Nothing Special   »   [go: up one dir, main page]

ATE224372T1 - Substituierte 6-alkylphenanthridine - Google Patents

Substituierte 6-alkylphenanthridine

Info

Publication number
ATE224372T1
ATE224372T1 AT98942571T AT98942571T ATE224372T1 AT E224372 T1 ATE224372 T1 AT E224372T1 AT 98942571 T AT98942571 T AT 98942571T AT 98942571 T AT98942571 T AT 98942571T AT E224372 T1 ATE224372 T1 AT E224372T1
Authority
AT
Austria
Prior art keywords
alkylphenanthridine
substituted
ipharmaceutically
compositions
compounds
Prior art date
Application number
AT98942571T
Other languages
English (en)
Inventor
Hermann Amschler
Dieter Flockerzi
Wolf-Ruediger Ulrich
Thomas Baer
Thomas Martin
Christian Schudt
Armin Hatzelmann
Rolf Beume
Dietrich Haefner
Hildegard Boss
Hans-Peter Kley
Beate Gutterer
Original Assignee
Altana Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Altana Pharma Ag filed Critical Altana Pharma Ag
Application granted granted Critical
Publication of ATE224372T1 publication Critical patent/ATE224372T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/02Nasal agents, e.g. decongestants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/10Anti-acne agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/14Drugs for dermatological disorders for baldness or alopecia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D221/00Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04Ortho- or peri-condensed ring systems
    • C07D221/06Ring systems of three rings
    • C07D221/10Aza-phenanthrenes
    • C07D221/12Phenanthridines

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT98942571T 1997-07-25 1998-07-18 Substituierte 6-alkylphenanthridine ATE224372T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP97112794 1997-07-25
PCT/EP1998/004476 WO1999005112A1 (en) 1997-07-25 1998-07-18 Substituted 6-alkylphenanthridines

Publications (1)

Publication Number Publication Date
ATE224372T1 true ATE224372T1 (de) 2002-10-15

Family

ID=8227118

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98942571T ATE224372T1 (de) 1997-07-25 1998-07-18 Substituierte 6-alkylphenanthridine

Country Status (11)

Country Link
US (1) US6214839B1 (de)
EP (1) EP1000034B1 (de)
JP (1) JP2001510826A (de)
AT (1) ATE224372T1 (de)
AU (1) AU9066498A (de)
DE (1) DE69808099T2 (de)
DK (1) DK1000034T3 (de)
ES (1) ES2184318T3 (de)
PT (1) PT1000034E (de)
SI (1) SI1000034T1 (de)
WO (1) WO1999005112A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA02001830A (es) 1999-08-21 2002-08-12 Byk Gulden Lomberg Chem Fab Combinacion sinergica de inhibidores de pde y agonista de beta 2 adrenoceptor.
WO2002005616A1 (en) * 2000-07-14 2002-01-24 Altana Pharma Ag Novel 6-phenylphenanthridines
CA2415935A1 (en) 2000-07-14 2002-01-24 Altana Pharma Ag Novel 6-heteroarylphenanthridines
EP1539164B1 (de) 2002-08-29 2006-12-20 ALTANA Pharma AG 2-hydroxy-6-phenylphenanthridine als pde-4-hemmer
US7423046B2 (en) 2002-08-29 2008-09-09 Nycomed Gmbh 3-hydroxy-6-phenylphenanthridines as pde-4 inhibitors
EP1720835B1 (de) 2004-02-18 2012-12-12 Nycomed GmbH Neue guanidinylsubstituierte hydroxy-6-phenylphenanthridine als wirksame phosphodiesterase-(pde-)4-inhibitoren
AR049419A1 (es) * 2004-03-03 2006-08-02 Altana Pharma Ag Hidroxi-6-fenilfenantridinas sustituidas con heterociclilo
US8003798B2 (en) 2004-03-03 2011-08-23 Nycomed Gmbh Hydroxy-6-heteroarylphenanthridines and their use as PDE4 inhibitors
MXPA06009892A (es) * 2004-03-10 2007-03-01 Altana Pharma Ag Nuevas hidroxi-6-fenilfenantridinas sustituidas con amido y su uso como inhibidores de la fosfodiesterasa tipo 4 (pde4).
WO2006026725A2 (en) 2004-08-31 2006-03-09 C.R. Bard, Inc. Self-sealing ptfe graft with kink resistance
BRPI0607645A2 (pt) 2005-03-02 2009-09-22 Nycomed Gmbh sais de derivados de hexaidrofenantridina substituìdos com 6-heterociclila
EP1887968A4 (de) * 2005-06-08 2013-01-23 Bard Inc C R Transplantate und stents mit anorganischem biokompatiblem calciumsalz
PT1890641T (pt) 2005-06-17 2017-05-30 Bard Inc C R Enxerto vascular com resistência à dobragem após o seu aperto
EP1945138A4 (de) 2005-11-09 2010-02-10 Bard Inc C R Implantate und stentprothesen
US9198749B2 (en) 2006-10-12 2015-12-01 C. R. Bard, Inc. Vascular grafts with multiple channels and methods for making

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1199773B (de) * 1962-02-23 1965-09-02 Hoffmann La Roche Verfahren zur Herstellung von 6-Methyl-8, 9-methylendioxy-1, 2, 3, 4, 4a, 5, 6, 10b-octahydrophenanthridin und dessen Salzen
US3243438A (en) 1962-02-23 1966-03-29 Hoffmann La Roche Octahydro phenanthridine compounds
US4309545A (en) * 1980-07-28 1982-01-05 Pfizer Inc. Oximino-1-hydroxyoctahydrobenzo[c]quinolines and derivatives thereof

Also Published As

Publication number Publication date
WO1999005112A1 (en) 1999-02-04
JP2001510826A (ja) 2001-08-07
PT1000034E (pt) 2003-02-28
EP1000034B1 (de) 2002-09-18
EP1000034A1 (de) 2000-05-17
DE69808099D1 (de) 2002-10-24
US6214839B1 (en) 2001-04-10
DK1000034T3 (da) 2003-01-27
SI1000034T1 (en) 2003-04-30
DE69808099T2 (de) 2003-05-15
ES2184318T3 (es) 2003-04-01
AU9066498A (en) 1999-02-16

Similar Documents

Publication Publication Date Title
TR200000059T2 (tr) Piridin türevleri
TR199900874T2 (xx) Heteroaril s�ksinamidler ve metalloproteinaz inhibit�r� olarak kullan�mlar�.
EA199900591A1 (ru) АЗОТСОДЕРЖАЩИЕ ГЕТЕРОАРОМАТИЧЕСКИЕ СОЕДИНЕНИЯ В КАЧЕСТВЕ ИНГИБИТОРОВ ФАКТОРА Ха
HUP9904361A2 (hu) Izobutil-gaba és származékai alkalmazása fájdalom kezelésére
DE69720773D1 (de) SAUERSTOFF ODER SCHWEFEL ENTHALTENDE 5-GLIEDRIGE HETEROAROMATISHE DERIVATIVE ALS FACTOR Xa HEMMER
DK1000034T3 (da) Substituerede 6-alkylphenanthridiner
ME00768B (me) Derivati supstituisanih benzol sulfonamida kao pro-lekovi cox-2 inhibitora
YU35697A (en) Substituted 6,6-hetero-bicyclic derivatives
IS6309A (is) Kínasólínafleiður
DE69831937D1 (de) Bicyclische protein-farnesyl-transferase inhibitoren
DE69728544D1 (de) Totalsynthese von acylfulvenen mit antitumorwirkung
ATE242206T1 (de) Substituierte derivate von benzosulphonamiden als hemmer des enzym cyclooxygenase ii
DE69833797D1 (de) Substituierte 2-benzylamino-2-phenyl-acetamidverbindungen
NO970340D0 (no) Organiske forbindelser
ATE374189T1 (de) Phthalazinon-derivate als pde 4 hemmer
TR199900153T2 (xx) H�cre �o�almas�n� �nlemek i�in ikame edilmi� bisindolilmaleimitler.
ES2088903T3 (es) Nuevos inhibidores de la s-adenosilmetionina descarboxilasa.
KR970706280A (ko) 5-HT1A 길항제로서의 비사이클릭 카복스아미드(Bicyclic carboxamides as 5-HT1 antagonists)
ID26809A (id) Senyawa-senyawa turunan sianoiminokuinoksalin
PT1049670E (pt) Derivados de azetidinocarboxamida para o tratamento de perturbacoes do snc
ES2173634T3 (es) Compuestos heterociclicos que presentan actividad inhibidora de mmp y tnf.
ES2185154T3 (es) Metodo de uso de inhibidores de la ciclooxigenasa-2 en el tratamiento y prevencion de la demencia.
FR2684992B1 (fr) Procede de preparation d'amino-2 nitro-7 benzothiazoles.
MX9700125A (es) Compuestos de pirimidina.
ATE293605T1 (de) Fluorierte 3,4-dihydrochinolin-derivative als nos-inhibitoren

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee