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ATE288922T1 - Bestimmte heteroaryl substituierte thiol inhibitoren von endothelin wechselnden enzymen - Google Patents

Bestimmte heteroaryl substituierte thiol inhibitoren von endothelin wechselnden enzymen

Info

Publication number
ATE288922T1
ATE288922T1 AT99923433T AT99923433T ATE288922T1 AT E288922 T1 ATE288922 T1 AT E288922T1 AT 99923433 T AT99923433 T AT 99923433T AT 99923433 T AT99923433 T AT 99923433T AT E288922 T1 ATE288922 T1 AT E288922T1
Authority
AT
Austria
Prior art keywords
endothelin
heteroaryl substituted
substituted thiol
certain heteroaryl
thiol inhibitors
Prior art date
Application number
AT99923433T
Other languages
English (en)
Inventor
Cynthia Anne Fink
Fariborz Firooznia
Original Assignee
Novartis Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Pharma Gmbh filed Critical Novartis Pharma Gmbh
Application granted granted Critical
Publication of ATE288922T1 publication Critical patent/ATE288922T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT99923433T 1998-04-23 1999-04-21 Bestimmte heteroaryl substituierte thiol inhibitoren von endothelin wechselnden enzymen ATE288922T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6497998A 1998-04-23 1998-04-23
PCT/EP1999/002694 WO1999055723A1 (en) 1998-04-23 1999-04-21 Certain heteroaryl substituted thiol inhibitors of endothelin-converting enzyme

Publications (1)

Publication Number Publication Date
ATE288922T1 true ATE288922T1 (de) 2005-02-15

Family

ID=22059547

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99923433T ATE288922T1 (de) 1998-04-23 1999-04-21 Bestimmte heteroaryl substituierte thiol inhibitoren von endothelin wechselnden enzymen

Country Status (11)

Country Link
EP (1) EP1080104B1 (de)
JP (1) JP3646062B2 (de)
AT (1) ATE288922T1 (de)
AU (1) AU750048B2 (de)
CA (1) CA2324251A1 (de)
DE (1) DE69923676T2 (de)
ES (1) ES2237917T3 (de)
IL (1) IL138688A0 (de)
PT (1) PT1080104E (de)
WO (1) WO1999055723A1 (de)
ZA (1) ZA200004679B (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6426354B1 (en) 1998-04-23 2002-07-30 Novartis Ag Certain heteroaryl substituted thiol inhibitors of endothelin-converting enzyme
US6423727B1 (en) 1998-04-23 2002-07-23 Novartis Ag Certain thiol inhibitors of endothelin-converting enzyme
JP4603646B2 (ja) * 1999-11-15 2010-12-22 富士フイルムファインケミカルズ株式会社 新規なジピリジル誘導体
NL1014353C2 (nl) * 2000-02-11 2001-08-15 Dsm Nv Werkwijze voor de bereiding van (R) -2-broom-3-fenylpropaanzuur.
US20020028799A1 (en) * 2000-07-06 2002-03-07 Naylor Alasdair Mark Treatment of male sexual dysfunction
US6670479B2 (en) * 2001-03-07 2003-12-30 Advanced Research And Technology Institute, Inc. Amination process
US6777443B2 (en) 2001-05-15 2004-08-17 Novartis Ag Dipeptide derivatives
WO2003027091A1 (en) 2001-09-21 2003-04-03 Novartis Ag Pyrane derivatives as both ace- and nep- inhibitors
JPWO2003066563A1 (ja) * 2002-02-04 2005-05-26 株式会社カネカ 光学活性２−ハロゲノカルボン酸の製造法
DE60303441T2 (de) 2002-02-08 2006-09-21 Merck & Co., Inc. N-biphenylmethylaminocycloalkancarboxamid-derivative
TWI259079B (en) 2002-02-08 2006-08-01 Merck & Co Inc N-biphenyl(substituted methyl)aminocycloalkanecarboxamide derivatives
JP3975226B2 (ja) 2006-01-11 2007-09-12 生化学工業株式会社 シクロアルキルカルボニルアミノ酸誘導体及びその製造方法
AU2007205578B2 (en) * 2006-01-11 2012-06-28 Seikagaku Corporation Cycloalkylcarbonylamino acid ester derivative and process for producing the same
JP4047365B2 (ja) 2006-01-11 2008-02-13 生化学工業株式会社 シクロアルカンカルボキサミド誘導体及びその製造方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5432186A (en) * 1993-11-16 1995-07-11 Ciba-Geigy Corporation Cyclic amino acid derivatives
FR2745571B1 (fr) * 1996-03-04 1998-06-19 Inst Nat Sante Rech Med Nouveaux derives soufres comportant une liaison amide, leur procede de preparation, leur application a titre de medicaments, et les compositions pharmaceutiques les renfermant
FR2745570B1 (fr) * 1996-03-04 1998-06-19 Roussel Uclaf Nouveaux derives soufres comportant une liaison retroamide, leur procede et intermediaires de preparation, leur application a titre de medicaments, et les compositions pharmaceutiques les renfermant

Also Published As

Publication number Publication date
DE69923676D1 (de) 2005-03-17
ES2237917T3 (es) 2005-08-01
AU4031999A (en) 1999-11-16
EP1080104A1 (de) 2001-03-07
DE69923676T2 (de) 2006-01-12
WO1999055723A1 (en) 1999-11-04
CA2324251A1 (en) 1999-11-04
JP2002513029A (ja) 2002-05-08
JP3646062B2 (ja) 2005-05-11
IL138688A0 (en) 2001-10-31
EP1080104B1 (de) 2005-02-09
AU750048B2 (en) 2002-07-11
PT1080104E (pt) 2005-06-30
ZA200004679B (en) 2002-04-24

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