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ATE262537T1 - Proliferationsinhibitor von endothellzellen und dessen verwendung - Google Patents

Proliferationsinhibitor von endothellzellen und dessen verwendung

Info

Publication number
ATE262537T1
ATE262537T1 AT96945635T AT96945635T ATE262537T1 AT E262537 T1 ATE262537 T1 AT E262537T1 AT 96945635 T AT96945635 T AT 96945635T AT 96945635 T AT96945635 T AT 96945635T AT E262537 T1 ATE262537 T1 AT E262537T1
Authority
AT
Austria
Prior art keywords
cell proliferation
endothelar
proliferation inhibitor
inhibitor
endothelial cell
Prior art date
Application number
AT96945635T
Other languages
English (en)
Inventor
Yihai Cao
Moses Judah Folkman
Michael S O'reilly
Donald J Davidson
Original Assignee
Childrens Medical Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/763,528 external-priority patent/US5854221A/en
Application filed by Childrens Medical Center filed Critical Childrens Medical Center
Application granted granted Critical
Publication of ATE262537T1 publication Critical patent/ATE262537T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6435—Plasmin (3.4.21.7), i.e. fibrinolysin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21007—Plasmin (3.4.21.7), i.e. fibrinolysin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • Toxicology (AREA)
  • Oncology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Farming Of Fish And Shellfish (AREA)
  • Medicines Containing Plant Substances (AREA)
AT96945635T 1995-12-13 1996-12-13 Proliferationsinhibitor von endothellzellen und dessen verwendung ATE262537T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US851995P 1995-12-13 1995-12-13
US08/763,528 US5854221A (en) 1996-12-12 1996-12-12 Endothelial cell proliferation inhibitor and method of use
PCT/US1996/020447 WO1997023500A1 (en) 1995-12-13 1996-12-13 Endothelial cell proliferation inhibitor and method of use

Publications (1)

Publication Number Publication Date
ATE262537T1 true ATE262537T1 (de) 2004-04-15

Family

ID=26678280

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96945635T ATE262537T1 (de) 1995-12-13 1996-12-13 Proliferationsinhibitor von endothellzellen und dessen verwendung

Country Status (20)

Country Link
US (1) US20010016644A1 (de)
EP (1) EP0869970B1 (de)
JP (1) JP3684371B2 (de)
KR (1) KR100477280B1 (de)
CN (1) CN1554444A (de)
AT (1) ATE262537T1 (de)
AU (1) AU710612B2 (de)
BR (1) BR9612115A (de)
CA (1) CA2240296C (de)
CZ (1) CZ298612B6 (de)
DE (1) DE69631972T2 (de)
DK (1) DK0869970T3 (de)
ES (1) ES2217340T3 (de)
HK (1) HK1017692A1 (de)
HU (1) HUP9900979A3 (de)
NO (1) NO321775B1 (de)
NZ (1) NZ330537A (de)
PL (1) PL188719B1 (de)
PT (1) PT869970E (de)
WO (1) WO1997023500A1 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP9900979A3 (en) * 1995-12-13 2001-10-29 Children S Medical Ct Corp Bos Endothelial cell proliferation inhibitor and method of use
US6699838B1 (en) 1996-05-03 2004-03-02 Abbott Laboratories Antiangiogenic peptides
US5801146A (en) * 1996-05-03 1998-09-01 Abbott Laboratories Compound and method for inhibiting angiogenesis
IL126626A0 (en) * 1996-05-03 1999-08-17 Abbott Lab Novel antiangiogenic peptides polynucleotides encoding same and methods for inhibiting angiogenesis
US5801012A (en) 1996-09-17 1998-09-01 Northwestern University Methods and compositions for generating angiostatin
EP1001985A1 (de) * 1997-06-26 2000-05-24 Karolinska Innovations AB Kringle-domänen 1-5 von plasminogen, fähig zur beeinflussung der angiogenese
WO1999026480A1 (en) * 1997-11-20 1999-06-03 Genetix Pharmaceuticals, Inc. Anti-angiogenic gene therapy vectors and their use in treating angiogenesis-related diseases
US6632961B1 (en) 1998-05-22 2003-10-14 Abbott Laboratories Antiangiogenic drug to treat cancer, arthritis and retinopathy
CA2363712C (en) 1999-05-17 2011-05-10 Conjuchem Inc. Long lasting insulinotropic peptides
US7144854B1 (en) 1999-09-10 2006-12-05 Conjuchem, Inc. Long lasting anti-angiogenic peptides
CA2373252C (en) * 1999-05-17 2007-08-07 Conjuchem Inc. Long lasting anti-angiogenic peptides
WO2001044294A2 (en) * 1999-12-15 2001-06-21 Entremed, Inc. Compositions and methods for inhibiting endothelial cell proliferation
AU8591901A (en) 2000-09-05 2002-03-22 Karolinska Innovations Ab Materials and methods relating to endothelial cell growth inhibitors
WO2002040510A2 (en) * 2000-11-02 2002-05-23 Bristol-Myers Squibb Company Modified plasminogen related peptide fragments and their use as angiogenesis inhibitors
WO2005072341A2 (en) * 2004-01-21 2005-08-11 Fujirebio America, Inc. Detection of mesothelin-/megakaryocyte potentiating factor-related peptides in peritoneal fluid for assessment of the peritoneum and the peritoneal cavity
CN100355458C (zh) * 2005-03-16 2007-12-19 北京大学 人增殖抑制基因－腺病毒表达载体的应用
EP2435562A1 (de) 2009-05-26 2012-04-04 Biolex Therapeutics, Inc. Zusammensetzungen und verfahren zur herstellung von aglycosyliertem plasminogen
CN103060265B (zh) * 2013-01-23 2014-12-03 山东大学 老年大鼠脑血管内皮细胞原代培养方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4929444A (en) * 1985-05-28 1990-05-29 Burroughs Wellcome Co. Low pH pharmaceutical formulation containing t-PA
US5149533A (en) * 1987-06-04 1992-09-22 Zymogenetics, Inc. Modified t-PA with kringle-/replaced by another kringle
US5302390A (en) * 1987-07-01 1994-04-12 Beecham Group Plc Hybrid proteins of human plasminogen and human t-PA, pharmaceutical compositions and methods of treatment
EP0589181A3 (de) * 1992-07-30 1995-02-22 Yeda Res & Dev Synthetische Vitronectin Derivate und deren pharmazeutische Zusammensetzungen.
AU2355895A (en) * 1994-04-26 1995-11-16 Pharmacia & Upjohn Company Mac-1 i-domain protein useful in blocking adhesion and migration of neutrophils
US5885795A (en) * 1994-04-26 1999-03-23 The Children's Medical Center Corporation Methods of expressing angiostatic protein
ATE368051T1 (de) * 1995-04-26 2007-08-15 Childrens Medical Center Angiostatinfragmente und verfahren für deren verwendung
HUP9900979A3 (en) * 1995-12-13 2001-10-29 Children S Medical Ct Corp Bos Endothelial cell proliferation inhibitor and method of use

Also Published As

Publication number Publication date
CZ298612B6 (cs) 2007-11-21
EP0869970A4 (de) 2002-01-30
NZ330537A (en) 2001-06-29
NO321775B1 (no) 2006-07-03
AU710612B2 (en) 1999-09-23
US20010016644A1 (en) 2001-08-23
CZ182898A3 (cs) 1998-10-14
DE69631972D1 (de) 2004-04-29
JP3684371B2 (ja) 2005-08-17
HK1017692A1 (en) 1999-11-26
HUP9900979A3 (en) 2001-10-29
KR100477280B1 (ko) 2005-07-18
DE69631972T2 (de) 2005-01-05
CA2240296C (en) 2004-05-04
NO982715D0 (no) 1998-06-12
EP0869970A1 (de) 1998-10-14
CN1554444A (zh) 2004-12-15
HUP9900979A2 (hu) 1999-07-28
EP0869970B1 (de) 2004-03-24
ES2217340T3 (es) 2004-11-01
PT869970E (pt) 2004-08-31
WO1997023500A1 (en) 1997-07-03
PL327200A1 (en) 1998-11-23
PL188719B1 (pl) 2005-04-29
CA2240296A1 (en) 1997-07-03
DK0869970T3 (da) 2004-07-05
NO982715L (no) 1998-08-12
KR19990072126A (ko) 1999-09-27
JP2002502359A (ja) 2002-01-22
AU1687097A (en) 1997-07-17
BR9612115A (pt) 1999-02-17

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