagttggcc ctttgcttac tcattttgct cagtgcctca ttgaaaactg aattagtttt 12061 tctcttcctg ccaccaccta gaaaataaga gaagaagaaa aactctcttt cccctttaat 12121 tccaaccctg gttagacaat cctcattac ttttCatgag agagagagag catccccacg 12181 ggaaaagtca ggacaccacc ctgctcgggt gtctgggctt ctgcctcatt gcggtcacct 12241 gtccctatgg ggtatgtgtg accacaggga tgtggcctct ctctgtcagc cccagttctc 12301 gcctgcaaaa cagagataat gtgtaggtcc taccccatag ggtcctgtga gaagtaagta 12361 agagaaggct tggagagcag gagatgtggt tattaccgat catgactctt acatggtgaa 12421 aattggagga agaggtttga ttctctgagt caagtcagga tatgtgatgt gtctgtcacc 12481 cacatgatta gtttaccgtt aatgttagag cttaacattt cacacatttc ttgcccacgc 12541 ctccacccac acaacaaccc taggagacag gatttatttt acgatgagaa actgaggttg 12601 agggaggtgc aggagaggct cctggtctta tggggtctgt actgtaaaca ctttttgaga 12661 cctccttttg aaaaacaaaa aagaaggagg ccggacacag tggtgcacgc ctgtaatccc 12721 agcactttgg gaggctgagg cgggtggatc atgaggtcag gagttcgaga ctagcctggc 12781 caacatagtg aaacactttc tctattaaaa atacaaaaaa ttagccaggc atggtggtgg 12841 gcacctgtaa tcccagctac ttgggaggct gaggcaggag aatctcttga acctgggagc 12901 caggggttgc actgagccaa gatggcgctg ctgcactcca gccctggtga cagtgcgaga 12961 atctgtctca aaaaaaaaaa aaaaagaatg aatctcaaaa gagacccaca caaatggtat 13021 gttggagctt aagttcatta gcttcatggt aaatctacac ggtcacacag ctggttaggg 13081 actgaggtgg gatgggaact tgtgtccttg gacttaattc ttaggctcct tatactatac 13141 acactgtcca ggacaaggtc cttgcccttg aaggactcta agtatgtgtg gacagtaaag 13201 aacaggatga tgccctaaga tgttatcaaa tgagtcctca gtagagtgaa acatctagaa 13261 ttctagagtt ctatcgctca gggaagggat cgaagggagc tgtgggagct gggggagagt 13321 tcgaggagga aatgaatatt tagcagCttt ctaagaactg gcaggttttg gaaggtcatg 13381 tctttataga gagtgccttt ctatcagggg acacagcatt gctcaaagac ataaatgcag 13441 aaaggaacag ggcatgcttc agagcagtga gatgaggaga gatgagataa tccatgaggc 13501 cgatgaacca ccagggctgc ttctgagttc tgatgggggg cccttcctgc ccactcagct 13561 cctccttaca tccggttttg attgtgggct cagggcttag cctggaggtc ggcctcccat 13621 acgcttggtc tgggctctcc tctctaccgt ctcctttcct cactacattc ccaatgtgat 13681 gcttaaggac agctttgaac ccattcaccc agaccctctg agttgcatgc tcagggagct 13741 cagtgctcca taaaacaaaa acaaaaggtg ccttttgcaa gaaactggat gaaacaagta 13801 gtctgctttt ctggagctca cagtctgccc ttcctttttt ttttttgaga cggagtcttg 13861 ctctgtcgcc caggctggag tgcagtggag cgatcttggc tcactgcaag ctcagcctcc 13921 cgggttcaca tcattctcct gcctcagcct cctgagtagc tgggactaca ggcttctgcc 13981 accccgcctg gctaattttt ttggtatttt tagtagagat ggggtttcac catgttagcc 14041 aggatggtct caatctcttg atctcgtgat ccacctgcct cggcctccca aagtgctggg 14101 attataggca tgagccaccg cacccggcct gcccttcctt ttattgctgg gcaggggcgg 14161 catgaggggt aagtactggg gactaatgtg aataccaccc agaatcccac aactgggtta 14221 ctgtagtgat tttccttttg catatttcct tctggacttt gcatatatga aaaggctcca 14281 ctgatgatct agcataggac atgggccaca ttagtgacaa gaacaccagt gaacaagtct 14341 gattttcatg gagttatgtc acttatttct gcttaaaagt gtcagcccat ctctagagtg 14401 acacttcacc ttgccagaga tggtctctgg agaaagaaag cctgctggaa atgcctcctg 14461 gtgccaactc tgtgcatgct ctgcctccag gtggtacatt ggcagagccc ccatatgcac 14521 gcctactacc cagccctcac ctcttggccc tccctgctag gagacatgct ggctgatgcc 14581 atcaactgct tgggattcac ctgggtgagt agcaacggct gtaactactc gcaatgggga 14641 acgtagcagg gagtggtatc ctagggcaga catattttgt cttggtttct gaatatggct 14701 ccacaataaa tattaatgag ggctatattc tttaagctta cgctttattt taattttctc 14761 atcacatcct ttaaccctat ggaatcacga gtattgatcc cattttgtag gtgaagaaat 14821 cgaggcttaa gcaacttatc tcccccagat cacacagctc atagagacac agataagact 14881 tggatacaga tctggttatt gccacagttt gtgaccttac ctaagcaatt tgatgcctat 14941 tgagtcacca cttcctctgt gctcttgtat ttgagtagct ggagatatgt cctaagactt 15001 cccttaataa ccccttaagc accactcagc tttaaatggt gccaaaagcc ttccagaaca 15061 tctttttatt ttaagcctga actcctatgg gtgtgtgggt gggtgggcgg gggtattcat 15121 atcttttcta ggaaaacatc cccctgggca tttgaggact tctcagctat gtattttagc 15181 gacttggaga accaaatcca agccaaccat ttctagggct gtttctccat agagccttgg 15241 agaattcgcc tcattgaggg cagcatgaat ccaaaacccc acattatttt ctcttttggt 15301 tgacagagag tggaccagga gagaggcacg tggcctaaca tgaccccttc tccagaaatg 15361 ttcccattga caccatcagg ggcagacatg tttctggagc tcgtgggggc acctcagtgc 15421 cctggggctg tgcagtttga agttcctttt cctttctcag gcatccagcc ctgcgtgtac 15481 agagctggag atgaacgtca tggactggct ggcaaaaatg ctgggacttc cagagcactt 15541 cttgcaccac caccccagca gccagggcgg aggcgtcctg caggtacctc ccttggcaaa 15601 gcttcaccta gcttgggggc taagtagcga aagacaagcc aaaccctaac ctggcaattc 15661 tcccgttctc catggagttt cccccacatt acccacaccg tcatcaccaa cagcaccatc WO 00/09525 PCT/US99/17712 EPI-109 1226 15721 atcacaactt cacctc:acc cccacctcag crtctgczzc attcacatgt actgctactt 15781 ccttgaaag aaattaaaaa gccaacacat gatcacartt ccagtatgac ttqattcaag 15841 tttcttagtc tataatczca caattccttt ttggtgtcc attttgtatc tcacggtaaa 15901 aggggaaagg agaaggcaaa gagaggactt ctctttczct ccctgctagg ttcaggagat 15961 ccccttgcag tgagaacaat taacagcata aactgazaa cggtatcctc tgaccctatc 16021 ttctggatac ttgtcaaacc atggttcttc aaatat'tct ttttttcaag agtagtgcca 16081 tggagtggag ctttctaagt gcctcccatg gaccacacac attgttaggt gcttttgcat 16141 ctataaatcc ttgacaztca tgagggcttg gttctaagac ctttgagatt cctcagattc 16201 ttgaattctt tttttaaata aaaatcgtgg ctggacatgg tgactcaccc tgtaatctca 16261 gcacattgag aggctgagac agatggatca cttagcccag gagttcaaac cagcctgggc 16321 aacatggtga aactgatctc tccaaacaaa caaaattagc tgggtgtggt ggcatgtgcc 16381 tgtagaccca gctacttagg atgctgaggt aggaggattg cttgagccca gaagattgag 16441 gctgcagtgg gctataattg tgccactgcc ctccagcctg ggcgacagtg taagaccttg 16501 tctcaaaaaa taaaaaaatt gccatgttgc tctgagatga gaaccaggaa gttcactagg 16561 tcctcttgct agctaagtga ctccctctct cactgcagcc ttgcagcaag attaaaatct 16621 gaacctcgga agaaagacaa attgcagcat gttgtggaca ttttggattg tcagcaaata 16681 gttacaactt cagatatcat atttgggaga acatgctaaa tgtctgcggt acatgatctt 16741 gcttttcatc tgattacc aggaaccctg caggtgaata gtaccattcc ccaatgtttt 16801 gagataagag cactgaagtt cagagagatt aaataatttg ccctagctta cacagctgat 16861 aagcagaaga acgaggattc aaactgatgc ctgtctaaat ccaaaccatg ctttctcctg 16921 tatcgtcagc catgtgaact tgagttagtc ccatcacctc tctgagcatc actctcctca 16981 tcttagtgtg acaagaatca taattatctc aaagaggtgt tgtgaggagc aagtagaatg 17041 ccagaaagtg ttttgtaaac tatgaattgc aatacagatg gaaggtgttg ttaccattat 17101 tattattttt aaaaacaggg cctggttctg tctcccaggc tggagtgcag tggagccatc 17161 atggctcact gcagcctcca tctcctgggc ccaagcaatc ctccaacctc agcctcccac 17221 gtagctggga ctacaggtgt gcaccactac acctggcttt ttgttttttg ttttttttgt 17281 agagacaggg tctcactatg ttgtccaggc tggtctcaaa ctcctggact caagggatcc 17341 tcccaaagtg ctgggattac aggtgcgagc cactgcaccc agctgattat tattattatt 17401 atgctacata cttctttaca taaatagctt tctttttatg gagtaactcc caggcactta 17461 atatctgtgg gatctggtcc acaccactct ccatgacagt gtctgccagg catttttagc 17521 aggattctat cagctgtagg tcacttgaag atttcaagaa gcaaagacat caaagactgg 17581 gtgaatgaat gataaggaac cataaagact cctgtgaagt tcctgaggtg gccccgaaga 17641 tttccacaat catggccaga gcaaaatcct acccaaccct tgtttggata atctatactc 17701 ccatcctggg aagcagttaa agggatgctc tccatttcat agacagaaaa gagtcttctg 17761 gaggggaaat gttagcccaa ggtcacaaga gctattgaca actaaatggg cccaagtcac 17821 cagcctctca cacaggccag gatcctctct tcctggggac tcaaactcca tatccatttg 17881 tgtaataagc tgagagttct tcttttaaat atgttttaca tggggagcaa acacatccag 17941 gagggacaga acattctctt tttggtttct gtggcctctg taatagagag gctggtatta 18001 ggtgcaaact tattttagaa ggcagaatag gaatgaaagt tggggaggga catgggcacc 18061 ctgggcagga ggagctgtgt atttccttct gtgaatagct atgacacaca catacacaaa 18121 cacatacaca cacagagaga gagagagaga gagagagaga gagagagaga gaaaaaacta 18181 gaaagcctgg ggaaatttgg caagagaata cagaaaggct gccatgataa tccttttccc 18241 ctgcagagca cggtcagtga atccactttg attgccctgc tggcagcaag gaagaacaaa 18301 atcctggaaa tqaaaacgtc tgagcccgat gctgatgagt cctgcctaaa tgcccgactc 18361 gtggcctatg cctctgacca ggtgagttgc ccgacgcagg acagcccttc gggttggtgc 18421 ttggcttctg gaatcttggt ccttgagcaa tttttttcta gacgtgagta cgctggggtt 18481 ctgagcagct cagacatggg agcttgtctc cagcaactgt agggaagaca agcttccaat 18541 gatcatattt ggttcccgag tcttaggctt cagcagtttc tggggggtga tcattccagg 18601 atgactcttt gctgacaggt ttctgtggcc cttctaggct cactcctctg tggaaaaggc 18661 tggtttgatt tcccttgtga agatgaaatt tctgcctgtg gatgacaact tctcactccg 18721 aggggaagct cttcagaagg ccatcgagga agacaagcag cggggcttgg tgcccgtctt 18781 tgtaagtcag gatatatgcc taagcttaga atgatagaac ttggatgtga ggaaggaatt 18841 ttggcagaat tcaggtaagt aacatgctgc acacaaaagc agaaaggtcc tcccatacag 18901 tattttacac atcatgaggt gctatccata ggtgtgttat ggaataaatt ttgtgggtca 18961 taaccagcat taaaaagaaa tatagtataa aatattagag tgcacacata tagccagagt 19021 atgtattgtt ttatgaaact tttttttcaa atacacacgt atacatgtac tagattgtta 19081 tataaaatgt gtttcttacg agccatggta aaacacagtc tgaaatatac actgttctgg 19141 tgggatggat gggagtagat cacgtctgtg gtgaaatctt tctcaggcca aatgtgtcac 19201 acgagcccac cctcctgtgt taacttgcct taattttccc ctaggtctgt gcaacactag 19261 ggaccactgg ggtctgtgca tttgactgcc tgtcagagct gggccccatc tgtaagtatc 19321 ttccctctgt ggctaggaag acaaggaata catttttaaa tgtctcctaa agcaaggacc 19381 tgaaaccagc tctatgggat tattcttgtt cctctttggt caatgcagag acatgggaag 19441 aaccaccaaa ggtcatgagg gtctcttcca gggatccctg gacattgcct ttcccagtgg 19501 tgtgacaaga gttagaggtg gcctaccttg cctcctgtcc taggaggcga cagtaggaga 19561 gccttcggtt ttctcatcct cttacttgta tgttgaactt tacttaatgc aggctatatc 19621 caaaactacag agtgaattag gctagaatag aaatgctttc tattcacct tcagaaaagg 19681 aaaagggag ggaaggggaa atcatgggag agattaaagg cagagaggaa acccagatgg 19741 gactgttaa tccccaagca agaaaccact aggaaagaga gataccttcc ctctaacttt WO 00/09525 PCT/US99/17712 EPI-109 1227 19801 tgtattcagt gcactgacag tczctctctgt gctggtggga aatcratttc tgtgccaga 19861 tgttctaggc tgaggccaaa agggtgctgg ccctttaccc agtggaagaa aaaggcaagg 19921 gtgaggcttt gtagactttc ccattcggag gtaatgatgc ctccttcagc cccacttctt 19981 caaactgact ccacctgctc ccatctccac acccctccgt ttctcattta gccaaagcac 20041 atcatccttg cagcccacca ctcagcttgg ccaggtgcga gacatctttc cccacttcat 20101 acctcccctc cggccaggtg atgtttgcct cctcaggtgc ccgtgagggg ctgtggctcc 20161 acatcgatgc tgcttatgca ggcactgcct tcctgtgccc cgagttccgg gggtttctga 20221 aggggattga gtatgccgac tccttcacct ttaatccttc caagtggatg atggtgcatt 20281 ttgactgtac tgggttctag tgagtgtagc agcccagctc cgagcacaca ggaacgcctt 20341 gcctcctctg gagagacctc agccactaat gcccatttgg aaacccacag ggtcaaggac 20401 aagtacaagc tgcagcagac cttcagtgtg aatcccatct acctcaagca tgccaactca 20461 ggcgtggcca ccgacttcat ggtgagtggc cagggacggg caacctggtg ggctcgggtg 20521 gccagtggga actgtaggcg tctgaccccc caaaatctgt acggtggctc ccttcagaag 20581 gcagcacact atgagctcat ctcataatac tgccaatgca taccttggtt tctaattgtg 20641 cctaagtata tagaatgaaa cccagaaaat ggttaaaaac cctagaaaat gagaccagcc 20701 tttgaggcaq tgtgcacatt tcctgaatat ttgtggcatt ttttaattcc cagaaatgct 20761 cttcctacca caggtggacc agttccttct gcctccatct cgggtcatct tttttgtttc 20821 ttacccagca gcagggcagg gtggagaatt tccctggtgg ggaaagagct ttcttgctga 20881 aatcgctttt gtttttttgt ccctgacaga ggcgctgtgq ggcagctctg tggtagtgat 20941 gggctgcagg acttgtgtga ggttctggaa gcctccaagc attcctgact ttcccaactg 21001 actgcgcctc aactctctaa ctcactctct ctctcttttc ttttgttttc tttctttctt 21061 tctttctttt tttttttctg agacagagtc tcgctctgtc aaccaggctg gagagcagtg 21121 gcgcatcttg gctcactgca acctccgcct tccaggttca agcgattctc ctgcctcagc 21181 tttccaagta tctgggacta caggcgtgag ccaccgcgcc cagcaaacct caactctctt 21241 gattccacat cctcagccag tattttgcct gagggaaacg agttcttaac aaattgactc 21301 cgcagtttga ggatgagccc ttcctttact tgtaggggag acagggatgt aaacgaatgt 21361 attacacata acctggccaa cggaggcagc agagcagagt gggggcaagc ttggtttgga 21421 attccattcc agcaqtggcc ctttgggaaa ctaactggac ctctctgaqc cttgctttcc 21481 ttatctgtaa aatgagaata gtggcattga ttcatagggt attgtgaagc ttaaatggga 21541 acacgtgtgg atcacctagc aaaatagccg tgtggcaagt gctcaatata tggtaggcat 21601 agtatttctg aaagctcttc tttgaagctg cagagatttg ttaggacagt ggttaggcat 21661 gtaggtgcta aagccagatg gcatgtgttg gagtcctggc tttctgttta ctaacttgtg 21721 tgacctcggg caagtgactt aaactctgtg tccagatttc ctcttgtgtc aaatgaggct 21781 gatgaccaca gttctggctt cttaggcttg ctgtgaggat tatacaaatt aatacactga 21841 agtgctgaga gcagtgtctg acccctgtaa gcatccttcc ttgtgaagag atggttttat 21901 cttatcttct tggacaactg aagtgtcttg cccttttagt cttaaaataa tagcttcgtc 21961 atcacttgat tatactggct attctccctt ggaccagtcc acaccctctt tagatatttg 22021 aagcttttgg attagaattg cagcggtaag cctcacggct tactggtggt gacagaagac 22081 cctctagagg taaagaaaga aagaaaaata atggttcttt atctccactg ctctttctgg 22141 taggttttca gagattttta atgaaaaatt aaaaaaattc cagaacagcc caagggtcag 22201 atatctttag ggataactgt aggtttgctt cctgagtgtg aattgatgcc cattctccta 22261 tgagtgtatt tgggtcatca taactgagga gcattatatt cacccttgcc cttttgaatt 22321 tcatgttacc gtttaaattc atttaccaca gtgcctcagg atcttcccgg ggttcattcc 22381 taggagtttg gagattttac agtgctctct gtcttccaga taactcataa aaatgttaga 22441 gtaaactctt cccagccctg ctctggggaa ccttattatt tttacctctc cacccagaag 22501 gcactgcctt acacttaccc ttcccccacc tttaatccta tggatttgat tttcaagtcc 22561 atgaagaaac tcctagaaaa gtgaagttgc tatctttttc atgatcctga gggtcctcag 22621 agctactctc acctgggccc aatgtctttc ccacccaggt ggctgcagct ttgaacagaa 22681 gctcagtcct gctctgagat gagccagaaa cagggcagca tcccaggaga gaagacttag 22741 gtgcttaacc cctggggtcc tggaatcacc taaaatcagg gctagattct ctgacagcgg 22801 agaagctccc tgttttctgc ctctcactgg acagagagca ccagtggagg gagcgttacc 22861 ttagccttgg caagggagcc ctgcaaggac cttacaagga cacagaggag gctggagatg 22921 cctcaaggta aagaagagcc ctgtcaggct ttatacgtcc agattttttg atccaacaga 22981 aaatgttggc tagaaccact ctgctgagtc agcatggatc agttttggaa tagtgacaag 23041 aaaaggagca actgggaata aggaagattg tgaagaaatc aaaataaaat cacctctgcc 23101 tatcctggtt tatttgctgg taaaataaag tagctctctc tatatatgaa ataaattggc 23161 tataactatc tggaaaccag aaccttttga cagatgatcc ctatcatccg ttcattattc 23221 tcttggagtg tccattggac aagaggtgga gttgacactt tccttgttac agcaattttg 23281 ttccattttc aggttttgat gccttctgct ggcacaaaag cccccaagct gctccccagc 23341 acaacagagt tttgcttgga aatcaaaggc ttagtagttt tctgctgggg aaacattgtc 23401 catcaacaaa ggggtaacat cccaactgtg cctggctcag gaaactgggg tgaagggtga 23461 aggtgaggac atttgtgagg atttgataat cttgtgtatg ggcagataaa tacgcagtgg 23521 gacaaacatt tatttttagt caacagaaat tgtggtagaa actttctgac gtttgaggga 23581 gatgtcatta ggaaaccacg tgactcatta gaataactgt aaatgttttc caaatcctct 23641 gctctatttt cagatctgag aaatcagtct gaaattgatt tggaaatttt cagatgtatg 23701 gtgactgcaa ccttgaactt taagctctgt tgaatttggc caccaggagc aaagagtcaa 23761 ttttcatcta acagcggcag aaatttgggt gctcatttga aatctgacag ctggagtgat 23821 ggctctcaga tcacaggaat ctcacaggaa aatgaacaag gcagtgtaag gttaaatagg WO 00/09525 PCT/US99/17712 EPI-109 1228 23881 ggtcatctg gctctagaca gaaatactac tgtgatttgt agctcacat: ttaaaataat 23941 ctaaatagcc aacacctact gacaacrtct tctgaggctc ttggcgtzt ttgtcctcac 24001 accacttgcc cgggaggtgc aattggttct ttatgtcccg gactgatgag ccagtgaggt 24061 ggcactaccc aaggtcacac agctagtaag tggcacagct ggaggcgaaa cctaggtctg 24121 cagggctcta gtgtctgtgc tctaactacc atactttaca ttttgggagg aataaaaata 24181 gaactttatt ttctgctatt caaqgaatat agattcattt agagtaaaaa tgtatttccc 24241 ttatgttgag tttctgggcc gggatgaaat gtttaaagca gcacttgaaa gcaaagtgcc 24301 cttctcattg gttcagggta atggacttga cttccacttg tctggctctc agacaagtga 24361 ctattggcca ccttcatcag tgatttggtc acacgatggg gcaacccttg gggagcttgg 24421 cttactcctt agcaacagct cccagagtca tggtgacatc gtccatccct ggagggctgg 24481 gcaggcaaca gataatgccc agaaatgccc gagggagtgg ggcacccttg tctctaacct 24541 tgggcactgt gttcctttgt ttctagcact ggcagatccc cctgagccga Cggtttcgct 24601 ctgttaaact ctggttcgtg attcggtcct tcggggtgaa gaatcttcaa gcacatgtca 24661 gacatgtatg tagcatgctg ctgtgggggc tgagcctgtg ttcctctgtt ttctcatggc 24721 gaggaaggct ggtttctact ttgcagatct gcctaggaga cttgcggtgt gtggttcagg 24781 tgtctgggcc tgttcctcag ctcctgggac ttgattctct ttgttaacca gaggagcgct 24841 gagcacaaca tgccctgagg gctgcctgat gcctgtcctc tgctgagtgt ctcaccgttc 24901 cccttgctgt cactgagcac tggggagggt tggccccaga gtctggtttg caggaaagag 24961 aaagagaaag taaatcaagg ggaagtgtgt gtggccaggg taggatccta tctgctttgg 25021 aattacctca atggtcacag ctggctgaat acttttagca ctattatgat tatgcctgaa 25081 ataaagctcc cctggccttg gacaggtaga cctaccaagt ctggaacaaa cctccctgca 25141 tcaacaggca tttattgaag gcctattttg cttaatttat ttctattcaa ttcaacaatt 25201 acaaggtatt gtgctaagaa agggacacag aggtaaatga gacaggtgca gcctctctcc 25261 catgttcttc atggaagaag cgggacttaa ctaagaactc tggccactgg cattgttctc 25321 ccacttctac aagagtccac atgcaagaca aagccattga taaaagtagt gggggaagct 25381 gaagacactg tcctttctgc ctatgtgtgt ctttgtcctt ccacctttcc tctagggaat 25441 tccttcttgg ttaaacaaac acaaaccaaa atgaagtggt ggaagcggta actatgattt 25501 tttttaacat ttaaaaaaaa taattattat gcttacataa taattacgta tatatttatg 25561 gggtatgtgt gaggttttga tacaggcata caatgtgcaa tgatcaaatt agggtaactg 25621 ggtatccacc actcaaccat ttatcatttc tttgtgttag aaacattcta gttccattct 25681 ttaagttagt ttgaaatgta cagcaaatta tagttaacta tagttgcctt attgtgccgc 25741 ctaacattag atctatttaa ttgtattttt gcgcccgtta actatcacct ctttatcccc 25801 cattccctgc tacccttccc agcctctgcc aaccatcatt ctactgtgcg tctccacgag 25861 ctcagtttgc ttacttttta actcccacgt ttqagtgaga acatgtgaaa tttgtccttc 25921 tgtgcctggc ttattttgct taacataatg ttctccagtt tcctatgact ggttttaatg 25981 ttggtaattt tacctttgta atcaccactg gttgtttacc aatgagcagc tgccaccaac 26041 aatattgagg aactttaggc actttgtgct gtttctagaa atgcagactc aagactggag 26101 ggttgtgggc ggggaatggt tggtggaggt tacaagtaat taggaacatt tttttgctta 26161 cagtttggga ctggatattc aatgtgcaga tcctgactaa cctcccttag cacttctgtt 26221 tgcaaatcaa acccctgaat tcctcctatt agcaacccca ttgcctacca tatgaggccc 26281 acactcctgg gcctggcttt caaggacttg acgattagct cctaccttag cttgggcatt 26341 tcatcgaccc atccagacct catgctcagt ccatctctgc accttcaccc gtgtccttca 26401 cctgaactac cctctcctct ccaaatgttg tgaatggatt aaattctgct tccactagaa 26461 gcttttctgc ctattccatc tgttctggtt tctgcttcat tagcattcct gtgatcacct 26521 actcaaacac ctttacaaaa ctgtgctcaa agttcttcca atgtcccaca atagaagaaa 26581 tggaattaaa ataaagttgt ttgatatgat ttgattttat ctcttcaact tgacggtgat 26641 gataattatt gacacttgcg taatgccttc aatacaaaaa taaattctag ttcttcatta 26701 gatccttagc acagtgcctg gggtggtcac tctaacctgg caaggctcag agggagtaat 26761 tgccctgctt gagggaagaa ggcccgggac tttccctgaa gcctcccaat tccaaatcct 26821 ttcttcatag ttctgggctg ctttctacta cactgagctc ttggaaagtt atataaaatt 26881 aaatttcata tttctgtgtt acagagaagt gctttaaaga atggattttt agttctaccc 26941 tttacctgtt tgatgacctt agacaaatta cttaaccttt ctatatttgt ctgccttatt 27001 tatttattgt tatttatttt tgagatgcag gtctctgctt gctcaggctg aagtgcggta 27061 gtgccatcag agctcactgc agccttgacc tccccaggct caggtgatcc tcccacctca 27121 gcctcctgag tagctgggac tacaggcgca taccatcatg cctggctact ttttgtattt 27181 tttgtagaga tggggttttg tcatgttgcc caggttgttc tcacgctcct gggctcaagc 27241 aatctgccta ccttggcctc ccaaagtgcg aggattacag gcatgagcca ccacccctgg 27301 ccatgccttc ctaatttata aaaatgagaa aaggatacta cctctctcaa attaaatgag 27361 ataatatata tgcagccctt agcacagggt ctacctacta ctcagttaag tactcaatga 27421 gtacctcttc ctcttctctt cttccccttc ttcatcatct ccttcttcat ctaattataa 27481 taaattgtca tcatcatcac catcatcatc atcatcatcc tcatctccta tcacctacaa 27541 tagggattgg taaacatttc ctgtaaaaag ccagatacta aatacttttg gctttgtggg 27601 ccatactcta ttgtaattac ctctgtacta caagagctac cgtagacaat atgtaaacaa 27661 atgggaatgc tgtgttccaa aaaactttac aaacacaggt gggggctata tttggccatg 27721 gctgcactgt gcctgccctt gacctagagc ggtgcagggc actggcagca gctctgcttt 27781 catgacctgt aaagtggggc tttggaggtg gcagtgctgc ctgtgctctg tattctcctc 27841 tcccctgacc tctgcttctg ttattgcaaa cagcatgtgt tgtaggaggg ataaaagcac 27901 agtgggagga gatctaccta ctgtcacttg taccttggga aagtCacttt cccttggttc WO 00/09525 PCT/US99/17712 EPI-109 1229 27961 cttctaaaaa atggaaaaat tgagctgaac acaggggcac gtgtctgtag tcccagctac 28021 ttagaggct gaggtaggaa gctcaatcgc tcccaccata gcccaggtgg gagttctggg 28081 ctatggtgzg ctatgccaat tgagtgtccc cactaagttc ggcatcaaca tggtgacctc 28141 ccaggagcaa gggatcacca ggttgcctaa ggaggggtga aggggcccag gttagaaatg 28201 gagcaggtca aaactcctgt gctgtttgaa actgaccacg caggggagaa aggggctcig 28261 agaaagatrt ggagaaactc atttcattat ggtcaaaaga caggctcagg gccagacatg 28321 gcggctcatg ccagtaatcc cagtactttu ggaggcctag gaaggaggat cgcttaagcc 28381 caggagtttg ataccagagt gaacaaccta gtgagaccac tgtctttaca aaaaaattaa 28441 aaaatgtagc tgggcatagt ggtgcatgtc tgtagtccta gctactcagg aggtgaaggt 28501 gggaggatta cttgagctca ggagttcaag gctgcagtga gctttgattg tgcaacatgc 28561 ctctgtactc tagcctatgt gacaaagcaa gaccctatct ctcaaaaaaa aaaaaaaaaa 28621 aaaaaaaaag aggttcagct aactcccttg ccctctcttg aaatagagca gtaagtatga 28681 gaactaactg atagaattac ttagcaaata tttttattga gatcttctgg atgcttggag 28741 aaatttttaa aaagaaaaga gaaggcaagt cctgtccttg tttagttagt aatcctgggt 28801 taaaaacaaa aagcaaaaaa ccccaggaca cttaaaaaga tggtatgaac ttcagtggaa 28861 gattaatata atacaaagcc tttaacattt taaaatgtaa caaaatattc ataccataa 28921 atgtaccatt ttactcattt ttaagtgtac aattcagtgg cattaagaat actcacaatg 28981 tggtgtgacc atcaccatta tttccagaat tttttcatca tcccgagcag aaactctgta 29041 tccattaacc aggtccaaaa cctttccatg atgggtggag acaagatgtg aaaatatgtt 29101 ctctatggaa tgtcagaaac aggggatgaa aagggcattt ggggtacagg gtgagaagag 29161 gtttgagagg caagtgaagc atgtaggctt aggatggggc agggccgcca ctagcccata 29221 tggcaacttg atgtgcacta caaacaggca tctcttcctt taggcacacg cagctcgcat 29281 gaggcacctg gctgggaacg cagagcatgg actgggtttt ggccctcact tgcccacttg 29341 gccagtcaag gagctgtgaa atcaggagtt gaggccgggt tgcctggact gcaaagcaca 29401 tgccttctgg gttctggggc tgagttgaaa gagggccctg agatgagttc tcgaggtgga 29461 tcccatgtga caggaaacag ggcgccattg gaaattttcc agcttggaat atgagcaaaa 29521 tcaaatggag atgacaatga ggcagaagcc gcttacaacg gctgtgacgg gaagatggcc 29581 ctggtttaaa accatttagc agtctgaaag tttatgcata gtctcttgtc tgatgattaa 29641 tctcagttct ctttatactt gcaattccag ggtactgaaa tggctaaata ttttgaatct 29701 ctggtcagaa acgacccttc ctttgaaatt cctgccaaga ggcaccttgg cctggtggtt 29761 tttcgtctaa aggtaatacc atcttccaag cccctctgtg aatgatgtct tgtggtgctc 29821 cagagcctct cggaaacaca aactgggctc tggggatgct gacagggggt gcgatggaga 29881 cttcacttcc tttatttttc aaacagggtc ctaattgtct cacagaaaat gtgttaaagg 29941 aaatagctaa agctggccgt ctcttcctca tcccggccac tatccaggac aagttaatca 30001 tccgtttcac tgtgacatcc cagtttacca ctagggatga catcctgaga gactggaatc 30061 tcattcgaga tgctgccact ctcatcctga gtcagcactg tacttcccaa cccagccctc 30121 gggttgggaa cctcatctcc caaatcaggg gtgccagagc ctgggcctgt ggaacgtccc 30181 ttcagtctgt cagtggggca ggagatgatc cagtccaggc caggaagatc atcaagcagc 30241 ctcagcgtgt gggagccggt cccatgaaaa gggaaaatgg cctccatctt gaaaccctgc 30301 tggacccagt tgatgactgc ttttcagaag aggccccaga tgccaccaag cacaagctgt 30361 cctccttcct gttcagttac ttgtctgtgc agactaagaa gaagacggtg cgctccctca 30421 gttgcaacag tgtgccagtg agtgctcaga agccactgcc cacagaggcc tctgtgaaa 30481 atgggggctc ctccagggtc agaatctttt ccaggtttcc agaagacatg atgatgctga 30541 agaaaagtgc cttcaaaaaa ctcatcaaat tctacagcgt ccccagcttt cctgaatgca 30601 gctctcaatg tggactccag ctgccctgtt gccctctgca ggccatggtt tagacacagg 30661 gccttcagcc agagtctgag gatatacttc agggactctg tgaacccctc acaattgtat 30721 gccaactttg tgtgcttatg tgtacatgca tttttcttgg ggcgagttca taattttaat 30781 caaattctca taggggcttc atgacccaca ataggataca aacgaagagt ttaagccagc 30841 atgatccaga tgggttcagc agtctggtca gtgagaaagg gccgagggta gacaggcagc 30901 ttctgtggtt cagcttgtga catgatatat aacacagaaa taaattatgc ttgtccctga 30961 aacaaaacat accctgtgtc acttaattgg ctgctgaaac attgattaac cagtctggga 31021 gcttaaacat atgtactttt tttgaagcat caattatgag tcaggcactg tggctcatgg 31081 ttcataaatg aggaaaccaa cgtttaggtc acacagcttt aaataggcaa acccaggtct 31141 cctgcttcca gtgaagccca ggctgtttcc accatgcagt actgctcaag gttggacctg 31201 aacaggagct cacagcccag caggctgctg gtcctccagt acatttaaat gtttcctttc 31261 taggtttgga acttgtgcat tttcccctta ttttcctgga cccggtagtc aaataaaagc 31321 tatgctcaca agtggcttgc ccataattag ttcagaggcc aaacacataa ttttatttcc 31381 atttcagatg gtactttgat aggttgtgac tctgaaatgg gttatgtaaa gagtattaaa 31441 gacaaacaaa gctgggcatt agttagaact ttaaggatag atgttaaaca gtaatatact 31501 atcacaatag ggaaaagggt cccatgtgaa ctgaactcaa cttggatttg tgcaaaggtg 31561 actaggcatt tcacagcgtg aatgggagaa tagggagaag gccagcctag acttagaaga 31621 gtcaggaatg tgaaaaatta caaaaagcgg aaagtggttg atgtgaaacc cctctgggtt 31681 tgctaactgg tgctttttga agtaagactc ttaccctccc acagagactg ggagtcaggg 31741 ccctgtgttc aggggttcgc tggaacaaac agttaattct ttcggcagct ttgagttttc 31801 ttaagcaggc actttaaggt gagctaggat caacttaggg atgtggcctt gagctgtgag 31861 aaactgtgtt agtgtttgtt caagtcttta taggcaaagg ttgaggccta gttgagaagg 31921 gggctcggag gagcttagct agagtttggt cgagaaaaga atctttgtta agagtttaaa 31981 gctttttttt tttttttttt tttttttctt ttgagactag tgctttctct ctttcccagg WO 00/09525 PCT/US99/17712 EPI-109 1230 32041 ctggagtgca gaggcacaa: catgtcttac zgcagcc:ca acrtcctggg cttgagcaat 32101 cctcctactt cagcctccca aatagctatt tatttt:gag atggggtctc attctgtgag 32161 tgcagtggtt ggaacacagt zcactgcagc ctcagccztz gaggctcaag ctgtctttcc 32221 acctcagtcc cacgagtagc tgggactatg agtgcacacc actatgcctg gctaattttt 32281 ataacttttt acagagacag ggtctccctg tgttgcccag gctggtctgg aactcctggg 32341 ctcaggtgat c 1 cgactaagaa gccctgttga cagctgcctt ccagcctcct ctgtctgtct gccaggagga 61 gcaatccaag ggagataa gagccctgtg aataccazga ataccgtgaa tactaccgag 121 ctagagggaa agagatggg gattacatct cccagtacct gagcactgtg cgggagaggc 181 aggtgactcc aaatgtgcag cctggatacc tgcgagccca gctacctgcg agtgctcccg 241 aggaacccga cagctgggac agcatctttg gggacatzaa acgagtcatc atgcctgggg 301 tggttcactg gcagagcccc cacatgcacg cctactatcc tgctcttacc tcatggccat 361 ccctgctagg agacatgcrg gccgatgcca ttaactgctt aggattcacg tgggcatcta 421 gcccagcttg cacagagctg gagatgaaca tcatggactg gctggcgaag atgctggggc 481 tcccggagta cttcctgcac caccatccca gcagccgagg gggaggtgtc ttacagagca 541 ctgtcagcga atccacttta attgccctgc tggcagcaag aaagaacaaa atcctagcaa 601 tgacagcgtg cgaqcccgat gctaacgagt cctccctgaa cgctcgtctc gttgcctaca 661 cctctgatca ggctcactct tcagtggaga aggctggctt gatttcCCtt gtgaagatca 721 gatttctacc tgtggacgac aacttctcac tccgaggaga agctctccag aaagctattg 781 aggaagacaa gcaacagggc ttggtgcctg tgtttgtctg tgcaacgtta gggactactg 841 gagtctgtgc atttgacagg ctgtcagaac tggggcccat ctgtgccagt gagggactgt 901 ggctccacgt cgatgctgct tatgcaggca cggcctttct gtgccctgag ctccgagggt 961 tcctggaggg catcgagtac gccgactcct tcacctttaa cccttccaag tggatgatgg 1021 tacactttga ctgtactgga ttctgggtca aggacaagta caagctgcag cagaccttta 1081 gtgtgaaccc catctacctc cgacatgcca actctggtgc agccacggac ttcatgcatt 1141 ggcagatccc cttgagccgg cgctttcgct ccattaagct gtggtttgtg attcggtcct 1201 tcggggtgaa gaatcttcaa gcacatgtca gacacggCac agaaatggct aaatactttg 1261 aatctctggt cagaagcgac ccttccttcg aaattcctgc taagaggcac cttggtttgg 1321 tggttttccg tctgaagggt cctaattgtc tcacagaaag tgtgttaaag gaaatagcca 1381 aagctggcca gctctttctc atcccggcta ctatccaaga caagctgatc atccgtttca 1441 ctgtgacgtc ccagtttacc accaaggagg acatcctgag agattggcac ctcatccaag 1501 aggctgctaa ccttgtcctg agccagcact gcacttccca gccgagccct cgggccaaga 1561 acgtcatccc gccaccgcca gggaccagag ggctatccct ggagtcagtc agcgagggag 1621 gagatgaccc agcacaggcc cggaagatca tcaagcagcc aggagccagt ctggcgagaa 1681 gggaaggcgg ctctgatctg gaaacgatgc cggatccctt tgatgattgc ttctctgaag 1741 aggcccccaa caccaccaag cacaagctgt catcctttct gttcagttac ttgtcggtcc 1801 agaacaggag gaagacaacg cggtccctca gctgcaacag tgtgcctatg agtgcccaga 1861 agtcactccc cgcagacgct tcactgaaga atgggggctc cttccgggcc agaatctttt 1921 ccgggttccc agaacaaatg atgatgatga agaaaggtgc cttcaaaaag ctgatcaagt 1981 tctacagcgt ccccagcttt cctgaatgca gttctcagtg tgctcgccag ctaccgtgct 2041 gccccctgga ggccatggtg tagagtcctc aatcagaatg caagggtgcc tgtgcttcag 2101 ggagttgggg aaccctcgaa attgcctgca gtttgtgtgc ttattatgtg tgtgtgcatc 2161 ttgagggaag caagcccatt attttgatca taacctcaca gggtcttcgt gatccacaac 2221 agattgtaac tgggaagttt aagcgggcat gctccagagg ttgcaggcgc ttgtgtgata 2281 gaaggggctg agacggtggc atgctgttaa gcttgtaatg tgaaaaacaa cttagaaata 2341 aattgtgctt atatctaaaa aaaaaaaaaa a 1 cttccacctc ctgcgtgtcc atctgtgaga aggagccaga gcccaaggga gacgatggag 61 cctgaggagt acagagagag agggagagag atggtggatt acatctgcca gtacctgagc 121 actgtgcggg agagacgtgt gacgccagac gtgcagcctg gCtacctgcg agcccagctg 181 cctgagagtg ctcctgagga ccccgacagc tgggacagca tctttgggga cattgaacga 241 atcatcatgc ctggggtggt acattggcag agcccccata tgcacgccta ctacccagcc 301 ctcacctctt ggccctccct gctaggagac atgctggctg atgccatcaa ctgcttggga 361 ttcacctggg catccagccc tgcgtgtaca gagctggaga tgaacgtcat ggactggttg 421 gcaaaaatgc tgggacttcc agagcacttc ttgcaccacc accccagcag ccagggcgga 481 ggcgtcctgc agagcacggt cagtgaatcc actttgattg ccctgctggc agcaaggaag 541 aacaaaatcc tggaaatgaa aacgtctgag cccgatgctg atgagtcctg cctaaatgcc 601 cgactcgtgg cctatgcctc tgaccaggct cactcctctg tggaaaaggc tggtttgatt 661 tcccttgtga agatgaaatt tctgcctgtg gatgacaact tCtcactccg aggggaagct 721 cttcagaagg ccatcgagga agacaagcag cggggcttgg tgcccgtctt tgtctgtgca 781 acactaggga ccactggggt ctgtgcattt gactgcctgt cagagctggg ccccatctgt 841 gcccgtgagg ggctgtggct ccacatcgat gctgcttatg caggcactgc cttcctgtgc 901 cccgagttcc gggggtttct gaaggggatt gagtatgccg actccttcac ctttaatcct 961 tccaagtgga tgatggtgca ttttgactgt actgggttct gggtcaagga caagtacaag 1021 ctgcagcaga ccttcagtgt gaatcccatc tacctcaggc atgccaactc aggcgtggcc 1081 accgacttca tgcactggca catccccctg agccgacggt ttcgctctgt taaactctgg 1141 ttcgtgattc ggtccttcgg ggcgaagaat cttcaagcac atgtcagaca tggtactgaa 1201 atggctaaat attttgaatc tctggtcaga aacgaccctt cctttgaaat tcctgccaag 1261 aggcaccttg gcctggtggt tcctttcgtcta aaggtccta attgtctcac agaaaatgtg WO 00/09525 PCT/US99/17712 EPI-109 1231 1321 ttaaaggaaa tagctaaagc tggccgtctc ttcctcatcc cggccaczat ccaggacaag 1381 ttaatcatcc gtttcactgt gacatcccag tttaccacta gggatgacat cctgagagac 1441 tggaatctca ttcgagatgc tgccactctc atcctgagtc agcactgtac ttcccaaccc 1501 agccctcggg ttgggaacct catctcccaa atcaggggtg ccagagcctg ggcctgtgga 1561 acgtccctrc agtctgtcag tggggcagga gatgatccag tccaggccag gaagatcatc 1621 aagcagcctc agcgtgtggg agccggtccc atgaaaaggg aaaatggcct ccatcttgaa 1681 accctgctgg acccagttga tgactgcttt tcagaagagg ccccagatgc caccaagcac 1741 aagctgtcct ccttcctgtt cagttacttg tctgtgcaga ctaagaagaa gacggtgcgc 1801 tccctcagtt gcaacagtgt gccagtgagt gctcagaagc cactgcccac agaggcctct 1861 gtgaagaaug ggggctcctc cagggtcaga atcttttcca ggtztccaga agacatgatg 1921 atgctgaaga aaagtgcctt caaaaaactc atcaaattct acagcgtccc cagctttcct 1981 gaatgcagct ctcaatgtgg actccagctg ccctgttgcc ctctgcaggc catggtttag 2041 acacagggcc ttcagccaga gtctgaggat atacttcagg gactctgtga acccctcaca 2101 attgtatgcc aactttgtgt gcttatgtgt acatgcattt ttcttggggc gagttcataa 2161 ttttaatcaa attctcatag gggttcatga cccacaatag gatacaaacg aagagtttaa 2221 gccagcatga tccagatggg ttcagcagtc tggtcagtga gaaagggccg agggtagaca 2281 ggcagcttct gtggttcagc ttgtgacatg atatataaca cagaaataaa ttatgcttgt 2341 ccctgaaaca aaaaa 1 agtgcgcagg actggcaaga gggaagccgg gctgctccac gcctttcacg ccttccacct 61 cctgcgtgtc catctgtgag aaggagccag agcccaaggg agatgatgga gcctgaggag 121 tacagagaga gagggagaga gatggtggat tacatctgcc agtacctgag cactgtgcgg 181 gagagacgtg tgacgccaga cgtgcagcct ggctacctgc gagcccagct gcctgagagt 241 gctcctgagg accccgacag ctgggacagc atctttgggg acattgaacg aatcatcatg 301 cctggggtgg tacattggca gagcccccat atgcacgcct actacccagc cctcacctct 361 tggccctccc tgctaggaga catgctggct gatgccatca actgcttggg attcacctgg 421 gcatccagcc ctgcgtgtac agagctggag atgaacgtca tggactggtt ggcaaaaatg 481 ctgggacttc cagagcactt cttgcaccac caccccagca gccagggcgg aggcgtcctg 541 cagcagacgg tcagtgaatc cactttgatt gccctgctgg cagcaaggaa gaacaaaatc 601 ctggaaatga aaacgtctga gcccgatgct gatgagtcct gcctaaatgc ccgactcgtg 661 gcctatgcct ctgaccaggc tcactcctct gtggaaaagg ctggtttgat ttcccttgtg 721 aagatgaaat ttctgcctgt ggatgacaac ttctcactcc gaggggaagc tcttcagaag 781 gccatcgagg aagacaagca gcggggcttg gtgcccgtct ttgtctgtgc aacactaggg 841 accactgggg tctgtgcatt tgactgcctg tcagagctgg gccccatctg tgcccgtgag 901 gggctgtggc tccacatcga tgctgcttat gcaggcactg ccttcctgtg ccccgagttc 961 cgggggtttc tgaaggggat tgagtatgcc gactccttca cctttaatcc ttccaagtgg 1021 atgatggtgc attttgactg tactgggttc tgggtcaagg acaagtacaa gctgcagcag 1081 accttcagtg tgaatcccat ctacctcagg catgccaact caggcgtggc caccgacttc 1141 atgcactggc agatccccct gagccgacgg tttcgctctg ttaaactctg gttcgtgatt 1201 cggtccttcg gggtgaagaa tcttcaagca catgtcagac atggtactga aatggctaaa 1261 tattttgaat ctctggtcag aaacgaccct tcctttgaaa ttcctgccaa gaggcacctt 1321 ggcctggtgg tttttcgtct aaagggtcct aattgtctca cagaaaatgt gttaaaggaa 1381 atagctaaag ctggccgtcc cttcctcatc ccggccacta tccaggacaa gttaatcatc 1441 cgtttcactg tgacatccca gtttaccact agggatgaca tcctgagaga ctggaatctc 1501'attcgagatg ctgccactct catcctgagt cagcactgta cttcccaacc cagccctcgg 1561 gttgggaacc tcatctccca aatcaggggt gccagagcct gggcctgtgg aacgtccctt 1621 cagtctgtca gtggggcagg agatgatcca gtccaggcca ggaagatcat caagcagcct 1681 cagcgtgtgg gagccggtcc catgaaaagg gaaaatggcc tccatcttga aaccctgctg 1741 gacccagttg atgactgctt ttcagaagag gccccagatg ccaccaagca caagctgtcc 1801 tccttcctgt tcagttactt gtctgtgcag actaagaaga agacggtgcg ctccctcagt 1861 tgcaacagtg tgccagtgag tgctcagaag ccactgccca cagaggcctc tgtgaagaat 1921 gggggctcct ccagggtcag aatcttttcc aggtttccag aagacatgat gatgctgaag 1981 aaaagtgcct tcaaaaaact catcaaattc tacagcgtcc ccagctttcc tgaatgcagc 2041 tctcaatgtg gactccagct gccctgttgc cctctgcagg ccatggttta gacacagggc 2101 cttcagcaga gtctgaggat atacttcagg gactctgtga acccctcaca attgtatgcc 2161 aactttgtgt gcttatgtgt acatgcattt ttcttggggc gagttcataa ttttaatcaa 2221 attctcatag gggctcatga cccacaatag gatacaaacg aagagtttaa gccagcatga 2281 tccagatggg ttcatcagtc tggtcagtga gaaagggccg agggtagaca ggcagcttct 2341 gtggttcagc ttgtgacatg atatataaca cagaaataaa ttatgcttt ccctga (2) INFORMATION FOR SEQ ID NO:64: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1327 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:64: 1 gatccccaga gactttccag atatctgaag aagtcctgat gtcactgccc cggtccttcc 61 ccaggtagag caacactcct cgtcgcaacc caactggctc cccttacctt ctacacacac 121 acacacacac acacacacac acacacacac acacacaaa ccaagacaac actactaagg WO 00/09525 PCT/US99/17712 EPI-109 1232 181 ct:zctta ;g agggggaagt agggataggt aagaggaaag taagggaccz octatccagc 241 ctccatggaa tcctgacttc ttttccttgt tatttcaact tcttccaccc catcttttaa 301 aczt:aga cr ccagccacag aagcttacaa ctaaaagaaa ctctaaggcc aatttaatcc 361 aaggtttcat tctatgtgct ggagatggtg tacagtaggg tgaggaaacc aaattctcag 421 ttggcactgg tgtacccttg tacaggtgat gtaacatctc tgtgcctcag tttgctcact 481 ataaaataaa gacggtaggg gtcatggtga gcactacctg actagcatat aagaagcttt 541 cagcaagtac agactactct tacccacttc ccccaagcac agttggggtg ggggacagct 601 gaagaggtag aaacatgtgc ctgagaatcc taatgaaatc ggggtaaagg agcctggaac 662. acatcccgtg accccgcctg tcctgtagga agccagtctc tggaaaataa aatggaaggg 722. ctgcttggga actttgagga tatttagccc accccctcat ttttacttag ggaaactaag 781 gcccaaagac ctaaggtgac tgcctaagtt agcaaggaga agtcttgggt attcatccca 841 ggttgggggg acccaattat ttctcaatcc cattgtattc tggaatgggc aatttgtcca 901 cgtcactatg acctaggaac acgcgaatga gaacccacag ctgagggcct ctgcgcacag 961 aacagctgtt ctccccagga aatcaacttt ttttaattga gaagctaaaa aattattcta 1021 agagaggtag cccatcctaa aaatagctgt aatgcagaag ttcatgttca accaatcatt 1081 tttgcttacg atgcaaaaat tgaaaactaa gtttattaga gaggttagag aaggaggagc 1141 tctaagcaga aaaaatcctg tgccgggaaa ccttgattgt ggctttttaa tgaatgaaga 1201 ggcctccctg agcttacaat ataaaagggg gacagagagg tgaaggtcta cacatcaggg 1261 gcttgctctt gcaaaaccaa accacaagac agacttgcaa aagaaggcat gcacagctca 1321 gcactgc (2) INFORMATION FOR SEQ ID NO:65: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1601 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:65: 1aaaccacaag acagacttgc aaaagaaggc atgcacagct cagcactqct ctgttgcctg 61 gtcctcctga ctggggtgag ggccagccca ggccagggca cccagtctga gaacagctgc 121 acccacttcc caggcaacct gcctaacatg cttcgagatc tccgagatgc cttcagcaga 181 gtgaagactt tctttcaaat gaaggatcag ctggacaact tgttgttaaa ggagtccttg 241 ctggaggact ttaagggtta cctgggttgc caagccttgt ctgagatgat ccagttttac 301 ctggaggagg tgatgcccca agctgagaac caagacccag acatcaaggc gcatgtgaac 361 tccctggggg agaacctgaa gaccctcagg ctgaggctac ggcgctgtca tcgatttctt 421 ccctgtgaaa acaagagcaa ggccgtggag caggtgaaga atgcctttaa taagctccaa 481 gagaaaggca tctacaaagc catgagtgag tttgacatct tcatcaacta catagaagcc 541 tacatgacaa tgaagatacg aaactgagac atcagggtgg cgactctata gactctagga 601 cataaattag aggtctccaa aatcggatct ggggctctgg gatagctgac ccagcccctt 661 gagaaacctt attgtacctc tcttatagaa tatttattac ctctgatacc tcaaccccca 722. tttctattta tttactgagc ttctctgtga acgatttaga aagaagccca atattataat 781 ttttttcaat atttattatt ttcacctgtt tttaagctgt ttccataggg tgacacacta 841 tggtatttga gtgttttaag ataaattata agttacataa gggaggaaaa aaaatgttct 901 ttggggagcc aacagaagct tccattccaa gcctgaccac gctttctagc tgttgagctg 961 ttttccctga cctccctcta atttatcttg tctctgggct tggggcttcc taactgctac 1021 aaatactctt aggaagagaa accagggagc ccctttgatg attaattcac cttccagtgt 1081 ctcggaggga ttcccctaac ctcattcccc aaccacttca ttcttgaaag ctgtggccag 1141 cttgttattt ataacaacct aaatttggtt ctaggccggg cgcggtggct cacgcctgta 1201 atcccagcac tttgggaggc tgaggcgggt ggatcacttg aggtcaggag ttcctaacca 1261 gcctggtcaa catggtgaaa ccccgtctct actaaaaata caaaaattag ccgggcatgg 1321 tggcgcgcac ctgtaatccc agctacttgg gaggctgagg caagagaatt gcttgaaccc 1381 aggagatgga agttgcagtg agctgatatc atgcccctgt actccagcct gggtgacaga 1441 gcaagactct gtctcaaaaa aataaaaata aaaataaatt tggttctaat agaactcagt 1501 tttaactaga atttattcaa ttcctctggg aatgttacat tgtttgtctg tcttcatagc 1561 agattttaat tttgaataaa taaatgtatc ttattcacat c (2) INFORMATION FOR SEQ ID NO:66: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 4181 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:66: 1 agatcttgta aactgtagaa tgcaccctcc aaaatctatt tgcataagca cacacacaca 61 cacacacaca cacaccccag cagttcttgc ctgcccagat tcctctgcag ctaaagtgat 121 gaaacttact gggcggagct tcctaaaaag attattaggg tctcctgggt tggtgtgcct 181 ttaaaccttt ggactttacc acctcctatc tctcctatct ccttgcaaca aaggttagga 241 gaacaagaat gcagaaaaaa cgggtcctgg atgacatctg agtgcctgct ttgggcttct 301 tgatgagtga gacagaaaat aaaatacaac cccctctttt aaaagccatg cttactcagg 361 ttttccttca tttgcagcta aatacagaaa tgagagaata ttttggagca gggatggaag 421 aagagaggta ttccccttcc cacaaccttc tgatttccca gtacatcccc cactggaaaa 481 attcatttaa aatcagtata ataagcattg attagatgcc tactatgcat ctgggcttga 541 gggcaaactg gactcaggcc ttttggcctc aagaagctca cagtgtgaga gtggcatttg 601 tgtcctcttg aaattcacag gactaaattg tgcccaggct gacattctat ccatccatag 661 gtgcctgcct tctcacttcc ctctcttcat gggctcttgc cttgtaccaa aatccaaacc WO 00/09525 PCT/US99/17712 EPI-109 1233 721 caaatctcct cacatgtaag tgttggcaz catctcag acatgaccta tgggcttggg '81 acttttcccc gtggacccca qtgacrtttc agatgaacag gtatcttcaa aaacttgaga 841 aataggagtc ctgtttgztg ttcttgttgc tttcaata taaggcacag ggtctttatt 901 caaatgttca tactatctct tgacagaaat actatgagac atattgatgg agaagccgtt 961 atctccatat gctaaatgag gacttgcacc agggaacttg cccatggttc tctccaacca 1021 cttaaattct gaaattttga atgagagtgg acagtaattt caaatcaatg gggaaagaat 1081 caaatcttca gcaaatact tgagataatt agctacacat ttcagaacaa ataaagaagt 1141 cagatccggg ccgggcacaa tggctcatgc ctgtaatctc agcactctgg gagqccaagg 1201 cgggcggatc ataaggtcag gagatcgaga ccatcctgg taacacagtg aacccctctc 1261 taataaaaat acaaaaaaaa ataaaaaaac ttagccgggc gtggtgccag gcgcctgtag 1321 tcccagctac tcgggacgct gaggcaggag aatggcttga actcgggagg cagagcttgc 1381 aggtgagctg agatcargcc actgcactcc agcctgggca acagagcgag actctgtctc 1441 aaaaaaaaaa aagaagtcag atcctaacct caaccctatt taacagatta tagatgaaag 1501 aaaggtacaa atggctttta catacctccc ttctccctga cattttgtat gtgtgtgtgt 1561 gtgtatttac acacacatct catataagga aattgaaggg aggctgcctg catccctgag 1621 tcactctccc tctccttctg aatgcttacc tgtgcccaga ccacctcctt agcctcgcac 1681 cctccaggct tacagggcac tcttctatgc ccatcccaag tatagctgaa ccttccaagg 1741 gccagacttg gtgctaagta ccaagtacgc aaagattaat aaaacaatgt cctgtttcag 1801 ggagctcaaa gctgattcgg cagggcatgg tgtgtacatg aatgataacc acgtagggtt 1861 gcaggtttcc tagtgaggta agcacaaggc aagatgggaa acaaaggaag gaggggttca 1921 cagcctcacc cagagtccag aacccctggc ctgcctggtg cccatgctga gtccacttct 1981 ggaacaccca gctcagagag ggggttagac ctgcaggcta acacagacac agcccagaaa 2041 acccaggagc cgagggggaa ggagaaaggt gcaagaaggg gaaacccagg tcctggtccc 2101 cttctctctg cttcctggca gcagaactca gacagaaccc ttaagccagt ctaagtctgg 2161 caggaccagt aagttctgag ttagctccat actagtttct agcaggctct ttctcacttc 2221 ctgattctta ggtttctaca ttgacactcc ctgaagagtt gggaagagac accacagtcc 2281 cctgaccctg atccataggt cacacagcag gcatccacag ggtgggcgtg ggccctctca 2341 tccctccctc ccactcactt cacgctggct gggccccaag gtgtttgcac cccttgcagt 2401 gagtgacctt ctctagtgca gcaagctcag aacctgctgc cactggagtt gtcccattgc 2461 tgatgcagaa aggtgaagaa ctagcagaac actggaaatg ccctccatct gggtccatgg 2521 ctacttaatg ctccctggca ggcaggagga caggtgctat tccctgttgg gacagatgaa 2581 aaacagacac agggaggatg agtgatttgc cctgactata gagtggcagg gccaaggcag 2641 agcccaggcc tcctgcacct aggtcagtgt tcctcccagt tacagtctaa actggaatgc 2701 aggcaaagcc cctgtggaag gggaaggtga aggctcaatc aaaggatccc cagagacttt 2761 ccagatatct gaagaagtcc tgatgtcact gccccggtcc ttccccaggt agagcaacac 2821 tcctcgccgc aacccaactg gctcccctta ccttctacac acacacacac acacacacac 2881 acacacacac acacacacaa atccaagaca acactactaa ggcttctttg ggaaggggaa 2941 gtagggatag gtaagaggaa agtaagggac ctcctatcca gcctccatgg aatcctgact 3001 tcttttcctt gttatttcaa cttcttccac cccatctttt aaactttaga ctccagccac 3061 agaagcttac aactaaaaga aactctaagg ccaatttaat ccaaggtttc attctatgtg 3121 ctggagatgg tgtacagtag ggtgaggaaa ccaaattctc agttggcact ggtgtaccct 3181 tgtacaggtg atgtaacatc tctgtgcctc agtttgctca ctataaaata gagacggtag 3241 gggtcatggt gagcactacc tgactagcat ataagaagct ttcagcaagt gcagactact 3301 cttacccact tcccccaagc acagttgggg tgggggacag ctgaagaggt ggaaacatgt 3361 gcctgagaat cctaatgaaa tcggggtaaa ggagcctgga acacatcctg tgaccccgcc 3421 tgtcctgtag gaagccagtc tctggaaagt aaaatggaag ggctgcttgg gaactttgag 3481 gatatttagc ccaccccctc atttttactt ggggaaacta aggcccaqag acctaaggtg 3541 actgcctaag ttagcaagga gaagtcttgg gtattcatcc caggttgggg ggacccaatt 3601 atttctcaat cccattgtat tctggaatgg gcaatttgtc cacgtcactg tgacctagga 3661 acacgcgaat gagaacccac agctgagggc ctctgcgcac agaacagctg ttctccccag 3721 gaaatcaact ttttttaatt gagaagctaa aaaattattc taagagaggt agcccatcct 3781 aaaaatagct gtaatgcaga agttcatgtt caaccaatca tttttgctta cgatgcaaaa 3841 attgaaaact aagtttatta gagaggttag agaaggagga gctctaagga gaaaaaatcc 3901 tgtgccggga aaccttgatt gtggcttttt aatgaatgaa gaggcctccc tgagcttaca 3961 atataaaagg gggacagaga ggtgaaggtc tacacatcag gggcttgctc ttgcaaaacc 4021 aaaccacaag acagacttgc aaaagaaggc atgcacagct cagcactgct ctgttgcctg 4081 gtcctcctga ctggggtgag ggccagccca ggccagggca cccagtctga gaacagctgc 4141 acccacttcc caggcaacct gcctaacatg cttcgagatC t (2) INFORMATION FOR SEQ ID NO:67: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1314 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 67: 1 gggggggggg atttagagac ttgctcttgc actaccaaag ccacaaagca gccttgcaga 61 aaagagagct ccatcatgcc tggctcagca ctgctatgct gcctgctctt actgactggc 121 atgaggatca gcaggggcca gtacagccgg gaagacaata actgcaccca cttcccagtc 181 ggccagagcc acatgctcct agagctgcgg actgccttca gccaggtgaa gactttcttt 241 caaacaaagg accagctgga caacatactg ctaaccgact ccttaatgca ggactttaag 301 ggttacttgg gttgccaagc cttatcggaa atgatccagt tttacctggt agaagtgatg 361 ccccaggcag agaagcatgg cccagaaatc aaggagcatt tgaattccct gggtgagaag 421 ctgaagaccc tcaggacgcg gctgaggcgc gtcatcgat ttctcccctg tgaaaataag 481 agcaaggcag tggagcaggt gaagagtgat tttaataagc tccaagacca aggtgtctac WO 00/09525 PCT/US99/17712 EPI-109 1234 541 aaggccataa atgaattzga ca-ettcatc aactgcatag aagcatacat gatgatcaaa 601 atgaaaaact aaaacacct; cagtgtgtat tgagtctget ggactccagg acctagacaa 661 agctctctaa atctgatcca gggatcttag ctaacggaaa caactccttg gaaaacctc; 721 tttgtacctc tctccgaaat arttattacc tctgatacct cagttcccat tctatttatt 781 cactgagctt ctctgtgaac ratttagaaa gaagcccaat attataattt tacagtatt: 841 attattttta acctgtgttt aagctgtttc cattggggac acrttatagt atttaaaggg 901 agattatatt atatgatggg aggggttctt ccttgggaag caattgaagc ttctattcta 961 aggctggcca cacttgagag ctgcagggcc ctttgctatg gtgtcctttc aattgctctc 1021 atccctgagt tcagagctcc zaagagagtt gtgaagaaac tcatgggtct tgggaagaga 1081 aaccagggag atcctttaat gatcattcct gcagcagctc agagggttcc cctactgtca 1141 tcccccagcc gcttcatccc tgaaaactgt ggccagtttg ttatttataa ccacctaaaa 1201 ttagttctaa tagaactcat ttttaactag aagtaatgca attcctctgg gaatggtgta 1261 ttgtttgtct gcctttgtag cagcatctaa ttttgaazaa atggatctta ttcg (2) INFORMATION FOR SEQ ID NO:68: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 7207 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:68: 1 cagtcaggag agagggcagt gagggtccat gctagctggg tcttgagcct cttctggggt 61 tcagtctctg atctacagca atgtgtccac acctaaaaca tcagctcaga gaggcagttg 121 cttctgctgt tggaaacgga catcccaaaa aaaaacaaaa aacagaaatc aaaagggaag 181 gagaaagtga aagggatgga ggcagcttgt ccccttccct gtgcttgctg ctggtagaaa 241 actcagcctg gaactgaccg gagcagcagt tcttgagtca attccattcc aacttctaga 301 agattctttt cccgtcgaag agtgtcagga ggagaggcca gacccccttg atcctgatct 361 gccagccact gcatcaaata agacgagata accccgagtt cctgttctac cagccctggt 421 gtggtaaccc tctccaatgg ggcaggcttg gaaccctgtg ccaacgaaga tcctcccccg 481 tactgatgca ggaaggacag cccgggagtg taccctctac atgggtctac ttttatttaa 541 gcaaacattc cctggtcaac aggacgtgta gcattgcccc cccccttggg tcacacagaa 601 aacaggtacc aggaggacaa gtagttgctt gcccagggta cagaatgaaa ggcaataggg 661 gactctaggc gaatgttctt cccacccaaa ctgaggtagt aggagaagtc cctactgaag 721 ggaaggtcca gacataatca aaggactacc agagatctcc caggtatctg tagaagtact 781 aacatctcca tccttcaaca gctacaggtt acacgtctcc aaggctggga cattgtaaaa 841 cagggccatg gtaaggtcta cccgacagca cagagcaagc ctcccagaag tctgagttcc 901 ttctcctaac ttctcatgct gggatctgag cttcttcgtg aaacacgggg cagaggaggc 961 accagaactc tcctctgacc aactgcccca cagcacacat atcctcaaag gatagtcttg 1021 aatacgtgat ggaagaatta aagagagtga ggtctgaaga aaatcagccc tctcggggtt 1081 tcctttgggt aactgagtgc taaggtgact tccgagtcag caagaaatat cggacgttca 1141 acccaggttg agtggaggaa acaattattt ctcaatccta atatgttctg gaatagccca 1201 tttatccacg tcattatgac ctgggagtgc gtgaatggaa tccacagatg agggcctctg 1261 tacatagaac agctgtctgc ctcaggaaat acaactttta gtattgagaa gctaaaaaga 1321 aaaaaaaatt aaaagagagg tagcccatac taaaaatagc tgtaatgcag aagttcattc 1381 cgaccagttc tttagcgctt acaatgcaaa aaaaagggaa aggaaaaaaa aaaagaaaga 1441 aattaaactc aaaaattgca tggtttagaa gagggaggag gagcctgaat aacaaaaacc 1501 tttgccagga aggccccact gagccttcag tataaaaggg ggaccaagaa caggaggtct 1561 acatttagag acttgctctt gcactaccaa agccacaagg cagccttgca gaaaagagag 1621 ctccatcatg cctggctcag cactgctatg ctgcctgctc ttactgactg gcatgaggat 1681 cagcaggggc cagtacagcc gggaagacaa taactgcacc cacttcccag tcggccagag 1741 ccacatgctc ctagagctgc ggactgcctt cagccaggtg aagactttct ttgtaagtat 1801 gagctcgcct agcctttctt cctgccatca cctgaaatat gcattctgat ggaactgcaa 1861 aaatagctct ccttctcctc ctccttctcc tccttctctt tctcctcctc tgctttctcc 1921 tccttctctt cctcctcctt ctcttcttcc tcctctccct cttcctcctc cagctcttac 1981 ctcatgctgc tcctccccta tttccagcac ctattaccct taaacttaaa tctagagagt 2041 cctagggaaa gccatgagtt aaactaaacc caggcacatc cgaaaagcta actaggaggt 2101 gaatgcattg tctctcccat gctcaagaac tttctgttaa gtttccaata aggctccatg 2161 ttttgctggc taggacaaaa gtctgtggtc tctgcgtagt ctctagatct gggggacaga 2221 ggtttggggg tttgaagcag caccagcata gagagcttgc attacaaaag tattcccctt 2281 tcagagctcc tggaactggt atggaggtcc aaagaaggca gagagctatg caaaacaggc 2341 tttctataag ggactccaga aaggaagggt tgacacaggt gctcttgaaa cctgatctga 2401 ctcatctgaa agaagaccgg gcctgggtct aacttctccc agtcagttaa attcagtcag 2461 aagtttttaa aaacaactgg atcccaagag gaaggacttt gatttaactc cgggctctag 2521 cactgtcaaa tcctgttctt aaaactctcc tttccacagt tgccagggca tttgaattga 2581 ttacaaattc aaaactctac aaatggaaaa gtattcaaat gacatgcaca ttgggtattt 2641 tccccagtcc ttgcattcac gttctttatg ttcttccagc aaacaaagga ccagctggac 2701 aacatactgc taaccgactc cttaatgcag gactttaagg taagagtccg gtgggtgctg 2761 gggagcgacc aagcgattag ggacgggacg ggaggtgctg cttgtgacag cagagctggg 2821 tctgatgcct tgactttcaa aaagagaagt gagaagacct tgactcagca tatcgccagc 2881 agtcaagggt tgtgaagagc tcattctgtg gtaaagggag aaaatgtaac tagaaggggc 2941 ggggatgggg ggggggtccc taggaacagg acagtccatc aaggttagca gcaacagatc 3001 accattccag taagtcacac ccaacctctg atccctgcct ctagggttac ttgggttgcc 3061 aagccttatc ggaaatgatc cagttttacc tggtagaagt gatgccccag gcagagaagc 3121 atggcccaga aatcaaggag catttgaatt ccctgggtga gaagctgaag accctcagga 3181 tgcggctgag gcgctgtgtg agtagcagat gcgttcttcc ccacccccaa tccccttaga WO 00/09525 PCT/US99/17712 EPI-109 1235 3241 gccacccaac aaatactgtc tcctacagcc cagtcaggcc acargcatcc agagacacac 3301 acagactaaa caggagacta ggtaaatcta gagagacgcc tgtttggtgt cgggtctct 3361 gctcatctgt ctctgagcga gtgtgggagt gactttgagg caczcacacg tgaagatttg 3421 cqcatagccr tcctgttatt tgtgagtcat tgtgggttat tagctaczcc cctctctctc 3481 catgggaagg ctggggcttc agtcatggct ccctcacctc tgggctacca gctgaggctc 3541 ccaagcacag gaaaacattc atctctttat ctcatctttt gggaagcaaa ttcaqtggca 3601 cagagctggg ctgacaggac gctggtgttt cagaagggcc agaagactgc tatccctaag 3661 ccagtatcta tgaataatac agtcggggca tctatgtctc tgaagcgatg ccttggctgc 3721 tcttgttttt cttacttctc tcactgatac tgggacatta gctggagtcc acttgtgcaa 3781 cggtctggc ctgacgattt ggccccagta gctgagactt tcgctcctct ctcagacacc 3841 tagaaatagt tcatggtggt tgagattgga gatagacaag aagagacact aaaaacagaa 3901 caggtgcctt ggagctctga gagacaaaac ccgagacctg agttcacacc cacacttaqc 3961 aagccatctt agtgattgca aagacataca ttgcatcttt ctaggctgtc ctctgctgtc 4021 cccctcagtc cctaccgaaa tagataagga ccaatcacgg ctcagttctc cctgggagct 4081 aagaagtggg cattgaagat gagcaagggt gtctccttcc tcacacaaca agatagtttc 4141 ccccaagtac catggatgca gaattcaagc aagaattacc aatgctctct tttttcttct 4201 tcagcatcga tttctcccct gtgaaaataa gagcaaggca gtggagcagg tgaagagtga 4261 ttttaataag gtaagtggca aagggggcga gtgtaacaag acctctgtct actcaccaaa 4321 gcgcagaagg agggcgggag ctattctgca cctggagtgt gggaacccag caaatggtgt 4381 gacctcctct gccagttaga aagccaccac ctcagttaca tttgttttct gcaaagcgtc 4441 tctggcagtt tctaaatgac tgctccactt ttgcaggctt ttggcttaga ctgaccagac 4501 agcctatgag cacagggcac taggtgttga ggagagtgac ataggaaaca gaaagtacag 4561 aaagtacctt gttgggaaac aggctgaacc cacaagtaca gaaagcagac atgaattaat 4621 ttactcaggt acatcattgg ggctcagcct ggatgcccct cccccaaatc agaacgagca 4681 gaaagcagaa ttcttacttg tcccggggca ctttccacct ggcaaacaaa atgaggtttc 4741 acacttccaa ctgcctgtga acctattcaa ccctagttcc cagaagccat gtggcctaca 4801 tcatcact tgtgggctag gcagagacac ctggcagggc tctaacatta gtgggcatga 4861 attccatgac agcaggtcag agctgcaggg tgaggactgc ctacacactc aaaacataaa 4921 aaaaaaaaaa aaaaaacacc aaccatttcc ctgctatctc tatcactgcc ctgcttacaa 4981 actgctccct ctggcatctt tgcataacat tctgcataag cattatatga gcactggcct 5041 cttaaaaaaa attagttgaa aaggtgccac cctgaagaca gtgctttggg gactgaatgc 5101 ttcccttgct gactcctggc agtgcttaaa gctgggagaa ggttggtccc accacatcct 5161 gactactaca gtatagttgt ctctcttctt tcatttccct gtCcCattt ctttattgta 5221 cataaagtaa ctggtgtatg tgcacacaca tagtgctctc tctttctttt ccttttttaa 5281 actaaatggc cgatgttctg ttctggttgg catcagatgg agatggtctg ggggaaagta 5341 ctgggtttgt gaaaataccc ccttctccat tagtggcatg ctctttcagc tcttatcttt 5401 atattccagt aagttatttt gctctcattg ttttaacaaa agaacccaac aacaccaaat 5461 ctttgcatac cttgttcgat tggagaattt taatgttttt catttatcat tgtaaaaccg 5521 aggacaattt tataactttt ttgtacgtgg ctgttacatg tagggcaatc tgtctttaag 5581 tagggataaa ttactcttga ataaaatgat cctagatagt tttcccttca agtcaagcgt 5641 cttgttgttt aaataaactt cttgtttaaa atgaaaaaaa aaaaaacaaa caaacaaaaa 5701 aaagctggga gaaqgtatag gagaaacagg ggaaggcacg gccccttccc aaagcagacg 5761 gacaaatctt tgggtccttc agctcccaac acaagaaagc agagatcttt ctatgctcag 5821 catccttccc agggcaggga gcccctcagc ccaccaatgg gtactaacca gatgcttctc 5881 tccccacaca gctccaagac caaggtgtct acaaggccat gaatgaattt gacatcttca 5941 tcaactgcac agaaqcatac atgatgatca aaatgaaaag ctaaaacacc tgcagtgtgt 6001 attgagtctg ctggactcca ggacctagac agagctctct aaatctgatc cagggatctt 6061 agctaacgga aacaactcct tggaaaacct cgtttgtacc tctctccgaa atatttatta 6121 cctctgatac ctcagttccc attctattta ttcactgagc ttctCtgtga actatttaga 6181 aagaagccca atattataat tttacagtat ttattatttt taacctgtgt ttaagctgtt 6241 tccattgggg acactttata gtatttaaag ggagattata ttatatgatg ggaggggttc 6301 ttccttggga agcaattgaa gcttctattc taaggctggc cacacttgag agctgcaggg 6361 ccctttgcta tggtgtcctt tcaattgctc tcatccctga gttcagagct cctaagagag 6421 ttgtgaagaa actcatgggt cttgggaaga gaaaccaggg agatcctttg atgatcattc 6481 ctgcagcagc tcagagggtt cccctactgt catcccccag ccgcttcatc cctgaaaact 6541 gtggccagtt tgttatttat aaccacctaa aattagttct aatagaactc atttttaact 6601 agaagtaatg caattcctct gggaatggtg tattgtttgt ctgcctttgt agcagactct 6661 aattttgaat aaatggatct tattcgaatt acagtgtggt gtctattgag ttctgtctga 6721 tttaaaagaa aaatccctta aaattccaga gggcagaagc agtgaatctt agactccaca 6781 aaaagaatgc cagcaacctc tccaggaagg ggttgagctc ggatcagatc agaggaaagt 6841 cttgcctggc tttcaaagca tcagcataaa ctactgatat cttcaagctc agtcctttaa 6901 aatgtgtcct gaaaccttaa aaggcattct accttccaaa gctagggaag gtgattctaa 6961 gtaaccatcg gaaggaagtg ggaagcatca aagctgaaac tctgagacaa aatgttgggg 7021 ttaaaaatgg aagctagggg caggagggtg gggagatggc tcagcagtta gagtgtgtgc 7081 cggcaccagt gagacaggag ttcatatcct tggaatccaa ccaacacaca accaacacta 7141 ggcaagagat acctaatgtg tcagtggttg cttcaagctc cagaggcct ggggtgaact 7201 tagatcc (2) INFORMATION FOR SEQ ID NO:69: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15530 base pairs (B) TYPE: aucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQLJENCE DESCRIPTION: SEQ ID NO:69: WO 00/09525 PCT/US99/17712 EPI-109 1236 gatccccaga aactztccag atatctgaag aagtcctgat gtcactgccc cggtccttcc 61 ccaggzagag caacactcct cgtcgcaacc caactggctc cccttacctt ctacacacac 121 acacacacac acacacacac acacacacac acacacaaat ccaagacaac actactaagg 181 cttctttggg agggggaagt agggataggt aagaggaaag taagggacct cctatccagc 241 ctccatggaa tcctgacttc ttttccttgt tatttcaact tcttccaccc catcttttaa 301 actttagact ccagccacag aagcttacaa ctaaaagaaa ctctaaggcc aatttaatcc 361 aaggtttcat tctatgtgct ggagatggtg tacagtaggg tgaggaaacc aaattctcag 421 ttggcactgg tgtacccttg tacaggtgat gtaacatctc tgtgcctcag tttgctcact 481 ataaaataga gacggtaggg gtcatggtga gcactacctg actagcatat aagaagcttt 541 cagcaagtgc agactactct tacccacttc ccccaagcac agttggggtg ggggacagct 601 gaagaggtgg aaacatgtgc ctgagaatcc taatgaaatc ggggtaaagg agcctggaac 661 acatcctgtg accccgcctg tcctgtagga agccagtctc tggaaagtaa aatggaaggg 721 ctgcttggga actttgagga tatttagccc accccctcat ttttacttgg ggaaactaag 781 gcccagagac ctaaggtgac tgcctaagtt agcaaggaga agtcttgggt attcatccca 841 ggttgggggg acccaattat ttctcaatcc cattgtattc tggaatgggc aatttgtcca 901 cgtcactgtg acctaggaac acgcgaatga gaacccacag ctgagggcct ctgcgcacag 961 aacagctgtt ctccccagga aatcaacttt ttttaattga gaagctaaaa aattattcta 1021 agagaggtag cccatcctaa aaatagctgt aatgcagaag ttcatgttca accaatcatt 1081 tttgcttacg atgcaaaaat tgaaaactaa gtttattaga gaggttagaq aaggaggagc 1141 tctaagcaga aaaaatcctg tgccgggaaa ccttgattgt ggctttttaa tgaatgaaga 1201 ggcctccctg agcttacaat ataaaagggg gacagagagg tgaaggtcta cacatcaggg 1261 gcttgctctt gcaaaaccaa accacaagac agacttgcaa aagaaggcat gcacagctca 1321 gcactgc 1aaaccacaag acagacttgc aaaagaaggc atgcacagct cagcactgct ctgttgcctg 61 gtcctcctga ctggggtgag ggccagccca ggccagggca cccagtctga gaacagctgc 121 acccacttcc caggcaacct gcctaacatg cttcgagatc tccgagatgc cttcagcaga 181 gtgaagactt tctttcaaat gaaggatcag ctggacaact tgttgttaaa ggagtccttg 241 ctggaggact ttaagggtta cctgggttgc caagccttgt ctgagatgat ccagttttac 301 ctggaggagg tgatgcccca agctgagaac caagacccag acatcaaggc gcatgtgaac 361 tccctggggg agaacctgaa gaccctcagg ctgaggctac ggcgctgtca tcgatttctt 421 ccctgtgaaa acaagagcaa ggccgtggag caggtgaaga atgcctttaa taagctccaa 481 gagaaaggca tctacaaagc catgagtgag tttgacatct tcatcaacta catagaagcc 541 tacatgacaa tgaagatacg aaactgagac atcagggtgg cgactctata gactctagga 601 cataaattag aggtctccaa aatcggatct ggggctctgg gatagctgac ccagcccctt 661 gagaaacctt attgtacctc tcttatagaa tatttattac ctctgatacc tcaaccccca 721 tttctattta tttactgagc ttctctgtga acgatttaga aagaagccca atattataat 781 ttttttcaat atttattatt ttcacctgtt tttaagctgt ttccataggg tgacacacta 841 tggtatttga gtgttttaag ataaattata agttacataa gggaggaaaa aaaatgttct 901 ttggggagcc aacagaagct tccattccaa gcctgaccac gctttctagc tgttgagctg 961 ttttccctga cctccctcta atttatcttg tctctgggct tggggcttcc taactgctac 1021 aaatactctt aggaagagaa accagggagc ccctttgatg attaattcac cttccagtgt 1081 ctcggaggga ttcccctaac ctcattcccc aaccacttca ttcttgaaag ctgtggccag 1141 cttgttattt ataacaacct aaatttggtt ctaggccggg cgcggtggct cacgcctgta 1201 atcccagcac tttgggaggc tgaggcgggt ggatcacttg aggtcaggag ttcctaacca 1261 gcctggtcaa catggtgaaa ccccgtctct actaaaaata caaaaattag ccgggcatgg 1321 tggcgcgcac ctgtaatccc agctacttgg gaggctgagg caagagaatt gcttgaaccc 1381 aggagatgga agttgcagtg agctgatatc atgcccctgt actccagcct gggtqacaga 1441 gcaagactct gtctcaaaaa aataaaaata aaaataaatt tggttctaat agaactcagt 1501 tttaactaga atttattcaa ttcctctggg aatgttacat tgtttgtctg tcttcatagc 1561 agattttaat tttgaataaa taaatgtatc ttattcacat C 1 agatcttgta aactgtagaa tgcaccctcc aaaatctatt tgcataagca cacacacaca 61 cacacacaca cacaccccag cagttcttgc ctgcccagat tcctctgcag ctaaagtgat 121 gaaacttact gggcggagct tcctaaaaag attattaggg tctcctgggt tggtgtgcct 181 ttaaaccttt ggactttacc acctcctatc tctcctatct ccttgcaaca aaggttagga 241 gaacaagaat gcagaaaaaa cgggtcctgg atgacatctg agtgcctgct ttgggcttct 301 tgatgagtga gacagaaaat aaaatacaac cccctctttt aaaagccatg cttactcagg 361 ttttccttca tttgcagcta aatacagaaa tgagagaata ttttggagca gggatggaag 421 aagagaggta ttccccttcc cacaaccttc tgatttccca gtacatcccc cactggaaaa 481 attcatttaa aatcagtata ataagcattg attagatgcc tactatgcat ctgggcttga 541 gggcaaactg gactcaggcc ttttggcctc aagaagctca cagtgtgaga gtggcatttg 601 tgtcctcttg aaattcacag gactaaattg tgcccaggct gacattctat ccatccatag 661 gtgcctgcct tctcacttcc ctctcttcat gggctcttgc cttgtaccaa aatccaaacc 721 caaatctcct cacatgtgag tgttggcatt catgtctcag acatgaccta tgggcttggg 781 acttttcccc gtggacccca gtgacttttc agatgaacag gtatcttcaa aaacttgaga 841 aataggagtc ctgtttgttg ttcttgttgc tttgtcaata taaggcacag ggtctttatt 901 caaatgttca tactatctct tgacagaaat actatgagac atattgatgg agaagccgtt 961 atctccatat gctaaatgag gacttgcacc agggaacttg cccatggttc tctccaacca 1021 cttaaattct gaaattttga atgagagtgg acagtaattt caaatcaatg gggaaagaat 1081 caaatcttca gcaaatggct tgagataatt agctacacat ttcagaacaa ataaagaagt 1141 cagatccggg ccgggcacag tggctcatgc ctgtaatctc agcactctgg gaggccaagg 1201 cgggcggatc ataaggtcag gagatcgaga ccatcctggt taacacagtg aacccctctc 1261 taataaaaat acaaaaaaaa ataaaaaaac ttagccgggc gtggtgccag gcgcctgtag 1321 tcccagctac tcgggacgct gaggcaggag aatggcttga actcgggagg cagagcttgc 1381 aggtgagctg agatcatgcc actgcactcc agcctgggca acagagcgag actctgtctc 1441 aaaaaaaaaa aagaagtcag atcctaacct caaccctatt taacagatta tagatgaaag WO 00/09525 PCT/US99/17712 EPI-109 1237 7 E 0 aaaggtacaa atagct::,a catacctccc 'tcrccctga cattttgtat atgtgtgtgt -761 gtgtatttac acacacazct catataagga aattgaaggg aggctgcctg catccctgag 1621 tcactczccc tctcct::g aatgcttacc tgtgcccaga ccacctcctt agcctcgcac 1681 cctccaggct tacagggcac tcttctatgc cCatcccaag tatagctgaa ccttccaagg 741 gccagacttg gtgctaaata ccaagtacgc aaagattaat aaaacaatgt cctgtttcag 1801 ggagctcaaa gctgattcag cagggcatgg tgtgtacatg aatgataacc acgtagggtt 1861 gcaggtttcc tagtgaaa agcacaaggc aagatgggaa acaaaggaag gaggggttca 1921 cagcctcacc cagagtccaa aacccctggc ctgcctgtg cccatgctga gtccacttct 1981 ggaacaccca gctcaqaaag ggggttaaac ctgcaggcta acacagacac agcccagaaa 2041 acccaggagc cgagggggaa ggagaaaggt gcaagaaggg gaaacccagg tcctggtccc 2101 cttctctctg cttcctauca gcagaactca gacagaaccc ttaagccagt ctaagtctgg 2161 caggaccagt aaattctaag ttagctccat actagtttct agcaggctct ttctcacttc 2221 ctgattctta ggtttctaca ttgacactcc ctgaagagtt gggaagagac accacagtec 2281 cctgaccctg atccataat cacacagcag gcatccacag ggtgggcgtg ggccctctca 2341 tccctccctc ccactcactt cacgctggct gggccccaag gtgtttgcac cccttgcagt 2401 gagtgacctt ctctagtgca gcaagctcag aacctgctgc cactggagtt gtcccattgc 2461 tgatgcagaa aggtgaaaaa ctagcagaac actggaaatg ccctccatct gggtccatgg 2521 ctacttaatg ctccctggca ggcaggagga caggtgctat tccctgttgg gacagatgaa 2581 aaacagacac agggaggatg agtgatttgc cctgactata gagtggcagg gccaaggcag 2641 agcccaggcc tcctgcacct aggtcagtgt tcctcccagt tacagtctaa actggaatgc 2701 aggcaaagcc cctgtggaag gggaaggtga aggctcaatc aaaggatccc cagagacttt 2761 ccagatatct gaagaaatcc tgatgtcact gccccggtcc ttccccaggt agagcaacac 2821 tcctcgccgc aacccaactg gctcccctta ccttctacac acacacacac acacacacac 2881 acacacacac acacacacaa atccaagaca acactactaa ggcttctttg ggaaggggaa 2941 gtagggatag gtaagaggaa agtaagggac ctcctatcca gcctccatgg aatcctgact 3001 tcttttcctt gttatttcaa cttcttccac cccatctttt aaactttaga ctccagccac 3061 agaagcttac aactaaaaaa aactctaagg ccaatttaat ccaaggtttc attctatgtg 3121 ctggagatgg tgtacaqtag ggtgaggaaa ccaaattctc agttggcact ggtgtaccct 3181 tgtacaggtg atgtaacatc tctgtgcctc agtttgctca ctataaaata gagacggtag 3241 gggtcatggt gagcactacc tgactagcat ataagaagct ttcagcaagt gcagactact 3301 cttacccact tcccccaagc acagttgggg tgggggacag ctgaagaggt ggaaacatgt 3361 gcctgagaat cctaatgaaa tcggggtaaa ggagcctgga acacatcctg tgaccccgcc 3421 tgtcctgtag gaagccagtc tctggaaagt aaaatggaag ggctgcttgg gaactttgag 3481 gatatttagc ccaccccctc atttttactt ggggaaacta aggcccagag acctaaggtg 3541 actgcctaag ttagcaagga gaagtcttgg gtattcatcc caggttgggg ggacccaatt 3601 atttctcaat cccattgtat tctggaatgg gcaatttgtc cacgtcactg tgacctagga 3661 acacgcgaat gagaacccac agctgagggc ctctgcgcac agaacagctg ttctccccag 3721 gaaatcaact ttttttaatt gagaagctaa aaaattattc taagagaggt agcccatcct 3781 aaaaatagct gtaatgcaga agttcatgtt caaccaatca tttttgctta cgatgcaaaa 3841 attgaaaact aagtttatta gagaggttag agaaggagga gctctaagga gaaaaaatcc 3901 tgtgccggga aaccttgatt gtggcttttt aatgaatgaa gaggcctccc tgagcttaca 3961 atataaaagg gggacagaga ggtgaaggtc tacacatcag gggcttgctc ttgcaaaacc 4021 aaaccacaag acagacttgc aaaagaaggc atgcacagct cagcactgct ctgttgcctg 4081 gtcctcctga ctggggtgag ggccagccca ggccagggca cccagtctga gaacagctgc 4141 acccacttcc caggcaacct gcctaacatg cttcgagatc t 1gggggggggg atttagagac ttgctcttgc actaccaaag ccacaaagca gccttgcaga 61 aaagagagct ccatcatgcc tggctcagca ctgctatgct gcctgctctt actgactggc 121 atgaggatca gcaggggcca gtacagccgg gaagacaata actgcaccca cttcccagtc 181 ggccagagcc acatgctcct agagctgcgg actgccttca gccaggtgaa gactttcttt 241 caaacaaagg accagctgga caacatactg ctaaccgact ccttaatgca ggactttaag 301 ggttacttgg gttgccaagc cttatcggaa atgatccagt tttacctggt agaagtgatg 361 ccccaggcag agaagcatgg cccagaaatc aaggagcatt tgaattccct gggtgagaag 421 ctgaagaccc tcaggatgcg gctgaggcgc tgtcatcgat ttctcccctg tgaaaataag 481 agcaaggcag tggagcaggt gaagagtgat tttaataagc tccaagacca aggtgtctac 541 aaggccatga atgaatttga catcttcatc aactgcatag aagcatacat gatgatcaaa 601 atgaaaagct aaaacacctg cagtgtgtat tgagtctgct ggactccagg acctagacag 661 agctctctaa atctgatcca gggatcttag ctaacggaaa caactccttg gaaaacctcg 721 tttgtacctc tctccgaaat atttattacc tctgatacct cagttcccat tctatttatt 781 cactgagctt ctctgtgaac tatttagaaa gaagcccaat attataattt tacagtattt 841 attattttta acctgtgttt aagctgtttc cattggggac actttatagt atttaaaggg 901 agattatatt atatgatggg aggggttctt ccttgggaag caattgaagc ttctattcta 961 aggctggcca cacttgagag ctgcagggcc ctttgctatg gtgtcctttc aattgctctc 1021 atccctgagt tcagagctcc taagagagtt gtgaagaaac tcatgggtct tgggaagaga 1081 aaccagggag atcctttgat gatcattcct gcagcagctc agagggttcc cctactgtca 1141 tcccccagcc gcttcatccc tgaaaactgt ggccagtttg ttatttataa ccacctaaaa 1201 ttagttctaa tagaactcat ttttaactag aagtaatgca attcctctgg gaatggtgta 1261 ttgtttgtct gcctttgtag cagcatctaa ttttgaataa atggatctta ttcg 1 cagtcaggag agagggcagt gagggtccat gctagctggg tcttgagcct cttctggggt 61 tcagtctctg atctacagca gtgtgtccac acctaaaaca tcagctcaga gaggcagttg 121 cttctgctgt tggaaacgga catcccaaaa aaaaacaaaa aacagaaatc aaaagggaag 181 gagaaagtga aagggatgga ggcagcttgt ccccttccct gtgcttgctg ctggtagaaa 241 actcagcctg gaactgaccg cgagcagcagt tcttgagtca attccattcc aacttctaga 301 agattctttt cccgtcgaag agtgtcagga ggagaggcca gacccccttg atcctgatct 361 gccagccact gcatcagata agacgagata accccgagtt cctgttctac cagccctggt 421 gtggtaaccc tctccaatgg ggcaggcttg gaaccctgtg ccaacgaaga tcctcccccg WO 00/09525 PCT/US99/17712 EPT-109 1238 481 tactgataca ggaaggacag cccgggagtg Laccctczac atgggtc:tac ttttatttaa 541 gcaaacartc cctggtcaac aggacgtgta gcattgcccc cccccttagg tcacacagaa 601 aacaggtacc aggaggacaa atagttgctt gcccagggta cagaatgaaa ggcaataggg 661 gactctaggc gaatgttctt cccacccaaa ctgaggtagt aggagaagrc cctactgaag 721 ggaaggtcca gacataatca aaggactacc agagatctcc caggtatcta tagaagtact 781 aacatctcca tccttcaaca actacaggtt acacgtctcc aaggctggga cattgtaaaa 841 cagggccatg gtaaggtcta cccgacagca cagagcaagc ctcccagaag tctgagttcc 901 ttctcctaac ttctcatgct gggatctgag cttcttcgtg aaacacgggg cagaggaggc 961 accagaactc tcctctgacc aactgcccca cagcacacat atcctcaaaa gatagtcttg 1021 aatacgtgat ggaagaatta aagagagtga ggtctgaaga aaatcagccc tctcggggtt 1081 tcctttgggt aactgagtgc taaggtgact tccgagtcag caagaaatat cggacgttca 1141 acccaggttg agtggaggaa acaattattt ctcaatccta atatgttctg gaatagccca 1201 tttatccacg tcattatgac ctgggagtgc gtgaatggaa tccacagatg agggcctctg 1261 tacatagaac agctgtctac ctcaggaaat acaactttta gtattgagaa gctaaaaaga 1321 aaaaaaaatt aaaagagagg tagcccatac taaaaatagc tgtaatgcag aagttcattc 1381 cgaccagttc tttagcgctt acaatgcaaa aaaaagggaa aggaaaaaaa aaaagaaaga 1441 aattaaactc aaaaattgca tggtttagaa gagggaggag gagcctgaat aacaaaaacc 1501 tttgccagga aggccccact gagccttcag tataaaaggg ggaccaaoaaa caggaggtct 1561 acatttagag acttgctctt gcactaccaa agccacaagg cagccttgca gaaaagagag 1621 ctccatcatg cctggctcag cactgctatg ctgcctgctc ttactgactg gcatgaggat 1681 cagcaggggc cagtacagcc gggaagacaa taactgcacc cacttcccag tcggccagag 1741 ccacatgctc ctagagctgc ggactgcctt cagccaggtg aagactttct ttgtaagtat 1801 gagctcgcct agcctttctt cctgccatca cctgaaatat gcattctgat ggaactgcaa 1861 aaatagctct ccttctcctc ctccttctcc tccttctctt tctcctcctc tgctttctcc 1921 tccttctctt cctcctcctt ctcttcttcc tcctctccct cttcctcctc cagctcttac 1981 ctcatgctgc tcctccccta tttccagcac ctattaccct taaacttaaa tctagagagt 2041 cctagggaaa gccatgagtt aaactaaacc caggcacatc cgaaaagcta actaggaggt 2101 gaatgcattg tctctcccac gctcaagaac tttctgttaa gtttccaata aggctccatg 2161 ttttgctggc taggacaaaa gtctgtggtc tctgcgtagt ctctagatct gggggacaga 2221 ggtttggggg tttgaagcag caccagcata gagagcttgc attacaaaag tattcccctt 2281 tcagagctcc tggaactggt atggaggtcc aaagaaggca gagagctatg caaaacaggc 2341 tttctataag ggactccaga aaggaagggt tgacacaggt gctcttgaaa cctgatctga 2401 ctcatctgaa agaagaccgg gcctgggtct aacttctccc agtcagttaa attcagtcag 2461 aagtttttaa aaacaactgg atcccaagag gaaggacttt gatttaactc cgggctctag 2521 cactgtcaaa tcctgttctt aaaactctcc tttccacagt tgccagggca tttgaattga 2581 ttacaaattc aaaactctac aaatggaaaa gtattcaaat gacatgcaca ttgggtattt 2641 tccccagtcc ttgcattcac gttctttatg ttcttccagc aaacaaagga ccagctggac 2701 aacatactgc taaccgactc cttaatgcag gactttaagg taagagtccg gtgggtgctg 2761 gggagcgacc aagcgattag ggacgggacg ggaggtgctg cttgtgacag cagagctggg 2821 tctgatgcct tgactttcaa aaagagaagt gagaagacct tgactcagca tatcgccagc 2881 agtcaagggt tgtgaagagc tcattctgtg gtaaagggag aaaatgtaac tagaaggggc 2941 ggggatgggg ggggggtccc taggaacaqg acagtccatc aaggttagca gcaacagatc 3001 accattccag taagtcacac ccaacctctg atccctgcct ctagggttac ttgggttgcc 3061 aagccttatc ggaaatgatc cagttttacc tggtagaagt gatgccccag gcagagaagc 3121 atggcccaga aatcaaggag catttgaatt ccctgggtga gaagctgaag accctcagga 3181 tgcggctgag gcgctgtgtg agtagcagat gcgttcttcc ccacccccaa tccccttaga 3241 gccacccaac aaatactgtc tcctacagcc cagtcaggcc acatgcatcc agagacacac 3301 acagactaga caggagacta ggtaaaccta gagagacgcc tgtccggtgt cgggtctctt 3361 gctcatctgt ctctgagcga gtgtgggagt gactttgagg cactcacacg tgaagatttg 3421 cgcatagcct tcctgttatt tgtgagtcat tgtgggttat tagctactcc cctctctctc 3481 catgggaagg ctggggcttc agtcatggct ccctcacctc tgggctgcca gctgaggctc 3541 ccaagcacag gaaaacattc atctctttat ctcatctttt gggaagcaaa ttcagtggca 3601 cagagctggg ctgacaggac gctggtgttt cagaagggcc agaagactgc tatccctaag 3661 ccagtatcta tgaataatac agtcggggca tctatgtctc tgaagcgatg ccttggctgc 3721 tcttgttttt cttacttctc tcactgatac tgggacatca gctggagtct acttgtgcaa 3781 cggttctggc ctgacgattt ggccccagta gctgagactt tcgctcctct ctcagacacc 3841 tagaaatagt tcatggtggt tgagattgga gatagacaag aagagacact aaaaacagaa 3901 caggtgcctt ggagctctga gagacaaaac ccgagacctg agttcacacc cacacttagc 3961 aagccatctt agtgattgca aagacataca ttgcatcttt ctaggctgtc ctctgctgtc 4021 cccctcagtc cctaccgaaa tagataagga ccaatcacgg ctcagttctc cctgggagct 4081 aagaagtggg cattgaagat gagcaagggt gtctccttcc tcacacaaca agatagtttc 4141 ccccaagtac catggatgca gaattcaagc aagaattacc aatgctctct tttttcttct 4201 tcagcatcga tttctcccct gtgaaaataa gagcaaggca gtggagcagg tgaagagtga 4261 ttttaataag gtaagtggca aagggggcga gtgtaacaag acctctgtct actcaccaaa 4321 gcgcagaagg agggcgggag ctattctgca cctggagtgt gggaacccag caaatggtgt 4381 gacctcctct gccagttaga aagccaccac ctcagttaca tttgttttct gcaaagcgtc 4441 tctggcagtt tctaaatgac tgctccactt ttgcaggctt ttggcttaga ctgaccagac 4501 agcctatgag cacagggcac taggtgttga ggagagtgac ataggaaaca gaaagtacag 4561 aaagtacctt gttgggaaac aggctgaacc cacaagtaca gaaagcagac atgaattaat 4621 ttactcaggt acatcattgg ggctcagcct ggatgcccct cccccaaatc agaacgagca 4681 gaaagcagaa ttcttacttg tcccggggca ctttccacct ggcaaacaaa atgaggtttc 4741 acacttccaa ctgcctgtga acctattcaa ccctagttcc cagaagccat gtggcctaca 4801 tcatcatctt tgtgggctaa gcagagacac ctggcagggc tctaacatta gtgggcatga 4861 attccatgac agcaggtcag agctgcaggg tgaggactgc ctacacactc aaaacataaa 4921 aaaaaaaaaa aaaaaacacc aaccatttcc ctgctatctc tatcactgcc ctgcttacaa WO 00/09525 PCT/US99/17712 EPI-109 1239 4981 aczgcccct ctggcatctt tgcataacat tctgcataag cattatataa gcactggcct 5041 cttaaaaaaa attagttgaa aaggtgccac cctgaagaca gtgctttggg gactgaatgc 5101 ttcccttgct gactcctggc agtgcttaaa gctgggagaa ggttggtccc accacatcct 5161 gactactaca gratagttgt ctctcttctt tcatttccct gtccccattt ctttattgta 5221 cataaagtaa ctggtgtatg tgcacacaca tagtgctctc tctttctttt ccttttttaa 5281 actaaacggc cgatgttctg ttctggttgg catcagatgg agatggtctg ggggaaagta 5341 ctgggtttgt gaaaataccc ccttctccat tagtggcatg ctctttcagc tcttatcttt 5401 atattccagt aagttatttt gctctcattg ttttaacaaa agaacccaac aacaccaaat 5461 ctttgcatac cttgttcgat tggagaattt taatgttttt catttatcat tgtaaaaccg 5521 aggacaattt tataactttt ttgtacgtgg ctgttacatg tagggcaatc tgtctttaag 5581 tagggataaa ttactcttga ataaaatgat cctagatagt tttcccttca agtcaagcgt 5641 cttgttgttt aaataaactt cttgtttaaa atgaaaaaaa aaaaaacaaa caaacaaaaa 5701 aaagctggga gaaggtatag gagaaacagg ggaaggcacg gccccttccc aaagcagacg 5761 gacaaatctt tgggtccttc agctcccaac acaagaaagc agagatcttt ctatgctcag 5821 catccttccc agggcaggga gcccctcagc ccaccaatgg gtactaacca gatgcttctc 5881 tccccacaca gctccaagac caaggtgtct acaaggccat gaatgaattt gacatcttca 5941 tcaactgcat agaagcatac atgatgatca aaatgaaaag ctaaaacacc tgcagtgtgt 6001 attgagtctg ctggactcca ggacctagac agagctctct aaatctgatc cagggatctt 6061 agctaacgga aacaactcct tggaaaacct cgtttgtacc tctctccgaa atatttatta 6121 cctctgatac ctcagttccc attctattta ttcactgagc ttctctgtga actatttaga 6181 aagaagccca atattataat tttacagtat ttattatttt taacctgtgt ttaagctgtt 6241 tccattgggg acactttata gtatttaaag ggagattata ttatatgatg ggaggggttc 6301 ttccttggga agcaattgaa gcttctattc taaggctggc cacacttgag agctgcaggg 6361 ccctttgcta tggtgtcctt tcaattgctc tcatccctga gttcagagct cctaagagag 6421 ttgtgaagaa actcatgggt cttgggaaga gaaaccaggg agatcctttg atgatcattc 6481 ctgcagcagc tcagagggtt cccctactgt catcccccag ccgcttcatc cctgaaaact 6541 gtggccagtt tgttatttat aaccacctaa aattagttct aatagaactc atttttaact 6601 agaagtaatg caattcctct gggaatggtg tattgtttgt ctgcctttgt agcagactct 6661 aattttgaat aaatggatct tattcgaatt acagtgtggt gtctattgag ttctgtctga 6721 tttaaaagaa aaatccctta aaattccaga gggcagaagc agtgaatctt agactccaca 6781 aaaagaatgc cagcaacctc tccaggaagg ggttgagctc ggatcagatc agaggaaagt 6841 cttgcctggc tttcaaagca tcagcataaa ctactgatat cttcaagctc agtcctttaa 6901 aatgtgtcct gaaaccttaa aaggcattct accttccaaa gctagggaag gtgattctaa 6961 gtaaccatcg gaaggaagtg ggaagcatca aagctgaaac tctgagacga aatgttgggg 7021 ttaaaaatgg aagctagggg caggagggtg gggagatggc tcagcagtta gagtgtgtgc 7081 cggcaccagt gagacaggag ttcatatcct tggaatccaa ccaacacaca accaacacta 7141 ggcaagagat gcctaatgtg tcagtggttg cttcaagctc cagaggtcct ggggtgaact 7201 tagatcc (2) INFORMATION FOR SEQ ID NO:70: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 3632 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQtJENCE DESCRIPTION: SEQ ID NO:70: 1 aaagagctgg aggcgcgcag gccggctccg ctccggcccc ggacgatgcg gcgcgcccag 61 gatgctgccg tgcctcgtag tgctgctggc ggcctcctc agcctccgtc ttggctcaga 121 cgctcatggg acagagctgc ccagccctcc gtctgtgtgg tttgaagcag aatttttcca 181 ccacatcctc cactggacac ccatcccaaa tcagtctgaa agtacctgct atgaagtggc 241 gctcctgagg tatggaatag agtcctggaa ctccatctcc aactgtagcc agaccctgtc 301 ctatgacctt accgcagtga ccttggacct gtaccacagc aatggctacc gggccagagt 361 gcgggctgtg gacggcagcc ggcactccaa ctggaccgtc accaacaccc gcttctctgt 421 ggatgaagtg actctgacag ttggcagtgt gaacctagag atccacaatg gcttcatcct 481 cgggaagatt cagctaccca ggcccaagat ggcccccgcg aatgacacat atgaaagcat 541 cttcagtcac ttccgagagt atgagattgc cattcgcaag gtgccgggaa acttcacgtt 601 cacacacaag aaagtaaaac atgaaaactt cagcctccta acctctggag aagtgggaga 661 gttctgtgtc caggtgaaac catctgtcgc ttcccgaagt aacaagggga tgtggtctaa 721 agaggagtgc atctccctca ccaggcagta tttcaccgtg accaacgtca tcatcttctt 781 tgcctttgtc ctgctgctct ccggagccct cgcctactgc ctggccctcc agctgtatgt 841 gcggcgccga aagaagctac ccagtgtcct gctcttcaag aagcccacc ccttcatctt 901 catcagccag cgtccctccc cagagaccca agacaccatc cacccgcttg atgaggaggc 961 ctttttgaag gtgtccccag agctgaagaa cttggacctg cacggcagca cagacagtgg 1021 ctttggcagc accaagccat ccctgcagac tgaagagccc cagttcctcc tccctgaccc 1081 tcacccccag gctgacagaa cgctgggaaa cggggagccc cctgtgctgg gggacagctg 1141 cagtagtggc agcagcaata gcacagacag cgggatctgc ctgcaggagc ccagcctgag 1201 ccccagcaca gggcccacct gggagcaaca ggtggggagc aacagcaggg gccaggatga 1261 cagtggcatt gacttagttc aaaactctga gggccgggct ggggacacac agggtggctc 1321 ggccttgggc caccacagtc ccccggagcc tgaggtgcct ggggaagaag acccagctgc 1381 tgtggcattc cagggttacc tgaggcagac cagatgtgct gaagagaagg caaccaagac 1441 aggctgcctg gaggaagaat cgcccttgac agatggcctt ggccccaaat tcgggagatg 1501 cctggttgat gaggcaggct tgcatccacc agccctggcc aagggctatt tgaaacagga 1561 tcctctagaa atgactctgg cttcctcagg ggccccaacg ggacagtgga accagcccac 1621 tgaggaatgg acactcctgg ccttgagcag ctgcagtgac ctgggaatat ctgactggag 1681 ctttgcccat gaccttgccc ctctaggctg tgtggcagcc ccaggtggtc tcctgggcag WO 00/09525 PCT/US99/17712 EPI-109 1240 1741 ctttaactca gacctggtca ccctgcccct catctctagc ctgcagtcaa gtgagtgact 1801 cgggctgaaa ggctgctttt gatttagcc atgcctgctc ctctgcctgg accaggagga 1861 gggccctagg gcagaagta ggcacgaggc agtctgggca cttttctgca agtccactgg 1921 ggctggccca gccaggctgc agggctggtc aggqtgtctg gggcaggagg aggccaactc 1981 actgaactag tgcagggtat gtgggtggca ctgacctgtt ctgttgactg gggccctgca 2041 gactctggca gagctgagaa gggcagggac cttctccctc ctaggaactc tttcctgtat 2101 cataaaggat tatttgctca ggggaaccat ggggctttct ggagttgtgg tgaggccacc 2161 aggctgaagt cagctcagac ccagacctcc ctgcttaggc cactcgagca tcagagcttc 2221 cagcaggagg aagggctgta ggaatggaag cttcagggcc ttgctgctgg ggtcattttt 2281 aggggaaaaa ggaggatatg atggtcacat ggggaacctc ccctcatcgg gcctctgggg 2341 caggaagctt gtcactggaa gatcttaagg tatatatttt ctggacactc aaacacatca 2401 taatggattc actgagggga gacaaaggga gccgagaccc tggatggggc ttccagctca 2461 gaacccatcc ctctggtggg tacctCtggc acccatctgc aaatatctcc ctctctccaa 2521 caaatggagt agcatccccc tggggcactt gctgaggcca agccactcac atcctcactt 2581 tgctgcccca ccatcttgct gacaacttcc agagaagcca tggttttttg tattggtcat 2641 aactcagccc tttgggcggc ctctgggctt gggcaccagc tcatgccagc cccagagggt 2701 cagggttgga ggcctgtgct tgtgtttgct gctaatgtcc agctacagac ccagaggata 2761 agccactggg cactgggctg gggtccctgc cttgttggtg ttcagctgtg tgattttgga 2821 ctagccactt gtcagagggc ctcaatctcc catctgtgaa ataaggactc cacctttagg 2881 ggaccctcca tgtttgctgg gtattagcca agctggtcct gggagaatgc agatactgtc 2941 cgtggactac caagctggct tgtttcttat gccagaggct aacagatcca atgggagtcc 3001 atggtgtcat gccaagacag tatCagacac agccccagaa gggggcatta tgggccctgc 3061 ctccccatag gccatttgga ctctgccttc aaacaaaggc agttcagtcc acaggcatgg 3121 aagctgtgag gggacaggcc tgtgcgtgcc atccagagtc atctcagccc tgcctttctc 3181 tggagcattc tgaaaacaga tattctggcc cagggaatcc agccatgacc cccacccctc 3241 tgccaaagta ctcttaggtg ccagtctggt aactgaactc cctctggagg caggcttgag 3301 ggaggattcc tcagggttcc cttgaaagct ttatttattt attttgttca tttatttatt 3361 ggagaggcag cattgcacag tgaaagaatt ctggatatct caggagcccc gaaattctag 3421 ctctgacttt gctgtttcca gtggtatgac cttggagaag tcacttatcc tcttggagcc 3481 tcagtttcct catctgcaga ataatgactg acttgtctaa ttcataggga tgtgaggttc 3541 tgctgaggaa atgggtatga atgtgccttg aacacaaagc tctgtcaata agtgatacat 3601 gttttttatt ccaataaatt gtcaagacca ca (2) INFORMATION FOR SEQ ID NO:71: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1696 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:71: 1 gctgtagctg gtgagaggaa gtcctagagg ctatggacac tctgctgctg ggatcaccga 61 gatgagcagc agctgctcag ggctgagcag ggtcctggtg gccgtggcta cagccctggt 121 gtctgcctcc tccccctgcc cccaggcctg gggcccccca ggggtccagt atgggcagcc 181 agggaggtcc gtgaagctgt gttgtcctgg agtgactgcc ggggacccag tgtcctggtt 241 tcgggatggg gagccaaagc tgctccaggg acctgactct gggctagggc atgaactggt 301 cctggcccag gcagacagca ctgatgaggg cacctacatc tgccagaccc tggatggtgc 361 acttgggggc acagtgaccc tgcagctggg ctaccctcca gcccgccctg ttgtctcctg 421 ccaagcagcc gactatgaga acttctcttg cacttggagt cccagccaga tcagcggttt 481 acccacccgc tacctcacct cctacaggaa gaagacagtc ctaggagctg atagccagag 541 gaggagtcca tccacagggc cctggccatg cccacaggat cccctagggg ctgcccgctg 601 tgttgtccac ggggctgagt tctggagcca gtaccggatt aatgtgactg aggtgaaccc 661 actgggtgcc agcacacgcc tgctggatgt gagcttgcag agcatcttgc gccctgaccc 721 accccagggc ctgcgggtag agtcagtacc aggttacccc cgacgcctgc gagccagctg 781 gacataccct gcctcctggc cgtgccagcc ccacttcctg ctcaagttcc gtttgcagta 841 ccgtccggcg cagcatccag cctggtccac ggtggagcca gctggactgg aggaggtgat 901 cacagatgct gtggctgggc tgccccatgc tgtacgagtc agtgcccggg actttctaga 961 tgctggcacc tggagcacct ggagcccgga ggcctgggga actccgagca ctgggaccat 1021 accaaaggag ataccagcat ggggccagct acacacgcag ccagaggtgg agcctcaggt 1081 ggacagccct gctcctccaa ggccctccct ccaaccacac cctcggctac ttgatcacag 1141 ggactctgtg gagcaggtag ctgtgctggc gtctttggga atcctttctt tcctgggact 1201 ggtggctggg gccctggcac tggggctctg gctgaggct agacggggtg ggaaggatgg 1261 atccccaaag cctgggttct tggcctcagt gattccaqtg gacaggcgtc caggagctcc 1321 aaacctgtag aggacccagg agggcttcgg cagattccac ctataattct gtcttgctgg 1381 tgtggataga aaccaggcag gacagtagat ccctatggtt ggatctcagc tggaagttct 1441 gtttggagcc catttctgtg agaccctgta tttcaaattt gcagctgaaa ggtgcttgta 1501 cctctgattt caccccagag ttggagttct gctcaaggaa cgtgtgtaat gtgtacatct 1561 qtgtccatgt gtgaccatgt gtctgtgaag gccagggaac atgtattcct ctgcatgcat 1621 gtatgtaggt gcctgggagt gtgtgtggtc cttgctctgg ccctttccct tgcagggttg 1681 tgcaggtgtg aataaa (2) INFORMATION FOR SEQ ID NO:72: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1682 base pairs (B) TYPE: nucleic acid (C) STRANOEDNESS: single WO 00/09525 PCT/US99/17712 EPI-109 1241 (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:72: 1 ggaagatgag cagcagctgc tcagggctaa gcagggzct ggtggccgtg gctacagccc 61 tggtgtctgc ctcctcccc tgcccccagg cctgagggccc cccaggggtc cagtatgggc 121 agccaggcag gtccgtgaag ctgtgttgtc ctggagtgac tgccggggac ccagtgtcct 181 ggtttcggga tggggagcca aagctgctcc agggacctua ctctgggcta gggcatgaac 241 tggtcctggc ccaggcagac aacactgatg agggcaccta catctgccag accctggatg 301 gtgcacttgg gggcacaqta accctgcagc zgggctaccc tccagcccgc cctgttgtct 361 cctgccaagc agccgactat aagaacttct cttgcacttg gagtcccagc cagatcagcg 421 gtttacccac ccgctacctc acctcctaca agaagaagac agtcctagga gctgatagcc 481 agaggaggag tccatccaca gggccctggc catgcccaca ggatccccta ggggctgccc 541 gctgtgttgt ccacggggct aagttctgga gccagtaccg gattaatgtg actgaggtga 601 acccactggg tgccagcaca cgcctgctgg atatgagctt gcagagcatc ttgcgccctg 661 acccacccca gggcctoag gtagagtcag taccaggtta cccccgacgc ctgcgagcca 721 gctggacata ccctgcctcc tggccgtgcc agccccaczt cctgctcaag ttccgtttgc 781 agtaccgtcc ggcgcagcat ccagcctggt ccacggtgga gccagctgga ctggaggagg 841 tgatcacaga tgctgtggct aggctgcccc atgctgtacg agtcagtgcc cgggactttc 901 tagatgctgg cacctggagc acctggagcc cggaggcctg gggaactccg agcactggga 961 ccataccaaa ggagatacca gcatggggcc agctacacac gcagccagag gtggagcctc 1021 aggtggacag ccctgctcct ccaaggccct ccctccaacc acaccctcgg ctacttgatc 1081 acagggactc tgtggagcag gtagctgtgc tggcgtcttt gggaatcctt tctttcctgg 1141 gactggtggc tggggcccta gcactggggc tctggctgag gctgagacgg ggtgggaagg 1201 atggatcccc aaagcctggg ttcttggcct cagtgattcc agtggacagg cgtccaggag 1261 ctccaaacct gtagaggacc caggagggct tcggcagatt ccacctataa ttctgtcttg 1321 ctggtgtgga tagaaaccag gcaggacagt agatccctat ggttggatct cagctggaag 1381 ttctgtttgg agcccatttc tgtgagaccc tgtatttcaa atttgcagct gaaaggtgct 1441 tctacctctg atttcacccc agagttggag ttctgctcaa ggaacgtgtg taatgtgtac 1501 atctgtgtcc atgtgtgacc atgtgtctgt gaggcaggga acatgtattc tctgcatgca 1561 tgtatgtagg tgcctgggga gtgtgtgtgg gtccttggct cttggccttt ccttgcaggg 1621 gttgtgcagg tgtgaataaa gagaataagg aagttcttgg agattatact cagaaaaaaa 1681 aa (2) INFORMATION FOR SEQ ID NO:73: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 413 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:73: 1 tctgtggagc aggtagctgt gctggcgtct ttgggaatcc tttctttcct gggactggtg 61 gctggggccc tggcactggg gctctggtaa gtgactgcca ttggtccctc agcctctgat 121 cctcacacat gctctgatgc ccatagacca cattcatctc cacccttcat gactgcctgc 181 tgaacctgtc tgattctgga actacctccc catacctcca tcccctatgc cccacttgat 241 tttaactgat tcctctcctg accctttact aataaaccct ttggcggaga ctgagataac 301 ccacattgtt ggagagacag ctgcctttct atgccccagg ctgaggctga gacggggtgg 361 gaaggatgga tccccaaagc ctgggttctt ggcctcagtg attccagtgg aca (2) INFORMATION FOR SEQ ID NO:74: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 3791 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:74: 1gctgtagctg gtgagaggaa gtcctagagg ctatggacac tctgctgctg ggatcaccga 61 gatgagcagc agctgctcag ggctgagcag ggtcctggtg gccgtggcta cagccctggt 121 gtctgcctcc tccccctgcc cccaggcctg gggcccccca ggggtccagt atgggcagcc 181 agggaggtcc gtgaagctgt gttgtcctgg agtgactgcc ggggacccag tgtcctggtt 241 tcgggatggg gagccaaagc tgctccaggg acctgactct gggctagggc atgaactggt 301 cctggcccag gragacagca ctgatgaggg cacctacatc tgccagaccc tggatggtgc 361 acttgggggc acagtgaccc tgcagctggg ctaccctcca gcccgccctg ttgtctcctg 421 ccaagcagcc gactatgaga acttctcttg cacttggagt cccagccaga tcagcggttt 481 acccacccgc tacctcacct cctacaggaa gaagacagtc ctaggagctg atagccagag 541 gaggagtcca tccacagggc cctggccatg cccacaggat cccctagggg ctgcccgctg 601 tgttgtccac ggggctgagt tctggagcca gtaccggatt aatgtgactg aggtgaaccc 661 actgggtgcc agcacacgcc tgctggatgt gagcttgcag agcatcttgc gccctgaccc 721 accccagggc ctgcgggtag agtcagtacc aggttacccc cgacgcctgc gagccagctg 781 gacataccct gcctcctggc cgtgccagcc ccacttcctg ctcaagttcc gtttgcagta 841 ccgtccggcg cagcatccag cctggtccac ggtggagcca gctggactgg aggaggtgat 901 cacagatgct gtggctgggc tgccccatgc tgtacgagtc agtgcccggg actttctaga 961 tgctggcacc tggagcacct ggagcccgga ggcctgggga actccgagca ctgggaccat 1021 accaaaggag ataccagcat ggggccagct acacacgcag ccagaggtgg agcctcaggt 1081 ggacagccct gctcctccaa ggccctccct ccaaccacac cctcggctac ttgatcacag 1141 ggactctgtg gagcaggtag ctgtgctggc gtctttggga atcctttctt tcctgggact 1201 ggtggctggg gccctggcac tggggctctg gctgaggctq agacggggtg ggaaggatgg WO 00/09525 PCT/US99/17712 EPI-109 1242 1261 atccccaaag cctgggct tggcctcagt gattccagtg gacaggcgrc caggagcrcc 1321 aaacctazag aggacccagg agggcttcgg cagattCCac ctataa-tct gtcttgctgg 1381 tgtggataga aaccaggcag gacagtagat ccctatggrt ggaccagc tggaagttct 1441 gtttggagcc catttctgtg agaccctgta tttcaaattt gcagctgaaa ggtgcttgta 1501 cctctgattt caccccagag ttggagttct gctcaaggaa cgtgtgtaat gtgtacatct 1561 gtgtccatat gtgaccatgt gtctgtgaag gccagggaac atgtattccz ctgcatgcat 1621 gtatgtaggt gcctgggagt gtgtgtggtc cttgctctgg ccctttccct tgcagggttg 1681 tgcaggtgtg aataaa I ggaagatgag cagcagctgc tcagggctga gcagggtcct ggtggccgtg gctacagccc 61 tggtgtctgc ctcctccccc tgcccccagg cctggggccc cccaggggtc cagtatgggc 121 agccaggcag gccgtgaag ctgtgttgtc ctggagtgac tgccggggac ccagtgtcct 181 ggtttcggga tggggagcca aagctgctcc aggaCCtga ctCtgggcta gggcatgaac 241 tggtcctggc ccaggcagac agcactgatg agggcaccta catctgccag accctggatg 301 gtgcacttgg gggcacagtg accctgcagc tgggctaccc tccagcccgc cctgttgtct 361 cctgccaagc agccgactat gagaacttct cttgcacttg gagtcccagc cagatcagcg 421 gtttacccac ccgctacctc acctcctaca ggaagaagac agtcctagga gctgatagcc 481 agaggaggag tccatccaca gggccctggc catgcccaca ggatCcccta ggggctgccc 541 gctgtgttgt ccacggggct gagttctgga gccagtaccg gattaatgtg actgaggtga 601 acccactggg tgccagcaca cgcctgctgg atgtgagctt gcagagcatc ttgcgccctg 661 acccacccca gggcctgcgg gtagagtcag taccaggtta cccccgacgc ctgcgagcca 721 gctggacata ccctgcctcc tggccgtgcc agccccactt cctgctcaag ttccgtttgc 781 agtaccgtcc ggcgcagcat ccagcctggt ccacggtgga gccagctgga ctggaggagg 841 tgatcacaga tgctgtggct gggctgcccc atgctgtacg agtcagtgcc cgggactttc 901 tagatgctgg cacctggagc acctggagcc cggaggcctg gggaactccg agcactggga 961 ccataccaaa ggagatacca gcatggggcc agotacacac gcagccagag gtggagcctc 1021 aggtggacag ccctgctcct ccaaggccct ccctccaacc acaccctcgg ctacttgatc 1081 acagggactc tgtggagcag gtagctgtgc tggcgtcttt gggaatcctt tctttcctgg 1141 gactggtggc tggggccctg gcactggggc tctggctgag gctgagacgg ggtgggaagg 1201 atggatcccc aaagcctggg ttcttggcct cagtgattcc agtggacagg cgtccaggag 1261 ctccaaacct gtagaggacc caggagggct tcggcagatt ccacctataa ttctgtcttg 1321 ctggtgtgga tagaaaccag gcaggacagt agatccctat ggttggatct cagctggaag 1381 ttctgtttgg agcccatttc tgtgagaccc tgtatttcaa atttgcagct gaaaggtgct 1441 tctacctctg atttcacccc agagttggag ttctgctcaa ggaacgtgtg taatgtgtac 1501 atctgtgtcc atgtgtgacc atgtgtctgt gaggcaggga acatgtattc tctgcatgca 1561 tgtatgtagg tgcctgggga gtgtgtgtgg gtccttggct cttggccttt ccttgcaggg 1621 gttgtgcagg tgtgaataaa gagaataagg aagttcttgg agattatact cagaaaaaaa 1681 aa 1 tctgtggagc aggtagctgt gctggcgtct ttgggaatcc tttctttcct gggactggtg 61 gctggggccc tggcactggg gctctggtaa gtgactgcca ttggtccctc agcctctgat 121 cctcacacat gctctgatgc ccatagacca cattcatctc cacccttcat gactgcctgc 181 tgaacctgtc tgattctgga actacctccc catacctcca tcccctatgc cccacttgat 241 tttaactgat tcctctcctg accctttact aataaaccct ttggcggaga ctgagataac 301 ccacattgtt ggagagacag ctgcctttct atgccccagg ctgaggctga gacggggtgg 361 gaaggatgga tccccaaagc ctgggttctt ggcctcagtg attccagtgg aca (2) INFORMATION FOR SEQ ID NO:75: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 762 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:75: 1 atgtggcccc ctgggtcagc ctcccagcca ccgccctcac ctgccgcggc cacaggtctg 61 catccagcgg ctcgccctgt gtccctgcag tgccggctca gcatgtgtcc agcgcgcagc 121 ctcctccttg tggctaccct ggtcctcctg gaccacctca gtttggccag aaacctcccc 161 gtggccactc cagacccagg aatgttccca'tgccttcacc actcccaaaa cctgctgagg 241 gccgtcagca acatgctcca gaaggccaga caaactctag aattttaccc ttgcacttct 301 gaagagattg atcatgaaga tatcacaaaa gataaaacca gcacagtgga ggcctgttta 361 ccattggaat taaccaagaa tgagagttgc ctaaattcca gagagacctc tttcataact 421 aatgggagtt gcctggcctc cagaaagacc tcttttatga tggccctgtg ccttagtagt 481 atttatgaag acttgaagat gtaccaggtg gagttcaaga ccatgaatgc aaagcttctg 541 atggatccta agaggcagat ctttctagat caaaacatgc tggcagttat tgatgagctg 601 atgcaggccc tgaatttcaa cagtgagact gtgccacaaa aatcctccct tgaagaaccg 661 gatttttata aaactaaaat caagctctgc atacttcttc atgctttcag aattcgggca 721 gtgactattg atagagtgat gagctatctg aatgcttcct aa (2) INFORMATION FOR SEQ ID NO:76: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 2056 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:76: aagcttcttt tgcataactg gcgctggatt tttactgaga ctttacgtta cattttttt 61 tttttaaatt tcaaggtgct ttacgaaca catgaataaa atattttgt cattttgaac WO 00/09525 PCT/US99/17712 EPI-109 1243 121 ctzacttatc ttattttatg catgtattta tttatggggg ggcacaaaga ctcatctgtg 181 gtagtgcagc cactgtaaat aaattagtga aactacttca cgtcaattC tgttcagtac 241 actttagtga tggatcggag gaaattaata catgtttaca aaaagccccz cccccagttg 301 ttacatatgc ctcagagata ccagttgtga aaagtgcagg tgcacttaca cacatacgca 361 cacacacccc acaaatggta tcatacgaaa aaacatacct gcaatctgat ttgtccactt 421 aattgtatat cttggataca gaacttgttt cactggaagg ctaaaaggca aagtctgggg 481 aggcctagag gacacagggg atgggaggag gcgctctgag ctggatgtaa ggtctccacc 541 cacggccaga gcacaaggtc ggataaccag tgggcctgcc ggcttggctg cctgggccct 601 cccctgccga gacaaacggc tggagggagg aagtgtgcgg ctgggaagct ccgctgctct 661 ggcccgggtt tcccatttcc cccttcccgc gctgagacgg cgaggaaagt tagcccggaa 721 atctgcgccc gcctaaaacc cggcctggtc ccagccaccg ccccaggaac ttcccccacc 781 gcaggggcgg aggtcgagag cagggatgga gaagtggacc tgcgcgggtg gactccgggg 841 cgcgggtgga ctccggggcg cggggggact ccgaggagcg ggtggactgt ggggcgcggg 901 taccgtctca cagcgacctc tgtcggcggc tctggggatg gcccgcatct gtctgcgtgt 961 acctggtata cgtgcaggta catgttcctg ttcacgtgca gactgggcgg gggatggggg 1021 ggcccacacc ggtgtacacc tttgcatacc tcttagcaac ttgaaattcc accacgagag 1081 atatctttat tccgctattc ctgtgcatct gcacggagcc cctagggcca tagatttgtg 1141 tgcaaatgaa atgaggatgt agtctgggtg cccaaggggg ggtgccttga gtgtggttgt 1201 ctgtatgcct ccctgagggt atttcacttt ctgctcccat ccgcccctat gagcgagtac 1261 ctatgagcac aggatgtgca catatttgag tcttattagt ggtacacgca gttttatcat 1321 ctccccaggt ctgtgtctgt atgaaatgtg catgggtgtg tgtgtgcacg cgtgtgttcc 1381 cactcgggga atgtggggag aggtgcatgg agccaaqatg ggtggtaaat agtatgtttc 1441 tgaaattaaa ggactaatgt ggaggaaggc gccccagatg tactaaaccc tttgccttca 1501 tctcatcctc tctgacttgg gaagaaccag gattttgttt ttaagccctt gggcatacag 1561 ttgttccatc ccgacatgaa ctcagcctcc cgtctgaccg ccccttggcc ttccttcttc 1621 ctcgatctqt ggaacccagg gaatctgcct agtgctgtct ccaagcacct tggccatgat 1681 gtaaacccag agaaattagc atctccatct ccttccttat tccccaccca aaagtcattt 1741 cctcttagtt cattacctgg gattttgatg tctatgttcc ctcctcgtta ttgatacaca 1801 cacagagaga gacaaacaaa aaaggaactt cttgaaattc ccccagaagg ttttgagagt 1861 tgttttcaat gttgcaacaa gtcagtttct agtttaagtt tccatcagaa aggagtagag 1921 tatataagtt ccagtaccag caacagcagc agaagaaaca acatctgttt cagggccatt 1981 ggactctccg tcctgcccag agcaaggtaa gcacttccca agcccctacc tccctcccct 2041 ccctgtgggc ctgcag (2) INFORMATION FOR SEQ ID NO:77: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1703 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:77: 1 gaattctcag acagcagcat tagaaggggc cttagagatc aaccatttct cttattttac 61 acacacctaa aactccctac agccgtgctt catcagcttc gagcagatga gccacccaga 121 aggcagctcc agttattagg tcctagggcc tgggtgtagt caggcccttt ggaagctcca 181 agtcagagat caaacacatc ctccccacta cccacgccta gggtqactaa tgcctgtggg 241 aaaaacaact gaactaaaaa gtcccacagg aacctcaaac ccagcacatc caaaatggaa 301 cttctcacca tctcctccaa actcagtcct cttatacagt aatccctgta aagctagaac 361 aatctccatt ccccattctc agggccttcc tctcccgctc acctgaggag ctaccaagcc 421 ttggcccaca agccctctga gagtccctcc tgcccaccct gtgttctcca tactgaataa 481 ggacttggcc acaccttgtc aactcttccc tctgctctac tcctgacccc tggatccccc 541 catcatgcaa attctgccac atctcccgcc taaaacccag gaagactccc cactactctc 601 agcacagaaa gtacactcct tagtatggca tcccctgccc tcatggcatg gcccatccag 661 ccctccagcc tcacaccctg caaggacacc tagaccccca cctccctcaa cccttcatga 721 ctgcgcttct gatccctgtt tcccctggct agaccctgcg tgccctcccg ctggaagcgg 781 tctaatgcct gcttgttttt aacactcagg ttggggcccc tgcctgctcc cgggagcctt 841 tgctgactcc tggaccccgt tgctccggct gagcgtgggc tctttctcta ggtctttcct 901 cccaggactc tgtgtattca tcctatcgtt aaactggatt ctctacaaga gtaataattg 961 cagagtcagc cagctctcat cccttttcag gtttcagaaa agacctgtga acaaaacgcc 1021 ttgagtctga tttagtgtgg caatgcccca agggtcctgt tctccctggg tgtcctgcac 1081 ctggtgcaac gtcggcctgg catctagtga gccatctaaa ggaacgatga tgagtgaatg 1141 atttgcctac cccttccagt actaggctgg aggtcgtggt tagggcccat ccctacgcag 1201 gacatgcaaa gtgggaggca ctcctctctc tacgtcggca gggggcgctg cacagctgcg 1261 gggcggggta gcttagacac ggggcgtccg gctaaggccg gggacccagg gtggtgggcg 132.1 gggtgtcccg cccgcctgtg gaccccgcgc agtaactgcg aacatttcgc tttcattttg 1381 ggccgagctg gaggcggcgg ggccgtcccg gaacggctgc ggccgggcac cccgggagtt 1441 aatccgaaag cgccgcaagc ccccggggcc ggccgcaccg cacgtgtcac cgagaagctg 1501 atgtagagag agacacagaa ggagacagaa agcaagagac cagagtcccg ggaaagtcct 1561 gccgcgcctc gggacaatta taaaaatgtg gccccctggg tcagcctccc agccaccgcc 1621 ctcacctgcc gcggccacag gtctgcatcc agcggctcgc cctgtgtccc tgcagtgccg 1681 gctcagcata tgtccagcgc gca (2) INFORMATION FOR SEQ ID NO:78: (1) SEQUENCE CHARACTERISTICS: (A) LENGTH: 4521 base pairs (B) TYPE: nucleic acid WO 00/09525 PCT/US99/17712 EPI-109 1244 (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:78: 1 atgtggcccc ctgggtcagc ctcccagcca ccgccctcac ctgccgcggc cacaggtctg 61 catccagcgg ctcgccctat gtccctgcag tgccggctca gcatgtgtcc agcgcgcagc 121 ctcctccttg tggctaccct ggtcctcctg gaccacctca gtttggccag aaacctcccc 181 gtggccactc cagacccagg aatgttccca tgccttcacc actcccaaaa cctgctgagg 241 gccgtcagca acatgctcca gaaggccaga caaactctag aattttaccc ttgcacttct 301 gaagagattg atcatgaaga tatcacaaaa gataaaacca gcacagtgga ggcctgttta 361 ccattggaat taaccaagaa tgagagttgc ctaaattcca gagagacctc tttcataact 421 aatgggagtt gcctggcctc cagaaagacc tcttttatga tggccctgtg ccttagtagt 481 atttatgaag acttgaagat gtaccaggtg gagttcaaga ccatgaatgc aaagcttctg 541 atggatccta agaggcagat ctttctagat caaaacatgc tggcagttat tgatgagctg 601 atgcaggccc tgaatttcaa cagtgagact gtgccacaaa aatcctccct tgaagaaccg 661 gatttttata aaactaaaat caagctctgc atacttcttc atgctttcag aattcgggca 721 gtgactattg atagagtgat gagctatctg aatgcttcct aa 1 aagcttcttt tgcataactg gcgctggatt tttactgaga ctttacgtta cagttttttt 61 tttttaaatt tcaaggtgct tttacgaaca catgaataaa atatttgtgt cattttgaac 121 cttacttgtc ttattttatg catgtattta tttatggggg ggcacaagga ctcatctgtg 181 gtggtgcagc cactgtaaat aaattagtga aactacttca cgtcaatttc tgttcagtac 241 actttagtga tggatcggag gaaattaata catgtttaca aaaagcccct cccccagttg 301 ttacatatgc ctcagagata ccagttgtga aaagtgcagg tgcacttaca cacatacgca 361 cacacacccc acaaatggta tcatacgaaa aaacatacct gcaatctgat ttgtccactt 421 aattgtatat cttggataca gaacttgttt cactggaagg ctaaaaggca aagtctgggg 481 aggcctagag gacacagggg atgggaggag gcgctctgag ctggatgtaa ggtctccacc 541 cacggccaga gcacaaggtc ggataaccag tgggcctgCC ggcttggCtg cctgggccct 601 cccctgccga gacaaacggc tggagggagg aagtgtgcgg ctgggaagct ccgctgctct 661 ggcccgggtt tcccatttcc cccttcccgc gctgagacgg cgaggaaagt tagcccggaa 721 atctgcgccc gcctaaaacc cggcctggtc ccagccaccg ccccaggaac ttcccccacc 781 gcaggggcgg aggtcgagag cagggatgga gaagtggacc tgcgcgggtg gactccgggg 841 cgcgggtgga ctccggggcg cggggggact ccgaggagcg ggtggactgt ggggcgcggg 901 taccgtctcg cagcgacctc tgtcggcggc tctggggatg gcccgcatct gtctgcgtgt 961 acctggtata cgtgcaggta catgttcctg ttcacgtgca gactgggcgg gggatggggg 1021 ggtccacacc ggtgtacacc tttgcatacc tcttagcaac ttgaaattcc accacgagag 1081 atatctttat tccgctattc ctgtgcatct gcacggagcc cctagggcca tagatttgtg 1141 tgcaaatgaa atgaggatgt agtctgggtg cccaaggggg ggtgccttga gtgtggttgt 1201 ctgtatgcct ccctgagggt atttcacttt ctgctcccat ccgcccctat gagcgagtac 1261 ctatgagcac aggatgtgca catatttgag tcttattagt ggtacacgca gttttatcat 1321 ctccccaggt ctgtgtctgt atgaaatgtg catgggtgtg tgtgtgcacg cgtgtgttcc 1381 cactcgggga atgtggggag aggtgcatgg agccaagatg ggtggtaaat agtatgtttc 1441 tgaaattaaa ggactaatgt ggaggaaggc gccccagatg tactaaaccc tttgccttca 1501 tctcatcctc tctgacttgg gaagaaccag gattttgttt ttaagccctt gggcatacag 1561 ttgttccatc ccgacatgaa ctcagcccc cgtctgaccg ccccttggcc ttccttcttc 1621 ctcgatctgt ggaacccagg gaatctgcct agtgctgtct ccaagcacct tggccatgat 1681 gtaaacccag agaaattagc atctccatct ccttccttat tccccaccca aaagtcattt 1741 cctcttagtt cattacctgg gattttgatg tctatgttcc ctcctcgtta ttgatacaca 1801 cacagagaga gacaaacaaa aaaggaactt cttgaaattc ccccagaagg ttttgagagt 1861 tgttttcaat gttgcaacaa gtcagtttct agtttaagtt tccatcagaa aggagtagag 1921 tatataagtt ccagtaccag caacagcagc agaagaaaca acatctgttt cagggccatt 1981 ggactctccg tcctgcccag agcaaggtaa gcacttccca agcccctacc tccctcccct 2041 ccctgtgggc ctgcag 1 gaattctcag acagcagcat tagaaggggc cttagagatc aaccatttct cttattttac 61 acacacctaa aactccctac agccgtgctt catcagcttc gagcagatga gccacccaga 121 aggcagctcc agttattagg tcctagggcc tgggtgtagt caggcccttt ggaagctcca 181 agtcagagat caaacacatc ctccccacta cccacgccta gggtgactaa tgcctgtggg 241 aaaaacaact gaactaaaaa gtcccacagg aacctcaaac ccagcacatc caaaatggaa 301 cttctcacca tctcctccaa actcagtcct cttatacagt aatccctgta aagctagaac 361 aatctccatt ccccattctc agggccttcc tctcccgctc acctgaggag ctaccaagcc 421 ttggcccaca agccctctga gagtccctcc tgcccaccct gtgttctcca tactgaataa 481 ggacttggcc acaccttgtc aactcttccc tctgctctac tcctgacccc tggatccccc 541 catcatgcaa attctgccac atctcccgcc taaaacccag gaagactccc cactactctc 601 agcacagaaa gtacactcct tagtatggca tcccctgccc tcatggcatg gcccatccag 661 ccctccagcc tcacaccctg caaggacacc tagaccccca cctccctcaa cccttcatga 721 ctgcgcttct gatccctgtt tcccctggct agaccctgcg tgccctcccg ctggaagcgg 781 tctaatgcct gcttgttttc aacactcagg ctggggcccc tgcctgctcc cgggagcctt 841 tgctgactcc tggaccccgt tgctccggct gagcgtgggc tctttctcta ggtctttcct 901 cccaggactc tgtgtattca tcctatcgtt aaactggatt ctctacaaga gtaataattg 961 cagagtcagc cagctctcat cccttttcag gtttcagaaa agacctgtga acaaaacgcc WO 00/09525 PCT/US99/17712 EPI-109 1245 1021 ttgagtctga tttagtgg caargcccca agggtctt tctccctggg tatcctccac 1081 ctggtgcaac gtcggccz= oatctagtga gccatctaaa ggaacgatga tgagtgaatg 1141 atttgcctac cccttccag: actaggctgg aggtcgtggt tagggcccat ccctacgcag 1201 gacatgcaaa gtgggaggca ctcctctctc tacgtcggca gggggcgctg cacagctgcg 1261 gggcggggta gcttagacac ggggcgtccg gctaaggccg gggacccagg gtggtgggcg 1321 gggtgtcccg cccgcctgt; gaccccgcgc agtaactgcg aacatttcgc tttcattttg 1381 ggccgagctg gaggcggcgg ggccgtcccg gaacggctgc ggccgggcac cccgggagtt 1441 aatccgaaag cgccgcaagc ccccggggcc ggccgcaccg cacgtgtcac cgagaagctg 1501 atgtagagag agacacagaa agagacagaa agcaagagac cagagtccca ggaaagtcct 1561 gccgcgcctc gggacaat:a zaaaaatgtg gccccctggg tcagcctccc agccaccgcc 1621 ctcacctgcc gcggccacag gtctgcatcc agcggctcgc cctgtgtccc tgcagtgccg 1681 gctcagcatg tgtccagcgc gca (2) INFORMATION FOR SEQ ID NO:79: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1742 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:79: 1 caagcccaga gccctgccat ttctgtgggc tcaggtccct actgctcagc cccttcctcc 61 ctcggcaagg ccacaatgaa ccggggagtc ccttttaggc acttgcttct ggtgctgcaa 121 ctggcgctcc tcccagcagc cactcaggga aagaaagtgg tgctgggcaa aaaaggggat 181 acagtggaac tgacctgtac agcttcccag aagaagagca tacaattcca ctggaaaaac 241 tccaaccaga taaagattct aggaaatcag ggctccttct taactaaagg tccatccaag 301 ctgaatgatc gcgctgactc aagaagaagc ctttgggacc aaggaaactt ccccctgac 361 atcaagaatc ttaagataa agactcagat acttacatct gtgaagtgga ggaccagaag 421 gaggaggtgc aattgctagt gttcggattg actgccaact ctgacaccca cctgcttcag 481 gggcagagcc tgaccctgac cttggagagc ccccctggta gtagcccctc agtgcaatgt 541 aggagtccaa ggggtaaaaa catacagggg gggaagaccc tctccgtgtc tcagctggag 601 ctccaggata gtggcaccg gacatgcact gtcttgcaga accagaagaa ggtggagttc 661 aaaatagaca tcgtggtgct agctttccag aaggcctcca gcatagtcta taagaaagag 721 ggggaacagg tggagttctc cttcccactc gcctttacag ttgaaaagct gacgggcagt 781 ggcgagctgt ggtggcaggc ggagagggct tcctcctcca agtcttggat cacctttgac 841 ctgaagaaca aggaagtgtc tgtaaaacgg gttacccagg accctaagct ccagatgggc 901 aagaagctcc cgctccacct caccctgccc caggccttgc ctcagtatgc tggctctgga 961 aacctcaccc tggcccttga agcgaaaaca ggaaagttgc atcaggaagt gaacctggtg 1021 gtgatgagag ccactcagct ccagaaaaat ttgacctgtg aggtgtgggg acccacctcc 1081 cctaagctga tgctgagcct gaaactggag aacaaggagg caaaggtctc gaagcgggag 1141 aaggcggtgt gggtgctgaa ccctgaggcg gggatgtggc agtgtctgct gagtgactcg 1201 ggacaggtcc tgctggaacc caacatcaag gttctgccca catggtccac cccggtgcag 1261 ccaatggccc tgattgtgct ggggggcgtc gccggcctcc tgcttttcat tgggctaggc 1321 atcttcttct gtgtcaggtg ccggcaccga aggcgccaag cagagcggat gtctcagatc 1381 aagagactcc tcagtgagaa gaagacctgc cagtgccctc accggtttca gaagacatgt 1441 agccccattt gaggcacaag gccaggcaga tcccacttgc agcctcccca ggtgtctgcc 1501 ccgcgtttcc tgcctgcgga ccagatgaat gtagcagatc ccacgctctg gcctcctgtt 1561 cgtcctccct acaatttgcc attgtttctc ctgggttagg ccccggcttc actggttgag 1621 tgttgctctc tagtttccag aggcttaatc acaccgtcct ccacgccatt tccttttcct 1681 tcaagcctag cccttctctc attatttctc tctgaccctc tccccactgc tcatttggat 1741 cc (2) INFORMATION FOR SEQ ID NO:80: (i) SEQUENCE CHARACTERISTICS: CA) LENGTH: 237 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear Cxi)SEQUENCE DESCRIPTION: SEQ ID NO:80: ctgccaactc tgacacccac ctgcttcagg ggcagagcct gaccctgacc ttggagagcc 61 cccctggtag tagcccctca gtgcaatgta ggagtccaag gggtaaaaac atacaggggg 121 ggaagaccct ctccgtgtct cagctggagc tccaggatag tggcacctgg acatgcactg 181 ttttgcagaa ccagaagaag gtggagttca aaatagaca cgtggtgcta gctttcc (2) INFORMATION FOR SEQ ID NO:81: Ci) SEQUENCE CHARACTERISTICS: (A) LENGTH: 4040 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single CD) TOPOLOGY: linear Cxi)SEQUENCE DESCRIPTION: SEQ ID NO:81: 1 tgcagagaac agagaaagga catctgcgag gaaagttccc tgatggctgt caacaaagtg 61 ccacgtctct atggctgtgt acgctgagca cacgatttta tcgcgcctat catatcttgg 121 tgcataaacg cacctcacct cggtcaaccc ttgctccgtc ttatgagaca ggctttatta 181 tccgcatttt atatgagggg aatctgacgg tggagagaga attatcttgc tcaaggcgac WO 00/09525 PCT/US99/17712 EPI-109 1246 241 acagcagaac ccacaggtgg cagaatccca cccgagcccg cttzqacczz cggggtggaa 301 accacgggcg cccgcccggc tgcgcttcca gagctgaact gagaagcaag tcctctccac 361 cctgcggcca ccgcccagcc ccgacccccg ccccggcccg atcczcactc gccgccagc: 421 ccccgcgccc accccggagt tggtggcgca gaggcgggag gcggaggcgg gagggcgggc 481 gctggcaccg ggaacgcccg agcgccggca gagagcgcgg agagcgcgac acgtgcggcc 541 cagagcaccg gggccacccg gtccccgcag gcccgggacc gcgcccactg gcaggcgaca 601 cgtggaagaa tacggagttc tataccagag ttgattgttg atggcacata cttttagagg 661 atgctcattg gcacttatgt ttataatcac gtggctgttg attaaagcaa aaatagatac 721 gtgcaagaga ggcgatgtga ctgtgaagcc ttcccatgta atttacttg gatccactgt 781 caatattaca tgctctttga agcccagaca aggctgcttt cac-attcca gacgtaacaa 841 gttaatcctg tacaagtttg acagaagaat caattttcac catagccact ccctcaatc 901 tcaagtcaca ggtcttcccc ttggtacaac cttgtttgtc tgcaaactgg cctgtatcaa 961 tagtgatgaa attcaaatat gtggagcaga gatcttcgtt ggtgttgctc cagaacagcc 1021 tcaaaattta tcctgcatac agaagggaga acaggggact gtggcctgca cctgggaaag 1081 aggacgagac acccacttat acactgagta tactctacag ctaagtggac caaaaaattt 1141 aacctggcag aagcaatgta aagacattta ttgtgactat ttggactztg gaatcaacct 1201 cacccctgaa tcacctgaat ccaatttcac agccaaggtt actgctgtca atagtcttgg 1261 aagctcctct tcacttccat ccacattcac attcttggac atagtgaggc ctcttcctcc 1321 gtgggacatt agaatcaaat ttcaaaaggc ttccgtgagc agatgtaccc tttattggag 1381 agatgaggga ctggtactgc ttaatcgact cagatatcgg cccagtaaca gcaggctctg 1441 gaatatggtt aatgttacaa aggccaaaqg aagacatgat ttgctggatc tgaaaccatt 1501 tacagaatat gaatttcaga tttcctctaa gctacatctt tataagggaa gttggagtga 1561 ttggagtgaa tcattgagag cacaaacacc agaagaagag cctactggga tgttagatgt 1621 ctggtacatg aaacggcaca ttgactacag tagacaacag atttctcttt tctggaagaa 1681 tctgagtgtc tcagaggcaa gaggaaaaat tctccactat caggtgacct tgcaggagct 1741 gacaggaggg aaagccatga cacagaacat cacaggacac acczcctgga ccacagtcat 1801 tcctagaacc ggaaattggg ctgtggctgt gtctgcagca aattcaaaag gcagttctct 1861 gcccactcgt attaacataa tgaacctgtg tgaggcaggg ttgctggctc ctcgccaggt 1921 ctctgcaaac tcagagggca tggacaacat tctggtgact tggcagcctc ccaggaaaga 1981 tccctctgct gttcaggagt acgtggtgga atggagagag ctccatccag ggggtgacac 2041 acaggtccct ctaaactggc tacggagtcg accctacaat gtgtctgctc tgatttcaga 2101 gaacataaaa tcctacatct gttatgaaat ccgtgtgtat gcactctcag gggatcaagg 2161 aggatgcagc tccatcctgg gtaactctaa gcacaaagca ccactgagtg gcccccacat 2221 taatgccatc acagaggaaa aggggagcat tttaatttca tggaacagca ttccagtcca 2281 ggagcaaatg ggctgcctcc tccattatag gatatactgg aaggaacggg actccaactc 2341 ccagcctcag ctctgtgaaa ttccctacag agtctcccaa aattcacatc caataaacag 2401 cctgcagccc cgagtgacat atgtcctgtg gatgacagct ctgacagctg ctggtgaaag 2461 ttcccacgga aatgagaggg aattttgtct gcaaggtaaa gccaattgga tggcgtttgt 2521 ggcaccaagc atttgcattg ctatcatcat ggtgggcatt ttctcaacgc attacttcca 2581 gcaaaaggtg tttgttctcc tagcagccct cagacctcag tggtgtagca gagaaattcc 2641 agatccagca aatagcactt gcgctaagaa atatcccatt gcagaggaga agacacagct 2701 gcccttggac aggctcctga tagactggcc cacgcctgaa gatcctgaac cgctggtcat 2761 cagtgaagtc cttcatcaag tgaccccagt tttcagacat cccccctgct ccaactggcc 2821 acaaagggaa aaaggaatcc aaggtcatca ggcctctgag aaagacatga tgcacagtgc 2881 ctcaagccca ccacctccaa gagctctcca agctgagagc agacaaccgg tggatctgta 2941 caaggtgctg gagagcaggg gctccgaccc aaagccagaa aacccagcct gtccctggac 3001 ggtgctccca gcaggtgacc ttcccaccca tgatggctac ttaccctcca acatagatga 3061 cctcccctca catgaggcac ctctcgctga ctctctggaa gaactggagc ctcagcacat 3121 ctccctttct gttttcccct caagttctct tcacccactc accttctcct gtggtgataa 3181 gctgactctg gatcagttaa agatgaggtg tgactccctc atgctctgag tggtgaggct 3241 tcaagcctta aagtcagtgt gccctcaacc agcacagcct gccccaattc ccccagcccc 3301 tgctccagca gctgtcatct ctgggtgcca ccatcggtct ggctgcagct agaggacagg 3361 caagccagct ctgggggagt cttaggaact gggagttggt cttcactcag atgcctcatc 3421 ttgcctttcc cagggcctta aaattacatc cttcactgtg tggacctaga gactccaact 3481 tgaattccta gtaactttct tggtatgctg gccagaaagg gaaatgagga ggagagtaga 3541 aaccacagct cttagtagta atggcataca gtctagagga ccattcatgc aatgactatt 3601 tctaaagcac ctgctacaca gcaggctgta cacagcagat cagtactgtt caacagaact 3661 tcctgagatg atggaaatgt tctacctctg cactcactgt ccagtacatt agacactagg 3721 cacattggct gttaatcact tggaatgtgt ttagcttgac tgaggaatta aattttgatt 3781 gtaaatttaa atcgccacac atggctagtg gctactgtat tggagtgcac agctctagat 3841 ggctcctaga ttattgagag cctccaaaac aaatcaacct agttctatag atgaagacat 3901 aaaagacact ggtaaacacc aatgtaaaag ggcccccaag gtggtcatga ctggtctcat 3961 ttgcagaagt ctaagaatgt acctttttct ggccgggcgt ggtagctcat gcctgtaatc 402c1 ccagcacttt gggaggctga (2) INFORMATION FOR SEQ ID NO:82: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 6019 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:82: caagcccaga gccctgccat ttctgtgggc tcaggtccct actgctcagc cccttcctcc 61 ctcggcaaag ccacaatgaa ccggggagtc ccctttaggc acttgctct ggtgctgcaa 121 ctggcgctcc tcccagcagc cactcaggga aagaaagtgg tgctgggcaa aaaaggggat WO 00/09525 PCT/US99/17712 EPI-109 1247 181 acagtggaac tgacctgtac agcttcccaa aagaagagca tacaattcca ctggaaaaac 241 tccaaccaga taaagattct gggaaatcag ggctccttct taactaaagg tccatccaag 301 ctgaatgatc gcgctgactc aagaagaagc ctttgggacc aaggaaactt ccccctgatc 361 atcaagaatc ttaaqataga agactcagat acttacatct gtgaagtgga ggaccagaag 421 gaggaggtgc aattgctagt gttcggattg actgccaact ctgacaccca cctgcttcag 481 gggcagagcc tgaccctgac cttggagagc ccccctggta gtagcccctc agtgcaatgt 541 aggagtccaa ggggtaaaaa catacagggg gggaagaccc tctccgtgtc tcagctggag 601 ctccaggata gtggcacctg gacatgcact gtcttgcaga accagaagaa ggtggagttc 661 aaaatagaca tcgtggtgct agctttccag aaggcctcca gcatagtcta taagaaagag 721 ggggaacaug tagagttctc cttcccactc gcctttacag ttgaaaagct gacgggcagt 781 ggcgagctgt ggtggcaggc ggagagggct tcctcctcca agtcttggat cacctttgac 841 ctgaagaaca aggaagtgtc tgtaaaacgg gttacccagg accctaagct ccagatgggc 901 aagaagctcc cgctccacct caccctgccc caggccttgc ctcagtatgc tggctctgga 961 aacctcaccc tggcccttga agcgaaaaca ggaaagttgc atcaggaagt gaacctggtg 1021 gtgatgagag ccactcagct ccagaaaaat ttgacctgtg aggtgtgggg acccacctcc 1081 cctaagctga tgctgagctt gaaactggag aacaaggagg caaaggtctc gaagcgggag 1141 aaggcggtgt gggtgctgaa ccctgaggcg gggatgtggc agtgtctgct gagtgactcg 1201 ggacaggtcc tgctggaatc caacatcaag gttctgccca catggtccac cccggtgcag 1261 ccaatggccc tgattgtgct ggggggcgtc gccggcctcc tgcttttcat tgggctaggc 1321 atcttcttct gtgtcaggtg ccggcaccga aggcgccaag cagagcggat gtctcagatc 1381 aagagactcc tcagtgagaa gaagacctgc cagtgccctc accggtttca gaagacatgt 1441 agccccattt gaggcacgag gccaggcaga tcccacttgc agcctcccca ggtgtctgcc 1501 ccgcgtttcc tgcctgcgga ccagatgaat gtagcagatc ccacgctctg gcctcctgtt 1561 cgtcctccct acaatttgcc attgtttctc ctgggttagg ccccggcttc actggttgag 1621 tgttgctctc tagtttccag aggcttaatc acaccgtcct ccacgccatt tccttttcct 1681 tcaagcctag cccttctctc attatttctc tctgaccctc tccccactgc tcatttggat 1741 cc 1 ctgccaactc tgacacccac ctgcttcagg ggcagagcct gaccctgacc ttggagagcc 61 cccctggtag tagcccctca gtgcaatgta ggagtccaag gggtaaaaac atacaggggg 121 ggaagaccct ctccgtgtct cagctggagc tccaggatag tggcacctgg acatgcactg 181 ttttgcagaa ccagaagaag gtggagttca aaatagacat cgtggtgcta gctttcc 1 tgcagagaac agagaaagga catctgcgag gaaagttccc tgatggctgt caacaaagtg 61 ccacgtctct atggctgtgt acgctgagca cacgatttta tcgcgcctat catatcttgg 121 tgcataaacg cacctcacct cggtcaaccc ttgctccgtc ttatgagaca ggctttatta 181 tccgcatttt atatgagggg aatctgacgg tggagagaga attatcttgc tcaaggcgac 241 acagcagagc ccacaggtgg cagaatccca cccgagcccg cttcgacccg cggggtggaa 301 accacgggcg cccgcccggc tgcgcttcca gagctgaact gagaagcgag tcctctccgc 361 cctgcggcca ccgcccagcc ccgacccccg ccccggcccg atcctcactc gccgccagct 421 ccccgcgccc accccggagt tggtggcgca gaggcgggag gcggaggcgg gagggcgggc 481 gctggcaccg ggaacgcccg agcgccggca gagagcgcgg agagcgcgac acgtgcggcc 541 cagagcaccg gggccacccg gtccccgcag gcccgggacc gcgcccgctg gcaggcgaca 601 cgtggaagaa tacggagttc tataccagag ttgattgttg atggcacata cttttagagg 661 atgctcattg gcatttatgt ttataatcac gtggctgttg attaaagcaa aaatagatgc 721 gtgcaagaga ggcgatgtga ctgtgaagcc ttcccatgta attttacttg gatccactgt 781 caatattaca tgctctttga agcccagaca aggctgcttt cactattcca gacgtaacaa 841 gttaatcctg tacaagtttg acagaagaat caattttcac catggccact ccctcaattc 901 tcaagtcaca ggtcttcccc ttggtacaac cttgtttgtc tgcaaactgg cctgtatcaa 961 tagtgatgaa attcaaatat gtggagcaga gatcttcgtt ggtgttgctc cagaacagcc 1021 tcaaaattta tcctgcatac agaagggaga acaggggact gtggcctgca cctgggaaag 1081 aggacgagac acccacttat acactgagta tactctacag ctaagtggac caaaaaattt 1141 aacctggcag aagcaatgta aagacattta ttgtgactat ttggactttg gaatcaacct 1201 cacccctgaa tcacctgaat ccaatttcac agccaaggtt actgctgtca atagtcttgg 1261 aagctcctct tcacttccat ccacattcac attcttggac atagtgaggc ctcttcctcc 1321 gtgggacatt agaatcaaat ttcaaaaggc ttccgtgagc agatgtaccc tttattggag 1381 agatgaggga ctggtactgc ttaatcgact cagatatcgg cccagtaaca gcaggctctg 1441 gaatatggtt aatgttacaa aggccaaagg aagacatgat ttgctggatc tgaaaccatt 1501 tacagaatat gaatttcaga tttcctctaa gctacatctt tataagggaa gttggagtga 1561 ttggagtgaa tcattgagag cacaaacacc agaagaagag cctactggga tgttagatgt 1621 ctggtacatg aaacggcaca ttgactacag tagacaacag atttctcttt tctggaagaa 1681 tctgagtgtc tcagaggcaa gaggaaaaat tctccactat caggtgacct tgcaggagct 1741 gacaggaggg aaagccatga cacagaacat cacaggacac acctcctgga ccacagtcat 1801 tcctagaacc ggaaattggg ctgtggctgt gtctgcagca aattcaaaag gcagttctct 1861 gcccactcgt attaacataa tgaacctgtg tgaggcaggg ttgctggctc ctcgccaggt 1921 ctctgcaaac tcagagggca tggacaacat tctggtgact tggcagcctc ccaggaaaga 1981 tccctctgct gttcaggagt acgtggtgga atggagagag ctccatccag ggggtgacac 2041 acaggtccct ctaaactggc tacggagtcg accctacaat gtgtCtgctc tgatttcaga 2101 gaacataaaa tcctacatct gttatgaaat ccgtgtgtat gcactctcag gggatcaagg 2161 aggatgcagc tccatcctgg gtaactctaa gcacaaagca ccactgagtg gcccccacat 2221 taatgccatc acagaggaaa aggggagcat tttaatttca tggaacagca ttccagtcca 2281 ggagcaaatg ggctgcctcc tccattatag gatatactgg aaggaacggg actccaactc 2341 ccagcctcag ctctgtgaaa ttccctacag agtctcccaa aattcacatc caataaacag 2401 cctgcagccc cgagtgacat atgtcctgtg gatgacagct ctgacagctg ctggtgaaag 2461 ttcccacgga aatgagaggg aattttgtct gcaaggtaaa gccaattgga tggcgtttgt 2521 ggcaccaagc atttgcattg ctatcatcat ggtgggcatt ttctcaacgc attacticca 2581 gcaaaaggtg tttgttctcc tagcagccct cagacctcag tggtgtagca gagaaattcc WO 00/09525 PCTIUS99/17712 EPI-109 1248 2641 agatccagca aatagcact gcgctaaaaa atatcccatt gcagaggaga agacacagct 2701 gcccttggac aggctcctza tagactggcc cacgcctgaa gatcctgaac cgctggtcat 2761 cagtgaagtc cttcatcaag tgaccccagt uttcagacat cccccctgct ccaactggcc 2821 acaaagggaa aaaggaatcc aaggtcatca ggcctctgag aaagacatga tgcacagtgc 2881 ctcaagccca ccacctccaa gagctctcca agctgagagc agacaactgg tggatctgta 2941 caaggtgctg gagagcaggg gctccgaccc aaagccagaa aacccagcct gtccctggac 3001 ggtgctccca gcaggtgacc ttcccaccca tgatggctac ttaccctcca acatagatga 3061 cctcccctca catgaggcac ctctcgctga ctctctggaa gaactggagc ctcagcacat 3121 ctccctttct gttttcccct caagttctct tcacccactc accttctcct gtggtgataa 3181 gctgactctg gatcagttaa agatgaggtg tgactccctc atgctctgag tggtgaggct 3241 tcaagcctta aagtcaatgt gccctcaacc agcacagcct gccccaattc ccccagcccc 3301 tgctccagca gctgtcatct ctgggtgcca ccatcggtct ggctgcagct agaggacagg 3361 caagccagct ctgggggaat cttaggaact gggagttggt cttcactcag atgcctcatc 3421 ttgcctttcc cagggcctta aaattacatc cttcactgtg tggacctaga gactccaact 3481 tgaattccta gtaactttct tggtatgctg gccagaaagg gaaatgagga ggagagtaga 3541 aaccacagct cttagtagta atggcataca gtctagagga ccattcatgc aatgactatt 3601 tctaaagcac ctgctacaca gcaggctgta cacagcagat cagtactgtt caacagaact 3661 tcctgagatg atggaaatgt tctacctctg cactcactgt ccagtacatt agacactagg 3721 cacattggct gttaatcact tggaatgtgt ttagcttgac tgaggaatta aattttgatt 3781 gtaaatttaa atcgccacac atggctagtg gctactgtat tggagtgcac agctctagat 3841 ggctcctaga ttattgagag cctccaaaac aaatcaacct agttctatag atgaagacat 3901 aaaagacact ggtaaacacc aatgtaaaag ggcccccaag gtggtcatga ctggtctcat 3961 ttgcagaagt ctaagaatgt acctttttct ggccgggcgt ggtagctcat gcctgtaatc 4021 ccagcacttt gggaggctga (2) INFORMATION FOP. SEQ ID NO: 83: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 5670 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:83: 1 ggatccccgc tgacaatcta gaaacaagca acagaccctc tgatgtagcc atctgtgccg 61 cgcctctccg caccgcccgc cacgccttgg tccctggaga ccaccctcca gggcaggggc 121 tgccgctcgg ccgggcccgc ggggtccctc ggcctgacat ggccggtgct ggagcggcac 181 gtgcgcgcct cggcccctcg gccgctcccg cccctcgccg gtgcgcaccg gcgctcgggg 241 agccgctggc ccgggtgtcc agccggccct tgccctgcct ggcgctcgga ccgccacctt 301 tgccgccccc tcgccagcct ccgcagcttc cagactggcc ggtctgcgcg cccacccctg 361 cctcccggac cggccaccgc cggaggccgc ggaggagggc ccggccgcgc agatcccgct 421 tatcgggccc catctcccgt tacataaggc caccccccta tctccgcggg ccatcgccgc 481 cgcaaccgcc gcgccagcgc cttctcccac gcgcgggggc gcccctgccc accgctcccg 541 gcagggcttt tggtggccat gggggataag gggcgttgac tcacccgggc ggggctccgg 601 gagttgcaca gaccaaggta gttccccgct ccttccccca tcacggagac cctgtgggag 661 atgccgtggg ccctctacta cagattagga aacaggcccg tagaggggtc gcgcggccaa 721 gtagcggcac tccaggcact gggggccctc gagggaaggg gcagacttct gggagtcaga 781 gccagcagct gggctgggaa gcttcgagtg tggacagaga gggtgggaat gacgttccct 841 gtgggaagag agggtgggca agcctgggat gcctctgagc gggaatccag catgccttgt 901 gaggagggtc acaagcacac ccttgtgagg aggttgagcc ccatcgagga caggacggag 961 ggagcctgag caggcagaga gggggcctgg ggaggcgctg gttcggggag gaagtgggta 1021 ggggagaaat cttgacatca acacccaaca ggcaaatgcc gtggcctctg ctgtgggggt 1081 ttctggagga cttctaggaa aacgagggaa gagcaggaaa aggcgacatg gctgtagggc 1141 caagcccagg agccgccctc cacagcactc attctgcaga agggaaattt gaggccccca 1201 gacggcaggg gttgatcctg cagagactgg tgagcaaagg ggatcacccc aagccccagt 1261 ggcactagga acacttacaa tctctgacct ggactaaggc tgccagcctg gcccagttaa 1321 gagtttccca gaaggatggc ccatacactt taaattaaag gggccagaca cgtgcacact 1381 acttccagcc actctggaag ctgaggtggg gggatcgctt gagtctggga gttggaggcc 1441 agcctaggca ggcaacatag tgagacccca tctccaaaaa aacaaaacaa aacaaaacaa 1501 aaaaacacca aaaaagctcc cagaaagacc tctgaatctt tctggatctc tcagtggaga 1561 cctggaaatc tgaactttga caatccctct cacagtgggg ccaaggagga attaggcaag 1621 ccaaaagaag tgaactttac tcttctattg cctgtttgaa ttttgtatcc aagcaagtgt 1681 tacttaagta atttaagaga ctggttcatc gaaaaaataa aactccccaa attcccatag 1741 ctggtagact gtggtcacag ccacagtgca ctaagactat ctgctcagca cttctggtga 1801 cccaaaaggg tctgaggaca ggagctcaga gttgggtcag ctgtccaggt actcagggtt 1861 gtcacaggca aaactgctgg aactcagggc agcattgcaa atgccacgcc gctctcaggg 1921 ccccttgcct gccgctggaa ttaaacccac ccagatcttg gaaactctgc cctggaccct 1981 tctcaataag tccatgagaa atcaaactct ttcctttatg cgacactgga ttttccacaa 2041 agtaaaatca agatgegtaa agatgtggtt tctagatagt gcctgaaaaa gcagagacca 2101 tggtgtcagg cgtcaccact tgggcctata aaagctgcca caagacgcca aggccacaag 2161 ccacccagcc tatgcatccg ctcctcaatc ctctcctgtt ggcactgggc ctcatggcgc 2221 ttttgttgac cacggtcatt gctctcactt gccttggcgg ctttgcctcc ccaggccctg 2281 tgcctccctc tacagccctc agggagctca ttgaggagct ggtcaacatc acccagaacc 2341 agaaggtgag tgtcggctag ccagggtcct agctatgagg gctccagggt gggtgattcc 2401 caagatgagg acatgagcag gctgggcctg gtcctaagat gcctgtaggt caggaaaaat 2461 ctccatggac caaggcccgg cccagccatg agggagagag gagctgggct ggggggctca 2521 gcactgtgga cggacctatg gaggtgtctg gcagactccc cagggactac ctgctctcct WO 00/09525 PCT/US99/17712 EPI-109 1249 2581 ggcctgacet tgtctgczaz tqccagctcc tactcaacca ttgaaca gaggacagca 2641 gagaagggcc agcaccczcc cagaaccatg tggcaztgc caaczggatt ttgaccaraa 2701 caatgcagcc attctccca acaccatcat aggcccaccc ttacaggagg attCgttagt 2761 agagtccgct ccttgcccca ctagtaacag ctcacatgtc tgagcactgc ttacaccagg 2821 cctggtgcac gtgctttatc tgtcatttca tcactaccag ccacctcaag aggcaggtac 2881 gatgaaccca ttctgctaag gttcagtgag gttaagtgac agaggctgga ttcaagccag 2941 gcctggccaa caccagag:a tccatgctcc taactacagt gttccctcac catcagaagg 3001 cagggcattt aatacaccag atccccaccq cctcccatct gatttgtctt ggtcaacagt 3061 ggcccaggcc actcctac: cactcgtccc caccctggcc cttcccgcag gcccctgtcc 3121 tcctgccctg actatggcaa gccttgcatg cagCttatCc ctzactagtg gtgtcaattt 3181 ttttctctca gctccaaaac cctaaacagt gggacctcaC ccctatgcct gctgttcaaa 3241 gcagaaaacg aagctcaaa atgctgaggg gctgccaggc ctacctctgt gccacaccag 3301 ggatgcttgt ggggcct::a ctggggcaga cctggcctgg gctgccaggg caggcccaca 3361 acccctgcca gcactczact cactgtcact ttgctcccac aggctccgct ctgcaatggc 3421 agcatggtat ggagcatcaa cctgacagct ggcatautaa ggacctttgg gtgcagggag 3481 gatggggcag aggctccaag ccttgggctt atcttctctg agcctccctt ccatggctgg 3541 ggttccaagc aagcttcaag tgctctcctc cctcccgcca taatctggcc ccttcccgcc 3601 caccacccag actcacczc gccaggcatc tcagccccat cttcctgcag actcacaaaa 3661 ggcagctgcc caagcagggc ctgacccctc ggtgtcccct ccccacagta ctgtgcagcc 3721 ctggaatccc tgatcaacat gtcaggctgc agtgccatcg agaagaccca gaggatgctg 3781 agcggattct gcccgcacaa ggtctcagct ggggtaaggc atcccccacc ctctcacacc 3841 caccctgcac cccctcctgc caaccctggg ctcgctgaag ggaagctggc tgaatatcca 3901 tggtgtgtgt ccacccaggg gtggggccat tgtggcagca gggacgtggc cttcgggatt 3961 tacaggatct gggctcaagg gctcctaact cctacctggg cctcaatttc cacatctgta 4021 cagtagaggt actaacagta cccacctcat ggggacttcc gtgaggactg aatgaqacag 4081 tccctggaaa gcccctgrt tgtgcgagtc gtcccagcct ctggcgttct actcacgtgc 4141 tgacctcttt gtcctgcaac agttttccag cttgcatgtc cgagacacca aaatcgaggt 4201 ggcccagttt gtaaaggacc tgctcttaca tttaaagaaa ctttttcgcg agggacggtt 4261 caactgaaac ttcgaaaaca tcattatttg cagagacagg acctgactat tgaagttgca 4321 gattcatttt tctttctgac gtcaaaaatg tcttgggtag gcgggaagga gggttaggga 4381 ggggtaaaat tccttagczt agacctcagc ctgtgctgcc cgtcttcagc ctagccgacc 4441 tcagccttcc ccttgcccag ggctcagcct ggtgggcctc ctctgtccag ggccctgagc 4501 tcggtggacc cagggatgac atgtccctac acccctcccc tgccctagag cacactgtag 4561 cattacagtg ggtgcccccc itgccagaca tgtggtggga cagggaccca cttcacacac 4621 aggcaactga ggcagacagc agctcaggca cacttcttct tggtcttatt tattattgtg 4681 tgttatttaa atgagtgtgt ttgtcaccgt tggggattgg ggaagactgt ggctgctggc 4741 acttggagcc aagggttcag agactcaggg ccccagcact aaagcagtgg accccaggag 4801 tccctggtaa taagtactgt gtacagaatt ctgctacctc actggggtcc tggggcctcg 4861 gagcctcatc cgaggcaggg tcaggagagg ggcagaacag ccgctcctgt ctgccagcca 4921 gcagccagct ctcagccaac gagtaattta ttgtttttcc tcgtatttaa atattaaata 4981 tgttagcaaa gagttaatat atagaagggt accttgaaca ctgggggagg ggacattgaa 5041 caagttgttt cattgactat caaactgaag ccagaaataa agttggtgac agataggcct 5101 gattgtattt gtctttcatt ttggcctttg gggacactgg tctgtggtct gaagactctg 5161 aggagctctt cgggaggctg gtgggttgga ggaggggact gggatggatt acagcgaggg 5221 tagggtgcag tgacctgagc tgaatgcaag ctagctcccg agggtgggga catggcctga 5281 aggaagcccc accttctgtc tgctgcacca gcaaggacgg agaggcttgg gccagactgt 5341 cagggttcaa ggagggcatc aggagcagac ggagacccaq gaagtctcac aatcacatct 5401 cctgaggact ggccagctgt gtctggcacc acccacacat ccatgtctcc ctcacaaccc 5461 aggaggccga tgagaactat gaggctcaga aagcgtgggc ggtttgccta aggtcacgta 5521 gctacttcct cactggggtc ctggggcctc agagcctcat ctgaggtaaa ggagcaaagt 5581 tgggattggg gtccaaaatt cactttaact ccaaagccca cacacttaac caccctgcct 5641 atttctgtcc aaatgtcacc tgtcctgaat (2) INFORMATION FOR SEQ ID NO:84: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1282 base pairs (B) TYPE: nucleic acid (C) STRAI4DEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:84: aagccaccca gcctatgcat ccgctcctca atcctctcct gttggcactg ggcctcatgg 61 cgcttttgtt gaccacggtc attgctctca cttgccttgg cggctttgcc tccccaggcc 121 ctgtgcctcc ctctacagcc ctcagggagc tcattgagga gctggtcaac atcacccaga 181 accagaaggc tccgctctgc aatggcagca tggtatggag catcaacctg acagctggca 241 tgtactgtgc agccctggaa tccctgatca acgtgtcagg ctgcagtgcc atcgagaaga 301 cccagaggat gctgagcgga ttctgcccgc acaaggtctc agctgggcag ttttccagct 361 tgcatgtccg agacaccaaa atcgaggtgg cccagtttgt aaaggacctg ctcttacatt 421 taaagaaact ttttcgcgag ggacggttca actgaaactt cgaaagcatc attatttgca 481 gagacaggac ctgactattg aagttgcaga ttcatttttc tttctgatgt caaaaatgtc 541 ttgggtaggc gggaaggagg gttagggagg ggtaaaattc cttagcttag acctcagcct 601 gtgctgcccg tcttcagccc agccgacctc agccttcccc ttgcccaggg ctcagcctgg 661 tgggcctcct ctgtccagg ccctgagctc ggtggaccca gggatgacat gtccctacac 721 ccctcccctg ccctagagca cactgtagca ttacagtggg tgcccccctt gccagacatg 781 tggtgggaca gggacccat tcacacacag gcaactgagg cagacagcag ctcaggcaca 841 cttcttcttg gtcttattta ttattgtgtg ttatttaaat gagtgtgttt gtcaccgttg WO 00/09525 PCT/US99/17712 EPI-109 1250 901 gggattgggg aaaactggg ctgctggcac ttggagccaa gggttcaaa actcagggcc 961 ccagcactaa agcagtggac cccaggagtc cctggtaata agtactgt acagaattct 1021 gctacctcac tggggtcctg gggcctcgga gcctcatccg aggcaggatc aggagagggg 1081 cagaacagcc gctcctgtct gccagccagc agccagctct cagccaacga gtaatttatt 1141 gtttttcctc gtatttaaat attaaatatg ttagcaaaga gttaatatat agaagggtac 1201 cttgaacact gggggagggg acattgaaca agttgtttca ttgactazca aactgaagcc 1261 agaaataaag ttggtgacag at (2) INFORMATION FOR SEQ ID NO:85: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 6952 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:85: 1 ggatccccgc tgacaatcta gaaacaagca acagaccctc tgatgtagcc atctgtgccg 61 cgcctctccg caccgcccgc cacgccttgg tccctggaga ccaccctcca gggcaggggc 121 tgccgctcgg ccgggcccgc ggggtccctc ggcctgacat ggccggtgct ggagcggcac 181 gtgcgcgcct cggcccctcg gccgctcccg cccctcgccg gtgcgcaccg gcgctcgggg 241 agccgctggc ccgggtgtcc agccggccct tgccctgcct ggcgctcgga ccgccacctt 301 tgccgccccc tcgccagcct ccgcagcttc cagactggcc ggtctgcgcg cccacccctg 361 cctcccggac cggccaccgc cggaggccgc ggaggagggc ccggccgcgc agatcccgct 421 tatcgggccc catctcccgt tacataaggc caccccccta tctccgcggg ccatcgccgc 481 cgcaaccgcc gcgccagcgc cttctcccac gcgcgggggc gcccctgccc accgctcccg 541 gcagggcttt tggtggccat gggggataag gggcgttgac tcacccgggc ggggctccgg 601 gagttgcaca gaccaaggta gttccccgct ccttccccca tcacggagac cctgtgggag 661 atgccgtggg ccctctacta caqattagga aacaggcccg tagaggggtc gcgcggccaa 721 gtagcggcac tccaggcact gggggccctc gagggaaggg gcagacttct gggagtcaga 781 gccagcagct gggctgggaa gcttcgagtg tggacagaga gggtgggaat gacgttccct 841 gtgggaagag agggtgggca agcctgggat gcctctgagc gggaatccag catgccttgt 901 gaggagggtc acaagcacac ccttgtgagg aggttgagcc ccatcgagga caggacggag 961 ggagcctgag caggcagaga gggggcctgg ggaggcgctg gttcggggag gaagtgggta 1021 ggggagaaat cttgacatca acacccaaca ggcaaatgcc gtggcctctg ctgtgggggt 1081 ttctggagga cttctaggaa aacgagggaa gagcaggaaa aggcgacatg gctgtagggc 1141 caagcccagg agccgccctc cacagcactc attctgcaga agggaaattt gaggccccca 1201 gacggcaggg gttgatcctg cagagactgg tgagcaaagg ggatcacccc aagccccagt 1261 ggcactagga acacttacaa tctctgacct ggactaaggc tgccagcctg gcccagttaa 1321 gagtttccca gaaggatggc ccatacactt taaattaaag gggccagaca cgtgcacact 1381 acttccagcc actctggaag ctgaggtggg gggatcgctt gagtctggga gttggaggcc 1441 agcctaggca ggcaacatag tgagacccca tctccaaaaa aacaaaacaa aacaaaacaa 1501 aaaaacacca aaaaagctcc cagaaagacc tctgaatctt tctggatctc tcagtggaga 1561 cctggaaatc tgaactttga caatccctct cacagtgggg ccaaggagga attaggcaag 1621 ccaaaagaag tgaactttac tcttctattg cctgtttgaa ttttgtatcc aagcaagtgt 1681 tacttaagta atttaagaga ctggttcatc gaaaaaataa aactccccaa attcccatag 1741 ctggtagact gtggtcacag ccacagtgca ccaagactat ctgctcagca cttctggtga 1801 cccaaaaggg tctgaggaca ggagctcaga gttgggtcag ctgtccaggt actcagggtt 1861 gtcacaggca aaactgctgg aactcagggc agcattgcaa atgccacgcc gctctcaggg 1921 ccccttgcct gccgctggaa ttaaacccac ccagatcttg gaaactctgc cctggaccct 1981 tctcaataag tccatgagaa atcaaactct ttcctttatg cgacactgga ttttccacaa 2041 agtaaaatca agatgagtaa agatgtggtt tctagatagt gcctgaaaaa gcagagacca 2101 tggtgtcagg cgtcaccact tgggcctata aaagctgcca caagacgcca aggccacaag 2161 ccacccagcc tatgcatccg ctcctcaatc ctctcctgtt ggcactgggc ctcatggcgc 2221 ttttgttgac cacggtcatt gcactcactt gccttggcgg ctttgcctcc ccaggccctg 2281 tgcctccctc tacagccctc agggagctca ttgaggagct ggtcaacatc acccagaacc 2341 agaaggtgag tgtcggctag ccagggtcct agctatgagg gctccagggt gggtgattcc 2401 caagatgagg tcatgagcag gctgggcctg gtcctaagat gcctgtaggt caggaaaaat 2461 ctccatggac caaggcccgg cccagccatg agggagagag gagctgggct ggggggctca 2521 gcactgtgga tggacctatg gaggtgtctg gcagactccc cagggactac ctgctctcct 2581 ggcctggcct tgtctgccac tgccagctcc tactcagcca ttcctgaaca gaggacagca 2641 gagaagggcc agcaccctcc cagaaccatg tggcatttgc caactggatt ttgaccataa 2701 caatgcagcc attctcccca gcaccatcat aggcccgccc ttacaggagg attcgttagt 2761 agagtccgct ccttgcccca ctagtaacag ctcacatgtc tgagcactgc ttacaccagg 2821 ccgggtgcac gtgctttatg tgtcatttca tcactgccag ccacctcaag aggcaggtac 2881 gatgaaccca ttctgctaag gttcagtgag gttaagtgac agaggctgga ttcaagccag 2941 gcctggccaa caccagagtg tccatgctcc taactgcagt gttccctcac catcagaagg 3001 cagggcattt aatacaccag atccccaccg cctcccatct gatttgtctt ggtcaacagt 3061 ggcccaggcc actcctactt cactcgtccc caccctggcc cttcccgcag gcccctgtcc 3121 tcctgccctg actatggcaa gccttgcatg cagcttgtcc cttactagtg gtgtcaattt 3181 ttttctctca gctccaagac cctaaacagt gggacctcac ccctatgcct gctgttcaaa 3241 gcagaaaacg aagctcagga atgctgaggg gctgccaggc ctgcctcgt gccacaccag 3301 ggatgcttgt ggggcctgtg ctggggcaga cctggcctgg gctgccaggg caggcccaca 3361 acccctgcca gcactctgct cactgtcact ttgctcccac aggctccgct ctgcaatggc 3421 agcatggtac ggagcatcaa cctgacagct ggcatggtaa ggacctttgg gtgcagggag 3481 gatggggcag aggctccagg ccttgggctt atcttctctg agcctccctt ccatggctgg 3541 ggttccaagc aagcttcaag tgctctcctc cctcccgcca taatctggcc ccttcccgcc WO 00/09525 PCT/US99/17712 EPI-109 1251 3601 caccacccaa actcacctgc accaggcatc tcagccccat cttcctgcag actcacaaaa 3661 ggcagctgcc caagcagggc ctgacccctc ggtgtcccct ccccacagta ctgtgcagcc 3721 ctggaatccc tgatcaacgt gtcaggctgc agtgccatcg agaagaccca gaggatgctg 3781 agcggattct gcccgcacaa ggtctcagct ggggtaaggc atcccccacc ctctcacacc 3841 caccctgcac cccctcctgc caaccctggg ctcgctgaag ggaagctggC tgaatatcca 3901 tggtgtgtgt ccacccaggg gtggggccat tgtggcagca gggacgtggc cttcgggatt 3961 tacaggatcc gggctcaagg gctcctaact cctacctggg cctcaatttc cacatctgta 4021 cagtagaggt actaacagca cccacctcat ggggacttcc gtgaggactg aatgagacag 4081 tccctggaaa gcccctggtt tgtgcgagtc gtcccggcct ctggcgttct actcacgtgc 4141 tgacctcttt gtcctgcagc agttttccag cttgcatgtc cgagacacca aaatcgaggt 4201 ggcccagttt gtaaaqgacc tgctcttaca tttaaagaaa ctttttcgcg agggacggtt 4261 caactgaaac ttcgaaagca tcattatttg cagagacagg acctgactat tgaagttgca 4321 gattcatttt tctttctgat gtcaaaaatg tcttgggtag gcgggaagga gggttaggga 4381 ggggtaaaat tccttagctt agacctcagc ctgtgctgcc cgtcttcagc ctagccgacc 4441 tcagccttcc ccttgcccag ggctcagcct ggtgggcctc ctctgtccag ggccctgagc 4501 tcggtggacc cagggatgac atgtccctac acccctcccc tgccctagag cacactgtag 4561 cattacagtg ggtgcccccc ttgccagaca tgtggtggga cagggaccca cttcacacac 4621 aggcaactga ggcagacagc agctcaggca cacttcttct tggtcttatt tattattgtg 4681 tgttatttaa atgagtgtgt ttgtcaccgt tggggattgg ggaagactgt ggctgctggc 4741 acttggagcc aagggttcag agactcaggg ccccagcact aaagcagtgg accccaggag 4801 tccctggtaa taagtactgt gtacagaatt ctgctacctc actggggtcc tggggcctcg 4861 gagcctcatc cgaggcaggg tcaggagagg ggcagaacag ccgctcctgt ctgccagcca 4921 gcagccaqct ctcagccaac gagtaattta ttgtttttcc tcgtatttaa atattaaata 4981 tgttagcaaa gagttaatat atagaagggt accttgaaca ctgggggagg ggacattgaa 5041 caagttgttt cattgactat caaactgaag ccagaaataa agttggtgac agataggcct 5101 gattgtattt gtctttcatt ttggcctttg gggacactgg tctgtggtct gaagactctg 5161 aggagctctt cgggaggctg gtgggttgga ggaggggact gggatggatt acagcgaggg 5221 tagggtgcag tgacctgggc tgaatgcaag ctagctcccg agggtgggga catggcctga 5281 aggaagcccc accttctgtc tgctgcacca gcaaggacgg agaggcttgg gccagactgt 5341 cagggttcaa ggagggcatc aggagcagac ggagacccag gaagtctcac aatcacatct 5401 cctgaggact ggccagctgt gtctggcacc acccacacat ccatgtctcc ctcacaaccc 5461 aggaggccga tgagaactgt gaggctcaga aagcgtgggc ggtttgccta aggtcacgta 5521 gctacttcct cactggggtc ctggggcctc agagcctcat ctgaggtaaa ggagcaaagt 5581 tgggattggg gtccaaaatt cactttaact ccaaagccca cacacttaac caccctgcct 5641 atttctgtcc aaatgtcacc tgtcctgaat aagccaccca gcctatgcat ccgctcctca atcctctcct gttggcactg ggcctcatgg 61 cgcttttgtt gaccacggtc attgctctca cttgccttgg cggctttgcc tccccaggcc 121 ctgtgcctcc ctctacagcc ctcagggagc tcattgagga gctggtcaacatcacccaga 181 accagaaggc tccgctctgc aatggcagca tggtatggag catcaacctg acagctggca 241 tgtactgtgc agccctggaa tccctgatca acgtgtcagg ctgcagtgcc atcgagaaga 301 ccagaggat gctgagcgga ttctgcccgc acaaggtctC agctgggcag ttttccagct 361 tgcatgtccg agacaccaaa atcgaggtgg cccagtttgt aaaggacctg ctcttacatt 421 taaagaaact ttttcgcgag ggacggttca actgaaactt cgaaagcatc attatttgca 481 gagacaggac ctgactattg aagttgcaga ttcatttttc tttctgatgt caaaaatgtc 541 ttgggtaggc gggaaggagg gttagggagg ggtaaaattc cttagcttag acctcagcct 601 gtgctgcccg tcttcagcct agccgacctc agccttcccc ttgcccaggg ctcagcctgg 661 tgggcctcct ctgtccaggg ccctgagctc ggtggacCca gggatgacat gtccctacac 721 cccccccg ccctagagca cactgtagca ttacagtggg tgcccccctt gccagacatg 781 tggtgggaca gggacccact tcacacacag gcaactgagg cagacagcag ctcaggcaca 841 cttcttcttg gtcttattta ttattgtgtg ttatttaaat gagtgtgttt gtcaccgttg 901 gggattgggg aagactgtgg ctgctggcac ttggagccaa gggttcagag actcagggcc 961 ccagcactaa agcagtggac cccaggagtc cctggtaata agtactgtgt acagaattct 1021 gctacctcac tggggtcctg gggcctcgga gcctcatccg aggcagggtc aggagagggg 1081 cagaacagcc gctcctgtct gccagccagc agccagctct cagccaacga gtaatttatt 1141 gtttttcctc gtatttaaat attaaatatg ttagcaaaga gttaatatat agaagggtac 1201 cttgaacact gggggagggg acattgaaca agttgtttca ttgactatca aactgaagcc 1261 agaaataaag ttggtgacag at (2) INFORMATION FOPR SEQ ID NO:86: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1270 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single D)TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:86: 1 ttcggcatcc gctcctcaat cctctcctgt tggcactggg cctcatggcg cttttgttga 61 ccacggtcat tgctctcact tgccttggcg gctttgcctc cccaggccct gtgcctccct 121 ctacagccct cagggagctc attgaggagc tggtcaacat cacccagaac cagaaggctc 181 cgctctgcaa tggcagcatg gtatggagca tcaacctgac agctggcatg tactgtgcag 241 ccctggaatc cctgatcaac gtgtcaggct gcagtgccat cgagaagacc cagaggatgc 301 tgagcggatt ctgcccgcac aaggtctcag ctgggcagtt ttccagcttg catgtccgag 361 acaccaaaat cgaggtggcc cagtttgtaa aggacctgct cttacattta aagaaacttt 421 ttcgcgaggg acggttcaac tgaaacttcg aaagcatcat tatttgcaga gacaggacct 481 gactattgaa gttgcagatt catttttctt tctgatgtca aaaatgtctt gggtaggcgg 541 gaaggagggt tagggagggg taaaattcct tagcttagac ctcagcctgt gctgcccgtc WO 00/09525 PCT/US99/17712 EPI-109 1252 601 ttcagcctag ccgacctcag ccttcccctt zgcccagggcz cagcctggtg ggcctcctct 661 gtccagggcc ctgagctcgg tggacccagg gazgacatat ccctacaccc ctcccctgcc 721 ctagagcaca ctgtagcatu acagtgggtg cccccttgc cagacatgtg gtgggacagg 781 gacccacttc acacacaggc aactgaggca aacagcagct caggcacact tcttcttggt 841 cttatttatt attgtgtgtt atttaaatga gtgtgtttgt caccgttggg gattggggaa 901 gactgtggct gctggcactt ggagccaagg gttcagagac tcagggcccc agcactaaag 961 cagtggaccc caggagtccc tggtaataag tactgtgtac agaattctgc tacctcactg 1021 gggtcctggg gcctcggagc ctcatccgag gcagggtcag gagaggggca gaacagccgc 1081 tcctgtctgc cagccagcag ccagctctca gccaacgagt aatttattgt ttttcctcgt 1141 atttaaatat taaatatgtt agcaaagagt taatatatag aagggtacct tgaacactgg 1201 gggaggggac attgaacaag ttgtttcatt gactatcaaa ctgaagccag aaataaagtt 1261 ggtgacagat (2) INFORMATION FOR SEQ ID NO:87: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 3999 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:87: 1 tcagcccggc cgggctccga ggcgagaggc tgcatggagt ggccggcgcg gctctgcggg 61 ctgtgggcgc tgctgctctg cgccggcggc gggggcgggg gcgggggcgc cgcgcctacg 121 gaaactcagc cacctgtgac aaatttgagt gtctctgttg aaaacctctg cacagtaata 181 tggacatgga atccacccga gggagccagc tcaaattgta gtctatggta ttttagtcat 241 tttggcgaca aacaagataa gaaaatagct ccggaaactc gtcgttcaat agaagtaccc 301 ctgaatgaga ggatttgtct gcaagtgggg tcccagtgta gcaccaatga gagtgagaag 361 cctagcattt tggttgaaaa atgcatctca cccccagaag gtgatcctga gtctgctgtg 421 actgagcttc aatgcatttg gcacaacctg agctacatga agtgttcttg gctccctgga 481 aggaatacca gtcccgacac taactatact ctctactatt ggcacagaag cctggaaaaa 541 attcatcaat gtgaaaacat ctttagagaa ggccaatact ttggttgttc ctttgatctg 601 accaaagtga aggattccag ttttgaacaa cacagtgtcc aaataatggt caaggataat 661 gcaggaaaaa ttaaaccatc cttcaatata gtgcctttaa cttcccgtgt gaaacctgat 721 cctccacata ttaaaaacct ctccttccac aatgatgacc tatatgtgca atgggagaat 781 ccacagaatt ttattagcag atgcctattt tatgaagtag aagtcaataa cagccaaact 841 gagacacata atgttttcta cgtccaagag gctaaatgtg agaatccaga atttgagaga 901 aatgtggaga atacatcttg tttcatggtc cctggtgttc ttcctgatac tttgaacaca 961 gtcagaataa gagtcaaaac aaataagtta tgctatgagg atgacaaact ctggagtaat 1021 tggagccaag aaatgagtat aggtaagaag cgcaattcca 6actctacat aaccatgtta 1081 ctcattgttc cagtcatcgt cgcaggtgca atcatagtac tcctgcttta cctaaaaagg 1141 ctcaagatta ttatattccc tccaattcct gatcctggca agatttttaa agaaatgttt 1201 ggagaccaga atgatgatac tctgcactgg aagaagtacg acatctatga gaagcaaacc 1261 aaggaggaaa ccgactctgt agtgctgata gaaaacctga agaaagcctc tcagtgatgg 1321 agataattta tttttacctt cactgtgacc ttgagaagat tcttcccatt ctccatttgt 1381 tatctgggaa cttattaaat ggaaactgaa actactgcac catttaaaaa caggcagctc 1441 ataagagcca caggtcttta tgttgagtcg cgcaccgaaa aactaaaaat aatgggcgct 1501 ttggagaaga gtgtggagtc attctcattg aattataaaa gccagcaggc ttcaaactag 1561 gggacaaagc aaaaagtgat gatagtggtg gagttaatct tatcaagagt tgtgacaact 1621 tcctgaggga catacttg ctttgtgttc tttgtgtcaa catgaacaaa ttttatttgt 1681 aggggaactc atttggggtg caaatgctaa tgtcaaactt gagtcacaaa gaacatgtag 1741 aaaacaaaat ggataaaatc tgatatgtat tgtttgggat cctattgaac catgtttgtg 1801 gctattaaaa ctcttttaac agtctgggct gggtccggtg gctcacgcct gtaatcccag 1861 caatttggga gtccgaggcg ggcggatcac tcgaggtcag gagttccaga ccagcctgac 1921 caaaatggtg aaacctcctc tctactaaaa ctacaaaaat taactgggtg tggtggcgcg 1981 tgcctgtaat cccagctact cgggaagctg aggcaggtga attgtttgaa cctgggaggt 2041 ggaggttgca gtgagcagag atcacaccac tgcactctag cctgggtgac agagcaagac 2101 tctgtctaaa aaacaaaaca aaacaaaaca aaacaaaaaa acctcttaat attctggagt 2161 catcattccc ttcgacagca ttttcctctg ctttgaaagc cccagaaatc agtgttggcc 2221 atgatgacaa ctacagaaaa accagaggca gcttctttgc caagaccttt caaagccatt 2281 ttaggctgtt aggggcagtg gaggtagaat gactccttgg gtattagagt ttcaaccatg 2341 aaatctctaa caatgtattt tcttcacctc tgctactcaa gtagcattta ctgtgtcttt 2401 gctttgtgct aggcccccgg gtgtgaagca cagacccctt ccaggggttt acagtctatt 2461 tgagactcct cagttcttgc cacttttttt tttaatctcc accagtcatt tttcagacct 2521 tttaactcct caattccaac actgatttcc ccttttgcat tctccctcct tcccttcctt 2581 gtagcctttt gactttcatt ggaaattagg atgtaaatct gctcaggaga cctggaggag 2641 cagaggataa ttagcatctc aggttaagtg tgagtaatct gagaaacaat gactaattct 2701 tgcatatttt gtaacttcca gtgagggtt ttcagcattg atatttgtgc attttctaaa 2761 cagagatgag gtggtatctt cacgtagaac attggtattc gcttgagaaa aaaagaatag 2821 ttgaacctat ttctctttct ttacaagatg ggtccaggat tcctcttttc tctgccataa 2881 atgattaatt aaatagcttt tgtgtcttac attggtagcc agccagccaa ggctctgttt 2941 atgcttttgg ggggcatata ttgggttcca ttctcaccta tccacacaac atatccgtat 3001 atatcccctc tactcttact tcccccaaat ttaaagaagt atgggaaatg agaggcattt 3061 cccccacccc atttctctcc tcacacacag actcatatta ctggtaggaa cttgagaact 3121 ttatttccaa gttgttcaaa catttaccaa tcatattaat acaatgatgc tatttgcaat 3181 cccgctcct aggggagggg agaaagaaa ccctcactct ctacaggttt gggtacaagt 3241 ggcaacctgc ttccatggcc tgtagaagc atggtgccct ggcttctctg aggaagctgg WO 00/09525 PCT/US99/17712 EPI-109 1253 3301 ggttcatgac aatagcagar ataaagttat tcttgaagtc agat-gaggc tgggagacag 3361 ccgtagtaga tgttctacz: tgttctgctg ttctctagaa agaatatttg gttttcctgt 3421 ataggaatga gattaattcc tttccaggta ttttataatt ctgggaagca aaacccatgc 3481 ctccccctag ccatttttac tgttatccta tttagatggc cargaagagg atgctgtgaa 3541 attcccaaca aacattgatg ctgacagtca tgcagtctgg gagtggggaa gtgatctttt 3601 gttcccatcc tcttctttta qcagtaaaat agctgaggga aaaaggaggg aaaaggaagt 3661 tatgggaata cctgtggtgg ttgtgatccc taggtcttag gagctcttgg aggtgtctgt 3721 atcagtggat ttcccatccc ctatgggaaa ttagtaggct catttactgt tttaggtcta 3781 gcctatgtgg attttttcct aacataccta agcaaaccca gtgtcaggat ggtaattctt 3841 attctttcgt tcagttaaat ttttcccttc atctgggcac tgaagggata tgtgaaacaa 3901 tgttaacatt tttggtagtc ttcaaccagg gattgtttct gtttaacttc ttataggaaa 3961 gcttgagtaa aataaatatt gtctttttgt atgtcaccc (2) INFORMATION FOR SEQ ID NO:88: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 4039 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:88: 1 tgccaaggct ccagcccggc cgggctccga ggcgagaggc tgcatggagt ggccggcgcg 61 gctctgcggg ctgtgggcgc tgctgctctg cgccggcggc gggggcgggg gcgggggcgc 121 cgcgcctacg gaaactcagc cacctgtgac aaatttgagt gtctctgttg aaaacctctg 181 cacagtaata tggacatgga atccacccga gggagccagc tcaaattgta gtctatggta 241 ttttagtcat tttggcgaca aacaagataa gaaaatagct ccggaaactc gtcgttcaat 301 agaagtaccc ctgaatgaga ggatttgtct gcaagtgggg tcccagtgta gcaccaatga 361 gagtgagaag cctagcattt tggttgaaaa atgcatctca cccccagaag gtgatcctga 421 gtctgctgtg actgagcttc aatgcatttg gcacaacctg agctacatga agtgttcttg 481 gctccctgga aggaatacca gtcccgacac taactatact ctctactatt ggcacagaag 541 cctggaaaaa attcatcaat gtgaaaacat ctttagagaa ggccaatact ttggttgttc 601 ctttgatctg accaaagtga aqgattccag ttttgaacaa cacagtgtcc aaataatggt 661 caaggataat gcaggaaaaa ttaaaccatc cttcaatata gtgcctttaa cttcccgtgt 721 gaaacctgat cctccacata ttaaaaacct ctccttccac aatgatgacc tatatgtgca 781 atgggagaat ccacagaatt ttattagcag atgcctattt tatgaagtag aagtcaataa 841 cagccaaact gagacacata atgttttcta cgtccaagag gctaaatgtg agaatccaga 901 atttgagaga aatgtggaga atacatcttg tttcatggtc cctggtgttc ttcctgatac 961 tttgaacaca gtcagaataa gagtcaaaac aaataagtta tgctatgagg atgacaaact 1021 ctggagtaat tggagccaag aaatgagtat aggtaagaag cgcaattcca cactctacat 1081 aaccatgtta ctcattgttc cagtcatcgt cgcaggtgca atcatagtac tcctgcttta 1141 cctaaaaagg ctcaagatta ttatattccc tccaattcct gatcctggca agatttttaa 1201 agaaatgttt ggagaccaga atgatgatac tctgcactgg aagaagtacg acatctatga 1261 gaagcaaacc aaggaggaaa ccgactctgt agtgctgata gaaaacctga agaaagcctc 1321 tcagtgatgg agataattta tttttacctt cactgtgacc ttgagaagat tcttcccatt 1381 ctccatttgt tatctgggaa cttattaaat ggaaactgaa actactgcac catttaaaaa 1441 caggcagctc ataagagcca caggtcttta tgttgagtcg cgcaccgaaa aactaaaaat 1501 aatgggcgct ttggagaaga gtgtggagtc attctcattg aattataaaa gccagcaggc 1561 ttcaaactag gggacaaagc aaaaagtgat gatagtggtg gagttaatct tatcaagagt 1621 tgtgacaact tcctgaggga tctatacttg ctttgtgttc tttgtgtcaa catgaacaaa 1681 ttttatttgt aggggaactc atttggggtg caaatgctaa tgtcaaactt gagtcacaaa 1741 gaacatgtag aaaacaaaat ggataaaatc tgatatgtat tgtttgggat cctattgaac 1801 catgtttgtg gctattaaaa ctcttttaac agtctgggct gggtccggtg gctcacgcct 1861 gtaatcccag caatttggga gtccgaggcg ggcggatcac tcgaggtcag gagttccaga 1921 ccagcctgac caaaatggtg aaacctcctc tctactaaaa ctacaaaaat taactgggtg 1981 tggtggcgcg tgcctgtaat cccagctact cgggaagctg aggcaggtga attgtttgaa 2041 cctgggaggt ggaggttgca gtgagcagag atcacaccac tgcactctag cctgggtgac 2101 agagcaagac tctgtctaaa aaacaaaaca aaacaaaaca aaacaaaaaa acctcttaat 2161 attctggagt catcattccc ttcgacagca ttttcctctg ctttgaaagc cccagaaatc 2221 agtgttggcc atgatgacaa ctacagaaaa accagaggca gcttctttgc caagaccttt 2281 caaagccatt ttaggctgtt aggggcagtg gaggtagaat gactccttgg gtattagagt 2341 ttcaaccatg aagtctctaa caatgtattt tcttcacctc tgctactcaa gtagcattta 2401 ctgtgtcttt ggtttgtgct aggcccccgg gtgtgaagca cagacccctt ccaggggttt 2461 acagtctatt tgagactcct cagttcttgc cacttttttt tttaatctcc accagtcatt 2521 tttcagacct tttaactcct caattccaac actgatttcc ccttttgcat tctccctcct 2581 tcccttcctt gtagcctttt gactttcatt ggaaattagg atgtaaatct gctcaggaga 2641 cctggaggag cagaggataa ttagcatctc aggttaagtg tgagtaatct gagaaacaat 2701 gactaattct tgcatatttt gtaacttcca tgtgagggtt ttcagcattg atatttgtgc 2761 attttctaaa cagagatgag gtggtatctt cacgtagaac attggtattc gcttgagaaa 2821 aaaagaatag ttgaacctat ttctctttct ttacaagatg ggtccaggat tcctcttttc 2881 tctgccataa atgattaatt aaatagcttt tgtgtcttac attggtagcc agccagccaa 2941 ggctctgttt atgcttttgg ggggcatata ttgggttcca ttctcaccta tccacacaac 3001 atatccgtat atatcccctc tactcttact tcccccaaat ttaaagaagt atgggaaatg 3061 agaggcattt cccccacccc atttctctcc tcacacacag actcatatta ctggtaggaa 3121 cttgagaact ttatttccaa gttgttcaaa catttaccaa tcatattaat acaatgatgc 3181 tatttgcaat tcctgctcct aggggagggg agataagaaa ccctcactct ctacaggttt 3241 gggtacaagt ggcaacctgc ctccatggcc gtgtagaagc atggtgccct ggcttctctg WO 00/09525 PCTIUS99/17712 EPI-109 1254 3301 aggaagctgg ggztcatgac aatggcagat gtaaagttat tcttgaagtc agattgaggc 3361 tgggagacag ccgtagtaga tgttctactt tgttctgctg ttctctagaa agaatatttg 3421 gttttcctgt ataggaatga gattaattcc tttccaggta ttttataart ctgggaagca 3481 aaacccatgc ctccccctag ccatttttac tgttatccta tttagatggc catgaagagg 3541 atgctgtgaa attcccaaca aacattgatg ctgacagtca tgcagtctgg gagtggggaa 3601 gtgatctttt gttcccatcc tcttctttta gcagtaaaat agctgaggga aaagggaggg 3661 aaaaggaagt tatgggaata cctgtggtgg ttgtgatccc taggtcttgg gagctcttgg 3721 aggtgtctgt atcagtggat ttcccatccc ctgtgggaaa ttagtaggct catttactgt 3781 tttaggtcta gcctatgtgg attttttcct aacataccta agcaaaccca gtgtcaggat 3841 ggtaattc attctttcgt tcagttaagt ttttcccttc atctgggcac tgaagggata 3901 tgtgaaacaa tgttaacatt tttggtagtc ttcaaccagg gattgtttct gtttaacttc 3961 ttataggaaa gcttgagtaa aataaatatt gtctttttgt atgtcaacg ggccgccacc 4021 gcggtggaaa ccccagctt (2) INFORMATION FOR SEQ ID NO:89: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 5670 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:89: 1 ggatccccgc tgacaatcta gaaacaagca acagaccctc tgatgtagcc atctgtgccg 61 cgcctctccg caccgcccgc cacgccttgg tccctggaga ccaccctcca gggcaggggc 121 tgccgctcgg ccgggcccgc ggggtccctc ggcctgacat ggccggtgct ggagcggcac 181 gtgcgcgcct cggcccctcg gccgctcccg cccctcgccg gtgcgcaccg gcgctcgggg 241 agccgctggc ccgggtgtcc agccggccct tgccctgcct ggcgctcgga ccgccacctt 301 tgccgccccc tcgccagcct ccgcagcttc cagactggcc ggtctgcgcg cccacccctg 361 cctcccggac cggccaccgc cggaggccgc ggaggagggc ccggccgcgc agatcccgct 421 tatcgggccc catctcccgt tacataaggc caccccccta tctccgcggg ccatcgccgc 481 cgcaaccgcc gcgccagcgc cttctcccac gcgcgggggc gcccctgccc accgctcccg 541 gcagggcttt tggtggccat gggggataag gggcgttgac tcacccgggc ggggctccgg 601 gagttgcaca gaccaaggta gttccccgct ccttccccca tcacggagac cctgtgggag 661 atgccgtggg ccctctacta cagattagga aacaggcccg tagaggggtc gcgcggccaa 721 gtagcggcac tccaggcact gggggccctc gagggaaggg gcagacttct gggagtcaga 781 gccagcagct gggctgggaa gcttcgagtg tggacagaga gggtgggaat gacgttccct 841 gtgggaagag agggtgggca agcctgggat gcctctgagc gggaatccag catgccttgt 901 gaggagggtc acaagcacac ccttgtgagg aggttgagcc ccatcgagga caggacggag 961 ggagcctgag caggcagaga gggggcctgg ggaggcgctg gttcggggag gaagtgggta 1021 ggggagaaat cttgacatca acacccaaca ggcaaatgcc gtggcctctg ctgtgggggt 1081 ttctggagga cttctaggaa aacgagggaa gagcaggaaa aggcgacatg gctgtagggc 1141 caagcccagg agccgccctc cacagcactc attctgcaga agggaaattt gaggccccca 1201 gacggcaggg gttgatcctg cagagactgg tgagcaaagg ggatcacccc aagccccagt 1261 ggcactagga acacttacaa tctctgacct ggactaaggc tgccagcctg gcccagttaa 1321 gagtttccca gaaggatggc ccatacactt taaattaaag gggccagaca cgtgcacact 1381 acttccagcc actctggaag ctgaggtggg gggatcgctt gagtctggga gttggaggcc 1441 agcctaggca ggcaacatag tgagacccca tctccaaaaa aacaaaacaa aacaaaacaa 1501 aaaaacacca aaaaagctcc cagaaagacc tctgaatctt tctggatctc tcagtggaga 1561 cctggaaatc tgaactttga caatccctct cacagtgggg ccaaggagga attaggcaag 1621 ccaaaagaag tgaactttac tcttctattg cctgtttgaa ttttgtatcc aagcaagtgt 1681 tacttaagta atttaagaga ctggttcatc gaaaaaataa aactccccaa attcccatag 1741 ctggtagact gtggtcacag ccacagtgca ctaagactat ctgctcagca cttctggtga 1801 cccaaaaggg tctgaggaca ggagctcaga gttgggtcag ctgtccaggt actcagggtt 1861 gtcacaggca aaactgctgg aactcagggc agcattgcaa atgccacgcc gctctcaggg 1921 ccccttgcct gccgctggaa ttaaacccac ccagatcttg gaaactctgc cctggaccct 1981 tctcaataag tccatgagaa atcaaactct ttcctttatg cgacactgga ttttccacaa 2041 agtaaaatca agatgagtaa agatgtggtt tctagatagt gcctgaaaaa gcagagacca 2101 tggtgtcagg cgtcaccact tgggcctata aaagctgcca caagacgcca aggccacaag 2161 ccacccagcc tatgcatccg ctcctcaatc ctctcctgtt ggcactgggc ctcatggcgc 2221 ttttgttgac cacggtcatt gctctcactt gccttggcgg ctttgcctcc ccaggccctg 2281 tgcctccctc tacagccctc agggagctca ttgaggagct ggtcaacatc acccagaacc 2341 agaaggtgag tgtcggctag ccagggtcct agctatgagg gctccagggt gggtgattcc 2401 caagatgagg tcatgagcag gctgggcctg gtcctaagat gcctgtaggt caggaaaaat 2461 ctccatggac caaggcccgg cccagccatg agggagagag gagctgggct ggggggctca 2521 gcactgtgga tggacctatg gaggtgtctg gcagactccc cagggactac ctgctctcct 2581 ggcctggcct tgtctgccac tgccagctcc tactcagcca ttcctgaaca gaggacagca 2641 gagaagggcc agcaccctcc cagaaccatg tggcatttgc caactggatt ttgaccataa 2701 caatgcagcc attctcccca gcaccatcat aggcccgccc ttacaggagg attcgttagt 2761 agagtccgct ccttgcccca ctagtaacag ctcacatgtc tgagcactgc ttacaccagg 2821 cctggtgcac gtgctttatg tgtcatttca tcactgccag ccacctcaag aggcaggtac 2881 gacgaaccca ttctgctaag gttcagtgag gttaagtgac agaggctgga ttcaagccag 2941 gcctggccaa caccagagtg tccatgctcc taactgcagt gttccctcac catcagaagg 3001 cagggcattt aatacaccag atccccaccg cctcccatct gatttgtctt ggtcaacagt 3061 ggcccaggcc actcctactt cactcgtccc caccctggcc cttcccgcag gcccctgtcc 3121 tcctgccctq accatggcaa gccttgcatg cagcttgtcc cttactagtg gtgtcaattt 3181 ttttctctca gctccaagac cctaaacagt gggacctcac ccctatgcct gctgttcaaa WO 00/09525 PCT/US99/17712 EPI-109 1255 3241 gcagaaaacg aaactcagga acactgaagg gctgccaggc ctgcctctgt gccacaccag 3301 ggatgcttgt ggggcctgtg ctggggcaga cctggcctgg gctgccaggg caggcccaca 3361 acccctgcca gcactctgct cactgtcact ttgctcccac aggctccgct ctgcaatggc 3421 agcatggtat ggagcatcaa cctgacagct ggcatggtaa ggacctttgg gtgcagggag 3481 gatggggcag aggctccagg ccttgggctt aicttctctg agcctccctt ccatggctgg 3541 ggttccaagc aagcttcaag tgctctcctc cctcccgcca taatctggcc ccttcccgcc 3601 caccacccag actcacctgc gccaggcatc tcagccccat cttcctgcag actcacaaaa 3661 ggcagctgcc caagcagggc ctgacccctc ggtgtcccct ccccacagta ctgtgcagcc 3721 ctggaatccc tgatcaacgt gtcaggccgc agtgccatcg agaagaccca gaggatgctg 3781 agcggattct gcccgcacaa ggtctcagct ggggtaaggc atcccccacc ctctcacacc 3841 caccctgcac cccctcctgc caaccctggg ctcgctgaag ggaagctggc tgaatatcca 3901 tggtgtgtgt ccacccaggg gtggggccat tgtggcagca gggacgtggc cttcgggatt 3961 tacaggatct gggctcaagg gctcctaact cctacctggg cctcaatttc cacatctgta 4021 cagtagaggt actaacagta cccacctcat ggggacttcc gtgaggactg aatgagacag 4081 tccctggaaa gcccctggtt tgtgcgagtc gtcccggcct ctggcgttct actcacgtgc 4141 tgacctcttt gtcctgcagc agttttccag cttgcatgtc cgagacacca aaatcgaggt 4201 ggcccagttt gtaaaggacc tgctcttaca tttaaagaaa ctttttcgcg agggacggtt 4261 caactgaaac ttcgaaagca tcattatttg cagagacagg acctgaCtat tgaagttgca 4321 gattcatttt tctttctgat gtcaaaaatg tcttgggtag gcgggaagga gggttaggga 4381 ggggtaaaat tccttagctt agacctcagc ctgtgctgcc cgtcttcagc ctagccgacc 4441 tcagccttcc ccttgcccag ggctcagcct ggtgggcctc ctctgtccag ggccctgagc 4501 tcggtggacc cagggatgac atgtccctac acccctcccc tgccctagag cacactgtag 4561 cattacagtg ggtgcccccc ttgccagaca tgtggtggga cagggaccca cttcacacac 4621 aggcaactga ggcagacagc agctcaggca cacttcttct tggtcttatt tattattgtg 4681 tgttatttaa atgagtgtgt ttgtcaccgt tggggattgg ggaagactgt ggctgctggc 4741 acttggagcc aagggttcag agactcaggg ccccagcact aaagcagtgg accccaggag 4801 tccctggtaa taagtactgt gtacagaatt ctgctacctc actggggtcc tggggcctcg 4861 gagcctcatc cgaggcaggg tcaggagagg ggcagaacag ccgctcctgt ctgccagcca 4921 gcagccagct ctcagccaac gagtaattta ttgtttttcc tcgtatttaa atattaaata 4981 tgttagcaaa gagttaatat atagaagggt accttgaaca ctgggggagg ggacattgaa 5041 caagttgttt cattgactat caaactgaag ccagaaataa agttggtgac agataggcct 5101 gattgtattt gtctttcatt ttggcctttg gggacactgg tctgtggtct gaagactctg 5161 aggagctctt cgggaggctg gtgggttgga ggaggggact gggatggatt acagcgaggg 5221 tagggtgcag tgacctgggc tgaatgcaag ctagctcccg agggtgggga catggcctga 5281 aggaagcccc accttctgtc tgctgcacca gcaaggacgg agaggcttgg gccagactgt 5341 cagggttcaa ggagggcatc aggagcagac ggagacccag gaagtctcac aatcacatct 5401 cctgaggact ggccagctgt gtctggcacc acccacacat ccatgtctcc ctcacaaccc 5461 aggaggccga tgagaactgt gaggctcaga aagcgtgggc ggtttgccta aggtcacgta 5521 gctacttcct cactggggtc ctggggcctc agagcctcat ctgaggtaaa ggagcaaagt 5581 tgggattggg gtccaaaatt cactttaact ccaaagccca cacacttaac caccctgcct 5641 atttctgtcc aaatgtcacc tgtcctgaat (2) INFORMATION FOR SEQ ID NO:90: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14978 base pairs (B) TYPE: nucleic acid (C) STRAINDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:90: 1 ttcggcatcc gctcctcaat cctctcctgt tggcactggg cctcatggcg cttttgttga 61 ccacggtcat tgctctcact tgccttggcg gctttgcctc cccaggccct gtgcctccct 121 ctacagccct cagggagctc attgaggagc tggtcaacat cacccagaac cagaaggctc 181 cgctctgcaa tggcagcatg gtatggagca tcaacctgac agctggcatg tactgtgcag 241 ccctggaatc cctgatcaac gtgtcaggct gcagtgccat cgagaagacc cagaggatgc 301 tgagcggatt ctgcccgcac aaggtctcag ctgggcagtt ttccagcttg catgtccgag 361 acaccaaaat cgaggtggcc cagtttgtaa aggacctgct cttacattta aagaaacttt 421 ttcgcgaggg acggttcaac tgaaacttcg aaagcatcat tatttgcaga gacaggacct 481 gactattgaa gttgcagatt catttttctt tctgatgtca aaaatgtctt gggtaggcgg 541 gaaggagggt tagggagggg taaaattcct tagcttagac ctcagcctgt gctgcccgtc 601 ttcagcctag ccgacctcag ccttcccctt gcccagggct cagcctggtg ggcctcctct 661 gtccagggcc ctgagctcgg tggacccagg gatgacatgt ccctacaccc ctcccctgcc 721 ctagagcaca ctgtagcatt acagtgggtg ccccccttgc cagacatgtg gtgggacagg 781 gacccacttc acacacaggc aactgaggca gacagcagct caggcacact tcttcttggt 841 cttatttatt attgtgtgtt atttaaatga gtgtgtttgt caccgttggg gattggggaa 901 gactgtggct gctggcactt ggagccaagg gttcagagac tcagggcccc agcactaaag 961 cagtggaccc caggagtccc tggtaataag tactgtgtac agaattctgc tacctcactg 1021 gggtcctggg gcctcggagc ctcatccgag gcagggtcag gaqaggggca gaacagccgc 1081 tcctgtctgc cagccagcag ccagctctca gccaacgagt aatttattgt ttttcctcgt 1141 atttaaatat taaatatgtt agcaaagagt taatatatag aagggtacct tgaacactgg 1201 gggaggggac attgaacaag ttgtttcatt gactatcaaa ctgaagccag aaataaagtt 1261 ggtgacagat 1 tcagcccggc cgggctccga ggcgagaggc tgcatggag ggccggcgcg gctctgcggg 61 ctgtgggcgc tgctgctctg cgccggcggc gggggcgggg gcgggggcgc cgcgcctacg 121 gaaactcagc cacctgtgac aaatttgagt gtctctgttg aaaacctctg cacagtaata 181 tggacatgga atccacccga gggagccagc tcaaattgta gtctatggta ttttagtcat WO 00/09525 PCT/US99/17712 EPI-109 1256 241 tttggcgaca aacaagataa Qaaaatagct ccggaaactc gtcgttcaat agaagtaccc 301 ctgaatgaga ggatttatct gcaagtgggg tcccagtgta gcaccaatga gagtgagaag 361 cctagcattt tggttgaaaa atgcatctca cccccagaag gtgatcctga gtctgctgtg 421 actgagcttc aatgcatttg gcacaacctg agctacatga agtgttcttg gctccctgga 481 aggaatacca gtcccgacac taactatact ctctactatt ggcacagaag cctggaaaaa 541 attcatcaat gtgaaaacat ctttagagaa ggccaatact ttggttgttc ctttgatctg 601 accaaagtga aggattccag ttttgaacaa cacagtgtcc aaataatggt caaggataat 661 gcaggaaaaa ttaaaccatc cttcaatata gtgcctttaa cttcccgtgt gaaacctgat 721 cctccacata ttaaaaacct ctccttccac aatgatgacc tatatgtgca atgggagaat 781 ccacagaatt ttattagcag atgcctattt tatgaagtag aagtcaataa cagccaaact 841 gagacacata atgttttcta cgtccaagag gctaaatgtg agaatccaga atttgagaga 901 aatgtggaga atacatcttg tttcatggtc cctggtgttc ttcctgatac tttgaacaca 961 gtcagaataa gagtcaaaac aaataagtta tgctatgagg atgacaaact ctggagtaat 1021 tggagccaag aaatgagtat aggtaagaag cgcaattcca cactctacat aaccatgtta 1081 ctcattgttc cagtcatcgt cgcaggtgca atcatagtac tcctgcttta cctaaaaagg 1141 ctcaagatta ttatattccc tccaattcct gatcctggca agatttttaa agaaatgttt 1201 ggagaccaga atgatgatac tctgcactgg aagaagtacg acatctatga gaagcaaacc 1261 aaggaggaaa ccgactctgt agtgctgata gaaaacctga agaaagcctc tcagtgatgg 1321 agataattta tttttacctt cactgtgacc ttgagaagat tcttcccatt ctccatttgt 1381 tatctgggaa cttattaaat ggaaactgaa actactgcac catttaaaaa caggcagctc 1441 ataagagcca caggtcttta tgttgagtcg cgcaccgaaa aactaaaaat aatgggcgct 1501 ttggagaaga gtgtggagtc attctcattg aattataaaa gccagcaggc ttcaaactag 1561 gggacaaagc aaaaagtgat gatagtggtg gagttaatct tatcaagagt tgtgacaact 1621 tcctgaggga tctatacttg ctttgtgttc tttgtgtcaa catgaacaaa ttttatttgt 1681 aggggaactc atttggggtg caaatgctaa tgtcaaactt gagtcacaaa gaacatgtag 1741 aaaacaaaat ggataaaatc tgatatgtat tgtttgggat cctattgaac catgtttgtg 1801 gctattaaaa ctcttttaac agtctgggct gggtccggtg gctcacgcct gtaatcccag 1861 caatttggga gtccgaggcg ggcggatcac tcgaggtcag gagttccaga ccagcctgac 1921 caaaatggtg aaacctcctc tctactaaaa ctacaaaaat taactgggtg tggtggcgcg 1981 tgcctgtaat cccagctact cgggaagctg aggcaggtga attgtttgaa cctgggaggt 2041 ggaggttgca gtgagcagag atcacaccac tgcactctag cctgggtgac agagcaagac 2101 tctgtctaaa aaacaaaaca aaacaaaaca aaacaaaaaa acctcttaat attctggagt 2161 catcattccc ttcgacagca ttttcctctg ctttgaaagc cccagaaatc agtgttggcc 2221 atgatgacaa ctacagaaaa accagaggca gcttctttgc caagaccttt caaagccatt 2281 ttaggctgtt aggggcagtg gaggtagaat gactccttgg gtattagagt ttcaaccatg 2341 aagtctctaa caatgtattt tcttcacctc tgctactcaa gtagcattta ctgtgtcttt 2401 ggtttgtgct aggcccccgg gtgtgaagca cagacccctt ccaggggttt acagtctatt 2461 tgagactcct cagttcttgc cacttttttt tttaatctcc accagtcatt tttcagacct 2521 tttaactcct caattccaac actgatttcc ccttttgcat tctccctcct tcccttcctt 2581 gtagcctttt gactttcatt ggaaattagg atgtaaatct gctcaggaga cctggaggag 2641 cagaggataa ttagcatctc aggttaagtg tgagtaatct gagaaacaat gactaattct 2701 tgcatatttt gtaacttcca tgtgagggtt ttcagcattg atatttgtgc attttctaaa 2761 cagagatgag gtggtatctt cacgtagaac attggtattc gcttgagaaa aaaagaatag 2821 ttgaacctat ttctctttct ttacaagatg ggtccaggat tcctcttttc tctgccataa 2881 atgattaatt aaatagcttt tgtgtcttac attggtagcc agccagccaa ggctctgttt 2941 atgcttttgg ggggcatata ttgggttcca ttctcaccta tccacacaac atatccgtat 3001 atatcccctc tactcttact tcccccaaat ttaaagaagt atgggaaatg agaggcattt 3061 cccccacccc atttctctcc tcacacacag actcatatta ctggtaggaa cttgagaact 3121 ttatttccaa gttgttcaaa catttaccaa tcatattaat acaatgatgc tatttgcaat 3181 tcctgctcct aggggagggg agataagaaa ccctcactct ctacaggttt gggtacaagt 3241 ggcaacctgc ttccatggcc gtgtagaagc atggtgccct ggcttctctg aggaagctgg 3301 ggttcatgac aatggcagat gtaaagttat tcttgaagtc agattgaggc tgggagacag 3361 ccgtagtaga tgttctactt tgttctgctg ttctctagaa agaatatttg gttttcctgt 3421 ataggaatga gattaattcc tttccaggta ttttataatt ctgggaagca aaacccatgc 3481 ctccccctag ccatttttac tgttatccta tttagatggc catgaagagg atgctgtgaa 3541 attcccaaca aacattgatg ctgacagtca tgcagtctgg gagtggggaa gtgatctttt 3601 gttcccatcc tcttctttta gcagtaaaat agctgaggga aaagggaggg aaaaggaagt 3661 tatgggaata cctgtggtgg ttgtgatccc taggtcttgg gagctcttgg aggtgtctgt 3721 atcagtggat ttcccatccc ctgtgggaaa ttagtaggct catttactgt tttaggtcta 3781 gcctatgtgg attttttcct aacataccta agcaaaccca gtgtcaggat ggtaattctt 3841 attctttcgt tcagttaagt ttttcccttc atctgggcac tgaagggata tgtgaaacaa 3901 tgttaacatt tttggtagtc ttcaaccagg gattgtttct gtttaacttc ttataggaaa 3961 gcttgagtaa aataaatatt gtctttttgt atgtcaccc 1 tgccaaggct ccagcccggc cgggctccga ggcgagaggc tgcatggagt ggccggcgcg 61 gctctgcggg ctgtgggcgc tgctgctctg cgccggcggc gggggcgggg gcgggggcgc 121 cgcgcctacg gaaactcagc cacctgtgac aaatttgagt gtctctgttg aaaacctctg 181 cacagtaata tggacatgga atccacccga gggagccagc tcaaattgta gtctatggta 241 ttttagtcat tttggcgaca aacaagataa gaaaatagct ccggaaactc gtcgttcaat 301 agaagtaccc ctgaatgaga ggatttgtct gcaagtgggg tcccagtgta gcaccaatga 361 gagtgagaag cctagcattt tggttgaaaa atgcatctca ccccagaag gtgatcctga 421 gtctgctgtg actgagcttc aatgcatttg gcacaacctg agctacatga agtgttcttg 481 gctccctgga aggaatacca gtcccgacac taactatact ctctactatt ggcacagaag 541 cctggaaaaa attcatcaat gtgaaaacat ctttagagaa ggccaatact ttggttgttc 601 ctttgatctg accaaagtga aggattccag ttttgaacaa cacagtgtcc aaataatggt 661 caaggataat gcaggaaaaa ttaaaccatc cttcaatata gtgcctttaa cttcccgtgt WO 00/09525 PCTIUS99/17712 EPI-109 1257 721 gaaacctgat cctccacata ttaaaaacct ctccttccac aatgatgacc tatatgtgca 781 atgggagaat ccacagaatt ttattagcag atgcctattt tatgaaatag aagtcaataa 841 cagccaaact gagacacata atgttttcta cgtccaagag gctaaatgtg agaatccaga 901 atttgagaga aatgtggaga atacatcttg tttcatggtc cctggtgttc ttcctgatac 961 tttgaacaca gtcagaataa gagtcaaaac aaataaatta tgctatgagg atgacaaact 1021 ctggagtaat tggagccaag aaatgagtat aggtaagaag cgcaattcca cactctacat 1081 aaccatgtta ctcattgttc cagtcatcgt cgcaggtgca atcatagtac tcctgcttta 1141 cctaaaaagg ctcaagatta ttatattccc tccaattcct gatcctagca agatttttaa 1201 agaaatgttt ggagaccaga atgatgatac tctgcactgg aagaagtacg acatctatga 1261 gaagcaaacc aaggaggaaa ccgactctgt agtgctgata gaaaacctga agaaagcctc 1321 tcagtgatgg agataattta tttttacctt cactgtgacc ttgagaagat tcttcccatt 1381 ctccatttgt tatctgggaa cttattaaat ggaaactgaa actactgcac catttaaaaa 1441 caggcagctc ataagagcca caggtcttta tgttgagtcg cgcaccgaaa aactaaaaat 1501 aatgggcgct ttggagaaga gtgtggagtc attctcattg aattataaaa gccagcaggc 1561 ttcaaactag gggacaaagc aaaaagtgat gatagtggtg gagttaatct tatcaagagt 1621 tgtgacaact tcctgaggga tctatacttg ctttgtgttc tttgtgtcaa catgaacaaa 1681 ttttatttgt aggggaactc atttggggtg caaatgctaa tgtcaaactt gagtcacaaa 1741 gaacatgtag aaaacaaaat ggataaaatc tgatatgtat tgtttgggat cctattgaac 1801 catgtttgtg gctattaaaa ctcttttaac agtctgggct gggtccagtg gctcacgcct 1861 gtaatcccag caatttggga gtccgaggcg ggcggatcac tcgaggtcag gagttccaga 1921 ccagcctgac caaaatggtg aaacctcctc tctactaaaa ctacaaaaat taactgggtg 1981 tggtggcgcg tgcctgtaat cccagctact cgggaagctg aggcaggtga attgtttgaa 2041 cctgggaggt ggaggttgca gtgagcagag atcacaccac tgcactctag cctgggtgac 2101 agagcaagac tctgtctaaa aaacaaaaca aaacaaaaca aaacaaaaaa acctcttaat 2161 attctggagt catcattccc ttcgacagca ttttcctctg ctttgaaagc cccagaaatc 2221 agtgttggcc atgatgacaa ctacagaaaa accagaggca gcttctttgc caagaccttt 2281 caaagccatt ttaggctgtt aggggcagtg gaggtagaat gactccttgg gtattagagt 2341 ttcaaccatg aagtctctaa caatgtattt tcttcacctc tgctactcaa gtagcattta 2401 ctgtgtcttt ggtttgtgct aggcccccgg gtgtgaagca cagacccctt ccaggggttt 2461 acagtctatt tgagactcct cagttcttgc cacttttttt tttaatctcc accagtcatt 2521 tttcagacct tttaactccc caattccaac actgatttcc ccttttgcat tctccctcct 2581 tcccttcctt gtagcctttt gactttcatt ggaaattagg atgtaaatct gctcaggaga 2641 cctggaggag cagaggataa ttagcatctc aggttaagtg tgagtaatct gagaaacaat 2701 gactaattct tgcatatttt gtaacttcca tgtgagggtt ttcagcattg atatttgtgc 2761 attttctaaa cagagatgag gtggtatctt cacgtagaac attggtattc gcttgagaaa 2821 aaaagaatag ttgaacctat ttctctttct ttacaagatg ggtccaggat tcctcttttc 2881 tctgccataa atgattaatt aaatagcttt tgtgtcttac attggtagcc agccagccaa 2941 ggctctgttt atgcttttgg ggggcatata ttgggttcca ttctcaccta tccacacaac 3001 atatccgtat atatcccctc tactcttact tcccccaaat ttaaagaagt atgggaaatg 3061 agaggcattt cccccacccc atttctctcc tcacacacag actcatatta ctggtaggaa 3121 cttgagaact ttatttccaa gttgttcaaa catttaccaa tcatattaat acaatgatgc 3181 tatttgcaat tcctgctcct aggggagggg agataagaaa ccctcactct ctacaggttt 3241 gggtacaagt ggcaacctgc ttccatggcc gtgtagaagc atggtgccct ggcttctctg 3301 aggaagctgg ggttcatgac aatggcagat gtaaagttat tcttgaagtc agattgaggc 3361 tgggagacag ccgtagtaga tgttctactt tgttctgctg ttctctagaa agaatatttg 3421 gttttcctgt ataggaatga gattaattcc tttccaggta ttttataatt ctgggaagca 3481 aaacccatgc ctccccctag ccatttttac tgttatccta tttagatggc catgaagagg 3541 atgctgtgaa attcccaaca aacattgatg ctgacagtca tgcagtctgg gagtggggaa 3601 gtgatctttt gttcccatcc tcttctttta gcagtaaaat agctgaggga aaagggaggg 3661 aaaaggaagt tatgggaata cctgtggtgg ttgtgatccc taggtcttgg gagctcttgg 3721 aggtgtctgt atcagtggat ttcccatccc ctgtgggaaa ttagtaggct catttactgt 3781 tttaggtcta gcctatgtgg attttttcct aacataccta agcaaaccca gtgtcaggat 3841 ggtaattctt attctttcgt tcagttaagt ttttcccttc atctgggcac tgaagggata 3901 tgtgaaacaa tgttaacatt tttggtagtc ttcaaccagg gattgtttct gtttaacttc 3961 ttataggaaa gcttgagtaa aataaatatt gtctttttgt atgtcaagcg ggccgccacc 4021 gcggtggaaa ctccagctt 1 ggatccccgc tgacaatcta gaaacaagca acagaccctc tgatgtagcc atctgtgccg 61 cgcctctccg caccgcccgc cacgccttgg tccctggaga ccaccctcca gggcaggggc 121 tgccgctcgg ccgggcccgc ggggtccctc ggcctgacat ggccggtgct ggagcggcac 181 gtgcgcgcct cggcccctcg gccgctcccg cccctcgccg gtgcgcaccg gcgctcgggg 241 agccgctggc ccgggtgtcc agccggccct tgccctgcct ggcgctcgga ccgccacctt 301 tgccgccccc tcgccagcct ccgcagcttc cagactggcc ggtctgcgcg cccacccctg 361 cctcccggac cggccaccgc cggaggccgc ggaggagggc ccggccgcgc agatcccgct 421 tatcgggccc catctcccgt tacataaggc caccccccta tctccgcggg ccatcgccgc 481 cgcaaccgcc gcgccagcgc cttctcccac gcgcgggggc gcccctgccc accgctcccg 541 gcagggcttt tggtggccat gggggataag gggcgttgac tcacccgggc ggggctccgg 601 gagttgcaca gaccaaggta gttccccgct ccttccccca tcacggagac cctgtgggag 661 atgccgtggg ccctctacta cagattagga aacaggcccg tagaggggtc gcgcggccaa 721 gtagcggcac tccaggcact gggggccctc gagggaaggg gcagacttCt gggagtcaga 781 gccagcagct gggctgggaa gcttcgagtg tggacagaga gggtgggaat gacgttccct 841 gtgggaagag agggtgggca agcctgggat gcctctgagc gggaatccag catgccttgt 901 gaggagggtc acaagcacac ccttgtgagg aggttgagcc Ccatcgagga caggacggag 961 ggagcctgag caggcagaga gggggcctgg ggaggcgctg gttcggggag gaagtgggta 1021 ggggagaaat cttgacatca acacccaaca ggcaaatgcc gtggcctctg ctgtgggggt 1081 ttctggagga cttctaggaa aacgagggaa gagcaggaaa aggcgacatg gctgtagggc WO 00/09525 PCT/US99/17712 EPI-109 1258 1141 caaacccagg agccgccctc cacagcactc attctgcaga agggaaattt gaggCCCCCa 1201 gacggcaggg gttgatcctg cagagactgg tgagcaaagg ggatcacccc aagccccagt 1261 ggcactagga acacttacaa tctctgacct ggactaaggc tgccagcctg gcccagttaa 1321 gagtttccca gaaggatggc ccatacactt taaattaaag gggccagaca cgtgcacact 1381 acttccagcc actctggaag ctgaggtggg gggatcgctt gagtctggga gttggaggcc 1441 agcctaggca ggcaacatag tgagacccca tctccaaaaa aacaaaacaa aacaaaacaa 1501 aaaaacacca aaaaagctcc cagaaagacc tctgaatctt tctggatctc tcagtggaga 1561 cctggaaatc tgaactttga caatccctct cacagtgggg ccaaggagga attaggcaag 1621 ccaaaagaag tgaactttac tcttctattg cctgtttgaa ttttgtatcc aagcaagtgt 1681 tacttaagta atttaagaga ctggttcatc gaaaaaataa aactccccaa attcccatag 1741 ctggtagact gtggtcacag ccacagtgca ctaagactat ctgctcagca cttctggtga 1801 cccaaaaggg tctgaggaca ggagctcaga gttgggtcag ctgtccaggt actcagggtt 1861 gtcacaggca aaactgctgg aactcagggc agcattgcaa atgccacgcc gctctcaggg 1921 ccccttgcct gccgctggaa ttaaacccac ccagatcttg gaaactctgc cctggaccct 1981 tctcaataag tccatgagaa atcaaactct ttcctttatg cgacactgga ttttccacaa 2041 agtaaaatca agatgagtaa agatgtggtt tctagatagt gcctgaaaaa gcagagacca 2101 tggtgtcagg cgtcaccact tgggcctata aaagctgcca caagacgcca aggccacaag 2161 ccacccagcc tatgcatccg ctcctcaatc ctctcctgtt ggcactgggc ctcatggcgc 2221 ttttgttgac cacggtcatt gctctcactt gccttggcgg ctttgcctcc ccaggccctg 2281 tgcctccctc tacagccctc agggagctca ttgaggagct ggtcaacatc acccagaacc 2341 agaaggtgag tgtcggctag ccagggtcct agctatgagg gctccagggt gggtgattcc 2401 caagatgagg tcatgagcag gctgggcctg gtcctaagat gcctgtaggt caggaaaaat 2461 ctccatggac caaggcccgg cccagccatg agggagagag gagctgggct ggggggctca 2521 gcactgtgga tggacctatg gaggtgtctg gcagactccc cagggactac ctgctctcct 2581 ggcctggcct tgtctgccac tgccagctcc tactcagcca ttcctgaaca gaggacagca 2641 gagaagggcc agcaccctcc cagaaccatg tggcatttgc caactggatt ttgaccataa 2701 caatgcagcc attctcccca gcaccatcat aggcccgccc ttacaggagg attcgttagt 2761 agagtccgct ccttgcccca ctagtaacag ctcacatgtc tgagcactgc ttacaccagg 2821 cctggtgcac gtgctttatg tgtcatttca tcactgccag ccacctcaag aggcaggtac 2881 gatgaaccca ttctgctaag gttcagtgag gttaagtgac agaggctgga ttcaagccag 2941 gcctggccaa caccagagtg tccatgctcc taactgcagt gttccctcac catcagaagg 3001 cagggcattt aatacaccag atccccaccg cctcccatct gatttgtctt ggtcaacagt 3061 ggcccaggcc actcctactt cactcgtccc caccctggcc cttcccgcag gcccctgtcc 3121 tcctgccctg actatggcaa gccttgcatg cagcttgtcc cttactagtg gtgtcaattt 3181 ttttctctca gctccaagac cctaaacagt gggacctcac ccctatgcct gctgttcaaa 3241 gcagaaaacg aagctcagga atgctgaggg gctgccaggc ctgcctctgt gccacaccag 3301 ggatgcttgt ggggcctgtg ctggggcaga cctggcctgg gctgccaggg caggcccaca 3361 acccctgcca gcactctgct cactgtcact ttgctcccac aggctccgct ctgcaatggc 3421 agcatggtat ggagcatcaa cctgacagct ggcatggtaa ggacctttgg gtgcagggag 3481 gatggggcag aggctccagg ccttgggctt atcttctctg agcctccctt ccatggctgg 3541 ggttccaagc aagcttcaag tgctctcctc cctcccgcca taatctggcc ccttcccgcc 3601 caccacccag actcacctgc gccaggcatc tcagccccat cttcctgcag actcacaaaa 3661 ggcagctgcc caagcagggc ctgacccctc ggtgtcccct ccccacagta ctgtgcagcc 3721 ctggaatccc tgatcaacgt gtcaggctgc agtgccatcg agaagaccca gaggatgctg 3781 agcggattct gcccgcacaa ggtctcagct ggggtaaggc atcccccacc ctctcacacc 3841 caccctgcac cccctcctgc caaccctggg ctcgctgaag ggaagctggc tgaatatcca 3901 tggtgtgtgt ccacccaggg gtggggccat tgtggcagca gggacgtggc cttcgggatt 3961 tacaggatct gggctcaagg gctcctaact cctacctggg cctcaatttc cacatctgta 4021 cagtagaggt actaacagta cccacctcat ggggacttcc gtgaggactg aatgagacag 4081 tccctggaaa gcccctggtt tgtgcgagtc gtcccggcct ctggcgttct actcacgtgc 4141 tgacctcttt gtcctgcagc agttttccag cttgcatgtc cgagacacca aaatcgaggt 4201 ggcccagttt gtaaaggacc tgctcttaca tttaaagaaa ctttttcgcg agggacggtt 4261 caactgaaac ttcgaaagca tcattatttg cagagacagg acctgactat tgaagttgca 4321 gattcatttt tctttctgat gtcaaaaatg tcttgggtag gcgggaagga gggttaggga 4381 ggggtaaaat tccttagctt agacctcagc ctgtgctgcc cgtcttcagc ctagccgacc 4441 tcagccttcc ccttgcccag ggctcagcct ggtgggcctc ctctgtccag ggccctgagc 4501 tcggtggacc cagggatgac atgtccctac acccctcccc tgccctagag cacactgtag 4561 cattacagtg ggtgcccccc ttgccagaca tgtggtggga cagggaccca cttcacacac 4621 aggcaactga ggcagacagc agctcaggca cacttcttct tggtcttatt tattattgtg 4681 tgttatttaa atgagtgtgt ttqtcaccgt tggggattgg ggaagactgt ggctgctggc 4741 acttggagcc aagggttcag agactcaggg ccccagcact aaagcagtgg accccaggag 4801 tccctggtaa taagtactgt gtacagaatt ctgctacctc actggggtcc tggggcctcg 4861 gagcctcatc cgaggcaggg tcaggagagg ggcagaacag ccgctcctgt ctgccagcca 4921 gcagccagct ctcagccaac gagtaattta ttgtttttcc tcgtatttaa atattaaata 4981 tgttagcaaa gagttaatat atagaagggt accttgaaca ctgggggagg ggacattgaa 5041 caagttgttt cattgactat caaactgaag ccagaaataa agttggtgac agataggcct 5101 gattgtattt gtctttcatt ttggcctttg gggacactgg tctgtggtct gaagactctg 5161 aggagctctt cgggaggctg gtgggttgga ggaggggact gggatggatt acagcgaggg 5221 tagggtgcag tgacctgggc tgaatgcaag ctagctcccg agggtgggga catggcctga 5281 aggaagcccc accttctgtc tgctgcacca gcaaggacgg agaggcttgg gccagactgt 5341 cagggttcaa ggagggcatc aggagcagac ggagacccag gaagtctcac aatcacatct 5401 cctgaggact ggccagctgt gtctggcacc acccacacat ccatgtctcc ctcacaaccc 5461 aggaggccga tgagaactgt gaggctcaga aagcgtgggc ggtttgccta aggtcacgta 5521 gctacttcct cactggggtc ctggggcctc agagcctcat ctgaggtaaa ggagcaaagt 5581 tgggattggg gtccaaaatt cactttaact ccaaagccca cacacttaac caccctgcct WO 00/09525 PCT/US99/17712 EPI-109 1259 5641 atttctgtcc aaatgtcacc tgtcctgaat (2) INFORMATION FOR SEQ ID NO:91: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1793 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:91: 1 caacaccttc agaaataatc ctttgggtga tctcttgtca atcatttgtg caggctagag 61 aggcacctgt gaatgataag gctactgaga agcatcattg gcctggtcct ggcactacca 121 aagggcaggg gaagcgatgc ccaaggggct cctgaccagc acatcatccc acgcaaaaac 181 attctccagg tcccttgttc caggcaggaa atccccagct ctgagcgccc tgccagggct 241 ctgcctaggg acaccttttc caggtctaga gaatcaaagg agcctccaga gcagctagga 301 gggcctgagc tgaccaagca agccctgctc acaagacaaa tgcagtcaag acctgggtgt 361 attacttgtc ttgagctctg aagggcaggg aggggtctga gcctcaaatc agacagagaa 421 atgctcaagt cacttctgcc aactcactgt gatggcagct acagatgaca gcccctctca 481 agactcttca gctcacagac aagccactga cttcatctgt acacaccccc atccccaatg 541 caagcccact gtacacttac aggtataaat gcatttgcaa ggccttgcaa aatgccctat 601 gtacgtaaaa ctgacccaca aaatccaaaa ttgcaagtgc cagatgccag ccaggtcaga 661 acatcctggc ttcagcaatg ggctgctcag catgggagcc ttttatgggc caggcctggc 721 tgggctgccg ctcccttccc agcatgaccc aacaccaggc tctctaggcc ctggcggagg 781 tgggctcttg aggcccagtc tggcctgatg cttctgtgct cggtgctcct gggtagcaag 841 gcgcttctgt gaccctgggg gagctgggtg cttgagcccc aggcccctct ggcctcctct 901 cagggccact gtcagtgagg gagccctggc caccagcact caggtcctgt accctcttgt 961 tcaggtcatt gcgctctgtc tgcagtgccc ggcacagctt ctccagccgt tggattttta 1021 cctgcaggcc ctccagttct ttatcccgga ctgttttctc ctcagccatc tcaagcaggg 1081 ccttgttgct gctctcccac cgggaccggt acatggtggt ttctttctcc agcttcttga 1141 tcttcttagt catcttttcc atctcctgct tgaatgtggt gaatacctcg ctgcttttgg 1201 aaagtgtgtt ctggaactcc tcaaacttct ctgtgtatag ggcaagctgt tgcttcaggt 1261 gggtctcttg ctgcttcatc agctcacaca tcctctggga ctctactgcc tctttcagga 1321 gaaaatcctt ctcccgctgg tgccgctctt ctgcctcctt tagcatctcc tgggcctgct 1381 ggagcttggc atccaccagc tgctgttgta ggtccttgtg tttgaagact ttgtcgatat 1441 gctcctcgcg cagctcatac tgctcaatca gcttcttgag cctctcagcc agctccatgt 1501 tctcttggcg cagcttggag ttgcgctcat tgtgctgttc catctgcagc tgaatgtcat 1561 tcagtgtcac ctggaagtgc gaggtcacct ccttgcgctt ctcctcctcc tcccgggccc 1621 gctgcacacc ttcttccttg agggagcggt tgtgcccgtg cagctcacgg cataggctct 1681 caagcttgct gcgggccagg acggcttgct gtgctcaccg cgcaggtggt ccttctcttg 1741 caccagctgg ctctgctttt tctgtaggag cttcatctgc ttctgtgaat tcc (2) INFORMATION FOR SEQ ID NO: 92: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1793 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 92: 1 caacaccttc agaaataatc ctttgggtga tctcttgtca atcatttgtg caggctagag 61 aggcacctgt gaatgataag gctactgaga agcatcattg gcctggtcct ggcactacca 121 aagggcaggg gaagcgatgc ccaaggggct cctgaccagc acatcatccc acgcaaaaac 181 attctccagg tcccttgttc caggcaggaa atccccagct ctgagcgccc tgccagggct 241 ctgcctaggg acaccttttc caggtctaga gaatcaaagg agcctccaga gcagctagga 301 gggcctgagc tgaccaagca agccctgctc acaagacaaa tgcagtcaag acctgggtgt 361 attacttgtc ttgagctctg aagggcaggg aggggtctga gcctcaaatc agacagagaa 421 atgctcaagt cacttctgcc aactcactgt gatggcagct acagatgaca gcccctctca 481 agactcttca gctcacagac aagccactga cttcatctgt acacaccccc atccccaatg 541 caagcccact gtacacttac aggtataaat gcatttgcaa ggccttgcaa aatgccctat 601 gtacgtaaaa ctgacccaca aaatccaaaa ttgcaagtgc cagatgccag ccaggtcaga 661 acatcctggc ttcagcaatg ggctgctcag catgggagcc ttttatgggc caggcctggc 721 tgggctgccg ctcccttccc agcatgaccc aacaccaggc tctctaggcc ctggcggagg 781 tgggctcttg aggcccagtc tggcctgatg cttctgtgct cggtgctcct gggtagcaag 841 gcgcttctgt gaccctgggg gagctgggtg cttgagcccc aggcccctct ggcctcctct 901 cagggccact gtcagtgagg gagccctggc caccagcact caggtcctgt accctcttgt 961 tcaggtcatt gcgctctgtc tgcagtgccc ggcacagctt ctccagccgt tggattttta 1021 cctgcaggcc ctccagttct ttatcccgga ctgttttctc ctcagccatc tcaagcaggg 1081 ccttgttgct gctctcccac cgggaccggt acatggtggt ttctttctcc agcttcttga 1141 tcttcttagt catcttttcc atctcctgct tgaatgtggt gaatacctcg ctgcttttgg 1201 aaagtgtgtt ctggaactcc tcaaacttct ctgtgtatag ggcaagctgt tgcttcaggt 1261 gggtctcttg ctgcttcatc agctcacaca tcctctggga ctctactgcc tctttcagga 1321 gaaaatcctt ctcccgctgg tgccgctctt ctgcctcctt tagcatctcc tgggcctgct 1381 ggagcttggc atccaccagc tgctgttgta ggtccttgtg tttgaagact ttgtcgatat 1441 gctcctcgcg cagctcatac tgctcaatca gcttcttgag cctctcagcc agctccatgt WO 00/09525 PCTIUS99/17712 EPI-109 1260 1501 tctcttggcg cagcttggag ttgcgctcat tgtgctgttc catctgcagc tgaatgtcat 1561 tcagtgtcac ctggaagtgc gaggtcacct ccttgcgctt ctcctcctcc tcccgggccc 1621 gctgcacacc ttcttccttg agggagcggt tgtgcccgtg cagctcacgg cataggctct 1681 caagcttgct gcgggccagg acggcttgct gtgctcaccg cgcaggtggt ccttctcttg 1741 caccagctgg ctctgctttt tctgtaggag cttcatctgc ttctgtgaat tcc (2) INFORMATION FOR SEQ ID NO:93: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1248 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:93: 1 aaatcctggc tgtcatgtac ttgctatggg cctagagtag cttacctaaa tgctactaac 61 cttcctccat accattattg taaagattaa aggtgatgca tctgttaagt aactaataga 121 gtgcttatta aaaggtaggt gttcaataag tattaattcc ctccctttct ttttcttact 181 agtgcacttg tgtttttaat ggatcatact ttaccctaga ttgtattgta ggaggcatcg 241 tggatggatg gctgctggaa accccttgcc atagccagct cttcttcaat acttaaggat 301 ttaccgtggc tttgagtaat gagaatttcg aaaccacatt tgagaagtat ttccatccag 361 tgctacttgt gtttacttct aaacagtcat tttctaactg aagctggcat tcatgtcttc 421 attttgggat gcagctaata tacccagttg gcccaaagca cctaacctat agttatataa 481 tctgactctc agttcagttt tactctacta atgccttcat ggtattggga accatagatt 541 tgtgcagctg tttcagtgca gggcttccta aaacagaagc caactgggtg aatgtaataa 601 gtgatttgaa aaaaattgaa gatcttattc aatctatgca tattgatgct actttatata 661 cggaaagtga tgttcacccc agttgcaaag taacagcaat gaagtgcttt ctcttggagt 721 tacaagttat ttcacttgag tccggagatg caagtattca tgatacagta gaaaatctga 781 tcatcctagc aaacaacagt ttgtcttcta atgggaatgt aacagaatct ggatgcaaag 841 aatgtgagga actggagaaa aaaaatatta aagaattttt gcagagtttt gtacatattg 901 tccaaatgtt catcaacact tcttgattgc aattgattct ttttaaagtg tttctgttat 961 taacaaacat cactctgctg cttagacata acaaaacact cggcatttca aatgtgctgt 1021 caaaacaagt ttttctgtca agaagatgat cagaccttgg atcagatgaa ctcttagaaa 1081 tgaaggcaga aaaatgtcat tgagtaatat agtgactatg aacttctctc agacttactt 1141 tactcatttt tttaatttat tattgaaatt gtacatattt gtggaataat gtaaaatgtt 1201 gaataaaaat atgtacaagt gttgtttttt aaaaaaaaaa aaaaaaaa (2) INFORMATION FOR SEQ ID NO:94: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1202 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:94: 1 tgtccggcgc cccccgggag ggaactgggt ggccgcaccc tcccggctgc ggtggctgtc 61 gccccccacc ctgcagccag gactcgatgg agaatccatt ccaatatatg gccatgtggc 121 tctttggagc aatgttccat catgttccat gctgctgctg acgtcacatg gagcacagaa 181 atcaatgtta gcagatagcc agcccataca agatcgtatt gtattgtagg aggcatcgtg 241 gatggatggc tgctggaaac cccttgccat agccagctct tcttcaatac ttaaggattt 301 accgtggctt tgagtaatga gaatttcgaa accacatttg agaagtattt ccatccagtg 361 ctacttgtgt ttacttctaa acagtcattt tctaactgaa gctggcattc atgtcttcat 421 tttgggctgt ttcagtgcag ggcttcctaa aacagaagcc aactgggtga atgtaataag 481 tgatttgaaa aaaattgaag atcttattca atctatgcat attgatgcta ctttatatac 541 ggaaagtgat gttcacccca gttgcaaagt aacagcaatg aagtgctttc tcttggagtt 601 acaagttatt tcacttgagt ccggagatgc aagtattcat gatacagtag aaaatctgat 661 catcctagca aacaacagtt tgtcttctaa tgggaatgta acagaatctg gatgcaaaga 721 atgtgaggaa ctggaggaaa aaaatattaa agaatttttg cagagttttg tacatattgt 781 ccaaatgttc atcaacactt cttgattgca attgattctt tttaaagtgt ttctgttatt 841 aacaaacatc actctgctgc ttagacataa caaaacactc ggcatttaaa atgtgctgtc 901 aaaacaagtt tttctgtcaa gaagatgatc agaccttgga tcagatgaac tcttagaaat 961 gaaggcagaa aaatgtcatt gagtaatata gtgactatga acttctctca gacttacttt 1021 actcattttt ttaatttatt attgaaattg tacatatttg tggaataatg taaaatgttg 1081 aataaaaata tgtacaagtg ttgtttttta agttgcactg atattttacc tcttattgca 1141 aaatagcatt tgtttaaggg tgatagtcaa attatgtatt ggtggggctg ggtaccaatg 1201 ct (2) INFORMATION FOR SEQ ID NO:95: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14928 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:95: 1 ggcattgtaa tcagacagaa ctggcctcaa atcctggctg tcatgtactt gctatgggcc 61 tagagtagct tacctaaatg ctactaacct tcctccatac cattattgta aagattaaag 121 gtgatgcatc tgttaagtaa ctaatagagt gcttattaaa aggtaggtgt tcaataagta WO 00/09525 PCTIUS99/17712 EPI-109 1261 181 ttaattccct ttctttcttt ttcttactag tgcacttgtg tttttaatgg atcatacttt 241 accctagatt gtattgtagg aggcatcgtg gatggatggc tgctggaaac cccttgccat 301 agccagctct tcttcaatac ttaaggattt accgtggctt tgagtaatga gaatttccgg 361 taagaagaaa aatagatgaa aatatcctat ggaatttccc ttaaaggtcg tctgaatctc 421 agagtcittg caataagtta catggttatt ctccaaagat cttgagatat cacagatgtc 481 tgttcacatt tggattgttc ttattttgaa aataaatagg tttttaaaaa ctctattgac 541 catcttgata ggctcttctt gtcattataa atgtgttatt tcacttatcc cactcttttg 601 tgttctctaa atqtctttgt actcactaaa ttgtgtagtc ttagagggca gggtgtgggt 661 atcattcatc tttttgaaag gaagcatgaa caattagtgg ttaaggtggc agttaacact 721 gctttctgaa actttaaaag cttcgacaac acaaaagagg caggtgaaag taccaaaact 781 ctggtaagtt gtaggataaa tgattttcct aaatcaccaa gaaagattat tagtcactct 841 caagatggaa tacagtatct gtaattggtt ccattttatc caatttttca ccaaataata 901 ttaatataat tcattttcat aatttacatg aagttaatat aactattgca tctctgttag 961 taatgcatgt tattaacctg tgctgtataa aatattttga cctattaaaa aagaaagaag 1021 gatgaggagg aggtcaaaga taatataaaa actttaagtg gtgacattgg tatgtatgta 1081 aattaacaaa tatgtcaact ttgttaaatt atctttgaca tgcatctgca gaaatatctg 1141 ttaaggaact ttgtgcataa gagacagagt tggaggtggg agagaaagtg aaaaaagata 1201 aattatagtt ttattatttt tgataagggg cagtaattat gaaattatga caaacttaca 1261 tctttagacc tagaaatatg ttgacatgtt attttaaacc tcacttttta actaaaaaat 1321 ttaaccattt gtctatgatt atatttttca gaaaccacat ttgagaagta tttccatcca 1381 gtgctacttg tgtttacttc taaacagtca ttttctaact gaagctggca ttcatgtctt 1441 cattttgggg gtaattttat ctttaggcat aaataacatt atgttcatgg tcatgatgat 1501 tgtccttgga tatattttcc attaaattag tttacgttca gtttgcttat atctctaggt 1561 actcagtatc tgggggatag aaggcagact acagagattt agagaggttt ggtaaacacc 1621 taactgagca tttttctaca ttgtggtaat agtccaaaca agcattatag ccctcaaata 1681 aattgggcct tttgatattt aactgaactt ggaagtatac cacttattga tagactacat 1741 atttttcatg gcaattaaaa gtagatattt agaatttgct tatgttactt ttttatctgt 1801 ccctgacact gactcctcct atcccttgat ctttatccta gttcagttta aaacatttct 1861 ttctttattt aagccttttg ttgtttcctt ctaataaaat tcatatgttt ccatgactat 1921 taactttttt cttctctctt agatgcagct aatataccca gttggcccaa agcacctaac 1981 ctatagttat ataatctgac tctcagttca gttttactct actaatgcct tcatggtatt 2041 gggaaccata gatttgtgca ggtaattctt catcataaga cagattagtg ttgactatca 2101 tgcttctgtg taagatccat caggaagtga gtgattattt ttcctcaagc tctaagcatc 2161 attccaatgt tacttggtca gtataagtgt attttgtctg gatattaaat tttaattttt 2221 atgaaatttg tgaaagtgag taagtatatg atcattcagc ctacactgga atgaagtctg 2281 tactgtttat ggagaaagct gctgcaagca tagtaagagt gtgagcaaca tgaaaggggc 2341 atgtttaatg tagtgtaaaa aaaatttact atcaaaatca ttacatgaaa atgattatta 2401 ctcattttaa gaattttacc tatttattag acttcaaagt ctctgtaaat ctctacttaa 2461 aggaaactag taattcattc aaaatcattt attgagcatt gccacacatc tggcactgct 2521 tctatttcat tgtgataaat tgagccagtt tatttataaa gtatgcctac agttaggctt 2581 ttctctaatc cgggttggtg aagcctcaag ttatcataaa atgccaaaat tgtactatat 2641 gctcaatgtt tatgttcagt tacaaggctg ttgaatgcac agaagcaagg ataacactga 2701 ttttttcact ggtcagaata aaaattattg attgctcttt tgcttatagt attcatcaag 2761 atgaataggc tccttcaaaa tgctttgctc tatggttttt ctttcagctg tttcagtgca 2821 gggcttccta aaacagaagc caactgggtg aatgtaataa gtgatttgaa aaaaattgaa 2881 gatcttattc aagtgagtac tcatttttcc ataaaatgcc tggtataact gctatggagt 2941 ttgtctctct ctgtgttttt ctgtctgtct taaggaaacc acacttgaaa caataatatt 3001 tttgtagaaa tttatgatct tataaagctc aaaaagaagt cttttcctta ctgttttaga 3061 atctaattat ctttaaaacg taatttataa gcggcccaga cggatgagtt ctagtctgca 3121 caggtgaggt attctcttcc tctatctgga gaagccagat atcttggtgg cacctgcagg 3181 gagaatggct tgacccaggg aacagctgtt gttgcttgtg gactaaaggc cctcttctcc 3241 cacctcaaga aaacaggtgg cctgacctaa ggaagtgatt tttgccatag caggtaatac 3301 cagcttcagt ggaagtctcg atggcaccaa gcataccaaa atagcaccac aaagttctga 3361 aaactaaatt gtcattggaa tcacagcatt aaaaaatagg ttagaacttg catgctaaat 3421 ccaaacaacc tgactgcatg ttaaaataga agatttaaat aggaccagag tgtcctaaca 3481 taatagacat gaagccaaga tacaattgga aatcacccat tgtaacaaga aataggaaag 3541 ttacaactta aatgagaaaa tatagtcaac agattacaaa attgaagtgg atcagatgtt 3601 ggaattctct gacatagatt tgaaagcaga cattataaaa agtgcttgaa aaagcaatta 3661 caaatgccct tgaagcaaat gaaaaactaa atgccttaac aaagaaatag aagatatgaa 3721 aggaaccata tagaaattat ataactgaaa atataactga aatataaagc aaactgtaaa 3781 ggctcattag cagaatgaat gacagaggaa tgatagttaa tttgacaaca gaatactaga 3841 gagacagttg acttaagaaa aaaaaagcat cactgatctt gacgacagta acaaaagatt 3901 cagcattcct atggttagta tcacaggaga gtatgagaat acaccaagta aaagagagag 3961 attggttgaa ttcataacaa aacaccaccc atctatacta tctataagca gttcacttct 4021 agtacaatga catacatagg ttgaaattta aaaagacaga aaaagatata gcatactata 4081 atgggttgaa tagtgtcccc ccaaatttca catcctcttg gaaccttaaa atgtgatctt 4141 attttgaaat aatatctttg caaatataat taatgaaatt aagatgagat catactagag 4201 tagggggggc cctaaatcca atgacaagtg tctttattag aaaaggaaag gacacagagt 4261 aactcactgg gaagaaagcc atgtgaagac agaggaagag atcagagtga tgcggctata 4321 agccaaggaa ggccagagat tgccaggatc caccagaacc ttggggaagt caagaaagca 4381 ttcttctcta gactgataca catgcataca ttaattataa aaagcagaag tggctatatt 4441 aacatcaaag ttaatgttat taacataaag tagacttcac agaaaataaa gttgctataa 4501 tccagaggga tattacaaaa tgataaaaaa taaatctgtg aggaaaacat aatgttctta 4561 aatgtataca catcaaacaa cgaagactca aaatttgtga aacaaaaaat aatagggata 4621 aaagagaaat agacaaatcc acaattattc ttgaggactt cactgcctcc tcctcagtaa WO 00/09525 1262 PCTUS99/17712 4681 ctaatggaag tactagacag aaaatcagaa agggcataaa aatacaatat aaccaaccaa 4741 caggatctaa tttaatacat agagcactaC acccaacaac agcagaatat actttctttt 4801 atcaagacta aatatatact gagccataaa agaaacttta aaaatttttt cagaacttaa 4861 atcatgcaga atttgttctc aaaccacaat ggaatcaaac cagaaatcaa gaaattaaat 4921 acaacgggca aatctccaaa tgcttggaaa ttaaatacta tacctctata taatccatgg 4981 gtcaaagagt aaatctcaaa ggatattcat aatacataga atgaaaaaaa atgaaataca 5041 gcatatcaag atatatgtga tgtggctaaa gcaatactga caggacattt tttaaaatca 5101 aatgaataca ttagaaaaaa aggagaatta tcaaatcaaa aatctaagtt actgcttcaa 5161 gaaactagaa gaagtagagc aaaacaaatt caatacaagc agaacaaaga aaatatttaa 5221 atataagagc caaaattaat gaagttgaaa tcaagaaaac aatagaaaaa attaatgaaa 5281 cataaaactg gttatttgga aaatcaatac aattgatctt taattgacag aaataagaga 5341 gaagacacaa atctcaggaa tgaaatttgg ggctgtcact acagaatctg cagtcattag 5401 aaggataata agaaaaacta tgaacaattt tatgctcaca aatctgataa cttagaggaa 5461 atggaccaat tcttcagaaa ccacaaacta ccaaaacata atgaagatga aatagacaat 5521 ccaaacactc atataatcac taaatacatt gaattcatca tacacaagct cccaaaaagg 5581 gaccttcaag cctgctggtt acactgaatc attctatcaa atatttacag aagcattaac 5641 aacaattgta cagtctcttc tagaaaatag aagaggaagg aacattttcc agttgatttt 5701 aggaggccag tattactgtg atgctaaaac caaataaaga tattactaaa aaagacaact 5761 acaaaaatat ctcccattaa cttagatatt aaaatgctct ataaaatatt aacaaatcga 5821 attcagcaat gtataaaaag aattatacac catgaccgag tgagatttat ttcaggtaca 5881 caagtcttgc tcaattattt gaaagtcaag caatgtaatc taccctatca acaggctaaa 5941 gaagaaaatc atatgtagaa aaggtatctg ataaaatgca acacctctca tggcctgtgt 6001 ccctccctat gcctcctgga tttatatgtt gaagtactaa ttgccagtat atcaaaatgt 6061 gactgtattt tgagataggg tcagttaaaa tgaggtcatg agggcaggtc ctactgcaat 6121 atgactggta tctttagaaa aacagataag ggtatagata cacagagata gaaaaccatg 6181 tgaagacact gggagaaaat ggccacctat aagccaagga gggaggactc caaagaaacc 6241 aacactgctg gtaccctgat ttcagacctc tagcctcctg aattgtgaga aaataaagtt 6301 ctattattta agtcaccaag tctgtggtac tttttatagc agccctagca gactgatata 6361 aacacctatt gaagataaaa tttcttagaa agtaggtgtg gagaactgcc tcaacttggt 6421 acaaaacatg ttcaaaaagt ctagagctac catacttaat ggtgagtaca agactgaatg 6481 tttttctgct aggactggaa actaagcagg gatatcttct ctcaccactt ttactcaaca 6541 taattgtctg agttttctgt tgcttataac agagtacttg aaatgcataa tttataaaga 6601 aaggaattta tgtcttatgg ttatgagact gaaaagttca aggttgagga gccacatctg 6661 gtgagggcct tcctgctggt gggggctctc tggagtccag aggtgacaaa aagcatcaca 6721 tggcgagggg ctgaatgtac tcatgtgcta gctcaggtct ctcttcctct tcttataaaa 6781 ctaccggttc cctttccgta ataacacatt gatactctaa tccattcatg agggcagagc 6841 cattgtgatc caattacctc ttaaagcccc acctctcaat actgccacat tggggattaa 6901 gtttcaatct gaattttgga ggggacattc aaaccacagc aataatattg gaagtttagc 6961 caaattatga agcaggagag aaaaaatgta tgagaaaaaa ataaataaaa ggcacacaga 7021 ttggaaagga aaattataca tcaccccaag ttttttggag agaaagtagt aaaaatgggt 7081 atattttgtt tagaaagtaa tgcaaattaa aaccacaatg acatattatt acatgcagct 7141 ataagcgtat acagaataaa aaatagtgat gatgctaagt aaatataaat gaacaagggt 7201 gataatgctg gcaaggatgt ggagaaactg gatcattcat acattgctgg tgatgatgta 7261 aaatgataca ggcactgtat aaaatagttt ggcagcatcc tatgaaacaa aacatgcatt 7321 tgccttacaa tccaacaatt gtgctcttag acattcatcc ttgataaatg aaaactacgt 7381 gcacacaaaa atatgtacat gaatgttcac agagattttt tcatgactgc caaaaactgg 7441 aaacagatgt gcttcagttg gtaaaatctg tgatatatca tgtcagggaa tactacagag 7501 caataaaaag gaacaaacta gtgataccca caagttaggt ggatctccag ggtattatga 7561 tgagtgaaaa aagccagtct tcataaagaa actgtggtac atttataaaa tagaatatta 7621 tccagtgata aaaagaaata agctatcaag ccatgaaaag aaatggagaa accttcaaag 7681 tcatattgtt gagtgaaaga tggggacgcc aatctgaaaa ggcttcacac tgtatgatcc 7741 caactatgac attttgaaaa aggcaaagct atggagacaa taaaaagatc agtggttgtt 7801 aggggtttgg agggaaggag aaatggctag gcagagcaca ggctactttt aaagcagtga 7861 aaatattaat atatgatgat gggtggcatt atacatttgt caaaacctgt aaaacataca 7921 acacaaataa tgagccctaa tattctgtac acttaagatc ataatagtga ttcaccaact 7981 ataacaaaca caccacacta atgcaagata ttaacaatag ggaaactggg gtggagaaca 8041 aaggggtgta taagtctctg tactttctgc tagtttttct gtaaacctaa atggctcata 8101 aaaatgtcta tcaattcttt taaaagctaa tttcagaagg ttacatatga tatgagtccg 8161 tttacataat attcttgaaa tgacaaaatt ataggcatgg agagcagaga agtggttgcc 8221 agaatttaga gagattgggt gatgatgagg tatgtatggg gagaaaggtg actttggtta 8281 tgaaagaata gcagcagaat ccttgtggtg atgaaactat tttgtgtctt aactgtggtg 8341 gtggtgatgt gaatctatgc aaatgataaa attgcataaa acttcacaca tatgcaagca 8401 cacacactgt ggcacataaa acttgtgaaa tctgaacaag gtgagtgcat tgtattaatg 8461 tcaattttct gattgtaata ctgtactgtg gttatggaag acattaccac tgggagaagc 8521 ttgttgaagg gtacacagga tctctctgta tttactctta cagtttcata tgaattttaa 8581 attatctcaa aataaaaaaa gaattaaaaa caatttaatg ttttcagtag gttgttctca 8641 taatatttaa agcagggcat agtttttaat attgtctaat tttgtttcct ttcagtctat 8701 gcatattgat gctactttat atacggaaag tgatgttcac gtgagtatac tttttttcaa 8761 aattgctatt tgtcttgtta ttaaagtttt taaaagtata tttttgtaac aactaaaata 8821 tggtagtttt aaaatctaac ttttggtgtg tttctataat atatggtcca tgagttttat 8881 tagtgattat tgagatggga cttggggaca gatagctaca tcaatgctat ttttgtaatg 8941 gtgccaaacc aaaatattaa aagagtcttt tccatcaatg tcaaacaaga tacattatac 9001 cttttgtga tgcagttca tcatggtgca attagatgca aaaatcagat taactgtttc 9061 aatttaaag taaccaatat atcagttatt tccaatgctg taatgtatca ccatctgcaa 9121 tcatattt c cataaattac ttaaaatcat tcatgttctg cattttacat gattctctac WO 00/09525 1263 PCT/US99/17712 9181 atttgtcaga aaaagattct aattattctc tatgtgagaa aggaaacata acccatgaaa 9241 cttattaqaa ctgaaaaatg gtcttgaact tgtttcatta ataccctgac atttcctaag 9301 gaatgtagga tttgtcatgt tggtggtggt tcttcccttc agtattgtta ctaaaaccaa 9361 gaaatgaatc cccaacttca cgtcagggaa aacaaactct atgtcctctc tccattattc 9421 ctcaattaga acttctctta catagatgac tttctaagca ttggaaagaa accatagtca 9481 gaaactagaa aaaagagata ttcactaacc aattgggtca tgctgctgca caaagaaatt 9541 gtctccctcc tctggcttca gcatggattc tgtttttctt tgcatttttt gtaaaatgga 9601 aagtagtcaa ttagccacca aattcagcat cctgaaattg cttttttgca agaagataac 9661 tttgcaaccc atgggttaga gaaacaacct tagattttag attttagatt ttagaagttt 9721 agattttaaa actgactcca ccacttttta cttgtgttac cttggagatt gctaaacatt 9781 tctgaagctc atttttatta ttgctgatat ggtgacagta tttgtctttc aatcctaagc 9841 agtgactgtt gggtttaagg aatattacca gtgctgggca catgggtgta ttccttcatt 9901 ttttttatcc attcagtaag catttgtgaa gtgtctgcag gctcccaggt actgtgcaag 9961 gtatcgagga cacaaagtca aataatggtc aaatccctag atattccttg tttcctttct 10021 ttaagttatt gttaaagtaa atgttgtgga aaacatattt ttgtggcacc taagagagcc 10081 ttttctgatt tgatctgcct gtaagtggac actagtcctg ctttgatttt tctaataaat 10141 ttcttggaat tacttctctc cctctggaac tttggaactt gaaagaacag tataattagc 10201 agctaccact atttaaaatg ttaacaacac aatttgattc taaaaattct tacaaataaa 10261 ctgtctatat tgatgttttc agactctaag gccagtatta tiaccctttc cacaggggaa 10321 atgtgctcgg tgagaaaaac tggccactat ttctgcattt tctagtttca tgttcttctg 10381 tacaatattg ccatccttct tgattgtgtt ttgttggttt gttttggttt ttattttaaa 10441 gccaaaagaa aaaaaattaa gctgcctcct atgtaaaatt tcttaaggat attgtgtatc 10501 tttataaaat atttggattg actttttgaa aatcaaaatt acatcagtat gaaaattaat 10561 aatcagaaaa aagtaattgt tctttataac ttttattttt agcccagttg caaagtaaca 10621 gcaatgaagt gctttctctt ggagttacaa gttatttcac ttgagtccgg agatgcaagt 10681 attcatgata cagtagaaaa tctgatcatc ctagcaaaca acagtttgtc ttctaatggg 10741 gtgagttttc caacagttgc ttagagttgc atcttatgtt ttgggcctga tttggagaag 10801 tcattcatgg acaagcagat cctcctaagg ggcaatcagg agaaggagtc ctgttccagt 10861 ggagtggtgt gcaaaagtgg caccatctcc agcatgcaca caatgctaaa ctgttcaatg 10921 attgattcag tagacaaaca tttacagaat aatgccaggt agtgtgcttc agtgctagaa 10981 ttatagttgc aaaccagaca gacaggtcac tgacctcaag gtgtttattg tcaggtgcag 11041 tggatagaca ttaatctaat tacatactca aatgtctaac atcaataata gtaactcaca 11101 tttattgagt tattactgta tgccagacac tattctttga gctttaaatt gataattcat 11161 ttaatcctca tgataaatct gtgagatagt tatctttatt tctgtttgaa tgttgaagaa 11221 attgtagcac tgagagcctg gatcactcgc ttcagttcat acagctagta aaatggggag 11281 ccacaactct tacccgagca gtctgtctgc agagtctgtt atctcatgag aagataaatg 11341 ctttaaaaag ataacaatga aaatattaat gattcgagta taatctggga catcccaggc 11401 aacttgagca gtagagggtt ccaggagagc aaattctagg tactcgtatg ataggctggg 11461 gaatcagctg tgcaatggcc ctgaagtgca aagaattagg gctttcatgg caaaacacca 11521 gtggccaaag caaggtagag agaaaqcagt tttgcaacaa agaggcataa tcaaattagt 11581 tcatttcata aatacttttt agccctcagg agacagtatg aaaaaatacc cataatccct 11641 gctgttaaag agggaggaaa cagaaataaa ccaagcactc agcaaatgag taataagtta 11701 gttatttatg aagtccagtg gtgaaaaagg acacagggta ggggcactgg ggctccagtt 11761 agggtaggct gagctaataa gctgccattt gacaaagatg tgagagaatg agccttaagg 11821 atatctaggg acatatgttt aggcagagac aactgaaagt gcaaaggccc taagcttgtg 11881 tgggtggaca ccttgacttt tctctaaaaa tacaagactg ctttaggtct ttgcttcagt 11941 gtcaccttct cagtgattta cctatttaca gttgcaatcc cttccctatc tgagcactcc 12001 ctgtcccctt ctctgcgtgt cccatatctg gaatatgata tattttatgt aatgggtatt 12061 gtctgttttt ccctactaga atgtcagctt aaaatggaca agtgtttttg ttttttatta 12121 gtactatatc caaattccca gaacagtgtc tcatatatat taaatacttt acatatgtat 12181 gaaatgaatt tattaaggtt tataatactc ttatgatgtt atctccatct tattggtgga 12241 aagagtgagc cacgcaacag gtaactcatg gcaaaataaa tgatgagctc tttaatgtga 12301 atgttgatag tcatcctcat catgacagag tgtgacatac gtgctggaat gcgtgggcag 12361 gactgcacag tcagaagacc tggatgggaa gaatttcagt tgattatgtc agttgagatg 12421 agtcaatatc tctgtcttcc tatctgacat gattattttc aggatcaaat aggacagcat 12481 tatatgaaat atgacagtgc ttggcataga ggatgtgctt gataaatgtc gctgattctg 12541 aattccaaat agttaatgga tataaaatct aatttttatt tttgctggca cagccttcat 12601 ggttcagatg atctctaaaa agtttattct taattgctac atttggaaca ttctagttat 12661 ccatgagact gtgtttgaag tacaacaatt tgtggtattc acctaaatgg ctcagttcaa 12721 ccaatgggtg attacagtgt gtcaggccct gtgctaaatg ctagggaaac aaacatactg 12781 gctctgacct tctggcagag agcttagaga atagtattac agtataaaaa gagtaaaact 12841 tcataatatg aatagaatac atgacatatt gtgagagagg tctaaataag gggttctgag 12901 atgtaaagat gggacattga gtccagccct aggagcccag gggttcagag aagcctccct 12961 aaaagagtac ctgaataatc ttaagtgcga gtagcagcag ctaaaatagg aatgaatgta 13021 acagagagaa aagcaaaggc agagaggcat ctaatagtat gctgtgcatg gcaaggaaag 13081 ccagatgctc actcagtgtt tctagggcat aacattgagg caagggggat atgtgaaata 13141 aataggtaag gaacagctca tgaagagcct gtgtgctatg cagggaggca tggtctttat 13201 gctagaagca gatgatagga aaccattgaa gggctcaaag caggaactcc gtggtctgat 13261 agacacagct tatttttctc aatgtcctta acccattatt ggaaaaataa acatatatca 13321 aatctccctg ttctctttcc tcgtagttct tcctaatatg ctatttattt gctaaagctt 13381 tcatatctca agacctcacc atatggttca aacgatatga tattcccatt cccatgaatg 13441 tatatttaat ttaattataa attgccaatt taatctctct ciatattttg cagaatgtaa 13501 cagaatctgg atgcaaagaa tgtgaggaac tggaggaaaa aaatattaaa gaatttttgc 13561 agagttttgt acatattgtc caaatgttca tcaacacttc ttgattacaa ttgattcttt 13621 ttaaagtgtt tctgttatta acaaacatca ctctgctgct tagacataac aaaacactcg WO 00/09525 1264 PCT/US99/17712 13681 gcatttcaaa tgtgctgtca aaacaagttt ttctgtcaag aagatgatca gaccttggat 13741 cagatgaact cttagaaatg aaggcagaaa aatgtcattg agtaatatag tgactatgaa 13801 cttctctcag acttacttta ctcatttttt taatttatta ttgaaattgt acatatttgt 13861 ggaataatgt aaaatgttga ataaaaatat gtacaagtgt tgttttttaa gttgcactga 13921 tattttacct cttattgcaa aatagcattt gtttaagggt gatagtcaaa ttatgtattg 13981 gtggggctgg gtaccaatgc tgcaggtcaa cagctatgct ggtaggctcc tgccagtgtg 14041 gaaccactga ctactggctc tcattgactt cctactaag catagcaaac agaggaagaa 14101 tttgttatca gtaagaaaaa gaagaactat atgtgaatcc tcttctttat actgtaattt 14161 agttattgat gtataaagca actgttatga aataaagaaa ttgcaataac tggcatataa 14221 tgtccatcag taaatcttgg tggtggtggc aataataaac ttctactgat aggtagaatg 14281 gtgtgcaagc ttgtccaatc acggattgca ggccacatgc ggcccaggac aactttgaat 14341 gtggcccaac acaaattcat aaactttcat acatctcgtt tttagctcat cagctatcat 14401 tagcggtagt gtatttaaag tgtggcccaa gacaattctt cttattccaa tgtggcccag 14461 ggaaatcaaa agattggatg cccctggtat agaaaactaa tagtgacagt gttcatattt 14521 catgctttcc caaatacagg tattttattt tcacattctt tttgccatgt ttatataata 14581 ataaagaaaa accctgttga tttgttggag ccattgttat ctgacagaaa ataattgttt 14641 atattttttg cactacactg tctaaaatta gcaagctctc ttctaatgga actgtaagaa 14701 agatgaaata tttttgtttt attaaaatt tatttcacct taattctggt aatactcact 14761 gagtgactgt ggggtgggaa atgatctctt aagaatttga tttctttcta ttccatagta 14821 caaactcgtt ctctgttgaa acattcttct atcaccccag tgccctatcc atgtacatgt 14881 gttcttattg ctctagtcaa acggtgctta taaatatctt tcagaaagct taggagaaat 14941 ctatatccta tttgacttcc aataatca (2) INFORMATION FOR SEQ IO NO:96: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 486 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:96: 1 cggattggga tcggacctac ttgattcact tctgggaaat caaggatcta cgtaccatgg 61 attttcaggt gcagattttc agcttcctgc taatcagtgc ctcagtcata atgtctagag 121 ccaactgggt gaatgtaata agtgatttga aaaaaattga agatcttatt caatctatgc 181 atattgatgc tactttatat acggaaagtg atgttcaccc cagttgcaaa gtaacagcaa 241 tgaagtgctt tctcttggag ttacaagtta tttcactga gtccggagat gcaagtattc 301 atgatacagt agaaaatctg atcatcctag caaacaacag tttgtcttct aatgggaatg 361 taacagaatc tggatgcaaa gaatgtgagg aactggagga aaaaaatatt aaagaatttt 421 tgcagagttt tgtacatatt gtccaaaagt tcatcaacac ttcttgattg caattgattc 481 ctcgag (2) INFORMATION FOR SEQ ID NO:97: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 17864 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:97: aaatcctggc agtcatgtac ttgctatggg cctagagtag cttacctaaa tgctactaac 61 cttcctccat accattattg taaagattaa aggtgatgca tctgttaagt aactaataga 121 gtgcttatta aaaggtaggt gttcaataag tattaattcc ctccctttct ttttcttact 181 agtgcacttg tgtttttaat ggatcatact ttaccctaga ttgtattgta ggaggcatcg 241 tggatggatg gctgctggaa accccttgcc atagccagct cttcttcaat acttaaggat 301 ttaccgtggc tttgagtaat gagaatttcg aaaccacatt tgagaagtat ttccatccag 361 tgctacttgt gtttacttct aaacagtcat tttctaactg aagctggcat tcatgtctc 421 attttgggat gcagctaata tacccagttg gcccaaagca cctaacctat agttatataa 481 tctgactctc agttcagttt tactctacta atgccttcat ggtattggga accatagatt 541 tgtgcagcgg tttcagtgca gggcttccta aaacagaagc caactgggtg aatgtaataa 601 gtgatttgaa aaaaattgaa gatcttattc aatctatgca tattgatgct actttatata 661 cggaaagtga tgttcacccc agttgcaaag taacagcaat gaagtgcttt ctcttggagt 721 tacaagttat ttcacttgag tccggagatg caagtattca tgatacagta gaaaatctga 781 tcatcctagc aaacaacagt ttgtcttcta atgggaatgt aacagaatct ggatgcaaag 841 aatgtgagga actggagaaa aaaaatatta aagaattttt gcagagtttt gtacatattg 901 tccaaatgtt catcaacact tcttgattgc aattgattct ttttaaagtg tttctgttat 961 taacaaacat cactctgctg cttagacata acaaaacact cggcatttca aatgtgctgt 1021 caaaacaagt ttttctgtca agaagatgat cagaccttgg atcagatgaa ctcttagaaa 1081 tgaaggcaga aaaatgtcat tgagtaatat agtgactatg aacttctctc agacttactt 1141 tactcatttt tttaatttat tattgaaatt gtacatattt gtggaataat gtaaaatgtt 1201 gaataaaaat atgtacaagt gttgtttttt aaaaaaaaaa aaaaaaaa 1 tgtccggcgc cccccgggag ggaactgggt ggccgcaccc tcccggctgc ggtggctgtc 61 gccccccacc ctgcagccag gactcgatgg agaatccatt ccaatatatg gccatgtggc 121 tctttggagc aatgttccat catgttccat gctgctgctg acgtcacatg gagcacagaa 181 atcaatgtta gcagatagcc agcccataca agatcgtatt gtattgtagg aggcatcgtg 241 gatggatggc tgctggaaac cccttgccat aaccagctct tcttcaatac ttaaggattt 301 accgtggctt tgagtaatga gaatttcgaa accacatttg agaagtattt ccatccagtg 361 ctacttgtgt ttacttctaa acagtcattt tctaactgaa gctggcattc atgtcttcat WO 00/09525 1265 PCT/US99/17712 421 tttgggctgt ttcagtgcag ggcttcctaa aacagaagcc aactgggtga atgtaataag 481 tgatttgaaa aaaattgaag atcttattca atctatgcat attgatgcta ctttatatac 541 ggaaagtgat gttcacccca gttgcaaagt aacagcaatg aagtgctttc tcttggagtt 601 acaagttatt tcacttgagt ccggagatgc aagtattcat gatacagtag aaaatctgat 661 catcctagca aacaacagtt tgtcttctaa tgggaatgta acagaatctg gatgcaaaga 721 atgtgaggaa ctggaggaaa aaaatattaa agaatttttg cagagttttg tacatattgt 781 ccaaatgttc atcaacactt cttgattgca attgattctt tttaaagtgt ttctgttatt 841 aacaaacatc actctgctgc ttagacataa caaaacactc ggcatttaaa atgtgctgtc 901 aaaacaagtt tttctgtcaa gaagatgatc agaccttgga tcagatgaac tcttagaaat 961 gaaggcagaa aaatgtcatt gagtaatata gtgactatga acttctctca gacttacttt 1021 actcattttt ttaatttatt attgaaattg tacatatttg tggaataatg taaaatgttg 1081 aataaaaata tgtacaagtg ttgtttttta agttgcactg atattttacc tcttattgca 1141 aaatagcatt tgtttaaggg tgatagtcaa attatgtatt ggtggggctg ggtaccaatg 1201 ct 1 ggcattgtaa tcagacagaa ctggcctcaa atcctggctg tcatgtactt gctatgggcc 61 tagagtagct tacctaaatg ctactaacct tcctccatac cattattgta aagattaaag 121 gtgatgcatc tgttaagtaa ctaatagagt gcttattaaa aggtaggtgt tcaataagta 181 ttaattccct ttctttcttt ttcttactag tgcacttgtg tttttaatgg atcatacttt 241 accctagatt gtattgtagg aggcatcgtg gatggatggc tgctggaaac cccttgccat 301 agccagctct tcttcaatac ttaaggattt accgtggctt tgagtaatga gaatttccgg 361 taagaagaaa aatagatgaa aatatcctat ggaatttccc ttaaaggtcg tctgaatctc 421 agagtctttg caataagtta catggttatt ctccaaagat cttgagatat cacagatgtc 481 tgttcacatt tggattgttc ttattttgaa aataaatagg tttttaaaaa ctctattgac 541 catcttgata ggctcttctt gtcattataa atgtgttatt tcacttatcc cactcttttg 601 tgttctctaa atgtctttgt actcactaaa ttgtgtagtc ttagagggca gggtgtgggt 661 atcattcatc tttttgaaag gaagcatgaa caattagtgg ttaaggtggc agttaacact 721 gctttctgaa actttaaaag cttcgacaac acaaaagagg caggtgaaag taccaaaact 781 ctggtaagtt gtaggataaa tgattttcct aaatcaccaa gaaagattat tagtcactct 841 caagatggaa tacagtatc.t gtaattggtt ccattttatc caatttttca ccaaataata 901 ttaatataat tcattttcat aatttacatg aagttaatat aactattgca tctctgttag 961 taatgcatgt tattaacctg tgctgtataa aatattttga cctattaaaa aagaaagaag 1021 gatgaggagg aggtcaaaga taatataaaa actttaagtg gtgacattgg tatgtatgta 1081 aattaacaaa tatgtcaact ttgttaaatt atctttgaca tgcatctgca gaaatatctg 1141 ttaaggaact ttgtgcataa gagacagagt tggaggtggg agagaaagtg aaaaaagata 1201 aattatagtt ttattatttt tgataagggg cagtaattat gaaattatga caaacttaca 1261 tctttagacc tagaaatatg ttgacatgtt attttaaacc tcacttttta actaaaaaat 1321 ttaaccattt gtctatgatt atatttttca gaaaccacat ttgagaagta tttccatcca 1381 gtgctacttg tgtttacttc taaacagtca ttttctaact gaagctggca ttcatgtctt 1441 cattttgggg gtaattttat ctttaggcat aaataacatt atgttcatgg tcatgatgat 1501 tgtccttgga tatattttcc attaaattag tttacgttca gtttgcttat atctctaggt 1561 actcagtatc tgggggatag aaggcagact acagagattt agagaggttt ggtaaacacc 1621 taactgagca tttttctaca ttgtggtaat agtccaaaca agcattatag ccctcaaata 1681 aattgggcct tttgatattt aactgaactt ggaagtatac cacttattga tagactacat 1741 atttttcatg gcaattaaaa gtagatattt agaatttgct tatgttactt ttttatctgt 1801 ccctgacact gactcctcct atcccttgat ctttatccta gttcagttta aaacatttct 1861 ttctttattt aagccttttg ttgtttcctt ctaataaaat tcatatgttt ccatgactat 1921 taactttttt cttctctctt agatgcagct aatataccca gttggcccaa agcacctaac 1981 ctatagttat ataatctgac tctcagttca gttttactct actaatgcct tcatggtatt 2041 gggaaccata gatttgtgca ggtaattctt catcataaga cagattagtg ttgactatca 2101 tgcttctgtg taagatccat caggaagtga gtgattattt ttcctcaagc tctaagcatc 2161 attccaatgt tacttggtca gtataagtgt attttgtctg gatattaaat tttaattttt 2221 atgaaatttg tgaaagtgag taagtatatg atcattcagc ctacactgga atgaagtctg 2281 tactgtttat ggagaaagct gctgcaagca tagtaagagt gtgagcaaca tgaaaggggc 2341 atgtttaatg tagtgtaaaa aaaatttact atcaaaatca ttacatgaaa atgattatta 2401 ctcattttaa gaattttacc tatttattag acttcaaagt ctctgtaaat ctctacttaa 2461 aggaaactag taattcattc aaaatcattt attgagcatt gccacacatc tggcactgct 2521 tctatttcat tgtgataaat tgagccagtt tatttataaa gtatgcctac agttaggctt 2581 ttctctaatc cgggttggtg aagcctcaag ttatcataaa atgccaaaat tgtactatat 2641 gctcaatgtt tatgttcagt tacaaggctg ttgaatgcac agaagcaagg ataacactga 2701 ttttttcact ggtcagaata aaaattattg attgctcttt tgcttatagt attcatcaag 2761 atgaataggc tccttcaaaa tgctttgctc tatggttttt ctttcagctg tttcagtgca 2821 gggcttccta aaacagaagc caactgggtg aatgtaataa gtgatttgaa aaaaattgaa 2881 gatcttattc aagtgagtac tcatttttcc ataaaatgcc tggtataact gctatggagt 2941 ttgtctctct ctgtgttttt ctgtctgtct taaggaaacc acacttgaaa caataatatt 3001 tttgtagaaa tttatgatct tataaagctc aaaaagaagt cttttcctta ctgttttaga 3061 atctaattat ctttaaaacg taatttataa gcggcccaga cggatgagtt ctagtctgca 3121 caggtgaggt attctcttcc tctatctgga gaagccagat atcttggtgg cacctgcagg 3181 gagaatggct tgacccaggg aacagctgtt gttgcttgtg gactaaaggc cctcttctcc 3241 cacctcaaga aaacaggtgg cctgacctaa ggaagtgatt tttgccatag caggtaatac 3301 cagcttcagt ggaagtctcg atggcaccaa gcataccaaa atagcaccac aaagttctga 3361 aaactaaatt gtcattggaa tcacagcatt aaaaaatagg ttagaacttg catgctaaat 3421 ccaaacaacc tgactgcatg ttaaaataga agatttaaat aggaccagag tgtcctaaca 3481 taatagacat gaagccaaga tacaattgga aatcacccat tgtaacaaga aataggaaag 3541 ttacaactta aatgagaaaa tatagtcaac agattacaaa attgaagtgg atcagatgtt 3601 ggaattcct gacatagatt tgaaagcaga cattataaaa agtgcttgaa aaagcaatta WO 00/09525 1266 PCT/US99/17712 3661 caaatgccct tgaagcaaat gaaaaactaa atgccttaac aaaqaaatag aagatatgaa 3721 aggaaccata tagaaattat ataactgaaa atataactga aatataaagc aaactgtaaa 3781 ggctcattag cagaatgaat gacagaggaa tgatagttaa tttgacaaca gaatactaga 3841 gagacagttg acttaagaaa aaaaaagcat cactgatctt gacgacagta acaaaagatt 3901 cagcattcct atggttagta tcacaggaga gtatgagaat acaccaagta aaagagagag 3961 attggttgaa ttcataacaa aacaccaccc atctatacta tctataagca gttcacttct 4021 agtacaatga catacatagg ttgaaattta aaaagacaga aaaagatata gcatactata 4081 atgggttgaa tagtgtcccc ccaaatttca catcctcttg gaaccttaaa atgtgatctt 4141 attttgaaat aatatctttg caaatataat taatgaaatt aagatgagat catactagag 4201 tagggggggc cctaaatcca atgacaagtg tctttattag aaaaggaaag gacacagagt 4261 aactcactgg gaagaaagcc atgtgaagac agaggaagag atcagagtga tgcggctata 4321 agccaaggaa ggccagagat tgccaggatc caccagaacc ttggggaagt caagaaagca 4381 ttcttctcta gactgataca catgcataca ttaattataa aaagcagaag tggctatatt 4441 aacatcaaag ttaatgttat taacataaag tagacttcac agaaaataaa gttgctataa 4501 tccagaggga tattacaaaa tgataaaaaa taaatctgtg aggaaaacai aatgttctta 4561 aatgtataca catcaaacaa cgaagactca aaatttgtga aacaaaaaat aatagggata 4621 aaagagaaat agacaaatcc acaattattc ttgaggactt cactgcctcc tcctcagtaa 4681 ctaatggaag tactagacag aaaatcagaa agggcataaa aatacaatat aaccaaccaa 4741 caggatctaa tttaatacat agagcactac acccaacaac agcagaatat actttctttt 4801 atcaagacta aatatatact gagccataaa agaaacttta aaaatttttt cagaacttaa 4861 atcatgcaga atttgttctc aaaccacaat ggaatcaaac cagaaatcaa gaaattaaat 4921 acaacgggca aatctccaaa tgcttggaaa ttaaatacta tacctctata taatccatgg 4981 gtcaaagagt aaatctcaaa ggatattcat aatacataga atgaaaaaaa atgaaataca 5041 gcatatcaag atatatgtga tgtggctaaa gcaatactga caggacattt tttaaaatca 5101 aatgaataca ttagaaaaaa aggagaatta tcaaatcaaa aatctaagtt actgcttcaa 5161 gaaactagaa gaagtagagc aaaacaaatt caatacaagc agaacaaaga aaatatttaa 5221 atataagagc caaaattaat gaagttgaaa tcaagaaaac aatagaaaaa attaatgaaa 5281 cataaaactg gttatttgga aaatcaatac aattgatctt taattgacag aaataagaga 5341 gaagacacaa atctcaggaa tgaaatttgg ggctgtcact acagaatctg cagtcattag 5401 aaggataata agaaaaacta tgaacaattt tatgctcaca aatctgataa cttagaggaa 5461 atggaccaat tcttcagaaa ccacaaacta ccaaaacata atgaagatga aatagacaat 5521 ccaaacactc atataatcac taaatacatt gaattcatca tacacaagct cccaaaaagg 5581 gaccttcaag cctgctggtt acactgaatc attctatcaa atatttacag aagcattaac 5641 aacaattgta cagtctcttc tagaaaatag aagaggaagg aacattttcc agttgatttt 5701 aggaggccag tattactgtg atgctaaaac caaataaaga tattactaaa aaagacaact 5761 acaaaaatat ctcccattaa cttagatatt aaaatgctct ataaaatatt aacaaatcga 5821 attcagcaat gtataaaaag aattatacac catgaccgag tgagatttat ttcaggtaca 5881 caagtcttgc tcaattattt gaaagtcaag caatgtaatc taccctatca acaggctaaa 5941 gaagaaaatc atatgtagaa aaggtatctg ataaaatgca acacctctca tggcctgtgt 6001 ccctccctat gcctcctgga tttatatgtt gaagtactaa ttgccagtat atcaaaatgt 6061 gactgtattt tgagataggg tcagttaaaa tgaggtcatg agggcaggtc ctactgcaat 6121 atgactggta tctttagaaa aacagataag ggtatagata cacagagata gaaaaccatg 6181 tgaagacact gggagaaaat ggccacctat aagccaagga gggaggactc caaagaaacc 6241 aacactgctg gtaccctgat ttcagacctc tagcctcctg aattgtgaga aaataaagtt 6301 ctattattta agtcaccaag tctgtggtac tttttatagc agccctagca gactgatata 6361 aacacctatt gaagataaaa tttcttagaa agtaggtgtg gagaactgcc tcaacttggt 6421 acaaaacatg ttcaaaaagt ctagagctac catacttaat ggtgagtaca agactgaatg 6481 tttttctgct aggactggaa actaagcagg gatatcttct ctcaccactt ttactcaaca 6541 taattgtctg agttttctgt tgcttataac agagtacttg aaatgcataa tttataaaga 6601 aaggaattta tgtcttatgg ttatgagact gaaaagttca aggttgagga gccacatctg 6661 gtgagggcct tcctgctggt gggggctctc tggagtccag aggtgacaaa aagcatcaca 6721 tggcgagggg ctgaatgtac tcatgtgcta gctcaggtct ctcttcctct tcttataaaa 6781 ctaccggttc cctttccgta ataacacatt gatactctaa tccattcatg agggcagagc 6841 cattgtgatc caattacctc ttaaagcccc acctctcaat actgccacat tggggattaa 6901 gtttcaatct gaattttgga ggggacattc aaaccacagc aataatattg gaagtttagc 6961 caaattatga agcaggagag aaaaaatgta tgagaaaaaa ataaataaaa ggcacacaga 7021 ttggaaagga aaattataca tcaccccaag ttttttggag agaaagtagt aaaaatgggt 7081 atattttgtt tagaaagtaa tgcaaattaa aaccacaatg acatattatt acatgcagct 7141 ataagcgtat acagaataaa aaatagtgat gatgctaagt aaatataaat gaacaagggt 7201 gataatgctg gcaaggatgt ggagaaactg gatcattcat acattgctgg tgatgatgta 7261 aaatgataca ggcactgtat aaaatagttt ggcagcatcc tatgaaacaa aacatgcatt 7321 tgccttacaa tccaacaatt gtgctcttag acattcatcc ttgataaatg aaaactacgt 7381 gcacacaaaa atatgtacat gaatgttcac agagattttt tcatgactgc caaaaactgg 7441 aaacagatgt gcttcagttg gtaaaatctg tgatatatca tgtcagggaa tactacagag 7501 caataaaaag gaacaaacta gtgataccca caagttaggt ggatctccag ggtattatga 7561 tgagtgaaaa aagccagtct tcataaagaa actgtggtac atttataaaa tagaatatta 7621 tccagtgata aaaagaaata agctatcaag ccatgaaaag aaatggagaa accttcaaag 7681 tcatattgtt gagtgaaaga tggggacgcc aatctgaaaa ggttcatac tgtatgatcc 7741 caactatgac attttgaaaa aggcaaagct atggagacaa taaaaagatc agtggttgtt 7801 aggggtttgg agggaaggag aaatggctag gcagagcaca ggctactttt aaagcagtga 7861 aaatattaat atatgatgat gggtggcatt atacatttgt caaaacctgt aaaacataca 7921 acacaaataa tgagccctaa tattctgtac acttaagatc ataatagtga ttcaccaact 7981 ataacaaaca caccacacta atgcaagata ttaacaatag ggaaactggg gtggagaaca 8041 aaggggtgta aagtctctg tactttctgc tagtttttt gtaaacctaa atggctcata 8101 aaaagtcta tcaattcttt taaaagctaa tttcagaagg ttacatatga tatgagtccg WO 00/09525 1267 PCTIUS99/17712 8161 tttacataat attcttgaaa tgacaaaatt ataggcatgg agagcagaga agtggttgcc 8221 agaatttaga gagattgggt gatgatgagg tatgtatggg gagaaaggtg actttggtta 8281 tgaaagaata gcagcagaat ccttgtggtg atgaaactat tttgtgtctt aactgtggtg 8341 gtggtgatgt gaatctatgc aaatgataaa attgcataaa acttcacaca tatgcaagca 8401 cacacactgt ggcacataaa acttgtgaaa tctgaacaag gtgagtgcat tgtattaatg 8461 tcaattttct gattgtaata ctgtactgtg gttatggaag acattaccac tgggagaagc 8521 ttgttgaagg gtacacagga tctctctgta tttactctta cagtttcata tgaattttaa 8581 attatctcaa aataaaaaaa gaattaaaaa caatttaatg ttttcagtag gttgttctca 8641 taatatttaa agcagggcat agtttttaat attgtctaat tttgtttcct ttcagtctat 8701 gcatattgat gctactttat atacggaaag tgatgttcac gtgagtatac tttttttcaa 8761 aattgctatt tgtcttgtta ttaaagtttt taaaagtata tttttgtaac aactaaaata 8821 tggtagtttt aaaatctaac ttttggtgtg tttctataat atatggtcca tgagttttat 8881 tagtgattat tgagatggga cttggggaca gatagctaca tcaatgctat ttttgtaatg 8941 gtgccaaatc aaaatattaa aagagtcttt tccatcaatg tcaaacaaga tacattatac 9001 gtttttgtga tgcagttgca tcatggtgca attagatgca aaaatcagat taactgtttc 9061 aatttaagag tagccaatat atcagttatt tccaatgctg taatgtatca ccatctgcaa 9121 tcatattttc cataaattgc ttaaaatcat tcatgttctg cattttacat gattctctac 9181 atttgtcaga aaaagattct aattattctc tatgtgagaa aggaaacata acccatgaaa 9241 cttattagaa ctgaaaaatg gtcttgaact tgtttcatta ataccctgac atttcctaag 9301 gaatgtagga tttgtcatgt tggtggtggt tcttcccttc agtattgtta ctaaaaccaa 9361 gaaatgaatc cccaacttca cgtcagggaa aacaaactct atgtcctctc tccattattc 9421 ctcaattaga acttctctta catagatgac tttctaagca ttggaaagaa accatagtca 9481 gaaactagaa aaaagagata ttcactaacc aattgggtca tgctgctgca caaaqaaatt 9541 gtctccctcc tctggcttca gcatggattc tgtttttctt tgcatttttt gtaaaatgga 9601 aagtagtcaa ttagccacca aattcagcat cctgaaattg cttttttgca agaagataac 9661 tttgcaaccc atgggttaga gaaacaacct tagattttag attttagatt ttagaagttt 9721 agattttaaa actgactcca ccacttttta cttgtgttac cttggagatt gctaaacatt 9781 tctgaagctc atttttatta ttgctgatat ggtgacagta tttgtctttc aatcctaagc 9841 agtgactgtt gggtttaagg aatattacca gtgctgggca catgggtgta tccttcatt 9901 ttttttatcc attcagtaag catttgtgaa gtgtctgcag gctcccaggt actgtgcaag 9961 gtatcgagga cacaaagtca aataatggtc aaatccctag atattccttq tttcctttct 10021 ttaagttatt gttaaagtaa atgttgtgga aaacatattt ttgtggcacc taagagagcc 10081 ttttctgatt tgatctgcct gtaagtggac actagtcctg ctttgatttt tctaataaat 10141 ttcttggaat tacttctctc cctctggaac tttggaactt gaaagaacag tataattagc 10201 agctaccact atttaaaatg ttaacaacac aatttgattc taaaaattct tacaaataaa 10261 ctgtctatat tgatgttttc agactctaag gccagtatta ttaccctttc cacaggggaa 10321 atgtgctcgg tgagaaaaac tggccactat ttctgcattt tctagtttca tgttcttctg 10381 tacaatattg ccatccttct tgattgtgtt ttgttggttt gttttggttt ttattttaaa 10441 gccaaaagaa aaaaaattaa gctgcctcct atgtaaaatt tcttaaggat attgtgtatc 10501 tttataaaat atttggattg actttttgaa aatcaaaatt acatcagtat gaaaattaat 10561 aatcagaaaa aagtaattgt tctttataac ttttattttt agcccagttg caaagtaaca 10621 gcaatgaagt gctttctctt ggagttacaa gttatttcac ttgagtccgg agatgcaagt 10681 attcatgata cagtagaaaa tctgatcatc ctagcaaaca acagtttgtc ttctaatggg 10741 gtgagttttc caacagttgc ttagagttgc atcttatgtt ttgggcctga tttggagaag 10801 tcattcatgg acaagcagat cctcctaagg ggcaatcagg agaaggagtc ctgttccagt 10861 ggagtggtgt gcaaaagtgg caccatctcc agcatgcaca caatgctaaa ctgttcaatg 10921 attgattcag tagacaaaca tttacagaat aatgccaggt agtgtgcttc agtgctagaa 10981 ttatagttgc aaaccagaca gacaggtcac tgacctcaag gtgtttattg tcaggtgcag 11041 tggatagaca ttaatctaat tacatactca aatgtctaac atcaataata gtaactcaca 11101 tttattgagt tattactgta tgccagacac tattctttga gctttaaatt gataattcat 11161 ttaatcctca tgataaatct gtgagatagt tatctttatt tctgtttgaa tgttgaagaa 11221 attgtagcac tgagagcctg gatcactcgc ttcagttcat acagctagta aaatggggag 11281 ccacaactct tacccgagca gtctgtctgc agagtctgtt atctcatgag aagataaatg 11341 ctttaaaaag ataacaatga aaatattaat gattcgagta taatctggga catcccaggc 11401 aacttgagca gtagagggtt ccaggagagc aaattctagg tactcgtatg ataggctggg 11461 gaatcagctg tgcaatggcc ctgaagtgca aagaattagg gctttcatgg caaaacacca 11521 gtggccaaag caaggtagag agaaagcagt tttgcaacaa agaggcataa tcaaattagt 11581 tcatttcata aatacttttt agccctcagg agacagtatg aaaaaatac cataatccct 11641 gctgttaaag agggaggaaa cagaaataaa ccaagcactc agcaaatgag taataagtta 11701 gttatttatg aagtccagtg gtgaaaaagg acacagggta ggggcactgg ggctccagtt 11761 agggtaggct gagctaataa gctgccattt gacaaagatg tgagagaatg agccttaagg 11821 gtatctaggg acatatgttt aggcagagac aactgaaagt gcaaaggccc taagcttgtg 11881 tgggtggaca ccttgacttt tctctaaaaa tacaagactg ctttaggtct ttgcttcagt 11941 gtcaccttct cagtgattta cctatttaca gttgcaatcc cttccctatc tgagcactcc 12001 ctgtcccctt ctctgcgtgt cccatatctg gaatatgata tattttatgt aatgggtatt 12061 gtctgttttt ccctactaga atgtcagctt aaaatggaca agtgtttttg ttttttatta 12121 gtactatatc caaattccca gaacagtgtc tcatatatat taaatacttt acatatgtat 12181 gaaatgaatt tattaaggtt tataatactc ttatgatgtt atctccatct tattggtgga 12241 aagagtgagc cacgcaacag gtaactcatg gcaaaataaa tgatgagctc tttaatgtga 12301 atgttgatag tcatcctcat catgacagag tgtgacatac gtactggaat gcgtgggcag 12361 gactgcacag tcagaagacc tggatgggaa gaatttcagt tgattatgtc agttgagatg 12421 agtcaatatc tctgtcttcc tatctgacat gattattttc aggatcaaat aggacagcat 12481 tatatgaaat atgacagtgc ttggcataga ggatgtgctt gataaatgtc gctgattctq 12541 aattccaaat agttaatgga tataaaatct aatttttatt tttgctggca cagccttcat 12601 ggttcagatg atctccaaaa agtttattct taattgctac atttggaaca ttctagttat WO 00/09525 1268 PCT/US99/17712 12661 ccatgagact gtgtttgaag tacaacaatt tgtggtattc acctaaatgg ctcagttcaa 12721 ccaatgggtg attacagtgt gtcaggccct gtgctaaatg ctagggaaac aaacatactg 12781 gctctgacct tctggcagag agottagaga atagtattac agtataaaaa gagtaaaact 12841 tcataatatg aatagaatac atgacatatt gtgagagagg tctaaataag gggttctgag 12901 atgtaaagat gggacattga gtccagccct aggagcccag gggttcagag aagcctccct 12961 aaaagagtac ctgaataatc ttaagtgcga gtagcagcag ctaaaatagg aatgaatgta 13021 acagagagaa aagcaaaggc agagaggcat ctaatagtat gctgtgcatg gcaaggaaag 13081 ccagatgctc actcagtgtt tctagggcat aacattgagg caagggggat atgtgaaata 13141 aataggtaag gaacagctca tgaagagcct gtgtgctatg cagggaggca tggtctttat 13201 gctagaagca gatgatagga aaccattgaa gggctcaaag caggaactcc gtggtctgat 13261 agacacagct tatttttctc aatgtcctta acccattatt ggaaaaataa acatatatca 13321 aatctccctg ttctctttcc tcgtagttct tcctaatatg ctatttattt gctaaagctt 13381 tcatatctca agacctcacc atatggttca aacgatatga tattcccatt cccatgaatg 13441 tatatttaat ttaattataa attgccaatt taatctctct ctatattttg cagaatgtaa 13501 cagaatctgg atgcaaagaa tgtgaggaac tggaggaaaa aaatattaaa gaatttttgc 13561 agagttttgt acatattgtc caaatgttca tcaacacttc ttgattgcaa ttgattcttt 13621 ttaaagtgtt tctgttatta acaaacatca ctctgctgct tagacataac aaaacactcg 13681 gcatttcaaa tgtgctgtca aaacaagttt ttctgtcaag aagatgatca gaccttggat 13741 cagatgaact cttagaaatg aaggcagaaa aatgtcattg agtaatatag tgactatgaa 13801 cttctctcag acttacttta ctcatttttt taatttatta ttgaaattgt acatatttgt 13861 ggaataatgt aaaatgttga ataaaaatat gtacaagtgt tgttttttaa gttgcactga 13921 tattttacct cttattgcaa aatagcattt gtttaagggt gatagtcaaa ttatgtattg 13981 gtggggctgg gtaccaatgc tgcaggtcaa cagctatgct ggtaggctcc tgccagtgtg 14041 gaaccactga ctactggctc tcattgactt ccttactaag catagcaaac agaggaagaa 14101 tttgttatca gtaagaaaaa gaagaactat atgtgaatcc tcttctttat actgtaattt 14161 agttattgat gtataaagca actgttatga aataaagaaa ttgcaataac tggcatataa 14221 tgtccatcaq taaatcttgg tggtggtggc aataataaac ttctactgat aggtagaatg 14281 gtgtgcaagc ttgtccaatc acggattgca ggccacatgc ggcccaggac aactttgaat 14341 gtggcccaac acaaattcat aaactttcat acatctcgtt tttagctcat cagctatcat 14401 tagcggtagt gtatttaaag tgtggcccaa gacaattctt cttattccaa tgtggcccag 14461 ggaaatcaaa agattggatg cccctggtat agaaaactaa tagtgacagt gttcatattt 14521 catgctttcc caaatacagg tattttattt tcacattctt tttgccatgt ttatataata 14581 ataaagaaaa accctgttga tttgttggag ccattgttat ctgacagaaa ataattgttt 14641 atattttttg cactacactg tctaaaatta gcaagctctc ttctaatgga actgtaagaa 14701 agatgaaata tttttgtttt attataaatt tatttcacct taattctggt aatactcact 14761 gagtgactgt ggggtgggaa atgatctctt aagaatttga tttctttcta ttccatagta 14821 caaactcgtt ctctgttgaa acattcttct atcaccccag tgccctatcc atgtacatgt 14881 gttcttattg ctctagtcaa acggtgctta taaatatctt tcagaaagct taggagaaat 14941 ctgtatccta tttgacttcc aataatca 1 cggattggga tcggacctac ttgattcact tctgggaaat caaggatcta cgtaccatgg 61 attttcaggt gcagattttc agcttcctgc taatcagtgc ctcagtcata atgtctagag 121 ccaactgggt gaatgtaata agtgatttga aaaaaattga agatcttatt caatctatgc 181 atattgatgc tactttatat acggaaagtg atgttcaccc cagttgcaaa gtaacagcaa 241 tgaagagctt tctcttggag ttacaagtta tttcacttga gtccggagat gcaagtattc 301 atgatacag agaaaatctg atcatcctag caaacaacag tttgtcttct aatgggaatg 361 taacagaatc tggatgcaaa gaatgtgagg aactggagga aaaaaatatt aaagaatttt 421 tgcagagttt tgtacatatt gtccaaatgt tcatcaacac ttcttgattg caattgattc 481 ctccgag (2) INFORMATION FOP. SEQ ID NO:98: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1610 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:98: cccagagcag cgctcgccac ctccccccgg cctgggcagc gctcgcccgg ggagtccagc 61 ggtgtcctgt ggagctgccg ccatggcccc gcggcgggcg cgcggctgcc ggaccctcgg 121 tctcccggcg ctgctactgc tgctgctgct ccggccgccg gcgacgcggg gcatcacgtg 181 ccctcccccc atgtccgtgg aacacgcaga catctgggtc aagagctaca gcttgtactc 241 cagggagcgg tacatttgta actctggttt caagcgtaaa gccggcacgt ccagcctgac 301 ggagtgcgtg ttgaacaagg ccacgaatgt cgcccactgg acaaccccca gtctcaaatg 361 cattagagac cctgccctgg ttcaccaaag gccagcgcca ccctccacag taacgacggc 421 aggggtgacc ccacagccag agagcctctc cccttctgga aaagagcccg cagcttcatc 481 tcccagctca aacaacacag cggccacaac agcagctatt gtcccgggct cccagctgat 541 gccttcaaaa tcaccttcca caggaaccac agagataagc agtcatgagt cctcccacgg 601 caccccctct cagacaacag ccaagaactg ggaactcaca gcatccgcct cccaccagcc 661 gccaggtgtg tatccacagg gccacagcga caccactgtg gctatctcca cgtccactgt 721 ccgctgtgt gggctgagcg ctgtgtctct cctggcatgc tacctcaagt caaggcaaac 781 tcccccgctg gccagcgttg aaatggaagc catggaggct ctgccggtga cttgggggac 841 cagcagcaga gatgaagact tggaaaactg ctctcaccac ctatgaaact cggggaaacc 901 agcccagcta agtccggagt gaaggagcct ctctgcttta gctaaagacg actgagaaga 961 ggtcgcaagga agcgggctcc aggagcaagc tcaccaggcc tctcagaagt cccagcagga 1021 tctcacggac tgccgggtcg gcgcctcctg cgcgagggag caggttctcc gcattcccat 1081 gggcaccacc tgcctgcctg acgtgccttg gacccagggc ccagcttccc aggagagacc WO 00/09525 1269 PCT/US99/17712 1141 aaaggcttct gagcaggatt tttatttcat tacagtgtga gctgcctgga atacatgtgg 1201 taatgaaata aaaaccctgc cccgaatctt ccgtccctca tcctaacttg cagttcacag 1261 agaaaagtga catacccaaa gctctctgtc aattacaagg cttctcctgg cgtgggagac 1321 gtctacaggg aagacaccag cgtttgggct tctaaccacc ctgtctccag ctgctctgca 1381 cacatggaca gggacctggg aaaggtggga gagatgctga gcccagcgaa tcctctccat 1441 tgaaggattc aggaagaaga aaactcaact cagtgccatt ttacgaatat atgcgtttat 1501 atttatactt ccttgtctat tatatctata cattatatat tatttgtatt ttgacattgt 1561 accttgtata aacaaaataa aacatctatt ttcaatattt ttaaaatgca (2) INFORMATION FOR SEQ ID NO:99: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 393 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:99: 1 atgcctgacc tcaactcctc cactgactct gcagcctcag cctctgcagc cagtgatgtt 61 tctgtagaat ctacagcaga ggccacagtc tgcacggtga cactggagaa gatgtcggca 121 gggctgggct tcagcctgga aggagggaag ggctccctac acggagacaa gcccctcacc 181 attaacagga ttttcaaagg agcagcctca gaacaaagtg agacagtcca gcctggagat 241 gaaatcttgc agctgggtgg cactgccatg cagggcctca cacggtttga agcctggaac 301 atcatcaagg cactgcctga tggacctgtc acgattgtca tcaggagaaa aagcctccag 361 tccaaggaaa ccacagctgc tggagactcc tag (2) INFORMATION FOR SEQ ID NO:100: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 3175 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:100: 1 tgcttaaaaa aacacaacag gattttcgaa gaatcctttc ttagaaaaca aacaaaaaaa 61 ccaaacaaaa acgtactttc tccccactag tttacaccac aggaagcgag agagctgctg 121 ccactgctgc taccacagga agacacagca gggagaagcc ctagtgcctc tgccggctgc 181 ccaggacctg gtatcggccc acagaccaag tcctccacag agggcgagcc agggtggaga 241 agagccagcc cagtgaccca aacatccccg ataaaacacc cactgcttaa gaggcaggct 301 cggatggact atagctttga taccacagcc gaagaccctt gggttaggat ttctgactgc 361 atcaaaaact tatttagccc catcatgagt gagaaccatg gccacatgcc tctacagccc 421 aatgccagcc tgaatgaaga agaagggaca cagggccacc cagatgggac cccaccaaag 481 ctggacaccg ccaatggcac tcccaaagtt tacaagtcag cagacagcag cactgtgaag 541 aaaggtcctc ctgtggctcc caagccagcc tggtttcgcc aaagcttgaa aggtttgagg 601 aatcgtgctt cagagccaag agggctccct gatcctgcct tgtccaccca gccagcacct 661 gcttccaggg agcacctagg atcacacatc cgggcctcct cctcctcctc ctccatcagg 721 cagagaatca gctcctttga aacctttggc tcctctcaac tgcctgacaa aggagcccag 781 agactgagcc tccagccctc ctctggggag gcagcaaaac ctcttgggaa gcatgaggaa 841 ggacggtttt ctggactctt ggggcgaggg gctgcaccca ctcttgtgcc ccagcagcct 901 gagcaagtac tgtcctcggg gtcccctgca gcctccgagg ccagagaccc aggtgtgtct 961 gagtcccctc ccccagggcg gcagcccaat cagaaaactt tcccccctgg cccggacccg 1021 ctcctaaggc tgctgtcaac acaggctgag gaatctcaag gcccagtgct caagatgcct 1081 agccagcgag cacggagctt ccccctgacc aggtcccagt cctgtgagac gaagctactt 1141 gacgaaaaga ccagcaaact ctattctatc agcagccaag tgtcatcggc tgtcatgaaa 1201 tccttgctgt gccttccatc ttctatctcc tgtgcccaga ctccctgcat ccccaaggca 1261 ggggcatctc caacatcatc atccaacgaa gactcagctg caaatggttc tgctgaaaca 1321 tctgccttgg acacggggtt ctcgctcaac ctttcagagc tgagagaata tacagagggt 1381 ctcacggaag ccaaggaaga cgatgatggg gaccacagtt cccttcagtc tggtcagtcc 1441 gttatctccc tgctgagctc agaagaatta aaaaaactca tcgaggaggt gaaggttctg 1501 gatgaagcaa cattaaagca attagacggc atccatgtca ccatcttaca caaggaggaa 1561 ggtgctggtc ttgggttcag cttggcagga ggagcagatc tagaaaacaa ggtgattacg 1621 gttcacagag tgtttccaaa tgggctggcc tcccaggaag ggactattca gaagggcaat 1681 gaggttcttt ccatcaacgg caagtctctc aaggggacca cgcaccatga tgccttggcc 1741 atcctccgcc aagctcgaga gcccaggcaa gctgtgattg tcacaaggaa gctgactcca 1801 gaggccatgc ccgacctcaa ctcctccact gactctgcag cctcagcctc tgcagccagt 1861 gatgtttctg tagaatctac agcagaggcc acagtctgca cggtgacact ggagaagatg 1921 tcggcagggc tgggcttcag cctggaagga gggaagggct ccctacacgg agacaagcct 1981 ctcaccatta acaggatttt caaaggagca gcctcagaac aaagtgagac agtccagcct 2041 ggagatgaaa tcttgcagct gggtggcact gccatgcagg gcctcacacg gtttgaagcc 2101 tggaacatca tcaaggcact gcctgatgga cctgtcacga ttgtcatcag gagaaaaagc 2161 ctccagtcca aggaaaccac agctgctgga gactcctagg caggacatgc tgaagccaaa 2221 gccaataaca cacagctaac acacagctcc cataaccgct gattctcagg gtctctgctg 2281 ccgccccacc cagatggggg aaagcacagg tgggcttccc agtggctgct gcccaggccc 2341 agaccttcta ggacgccacc cagcaaaagg ttgttcctaa aataagggca gagtcacact 2401 ggggcagctg atacaaattg cagactgtgt aaaaagagag cttaatgata atattgtggt 2461 gccacaaata aaatggattt attagaattc catatgacat tcatgcctgg cttcgcaaaa 2521 tgtttcaagt actgtaactg tgtcatgatt cacccccaaa cagtgacatt tatttttctc 2581 atgaatctgc aatgtgggca gagattggaa tgggcagctc atctctgtcc cacttggcat WO 00/09525 1270 PCT/US99/17712 2641 cagctggcgt catgcaaagt catgcaaagg ctgggaccac ctgagatcat tcactcatac 2701 atctggccgt tgatgttggc tgggaactca cctggggctg ctggcctgaa tgcttatagg 2761 tggcctctcc ttgtggcctg ggctcctcac aacatggtgt ctggattccc aggatgagca 2821 tcccaggatc gcaagagcca cgtagaagct gcatcttgtt tatacctttg ccttggaagt 2881 tgcatggcat cacctccacc atactccatc agttagagct gacacaaacc tgcctgggtt 2941 taaggggaga ggaaatattg ctggggtcat ttatgaaaaa tacagtttgt cacatgaaac 3001 atttgcaaaa ttgtttttgg ttggattgga gaagtaatcc tagggaaggg tggtggagcc 3061 agtaaataga ggagtacagg tgaagcacca agctcaaagc gtggacaggt gtgccgacag 3121 aaggaaccag cgtgtatatg agggtatcaa ataaaattgc tactacttac ctacc (2) INFORMATION FOR SEQ ID NO:101: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 3568 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:101: 1 atgcctgacc tcaactcctc cactgactct gcagcctcag cctctgcagc cagtgatgtt 61 tctgtagaat ctacagcaga ggccacagtc tgcacggtga cactggagaa gatgtcggca 121 gggctgggct tcagcctgga aggagggaag ggctccctac acggagacaa gcccctcacc 181 attaacagga ttttcaaagg agcagcctca gaacaaagtg agacagtcca gcctggagat 241 gaaatcttgc agctgggtgg cactgccatg cagggcctca cacggtttga agcctggaac 301 atcatcaagg cactgcctga tggacctgtc acgattgtca tcaggagaaa aagcctccag 361 tccaaggaaa ccacagctgc tggagactcc tag 1 tgcttaaaaa aacacaacag gattttcgaa gaatcctttc ttagaaaaca aacaaaaaaa 61 ccaaacaaaa acgtactttc tccccactag tttacaccac aggaagcgag agagctgctg 121 ccactgctgc taccacagga agacacagca gggagaagcc ctagtgcctc tgccggctgc 181 ccaggacctg gtatcggccc acagaccaag tcctccacag agggcgagcc agggtggaga 241 agagccagcc cagtgaccca aacatccccg ataaaacacc cactgcttaa gaggcaggct 301 cggatggact atagctttga taccacagcc gaagaccctt gggttaggat ttctgactgc 361 atcaaaaact tatttagccc catcatgagt gagaaccatg gccacatgcc tctacagccc 421 aatgccagcc tgaatgaaga agaagggaca cagggccacc cagatgggac cccaccaaag 481 ctggacaccg ccaatggcac tcccaaagtt tacaagtcag cagacagcag cactgtgaag 541 aaaggtcctc ctgtggctcc caagccagcc tggtttcgcc aaagcttgaa aggtttgagg 601 aatcgtgctt cagagccaag agggctccct gatcctgcct tgtccaccca gccagcacct 661 gcttccaggg agcacctagg atcacacatc cgggcctcct cctcctcctc ctccatcagg 721 cagagaatca gctcctttga aacctttggc tcctctcaac tgcctgacaa aggagcccag 781 agactgagcc tccagccctc ctctggggag gcagcaaaac ctcttgggaa gcatgaggaa 841 ggacggtttt ctggactctt ggggcgaggg gctgcaccca ctcttgtgcc ccagcagcct 901 gagcaagtac tgtcctcggg gtcccctgca gcctccgagg ccagagaccc aggtgtgtct 961 gagtcccctc ccccagggcg gcagcccaat cagaaaactt tcccccctgg cccggacccg 1021 ctcctaaggc tgctgtcaac acaggctgag gaatctcaag gcccagtgct caagatgcct 1081 agccagcgag cacggagctt ccccctgacc aggtcccagt cctgtgagac gaagctactt 1141 gacgaaaaga ccagcaaact ctattctatc agcagccaag tgtcatcggc tgtcatgaaa 1201 tccttgctgt gccttccatc ttctatctcc tgtgcccaga ctccctgcat ccccaaggca 1261 ggggcatctc caacatcatc atccaacgaa gactcagctg caaatggttc tgctgaaaca 1321 tctgccttgg acacggggtt ctcgctcaac ctttcagagc tgagagaata tacagagggt 1381 ctcacggaag ccaaggaaga cgatgatggg gaccacagtt cccttcagtc tggtcagtcc 1441 gttatctccc tgctgagctc agaagaatta aaaaaactca tcgaggaggt gaaggttctg 1501 gatgaagcaa cattaaagca attagacggc atccatgtca ccatcttaca caaggaggaa 1561 ggtgctggtc ttgggttcag cttggcagga ggagcagatc tagaaaacaa ggtgattacg 1621 gttcacagag tgtttccaaa tgggctggcc tcccaggaag ggactattca gaagggcaat 1681 gaggttcttt ccatcaacgg caagtctctc aaggggacca cgcaccatga tgccttggcc 1741 atcctccgcc aagctcgaga gcccaggcaa gctgtgattg tcacaaggaa gctgactcca 1801 gaggccatgc ccgacctcaa ctcctccact gactctgcag cctcagcctc tgcagccagt 1861 gatgtttctg tagaatctac agcagaggcc acagtctgca cggtgacact ggagaagatg 1921 tcggcagggc tgggcttcag cctggaagga gggaagggct ccctacacgg agacaagcct 1981 ctcaccatta acaggatttt caaaggagca gcctcagaac aaagtgagac agtccagcct 2041 ggagatgaaa tcttgcagct gggtggcact gccatgcagg gcctcacacg gtttgaagcc 2101 tggaacatca tcaaggcact gcctgatgga cctgtcacga ttgtcatcag gagaaaaagc 2161 ctccagtcca aggaaaccac agctgctgga gactcctagg caggacatgc tgaagccaaa 2221 gccaataaca cacagctaac acacagctcc cataaccgct gattctcagg gtctctgctg 2281 ccgccccacc cagatggggg aaagcacagg tgggcttccc agtggctgct gcccaggccc 2341 agaccttcta ggacgccacc cagcaaaagg ttgttcctaa aataagggca gagtcacact 2401 qgggcagctg atacaaattg cagactgtgt aaaaagagag cttaatgata atattgtggt 2461 gccacaaata aaatggattt attagaattc catatgacat tcatgcctgg cttcgcaaaa 2521 tgtttcaagt actgtaactg tgtcatgatt cacccccaaa cagtgacatt tatttttctc 2581 atgaatctgc aatgtgggca gagattggaa tgggcagctc atctctgtcc cacttggcat 2641 cagctggcgt catgcaaagt catgcaaagg ctgggaccac ctgagatcat tcactcatac 2701 atctggccgt tgatgttggc tgggaactca cctggggctg ctggcctgaa tgcttatagg 2761 tggcctctcc ttgtggcctg ggctcctcac aacatggtgt ctggattccc aggatgagca 2821 tcccaggatc gcaagagcca cgtagaagct gcatcttgtt tatacctttg ccttggaagt 2881 tgcatggcat cacctccacc atactccatc agttagagct gacacaaacc tgcctgggtt 2941 taaggggaga ggaaatattg ctggggtcat ttatgaaaaa tacagtttgt cacatgaaac 3001 atttgcaaaa ttgtttttgg ttggattgga gaagtaatcc tagggaaggg tggtggagcc WO 00/09525 1271 PCT/US99/17712 3061 agtaaataga ggagtacagg tgaagcacca agctcaaagc gtggacaggt gtgccgacag 3121 aaggaaccag cgtgtatatg agggtatcaa ataaaattgc tactacttac ctacc (2) INFORMATION FOR SEQ ID NO:102: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 9203 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:102: 1 gaattcatgc cacaactgag tgattttttt tttctcaaac ccaattccac aaagtaaaag 61 cctgatgaaa tacagtgaag gctgatgctt attaactgtg tttcccaaat ccagagctct 121 aaaaaggttc tgcatacagt cattcattca atgcttaacg actgagcatt aattccatgc 181 taagtactga actcagcact aggaataaga aggcgaccta gaggcatatc ctctctctaa 241 agatgcatag agcctcattg gaatgatcag ccgtgtctcc agagagctac aaggcagttt 301 tcaattggta aatgccctga gagtgatggg cttgtggcat gtgtaagggt tagacagacc 361 tgggacctag acatgacacc actcctgacg aattatgtga gtgtgggtgt ttcacaacca 421 caatgagatg caatgcctgc acttgtaaca tggaaatagc gatggcatgc cccgcagatt 481 gctgtgagaa gtcagcggca gagacatgca acattctcag cacagtgctt gccatgtagt 541 aagggcctag tcagtgctag tgattccttt caatattcct aagatgcaga taagggaaca 601 gcccagagga gggggagcac ttccagaggg aggaatgcgg tgagacttcc ttcagcaggg 661 tagcactgga gctgggtgtt aaggagtgag tgagctttgg gcttatggat ttaacagagg 721 aaaccaagaa aagaggaggc ggtgttgcag gaacagtgag cagttgatga tttttatttt 781 gttctctggt ctgcttggga acatttttgt ggcaaagaca gcatgaagga tagcgaagaa 841 ttaatactga agagataggc cagggcaggt tatgaaggat tttgaatacc Qggctaagaa 901 atgtgggctt aatttcaaag acattatgga cactcctaaa atgttacgtt gtagataagg 961 gaaaagtatt cttccagaag attaaattgg ggctgggcac ggtggctcac gcctgtgatc 1021 ccagcacttt gggaggcgaa gtgggcagat cacctgaggt caggagtttg agatcagcct 1081 ggccaacgtg gtgaagcccc atctctactg aaaaaaaaaa ttagccgggc atggtggtgg 1141 gtgcctgtaa tctcagctac ttgggaggct gaagcaggag aatcacatga acctgggagg 1201 cagaggttgc agtgagccaa gattgcacca ctgcattcca gtgggcgaca gagcaagact 1261 cagtcaaaaa aaaaaaaaga ttaaactgga agcaatgggt aagaatggtg gagtggagag 1321 acacatttga gtgagggaag ccagctgaaa agctgtacag acgtctagac aaaatgtgac 1381 acaagcatgc cttcacctcc ctgcaaagac cacagaccac tgagctccaa agggggtttg 1441 gaatccttgt cctgggccgc cattggtaac tcatcagtgc tggcttgaga gataaactct 1501 attatccatc cctgaactaa aatcatgaca gaagtggcca gggagctttg ctgctatccc 1561 cccaggaaac acgtcctcca ctcaaatgga aagaggaccc tctgacaaca tctgtgggac 1621 ccaacagcac tggtcaccac aagccacaaa atgttaacaa agtcagtttt caattgttag 1681 ggacggagga ctcagttcat gattcataca aaccaactgt tctctcccag tgttttctgg 1741 gtggcacaac ccacaagtca acagtggctt gggaactaga catttgagta gagttgggtt 1801 atttgattca tagtggattt tggttttcca cgggacccct gtgcccttgt ctagtagaat 1861 ctggtggaaa ttacaaactg cagaaattca actcagtgcc gcaataacag gatgcacctg 1921 tagatttcgt agaattagca gcagcattct ttcaatacca gtttgagaga aataaccctg 1981 tttgcatagt gccaactggg gcagaatctg aagtgtcttg cctgcctctc ggccatggga 2041 ggcaccgatc tcagcaacat ctatccaacc gccatccact taacaagcaa agatggaagg 2101 ccctcgtgct ccaggctatc ctgcaatggt tcatttgctt ttgatgggat tatcactttg 2161 acagatgtgc ttgcaattaa ctgggggctt tctgcttcca atccaaattc ccacaggtgg 2221 atcactggct cttggggagc aaaaaccctt ctttgtttgt ttttgcttct cccagagcct 2281 gggcagagct ccccattcct ggatcctacg ttgatatgca ctgaattgaa ttatactaaa 2341 gggtgcaccc aagagtgcat gagctaagta aaatgtaatt tgtgggacct catgtggaca 2401 tttcaggtcc atgtgtacaa gataaaggag agaaaatcct gggggacacc acaggcctgg 2461 gaaaatgacc tcctactaag cctaacaaga acatccagta cataaacagc aggctctctg 2521 caaccgcttc ggtccttcca ctgccacgct cccagaaagc aaagggttat ctcctgttcg 2581 gattttggct ctgagaccac agctcagcac atcactcctc tagagaaaag aaagtctaag 2641 atgagagagt gaggctgctt tcatgtggtg ccagcgtata gtgcagggca ggcctgattg 2701 ctgaacggat ccctgcagac gtgagcggtc acttcccctt ttgagggccc atttcttttc 2761 ctctttgagg agactgtgag cgtcctcagt gcagggctat gttttagctt cttggctctc 2821 ctcacaggtt ctagcataat tctttgatta attgcagtca acgtttattg atggattatg 2881 tgacagaggt gaaattcttt gatctgggtt tcagcttttc ctttccccca ctccctcctt 2941 tttctttttt tttttttttt tttttagagg cgaggtcttg ctctgtggcc ctggctggag 3001 tgcagtggtg caatcatagc tcattgcagc cttgacctcc tggggtcaag cgaacctcaa 3061 cgtcttggcc tcctgagtag ctgggactat aggcatgcgc caccacgctc agcttcacct 3121 tttcctttcc ttgtgctccc ctggcagata tgctggtaaa caatgaacca gtcaagagga 3181 cagcaacagg aggaaaatgg gagaaacccc attattcgtg gactaaacag gcttcccact 3241 ngtcctggct cacagaggaa gtcatgctcc atgtttcaaa tgtcctcaaa gctcgttcaa 3301 ctccaaaatg catgaagaca aaatgggaat tttactcaag atttttgtgg gctgttgggg 3361 agaagagtta acattgcaaa gcatattgca aactcttatc ttcaaatgat tttaaaattt 3421 tcttccaagc tctttattat ttctccagag ctgccctgct cttcccactc tgggtccttt 3481 ctctgccact ctcctcagca tgacttctcc ctaatcggcc agcatttctt ttattctata 3541 gagcaagttt tcttgccctg ggcacctctc atttgcatgt tataccacca caccaagtga 3601 gcctcagagc accagtgttt taatccctga aaacagtcct tacgggattc agcacagagg 3661 tcctcttggc agcctgtagt ctccagagtg acacgtcctc aacagtcaaa gtgagcaagc 3721 tatggtgccc atcaccaagt ggggctcacc atttccctct gcgttcactt ctctcctacc 3781 ttcttcctta tcccacct cctccttcct ttttttttct gcattcaatt attcatggtt 3841 attcatttca tacgggcatc tgtgccacat ggttctacag gcattttttt ttttgagaca WO 00/09525 1272 PCT/US99/17712 3901 gacttttgcc cttgtccccc aggctggcgt gcagcggtgt gatcttggct cactgcaatc 3961 tccacctcct aggttcaagc aagtctcctg ccttagcctc ccaagtagct ggaattacag 4021 gcatgtgcca ccaagcccgg caaatttttg tatttttagt agagacaggg tttcaccatq 4081 ttggccaggc tggtctcaaa ctcctgacct caggtgatct gcctgcctcg gcctcccaaa 4141 gtgctgggat aacaggcgtg agccatcgtg ctcggccggt tctatgggca ttgtggaagt 4201 gaccgttaac aagccccaag ggtaagtaaa ggaaaatgaa aggtgattga ttcctcacca 4261 cctctcccct tttttcctct actctttgcc cctgctcccc aatctagact ctaataaaca 4321 gaaatgattt ttgttgcaag ctgaaaactc gttcttgtgg ttgqggctag gggggtggca 4381 agtcaagctt tagagttgtc tggataataa atgctgtctt caaggactgt ccaacattgt 4441 aggaacaaga gaacaaccca agtgaacaac taactcctgt tcacaaatgc tactgcctct 4501 ctgccatccc ctaacctcag cctcacacac ttgaatttcg ccaatccatt tgatgagctc 4561 aaatcagtga attttctcct cgccaaagct cacaaattct gttccccgct tcttgcccca 4621 catccaggca ttaccaactg cattttccct ttgcctgata ttctggcatc aagcctcctt 4681 gccattccaa tttatttcac cttcctccag tccttatgat ttccttcctg aagagtattt 4741 cagcatctct atgcctcaat cttccctgca caccacacca gctcggcctc atcatcacat 4801 tacttggcta tgtcccgcct gggttagaca gcttcagtgg ctgaagtcca tagatcttat 4861 tctgtttttc gaggtccacc tgactctgaa tccagctgac atttctgccc ttagcttcta 4921 cccctctcta cttctggtta actatggacc acactctgct tcctcaggaa ccacctacca 4981 aggccgtatc catccttcaa ggacaatacg tgggcctttc ctgatcacat cagctcaaca 5041 acttttccct cctacatttc aattgctctt cttaccataa tcattagtat tcaccccact 5101 gtacgtctag aaagaaagtg gtcttaaacc taagggaagg cagtctaggt cagaaatttg 5161 ttgtccgctg ttctgagcag tttcttctag gaagtaccaa acatttctga taatagaatt 5221 gagcaatttc ctgatgaagt gagactcagc ttgcactgtt gaccggctgt cctggatgaa 5281 cctagttact tttaaccaaa tgttcctttc ttgaacttgt tcctttcttg aacttaatct 5341 atcaatgtta tctagataac tttcctcaaa aaaaaaaaaa aaaaaaaaaa ccctctacta 5401 ggaaagaaat ctttgaaccg gacttattgg aaattacctc cttgcagcag gtttgaaaca 5461 aaactttgaa tttgcctcac aaagaatttg tctgaaactg ctttagtata tgctagttat 5521 atttgtatgc acatgtggct tcatacatag tggttggaca cccatatgtg ttatgcactt 5581 tgttaggtga cgtaagttca cagataaact ggaacatagg gctatcctct agaggcccac 5641 agtttgacac cttaacctga gatccttgga cctttgaagt tcagagtgcc cacaaccgct 5701 gggtgtggtg gctcacactt gtaatcccag tactctgcag ggctgaggtg ggaggatcgc 5761 ttgagtccag gagtctgaga ccagcctggg caacatgaca aaaccccatc tctacaaaaa 5821 ttacaaaaaa aattagccag gcctggtggt gcatgcctgt ggtcccagtt acttgagagg 5881 ctgaagtggg aggatcactt gagtcaagga ggtagaggct gcagtgagtt gagatggcaa 5941 cactgcactc cagaaacccc atctcaaaca aaacagagca aaacaaaaca aactgcccat 6001 aatgctcctg aaacttccta cggatttatc cagagtatgt gctgatgtgc attttttcca 6061 aggagggaaa ccaaaggttc tatcaaatta agaaaagagt ttttaccatt gtggaagaca 6121 gtatggcgat tcctcaagca tctaaaatca gaaataccat ttgacccagc aatcctatta 6181 ctgggtatat acccaaagga atagaaatca ttctactata aagtcacatg caaccgtatg 6241 tttattgcag cactatttac aatagcaaaa tggaaccaac tgaaatgccc atcaatgaga 6301 ctagataaag aaaatgtgat acatatacac catggaatac tatgcagcca tgaaaaggaa 6361 tgagatcacg tccttggcag ggacatggat gaagctggaa gccattatcc tcagcaaact 6421 aacacaggaa cagaaaacca aatgccgcat gttctcactc ataagtggga gttgaacaat 6481 gacagcacat agacataggg aggggaacat cacacgccag ggcctgctgc agggtggggg 6541 gtggggtgtg aggggaggga acttagaaga caggtgagta ggtgcagcag accaccatgg 6601 cacacttata cctatgtaac caacctgcac gttctacaca tgtatcctgg aacttaaatt 6661 aaaaacaaaa aagagttttt aatccaagaa agattaacag caactagaag aaagaaagag 6721 atataaacag tgaattgcaa tgcagcacgg caggtgttat gatggagtag aaaggactgg 6781 aaaaggcctc ctggaggaag ggacactcaa gtgtctttcc atttcacctg taaactcatt 6841 aagggcaaaa gctttgctac agcttcagta tgagatcctg ggcaatccgt gacaaaatgg 6901 gtctgctttt gcacccccaa cttcttctca catccctgca tcgtgccatg cagcatcaac 6961 tggaaacctc agcgtcagca aacgacgaca gagcgttcat ccgtaaggtg aaccagaaaa 7021 gccagttcaa tgacttgttt aaccatggtc catctcagaa ccaagagttg ggcctcttat 7081 ttaccagaaa aattgtgggg gctttgtgat atggctttaa aaaaatcttg taattgccag 7141 gcgtggtggc tcacacctgt aatcccagca ctttgggagg ccgaggtggg tgaatcgcct 7201 aaggtcagga gttcgagacc agcctgacca acatggtgaa actccgtctc tactaaaaat 7261 acaaaaacta gctggatgtg gtgacgcgtg cctgtaatcc tagctactca ggaggctgac 7321 gcaggagaat cacttgaacc tgggaggcag aggttgcagt gagccaagat tgtgccattg 7381 cgctccaaaa aaaaaaaaaa aatacattaa cataaattta aatattttat aatgacaatc 7441 cacattaact acttaaagca taagctattt tccaggagag gcagcaagtg cattctactc 7501 ccatgcccaa gaagaaagga gcgtgacttt ggtgggagta ctaggagttt ctactggagc 7561 acttgcccgc agagtgagaa acgttcctag agaggaagtt atacctgctg tggaatttaa 7621 gagaatcttg tcatattttg acaagttttt tgagatggaa gtctcactct gtcgcccagg 7681 ctggagtgca gtggcgcaat ctcagctcac tgcagcctgc acctcctcgg ttccagctat 7741 tctcttgtct cagcctcctg agtaactggg attacaggcg cccgccacta cgcctggcta 7801 atttttgtat ttttagtaga aatggggttt taccatgttg gccagactgg tctcaaactc 7861 ccgacctcag gtgatctgcc tgcctcagcc tcccaaagtg ctggaattac aggcgtgtgc 7921 cactgcgcct ggctaatttt tttttttttt tttttttagt agagacggtg gtttcaccat 7981 gtcatccagg ctggtctcaa actcctgacc tcaggtgatc cacccacctt ggtctaccaa 8041 agtgctcgga ttacaggcat gagccaccag gcccagtcaa cgtgatgtgt tttggaaccc 8101 tgaattcctt ggcttgccgg agggttttct ttttgttaat atctttgctt gctttctagt 8161 atttaaaaaa ttgtgttttg ctctaactat gcaatggctt taagtcttag acaaatttcc 8221 agggagcaaa acacactcaa ccaatttcat aataatcaga agagagctct gatcaataaa 8281 taagcaagac tgaatttcac aaaataatcc aaagtttaaa accaaagccc actttttgca 8341 tgatccttta agagaaagaa atctggaagc aaaacacctt ataaaatgac aatgcacttt WO 00/09525 1273 PCT/US99/17712 8401 caggagccca gggcactgtg gtgaaatgat gatggctagt acaggttata agccttgggg 8461 aattatttat gaattctcag gatccttcag ttcgccgcat ccttctccat tatttaaata 8521 ttggaggctg cctgaccaga atcttgtcag gactttgctc cttcatccca ggtggtcccg 8581 gctgactcct gaggacgtta cagccctgag gggaggactc agcttatgaa gtgctgggtg 8641 agaccactgc caagaagtgc ttgctcaccc taccttcaac ggcaggggaa tctccctctc 8701 cttttatggg cgtagctgaa gaaaggattc ataaatgaag ttcaatcctt ctcatcaacc 8761 ccagcccaca cctccagcaa ttgaacttga aaaaaaaaac ctggtttgaa aaattaccgc 8821 aaactatatt gtcatcaaaa aaaaaaaaaa aaaaacactt cctatatttg agatgagaga 8881 agagagtgct aggcagtttc ctggctgaac acgccagccc aatacttaaa gagagcaact 8941 cctgactccg atagagactg gatggaccca caagggtgac agcccaggcg gaccgatctt 9001 cccatcccac atcctccggc gcgatgccaa aaagaggctg acggcaactg ggccttctgc 9061 agagaaagac ctccgcttca ctgccccggc tggtcccaag ggtcaggaag atggattcat 9121 acctgctgat gtggggactg ctcacgttca tcatggtgcc tggctgccag gcaggtaagg 9181 gcctgtgggt gcccccggaa ttc (2) INFORMATION FOR SEQ ID NO:103: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 2335 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:103: 1 gaattccccc cccccccccc cgagagactg gatggaccca caagggtgac agcccaggcg 61 gaccgatctt cccatcccac atcctccggc gcgatgccaa aaagaggctg acggcaactg 121 ggccttctgc agagaaagac ctccgcttca ctgccccggc tggtcccaag ggtcaggaag 181 atggattcat acctgctgat gtggggactg ctcacgttca tcatggtgcc tggctgccag 241 gcagagctct gtgacgatga cccgccagag atcccacacg ccacattcaa agccatggcc 301 tacaaggaag gaaccatgtt gaactgtgaa tgcaagagag gtttccgcag aataaaaagc 361 gggtcactct atatgctctg tacaggaaac tctagccact cgtcctggga caaccaatgt 421 caatgcacaa gctctgccac tcggaacaca acgaaacaag tgacacctca acctgaagaa 481 cagaaagaaa ggaaaaccac agaaatgcaa agtccaatgc agccagtgga ccaagcgagc 541 cttccaggtc actgcaggga acctccacca tgggaaaatg aagccacaga gagaatttat 601 catttcgtgg tggggcagat ggtttattat cagtgcgtcc agggatacag ggctctacac 661 agaggtcctg ctgagagcgt ctgcaaaatg acccacggga agacaaggtg gacccagccc 721 cagctcatat gcacaggtga aatggagacc agtcagtttc caggtgaaga gaagcctcag 781 gcaagccccg aaggccgtcc tgagagtgag acttcctgcc tcgtcacaac aacagatttt 841 caaatacaga cagaaatggc tgcaaccatg gagacgtcca tatttacaac agagtaccag 901 gtagcagtgg ccggctgtgt tttcctgctg atcagcgtcc tcctcctgag tgggctcacc 961 tggcagcgga gacagaggaa gagtagaaga acaatctaga aaaccaaaag aacaagaatt 1021 tcttggtaag aagccgggaa cagacaacag aagtcatgaa gcccaagtga aatcaaaggt 1081 gctaaatggt cgcccaggag acatccgttq tgcttgcctg cgttttggaa gctctgaagt 1141 cacatcacag gacacggggc agtggcaacc ttgtctctat gccagctcag tcccatcaga 1201 gagcgagcgc tacccacttc taaatagcaa tttcgccgtt gaagaggaag ggcaaaacca 1261 ctagaactct ccatcttatt ttcatgtata tgtgttcatt aaagcatgaa tggtatggaa 1321 ctctctccac cctatatgta gtataaagaa aagtaggttt acattcatct cattccaact 1381 tcccagttca ggagtcccaa ggaaagcccc agcactaacg taaatacaca acacacacac 1441 tctaccctat acaactggac attgtctgcg tggttccttt ctcagccgct tctgactgct 1501 gattctcccg ttcacgttgc ctaataaaca tccttcaaga actctgggct gctacccaga 1561 aatcatttta cccttggctc aatcctctaa gctaaccccc ttctactgag ccttcagtct 1621 tgaatttcta aaaaacagag gccatggcag aataatcttt gggtaacttc aaaacggggc 1681 agccaaaccc atgaggcaat gtcaggaaca gaaggatgaa tgaggtccca ggcagagaat 1741 catacttagc aaagttttac ctgtgcgtta ctaattggcc tctttaagag ttagtttctt 1801 tgggattgct atgaatgata ccctgaattt ggcctgcact aatttgatgt ttacaggtgg 1861 acacacaagg tgcaaatcaa tgcgtacgtt tcctgagaag tgtctaaaaa caccaaaaag 1921 ggatccgtac attcaatgtt tatgcaagga aggaaagaaa gaaggaagtg aagagggaga 1981 agggatggag gtcacactgg tagaacgtaa ccacggaaaa gagcgcatca ggcctggcac 2041 ggtggctcag gcctataacc ccagctccct aggagaccaa ggcgggagca tctcttgagg 2101 ccaggagttt gagaccagcc tgggcagcat agcaagacac atccctacaa aaaattagaa 2161 attggctgga tgtggtggca tacgcctgta gtcctagcca ctcaggaggc tgaggcagga 2221 ggattgcttg agcccaggag ttcgaggctg cagtcagtca tgatggcacc actgcactcc 2281 agcctgggca acagagcaag atcctgtctt taaggaaaaa aagacaaggg aattc (2) INFORMATION FOR SEQ ID NO: 104: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1092 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:104: 1 gaattcatgg aaatgggaag ggcagtgatg gagatgggaa gggcagtggg ggttggaggg 61 gtggggaatg ttgttgggta cgaaaacaga attagatcga atgaataaga tctagtattt 121 gatagcataa cagggtgact ttagtcaaca ataatttatt gtacatttaa aaataactaa 181 aagagtatac ttggatttta acacaaagaa aggataaata cttgaggtga tggatacccc 241 atttaccctg atgtgattat tatacattgt atgcctgtat caaaatagct catgtgcctc WO 00/09525 1274 PCT/US99/17712 301 atgaatatag acacctacca catgcccaca aaattaaaaa ctaaaaaaaa cagtcatctc 361 tgaatgctaa acggagtaag gggcttcctg gaaggctggg tgaaatggga gtctcggaaa 421 gatggtgtgt tgcaggctgg gaggagggtg agacgctggg gtcacctaga gggacctgct 481 tgtgtgaagc ctacgtatta gtgggtatgt gtgtgaccgg atggaggcgt cagaggtgtt 541 gggtagcctg tgtgagttgg cgtgggggtg atgtaggagg ggagagaggg agggcctgcg 601 ttcccttggc tcctgtgtgc agctaggccc ctatttgaca atgtgtgtct gtgtgtgtgt 661 gtgtgtgtgt gtgtgtgtgt gtgtgccgcc cccagcgtag gaggcagatc tttatctggc 721 cctgggtgct tgaggagttt caggctttct cataagcctc gtctccccgc ctctccaccc 781 caggccttgc ccctctatcc tctgcacagg aagtgggctg gctctgggct tttagtcttt 841 gcggccccag cagccaqagc tcagcagggc cctggagaga tggccacggt cccagcaccg 901 gggaggactg gagagcgcgc gctgccaccg ccccatgtct cagccaggtg atgtccccct 961 gcctccctcc cggcccctgt ggaccagcca gagggctggg agtgaaagtc acagagaaga 1021 ctttcagctc tgactcagtt cccccagcag tttctgcctg aactcccatc ccccaacttt 1081 gtcttagaat tc (2) INFORMATION FOR SEQ ID NO:105: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1451 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:105: 1 gaagagcaag cgccatgttg aagccatcat taccattcac atccctctta ttcctgcagc 61 tgcccctgct gggagtgggg ctgaacacga caattctgac gcccaatggg aatgaagaca 121 ccacagctga tttcttcctg accactatgc ccactgactc cctcagtgtt tccactctgc 181 ccctcccaga ggttcagtgt tttgtgttca atgtcgagta catgaattgc acttggaaca 241 gcagctctga gccccagcct accaacctca ctctgcatta ttggtacaag aactcggata 301 atgataaagt ccagaagtgc agccactatc tattctctga agaaatcact tctggctgtc 361 agttgcaaaa aaaggagatc cacctctacc aaacatttgt tgttcagctc caggacccac 421 gggaacccag gagacaggcc acacagatgc taaaactgca gaatctggtg atcccctggg 481 ctccagagaa cctaacactt cacaaactga gtgaatccca gctagaactg aactggaaca 541 acagattctt gaaccactgt ttggagcact tggtgcagta ccggactgac tgggaccaca 601 gctggactga acaatcagtg gattatagac ataagttctc cttgcctagt gtggatgggc 661 agaaacgcta cacgtttcgt gttcggagcc gctttaaccc actctgtgga agtgctcagc 721 attggagtga atggagccac ccaatccact gggggagcaa tacttcaaaa gagaatcctt 781 tcctgtttgc attggaagcc gtggttatct ctgttggctc catgggattg attatcagcc 841 ttctctgtgt gtatttctgg ctggaacgga cgatgccccg aattcccacc ctgaagaacc 901 tagaggatct tgttactgaa taccacggga acttttcggc ctggagtggt gtgtctaagg 961 gactggctga gagtctgcag ccagactaca gtgaacgact ctgcctcgtc agtgagattc 1021 ccccaaaagg aggggccctt ggggaggggc ctggggcctc cccatgcaac cagcatagcc 1081 cctactgggc ccccccatgt tacaccctaa agcctgaaac ctgaacccca atcctctgac 1141 agaagaaccc cagggtcctg tagccctaag tggtactaac tttccttcat tcaacccacc 1201 tgcgtctcat actcacctca ccccactgtg gctgatttgg aattttgtgc ccccatgtaa 1261 gcaccccttc atttggcatt ccccacttga geattaccct tttgccccga acatgttttt 1321 cttctccctc agtctggccc ttccttttcg caggattctt cctccctccc tctttccctc 1381 ccttcctctt tccatctacc ctccgattgt tcctgaaccg atgagaaata eagttoogt 1441 tgataatcat c (2) INFORMATION FOR SEQ ID NO:106: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1563 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:106: gagagactgg atggacccac aaggggaca gcccaggcgg accgatcttc ccatcccaca 61 tcctccggcg cgatgccaaa aagaggctga cggcaactgg gccttctgca gagaaagacc 121 tccgcttcac tgccccggct ggtcccaagg gtcaggaaga tggattcata cctgctgatg 181 tggggactgc tcacgttcat catggtgcct ggctgccagg cagagctctg tgacgatgac 241 ccgccagaga tcccacacgc cacattcaaa gccatggcct acaaggaagg aaccatgttg 301 aactgtgaat gcaagagagg tttccgcaga ataaaaagcg ggtcactcta tatgctctgt 361 acaggaaact ctagccactc gtcctgggac aaccaatgtc aatgcacaag ctctgccact 421 cggaacacaa cgaaacaagt gacacctcaa cctgaagaac agaaagaaag gaaaaccaca 481 gaaatgcaaa gtccaatgca gccagtggac caagcgagcc ttccaggtga agagaagcct 541 caggcaagcc ccgaaggccg tcctgagagt gagacttcct gcctcgtcac aacaacagat 601 tttcaaatac agacagaaat ggctgcaacc atggagacgt ccatatttac aacagagyac 661 caggtagcag tggccggctg tgttttcctg ctgatcagcg tcctcctcct gagtgggctc 721 acctggcagc ggagacagag gaagagtaga agaacaatct agaaaaccaa aagaacaaga 781 atttcttggt aagaagccgg gaacagacaa cagaagtcat gaagcccaag tgaaatcaaa 841 ggtgctaaat ggtcgcccag gagacatccg ttgtgcttgc ctgcgttttg gaagctctga 901 agtcacatca caggacacgg ggcagtggca accttgtctc tatgccagct cagtcccatc 961 agagagcgag cgctacccac ttctaaatag caatttcgcc gttgaagagg aagggcaaaa 1021 ccactageac gctccatctt attttcatgt atatgtgttc attaaagcat gaatggatg 1081 gaactctctc cacccatat gtagtataaa gaaaagtagg ttctacattca tctcattcca 1141 acttcccagt tcaggagtcc caaggaaagc cccagcacta acgtaaatac acaacacaca WO 00/09525 1275 PCTIUS99/17712 1201 cactctaccc tatacaactg gacattgtct gcgtggttcc tttctcagcc gcttctgact 1261 gctgattctc ccgttcacgt tgcctaataa acatccttca agaactctgg gctgctaccc 1321 agaaatcatt ttacccttgg ctcaatcctc taagctaacc cccttccact gagccttcag 1381 tcttgaattt ctaaaaaaca gaggccatgg cagaataatc tttgggtaac ttcaaaacgg 1441 ggcagccaaa cccatgaggc aatgtcagga acagaaggat gaatgaggtc ccaggcagag 1501 aatcatactt agcaaagttt tacctgtgcg ttactaattg gcctctttaa gagttagttt 1561 ctt (2) INFORMATION FOR SEQ ID NO:107: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 733 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:107: 1 gaattctcag gatccttcag ttcgccgcat ccttctccat tatttgaata ttggaggctg 61 cctgaccaga atcttgtcag gactttgctc cttcatccca ggtggtcccg gctgactcct 121 gaggacgtta cagccctgag gggaggactc agccttatga agtgctgggt gagaccactg 181 ccaagaagtg cttgctcacc ctaccttcaa cggcagggga atctccctct ccttttatgg 241 gcgtagtgaa gaaaggattc ataaatgaag ttcaatcctt ctcatcaacc ccagcccaca 301 cctccagcaa ttgaacttga aaaaaaaaac ctggtttgaa aaattaccgc aaactatatt 361 gtcatcaaaa aaaaaaaaaa aaaaacactt cctatattig agatgagaga agagagtgct 421 aggcagtttc ctggctgaac acgccagccc aatacttaaa gagagcaact cctgactccg 481 atagagactg gatggaccca caagggtgac agcccaggcg gaccgatctt cccatcccac 541 atcctccggc gcgatgccaa aaagaggctg acggcaactg ggccttctgc agagaaagac 601 ctccgcttca ctgccccggc tggtcccaag ggtcaggaag atggattcat acctgctgat 661 gtggggactg ctcacgttca tcatggtgcc tggctgccag gcaggtaagg gcctgtgggt 721 gcccccggaa ttc (2) INFORMATION FOR SEQ ID NO:108: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 756 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:108: 1 gagctctgtg acgatgaccc gccagagatc ccacacgcca cattcaaagc catggcctac 61 aaggaaggaa ccatgttgaa ctgtgaatgc aagagaggtt tccgcagaat aaaaagcggg 121 tcactctata tgctctgtac aggaaactct agccactcgt cctgggacaa ccaatgtcaa 181 tgcacaagct ctgccactcg gaacacaacg aaacaagtga cacctcaacc tgaagaacag 241 aaagaaagga aaaccacaga aatgcaaagt ccaatgcagc cagtggacca agcgagcctt 301 ccaggtcact gcaaggaacc tccaccatgg gaaaatgaag ccacagagag aatttatcat 361 ttcgtggtgg ggcagatggt ttattatcag tgcgtccagg gatacagggc tctacacaga 421 ggtcctgctg agagcgtctg caaaatgacc cacgggaaga caaggtggac ccagccccag 481 ctcatatgca caggtgaaat ggagaccagt cagtttccag gtgaagagaa gcctcaggca 541 agccccgaag gccgtcctga gagtgagact tcctgcctcg tcacaacaac agattttcaa 601 atacagacag aaatggctgc aaccatggag acgtccatat ttacaacaga gtaccaggta 661 gcagtggccg gctgtgtttt cctgctgatc agcgtcczcc tcctgagtgg gctcacctgg 721 cagcagagac agaggaagag tagaagaaca atctag (2) INFORMATION FOR SEQ ID NO:109: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 711 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:109: 1 gaattctcag gatccttcag ttcgccgcat ccttctccat tatttgaata ttggaggctg 61 cctgaccaga atcttgtcag gactttgctc cttcatccca ggtggtcccg gctgactcct 121 gaggacgtta cagccctgag ggaggactca gcttatgaag tgctgggtga gaccactgcc 181 aagaagtgct tgctcaccta ccttcaacgg caggggaatc tccctctcct tttatgggcg 241 tagctgaaga aaggattca aaatgaagtt caatccttct catcacccca gcccaacctc 301 cagcaattga acttgaaaaa aaaaacctgg tttgaaaaat taccgcaaac tatattgtca 361 tcaaaaaaaa aaaaaaaaaa aaacacttcc tatatttgag atgagagaag agagtgctag 421 gcagtttcct ggctgaacac gccagcccaa tacttaaaga gagcaactcc tgactccgat 481 agagactgga tggacccaca aggggacag cccaggcgga ccgatcttcc catcccacat 541 cctccggcgc gatgccaaaa agaggctgac ggcaactggg ccttctgcag agaaagacct 601 ccgcttcact gccccggctg gtcccaaggg tcaggaagat ggattcatac ctgctgatgt 661 ggggactgct cacgttcatc atggtgcctg gctgccaggc aggtaagggc c (2) INFORMATION FOR SEQ ID NO:110: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18200 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single WO 00/09525 1276 PCT/US99/17712 (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:110: 1 gaattcatgc cacaactgag tgattttttt tttctcaaac ccaattccac aaagtaaaag 61 cctgatgaaa tacagtgaag gctgatgctt attaactgtg tttcccaaat ccagagctct 121 aaaaaggttc tgcatacagt cattcattca atgcttaacg actgagcatt aattccatgc 181 taagtactga actcagcact aggaataaga aggcgaccta gaqgcatatc ctctctctaa 241 agatgcatag agcctcattg gaatgatcag ccgtgtctcc agagagctac aaggcagttt 301 tcaattggta aatgccctga gagtgatggg cttgtggcat gtgtaagggt tagacagaco 361 tgggacctag acatgacacc actcctgacg aattatgtga gtgtgggtgt ttcacaacca 421 caatgagatg caatgcctgc acttgtaaca tggaaatagt gatggcatgc cccgcagatt 481 gctgtgagaa gtcagcggca gagacatgca acattctcag cacagtgctt gccatgtagt 541 aagggcctag tcagtgctag tgattccttt caatattcct aagatgcaga taagggaaca 601 gcccagagga gggggagcac ttccagaggg aggaatgcgg tgagacttcc ttcagcaggg 661 tagcactgga gctgggtgtt aaggagtgag tgagctttgg gcttatggat ttaacagagg 721 aaaccaagaa aagaggaggc ggtgttgcag gaacagtgag cagttgatga tttttatttt 781 gttctctggt ctgcttggga acatttttgt ggcaaagaca gcatgaagga tagcgaagaa 841 ttaatactga agagataggc cagggcaggt tatgaaggat tttgaatacc gggctaagaa 901 atgtgggctt aatttcaaag acattatgga cactcctaaa atgttacgtt gtagataagg 961 gaaaagtatt cttccagaag attaaattgg ggctgggcac ggtggctcac gcctgtgatc 1021 ccagcacttt gggaggcgaa gtgggcagat cacctgaggt caggagtttg agatcagcct 1081 ggccaacgtg gtgaagcccc atctctactg aaaaaaaaaa ttagccgggc atggtggtgg 1141 gtgcctgtaa tctcagctac ttgggaggct gaagcaggag aatcacatga acctgggagg 1201 cagaggttgc agtgagccaa gattgcacca ctgcattcca gtgggcgaca gagcaagact 1261 cagtcaaaaa aaaaaaaaga ttaaactgga agcaatgggt aagaatggtg gagtggagag 1321 acacatttga gtgagggaag ccagctgaaa agctgtacag acgtctagac aaaatgtgac 1381 acaagcatgc cttcacctcc ctgcaaagac cacagaccac tgagctccaa agggggtttg 1441 gaatccttgt cctgggccgc cattggtaac tcatcagtgc tggcttgaga gataaactct 1501 attatccatc cctgaactaa aatcatgaca gaagtggcca gggagctttg ctgctatccc 1561 cccaggaaac acgtcctcca ctcaaatgga aagaggaccc tctgacaaca tctgtgggac 1621 ccaacagcac tggtcaccac aagccacaaa atgttaacaa agtcagtttt caattgttag 1681 ggacggagga ctcagttcat gattcataca aaccaactgt tctctcccag tgttttctgg 1741 gtggcacaac ccacaagtca acagtggctt gggaactaga catttgagta gagttgggtt 1801 atttgattca tagtggattt tggttttcca cgggacccct gtgcccttgt ctagtagaat 1861 ctggtggaaa ttacaaactg cagaaattca actcagtgcc gcaataacag gatgcacctg 1921 tagatttcgt agaattagca gcagcattct ttcaatacca gtttgagaga aataaccctg 1981 tttgcatagt gccaactggg gcagaatctg aagtgtcttg cctgcctctc ggccatggga 2041 ggcaccgatc tcagcaacat ctatccaacc gccatccact taacaagcaa agatggaagg 2101 ccctcgtgct ccaggctatc ctgcaatggt tcatttgctt ttgatgggat tatcactttg 2161 acagatgtgc ttgcaattaa ctgggggctt tctgcttcca atccaaattc ccacaggtgg 2221 atcactggct cttggggagc aaaaaccctt ctttgtttgt ttttgcttct cccagagcct 2281 gggcagagct ccccattcct ggatcctacg ttgatatgca ctgaattgaa ttatactaaa 2341 gggtgcaccc aagagtgcat gagctaagta aaatgtaatt tgtgggacct catgtggaca 2401 tttcaggtcc atgtgtacaa gataaaggag agaaaatcct gggggacacc acaggcctgg 2461 gaaaatgacc tcctactaag cctaacaaga acatccagta cataaacagc aggctctctg 2521 caaccgcttc ggtccttcca ctgccacgct cccagaaagc aaagggttat ctcctgttcg 2581 gattttggct ctgagaccac agctcagcac atcactcctc tagagaaaag aaagtctaag 2641 atgagagagt gaggctgctt tcatgtggtg ccagcgtata gtgcagggca ggcctgattg 2701 ctgaacggat ccctgcagac gtgagcggtc acttcccctt ttgagggccc atttcttttc 2761 ctctttgagg agactgtgag cgtcctcagt gcagggctat gttttagctt cttggctctc 2821 ctcacaggtt ctagcataat tctttgatta attgcagtca acgtttattg atggattatg 2881 tgacagaggt gaaattcttt gatctgggtt tcagcttttc ctttccccca ctccctcctt 2941 tttctttttt tttttttttt tttttagagg cgaggtcttg ctctgtggcc ctggctggag 3001 tgcagtggtg caatcatagc tcattgcagc cttgacctcc tggggtcaag cgaacctcaa 3061 cgtcttggcc tcctgagtag ctgggactat aggcatgcgc caccacgctc agcttcacct 3121 tttcctttcc ttgtgctccc ctggcagata tgctggtaaa caatgaacca gtcaagagga 3181 cagcaacagg aggaaaatgg gagaaacccc attattcgtg gactaaacag gcttcccact 3241 agtcctggct cacagaggaa gtcatgctcc atgtttcaaa tgtcctcaaa gctcgttcaa 3301 ctccaaaatg catgaagaca aaatgggaat tttactcaag atttttgtgg gctgttgggg 3361 agaagagtta acattgcaaa gcatattgca aactcttatc ttcaaatgat tttaaaattt 3421 tcttccaagc tctttattat ttctccagag ctgccctgct cttcccactc tgggtccttt 3481 ctctgccact ctcctcagca tgacttctcc ctaatcggcc agcatttctt ttattctata 3541 gagcaagttt tcttgccctg ggcacctctc atttgcatgt tataccacca caccaagtga 3601 gcctcagagc accagtgrtt taatccctga aaacagtcct tacgggattc agcacagagg 3661 tcctcttggc agcctgtagt ctccagagtg acacgtcctc aacagtcaaa gtgagcaagc 3721 tatggtgccc atcaccaagt ggggctcacc atttccctct gcgttcactt ctctcctacc 3781 ttcttcctta tcccatcctt cctccttcct ttttttttct gcattcaatt attcatggtt 3841 attcatttca tacgggcatc tgtgccactt ggttctacag gcattttttt ttttgagaca 3901 gactttracc cttgtccccc aggctggcgt gcagcggtgt gatcttggct cactgcaatc WO 00/09525 1277 PCT/US99/17712 3961 tccacctcct aggttcaagc aagtctcctg ccttagcctc ccaagtagct ggaattacag 4021 gcatgtgcca ccaagcccgg caaatttttg tatttttagt agagacaggg tttcaccatg 4081 ttggccaggc tggtctcaaa ctcctgacct caggtgatct gcctgcctcg gcctcccaaa 4141 gtgctgggat aacaggcgtg agccatcgtg ctcggccggt tctatgggca ttgtggaagt 4201 gaccgttaac aagccccaag ggtaagtaaa ggaaaataaa aggtgattga ttcctcacca 4261 cctctcccct tttttcctct actctttgcc cctgctcccc aatctagact ctaataaaca 4321 gaaatgattt ttgttgcaag ctgaaaactc gttcttgtgg ttggggctag gggggtggca 4381 agtcaagctt tagagttgtc tggataataa atgctgtctt caaggactgt ccaacattgt 4441 aggaacaaga gaacaaccca agtgaacaac taactcctgt tcacaaatgc tactgcctct 4501 ctgccatccc ctaacctcag cctcacacac ttgaatttcg ccaatccatt tgatgagctc 4561 aaatcagtga attttctcct cgccaaagct cacaaattct gttccccgct tcttgcccca 4621 catccaggca ttaccaactg cattttccct ttgcctgata ttctggcatc aagcctcctt 4681 gccattccaa tttatttcac cttcctccag tccttatgat ttccttcctg aagagtattt 4741 cagcatctct atgcctcaat cttccctgca caccacacca gctcggcctc atcatcacat 4801 tacttggcta tgtcccgcct gggttagaca gcttcagtgg ctgaagtcca tagatcttat 4861 tctgtttttc gaggtccacc tgactctgaa tccagctgac atttctgccc ttagcttcta 4921 cccctctcta cttctggtta actatggacc acactctgct tcctcaggaa ccacctacca 4981 aggccgtatc catccttcaa ggacaatacg tgggcctttc ctgatcacat cagctcaaca 5041 acttttccct cctacatttc aattgctctt cttaccataa tcattagtat tcaccccact 5101 gtacgtctag aaagaaagtg gtcttaaacc taagggaagg cagtctaggt cagaaatttg 5161 ttgtccgctg ttctgagcag tttcttctag gaagtaccaa acatttctga taatagaatt 5221 gagcaatttc ctgatgaagt gagactcagc ttgcactgtt gaccggctgt cctggatgaa 5281 cctagttact tttaaccaaa tgttcctttc ttgaacttgt tcctttcttg aacttaatct 5341 atcaatgtta tctagataac tttcctcaaa aaaaaaaaaa aaaaaaaaaa ccctctacta 5401 ggaaagaaat ctttgaaccg gacttattgg aaattacctc cttgcagcag gtttgaaaca 5461 aaactttgaa ttgcctcac aaagaatttg tctgaaactg ctttagtata tgctagttat 5521 atttgtatgc acatgtggct tcatacatag tggttggaca cccatatgtg ttatgcactt 5581 tgttaggtga cgtaagttca cagataaact ggaacatagg gctatcctct agaggcccac 5641 agtttgacac cttaacctga gatccttgga cctttgaagt tcagagtgcc cacaaccgct 5701 gggtgtggtg gctcacactt gtaatcccag tactctgcag ggctgaggtg ggaggatcgc 5761 ttgagtccag gagtctgaga ccagcctggg caacatgaca aaaccccatc tctacaaaaa 5821 ttacaaaaaa aattagccag gcctggtggt gcatgcctgt ggtcccagtt acttgagagg 5881 ctgaagtggg aggatcactt gagtcaagga ggtagaggct gcagtgagtt gagatggcaa 5941 cactgcactc cagaaacccc atctcaaaca aaacagagca aaacaaaaca aactgcccat 6001 aatgctcctg aaacttccta cggatttatc cagagtatgt g tgatgtgc attttttcca 6061 aggagggaaa ccaaaggttc tatcaaatta agaaaagagt ttttaccatt gtggaagaca 6121 gtatggcgat tcctcaagca tctaaaatca gaaataccat ttgacccagc aatcctatta 6181 ctgggtatat acccaaagga atagaaatca ttctactata aagtcacatg caaccgtatg 6241 tttattgcag cactatttac aatagcaaaa tggaaccaac tgaaatgccc atcaatgaga 6301 ctagataaag aaaatgtgat acatatacac catggaatac tatgcagcca tgaaaaggaa 6361 tgagatcacg tccttggcag ggacatggat gaagctggaa gccattatcc tcagcaaact 6421 aacacaggaa cagaaaacca aatgccgcat gttctcactc ataagtggga gttgaacaat 6481 gacagcacat agacataggg aggggaacat cacacgccag ggcctgctgc agggtggggg 6541 qtggggtgtg aggggaggga acttagaaga caggtgagta ggtgcagcag accaccatgg 6601 cacacttata cctatgtaac caacctgcac gttctacaca tgtatcctgg aacttaaatt 6661 aaaaacaaaa aagagttttt aatccaagaa agattaacag caactagaag aaagaaagag 6721 atataaacag tgaattgcaa tgcagcacgg caggtgttat gatggagtag aaaggactgg 6781 aaaaggcctc ctggaggaag ggacactcaa gtgtctttcc atttcacctg taaactcatt 6841 aagggcaaaa gctttgctac agcttcagta tgagatcctg ggcaatccgt gacaaaatgg 6901 gtctgctttt gcacccccaa cttcttctca catccctgca tcgtgccatg cagcatcaac 6961 tggaaacctc agcgtcagca aacgacgaca gagcgttcat ccgtaaggtg aaccagaaaa 7021 gccagttcaa tgacttgttt aaccatggtc catctcagaa ccaagagttg ggcctcttat 7081 ttaccagaaa aattgtgggg gctttgtgat atggctttaa aaaaatcttg taattgccag 7141 gcgtggtggc tcacacctgt aatcccagca ctttgggagg ccgaggtggg tgaatcgcct 7201 aaggtcagga gttcgagacc agcctgacca acatggtgaa actccgtctc tactaaaaat 7261 acaaaaacta gctggatgtg gtgacgcgtg cctgtaatcc tagctactca ggaggctgac 7321 gcaggagaat cacttgaacc tgggaggcag aggttgcagt gagccaagat tgtgccattg 7381 cgctccaaaa aaaaaaaaaa aatacattaa cataaattta aatattttat aatgacaatc 7441 cacattaact acttaaagca taagctattt tccaggagag gcagcaagtg cattctactc 7501 ccatgcccaa gaaoaaagga gcgtgacttt ggtgggagta ctaggagttt ctactggagc 7561 acttgcccgc agagtgagaa acgttcctag agaggaagtt atacctgctg tggaatttaa 7621 gagaatcttg tcatattttg acaagttttt tgagatggaa gtctcactct gtcgcccagg 7681 ctggagtgca gtggcgcaat ctcagctcac tgcagcctgc acctcctcgg ttccagctat 7741 tctcttgtct cagcctcctg agtaactggg attacaggcg cccgccacta cgcctggcta 7801 atttttgtat ttttagtaga aatggggttt taccatgttg gccagactgg tctcaaactc 7861 ccgacctcag gtgatctgcc tgcctcagcc tcccaaagtg ctggaattac aggcgtgtgc 7921 cactgcgcct ggctaatttt tttttttttt tttttttagt agagacggtg gtttcaccat 7981 gtcatccagg ctggtctcaa actcctgacc tcaggtgatc cacccacctt ggtctaccaa WO 00/09525 1278 PCT/US99/17712 8041 agtgctcgga ttacaggcat gagccaccag gcccagtcaa cgtgatgtgt tttggaaccc 8101 tgaattcctt ggcttgccgg agggttttct ttttgttaat atctttgctt gctttctagt 8161 atttaaaaaa ttgtgttttg ctctaactat gcaatggctt taagtcttag acaaatttcc 8221 agggagcaaa acacactcaa ccaatttcat aataatcaga agagagctct gatcaataaa 8281 taagcaagac tgaattttac aaaataatcc aaagtttaaa accaaagccc actttttqca 8341 tgatccttta agagaaagaa atctggaagc aaaacacctt ataaaatgac aatgcacttt 8401 caggagccca gggcactgtg gtgaaatgat gatggctagt acaggttata agccttgggg 8461 aattatttat gaattctcag gatccttcag ttcgccgcat ccttctccat tatttgaata 8521 ttggaggctg cctgaccaga atcttgtcag gactttgctc cttcatccca ggtggtcccg 8581 gctgactcct gaggacgtta cagccctgag gggaggactc agcttatgaa gtgctgggtg 8641 agaccactgc caagaagtgc ttgctcaccc taccttcaac ggcaggggaa tctccctctc 8701 cttttatggg cgtagctgaa gaaaggattc ataaatgaag ttcaatcctt ctcatcaacc 8761 ccagcccaca cctccagcaa ttgaacttga aaaaaaaaac ctggtttgaa aaattaccgc 8821 aaactatatt gtcatcaaaa aaaaaaaaaa aaaaacactt cctatatttg agatgagaga 8881 agagagtgct aggcagtttc ctggctgaac acgccagccc aatacttaaa gagagcaact 8941 cctgactccg atagagactg gatggaccca caagggtgac agcccaggcg gaccgatctt 9001 cccatcccac atcctccggc gcgatgccaa aaagaggctg acggcaactg ggccttctgc 9061 agagaaagac ctccgcttca ctgccccggc tggtcccaag ggtcaggaag atggattcat 9121 acctgctgat gtggggactg ctcacgttca tcatggtgcc tggctgccag gcaggtaagg 9181 gcctgtgggt gcccccggaa ttc 1 gaattccccc cccccccccc cgagagactg gatggaccca caagggtgac agcccaggcg 61 gaccgatctt cccatcccac atcctccggc gcgatgccaa aaagaggctg acggcaactg 121 ggccttctgc agagaaagac ctccgcttca ctgccccggc tggtcccaag ggtcaggaag 181 atggattcat acctgctgat gtggggactg ctcacgttca tcatggtgcc tggctgccag 241 gcagagctct gtgacgatga cccgccagag atcccacacg ccacattcaa agccatggcc 301 tacaaggaag gaaccatgtt gaactgtgaa tgcaagagag gtttccgcag aataaaaagc 361 gggtcactct atatgctctg tacaggaaac tctagccact cgtcctggga caaccaatgt 421 caatgcacaa gctctgccac tcggaacaca acgaaacaag tgacacctca acctgaagaa 481 cagaaagaaa ggaaaaccac agaaatgcaa agtccaatgc agccagtgga ccaagcgagc 541 cttccaggtc actgcaggga acctccacca tgggaaaatg aagccacaga gagaatttat 601 catttcgtgg tggggcagat ggtttattat cagtgcgtcc agggatacag ggctctacac 661 agaggtcctg ctgagagcgt ctgcaaaatg acccacggga agacaaggtg gacccagccc 721 cagctcatat gcacaggtga aatggagacc agtcagtttc caggtgaaga gaagcctcag 781 gcaagccccg aaggccgtcc tgagagtgag acttcctgcc tcgtcacaac aacagatttt 841 caaatacaga cagaaatggc tgcaaccatg gagacgtcca tatttacaac agagtaccag 901 gtagcagtgg ccggctgtgt tttcctgctg atcagcgtcc tcctcctgag tgggctcacc 961 tggcagcgga gacagaggaa gagtagaaga acaatctaga aaaccaaaag aacaagaatt 1021 tcttggtaag aagccgggaa cagacaacag aagtcatgaa gcccaagtga aatcaaaggt 1081 gctaaatggt cgcccaggag acatccgttg tgcttgcctg cgttttggaa gctctgaagt 1141 cacatcacag gacacggggc agtggcaacc ttgtctctat gccagctcag tcccatcaga 1201 gagcgagcgc tacccacttc taaatagcaa tttcgccgtt gaagaggaag ggcaaaacca 1261 ctagaactct ccatcttatt ttcatgtata tgtgttcatt aaagcatgaa tggtatggaa 1321 ctctctccac cctatatgta gtataaagaa aagtaggttt acattcatct cattccaact 1381 tcccagttca ggagtcccaa ggaaagcccc agcactaacg taaatacaca acacacacac 1441 tctaccctat acaactggac attgtctgcq tggttccttt ctcagccgct tctgactgct 1501 gattctcccg ttcacgttgc ctaataaaca tccttcaaga actctgggct gctacccaga 1561 aatcatttta cccttggctc aatcctctaa gctaaccccc ttctactgag ccttcagtct 1621 tgaatttcta aaaaacagag gccatggcag aataatcttt gggtaacttc aaaacggggc 1681 agccaaaccc atgaggcaat gtcaggaaca gaaggatgaa tgaggtccca ggcagagaat 1741 catacttagc aaagttttac ctgtgcgtta ctaattggcc tctttaagag ttagtttctt 1801 tgggattgct atgaatgata ccctgaattt ggcctgcact aatttgatgt ttacaggtgg 1861 acacacaagg tgcaaatcaa tgcgtacgtt tcctgagaag tgtctaaaaa caccaaaaag 1921 ggatccgtac attcaatgtt tatgcaagga aggaaagaaa gaaggaagtg aagagggaga 1981 agggatggag gtcacactgg tagaacgtaa ccacggaaaa gagcgcatca ggcctggcac 2041 ggtggctcag gcctataacc ccagctccct aggagaccaa ggcgggagca tctcttgagg 2101 ccaggagttt gagaccagcc tgggcagcat agcaagacac atccctacaa aaaattagaa 2161 attggctgga tgtggtggca tacgcctgta gtcctagcca ctcaggaggc tgaggcagga 2221 ggattgcttg agcccagqag ttcgaggctg cagtcagtca tgatggcacc actgcactcc 2281 agcctgggca acagagcaaq atcctgtctt taaggaaaaa aagacaaggg aattc 1 gaattcatgg aaatgggaag ggcagtgatg gagatgggaa gggcagtggg ggttggaggg 61 gtggggattg ttgttgggta cgaaaacaga attagatcga atgaataaga tctagtattt 121 gatagcataa cagggtgact ttagtcaaca ataatttatt gtacatttaa aaataactaa 181 aagagtatac ttggatttta acacaaagaa aggataaata cttgaggtga tggatacccc 241 atttaccctg atgtgattat tatacattgt atgcctgtat caaaatagct catgtgcctc 301 atgaatatag acacctacca catgcccaca aaattaaaaa ctaaaaaaaa cagtcatctc 361 tgaatgctaa acggagtaag gggcttcctg gaaggctggg tgaaatggga gtctcggaaa 421 gatggtgtgt tgcaggCtgg gaggagggtg agacgctggg gtcacctaga gggacctgct 481 tgtgtgaagc ctacgtatta gtgggtatgt gtgtgaccgg atggaggcgt cagaggtgtt WO 00/09525 1279 PCTIUS99/17712 541 gggtagcctg tgtgagttgg cgtgggggtg atgtaggagg ggagagaggg agggcctgcg 601 ttcccttggc tcctgtgtgc agctaggccc ctatttgaca atgtgtgtct gtgtgtgtgt 661 gtgtgtgtgt gtgtgtgtgt gtgtgccgcc cccagcgtag gaggcagatc tttatctggc 721 cctgggtgct tgaggagttt caggctttct cataagcctc gtctccccgc ctctccaccc 781 caggccttgc ccctctatcc tctgcacagg aagtgggctg gctctgggct tttagtcttt 841 gcggccccag cagccagagc tcagcagggc cctggagaga tggccacggt cccagcaccg 901 gggaggactg gagagcgcgc gctgccaccg ccccatgtct cagccaggtg atgtccccct 961 gcctccctcc cggcccctgt ggaccagcca gagggctggg agtgaaagtc acagagaaga 1021 ctttcagctc tgactcagtt cccccagcag tttctgcctg aactcccatc ccccaacttt 1081 gtcttagaat tc 1 gaagagcaag cgccatgttg aagccatcat taccattcac atccctctta ttcctgcagc 61 tgcccctgct gggagtgggg ctgaacacga caattctgac gcccaatggg aatgaagaca 121 ccacagctga tttcttcctg accactatgc ccactgactc cctcagtgtt tccactctgc 181 ccctcccaga ggttcagtgt tttgtgttca atgtcgagta catgaattgc acttggaaca 241 gcagctctga gccccagcct accaacctca ctctgcatta ttggtacaag aactcggata 301 atgataaagt ccagaagtgc agccactatc tattctctga agaaatcact tctggctgtc 361 agttgcaaaa aaaggagatc cacctctacc aaacatttgt tgttcagctc caggacccac 421 gggaacccag gagacaggcc acacagatgc taaaactgca gaatctggtg atcccctggg 481 ctccagagaa cctaacactt cacaaactga gtgaatccca gctagaactg aactggaaca 541 acagattctt gaaccactgt ttggagcact tggtgcagta ccggactgac tgggaccaca 601 gctggactga acaatcagtg gattatagac ataagttctc cttgcctagt gtggatgggc 661 agaaacgcta cacgtttcgt gttcggagcc gctttaaccc actctgtgga agtgctcagc 721 attggagtga atggagccac ccaatccact gggggagcaa tacttcaaaa gagaatcctt 781 tcctgtttgc attggaagcc gtggttatct ctgttggctc catgggattg attatcagcc 841 ttctctgtgt gtatttctgg ctggaacgga cgatgccccg aattcccacc ctgaagaacc 901 tagaggatct tgttactgaa taccacggga acttttcggc ctggagtggt gtgtctaagg 961 gactggctga gagtctgcag ccagactaca gtgaacgact ctgcctcgtc agtgagattc 1021 ccccaaaagg aggggccctt ggggaggggc ctggggcctc cccatgcaac cagcatagcc 1081 cctactgggc ccccccatgt tacaccctaa agcctgaaac ctgaacccca atcctctgac 1141 agaagaaccc cagggtcctg tagccctaag tggtactaac tttccttcat tcaacccacc 1201 tgcgtctcat actcacctca ccccactgtg gctgatttgg aattttgtgc ccccatgtaa 1261 gcaccccttc atttggcatt ccccacttga gaattaccct tttgccccga acatgttttt 1321 cttctccctc agtctggccc ttccttttcg caggattctt cctccctccc tctttccctc 1381 ccttcctctt tccatctacc ctccgattgt tcctgaaccg atgagaaata aagtttctgt 1441 tgataatcat c gagagactgg atggacccac aagggtgaca gcccaggcgg accgatcttc ccatcccaca 61 tcctccggcg cgatgccaaa aagaggctga cggcaactgg gccttctgca gagaaagacc 121 tccgcttcac tgccccggct ggtcccaagg gtcaggaaga tggattcata cctgctgatg 181 tggggactgc tcacgttcat catggtgcct ggctgccagg cagagctctg tgacgatgac 241 ccgccagaga tcccacacgc cacattcaaa gccatggcct acaaggaagg aaccatgttg 301 aactgtgaat gcaagagagg tttccgcaga ataaaaagcg ggtcactcta tatgctctgt 361 acaggaaact ctagccactc gtcctgggac aaccaatgtc aatgcacaag ctctgccact 421 cggaacacaa cgaaacaagt gacacctcaa cctgaagaac agaaagaaag gaaaaccaca 481 gaaatgcaaa gtccaatgca gccagtggac caagcgagcc ttccaggtga agagaagcct 541 caggcaagcc ccgaaggccg tcctgagagt gagacttcct gcctcgtcac aacaacagat 601 tttcaaatac agacagaaat ggcgcaacc atggagacgt ccatatttac aacagagyac 661 caggtagcag tggccggctg tgttttcctg ctgatcagcg tcctcctcct gagtgggctc 721 acctggcagc ggagacagag gaagagtaga agaacaatct agaaaaccaa aagaacaaga 781 atttcttggt aagaagccgg gaacagacaa cagaagtcat gaagcccaag tgaaatcaaa 841 ggtgctaaat ggtcgcccag gagacatccg ttgtgcttgc ctgcgttttg gaagctctga 901 agtcacatca caggacacgg ggcagtggca accttgtctc tatgccagct cagtcccatc 961 agagagcgag cgctacccac ttctaaatag caatttcgcc gttgaagagg aagggcaaaa 1021 ccactagaac tctccatctt attttcatgt atatgtgttc attaaagcat gaatggtatg 1081 gaactctctc caccctatat gtagtataaa gaaaagtagg tttacattca tctcattcca 1141 acttcccagt tcaggagtcc caaggaaagc cccagcacta acgtaaatac acaacacaca 1201 cactctaccc tatacaactg gacattgtct gcgtggttcc tttctcagcc gcttctgact 1261 gctgattctc ccgttcacgt tgcctaataa acatccttca agaactctgg gctgctaccc 1321 agaaatcatt ttacccttgg ctcaatcctc taagctaacc cccttccact gagccttcag 1381 tcttgaattt ctaaaaaaca gaggccatgg cagaataatc tttgggtaac ttcaaaacgg 1441 ggcagccaaa cccatgaggc aatgtcagga acagaaggat gaatgaggtc ccaggcagag 1501 aatcatactt agcaaagttt tacctgtgcg ttactaattg gcctctttaa gagttagttt 1561 ctt gaattctcag gatccttcag ttcgccgcat ccttctccat tatttgaata ttggaggctg 61 cctgaccaga atcttgtcag gactttgctc cttcatccca ggtggtcccg gctgactcct 121 gaggacgtta cagccctgag gggaggactc agccttatga agtgctgggt gagaccactg 181 ccaagaagtg cttgctcacc ctaccttcaa cggcagggga atctccctct ccttttatgg 241 gcgtagtgaa gaaaggattc ataaatgaag ttcaatcctt ctcatcaacc ccagcccaca 301 cctccagcaa ttgaacttga aaaaaaaaac ctggtttgaa aaattaccgc aaactatatt 361 gtcatcaaaa aaaaaaaaaa aaaaacactt cctatatttg agatgagaga agagagtgct 421 aggcagtttc ctggctgaac acgccagccc aatacttaaa gagagcaacc cctgactccg 481 atagagactg gaggaccca caagggtgac agcccaggcg gaccgatctt cccatcccac 541 atcctccggc gcgatgccaa aaagaggctg acggcaactg ggccttctgc agagaaagac WO 00/09525 1280 PCTAJS99/17712 601 ctccgcttca ctgccccggc tggtcccaag ggtcaggaag atggattcat acctgctgat 661 gtggggactg ctcacgttca tcatggtgcc tggctgccag gcaggtaagg gcctgtgggt 721 gcccccggaa ttc 1 gagctctgtg acgatgaccc gccagagatc ccacacgcca cattcaaagc catggcctac 61 aaggaaggaa ccatgttgaa ctgtgaatgc aagagaggtt tccgcagaat aaaaagcggg 121 tcactctata tgctctgtac aggaaactct agccactcgt cctgggacaa ccaatgtcaa 181 tgcacaagct ctgccactcg gaacacaacg aaacaagtga cacctcaacc tgaagaacag 241 aaagaaagga aaaccacaga aatgcaaagt ccaatgcagc cagtggacca agcgagcctt 301 ccaggtcact gcaaggaacc tccaccatgg gaaaatgaag ccacagagag aatttatcat 361 ttcgtggtgg ggcagatggt ttattatcag tgcgtccagg gatacagggc tctacacaga 421 ggtcctgctg agagcgtctg caaaatgacc cacgggaaga caaggtggac ccagccccag 481 ctcatatgca caggtgaaat ggagaccagt cagtttccag gtgaagagaa gcctcaggca 541 agccccgaag gccgtcctga gagtgagact tcctgcctcg tcacaacaac agattttcaa 601 atacagacag aaatggctgc aaccatggag acgtccatat ttacaacaga gtaccaggta 661 gcagtggccg gctgtgtttt cctgctgatc agcgtcctcc tcctgagtgg gctcacctgg 721 cagcagagac agaggaagag tagaagaaca atctag 1 gaattctcag gatccttcag ttcgccgcat ccttctccat tatttgaata ttggaggctg 61 cctgaccaga atcttgtcag gactttgctc cttcatccca ggtggtcccg gctgactcct 121 gaggacgtta cagccctgag ggaggactca gcttatgaag tgctgggtga gaccactgcc 181 aagaagtgct tgctcaccta ccttcaacgg caggggaatc tccctctcct tttatgggcg 241 tagctgaaga aaggattcat aaatgaagtt caatccttct catcacccca gcccaacctc 301 cagcaattga acttgaaaaa aaaaacctgg tttgaaaaat taccgcaaac tatattgtca 361 tcaaaaaaaa aaaaaaaaaa aaacacttcc tatatttgag atgagagaag agagtgctag 421 gcagtttcct ggctgaacac gccagcccaa tacttaaaga gagcaactcc tgactccgat 481 agagactgga tggacccaca agggtgacag cccaggcgga ccgatcttcc catcccacat 541 cctccggcgc gatgccaaaa agaggctgac ggcaactggg ccttctgcag agaaagacct 601 ccgcttcact gccccggctg gtcccaaggg tcaggaagat ggattcatac ctgctgatgt 661 ggggactgct cacgttcatc atggtgcctg gctgccaggc aggtaagggc c (2) INFORMATION FOR SEQ ID NO:111: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 544 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:111: 1 aagcttaata taaacaagtt tcttgtcact gccaccacca cgaccaaaaa aagctaatca 61 atcactatat ataatacata tatatactat atataataaa tatatatact atatataata 121 catatataca ctatatataa tacatatata ctatatatac actatatact atatatacac 181 atatatatta tgaatgtata tatatagtat atatagtata tatactatgt atgtatatat 241 agtatatata gtatatatac tatgtatgat atatagtata tatagtatat atactatgta 301 tgtgtatata tagtatatat agtatatata gtatatatac tatgtatgta tatatatagt 361 atatatagta tatatactgt gtatgtatat atatagtata tatatactat atatgcatac 421 atagtatata tgcatatata ctatatatac tatatattta tatatactat atactatata 481 tactatatac tgtatatata ctatatatgt atgtatacga tatatatata tactatatat 541 gtac (2) INFORMATION FOR SEQ ID NO:112: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 2002 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:112: 1 cagagaagct ctatctcccc tccaggagcc cagctatgaa ctccttctcc acaagcgcct 61 tcggtccagt tgccttctcc ctggggctgc tcctggtgtt gcctgctgcc ttccctgccc 121 cagtaccccc aggagaagat tccaaagatg tagccgcccc acacagacag ccactcacct 181 cttcagaacg aattgacaaa caaattcggt acatcctcga cggcatctca gccctgagaa 241 aggagacatg taacaagagt aacatgtgtg aaagcagcaa agaggcactg gcagaaaaca 301 acctgaacct tccaaagatg gctgaaaaag atggatgctt ccaatctgga ttcaatgagg 361 agacttgcct ggtgaaaatc atcactggtc ttttggagtt tgaggtatac ctagagtacc 421 tccagaacag atttgagagt agtgaggaac aagccagagc tgtgcagatg agtacaaaag 481 tcctgatcca gttcctgcag aaaaaggcaa agaatctaga tgcaataacc acccctgacc 541 caaccacaaa tgccagcctg ctgacgaagc tgcaggcaca gaaccagtgg ctgcaggaca 601 tgacaactca tctcattctg cgcagcttta aggagttcct gcagtccagc ctgagggctc 661 ttcggcaaat gtagcatggg cacctcagat tgttgttgtt aatgggcatt ccttcttctg 721 gtcagaaacc tgtccactgg gcacagaact tatgttgttc tctatggaga actaaaagta 781 tgagcgttag gacactattt taattatttt taatttatta atatttaaat atgtgaagct 841 gagttaattt atgtaagtga tatttatatt ttaagaagta ccacttgaaa cattttatgt 901 attagttttg aaataataat ggaaagtggc tatgcagttt gaatatcctt tgtttcagag 961 ccagatcatt tcttggaaag tgtacgctta cctcaaataa atggctaact tatacatatt 1021 tttaaagaaa tatttatatt gtatttatat aatgtataaa atggttttta taccaataaa 1081 tggcatttta aaaaattcag ca (2) INFORMATION FOR SEQ ID NO:113: WO 00/09525 1281 PCT/US99/17712 (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 113 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:ll3: 1 gaattccggg aacgaaagag aagctctatc tcccctccag gagcccagct atgaactcct 61 tctccacaag cgccttcggt ccagttgcct tctccctggg gctgctcctg gtgttgcctg 121 ctgccttccc tgccccagta cccccaggag aagattccaa agatgtagcc gccccacaca 181 gacagccact cacctcttca gaacgaattg acaaacaaat tcggtacatc ctcgacggca 241 tctcagccct gagaaaggag acatgtaaca agagtaacat gtgtgaaagc agcaaagagg 301 cactggcaga aaacaacctg aaccttccaa agatggctga aaaagatgga tgcttccaat 361 ctggattcaa tgaggagact tgcctggtga aaatcatcac tggtcttttg gagtttgagg 421 tatacctaga gtacctccag aacagatttg agagtagtga ggaacaagcc agagctgtgc 481 agatgagtac aaaagtcctg atccagttcc tgcagaaaaa ggcaaagaat ctagatgcaa 541 taaccacccc tgacccaacc acaaatgcca gcctgctgac gaagctgcag gcacagaacc 601 agtggctgca ggacatgaca actcatctca ttctgcgcag ctttaaggag ttcctgcagt 661 ccagcctgag ggctcttcgg caaatgtagc atgggcacct cagattgttg ttgttaatgg 721 gcattccttc ttctggtcag aaacctgtcc actgggcaca gaacttatgt tgttctctat 781 ggagaactaa aagtatgagc gttaggacac tattttaatt atttttaatt tattaatatt 841 taaatatgtg aagctgagtt aatttatgta agtcatattt atatttttaa gaagtaccac 901 ttgaaacatt ttatgtatta gttttgaaat aataatggaa agtggctatg cagtttgaat 961 atcctttgtt tcagagccag atcatttctt ggaaagtgta ggcttacctc aaataaatgg 1021 ctaacttata catattttta aagaaatatt tatattgtat ttatataatg tataaatggt 1081 ttttatacca ataaatggca ttttaaaaaa ttc (2) INFORMATION FOR SEQ ID NO:114: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 3659 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear )xi)SEQUENCE DESCRIPTION: SEQ ID NO: 114: aagctaata taaacaagtt tcttgtcact gccaccacca cgaccaaaaa aagctaatca 61 atcactatat ataatacata tatatactat atataataaa tatatatact atatataata 121 catatataca ctatatataa tacatatata ctatatatac actatatact atatatacac 181 atatatatta ggaatgtata tatatagtat atatagtata tatactatgt atgtatatat 241 agtatatata gtatatatac tatgtatgat atatagtata tatagtatat atactatgta 301 tgtgtatata tagtatatat agtatatata gtatataac tatgtatgta tatatatagt 361 atatatagta tatatactgt gtatgtatat atatagtata tatatactat atatgcatac 421 atagtatata tgcatatata ctatatatac tatatattta tatatactat atactatata 481 tactatatac tgtatatata ctatatatgt atgtatacga tatatatata tactatatat 541 gtac cagagaagc ctatctcccc tccaggagcc cagctatgta ctccttctcc acaagcgcct 61 tcggtccagt tgccttctcc ctggggctgc tcctggtgta gcctgctgcc ttccctgccc 121 cagtaccccc aggagaagat tccaaagatg tagccgcccc acacagacag ccactcacct 181 cttcagaacg aattgacaaa caaattcggt acatcctcga cggcatctca gccctgagaa 241 aggagacatg taacaagagt aacatgtgtg aaagcagcaa agaggcactg gcagaaaaca 301 acctgaacct tccaaagatg gctgaaaaag atggatgctt ccaatctgga ttcaatgagg 361 agacttgcct ggtgaaaatc atcactggtc ttttggagtt tgaggtatac ctagagtacc 421 tccagaacag atttgagagt agtgaggaac aagccagagc tgtgcagatg agtacaaaag 481 tcctgatcca gttcctgcag aaaaaggcaa agaatctaga tgcaataacc acccctgacc 541 caaccacaaa tgccagcctg ctgacgaagc tgcaggcaca gaaccagtgg ctgcaggaca 601 tgacaactca tctcattctg cgcagcttta aggagttcct gcagtccagc ctgagggctc 661 ttcggcaaat gtagcatggg cacctcagat tgttgttgtt aatgggcatt ccttcttctg 721 gtcagaaacc tgtccactgg gcacagaact tatgttgttc tctatggaga actaaaagta 781 tgagcgttag gacactattt taattatttt taatttatta atatttaaat atgtgaagct 841 gagttaattt atgtaagtga tatttatatt ttaagaagta ccacttgaaa cattttatgt 901 attagttttg aaataataat ggaaagtggc tatgcagttt gaatatcctt tgtttcagag 961 ccagatcatt tcttggaaag tgtacgctta cctcaaataa atggctaact tatacatatt 1021 ttcaaagaaa tatttatatt gtatttatat aatgtataaa atggttttta taccaataaa 1081 tggcatttta aaaaattcag ca 1gaattccggg aacgaaagag aagctctatc tcccctccag gagcccagct atgaactcct 61 tctccacaag cgccttcggt ccagttgcct tctccctggg gctgctcctg gtgttgcctg 121 6rgccttccc tgccccagta cccccaggag aagattccaa agatgtagcc gccccacaca 181 gacagccact cacctcttca gaacgaattg acaaacaaat tcggtacatc ctcgacggca 241 tctcagccct gagaaaggag acatgtaaca agagtaacat gtgtgaaagc agcaaagagg 301 cactggcaga aaacaacctg aaccttccaa agatggctga aaaagatgga tgcttccaat 361 ctggattcaa tgaggagact tgcctggtga aaatcatcac tggtcttttg gagtttgagg 421 tatacctaga gtacctccag aacagatttg agagtagtga ggaacaagcc agagctgtgc 481 agatgagtac aaaagtcctg atccagttcc tgcagaaaaa ggcaaagaat ctagatgcaa 541 taaccacccc tgacccaacc acaaatgcca gcctgctgac gaagctgcag gcacagaacc 601 agtggctgca ggacatgaca actcatctca ttctgcgcag ctttaaggag ttcctgcagt 661 ccagcctgag ggctcttcgg caaatgtagc atgggcacct cagattgttg ttgttaatgg 721 gcattccttc ttctggtcag aaacctgtcc actgggcaca gaacttatgt tgttctctat WO 00/09525 1282 PCT/US99/17712 781 ggagaactaa aagtatgagc gttaggacac tattttaatt atttttaatt tattaatatt 841 taaatatgtg aagctgagtt aatttatgta agtcatattt atatttttaa gaagtaccac 901 ttgaaacatt ttatgtatta gttttgaaat aataatggaa agtggctatg cagtttgaat 961 atcctttgtt tcagagccag atcatttctt ggaaagtgta ggcttacctc aaataaatgg 1021 ctaacttata catattttta aagaaatatt tatattgtat ttatataatg tataaatggt 1081 ttttatacca ataaatggca ttttaaaaaa ttc (2) INFORMATION FOR SEQ ID NO:115: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1194 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:115: 1 ggatcctcct gcaagagaca ccatcctgag gggaagaggg cttctgaacc agcttgaccc 61 aataagaaat tcttgggtgc cgacggggac agcagattca gagcctagag ccgtgcctgc 121 gtccgtagtt tccttctagc ttctttttga tttcaaatca agacttacag ggagagggag 181 cgataaacac aaactctgca agatgccaca aggtcctcct ttgacatccc caacaaagaa 241 ggtgagtagt aatctccccc tttctgccct gaaccaagtg gcttcagtaa gtttcagggc 301 tccaggagac ctgggcatgc aggtgccgat gaaacagtgg tgaagagact cagtggcagt 361 ggcagtgggg agagcactcg cagcacaggc aaacctctgg cacaagagca aagtcctcac 421 tggaggattc ccaagggtca cttgggagag ggcaggcagc agccaacctc ctctaagtgg 481 gctgaagcag gtgaagaaat ggcagaagac gcggtggtgg caaaaaggag tcacacactc 541 cacctggaga cgccttgaag taactgcacg aaatttgagg gtggccaggc agttctacaa 601 cagccgcctc acagggagag ccagaacaca gcaagaactc agatgactgg tagtattacc 661 ttcttcataa tcccaggctt ggggggctgc gatggagtca gaggaaactc agttcagaac 721 atctttggtt tttacaatac aaattaactg gaacgctaaa ttctagcctg ttaatctggt 781 cactgaaaaa aaaaaaattt tttttttttc aaaaaacata gctttagctt attttttttt 841 tctctttgta aaacttcgtg catgacttca gctttactct tgtcaagaca tgccaagtgc 901 tgagtcacta ataaagaaaa aagaagtaaa ggaagagtgg ttctgcttct tagcgctagc 961 ctcaatgacg acctaagctg cacttttccc cctagttgtg tcttgcgatg ctaaaggacg 1021 tcattgcaca atcttaataa ggtttccaat cagccccacc cgctctggcc ccaccctcac 1081 cctccaacaa agatttatca aatgtgggat tttcccatga gtctcaatat tagagtctca 1141 acccccaata aatataggac tggagatgtc tctgaggctc attctgccct cgag (2) INFORMATION FOR SEQ ID NO:116: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 3319 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:116: ggcggtcccc tgttctcccc gctcaggtgc ggcgctgtgg caggaagcca ccccctcggt 61 cggccggtgc gcggggctgt tgcgccatcc gctccggctt tcgtaaccgc accctgggac 121 ggcccagaga cgctccagcg cgagttcctc aaatgttttc ctgcttgcc aggaccgtcc 181 gccgctctga gtcatgtgcg agtgggaagt cgcactgaca ctgagccggg ccagagggag 241 aggagccgag cgcggcgcgg ggccgaggga ctcgcagtgt gtgtagagag ccgggctcct 301 gcggatgggg gctgcccccg gggcctaagc ccgcctgccc gcccaccgcc ccgccccgcc 361 cctgccaccc ctgccgcccg gttcccatta gcctgtccgc ctctgcggga ccatggagtg 421 gtagccgagg aggaagcatg ctggccgcg gctgcgcgct gctggctgcc ctgctggccg 481 cgccgggagc ggcgctggcc ccaaggcgct gccctgcgca ggaggtggca agaggcgtgc 541 tgaccagtct gccaggagac agcgtgactc tgacctgccc gggggtagag ccggaagaca 601 atgccactgt tcactgggtg ctcaggaagc cggctgcagg ctcccacccc agcagatggg 661 ctggcatggg aaggaggctg ctgctgaggt cggtgcagct ccacgactct ggaaactatt 721 catgctaccg ggccggccgc ccagctggga ctgtgcactt gctggtggat gttccccccg 781 aggagcccca gctctcctgc ttccggaaga gccccctcag caatgttgtt tgtgagtggg 841 gtcctcggag caccccatcc ctgacgacaa aggctgtgct cttggtgagg aagtttcaga 901 acagtccggc cgaagacttc caggagccgt gccagtattc ccaggagtcc cagaagttct 961 cctgccagt agcagtcccg gagggagaca gctctttcta catagtgtcc atgtgcgtcg 1021 ccagtagtgt cgggagcaag ttcagcaaaa ctcaaacctt tcagggttgt ggaatcttgc 1081 agcctgatcc gcctgccaac atcacagtca ctgccgtggc cagaaacccc cgctggctca 1141 gtgtcacctg gcaagacccc cactcctgga actcatcttt ctacagacta cggtttgagc 1201 tcagatatcg ggctgaacgg tcaaagacat tcacaacatg gatggtcaag gacctccagc 1261 atcactgtgt catccacgac gcctggagcg gcctgaggca cgtggtgcag cttcgtgccc 1321 aggaggagtt cgggcaaggc gagtggagcg agtggagccc ggaggccatg ggcacgcctt 1381 ggacagaatc caggagtcct ccagctgaga acgaggtgtc cacccccatg caggcactta 1441 ctactaataa agacgatgat aatattctct tcagagattc tgcaaatgcg acaagcctcc 1501 cagtgcaaga ttcttcttca gtaccactgc ccacattcct ggttgctgga gggagcctgg 1561 ccttcggaac gctcctctgc attgccattg ttctgaggtt caagaagacg tggaagctgc 1621 gggctctgaa ggaaggcaag acaagcatgc atccgccgta ctctttgggg cagctggtcc 1681 cggagaggcc tcgacccacc ccagtgcttg ttcctctcat ctccccaccg gtgtccccca 1741 gcagcctggg gtctgacaat acctcgagcc acaaccgacc agatgccagg gacccacgga 1801 gcccttatga catcagcaat acagactact tcttccccag atagctggct gggtggcacc 1861 agcagcctgg accctgtgga tgacaaaaca caaacgggct cagcaaaaga tgcttctcac 1921 tgccatgcca gcttatctca ggggtgtgcg gcctttggct tcacggaaga gccttgcgga WO 00/09525 1283 PCT/US99/17712 1981 aggttctacg ccaggggaaa atcagcctgc tccagctgtt cagctggttg aggtttcaaa 2041 cctccctttc caaatgccca qcttaaaggg gttagagtga acttgggcca ctgtgaagag 2101 aaccatatca agactctttg gacactcaca cggacactca aaagctgggc aggttggtgg 2161 gggcctcggt gtggagaagc ggctggcagc ccacccctca acacctctgc acaagctgca 2221 ccctcaggca ggtgggatgg atttccagcc aaagcctcct ccagccgcca tgctcctggc 2281 ccactgcatc gtttcatctt ccaactcaaa ctcttaaaac ccaagtgccc ttagcaaatt 2341 ctgtttttct aggcctgggg acggctttta cttaaacgcc aaggcctggg ggaagaagct 2401 ctctcctccc tttcttccct acagttcaaa aacagctgag ggtgagtggg tgaataatac 2461 agtatgtcag ggcctggtcg ttttcaacag aattataatt agttcctcat tagcagtttt 2521 gcctaaatgt gaatgatgat cctaggcatt tgctgaatac agaggcaact gcattggctt 2581 tgggttgcag gacctcaggt gagaagcaga ggaaggagag gagaggggca cagggtctct 2641 accatcccct gtagagtggg agctgagtgg gggatcacag cctctgaaaa ccaatgttct 2701 ctcttctcca cctcccacaa aggagagcta gcagcaggga gggcttctgc catttctgag 2761 atcaaaacgg ttttactgca gctttgtttg ttgtcagctg aacctgggta actagggaag 2821 ataatattaa ggaagacaat gtgaaaagaa aaatgagcct ggcaagaatg cgtttaaact 2881 tggtttttaa aaaactgctg actgttttct cttgagaggg tggaatatcc aatattcgct 2941 gtgtcagcat agaagtaact tacttaggtg tgggggaagc accataactt tgtttagccc 3001 aaaaccaagt caagtgaaaa aggaggaaga gaaaaaatat tttcctgcca ggcatggagg 3061 cccacgcact tcgggaggtc gaggcaggag gatcacttga gtccagaagt ttgagatcag 3121 cctgggcaat gtgataaaac cccatctcta caaaaagcat aaaaattagc caagtgtggt 3181 agagtgtgcc tgaagtccca gatacttggg gggctgaggt gggaggatct cttgagcctg 3241 ggaggtcaag gctgcagtga gccgagattg caccactgca ctccagcctg gggtgacaga 3301 gcaagtgaga ccctgtctc (2) INFORMATION FOR SEQ ID NO:117: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 4413 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:117: ggatcctcct gcaagagaca ccatcctgag gggaagaggg cttctgaacc agcttgaccc 61 aataagaaat tcttgggtgc cgacggggac agcagattca gagcctagag ccgtgcctgc 121 gtccgtagtt tccttctagc ttctttttga tttcaaatca agacttacag ggagagggag 181 cgataaacac aaactctgca agatgccaca aggtcctcct ttgacatccc caacaaagaa 241 ggtgagtagt aatctccccc tttctgccct gaaccaagtg gcttcagtaa gtttcagggc 301 tccaggagac ctgggcatgc aggtgccgat gaaacagtgg tgaagagact cagtggcagt 3 t1 ggcagtgggg agagcactcg cagcacaggc aaacctctgg cacaagagca aagtcctcac 421 tggaggattc ccaagggtca cttgggagag ggcaggcagc agccaacctc ctctaagtgg 481 gctgaagcag gtgaagaaat ggcagaagac gcggtggtgg caaaaaggag tcacacactc 541 cacctggaga cgccttgaag taactgcacg aaatttgagg gtggccaggc agttctacaa g01 cagccgcctc acagggagag ccagaacaca gcaagaactc agatgactgg tagtattacc 6 a1 ttcttcataa tcccaggctt ggggggctgc gatggagtca gaggaaactc agttcagaac 721 atctttggtt tttacaaac aaattaactg gaacgctaaa ttctagcctg ttaatctggt 781 cactgaaaaa aaaaaaattt tttttttttc aaaaaacata gctttagctt attttttttt 841 tctctttgta aaacttcgtg catgacttca gctttactct tgtcaagaca tgccaagtgc 901 tgagtcacta ataaagaaaa aagaagtaaa ggaagagtgg ttctgcttct tagcgctagc 981 ctcaatgacg acctaagctg cacttttccc cctagttgtg tcttgcgatg caaaggacg 1021 tcattgcaca atcttaataa ggtttccaat cagccccacc cgctctggcc ccaccctcac 1081 cctccaacaa agatttatca aatgtgggat tttcccatga gtctcaatat tagagtctca 1141 acccccaata aatataggac tggagatgtc tcgaggctc attctgccct cgag 1 ggcggtcccc tgttctcccc gctcaggtgc ggcgctgtgg caggaagcca ccccctcggt 61 cggccggtgc gcggggctgt tgcgccatcc gctccggctt tcgtaaccgc accctgggac 121 ggcccagaga cgctccagcg cgagttcctc aaatgttttc ctgcgttgcc aggaccgtcc 181 gccgctctga gtcatgtgcg agtgggaagt cgcactgaca ctgagccggg ccagagggag 241 aggagccgag cgcggcgcgg ggccgaggga ctcgcagtgt gtgtagagag ccgggctcct 301 gcggatgggg gctgcccccg gggcctgagc ccgcctgccc gcccaccgcc ccgccccgcc 361 cctgccaccc ctgccgcccg gttcccatta gcctgtccgc ctctgcggga ccatggagtg 421 gtagccgagg aggaagcatg ctggccgtcg gctgcgcgct gctggctgcc ctgctggccg 481 cgccgggagc ggcgctggcc ccaaggcgct gccctgcgca ggagcgtgca agaggcgtgc 541 tgaccagtct gccaggagac agcgtgactc tgacctgccc gggggtagag ccggaagaca 801 atgccactqt tcactgggtg ctcaggaagc cggctgcagg ctcccacccc agcagatggg 681 ctggcatggg aaggaggctg ctgctgaggt cggtgcagct ccacgactct ggaaactatt 721 catgctaccg ggccggccgc ccagctggga ctgtgcactt gctggtggat gttccccccg 781 aggagcccca gctctcctgc ttccggaaga gccccctcag caatgttgtt tgtgagtggg 841 gtcctcggag caccccatcc ctgacgacaa aggctgtgct cttggtgagg aagtttcaga 901 acagtccggc cgaagactc caggagccgt gccagtattc ccaggagtcc cagaagttct 981 cctgccagtt agcagtcccg gagggagaca gctctttcta catagtgtcc atgtgcgtcg 1021 ccagtagtgt cgggagcaag ttcagcaaaa ctcaaacctt tcagggttgt ggaatcttgc 1081 agcctgatcc gcctgccaac atcacagtca ctgccgtggc cagaaacccc cgctggctca 1141 gtgtcacctg gcaagacccc cactcctgga actcatcttt ctacagacta cggtttgagc 1201 tcagatatcg ggctgaacgg tcaaagacat tcacaacatg gatggtcaag gacctccagc 1281 atcactgtgt catccacgac gcctggagcg gcctgaggca cgtggtgcag cttcgtgccc 1321 aggaggagtt cgggcaaggc gagtggagcg agtggagccc ggaggccatg ggcacgcctt 1381 ggacagaatc caggagtcct ccagctgaga acgaggtgtc cacccccatg caggcactta WO 00/09525 1284 PCT/US99/17712 1441 ctactaataa agacgatgat aatattcCt tcagagattc tgcaaatgcg acaagcctcc 1501 cagtgcaaga ttcttcttca gcaccactgc ccacattcct ggttgctgga gggagcctgg 1561 ccttcggaac gctcctctgc attgccattg ttctgaggtt caagaagacg tggaagctgc 1621 gggctctgaa ggaaggcaag acaagcatgc atccgccgta ctctttgggg cagctggtcc 1681 cggagaggcc tcgacccacc ccagcgcttg ttcctctcat ctccccaccg gtgtccccca 1741 gcagcctggg gtctgacaat acctcgagcc acaaccgacc agatgccagg gacccacgga 1801 gcccttatga catcagcaat acagactact tcttccccag atagctggct gggtggcacc 1861 agcagcctgg accctgtgga tgacaaaaca caaacgggct cagcaaaaga tgcttctcac 1921 tgccatgcca gcttatctca ggggtgtgcg gcctttggct tcacggaaga gccttgcgga 1981 aggttctacg ccaggggaaa atcagcctgc tccagctgtt cagctggttg aggtttcaaa 2041 cctccctttc caaatgccca gcttaaaggg gttagagtga acttgggcca ctgtgaagag 2101 aaccatatca agactctttg gacactcaca cggacactca aaagctgggc aggttggtgg 2161 gggcctcggt gtggagaagc ggctggcagc ccacccctca acacctctgc acaagctgca 2221 ccctcaggca ggtgggatgg atttccagcc aaagcccc ccagccgcca tgctcctggc 2281 ccactgcatc gtttcatctt ccaactcaaa ctcttaaaac ccaagtgccc ttagcaaatt 2341 ctgtttttct aggcctgggg acggctttta cttaaacgcc aaggcctggg ggaagaagct 2401 ctctcctccc tttcttccct acagttcaaa aacagctgag ggtgagtggg tgaataatac 2461 agtatgtcag ggcctggtcg ttttcaacag aattataatt agttcctcat tagcagttt 2521 gcctaaatgt gaatgatgat cctaggcatt tgctgaatac agaggcaact gcattggctt 2581 tgggttgcag gacctcaggt gagaagcaga ggaaggagag gagaggggca cagggtctct 2641 accatcccct gtagagtggg agctgagtgg gggatcacag cctctgaaaa ccaatgttct 2701 ctcttctcca cctcccacaa aggagagcta gcagcaggga gggcttctgc catttctgag 2761 atcaaaacgg ttttactgca gctttgtttg ttgtcagctg aacctgggta actagggaag 2821 ataatattaa ggaagacaat gtgaaaagaa aaatgagcct ggcaagaatg cgtttaaact 2881 tggtttttaa aaaactgctg actgttttct cttgagaggg tggaatatcc aatattcgct 2941 gcgtcagcat agaagtaact tacttaggtg tgggggaagc accataactt tgtttagccc 3001 aaaaccaagt caagtgaaaa aggaggaaga gaaaaaatat tttcctgcca ggcatggagg 3061 cccacgcact tcgggaggtc gaggcaggag gatcacttga gtccagaagt ttgagatcag 3121 cctgggcaat gtgataaaac cccatctcta caaaaagcat aaaaattagc caagtgtggt 3181 agagtgtgcc agaagtccca gatacttggg gggctgaggt gggaggatct cttgagcctg 3241 ggaggtcaag gctgcagtga gccgagattg caccactgca ctccagcctg gggtgacaga 3301 gcaagtgaga ccctgtctc (2) INFORMATION FOR SEQ ID NO:118: (i( SEQUENCE CHARACTERISTICS: (A) LENGTH: 1533 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:118: atacctaggc actaatttag ttccatatgt actatgtgta cctgaaaagt tgtgtggcaa 61 tcaaattttc acaaatagaa tcctgtttta aaacactaa gaaagtacct actttatcct 121 ttaaacaaga ggtcagcaga ctttttcac aaagggtcag atagtaaaga ttttacacct 181 tttgtacaat acaatctcta tctcatctac ttagctctgc cattgttgca taaaagcagc 241 tgtagatga g acacaaatgg gtgaggctgt attccaaatg aaacgttatt tgcaaaaaca 301 ggtggtaga g aaatttggt cccaaggctt acttgggaaa aaaaaagatc ttttgaaaaa 361 gaaaaaataa atgaataatt tttttaaaaa attgttccct aggtcatagt ttgccagccc 421 ctgccctaaa caaaaattc ttgaatgcct actgtggtgt gtaagatatg agtaaaacc 481 agggatacac agagaacaaa agagaaaaac tgctattctt gtgaaacttg gaagttggag 541 gtaagctatt taaaataaac ccacaataaa gtacttcaca tagtgcagac tgtttcttta 601 aatcaaaact cactccaaac aaccaattga ttcactttgt aagtttgaat ttttgtcttc 661 agattctttt aaagtgggcc cttagtcagg agcggtggct catgcctgta gtcctagcac 721 tttgggaggc tgaggcaggc agatcacttg aggtcaggag ttcgagacaa gcctggccaa 781 catggcgaaa ccccgtctcc actgaaaaca caaaaattag gctggcatag tggcatttgc 841 ctgtagtcct agctactcag gaggctgagg caggagaatt gcttgaacct gggaggtgaa 901 aattgcagtg agccgagatc atgctattgt actccagcct gggcaacaaa gcaagactcg 961 tctcaaaaaa ataaaaatta aaaaaataaa gtagcctcta gcctaagata gcttgagcct 1021 aggtgtgaat ctactgcctt actctgatgt aagcacagta agtgtggggg ctgcagggaa 1081 tatccaggag gaacaataat ttcagaggct ctgtctcttc atgtccttga cctctgctta 1141 cagcagcaat acttttactc agacttcctg tttctggaac ttgccttctt ttttgctgtg 1201 tttatacttc ccttgtctgt ggttagataa gtataaagcc ctagatctaa gcttctctgt 1261 cttcctccct ccctcccttc ctcttactct cattcatttc atacacactg gctcacacat 1321 ctactctctc tctctatctc tctcagaactg acaattctag gtacaacttt tggcatggtt 1381 ttttcttaac ttcaagtcgt ttctggagaa agtggctatg ctcaaaatgg tgagtcattt 1441 6taacttttc ttatggattt tggattatct gtagcatggt ttcaggttat tcagttccct 1501 aagagacctg agtcaggcac tgggtttgag tgc (2) INFORMATION FOR SEQ ID NO:119: (i( SEQUENCE CHARACTERISTICS: (A) LENGTH: 1658 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (0) TOPOLOGY: linear (xi(SEQUENCE DESCRIPTION: SEQ ID NO:119: ctctctctct atctctctca gaagacaa tctaggtaca acttttggca tggttttttc WO 00/09525 1285 PCT/US99/17712 61 tttacttcaa gtcgtttctg gagaaagtgg ctatgctcaa aatggagact tggaagatgc 121 agaactggat gactactcat tctcatgcta tagccagttg gaagtgaatg gatcgcagca 181 ttcactgacc tgtgcttttg aggacccaga tgtcaacacc accaatctgg aatttgaaat 241 atgtggggcc ctcgtggagg taaagtgcct gaatttcagg aaactacaag agatatattt 301 catcgagaca aagaaattct tactgattgg aaagagcaat atatgtgtga aggttggaga 361 aaagagtcta acctgcaaaa aaatagacct aaccactata gttaaacctg aggctccttt 421 tgacctgagt gtcatctatc gggaaggagc caatgacttt gtggtgacat ttaatacatc 481 acacttgcaa aagaagtatg taaaagtttt aatgcatgat gtagcttacc gccaggaaaa 541 ggatgaaaac aaatggacgc atgtgaattt atccagcaca aagctgacac tcctgcagag 601 aaagctccaa ccggcagcaa tgtatgagat taaagttcga tccatccctg atcactattt 661 taaaggcttc tggagtgaat ggagtccaag ttattacttc agaactccag agatcaataa 721 tagctcaggg gagatggatc ctatcttact aaccatcagc attttgagtt ttttctctgt 781 cgctctgttg gtcatcttgg cctgtgtgtt atggaaaaaa aggattaagc ctatcgtatg 841 gcccagtctc cccgatcata agaagactct ggaacatctt tgtaagaaac caagaaaaaa 901 tttaaatgtg agtttcaatc ctgaaagttt cctggactgc cagattcata gggtggatga 961 cattcaagct agagatgaag tggaaggttt tctgcaagat acgtttcctc agcaactaga 1021 agaatctgag aagcagaggc ttggagggga tgtgcagagc cccaactgcc catctgagga 1081 tgtagtcgtc actccagaaa gctttggaag agattcatcc ctcacatgcc tggctgggaa 1141 tgtcagtgca tgtgacgccc ctattctctc ctcttccagg tccctagact gcagggagag 1201 tggcaagaat gggcctcatg tgtaccagga cctcctgctt agccttggga ctacaaacag 1261 cacgctgccc cctccatttt ctctccaatc tggaatcctg acattgaacc cagttgctca 1321 gggtcagccc attcttactt ccctgggatc aaatcaagaa gaagcatatg tcaccatgtc 1381 cagcttctac caaaaccagt gaagtgtaag aaacccagac tgaacttacc gtgagcgaca 1441 aagatgattt aaaagggaag tctagagttc ctagtctccc tcacagcaca gagaagacaa 1501 aattagcaaa accccactac acagtctgca agattctgaa acattgcttt gaccactctt 1561 cctgagttca gtggcactca acatgagtca agagcatcct gcttctacca tgtggatttg 1621 gtcacaaggt ttaaggtgac ccaatgattc agctattt (2) INFORMATION FOR SEQ ID NO:120: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 3191 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:120: 1 atacctaggc actaatttag ttccatatgt actzatgtgta cctgaaaagt tgtgtggcaa 61 tcaaattttc acaaatagaa tcctgtttta aatacactaa gaaagtacct actttatcct 121 ttaaacaaga ggtcagcaga ctttttctac aaagggtcag atagtaaaga ttttacacct 181 tttgtacaat acaatctcta tctcatctac ttagctctgc cattgttgca taaaagcagc 241 tgtagatgat acacaaatgg gtgaggctgt attccaaatg aaacgttatt tgcaaaaaca 301 ggtggtagat taaatttggt cccaaggctt acttgggaaa aaaaaagatc ttttgaaaaa 361 gaaaaaataa atgaataatt tttttaaaaa attgttccct aggtcatagt ttgccagccc 421 ctgccctaaa caaataattc ttgaatgcct actgtggtgt gtaagatatg agtaaatacc 481 agggatacac agagaacaaa agagaaaaac tgctattctt gtgaaacttg gaagttggag 541 gtaagctatt taaaataaac ccacaataaa gtacttcaca tagtgcagac tgtttcttta 601 aatcaaaact cactccaaac aaccaattga ttcactttgt aagtttgaat ttttgtcttc 661 agattctttt aaagtgggcc cttagtcagg agcggtggct catgcctgta gtcctagcac 721 tttgggaggc tgaggcaggc agatcacttg aggtcaggag ttcgagacaa gcctggccaa 781 catggcgaaa ccccgtctcc actgaaaaca caaaaattag gctggcatag tggcatttgc 841 ctgtagtcct agctactcag gaggctgagg caggagaatt gcttgaacct gggaggtgaa 901 aattgcagtg agccgagatc atgctattgt actccagcct gggcaacaaa gcaagactcg 961 tctcaaaaaa ataaaaatta aaaaaataaa gtagcctcta gcctaagata gcttgagcct 1021 aggtgtgaat ctactgcctt actctgatgt aagcacagta agtgtggggg ctgcagggaa 1081 tatccaggag gaacaataat ttcagaggct ctgtctcttc atgtccttga cctctgctta 1141 cagcagcaat acttttactc agacttcctg tttctggaac ttgccttctt ttttgctgtg 1201 tttatacttc ccttgtctgt ggttagataa gtataaagcc ctagatctaa gcttctctgt 1261 cttcctccct ccctcccttc ctcttactct cattcatttc atacacactg gctcacacat 1321 ctactctctc tctctatctc tctcagaatg acaattctag gtacaacttt tggcatggtt 1381 ttttctttac ttcaagtcgt ttctggagaa agtggctatg ctcaaaatgg tgagtcattt 1441 ctaacttttc ttatggattt tggattatct gtagcatggt ttcaggttat tcagttccct 1501 aagagacctg agtcaggcac tgggtttgag tgc 1 ctctctctct atctctctca gaatgacaat tctaggtaca acttttggca tggttttttc 61 tttacttcaa gtcgtttctg gagaaagtgg ctatgctcaa aatggagact tggaagatgc 121 agaactggat gactactcat tctcatgcta tagccagttg gaagtgaatg gatcgcagca 181 ttcactgacc tgtgcttttg aggacccaga tgtcaacacc accaatctgg aatttgaaat 241 atgtggggcc ctcgtggagg taaagtgcct gaatttcagg aaactacaag agatatattt 301 catcgagaca aagaaattct tactgattgg aaagagcaat atatgtgtga aggttggaga 361 aaagagtcta acctgcaaaa aaatagacct aaccactata gttaaacctg aggctccttt 421 tgacctgagt gtcatctatc gggaaggagc caatgacttt gtggtgacat ttaatacatc 481 acacttgcaa aagaagtatg taaaagtttt aatgcatgat gtagcttacc gccaggaaaa 541 ggatgaaaac aaatggacgc atgtgaattt atccagcaca aagctgacac tcctgcagag 601 aaagctccaa ccggcagcaa tgtatgagat taaagttcga tccatccctg atcactattt 661 taaaggcttc tggagtgaat ggagtccaag ttattacttc agaactccag agatcaataa 721 tagctcaggg gagatggatc ctatcttact aaccatcagc attttgagtt ttttctctgt 781 cgctctgttg gtcatcttgg cctgtgtgtt atggaaaaaa aggattaagc ctatcgtatg WO 00/09525 1286 PCT/US99/17712 841 gcccagtctc cccgatcata agaagactct ggaacatctt tgtaagaaac caagaaaaaa 901 tttaaatgtg agtttcaatc ctgaaagttt cctggactgc cagattcata gggtggatga 961 cattcaagct agagatgaag tggaaggttt tctgcaagat acgtttcctc agcaactaga 1021 agaatctgag aagcagaggc ttggagggga tgtgcagagc cccaactgcc catctgagga 1081 tgtagtcgtc actccagaaa gctttggaag agattcatcc ctcacatgcc tggctgggaa 1141 tgtcagtgca tgtgacgccc ctattctctc ctcttccagg tccctagact gcagggagag 1201 tggcaagaat gggcctcatg tgtaccagga cctcctgctt agccttggga ctacaaacag 1261 cacgctgccc cctccatttt ctctccaatc tggaatcctg acattgaacc cagttgctca 1321 gggtcagccc attcttactt ccctgggatc aaatcaagaa gaagcatatg tcaccatgtc 1381 cagcttctac caaaaccagt gaagtgtaag aaacccagac tgaacttacc gtgagcgaca 1441 aagatgattt aaaagggaag tctagagttc ctagtctccc tcacagcaca gagaagacaa 1501 aattagcaaa accccactac acagtctgca agattctgaa acattgcttt gaccactctt 1561 cctgagttca gtggcactca acatgagtca agagcatcct gcttctacca tgtggatttg 1621 gtcacaaggt ttaaggtgac ccaatgattc agctattt (2) INFORMATION FOR SEQ ID NO:121: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1846 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:121: 1 ctcagcctcg ctatggctcc cagcagcccc cggcccgcgc tgcccgcact cctggtcctg 61 ctcggggctc tgttcccagg acctggcaat gcccagacat ctgtgtcccc ctcaaaagtc 121 atcctgcccc ggggaggctc cgtgctggtg acatgcagca cctcctgtga ccagcccaag 181 ttgttgggca tagagacccc gttgcctaaa aaggagttgc tcctgcctgg gaacaaccgg 241 aaggtgtatg aactgagcaa tgtgcaagaa gatagccaac caatgtgcta ttcaaactgc 301 cctgatgggc agtcaacagc taaaaccttc ctcaccgtgt actggacicc agaacgggtg 361 gaactggcac ccctcccctc ttggcagcca gtgggcaaga accttaccct acgctgccag 421 gtggagggtg gggcaccccg ggccaacctc accgtggtgc tgctccgtgg ggagaaggag 481 ctgaaacggg agccagctgt gggggagccc gctgaggtca cgaccacggt gctggtgagg 541 agagatcacc atggagccaa tttctcgtgc cgcactgaac tggacctgcg gccccaaggg 601 ctggagctgt ttgagaacac ctcggccccc taccagctcc agacctttgt cctgccagcg 661 actcccccac aacttgtcag cccccgggtc ctagaggtgg acacgcaggg gaccgtggtc 721 tgttccctgg acgggctgtt cccagtctcg gaggcccagg tccacctggc actgggggac 781 cagaggttga accccacagt cacctatggc aacgactcct tctcggccaa ggcctcagtc 841 agtgtgaccg cagaggacga gggcacccag cggctgacgt gtgcagtaat actggggaac 901 cagagccagg agacactgca qacagtgacc atctacagct ttccggcgcc caacgtgatt 961 ctgacgaagc cagaggtctc agaagggacc gaggtgacag tgaagtgtga ggcccaccct 1021 agagccaagg tgacgctgaa tggggttcca gcccagccac tgggcccgag gqcccagctc 1081 ctgctgaagg ccaccccaga ggacaacggg cgcagcttct cctgctctgc aaccctggag 1141 gtggccggcc agcttataca caagaaccag acccgggagc ttcgtgtcct gtatggcccc 1201 cgactggacg agagggattg tccgggaaac tggacgtggc cagaaaattc ccagcagact 1261 ccaatgtgcc aggcttgggg gaacccattg cccgagctca agtgtctaaa ggatggcact 1321 ttcccactgc ccatcgggga atcagtgact gtcactcgag atcttgaggg cacctacctc 1381 tgtcgggcca ggagcactca aggggaggtc acccgcgagg tgaccgtgaa tgtgctctcc 1441 ccccggtatg agattgtcat catcactgtg gtagcagccg cagtcataat gggcactgca 1501 ggcctcagca cgtacctcta taaccgccag cggaagatca agaaatacag actacaacag 1561 gcccaaaaag ggacccccat gaaaccgaac acacaagcca cgcctccctg aacctatccc 1621 gggacagggc ctcttcctcg gccttcccat attggtggca gtggtgccac actgaacaga 1681 gtggaagaca tatgccatgc agctacacct accggccctg ggacgccgga ggacagggca 1741 ttgtcctcag tcagatacaa cagcatttgg ggccatggta cctgcacacc taaaacacta 1801 ggccacgcat ctgatctgta gtcacatgac taagccaaga ggaagg (2) INFORMATION FOR SEQ ID NO:122: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1041 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:122: ctaaagatct ccctccaggc agcccttggc tggtccctgc gagcccgtgg agactgccag 61 agatggcctc tttcggttac aggaccctga ctgtggccct cttcaccctg atctgctgtc 121 caggatcgga tgagaaggta ttcgaggtac acgtgaggcc aaagaagctg gcggttgagc 181 ccaaagggtc cctcgaggtc aactgcagca ccacctgtaa ccagcctgaa gtgggtggtc 241 tggagacctc tctaaataag attctgctgg acgaacaggc tcagtggaaa cattacttgg 301 tctcaaacat ctcccatgac acggtcctcc aatgccactt cacctgctcc gggaagcagg 361 agtcaatgaa ttccaacgtc agcgtgtacc agcctccaag gcaggtcatc ctgacactgc 421 aacccacttt ggtggctgtg ggcaagtcct tcaccattga gtgcagggtg cccaccgtgg 481 agcccctgga cagcctcacc ctcttcctgt tccgtggcaa tgagactctg cactatgaga 541 ccttcgggaa ggcagcccct gctccgcagg aggccacagc cacattcaac agcacggctg 601 acagagagga tggccaccgc aacttctcct gcctggctgt gctggacttg atgtctcgcg 661 gtggcaacat ctttcacaaa cactcagccc cgaagatgtt ggagatctat gagcctgtgt 721 cggacagcca gatggtcatc atagtcacgg tggtgtcggt gttgctgtcc ctgttcgtga 781 catctgtcct gctctgcttc atcttcggcc agcacttgcg ccagcagcgg atgggcacct WO 00/09525 1287 PCT/US99/17712 841 acggggtgcg agcggcttgg aggaggctgc cccaggcctt ccggccatag caaccatgag 901 tggcatggcc accaccacgg tggtcactgg aactcagtgt gactcctcag ggttgaggtc 961 cagccctggc tgaaggactg tgacaggcag cagagacttg ggacattgcc ttttctagcc 1021 cgaatacaaa cacctggact t (2) INFORMATION FOR SEQ ID NO:123: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 2887 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:123: 1 ctcagcctcg ctatggctcc cagcagcccc cggcccgcgc tgcccgcact cctggtcctg 61 ctcggggctc tgttcccagg acctggcaat gcccagacat ctgtgtcccc ctcaaaagtc 121 atcctgcccc ggggaggctc cgtgctggtg acatgcagca cctcctgtga ccagcccaag 181 ttgttgggca tagagacccc gttgcctaaa aaggagttgc tcctgcctgg gaacaaccgg 241 aaggtgtatg aactgagcaa tgtgcaagaa gatagccaac caatgtgcta ttcaaactgc 301 cctgatgggc agtcaacagc taaaaccttc ctcaccgtgt actggactcc agaacgggtg 361 gaactggcac ccctcccctc ttggcagcca gtgggcaaga accttaccct acgctgccag 421 gtggagggtg gggcaccccg ggccaacctc accgtggtgc tgctccgtgg ggagaaggag 481 ctgaaacggg agccagctgt gggggagccc gctgaggtca cgaccacggt gctggtgagg 541 agagatcacc atggagccaa tttctcgtgc cgcactgaac tggacctgcg gccccaaggg 601 ctggagctgt ttgagaacac ctcggccccc taccagctcc agacctttgt cctgccagcg 661 actcccccac aacttgtcag cccccgggtc ctagaggtgg acacgcaggg gaccgtggtc 721 tgttccctgg acgggctgtt cccagtctcg gaggcccagg tccacctggc actgggggac 781 cagaggttga accccacagt cacctatggc aacgactcct tctcggccaa ggcctcagtc 841 agtgtgaccg cagaggacga gggcacccag cggctgacgt gtgcagtaat actggggaac 901 cagagccagg agacactgca gacagtgacc atctacagct ttccggcgcc caacgtgatt 961 ctgacgaagc cagaggtctc agaagggacc gaggtgacag tgaagtgtga ggcccaccct 1021 agagccaagg tgacgctgaa tggggttcca gcccagccac tgggcccgag ggcccagctc 1081 ctgctgaagg ccaccccaga ggacaacggg cgcagcttct cctgctctgc aaccctggag 1141 gtggccggcc agcttataca caagaaccag acccgggagc ttcgtgtcct gtatggcccc 1201 cgactggacg agagggattg tccgggaaac tggacgtggc cagaaaattc ccagcagact 1261 ccaatgtgcc aggcttgggg gaacccattg cccgagctca agtgtctaaa ggatggcact 1321 ttcccactgc ccatcgggga atcagtgact gtcactcgag atcttgaggg cacctacctc 1381 tgtcgggcca ggagcactca aggggaggtc acccgcgagg tgaccgtgaa tgtgctctcc 1441 ccccggtatg agattgtcat catcactgtg gtagcagccg cagtcataat gggcactgca 1501 ggcctcagca cgtacctcta taaccgccag cggaagatca agaaatacag actacaacag 1561 gcccaaaaag ggacccccat gaaaccgaac acacaagcca cgcctccctg aacctatccc 1621 gggacagggc ctcttcctcg gccttcccat attggtggca gtggtgccac actgaacaga 1681 gtggaagaca tatgccatgc agctacacct accggccctg ggacgccgga ggacagggca 1741 ttgtcctcag tcagatacaa cagcatttgg ggccatggta cctgcacacc taaaacacta 1801 ggccacgcat ctgatctgta gtcacatgac taagccaaga ggaagg 1 ctaaagatct ccctccaggc agcccttggc tggtccctgc gagcccgtgg agactgccag 61 agaagtcctc tttcggttac aggaccctga ctgtggccct cttcaccctg atctgctgtc 121 caggatcgga tgagaaggta ttcgaggtac acgtgaggcc aaagaagctg gcggttgagc 181 ccaaagggtc cctcgaggtc aactgcagca ccacctgtaa ccagcctgaa gtgggtggtc 241 tggagacctc tctaaataag attctgctgg acgaacaggc tcagtggaaa cattacttgg 301 tctcaaacat ctcccatgac acggtcctcc aatgccactt cacctgctcc gggaagcagg 361 agtcaatgaa ttccaacgtc agcgtgtacc agcctccaag gcaggtcatc ctgacactgc 421 aacccacttt ggggctgtg ggcaagtcct tcaccattga gtgcagggtg cccaccgtgg 481 agcccctgga cagcctcacc ctcttcctgt tccgtggcaa tgagactctg cactatgaga 541 ccttcgggaa ggcagcccct gctccgcagg aggccacagc cacattcaac agcacggctg 601 acagagagga tggccaccgc aacttctcct gcctggctgt gctggacttg atgtctcgcg 661 gtggcaacat ctttcacaaa cactcagccc cgaagatgtt ggagatctat gagcctgtgt 721 cggacagcca gatggtcatc atagtcacgg tggtgtcggt gttgctgtcc ctgttcgtga 781 catctgtcct gctctgcttc atcttcggcc agcacttgcg ccagcagcgg atgggcacct 841 acggggtgcg agcggcttgg aggaggctgc cccaggcctt ccggccatag caaccatgag 901 tggcatggcc accaccacgg tggtcactgg aactcagtgt gactcctcag ggttgaggtc 961 cagccctggc tgaaggactg tgacaggcag cagagacttg ggacattgcc ttttctagcc 1021 cgaatacaaa cacctggact t (2) INFORMATION FOR SEQ ID NO:124: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1739 base pairs (c) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:124: 1 aatggccacc atggtaccat ccgtgttgtg gcccagggcc tgctggactc tgctggtctg 61 ctgtctgctg accccaggtg tccaggggca ggagttcctt ttgcgggtgg agccccagaa 121 ccctgtgctc tctgctggag ggtccctgtt tgtgaactgc agtactgatt gtcccagctt 181 tgagaaaatc gccttggaga cgtccctatc aaaggagctg gtggccagtg gcatgggctg 241 ggcagccttc aatctcagca acgtgactgg caacagtcgg atcctctgct cagtgtactg 301 caatggctcc cagataacag gctcctctaa catcaccgtg tacgggctcc cggagcgtgt WO 00/09525 1288 PCT/US99/17712 361 ggagctggca cccctgcctc cttggcagcc ggggccag aacttcaccc tgcgctgcca 421 agtggagggt gggtcgcccc ggaccagcct cacggtggtg ctgcttcgct gggaggagga 481 gctgagccgg cagcccgcag tggaggagcc agcggaggtc actgccactg tgctggccag 541 cagagacgac cacggagccc ctttctcatg ccgcacagaa ctggacatgc agccccaggg 601 gctgggactg ttcgtgaaca cctcagcccc ccgccagctc cgaacctttg tcctgcccgt 661 gacccccccg cgcctcgtgg ccccccggtt cttggaggtg gaaacgtcgt ggccggtgga 721 ctgcacccta gacgggcttt ttccagcctc agaggcccag gtctacctgg cgctggggga 781 ccagatgctg aatgcgacag tcatgaacca cggggacacg ctaacggcca cagccacagc 841 cacggcgcgc gcggatcagg agggtgcccg ggagatcgtc tgcaacgtga ccctaggggg 901 cgagagacgg gaggcccggg agaacttgac ggtctttagc ttcctaggac ccattgtgaa 961 cctcagcgag cccaccgccc atgaggggtc cacagtgacc gtgagttgca tggctggggc 1021 tcgagtccag gtcacgctgg acggagttcc ggccgcggcc ccggggcagc cagctcaact 1081 tcagctaaat gctaccgaga gtgacgacgg acgcagcttc ttctgcagtg ccactctcga 1141 ggtggacggc gagttcttgc acaggaacag tagcgtccag ctgcgagtcc tgtatggtcc 1201 caaaattgac cgagccacat gcccccagca cttgaaatgg aaagataaaa cgagacacgt 1261 gctgcagtgc caagccaggg gcaacccgta ccccgagctg cggtgtttga aggaaggctc 1321 cagccgggag gtgccggtgg ggatcccgtt cttcgtcaac gtaacacata atggtactta 1381 tcagtgccaa gcgtccagct cacgaggcaa atacaccctg gtcgtggtga tggacattga 1441 ggctgggagc tcccactttg tccccgtctt cgtggcggtg ttactgaccc tgggcgtggt 1501 gactatcgta ctggccttaa tgtacgtctt cagggagcac caacggagcg gcagttacca 1561 tgttagggag gagagcacct atctgcccct cacgtctatg cagccgacag aagcaatggg 1621 ggaagaaccg tccagagctg agtgacgctg ggatccggga tcaaagttgg cgggggcttg 1681 gctgtgccct cagattccgc accaataaag ccttcaaacc ctaaaaaaaa aaaaaaaaa (2) INFORMATION FOR SEQ ID NO:125: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 920 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:125: 1gcacggaggg gcagagaccc cggagcccca gccccaccat gaccctcggc cgccgactcg 61 cgtgtctttt cctcgcctgt gtcctgccgg ccttgctgct ggggggcacc gcgctggcct 121 cggagattgt ggggggccgg cgagcgcggc cccacgcgtg gcccttcatg gtgtccctgc 181 agctgcgcgg aggccacttc tgcggcgcca ccctgattgc gcccaacttc gtcatgtcgg 241 ccgcgcactg cgtggcgaat gtaaacgtcc gcgcggtgcg ggtggtcctg ggagcccata 301 acctctcgcg gcgggagccc acccggcagg tgttcgccgt gcagcgcatc ttcgaaaacg 361 gctacgaccc cgtaaacttg ctcaacgaca tcgtgattct ccagctcaac gggtcggcca 421 ccatcaacgc caacgtgcag gtggcccagc tgccggctca gggacgccgc ctgggcaacg 481 gggtgcagtg cctggccatg ggctggggcc ttctgggcag gaaccgtggg atcgccagcg 541 tcctgcagga gctcaacgtg acggtggtga cgtccctctg ccgtcgcagc aacgtctgca 601 ctctcgtgag gggccggcag gccggcgtct gtttcgggga ctccggcagc cccttggtct 661 gcaacgggct aatccacgga attgcctcct tcgtccgggg aggctgcgcc tcagggctct 721 accccgatgc ctttgccccg gtggcacagt ttgtaaactg gatcgactct atcatccaac 781 gctccgagga caacccctgt ccccaccccc gggacccgga cccggccagc aggacccact 841 gagaagggct gcccgggtca cctcagctgc ccacacccac actctccagc atctggcaca 901 ataaacattc ccgttttgt (2) INFORMATION FOR SEQ ID NO:126: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 5292 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:126: 1ttgtcagagc cccagctggt gtccagggac tgaccgtgag cctgggtgaa agtgagttcc 61 ccgttggagg caccagacga ggagaggatg gaaggcctgg cccccaagaa tgagccctga 121 ggttcaggag cggctggagt gagccgcccc cagatctccg tccagctgcg ggtcccagag 181 gcctgggtta cactcggagc tcctggggga ggcccttgac gtgctcagtt cccaaacagg 241 aaccctggga aggaccagag aagtgcctat tgcgcagtga gtgcccgaca cagctgcatg 301 tggccggtat cacagggccc tgggtaaact gaggcaggcg acacagctgc atgtggccgg 361 tatcacaggg ccctgggtaa actgaggcag gcgacacagc tgcatgtggc cggtatcaca 421 gggccctggg taaactgagg caggcgacac agctgcatgt ggccggtatc acagggccct 481 gggtaaactg aggcaggcga cacagctgca tgtggccggt atcacggggc cctggataaa 541 cagaggcagg cgaggccacc cccatcaagt ccctcaggtc taggtttggc caggtttgga 601 aaaacacagc aacgctcggt aaatctgaat ttcgggtaag tatatcctgg gcctcatttg 661 gaagagactt agattaaaaa aaaaacgtcg agaccagccc ggccaacacg tgaaaccccg 721 tctctactaa aaatacaaaa aattagccag gcgcagtgct cacgcctgtg atcccagcac 781 tctgggaggt gaggcaggcg gatcacccga ggtcagctgt tcaagaccag cctggccgag 841 tgggcgaaac actgtctcta ctacaaatac aaaaattagc cgggagtgga ggcaggtgcc 901 tgtaatctca gctattcagg aggctgaggc aggagaatca cttgaacctg ggaggcggag 961 gttgccgtga gccgggatca cgccaccgca ctccagcctg ggcgatagag caagactctg 1021 tctccaaaaa aataaattaa aaaacccaca ttgattatct gacatttgaa tgcgattgtg 1081 catcctgaat tttatctgga ggccccaccc gagccaatcc agcgtcttgt cccccttctc 1141 ccccttttca tcaacgcctg tgccagggga gaggaagtgg agggcgctgg ccggccgtgg WO 00/09525 1289 PCT/US99/17712 1201 ggcaatgcaa cggcctccca gcacagggct ataagaggag ccgggcgggc acggaggggc 1261 agagaccccg gagccccagc dccaccatga ccctcggcdg ccgactcgcg tgtcttttcc 1321 tcgcctgt t cct ccggcc ttctgctgq ggggtgagtt tttggtpa acctcccgct 1381 6c ttcc c gi 1441 tcabdta Cagag tgccag tg gacaaggaga agadgag Qtga4#td' 1501 gactfa& ggdac a a ggagqccaga gttggggttt gaaaccggI g g~ggggg 1561 gtggcaggtc qfgctggg ttcaagtcca ggtctgtctg tgccttggag gggcaccg 1621 gggabgt~cd tttgctc~c cgtgcctczag tttcctcatc tga~c~acag g~gfgcgaac 1681 ggcccdgdtc ctqt'ggttr ccggtggggg atccagaggc cccgtggqcg ggaggggaca 1741 ggctc(.ttgg g~ggqactc4 gCaQccgcac cqgqtgtgtc ccc~ggc~pg gqgctggqFt 181cg -tt qqg~c cgagcgcggc cccacgcgtg gccct~tCatg gtgtccctgc 1801 cgg' , gg 1861 agqtg64cgg agdcacttc tgcggcgcca ccctgattgc gcccaacttc qtcatgtcgg 1921 bcgcgcactq cgtggcgaat gtgtgagtag ccgggagtgt gcgcgcccgg ctcggacccc 1981 qcgtcccggt ctgtqaggtg ggtgggggga ggccggggcc ggggctgctg gcgggggggg 2041 gtccgtccag ggcccqcggg gcccctcgag caccttcgcc ctcaggcccg tcgccggatg 2101 gggacgacaa ggcgcggctg agccccgacc cccggggccg cccctgagcc ccgcctctcc 2161 ctcttttggc agaaactcc gcgcggtgcg ggtggtcctg ggagcccata acctctcgcg 2221 gcgggagccc acccggcagg tgttcgccgt gcagcgcatc ttcgaaaacg gctacgaccc 2281 cgtaaacttg ctcaacgaca tcgtgattct ccaggtgccg ccgggcgggc gggggcgagg 2341 ggcggaggcc agaggcctgg ggagggtgga ggcctgggga gggtggaggc tgcgacggag 2401 gggcgcgtcg gggccgctcg tggggacctg gggtggcatc gtgggctggg tggtcccctc 2461 ccgcgcctc ggtctgcacc tctgtgaaac gggaaaatac ccgccatggg ccgttgaggg 2521 gttaaatgag atcctgcagg gaggccccga tctgctgtca atcaacaaac ttactgagaa 2581 gggaggcccc gatctgttgt caatcaacaa acttactgag aagggaggcc ccgatctgtt 2641 gtcaatcaac aaacttactg agaagggagg ccccgatctg ctgtcaatca acaaacttac 2701 tgagaaggga ggccccgatg ttgtcaatca acaaacttac tgagaaggga ggccccgatc 2761 tgctgtcaat caaccaaact tactgagaag ggaggccccg atctgctgtc aatcatcaaa 2821 cttactgaga agggaggccc cgatctgctg tcaatcaaca aacttactga gaagggaggc 2881 ccccgatctg ttgtcaatca acaaacttac tgagaaggga ggccccgatc tgctgtcaat 2941 caacaaactt actgagattc tgtgtgtctc tccattcacc agtcctgtgg cccagggcag 3001 gggccgcctc tgtctttggg aaaaggggca aaagtcccca cctttccacc cctgtccgcg 3061 gcttgcagtt ctggttattt cctgggcgcc gggccccgtg gctcaggcct gtcatcccag 3121 cactttggga ggctgaggcg ggtggatcac gaggtcaggt gttcgagacc agcctgagca 3181 acatagtgaa accccgtctc tactaaaata cacaaaaaaa aaattagccg agtgtggttg 3241 tgggtgcctg taatgccaac tactcaggag gctgaggaag gagaatcgct tgaaccccgg 3301 aggcggagat tgcagtgagc tgagatcaca ccactgcact ccagcctggg tctcaaaaaa 3361 aaaaaaaaag attcctccct gggaagggtt agagggagag tttccttgtc actaagtttt 3421 ctcatagctc tcacccagtg cagtggcgcg atcgcagctc actacacctc catctcctgg 3481 gctcaagcca ccctctcagc ttggaatggg gggtagctgg aaccacaggt gccaccacgt 3541 ggtccaccac gtctggctaa tatatatata tacacacaca catacatata ttataaataa 3601 taaatatata ttttatttaa ataaaatata taatatttat aattatttta taattataat 3661 aatatttata taattataaa tatcatttat aattataata tttattattt tataaaataa 3721 taaatataaa atatataaaa atatttttat aaataataaa atatatatat acacacatat 3781 atatatattt tttgagacaa gtctcgctct gtcgcccagg ctggagcgca gtgcacaatc 3841 tcactcactg cacctccgcc tcccaggttc aagcgattct cctgcctcag cctcccaggt 3901 agctgggact acaggcgccc gccaccacgc ctggctaatt tttggtattg ttagtagaga 3961 cggggtttaa ccatgttagc caggatggtc ttgatctcct gaccttttga ttggcccacc 4021 tcagcctccc aaaatgctgg gattataggc gtgagcaccg cacctggcaa ttttttttta 4081 ttatttttgt agacatgggg ctttgccaca ttgcccaggc tggtcttgaa tgcctggcct 4141 ggcctaagtg atcctcctgc ctcgccctcc caaagtgctg ggcttacaag catgagccac 4201 cgcgcccggc tgtagttttt ttgttaactg agcacctact gcttcctgca ctcaagccac 4261 atccagggac aacctccaac gccctgagcc ttggtgacgg ctcccactct acagatgggg 4321 aaaccgaggc ttgccttggg gagcagagtg tggggtgggt atcctgccct gcaggatccc 4381 agaaccacag tggaacctga gatggggaaa ctgaggcccg gagaggggag ggtcatcatc 4441 actgccccgt gtgacgcgct gacgatctgt ccccaccgcc acagctcaac gggtcggcca 4501 ccatcaacgc caacgtgcag gtggcccagc tgccggctca gggacgccgc ctgggcaacg 4561 gggtgcagtg cctggccatg ggctggggcc ttctgggcag gaaccgtggg atcgccagcg 4621 tcctgcagga gctcaacgtg acggtggtga cgtccctctg ccgtcgcagc aacgtctgca 4681 ctctcgtgag gggccggcag gccggcgtct gtttcgtacg tgccctgggt gtccctctgc 4741 tccccacccg ctcccagccc ggtactgcag caacaggcac cgtggctaga ccctaggatg 4801 ggacttccca accctgacac gtcggcgggc aggtgggcag ggcctcgcag tccagcttcc 4861 ccaccttgtc tgcctccaca gggggactcc ggcagcccct tggtctgcaa cgggctaatc 4921 cacggaattg cctccttcgt ccggggaggc tgcgcctcag ggctctaccc cgatgccttt 4981 gccccggtgg cacagtttgt aaactggatc gactctatca tccaacgctc cgaggacaac 5041 ccctgtcccc acccccggga cccggacccg gccagcagga cccactgaga agggctgccc 5101 gggtcacctc agctgcccac acccacactc tccagcatct ggcacaataa acattctctg 5161 ttttgtagaa tgtgtttgat gctccttggc tgtgtgattg ggtgttgaaa atggtcagta 5221 ggtcgggcgt ggtggctcac acctgtaatc ccagcacttt gggaggttga ggcaggcgga 5281 tcacttgagc tc (2) INFORMATION FOR SEQ ID NO:127: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 6212 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single WO 00/09525 1290 PCT/US99/17712 (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:127: 1 gcacggaggg gcagagaccc cggagcccca gccccaccat gaccctcggc cgccgactcg 61 cgtgtctttt cctcgcctgt gtcctgccgg ccttgctgct ggggggcacc gcgctggcct 121 cggagattgt ggggggccgg cgagcgcggc cccacgcgtg gcccttcatg gtgtccctgc 181 agctgcgcgg aggccacttc tgcggcgcca ccctgattgc gcccaacttc gtcatgtcgg 241 ccgcgcactg cgtggcgaat gtaaacgtcc gcgcggtgcg ggtggtcctg ggagcccata 301 acctctcgcg gcgggagccc acccggcagg tgttcgccgt gcagcgcatc ttcgaaaacg 361 gctacgaccc cgtaaacttg ctcaacgaca tcgtgattct ccagctcaac gggtcggcca 421 ccatcaacgc caacgtgcag gtggcccagc tgccggctca gggacgccgc ctgggcaacg 481 gggtgcagtg cctggccatg ggctggggcc ttctgggcag gaaccgtggg atcgccagcg 541 tcctgcagga gctcaacgtg acggtggtga cgtccctctg ccgtcgcagc aacgtctgca 601 ctctcgtgag gggccggcag gccggcgtct gtttcgggga ctccggcagc cccttggtct 661 gcaacgggct aatccacgga attgcctcct tcgtccgggg aggctgcgcc tcagggctct 721 accccgatgc ctttgccccg gtggcacagt ttgtaaactg gatcgactct atcatccaac 781 gctccgagga caacccctgt ccccaccccc gggacccgga cccggccagc aggacccact 841 gagaagggct gcccgggtca cctcagctgc ccacacccac actctccagc atctggcaca 901 ataaacattc tctgttttgt 1 ttgtcagagc cccagctggt gtccagggac tgaccgtgag cctgggtgaa agtgagttcc 61 ccgttggagg caccagacga ggagaggatg gaaggcctgg cccccaagaa tgagccctga 121 ggttcaggag cggctggagt gagccgcccc cagatctccg tccagctgcg ggtcccagag 181 gcctgggtta cactcggagc tcctggggga ggcccttgac gtgctcagtt cccaaacagg 241 aaccctggga aggaccagag aagtgcctat tgcgcagtga gtgcccgaca cagctgcatg 301 tggccggtat cacagggccc tgggtaaact gaggcaggcg acacagctgc atgtggccgg 361 tatcacaggg ccctgggtaa actgaggcaa gcgacacagc tgcatgtggc cggtatcaca 421 gggccctggg taaactgagg caggcgacac agctgcatgt ggccggtatc acagggccct 481 gggtaaactg aggcaggcga cacagctgca tgtggccggt atcacggggc cctggataaa 541 cagaggcagg cgaggccacc cccatcaagt ccctcaggtc taggtttggc caggtttgga 601 aaaacacagc aacgctcggt aaatctgaat ttcgggtaag tatatcctgg gcctcatttg 661 gaagagactt agattaaaaa aaaaacgtcg agaccagccc ggccaacacg tgaaaccccg 721 tctctactaa aaatacaaaa aattagccag gcgcagtgct cacgcctgtg atcccagcac 781 tctgggaggt gaggcaggcg gatcacccga ggtcagctgt tcaagaccag cctggccgag 841 tgggcgaaac actgtctcta ctacaaatac aaaaattagc cgggagtgga ggcaggtgcc 901 tgtaatctca gctattcagg aggctgaggc aggagaatca cttgaacctg ggaggcggag 961 gttgccgtga gccgggatca cgccaccgca ctccagcctg ggcgatagag caagactctg 1021 tctccaaaaa aataaattaa aaaacccaca ttgattatct gacatttgaa tgcgattgtg 1081 catcctgaat tttgtctgga ggccccaccc gagccaatcc agcgtcttgt cccccttctc 1141 ccccttttca tcaacgcctg tgccagggga gaggaagtgg agggcgctgg ccggccgtgg 1201 ggcaatgcaa cggcctccca gcacagggct ataagaggag ccgggcgggc acggaggggc 1261 agagaccccg gagccccagc cccaccatga ccctcggccg ccgactcgcg tgtcttttcc 1321 tcgcctgtgt cctgccggcc ttgctgctgg ggggtgagtt tttgagtcca acctcccgct 1381 gctccctctg tcccgggttc tgttcccacc tctccataga gggccccacc agtgtgggtc 1441 cctcatcctc acaggggagg tgccagctgg gacaaggaga ccagaagaga ctgaggttct 1501 gagcggtgaa gccaccacca ggagcccaga gttggggttt gaaaaccggg gagggggggg 1561 gtggcaggtc gccctctggg ttcaagtcca ggtctgtctg tgccttggag gggcaccgtg 1621 gggaggtccc tttgcctctc cgtgcctcag tttcctcatc tgaacaacag gggtgcgaac 1681 ggccccgatc ccgtgggttc ccggtggggg atccagaggc cccgtggccg ggaggggaca 1741 ggctccttgg caggcactca gcacccgcac ccggtgtgtc cccaggcacc gcgctggcct 1801 cggagattgt ggggggccgg cgagcgcggc cccacgcgtg gcccttcatg gtgtccctgc 1861 agctgcgcgg aggccacttc tgcggcgcca ccctgattgc gcccaacttc gtcatgtcgg 1921 ccgcgcactg cgtggcgaat gtgtgagtag ccgggagtgt gcgcgcccgg ctcggacccc 1981 gcgtcccggt ctgtgaggtg ggtgggggga ggccggggcc ggggctgctg gcgggggggg 2041 gtccgtccag ggcccgcggg gcccctcgag caccttcgcc ctcaggcccg tcgccggatg 2101 gggacgacaa ggcgcggctg agccccgacc cccggggccg cccctgagcc ccgcctctcc 2161 ctcttttggc agaaacgtcc gcgcggtgcg ggtggtcctg ggagcccata acctctcgcg 2221 gcgggagccc acccggcagg tgttcgccgt gcagcgcatc ttcgaaaacg gctacgaccc 2281 cgtaaacttg ctcaacgaca tcgtgattct ccaggtgccg ccgggcgggc gggggcgagg 2341 ggcggaggcc agaggcctgg ggagggtgga ggcctgggga gggtggaggc tgcgacggag 2401 gggcgcgtcg gggccgctcg tggggacctg gggtggcatc gtgggctggg tggtcccctc 2461 tccgcgcctc ggtctgcacc tctgtgaaac gggaaaatac ccgccatggg ccgttgaggg 2521 gttaaatgag atcctgcagg gaggccccga tctgctgtca atcaacaaac ttactgagaa 2581 gggaggcccc gatctgttgt caatcaacaa acttactgag aagggaggcc ccgatctgtt 2641 gtcaatcaac aaacttactg agaagggagg ccccgatctg ctgtcaatca acaaacttac 2701 tgagaaggga ggccccgatg ttgtcaatca acaaacttac tgagaaggga ggccccgatc 2761'tgctgtcaat caaccaaact tactgagaag ggaggccccg atctgctgtc aatcatcaaa 2821 cttactgaga agggaggccc cgatctgctg tcaatcaaca aacttactga gaagggaggc 2881 ccccgatctg ttgtcaatca acaaacttac tgagaaggga ggccccgatc tgctgtcaat 2941 caacaaactt actgagattc tgtgtgtctc tccattcacc agtcctgtgg cccagggcag 3001 gggccgcctc tgtctttggg aaaaggggca aaagtcccca cctttccacc cctgtccgcg 3061 gcttgcagtt ctggttattt cctgggcgcc gggccccgtg gctcaggcct gtcatcccag 3121 cactttggga ggctgaggcg ggtggatcac gaggtcaggt gttcgagacc agcctgagca 3181 acatagtgaa accccgtctc tactaaaata cacaaaaaaa aaattagccg agtgtggttg 3241 tgggtgcctg taatgccaac tactcaggag gctgaggaag gagaatcgct tgaaccccgg 3301 aggcggagat tgcagtgagc tgagatcaca ccactgcact ccagcctggg tctcaaaaaa 3361 aaaaaaaaag attcctccct gggaagggtt agagggagag tttccttgtc actaagtttt WO 00/09525 1291 PCT/US99/17712 3421 ctcatagctc tcacccagtg cagtggcgcg atcgcagctc actacacctc catctcctgg 3481 gctcaagcca ccctctcagc ttggaatagg gggtagctqg aaccacaggt gccaccacgt 3541 ggtccaccac gtctggctaa tatatatata tacacacaca catacatata ttataaataa 3601 taaatatata ttttatttaa ataaaatata taatatttat aattatttta taattataat 3661 aatatttata taattataaa tatcatttat aattataata tttattattt tataaaataa 3721 taaatataaa atatataaaa atatttttat aaataataaa atatatatat acacacatat 3781 atatatattt tttgagacaa gtctcgctct gtcgcccagg ctggagcgca gtgcacaatc 3841 tcactcactg cacctccgcc tcccaggttc aagcgattct cctgcctcag cctcccaggt 3901 agctgggact acaggcgccc gccaccacgc ctggctaatt tttggtattg ttagtagaga 3961 cggggtttaa ccatgttagc caggatggtc ttgatctcct gaccttttga ttggcccacc 4021 tcagcctccc aaaatgctgg gattataggc gtgagcaccg cacctggcaa ttttttttta 4081 ttatttttgt agacatgggg ctttgccaca ttgcccaggc tggtcttgaa tgcctggcct 4141 ggcctaagtg atcctcctgc ctcgccctcc caaagtgctg ggcttacaag catgagccac 4201 cgcgcccggc tgtagttttt ttgttaactg agcacctact gcttcctgca ctcaagccac 4261 atccagggac aacctccaac gccctgagcc ttggtgacgg ctcccactct acagatgggg 4321 aaaccgaggc ttgccttggg gagcagagtg tggggtgggt atcctgccct gcaggatccc 4381 agaaccacag tggaacctga gatggggaaa ctgaggcccg gagaggggag ggtcatcatc 4441 actgccccgt gtgacgcgct gacgatctgt ccccaccgcc acagctcaac gggtcggcca 4501 ccatcaacgc caacgtgcag gtggcccagc tgccggctca gggacgccgc ctgggcaacg 4561 gggtgcagtg cctggccatg ggctggggcc ttctgggcag gaaccgtggg atcgccagcg 4621 tcctgcagga gctcaacgtg acggtggtga cgtccctctg ccgtcgcagc aacgtctgca 4681 ctctcgtgag gggccggcag gccggcgtct gtttcgtacg tgccctgggt gtccctctgc 4741 tccccacccg ctcccagccc ggtactgcag caacaggcac cgtggctaga ccctaggatg 4801 ggacttccca accctgacac gtcggcgggc aggtgggcag ggcctcgcag tccagcttcc 4861 ccaccttgtc tgcctccaca gggggactcc ggcagcccct tggtctgcaa cgggctaatc 4921 cacggaattg cctccttcgt ccggggaggc tgcgcctcag ggctctaccc cgatgccttt 4981 gccccggtgg cacagtttgt aaactggatc gactctatca tccaacgctc cgaggacaac 5041 ccctgtcccc acccccggga cccggacccg gccagcagga cccactgaga agggctgccc 5101 gggtcacctc agctgcccac acccacactc tccagcatct ggcacaataa acattctctg 5161 ttttgtagaa tcgtgtccgat gctccttggc tgtgtgatg ggtgttgaaa atggtcagta 5221 ggtcgggcgc ggtgctcac acctgtaatc ccagcacttt gggaggttga ggcaggcgga 5281 tcacttgagc tc (2) INFORMATION FOR SEQ ID NO:128: (1) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1755 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:128: 1 ctattgcagt atctttcagc ttccagtctt atctgaagac cccggcacca aagtgaccag 61 gaggcagaga agaacttcag aggagtctcg tcttgggctg cccgtgggtg agtgggaggg 121 tccgggactg cagaccggtg gcgatggcca ctctcccagc agcagaaacc tggatagacg 181 ggggtggagg cgtgggtgca gacgccgtga acctgaccgc ctcgctagct gccggggcgg 241 ccacgggggc agttgagact gggtggctgc aactgctgga ccaagctggc aacctctcct 301 cccccccttc cgcgctggga ctgcctgtgg cttcccccgc gccctcccag ccctgggcca 361 acctcaccaa ccagtcgtg cagccgtcct ggcgcatcgc gctctggtcc ctggcgtatg 421 gtgtggggt ggcagtggca gttttgggaa atctcatcgt catctggatc accctggccc 481 acaagcgcat gaggactgtc accaactact tccttgtgaa cctggctttc tccgacgcct 541 ccatggccgc cttcaacacg ttggtcaatt tcatctacgc gcttcatagc gagtggtact 601 ttggcgccaa ctactgccgc ttccagaact tctttcctat cacagctgtg ttcgccagca 661 tctactccat gacggccatt gcggtggaca ggtatatggc tattatigat cccttgaaac 721 ccagactgtc tgctacagca accaagattg tcattggaag tatttggatt ctagcatttc 781 tacttgcctg ccctcagtgt ctttattcca aaaccaaagt catgccaggc cgtactctct 841 gcttgtgca atggccagaa ggtcccaaac aacatttcac ttaccatatt atcgtcatta 901 tactggtgta ctgtttccca ttgctcatca tgggtattac atacaccatt gttggaatta 961 ctctctgggg aggagaaatc ccaggagata cctgtgacaa gtatcatgag cagctaaagg 1021 ccaaaagaaa ggttgtcaaa atgatgatta ttgttgtcat gacatttgct atctgctggc 1081 tccctatca tatttacttc attctcactg caatcatca acaactaaat agatggaaat 1141 acatccagca ggtctaccag gctagctttt ggctggcaat gagctcaacc atgtacaatc 1201 ccatcatcta ctgcatctg aataaaagat ttcgagctgg cttcaagaga gcatttcgct 1261 ggtgtccttt catcaaagtt tccagctatg atgagctaga gctcaagacc accaggtttc 1321 atccaaaccg gcaaagcagt atgtacaccg tgaccagaat ggagtccatg acagtcgtgt 1381 ttgaccccaa cgatgcagac accaccaggt ccagtcggaa gaaaagagca acgccaagag 1441 acccaagttt caatggctgc tctcgcagga attccaaatc tgcctccgcc acttcaagtt 1501 tcataagctc accctatacc tctgtggatg aatattctta attccatttc ctgaggtaaa 1561 agattagtgt gagaccatca tgggccagt ctaggacccc attctcctat ttatcagtcc 1621 tgtcctatat accctctaga aacagaaagc aattttagg cagctatggt caaattgaga 1681 aaggtagtgt ataaatgtga caaagacact aataacatgt tagcctccac ccaaaataaa 1741 atgggcttta aattt (2) INFORMATION FOR SEQ ID NO:129: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 600 base pairs (t) TYPE: nucleic acid WO 00/09525 1292 PCTIUS99/17712 (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:129: 1 ctgcagaccg gtggcgatgg ccatcctccc agcagcagaa acctggatag acgggggtgg 61 aggcgtgggt gcagacgccg tgaacctgac cgcctcgcta gctgccgggg cggccacggg 121 ggcagttgag actgggtggc tgcaactgct ggaccaagct ggcaacctct cctcctcccc 181 ttccgcgctg ggactgcctg tgcgttcccc cgcgccctcc cagccctggg ccaacctcac 241 caaccagttc gtgcagccgt cctggcgtat cgcgctctgg tccctggcgt atggtgtggt 301 ggtggcagtg gcagttttgg gaaatctcat cgtcatctgg atcatcctgg cccacaagcg 361 catgaggact gtcaccaact acttccttgt gaacctggct ttctccgacg cctccatggc 421 cgccttcaac acgttggtca atttcatcta cgcgcttcat agcgagtggt actttggcgc 481 caactactgc cgcttccaga acttctttcc tatcacagct gtgttcgcca gcatctactc 541 catgacggcc attgcggtgg acaggtgagg agaggacaga cagagaggaa agagggagaa (2) INFORMATION FOR SEQ ID NO:130: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 227 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:130: 1 ggtatatggc tattattgat cccttgaaac ccagactgtc tgctacagca accaagattg 61 tcattggaag tatttggatt ctagcatttc tacttgcctt ccctcagtgt ctttattcca 121 aaaccaaagt catgccaggc cgtactctct gctttgtgca atggccagaa ggtcccaaac 181 aacatttcac gtaagttaat tctctattat ggttttcaat tcagttt (2) INFORMATION FOR SEQ ID NO:131: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 201 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:131: 1 catgtgtttt tcttattttt catagttacc atattatcgt cattatactg gtgtactgtt 61 tcccattgct catcatgggt attacataca ccattgttgg aattactctc tggggaggag 121 aaatcccagg agatacctgt gacaagtatc atgagcagct aaaggccaaa agaaaggtac 181 tggtccatgt tgtttaccta g (2) INFORMATION FOR SEQ ID NO:132: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 255 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:132: 1 caaatgactt tttctttata ggttgtcaaa atgatgatta ttgttgtcat gacatttgct 61 atctgctggc tgccctatca tatttacttc attctcactg caatctatca acaactaaat 121 agatggaaat acatccagca ggtctacctg gctagctttt ggctggcaat gagctcaacc 181 atgtacaatc ccatcatcta ctgctgtctg aataaaaggt aaaaacaaaa ctacgaaatg 241 caagttgctt gtcac (2) INFORMATION FOR SEQ ID NO:133: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 449 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:133: 1 aaaataactt ttctttctgt ggcctgcttt tcctcagatt tcgagctggc ttcaagagag 61 catttcgctg gtgtcctttc atcaaagttt ccagctatga tgagctagag ctcaagacca 121 ccaggtttca tccaaaccgg caaagcagta tgtacaccgt gaccagaatg gagtccatga 181 cagtcgtgtt tgaccccaac gatgcagaca ccaccaggtc cagtcggaag aaaagagcaa 241 cgccaagaga cccaagtttc aatggctgct ctcgcaggaa ttccaaatct gcctccgcca 301 cttcaagttt cataagctca ccctatacct ctgtggatga atattcttaa ttccatttcc 361 tgaggtaaaa gattagtgtg agaccatcat ggtgccagtc taggacccca ttctcctatt 421 tatcagtcct gtcctatata ccctctaga (2) INFORMATION FOR SEQ ID NO:134: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 3128 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single WO 00/09525 1293 PCT/US99/17712 (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:134: 1 ctgcagaccg gtggcgatgg ccatcctccc agcagcagaa acctggatag acgggggtgg 61 aggcgtgggt gcagacgccg tgaacctgac cgcctcgcta gctgccgggg cggccacggg 121 ggcagttgag actgggtggc tgcaactgct ggaccaagct ggcaacctct cctcctcccc 181 ttccgcgctg ggactgcctg tgcgttcccc cgcgccctcc cagccctggg ccaacctcac 241 caaccagttc gtgcagccgt cctggcgtat cgcgctctgg tccctggcgt atggtgtggt 301 ggtggcagtg gcagttttgg gaaatctcat cgtcatctgg atcatcctgg cccacaagcg 361 catgaggact gtcaccaact acttccttat gaacctggct ttctccgacg cctccatggc 421 cgccttcaac acgttggtca atttcatcra cgcgcttcat agcgagtggt actttggcgc 481 caactactgc cgcttccaga acttctttcc tatcacagct gtgttcgcca gcatctactc 541 catgacggcc attgcggtgg acaggtgagg agaggacaga cagagaggaa agagggagaa 1 ctattgcagt atctttcagc ttccagtctt atctgaagac cccggcacca aagtgaccag 61 gaggcagaga agaacttcag aggagtctcg tcttgggctg cccgtgggtg agtgggaggg 121 tccgggactg cagaccggtg gcgatggcca ctctcccagc agcagaaacc tggatagacg 181 ggggtggagg cgtgggtgca gacgccgtga acctgaccgc ctcgctagct gccggggcgg 241 ccacgggggc agttgagact gggtggctgc aactgctgga ccaagctggc aacctctcct 301 cctccccttc cgcgctggga ctgcctgtgg cttcccccgc gccctcccag ccctgggcca 361 acctcaccaa ccagttcgtg cagccgtcct ggcgcatcgc gctctggtcc ctggcgtatg 421 gtgtggtggt ggcagtggca gttttgggaa atctcatcgt catctggatc atcctggccc 481 acaagcgcat gaggactgtc accaactact tccttgtgaa cctggctttc tccgacgcct 541 ccatggccgc cttcaacacg ttggtcaatt tcatctacgc gcttcatagc gagtggtact 601 ttggcgccaa ctactgccgc ttccagaact tctttcctat cacagctgtg ttcgccagca 661 tctactccat gacggccatt gcggtggaca ggtatatggc tattattgat cccttgaaac 721 ccagactgtc tgctacagca accaagattg tcattggaag tatttggatt ctagcatttc 781 tacttgcctt ccctcagtgt ctttattcca aaaccaaagt catgccaggc cgtactctct 841 gctttgtgca atggccagaa ggtcccaaac aacatttcac ttaccatatt atcgtcatta 901 tactggtgta ctgtttccca ttgctcatca tgggtattac atacaccatt gttggaatta 961 ctctctgggg aggagaaatc ccaggagata cctgtgacaa gtatcatgag cagctaaagg 1021 ccaaaagaaa ggttgtcaaa atgatgatta ttgttgtcat gacatttgct atctgctggc 1081 tgccctatca tatttacttc attctcactg caatctatca acaactaaat agatggaaat 1141 acatccagca ggtctacctg gctagctttt ggctggcaat gagctcaacc atgtacaatc 1201 ccatcatcta ctgctgtctg aataaaagat ttcgagctgg cttcaagaga gcatttcgct 1261 ggtgtccttt catcaaagtt tccagctatg atgagctaga gctcaagacc accaggtttc 1321 atccaaaccg gcaaagcagt atgtacaccg tgaccagaat ggagtccatg acagtcgtgt 1381 ttgaccccaa cgatgcagac accaccaggt ccagtcggaa gaaaagagca acgccaagag 1441 acccaagttt caatggctgc tctcgcagga attccaaatc tgcctccgcc acttcaagtt 1501 tcataagctc accctatacc tctgtggatg aatattctta attccatttc ctgaggtaaa 1561 agattagtgt gagaccatca tggtgccagt ctaggacccc attctcctat ttatcagtcc 1621 tgtcctatat accctctaga aacagaaagc aatttttagg cagctatggt caaattgaga 1681 aaggtagtgt ataaatgtga caaagacact aataacatgt tagcctccac ccaaaataaa 1741 atgggcttta aattt 1 ggtatatggc tattattgat cccttgaaac ccagactgtc tgctacagca accaagattg 61 tcattggaag tatttggatt ctagcatttc tacttgcctt ccctcagtgt ctttattcca 121 aaaccaaagt catgccaggc cgtactctct gctttgtgca atggccagaa ggtcccaaac 181 aacatttcac gtaagttaat tctctattat ggttttcaat tcagttt 1 catgtgtttt tcttattttt catagttacc aattatcgt cattatactg gtgtactgtt 61 tcccattgct catcatgggt attacataca ccattgttgg aattactctc tggggaggag 121 aaatcccagg agatacctgt gacaagtatc atgagcagct aaaggccaaa agaaaggtac 181 tggtccatgt tgtttaccta g 1 caaatgactt tttctttata ggttgtcaaa atgatgatta ttgttgtcat gacatttgct 61 atctgctggc tgccctatca tatttacttc attctcactg caatctatca acaactaaat 121 agatggaaat acatccagca ggtctacctg gctagctttt ggctggcaat gagctcaacc 181 atgtacaatc ccatcatcta ctgctgtctg aataaaaggt aaaaacaaaa ctacgaaatg 241 caagttgctt gtcac 1 aaaataactt ttctttctgt ggcctgcttt tcctcagatt tcgagctggc ttcaagagag 61 catttcgctg gtgtcctttc atcaaagttt ccagctatga tgagctagag ctcaagacca 121 ccaggtttca tccaaaccgg caaagcagta tgtacaccgt gaccagaatg gagtccatga 181 cagtcgtgtt tgaccccaac gatgcagaca ccaccaggtc cagtcggaag aaaagagcaa 241 cgccaagaga cccaagtttc aatggctgct ctcgcaggaa ttccaaatct gcctccgcca 301 cttcaagttt cataagctca ccctatacct ctgtggatga atattcttaa ttccatttcc 361 tgaggtaaaa gattagtgtg agaccatcat ggtgccagtc taggacccca ttctcctatt 421 tatcagtcct gtcctatata ccctctaga (2) INFORMATION FOR SEQ ID NO:135: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 2206 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:135: 1 ctagtctttc agccttcagg ctgtttttgg cttgaagctc tcttggcctc ctagtttcta 61 cctaatcatg tccctggtgg aggccatcag cctctggaac gaaggggtgc tggcagcgga WO 00/09525 1294 PCT/US99/17712 121 caagaaggac tggaagggag ccctggatgc cttcagtgcc gtccaggacc cccactcccg 181 gatttgcttc aacattggct gcatgtacac tatcctgaag aacatgactg aagcagagaa 241 ggcctttacc agaagcatta accgagacaa gcacttggca gtggcttact tccaacgagg 301 gatgctctac taccagacag agaaatatga tttggctatc aaagacctta aagaagcctt 361 gattcagctt cgagggaacc agctgataga ctataagatc ctggggctcc agttcaagct 421 gttgcctgt gaggtgttat ataacattgc tttcatgtat gccaagaagg aggaatggaa 481 aaaagctgaa gaacagttag cattggccac gagcatgaag tctgagccca gacattccaa 541 aatcgacaag gcgatggagt gtgtctggaa gcagaagcta tatgagccag tggtgatccc 601 tgtgggcaag ctgtttcgac caaatgagag acaagtggct cagctggcca agaaggatta 661 cctaggcaag gcgacggtcg tggcatctgt ggtggatcaa gacagtttct ctgggtttgc 721 ccctctgcaa ccacaggcag ctgagcctcc acccagaccg aaaaccccag agatcttcag 781 ggctcggaa ggggaggctc accgtgtgct atttgggttt gtgcctgaga caaaagaaga 841 gctccaggtc atgccaggga acattgtctt tgtcttgaag aagggcaatg ataactgggc 901 cacggtcatg ttcaacgggc agaaggggct tgttccctgc aactaccttg aaccagttga 961 gttgcggatc caccctcagc agcagcccca ggaggaaagc tctccgcagt ccgacatccc 1021 agctcctcct agttccaaag cccctggaaa accccagctg tcaccaggcc agaaacaaaa 1081 agaagagcct aaggaagtga agctcagtgt tcccatgccc tacacactca aggtgcacta 1141 caagtacacg gtagtcatga agactcagcc cgggctcccc tacagccagg tccgggacat 1201 ggtgtctaag aaactggagc tccggctgga acacactaag ctgagctatc ggcctcggga 1261 cagcaatgag ctggtgcccc tttcagaaga cagcatgaag gatgcctggg gccaggtgaa 1321 aaactactgc ctgactctgt ggtgtgagaa cacagtgggt gaccaaggct ttccagatga 1381 acccaaggaa agtgaaaaag ctgatgctaa taaccagaca acagaacctc agcttaagaa 1441 aggcagccaa gtggaggcac tcttcagtta tgaggctacc caaccagagg acctggagtt 1501 tcaggaaggg gatataatcc tggtgttatc aaaggtgaat gaagaatggc tggaagggga 1561 gtgcaaaggg aaggtgggca ttttccccaa agtttttgtt gaagactgcg caactacaga 1621 tttggaaagc actcggagag aagtctagga tgtttcacaa actacaaagc tgaagaaaat 1681 gaagccctat tacttgtttg taagatttag cacccttctg ctgtatactg tactgagaca 1741 ttacagtttg gaagtgttaa ctatttattc cctgttaaaa tttaacctac tagacaatga 1801 tgtgagtacc caggatgatt tcctggggca cagtgggtga ggagatgggg acaggtgaat 1861 ggaggagtta ggggagagga aaagtggatg gaagtgtctg gaaagggcac gagagagtct 1921 tccaggtact gatcctgttt cttgctctga gtgctagcta gccagctgtg ttcacactgt 1981 aaacattcat caagctgtac atttggtgca cttttctgtg tcataccaca ataaaaaaaa 2041 acctatcatc atcttacaaa aacaagacac ccaagtccag gcccaaggag taagtacaaa 2101 tattcctgtt tctgaaccat tactgtaatt ggctcttaag gcttgaagta accttatagg 2161 ttactcataa ggcatataca aataaacttg tttgttttct tttttc (2) INFORMATION FOR SEQ ID NO:136: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1739 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:136: 1 ctagtctttc agccttcagg ctgtttttgg cttgaagctc tcttggcctc ctagtttcta 61 cctaatcatg tccctggtgg aggccatcag cctctggaat gaaggggtgc tggcagcgga 121 caagaaggac tggaagggag ccctggatgc cttcagtgcc gtccaggacc cccactcccg 181 gatttgcttc aacattggct gcatgtacac tatcctgaag aacatgactg aagcagagaa 241 ggcctttacc agaagcatta accgagacaa gcacttggca gtggcttact tccaacgagg 301 gatgctctac taccagacag agaaatatga tttggctatc aaagacctta aagaagcctt 361 gattcagctt cgagggaacc agctgataga ctataagatc ctggggctcc agttcaagct 421 gtttgcctgt gaggtgttat ataacattgc tttcatgtat gccaagaagg aggaatggaa 481 aaaagctgaa gaacagttag cattggccac gagcatgaag tctgagccca gacattccaa 541 aatcgacaag gcgatggagt gtgtctggaa gcagaagcta tatgagccag tggtgatccc 601 tgtgggcaag ctgtttcgac caaatgagag acaagtggct cagctggcca agaaggatta 661 cctaggcaag gcgacggtcg tggcatctgt ggtggatcaa gacagtttct ctgggtttgc 721 ccctctgcaa ccacaggcag ctgagcctcc acccagaccg aaaaccccag agatcttcag 781 ggctctggaa ggggaggctc accgtgtgct atttgggttt gtgcctgaga caaaagaaga 841 gctccaggtc atgccaggga acattgtctt tgtcttgaag aagggcaatg ataactgggc 901 cacggtcatg ttcaacgggc agaaggggct tgttccctgc aactaccttg aaccagttga 961 gttgcggatc caccctcagc agcagcccca ggaggaaagc tctccgcagt ccgacatccc 1021 agctcctcct agttccaaag cccctggaaa accccagctg tcaccaggcc agaaacaaaa 1081 agaagagcct aaggaagtga agctcagtgt tcccatgccc tacacactca aggtgcacta 1141 caagtacacg gtagtcatga agactcagcc cgggctcccc tacagccagg tccgggacat 1201 ggtgtctaag aaactggagc tccggctgga acacactaag ctgagctatc ggcctcggga 1261 cagcaatgag ctggtgcccc tttcagaaga cagcatgaag gatgcctggg gccaggtgaa 1321 aaactactgc ctgactctgt ggtgtgagaa cacagtgggt gaccaaggct ttccagatga 1381 acccaaggaa agtgaaaaag ctgatgctaa taaccagaca acagaacctc agcttaagaa 1441 aggcagccaa gtggaggcac tcttcagtta tgaggctacc caaccagagg acctggagtt 1501 tcaggaaggg gatataatcc tggtgttatc aaaggtgaat gaagaatggc tggaagggga 1561 gtgcaaaggg aaggtgggca ttttccccaa agtttttgtt gaagactgcg caactacaga 1621 tttggaaagc actcggagag aagtctagga tgtttcacaa actacaaagc tgaagaaaat 1681 gaagccctat tacttgtttg taagatttaq cacccttctg ctgtatactg tactgagaca WO 00/09525 1295 PCT/US99/17712 1741 ttacagtttg gaagtgttaa ctatttattc cctgttaaaa tttaacctac tagacaatga 1801 tgtgagtacc caggatgatt tcctggggca cagtgggtga ggagatgggg acaggtgaat 1861 ggaggagtta ggggagagga aaagtggatg gaagtgtctg gaaagggcac gagagagtct 1921 tccaggtact gatcctgttt cttgctctga gtgctagcta gccagctgtg ttcacactgt 1981 aaacattcat caagctgtac atttggtgca cttttctgtg tcataccaca ataaaaaaaa 2041 acctatcatc atcttacaaa aacaagacac ccaagtccag gcccaaggag taagtacaaa 2101 tattcctgtt tctgaaccat tactgtaatt ggctcttaag gcttgaagta accttatagg 2161 ttactcataa ggcatataca aataaacttg tttgttttct tttttc (2) INFORMATION FOR SEQ ID NO:137: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 273 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:137: 1 gcagagctgg gcaccacagg gagctaggct ctgtgagccg tggctcatct cacacctcct 61 cactgccttg catcatggcc atgtctggac ccttctctcc tcaggccttt accagaagca 121 ttaaccgaga caagcacttg gcagtggctt acttccaacg agggatgctc tactaccaga 181 cagagaagta agtggttcaa tgttgcacca actggaggat ttcagagaga aacccaaggg 241 gtctcagtgt tgcgggcttg gtgtttgagc agt (2) INFORMATION FOR SEQ ID NO:138: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 420 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:138: 1 ggtcagaagg aactgaaagg cttcttgtcc cagtgagata gctggggaag ggagaagcag 61 actcacattt tatgctgcat ttatttctcc atccactaga ctgctgattt tctccctctg 121 tcctggagat atgatttggc tatcaaagac cttaaagaag ccttgattca gcttcgaggg 181 aaccagctga tagactataa gatcctgggg ctccagttca agctgtttgc ctgtgaggta 241 aggagaacag ggcctggctg ggcaggaggg gatcatggct ggatggatgg ctgacagtca 301 gatgcacagt gatctgttga cacctccagg agcttggaaa agccatttct cctctgcctt 361 gagactcaga ttttccttga agaaaagact gagatggatt atttcaggct catcaaggca (2) INFORMATION FOR SEQ ID NO:139: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 780 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:139: 1 ttccctggca ccttgatttg gagtagtctc aagttttatg tttgcggtct gtacttttct 61 aggtgttata taacattgct ttcatgtatg ccaagaagga ggaatggaaa aaagctgaag 121 aacagttagc attggccacg agcatgaagt ctgagcccag acattccaaa atcgacaagg 181 cgatggagtg tgtctgggta agcgtattgg tgatgcaggt gttgagagga tgtcactgga 241 ttctcatttg tctcagagga catgccattg agaagccata aaagtggtgc ttttactttc 301 tgtgagtctg ggtaacactg atcttagggt atagttccac ttaagatctt gaatctgtgc 361 tgagaagctg aggcctagag tatgggatgg cagagcctgg catcacacca cccttggagt 421 ggggctcctt ggcaatgcag gagaacagga tattggatgc tggagcagtg ctgcacagac 481 tctaagcact gagagggcag agtccatgtc tgcttgatca ccactgagtc ctcacagcct 541 ggcacagtgc taggccacat aacagctctc agcaaaaatg ttttgttttg ttttgagatg 601 gagtctcgct ctgttgccca gcctggagtg cagtggtgtg atctcagctc actgcagcct 661 ctgcctcctg ggttcaagca attctgctgc ctcagccgcc caagtagctg ggattacagg 721 tgcatgccac catgcctggc taatttttgt atttttaata gagacggggt tttgccatgt (2) INFORMATION FOR SEQ ID NO:140: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 278 base pairs -(B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:140: 1 gaattcttgc atctattcac tgagggaggc aggacaagca tcgtcacccc cattttcaca 61 taagggaatg ctacgttttc tgtgttacag aagcagaagc tatatgagcc agtggtgatc 121 cctgtgggca agctgtttcg accaaatgag agacaagtgg ctcagctggc caagaaggat 181 tacctaggca aggcgacggt aggtgggatt gctcagcttc ccctgagtct tcctgtggcc 241 cgggcatgtg gagcaaggtg ggagggactc ttgagaag WO 00/09525 1296 PCTIUS99/17712 (2) INFORMATION FOR SEQ ID NO:141: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 705 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:141: 1 gcaggagaat cacttgaacc tggaaggcag aggttgcagt gagctgagtc actccactgc 61 actccagtct gggtaacaga gcgtgctccg tctcaaaaaa aaaaaaaaaa aaaaagataa 121 tttgatgtta tacaaattgc acctcaatta aaaacatttc ttttttaaga gagaagaaag 181 caagcctgtg ttagcagggg tggggtgaat gctcgtttct tcagttgctg aaatcctaat 241 ccagaggctc aggaatctaa tccttagtta ctgtccacgt ctgaaaccag gctcacgtaa 301 gaacaggtct agggcatgag caaagaggga gacccagaag aatggaaaca gtgctggcag 361 agcctcacac cctcctgtcc ttgattttag gtcgtggcat ctgtggtgga tcaagacagt 421 ttctctgggt ttgcccctct gcaaccacag gtaaggcagt cctgaccttc tccatggacc 481 taggtctcga gagctttctg tgaagcattc aattcgagag actatgtgtg ctgagttgcc 541 tgattgtaag ggctccttca agtggccctc agtgcagctg aggattctgc ctgccctctc 601 tcagtcctgg tttccatagc tggtgaggaa ataaggcagt gtcaggcttc accccaagtc 661 ctctgaagct aactctcctg cttccccaca aatgccggtc ttcac (2) INFORMATION FOR SEQ ID NO:142: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 709 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:142: 1 actgaattgc tgtgctagtg aaacctgtac ctgggagctg gtgggaggtg ttatttccca 61 gtgtttagtc agggtgactg tgccctcttc ctagacagtg ttctcatcag tcagaaatgc 121 gttatttgat tttctggtct ggaagaatgc tcaaattacc attagccgtt tgttgtctct 181 cccctgcttt ccctcattgc cttttccgtt ttcacttctc ctgaatgttc aataggcagc 241 tgagcctcca cccagaccga aaaccccaga gatcttcagg taagttagat tcaaatccat 301 aaatagaata tcaagcgcca agcctgagct gatggcaaga aagggaggga agaagatgaa 361 ggtggggtca gggtctaaat cttgttgaat tttctggaat gtcaggcttc ttctagaatg 421 tcaggctaga aaggaatgcc tagaagaatg tcttctagaa tgtcaggcta gaaaggaatg 481 atatatgggg atgggagtct tgactgtggt ggggctggcc atcagggctt ggctgcagct 541 acgtggtcca ttggccctct gtccacgtgc acagccacca catgcagggg ttgtgctgag 601 ggcagtgtgt cctgtggaac atagctacct gggaccagat gctgacctca ggttggagat 661 cggtttcgca ctggctgcag tcctctgacg gggcaggcca gagctctct (2) INFORMATION FOR SEQ ID NO:143: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 849 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:143: 1 tgagcagtgt acaccagttt cttgctgaga cctcttggac ccaggcaggc tcagtgtcat 61 ctcggcagtt gcagttagat gtggagttag agccaggctg agccaagtcc ctggctccaa 121 gttcagtgta tttgcgccat ggcatcatgt gaggggatgg gggctggatc ttgtgtctat 181 cctctgcagg gctctggaag gggaggctca ccgtgtgcta tttgggtttg tgcctgagac 241 aaaagaagag ctccaggtca tgccagggaa cattgtcttt gtcttgaaga agggcaatga 301 taactgggcc acggtcatgt tcaacgggca ggtatgcaga ggatcagggg ctggtgcgat 361 gggcatggga tcctggcagc aaatgcagtc tctgtggagc agtatctgct gccttctttg 421 cagaccagcc aagttctttt gtctgttcgt catcccttcc ccaggactct gggctgttct 481 gtggtgtggg tactgatgag cacatcttta ttttttcctt tctgattctg tggtgctgca 541 ctgcagaagg ggcttgttcc ctgcaactac cttgaaccag ttgagctgcg gatccaccct 601 cagcagcagc cccaggtaat gtgatgccaa ggcctgaccc atttcctctc accctttagg 661 atctctccct ggagggagaa aagcagtgta aaagaggtgt tgtcaggacc cctggagaaa 721 gattcactag tcttgagccc gccttgagat ggcaccagct acccagagct gaacctggga 781 atgaggggaa aaaagcccag atgtgctaag ttggaggcat ctgtaggtcc cattggccca 841 cccacctct (2) INFORMATION FOR SEQ ID NO:144: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 308 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:144: 1 aatgtcacta ccattccaac ttttaggacg ttatctgcat gtggctcctt tacatggggt 61 ctctgtaggg gtgtttcccc acatccaccc ctgcctggga actttgaatg aaggttctga 121 ccatcgctcc ctgttgcctt caggaggaaa gctctccgca gtccgacatc ccagctcctc WO 00/09525 1297 PCT/US99/17712 181 ctagttccaa agcccctgga agaccccagc tgtcaccagg tgagtggtcc tggagccaca 241 gcctaggttt gggtgcagca gcatgccagg tgttcctgag ttcctctccc tgccttccag 301 gaaattct (2) INFORMATION FOR SEQ ID NO:145: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 463 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:145: 1 gactgagttt gttcatgtgt tcatgacctt catgcttccc cagggcgaga tttccccaca 61 gtttactaag gttaataatt gccccacaaa ttaaagggta agaggttggg ggccctattt 121 gaagaggttt catctgtgtg tggcaggggc tggccaagga tgttcattca ccatcttctt 181 ttgttttact ccctactttt tccattcagg ccagaaacaa aaagaagagc ctaaggtaac 241 atttttccct catactgttt caagtggtag aagatgggat agcttgggct atcaaccaca 301 gacatgtctg tctggattat aggaagagcc caaaggaggg tcgaaccagt tgctacctta 361 cagagtccat gagctaggga ccttcttaat agcctcctcc actatcatgc acacacttcc 421 tactacccaa gctagtgggc cagatcttac tcagtaggaa ttc (2) INFORMATION FOR SEQ ID NO:146: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 784 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:146: 1 gaattcctgt ccaagcaagg gttgggctaa aggacctctg aaggcctttt aggctactgt 61 gaaaccagtt acttactggc ctctcccctg ctgtattggg taccccctgt gccaaatcac 121 gaaactgcgg tgatccagga tgttgagaga aagcctcaga cactcaggag ttccctttgt 181 ttcctcccca ctcaggaagt gaagctcagt gttcccatgc cctacacact caaggtgcac 241 tacaagtaca cggtagtcat gaagactcag cccgggctcc cctacagcca ggtccgggac 301 atggtgtcta agaaactgga gctccggctg gaacacacta agctgaggtg agctccatgc 361 aggcagctgt gaggggtaca gtgggaacct tgtgctggcc tggaggaggg aagaggagga 421 tggtttttgt gatgatgttc tttgactgga ttcttactca ttatccccac ccagctatcg 481 gcctcgggac agcaatgagc tggtgcccct ttcagaagac agcatgaagg atgcctgggg 541 ccaggtgaaa aactactgcc tgactctgtg gtgtgagaac acagtggtga gtgcaatgag 601 gggcatctaa agttacattt ccactgagcc acttcctcaa caatttgaaa tttatcaagc 661 accttctgtg tactaggcac tatatgtggt gttggggata tggtgtgtaa taagtcacag 721 ctctgcctcc cttttacctg catcctcacc ccatttgcag cagggagaga gtttcccaca 781 agag (2) INFORMATION FOR SEQ ID NO:147: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 450 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:147: 1 ttcataaaga gcatataagc tctacacaag gcactgatca caaactttat gagtttatat 61 cccaggttct actttgacat ttcgctgttt cctttagtga tgttcagtgt tcacttggca 121 ggaaattggg aaaattaaca ggccctttat tatttcaggg tgaccaaggc tttccagatg 181 aacccaagga aagtgaaaaa gctgatgcta ataaccagac aacagaacct cagcttaaga 241 aaggcagcca agtggaggca ctcttcagtt atgaggctac ccaaccagag gacctggagt 301 ttcaggaagg ggatataatc ctggtgttat caaagggtaa gtgctactcc aagactatag 361 aaacaaattt acatgttagc agaaacaagg tcaagggcag agagaagaaa tatcaataat 421 ctacaaacaa aactttagcc agtgttttca (2) INFORMATION FOR SEQ ID NO:148: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1145 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:148: 1 gtcaattctt gaccctcttc tctatctggt aactttttga aaaacataat ttatcctctc 61 ttcattttgc tcattatcat gtttaagaca gatcaataag atggttaaac cctgtgttca 121 ctctcaaacc actttgcaat actgtctttt ccctgttgat cacaattagg ggtggggaag 181 ggtgaccgat aacaaattct gtgtggaata gccagacagg gtaatcttcc tacagtggtt 241 ttagaaatcc atgtgtactt ttccttttat cagtgaatga agaatggctg gaaggggagt 301 gcaaagggaa ggtgggcatt ttccccaaag tttttgttga agactgcgca actacagatt WO 00/09525 1298 PCT/US99/17712 361 tggaaagcac tcggagagaa gtctaggatg tttcacaaac tacaaagctg aagaaaatga 421 agccctatta cttgtttgta agatttagca cccttctgct gtatactgta ctgagacatt 481 acagtttgga agtgttaact atttattccc tgttaaaatt taacctacta gacaatgatg 541 tgagtaccca ggatgatttc ctggggcaca gtgggtgagg agatggggac aggtgaatgg 601 aggagttagg ggagaggaaa agtggatgga agtgtctgga aagggcacga gagagtcttc 661 caggtactga tcctgtttct tgctctgagt gctagctagc cagctgtgtt cacactgtaa 721 acattcatca agctgtacat ttggtgcact tttctgtgtc ataccacaat aaaaaaaaac 781 ctatcatctt acaaaaacaa gacacccaag tccaggccca aggagtaagt acaaatattc 841 ctgtttctga accattactg taattggctc ttaaggcttg aagtaacctt ataggttact 901 cataaggcat atacaaataa acttgtttgt tttctttttt cattatgtct tgttgcttaa 961 acagaaccta gactgagtta ggttctcatg gactacaaca ctcaattcca cagagaatta 1021 atagaattac atacctttgt acattctcag agaggaacat gtgttaagaa ctcaatactg 1081 aatatatatc aatcgccaac atttaagtga tgaaaagcag cggtgttcat gaagctagtt 1141 cgtaa (2) INFORMATION FOR SEQ ID NO:149: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 75 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:149: 1 gtcacatcgc cctgctgggc tttgagaagc gcttcgtacc cagccagcac tatgtgtaca 61 tgttcctggt gaaat (2) INFORMATION FOR SEQ ID NO:150: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 10335 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:150: 1 ctagtctttc agccttcagg ctgtttttgg cttgaagctc tcttggcctc ctagtttcta 61 cctaatcatg tccctggtgg aggccatcag cctctggaat gaaggggtgc tggcagcgga 121 caagaaggac tggaagggag ccctggatgc cttcagtgcc gtccaggacc cccactcccg 181 gatttgcttc aacattggct gcatgtacac tatcctgaag aacatgactg aagcagagaa 241 ggcctttacc agaagcatta accgagacaa gcacttggca gtggcttact tccaacgagg 301 gatgctctac taccagacag agaaatatga tttggctatc aaagacctta aagaagcctt 361 gattcagctt cgagggaacc agctgataga ctataagatc ctggggctcc agttcaagct 421 gtttgcctgt gaggtgttat ataacattgc tttcatgtat gccaagaagg aggaatggaa 481 aaaagctgaa gaacagttag cattggccac gagcatgaag tctgagccca gacattccaa 541 aatcgacaag gcgatggagt gtgtctggaa gcagaagcta tatgagccag tggtgatccc 601 tgtgggcaag ctgtttcgac caaatgagag acaagtggct cagctggcca agaaggatta 661 cctaggcaag gcgacggtcg tggcatctgt ggtggatcaa gacagtttct ctgggtttgc 721 ccctctgcaa ccacaggcag ctgagcctcc acccagaccg aaaaccccag agatcttcag 781 ggctctggaa ggggaggctc accgtgtgct atttgggttt gtgcctgaga caaaagaaga 841 gctccaggtc atgccaggga acattgtctt tgtcttgaag aagggcaatg ataactgggc 901 cacggtcatg ttcaacgggc agaaggggct tgttccctgc aactaccttg aaccagttga 961 gttgcggatc caccctcagc agcagcccca ggaggaaagc tctccgcagt ccgacatccc 1021 agctcctcct agttccaaag cccctggaaa accccagctg tcaccaggcc agaaacaaaa 1081 agaagagcct aaggaagtga agctcagtgt tcccatgccc tacacactca aggtgcacta 1141 caagtacacg gtagtcatga agactcagcc cgggctcccc tacagccagg tccgggacat 1201 ggtgtctaag aaactggagc tccggctgga acacactaag ctgagctatc ggcctcggga 1261 cagcaatgag ctggtgcccc tttcagaaga cagcatgaag gatgcctggg gccaggtgaa 1321 aaactactgc ctgactctgt ggtgtgagaa cacagtgggt gaccaaggct ttccagatga 1381 acccaaggaa agtgaaaaag ctgatgctaa taaccagaca acagaacctc agcttaagaa 1441 aggcagccaa gtggaggcac tcttcagtta tgaggctacc caaccagagg acctggagtt 1501 tcaggaaggg gatataatcc tggtgttatc aaaggtgaat gaagaatggc tggaagggga 1561 gtgcaaaggg aaggtgggca ttttccccaa agtttttgtt gaagactgcg caactacaga 1621 tttggaaagc actcggagag aagtctagga tgtttcacaa actacaaagc tgaagaaaat 1681 gaagccctat tacttgtttg taagatttag cacccttctg ctgtatactg tactgagaca 1741 ttacagtttg gaagtgttaa ctatttattc cctgttaaaa tttaacctac tagacaatga 1801 tgtgagtacc caggatgatt tcctggggca cagtgggtga ggagatgggg acaggtgaat 1861 ggaggagtta ggggagagga aaagtggatg gaagtgtctg gaaagggcac gagagagtct 1921 tccaggtact gatcctgttt cttgctctga gtgctagcta gccagctgtg ttcacactgt 1981 aaacattcat caagctgtac atttggtgca cttttctgtg tcataccaca ataaaaaaaa 2041 acctatcatc atcttacaaa aacaagacac ccaagtccag gcccaaggag taagtacaaa 2101 tattcctgtt tctgaaccat tactgtaatt ggctcttaag gcttgaagta accttatagg 2161 ttactcataa ggcatataca aataaacttg tttgttttct tttttc 1 ctagtctttc agccttcagg ctgtttttgg cttgaagctc tcttggcctc ctagtttcta 61 cctaatcatg tccctggtgg aggccatcag cctctggaat gaaggggtgc tggcagcgga 121 caagaaggac tggaagggag ccctggatgc cttcagtgcc gtccaggacc cccactcccg 181 gatttgcctc aacattggct gcatgctacac tatcctgaag aacatgactg aagcagagaa WO 00/09525 1299 PCT/US99/17712 241 ggcctttacc agaagcatta accgagacaa gcactcggca gtggcttact tccaacqagg 301 gatgctctac taccagacag agaaatatga tttggctatc aaagacctta aagaagcctt 361 gattcagctt cgagggaacc agctgataga ctataagatc ctggggctcc agttcaagct 421 gtttgcctgt gaggtgttat ataacattgc tttcatgtat gccaagaagg aggaatggaa 481 aaaagctgaa gaacagttag cattggccac gagcatgaag tctgagccca gacattccaa 541 aatcgacaag gcgatggagt gtgtctggaa gcagaagcta tatgagccag tggtgatccc 601 tgtgggcaag ctgtttcgac caaatgagag acaagtggct cagctggcca agaaggatta 661 cctaggcaag gcgacggtcg tggcatctgt ggtggatcaa gacagtttct ctgggtttgc 721 ccctctgcaa ccacagqcag ctgagcctcc acccagaccg aaaaccccag agatcttcag 781 ggctctggaa ggggaggctc accgtgtgct atttgggttt gtgcctgaga caaaagaaga 841 gctccaggtc atgccaggga acattgtctt tgtcttgaag aagggcaatg ataactgggc 901 cacggtcatg ttcaacgggc agaaggggct tgttccctgc aactaccttg aaccagttga 961 gttgcggatc caccctcagc agcagcccca ggaggaaagc tctccgcagt ccgacatccc 1021 agctcctcct agttccaaag cccctggaaa accccagctg tcaccaggcc agaaacaaaa 1081 agaagagcct aaggaagtga agctcagtgt tcccatgccc tacacactca aggtgcacta 1141 caagtacacg gtagtcatga agactcagcc cgggctcccc tacagccagg tccgggacat 1201 ggtgtctaag aaactggagc tccggctgga acacactaag ctgagctatc ggcctcggga 1261 cagcaatgag ctggtgcccc tttcagaaga cagcatgaag gatgcctggg gccaggtgaa 1321 aaactactgc ctgactctgt ggtgtgagaa cacagtgggt gaccaaggct ttccagatga 1381 acccaaggaa agtgaaaaag ctgatgctaa taaccagaca acagaacctc agcttaagaa 1441 aggcagccaa gtggaggcac tcttcagtta tgaggctacc caaccagagg acctggagtt 1501 tcaggaaggg gatataatcc tggtgttatc aaaggtgaat gaagaatggc tggaagggga 1561 gtgcaaaggg aaggtgggca ttttccccaa agtttttgtt gaagactgcg caactacaga 1621 tttggaaagc actcggagag aagtctagga tgtttcacaa actacaaagc tgaagaaaat 1681 gaagccctat tacttgtttg taagatttag cacccttctg ctgtatactg tactgagaca 1741 ttacagtttg gaagtgttaa ctatttattc cctgttaaaa tttaacctac tagacaatga 1801 tgtgagtacc caggatgatt tcctggggca cagtgggtga ggagatgggg acaggtgaat 1861 ggaggagtta ggggagagga aaagtggatg gaagtgtctg gaaagggcac gagagagtct 1921 tccaggtact gatcctgttt cttgctctga gtgctagcta gccagctgtg ttcacactgt 1981 aaacattcat caagctgtac atttggtgca cttttctgtg tcataccaca ataaaaaaaa 2041 acctatcatc atcttacaaa aacaagacac ccaagtccag gcccaaggag taagtacaaa 2101 tattcctgtt tctgaaccat tactgtaatt ggctcttaag gcttgaagta accttatagg 2161 ttactcataa ggcatataca aataaacttg tttgttttct tttttc 1 gcagagctgg gcaccacagg gagctaggct ctgtgagccg tggctcatct cacacctcct 61 cactgccttg catcatggcc atgtctggac ccttctctcc tcaggccttt accagaagca 121 ttaaccgaga caagcacttg gcagtggctt acttccaacg agggatgctc tactaccaga 181 cagagaagta agtggttcaa tgttgcacca actggaggat ttcagagaga aacccaaggg 241 gtctcagtgt tgcgggcttg gtgtttgagc agt 1 ggtcagaagg aactgaaagg cttcttgtcc cagtgagata gctggggaag ggagaagcag 61 actcacattt tatgctgcat ttatttctcc atccactaga ctgctgattt tctccctctg 121 tcctggagat atgatttggc tatcaaagac cttaaagaag ccttgattca gcttcgaggg 181 aaccagctga tagactataa gatcctgggg ctccagttca agctgtttgc ctgtgaggta 241 aggagaacag ggcctggctg ggcaggaggg gatcatggct ggatggatgg ctgacagtca 301 gatgcacagt gatctgttga cacctccagg agcttggaaa agccatttct cctctgcctt 361 gagactcaga ttttccttga agaaaagact gagatggatt atttcaggct catcaaggca 1 ttccctggca ccttgatttg gagtagtctc aagttttatg tttgcggtct gtacttttct 61 aggtgttata taacattgct ttcatgtatg ccaagaagga ggaatggaaa aaagctgaag 121 aacagttagc attggccacg agcatgaagt ctgagcccag acattccaaa atcgacaagg 181 cgatggagtg tgtctgggta agcgtattgg tgatgcaggt gttgagagga tgtcactgga 241 ttctcatttg tctcagagga catgccattg agaagccata aaagtggtgc ttttactttc 301 tgtgagtctg ggtaacactg atcttagggt atagttccac ttaagatctt gaatctgtgc 361 tgagaagctg aggcctagag tatgggatgg cagagcctgg catcacacca cccttggagt 421 ggggctcctt ggcaatgcag gagaacagga tattggatgc tggagcagtg ctgcacagac 481 tctaagcact gagagggcag agtccatgtc tgcttgatca ccactgagtc ctcacagcct 541 ggcacagtgc taggccacat aacagctctc agcaaaaatg ttttgttttg ttttgagatg 601 gagtctcgct ctgttgccca gcctggagtg cagtggtgtg atctcagctc actgcagcct 661 ctgcctcctg ggttcaagca attctgctgc ctcagccgcc caagtagctg ggattacagg 721 tgcatgccac catgcctggc taatttttgt atttttaata gagacggggt tttgccatgt 1 gaattcttgc atctattcac tgagggaggc aggacaagca tcgtcacccc cattttcaca 61 taagggaatg ctacgttttc tgtgttacag aagcagaagc tatatgagcc agtggtgatc 121 cctgtgggca agctgtttcg accaaatgag agacaagtgg ctcagctggc caagaaggat 181 tacctaggca aggcgacggt aggtgggatt gctcagcttc ccctgagtct tcctgtggcc 241 cgggcatgtg gagcaaggtg ggagggactc ttgagaag 1 gcaggagaat cacttgaacc tggaaggcag aggttgcagt gagctgagtc actccactgc 61 actccagtct gggtaacaga gcgtgctccg tctcaaaaaa aaaaaaaaaa aaaaagataa 121 tttgatgtta tacaaattgc acctcaatta aaaacatttc ttttttaaga gagaagaaag 181 caagcctgtg ttagcagggg tggggtgaat gctcgtttct tcagttgctg aaatcctaat 241 ccagaggctc aggaatctaa tccttagtta ctgtccacgt ctgaaaccag gctcacgtaa 301 gaacaggtct agggcatgag caaagaggga gacccagaag aatggaaaca gtgctggcag 361 agcctcacac cctcctgtcc ttgattttag gtcgtggcat ctgtggtgga tcaagacagt 421 ttctctgggt ttgcccctct gcaaccacag gtaaggcagt cctgaccttc tccatggacc 481 taggtctcga gagctttctg tgaagcattc aattcgagag actatgtgtg ctgagttgcc 541 tgattgtaag ggctccttca agtggccctc agtgcagctg aggattctgc ctgccctctc 601 tcagtcctgg tttccatggc tggtgaggaa ataaggcagt gtcaggcttc accccaagtc 661 ctctgaagct aactctcctg cttccccaca aatgccggtc ttcac WO 00/09525 1300 PCT/US99/17712 1 actgaattgc tgtgctagtg aaacctgtac ctgggagctg gtgggaggtg ttatttccca 61 gtgtttagtc agggtgactg tgccctcttc ctagacagtg ttctcatcag tcagaaatgc 121 gttatttgat tttctggtct ggaagaatgc tcaaattacc attagccgtt tgttgtctct 181 cccctgcttt ccctcattgc cttttccgtt ttcacttctc ctgaatgttc aataggcagc 241 tgagcctcca cccagaccga aaaccccaga gatcttcagg taagttagat tcaaatccat 301 aaatagaata tcaagcgcca agcctgagct gatggcaaga aagggaggga agaagatgaa 361 ggtggggtca gggtctaaat cttgttgaat tttctggaat gtcaggcttc ttctagaatg 421 tcaggctaga aaggaatgcc tagaagaatg tcttctagaa tgtcaggcta gaaaggaatg 481 atatatgggg atgggagtct tgactgtggt ggggctggcc atcagggctt ggctgcagct 541 acgtggtcca ttggccctct gtccacgtgc acagccacca catgcagggg ttgtgctgag 601 ggcagtgtgt cctgtggaac atagctacct gggaccagat gctgacctca ggttggagat 661 cggtttcgca ctggctgcag tcctctgacg gggcaggcca gagctctct 1 tgagcagtgt acaccagttt cttgctgaga cctcttggac ccaggcaggc tcagtgtcat 61 ctcggcagtt gcagttagat gtggagttag agccaggctg agccaagtcc ctggctccaa 121 gttcagtgta tttgcgccat ggcatcatgt gaggggatgg gggctggatc ttgtgtctat 181 cctctgcagg gctctggaag gggaggctca ccgtgtgcta tttgggtttg tgcctgagac 241 aaaagaagag ctccaggtca tgccagggaa cattgtcttt gtcttgaaga agggcaatga 301 taactgggcc acggtcatgt tcaacgggca agtatgcaga ggatcagggg ctggtgcgat 361 gggcatggga tcctggcagc aaatgcagtc tctgtggagc agtatctgct gccttctttg 421 cagaccagcc aagttctttt gtctgttcgt catccctcc ccaggactct gggctgttct 481 gtggtgtggg tactgatgag cacatcttta ttttttcctt tctgattctg tggtgctgca 541 ctgcagaagg ggcttgttcc ctgcaactac cttgaaccag ttgagctgcg gatccaccct 601 cagcagcagc cccaggtaat gtgatgccaa ggcctgaccc atttcctctc accctttagg 661 atctctccct ggagggagaa aagcagtgta aaagaggtgt tgtcaggacc cctggagaaa 721 gattcactag tcttgagccc gccttgagat ggcaccagct acccagagct gaacctggga 781 atgaggggaa aaaagcccag atgtgctaag ttggaggcat ctgtaggtcc cattggccca 841 cccacctct 1 aatgtcacta ccattccaac ttttaggacg ttatctgcat gtggctcctt tacatggggt 61 ctctgtaggg gtgtttcccc acatccaccc ctgcctggga actttgaatg aaggttctga 121 ccatcgctcc ctgttgcctt caggaggaaa gctctccgca gtccgacatc ccagctcctc 181 ctagttccaa agcccctgga agaccccagc tgtcaccagg tgagtggtcc tggagccaca 241 gcctaggttt gggtgcagca gcatgccagg tgttcctgag ttcctctccc tgccttccag 301 gaaattct 1 gactgagttt gttcatgtgt tcatgacctt catgcttccc cagggcgaga tttccccaca 61 gtttactaag gttaataatt gccccacaaa ttaaagggta agaggttggg ggccctattt 121 gaagaggttt catctgtgtg tggcaggggc tggccaagga tgttcattca ccatcttctt 181 ttgttttact ccctactttt tccattcagg ccagaaacaa aaagaagagc ctaaggtaac 241 atttttccct catactgttt caagtggtag aagatgggat agcttgggct atcaaccaca 301 gacatgtctg tctggattat aggaagagcc caaaggaggg tcgaaccagt tgctacctta 361 cagagtccat gagctaggga ccttcttaat agcctcctcc actatcatgc acacacttcc 421 tactacccaa gctagtgggc cagatcttac tcagtaggaa ttc 1 gaattcctgt ccaagcaagg gttgggctaa aggacctctg aaggcctttt aggctactgt 61 gaaaccagtt acttactggc ctctcccctg ctgtattggg taccccctgt gccaaatcac 121 gaaactgcgg tgatccagga tgttgagaga aagcctcaga cactcaggag ttccctttgt 181 ttcctcccca ctcaggaagt gaagctcagt gttcccatgc cctacacact caaggtgcac 241 tacaagtaca cggtagtcat gaagactcag cccgggctcc cctacagcca ggtccgggac 301 atggtgtcta agaaactgga gctccggctg gaacacacta agctgaggtg agctccatgc 361 aggcagctgt gaggggtaca gtgggaacct tgtgctggcc tggaggaggg aagaggagga 421 tggtttttgt gatgatgttc tttgactgga ttcttactca ttatccccac ccagctatcg 481 gcctcgggac agcaatgagc tggtgcccct ttcagaagac agcatgaagg atgcctgggg 541 ccaggtgaaa aactactgcc tgactctgtg gtgtgagaac acagtggtga gtgcaatgag 601 gggcatctaa agttacattt ccactgagcc acttcctcaa caatttgaaa tttatcaagc 661 accttctgtg tactaggoac tatatgtggt gttggggata tggtgtgtaa taagtcacag 721 ctctgcctcc cttttacctg catcctcacc ccatttgcag cagggagaga gtttcccaca 781 agag 1 ttcataaaga gcatataagc tctacacaag gcactgatca caaactttat gagtttatat 61 cccaggttct actttgacat ttcgctgttt cctttagtga tgttcagtgt tcacttggca 121 ggaaattggg aaaattaaca ggccctttat tatttcaggg tgaccaaggc tttccagatg 181 aacccaagga aagtgaaaaa gctgatgcta ataaccagac aacagaacct cagcttaaga 241 aaggcagcca agtggaggca ctcttcagtt atgaggctac ccaaccagag gacctggagt 301 ttcaggaagg ggatataatc ctggtgttat caaagggtaa gtgctactcc aagactatag 361 aaacaaattt acatgttagc agaaacaagg tcaagggcag agagaagaaa tatcaataat 421 ctacaaacaa aactttagcc agtgttttca 1 gtcaattctt gaccctcttc tctatctggt aactttttga aaaacataat ttatcctctc 61 ttcattttgc tcattacat gtttaagaca gatcaataag atggttaaac cctgtgttca 121 ctccaaacc acttgcaat actgtctttt ccctgttgat cacaattagg ggtggggaag 181 ggtgaccgat aacaaattct gtgtggaata gccagacagg gtaatcttcc tacagtggtt 241 ttagaaatcc atgtgtactct ttccttttat cagtgaatga agaatggctg gaaggggagt 301 gcaaagggaa ggtgggcatt ttccccaaag tttttgttga agactgcgca actacagatt 361 tggaaagcac tcggagagaa gtctaggatg tttcacaaac tacaaagctg aagaaaatga 421 agccctatta ctgtttgta agatttagca cccttctgct gtatactgta ctgagacatt 481 acagtttgga agtgttaact attattccc tgttaaaatt taacctacta gacaatgatg 541 tgagtaccca ggatgatttc ctggggcaca gtgggtgagg agatggggac aggtgaatgg 601 aggagttagg ggagaggaaa agtggactgga agtgtctgga aagggcacga gagagtcttc 661 caggtactga tcctgtttct tgctctgagt gCtagctagc cagctgtgtt cacactgtaa WO 00/09525 1301 PCT/US99/17712 721 acattcatca agctgtacat ttggtgcact tttctgtgtc ataccacaat aaaaaaaaac 781 ctatcatctt acaaaaacaa gacacccaag tccaggccca aggagtaagt acaaatattc 841 ctgtttctga accattactg taattggctc ttaaggcttg aagtaacctt ataggttact 901 cataaggcat atacaaataa acttgtttgt tttctttttt cattatgtct tgttgcttaa 961 acagaaccta gactgagtta ggttctcatg gactacaaca ctcaattcca cagagaatta 1021 atagaattac atacctttgt acattctcag agaggaacat gtgttaagaa ctcaatactg 1081 aatatatatc aatcgccaac atttaagtga tgaaaagcag cggtgttcat gaagctagtt 1141 cgtaa 1 gtcacatcgc cctgctgggc tttgagaagc gcttcgtacc cagccagcac tatgtgtaca 61 tgttcctggt gaaat (2) INFORMATION FOR SEQ ID NO:151: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1064 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:151: 1 ccagctgata ttccagccca cagcaatgga gccacatgac tcctcccaca tggactctga 61 gttccgatac actctcttcc cgattgttta cagcatcatc tttgtgctcg gggtcattgc 121 taatggctac gtgctgtggg tctttgcccg cctgtaccct tgcaagaaat tcaatgagat 181 aaagatcttc atggtgaacc tcaccatggc ggacatgctc ttcttgatca ccctgccact 241 ttggattgtc tactaccaaa accagggcaa ctggatactc cccaaattcc tgtgcaacgt 301 ggctggctgc cttttcttca tcaacaccta ctgctctgtg gccttcctgg gcgtcatcac 361 ttataaccgc ttccaggcag taactcggcc catcaagact gctcaggcca acacccgcaa 421 gcgtggcatc tctttgtcct tggtcatctg ggtggccatt gtgggagctg catcctactt 481 cctcatcctg gactctacca acacagtgcc cgacagtgct ggctcaggca acgtcactcg 541 ctgctttgag cattacgaga agggcagcgt gccagtcctc atcatccaca tcttcatcgt 601 gttcagcttc ttcctggtct tcctcatcat cctcttctgc aacctggtca tcatccgtac 661 cttgctcatg cagccggtgc agcagcagcg caacgctgaa gtcaagcgcc gggcgctgtg 721 gatggtgtgc acggtcttgg cggtgttcat catctgcttc gtgccccacc acgtggtgca 781 gctgccctgg acccttgctg agctgggctt ccaggacagc aaattccacc aggccattaa 841 tgatgcacat caggtcaccc tctgcctcct tagcaccaac tgtgtcttag accctgttat 901 ctactgtttc ctcaccaaga agttccgcaa gcacctcacc gaaaagttct acagcatgcg 961 cagtagccgg aaatgctccc gggccaccac ggatacggtc actgaagtgg ttgtgccatt 1021 caaccagatc cctggcaatt ccctcaaaaa ttagtccttg cttc (2) INFORMATION FOR SEQ ID NO:152: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1780 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:152: 1 ttcacgaggg ctggggccag gacccagaca gagacacacg gtcactgcag ctgaagccgc 61 tgcccctgct acaggcacca ccaggaccag ctgatcattc cagcccacag caatggagcc 121 acatgactcc tcccacatgg actctgagtt ccgatacact ctcttcccga ttgtttacag 181 catcatcttt gtgctcgggg tcattgctaa tggctacgtg ctgtgggtct ttgcccgcct 241 gtacccttgc aagaaattca atgagataaa gatcttcatg gtgaacctca ccatggcgga 301 catgctcttc ttgatcaccc tgccactttg gattgtctac taccaaaacc agggcaactg 361 gatactcccc aaattcctgt gcaacgtggc tggctgcctt ttcttcatca acacctactg 421 ctctgtggcc ttcctgggcg tcatcactta taaccgcttc caggcagtaa ctcggcccat 481 caagactgct caggccaaca cccgcaagcg tggcatctct ttgtccttgg tcatctgggt 541 ggccattgtg ggagctgcat cctacttcct catcctggac tccaccaaca cagtgcccga 601 cagtgctggc tcaggcaacg tcactcgctg ctttgagcat tacgagaagg gcagcgtgcc 661 agtcctcatc atccacatct tcatcgtgtt cagcttcttc ctggtcttcc tcatcatcct 721 cttctgcaac ctggtcatca tccgtacctt gctcatgcag ccggtgcagc agcagcgcaa 781 cgctgaagtc aagcgccggg cgctgtggat ggtgtgcacg gtcttggcgg tgttcatcat 841 ctgcttcgtg ccccaccacg tggtgcagct gccctggacc cttgctgagc tgggcttcca 901 ggacagcaaa ttccaccagg ccattaatga tgcacatcag gtcaccctct gcctccttag 961 caccaactgt gtcttagacc ctgttatcta cigtttcctc accaagaagt tccgcaagca 1021 cctcaccgaa aagttctaca gcatgcgcag tagccggaaa tgctcccggg ccaccacgga 1081 tacggtcact gaagtggttg tgccattcaa ccagatccct ggcaattccc tcaaaaatta 1141 gtccctgctt ccaggcctga agtctctcc tccatgaaac atcatgactg agctggggga 1201 agaagggata tctactgtgg gtctgggcac cacctctgtg gcactggtgg gccattagat 1261 ttggaggcta cctcacctgg gcagggatga tgcagagcca ggctgttgga aaatccagaa 1321 ctcaaatgag ccccttcatc cgcctgtggg cgcatactac agtaactgtg actgatgact 1381 ttatcctgag tcccttaatc ttatggggcc ggaaggaatg tcagggccag gtgcagacct 1441 tgggggaaga ctttaaacca cctagttctc ccactggggc atcggtctaa agctttgggg 1501 gagtggcccc agtggctcac acctgtaatc ccagcacttt gggaggccga Qgtgggcaga 1561 tcatgggtca agagatcgag acatcctggc caacattgta aaaccccarc tctactaaaa 1621 catacaaaaa ttagccgggc atggtgcaca cgcctgtagt cccagctact caggaggctg 1681 aggcaggaga atcgcttgaa cctgggaggc agaggttgca ggaacctag attgcaccat WO 00/09525 1302 PCT/US99/17712 1741 tgcactctag cctggcaaca gaggcagatt ccctcctgcc (2) INFORMATION FOR SEQ ID NO:153: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1467 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:153: 1 cgggaggcgg aggttgcggt gagctgagat cacgccactg cactccagcc tgggcagcaa 61 gagtgaaact ccatctgaaa aaaaaaaaaa gattcaacat gaacttctga ggggacatca 121 tcattctaac catggcaagg agtcttggaa ctgatgaaat ggaacagtcc cttcttgtcc 181 ctttattaac cagaattttt gtgtggtctt ccaggcacca ccaggaccag ctgatcattc 241 cagcccacag caatggagcc acatgactcc tcccacatgg actctgagtt ccgatacact 301 ctcttcccga ttgtttacag catcatcttt gtgctcgggg tcattgctaa tggctacgtg 361 ctgtgggtct ttgcccgcct gtacccttgc aagaaattca atgagataaa gatcttcatg 421 gtgaacctca ccatggcgga catgctcttc ttgatcaccc tgccactttg gattgtctac 481 taccaaaacc agggcaactg gatactcccc aaattcctgt gcaacgtggc tggctgcctt 541 ttcttcatca acacctactg ctctgtggcc ttcctgggcg tcatcactta taaccgcttc 601 caggcagtaa ctcggcccat caagactgct caggccaaca cccgcaagcg tggcatctct 661 ttgtccttgg tcatctgggt ggccattgtg ggagctgcat cctacttcct catcctggac 721 tccaccaaca cagtgcccga cagtgctggc tcaggcaacg tcactcgctg ctttgagcat 781 tacgagaagg gcagcgtgcc agtcctcatc atccacatct tcatcgtgtt cagcttcttc 841 ctggtcttcc tcatcatcct cttctgcaac ctggtcatca tccgtacctt gctcatgcag 901 ccggtgcagc agcagcgcaa cgctgaagtc acaggccggg cgctgtggat ggtgtgcacg 961 gtcttggcgg tgttcatcat ctgcttcgtg ccccaccacg tggtgcagct gccctggacc 1021 cttgctgagc tgggcttcca ggacagcaaa ttccaccagg ccattaatga tgcacatcag 1081 gtcaccctct gcctccttag caccaactat gtcttagacc ctgttatcta ctgtttcctc 1141 accaagaagt tccgcaagca cctcaccgaa aagttctaca gcatgcgcag tagccggaaa 1201 tgctcccggg ccaccacgga tacggtcact gaagtggttg tgccattcaa ccagatccct 1261 ggcaattccc tcaaaaatta gtccctgctt ccaggcctga agtcttctcc tccatgaaca 1321 tcatggactg agctggggga agaagggata tctactgtgg tctgggcacc acctctgtgg 1381 gcactggtgg gccattagat ttggaggcta cctcacctgg gcagggatga tggcagacga 1441 ggctgttgga aaatccagaa ctcaaat (2) INFORMATION FOR SEQ ID NO:154: )i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 4311 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single )D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:154: 1 ccagctgaca ttccagccca cagcaatgga gccacatgac tcctcccaca tggactctga 61 gttccgatac actctcttcc cgattgttta cagcatcatc tttgtgctcg gggtcattgc 121 taatggctac gtgctgtggg tctttgcccg cctgtaccct tgcaagaaat tcaatgagat 181 aaagatcttc atggtgaacc tcaccatggc ggacatgctc ttcttgatca ccctgccac 241 ttggattgtc tactaccaaa accagggcaa ctggatactc cccaaattcc tgtgcaacgt 301 ggctggctgc cttttcttca tcaacaccta ctgctctgtg gccttcctgg gcgtcatcac 361 ttataaccgc ttccaggcag taactcggcc catcaagact gctcaggcca acacccgcaa 421 gcgtggcatc tctttgtcct tggtcatctg ggtggccatt gtgggagctg catcctactt 481 cctcatcctg gactctacca acacagtgcc cgacagtgct ggctcaggca acgtcactcg 541 ctgctttgag cattacgaga agggcagcgt gccagtcctc atcatccaca tcttcatcgt 601 gttcagcttc ttcctggtct tcctcatcat cctcttctgc aacctggtca tcatccgtac 661 cttgctcatg cagccggtgc agcagcagcg caacgctgaa gtcaagcgcc gggcgctgtg 721 gatggtgtgc acggtcttgg cggtgttcat catctgcttc gtgccccacc acgtggtgca 781 gctgccctgg acccttgctg agctgggctt ccaggacagc aaattccacc aggccattaa 841 tgatgcacat caggtcaccc tctgcctcct tagcaccaac tgtgtcttag accctgttat 901 ctactgtttc ctcaccaaga agttccgcaa gcacctcacc gaaaagttct acagcatgcg 961 cagtagccgg aaatgctccc gggccaccac ggatacggtc actgaagtgg ttgtgccatt 1021 caaccagatc cctggcaatt ccctcaaaaa ttagtccttg cttc 1 ttcacgaggg ctggggccag gacccagaca gagacacacg gtcactgcag ctgaagccgc 61 tgcccctgct acaggcacca ccaggaccag ctgatcattc cagcccacag caatggagcc 121 acatgactcc tcccacatgg actctgagtt ccgatacact ctcttcccga ttgtttacag 181 catcatcttt gtgctcgggg tcattgctaa tggctacgtg ctgtgggtct ttgcccgcct 241 gtacccttgc aagaaattca atgagataaa gatcttcatg gtgaacctca ccatggcgga 301 catgctcttc ttgatcaccc tgccactttg gattgtctac taccaaaacc agggcaactg 361 gatactcccc aaattcctgt gcaacgtggc tggctgcctt ttcttcatca acacctactg 421 ctctgtggcc ttcctgggcg tcatcactta taaccgcttc caggcagtaa ctcggcccat 481 caagactgct caggccaaca cccgcaagcg tggcatctct ttgtccttgg tcatctgggt 541 ggccattgtg ggagctgcat cctacttcct catcctggac tccaccaaca cagtgcccga 601 cagtgctggc tcaggcaacg tcactcgctg ctttgagcat tacgagaagg gcagcgtgcc 661 agtcctcatc atccacatct tcatcgtgtt cagcttcttc ctggtcttcc tcatcatcct 721 cttctgcaac ctggtcatca tccgtacctt gctcatgcag ccggtgcagc agcagcgcaa WO 00/09525 1303 PCT/US99/17712 781 cgctgaagtc aagcgccggg cgctgtggat ggtgtgcacg gtcttggcgg tgttcatcat 841 ctgcttcgtg ccccaccacg tggtgcagct gccctggacc cttgctgagc tgggcttcca 901 ggacagcaaa ttccaccagg ccattaatga tgcacatcag gtcaccctct gcctccttag 961 caccaactgt gtcttagacc ctgttatcta ctgtttcctc accaagaagt tccgcaagca 1021 cctcaccgaa aaattctaca gcatgcgcag tagccggaaa tgctcccggg ccaccacgga 1081 tacggtcact gaagtggttg tgccattcaa ccagatccct ggcaattccc tcaaaaatta 1141 gtccctgctt ccaggcctga agtcttctcc tccatgaaac atcatgactg agctggggga 1201 agaagggata tctactgtgg gtctgggcac cacctctgtg gcactggtgg gccattagat 1261 ttggaggcta cctcacctgg gcagggatga tgcagagcca ggctgttgga aaatccagaa 1321 ctcaaatgag ccccttcatc cgcctgtggg cgcatactac agtaactgtg actgatgact 1381 ttatcctgag tcccttaatc ttatggggcc ggaaggaatg tcagggccag gtgcagacct 1441 tgggggaaga ctttaaacca cctagttctc ccactggggc atcqgtctaa agctttgggg 1501 gagtggcccc agtggctcac acctgtaatc ccagcacttt gggaggccga ggtgggcaga 1561 tcatgggtca agagatcgag acatcctggc caacattgta aaaccccatc tctactaaaa 1621 catacaaaaa ttagccgggc atggtgcaca cgcctgtagt cccagctact caggaggctg 1681 aggcaggaga atcgcttgaa cctgggaggc agaggttgca gtgaacctag attgcaccat 1741 tgcactctag cctggcaaca gaggcagatt ccctcctgcc 1 cgggaggcgg aggttgcggt gagctgagat cacgccactg cactccagcc tgggcagcaa 61 gagtgaaact ccatctgaaa aaaaaaaaaa gattcaacat gaacttctga ggggacatca 121 tcattctaac catggcaagg agtcttggaa ctgatgaaat ggaacagtcc cttcttgtcc 181 ctttattaac cagaattttt gtgtggtctt ccaggcacca ccaggaccag ctgatcattc 241 cagcccacag caatggagcc acatgactcc tcccacatgg actctgagtt ccgatacact 301 ctcttcccga ttgtttacag catcatcttt gtgctcgggg tcattgctaa tggctacgtg 361 ctgtgggtct ttgcccgcct gtacccttgc aagaaattca atgagataaa gatcttcatg 421 gtgaacctca ccatggcgga catgctcttc ttgatcaccc tgccactttg gattgtctac 481 taccaaaacc agggcaactg gatactcccc aaattcctgt gcaacgtggc tggctgcctt 541 ttcttcatca acacctactg ctctgtggcc ttcctgggcg tcatcactta taaccgcttc 601 caggcagtaa ctcggcccat caagactgct caggccaaca cccgcaagcg tggcatctct 661 ttgtccttgg tcatctgggt ggccattgtg ggagctgcat cctacttcct catcctggac 721 tccaccaaca cagtgcccga cagtgctggc tcaggcaacg tcactcgctg ctttgagcat 781 tacgagaagg gcagcgtgcc agtcctcatc atccacatct tcatcgtgtt cagcttcttc 841 ctggtcttcc tcatcatcct cttctgcaac ctggtcatca tccgtacctt gctcatgcag 901 ccggtgcagc agcagcgcaa cgctgaagtc acaggccggg cgctgtggat ggtgtgcacg 961 gtcttggcgg tgttcatcat ctgcttcgtg ccccaccacg tggtgcagct gccctggacc 1021 cttgctgagc tgggcttcca ggacagcaaa ttccaccagg ccattaatga tgcacatcag 1081 gtcaccctct gcctccttag caccaactgt gtcttagacc ctgttatcta ctgtttcctc 1141 accaagaagt tccgcaagca cctcaccgaa aagttctaca gcatgcgcag tagccggaaa 1201 tgctcccggg ccaccacgga tacggtcact gaagtggttg tgccattcaa ccagatccct 1261 ggcaattccc tcaaaaatta gtccctgctt ccaggcctga agtcttctcc tccatgaaca 1321 tcatggactg agctggggga agaagggata tctactgtgg tctgggcacc acctctgtgg 1381 gcactggtgg gccattagat ttggaggcta cctcacctgg gcagggatga tggcagacga 1441 ggctgttgga aaatccagaa ctcaaat (2) INFORMATION FOR SEQ ID NO:155: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 827 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:155: 1 ctcctcctgc acaccttccg cacacctccc tcgctctccc acaccactgg caccaggccc 61 cgcacacctg ctcggctgca ggagaatggc tactcatcac acgctgtgga tgggactggt 121 cctgctgggg ctgctgggcg gcctacaggc agcacccgag gcccaggtct ccgtgcagcc 181 caacttccag ccggacaagt tcctggggcg ctggttcagc gcgggcctcg cctccaactc 241 gagctggctc caggagaaga aggcagcgct gtccatgtgc aagtcggtgg tggcccctgc 301 ggcggatggt ggcttcaacc tgacctccac cttcctcagg aaaaaccagt gtgagacccg 361 aaccatgctg ctgcagcccg gggactccct cggctcctac agctaccgga gtccccactg 421 gggcagcacc tactctgtgt cagtggtgga gactgactac gaccactacg ccctgctgta 481 cagccagggc agcaagggcc ccggcgagga cttccgcatg gccaccctct acagccgaac 541 ccagaccccc agggctgagt taaaggagaa atttaccgcc ttctgcaagg cccagggctt 601 cacagaggat tccattgtct tcctgcccca aaccgataag tgcatgacgg aacaatagga 661 ctccccagag ctgaagctgg gaccgcagcc agccaggtga cccctgcgat ctggatgttt 721 ccgctctgtt ccttccccga gcccctgccc cggctccccg ccaaagcacc cctgccccct 781 cgggcttcct cctggctctg cggaataaac tccggaagca agtctgt (2) INFORMATION FOR SEQ ID NO:156: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 2245 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:156: 1ggagcaagag gtggttgggg ggggaccatg gctgacgttt tcccgggcaa cgactccacg 61 gcgtctcagg acgtggccaa ccgcttcgcc cgcaaagggg cgctgaggca gaagaacgtg WO 00/09525 1304 PCT/US99/17712 121 cacgaggtga aggaccacaa attcatcgcg cgcttcttca agcagcccac cttctgcagc 181 cactgcaccg acttcatctg ggggtttggg aaacaaggct tccagtgcca agtttgctgt 241 tttgtggtcc acaagaggtg ccatgaattt gttacttttt cctgtccggg tgcggataag 301 ggacccgaca ctgatgaccc caggagcaag cacaagttca aaatccacac ttacggaagc 361 cccaccttct gcgatcactg tgggtcactg ctctatggac ttatccatca agggatgaaa 421 tgtgacacct gcgatatgaa cgttcacaag caatgcgtca tcaatgtccc cagcctctgc 481 ggaatggatc acactgagaa gagggggcgg atttacctaa aggctgaggt tgctgatgaa 541 aagctccatg tcacagtacg agatgcaaaa aatctaatcc ctatggatcc aaacgggctt 601 tcagatcctt atgtgaagct gaaacttatt cctgatccca agaatgaaag caagcaaaaa 661 accaaaacca tccgctccac actaaatccg cagtggaatg agtcctttac attcaaattg 721 aaaccttcag acaaagaccg acgactgtct gtagaaatct gggactggga tcgaacaaca 781 aggaatgact tcatgggatc cctttccttt ggagtttcgg agctgatgaa gatgccggcc 841 agtggatggt acaagttgct taaccaagaa gaaggtgagt actacaacgt acccattccg 901 gaaggggacg aggaaggaaa catggaactc aggcagaaat tcgagaaagc caaacttggc 961 cctgctggca acaaagtcat cagtccctct gaagacagga aacaaccttc caacaacctt 1021 gaccgagtga aactcacgga cttcaatttc ctcatggtgt tgggaaaggg gagttttgga 1081 aaggtgatgc ttgccgacag gaagggcaca gaagaactgt atgcaatcaa aatcctgaag 1141 aaggatgtgg tgattcagga tgatgacgtg gagtgcacca tggtagaaaa gcgagtcttg 1201 gccctgcttg acaaaccccc gttcttgacg cagctgcact cctgcttcca gacagtggat 1261 cggctgtact tcgtcatgga atatgtcaac ggtggggacc tcatgtacca cattcagcaa 1321 gtaggaaaat ttaaggaacc acaagcagta ttctatgcgg cagagatttc catcggattg 1381 ttctttcttc ataaaagagg aatcatttat agggatctga agttagataa cgtcatgttg 1441 gattcagaag gacatatcaa aattgctgac tttgggatgt gcaaggaaca catgatggat 1501 ggagtcacga ccaggacctt ctgtgggact ccagattata tcgccccaga gataatcgct 1561 tatcagccgt atggaaaatc tgtggactgg tgggcctatg gcgtcctgtt gtatgaaatg 1621 cttgccgggc agcctccatt tgatggtgaa gatgaagacg agctatttca gtctatcatg 1681 gagcacaacg tttcctatcc aaaatccttg tccaaggagg ctgtttctat ctgcaaagga 1741 ctgatgacca aacacccagc caagcggctg ggctgtgggc ctgaggggga gagggacgtg 1801 agagagcatg ccttcttccg gaggatcgac tgggaaaaac tggaqaacag ggagatccag 1861 ccaccattca agcccaaagt gtgtggcaaa ggagcagaga actttgacaa gttcttcaca 1921 cgaggacagc ccgtcttaac accacctgat cagctggtta ttgctaacat agaccagtct 1981 gattttgaag ggttctcgta tgtcaacccc cagtttgtgc accccatctt acagagtgca 2041 gtatgaaact caccagcgag aacaaacacc tccccagccc ccagccctcc ccgcagtgga 2101 agtgaatcct taaccctaaa attttaaggc cacggcttgt gtctgattcc atatggaggc 2161 ctgaaaattg tagggttatt agtccaaatg tgatcaactg ttcagggtct ctctcttaca 2221 accaagaaca ttatcttagt ggaag (2) INFORMATION FOR SEQ ID NO:157: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 636 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (0) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:157: 1 cttatcacag ttcaagtgat ttccagaagt tccagggctt ctgagagacc atcaagggaa 61 ctttaacaac ttgacaaatg tccttgaagt aagatgcctc atctttaggg aaaaatgggg 121 tttggatttc tgcttaggca aagtctcctg cagttcatcc ttctctgtcc tcttcttgct 181 tcaggcttgg ggaccgtccc tgctgtcccc actgtggtgg caatcaggac ctaaggtgaa 241 gcaaacttga agttctatct gacaagttta ggcagtaaga gaaggaggga aatcggagca 301 aagctccctc actttatcgt tgagaaactg gcatctggaa agaagaagga atttgcccaa 361 agtcagtcag ctgggataaa aacctgggtg tcctgtccag aaagtgcagg gtgctttctg 421 ctctgtagca aggcagcaga catctctgag ccaggcccac caacaggccc ttatctggtg 481 gttggatcat gatcccattt tgcttggaca tgctctcagg aagataaaaa ccatggagaa 541 acaccaggcc attgacaaat gatctgagac aactttagaa aacaatgtag gatgaatgga 601 aagagaaaga aaggaaagaa aaaaaaaaaa aaaagg (2) INFORMATION FOR SEQ ID NO:158: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 2574 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:158: 1cagagccggc gcaggggaag cgcccggggc cccgggtgca gcagcgcccg ccgcctcccg 61 ggcctccccg gcccgcaacc cggggtcccg ggccccgggg ccggcacctc tcgggctccg 121 gctccccgcg cgcaagatgg ctgacccggc tgcggggccg ccgccgagcg agggcgagga 181 gagcaccgtg cgcttcgccc gcaaaggcgc cctccggcag aagaacgtgc atgaggtcaa 241 gaaccacaaa ttcaccgccc gcttcttcaa gcagcccacc ttctgcagcc actgcaccga 301 cttcatctgg ggcttcggga agcagggatt ccagtgccaa gtttgctgct ttgtggtgca 361 caagcggtgc catgaatttg tcacattctc ctgccctggc gctgacaagg gtccagcctc 421 cgatgacccc cgcagcaaac acaagtttaa gatccacacg tactccagcc ccacgttttg 481 tgaccactgt gggtcactgc tgtatggact catccaccag gggatgaaat gtgacacctg 541 catgatgaat gtgcacaagc gctgcgtgat gaatgttccc agcctgtgtg gcacggacca 601 cacggagcac cgcggccgca tctacatcca ggcccacatc gacagggacg tcctcattgt WO 00/09525 1305 PCT/US99/17712 661 cctcgtaaga gatgctaaaa accttgtacc tatggacccc aatggcctgt cagatcccta 721 cgtaaaactg aaactgattc ccgatcccaa aagtgagagc aaacagaaga ccaaaaccat 781 caaatgctcc ctcaaccctg agtggaatga gacatttaga tttcagctga aagaatcgga 841 caaagacaga agactgtcag tagagatttg ggattgggat ttgaccagca ggaatgactt 901 catgggatct ttgtcctttg ggatttcga acttcagaag gccagtgttg atggctggtt 961 taagttactg agccaggagg aaggcgagta cttcaatgtg cctgtgccac cagaaggaag 1021 tgaggccaat gaagaactgc ggcagaaatt tgagagggcc aagatcagtc agggaaccaa 1081 ggtcccggaa gaaaagacga ccaacactgc ctccaaattt gacaacaatg gcaacagaga 1141 ccggatgaaa ctgaccgatt ttaacttcct aatggtgctg gggaaaggca gctttggcaa 1201 ggtcatgctt tcagaacgaa aaggcacaga tgagctctat gctgtgaaga tcctgaagaa 1261 ggacgttgtg atccaagatg atgacgtgga gtgcactatg gtggagaagc gggtgttggc 1321 cctgcctggg aagccgccct tcctgaccca gctccactcc tgcttccaga ccatggaccg 1381 cctgtacttt gtgatggagt acgtgaatgg gggcgacctc atgtatcaca tccagcaagt 1441 cggccggttc aaggagcccc atgctgtatt ttacgctgca gaaattgcca tcggtctgtt 1501 cttcttacag agtaagggca tcatttaccg tgacctaaaa cttgacaacg tgatgctcga 1561 ttctgaggga cacatcaaga ttgccgattt tggcatgtgt aaggaaaaca tctgggatgg 1621 ggtgacaacc aagacattct gtggcactcc agactacatc gcccccgaga taattgctta 1681 tcagccctat gggaagtccg tggattggtg ggcatttgga gtcctgctgt atgaaatgtt 1741 ggctgggcag gcaccctttg aaggggagga tgaagatgaa ctcttccaac ccatcatgga 1801 acacaacgta gcctatccca agtctatgtc caaggaagct gtggccatct gcaaagggct 1861 gatgaccaaa cacccaggca aacgtctggg ttgtggacct gaaggcgaac gtgatatcaa 1921 agagcatgca tttttccggt atattgattg ggagaaactt gaacgcaaag agatccagcc 1981 cccttataag ccaaaagcta gagacaagag agacacctcc aacttcgaca aagagttcac 2041 cagacagcct gtggaactga cccccactga taaactcttc atcatgaact tggaccaaaa 2101 tgaatttgct ggcttctctt atactaaccc agagtttgtc attaatgtgt aggtgaatgc 2161 aaactccatc gttgagcctg gggtgtaaga cttcaagcca agcgtatgta tcaattctag 2221 tcttccagga ttcacggtgc acatgctggc attcaacatg tggaaagctt gtcttagagg 2281 cctttcttgt atgtgtagct tgctagtttg ttttctacat ttgaaaatgt ttagtttaga 2341 ataagcgcat tatccaatta tagaggtaca attttccaaa cttccagaaa ctcatcaaat 2401 gaacagacaa tgtcaaaact actgtgtctg ataccaaaat gcttcagtat ttgtaatttt 2461 tcaagtcaga agctgatgtt cctggtaaaa gtttttacag ttattctata atatcttctt 2521 tgaatgctaa gcatgagcga tatttttaaa aattgtgagt aagcttcgga attc (2) INFORMATION FOR SEQ ID NO:159: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 3321 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:159: 1cagagccggc gcaggggaag cgcccggggc cccgggtgca gcagcgcccg ccgcctcccg 61 ggcctccccg gcccgcagcc cggggtcccg ggccccgggg ccggcacctc tcgggctccg 121 gctccccgcg cgcaagatgg ctgacccggc tgcggggccg ccgccgagcg agggcgagga 181 gagcaccgtg cgcttcgccc gcaaaggcgc cctccggcag aagaacgtgc atgaggtcaa 241 gaaccacaaa ttcaccgccc gcttcttcaa gcagcccacc ttctgcagcc actgcaccga 301 cttcatctgg ggcttcggga agcagggatt ccagtgccaa gtttgctgct ttgtggtgca 361 caagcggtgc catgaatttlg tcacattctc ctgccctggc gctgacaagg gtccagcctc 421 cgatgacccc cgcagcaaac acaagtttaa gatccacacg tactccagcc ccacgttttg 481 tgaccactgt gggtcactgc tgtatggact catccaccag gggatgaaat gtgacacctg 541 catgatgaat gtgcacaagc gctgcgtgat gaatgttccc agcctgtgtg gcacggacca 601 cacggagcgc cgcggccgca tctacatcca ggcccacatc gacagggacg tcctcattgt 661 cctcgtaaga gatgctaaaa accttgtacc tatggacccc aatggcctgt cagatcccta 721 cgtaaaactg aaactgattc ccgatcccaa aagtgagagc aaacagaaga ccaaaaccat 781 caaatgctcc ctcaaccctg agtggaatga gacatttaga tttcagctga aagaatcgga 841 caaagacaga agactgtcag tagagatttg ggattgggat ttgaccagca ggaatgactt 901 catgggatct ttgtcctttg ggatttctga acttcagaag gccagtgttg atggctggtt 961 taagttactg agccaggagg aaggcgagta cttcaatgtg cctgtgccac cagaaggaag 1021 tgaggccaat gaagaactgc ggcagaaatt tgagagggcc aagatcagtc agggaaccaa 1081 ggtcccggaa gaaaagacga ccaacactgt ctccaaattt gacaacaatg gcaacagaga 1141 ccggatgaaa ctgaccgatt ttaacttcct aatggtgctg gggaaaggca gctttggcaa 1201 ggtcatgctt tcagaacgaa aaggcacaga tgagctctat gctgtgaaga tcctgaagaa 1261 ggacgttgtg atccaagatg atgacgtgga gtgcactatg gtggagaagc gggtgttggc 1321 cctgcctggg aagccgccct tcctgaccca gctccactcc tgcttccaga ccatggaccg 1381 cczgtacttt gtgatggagt acgtgaatgg gggcgacctc atgtatcaca tccagcaagt 1441 cggccggttc aaggagcccc atgctgtatt ttacgctgca gaaattgcca tcggtctgtt 1501 cttcttacag agtaagggca tcatttaccg tgacctaaaa cttgacaacg tgatgctcga 1561 ttctgaggga cacatcaaga ttgccgattt tggcatgtgt aaggaaaaca tctgggatgg 1621 ggtgacaacc aagacattct gtggcactcc agactacatc gcccccgaga taattgctta 1681 tcagccctat gggaagtccg tggattggtg ggcatttgga gtcctgctgt atgaaatgtt 1741 ggctgggcag gcaccctttg aaggggagga tgaagatgaa ctcttccaat ccatcatgga 1801 acacaacgta gcctatccca agtctatgtc caaggaagct gtggccatct gcaaagggct 1861 gatgaccaaa cacccaggca aacgtctggg ttgtggacct gaaggcgaac gtgatatcaa _WO 00/09525 1306 PCT/US99/17712 1921 agagcatgca tttttccggt atattgattg ggagaaactt gaacgcaaag agatccagcc 1981 cccttataag ccaaaagctt gtgggcgaaa tgctgaaaac ttcgaccgat ttttcacccg 2041 ccatccacca gtcctaacac ctcccgacca ggaagtcatc aggaatattg accaatcaga 2101 attcgaagga ttttcctttg ttaactctga atttttaaaa cccgaagtca agagctaagt 2161 agatgtgtag atctccgtcc ttcatttctg tcattcaagc tcaacggcta ttgtggtgac 2221 atttttatgt ttttcattgc caagttgcat ccatgtttga ttttctgatg agactagagt 2281 gacagtgttt cagaacccaa atatcctcag gtagtttgga gcatctctat gagatgggat 2341 tatgcagatg gcctatggaa aatgcagctg cataattaac acattatcaa agtcctctta 2401 caatttattt tccgcagcat gtcagctaag tagacccaat ggggagagaa aatgcctgct 2461 ttctttccct ctttttctgc actgccatat tcacccccaa ccatccaatc tgtggataat 2521 tggatgttag cggtactctt ccacttccgg tcctggagct tggcttgtat ccaagtgtat 2581 ggttgctttg cctaagagga atccctctat ttcacctgtt ctggaggcac cagaccttga 2641 aaagaacatg ctcaaaataa aatgttatct gttatttttg taaactcaaa gttaagatga 2701 tcaaagttct aaaattccaa gaatgtgctt ttagacggtc tcaatctaaa agcacttcaa 2761 ggggtcaaag ggcaaccagc ttggtgctac ctcagtgttg tagtttctga tactttatgt 2821 ctttgctcac cctcatcccc aaactacttg aaaagggcat ttggcaccac tctctgaaac 2881 aacacagtca ctctagcaag gcccccaaag ggccctggtt ttacattaca tttcaaactt 2941 tatttgcttt ggggttttgt ttctgttgtt gttcaaatgc aaaaaaaaga aaaaaaaaag 3001 aaaaaaaaag gtgactcaca ttgttacaca tgctttaaaa tatgtgttca aatgttatta 3061 accacaatga cgacctgttt tgatttaacc aagaagacgg ctgcggagcc tagcagactc 3121 aggcctgtgg gaatgggatt tgttacaaat ctaggtttgt tactggcttc agaaagctaa 3181 ttaagtgctc tgaaaaagac accgtttctt gaaacaaaga tggttgtatt cctcactttg 3241 atgttgtttt gcaagatgtt tgtggaaatg ttcatttgta tctggatctc tgttatgtgc 3301 catttttctt ctagcatcga g (2) INFORMATION FOR SEQ ID NO:160: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 621 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:160: 1 gtccttcatt ccttccacaa ctatttatcc agcaccgttt ctgggcacag ggctccagcg 61 atggtcccaa caggtacaat gacctctggg gaccaagttc agttcttggt gagttctcca 121 gtgcctctcg atgtaggactg aaccgttggc atgctccact gacgctggct ccttctgttg 181 tatctcttgg ctccaggacc cccgcagcaa acacaagttt aagatccaca cgtactccag 241 ccccacgttt tgtgaccact gtgggtcact gctgtatgga ctcatccacc aggggatgaa 301 atgtgacagt aagtactttc tctctctggg ggcatctgct gatggcagaa gcaatgggaa 361 gggctgcttc cacttggttt ggggtccagg tctgccatac attcccccct gtcctcgttg 421 gggctggtgt accagttatc tgttgctgca taatgatcct cccaccccaa aacactgtga 481 ctgaagacaa taaacatttt tttagctcat gactctgcaa ggcagtcctt tgaatctggg 541 ctggcctcag ctgatgtcac gcatgttcatc aaagcatgaa ctcatggttc atggtggatt 601 agcagatgga ggtgggctgg g (2) INFORMATION FOR SEQ ID NO:1617: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1559 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:161: 1 acatcaagga gacgagtcct ggttggatag taatgtcttt aacacccctc tagcatttat 61 taatttcctc tcttaacaaa taaaagatgc ccttcagtca gatgcttagg acagatgacg 121 cacctagaga tattttaata atgtagatac tcttgctgtt caaactcaga ccaaaatgac 181 gataggcttt tttggccccc agagggtgca caaatacgac cagaatttgt gaagacgagt 241 cagaaatgaa tgaaatttgg aaaaatattg atctactgaa atccttcctc cccacactat 301 tagccctatg ttacagttgg ggaaacggag tcgttttgca gaggggatgg acagaaggta 361 gggagttctc ttccaaacgt gcaggaggca agcaaagcca agaatcttct ctgtggtgag 421 ttagagacat ataaaataaa gatcgctcct cccctacctc tgcagaacgt gtgtgtgtat 481 gtgtgtgtaa gtgtgtgcgg ccacaagcct ttccgaatga gtgacagcgg gagcccatcc 541cctccaggaga cgcgtgcaga atgaccaatg ggatggatgg gggtggatgg gtaccagtct 601 ccgcagaggc cggggtggga attcgctgcg ccccacccct tccacccgct ccccttcgcc 661 ccgcaggtct ttccactctc gctcccccc tgggcacatc tcctgaacgc agccccgggg 721 gccgaggacg gggtggggtg gggggcgagg ctcgggtccg acgaccccgg gctgcggtcc 781 cggcgctgca gagctgcggc tgtgcacgct tagccgcgag gcccgcggta gcccgggcgc 841 cgatatgtaa agcagccggc agcgctgggc ggggcctggg cgcgactgca aatgaggagg 901 gcgcgggctg gcccgggggc tccgcctccc tcccccgcag ctggggccag cggctgccaa 961 gcgcactggt cgagcggcag cagctgggcg aggtgacagc cccggctccg cgcgccggcc 1021 gccagagccg gcgcagggga agcgcccgcg gccccgggtg cagcagcggc cgccgcctcc 1081 cgcgcctccc cggcccgcag cccgcggtcc cgcgccccgg ggccggcacc tctcgggctc 1141 cggctccccg cgcgcaagat ggctgacccg gctgcggggc cgccgccgag cgagggcgag WO 00/09525 1307 PCT/US99/17712 1201 gagagcaccg tgcgcttcgc ccgcaaaggc gccctcaggc agaagaacgt gcatgaggtc 1261 aagaaccaca aattcaccgc ccgcttcttc aagcagccca ccttctgcag ccactgcacc 1321 gacttcatct ggtgaccccc caggcactcc ggccccaggc cacgccgcgc caggaccccc 1381 tctccgcgcc ctctgcgccc tccgcaccct ggaccccgcg tccccggact ccccgctccg 1441 gaccctgctg cccgggactc ccggatggac agtcctagcc gttgccctgt ccccaccctg 1501 gtcccagacg ggccgccgcg ggcgcctcct gccctctcct gctctcaggc gcctctaga (2) INFORMATION FOR SEQ ID NO:162: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 2510 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:162: 1 gtcgactgca ggtcaacgga cacatcaagg agagagtcct ggttggatag taatgtcttt 61 aacacccctc tagcatttat taatttcctc tcttaacaaa taaaagatga cttcagttga 121 agatccttag gacagatgac ggcacctgga gatattttaa taatgtagat accctcttgc 181 tgttcaaact cagaccaaaa gagatggctt tttttccccc agagggtgca caaatacgac 241 agaatttgtg aagacgagtc agaaatgaat gaaatttgga aaaatattga tctactgaaa 301 tccttcctcc ccacactatt agccctatgt tacagttggg gaaacggagt cgttttgcag 361 aggggatgga cagaaggtag ggagttctct tccaacgtgc aggaggcaag caaagccaag 421 catcttctct gtggtggagt tagagacata taaaataaga tcgctcctcc cctacctctg 481 cagaacgtgt gtgtgtatgt gtgtgtaacg tgtgtgcggc cacaagcctt tccgaatgag 541 tgacagcggg agcccatccc tccaggagac gcgtgcagaa tgaccaatgg gatggatggg 601 ggtggatggg taccgtctcc gcgaggccgg ggtggaattc gctgcgcccc accccttcca 661 cccgctcccc ttcgccccgt aggtctttcc actctcgctc ctcccctggg cacatctcct 721 gaacgcagcc ccgggggccg aggacggggc ggggtggggg gcgaggctcg ggtccgacga 781 ccccgggctg cggtcccggc gctgcagagc tgcggctgtg cacgcttagc cgcgaggccc 841 gcggtagccc gggcgccgat atgtaaagca gctggcagcg ctgggcgggg cctgggcgcg 901 atgcaaatga ggagggcggg gctggcccgg ggctccgcct ccctcccccg cagctggggc 961 cagcggtgcc aagcgcagct ggacgagcgg cagcagctgg gcgagtgaca gccccggctc 1021 cgcgcgccgc ggccgccaga gccggcgcag gggaagcgcc cgcggccccg ggtgcagcag 1081 cggccgccgc ctcccgcgcc tccccggccc gcagcccgcg gtcccgcggc cccggggccg 1141 gcacctctcg ggctccggct ccccgcgcgc aagatggctg acccggctgc ggggccgccg 1201 ccgagcgagg gcgaggagag caccgtgcgc ttcgcccgca aaggcgccct caggcagaag 1261 aacgtgcatg aggtcaagaa ccacaaattc accgcccgct tcttcaagca gcccaccttc 1321 tgcagccact gcaccgactt catctggtgg agcgcgcgcg caaggcacct tcccgggccc 1381 ccgaggcagc gccgcgccaa gggaccccct ctccgccctc tgcgccctcc gcaccctgga 1441 ccccgcgtcc ccggactccc cgctccggac cctgctgccg ggactcccgg atggacagtc 1501 ctgccgttgc cctgtcccca ccctggtccc aggacggggg cgcctcctgc cctctcctgc 1561 tctcaggcgc ctctagagcg cccaggggca gcgtcgcggg cgcctttgct ccacctgact 1621 aggagcgcgc ggggtctgtg cctgccctgg agggcagcgc ctcgggtgct ctccgacccg 1681 gggttcccta tctctccgcc tgcttccggg cgcgaggagc cctcgccccc caccccttgt 1741 ttccgggggg ggggggcggc gccctgggtg tccttctcta tctctgcggg catgggacat 1801 cctttctcac tcctctgtgc ctcggcagcg ccctgtgtta tctcccattg ccctccccga 1861 gggcctggtt cccctttcca ctcctcggtc acatcactgc gggccccttt cttccccagt 1921 ccctccagta gtggggcatc ctttcctcct tcccagtccc cctcccagag gacaccaccg 1981 ccgcggggtc actctcgccc tccctctgaa tgcgtcttta tctcttctct tttccgaggg 2041 tgctcggggc atctatgggt acatctgtcg cctgccttca gcccctaccc cgacggaaac 2101 gctccccact atcccgccac ctggtggtcg cagcctcctc tcttctgcag gagtgaaggc 2161 agatcggggt tacagccgag ctcccaccta cccccacaaa ggcggaagac tcttgggcac 2221 ccgcctgtgg ctgggagttt gcacctgggg tacagaggca gggaggaagg cgggtgactc 2281 tgtgggtaac tagctggagg ctgggccccc gggctgcctg acatacacct ccttctgctt 2341 ttgcaggggc ttcgggaagc agggattcca gtgccaaggt aggctctggg gctttgggga 2401 tgctatttgt gggaagagag ggtgaaaaat actttataga agaagttact gagttaggca 2461 gagagtgaaa gaatcacgtt ggtcggagtg acctcccagg ctaggaattc (2) INFORMATION FOR SEQ ID NO:163: (i( SEQUENCE CHARACTERISTICS: (A) LENGTH: 2163 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi(SEQUENCE DESCRIPTION: SEQ ID NO:163: aaagcgacca tgtatcctga gtggaagtcg acgttcgatg cccacatcta tgaggggcgc 61 gtcatccaga ttgtgctaag gcgggcagca gaggagccag tgtctgaggt gaccgtgggt 121 gtgtcggtgc tggccgagcg ctgcaagaag aacaatggca aggctgagtt ctggctggac 181 ctgcagcctc aggccaaggt gttgatgtct gttcagtatt tcctggagga cgtggattgc 241 aaacagtcta tgcgcagtga ggacgaggcc aagttcccaa cgatgaaccg ccgcggagcc 301 atcaaacagg ccaaaatcca ctacatcaag aaccatgagt ttatcgccac cttctttggg 361 caacccacct tctgttctgt gtgcaaagac tttgtctggg gcctcaacaa gcaaggctac 421 aaatgcaggc aatgtaacgc tgccatccac aagaaatgca tcgacaagat catcggcaga 481 tgcactggca ccgcggccaa cagccgggac actatattcc agaaagaacg cttcaacac WO 00/09525 1308 PCT/US99/17712 541 gacatgccgc accgcttcaa ggttcacaac tacatgagcc ccaccttctg tgaccactgc 601 ggcagcctgc tctggggact ggtgaagcag ggattaaagt gtgaagactg cggcatgaat 661 gtgcaccata aatgccggga gaaggtggcc aacctctgcg gcatcaacca gaagcttttg 721 gctgaggcct tgaaccaagt cacccagaga gcctcccgga gatcagactc agcctcctca 781 gagcctgttg ggatatatca gggtttcgag aagaagaccg gagttgctgg ggaggacatg 841 caagacaaca gtgggaccta cggcaagatc tgggagggca gcagcaagtg caacatcaac 901 aacttcatct tccacaaggt cctgggcaaa ggcagcttcg ggaaggtgct gcttggagag 961 ctgaagggca gaggagagta ctttgccatc aaggccctca agaaggatgt ggtcctgatc 1021 gacgacgacg tggagtgcac catggttgag aagcgggtgc tgacacttgc cgcagagaat 1081 ccctttctca cccacctcat ctgcaccttc cagaccaagg accacctgtt Ctttgtgatg 1141 gagttcctca acggggggga cctgatgtac cacatccagg acaaaggccg ctttgaactc 1201 taccgtgcca cgttttatgc cgctgagata atgtgtggac tgcagtttct acacagcaag 1261 ggcatcattt acagggacct caaactggac aatgtgctgt tggaccggga tggccacatc 1321 aagattgccg actttgggat gtgcaaagag aacatattcg gggagagccg ggccagcacc 1381 ttctgcggca cccctgacta tatcgcccct gagatcctac agggcctgaa gtacacattc 1441 tctgtggact ggtggtcttt cggggtcctt ctgtacgaga tgctcattgg ccagtccccc 1501 ttccatggtg atgatgagga tgaactcttc gagtccatcc gtgtggacac gccacattat 1561 ccccgctgga tcaccaagga gtccaaggac atcctggaga agctctttga aagggaacca 1621 accaagaggc tgggagtgac gggaaacatc aaaatccacc ccttcttcaa gaccataaac 1681 tggactctgc tggaaaagcg gaggttggag ccacccttca ggcccaaagt gaagtcaccc 1741 agagactaca gtaactttga ccaggagttc ctgaacgaga aggcgcgcct ctcctacagc 1801 gacaagaacc tcatcgactc catggaccag tctgcattcg ctggcttctc ctttgtgaac 1861 cccaaattcg agcacctcct ggaagattga ggttcctgga cagatcaggc tagccctgcc 1921 ctccacccac acctgcccgc tccccacgat aagcaccagt gggactgtgg tgacttctgc 1981 tgctggcccc gcccctgccc ccagagcgtc cttggctgcc gtctggccgg gctctcatgg 2041 tacttcctct gtgaactgtg tgtgaatctg cttttcctct gccttcggag ggaaattgta 2101 aatcctgtgt ttcattactt gaatgtagtt atctattgaa aatatacttt agagcacaat 2161 gga (2) INFORMATION FOR SEQ ID NO:164: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 2104 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:164: 1 tgccgccgcg acccttggcg cctgcccctg caacgggagc cccactgcag gccccaccat 61 ggcgccgttc ctgcgcatcg ccttcaactc ctatgagctg ggctccctgc aggccgagga 121 cgaggcgaac cagcccttct gtgccgtgaa gatgaaggag gcgctcagca cagagcgtgg 181 gaaaacactg gtgcagaaga agccgaccat gtatcctgag tggaagtcga cgttcgatgc 241 ccacatctat gaggggcgcg tcatccagat tgtgctaatg cgggcagcag aggagccagt 301 gtctgaggtg accgtgggtg tgtcggtgct ggccgagcgc tgcaagaaga acaatggcaa 361 ggctgagttc tggctggacc tgcagcctca ggccaaggtg ttgatgtctg ttcagtattt 421 cctggaggac gtggattgca aacaatctat gcgcagtgag gacgaggcca agttcccaac 481 gacgaaccgc cgcggagcca tcaaacaggc caaaatccac tacatcaaga accatgagtt 541 tatcgccacc ttctttgggc aacccacctt ctgttctgtg tgcaaagact ttgtctgggg 601 cctcaacaag caaggctaca aatgcaggca atgtaacgct gccatccaca agaaatgcat 661 cgacaagatc atcggcagat gcactggcac cgcggccaac agccgggaca ctatattcca 721 gaaagaacgc ttcaacatcg acatgccgca ccgcttcaag gttcacaact acatgagccc 781 caccttctgt gaccactgcg gcagcctgct ctggggactg gtgaagcagg gattaaagtg 841 tgaagactgc ggcatgaatg tgcaccataa atgccgggag aaggtggcca acctctgcgg 901 catcaaccag aagcttttgg ctgaggcctt gaaccaagtc acccagagag cctcccggag 961 atcagactca gcctcctcag agcctgttgg gatatatcag ggtttcgaga agaagaccgg 1021 agttgctggg gaggacatgc aagacaacag tgggacctac ggcaagatct gggagggcag 1081 cagcaagtgc aacatcaaca acttcatctt ccacaaggtc ctgggcaaag gcagcttcgg 1141 gaaggtgctg cttggagagc tgaagggcag aggagagtac tctgccatca aggccctcaa 1201 gaaggatgtg gtcctgatcg acgacgacgt ggagtgcacc atggttgaga agcgggtgct 1261 gacacttgcc gcagagaatc cctttctcac ccacctcatc tgcaccttcc agaccaagga 1321 ccacctgttc tttgtgatgg agttcctcaa cgggggggac ctgatgtacc acatccagga 1381 caaaggccgc tttgaactct accgtgccac gttttatgcc gctgagataa tgtgtggact 1441 gcagtttcta cacagcaagg gcatcattta cagggacctc aaactggaca atgtgctgtt 1501 ggaccgggat ggccacatca agattgccga ctttgggatg tgcaaagaga acatattcgg 1561 ggagagccgg gccagcacct tctgcggcac ccctgactat atcgcccctg agatcctaca 1621 gggcctgaag tacacattct ctgtggactg gtggtctttc ggggtccttc tgtacgagat 1681 gctcattggc cagtccccct tccatggtga tgatgaggat gaactcttcg agtccatccg 1741 tgtggacacg ccacattatc cccgctggat caccaaggag tccaaggaca tcctggagaa 1801 gctctttgaa agggaaccaa ccaagaggct gggaatgacg ggaaacatca aaatccaccc 1861 cttcttcaag accataaact ggactctgct ggaaaagcgg aggttggagc cacccttcag 1921 gcccaaagtg aagtcaccca gagactacag taactttgac caggagctcc tgaacgagaa 1981 ggcgcgcctc tcctacagcg acaagaacct catcgaccc atggaccagt ctgcattcgc 2041 tggcttctcc tttgtgaacc ccaaattcga gcacctcctg gaagatcgag gttcctggac 2101 agat WO 00/09525 1309 PCT/US99/17712 (2) INFORMATION FOR SEQ ID NO:165: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 2146 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:165: 1 cccaagatgg aagggagcgg cggccgcgtc cgcctcaagg cgcattacgg gggggacatc 61 ttcatcacca gcgtggacgc cgccacgacc ttcgaggagc tctgtgagga agtgagagac 121 atgtgtcgtc tgcaccagca gcacccgctc accctcaagt gggtggacag cgaaggtgac 181 ccttgcacgg tgtcctccca gatggagctg gaagaggctt tccgcctggc ccgtcagtgc 241 agggatgaag gcctcatcat tcatgttttc ccgagcaccc ctgagcagcc tggcctgcca 301 tgtccgggag aagacaaatc tatctaccgc cggggagcca gaagatggag gaagctgtac 361 cgtgccaacg gccacctctt ccaagccaag cgctttaaca ggagagcgta ctgcggtcag 421 tgcagcgaga ggatatgggg cctcgcgagg caaggctaca ggtgcatcaa ctgcaaactg 481 ctggtccata agcgctgcca cggcctcgtc ccgctgacct gcaggaagca tatggattct 541 gtcatgcctt cccaagagcc tccagtagac gacaagaacg aggacgccga ccttccttcc 601 gaggagacag atggaattgc ttacatttcc tcatcccgga agcatgacag cattaaagac 661 gactcggagg accttaagcc agttatcgat gggatggatg gaatcaaaat ctctcagggg 721 cttgggctgc aggactttga cctaatcaga gtcatcgggc gcgggagcta cgccaaggtt 781 ctcctggtgc ggttgaagaa gaatgaccaa atttacgcca tgaaagtggt gaagaaagag 841 ctggtgcatg atgacgagga tattgactgg gtacagacag agaagcacgt gtttgagcag 901 gcatccagca accccttcct ggtcggatta cactcctgct tccagacgac aagtcggttg 961 ttcctggtca ttgagtacgt caacggcggg gacctgatgt tccacatgca gaggcagagg 1021 aagctccctg aggagcacgc caggttctac gcggccgaga tctgcatcgc cctcaacttc 1081 ctgcacgaga gggggatcat ctacagggac ctgaagctgg acaacgtcct cctggatgcg 1141 gacgggcaca tcaagctcac agactacggc atgtgcaagg aaggcctggg ccctggtgac 1201 acaacgagca ctttctgcgg aaccccgaat tacatcgccc ccgaaatcct gcggggagag 1261 gagtacgggt tcagcgtgga ctggtgggcg ctgggagtcc tcatgtttga gatgatggcc 1321 gggcgctccc cgttcgacat catcaccgac aacccggaca tgaacacaga ggactacctt 1381 ttccaagtga tcctggagaa gcccatccgg atcccccggt tcctgtccgt caaagcctcc 1441 catgttttaa aaggattttt aaataaggac cccaaagaga ggctcggctg ccggccacag 1501 actggatttt ctgacatcaa gtcccacgcg ttcttccgca gcatagactg ggacttgctg 1561 gagaagaagc aggcgctccc tccattccag ccacagatca cagacgacta cggtctggac 1621 aactttgaca cacagttcac cagcgagccc gtgcagctga ccccagacga tgaggatgcc 1681 ataaagagga tcgaccagtc agagttcgaa ggctttgagt atatcaaccc attattgctg 1741 tccaccgagg agtcggtgtg aggccgcgtg cgtctctgtc gtggacacgc gtgattgacc 1801 ctttaactgt atccttaacc accgcatatg catgccaggc tgggcacggc tccgagggcg 1861 gccagggaca gacgcttgcg ccgagaccgc agagggaagc gtcagcgggc gctgctggga 1921 gcagaacagt ccctcacacc tggcccggca ggcagcttcg tgctggagga acttgctgct 1981 gtgcctgcgt cgcggcggat ccgcggggac cctgccgagg gggctgtcat gcggtttcca 2041 aggtgcacat tttccacgga aacagaactc gatgcactga cctgctccgc caggaaagtg 2101 agcgtgtagc gtcctgagga ataaaatgct ccgatgaaaa aaaaaa (2) INFORMATION FOR SEQ ID NO:166: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1423 base pairs (t) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:166: gggccggcgg cggcggcgac tctggacgcg agccgggccc ttcccgtgga tcgccccagc 61 tgcggcgggc gtcgcggccg cccccgggtg gcacttccgt gtgccgcggc gccggagccc 121 gaggcggctg tagcccacat ctcccgagcg acccccggcg cccgcccgcc gcgcggaggc 181 ccgggccaca cctcactggc cgcttggccc atcccagtca gcgccgcgcc gaaccccgtc 241 cgcgcgcgcc ggggagcggc gcccccgccg ctgccgccgc gacccttggc gcctgcccct 301 gcaacgggag ccccactgca ggccccacca tggcgccgtt cctgcgcatc gccttcaact 361 cctatgagct gggctccctg caggccgagg acgaggcgaa ccagcccttc tgtgccgtga 421 agatgaagga ggcgctcagc acagagcgtg ggaaaacact ggtgcagaag aagccgacca 481 tgtatcctga gtggaagtcg acgttcgatg cccacatcta tgaggggcgc gtcatccaga 541 ttgtgctaat gcgggcagca gaggagccag tgtctgaggt gaccgtgggt gtgtcggtgc 601 tggccgagcg ctgcaagaag aacaatggca aggctgagtt ctggctggac ctgcagcctc 661 aggccaaggt gttgatgtct gttcaggatt tcctggagga cgtggattgc aaacagtcta 721 tgcgcagtga ggacgaggcc aagttcccaa cgatgaaccg ccgcggagcc atcaaacagg 781 ccaaaatcca ctacatcaag aaccatgagt ttatcgccac cttctttggg caacccacct 841 tctgttctgt gtgcaaagac tttgtctggg gcctcaacaa gcaaggctac aaatgcaggc 901 aatgtaacgc tgccatccac aagaaatgca tcgacaagag catcggcaga tgcactggca 961 ccgcggccaa cagccgggac actatattcc agaaagaacg cttcaacatc gacatgccgc 1021 accgcttcaa ggttcacaac tacatgagcc ccaccttctg tgaccactgc ggcagcctgc 1081 tctggggacc ggtgaagcag ggactaaagc gtgaagactg cggcatgaat gtgcaccata WO 00/09525 1310 PCT/US99/17712 1141 aatgccggga gaaggtggcc aacctctgcg gcatcaacca gaagcttttg gctgaggcct 1201 tgaaccaagt cacccagaga gcctcccgga gatcagactc agcctcctca gagcctgttg 1261 ggatatatca gggtttcgag aagaagaccg gagttgctgg ggaggacatg caagacaaca 1321 gtgggaccta cggcaagatc tgggagggca gcagcaagtg caacatcaac aacttcatct 1381 tccacaaggt cctgggcaaa ggcagcttcg ggaaggtgct gct (2) INFORMATION FOR SEQ ID NO:167: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 2244 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:167: 1 ctccccgccc cgaccatggt agtgttcaat ggccttctta agatcaaaat ctgcgaggcc 61 gtgagcttga agcccacagc ctggtcgctg cgccatgcgg tgggaccccg gccgcagact 121 ttccttctcg acccctacat tgccctcaat gtggacgact cgcgcatcgg ccaaacggcc 181 accaagcaga agaccaacag cccggcctgg cacgacgagt tcgtcaccga tgtgtgcaac 241 ggacgcaaga tcgagctggc tgtctttcac gatgccccca taggctacga cgacttcgtg 301 gccaactgca ccatccagtt tgaggagctg ctgcagaacg ggagccgcca cttcgaggac 361 tggattgatc tggagccaga aggaagagtg tatgtgatca tcgatctctc agggtcgtcg 421 ggtgaagccc ctaaagacaa tgaagagcgt gtgttcaggg aacgcatgcg gccgaggaag 481 cggcaggggg ccgtcaggcg cagggtccat caggtcaacg gccacaagtt catggccacc 541 tatcttcggc agcccaccta ctgctcccat tgcagagact tcatctgggg tgtcatagga 601 aagcagggat accagtgtca agtctgcacc tgcgtggtcc acaagcggtg ccacgagctc 661 ataatcacaa agtgtgctgg gttaaagaag caggagaccc ccgaccaggt gggctcccag 721 cggttcagcg tcaacatgcc ccacaagttc ggtatccaca actacaaggt ccctaccttc 781 tgcgatcact gtgggtccct gctctgggga ctcttgcggc agggtttgca gtgtaaagtc 841 tgcaaaatga atgttcaccg tcgatgtgag accaacgtgg ctcccaactg tggagtggat 901 gccagaggaa tcgccaaagt actggccgac ctgggcgtta ccccagacaa aatcaccaac 961 agcggccaga gaaggaaaaa gctcattgct ggtgccgagt ccccgcagcc tgcttctgga 1021 agctcaccat ctgaggaaga tcgatccaag tcagcaccca cctccccttg tgaccaggaa 1081 ataaaagaac ttgagaacaa cattcggaaa gccttgtcat ttgacaaccg aggagaggag 1141 caccgggcag catcgtctcc tgatggccag ctgatgagcc ccggtgagaa tggcgaagtc 1201 cggcaaggcc aggccaagcg cctgggcctg gatgagttca acttcatcaa ggtgttgggc 1261 aaaggcagct ttggcaaggt catgttggca gaactcaagg gcaaagatga agtatatgct 1321 gtgaaggtct taaagaagga cgtcatcctt caggatgatg acgtggactg cacaatgaca 1381 gagaagagga ttttggctct ggcacggaaa cacccgtacc ttacccaact ctactgctgc 1441 ttccagacca aggaccgcct ctttttcgtc atggaatatg taaatggtgg agacctcatg 1501 tttcagattc agcgctcccg aaaattcgac gagcctcgtt cacggttcta tgctgcagag 1561 gtcacatcgg ccctcatgtt coccatcag catggagtca tctacaggga tttgaaactg 1621 gacaacatcc ttctggatgc agaaggtcac tgcaagctgg ctgacttcgg gatgtgcaag 1681 gaagggattc tgaatggtgt gacgaccacc acgttctgtg ggactcctga ctacatagct 1741 cctgagatcc tgcaggagtt ggagtatggc ccctccgtgg actggtgggc cctgggggtg 1801 ctgatgtacg agatgatggc tggacagcct ccctttgagg ccgacaatga ggacgaccta 1861 tttgagtcca tcctccatga cgacgtgctg tacccagtct ggctcagcaa ggaggctgtc 1921 agcatcttga aagctttcat gacgaagaat ccccacaagc gcctgggctg tgtggcatcg 1981 cagaatggcg aggacgccat caagcagcac ccattcttca aagagattga ctgggtgctc 2041 ctggagcaga agaagatcaa gccacccttc aaaccacgca ttaaaaccaa aagagacgtc 2101 aataattttg accaagactt tacccgggaa gagccggtac tcacccttgt ggacgaagca 2161 attgtaaagc agatcaacca ggaggaattc aaaggtttct cctactttgg tgaagacctg 2221 atgccctgag agcccactgc agtt (2) INFORMATION FOR SEQ ID NO:168: Ci) SEQUENCE CHARACTERISTICS: (A) LENGTH: 218 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:168: agccggcttc tggaaactcc ctgtgtgagt gtgagggaat gagtatgaac aaggcacatt 61 atgtcttact tatgtatca gtcctgtt gctgctgtag caagttacca ccaatttatg 121 gcttaaagca attcaaattt tttccttga attcttaaga tcagaagttc aaatgagtc 181 taatggggct aaaatcaagg tgtaggcaa aggcagct (2) INFORMATION FOR SEQ ID NO:169: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1830 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:169: 1 tgcagctgga gatccgggct cccacagcag atgagatcca cgtaactgtt ggcgaggccc 61 gtaacctaat tcctaggac cccaatggtc tctctgatcc ctatgtgaaa ctgaagctca 121 tcccagaccc tcggaaccrg acgaaacaga agacccgaac ggtgaaaacc acgctaaacc WO 00/09525 1311 PCT/US99/17712 181 ctgtgtagaa tgagaccttt gtgttcaacc tgaagccagg ggatgtggag cgccggctca 241 gcgtggaggt gtgggactag gaccggacct cccgcaacga cttcatgggg gccatgcc 301 ttggcgtctc ggagctgctc aaggcgcccg tggatggctg gtacaagtta ctgaaccagg 361 aggagggcga gtattacaat gtgccggtgg ccgatgctga caactgcagc ctcctccaga 421 agtttgaggc ttgtaactac cccctggaat tgtatgagcg ggtgcggatg ggcccctctt 481 cctctcccat cccctcccct tcccctagrc ccaccgaccc caagcgctgc ttcttcgggg 541 cgagtccagg acgcctgcac acccgact tcagcttcct catggttcta ggaaaaggca 601 gttttgggaa ggtgatgctg gccgagcgca ggggctctga tgagctctac gccatcaaga 661 tcttgaaaaa ggacgtgatc qcccaggacg acgatgtgga ctgcacgctg gtggagaaac 721 gtgtgctggc gctggggggc cggggtcctg gcggccggcc ccacttcctc acccagctcc 781 actccacctt ccagaccccg gaccgcctgt atttcgtgat ggagtacgtc accgggggag 841 acttgatgta ccacattcaa cagctgggca agtttaagga gccccatgca gcgttctacg 901 cggcagaaat cgctatcggc ctcttcttcc ttcacaatca gggcatcatc tacagggacc 961 tgaagctgga caatgtgatg ctggatgctg agggacacat caagatcact gactttggca 1021 tgtgtaagga gaacgtcttc cccgggacga caacccgcac cttctgcggg accccggact 1081 acatagcccc ggagatcatt gcctaccagc cctatgggaa gtctgtcgat tggtggtcct 1141 ttggagttct gctgtatgag atgttggcag gacagcctcc cttcgatggg gaggacgagg 1201 aggagctgtt tcaggccatc atggaacaaa ctgtcaccca ccccaagtcg ctttcccggg 1261 aagccgtggc catctgcaag gggttcctga ccaagcaccc agggaagcgc ctgggctcag 1321 ggcctgatgg ggaacctacc atccgtgcac atggcttttt ccgctggatt gactgggagc 1381 ggctggaacg attggagatc ccgcctcctt tcagaccccg cccgtgtggc cgcagcggcg 1441 agaactttga caagttcttc acgcgggcgg cgccagcgct gacccctcca gaccgcctag 1501 tcctggccag catcgaccag gccgatttcc agggcttcac ctacgtgaac cccgacttcg 1561 tgcacccgga tgcccgcagc cccaccagcc cagtgcctgt gcccgtcatg taatctcacc 1621 cgccgccact aggtgtcccc aacgtcccct ccgccgtgcc ggcggcagcc ccacttcacc 1681 cccaacttca ccaccccctg tcccattcta gatcctgcac cccagcattc cagctctgcc 1741 cccgcgggtt ctagacgccc ctcccaagcg ttcctggcct tctgaactcc atacagcctc 1801 tacagccgtc ccgcgttcaa gacttgagcg (2) INFORMATION FOR SEQ ID NO:170: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 2196 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (0) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:170: cggggtgtct tgggcccggg cggctgtaga ggcggcggcg cctacgggca gtgggaggag 61 ccgcgcggtt ccggctgctc cggcgaggcg acccttgggt cggcgctgcg ggcaggtggc 121 aggtaggtgg cggacggccg cggttctccg gcaagcgcag gcggcggagt cccccacggc 181 gcccgaagcg cccccccgca cccccggcct ccagcgttga ggcgggggag tgaggagatg 241 ccgacccaga gggacagcag caccatgtcc cacacggtcg caggcggcgg cagcggggac 301 cattcccacc aggtccgggt gaaagcctac taccgcgggg atatcatgat aacacattt 361 gaaccttcca tccctcga gggcctttgc aatgaggttc gagacatgt ttcttttgac 421 aacgaacagc tcttcaccat gaaatggata gatgaggaag gagacccgtg tacagtatca 481 tctcagttgg agttagaaga agccttta a ctttatgagc taaacaagga ttctgaactc 541 ttgagtcatg tgatcccttg tgtaccagaa cgtcctggga tgccttgtcc aggagaagat 601 aaatccatct accgtagagg tgcacgccgc tggagaaagc tttattgtgc caatggccac 661 actttccaag ccaagcgttt caacaggcgt gctcactgtg ccatctgcac agaccgaata 721 tggggacttg gacgccaagg atataagtgc atcaactgca aactcttggt tcataagaag 781 tgccataaac tcgtcacaat tgaatgtggg cggcattctt tgccacagga accagtgatg 841 cccatggatc agtcatccatc gcattctgac catgcacaga cagtaattcc atataatcct 901 tcaagtcatg agagtttgga tcaagttggt gaagaaaaag aggcaatgaa caccagggaa 961 agtggcaaag cttcatccag tctaggtctt caggattttg atttgctccg ggtaatagga 1021 agaggaagtt atgccaaagt actgttggtt cgattaaaaa aaacagatcg tatttatgca 1081 atgaaagttg tgaaaaaaga gcttgttaat gatgatgagg atatgattg ggtacagaca 1141 gagaagcatg tgtttgagca ggcatccaat catcctttcc ttgttgggct gcattcttgc 1201 tttcagacag aaagcagat gttctttgtt atagagtatg taaatggagg agacctaatg 1261 tttcatatgc agcgacaaag aaaacttcct gaagaacatg ccagatttta ctctgcagaa 1321 atcagtctag cattaaatta tcttcatgag cgagggataa tttatagaga tttgaaactg 1381 gacaatgtat tactggactc tgaaggccac attaaactca ctgactacgg catgtgtaag 1441 gaaggattac ggccaggaga tacaaccagc actttctgtg gtactcctaa ttacattgct 1501 cctgaaattt taacaggaga agattatggt ttcagtgttg actggtgggc tcttggagtg 1561 ctcatgtttg agatgatggc aggaaggcct ccatttgata ttgttgggag ctccgataac 1621 cctgaccaga acacagagga ttatctcttc caagttattt tggaaaaaca aattcgcata 1681 ccacgttctc tgtctgtaaa agctgcaagc gttctgaaga gttttcttaa taaggaccct 1741 aaggaacgat tgggttgtca tcctcaaaca ggatttgctg atattcaggg acacccgctc 1801 ttccgaaatg ttgattggga tatgatggag caaaaacagg tggtacctcc ctttaaacca 1861 aacatttctg gggaatttgg tttggacaac tttgattctc agtttactaa tgaacctgtc 1921 cagctcactc cagatgacga tgacattgtg aggaagattg atcagtctga atttgaaggt 1981 tttgagtata tcaacccc ttcgatgtct gcagaagaat gtgtctgatc ccatttttc 2041 aaccatgtat tctactcata ttgccattta atgcatggat aaacttgctg caagcctgga 2101 tacaattaac cattttacat ttgccaccga caaaaaaaca cccaatact tctcttgtag WO 00/09525 1312 PCT/US99/17712 2161 actatatgaa tcaattatta catctcgacc cggaat (2) INFORMATION FOR SEQ ID NO:171: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 2389 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:171: 1 gaattcggac ggaggaggca gaatggccag tcgaggggcg cttaggcgtg gcctttcccc 61 agggctgcct cgactcctgc acctgtcccg agggctggcc tgagacggga ctcccggttc 121 tcccgctgcg aagcaggccc cccggggccg gggcagcggc gccggcatgt cgtctggcac 181 catgaagttc aatggctatt tgagggtccg catcggtgag gcagtggggc tgcagcccac 241 ccgctggtcc ctgcgccact cgctcttcaa gaagggccac cagctgctgg acccctatct 301 gacggtgagc gtggaccagg tgcgcgtggg ccagaccagc accaagcaga agaccaacaa 361 acccacgtac aacgaggagt tttgcgctaa cgtcaccgac ggcggccacc tcgagttggc 421 cgtcttccac gagacccccc tgggctacga cttcgtggcc aactgcaccc tgcagttcca 481 ggagctcgtc ggcacgaccg gcgcctcgga caccttcgag ggttgggtgg atctcgagcc 541 agaggggaaa gtatttgtgg taataaccct taccgggagt ttcactgaag ctactctcca 601 gagagaccgg atcttcaaac attttaccag gaagcgccaa agggctatgc gaaggcgagt 661 ccaccagatc aatggacaca agttcatggc cacgtatctg aggcagccca cctactgctc 721 tcactgcagg gagtttatct ggggagtgtt tgggaaacag ggttatcagt gccaagtgtg 781 cacctgtgtc gtccataaac gctgccatca tctaattgtt acagcctgta cttgccaaaa 841 caatattaac aaagtggatt caaagattgc agaacagagg ttcgggatca acatcccaca 901 caagttcagc atccacaact acaaagtgcc aacattctgc gatcactgtg gctcactgct 961 ctggggaata atgcgacaag gacttcagtg taaaatatgt aaaatgaag tgcatattcg 1021 atgtcaagcg aacgtggccc ctaactgtgg ggtaaatgcg gtggaacttg ccaagaccct 1081 ggcagggatg ggtctccaac ccggaaatat ttctccaacc tcgaaactcg tttccagatc 1141 gaccctaaga cgacagggaa aggagagcag caaagaagga aatgggattg gggttaattc 1201 ttccaaccga cttggtatcg acaactttga gttcatccga gtattgggga aggggagttt 1261 tgggaaggtg atgcttgcaa gagtaaaaga aacaggagac ctctatgctg tgaaggtgct 1321 gaagaaggac gtgattctgc tggatgatga tgtggaatgc accatgaccg agaaaaggat 1381 cctgtctctg gcccgcaatc accccttcct cactcagttg ttctgctgct ttcagacccc 1441 cgatcgtctg ttttttgtga tggagtttgt gaatgggggt gacttgatgt tccacattca 1501 gaagtctcgt cgttttgatg aagcacgagc tcgcttctat gctgcagaaa tcatttcggc 1561 tctcatgttc ctccatgata aaggaatcat ctatagagat ctgaaactgg acaatgtcct 1621 gttggaccac gagggtcact gtaaactggc agacttcgga atgtgcaagg aggggatttg 1681 caatggtgtc accacggcca cattctgtgg cacgccagac tatatcgctc cagagatcct 1741 ccaggaaatg ctgtacgggc ctgcagtaga ctggtgggca atgggcgtgt tgctctatga 1801 gatgctctgt ggtcacgcgc cttttgaggc agagaatgaa gatgacctct ttgaggccat 1861 actgaatgat gaggtggtct accctacctg gctccatgaa gatgccacag ggatcctaaa 1921 atctttcatg accaagaacc ccaccatgcg cttgggcagc ctgactcagg gaggcgagca 1981 cgccatcttg agacatcctt tttttaagga aatcgactgg gcccagctga accatcgcca 2041 aatagaaccg cctttcagac ccagaatcaa atcccgagaa gatgtcagta attttgaccc 2101 tgacttcata aaggaagagc cagttttaac tccaattgat gagggacatc ttccaatgat 2161 taaccaggat gagtttagaa acttttccta tgtgtctcca gaattgcaac catagcctta 2221 tggggagtga gagagagggc acgagaaccc aaaggaatag agattctcca ggaatttcct 2281 ctatcggacc ttcccagcat cagccttaga acaagaacct taccttcaag gagcaagtga 2341 agaactctgt cgaaggatgg aactttcaga tatcaactat ttagagtcc (2) INFORMATION FOR SEQ ID NO:172: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 3742 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear )xi(SEQUENCE DESCRIPTION: SEQ ID NO:172: 1 gaattccttc tcacctcctc ctcgcccttc cctcgccct cctcctcctc ctcgccctcc 61 cctcccgatc ctcatcccct tgccctcccc cagcccaggg acttttccgg aaagttttta 121 ttttccgtct gggctctcgg agaaagaagc tcctggctca gcggctgcaa aactttcctg 181 ctgccgcgcc gccagccccc gccctccgca gcccggccct gcgccccgcc gagcgatgag 241 cgcccctccg gtcctgcggc cgcccagtcc gctgctgccc gtggcggcgg cagctgccgc 301 agcggccgcc gcactggtcc cagggtccgg gcccgggccc gcgccgttct ggctcctgt 361 cgcggccccg gtcgggggca tctcgttcca tctgcagatc ggcctgagcc gtgagccggt 421 gctgctgctg caggactcgc ccggggacta cagcctggcg cacgtccgcg agatggcttg 481 ctccattgtc gaccagaagt tccctgaatg tggtttctac ggaatgtatg ataagacct 541 gctttttcgc catgacccta cctctgaaaa catccttcag ctggtgaaag cggccagtga 601 tatccaggaa ggcgatctta ttgaagtggt cttgtcacgt tccgccacct ttgaagactt 661 tcagattcgt ccccacgctc tctttgttca ttcatacaga gctccagctt tctgtgatca 721 ctgtggagaa atgccgtggg ggctggtacg tcaaggtctt aaatgtgaag ggtgtggtct 781 gaattaccat aagagatgtg catttaaaat acccaacaat tgcagcggtg tgaggcggag 841 aaggctctca aacgtttccc tcactggggt cagcaccatc cgcacatcat ctgctgaact 901 ctctacaagt gcccctgatg agccccttct gcaaaaatca ccatcagagt cgtttattgg 961 tcgagagaag aggtcaaatt ccaatcaa cattggacga ccaattcacc ttgacaagat 1021 tgatgtc aaagttcaaag tgccgcacac atttgtcatc cactcctaca cccggcccac WO 00/09525 1313 PCT/US99/17712 1081 agtgtgccag tactgcaaga agcttctgaa ggggcttttc aggcagggct tgcagtgcaa 1141 agattgcaga ttcaactgcc ataaacgttg tgcaccgaaa gtaccaaaca actgccttgg 1201 cgaagtgacc attaatggag atcgcttag ccctggggca gagtctgatg tggtcatgga 1261 agaagggagt gatgacaatg atagtgaaag gaacagtggg ctcatggatg atatggaaga 1321 agcaatggtc caagatgcag agatggcaat ggcagagtgc cagaacgaca gtggcgagat 1381 gcaagatcca gacccagacc acgaggacgc caacagaacc atcagtccat caacaagcaa 1441 caatatccca ctcatgaggg tagtgcagtc tgtcaaacac acgaagagga aaagcagcac 1501 agtcatgaaa gaaggatgga tggtccacta caccagcaag gacacgctgc ggaaacggca 1561 ctattggaga ttggatagca aatgtattac cctctttcag aatgacacag gaagcaggta 1621 ctacaaggaa attcctttat ctgaaatttt gtctctggaa ccagtaaaaa cttcagcttt 1681 aattcctaat ggggccaatc ctcattgttt cgaaatcact acggcaaatg tagtgtatta 1741 tgtgggagaa aatgtggtca atccttccag cccatcacca aataacagtg ttctcaccag 1801 tggcgttggt gcagatgtgg ccaggatgtg ggagatagcc atccagcatg cccttatgcc 1861 cgtcattccc aagggctcct ccgtgggtac aggaaccaac ttgcacagag ataccctgt 1921 gagtatttca gtatcaaatt gccagattca agaaaatgtg gacatcagca cagtatatca 1981 gattttcct gatgaagtac tgggttctgg acagtttgga attgtttatg gaggaaaaca 2041 tcgtaaaaca ggaagagatg tagctattaa aatcattgac aaattacgat ttccaacaaa 2101 acaagaaagc cagcttcgta atgaggttgc aattctacag aaccttcatc accctggtgt 2161 tgtaaatttg gagtgtatgt ttgagacgcc tgaaagagtg tttgttgtta tggaaaaact 2221 ccatggagac atgctggaaa tgatcttgtc aagtgaaaag ggcaggttgc cagagcacat 2281 aacgaagttt ttaattactc agatactcgt ggctttgcgg caccttcatt ttaaaaatat 2341 cgttcactgt gacctcaaac cagaaaatgt gttgctagcc tcagctgatc Cttttcctca 2401 ggtgaaactt tgtgattttg gttttgcccg gatcattgga gagaagtctt tccggaggtc 2461 agtggtgggt acccccgctt acctggctcc tgaggtccta aggaacaagg gctacaatcg 2521 ctctctagac atgtggtctg ttggggtcat catctatgta agcctaagcg gcacattccc 2581 atttaatgaa gatgaagaca tacacgacca aattcagaat gcagctttca tgtatccacc 2641 aaatccctgg aaggaaatat ctcatgaagc cattgatctt atcaacaatt tgctgcaagt 2701 aaaaatgaga aagcgctaca gtgtggataa gaccttgagc cacccttggc tacaggacta 2761 tcagacctgg ttagatttgc gaaagctgga atgcaaaatc ggggagcgct acatcaccca 2821 tgaaagtgat gacctgaggt gggagaagta tgcaggcgag cagcggctgc agtaccccac 2881 acacctgatc aatccaagtg ctagccacag tgacactcct gagactgaag aaacagaaat 2941 gaaagccctc ggtgagcgtg tcagcatcct ctgagttcca tctcctataa tctgtcaaaa 3001 cactgtggaa ctaataaata catacggtca ggtttaacat ttgccttgca gaactgccat 3061 tattttctgt cagatgagaa caaagctgtt aaactgttag cactgttgat gtatctgagt 3121 tgccaagaca aatcaacaga agcatttgta ttttgtgtga ccaactgtgt tgtattaaca 3181 aaagttccct gaaacacgaa acttgttatt gtgaatgatt catgttatat ttaatgcatt 3241 aaacctgtct ccactgtgcc tttgcaaatc agtgtttttc ttactggagc ttcattttgg 3301 taagagacag aatgtatctg tgaagtagtt ctgtttggtg tgtcccattg gtgttgtcat 3361 tgtaaacaaa ctcttgaaga gtcgattatt tccagtgttc tatgaacaac tccaaaaccc 3421 atgtgggaaa aaaatgaatg aggagggtag ggaataaaat cctaagacac aaatgcatga 3481 acaagtttta atgtatagtt ttgaatcctt tgcctgcctg gtgtgcctca gtatatttaa 3541 actcaagaca atgcacctag ctgtgcaaga cctagtgctc ttaagcctaa atgccttaga 3601 aatgtaaact gccatatata acagatacat ttccctcttt cttataatac tctgttgtac 3661 tatggaaaat cagctgctca gcaacctttc acctttgtgt atttttcaat aataaaaaat 3721 attcttgtca aaaaaaaaaa aa (2) INFORMATION FOR SEQ ID NO:173: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 2705 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi) SEQUENCE DESCRIPTION: SEQ ID NO:173: 1 tgctcgctcc agggcgcaac catgtcgcca tttcttcgga ttggcttgtc caactttgac 61 tgcgggtcct gccagtcttg tcagggcgag gctgttaacc cttactgtgc tgtgctcgtc 121 aaagagtatg tcgaatcaga gaacgggcag atgtatatcc agaaaaagcc taccatgtac 181 ccaccctggg acagcacttt tgatgccca atcaacaagg gaagagtcat gcagatcatt 241 gtgaaaggca aaaacgtgga cctcatctct gaaaccaccg tggagctcta ctcgctggct 301 gagaggtgca ggaagaacaa cgggaagaca gaaatatggt tagagctgaa acctcaaggc 361 cgaatgctaa tgaatgcaag atactttctg gaaatgagtg acacaaagga catgaatgaa 421 cttgagacgg aaggcttctt tgctttgcat cagcgccggg gtgcatcaa gcaggcaaag 481 gtccaccacg tcaagtgcca cgagttcact gccaccttct tcccacagcc cacattttgc 541 tctgtctgcc acgagtttgt ctggggcctg aacaaacagg gctaccagtg ccgacaatgc 601 aatgcagcaa ttcacaagaa gtgtattgat aaagttatag caaagtgcac aggatcagct 661 acaatagcc gagaaaccac gttccacaag gagagattca aaattgacat gccacacaga 721 tctaaaqtct acaattacaa gagcccgacc ttctgtgaac actgtgggac cctgctgtgg 781 ggactggcac ggcaaggact caagtgtgat gcatgtggca tgaatgtgca tcatagatgc 841 cagacaaagg tggccaacca ttgtggcata aaccagaagc taatggctga agcgctggcc 901 acgattgaga gcactcaaca ggctcgctgc ttaagagata ctgaacagat cttcagagaa 961 ggtccggttg aaattggtct cccatgctcc atcaaaaatg aagcaaggcc gccatgttta 1021 ccgacaccgg gaaaaagaga cctcagggc atttcctggg agtctccgtt ggatgaggtg 1081 gataaaatg gccatcttcc agaacctgaa ctgaacaaag aaagaccatc ccgcagatt 1141 aaactaaaaa atgaggacct tatcttgcac aaaatgttgg ggaaaggaag ttttggcaag 1201 g acttcctgg cagaattcaa gaaaaccaa caatttttcg caataaaggc cttaaagaaa 1261 gagtggccct tgatggacga tatgttgag tgcacgatgg tagagaagag agttctttcc WO 00/09525 1314 PCT/US99/17712 1321 ttggcctggg agcatccgtt tctgacgcac atgttttgta cattccagac caaggaaaac 1381 ctcttttttg tgatggagta cctcaacgga ggggacttaa tgtaccacat ccaaagctgc 1441 cacaagttcg acctttccag agcgacgttt tatgctgctg aaatcattct tggtctgcag 1501 ttccttcatt ccaaaggaat agtctacagg gacctgaagc tagataacat cctgttagac 1561 aaagatggac atatcaagat cgcggatttt ggaatgtgca aggagaacat gttaggagat 1621 gccaagacga ataccttctg tgggacacct gactacatcg ccccagagat cttgctgggt 1681 cagaaataca accactctgt ggactggtgg tccttcgggg ttctccttta tgaaatgctg 1741 attggtcagt cgcctttcca cgggcaggat gaggaggagc tcttccactc catccgcatg 1801 gacaatccct cttacccacg gtggctggag aaggaagcaa aggaccttct ggtgaagctc 1861 ttcgtgcgag aacctgagaa gaggctgggc gtgaggggag acatccgcca gcaccctttg 1921 tttcgggaga tcaactggga ggaacttgaa cggaaggaga ttgacccacc gttccggccg 1981 aaagtgaaat caccatttga ctgcagcaat ttcgacaaag aattcttaaa cgagaagccc 2041 cggctgtcat ttgccgacag agcactqatc aacagcatgg accagaatat gttcaggaac 2101 ttttccttca tgaaccccgg gatggagcgg ctgatatcct gaatcttgcc cctccagaga 2161 caggaaagaa tttgccttct ccctgggaac tggttcaaga gacactgctt gggttccttt 2221 ttcaacttgg aaaaagaaag aaacactcaa caataaagac tgagacccgt tcgcccccat 2281 gtgactttat ctgtagcaga aaccaagtct acttcactaa tgacgatgcc gtgtgtctcg 2341 tctcctgaca tgtctcacag acgctcctga agttaggtca ttactaacca tagttattta 2401 cttgaaagat gggtctccgc acttggaaag gtttcaagac ttgatactgc aataaattat 2461 ggctcttcac ctgggcgcca actgctgatc aacgaaatgc ttgttgaatc aggggcaaac 2521 ggagtacaga cgtctcaaga ctgaaacggc cccattgcct ggtctagtag cggatctcac 2581 tcagccgcag acaagtaatc actaacccgt tttattctat cctatctgtg gatgtataaa 2641 tgctgggggc cagccctgga taggttttta tgggaattct ttacaataaa catagcttgt 2701 acttg (2) INFORMATION FOR SEQ ID NO:174: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1779 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:174: 1 atgcccagca ggaccgaccc caagatggaa gggagcggcg gccgcgtccg cctcaaggcg 61 cattacgggg gggacatctt catcaccagc gtggacgccg ccacgacctt cgaggagctc 121 tggaggaag tgagagacat gtgtcgtctg caccagcagc acccgctcac cctcaagtgg 181 gtggacagcg aaggtgaccc ttgcacggtg tcctcccaga tggagctgga agaggctttc 241 cgcctggccc gtcagtgcag ggatgaaggc ctcatcattc atgttttccc gagcacccct 301 gagcagcctg gcctgccatg tccgggagaa gacaaatcta tctaccgccg gggagccaga 361 agatggagga agctgtaccg tgccaacggc cacctcttcc aagccaagcg ctttaacagg 421 agagcgtact gcggtcagtg cagcgagagg atatggggcc tcgcgaggca aggctacagg 481 tgcatcaact gcaaactgct ggtccataag cgctgccacg gcctcgtccc gctgacctgc 541 aggaagcata tggattctgt catgccttcc caagagcctc cagtagacga caagaacgag 601 gacgccgacc ttccttccga ggagacagat ggaattgctt acatttcctc atcccggaag 661 catgacagca ttaaagacga ctcggaggac cttaagccag ttatcgatgg gatggatgga 721 atcaaaatct ctcaggggct tgggctgcag gactttgacc taatcagagt catcgggcgc 781 gggacgtacg ccaaggttct cctggtgcgg ttgaagaaga atgaccaaat ttacgccatg 841 aaagtggtga agaaagagct ggtgcatgat gacgaggata ttgactgggt acagacagag 901 aagcacgtgt ttgagcaggc atccagcaac cccttcctgg tcggattaca ctcctgcttc 961 cagacgacaa gtcggttgtt cctggtcatt gagtacgtca acggcgggga cctgatgttc 1021 cacatgcaga ggcagaggaa gctccctgag gagcacgcca ggttctacgc ggccgagatc 1081 tgcatcgccc tcaacttcct gcacgagagg gggatcatct acagggacct gaagctggac 1141 aacgtcctcc tggatgcgga cggacacatc aagctcacag actacggcat gtgcaaggaa 1201 ggcctgggcc ctggtgacac aacgagcact ttctgcggaa ccccgaatta catcgccccc 1261 gaaatcctgc ggggagagga gtacgggttc agcgtggact ggtgggcgct gggagtcctc 1321 atgtttgaga tgatggccgg gcgctccccg ttcgacatca tcaccgacaa cccggacatg 1381 aacacagagg actacctttt ccaagtgatc ctggagaagc ccatccggat cccccggttc 1441 ctgtccgtca aagcctccca tgttttaaaa ggatttttaa ataaggaccc caaagagagg 1501 ctcggctgcc ggccacagac tggattttct gacatcaagt cccacgcgtt cttccgcagc 1561 atagactggg acttgctgga gaagaagcag tcgctccctc cattccagcc acagatcaca 1621 gacgactacg gtctggacaa ctttgacaca cagttcacca gcgagcccgt gcagctgacc 1681 ccagacgatg aggatgccat aaagaggatc gaccagtcag agttcgaagg ctttgagtat 1741 atcaacccat tattgctgtc caccgaggag tcggtgtga (2) INFORMATION FOR SEQ ID NO:175: )i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 239 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear )xi)SEQUENCE DESCRIPTION: SEQ ID NO:175: 1 tgtcatgcct tcccaagagc ctccaggatg gctgtcctcc gacctcctcc acctccaggc 61 tctagatggc aaagcccact aagcaaaagc cacctgctct gtgatgatgg gactggctcc 121 tacctgtggg ttcggaaagc ccatcccacc ctctacagcc tcttgctcct cgcaatgac WO 00/09525 1315 PCT/US99/17712 181 tgtgccttca cctgggggtt ccccagagac tagtgagagt catcgggcgt ggaagctat (2) INFORMATION FOR SEQ ID NO:176: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 38634 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:176: 1 ggagcaagag gtggttgggg ggggaccatg gctgacgttt tcccgggcaa cgactccacg 61 gcgtctcagg acgtggccaa ccgcttcgcc cgcaaagggg cgctgaggca gaagaacgtg 121 cacgaggtga aggaccacaa attcatcgcg cgcttcttca agcagcccac cttctgcagc 181 cactgcaccg acttcatctg ggggtttggg aaacaaggct tccagtgcca agtttgctgt 241 tttgtggtcc acaagaggtg ccatgaattt gttacttttt cttgtccggg tgcggataag 301 ggacccgaca ctgatgaccc caggagcaag cacaagttca aaatccacac ttacggaagc 361 cccaccttct gcgatcactg tgggtcactg ctctatggac ttatccatca agggatgaaa 421 tgtgacacct gcgatatgaa cgttcacaag caatgcgtca tcaatgtccc cagcctctgc 481 ggaatggatc acactgagaa gagggggcgg atttacctaa aggctgaggt tgctgatgaa 541 aagctccatg tcacagtacg agatgcaaaa aatctaatcc ctatggatcc aaacgggctt 601 tcagatcctt atgtgaagct gaaacttatt cctgatccca agaatgaaag caagcaaaaa 661 accaaaacca tccgctccac actaaatccg cagtggaatg agtcctttac attcaaattg 721 aaaccttcag acaaagaccg acgactgtct gtagaaatct gggactggga tcgaacaaca 781 aggaatgact tcatgggatc cctttccttt ggagtttcgg agctgatgaa gatgccggcc 841 agtggatggt acaagttgct taaccaagaa gaaggtgagt actacaacgt acccattccg 901 gaaggggacg aggaaggaaa catggaactc aggcagaaat tcgagaaagc caaacttggc 961 cctgctggca acaaagtcat cagtccctct gaagacagga aacaaccttc caacaacctt 1021 gaccgagtga aactcacgga cttcaatttc ctcatggtgt tgggaaaggg gagttttgga 1081 aaggtgatgc ttgccgacag gaagggcaca gaagaactgt atgcaatcaa aatcctgaag 1141 aaggatgtgg tgattcagga tgatgacgtg gagtgcacca tggtagaaaa gcgagtcttg 1201 gccctgcttg acaaaccccc gttcttgacg cagctgcact cctgcttcca gacagtggat 1261 cggctgtact tcgtcatgga atatgtcaac ggtggggacc tcatgtacca cattcagcaa 1321 gtaggaaaat ttaaggaacc acaagcagta ttctatgcgg cagagatttc catcggattg 1381 ttctttcttc ataaaagagg aatcatttat agggatctga agttagataa cgtcatgttg 1441 gattcagaag gacatatcaa aattgctgac tttgggatgt gcaaggaaca catgatggat 1501 ggagtcacga ccaggacctt ctgtgggact ccagattata tcgccccaga gataatcgct 1561 tatcagccgt atggaaaatc tgtggactgg tgggcctatg gcgtcctgtt gtatgaaatg 1621 cttgccgggc agcctccatt tgatggtgaa gatgaagacg agctatttca gtctatcatg 1681 gagcacaacg tttcctatcc aaaatccttg tccaaggagg ctgtttctat ctgcaaagga 1741 ctgatgacca aacacccagc caagcggctg ggctgtgggc ctgaggggga gagggacgtg 1801 agagagcatg ccttcttccg gagqatcgac tgggaaaaac tggagaacag ggagatccag 1861 ccaccattca agcccaaagt gtgtggcaaa ggagcagaga actttgacaa gttcttcaca 1921 cgaggacagc ccgtcttaac accacctgat cagctggtta ttgctaacat agaccagtct 1981 gattttgaag ggttctcgta tgtcaacccc cagtttgtgc accccatctt acagagtgca 2041 gtatgaaact caccagcgag aacaaacacc tccccagccc ccagccctcc ccgcagtgga 2101 agtgaatcct taaccctaaa atttaaggc cacggcttgt gtctgattcc atatggaggc 2161 ctgaaaattg tagggttatt agtccaaatg tgatcaactg ttcagggtct ctctcttaca 2221 accaagaaca ttatcttagt ggaag 1 cttatcacag ttcaagtgat ttccagaagt tccaggctt ctgagagacc atcaagggaa 61 ctttaacaac ttgacaaatg tccttgaagt aagatgcctc atctttaggg aaaaatgggg 121 tttggatttc tgcttaggca aagtctcctg cagttcatcc ttctctgtcc tcttcttgct 181 tcaggcttgg ggaccgtccc tgctgtcccc actgtggtgg caatcaggac ctaaggtgaa 241 gcaaacttga agttctatct gacaagttta ggcagtaaga gaaggaggga aatcggagca 301 aagctccctc actttattgt tgagaaactg gcatctggaa agaagaagga atttgcccaa 361 agtcagtcag ctgggataaa aacctgggtg tcctgtccag aaagtgcagg gtgctttctg 421 ctctgtagca aggcagcaga catctctgag ccaggcccac caacaggccc ttatctggtg 481 gttggatcat gatcccattt tacttggaca tgctctcagg aagataaaaa ccatggagaa 541 acactaggcc attgacaaat gatctgagac aactttagaa aacaatgtag gatgaatgga 601 aagagaaaga aagaaagaa aaaaaaaaaa aaaagg cagagccggc gcaggggaag cgcccggggc cccgggtgca gcagcgcccg ccgcctcccg 61 ggcctccccg gcccgcagcc cggggtcccg ggccccgggg ccggcacctc tcgggctccg 121 gctccccgcg cgcaagatgg ctgacccggc tgcggggccg ccgccgagcg agggcgagga 181 gagcaccgtg cgcttcgccc gcaaaggcgc ccccggcag aagaacgtgc atgaggtcaa 241 gaaccacaaa ttcaccgccc gcttctcaa gcagcccacc ttctgcagcc actgcaccga 301 cttcatctgg ggcttcggga agcagggatt ccagtgccaa gtttgctgct ttgtggtgca 361 caagcggtgc catgaatttg tcacattctc ctgccctggc gctgacaagg gtccagcctc 421 cgatgacccc cgcagcaaac acaagtttaa gatccacacg tactccagcc ccacgttttg 481 tgaccactgt gggtcactgc tgtatggact catccaccag gggatgaaat gtgacacctg 541 catgatgaat gtgcacaagc actgcgtgat gaatgttccc agcctgtgtg gcacggacca 601 cacggagcgc cgcggccgca tctacatcca ggcccacatc gacagggacg tcctcattgt WO 00/09525 1316 PCT/US99/17712 661 cctcgtaaga gatgCtaaaa accttgtacc tatggacccc aatggcctgt cagatcccta 721 cgtaaaactg aaactgattc ccgatcccaa aagtgagagc aaacagaaga ccaaaaccat 781 caaatgctcc ctcaaccctg agtggaatga gacatttaga tttcagctga aagaatcgga 841 caaagacaga agactgtcag tagagatttg ggattgggat ttgaccagca ggaatgactt 901 catgggatct ttgtcctttg ggatttctga acttcagaag gccagtgttg atggctggtt 961 taagttactg agccaggagg aaggcgagta cttcaatgtg cctgtgccac cagaaggaag 1021 tgaggccaat gaagaactgc ggcagaaatt tgagagggcc aagatcagtc agggaaccaa 1081 ggtcccggaa gaaaagacga ccaacactgt ctccaaattt gacaacaatg gcaacagaga 1141 ccggatgaaa ctgaccgatt ttaacttcct aatggtgctg gggaaaggca gctttggcaa 1201 ggtcatgctt tcagaacgaa aaggcacaga tgagctctat gctgtgaaga tcctgaagaa 1261 ggacgttgtg atccaagatg atgacgtgga gtgcactatg gtggagaagc gggtgttggc 1321 cctgcctggg aagccgccct tcctqaccca gctccactcc tgcttccaga ccatggaccg 1381 cctgtacttt gtgatggagt acgtgaatgg gggcgacctc atgtatcaca tccagcaagt 1441 cggccggttc aaggagcccc atgctgtatt ttacgctgca gaaattgcca tcggtctgtt 1501 cttcttacag agtaagggca tcatttaccg tgacctaaaa cttgacaacg tgatgctcga 1561 ttctgaggga cacatcaaga ttgccgattt tggcatgtgt aaggaaaaca tctgggatgg 1621 ggtgacaacc aagacattct gtggcactcc agactacatc gcccccgaga taattgctta 1681 tcagccctat gggaagtccg tggattggtg ggcatttgga gtcctgctgt atgaaatgtt 1741 ggctgggcag gcaccctttg aaggggagga tgaagatgaa ctcttccaat ccatcatgga 1801 acacaacgta gcctatccca agtctatgtc caaggaagct gtggccatct gcaaagggct 1861 gatgaccaaa cacccaggca aacgtctggg ttgtggacct gaaggcgaac gtgatatcaa 1921 agagcatgca tttttccggt atattgattg ggagaaactt gaacgcaaag agatccagcc 1981 cccttataag ccaaaagcta gagacaagag agacacctcc aacttcgaca aagagttcac 2041 cagacagoct gtggaactga cccccactga taaactcttc atcatgaact tggaccaaaa 2101 tgaatttgct ggcttctctt atactaaccc agagtttatc attaatgtgt aggtgaatgc 2161 aaactccatc gttgagcctg gggtgtaaga cttcaagcca agcgtatgta tcaattctag 2221 tcttccagga ttcacggtgc acatgctggc attcaacatg tggaaagctt gtcttagagg 2281 cctttcttgt atgtgtagct tgctagtttg ttttctacat ttgaaaatgt ttagtttaga 2341 ataagcgcat tatccaatta tagaggtaca attttccaaa cttccagaaa ctcatcaaat 2401 gaacagacaa tgtcaaaact actgtgtctg ataccaaaat gcttcagtat ttgtaatttt 2461 tcaagtcaga agctgatgtt cctggtaaaa gtttttacag ttattctata atatcttctt 2521 tgaatgctaa gcatgagcga tatttttaaa aattgtgagt aagcttcgga attc 1cagagccggc gcaggggaag cgcccggggc cccgggtgca gcagcgcccg ccgcctcccg 61 ggcctccccg gcccgcagcc cggggtcccg ggccccgggg ccggcacctc tcgggctccg 121 gctccccgcg cgcaagatgg ctgacccggc tgcggggccg ccgccgagcg agggcgagga 181 gagcaccgtg cgcttcgccc gcaaaggcgc cctccggcag aagaacgtgc atgaggtcaa 241 gaaccacaaa ttcaccgccc gcttcttcaa gcagcccacc ttctgcagcc actgcaccga 301 cttcatctgg ggcttcggga agcagggatt ccagtgccaa gtttgctgct ttgtggtgca 361 caagcggtgc catgaatttg tcacattctc ctgccctggc gctgacaagg gtccagcctc 421 cgatgacccc cgcagcaaac acaagtttaa gatccacacg tactccagcc ccacgttttg 481 tgaccactgt gggtcactgc tgtatggact catccaccag gggatgaaat gtgacacctg 541 catgatgaar gtgcacaagc gctgcgtgat gaatgttccc agcctgtgtg gcacggacca 601 cacggagcgc cgcggccgca tctacatcca ggcccacatc gacagggacg tcctcattgt 661 cctcgtaaga gatccaaaa accttgtacc tatggacccc aatggcctgt cagatcccta 721 cgtaaaactg aaactgattc ccgatcccaa aagtgagagc aaacagaaga ccaaaaccat 781 caaatgctcc ctcaaccctg agtggaatga gacatttaga tttcagctga aagaatcgga 841 caaagacaga agactgtcag tagagatttg ggattgggat ttgaccagca ggaatgactt 901 catgggatct ttgtcctttg ggatttctga acttcagaag gccagtgttg atggctggtt 961 taagttactg agccaggagg aaggcgagta cttcaatgtg cctgtgccac cagaaggaag 1021 tgaggccaat gaagaactgc ggcagaaatt tgagagggcc aagatcagtc agggaaccaa 1081 ggtcccggaa gaaaagacga ccaacactgt ctccaaattt gacaacaatg gcaacagaga 1141 ccggatgaaa ctgaccgatt ttaacttcct aatggtgctg gggaaaggca gctttggcaa 1201 ggtcatgctt tcagaacgaa aaggcacaga tgagctctat gctgtgaaga tcctgaagaa 1261 ggacgttgtg atccaagatg atgacgtgga gtgcactatg gtggagaagc gggtgttggc 1321 cctgcctggg aagccgccct tcctgaccca gctccactcc tgcttccaga ccatggaccg 1381 cctgtacttt gtgatggagt acgtgaatgg gggcgacctc atgtatcaca tccagcaagt 1441 cggccggttc aaggagcccc atgctgtatt ttacgctgca gaaattgcca tcggtctgtt 1501 cttcttacag agtaagggca tcatttaccg tgacctaaaa cttgacaacg tgatgctcga 1561 ttctgaggga cacatcaaga ttgccgattt tggcatgtgt aaggaaaaca tctgggatgg 1621 ggtgacaacc aagacattct gtggcactcc agactacatc gcccccgaga taattgctta 1681 tcagccctat gggaagtccg tggattggtg ggcatttgga gtcctgctgt atgaaatgtt 1741 ggctgggcag gcaccctttg aaggggagga tgaagatgaa ctcttccaat ccatcatgga 1801 acacaacgta gcctatccca agtctatgtc caaggaagct gtggccatct gcaaagggct 1861 gatgaccaaa cacccaggca aacgtctggg ttgtggacct gaaggcgaac gtgatatcaa 1921 agagcatgca ttttcccgqt atattgattg ggagaaactt gaacgcaaag agatccagcc 1981 cccttataag ccaaaagctt gtgggcgaaa tgctgaaaac ttcgaccgat ttttcacccg 2041 ccatccacca gtcctaacac ctcccgacca ggaagtcatc aggaatattg accaatcaga 2101 attcgaagga ttttcccttg ttaactctga atttttaaaa cccgaagtca agagctaagt WO 00/09525 1317 PCT/US99/17712 2161 agatgtgtag atctccgtcc ttcatttctg tcattcaagc tcaacggcta ttgtggtgac 2221 atttttatgt ttttcattgc caagttgcat ccatgtttga ttttctgatg agactagagt 2281 gacagtgttt cagaacccaa atgtcctcag gtagtttgga gcatctctat gagatgggat 2341 tatgcagatg gcctatggaa aatgcagctg cataattaac acattatcaa agtcctctta 2401 caatttattt tccgcagcat gtcagctaag tagacccaat ggggagagaa aatgcctgct 2461 ttctttccct ctttttctgc actgccatat tcacccccaa ccatccaatc tgtggataat 2521 tggatgttag cggtactctt ccacttccgg tcctggagct tggcttgtat ccaagtgtat 2581 ggttgctttg cctaagagga atccctctat ttcacctgtt ctggaggcac cagaccttga 2641 aaagaacatg ctcaaaataa aatgttatct gttatttttg taaactcaaa gttaagatga 2701 tcaaagttct aaaattccaa gaatgtgctt ttagacggtc tcaatctaaa agcacttcaa 2761 ggggtcaaag ggcaaccagc ttggtgctac ctcagtgttg tagtttctga tactttatgt 2821 ctttgctcac cctcatcccc aaactacttg aaaagggcat ttggcaccac tctctgaaac 2881 aacacagtca ctctagcaag gcccccaaag ggccctggtt ttacattaca tttcaaactt 2941 tatttgcttt ggggttttgt ttctgttgtt gttcaaatgc aaaaaaaaga aaaaaaaaag 3001 aaaaaaaaag gtgactcaca ttgttacaca tgctttaaaa tatgtgttca aatgttatta 3061 accacaatga cgacctgttt tgatttaacc aagaagacgg ctgcggagcc tagcagactc 3121 aggcctgtgg gaatgggatt tgttacaaat ctaggtttgt tactggcttc agaaagctaa 3181 ttaagtgctc tgaaaaagac accgtttctt gaaacaaaga tggttgtatt cctcactttg 3241 atgttgtttt gcaagatgtt tgtggaaatg ttcatttgta tctggatctc tgttatgtgc 3301 catttttctt ctagcatcga g 1 gtccttcatt ccttccacaa ctatttatcc agcaccgttt ctgggcacag ggctccagcg 61 atggtcccaa caggtacaat gacctctggg gaccaagttc agttcttggt gagttctcca 121 gtgcctctcg atgtaggatg aaccgttggc atgctccact gacgctggct ccttctgttg 181 tttctcttgg ctccaggacc cccgcagcaa acacaagttt aagatccaca cgtactccag 241 ccccacgttt tgtgaccact gtgggtcact gctgtatgga ctcatccacc aggggatgaa 301 atgtgacagt aagtactttc tctctctggg ggcatctgct gatggcagaa gcaatgggaa 361 gggctgcttc cacttggttt ggggtccagg tctgccatac attcccccct gtcctcgttg 421 gggctggtgt accagttatc tgttgctgca taatgatcct cccaccccaa aacactgtga 481 ctgaagacaa taaacatttt tttagctcat gactctgcaa ggcagtcctt tgaatctggg 541 ctggcctcag ctgatgtcac gcatgttcat aaagcatgaa ctcatggttc atggtggatt 601 agcagatgga ggtgggctgg g 1 acatcaagga gacgagtcct ggttggatag taatgtcttt aacacccctc tagcatttat 61 taatttcctc tcttaacaaa taaaagatgc ccttcagtca gatgcttagg acagatgacg 121 cacctagaga tattttaata atgtagatac tcttgctgtt caaactcaga ccaaaatgac 181 gataggcttt tttggccccc agagggtgca caaatacgac cagaatttgt gaagacgagt 241 cagaaatgaa tgaaatttgg aaaaatattg atctactgaa atccttcctc cccacactat 301 tagccctatg ttacagttgg ggaaacggag tcgttttgca gaggggatgg acagaaggta 361 gggagttctc ttccaaacgt gcaggaggca agcaaagcca agaatcttct ctgtggtgag 421 ttagagacat ataaaataaa gatcgctcct cccctacctc tgcagaacgt gtgtgtgtat 481 gtgtgtgtaa gtgtgtgcgg ccacaagcct ttccgaatga gtgacagcgg gagcccatcc 541 ctccaggaga cgcgtgcaga atgaccaatg ggatggatgg gggtggatgg gtaccagtct 601 ccgcagaggc cggggtggga attcgctgcg ccccacccct tccacccgct ccccttcgcc 661 ccgtaggtct ttccactctc gctcctcccc tgggcacatc tcctgaacgc agccccgggg 721 gccgaggacg gggtggggtg gggggcgagg ctcgggtccg acgaccccgg gctgcggtcc 781 cggcgctgca gagctgcggc tgtgcacgct tagccgcgag gcccgcggta gcccgggcgc 841 cgatatgtaa agcagctggc agcgctgggc ggggcctggg cgcgactgca aatgaqgagg 901 gcgcgggctg gcccgggggc tccgcctccc tcccccgcag ctggggccag cggctgccaa 961 gcgcactggt cgagcggcag cagctgggcg aggtgacagc cccggctccg cgcgccggcc 1021 gccagagccg gcgcagggga agcgcccgcg gccccgggtg cagcagcggc cgccgcctcc 1081 cgcgcctccc cggcccgcag cccgcggtcc cgcgccccgg ggccggcacc tctcgggctc 1141 cggctccccg cgcgcaagat ggctgacccg gctgcggggc cgccgccgag cgagggcgag 1201 gagagcaccg tgcgcttcgc ccgcaaaggc gccctcaggc agaagaacgt gcatgaggtc 1261 aagaaccaca aattcaccgc ccgcttcttc aagcagccca ccttctgcag ccactgcacc 1321 gacttcatct ggtgaccccc caggcactcc ggccccaggc cacgccgcgc caggaccccc 1381 tctccgcgcc ctctgcgccc tccgcaccct ggaccccgcg tccccggact ccccgctccg 1441 gaccctgctg cccgggactc ccggatggac agtcctagcc gttgccctgt ccccaccctg 1501 gtcccagacg ggccgccgcg ggcgcctcct gccctctcct gctctcaggc gcctctaga 1gtcgactgca ggtcaacgga cacatcaagg agagagtcct ggttggatag taatgtcttt 61 aacacccctc tagcatttat taatttcctc tcttaacaaa taaaagatga cttcagttga 121 agatccttag gacaatgac ggcacctgga gatattttaa taatgtagat accctcttgc 181 tgttcaaact cagaccaaaa gagatggctt tttttccccc agagggtgca caaatacgac 241 agaatttgtg aagacgagtc agaaatgaat gaaatttgga aaaatattga tctactgaaa 301 tccttcctcc ccacactatt agccctatgt tacagttggg gaaacggagt cgttttgcag 361 aggggatgga cagaaggtag ggagttctct tccaacgtgc aggaggcaag caaagccaag 421 catcttctct gtggtggagt tagagacata taaaataaga tcgctcctcc cctacctctg 481 cagaacgtgt gtgtgtatgt gtgtgtaacg tgtgtgcggc cacaagcctt tccgaatgag 541 tgacagcggg agcccatccc tccaggagac gcgtgcagaa tgaccaatgg gaggatggg 601 ggtggatggg taccgctcc gcgaggccgg ggtggaattc gctgcgcccc accccttcca WO 00/09525 1318 PCT/US99/17712 661 cccgctcccc ttcgccccgt aggtctttcc actctcgctc ctcccctggg cacatctcct 721 gaacgcagcc ccgggggccg aggacggggt ggggtggggg gcgaggctcg ggtccgacga 781 ccccgggctg cggtcccggc gctgcagagc tgcggctgtg cacgcttagc cgcgaggccc 841 gcggtagccc gggcgccgat atgtaaagca gctggcagcg ctgggcgggg cctgggcgcg 901 atgcaaatga ggagggcggg gctggcccgg ggctccgcct ccctcccccg cagctggggc 961 cagcggtgcc aagcgcagct ggacgagcgg cagcagctgg gcgagtgaca gccccggctc 1021 cgcgcgccgc ggccgccaga gccggcgcag gggaagcgcc cgcggccccg ggtgcagcag 1081 cggccgccgc ctcccgcgcc tccccggccc gcagcccgcg gtcccgcggc cccggggccg 1141 gcacctctcg ggctccggct ccccgcgcgc aagatggctg acccggctgc ggggccgccg 1201 ccgagcgagg gcgaggagag caccgtgcgc ttcgcccgca aaggcgccct caggcagaag 1261 aacgtgcatg aggtcaagaa ccacaaattc accgcccgct tcttcaagca gcccaccttc 1321 tgcagccact gcaccgactt catctggtgg agcgcgcgcg caaggcacct tcccgggccc 1381 ccgaggcagc gccgcgccaa gggaccccct ctccgccctc tgcgccctcc gcaccctgga 1441 ccccgcgtcc ccggactccc cgctccggac cctgctgccg ggactcccgg atggacagtc 1501 ctgccgttgc cctgtcccca ccctggtccc aggacggggg cgcctcctgc cctctcctgc 1561 tctcaggcgc ctctagagcg cccaggggca gcgtcgcggg cgcctttgct ccacctgact 1621 aggagcgcgc ggggtctgtg cctgccctgg agggcagcgc ctcgggtgct ctccgacccg 1681 gggttcccta tctctccgcc tgcttccggg cgcgaggagc cctcgccccc caccccttgt 1741 ttccgggggg ggggggcggc gccctgggtg tccttctcta tctctgcggg catgggacat 1801 cctttctcac tcctctgtgc ctcggcagcg ccctgtgtta tctcccattg ccctccccga 1861 gggcctggtt cccctttcca ctcctcggtc acatcactgc gggccccttt cttccccagt 1921 ccctccagta gtggggcatc ctttcctcct tcccagtccc cctcccagag gacaccaccg 1981 ccgcggggtc actctcgccc tccctctgaa tgcgtcttta tctcttctct tttccgaggg 2041 tgctcggggc atctatgggt acatctgtcg cctgccttca gcccctaccc cgacggaaac 2101 gctccccact atcccgccac ctggtggtcg cagcctcctc tcttctgcag gagtgaaggc 2161 agatcggggt tacagccgag ctcccaccta cccccacaaa ggcggaagac tcttgggcac 2221 ccgcctgtgg ctgggagttt gcacctgggg tacagaggca gggaggaagg cgggtgactc 2281 tgtgggtaac tagctggagg ctgggccccc gggctgcctg acatacacct ccttctgctt 2341 ttgcaggggc ttcgggaagc agggattcca gtgccaaggt aggctctggg gctttgggga 2401 tgctatttgt gggaagagag ggtgaaaaat actttataga agaagttact gagttaggca 2461 gagagtgaaa gaatcacgtt ggtcggagtg acctcccagg ctaggaattc 1aaagcgacca tgtatcctga gtggaagtcg acgttcgatg cccacatcta tgaggggcgc 61 gtcatccaga ttgtgctaat gcgggcagca gaggagccag tgtctgaggt gaccgtgggt 121 gtgtcggtgc tggccgagcg ctgcaagaag aacaatggca aggctgagtt ctggctggac 181 ctgcagcctc aggccaaggt gttgatgtct gttcagtatt tcctggagga cgtggattgc 241 aaacagtcta tgcgcagtga ggacgaggcc aagttcccaa cgatgaaccg ccgcggagcc 301 atcaaacagg ccaaaatcca ctacatcaag aaccatgagt ttatcgccac cttctttggg 361 caacccacct tctgttctgt gtgcaaagac tttgtctggg gcctcaacaa gcaaggctac 421 aaatgcaggc aatgtaacgc tgccatccac aagaaatgca tcgacaagat catcggcaga 481 tgcactggca ccgcggccaa cagccgggac actatattcc agaaagaacg cttcaacatc 541 gacatgccgc accgcttcaa ggttcacaac tacatgagcc ccaccttctg tgaccactgc 601 ggcagcctgc tctggggact ggtgaagcag ggattaaagt gtgaagactg cggcatgaat 661 gtgcaccata aatgccggga gaaggtggcc aacctctgcg gcatcaacca gaagcttttg 721 gctgaggcct tgaaccaagt cacccagaga gcctcccgga gatcagactc agcctcctca 781 gagcctgttg ggatatatca gggtttcgag aagaagaccg gagttgctgg ggaggacatg 841 caagacaaca gtgggaccta cggcaagatc tgggagggca gcagcaagtg caacatcaac 901 aacttcatct tccacaaggt cctgggcaaa ggcagcttcg ggaaggtgct gcttggagag 961 ctgaagggca gaggagagta ctttgccatc aaggccctca agaaggatgt ggtcctgatc 1021 gacgacgacg tggagtgcac catggttgag aagcgggtgc tgacacttgc cgcagagaat 1081 ccctttctca cccacctcat ctgcaccttc cagaccaagg accacctgtt ctttgtgatg 1141 gagttcctca acggggggga cctgatgtac cacatccagg acaaaggccg ctttgaactc 1201 taccgtgcca cgttttatgc cgctgagata atgtgtggac tgcagtttct acacagcaag 1261 ggcatcattt acagggacct caaactggac aatgtgctgt tggaccggga tggccacatc 1321 aagattgccg actttgggat gtgcaaagag aacatattcg gggagagccg ggccagcacc 1381 ttctgcggca cccctgacta tatcgcccct gagatcctac agggcctgaa gtacacattc 1441 tctgtggact ggtggtcttt cggggtcctt ctgtacgaga tgctcattgg ccagtccccc 1501 ttccatggtg atgatgagga tgaactcttc gagtccatcc gtgtggacac gccacattat 1561 ccccgctgga tcaccaagga gtccaaggac atcctggaga agctctttga aagggaacca 1621 accaagaggc tgggagtgac gggaaacatc aaaatccacc ccttcttcaa gaccataaac 1681 tggactctgc tggaaaagcg gaggttggag ccacccttIca ggcccaaagt gaagtcaccc 1741 agagactaca gtaactttga ccaggagttc ctgaacgaga aggcgcgcct ctcctacagc 1801 gacaagaacc tcatcgactc catggaccag tctgcattcg ctggcttctc ctttgtgaac 1861 cccaaattcg agcacctcct ggaagattga ggttcctgga cagatcaggc tagccctgcc 1921 ctccacccac acctgcccgc tccccacgat aagcaccagt gggactgtgg tgacttctgc 1981 tgctggcccc gcccctgccc ccagagcgtc cttggctgcc gtctggccgg gctctcatgg 2041 tacttcctct gtgaactutg tgtgaatctg cttttcctct gccttcggag ggaaattgta 2101 aatcctgtgt ttcattactt gaatgtagtt atctattgaa aatatacttt agagcacaat 2161 gga WO 00/09525 1319 PCT/US99/17712 1 tgccgccgcg acccttggcg cctgcccctg caacgggagc cccactgcag gccccaccat 61 ggcgccgttc ctgcgcatcg ccttcaactc ctatgagctg ggctccctgc aggccgagga 121 cgaggcgaac cagcccttct gtgccgtgaa gatgaaggag gcgctcagca cagagcgtgg 181 gaaaacactg gtgcagaaga agccgaccat gtatcctgag tggaagtcga cgttcgatgc 241 ccacatctat gaggggcgcg tcatccagat tgtgctaatg cgggcagcag aggagccagt 301 gtctgaggtg accgtgggtg tgtcggtgct ggccgagcgc tgcaagaaga acaatggcaa 361 ggctgagttc tggctggacc tgcagcctca ggccaaggtg ttgatgtctg ttcagtattt 421 cctggaggac gtggattgca aacaatctat gcgcagtgag gacgaggcca agttcccaac 481 gatgaaccgc cgcggagcca tcaaacaggc caaaatccac tacatcaaga accatgagtt 541 tatcgccacc ttctttgggc aacccacctt ctgttctgtg tgcaaagact ttgtctgggg 601 cctcaacaag caaggctaca aatgcaggca atgtaacgct gccatccaca agaaatgcat 661 cgacaagatc atcggcagat gcactggcac cgcggccaac agccgggaca ctatattcca 721 gaaagaacgc ttcaacatcg acatgccgca ccgcttcaag gttcacaact acatgagccc 781 caccttctgt gaccactgcg gcagcctgct ctggggactg gtgaagcagg gattaaagtg 841 tgaagactgc ggcatgaatg tgcaccataa atgccgggag aaggtggcca acctctgcgg 901 catcaaccag aagcttttgg ctgaggcctt gaaccaagtc acccagagag cctcccggag 961 atcagactca gcctcctcag agcctgttgg gatatatcag ggtttcgaga agaagaccgg 1021 agttgctggg gaggacatgc aagacaacag tgggacctac ggcaagatct gggagggcag 1081 cagcaagtgc aacatcaaca acttcatctt ccacaaggtc ctgggcaaag gcagcttcgg 1141 gaaggtgctg cttggagagc tgaagggcag aggagagtac tctgccatca aggccctcaa 1201 gaaggatgtg gtcctgatcg acgacgacgt ggagtgcacc atggttgaga agcgggtgct 1261 gacacttgcc gcagagaatc cctttctcac ccacctcatc tgcaccttcc agaccaagga 1321 ccacctgttc tttgtgatgg agttcctcaa cgggggggac ctgatgtacc acatccagga 1381 caaaggccgc tttgaactct accgtgccac gttttatgcc gctgagataa tgtgtggact 1441 gcagtttcta cacagcaagg gcatcattta cagggacctc aaactggaca atgtgctgtt 1501 ggaccgggat ggccacatca agattgccga ctttgggatg tgcaaagaga acatattcgg 1561 ggagagccgg gccagcacct tctgcggcac ccctgactat atcgcccctg agatcctaca 1621 gggcctgaag tacacattct ctgtggactg gtggtctttc ggggtccttc tgtacgagat 1681 gctcattggc cagtccccct tccatggtga tgatgaggat gaactcttcg agtccatccg 1741 tgtggacacg ccacattatc cccgctggat caccaaggag tccaaggaca tcctggagaa 1801 gctctttgaa agggaaccaa ccaagaggct gggaatgacg ggaaacatca aaatccaccc 1861 cttcttcaag accataaact ggactctgct ggaaaagcgg aggttggagc cacccttcag 1921 gcccaaagtg aagtcaccca gagactacag taactttgac caggagttcc tgaacgagaa 1981 ggcgcgcctc tcctacagcg acaagaacct catcgactcc atqgaccagt ctgcattcgc 2041 tggcttctcc tttgtgaacc ccaaattcga gcacctcctg gaagattgag gttcctggac 2101 agat cccaagatgg aagggagcgg cggccgcgtc cgcctcaagg cgcattacgg gggggacatc 61 ttcatcacca gcgtggacgc cgccacgacc ttcgaggagc tctgtgagga agtgagagac 121 atgtgtcgtc tgcaccagca gcacccgctc accctcaagt gggtggacag cgaaggtgac 181 ccttgcacgg tgtcctccca gatggagctg gaagaggctt tccgcctggc ccgtcagtgc 241 agggatgaag gcctcatcat tcatgttttc ccgagcaccc ctgagcagcc tggcctgcca 301 tgtccgggag aagacaaatc tatctaccgc cggggagcca gaagatggag gaagctgtac 361 cgtgccaacg gccacctctt ccaagccaag cgctttaaca ggagagcga ctgcggtcag 421 tgcagcgaga ggatatgggg cctcgcgagg caaggctaca ggtgcatcaa ctgcaaactg 481 ctggtccata agcgctgcca cggcctcgtc ccgctgacct gcaggaagca tatggattct 541 gtcatgcctt cccaagagcc tccagtagac gacaagaacg aggacgccga ccttccttcc 601 gaggagacag atggaattgc ttacatttcc tcatcccgga agcatgacag cattaaagac 661 gactcggagg accttaagcc agttatcgat gggatggatg gaatcaaaat ctctcagggg 721 cttgggctgc aggactttga cctaatcaga gtcatcgggc gcgggagcta cgccaaggtt 781 cacctggtgc ggttgaagaa gaatgaccaa atttaccca tgaaagtggt gaagaaagag 841 ctggtgcatg atgacgagga tattgactgg gtacagacag agaagcacgt gtttgagcag 901 gcatccagca accccttcct ggtcggatta cactcctgct tccagacgac aagtcggttg 961 ttcctggtca ttgagtacgt caacggcggg gacctgatgt tccacatgca gaggcagagg 1021 aagctccctg aggagcacgc caggttctac gcggccgaga tctgcatcgc cctcaacttc 1081 ctgcacgaga gggggatca ctacagggac ctgaagctgg acaacgtcct cctggatgcg 1141 gacgggcaca tcaagctcac agactacggc atgtgcaagg aaggcctggg ccctggtgac 1201 acaacgagca ctttctgcgg aaccccgaat tacatcgccc ccgaaatcct gcggggagag 1261 gagtacgggt tcagcgtgga ctggtgggcg ctgggagtcc tcatgtttga gatgatggcc 1321 gggcgctccc cgttcgacat catcaccgac aacccggaca tgaacacaga ggactacctt 1381 ttccaagtga tcctggagaa gcccatccgg atcccccggt tcctgtccgt caaagcctcc 1441 catgttttaa aaggattttt aaataaggac cccaaagaga ggctcggctg ccggccacag 1501 actggatttt ctgacatcaa gtcccacgcg ttcttccgca gcatagactg ggacttgctg 1561 gagaagaagc aggcgctccc tccattccag ccacagatca cagacgacta cggtctggac 1621 aactttgaca cacagttcac cagcgagccc gtgcagctga ccccagacga tgaggatgcc 1681 ataaagagga tcaaccagtc agagttcgaa ggccttgagt atatcaaccc attattgctg 1741 tccaccgagg agtcggtgg aggccgcgtg cgtctctgtc gtggacacgc gtgattacc 1801 ctttaactgt atcctaacc accacatatg catgccaggc tgggcacggc tccgagggcg 1861 gccagggaca gacgcttgcg ccgagaccgc agagggaagc gtcagcgggc gctgctggga WO 00/09525 1320 PCT/US99/17712 1921 gcagaacagt ccctcacacc tggcccggca ggcagcttcg tgctggagga acttgctgct 1981 gtgcctgcgt cgcggcggat ccgcggggac cctgccgagg gggctgtcat gcggtttcca 2041 aggtgcacat tttccacgga aacagaactc gatgcactga cctgctccgc caggaaagtg 2101 agcgtgtagc gtcctgagga ataaaatgtt ccgatgaaaa aaaaaa 1 gggccggcgg cggcggcgac tctggacgcg agccgggccc ttcccgtgga tcgccccagc 61 tgcggcgggc gtcgcggccg cccccgggtg gcacttccgt gtgccgcggc gccggagccc 121 gaggcggctg tagcccacat ctcccgagcg acccccggcg cccgcccgcc gcgcggaggc 181 ccgggccaca cctcactggc cgcttggccc atcccagtca gcgccgcgcc gaaccccgtc 241 cgcgcgcgcc ggggagcggc gcccccgccg ctgccgccgc gacccttggc gcctgcccct 301 gcaacgggag ccccactgca ggccccacca tggcgccgtt cctgcgcatc gccttcaact 361 cctatgagct gggctccctg caggccgagg acgaggcgaa ccagcccttc tgtgccgtga 421 agatgaagga ggcgctcagc acagagcgtg ggaaaacact ggtgcagaag aagccgacca 481 tgtatcctga gtggaagtcg acgttcgatg cccacatcta tgaggggcgc gtcatccaga 541 ttgtgctaat gcgggcagca gaggagccag tgtctgaggt gaccgtgggt gtgtcggtgc 601 tggccgagcg ctgcaagaag aacaatggca aggctgagtt ctggctggac ctgcagcctc 661 aggccaaggt gttgatgtct gttcagtatt tcctggagga cgtggattgc aaacagtcta 721 tgcgcagtga ggacgaggcc aagttcccaa cgatgaaccg ccgcggagcc atcaaacagg 781 ccaaaatcca ctacatcaag aaccatgagt ttatcgccac cttctttggg caacccacct 841 tctgttctgt gtgcaaagac tttgtctggg gcctcaacaa gcaaggctac aaatgcaggc 901 aatgtaacgc tgccatccac aagaaatgca tcgacaagat catcggcaga tgcactggca 961 ccgcggccaa cagccgggac actatattcc agaaagaacg cttcaacatc gacatgccgc 1021 accgcttcaa ggttcacaac tacatgagcc ccacctictg tgaccactgc ggcagcctgc 1081 tctggggact ggtgaagcag ggattaaagt gtgaagactg cggcatgaat gtgcaccata 1141 aatgccggga gaaggtggcc aacctctgcg gcatcaacca gaagcttttg gctgaqgcct 1201 tgaaccaagt cacccagaga gcctcccgga gatcagactc agcctcctca gagcctgttg 1261 ggatatatca gggtttcaag aagaagaccg gagttgctgg ggaggacatg caagacaaca 1321 gtgggaccta cggcaagatc tgggagggca gcagcaagtg caacatcaac aacttcatct 1381 tccacaaggt cctgggcaaa ggcagcttcg ggaaggtgct gCt 1 ctccccgccc cgaccatggt agtgttcaat ggccttctta agatcaaaat ctgcgaggcc 61 gtgagcttga agcccacagc ctggtcgctg cgccatgcgg tgggaccccg gccgcagact 121 ttccttctcg acccctacat tgccctcaat gtggacgact cgcgcatcgg ccaaacggcc 181 accaagcaga agaccaacag cccggcctgg cacgacgagt tcgtcaccga tgtgtgcaac 241 ggacgcaaga tcgagctggc tgtctttcac gatgccccca taggctacga cgacttcgtg 301 gccaactgca ccatccagtt tgaggagctg ctgcagaacg ggagccgcca cttcgaggac 361 tggattgatc tggagccaga aggaagagtg tatgtgatca tcgatctctc agggtcgtcg 421 ggtgaagccc ctaaagacaa tgaagagcgt gtgttcaggg aacgcatgcg gccgaggaag 481 cggcaggggg ccgtcaggcg cagggtccat caggtcaacg gccacaagtt catggccacc 541 tatcttcggc agcccaccta ctgctcccat tgcagagact tcatctgggg tgtcatagga 601 aagcagggat accagtgtca agtctgcacc tgcgtggtcc acaagcggtg ccacgagctc 661 ataatcacaa agtgtgctgg gttaaagaag caggagaccc ccgaccaggt gggctcccag 721 cggttcagcg tcaacatgcc ccacaagttc ggtatccaca actacaaggt ccctaccttc 781 tgcgatcaci gtgggtccct gctctgggga ctcttgcggc agggtttgca gtgtaaagtc 841 tgcaaaatga atgttcaccg tcgatgtgag accaacgtgg ctcccaactg tggagtggat 901 gccagaggaa tcgccaaagt actggccgac ctgggcgtta ccccagacaa aatcaccaac 961 agcggccaga gaaggaaaaa gctcattgct ggtgccgagt ccccgcagcc tgcttctgga 1021 agctcaccat ctgaggaaga tcgatccaag tcagcaccca cctccccttg tgaccaggaa 1081 ataaaagaac ttgagaacaa cattcggaaa gccttgtcat ttgacaaccg aggagaggag 1141 caccgggcag catcgtctcc tgatggccag ctgatgagcc ccggtgagaa tggcgaagtc 1201 cggcaaggcc aggccaagcg cctgggcctg gatgagttca acttcatcaa ggtgttgggc 1261 aaaggcagct ttggcaaggt catgttggca gaactcaagg gcaaagatga agtatatgct 1321 gtgaaggtct taaagaagga cgtcatcctt caggatgatg acgtggactg cacaatgaca 1381 gagaagagga ttttggctct ggcacggaaa cacccgtacc ttacccaact ctactgctgc 1441 ttccagacca aggaccgcct ctttttcgtc atggaatatg taaatggtgg agacctcatg 1501 tttcagattc agcgctcccg aaaattcgac gagcctcgtt cacggttcta tgctgcagag 1561 gtcacatcgg ccctcatgtt cctccatcag catggagtca tctacaggga tttgaaactg 1621 gacaacatcc ttctggatgc agaaggtcac tgcaagctgg ctgacttcgg gatgtgcaag 1681 gaagggattc tgaatggtgt gacgaccacc acgttctgtg ggactcctga ctacatagct 1741 cctgagatcc tgcaggagtt ggagtatggc ccctccgtgg actggtgggc cctgggggtg 1801 ctgatgtacg agatgatggc tggacagcct ccctttgagg ccgacaatga ggacgaccta 1861 tttgagtcca tcctccatga cgacgtgctg tacccagtct ggctcagcaa ggaggctgtc 1921 agcatcttga aagctttcat gacgaagaat ccccacaagc gcctgggctg tgtggcatcg 1981 cagaatggcg aggacgccat caagcagcac ccattcttca aagagattga ctgggtgctc 2041 ctggagcaga agaagatcaa gccacccttc aaaccacgca ttaaaaccaa aagagacgtc 2101 aataattttg accaagactt tacccgggaa gagccggtac tcacccttgt ggacgaagca 2161 attgtaaagc agatcaacca ggaggaattc aaaggtttct cctactttgg tgaagacctg 2221 atgccctgag agcccactgc agtt 1 agccggcttc tcgaaactcc ctgtgtgagt gtgagggaat gagtatgaac aaggcacatt 61 atgtcttact tattatatta gtttcctgtt gctgctgtag caagttacca ccaatttatt WO 00/09525 1321 PCT/US99/17712 121 gcttaaagca attcaaattt tttctcttga attcttaaga tcagaagttc taaatgagtc 181 taatggggct aaaatcaagg tgttaggcaa aggcagct 1 tgcagctgga gatccgggct cccacagcag atgagatcca cgtaactgtt ggcgaggccc 61 gtaacctaat tcctatggac cccaatggtc tctctgatcc ctatgtgaaa ctgaagctca 121 tcccagaccc tcggaacctg acgaaacaga agacccgaac ggtgaaagcc acgctaaacc 181 ctgtgtggaa tgagaccttt gtgttcaacc tgaagccagg ggatgtggag cgccggctca 241 gcgtggaggt gtgggactgg gaccggacct cccgcaacga cttcatgggg gccatgtcct 301 ttggcgtctc ggagctgctc aaggcgcccg tggatggctg gtacaagtta ctgaaccagg 361 aggagggcga gtattacaat gtgccggtgg ccgatgctga caactgcagc ctcctccaga 421 agtttgaggc ttgtaactac cccctggaat tgtatgagcg ggtgcggatg ggcccctctt 481 cctctcccat cccctcccct tcccctagtc ccaccgaccc caagcgctgc ttcttcgggg 541 cgagtccagg acgcctgcac atctccgact tcagcttcct catggttcta ggaaaaggca 601 gttttgggaa ggtgatgctg gccgagcgca ggggctctga tgagctctac gccatcaaga 661 tcttgaaaaa ggacgtgatc gtccaggacg acgatgtgga ctgcacgctg gtggagaaac 721 gtgtgctggc gctggggggc cggggtcctg gcggccggcc ccacttcctc acccagctcc 781 actccacctt ccagaccccg gaccgcctgt atttcgtgat ggagtacgtc accgggggag 841 acttgatgta ccacattcaa cagctgggca agtttaagga gccccatgca gcgttctacg 901 cggcagaaat cgctatcggc ctcttcttcc ttcacaatca gggcatcatc tacagggacc 961 tgaagctgga caatgtgatg ctggatgctg agggacacat caagatcact gactttggca 1021 tgtgtaagga gaacgtcttc cccgggacga caacccgcac cttctgcggg accccggact 1081 acatagcccc ggagatcatt gcctaccagc cctatgggaa gtctgtcgat tggtggtcct 1141 ttggagttct gctgtatgag atgttggcag gacagcctcc cttcgatggg gaggacgagg 1201 aggagctgtt tcaggccatc atggaacaaa ctgtcaccta ccccaagtcg ctttcccggg 1261 aagccgtggc catctgcaag gggttcctga ccaagcaccc agggaagcgc ctgggctcag 1321 ggcctgatgg ggaacctacc atccgtgcac atggcttttt ccgctggatt gactgggagc 1381 ggctggaacg attggagatc ccgcctcctt tcagaccccg cccgtgtggc cgcagcggcg 1441 agaactttga caagttcttc acgcgggcgg cgccagcgct gacccctcca gaccgcctag 1501 tcctggccag catcgaccag gccgatttcc agggcttcac ctacgtgaac cccgacttcg 1561 tgcacccgga tgcccgcagc cccaccagcc cagtgcctgt gcccgtcatg taatctcacc 1621 cgccgccact aggtgtcccc aacgtcccct ccgccgtgcc ggcggcagcc ccacttcacc 1681 cccaacttca ccaccccctg tcccattcta gatcctgcac cccagcattc cagctctgcc 1741 cccgcgggtt ctagacgccc ctcccaagcg ttcctggcct tctgaactcc atacagcctc 1801 tacagccgtc ccgcgttcaa gacttgagcg cggggtgtct tgggcccggg cggctgtaga ggcggcggcg cctacgggca gtgggaggaq 61 ccgcgcggtt ccggctgctc cggcgaggcg acccttgggt cggcgctgcg ggcaggtggc 121 aggtaggtgg cggacggccg cggttctccg gcaagcgcag gcggcggagt cccccacggc 181 gcccgaagcg cccccccgca cccccggcct ccagcgttga ggcgggggag tgaggagatg 241 ccgacccaga gggacagcag caccatgtcc cacacggtcg caggcggcgg cagcggggac 301 cattcccacc aggtccgggt gaaagcctac taccgcgggg atatcatgat aacacatttt 361 gaaccttcca tctcctttga gggcctttgc aatgaggttc gagacatgtg ttcttttgac 421 aacgaacagc tcttcaccat gaaatggata gatgaggaag gagacccgtg tacagtatca 481 tctcagttgg agttaaaaga agcctttaga ctttatgagc taaacaagga ttctgaactc 541 ttgattcatg tgttcccttg tgtaccagaa cgtcctggga tccttgtcc aggagaagat 601 aaatccatct accgtagagg tgcacaccgc tggagaaagc tttattgtgc caatggccac 661 actttccaag ccaagcgttt caacaggcgt gctcactgtg ccatctgcac agaccgaata 721 tggggacttg gacgccaagg atataagtgc atcaactgca aactcttggt tcataagaag 781 tgccataaac tcgtcacaat tgaatgtggg cggcattctt tgccacagga accagtgatg 841 cccatggatc agtcatccat gcattctgac catgcacaga cagtaattcc atataatcct 901 tcaagtcatg agagtttgga tcaagttggt gaagaaaaag aggcaatgaa caccagggaa 961 agtggcaaaq cttcatccag tctaggtctt caggattttg atttgctccg ggtaatagga 1021 agaggaagtt atgccaaagt actgttggtt cgattaaaaa aaacagatcg tatttatgca 1081 atgaaagttg tgaaaaaaga gcttgttaat gatgatgagg atattgattg ggtacagaca 1141 gagaagcatg tgtttgagca ggcatccaat catcctttcc ttgttgggct gcattcttgc 1201 tttcagacag aaagcagatt gttctttgtt atagagtatg taaatggagg agacctaatg 1261 tttcatatgc agcgacaaag aaaacttcct gaagaacatg ccagatttta ctctgcagaa 1321 atcagtctag cattaaatta tcttcatgag cgagggataa tttatagaga tttgaaactg 1381 gacaatgtat tactggactc tgaaggccac attaaactca ctgactacgg catgtgtaag 1441 gaaggattac ggccaggaga tacaaccagc actttctgtg gtactcctaa ttacattgct 1501 cctgaaattt taaaaggaga agattatggt ttcagtgttg actggtgggc tcttggagtg 1561 ctcatgtttg agatgatggc aggaaggtct ccatttgata ttgttgggag ctccgataac 1621 octgaccaga acacagagga ttatctcttc caagttattt tggaaaaaca aattcgcata 1681 ccacgttctc gtctgtaaa agccgcaagt gttctgaaga gttttcttaa ctaaggaccct 1741 aaggaacgat tgggttgtca tcctcaaaca ggatttgctg atattcaggg acacccgttc 1801 ttccgaaatg ttgattggga tatgatggag caaaaacagg tggtacctcc ctttaaacca 1861 aatatttctg gggaatttgg tttggacaac tttgattctc agtttactaa tgaacctgtc 1921 cagctcactc cagatgacga tgacattgtg aggaagattg atcagtctga atttgaaggt 1981 ttgagtata tcaatcctct tttgatgtct gcagaagaat gtgtctgatc ctcatttttc 2041 aaccatgtat tctactcatg ttgccattta atgcatggat aaacttgctg caagcctgga WO 00/09525 1322 PCT/US99/17712 2101 tacaattaac cattttatat ttgccaccra caaaaaaaca cccaatatct tctcttgtag 2161 actatatgaa tcaattatta catctcgacc cggaat 1 gaattcggac ggaggaggca gaatggccag tcgaggggcg cttaggcgtg gcctttcccc 61 agggctgcct cgactcctgc acctgtcccg agggctggcc tgagacggga ctcccggttc 121 tcccgctgcg aagcaggccc cccggggccg gggcagcggc gccggcatgt cgtctggcac 181 catgaagttc aatggctatt tgagggtccg catcggtgag gcagtggggc tgcagcccac 241 ccgctggtcc ctgcgccact cgctcttcaa gaagggccac cagctgctgg acccctatct 301 gacggtgagc gtggaccagg tgcgcgtggg ccagaccagc accaagcaga agaccaacaa 361 acccacgtac aacgaggagt tttgcgctaa cgtcaccgac ggcggccacc tcgagttggc 421 cgtcttccac gagacccccc tgggctacga cttcgtggcc aactgcaccc tgcagttcca 481 ggagctcgtc ggcacgaccg gcgcctcgga caccttcgag ggttgggtgg atctcgagcc 541 agaggggaaa gtatttgtgg taataaccct taccgggagt ttcactgaag ctactctcca 601 gagagaccgg atcttcaaac attttaccag gaagcgccaa agggctatgc gaaggcgagt 661 ccaccagatc aatggacaca agttcatggc cacgtatctg aggcagccca cctactgctc 721 tcactgcagg gagtttatct gggqagtgtt tgggaaacag ggttatcagt gccaagtgtg 781 cacctgtgtc gtccataaac gctgccatca tctaattgtt acagcctgta cttgccaaaa 841 caatattaac aaagtggatt caaagattgc agaacagagg ttcgggatca acatcccaca 901 caagttcagc atccacaact acaaagtgcc aacattctgc gatcactgtg gctcactgct 961 ctggggaata atgcgacaag gacttcagtg taaaatatgt aaaatgaatg tgcatattcg 1021 atgtcaagcg aacgtggccc ctaactgtgg ggtaaatgcg gtggaacttg ccaagaccct 1081 ggcagggatg ggtctccaac ccggaaatat ttctccaacc tcgaaactcg tttccagatc 1141 gaccctaaga cgacagggaa aggagagcag caaagaagga aatgggattg gggttaattc 1201 ttccaaccga cttggtatcg acaactttga gttcatccga gtgttgggga aggggagttt 1261 tgggaaggtg atgcttgcaa gagtaaaaga aacaggagac ctctatgctg tgaaggtgct 1321 gaagaaggac gtgattctgc tggatgatga tgtggaatgc accatgaccg agaaaaggat 1381 cctgtctctg gcccgcaatc accccttcct cactcagttg ttctgctgct ttcagacccc 1441 cgatcgtctg ttttttgtga tggagtttgt gaatgggggt gacttgatgt tccacattca 1501 gaagtctcgt cgttttgatg aagcacgagc tcgcttctat gctgcagaaa tcatttcggc 1561 tctcatgttc ctccatgata aaggaatcat ctatagagat ctgaaactgg acaatgtcct 1621 gttggaccac gagggtcact gtaaactggc agacttcgga atgtgcaagg aggggatttg 1681 caatggtgtc accacggcca cattctgtgg cacgccagac tatatcgctc cagagatcct 1741 ccaggaaatg ctgtacgggc ctgcagtaga ctggtgggca atgggcgtgt tgctctatga 1801 gatgctctgt ggtcacgcgc cttttgaggc agagaatgaa gatgacctct ttgaggccat 1861 actgaatgat gaggtggtct accctacctg gctccatgaa gatgccacag ggatcctaaa 1921 atctttcatg accaagaacc ccaccatgcg cttgggcagc ctgactcagg gaggcgagca 1981 cgccatcttg agacatcctt tttttaagga aatcgactgg gcccagctga accatcgcca 2041 aatagaaccg cctttcagac ccagaatcaa atcccgagaa gatgtcagta attttgaccc 2101 tgacttcata aaggaagagc cagttttaac tccaattgat gagggacatc ttccaatgat 2161 taaccaggat gagtttagaa acttttccta tgtgtctcca gaattgcaac catagcctta 2221 tggggagtga gagagagggc acgagaaccc aaaggaatag agattctcca ggaatttcct 2281 ctatcggacc ttcccagcat cagccttaga acaagaacct taccttcaag gagcaagtga 2341 agaactctgt cgaaggatgg aactttcaga tatcaactat ttagagtcc gaattccttc tctcctcctc ctcgcccttc tcctcgccct cctcctcctc ctcgccctcc 61 cctcccgatc ctcatcccct ggccctcccc cagcccaggg acttttccgg aaagttttta 121 ttttccgtct gggctctcgg agaaagaaac tcctggctca gcggctgcaa aactttcctg 181 ctgccgcgcc gccagccccc gccctccgct gcccggccct gcgccccgcc gagcgatgaq 241 cgcccctccg gtcctgcggc cgcccagtcc gctgctgccc gtggcggcgg cagctgccgc 301 agcggccgcc gcactggtcc cagggtccgg gcccgggccc gcgccgttct tggctcctgt 361 cgcggccccg gtcgggggca tctcgttcca tctgcagatc ggcctgagcc gtgagccggt 421 gctgctgctg caggactcgt ccggggacta cagcctggcg cacgtccgcg agatggcttg 481 ctccattgtc gaccagaagt tccctgaatg tggtttctac ggaatgtatg ataagatcct 541 gctttttcgc catgacccta cctctgaaaa catccttcag ctggtgaaag cggccagtga 601 tatccaggaa ggcgatctta ttgaagtggt cttgtcacgt tccgccacct ttgaagactt 661 tcagattcgt ccccacgctc tctttgttca ttcatacaga gctccagctt tctgtgatca 721 ctgtggagaa atgcttggg ggctggtacg tcaaggtctt aaatgtgaag ggtgtggtct 781 gaattaccat aagagatgtg catttaaaat acccaacaat tgcagcggtg tgaggcggag 841 aaggctctca aacgtttccc tcactggggt cagcaccatc cgcacatcat ctgctgaact 901 ctctacaagt gcccctgatg agccccttct gcaaaaatca ccatcagagt cgtttattgg 961 tctagagaag aggtcaaatt ctcaatcata cattggacga ccaattcacc ttgacaagat 1021 tttgatgtct aaagttaaag tgccgcacac atttgtcatc cactcctaca cccggcccac 1081 agtgtgccag tactgcaaga agcttctgaa ggggcttttc aggcagggct tgcagtgcaa 1141 agattgcaga ttcaactgcc ataaacgttg tgcaccgaaa gtaccaaaca actgccttgg 1201 cgaagtgacc attaatggag atttgcttag ccctggggca gagtctgatg tggtcatgga 1261 agaagggagt gatgacaatg atagtgaaag gaacagtggg ctcatggatg atatggaaga 1321 agcaatggtc caagatgcag agatggcaat ggcagagtgc cagaacgaca gtggcgagat 1381 gcaagatcca gacccagacc acgaggacgc caacagaacc atcagtccat caacaagcaa 1441 caatatccca ctcatgaggg tagtgcagtc tgtcaaacac acgaagagga aaagcagcac 1501 agtcatgaaa gaaggatgga tggtccacta caccagcaag gacacgctgc ggaaacggca WO 00/09525 1323 PCT/US99/17712 1561 ctattggaga ttggatagca aatgtattaC cctctttcag aatgacacag gaaacaggta 1621 ctacaaggaa attcctttat ctgaaatttt gtctctggaa ccagtaaaaa cttcagcttt 1681 aartcctaat ggggccaatc ctcattgttt cgaaatcact acggcaaatg tagtgtatta 1741 tgtgggagaa aatgtggtca atccttccag cccatcacca aataacagtg ttctcaccag 1801 tggcgttggt gcagatgtgg ccaggatgtg ggagatagcc atccagcatg cccttatgcc 1861 cgtcattccc aagggctcct ccgtgggtac aggaaccaac ttgcacagag atatctctgt 1921 gagtatttca gtatcaaatt gccagattca agaaaatgtg gacatcagca cagtatatca 1981 gatttttcct gatgaagtac tgggttctgg acagtttgga attgtttatg gaggaaaaca 2041 tcgtaaaaca ggaagagatg tagctattaa aatcattgac aaattacgat ttccaacaaa 2101 acaagaaagc cagcttcgta atgaggttgc aattctacag aaccttcatc accctggtgt 2161 tgtaaatttg gagtgtatgt ttgagacgcc tgaaagagtg tttgttgtta tggaaaaact 2221 ccatggagac atgctggaaa tgatcttgtc aagtgaaaag ggcaggttgc cagagcacat 2281 aacgaagttt ttaattactc agatactcgt ggctttgcgg caccttcatt ttaaaaatat 2341 cgttcactgt gacctcaaac cagaaaatgt gttgctagcc tcagctgatc cttttcctca 2401 ggtgaaactt tgtgattttg gttttgcccg gatcattgga gagaagtctt tccggaggtc 2461 agtggtgggt acccccgctt acctggctcc tgaggtccta aggaacaagg gctacaatcg 2521 ctctctagac atgtggtctg ttggggtcat catctatgta agcctaagcg gcacattccc 2581 atttaatgaa gatgaagaca tacacgacca aattcagaat gcagctttca tgtatccacc 2641 aaatccctgg aaggaaatat ctcatgaagc cattgatctt atcaacaatt tgctgcaagt 2701 aaaaatgaga aagcgctaca gtgtggataa gaccttgagc cacccttggc tacaggacta 2761 tcagacctgg ttagatttgc gagagctgga atgcaaaatc ggggagcgct acatcaccca 2821 tgaaagtgat gacctgaggt gggagaagta tgcaggcgag cagcggctgc agtaccccac 2881 acacctgatc aatccaagtg ctagccacag tgacactcct gagactgaag aaacagaaat 2941 gaaagccc ggtgagcgtg tcagcatcct ctgagttcca tctcctataa tctqtcaaaa 3001 cactgtggaa ctaataaata catacggtca ggtttaacat ttgccttgca gaactgccat 3061 tattttctgt cagatgagaa caaagctgtt aaactgttag cactgttgat gtatctgagt 3121 tgccaagaca aatcaacaga agcatttgta ttttgtgtga ccaactgtgt tgtattaaca 3181 aaagttccct gaaacacgaa acttgttatt gtgaatgatt catgttatat ttaatgcatt 3241 aaacctgtct ccactgtgcc tttgcaaatc agtgtttttc ttactggagc ttcattttgg 3301 taagagacag aatgtatctg tgaagtagtt ctgtttggtg tgtcccattg gtgttgtcat 3361 tgtaaacaaa ctcttgaaga gtcgattatt tccagtgttc tatgaacaac tccaaaaccc 3421 atgtgggaaa aaaatgaatg aggagggtag ggaataaaat cctaagacac aaatgcatga 3481 acaagtttta atgtatagtt ttgaatcctt tgcctgcctg gtgtgcctca gtatatttaa 3541 actcaagaca atgcacctag ctgtgcaaga cctagtgctc ttaagcctaa atgccttaga 3601 aatgtaaact gccatatata acagatacat ttccctcttt cttataatac tctgttgtac 3661 tatggaaaat cagctgctca gcaacctttc acctttgtgt atttttcaat aataaaaaat 3721 attcttgtca aaaaaaaaaa aa 1 tgctcgctcc agggcgcaac catgtcgcca tttcttcgga ttggcttgtc caactttgac 61 tgcgggtcct gccagtcttg tcagggcgag gctgttaacc cttactgtgc tgtgctcgtc 121 aaagagtatg tcgaatcaga gaacgggcag atgtatatcc agaaaaagcc taccatgtac 181 ccaccctggg acagcacttt tgatgcccat atcaacaagg gaagagtcat gcagatcatt 241 gtgaaaggca aaaacgtgga cctcatctct gaaaccaccg tggagctcta ctcgctggct 301 gagaggtgca ggaagaacaa cgggaagaca gaaatatggt tagagctgaa acctcaaggc 361 cgaatgctaa tgaatgcaag atactttctg gaaatgagtg acacaaagga catgaatgaa 421 tttgagacgg aaggcttctt tgctttgcat cagcgccggg gtgccatcaa gcaggcaaag 481 gtccaccacg tcaagtgcca cgagttcact gccaccttct tcccacagcc cacattttgc 541 tctgtctgcc acgagtttgt ctggggcctg aacaaacagg gctaccagtg ccgacaatgc 601 aatgcagcaa atcacaagaa gtgtattgat aaagttatag caaagtgcac aggatcagct 661 atcaatagcc gagaaaccat gttccacaag gagagattca aaattgacat gccacacaga 721 tttaaagtct acaattacaa gagcccgacc ttctgtgaac actgtgggac cctgctgtgg 781 ggactggcac ggcaaggact caagtgtgat gcatgtggca tgaatgtgca tcatagatgc 841 cagacaaagg tggccaacct ttgtggcata aaccagaagc taatggctga agcgctggcc 901 atgattgaga gcactcaaca ggctcgctgc ttaagagata ctgaacagat cttcagagaa 961 ggtccggttg aaattggtct cccatgctcc atcaaaaatg aagcaaggcc gccatgttta 1021 ccgacaccgg gaaaaagaga gcctcagggc atttcctggg agtctccgtt ggatgaggtg 1081 gataaaatgt gccatctcc agaacctgaa ctgaacaaag aaagaccatc tctgcagatt 1141 aaactaaaaa ttgaggattt tatcttgcac aaaatgttgg ggaaaggaag ttttggcaag 1201 gtcttcctgg cagaattcaa gaaaaccaat caatttttcg caataaaggc cttaaagaaa 1261 gaagtggtct tgatggacga tgatgttgag tgcacgatgg tagagaagag agttctttcc 1321 ttggcctggg agcatccgtt tctgacgcac atgttttgta cattccagac caaggaaaac 1381 ctcttttttg tgatggagta cctcaacgga ggggacttaa tgtaccacat ccaaagctgc 1441 cacaagttcg acctttccag agcgacgttt tatgctgctg aaatcattct tggtctgcag 1501 ttccttcatt ccaaaggaat agtctacagg gacctgaagc tagataacat cctgttagac 1561 aaagatggac acatcaagat cgcggatttt ggaatgtgca aggagaacat gttaggagat 1621 gccaagacga ataccttctg tgggacacct gactacatcg ccccagagat cttgctgggt 1681 cagaaataca accactctgt ggactggtgg tccttcgggg ttctccttta tgaaatgctg 1741 attggtcagt cgcctttcca cgggcaggat gaggaggagc tcttccactc catccgcatg 1801 gacaatccct tttacccacg gtggctggag aaggaagcaa aggaccttct ggtgaagctc WO 00/09525 1324 PCT/US99/17712 1861 ttcgtgcgag aacctgagaa gaggctgggc gtgaggggag acatccgcca gcaccctttg 1921 tttcgggaga tcaactggga ggaacttgaa cggaaggaga ttgacccacc gttccggccg 1981 aaagtgaaat caccatttga ctgcagcaat ttcgacaaag aattcttaaa cgagaagccc 2041 cggctgtcat ttgccgacag agcactgatc aacagcatgg accagaatat gttcaggaac 2101 ttttccttca tgaaccccgg gatggagcgg ctgatatcct gaatcttgcc cctccagaga 2161 caggaaagaa tttgccttct ccctgggaac tggttcaaga gacactgctt gggttccttt 2221 ttcaacttgg aaaaagaaag aaacactcaa caataaagac tgagacccgt tcgcccccat 2281 gtgactttat ctgtagcaga aaccaagtct acttcactaa tgacgatgcc gtgtgtctcg 2341 tctcctgaca tgtctcacag acgctcctga agttaggtca ttactaacca tagttattta 2401 cttgaaagat gggtctccgc acttggaaag gtttcaagac ttgatactgc aataaattat 2461 ggctcttcac ctgggcgcca actgctgatc aacgaaatgc ttgttgaatc aggggcaaac 2521 ggagtacaga cgtctcaaga ctgaaacggc cccattgcct ggtctagtag cggatctcac 2581 tcagccgcag acaagtaatc actaacccgt tttattctat cctatctgtg gatgtataaa 2641 tgctgggggc cagccctgga taggttttta tgggaattct ttacaataaa catagcttgt 2701 acttg 1 atgcccagca ggaccgaccc caagatggaa gggagcggcg gccgcgtccg cctcaaggcg 61 cattacgggg gggacatctt catcaccagc gtggacgccg ccacgacctt cgaggagctc 121 tgtgaggaag tgagagacat gtgtcgtctg caccagcagc acccgctcac cctcaagtgg 181 gtggacagcg aaggtgaccc ttgcacggtg tcctcccaga tggagctgga agaggctttc 241 cgcctggccc gtcagtgcag ggatgaaggc ctcatcattc atgttttccc gagcacccct 301 gagcagcctg gcctgccatg tccgggagaa gacaaatcta tctaccgccg gggagccaga 361 agatggagga agctgtaccg tgccaacggc cacctcttcc aagccaagcg ctttaacagg 421 agagcgtact gcggtcagtg cagcgagagg atatggggcc tcgcgaggca aggctacagg 481 tgcatcaact gcaaactgct qgtccataag cgctgccacg gcctcgtccc gctgacctgc 541 aggaagcata tggattctgt catgccttcc caagagcctc cagtagacga caagaacgag 601 gacgccgacc ttccttccga ggagacagat ggaattgctt acatttcctc atcccggaag 661 catgacagca ttaaagacga ctcggaggac cttaagccag ttatcgatgg gatggatgga 721 atcaaaatct ctcaggggct tgggctgcag gactttgacc taatcagagt catcgggcgc 781 gggacgtacg ccaaggttct cctggtgcgg ttgaagaaga atgaccaaat ttacgccatg 841 aaagtggtga agaaagagct ggtgcatgat gacgaggata ttgactgggt acagacagag 901 aagcacgtgt ttgagcaggc atccagcaac cccttcctgg tcggattaca ctcctgcttc 961 cagacgacaa gtcggttgtt cctggtcatt gagtacgtca acggcgggga cctgatgttc 1021 cacatgcaga ggcagaggaa gctccctgag gagcacgcca ggttctacgc ggccgagatc 1081 tgcatcgccc tcaacttcct gcacgagagg gggatcatct acagggacct gaagctggac 1141 aacgtcctcc tggatgcgga cggacacatc aagctcacag actacggcat gtgcaaggaa 1201 ggcctgggcc ctggtgacac aacgagcact ttctgcggaa ccccgaatta catcgccccc 1261 gaaatcctgc ggggagagga gtacgggttc agcgtggact ggtgggcgct gggagtcctc 1321 atgtttgaga tgatggccgg gcgctccccg ttcgacatca tcaccgacaa cccggacatg 1381 aacacagagg actacctttt ccaagtgatc ctggagaagc ccatccggat cccccggttc 1441 ctgtccgtca aagcctccca tgttttaaaa ggatttttaa ataaggaccc caaagagagg 1501 ctcggctgcc ggccacagac tggattttct gacatcaagt cccacgcgtt cttccgcagc 1561 atagactggg acttgctgga gaagaagcag gcgctccctc cattccagcc acagatcaca 1621 gacgactacg gtctggacaa ctttgacaca cagttcacca gcgagcccgt gcagctgacc 1681 ccagacgatg aggatgccat aaagaggatc gaccagtcag agttcgaagg ctttgagtat 1741 atcaacccat tattgctgtc caccgaggag tcggtgtga 1 tgtcatgcct tcccaagagc ctccaggatg gctgtcctcc gacctcctcc acctccaggc 61 tctagatggc aaagcccact tagcaaaagc cacctgctct gtgatgatgg gactggctcc 121 tgcctgtggg ttcggaaagc ccatcccacc ctctacagcc tcttgctcct ctgcaatgac 181 tgtgccttca cctgggggtt ccccagagac tagtgagagt catcgggcgt ggaagctat (2) INFORMATION FOR SEQ ID NO:177: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1649 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (0) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:177: gccacttctt ctgggcccac gaggcagctg tcccatgctc tgctgagcac ggtggtgcca 61 tgcctctgca actcctcctg ttgctgatcc tactgggccc tggcaacagc ttgcagctgt 121 'gggacaccg ggcagatgaa gccgagaaag ccttgggtcc cctgcttgcc cgggaccgga 181 gacaggccac cgaatatgag tacctagatt atgatttcct gccagaaacg gagcctccag 241 aaatgctgag gaacagcact gacaccactc ctctgactgg gcctggaacc cctgagtcta 301 ccactgtgga gcctgctgca aggcgtgcta ctggcctgga tgcaggaggg gcagtcacag 361 agctgaccac ggagctggcc aacatgggga acctgtccac ggattcagca gctatggaga 421 tacagaccac tcaaccagca gccacggagg cacagaccac tccactggca gccacagagg 481 cacagacaac tcgactgacg gccacggagg cacagaccac tccactggca gccacagagg 541 cacagaccac tccaccagca gccacggaag cacagaccac tcaacccaca ggcctggagg 601 cacagaccac tgcaccagca gccatggagg cacagaccac tgcaccagca gccatggaag 661 cacagaccac tccaccagca gccatggagg cacagaccac tcaaaccaca gccatggagg WO 00/09525 t325 PCTUS99/17712 721 cacagaccac tgcaccagaa gccacggagg cacagaccac tcaacccaca gccacggagg 781 cacagaccac tccactggca gccatggagg ccctgtccac agaacccagt Qccacagagg 841 ccctgtccat ggaacctact accaaaagag guctattcat acccttttct gtgtcctctg 901 ttactcacaa gggcattccc arggcagcca gcaatttgtc cgtcaactac ccagtggggg 961 coccagacca catctctgtg aagcagtgcc tgctggccat cctaatcttg gcgctggtgg 1021 ccactatctt cttcgtgtgc actgtggtgc tggcggtccg cctctcccgc aagggccaca 1081 tgtaccccgt gcgtaattac tcccccaccg agatggtctg catctcatcc ctgttgcctg 1141 atgggggtga ggggccctct gccacagcca atgggggcct gtccaaggcc aagagcccgg 1201 gcctgacgcc agagcccagg gaggaccgtg agggggatga cctcaccctg cacagcttcc 1261 tcccttagct cactctgcca tctgttttgg caagacccca cctccacggg ctctcctggg 1321 ccacccctga gtgcccagac cccaatccac agctctgggc ttcctcggag acccctgggg 1381 atggggatct tcagggaagg aactctggcc acccaaacag gacaagagca gcctggggcc 1441 aagcagacgg gcaagtggag ccacctcttt cctccctccg cggatgaagc ccagccacat 1501 ttcagccgag gtccaaggca ggaggccatt tacttgagac agattctctc ctttttcctg 1561 tcccccatct tctctgggtc cctctaacat ctcccatggc tctccccgct tctcctggtc 1621 actggagtct cctccccatg tacccaagg (2) INFORMATION FOR SEQ ID NO:178: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 703 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:178: 1 ccaccaatct tgggcaagaa gcgagaccat tctccttttt ctctggtcac tcctgtcctt 61 cagggggctc cctctggccc cgactgtcca ttgctgctga agtaatgctg tggcctttct 121 cagtttgggc cccacccaaa accgaagaac ttctccccag aagcttctac ttggttctca 181 gtgttttcac agttatggga acccaagaac aatgtcaaac ctaggaggtg ccccactacc 241 accctgtctt tatcaatgtt gtcaccaaag ctgtcacaaa caatggggtg tgggctgtca 301 catggccctg cctaagtaac cacattctcg cttcctcctt ccacacacag ccattggggg 361 ttgctcggat ccgggactgc cgcagggggt gccacagcag tgcctggcag cgtgggctgg 421 gaccttgtca ctaaagcaga gaagccactt cttctgggcc cacgaggcag ctgtcccatg 481 ctctgctgag cacggtggta agtgctggct tgcaaaacca cagggagtgg ctggaggtcc 541 ccatgggcca agggcctgcc ttatagctgc tggcaggccc gggtaggacc gccaggccct 601 tcttgagctg cagcacctgg ggagggcaaa ctgaggctcc tccgactcaa gactaaagtc 661 ttcctggagt ctgtggcctt attctgtgac tcttctgaat cct (2) INFORMATION FOR SEQ ID NO:179: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 3409 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:179: 1 tagaagaagt taaagggccc tcctggatgg ctttattcat gttgatgagt aataataata 61 actgctactq gctgaggatc tccrccatcc caggcatgrc agggatgcct aagtccccaa 121 tccctgctcc agaccagaca crccagcr gtggcagtag agggtggtgg tctagggtgc 181 ttgctaagcc caagggtgaa actgtcttga catccctccg cccattgtct cctcctaggt 241 gccatgcctc tgcaactcct cctgttgctg atcctactgg gccctggcaa cagcttgcag 301 ctgtgggaca cctgggcaga tgaagccgag aaagccttgg gtcccctgct tgcccgggac 361 cggagacagg ccaccgaata tgagtaccra gattatgatt tcctgccaga aacggagcct 421 ccagaaatgc tgaggaacag cactgacacc acccctga ctgggcctgg aacccctgag 481 tctaccactg tggagcctgc tgcaaggcgt tctactggcc tggatgcagg aggggcagtc 541 acagagctga ccacggagct ggccaacatg gggaacctgt ccacggattc agcagctatg 601 gagatacaga ccactcaacc agcagccacg gaggcacaga ccactcaacc agtgcccacg 661 gaggcacaga ccactccact ggcagccaca gaggcacaga caactcgact gacggccacg 721 gaggcacaga ccactccact ggcagccaca gaggcacaga ccactccacc agcagccacg 781 gaagcacaga ccactcaacc cacaggcctg gaggcacaga ccactgcacc agcagccatg 841 gaggcacaga ccactgcacc agcagccatg gaagcacaga ccactccacc agcagccatg 901 gaggcacaga ccactcaaac cacagccatg gaggcacaga ccactgcacc agaagccacg 961 gaggcacaga ccactcaacc cacagccacg gaggcacaga ccactccact ggcagccatg 1021 gaggccctgt ccacagaacc cagtgccaca gaggccctgt ccatggaacc tactaccaaa 1081 agaggtctgt tcataccctt ttctgtgtcc tctgttacrc acaagggcat tcccatggca 1141 gccagcaatt tgtccgtcaa ctacccagrg ggggccccag accacatctc tgtgaagcag 1201 tgcctgctgg ccatcctaat cttggcgctg gtggccacta tcttcttcgt gcgcactgtg 1261 gtgctggcgg tccgcctctc ccgcaagggc cacatgtacc ccgtgcgtaa ttactccccc 1321 accgagatgg tctgcatctc atccctgttg cctgatgggg gtgaggggcc ctctgccaca 1381 gccaatgggg gcctgtccaa ggccaagagc ccgggcctga cgccagagcc cagggaggac 1441 cgtgaggggg atgacctcac cctgcacagc ttcctccctr agctcactct gccatctgtt 1501 ttggcaagac cccacctcca cgggctctcc tgggccaccc ctgagtgccc agaccccaat 1561 ccacagctct gggcttcctc qgagacccct ggggatgggg atcttcaggg aaggaactct 1621 ggccacccaa acaggacaag agcagcctaa ggccaagcag acgggcaagt ggagccacct 1681 ctccccc accacggacg aagcccagcc acatttcaac cgaggtccaa ggcaggaggc WO 00/09525 1326 PCTIUS99/17712 1741 catttacttg aaacagattc tctccttr cctgtccccc accctg ggtccctcta 1801 acatctccca tggctctccc cqcttctcct ggtcactgga gcccctccc catgtaccca 1861 aggaagatgg agctccccca tcccacaccc actgcactgc cattgtcttt tggttgccaL 1921 ggtcaccaaa caggaagtgg acattctaag ggaggagtac tgaagagtga cggacttctg 1981 aggctgtttc ctgctgctcc tctgacttgg ggcagcccgg gtcttcttgg gcaccccct 2041 gggaaaaccc agggtgaggt tcagcctgtg agggctggga tgggtttcgt gggcccaaag 2101 ggcagacctt tctttgggac tgtgtggacc aaggagcttc catctagtga caagtgaccc 2161 ccagctatcg cctcttacct ccccgtgg ccactttcca gggtggactc tgtcttgttc 2221 actgcagtat cccaacrgca ggtccagtac aggcaataaa tatgtgatgg acaaaacgat 2281 agcggaatcc ttcaaggtc caaggctgrc tccttcaggc agccttcccg gaattctcca 2341 tccctcagtg caggatgggg gctgatcctc agctgtctgc cctcagcccc tggcccccca 2401 ggaagcccc ttcatgggct gttaggttga cttcagtttt gcctcttgga caacaggggg 2461 tcttgtacat ccttgggtga ccaggaaaag ttcaggctat ggggggccaa agggagggct 2521 gccccttccc caccagtgac cactttattc cacttcctcc attacccagt tttggcccac 2581 agagtttggt cccccccaaa cctcggacca atatccctct aaacatcaat ctatcctcct 2641 gttaaagaaa aaaaaaaatg ggactgggag cagtggctca tgcctgtaat cccagcactt 2701 tgggaggccg aggcaggtac atcacctgag gtcaggagtt caagactagc ctggccaaca 2761 tagtgaaacc ctgtctctac taaaaataca aagattagtc aggtgtggtg gcacatgcct 2821 gtagtcccag ctactgggga ggctgaggca ggagaattgc ttgaacccgg gaagcggagg 2881 gaggttgcag tgagctgaga tcacgctact gcactccagc ctgggtgaca gagtaagact 2941 ccgtctcaaa aaaaaaaaaa aagattcaat gacccttgtt aaagcatggt aaggaagact 3001 ttgttcaagg ggagtgggac tctctcaatc actgcaggga ctgcagctat gggattttgc 3061 agtgggggca tttgggctca actatgagta cagcaggggc aagtgggagc tgatagccag 3121 ggaacagggt tggatatctg cagctggaaa attaccaaga ggaaacatca ggggaagggg 3181 aattctggct aaactgactg ctggggatgg gttctcggtc attttctaca ctgacctaac 3241 aggattcata ctggaggcag gccagggtgc tcagacatca ccggggggat ggtggcagat 3301 gaggaacgtg agcagatata ggaggtgatc agatatggga ggtgatcaga atggagtgg 3361 tggggggagg gggttgcta actgacta gcagagttct tgttagaac (2) INFORMATION FOR SEQ ID NO:180: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 3409 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:180: 1 tagaagaagt taaagggccc tcctggatgg ctttattcat gttgatgagt aataataata 61 actgcactg gcctaggatc ttctccatcc caggcatgtc agggatgcct aaatccccag 121 tccctgctcc agaccagaca tctccagct gggcagtag agggtggtgg ctagggtgc 181 ttgctaagcc caagggtgaa actgccttga catccctccg cccattgtct cctcctaggt 241 gccatgcctc tgcaactcct cctgttgctg atcctactgg gccctggcaa cagcttgcag 301 ctgtgggaca cctgggcaga tgaagccgag aaagccttgg gtcccctgct tgcccgggac 361 cggagacagg ccaccgaata tgagtaccta gattatgatt tcctgccaga aacggagcct 421 ccagaaatgc tgaggaacag cactgacacc actcctctga ctgggcctgg aacccctgag 481 tctaccactg aggagcctgc tgcaaggcgt tctactggcc tggatgcagg aggggcagtc 541 acagagctga ccacggagct ggccaacatg gggaacctgt ccacggattc agcagctata 601 gagatacaga ccactcaacc agcagccacg gaggcacaga ccactcaacc agtgcccacg 661 gaggcacaga ccactccact ggcagccaca gaggcacaga caactcgact gacggccacg 721 gaggcacaga ccacccact ggcagccaca gaggcacaga ccactccacc agcagccacg 781 gaagcacaga ccactcaacc cacaggcctg gaggcacaga ccactgcacc agcagccatg 841 gaggcacaga ccactgcacc agcagccatg gaagcacaga ccactccacc agcagccatg 901 gaggcacaga ccactcaaac cacagccatg gaggcacaga ccactgcacc agaagccacg 961 gaggcacaga ccactcaacc cacagccacg gaggcacaga ccactccact ggcagccatg 1021 gaggccctgt ccacagaacc cagtgccaca gaggccctgt ccatggaacc tactaccaaa 1081 agaggtctgt cataccctt ttctgtgtcc tctgttactc acaagggcat tcccatggca 1141 gccagcaatt tgtccgtcaa ctacccagtg ggggccccag accacatctc tgtgaagcag 1201 tgcctgctgg ccatcctaat cttggcgctg gtggccacta tcttcttcgt gtgcactgtg 1261 gtgctggcgg tccgcctctc ccgcaagggc cacatgtacc ccgtgcgtaa ttactccccc 1321 accgagatgg tctgcaactc atccctgttg cctgatgggg ggaggggcc ctcgccaca 1381 gccaatgggg gcctgtccaa ggccaagagc ccgggcctga cgccagagcc cagggaggac 1441 cgtgaggggg atgaccccac cctgcacagc ttcctccctt agctcactct gccatctgtt 1501 tggcaagac cccacctcca cgggctctcc tgggccaccc ctgagtgccc agaccccaat 1561 ccacagctct gggcttcctc ggagacccct ggggatgggg atcttcaggg aaggaactct 1621 ggccacccaa acaggacaag agcagcctgg ggccaagcag acgggcaagt ggagccacct 1681 ctttcctccc tccgcggatg aagcccagcc acatttcagc cgaggccaa ggcaggaggc 1741 catttacttg agacagattc tctccttttt cctgtccccc atcttctctg ggtccctcta 1801 acatctccca tggctctccc cgcttctcc c ggtcactgga gtctcctccc catgtaccca 1861 aggaagatgg agcgccccca tcccacacgc actgcactgc cattgtcttt tggttgccat 1921 ggtcaccaaa caggaagtgg acactaag ggaggagtac tgaagagtga cggacttctg 1981 aggctgtttc ctgcucgccc tcgactgg ggcagcttgg gtcttcttgg gcacctctct 2041 gggaaaaccc agggtgaggt tcagcctatg agggctggga tgggttcgt gggcccaaag WO 00/09525 1327 PCT/US99/17712 2101 ggcagacctt tctgggac tqtgtggacc aaggagcttc catctagtga caagtgaccc 2161 ccagctatcg cctcttgcct tcccctgtgg ccactttcca gggtggactc tgtcttgttc 2221 actgcagtat cccaactgca ggtccagtgc aggcaataaa tatgtgatgg acaaaacgat 2281 agcggaatcc ttcaaggttt caaggctgtc ccccaggc agccttcccg gaattctcca 2341 tccctcaatg caggatgggg gctggtcctc agctgtctgc cctcagcccc tggcccccca 2401 ggaagcctct ttcatgggct gttaggttga cttcagtttt gcctcttgga caacaggggg 2461 tcttgtacat ccttgggtga ccaggaaaag ttcaggctat ggggggccaa agggagggct 2521 gcccccttccc caccagtgac cactttattc cacttcctcc attacccagt tttggcccac 2581 agagtttggt cccccccaaa cctcggacca atatccctct aaacatcaat ctatcctcct 2641 gttaaagaaa aaaaaaaatg ggactgggag cagtggctca tgcctgtaat cccagcactt 2701 tgggaggccg aggcaggtac atcacctgag gtcaggagtt caagactagc ctggccaaca 2761 tagtgaaacc ctgtccctac taaaaataca aagattagtc aggtgtggtg gcacatgcct 2821 gtagtcccag ctactgggga ggctgaggca ggagaattgc ttgaacccgg gaagcggagg 2881 gaggttgcag tgagctgaga tcacgctact gcactccagc ctgggtgaca gagtaagact 2941 ccgtctcaaa aaaaaaaaaa aagattcaat gacccttgtt aaagcatggt aaggaagact 3001 ttgttcaagg ggagtgggac ccctcaatc actgcaggga ctgcagctat gggattttgc 3061 agtgggggca tttgggctca actatgagta cagcaggggc aagtgggagc tgatagccag 3121 ggaacagggt tggatatctg cagctggaaa attaccaaga ggaaacatca ggggaagggg 3181 aattctggct aaactgactg ctggggatgg gttctcggtc attttctaca ctgacctaac 3241 aggattcata ctggaggcag gccagggtgc tcagacatca ccggggggat ggtggcagat 3301 gaggaacgtg atcagatata ggaggtgatc agatatggga ggtgatcaga tatggagtgg 3361 tggggggagg gttgttgcta agctgactta gcagagttct gttagaac (2) INFORMATION FOR SEQ ID NO:181: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 9170 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:181: 1 gccacttctt ctgggcccac gaggcagctg tcccatgctc tgctgagcac ggtggtgcca 61 tgcctctgca actcctcctg ttgctgatcc tactgggccc tggcaacagc ttgcagctgt 121 gggacacctg ggcagatgaa gccgagaaag ccttgggtcc cctgcttgcc cgggaccgga 181 gacaggccac cgaaatgag tacctagatt atgatttcct gccagaaacg gagcctccag 241 aaatgctgag gaacagcact gacaccact ctctgactgg gcctggaacc cctgagtcta 301 ccactgtgga gcctgctgca aggcgttca ctggcctgga tgcaggaggg gcagtcacag 361 agctgaccac ggagctggcc aacatgggga acctgtccac ggattcagca gctatggaga 421 tacagaccac tcaaccagca gccacggagg cacagaccac tccactggca gccacagagg 481 cacagacaac tcgactgacg gccacggagg cacagaccac tccactggca gccacagagg 541 cacagaccac tccaccagca gccacggaag cacagaccac tcaacccaca ggcctggagg 601 cacagaccac tgcaccagca gccatggagg cacagaccac tgcaccagca gccatggaag 661 cacagaccac tccaccagca gccatggagg cacagaccac tcaaaccaca gccatggagg 721 cacagaccac tgcaccagaa gccacggagg cacagaccac tcaacccaca gccacggagg 781 cacagaccac tccactggca gccatggagg ccctgtccac agaacccagt gccacagagg 841 ccctgtccat ggaacctcac accaaaagag gtctgttcat acccttttct gtgtcctctg 901 ttactcacaa gggcattccc atggcagcca acaatttgtc cgtcaactac ccagggggg 961 ccccagacca catctctgtg aagcagtgcc tgctggccat cctaatcttg gcgctggtgg 1021 ccactaactt cttcggggc actgtggtgc tggcggtccg cctctcccgc aagggccaca 1081 tgtaccccgt gcgtaattac tcccccaccg agatggtctg catctcatcc ctgttgcctg 1141 atgggggtga ggggccctc gccacagcca atgggggcct gtccaaggcc aagagcccgg 1201 gcctgacgcc agagcccagg gaggaccgtg agggggatga cctcaccctg cacagcttcc 1261 tcccttagct cactctgcca tctgttttgg caagacccca cctccacggg ctctcctggg 1321 ccacccctga gtgcccagac cccaatccac agctctgggc ttcctcggag acccctgggg 1381 atggggatct tcagggaagg aactctggcc acccaaacag gacaagagca gcctggggcc 1441 aagcagacgg gcaagtggag ccacctcttt cctccctccg cggatgaagc ccagccacat 1501 ttcagccgag gtccaaggca ggaggccatt tacttgagac agattctctc ctttttcctg 1561 tcccccatct tctctgggtc cctctaacat ctcccatggc tctccccgct tctcctggtc 1621 actggagcct cctccccatg tacccaagg 1 ccaccaatct tgggcaagaa gcgagaccat tctcctttat ctctggtcac tcctgtcctt 61 cagggggctc cctctggccc cgactgtcca ttgctgctga agtaatgctg tggcctttct 121 cagtttgggc cccacccaaa accgaagaac ttctccccag aagcttctac ttggttctca 181 gtgttttcac agttatggga acccaagaac agtgtcagac ctaggaggtg ccccactacc 241 accctgtctt tatcaatgtt gtcaccaaag ctgtcacaaa caatggggtg tgggctgtca 301 catggccctg cctaagtaac cacattctcg cttcctcctt ccacacacag ccattggggg 361 ttgctcggat ccgggactgc cocagggggt gccacagcag tgcctggcag cgtgggctgg 421 gaccttgtca ctaaagcaga gaagccactt cttctgggcc cacgaggcag ctgtcccatg 481 ctctgctgag cacggtggta agtgctggct tgcaaaacca cagggagtgg ctggaggtcc 541 ccatgggcca agggcctgcc ttatagctgc tggcaggccc gggtaggacc gccaggccct 601 tcctgagctg cagcaccagg ggagggcaaa ctgaggctcc tccgactcaa gactaaagtc 661 ttcctggagt ctgtggcctt actctgtgac tcttctgaat cct 1 tagaagaagr taaagggccc tcctagatgg ctttattcat gtcatgagt aataataata 61 actgctactg gctoaggarc trcccatcc caggcatgtc agggatgcct aagtccccag 121 tccctacrcc agaccagaca actccagct gggcagtag agggtggtgg ctagggtgc WO 00/09525 1328 PCT/US99/17712 181 ttgctaaacc caagggtgaa actgtcttga catccctccg cccattgtct cctcctaggt 241 gccatgccrc tgcaactcct cctgttgctg atIcctactgg gccctggcaa cagcttgcag 301 ctgtgggaca cctgggcaga tgaagccgag aaagcctrgg gtcccctgct tgcccgggac 361 cggagacagg ccaccgaata rgagtaccta gattatuatt tcctgccaga aacggagcct 421 ccagaaatgc tgaggaacaq cactgacacc actcctctga ctgggcctgg aacccctgag 481 tctaccactg tggagcctgc tgcaaggcgt tctactggcc tggatgcagg aggggcagtc 541 acagagctga ccacggagct ggccaacatg gggaacctgt ccacggattc agcagctatg 601 gagatacaga ccactcaacc agcagccacg gaggcacaga ccactcaacc agtgcccacg 661 gaggcacaga ccactccact ggcagccaca gaggcacaga caactcgact gacggccacg 721 gaggcacaga ccactccact ggcagccaca gaggcacaga ccactccacc agcagccacg 781 gaagcacaga ccactcaacc cacaggcctg gaggcacaga ccactgcacc agcagccatq 841 gaggcacaga ccactgcacc agcagccatg gaagcacaga ccactccacc agcagccatg 901 gaggcacaga ccactcaaac cacagccatg gaggcacaga ccactgcacc agaagccacg 961 gaggcacaga ccactcaacc cacagccacg gaggcacaga ccactccact ggcagccatg 1021 gaggccctgt ccacagaacc cagtgccaca gaggccctgt ccatggaacc tactaccaaa 1081 agaggtctgt tcataccctt ttctgtgtcc tctgttactc acaagggcat tcccatggca 1141 gccagcaatt tgtccgtcaa ctacccagtg ggggccccag accacatctc tgtgaagcag 1201 tgcctgctgg ccatcctaat cttggcgctg gtggccacta tcttcttcgt gtgcactgtg 1261 gtgctggcgg tccgcctctc ccgcaagggc cacatgtacc ccgtgcgtaa ttactccccc 1321 accgagatgg tctgcatctc atccctgttg cctgatgggg gtgaggggcc ctctgccaca 1381 gccaatgggg gcctgtccaa ggccaagagc ccgggcctga cgccagagcc cagggaggac 1441 cgtgaggggg atgacctcac cctgcacagc ttcctccctt agctcactct gccatctgtt 1501 ttggcaagac cccacctcca cgggctctcc tgggccaccc ctgagtgccc agaccccaat 1561 ccacagctct gggcttcctc ggagacccct ggggatgggg atcttcaggg aaggaactct 1621 ggccacccaa acaggacaag agcagcctgg ggccaagcag acgggcaagt ggagccacct 1681 ctttcctccc tccgcggatg aagcccagcc acatttcagc cgaggtccaa ggcaggaggc 1741 catttacttg agacagattc tctccttttt cctgtccccc atcttctctg ggtccctcta 1801 acatctccca tggctctccc cgcttcccc ggtcactgga gtctcctccc catgtaccca 1861 aggaagatgg agctccecca tcccacacgc actgcactgc cattgtcttt tggttgccat 1921 ggtcaccaaa caggaagtgg acattctaag ggaggagtac tgaagagtga cggacttctg 1981 aggctgtttc ctgctgctcc tctgacttgg ggcagcttgg gtcttcttgg gcacctctct 2041 gggaaaaccc aggqtgaggt tcagcctgtg agggctggga tgggtttcgt gggcccaaag 2101 ggcagacctt tctttgggac tgtgtggacc aaggagcttc catctagtga caagtgaccc 2161 ccagctatcg cctcttgcct tcccctgtgg ccactttcca gggtggactc tgtcttgttc 2221 actgcagtat cccaactgca ggtccagtgc aggcaataaa tatgtgatgg acaaaacgat 2281 agcggaatcc ttcaaggttt caaggctgtc tccttcaggc agccttcccg gaattctcca 2341 tccctcagtg caggatgggg gctggtcctc agctgtctgc cctcagcccc tggcccccca 2401 ggaagcctct ttcatgggct gttaggttga cttcagtttt gcctcttgga caacaggggg 2461 tcttgtacat ccttgggtga ccaggaaaag ttcaggctat ggggggccaa agggagggct 2521 gccccttccc caccagtgac cactttattc cacttcctcc attacccagt tttggcccac 2581 agagtttggt cccccccaaa cctcggacca atatccctct aaacatcaat ctatcctcct 2641 gttaaagaaa aaaaaaaatg ggactgggag cagtggctca tgcctgtaat cccagcactt 2701 tgggaggccg aggcaggtac atcacctgag gtcaggagtt caagactagc ctggccaaca 2761 tagtgaaacc ctgtctctac taaaaataca aagattagtc aggtgtggtg gcacatgcct 2821 gtagtcccag ctactgggga ggctgaggca ggagaattgc ttgaacccgg gaagcggagg 2881 gaggttgcag tgagctgaga tcacgctact gcactccagc ctgggtgaca gagtaagact 2941 ccgtctcaaa aaaaaaaaaa aagattcaat gacccttgtt aaagcatggt aaggaagact 3001 ttgttcaagg ggagtgggac tctctcaatc actgcaggga ctgcagctat gggatttgac 3061 agtgggggca tttgggctca actatgagta cagcaggggc aagtgggagc tgatagccag 3121 ggaacagggt tggatatctg cagctggaaa attaccaaga ggaaacatca ggggaagggg 3181 aatctggct aaactgactg ctggggatgg gttctcggtc attttctaca ctgacctaac 3241 aggattcata ctggaggcag gccagggtgc tcagacatca ccggggggat ggtggcagat 3301 gaggaacgtg atcagatata ggaggtgatc agatatggga ggtgatcaga tatggagtgg 3361 tggggggagg gttgttgcta agctgactta gcagagttct tgttagaac 1 tagaagaagt taaagggccc tcctggatgg ctttattcat gttgatgagt aataataata 61 actgctactg gctgaggatc ttctccatcc caggcatqtc agggatgcct aagtccccag 121 tccctgctcc agaccagaca tcttccagct gtggcagtag agggtggtgg tctagggtgc 181 tcgctaagcc caagggtgaa actgtcttga catccctccg cccattgtct cctcctaggt 241 gccatgcctc tgcaactcct cctgttgctg atcctactgg gccctggcaa cagcttgcag 301 ctgtgggaca cctgggcaga tgaagccgag aaagccttgg gtcccctgct tgcccgggac 361 cggagacagg ccaccgaata tgagtaccta gattatgatt tcctgccaga aacggagcct 421 ccagaaatgc tgaggaacag cactgacacc actcctctga ctgggcctgg aacccctgag 481 tctaccactg tggagcctgc tgcaaggcgt tctactggcc tggatgcagg aggggcagtc 541 acagagctga ccacggagct ggccaacatg gggaacctgt ccacggattc agcagctatg 601 gagatacaga ccactcaacc agcagccacg gaggcacaga ccactcaacc agtgcccacg 661 gaggcacaga ccactccact ggcagccaca gaggcacaga caactcgact gacggccacg 721 gaggcacaga ccactccact ggcagccaca gaggcacaga ccactccacc agcagccacg 781 gaagcacaga ccactcaacc cacaggcctq gaggcacaga ccactgcacc agcagccatg 841 gaggcacaga ccactgcacc agcagccatg gaagcacaga ccactccacc agcagccatg 901 gaggcacaga ccactcaaac cacagccatg gaggcacaga ccactgcacc agaagccacg 961 gaggcacaga ccactcaacc cacagccacg gaggcacaga ccactccact ggcagccatg 1021 gaggccctgt ccacagaacc cagtgccaca gaggccctgt ccatggaacc tactaccaaa 1081 agaggtctgt tcacaccctt ttctgtgtcc tctgttactc acaagggcat tcccatggca 1141 gccagcaatt tgtccgtcaa ctacccagtg ggggccccag accacatctc tgtgaagcag 1201 tgcctgctgg ccatcccaat cttggcgcrg gtggccacta tcttcttcgt gtgcactgtg WO 00/09525 1329 PCT/US99/17712 1261 gtgctggcgg tccacctctc ccgcaagggc cacatgtacc ccgtgcgtaa ttactccccc 1321 accgagatgg tctgcatctc atccctgttg cctgatgggg gtgaggggcc ctctgccaca 1381 gccaatgggg gcctgtccaa ggccaagagc ccgggcctua cgccagagcc cagggaggac 1441 cgtgaggggg atgacctcac cctgcacagc ttcctccctt agctcactct gccatctgtt 1501 ttggcaagac cccacctcca cgggctctcc tgggccaccc ctgagtgccc agaccccaat 1561 ccacagctct gggcttcctc ggagacccct ggggatgggg atcttcaggg aaggaactct 1621 ggccacccaa acaggacaag agcagcctgg ggccaagcag acgggcaagt ggagccacct 1681 ctttcctccc tccgcggatg aagcccagcc acatttcagc cgaggtccaa ggcaggaggc 1741 catttacttg agacagattc tcccttttt cctgtccccc atcttctctg ggtccctcta 1801 acatctccca tggctctccc cgcttctcct ggtcactgga gtctcctccc catgtaccca 1861 aggaagatgg agctccccca tcccacacgc actgcactgc cattgtcttt tggttgccat 1921 ggtcaccaaa caggaagtgg acattctaag ggaggagtac tgaagagtga cggacttctg 1981 aggctgtttc ctgctgctcc tctgacttgg ggcagcttgg gtcttcttgg gcacctctct 2041 gggaaaaccc agggtgaggt tcagcctgtg agggctggga tgggtttcgt gggcccaaag 2101 ggcagacctt tctttgggac tgtgtggacc aaggagcttc catctagtga caagtgaccc 2161 ccagctatcg cctcttgcct tcccctgtgg ccactttcca gggtggactc tgtcttgttc 2221 actgcagtat cccaactgca ggtccagtgc aggcaataaa tatgtgatgg acaaaacgat 2281 agcggaatcc ttcaaggttt caaggctgtc tccttcaggc agccttcccg gaattctcca 2341 tccctcagtg caggatgggg gctggtcctc agctgtctgc cctcagcccc tggcccccca 2401 ggaagcctct ttcatgggct gttaggttga cttcagtttt gcctcttgga caacaggggg 2461 tcttgtacat ccttgggtga ccaggaaaag ttcaggctat ggggggccaa agggagggct 2521 gccccttccc caccagtgac cactttattc cacttcctcc attacccagt tttggcccac 2581 agagtttggt cccccccaaa cctcggacca atatccctct aaacatcaat ctatcctcct 2641 gttaaagaaa aaaaaaaatg ggactgggag cagtggctca tgcctgtaat cccagcactt 2701 tgggaggccg aggcaggtac atcacctgag gtcaggagtt caagactagc ctggccaaca 2761 tagtgaaacc ctgtctctac taaaaataca aagattagtc aggtgtggtg gcacatgcct 2821 gtagtcccag ctactgggga ggctgaggca ggagaattgc ttgaacccgg gaagcggagg 2881 gaggttgcag tgagctgaga tcacgctact gcactccagc ctgggtgaca gagtaagact 2941 ccgtctcaaa aaaaaaaaaa aagattcaat gacccttgtt aaagcatggt aaggaagact 3001 ttgttcaagg ggagtgggac tctctcaatc actgcaggga ctgcagctat gggattttgc 3061 agtgggggca tttgggctca actatgagta cagcaggggc aagtgggagc tgatagccag 3121 ggaacagggt tggatatctg cagctggaaa attaccaaga ggaaacatca ggggaagggg 3181 aattctggct aaactgactg ctggggatgg gttctcggtc attttctaca ctgacctaac 3241 aggacata ctggaggcag gccagggtgc tagacatca ccggggggat ggtggcagat 3301 gaggaacgtg atcagacata ggaggtgatc agatatggga ggtgatcaga tatggagtgg 3361 tggggggagg gttgttgcca agccgactta gcagagttct tgttagaac (2) INFORMATION FOR SEQ ID NO:182: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1830 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:182: 1 cctgcctgca cggcacagga gagcaaactt otacagacag accaaggctt ccatttgctg 61 ctgacacatg gaactgaggt gaaattgtgc tccatgattt tacagatttc ataacgttta 121 agagacggga ccaggcat caaaatgaaa gccctcatct ttgcagctgc tggcctcctg 181 cttctgttgc ccactttttg acagagtggc atggaaaatg atacaaacaa cttggcaaag 241 ccaaccttac ccattaagac ctttcgtgga gctcccccaa attcttttga agagttcccc 301 ttttctgcc tggaaggccg gacaggagcc acgattactg taaaaattaa gtgccctgaa 361 gaaagtgctt cacatctcca tgtgaaaaat gctaccatgg ggtacctgac cagctcctta 421 agtactaaac tgatacctgc catctacctc ctggtgtttg tagttggtgt cccggccaat 481 gctgtgaccc tgtggatgct tttcttcagg accagatcca tctgtaccac tgtattctac 541 accaacctgg ccattgcaga ttttcttttt tgtgttacat tgccctttaa gatagcttat 601 catctcaatg ggaacaactg ggtatttgga gaggtcctgt gccgggccac cacagtcatc 661 ttctatggca acatgtactg ctccattctg ctccttgcct gcatcagcat caaccgctac 721 ctggccacg tccatccttt cacctaccgg ggcctgccca agcacaccta tgccttggta 781 acatgtggac tggtgtgggc aacagttttc ttatatatgc tgccattttt catactgaag 841 caggaatatt atcttggca gccagacatc accacctgcc atgatgttca caacacttgc 901 gagtcctcat ccccttcca actctattac ttcatctcct tggcattctt tggattctta 961 attccatttg tgcttatcat ctactgcat gcagccatca tccggacact taatgcatac 1021 gatcatagat ggttgtggca tgttaaggcg agtctcctca tccttgtgat ttttaccatt 1081 tgctttagcc caagcaatat tattttatt attcaccatg ctaactacta ctacaacaac 1141 actgatggct tatattttat atatctcata gctttgtgcc tgggtagtct taatagttgc 1201 tagaccat tcctttactr tccatgtca aaaaccagaa atcactccac tgcttacctt 1261 acaaaatagt gaaatggatc tagagaacaa ggacagccat cacagagaac gtctgttttc 1321 aagaacaaca taagcatagt gcaaggagct ccatttccga gctcctaaga aatatgcttc 1381 aaaggtcaaa cattacaaaa gcattagtag tttgtttgtt tgtttttgag actgagtctc 1441 actttatcac ccagactggc gtgcagtggc actatcttgg ctcattgcaa cctctgcctc 1501 ccaggtcagc ctcccaagta gctgggatta caccaccatg cccagctact aaaaatactt 1561 ggatttcag tagagacggg gtttcaccaa gttgaccagg ctggtcttga actcctgacc 1621 tcaagcgatc ttccggcctc agcctcccaa agtgctggat tacaggcgtg agccacgag 1681 ccagccagca ttaccaattt ttaaaaacac tttatcagta ttttaaaaat gttaatgcag 1741 gagaaaagat atcacaacc tatggaaaat aacatttcca tttgccttat tgctacttca 1801 agctcttaa atcaccatct tccctatttc WO 00/09525 1330 PCT/US99/17712 (2) INFORMATION FOR SEQ ID NO:183: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1534 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:183: 1 tcatgtgggg gcgactgctc ctgtggcccc tggtgctggg gttcagcctg tctggcggca 61 cccagacccc cagcgtctac gacgagagcg ggagcaccgg aggtggtgat gacagcacgc 121 cctcaatcct gcctgccccc cgcggctacc caggccaagt ctgtgccaat gacagtgaca 181 ccctggagct cccggacagc tcacgggcac tgcttctggg ctgggtgccc accaggctgg 241 tgcccgccct ctatgggctg gtcctggtgg tggggctgcc ggccaatggg ctggcgctgt 301 gggtgctggc cacgcaggca cctcggctgc cctccaccat gctgctgatg aacctcgcga 361 ctgctgacct cctgctggcc ctggcgctgc ccccgcggat cgcctaccac ctgcgtggcc 421 agcgctggcc cttcggggag gccgcctgcc gcctggccac ggccgcactc tatggtcaca 481 tgtatggctc agtgctgctg ctggccgccg tcagcctgga tcgctacctg gccctggtgc 541 acccgctgcg ggcccgcgcc ctgcgtggcc ggcgcctggc ccttggactc tgcatggctg 601 cttggctcat ggcggccgcc ctggcactgc ccctgacact gcagcggcag accttccggc 661 tggcgcgctc cgatcgcgtg ctctgccatg acgcgctgcc cctggacgca caggcctccc 721 actggcaacc ggccttcacc tgcctggcgc tgttgggctg tttcctgccc ctgctggcca 781 tgctgctgtg ctacggggcc accctgcaca cgctggcggc cagcggccgg cgctacggcc 841 acgcgctgag gctgaccgca gtggtgctgg cctccgccgt ggccttcttc gtgcccagca 901 acctgctgct gctgctgcat tactcggacc cgagccccag cgcctggggc aacctctatg 961 gtgcctacgt gcccagcctg gcgctgagca ccctcaacag ctgcgtggat cccttcatct 1021 actactacgt gtcggccgag ttcagggaca aggtgcgggc agggctcttc caacggtcgc 1081 cgggggacac cgtggcctcc aaggcctctg cggaaggggg cagccggggc atgggcaccc 1141 actcctcttt gctccagtga cacaaagtgg ggaaggctgt actgggtcga acagggtccc 1201 ttcccccact tcacgtcctt cctgggacct cagaatgtga ccttatttgg aaatagggtt 1261 gttacaactg tcactagcag aggtcacttt ggagaagggt gggccttaca tccagtgtgg 1321 gtggtgtcct cataagataa ggagaggcca ggcctggtgg ctcacgcctg taatcccagc 1381 actttaagag gccaaggcgg atggatcact tgagcccagg agttcaacac cagcctgagc 1441 aacatggtaa aaccccatct ctaccaaaaa tacaaaaatt agctgggctt ggtggctggc 1501 gcctgtaatc ccagctactc angagactga ggca (2) INFORMATION FOR SEQ ID NO:184: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 3472 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:184: cgcacccggg 301 cccgcaggcc agaaccaaaa gcaacaaacg ccaccttaga tccccggtca tttcttctca 361 ggaaccccaa cgataaatat gaaccattc gggaggatga ggagaaaaac gaaagcgggt 421 taactgaata cagattagcc tccatcaata aaagcagtcc ccttcaaaaa caacttcctg 481 cattcatctc agaagatgcc cccggatact tgaccagctc ccggctgaca ctctttgtcc 541 catctgtgta caccggagcg tttgtagtca gcctcccact aaacatcatg gccaccgttg 601 tgttcatcct gaaaatgaag gtcaagaagc cggcggtggt gtacatgctg cacctggcca 661 cggcagatgc gctgtttgtg tctgtgctcc cctttaagat cagctattac ttttccggca 721 gtgattggca gtttgggtct gaattgtgtc gcttcgtcac tgcagcattt tactgtaaca 781 tgtacgcctc tatcttgctc atgacagtca taagcattga ccggtttctg gctgtggtgt 841 atcccatgca gtccctctcc tggcgtactc tgggaagggc ttccttcact cgtctggcca 901 tctgggcttt ggccatcaca ggggtagtgc ctctcgtcct caaggagcaa accatccagg 961 tgcccgggct caacatcact acctgtcatg atgtgctcaa tgaaaccctg ctcgaaggct 1021 actatgccta ctacttctca gccttctctg ctgtcttctt ttttgtgccg ctgatcattt 1081 ccacggtctg ttatgtgtct atcattcgat gtcttagctc ttccgcagtt gccaaccgca 1141 gcaagaagtc ccgggctttg cccctgtcag ctgctgtttt ctgcatcttc atcatttgct 1201 tcggacccac aaacgtcctc ctgattgcgc atcactcatt cctttctcac acttccacca 1261 cagaggctgc ctactccgcc tacctcctct gtgtctgtgt cagcagcata agctcgtgca 1321 tcgaccccct aatttactat tacgcttcct ctgagtgcca gaggtacgtc tacagtatct 1381 tatgctgcaa agaaagttcc gatcccagca gttataacag cagtgggcag ttgatggcaa 1441 gtaaaatgga tacctgctct agtaacccga ataacagcac atacaaaaag ctgttaactt 1501 aggaaaaggg actgctggga ggttaaaaaQ aaaagtttac aaaagtgaat aacctgagga 1561 ttctattagt ccccacccaa actttattga ctcacctccc aaaacaacag atgtacgact 1621 tgcatacctg ctttttatgg gagctgtcaa catgtattt ttgtcaatta ccagaaagat 1681 aacaggacga gatgacggtg ttattccaag ggaatattgc caatgctaca gtaataaatg 1741 aatgtcactt ctggatacag ctaggtgaca ratacatact tacatgtgtg tatatgtaga 1801 tgtatgcaca cacacatatt atttgcautg cagtatagaa taggcactc aaaacactct 1861 ttccccgcac cccagcaact atgaaaataa tctctgattc cctgatttaa tacgcaaagt 1921 ctaggttggt agagtcagc cctgaacatt =atggtgtt caccaacagt gagagactcc 1981 atagtttggg cccgtaccac tttgcaaatc aagtgtattt tgaaattgtt tgacggcaag WO 00/09525 1331 PCTIUS99/17712 2041 arttaagtta ttaagaggta agacrtagta ctatctgtgc gtagaagttc taatgttttc 2101 aattttaaac atatccaagt ttgaattcct aaaattatgg aaacagatga aaaacctctq 2161 cctgatatg ggtagtattt ttacatttt acacactgta cacataaacc aaaactgagc 2221 ataagcctc tagtgaatgt aggctugctt tcagagtagg ctattcctga gactgcatg 2281 tgcccgcccc cgatggagga ctocaggcag cagacacatg ccagggccat gtcagacaca 2341 gattggccag aaaccttcct gctgagcctc acagcagtga gactggggcc actacatttg 2401 ctccatcctc ctgggattgg ctgtgaactg atcatgttta tgagaaactg gcaaagcaga 2461 atgtgatatc etaggaggta atgaccatga aagacttctc tacccatctt aaaaacaacg 2521 aaagaaggca tggacttctg gatgcccatc cactgggtgt aaacacatct agcagttgtt 2581 ctgaaatgtc agctgata tggaagcacc cattatgcgc tgtggccact ccaataggtg 2641 ctgagtgtac agagtggaat aagacagaga cctgccctca agagcaaagt agatcatgca 2701 tagagtgtga tgtatgtgta ataaatatgt ttcacacaaa caaggcctgt caactaaaga 2761 agtttgaaca tttgggttac tatttcttat ggttataact taatgaaaac aatgcagtac 2821 aggacatata ttttttaaaa taagtctgat ttaattgggc actatttatt tacaaatgtt 2881 ttgctcaata gattgctcaa atcaggtttt cttttaagaa tcaatcatgt cautctgctt 2941 agaaataaca gaagaaaata gaattgacat Lgaaatctag gaaaattatt ctataatttc 3001 catcactta agacttaatg agactttaaa agcatttttt aacctcctaa gtatcaagta 3061 tagaaaatct tcatggaatt cacaaagtaa tttggaaatt aggttgaaac atatctctta 3121 tcttacgaaa aaatggtagc attttaaaca aaatagaaag ttgcaaggca aatatttatt 3181 taaaagagca ggccaggcgc ggtggctcac gcctgtaatc ccagcacttt gggaggctga 3241 ggcgggtgga tcacgaggtc aggagatcga gaccaccg gctaacacgg tgaaacccgt 3301 ctctactaaa aatgcaaaaa aaattagccg ggcgtggtgg caggcacctg taaccccagc 3361 tactcgggag gctgaggcag gagactggcg tgaacccagg aggcggacct tgagtgagc 3421 cgagatccgcg ccactgtgct ccagcctggg caacagagca agactccatc tc (2) INFORMATION FOR SEQ ID NO:185: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 6836 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (xi)SEQUENCE DESCRIPTION: SEQ ID NO:185: 1 cctgcctgca cggcacagga gagcaaactt ctacagacag accaaggctt ccatttgctg 61 ctgacacactg gaactgaggt gaaattgtgc tccatgattt tacagatttc ataacgttta 121 agagacggga ctcaggtcat caaaatgaaa gccctcatct ttgcagctgc tggcctcctg 181 ctctgttgc ccactttttg tcagagtggc atggaaaatg atacaaacaa cttggcaaag 241 ccaaccttac ccattaagac ctttcgtgga gctcccccaa attcttttga agagttcccc 301 tttctgcct tggaaggctg gacaggagcc acgattactg taaaaattaa gtgccctgaa 361 gaaagtgctt cacatctcca tgtgaaaaa gctaccatgg ggtacctgac cagctcctta 421 agtactaaac tgatacctgc catctacctc ctggtgtttg tagttggtgt cccggccaat 481 gctgtgaccc tgtggatgct tttcttcagg accagatcca tctgtaccac tgtattctac 541 accaacctgg ccattgcaga ttttcttttt tgtgttacat tgccctttaa gaagcttat 601 catctcaatg ggaacaactg ggtatttgga gaggtcctgt gccgggccac cacagtcatc 661 tctatggca acatgtactg cccattctg ctccttgcct gatcagcat caaccgctac 721 ctggccatcg tccatccttt cacctaccgg ggcctgccca agcacaccta tgccttggta 781 acatgtggac tggtgtgggc aacagttttc ttatatatgc tgccattttt caractgaag 841 caggaatat atcttgttca gccagacac accacctgcc agatgttca caacacttgc 901 gagtccccat ctcccttcca actctattac ttcatctcct tggcattctt tggattctta 961 attccaattg tgcttatcat ctacgctat gcagccatca tccggacact taagcatac 1021 gacaagat ggtgtggta tgttaaggcg agtctcctca tccttgtgat ttttaccatt 1081 tgctttgctc caagcaatat tattcttatt atcaccatg ctaactacta ctacaacaac 1141 actgatggct tatattttat atatctcata gctttgtgcc tgggtagtct taatagttgc 1201 ttagatccat tcctttattt tctcatgtca aaaaccagaa atcactccac tgctacctt 1261 acaaaatagt gaaatgatct tagagaacaa ggacagccat cacagagaac gtctgttttc 1321 aagaacaaca taagcatagt gcaaggagct ccatttccga gctcctaaga aatatgcttc 1381 aaaggtcaaa cattacaaaa gcattagtag tttgtttgtt tgtttttgag actaagtctc 1441 actttatcac ccagactggc gtgcagtggc acaatcttgg ctcattgcaa cctctgcctc 1501 ccaggtcagc ctcccaagta gctgggatta caccaccatg cccagctact aaaaatactt 1561 gtatttttag aagagacggg gtttcaccat gttgaccagg ctggtcttga actcctgacc 1621 tcaagtgatc ttccggcctc agcctcccaa agtgctggat tacaggcgtg agccactgag 1681 ccagccagca ttagtaattt tgaaaaacac tttatcagta ttttaaaaat gttaatgcag 1741 gagaaaagat atcacaactc tatggaaaat gacatttcca tttgccttat tgctacttca 1801 agcactttaa atcaccatct tccctatttc 1 tcatgtgggg gcgactgctc cgtggcccc tggctgctggg gttcagcctg tctggcggca 61 cccagacccc cagcgtctac gacgagagcg ggagcaccgg aggtggtga gacagcacgc 121 cctcaatcct gcctgccccc cgcggctacc caggccaagt ctgtgccaat gacagtgaca 181 ccctggagct cccggacagc tcacgggcac tacttctggg ctgggtgccc accaggctgg 241 tgcccgccct ctatgggctg gacctggtgg tggggctgcc ggccaatggg crggcgctgt 301 aggtgctggc cacgcaggca cctcggctgc cctccaccat gctgctgatg aacctcgcga 361 ctactgacct cctactggcc cggcgctgc ccccgcggat cgcctaccac ctacgtggcc 421 aacgcaggcc cttcggggag gccgcctgcc gcctggccac ggccgcactc tatggtcaca WO 00/09525 1332 PCTIUS99/17712 481 tgtatggctc agtactgctg ctggccgccg tcagcctgga tcgctacctg gccctggtgc 541 acccgctgcg ggcccgcgcc ctqcgtggcc ggcgcctggc ccttggactc tacatggctg 601 cttggctcat ggcggccgcc ctggcactgc ccctgacact gcagcggcag accttccggc 661 tggcgcgctc cgatcgcgtg ctctgccatg acgcgctgcc cctggacgca caggcctccc 721 actggcaacc ggccttcacc tgcctggcgc tgttgggctg tttcctgccc ctgctggcca 781 tgctgctgtg ctacagggcc accctgcaca cgctggcggc cagcggccgg cgctacggcc 841 acgcgctgag gctgaccgca gtggtgctgg cctccgccgt ggccttcttc gtgcccagca 901 acctgctgct gctgctgcat tacteggace cgagccccag cgcctggggc aaccctatg 961 gtgcctacgt gcccagcctg gcgctgagca ccctcaacag ctgcgtggat cccttcatct 1021 actactacgt gtcggccgag ttcagggaca aggtgcgggc agggctcttc caacggtcgc 1081 cgggggacac cgtggcctcc aaggcctctg cggaaggggg cagccggggc atgggcaccc 1141 actcctcttt gctccagtga cacaaagtgg ggaaggctgt actgggtcga acagggtccc 1201 ttcccccact tcacgccc cctgggacct cagaatgtga ccttatttgg aaatagggtt 1261 gttacaactg tcactagcag aggtcactc ggagaagggt gggccttaca tccagtgtgg 1321 gtggtgtcct cataagataa ggagaggcca ggcctggtgg ctcacgcctg taatcccagc 1381 actttaagag gccaaggcgg atggatcact tgagcccagg agttcaacac cagcctgagc 1441 aacatggtaa aaccccatct ctaccaaaaa tacaaaaatt agctgggctt ggtggctggc 1501 gcctgtaatc ccagctactc angagactga ggcacgcacc cggg 301 cccgcaggcc agaatcaaaa gcaacaaatg ccaccttaga tccccggtca tttcttctca 361 ggaaccccaa tgataaatat gaaccatttt gggaggatga ggagaaaaat gaaagtgggt 421 taactgaata cagattagtc tccatcaata aaagcagtcc tcttcaaaaa caacttcctg 481 cattcatctc agaagatgcc tccggatatt tgaccagctc ctggctgaca ctctttgtcc 541 catctgtgta caccggagtq tttgtagtca gcctcccact aaacatcatg gccatcgttg 601 tgttcatcct gaaaatgaag gtcaagaagc cggcggtgqt gtacatgctg cacctggcca 661 cggcagatgt gctgtcgtg tctgtgctcc cctttaagat cagctattac ttttccggca 721 gtgattggca gtttgggtct gaattgtgtc gcttcgtcac tgcagcattt tactgtaaca 781 tgtacgcctc tatcttgctc atgacagtca taagcattga ccggtttctg gctgtggtgt 841 atcccatgca gtccctctcc tggcgtactc tgggaagggc ttccttcact tgtctggcca 901 tctgggcttt ggccatcgca ggggtagtgc ctctcgtcct caaggagcaa accatccagg 961 tgcccgggct caacatcact acctgtcatg atgtgctcaa tgaaaccctg ctcgaaggc 1021 actatgccta ctacttctca gccttctctg ctgtcttctt ttttgtgccg ctgatcattt 1081 ccacggtctg ttatgtgtct atcattcgat gtcttagctc ttccgcagtt gccaaccgca 1141 gcaagaagtc ccgggctttg ttcctgtcag ctgctgtttt ctgcatcttc atcatttgct 1201 tcggacccac aaacgtcctc ctgattgcgc attactcatt cctttctcac acttccacca 1261 cagaggctgc ctactttgcc tacctcctct gtgtctgtgt cagcagcata agctcgtgca 1321 tcgaccccct aatttactat tacgcttcct ctgagtgcca gaggtacgtc tacagtatct 1381 tatgctgcaa agaaagttcc gatcccagca gttataacag cagtgggcag ttgatggcaa 1441 gtaaaatgga tacctgctct agtaacctga ataacagcat atacaaaaag ctgttaactt 1501 aggaaaaggg actgctggga ggttaaaaag aaaagtttat aaaagtgaat aacctgagga 1561 ttctattagt ccccacccaa actttattga ttcacctcct aaaacaacag atgtacgact 1621 tgcatacctg ctttttatgg gagctgtcaa gcatgtattt ttgtcaatta ccagaaagat 1681 aacaggacga gatgacggtg ttattccaag ggaatattgc caatgctaca gtaataaatg 1741 aatgtcactt ctggatatag ctaggtgaca tatacatact tacatgtgtg tatatgtaga 1801 tgtatgcaca cacatatatt atttgcagtg cagtatagaa taggcacttt aaaacactct 1861 ttccccgcac cccagcaatt atgaaaataa tctctgattc cctgatttaa tatgcaaagt 1921 ctaggttggt agagtttagc cctgaacatt tcatggtgtt catcaacagt gagagactcc 1981 atagtttggg cttgtaccac ttttgcaaat aagtgtattt tgaaattgtt tgacggcaag 2041 gtttaagtta ttaagaggta agacttagta ctatctgtgc gtagaagttc tagtgttttc 2101 aattttaaac atatccaagt ttgaattcct aaaattatgg aaacagatga aaagcctctg 2161 ttttgatatg ggtagtattt tttacatttt acacactgta cacataagcc aaaactgagc 2221 ataagtcctc tagtgaatgt aggctggctt tcagagtagg ctattcctga gagctgcatg 2281 tgtccgcccc cgatggagga ctccaggcaq cagacacatg ccagggccat gtcagacaca 2341 gattggccag aaaccttcct gctgagcctc acagcagtga gactggggcc actacatttg 2401 ctccatcctc ctgggattgg ctgtgaactg atcatgttta tgagaaactg gcaaagcaga 2461 atgtgatatc ctaggaggta atgaccatga aagacttctc tacccatctt aaaaacaacg 2521 aaagaaggca tggacttctg gatgcccatc cactgggtgt aaacacatct agtagttgtt 2581 ctgaaatgtc agctgata tggaagcacc cattatgcgc tgtggccact ccaataggtg 2641 ctgagtgtac agagtggaat aagacagaga cctgccctca agagcaaagt agatcatgca 2701 tagagtgtga tgtatgtgta ataaatatgt ttcacacaaa caaggcctgt cagctaaaga 2761 agtttgaaca tttgggttac tatttcttgt ggttataact taatgaaaac aatgcagtac 2821 aggacatata ttttttaaaa taagtctgat ttaattgggc actatttatt tacaaatgtt 2881 ttgctcaata gattgctcaa atcaggtttt cttttaagaa tcaatcatgt cagtctgctt 2941 agaaataaca gaagaaaata gaattgacat tgaaatctag gaaaattatt ctataatttc 3001 catttactta agacttaatg agactttaaa agcatttttt aacctcctaa gtatcaagta 3061 tagaaaatct tcatggaatt cacaaagtaa tttggaaatt aggttgaaac atatctctta 3121 tcttacgaaa aaatggtagc atctaaaca aaatagaaag ttacaaggca aatgtttatt 3181 taaaagagca ggccaggcgc ggtggctcac gcctgtaatc ccagcacttt gggaggctga 3241 ggcgggtgga cacgagcc aggagatcga gaccatcctg gctaacacgg tgaaacccgt WO 00/09525 1333 PCT/US99/17712 3301 ctctactaaa aatgcaaaaa aaattagccg ggcgtggtgg caggcacctg tagtcccagc 3361 tactcgggag gctgaggcag gagactggcg tgaacccagg aggcggacct tgtagtgagc 3421 cgagatcgcg ccactgtgct ccagcctggg caacagagca agactccatc tc 351086

Claims (148)

1. A pharmaceutical composition, comprising a nucleic acid which comprises an oligonucleotide (oligo) consisting of up to about 15% adenosine (A), and which is effective for alleviating or inhibiting bronchoconstriction, allergy(ies) and/or inflammation, the oligo being anti-sense to a target selected from the group consisting of target genes and their corresponding mRNAs; genomic and mRNA flanking regions selected from the group consisting of 3' and 5' intron-exon borders and the juxta-section between coding and non-coding regions; and all mRNA segments encoding polypeptides associated with a disease(s) or condition(s) afflicting lung airways; combinations thereof; pharmaceutically acceptable salts thereof; and mixtures thereof.
2. The composition of claim 1, wherein the oligo consists of up to about 10% A.
3. The composition of claim 2, wherein the oligo consists of up to about 5% A.
4. The composition of claim 3, wherein the oligo consists of up to about 3% A.
5. The composition of claim 4, wherein the oligo is A-free.
6. The composition of claim 1, wherein the target gene is selected from the group consisting of target genes and mRNAs encoding polypeptides selected from the group consisting of transcription factors, stimulating and activating factors, interleukins, interleukin receptors, chemokines, chemokine receptors, endogenously produced specific and non-specific enzymes, immunoglobulins, antibody receptors, central nervous system (CNS) and peripheral nervous and non-nervous system receptors, CNS and peripheral nervous and non nervous system peptide transmitters, adhesion molecules, defensines, growth factors, vasoactive peptides and receptors, and binding proteins; and target genes and mRNAs corresponding to oncogenes, and flanking regions and intron and exon borders.
7. The agent of claim 6, wherein the encoded polypeptides are selected from the group consisting of NfKB Transcription Factor, Interleukin-8 Receptor (IL-8 R), Interleukin 5 Receptor (IL-5 R), Interleukin 4 Receptor (IL-4 R), Interleukin 3 Receptor (IL-3 R), Interleukin-1 P (IL-1 P), Interleukin 1 P Receptor (IL- 1p R), Eotaxin, Tryptase, Major Basic Protein, 2-adrenergic Receptor Kinase, Endothelin Receptor A, Endothelin Receptor B, Preproendothelin, Bradykinin B2 Receptor, IgE High Affinity Receptor, Interleukin 1 (IL-1), Interleukin 1 Receptor (IL-1 R), Interleukin 9 (IL-9), Interleukin-9 Receptor (IL-9 R), Interleukin 11 (IL-11), Interleukin-11 Receptor (IL-11 R), Inducible Nitric Oxide Synthase, Cyclooxygenase (COX), Intracellular Adhesion Molecule 1 (ICAM-1) Vascular Cellular Adhesion Molecule (VCAM), Rantes, Endothelial Leukocyte Adhesion Molecule (ELAM-1), Monocyte Activating Factor, Neutrophil Chemotactic Factor, Neutrophil Elastase, Defensin 1, 2 and 3, Muscarinic Acetylcholine Receptors, Platelet Activating Factor, Tumor Necrosis Factor a, 5 lipoxygenase, Phosphodiesterase IV, Substance P, Substance P Receptor, Histamine Receptor, Chymase, CCR-1 CC Chemokine Receptor, CCR-2 CC Chemokine Receptor, CCR-3 CC Chemokine Receptor, CCR-4 CC Chemokine Receptor, CCR-5 CC Chemokine Receptor, Prostanoid Receptors, GATA-3 Transcription Factor, Neutrophil Adherence Receptor, MAP Kinase, Interleukin-9 (IL-9), NFAT Transcription Factors, STAT 4, MIP l a, MCP-2, MCP-3, MCP-4, Cyclophillins, Phospholipase A2, Basic Fibroblast Growth Factor, Metalloproteinase, CSBP/p3 8 MAP Kinase, Tryptose Receptor, PDG2, Interleukin-3 (IL-3), Interleukin- 1P (IL- 1 P), Cyclosporin A Binding Protein, FK5-Binding Protein, a4p1 Selectin, Fibronectin, a4p7 Selectin, Mad CAM-1, LFA-1 (CD11a/CD18), PECAM-1, LFA-1 Selectin, C3bi, PSGL-1, E-Selectin, P-Selectin, CD-34, L-Selectin, p150,95, Mac-I (CD1lb/CD18), Fucosyl transferase, VLA-4, CD-18/CD11a, CDllb/CD18, ICAM2 and ICAM3, C5a, CCR3 (Eotaxin Receptor), CCR1, CCR2, CCR4, CCR5, LTB-4, AP-1 Transcription Factor, Protein kinase C, Cysteinyl Leukotriene Receptor, Tachychinnen Receptors (tach R), IKB Kinase 1 & 2, STAT 6, c-mas and NF Interleukin-6 (NF-IL-6).
8. The composition of claim 1, wherein at least one A is substituted by a universal base selected from the group consisting of heteroaromatic bases which bind to a thymidine base but have antagonist activity and less than about 0.3 of the adenosine base agonist activity at the adenosine A,, A 2 b and A, receptors, and heteroaromatic bases which have no activity or have an agonist activity at the adenosine A, receptor.
9. The composition of claim 8, wherein all As are substituted by universal bases selected from the group consisting of heteroaromatic bases which bind to a thymidine base but have antagonist activity and less than about 0.3 of the adenosine base agonist activity at the adenosine A, A 2 b and A 3 receptors, and heteroaromatic bases which have no activity or have an agonist activity at the adenosine A,, receptor.
10. The composition of claim 8, wherein the heteroaromatic bases are selected from the group consisting of pyrimidines and purines, which may be substituted by 0, halo, NH 2 , SH, SO, SO, SO 3 , COOH and branched and fused primary and secondary amino, alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, alkoxy, alkenoxy, acyl, cycloacyl, arylacyl, alkynoxy, cycloalkoxy, aroyl, arylthio, arylsulfoxyl, WO 00/09525 1335 PCT/US99/17712 halocycloalkyl, alkylcycloalkyl, alkenylcycloalkyl, alkynylcycloalkyl, haloaryl, alkylaryl, alkenylaryl, alkynylaryl, arylalkyl, arylalkenyl, arylalkynyl, arylcycloalkyl, which may be further substituted by 0, halo, NH 2 , primary, secondary and tertiary amine, SH, SO, SO,, SO 3 , cycloalkyl, heterocycloalkyl and heteroaryl.
11. The composition of claim 10, wherein the pyrimidines and purines are substituted at positions 1, 2, 3, 4, 7 and 8.
12. The composition of claim 11, wherein the pyrimidines and purines are selected from the group consisting of theophylline, caffeine, dyphylline, etophylline, acephylline piperazine, bamifylline, enprofylline and xantine having the chemical formula 0 O N I wherein R' and R2 are independently H, alkyl, alkenyl or alkynyl and 3 is H, aryl, dicycloalkyl, dicycloalkenyl, dicycloalkynyl, cycloalkyl, cycloalkenyl, cycloalkynyl, 0-cycloalkyl, 0-cycloalkenyl, 0 cycloalkynyl, NH-alkylamino-ketoxyalkyloxy-aryl and mono and dialkylaminoalkyl-N-alkylamino-SO 2 aryl.
13. The composition of claim 12, wherein the universal base is selected from the group consisting of 3-nitropyrrole-2'-deoxynucleoside, 5-nitro-indole, 2-deoxyribosyl-(5-nitroindole), 2-deoxyribofuranosyl-(5 nitroindole), 2'-deoxyinosine, 2'-deoxynebularine, 6H, 8H-3,4-dihydropyrimido [4,5-c] oxazine-7-one or 2-amino 6-methoxyaminopurine.
14. The composition of claim 1, where a methylated cytocine ('C) is substituted for at least one CpG dinucleotide if present in the oligo(s). .
15. The composition of claim 1, wherein at least one nucleotide linking residue of the anti-sense oligonucleotide(s) is a residue selected from the group consisting of methylphosphonate, phosphotriester, phosphorothioate, phosphorodithioate, boranophosphate, formacetal, thioformacetal, thioether, carbonate, carbamate, sulfate, sulfonate, sulfamate, sulfonamide, sulfone, sulfite, sulfoxide, sulfide, hydroxylamine, methylene(methyimino), methyleneoxy (methylimino), 2'-O-methyl, phosphoramidate residues and combinations thereof.
16. The agent of claim 15, wherein all nucleotide linking residues are selected from the group consisting of methylphosphonate, phosphotriester, phosphorothioate, phosphorodithioate, boranophosphate, formacetal, thioformacetal, thioether, carbonate, carbamate, sulfate, sulfonate, sulfamate, sulfonamide, sulfone, sulfite, sulfoxide, sulfide, hydroxylamine, methylene(methyimino), methyleneoxy (methylimino), 2'-O-methyl, phosphoramidate residues and combinations thereof.
17. The composition of claim 1, wherein the anti-sense oligonucleotide comprises about 7 to 60 mononucleotides.
18. The composition of claim 1, wherein the anti-sense oligonucleotide comprises fragments 1 to 1670 (SEQ ID NOS: 11 through 1680).
19. The composition of claim 1, wherein the anti-sense oligonucleotide is linked to an agent selected from the group consisting of cell internalized or up-taken agent(s) and cell targeting agents.
20. The composition of claim 19, wherein the cell internalized or up taken agent is selected from the group consisting of transferrin, asialoglycoprotein and streptavidin.
21. The composition of claim 19, wherein the nucleic acid is linked to a vector.
22. The vector of claim 21, which comprises a prokaryotic or eukaryotic vector.
23. The composition of claim 1, wherein the oligo is hybridized to a ribonucleic acid.
24. A cell, comprising the agent of claim 1.
25. The composition of claim 1, further comprising a carrier.
26. The composition of claim 25, wherein the carrier comprises a biologically acceptable carrier.
27. The composition of claim 26, wherein the carrier comprises a pharmaceutically or veterinarily acceptable carrier.
28. The composition of claim 25, wherein the carrier is selected from the group consisting of gaseous, liquid, solid carriers and mixtures thereof.
29. The composition of claim 25, further comprising an agent selected from the group consisting of other therapeutic agents, surfactants, antioxidants, flavoring and coloring agents, fillers, volatile oils, buffering agents, dispersants, RNA inactivating agents, anti-oxidants, flavoring agents, propellants and preservatives.
30. The composition of claim 29, comprising the nucleic acid, a surfactant and a carrier. WO 00/09525 1336 PCTIUS99/17712
31. The composition of claim 29, wherein the surfactant is selected from the group consisting of surfactant protein A, surfactant protein B, surfactant protein C, surfactant protein D and surfactant protein and active fragments thereof, non-dipalmitoyl disaturated phosphatidylcholine, dipalmitoylphosphatidylcholine, phosphatidylcholine, phosphatidylglycerol, phosphatidylinositol, phosphatidylethanolamine, phosphatidylserine, phosphatidic acid, ubiquinones, lysophosphatidylethanolamine, lysophosphatidylcholine, palmitoyl-lysophosphatidylcholin, dehydroepiandrosterone, dolichols, sulfatidic acid, glycerol-3-phosphate, dihydroxyacetone phosphate, glycerol, glycero-3-phosphocholine, dihydroxyacetone, palmitate, cytidine diphosphate (CDP) diacylglycerol, CDP choline, choline, choline phosphate, artificial lamellar bodies vehicles for surfactant components, omega-3 fatty acids, polyenic acid, polyenoic acid, lecithin, palmitic acid, non-ionic ethylene and/or propylene oxide block copolymers, polyoxypropylene, polyoxyethylene, poly (vinyl amine) with dextran and/or alkanoyl side chains, Brij 35, Triton X-100, ALEC, Exosurf, Survant and Atovaquone.
32. The composition of claim 31, wherein the RNA inactivating agent comprises an enzyme, preferably a ribozyme.
33. The composition of claim 1, wherein the anti-sense oligonucleotide is present in an amount of about 0.01 to about 99.99 w/w of the composition.
34. The composition of claim 33, wherein the anti-sense oligonucleotide is present in an amount of about i to about 40 w/w of the composition.
35. The composition of claim 34, wherein the anti-sense oligonucleotide is present in an amount of about 5 to about 20 w/w of the composition.
36. A formulation, comprising the composition of claim 25, selected from the group consisting of systemic and topical formulations.
37. The formulation of claim 36, selected from the group consisting of oral, intrabuccal, intrapulmonary, rectal, intrauterine, intratunor, intracranial, nasal, intramuscular, subcutaneous, intravascular, intrathecal, inhalable, transdermal, intradermal, intracavitary, implantable, iontophoretic, ocular, vaginal, intraarticular, otical, intiavenous, intramuscular, intraglandular, intraorgan, intralymphatic, implantable, slow release and enteric coating formulations.
38. The formulation of claim 37, which is an oral formulation, wherein the carrier is selected from the group consisting of solid and liquid carriers.
39. The oral formulation of claim 38, wherein the liquid carrier is selected from the group consisting of solutions, suspensions, and oil-in-water and water-in-oil emulsions.
40. The oral formulation of claim 38, which is selected from the group consisting of a powder, dragees, tablets, capsules, sprays, aerosols, solutions, suspensions and emulsions.
41. The formulation of claim 36, which is a topical formulation, wherein the carrier is selected from the group consisting of creams, gels, ointments, sprays, aerosols, patches, solutions, suspensions and emulsions.
42. The formulation of claim 36, which is an injectable formulation, wherein the carrier is selected from the group consisting of aqueous and alcoholic solutions and suspensions, oily solutions and suspensions and oil-in-water and water-in-oil emulsions.
43. The formulation of claim 36, which is a rectal formulation in the form of a suppository.
44. The formulation of claim 36, which is a transdermal formulation, wherein the carrier is selected from the group consisting of aqueous and alcoholic solutions, oily solutions and suspensions and oil-in-water and water-in-oil emulsions.
45. The transdermal formulation of claim 36, which is an iontophoretic transdermal formulation, wherein the carrier is selected from the group consisting of aqueous and alcoholic solutions, oily solutions and suspensions and oil-in-water and water-in-oil emulsions, and wherein the formulation further comprises a transdermal transport promoting agent.
46. An implantable capsule or cartridge, comprising the formulation of claim 44.
47. The formulation of claim 36, wherein the carrier is selected from the group consisting of aqueous and alcoholic solutions and suspensions, oily solutions and suspensions and oil-in-water and water-in-oil emulsions.
48. The formulation of claim 36, wherein the carrier comprises a hydrophobic carrier.
49. The formulation of claim 48, wherein the carrier comprises lipid vesicles or particles.
50. The formulation of claim 49, wherein the vesicles comprise liposomes, and the particles comprise microcrystals.
51. The formulation of claim 50, wherein the vesicles comprise liposomes which comprise the anti sense oligonucleotide.
52. The formulation of claim 49, wherein the vesicles comprise N-(l-[ 2, 3-dioleoxyloxi] propyl) N,N,N- trimethyl- ammonium methylsulfate.
53. The formulation of claim 36, comprising a respirable or inhalable formulation.
54. The respirable or inhalable formulation of claim 53, comprising an aerosol.
55. The formulation of claim 36, in single or multiple unit form.
56. The formulation of claim 36, in bulk. WO 00/09525 1337 PCT/US99/17712
57. A kit, comprising a delivery device; in a separate container, the formulation of claim 36; and instructions for adding a carrier and for use of the formulation.
58. The kit of claim 57, wherein the delivery device comprises a nebulizer which delivers single metered doses of the formulation.
59. The kit of claim 58, wherein the nebulizer comprises an insufflator; and the composition is provided in a piercable or openable capsule or cartridge.
60. The kit of claim 58, wherein the delivery device comprises a pressurized inhaler; and the composition comprises a suspension, solution or dry formulation of the agent.
61. The kit of claim 57, further comprising, in a separate container, an agent selected from the group consisting of other therapeutic agents, surfactants, anti-oxidants, flavoring agents, fillers, volatile oils, dispersants, antioxidants, propellants, preservatives, buffering agents, RNA inactivating, cell-internalized or up-taken agents and coloring agents.
62. The kit of claim 61, comprising, in separate containers, a nucleic acid, a surfactant and a carrier.
63. The kit of claim 61, wherein the solvent is selected from the group consisting of organic solvents and organic solvents mixed with one or more co-solvents.
64. The kit of claim 57, wherein the composition is provided in a capsule or cartridge.
65. An in vivo method of delivering a nucleic acid comprising an anti-sense oligonucleotide (oligo) to a target polynucleotide associated with a disease(s) or condition(s) afflicting lung airways, comprising administering to a subject the composition of claim 1 comprising an amount of the nucleic acid effective to reach the target polynucleotide.
66. The method of claim 65, wherein the composition is administered into the subject's respiratory system.
67. The method of claim 65, wherein the agent is administered directly into the subject's lung (s).
68. The method of claim 65, wherein the amount of the agent is effective to bind to the nucleic acid.
69. The method of claim 65, wherein the agent is effective to reduce the production or availability, or to increase the degradation, of the target mRNA or to reduce the amount of the target polypeptide present in the lungs.
70. The method of claim 65, wherein the agent is administered as a respirable aerosol.
71. The method of claim 65, wherein the disease or condition is associated with obstruction of the subject's airways.
72. The method of claim 71, wherein the disease or condition is associated with asthma.
73. The method of claim 65, wherein the disease or condition is associated with inflammation.
74. The method of claim 65, wherein the disease or condition is associated with an allergy, and the target is selected from the group consisting of immunoglobulins and antibody receptors, genes and mRNAs encoding them, their genomic and mRNA flanking sequences and exon and intron borders of the gene (s) and mRNA(s).
75. The method of claim 65, wherein the disease or condition is associated with a malignancy or cancer, and the mRNA encodes a target selected from the group consisting of immunoglobulins and antibody receptors, genomic flanking sequences and genes and mRNAs encoding them and oncogenes.
76. The method of claim 65, wherein the composition is administered by a transdermal or systemic route.
77. The method of claim 76, wherein the composition is administered orally, intracavitarily, intranasally, intraanally, intravaginally, intrauterally, intraarticularly, transdermally, intrabucally, intravenously, subcutaneously, intramuscularly, intravascularly, intratumorously, intraglandularly, intraocularly, intracranial, into an organ, intravascularly, intrathecally, intralymphatically, intraotically, by implantation, by inhalation, intradermally, intrapulmonarily, intraotically, by slow release, by sustained release and by a pump.
78. The method of claim 65, wherein the subject is a mammal.
79. The method of claim 78, wherein the mammal is selected from the group consisting of humans and animals.
80. The method of claim 79, wherein the mammal is a human.
81. The method of claim 79, wherein the subject is an animal.
82. The method of claim 65, wherein the anti-sense oligonucleotide is administered in amount of about 0.005 to about 150 mg/kg body weight.
83. The method of claim 82, wherein the anti-sense oligonucleotide is administered in an amount of about 0.01 to about 75 mg/kg body weight. WO 00/09525 1338 PCT/US99/17712
84. The method of claim 83, wherein the anti-sense oligonucleotide is administered in an amount of about 1 to 50 mg/kg body weight.
85. The method of claim 65, which is a prophylactic method.
86. The method of claim 65, which is a therapeutic method.
87. The method of claim 65, wherein the oligo is obtained by (a) selecting fragments of a target nucleic acid having at least 4 contiguous nucleic acids selected from the group consisting of G and C; (b) obtaining a first oligonucleotide 4 to 60 nucleotides long which comprises the selected fragment and has a C and G nucleic acid content of up to and including about 15%; and (c) obtaining a second oligonucleotide 4 to 60 nucleotides long comprising a sequence which is anti-sense to the selected fragment, the second oligonucleotide having an A base content of up to and including about 15%.
88. The method of claim 61, wherein the oligo consists of up to about 10% A.
89. The method of claim 88, wherein the oligo consists of up to about 5% A.
90. The method of claim 88, wherein the oligo consists of up to about 3% A.
91. The method of claim 92, wherein the oligo is A-free.
92. The method of claim 65, wherein the target is selected from the group consisting of genes and mRNAs encoding polypeptides selected from the group consisting of transcription factors, stimulating and activating factors, interleukins, interleukin receptors, chemokines, chemokine receptors, endogenously produced specific and non-specific enzymes, immunoglobulins, antibody receptors, central nervous system (CNS) and peripheral nervous and non-nervous system receptors, CNS and peripheral nervous and non-nervous system peptide transmitters, adhesion molecules, defensines, growth factors, vasoactive peptides, peptide receptors and binding proteins; and genes and mRNAs corresponding to oncogenes.
93. The method of claim 65, wherein at least one A is substituted by a universal base selected from the group consisting of heteroaromatic bases which bind to a thymidine base but have antagonist activity and less than about 0.3 of the adenosine base agonist activity at the adenosine A,, A 2 , and A, receptors, and heteroaromatic bases which have no activity or have an agonist activity at the adenosine A2a receptor.
94. The method of claim 93, wehrein all As are substituted by universal bases selected from the group consisting of heteroaromatic bases which bind to a thymidine base but have antagonist activity and less than about 0.3 of the adenosine base agonist activity at the adenosine A,, A 2 b and A 3 receptors, and heteroaromatic bases which have no activity or have an agonist activity at the adenosine A 2 a receptor.
95. The method of claim 95, wherein the heteroaromatic bases are selected from the group consisting of pyrimidines and purines, which may be substituted by 0, halo, NH 2 , SH, SO, S02, SO3, COOH and branched and fused primary and secondary amino, alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, alkoxy, alkenoxy, acyl, cycloacyl, arylacyl, alkynoxy, cycloalkoxy, aroyl, arylthio, arylsulfoxyl, halocycloalkyl, alkylcycloalkyl, alkenylcycloalkyl, alkynylcycloalkyl, haloaryl, alkylaryl, alkenylaryl, alkynylaryl, arylalkyl, arylalkenyl, arylalkynyl, arylcycloalkyl, which may be further substituted by 0, halo, NH2, primary, secondary and tertiary amine, SH, SO, SO 2 , SO, cycloalkyl, heterocycloalkyl and heteroaryl.
96. The method of claim 95, wherein the pyrinidines and purines are substituted at positions 1, 2, 3, 4, 7 and 8.
97. The method of claim 96, wherein the pyrimidines and purines are selected from the group consisting of theophylline, caffeine, dyphylline, etophylline, acephylline piperazine, bamifylline, enprofylline and xantine having the chemical formula 0 I I I 0" C N I wherein R' and R 2 are independently H, alkyl, alkenyl or alkynyl and R 3 is H, aryl, dicycloalkyl, dicycloalkenyl, dicycloalkynyl, cycloalkyl, cycloalkenyl, cycloalkynyl, 0-cycloalkyl, 0-cycloalkenyl, 0 cycloalkynyl, NH 2 -alkylamino-ketoxyalkyloxy-aryl and mono and dialkylaminoalkyl-N-alkylamino-SO 2 aryl.
98. The method of claim 97, wherein the universal base is selected from the group consisting of 3 nitropyrrole-2'-deoxynucleoside, 5-nitro-indole, 2-deoxyribosyl-(5-nitroindole), 2-deoxyribofuranosyl-(5 nitroindole), 2'-deoxyinosine, 2'-deoxynebularine, 6H, 8H-3,4-dihydropyrimido [4,5-c] oxazine-7-one or 2-amino 6-methoxyaminopurine. WO 00/09525 1339 PCT/US99/17712
99. The method of claim 65, further comprising methylating at least one cytocine (mC) if a CpG dinocleotide if present in the oligo(s).
100. The method of claim 65, further comprising substituting at least one nucleotide linking residue of the anti-sense oligonucleotide(s) with a residue selected from the group consisting of methylphosphonate, phosphotriester, phosphorothioate, phosphorodithioate, boranophosphate, formacetal, thioformacetal, 'thioether, carbonate, carbamate, sulfate, sulfonate, sulfamate, sulfonamide, sulfone, sulfite, sulfoxide, sulfide, hydroxylamine, methylene(methyimino), methyleneoxy (methylimino), 2'-O-methyl, phosphoramidate residues, and combinations thereof.
101. The method of claim 100, wherein all nucleotide linking residues of the oligo are substituted.
102. The method of claim 65, further comprising linking the anti-sense oligonucleotide to an agent selected from the group consisting of cell internalized and up-taken agent(s) and cell targeting agents.
103. The method of claim 102, wherein the cell internalized or up taken agent is selected from the group consisting of transferrin, asialoglycoprotein, and streptavidin.
104. The method of claim 102, wherein the cell targeting agent is a vector.
105. The method of claim 104, wherein the vector to which the agent is operatively linked is a prokaryotic or eukaryotic vector.
106. A method of identifying segments in a target polynucleotide suitable for constructing oligonucleotides which are anti-sense to the target polynucleotide and have an adenosine (A) content of up to and including about 15% of all nucleotides, comprising (a) selecting fragments of a target polynucleotide acid having at least 4 contiguous nucleic acids selected from the group consisting of G and C; and (a) obtaining a first oligonucleotide 4 to 60 nucleotides long which comprises the selected fragment and has a C and G content of up to and including about 15%.
107. A method of obtaining oligonucleotides which are anti-sense to a target polynucleotide and have an adenosine content of .0 to up to and including about 15%, comprising conducting the method of claim 106; wherein the first oligonucleotide comprises a sequence which is anti-sense to the selected fragment and has an A content of up to and including about 15%.
108. The method of claim 107, further comprising, when the anti-sense fragment comprises at least one A, substituting at least one A with a universal base selected from the group consisting of heteroaromatic bases which bind to thymidine (T) but have less than about 0.3 of A's adenosine A,, A 2 b and A, receptor agonist activity; and heteroaromatic bases which have no activity or have adenosine A 2 , receptor agonist activity.
109. The method of claim 108, wherein the heteroaromatic bases are selected from the group consisting of pyrimidines and purines, which may be substituted by 0, halo, NH 2 , SH, SO, S02, SO 3 , COOH and branched and fused primary and secondary amino, alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, alkoxy, alkenoxy, acyl, cycloacyl, arylacyl, alkynoxy, cycloalkoxy, aroyl, arylthio, arylsulfoxyl, halocycloalkyl, alkylcycloalkyl, alkenylcycloalkyl, alkynylcycloalkyl, haloaryl, alkylaryl, alkenylaryl, alkynylaryl, arylalkyl, arylalkenyl, arylalkynyl, arylcycloalkyl, which may be further substituted by 0, halo, NH1 2 , primary, secondary and tertiary amine, SH, SO, SO2, SO3, cycloalkyl, heterocycloalkyl and heteroaryl.
110. The method of claim 109, wherein the pyrimidines and purines are substituted at positions 1, 2, 3, 4, 7 and 8.
111. The method of claim 109, wherein the pyrimidines and purines are selected from the group consisting of theophylline, caffeine, dyphylline, etophylline, acephylline piperazine, bamifylline, enprofylline and xantine having the chemical formula 0 M S C N N Pd wherein R' and ia. ULU m - , amzyi, auciy ur alkynyl and R' is H, aryl, dicycloalkyl, dicycloalkenyl, dicycloalkynyl, cycloalkyl, cycloalkenyl, cycloalkynyl, 0-cycloalkyl, 0-cycloalkenyl, 0 cycloalkynyl, NH 2 -alkylamino-ketoxyalkyloxy-aryl and mono and dialkylaminoalkyl-N-alkylamino-SO 2 aryl.
112. The method of claim 108, wherein the universal base is selected from the group consisting of 3 nitropyrrole-2'-deoxynucleoside, 5-nitro-indole, 2-deoxyribosyl-(5-nitroindole), 2-deoxyribofuranosyl-(5 nitroindole), 2'-dedxyinosine, 2'-deoxynebularine, 6H, 8H-3,4-dihydropyrimido [4,5-c] oxazine-7-one or 2-amino 6-methoxyaminopurine. WO 00/09525 1340 PCT/US99/17712
113. A method of treating a disease or condition associated with a target selected from-the group consisting of proteins, gene (s) and their corresponding mRNA(s) encoding the proteins, the genes and mRNA flanking regions and their intron and exon borders, associated with a disease or condition afflicting lung airways, comprising administering to a subject afflicted with the disease or condition the composition of claim 1 comprising an anti-bronchoconstriction, anti-allergic and/or anti-inflammatory effective amount of the nucleic acid.
114. The method of claim 113, wehrein the amount of nucleic acid administered is effective to reduce the production or availability, or to increase the degradation, of the mRNA, or to reduce the amount of the polypeptide present in the lungs.
115. The method of claim 113, wherein the nucleic acid is administered directly to the lung (s) of the subject.
116. The method of claim 113, wherein the nucleic acid is administered as a respirable aerosol.
117. The method of claim 113, wherein the disease or condition is a disease or condition afflicting the lung (s).
118. The method of claim. 117, wherein the disease or condition is associated with obstruction of the subject's airways.
119. The method of claim 117, wherein the disease or condition is associated with asthma.
120. The method of claim 117, wherein the disease or condition is associated with inflammation.
121. The method of claim 113, wherein the disease or condition is associated with allergy (ies), and the target is selected from the group consisting of immunoglobulins and antibody receptors, gene(s) and corresponding mRNA(s) encoding them, the genes and mRNA flanking regions and intron and exon borders.
122. The method of claim 113, wherein the disease or condition is associated with a malignancy or cancer; and the target is selected from the group consisting of immunoglobulins and antibody receptors, gene(s) and mRNA(s) encoding them, gene(s) and mRNA(s) associated with oncogenes, genomic and mRNA flanking regions and exon and intron borders.
123. The method of claim 113, wherein the composition is administered by a topical or systemic route.
124. The method of claim 123, wherein the composition is administered orally, intracavitarily, intranasally, intraanally, intravaginally, intrauterally, intraarticularly, intraotically, intralymphatically, transdermally, intrabucally, intravenously, subcutaneously, intramuscularly, intratumorously, intraglandularly, intraocularly, intracranial, into an organ, intravascularly, intrathecally, by implantation, by inhalation, intradermally, intrapulmonarily, into the ear, by slow release, by sustained release and by a pump.
125. The method of claim 124, wherein the subject is a mammal.
126. The method of claim 125, wherein the mammals are selected from the group consisting of humans and animals.
127. The method of claim 113, wherein the anti-sense oligonucleotide is administered in amount of about 0.005 to about 150 mg/kg body weight.
128. The method of claim 127, wherein the anti-sense oligonucleotide is administered in an amount of about 0.01 to about 75 mg/kg body weight.
129. The method of claim 130, wherein the anti-sense oligonucleotide is administered in an amount of about 1 to about 50 mg/kg body weight.
130. The method of claim 113, which is a prophylactic method.
131. The method of claim 113, which is a therapeutic method.
132. A method of producing anti-sense oligonucleotide(s) (oligos) consisting of up to and including about 15% adenosine (A), comprising selecting a target from the group consisting of polypeptides associated with a disease(s) and/or condition(s) afflicting lung airways, genes and RNAs encoding them, the genomic and mRNA flanking regions and the gene(s) and mRNA(s) intron and exon borders; obtaining the sequence of a mRNA(s) selected from the group consisting of mRNAs corresponding to the target gene(s) and mRNAs encoding the target polypeptide(s), genomic and mRNA flanking regions and the genes and mRNAs intron and exon borders; selecting at least one segment of the mRNA(s); synthesizing one or more oligo anti-sense to the selected mRNA segment(s); and substituting, if necessary, a universal base(s) for one or more A(s) to reduce the content of A present in the oligo to up to about 15% of all nucleotides.
133. The method of claim 132, wherein the universal base is selected from the group consisting of heteroaromatic bases which bind to a thymidine base but have antagonist activity and less than about 0.3 of the adenosine base agonist activity at the adenosine A 1 , A 2 b and A, receptors, and heteroaromatic bases which have no activity or have an agonist activity at the adenosine A, receptor.
134. The method of claim 132, wherein all As are substituted with universal bases selected from the group consisting of heteroaromatic bases which bind to a thymidine base but have antagonist activity and less than WO 00/09525 1341 PCTIUS99/17712 about 0.3 of the adenosine base agonist activity at the adenosine A,, A 2 ,, and A 3 receptors, and heteroaromatic bases which have no activity or have an agonist activity at the adenosine A,. receptor.
135. The method of claim 133, wherein the heteroaromatic bases are selected from the group consisting of pyrimidines and purines, which may be substituted by 0, halo, NH 2 , SH, SO, S02, SO2, COOH and branched and fused primary and secondary amino, alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, alkoxy, alkenoxy, acyl, cycloacyl, arylacyl, alkynoxy, cycloalkoxy, aroyl, arylthio, arylsulfoxyl, halocycloalkyl, alkylcycloalkyl, alkenylcycloalkyl, alkynylcycloalkyl, haloaryl, alkylaryl, alkenylaryl, alkynylaryl, arylalkyl, arylalkenyl, arylalkynyl, arylcycloalkyl, which may be further substituted by 0, halo, NH 2 , primary, secondary and tertiary amine, SH, SO, SO2, SO2, cycloalkyl, heterocycloalkyl and heteroaryl.
136. The method of claim 135, wherein the pyrimidines and purines are substituted at positions 1, 2, 3, 4, 7 and 8.
137. The method of claim 135, wherein the pyrimidines and purines are selected from the group consisting of theophylline, caffeine, dyphylline, etophylline, acephylline piperazine, bamifylline, enprofylline and xantine having the chemical formula 0 M II I CN 0 N N wherein R' and. R 2 are independently H, alkyl, alkenyl or alkynyl and R 3 is H, aryl, dicycloalkyl, dicycloalkenyl, dicycloalkynyl, cycloalkyl, cycloalkenyl, cycloalkynyl, O-cycloalkyl, 0-cycloalkenyl, 0 cycloalkynyl, NH 2 -alkylamino-ketoxyalkyloxy-aryl and mono and dialkylaminoalkyl-N-alkylamino-SO 2 aryl.
138. The method of claim 135, wherein the universal base is selected from the group consisting of 3 nitropyrrole-2'-deoxynucleoside, 5-nitro-indole, 2-deoxyribosyl-(5-nitroindole), 2-deoxyribofuranosyl-(5 nitroindole), 2'-deoxyinosine, 2'-deoxynebularine, 6H, 8H-3,4-dihydropyriniido [4,5-c] oxazine-7-one or 2-amino 6-methoxyaminopurine.
139. The method of claim 132, wherein the proportion of A in the oligo is reduced to up to about 10%.
140. The method of claim 139, wherein the proportion of A in the oligo is reduced to up to about 5%.
141. The method of claim 140, wherein the proportion of A in the oligo is reduced to up to about 3%.
142. The method of claim 141, wherein the proportion of A in the oligo is reduced to about 0.
143. The method of claim 139, wherein the selected segment contains less than about 15% T.
144. The method of claim 132, further comprising substituting a methylated cytosine for cytosine in at least one CpG dinucleotide present in the anti-sense oligo(s).
145. The method of claim 132, wherein the anti-sense oligo(s) are about 7 to about 60 nucleotides long.
146. The method of claim 132, wherein the target is selected from the group consisting of transcription factors, stimulating and activating factors, interleukins, interleukin receptors, chemokines, chemokine receptors, endogenously produced specific and non-specific enzymes, inmunoglobulins, antibody receptors, central nervous system (CNS) and peripheral nervous and non-nervous system receptors, CNS and peripheral nervous and non nervous system peptide transmitters, adhesion molecules, selectins, defensines, growth factors, vasoactive peptides, vasoactive peptide receptors, and binding proteins and oncogenes.
147. The method of claim 146, wherein the target genes are selected from the group consisting of oncogenes.
148. An anti-sense oligonucleotide produced by the method of claim 132.
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