Nothing Special   »   [go: up one dir, main page]

ATE407205T1 - Verbesserung in bezug auf bindungsproteine bei der erkennung von dna - Google Patents

Verbesserung in bezug auf bindungsproteine bei der erkennung von dna

Info

Publication number
ATE407205T1
ATE407205T1 AT95928576T AT95928576T ATE407205T1 AT E407205 T1 ATE407205 T1 AT E407205T1 AT 95928576 T AT95928576 T AT 95928576T AT 95928576 T AT95928576 T AT 95928576T AT E407205 T1 ATE407205 T1 AT E407205T1
Authority
AT
Austria
Prior art keywords
improvement
binding proteins
zinc finger
dna detection
binding
Prior art date
Application number
AT95928576T
Other languages
English (en)
Inventor
Yen Choo
Aaron Klug
Isidro Sanchez-Garcia
Original Assignee
Gendaq Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB9416880A external-priority patent/GB9416880D0/en
Priority claimed from GB9422534A external-priority patent/GB9422534D0/en
Priority claimed from GBGB9514698.1A external-priority patent/GB9514698D0/en
Application filed by Gendaq Ltd filed Critical Gendaq Ltd
Application granted granted Critical
Publication of ATE407205T1 publication Critical patent/ATE407205T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4705—Regulators; Modulating activity stimulating, promoting or activating activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/02—Libraries contained in or displayed by microorganisms, e.g. bacteria or animal cells; Libraries contained in or displayed by vectors, e.g. plasmids; Libraries containing only microorganisms or vectors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/09—Fusion polypeptide containing a localisation/targetting motif containing a nuclear localisation signal
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/80—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor
    • C07K2319/81—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor containing a Zn-finger domain for DNA binding

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Plant Pathology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Virology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
AT95928576T 1994-08-20 1995-08-17 Verbesserung in bezug auf bindungsproteine bei der erkennung von dna ATE407205T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9416880A GB9416880D0 (en) 1994-08-20 1994-08-20 Improvements in or relating to binding proteins for recognition of DNA
GB9422534A GB9422534D0 (en) 1994-11-08 1994-11-08 Improvements in or relating to binding proteins for recognition of DNA
GBGB9514698.1A GB9514698D0 (en) 1995-07-18 1995-07-18 Improvements in or relating to binding proteins for recognition of DNA

Publications (1)

Publication Number Publication Date
ATE407205T1 true ATE407205T1 (de) 2008-09-15

Family

ID=27267339

Family Applications (2)

Application Number Title Priority Date Filing Date
AT95928576T ATE407205T1 (de) 1994-08-20 1995-08-17 Verbesserung in bezug auf bindungsproteine bei der erkennung von dna
AT08015286T ATE524545T1 (de) 1994-08-20 1995-08-17 Verbesserungen bei oder im zusammenhang mit bindeproteinen zur erkennung von dna

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT08015286T ATE524545T1 (de) 1994-08-20 1995-08-17 Verbesserungen bei oder im zusammenhang mit bindeproteinen zur erkennung von dna

Country Status (8)

Country Link
US (7) USRE45795E1 (de)
EP (2) EP0781331B1 (de)
JP (2) JP4118327B2 (de)
AT (2) ATE407205T1 (de)
AU (1) AU698152B2 (de)
CA (1) CA2196419C (de)
DE (1) DE69535829D1 (de)
WO (1) WO1996006166A1 (de)

Families Citing this family (400)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
DK1279731T3 (da) 1991-03-01 2007-09-24 Dyax Corp Fremgangsmåde til udvikling af bindende miniproteiner
US6140466A (en) 1994-01-18 2000-10-31 The Scripps Research Institute Zinc finger protein derivatives and methods therefor
US20050084885A1 (en) * 1994-01-18 2005-04-21 The Scripps Research Institute Zinc finger protein derivatives and methods therefor
GB9824544D0 (en) * 1998-11-09 1999-01-06 Medical Res Council Screening system
AU726759B2 (en) * 1994-08-20 2000-11-23 Gendaq Limited Improvements in or relating to binding proteins for recognition of DNA
US7262055B2 (en) 1998-08-25 2007-08-28 Gendaq Limited Regulated gene expression in plants
US7285416B2 (en) * 2000-01-24 2007-10-23 Gendaq Limited Regulated gene expression in plants
ATE407205T1 (de) 1994-08-20 2008-09-15 Gendaq Ltd Verbesserung in bezug auf bindungsproteine bei der erkennung von dna
GB9710809D0 (en) * 1997-05-23 1997-07-23 Medical Res Council Nucleic acid binding proteins
GB9710807D0 (en) * 1997-05-23 1997-07-23 Medical Res Council Nucleic acid binding proteins
WO1999021991A1 (en) * 1997-10-29 1999-05-06 Shanghai Second Medical University Bmzf12: a zinc finger gene cloned from bone marrow
US6410248B1 (en) 1998-01-30 2002-06-25 Massachusetts Institute Of Technology General strategy for selecting high-affinity zinc finger proteins for diverse DNA target sites
WO1999045132A1 (en) * 1998-03-02 1999-09-10 Massachusetts Institute Of Technology Poly zinc finger proteins with improved linkers
JP2002505341A (ja) * 1998-03-06 2002-02-19 オックスフォード バイオメディカ（ユーケイ）リミテッド プロドラッグの活性化の増強
ATE336578T1 (de) 1998-03-17 2006-09-15 Gendaq Ltd Nukleinsäurebindungsproteine
EP1112355A1 (de) * 1998-09-14 2001-07-04 Aston University Gen- und proteinbibliotheken, und damit in zusammenhang stehende verfahren
US20050086718A1 (en) 1999-03-23 2005-04-21 Mendel Biotechnology, Inc. Plant transcriptional regulators of abiotic stress
US7897843B2 (en) 1999-03-23 2011-03-01 Mendel Biotechnology, Inc. Transcriptional regulation of plant biomass and abiotic stress tolerance
US6806062B1 (en) * 1998-10-05 2004-10-19 Novozymes A/S Fungal transcriptional activator useful in methods for producing polypeptides
US6140081A (en) * 1998-10-16 2000-10-31 The Scripps Research Institute Zinc finger binding domains for GNN
US6534261B1 (en) * 1999-01-12 2003-03-18 Sangamo Biosciences, Inc. Regulation of endogenous gene expression in cells using zinc finger proteins
US6453242B1 (en) 1999-01-12 2002-09-17 Sangamo Biosciences, Inc. Selection of sites for targeting by zinc finger proteins and methods of designing zinc finger proteins to bind to preselected sites
US7013219B2 (en) * 1999-01-12 2006-03-14 Sangamo Biosciences, Inc. Regulation of endogenous gene expression in cells using zinc finger proteins
US7070934B2 (en) 1999-01-12 2006-07-04 Sangamo Biosciences, Inc. Ligand-controlled regulation of endogenous gene expression
US6599692B1 (en) * 1999-09-14 2003-07-29 Sangamo Bioscience, Inc. Functional genomics using zinc finger proteins
US20030104526A1 (en) * 1999-03-24 2003-06-05 Qiang Liu Position dependent recognition of GNN nucleotide triplets by zinc fingers
US7030215B2 (en) 1999-03-24 2006-04-18 Sangamo Biosciences, Inc. Position dependent recognition of GNN nucleotide triplets by zinc fingers
US6794136B1 (en) 2000-11-20 2004-09-21 Sangamo Biosciences, Inc. Iterative optimization in the design of binding proteins
CA2374365A1 (en) 1999-05-28 2000-12-07 Sangamo Biosciences, Inc. Gene switches
CA2369855A1 (en) * 1999-05-28 2001-01-04 Sangamo Biosciences, Inc. Molecular switches
GB9915126D0 (en) 1999-06-30 1999-09-01 Imp College Innovations Ltd Control of gene expression
AU5912100A (en) * 1999-07-02 2001-01-22 Scripps Research Institute, The Method for determination of peptide-binding agent interaction
EP1230355A2 (de) * 1999-10-01 2002-08-14 Sangamo Biosciences Inc. Dna bibliothek und methoden zu deren verwendung für die selektion und das design von polypeptiden
EP1950306A1 (de) 1999-11-17 2008-07-30 Mendel Biotechnology, Inc. Umweltstress-Toleranzgene
BR0015628A (pt) 1999-11-17 2002-12-24 Mendel Biotechnology Inc Planta, polinucleotìdeo, vetor, célula, composição, polipeptìdeo, métodos para produzir uma planta e para identificar um fator que é modulado por, ou interage com, um polipeptìdeo codificado por um polinucleotìdeo, uma molécula que module a atividade ou a expressão de um polinucleotìdeo ou polipeptìdeo de interesse e uma sequência similar ou homóloga a um ou mais polinucleotìdeos, e, sistema integrado, meio computadorizado ou legìvel em computador
ATE309536T1 (de) * 1999-12-06 2005-11-15 Sangamo Biosciences Inc Methoden zur verwendung von randomisierten zinkfingerprotein-bibliotheken zur identifizierung von genfunktionen
CA2398155C (en) * 2000-01-24 2011-07-19 Sangamo Biosciences, Inc. Methods and compositions for linking binding domains in nucleic acid binding proteins
WO2001059450A2 (en) * 2000-02-08 2001-08-16 Sangamo Biosciences, Inc. Cells expressing zinc finger protein for drug discovery
US20020061512A1 (en) * 2000-02-18 2002-05-23 Kim Jin-Soo Zinc finger domains and methods of identifying same
US7923542B2 (en) 2000-04-28 2011-04-12 Sangamo Biosciences, Inc. Libraries of regulatory sequences, methods of making and using same
AU2001255748B2 (en) * 2000-04-28 2006-08-10 Sangamo Therapeutics, Inc. Methods for binding an exogenous molecule to cellular chromatin
GB2365011A (en) * 2000-04-28 2002-02-13 Sangamo Biosciences Inc Methods for the characterisation of regulatory DNA sequences
WO2001083819A2 (en) 2000-04-28 2001-11-08 Sangamo Biosciences, Inc. Methods for designing exogenous regulatory molecules
US6610489B2 (en) 2000-04-28 2003-08-26 Sangamo Biosciences, Inc. Pharmacogenomics and identification of drug targets by reconstruction of signal transduction pathways based on sequences of accessible regions
US20040039175A1 (en) * 2000-05-08 2004-02-26 Yen Choo Modulation of viral gene expression by engineered zinc finger proteins
US6492117B1 (en) * 2000-07-12 2002-12-10 Gendaq Limited Zinc finger polypeptides capable of binding DNA quadruplexes
US20030082561A1 (en) * 2000-07-21 2003-05-01 Takashi Sera Zinc finger domain recognition code and uses thereof
JP2004519211A (ja) * 2000-07-21 2004-07-02 シンジェンタ パーティシペーションズ アーゲー 亜鉛フィンガードメイン認識コードおよびその使用
WO2002015675A1 (en) 2000-08-22 2002-02-28 Mendel Biotechnology, Inc. Genes for modifying plant traits iv
WO2002018648A2 (en) * 2000-08-25 2002-03-07 President And Fellows Of Harvard College Analysis of binding interactions
WO2002020565A2 (en) 2000-09-08 2002-03-14 Universität Zürich Collections of repeat proteins comprising repeat modules
US6905816B2 (en) * 2000-11-27 2005-06-14 Intelligent Medical Devices, Inc. Clinically intelligent diagnostic devices and methods
US7026462B2 (en) 2000-12-07 2006-04-11 Sangamo Biosciences, Inc. Regulation of angiogenesis with zinc finger proteins
US7067317B2 (en) * 2000-12-07 2006-06-27 Sangamo Biosciences, Inc. Regulation of angiogenesis with zinc finger proteins
WO2002057293A2 (en) 2001-01-22 2002-07-25 Sangamo Biosciences, Inc. Modified zinc finger binding proteins
WO2002057308A2 (en) * 2001-01-22 2002-07-25 Sangamo Biosciences, Inc. Zinc finger polypeptides and their use
WO2002060477A1 (en) * 2001-01-31 2002-08-08 Human Genome Sciences, Inc. Scaffolded fusion polypeptides, compositions for making the same and methods of using the same
US7067617B2 (en) 2001-02-21 2006-06-27 The Scripps Research Institute Zinc finger binding domains for nucleotide sequence ANN
JP4128955B2 (ja) * 2001-08-17 2008-07-30 トゥールゲン・インコーポレイテッド ジンクフィンガードメインライブラリー
WO2003027247A2 (en) 2001-09-24 2003-04-03 Sangamo Biosciences, Inc. Modulation of stem cells using zinc finger proteins
US20040259258A1 (en) * 2001-12-07 2004-12-23 Kim Jin-Soo Regulation of prokaryotic gene expression with zinc finger proteins
KR20040065235A (ko) 2001-12-07 2004-07-21 주식회사 툴젠 키메라 단백질의 표현형질 스크리닝
US6899892B2 (en) * 2001-12-19 2005-05-31 Regents Of The University Of Minnesota Methods to reduce body fat
US7262054B2 (en) 2002-01-22 2007-08-28 Sangamo Biosciences, Inc. Zinc finger proteins for DNA binding and gene regulation in plants
CN100575485C (zh) 2002-01-23 2009-12-30 犹他大学研究基金会 使用锌指核酸酶的定向染色体诱变
WO2003080809A2 (en) * 2002-03-21 2003-10-02 Sangamo Biosciences, Inc. Methods and compositions for using zinc finger endonucleases to enhance homologous recombination
WO2003104414A2 (en) * 2002-06-11 2003-12-18 The Scripps Research Institute Artificial transcription factors
ATE405658T1 (de) 2002-07-26 2008-09-15 Basf Plant Science Gmbh Neue selektionsverfahren
EP2278018A3 (de) 2002-08-07 2012-01-04 BASF Plant Science GmbH Nukleinsäuren die für Proteine kodieren, die an abiotischer Stressantwort beteiligt sind
US7361635B2 (en) * 2002-08-29 2008-04-22 Sangamo Biosciences, Inc. Simultaneous modulation of multiple genes
AU2003298574B2 (en) 2002-09-05 2008-04-24 California Institute Of Technology Use of chimeric nucleases to stimulate gene targeting
EP2270166A3 (de) 2002-09-18 2011-08-10 Mendel Biotechnology, Inc. Polynukleotide und Polypeptide in Pflanzen
US20070178454A1 (en) * 2002-10-21 2007-08-02 Joung J K Context sensitive paralell optimization of zinc finger dna binding domains
AU2003304087A1 (en) * 2002-10-23 2004-11-26 The General Hospital Corporation Methods for producing zinc finger proteins that bind to extended dna target sequences
WO2004046387A1 (en) * 2002-11-15 2004-06-03 Sangamo Biosciences, Inc. Methods and compositions for analysis of regulatory sequences
US7696334B1 (en) * 2002-12-05 2010-04-13 Rosetta Genomics, Ltd. Bioinformatically detectable human herpesvirus 5 regulatory gene
US20060251643A1 (en) * 2002-12-09 2006-11-09 Toolgen, Inc. Regulatory zinc finger proteins
AU2003303589B2 (en) 2002-12-26 2008-04-24 Syngenta Participations Ag Cell proliferation-related polypeptides and uses therefor
US20070042433A1 (en) * 2003-03-26 2007-02-22 Jianxin Bao Neuregulin protein regulation of synaptic proteins
EP2194136A3 (de) 2003-04-15 2010-10-06 BASF Plant Science GmbH Nukleinsäuresequenzen aus Hefe, die für Proteine in Zusammenhang mit abiotischer Stressreaktion kodieren, sowie transgene Pflanzenzellen und Pflanzen mit erhöhter Umweltstressverträglichkeit
US8409861B2 (en) * 2003-08-08 2013-04-02 Sangamo Biosciences, Inc. Targeted deletion of cellular DNA sequences
US7888121B2 (en) * 2003-08-08 2011-02-15 Sangamo Biosciences, Inc. Methods and compositions for targeted cleavage and recombination
DK2927318T3 (da) 2003-08-08 2020-08-03 Sangamo Therapeutics Inc Fremgangsmåde og sammensætninger til målrettet spaltning og rekombination
US20120196370A1 (en) 2010-12-03 2012-08-02 Fyodor Urnov Methods and compositions for targeted genomic deletion
US11311574B2 (en) 2003-08-08 2022-04-26 Sangamo Therapeutics, Inc. Methods and compositions for targeted cleavage and recombination
US7219018B2 (en) * 2003-09-11 2007-05-15 Franco Vitaliano Quantum information processing elements and quantum information processing platforms using such elements
US7219017B2 (en) 2003-09-11 2007-05-15 Franco Vitaliano Quantum information processing elements and quantum information processing platforms using such elements
US7216038B2 (en) 2003-09-11 2007-05-08 Franco Vitaliano Quantum information processing elements and quantum information processing platforms using such elements
WO2005028630A2 (en) 2003-09-19 2005-03-31 Sangamo Biosciences, Inc. Engineered zinc finger proteins for regulation of gene expression
US7972854B2 (en) 2004-02-05 2011-07-05 Sangamo Biosciences, Inc. Methods and compositions for targeted cleavage and recombination
EP1732614B1 (de) * 2004-04-08 2008-12-24 Sangamo Biosciences Inc. Zusammensetzungen zur behandlung von neuropathischen und neurodegenerativen erkrankungen
CA2561565C (en) * 2004-04-08 2013-11-26 Sangamo Biosciences, Inc. Methods for repression of phospholamban gene and modulating cardiac contractility
AU2005287278B2 (en) 2004-09-16 2011-08-04 Sangamo Biosciences, Inc. Compositions and methods for protein production
CN101495507B (zh) 2004-09-24 2013-07-17 巴斯福植物科学有限公司 编码与非生物性胁迫反应相关的蛋白质的核酸序列和具有增加的环境胁迫抗性的植物细胞和植物
US7470777B2 (en) 2004-12-22 2008-12-30 Iowa State University Research Foundation, Inc. Compositions and methods related to modified retroviral vectors for restricted, site specific integration
CA2594572A1 (en) 2005-01-14 2006-07-20 University Of Guelph Nitrogen-regulated sugar sensing gene and protein and modulation thereof
CA2599004C (en) 2005-02-28 2015-05-26 Sangamo Biosciences, Inc. Anti-angiogenic methods and compositions
EP1913149A4 (de) 2005-07-26 2009-08-05 Sangamo Biosciences Inc Gezielte integration und expression exogener nukleinsäuresequenzen
BRPI0614367A2 (pt) 2005-08-12 2009-08-18 Basf Plant Science Gmbh célula de planta, planta, semente, molécula de ácido nucleico isolado, construto de ácido nucleico, vetor, célula hospedeira, proteìna relacionada a estresse isolada, métodos para produzir uma planta transgênica, para modificar toleráncia a estresse de uma planta, para detectar estresse ambiental em células de planta ou plantas, para triar células de planta ou plantas para toleráncia e/ou resistência aumentada a estresse ambiental, e para reproduzir células de planta ou plantas para toleráncia e/ou resistência aumentada a estresse ambiental, e, uso de um ácido nucleico
EP1929019A2 (de) 2005-09-08 2008-06-11 Chromatin, Inc. Mit minichromosomen modifizierte pflanzen
EP1963499A4 (de) 2005-11-28 2009-04-08 Scripps Research Inst Zinkfinger-bindungsdomänen für tnn
WO2007110314A2 (en) 2006-03-24 2007-10-04 Basf Plant Science Gmbh Proteins associated with abiotic stress response and homologs
WO2007136685A2 (en) * 2006-05-19 2007-11-29 Sangamo Biosciences, Inc. Methods and compositions for inactivation of dihydrofolate reductase
ATE462783T1 (de) * 2006-05-25 2010-04-15 Sangamo Biosciences Inc Variante foki-spaltungshälften-domänen
JP5551432B2 (ja) * 2006-05-25 2014-07-16 サンガモ バイオサイエンシーズ， インコーポレイテッド 遺伝子不活性化のための方法と組成物
BRPI0716395A2 (pt) 2006-08-10 2013-09-17 Basf Plant Science Gmbh mÉtodo para aumentar a resistÊncia contra a ferrugem da soja em plantas transgÊnicas e/ou cÉlulas vegetais, uso de pelo menos uma molÉcula de Ácido nuclÉico, planta ou cÉlula vegetal, vetor de expressço, e, màlecula de Ácido nuclÉico isolada.
ZA200900787B (en) 2006-08-11 2010-05-26 Dow Agrosciences Llc Zinc finger nuclease-mediated homologous recombination
EP2059600B1 (de) 2006-08-30 2014-04-02 BASF Plant Science GmbH Verfahren zur erhöhung der pathogenresistenz in transgenen pflanzen
CA2660861A1 (en) 2006-10-12 2008-04-17 Basf Plant Science Gmbh Method for increasing pathogen resistance in transgenic plants
US8344205B2 (en) 2006-10-13 2013-01-01 Basf Plant Science Gmbh Plants with increased yield
EP2089427B1 (de) * 2006-11-13 2014-07-30 Sangamo BioSciences, Inc. Auf eine stelle des humanen glucocorticoidrezeptors gerichtete zinkfingernuklease
WO2008067840A1 (en) 2006-12-08 2008-06-12 Swetree Technologies Ab Plants having improved growth characteristics and method for making the same
EP2412812B1 (de) 2006-12-14 2015-02-11 Dow AgroSciences LLC Optimierte nichtkanonische Zinkfingerproteine
CN101849016A (zh) 2007-02-19 2010-09-29 羸创德固赛有限责任公司 具有甲酰基-thf-合成酶和/或甘氨酸切割活性的棒状杆菌
CA2584934A1 (en) 2007-04-17 2008-10-17 University Of Guelph Nitrogen-regulated sugar sensing gene and protein and modulation thereof
WO2008133938A2 (en) 2007-04-26 2008-11-06 Sangamo Biosciences, Inc. Targeted integration into the ppp1r12c locus
US20100251416A1 (en) 2007-05-22 2010-09-30 Basf Plant Science Gmbh Plants with increased tolerance and/or resistance to environmental stress and increased biomass production
BRPI0812387A2 (pt) 2007-05-23 2014-11-04 Syngenta Participations Ag Macadores de polinucleotídeo
JP5770471B2 (ja) 2007-07-12 2015-08-26 サンガモ バイオサイエンシーズ， インコーポレイテッド α−１，６−フコシルトランスフェラーゼ（ＦＵＴ８）遺伝子発現を不活性化するための方法および組成物
CN101861393B (zh) 2007-09-18 2013-12-25 巴斯夫植物科学有限公司 产量提高的植物
MX2010003064A (es) 2007-09-21 2010-04-07 Basf Plant Science Gmbh Plantas con rendimiento aumentado.
WO2009042163A2 (en) * 2007-09-27 2009-04-02 Sangamo Biosciences, Inc. Rapid in vivo identification of biologically active nucleases
CA2937438C (en) 2007-09-27 2020-07-07 Dow Agrosciences Llc Engineered zinc finger proteins targeting 5-enolpyruvyl shikimate-3-phosphate synthase genes
US11235026B2 (en) 2007-09-27 2022-02-01 Sangamo Therapeutics, Inc. Methods and compositions for modulating PD1
US8563314B2 (en) 2007-09-27 2013-10-22 Sangamo Biosciences, Inc. Methods and compositions for modulating PD1
CA2703045C (en) 2007-10-25 2017-02-14 Sangamo Biosciences, Inc. Methods and compositions for targeted integration
BRPI0821748A2 (pt) 2007-12-19 2019-09-24 Basf Plant Science Gmbh método para produzir uma planta com rendimento aumentado, molécula isolada de ácido nucleico, construção de ácido nucleico, vetor, processo para produzir um polipeptídeo, polipeptídeo, anticorpo, núcleo de célula de planta, célula de planta, tecido de planta, material de propagação, semente, pólen, progênie, ou uma parte de planta, ou uma planta com rendimento aumento, processo para a indentificação de um composto, método para a produção de uma composição agrícola, composição, polipeptídeo ou molécula de ácido nucleico, uso dos ácidos nucléicos, e, método para a indentificação de uma planta com um rendimento aumentado
EP2770060A3 (de) 2007-12-28 2014-12-31 Swetree Technologies Ab Gehölzpflanzen mit verbesserten Wachstumseigenschaften und Verfahren zu ihrer Herstellung anhand von Transkriptionsfaktoren
AU2009218478A1 (en) 2008-02-27 2009-09-03 Basf Plant Science Gmbh Plants with increased yield
CA2720903C (en) 2008-04-14 2019-01-15 Sangamo Biosciences, Inc. Linear donor constructs for targeted integration
EP3851520A1 (de) 2008-04-30 2021-07-21 SanBio, Inc. Nervenregenerierende zellen mit veränderter dna-methylierung
WO2009137872A1 (en) * 2008-05-14 2009-11-19 Simons Haplomics Limited Methods and compositions for the treatment of cancer
EP2297318B1 (de) 2008-05-28 2018-05-23 Sangamo Therapeutics, Inc. Zusammensetzungen zum verknüpfen von dna-bindungsdomänen und spaltungsdomänen
EP2294191B1 (de) 2008-06-10 2016-09-28 Sangamo BioSciences, Inc. Verfahren und zusammensetzungen zur erzeugung von bax- und bak-mangel-zelllinien
CN102123778B (zh) * 2008-08-14 2014-10-29 李伟德 利用离心力的动态过滤装置
EP2352822A2 (de) 2008-08-19 2011-08-10 BASF Plant Science GmbH Pflanzen mit erhöhtem ertrag mittels steigerung oder erzeugung von einer oder mehreren aktivitäten in der pflanze oder einem teil dieser
WO2010021692A1 (en) 2008-08-22 2010-02-25 Sangamo Biosciences, Inc. Methods and compositions for targeted single-stranded cleavage and targeted integration
BRPI0919153A2 (pt) 2008-09-23 2019-05-07 Basf Plant Science Gmbh método para produzir uma planta com rendimento aumentado, molécula de ácido nucleico, construto de ácido nucleico, vetor, processo para produzir um polipeptídeo, poliptídeo, anticorpo, núcleo de célula de planta, célula de planta, tecido de planta, material de propagação, pólen, progênie, material coletado, ou uma planta, ou uma parte da planta, planta transgênica, processo para identificar um composto, método para a produção de uma composição agrícola, composição, uso de ácido nucleico, e, método para a identificação de uma planta com um rendimento aumentado, e para aumentar o rendimento de uma população de plantas
US20110252509A1 (en) 2008-10-23 2011-10-13 BASF Plant Sceince GmbH Method for Producing a Transgenic Cell with Increased Gamma-Aminobutyric Acid (Gaba) Content
WO2010046221A1 (en) 2008-10-23 2010-04-29 Basf Plant Science Gmbh Plants with increased yield (nue)
WO2010053518A2 (en) 2008-10-29 2010-05-14 Sangamo Biosciences, Inc. Methods and compositions for inactivating glutamine synthetase gene expression
CN102264906A (zh) 2008-11-03 2011-11-30 瑞典树木科技公司 植物材料、植物以及产生具有改变的木质素特性之植物的方法
US20110318830A1 (en) * 2008-11-12 2011-12-29 The Regents Of The University Of California Compositions and methods for re-programming and re-differentiating cells
US20110023151A1 (en) * 2008-12-04 2011-01-27 Sigma-Aldrich Co. Genome editing of abc transporters
US20110016543A1 (en) * 2008-12-04 2011-01-20 Sigma-Aldrich Co. Genomic editing of genes involved in inflammation
US20110016540A1 (en) * 2008-12-04 2011-01-20 Sigma-Aldrich Co. Genome editing of genes associated with trinucleotide repeat expansion disorders in animals
US20110023141A1 (en) * 2008-12-04 2011-01-27 Sigma-Aldrich Co. Genomic editing of genes involved with parkinson's disease
US20110023144A1 (en) * 2008-12-04 2011-01-27 Sigma-Aldrich Co. Genomic editing of genes involved in amyotrophyic lateral sclerosis disease
US20110023157A1 (en) * 2008-12-04 2011-01-27 Sigma-Aldrich Co. Equine genome editing with zinc finger nucleases
US20110023140A1 (en) * 2008-12-04 2011-01-27 Sigma-Aldrich Co. Rabbit genome editing with zinc finger nucleases
US20110023159A1 (en) * 2008-12-04 2011-01-27 Sigma-Aldrich Co. Ovine genome editing with zinc finger nucleases
US20110023154A1 (en) * 2008-12-04 2011-01-27 Sigma-Aldrich Co. Silkworm genome editing with zinc finger nucleases
US20110023158A1 (en) * 2008-12-04 2011-01-27 Sigma-Aldrich Co. Bovine genome editing with zinc finger nucleases
US20110016539A1 (en) * 2008-12-04 2011-01-20 Sigma-Aldrich Co. Genome editing of neurotransmission-related genes in animals
US20110023150A1 (en) * 2008-12-04 2011-01-27 Sigma-Aldrich Co. Genome editing of genes associated with schizophrenia in animals
US20110016541A1 (en) * 2008-12-04 2011-01-20 Sigma-Aldrich Co. Genome editing of sensory-related genes in animals
US20110016546A1 (en) * 2008-12-04 2011-01-20 Sigma-Aldrich Co. Porcine genome editing with zinc finger nucleases
US20110023143A1 (en) * 2008-12-04 2011-01-27 Sigma-Aldrich Co. Genomic editing of neurodevelopmental genes in animals
US20110016542A1 (en) * 2008-12-04 2011-01-20 Sigma-Aldrich Co. Canine genome editing with zinc finger nucleases
US20110030072A1 (en) * 2008-12-04 2011-02-03 Sigma-Aldrich Co. Genome editing of immunodeficiency genes in animals
US20110023147A1 (en) * 2008-12-04 2011-01-27 Sigma-Aldrich Co. Genomic editing of prion disorder-related genes in animals
US20110023146A1 (en) * 2008-12-04 2011-01-27 Sigma-Aldrich Co. Genomic editing of genes involved in secretase-associated disorders
US20110023145A1 (en) * 2008-12-04 2011-01-27 Sigma-Aldrich Co. Genomic editing of genes involved in autism spectrum disorders
US20110023139A1 (en) * 2008-12-04 2011-01-27 Sigma-Aldrich Co. Genomic editing of genes involved in cardiovascular disease
US20110023149A1 (en) * 2008-12-04 2011-01-27 Sigma-Aldrich Co. Genomic editing of genes involved in tumor suppression in animals
SG172760A1 (en) 2008-12-04 2011-08-29 Sangamo Biosciences Inc Genome editing in rats using zinc-finger nucleases
US20110023156A1 (en) * 2008-12-04 2011-01-27 Sigma-Aldrich Co. Feline genome editing with zinc finger nucleases
US20110023152A1 (en) * 2008-12-04 2011-01-27 Sigma-Aldrich Co. Genome editing of cognition related genes in animals
US20110023153A1 (en) * 2008-12-04 2011-01-27 Sigma-Aldrich Co. Genomic editing of genes involved in alzheimer's disease
US20110023148A1 (en) * 2008-12-04 2011-01-27 Sigma-Aldrich Co. Genome editing of addiction-related genes in animals
CN102333868B (zh) 2008-12-17 2015-01-07 陶氏益农公司 靶向整合入Zp15 基因座
EP2199399A1 (de) 2008-12-17 2010-06-23 BASF Plant Science GmbH Ketokarotinoidproduktion in Pflanzen
EP2393506B1 (de) 2009-02-04 2018-03-28 Sangamo Therapeutics, Inc. Verfahren und zusammensetzungen zur behandlung von nervenleiden
US11235062B2 (en) * 2009-03-06 2022-02-01 Metaqor Llc Dynamic bio-nanoparticle elements
US11096901B2 (en) 2009-03-06 2021-08-24 Metaqor Llc Dynamic bio-nanoparticle platforms
US8871905B2 (en) 2009-03-20 2014-10-28 Sangamo Biosciences, Inc. Modification of CXCR4 using engineered zinc finger proteins
JP6215533B2 (ja) 2009-04-09 2017-10-18 サンガモ セラピューティクス， インコーポレイテッド 幹細胞への標的組込み
US8772008B2 (en) 2009-05-18 2014-07-08 Sangamo Biosciences, Inc. Methods and compositions for increasing nuclease activity
EP2449135B1 (de) * 2009-06-30 2016-01-06 Sangamo BioSciences, Inc. Schnelles screening biologisch aktiver nukleasen und isolation nukleasemodifizierter zellen
EP2451837B1 (de) 2009-07-08 2015-03-25 Cellular Dynamics International, Inc. Modifizierte ips-zellen mit einer mutanten form des hiv-zelleintrittsgens
WO2011009801A1 (en) 2009-07-23 2011-01-27 Basf Plant Science Company Gmbh Plants with increased yield
JP5866283B2 (ja) 2009-07-28 2016-02-17 サンガモ バイオサイエンシーズ， インコーポレイテッド トリヌクレオチド反復疾患を治療するための方法および組成物
NZ598457A (en) * 2009-08-03 2014-06-27 Recombinetics Inc Methods and compositions for targeted gene modification
WO2011017293A2 (en) * 2009-08-03 2011-02-10 The General Hospital Corporation Engineering of zinc finger arrays by context-dependent assembly
CA2770312A1 (en) 2009-08-11 2011-02-17 Sangamo Biosciences, Inc. Organisms homozygous for targeted modification
JP5827233B2 (ja) 2009-10-22 2015-12-02 ダウ アグロサイエンシィズ エルエルシー 脂肪酸生合成に関与する植物遺伝子をターゲッティングする改変ジンクフィンガータンパク質
US8956828B2 (en) 2009-11-10 2015-02-17 Sangamo Biosciences, Inc. Targeted disruption of T cell receptor genes using engineered zinc finger protein nucleases
EP2501816A4 (de) 2009-11-17 2013-07-03 Basf Plant Science Co Gmbh Pflanzen mit erhöhtem ertrag
WO2011064736A1 (en) 2009-11-27 2011-06-03 Basf Plant Science Company Gmbh Optimized endonucleases and uses thereof
NZ601247A (en) 2010-01-22 2014-10-31 Dow Agrosciences Llc Targeted genomic alteration
AU2011213242B2 (en) 2010-02-08 2015-01-29 Sangamo Therapeutics, Inc. Engineered cleavage half-domains
WO2011100058A1 (en) 2010-02-09 2011-08-18 Sangamo Biosciences, Inc. Targeted genomic modification with partially single-stranded donor molecules
CA2796600C (en) 2010-04-26 2019-08-13 Sangamo Biosciences, Inc. Genome editing of a rosa locus using zinc-finger nucleases
US8772453B2 (en) 2010-05-03 2014-07-08 Sangamo Biosciences, Inc. Compositions for linking zinc finger modules
CA2798988C (en) 2010-05-17 2020-03-10 Sangamo Biosciences, Inc. Tal-effector (tale) dna-binding polypeptides and uses thereof
EP2596011B1 (de) 2010-07-21 2018-10-03 Sangamo Therapeutics, Inc. Verfahren und zusammensetzungen zur veränderung eines hla-locus
SG187075A1 (en) 2010-07-23 2013-03-28 Sigma Aldrich Co Llc Genome editing using targeting endonucleases and single-stranded nucleic acids
US9566352B2 (en) 2010-09-27 2017-02-14 Sangamo Biosciences, Inc. Methods and compositions for inhibiting viral entry into cells
WO2012051343A1 (en) 2010-10-12 2012-04-19 The Children's Hospital Of Philadelphia Methods and compositions for treating hemophilia b
WO2012092379A2 (en) 2010-12-29 2012-07-05 Sigma-Aldrich Co. Llc Cells having disrupted expression of proteins involved in adme and toxicology processes
US9267123B2 (en) 2011-01-05 2016-02-23 Sangamo Biosciences, Inc. Methods and compositions for gene correction
WO2012139045A1 (en) 2011-04-08 2012-10-11 Gilead Biologics, Inc. Methods and compositions for normalization of tumor vasculature by inhibition of loxl2
JP2014520533A (ja) 2011-06-30 2014-08-25 シグマ−アルドリッチ・カンパニー・リミテッド・ライアビリティ・カンパニー Ｃｍｐ−ｎ−アセチルノイラミン酸ヒドロキシラーゼおよび／または糖タンパク質アルファ−１，３−ガラクトシルトランスフェラーゼを欠損する細胞
AU2012284365B2 (en) 2011-07-15 2017-04-20 The General Hospital Corporation Methods of transcription activator like effector assembly
WO2013016446A2 (en) 2011-07-25 2013-01-31 Sangamo Biosciences, Inc. Methods and compositions for alteration of a cystic fibrosis transmembrane conductance regulator (cftr) gene
US9394545B2 (en) 2011-09-21 2016-07-19 Sangamo Biosciences, Inc. Methods and compositions for regulation of transgene expression
WO2013050318A1 (en) 2011-10-07 2013-04-11 Basf Plant Science Company Gmbh Method of producing plants having increased resistance to pathogens
US20140296129A1 (en) * 2011-10-11 2014-10-02 Aliophtha Ag Regulation of receptor expression through delivery of artificial transcription factors
CA2852955C (en) 2011-10-27 2021-02-16 Sangamo Biosciences, Inc. Methods and compositions for modification of the hprt locus
AU2012340213B2 (en) 2011-11-16 2017-12-07 Sangamo Therapeutics, Inc. Modified DNA-binding proteins and uses thereof
JP6262665B2 (ja) 2012-01-11 2018-01-17 シグマ−アルドリッチ・カンパニー、エルエルシー 単純な糖型を有する組換えタンパク質の産生
EP4218727A3 (de) 2012-01-27 2023-08-30 SanBio, Inc. Verfahren und zusammensetzungen zur modulation der angiogenese und vaskulogenese
US10570378B2 (en) 2012-02-28 2020-02-25 Sigma-Aldrich Co. Llc Targeted histone acetylation
BR112014021104B1 (pt) 2012-02-29 2023-03-28 Sangamo Biosciences, Inc Proteína de fusão de ocorrência não natural compreendendo um domínio de ligação de dna de dedo de zinco manipulado que se liga a um gene htt, seu uso, método in vitro de modificação da expressão de um gene htt em uma célula, e método de geração de um sistema modelo para o estudo da doença de huntington
JP6352250B2 (ja) 2012-05-02 2018-07-04 ダウ アグロサイエンシィズ エルエルシー リンゴ酸デヒドロゲナーゼの標的改変
AU2013259647B2 (en) 2012-05-07 2018-11-08 Corteva Agriscience Llc Methods and compositions for nuclease-mediated targeted integration of transgenes
EP3646880A1 (de) 2012-05-07 2020-05-06 Allergan, Inc. Verfahren zur behandlung von amd bei gegen eine anti-vegf-therapie unempfindlichen patienten
US9890364B2 (en) 2012-05-29 2018-02-13 The General Hospital Corporation TAL-Tet1 fusion proteins and methods of use thereof
EP3816281A1 (de) 2012-07-11 2021-05-05 Sangamo Therapeutics, Inc. Verfahren und zusammensetzungen zur behandlung von lysosomalen speicherkrankheiten
US10648001B2 (en) 2012-07-11 2020-05-12 Sangamo Therapeutics, Inc. Method of treating mucopolysaccharidosis type I or II
EP2872154B1 (de) 2012-07-11 2017-05-31 Sangamo BioSciences, Inc. Verfahren und zusammensetzungen zur freisetzung von biologischen wirkstoffen
US9650648B2 (en) 2012-08-29 2017-05-16 Sangamo Biosciences, Inc. Methods and compositions for treatment of a genetic condition
WO2014039513A2 (en) 2012-09-04 2014-03-13 The Trustees Of The University Of Pennsylvania Inhibition of diacylglycerol kinase to augment adoptive t cell transfer
UA118090C2 (uk) 2012-09-07 2018-11-26 ДАУ АГРОСАЙЄНСІЗ ЕлЕлСі Спосіб інтегрування послідовності нуклеїнової кислоти, що представляє інтерес, у ген fad2 у клітині сої та специфічний для локусу fad2 білок, що зв'язується, здатний індукувати спрямований розрив
UA119135C2 (uk) 2012-09-07 2019-05-10 ДАУ АГРОСАЙЄНСІЗ ЕлЕлСі Спосіб отримання трансгенної рослини
AU2013312538B2 (en) 2012-09-07 2019-01-24 Corteva Agriscience Llc FAD3 performance loci and corresponding target site specific binding proteins capable of inducing targeted breaks
EP3763810A3 (de) 2012-10-10 2021-07-14 Sangamo Therapeutics, Inc. T-zell-modifizierende verbindungen und verwendungen davon
EP3789405A1 (de) 2012-10-12 2021-03-10 The General Hospital Corporation Transkriptionsaktivator-like-effektor-lysinspezifische demethylase-1 (lsd1)-fusionsproteine
US9255250B2 (en) 2012-12-05 2016-02-09 Sangamo Bioscience, Inc. Isolated mouse or human cell having an exogenous transgene in an endogenous albumin gene
JP2016500268A (ja) 2012-12-13 2016-01-12 ダウ アグロサイエンシィズ エルエルシー トウモロコシにおける特定の遺伝子座に対する精密な遺伝子標的化
EP2946015B1 (de) 2013-01-16 2021-05-26 Emory University Cas9-nukleinsäurekomplexe und verwendungen dafür
AU2014214719B2 (en) 2013-02-07 2020-02-13 The General Hospital Corporation Tale transcriptional activators
JP5954808B2 (ja) 2013-02-14 2016-07-20 国立大学法人大阪大学 内在性ｄｎａ配列特異的結合分子を用いる特定ゲノム領域の単離方法
CA2901676C (en) 2013-02-25 2023-08-22 Sangamo Biosciences, Inc. Methods and compositions for enhancing nuclease-mediated gene disruption
KR102210322B1 (ko) 2013-03-15 2021-02-01 더 제너럴 하스피탈 코포레이션 Rna-안내 게놈 편집의 특이성을 증가시키기 위한 rna-안내 foki 뉴클레아제(rfn)의 용도
WO2014204578A1 (en) 2013-06-21 2014-12-24 The General Hospital Corporation Using rna-guided foki nucleases (rfns) to increase specificity for rna-guided genome editing
US10760064B2 (en) 2013-03-15 2020-09-01 The General Hospital Corporation RNA-guided targeting of genetic and epigenomic regulatory proteins to specific genomic loci
US9937207B2 (en) 2013-03-21 2018-04-10 Sangamo Therapeutics, Inc. Targeted disruption of T cell receptor genes using talens
EP3679785A3 (de) 2013-04-05 2020-09-16 Dow AgroSciences LLC Verfahren und zusammensetzungen zur integration einer exogenen sequenz in das genom von pflanzen
CA2910427C (en) 2013-05-10 2024-02-20 Sangamo Biosciences, Inc. Delivery methods and compositions for nuclease-mediated genome engineering
CA2910489A1 (en) 2013-05-15 2014-11-20 Sangamo Biosciences, Inc. Methods and compositions for treatment of a genetic condition
US9567609B2 (en) 2013-08-28 2017-02-14 Sangamo Biosciences, Inc. Compositions for linking DNA-binding domains and cleavage domains
US10117899B2 (en) 2013-10-17 2018-11-06 Sangamo Therapeutics, Inc. Delivery methods and compositions for nuclease-mediated genome engineering in hematopoietic stem cells
EP3441468B1 (de) 2013-10-17 2021-05-19 Sangamo Therapeutics, Inc. Freisetzungsverfahren und zusammensetzungen für nukleasevermitteltes genomengineering
RU2016120636A (ru) 2013-11-04 2017-12-06 ДАУ АГРОСАЙЕНСИЗ ЭлЭлСи Оптимальные локусы сои
TWI721478B (zh) 2013-11-04 2021-03-11 美商陶氏農業科學公司 最適玉米基因座（二）
US10233465B2 (en) 2013-11-04 2019-03-19 Dow Agrosciences Llc Optimal soybean loci
EP3065540B1 (de) 2013-11-04 2021-12-15 Corteva Agriscience LLC Optimale maispflanzen
LT3066201T (lt) 2013-11-07 2018-08-10 Editas Medicine, Inc. Su crispr susiję būdai ir kompozicijos su valdančiomis grnr
AU2014346424B2 (en) 2013-11-11 2020-09-17 Sangamo Therapeutics, Inc. Methods and compositions for treating Huntington's Disease
LT3068881T (lt) 2013-11-13 2019-08-12 Children`S Medical Center Corporation Geno raiškos reguliavimas, tarpininkaujant nukleazei
CN105874071B (zh) 2013-12-09 2020-04-14 桑格摩生物科学股份有限公司 基因组工程化的方法和组合物
WO2015117081A2 (en) 2014-02-03 2015-08-06 Sangamo Biosciences, Inc. Methods and compositions for treatment of a beta thalessemia
CA2939541C (en) 2014-02-14 2022-11-08 Symvivo Corporation Hybrid proteins and uses thereof
AU2015218576B2 (en) 2014-02-24 2020-02-27 Sangamo Therapeutics, Inc. Methods and compositions for nuclease-mediated targeted integration
EP3736325A1 (de) 2014-03-04 2020-11-11 Sigma Aldrich Co. LLC Virenresistente zellen und deren verwendung
WO2015143046A2 (en) 2014-03-18 2015-09-24 Sangamo Biosciences, Inc. Methods and compositions for regulation of zinc finger protein expression
EP3134728B1 (de) 2014-04-22 2023-03-29 Q-State Biosciences, Inc. Optogenetische analyse von verbindungen
US9522936B2 (en) 2014-04-24 2016-12-20 Sangamo Biosciences, Inc. Engineered transcription activator like effector (TALE) proteins
CA2947035A1 (en) 2014-05-08 2015-11-12 Sangamo Biosciences, Inc. Methods and compositions for treating huntington's disease
EP3142707A4 (de) 2014-05-13 2018-02-21 Sangamo Therapeutics, Inc. Verfahren und zusammensetzungen zur vorbeugung oder behandlung einer krankheit
CN107002094A (zh) 2014-05-30 2017-08-01 斯坦福大学托管董事会 用于治疗潜伏病毒感染的组合物和方法
EP3151846A4 (de) 2014-06-05 2017-12-27 Sangamo BioSciences, Inc. Verfahren und zusammensetzungen zur nukleasekonstruktion
AR100874A1 (es) 2014-06-16 2016-11-09 Consejo Nac De Investig Científicas Y Técnicas (Conicet) Genes quiméricos y proteínas de resistencia oxidativa, y plantas transgénicas que incluyen los mismos
JP6784601B2 (ja) 2014-06-23 2020-11-11 ザ ジェネラル ホスピタル コーポレイション シークエンシングによって評価されるゲノムワイドでバイアスのないＤＳＢの同定（ＧＵＩＤＥ−Ｓｅｑ）
WO2016005449A1 (en) 2014-07-08 2016-01-14 Vib Vzw Means and methods to increase plant yield
EP3169778B1 (de) 2014-07-14 2023-10-25 Washington State University Nanos-knock-out zur abladierung von keimbahnzellen
US11278572B2 (en) 2014-07-18 2022-03-22 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Reducing CXCR4 expression and/or function to enhance engraftment of hematopoietic stem cells
US9816074B2 (en) 2014-07-25 2017-11-14 Sangamo Therapeutics, Inc. Methods and compositions for modulating nuclease-mediated genome engineering in hematopoietic stem cells
WO2016014837A1 (en) 2014-07-25 2016-01-28 Sangamo Biosciences, Inc. Gene editing for hiv gene therapy
WO2016019144A2 (en) 2014-07-30 2016-02-04 Sangamo Biosciences, Inc. Gene correction of scid-related genes in hematopoietic stem and progenitor cells
SG11201702134RA (en) 2014-09-16 2017-04-27 Sangamo Therapeutics Inc Methods and compositions for nuclease-mediated genome engineering and correction in hematopoietic stem cells
EP3201340B1 (de) 2014-10-01 2020-12-02 The General Hospital Corporation Verfahren zur erhöhung der effizienz von nucleaseinduzierter homologiegerichteter reparatur
US10889834B2 (en) 2014-12-15 2021-01-12 Sangamo Therapeutics, Inc. Methods and compositions for enhancing targeted transgene integration
WO2016118726A2 (en) 2015-01-21 2016-07-28 Sangamo Biosciences, Inc. Methods and compositions for identification of highly specific nucleases
BR112017016789A2 (pt) 2015-02-11 2018-05-08 Basf Se métodos para produzir uma planta transgênica, para controlar a vegetação indesejada e para o cultivo da planta, molécula de ácido nucleico, construção de ácido nucleico, vetor, polipeptídeo hppd mutado, núcleo de célula vegetal, núcleo de célula vegetal transgênica, planta transgênica, uso do ácido nucleico, combinação útil, processo para a preparação de uma combinação útil e uso de uma combinação útil
US10048275B2 (en) 2015-03-13 2018-08-14 Q-State Biosciences, Inc. Cardiotoxicity screening methods
US20180094243A1 (en) 2015-04-03 2018-04-05 Dana-Farber Cancer Institute, Inc. Composition and methods of genome editing of b-cells
US10179918B2 (en) 2015-05-07 2019-01-15 Sangamo Therapeutics, Inc. Methods and compositions for increasing transgene activity
WO2016183298A2 (en) 2015-05-12 2016-11-17 Sangamo Biosciences, Inc. Nuclease-mediated regulation of gene expression
CA2986583A1 (en) 2015-05-21 2016-11-24 Q-State Biosciences, Inc. Optogenetics microscope
US10117911B2 (en) 2015-05-29 2018-11-06 Agenovir Corporation Compositions and methods to treat herpes simplex virus infections
GB2543873A (en) 2015-05-29 2017-05-03 Agenovir Corp Compositions and methods for cell targeted HPV treatment
WO2016193945A2 (en) 2015-06-05 2016-12-08 Novartis Ag Methods and compositions for diagnosing, treating, and monitoring treatment of shank3 deficiency associated disorders
US9957501B2 (en) 2015-06-18 2018-05-01 Sangamo Therapeutics, Inc. Nuclease-mediated regulation of gene expression
WO2017011519A1 (en) 2015-07-13 2017-01-19 Sangamo Biosciences, Inc. Delivery methods and compositions for nuclease-mediated genome engineering
ES2981381T3 (es) 2015-08-06 2024-10-08 Univ Missouri Porcinos resistentes al virus del síndrome respiratorio y reproductivo porcino (PRRSV) y células que tienen genes CD163 modificados
US9926546B2 (en) 2015-08-28 2018-03-27 The General Hospital Corporation Engineered CRISPR-Cas9 nucleases
US9512446B1 (en) 2015-08-28 2016-12-06 The General Hospital Corporation Engineered CRISPR-Cas9 nucleases
CN108350453A (zh) 2015-09-11 2018-07-31 通用医疗公司 核酸酶dsb的完全查询和测序(find-seq)
CA2998500A1 (en) 2015-09-23 2017-03-30 Sangamo Therapeutics, Inc. Htt repressors and uses thereof
JP2018529353A (ja) 2015-09-30 2018-10-11 ザ ジェネラル ホスピタル コーポレイション 配列決定法による切断事象の包括的生体外報告（ＣＩＲＣＬＥ−ｓｅｑ）
WO2017091512A1 (en) 2015-11-23 2017-06-01 Sangamo Biosciences, Inc. Methods and compositions for engineering immunity
US11352631B2 (en) 2015-12-18 2022-06-07 Sangamo Therapeutics, Inc. Targeted disruption of the T cell receptor
KR20180088911A (ko) 2015-12-18 2018-08-07 상가모 테라퓨틱스, 인코포레이티드 Mhc 세포 수용체의 표적화된 붕괴
BR112018014288A2 (pt) 2016-01-15 2018-12-18 Univ Minnesota métodos e composições para o tratamento de doença neurológica
WO2017136049A1 (en) 2016-02-02 2017-08-10 Sangamo Biosciences, Inc. Compositions for linking dna-binding domains and cleavage domains
US11421218B2 (en) 2016-03-23 2022-08-23 Dana-Farber Cancer Institute, Inc. Methods for enhancing the efficiency of gene editing
EP3484870B1 (de) 2016-07-13 2022-11-16 Vertex Pharmaceuticals Incorporated Verfahren, zusammensetzungen und kits zur erhöhung der genomeditierungseffizienz
JP2019520844A (ja) 2016-07-21 2019-07-25 マックスサイト インコーポレーティッド ゲノムｄｎａを改変するための方法および組成物
EP3490556A4 (de) 2016-07-27 2020-04-15 Case Western Reserve University Verbindungen und verfahren zur förderung der myelinisierung
EP3497213B1 (de) 2016-08-09 2023-10-18 Vib Vzw Cellulosesynthaseinhibitoren und mutante pflanzen
CR20190098A (es) 2016-08-24 2019-04-30 Sangamo Therapeutics Inc Regulación de la expresión génica usando nucleasas modificadas
EP3504327B1 (de) 2016-08-24 2021-10-06 Sangamo Therapeutics, Inc. Manipulierte zielspezifische nukleasen
EP3509645A4 (de) 2016-09-07 2020-06-17 Sangamo Therapeutics, Inc. Modulation von lebergenen
MX2019003768A (es) 2016-10-03 2019-06-24 Juno Therapeutics Inc Moleculas de enlace especificas de hpv.
EP3757120B8 (de) 2016-10-04 2022-06-15 Precision Biosciences, Inc. Co-stimulierende domänen zur verwendung bei genetisch veränderten zellen
KR102662249B1 (ko) 2016-10-14 2024-05-03 더 제너럴 하스피탈 코포레이션 후성적으로 조절되는 부위-특이적 뉴클레아제
IL266047B1 (en) 2016-10-20 2024-10-01 Sangamo Therapeutics Inc Methods and preparations for the treatment of Fabry disease
CA3041668A1 (en) 2016-10-31 2018-05-03 Sangamo Therapeutics, Inc. Gene correction of scid-related genes in hematopoietic stem and progenitor cells
BR112019010014A2 (pt) 2016-12-01 2019-08-20 Sangamo Therapeutics Inc moduladores de tau e métodos e composições para entrega dos mesmos
CA3046199A1 (en) 2016-12-08 2018-06-14 Case Western Reserve University Methods and compositions for enhancing functional myelin production
WO2018140478A1 (en) 2017-01-24 2018-08-02 Sigma-Aldrich Co. Llc Viral resistant cells and culture systems
SG11201906948UA (en) 2017-04-20 2019-08-27 Univ Oregon Health & Science Human gene correction
US11820728B2 (en) 2017-04-28 2023-11-21 Acuitas Therapeutics, Inc. Carbonyl lipids and lipid nanoparticle formulations for delivery of nucleic acids
CN110869497A (zh) 2017-05-03 2020-03-06 桑格摩生物治疗股份有限公司 修饰囊性纤维化跨膜传导调节蛋白（cftr）基因的方法和组合物
EP4029943A1 (de) 2017-05-08 2022-07-20 Precision Biosciences, Inc. Nukleinsäuremoleküle, die einen manipulierten antigenrezeptor und ein hemmendes nukleinsäuremolekül codieren, und verfahren zur verwendung davon
EP3630970A4 (de) 2017-05-25 2020-12-30 The General Hospital Corporation Basiseditoren mit verbesserter präzision und spezifität
US11512287B2 (en) 2017-06-16 2022-11-29 Sangamo Therapeutics, Inc. Targeted disruption of T cell and/or HLA receptors
AU2018292526A1 (en) 2017-06-30 2020-01-16 Precision Biosciences, Inc. Genetically-modified T cells comprising a modified intron in the T cell receptor alpha gene
WO2019070856A1 (en) 2017-10-03 2019-04-11 Precision Biosciences, Inc. MODIFIED EPIDERMAL GROWTH FACTOR RECEPTOR PEPTIDES FOR USE IN GENETICALLY MODIFIED CELLS
EP4215543A3 (de) 2017-10-03 2023-10-11 Juno Therapeutics, Inc. Hpv-spezifische bindungsmoleküle
US20200299658A1 (en) 2017-11-01 2020-09-24 Precision Biosciences, Inc. Engineered nucleases that target human and canine factor viii genes as a treatment for hemophilia a
JP2021502085A (ja) 2017-11-09 2021-01-28 サンガモ セラピューティクス， インコーポレイテッド サイトカイン誘導性ｓｈ２含有タンパク質（ｃｉｓｈ）遺伝子の遺伝子改変
MX2020005561A (es) 2017-12-01 2020-10-12 Encoded Therapeutics Inc Proteinas modificadas de union a adn.
IL276080B2 (en) 2018-01-17 2023-10-01 Vertex Pharma DNA-PK suppressor compounds, UTP-containing preparations and their uses
JP7483612B2 (ja) 2018-01-17 2024-05-15 バーテックス ファーマシューティカルズ インコーポレイテッド ゲノム編集効率を増加するためのキノキサリノン化合物、組成物、方法、およびキット
US12121524B2 (en) 2018-01-17 2024-10-22 Vertex Pharmaceuticals Incorporated DNA-PK inhibitors
JP7275152B2 (ja) 2018-02-08 2023-05-17 サンガモ セラピューティクス， インコーポレイテッド 操作された標的特異的なヌクレアーゼ
US20210017249A1 (en) 2018-04-05 2021-01-21 Juno Therapeutics, Inc. Methods of producing cells expressing a recombinant receptor and related compositions
WO2019195486A1 (en) 2018-04-05 2019-10-10 Juno Therapeutics, Inc. T cell receptors and engineered cells expressing same
SG11202009446TA (en) 2018-04-05 2020-10-29 Juno Therapeutics Inc T cells expressing a recombinant receptor, related polynucleotides and methods
CN112313246A (zh) 2018-04-18 2021-02-02 桑格摩生物治疗股份有限公司 用于调节亨廷顿蛋白(htt)的锌指蛋白组合物
US11690921B2 (en) 2018-05-18 2023-07-04 Sangamo Therapeutics, Inc. Delivery of target specific nucleases
CN112166185A (zh) 2018-05-23 2021-01-01 新加坡国立大学 用于t细胞恶性肿瘤的免疫治疗的cd2表面表达和嵌合抗原受体表达的阻断
CN108802357B (zh) * 2018-06-27 2021-03-30 中南民族大学 一种用于免疫印迹分析的生物发光探针及其应用
SG11202101801RA (en) 2018-08-23 2021-03-30 Sangamo Therapeutics Inc Engineered target specific base editors
KR20210060533A (ko) 2018-09-18 2021-05-26 상가모 테라퓨틱스, 인코포레이티드 프로그램화된 세포 사멸 1 (pd1) 특이적 뉴클레아제
US20220090047A1 (en) 2018-12-21 2022-03-24 Precision Biosciences, Inc. Genetic modification of the hydroxyacid oxidase 1 gene for treatment of primary hyperoxaluria
DK3908568T3 (da) 2019-01-11 2024-08-26 Acuitas Therapeutics Inc Lipider til lipidnanopartikellevering af aktivstoffer
EP3917571A4 (de) 2019-01-31 2022-10-12 Agency For Science, Technology And Research Cnx/erp57-inhibitor zur verwendung bei der behandlung oder prävention von krebs
US11946040B2 (en) 2019-02-04 2024-04-02 The General Hospital Corporation Adenine DNA base editor variants with reduced off-target RNA editing
WO2020162978A1 (en) 2019-02-06 2020-08-13 Sangamo Therapeutics, Inc. Method for the treatment of mucopolysaccharidosis type i
BR112021019448A2 (pt) 2019-04-02 2021-11-30 Sangamo Therapeutics Inc Métodos para o tratamento de beta-talassemia
KR20240122580A (ko) 2019-04-03 2024-08-12 프리시젼 바이오사이언시스 인코포레이티드 마이크로RNA-적응 shRNA(shRNAmiR)를 포함하는 유전자-변형 면역 세포
US20220204994A1 (en) 2019-04-05 2022-06-30 Precision Biosciences, Inc. Methods of preparing populations of genetically-modified immune cells
SG11202111443SA (en) 2019-04-23 2021-11-29 Sangamo Therapeutics Inc Modulators of chromosome 9 open reading frame 72 gene expression and uses thereof
SG11202111360YA (en) 2019-05-01 2021-11-29 Juno Therapeutics Inc Cells expressing a recombinant receptor from a modified tgfbr2 locus, related polynucleotides and methods
AU2020265749A1 (en) 2019-05-01 2022-01-06 Juno Therapeutics, Inc. Cells expressing a chimeric receptor from a modified CD247 locus, related polynucleotides and methods
CN113993891A (zh) 2019-06-13 2022-01-28 艾洛基治疗公司 抗talen抗体及其用途
WO2021016608A1 (en) 2019-07-25 2021-01-28 Precision Biosciences, Inc. Compositions and methods for sequential stacking of nucleic acid sequences into a genomic locus
CA3148179A1 (en) 2019-08-20 2021-02-25 Bruce J. Mccreedy Jr. Lymphodepletion dosing regimens for cellular immunotherapies
WO2021035170A1 (en) 2019-08-21 2021-02-25 Precision Biosciences, Inc. Compositions and methods for tcr reprogramming using fusion proteins
JP2022551286A (ja) 2019-10-02 2022-12-08 サンガモ セラピューティクス， インコーポレイテッド α－シヌクレイン発現を抑制するためのジンクフィンガータンパク質転写因子
WO2021067864A1 (en) 2019-10-02 2021-04-08 Sangamo Therapeutics, Inc. Zinc finger protein transcription factors for treatment of prion disease
EP3812472B1 (de) 2019-10-21 2022-11-23 Albert-Ludwigs-Universität Freiburg In-vitro-test zum profilieren der off-target-aktivität eines oder mehrerer zielspezifischer programmierbarer nukleasen in zellen (abnoba-seq)
US20220411479A1 (en) 2019-10-30 2022-12-29 Precision Biosciences, Inc. Cd20 chimeric antigen receptors and methods of use for immunotherapy
CN115279419A (zh) 2019-11-01 2022-11-01 美商圣加莫治疗股份有限公司 用于基因组工程的组合物和方法
US20210130828A1 (en) 2019-11-01 2021-05-06 Sangamo Therapeutics, Inc. Gin recombinase variants
US20230036065A1 (en) 2019-12-06 2023-02-02 Precision Biosciences, Inc. Methods for cancer immunotherapy
AU2021209699A1 (en) 2020-01-22 2022-07-21 Sangamo Therapeutics, Inc. Zinc finger protein transcription factors for repressing tau expression
WO2021158915A1 (en) 2020-02-06 2021-08-12 Precision Biosciences, Inc. Recombinant adeno-associated virus compositions and methods for producing and using the same
CN115697044A (zh) 2020-03-31 2023-02-03 艾洛生物系统有限公司 西瓜和其他葫芦科中内源罗汉果苷途径基因的调控
JP2023525513A (ja) 2020-05-06 2023-06-16 セレクティス ソシエテ アノニム 細胞ゲノムにおける外因性配列の標的化挿入のための方法
CN115715203A (zh) 2020-05-06 2023-02-24 塞勒克提斯公司 对细胞进行基因修饰以递送治疗性蛋白质的方法
WO2021231259A1 (en) 2020-05-11 2021-11-18 Precision Biosciences, Inc. Self-limiting viral vectors encoding nucleases
WO2021231661A2 (en) 2020-05-13 2021-11-18 Juno Therapeutics, Inc. Process for producing donor-batched cells expressing a recombinant receptor
EP4171616A1 (de) 2020-06-26 2023-05-03 Juno Therapeutics GmbH Manipulierte t-zellen zur bedingten expression eines rekombinanten rezeptors, zugehörige polynukleotide und verfahren
BR112023000327A2 (pt) 2020-07-16 2023-01-31 Acuitas Therapeutics Inc Lipídeos catiônicos para o uso em nanopartículas lipídicas
EP4192875A1 (de) 2020-08-10 2023-06-14 Precision BioSciences, Inc. Antikörper und fragmente spezifisch für b-zellreifungsantigen und verwendungen davon
WO2022046760A2 (en) 2020-08-25 2022-03-03 Kite Pharma, Inc. T cells with improved functionality
AU2021350099A1 (en) 2020-09-25 2023-04-27 Sangamo Therapeutics, Inc. Zinc finger fusion proteins for nucleobase editing
IL301795A (en) 2020-10-02 2023-05-01 Sangamo Therapeutics Inc Novel zinc finger protein transcription factors for repressing alpha-synuclein expression
WO2022076547A1 (en) 2020-10-07 2022-04-14 Precision Biosciences, Inc. Lipid nanoparticle compositions
US20240060079A1 (en) 2020-10-23 2024-02-22 Elo Life Systems Methods for producing vanilla plants with improved flavor and agronomic production
CN116802203A (zh) 2020-11-04 2023-09-22 朱诺治疗学股份有限公司 从经修饰的恒定cd3免疫球蛋白超家族链基因座表达嵌合受体的细胞、相关多核苷酸和方法
MX2023005665A (es) 2020-11-16 2023-08-01 Pig Improvement Co Uk Ltd Animales resistentes a la influenza a que tienen genes de anp32 editados.
WO2022165111A1 (en) 2021-01-28 2022-08-04 Precision Biosciences, Inc. Modulation of tgf beta signaling in genetically-modified eukaryotic cells
US20240141311A1 (en) 2021-04-22 2024-05-02 North Carolina State University Compositions and methods for generating male sterile plants
JP2024533311A (ja) 2021-09-08 2024-09-12 フラッグシップ パイオニアリング イノベーションズ シックス，エルエルシー ゲノムを調節するための方法及び組成物
WO2023064872A1 (en) 2021-10-14 2023-04-20 Precision Biosciences, Inc. Combinations of anti-bcma car t cells and gamma secretase inhibitors
IL312244A (en) 2021-10-19 2024-06-01 Prec Biosciences Inc Gene editing methods to treat alpha-1 antitrypsin (AAT) deficiency
WO2023081900A1 (en) 2021-11-08 2023-05-11 Juno Therapeutics, Inc. Engineered t cells expressing a recombinant t cell receptor (tcr) and related systems and methods
TW202328201A (zh) 2021-11-09 2023-07-16 美商安進公司 產生抗體肽軛合物的方法
WO2023091910A1 (en) 2021-11-16 2023-05-25 Precision Biosciences, Inc. Methods for cancer immunotherapy
WO2023105244A1 (en) 2021-12-10 2023-06-15 Pig Improvement Company Uk Limited Editing tmprss2/4 for disease resistance in livestock
IL313486A (en) 2021-12-16 2024-08-01 Acuitas Therapeutics Inc Lipids for use in lipid nanoparticle formulations
IL313758A (en) 2021-12-22 2024-08-01 Sangamo Therapeutics Inc Novel zinc finger fusion proteins for nuclear base editing
WO2023131616A1 (en) 2022-01-05 2023-07-13 Vib Vzw Means and methods to increase abiotic stress tolerance in plants
WO2023131637A1 (en) 2022-01-06 2023-07-13 Vib Vzw Improved silage grasses
WO2023144199A1 (en) 2022-01-26 2023-08-03 Vib Vzw Plants having reduced levels of bitter taste metabolites
WO2023168397A1 (en) 2022-03-04 2023-09-07 Sigma-Aldrich Co. Llc Metabolic selection via the asparagine biosynthesis pathway
WO2024013514A2 (en) 2022-07-15 2024-01-18 Pig Improvement Company Uk Limited Gene edited livestock animals having coronavirus resistance
WO2024073686A1 (en) 2022-09-30 2024-04-04 Sigma-Aldrich Co. Llc Metabolic selection via the serine biosynthesis pathway
WO2024073692A1 (en) 2022-09-30 2024-04-04 Sigma-Aldrich Co. Llc Metabolic selection via the glycine-formate biosynthesis pathway
WO2024100604A1 (en) 2022-11-09 2024-05-16 Juno Therapeutics Gmbh Methods for manufacturing engineered immune cells
WO2024161021A1 (en) 2023-02-03 2024-08-08 Juno Therapeutics Gmbh Methods for non-viral manufacturing of engineered immune cells
WO2024216118A1 (en) 2023-04-14 2024-10-17 Precision Biosciences, Inc. Muscle-specific expression cassettes
WO2024216116A1 (en) 2023-04-14 2024-10-17 Precision Biosciences, Inc. Muscle-specific expression cassettes

Family Cites Families (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3410650A1 (de) 1984-03-23 1985-10-03 Kernforschungsanlage Jülich GmbH, 5170 Jülich Mit mikroorganismen bewachsene poroese anorganische traeger, verfahren zur immobilisierung von mikroorganismen und dafuer geeignete traegerkoerper
US5455170A (en) 1986-08-22 1995-10-03 Hoffmann-La Roche Inc. Mutated thermostable nucleic acid polymerase enzyme from Thermus species Z05
US5317090A (en) 1987-12-16 1994-05-31 Institut Pasteur Steroid/thyroid hormone receptor-related gene, which is inappropriately expressed in human hepatocellular carcinoma, and which is a retinoic acid receptor
US5324819A (en) 1988-04-08 1994-06-28 Stryker Corporation Osteogenic proteins
US5340739A (en) 1988-07-13 1994-08-23 Brigham & Women's Hospital Hematopoietic cell specific transcriptional regulatory elements of serglycin and uses thereof
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
EP0451206A4 (en) 1988-12-23 1992-07-22 The Salk Institute For Biological Studies Receptor transcription-repression activity compositions and methods
US5198346A (en) 1989-01-06 1993-03-30 Protein Engineering Corp. Generation and selection of novel DNA-binding proteins and polypeptides
US5096815A (en) 1989-01-06 1992-03-17 Protein Engineering Corporation Generation and selection of novel dna-binding proteins and polypeptides
US4990607A (en) 1989-03-14 1991-02-05 The Rockefeller University Alteration of gene expression in plants
DE69032324T2 (de) 1989-03-17 1998-10-08 The Salk Institute For Biological Studies, La Jolla, Calif. Zusammensetzung und testverfahren eines elementes als antwort auf ein hormon
JP3393867B2 (ja) 1989-11-13 2003-04-07 マサチユーセツツ・インステイテユート・オブ・テクノロジー ウィルムス腫瘍遺伝子の位置決定と特徴付け
US5578482A (en) 1990-05-25 1996-11-26 Georgetown University Ligand growth factors that bind to the erbB-2 receptor protein and induce cellular responses
AU8498091A (en) 1990-08-02 1992-03-02 Regents Of The University Of Colorado, The Systematic polypeptide evolution by reverse translation
US5639592A (en) 1990-09-21 1997-06-17 The Salk Institute For Biological Studies Functional antagonism between proto-oncoprotein c-Jun and hormone receptors
US5348864A (en) 1991-01-25 1994-09-20 E. R. Squibb & Sons, Inc. Mouse vav proto-oncogene DNA and protein sequences
DE69230142T2 (de) 1991-05-15 2000-03-09 Cambridge Antibody Technology Ltd. Verfahren zur herstellung von spezifischen bindungspaargliedern
US5324818A (en) 1991-08-21 1994-06-28 The Regents Of The University Of Michigan Proteins useful in the regulation of κB-containing genes
US5243041A (en) 1991-08-22 1993-09-07 Fernandez Pol Jose A DNA vector with isolated CDNA gene encoding metallopanstimulin
US5302519A (en) 1991-09-09 1994-04-12 Fred Hutchinson Cancer Research Center Method of producing a Mad polypeptide
US5270170A (en) 1991-10-16 1993-12-14 Affymax Technologies N.V. Peptide library and screening method
US5756448A (en) * 1992-02-26 1998-05-26 The General Hospital Corporation Constitute activator of retinoid (CAR) receptor polypeptides
US5792640A (en) 1992-04-03 1998-08-11 The Johns Hopkins University General method to clone hybrid restriction endonucleases using lig gene
US5436150A (en) 1992-04-03 1995-07-25 The Johns Hopkins University Functional domains in flavobacterium okeanokoities (foki) restriction endonuclease
US5916794A (en) 1992-04-03 1999-06-29 Johns Hopkins University Methods for inactivating target DNA and for detecting conformational change in a nucleic acid
US5356802A (en) 1992-04-03 1994-10-18 The Johns Hopkins University Functional domains in flavobacterium okeanokoites (FokI) restriction endonuclease
US5487994A (en) 1992-04-03 1996-01-30 The Johns Hopkins University Insertion and deletion mutants of FokI restriction endonuclease
US5324638A (en) 1992-05-13 1994-06-28 Sloan-Kettering Institute For Cancer Research Brain transcription factor, nucleic acids encoding same and uses thereof
AU8124694A (en) 1993-10-29 1995-05-22 Affymax Technologies N.V. In vitro peptide and antibody display libraries
US6140466A (en) * 1994-01-18 2000-10-31 The Scripps Research Institute Zinc finger protein derivatives and methods therefor
JP4012243B2 (ja) 1994-01-18 2007-11-21 ザ スクリップス リサーチ インスティチュート 亜鉛フィンガータンパク質誘導体およびそのための方法
US5605793A (en) 1994-02-17 1997-02-25 Affymax Technologies N.V. Methods for in vitro recombination
WO1995032225A1 (en) * 1994-05-23 1995-11-30 The Salk Institute For Biological Studies Method for site-specific integration of nucleic acids and related products
WO1996006110A1 (en) 1994-08-18 1996-02-29 Gilman, Michael, Z. Composite dna-binding proteins and materials and methods relating thereto
ATE407205T1 (de) 1994-08-20 2008-09-15 Gendaq Ltd Verbesserung in bezug auf bindungsproteine bei der erkennung von dna
GB9824544D0 (en) 1998-11-09 1999-01-06 Medical Res Council Screening system
DE4435919C1 (de) 1994-10-07 1995-12-07 Deutsches Krebsforsch Zinkfinger-DNA, -Protein und ihre Verwendung
US5871902A (en) 1994-12-09 1999-02-16 The Gene Pool, Inc. Sequence-specific detection of nucleic acid hybrids using a DNA-binding molecule or assembly capable of discriminating perfect hybrids from non-perfect hybrids
US5702914A (en) 1994-12-21 1997-12-30 The Salk Institute For Biological Studies Use of reporter genes for retinoid receptor screening assays having novel retinoid-associated response elements
JP3817739B2 (ja) 1994-12-29 2006-09-06 マサチューセッツ・インスティテュート・オブ・テクノロジー キメラｄｎａ結合性タンパク質
US5789538A (en) 1995-02-03 1998-08-04 Massachusetts Institute Of Technology Zinc finger proteins with high affinity new DNA binding specificities
WO1996032475A2 (en) 1995-04-12 1996-10-17 University Of Washington Methods for preparing dna-binding proteins
EP1295952A3 (de) 1996-01-23 2003-07-09 The Board of Trustees of The Leland Stanford Junior University Verfahren zum screenen für transdominate Effectorpeptiden und RNS molekülen
FR2752734B1 (fr) 1996-09-02 1998-11-06 Cird Galderma Utilisation de retinoides pour la preparation d'un medicament destine a traiter les affections liees a une surexpression de vegf
US5939538A (en) 1996-10-25 1999-08-17 Immusol Incorporated Methods and compositions for inhibiting HIV infection of cells by cleaving HIV co-receptor RNA
DE19718249A1 (de) 1997-04-30 1998-11-05 Basf Ag Myc-bindende Zinkfinger-Proteine, ihre Herstellung und ihre Verwendung
GB9710809D0 (en) 1997-05-23 1997-07-23 Medical Res Council Nucleic acid binding proteins
GB9710807D0 (en) 1997-05-23 1997-07-23 Medical Res Council Nucleic acid binding proteins
CA2318402A1 (en) 1998-01-15 1999-07-22 Ariad Gene Therapeutics, Inc. Regulation of biological events using multimeric chimeric proteins
US5972615A (en) 1998-01-21 1999-10-26 Urocor, Inc. Biomarkers and targets for diagnosis, prognosis and management of prostate disease
US6410248B1 (en) 1998-01-30 2002-06-25 Massachusetts Institute Of Technology General strategy for selecting high-affinity zinc finger proteins for diverse DNA target sites
DE69933856D1 (de) 1998-02-13 2006-12-14 Koester Hubert Verwendung von ribozymen zur bestimmung der funktion von genen
WO1999042474A2 (en) 1998-02-20 1999-08-26 Genome Dynamics, Inc. Method for designing dna-binding proteins of the zinc-finger class
WO1999045132A1 (en) 1998-03-02 1999-09-10 Massachusetts Institute Of Technology Poly zinc finger proteins with improved linkers
ATE336578T1 (de) 1998-03-17 2006-09-15 Gendaq Ltd Nukleinsäurebindungsproteine
US6140081A (en) 1998-10-16 2000-10-31 The Scripps Research Institute Zinc finger binding domains for GNN
US6453242B1 (en) 1999-01-12 2002-09-17 Sangamo Biosciences, Inc. Selection of sites for targeting by zinc finger proteins and methods of designing zinc finger proteins to bind to preselected sites
US6534261B1 (en) 1999-01-12 2003-03-18 Sangamo Biosciences, Inc. Regulation of endogenous gene expression in cells using zinc finger proteins

Also Published As

Publication number Publication date
CA2196419C (en) 2007-08-21
JPH10504461A (ja) 1998-05-06
AU698152B2 (en) 1998-10-22
USRE42211E1 (en) 2011-03-08
US6013453A (en) 2000-01-11
WO1996006166A1 (en) 1996-02-29
USRE42150E1 (en) 2011-02-15
USRE45721E1 (en) 2015-10-06
EP2022856A2 (de) 2009-02-11
EP0781331B1 (de) 2008-09-03
EP0781331A1 (de) 1997-07-02
ATE524545T1 (de) 2011-09-15
EP2022856A3 (de) 2009-04-01
US6007988A (en) 1999-12-28
EP2022856B1 (de) 2011-09-14
JP4118327B2 (ja) 2008-07-16
CA2196419A1 (en) 1996-02-29
USRE39229E1 (en) 2006-08-08
JP4942637B2 (ja) 2012-05-30
JP2008119007A (ja) 2008-05-29
AU3229195A (en) 1996-03-14
USRE45795E1 (en) 2015-11-10
DE69535829D1 (de) 2008-10-16

Similar Documents

Publication Publication Date Title
ATE407205T1 (de) Verbesserung in bezug auf bindungsproteine bei der erkennung von dna
CA2282497A1 (en) In vitro peptide or protein expression library
DK216589A (da) Dna sekvenser, rekombinante dna molekyler samt fremgangsmaader til fresmtilling af oploeselige t4-proteiner
GR3030811T3 (en) Proteins produced by human lymphocytes, dna sequence coding these proteins, and pharmaceutical and biological uses thereof
EP0770129A4 (de) Derivate von zinkfingerproteinen und methoden
ATE309536T1 (de) Methoden zur verwendung von randomisierten zinkfingerprotein-bibliotheken zur identifizierung von genfunktionen
ATE388165T1 (de) Menschliches cnp-gen und vorläuferprotein
DE69530542D1 (de) Kassensystem zur Identifizierung und Registrierung von Artikeln
NO20020276D0 (no) In vitro seleksjon og valgfri identifikasjon av polypeptider ved bruk av fast-fase b¶rere
DE68914664D1 (de) Gereinigte ubiquitin-hydrolase, diese kodierende dns-sequenzen und ihre verwendung zur gewinnung von polypeptiden.
NO971059D0 (no) Modifiserte human-C3-proteiner
DE69332798D1 (de) Ikaros: ein regulatorisches gen bei der t-zell differenzierung
ID24914A (id) Protein-protein pengikat peptida b-amiloid dan polinukleotida yang menuliskan kode protein tersebut
FR2755144B1 (fr) Fragments d'anticorps a chaine unique anti-p53 et utilisation
DE69130845D1 (de) HLA-DR Antigen-Gen, dessen Nukleotidsequenz und Verwendung
EP0738277A4 (de) Proteine, die an Retinoblastem - Proteine binden und ihre kodierenden DNA - Sequenzen
NO905561D0 (no) Proteiner og nukleinsyrer.
ES2191033T3 (es) Alergenos recombinantes de cladosporium herbarum.
PT676413E (pt) Proteina de ligacao a interferoes alfa/beta, sua preparacao e utilizacao
BR9408061A (pt) Sequência de dna codificando carboxipeptidase b pancreática de suiínos
AU2161699A (en) Peptides and nucleic acids derived from (eisenia foetida) and the use thereof
EP0846165A4 (de) Neue cystein-protease von filariiden nematoden, nuklöeinsäuremoleküle und ihre verwendungen
ATE393224T1 (de) Nukleinsäuresequenzen von hyperplasien und tumoren der schilddrüse
HUP9802289A2 (hu) Limfocita specifikus interferon szabályozó faktor (LSIRF) polipeptideket kódoló gének
BR9814866A (pt) Uso de oligÈmeros de ácido poliamida nucléicopara produzir uma resposta biológica

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties