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ATE292180T1 - Fibrinolytisch wirksames polypeptid - Google Patents

Fibrinolytisch wirksames polypeptid

Info

Publication number
ATE292180T1
ATE292180T1 AT00965554T AT00965554T ATE292180T1 AT E292180 T1 ATE292180 T1 AT E292180T1 AT 00965554 T AT00965554 T AT 00965554T AT 00965554 T AT00965554 T AT 00965554T AT E292180 T1 ATE292180 T1 AT E292180T1
Authority
AT
Austria
Prior art keywords
polypeptide
fibrinolytic
vivo
useful
called
Prior art date
Application number
AT00965554T
Other languages
English (en)
Inventor
Thomas Charles Boone
Huimin Li
Michael Benjamin Mann
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Application granted granted Critical
Publication of ATE292180T1 publication Critical patent/ATE292180T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6489—Metalloendopeptidases (3.4.24)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6402—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from non-mammals
    • C12N9/6418—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from non-mammals from snakes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AT00965554T 1999-10-01 2000-09-29 Fibrinolytisch wirksames polypeptid ATE292180T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/411,329 US6261820B1 (en) 1999-10-01 1999-10-01 Fibronolytically active polypeptide
PCT/US2000/027029 WO2001025445A1 (en) 1999-10-01 2000-09-29 Fibrinolytically active polypeptide

Publications (1)

Publication Number Publication Date
ATE292180T1 true ATE292180T1 (de) 2005-04-15

Family

ID=23628486

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00965554T ATE292180T1 (de) 1999-10-01 2000-09-29 Fibrinolytisch wirksames polypeptid

Country Status (29)

Country Link
US (4) US6261820B1 (de)
EP (2) EP1224298B1 (de)
JP (1) JP2003511034A (de)
KR (2) KR100700753B1 (de)
CN (2) CN101230340A (de)
AT (1) ATE292180T1 (de)
AU (1) AU767827B2 (de)
BG (1) BG106577A (de)
BR (1) BR0014414A (de)
CA (1) CA2386185A1 (de)
CZ (1) CZ298502B6 (de)
DE (1) DE60019147T2 (de)
DK (1) DK1224298T3 (de)
EA (2) EA006487B1 (de)
ES (1) ES2240167T3 (de)
HK (1) HK1049351B (de)
HU (1) HUP0202650A3 (de)
IL (1) IL148787A0 (de)
MX (1) MXPA02003126A (de)
NO (1) NO20021501L (de)
NZ (1) NZ517951A (de)
PL (1) PL355017A1 (de)
PT (1) PT1224298E (de)
RS (1) RS20060033A (de)
SG (1) SG127720A1 (de)
SK (1) SK4232002A3 (de)
WO (1) WO2001025445A1 (de)
YU (2) YU59604A (de)
ZA (1) ZA200202206B (de)

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US6261820B1 (en) 1999-10-01 2001-07-17 Amgen Inc. Fibronolytically active polypeptide
US6440414B1 (en) 1999-10-01 2002-08-27 Amgen Inc. Pharmaceutical compositions of fibrinolytic agent
US6455269B1 (en) 1999-12-17 2002-09-24 Amgen, Inc. Method for localized administration of fibrinolytic metalloproteinases
US7033776B2 (en) 1999-12-17 2006-04-25 Amgen Inc. Method for treatment of indwelling catheter occlusion using fibrinolytic metalloproteinases
US6523647B2 (en) * 2001-05-21 2003-02-25 Hydro Mobile Inc. Elevating platform assembly
CA2475761C (en) * 2002-02-11 2011-07-12 Gold-T Tech, Inc. An implantable device which provides high frequency ultrasound energy to provide acoustical streaming to prevent thrombus formation
US7016409B2 (en) * 2003-11-12 2006-03-21 Sony Corporation Apparatus and method for use in providing dynamic bit rate encoding
ES2239532B1 (es) * 2004-02-06 2006-11-01 Proyecto De Biomedicina Cima S.L. Metodo para evaluar el riesgo y la predisposicion a desarrollar una patologia relacionada con la presencia de autoanticuerpos frente a epcr.
US20070141625A1 (en) * 2005-02-03 2007-06-21 Santos Jose H Method for assessing risk of and predisposition to development of a pathology related to the presence of anti-epcr autoantibodies
WO2007092820A2 (en) 2006-02-03 2007-08-16 Lazarus Effect, Inc. Methods and devices for restoring blood flow within blocked vasculature
EP2403583B1 (de) 2009-03-06 2016-10-19 Lazarus Effect, Inc. Abfragesysteme
WO2011056872A2 (en) 2009-11-03 2011-05-12 Gen9, Inc. Methods and microfluidic devices for the manipulation of droplets in high fidelity polynucleotide assembly
WO2012129363A2 (en) 2011-03-24 2012-09-27 President And Fellows Of Harvard College Single cell nucleic acid detection and analysis
WO2016040476A1 (en) 2014-09-09 2016-03-17 The Broad Institute, Inc. A droplet-based method and apparatus for composite single-cell nucleic acid analysis
US10456560B2 (en) 2015-02-11 2019-10-29 Covidien Lp Expandable tip medical devices and methods
WO2016145409A1 (en) 2015-03-11 2016-09-15 The Broad Institute, Inc. Genotype and phenotype coupling
US11092607B2 (en) 2015-10-28 2021-08-17 The Board Institute, Inc. Multiplex analysis of single cell constituents
WO2017075297A1 (en) 2015-10-28 2017-05-04 The Broad Institute Inc. High-throughput dynamic reagent delivery system
EP3402902B1 (de) 2016-01-15 2021-10-27 Massachusetts Institute Of Technology Halbdurchlässige anordnungen zur analyse biologischer system und verfahren zur verwendung davon
US11072816B2 (en) 2017-05-03 2021-07-27 The Broad Institute, Inc. Single-cell proteomic assay using aptamers

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US4447236A (en) * 1982-02-05 1984-05-08 Cordis Corporation Infusion catheter system
DE3330699A1 (de) * 1983-08-25 1985-03-07 Boehringer Mannheim Gmbh, 6800 Mannheim Verfahren zur gleichzeitigen bestimmung von fibrinogen und fibrinogen-spaltprodukten im plasma
US4610879A (en) 1984-01-06 1986-09-09 University Of Southern California Fibrinolytic enzyme from snake vernom
CA1237482A (en) * 1984-03-09 1988-05-31 Frank B. Stiles Catheter for effecting removal of obstructions from a biological duct
US4755167A (en) * 1984-04-10 1988-07-05 Research Corporation In vivo method for distribution and stirring of therapeutic agents
US4885242A (en) * 1984-10-30 1989-12-05 Phillips Petroleum Company Genes from pichia histidine pathway and uses thereof
US4837148A (en) * 1984-10-30 1989-06-06 Phillips Petroleum Company Autonomous replication sequences for yeast strains of the genus pichia
US4855231A (en) * 1984-10-30 1989-08-08 Phillips Petroleum Company Regulatory region for heterologous gene expression in yeast
US4818700A (en) * 1985-10-25 1989-04-04 Phillips Petroleum Company Pichia pastoris argininosuccinate lyase gene and uses thereof
US4812405A (en) * 1986-02-18 1989-03-14 Phillips Petroleum Company Double auxotrophic mutants of Pichia pastoris and methods for preparation
US5000185A (en) * 1986-02-28 1991-03-19 Cardiovascular Imaging Systems, Inc. Method for intravascular two-dimensional ultrasonography and recanalization
ZA889415B (en) 1987-12-18 1989-09-27 Chiron Corp Compositions and method for recombinant production of crotalidus venum fibrolase
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US5222941A (en) * 1990-01-12 1993-06-29 Don Michael T Anthony Method of dissolving an obstruction in a vessel
DK0438200T3 (da) * 1990-01-16 2002-11-11 Ct Ingenieria Genetica Biotech Fremgangsmåde til ekspression af heterologe gener i gæren Pichia pastoris, ekspressionsvektorer og transformerede mikroorganismer
US5709676A (en) * 1990-02-14 1998-01-20 Alt; Eckhard Synergistic treatment of stenosed blood vessels using shock waves and dissolving medication
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US5167628A (en) * 1991-05-02 1992-12-01 Boyles Paul W Aortic balloon catheter assembly for indirect infusion of the coronary arteries
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US5370653A (en) * 1993-07-22 1994-12-06 Micro Therapeutics, Inc. Thrombectomy method and apparatus
ATE249234T1 (de) 1993-12-17 2003-09-15 Mochida Pharm Co Ltd Lösliches thrombomodulin enthaltende zubereitung
US5626564A (en) * 1995-03-31 1997-05-06 Creighton University Adjustable sideholes catheter
US5830468A (en) 1995-05-17 1998-11-03 The New York Blood Center, Inc. Fibrin(ogen) degradation by fibrinolytic matrix metalloproteinase
US6020181A (en) * 1995-05-17 2000-02-01 New York Blood, Inc. Inhibition of thrombus formation by medical related apparatus comprising treating with fibrinolytic matrix metalloproteinase
US5741779A (en) * 1996-05-10 1998-04-21 Xoma Corporation Antithrombotic materials and methods
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US5951981A (en) * 1996-12-02 1999-09-14 Diatide, Inc. Thrombolytic agents with antithrombotic activity
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US6440414B1 (en) 1999-10-01 2002-08-27 Amgen Inc. Pharmaceutical compositions of fibrinolytic agent
US6261820B1 (en) 1999-10-01 2001-07-17 Amgen Inc. Fibronolytically active polypeptide
US6455269B1 (en) * 1999-12-17 2002-09-24 Amgen, Inc. Method for localized administration of fibrinolytic metalloproteinases
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Also Published As

Publication number Publication date
ES2240167T3 (es) 2005-10-16
EP1605049A3 (de) 2006-12-13
MXPA02003126A (es) 2002-09-30
SG127720A1 (en) 2006-12-29
DE60019147D1 (en) 2005-05-04
WO2001025445A1 (en) 2001-04-12
HK1049351B (zh) 2005-07-29
EP1224298A1 (de) 2002-07-24
CN101230340A (zh) 2008-07-30
YU59604A (sh) 2005-11-28
NZ517951A (en) 2004-02-27
NO20021501L (no) 2002-05-31
DE60019147T2 (de) 2006-05-11
PT1224298E (pt) 2005-06-30
IL148787A0 (en) 2002-09-12
EP1224298B1 (de) 2005-03-30
US20020058322A1 (en) 2002-05-16
YU22502A (sh) 2005-07-19
US20080058256A1 (en) 2008-03-06
ZA200202206B (en) 2002-12-24
AU7625400A (en) 2001-05-10
US6617145B2 (en) 2003-09-09
JP2003511034A (ja) 2003-03-25
PL355017A1 (en) 2004-03-22
KR100700753B1 (ko) 2007-03-28
US7195903B2 (en) 2007-03-27
NO20021501D0 (no) 2002-03-26
DK1224298T3 (da) 2005-05-30
BG106577A (bg) 2003-04-30
US6261820B1 (en) 2001-07-17
CZ20021034A3 (cs) 2003-06-18
EA200400290A1 (ru) 2005-02-24
US20030186422A1 (en) 2003-10-02
CZ298502B6 (cs) 2007-10-24
KR100711312B1 (ko) 2007-04-27
EP1605049A2 (de) 2005-12-14
CA2386185A1 (en) 2001-04-12
HUP0202650A3 (en) 2005-01-28
KR20020047208A (ko) 2002-06-21
HUP0202650A2 (hu) 2002-12-28
AU767827B2 (en) 2003-11-27
SK4232002A3 (en) 2003-09-11
EA005944B1 (ru) 2005-08-25
RS20060033A (sr) 2006-12-15
KR20060114034A (ko) 2006-11-03
HK1049351A1 (en) 2003-05-09
CN100357430C (zh) 2007-12-26
BR0014414A (pt) 2002-06-11
CN1402788A (zh) 2003-03-12
EA006487B1 (ru) 2005-12-29
EA200200410A1 (ru) 2002-10-31

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