AR084937A1 - Anticuerpos humanos frente a pcsk9 para uso en metodos de tratamiento basados en regimenes de dosificacion particulares - Google Patents
Anticuerpos humanos frente a pcsk9 para uso en metodos de tratamiento basados en regimenes de dosificacion particularesInfo
- Publication number
- AR084937A1 AR084937A1 ARP120100274A ARP120100274A AR084937A1 AR 084937 A1 AR084937 A1 AR 084937A1 AR P120100274 A ARP120100274 A AR P120100274A AR P120100274 A ARP120100274 A AR P120100274A AR 084937 A1 AR084937 A1 AR 084937A1
- Authority
- AR
- Argentina
- Prior art keywords
- antibody
- range
- binding fragment
- hmg
- coa reductase
- Prior art date
Links
- 101001098868 Homo sapiens Proprotein convertase subtilisin/kexin type 9 Proteins 0.000 title abstract 3
- 102100038955 Proprotein convertase subtilisin/kexin type 9 Human genes 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- 239000012634 fragment Substances 0.000 abstract 9
- 239000000427 antigen Substances 0.000 abstract 7
- 102000036639 antigens Human genes 0.000 abstract 7
- 108091007433 antigens Proteins 0.000 abstract 7
- 229940121710 HMGCoA reductase inhibitor Drugs 0.000 abstract 5
- 239000002471 hydroxymethylglutaryl coenzyme A reductase inhibitor Substances 0.000 abstract 5
- 101710172072 Kexin Proteins 0.000 abstract 3
- 108090000787 Subtilisin Proteins 0.000 abstract 3
- 201000010099 disease Diseases 0.000 abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 3
- 230000000694 effects Effects 0.000 abstract 3
- 230000001225 therapeutic effect Effects 0.000 abstract 3
- 108010044159 Proprotein Convertases Proteins 0.000 abstract 2
- 102000006437 Proprotein Convertases Human genes 0.000 abstract 2
- 239000005022 packaging material Substances 0.000 abstract 2
- 201000001320 Atherosclerosis Diseases 0.000 abstract 1
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 208000032928 Dyslipidaemia Diseases 0.000 abstract 1
- 208000035150 Hypercholesterolemia Diseases 0.000 abstract 1
- 208000031226 Hyperlipidaemia Diseases 0.000 abstract 1
- 208000017170 Lipid metabolism disease Diseases 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/92—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving lipids, e.g. cholesterol, lipoproteins, or their receptors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
- C07K14/4703—Inhibitors; Suppressors
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/04—Endocrine or metabolic disorders
- G01N2800/044—Hyperlipemia or hypolipemia, e.g. dyslipidaemia, obesity
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Diabetes (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Obesity (AREA)
- Mycology (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Emergency Medicine (AREA)
- Vascular Medicine (AREA)
- Biomedical Technology (AREA)
- General Physics & Mathematics (AREA)
- Gastroenterology & Hepatology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Cell Biology (AREA)
- Pathology (AREA)
Abstract
Reivindicación 1: Un método para tratar una enfermedad o afección en la que la expresión o actividad de PCSK9 causa un impacto, que comprende: administrar una cantidad terapéutica de un anticuerpo o un fragmento del mismo de unión a antígeno, que se une específicamente a hPCSK9 (proproteína convertasa subtilisina/kexina tipo 9 humana) a un individuo que lo necesita, en donde el anticuerpo o fragmento del mismo de unión a antígeno se administra en una cantidad de dosificación en el intervalo de 5 mg a 500 mg, y administrar una cantidad terapéutica de un inhibidor de HMG-CoA reductasa a dicho sujeto, donde el inhibidor de HMG-CoA reductasa se administra en una cantidad de dosificación en el intervalo de 0,05 mg a 100 mg.Reivindicación 2: Un anticuerpo o un fragmento del mismo que se une a antígeno, que se une específicamente a hPCSK9 (proproteína convertasa subtilisina/kexina tipo 9 humana) para uso en el tratamiento de una enfermedad o afección en la que la expresión o actividad de PCSK9 causa un impacto, en donde el anticuerpo o fragmento del mismo que se une a anticuerpo es para administración en una cantidad de dosificación en el intervalo de 5 mg a 500 mg, (i) en donde el anticuerpo o fragmento del mismo que se une a anticuerpo además es para administración en combinación con un inhibidor de HMG-CoA reductasa en una cantidad de dosificación en el intervalo de 0,05 mg a 100 mg. Reivindicación 23: Un artículo manufacturado que comprende (a) un material de envasado; (b) un anticuerpo o un fragmento de unión al antígeno del mismo que se unen específicamente a hPCSK9; y (c) una etiqueta o prospecto contenido en el material de envasado que indica que los pacientes que reciben tratamiento con dicho anticuerpo o fragmento de unión al antígeno se pueden tratar de una enfermedad o afección seleccionada del grupo que consiste en hipercolesterolemia, hiperlipidemia, dislipidemia, aterosclerosis y enfermedades cardiovasculares. Reivindicación 36: Un método para prevenir los efectos de un nivel de LDL (persistentemente) elevado en la sangre, que comprende: administrar una cantidad terapéutica de un anticuerpo o un fragmento del mismo de unión a antígeno, que se une específicamente a hPCSK9 (proproteína convertasa subtilisina/kexina tipo 9 humana) a un individuo que lo necesita, en donde el anticuerpo o fragmento del mismo de unión a antígeno se administra en una cantidad de dosificación en el intervalo de 5 mg a 500 mg, y administrar una cantidad terapéutica de un inhibidor de HMG-CoA reductasa a dicho sujeto, donde el inhibidor de HMG-CoA reductasa se administra en una cantidad de dosificación en el intervalo de 0,05 mg a 100 mg.
Applications Claiming Priority (10)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11305088.4A EP2650016A1 (en) | 2011-01-28 | 2011-01-28 | Human antibodies to PSCK9 for use in methods of treatment based on particular dosage regimens (11565) |
| EP11305089A EP2481758A1 (en) | 2011-01-28 | 2011-01-28 | Human antibodies to PSCK9 for use in methods of treating particular groups of subjects (11566) |
| EP11305513 | 2011-04-29 | ||
| EP11305514 | 2011-04-29 | ||
| EP11306039 | 2011-08-12 | ||
| EP11306040 | 2011-08-12 | ||
| EP11306202 | 2011-09-22 | ||
| EP11306201 | 2011-09-22 | ||
| EP11306450 | 2011-11-08 | ||
| EP11306449 | 2011-11-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR084937A1 true AR084937A1 (es) | 2013-07-10 |
Family
ID=45529125
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP120100275A AR084938A1 (es) | 2011-01-28 | 2012-01-27 | Anticuerpos humanos contra la proproteina convertasa subtilisina/kexina tipo 9 (anti pcsk9) para usar en metodos para tratar grupos de pacientes |
| ARP120100274A AR084937A1 (es) | 2011-01-28 | 2012-01-27 | Anticuerpos humanos frente a pcsk9 para uso en metodos de tratamiento basados en regimenes de dosificacion particulares |
| ARP120100276A AR084939A1 (es) | 2011-01-28 | 2012-01-27 | Composiciones farmaceuticas que comprenden anticuerpos humanos frente a pcsk9, formas de dosificacion unitarias, articulo manufacturado, metodo |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP120100275A AR084938A1 (es) | 2011-01-28 | 2012-01-27 | Anticuerpos humanos contra la proproteina convertasa subtilisina/kexina tipo 9 (anti pcsk9) para usar en metodos para tratar grupos de pacientes |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP120100276A AR084939A1 (es) | 2011-01-28 | 2012-01-27 | Composiciones farmaceuticas que comprenden anticuerpos humanos frente a pcsk9, formas de dosificacion unitarias, articulo manufacturado, metodo |
Country Status (39)
| Country | Link |
|---|---|
| US (6) | US9561155B2 (es) |
| EP (4) | EP3326648B1 (es) |
| JP (8) | JP6375113B2 (es) |
| KR (6) | KR20190090055A (es) |
| CN (4) | CN103476797A (es) |
| AR (3) | AR084938A1 (es) |
| AU (5) | AU2012210480B2 (es) |
| BR (2) | BR112013018740A2 (es) |
| CA (2) | CA2825778A1 (es) |
| CL (2) | CL2013002162A1 (es) |
| CO (2) | CO6751277A2 (es) |
| CR (1) | CR20130406A (es) |
| CY (1) | CY1121236T1 (es) |
| DK (1) | DK2668212T3 (es) |
| DO (1) | DOP2013000170A (es) |
| EC (1) | ECSP13012792A (es) |
| ES (3) | ES2674600T3 (es) |
| GT (1) | GT201300186A (es) |
| HK (1) | HK1255729A1 (es) |
| HR (1) | HRP20180959T1 (es) |
| HU (1) | HUE039258T2 (es) |
| IL (5) | IL227658A0 (es) |
| LT (1) | LT2668212T (es) |
| MA (1) | MA34923B1 (es) |
| MX (4) | MX347602B (es) |
| MY (2) | MY176600A (es) |
| NI (1) | NI201300064A (es) |
| NZ (1) | NZ792724A (es) |
| PE (2) | PE20181052A1 (es) |
| PH (1) | PH12021500018A1 (es) |
| PL (3) | PL3326648T3 (es) |
| PT (1) | PT2668212T (es) |
| RS (1) | RS57339B1 (es) |
| RU (4) | RU2721279C2 (es) |
| SG (2) | SG192117A1 (es) |
| SI (1) | SI2668212T1 (es) |
| TW (3) | TW201242613A (es) |
| WO (3) | WO2012101252A2 (es) |
| ZA (2) | ZA201305524B (es) |
Families Citing this family (141)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JOP20080381B1 (ar) | 2007-08-23 | 2023-03-28 | Amgen Inc | بروتينات مرتبطة بمولدات مضادات تتفاعل مع بروبروتين كونفيرتاز سيتيليزين ككسين من النوع 9 (pcsk9) |
| JO3672B1 (ar) | 2008-12-15 | 2020-08-27 | Regeneron Pharma | أجسام مضادة بشرية عالية التفاعل الكيماوي بالنسبة لإنزيم سبتيليسين كنفرتيز بروبروتين / كيكسين نوع 9 (pcsk9). |
| US20130064834A1 (en) | 2008-12-15 | 2013-03-14 | Regeneron Pharmaceuticals, Inc. | Methods for treating hypercholesterolemia using antibodies to pcsk9 |
| KR101709492B1 (ko) | 2009-03-18 | 2017-02-23 | 리스버로직스 코퍼레이션 | 신규한 소염제 |
| MY176600A (en) | 2011-01-28 | 2020-08-18 | Sanofi Biotechnology | Pharmaceutical compositions comprising human antibodies to pcsk9 |
| CA2840482C (en) * | 2011-07-14 | 2018-10-16 | Pfizer Inc. | Treatment with anti-pcsk9 antibodies |
| AR087305A1 (es) | 2011-07-28 | 2014-03-12 | Regeneron Pharma | Formulaciones estabilizadas que contienen anticuerpos anti-pcsk9, metodo de preparacion y kit |
| EA028278B1 (ru) | 2011-09-16 | 2017-10-31 | Ридженерон Фармасьютикалз, Инк. | СПОСОБЫ СНИЖЕНИЯ УРОВНЕЙ ЛИПОПРОТЕИНА(а) ПОСРЕДСТВОМ ВВЕДЕНИЯ ИНГИБИТОРА ПРОПРОТЕИНКОНВЕРТАЗЫ СУБТИЛИЗИН/КЕКСИН-9 (PCSK9) |
| US9255154B2 (en) | 2012-05-08 | 2016-02-09 | Alderbio Holdings, Llc | Anti-PCSK9 antibodies and use thereof |
| EP2861624A1 (en) | 2012-06-15 | 2015-04-22 | F. Hoffmann-La Roche AG | Anti-pcsk9 antibodies, formulations, dosing, and methods of use |
| CN104540852B (zh) * | 2012-08-13 | 2018-10-02 | 瑞泽恩制药公司 | 具有pH-依赖性结合特性的抗-PCSK9抗体 |
| EP2703008A1 (en) * | 2012-08-31 | 2014-03-05 | Sanofi | Human antibodies to PCSK9 for use in methods of treating particular groups of subjects |
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| KR20230007538A (ko) | 2014-07-16 | 2023-01-12 | 사노피 바이오테크놀로지 | 고콜레스테롤혈증이 있는 심혈관 위험이 높은 환자를 치료하는 방법 |
| KR20170029613A (ko) | 2014-07-16 | 2017-03-15 | 사노피 바이오테크놀로지 | 이형접합성 가족성 고콜레스테롤혈증(heFH) 환자의 치료방법 |
| EA201890519A1 (ru) | 2015-08-18 | 2018-07-31 | Ридженерон Фармасьютикалз, Инк. | Ингибирующие антитела против pcsk9 для лечения пациентов с гиперлипидемией, подвергающихся аферезу липопротеинов |
| US10933134B2 (en) | 2017-03-16 | 2021-03-02 | Memorial Sloan Kettering Cancer Center | Combination therapies for treatment of cancer |
| TW201904608A (zh) | 2017-06-09 | 2019-02-01 | 法商賽諾菲生物技術公司 | 藉由投予ｐｃｓｋ９抑制劑治療糖尿病患者高血脂症之方法 |
| US20190031774A1 (en) | 2017-06-09 | 2019-01-31 | Sanofi Biotechnology | Methods for treating hyperlipidemia in diabetic patients by administering a pcsk9 inhibitor |
| EP3762026A1 (en) | 2018-03-06 | 2021-01-13 | Sanofi Biotechnology | Use of pcsk9 inhibitor for reducing cardiovascular risk |
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