Nothing Special   »   [go: up one dir, main page]

ATE335051T1 - Energieübertragungsfarbstoffe mit verbesserter fluoreszenz - Google Patents

Energieübertragungsfarbstoffe mit verbesserter fluoreszenz

Info

Publication number
ATE335051T1
ATE335051T1 AT99201120T AT99201120T ATE335051T1 AT E335051 T1 ATE335051 T1 AT E335051T1 AT 99201120 T AT99201120 T AT 99201120T AT 99201120 T AT99201120 T AT 99201120T AT E335051 T1 ATE335051 T1 AT E335051T1
Authority
AT
Austria
Prior art keywords
dye
energy transfer
donor
linkers
acceptor
Prior art date
Application number
AT99201120T
Other languages
English (en)
Inventor
Linda G Lee
Sandra L Spurgeon
Barnett Rosenblum
Original Assignee
Applera Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/642,330 external-priority patent/US5863727A/en
Application filed by Applera Corp filed Critical Applera Corp
Application granted granted Critical
Publication of ATE335051T1 publication Critical patent/ATE335051T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B11/00—Diaryl- or thriarylmethane dyes
    • C09B11/04—Diaryl- or thriarylmethane dyes derived from triarylmethanes, i.e. central C-atom is substituted by amino, cyano, alkyl
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B11/00—Diaryl- or thriarylmethane dyes
    • C09B11/04—Diaryl- or thriarylmethane dyes derived from triarylmethanes, i.e. central C-atom is substituted by amino, cyano, alkyl
    • C09B11/06—Hydroxy derivatives of triarylmethanes in which at least one OH group is bound to an aryl nucleus and their ethers or esters
    • C09B11/08—Phthaleins; Phenolphthaleins; Fluorescein
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B11/00—Diaryl- or thriarylmethane dyes
    • C09B11/04—Diaryl- or thriarylmethane dyes derived from triarylmethanes, i.e. central C-atom is substituted by amino, cyano, alkyl
    • C09B11/10—Amino derivatives of triarylmethanes
    • C09B11/24—Phthaleins containing amino groups ; Phthalanes; Fluoranes; Phthalides; Rhodamine dyes; Phthaleins having heterocyclic aryl rings; Lactone or lactame forms of triarylmethane dyes
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/02—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups
    • C09B23/08—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups more than three >CH- groups, e.g. polycarbocyanines
    • C09B23/083—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups more than three >CH- groups, e.g. polycarbocyanines five >CH- groups
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B69/00—Dyes not provided for by a single group of this subclass
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Luminescent Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Coloring (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
AT99201120T 1996-05-03 1997-05-02 Energieübertragungsfarbstoffe mit verbesserter fluoreszenz ATE335051T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/642,330 US5863727A (en) 1996-05-03 1996-05-03 Energy transfer dyes with enhanced fluorescence
US08/726,462 US5800996A (en) 1996-05-03 1996-10-04 Energy transfer dyes with enchanced fluorescence

Publications (1)

Publication Number Publication Date
ATE335051T1 true ATE335051T1 (de) 2006-08-15

Family

ID=27093992

Family Applications (2)

Application Number Title Priority Date Filing Date
AT99201120T ATE335051T1 (de) 1996-05-03 1997-05-02 Energieübertragungsfarbstoffe mit verbesserter fluoreszenz
AT97303039T ATE187752T1 (de) 1996-05-03 1997-05-02 Energieübertragungsfarbstoffe mit verbesserter fluoreszenz

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT97303039T ATE187752T1 (de) 1996-05-03 1997-05-02 Energieübertragungsfarbstoffe mit verbesserter fluoreszenz

Country Status (6)

Country Link
US (1) US5800996A (de)
EP (2) EP0805190B1 (de)
JP (8) JP3090626B2 (de)
AT (2) ATE335051T1 (de)
CA (1) CA2203494C (de)
DE (2) DE69736434T2 (de)

Families Citing this family (341)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6723556B1 (en) * 1982-12-02 2004-04-20 Cornell Research Foundation, Inc. Nucleic acid encoding a fragment of bovine luteinizing hormone/chorionic gonadotropin receptor
US5935522A (en) * 1990-06-04 1999-08-10 University Of Utah Research Foundation On-line DNA analysis system with rapid thermal cycling
US6787304B1 (en) 1994-12-28 2004-09-07 Georgetown University Fluorometric assay for detecting nucleic acid cleavage
US20030165908A1 (en) * 1994-12-30 2003-09-04 Georgetown University Fluorometric assay for detecting nucleic acid cleavage
US5800996A (en) * 1996-05-03 1998-09-01 The Perkin Elmer Corporation Energy transfer dyes with enchanced fluorescence
US5863727A (en) * 1996-05-03 1999-01-26 The Perkin-Elmer Corporation Energy transfer dyes with enhanced fluorescence
US5847162A (en) * 1996-06-27 1998-12-08 The Perkin Elmer Corporation 4, 7-Dichlororhodamine dyes
US5945526A (en) * 1996-05-03 1999-08-31 Perkin-Elmer Corporation Energy transfer dyes with enhanced fluorescence
US7388092B2 (en) * 1996-05-03 2008-06-17 Applera Corporation Oligonucleotides and analogs labeled with energy transfer dyes
US7825237B2 (en) * 1996-05-03 2010-11-02 Applied Biosystems, Llc Oligonucleotides and analogs labeled with energy transfer dyes
ES2304573T3 (es) * 1996-06-04 2008-10-16 University Of Utah Research Foundation Recipiente para llevar a cabo y controlar procesos biologicos.
CA2658290C (en) * 1996-06-04 2012-04-10 University Of Utah Research Foundation Monitoring hybridization during pcr using fluorescent dye specific to double-stranded dna
US5804386A (en) * 1997-01-15 1998-09-08 Incyte Pharmaceuticals, Inc. Sets of labeled energy transfer fluorescent primers and their use in multi component analysis
DE69825601T2 (de) 1997-02-12 2005-04-28 Chan, Eugene Y, Brookline Verfahren zur analyse von polymeren
US6265193B1 (en) 1997-03-12 2001-07-24 Pe Corporation (Ny) DNA polymerases having improved labeled nucleotide incorporation properties
WO1999002544A1 (fr) * 1997-07-11 1999-01-21 The Institute Of Physical And Chemical Research Composes possedant une fonction de transfert d'energie et procede de sequencage des bases d'adn a l'aide de ces composes
US7745142B2 (en) 1997-09-15 2010-06-29 Molecular Devices Corporation Molecular modification assays
US6130101A (en) * 1997-09-23 2000-10-10 Molecular Probes, Inc. Sulfonated xanthene derivatives
WO1999019514A1 (en) * 1997-10-09 1999-04-22 Transgenomic, Inc. Modifying double stranded dna to enhance separations by matched ion polynucleotide chromatography
US6485901B1 (en) 1997-10-27 2002-11-26 Boston Probes, Inc. Methods, kits and compositions pertaining to linear beacons
AU1366299A (en) 1997-10-27 1999-05-17 Boston Probes, Inc. Methods, kits and compositions pertaining to pna molecular beacons
US5936087A (en) * 1997-11-25 1999-08-10 The Perkin-Elmer Corporation Dibenzorhodamine dyes
US6583168B1 (en) * 1997-11-25 2003-06-24 Applera Corporation Sulfonated diarylrhodamine dyes
CA2319490A1 (en) * 1998-02-03 1999-08-05 Amersham Pharmacia Biotech Inc. Energy transfer dyes
WO1999049293A2 (en) 1998-03-24 1999-09-30 Boston Probes, Inc. Methods, kits and compositions pertaining to detection complexes
DE19824535A1 (de) 1998-06-03 1999-12-09 Roche Diagnostics Gmbh Neue Rhodamin-Derivate und deren Verwendung
GB2341189B (en) * 1998-08-31 2001-06-13 Amersham Pharm Biotech Inc Energy transfer dyes
US6379957B1 (en) * 1998-09-21 2002-04-30 Leslie A. Johnston-Dow Methods for HIV sequencing and genotyping
DE19850593A1 (de) * 1998-11-03 2000-05-04 Biochip Technologies Gmbh Verfahren zum Nachweis von Hybridisierungsereignissen bei DNA
AU2180200A (en) 1998-12-14 2000-07-03 Li-Cor Inc. A heterogeneous assay for pyrophosphate detection
US6635419B1 (en) 1999-02-16 2003-10-21 Applera Corporation Polynucleotide sequencing method
US6399392B1 (en) 1999-04-23 2002-06-04 Molecular Probes, Inc. Xanthene dyes and their application as luminescence quenching compounds
US6248884B1 (en) 1999-06-03 2001-06-19 The Perkin-Elmer Corporation Extended rhodamine compounds useful as fluorescent labels
US6358684B1 (en) 1999-08-27 2002-03-19 Pe Corporation UV excitable fluorescent energy transfer dyes
US6982146B1 (en) * 1999-08-30 2006-01-03 The United States Of America As Represented By The Department Of Health And Human Services High speed parallel molecular nucleic acid sequencing
US6372907B1 (en) * 1999-11-03 2002-04-16 Apptera Corporation Water-soluble rhodamine dye peptide conjugates
US6191278B1 (en) * 1999-11-03 2001-02-20 Pe Corporation Water-soluble rhodamine dyes and conjugates thereof
US6716994B1 (en) 2000-01-04 2004-04-06 Applera Corporation Mobility-Modifying Cyanine Dyes
US6221604B1 (en) 2000-02-07 2001-04-24 Pe Corporation Electron-deficient nitrogen heterocycle-substituted fluorescein dyes
JP4589588B2 (ja) * 2000-02-28 2010-12-01 哲雄 長野 長寿命励起型蛍光を用いる測定方法
DE10012326A1 (de) * 2000-03-14 2001-09-20 Philips Corp Intellectual Pty Flüssigkristall-Farbbildschirm
US6346384B1 (en) 2000-03-27 2002-02-12 Dade Behring Inc. Real-time monitoring of PCR using LOCI
US6465644B1 (en) 2000-05-02 2002-10-15 Applera Corporation Sulfonated [8,9] benzophenoxazine dyes and the use of their labelled conjugates
US6936702B2 (en) * 2000-06-07 2005-08-30 Li-Cor, Inc. Charge-switch nucleotides
US6869764B2 (en) 2000-06-07 2005-03-22 L--Cor, Inc. Nucleic acid sequencing using charge-switch nucleotides
CA2425663C (en) * 2000-10-11 2009-12-29 Applera Corporation Fluorescent nucleobase conjugates having anionic linkers
US6448407B1 (en) 2000-11-01 2002-09-10 Pe Corporation (Ny) Atropisomers of asymmetric xanthene fluorescent dyes and methods of DNA sequencing and fragment analysis
WO2002044425A2 (en) 2000-12-01 2002-06-06 Visigen Biotechnologies, Inc. Enzymatic nucleic acid synthesis: compositions and methods for altering monomer incorporation fidelity
US7129346B2 (en) * 2000-12-20 2006-10-31 Molecular Probes, Inc. Crown ether derivatives
US6962992B2 (en) 2000-12-20 2005-11-08 Molecullar Probes, Inc. Crown ether derivatives
US7579463B2 (en) 2000-12-20 2009-08-25 Life Technologies Corporation Crown ether derivatives
JP4647187B2 (ja) * 2001-04-02 2011-03-09 セルメド バイオサイエンシズ インコーポレイテッド ハロゲン化ローダミン誘導体およびその適用
WO2002095356A2 (en) 2001-05-21 2002-11-28 Aclara Biosciences, Inc. Methods and compositions for analyzing proteins
US20020187508A1 (en) * 2001-06-08 2002-12-12 Wong Gordon G. Methods and products for analyzing nucleic acids using nick translation
US6887690B2 (en) 2001-06-22 2005-05-03 Pe Corporation Dye-labeled ribonucleotide triphosphates
US20050042629A1 (en) 2002-09-13 2005-02-24 Applera Corporation Thermus scotoductus nucleic acid polymerases
US20050118589A1 (en) 2001-11-21 2005-06-02 Vann Charles S. Digital array
AU2002346498A1 (en) 2001-11-30 2003-06-17 Applera Corporation Thermus brockianus nucleic acid polymerases
US7026166B2 (en) * 2002-01-22 2006-04-11 Chiron Corporation Fluorogenic dyes
US7166478B2 (en) * 2002-03-12 2007-01-23 Enzo Life Sciences, Inc., C/O Enzo Biochem, Inc. Labeling reagents and labeled targets, target labeling processes and other processes for using same in nucleic acid determinations and analyses
US7091348B2 (en) * 2002-07-01 2006-08-15 Guava Technologies, Inc. Fluorescent dyes, energy transfer couples and methods
US7524974B2 (en) * 2002-07-08 2009-04-28 Tetsuo Nagano Fluorescent probe
EP1389638A1 (de) * 2002-08-06 2004-02-18 Roche Diagnostics GmbH Verbesserte Proben für FRET
EP1403382A3 (de) * 2002-08-06 2004-05-06 Roche Diagnostics GmbH Verbesserte Proben für FRET
JP2006500588A (ja) * 2002-09-25 2006-01-05 アマシャム・バイオサイエンス・コーポレイション 複数のドナー及びアクセプターを有する蛍光標識試薬
EP1405920A3 (de) * 2002-10-02 2004-04-14 Roche Diagnostics GmbH Verbesserte FRET Methode
US7407747B2 (en) * 2002-10-15 2008-08-05 Applera Corporation Method for drying dye-terminator sequencing reagents
AU2003275553A1 (en) * 2002-10-16 2004-05-25 Daiichi Pure Chemicals Co., Ltd. Reagents for the measurement of peroxynitrites
AU2003291677A1 (en) * 2002-10-30 2004-05-25 Pointilliste, Inc. Methods for producing polypeptide-tagged collections and capture systems containing the tagged polypeptides
US7704756B2 (en) * 2003-01-21 2010-04-27 Novartis Vaccines And Diagnostics, Inc. Fluorogenic dyes
US20040241748A1 (en) * 2003-02-10 2004-12-02 Dana Ault-Riche Self-assembling arrays and uses thereof
US7696245B2 (en) * 2003-03-28 2010-04-13 Sekisui Medical Co., Ltd. Fluorescent probe for zinc
US20050250214A1 (en) * 2004-05-05 2005-11-10 Gee Kyle R Zinc binding compounds and their method of use
US8445702B2 (en) * 2003-05-05 2013-05-21 Life Technologies Corporation Zinc binding compounds and their method of use
WO2004101709A1 (en) 2003-05-09 2004-11-25 Applera Corporation Phenyl xanthene dyes
WO2004101708A1 (en) * 2003-05-09 2004-11-25 Applera Corporation Fluorescent polymeric materials containing lipid soluble rhodamine dyes
US7727752B2 (en) 2003-07-29 2010-06-01 Life Technologies Corporation Kinase and phosphatase assays
US7271265B2 (en) 2003-08-11 2007-09-18 Invitrogen Corporation Cyanine compounds and their application as quenching compounds
US20060029948A1 (en) * 2003-09-19 2006-02-09 Gary Lim Sealing cover and dye compatibility selection
US7570443B2 (en) 2003-09-19 2009-08-04 Applied Biosystems, Llc Optical camera alignment
US7417726B2 (en) * 2003-09-19 2008-08-26 Applied Biosystems Inc. Normalization of data using controls
WO2005051967A2 (en) * 2003-11-19 2005-06-09 Allelogic Biosciences Corp. Oligonucleotides labeled with a plurality of fluorophores
EP1538154B1 (de) * 2003-11-20 2008-12-31 Exiqon A/S Löscher-Zusammensetzung mit Anthraquinon
US7776529B2 (en) 2003-12-05 2010-08-17 Life Technologies Corporation Methine-substituted cyanine dye compounds
EP1720944B1 (de) * 2003-12-05 2013-07-17 Life Technologies Corporation Cyanin farbstoffverbindungen
GB0329161D0 (en) * 2003-12-16 2004-01-21 Precisense As Reagant for detecting an analyte
JP4127204B2 (ja) * 2003-12-17 2008-07-30 セイコーエプソン株式会社 液晶表示装置の製造方法
JP2005194244A (ja) * 2004-01-09 2005-07-21 Shigenobu Yano 亜鉛イオン蛍光センサー
WO2005071096A2 (en) 2004-01-21 2005-08-04 Molecular Probes, Inc. Derivatives of cephalosporin and clavulanic acid for detecting beta-lacamase in a sample
WO2005073409A2 (en) * 2004-01-26 2005-08-11 Applera Corporation Methods, compositions, and kits for amplifying and sequencing polynucleotides
US7344701B2 (en) 2004-02-03 2008-03-18 Biosearch Technologies, Inc. Xanthene dyes
US20050186606A1 (en) * 2004-02-11 2005-08-25 Schroeder Benjamin G. Methods and compositions for detecting nucleic acids
JP2007529758A (ja) * 2004-03-19 2007-10-25 ユー．エス． ジェノミクス， インコーポレイテッド 単一分子の検出のための組成物および方法
EP1740100B8 (de) * 2004-04-13 2017-01-25 Biosearch Technologies, Inc. Xanthen-farbstoffe
US20050255485A1 (en) * 2004-05-14 2005-11-17 Livak Kenneth J Detection of gene duplications
US20080103053A1 (en) * 2005-11-22 2008-05-01 Helicos Biosciences Corporation Methods and compositions for sequencing a nucleic acid
JP5435864B2 (ja) 2004-05-28 2014-03-05 アシュラジェン インコーポレイテッド マイクロｒｎａに関与する方法および組成物
EP1766089A1 (de) * 2004-06-30 2007-03-28 Applera Corporation Analogsondenkomplexe
WO2006023231A2 (en) 2004-07-27 2006-03-02 Molecular Probes, Inc. Fluorescent metal ion indicators with large stokes shift
WO2006034387A1 (en) 2004-09-21 2006-03-30 Applera Corporation TWO-COLOR REAL-TIME/END-POINT QUANTITATION OF MICRORNAS (miRNAs)
EP2322616A1 (de) 2004-11-12 2011-05-18 Asuragen, Inc. Verfahren und Zusammensetzungen, die miRNAs und miRNA-inhibitorischen Molekülen verbunden sind
US20060292586A1 (en) * 2004-12-17 2006-12-28 Schroth Gary P ID-tag complexes, arrays, and methods of use thereof
US20060166238A1 (en) * 2004-12-22 2006-07-27 Ramsing Niels B Probes, libraries and kits for analysis of mixtures of nucleic acids and methods for constructing the same
US20060228726A1 (en) * 2005-01-06 2006-10-12 Martin Patrick K Polypeptides having nucleic acid binding activity and compositions and methods for nucleic acid amplification
EP1838144B1 (de) 2005-01-07 2016-08-31 Oregon State University Verfahren zur auslösung einer rna-interferenz
WO2006099537A2 (en) 2005-03-15 2006-09-21 Applera Corporation The use of antibody-surrogate antigen systems for detection of analytes
EP1886145A2 (de) * 2005-05-03 2008-02-13 Applera Corporation Fluoreszenznachweissystem und farbstoffsatz zur verwendung damit
WO2006124816A1 (en) 2005-05-11 2006-11-23 Molecular Probes, Inc. Fluorescent chemical compounds having high selectivity for double stranded dna, and methods for their use
US8357801B2 (en) 2005-05-24 2013-01-22 Enzo Life Sciences, Inc. Labeling of target molecules, identification of organelles and other applications, novel compositions, methods and kits
US8362250B2 (en) 2005-05-24 2013-01-29 Enzo Biochem, Inc. Fluorescent dyes and compounds, methods and kits useful for identifying specific organelles and regions in cells of interest
US7569695B2 (en) * 2005-05-24 2009-08-04 Enzo Life Sciences, Inc. Dyes for the detection or quantification of desirable target molecules
US7737281B2 (en) * 2005-05-24 2010-06-15 Enzo Life Sciences, Inc. C/O Enzo Biochem, Inc. Purine based fluorescent dyes
JP5331476B2 (ja) 2005-06-15 2013-10-30 カリダ・ジェノミックス・インコーポレイテッド 遺伝子解析および化学解析用の単分子アレイ
US20070087360A1 (en) * 2005-06-20 2007-04-19 Boyd Victoria L Methods and compositions for detecting nucleotides
US7817273B2 (en) * 2005-06-30 2010-10-19 Life Technologies Corporation Two-dimensional spectral imaging system
US7663750B2 (en) * 2005-06-30 2010-02-16 Applied Biosystems, Llc Two-dimensional spectral imaging system
JP4963015B2 (ja) * 2005-07-28 2012-06-27 学校法人日本大学 ヌクレオチド誘導体及びその利用
EP2660482B1 (de) * 2005-08-22 2019-08-07 Life Technologies Corporation Vorrichtung, System und Verfahren unter Verwendung von nichtmischbaren Flüssigkeiten mit unterschiedlichen Volumen
US20070134685A1 (en) * 2005-09-06 2007-06-14 Invitrogen Corporation Control of chemical modification
US20070059713A1 (en) * 2005-09-09 2007-03-15 Lee Jun E SSB-DNA polymerase fusion proteins
ES2371088T3 (es) * 2005-10-05 2011-12-27 F. Hoffmann-La Roche Ag Transferencia de energía no fluorescente.
AU2007249635B2 (en) 2005-10-07 2012-05-31 Complete Genomics, Inc. High throughput genome sequencing on DNA arrays
EP2546360A1 (de) 2005-10-07 2013-01-16 Callida Genomics, Inc. Selbstangeordnete einzelne Molekülarrays und Verwendungen davon
US8703734B2 (en) 2005-12-12 2014-04-22 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Nanoprobes for detection or modification of molecules
JP2009519041A (ja) * 2005-12-12 2009-05-14 アメリカ合衆国 核酸配列決定のためのプローブおよび使用方法
US7521577B2 (en) * 2006-01-12 2009-04-21 Molecular Probes, Inc. Heavy metal binding compounds and their method of use
SG10201405158QA (en) 2006-02-24 2014-10-30 Callida Genomics Inc High throughput genome sequencing on dna arrays
WO2007106690A2 (en) 2006-03-15 2007-09-20 Siemens Healthcare Diagnostics Inc. Degenerate nucleobase analogs
EP2029781A4 (de) 2006-05-26 2010-06-30 Althea Technologies Inc Biochemische analyse partitionierter zellen
US7910302B2 (en) 2006-10-27 2011-03-22 Complete Genomics, Inc. Efficient arrays of amplified polynucleotides
WO2008070375A2 (en) 2006-11-09 2008-06-12 Complete Genomics, Inc. Selection of dna adaptor orientation
US20080131878A1 (en) * 2006-12-05 2008-06-05 Asuragen, Inc. Compositions and Methods for the Detection of Small RNA
AU2007333106A1 (en) * 2006-12-08 2008-06-19 Asuragen, Inc. miR-20 regulated genes and pathways as targets for therapeutic intervention
US8586743B2 (en) 2007-01-30 2013-11-19 Life Technologies Corporation Labeling reagents and methods of their use
US11940413B2 (en) 2007-02-05 2024-03-26 IsoPlexis Corporation Methods and devices for sequencing nucleic acids in smaller batches
NZ580374A (en) 2007-04-04 2012-06-29 Netbio Inc Plastic microfluidic separation and detection platforms
US20080274458A1 (en) * 2007-05-01 2008-11-06 Latham Gary J Nucleic acid quantitation methods
US8513451B2 (en) * 2007-05-30 2013-08-20 Hee Chol Kang Fluorescent phospholipase A2 indicators
US7816135B2 (en) 2007-07-05 2010-10-19 Becton, Dickinson And Company Method of analyzing lymphocytes
US8361714B2 (en) 2007-09-14 2013-01-29 Asuragen, Inc. Micrornas differentially expressed in cervical cancer and uses thereof
WO2009067632A1 (en) * 2007-11-20 2009-05-28 Applied Biosystems Inc. Method of sequencing nucleic acids using elaborated nucleotide phosphorothiolate compounds
WO2009067628A1 (en) 2007-11-20 2009-05-28 Applied Biosystems Inc. Reversible di-nucleotide terminator sequencing
US8071562B2 (en) 2007-12-01 2011-12-06 Mirna Therapeutics, Inc. MiR-124 regulated genes and pathways as targets for therapeutic intervention
WO2009097368A2 (en) 2008-01-28 2009-08-06 Complete Genomics, Inc. Methods and compositions for efficient base calling in sequencing reactions
US20090246762A1 (en) * 2008-03-31 2009-10-01 Applera Corporation, Applied Biosystems Group Nucleic acid terminators incorporating a cationic moiety and methods for their use
US8258111B2 (en) 2008-05-08 2012-09-04 The Johns Hopkins University Compositions and methods related to miRNA modulation of neovascularization or angiogenesis
CN104263816B (zh) 2008-05-16 2018-10-19 生命技术公司 用于测量细胞增殖的双标记法
US9334281B2 (en) * 2008-09-08 2016-05-10 Enzo Life Sciences, Inc. Fluorochromes for organelle tracing and multi-color imaging
US9250249B2 (en) 2008-09-08 2016-02-02 Enzo Biochem, Inc. Autophagy and phospholipidosis pathway assays
US20100159452A1 (en) * 2008-12-22 2010-06-24 Roche Molecular Systems, Inc. Method For Detecting a Target Nucleic Acid in a Sample
EP2432895A2 (de) 2009-05-22 2012-03-28 Asuragen, INC. Mirna-biomarker für erkrankungen der prostata
US9550985B2 (en) 2009-06-15 2017-01-24 Netbio, Inc. Methods for forensic DNA quantitation
US8735074B2 (en) 2009-08-28 2014-05-27 Asuragen, Inc. MiRNA biomarkers of lung disease
US9133343B2 (en) * 2009-11-30 2015-09-15 Enzo Biochem, Inc. Dyes and compositions, and processes for using same in analysis of protein aggregation and other applications
KR101590220B1 (ko) 2009-12-31 2016-01-29 벤타나 메디컬 시스템즈, 인코포레이티드 유일 특이적 핵산 프로브 제조 방법
DK2539355T3 (da) 2010-02-26 2017-01-02 Ventana Med Syst Inc IN-SITU-hybridisering med polytag-prober
AU2011220792A1 (en) 2010-02-26 2012-07-26 Ventana Medical Systems, Inc. Cytogenic analysis of metaphase chromosomes
EP2547732B1 (de) * 2010-03-15 2018-02-28 Purdue Research Foundation Farbstoffe mit strukturen höherer ordnung und verbesserten optischen merkmalen
JP5540867B2 (ja) * 2010-04-26 2014-07-02 コニカミノルタ株式会社 有機蛍光色素内包シリカナノ粒子、その製造方法、それを用いた生体物質標識剤
US20130261003A1 (en) 2010-08-06 2013-10-03 Ariosa Diagnostics, In. Ligation-based detection of genetic variants
US20120034603A1 (en) 2010-08-06 2012-02-09 Tandem Diagnostics, Inc. Ligation-based detection of genetic variants
DE102010042634A1 (de) 2010-10-19 2012-04-19 Atto-Tec Gmbh Neue Amin-substituierte tricyclische Fluoreszenzfarbstoffe
WO2012058633A1 (en) 2010-10-29 2012-05-03 Latham Gary J mPCR METHODS FOR ANALYZING REPEAT SEQUENCES
US10131947B2 (en) 2011-01-25 2018-11-20 Ariosa Diagnostics, Inc. Noninvasive detection of fetal aneuploidy in egg donor pregnancies
US20120190020A1 (en) 2011-01-25 2012-07-26 Aria Diagnostics, Inc. Detection of genetic abnormalities
WO2012103235A1 (en) 2011-01-25 2012-08-02 Ko Minoru S H Zscan4 as a marker for pancreatic stem cells and progenitor cells and use thereof
WO2012118745A1 (en) 2011-02-28 2012-09-07 Arnold Oliphant Assay systems for detection of aneuploidy and sex determination
CN103534359B (zh) 2011-03-14 2016-07-06 文塔纳医疗系统公司 分析染色体易位的方法及其系统
AU2012251027B2 (en) 2011-05-04 2015-03-26 Htg Molecular Diagnostics, Inc. Quantitative nuclease protection Assay (qNPA) and sequencing (qNPS) improvements
EP2707509A4 (de) 2011-05-12 2014-11-26 Netbio Inc Verfahren und zusammensetzungen zur schnellen multiplex-amplifikation von str-loci
WO2012159025A2 (en) 2011-05-18 2012-11-22 Life Technologies Corporation Chromosome conformation analysis
CA3113672A1 (en) 2011-07-01 2013-01-10 Htg Molecular Diagnostics, Inc. Methods of detecting gene fusions
JP5826071B2 (ja) * 2011-08-30 2015-12-02 富士フイルム株式会社 キサンテン誘導体の多量体構造を有する新規化合物、着色組成物、インクジェット記録用インク、インクジェット記録方法、カラーフィルター、及びカラートナー
AU2012309824A1 (en) 2011-09-12 2013-04-18 Abbvie Biotherapeutics Inc. Artificial NK cells and uses thereof
US9644241B2 (en) 2011-09-13 2017-05-09 Interpace Diagnostics, Llc Methods and compositions involving miR-135B for distinguishing pancreatic cancer from benign pancreatic disease
US9416153B2 (en) 2011-10-11 2016-08-16 Enzo Life Sciences, Inc. Fluorescent dyes
JP2014531908A (ja) 2011-10-14 2014-12-04 プレジデント アンド フェローズ オブ ハーバード カレッジ 構造アッセンブリによる配列決定
WO2013057586A1 (en) 2011-10-19 2013-04-25 Oslo Universitetssykehus Hf Compositions and methods for producing soluble t - cell receptors
WO2013108126A2 (en) 2012-01-16 2013-07-25 University Of Oslo Methyltransferases and uses thereof
CN102618086B (zh) * 2012-03-07 2013-12-11 东华大学 一种一步法制备梯形宽波段吸收聚炔方酸菁染料的方法
CN102634225B (zh) * 2012-03-24 2013-11-06 大连理工大学 5(6)取代的罗丹明异构体的拆分合成方法
WO2013167387A1 (en) 2012-05-10 2013-11-14 Ventana Medical Systems, Inc. Uniquely specific probes for pten, pik3ca, met, top2a, and mdm2
EP2852687A4 (de) 2012-05-21 2016-10-05 Scripps Research Inst Verfahren zur probenvorbereitung
WO2013184754A2 (en) 2012-06-05 2013-12-12 President And Fellows Of Harvard College Spatial sequencing of nucleic acids using dna origami probes
WO2014009535A2 (en) 2012-07-12 2014-01-16 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for predicting the survival time and treatment responsiveness of a patient suffering from a solid cancer with a signature of at least 7 genes
HUE036166T2 (hu) 2012-07-20 2018-06-28 Harvard College Sejtalapú minõségellenõrzõ bioassay-k gyógyhatású élelmiszerekhez és gyógyszertermékekhez
WO2014048942A1 (en) 2012-09-25 2014-04-03 Ventana Medical Systems, Inc. Probes for pten, pik3ca, met, and top2a, and method for using the probes
US9476089B2 (en) 2012-10-18 2016-10-25 President And Fellows Of Harvard College Methods of making oligonucleotide probes
US20160008783A1 (en) * 2013-02-15 2016-01-14 Empire Technology Development Llc Photocatalytic degradation of sugar
US9540685B2 (en) 2013-03-15 2017-01-10 President And Fellows Of Harvard College Methods of identifying homologous genes using FISH
WO2015036405A1 (en) 2013-09-10 2015-03-19 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for diagnosing and treating basal cell carcinoma
US20160265036A1 (en) 2013-11-05 2016-09-15 Htg Molecular Diagnostics, Inc. Methods for detecting nucleic acids
CA2935789A1 (en) 2014-01-05 2015-07-09 Biomirna Holdings Ltd. Lung cancer determinations using mirna
WO2015120382A1 (en) 2014-02-07 2015-08-13 The Johns Hopkins University Predicting response to epigenetic drug therapy
EP3110966A1 (de) 2014-02-24 2017-01-04 Ventana Medical Systems, Inc. Automatisierter rna-nachweis mit markierten 2'-o-methyl-rns-oligonukleotidsonden und signalverstärkungssystemen
EP3140277A1 (de) * 2014-05-07 2017-03-15 Danmarks Tekniske Universitet Verfahren zur herstellung von zwischenprodukten für carboxy-fluoreszeine sowie neuartiges carboxy-fluoreszein
AU2015305570C1 (en) 2014-08-19 2020-07-23 President And Fellows Of Harvard College RNA-guided systems for probing and mapping of nucleic acids
JP6940404B2 (ja) 2014-08-19 2021-09-29 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 核酸検出のための方法および組成物
WO2016040524A1 (en) 2014-09-09 2016-03-17 Igenomx International Genomics Corporation Methods and compositions for rapid nucleic acid library preparation
EP3009147A1 (de) 2014-10-16 2016-04-20 INSERM (Institut National de la Santé et de la Recherche Médicale) Verfahren zur Behandlung von resistenten Glioblastomen
KR102417849B1 (ko) 2014-11-21 2022-07-07 나노스트링 테크놀로지스, 인크. 무효소 및 무증폭 시퀀싱
WO2016094330A2 (en) 2014-12-08 2016-06-16 20/20 Genesystems, Inc Methods and machine learning systems for predicting the liklihood or risk of having cancer
JP2018502567A (ja) 2015-01-12 2018-02-01 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル 膵臓癌の診断方法
US9957393B2 (en) 2015-03-30 2018-05-01 Enzo Biochem, Inc. Monoazo dyes with cyclic amine as fluorescence quenchers
EP3292214A1 (de) 2015-05-04 2018-03-14 Academisch Medisch Centrum Verfahren zur quantifizierung von mirnas mittels normalisierung
AU2016297631B2 (en) 2015-07-23 2022-08-04 Asuragen, Inc. Methods, compositions, kits, and uses for analysis of nucleic acids comprising repeating A/T-rich segments
WO2017029391A1 (en) 2015-08-20 2017-02-23 INSERM (Institut National de la Santé et de la Recherche Médicale) New method for treating cancer
WO2017052679A1 (en) 2015-09-21 2017-03-30 The United States Of America, As Represented By The Secretary, Departmnet Of Health & Human Service Monoclonal antibodies specific for heartland virus and methods of their use
WO2017055326A1 (en) 2015-09-29 2017-04-06 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for quantifying the population of myeloid dendritic cells in a tissue sample
WO2017055319A1 (en) 2015-09-29 2017-04-06 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for quantifying the population of b cells in a tissue sample
WO2017055325A1 (en) 2015-09-29 2017-04-06 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for quantifying the population of nk cells in a tissue sample
WO2017055320A1 (en) 2015-09-29 2017-04-06 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for quantifying the population of cytotoxic lymphocytes in a tissue sample
WO2017055321A1 (en) 2015-09-29 2017-04-06 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for quantifying the population of fibroblasts in a tissue sample
WO2017055324A1 (en) 2015-09-29 2017-04-06 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for quantifying the population of cells of monocytic origin in a tissue sample
WO2017055327A1 (en) 2015-09-29 2017-04-06 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for quantifying the population of endothelial cells in a tissue sample
WO2017055322A1 (en) 2015-09-29 2017-04-06 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for quantifying the population of neutrophils in a tissue sample
WO2017060397A1 (en) 2015-10-09 2017-04-13 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for predicting the survival time of subjects suffering from melanoma metastases
WO2017067944A1 (en) 2015-10-19 2017-04-27 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for predicting the survival time of subjects suffering from triple negative breast cancer
EP3371594A1 (de) 2015-11-06 2018-09-12 Ventana Medical Systems, Inc. Repräsentative diagnose
EP3374518B1 (de) 2015-11-10 2019-11-06 INSERM (Institut National de la Santé et de la Recherche Médicale) Verfahren zur vorhersage der überlebenszeit von patienten mit dekompensierter alkoholzirrhose
US10760135B2 (en) 2016-01-13 2020-09-01 Inserm (Institut National De La Sante Et De La Recherche Medicale) Methods for predicting pancreatic cancer treatment response
WO2017182834A1 (en) 2016-04-19 2017-10-26 INSERM (Institut National de la Santé et de la Recherche Médicale) New method for treating resistant glioblastoma
EP3458601B1 (de) 2016-05-16 2023-07-05 Nanostring Technologies, Inc. Verfahren zur erkennung von zielnukleinsäuren in einer probe
WO2017200790A1 (en) 2016-05-20 2017-11-23 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Real-time reverse transcriptase-polymerase chain reaction assay with modified probe for the diagnosis of rabies viruses and other lyssaviruses
WO2017202962A1 (en) 2016-05-24 2017-11-30 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment of non small cell lung cancer (nsclc) that coexists with chronic obstructive pulmonary disease (copd)
EP3468590A1 (de) 2016-06-13 2019-04-17 The United States of America, as represented by the Secretary, Department of Health and Human Services Nukleinsäuren zur codierung von zika-virus-ähnlichen partikeln und deren verwendung in zika-virus-impfstoffen und diagnostischen tests
JP2019520071A (ja) 2016-06-14 2019-07-18 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル 急性重症大腸炎の処置応答を予測するための方法
CN116840465A (zh) * 2016-06-28 2023-10-03 文塔纳医疗系统公司 用多染料醌甲基化物和酪酰胺缀合物的显色ihc和ish染色的新颜色
WO2018011107A1 (en) 2016-07-11 2018-01-18 INSERM (Institut National de la Santé et de la Recherche Médicale) Use of er-alpha 46 in methods and kits for assessing the status of breast cancer
WO2018011166A2 (en) 2016-07-12 2018-01-18 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for quantifying the population of myeloid dendritic cells in a tissue sample
WO2018045162A1 (en) 2016-09-01 2018-03-08 Biogen Ma Inc. Biomarkers predictive of primary progressive multiple sclerosis and uses thereof
WO2018046736A1 (en) 2016-09-12 2018-03-15 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for predicting the survival time of patients suffering from cancer
WO2018046738A1 (en) 2016-09-12 2018-03-15 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for predicting the survival time of patients suffering from cancer
WO2018054960A1 (en) 2016-09-21 2018-03-29 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for predicting and treating resistance to chemotherapy in npm-alk(+) alcl
US20200016177A1 (en) 2016-09-22 2020-01-16 Inserm (Institut National De La Sante Et De La Recherche Medicale) Methods and pharmaceutical compositions for reprograming immune environment in a subject in need thereof
CN110234600B (zh) 2016-10-21 2023-03-21 美国政府(由卫生和人类服务部的部长所代表) 分子纳米标签
AU2017361521B2 (en) 2016-11-21 2020-08-27 Bruker Spatial Biology, Inc. Chemical compositions and methods of using same
WO2018122245A1 (en) 2016-12-28 2018-07-05 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods of predicting the survival time of patients suffering from cms3 colorectal cancer
WO2018122249A1 (en) 2016-12-28 2018-07-05 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for predicting the survival time of patients suffering from a microsatellite stable colorectal cancer
WO2018146239A1 (en) 2017-02-10 2018-08-16 INSERM (Institut National de la Santé et de la Recherche Médicale) Biomarker for outcome in aml patients
WO2018162404A1 (en) 2017-03-06 2018-09-13 INSERM (Institut National de la Santé et de la Recherche Médicale) Biomarker for outcome in aml patients
WO2018172540A1 (en) 2017-03-24 2018-09-27 INSERM (Institut National de la Santé et de la Recherche Médicale) Method to predict the progression of alzheimer's disease
EP3601613B1 (de) 2017-03-29 2021-12-01 INSERM (Institut National de la Santé et de la Recherche Médicale) Verfahren zur beurteilung eines schwangerschaftsergebnisses
WO2018189215A1 (en) 2017-04-12 2018-10-18 INSERM (Institut National de la Santé et de la Recherche Médicale) Method for predicting the survival time of a patient suffering from hepatocellular carcinoma
CN110914448A (zh) 2017-06-02 2020-03-24 昂飞股份有限公司 使用差异性标记的等位基因特异性探针分析混合样品的基于阵列的方法
WO2018223053A1 (en) 2017-06-02 2018-12-06 Affymetrix, Inc. Array-based methods for analysing mixed samples using differently labelled allele-specific probes
WO2019038219A1 (en) 2017-08-21 2019-02-28 INSERM (Institut National de la Santé et de la Recherche Médicale) NEW PROGNOSTIC METHOD OF PANCREATIC CANCER
WO2019043138A1 (en) 2017-09-01 2019-03-07 INSERM (Institut National de la Santé et de la Recherche Médicale) METHOD FOR PREDICTING OUTCOME OF CANCER
US11579147B2 (en) 2017-09-25 2023-02-14 INSERM (Institut National de la Santé et de la Recherche Médicale) Use of VNN1 as a biomarker and a therapeutic target in sarcomas
US11639930B2 (en) 2017-11-02 2023-05-02 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Enhanced chemiluminescent enzyme-linked immunosorbent assay for detection of antibodies against Babesia microti
EP3710820A1 (de) 2017-11-13 2020-09-23 F. Hoffmann-La Roche AG Vorrichtungen zur probenanalyse mittels epitachophorese
WO2019104070A1 (en) 2017-11-21 2019-05-31 Nanostring Technologies, Inc. O-nitrobenzyl photocleavable bifunctional linker
WO2019133727A1 (en) 2017-12-29 2019-07-04 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Universal influenza virus probe set for enrichment of any influenza virus nucleic acid
WO2019207030A1 (en) 2018-04-26 2019-10-31 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for predicting a response with an immune checkpoint inhibitor in a patient suffering from a lung cancer
AU2019271028A1 (en) 2018-05-14 2020-12-03 Bruker Spatial Biology, Inc. Chemical compositions and methods of using same
WO2019229489A1 (en) 2018-05-31 2019-12-05 INSERM (Institut National de la Santé et de la Recherche Médicale) Use of mir-146a-5p and mir-186 as biomarkers of osteoarthritis
WO2020030954A1 (en) 2018-08-09 2020-02-13 Integrative Medicine Clinic, Sia Theranostics-like protein sanps conjugated to integrin and pmsa targeting peptides and therapy of prostate cancer
US10513610B1 (en) * 2018-08-20 2019-12-24 Laiqiang Ying Sulfonated 4,7-dichlororhodamine dyes and their application
WO2020089428A1 (en) 2018-11-02 2020-05-07 INSERM (Institut National de la Santé et de la Recherche Médicale) New prognostic method of pancreatic cancer
WO2020089432A1 (en) 2018-11-02 2020-05-07 INSERM (Institut National de la Santé et de la Recherche Médicale) New prognostic method of pancreatic cancer
WO2020132607A1 (en) 2018-12-20 2020-06-25 Life Technologies Corporation Asymmetric rhodamine dye and use thereof in biological assays
MX2021007494A (es) 2018-12-20 2021-10-13 Life Technologies Corp Colorante de rodamina modificado y uso del mismo en ensayos biológicos.
EP4059569A1 (de) 2019-01-03 2022-09-21 Institut National De La Sante Et De La Recherche Medicale (Inserm) Verfahren und pharmazeutische zusammensetzungen zur verbesserung der cd8+-t-zellabhängigen immunantworten bei personen mit krebs
WO2020148349A1 (en) 2019-01-16 2020-07-23 INSERM (Institut National de la Santé et de la Recherche Médicale) Variants of erythroferrone and their use
EP3918096A1 (de) 2019-01-31 2021-12-08 The United States of America, as represented by the Secretary, Department of Health and Human Services Verfahren und zusammensetzungen zur detektion von transfusionsübertragenen pathogenen
US20220098674A1 (en) 2019-02-13 2022-03-31 Inserm (Institut National De La Santé Et Dr La Recherch Médicale) Methods and compositions for selecting a cancer treatment in a subject suffering from cancer
WO2020182932A1 (en) 2019-03-13 2020-09-17 INSERM (Institut National de la Santé et de la Recherche Médicale) New gene signatures for predicting survival time in patients suffering from renal cell carcinoma
WO2020193740A1 (en) 2019-03-28 2020-10-01 INSERM (Institut National de la Santé et de la Recherche Médicale) New strategy for treating pancreatic cancer
US20220177978A1 (en) 2019-04-02 2022-06-09 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods of predicting and preventing cancer in patients having premalignant lesions
EP3719144A1 (de) 2019-04-05 2020-10-07 Fundación para la Investigación Biomédica del Hospital Universitario de la Paz (FIBHULP) Mir-151a-3p als universelle endogene steuerung zur exosomenladungsnormalisierung
JP7518853B2 (ja) 2019-04-15 2024-07-18 インサーム（インスティテュ ナシオナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシェ メディカル） 細胞集団のエネルギー代謝をプロファイリングする方法
US20220211741A1 (en) 2019-04-18 2022-07-07 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for the treatment and prognosis of cancer
US20220290237A1 (en) 2019-04-24 2022-09-15 INSERM (Institut National de la Santé et de la Recherche Médicale) Method for predicting the response of antipsychotic drugs
WO2020229437A1 (en) 2019-05-14 2020-11-19 F. Hoffmann-La Roche Ag Devices and methods for sample analysis
WO2020229521A1 (en) 2019-05-14 2020-11-19 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for inhibiting or reducing bacterial biofilms on a surface
WO2021001539A1 (en) 2019-07-04 2021-01-07 INSERM (Institut National de la Santé et de la Recherche Médicale) New strategy to detect and treat eosinophilic fasciitis
WO2021004379A1 (zh) * 2019-07-05 2021-01-14 南京金斯瑞生物科技有限公司 一种荧光标记核酸及其合成方法
WO2021013592A1 (en) 2019-07-19 2021-01-28 Fundación Para La Investigación Biomédica Del Hospital Universitario La Paz (Fibhulp) Method for determining the response to treatment of a patient affected by non-small cell lung carcinoma (nsclc)
EP4025712A1 (de) 2019-09-05 2022-07-13 Institut National de la Santé et de la Recherche Médicale (INSERM) Verfahren zur behandlung und prognose akuter myeloischer leukämie
WO2021063968A1 (en) 2019-09-30 2021-04-08 INSERM (Institut National de la Santé et de la Recherche Médicale) Method and composition for diagnosing chronic obstructive pulmonary disease
CA3157889A1 (en) 2019-10-17 2021-04-22 Inserm (Institut National De La Sante Et De La Recherche Medicale) Methods for diagnosing nasal intestinal type adenocarcinomas
IL292313A (en) 2019-10-18 2022-06-01 Univ Leland Stanford Junior Whole tissue sequencing on a clinical and industrial scale
WO2021170777A1 (en) 2020-02-28 2021-09-02 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for diagnosing, prognosing and managing treatment of breast cancer
WO2021178893A2 (en) 2020-03-06 2021-09-10 Singular Genomics Systems, Inc. Linked paired strand sequencing
WO2021186014A1 (en) 2020-03-20 2021-09-23 INSERM (Institut National de la Santé et de la Recherche Médicale) Method for predicting the survival time of a patient suffering from a cancer
EP4165214A1 (de) 2020-06-10 2023-04-19 Institut National de la Santé et de la Recherche Médicale (INSERM) Verfahren zur behandlung und prognose von krebs wie glioblastom
US20230218608A1 (en) 2020-06-18 2023-07-13 INSERM (Institut National de la Santé et de la Recherche Médicale) New strategy for treating pancreatic cancer
WO2022015600A2 (en) 2020-07-13 2022-01-20 Singular Genomics Systems, Inc. Methods of sequencing complementary polynucleotides
WO2022018163A1 (en) 2020-07-22 2022-01-27 INSERM (Institut National de la Santé et de la Recherche Médicale) Method for predicting survival time in patients suffering from cancer
CN116323965A (zh) 2020-07-23 2023-06-23 生命技术公司 使用染料的用于生物分析的组合物、系统和方法
EP4185857A2 (de) 2020-07-23 2023-05-31 Life Technologies Corporation Systeme und verfahren zur biologischen analyse
WO2022056078A1 (en) 2020-09-11 2022-03-17 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Rnase h-assisted detection assay for rna (radar)
KR20230096993A (ko) 2020-09-16 2023-06-30 나노스트링 테크놀로지스, 인크. 화학적 조성물 및 이의 사용 방법
WO2022064049A1 (en) 2020-09-28 2022-03-31 INSERM (Institut National de la Santé et de la Recherche Médicale) Method for diagnosing brucella infection
EP4232603A1 (de) 2020-10-20 2023-08-30 Institut National de la Santé et de la Recherche Médicale (INSERM) Verfahren zur vorhersage der reaktion auf tnf-inhibitoren
WO2022087485A1 (en) 2020-10-22 2022-04-28 Singular Genomics Systems, Inc. Nucleic acid circularization and amplification on a surface
US12071667B2 (en) 2020-11-04 2024-08-27 10X Genomics, Inc. Sequence analysis using meta-stable nucleic acid molecules
WO2022096633A1 (en) 2020-11-06 2022-05-12 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for diagnosis and treating polycystic ovary syndrome (pcos)
WO2022135753A1 (en) 2020-12-21 2022-06-30 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for prognosis the humoral response of a subject prior to vaccination
WO2022136252A1 (en) 2020-12-21 2022-06-30 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for prognosis the humoral response of a subject prior to vaccination
WO2022152698A1 (en) 2021-01-12 2022-07-21 INSERM (Institut National de la Santé et de la Recherche Médicale) Use of npdk-d to evaluate cancer prognosis
US12060603B2 (en) 2021-01-19 2024-08-13 10X Genomics, Inc. Methods for internally controlled in situ assays using padlock probes
EP4251770A4 (de) 2021-02-08 2024-05-29 Singular Genomics Systems, Inc. Verfahren und zusammensetzungen zur sequenzierung komplementärer polynukleotide
WO2022171611A1 (en) 2021-02-09 2022-08-18 INSERM (Institut National de la Santé et de la Recherche Médicale) New method to pronostic lung cancer
US11884977B2 (en) 2021-03-12 2024-01-30 Singular Genomics Systems, Inc. Nanoarrays and methods of use thereof
WO2022192671A1 (en) 2021-03-12 2022-09-15 Singular Genomics Systems, Inc. Nanoarrays and methods of use thereof
WO2022194949A1 (en) 2021-03-17 2022-09-22 INSERM (Institut National de la Santé et de la Recherche Médicale) Method for diagnosing pancreatic cancer
WO2022207566A1 (en) 2021-03-29 2022-10-06 INSERM (Institut National de la Santé et de la Recherche Médicale) New method to evaluate pancreatic cancer prognosis
EP4326903A1 (de) 2021-04-23 2024-02-28 Inserm (Institut National De La Sante Et De La Recherche Medicale) Verfahren und zusammensetzungen zur behandlung von krankheiten im zusammenhang mit zellalterungsansammlung
US11578320B2 (en) 2021-04-27 2023-02-14 Singular Genomics Systems, Inc. High density sequencing and multiplexed priming
EP4347877A1 (de) 2021-06-01 2024-04-10 10X Genomics, Inc. Verfahren und zusammensetzungen zum nachweis von analyten und zur sondenauflösung
CN117751197A (zh) 2021-06-02 2024-03-22 10X基因组学有限公司 使用不对称可环化探针的样品分析
EP4367269A1 (de) 2021-07-05 2024-05-15 Inserm (Institut National De La Sante Et De La Recherche Medicale) Gensignaturen zur vorhersage der überlebenszeit bei patienten mit nierenzellkarzinom
US20230026886A1 (en) 2021-07-13 2023-01-26 10X Genomics, Inc. Methods for preparing polymerized matrix with controllable thickness
CA3224093A1 (en) 2021-07-30 2023-02-02 Jorge Ivan Hernandez Neuta Methods and compositions for synchronizing reactions in situ
US20230057571A1 (en) 2021-08-03 2023-02-23 10X Genomics, Inc. Nucleic acid concatemers and methods for stabilizing and/or compacting the same
EP4446426A3 (de) 2021-08-16 2024-11-13 10x Genomics, Inc. Sonden mit einem geteilten strichcodebereich und verfahren zur verwendung
WO2023089159A1 (en) 2021-11-22 2023-05-25 INSERM (Institut National de la Santé et de la Recherche Médicale) New strategy targeting stroma/tumor cell crosstalk to treat a cancer
US20230242974A1 (en) 2021-12-27 2023-08-03 10X Genomics, Inc. Methods and compositions for rolling circle amplification
US20230279475A1 (en) 2022-01-21 2023-09-07 10X Genomics, Inc. Multiple readout signals for analyzing a sample
WO2023144303A1 (en) 2022-01-31 2023-08-03 INSERM (Institut National de la Santé et de la Recherche Médicale) Cd38 as a biomarker and biotarget in t-cell lymphomas
WO2023152133A1 (en) 2022-02-08 2023-08-17 INSERM (Institut National de la Santé et de la Recherche Médicale) Method for diagnosing colorectal cancer
IL315106A (en) 2022-02-23 2024-10-01 Insitro Inc Superimposed optical scanning and transcriptional measurements of cells containing barcoded genetic disorders
WO2023172665A2 (en) 2022-03-10 2023-09-14 Singular Genomics Systems, Inc. Nucleic acid delivery scaffolds
WO2023192616A1 (en) 2022-04-01 2023-10-05 10X Genomics, Inc. Compositions and methods for targeted masking of autofluorescence
WO2023215612A1 (en) 2022-05-06 2023-11-09 10X Genomics, Inc. Analysis of antigen and antigen receptor interactions
US20240026427A1 (en) 2022-05-06 2024-01-25 10X Genomics, Inc. Methods and compositions for in situ analysis of v(d)j sequences
WO2023220300A1 (en) 2022-05-11 2023-11-16 10X Genomics, Inc. Compositions and methods for in situ sequencing
US20240035071A1 (en) 2022-06-17 2024-02-01 10X Genomics, Inc. Catalytic de-crosslinking of samples for in situ analysis
US20240101978A1 (en) 2022-08-12 2024-03-28 10X Genomics, Inc. Puma1 polymerases and uses thereof
WO2024040060A1 (en) 2022-08-16 2024-02-22 10X Genomics, Inc. Ap50 polymerases and uses thereof
WO2024061930A1 (en) 2022-09-22 2024-03-28 Institut National de la Santé et de la Recherche Médicale New method to treat and diagnose peripheral t-cell lymphoma (ptcl)
US20240191297A1 (en) 2022-10-14 2024-06-13 10X Genomics, Inc. Methods, compositions, and systems for assessing biological sample quality
WO2024102736A1 (en) 2022-11-08 2024-05-16 10X Genomics, Inc. Immobilization methods and compositions for in situ detection
WO2024107887A1 (en) 2022-11-16 2024-05-23 10X Genomics, Inc. Methods and compositions for assessing performance of in situ assays
WO2024115935A1 (en) 2022-11-29 2024-06-06 Inserm Methods for the treatment of b-cell lymphoma using cd39 inhibitors
WO2024130203A1 (en) 2022-12-16 2024-06-20 10X Genomics, Inc. Methods and compositions for assessing performance
US20240263219A1 (en) 2023-01-06 2024-08-08 10X Genomics, Inc. Methods and compositions for in situ analysis of variant sequences
WO2024163948A2 (en) 2023-02-03 2024-08-08 10X Genomics, Inc. In situ analysis of variant sequences in biological samples
WO2024191684A1 (en) 2023-03-10 2024-09-19 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Detection of hepatitis c virus ribonucleic acid from whole blood using reverse transcription loop-mediated isothermal amplification
WO2024196764A2 (en) 2023-03-17 2024-09-26 Nanostring Technologies, Inc. Assay for recombinase accessible chromatin and related compositions and methods

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0148356B1 (de) * 1982-09-30 1990-12-05 Aktiebolaget Iro Garnspeicher- und Zuführvorrichtung
US4490543A (en) * 1982-11-12 1984-12-25 University Of Northern Iowa Foundation Low toxicity radiation sensitizer
EP0201751A2 (de) * 1985-05-08 1986-11-20 Abbott Laboratories 4-Aminomethylfluoreszeinderivate zur Verwendung in Fluoreszenz-Polarisationsimmunotesten
US4996143A (en) * 1985-12-23 1991-02-26 Syngene, Inc. Fluorescent stokes shift probes for polynucleotide hybridization
CA1273552A (en) * 1985-12-23 1990-09-04 Michael J. Heller Fluorescent stokes shift probes for polynucleotide hybridization assays
US4780421A (en) * 1986-04-03 1988-10-25 Sclavo Inc. Cleavable labels for use in binding assays
US5188934A (en) * 1989-11-14 1993-02-23 Applied Biosystems, Inc. 4,7-dichlorofluorescein dyes as molecular probes
US5401847A (en) * 1990-03-14 1995-03-28 Regents Of The University Of California DNA complexes with dyes designed for energy transfer as fluorescent markers
US5405975A (en) * 1993-03-29 1995-04-11 Molecular Probes, Inc. Fluorescent ion-selective diaryldiaza crown ether conjugates
US5453517A (en) * 1992-02-25 1995-09-26 Molecular Probes, Inc. Reactive derivatives of bapta used to make ion-selective chelators
JPH04107559A (ja) * 1990-08-29 1992-04-09 Kao Corp 感光性組成物及びそれを用いた硬化像の形成方法
US5187085A (en) * 1990-09-28 1993-02-16 Applied Biosystems, Inc. Nucleic acid sequence analysis with nucleoside-5'-o-(1-thiotriphosphates)
ATE152831T1 (de) * 1991-09-16 1997-05-15 Molecular Probes Inc Dimere unsymmetrische cyaninfarbstoffe
US5747244A (en) * 1991-12-23 1998-05-05 Chiron Corporation Nucleic acid probes immobilized on polystyrene surfaces
CA2087413A1 (en) * 1992-01-17 1993-07-18 Joseph R. Lakowicz Fluorescent energy transfer immunoassay
EP0658167B1 (de) * 1992-09-03 1999-04-14 The Perkin-Elmer Corporation 4,7-dichlorofluoroszein-farbestoffe als molekulare sonden
EP0601889A2 (de) * 1992-12-10 1994-06-15 Maine Medical Center Research Institute Nukleinsäure-Sonden
JP3368011B2 (ja) * 1993-10-04 2003-01-20 キヤノン株式会社 核酸検出法
US5654419A (en) * 1994-02-01 1997-08-05 The Regents Of The University Of California Fluorescent labels and their use in separations
US5565554A (en) * 1994-07-29 1996-10-15 The Regents Of The University Of California Dimeric fluorescent energy transfer dyes comprising asymmetric cyanine azole-indolenine chromophores
WO1996004059A1 (en) * 1994-08-03 1996-02-15 Langley James S Steam enhancer
US5741657A (en) * 1995-03-20 1998-04-21 The Regents Of The University Of California Fluorogenic substrates for β-lactamase and methods of use
US6008373A (en) * 1995-06-07 1999-12-28 Carnegie Mellon University Fluorescent labeling complexes with large stokes shift formed by coupling together cyanine and other fluorochromes capable of resonance energy transfer
US5728528A (en) * 1995-09-20 1998-03-17 The Regents Of The University Of California Universal spacer/energy transfer dyes
US5800996A (en) * 1996-05-03 1998-09-01 The Perkin Elmer Corporation Energy transfer dyes with enchanced fluorescence

Also Published As

Publication number Publication date
AU1999597A (en) 1997-11-20
JP2004068023A (ja) 2004-03-04
JP3090626B2 (ja) 2000-09-25
JP2004043819A (ja) 2004-02-12
JP3499238B2 (ja) 2004-02-23
JP2000154332A (ja) 2000-06-06
EP0805190A2 (de) 1997-11-05
US5800996A (en) 1998-09-01
EP0940450A1 (de) 1999-09-08
AU691143B2 (en) 1998-05-07
ATE187752T1 (de) 2000-01-15
DE69700935D1 (de) 2000-01-20
JP2000154381A (ja) 2000-06-06
JP2004250713A (ja) 2004-09-09
CA2203494C (en) 2000-12-26
EP0805190A3 (de) 1998-01-07
EP0940450B1 (de) 2006-08-02
DE69700935T2 (de) 2000-04-27
EP0805190B1 (de) 1999-12-15
JP2000187036A (ja) 2000-07-04
DE69736434D1 (de) 2006-09-14
JPH1088124A (ja) 1998-04-07
JP3592173B2 (ja) 2004-11-24
CA2203494A1 (en) 1997-11-03
JP2003274999A (ja) 2003-09-30
DE69736434T2 (de) 2007-03-01

Similar Documents

Publication Publication Date Title
DE69736434D1 (de) Energieübertragungsfarbstoffe mit verbesserter Fluoreszenz
ATE92501T1 (de) Monoklonale antikoerper gegen zyklosporine.
AU682290B2 (en) Nucleotides labelled with an infra-red dye and their use in nucleic acid detection
DE60042163D1 (de) Mit uv-licht anregbare fluoreszenzenergietransfer-farbstoffe
CA2182516A1 (en) Probes labelled with energy transfer coupled dyes
AR033472A1 (es) Concentrados de agentes anticongelantes que contienen el colorante c.i. reactive violet 5
ES2104881T3 (es) Procedimiento para teñir papel con colorantes diazoicos.
GB9812596D0 (en) Energy transfer assay method
ATE301122T1 (de) Kernerweiterte perylenbisimide und ihre verwendung als fluoreszenzfarbstoffe
ATE284407T1 (de) Pyrimidinderivate als markierte bindungspartner
ES8602891A1 (es) Procedimiento para la obtencion de colorantes de trifendio- xazin-vinilsulfona
ES2064438T3 (es) Materiales de transferencia termica de colorantes.
DE68912462D1 (de) Xanthenfarbstoffe.
ATE248207T1 (de) Farbstoffmischungen von wasserlöslichen faserreaktiven azofarbstoffen und ihre verwendung
ES2106799T3 (es) Mezcla de colorantes de dispersion.
ES2186008T3 (es) Colorantes de reticulocito excitables por helio-neon y derivables de halolepidinas.
ATE407142T1 (de) Chimäres gpf-aequorin als bioluminiszenter ca++ marker auf einzelzellniveau
ATE245135T1 (de) Neue hydrochinonderivativen als abfänger für oxidierten entwickler
ES2095900T3 (es) Mezcla de colorantes dispersantes y procedimiento de coloracion.
ATE221764T1 (de) Oxidationsfärbemittel
DE69809952D1 (de) Verbrückte monoazoverbindungen
WO2004029578A3 (en) Energy transfer dyes, terminators and use thereof
KR930011920A (ko) 모발의 염색방법 및 장치
ATE357484T1 (de) Anionische monoazofarbstoffe
FR2409285A1 (fr) Colorants anthraquinoniques

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties