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ATE235510T1 - Integrinbindendes peptid und dessen verwendung - Google Patents

Integrinbindendes peptid und dessen verwendung

Info

Publication number
ATE235510T1
ATE235510T1 AT98933671T AT98933671T ATE235510T1 AT E235510 T1 ATE235510 T1 AT E235510T1 AT 98933671 T AT98933671 T AT 98933671T AT 98933671 T AT98933671 T AT 98933671T AT E235510 T1 ATE235510 T1 AT E235510T1
Authority
AT
Austria
Prior art keywords
binding peptide
integrin binding
lysine
peptides
integrin
Prior art date
Application number
AT98933671T
Other languages
English (en)
Inventor
Jyrki Heino
Johanna Ivaska
Jarmo Kaepylae
Original Assignee
Biotie Therapies Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biotie Therapies Corp filed Critical Biotie Therapies Corp
Application granted granted Critical
Publication of ATE235510T1 publication Critical patent/ATE235510T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AT98933671T 1997-07-11 1998-07-09 Integrinbindendes peptid und dessen verwendung ATE235510T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/893,526 US6096707A (en) 1997-07-11 1997-07-11 Integrin binding peptide and use thereof
PCT/FI1998/000579 WO1999002551A1 (en) 1997-07-11 1998-07-09 Integrin binding peptide and use thereof

Publications (1)

Publication Number Publication Date
ATE235510T1 true ATE235510T1 (de) 2003-04-15

Family

ID=25401719

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98933671T ATE235510T1 (de) 1997-07-11 1998-07-09 Integrinbindendes peptid und dessen verwendung

Country Status (17)

Country Link
US (1) US6096707A (de)
EP (1) EP0994898B1 (de)
JP (1) JP2001509515A (de)
KR (1) KR100571046B1 (de)
CN (1) CN1262688A (de)
AT (1) ATE235510T1 (de)
AU (1) AU748134B2 (de)
BR (1) BR9810586A (de)
CA (1) CA2295219C (de)
DE (1) DE69812630T2 (de)
ES (1) ES2195361T3 (de)
HU (1) HU225326B1 (de)
NO (1) NO20000126L (de)
NZ (1) NZ501767A (de)
PL (1) PL338001A1 (de)
RU (1) RU2203902C2 (de)
WO (1) WO1999002551A1 (de)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7914814B2 (en) * 1997-09-17 2011-03-29 Strategic Science & Technologies, Llc Topical delivery of arginine of cause beneficial effects
US6962974B1 (en) 1998-06-17 2005-11-08 Beth Israel Deaconess Medical Center Anti-angiogenic proteins and fragments and methods of use thereof
US6759047B1 (en) 1998-06-17 2004-07-06 Beth Israel Deaconess Hospital Corp. Anti-angiogenic proteins and methods of use thereof
US7387779B2 (en) 1998-06-17 2008-06-17 Beth Israel Deaconess Medical Center Anti-angiogenic proteins and fragments and methods of use thereof
GB9817623D0 (en) * 1998-08-13 1998-10-07 Glaxo Group Ltd Pharmaceutical compounds
ES2280502T3 (es) * 2001-02-21 2007-09-16 EISAI R&D MANAGEMENT CO., LTD. Metodo para evaluar el efecto de un inhibidor de la angiogenesis a traves de la inhibicion de la expresion de integrinas.
EP1372720A4 (de) * 2001-03-02 2006-07-26 Medimmune Inc Verfahren zur prävention oder behandlung von entzündlichen erkrankungen oder autoimmunkrankheiten durch verabreichung von integrin-alphav-beta3-antagonisten
EP1487489A4 (de) * 2002-03-04 2008-10-01 Medimmune Inc VERFAHREN ZUR PRÄVENTION ODER BEHANDLUNG VON ERKRANKUNGEN DURCH VERABREICHUNG EINES INTEGRIN avb3 ANTAGONISTEN IN KOMBINATION MIT EINEM HMG-CoA REDUKTASE-HEMMER ODER EINEM BISPHOSPHONAT
EP1487492A4 (de) * 2002-03-04 2008-10-01 Medimmune Inc Prävention oder behandlung von krebs mit integrin alphavbeta3 antagonisten in kombination mit anderen mitteln
CA2481747A1 (en) 2002-04-12 2003-10-23 Medimmune, Inc. Recombinant anti-interleukin-9 antibodies
WO2003092632A2 (en) * 2002-05-06 2003-11-13 The Scripps Research Institute Cyclic peptide anti-cancer agents and methods
EP1596884A2 (de) * 2003-01-30 2005-11-23 Medimmune, Inc. Verwendung von integrin alphabeta3 antagonisten
KR101224235B1 (ko) * 2003-04-11 2013-01-25 메디뮨 엘엘씨 재조합 ｉｌ­９ 항체 및 그의 용도
US7196061B2 (en) * 2003-09-10 2007-03-27 Wyeth Compounds that modulate neuronal growth and their uses
US7351739B2 (en) * 2004-04-30 2008-04-01 Wellgen, Inc. Bioactive compounds and methods of uses thereof
EP2422811A2 (de) 2004-10-27 2012-02-29 MedImmune, LLC Modulation von Antikörperspezifität mittels Anpassung der Affinität zu verwandten Antigenen
JP2008542445A (ja) * 2005-06-07 2008-11-27 ザ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・ペンシルバニア α２β１／ＧＰＩａ−ＩＩａインテグリン阻害剤
US8987306B2 (en) * 2005-06-07 2015-03-24 The Trustees Of The University Of Pennsylvania Inhibitors of integrin alpha2beta1 based on prolyl diaminopropionic acid scaffold
WO2007020405A2 (en) * 2005-08-12 2007-02-22 Cartela R & D Ab Integrin i-domain binding peptides
JP4826721B2 (ja) * 2005-08-18 2011-11-30 三菱電機株式会社 マンコンベアの制御装置
WO2007027742A2 (en) * 2005-08-31 2007-03-08 The Trustees Of The University Of Pennsylvania SMALL MOLECULE INTEGRIN α2βl/GPIa-IIa ANTAGONISTS
JP2009510105A (ja) 2005-09-28 2009-03-12 バイオバスキュラー インコーポレーティッド 血小板および細胞の接着、細胞移動、および炎症を阻止するための方法および組成物
CA2655448C (en) * 2005-12-22 2016-09-06 Novabiotics Limited Cyclic antimicrobial peptides
EP2851064A3 (de) 2006-07-11 2015-08-05 Roy C. Levitt Prävention und Therapie von Rhinosinusitis mit proinflammatorischen Zytokinhemmern
DK2068889T3 (da) 2006-08-10 2020-02-03 Roy C Levitt Anakinra til anvendelse i behandling af bronchiolitis obliterans syndrom
GB0618512D0 (en) * 2006-09-20 2006-11-01 Lexcicon Ltd Peptides
FI20075258A0 (fi) * 2007-04-17 2007-04-17 Biotie Therapies Corp Menetelmä integriiniinhibiittorirespondereiden seulomiseksi
WO2009052449A1 (en) * 2007-10-17 2009-04-23 University Of Southern California Novel peptides and uses thereof
US8563690B2 (en) * 2008-11-03 2013-10-22 The Board Of Trustees Of The University Of Illinois Modulation of platelet aggregation
US8853149B2 (en) 2010-03-19 2014-10-07 H. Lee Moffitt Cancer Center And Research Institute, Inc. Integrin interaction inhibitors for the treatment of cancer
US9238056B2 (en) * 2011-02-22 2016-01-19 Leo Pharma A/S Cyclic peptide and conjugate thereof for binding to keratinocytes
US10011635B2 (en) 2013-09-27 2018-07-03 H. Lee Moffitt Cancer Center And Research Institute, Inc. Cyclic peptide conjugates and methods of use
EP4056194A1 (de) * 2015-02-27 2022-09-14 Board of Regents, The University of Texas System Polypeptidtherapeutika und verwendungen davon
WO2020055812A1 (en) 2018-09-10 2020-03-19 Lung Therapeutics, Inc. Modified peptide fragments of cav-1 protein and the use thereof in the treatment of fibrosis

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5179007A (en) * 1989-07-07 1993-01-12 The Texas A & M University System Method and vector for the purification of foreign proteins
WO1994014836A1 (en) * 1992-12-18 1994-07-07 Centocor, Inc. Peptide inhibitors of selectin binding
US5627263A (en) * 1993-11-24 1997-05-06 La Jolla Cancer Research Foundation Integrin-binding peptides
JPH10502349A (ja) * 1994-06-29 1998-03-03 テキサス・バイオテクノロジー・コーポレイシヨン インテグリンα▲下４▼β▲下１▼のＶＣＡＭ−１またはフィブロネクチンへの結合を阻害する方法
WO1996040781A1 (en) * 1995-06-07 1996-12-19 Tanabe Seiyaku Co., Ltd. CYCLIC PEPTIDE INHIBITORS OF β1 AND β2 INTEGRIN-MEDIATED ADHESION

Also Published As

Publication number Publication date
KR100571046B1 (ko) 2006-04-13
BR9810586A (pt) 2000-09-05
ES2195361T3 (es) 2003-12-01
EP0994898B1 (de) 2003-03-26
DE69812630T2 (de) 2004-02-05
CA2295219A1 (en) 1999-01-21
PL338001A1 (en) 2000-09-25
KR20010015547A (ko) 2001-02-26
HUP0002789A3 (en) 2003-08-28
WO1999002551A1 (en) 1999-01-21
NZ501767A (en) 2002-08-28
RU2203902C2 (ru) 2003-05-10
HUP0002789A2 (hu) 2000-12-28
EP0994898A1 (de) 2000-04-26
CA2295219C (en) 2007-01-02
DE69812630D1 (de) 2003-04-30
JP2001509515A (ja) 2001-07-24
AU748134B2 (en) 2002-05-30
CN1262688A (zh) 2000-08-09
NO20000126D0 (no) 2000-01-10
AU8341398A (en) 1999-02-08
HU225326B1 (en) 2006-09-28
US6096707A (en) 2000-08-01
NO20000126L (no) 2000-01-10

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